BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P06731 (702 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1E07-A nrPDB 1305 0.0 5OJ2-A nrPDB 75 7e-14 3JXA-A nrPDB 73 4e-13 5O5G-A nrPDB 68 2e-11 5Z5K-A nrPDB 65 1e-10 6IAA-A nrPDB 65 1e-10 6DLD-B nrPDB 63 4e-10 3V2A-R nrPDB 56 5e-08 2WIM-A nrPDB 55 7e-08 6DLF-A nrPDB 54 2e-07 3K0W-A nrPDB 52 8e-07 1QZ1-A nrPDB 48 2e-05 3V6B-R nrPDB 47 4e-05 4FOM-A nrPDB 45 8e-05 4MYW-B nrPDB 43 4e-04 3S97-C nrPDB 42 0.001 5VI4-B nrPDB 41 0.002 5OYJ-C nrPDB 40 0.003 3BFO-A nrPDB 40 0.004 5IMK-A nrPDB 39 0.010 2L7J-A nrPDB 39 0.010 3O3U-N nrPDB 38 0.014 2XY2-A nrPDB 38 0.019 4BSJ-A nrPDB 37 0.032 5B22-A nrPDB 36 0.060 3O2D-A nrPDB 35 0.12 1WIO-A nrPDB 35 0.12 3O4O-B nrPDB 35 0.13 4Q6I-C nrPDB 35 0.13 4BFI-B nrPDB 35 0.17 6FEY-A nrPDB 34 0.20 3MJ9-A nrPDB 33 0.60 4KC3-B nrPDB 32 0.66 1TLK-A nrPDB 32 1.3 1OLZ-A nrPDB 31 1.5 3NVQ-A nrPDB 31 1.7 4BFE-A nrPDB 31 1.8 5T89-X nrPDB 30 2.9 1KOA-A nrPDB 30 3.2 1EPF-A nrPDB 30 3.2 3EC1-A nrPDB 30 3.4 1VCA-A nrPDB 30 5.3 3QS9-E nrPDB 29 5.7 1FSK-B nrPDB 29 7.5 4PBV-A nrPDB 29 8.3 4PBW-B nrPDB 29 8.4 4DEP-B nrPDB 29 8.7 1QGC-4 nrPDB 29 8.8 1IAI-M nrPDB 28 9.1 6J8G-B nrPDB 28 9.5 >1E07-A nrPDB Length = 642 Score = 1305 bits (3377), Expect = 0.0, Method: Compositional matrix adjust. Identities = 641/642 (99%), Positives = 642/642 (100%) Query: 35 KLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPA 94 KLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPA Sbjct: 1 KLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPA 60 Query: 95 YSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNS 154 YSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNS Sbjct: 61 YSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNS 120 Query: 155 KPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYK 214 KPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYK Sbjct: 121 KPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYK 180 Query: 215 CETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN 274 CETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN Sbjct: 181 CETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN 240 Query: 275 GTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 GTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP Sbjct: 241 GTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP 300 Query: 335 VEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECG 394 VEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECG Sbjct: 301 VEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECG 360 Query: 395 IQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGN 454 IQN+LSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGN Sbjct: 361 IQNELSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGN 420 Query: 455 IQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVE 514 IQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVE Sbjct: 421 IQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVE 480 Query: 515 DKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQ 574 DKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQ Sbjct: 481 DKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQ 540 Query: 575 NSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQ 634 NSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQ Sbjct: 541 NSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQ 600 Query: 635 QHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSA 676 QHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSA Sbjct: 601 QHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSA 642 Score = 509 bits (1312), Expect = e-144, Method: Compositional matrix adjust. Identities = 265/402 (65%), Positives = 299/402 (74%), Gaps = 1/402 (0%) Query: 284 LFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVAL 343 L I NI N++G YT SD +N VY E PKP I+SNNS PVED+DAVA Sbjct: 73 LLIQNIIQNDTGFYTLHVIKSDL-VNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAF 131 Query: 344 TCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDH 403 TCEPE Q+ TYLWWVNNQSLPVSPRLQLSN NRTLTL +VTRND Y+C QN +S Sbjct: 132 TCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARR 191 Query: 404 SDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELF 463 SD VILNVLYGPD PTISP T YR G NL+LSCHAASNPPAQYSW ++G QQ TQELF Sbjct: 192 SDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELF 251 Query: 464 ISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTC 523 I NIT NSG YTCQA+NS +G +RTTV TITV AE PKP I+SNNS PVED+DAVA TC Sbjct: 252 IPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTC 311 Query: 524 EPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSD 583 EPE QNTTYLWWVN QSLPVSPRLQLSN NRTLTL +VTRND Y CGIQN +S + SD Sbjct: 312 EPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVDHSD 371 Query: 584 PVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIA 643 PV L+VLYGPD P ISP + Y G NL+LSCH+ASNP QYSW I+G QQHTQ LFI+ Sbjct: 372 PVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFIS 431 Query: 644 KITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSA 685 IT N+G Y C +N A+G + + VK+ITVSA P +S+ Sbjct: 432 NITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISS 473 >5OJ2-A nrPDB Length = 910 Score = 75.5 bits (184), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 124/539 (23%), Positives = 208/539 (38%), Gaps = 91/539 (16%) Query: 197 NRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAP------TISPLNTSYR 250 N TL + + R Y C+ +N V S+ ++V Y D P TIS + S+ Sbjct: 72 NETLRIEKIQRLQGGRYYCKAENGVGVPAIKSIRVDVQY-LDEPVLTVHQTISDVRGSFY 130 Query: 251 SGENLNLSCHAASNPPAQYSWFV----------NGT-------FQQSTQELFIPNITVNN 293 + + L C SNPPA++ W NG Q T+ L + N+ + Sbjct: 131 QEKTVFLRCTVNSNPPARFIWKRGAETLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQD 190 Query: 294 SGSYTCQ--AHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTC------ 345 SYTCQ N + +++ +T PP ++ N + V D V + C Sbjct: 191 YASYTCQVSVRNVCSIPDKSITFQLTNTTAPPALKLSVNETLVVNPGDNVTMQCSLTGGD 250 Query: 346 -EPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQN------K 398 +PE+ LW + LP + +Q N LT+ + D G Y C N K Sbjct: 251 PQPEV-----LWSHSPGPLPPNSLVQGGN----LTIWRIRVEDSGYYNCTAINNVGNPAK 301 Query: 399 LSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQ--YSWLIDGNIQ 456 +V+ + N + I S T + G +L LSCH + P + YSW +G Sbjct: 302 KTVNLLVRSMKNATFQITPDVIKESET-IQLGQDLKLSCHVDAVPQEKVVYSWYKNGKPA 360 Query: 457 QHTQELFIS----------------NITEKNSGLYTCQANNSASGHSRTTVKTITVSAEL 500 + + L I+ ++ + G Y C A + +V+ + +S+E Sbjct: 361 RFSDRLLITRNDPELPPVTCSLEIIDLRFSDYGTYLCVATFQGAPIPDLSVE-VNISSET 419 Query: 501 PKPSIS---SNNSKPVEDKDAVAFTCEPEAQNTTYLWW--VNGQSLPVSPRLQLSNGNRT 555 P+IS ++ V + CE + + W V+ ++ S + + + Sbjct: 420 VPPTISVPKGQSTITVREGSRAELQCEVRGKPKPPIIWSRVDKETPMPSGTMTVETYDGK 479 Query: 556 LTLFNVTRNDARAYVCGIQNSVSAN---RSDPVTLDVLYGPDTPIISPP--DSSYLSGAN 610 L L +V+R+ + Y C N R V L+V + P++ P D G + Sbjct: 480 LRLESVSRDMSGTYKCQTARYNGFNIRPREALVQLNVQF---PPVVEPAFQDVRQGMGRS 536 Query: 611 LNLSCHSASNPSPQYS---WRINGI-------PQQHTQVLFIAKITPNNNGTYACFVSN 659 + L C + + WR NG QQ L + ++ +G+Y C +SN Sbjct: 537 VTLRCTMLKGSPMKVATSVWRFNGTLLAQPPAEQQDYSELKVDSVSRETSGSYECSISN 595 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 93/410 (22%), Positives = 155/410 (37%), Gaps = 77/410 (18%) Query: 19 LLTASL--LTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGN 76 LL S+ TF P K ES + + ++ V +PQ YSWYK + Sbjct: 306 LLVRSMKNATFQITPDVIK---ESETIQLGQDLKLSCHVDAVPQEKVVYSWYKNGK---- 358 Query: 77 RQIIGYVIGTQQATPGPA-YSGREIIYPN--------ASLLIQNIIQNDTGFYTLHVIKS 127 PA +S R +I N SL I ++ +D G Y Sbjct: 359 ----------------PARFSDRLLITRNDPELPPVTCSLEIIDLRFSDYGTYLCVATFQ 402 Query: 128 DLVNEEATGQFRVYPELPKPSIS---SNNSKPVEDKDAVAFTCEPETQDATYLWW--VNN 182 + + + + E P+IS ++ V + CE + + W V+ Sbjct: 403 GAPIPDLSVEVNISSETVPPTISVPKGQSTITVREGSRAELQCEVRGKPKPPIIWSRVDK 462 Query: 183 QSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ--NPVSARRSDSVI-LNVLYGPDA 239 ++ S + + + L L +V+R+ + +YKC+T N + R ++++ LNV + Sbjct: 463 ETPMPSGTMTVETYDGKLRLESVSRDMSGTYKCQTARYNGFNIRPREALVQLNVQF---P 519 Query: 240 PTISPLNTSYRS--GENLNLSCHAASNPPAQYS---WFVNGTF-------QQSTQELFIP 287 P + P R G ++ L C P + + W NGT QQ EL + Sbjct: 520 PVVEPAFQDVRQGMGRSVTLRCTMLKGSPMKVATSVWRFNGTLLAQPPAEQQDYSELKVD 579 Query: 288 NITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEP 347 +++ SGSY C N D G+ + V A+ P + NP + Sbjct: 580 SVSRETSGSYECSISN-DVGV---SACLFQVSAKAYSPEFYYDTPNPT--------LSQK 627 Query: 348 EIQNTTY-LWWVNNQSLPVSPRL-------QLSNDNRTLTLLSVTRNDVG 389 + +N +Y L W + V P L QL+ N T + V + + G Sbjct: 628 QSKNYSYILQWTQKEPDAVDPILKYRLEVRQLAQRNTIQTFIPVQKMEKG 677 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 82/375 (21%), Positives = 132/375 (35%), Gaps = 67/375 (17%) Query: 105 ASLLIQNIIQNDTGFYTLHVIKSD----------LVNEEATGQFRVYPELPKPSISSNNS 154 +L I I D+G+Y I + LV F++ P++ K S Sbjct: 273 GNLTIWRIRVEDSGYYNCTAINNVGNPAKKTVNLLVRSMKNATFQITPDVIK------ES 326 Query: 155 KPVEDKDAVAFTCEPET---QDATYLWWVNNQSLPVSPRLQLSNGNR-------TLTLFN 204 + ++ + +C + + Y W+ N + S RL ++ + +L + + Sbjct: 327 ETIQLGQDLKLSCHVDAVPQEKVVYSWYKNGKPARFSDRLLITRNDPELPPVTCSLEIID 386 Query: 205 VTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS-PLNTS---YRSGENLNLSCH 260 + +D +Y C + SV +N+ PTIS P S R G L C Sbjct: 387 LRFSDYGTYLCVATFQGAPIPDLSVEVNISSETVPPTISVPKGQSTITVREGSRAELQCE 446 Query: 261 AASNPPAQYSW--------FVNGTFQQSTQE--LFIPNITVNNSGSYTCQAHNSDTGLN- 309 P W +GT T + L + +++ + SG+Y CQ + G N Sbjct: 447 VRGKPKPPIIWSRVDKETPMPSGTMTVETYDGKLRLESVSRDMSGTYKCQTARYN-GFNI 505 Query: 310 --RTTVTTITV----YAEPPKPFITSNNSNPVEDEDAVALTCE----PEIQNTTYLWWVN 359 R + + V EP + +V L C ++ T +W N Sbjct: 506 RPREALVQLNVQFPPVVEPAFQDVRQGMGR------SVTLRCTMLKGSPMKVATSVWRFN 559 Query: 360 NQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPT 419 L P Q D L + SV+R G YEC I N + V L+ Sbjct: 560 GTLLAQPPAEQ--QDYSELKVDSVSRETSGSYECSISNDVGVSA-------CLFQVSAKA 610 Query: 420 ISPSYTYYRPGVNLS 434 SP + Y P LS Sbjct: 611 YSPEFYYDTPNPTLS 625 >3JXA-A nrPDB Length = 383 Score = 73.2 bits (178), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 93/357 (26%), Positives = 142/357 (39%), Gaps = 44/357 (12%) Query: 253 ENLNLSCHAASNPPAQYSWFVNGT-------FQQSTQE--LFI--PNITVNNSGSYTCQA 301 + + LSC NP W +NGT F+ S + L I PN T ++G+Y C A Sbjct: 23 KKVKLSCEVKGNPKPHIRWKLNGTDVDIGMDFRYSVVDGSLLINNPNKT-QDAGTYQCIA 81 Query: 302 HNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCE--PEIQNTTYLWWVN 359 NS + Y E K S S V + L C P +Y W N Sbjct: 82 TNSFGTIVSREAKLQFAYLENFKTRTRSTVS--VRRGQGMVLLCGPPPHSGELSYAWIFN 139 Query: 360 NQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHS-----DPVIL--NVL 412 R +S + L + V ++DVG Y C + N ++ +H P+IL + + Sbjct: 140 EYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVT-NHKVLGPPTPLILRNDGV 198 Query: 413 YGPDDPTISPSYTYYRP---GVNLSLSCHAASNPPAQYSWL------IDGNIQQHTQE-- 461 G +P I + P G + L C A NP W I ++H Sbjct: 199 MGEYEPKIEVQFPETVPAEKGTTVKLECFALGNPVPTILWRRADGKPIARKARRHKSNGI 258 Query: 462 LFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPS-ISSNNSKPVEDKDAVA 520 L I N ++++G Y C A NS +T A+ P+ + N V +++V Sbjct: 259 LEIPNFQQEDAGSYECVAENSRG--KNVAKGQLTFYAQ---PNWVQIINDIHVAMEESVF 313 Query: 521 FTCEPEAQ-NTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNS 576 + C+ + TY W NG L R+Q+ G +T+ N++ DA Y C +N Sbjct: 314 WECKANGRPKPTYRWLKNGDPLLTRDRIQIEQGTLNITIVNLS--DAGMYQCVAENK 368 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 77/354 (21%), Positives = 128/354 (36%), Gaps = 38/354 (10%) Query: 337 DEDAVALTCEPEIQNTTYLWW-VNNQSLPVSPRLQLSNDNRTLTLLSVTR-NDVGPYECG 394 +E V L+CE + ++ W +N + + + S + +L + + + D G Y+C Sbjct: 21 EEKKVKLSCEVKGNPKPHIRWKLNGTDVDIGMDFRYSVVDGSLLINNPNKTQDAGTYQCI 80 Query: 395 IQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQ-----YSW 449 N S L Y + T + S R G + L C PP Y+W Sbjct: 81 ATNSFGTIVSREAKLQFAYLENFKTRTRSTVSVRRGQGMVLLC----GPPPHSGELSYAW 136 Query: 450 LIDGN---------IQQHTQELFISNITEKNSGLYTCQANNSASGHSRT------TVKTI 494 + + + Q T L+I+ + + + G YTC N+ + H ++ Sbjct: 137 IFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRND 196 Query: 495 TVSAEL-PKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGN 553 V E PK + + P E V C + W P++ + + N Sbjct: 197 GVMGEYEPKIEVQFPETVPAEKGTTVKLECFALGNPVPTILWRRADGKPIARKARRHKSN 256 Query: 554 RTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPD-TPIISPPDSSYLSGANLN 612 L + N + DA +Y C +NS N + L P+ II+ D ++ Sbjct: 257 GILEIPNFQQEDAGSYECVAENSRGKNVAKG-QLTFYAQPNWVQIIN--DIHVAMEESVF 313 Query: 613 LSCHSASNPSPQYSWRINGIP-------QQHTQVLFIAKITPNNNGTYACFVSN 659 C + P P Y W NG P Q L I + ++ G Y C N Sbjct: 314 WECKANGRPKPTYRWLKNGDPLLTRDRIQIEQGTLNITIVNLSDAGMYQCVAEN 367 Score = 64.3 bits (155), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 88/326 (26%), Positives = 123/326 (37%), Gaps = 36/326 (11%) Query: 104 NASLLIQNIIQ-NDTGFYTLHVIKS--DLVNEEATGQFRVYPELPKPSISSNNSKPVEDK 160 + SLLI N + D G Y S +V+ EA QF Y E K S S V Sbjct: 60 DGSLLINNPNKTQDAGTYQCIATNSFGTIVSREAKLQF-AYLENFKTRTRSTVS--VRRG 116 Query: 161 DAVAFTCEP--ETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ 218 + C P + + +Y W N R +S L + V ++D +Y C Sbjct: 117 QGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVT 176 Query: 219 NPVSAR-----------RSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPA 267 N V+ R+D V+ Y P P G + L C A NP Sbjct: 177 NTVTNHKVLGPPTPLILRNDGVMGE--YEPKIEVQFPETVPAEKGTTVKLECFALGNPVP 234 Query: 268 QYSW--------FVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVY 319 W +S L IPN ++GSY C A NS G N +T Y Sbjct: 235 TILWRRADGKPIARKARRHKSNGILEIPNFQQEDAGSYECVAENS-RGKN-VAKGQLTFY 292 Query: 320 AEPPKPFITSNNSNPVEDEDAVALTCEPEIQ-NTTYLWWVNNQSLPVSPRLQLSNDNRTL 378 A+P ++ N V E++V C+ + TY W N L R+Q+ + TL Sbjct: 293 AQPN--WVQIINDIHVAMEESVFWECKANGRPKPTYRWLKNGDPLLTRDRIQI--EQGTL 348 Query: 379 TLLSVTRNDVGPYECGIQNKLSVDHS 404 + V +D G Y+C +NK V S Sbjct: 349 NITIVNLSDAGMYQCVAENKHGVIFS 374 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 40/164 (24%), Positives = 63/164 (38%), Gaps = 20/164 (12%) Query: 515 DKDAVAFTCEPEAQNTTYLWW-VNGQSLPVSPRLQLSNGNRTLTLFNVTR-NDARAYVCG 572 ++ V +CE + ++ W +NG + + + S + +L + N + DA Y C Sbjct: 21 EEKKVKLSCEVKGNPKPHIRWKLNGTDVDIGMDFRYSVVDGSLLINNPNKTQDAGTYQCI 80 Query: 573 IQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQ-----YSW 627 NS S L Y + + S G + L C P P Y+W Sbjct: 81 ATNSFGTIVSREAKLQFAYLENFKTRTRSTVSVRRGQGMVLLC----GPPPHSGELSYAW 136 Query: 628 RINGIPQ---------QHTQVLFIAKITPNNNGTYACFVSNLAT 662 N P Q T L+IAK+ ++ G Y C V+N T Sbjct: 137 IFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVT 180 >5O5G-A nrPDB Length = 385 Score = 67.8 bits (164), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 90/358 (25%), Positives = 133/358 (37%), Gaps = 49/358 (13%) Query: 343 LTCEPEIQNTTYLWWVN-------NQSLPVSPRLQLSNDNRTLTLLSV-----TRNDVGP 390 L C+ E + T + W ++ P S R+ L + +L L + +R D G Sbjct: 25 LNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG--SLFFLRIVHGRKSRPDEGV 82 Query: 391 YECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHA-ASNPPAQYSW 449 Y C +N L S L V DD +PS G + C +P SW Sbjct: 83 YVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISW 142 Query: 450 LIDGN--------IQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELP 501 DG+ I +L I+ + ++G Y C N G + V +TV L Sbjct: 143 KKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV-GERESEVAELTV---LE 198 Query: 502 KPSISSNNSK-PVEDKDAVAFTCEPEAQNT-TYLWWVNGQSLPVSPRLQLSNGNRTLTLF 559 +PS S V D+ F CE T W + LP S R ++ + + TL + Sbjct: 199 RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRD-DHTLKIR 256 Query: 560 NVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSAS 619 VT D +Y C +N V + TL V P ++ P D G + C + Sbjct: 257 KVTAGDMGSYTCVAENMVGKAEAS-ATLTVQEPPHF-VVKPRDQVVALGRTVTFQCEATG 314 Query: 620 NPSPQYSWRINGI---------PQQHTQV-------LFIAKITPNNNGTYACFVSNLA 661 NP P WR G PQ ++ L I + ++ G Y C N+A Sbjct: 315 NPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVA 372 Score = 62.8 bits (151), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 75/333 (22%), Positives = 123/333 (36%), Gaps = 40/333 (12%) Query: 182 NQSLPVSPRLQLSNGNRTLTLFNV-----TRNDTASYKCETQNPVSARRSDSVILNVLYG 236 ++ P S R+ L +G +L + +R D Y C +N + S + L V Sbjct: 49 DKDDPRSHRMLLPSG--SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL 106 Query: 237 PDAPTISPLNTSYRSGENLNLSCHA-ASNPPAQYSWFVNGTFQQSTQE--------LFIP 287 D +P + GE + C +P SW +G+ E L I Sbjct: 107 RDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMIT 166 Query: 288 NITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEP 347 +++G Y C N G + V +TV P F+ ++ V +D+ CE Sbjct: 167 YTRKSDAGKYVCVGTNM-VGERESEVAELTVLERPS--FVKRPSNLAVTVDDSAEFKCEA 223 Query: 348 EIQNT-TYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDP 406 T W ++ LP S R ++ +D+ TL + VT D+G Y C +N + + Sbjct: 224 RGDPVPTVRWRKDDGELPKS-RYEIRDDH-TLKIRKVTAGDMGSYTCVAENMVGKAEASA 281 Query: 407 VILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQ---------- 456 + + P + P G ++ C A NP W +G+ Sbjct: 282 TL--TVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS 339 Query: 457 ------QHTQELFISNITEKNSGLYTCQANNSA 483 T +L I+N+ + G Y CQ N A Sbjct: 340 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVA 372 Score = 28.5 bits (62), Expect = 9.5, Method: Compositional matrix adjust. Identities = 33/131 (25%), Positives = 51/131 (38%), Gaps = 13/131 (9%) Query: 98 REIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPV 157 R I + +L I+ + D G YT V ++ + EA+ V + P + + V Sbjct: 244 RYEIRDDHTLKIRKVTAGDMGSYTC-VAENMVGKAEASATLTV--QEPPHFVVKPRDQVV 300 Query: 158 EDKDAVAFTCEPETQDATYLWWVNNQSLPV---------SPRLQLSNGNRTLTLFNVTRN 208 V F CE ++W S + S R +S LT+ NV R+ Sbjct: 301 ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRS 359 Query: 209 DTASYKCETQN 219 D Y C+T N Sbjct: 360 DVGYYICQTLN 370 >5Z5K-A nrPDB Length = 380 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 78/329 (23%), Positives = 128/329 (38%), Gaps = 39/329 (11%) Query: 98 REIIYPNASLLIQNIIQN-----DTGFYTLHVIKSD---LVNEEATGQFRVYPELPKPSI 149 R+ PN SLLIQNI+ + D G Y D +++ A +V P + Sbjct: 50 RKQQLPNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTA----KVMVAGPLRFL 105 Query: 150 SSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS----LPVSPRLQ-LSNGNRTLTLFN 204 S S D V CE + W NQ +P R+ L +G L + Sbjct: 106 SQTESITAFMGDTVLLKCEVIGDPMPTIHWQKNQQDLNPIPGDSRVVVLPSG--ALQISR 163 Query: 205 VTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTI-----SPLNTSYRSGENLNLSC 259 + D+ Y+C +NP S R + + +L P P N G++ L C Sbjct: 164 LQPGDSGVYRCSARNPASTRTGNEAEVRILSDPGLHRQLYFLQRPSNVIAIEGKDAVLEC 223 Query: 260 HAASNPPAQYSWFVNGTFQQSTQE---------LFIPNITVNNSGSYTCQAHNSDTGLNR 310 + PP ++W Q + L I N+T ++SG+YTC + ++ Sbjct: 224 CVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNENISA 283 Query: 311 TTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPV-SPRL 369 + T+ V PP +N E D + C + + W+ N + + S Sbjct: 284 SAELTVLV---PPWFLNHPSNLYAYESMD-IEFECAVSGKPVPTVNWMKNGDVVIPSDYF 339 Query: 370 QLSNDNRTLTLLSVTRNDVGPYECGIQNK 398 Q+ + L +L V ++D G Y+C +N+ Sbjct: 340 QIVGGS-NLRILGVVKSDEGFYQCVAENE 367 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 80/316 (25%), Positives = 119/316 (37%), Gaps = 41/316 (12%) Query: 293 NSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNT 352 + G Y C+A D+G T V P F++ S D V L CE Sbjct: 73 DEGLYQCEASLGDSG--SIISRTAKVMVAGPLRFLSQTESITAFMGDTVLLKCEVIGDPM 130 Query: 353 TYLWWVNNQSLPVSPRLQLSNDNRTLTL----LSVTR---NDVGPYECGIQNKLSVDHSD 405 + W NQ ++P + D+R + L L ++R D G Y C +N S + Sbjct: 131 PTIHWQKNQQ-DLNP---IPGDSRVVVLPSGALQISRLQPGDSGVYRCSARNPASTRTGN 186 Query: 406 PVILNVLYGPDDPTISPS-YTYYRP-------GVNLSLSCHAASNPPAQYSWLIDGNIQQ 457 + +L DP + Y RP G + L C + PP ++WL + Q Sbjct: 187 EAEVRIL---SDPGLHRQLYFLQRPSNVIAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQ 243 Query: 458 HTQE---------LFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSA-ELPKPSISS 507 + L ISN+T+ +SG YTC S + T+ V L PS Sbjct: 244 LRSKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNENISASAELTVLVPPWFLNHPS--- 300 Query: 508 NNSKPVEDKDAVAFTCEPEAQNT-TYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDA 566 N E D + F C + T W NG + S Q+ G+ L + V ++D Sbjct: 301 -NLYAYESMD-IEFECAVSGKPVPTVNWMKNGDVVIPSDYFQIVGGS-NLRILGVVKSDE 357 Query: 567 RAYVCGIQNSVSANRS 582 Y C +N +S Sbjct: 358 GFYQCVAENEAGNAQS 373 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 86/217 (39%), Gaps = 24/217 (11%) Query: 462 LFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAE--------LPKPSISSNNSKPV 513 L IS + +SG+Y C A N AS + + +S L +PS N + Sbjct: 159 LQISRLQPGDSGVYRCSARNPASTRTGNEAEVRILSDPGLHRQLYFLQRPS----NVIAI 214 Query: 514 EDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGI 573 E KDAV C ++ W + + + + G L + NVT +D+ Y C + Sbjct: 215 EGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGTYTC-V 273 Query: 574 QNSVSANRSDPVTLDVLYGPDTPIISPPDSSY-LSGANLNLSCHSASNPSPQYSWRING- 631 + N S L VL P ++ P + Y ++ C + P P +W NG Sbjct: 274 VTYKNENISASAELTVLVPP--WFLNHPSNLYAYESMDIEFECAVSGKPVPTVNWMKNGD 331 Query: 632 --IPQQHTQV-----LFIAKITPNNNGTYACFVSNLA 661 IP + Q+ L I + ++ G Y C N A Sbjct: 332 VVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEA 368 Score = 46.2 bits (108), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 63/272 (23%), Positives = 100/272 (36%), Gaps = 39/272 (14%) Query: 422 PSYTYYRPGVNLSLSCHAASNPPA-QYSWLIDGNI----------QQHTQELFISNITEK 470 PS G N+ L+C A S+ W DG I Q L I NI Sbjct: 8 PSDAVTMRGGNVLLNCSAESDRGVPVIKWKKDGLILALGMDDRKQQLPNGSLLIQNILHS 67 Query: 471 -----NSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEP 525 + GLY C+A+ SG + + V+ P +S S D V CE Sbjct: 68 RHHKPDEGLYQCEASLGDSGSIISRTAKVMVAG--PLRFLSQTESITAFMGDTVLLKCEV 125 Query: 526 EAQNTTYLWWVNGQS----LPVSPR-LQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSAN 580 + W Q +P R + L +G L + + D+ Y C +N S Sbjct: 126 IGDPMPTIHWQKNQQDLNPIPGDSRVVVLPSG--ALQISRLQPGDSGVYRCSARNPASTR 183 Query: 581 RSDPVTLDVLYGPDTP-----IISPPDSSYLSGANLNLSCHSASNPSPQYSW-RINGIPQ 634 + + +L P + P + + G + L C + P P ++W R + Q Sbjct: 184 TGNEAEVRILSDPGLHRQLYFLQRPSNVIAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQ 243 Query: 635 QHTQV--------LFIAKITPNNNGTYACFVS 658 ++ L I+ +T +++GTY C V+ Sbjct: 244 LRSKKYSLLGGSNLLISNVTDDDSGTYTCVVT 275 Score = 39.7 bits (91), Expect = 0.005, Method: Compositional matrix adjust. Identities = 57/234 (24%), Positives = 83/234 (35%), Gaps = 24/234 (10%) Query: 87 QQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVI--KSDLVNEEAT-------GQ 137 Q P P S R ++ P+ +L I + D+G Y S EA G Sbjct: 140 QDLNPIPGDS-RVVVLPSGALQISRLQPGDSGVYRCSARNPASTRTGNEAEVRILSDPGL 198 Query: 138 FRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGN 197 R L +PS N +E KDAV C ++ W + + + + G Sbjct: 199 HRQLYFLQRPS----NVIAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGG 254 Query: 198 RTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNL 257 L + NVT +D+ +Y C + S S L VL P P N ++ Sbjct: 255 SNLLISNVTDDDSGTYTCVVTYK-NENISASAELTVLVPPWFLN-HPSNLYAYESMDIEF 312 Query: 258 SCHAASNPPAQYSWFVNGT-------FQ-QSTQELFIPNITVNNSGSYTCQAHN 303 C + P +W NG FQ L I + ++ G Y C A N Sbjct: 313 ECAVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAEN 366 Score = 32.7 bits (73), Expect = 0.56, Method: Compositional matrix adjust. Identities = 52/217 (23%), Positives = 87/217 (40%), Gaps = 33/217 (15%) Query: 22 ASLLTFWNPPTTAKLTIESTPFNVA--EGKEVLL--LVHNLPQHLFGYSWYKGERVDGNR 77 A + +P +L P NV EGK+ +L V P F +W +GE V R Sbjct: 188 AEVRILSDPGLHRQLYFLQRPSNVIAIEGKDAVLECCVSGYPPPSF--TWLRGEEVIQLR 245 Query: 78 QIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVI-KSDLVNEEATG 136 S + + ++LLI N+ +D+G YT V K++ ++ A Sbjct: 246 ------------------SKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNENISASAEL 287 Query: 137 QFRVYP-ELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPV-SPRLQLS 194 V P L PS N E D + F C + + W+ N + + S Q+ Sbjct: 288 TVLVPPWFLNHPS----NLYAYESMD-IEFECAVSGKPVPTVNWMKNGDVVIPSDYFQIV 342 Query: 195 NGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVIL 231 G+ L + V ++D Y+C +N +S + ++ Sbjct: 343 GGS-NLRILGVVKSDEGFYQCVAENEAGNAQSSAQLI 378 >6IAA-A nrPDB Length = 859 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 107/494 (21%), Positives = 172/494 (34%), Gaps = 74/494 (14%) Query: 244 PLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQE-------------LFIPNIT 290 P + GE L+C A P W+ +G ++ ++ LF I Sbjct: 27 PSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIV 86 Query: 291 VN-----NSGSYTCQAHNS-DTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALT 344 + GSY C A N ++R + + + F + V + L Sbjct: 87 HGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRD---DFRQNPTDVVVAAGEPAILE 143 Query: 345 CEPEIQN-TTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDH 403 C+P + ++W ++ ++S L + + ++D G Y C N + Sbjct: 144 CQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERD 203 Query: 404 SDPVILNVLYGPDDPTISPSYTYYRPGVN--------LSLSCHAASNPPAQYSWLID--- 452 SDP L V P T+ R +N + C +P W D Sbjct: 204 SDPAELTVFERP---------TFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDAD 254 Query: 453 ---GNIQ-QHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSN 508 G + L I + G Y C A N + T+TV A P + Sbjct: 255 LPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASA--TLTVRA--PPQFVVRP 310 Query: 509 NSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQS----LPVSPRLQLSNGNRT----LTLFN 560 + V V F CE + ++W S P P+ S + + LT+ N Sbjct: 311 RDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITN 370 Query: 561 VTRNDARAYVCG---IQNSVSANRSDPVTLDVLYGPDTPII--SPPDSSYLSGANLNLSC 615 + R+DA Y+C + S+ A VT DVL PII P + + L C Sbjct: 371 IQRSDAGYYICQALTVAGSILAKAQLEVT-DVLTDRPPPIILQGPANQTLAVDGTALLKC 429 Query: 616 HSASNPSPQYSWRINGI------PQ---QHTQVLFIAKITPNNNGTYACFVSNLATGRNN 666 + +P P SW G P+ Q L I + ++ GTY C ++ + + Sbjct: 430 KATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSW 489 Query: 667 SIVKSITVSASGTS 680 S V +T S + S Sbjct: 490 SAVLDVTESGATIS 503 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 86/350 (24%), Positives = 130/350 (37%), Gaps = 61/350 (17%) Query: 190 RLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTI--SPLNT 247 R+ + G L + N ++D Y C N V R SD L V + PT P+N Sbjct: 170 RISIRGGK--LMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVF---ERPTFLRRPINQ 224 Query: 248 SYRSGENLNLSCHAASNPPAQYSW------FVNGTFQ-QSTQELFIPNITVNNSGSYTCQ 300 E + C +P W G + + L I + G+Y C Sbjct: 225 VVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCI 284 Query: 301 AHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNN 360 A N + + T+TV A PP+ F+ V V CE + ++W Sbjct: 285 AENRVGKMEASA--TLTVRA-PPQ-FVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKE 340 Query: 361 QSL-------PVSPRLQLS-NDNRTLTLLSVTRNDVGPYEC-------GIQNKLSVDHSD 405 S P P + S + LT+ ++ R+D G Y C I K ++ +D Sbjct: 341 GSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTD 400 Query: 406 -------PVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDG----- 453 P+IL GP + T++ T L C A +P SWL +G Sbjct: 401 VLTDRPPPIILQ---GPANQTLAVDGTAL-------LKCKATGDPLPVISWLKEGFTFPG 450 Query: 454 -----NIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSA 498 IQ+ L I N+ ++G YTC A +S+ S + V +T S Sbjct: 451 RDPRATIQEQGT-LQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESG 499 >6DLD-B nrPDB Length = 304 Score = 63.2 bits (152), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 60/219 (27%), Positives = 92/219 (42%), Gaps = 23/219 (10%) Query: 276 TFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPV 335 T + L I N+ V + G YTC T RT +TV PPK + SN+ V Sbjct: 69 TLNKRDYSLQIQNVDVTDDGPYTCSVQTQHT--PRTMQVHLTVQV-PPKIYDISNDMT-V 124 Query: 336 EDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGI 395 + V LTC + + W + +SP + + + L + +TR+ G YEC Sbjct: 125 NEGTNVTLTCLATGKPEPSISWRH-----ISPSAKPFENGQYLDIYGITRDQAGEYECSA 179 Query: 396 QNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSW------ 449 +N +S V + V + P I PG + + C A PP + W Sbjct: 180 ENDVSFPDVRKVKVVVNFAPTIQEIKSGTV--TPGRSGLIRCEGAGVPPPAFEWYKGEKK 237 Query: 450 LIDGN----IQQHTQE--LFISNITEKNSGLYTCQANNS 482 L +G IQ + L ++N+T+++ G YTC A N Sbjct: 238 LFNGQQGIIIQNFSTRSILTVTNVTQEHFGNYTCVAANK 276 Score = 52.8 bits (125), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 56/216 (25%), Positives = 90/216 (41%), Gaps = 32/216 (14%) Query: 106 SLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAF 165 SL IQN+ D G YT V + T Q + ++P +N V + V Sbjct: 76 SLQIQNVDVTDDGPYTCSV---QTQHTPRTMQVHLTVQVPPKIYDISNDMTVNEGTNVTL 132 Query: 166 TCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVS--A 223 TC + + W + +SP + + L ++ +TR+ Y+C +N VS Sbjct: 133 TCLATGKPEPSISWRH-----ISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPD 187 Query: 224 RRSDSVILNVLYGPDAPTISPLNTSYRS-GENLNLSCHAASNPPAQYSWF------VNGT 276 R V++N APTI + + + G + + C A PP + W+ NG Sbjct: 188 VRKVKVVVNF-----APTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNG- 241 Query: 277 FQQ-------STQELF-IPNITVNNSGSYTCQAHNS 304 QQ ST+ + + N+T + G+YTC A N Sbjct: 242 -QQGIIIQNFSTRSILTVTNVTQEHFGNYTCVAANK 276 Score = 50.4 bits (119), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 69/268 (25%), Positives = 101/268 (37%), Gaps = 37/268 (13%) Query: 157 VEDKDAVAFTCEPETQDATYLWWVNNQSL--------PVSPRLQLSNGNR---TLTLFNV 205 V D C E A+ W+N S+ V PR+ +S N+ +L + NV Sbjct: 24 VRKGDTAVLRCYLE-DGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNV 82 Query: 206 TRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNP 265 D Y C Q + R + V L V P IS + + G N+ L+C A P Sbjct: 83 DVTDDGPYTCSVQTQHTPR-TMQVHLTVQVPPKIYDISN-DMTVNEGTNVTLTCLATGKP 140 Query: 266 PAQYSW---------FVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTI 316 SW F NG Q L I IT + +G Y C A N + + V + Sbjct: 141 EPSISWRHISPSAKPFENG------QYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVV 194 Query: 317 TVYAEPPKPFITSNNSNPVEDEDAVALTCE-PEIQNTTYLWWVNNQSLPVSPR---LQLS 372 +A P I S V + + CE + + W+ + L + +Q Sbjct: 195 VNFA----PTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQNF 250 Query: 373 NDNRTLTLLSVTRNDVGPYECGIQNKLS 400 + LT+ +VT+ G Y C NKL Sbjct: 251 STRSILTVTNVTQEHFGNYTCVAANKLG 278 Score = 48.5 bits (114), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 45/160 (28%), Positives = 63/160 (39%), Gaps = 15/160 (9%) Query: 513 VEDKDAVAFTCEPEAQNTTYLW-------WVNGQSLPVSPRLQLSNGNR---TLTLFNVT 562 V D C E + W + G V PR+ +S N+ +L + NV Sbjct: 24 VRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNVD 83 Query: 563 RNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPS 622 D Y C +Q + R+ V L V P IS D + G N+ L+C + P Sbjct: 84 VTDDGPYTCSVQTQHTP-RTMQVHLTVQVPPKIYDISN-DMTVNEGTNVTLTCLATGKPE 141 Query: 623 PQYSWRI---NGIPQQHTQVLFIAKITPNNNGTYACFVSN 659 P SWR + P ++ Q L I IT + G Y C N Sbjct: 142 PSISWRHISPSAKPFENGQYLDIYGITRDQAGEYECSAEN 181 Score = 45.4 bits (106), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 49/219 (22%), Positives = 85/219 (38%), Gaps = 23/219 (10%) Query: 462 LFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAF 521 L I N+ + G YTC H+ T++ + ++ ++P +N V + V Sbjct: 77 LQIQNVDVTDDGPYTCSVQTQ---HTPRTMQ-VHLTVQVPPKIYDISNDMTVNEGTNVTL 132 Query: 522 TCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANR 581 TC + + W + +SP + + L ++ +TR+ A Y C +N VS Sbjct: 133 TCLATGKPEPSISWRH-----ISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPD 187 Query: 582 SDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWR------ING---- 631 V + V + P I + G + + C A P P + W NG Sbjct: 188 VRKVKVVVNFAPTIQEIK--SGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGI 245 Query: 632 IPQQHT--QVLFIAKITPNNNGTYACFVSNLATGRNNSI 668 I Q + +L + +T + G Y C +N N S+ Sbjct: 246 IIQNFSTRSILTVTNVTQEHFGNYTCVAANKLGTTNASL 284 >3V2A-R nrPDB Length = 772 Score = 56.2 bits (134), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 107/475 (22%), Positives = 177/475 (37%), Gaps = 107/475 (22%) Query: 96 SGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSK 155 SG E+ ++L I + ++D G YT S L+ ++ + RV+ E P + S Sbjct: 281 SGSEMKKFLSTLTIDGVTRSDQGLYTCAA-SSGLMTKKNSTFVRVH-EKPFVAFGSGMES 338 Query: 156 PVEDKDAVAFTCEPETQDATYL--------WWVNNQSLPVSPRLQLSNGNRTLTLFNVTR 207 VE A E A YL W+ N +P+ + G+ LT+ V+ Sbjct: 339 LVE-----ATVGERVRIPAKYLGYPPPEIKWYKNG--IPLESNHTIKAGH-VLTIMEVSE 390 Query: 208 NDTASYKCETQNPVSARRSDSVILNVLYGP----DAPTISPLNTSYRSGENLNLSCHAAS 263 DT +Y NP+S + V+ V+Y P + ISP++ SY+ G L+C + Sbjct: 391 RDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVD-SYQYGTTQTLTCTVYA 449 Query: 264 NPPAQY-SWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNS------------------ 304 PP + W+ +Q + P+ V+ + Y C+ S Sbjct: 450 IPPPHHIHWY----WQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFA 505 Query: 305 -DTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAV---------ALTCEPEI----Q 350 G N+ TV+T+ + A N V + V +T +P++ Q Sbjct: 506 LIEGKNK-TVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQ 564 Query: 351 NTTYLWWVNNQS-----------------------LPVSPRL---------QLSN---DN 375 + LW ++S PV L SN D Sbjct: 565 ESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDI 624 Query: 376 RTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRP--GVNL 433 + L + + D G Y C Q++ + V + PTI+ + G ++ Sbjct: 625 LIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESI 684 Query: 434 SLSCHAASNPPAQYSWLIDGN---------IQQHTQELFISNITEKNSGLYTCQA 479 +SC A+ NPP Q W D ++ + L I + +++ GLYTCQA Sbjct: 685 EVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQA 739 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 94/398 (23%), Positives = 152/398 (38%), Gaps = 69/398 (17%) Query: 274 NGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPK-PFITSNNS 332 +G F ++ L IP + N++G+Y C +D + I VY + + PFI S Sbjct: 81 DGLFCKT---LTIPKVIGNDTGAYKCFYRETDLA------SVIYVYVQDYRSPFIAS--- 128 Query: 333 NPVEDEDAVALTCEPEIQNTTY--LWWVNNQSLPVSPRL----------QLSNDNRT-LT 379 V D+ V E + + L ++N ++ + R ++S D++ T Sbjct: 129 --VSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFT 186 Query: 380 LLSVTRNDVGPYECGIQ-NKLSVDHSDPVILNVLYGPDDPTISPSY-TYYRPGVNLSLSC 437 + S + G C + N S +++ V Y D +SPS+ G L L+C Sbjct: 187 IPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNC 246 Query: 438 HAAS--NPPAQYSWLIDGNIQQHTQ-------------------ELFISNITEKNSGLYT 476 A + N ++W + QH + L I +T + GLYT Sbjct: 247 TARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYT 306 Query: 477 CQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTY---- 532 C A +SG T E P + S VE V A+ Y Sbjct: 307 CAA---SSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEA--TVGERVRIPAKYLGYPPPE 361 Query: 533 -LWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLY 591 W+ NG +P+ + G+ LT+ V+ D Y + N +S + V V+Y Sbjct: 362 IKWYKNG--IPLESNHTIKAGH-VLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVY 418 Query: 592 GP----DTPIISPPDSSYLSGANLNLSCHSASNPSPQY 625 P + +ISP D SY G L+C + P P + Sbjct: 419 VPPQIGEKSLISPVD-SYQYGTTQTLTCTVYAIPPPHH 455 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 143/687 (20%), Positives = 244/687 (35%), Gaps = 173/687 (25%) Query: 106 SLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAF 165 +L I +I NDTG Y ++DL A+ + + P I+S V D+ V + Sbjct: 87 TLTIPKVIGNDTGAYKCFYRETDL----ASVIYVYVQDYRSPFIAS-----VSDQHGVVY 137 Query: 166 TCEPETQDATY--LWWVNNQSLPVSPRLQ----LSNGNRT-------LTLFNVTRNDTAS 212 E + + L ++N ++ + R + +GNR T+ + + Sbjct: 138 ITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGM 197 Query: 213 YKCETQ-NPVSARRSDSVILNVLYGPDAPTISPLNTSYRS-GENLNLSCHAAS--NPPAQ 268 CE + N S + +++ V Y +SP + S GE L L+C A + N Sbjct: 198 VFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGID 257 Query: 269 YSW-----------FVNGTFQ-QSTQE-------LFIPNITVNNSGSYTCQAHNSDTGLN 309 ++W VN + QS E L I +T ++ G YTC A S + Sbjct: 258 FNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAA--SSGLMT 315 Query: 310 RTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCE----------PEIQNTTYLWWVN 359 + T + V+ KPF+ + E V PEI+ W+ N Sbjct: 316 KKNSTFVRVHE---KPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIK-----WYKN 367 Query: 360 NQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGP---- 415 L + ++ + LT++ V+ D G Y + N +S + V+ V+Y P Sbjct: 368 GIPLESNHTIKAGH---VLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIG 424 Query: 416 DDPTISP--SYTYYRPGVNLSLSCHAASNPP---AQYSWLIDGNIQQH-TQELFISN--- 466 + ISP SY Y G +L+C + PP + W ++ +Q + ++N Sbjct: 425 EKSLISPVDSYQY---GTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYP 481 Query: 467 -------------------------ITEKN-------------SGLYTCQANNSASGHSR 488 I KN S LY C+A N R Sbjct: 482 CEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGER 541 Query: 489 TTVKTITVSAELP-KPSISSNNSKPVEDKDAVAFTC------------------------ 523 +T E+ +P + +P E +++V+ C Sbjct: 542 VISFHVTRGPEITLQPDM-----QPTE-QESVSLWCTADRSTFENLTWYKLGPQPLPIHV 595 Query: 524 ----EPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSA 579 P +N LW +N S +N + L N + D YVC Q+ + Sbjct: 596 GELPTPVCKNLDTLWKLNATMFSNS-----TNDILIMELKNASLQDQGDYVCLAQDRKTK 650 Query: 580 NRSDPVTLDVLYGPDTPIISP--PDSSYLSGANLNLSCHSASNPSPQYSWRING------ 631 R V + P I+ + + G ++ +SC ++ NP PQ W + Sbjct: 651 KRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVED 710 Query: 632 ---IPQQHTQVLFIAKITPNNNGTYAC 655 + + + L I ++ + G Y C Sbjct: 711 SGIVLKDGNRNLTIRRVRKEDEGLYTC 737 Score = 38.5 bits (88), Expect = 0.009, Method: Compositional matrix adjust. Identities = 81/402 (20%), Positives = 151/402 (37%), Gaps = 62/402 (15%) Query: 143 ELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGN----- 197 +LP+ SI + ++ + TC + +D +LW NNQS R++++ + Sbjct: 30 DLPRLSIQ-KDILTIKANTTLQITCRGQ-RDLDWLW-PNNQS-GSEQRVEVTECSDGLFC 85 Query: 198 RTLTLFNVTRNDTASYKC----------------ETQNPVSARRSDSVILNVLYGPDAPT 241 +TLT+ V NDT +YKC + ++P A SD V+Y + Sbjct: 86 KTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQ--HGVVYITENKN 143 Query: 242 ISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQA 301 + + S NLN+S A P ++ N S + IP+ ++ +G C+A Sbjct: 144 KTVVIPCLGSISNLNVSL-CARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEA 202 Query: 302 HNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQ---NTTYLW-- 356 +D + V ++ ++ + + + L C + + W Sbjct: 203 KINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEY 262 Query: 357 --------WVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVD------ 402 + N+ L ++ TLT+ VTR+D G Y C + L Sbjct: 263 PSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFV 322 Query: 403 --HSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDG------N 454 H P V +G ++ + G + + PP + W +G + Sbjct: 323 RVHEKPF---VAFGSGMESLVEATV----GERVRIPAKYLGYPPPEIKWYKNGIPLESNH 375 Query: 455 IQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITV 496 + L I ++E+++G YT N S ++ V ++ V Sbjct: 376 TIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVV 417 Score = 37.0 bits (84), Expect = 0.031, Method: Compositional matrix adjust. Identities = 33/128 (25%), Positives = 54/128 (42%), Gaps = 9/128 (7%) Query: 555 TLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLS--GANLN 612 TLT+ VTR+D Y C + + + + + V P S +S + G + Sbjct: 291 TLTIDGVTRSDQGLYTCAASSGL-MTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVR 349 Query: 613 LSCHSASNPSPQYSWRINGIPQQ--HT----QVLFIAKITPNNNGTYACFVSNLATGRNN 666 + P P+ W NGIP + HT VL I +++ + G Y ++N + Sbjct: 350 IPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQ 409 Query: 667 SIVKSITV 674 S V S+ V Sbjct: 410 SHVVSLVV 417 >2WIM-A nrPDB Length = 291 Score = 55.5 bits (132), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 60/218 (27%), Positives = 89/218 (40%), Gaps = 23/218 (10%) Query: 104 NASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELP-KPSISSNNSKPVEDKDA 162 + L I N D G Y + +EAT +Y +L + +S K ED + Sbjct: 59 RSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEV 118 Query: 163 VAFTCEPETQDATYLWWV--NNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNP 220 V C + A + W+ N + +S N L + N+ ++D Y+CE + Sbjct: 119 V---CRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGR-- 173 Query: 221 VSAR-----RSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNG 275 V AR R VI+NV P S N + GE + SC A+ +P SWF NG Sbjct: 174 VEARGEIDFRDIIVIVNVPPAISMPQKS-FNATAERGEEMTFSCRASGSPEPAISWFRNG 232 Query: 276 T---------FQQSTQELFIPNITVNNSGSYTCQAHNS 304 + S EL + NI ++ G Y C+A N Sbjct: 233 KLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNK 270 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 67/287 (23%), Positives = 108/287 (37%), Gaps = 41/287 (14%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFV-NGTFQQSTQE-----------LFIPN 288 TIS GE+ +C A P + W+ G STQ L I N Sbjct: 8 TISLSKVELSVGESKFFTCTAIGEPES-IDWYNPQGEKIISTQRVVVQKEGVRSRLTIYN 66 Query: 289 ITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPE 348 + ++G Y CQA ++ TV + ++ ED + V Sbjct: 67 ANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSP 126 Query: 349 IQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTL-------LSVTRNDVGPYECG--IQNKL 399 ++L+ N + +S DNR L L++ ++D G Y C ++ + Sbjct: 127 APAVSWLYH-NEEVTTIS-------DNRFAMLANNNLQILNINKSDEGIYRCEGRVEARG 178 Query: 400 SVDHSD-PVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQH 458 +D D VI+NV P S + T R G ++ SC A+ +P SW +G + + Sbjct: 179 EIDFRDIIVIVNVPPAISMPQKSFNATAER-GEEMTFSCRASGSPEPAISWFRNGKLIEE 237 Query: 459 TQ---------ELFISNITEKNSGLYTCQANNSASGHSRTTVKTITV 496 + EL + NI + G Y C+A N A + + V Sbjct: 238 NEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV 284 Score = 45.4 bits (106), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 48/223 (21%), Positives = 83/223 (37%), Gaps = 30/223 (13%) Query: 378 LTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPD-DPTISPSYTYYRPGVNLSLS 436 LT+ + D G Y C + V+L + +SP ++ G + + Sbjct: 62 LTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQE--FKQGEDAEVV 119 Query: 437 CHAASNPPAQYSWLIDGNIQQHTQELF-ISN---------------ITEKNSGLYTCQAN 480 C +S+P SWL H +E+ IS+ I + + G+Y C+ Sbjct: 120 CRVSSSPAPAVSWLY------HNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGR 173 Query: 481 NSASGH--SRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQ-NTTYLWWVN 537 A G R + + V + P S N + E + + F+C W+ N Sbjct: 174 VEARGEIDFRDIIVIVNVPPAISMPQKSFNAT--AERGEEMTFSCRASGSPEPAISWFRN 231 Query: 538 GQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSAN 580 G+ + + + L N LT+ N+ +D YVC N + Sbjct: 232 GKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGED 274 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 52/215 (24%), Positives = 89/215 (41%), Gaps = 20/215 (9%) Query: 462 LFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELP-KPSISSNNSKPVEDKDAVA 520 L I N +++G+Y CQA + A G ++ + + +L + +S K ED + V Sbjct: 62 LTIYNANIEDAGIYRCQATD-AKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVC 120 Query: 521 FTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSAN 580 A ++L+ N + +S N L + N+ ++D Y C + V A Sbjct: 121 RVSSSPAPAVSWLYH-NEEVTTISDNRFAMLANNNLQILNINKSDEGIYRC--EGRVEA- 176 Query: 581 RSDPVTLDVLYGPDTP-IISPPDSSY----LSGANLNLSCHSASNPSPQYSWRING---- 631 R + D++ + P IS P S+ G + SC ++ +P P SW NG Sbjct: 177 RGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIE 236 Query: 632 -----IPQQHTQVLFIAKITPNNNGTYACFVSNLA 661 I + L + I ++ G Y C +N A Sbjct: 237 ENEKYILKGSNTELTVRNIINSDGGPYVCRATNKA 271 >6DLF-A nrPDB Length = 306 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 65/279 (23%), Positives = 114/279 (40%), Gaps = 47/279 (16%) Query: 246 NTSYRSGENLNLSCHAASNPPAQYSWFVNGTF-------------------QQSTQELFI 286 N + R GE+ L C N + +W T Q+ + I Sbjct: 22 NVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 80 Query: 287 PNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCE 346 N+ V + G YTC + +T+ + V P I+S+ S + + + ++LTC Sbjct: 81 QNVDVYDEGPYTCSVQTDNHP--KTSRVHLIVQVSPKIVEISSDIS--INEGNNISLTCI 136 Query: 347 PEIQNTTYLWWVNNQSLPVSPR-LQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSD 405 + + W + +SP+ + +++ L + +TR G YEC N ++ Sbjct: 137 ATGRPEPTVTWRH-----ISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVR 191 Query: 406 PVILNVLYGPDDPTISPSYTYYRP-GVNLSLSCHAASNPPAQYSW------LIDGNIQQH 458 V + V Y P IS + P G +L C A++ P A++ W LI+G Sbjct: 192 RVKVTVNY---PPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVK 248 Query: 459 TQ------ELFISNITEKNSGLYTCQANNSASGHSRTTV 491 + +L N++E + G YTC A+N GH+ ++ Sbjct: 249 VENRPFLSKLIFFNVSEHDYGNYTCVASNKL-GHTNASI 286 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/213 (22%), Positives = 92/213 (43%), Gaps = 25/213 (11%) Query: 106 SLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAF 165 S+ IQN+ D G YT V ++D N T + + ++ + ++ + + + ++ Sbjct: 77 SIEIQNVDVYDEGPYTCSV-QTD--NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISL 133 Query: 166 TCEPETQDATYLWWVNNQSLPVSPR-LQLSNGNRTLTLFNVTRNDTASYKCETQNPVSAR 224 TC + + W + +SP+ + + + L + +TR + Y+C N V+A Sbjct: 134 TCIATGRPEPTVTWRH-----ISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAP 188 Query: 225 RSDSVILNVLYGPDAPTISPLN-TSYRSGENLNLSCHAASNPPAQYSWF------VNGTF 277 V + V Y P IS T G+ L C A++ P A++ W+ + G Sbjct: 189 VVRRVKVTVNY---PPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKK 245 Query: 278 QQSTQ------ELFIPNITVNNSGSYTCQAHNS 304 + +L N++ ++ G+YTC A N Sbjct: 246 GVKVENRPFLSKLIFFNVSEHDYGNYTCVASNK 278 Score = 37.0 bits (84), Expect = 0.028, Method: Compositional matrix adjust. Identities = 42/175 (24%), Positives = 73/175 (41%), Gaps = 17/175 (9%) Query: 529 NTTYLWWVNGQSLPVSPRLQLSNGNRT---LTLFNVTRNDARAYVCGIQNSVSANRSDPV 585 N + + + + PR+ L + +T + + NV D Y C +Q + ++ V Sbjct: 48 NRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEIQNVDVYDEGPYTCSVQTD-NHPKTSRV 106 Query: 586 TLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWR------INGIPQQHTQV 639 L V P IS D S G N++L+C + P P +WR + + + + Sbjct: 107 HLIVQVSPKIVEISS-DISINEGNNISLTCIATGRPEPTVTWRHISPKAVGFVSED--EY 163 Query: 640 LFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSAGATVGIMIG 694 L I IT +G Y C SN +V+ + V+ + P +S G+ +G Sbjct: 164 LEIQGITREQSGDYECSASNDVAA---PVVRRVKVTVN-YPPYISEAKGTGVPVG 214 >3K0W-A nrPDB Length = 218 Score = 52.4 bits (124), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 45/181 (24%), Positives = 70/181 (38%), Gaps = 26/181 (14%) Query: 510 SKPVEDKDAVAFTCEPEAQ-NTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFN-VTRNDAR 567 SK V V C Y W+ + +P NGN + +FN V DA Sbjct: 27 SKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIP--------NGNTSELIFNAVHVKDAG 78 Query: 568 AYVCGIQNSVSANRSDPVTLDVLYGPDT--------------PIISPPDSSYLSGANLNL 613 YVC + N+ + S LDV P++ + P + G+ L L Sbjct: 79 FYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVL 138 Query: 614 SCHSASNPSPQYSWRINGIPQQH--TQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKS 671 C + +P P Y W N +P H ++ + + + GTY C V N +++ V+ Sbjct: 139 QCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEI 198 Query: 672 I 672 I Sbjct: 199 I 199 Score = 45.8 bits (107), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 38/158 (24%), Positives = 60/158 (37%), Gaps = 25/158 (15%) Query: 176 YLWWVNNQSLPVSPRLQLSNGNRTLTLFN-VTRNDTASYKCETQNPVSARRSDSVILNVL 234 Y W+ N+ +P NGN + +FN V D Y C N + S L+V Sbjct: 50 YQWFKMNKEIP--------NGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVC 101 Query: 235 YGPDA--------------PTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGT-FQQ 279 P++ + P + G L L C A +P Y WF N Sbjct: 102 DIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTH 161 Query: 280 STQELF-IPNITVNNSGSYTCQAHNSDTGLNRTTVTTI 316 T++L+ +P + + + G+Y C +N + V I Sbjct: 162 ETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEII 199 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 37/72 (51%), Gaps = 10/72 (13%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFV------NGTFQQSTQELFIPNITVNNS 294 T++P + + +G+ + L C A +P QY WF NG +T EL + V ++ Sbjct: 22 TVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNG----NTSELIFNAVHVKDA 77 Query: 295 GSYTCQAHNSDT 306 G Y C+ +N+ T Sbjct: 78 GFYVCRVNNNFT 89 Score = 37.7 bits (86), Expect = 0.018, Method: Compositional matrix adjust. Identities = 20/65 (30%), Positives = 32/65 (49%), Gaps = 2/65 (3%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQYSWL-IDGNI-QQHTQELFISNITEKNSGLYT 476 T++P G + L C A +P QY W ++ I +T EL + + K++G Y Sbjct: 22 TVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYV 81 Query: 477 CQANN 481 C+ NN Sbjct: 82 CRVNN 86 Score = 36.6 bits (83), Expect = 0.039, Method: Compositional matrix adjust. Identities = 38/174 (21%), Positives = 63/174 (36%), Gaps = 30/174 (17%) Query: 341 VALTC----EPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQ 396 V L C P +Q Y W+ N+ +P + + L +V D G Y C + Sbjct: 36 VKLCCRATGHPFVQ---YQWFKMNKEIP-------NGNTSELIFNAVHVKDAGFYVCRVN 85 Query: 397 NKLSVDHSDPVILNVLYGPD--------------DPTISPSYTYYRPGVNLSLSCHAASN 442 N + + S L+V P+ + P+ PG L L C A + Sbjct: 86 NNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGS 145 Query: 443 PPAQYSWLIDGN-IQQHTQELF-ISNITEKNSGLYTCQANNSASGHSRTTVKTI 494 P Y W + + T++L+ + + ++ G Y C N V+ I Sbjct: 146 PIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVEII 199 Score = 35.4 bits (80), Expect = 0.075, Method: Compositional matrix adjust. Identities = 19/64 (29%), Positives = 32/64 (50%), Gaps = 2/64 (3%) Query: 598 ISPPDSSYLSGANLNLSCHSASNPSPQYSW-RING-IPQQHTQVLFIAKITPNNNGTYAC 655 ++P + L+G + L C + +P QY W ++N IP +T L + + G Y C Sbjct: 23 VNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVC 82 Query: 656 FVSN 659 V+N Sbjct: 83 RVNN 86 >1QZ1-A nrPDB Length = 291 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 55/226 (24%), Positives = 90/226 (39%), Gaps = 37/226 (16%) Query: 105 ASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDK---D 161 ++L I N +D G Y V D EAT +++ +L + N P E K D Sbjct: 62 STLTIYNANIDDAGIYKCVVTAEDGTQSEATVNVKIFQKL----MFKNAPTPQEFKEGED 117 Query: 162 AVAFTCEPETQDATYLWWVNNQSLPVSPRLQ-LSNGNRTLTLFNVTRNDTASYKCETQNP 220 AV + T +W + + + ++ + N L + + + D +Y+CE + Sbjct: 118 AVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGR-- 175 Query: 221 VSAR-----RSDSVILNVLYGPDAPTI----SPLNTSYRSGENLNLSCHAASNPPAQYSW 271 + AR + VI+NV PT+ S +N + G+++ L C A P SW Sbjct: 176 ILARGEINFKDIQVIVNV-----PPTVQARQSIVNATANLGQSVTLVCDADGFPEPTMSW 230 Query: 272 FVNG-------------TFQQSTQELFIPNITVNNSGSYTCQAHNS 304 +G F + EL I N+ N+ Y C A N Sbjct: 231 TKDGEPIENEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENK 276 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 48/229 (20%), Positives = 94/229 (41%), Gaps = 34/229 (14%) Query: 372 SNDNRTLTLLSVTRNDVGPYEC------GIQNKLSVDHSDPVILNVLYGPDDPTISPSYT 425 +D+ TLT+ + +D G Y+C G Q++ +V+ + +++ +P+ Sbjct: 58 DDDSSTLTIYNANIDDAGIYKCVVTAEDGTQSEATVNVK--IFQKLMFKN-----APTPQ 110 Query: 426 YYRPGVNLSLSCHAASNPPAQYSWLIDGN---IQQHTQELFISN-------ITEKNSGLY 475 ++ G + + C S+ P W G +++ + + +SN I + + G Y Sbjct: 111 EFKEGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTY 170 Query: 476 TCQANNSASGHSRTTVKTITVSAELPKPSISSNNS---KPVEDKDAVAFTCEPEAQ-NTT 531 C+ A G K I V +P P++ + S +V C+ + T Sbjct: 171 RCEGRILARGE--INFKDIQVIVNVP-PTVQARQSIVNATANLGQSVTLVCDADGFPEPT 227 Query: 532 YLWWVNGQSLP----VSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNS 576 W +G+ + + S+ + LT+ NV +ND YVC +N Sbjct: 228 MSWTKDGEPIENEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENK 276 Score = 38.9 bits (89), Expect = 0.008, Method: Compositional matrix adjust. Identities = 58/266 (21%), Positives = 102/266 (38%), Gaps = 43/266 (16%) Query: 165 FTCE--PETQDATYLWWV-NNQSL-PVSPRLQL---SNGNRTLTLFNVTRNDTASYKCET 217 F C+ + +D W+ N + L P R+ + + + TLT++N +D YKC Sbjct: 22 FLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLTIYNANIDDAGIYKCVV 81 Query: 218 QNPVSARRSDSV---ILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN 274 + +V I L +APT ++ GE+ + C S+ P W Sbjct: 82 TAEDGTQSEATVNVKIFQKLMFKNAPT----PQEFKEGEDAVIVCDVVSSLPPTIIWKHK 137 Query: 275 G---TFQQSTQELFIPN-------ITVNNSGSYTCQAHNSDTG-LNRTTVTTI-----TV 318 G ++ + + + N I + G+Y C+ G +N + I TV Sbjct: 138 GRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTV 197 Query: 319 YAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQ------LS 372 A T+N +V L C+ + + W + P+ + S Sbjct: 198 QARQSIVNATANLGQ------SVTLVCDADGFPEPTMSWTKDGE-PIENEEEDDEKHIFS 250 Query: 373 NDNRTLTLLSVTRNDVGPYECGIQNK 398 +D+ LT+ +V +ND Y C +NK Sbjct: 251 DDSSELTIRNVDKNDEAEYVCIAENK 276 Score = 32.0 bits (71), Expect = 0.89, Method: Compositional matrix adjust. Identities = 47/226 (20%), Positives = 83/226 (36%), Gaps = 24/226 (10%) Query: 462 LFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAF 521 L I N ++G+Y C S TV + K + + K E +DAV Sbjct: 64 LTIYNANIDDAGIYKCVVTAEDGTQSEATVNVKIFQKLMFKNAPTPQEFK--EGEDAVIV 121 Query: 522 TCEPEAQNTTYLWWVNGQSLPVSPRLQ-LSNGNRTLTLFNVTRNDARAYVCGIQNSVSAN 580 + T +W G+ + + ++ + N L + + + D Y C + + A Sbjct: 122 CDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC--EGRILA- 178 Query: 581 RSDPVTLDVLYGPDTPIISPPDSSYLS-----GANLNLSCHSASNPSPQYSWRINGIP-- 633 R + D+ + P S ++ G ++ L C + P P SW +G P Sbjct: 179 RGEINFKDIQVIVNVPPTVQARQSIVNATANLGQSVTLVCDADGFPEPTMSWTKDGEPIE 238 Query: 634 ------QQH-----TQVLFIAKITPNNNGTYACFVSNLATGRNNSI 668 ++H + L I + N+ Y C N A ++ SI Sbjct: 239 NEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQDASI 284 >3V6B-R nrPDB Length = 424 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 51/190 (26%), Positives = 83/190 (43%), Gaps = 24/190 (12%) Query: 96 SGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSK 155 SG E+ ++L I + ++D G YT S L+ ++ + RV+ E P + S Sbjct: 151 SGSEMKKFLSTLTIDGVTRSDQGLYTC-AASSGLMTKKNSTFVRVH-EKPFVAFGSGMES 208 Query: 156 PVEDKDAVAFTCEPETQDATYL--------WWVNNQSLPVSPRLQLSNGNRTLTLFNVTR 207 VE A E A YL W+ N +P+ + G+ LT+ V+ Sbjct: 209 LVE-----ATVGERVRIPAKYLGYPPPEIKWYKNG--IPLESNHTIKAGH-VLTIMEVSE 260 Query: 208 NDTASYKCETQNPVSARRSDSVILNVLYGP----DAPTISPLNTSYRSGENLNLSCHAAS 263 DT +Y NP+S + V+ V+Y P + ISP++ SY+ G L+C + Sbjct: 261 RDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVD-SYQYGTTQTLTCTVYA 319 Query: 264 NPPAQY-SWF 272 PP + W+ Sbjct: 320 IPPPHHIHWY 329 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 62/250 (24%), Positives = 94/250 (37%), Gaps = 40/250 (16%) Query: 407 VILNVLYGPDDPTISPSY-TYYRPGVNLSLSCHAAS--NPPAQYSWLIDGNIQQHTQ--- 460 +++ V Y D +SPS+ G L L+C A + N ++W + QH + Sbjct: 85 IVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVN 144 Query: 461 ----------------ELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPS 504 L I +T + GLYTC A +SG T E P + Sbjct: 145 RDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAA---SSGLMTKKNSTFVRVHEKPFVA 201 Query: 505 ISSNNSKPVEDKDAVAFTCEPEAQNTTY-----LWWVNGQSLPVSPRLQLSNGNRTLTLF 559 S VE V A+ Y W+ NG +P+ + G+ LT+ Sbjct: 202 FGSGMESLVEA--TVGERVRIPAKYLGYPPPEIKWYKNG--IPLESNHTIKAGH-VLTIM 256 Query: 560 NVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGP----DTPIISPPDSSYLSGANLNLSC 615 V+ D Y + N +S + V V+Y P + +ISP D SY G L+C Sbjct: 257 EVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVD-SYQYGTTQTLTC 315 Query: 616 HSASNPSPQY 625 + P P + Sbjct: 316 TVYAIPPPHH 325 Score = 38.1 bits (87), Expect = 0.014, Method: Compositional matrix adjust. Identities = 33/149 (22%), Positives = 62/149 (41%), Gaps = 9/149 (6%) Query: 182 NQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPT 241 N+ L ++ TLT+ VTR+D Y C + + ++ +S + V P Sbjct: 144 NRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKK-NSTFVRVHEKPFVAF 202 Query: 242 ISPLNTSYRS--GENLNLSCHAASNPPAQYSWFVNGTFQQSTQE------LFIPNITVNN 293 S + + + GE + + PP + W+ NG +S L I ++ + Sbjct: 203 GSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERD 262 Query: 294 SGSYTCQAHNSDTGLNRTTVTTITVYAEP 322 +G+YT N + ++ V ++ VY P Sbjct: 263 TGNYTVILTNPISKEKQSHVVSLVVYVPP 291 Score = 37.0 bits (84), Expect = 0.030, Method: Compositional matrix adjust. Identities = 33/128 (25%), Positives = 54/128 (42%), Gaps = 9/128 (7%) Query: 555 TLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLS--GANLN 612 TLT+ VTR+D Y C + + + + + V P S +S + G + Sbjct: 161 TLTIDGVTRSDQGLYTCAASSGL-MTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVR 219 Query: 613 LSCHSASNPSPQYSWRINGIPQQ--HT----QVLFIAKITPNNNGTYACFVSNLATGRNN 666 + P P+ W NGIP + HT VL I +++ + G Y ++N + Sbjct: 220 IPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQ 279 Query: 667 SIVKSITV 674 S V S+ V Sbjct: 280 SHVVSLVV 287 Score = 35.8 bits (81), Expect = 0.068, Method: Compositional matrix adjust. Identities = 45/180 (25%), Positives = 73/180 (40%), Gaps = 32/180 (17%) Query: 284 LFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVAL 343 L I +T ++ G YTC A S + + T + V+ KPF+ + E V Sbjct: 162 LTIDGVTRSDQGLYTCAA--SSGLMTKKNSTFVRVHE---KPFVAFGSGMESLVEATVGE 216 Query: 344 TCE----------PEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYEC 393 PEI+ W+ N L + ++ + LT++ V+ D G Y Sbjct: 217 RVRIPAKYLGYPPPEIK-----WYKNGIPLESNHTIKAGH---VLTIMEVSERDTGNYTV 268 Query: 394 GIQNKLSVDHSDPVILNVLYGP----DDPTISP--SYTYYRPGVNLSLSCHAASNPPAQY 447 + N +S + V+ V+Y P + ISP SY Y G +L+C + PP + Sbjct: 269 ILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQY---GTTQTLTCTVYAIPPPHH 325 Score = 29.3 bits (64), Expect = 6.6, Method: Compositional matrix adjust. Identities = 32/151 (21%), Positives = 57/151 (37%), Gaps = 21/151 (13%) Query: 360 NQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVD--------HSDPVILNV 411 N+ L ++ TLT+ VTR+D G Y C + L H P V Sbjct: 144 NRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPF---V 200 Query: 412 LYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDG------NIQQHTQELFIS 465 +G ++ + G + + PP + W +G + + L I Sbjct: 201 AFGSGMESLVEATV----GERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIM 256 Query: 466 NITEKNSGLYTCQANNSASGHSRTTVKTITV 496 ++E+++G YT N S ++ V ++ V Sbjct: 257 EVSERDTGNYTVILTNPISKEKQSHVVSLVV 287 >4FOM-A nrPDB Length = 308 Score = 45.4 bits (106), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 66/254 (25%), Positives = 101/254 (39%), Gaps = 29/254 (11%) Query: 268 QYSWFVNGTFQQST---------QELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITV 318 QY + V G +Q + + NI ++SG Y C+A G N + TT+TV Sbjct: 51 QYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLG-NAQSSTTVTV 109 Query: 319 YAEPPKPFITSNNSNPVEDEDAVALTCEPEIQN-TTYLWWVNNQSLPVSPRLQLSNDNRT 377 EP I +S + VA C ++ W + S N+ T Sbjct: 110 LVEPTVSLIKGPDSLIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETAT 169 Query: 378 LT---LLSVTRNDVGP-YECGIQN-KLSVDHSDPVILNVLYGPDDPTISPSYTYY--RPG 430 + L TR G C +++ L D IL++ Y P+ ++ R G Sbjct: 170 IISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKG 229 Query: 431 VNLSLSCHAASNPP---AQYSWLI----DGNIQQHTQELFISNITEKNSGLYTCQANNSA 483 VNL C+A +NPP + +S L DG + F+ +T SG+Y C+ NS Sbjct: 230 VNLK--CNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSL 287 Query: 484 SGHSRTTVKTITVS 497 R+ K I +S Sbjct: 288 G--QRSDQKVIYIS 299 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 50/223 (22%), Positives = 92/223 (41%), Gaps = 14/223 (6%) Query: 464 ISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTC 523 + NI +SG Y C+A G+++++ T+TV E I +S + VA C Sbjct: 78 LHNIGFSDSGKYICKAVTFPLGNAQSST-TVTVLVEPTVSLIKGPDSLIDGGNETVAAIC 136 Query: 524 -EPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTL----TLFNVTRNDARAYVCGIQN-SV 577 + ++ W S N T+ LF R C +++ ++ Sbjct: 137 IAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPAL 196 Query: 578 SANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYS-W-RI-----N 630 + LD+ Y P+ + + ++ +NL C++ +NP P S W R+ + Sbjct: 197 EKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPD 256 Query: 631 GIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSIT 673 G+ + F+ +T N +G Y C V+N R++ V I+ Sbjct: 257 GLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYIS 299 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 55/247 (22%), Positives = 95/247 (38%), Gaps = 22/247 (8%) Query: 95 YSGREIIYPN-----ASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSI 149 Y GR +++ N A++ + NI +D+G Y + L N +++ V E I Sbjct: 60 YQGR-VLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLI 118 Query: 150 SSNNSKPVEDKDAVAFTCEPET-QDATYLWWVNNQSLPVSPRLQLSNGNRTL----TLFN 204 +S + VA C T + ++ W + S N T+ LF Sbjct: 119 KGPDSLIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFP 178 Query: 205 VTRNDTASYKCETQNPVSARRSD-SVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAAS 263 C ++P + S IL++ Y P+ + + +NL C+A + Sbjct: 179 TRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADA 238 Query: 264 NPPAQYS-W------FVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTI 316 NPP S W + +G F+ +T N SG Y C+ NS L + + + Sbjct: 239 NPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNS---LGQRSDQKV 295 Query: 317 TVYAEPP 323 ++PP Sbjct: 296 IYISDPP 302 Score = 34.7 bits (78), Expect = 0.14, Method: Compositional matrix adjust. Identities = 33/124 (26%), Positives = 50/124 (40%), Gaps = 13/124 (10%) Query: 553 NRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLN 612 + T+TL N+ +D+ Y+C N T+ VL P +I PD S + G N Sbjct: 73 DATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPD-SLIDGGNET 131 Query: 613 LS--CHSAS-NPSPQYSWRINGIPQQHTQVLFIAKITPNNNGT----YACFVSNLATGRN 665 ++ C +A+ P W + + T F PN T Y F + A GR Sbjct: 132 VAAICIAATGKPVAHIDWEGDLGEMESTTTSF-----PNETATIISQYKLFPTRFARGRR 186 Query: 666 NSIV 669 + V Sbjct: 187 ITCV 190 >4MYW-B nrPDB Length = 331 Score = 43.1 bits (100), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 59/246 (23%), Positives = 95/246 (38%), Gaps = 27/246 (10%) Query: 272 FVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSN- 330 F +GT + S EL + G Y C+ TG NR + +TV A+P + Sbjct: 89 FTDGTIRLSRLEL-------EDEGVYICEFATFPTG-NRESQLNLTVMAKPTNWIEGTQA 140 Query: 331 --NSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDV 388 + +D+ + TC + + + ++ N N T+T++S R + Sbjct: 141 VLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVIS--RYRL 198 Query: 389 GPYECGIQNKLSV-------DHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAAS 441 P Q L+ + + LNV Y P+ +Y +++ L+C A + Sbjct: 199 VPSREAHQQSLACIVNYHMDRFKESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADA 258 Query: 442 NPPA-QYSW------LIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTI 494 NPPA +Y W L G Q+ F I +G Y C+A N S I Sbjct: 259 NPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNI 318 Query: 495 TVSAEL 500 T +A L Sbjct: 319 TEAAAL 324 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 27/103 (26%), Positives = 49/103 (47%), Gaps = 7/103 (6%) Query: 582 SDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASN-PSPQYSWRI------NGIPQ 634 + +TL+V Y P+ I + YL ++ L+C + +N P+ +Y W G+ Sbjct: 221 KESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEA 280 Query: 635 QHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSAS 677 Q+ + F I + GTY C +N R+ + +IT +A+ Sbjct: 281 QNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEAAA 323 Score = 38.5 bits (88), Expect = 0.010, Method: Compositional matrix adjust. Identities = 28/88 (31%), Positives = 46/88 (52%), Gaps = 9/88 (10%) Query: 224 RRSDSVILNVLYGPDAPTISPLNTS-YRSGENLNLSCHAASNPPA-QYSW-FVNGTFQQS 280 R +S+ LNV Y P+ TI + + Y ++ L+C A +NPPA +Y W +NG+ + Sbjct: 219 RFKESLTLNVQYEPEV-TIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKG 277 Query: 281 TQE-----LFIPNITVNNSGSYTCQAHN 303 + F I + +G+Y C+A N Sbjct: 278 VEAQNRTLFFKGPINYSLAGTYICEATN 305 >3S97-C nrPDB Length = 201 Score = 41.6 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 43/190 (22%), Positives = 75/190 (39%), Gaps = 26/190 (13%) Query: 134 ATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQ---DATYLWWVNNQSLPVS-- 188 +G +P +P + V++ + C+P D +Y W +N + ++ Sbjct: 3 GSGYLDPFPPEERPEVR------VKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMD 56 Query: 189 PRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPD---APTISPL 245 R +S N L + NV +D +Y C +P + S + ++ P+ P + + Sbjct: 57 KRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADI 116 Query: 246 NTSYRS-----GENLNLSCHAASNPPAQYSWFVNGTFQQSTQE-------LFIPNITVNN 293 ++ G+N+ L C A NP W ST E L I NI + + Sbjct: 117 VVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLED 176 Query: 294 SGSYTCQAHN 303 G Y C+A N Sbjct: 177 EGIYECEAEN 186 Score = 36.6 bits (83), Expect = 0.043, Method: Composition-based stats. Identities = 43/178 (24%), Positives = 61/178 (34%), Gaps = 40/178 (22%) Query: 513 VEDKDAVAFTCEPE---AQNTTYLWWVNGQSLPV----SPRLQLSNGNRTLTLFNVTRND 565 V++ + C+P + +Y W +N PV R +S N L + NV +D Sbjct: 20 VKEGKGMVLLCDPPYHFPDDLSYRWLLN--EFPVFITMDKRRFVSQTNGNLYIANVEASD 77 Query: 566 ARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPP----------------DSSYLSGA 609 Y C + S P ++ P+I P D L G Sbjct: 78 KGNYSCFV--------SSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQ 129 Query: 610 NLNLSCHSASNPSPQYSWRINGIPQQHT-------QVLFIAKITPNNNGTYACFVSNL 660 N+ L C + NP P WR P T VL I I + G Y C N+ Sbjct: 130 NVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENI 187 Score = 36.2 bits (82), Expect = 0.055, Method: Composition-based stats. Identities = 40/175 (22%), Positives = 64/175 (36%), Gaps = 36/175 (20%) Query: 335 VEDEDAVALTCEPEIQ---NTTYLWWVNNQSLPVS--PRLQLSNDNRTLTLLSVTRNDVG 389 V++ + L C+P + +Y W +N + ++ R +S N L + +V +D G Sbjct: 20 VKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKG 79 Query: 390 PYECGIQNKLSVDHSDPVILNVLYG----------------PDDPTISPSYTYYRPGVNL 433 Y C + S P I ++ P D + Y G N+ Sbjct: 80 NYSCFV--------SSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNV 131 Query: 434 SLSCHAASNPPAQYSWL-------IDGNIQQHTQELFISNITEKNSGLYTCQANN 481 +L C A NP W I L I NI ++ G+Y C+A N Sbjct: 132 TLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAEN 186 >5VI4-B nrPDB Length = 309 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 53/231 (22%), Positives = 91/231 (39%), Gaps = 33/231 (14%) Query: 159 DKDAVAFTCEPETQDATY--LWWVN--NQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYK 214 + +A+ C P+ +TY W+ + N+S+P R ++ L D+ Y Sbjct: 11 ENEALIVRC-PQRGRSTYPVEWYYSDTNESIPTQKRNRIFVSRDRLKFLPARVEDSGIYA 69 Query: 215 CETQNPVSARRSDSVILNVLYGPDAPTIS-----PLNTSYRSGENLNLSCHAAS--NPPA 267 C ++P + + LNV P+ + +T S +N ++C N A Sbjct: 70 CVIRSP---NLNKTGYLNVTIHKKPPSCNIPDYLMYSTVRGSDKNFKITCPTIDLYNWTA 126 Query: 268 QYSWFVNGT------FQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAE 321 WF N F+ LFI N+T ++ G YTCQ +++ G N T + E Sbjct: 127 PVQWFKNCKALQEPRFRAHRSYLFIDNVTHDDEGDYTCQFTHAENGTNYIVTATRSFTVE 186 Query: 322 PPK----PFITS---NNSNPVEDEDAVALTCEPEIQNTTY-----LWWVNN 360 P IT+ N++ VE ++ C ++ LW +N Sbjct: 187 EKGFSMFPVITNPPYNHTMEVEIGKPASIACSACFGKGSHFLADVLWQINK 237 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 45/180 (25%), Positives = 74/180 (41%), Gaps = 21/180 (11%) Query: 337 DEDAVALTCEPEIQNTTY--LWWVN--NQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYE 392 + +A+ + C P+ +TY W+ + N+S+P R ++ L L D G Y Sbjct: 11 ENEALIVRC-PQRGRSTYPVEWYYSDTNESIPTQKRNRIFVSRDRLKFLPARVEDSGIYA 69 Query: 393 CGIQNKLSVDHSDPVILNVLYGPDDPTIS-PSYTYYR----PGVNLSLSCHAAS--NPPA 445 C I+ S + + LNV P+ + P Y Y N ++C N A Sbjct: 70 CVIR---SPNLNKTGYLNVTIHKKPPSCNIPDYLMYSTVRGSDKNFKITCPTIDLYNWTA 126 Query: 446 QYSW------LIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAE 499 W L + + H LFI N+T + G YTCQ ++ +G + T + + E Sbjct: 127 PVQWFKNCKALQEPRFRAHRSYLFIDNVTHDDEGDYTCQFTHAENGTNYIVTATRSFTVE 186 Score = 32.0 bits (71), Expect = 1.0, Method: Compositional matrix adjust. Identities = 43/186 (23%), Positives = 69/186 (37%), Gaps = 25/186 (13%) Query: 515 DKDAVAFTCEPEAQNTTYLWWV---NGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVC 571 + +A+ C ++T + W +S+P R ++ L D+ Y C Sbjct: 11 ENEALIVRCPQRGRSTYPVEWYYSDTNESIPTQKRNRIFVSRDRLKFLPARVEDSGIYAC 70 Query: 572 GIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYL-------SGANLNLSCHSAS--NPS 622 I+ S N + L+V P + PD YL S N ++C + N + Sbjct: 71 VIR---SPNLNKTGYLNVTIHKKPPSCNIPD--YLMYSTVRGSDKNFKITCPTIDLYNWT 125 Query: 623 PQYSWRINGIPQQ------HTQVLFIAKITPNNNGTYACFVSNLATGRNNSI--VKSITV 674 W N Q H LFI +T ++ G Y C ++ G N + +S TV Sbjct: 126 APVQWFKNCKALQEPRFRAHRSYLFIDNVTHDDEGDYTCQFTHAENGTNYIVTATRSFTV 185 Query: 675 SASGTS 680 G S Sbjct: 186 EEKGFS 191 >5OYJ-C nrPDB Length = 234 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 28/99 (28%), Positives = 47/99 (47%), Gaps = 8/99 (8%) Query: 179 WVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGP- 237 W N +P+ + G+ LT+ V+ DT +Y NP+S + V+ V+Y P Sbjct: 43 WYKN-GIPLESNHTIKAGH-VLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPP 100 Query: 238 ---DAPTISPLNTSYRSGENLNLSCHAASNPPAQY-SWF 272 + ISP++ SY+ G L+C + PP + W+ Sbjct: 101 QIGEKSLISPVD-SYQYGTTQTLTCTVYAIPPPHHIHWY 138 Score = 35.0 bits (79), Expect = 0.098, Method: Compositional matrix adjust. Identities = 27/96 (28%), Positives = 43/96 (44%), Gaps = 8/96 (8%) Query: 534 WWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGP 593 W+ NG +P+ + G+ LT+ V+ D Y + N +S + V V+Y P Sbjct: 43 WYKNG--IPLESNHTIKAGH-VLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVP 99 Query: 594 ----DTPIISPPDSSYLSGANLNLSCHSASNPSPQY 625 + +ISP D SY G L+C + P P + Sbjct: 100 PQIGEKSLISPVD-SYQYGTTQTLTCTVYAIPPPHH 134 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 20/73 (27%), Positives = 32/73 (43%), Gaps = 6/73 (8%) Query: 608 GANLNLSCHSASNPSPQYSWRINGIPQQ--HT----QVLFIAKITPNNNGTYACFVSNLA 661 G + + P P+ W NGIP + HT VL I +++ + G Y ++N Sbjct: 24 GERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPI 83 Query: 662 TGRNNSIVKSITV 674 + S V S+ V Sbjct: 84 SKEKQSHVVSLVV 96 Score = 31.2 bits (69), Expect = 1.7, Method: Compositional matrix adjust. Identities = 23/78 (29%), Positives = 36/78 (46%), Gaps = 9/78 (11%) Query: 376 RTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGP----DDPTISP--SYTYYRP 429 LT++ V+ D G Y + N +S + V+ V+Y P + ISP SY Y Sbjct: 60 HVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQY--- 116 Query: 430 GVNLSLSCHAASNPPAQY 447 G +L+C + PP + Sbjct: 117 GTTQTLTCTVYAIPPPHH 134 >3BFO-A nrPDB Length = 91 Score = 40.0 bits (92), Expect = 0.004, Method: Compositional matrix adjust. Identities = 20/77 (25%), Positives = 35/77 (45%), Gaps = 2/77 (2%) Query: 598 ISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQH--TQVLFIAKITPNNNGTYAC 655 + P + G+ L L C + +P P Y W N +P H ++ + + + GTY C Sbjct: 8 VEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWC 67 Query: 656 FVSNLATGRNNSIVKSI 672 V N +++ V+ I Sbjct: 68 HVYNDRDSQDSKKVEII 84 Score = 38.5 bits (88), Expect = 0.009, Method: Compositional matrix adjust. Identities = 20/77 (25%), Positives = 33/77 (42%), Gaps = 2/77 (2%) Query: 242 ISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGT-FQQSTQELF-IPNITVNNSGSYTC 299 + P + G L L C A +P Y WF N T++L+ +P + + + G+Y C Sbjct: 8 VEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWC 67 Query: 300 QAHNSDTGLNRTTVTTI 316 +N + V I Sbjct: 68 HVYNDRDSQDSKKVEII 84 Score = 30.0 bits (66), Expect = 4.0, Method: Compositional matrix adjust. Identities = 18/77 (23%), Positives = 31/77 (40%), Gaps = 2/77 (2%) Query: 420 ISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGN-IQQHTQELF-ISNITEKNSGLYTC 477 + P+ PG L L C A +P Y W + + T++L+ + + ++ G Y C Sbjct: 8 VEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWC 67 Query: 478 QANNSASGHSRTTVKTI 494 N V+ I Sbjct: 68 HVYNDRDSQDSKKVEII 84 >5IMK-A nrPDB Length = 220 Score = 38.5 bits (88), Expect = 0.010, Method: Compositional matrix adjust. Identities = 37/132 (28%), Positives = 55/132 (41%), Gaps = 19/132 (14%) Query: 190 RLQLSN---GNRTLTLFNVTRNDTASYKCET--QNPVSAR--RSDSVILNV----LYGPD 238 RL +S+ G+ +L L + +D + Y CE Q P + R L V + P Sbjct: 73 RLHVSHKVPGDVSLQLSTLEMDDRSHYTCEVTWQTPDGNQVVRDKITELRVQKLSVSKPT 132 Query: 239 APTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQS-------TQELFIPNITV 291 T S + G ++L C A +PP Y W+ T Q + LF P + + Sbjct: 133 VTTGSGYGFTVPQGMRISLQCQARGSPPISYIWYKQQTNNQEPIKVATLSTLLFKPAV-I 191 Query: 292 NNSGSYTCQAHN 303 +SGSY C A Sbjct: 192 ADSGSYFCTAKG 203 Score = 28.9 bits (63), Expect = 9.1, Method: Compositional matrix adjust. Identities = 22/86 (25%), Positives = 33/86 (38%), Gaps = 7/86 (8%) Query: 419 TISPSYTYYRP-GVNLSLSCHAASNPPAQYSWLIDG-NIQQHTQELFISNITEK-----N 471 T Y + P G+ +SL C A +PP Y W N Q+ + +S + K + Sbjct: 134 TTGSGYGFTVPQGMRISLQCQARGSPPISYIWYKQQTNNQEPIKVATLSTLLFKPAVIAD 193 Query: 472 SGLYTCQANNSASGHSRTTVKTITVS 497 SG Y C A + + V Sbjct: 194 SGSYFCTAKGQVGSEQHSDIVKFVVK 219 >2L7J-A nrPDB Length = 95 Score = 38.5 bits (88), Expect = 0.010, Method: Compositional matrix adjust. Identities = 26/94 (27%), Positives = 44/94 (46%), Gaps = 7/94 (7%) Query: 587 LDVLYGPDTPIISPPDSSYLSGANLNLSCHSASN-PSPQYSWRI------NGIPQQHTQV 639 L+V Y P+ I + YL ++ L+C + +N P+ +Y W G+ Q+ + Sbjct: 1 LNVQYEPEVTIEGFDGNWYLQRTDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTL 60 Query: 640 LFIAKITPNNNGTYACFVSNLATGRNNSIVKSIT 673 F IT + GTY C +N R+ + +IT Sbjct: 61 FFRGPITYSLAGTYICEATNPIGTRSGQVEVNIT 94 Score = 36.6 bits (83), Expect = 0.037, Method: Compositional matrix adjust. Identities = 26/80 (32%), Positives = 36/80 (45%), Gaps = 7/80 (8%) Query: 409 LNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPA-QYSW------LIDGNIQQHTQE 461 LNV Y P+ +Y ++ L+C A +NPPA +Y W L G Q+ Sbjct: 1 LNVQYEPEVTIEGFDGNWYLQRTDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTL 60 Query: 462 LFISNITEKNSGLYTCQANN 481 F IT +G Y C+A N Sbjct: 61 FFRGPITYSLAGTYICEATN 80 Score = 36.2 bits (82), Expect = 0.052, Method: Compositional matrix adjust. Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 7/80 (8%) Query: 231 LNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPA-QYSW-FVNGTFQQSTQE----- 283 LNV Y P+ Y ++ L+C A +NPPA +Y W +NG+ + + Sbjct: 1 LNVQYEPEVTIEGFDGNWYLQRTDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTL 60 Query: 284 LFIPNITVNNSGSYTCQAHN 303 F IT + +G+Y C+A N Sbjct: 61 FFRGPITYSLAGTYICEATN 80 Score = 29.6 bits (65), Expect = 5.2, Method: Compositional matrix adjust. Identities = 26/94 (27%), Positives = 39/94 (41%), Gaps = 8/94 (8%) Query: 145 PKPSISSNNSKPVEDKDAVAFTCEPETQ--DATYLWWVNNQSLPVSPRLQLSNGNRTLTL 202 P+ +I + + V TC+ + Y W N SLP Q NRTL Sbjct: 7 PEVTIEGFDGNWYLQRTDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQ----NRTLFF 62 Query: 203 FN-VTRNDTASYKCETQNPVSARRSDSVILNVLY 235 +T + +Y CE NP+ RS V +N+ + Sbjct: 63 RGPITYSLAGTYICEATNPIGT-RSGQVEVNITH 95 >3O3U-N nrPDB Length = 581 Score = 38.1 bits (87), Expect = 0.014, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 43/109 (39%), Gaps = 22/109 (20%) Query: 246 NTSYRSGENLNLSCHAA-SNPPAQYSWFVNGTFQQSTQ--------------------EL 284 N + R GE L L C A PP + W +N ++ + L Sbjct: 375 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSL 434 Query: 285 FIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSN 333 F+P + + + G + CQA N + G + + VY P KP I + S Sbjct: 435 FLPAVGIQDEGIFRCQAMNRN-GKETKSNYRVRVYQIPGKPEIVDSASE 482 >2XY2-A nrPDB Length = 189 Score = 37.7 bits (86), Expect = 0.019, Method: Composition-based stats. Identities = 29/117 (24%), Positives = 50/117 (42%), Gaps = 16/117 (13%) Query: 165 FTC----EPETQDATYLWWVNNQSLPVSPRLQL---SNGNRT-LTLFNVTRNDTASYKCE 216 FTC EPE+ D W N Q + ++ G R+ LT++N D Y+C+ Sbjct: 22 FTCTAIGEPESID-----WYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQ 76 Query: 217 TQNPVSARRSDSVILNVLYGPD-APTISPLNTSYRSGENLNLSCHAASNPPAQYSWF 272 + + +V+L + +SP ++ GE+ + C +S+P SW Sbjct: 77 ATDAKGQTQEATVVLEIYQKLTFREVVSP--QEFKQGEDAEVVCRVSSSPAPAVSWL 131 Score = 35.4 bits (80), Expect = 0.082, Method: Composition-based stats. Identities = 38/144 (26%), Positives = 65/144 (45%), Gaps = 26/144 (18%) Query: 494 ITVSAELPKPSISSNNSKPVEDKDAVAFTC----EPEAQNTTYLWWVN--GQSLPVSPRL 547 + V+ L K +S SK FTC EPE+ + W N G+ + + R+ Sbjct: 3 LQVTISLSKVELSVGESK--------FFTCTAIGEPESID-----WYNPQGEKIISTQRV 49 Query: 548 QLSN-GNRT-LTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDT--PIISPPDS 603 + G R+ LT++N DA Y C ++ + V L++ Y T ++SP + Sbjct: 50 VVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEI-YQKLTFREVVSPQE- 107 Query: 604 SYLSGANLNLSCHSASNPSPQYSW 627 + G + + C +S+P+P SW Sbjct: 108 -FKQGEDAEVVCRVSSSPAPAVSW 130 >4BSJ-A nrPDB Length = 232 Score = 37.0 bits (84), Expect = 0.032, Method: Compositional matrix adjust. Identities = 25/89 (28%), Positives = 38/89 (42%), Gaps = 10/89 (11%) Query: 433 LSLSCHAASNPPAQYSWLIDGNI---QQHTQELFISNITEKNSGLYTCQANNSASGHSRT 489 + L A+ PP ++ W DG + L + +TE ++G YT NSA+G R Sbjct: 25 VKLPVKLAAYPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRN 84 Query: 490 TVKTITV-------SAELPKPSISSNNSK 511 + V E PSI S +S+ Sbjct: 85 ISLELVVNVPPQIHEKEASSPSIYSRHSR 113 Score = 36.2 bits (82), Expect = 0.050, Method: Compositional matrix adjust. Identities = 21/82 (25%), Positives = 37/82 (45%), Gaps = 3/82 (3%) Query: 244 PLNTSYRSGENLNLSCHAASNPPAQYSWFVNG---TFQQSTQELFIPNITVNNSGSYTCQ 300 P+ + E + L A+ PP ++ W+ +G + + S L + +T ++G+YT Sbjct: 14 PILEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLA 73 Query: 301 AHNSDTGLNRTTVTTITVYAEP 322 NS GL R + V P Sbjct: 74 LWNSAAGLRRNISLELVVNVPP 95 >5B22-A nrPDB Length = 211 Score = 35.8 bits (81), Expect = 0.060, Method: Compositional matrix adjust. Identities = 33/124 (26%), Positives = 51/124 (41%), Gaps = 13/124 (10%) Query: 553 NRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLN 612 + T+TL N+ +D+ Y+C N T+ VL P +I PD S + G N Sbjct: 73 DATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPD-SLIDGGNET 131 Query: 613 LS--CHSAS-NPSPQYSWRINGIPQQHTQVLFIAKITPNNNGT----YACFVSNLATGRN 665 ++ C +A+ P Q W + + + F PN T Y F + A GR Sbjct: 132 VAAVCVAATGKPVAQIDWEGDLGEMESSTTSF-----PNETATIVSQYKLFPTRFARGRR 186 Query: 666 NSIV 669 + V Sbjct: 187 ITCV 190 Score = 30.8 bits (68), Expect = 2.1, Method: Compositional matrix adjust. Identities = 25/87 (28%), Positives = 36/87 (41%), Gaps = 10/87 (11%) Query: 268 QYSWFVNGTFQQST---------QELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITV 318 QY + V G +Q + + NI ++SG Y C+A G N + TT+TV Sbjct: 51 QYGFSVQGDYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLG-NAQSSTTVTV 109 Query: 319 YAEPPKPFITSNNSNPVEDEDAVALTC 345 EP I +S + VA C Sbjct: 110 LVEPTVSLIKGPDSLIDGGNETVAAVC 136 >3O2D-A nrPDB Length = 188 Score = 35.0 bits (79), Expect = 0.12, Method: Compositional matrix adjust. Identities = 34/162 (20%), Positives = 63/162 (38%), Gaps = 31/162 (19%) Query: 517 DAVAFTCEPEAQNTTYLWWVNGQSLPV--------------------SPRLQLSNGNRTL 556 D V TC + + W N + + S R GN L Sbjct: 10 DTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPL 69 Query: 557 TLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCH 616 + N+ D+ Y+C ++ ++ + V L +++G + + D+ L G +L L+ Sbjct: 70 IIKNLKIEDSDTYICEVE-----DQKEEVQL-LVFG----LTANSDTHLLQGQSLTLTLE 119 Query: 617 SASNPSPQYSWRI-NGIPQQHTQVLFIAKITPNNNGTYACFV 657 S SP R G Q + L ++++ ++GT+ C V Sbjct: 120 SPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTV 161 >1WIO-A nrPDB Length = 363 Score = 35.0 bits (79), Expect = 0.12, Method: Compositional matrix adjust. Identities = 34/162 (20%), Positives = 63/162 (38%), Gaps = 31/162 (19%) Query: 517 DAVAFTCEPEAQNTTYLWWVNGQSLPV--------------------SPRLQLSNGNRTL 556 D V TC + + W N + + S R GN L Sbjct: 10 DTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPL 69 Query: 557 TLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCH 616 + N+ D+ Y+C ++ ++ + V L +++G + + D+ L G +L L+ Sbjct: 70 IIKNLKIEDSDTYICEVE-----DQKEEVQL-LVFG----LTANSDTHLLQGQSLTLTLE 119 Query: 617 SASNPSPQYSWRI-NGIPQQHTQVLFIAKITPNNNGTYACFV 657 S SP R G Q + L ++++ ++GT+ C V Sbjct: 120 SPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTV 161 >3O4O-B nrPDB Length = 339 Score = 35.0 bits (79), Expect = 0.13, Method: Compositional matrix adjust. Identities = 39/174 (22%), Positives = 70/174 (40%), Gaps = 29/174 (16%) Query: 531 TYLWWVNGQSL----PVSPRL---QLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRS- 582 T +W+ Q P++ RL ++S L ND Y C ++N+ ++ Sbjct: 50 TLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVA 109 Query: 583 ---DPVTLDVLYGPDTPIISPPDSSYLSGANLNLSC-----HSASNPSPQYSWRI----- 629 + V D + ++P+ P Y+ ++C + S+ P +W + Sbjct: 110 FPLEVVQKDSCF--NSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKI 167 Query: 630 ----NGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGT 679 N IP+ IA I+ NNG Y C V+ GR + +++TV G+ Sbjct: 168 QNFNNVIPEGMNLSFLIALIS--NNGNYTCVVTYPENGRTFHLTRTLTVKVVGS 219 >4Q6I-C nrPDB Length = 208 Score = 34.7 bits (78), Expect = 0.13, Method: Compositional matrix adjust. Identities = 34/162 (20%), Positives = 63/162 (38%), Gaps = 31/162 (19%) Query: 517 DAVAFTCEPEAQNTTYLWWVNGQSLPV--------------------SPRLQLSNGNRTL 556 D V TC + + W N + + S R GN L Sbjct: 35 DTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPL 94 Query: 557 TLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCH 616 + N+ D+ Y+C ++ ++ + V L +++G + + D+ L G +L L+ Sbjct: 95 IIKNLKIEDSDTYICEVE-----DQKEEVQL-LVFG----LTANSDTHLLQGQSLTLTLE 144 Query: 617 SASNPSPQYSWRI-NGIPQQHTQVLFIAKITPNNNGTYACFV 657 S SP R G Q + L ++++ ++GT+ C V Sbjct: 145 SPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTV 186 >4BFI-B nrPDB Length = 211 Score = 34.7 bits (78), Expect = 0.17, Method: Compositional matrix adjust. Identities = 29/100 (29%), Positives = 45/100 (45%), Gaps = 6/100 (6%) Query: 192 QLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRS 251 +L N ++T +N T D Y C S + S + L + P I L+ +Y Sbjct: 68 ELGLWNSSITFWNTTLEDEGCYMCLFNTFGSQKVSGTACLTLYVQP----IVHLHYNYFE 123 Query: 252 GENLNLSCHAASNPPAQYSWFVNGT-FQQSTQELFIPNIT 290 ++LN++C A + P SW GT + ST+ F N T Sbjct: 124 -DHLNITCSATARPAPAISWKGTGTGIENSTESHFHSNGT 162 Score = 32.3 bits (72), Expect = 0.72, Method: Compositional matrix adjust. Identities = 22/84 (26%), Positives = 36/84 (42%), Gaps = 5/84 (5%) Query: 548 QLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLS 607 +L N ++T +N T D Y+C S S L + P I +Y Sbjct: 68 ELGLWNSSITFWNTTLEDEGCYMCLFNTFGSQKVSGTACLTLYVQP----IVHLHYNYFE 123 Query: 608 GANLNLSCHSASNPSPQYSWRING 631 +LN++C + + P+P SW+ G Sbjct: 124 D-HLNITCSATARPAPAISWKGTG 146 >6FEY-A nrPDB Length = 242 Score = 34.3 bits (77), Expect = 0.20, Method: Compositional matrix adjust. Identities = 20/61 (32%), Positives = 29/61 (47%), Gaps = 9/61 (14%) Query: 430 GVNLSLSCHAASNPPAQYSWLIDGN---IQQHTQ------ELFISNITEKNSGLYTCQAN 480 G N+ L C + P A+ +WL + N +Q H +L IS I ++ G Y C A Sbjct: 163 GSNIQLPCRVHARPRAEITWLNNENKEIVQGHRHRVLANGDLLISEIKWEDMGNYKCIAR 222 Query: 481 N 481 N Sbjct: 223 N 223 Score = 32.3 bits (72), Expect = 0.72, Method: Compositional matrix adjust. Identities = 43/179 (24%), Positives = 65/179 (36%), Gaps = 34/179 (18%) Query: 515 DKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGN------------RTLTLFNVT 562 D + CE + WV G LP S L + R+ + + Sbjct: 47 DGATIEIVCEMMGSQVPSIQWVVGH-LPRSELDDLDSNQVAEEAPSAIVRVRSSHIIDHV 105 Query: 563 RNDARAYVC-GIQNS--------VSANRSDPVTLDVLY-GPDTPIISPPDSSYLS--GAN 610 ++AR Y C G S V RS +T + Y G P I + ++L G+N Sbjct: 106 LSEARTYTCVGRTGSKTIYASTVVHPPRSSRLTPEKTYPGAQKPRIIYTEKTHLDLMGSN 165 Query: 611 LNLSCHSASNPSPQYSWRIN---GIPQQHTQV------LFIAKITPNNNGTYACFVSNL 660 + L C + P + +W N I Q H L I++I + G Y C N+ Sbjct: 166 IQLPCRVHARPRAEITWLNNENKEIVQGHRHRVLANGDLLISEIKWEDMGNYKCIARNV 224 >3MJ9-A nrPDB Length = 268 Score = 32.7 bits (73), Expect = 0.60, Method: Compositional matrix adjust. Identities = 54/244 (22%), Positives = 102/244 (41%), Gaps = 40/244 (16%) Query: 36 LTIESTPFNVAEGKEVLL---LVHNLPQHLFGYSW-YKGERVDGNRQIIGYVIGTQQATP 91 LT+ S V G+ VL+ + +H+ W + ++ D + ++ Y + + P Sbjct: 8 LTVSSPQLRVHVGESVLMGCVVQRTEEKHVDRVDWLFSKDKDDASEYVLFYY--SNLSVP 65 Query: 92 GPAYSGR-----EIIYPNASLLIQNIIQNDTGFYTLHV-IKSDLVNEEATGQFRVYPELP 145 + R + + + SLL+Q++ + D G YT + +K++ + + + V PE P Sbjct: 66 TGRFQNRSHLVGDTFHNDGSLLLQDVQKADEGIYTCEIRLKNESMVMKKPVELWVLPEEP 125 Query: 146 KP-------------SISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNN------QSL- 185 + SI S K V K F+ T++ T L + +N QSL Sbjct: 126 RDLRVRVGDTTQMRCSIQSTEEKRVT-KVNWMFSSGSHTEEETVLSYDSNMRSGKFQSLG 184 Query: 186 ----PVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ-NPVSARRSDSVILNVLYGPDAP 240 V +S + ++ L V +D Y C + +R+ +++L+V+ Sbjct: 185 RFRNRVDLTGDISRNDGSIKLQTVKESDQGIYTCSIYVGKLESRK--TIVLHVVQDEFQR 242 Query: 241 TISP 244 TISP Sbjct: 243 TISP 246 >4KC3-B nrPDB Length = 309 Score = 32.3 bits (72), Expect = 0.66, Method: Compositional matrix adjust. Identities = 46/214 (21%), Positives = 76/214 (35%), Gaps = 25/214 (11%) Query: 182 NQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSAR--RSDSVILNVLYGPDA 239 N+S+P R ++ + L D+ Y C ++P R ++ I + Sbjct: 36 NKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNV 95 Query: 240 PTISPLNTSYRSGENLNLSCHAAS--NPPAQYSWFVNGTFQQSTQE------LFIPNITV 291 P +T S +N + C N A WF N Q ++ L I N+ Sbjct: 96 PDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMT 155 Query: 292 NNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFI--------TSNNSNPVEDEDAVAL 343 ++G YTC+ +++ G N + T + + + F N VE L Sbjct: 156 EDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANL 215 Query: 344 TCEPEIQNTT-----YLWWVNNQSLP--VSPRLQ 370 TC T LW +N + PR+Q Sbjct: 216 TCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQ 249 Score = 31.6 bits (70), Expect = 1.2, Method: Compositional matrix adjust. Identities = 51/220 (23%), Positives = 83/220 (37%), Gaps = 29/220 (13%) Query: 360 NQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPT 419 N+S+P R ++ + L L D G Y C +++ + + + + + D Sbjct: 36 NKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSP-TFNRTGYANVTIYKKQSDCN 94 Query: 420 ISPSYTYYR----PGVNLSLSCHAAS--NPPAQYSWLIDGNIQQ------HTQELFISNI 467 + P Y Y N + C N A W + Q H L I N+ Sbjct: 95 V-PDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNV 153 Query: 468 TEKNSGLYTCQ--ANNSASGHSRTTVKTITVSAELP---KPSISS---NNSKPVEDKDAV 519 +++G YTC+ N + + +S T ++ TV E P I + N K VE Sbjct: 154 MTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNA 213 Query: 520 AFTCEP-EAQNTTY----LWWVNGQSLP--VSPRLQLSNG 552 TC + T + LW +NG + PR+Q G Sbjct: 214 NLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEG 253 >1TLK-A nrPDB Length = 154 Score = 31.6 bits (70), Expect = 1.3, Method: Composition-based stats. Identities = 23/83 (27%), Positives = 37/83 (44%), Gaps = 9/83 (10%) Query: 146 KPSISSNNSKPVEDKDAVA-----FTCEPET-QDATYLWWVNNQSLPVSPRLQL---SNG 196 KP + +K + D D V F C+ E D +W+ ++ + S Q+ G Sbjct: 37 KPHVKPYFTKTILDMDVVEGSAARFDCKVEGYPDPEVMWFKDDNPVKESRHFQIDYDEEG 96 Query: 197 NRTLTLFNVTRNDTASYKCETQN 219 N +LT+ V +D A Y C+ N Sbjct: 97 NCSLTISEVCGDDDAKYTCKAVN 119 >1OLZ-A nrPDB Length = 663 Score = 31.2 bits (69), Expect = 1.5, Method: Compositional matrix adjust. Identities = 24/100 (24%), Positives = 41/100 (41%), Gaps = 5/100 (5%) Query: 132 EEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPV-SPR 190 +E +G V P+ K S + K C ++ A W N L SP+ Sbjct: 523 QEMSGDASVCPDKSKGSYRQHFFK---HGGTAELKCSQKSNLARVFWKFQNGVLKAESPK 579 Query: 191 LQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVI 230 L G + L +FN++ D+ Y+C ++ V + V+ Sbjct: 580 YGLM-GRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVV 618 Score = 28.9 bits (63), Expect = 8.2, Method: Compositional matrix adjust. Identities = 23/98 (23%), Positives = 39/98 (39%), Gaps = 3/98 (3%) Query: 476 TCQANNSASGHSRTTVKTITVSAEL-PKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLW 534 TC A + SR ++ ++ A + P S S + C ++ W Sbjct: 507 TCVALHQTESPSRGLIQEMSGDASVCPDKSKGSYRQHFFKHGGTAELKCSQKSNLARVFW 566 Query: 535 -WVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVC 571 + NG SP+ L G + L +FN++ D+ Y C Sbjct: 567 KFQNGVLKAESPKYGLM-GRKNLLIFNLSEGDSGVYQC 603 >3NVQ-A nrPDB Length = 590 Score = 31.2 bits (69), Expect = 1.7, Method: Compositional matrix adjust. Identities = 22/73 (30%), Positives = 33/73 (45%), Gaps = 16/73 (21%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQE--------LFISNITEK 470 +++P+ YY LSC S A YSW N++Q + LFI N+T + Sbjct: 511 SLAPNSRYY-------LSCPMESRH-ATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQ 562 Query: 471 NSGLYTCQANNSA 483 G Y C+A + Sbjct: 563 QYGHYFCEAQEGS 575 >4BFE-A nrPDB Length = 221 Score = 31.2 bits (69), Expect = 1.8, Method: Compositional matrix adjust. Identities = 31/107 (28%), Positives = 46/107 (42%), Gaps = 12/107 (11%) Query: 587 LDVLYGPDTPIISPPDSSYLSGANLNLSCHS-ASNPSPQYSWRINGIPQQHTQVLFIAKI 645 L+ +Y D ++ PP+ +Y G N C + A P+ Q SW +G + K Sbjct: 113 LEKVY--DLQVLVPPEVTYFPGKNRTAVCEAMAGKPAAQISWTPDGD--------CVTKS 162 Query: 646 TPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSAGATVGIM 692 ++NGT S +NN V S VS S + LS + G M Sbjct: 163 ESHSNGTVT-VRSTCHWEQNNVSVVSCLVSHSTGNQSLSIELSQGTM 208 Score = 30.0 bits (66), Expect = 4.1, Method: Compositional matrix adjust. Identities = 16/36 (44%), Positives = 20/36 (55%), Gaps = 2/36 (5%) Query: 420 ISPSYTYYRPGVNLSLSCHA-ASNPPAQYSWLIDGN 454 + P TY+ PG N + C A A P AQ SW DG+ Sbjct: 123 VPPEVTYF-PGKNRTAVCEAMAGKPAAQISWTPDGD 157 >5T89-X nrPDB Length = 646 Score = 30.4 bits (67), Expect = 2.9, Method: Compositional matrix adjust. Identities = 22/75 (29%), Positives = 31/75 (41%), Gaps = 19/75 (25%) Query: 252 GENLNLSCHAASNPPAQYSWFV-----NGTFQQS--------------TQELFIPNITVN 292 GE+L LSC +W + N T S T L I N+++ Sbjct: 544 GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQ 603 Query: 293 NSGSYTCQAHNSDTG 307 +SG+Y C+A N TG Sbjct: 604 DSGTYACRARNVYTG 618 Score = 28.9 bits (63), Expect = 7.2, Method: Compositional matrix adjust. Identities = 28/118 (23%), Positives = 48/118 (40%), Gaps = 21/118 (17%) Query: 294 SGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCE------- 346 SG Y C A N + R IT + P F + P E ED + L+C Sbjct: 504 SGIYICIASNKVGTVGRNISFYIT---DVPNGFHVNLEKMPTEGED-LKLSCTVNKFLYR 559 Query: 347 -------PEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQN 397 + N T + ++ Q + ++ ++ + LT+++V+ D G Y C +N Sbjct: 560 DVTWILLRTVNNRTMHYSISKQKMAITKEHSITLN---LTIMNVSLQDSGTYACRARN 614 >1KOA-A nrPDB Length = 491 Score = 30.0 bits (66), Expect = 3.2, Method: Compositional matrix adjust. Identities = 21/94 (22%), Positives = 37/94 (39%), Gaps = 11/94 (11%) Query: 242 ISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNG-TFQQSTQ----------ELFIPNIT 290 + P T G++ N C ++ P +W + +QS + L I + Sbjct: 381 VKPYGTEVGEGQSANFYCRVIASSPPVVTWHKDDRELKQSVKYMKRYNGNDYGLTINRVK 440 Query: 291 VNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPK 324 ++ G YT +A NS +T ++EP K Sbjct: 441 GDDKGEYTVRAKNSYGTKEEIVFLNVTRHSEPLK 474 >1EPF-A nrPDB Length = 191 Score = 30.0 bits (66), Expect = 3.2, Method: Composition-based stats. Identities = 35/157 (22%), Positives = 61/157 (38%), Gaps = 25/157 (15%) Query: 66 SWY--KGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLH 123 SW+ GE++ N+Q I V ++ +L I N +D G Y Sbjct: 36 SWFSPNGEKLSPNQQRISVVWNDDDSS---------------TLTIYNANIDDAGIYKCV 80 Query: 124 VIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDK---DAVAFTCEPETQDATYLWWV 180 V D EAT +++ +L + N P E K DAV + T +W Sbjct: 81 VTAEDGTQSEATVNVKIFQKL----MFKNAPTPQEFKEGEDAVIVCDVVSSLPPTIIWKH 136 Query: 181 NNQSLPVSPRLQ-LSNGNRTLTLFNVTRNDTASYKCE 216 + + + ++ + N L + + + D +Y+CE Sbjct: 137 KGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 173 Score = 28.5 bits (62), Expect = 9.7, Method: Composition-based stats. Identities = 33/151 (21%), Positives = 60/151 (39%), Gaps = 29/151 (19%) Query: 357 WVNNQSLPVSPRLQL------SNDNRTLTLLSVTRNDVGPYEC------GIQNKLSVDHS 404 W + +SP Q +D+ TLT+ + +D G Y+C G Q++ +V+ Sbjct: 37 WFSPNGEKLSPNQQRISVVWNDDDSSTLTIYNANIDDAGIYKCVVTAEDGTQSEATVNVK 96 Query: 405 DPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGN---IQQHTQE 461 I L + PT ++ G + + C S+ P W G +++ + Sbjct: 97 ---IFQKLMFKNAPTPQE----FKEGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRF 149 Query: 462 LFISN-------ITEKNSGLYTCQANNSASG 485 + +SN I + + G Y C+ A G Sbjct: 150 IVLSNNYLQIRGIKKTDEGTYRCEGRILARG 180 >3EC1-A nrPDB Length = 369 Score = 30.0 bits (66), Expect = 3.4, Method: Compositional matrix adjust. Identities = 19/69 (27%), Positives = 32/69 (46%), Gaps = 6/69 (8%) Query: 543 VSPRLQLSNGNRTLTLFNVTRND-----ARAYVCGIQNSVSANRSDPVTLDVLYGPDT-P 596 + PR+ N +TL + R D R++VC + N ++ +R+ D LY Sbjct: 246 IHPRVYQLNEGQTLFFGGLARLDYIKGGRRSFVCYMANELTVHRTKLEKADSLYANQLGE 305 Query: 597 IISPPDSSY 605 ++SPP Y Sbjct: 306 LLSPPSKRY 314 >1VCA-A nrPDB Length = 202 Score = 29.6 bits (65), Expect = 5.3, Method: Composition-based stats. Identities = 23/106 (21%), Positives = 44/106 (41%), Gaps = 2/106 (1%) Query: 161 DAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNP 220 D+V+ TC ++ + W P++ ++ TLT+ V+ + SY C T Sbjct: 17 DSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLC-TATC 75 Query: 221 VSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPP 266 S + + + + P P I L+ +G+ + + C A P Sbjct: 76 ESRKLEKGIQVEIYSFPKDPEIH-LSGPLEAGKPITVKCSVADVYP 120 Score = 29.3 bits (64), Expect = 6.0, Method: Composition-based stats. Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 14/88 (15%) Query: 597 IISPPDSSYLS--GANLNLSCHSASNPSPQYSWR------ING--IPQQHTQVLFIAKIT 646 I + P+S YL+ G +++L+C + SP +SWR +NG + T L + ++ Sbjct: 3 IETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVS 62 Query: 647 PNNNGTYACFVSNLATGRNNSIVKSITV 674 N +Y C AT + + K I V Sbjct: 63 FGNEHSYLC----TATCESRKLEKGIQV 86 >3QS9-E nrPDB Length = 527 Score = 29.3 bits (64), Expect = 5.7, Method: Compositional matrix adjust. Identities = 41/174 (23%), Positives = 77/174 (44%), Gaps = 32/174 (18%) Query: 463 FISNITEKNSGLYTCQANNSASGH-SRTTVKTITVSAELPKPSISSNNSKPVEDKD---- 517 F+S++ ++G YTC S+S H S++ + TI + K I++ NS + D Sbjct: 293 FVSSVARNDTGYYTC----SSSKHPSQSALVTI-----VEKGFINATNSSEDYEIDQYEE 343 Query: 518 ---AVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQ 574 +V F P+ + T W + +S P + L NG +++ F ++ Y+ + Sbjct: 344 FCFSVRFKAYPQIRCT---WTFSRKSFPCEQK-GLDNG-YSISKFCNHKHQPGEYIFHAE 398 Query: 575 NSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWR 628 N A + TL++ P +++ +S SC S P P ++W+ Sbjct: 399 ND-DAQFTKMFTLNIRRKPQ--VLAEASAS-------QASCFSDGYPLPSWTWK 442 >1FSK-B nrPDB Length = 214 Score = 28.9 bits (63), Expect = 7.5, Method: Compositional matrix adjust. Identities = 36/143 (25%), Positives = 52/143 (36%), Gaps = 25/143 (17%) Query: 339 DAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQL------------------SNDNRTLTL 380 + V L+C+ TY++W Q SP+L L S + TLT+ Sbjct: 17 ERVTLSCKASENVDTYVFWFQ-QKPDQSPKLLLYGPSNRYTGVPDRFTGSGSTTDFTLTI 75 Query: 381 LSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS---PSYTYYRPGVNLSLSC 437 SV D+ Y CG L + PT+S PS G S+ C Sbjct: 76 SSVQAEDLADYHCGQSYSYPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSG-GASVVC 134 Query: 438 HAASNPPAQ--YSWLIDGNIQQH 458 + P W IDG+ +Q+ Sbjct: 135 FLNNFYPKDINVKWKIDGSERQN 157 >4PBV-A nrPDB Length = 268 Score = 28.9 bits (63), Expect = 8.3, Method: Compositional matrix adjust. Identities = 26/93 (27%), Positives = 45/93 (48%), Gaps = 15/93 (16%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-----GTFQQSTQ-------ELFIPN 288 ++S +N + R GEN ++C + +P W V T Q + Q +L + N Sbjct: 170 SVSHVNLTVREGENAVITCQGSGSPLPDVDWTVADLHSINTHQTNLQWTNVHAIQLTLVN 229 Query: 289 ITVNNSGS-YTCQAHNSDTGLNRTTVTTITVYA 320 +T ++G TC A N G+++ +V +TVY Sbjct: 230 VTSEDNGFLLTCIAENV-VGMSQASV-LLTVYG 260 >4PBW-B nrPDB Length = 283 Score = 28.9 bits (63), Expect = 8.4, Method: Compositional matrix adjust. Identities = 26/93 (27%), Positives = 45/93 (48%), Gaps = 15/93 (16%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-----GTFQQSTQ-------ELFIPN 288 ++S +N + R GEN ++C + +P W V T Q + Q +L + N Sbjct: 185 SVSHVNLTVREGENAVITCQGSGSPLPDVDWTVADLHSINTHQTNLQWTNVHAIQLTLVN 244 Query: 289 ITVNNSGS-YTCQAHNSDTGLNRTTVTTITVYA 320 +T ++G TC A N G+++ +V +TVY Sbjct: 245 VTSEDNGFLLTCIAENV-VGMSQASV-LLTVYG 275 >4DEP-B nrPDB Length = 321 Score = 28.9 bits (63), Expect = 8.7, Method: Compositional matrix adjust. Identities = 21/80 (26%), Positives = 35/80 (43%), Gaps = 6/80 (7%) Query: 462 LFISNITEKNSGLYTCQANNSASGHSR---TTVKTITVSAELP-KPSISS--NNSKPVED 515 L + N+ EK+ G YTC A+ + G ++ IT+ P +P I S N + V+ Sbjct: 166 LIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVDL 225 Query: 516 KDAVAFTCEPEAQNTTYLWW 535 + C Q + +W Sbjct: 226 GSQIQLICNVTGQLSDIAYW 245 >1QGC-4 nrPDB Length = 218 Score = 28.9 bits (63), Expect = 8.8, Method: Compositional matrix adjust. Identities = 25/92 (27%), Positives = 39/92 (42%), Gaps = 6/92 (6%) Query: 550 SNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSYLS 607 S + TLT+ V +D Y C N V LD+ P +S PP S L+ Sbjct: 71 SRTDFTLTIDPVEADDVATYYCQQSNEVPLTFGAGTKLDLKRADAAPTVSIFPPSSEQLT 130 Query: 608 GANLNLSCHSASNPSPQ---YSWRINGIPQQH 636 ++ C +N P+ W+I+G +Q+ Sbjct: 131 SGGASVVCF-LNNFYPKDINVKWKIDGSERQN 161 >1IAI-M nrPDB Length = 215 Score = 28.5 bits (62), Expect = 9.1, Method: Compositional matrix adjust. Identities = 28/112 (25%), Positives = 47/112 (41%), Gaps = 11/112 (9%) Query: 535 WVNGQS-----LPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDV 589 W+ G S +PV S + +LT+ ++ DA Y C NS L++ Sbjct: 48 WIYGTSNLASGVPVRFSGSGSGTSYSLTISSMEAEDAATYYCQQWNSYPYTFGGGTKLEI 107 Query: 590 LYGPDTPIIS--PPDSSYLSGANLNLSCHSASNPSPQ---YSWRINGIPQQH 636 P +S PP S L+ ++ C +N P+ W+I+G +Q+ Sbjct: 108 KRADAAPTVSIFPPSSEQLTSGGASVVCF-LNNFYPKDINVKWKIDGSERQN 158 >6J8G-B nrPDB Length = 218 Score = 28.5 bits (62), Expect = 9.5, Method: Composition-based stats. Identities = 21/67 (31%), Positives = 30/67 (44%), Gaps = 4/67 (5%) Query: 640 LFIAKITPNNNGTYACFVSNLA----TGRNNSIVKSITVSASGTSPGLSAGATVGIMIGV 695 +FI +T N++G Y C V L N S+VK I + + A IM+ V Sbjct: 106 IFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYV 165 Query: 696 LVGVALI 702 L+ V I Sbjct: 166 LIVVLTI 172 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1E07-A nrPDB 821 0.0 5OJ2-A nrPDB 382 e-106 6IAA-A nrPDB 351 7e-97 5O5G-A nrPDB 288 4e-78 3V2A-R nrPDB 279 3e-75 5Z5K-A nrPDB 260 1e-69 3JXA-A nrPDB 254 7e-68 4FOM-A nrPDB 190 2e-48 3V6B-R nrPDB 187 2e-47 6DLF-A nrPDB 186 3e-47 6DLD-B nrPDB 182 5e-46 1QZ1-A nrPDB 182 5e-46 2WIM-A nrPDB 177 2e-44 4MYW-B nrPDB 170 2e-42 3K0W-A nrPDB 167 2e-41 5VI4-B nrPDB 160 1e-39 3S97-C nrPDB 148 6e-36 Sequences not found previously or not previously below threshold: 5OYJ-C nrPDB 135 8e-32 5T89-X nrPDB 130 3e-30 4KC3-B nrPDB 126 5e-29 1EPF-A nrPDB 115 7e-26 5B22-A nrPDB 105 6e-23 2XY2-A nrPDB 102 4e-22 3BFO-A nrPDB 95 8e-20 2L7J-A nrPDB 84 2e-16 2X1X-R nrPDB 79 6e-15 3O4O-C nrPDB 78 1e-14 4DEP-B nrPDB 77 2e-14 3S35-X nrPDB 75 9e-14 1Z7Z-I nrPDB 68 2e-11 2EO9-A nrPDB 68 2e-11 6FEY-A nrPDB 66 6e-11 6A77-A nrPDB 65 1e-10 5VI4-C nrPDB 64 2e-10 3O4O-B nrPDB 63 6e-10 5FTT-A nrPDB 62 7e-10 4FRW-A nrPDB 60 3e-09 4V2A-A nrPDB 60 3e-09 1U2H-A nrPDB 60 3e-09 3QS9-E nrPDB 60 4e-09 2RCJ-C nrPDB 60 4e-09 1WIO-A nrPDB 59 6e-09 4BSJ-A nrPDB 59 6e-09 2NCM-A nrPDB 59 8e-09 1TLK-A nrPDB 59 8e-09 4Q6I-C nrPDB 58 1e-08 3O2D-A nrPDB 58 1e-08 5IMK-A nrPDB 58 1e-08 3O3U-N nrPDB 56 4e-08 1VCA-A nrPDB 56 5e-08 2IFG-A nrPDB 55 1e-07 4FMK-A nrPDB 55 1e-07 3MJ9-A nrPDB 55 1e-07 2VAJ-A nrPDB 54 2e-07 1FSK-B nrPDB 53 4e-07 1DR9-A nrPDB 53 5e-07 1KOA-A nrPDB 53 6e-07 1CFS-A nrPDB 52 9e-07 3WO4-B nrPDB 51 1e-06 1MLC-A nrPDB 51 2e-06 1QGC-4 nrPDB 51 2e-06 3UTO-A nrPDB 50 3e-06 1C12-A nrPDB 50 3e-06 4PBV-A nrPDB 50 3e-06 4PBW-B nrPDB 50 4e-06 1WEJ-L nrPDB 49 7e-06 1KCU-L nrPDB 49 7e-06 3F7V-B nrPDB 48 9e-06 1IGY-A nrPDB 48 9e-06 1CIC-A nrPDB 48 1e-05 4BFI-B nrPDB 48 1e-05 1CT8-A nrPDB 48 1e-05 3O11-L nrPDB 48 1e-05 1KNO-A nrPDB 48 1e-05 2AEP-L nrPDB 48 1e-05 1E4W-L nrPDB 48 2e-05 1KCR-L nrPDB 48 2e-05 1HNF-A nrPDB 47 2e-05 3QS7-E nrPDB 47 2e-05 1FNS-L nrPDB 47 2e-05 2AJV-L nrPDB 47 3e-05 1AHW-A nrPDB 47 3e-05 4XNZ-L nrPDB 47 3e-05 1Q0Y-L nrPDB 46 4e-05 1D5B-A nrPDB 46 4e-05 2F58-L nrPDB 46 4e-05 1OLZ-A nrPDB 46 5e-05 1EMT-L nrPDB 46 7e-05 6FAB-L nrPDB 46 8e-05 1MH5-A nrPDB 45 1e-04 1IAI-M nrPDB 45 1e-04 4BFE-A nrPDB 45 1e-04 4BFG-A nrPDB 45 1e-04 1FBI-L nrPDB 45 2e-04 1JN6-A nrPDB 44 2e-04 2QHR-L nrPDB 44 2e-04 4JJH-A nrPDB 44 2e-04 4D3C-L nrPDB 44 2e-04 5VF3-Z nrPDB 44 3e-04 1UB5-L nrPDB 44 3e-04 4QNP-F nrPDB 44 3e-04 1HNG-A nrPDB 43 3e-04 1RUQ-L nrPDB 43 3e-04 4XXD-A nrPDB 43 4e-04 1UCB-L nrPDB 43 4e-04 1GPO-L nrPDB 43 4e-04 5A2I-H nrPDB 43 4e-04 1BBD-L nrPDB 43 5e-04 3U0W-L nrPDB 43 6e-04 1WWC-A nrPDB 43 6e-04 1OTS-D nrPDB 42 7e-04 2XOT-A nrPDB 42 7e-04 1PSK-L nrPDB 42 7e-04 2FD6-L nrPDB 42 8e-04 1HKL-L nrPDB 42 8e-04 6DCW-L nrPDB 42 0.001 4BSK-A nrPDB 42 0.001 1A0Q-L nrPDB 42 0.001 2DRU-A nrPDB 41 0.001 1A7O-L nrPDB 41 0.001 1SEQ-L nrPDB 41 0.001 4YDV-L nrPDB 41 0.001 4GJT-B nrPDB 41 0.001 1KEN-L nrPDB 41 0.001 1HEZ-A nrPDB 41 0.001 1ZVO-A nrPDB 41 0.001 1SM3-L nrPDB 41 0.002 1KCS-L nrPDB 41 0.002 1MF2-L nrPDB 41 0.002 4OIB-A nrPDB 41 0.002 2JB5-L nrPDB 41 0.002 4XNY-L nrPDB 41 0.002 2ZNW-A nrPDB 41 0.002 5NQK-B nrPDB 41 0.002 1LIL-A nrPDB 40 0.003 4HIX-L nrPDB 40 0.003 3OAI-A nrPDB 40 0.003 7FAB-L nrPDB 40 0.003 1H3P-L nrPDB 40 0.003 1HDM-B nrPDB 40 0.003 1SVZ-A nrPDB 40 0.004 1UWX-K nrPDB 40 0.004 3NVQ-A nrPDB 40 0.004 1NEU-A nrPDB 40 0.005 4XMP-L nrPDB 40 0.005 1MIM-L nrPDB 40 0.005 1N26-A nrPDB 40 0.005 5X5W-B nrPDB 39 0.006 4L1D-A nrPDB 39 0.006 1ORQ-A nrPDB 39 0.006 4LLY-B nrPDB 39 0.007 5B21-A nrPDB 39 0.007 1F6L-L nrPDB 39 0.008 1HZH-L nrPDB 39 0.009 1OSP-L nrPDB 38 0.011 6DE7-L nrPDB 38 0.011 2BNU-B nrPDB 38 0.012 1T7V-A nrPDB 38 0.014 4EOW-L nrPDB 38 0.016 6J8I-C nrPDB 38 0.018 4NHU-B nrPDB 38 0.020 2ADF-H nrPDB 38 0.020 1HCF-X nrPDB 38 0.021 1AQK-L nrPDB 37 0.021 4NM4-L nrPDB 37 0.025 3MCG-1 nrPDB 37 0.026 5XCS-B nrPDB 37 0.033 4AIZ-B nrPDB 36 0.039 1M71-B nrPDB 36 0.042 5MO9-X nrPDB 36 0.043 1CCZ-A nrPDB 36 0.044 6IGW-A nrPDB 36 0.053 3MOQ-A nrPDB 36 0.059 3UEZ-A nrPDB 36 0.062 3KHO-B nrPDB 36 0.062 2IG2-H nrPDB 36 0.067 1QFW-L nrPDB 36 0.069 5MZA-B nrPDB 35 0.082 1CF8-L nrPDB 35 0.088 5K8D-B nrPDB 35 0.099 1QFW-M nrPDB 35 0.099 1MQ8-A nrPDB 35 0.10 1I7Z-A nrPDB 35 0.11 5EU6-D nrPDB 35 0.13 5XCV-B nrPDB 35 0.14 5MXA-A nrPDB 35 0.16 5XSY-B nrPDB 35 0.16 25C8-L nrPDB 35 0.17 1HZH-H nrPDB 35 0.18 5V52-C nrPDB 34 0.18 3F7R-A nrPDB 34 0.19 5XCV-A nrPDB 34 0.19 1I8K-A nrPDB 34 0.19 4CKD-L nrPDB 34 0.20 1DVF-C nrPDB 34 0.23 1BII-A nrPDB 34 0.30 1ZVO-C nrPDB 33 0.31 5HHM-D nrPDB 33 0.34 1ZS8-A nrPDB 33 0.34 6CQN-D nrPDB 33 0.34 2BNR-D nrPDB 33 0.37 3KG5-A nrPDB 33 0.37 2PTT-A nrPDB 33 0.40 1DLF-L nrPDB 33 0.40 4K0V-A nrPDB 33 0.41 5YD3-A nrPDB 33 0.44 6J8G-B nrPDB 33 0.45 4L1H-A nrPDB 33 0.45 5F4V-A nrPDB 33 0.47 2OZ4-H nrPDB 33 0.49 4PFE-A nrPDB 33 0.63 5XCQ-B nrPDB 32 0.71 6J8E-C nrPDB 32 0.73 4PD4-K nrPDB 32 0.76 1A14-L nrPDB 32 0.78 1XAU-A nrPDB 32 0.79 4KKN-A nrPDB 32 0.83 1BFV-L nrPDB 32 0.88 3UPA-A nrPDB 32 0.91 4I18-R nrPDB 32 0.94 2X44-D nrPDB 32 0.95 2G2R-H nrPDB 32 0.95 3FG7-A nrPDB 32 1.0 5C09-D nrPDB 32 1.1 3U0W-H nrPDB 31 1.2 2FB4-L nrPDB 31 1.3 1JFQ-H nrPDB 31 1.4 5XP1-A nrPDB 31 1.8 4N8P-A nrPDB 31 2.1 1AO7-D nrPDB 31 2.5 4WW2-A nrPDB 31 2.6 4Q58-C nrPDB 30 2.8 6DKP-D nrPDB 30 3.1 1PEW-A nrPDB 30 3.1 2Q20-A nrPDB 30 3.6 2EDO-A nrPDB 30 4.3 3AB0-C nrPDB 30 4.5 1WTL-A nrPDB 30 5.3 3TYG-L nrPDB 29 8.9 >1E07-A nrPDB Length = 642 Score = 821 bits (2120), Expect = 0.0, Method: Composition-based stats. Identities = 641/642 (99%), Positives = 642/642 (100%) Query: 35 KLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPA 94 KLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPA Sbjct: 1 KLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPA 60 Query: 95 YSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNS 154 YSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNS Sbjct: 61 YSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNS 120 Query: 155 KPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYK 214 KPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYK Sbjct: 121 KPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYK 180 Query: 215 CETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN 274 CETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN Sbjct: 181 CETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN 240 Query: 275 GTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 GTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP Sbjct: 241 GTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP 300 Query: 335 VEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECG 394 VEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECG Sbjct: 301 VEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECG 360 Query: 395 IQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGN 454 IQN+LSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGN Sbjct: 361 IQNELSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGN 420 Query: 455 IQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVE 514 IQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVE Sbjct: 421 IQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVE 480 Query: 515 DKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQ 574 DKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQ Sbjct: 481 DKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQ 540 Query: 575 NSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQ 634 NSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQ Sbjct: 541 NSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQ 600 Query: 635 QHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSA 676 QHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSA Sbjct: 601 QHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSA 642 Score = 380 bits (976), Expect = e-106, Method: Composition-based stats. Identities = 268/421 (63%), Positives = 302/421 (71%), Gaps = 4/421 (0%) Query: 265 PPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPK 324 P YS L I NI N++G YT SD +N VY E PK Sbjct: 57 PGPAYS---GREIIYPNASLLIQNIIQNDTGFYTLHVIKSDL-VNEEATGQFRVYPELPK 112 Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVT 384 P I+SNNS PVED+DAVA TCEPE Q+ TYLWWVNNQSLPVSPRLQLSN NRTLTL +VT Sbjct: 113 PSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVT 172 Query: 385 RNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPP 444 RND Y+C QN +S SD VILNVLYGPD PTISP T YR G NL+LSCHAASNPP Sbjct: 173 RNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPP 232 Query: 445 AQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPS 504 AQYSW ++G QQ TQELFI NIT NSG YTCQA+NS +G +RTTV TITV AE PKP Sbjct: 233 AQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPF 292 Query: 505 ISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRN 564 I+SNNS PVED+DAVA TCEPE QNTTYLWWVN QSLPVSPRLQLSN NRTLTL +VTRN Sbjct: 293 ITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRN 352 Query: 565 DARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQ 624 D Y CGIQN +S + SDPV L+VLYGPD P ISP + Y G NL+LSCH+ASNP Q Sbjct: 353 DVGPYECGIQNELSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQ 412 Query: 625 YSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLS 684 YSW I+G QQHTQ LFI+ IT N+G Y C +N A+G + + VK+ITVSA P +S Sbjct: 413 YSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSIS 472 Query: 685 A 685 + Sbjct: 473 S 473 Score = 375 bits (962), Expect = e-104, Method: Composition-based stats. Identities = 271/469 (57%), Positives = 311/469 (66%), Gaps = 30/469 (6%) Query: 31 PTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQAT 90 P ++ +T + E + + P YSW+ + Q Sbjct: 203 PDAPTISPLNTSYRSGENLNLSCHAASNPPAQ--YSWFVNGTFQQSTQ------------ 248 Query: 91 PGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSD-LVNEEATGQFRVYPELPKPSI 149 L I NI N++G YT SD +N VY E PKP I Sbjct: 249 ---------------ELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFI 293 Query: 150 SSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRND 209 +SNNS PVED+DAVA TCEPE Q+ TYLWWVNNQSLPVSPRLQLSN NRTLTL +VTRND Sbjct: 294 TSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRND 353 Query: 210 TASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQY 269 Y+C QN +S SD VILNVLYGPD PTISP T YR G NL+LSCHAASNPPAQY Sbjct: 354 VGPYECGIQNELSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQY 413 Query: 270 SWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITS 329 SW ++G QQ TQELFI NIT NSG YTCQA+NS +G +RTTV TITV AE PKP I+S Sbjct: 414 SWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISS 473 Query: 330 NNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVG 389 NNS PVED+DAVA TCEPE QNTTYLWWVN QSLPVSPRLQLSN NRTLTL +VTRND Sbjct: 474 NNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDAR 533 Query: 390 PYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSW 449 Y CGIQN +S + SDPV L+VLYGPD P ISP + Y G NL+LSCH+ASNP QYSW Sbjct: 534 AYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSW 593 Query: 450 LIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSA 498 I+G QQHTQ LFI+ IT N+G Y C +N A+G + + VK+ITVSA Sbjct: 594 RINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSA 642 >5OJ2-A nrPDB Length = 910 Score = 382 bits (981), Expect = e-106, Method: Composition-based stats. Identities = 121/577 (20%), Positives = 208/577 (36%), Gaps = 79/577 (13%) Query: 156 PVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKC 215 + + D + C + W + S N TL + + R Y C Sbjct: 31 TIREGDTLVLQCLVTGHPRPQVRWTKTAGSASDKFQETSVLNETLRIEKIQRLQGGRYYC 90 Query: 216 ETQNPVSARRSDSVILNVLYGPDA-----PTISPLNTSYRSGENLNLSCHAASNPPAQYS 270 + +N V S+ ++V Y + TIS + S+ + + L C SNPPA++ Sbjct: 91 KAENGVGVPAIKSIRVDVQYLDEPVLTVHQTISDVRGSFYQEKTVFLRCTVNSNPPARFI 150 Query: 271 WFVNGT-----------------FQQSTQELFIPNITVNNSGSYTCQ--AHNSDTGLNRT 311 W Q T+ L + N+ + SYTCQ N + +++ Sbjct: 151 WKRGAETLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVCSIPDKS 210 Query: 312 TVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQ--NTTYLWWVNNQSLPVSPRL 369 +T PP ++ N + V D V + C LW + LP + + Sbjct: 211 ITFQLTNTTAPPALKLSVNETLVVNPGDNVTMQCSLTGGDPQPEVLWSHSPGPLPPNSLV 270 Query: 370 QLSNDNRTLTLLSVTRNDVGPYECGIQN------KLSVDHSDPVILNVLYGPDDPTISPS 423 Q LT+ + D G Y C N K +V+ + N + I S Sbjct: 271 Q----GGNLTIWRIRVEDSGYYNCTAINNVGNPAKKTVNLLVRSMKNATFQITPDVIKES 326 Query: 424 YTYYRPGVNLSLSCHAASNPPAQ--YSWLIDGNIQQHTQELFIS---------------- 465 T + G +L LSCH + P + YSW +G + + L I+ Sbjct: 327 ET-IQLGQDLKLSCHVDAVPQEKVVYSWYKNGKPARFSDRLLITRNDPELPPVTCSLEII 385 Query: 466 NITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSIS---SNNSKPVEDKDAVAFT 522 ++ + G Y C A + +V + +S+E P+IS ++ V + Sbjct: 386 DLRFSDYGTYLCVATFQGAPIPDLSV-EVNISSETVPPTISVPKGQSTITVREGSRAELQ 444 Query: 523 CEPEAQNTTYLWW--VNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSAN 580 CE + + W V+ ++ S + + + L L +V+R+ + Y C N Sbjct: 445 CEVRGKPKPPIIWSRVDKETPMPSGTMTVETYDGKLRLESVSRDMSGTYKCQTARYNGFN 504 Query: 581 ---RSDPVTLDVLYGPDTPIISPP--DSSYLSGANLNLSCHSASNPSPQYS---WRINGI 632 R V L+V + P ++ P D G ++ L C + + WR NG Sbjct: 505 IRPREALVQLNVQFPP---VVEPAFQDVRQGMGRSVTLRCTMLKGSPMKVATSVWRFNGT 561 Query: 633 -------PQQHTQVLFIAKITPNNNGTYACFVSNLAT 662 QQ L + ++ +G+Y C +SN Sbjct: 562 LLAQPPAEQQDYSELKVDSVSRETSGSYECSISNDVG 598 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 89/423 (21%), Positives = 145/423 (34%), Gaps = 61/423 (14%) Query: 19 LLTASL--LTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGN 76 LL S+ TF P K ES + + ++ V +PQ YSWYK + Sbjct: 306 LLVRSMKNATFQITPDVIK---ESETIQLGQDLKLSCHVDAVPQEKVVYSWYKNGK---- 358 Query: 77 RQIIGYVIGTQQATPGPA-YSGREIIYPN--------ASLLIQNIIQNDTGFYTLHVIKS 127 PA +S R +I N SL I ++ +D G Y Sbjct: 359 ----------------PARFSDRLLITRNDPELPPVTCSLEIIDLRFSDYGTYLCVATFQ 402 Query: 128 DLVNEEATGQFRVYPELPKPSIS---SNNSKPVEDKDAVAFTCEPETQDATYLWW--VNN 182 + + + + E P+IS ++ V + CE + + W V+ Sbjct: 403 GAPIPDLSVEVNISSETVPPTISVPKGQSTITVREGSRAELQCEVRGKPKPPIIWSRVDK 462 Query: 183 QSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSA---RRSDSVILNVLYGPDA 239 ++ S + + + L L +V+R+ + +YKC+T R V LNV + Sbjct: 463 ETPMPSGTMTVETYDGKLRLESVSRDMSGTYKCQTARYNGFNIRPREALVQLNVQF---P 519 Query: 240 PTISPL--NTSYRSGENLNLSCHA-ASNP--PAQYSWFVNGTF-------QQSTQELFIP 287 P + P + G ++ L C +P A W NGT QQ EL + Sbjct: 520 PVVEPAFQDVRQGMGRSVTLRCTMLKGSPMKVATSVWRFNGTLLAQPPAEQQDYSELKVD 579 Query: 288 NITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEP 347 +++ SGSY C N + Y P + T N + + + + Sbjct: 580 SVSRETSGSYECSISNDVGVSACLFQVSAKAY-SPEFYYDTPNPTLSQKQSKNYSYILQW 638 Query: 348 EIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPV 407 + + QL+ N T + V + + G I L V S V Sbjct: 639 TQKEPDAVD---PILKYRLEVRQLAQRNTIQTFIPVQKMEKGLLLEHILPNLKVPQSYEV 695 Query: 408 ILN 410 L Sbjct: 696 RLT 698 Score = 165 bits (417), Expect = 6e-41, Method: Composition-based stats. Identities = 84/425 (19%), Positives = 139/425 (32%), Gaps = 54/425 (12%) Query: 309 NRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPR 368 A K S + + D + L C + W Sbjct: 6 PAQAQIIHAGQACVVKEDNISERVYTIREGDTLVLQCLVTGHPRPQVRWTKTAGSASDKF 65 Query: 369 LQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYR 428 + S N TL + + R G Y C +N + V + ++V Y + Sbjct: 66 QETSVLNETLRIEKIQRLQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPVLTVHQTISDV 125 Query: 429 PG-----VNLSLSCHAASNPPAQYSWLIDGNIQQHTQE-----------------LFISN 466 G + L C SNPPA++ W H+Q+ L + N Sbjct: 126 RGSFYQEKTVFLRCTVNSNPPARFIWKRGAETLSHSQDNGVDIYEPLYTQGETKVLKLKN 185 Query: 467 ITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPS--ISSNNSKPVEDKDAVAFTCE 524 + ++ YTCQ + T ++ P+ +S N + V D V C Sbjct: 186 LRPQDYASYTCQVSVRNVCSIPDKSITFQLTNTTAPPALKLSVNETLVVNPGDNVTMQCS 245 Query: 525 PEAQNTTY--LWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRS 582 + LW + LP + +Q LT++ + D+ Y C N+V Sbjct: 246 LTGGDPQPEVLWSHSPGPLPPNSLVQ----GGNLTIWRIRVEDSGYYNCTAINNVGNPAK 301 Query: 583 DPVTLDVLYGPD-----TPIISPPDSSYLSGANLNLSCHSASNPSPQ--YSWRINGIPQQ 635 V L V + TP + + G +L LSCH + P + YSW NG P + Sbjct: 302 KTVNLLVRSMKNATFQITPDVIKESETIQLGQDLKLSCHVDAVPQEKVVYSWYKNGKPAR 361 Query: 636 HTQVLFIA----------------KITPNNNGTYACFVSNLATGRNNSIVKSITVSASGT 679 + L I + ++ GTY C + + V+ + +S+ Sbjct: 362 FSDRLLITRNDPELPPVTCSLEIIDLRFSDYGTYLCVATFQGAPIPDLSVE-VNISSETV 420 Query: 680 SPGLS 684 P +S Sbjct: 421 PPTIS 425 Score = 161 bits (406), Expect = 1e-39, Method: Composition-based stats. Identities = 105/557 (18%), Positives = 180/557 (32%), Gaps = 56/557 (10%) Query: 98 REIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPV 157 +E N +L I+ I + G Y V + + V V Sbjct: 66 QETSVLNETLRIEKIQRLQGGRYYCKAENGVGVPAIKSIRVDVQYLDEPVLTVHQTISDV 125 Query: 158 E----DKDAVAFTCEPETQDAT-YLWWVNNQSLPVSPRLQL--------SNGNRTLTLFN 204 + V C + ++W ++L S + + L L N Sbjct: 126 RGSFYQEKTVFLRCTVNSNPPARFIWKRGAETLSHSQDNGVDIYEPLYTQGETKVLKLKN 185 Query: 205 VTRNDTASYKC--ETQNPVSAR-RSDSVILNVLYGPDAPTISPLNT-SYRSGENLNLSCH 260 + D ASY C +N S +S + L P A +S T G+N+ + C Sbjct: 186 LRPQDYASYTCQVSVRNVCSIPDKSITFQLTNTTAPPALKLSVNETLVVNPGDNVTMQCS 245 Query: 261 -AASNPPAQYSWFVNGTFQQSTQ-----ELFIPNITVNNSGSYTCQAHNSDTGLNRTTVT 314 +P + W + L I I V +SG Y C A N+ + TV Sbjct: 246 LTGGDPQPEVLWSHSPGPLPPNSLVQGGNLTIWRIRVEDSGYYNCTAINNVGNPAKKTVN 305 Query: 315 TITVYAEPPKPFITSN---NSNPVEDEDAVALTC---EPEIQNTTYLWWVNNQSLPVSPR 368 + + IT + S ++ + L+C + Y W+ N + S R Sbjct: 306 LLVRSMKNATFQITPDVIKESETIQLGQDLKLSCHVDAVPQEKVVYSWYKNGKPARFSDR 365 Query: 369 LQLSND-------NRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS 421 L ++ + +L ++ + +D G Y C + + V +N+ PTIS Sbjct: 366 LLITRNDPELPPVTCSLEIIDLRFSDYGTYLCVATFQGAPIPDLSVEVNISSETVPPTIS 425 Query: 422 P----SYTYYRPGVNLSLSCHAASNPPAQYSWLIDGN----------IQQHTQELFISNI 467 S R G L C P W ++ + +L + ++ Sbjct: 426 VPKGQSTITVREGSRAELQCEVRGKPKPPIIWSRVDKETPMPSGTMTVETYDGKLRLESV 485 Query: 468 TEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCE-PE 526 + SG Y CQ + R + ++ + P + +V C + Sbjct: 486 SRDMSGTYKCQTARYNGFNIRPREALVQLNVQFPPVVEPAFQDVRQGMGRSVTLRCTMLK 545 Query: 527 AQNT---TYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSD 583 T +W NG L P Q L + +V+R + +Y C I N V + Sbjct: 546 GSPMKVATSVWRFNGTLLAQPPAEQ--QDYSELKVDSVSRETSGSYECSISNDVGVSACL 603 Query: 584 PVTLDVLYGPDTPIISP 600 Y P+ +P Sbjct: 604 FQVSAKAYSPEFYYDTP 620 Score = 155 bits (392), Expect = 5e-38, Method: Composition-based stats. Identities = 90/474 (18%), Positives = 158/474 (33%), Gaps = 59/474 (12%) Query: 242 ISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNG-----TFQQS---TQELFIPNITVNN 293 IS + R G+ L L C +P Q W FQ++ + L I I Sbjct: 25 ISERVYTIREGDTLVLQCLVTGHPRPQVRWTKTAGSASDKFQETSVLNETLRIEKIQRLQ 84 Query: 294 SGSYTCQAHN-SDTGLNRTTVTTITVYAEPPKPFITSNNSNPVE--DEDAVALTCEPEIQ 350 G Y C+A N ++ + EP + + E V L C Sbjct: 85 GGRYYCKAENGVGVPAIKSIRVDVQYLDEPVLTVHQTISDVRGSFYQEKTVFLRCTVNSN 144 Query: 351 NTT---------YLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYEC--GIQNKL 399 L + + + L + + L L ++ D Y C ++N Sbjct: 145 PPARFIWKRGAETLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSVRNVC 204 Query: 400 SVDHSDPVILNVL-YGPDDPTISPSYTYYR-PGVNLSLSCHAA-SNPPAQYSW------L 450 S+ P +S + T PG N+++ C +P + W L Sbjct: 205 SIPDKSITFQLTNTTAPPALKLSVNETLVVNPGDNVTMQCSLTGGDPQPEVLWSHSPGPL 264 Query: 451 IDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSI---SS 507 ++ Q L I I ++SG Y C A N+ ++ TV + S + I Sbjct: 265 PPNSLVQ-GGNLTIWRIRVEDSGYYNCTAINNVGNPAKKTVNLLVRSMKNATFQITPDVI 323 Query: 508 NNSKPVEDKDAVAFTCEPEAQN---TTYLWWVNGQSLPVSPRLQLSNGNR-------TLT 557 S+ ++ + +C +A Y W+ NG+ S RL ++ + +L Sbjct: 324 KESETIQLGQDLKLSCHVDAVPQEKVVYSWYKNGKPARFSDRLLITRNDPELPPVTCSLE 383 Query: 558 LFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPP----DSSYLSGANLNL 613 + ++ +D Y+C + V +++ P IS P + G+ L Sbjct: 384 IIDLRFSDYGTYLCVATFQGAPIPDLSVEVNISSETVPPTISVPKGQSTITVREGSRAEL 443 Query: 614 SCHSASNPSPQYSWRI--NGIP--------QQHTQVLFIAKITPNNNGTYACFV 657 C P P W P + + L + ++ + +GTY C Sbjct: 444 QCEVRGKPKPPIIWSRVDKETPMPSGTMTVETYDGKLRLESVSRDMSGTYKCQT 497 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 79/425 (18%), Positives = 138/425 (32%), Gaps = 46/425 (10%) Query: 90 TPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQF------RVYPE 143 +PGP + +L I I D+G+Y I + + T + Sbjct: 260 SPGPLPPNSLVQ--GGNLTIWRIRVEDSGYYNCTAINNVGNPAKKTVNLLVRSMKNATFQ 317 Query: 144 LPKPSISSNNSKPVEDKDAVAFTCEPETQDAT---YLWWVNNQSLPVSPRLQLSNGNR-- 198 + I + + + + +C + Y W+ N + S RL ++ + Sbjct: 318 ITPDVIKESETIQL--GQDLKLSCHVDAVPQEKVVYSWYKNGKPARFSDRLLITRNDPEL 375 Query: 199 -----TLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS----PLNTSY 249 +L + ++ +D +Y C + SV +N+ PTIS + Sbjct: 376 PPVTCSLEIIDLRFSDYGTYLCVATFQGAPIPDLSVEVNISSETVPPTISVPKGQSTITV 435 Query: 250 RSGENLNLSCHAASNPPAQYSWFV--------NGTFQQSTQE--LFIPNITVNNSGSYTC 299 R G L C P W +GT T + L + +++ + SG+Y C Sbjct: 436 REGSRAELQCEVRGKPKPPIIWSRVDKETPMPSGTMTVETYDGKLRLESVSRDMSGTYKC 495 Query: 300 QAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCE----PEIQNTTYL 355 Q + R + + + P + +V L C ++ T + Sbjct: 496 QTARYNGFNIRPREALVQLNVQFPPVVEPAFQDVRQGMGRSVTLRCTMLKGSPMKVATSV 555 Query: 356 WWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGP 415 W N L P Q D L + SV+R G YEC I N + V + Y P Sbjct: 556 WRFNGTLLAQPPAEQ--QDYSELKVDSVSRETSGSYECSISNDVGVSACLFQVSAKAYSP 613 Query: 416 DDPTISPSYTY-YRPGVNLSL-----SCHAASNPPAQYSWLIDGNIQQHTQELFISNITE 469 + +P+ T + N S + P L + Q + + Sbjct: 614 EFYYDTPNPTLSQKQSKNYSYILQWTQKEPDAVDPILKYRLEVRQLAQRNTIQTFIPVQK 673 Query: 470 KNSGL 474 GL Sbjct: 674 MEKGL 678 >6IAA-A nrPDB Length = 859 Score = 351 bits (899), Expect = 7e-97, Method: Composition-based stats. Identities = 103/502 (20%), Positives = 165/502 (32%), Gaps = 58/502 (11%) Query: 228 SVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQE---- 283 L P P + GE L+C A P W+ +G ++ ++ Sbjct: 11 HSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS 70 Query: 284 ---------LFIPNITVN-----NSGSYTCQAHNS-DTGLNRTTVTTITVYAEPPKPFIT 328 LF I + GSY C A N ++R + + + F Sbjct: 71 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRD---DFRQ 127 Query: 329 SNNSNPVEDEDAVALTCEPEIQ-NTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRND 387 + V + L C+P ++W ++ ++S L + + ++D Sbjct: 128 NPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSD 187 Query: 388 VGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQY 447 G Y C N + SDP L V P P + C +P Sbjct: 188 AGMYTCVGTNMVGERDSDPAELTVFERPT-FLRRPINQVVLEEEAVEFRCQVQGDPQPTV 246 Query: 448 SWLID------GNIQ-QHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAEL 500 W D G + L I + G Y C A N + T++ Sbjct: 247 RWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASA----TLTVRA 302 Query: 501 PKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQS----LPVSPRLQLSNGNRT- 555 P + + V V F CE + ++W S P P+ S + + Sbjct: 303 PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSP 362 Query: 556 ---LTLFNVTRNDARAYVCG---IQNSVSANRSDPVTLDVLYGPDTPII--SPPDSSYLS 607 LT+ N+ R+DA Y+C + S+ A VT DVL PII P + + Sbjct: 363 TGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVT-DVLTDRPPPIILQGPANQTLAV 421 Query: 608 GANLNLSCHSASNPSPQYSWRINGIPQ---------QHTQVLFIAKITPNNNGTYACFVS 658 L C + +P P SW G Q L I + ++ GTY C + Sbjct: 422 DGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVAT 481 Query: 659 NLATGRNNSIVKSITVSASGTS 680 + + + S V +T S + S Sbjct: 482 SSSGETSWSAVLDVTESGATIS 503 Score = 263 bits (672), Expect = 2e-70, Method: Composition-based stats. Identities = 98/485 (20%), Positives = 161/485 (33%), Gaps = 49/485 (10%) Query: 145 PKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVN-------NQSLPVSPRLQLSNGN 197 P + + V + C+ E + + W ++ P S R+ L +G Sbjct: 20 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSG- 78 Query: 198 RTLTLFNV-----TRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSG 252 +L + ++ D SY C +N + S + L V D +P + +G Sbjct: 79 -SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 137 Query: 253 ENLNLSC-HAASNPPAQYSWFVNGTFQQSTQE--------LFIPNITVNNSGSYTCQAHN 303 E L C +P W + +E L I N +++G YTC N Sbjct: 138 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTN 197 Query: 304 SDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSL 363 G + +TV+ P F+ + V +E+AV C+ + + W + + Sbjct: 198 M-VGERDSDPAELTVFERPT--FLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDAD 254 Query: 364 PVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPS 423 R + +D TL + D G Y C +N++ L V P + P Sbjct: 255 LPRGRYDIKDD-YTLRIKKTMSTDEGTYMCIAENRVGK-MEASATLTVR-APPQFVVRPR 311 Query: 424 YTYYRPGVNLSLSCHAASNPPAQYSWLIDG--------NIQQHTQE--------LFISNI 467 G ++ C NP W +G QQ L I+NI Sbjct: 312 DQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNI 371 Query: 468 TEKNSGLYTCQANNSASGHSRTTVKTIT-VSAELPKPSI-SSNNSKPVEDKDAVAFTCEP 525 ++G Y CQA A +T V + P P I ++ + C+ Sbjct: 372 QRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKA 431 Query: 526 EAQNTTYL-WWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDP 584 + W G + P TL + N+ +D Y C +S S Sbjct: 432 TGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSG-ETSWS 490 Query: 585 VTLDV 589 LDV Sbjct: 491 AVLDV 495 Score = 242 bits (616), Expect = 5e-64, Method: Composition-based stats. Identities = 84/399 (21%), Positives = 137/399 (34%), Gaps = 46/399 (11%) Query: 322 PPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNN-------QSLPVSPRLQLSND 374 PP+ ++ V + L C+ E + T + W + + P S R+ L Sbjct: 20 PPRIVEHPSDV-IVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLP-- 76 Query: 375 NRTLTLLSV-----TRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRP 429 + +L L + ++ D G Y C +N L S L V DD +P+ Sbjct: 77 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAA 136 Query: 430 GVNLSLSCHA-ASNPPAQYSWLID--------GNIQQHTQELFISNITEKNSGLYTCQAN 480 G L C +P W D I +L ISN + ++G+YTC Sbjct: 137 GEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGT 196 Query: 481 NSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQS 540 N G + +TV + ++ V +++AV F C+ + + W + Sbjct: 197 NMV-GERDSDPAELTV--FERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDA 253 Query: 541 LPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISP 600 R + + + TL + D Y+C +N V TL V P ++ P Sbjct: 254 DLPRGRYDIKD-DYTLRIKKTMSTDEGTYMCIAENRVGK-MEASATLTVRAPPQF-VVRP 310 Query: 601 PDSSYLSGANLNLSCHSASNPSPQYSWRINGI--------PQQHT--------QVLFIAK 644 D G + C + NP P W+ G PQQ L I Sbjct: 311 RDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITN 370 Query: 645 ITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGL 683 I ++ G Y C +A +T + P + Sbjct: 371 IQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPI 409 Score = 215 bits (548), Expect = 4e-56, Method: Composition-based stats. Identities = 101/564 (17%), Positives = 174/564 (30%), Gaps = 73/564 (12%) Query: 30 PPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYK-GERVDGNRQIIGYVIGTQQ 88 P E T N P WYK GERV+ ++ Sbjct: 27 PSDVIVSKGEPTTLN--------CKAEGRPTPTI--EWYKDGERVETDKDDP-------- 68 Query: 89 ATPGPAYSGREIIYPNASLLIQNIIQN-----DTGFYTLHVIK--SDLVNEEATGQFRVY 141 ++ P+ SL I+ D G Y + V+ A+ + + Sbjct: 69 -------RSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALL 121 Query: 142 PELPKPSISSNNSKPVEDKDAVAFTCEPE-TQDATYLWWVNNQSLPVSPRLQLSNGNRTL 200 + + + V + C+P ++W ++ ++S L Sbjct: 122 RDDFRQ---NPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKL 178 Query: 201 TLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCH 260 + N ++D Y C N V R SD L V P P+N E + C Sbjct: 179 MISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPT-FLRRPINQVVLEEEAVEFRCQ 237 Query: 261 AASNPPAQYSWFVN------GTF-QQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTV 313 +P W + G + + L I + G+Y C A N + + Sbjct: 238 VQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASAT 297 Query: 314 TTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS-------LPVS 366 T+ PP+ + V V CE + ++W S P Sbjct: 298 LTV---RAPPQFVVR-PRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQ 353 Query: 367 PRLQLS-NDNRTLTLLSVTRNDVGPYEC----GIQNKLSVDHSDPVILNVLYGPDDPTIS 421 P + S + LT+ ++ R+D G Y C + L+ + + P Sbjct: 354 PNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQG 413 Query: 422 PSYTYYRPGVNLSLSCHAASNPPAQYSWLIDG---------NIQQHTQELFISNITEKNS 472 P+ L C A +P SWL +G Q L I N+ ++ Sbjct: 414 PANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDT 473 Query: 473 GLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTY 532 G YTC A +S+ S + V +T S + ++ K V + + T Sbjct: 474 GTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVT---DVTKNSVTL 530 Query: 533 LWWVNGQSLPVSPRLQLSNGNRTL 556 W + + ++++ Sbjct: 531 SWQPGTPGTLPASAYIIEAFSQSV 554 Score = 51.5 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 19/102 (18%), Positives = 30/102 (29%), Gaps = 18/102 (17%) Query: 580 NRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRING-------- 631 ++ L P + P D G L+C + P+P W +G Sbjct: 7 DKRPHSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKD 66 Query: 632 IPQQHTQ--------VLFIAKITPN--NNGTYACFVSNLATG 663 P+ H L I + + G+Y C N Sbjct: 67 DPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGE 108 >5O5G-A nrPDB Length = 385 Score = 288 bits (737), Expect = 4e-78, Method: Composition-based stats. Identities = 85/389 (21%), Positives = 134/389 (34%), Gaps = 46/389 (11%) Query: 322 PPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVN-------NQSLPVSPRLQLSND 374 PP+ ++ V + L C+ E + T + W ++ P S R+ L Sbjct: 5 PPRIVEHPSD-LIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP-- 61 Query: 375 NRTLTLLSV-----TRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRP 429 + +L L + +R D G Y C +N L S L V DD +PS Sbjct: 62 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAV 121 Query: 430 GVNLSLSCHA-ASNPPAQYSWLIDGNIQQHTQ--------ELFISNITEKNSGLYTCQAN 480 G + C +P SW DG+ +L I+ + ++G Y C Sbjct: 122 GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGT 181 Query: 481 NSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQS 540 N G + V +TV + ++ V D+ F CE + W Sbjct: 182 NMV-GERESEVAELTVLER--PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 238 Query: 541 LPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISP 600 R ++ + + TL + VT D +Y C +N V TL V P ++ P Sbjct: 239 ELPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVGKA-EASATLTVQEPPHF-VVKP 295 Query: 601 PDSSYLSGANLNLSCHSASNPSPQYSWRINGI---------PQQHTQV-------LFIAK 644 D G + C + NP P WR G PQ ++ L I Sbjct: 296 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 355 Query: 645 ITPNNNGTYACFVSNLATGRNNSIVKSIT 673 + ++ G Y C N+A +T Sbjct: 356 VQRSDVGYYICQTLNVAGSIITKAYLEVT 384 Score = 244 bits (623), Expect = 7e-65, Method: Composition-based stats. Identities = 79/388 (20%), Positives = 130/388 (33%), Gaps = 45/388 (11%) Query: 145 PKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNN-------QSLPVSPRLQLSNGN 197 P + + V + C+ E + + W + P S R+ L +G Sbjct: 5 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG- 63 Query: 198 RTLTLFNV-----TRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSG 252 +L + +R D Y C +N + S + L V D +P + G Sbjct: 64 -SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 122 Query: 253 ENLNLSC-HAASNPPAQYSWFVNGTFQQSTQE--------LFIPNITVNNSGSYTCQAHN 303 E + C +P SW +G+ E L I +++G Y C N Sbjct: 123 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTN 182 Query: 304 SDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSL 363 G + V +TV P F+ ++ V +D+ CE + W + Sbjct: 183 M-VGERESEVAELTVLERPS--FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 239 Query: 364 PVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPS 423 R ++ +D TL + VT D+G Y C +N + + L V P + P Sbjct: 240 LPKSRYEIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEA-SATLTVQ-EPPHFVVKPR 296 Query: 424 YTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQ----------------QHTQELFISNI 467 G ++ C A NP W +G+ T +L I+N+ Sbjct: 297 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 356 Query: 468 TEKNSGLYTCQANNSASGHSRTTVKTIT 495 + G Y CQ N A +T Sbjct: 357 QRSDVGYYICQTLNVAGSIITKAYLEVT 384 Score = 242 bits (616), Expect = 6e-64, Method: Composition-based stats. Identities = 73/378 (19%), Positives = 119/378 (31%), Gaps = 45/378 (11%) Query: 237 PDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQE------------- 283 P P + GE L+C A P W+ G ++ ++ Sbjct: 5 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 64 Query: 284 LFIPNITVN-----NSGSYTCQAHNS-DTGLNRTTVTTITVYAEPPKPFITSNNSNPVED 337 LF I + G Y C A N ++ + + + F + + V Sbjct: 65 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD---DFRQNPSDVMVAV 121 Query: 338 EDAVALTCEPEIQ-NTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQ 396 + + C+P + W + S +++ L + ++D G Y C Sbjct: 122 GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGT 181 Query: 397 NKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLI-DGNI 455 N + S+ L VL P PS + C A +P W DG + Sbjct: 182 NMVGERESEVAELTVLERPS-FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL 240 Query: 456 ------QQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNN 509 + L I +T + G YTC A N + T++ + P + Sbjct: 241 PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASA----TLTVQEPPHFVVKPR 296 Query: 510 SKPVEDKDAVAFTCEPEAQNTTYLWWVNG---------QSLPVSPRLQLSNGNRTLTLFN 560 + V V F CE ++W Q S R +S LT+ N Sbjct: 297 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ-TGDLTITN 355 Query: 561 VTRNDARAYVCGIQNSVS 578 V R+D Y+C N Sbjct: 356 VQRSDVGYYICQTLNVAG 373 Score = 177 bits (447), Expect = 2e-44, Method: Composition-based stats. Identities = 77/378 (20%), Positives = 121/378 (32%), Gaps = 47/378 (12%) Query: 46 AEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNA 105 E + P WYKG + T + P ++ P+ Sbjct: 20 GEPATLNCKAEGRPTPTI--EWYKGGER----------VETDKDDP----RSHRMLLPSG 63 Query: 106 SLLIQNIIQN-----DTGFYTLHVIK--SDLVNEEATGQFRVYPELPKPSISSNNSKPVE 158 SL I+ D G Y + V+ A+ + + + + + + V Sbjct: 64 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQ---NPSDVMVA 120 Query: 159 DKDAVAFTCEPE-TQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCET 217 + C+P + W + S +++ L + ++D Y C Sbjct: 121 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVG 180 Query: 218 QNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFV-NGT 276 N V R S+ L VL P + P N + ++ C A +P W +G Sbjct: 181 TNMVGERESEVAELTVLERP-SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 239 Query: 277 FQQSTQE------LFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSN 330 +S E L I +T + GSYTC A N T+TV EPP + Sbjct: 240 LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG--KAEASATLTVQ-EPPHFVVK-P 295 Query: 331 NSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSL--------PVSPRLQLSNDNRTLTLLS 382 V V CE ++W S P S + LT+ + Sbjct: 296 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 355 Query: 383 VTRNDVGPYECGIQNKLS 400 V R+DVG Y C N Sbjct: 356 VQRSDVGYYICQTLNVAG 373 Score = 151 bits (380), Expect = 1e-36, Method: Composition-based stats. Identities = 57/288 (19%), Positives = 92/288 (31%), Gaps = 33/288 (11%) Query: 415 PDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQ-------------- 460 P PS G +L+C A P W G + + Sbjct: 5 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 64 Query: 461 --ELFISNITEK--NSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDK 516 L I + + + G+Y C A N + A L + + V Sbjct: 65 LFFLRIVHGRKSRPDEGVYVCVARNYLG--EAVSHNASLEVAILRDDFRQNPSDVMVAVG 122 Query: 517 DAVAFTCEPE-AQN-TTYLWWVNGQSLPV-SPRLQLSNGNRTLTLFNVTRNDARAYVCGI 573 + C+P T W +G L R+ + G L + ++DA YVC Sbjct: 123 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGG--KLMITYTRKSDAGKYVCVG 180 Query: 574 QNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRIN--G 631 N V S+ L VL P + P + + + C + +P P WR + Sbjct: 181 TNMVGERESEVAELTVLERPSF-VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 239 Query: 632 IPQQ-----HTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITV 674 +P+ L I K+T + G+Y C N+ S ++ Sbjct: 240 LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE 287 >3V2A-R nrPDB Length = 772 Score = 279 bits (713), Expect = 3e-75, Method: Composition-based stats. Identities = 111/544 (20%), Positives = 192/544 (35%), Gaps = 115/544 (21%) Query: 32 TTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATP 91 +V E + ++W +++++ + TQ Sbjct: 225 DVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQ---- 280 Query: 92 GPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISS 151 SG E+ ++L I + ++D G YT S L+ ++ + RV+ E P + S Sbjct: 281 ----SGSEMKKFLSTLTIDGVTRSDQGLYTCAAS-SGLMTKKNSTFVRVH-EKPFVAFGS 334 Query: 152 NNSKPVEDKDAVAFTCEPETQDATYL--------WWVNNQSLPVSPRLQLSNGNRTLTLF 203 VE A E A YL W+ N +P+ + G+ LT+ Sbjct: 335 GMESLVE-----ATVGERVRIPAKYLGYPPPEIKWYKNG--IPLESNHTIKAGH-VLTIM 386 Query: 204 NVTRNDTASYKCETQNPVSARRSDSVILNVLYGP----DAPTISPLNTSYRSGENLNLSC 259 V+ DT +Y NP+S + V+ V+Y P + ISP++ SY+ G L+C Sbjct: 387 EVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVD-SYQYGTTQTLTC 445 Query: 260 HAASNPPAQY-SWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNS-------------- 304 + PP + W+ +Q + P+ V+ + Y C+ S Sbjct: 446 TVYAIPPPHHIHWY----WQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNK 501 Query: 305 -----DTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAV---------ALTCEPEIQ 350 G N+ TV+T+ + A N V + V +T +P++Q Sbjct: 502 NQFALIEGKNK-TVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQ 560 Query: 351 NT----TYLWWVNNQ-----------------------SLPVSPRLQL------------ 371 T LW ++ PV L Sbjct: 561 PTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNS 620 Query: 372 SNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRP-- 429 +ND + L + + D G Y C Q++ + V + PTI+ + Sbjct: 621 TNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSI 680 Query: 430 GVNLSLSCHAASNPPAQYSWLIDGN---------IQQHTQELFISNITEKNSGLYTCQAN 480 G ++ +SC A+ NPP Q W D ++ + L I + +++ GLYTCQA Sbjct: 681 GESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQAC 740 Query: 481 NSAS 484 + Sbjct: 741 SVLG 744 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 92/449 (20%), Positives = 147/449 (32%), Gaps = 69/449 (15%) Query: 238 DAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQE------------LF 285 D P +S N L + W N + + E L Sbjct: 30 DLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLT 89 Query: 286 IPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVY--AEPPKPFITSNNSNPV---EDEDA 340 IP + N++G+Y C + +V + V P ++ + Sbjct: 90 IPKVIGNDTGAYKC----FYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKT 145 Query: 341 VALTCEPEIQNTTYLWWV---NNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQ- 396 V + C I N + +P R+ + T+ S + G C + Sbjct: 146 VVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGF-TIPSYMISYAGMVFCEAKI 204 Query: 397 NKLSVDHSDPVILNVLYGPDDPTISPSY-TYYRPGVNLSLSCHAAS--NPPAQYSWLIDG 453 N S +++ V Y D +SPS+ G L L+C A + N ++W Sbjct: 205 NDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPS 264 Query: 454 NIQQHT-------------------QELFISNITEKNSGLYTCQANNSASGHSRTTVKTI 494 + QH L I +T + GLYTC A+ SG T Sbjct: 265 SKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAAS---SGLMTKKNSTF 321 Query: 495 TVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQ-----NTTYLWWVNGQSLPVSPRLQL 549 E P + S VE V A+ W+ NG +P+ + Sbjct: 322 VRVHEKPFVAFGSGMESLVEA--TVGERVRIPAKYLGYPPPEIKWYKNG--IPLESNHTI 377 Query: 550 SNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGP----DTPIISPPDSSY 605 G+ LT+ V+ D Y + N +S + V V+Y P + +ISP D SY Sbjct: 378 KAGH-VLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVD-SY 435 Query: 606 LSGANLNLSCHSASNPSPQY---SWRING 631 G L+C + P P + W++ Sbjct: 436 QYGTTQTLTCTVYAIPPPHHIHWYWQLEE 464 Score = 147 bits (371), Expect = 1e-35, Method: Composition-based stats. Identities = 122/673 (18%), Positives = 213/673 (31%), Gaps = 131/673 (19%) Query: 106 SLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPK-PSISSNNS------KPVE 158 +L I +I NDTG Y ++DL + VY + + P I+S + Sbjct: 87 TLTIPKVIGNDTGAYKCFYRETDLAS-----VIYVYVQDYRSPFIASVSDQHGVVYITEN 141 Query: 159 DKDAVAFTCE--PETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCE 216 V C + + + + + T+ + + CE Sbjct: 142 KNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCE 201 Query: 217 TQ-NPVSARRSDSVILNVLYGPDAPTISPLNTS-YRSGENLNLSCHAAS----------- 263 + N S + +++ V Y +SP + GE L L+C A + Sbjct: 202 AKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWE 261 Query: 264 NPPAQYSWFV----------NGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTV 313 P +++ ++ L I +T ++ G YTC A S + + Sbjct: 262 YPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAA--SSGLMTKKNS 319 Query: 314 TTITVYAEPPKPFITSNNSNP-VEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLS 372 T + V+ +P F + S + V + + + W N S Sbjct: 320 TFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHT--I 377 Query: 373 NDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGP----DDPTISPSYTYYR 428 LT++ V+ D G Y + N +S + V+ V+Y P + ISP + Y+ Sbjct: 378 KAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDS-YQ 436 Query: 429 PGVNLSLSCHAASNPPAQ-YSW--------------------------------LIDGNI 455 G +L+C + PP W GN Sbjct: 437 YGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNK 496 Query: 456 QQ--HTQELFISNITEKNS----------GLYTCQANNSASGHSRTTVKTITVSAELPKP 503 + Q I + S LY C+A N R +T E Sbjct: 497 IEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPE---- 552 Query: 504 SISSNNSKPVEDKDAVAFTCEP-EAQNTTYLWWVNG-QSLPVS----------------- 544 I+ ++++V+ C + W+ G Q LP+ Sbjct: 553 -ITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWK 611 Query: 545 -PRLQLSNGNRTLTLF---NVTRNDARAYVCGIQNSVSANRSDPV-TLDVLYGPDTPIIS 599 SN + + N + D YVC Q+ + R V L VL I Sbjct: 612 LNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITG 671 Query: 600 P-PDSSYLSGANLNLSCHSASNPSPQYSWRI-NGIPQQHTQV--------LFIAKITPNN 649 + + G ++ +SC ++ NP PQ W N + + + L I ++ + Sbjct: 672 NLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKED 731 Query: 650 NGTYACFVSNLAT 662 G Y C ++ Sbjct: 732 EGLYTCQACSVLG 744 Score = 135 bits (338), Expect = 9e-32, Method: Composition-based stats. Identities = 95/658 (14%), Positives = 199/658 (30%), Gaps = 125/658 (18%) Query: 140 VYPELPKPSISSNNSK-PVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNR 198 L P +S ++ + TC + W N R++++ + Sbjct: 25 PSVSLDLPRLSIQKDILTIKANTTLQITCRGQRD---LDWLWPNNQSGSEQRVEVTECSD 81 Query: 199 -----TLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNT------ 247 TLT+ V NDT +YKC + + + + V S + Sbjct: 82 GLFCKTLTIPKVIGNDTGAYKCFYR---ETDLASVIYVYVQDYRSPFIASVSDQHGVVYI 138 Query: 248 SYRSGENLNLSCHA----------ASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSY 297 + + + + C A P ++ N S + IP+ ++ +G Sbjct: 139 TENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMV 198 Query: 298 TCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQ------- 350 C+A +D + V ++ ++ + + + L C + Sbjct: 199 FCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDF 258 Query: 351 --NTTYLWWVNNQSLPVSPRLQLSNDN----RTLTLLSVTRNDVGPYECGIQNKLSVDHS 404 + + + + Q ++ TLT+ VTR+D G Y C + L Sbjct: 259 NWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTK-K 317 Query: 405 DPVILNVLYGPDDPTIS--PSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQE- 461 + + V P S S G + + PP + W +G + Sbjct: 318 NSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTI 377 Query: 462 -----LFISNITEKNSGLYTCQANNSASGHSRTTV--KTITVSAELPKPSISSNNSKPVE 514 L I ++E+++G YT N S ++ V + V ++ + S+ S + Sbjct: 378 KAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDS-YQ 436 Query: 515 DKDAVAFTCEPEAQNTTY----------------------------------LWWVNGQS 540 TC A + + G Sbjct: 437 YGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNK 496 Query: 541 LPVSPRL--QLSNGNRTLTLFNVTRND-ARAYVCGIQNSVSANRSDPVTLDVLYGPDTPI 597 + V+ + N+T++ + + + Y C N V + I Sbjct: 497 IEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGER---VISFHVTRGPEI 553 Query: 598 ISPPDSSYLSGANLNLSCHSASN-------------PSPQYS--------------WRIN 630 PD +++L C + + P P + W++N Sbjct: 554 TLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLN 613 Query: 631 GIPQQHTQ----VLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLS 684 ++ ++ + + + G Y C + T + + +V+ +TV +P ++ Sbjct: 614 ATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTV-LERVAPTIT 670 Score = 99.6 bits (246), Expect = 4e-21, Method: Composition-based stats. Identities = 73/413 (17%), Positives = 127/413 (30%), Gaps = 77/413 (18%) Query: 70 GERVDGNRQIIGYVIGT-QQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSD 128 GERV + +GY + G I L I + + DTG YT+ + Sbjct: 345 GERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNP- 403 Query: 129 LVNEEATGQFRVYPELPKPSISSNNSKPVED---KDAVAFTCEPETQDATYL---WWVNN 182 + E+ + + +P + PV+ TC + +W Sbjct: 404 ISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLE 463 Query: 183 QSLPVSPRLQLSNGNRT--LTLFNVTRNDTAS---------------------------- 212 + P +S N +V + Sbjct: 464 EECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAAN 523 Query: 213 ----YKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASN---- 264 YKCE N V R + +V GP+ T+ P E+++L C A + Sbjct: 524 VSALYKCEAVNKVG-RGERVISFHVTRGPE-ITLQPDMQPTEQ-ESVSLWCTADRSTFEN 580 Query: 265 ------------------PPA-----QYSWFVNGT-FQQSTQELFI---PNITVNNSGSY 297 P W +N T F ST ++ I N ++ + G Y Sbjct: 581 LTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDY 640 Query: 298 TCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWW 357 C A + T V +TV + + +++ ++C + W Sbjct: 641 VCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMW 700 Query: 358 VNN-QSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVIL 409 + ++L + L + NR LT+ V + D G Y C + L + + Sbjct: 701 FKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFI 753 Score = 77.3 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 69/410 (16%), Positives = 136/410 (33%), Gaps = 46/410 (11%) Query: 305 DTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLP 364 +V +V + P+ I + ++ + +TC + ++ +LW N Sbjct: 14 CVETRAASVGLPSVSLDLPRLSIQ-KDILTIKANTTLQITCRGQ-RDLDWLWPNNQSGSE 71 Query: 365 VSPRLQLSNDN---RTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS 421 + +D +TLT+ V ND G Y+C + D + + + V S Sbjct: 72 QRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYR---ETDLASVIYVYVQDYRSPFIAS 128 Query: 422 PS------YTYYRPGVNLSLSCHAA-SNPP-------AQYSWLIDGNIQQHTQE--LFIS 465 S Y + + C + SN + ++ DGN + I Sbjct: 129 VSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIP 188 Query: 466 NITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEP 525 + +G+ C+A + + + V + +S ++ + + + C Sbjct: 189 SYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTA 248 Query: 526 EAQNTTYLWWVNGQSLPVSPRLQLSNGN-------------RTLTLFNVTRNDARAYVCG 572 + + + +L N + TLT+ VTR+D Y C Sbjct: 249 RTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCA 308 Query: 573 IQNSVSANRSDPVTLDVLYGPDTPIISPPDSSY--LSGANLNLSCHSASNPSPQYSWRIN 630 + + ++ V P S +S G + + P P+ W N Sbjct: 309 ASSGLMTKKNSTFV-RVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKN 367 Query: 631 GIPQQHTQV------LFIAKITPNNNGTYACFVSNLATGRNNSIVKSITV 674 GIP + L I +++ + G Y ++N + S V S+ V Sbjct: 368 GIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVV 417 Score = 47.6 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 49/326 (15%), Positives = 93/326 (28%), Gaps = 53/326 (16%) Query: 416 DDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLID--GNIQQ----------HTQELF 463 D P +S N +L + W + G+ Q+ + L Sbjct: 30 DLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLT 89 Query: 464 ISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNS------KPVEDKD 517 I + ++G Y C + + P I+S + Sbjct: 90 IPKVIGNDTGAYKCFYR-----ETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNK 144 Query: 518 AVAFTC--EPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQ- 574 V C N + + + + T+ + + A C + Sbjct: 145 TVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKI 204 Query: 575 NSVSANRSDPVTLDVLYGPDTPIISPP-DSSYLSGANLNLSCHSAS--NPSPQYSWRING 631 N S + + V Y ++SP G L L+C + + N ++W Sbjct: 205 NDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPS 264 Query: 632 IPQQHTQ-------------------VLFIAKITPNNNGTYACFVSNLATGRNNSIVKSI 672 QH + L I +T ++ G Y C S+ + NS + Sbjct: 265 SKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRV 324 Query: 673 TVSASGTSPGLSAGATVGIMIGVLVG 698 P ++ G+ + ++ VG Sbjct: 325 HE-----KPFVAFGSGMESLVEATVG 345 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 19/111 (17%), Positives = 31/111 (27%), Gaps = 20/111 (18%) Query: 16 QRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDG 75 +R + L T +E+ ++ E EV P W+K Sbjct: 651 KRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIM--WFKDNETLV 708 Query: 76 NRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIK 126 SG + N +L I+ + + D G YT Sbjct: 709 ED------------------SGIVLKDGNRNLTIRRVRKEDEGLYTCQACS 741 >5Z5K-A nrPDB Length = 380 Score = 260 bits (664), Expect = 1e-69, Method: Composition-based stats. Identities = 76/331 (22%), Positives = 125/331 (37%), Gaps = 37/331 (11%) Query: 97 GREIIYPNASLLIQNIIQN-----DTGFYTLHVIKSD---LVNEEATGQFRVYPELPKPS 148 R+ PN SLLIQNI+ + D G Y D +++ A +V P Sbjct: 49 DRKQQLPNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTA----KVMVAGPLRF 104 Query: 149 ISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQ----SLPVSPRLQLSNGNRTLTLFN 204 +S S D V CE + W NQ +P R+ + L + Sbjct: 105 LSQTESITAFMGDTVLLKCEVIGDPMPTIHWQKNQQDLNPIPGDSRVVVLPS-GALQISR 163 Query: 205 VTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTI-----SPLNTSYRSGENLNLSC 259 + D+ Y+C +NP S R + + +L P P N G++ L C Sbjct: 164 LQPGDSGVYRCSARNPASTRTGNEAEVRILSDPGLHRQLYFLQRPSNVIAIEGKDAVLEC 223 Query: 260 HAASNPPAQYSWFVNGTFQQSTQE---------LFIPNITVNNSGSYTCQAHNSDTGLNR 310 + PP ++W Q + L I N+T ++SG+YTC + ++ Sbjct: 224 CVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNENISA 283 Query: 311 TTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPV-SPRL 369 + T+ V PP +N E D + C + + W+ N + + S Sbjct: 284 SAELTVLV---PPWFLNHPSNLYAYESMD-IEFECAVSGKPVPTVNWMKNGDVVIPSDYF 339 Query: 370 QLSNDNRTLTLLSVTRNDVGPYECGIQNKLS 400 Q+ L +L V ++D G Y+C +N+ Sbjct: 340 QIV-GGSNLRILGVVKSDEGFYQCVAENEAG 369 Score = 223 bits (568), Expect = 2e-58, Method: Composition-based stats. Identities = 89/382 (23%), Positives = 129/382 (33%), Gaps = 44/382 (11%) Query: 243 SPLNTSYRSGENLNLSCHAASNP-PAQYSWFVNGTF----------QQSTQELFIPNITV 291 P + G N+ L+C A S+ W +G Q L I NI Sbjct: 7 EPSDAVTMRGGNVLLNCSAESDRGVPVIKWKKDGLILALGMDDRKQQLPNGSLLIQNILH 66 Query: 292 N-----NSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCE 346 + + G Y C+A D+G T V P F++ S D V L CE Sbjct: 67 SRHHKPDEGLYQCEASLGDSG--SIISRTAKVMVAGPLRFLSQTESITAFMGDTVLLKCE 124 Query: 347 PEIQNTTYLWWVNNQSL---PVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDH 403 + W NQ + + L + + D G Y C +N S Sbjct: 125 VIGDPMPTIHWQKNQQDLNPIPGDSRVVVLPSGALQISRLQPGDSGVYRCSARNPASTRT 184 Query: 404 SDPVILNVLYGPDD-----PTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQH 458 + + +L P PS G + L C + PP ++WL + Q Sbjct: 185 GNEAEVRILSDPGLHRQLYFLQRPSNVIAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQL 244 Query: 459 TQE---------LFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSA-ELPKPSISSN 508 + L ISN+T+ +SG YTC S + T+ V L PS Sbjct: 245 RSKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNENISASAELTVLVPPWFLNHPS---- 300 Query: 509 NSKPVEDKDAVAFTCEPEAQN-TTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDAR 567 N E D + F C + T W NG + S Q+ G+ L + V ++D Sbjct: 301 NLYAYESMD-IEFECAVSGKPVPTVNWMKNGDVVIPSDYFQIVGGS-NLRILGVVKSDEG 358 Query: 568 AYVCGIQNSVSANRSDPVTLDV 589 Y C +N N L V Sbjct: 359 FYQCVAENEAG-NAQSSAQLIV 379 Score = 194 bits (491), Expect = 2e-49, Method: Composition-based stats. Identities = 70/381 (18%), Positives = 122/381 (32%), Gaps = 39/381 (10%) Query: 326 FITSNNSNPVEDEDAVALTCEPEI-QNTTYLWWVNNQSL----PVSPRLQLSNDNRTLTL 380 F++ + V L C E + + W + + + QL N +L + Sbjct: 4 FVSEPSDAVTMRGGNVLLNCSAESDRGVPVIKWKKDGLILALGMDDRKQQLPN--GSLLI 61 Query: 381 LSV-----TRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSL 435 ++ + D G Y+C S ++ GP G + L Sbjct: 62 QNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVMVAGPLRFLSQTESITAFMGDTVLL 121 Query: 436 SCHAASNPPAQYSWLIDGN-----------IQQHTQELFISNITEKNSGLYTCQANNSAS 484 C +P W + + + L IS + +SG+Y C A N AS Sbjct: 122 KCEVIGDPMPTIHWQKNQQDLNPIPGDSRVVVLPSGALQISRLQPGDSGVYRCSARNPAS 181 Query: 485 GHS-RTTVKTITVSAELPKPSI--SSNNSKPVEDKDAVAFTCEPEAQNTT-YLWWVNGQS 540 + I L + ++ + C + W + Sbjct: 182 TRTGNEAEVRILSDPGLHRQLYFLQRPSNVIAIEGKDAVLECCVSGYPPPSFTWLRGEEV 241 Query: 541 LPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISP 600 + + + G L + NVT +D+ Y C + N S L VL P ++ Sbjct: 242 IQLRSKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKN-ENISASAELTVLVPP--WFLNH 298 Query: 601 PDSSYLSG-ANLNLSCHSASNPSPQYSWRING---IPQQHTQV-----LFIAKITPNNNG 651 P + Y ++ C + P P +W NG IP + Q+ L I + ++ G Sbjct: 299 PSNLYAYESMDIEFECAVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEG 358 Query: 652 TYACFVSNLATGRNNSIVKSI 672 Y C N A +S + Sbjct: 359 FYQCVAENEAGNAQSSAQLIV 379 Score = 88.8 bits (218), Expect = 7e-18, Method: Composition-based stats. Identities = 36/208 (17%), Positives = 68/208 (32%), Gaps = 31/208 (14%) Query: 20 LTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQI 79 L L P + + + V P F +W +GE V R Sbjct: 198 LHRQLYFLQRPSNVIAIE--------GKDAVLECCVSGYPPPSF--TWLRGEEVIQLRSK 247 Query: 80 IGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFR 139 ++G ++LLI N+ +D+G YT V NE + Sbjct: 248 KYSLLGG------------------SNLLISNVTDDDSGTYTCVVTYK---NENISASAE 286 Query: 140 VYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRT 199 + +P ++ ++ + + F C + + W+ N + + G Sbjct: 287 LTVLVPPWFLNHPSNLYAYESMDIEFECAVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSN 346 Query: 200 LTLFNVTRNDTASYKCETQNPVSARRSD 227 L + V ++D Y+C +N +S Sbjct: 347 LRILGVVKSDEGFYQCVAENEAGNAQSS 374 >3JXA-A nrPDB Length = 383 Score = 254 bits (649), Expect = 7e-68, Method: Composition-based stats. Identities = 94/384 (24%), Positives = 143/384 (37%), Gaps = 44/384 (11%) Query: 240 PTISPLNTSY---RSGENLNLSCHAASNPPAQYSWFVNGT-------FQQSTQE--LFIP 287 P + + + + LSC NP W +NGT F+ S + L I Sbjct: 7 FVQEPSHVMFPLDSEEKKVKLSCEVKGNPKPHIRWKLNGTDVDIGMDFRYSVVDGSLLIN 66 Query: 288 NITV-NNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCE 346 N ++G+Y C A NS + Y E K S S V + L C Sbjct: 67 NPNKTQDAGTYQCIATNSFGTIVSREAKLQFAYLENFKTRTRSTVS--VRRGQGMVLLCG 124 Query: 347 PE--IQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHS 404 P +Y W N R +S + L + V ++DVG Y C + N ++ +H Sbjct: 125 PPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVT-NHK 183 Query: 405 -----DPVIL--NVLYGPDDPTISPSYTYYRP---GVNLSLSCHAASNPPAQYSWLI-DG 453 P+IL + + G +P I + P G + L C A NP W DG Sbjct: 184 VLGPPTPLILRNDGVMGEYEPKIEVQFPETVPAEKGTTVKLECFALGNPVPTILWRRADG 243 Query: 454 NI-------QQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSIS 506 + L I N ++++G Y C A NS +T A+ + Sbjct: 244 KPIARKARRHKSNGILEIPNFQQEDAGSYECVAENSRG--KNVAKGQLTFYAQPNW--VQ 299 Query: 507 SNNSKPVEDKDAVAFTCEPEAQN-TTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRND 565 N V +++V + C+ + TY W NG L R+Q+ G +T+ N++ D Sbjct: 300 IINDIHVAMEESVFWECKANGRPKPTYRWLKNGDPLLTRDRIQIEQGTLNITIVNLS--D 357 Query: 566 ARAYVCGIQNSVSANRSDPVTLDV 589 A Y C +N S L V Sbjct: 358 AGMYQCVAENKHGVIFSS-AELSV 380 Score = 213 bits (541), Expect = 3e-55, Method: Composition-based stats. Identities = 82/325 (25%), Positives = 120/325 (36%), Gaps = 34/325 (10%) Query: 104 NASLLIQNIIQ-NDTGFYTLHVIKS--DLVNEEATGQFRVYPELPKPSISSNNSKPVEDK 160 + SLLI N + D G Y S +V+ EA QF Y E K S S V Sbjct: 60 DGSLLINNPNKTQDAGTYQCIATNSFGTIVSREAKLQF-AYLENFKTRTRSTVS--VRRG 116 Query: 161 DAVAFTCEP--ETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ 218 + C P + + +Y W N R +S L + V ++D +Y C Sbjct: 117 QGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVT 176 Query: 219 NPVSAR-----------RSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPA 267 N V+ R+D V+ Y P P G + L C A NP Sbjct: 177 NTVTNHKVLGPPTPLILRNDGVMGE--YEPKIEVQFPETVPAEKGTTVKLECFALGNPVP 234 Query: 268 QYSWFV-NGTFQQSTQE-------LFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVY 319 W +G L IPN ++GSY C A NS +T Y Sbjct: 235 TILWRRADGKPIARKARRHKSNGILEIPNFQQEDAGSYECVAENSRGKNVAKGQ--LTFY 292 Query: 320 AEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLT 379 A+P I ++ +E ++V C+ + W+ N P+ R ++ + TL Sbjct: 293 AQPNWVQIINDIHVAME--ESVFWECKANGRPKPTYRWLKNGD-PLLTRDRIQIEQGTLN 349 Query: 380 LLSVTRNDVGPYECGIQNKLSVDHS 404 + V +D G Y+C +NK V S Sbjct: 350 ITIVNLSDAGMYQCVAENKHGVIFS 374 Score = 205 bits (520), Expect = 8e-53, Method: Composition-based stats. Identities = 78/367 (21%), Positives = 128/367 (34%), Gaps = 38/367 (10%) Query: 337 DEDAVALTCEPEIQNTTYLWWVNNQSLP-VSPRLQLSNDNRTLTLLSVTR-NDVGPYECG 394 +E V L+CE + ++ W N + + + S + +L + + + D G Y+C Sbjct: 21 EEKKVKLSCEVKGNPKPHIRWKLNGTDVDIGMDFRYSVVDGSLLINNPNKTQDAGTYQCI 80 Query: 395 IQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPA-----QYSW 449 N S L Y + T + S R G + L C PP Y+W Sbjct: 81 ATNSFGTIVSREAKLQFAYLENFKTRTRSTVSVRRGQGMVLLC----GPPPHSGELSYAW 136 Query: 450 LIDGNIQ---------QHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAE- 499 + + Q T L+I+ + + + G YTC N+ + H T + Sbjct: 137 IFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRND 196 Query: 500 ------LPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGN 553 PK + + P E V C + W P++ + + N Sbjct: 197 GVMGEYEPKIEVQFPETVPAEKGTTVKLECFALGNPVPTILWRRADGKPIARKARRHKSN 256 Query: 554 RTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPD-TPIISPPDSSYLSGANLN 612 L + N + DA +Y C +NS N + L P+ II+ D ++ Sbjct: 257 GILEIPNFQQEDAGSYECVAENSRGKNVAKG-QLTFYAQPNWVQIIN--DIHVAMEESVF 313 Query: 613 LSCHSASNPSPQYSWRINGIP-------QQHTQVLFIAKITPNNNGTYACFVSNLATGRN 665 C + P P Y W NG P Q L I + ++ G Y C N Sbjct: 314 WECKANGRPKPTYRWLKNGDPLLTRDRIQIEQGTLNITIVNLSDAGMYQCVAENKHGVIF 373 Query: 666 NSIVKSI 672 +S S+ Sbjct: 374 SSAELSV 380 Score = 179 bits (454), Expect = 3e-45, Method: Composition-based stats. Identities = 74/385 (19%), Positives = 133/385 (34%), Gaps = 40/385 (10%) Query: 140 VYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYL-WWVNNQSLPVSPRLQLSNGNR 198 V+ + P + +S ++ V +CE + ++ W +N + + + S + Sbjct: 6 VFVQEPSHVMFPLDS----EEKKVKLSCEVKGNPKPHIRWKLNGTDVDIGMDFRYSVVDG 61 Query: 199 TLTLFNVTRN-DTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNL 257 +L + N + D +Y+C N S L Y + T + S R G+ + L Sbjct: 62 SLLINNPNKTQDAGTYQCIATNSFGTIVSREAKLQFAYLENFKTRTRSTVSVRRGQGMVL 121 Query: 258 SCHAASNPPAQ-----YSWFVNGTFQ---------QSTQELFIPNITVNNSGSYTCQAHN 303 C PP Y+W N Q T L+I + ++ G+YTC N Sbjct: 122 LC----GPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTN 177 Query: 304 SDTGLNRTTVTTITVYAE-------PPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLW 356 + T T + PK + + P E V L C + Sbjct: 178 TVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPAEKGTTVKLECFALGNPVPTIL 237 Query: 357 WVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPD 416 W P++ + + N L + + + D G YEC +N + + Y Sbjct: 238 WRRADGKPIARKARRHKSNGILEIPNFQQEDAGSYECVAENSRGKNVAKG--QLTFYAQP 295 Query: 417 DPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDG-------NIQQHTQELFISNITE 469 + + + ++ C A P Y WL +G IQ L I+ + Sbjct: 296 NWVQIINDIHVAMEESVFWECKANGRPKPTYRWLKNGDPLLTRDRIQIEQGTLNITIVNL 355 Query: 470 KNSGLYTCQANNSASGHSRTTVKTI 494 ++G+Y C A N + ++ Sbjct: 356 SDAGMYQCVAENKHGVIFSSAELSV 380 Score = 120 bits (300), Expect = 2e-27, Method: Composition-based stats. Identities = 47/243 (19%), Positives = 82/243 (33%), Gaps = 19/243 (7%) Query: 93 PAYSG--REIIYPNASLLIQNIIQNDTGFYTLHVIKS----DLVNEEATGQFR---VYPE 143 P+Y R + +L I + ++D G YT V + ++ R V E Sbjct: 142 PSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGE 201 Query: 144 -LPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTL 202 PK + + P E V C + W P++ + + N L + Sbjct: 202 YEPKIEVQFPETVPAEKGTTVKLECFALGNPVPTILWRRADGKPIARKARRHKSNGILEI 261 Query: 203 FNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAA 262 N + D SY+C +N + L P+ I + E++ C A Sbjct: 262 PNFQQEDAGSYECVAENSRGKNVAK-GQLTFYAQPNWVQI-INDIHVAMEESVFWECKAN 319 Query: 263 SNPPAQYSWFVNGTFQQSTQ-------ELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTT 315 P Y W NG + L I + ++++G Y C A N + + + Sbjct: 320 GRPKPTYRWLKNGDPLLTRDRIQIEQGTLNITIVNLSDAGMYQCVAENKHGVIFSSAELS 379 Query: 316 ITV 318 + Sbjct: 380 VIA 382 Score = 77.3 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 34/138 (24%), Positives = 52/138 (37%), Gaps = 6/138 (4%) Query: 83 VIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYP 142 I ++A P N L I N Q D G Y S N A GQ Y Sbjct: 235 TILWRRADGKPIARKARRHKSNGILEIPNFQQEDAGSYECVAENSRGKNV-AKGQLTFYA 293 Query: 143 ELPKPSISSNNSKPVEDKDAVAFTCEPETQDAT-YLWWVNNQSLPVSPRLQLSNGNRTLT 201 + + N V +++V + C+ + Y W N L R+Q+ G +T Sbjct: 294 Q--PNWVQIINDIHVAMEESVFWECKANGRPKPTYRWLKNGDPLLTRDRIQIEQGTLNIT 351 Query: 202 LFNVTRNDTASYKCETQN 219 + N+ +D Y+C +N Sbjct: 352 IVNL--SDAGMYQCVAEN 367 Score = 52.2 bits (123), Expect = 8e-07, Method: Composition-based stats. Identities = 19/85 (22%), Positives = 28/85 (32%), Gaps = 13/85 (15%) Query: 589 VLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQ----------HTQ 638 V + ++ P DS + LSC NP P W++NG Sbjct: 6 VFVQEPSHVMFPLDS---EEKKVKLSCEVKGNPKPHIRWKLNGTDVDIGMDFRYSVVDGS 62 Query: 639 VLFIAKITPNNNGTYACFVSNLATG 663 +L + GTY C +N Sbjct: 63 LLINNPNKTQDAGTYQCIATNSFGT 87 Score = 35.3 bits (79), Expect = 0.10, Method: Composition-based stats. Identities = 18/112 (16%), Positives = 30/112 (26%), Gaps = 23/112 (20%) Query: 20 LTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQI 79 + LTF+ P ++ + +VA + V + Y W K Sbjct: 284 VAKGQLTFYAQPNWVQIIND---IHVAMEESVFWECKANGRPKPTYRWLKNG-------- 332 Query: 80 IGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVN 131 P + I +L I + +D G Y V Sbjct: 333 ------------DPLLTRDRIQIEQGTLNITIVNLSDAGMYQCVAENKHGVI 372 >4FOM-A nrPDB Length = 308 Score = 190 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 62/300 (20%), Positives = 102/300 (34%), Gaps = 46/300 (15%) Query: 418 PTISPSYTYYRPGVNLSLSCHAASNPPAQ-YSW-LIDGNIQQ------------------ 457 P I + G N+SL C N SW I G Q Sbjct: 2 PIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQYGFSVQGEYQ 61 Query: 458 ----------HTQELFISNITEKNSGLYTCQA-NNSASGHSRTTVKTITVSAELPKPSIS 506 + + + NI +SG Y C+A +T T+TV E I Sbjct: 62 GRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSST--TVTVLVEPTVSLIK 119 Query: 507 SNNSKPVEDKDAVAFTC-EPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTL----TLFNV 561 +S + VA C + ++ W S N T+ LF Sbjct: 120 GPDSLIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPT 179 Query: 562 TRNDARAYVCGIQNS-VSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASN 620 R C +++ + + LD+ Y P+ + + ++ +NL C++ +N Sbjct: 180 RFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADAN 239 Query: 621 PSPQYS-WRI------NGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSIT 673 P P S W +G+ + F+ +T N +G Y C V+N R++ V I+ Sbjct: 240 PPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYIS 299 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 109/302 (36%), Gaps = 44/302 (14%) Query: 240 PTISPLNTSYRSGENLNLSCHAASNPP---------------------AQYSWFVNGTFQ 278 P I + + G+N++L C N QY + V G +Q Sbjct: 2 PIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQYGFSVQGEYQ 61 Query: 279 QS---------TQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITS 329 + + NI ++SG Y C+A G N + TT+TV EP I Sbjct: 62 GRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLG-NAQSSTTVTVLVEPTVSLIKG 120 Query: 330 NNSNPVEDEDAVALTCE-PEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTL---TLLSVTR 385 +S + VA C + ++ W + S N+ T+ L TR Sbjct: 121 PDSLIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTR 180 Query: 386 NDVG-PYECGIQN-KLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNP 443 G C +++ L D IL++ Y P+ ++ ++L C+A +NP Sbjct: 181 FARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANP 240 Query: 444 PA---QYSWL----IDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITV 496 P +S L DG + F+ +T SG+Y C+ NS S V I+ Sbjct: 241 PPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISD 300 Query: 497 SA 498 Sbjct: 301 PP 302 Score = 78.4 bits (191), Expect = 9e-15, Method: Composition-based stats. Identities = 60/291 (20%), Positives = 107/291 (36%), Gaps = 24/291 (8%) Query: 46 AEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPA-YSGREIIYP- 103 + + L+ + + + SW E++ G V Q Y GR + Sbjct: 14 GKNVSLKCLIE-VNETITQISW---EKIHGKSSQTVAVHHPQYGFSVQGEYQGRVLFKNY 69 Query: 104 ---NASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDK 160 +A++ + NI +D+G Y + L N +++ V E I +S Sbjct: 70 SLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGN 129 Query: 161 DAVAFTCE-PETQDATYLWWVNNQSLPVSPRLQLSNGNRTL----TLFNVTRNDTASYKC 215 + VA C + ++ W + S N T+ LF C Sbjct: 130 ETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFARGRRITC 189 Query: 216 ETQNPVSARRSD-SVILNVLYGPDAPTISPLNTSYRSGEN-LNLSCHAASNPPAQYS-WF 272 ++P + S IL++ Y P+ +++ + ++ G +NL C+A +NPP S W Sbjct: 190 VVKHPALEKDIRYSFILDIQYAPEV-SVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWS 248 Query: 273 V------NGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTIT 317 +G F+ +T N SG Y C+ NS + V I+ Sbjct: 249 RLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYIS 299 >3V6B-R nrPDB Length = 424 Score = 187 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 71/343 (20%), Positives = 124/343 (36%), Gaps = 56/343 (16%) Query: 32 TTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATP 91 +V E + ++W +++++ + TQ Sbjct: 95 DVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQ---- 150 Query: 92 GPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISS 151 SG E+ ++L I + ++D G YT S L+ ++ + RV+ E P + S Sbjct: 151 ----SGSEMKKFLSTLTIDGVTRSDQGLYTCAAS-SGLMTKKNSTFVRVH-EKPFVAFGS 204 Query: 152 NNSKPVEDKDAVAFTCEPETQDATYL--------WWVNNQSLPVSPRLQLSNGNRTLTLF 203 VE A E A YL W+ N +P+ + G+ LT+ Sbjct: 205 GMESLVE-----ATVGERVRIPAKYLGYPPPEIKWYKNG--IPLESNHTIKAGH-VLTIM 256 Query: 204 NVTRNDTASYKCETQNPVSARRSDSVILNVLYGP----DAPTISPLNTSYRSGENLNLSC 259 V+ DT +Y NP+S + V+ V+Y P + ISP++ SY+ G L+C Sbjct: 257 EVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVD-SYQYGTTQTLTC 315 Query: 260 HAASNPPAQY-SWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNS-------------- 304 + PP + W+ +Q + P+ V+ + Y C+ S Sbjct: 316 TVYAIPPPHHIHWY----WQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNK 371 Query: 305 -----DTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVA 342 G N+ TV+T+ + A N V + V Sbjct: 372 NQFALIEGKNK-TVSTLVIQAANVSALYKCEAVNKVGRGERVI 413 Score = 177 bits (447), Expect = 2e-44, Method: Composition-based stats. Identities = 74/334 (22%), Positives = 115/334 (34%), Gaps = 48/334 (14%) Query: 336 EDEDAVALTCEPEIQNTTYLWWV---NNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYE 392 V + C I N + +P R+ + T+ S + G Sbjct: 11 NKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGF-TIPSYMISYAGMVF 69 Query: 393 CGIQ-NKLSVDHSDPVILNVLYGPDDPTISPSY-TYYRPGVNLSLSCHAAS--NPPAQYS 448 C + N S +++ V Y D +SPS+ G L L+C A + N ++ Sbjct: 70 CEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFN 129 Query: 449 WLIDGNIQQHT-------------------QELFISNITEKNSGLYTCQANNSASGHSRT 489 W + QH L I +T + GLYTC A+ SG Sbjct: 130 WEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAAS---SGLMTK 186 Query: 490 TVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQ-----NTTYLWWVNGQSLPVS 544 T E P + S VE V A+ W+ NG +P+ Sbjct: 187 KNSTFVRVHEKPFVAFGSGMESLVEA--TVGERVRIPAKYLGYPPPEIKWYKNG--IPLE 242 Query: 545 PRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGP----DTPIISP 600 + G+ LT+ V+ D Y + N +S + V V+Y P + +ISP Sbjct: 243 SNHTIKAGH-VLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISP 301 Query: 601 PDSSYLSGANLNLSCHSASNPSPQY---SWRING 631 D SY G L+C + P P + W++ Sbjct: 302 VD-SYQYGTTQTLTCTVYAIPPPHHIHWYWQLEE 334 Score = 99.2 bits (245), Expect = 5e-21, Method: Composition-based stats. Identities = 51/315 (16%), Positives = 103/315 (32%), Gaps = 30/315 (9%) Query: 267 AQYSWFVNGTFQ--QSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPK 324 + + +G S + IP+ ++ +G C+A +D + V Sbjct: 36 PEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYD 95 Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQ---------NTTYLWWVNNQSLPVSPRLQLSNDN 375 ++ ++ + + + L C + + + + + Q ++ Sbjct: 96 VVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEM 155 Query: 376 ----RTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYTYYRP 429 TLT+ VTR+D G Y C + L + + V P S S Sbjct: 156 KKFLSTLTIDGVTRSDQGLYTCAASSGLMTK-KNSTFVRVHEKPFVAFGSGMESLVEATV 214 Query: 430 GVNLSLSCHAASNPPAQYSWLIDGNIQQHTQE------LFISNITEKNSGLYTCQANNSA 483 G + + PP + W +G + L I ++E+++G YT N Sbjct: 215 GERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPI 274 Query: 484 SGHSRTTV--KTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYL---WWVNG 538 S ++ V + V ++ + S+ S + TC A + +W Sbjct: 275 SKEKQSHVVSLVVYVPPQIGEKSLISPVDS-YQYGTTQTLTCTVYAIPPPHHIHWYWQLE 333 Query: 539 QSLPVSPRLQLSNGN 553 + P +S N Sbjct: 334 EECANEPSQAVSVTN 348 Score = 67.3 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 42/253 (16%), Positives = 84/253 (33%), Gaps = 24/253 (9%) Query: 445 AQYSWLIDGNIQQHTQE--LFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPK 502 + ++ DGN + I + +G+ C+A + + + V + Sbjct: 36 PEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYD 95 Query: 503 PSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGN--------- 553 +S ++ + + + C + + + +L N + Sbjct: 96 VVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEM 155 Query: 554 ----RTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSY--LS 607 TLT+ VTR+D Y C + + ++ V P S +S Sbjct: 156 KKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFV-RVHEKPFVAFGSGMESLVEATV 214 Query: 608 GANLNLSCHSASNPSPQYSWRINGIPQQHTQV------LFIAKITPNNNGTYACFVSNLA 661 G + + P P+ W NGIP + L I +++ + G Y ++N Sbjct: 215 GERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPI 274 Query: 662 TGRNNSIVKSITV 674 + S V S+ V Sbjct: 275 SKEKQSHVVSLVV 287 Score = 37.6 bits (85), Expect = 0.018, Method: Composition-based stats. Identities = 33/213 (15%), Positives = 63/213 (29%), Gaps = 30/213 (14%) Query: 511 KPVEDKDAVAFTC--EPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARA 568 V C N + + + + T+ + + A Sbjct: 8 ITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGM 67 Query: 569 YVCGIQ-NSVSANRSDPVTLDVLYGPDTPIISPP-DSSYLSGANLNLSCHSAS--NPSPQ 624 C + N S + + V Y ++SP G L L+C + + N Sbjct: 68 VFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGID 127 Query: 625 YSWRINGIPQQHTQ-------------------VLFIAKITPNNNGTYACFVSNLATGRN 665 ++W QH + L I +T ++ G Y C S+ + Sbjct: 128 FNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKK 187 Query: 666 NSIVKSITVSASGTSPGLSAGATVGIMIGVLVG 698 NS + P ++ G+ + ++ VG Sbjct: 188 NSTFVRVHE-----KPFVAFGSGMESLVEATVG 215 >6DLF-A nrPDB Length = 306 Score = 186 bits (471), Expect = 3e-47, Method: Composition-based stats. Identities = 58/273 (21%), Positives = 101/273 (36%), Gaps = 42/273 (15%) Query: 243 SPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTF-------------------QQSTQE 283 + N + R GE+ L C N + +W T Q+ Sbjct: 19 AMDNVTVRQGESATLRC-TIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYS 77 Query: 284 LFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVAL 343 + I N+ V + G YTC + +T+ + V P I+S+ S + + + ++L Sbjct: 78 IEIQNVDVYDEGPYTCSVQTDNHP--KTSRVHLIVQVSPKIVEISSDIS--INEGNNISL 133 Query: 344 TCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDH 403 TC + + W + V +++ L + +TR G YEC N ++ Sbjct: 134 TCIATGRPEPTVTWRHISPKAV----GFVSEDEYLEIQGITREQSGDYECSASNDVAAPV 189 Query: 404 SDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLID------GNIQQ 457 V + V Y P + G +L C A++ P A++ W D G Sbjct: 190 VRRVKVTVNYPPYISEAKGTGVP--VGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGV 247 Query: 458 HTQ------ELFISNITEKNSGLYTCQANNSAS 484 + +L N++E + G YTC A+N Sbjct: 248 KVENRPFLSKLIFFNVSEHDYGNYTCVASNKLG 280 Score = 164 bits (415), Expect = 9e-41, Method: Composition-based stats. Identities = 44/222 (19%), Positives = 87/222 (39%), Gaps = 23/222 (10%) Query: 106 SLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAF 165 S+ IQN+ D G YT V N T + + ++ + ++ + + + ++ Sbjct: 77 SIEIQNVDVYDEGPYTCSV---QTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISL 133 Query: 166 TCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARR 225 TC + + W + + + + L + +TR + Y+C N V+A Sbjct: 134 TCIATGRPEPTVTWRHISP----KAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPV 189 Query: 226 SDSVILNVLYGPDAPTISPLNTSYRS-GENLNLSCHAASNPPAQYSWFVNGTFQQSTQ-- 282 V + V Y P IS + G+ L C A++ P A++ W+ + + Sbjct: 190 VRRVKVTVNY---PPYISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG 246 Query: 283 ----------ELFIPNITVNNSGSYTCQAHNSDTGLNRTTVT 314 +L N++ ++ G+YTC A N N + + Sbjct: 247 VKVENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIML 288 Score = 108 bits (268), Expect = 1e-23, Method: Composition-based stats. Identities = 45/200 (22%), Positives = 76/200 (38%), Gaps = 20/200 (10%) Query: 509 NSKPVEDKDAVAFTCEPEAQNTTYLW-------WVNGQSLPVSPRLQLSNGNRT---LTL 558 ++ V ++ C + + T W + + PR+ L + +T + + Sbjct: 21 DNVTVRQGESATLRCTIDNRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIEI 80 Query: 559 FNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSA 618 NV D Y C +Q ++ V L V P IS D S G N++L+C + Sbjct: 81 QNVDVYDEGPYTCSVQTDNHP-KTSRVHLIVQVSPKIVEIS-SDISINEGNNISLTCIAT 138 Query: 619 SNPSPQYSWRINGIPQ----QHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITV 674 P P +WR + L I IT +G Y C SN +V+ + V Sbjct: 139 GRPEPTVTWRHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVA---APVVRRVKV 195 Query: 675 SASGTSPGLSAGATVGIMIG 694 + + P +S G+ +G Sbjct: 196 TVNYP-PYISEAKGTGVPVG 214 Score = 106 bits (263), Expect = 4e-23, Method: Composition-based stats. Identities = 53/293 (18%), Positives = 100/293 (34%), Gaps = 44/293 (15%) Query: 423 SYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNI-------------------QQHTQELF 463 R G + +L C N + +WL I Q + Sbjct: 21 DNVTVRQGESATLRCTID-NRVTRVAWLNRSTILYAGNDKWCLDPRVVLLSNTQTQYSIE 79 Query: 464 ISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTC 523 I N+ + G YTC S + + + ++ + ++ + + + ++ TC Sbjct: 80 IQNVDVYDEGPYTC----SVQTDNHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTC 135 Query: 524 EPEAQNTTYLWWVNGQSLPVSPR-LQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRS 582 + + W + +SP+ + + + L + +TR + Y C N V+A Sbjct: 136 IATGRPEPTVTWRH-----ISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVV 190 Query: 583 DPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQ---- 638 V + V Y P I + G L C +++ PS ++ W + + Sbjct: 191 RRVKVTVNYPP--YISEAKGTGVPVGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKGVK 248 Query: 639 --------VLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGL 683 L ++ ++ G Y C SN N SI+ + S S GL Sbjct: 249 VENRPFLSKLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFGPGAVSEVSNGL 301 Score = 35.7 bits (80), Expect = 0.064, Method: Composition-based stats. Identities = 20/105 (19%), Positives = 34/105 (32%), Gaps = 19/105 (18%) Query: 22 ASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIG 81 +T PP ++ P V + + +P F WYK ++ R I G Sbjct: 192 RVKVTVNYPPYISEAKGTGVP--VGQKGTLQCEASAVPSAEF--QWYKDDK----RLIEG 243 Query: 82 YVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIK 126 + P + L+ N+ ++D G YT Sbjct: 244 KKGVKVENRP-----------FLSKLIFFNVSEHDYGNYTCVASN 277 >6DLD-B nrPDB Length = 304 Score = 182 bits (461), Expect = 5e-46, Method: Composition-based stats. Identities = 66/274 (24%), Positives = 104/274 (37%), Gaps = 41/274 (14%) Query: 246 NTSYRSGENLNLSCH-----AASNPPAQYS--------WFVN-----GTFQQSTQELFIP 287 N R G+ L C+ + + S W V+ T + L I Sbjct: 21 NMMVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQ 80 Query: 288 NITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEP 347 N+ V + G YTC T RT +TV PPK + SN+ V + V LTC Sbjct: 81 NVDVTDDGPYTCSVQTQHTP--RTMQVHLTVQV-PPKIYDISNDMT-VNEGTNVTLTCLA 136 Query: 348 EIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPV 407 + + W + +SP + + + L + +TR+ G YEC +N +S V Sbjct: 137 TGKPEPSISWRH-----ISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKV 191 Query: 408 ILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGN----------IQQ 457 + V + P I PG + + C A PP + W IQ Sbjct: 192 KVVVNFAPTIQEIKSGTV--TPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQN 249 Query: 458 HTQE--LFISNITEKNSGLYTCQANNSASGHSRT 489 + L ++N+T+++ G YTC A N + + Sbjct: 250 FSTRSILTVTNVTQEHFGNYTCVAANKLGTTNAS 283 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 56/240 (23%), Positives = 94/240 (39%), Gaps = 24/240 (10%) Query: 85 GTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPEL 144 G + + P S + + SL IQN+ D G YT V + T Q + ++ Sbjct: 55 GGDKWSVDPRVSISTLNKRDYSLQIQNVDVTDDGPYTCSV---QTQHTPRTMQVHLTVQV 111 Query: 145 PKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFN 204 P +N V + V TC + + W + +SP + + L ++ Sbjct: 112 PPKIYDISNDMTVNEGTNVTLTCLATGKPEPSISWRH-----ISPSAKPFENGQYLDIYG 166 Query: 205 VTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPL-NTSYRSGENLNLSCHAAS 263 +TR+ Y+C +N VS V + V + APTI + + + G + + C A Sbjct: 167 ITRDQAGEYECSAENDVSFPDVRKVKVVVNF---APTIQEIKSGTVTPGRSGLIRCEGAG 223 Query: 264 NPPAQYSWFV---------NGTFQQ---STQELFIPNITVNNSGSYTCQAHNSDTGLNRT 311 PP + W+ G Q + L + N+T + G+YTC A N N + Sbjct: 224 VPPPAFEWYKGEKKLFNGQQGIIIQNFSTRSILTVTNVTQEHFGNYTCVAANKLGTTNAS 283 Score = 152 bits (382), Expect = 6e-37, Method: Composition-based stats. Identities = 51/195 (26%), Positives = 74/195 (37%), Gaps = 15/195 (7%) Query: 509 NSKPVEDKDAVAFTCEPEAQNTTYLW-------WVNGQSLPVSPRLQLSNGNR---TLTL 558 ++ V D C E + W + G V PR+ +S N+ +L + Sbjct: 20 DNMMVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQI 79 Query: 559 FNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSA 618 NV D Y C +Q + R+ V L V P IS D + G N+ L+C + Sbjct: 80 QNVDVTDDGPYTCSVQTQHTP-RTMQVHLTVQVPPKIYDISN-DMTVNEGTNVTLTCLAT 137 Query: 619 SNPSPQYSWRI---NGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVS 675 P P SWR + P ++ Q L I IT + G Y C N + + VK + Sbjct: 138 GKPEPSISWRHISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNF 197 Query: 676 ASGTSPGLSAGATVG 690 A S T G Sbjct: 198 APTIQEIKSGTVTPG 212 Score = 122 bits (305), Expect = 5e-28, Method: Composition-based stats. Identities = 52/281 (18%), Positives = 92/281 (32%), Gaps = 41/281 (14%) Query: 418 PTISPSYTYYRPGVNLSLSCHA-ASNPPAQYS------------WLIDGN-----IQQHT 459 P + R G L C+ + W +D + + Sbjct: 15 PWAAVDNMMVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRD 74 Query: 460 QELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAV 519 L I N+ + G YTC + + + ++ ++P +N V + V Sbjct: 75 YSLQIQNVDVTDDGPYTCSVQTQHTPRT----MQVHLTVQVPPKIYDISNDMTVNEGTNV 130 Query: 520 AFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSA 579 TC + + W + + S + NG L ++ +TR+ A Y C +N VS Sbjct: 131 TLTCLATGKPEPSISWRH---ISPSAK-PFENGQY-LDIYGITRDQAGEYECSAENDVSF 185 Query: 580 NRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQ- 638 V + V + P I + G + + C A P P + W + Q Sbjct: 186 PDVRKVKVVVNFAPTIQEIK--SGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQ 243 Query: 639 -----------VLFIAKITPNNNGTYACFVSNLATGRNNSI 668 +L + +T + G Y C +N N S+ Sbjct: 244 GIIIQNFSTRSILTVTNVTQEHFGNYTCVAANKLGTTNASL 284 Score = 113 bits (283), Expect = 2e-25, Method: Composition-based stats. Identities = 64/265 (24%), Positives = 96/265 (36%), Gaps = 23/265 (8%) Query: 331 NSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSL-------PVSPRLQLSN---DNRTLTL 380 ++ V D L C E + W + + V PR+ +S + +L + Sbjct: 20 DNMMVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQI 79 Query: 381 LSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAA 440 +V D GPY C +Q + + + V L V P IS T G N++L+C A Sbjct: 80 QNVDVTDDGPYTCSVQTQHT-PRTMQVHLTVQVPPKIYDISNDMT-VNEGTNVTLTCLAT 137 Query: 441 SNPPAQYSWLI---DGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVS 497 P SW ++ Q L I IT +G Y C A N S VK + Sbjct: 138 GKPEPSISWRHISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNF 197 Query: 498 AELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTT-YLWWVNGQSLPVSPRLQLSNGNRT- 555 A P+I S V + CE + W+ + L + + T Sbjct: 198 A----PTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQNFSTR 253 Query: 556 --LTLFNVTRNDARAYVCGIQNSVS 578 LT+ NVT+ Y C N + Sbjct: 254 SILTVTNVTQEHFGNYTCVAANKLG 278 >1QZ1-A nrPDB Length = 291 Score = 182 bits (461), Expect = 5e-46, Method: Composition-based stats. Identities = 65/298 (21%), Positives = 106/298 (35%), Gaps = 43/298 (14%) Query: 43 FNVAEGKEVLLLVHNLPQHLFGYSWY--KGERVDGNRQIIGYVIGTQQATPGPAYSGREI 100 +V E K L V + SW+ GE++ N+Q I V + Sbjct: 14 ISVGESKFFLCQVAGDAKDKDI-SWFSPNGEKLSPNQQRISVVWNDDDS----------- 61 Query: 101 IYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDK 160 ++L I N +D G Y V D EAT +++ +L + N P E K Sbjct: 62 ----STLTIYNANIDDAGIYKCVVTAEDGTQSEATVNVKIFQKL----MFKNAPTPQEFK 113 Query: 161 ---DAVAFTCEPETQDATYLWWVNNQSLPVSPR-LQLSNGNRTLTLFNVTRNDTASYKCE 216 DAV + T +W + + + + N L + + + D +Y+CE Sbjct: 114 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 173 Query: 217 TQ---NPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFV 273 + + VI+NV A S +N + G+++ L C A P SW Sbjct: 174 GRILARGEINFKDIQVIVNVPPTVQA-RQSIVNATANLGQSVTLVCDADGFPEPTMSWTK 232 Query: 274 NGT-------------FQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITV 318 +G F + EL I N+ N+ Y C A N + + + Sbjct: 233 DGEPIENEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQDASIHLKVFA 290 Score = 178 bits (450), Expect = 9e-45, Method: Composition-based stats. Identities = 53/285 (18%), Positives = 106/285 (37%), Gaps = 30/285 (10%) Query: 330 NNSNPVEDEDAVALTCEPEI-QNTTYLWWVNNQSLPVSPRLQL------SNDNRTLTLLS 382 + + ++ C+ + W + +SP Q +D+ TLT+ + Sbjct: 9 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLTIYN 68 Query: 383 VTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASN 442 +D G Y+C + + V + + + +P+ ++ G + + C S+ Sbjct: 69 ANIDDAGIYKCVVTAEDGTQSEATVNVKI-FQKLMFKNAPTPQEFKEGEDAVIVCDVVSS 127 Query: 443 PPAQYSWLIDGN---IQQHTQELFISN-------ITEKNSGLYTCQANNSASGHSRTTVK 492 P W G +++ + + +SN I + + G Y C+ A G K Sbjct: 128 LPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE--INFK 185 Query: 493 TITVSAELPKPSISSNNSK---PVEDKDAVAFTCEPEAQN-TTYLWWVNGQSLPV----S 544 I V +P P++ + S +V C+ + T W +G+ + Sbjct: 186 DIQVIVNVP-PTVQARQSIVNATANLGQSVTLVCDADGFPEPTMSWTKDGEPIENEEEDD 244 Query: 545 PRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDV 589 + S+ + LT+ NV +ND YVC +N + + L V Sbjct: 245 EKHIFSDDSSELTIRNVDKNDEAEYVCIAENKAG-EQDASIHLKV 288 Score = 128 bits (320), Expect = 1e-29, Method: Composition-based stats. Identities = 51/279 (18%), Positives = 88/279 (31%), Gaps = 27/279 (9%) Query: 148 SISSNNSKPVEDKDAVAFTCEPETQDA-TYLWWVN---NQSLPVSPRLQLSNGNR---TL 200 + S V ++ F C+ + W + + P R+ + + TL Sbjct: 7 IVPSQGEISV--GESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTL 64 Query: 201 TLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPD-APTISPLNTSYRSGENLNLSC 259 T++N +D YKC +NV +P ++ GE+ + C Sbjct: 65 TIYNANIDDAGIYKCVVT--AEDGTQSEATVNVKIFQKLMFKNAPTPQEFKEGEDAVIVC 122 Query: 260 HAASNPPAQYSWFVNGT----------FQQSTQELFIPNITVNNSGSYTCQAHNSDTGLN 309 S+ P W G S L I I + G+Y C+ G Sbjct: 123 DVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEI 182 Query: 310 RTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRL 369 + V P S + +V L C+ + + W + + Sbjct: 183 NFKDIQVIVNVPPTVQARQSIVNATANLGQSVTLVCDADGFPEPTMSWTKDGEPIENEEE 242 Query: 370 Q-----LSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDH 403 S+D+ LT+ +V +ND Y C +NK Sbjct: 243 DDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQD 281 Score = 123 bits (308), Expect = 3e-28, Method: Composition-based stats. Identities = 46/284 (16%), Positives = 87/284 (30%), Gaps = 41/284 (14%) Query: 420 ISPSYTYYRPGVNLSLSCHAASNPP-AQYSWL-IDGNI-------------QQHTQELFI 464 I PS G + C A + SW +G + L I Sbjct: 7 IVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLTI 66 Query: 465 SNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCE 524 N ++G+Y C + + T+ V ++ + ++ + C+ Sbjct: 67 YNANIDDAGIYKCVVT---AEDGTQSEATVNVKIFQKLMFKNAPTPQEFKEGEDAVIVCD 123 Query: 525 P-EAQNTTYLW-WVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVC----GIQNSVS 578 + T +W + + N L + + + D Y C + ++ Sbjct: 124 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 183 Query: 579 ANRSDPVTLDVLYGPDTPI-ISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIP---- 633 + + V P S +++ G ++ L C + P P SW +G P Sbjct: 184 FK---DIQVIVNVPPTVQARQSIVNATANLGQSVTLVCDADGFPEPTMSWTKDGEPIENE 240 Query: 634 ---------QQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSI 668 + L I + N+ Y C N A ++ SI Sbjct: 241 EEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQDASI 284 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 18/88 (20%), Positives = 28/88 (31%), Gaps = 15/88 (17%) Query: 597 IISPPDSSYLSGANLNLSCHSASNPSPQ-YSWRI-NG---IPQQ----------HTQVLF 641 I P G + C A + + SW NG P Q + L Sbjct: 6 DIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLT 65 Query: 642 IAKITPNNNGTYACFVSNLATGRNNSIV 669 I ++ G Y C V+ ++ + V Sbjct: 66 IYNANIDDAGIYKCVVTAEDGTQSEATV 93 >2WIM-A nrPDB Length = 291 Score = 177 bits (448), Expect = 2e-44, Method: Composition-based stats. Identities = 72/316 (22%), Positives = 116/316 (36%), Gaps = 50/316 (15%) Query: 23 SLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWY--KGERVDGNRQII 80 S+ + +K+ +V E K P+ + WY +GE++ ++++ Sbjct: 1 SMALLQVTISLSKVE-----LSVGESKFFTCTAIGEPESI---DWYNPQGEKIISTQRVV 52 Query: 81 GYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRV 140 G + L I N D G Y + +EAT + Sbjct: 53 VQKEGV-----------------RSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEI 95 Query: 141 YPEL-PKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWW--VNNQSLPVSPRLQLSNGN 197 Y +L + +S K ED + V C + A + W N + +S N Sbjct: 96 YQKLTFREVVSPQEFKQGEDAEVV---CRVSSSPAPAVSWLYHNEEVTTISDNRFAMLAN 152 Query: 198 RTLTLFNVTRNDTASYKCETQNPVSAR-----RSDSVILNVLYGPDAPTISPLNTSYRSG 252 L + N+ ++D Y+CE + V AR R VI+NV P S N + G Sbjct: 153 NNLQILNINKSDEGIYRCEGR--VEARGEIDFRDIIVIVNVPPAISMPQKS-FNATAERG 209 Query: 253 ENLNLSCHAASNPPAQYSWFVNGT---------FQQSTQELFIPNITVNNSGSYTCQAHN 303 E + SC A+ +P SWF NG + S EL + NI ++ G Y C+A N Sbjct: 210 EEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATN 269 Query: 304 SDTGLNRTTVTTITVY 319 + + V Sbjct: 270 KAGEDEKQAFLQVFVQ 285 Score = 175 bits (443), Expect = 6e-44, Method: Composition-based stats. Identities = 63/280 (22%), Positives = 105/280 (37%), Gaps = 27/280 (9%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFV-NGTFQQST-----------QELFIPN 288 TIS GE+ +C A P W+ G ST L I N Sbjct: 8 TISLSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYN 66 Query: 289 ITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPE 348 + ++G Y CQA ++ TV + ++ ED + V Sbjct: 67 ANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSP 126 Query: 349 IQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECG--IQNKLSVDHSD- 405 ++L+ N + +S N L +L++ ++D G Y C ++ + +D D Sbjct: 127 APAVSWLYH-NEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDI 185 Query: 406 PVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQE---- 461 VI+NV P S + T R G ++ SC A+ +P SW +G + + ++ Sbjct: 186 IVIVNVPPAISMPQKSFNATAER-GEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILK 244 Query: 462 -----LFISNITEKNSGLYTCQANNSASGHSRTTVKTITV 496 L + NI + G Y C+A N A + + V Sbjct: 245 GSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV 284 Score = 163 bits (411), Expect = 3e-40, Method: Composition-based stats. Identities = 50/265 (18%), Positives = 91/265 (34%), Gaps = 21/265 (7%) Query: 338 EDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRT---LTLLSVTRNDVGPYECG 394 ++ TC + + W+ +S + + LT+ + D G Y C Sbjct: 19 GESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQ 78 Query: 395 IQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGN 454 + V+L + Y S ++ G + + C +S+P SWL Sbjct: 79 ATDAKGQTQEATVVLEI-YQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNE 137 Query: 455 I---QQHTQELFI-------SNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPS 504 + + NI + + G+Y C+ A G + I V +P P+ Sbjct: 138 EVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGE--IDFRDIIVIVNVP-PA 194 Query: 505 ISSNN---SKPVEDKDAVAFTCEPEAQN-TTYLWWVNGQSLPVSPRLQLSNGNRTLTLFN 560 IS + E + + F+C W+ NG+ + + + L N LT+ N Sbjct: 195 ISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRN 254 Query: 561 VTRNDARAYVCGIQNSVSANRSDPV 585 + +D YVC N + Sbjct: 255 IINSDGGPYVCRATNKAGEDEKQAF 279 Score = 112 bits (280), Expect = 4e-25, Method: Composition-based stats. Identities = 56/283 (19%), Positives = 94/283 (33%), Gaps = 33/283 (11%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQYSWL-IDGNIQQH-----------TQELFISN 466 TIS S G + +C A P W G L I N Sbjct: 8 TISLSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYN 66 Query: 467 ITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPE 526 +++G+Y CQA + A G ++ + + +L + S + + C Sbjct: 67 ANIEDAGIYRCQATD-AKGQTQEATVVLEIYQKLTFREVVSPQEF--KQGEDAEVVCRVS 123 Query: 527 AQN-TTYLW-WVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDP 584 + W + N + +S N L + N+ ++D Y C + V A Sbjct: 124 SSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRC--EGRVEARGEID 181 Query: 585 VTLDVLYGPDTPIISPPDSSYLS----GANLNLSCHSASNPSPQYSWRINGIPQQH---- 636 ++ P IS P S+ + G + SC ++ +P P SW NG + Sbjct: 182 FRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKY 241 Query: 637 -----TQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITV 674 L + I ++ G Y C +N A + V Sbjct: 242 ILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFV 284 >4MYW-B nrPDB Length = 331 Score = 170 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 58/247 (23%), Positives = 94/247 (38%), Gaps = 27/247 (10%) Query: 272 FVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSN- 330 F +GT + S EL + G Y C+ TG NR + +TV A+P + Sbjct: 89 FTDGTIRLSRLEL-------EDEGVYICEFATFPTG-NRESQLNLTVMAKPTNWIEGTQA 140 Query: 331 --NSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDV 388 + +D+ + TC + + + ++ N N T+T+ ++R + Sbjct: 141 VLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTV--ISRYRL 198 Query: 389 GPYECGIQNKLSV-------DHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAAS 441 P Q L+ + + LNV Y P+ +Y +++ L+C A + Sbjct: 199 VPSREAHQQSLACIVNYHMDRFKESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADA 258 Query: 442 NPPAQ-YSW------LIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTI 494 NPPA Y W L G Q+ F I +G Y C+A N S I Sbjct: 259 NPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNI 318 Query: 495 TVSAELP 501 T +A L Sbjct: 319 TEAAALE 325 Score = 105 bits (261), Expect = 8e-23, Method: Composition-based stats. Identities = 55/301 (18%), Positives = 106/301 (35%), Gaps = 29/301 (9%) Query: 403 HSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQH---- 458 V+L+ + P++ + ++ N S A NP S L + Sbjct: 28 IGTDVVLHCSFANPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRP 87 Query: 459 ---TQELFISNITEKNSGLYTCQ-ANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVE 514 + +S + ++ G+Y C+ A + +TV A+ + + Sbjct: 88 SFTDGTIRLSRLELEDEGVYICEFATFPTGNRE--SQLNLTVMAKPTNWIEGTQAVLRAK 145 Query: 515 DKDA----VAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLT------LFNVTRN 564 VA + + + W + ++ N N T+T L Sbjct: 146 KGQDDKVLVATCTSANGKPPSVVSWETRLK-GEAEYQEIRNPNGTVTVISRYRLVPSREA 204 Query: 565 DARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQ 624 ++ C + N + +TL+V Y P+ I + YL ++ L+C + +NP Sbjct: 205 HQQSLACIV-NYHMDRFKESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPAT 263 Query: 625 -YSW------RINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSAS 677 Y W G+ Q+ + F I + GTY C +N R+ + +IT +A+ Sbjct: 264 EYHWTTLNGSLPKGVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEAAA 323 Query: 678 G 678 Sbjct: 324 L 324 Score = 69.2 bits (167), Expect = 6e-12, Method: Composition-based stats. Identities = 55/297 (18%), Positives = 97/297 (32%), Gaps = 29/297 (9%) Query: 45 VAEGKEVLLLVHN-LPQHLFG-YSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIY 102 + + N LP +W K +G++Q + + + Y R Sbjct: 28 IGTDVVLHCSFANPLPSVKITQVTWQKS--TNGSKQNVAIYNPSMGVSVLAPYRERVEFL 85 Query: 103 P----NASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVE 158 + ++ + + D G Y N E+ V + + + Sbjct: 86 RPSFTDGTIRLSRLELEDEGVYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAK 145 Query: 159 DKDA----VAFTCEPETQDATYLWWVN------NQSLPVSPRLQLSNGNRTLTLFNVTRN 208 VA + + + W +P ++ +R L Sbjct: 146 KGQDDKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRY-RLVPSREA 204 Query: 209 DTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTS-YRSGENLNLSCHAASNPPA 267 S C N R +S+ LNV Y P+ TI + + Y ++ L+C A +NPPA Sbjct: 205 HQQSLACIV-NYHMDRFKESLTLNVQYEPEV-TIEGFDGNWYLQRMDVKLTCKADANPPA 262 Query: 268 Q-YSWFV-NGTF----QQSTQELFIPN-ITVNNSGSYTCQAHNSDTGLNRTTVTTIT 317 Y W NG+ + + LF I + +G+Y C+A N + IT Sbjct: 263 TEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNIT 319 Score = 67.3 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 54/318 (16%), Positives = 91/318 (28%), Gaps = 56/318 (17%) Query: 319 YAEPPKPFITSNNSNPVEDEDAVALTCEPEIQ----NTTYLWWVNN-------------- 360 P + N+S V L C T + W + Sbjct: 10 MGRDPSQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNGSKQNVAIYNPS 69 Query: 361 -QSLPVSPR------LQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLY 413 ++P L+ S + T+ L + D G Y C + + + L V+ Sbjct: 70 MGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGNRESQLNLTVMA 129 Query: 414 GPDDPTISPSYTY-YRPGVN---LSLSCH-AASNPPAQYSWL--------------IDGN 454 P + + G + L +C A PP+ SW +G Sbjct: 130 KPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGT 189 Query: 455 IQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVE 514 + + E + C N + + E+ N Sbjct: 190 VTV-ISRYRLVPSREAHQQSLACIVNYHMDRFKESLTLNVQYEPEVTIEGFDGN---WYL 245 Query: 515 DKDAVAFTCEPEAQNTT--YLWWVNGQSLPVSPRLQLSNGNRTLTLF-NVTRNDARAYVC 571 + V TC+ +A Y W SLP + NRTL + + A Y+C Sbjct: 246 QRMDVKLTCKADANPPATEYHWTTLNGSLPKG----VEAQNRTLFFKGPINYSLAGTYIC 301 Query: 572 GIQNSVSANRSDPVTLDV 589 N + RS V +++ Sbjct: 302 EATNPIG-TRSGQVEVNI 318 Score = 63.4 bits (152), Expect = 3e-10, Method: Composition-based stats. Identities = 53/245 (21%), Positives = 82/245 (33%), Gaps = 29/245 (11%) Query: 191 LQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPD---APTISPLNT 247 L+ S + T+ L + D Y CE + R + L V+ P T + L Sbjct: 85 LRPSFTDGTIRLSRLELEDEGVYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRA 144 Query: 248 SYRSGENLNL-SCH-AASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSY-------- 297 + + + +C A PP+ SW + QE+ PN TV Y Sbjct: 145 KKGQDDKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREA 204 Query: 298 -----TCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNT 352 C + T+ V EP + + ++ D V LTC+ + Sbjct: 205 HQQSLACIVNY--HMDRFKESLTLNVQYEPEVTIEGFDGNWYLQRMD-VKLTCKADANPP 261 Query: 353 TYLWWVN--NQSLPVSPRLQLSNDNRTLTLLS-VTRNDVGPYECGIQNKLSVDHSDPVIL 409 + N SLP Q NRTL + + G Y C N + S V + Sbjct: 262 ATEYHWTTLNGSLPKGVEAQ----NRTLFFKGPINYSLAGTYICEATNPIGTR-SGQVEV 316 Query: 410 NVLYG 414 N+ Sbjct: 317 NITEA 321 >3K0W-A nrPDB Length = 218 Score = 167 bits (421), Expect = 2e-41, Method: Composition-based stats. Identities = 45/183 (24%), Positives = 70/183 (38%), Gaps = 26/183 (14%) Query: 508 NNSKPVEDKDAVAFTCEPEAQN-TTYLWWVNGQSLPVSPRLQLSNGNRTLTLFN-VTRND 565 SK V V C Y W+ + +P NGN + +FN V D Sbjct: 25 PESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIP--------NGNTSELIFNAVHVKD 76 Query: 566 ARAYVCGIQNSVSANRSDPVTLDVLYGPDT--------------PIISPPDSSYLSGANL 611 A YVC + N+ + S LDV P++ + P + G+ L Sbjct: 77 AGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTL 136 Query: 612 NLSCHSASNPSPQYSWRINGIPQQH--TQVLFIAKITPNNNGTYACFVSNLATGRNNSIV 669 L C + +P P Y W N +P H ++ + + + GTY C V N +++ V Sbjct: 137 VLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKV 196 Query: 670 KSI 672 + I Sbjct: 197 EII 199 Score = 135 bits (340), Expect = 5e-32, Method: Composition-based stats. Identities = 43/183 (23%), Positives = 65/183 (35%), Gaps = 26/183 (14%) Query: 153 NSKPVEDKDAVAFTCEPETQD-ATYLWWVNNQSLPVSPRLQLSNGNRTLTLFN-VTRNDT 210 SK V V C Y W+ N+ +P NGN + +FN V D Sbjct: 26 ESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIP--------NGNTSELIFNAVHVKDA 77 Query: 211 ASYKCETQNPVSARRSDSVILNVLYGPDAP--------------TISPLNTSYRSGENLN 256 Y C N + S L+V P++ + P + G L Sbjct: 78 GFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTLV 137 Query: 257 LSCHAASNPPAQYSWFVNGTF-QQSTQELF-IPNITVNNSGSYTCQAHNSDTGLNRTTVT 314 L C A +P Y WF N T++L+ +P + + + G+Y C +N + V Sbjct: 138 LQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKVE 197 Query: 315 TIT 317 I Sbjct: 198 III 200 Score = 78.8 bits (192), Expect = 8e-15, Method: Composition-based stats. Identities = 35/183 (19%), Positives = 56/183 (30%), Gaps = 24/183 (13%) Query: 329 SNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLS-VTRND 387 + S V V L C W ++ N N + + + V D Sbjct: 24 NPESKAVLAGQFVKLCCRATGHPFVQYQWFK-------MNKEIPNGNTSELIFNAVHVKD 76 Query: 388 VGPYECGIQNKLSVDHSDPVILNVLYGPDDPT--------------ISPSYTYYRPGVNL 433 G Y C + N + + S L+V P+ + P+ PG L Sbjct: 77 AGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPGSTL 136 Query: 434 SLSCHAASNPPAQYSWLIDGNIQQHTQE--LFISNITEKNSGLYTCQANNSASGHSRTTV 491 L C A +P Y W + H + + + ++ G Y C N V Sbjct: 137 VLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQDSKKV 196 Query: 492 KTI 494 + I Sbjct: 197 EII 199 Score = 70.0 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 34/193 (17%), Positives = 65/193 (33%), Gaps = 20/193 (10%) Query: 233 VLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFV--NGTFQQSTQELFIPNIT 290 ++ T++P + + +G+ + L C A +P QY WF +T EL + Sbjct: 14 LVPRGSKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVH 73 Query: 291 VNNSGSYTCQAHNSDT------------GLNRTTVTTITVYAEPPKPFITSNNSNPVEDE 338 V ++G Y C+ +N+ T + + ++ +E S + Sbjct: 74 VKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPG 133 Query: 339 DAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNK 398 + L C + W N+ +L + V G Y C + N Sbjct: 134 STLVLQCVAVGSPIPHYQWFKNELPLTHETKKLY------MVPYVDLEHQGTYWCHVYND 187 Query: 399 LSVDHSDPVILNV 411 S V + + Sbjct: 188 RDSQDSKKVEIII 200 Score = 66.5 bits (160), Expect = 4e-11, Method: Composition-based stats. Identities = 35/210 (16%), Positives = 68/210 (32%), Gaps = 27/210 (12%) Query: 411 VLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQ--HTQELFISNIT 468 ++ T++P G + L C A +P QY W +T EL + + Sbjct: 14 LVPRGSKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVH 73 Query: 469 EKNSGLYTCQANNS------------ASGHSRTTVKTITVSAELPKPSISSNNSKPVEDK 516 K++G Y C+ NN+ + +++ +E S+ + Sbjct: 74 VKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMPG 133 Query: 517 DAVAFTCEPEAQNTT-YLWWVNGQSLPVSPRLQLSNGNRTLTLFN-VTRNDARAYVCGIQ 574 + C Y W+ N L ++ + L + V Y C + Sbjct: 134 STLVLQCVAVGSPIPHYQWFKNELPL--------THETKKLYMVPYVDLEHQGTYWCHVY 185 Query: 575 NSVSANRSDPVTLDVLYGPDTPIISPPDSS 604 N + S V + + + + PD+ Sbjct: 186 NDRDSQDSKKVEIII---DELNNLGHPDNK 212 Score = 48.8 bits (114), Expect = 8e-06, Method: Composition-based stats. Identities = 36/218 (16%), Positives = 58/218 (26%), Gaps = 52/218 (23%) Query: 31 PTTAKLTI--ESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQ 88 P +K+T+ ES + ++ P Y W+K + N Sbjct: 16 PRGSKITVNPESKAVLAGQFVKLCCRATGHP--FVQYQWFKMNKEIPNG----------- 62 Query: 89 ATPGPAYSGREIIYPNASLLIQN-IIQNDTGFYTLHVIKSDLVNEEATGQFRV--YPELP 145 N S LI N + D GFY V + Q V PE Sbjct: 63 ---------------NTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESF 107 Query: 146 KPSISSNNSKPVE-----------DKDAVAFTCEPETQDAT-YLWWVNNQSLPVSPRLQL 193 + S+ + ++ + C Y W+ N L + Sbjct: 108 QRSVDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLY 167 Query: 194 SNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVIL 231 L +Y C N ++ S V + Sbjct: 168 MVPYVDL-------EHQGTYWCHVYNDRDSQDSKKVEI 198 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 18/64 (28%), Positives = 29/64 (45%), Gaps = 2/64 (3%) Query: 598 ISPPDSSYLSGANLNLSCHSASNPSPQYSWRI--NGIPQQHTQVLFIAKITPNNNGTYAC 655 ++P + L+G + L C + +P QY W IP +T L + + G Y C Sbjct: 23 VNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAVHVKDAGFYVC 82 Query: 656 FVSN 659 V+N Sbjct: 83 RVNN 86 >5VI4-B nrPDB Length = 309 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 61/291 (20%), Positives = 105/291 (36%), Gaps = 48/291 (16%) Query: 151 SNNSKPVEDKDAVAFTCEPETQDATY--LWWVN--NQSLPVSPRLQLSNGNRTLTLFNVT 206 + S + +A+ C P+ +TY W+ + N+S+P R ++ L Sbjct: 3 GSKSSWGLENEALIVRC-PQRGRSTYPVEWYYSDTNESIPTQKRNRIFVSRDRLKFLPAR 61 Query: 207 RNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS-----PLNTSYRSGENLNLSCHA 261 D+ Y C ++P + + LNV P+ + +T S +N ++C Sbjct: 62 VEDSGIYACVIRSP---NLNKTGYLNVTIHKKPPSCNIPDYLMYSTVRGSDKNFKITCPT 118 Query: 262 AS--NPPAQYSWFVNGT------FQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTV 313 N A WF N F+ LFI N+T ++ G YTCQ +++ G N Sbjct: 119 IDLYNWTAPVQWFKNCKALQEPRFRAHRSYLFIDNVTHDDEGDYTCQFTHAENGTNYIVT 178 Query: 314 TTITVYAEPPK----PFITSN---NSNPVEDEDAVALTCEPEIQNTTY-----LWWVN-- 359 T + E P IT+ ++ VE ++ C ++ LW +N Sbjct: 179 ATRSFTVEEKGFSMFPVITNPPYNHTMEVEIGKPASIACSACFGKGSHFLADVLWQINKT 238 Query: 360 ------------NQSLPVSPRLQLSNDNRTLTLLSVTRNDVG-PYECGIQN 397 + S + L + VT D+ Y+C N Sbjct: 239 VVGNFGEARIQEEEGRNESSSNDMDCLTSVLRITGVTEKDLSLEYDCLALN 289 Score = 66.5 bits (160), Expect = 4e-11, Method: Composition-based stats. Identities = 57/285 (20%), Positives = 96/285 (33%), Gaps = 46/285 (16%) Query: 337 DEDAVALTCEPEIQNTTYLWWV---NNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYEC 393 + +A+ + C ++T + W N+S+P R ++ L L D G Y C Sbjct: 11 ENEALIVRCPQRGRSTYPVEWYYSDTNESIPTQKRNRIFVSRDRLKFLPARVEDSGIYAC 70 Query: 394 GIQNKLSVDHSDPVILNVLYGPDDPTIS-PSYTYYRP----GVNLSLSCHAAS--NPPAQ 446 I+ S + + LNV P+ + P Y Y N ++C N A Sbjct: 71 VIR---SPNLNKTGYLNVTIHKKPPSCNIPDYLMYSTVRGSDKNFKITCPTIDLYNWTAP 127 Query: 447 YSWLIDGNIQQ------HTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAEL 500 W + Q H LFI N+T + G YTCQ ++ +G + T + + E Sbjct: 128 VQWFKNCKALQEPRFRAHRSYLFIDNVTHDDEGDYTCQFTHAENGTNYIVTATRSFTVEE 187 Query: 501 P----KPSISSNN---SKPVEDKDAVAFTCEP----EAQNTTYLWWVNGQSLP------- 542 P I++ + VE + C + + W +++ Sbjct: 188 KGFSMFPVITNPPYNHTMEVEIGKPASIACSACFGKGSHFLADVLWQINKTVVGNFGEAR 247 Query: 543 --------VSPRLQLSNGNRTLTLFNVTRND-ARAYVCGIQNSVS 578 S + L + VT D + Y C N Sbjct: 248 IQEEEGRNESSSNDMDCLTSVLRITGVTEKDLSLEYDCLALNLHG 292 Score = 58.4 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 34/167 (20%), Positives = 59/167 (35%), Gaps = 19/167 (11%) Query: 515 DKDAVAFTCEPEAQNT-TYLWWVNG--QSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVC 571 + +A+ C ++T W+ + +S+P R ++ L D+ Y C Sbjct: 11 ENEALIVRCPQRGRSTYPVEWYYSDTNESIPTQKRNRIFVSRDRLKFLPARVEDSGIYAC 70 Query: 572 GIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLS-----GANLNLSCHSAS--NPSPQ 624 I++ L+V P + PD S N ++C + N + Sbjct: 71 VIRSPNLNKTGY---LNVTIHKKPPSCNIPDYLMYSTVRGSDKNFKITCPTIDLYNWTAP 127 Query: 625 YSWRINGIPQQ------HTQVLFIAKITPNNNGTYACFVSNLATGRN 665 W N Q H LFI +T ++ G Y C ++ G N Sbjct: 128 VQWFKNCKALQEPRFRAHRSYLFIDNVTHDDEGDYTCQFTHAENGTN 174 Score = 56.1 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 48/215 (22%), Positives = 67/215 (31%), Gaps = 26/215 (12%) Query: 93 PAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSN 152 P I L D+G Y + N TG V PS + Sbjct: 41 PTQKRNRIFVSRDRLKFLPARVEDSGIYACVIRS---PNLNKTGYLNVTIHKKPPSCNIP 97 Query: 153 ---NSKPVEDKD-AVAFTCEPETQ---DATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNV 205 V D TC A W+ N ++L PR L + NV Sbjct: 98 DYLMYSTVRGSDKNFKITCPTIDLYNWTAPVQWFKNCKAL-QEPR--FRAHRSYLFIDNV 154 Query: 206 TRNDTASYKCE------TQNP-VSARRSDSVILNVLYGPDAPTISPLNTS--YRSGENLN 256 T +D Y C+ N V+A RS +V T P N + G+ + Sbjct: 155 THDDEGDYTCQFTHAENGTNYIVTATRSFTVEEKGFSMFPVITNPPYNHTMEVEIGKPAS 214 Query: 257 LSCHA----ASNPPAQYSWFVNGTFQQSTQELFIP 287 ++C A S+ A W +N T + E I Sbjct: 215 IACSACFGKGSHFLADVLWQINKTVVGNFGEARIQ 249 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 30/144 (20%), Positives = 48/144 (33%), Gaps = 28/144 (19%) Query: 104 NASLLIQNIIQNDTGFYTL---HVIKSDLVNEEATGQFRVYPELP--KPSISS---NNSK 155 + L I N+ +D G YT H AT F V + P I++ N++ Sbjct: 146 RSYLFIDNVTHDDEGDYTCQFTHAENGTNYIVTATRSFTVEEKGFSMFPVITNPPYNHTM 205 Query: 156 PVEDKDAVAFTCEPETQDATY----LWWVNNQSL---PVSPRLQLSNGNR---------- 198 VE + C ++ + W N+++ R+Q G Sbjct: 206 EVEIGKPASIACSACFGKGSHFLADVLWQINKTVVGNFGEARIQEEEGRNESSSNDMDCL 265 Query: 199 --TLTLFNVTRND-TASYKCETQN 219 L + VT D + Y C N Sbjct: 266 TSVLRITGVTEKDLSLEYDCLALN 289 >3S97-C nrPDB Length = 201 Score = 148 bits (374), Expect = 6e-36, Method: Composition-based stats. Identities = 43/194 (22%), Positives = 74/194 (38%), Gaps = 26/194 (13%) Query: 133 EATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQ---DATYLWWVNNQSLPV-- 187 +G +P +P + V++ + C+P D +Y W +N + + Sbjct: 2 PGSGYLDPFPPEERPEVR------VKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITM 55 Query: 188 SPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPD---APTISP 244 R +S N L + NV +D +Y C +P + S + ++ P+ P + Sbjct: 56 DKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPAD 115 Query: 245 LNTSYRS-----GENLNLSCHAASNPPAQYSWFVNGTFQQSTQE-------LFIPNITVN 292 + ++ G+N+ L C A NP W ST E L I NI + Sbjct: 116 IVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLE 175 Query: 293 NSGSYTCQAHNSDT 306 + G Y C+A N Sbjct: 176 DEGIYECEAENIRG 189 Score = 95.4 bits (235), Expect = 7e-20, Method: Composition-based stats. Identities = 36/185 (19%), Positives = 61/185 (32%), Gaps = 20/185 (10%) Query: 508 NNSKPVEDKDAVAFTCEPEAQNT---TYLWWVNGQS--LPVSPRLQLSNGNRTLTLFNVT 562 V++ + C+P +Y W +N + + R +S N L + NV Sbjct: 15 RPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVE 74 Query: 563 RNDARAYVCGIQNS-VSANRSDPVTLDVLYG-------PDTPIISPPDSSYLSGANLNLS 614 +D Y C + + ++ + + P ++ D L G N+ L Sbjct: 75 ASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLE 134 Query: 615 CHSASNPSPQYSWRINGIP-------QQHTQVLFIAKITPNNNGTYACFVSNLATGRNNS 667 C + NP P WR P VL I I + G Y C N+ + Sbjct: 135 CFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQ 194 Query: 668 IVKSI 672 + Sbjct: 195 ARIYV 199 Score = 93.1 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 41/197 (20%), Positives = 68/197 (34%), Gaps = 22/197 (11%) Query: 319 YAEPPKPFITSNNSNPVEDEDAVALTCEPEIQ---NTTYLWWVNNQSLPV--SPRLQLSN 373 Y +P P V++ + L C+P + +Y W +N + + R +S Sbjct: 6 YLDPFPPEERPE--VRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQ 63 Query: 374 DNRTLTLLSVTRNDVGPYECGIQN-KLSVDHSDPVILNVLYG-------PDDPTISPSYT 425 N L + +V +D G Y C + + ++ I + P D + Sbjct: 64 TNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDV 123 Query: 426 YYRPGVNLSLSCHAASNPPAQYSWLI-------DGNIQQHTQELFISNITEKNSGLYTCQ 478 Y G N++L C A NP W I L I NI ++ G+Y C+ Sbjct: 124 YALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECE 183 Query: 479 ANNSASGHSRTTVKTIT 495 A N + Sbjct: 184 AENIRGKDKHQARIYVQ 200 Score = 78.8 bits (192), Expect = 7e-15, Method: Composition-based stats. Identities = 33/188 (17%), Positives = 57/188 (30%), Gaps = 21/188 (11%) Query: 415 PDDPTISPSYTYYRPGVNLSLSCHAASNPPAQ--YSWL-----------IDGNIQQHTQE 461 P P P + G + L C + P Y WL + Q Sbjct: 9 PFPPEERP-EVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGN 67 Query: 462 LFISNITEKNSGLYTCQANNSASGHSR-TTVKTITVSAE---LPKPS--ISSNNSKPVED 515 L+I+N+ + G Y+C ++ + S + + E P P+ + Sbjct: 68 LYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALM 127 Query: 516 KDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQN 575 V C + W S ++S L +FN+ D Y C +N Sbjct: 128 GQNVTLECFALGNPVPDIRWRKVLEPMPS-TAEISTSGAVLKIFNIQLEDEGIYECEAEN 186 Query: 576 SVSANRSD 583 ++ Sbjct: 187 IRGKDKHQ 194 Score = 72.3 bits (175), Expect = 6e-13, Method: Composition-based stats. Identities = 24/129 (18%), Positives = 40/129 (31%), Gaps = 8/129 (6%) Query: 98 REIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYP-------ELPKPSIS 150 R + N +L I N+ +D G Y+ V + + + P P + Sbjct: 59 RFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVV 118 Query: 151 SNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDT 210 V C + W S ++S L +FN+ D Sbjct: 119 QFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPS-TAEISTSGAVLKIFNIQLEDE 177 Query: 211 ASYKCETQN 219 Y+CE +N Sbjct: 178 GIYECEAEN 186 Score = 33.0 bits (73), Expect = 0.43, Method: Composition-based stats. Identities = 15/51 (29%), Positives = 19/51 (37%), Gaps = 3/51 (5%) Query: 93 PAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPE 143 P S EI A L I NI D G Y ++ Q R+Y + Sbjct: 153 PMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKH---QARIYVQ 200 >5OYJ-C nrPDB Length = 234 Score = 135 bits (338), Expect = 8e-32, Method: Composition-based stats. Identities = 49/229 (21%), Positives = 83/229 (36%), Gaps = 34/229 (14%) Query: 140 VYPELPKPSISSNNSKPVED--KDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGN 197 E P + S VE + V + + W N +P+ + G+ Sbjct: 2 PLAEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKN-GIPLESNHTIKAGH 60 Query: 198 RTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGP----DAPTISPLNTSYRSGE 253 LT+ V+ DT +Y NP+S + V+ V+Y P + ISP++ SY+ G Sbjct: 61 -VLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVD-SYQYGT 118 Query: 254 NLNLSCHAASNPPAQY-SWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNS-------- 304 L+C + PP + W+ +Q + P+ V+ + Y C+ S Sbjct: 119 TQTLTCTVYAIPPPHHIHWY----WQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGN 174 Query: 305 -----------DTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVA 342 G N+ TV+T+ + A N V + V Sbjct: 175 KIEVNKNQFALIEGKNK-TVSTLVIQAANVSALYKCEAVNKVGRGERVI 222 Score = 108 bits (268), Expect = 1e-23, Method: Composition-based stats. Identities = 35/137 (25%), Positives = 53/137 (38%), Gaps = 15/137 (10%) Query: 498 AELPKPSISSNNSKPVEDKDAVAFTCEPEAQ-----NTTYLWWVNGQSLPVSPRLQLSNG 552 AE P + S VE V A+ W+ NG +P+ + G Sbjct: 4 AEKPFVAFGSGMESLVEA--TVGERVRIPAKYLGYPPPEIKWYKNG--IPLESNHTIKAG 59 Query: 553 NRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGP----DTPIISPPDSSYLSG 608 + LT+ V+ D Y + N +S + V V+Y P + +ISP D SY G Sbjct: 60 H-VLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVD-SYQYG 117 Query: 609 ANLNLSCHSASNPSPQY 625 L+C + P P + Sbjct: 118 TTQTLTCTVYAIPPPHH 134 Score = 60.0 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 25/143 (17%), Positives = 47/143 (32%), Gaps = 12/143 (8%) Query: 422 PSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQE------LFISNITEKNSGLY 475 S G + + PP + W +G + L I ++E+++G Y Sbjct: 16 ESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNY 75 Query: 476 TCQANNSASGHSRTTV--KTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYL 533 T N S ++ V + V ++ + S+ S + TC A + Sbjct: 76 TVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDS-YQYGTTQTLTCTVYAIPPPHH 134 Query: 534 ---WWVNGQSLPVSPRLQLSNGN 553 +W + P +S N Sbjct: 135 IHWYWQLEEECANEPSQAVSVTN 157 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 24/136 (17%), Positives = 46/136 (33%), Gaps = 7/136 (5%) Query: 320 AEPPKPFITSNNSNP-VEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTL 378 +P F + S + V + + + W N S L Sbjct: 5 EKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHT--IKAGHVL 62 Query: 379 TLLSVTRNDVGPYECGIQNKLSVD---HSDPVILNVLYGPDDPTISPSYTYYRPGVNLSL 435 T++ V+ D G Y + N +S + H +++ V + ++ Y+ G +L Sbjct: 63 TIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTL 122 Query: 436 SCHAASNPPA-QYSWL 450 +C + PP W Sbjct: 123 TCTVYAIPPPHHIHWY 138 Score = 41.8 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 17/74 (22%), Positives = 29/74 (39%), Gaps = 6/74 (8%) Query: 607 SGANLNLSCHSASNPSPQYSWRINGIPQQHTQV------LFIAKITPNNNGTYACFVSNL 660 G + + P P+ W NGIP + L I +++ + G Y ++N Sbjct: 23 VGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNP 82 Query: 661 ATGRNNSIVKSITV 674 + S V S+ V Sbjct: 83 ISKEKQSHVVSLVV 96 >5T89-X nrPDB Length = 646 Score = 130 bits (325), Expect = 3e-30, Method: Composition-based stats. Identities = 86/592 (14%), Positives = 168/592 (28%), Gaps = 111/592 (18%) Query: 97 GREIIYPNASLLIQNIIQNDTGFYTL---HVIKSDLVNEEATGQFRVYPELPKPSISSNN 153 GR ++L + N TGFY+ V S E+ + + +P + + Sbjct: 56 GRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFI-SDTGRPFVEMYS 114 Query: 154 SKP----VEDKDAVAFTCEPETQDATYLWWVNN--QSLPVSPRLQLSNGNRTLTLFNVTR 207 P + + + C + + +L + + + + + N T Sbjct: 115 EIPEIIHMTEGRELVIPCRVTS-PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATY 173 Query: 208 NDTASYKCETQ-------NPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCH 260 + CE R + I++V P G L L+C Sbjct: 174 KEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRP------VKLLRGHTLVLNCT 227 Query: 261 AAS--NPPAQYSWFVNGTFQQST-----------------QELFIPNITVNNSGSYTCQA 301 A + N Q +W + L I + + G YTC+ Sbjct: 228 ATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRV 287 Query: 302 HNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQ 361 + + + T I A V + + L+ + + + + W+ + Sbjct: 288 RSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDG 347 Query: 362 SLPVSPRLQLSNDNRTLTLLSVTRNDVGPYE---CGIQNKLSVDHSDPVILNVLYGPDDP 418 + +L + VT D G Y Q+ + + + +I+NV + Sbjct: 348 LPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEK 407 Query: 419 TIS--PSYTYYRPGVNLSLSCHAASNPPAQYSWL-------------------------- 450 +S P Y G L+C A P W Sbjct: 408 AVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILD 467 Query: 451 ------------------IDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVK 492 I+G + L +++ G+Y C A+N R Sbjct: 468 ADSNMGNRIESITQRMAIIEGK-NKMASTLVVADSRIS--GIYICIASNKVGTVGR---- 520 Query: 493 TITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQ-NTTYLW----WVNGQSL---PVS 544 I+ N K + + + +C W VN +++ Sbjct: 521 NISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISK 580 Query: 545 PRLQLSNGNR---TLTLFNVTRNDARAYVCGIQN-SVSANRSDPVTLDVLYG 592 ++ ++ + LT+ NV+ D+ Y C +N + + Sbjct: 581 QKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQ 632 Score = 110 bits (273), Expect = 3e-24, Method: Composition-based stats. Identities = 93/541 (17%), Positives = 161/541 (29%), Gaps = 110/541 (20%) Query: 248 SYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIP------------------NI 289 ++G+ L+L C A + W + + ++ L I Sbjct: 16 IMQAGQTLHLQCRG----EAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTA 71 Query: 290 TVNNSGSYTCQAHNSDTGLNRTTVTTITV----YAEPPKPFITS-NNSNPVEDEDAVALT 344 N++G Y+C+ T + T + I + P + + + + + Sbjct: 72 QANHTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIP 131 Query: 345 CEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRT-LTLLSVTRNDVGPYECGIQ------- 396 C N T + ++ D+R + + T ++G C Sbjct: 132 CRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYK 191 Query: 397 -NKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAAS--NPPAQYSWLIDG 453 N L+ ++ +I D +P G L L+C A + N Q +W Sbjct: 192 TNYLTHRQTNTII-------DVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPD 244 Query: 454 NIQQHTQE-----------------LFISNITEKNSGLYTCQANNSASGHSRTTVKTITV 496 + L I + K+ GLYTC+ + S S T I Sbjct: 245 EKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYD 304 Query: 497 SAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTT-YLWWVNGQSLPVSPRLQLSNGNRT 555 A + + V K + + + +A + +W +G L+ G + Sbjct: 305 KAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRG-YS 363 Query: 556 LTLFNVTRNDARAYVCGIQNSVSAN-RSDPVTLDVLYGPDTP---IISPPDSSYLS-GAN 610 L + +VT DA Y + S ++ TL V P + S PD + G+ Sbjct: 364 LIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSR 423 Query: 611 LNLSCHSASNPSPQYSWR-----INGIPQ-----QHTQVLFIAKITPNN----------- 649 L+C + P P W N + + FI N Sbjct: 424 QILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRM 483 Query: 650 --------------------NGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSAGATV 689 +G Y C SN +I IT +G L T Sbjct: 484 AIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTE 543 Query: 690 G 690 G Sbjct: 544 G 544 Score = 104 bits (258), Expect = 2e-22, Method: Composition-based stats. Identities = 111/630 (17%), Positives = 187/630 (29%), Gaps = 135/630 (21%) Query: 160 KDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGN---------RTLTLFNVTRNDT 210 + C +A + W + S RL ++ TLTL N T Sbjct: 20 GQTLHLQC---RGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHT 76 Query: 211 ASYKCE--TQNPVSARRSDSVILNVLYGPDAPTISPLNTSYR-----SGENLNLSCHAAS 263 Y C+ + ++S I + P + + G L + C S Sbjct: 77 GFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTS 136 Query: 264 NPPAQYSWFV--------NGTFQ--QSTQELFIPNITVNNSGSYTCQAH------NSDTG 307 P + +G S + I N T G TC+A ++ Sbjct: 137 -PNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYL 195 Query: 308 LNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYL---WWV-NNQSL 363 +R T T I V P+P + + L C T + W + ++ Sbjct: 196 THRQTNTIIDVQISTPRPV-------KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNK 248 Query: 364 PVSPRLQLSNDNRT-------LTLLSVTRNDVGPYECGIQN-------KLSVDHSDPVIL 409 S R ++ N LT+ + D G Y C +++ SV D + Sbjct: 249 RASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFI 308 Query: 410 NVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQ--------E 461 V + + + + LS + P + WL DG Sbjct: 309 TVKHRKQQVLETVAGK-----RSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYS 363 Query: 462 LFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSI-----SSNNSKPVEDK 516 L I ++TE+++G YT + S T T+ + S + Sbjct: 364 LIIKDVTEEDAGNYTILLSIKQSNV--FKNLTATLIVNVKPQIYEKAVSSFPDPALYPLG 421 Query: 517 DAVAFTCEPEAQN-TTYLWW-----------------VNGQSLPVS-------------P 545 TC T W+ N +S + Sbjct: 422 SRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQ 481 Query: 546 RLQLSNGNRTL--TLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDS 603 R+ + G + TL + Y+C N V ++ + P+ ++ Sbjct: 482 RMAIIEGKNKMASTLVVADSRISGIYICIASNKVG-TVGRNISFYITDVPNGFHVNLEKM 540 Query: 604 SYLSGANLNLSCHSAS---------------NPSPQYSWRIN--GIPQQHTQVLF--IAK 644 G +L LSC N + YS I ++H+ L I Sbjct: 541 P-TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMN 599 Query: 645 ITPNNNGTYACFVSNLATGRNNSIVKSITV 674 ++ ++GTYAC N+ TG K IT+ Sbjct: 600 VSLQDSGTYACRARNVYTGEEILQKKEITI 629 Score = 91.5 bits (225), Expect = 1e-18, Method: Composition-based stats. Identities = 60/364 (16%), Positives = 111/364 (30%), Gaps = 70/364 (19%) Query: 96 SGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSI--SSNN 153 S + L I + D G YT V T +Y + Sbjct: 259 SNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTS-VHIYDKAFITVKHRKQQV 317 Query: 154 SKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASY 213 + V K + + + + + + W+ + + +L + +VT D +Y Sbjct: 318 LETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNY 377 Query: 214 KCET---QNPVSARRSDSVILNVLYGPDAPTIS--PLNTSYRSGENLNLSCHAASNPPAQ 268 Q+ V + ++I+NV +S P Y G L+C A P Sbjct: 378 TILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPT 437 Query: 269 YSWF---------------------------------VNGTFQQSTQELFIPN-----IT 290 WF + Q + N + Sbjct: 438 IKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLV 497 Query: 291 VNN---SGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEP 347 V + SG Y C A N + R IT + P F N + + + L+C Sbjct: 498 VADSRISGIYICIASNKVGTVGRNISFYIT---DVPNGF-HVNLEKMPTEGEDLKLSCTV 553 Query: 348 EI---QNTTYL-----------WWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYEC 393 ++ T++ + ++ Q + ++ + LT+++V+ D G Y C Sbjct: 554 NKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSI---TLNLTIMNVSLQDSGTYAC 610 Query: 394 GIQN 397 +N Sbjct: 611 RARN 614 Score = 86.5 bits (212), Expect = 3e-17, Method: Composition-based stats. Identities = 64/388 (16%), Positives = 106/388 (27%), Gaps = 64/388 (16%) Query: 319 YAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDN--- 375 +P + + + + L C + W + S RL ++ Sbjct: 3 LKDPELSLKGTQHIM--QAGQTLHLQC---RGEAAHKWSLPEMVSKESERLSITKSACGR 57 Query: 376 ------RTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYY-- 427 TLTL + N G Y C L+V S + Sbjct: 58 NGKQFCSTLTLNTAQANHTGFYSC---KYLAVPTSKKKETESAIYIFISDTGRPFVEMYS 114 Query: 428 --------RPGVNLSLSCHAASNPPAQYSWLI--------DGNIQQHTQE--LFISNITE 469 G L + C ++P + DG ISN T Sbjct: 115 EIPEIIHMTEGRELVIPCRV-TSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATY 173 Query: 470 KNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPE--- 526 K GL TC+A +T T + + IS+ + + C Sbjct: 174 KEIGLLTCEAT-VNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPL 232 Query: 527 AQNTTYLWW---VNGQSLPVSPRLQLSNGNRT-----LTLFNVTRNDARAYVCGIQNSVS 578 W + V R+ SN + LT+ + D Y C +++ Sbjct: 233 NTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRS--G 290 Query: 579 ANRSDPVTLDVLYGPDTPIISPPDS----SYLSGANLNLSCHSASNPSPQYSWRINGIPQ 634 + T +Y + + + LS + PSP+ W +G+P Sbjct: 291 PSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPA 350 Query: 635 QHTQ--------VLFIAKITPNNNGTYA 654 L I +T + G Y Sbjct: 351 TEKSARYLTRGYSLIIKDVTEEDAGNYT 378 Score = 73.8 bits (179), Expect = 3e-13, Method: Composition-based stats. Identities = 54/292 (18%), Positives = 94/292 (32%), Gaps = 59/292 (20%) Query: 83 VIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDL---VNEEATGQFR 139 V+ + P S R + SL+I+++ + D G YT+ + N AT Sbjct: 341 VVWLKDGLPATEKSARYL-TRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVN 399 Query: 140 VYPELPKPSISS-NNSKPVEDKDAVAFTCEPETQDATYLWWV-----------------N 181 V P++ + ++SS + TC + W N Sbjct: 400 VKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSN 459 Query: 182 NQSLPV--------------SPRLQLSNGNRTL--TLFNVTRNDTASYKCETQNPVSARR 225 N+ + + R+ + G + TL + Y C N V Sbjct: 460 NEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGT-V 518 Query: 226 SDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQST---- 281 ++ + P+ ++ GE+L LSC +W + T T Sbjct: 519 GRNISFYITDVPNGFHVNLEKMPTE-GEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYS 577 Query: 282 ---------------QELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITV 318 L I N+++ +SG+Y C+A N TG IT+ Sbjct: 578 ISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQKKEITI 629 >4KC3-B nrPDB Length = 309 Score = 126 bits (315), Expect = 5e-29, Method: Composition-based stats. Identities = 53/291 (18%), Positives = 95/291 (32%), Gaps = 47/291 (16%) Query: 159 DKDAVAFTCEPETQDATYL-WWVN--NQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKC 215 + +A+ C + + + + W+ + N+S+P R ++ + L D+ Y C Sbjct: 10 ENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTC 69 Query: 216 ETQNPVSARRSDSVILNVLYGPDAPTIS-----PLNTSYRSGENLNLSCHAAS--NPPAQ 268 ++P + + NV + +T S +N + C N A Sbjct: 70 IVRSPT---FNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWTAP 126 Query: 269 YSWFVNGT------FQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAE- 321 WF N ++ L I N+ ++G YTC+ +++ G N + T + + Sbjct: 127 LEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKD 186 Query: 322 -------PPKPFITSNNSNPVEDEDAVALTCEPEIQNTTY-----LWWVN-----NQSLP 364 P N VE LTC T LW +N + P Sbjct: 187 EQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEP 246 Query: 365 -----VSPRLQLSND----NRTLTLLSVTRNDVGP-YECGIQNKLSVDHSD 405 SN + L + V D+ Y+C N + Sbjct: 247 RIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHT 297 Score = 69.6 bits (168), Expect = 4e-12, Method: Composition-based stats. Identities = 57/288 (19%), Positives = 96/288 (33%), Gaps = 45/288 (15%) Query: 337 DEDAVALTCEPEIQNTTYLWWV---NNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYEC 393 + +A+ + C + + + + W N+S+P R ++ + L L D G Y C Sbjct: 10 ENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTC 69 Query: 394 GIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRP----GVNLSLSCHAAS--NPPAQY 447 +++ + + + + + Y P Y Y N + C N A Sbjct: 70 IVRSP-TFNRTGYANVTI-YKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPL 127 Query: 448 SWLID------GNIQQHTQELFISNITEKNSGLYTC--QANNSASGHSRTTVKTITVSAE 499 W + + H L I N+ +++G YTC N + + +S T ++ TV E Sbjct: 128 EWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDE 187 Query: 500 LP---KPSISSNNS---KPVEDKDAVAFTCEP-----EAQNTTYLWWVNGQSL------- 541 P I + K VE TC LW +NG + Sbjct: 188 QGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPR 247 Query: 542 ---PVSPRLQLSNG----NRTLTLFNVTRND-ARAYVCGIQNSVSANR 581 SNG + L + +V D Y C N R Sbjct: 248 IQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRR 295 Score = 61.9 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 47/246 (19%), Positives = 71/246 (28%), Gaps = 33/246 (13%) Query: 426 YYRPGVNLSLSCHAASNPPAQYSWLI----DGNIQQHTQELFIS-------NITEKNSGL 474 + L + C P W Q +F S +SG+ Sbjct: 7 WGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGI 66 Query: 475 YTCQANNSASGHSRTTVKTITVS-AELPKPSISSNNSKPVEDKDAVAFTCEPEAQN---T 530 YTC + + TI ++ P ++ +K++ C Sbjct: 67 YTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNS-KIYCPTIDLYNWTA 125 Query: 531 TYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCG-IQNSVSANRSDPVTLDV 589 W+ N Q+L S L + NV DA Y C I N AN S T Sbjct: 126 PLEWFKNCQALQGSRY---RAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSF 182 Query: 590 LYGPD-----TPIISPPDSS----YLSGANLNLSCHSASNP----SPQYSWRINGIPQQH 636 + P+I P + G N NL+C + W++NG Sbjct: 183 TVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITD 242 Query: 637 TQVLFI 642 I Sbjct: 243 FGEPRI 248 Score = 56.1 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 31/172 (18%), Positives = 61/172 (35%), Gaps = 23/172 (13%) Query: 515 DKDAVAFTCEPEAQNT-TYLWW--VNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVC 571 + +A+ C + + + T W+ +S+P R ++ + L D+ Y C Sbjct: 10 ENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTC 69 Query: 572 GIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQY------ 625 +++ + NR+ + + + PD YL + ++ S ++ P Sbjct: 70 IVRSP-TFNRTGYANVTIY--KKQSDCNVPD--YLMYSTVSGSEKNSKIYCPTIDLYNWT 124 Query: 626 ---SWRINGIPQQ------HTQVLFIAKITPNNNGTYACFVSNLATGRNNSI 668 W N Q H L I + + G Y C + G N S+ Sbjct: 125 APLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSV 176 Score = 55.3 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 42/183 (22%), Positives = 65/183 (35%), Gaps = 25/183 (13%) Query: 114 QNDTGFYTLHVIKSDLVNEEATGQFRVYPE-----LPKPSISSNNSKPVEDKDAVAFTCE 168 D+G YT V +S N +Y + +P + S S ++ T + Sbjct: 61 VADSGIYTCIV-RSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTID 119 Query: 169 PETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCE-------TQNPV 221 A W+ N Q+L S + L + NV D Y C+ V Sbjct: 120 LYNWTAPLEWFKNCQALQGS---RYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSV 176 Query: 222 SARRSDSVI----LNVLYGPDAPTISPLNTSYRSGENLNLSCHA-ASNPP---AQYSWFV 273 +A RS +V ++ AP + + G+N NL+C A A W + Sbjct: 177 TATRSFTVKDEQGFSLFPVIGAPAQNEIK-EVEIGKNANLTCSACFGKGTQFLAAVLWQL 235 Query: 274 NGT 276 NGT Sbjct: 236 NGT 238 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 35/163 (21%), Positives = 50/163 (30%), Gaps = 33/163 (20%) Query: 94 AYSGREIIYPNASLLIQNIIQNDTGFYTL-----------HVIKSDLVNEEATGQFRVYP 142 A G + L+I N++ D G YT V + + F ++P Sbjct: 135 ALQGSRYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFP 194 Query: 143 ELPKPSISSNNSKPVEDKDAVAFTCEPETQDAT-----YLWWVNNQSL--PVSPRLQLSN 195 + P+ N K VE TC T LW +N + PR+Q Sbjct: 195 VIGAPA--QNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEE 252 Query: 196 GNR------------TLTLFNVTRNDTAS-YKCETQNPVSARR 225 G L + +V D Y C N RR Sbjct: 253 GQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRR 295 >1EPF-A nrPDB Length = 191 Score = 115 bits (287), Expect = 7e-26, Method: Composition-based stats. Identities = 40/182 (21%), Positives = 67/182 (36%), Gaps = 26/182 (14%) Query: 43 FNVAEGKEVLLLVHNLPQHLFGYSWY--KGERVDGNRQIIGYVIGTQQATPGPAYSGREI 100 +V E K L V + SW+ GE++ N+Q I V + Sbjct: 14 ISVGESKFFLCQVAGDAKDKDI-SWFSPNGEKLSPNQQRISVVWNDDDS----------- 61 Query: 101 IYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDK 160 ++L I N +D G Y V D EAT +++ +L + N P E K Sbjct: 62 ----STLTIYNANIDDAGIYKCVVTAEDGTQSEATVNVKIFQKL----MFKNAPTPQEFK 113 Query: 161 ---DAVAFTCEPETQDATYLWWVNNQSLPVSPR-LQLSNGNRTLTLFNVTRNDTASYKCE 216 DAV + T +W + + + + N L + + + D +Y+CE Sbjct: 114 EGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCE 173 Query: 217 TQ 218 + Sbjct: 174 GR 175 Score = 106 bits (264), Expect = 3e-23, Method: Composition-based stats. Identities = 32/186 (17%), Positives = 67/186 (36%), Gaps = 20/186 (10%) Query: 330 NNSNPVEDEDAVALTCEPEI-QNTTYLWWVNNQSLPVSPRLQL------SNDNRTLTLLS 382 + + ++ C+ + W + +SP Q +D+ TLT+ + Sbjct: 9 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLTIYN 68 Query: 383 VTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASN 442 +D G Y+C + + V + + + +P+ ++ G + + C S+ Sbjct: 69 ANIDDAGIYKCVVTAEDGTQSEATVNVKI-FQKLMFKNAPTPQEFKEGEDAVIVCDVVSS 127 Query: 443 PPAQYSWLIDGN---IQQHTQELFISN-------ITEKNSGLYTCQANNSASGHSRTTVK 492 P W G +++ + + +SN I + + G Y C+ A G K Sbjct: 128 LPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGE--INFK 185 Query: 493 TITVSA 498 I V Sbjct: 186 DIQVIV 191 Score = 76.5 bits (186), Expect = 4e-14, Method: Composition-based stats. Identities = 32/173 (18%), Positives = 55/173 (31%), Gaps = 22/173 (12%) Query: 148 SISSNNSKPVEDKDAVAFTCEPETQDA-TYLWWVN---NQSLPVSPRLQLSNGNR---TL 200 + S V ++ F C+ + W + + P R+ + + TL Sbjct: 7 IVPSQGEISV--GESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTL 64 Query: 201 TLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPD-APTISPLNTSYRSGENLNLSC 259 T++N +D YKC +NV +P ++ GE+ + C Sbjct: 65 TIYNANIDDAGIYKCVVT--AEDGTQSEATVNVKIFQKLMFKNAPTPQEFKEGEDAVIVC 122 Query: 260 HAASNPPAQYSWFVNGT----------FQQSTQELFIPNITVNNSGSYTCQAH 302 S+ P W G S L I I + G+Y C+ Sbjct: 123 DVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGR 175 Score = 74.2 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 31/183 (16%), Positives = 55/183 (30%), Gaps = 22/183 (12%) Query: 242 ISPLNTSYRSGENLNLSCHAASNPP-AQYSWFV-NGTFQ-------------QSTQELFI 286 I P GE+ C A + SWF NG + L I Sbjct: 7 IVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLTI 66 Query: 287 PNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCE 346 N ++++G Y C D + TV K T + + + C+ Sbjct: 67 YNANIDDAGIYKCVVTAEDGTQSEATVNVKIFQKLMFKNAPTPQEFK---EGEDAVIVCD 123 Query: 347 PEIQNTTYLWWVNNQSLPVSPR--LQLSNDNRTLTLLSVTRNDVGPYECGIQ--NKLSVD 402 + W + + + + N L + + + D G Y C + + ++ Sbjct: 124 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEIN 183 Query: 403 HSD 405 D Sbjct: 184 FKD 186 Score = 73.0 bits (177), Expect = 4e-13, Method: Composition-based stats. Identities = 30/166 (18%), Positives = 56/166 (33%), Gaps = 20/166 (12%) Query: 508 NNSKPVEDKDAVAFTCEPEA--QNTTYLWWV-NGQSLPVSPRLQ----LSNGNRTLTLFN 560 + + ++ F C+ ++ W+ NG+ L + + + + TLT++N Sbjct: 9 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLTIYN 68 Query: 561 VTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS-PPDSSYLSGANLNLSCHSAS 619 +DA Y C + T++V + P + G + + C S Sbjct: 69 ANIDDAGIYKCVVTAEDG--TQSEATVNVKIFQKLMFKNAPTPQEFKEGEDAVIVCDVVS 126 Query: 620 NPSPQYSWRING----------IPQQHTQVLFIAKITPNNNGTYAC 655 + P W+ G L I I + GTY C Sbjct: 127 SLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC 172 Score = 71.1 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 25/169 (14%), Positives = 48/169 (28%), Gaps = 20/169 (11%) Query: 420 ISPSYTYYRPGVNLSLSCHAASNPP-AQYSWL-IDGNI-------------QQHTQELFI 464 I PS G + C A + SW +G + L I Sbjct: 7 IVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLTI 66 Query: 465 SNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCE 524 N ++G+Y C + T+ V ++ + ++ + C+ Sbjct: 67 YNANIDDAGIYKCVVTAEDG---TQSEATVNVKIFQKLMFKNAPTPQEFKEGEDAVIVCD 123 Query: 525 -PEAQNTTYLW-WVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVC 571 + T +W + + N L + + + D Y C Sbjct: 124 VVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRC 172 Score = 39.9 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 18/88 (20%), Positives = 28/88 (31%), Gaps = 15/88 (17%) Query: 597 IISPPDSSYLSGANLNLSCHSASNPSPQ-YSWRI-NG---IPQQ----------HTQVLF 641 I P G + C A + + SW NG P Q + L Sbjct: 6 DIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLT 65 Query: 642 IAKITPNNNGTYACFVSNLATGRNNSIV 669 I ++ G Y C V+ ++ + V Sbjct: 66 IYNANIDDAGIYKCVVTAEDGTQSEATV 93 >5B22-A nrPDB Length = 211 Score = 105 bits (262), Expect = 6e-23, Method: Composition-based stats. Identities = 44/210 (20%), Positives = 70/210 (33%), Gaps = 37/210 (17%) Query: 239 APTISPLNTSYRSGENLNLSCHAASNPP---------------------AQYSWFVNGTF 277 I + + G+N++L C N QY + V G + Sbjct: 1 PSIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSTQTVAVHHPQYGFSVQGDY 60 Query: 278 QQS---------TQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFIT 328 Q + + NI ++SG Y C+A G N + TT+TV EP I Sbjct: 61 QGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLG-NAQSSTTVTVLVEPTVSLIK 119 Query: 329 SNNSNPVEDEDAVALTC-EPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTL---TLLSVT 384 +S + VA C + + W + S N+ T+ L T Sbjct: 120 GPDSLIDGGNETVAAVCVAATGKPVAQIDWEGDLGEMESSTTSFPNETATIVSQYKLFPT 179 Query: 385 RNDVG-PYECGIQN-KLSVDHSDPVILNVL 412 R G C +++ L D IL++ Sbjct: 180 RFARGRRITCVVKHPALEKDIRYSFILDIQ 209 Score = 97.7 bits (241), Expect = 1e-20, Method: Composition-based stats. Identities = 27/140 (19%), Positives = 45/140 (32%), Gaps = 9/140 (6%) Query: 458 HTQELFISNITEKNSGLYTCQA-NNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDK 516 + + + NI +SG Y C+A +T T+TV E I +S Sbjct: 72 NDATITLHNIGFSDSGKYICKAVTFPLGNAQSST--TVTVLVEPTVSLIKGPDSLIDGGN 129 Query: 517 DAVAFTC-EPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTL----TLFNVTRNDARAYVC 571 + VA C + + W S N T+ LF R C Sbjct: 130 ETVAAVCVAATGKPVAQIDWEGDLGEMESSTTSFPNETATIVSQYKLFPTRFARGRRITC 189 Query: 572 GIQNS-VSANRSDPVTLDVL 590 +++ + + LD+ Sbjct: 190 VVKHPALEKDIRYSFILDIQ 209 Score = 55.3 bits (131), Expect = 9e-08, Method: Composition-based stats. Identities = 26/105 (24%), Positives = 39/105 (37%), Gaps = 8/105 (7%) Query: 528 QNTTYLWWVNGQSLPVSPRLQLSNG---NRTLTLFNVTRNDARAYVCGIQNSVSANRSDP 584 + Y + V G R+ N + T+TL N+ +D+ Y+C N Sbjct: 48 HHPQYGFSVQGDY---QGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSS 104 Query: 585 VTLDVLYGPDTPIISPPDSSYLSG-ANLNLSC-HSASNPSPQYSW 627 T+ VL P +I PDS G + C + P Q W Sbjct: 105 TTVTVLVEPTVSLIKGPDSLIDGGNETVAAVCVAATGKPVAQIDW 149 Score = 46.5 bits (108), Expect = 5e-05, Method: Composition-based stats. Identities = 33/196 (16%), Positives = 62/196 (31%), Gaps = 14/196 (7%) Query: 46 AEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPA-YSGREIIYP- 103 + + L+ + + + SW E++ G V Q Y GR + Sbjct: 14 GKNVSLKCLIE-VNETITQISW---EKIHGKSTQTVAVHHPQYGFSVQGDYQGRVLFKNY 69 Query: 104 ---NASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDK 160 +A++ + NI +D+G Y + L N +++ V E I +S Sbjct: 70 SLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGN 129 Query: 161 DAVAFTCE-PETQDATYLWWVNNQSLPVSPRLQLSNGNRTL----TLFNVTRNDTASYKC 215 + VA C + + W + S N T+ LF C Sbjct: 130 ETVAAVCVAATGKPVAQIDWEGDLGEMESSTTSFPNETATIVSQYKLFPTRFARGRRITC 189 Query: 216 ETQNPVSARRSDSVIL 231 ++P + + Sbjct: 190 VVKHPALEKDIRYSFI 205 Score = 39.2 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 29/107 (27%), Positives = 41/107 (38%), Gaps = 5/107 (4%) Query: 194 SNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSG- 252 S + T+TL N+ +D+ Y C+ S + VL P I ++ G Sbjct: 70 SLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGN 129 Query: 253 ENLNLSCHAA-SNPPAQYSWFVN-GTFQQSTQELFIPNITVNNSGSY 297 E + C AA P AQ W + G + ST PN T Y Sbjct: 130 ETVAAVCVAATGKPVAQIDWEGDLGEMESSTTS--FPNETATIVSQY 174 Score = 38.4 bits (87), Expect = 0.012, Method: Composition-based stats. Identities = 20/81 (24%), Positives = 31/81 (38%), Gaps = 2/81 (2%) Query: 374 DNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPG-VN 432 ++ T+TL ++ +D G Y C + + VL P I + G Sbjct: 72 NDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNET 131 Query: 433 LSLSCHAA-SNPPAQYSWLID 452 ++ C AA P AQ W D Sbjct: 132 VAAVCVAATGKPVAQIDWEGD 152 >2XY2-A nrPDB Length = 189 Score = 102 bits (254), Expect = 4e-22, Method: Composition-based stats. Identities = 45/210 (21%), Positives = 77/210 (36%), Gaps = 35/210 (16%) Query: 34 AKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWY--KGERVDGNRQIIGYVIGTQQATP 91 +++ +V E K P+ + WY +GE++ ++++ G Sbjct: 5 VTISLSKVELSVGESKFFTCTAIGEPESI---DWYNPQGEKIISTQRVVVQKEGV----- 56 Query: 92 GPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPEL-PKPSIS 150 + L I N D G Y + +EAT +Y +L + +S Sbjct: 57 ------------RSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVS 104 Query: 151 SNNSKPVEDKDAVAFTCEPETQDATYLWW--VNNQSLPVSPRLQLSNGNRTLTLFNVTRN 208 K ED + V C + A + W N + +S N L + N+ ++ Sbjct: 105 PQEFKQGEDAEVV---CRVSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKS 161 Query: 209 DTASYKCETQNPVSAR-----RSDSVILNV 233 D Y+CE + V AR R VI+NV Sbjct: 162 DEGIYRCEGR--VEARGEIDFRDIIVIVNV 189 Score = 96.2 bits (237), Expect = 5e-20, Method: Composition-based stats. Identities = 37/184 (20%), Positives = 66/184 (35%), Gaps = 16/184 (8%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFV-NGTFQQST-----------QELFIPN 288 TIS GE+ +C A P W+ G ST L I N Sbjct: 6 TISLSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYN 64 Query: 289 ITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPE 348 + ++G Y CQA ++ TV + ++ ED + V Sbjct: 65 ANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSP 124 Query: 349 IQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECG--IQNKLSVDHSDP 406 ++L+ N + +S N L +L++ ++D G Y C ++ + +D D Sbjct: 125 APAVSWLYH-NEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDI 183 Query: 407 VILN 410 +++ Sbjct: 184 IVIV 187 Score = 88.1 bits (216), Expect = 1e-17, Method: Composition-based stats. Identities = 30/176 (17%), Positives = 57/176 (32%), Gaps = 16/176 (9%) Query: 338 EDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRT---LTLLSVTRNDVGPYECG 394 ++ TC + + W+ +S + + LT+ + D G Y C Sbjct: 17 GESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQ 76 Query: 395 IQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGN 454 + V+L + Y S ++ G + + C +S+P SWL Sbjct: 77 ATDAKGQTQEATVVLEI-YQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNE 135 Query: 455 I---QQHTQELFI-------SNITEKNSGLYTCQANNSASGHSRTTVKTITVSAEL 500 + + NI + + G+Y C+ A G + I V + Sbjct: 136 EVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGE--IDFRDIIVIVNV 189 Score = 67.3 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 29/154 (18%), Positives = 59/154 (38%), Gaps = 16/154 (10%) Query: 516 KDAVAFTCEPEAQNTTYLWWV-NGQSLPVSPRLQL--SNGNRTLTLFNVTRNDARAYVCG 572 ++ FTC + + W+ G+ + + R+ + LT++N DA Y C Sbjct: 17 GESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQ 76 Query: 573 IQNSVSANRSDPVTLDVLYGPDT-PIISPPDSSYLSGANLNLSCHSASNPSPQYSWRING 631 ++ + V L++ ++SP + G + + C +S+P+P SW + Sbjct: 77 ATDAKGQTQEATVVLEIYQKLTFREVVSP--QEFKQGEDAEVVCRVSSSPAPAVSWLYHN 134 Query: 632 IPQ---QHTQVLFIA-------KITPNNNGTYAC 655 + +A I ++ G Y C Sbjct: 135 EEVTTISDNRFAMLANNNLQILNINKSDEGIYRC 168 Score = 64.2 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 32/167 (19%), Positives = 55/167 (32%), Gaps = 18/167 (10%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQYSWL-IDGNIQQH-----------TQELFISN 466 TIS S G + +C A P W G L I N Sbjct: 6 TISLSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYN 64 Query: 467 ITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPE 526 +++G+Y CQA + A G ++ + + +L + S + + C Sbjct: 65 ANIEDAGIYRCQATD-AKGQTQEATVVLEIYQKLTFREVVSPQEF--KQGEDAEVVCRVS 121 Query: 527 AQN-TTYLW-WVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVC 571 + W + N + +S N L + N+ ++D Y C Sbjct: 122 SSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRC 168 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 14/88 (15%), Positives = 21/88 (23%), Gaps = 19/88 (21%) Query: 598 ISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHT---------------QVLFI 642 IS G + +C + P W PQ L I Sbjct: 7 ISLSKVELSVGESKFFTCTAIGEPE-SIDWYN---PQGEKIISTQRVVVQKEGVRSRLTI 62 Query: 643 AKITPNNNGTYACFVSNLATGRNNSIVK 670 + G Y C ++ + V Sbjct: 63 YNANIEDAGIYRCQATDAKGQTQEATVV 90 >3BFO-A nrPDB Length = 91 Score = 95.4 bits (235), Expect = 8e-20, Method: Composition-based stats. Identities = 20/78 (25%), Positives = 35/78 (44%), Gaps = 2/78 (2%) Query: 597 IISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQH--TQVLFIAKITPNNNGTYA 654 + P + G+ L L C + +P P Y W N +P H ++ + + + GTY Sbjct: 7 CVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYW 66 Query: 655 CFVSNLATGRNNSIVKSI 672 C V N +++ V+ I Sbjct: 67 CHVYNDRDSQDSKKVEII 84 Score = 79.2 bits (193), Expect = 5e-15, Method: Composition-based stats. Identities = 20/79 (25%), Positives = 33/79 (41%), Gaps = 2/79 (2%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTF-QQSTQELF-IPNITVNNSGSYT 298 + P + G L L C A +P Y WF N T++L+ +P + + + G+Y Sbjct: 7 CVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYW 66 Query: 299 CQAHNSDTGLNRTTVTTIT 317 C +N + V I Sbjct: 67 CHVYNDRDSQDSKKVEIII 85 Score = 52.2 bits (123), Expect = 7e-07, Method: Composition-based stats. Identities = 17/77 (22%), Positives = 27/77 (35%), Gaps = 2/77 (2%) Query: 420 ISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQE--LFISNITEKNSGLYTC 477 + P+ PG L L C A +P Y W + H + + + ++ G Y C Sbjct: 8 VEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWC 67 Query: 478 QANNSASGHSRTTVKTI 494 N V+ I Sbjct: 68 HVYNDRDSQDSKKVEII 84 Score = 35.7 bits (80), Expect = 0.080, Method: Composition-based stats. Identities = 11/73 (15%), Positives = 18/73 (24%), Gaps = 8/73 (10%) Query: 160 KDAVAFTCEPETQDAT-YLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ 218 + C Y W+ N L + L +Y C Sbjct: 18 GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDL-------EHQGTYWCHVY 70 Query: 219 NPVSARRSDSVIL 231 N ++ S V + Sbjct: 71 NDRDSQDSKKVEI 83 Score = 33.4 bits (74), Expect = 0.40, Method: Composition-based stats. Identities = 13/82 (15%), Positives = 22/82 (26%), Gaps = 6/82 (7%) Query: 330 NNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVG 389 S + + L C + W N+ +L + V G Sbjct: 10 PTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLY------MVPYVDLEHQG 63 Query: 390 PYECGIQNKLSVDHSDPVILNV 411 Y C + N S V + + Sbjct: 64 TYWCHVYNDRDSQDSKKVEIII 85 >2L7J-A nrPDB Length = 95 Score = 83.8 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 29/94 (30%), Positives = 38/94 (40%), Gaps = 7/94 (7%) Query: 409 LNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQ-YSW------LIDGNIQQHTQE 461 LNV Y P+ +Y ++ L+C A +NPPA Y W L G Q+ Sbjct: 1 LNVQYEPEVTIEGFDGNWYLQRTDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTL 60 Query: 462 LFISNITEKNSGLYTCQANNSASGHSRTTVKTIT 495 F IT +G Y C+A N S IT Sbjct: 61 FFRGPITYSLAGTYICEATNPIGTRSGQVEVNIT 94 Score = 68.8 bits (166), Expect = 7e-12, Method: Composition-based stats. Identities = 26/94 (27%), Positives = 42/94 (44%), Gaps = 7/94 (7%) Query: 587 LDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQ-YSW------RINGIPQQHTQV 639 L+V Y P+ I + YL ++ L+C + +NP Y W G+ Q+ + Sbjct: 1 LNVQYEPEVTIEGFDGNWYLQRTDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTL 60 Query: 640 LFIAKITPNNNGTYACFVSNLATGRNNSIVKSIT 673 F IT + GTY C +N R+ + +IT Sbjct: 61 FFRGPITYSLAGTYICEATNPIGTRSGQVEVNIT 94 Score = 46.1 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 9/95 (9%) Query: 231 LNVLYGPDAPTISPLNTS-YRSGENLNLSCHAASNPPAQ-YSWFV-NGTF----QQSTQE 283 LNV Y P+ TI + + Y ++ L+C A +NPPA Y W NG+ + + Sbjct: 1 LNVQYEPEV-TIEGFDGNWYLQRTDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRT 59 Query: 284 LFIPN-ITVNNSGSYTCQAHNSDTGLNRTTVTTIT 317 LF IT + +G+Y C+A N + IT Sbjct: 60 LFFRGPITYSLAGTYICEATNPIGTRSGQVEVNIT 94 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 23/92 (25%), Positives = 37/92 (40%), Gaps = 8/92 (8%) Query: 501 PKPSISSNNSKPVEDKDAVAFTCEPEAQNTT--YLWWVNGQSLPVSPRLQLSNGNRTLTL 558 P+ +I + + V TC+ +A Y W SLP + NRTL Sbjct: 7 PEVTIEGFDGNWYLQRTDVKLTCKADANPPATEYHWTTLNGSLPKG----VEAQNRTLFF 62 Query: 559 F-NVTRNDARAYVCGIQNSVSANRSDPVTLDV 589 +T + A Y+C N + RS V +++ Sbjct: 63 RGPITYSLAGTYICEATNPIG-TRSGQVEVNI 93 Score = 38.0 bits (86), Expect = 0.014, Method: Composition-based stats. Identities = 22/75 (29%), Positives = 31/75 (41%), Gaps = 8/75 (10%) Query: 163 VAFTCEPETQDAT--YLWWVNNQSLPVSPRLQLSNGNRTLTLFN-VTRNDTASYKCETQN 219 V TC+ + Y W N SLP + NRTL +T + +Y CE N Sbjct: 25 VKLTCKADANPPATEYHWTTLNGSLP----KGVEAQNRTLFFRGPITYSLAGTYICEATN 80 Query: 220 PVSARRSDSVILNVL 234 P+ R V +N+ Sbjct: 81 PIGTRSGQ-VEVNIT 94 >2X1X-R nrPDB Length = 213 Score = 79.2 bits (193), Expect = 6e-15, Method: Composition-based stats. Identities = 43/212 (20%), Positives = 67/212 (31%), Gaps = 33/212 (15%) Query: 319 YAEPPKPFITSNNSNPV---EDEDAVALTCEPEIQNTTYLWWV---NNQSLPVSPRLQLS 372 Y P ++ + V + C I N + +P R+ Sbjct: 2 YRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWD 61 Query: 373 NDNRTLTLLSVTRNDVGPYECGIQ-NKLSVDHSDPVILNVLYGPDDPTISPSY-TYYRPG 430 + T+ S + G C + N S +++ V Y D +SPS+ G Sbjct: 62 SKKGF-TIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVG 120 Query: 431 VNLSLSCHAAS--NPPAQYSWLIDGNIQQHT-------------------QELFISNITE 469 L L+C A + N ++W + QH L I +T Sbjct: 121 EKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTR 180 Query: 470 KNSGLYTCQANNSASGHSRTTVKTITVSAELP 501 + GLYTC A+ SG T E P Sbjct: 181 SDQGLYTCAAS---SGLMTKKNSTFVRVHEDP 209 Score = 58.0 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 20/104 (19%), Positives = 46/104 (44%), Gaps = 11/104 (10%) Query: 40 STPFNVAEGKEVLLLVHNLPQHLFG--YSWYKGERVDGNRQIIGYVIGTQQATPGPAYSG 97 S ++ G++++L + G ++W +++++ + TQ SG Sbjct: 112 SHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQ--------SG 163 Query: 98 REIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVY 141 E+ ++L I + ++D G YT S L+ ++ + RV+ Sbjct: 164 SEMKKFLSTLTIDGVTRSDQGLYTCAAS-SGLMTKKNSTFVRVH 206 Score = 49.2 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 37/212 (17%), Positives = 74/212 (34%), Gaps = 19/212 (8%) Query: 218 QNPVSARRSD-SVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGT 276 ++P A SD ++ + + + P S NLN+S A P ++ N Sbjct: 3 RSPFIASVSDQHGVVYITENKNKTVVIPCLGSI---SNLNVSLCAR-YPEKRFVPDGNRI 58 Query: 277 FQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVE 336 S + IP+ ++ +G C+A +D + V ++ ++ + Sbjct: 59 SWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELS 118 Query: 337 DEDAVALTCEPEIQ---------NTTYLWWVNNQSLPVSPRLQLSNDN----RTLTLLSV 383 + + L C + + + + + Q ++ TLT+ V Sbjct: 119 VGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGV 178 Query: 384 TRNDVGPYECGIQNKLSVDHSDPVILNVLYGP 415 TR+D G Y C + L + + V P Sbjct: 179 TRSDQGLYTCAASSGLMTK-KNSTFVRVHEDP 209 Score = 38.0 bits (86), Expect = 0.013, Method: Composition-based stats. Identities = 21/157 (13%), Positives = 50/157 (31%), Gaps = 15/157 (9%) Query: 445 AQYSWLIDGNIQQHTQE--LFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPK 502 + ++ DGN + I + +G+ C+A + + + V + Sbjct: 47 PEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYD 106 Query: 503 PSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGN--------- 553 +S ++ + + + C + + + +L N + Sbjct: 107 VVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEM 166 Query: 554 ----RTLTLFNVTRNDARAYVCGIQNSVSANRSDPVT 586 TLT+ VTR+D Y C + + ++ Sbjct: 167 KKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFV 203 Score = 37.2 bits (84), Expect = 0.024, Method: Composition-based stats. Identities = 29/189 (15%), Positives = 53/189 (28%), Gaps = 25/189 (13%) Query: 511 KPVEDKDAVAFTC--EPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARA 568 V C N + + + + T+ + + A Sbjct: 19 ITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGM 78 Query: 569 YVCGIQ-NSVSANRSDPVTLDVLYGPDTPIISPP-DSSYLSGANLNLSCHSAS--NPSPQ 624 C + N S + + V Y ++SP G L L+C + + N Sbjct: 79 VFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGID 138 Query: 625 YSWRINGIPQQHTQ-------------------VLFIAKITPNNNGTYACFVSNLATGRN 665 ++W QH + L I +T ++ G Y C S+ + Sbjct: 139 FNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKK 198 Query: 666 NSIVKSITV 674 NS + Sbjct: 199 NSTFVRVHE 207 Score = 36.8 bits (83), Expect = 0.031, Method: Composition-based stats. Identities = 22/144 (15%), Positives = 50/144 (34%), Gaps = 15/144 (10%) Query: 108 LIQNIIQNDTGFYTLHVIKSDLVNEE-ATGQFRVYPELPKPSISSNNSKPVEDKDAVAFT 166 I + + + G +D + V + +S ++ + + + Sbjct: 67 TIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLN 126 Query: 167 CEPETQ-------DATYLWWVNNQSLPVSPRLQLSNGNR------TLTLFNVTRNDTASY 213 C T+ + Y + V+ L+ +G+ TLT+ VTR+D Y Sbjct: 127 CTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLY 186 Query: 214 KCETQNPVSARRSDSVILNVLYGP 237 C + + +++ + + V P Sbjct: 187 TCAASSGLMTKKNST-FVRVHEDP 209 >3O4O-C nrPDB Length = 339 Score = 78.1 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 52/303 (17%), Positives = 92/303 (30%), Gaps = 52/303 (17%) Query: 159 DKDAVAFTCE-------PETQDATYLWWVNN---QSLPVSPRLQLSNGNRTLTLFNVTRN 208 + + VA C L W N +++P ++ + L L + Sbjct: 32 EGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQE 91 Query: 209 DTASYKCETQNPVSARRSDSVILNVLYGPDAPTISP-LNTSYRSGENLNLSCH-----AA 262 D+ +Y C T+N S S+ L V DA + L C Sbjct: 92 DSGTYVCTTRN-ASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTR 150 Query: 263 SNPPAQYSWFVNGTFQQSTQE----------LFIPNITVNNSGSYTCQAHNSDTGLNRTT 312 + W+ + E L + ++ + ++G Y C + G Sbjct: 151 DKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNI 210 Query: 313 VTTITVYAEPPKP-----FITSNNSNPVEDEDAVALTCEP---EIQNTTY-LWWVNNQSL 363 +I + + K I+ + + + C+ T LWW N + Sbjct: 211 TRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTH 270 Query: 364 PVS----------PRLQLSNDNRT-----LTLLSVTRNDV-GPYECGIQNKLSVDHSDPV 407 S PR + S +N L VTR D+ ++C + N LS Sbjct: 271 IESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTT 330 Query: 408 ILN 410 + Sbjct: 331 VKE 333 Score = 75.0 bits (182), Expect = 1e-13, Method: Composition-based stats. Identities = 58/296 (19%), Positives = 92/296 (31%), Gaps = 54/296 (18%) Query: 337 DEDAVALTCE-------PEIQNTTYLWWVNN---QSLPVSPRLQLSNDNRTLTLLSVTRN 386 + + VAL C + L W N +++P ++ + L LL + Sbjct: 32 EGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQE 91 Query: 387 DVGPYECGIQNKLSVDHSDPVILNVLYGPDD--PTISPSYTYYRPGVNLSLSC-----HA 439 D G Y C +N D + L V D P IS + L C Sbjct: 92 DSGTYVCTTRNASYCD-KMSIELRVFENTDAFLPFISY-PQILTLSTSGVLVCPDLSEFT 149 Query: 440 ASNPPAQYSWLIDGNI----------QQHTQELFISNITEKNSGLYTCQANNSASG---- 485 + W D + + T L + ++ +++G Y C + G Sbjct: 150 RDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYN 209 Query: 486 HSRTTVKTITVSAELPKPSISSN-NSKPVEDKDAVAFTCEP---EAQN-TTYLWWVNGQS 540 +R+ I E P I S + + C+ TT LWW + Sbjct: 210 ITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDT 269 Query: 541 LPVS----------PRLQLSNGNRT-----LTLFNVTRNDARA-YVCGIQNSVSAN 580 S PR + S N L VTR D + C + N++S Sbjct: 270 HIESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQ 325 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 33/185 (17%), Positives = 60/185 (32%), Gaps = 29/185 (15%) Query: 515 DKDAVAFTCE-------PEAQN-TTYLWWVNG--QSLPVSPRLQLSNGNRTLTLFNVTRN 564 + + VA C W N +++P ++ + L L + Sbjct: 32 EGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQE 91 Query: 565 DARAYVCGIQNSVSANRSDPVTLDVLYGPDT--PIISPPDSSYLSGANLNLSCHSAS--- 619 D+ YVC +N+ ++ + L V D P IS P + L C S Sbjct: 92 DSGTYVCTTRNASYCDK-MSIELRVFENTDAFLPFISYP-QILTLSTSGVLVCPDLSEFT 149 Query: 620 --NPSPQYSWRINGIPQQH----------TQVLFIAKITPNNNGTYACFVSNLATGRNNS 667 + W + + T L + + + G Y C ++ G+ + Sbjct: 150 RDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYN 209 Query: 668 IVKSI 672 I +SI Sbjct: 210 ITRSI 214 Score = 48.0 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 29/150 (19%), Positives = 48/150 (32%), Gaps = 26/150 (17%) Query: 107 LLIQNIIQNDTGFYTLHVIK---SDLVNEEATGQFRVYPELP---KPSISSNNSKPVEDK 160 LL+ ++ D G+Y + N + + R+ + IS + Sbjct: 182 LLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLG 241 Query: 161 DAVAFTCEP---ETQDATY-LWWVNNQSLPVS----------PRLQLSNGNRT-----LT 201 + C+ T LWW N + S PR + S N L Sbjct: 242 SRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSENNENYIEVPLI 301 Query: 202 LFNVTRNDTAS-YKCETQNPVSARRSDSVI 230 VTR D +KC N +S + + + Sbjct: 302 FDPVTREDLHMDFKCVVHNTLSFQTLRTTV 331 >4DEP-B nrPDB Length = 321 Score = 77.3 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 49/274 (17%), Positives = 85/274 (31%), Gaps = 40/274 (14%) Query: 169 PETQDATYLWWVNNQSLPVSPRL--QLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRS 226 P T W+ ++ PVS ++ L D+ Y C +N R Sbjct: 33 PNEHKGTITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRI 92 Query: 227 DSVILNVLYGPDAPT--ISPLNTSYRSGENLNLSCH------AASNPPAQYSWFVNGT-- 276 V P+ + + L C +N + W+ + Sbjct: 93 KISAKFVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPL 152 Query: 277 ------FQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNR-TTVTTITVYAE---PPKPF 326 F L + N+ + G+YTC A + G T + E P +P Sbjct: 153 LLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPV 212 Query: 327 ITSN--NSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSND---------- 374 I S + V+ + L C Q + +W N S+ L D Sbjct: 213 IVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANK 272 Query: 375 --NRTLTLLSV----TRNDVGPYECGIQNKLSVD 402 + +T+L++ +R P+ C +N +D Sbjct: 273 RRSTLITVLNISEIESRFYKHPFTCFAKNTHGID 306 Score = 64.2 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 44/262 (16%), Positives = 81/262 (30%), Gaps = 48/262 (18%) Query: 446 QYSWLID-----------GNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTI 494 +W D I QH ++L+ ++SG Y C NS+ Sbjct: 39 TITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKF 98 Query: 495 TVSAELPKPSISSNNSKPVEDKDAVA----FTC-------EPEAQNTTYLWWVNGQSLPV 543 +P++ N + K VA C + W+ + + L + Sbjct: 99 VE----NEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLL 154 Query: 544 SPRLQLSNGNRTLTLFNVTRNDARAYVCGIQ-NSVSANRSDPVTLDVLY-------GPDT 595 + S L + NV Y C + P+T + + Sbjct: 155 D-NIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGK--QYPITRVIEFITLEENKPTRP 211 Query: 596 PIISPPDSS--YLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTY 653 I+SP + + G+ + L C+ S W+ NG + + Y Sbjct: 212 VIVSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDED-----DPVLGED--YY 264 Query: 654 ACFVSNLATGRNNSIVKSITVS 675 V N A R ++++ + +S Sbjct: 265 --SVENPANKRRSTLITVLNIS 284 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 40/271 (14%), Positives = 75/271 (27%), Gaps = 59/271 (21%) Query: 268 QYSWFVN-----------GTFQQSTQELFIPNITVNNSGSYTCQAHNS----DTGLNRTT 312 +W+ + Q ++L+ V +SG Y C NS ++ Sbjct: 39 TITWYKDDSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAKF 98 Query: 313 VTTITVYAEPPKPFITSNNSNPVEDEDAVALTC------EPEIQNTTYLWWVNNQSLPVS 366 V + + L C + E L W + + Sbjct: 99 VENEPNLCYNAQAIFKQKLPVAGDGG----LVCPYMEFFKNENNELPKLQWYKDCKPLLL 154 Query: 367 PRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLY------GPDDPTI 420 + S L +++V G Y C + + P+ + + P P I Sbjct: 155 DNIHFSGVKDRLIVMNVAEKHRGNYTC-HASYTYLGKQYPITRVIEFITLEENKPTRPVI 213 Query: 421 SPSYTYYRP---GVNLSLSCHAASNPPAQYSWLIDGNI--------------------QQ 457 G + L C+ W +G++ ++ Sbjct: 214 VSPANETMEVDLGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKR 273 Query: 458 HTQELFISNITEKNSGLY----TCQANNSAS 484 + + + NI+E S Y TC A N+ Sbjct: 274 RSTLITVLNISEIESRFYKHPFTCFAKNTHG 304 Score = 36.5 bits (82), Expect = 0.037, Method: Composition-based stats. Identities = 26/153 (16%), Positives = 52/153 (33%), Gaps = 26/153 (16%) Query: 106 SLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELP------KPSISS-NNSKPVE 158 L++ N+ + G YT H + L + + + L +S N + V+ Sbjct: 165 RLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPANETMEVD 224 Query: 159 DKDAVAFTCEPETQDATYLWWVNN-----QSLPVSPRLQLSNGNRT-------LTLFNVT 206 + C Q + +W N + PV S N +T+ N++ Sbjct: 225 LGSQIQLICNVTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANKRRSTLITVLNIS 284 Query: 207 RNDTASY----KCETQNPVSARRSDSVILNVLY 235 ++ Y C +N D+ + ++Y Sbjct: 285 EIESRFYKHPFTCFAKN---THGIDAAYIQLIY 314 >3S35-X nrPDB Length = 122 Score = 75.4 bits (183), Expect = 9e-14, Method: Composition-based stats. Identities = 29/121 (23%), Positives = 40/121 (33%), Gaps = 25/121 (20%) Query: 413 YGPDDPTISPSY-TYYRPGVNLSLSCHAAS--NPPAQYSWLIDGNIQQHT---------- 459 Y D +SPS+ G L L+C A + N ++W + QH Sbjct: 5 YRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQ 64 Query: 460 ---------QELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNS 510 L I +T + GLYTC A+ SG T E P + S Sbjct: 65 SGSEMKKFLSTLTIDGVTRSDQGLYTCAAS---SGLMTKKNSTFVRVHEKPFVAFGSGME 121 Query: 511 K 511 Sbjct: 122 S 122 Score = 63.8 bits (153), Expect = 3e-10, Method: Composition-based stats. Identities = 23/118 (19%), Positives = 50/118 (42%), Gaps = 12/118 (10%) Query: 40 STPFNVAEGKEVLLLVHNLPQHLFG--YSWYKGERVDGNRQIIGYVIGTQQATPGPAYSG 97 S ++ G++++L + G ++W +++++ + TQ SG Sbjct: 15 SHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQ--------SG 66 Query: 98 REIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSK 155 E+ ++L I + ++D G YT S L+ ++ + RV+ E P + S Sbjct: 67 SEMKKFLSTLTIDGVTRSDQGLYTCAAS-SGLMTKKNSTFVRVH-EKPFVAFGSGMES 122 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 16/106 (15%), Positives = 35/106 (33%), Gaps = 14/106 (13%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQ---------NTTYLWWVNNQSLPVSPRLQLSNDN 375 ++ ++ + + + L C + + + + + Q ++ Sbjct: 10 VVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEM 69 Query: 376 ----RTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDD 417 TLT+ VTR+D G Y C + L + + V P Sbjct: 70 KKFLSTLTIDGVTRSDQGLYTCAASSGLMTK-KNSTFVRVHEKPFV 114 Score = 35.3 bits (79), Expect = 0.099, Method: Composition-based stats. Identities = 13/56 (23%), Positives = 25/56 (44%), Gaps = 1/56 (1%) Query: 182 NQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGP 237 N+ L ++ TLT+ VTR+D Y C + + +++ + + V P Sbjct: 58 NRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNST-FVRVHEKP 112 Score = 34.9 bits (78), Expect = 0.13, Method: Composition-based stats. Identities = 9/37 (24%), Positives = 15/37 (40%) Query: 638 QVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITV 674 L I +T ++ G Y C S+ + NS + Sbjct: 74 STLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHE 110 >1Z7Z-I nrPDB Length = 450 Score = 67.7 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 76/470 (16%), Positives = 145/470 (30%), Gaps = 63/470 (13%) Query: 241 TISPLNTSYRSGENLNLSCHA---------ASNPPAQYSWFVNGTFQQSTQELFIPNITV 291 ++SP G ++ ++C P + ++++ + Sbjct: 3 SVSPSKVILPRGGSVLVTCSTSCDQPMLLGIETPLP----KKELLLPGNNRKVYELSNVQ 58 Query: 292 NNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITS-NNSNPVEDEDAVALTCEPEIQ 350 +S C N G + +TVY P + + + PV + L C+ E Sbjct: 59 EDSQP-MC-YSNCPDGQSTAKTF-LTVYWTPERVELAPLPSWQPV--GKNLTLRCQVEGG 113 Query: 351 NT----TYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVG-PYECGIQNKLS----- 400 T + + L P + + T L V R+ G + C + L Sbjct: 114 APRANLTVVLLRGEKELKREPAVGEPAEVTTTVL--VRRDHHGANFSCRTELDLRPQGLE 171 Query: 401 --VDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAAS-NPPAQYSWLIDGNIQQ 457 + S P L P P S ++ C P ++ + Q+ Sbjct: 172 LFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQR 231 Query: 458 HTQELFISN----------ITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISS 507 + N +T ++ G S+ T++T+T+ + I + Sbjct: 232 LNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILT 291 Query: 508 NNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDAR 567 V + V CE + + P+ PR Q L L ++ R Sbjct: 292 KPE--VSEGTEVTVKCEA--HPRAKVTLNGVPAQPLGPRAQ-------LLLKATPEDNGR 340 Query: 568 AYVCGIQNSVSAN---RSDPVTLDVLYGPDTPIISPPDSSYLSGANL-NLSCHSASNPSP 623 ++ C V+ ++ L VLYGP P + + C + NP P Sbjct: 341 SFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLP 400 Query: 624 QYSWRING-IPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSI 672 + +G P + + +T + GTY C + + ++ Sbjct: 401 ELKCLKDGTFPLPIGESVT---VTRDLEGTYLCRARSTQGEVTREVTVNV 447 Score = 54.6 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 70/463 (15%), Positives = 128/463 (27%), Gaps = 54/463 (11%) Query: 159 DKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ 218 +V TC L LP L N + L NV + C + Sbjct: 13 RGGSVLVTCSTSCDQPMLLGI--ETPLPKKELLLPGNNRKVYELSNVQEDSQPM--CYSN 68 Query: 219 NPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQ 278 P + + L V + P+ ++PL + G+NL L C P + Sbjct: 69 CPDGQSTAKT-FLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRAN--LTVVLLR 125 Query: 279 QSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTI---------------------T 317 + P + + T G N + T + Sbjct: 126 GEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTF 185 Query: 318 VYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTY--LWWVNNQSLPVSPRLQLSNDN 375 V P ++ V C + + ++P + ND+ Sbjct: 186 VLPATPPQLVSPRVLEVDTQGTVV---CSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDS 242 Query: 376 RTLTLL-SVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLS 434 + SVT D G L + + +Y P + + G ++ Sbjct: 243 FSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVT 302 Query: 435 LSCHAASNPPAQYSWLIDGNIQQ---HTQELFISNITEKNSGLYTCQANNSASGHSRTTV 491 + C A +P A+ + ++G Q +L + E N ++C A +G Sbjct: 303 VKCEA--HPRAKVT--LNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKN 358 Query: 492 KTITVSAELPKPSISS--NNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQL 549 +T + + + C+ L Sbjct: 359 QTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLP------ELKCLKDGTFPL 412 Query: 550 SNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYG 592 G VTR+ Y+C +++ + VT++VL Sbjct: 413 PIGESV----TVTRDLEGTYLCRARSTQG-EVTREVTVNVLSP 450 Score = 34.1 bits (76), Expect = 0.19, Method: Composition-based stats. Identities = 21/120 (17%), Positives = 39/120 (32%), Gaps = 5/120 (4%) Query: 503 PSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVT 562 + S + + +V TC L ++ L L NR + + Sbjct: 1 QTSVSPSKVILPRGGSVLVTCSTSCDQPMLL---GIETPLPKKELLLPGNNRKVYELSNV 57 Query: 563 RNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPS 622 + D++ +C + + L V + P+ ++P S G NL L C Sbjct: 58 QEDSQP-MCYSNCPDGQSTAKTF-LTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAP 115 >2EO9-A nrPDB Length = 118 Score = 67.7 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 22/99 (22%), Positives = 30/99 (30%), Gaps = 9/99 (9%) Query: 592 GPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRING---------IPQQHTQVLFI 642 GP P + + LSC + +P P WR +G I Q VL I Sbjct: 7 GPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQI 66 Query: 643 AKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSP 681 + G Y C S + S + P Sbjct: 67 RYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 105 Score = 55.7 bits (132), Expect = 7e-08, Method: Composition-based stats. Identities = 25/102 (24%), Positives = 34/102 (33%), Gaps = 12/102 (11%) Query: 236 GPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTF---------QQSTQELFI 286 GP P+N + LSC A +P W +G Q L I Sbjct: 7 GPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQI 66 Query: 287 PNITVNNSGSYTCQAHN---SDTGLNRTTVTTITVYAEPPKP 325 + ++G YTC A T V V +PP+P Sbjct: 67 RYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRP 108 Score = 54.6 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 23/102 (22%), Positives = 36/102 (35%), Gaps = 14/102 (13%) Query: 417 DPTISPSYTYYRPGVNL--SLSCHAASNPPAQYSWLIDGNI---------QQHTQELFIS 465 P I V+ LSC A +P W DG + Q L I Sbjct: 8 PPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 67 Query: 466 NITEKNSGLYTCQANNSASGHSRTT---VKTITVSAELPKPS 504 ++G YTC A+ + + + V+ V + P+P+ Sbjct: 68 YAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPT 109 Score = 51.9 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 16/110 (14%), Positives = 25/110 (22%), Gaps = 1/110 (0%) Query: 501 PKPSISSNNSKPVEDKDAVAFTCEPEAQN-TTYLWWVNGQSLPVSPRLQLSNGNRTLTLF 559 P ++ V +C T LW +G + N L + Sbjct: 8 PPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 67 Query: 560 NVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGA 609 D Y C +G P D + + A Sbjct: 68 YAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSA 117 Score = 47.6 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 12/81 (14%), Positives = 21/81 (25%), Gaps = 1/81 (1%) Query: 144 LPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSN-GNRTLTL 202 P ++ V +C + W + L + ++ N L + Sbjct: 7 GPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQI 66 Query: 203 FNVTRNDTASYKCETQNPVSA 223 DT Y C P Sbjct: 67 RYAKLGDTGRYTCIASTPSGE 87 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 16/108 (14%), Positives = 28/108 (25%), Gaps = 1/108 (0%) Query: 323 PKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSN-DNRTLTLL 381 P + V + L+C + W + L + ++ +N L + Sbjct: 8 PPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 67 Query: 382 SVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRP 429 D G Y C I +G P+ P Sbjct: 68 YAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIP 115 >6FEY-A nrPDB Length = 242 Score = 65.7 bits (158), Expect = 6e-11, Method: Composition-based stats. Identities = 38/211 (18%), Positives = 77/211 (36%), Gaps = 22/211 (10%) Query: 41 TPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREI 100 T A+G + ++ + + W G R + + Q A P I Sbjct: 41 TKLQQADGATIEIVCEMMGSQVPSIQWVVG---HLPRSELDDLDSNQVAEEAP----SAI 93 Query: 101 IYPNASLLIQNIIQNDTGFYTLH-------VIKSDLVNEEATGQF---RVYPELPKPSIS 150 + +S +I +++ ++ YT + S +V+ + + + YP KP I Sbjct: 94 VRVRSSHIIDHVL-SEARTYTCVGRTGSKTIYASTVVHPPRSSRLTPEKTYPGAQKPRII 152 Query: 151 SNNSKPVE-DKDAVAFTCEPETQDATYLWWVNNQ--SLPVSPRLQLSNGNRTLTLFNVTR 207 ++ + C + + W+NN+ + R ++ N L + + Sbjct: 153 YTEKTHLDLMGSNIQLPCRVHARPRAEITWLNNENKEIVQGHRHRV-LANGDLLISEIKW 211 Query: 208 NDTASYKCETQNPVSARRSDSVILNVLYGPD 238 D +YKC +N V +D+ + VL D Sbjct: 212 EDMGNYKCIARNVVGKDTADTFVYPVLNEED 242 Score = 64.2 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 28/203 (13%), Positives = 53/203 (26%), Gaps = 30/203 (14%) Query: 418 PTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQEL-----------FISN 466 P+ G + + C + W++ + +L I Sbjct: 36 TKTPPTKLQQADGATIEIVCEMMGSQVPSIQWVVGHLPRSELDDLDSNQVAEEAPSAIVR 95 Query: 467 ITEKN--------SGLYTCQANNSASGHSRTTV----KTITVSAELPKPSISSNN----- 509 + + + YTC + +TV ++ ++ E P Sbjct: 96 VRSSHIIDHVLSEARTYTCVGRTGSKTIYASTVVHPPRSSRLTPEKTYPGAQKPRIIYTE 155 Query: 510 -SKPVEDKDAVAFTCEPEAQNTT-YLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDAR 567 + + C A+ W N V N L + + D Sbjct: 156 KTHLDLMGSNIQLPCRVHARPRAEITWLNNENKEIVQGHRHRVLANGDLLISEIKWEDMG 215 Query: 568 AYVCGIQNSVSANRSDPVTLDVL 590 Y C +N V + +D VL Sbjct: 216 NYKCIARNVVGKDTADTFVYPVL 238 Score = 61.1 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 38/233 (16%), Positives = 65/233 (27%), Gaps = 37/233 (15%) Query: 291 VNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQ 350 V++S NS A+ K T D + + CE Sbjct: 6 VDDSND----VDNSIEAEEEKPR-NRAFEADWLKFTKTPPTKLQQADGATIEIVCEMMGS 60 Query: 351 NTTYLWW------VNNQSLPVSPRLQLSNDNRTLT-----LLSVTRNDVGPYECGIQN-- 397 + W + S ++ + + ++ ++ Y C + Sbjct: 61 QVPSIQWVVGHLPRSELDDLDSNQVAEEAPSAIVRVRSSHIIDHVLSEARTYTCVGRTGS 120 Query: 398 ---KLSVDHSDPVILNVLYGPDDPTISPSYTYYRP-------GVNLSLSCHAASNPPAQY 447 S P + P Y G N+ L C + P A+ Sbjct: 121 KTIYASTVVHPPRSSRLTPEKTYPGAQKPRIIYTEKTHLDLMGSNIQLPCRVHARPRAEI 180 Query: 448 SWLIDGNI-----QQH----TQELFISNITEKNSGLYTCQANNSASGHSRTTV 491 +WL + N +H +L IS I ++ G Y C A N + T Sbjct: 181 TWLNNENKEIVQGHRHRVLANGDLLISEIKWEDMGNYKCIARNVVGKDTADTF 233 Score = 60.7 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 32/208 (15%), Positives = 60/208 (28%), Gaps = 40/208 (19%) Query: 244 PLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNIT------------- 290 P G + + C + W V + +L + Sbjct: 40 PTKLQQADGATIEIVCEMMGSQVPSIQWVVGHLPRSELDDLDSNQVAEEAPSAIVRVRSS 99 Query: 291 ------VNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVED------- 337 ++ + +YTC + +TV P +T + P Sbjct: 100 HIIDHVLSEARTYTCVGRTGSKTIYASTVVH-----PPRSSRLTPEKTYPGAQKPRIIYT 154 Query: 338 --------EDAVALTCEPEIQNTTYLWWVNNQSL-PVSPRLQLSNDNRTLTLLSVTRNDV 388 + L C + + W+NN++ V N L + + D+ Sbjct: 155 EKTHLDLMGSNIQLPCRVHARPRAEITWLNNENKEIVQGHRHRVLANGDLLISEIKWEDM 214 Query: 389 GPYECGIQNKLSVDHSDPVILNVLYGPD 416 G Y+C +N + D +D + VL D Sbjct: 215 GNYKCIARNVVGKDTADTFVYPVLNEED 242 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 37/190 (19%), Positives = 59/190 (31%), Gaps = 32/190 (16%) Query: 514 EDKDAVAFTCEPEAQNTTYLWWVNGQSL------PVSPRLQLSNGNRTLTLFNVTRND-- 565 D + CE + WV G S ++ + + + + D Sbjct: 46 ADGATIEIVCEMMGSQVPSIQWVVGHLPRSELDDLDSNQVAEEAPSAIVRVRSSHIIDHV 105 Query: 566 ---ARAYVCG---------IQNSVSANRSDPVTLDVLYG-PDTPIISPPDSSYL--SGAN 610 AR Y C V RS +T + Y P I + ++L G+N Sbjct: 106 LSEARTYTCVGRTGSKTIYASTVVHPPRSSRLTPEKTYPGAQKPRIIYTEKTHLDLMGSN 165 Query: 611 LNLSCHSASNPSPQYSWRIN---GIPQQH------TQVLFIAKITPNNNGTYACFVSNLA 661 + L C + P + +W N I Q H L I++I + G Y C N+ Sbjct: 166 IQLPCRVHARPRAEITWLNNENKEIVQGHRHRVLANGDLLISEIKWEDMGNYKCIARNVV 225 Query: 662 TGRNNSIVKS 671 Sbjct: 226 GKDTADTFVY 235 Score = 32.2 bits (71), Expect = 0.76, Method: Composition-based stats. Identities = 17/107 (15%), Positives = 28/107 (26%), Gaps = 19/107 (17%) Query: 600 PPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKI-------------- 645 P GA + + C + P W + +P+ L ++ Sbjct: 40 PTKLQQADGATIEIVCEMMGSQVPSIQWVVGHLPRSELDDLDSNQVAEEAPSAIVRVRSS 99 Query: 646 -----TPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSAGA 687 + TY C + S V S+ T GA Sbjct: 100 HIIDHVLSEARTYTCVGRTGSKTIYASTVVHPPRSSRLTPEKTYPGA 146 >6A77-A nrPDB Length = 91 Score = 65.0 bits (156), Expect = 1e-10, Method: Composition-based stats. Identities = 19/83 (22%), Positives = 27/83 (32%), Gaps = 9/83 (10%) Query: 599 SPPDSSYLSGANLNLSCHSASNPSPQYSWRING---------IPQQHTQVLFIAKITPNN 649 P + + LSC + +P P WR +G I Q VL I + Sbjct: 8 GPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGD 67 Query: 650 NGTYACFVSNLATGRNNSIVKSI 672 G Y C S + S + Sbjct: 68 TGRYTCIASTPSGEATWSAYIEV 90 Score = 56.5 bits (134), Expect = 4e-08, Method: Composition-based stats. Identities = 17/72 (23%), Positives = 24/72 (33%), Gaps = 9/72 (12%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTF---------QQSTQELFIPNITV 291 P+N + LSC A +P W +G Q L I + Sbjct: 6 RQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKL 65 Query: 292 NNSGSYTCQAHN 303 ++G YTC A Sbjct: 66 GDTGRYTCIAST 77 Score = 51.9 bits (122), Expect = 9e-07, Method: Composition-based stats. Identities = 11/80 (13%), Positives = 17/80 (21%), Gaps = 1/80 (1%) Query: 502 KPSISSNNSKPVEDKDAVAFTCEPEAQN-TTYLWWVNGQSLPVSPRLQLSNGNRTLTLFN 560 ++ V +C T LW +G + N L + Sbjct: 3 PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRY 62 Query: 561 VTRNDARAYVCGIQNSVSAN 580 D Y C Sbjct: 63 AKLGDTGRYTCIASTPSGEA 82 Score = 51.5 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 19/89 (21%), Positives = 29/89 (32%), Gaps = 11/89 (12%) Query: 418 PTISPSYTYYRPGVNL--SLSCHAASNPPAQYSWLIDGNI---------QQHTQELFISN 466 P I V+ LSC A +P W DG + Q L I Sbjct: 3 PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRY 62 Query: 467 ITEKNSGLYTCQANNSASGHSRTTVKTIT 495 ++G YTC A+ + + + + Sbjct: 63 AKLGDTGRYTCIASTPSGEATWSAYIEVQ 91 Score = 48.0 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 11/79 (13%), Positives = 20/79 (25%), Gaps = 1/79 (1%) Query: 146 KPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSN-GNRTLTLFN 204 ++ V +C + W + L + ++ N L + Sbjct: 3 PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRY 62 Query: 205 VTRNDTASYKCETQNPVSA 223 DT Y C P Sbjct: 63 AKLGDTGRYTCIASTPSGE 81 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 11/73 (15%), Positives = 21/73 (28%), Gaps = 1/73 (1%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSN-DNRTLTLLSV 383 + V + L+C + W + L + ++ +N L + Sbjct: 4 VIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYA 63 Query: 384 TRNDVGPYECGIQ 396 D G Y C Sbjct: 64 KLGDTGRYTCIAS 76 >5VI4-C nrPDB Length = 339 Score = 64.2 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 45/285 (15%), Positives = 83/285 (29%), Gaps = 57/285 (20%) Query: 169 PETQDATYLWWVNNQSLPVS-------PRLQLSNGNRTLTLFNVTRNDTASYKCETQNPV 221 + T +W+ Q + P ++S L DT Y C +N Sbjct: 44 AHSSGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLQDTGQYTCMLRN-- 101 Query: 222 SARRSDSVILNVLYGPDAPTIS-----PLNTSYRSGENLNLSCH-AASNPP----AQYSW 271 V + + P++ Y ++C P +W Sbjct: 102 -TTYCSKVAFPLEVVQKDSCFNSAMRFPVHKMYIEHGIHKITCPNVDGYFPSSVKPSVTW 160 Query: 272 FVNGT---------FQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYA-- 320 + T + FIP V+N+G YTC + G T+TV Sbjct: 161 YKGCTEIVDFHNVLPEGMQLSFFIP--LVSNNGQYTCVVTYPENGRLFHLTRTVTVKVVG 218 Query: 321 ----EPPKPFITSNNSNPV--EDEDAVALTCEPE----IQNTTYLWWVNNQSLPVSPRLQ 370 P + N+ E + + + C+ + + +WW + P + Sbjct: 219 SPKDALPPQIYSPNDRVVYEKEPGEELVIPCKVYFSFIMDSHNEVWWTIDGKKPDDVTVD 278 Query: 371 LSND-------------NRTLTLLSVTRND-VGPYECGIQNKLSV 401 ++ + + L++ VT D Y C +N Sbjct: 279 ITINESVSYSSTEDETRTQILSIKKVTPEDLRRNYVCHARNTKGE 323 Score = 51.5 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 42/262 (16%), Positives = 74/262 (28%), Gaps = 44/262 (16%) Query: 444 PAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKP 503 L + I + L+ +++G YTC N+ + Sbjct: 64 EPINFRLPENRISKEKDVLWFRPTLLQDTGQYTCMLRNTTYCSKVAFPLEVVQKDSCFNS 123 Query: 504 SISSNNSKPVEDKDAVAFTCE------PEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLT 557 ++ K + TC P + + W+ + + + Sbjct: 124 AMRFPVHKMYIEHGIHKITCPNVDGYFPSSVKPSVTWYKGCTEIVDFHNVLPEGMQLSFF 183 Query: 558 LFNVTRNDARAYVCGI---QNSVSANRSDPVTLDVLYGP----DTPIISPPDSSYL---S 607 + V+ N Y C + +N + + VT+ V+ P I SP D Sbjct: 184 IPLVSNN--GQYTCVVTYPENGRLFHLTRTVTVKVVGSPKDALPPQIYSPNDRVVYEKEP 241 Query: 608 GANLNLSCHSASNPSP----QYSWRINGIPQQH---------------------TQVLFI 642 G L + C + + W I+G TQ+L I Sbjct: 242 GEELVIPCKVYFSFIMDSHNEVWWTIDGKKPDDVTVDITINESVSYSSTEDETRTQILSI 301 Query: 643 AKITPNN-NGTYACFVSNLATG 663 K+TP + Y C N Sbjct: 302 KKVTPEDLRRNYVCHARNTKGE 323 Score = 34.9 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 29/162 (17%), Positives = 54/162 (33%), Gaps = 23/162 (14%) Query: 534 WWVNGQSLPVS-----PRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLD 588 W + L P ++S L D Y C ++N+ ++ Sbjct: 55 WTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLQDTGQYTCMLRNTTYCSKVAFPLEV 114 Query: 589 VLYGP--DTPIISPPDSSYLSGANLNLSC-HSASNPS----PQYSW---------RINGI 632 V ++ + P Y+ ++C + P +W N + Sbjct: 115 VQKDSCFNSAMRFPVHKMYIEHGIHKITCPNVDGYFPSSVKPSVTWYKGCTEIVDFHNVL 174 Query: 633 PQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITV 674 P+ FI + +NNG Y C V+ GR + +++TV Sbjct: 175 PEGMQLSFFIPLV--SNNGQYTCVVTYPENGRLFHLTRTVTV 214 >3O4O-B nrPDB Length = 339 Score = 62.6 bits (150), Expect = 6e-10, Method: Composition-based stats. Identities = 47/280 (16%), Positives = 86/280 (30%), Gaps = 47/280 (16%) Query: 169 PETQDATYLWWVNNQSLPVS-------PRLQLSNGNRTLTLFNVTRNDTASYKCETQNPV 221 + T +W+ Q + P ++S L NDT +Y C +N Sbjct: 44 AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 103 Query: 222 --SARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCH-AASNPP----AQYSWFVN 274 S ++ ++P P++ Y ++C P +W++ Sbjct: 104 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG 163 Query: 275 G-------TFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYA--EPPK- 324 L ++N+G+YTC + G T+TV P Sbjct: 164 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA 223 Query: 325 --PFITSNNSNPVEDEDAVALTCEPEIQNTTYL-------WWVNNQSLPVS--------- 366 P I S N + V +++ P ++L WW + P Sbjct: 224 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE 283 Query: 367 ----PRLQLSNDNRTLTLLSVTRNDVGP-YECGIQNKLSV 401 R + + L++ VT D+ Y C ++ Sbjct: 284 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGE 323 Score = 51.9 bits (122), Expect = 9e-07, Method: Composition-based stats. Identities = 39/262 (14%), Positives = 77/262 (29%), Gaps = 44/262 (16%) Query: 444 PAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKP 503 L + I + L+ ++G YTC N+ + Sbjct: 64 EPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNS 123 Query: 504 SISSNNSKPVEDKDAVAFTCE------PEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLT 557 + K + TC P + T W++ + + N + Sbjct: 124 PMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFL 183 Query: 558 LFNVTRNDARAYVCGI---QNSVSANRSDPVTLDVLYGPD---TPIISPPDSSYLS---- 607 + ++ N Y C + +N + + + +T+ V+ P P+I P+ + Sbjct: 184 IALISNN--GNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEP 241 Query: 608 GANLNLSCHSA----SNPSPQYSWRINGIPQQH---------------------TQVLFI 642 G L + C + + W I+G TQ+L I Sbjct: 242 GEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSI 301 Query: 643 AKITPNN-NGTYACFVSNLATG 663 K+T + +Y C + Sbjct: 302 KKVTSEDLKRSYVCHARSAKGE 323 Score = 37.6 bits (85), Expect = 0.021, Method: Composition-based stats. Identities = 33/162 (20%), Positives = 56/162 (34%), Gaps = 23/162 (14%) Query: 534 WWVNGQSLPVS-----PRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLD 588 W + L P ++S L ND Y C ++N+ ++ Sbjct: 55 WTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEV 114 Query: 589 VLYGP--DTPIISPPDSSYLSGANLNLSC-HSASNPS----PQYSW---------RINGI 632 V ++P+ P Y+ ++C + P +W N I Sbjct: 115 VQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVI 174 Query: 633 PQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITV 674 P+ IA I +NNG Y C V+ GR + +++TV Sbjct: 175 PEGMNLSFLIALI--SNNGNYTCVVTYPENGRTFHLTRTLTV 214 >5FTT-A nrPDB Length = 285 Score = 62.3 bits (149), Expect = 7e-10, Method: Composition-based stats. Identities = 42/265 (15%), Positives = 73/265 (27%), Gaps = 32/265 (12%) Query: 142 PELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYL-------WWVNNQSLPVSPRLQLS 194 P I + + +A C+ + A + W N+ + + S Sbjct: 17 PGTLPHFIEEPEDAYIIKSNPIALRCKA--RPAMQIFFKCNGEWVHQNEHVSEESLDESS 74 Query: 195 NGNRTLTLFNVTRNDTASY--------KCETQNPVSARRSDSVILNVLYGPDAPTISPLN 246 NVTR + +C + + +S + + Y P Sbjct: 75 GLKVREVFINVTRQQVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQG 134 Query: 247 TSYRSGENLNLSC-HAASNPPAQYSWFVNGTFQQSTQE----------LFIPNITVNNSG 295 + L C P A+ W N S Q+ L I +++SG Sbjct: 135 REVPIEGMIVLHCRPPEGVPAAEVEWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSG 194 Query: 296 SYTCQAHNSDTGLNRTTVTTITVYAE---PPKPFITSNNSNPVEDEDAVALTCEPEIQNT 352 +YTC A N R+ T+ VY ++ N + TC Sbjct: 195 NYTCMAAN-IVAKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQKRSRTCTNPAPLN 253 Query: 353 TYLWWVNNQSLPVSPRLQLSNDNRT 377 + ++ D T Sbjct: 254 GGAFCEGMSVQKITCTALCPVDGGT 278 Score = 60.0 bits (143), Expect = 4e-09, Method: Composition-based stats. Identities = 36/203 (17%), Positives = 61/203 (30%), Gaps = 35/203 (17%) Query: 326 FITSNNSNPVEDEDAVALTCEP---------EIQNTTYLW-WVNNQSLPVSPRLQLSNDN 375 FI + + +AL C+ + V+ +SL S L++ Sbjct: 23 FIEEPEDAYIIKSNPIALRCKARPAMQIFFKCNGEWVHQNEHVSEESLDESSGLKVRE-- 80 Query: 376 RTLTLLSVTRNDVGPY--------ECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYY 427 ++VTR V + +C + L S + + Y + P Sbjct: 81 ---VFINVTRQQVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREV 137 Query: 428 RPGVNLSLSCHA-ASNPPAQYSWLIDGNIQ----------QHTQELFISNITEKNSGLYT 476 + L C P A+ WL + + L I +SG YT Sbjct: 138 PIEGMIVLHCRPPEGVPAAEVEWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYT 197 Query: 477 CQANNSASGHSRTTVKTITVSAE 499 C A N + + T+ V Sbjct: 198 CMAANIVAKRRSLS-ATVVVYVN 219 Score = 52.6 bits (124), Expect = 6e-07, Method: Composition-based stats. Identities = 20/117 (17%), Positives = 36/117 (30%), Gaps = 6/117 (5%) Query: 121 TLHVIKSDLVNEEATGQFRV-YPELPKPSISSNNSKPVEDKDAVAFTCEPE-TQDATYL- 177 ++ R+ Y P+E + C P A + Sbjct: 102 QCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIE--GMIVLHCRPPEGVPAAEVE 159 Query: 178 WWVNNQSLPVSPRLQLSN-GNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNV 233 W N + + + + L + +D+ +Y C N V+ RRS S + V Sbjct: 160 WLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVV 216 Score = 52.2 bits (123), Expect = 8e-07, Method: Composition-based stats. Identities = 33/196 (16%), Positives = 59/196 (30%), Gaps = 22/196 (11%) Query: 418 PTISPSYTYYRPGVNLSLSCHAASNPPAQY----SWLI----------DGNIQQHTQELF 463 P Y ++L C A + W+ D + +E+F Sbjct: 23 FIEEPEDAYIIKSNPIALRCKARPAMQIFFKCNGEWVHQNEHVSEESLDESSGLKVREVF 82 Query: 464 ISNITE--KNS-GL--YTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDA 518 I+ + ++ G Y CQ + + + K A L K + V + Sbjct: 83 INVTRQQVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIEGM 142 Query: 519 VAFTCEPEAQNTT--YLWWVNGQSL-PVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQN 575 + C P W N + + + + L + +D+ Y C N Sbjct: 143 IVLHCRPPEGVPAAEVEWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAAN 202 Query: 576 SVSANRSDPVTLDVLY 591 V+ RS T+ V Sbjct: 203 IVAKRRSLSATVVVYV 218 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 30/206 (14%), Positives = 60/206 (29%), Gaps = 29/206 (14%) Query: 502 KPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLS---NGNRTLTL 558 I + + +A C+ +++ + + L + Sbjct: 21 PHFIEEPEDAYIIKSNPIALRCKAR--PAMQIFFKCNGEWVHQNEHVSEESLDESSGLKV 78 Query: 559 FNVTRNDARAYV------------CGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYL 606 V N R V C + + ++S ++ + Y P Sbjct: 79 REVFINVTRQQVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVP 138 Query: 607 SGANLNLSCHS-ASNPSPQYSWRINGIPQQHTQV----------LFIAKITPNNNGTYAC 655 + L C P+ + W N P Q L I + +++G Y C Sbjct: 139 IEGMIVLHCRPPEGVPAAEVEWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTC 198 Query: 656 FVSN-LATGRNNSIVKSITVSASGTS 680 +N +A R+ S + V+ +S Sbjct: 199 MAANIVAKRRSLSATVVVYVNGGWSS 224 Score = 30.3 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 12/72 (16%), Positives = 22/72 (30%) Query: 104 NASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAV 163 + +L+I+ +D+G YT + VY S + ++ V Sbjct: 180 DHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRGW 239 Query: 164 AFTCEPETQDAT 175 T A Sbjct: 240 QKRSRTCTNPAP 251 >4FRW-A nrPDB Length = 218 Score = 60.3 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 32/163 (19%), Positives = 57/163 (34%), Gaps = 9/163 (5%) Query: 37 TIESTPFNVAEGKEVLLLVHNLPQHLFG-YSWYKGERVDGNRQIIGYVIGTQQATPGPAY 95 T + + + ++ G +W + + +G Q + + PAY Sbjct: 5 TSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEG-AQELALLHSKYGLHVSPAY 63 Query: 96 SGREIIYP------NASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSI 149 GR P + S+L++N +Q D G Y V + +A + RV P PS+ Sbjct: 64 EGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVP-PLPSL 122 Query: 150 SSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQ 192 + + +A +C E A + W S R Sbjct: 123 NPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSF 165 Score = 55.7 bits (132), Expect = 6e-08, Method: Composition-based stats. Identities = 21/93 (22%), Positives = 35/93 (37%), Gaps = 3/93 (3%) Query: 535 WVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPD 594 + P PR L + ++ L N + D Y C + + + + L VL P Sbjct: 63 YEGRVEQPPPPRNPL---DGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPL 119 Query: 595 TPIISPPDSSYLSGANLNLSCHSASNPSPQYSW 627 + P G L SC + +P+P +W Sbjct: 120 PSLNPGPALEEGQGLTLAASCTAEGSPAPSVTW 152 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 29/187 (15%), Positives = 55/187 (29%), Gaps = 15/187 (8%) Query: 215 CETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN 274 C + + V G A ++ L++ Y + PP + Sbjct: 21 CFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPR------ 74 Query: 275 GTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 + + N + G Y C+ G + + V PP P + + Sbjct: 75 ---NPLDGSVLLRNAVQADEGEYECRVSTFPAG-SFQARLRLRVLV-PPLPSLNPGPALE 129 Query: 335 VEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTL---LSVTRNDVG-P 390 +A +C E + W S R + + +T L +R+ G P Sbjct: 130 EGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQP 189 Query: 391 YECGIQN 397 C + + Sbjct: 190 LTCVVSH 196 Score = 47.2 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 22/121 (18%), Positives = 37/121 (30%), Gaps = 12/121 (9%) Query: 375 NRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLS 434 + ++ L + + D G YEC + + + L VL P G+ L+ Sbjct: 78 DGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLA 137 Query: 435 LSCHAASNPPAQYSW------------LIDGNIQQHTQELFISNITEKNSGLYTCQANNS 482 SC A +P +W T E + N TC ++ Sbjct: 138 ASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHP 197 Query: 483 A 483 Sbjct: 198 G 198 Score = 46.5 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 24/100 (24%), Positives = 40/100 (40%), Gaps = 9/100 (9%) Query: 186 PVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPL 245 P PR L + ++ L N + D Y+C + + L VL P P+++P Sbjct: 70 PPPPRNPL---DGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVL-VPPLPSLNPG 125 Query: 246 NTSYRSGENLNL--SCHAASNPPAQYSWFVNGTFQQSTQE 283 G+ L L SC A +P +W + + +T Sbjct: 126 PA-LEEGQGLTLAASCTAEGSPAPSVTW--DTEVKGTTSS 162 Score = 46.1 bits (107), Expect = 6e-05, Method: Composition-based stats. Identities = 19/123 (15%), Positives = 37/123 (30%), Gaps = 8/123 (6%) Query: 459 TQELFISNITEKNSGLYTC-QANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKD 517 + + N + + G Y C + A + V P PS++ + Sbjct: 78 DGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVP---PLPSLNPGPALEEGQGL 134 Query: 518 AVAFTCEPEAQNTTYLWW---VNGQSLPVSPRLQLSNG-NRTLTLFNVTRNDARAYVCGI 573 +A +C E + W V G + S + S L + + C + Sbjct: 135 TLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVV 194 Query: 574 QNS 576 + Sbjct: 195 SHP 197 >4V2A-A nrPDB Length = 303 Score = 60.3 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 33/199 (16%), Positives = 59/199 (29%), Gaps = 32/199 (16%) Query: 240 PTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGS--- 296 + P + + + L C A P Q + NG + + + + +N Sbjct: 46 FLVEPEDVYIVKNKPVLLVCKAV--PATQIFFKCNGEWVRQVDHVIERSTDGSNGLPTME 103 Query: 297 ------------------YTCQ--AHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVE 336 Y CQ A +S Y K F + V Sbjct: 104 VRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLR--KNFEQEPLAKEVS 161 Query: 337 DEDAVALTCEPEIQ-NTTYLWWVNNQSLPV---SPRLQLSNDNRTLTLLSVTRNDVGPYE 392 E + L C P + W+ N+ L P + ++ + +L + D Y Sbjct: 162 LEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITRE-HSLVVRQARLADTANYT 220 Query: 393 CGIQNKLSVDHSDPVILNV 411 C +N ++ S + V Sbjct: 221 CVAKNIVARRRSASAAVIV 239 Score = 59.2 bits (141), Expect = 6e-09, Method: Composition-based stats. Identities = 36/210 (17%), Positives = 63/210 (30%), Gaps = 29/210 (13%) Query: 142 PELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQL------SN 195 P+L + + V C+ AT +++ N + SN Sbjct: 40 PDLLPHFLVEPEDVYIVKNKPVLLVCKAV--PATQIFFKCNGEWVRQVDHVIERSTDGSN 97 Query: 196 GNRTLTLF-NVTRNDTA------SY--KCETQNPVSARRSDSVILNVLYGPDAPTISPLN 246 G T+ + NV+R Y +C + +S + + Y PL Sbjct: 98 GLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLA 157 Query: 247 TSYRSGENLNLSC-HAASNPPAQYSWFVNGTFQQ----------STQELFIPNITVNNSG 295 + + L C PPA+ W N L + + ++ Sbjct: 158 KEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTA 217 Query: 296 SYTCQAHNSDTGLNRTTVTTITVYAEPPKP 325 +YTC A N R+ + VY + Sbjct: 218 NYTCVAKN-IVARRRSASAAVIVYVDGSWS 246 Score = 56.1 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 47/256 (18%), Positives = 76/256 (29%), Gaps = 39/256 (15%) Query: 420 ISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGL----- 474 + P Y + L C A P Q + +G + I T+ ++GL Sbjct: 48 VEPEDVYIVKNKPVLLVCKA--VPATQIFFKCNGEWVRQVD-HVIERSTDGSNGLPTMEV 104 Query: 475 -----------------YTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKD 517 Y CQ +S + + K A L K +K V + Sbjct: 105 RINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQ 164 Query: 518 AVAFTCEPE-AQNTT-YLWWVNGQSLPVS--PRLQLSNGNRTLTLFNVTRNDARAYVCGI 573 + C P W N + S P + ++ + +L + D Y C Sbjct: 165 GIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH-SLVVRQARLADTANYTCVA 223 Query: 574 QNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLN-LSCHSASNPSPQYSWRINGI 632 +N V+ RS + V SP G + S+P+P NG Sbjct: 224 KNIVARRRSASAAVIVYVDGSW---SPWSKWSACGLDCTHWRSRECSDPAP-----RNGG 275 Query: 633 PQQHTQVLFIAKITPN 648 + L T + Sbjct: 276 EECQGTDLDTRNCTSD 291 Score = 54.2 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 33/199 (16%), Positives = 59/199 (29%), Gaps = 29/199 (14%) Query: 323 PKPFITSNNSNPVEDEDAVALTCEPEIQNTTYL------WWVNNQSLPVSPRLQLSNDNR 376 P + + V+ V L C+ T + WV + SN Sbjct: 44 PHFLVEPEDVYIVK-NKPVLLVCKAV--PATQIFFKCNGEWVRQVDHVIERSTDGSNGLP 100 Query: 377 TLTL-LSVTRNDVG------PY--ECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYY 427 T+ + ++V+R V Y +C + S + + Y + P Sbjct: 101 TMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEV 160 Query: 428 RPGVNLSLSCHAA-SNPPAQYSWLIDGNIQQ----------HTQELFISNITEKNSGLYT 476 + L C PPA+ WL + ++ L + ++ YT Sbjct: 161 SLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADTANYT 220 Query: 477 CQANNSASGHSRTTVKTIT 495 C A N + + I Sbjct: 221 CVAKNIVARRRSASAAVIV 239 Score = 53.8 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 37/210 (17%), Positives = 66/210 (31%), Gaps = 14/210 (6%) Query: 29 NPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQ 88 NP +E + + K VLL+ +P + GE V +I Sbjct: 39 NPDLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKC-NGEWVRQVDHVIERSTDGSN 97 Query: 89 ATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRV-YPELPKP 147 P E+ + ++ + + + S + R+ Y Sbjct: 98 GLPT-----MEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFE 152 Query: 148 SISSNNSKPVEDKDAVAFTCEPETQ--DATYLWWVNNQ--SLPVSPRLQLSNGNRTLTLF 203 +E + C P A W N + P + ++ + +L + Sbjct: 153 QEPLAKEVSLEQG--IVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREH-SLVVR 209 Query: 204 NVTRNDTASYKCETQNPVSARRSDSVILNV 233 DTA+Y C +N V+ RRS S + V Sbjct: 210 QARLADTANYTCVAKNIVARRRSASAAVIV 239 >1U2H-A nrPDB Length = 99 Score = 60.3 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 16/87 (18%), Positives = 26/87 (29%), Gaps = 4/87 (4%) Query: 142 PELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWW-VNNQSLPVSPRLQLSNGNR-- 198 + P S + V + V + + + + W N Q + R Sbjct: 2 SKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGL 61 Query: 199 -TLTLFNVTRNDTASYKCETQNPVSAR 224 L + R D Y C+ N AR Sbjct: 62 CRLRILAAERGDAGFYTCKAVNEYGAR 88 Score = 54.6 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 20/93 (21%), Positives = 29/93 (31%), Gaps = 5/93 (5%) Query: 501 PKPSISSNNSKPVEDKDAVAFTCEPEAQNTTY-LWWVNGQSLPVSPR---LQLSNGNRTL 556 P S + V + V + + + W N Q + R + G L Sbjct: 5 PPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCRL 64 Query: 557 TLFNVTRNDARAYVCGIQNSVSANRSDPVTLDV 589 + R DA Y C N A R L+V Sbjct: 65 RILAAERGDAGFYTCKAVNEYGA-RQCEARLEV 96 Score = 52.2 bits (123), Expect = 8e-07, Method: Composition-based stats. Identities = 21/93 (22%), Positives = 28/93 (30%), Gaps = 12/93 (12%) Query: 592 GPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQ------------V 639 P T +S D S G ++ +S P P SW N P + Q Sbjct: 4 APPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCR 63 Query: 640 LFIAKITPNNNGTYACFVSNLATGRNNSIVKSI 672 L I + G Y C N R + Sbjct: 64 LRILAAERGDAGFYTCKAVNEYGARQCEARLEV 96 Score = 49.6 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 18/93 (19%), Positives = 28/93 (30%), Gaps = 12/93 (12%) Query: 414 GPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQ------------E 461 P +S R G ++ +S P SWL + + Q Sbjct: 4 APPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCR 63 Query: 462 LFISNITEKNSGLYTCQANNSASGHSRTTVKTI 494 L I ++G YTC+A N + Sbjct: 64 LRILAAERGDAGFYTCKAVNEYGARQCEARLEV 96 Score = 44.2 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 16/96 (16%), Positives = 34/96 (35%), Gaps = 6/96 (6%) Query: 320 AEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNR--- 376 PP ++ + V + V ++ + + + W+ N+ + + + + Sbjct: 3 KAPPTFKVSLMD-QSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGL 61 Query: 377 -TLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNV 411 L +L+ R D G Y C N+ L V Sbjct: 62 CRLRILAAERGDAGFYTCKAVNEYGAR-QCEARLEV 96 Score = 44.2 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 19/93 (20%), Positives = 31/93 (33%), Gaps = 12/93 (12%) Query: 236 GPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQ------------E 283 P +S ++ S R G+++ +S P SW N + Q Sbjct: 4 APPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPVRPDQRRFAEEAEGGLCR 63 Query: 284 LFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTI 316 L I ++G YTC+A N + Sbjct: 64 LRILAAERGDAGFYTCKAVNEYGARQCEARLEV 96 Score = 36.5 bits (82), Expect = 0.041, Method: Composition-based stats. Identities = 20/110 (18%), Positives = 32/110 (29%), Gaps = 18/110 (16%) Query: 31 PTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQAT 90 P T K+++ + + + V P+ + SW + Q Sbjct: 5 PPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVV--SWLRN---------------RQPVR 47 Query: 91 PGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKS-DLVNEEATGQFR 139 P E L I + D GFYT + EA + R Sbjct: 48 PDQRRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVR 97 >3QS9-E nrPDB Length = 527 Score = 60.0 bits (143), Expect = 4e-09, Method: Composition-based stats. Identities = 64/417 (15%), Positives = 124/417 (29%), Gaps = 71/417 (17%) Query: 245 LNTSYRSGENLNLSC-----HAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSY-- 297 + N+SC H++ N + G + I +T +G Y Sbjct: 66 ITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVV-----SMVILKMTETQAGEYLL 120 Query: 298 --TCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYL 355 +A N + T+ P N AL C E + Sbjct: 121 FIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQD---------ALVCISESVPEPIV 171 Query: 356 WWV-----NNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILN 410 WV SP + + L C +N+L + + ++ Sbjct: 172 EWVLCDSQGESCKEESPAVVKKEEKVLHELFGT------DIRCCARNELGRECTRLFTID 225 Query: 411 VLYGPDDPTISPSYTYYRPGVNLSLSCHAA-SNPPAQYSWLIDGNIQQHTQEL------- 462 + P + + + G L + C A N +W ++ + Sbjct: 226 LN---QTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYST 282 Query: 463 ----------FISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKP 512 F+S++ ++G YTC S+S H + +T+ + + +S+ Sbjct: 283 NRTMIRILFAFVSSVARNDTGYYTC----SSSKHPSQSAL-VTIVEKGFINATNSSEDYE 337 Query: 513 VEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCG 572 ++ + F+ +A W + + L NG N ++ Y+ Sbjct: 338 IDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCN-HKHQPGEYIFH 396 Query: 573 IQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRI 629 +N A + TL++ P + SC S P P ++W+ Sbjct: 397 AEND-DAQFTKMFTLNIRRKP---------QVLAEASASQASCFSDGYPLPSWTWKK 443 Score = 58.8 bits (140), Expect = 7e-09, Method: Composition-based stats. Identities = 45/375 (12%), Positives = 108/375 (28%), Gaps = 64/375 (17%) Query: 106 SLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDK--DAV 163 S++I + + G Y L + EAT ++ + ++ +P K + Sbjct: 104 SMVILKMTETQAGEYLL------FIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQD 157 Query: 164 AFTCEPETQDATYLWWV----NNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQN 219 A C E+ + WV +S + + L +C +N Sbjct: 158 ALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVL-----HELFGTDIRCCARN 212 Query: 220 PVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQ 279 + + +++ P + GE L + C A + T++ Sbjct: 213 ELGRECTRLFTIDLNQTPQTTLPQLF---LKVGEPLWIRCKAV-----HVNHGFGLTWEL 264 Query: 280 STQEL-----------------------FIPNITVNNSGSYTCQAHNSDTGLNRTTVTTI 316 + L F+ ++ N++G YTC + + + + Sbjct: 265 ENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCS-----SSKHPSQSALV 319 Query: 317 TVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNR 376 T+ + S+ ++ + + + W ++ + L N Sbjct: 320 TIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYS 379 Query: 377 TLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLS 436 + ++ G Y +N + + + ++ + S Sbjct: 380 ISKFCN-HKHQPGEYIFHAENDDAQFTK---MFTLNIRRKPQVLAEASASQA-------S 428 Query: 437 CHAASNPPAQYSWLI 451 C + P ++W Sbjct: 429 CFSDGYPLPSWTWKK 443 Score = 36.5 bits (82), Expect = 0.043, Method: Composition-based stats. Identities = 38/242 (15%), Positives = 70/242 (28%), Gaps = 48/242 (19%) Query: 462 LFISNITEKNSGLYT----CQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKD 517 + I +TE +G Y +A N + + T+ + P N V Sbjct: 105 MVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALV---- 160 Query: 518 AVAFTCEPEAQNTTYLWWV----NGQSLPVSPRLQLSNGNRTL-TLFNVTRNDARAYVCG 572 C E+ + WV G+S + + L LF C Sbjct: 161 -----CISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIR------CC 209 Query: 573 IQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQ-YSWRING 631 +N + + T+D+ P T + P G L + C + +W + Sbjct: 210 ARNELGRECTRLFTIDLNQTPQTTL---PQLFLKVGEPLWIRCKAVHVNHGFGLTWELEN 266 Query: 632 IPQQHTQVL-----------------FIAKITPNNNGTYACFVSNLATGRNNSIVKSITV 674 + F++ + N+ G Y C + + S + +I Sbjct: 267 KALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCS---SSKHPSQSALVTIVE 323 Query: 675 SA 676 Sbjct: 324 KG 325 >2RCJ-C nrPDB Length = 523 Score = 59.6 bits (142), Expect = 4e-09, Method: Composition-based stats. Identities = 55/409 (13%), Positives = 111/409 (27%), Gaps = 75/409 (18%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNN---------------QSLPVSPRL 369 +T S V ++C + + W + V R Sbjct: 2 SVLTQPPSASGTPGQRVTISCTGTSSGSITVNWYQQLPGMAPKLLIYRDAMRPSGVPTRF 61 Query: 370 QL--SNDNRTLTLLSVTRNDVGPYEC----GIQNKLSVDHSDPVILNVLYGPDDPT-ISP 422 S + +L + + D Y C N V + + + P Sbjct: 62 SGSKSGTSASLAISGLEAEDESDYYCASWNSSDNSYVFGTGTKVTVLGQPKANPTVTLFP 121 Query: 423 SYTYYRPGVNLSLSCHAAS-NPPA-QYSWLIDGNIQQ-----------------HTQELF 463 + +L C + P A +W DG+ + + L Sbjct: 122 PSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLS 181 Query: 464 ISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTC 523 ++ K+ Y+CQ + S +T T ++ S A C Sbjct: 182 LTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECSASTKGPSVFPLAPSSKSTSGGTAALGC 241 Query: 524 EPEA---QNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRND--------ARAYVCG 572 + Q T W S ++ L++++ + Y+C Sbjct: 242 LVKDYFPQPVTVSW---NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICN 298 Query: 573 IQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSA----SNPSPQYSWR 628 + + S + D + P + + ++C +P +++W Sbjct: 299 VNHKPSNTKVDKRVEPLSLPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPQVKFNWY 358 Query: 629 INGI----------PQQHTQVLFIAKI------TPNNNGTYACFVSNLA 661 ++G+ QQ+ + + + Y C VSN A Sbjct: 359 VDGVQVHNAKTKPREQQYNSTYRVVSVLTVLHQNWLDGKEYKCKVSNKA 407 Score = 58.8 bits (140), Expect = 7e-09, Method: Composition-based stats. Identities = 73/475 (15%), Positives = 139/475 (29%), Gaps = 85/475 (17%) Query: 243 SPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------GTF 277 P + S G+ + +SC S+ +W+ G+ Sbjct: 6 QPPSASGTPGQRVTISCTGTSSGSITVNWYQQLPGMAPKLLIYRDAMRPSGVPTRFSGSK 65 Query: 278 QQSTQELFIPNITVNNSGSYTCQAHNSDTGL----NRTTVTTITVYAEPPKPFITSNNSN 333 ++ L I + + Y C + NS T VT + P + +S Sbjct: 66 SGTSASLAISGLEAEDESDYYCASWNSSDNSYVFGTGTKVTVLGQPKANPTVTLFPPSSE 125 Query: 334 PVEDEDAVALTCEPEIQNTT-YLWWVNNQSLPVS------PRLQLSNDNRTLTLLSVTRN 386 ++ A + + + W + S + P Q +N + LS+T Sbjct: 126 ELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPE 185 Query: 387 D---VGPYECGIQNKLSVDHSDPVILNV---LYGPDDPTISPSYTYYRPGVNLSLSCHAA 440 Y C + ++ S GP ++PS G +L C Sbjct: 186 QWKSHRSYSCQVTHEGSTVEKTVAPTECSASTKGPSVFPLAPSSKSTSGG-TAALGCLVK 244 Query: 441 SN-PPA-QYSWLIDGNIQQHTQELFISNITEKNS-----------------GLYTCQANN 481 P SW + + + + + Y C N+ Sbjct: 245 DYFPQPVTVSW---NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNH 301 Query: 482 SASG------HSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWW 535 S ++ ++ + PK ++ + + V V E + W+ Sbjct: 302 KPSNTKVDKRVEPLSLPSVFLFPPKPKDTLMISRTPEVT---CVVVDVSHEDPQVKFNWY 358 Query: 536 VNGQSL---PVSPRLQLSNGN----RTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLD 588 V+G + PR Q N LT+ + D + Y C + N + Sbjct: 359 VDGVQVHNAKTKPREQQYNSTYRVVSVLTVLHQNWLDGKEYKCKVSNKALPAPIEKTISK 418 Query: 589 VLYGPDTPIIS--PPDSSYLSGANLNLSCHSASNPSPQYS--WRINGIPQQHTQV 639 P P + PP ++ ++L+C + W NG P+ + + Sbjct: 419 AKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKT 473 Score = 56.9 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 76/501 (15%), Positives = 144/501 (28%), Gaps = 81/501 (16%) Query: 160 KDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRLQLSNGNRTLTL 202 V +C + + + W +P S + +L + Sbjct: 15 GQRVTISCTGTSSGSITVNWYQQLPGMAPKLLIYRDAMRPSGVPTRFSGSKSGTSASLAI 74 Query: 203 FNVTRNDTASYKCET--QNPVSARRSDSVILNVLYGPDA-PTI--SPLNTSYRSGENLNL 257 + D + Y C + + S + VL P A PT+ P ++ L Sbjct: 75 SGLEAEDESDYYCASWNSSDNSYVFGTGTKVTVLGQPKANPTVTLFPPSSEELQANKATL 134 Query: 258 SCHAASNPPA--QYSWFVNGTFQQSTQELFIPNITVNNS-----------------GSYT 298 C + P +W +G+ ++ E P+ NN SY+ Sbjct: 135 VCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYS 194 Query: 299 CQAHNSDTGLNRTTVTTI-TVYAEPPKPFITSNNSNPVEDEDAVALTCEPE--IQNTTYL 355 CQ + + + +T T + + P F + +S AL C + + Sbjct: 195 CQVTHEGSTVEKTVAPTECSASTKGPSVFPLAPSSKSTSGG-TAALGCLVKDYFPQPVTV 253 Query: 356 WWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGP------YECGI----QNKLSVDHSD 405 W + + L LS Y C + N + Sbjct: 254 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVE 313 Query: 406 PVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDG----------NI 455 P+ L ++ P V + + +P +++W +DG Sbjct: 314 PLSLPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPQVKFNWYVDGVQVHNAKTKPRE 373 Query: 456 QQHTQE------LFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNN 509 QQ+ L + + + Y C+ +N A + + Sbjct: 374 QQYNSTYRVVSVLTVLHQNWLDGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPP 433 Query: 510 SKPVEDKDAVAFTCEPEAQNT---TYLWWVNGQSL---PVSPRLQLSNGN----RTLTLF 559 S+ K+ V+ TC + W NGQ +P + S+G+ LT+ Sbjct: 434 SREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVD 493 Query: 560 NVTRNDARAYVCGIQNSVSAN 580 + C + + N Sbjct: 494 KSRWQQGNVFSCSVMHEALHN 514 Score = 30.3 bits (66), Expect = 3.1, Method: Composition-based stats. Identities = 16/94 (17%), Positives = 30/94 (31%), Gaps = 25/94 (26%) Query: 594 DTPIISPPDSSYLSGANLNLSCHSASNPSPQYSW-------------------------R 628 ++ + PP +S G + +SC S+ S +W R Sbjct: 1 ESVLTQPPSASGTPGQRVTISCTGTSSGSITVNWYQQLPGMAPKLLIYRDAMRPSGVPTR 60 Query: 629 INGIPQQHTQVLFIAKITPNNNGTYACFVSNLAT 662 +G + L I+ + + Y C N + Sbjct: 61 FSGSKSGTSASLAISGLEAEDESDYYCASWNSSD 94 >1WIO-A nrPDB Length = 363 Score = 59.2 bits (141), Expect = 6e-09, Method: Composition-based stats. Identities = 31/216 (14%), Positives = 73/216 (33%), Gaps = 54/216 (25%) Query: 250 RSGENLNLSCHAASNPPAQYSWF----------------------------VNGTFQQST 281 + G+ + L+C A+ Q+ W + Q Sbjct: 7 KKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGN 66 Query: 282 QELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAV 341 L I N+ + +S +Y C+ ++ + V+ +T+N+ + ++ Sbjct: 67 FPLIIKNLKIEDSDTYICEVE------DQKEEVQLLVFG------LTANSDTHLLQGQSL 114 Query: 342 ALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGI-QNKLS 400 LT E ++ + + + + +TL++ + D G + C + QN+ Sbjct: 115 TLTLESPPGSSPSVQCRSPRGKNI-------QGGKTLSVSQLELQDSGTWTCTVLQNQKK 167 Query: 401 VDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLS 436 V+ +++ + S Y + G + S Sbjct: 168 VEFKIDIVVLAF------QKASSIVYKKEGEQVEFS 197 Score = 59.2 bits (141), Expect = 6e-09, Method: Composition-based stats. Identities = 42/254 (16%), Positives = 84/254 (33%), Gaps = 35/254 (13%) Query: 155 KPVEDKDAVAFTCEPETQDATYLWWVNNQSLPV--------------------SPRLQLS 194 + D V TC + + W N+ + + S R Sbjct: 4 VLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWD 63 Query: 195 NGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGEN 254 GN L + N+ D+ +Y CE ++ + + V L V + +T G++ Sbjct: 64 QGNFPLIIKNLKIEDSDTYICEVED-----QKEEVQLLVFGLT-----ANSDTHLLQGQS 113 Query: 255 LNLSCHAASNPPAQYSWFV-NGTFQQSTQELFIPNITVNNSGSYTCQA-HNSDTGLNRTT 312 L L+ + G Q + L + + + +SG++TC N + Sbjct: 114 LTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKID 173 Query: 313 VTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLS 372 + + + VE +A T E + LWW ++ + Sbjct: 174 IVVLAFQKASSIVYKK--EGEQVEFSFPLAFTVEKLTGSG-ELWWQAERASSSKSWITFD 230 Query: 373 NDNRTLTLLSVTRN 386 N+ +++ VT++ Sbjct: 231 LKNKEVSVKRVTQD 244 Score = 59.2 bits (141), Expect = 7e-09, Method: Composition-based stats. Identities = 50/363 (13%), Positives = 114/363 (31%), Gaps = 55/363 (15%) Query: 335 VEDEDAVALTCEPEIQNTTYLWWVNN--------------------QSLPVSPRLQLSND 374 + D V LTC + + W N+ S R Sbjct: 6 GKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQG 65 Query: 375 NRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLS 434 N L + ++ D Y C ++++ + +++G + S T+ G +L+ Sbjct: 66 NFPLIIKNLKIEDSDTYICEVEDQKEE------VQLLVFGLT----ANSDTHLLQGQSLT 115 Query: 435 LSCH-AASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKT 493 L+ + P+ G Q + L +S + ++SG +TC K Sbjct: 116 LTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVL--------QNQKK 167 Query: 494 ITVSAELPKPSISSNNSKPV-EDKDAVA--FTCEPEAQNTTYL---WWVNGQSLPVSPRL 547 + ++ + +S ++ + V F + T WW ++ + Sbjct: 168 VEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWI 227 Query: 548 QLSNGNRTLTLFNVTRN----DARAYVCGIQ-NSVSANRSDPVTLDVLYGPDTPIISPPD 602 N+ +++ VT++ + + + L + T + Sbjct: 228 TFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEV 287 Query: 603 SSYLSGANL---NLSCHSAS--NPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFV 657 + + A NL+C +P S ++ + ++ + G + C + Sbjct: 288 NLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLL 347 Query: 658 SNL 660 S+ Sbjct: 348 SDS 350 Score = 58.4 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 36/178 (20%), Positives = 63/178 (35%), Gaps = 36/178 (20%) Query: 515 DKDAVAFTCEPEAQNTTYLWWVNGQSL--------------------PVSPRLQLSNGNR 554 D V TC + + W N + S R GN Sbjct: 8 KGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNF 67 Query: 555 TLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLS 614 L + N+ D+ Y+C ++ ++ + V L V + + D+ L G +L L+ Sbjct: 68 PLIIKNLKIEDSDTYICEVE-----DQKEEVQLLV-----FGLTANSDTHLLQGQSLTLT 117 Query: 615 CHSASNPSPQYSWRI-NGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKS 671 S SP R G Q + L ++++ ++GT+ C V +N V+ Sbjct: 118 LESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVL-----QNQKKVEF 170 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 41/326 (12%), Positives = 94/326 (28%), Gaps = 50/326 (15%) Query: 104 NASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAV 163 N L+I+N+ D+ Y V ++ Q V+ +++N+ + ++ Sbjct: 66 NFPLIIKNLKIEDSDTYICEVED-----QKEEVQLLVF------GLTANSDTHLLQGQSL 114 Query: 164 AFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSA 223 T E + + SPR + G +TL++ + D+ ++ C Sbjct: 115 TLTLESPPGSSPSVQCR-------SPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQN--- 164 Query: 224 RRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQE 283 V + A + + GE + S + + + +Q Sbjct: 165 --QKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFS-FPLAFTVEKLTGSGELWWQAERAS 221 Query: 284 LFIPNITVNNSGSYTCQAHNSDTG------------------LNRTTVTTITVYAEPPKP 325 IT + + +T+ E Sbjct: 222 SSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTG 281 Query: 326 FITSNNSNPVEDEDAVA--LTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSV 383 + + V + LTCE + L + ++S + + +L+ Sbjct: 282 KLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLML---SLKLENKEAKVSKREKAVWVLNP 338 Query: 384 TRNDVGPYECGIQNKLSVDHSDPVIL 409 G ++C + + V + + Sbjct: 339 E---AGMWQCLLSDSGQVLLESNIKV 361 >4BSJ-A nrPDB Length = 232 Score = 59.2 bits (141), Expect = 6e-09, Method: Composition-based stats. Identities = 25/127 (19%), Positives = 46/127 (36%), Gaps = 3/127 (2%) Query: 244 PLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTF---QQSTQELFIPNITVNNSGSYTCQ 300 P+ + E + L A+ PP ++ W+ +G + S L + +T ++G+YT Sbjct: 14 PILEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLA 73 Query: 301 AHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNN 360 NS GL R + V P +++ + ALTC + Sbjct: 74 LWNSAAGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHW 133 Query: 361 QSLPVSP 367 + Sbjct: 134 RPWTPCK 140 Score = 52.6 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 22/102 (21%), Positives = 36/102 (35%), Gaps = 3/102 (2%) Query: 433 LSLSCHAASNPPAQYSWLIDGNIQQHTQE---LFISNITEKNSGLYTCQANNSASGHSRT 489 + L A+ PP ++ W DG L + +TE ++G YT NSA+G R Sbjct: 25 VKLPVKLAAYPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRN 84 Query: 490 TVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTT 531 + V+ +++ A TC Sbjct: 85 ISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAYGVPLP 126 Score = 52.6 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 25/134 (18%), Positives = 41/134 (30%), Gaps = 10/134 (7%) Query: 498 AELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTT-YLWWVNGQSLPVSPRLQLSNGNRTL 556 + + + + V + A + W+ +G++L S R L Sbjct: 4 PFISVEWLKGPILEATAGDELVKLPVKLAAYPPPEFQWYKDGKAL--SGRHS----PHAL 57 Query: 557 TLFNVTRNDARAYVCGIQNSV-SANRSDPVTLDVLYGPDTPIISPPDSSYLSGAN-LNLS 614 L VT Y + NS R+ + L V P S S + L+ Sbjct: 58 VLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALT 117 Query: 615 CHSASNPSP-QYSW 627 C + P P W Sbjct: 118 CTAYGVPLPLSIQW 131 Score = 36.1 bits (81), Expect = 0.058, Method: Composition-based stats. Identities = 24/116 (20%), Positives = 43/116 (37%), Gaps = 10/116 (8%) Query: 596 PIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQ---HTQVLFIAKITPNNNGT 652 + P + + L A+ P P++ W +G L + ++T + GT Sbjct: 10 WLKGPILEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGT 69 Query: 653 YACFVSNLATG--RNNSIVKSITV-----SASGTSPGLSAGATVGIMIGVLVGVAL 701 Y + N A G RN S+ + V +SP + + + + GV L Sbjct: 70 YTLALWNSAAGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAYGVPL 125 >2NCM-A nrPDB Length = 99 Score = 58.8 bits (140), Expect = 8e-09, Method: Composition-based stats. Identities = 24/102 (23%), Positives = 37/102 (36%), Gaps = 18/102 (17%) Query: 43 FNVAEGKEVLLLVHNLPQHLFGYSWY--KGERVDGNRQIIGYVIGTQQATPGPAYSGREI 100 +V E K L V + SW+ GE++ N+Q I V + Sbjct: 14 ISVGESKFFLCQVAGDAKDKDI-SWFSPNGEKLSPNQQRISVVWNDDDS----------- 61 Query: 101 IYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYP 142 ++L I N +D G Y V D EAT +++ Sbjct: 62 ----STLTIYNANIDDAGIYKCVVTAEDGTQSEATVNVKIFQ 99 Score = 45.3 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 14/90 (15%), Positives = 32/90 (35%), Gaps = 7/90 (7%) Query: 330 NNSNPVEDEDAVALTCEPEI-QNTTYLWWVNNQSLPVSPRLQL------SNDNRTLTLLS 382 + + ++ C+ + W + +SP Q +D+ TLT+ + Sbjct: 9 PSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLTIYN 68 Query: 383 VTRNDVGPYECGIQNKLSVDHSDPVILNVL 412 +D G Y+C + + V + + Sbjct: 69 ANIDDAGIYKCVVTAEDGTQSEATVNVKIF 98 Score = 42.6 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 15/84 (17%), Positives = 33/84 (39%), Gaps = 7/84 (8%) Query: 513 VEDKDAVAFTCEPEA--QNTTYLWWV-NGQSLPVSPRLQ----LSNGNRTLTLFNVTRND 565 + ++ F C+ ++ W+ NG+ L + + + + TLT++N +D Sbjct: 14 ISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLTIYNANIDD 73 Query: 566 ARAYVCGIQNSVSANRSDPVTLDV 589 A Y C + V + + Sbjct: 74 AGIYKCVVTAEDGTQSEATVNVKI 97 Score = 41.1 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 18/87 (20%), Positives = 25/87 (28%), Gaps = 15/87 (17%) Query: 420 ISPSYTYYRPGVNLSLSCHAASNPP-AQYSWL-IDGNI-------------QQHTQELFI 464 I PS G + C A + SW +G + L I Sbjct: 7 IVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLTI 66 Query: 465 SNITEKNSGLYTCQANNSASGHSRTTV 491 N ++G+Y C S TV Sbjct: 67 YNANIDDAGIYKCVVTAEDGTQSEATV 93 Score = 38.8 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 18/88 (20%), Positives = 28/88 (31%), Gaps = 15/88 (17%) Query: 597 IISPPDSSYLSGANLNLSCHSASNPSPQ-YSWRI-NG---IPQQ----------HTQVLF 641 I P G + C A + + SW NG P Q + L Sbjct: 6 DIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLT 65 Query: 642 IAKITPNNNGTYACFVSNLATGRNNSIV 669 I ++ G Y C V+ ++ + V Sbjct: 66 IYNANIDDAGIYKCVVTAEDGTQSEATV 93 Score = 38.4 bits (87), Expect = 0.011, Method: Composition-based stats. Identities = 16/94 (17%), Positives = 33/94 (35%), Gaps = 9/94 (9%) Query: 148 SISSNNSKPVEDKDAVAFTCEPETQDA-TYLWWVN---NQSLPVSPRLQLSNGNR---TL 200 + S V ++ F C+ + W + + P R+ + + TL Sbjct: 7 IVPSQGEISV--GESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTL 64 Query: 201 TLFNVTRNDTASYKCETQNPVSARRSDSVILNVL 234 T++N +D YKC + +V + + Sbjct: 65 TIYNANIDDAGIYKCVVTAEDGTQSEATVNVKIF 98 Score = 37.6 bits (85), Expect = 0.020, Method: Composition-based stats. Identities = 20/93 (21%), Positives = 28/93 (30%), Gaps = 15/93 (16%) Query: 242 ISPLNTSYRSGENLNLSCHAASNPP-AQYSWFV-NGTFQ-------------QSTQELFI 286 I P GE+ C A + SWF NG + L I Sbjct: 7 IVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLSPNQQRISVVWNDDDSSTLTI 66 Query: 287 PNITVNNSGSYTCQAHNSDTGLNRTTVTTITVY 319 N ++++G Y C D + TV Sbjct: 67 YNANIDDAGIYKCVVTAEDGTQSEATVNVKIFQ 99 >1TLK-A nrPDB Length = 154 Score = 58.8 bits (140), Expect = 8e-09, Method: Composition-based stats. Identities = 19/105 (18%), Positives = 33/105 (31%), Gaps = 4/105 (3%) Query: 480 NNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQN-TTYLWWVNG 538 N + + + V + A F C+ E +W+ + Sbjct: 20 ANKVENEDAFLEEVAEEKPHVKPYFTKTILDMDVVEGSAARFDCKVEGYPDPEVMWFKDD 79 Query: 539 QSLPVSPRLQL---SNGNRTLTLFNVTRNDARAYVCGIQNSVSAN 580 + S Q+ GN +LT+ V +D Y C NS+ Sbjct: 80 NPVKESRHFQIDYDEEGNCSLTISEVCGDDDAKYTCKAVNSLGEA 124 Score = 49.2 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 16/80 (20%), Positives = 25/80 (31%), Gaps = 12/80 (15%) Query: 427 YRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQ------------ELFISNITEKNSGL 474 G C P + W D N + ++ L IS + + Sbjct: 53 VVEGSAARFDCKVEGYPDPEVMWFKDDNPVKESRHFQIDYDEEGNCSLTISEVCGDDDAK 112 Query: 475 YTCQANNSASGHSRTTVKTI 494 YTC+A NS + T + Sbjct: 113 YTCKAVNSLGEATCTAELLV 132 Score = 49.2 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 18/86 (20%), Positives = 30/86 (34%), Gaps = 4/86 (4%) Query: 142 PELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQL----SNGN 197 P + + V + A F C+ E + W + + R GN Sbjct: 38 PHVKPYFTKTILDMDVVEGSAARFDCKVEGYPDPEVMWFKDDNPVKESRHFQIDYDEEGN 97 Query: 198 RTLTLFNVTRNDTASYKCETQNPVSA 223 +LT+ V +D A Y C+ N + Sbjct: 98 CSLTISEVCGDDDAKYTCKAVNSLGE 123 Score = 46.5 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 16/97 (16%), Positives = 29/97 (29%), Gaps = 18/97 (18%) Query: 238 DAPTISPL------NTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQ--------- 282 + P + P + G C P + WF + + ++ Sbjct: 36 EKPHVKPYFTKTILDMDVVEGSAARFDCKVEGYPDPEVMWFKDDNPVKESRHFQIDYDEE 95 Query: 283 ---ELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTI 316 L I + ++ YTC+A NS T + Sbjct: 96 GNCSLTISEVCGDDDAKYTCKAVNSLGEATCTAELLV 132 Score = 45.7 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 11/87 (12%), Positives = 24/87 (27%), Gaps = 12/87 (13%) Query: 602 DSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAK------------ITPNN 649 D + G+ C P P+ W + P + ++ I + ++ Sbjct: 50 DMDVVEGSAARFDCKVEGYPDPEVMWFKDDNPVKESRHFQIDYDEEGNCSLTISEVCGDD 109 Query: 650 NGTYACFVSNLATGRNNSIVKSITVSA 676 + Y C N + + Sbjct: 110 DAKYTCKAVNSLGEATCTAELLVETMG 136 Score = 43.8 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 23/114 (20%), Positives = 36/114 (31%), Gaps = 6/114 (5%) Query: 294 SGSYTCQAHNSDTGLNRTTVTTITVYAEP--PKPFITSNNSNPVEDEDAVALTCEPEIQN 351 SGS N++ N +P F + V + A C+ E Sbjct: 10 SGSSPTSPINANKVENEDAFLEEVAEEKPHVKPYFTKTILDMDVVEGSAARFDCKVEGYP 69 Query: 352 TTYLWWVN-NQSLPVSPRLQLS---NDNRTLTLLSVTRNDVGPYECGIQNKLSV 401 + W + + S Q+ N +LT+ V +D Y C N L Sbjct: 70 DPEVMWFKDDNPVKESRHFQIDYDEEGNCSLTISEVCGDDDAKYTCKAVNSLGE 123 >4Q6I-C nrPDB Length = 208 Score = 58.4 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 36/178 (20%), Positives = 63/178 (35%), Gaps = 36/178 (20%) Query: 515 DKDAVAFTCEPEAQNTTYLWWVNGQSL--------------------PVSPRLQLSNGNR 554 D V TC + + W N + S R GN Sbjct: 33 KGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNF 92 Query: 555 TLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLS 614 L + N+ D+ Y+C ++ ++ + V L V + + D+ L G +L L+ Sbjct: 93 PLIIKNLKIEDSDTYICEVE-----DQKEEVQLLV-----FGLTANSDTHLLQGQSLTLT 142 Query: 615 CHSASNPSPQYSWRI-NGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKS 671 S SP R G Q + L ++++ ++GT+ C V +N V+ Sbjct: 143 LESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVL-----QNQKKVEF 195 Score = 56.5 bits (134), Expect = 4e-08, Method: Composition-based stats. Identities = 27/189 (14%), Positives = 66/189 (34%), Gaps = 48/189 (25%) Query: 250 RSGENLNLSCHAASNPPAQYSWF----------------------------VNGTFQQST 281 + G+ + L+C A+ Q+ W + Q Sbjct: 32 KKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGN 91 Query: 282 QELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAV 341 L I N+ + +S +Y C+ ++ + V+ +T+N+ + ++ Sbjct: 92 FPLIIKNLKIEDSDTYICEVE------DQKEEVQLLVFG------LTANSDTHLLQGQSL 139 Query: 342 ALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGI-QNKLS 400 LT E ++ + + + + +TL++ + D G + C + QN+ Sbjct: 140 TLTLESPPGSSPSVQCRSPRGKNI-------QGGKTLSVSQLELQDSGTWTCTVLQNQKK 192 Query: 401 VDHSDPVIL 409 V+ +++ Sbjct: 193 VEFKIDIVV 201 Score = 53.0 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 29/174 (16%), Positives = 57/174 (32%), Gaps = 31/174 (17%) Query: 327 ITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNN--------------------QSLPVS 366 + D V LTC + + W N+ S Sbjct: 23 TQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADS 82 Query: 367 PRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTY 426 R N L + ++ D Y C ++++ + +++G + S T+ Sbjct: 83 RRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEE------VQLLVFGLT----ANSDTH 132 Query: 427 YRPGVNLSLSCH-AASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQA 479 G +L+L+ + P+ G Q + L +S + ++SG +TC Sbjct: 133 LLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTV 186 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 31/189 (16%), Positives = 61/189 (32%), Gaps = 32/189 (16%) Query: 155 KPVEDKDAVAFTCEPETQDATYLWWVNNQSLPV--------------------SPRLQLS 194 + D V TC + + W N+ + + S R Sbjct: 29 VLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWD 88 Query: 195 NGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGEN 254 GN L + N+ D+ +Y CE ++ + + V L V + +T G++ Sbjct: 89 QGNFPLIIKNLKIEDSDTYICEVED-----QKEEVQLLVFGLT-----ANSDTHLLQGQS 138 Query: 255 LNLSCHAASNPPAQYSWFV-NGTFQQSTQELFIPNITVNNSGSYTCQA-HNSDTGLNRTT 312 L L+ + G Q + L + + + +SG++TC N + Sbjct: 139 LTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKID 198 Query: 313 VTTITVYAE 321 + + Sbjct: 199 IVVLAFQKA 207 Score = 49.6 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 31/207 (14%), Positives = 62/207 (29%), Gaps = 50/207 (24%) Query: 400 SVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQ--- 456 V +++ L T + G + L+C A+ Q+ W I+ Sbjct: 4 GVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILG 63 Query: 457 -------------------------QHTQELFISNITEKNSGLYTCQANNSASGHSRTTV 491 Q L I N+ ++S Y C+ + Sbjct: 64 NQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVF 123 Query: 492 KTITVSAELPKPSISSNNSKPVEDKDAVAFTCE-PEAQNTTYLWWVNGQSLPVSPRLQLS 550 +++N+ + ++ T E P + + SPR + Sbjct: 124 G------------LTANSDTHLLQGQSLTLTLESPPGSSPSVQCR--------SPRGKNI 163 Query: 551 NGNRTLTLFNVTRNDARAYVC-GIQNS 576 G +TL++ + D+ + C +QN Sbjct: 164 QGGKTLSVSQLELQDSGTWTCTVLQNQ 190 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 22/129 (17%), Positives = 49/129 (37%), Gaps = 19/129 (14%) Query: 104 NASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAV 163 N L+I+N+ D+ Y V ++ Q V+ +++N+ + ++ Sbjct: 91 NFPLIIKNLKIEDSDTYICEVED-----QKEEVQLLVF------GLTANSDTHLLQGQSL 139 Query: 164 AFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKC-ETQNPVS 222 T E + + SPR + G +TL++ + D+ ++ C QN Sbjct: 140 TLTLESPPGSSPSVQCR-------SPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKK 192 Query: 223 ARRSDSVIL 231 +++ Sbjct: 193 VEFKIDIVV 201 >3O2D-A nrPDB Length = 188 Score = 58.4 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 36/178 (20%), Positives = 63/178 (35%), Gaps = 36/178 (20%) Query: 515 DKDAVAFTCEPEAQNTTYLWWVNGQSL--------------------PVSPRLQLSNGNR 554 D V TC + + W N + S R GN Sbjct: 8 KGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNF 67 Query: 555 TLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLS 614 L + N+ D+ Y+C ++ ++ + V L V + + D+ L G +L L+ Sbjct: 68 PLIIKNLKIEDSDTYICEVE-----DQKEEVQLLV-----FGLTANSDTHLLQGQSLTLT 117 Query: 615 CHSASNPSPQYSWRI-NGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKS 671 S SP R G Q + L ++++ ++GT+ C V +N V+ Sbjct: 118 LESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVL-----QNQKKVEF 170 Score = 56.5 bits (134), Expect = 4e-08, Method: Composition-based stats. Identities = 27/189 (14%), Positives = 66/189 (34%), Gaps = 48/189 (25%) Query: 250 RSGENLNLSCHAASNPPAQYSWF----------------------------VNGTFQQST 281 + G+ + L+C A+ Q+ W + Q Sbjct: 7 KKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGN 66 Query: 282 QELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAV 341 L I N+ + +S +Y C+ ++ + V+ +T+N+ + ++ Sbjct: 67 FPLIIKNLKIEDSDTYICEVE------DQKEEVQLLVFG------LTANSDTHLLQGQSL 114 Query: 342 ALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGI-QNKLS 400 LT E ++ + + + + +TL++ + D G + C + QN+ Sbjct: 115 TLTLESPPGSSPSVQCRSPRGKNI-------QGGKTLSVSQLELQDSGTWTCTVLQNQKK 167 Query: 401 VDHSDPVIL 409 V+ +++ Sbjct: 168 VEFKIDIVV 176 Score = 53.0 bits (125), Expect = 5e-07, Method: Composition-based stats. Identities = 29/166 (17%), Positives = 57/166 (34%), Gaps = 31/166 (18%) Query: 335 VEDEDAVALTCEPEIQNTTYLWWVNN--------------------QSLPVSPRLQLSND 374 + D V LTC + + W N+ S R Sbjct: 6 GKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQG 65 Query: 375 NRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLS 434 N L + ++ D Y C ++++ + +++G + S T+ G +L+ Sbjct: 66 NFPLIIKNLKIEDSDTYICEVEDQKEE------VQLLVFGLT----ANSDTHLLQGQSLT 115 Query: 435 LSCH-AASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQA 479 L+ + P+ G Q + L +S + ++SG +TC Sbjct: 116 LTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTV 161 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 31/189 (16%), Positives = 61/189 (32%), Gaps = 32/189 (16%) Query: 155 KPVEDKDAVAFTCEPETQDATYLWWVNNQSLPV--------------------SPRLQLS 194 + D V TC + + W N+ + + S R Sbjct: 4 VLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWD 63 Query: 195 NGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGEN 254 GN L + N+ D+ +Y CE ++ + + V L V + +T G++ Sbjct: 64 QGNFPLIIKNLKIEDSDTYICEVED-----QKEEVQLLVFGLT-----ANSDTHLLQGQS 113 Query: 255 LNLSCHAASNPPAQYSWFV-NGTFQQSTQELFIPNITVNNSGSYTCQA-HNSDTGLNRTT 312 L L+ + G Q + L + + + +SG++TC N + Sbjct: 114 LTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKID 173 Query: 313 VTTITVYAE 321 + + Sbjct: 174 IVVLAFQKA 182 Score = 47.2 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 28/182 (15%), Positives = 56/182 (30%), Gaps = 50/182 (27%) Query: 425 TYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQ---------------------------- 456 + G + L+C A+ Q+ W I+ Sbjct: 4 VLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWD 63 Query: 457 QHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDK 516 Q L I N+ ++S Y C+ + +++N+ + Sbjct: 64 QGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFG------------LTANSDTHLLQG 111 Query: 517 DAVAFTCE-PEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVC-GIQ 574 ++ T E P + + SPR + G +TL++ + D+ + C +Q Sbjct: 112 QSLTLTLESPPGSSPSVQCR--------SPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQ 163 Query: 575 NS 576 N Sbjct: 164 NQ 165 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 22/129 (17%), Positives = 49/129 (37%), Gaps = 19/129 (14%) Query: 104 NASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAV 163 N L+I+N+ D+ Y V ++ Q V+ +++N+ + ++ Sbjct: 66 NFPLIIKNLKIEDSDTYICEVED-----QKEEVQLLVF------GLTANSDTHLLQGQSL 114 Query: 164 AFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKC-ETQNPVS 222 T E + + SPR + G +TL++ + D+ ++ C QN Sbjct: 115 TLTLESPPGSSPSVQCR-------SPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKK 167 Query: 223 ARRSDSVIL 231 +++ Sbjct: 168 VEFKIDIVV 176 >5IMK-A nrPDB Length = 220 Score = 58.0 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 27/137 (19%), Positives = 44/137 (32%), Gaps = 14/137 (10%) Query: 374 DNRTLTLLSVTRNDVGPYECGIQ------NKLSVDHSDPVILN--VLYGPDDPTISPSYT 425 + +L L ++ +D Y C + N++ D + + + P T S Sbjct: 82 GDVSLQLSTLEMDDRSHYTCEVTWQTPDGNQVVRDKITELRVQKLSVSKPTVTTGSGYGF 141 Query: 426 YYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHT------QELFISNITEKNSGLYTCQA 479 G+ +SL C A +PP Y W Q L +SG Y C A Sbjct: 142 TVPQGMRISLQCQARGSPPISYIWYKQQTNNQEPIKVATLSTLLFKPAVIADSGSYFCTA 201 Query: 480 NNSASGHSRTTVKTITV 496 + + V Sbjct: 202 KGQVGSEQHSDIVKFVV 218 Score = 53.4 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 23/134 (17%), Positives = 42/134 (31%), Gaps = 9/134 (6%) Query: 104 NASLLIQNIIQNDTGFYTLHVI----KSDLVNEEATGQFRV---YPELPKPSISSNNSKP 156 + SL + + +D YT V + V + + RV P + S Sbjct: 83 DVSLQLSTLEMDDRSHYTCEVTWQTPDGNQVVRDKITELRVQKLSVSKPTVTTGSGYGFT 142 Query: 157 VEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCE 216 V ++ C+ W Q+ P + TL D+ SY C Sbjct: 143 VPQGMRISLQCQARGSPPISYIWYKQQTNNQEPIKVATLS--TLLFKPAVIADSGSYFCT 200 Query: 217 TQNPVSARRSDSVI 230 + V + + ++ Sbjct: 201 AKGQVGSEQHSDIV 214 Score = 53.4 bits (126), Expect = 3e-07, Method: Composition-based stats. Identities = 24/139 (17%), Positives = 45/139 (32%), Gaps = 16/139 (11%) Query: 462 LFISNITEKNSGLYTCQAN------NSASGHSRTTVKTITVSAELPKPSISSNNSKPVED 515 L +S + + YTC+ N T ++ +S P + S V Sbjct: 86 LQLSTLEMDDRSHYTCEVTWQTPDGNQVVRDKITELRVQKLSVSKPTVTTGSGYGFTVPQ 145 Query: 516 KDAVAFTCEPEAQNT-TYLWWV---NGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVC 571 ++ C+ +Y+W+ N Q L TL D+ +Y C Sbjct: 146 GMRISLQCQARGSPPISYIWYKQQTNNQEPIKVATLS------TLLFKPAVIADSGSYFC 199 Query: 572 GIQNSVSANRSDPVTLDVL 590 + V + + + V+ Sbjct: 200 TAKGQVGSEQHSDIVKFVV 218 Score = 52.6 bits (124), Expect = 6e-07, Method: Composition-based stats. Identities = 31/137 (22%), Positives = 47/137 (34%), Gaps = 14/137 (10%) Query: 196 GNRTLTLFNVTRNDTASYKCETQ----NPVSARRSDSVILNV----LYGPDAPTISPLNT 247 G+ +L L + +D + Y CE + R L V + P T S Sbjct: 82 GDVSLQLSTLEMDDRSHYTCEVTWQTPDGNQVVRDKITELRVQKLSVSKPTVTTGSGYGF 141 Query: 248 SYRSGENLNLSCHAASNPPAQYSWFVNGTFQQST------QELFIPNITVNNSGSYTCQA 301 + G ++L C A +PP Y W+ T Q L + +SGSY C A Sbjct: 142 TVPQGMRISLQCQARGSPPISYIWYKQQTNNQEPIKVATLSTLLFKPAVIADSGSYFCTA 201 Query: 302 HNSDTGLNRTTVTTITV 318 + + V Sbjct: 202 KGQVGSEQHSDIVKFVV 218 Score = 51.1 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 24/137 (17%), Positives = 42/137 (30%), Gaps = 14/137 (10%) Query: 552 GNRTLTLFNVTRNDARAYVCGIQ------NSVSANR--SDPVTLDVLYGPDTPIISPPDS 603 G+ +L L + +D Y C + N V ++ V + P S Sbjct: 82 GDVSLQLSTLEMDDRSHYTCEVTWQTPDGNQVVRDKITELRVQKLSVSKPTVTTGSGYGF 141 Query: 604 SYLSGANLNLSCHSASNPSPQYSWRINGIPQQHT------QVLFIAKITPNNNGTYACFV 657 + G ++L C + +P Y W Q L ++G+Y C Sbjct: 142 TVPQGMRISLQCQARGSPPISYIWYKQQTNNQEPIKVATLSTLLFKPAVIADSGSYFCTA 201 Query: 658 SNLATGRNNSIVKSITV 674 +S + V Sbjct: 202 KGQVGSEQHSDIVKFVV 218 Score = 45.7 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 27/138 (19%), Positives = 43/138 (31%), Gaps = 9/138 (6%) Query: 281 TQELFIPNITVNNSGSYTCQAH---NSDTGLNRTTVTTITVY---AEPPKPFITSNNSNP 334 L + + +++ YTC+ + R +T + V P S Sbjct: 83 DVSLQLSTLEMDDRSHYTCEVTWQTPDGNQVVRDKITELRVQKLSVSKPTVTTGSGYGFT 142 Query: 335 VEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECG 394 V ++L C+ W Q+ P TL D G Y C Sbjct: 143 VPQGMRISLQCQARGSPPISYIWYKQQTNNQEPIK--VATLSTLLFKPAVIADSGSYFCT 200 Query: 395 IQNKL-SVDHSDPVILNV 411 + ++ S HSD V V Sbjct: 201 AKGQVGSEQHSDIVKFVV 218 >3O3U-N nrPDB Length = 581 Score = 56.5 bits (134), Expect = 4e-08, Method: Composition-based stats. Identities = 26/141 (18%), Positives = 45/141 (31%), Gaps = 15/141 (10%) Query: 336 EDEDAVALTCE-PEIQNTTYLWWVNNQSLPVSPRLQLSN------------DNRTLTLLS 382 + + L C+ + L W N + ++ N +L L + Sbjct: 379 RIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPA 438 Query: 383 VTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAA-- 440 V D G + C N+ + + V P P I S + GV + + Sbjct: 439 VGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEG 498 Query: 441 SNPPAQYSWLIDGNIQQHTQE 461 S P SW +DG ++ Sbjct: 499 SYPAGTLSWHLDGKPLVPNEK 519 Score = 52.6 bits (124), Expect = 6e-07, Method: Composition-based stats. Identities = 23/138 (16%), Positives = 43/138 (31%), Gaps = 15/138 (10%) Query: 155 KPVEDKDAVAFTC-EPETQDATYLWWVNNQSLPVSPRLQLSNG------------NRTLT 201 + + C + L W N + ++ G N +L Sbjct: 376 ITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLF 435 Query: 202 LFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNL-SCH 260 L V D ++C+ N + + V P P I + +G + +C Sbjct: 436 LPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCV 495 Query: 261 AASNPPA-QYSWFVNGTF 277 + + PA SW ++G Sbjct: 496 SEGSYPAGTLSWHLDGKP 513 Score = 49.9 bits (117), Expect = 4e-06, Method: Composition-based stats. Identities = 23/140 (16%), Positives = 40/140 (28%), Gaps = 15/140 (10%) Query: 509 NSKPVEDKDAVAFTCE-PEAQNTTYLWWVNGQSLPVSPRLQLSNG------------NRT 555 + + + C+ + L W + ++ G N + Sbjct: 374 QNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGS 433 Query: 556 LTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTP-IISPPDSSYLSGANLNLS 614 L L V D + C N + V P P I+ N + Sbjct: 434 LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGT 493 Query: 615 CHSASN-PSPQYSWRINGIP 633 C S + P+ SW ++G P Sbjct: 494 CVSEGSYPAGTLSWHLDGKP 513 Score = 49.2 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 25/147 (17%), Positives = 47/147 (31%), Gaps = 24/147 (16%) Query: 423 SYTYYRPGVNLSLSCH-AASNPPAQYSWLIDGNIQQH--------------------TQE 461 R G L L C A PP + W ++ + Sbjct: 374 QNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGS 433 Query: 462 LFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAF 521 LF+ + ++ G++ CQA N +++ + + S + + V Sbjct: 434 LFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVG- 492 Query: 522 TCEPEAQNT--TYLWWVNGQSLPVSPR 546 TC E T W ++G+ L + + Sbjct: 493 TCVSEGSYPAGTLSWHLDGKPLVPNEK 519 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 38/154 (24%), Positives = 51/154 (33%), Gaps = 23/154 (14%) Query: 246 NTSYRSGENLNLSCHAASNPPAQ-YSWFVN--------------GTFQQSTQ------EL 284 N + R GE L L C A P Q W +N G S L Sbjct: 375 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSL 434 Query: 285 FIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALT 344 F+P + + + G + CQA N G + + VY P KP I + S T Sbjct: 435 FLPAVGIQDEGIFRCQAMN-RNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGT 493 Query: 345 CEPEIQ-NTTYLWWVNNQSLPVSPRLQLSNDNRT 377 C E L W + V +S +T Sbjct: 494 CVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQT 527 Score = 47.2 bits (110), Expect = 3e-05, Method: Composition-based stats. Identities = 21/129 (16%), Positives = 43/129 (33%), Gaps = 4/129 (3%) Query: 72 RVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVN 131 +++ R V+ Q P + + + PN SL + + D G + + + Sbjct: 402 KLNTGRTEAWKVLSPQGGGPWDSVA---RVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKE 458 Query: 132 EEATGQFRVYP-ELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPR 190 ++ + RVY + S + + V + A L W + V Sbjct: 459 TKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNE 518 Query: 191 LQLSNGNRT 199 +S +T Sbjct: 519 KGVSVKEQT 527 Score = 33.4 bits (74), Expect = 0.37, Method: Composition-based stats. Identities = 15/87 (17%), Positives = 25/87 (28%), Gaps = 21/87 (24%) Query: 602 DSSYLSGANLNLSCH-SASNPSPQYSWRIN--------------GIPQQH------TQVL 640 + + G L L C + P + W++N G P L Sbjct: 375 NITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSL 434 Query: 641 FIAKITPNNNGTYACFVSNLATGRNNS 667 F+ + + G + C N S Sbjct: 435 FLPAVGIQDEGIFRCQAMNRNGKETKS 461 >1VCA-A nrPDB Length = 202 Score = 56.1 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 23/122 (18%), Positives = 47/122 (38%), Gaps = 2/122 (1%) Query: 145 PKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFN 204 K + + + D+V+ TC ++ + W P++ ++ TLT+ Sbjct: 1 FKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNP 60 Query: 205 VTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASN 264 V+ + SY C S + + + + P P I L+ +G+ + + C A Sbjct: 61 VSFGNEHSYLCTATCE-SRKLEKGIQVEIYSFPKDPEIH-LSGPLEAGKPITVKCSVADV 118 Query: 265 PP 266 P Sbjct: 119 YP 120 Score = 51.1 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 19/108 (17%), Positives = 40/108 (37%), Gaps = 2/108 (1%) Query: 511 KPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYV 570 + D+V+ TC + + W P++ ++ TLT+ V+ + +Y+ Sbjct: 11 YLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYL 70 Query: 571 CGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSA 618 C S + +++ P P I +G + + C A Sbjct: 71 CTATCE-SRKLEKGIQVEIYSFPKDPEI-HLSGPLEAGKPITVKCSVA 116 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 25/122 (20%), Positives = 45/122 (36%), Gaps = 2/122 (1%) Query: 323 PKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLS 382 K T + + D+V+LTC + + W P++ ++ TLT+ Sbjct: 1 FKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNP 60 Query: 383 VTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASN 442 V+ + Y C + S + + + P DP I S G +++ C A Sbjct: 61 VSFGNEHSYLCTATCE-SRKLEKGIQVEIYSFPKDPEIHLSGPLEA-GKPITVKCSVADV 118 Query: 443 PP 444 P Sbjct: 119 YP 120 Score = 43.8 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 23/119 (19%), Positives = 40/119 (33%), Gaps = 12/119 (10%) Query: 238 DAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFV------NGTFQ--QSTQELFIPNI 289 T + G++++L+C +SW NG +T L + + Sbjct: 2 KIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPV 61 Query: 290 TVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPE 348 + N SY C A + +Y+ P P I S P+E + + C Sbjct: 62 SFGNEHSYLCTAT--CESRKLEKGIQVEIYSFPKDPEIH--LSGPLEAGKPITVKCSVA 116 Score = 37.6 bits (85), Expect = 0.019, Method: Composition-based stats. Identities = 24/103 (23%), Positives = 37/103 (35%), Gaps = 8/103 (7%) Query: 606 LSGANLNLSCHSASNPSPQYSWR------INGIPQQH--TQVLFIAKITPNNNGTYACFV 657 G +++L+C + SP +SWR +NG T L + ++ N +Y C Sbjct: 14 QIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTA 73 Query: 658 SNLATGRNNSIVKSITVSASGTSPGLSAGATVGIMIGVLVGVA 700 + + I I LS G I V VA Sbjct: 74 TCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVA 116 >2IFG-A nrPDB Length = 347 Score = 54.9 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 41/217 (18%), Positives = 69/217 (31%), Gaps = 42/217 (19%) Query: 477 CQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWV 536 C + + T+ ++P + V+ D V C+ E + W+ Sbjct: 142 CHGQGPLAHMPNASCGVPTLKVQVP--------NASVDVGDDVLLRCQVEGRGLEQAGWI 193 Query: 537 NGQSLPVSPRLQLSNG--NRTLTLFNVTRNDAR-AYVCGIQNSVSANRSDPVTLDVLYGP 593 + L S + S G + LTL NVT + R C +N V V ++V + Sbjct: 194 LTE-LEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRA-EVSVQVNVSFPA 251 Query: 594 DTPIISPPDSSYLSGANLNLSC---HSASNPSPQYSWRINGIPQQHTQVLFIAKITPN-- 648 + + + + C P+P W NG T +F + P Sbjct: 252 SVQLHTAVEMHHW--------CIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAAN 303 Query: 649 ----------------NNGTYACFVSNLATGRNNSIV 669 NNG Y +N + SI+ Sbjct: 304 ETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIM 340 Score = 47.6 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 36/195 (18%), Positives = 65/195 (33%), Gaps = 33/195 (16%) Query: 323 PKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSN-DNRTLTLL 381 P + N+ V+ D V L C+ E + W+ + + ++ + LTL Sbjct: 159 PTLKVQVPNA-SVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLA 217 Query: 382 SVTRN-DVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSC--- 437 +VT + + C +N + V +NV + P+ V + C Sbjct: 218 NVTSDLNRKNVTCWAENDVG-RAEVSVQVNVSF--------PASVQLHTAVEMHHWCIPF 268 Query: 438 HAASNPPAQYSWLIDGNIQQHTQELF------------------ISNITEKNSGLYTCQA 479 P WL +G++ T +F ++ T N+G YT A Sbjct: 269 SVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLA 328 Query: 480 NNSASGHSRTTVKTI 494 N S + + Sbjct: 329 ANPFGQASASIMAAF 343 Score = 43.4 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 39/184 (21%), Positives = 61/184 (33%), Gaps = 36/184 (19%) Query: 156 PVEDKDAVAFTCEPETQDATYLWWVN---NQSLPVSPRLQLSNGNRTLTLFNVTRN-DTA 211 V+ D V C+ E + W+ QS V L + LTL NVT + + Sbjct: 169 SVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLG--LTLANVTSDLNRK 226 Query: 212 SYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSC---HAASNPPAQ 268 + C +N V R SV +NV + P + + ++ C P Sbjct: 227 NVTCWAENDVG-RAEVSVQVNVSF--------PASVQLHTAVEMHHWCIPFSVDGQPAPS 277 Query: 269 YSWFVNGTFQQSTQ------------------ELFIPNITVNNSGSYTCQAHNSDTGLNR 310 W NG+ T L + T N+G+YT A N + Sbjct: 278 LRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASA 337 Query: 311 TTVT 314 + + Sbjct: 338 SIMA 341 >4FMK-A nrPDB Length = 225 Score = 54.9 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 27/143 (18%), Positives = 49/143 (34%), Gaps = 11/143 (7%) Query: 279 QSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDE 338 L + V + G+YTC+ G R VT + V A+P + + + Sbjct: 80 LRDATLAFRGLRVEDEGNYTCEFATFPNGTRRG-VTWLRVIAQPENHAEAQEVT--IGPQ 136 Query: 339 DAVALTCEPEIQNTTY-LWWVNNQSLPVSPRLQLSNDNRTLTLLS------VTRNDVGPY 391 C + W+++ + T+T++S V R D Sbjct: 137 SVAVARCVSTGGRPPARITWISSLGGEAKDTQEPGIQAGTVTIISRYSLVPVGRADGVKV 196 Query: 392 ECGIQNK-LSVDHSDPVILNVLY 413 C ++++ PV L+V Y Sbjct: 197 TCRVEHESFEEPILLPVTLSVRY 219 Score = 49.9 bits (117), Expect = 4e-06, Method: Composition-based stats. Identities = 25/151 (16%), Positives = 43/151 (28%), Gaps = 13/151 (8%) Query: 450 LIDGNIQQHTQELFISNITEKNSGLYTCQ-ANNSASGHSRTTVKTITVSAELPKPSISSN 508 + N L + ++ G YTC+ A T + E + + Sbjct: 73 RPETNADLRDATLAFRGLRVEDEGNYTCEFATFPNGTRRGVTWLRVIAQPE----NHAEA 128 Query: 509 NSKPVEDKDAVAFTCEPEAQNTTYL--WWVNGQSLPVSPRLQ-LSNGNRTL----TLFNV 561 + + C W + + + G T+ +L V Sbjct: 129 QEVTIGPQSVAVARCVSTGGRPPARITWISSLGGEAKDTQEPGIQAGTVTIISRYSLVPV 188 Query: 562 TRNDARAYVCGIQN-SVSANRSDPVTLDVLY 591 R D C +++ S PVTL V Y Sbjct: 189 GRADGVKVTCRVEHESFEEPILLPVTLSVRY 219 Score = 37.2 bits (84), Expect = 0.022, Method: Composition-based stats. Identities = 20/142 (14%), Positives = 39/142 (27%), Gaps = 10/142 (7%) Query: 102 YPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKD 161 +A+L + + D G YT RV + + + + + Sbjct: 80 LRDATLAFRGLRVEDEGNYTCEFATFPNGTRRGVTWLRVIAQ--PENHAEAQEVTIGPQS 137 Query: 162 AVAFTCEPETQDATY-LWWVNNQSLPVSPRLQLSNGNRTLTLF------NVTRNDTASYK 214 C + W+++ + T+T+ V R D Sbjct: 138 VAVARCVSTGGRPPARITWISSLGGEAKDTQEPGIQAGTVTIISRYSLVPVGRADGVKVT 197 Query: 215 CETQN-PVSARRSDSVILNVLY 235 C ++ V L+V Y Sbjct: 198 CRVEHESFEEPILLPVTLSVRY 219 Score = 36.8 bits (83), Expect = 0.036, Method: Composition-based stats. Identities = 13/76 (17%), Positives = 23/76 (30%), Gaps = 2/76 (2%) Query: 553 NRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLN 612 + TL + D Y C + R L V+ P+ + + + Sbjct: 82 DATLAFRGLRVEDEGNYTCEFATFPNGTRRGVTWLRVIAQPENH-AEAQEVTIGPQSVAV 140 Query: 613 LSCHSA-SNPSPQYSW 627 C S P + +W Sbjct: 141 ARCVSTGGRPPARITW 156 Score = 35.3 bits (79), Expect = 0.088, Method: Composition-based stats. Identities = 34/193 (17%), Positives = 55/193 (28%), Gaps = 15/193 (7%) Query: 313 VTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLS 372 + + PP S + D VA + + ++ V R + + Sbjct: 18 TVELPCHLLPPTTERVSQVTWQRLDGTVVAAFHPSFGVDFPNSQFSKDRLSFVRARPETN 77 Query: 373 ND--NRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPG 430 D + TL + D G Y C + + + L P G Sbjct: 78 ADLRDATLAFRGLRVEDEGNYTCE---FATFPNGTRRGVTWLRVIAQPENHAEAQEVTIG 134 Query: 431 VN--LSLSC-HAASNPPAQYSWLID-GNIQQHTQELFISNITEKNSGLYTCQANNSASGH 486 C PPA+ +W+ G + TQE I +G T + S Sbjct: 135 PQSVAVARCVSTGGRPPARITWISSLGGEAKDTQEPGIQ------AGTVTIISRYSLVPV 188 Query: 487 SRTTVKTITVSAE 499 R +T E Sbjct: 189 GRADGVKVTCRVE 201 >3MJ9-A nrPDB Length = 268 Score = 54.6 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 43/255 (16%), Positives = 90/255 (35%), Gaps = 51/255 (20%) Query: 43 FNVAEGKEVLLLVHNLPQ-HLFGYSW-YKGERVDGNRQIIGYVIGTQQATPGPAYSGR-- 98 +V E + +V + H+ W + ++ D + ++ Y + + P + R Sbjct: 17 VHVGESVLMGCVVQRTEEKHVDRVDWLFSKDKDDASEYVLFYY--SNLSVPTGRFQNRSH 74 Query: 99 ---EIIYPNASLLIQNIIQNDTGFYTLHV-IKSDLVNEEATGQFRVYPELPKPSISSNNS 154 + + + SLL+Q++ + D G YT + +K++ + + + V PE P+ Sbjct: 75 LVGDTFHNDGSLLLQDVQKADEGIYTCEIRLKNESMVMKKPVELWVLPEEPR-------D 127 Query: 155 KPVEDKDAVAFTCEPETQDATYLWWVN-----------NQSLPVSPRLQ----------- 192 V D C ++ + + VN L ++ Sbjct: 128 LRVRVGDTTQMRCSIQSTEEKRVTKVNWMFSSGSHTEEETVLSYDSNMRSGKFQSLGRFR 187 Query: 193 --------LSNGNRTLTLFNVTRNDTASYKCETQNPVSA-RRSDSVILNVLYGPDAPTIS 243 +S + ++ L V +D Y C V +++L+V+ TIS Sbjct: 188 NRVDLTGDISRNDGSIKLQTVKESDQGIYTCSI--YVGKLESRKTIVLHVVQDEFQRTIS 245 Query: 244 PLNTSYRSGENLNLS 258 P G+ L+ Sbjct: 246 PT-PPTDKGQQGILN 259 Score = 52.2 bits (123), Expect = 6e-07, Method: Composition-based stats. Identities = 27/175 (15%), Positives = 47/175 (26%), Gaps = 40/175 (22%) Query: 458 HTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKD 517 + L + ++ + + G+YTC+ + V E P V D Sbjct: 82 NDGSLLLQDVQKADEGIYTCEIRLKNESMVMKKPVELWVLPEEP-------RDLRVRVGD 134 Query: 518 AVAFTCEPEAQN----TTYLWWVNGQSLPVSPRL-------------------------- 547 C ++ T W + S + Sbjct: 135 TTQMRCSIQSTEEKRVTKVNWMFSSGSHTEEETVLSYDSNMRSGKFQSLGRFRNRVDLTG 194 Query: 548 QLSNGNRTLTLFNVTRNDARAYVCGIQNSVSA-NRSDPVTLDVLYGPDTPIISPP 601 +S + ++ L V +D Y C I V + L V+ ISP Sbjct: 195 DISRNDGSIKLQTVKESDQGIYTCSI--YVGKLESRKTIVLHVVQDEFQRTISPT 247 Score = 49.2 bits (115), Expect = 5e-06, Method: Composition-based stats. Identities = 40/262 (15%), Positives = 78/262 (29%), Gaps = 72/262 (27%) Query: 142 PELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYL----W---------------WVNN 182 + S+ V ++V C + + ++ W + +N Sbjct: 2 SQGLPGLTVSSPQLRVHVGESVLMGCVVQRTEEKHVDRVDWLFSKDKDDASEYVLFYYSN 61 Query: 183 QSLPV---SPRLQL----SNGNRTLTLFNVTRNDTASYKCETQ-NPVSARRSDSVILNVL 234 S+P R L + + +L L +V + D Y CE + S V L VL Sbjct: 62 LSVPTGRFQNRSHLVGDTFHNDGSLLLQDVQKADEGIYTCEIRLKNESMVMKKPVELWVL 121 Query: 235 YGPDAPTISPLNTSYRSGENLNLSCHAASN---PPAQYSW-------------------- 271 P+ P + R G+ + C S + +W Sbjct: 122 --PEEPR----DLRVRVGDTTQMRCSIQSTEEKRVTKVNWMFSSGSHTEEETVLSYDSNM 175 Query: 272 ----------FVN-----GTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTI 316 F N G ++ + + + ++ G YTC + +T V + Sbjct: 176 RSGKFQSLGRFRNRVDLTGDISRNDGSIKLQTVKESDQGIYTCSIYVGKLESRKTIVLHV 235 Query: 317 TVYAEPPKPFITSNNSNPVEDE 338 V E + + ++ + Sbjct: 236 -VQDEFQRTISPTPPTDKGQQG 256 Score = 48.0 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 30/192 (15%), Positives = 60/192 (31%), Gaps = 39/192 (20%) Query: 275 GTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 G + L + ++ + G YTC+ + + + V E P+ Sbjct: 77 GDTFHNDGSLLLQDVQKADEGIYTCEIRLKNESMVMKKPVELWVLPEEPRDLR------- 129 Query: 335 VEDEDAVALTCEPEIQNTTYL----WWVNNQSLPVSPRLQ-------------------- 370 V D + C + + W ++ S + Sbjct: 130 VRVGDTTQMRCSIQSTEEKRVTKVNWMFSSGSHTEEETVLSYDSNMRSGKFQSLGRFRNR 189 Query: 371 ------LSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSY 424 +S ++ ++ L +V +D G Y C I ++L+V+ TISP+ Sbjct: 190 VDLTGDISRNDGSIKLQTVKESDQGIYTCSIYVGKLESRKT-IVLHVVQDEFQRTISPTP 248 Query: 425 TYYRPGVNLSLS 436 + G L+ Sbjct: 249 PTDK-GQQGILN 259 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 35/240 (14%), Positives = 65/240 (27%), Gaps = 74/240 (30%) Query: 323 PKPFITSNNSNPVEDEDAVALTCEPEIQNTTYL----WWVNNQSLPVSPRLQL------- 371 P ++S V ++V + C + ++ W + S + Sbjct: 6 PGLTVSSPQ-LRVHVGESVLMGCVVQRTEEKHVDRVDWLFSKDKDDASEYVLFYYSNLSV 64 Query: 372 ---------------SNDNRTLTLLSVTRNDVGPYECGIQNKLSVDH-SDPVILNVLYGP 415 +++ +L L V + D G Y C I+ K PV L VL Sbjct: 65 PTGRFQNRSHLVGDTFHNDGSLLLQDVQKADEGIYTCEIRLKNESMVMKKPVELWVLPE- 123 Query: 416 DDPTISPSYTYYRPGVNLSLSCHAASNPP---AQYSWLID-------------------- 452 P R G + C S + +W+ Sbjct: 124 -----EPRDLRVRVGDTTQMRCSIQSTEEKRVTKVNWMFSSGSHTEEETVLSYDSNMRSG 178 Query: 453 ---------------GNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVS 497 G+I ++ + + + E + G+YTC + + V Sbjct: 179 KFQSLGRFRNRVDLTGDISRNDGSIKLQTVKESDQGIYTC--SIYVGKLESRKTIVLHVV 236 >2VAJ-A nrPDB Length = 93 Score = 54.2 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 19/111 (17%), Positives = 36/111 (32%), Gaps = 22/111 (19%) Query: 34 AKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWY--KGERVDGNRQIIGYVIGTQQATP 91 +++ +V E K P+ + WY +GE++ ++++ G Sbjct: 3 VTISLSKVELSVGESKFFTCTAIGEPESI---DWYNPQGEKIISTQRVVVQKEGV----- 54 Query: 92 GPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYP 142 + L I N D G Y + +EAT +Y Sbjct: 55 ------------RSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQ 93 Score = 49.2 bits (115), Expect = 7e-06, Method: Composition-based stats. Identities = 22/91 (24%), Positives = 30/91 (32%), Gaps = 13/91 (14%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFV-NGTFQQST-----------QELFIPN 288 TIS GE+ +C A P W+ G ST L I N Sbjct: 4 TISLSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYN 62 Query: 289 ITVNNSGSYTCQAHNSDTGLNRTTVTTITVY 319 + ++G Y CQA ++ TV Sbjct: 63 ANIEDAGIYRCQATDAKGQTQEATVVLEIYQ 93 Score = 46.5 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 13/77 (16%), Positives = 30/77 (38%), Gaps = 3/77 (3%) Query: 160 KDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNG---NRTLTLFNVTRNDTASYKCE 216 ++ FTC + + W+ +S + + LT++N D Y+C+ Sbjct: 15 GESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQ 74 Query: 217 TQNPVSARRSDSVILNV 233 + + +V+L + Sbjct: 75 ATDAKGQTQEATVVLEI 91 Score = 46.5 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 15/78 (19%), Positives = 32/78 (41%), Gaps = 3/78 (3%) Query: 516 KDAVAFTCEPEAQNTTYLWWV-NGQSLPVSPRLQL--SNGNRTLTLFNVTRNDARAYVCG 572 ++ FTC + + W+ G+ + + R+ + LT++N DA Y C Sbjct: 15 GESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQ 74 Query: 573 IQNSVSANRSDPVTLDVL 590 ++ + V L++ Sbjct: 75 ATDAKGQTQEATVVLEIY 92 Score = 44.2 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 12/77 (15%), Positives = 25/77 (32%), Gaps = 3/77 (3%) Query: 338 EDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRT---LTLLSVTRNDVGPYECG 394 ++ TC + + W+ +S + + LT+ + D G Y C Sbjct: 15 GESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQ 74 Query: 395 IQNKLSVDHSDPVILNV 411 + V+L + Sbjct: 75 ATDAKGQTQEATVVLEI 91 Score = 44.2 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 20/85 (23%), Positives = 28/85 (32%), Gaps = 13/85 (15%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQYSWL-IDGNIQQH-----------TQELFISN 466 TIS S G + +C A P W G L I N Sbjct: 4 TISLSKVELSVGESKFFTCTAIGEPE-SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYN 62 Query: 467 ITEKNSGLYTCQANNSASGHSRTTV 491 +++G+Y CQA ++ TV Sbjct: 63 ANIEDAGIYRCQATDAKGQTQEATV 87 Score = 38.4 bits (87), Expect = 0.011, Method: Composition-based stats. Identities = 14/88 (15%), Positives = 21/88 (23%), Gaps = 19/88 (21%) Query: 598 ISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHT---------------QVLFI 642 IS G + +C + P W PQ L I Sbjct: 5 ISLSKVELSVGESKFFTCTAIGEPE-SIDWYN---PQGEKIISTQRVVVQKEGVRSRLTI 60 Query: 643 AKITPNNNGTYACFVSNLATGRNNSIVK 670 + G Y C ++ + V Sbjct: 61 YNANIEDAGIYRCQATDAKGQTQEATVV 88 >1FSK-B nrPDB Length = 214 Score = 53.0 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 38/202 (18%), Positives = 65/202 (32%), Gaps = 39/202 (19%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSL---------PVSPRLQLSND- 374 S S V + V L+C+ TY++W + P + + + Sbjct: 3 VLTQSPKSMSVSVGERVTLSCKASENVDTYVFWFQQKPDQSPKLLLYGPSNRYTGVPDRF 62 Query: 375 -------NRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYT 425 + TLT+ SV D+ Y CG L + PT+S P + Sbjct: 63 TGSGSTTDFTLTISSVQAEDLADYHCGQSYSYPYTFGGGTKLEIKRADAAPTVSIFPPSS 122 Query: 426 YYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFIS 465 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 123 EQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLT 182 Query: 466 NITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 183 KDEYERHNSYTCEATHKTSTSP 204 Score = 46.5 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 35/198 (17%), Positives = 63/198 (31%), Gaps = 39/198 (19%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQS-----------------LPVSPRLQ 548 S S V + V +C+ TY++W + +P Sbjct: 6 QSPKSMSVSVGERVTLSCKASENVDTYVFWFQQKPDQSPKLLLYGPSNRYTGVPDRFTGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSYL 606 S + TLT+ +V D Y CG S L++ P +S PP S L Sbjct: 66 GSTTDFTLTISSVQAEDLADYHCGQSYSYPYTFGGGTKLEIKRADAAPTVSIFPPSSEQL 125 Query: 607 SGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKIT 646 + ++ C + + W+I+G +Q+ L + K Sbjct: 126 TSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDE 185 Query: 647 PNNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 YERHNSYTCEATHKTSTS 203 Score = 42.6 bits (98), Expect = 7e-04, Method: Composition-based stats. Identities = 40/202 (19%), Positives = 66/202 (32%), Gaps = 43/202 (21%) Query: 149 ISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQL--------------- 193 S S V + V +C+ TY++W + SP+L L Sbjct: 5 TQSPKSMSVSVGERVTLSCKASENVDTYVFWFQQKPD-QSPKLLLYGPSNRYTGVPDRFT 63 Query: 194 ---SNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNT 247 S + TLT+ +V D A Y C L + APT+S P + Sbjct: 64 GSGSTTDFTLTISSVQAEDLADYHCGQSYSYPYTFGGGTKLEIKRADAAPTVSIFPPSSE 123 Query: 248 SYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFIP 287 SG ++ C + P W ++G+ +Q+ + L + Sbjct: 124 QLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLT 182 Query: 288 NITVNNSGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 183 KDEYERHNSYTCEATHKTSTSP 204 Score = 39.2 bits (89), Expect = 0.007, Method: Composition-based stats. Identities = 39/204 (19%), Positives = 57/204 (27%), Gaps = 49/204 (24%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP + S GE + LSC A+ N WF G Sbjct: 5 TQSPKSMSVSVGERVTLSCKASENVDTYVFWFQQKPDQSPKLLLYGPSNRYTGVPDRFTG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTC-QAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 + + L I ++ + Y C Q+++ T I P I +S Sbjct: 65 SGSTTDFTLTISSVQAEDLADYHCGQSYSYPYTFGGGTKLEIKRADAAPTVSIFPPSSEQ 124 Query: 335 VEDEDAVALTC-----------------EPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRT 377 + ++ C E QN L +Q S + T Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGV-LNSWTDQDSKDSTYSM----SST 178 Query: 378 LTLLSVTRNDVGPYECGIQNKLSV 401 LTL Y C +K S Sbjct: 179 LTLTKDEYERHNSYTCEATHKTST 202 >1DR9-A nrPDB Length = 201 Score = 52.6 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 27/159 (16%), Positives = 50/159 (31%), Gaps = 27/159 (16%) Query: 155 KPVEDKDAVAFTCE----PETQDATYLWWVNNQSL------------PVSPRLQLSNGNR 198 E K+ +C E T ++W + + P + + Sbjct: 4 VTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITN 63 Query: 199 TLTL--FNVTRNDTASYKCETQNPV--SARRSDSVILNVLYGPDAPTISPLNTSYRSGEN 254 L++ + +D +Y+C + +R + + D PT S + + Sbjct: 64 NLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNI 123 Query: 255 LNLSCHAA-SNPPAQYSWFVNGTFQQSTQELFIPNITVN 292 + C + P SW NG EL N TV+ Sbjct: 124 RRIICSTSGGFPEPHLSWLENGE------ELNAINTTVS 156 Score = 44.2 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 23/121 (19%), Positives = 41/121 (33%), Gaps = 4/121 (3%) Query: 93 PAYSGREI--IYPNASLLIQNIIQNDTGFYTLHVIK--SDLVNEEATGQFRVYPELPKPS 148 P Y R I I N S++I + +D G Y V+K D E + + + P+ Sbjct: 51 PEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPT 110 Query: 149 ISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRN 208 S ++ + +L W+ N + +S T ++ Sbjct: 111 PSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETELYAVSSKL 170 Query: 209 D 209 D Sbjct: 171 D 171 Score = 44.2 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 27/141 (19%), Positives = 46/141 (32%), Gaps = 25/141 (17%) Query: 514 EDKDAVAFTC----EPEAQNTTYLWWVNGQS------------LPVSPRLQL--SNGNRT 555 E K+ +C E T ++W + P + N + Sbjct: 7 EVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLS 66 Query: 556 LTLFNVTRNDARAYVCGI----QNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANL 611 + + + +D Y C + +++ VTL V TP IS D + Sbjct: 67 IVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSIS--DFEIPTSNIR 124 Query: 612 NLSCHSASN-PSPQYSWRING 631 + C ++ P P SW NG Sbjct: 125 RIICSTSGGFPEPHLSWLENG 145 Score = 43.4 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 24/140 (17%), Positives = 45/140 (32%), Gaps = 21/140 (15%) Query: 336 EDEDAVALTC----EPEIQNTTYLWWVNNQ--------------SLPVSPRLQLSNDNRT 377 E ++ L+C E T ++W + + + +N + Sbjct: 7 EVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLS 66 Query: 378 LTLLSVTRNDVGPYECGIQNKLSVDHSDP--VILNVLYGPDDPTISPSYTYYRPGVNLSL 435 + +L++ +D G YEC + + + D PT S S + Sbjct: 67 IVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRI 126 Query: 436 SCHAASN-PPAQYSWLIDGN 454 C + P SWL +G Sbjct: 127 ICSTSGGFPEPHLSWLENGE 146 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 26/151 (17%), Positives = 49/151 (32%), Gaps = 14/151 (9%) Query: 399 LSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSC-HAASNPPAQYSWLIDGNIQQ 457 ++ + + L+ + ++ + Y++ + L+ N +Y + I Sbjct: 4 VTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEY---KNRTIFD 60 Query: 458 HTQEL--FISNITEKNSGLYTCQA---NNSASGHSRTTVKTITVSAELPKPSISSNNSKP 512 T L I + + G Y C A T++V A+ P PSIS Sbjct: 61 ITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSIS---DFE 117 Query: 513 VEDKDAVAFTCEPEAQNTTY--LWWVNGQSL 541 + + C W NG+ L Sbjct: 118 IPTSNIRRIICSTSGGFPEPHLSWLENGEEL 148 Score = 38.8 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 17/99 (17%), Positives = 35/99 (35%), Gaps = 7/99 (7%) Query: 283 ELFIPNITVNNSGSYTCQAHNSDTGLNRTT---VTTITVYAEPPKPFITSNNSNPVEDED 339 + I + ++ G+Y C + + T++V A+ P P I+ + + Sbjct: 66 SIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSIS---DFEIPTSN 122 Query: 340 AVALTCEPEIQ-NTTYLWWVNNQSLPVSPRLQLSNDNRT 377 + C +L W+ N + +S D T Sbjct: 123 IRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPET 161 Score = 34.1 bits (76), Expect = 0.18, Method: Composition-based stats. Identities = 13/46 (28%), Positives = 22/46 (47%), Gaps = 3/46 (6%) Query: 642 IAKITPNNNGTYACFV---SNLATGRNNSIVKSITVSASGTSPGLS 684 I + P++ GTY C V A R + +++V A +P +S Sbjct: 69 ILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSIS 114 >1KOA-A nrPDB Length = 491 Score = 52.6 bits (124), Expect = 6e-07, Method: Composition-based stats. Identities = 17/94 (18%), Positives = 31/94 (32%), Gaps = 11/94 (11%) Query: 418 PTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQ-----------HTQELFISN 466 + P T G + + C ++ P +W D + + L I+ Sbjct: 379 FIVKPYGTEVGEGQSANFYCRVIASSPPVVTWHKDDRELKQSVKYMKRYNGNDYGLTINR 438 Query: 467 ITEKNSGLYTCQANNSASGHSRTTVKTITVSAEL 500 + + G YT +A NS +T +E Sbjct: 439 VKGDDKGEYTVRAKNSYGTKEEIVFLNVTRHSEP 472 Score = 50.3 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 19/107 (17%), Positives = 30/107 (28%), Gaps = 4/107 (3%) Query: 497 SAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRT- 555 +E I V + + F C A + + W + N Sbjct: 372 RSEAQPRFIVKPYGTEVGEGQSANFYCRVIASSPPVVTWHKDDRELKQSVKYMKRYNGND 431 Query: 556 --LTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISP 600 LT+ V +D Y +NS V L+V + P Sbjct: 432 YGLTINRVKGDDKGEYTVRAKNSYGTKEEI-VFLNVTRHSEPLKFEP 477 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 19/107 (17%), Positives = 29/107 (27%), Gaps = 4/107 (3%) Query: 142 PELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRT-- 199 E I V + + F C + W + + N Sbjct: 373 SEAQPRFIVKPYGTEVGEGQSANFYCRVIASSPPVVTWHKDDRELKQSVKYMKRYNGNDY 432 Query: 200 -LTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPL 245 LT+ V +D Y +N + V LNV + PL Sbjct: 433 GLTINRVKGDDKGEYTVRAKNSYGTKEEI-VFLNVTRHSEPLKFEPL 478 Score = 49.2 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 19/95 (20%), Positives = 35/95 (36%), Gaps = 11/95 (11%) Query: 242 ISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNG-----------TFQQSTQELFIPNIT 290 + P T G++ N C ++ P +W + + + L I + Sbjct: 381 VKPYGTEVGEGQSANFYCRVIASSPPVVTWHKDDRELKQSVKYMKRYNGNDYGLTINRVK 440 Query: 291 VNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKP 325 ++ G YT +A NS +T ++EP K Sbjct: 441 GDDKGEYTVRAKNSYGTKEEIVFLNVTRHSEPLKF 475 Score = 44.5 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 13/95 (13%), Positives = 31/95 (32%), Gaps = 11/95 (11%) Query: 597 IISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQV-----------LFIAKI 645 I+ P + G + N C ++ P +W + + + L I ++ Sbjct: 380 IVKPYGTEVGEGQSANFYCRVIASSPPVVTWHKDDRELKQSVKYMKRYNGNDYGLTINRV 439 Query: 646 TPNNNGTYACFVSNLATGRNNSIVKSITVSASGTS 680 ++ G Y N + + ++T + Sbjct: 440 KGDDKGEYTVRAKNSYGTKEEIVFLNVTRHSEPLK 474 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 19/114 (16%), Positives = 34/114 (29%), Gaps = 4/114 (3%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNN--QSLPVSPRLQLSNDNRT-LTLLS 382 FI V + + C + + W + + ++ N N LT+ Sbjct: 379 FIVKPYGTEVGEGQSANFYCRVIASSPPVVTWHKDDRELKQSVKYMKRYNGNDYGLTINR 438 Query: 383 VTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLS 436 V +D G Y +N + V LNV + P + + Sbjct: 439 VKGDDKGEYTVRAKNSYGTK-EEIVFLNVTRHSEPLKFEPLEPMKKAPSPPRVE 491 >1CFS-A nrPDB Length = 214 Score = 51.9 bits (122), Expect = 9e-07, Method: Composition-based stats. Identities = 36/201 (17%), Positives = 69/201 (34%), Gaps = 39/201 (19%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS-------LPVSPRLQLSNDNRT- 377 S +S + V +TC+ ++L W + + + RL + +R Sbjct: 4 MTQSPSSMYTSLGERVTITCKASQDINSFLTWFLQKPGKSPKTLIYRANRLMIGVPSRFS 63 Query: 378 ---------LTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYTY 426 LT+ S+ D+G Y C + + L++ PT+S P + Sbjct: 64 GSGSGQTYSLTISSLEYEDMGIYYCLQYDDFPLTFGAGTKLDLKRADAAPTVSIFPPSSE 123 Query: 427 YRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFISN 466 S+ C + P + + W IDG+ +Q+ + L ++ Sbjct: 124 QLTSGGASVVCFLNNFYPKEINVKWKIDGSERQNGVLDSWTEQDSKDSTYSMSSTLTLTK 183 Query: 467 ITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 184 DEYERHNSYTCEATHKTSTSP 204 Score = 45.7 bits (106), Expect = 7e-05, Method: Composition-based stats. Identities = 33/203 (16%), Positives = 65/203 (32%), Gaps = 41/203 (20%) Query: 147 PSISSNNSKPVEDKDAVAFTCEP--------------ETQDATYLWWVNNQSLPVSPRLQ 192 S +S + V TC+ + L + N+ + P Sbjct: 3 KMTQSPSSMYTSLGERVTITCKASQDINSFLTWFLQKPGKSPKTLIYRANRLMIGVPSRF 62 Query: 193 LSNGNR---TLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLN 246 +G+ +LT+ ++ D Y C + L++ APT+S P + Sbjct: 63 SGSGSGQTYSLTISSLEYEDMGIYYCLQYDDFPLTFGAGTKLDLKRADAAPTVSIFPPSS 122 Query: 247 TSYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFI 286 SG ++ C + P + W ++G+ +Q+ + L + Sbjct: 123 EQLTSG-GASVVCFLNNFYPKEINVKWKIDGSERQNGVLDSWTEQDSKDSTYSMSSTLTL 181 Query: 287 PNITVNNSGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 182 TKDEYERHNSYTCEATHKTSTSP 204 Score = 42.6 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 30/198 (15%), Positives = 61/198 (30%), Gaps = 39/198 (19%) Query: 506 SSNNSKPVEDKDAVAFTCEP--------------EAQNTTYLWWVNGQ---SLPVSPRLQ 548 S +S + V TC+ ++ L + + +P Sbjct: 6 QSPSSMYTSLGERVTITCKASQDINSFLTWFLQKPGKSPKTLIYRANRLMIGVPSRFSGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSYL 606 S +LT+ ++ D Y C + LD+ P +S PP S L Sbjct: 66 GSGQTYSLTISSLEYEDMGIYYCLQYDDFPLTFGAGTKLDLKRADAAPTVSIFPPSSEQL 125 Query: 607 SGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKIT 646 + ++ C + + + W+I+G +Q+ L + K Sbjct: 126 TSGGASVVCFLNNFYPKEINVKWKIDGSERQNGVLDSWTEQDSKDSTYSMSSTLTLTKDE 185 Query: 647 PNNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 YERHNSYTCEATHKTSTS 203 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 33/198 (16%), Positives = 62/198 (31%), Gaps = 39/198 (19%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQYSWL-------------------------IDG 453 T SPS Y G ++++C A+ + + +W G Sbjct: 5 TQSPSSMYTSLGERVTITCKASQDINSFLTWFLQKPGKSPKTLIYRANRLMIGVPSRFSG 64 Query: 454 NIQQHTQELFISNITEKNSGLYTC-QANNSASGHSRTTVKTITVSAELPKPSISSNNSKP 512 + T L IS++ ++ G+Y C Q ++ T + + P SI +S+ Sbjct: 65 SGSGQTYSLTISSLEYEDMGIYYCLQYDDFPLTFGAGTKLDLKRADAAPTVSIFPPSSEQ 124 Query: 513 VEDKDAVAFTCEPEAQNTT---YLWWVNGQS---------LPVSPRLQLSNGNRTLTLFN 560 + + C W ++G + + + TLTL Sbjct: 125 LTSG-GASVVCFLNNFYPKEINVKWKIDGSERQNGVLDSWTEQDSKDSTYSMSSTLTLTK 183 Query: 561 VTRNDARAYVCGIQNSVS 578 +Y C + S Sbjct: 184 DEYERHNSYTCEATHKTS 201 >3WO4-B nrPDB Length = 312 Score = 51.5 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 45/302 (14%), Positives = 93/302 (30%), Gaps = 42/302 (13%) Query: 146 KPSISSNNSKPVEDKDAVAF----TCEPETQDATYLWWVN----NQSLPVSPRL--QLSN 195 S +S V + + + T W + + ++PR +++ Sbjct: 2 PESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSSGSQEHVELNPRSSSRIAL 61 Query: 196 GNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTS---YRSG 252 + L + V NDT SY + +N + LNV+ + + Sbjct: 62 HDCVLEFWPVELNDTGSYFFQMKNY-----TQKWKLNVIRRNKHSCFTERQVTSKIVEVK 116 Query: 253 ENLNLSCH-----AASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTG 307 + ++C N + Y + + N + G Y+C G Sbjct: 117 KFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQGYYSCVHFLHHNG 176 Query: 308 L--NRTTVTTITVYAE--PPKPFITSNNSN--PVEDEDAVALTCEPEIQNTTYLWWV--- 358 N T IT+ + P + N VE V L C + ++W+ Sbjct: 177 KLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSALLNEEDVIYWMFGE 236 Query: 359 NNQSLP---VSPRLQLSNDNRT------LTLLSVTRNDV-GPYECGIQNKLSVDHSDPVI 408 N S P +++ L + ++ +++ Y C + + D ++ Sbjct: 237 ENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTVASTGGTDTKSFIL 296 Query: 409 LN 410 + Sbjct: 297 VR 298 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 48/248 (19%), Positives = 78/248 (31%), Gaps = 38/248 (15%) Query: 453 GNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKP 512 I H L + ++G Y +++ + + + SK Sbjct: 57 SRIALHDCVLEFWPVELNDTGSYF----FQMKNYTQKWKLNVIRRNKHSCFTERQVTSKI 112 Query: 513 VEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLF-NVTRNDARAYVC 571 VE K TCE N+ Y VN SL + + L N+ T+ N D Y C Sbjct: 113 VEVKKFFQITCE----NSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQGYYSC 168 Query: 572 GI---QNSVSANRSDPVTLDVLYGPD---TPIISPPDSSYLS--GANLNLSCHSASNPSP 623 N N + + ++ ++ P + G N+ L+C + N Sbjct: 169 VHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSALLNEED 228 Query: 624 QYSWRI---NG-IPQQH----------------TQVLFIAKITPNNNGT-YACFVSNLAT 662 W NG P H ++VL I I +N Y C V++ Sbjct: 229 VIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTVASTGG 288 Query: 663 GRNNSIVK 670 S + Sbjct: 289 TDTKSFIL 296 Score = 48.8 bits (114), Expect = 7e-06, Method: Composition-based stats. Identities = 58/304 (19%), Positives = 99/304 (32%), Gaps = 61/304 (20%) Query: 236 GPDAPTISPLNTSYRSGENLNL---SCH-AASNPPAQYSWFVNGTFQQSTQ--------- 282 GP++ T P + + GE L SC A SW+ + Q+ + Sbjct: 1 GPESCTSRP-HITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSSGSQEHVELNPRSSSRI 59 Query: 283 -----ELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPK--PFITSNNSNPV 335 L + +N++GSY N T + V S V Sbjct: 60 ALHDCVLEFWPVELNDTGSY------FFQMKNYTQKWKLNVIRRNKHSCFTERQVTSKIV 113 Query: 336 EDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLL-SVTRNDVGPYECG 394 E + +TCE N+ Y VN+ SL + + L +N+ T+ + D G Y C Sbjct: 114 EVKKFFQITCE----NSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQGYYSCV 169 Query: 395 I---QNKLSVDHSDPVILNVLYGPD---DPTISP--SYTYYRPGVNLSLSCHAASNPPAQ 446 N + + + ++ + P ++ G N+ L+C A N Sbjct: 170 HFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSALLNEEDV 229 Query: 447 YSWLIDGNIQQH--------------------TQELFISNITEKNSG-LYTCQANNSASG 485 W+ ++ L I NI E N LY C ++ Sbjct: 230 IYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTVASTGGT 289 Query: 486 HSRT 489 +++ Sbjct: 290 DTKS 293 >1MLC-A nrPDB Length = 214 Score = 51.1 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 42/203 (20%), Positives = 67/203 (33%), Gaps = 41/203 (20%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQL------------- 371 S + V D+V+L+C + L W +S SPRL + Sbjct: 3 ELTQSPATLSVTPGDSVSLSCRASQSISNNLHWYQQKSH-ESPRLLIKYVSQSSSGIPSR 61 Query: 372 -----SNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSY 424 S + TL++ SV D G Y C N L + PT+S P Sbjct: 62 FSGSGSGTDFTLSINSVETEDFGMYFCQQSNSWPRTFGGGTKLEIKRADAAPTVSIFPPS 121 Query: 425 TYYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFI 464 + S+ C + P + W IDG+ +Q+ + L + Sbjct: 122 SEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTL 181 Query: 465 SNITEKNSGLYTCQANNSASGHS 487 + + YTC+A + S Sbjct: 182 TKDEYERHNSYTCEATHKTSTSP 204 Score = 42.6 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 36/203 (17%), Positives = 64/203 (31%), Gaps = 41/203 (20%) Query: 147 PSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSP 189 S + V D+V+ +C + L W +S +P Sbjct: 3 ELTQSPATLSVTPGDSVSLSCRASQSISNNLHWYQQKSHESPRLLIKYVSQSSSGIPSRF 62 Query: 190 RLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLN 246 S + TL++ +V D Y C+ N L + APT+S P + Sbjct: 63 SGSGSGTDFTLSINSVETEDFGMYFCQQSNSWPRTFGGGTKLEIKRADAAPTVSIFPPSS 122 Query: 247 TSYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFI 286 SG ++ C + P W ++G+ +Q+ + L + Sbjct: 123 EQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTL 181 Query: 287 PNITVNNSGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 182 TKDEYERHNSYTCEATHKTSTSP 204 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 39/204 (19%), Positives = 58/204 (28%), Gaps = 49/204 (24%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP S G++++LSC A+ + W+ G Sbjct: 5 TQSPATLSVTPGDSVSLSCRASQSISNNLHWYQQKSHESPRLLIKYVSQSSSGIPSRFSG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQAHNS-DTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 + + L I ++ + G Y CQ NS T I P I +S Sbjct: 65 SGSGTDFTLSINSVETEDFGMYFCQQSNSWPRTFGGGTKLEIKRADAAPTVSIFPPSSEQ 124 Query: 335 VEDEDAVALTC-----------------EPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRT 377 + ++ C E QN L +Q S + T Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGV-LNSWTDQDSKDSTYSM----SST 178 Query: 378 LTLLSVTRNDVGPYECGIQNKLSV 401 LTL Y C +K S Sbjct: 179 LTLTKDEYERHNSYTCEATHKTST 202 Score = 38.0 bits (86), Expect = 0.014, Method: Composition-based stats. Identities = 37/203 (18%), Positives = 61/203 (30%), Gaps = 15/203 (7%) Query: 34 AKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGP 93 +LT +V G V L WY+ + + R +I YV + P Sbjct: 2 IELTQSPATLSVTPGDSVSLSCRASQSISNNLHWYQQKSHESPRLLIKYVSQSSSGIPS- 60 Query: 94 AYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSIS--- 150 +SG + +L I ++ D G Y S + + P++S Sbjct: 61 RFSGSGSGT-DFTLSINSVETEDFGMYFCQQSNSWPRTFGGGTKLEIKRADAAPTVSIFP 119 Query: 151 -SNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS---------LPVSPRLQLSNGNRTL 200 S+ V F +D W ++ + + + TL Sbjct: 120 PSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTL 179 Query: 201 TLFNVTRNDTASYKCETQNPVSA 223 TL SY CE + S Sbjct: 180 TLTKDEYERHNSYTCEATHKTST 202 Score = 30.3 bits (66), Expect = 3.1, Method: Composition-based stats. Identities = 19/87 (21%), Positives = 30/87 (34%), Gaps = 25/87 (28%) Query: 599 SPPDSSYLSGANLNLSCHSASNPSPQYSWRI------------------NGIPQQHTQ-- 638 SP S G +++LSC ++ + S W +GIP + + Sbjct: 7 SPATLSVTPGDSVSLSCRASQSISNNLHWYQQKSHESPRLLIKYVSQSSSGIPSRFSGSG 66 Query: 639 -----VLFIAKITPNNNGTYACFVSNL 660 L I + + G Y C SN Sbjct: 67 SGTDFTLSINSVETEDFGMYFCQQSNS 93 >1QGC-4 nrPDB Length = 218 Score = 50.7 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 34/202 (16%), Positives = 57/202 (28%), Gaps = 43/202 (21%) Query: 506 SSNNSKPVEDKDAVAFTCEP------------------EAQNTTYLWWVN---GQSLPVS 544 S S V +C Q L + +P Sbjct: 6 QSPASLAVSLGQRATISCRASESVDSSGHSFMHWYQQKPGQPPKLLIYRASNLESGIPDR 65 Query: 545 PRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPD 602 S + TLT+ V +D Y C N V LD+ P +S PP Sbjct: 66 FSGSGSRTDFTLTIDPVEADDVATYYCQQSNEVPLTFGAGTKLDLKRADAAPTVSIFPPS 125 Query: 603 SSYLSGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFI 642 S L+ ++ C + + W+I+G +Q+ L + Sbjct: 126 SEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTL 185 Query: 643 AKITPNNNGTYACFVSNLATGR 664 K + +Y C ++ + Sbjct: 186 TKDEYERHNSYTCEATHKTSTS 207 Score = 44.5 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 36/206 (17%), Positives = 63/206 (30%), Gaps = 43/206 (20%) Query: 325 PFITSNNSNPVEDEDAVALTCEP------------------EIQNTTYLWWVNNQSLPVS 366 S S V ++C Q L + + Sbjct: 3 VLTQSPASLAVSLGQRATISCRASESVDSSGHSFMHWYQQKPGQPPKLLIYRASNLESGI 62 Query: 367 PRLQLSNDNRT---LTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS-- 421 P + +RT LT+ V +DV Y C N++ + L++ PT+S Sbjct: 63 PDRFSGSGSRTDFTLTIDPVEADDVATYYCQQSNEVPLTFGAGTKLDLKRADAAPTVSIF 122 Query: 422 PSYTYYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQE 461 P + S+ C + P + W IDG+ +Q+ + Sbjct: 123 PPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSST 182 Query: 462 LFISNITEKNSGLYTCQANNSASGHS 487 L ++ + YTC+A + S Sbjct: 183 LTLTKDEYERHNSYTCEATHKTSTSP 208 Score = 44.5 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 34/166 (20%), Positives = 59/166 (35%), Gaps = 27/166 (16%) Query: 170 ETQDATYLWWVNNQSLPVSPRLQLSNGNRT---LTLFNVTRNDTASYKCETQNPVSARRS 226 Q L + + P +G+RT LT+ V +D A+Y C+ N V Sbjct: 44 PGQPPKLLIYRASNLESGIPDRFSGSGSRTDFTLTIDPVEADDVATYYCQQSNEVPLTFG 103 Query: 227 DSVILNVLYGPDAPTIS---PLNTSYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS- 280 L++ APT+S P + SG ++ C + P W ++G+ +Q+ Sbjct: 104 AGTKLDLKRADAAPTVSIFPPSSEQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNG 162 Query: 281 -----------------TQELFIPNITVNNSGSYTCQAHNSDTGLN 309 + L + SYTC+A + + Sbjct: 163 VLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSP 208 Score = 42.6 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 28/165 (16%), Positives = 49/165 (29%), Gaps = 14/165 (8%) Query: 427 YRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSAS-G 485 +PG L + ASN + G+ + L I + + Y CQ +N Sbjct: 42 QKPGQPPKLLIYRASNLESGIPDRFSGSGSRTDFTLTIDPVEADDVATYYCQQSNEVPLT 101 Query: 486 HSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTT---YLWWVNGQSLP 542 T + + P SI +S+ + + C W ++G Sbjct: 102 FGAGTKLDLKRADAAPTVSIFPPSSEQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQ 160 Query: 543 V---------SPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVS 578 + + + TLTL +Y C + S Sbjct: 161 NGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTS 205 Score = 34.5 bits (77), Expect = 0.18, Method: Composition-based stats. Identities = 35/208 (16%), Positives = 57/208 (27%), Gaps = 53/208 (25%) Query: 241 TISPLNTSYRSGENLNLSCHAA------------------SNPPAQYSW----------- 271 T SP + + G+ +SC A+ PP + Sbjct: 5 TQSPASLAVSLGQRATISCRASESVDSSGHSFMHWYQQKPGQPPKLLIYRASNLESGIPD 64 Query: 272 FVNGTFQQSTQELFIPNITVNNSGSYTCQAHN-SDTGLNRTTVTTITVYAEPPKPFITSN 330 +G+ ++ L I + ++ +Y CQ N T + P I Sbjct: 65 RFSGSGSRTDFTLTIDPVEADDVATYYCQQSNEVPLTFGAGTKLDLKRADAAPTVSIFPP 124 Query: 331 NSNPVEDEDAVALTC-----------------EPEIQNTTYLWWVNNQSLPVSPRLQLSN 373 +S + ++ C E QN L +Q S Sbjct: 125 SSEQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGV-LNSWTDQDSKDSTYSM--- 179 Query: 374 DNRTLTLLSVTRNDVGPYECGIQNKLSV 401 + TLTL Y C +K S Sbjct: 180 -SSTLTLTKDEYERHNSYTCEATHKTST 206 Score = 30.7 bits (67), Expect = 2.2, Method: Composition-based stats. Identities = 29/207 (14%), Positives = 62/207 (29%), Gaps = 19/207 (9%) Query: 33 TAKLTIESTPFNVAEGKEVLLLVH---NLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQA 89 + S ++ + + + H F + WY+ ++ +++ Y ++ Sbjct: 3 VLTQSPASLAVSLGQRATISCRASESVDSSGHSFMH-WYQ-QKPGQPPKLLIYRASNLES 60 Query: 90 TPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSI 149 +SG + +L I + +D Y + A + + P++ Sbjct: 61 GIPDRFSGSGSRT-DFTLTIDPVEADDVATYYCQQSNEVPLTFGAGTKLDLKRADAAPTV 119 Query: 150 S----SNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS---------LPVSPRLQLSNG 196 S S+ V F +D W ++ + + Sbjct: 120 SIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSM 179 Query: 197 NRTLTLFNVTRNDTASYKCETQNPVSA 223 + TLTL SY CE + S Sbjct: 180 SSTLTLTKDEYERHNSYTCEATHKTST 206 >3UTO-A nrPDB Length = 573 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 16/89 (17%), Positives = 29/89 (32%), Gaps = 11/89 (12%) Query: 418 PTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQ-----------HTQELFISN 466 + P T G + + C ++ P +W D + + L I+ Sbjct: 485 FIVKPYGTEVGEGQSANFYCRVIASSPPVVTWHKDDRELKQSVKYMKRYNGNDYGLTINR 544 Query: 467 ITEKNSGLYTCQANNSASGHSRTTVKTIT 495 + + G YT +A NS +T Sbjct: 545 VKGDDKGEYTVRAKNSYGTKEEIVFLNVT 573 Score = 49.6 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 15/89 (16%), Positives = 24/89 (26%), Gaps = 3/89 (3%) Query: 497 SAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRT- 555 +E I V + + F C A + + W + N Sbjct: 478 RSEAQPRFIVKPYGTEVGEGQSANFYCRVIASSPPVVTWHKDDRELKQSVKYMKRYNGND 537 Query: 556 --LTLFNVTRNDARAYVCGIQNSVSANRS 582 LT+ V +D Y +NS Sbjct: 538 YGLTINRVKGDDKGEYTVRAKNSYGTKEE 566 Score = 46.5 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 16/87 (18%), Positives = 30/87 (34%), Gaps = 11/87 (12%) Query: 242 ISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNG-----------TFQQSTQELFIPNIT 290 + P T G++ N C ++ P +W + + + L I + Sbjct: 487 VKPYGTEVGEGQSANFYCRVIASSPPVVTWHKDDRELKQSVKYMKRYNGNDYGLTINRVK 546 Query: 291 VNNSGSYTCQAHNSDTGLNRTTVTTIT 317 ++ G YT +A NS +T Sbjct: 547 GDDKGEYTVRAKNSYGTKEEIVFLNVT 573 Score = 46.1 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 17/96 (17%), Positives = 26/96 (27%), Gaps = 4/96 (4%) Query: 142 PELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRT-- 199 E I V + + F C + W + + N Sbjct: 479 SEAQPRFIVKPYGTEVGEGQSANFYCRVIASSPPVVTWHKDDRELKQSVKYMKRYNGNDY 538 Query: 200 -LTLFNVTRNDTASYKCETQNPVSARRSDSVILNVL 234 LT+ V +D Y +N + V LNV Sbjct: 539 GLTINRVKGDDKGEYTVRAKNSYGTKEEI-VFLNVT 573 Score = 44.2 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 13/88 (14%), Positives = 30/88 (34%), Gaps = 11/88 (12%) Query: 597 IISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQV-----------LFIAKI 645 I+ P + G + N C ++ P +W + + + L I ++ Sbjct: 486 IVKPYGTEVGEGQSANFYCRVIASSPPVVTWHKDDRELKQSVKYMKRYNGNDYGLTINRV 545 Query: 646 TPNNNGTYACFVSNLATGRNNSIVKSIT 673 ++ G Y N + + ++T Sbjct: 546 KGDDKGEYTVRAKNSYGTKEEIVFLNVT 573 Score = 39.2 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 18/90 (20%), Positives = 30/90 (33%), Gaps = 4/90 (4%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNN--QSLPVSPRLQLSNDNRT-LTLLS 382 FI V + + C + + W + + ++ N N LT+ Sbjct: 485 FIVKPYGTEVGEGQSANFYCRVIASSPPVVTWHKDDRELKQSVKYMKRYNGNDYGLTINR 544 Query: 383 VTRNDVGPYECGIQNKLSVDHSDPVILNVL 412 V +D G Y +N + V LNV Sbjct: 545 VKGDDKGEYTVRAKNSYGTK-EEIVFLNVT 573 >1C12-A nrPDB Length = 214 Score = 50.3 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 36/202 (17%), Positives = 63/202 (31%), Gaps = 39/202 (19%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS---------------LPVSPRL 369 S +S V D V++TC ++ + W+ + V R Sbjct: 3 ELTQSPSSMSVSLGDTVSITCHASQGISSNIGWLQQKPGKSFKGLIYHGTNLEDGVPSRF 62 Query: 370 QLSNDNR--TLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYT 425 S +LT+ S+ D Y C + L + PT+S P + Sbjct: 63 SGSGSGADYSLTISSLESEDFADYYCVQYVQFPFTFGSGTKLEIKRADAAPTVSIFPPSS 122 Query: 426 YYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFIS 465 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 123 EQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLT 182 Query: 466 NITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 183 KDEYERHNSYTCEATHKTSTSP 204 Score = 43.4 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 35/203 (17%), Positives = 64/203 (31%), Gaps = 41/203 (20%) Query: 147 PSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSP 189 S +S V D V+ TC ++ + W+ + +P Sbjct: 3 ELTQSPSSMSVSLGDTVSITCHASQGISSNIGWLQQKPGKSFKGLIYHGTNLEDGVPSRF 62 Query: 190 RLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLN 246 S + +LT+ ++ D A Y C L + APT+S P + Sbjct: 63 SGSGSGADYSLTISSLESEDFADYYCVQYVQFPFTFGSGTKLEIKRADAAPTVSIFPPSS 122 Query: 247 TSYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFI 286 SG ++ C + P W ++G+ +Q+ + L + Sbjct: 123 EQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTL 181 Query: 287 PNITVNNSGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 182 TKDEYERHNSYTCEATHKTSTSP 204 Score = 43.0 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 31/198 (15%), Positives = 60/198 (30%), Gaps = 39/198 (19%) Query: 506 SSNNSKPVEDKDAVAFTCEP--------------EAQNTTYLWWVN---GQSLPVSPRLQ 548 S +S V D V+ TC ++ L + +P Sbjct: 6 QSPSSMSVSLGDTVSITCHASQGISSNIGWLQQKPGKSFKGLIYHGTNLEDGVPSRFSGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSYL 606 S + +LT+ ++ D Y C L++ P +S PP S L Sbjct: 66 GSGADYSLTISSLESEDFADYYCVQYVQFPFTFGSGTKLEIKRADAAPTVSIFPPSSEQL 125 Query: 607 SGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKIT 646 + ++ C + + W+I+G +Q+ L + K Sbjct: 126 TSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDE 185 Query: 647 PNNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 YERHNSYTCEATHKTSTS 203 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 35/204 (17%), Positives = 55/204 (26%), Gaps = 49/204 (24%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP + S G+ ++++CHA+ + W G Sbjct: 5 TQSPSSMSVSLGDTVSITCHASQGISSNIGWLQQKPGKSFKGLIYHGTNLEDGVPSRFSG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTC-QAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 + + L I ++ + Y C Q T I P I +S Sbjct: 65 SGSGADYSLTISSLESEDFADYYCVQYVQFPFTFGSGTKLEIKRADAAPTVSIFPPSSEQ 124 Query: 335 VEDEDAVALTC-----------------EPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRT 377 + ++ C E QN L +Q S + T Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGV-LNSWTDQDSKDSTYSM----SST 178 Query: 378 LTLLSVTRNDVGPYECGIQNKLSV 401 LTL Y C +K S Sbjct: 179 LTLTKDEYERHNSYTCEATHKTST 202 >4PBV-A nrPDB Length = 268 Score = 49.9 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 25/95 (26%), Positives = 39/95 (41%), Gaps = 15/95 (15%) Query: 416 DDPTISPSYTYY--RPGVNLSLSCHAASNPPAQYSW----LIDGNIQQ--------HTQE 461 D P IS S+ R G N ++C + +P W L N Q H + Sbjct: 165 DLPEISVSHVNLTVREGENAVITCQGSGSPLPDVDWTVADLHSINTHQTNLQWTNVHAIQ 224 Query: 462 LFISNITEKNSG-LYTCQANNSASGHSRTTVKTIT 495 L + N+T +++G L TC A N + + T+ Sbjct: 225 LTLVNVTSEDNGFLLTCIAENVVGMSQASVLLTVY 259 Score = 48.0 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 21/99 (21%), Positives = 40/99 (40%), Gaps = 14/99 (14%) Query: 231 LNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFV-----------NGTFQQ 279 + P+ ++S +N + R GEN ++C + +P W V N + Sbjct: 161 ITQCDLPE-ISVSHVNLTVREGENAVITCQGSGSPLPDVDWTVADLHSINTHQTNLQWTN 219 Query: 280 -STQELFIPNITVNNSG-SYTCQAHNSDTGLNRTTVTTI 316 +L + N+T ++G TC A N + + T+ Sbjct: 220 VHAIQLTLVNVTSEDNGFLLTCIAENVVGMSQASVLLTV 258 Score = 45.3 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 22/97 (22%), Positives = 33/97 (34%), Gaps = 7/97 (7%) Query: 499 ELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRT--- 555 +LP+ S+S N V + + TC+ + W ++ Sbjct: 165 DLPEISVSHVN-LTVREGENAVITCQGSGSPLPDVDWTVADLHSINTHQTNLQWTNVHAI 223 Query: 556 -LTLFNVTRNDARA-YVCGIQNSVSANRSDPVTLDVL 590 LTL NVT D C +N V + V L V Sbjct: 224 QLTLVNVTSEDNGFLLTCIAENVVGMS-QASVLLTVY 259 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 16/99 (16%), Positives = 36/99 (36%), Gaps = 14/99 (14%) Query: 587 LDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQ-------- 638 + P+ +S + + G N ++C + +P P W + + +T Sbjct: 161 ITQCDLPEIS-VSHVNLTVREGENAVITCQGSGSPLPDVDWTVADLHSINTHQTNLQWTN 219 Query: 639 ----VLFIAKITPNNNGT-YACFVSNLATGRNNSIVKSI 672 L + +T +NG C N+ S++ ++ Sbjct: 220 VHAIQLTLVNVTSEDNGFLLTCIAENVVGMSQASVLLTV 258 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 30/77 (38%), Gaps = 5/77 (6%) Query: 329 SNNSNPVEDEDAVALTCEPEIQNTTYLWWV----NNQSLPVSPRLQLSNDNRTLTLLSVT 384 S+ + V + + +TC+ + W ++ + + + LTL++VT Sbjct: 172 SHVNLTVREGENAVITCQGSGSPLPDVDWTVADLHSINTHQTNLQWTNVHAIQLTLVNVT 231 Query: 385 RNDVGP-YECGIQNKLS 400 D G C +N + Sbjct: 232 SEDNGFLLTCIAENVVG 248 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 19/102 (18%), Positives = 34/102 (33%), Gaps = 6/102 (5%) Query: 137 QFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWW----VNNQSLPVSPRLQ 192 + S+ + V + + TC+ + W +++ + + Sbjct: 158 NMNITQCDLPEISVSHVNLTVREGENAVITCQGSGSPLPDVDWTVADLHSINTHQTNLQW 217 Query: 193 LSNGNRTLTLFNVTRNDTAS-YKCETQNPVSARRSDSVILNV 233 + LTL NVT D C +N V SV+L V Sbjct: 218 TNVHAIQLTLVNVTSEDNGFLLTCIAENVVGM-SQASVLLTV 258 >4PBW-B nrPDB Length = 283 Score = 49.9 bits (117), Expect = 4e-06, Method: Composition-based stats. Identities = 25/95 (26%), Positives = 39/95 (41%), Gaps = 15/95 (15%) Query: 416 DDPTISPSYTYY--RPGVNLSLSCHAASNPPAQYSW----LIDGNIQQ--------HTQE 461 D P IS S+ R G N ++C + +P W L N Q H + Sbjct: 180 DLPEISVSHVNLTVREGENAVITCQGSGSPLPDVDWTVADLHSINTHQTNLQWTNVHAIQ 239 Query: 462 LFISNITEKNSG-LYTCQANNSASGHSRTTVKTIT 495 L + N+T +++G L TC A N + + T+ Sbjct: 240 LTLVNVTSEDNGFLLTCIAENVVGMSQASVLLTVY 274 Score = 47.6 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 21/99 (21%), Positives = 40/99 (40%), Gaps = 14/99 (14%) Query: 231 LNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFV-----------NGTFQQ 279 + P+ ++S +N + R GEN ++C + +P W V N + Sbjct: 176 ITQCDLPE-ISVSHVNLTVREGENAVITCQGSGSPLPDVDWTVADLHSINTHQTNLQWTN 234 Query: 280 -STQELFIPNITVNNSG-SYTCQAHNSDTGLNRTTVTTI 316 +L + N+T ++G TC A N + + T+ Sbjct: 235 VHAIQLTLVNVTSEDNGFLLTCIAENVVGMSQASVLLTV 273 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 22/97 (22%), Positives = 33/97 (34%), Gaps = 7/97 (7%) Query: 499 ELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRT--- 555 +LP+ S+S N V + + TC+ + W ++ Sbjct: 180 DLPEISVSHVN-LTVREGENAVITCQGSGSPLPDVDWTVADLHSINTHQTNLQWTNVHAI 238 Query: 556 -LTLFNVTRNDARA-YVCGIQNSVSANRSDPVTLDVL 590 LTL NVT D C +N V + V L V Sbjct: 239 QLTLVNVTSEDNGFLLTCIAENVVGMS-QASVLLTVY 274 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 16/99 (16%), Positives = 36/99 (36%), Gaps = 14/99 (14%) Query: 587 LDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQ-------- 638 + P+ +S + + G N ++C + +P P W + + +T Sbjct: 176 ITQCDLPEIS-VSHVNLTVREGENAVITCQGSGSPLPDVDWTVADLHSINTHQTNLQWTN 234 Query: 639 ----VLFIAKITPNNNGT-YACFVSNLATGRNNSIVKSI 672 L + +T +NG C N+ S++ ++ Sbjct: 235 VHAIQLTLVNVTSEDNGFLLTCIAENVVGMSQASVLLTV 273 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 30/77 (38%), Gaps = 5/77 (6%) Query: 329 SNNSNPVEDEDAVALTCEPEIQNTTYLWWV----NNQSLPVSPRLQLSNDNRTLTLLSVT 384 S+ + V + + +TC+ + W ++ + + + LTL++VT Sbjct: 187 SHVNLTVREGENAVITCQGSGSPLPDVDWTVADLHSINTHQTNLQWTNVHAIQLTLVNVT 246 Query: 385 RNDVGP-YECGIQNKLS 400 D G C +N + Sbjct: 247 SEDNGFLLTCIAENVVG 263 Score = 39.9 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 19/102 (18%), Positives = 34/102 (33%), Gaps = 6/102 (5%) Query: 137 QFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWW----VNNQSLPVSPRLQ 192 + S+ + V + + TC+ + W +++ + + Sbjct: 173 NMNITQCDLPEISVSHVNLTVREGENAVITCQGSGSPLPDVDWTVADLHSINTHQTNLQW 232 Query: 193 LSNGNRTLTLFNVTRNDTAS-YKCETQNPVSARRSDSVILNV 233 + LTL NVT D C +N V SV+L V Sbjct: 233 TNVHAIQLTLVNVTSEDNGFLLTCIAENVVGM-SQASVLLTV 273 >1WEJ-L nrPDB Length = 214 Score = 49.2 bits (115), Expect = 7e-06, Method: Composition-based stats. Identities = 38/204 (18%), Positives = 59/204 (28%), Gaps = 49/204 (24%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP + S GE + ++C A+ N +W+ G Sbjct: 5 TQSPASLSASVGETVTITCRASGNIHNYLAWYQQKQGKSPQLLVYNAKTLADGVPSRFSG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQ-AHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 + + L I ++ + GSY CQ ++ T I P I +S Sbjct: 65 SGSGTQYSLKINSLQPEDFGSYYCQHFWSTPWTFGGGTKLEIKRADAAPTVSIFPPSSEQ 124 Query: 335 VEDEDAVALTC-----------------EPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRT 377 + ++ C E QN L +Q S + T Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGV-LNSWTDQDSKDSTYSM----SST 178 Query: 378 LTLLSVTRNDVGPYECGIQNKLSV 401 LTL Y C +K S Sbjct: 179 LTLTKDEYERHNSYTCEATHKTST 202 Score = 38.8 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 33/198 (16%), Positives = 59/198 (29%), Gaps = 39/198 (19%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQYSWLI------------------DGNIQQHT- 459 T SP+ G ++++C A+ N +W DG + + Sbjct: 5 TQSPASLSASVGETVTITCRASGNIHNYLAWYQQKQGKSPQLLVYNAKTLADGVPSRFSG 64 Query: 460 ------QELFISNITEKNSGLYTCQANNSAS-GHSRTTVKTITVSAELPKPSISSNNSKP 512 L I+++ ++ G Y CQ S T I + P SI +S+ Sbjct: 65 SGSGTQYSLKINSLQPEDFGSYYCQHFWSTPWTFGGGTKLEIKRADAAPTVSIFPPSSEQ 124 Query: 513 VEDKDAVAFTCEPEAQNTT---YLWWVNGQSLPV---------SPRLQLSNGNRTLTLFN 560 + + C W ++G + + + TLTL Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 183 Query: 561 VTRNDARAYVCGIQNSVS 578 +Y C + S Sbjct: 184 DEYERHNSYTCEATHKTS 201 Score = 38.8 bits (88), Expect = 0.009, Method: Composition-based stats. Identities = 34/201 (16%), Positives = 58/201 (28%), Gaps = 41/201 (20%) Query: 149 ISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRL 191 S S + V TC YL W + +P Sbjct: 5 TQSPASLSASVGETVTITCRASGNIHNYLAWYQQKQGKSPQLLVYNAKTLADGVPSRFSG 64 Query: 192 QLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTS 248 S +L + ++ D SY C+ L + APT+S P + Sbjct: 65 SGSGTQYSLKINSLQPEDFGSYYCQHFWSTPWTFGGGTKLEIKRADAAPTVSIFPPSSEQ 124 Query: 249 YRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFIPN 288 SG ++ C + P W ++G+ +Q+ + L + Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 183 Query: 289 ITVNNSGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 184 DEYERHNSYTCEATHKTSTSP 204 Score = 34.1 bits (76), Expect = 0.23, Method: Composition-based stats. Identities = 15/83 (18%), Positives = 25/83 (30%), Gaps = 25/83 (30%) Query: 599 SPPDSSYLSGANLNLSCHSASNPSPQYSW-------------------------RINGIP 633 SP S G + ++C ++ N +W R +G Sbjct: 7 SPASLSASVGETVTITCRASGNIHNYLAWYQQKQGKSPQLLVYNAKTLADGVPSRFSGSG 66 Query: 634 QQHTQVLFIAKITPNNNGTYACF 656 L I + P + G+Y C Sbjct: 67 SGTQYSLKINSLQPEDFGSYYCQ 89 >1KCU-L nrPDB Length = 214 Score = 49.2 bits (115), Expect = 7e-06, Method: Composition-based stats. Identities = 39/202 (19%), Positives = 63/202 (31%), Gaps = 39/202 (19%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNR-------- 376 S S + + V L+C+ TY+ W + L NR Sbjct: 3 VLTQSPKSMSMSVGEKVTLSCKASENVDTYVSWYQQRPEQPPALLIYGASNRYTGVPDRF 62 Query: 377 ---------TLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYT 425 TLT+ SV D+ Y CG + L + PT+S P + Sbjct: 63 TGSGSATDFTLTISSVQAEDLADYHCGQSYSYPLTFGGGTKLELKRADAAPTVSIFPPSS 122 Query: 426 YYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFIS 465 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 123 EQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVANSWTAQDSKDSTYSMSSTLTLT 182 Query: 466 NITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 183 KDEYERHNSYTCEATHKTSTSP 204 Score = 41.1 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 34/199 (17%), Positives = 57/199 (28%), Gaps = 39/199 (19%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP + S GE + LSC A+ N SW+ G Sbjct: 5 TQSPKSMSMSVGEKVTLSCKASENVDTYVSWYQQRPEQPPALLIYGASNRYTGVPDRFTG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTC-QAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 + + L I ++ + Y C Q+++ T + P I +S Sbjct: 65 SGSATDFTLTISSVQAEDLADYHCGQSYSYPLTFGGGTKLELKRADAAPTVSIFPPSSEQ 124 Query: 335 VEDEDAVALTCEPEI--QNTTYLWWVNNQS----------LPVSPRLQLSNDNRTLTLLS 382 + ++ C + W + S + + + TLTL Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVANSWTAQDSKDSTYSMSSTLTLTK 183 Query: 383 VTRNDVGPYECGIQNKLSV 401 Y C +K S Sbjct: 184 DEYERHNSYTCEATHKTST 202 Score = 39.9 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 35/201 (17%), Positives = 62/201 (30%), Gaps = 41/201 (20%) Query: 149 ISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-------LPVSPRLQL-------- 193 S S + + V +C+ TY+ W + + + Sbjct: 5 TQSPKSMSMSVGEKVTLSCKASENVDTYVSWYQQRPEQPPALLIYGASNRYTGVPDRFTG 64 Query: 194 --SNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTS 248 S + TLT+ +V D A Y C L + APT+S P + Sbjct: 65 SGSATDFTLTISSVQAEDLADYHCGQSYSYPLTFGGGTKLELKRADAAPTVSIFPPSSEQ 124 Query: 249 YRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFIPN 288 SG ++ C + P W ++G+ +Q+ + L + Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVANSWTAQDSKDSTYSMSSTLTLTK 183 Query: 289 ITVNNSGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 184 DEYERHNSYTCEATHKTSTSP 204 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 35/198 (17%), Positives = 62/198 (31%), Gaps = 39/198 (19%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTY-LWWVNGQSLPVS--------------PRLQLS 550 S S + + V +C+ TY W+ P + R S Sbjct: 6 QSPKSMSMSVGEKVTLSCKASENVDTYVSWYQQRPEQPPALLIYGASNRYTGVPDRFTGS 65 Query: 551 NG--NRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSYL 606 + TLT+ +V D Y CG S L++ P +S PP S L Sbjct: 66 GSATDFTLTISSVQAEDLADYHCGQSYSYPLTFGGGTKLELKRADAAPTVSIFPPSSEQL 125 Query: 607 SGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKIT 646 + ++ C + + W+I+G +Q+ L + K Sbjct: 126 TSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVANSWTAQDSKDSTYSMSSTLTLTKDE 185 Query: 647 PNNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 YERHNSYTCEATHKTSTS 203 >3F7V-B nrPDB Length = 212 Score = 48.4 bits (113), Expect = 9e-06, Method: Composition-based stats. Identities = 38/202 (18%), Positives = 65/202 (32%), Gaps = 41/202 (20%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQL-------------- 371 S V + V+ +C T + W ++ SPRL + Sbjct: 4 LTQSPAILSVSPGERVSFSCRASQSIGTDIHWYQQRTNG-SPRLLIKYASESISGIPSRF 62 Query: 372 ----SNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYT 425 S + TL++ SV D+ Y C N+ L + PT+S P + Sbjct: 63 SGSGSGTDFTLSINSVESEDIANYYCQQSNRWPFTFGSGTKLEIKRADAAPTVSIFPPSS 122 Query: 426 YYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFIS 465 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 123 EQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLT 182 Query: 466 NITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 183 KDEYERHNSYTCEATHKTSTSP 204 Score = 43.8 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 36/194 (18%), Positives = 65/194 (33%), Gaps = 41/194 (21%) Query: 156 PVEDKDAVAFTCEPETQDATYLWWVNN--------------QSLPVSPRLQLSNGNRT-- 199 V + V+F+C T + W +S+ P +G+ T Sbjct: 12 SVSPGERVSFSCRASQSIGTDIHWYQQRTNGSPRLLIKYASESISGIPSRFSGSGSGTDF 71 Query: 200 -LTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTSYRSGENL 255 L++ +V D A+Y C+ N L + APT+S P + SG Sbjct: 72 TLSINSVESEDIANYYCQQSNRWPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSG-GA 130 Query: 256 NLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFIPNITVNNSG 295 ++ C + P W ++G+ +Q+ + L + Sbjct: 131 SVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHN 190 Query: 296 SYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 191 SYTCEATHKTSTSP 204 Score = 41.1 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 34/198 (17%), Positives = 59/198 (29%), Gaps = 39/198 (19%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQYSWL------------------IDGNIQQHTQ 460 T SP+ PG +S SC A+ + W I G + + Sbjct: 5 TQSPAILSVSPGERVSFSCRASQSIGTDIHWYQQRTNGSPRLLIKYASESISGIPSRFSG 64 Query: 461 -------ELFISNITEKNSGLYTCQANNSASGHSRT-TVKTITVSAELPKPSISSNNSKP 512 L I+++ ++ Y CQ +N + T I + P SI +S+ Sbjct: 65 SGSGTDFTLSINSVESEDIANYYCQQSNRWPFTFGSGTKLEIKRADAAPTVSIFPPSSEQ 124 Query: 513 VEDKDAVAFTCEPEAQNTT---YLWWVNGQSLPV---------SPRLQLSNGNRTLTLFN 560 + + C W ++G + + + TLTL Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 183 Query: 561 VTRNDARAYVCGIQNSVS 578 +Y C + S Sbjct: 184 DEYERHNSYTCEATHKTS 201 >1IGY-A nrPDB Length = 213 Score = 48.4 bits (113), Expect = 9e-06, Method: Composition-based stats. Identities = 41/200 (20%), Positives = 67/200 (33%), Gaps = 41/200 (20%) Query: 328 TSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQL---------------- 371 T + S + + V LTC+ TY+ W + SP+L + Sbjct: 5 TVSKSMSMSVGERVTLTCKASENVVTYVSWYQQKPE-QSPKLLIYGASNRYTGVPDRFTG 63 Query: 372 --SNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYTYY 427 S + TLT+ SV D+ Y CG L + PT+S P + Sbjct: 64 SGSATDFTLTISSVQAEDLADYHCGQGYSYPYTFGGGTKLEIKRADAAPTVSIFPPSSEQ 123 Query: 428 RPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFISNI 467 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 124 LTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKD 183 Query: 468 TEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 184 EYERHNSYTCEATHKTSTSP 203 Score = 43.4 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 40/203 (19%), Positives = 68/203 (33%), Gaps = 45/203 (22%) Query: 148 SISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQL-------------- 193 ++S + S V + V TC+ TY+ W + SP+L + Sbjct: 5 TVSKSMSMSV--GERVTLTCKASENVVTYVSWYQQKPE-QSPKLLIYGASNRYTGVPDRF 61 Query: 194 ----SNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLN 246 S + TLT+ +V D A Y C L + APT+S P + Sbjct: 62 TGSGSATDFTLTISSVQAEDLADYHCGQGYSYPYTFGGGTKLEIKRADAAPTVSIFPPSS 121 Query: 247 TSYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFI 286 SG ++ C + P W ++G+ +Q+ + L + Sbjct: 122 EQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTL 180 Query: 287 PNITVNNSGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 181 TKDEYERHNSYTCEATHKTSTSP 203 Score = 42.2 bits (97), Expect = 9e-04, Method: Composition-based stats. Identities = 36/200 (18%), Positives = 65/200 (32%), Gaps = 41/200 (20%) Query: 504 SISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQS-----------------LPVSPR 546 ++S + S V + V TC+ TY+ W + +P Sbjct: 5 TVSKSMSMSV--GERVTLTCKASENVVTYVSWYQQKPEQSPKLLIYGASNRYTGVPDRFT 62 Query: 547 LQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSS 604 S + TLT+ +V D Y CG S L++ P +S PP S Sbjct: 63 GSGSATDFTLTISSVQAEDLADYHCGQGYSYPYTFGGGTKLEIKRADAAPTVSIFPPSSE 122 Query: 605 YLSGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAK 644 L+ ++ C + + W+I+G +Q+ L + K Sbjct: 123 QLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 182 Query: 645 ITPNNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 183 DEYERHNSYTCEATHKTSTS 202 >1CIC-A nrPDB Length = 214 Score = 48.4 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 36/202 (17%), Positives = 62/202 (30%), Gaps = 39/202 (19%) Query: 325 PFITSNNSNPVEDEDAVALTC---------------EPEIQNTTYLWWVNNQSLPVSPRL 369 S+ D V++TC +P ++W + + V R Sbjct: 3 VMTQSHKFMSTSVGDRVSITCKASQDVRIAVAWYQQKPGQSPKLLIYWASTRHTGVPDRF 62 Query: 370 QLSNDNR--TLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYT 425 S TLT+ +V D+ Y C L + PT+S P + Sbjct: 63 TGSGSGTDFTLTISNVQSEDLADYFCQHCGSYPFTFGSGTKLEIKRADAAPTVSIFPPSS 122 Query: 426 YYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFIS 465 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 123 EQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLDSWTDQDSKDSTYSMSSTLTLT 182 Query: 466 NITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 183 KDEYERHNSYTCEATHKTSTSP 204 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 32/188 (17%), Positives = 56/188 (29%), Gaps = 39/188 (20%) Query: 516 KDAVAFTCEPEAQ-NTTYLWWVNG----------------QSLPVSPRLQLSNGNRTLTL 558 D V+ TC+ W+ +P S + TLT+ Sbjct: 16 GDRVSITCKASQDVRIAVAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGSGSGTDFTLTI 75 Query: 559 FNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSYLSGANLNLSCH 616 NV D Y C S L++ P +S PP S L+ ++ C Sbjct: 76 SNVQSEDLADYFCQHCGSYPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCF 135 Query: 617 SASNPSPQYS--WRINGIPQQHT------------------QVLFIAKITPNNNGTYACF 656 + + W+I+G +Q+ L + K + +Y C Sbjct: 136 LNNFYPKDINVKWKIDGSERQNGVLDSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCE 195 Query: 657 VSNLATGR 664 ++ + Sbjct: 196 ATHKTSTS 203 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 38/201 (18%), Positives = 63/201 (31%), Gaps = 41/201 (20%) Query: 149 ISSNNSKPVEDKDAVAFTCE---------------PETQDATYLWWVNNQSLPVSPRLQL 193 S+ D V+ TC+ P ++W + + V R Sbjct: 5 TQSHKFMSTSVGDRVSITCKASQDVRIAVAWYQQKPGQSPKLLIYWASTRHTGVPDRFTG 64 Query: 194 SNGNR--TLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTS 248 S TLT+ NV D A Y C+ L + APT+S P + Sbjct: 65 SGSGTDFTLTISNVQSEDLADYFCQHCGSYPFTFGSGTKLEIKRADAAPTVSIFPPSSEQ 124 Query: 249 YRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFIPN 288 SG ++ C + P W ++G+ +Q+ + L + Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLDSWTDQDSKDSTYSMSSTLTLTK 183 Query: 289 ITVNNSGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 184 DEYERHNSYTCEATHKTSTSP 204 >4BFI-B nrPDB Length = 211 Score = 48.0 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 28/152 (18%), Positives = 48/152 (31%), Gaps = 12/152 (7%) Query: 60 QHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGR----EIIYPNASLLIQNIIQN 115 Q +W K + V + T PAY R E+ N+S+ N Sbjct: 27 QEPLIVTWQKKKAVSPENMVT--YSKTHGVVIQPAYKDRINVTELGLWNSSITFWNTTLE 84 Query: 116 DTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDAT 175 D G Y T +Y + P + N +D + TC + A Sbjct: 85 DEGCYMCLFNTFGSQKVSGTACLTLYVQ-PIVHLHYN-----YFEDHLNITCSATARPAP 138 Query: 176 YLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTR 207 + W + + + N T ++ ++ R Sbjct: 139 AISWKGTGTGIENSTESHFHSNGTTSVTSILR 170 Score = 47.6 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 24/145 (16%), Positives = 47/145 (32%), Gaps = 29/145 (20%) Query: 518 AVAFTCEP-EAQNTTYLWWVNGQSLPVSPRLQLSNG---------------------NRT 555 + C +Q + W +++ + S N + Sbjct: 16 TASLRCSLKTSQEPLIVTWQKKKAVSPENMVTYSKTHGVVIQPAYKDRINVTELGLWNSS 75 Query: 556 LTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGAN-LNLS 614 +T +N T D Y+C S S L + P + Y + LN++ Sbjct: 76 ITFWNTTLEDEGCYMCLFNTFGSQKVSGTACLTLYVQPIVHL------HYNYFEDHLNIT 129 Query: 615 CHSASNPSPQYSWRINGIPQQHTQV 639 C + + P+P SW+ G +++ Sbjct: 130 CSATARPAPAISWKGTGTGIENSTE 154 Score = 46.1 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 18/105 (17%), Positives = 37/105 (35%), Gaps = 7/105 (6%) Query: 281 TQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDA 340 + N T+ + G Y C + + T +T+Y +P + ED Sbjct: 73 NSSITFWNTTLEDEGCYMCLFNTFGSQKVSGTAC-LTLYVQPIVHLHYNYF------EDH 125 Query: 341 VALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTR 385 + +TC + + W + + + N T ++ S+ R Sbjct: 126 LNITCSATARPAPAISWKGTGTGIENSTESHFHSNGTTSVTSILR 170 Score = 44.5 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 20/87 (22%), Positives = 34/87 (39%), Gaps = 5/87 (5%) Query: 375 NRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLS 434 N ++T + T D G Y C S S L + P + +Y +L+ Sbjct: 73 NSSITFWNTTLEDEGCYMCLFNTFGSQKVSGTACLTLYVQP-IVHLHYNYFE----DHLN 127 Query: 435 LSCHAASNPPAQYSWLIDGNIQQHTQE 461 ++C A + P SW G +++ E Sbjct: 128 ITCSATARPAPAISWKGTGTGIENSTE 154 Score = 38.4 bits (87), Expect = 0.012, Method: Composition-based stats. Identities = 27/151 (17%), Positives = 50/151 (33%), Gaps = 29/151 (19%) Query: 161 DAVAFTCEPETQDAT-YLWWVNNQSLPVSPRLQLSNG---------------------NR 198 + C +T + W +++ + S N Sbjct: 15 TTASLRCSLKTSQEPLIVTWQKKKAVSPENMVTYSKTHGVVIQPAYKDRINVTELGLWNS 74 Query: 199 TLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGEN-LNL 257 ++T +N T D Y C S + S + L + P ++ Y E+ LN+ Sbjct: 75 SITFWNTTLEDEGCYMCLFNTFGSQKVSGTACLTLYVQP------IVHLHYNYFEDHLNI 128 Query: 258 SCHAASNPPAQYSWFVNGTFQQSTQELFIPN 288 +C A + P SW GT +++ E + Sbjct: 129 TCSATARPAPAISWKGTGTGIENSTESHFHS 159 Score = 36.1 bits (81), Expect = 0.051, Method: Composition-based stats. Identities = 19/101 (18%), Positives = 37/101 (36%), Gaps = 9/101 (8%) Query: 459 TQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDA 518 + N T ++ G Y C N+ + +T+ + P + + + +D Sbjct: 73 NSSITFWNTTLEDEGCYMCL-FNTFGSQKVSGTACLTLYVQ---PIVHLHYNYF---EDH 125 Query: 519 VAFTCEPEAQNTTYLWWVN-GQSLPVSPRLQL-SNGNRTLT 557 + TC A+ + W G + S SNG ++T Sbjct: 126 LNITCSATARPAPAISWKGTGTGIENSTESHFHSNGTTSVT 166 >1CT8-A nrPDB Length = 214 Score = 48.0 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 40/203 (19%), Positives = 68/203 (33%), Gaps = 41/203 (20%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQL------------- 371 + + V D+V+L+C + L W +S SPRL + Sbjct: 3 VMTQTPATLSVTPGDSVSLSCRASQSVSNKLHWYQQKSH-ESPRLLIKFASQSIPGIPSR 61 Query: 372 -----SNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSY 424 S + TL++ SV D G Y C + + L + PT+S P Sbjct: 62 FSGSGSGSDFTLSINSVETEDFGIYFCHQTHGRPLTFGAGTKLELKRADAAPTVSIFPPS 121 Query: 425 TYYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFI 464 + S+ C + P + W IDG+ +Q+ + L + Sbjct: 122 SEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTL 181 Query: 465 SNITEKNSGLYTCQANNSASGHS 487 + + YTC+A + S Sbjct: 182 TKDEYERHNSYTCEATHKTSTSP 204 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 36/197 (18%), Positives = 64/197 (32%), Gaps = 41/197 (20%) Query: 153 NSKPVEDKDAVAFTCEPETQDATYLWWVNN--------------QSLPVSPRLQLSNGNR 198 + V D+V+ +C + L W QS+P P +G+ Sbjct: 9 ATLSVTPGDSVSLSCRASQSVSNKLHWYQQKSHESPRLLIKFASQSIPGIPSRFSGSGSG 68 Query: 199 ---TLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTSYRSG 252 TL++ +V D Y C + L + APT+S P + SG Sbjct: 69 SDFTLSINSVETEDFGIYFCHQTHGRPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSG 128 Query: 253 ENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFIPNITVN 292 ++ C + P W ++G+ +Q+ + L + Sbjct: 129 -GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYE 187 Query: 293 NSGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 188 RHNSYTCEATHKTSTSP 204 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 32/198 (16%), Positives = 61/198 (30%), Gaps = 39/198 (19%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQYSWL------------------IDGNIQQHTQ 460 T +P+ PG ++SLSC A+ + + W I G + + Sbjct: 5 TQTPATLSVTPGDSVSLSCRASQSVSNKLHWYQQKSHESPRLLIKFASQSIPGIPSRFSG 64 Query: 461 -------ELFISNITEKNSGLYTCQANNSAS-GHSRTTVKTITVSAELPKPSISSNNSKP 512 L I+++ ++ G+Y C + T + + P SI +S+ Sbjct: 65 SGSGSDFTLSINSVETEDFGIYFCHQTHGRPLTFGAGTKLELKRADAAPTVSIFPPSSEQ 124 Query: 513 VEDKDAVAFTCEPEAQNTT---YLWWVNGQSLPV---------SPRLQLSNGNRTLTLFN 560 + + C W ++G + + + TLTL Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 183 Query: 561 VTRNDARAYVCGIQNSVS 578 +Y C + S Sbjct: 184 DEYERHNSYTCEATHKTS 201 Score = 37.6 bits (85), Expect = 0.019, Method: Composition-based stats. Identities = 34/204 (16%), Positives = 56/204 (27%), Gaps = 49/204 (24%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGT------------------------ 276 T +P S G++++LSC A+ + + W+ + Sbjct: 5 TQTPATLSVTPGDSVSLSCRASQSVSNKLHWYQQKSHESPRLLIKFASQSIPGIPSRFSG 64 Query: 277 -FQQSTQELFIPNITVNNSGSYTCQAHN-SDTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 S L I ++ + G Y C + T + P I +S Sbjct: 65 SGSGSDFTLSINSVETEDFGIYFCHQTHGRPLTFGAGTKLELKRADAAPTVSIFPPSSEQ 124 Query: 335 VEDEDAVALTC-----------------EPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRT 377 + ++ C E QN L +Q S + T Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGV-LNSWTDQDSKDSTYSM----SST 178 Query: 378 LTLLSVTRNDVGPYECGIQNKLSV 401 LTL Y C +K S Sbjct: 179 LTLTKDEYERHNSYTCEATHKTST 202 Score = 36.1 bits (81), Expect = 0.051, Method: Composition-based stats. Identities = 35/220 (15%), Positives = 65/220 (29%), Gaps = 33/220 (15%) Query: 18 LLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNR 77 L++T + T P + + + WY+ + + R Sbjct: 2 LVMTQTPATLSVTP--------------GDSVSLSCRASQSVSNKL--HWYQQKSHESPR 45 Query: 78 QIIGYVIGTQQATPG-PAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATG 136 +I + Q+ PG P+ + +L I ++ D G Y H + A Sbjct: 46 LLIKF---ASQSIPGIPSRFSGSGSGSDFTLSINSVETEDFGIYFCHQTHGRPLTFGAGT 102 Query: 137 QFRVYPELPKPSIS----SNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-------- 184 + + P++S S+ V F +D W ++ Sbjct: 103 KLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNS 162 Query: 185 -LPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSA 223 + + + TLTL SY CE + S Sbjct: 163 WTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTST 202 >3O11-L nrPDB Length = 212 Score = 48.0 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 29/195 (14%), Positives = 56/195 (28%), Gaps = 39/195 (20%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGT------FQQSTQ------------ 282 T SP S GE + ++C A+S+ + W+ + + + Sbjct: 5 TQSPAIMSASPGEKVTMTCSASSS-VSYMHWYQQKSGTSPKRWIYDSSRLASGVPSRFSG 63 Query: 283 -------ELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPV 335 L I N+ ++ +Y CQ S T + P FI + + Sbjct: 64 GGSGTSYSLTISNMEAEDAATYFCQNWRSSPTFGAGTKLELKRTVAAPSVFIFPPSDEQL 123 Query: 336 EDEDAVALTCEPEI--QNTTYLWWV----------NNQSLPVSPRLQLSNDNRTLTLLSV 383 + ++ C + W + + + TLTL Sbjct: 124 KSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKA 182 Query: 384 TRNDVGPYECGIQNK 398 Y C + ++ Sbjct: 183 DYEKHKVYACEVTHQ 197 Score = 43.0 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 30/194 (15%), Positives = 63/194 (32%), Gaps = 37/194 (19%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPP-----------AQYSWLIDGN------------- 454 T SP+ PG ++++C A+S+ + W+ D + Sbjct: 5 TQSPAIMSASPGEKVTMTCSASSSVSYMHWYQQKSGTSPKRWIYDSSRLASGVPSRFSGG 64 Query: 455 IQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVE 514 + L ISN+ +++ Y CQ S+ T + + P I + + ++ Sbjct: 65 GSGTSYSLTISNMEAEDAATYFCQNWRSSPTFGAGTKLELKRTVAAPSVFIFPPSDEQLK 124 Query: 515 DKDAVAFTCEPEAQNT---TYLWWVNGQSLPVSPRLQLS---------NGNRTLTLFNVT 562 + C W V+ + + ++ + + TLTL Sbjct: 125 SG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKAD 183 Query: 563 RNDARAYVCGIQNS 576 + Y C + + Sbjct: 184 YEKHKVYACEVTHQ 197 Score = 35.3 bits (79), Expect = 0.093, Method: Composition-based stats. Identities = 29/178 (16%), Positives = 53/178 (29%), Gaps = 19/178 (10%) Query: 67 WYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIK 126 WY+ + ++ I ++ A+ P+ + SL I N+ D Y + Sbjct: 34 WYQQKSGTSPKRWI--YDSSRLASGVPSRFSGGGSGTSYSLTISNMEAEDAATYFCQNWR 91 Query: 127 SDLVNEEAT-GQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQD--ATYLWWVNN- 182 S T + + P I + + ++ A A W V+N Sbjct: 92 SSPTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNA 151 Query: 183 --------QSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ-----NPVSARRSD 227 + + + TLTL Y CE +PV+ + Sbjct: 152 LQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR 209 >1KNO-A nrPDB Length = 214 Score = 48.0 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 38/201 (18%), Positives = 64/201 (31%), Gaps = 39/201 (19%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQL-------------- 371 S +S + V+LTC + + YL W+ + RL Sbjct: 4 MTQSPSSLSASLGERVSLTCRASQEISGYLSWLQQKPDGTIKRLIYAASTLDSGVPKRFS 63 Query: 372 ---SNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYTY 426 S + +LT+ S+ D Y C L +L PT+S P + Sbjct: 64 GSRSGSDYSLTISSLESEDFADYYCLQYASSPYTFGGGTKLEILRADAAPTVSIFPPSSE 123 Query: 427 YRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFISN 466 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 124 QLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 183 Query: 467 ITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 184 DEYERHNSYTCEATHKTSTSP 204 Score = 44.2 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 37/201 (18%), Positives = 65/201 (32%), Gaps = 41/201 (20%) Query: 149 ISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQL--------------- 193 S +S + V+ TC + + YL W+ + RL Sbjct: 5 TQSPSSLSASLGERVSLTCRASQEISGYLSWLQQKPDGTIKRLIYAASTLDSGVPKRFSG 64 Query: 194 --SNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTS 248 S + +LT+ ++ D A Y C L +L APT+S P + Sbjct: 65 SRSGSDYSLTISSLESEDFADYYCLQYASSPYTFGGGTKLEILRADAAPTVSIFPPSSEQ 124 Query: 249 YRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFIPN 288 SG ++ C + P W ++G+ +Q+ + L + Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 183 Query: 289 ITVNNSGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 184 DEYERHNSYTCEATHKTSTSP 204 Score = 37.6 bits (85), Expect = 0.018, Method: Composition-based stats. Identities = 34/199 (17%), Positives = 60/199 (30%), Gaps = 41/199 (20%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQYSWL---IDGNIQQH----------------- 458 T SPS G +SL+C A+ SWL DG I++ Sbjct: 5 TQSPSSLSASLGERVSLTCRASQEISGYLSWLQQKPDGTIKRLIYAASTLDSGVPKRFSG 64 Query: 459 -----TQELFISNITEKNSGLYTCQ--ANNSASGHSRTTVKTITVSAELPKPSISSNNSK 511 L IS++ ++ Y C A++ + T ++ + A ++ + Sbjct: 65 SRSGSDYSLTISSLESEDFADYYCLQYASSPYTFGGGTKLEILRADAAPTVSIFPPSSEQ 124 Query: 512 PVEDKDAVAFTCEPEAQNTT---YLWWVNGQSLPV---------SPRLQLSNGNRTLTLF 559 +V C W ++G + + + TLTL Sbjct: 125 LTSGGASVV--CFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLT 182 Query: 560 NVTRNDARAYVCGIQNSVS 578 +Y C + S Sbjct: 183 KDEYERHNSYTCEATHKTS 201 >2AEP-L nrPDB Length = 214 Score = 48.0 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 36/201 (17%), Positives = 63/201 (31%), Gaps = 39/201 (19%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS-----------------LPVSPR 368 S D V++TC+ T + W + +P Sbjct: 4 MTQSQKFLSTSVGDRVSVTCKASQNVGTNVAWYQKKPGQSPKPLMYSASYRYSGVPDRFT 63 Query: 369 LQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYTY 426 S + TLT+ +V D+ Y C N+ + L + PT+S P + Sbjct: 64 GSGSGTDFTLTISNVQSEDLAEYFCQQFNRYPLTFGSGTKLELKRADAAPTVSIFPPSSE 123 Query: 427 YRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFISN 466 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 124 QLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 183 Query: 467 ITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 184 DEYERHNSYTCEATHKTSTSP 204 Score = 41.8 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 36/188 (19%), Positives = 61/188 (32%), Gaps = 27/188 (14%) Query: 148 SISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRT---LTLFN 204 +S VA+ + Q L + + P +G+ T LT+ N Sbjct: 18 RVSVTCKASQNVGTNVAWYQKKPGQSPKPLMYSASYRYSGVPDRFTGSGSGTDFTLTISN 77 Query: 205 VTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTSYRSGENLNLSCHA 261 V D A Y C+ N L + APT+S P + SG ++ C Sbjct: 78 VQSEDLAEYFCQQFNRYPLTFGSGTKLELKRADAAPTVSIFPPSSEQLTSG-GASVVCFL 136 Query: 262 ASNPPAQY--SWFVNGTFQQS------------------TQELFIPNITVNNSGSYTCQA 301 + P W ++G+ +Q+ + L + SYTC+A Sbjct: 137 NNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEA 196 Query: 302 HNSDTGLN 309 + + Sbjct: 197 THKTSTSP 204 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 34/198 (17%), Positives = 58/198 (29%), Gaps = 39/198 (19%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTT-YLWWVNG----------------QSLPVSPRLQ 548 S D V+ TC+ T W+ +P Sbjct: 6 QSQKFLSTSVGDRVSVTCKASQNVGTNVAWYQKKPGQSPKPLMYSASYRYSGVPDRFTGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSYL 606 S + TLT+ NV D Y C N L++ P +S PP S L Sbjct: 66 GSGTDFTLTISNVQSEDLAEYFCQQFNRYPLTFGSGTKLELKRADAAPTVSIFPPSSEQL 125 Query: 607 SGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKIT 646 + ++ C + + W+I+G +Q+ L + K Sbjct: 126 TSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDE 185 Query: 647 PNNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 YERHNSYTCEATHKTSTS 203 Score = 38.4 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 33/198 (16%), Positives = 57/198 (28%), Gaps = 39/198 (19%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQYSWLID------------------GNIQQHTQ 460 T S + G +S++C A+ N +W G + T Sbjct: 5 TQSQKFLSTSVGDRVSVTCKASQNVGTNVAWYQKKPGQSPKPLMYSASYRYSGVPDRFTG 64 Query: 461 -------ELFISNITEKNSGLYTCQANNSASGHSRT-TVKTITVSAELPKPSISSNNSKP 512 L ISN+ ++ Y CQ N + T + + P SI +S+ Sbjct: 65 SGSGTDFTLTISNVQSEDLAEYFCQQFNRYPLTFGSGTKLELKRADAAPTVSIFPPSSEQ 124 Query: 513 VEDKDAVAFTCEPEAQNTT---YLWWVNGQSLPV---------SPRLQLSNGNRTLTLFN 560 + + C W ++G + + + TLTL Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 183 Query: 561 VTRNDARAYVCGIQNSVS 578 +Y C + S Sbjct: 184 DEYERHNSYTCEATHKTS 201 >1E4W-L nrPDB Length = 214 Score = 47.6 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 34/201 (16%), Positives = 61/201 (30%), Gaps = 39/201 (19%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRL---------------- 369 + +S D V ++C + YL W + L Sbjct: 4 MTQTPSSLSASLGDRVTISCRASQDISHYLNWFQQKPDGTVKLLIYYTSTLHSGVPSRFS 63 Query: 370 -QLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYTY 426 S + +LT+ ++ D+ Y C L L + PT+S P + Sbjct: 64 GSGSGTDYSLTISNLEEEDIAFYFCQQGGALPFTFGSGTKLAIKRADAAPTVSIFPPSSE 123 Query: 427 YRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFISN 466 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 124 QLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLDSWTDQDSKDSTYSMSSTLTLTK 183 Query: 467 ITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 184 DEYERHNSYTCEATHKTSTSP 204 Score = 46.5 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 30/198 (15%), Positives = 59/198 (29%), Gaps = 39/198 (19%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTY-LWWVNG----------------QSLPVSPRLQ 548 + +S D V +C + Y W+ +P Sbjct: 6 QTPSSLSASLGDRVTISCRASQDISHYLNWFQQKPDGTVKLLIYYTSTLHSGVPSRFSGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSYL 606 S + +LT+ N+ D Y C ++ L + P +S PP S L Sbjct: 66 GSGTDYSLTISNLEEEDIAFYFCQQGGALPFTFGSGTKLAIKRADAAPTVSIFPPSSEQL 125 Query: 607 SGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKIT 646 + ++ C + + W+I+G +Q+ L + K Sbjct: 126 TSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLDSWTDQDSKDSTYSMSSTLTLTKDE 185 Query: 647 PNNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 YERHNSYTCEATHKTSTS 203 Score = 42.6 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 35/197 (17%), Positives = 62/197 (31%), Gaps = 41/197 (20%) Query: 153 NSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRLQLSN 195 +S D V +C + YL W + +P S Sbjct: 9 SSLSASLGDRVTISCRASQDISHYLNWFQQKPDGTVKLLIYYTSTLHSGVPSRFSGSGSG 68 Query: 196 GNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTSYRSG 252 + +LT+ N+ D A Y C+ + L + APT+S P + SG Sbjct: 69 TDYSLTISNLEEEDIAFYFCQQGGALPFTFGSGTKLAIKRADAAPTVSIFPPSSEQLTSG 128 Query: 253 ENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFIPNITVN 292 ++ C + P W ++G+ +Q+ + L + Sbjct: 129 -GASVVCFLNNFYPKDINVKWKIDGSERQNGVLDSWTDQDSKDSTYSMSSTLTLTKDEYE 187 Query: 293 NSGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 188 RHNSYTCEATHKTSTSP 204 Score = 34.5 bits (77), Expect = 0.15, Method: Composition-based stats. Identities = 31/198 (15%), Positives = 54/198 (27%), Gaps = 37/198 (18%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T +P + S G+ + +SC A+ + +WF G Sbjct: 5 TQTPSSLSASLGDRVTISCRASQDISHYLNWFQQKPDGTVKLLIYYTSTLHSGVPSRFSG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQ--AHNSDTGLNRTTVTTITVYAEPPKPFITSNNSN 333 + + L I N+ + Y CQ T + T + A P ++ Sbjct: 65 SGSGTDYSLTISNLEEEDIAFYFCQQGGALPFTFGSGTKLAIKRADAAPTVSIFPPSSEQ 124 Query: 334 PVEDEDAVALTCEPEIQNTTYLWWVNNQS----------LPVSPRLQLSNDNRTLTLLSV 383 +V + W + S + + + TLTL Sbjct: 125 LTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLDSWTDQDSKDSTYSMSSTLTLTKD 184 Query: 384 TRNDVGPYECGIQNKLSV 401 Y C +K S Sbjct: 185 EYERHNSYTCEATHKTST 202 Score = 33.0 bits (73), Expect = 0.47, Method: Composition-based stats. Identities = 35/207 (16%), Positives = 64/207 (30%), Gaps = 31/207 (14%) Query: 37 TIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYS 96 T S ++ + + H +W++ ++ DG +++ Y T + +S Sbjct: 7 TPSSLSASLGDRVTISCRASQDISHYL--NWFQ-QKPDGTVKLLIYYTSTLHSGVPSRFS 63 Query: 97 GREIIYPNASLLIQNIIQNDTGFYTLH-----------VIKSDLVNEEATGQFRVYPELP 145 G + SL I N+ + D FY K + +A ++P Sbjct: 64 GSGSGT-DYSLTISNLEEEDIAFYFCQQGGALPFTFGSGTKLAIKRADAAPTVSIFPPSS 122 Query: 146 KPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS---------LPVSPRLQLSNG 196 + S S V F +D W ++ + + Sbjct: 123 EQLTSGGASV-------VCFLNNFYPKDINVKWKIDGSERQNGVLDSWTDQDSKDSTYSM 175 Query: 197 NRTLTLFNVTRNDTASYKCETQNPVSA 223 + TLTL SY CE + S Sbjct: 176 SSTLTLTKDEYERHNSYTCEATHKTST 202 >1KCR-L nrPDB Length = 213 Score = 47.6 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 39/203 (19%), Positives = 64/203 (31%), Gaps = 42/203 (20%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQL------------- 371 S S + + V L+C+ TY+ W + SP+L + Sbjct: 3 VLTQSPKSMSMSVGERVTLSCKASENVGTYVSWYQQKPE-QSPKLLIYGASNRYTGVPDR 61 Query: 372 -----SNDNRTLTLLSVTRNDVGPYECGIQ-NKLSVDHSDP-VILNVLYGPDDPTISPSY 424 S + TL + SV D+ Y CG + + I P PS Sbjct: 62 FTGSGSATDFTLKISSVQAEDLADYHCGQTYSYPTFGGGTKLAIKRADAAPTVSIFPPSS 121 Query: 425 TYYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFI 464 G S+ C + P + W IDG+ +Q+ + L + Sbjct: 122 EQLTAG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVANSWTAQDSADSTYSMSSTLTL 180 Query: 465 SNITEKNSGLYTCQANNSASGHS 487 + + YTC+A + S Sbjct: 181 TKDEYERHNSYTCEATHKTSTSP 203 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 34/197 (17%), Positives = 54/197 (27%), Gaps = 36/197 (18%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP + S GE + LSC A+ N SW+ G Sbjct: 5 TQSPKSMSMSVGERVTLSCKASENVGTYVSWYQQKPEQSPKLLIYGASNRYTGVPDRFTG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTC-QAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 + + L I ++ + Y C Q ++ T T + A P ++ Sbjct: 65 SGSATDFTLKISSVQAEDLADYHCGQTYSYPTFGGGTKLAIKRADAAPTVSIFPPSSEQL 124 Query: 335 VEDEDAVALTCEPEIQNTTYLWWVNNQS----------LPVSPRLQLSNDNRTLTLLSVT 384 +V + W + S + + TLTL Sbjct: 125 TAGGASVVCFLNNFYPKDINVKWKIDGSERQNGVANSWTAQDSADSTYSMSSTLTLTKDE 184 Query: 385 RNDVGPYECGIQNKLSV 401 Y C +K S Sbjct: 185 YERHNSYTCEATHKTST 201 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 33/198 (16%), Positives = 60/198 (30%), Gaps = 40/198 (20%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQS-----------------LPVSPRLQ 548 S S + + V +C+ TY+ W + +P Sbjct: 6 QSPKSMSMSVGERVTLSCKASENVGTYVSWYQQKPEQSPKLLIYGASNRYTGVPDRFTGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSYL 606 S + TL + +V D Y CG Q L + P +S PP S L Sbjct: 66 GSATDFTLKISSVQAEDLADYHCG-QTYSYPTFGGGTKLAIKRADAAPTVSIFPPSSEQL 124 Query: 607 SGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKIT 646 + ++ C + + W+I+G +Q+ L + K Sbjct: 125 TAGGASVVCFLNNFYPKDINVKWKIDGSERQNGVANSWTAQDSADSTYSMSSTLTLTKDE 184 Query: 647 PNNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 185 YERHNSYTCEATHKTSTS 202 Score = 39.2 bits (89), Expect = 0.007, Method: Composition-based stats. Identities = 37/202 (18%), Positives = 65/202 (32%), Gaps = 44/202 (21%) Query: 149 ISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQL--------------- 193 S S + + V +C+ TY+ W + SP+L + Sbjct: 5 TQSPKSMSMSVGERVTLSCKASENVGTYVSWYQQKPE-QSPKLLIYGASNRYTGVPDRFT 63 Query: 194 ---SNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNT 247 S + TL + +V D A Y C Q L + APT+S P + Sbjct: 64 GSGSATDFTLKISSVQAEDLADYHC-GQTYSYPTFGGGTKLAIKRADAAPTVSIFPPSSE 122 Query: 248 SYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFIP 287 +G ++ C + P W ++G+ +Q+ + L + Sbjct: 123 QLTAG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVANSWTAQDSADSTYSMSSTLTLT 181 Query: 288 NITVNNSGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 182 KDEYERHNSYTCEATHKTSTSP 203 >1HNF-A nrPDB Length = 182 Score = 47.2 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 23/117 (19%), Positives = 43/117 (36%), Gaps = 7/117 (5%) Query: 375 NRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVI-LNVLYGPDDPTISPSYTYYRPGVNL 433 N TL + + +D Y+ I + + + + L + P IS + +N Sbjct: 65 NGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTC------INT 118 Query: 434 SLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTT 490 +L+C + + + DG + +Q + T S + C A N S S Sbjct: 119 TLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVE 175 Score = 39.2 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 21/146 (14%), Positives = 45/146 (30%), Gaps = 7/146 (4%) Query: 168 EPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSD 227 E + + + N TL + ++ +D YK + + Sbjct: 36 EKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLE 95 Query: 228 SVI-LNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFI 286 + L + P IS N L+C + + + + +G + +Q + Sbjct: 96 KIFDLKIQERVSKPKISWTCI------NTTLTCEVMNGTDPELNLYQDGKHLKLSQRVIT 149 Query: 287 PNITVNNSGSYTCQAHNSDTGLNRTT 312 T + S + C A N + + Sbjct: 150 HKWTTSLSAKFKCTAGNKVSKESSVE 175 Score = 34.9 bits (78), Expect = 0.13, Method: Composition-based stats. Identities = 26/130 (20%), Positives = 47/130 (36%), Gaps = 18/130 (13%) Query: 101 IYPNASLLIQNIIQNDTGFYTLHVIKSDLVNE-EATGQFRVYPELPKPSISSNNSKPVED 159 ++ N +L I+++ +D Y + + + N E ++ + KP IS Sbjct: 62 LFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINT--- 118 Query: 160 KDAVAFTCEPETQDATYL-WWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ 218 TCE L + + + L +S R+ +L +A +KC Sbjct: 119 ----TLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSL---------SAKFKCTAG 165 Query: 219 NPVSARRSDS 228 N VS S Sbjct: 166 NKVSKESSVE 175 >3QS7-E nrPDB Length = 423 Score = 47.2 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 60/340 (17%), Positives = 106/340 (31%), Gaps = 50/340 (14%) Query: 148 SISSNNSKPVEDKDAVAFTCEPE---------TQDATYLWWVNNQSLPVSPRLQLSN-GN 197 ++ +S V + AV + + LW + SL P L N G Sbjct: 43 ALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGV 102 Query: 198 RTLTLFNVTRNDTASYKCETQNPVSAR---RSDSVILNVLYGPDAPTIS-PLNTSYRSGE 253 ++ + +T Y Q+ + + S+ +LY P N Sbjct: 103 VSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDA---- 158 Query: 254 NLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNS-------GSYT-CQAHNSD 305 L C + S P W + Q + + P + G+ C A N + Sbjct: 159 ---LVCISESVPEPIVEWVL-CDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARN-E 213 Query: 306 TGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEP-EIQNTTYLWWV-NNQSL 363 G T + TI + P V + + + C+ + + L W N++L Sbjct: 214 LGRECTRLFTIDLNQTPQTTL--PQLFLKV--GEPLWIRCKAVHVNHGFGLTWELENKAL 269 Query: 364 PVSPRLQLS--NDNRTL------TLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGP 415 ++S + NRT+ + SV RND G Y C S S ++ ++ Sbjct: 270 EEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSS----SKHPSQSALVTIVEKG 325 Query: 416 DDPTISPSYT-YYRPGVNLSLSCHAASNPPAQYSWLIDGN 454 + S S + P + +W Sbjct: 326 FINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRK 365 Score = 37.2 bits (84), Expect = 0.026, Method: Composition-based stats. Identities = 38/242 (15%), Positives = 70/242 (28%), Gaps = 48/242 (19%) Query: 462 LFISNITEKNSGLYT----CQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKD 517 + I +TE +G Y +A N + + T+ + P N V Sbjct: 105 MVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALV---- 160 Query: 518 AVAFTCEPEAQNTTYLWWV----NGQSLPVSPRLQLSNGNRTL-TLFNVTRNDARAYVCG 572 C E+ + WV G+S + + L LF C Sbjct: 161 -----CISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIR------CC 209 Query: 573 IQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQ-YSWRING 631 +N + + T+D+ P T + P G L + C + +W + Sbjct: 210 ARNELGRECTRLFTIDLNQTPQTTL---PQLFLKVGEPLWIRCKAVHVNHGFGLTWELEN 266 Query: 632 IPQQHTQVL-----------------FIAKITPNNNGTYACFVSNLATGRNNSIVKSITV 674 + F++ + N+ G Y C + + S + +I Sbjct: 267 KALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCS---SSKHPSQSALVTIVE 323 Query: 675 SA 676 Sbjct: 324 KG 325 Score = 32.6 bits (72), Expect = 0.53, Method: Composition-based stats. Identities = 26/188 (13%), Positives = 59/188 (31%), Gaps = 16/188 (8%) Query: 33 TAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPG 92 T + T+ V E + ++ H FG +W ++ + Sbjct: 229 TPQTTLPQLFLKVGEPLWIRCKAVHV-NHGFGLTW----------ELENKALEEGNYFEM 277 Query: 93 PAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSN 152 YS + + ++ +NDTG+YT K + + + + + +S+ Sbjct: 278 STYSTNRTMIRILFAFVSSVARNDTGYYTCSSSK----HPSQSALVTIVEKGFINATNSS 333 Query: 153 NSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTAS 212 ++ + F+ + W ++ + L NG N ++ Sbjct: 334 EDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCN-HKHQPGE 392 Query: 213 YKCETQNP 220 Y +N Sbjct: 393 YIFHAEND 400 >1FNS-L nrPDB Length = 214 Score = 47.2 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 37/201 (18%), Positives = 61/201 (30%), Gaps = 39/201 (19%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQL-------------- 371 S +S D V ++C YL W + L Sbjct: 4 MTQSPSSLSASLGDRVTISCSASQDINKYLNWYQQKPDGAVKLLIFYTSSLHSGVPSRFS 63 Query: 372 ---SNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYTY 426 S + +LT+ ++ D+ Y C KL L V PT+S P + Sbjct: 64 GSGSGTDYSLTISNLEPEDIATYYCQQYEKLPWTFGGGTKLEVKRADAAPTVSIFPPSSE 123 Query: 427 YRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFISN 466 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 124 QLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 183 Query: 467 ITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 184 DEYERHNSYTCEATHKTSTSP 204 Score = 43.0 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 37/201 (18%), Positives = 63/201 (31%), Gaps = 41/201 (20%) Query: 149 ISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRL 191 S +S D V +C YL W + +P Sbjct: 5 TQSPSSLSASLGDRVTISCSASQDINKYLNWYQQKPDGAVKLLIFYTSSLHSGVPSRFSG 64 Query: 192 QLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTS 248 S + +LT+ N+ D A+Y C+ + L V APT+S P + Sbjct: 65 SGSGTDYSLTISNLEPEDIATYYCQQYEKLPWTFGGGTKLEVKRADAAPTVSIFPPSSEQ 124 Query: 249 YRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFIPN 288 SG ++ C + P W ++G+ +Q+ + L + Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 183 Query: 289 ITVNNSGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 184 DEYERHNSYTCEATHKTSTSP 204 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 32/198 (16%), Positives = 58/198 (29%), Gaps = 39/198 (19%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTY-LWWVNG----------------QSLPVSPRLQ 548 S +S D V +C Y W+ +P Sbjct: 6 QSPSSLSASLGDRVTISCSASQDINKYLNWYQQKPDGAVKLLIFYTSSLHSGVPSRFSGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSYL 606 S + +LT+ N+ D Y C + L+V P +S PP S L Sbjct: 66 GSGTDYSLTISNLEPEDIATYYCQQYEKLPWTFGGGTKLEVKRADAAPTVSIFPPSSEQL 125 Query: 607 SGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKIT 646 + ++ C + + W+I+G +Q+ L + K Sbjct: 126 TSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDE 185 Query: 647 PNNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 YERHNSYTCEATHKTSTS 203 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 34/202 (16%), Positives = 56/202 (27%), Gaps = 45/202 (22%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP + S G+ + +SC A+ + +W+ G Sbjct: 5 TQSPSSLSASLGDRVTISCSASQDINKYLNWYQQKPDGAVKLLIFYTSSLHSGVPSRFSG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQA-----HNSDTGLN---RTTVTTITVYAEPPKPF- 326 + + L I N+ + +Y CQ G + TV PP Sbjct: 65 SGSGTDYSLTISNLEPEDIATYYCQQYEKLPWTFGGGTKLEVKRADAAPTVSIFPPSSEQ 124 Query: 327 -------ITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLT 379 + +N + V + + L +Q S + TLT Sbjct: 125 LTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSM----SSTLT 180 Query: 380 LLSVTRNDVGPYECGIQNKLSV 401 L Y C +K S Sbjct: 181 LTKDEYERHNSYTCEATHKTST 202 Score = 30.7 bits (67), Expect = 2.5, Method: Composition-based stats. Identities = 27/175 (15%), Positives = 51/175 (29%), Gaps = 23/175 (13%) Query: 66 SWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHV- 124 +WY+ ++ DG +++ + + + +SG + SL I N+ D Y Sbjct: 34 NWYQ-QKPDGAVKLLIFYTSSLHSGVPSRFSGSGSGT-DYSLTISNLEPEDIATYYCQQY 91 Query: 125 -----IKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATY--L 177 + + P SI +S+ + A Sbjct: 92 EKLPWTFGGGT----KLEVKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVK 147 Query: 178 WWVNNQS---------LPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSA 223 W ++ + + + TLTL SY CE + S Sbjct: 148 WKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTST 202 >2AJV-L nrPDB Length = 216 Score = 46.9 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 41/207 (19%), Positives = 66/207 (31%), Gaps = 44/207 (21%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNT-----TYLWWV---------------NNQSLP 364 SNPV ++V+++C TYL W + ++ Sbjct: 3 VITQDELSNPVTSGESVSISCRSSRSLLYKDGRTYLNWFLQRPGQSPQLLIYLMSTRASG 62 Query: 365 VSPRLQLSNDNR--TLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS- 421 VS R S TL + V DVG Y C + L + PT+S Sbjct: 63 VSDRFSGSGSGTDFTLEISRVKAEDVGVYYCQQFVEYPFTFGSGTKLEIKRADAAPTVSI 122 Query: 422 -PSYTYYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQ 460 P + S+ C + P + W IDG+ +Q+ + Sbjct: 123 FPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSS 182 Query: 461 ELFISNITEKNSGLYTCQANNSASGHS 487 L ++ + YTC+A + S Sbjct: 183 TLTLTKDEYERHNSYTCEATHKTSTSP 209 Score = 39.9 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 34/187 (18%), Positives = 60/187 (32%), Gaps = 28/187 (14%) Query: 150 SSNNSKPVEDKDAVA--FTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNR--TLTLFNV 205 S+ S +D F P ++ ++ ++ VS R S TL + V Sbjct: 24 RSSRSLLYKDGRTYLNWFLQRPGQSPQLLIYLMSTRASGVSDRFSGSGSGTDFTLEISRV 83 Query: 206 TRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTSYRSGENLNLSCHAA 262 D Y C+ L + APT+S P + SG ++ C Sbjct: 84 KAEDVGVYYCQQFVEYPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSG-GASVVCFLN 142 Query: 263 SNPPAQY--SWFVNGTFQQS------------------TQELFIPNITVNNSGSYTCQAH 302 + P W ++G+ +Q+ + L + SYTC+A Sbjct: 143 NFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEAT 202 Query: 303 NSDTGLN 309 + + Sbjct: 203 HKTSTSP 209 Score = 37.2 bits (84), Expect = 0.025, Method: Composition-based stats. Identities = 34/198 (17%), Positives = 62/198 (31%), Gaps = 18/198 (9%) Query: 395 IQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGN 454 + + SV S ++LY D ++ RPG + L + S + S G+ Sbjct: 13 VTSGESVSISCRSSRSLLYK--DGRTYLNWFLQRPGQSPQLLIYLMSTRASGVSDRFSGS 70 Query: 455 IQQHTQELFISNITEKNSGLYTCQ--ANNSASGHSRTTVKTITVSAELPKPSISSNNSKP 512 L IS + ++ G+Y CQ + S T ++ A ++ + Sbjct: 71 GSGTDFTLEISRVKAEDVGVYYCQQFVEYPFTFGSGTKLEIKRADAAPTVSIFPPSSEQL 130 Query: 513 VEDKDAVAFTCEPEAQNTT---YLWWVNGQSLPV---------SPRLQLSNGNRTLTLFN 560 +V C W ++G + + + TLTL Sbjct: 131 TSGGASVV--CFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 188 Query: 561 VTRNDARAYVCGIQNSVS 578 +Y C + S Sbjct: 189 DEYERHNSYTCEATHKTS 206 Score = 34.9 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 32/199 (16%), Positives = 61/199 (30%), Gaps = 44/199 (22%) Query: 510 SKPVEDKDAVAFTCEP-------------------EAQNTTYLWWVNGQSLP-VSPRLQL 549 S PV ++V+ +C Q+ L ++ VS R Sbjct: 10 SNPVTSGESVSISCRSSRSLLYKDGRTYLNWFLQRPGQSPQLLIYLMSTRASGVSDRFSG 69 Query: 550 SNG--NRTLTLFNVTRNDARAYVCG--IQNSVSANRSDPVTLDVLYGPDTPIISPPDSSY 605 S + TL + V D Y C ++ + + + T I PP S Sbjct: 70 SGSGTDFTLEISRVKAEDVGVYYCQQFVEYPFTFGSGTKLEIKRADAAPTVSIFPPSSEQ 129 Query: 606 LSGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKI 645 L+ ++ C + + W+I+G +Q+ L + K Sbjct: 130 LTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKD 189 Query: 646 TPNNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 190 EYERHNSYTCEATHKTSTS 208 Score = 31.1 bits (68), Expect = 1.9, Method: Composition-based stats. Identities = 32/200 (16%), Positives = 61/200 (30%), Gaps = 18/200 (9%) Query: 40 STPFNVAEGKEVLLLVHNLPQHLFGYS---WYKGERVDGNRQIIGYVIGTQQATPGPAYS 96 S P E + + G + W+ +R + Q++ Y++ T+ + +S Sbjct: 10 SNPVTSGESVSISCRSSRSLLYKDGRTYLNWFL-QRPGQSPQLLIYLMSTRASGVSDRFS 68 Query: 97 GREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSIS----SN 152 G + +L I + D G Y + + + P++S S+ Sbjct: 69 GSGSGT-DFTLEISRVKAEDVGVYYCQQFVEYPFTFGSGTKLEIKRADAAPTVSIFPPSS 127 Query: 153 NSKPVEDKDAVAFTCEPETQDATYLWWVNNQS---------LPVSPRLQLSNGNRTLTLF 203 V F +D W ++ + + + TLTL Sbjct: 128 EQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLT 187 Query: 204 NVTRNDTASYKCETQNPVSA 223 SY CE + S Sbjct: 188 KDEYERHNSYTCEATHKTST 207 >1AHW-A nrPDB Length = 214 Score = 46.9 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 36/201 (17%), Positives = 62/201 (30%), Gaps = 39/201 (19%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS---------------LPVSPRLQ 370 S +S + V +TC+ YL W + V R Sbjct: 4 MTQSPSSMYASLGERVTITCKASQDIRKYLNWYQQKPWKSPKTLIYYATSLADGVPSRFS 63 Query: 371 LSNDNR--TLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYTY 426 S + +LT+ S+ +D Y C + L + PT+S P + Sbjct: 64 GSGSGQDYSLTISSLESDDTATYYCLQHGESPYTFGGGTKLEINRADAAPTVSIFPPSSE 123 Query: 427 YRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFISN 466 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 124 QLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 183 Query: 467 ITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 184 DEYERHNSYTCEATHKTSTSP 204 Score = 41.8 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 36/203 (17%), Positives = 64/203 (31%), Gaps = 41/203 (20%) Query: 147 PSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSP 189 S +S + V TC+ YL W + +P Sbjct: 3 KMTQSPSSMYASLGERVTITCKASQDIRKYLNWYQQKPWKSPKTLIYYATSLADGVPSRF 62 Query: 190 RLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLN 246 S + +LT+ ++ +DTA+Y C L + APT+S P + Sbjct: 63 SGSGSGQDYSLTISSLESDDTATYYCLQHGESPYTFGGGTKLEINRADAAPTVSIFPPSS 122 Query: 247 TSYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFI 286 SG ++ C + P W ++G+ +Q+ + L + Sbjct: 123 EQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTL 181 Query: 287 PNITVNNSGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 182 TKDEYERHNSYTCEATHKTSTSP 204 Score = 41.1 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 30/198 (15%), Positives = 59/198 (29%), Gaps = 39/198 (19%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTY-LWWVNG----------------QSLPVSPRLQ 548 S +S + V TC+ Y W+ +P Sbjct: 6 QSPSSMYASLGERVTITCKASQDIRKYLNWYQQKPWKSPKTLIYYATSLADGVPSRFSGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSYL 606 S + +LT+ ++ +D Y C L++ P +S PP S L Sbjct: 66 GSGQDYSLTISSLESDDTATYYCLQHGESPYTFGGGTKLEINRADAAPTVSIFPPSSEQL 125 Query: 607 SGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKIT 646 + ++ C + + W+I+G +Q+ L + K Sbjct: 126 TSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDE 185 Query: 647 PNNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 YERHNSYTCEATHKTSTS 203 Score = 37.2 bits (84), Expect = 0.028, Method: Composition-based stats. Identities = 34/198 (17%), Positives = 59/198 (29%), Gaps = 39/198 (19%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQYSWLI------------------DGNIQQHT- 459 T SPS Y G ++++C A+ + +W DG + + Sbjct: 5 TQSPSSMYASLGERVTITCKASQDIRKYLNWYQQKPWKSPKTLIYYATSLADGVPSRFSG 64 Query: 460 ------QELFISNITEKNSGLYTC-QANNSASGHSRTTVKTITVSAELPKPSISSNNSKP 512 L IS++ ++ Y C Q S T I + P SI +S+ Sbjct: 65 SGSGQDYSLTISSLESDDTATYYCLQHGESPYTFGGGTKLEINRADAAPTVSIFPPSSEQ 124 Query: 513 VEDKDAVAFTCEPEAQNTT---YLWWVNGQSLPV---------SPRLQLSNGNRTLTLFN 560 + + C W ++G + + + TLTL Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 183 Query: 561 VTRNDARAYVCGIQNSVS 578 +Y C + S Sbjct: 184 DEYERHNSYTCEATHKTS 201 Score = 36.8 bits (83), Expect = 0.035, Method: Composition-based stats. Identities = 34/204 (16%), Positives = 57/204 (27%), Gaps = 49/204 (24%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQ---------------------- 278 T SP + GE + ++C A+ + +W+ ++ Sbjct: 5 TQSPSSMYASLGERVTITCKASQDIRKYLNWYQQKPWKSPKTLIYYATSLADGVPSRFSG 64 Query: 279 ---QSTQELFIPNITVNNSGSYTCQAH-NSDTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 L I ++ +++ +Y C H S T I P I +S Sbjct: 65 SGSGQDYSLTISSLESDDTATYYCLQHGESPYTFGGGTKLEINRADAAPTVSIFPPSSEQ 124 Query: 335 VEDEDAVALTC-----------------EPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRT 377 + ++ C E QN L +Q S + T Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGV-LNSWTDQDSKDSTYSM----SST 178 Query: 378 LTLLSVTRNDVGPYECGIQNKLSV 401 LTL Y C +K S Sbjct: 179 LTLTKDEYERHNSYTCEATHKTST 202 Score = 29.9 bits (65), Expect = 4.2, Method: Composition-based stats. Identities = 33/203 (16%), Positives = 60/203 (29%), Gaps = 15/203 (7%) Query: 34 AKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGP 93 K+T + + G+ V + +WY+ + + +I Y P Sbjct: 2 IKMTQSPSSMYASLGERVTITCKASQDIRKYLNWYQQKPWKSPKTLIYYATSLADGVPS- 60 Query: 94 AYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSIS--- 150 +SG + SL I ++ +DT Y + + P++S Sbjct: 61 RFSGSG-SGQDYSLTISSLESDDTATYYCLQHGESPYTFGGGTKLEINRADAAPTVSIFP 119 Query: 151 -SNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS---------LPVSPRLQLSNGNRTL 200 S+ V F +D W ++ + + + TL Sbjct: 120 PSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTL 179 Query: 201 TLFNVTRNDTASYKCETQNPVSA 223 TL SY CE + S Sbjct: 180 TLTKDEYERHNSYTCEATHKTST 202 >4XNZ-L nrPDB Length = 209 Score = 46.9 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 30/201 (14%), Positives = 60/201 (29%), Gaps = 23/201 (11%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVS--------------PRL--QL 549 S + V + C+ + W+ + P R Sbjct: 6 QSPGTLSVSPGERATLFCKASQGGNSLSWYQKRRGQPPRLLIYDTSRRASGIPDRFVGSG 65 Query: 550 SNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGA 609 S + +LT+ V R+D Y C + + V + I PP L Sbjct: 66 SGTDFSLTITKVDRDDFALYFCQQFEFFGLGTALEINRTVAAP--SVFIFPPSDEQLKSG 123 Query: 610 NLNLSCHSASNPS--PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNS 667 ++ C + + W+++ Q + + ++ TY+ + + + Sbjct: 124 TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTLSKADYE 182 Query: 668 IVKSITVSASGTSPGLSAGAT 688 K + T GLS+ T Sbjct: 183 KHKVY--ACEVTHQGLSSPVT 201 Score = 39.5 bits (90), Expect = 0.006, Method: Composition-based stats. Identities = 30/194 (15%), Positives = 53/194 (27%), Gaps = 40/194 (20%) Query: 419 TISPSYTYYRPGVNLSLSCHAA-------------SNPPA----QYSWLIDGNIQQHTQE 461 T SP PG +L C A+ PP S G + Sbjct: 5 TQSPGTLSVSPGERATLFCKASQGGNSLSWYQKRRGQPPRLLIYDTSRRASGIPDRFVGS 64 Query: 462 -------LFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVE 514 L I+ + + LY CQ + I + P I + + ++ Sbjct: 65 GSGTDFSLTITKVDRDDFALYFCQQFEFFGLGTA---LEINRTVAAPSVFIFPPSDEQLK 121 Query: 515 DKDAVAFTCEPEAQNT---TYLWWVNGQSLPVSPRLQLS---------NGNRTLTLFNVT 562 + C W V+ + + ++ + + TLTL Sbjct: 122 SG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKAD 180 Query: 563 RNDARAYVCGIQNS 576 + Y C + + Sbjct: 181 YEKHKVYACEVTHQ 194 Score = 39.2 bits (89), Expect = 0.007, Method: Composition-based stats. Identities = 30/194 (15%), Positives = 49/194 (25%), Gaps = 40/194 (20%) Query: 241 TISPLNTSYRSGENLNLSCHAA-------------SNPPAQYSW-----------FVNGT 276 T SP S GE L C A+ PP + G+ Sbjct: 5 TQSPGTLSVSPGERATLFCKASQGGNSLSWYQKRRGQPPRLLIYDTSRRASGIPDRFVGS 64 Query: 277 FQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVE 336 + L I + ++ Y CQ T I P FI + ++ Sbjct: 65 GSGTDFSLTITKVDRDDFALYFCQQFEFFGL---GTALEINRTVAAPSVFIFPPSDEQLK 121 Query: 337 DEDAVALTCEPEI--QNTTYLWWV----------NNQSLPVSPRLQLSNDNRTLTLLSVT 384 ++ C + W + + + TLTL Sbjct: 122 SG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKAD 180 Query: 385 RNDVGPYECGIQNK 398 Y C + ++ Sbjct: 181 YEKHKVYACEVTHQ 194 Score = 38.0 bits (86), Expect = 0.016, Method: Composition-based stats. Identities = 29/178 (16%), Positives = 52/178 (29%), Gaps = 20/178 (11%) Query: 66 SWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVI 125 SWY+ R R +I Y + + + G + SL I + ++D Y Sbjct: 33 SWYQKRRGQPPRLLI-YDTSRRASGIPDRFVGSGSGT-DFSLTITKVDRDDFALYFCQQF 90 Query: 126 KSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQD--ATYLWWVNN- 182 + + + P I + + ++ A A W V+N Sbjct: 91 EFFGLGT--ALEINRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNA 148 Query: 183 --------QSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ-----NPVSARRSD 227 + + + TLTL Y CE +PV+ + Sbjct: 149 LQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR 206 >1Q0Y-L nrPDB Length = 212 Score = 46.5 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 40/206 (19%), Positives = 59/206 (28%), Gaps = 42/206 (20%) Query: 148 SISSNNSKPVEDKDAVAFTCEPETQDAT---YLWWVNNQS-----------------LPV 187 ++ ++ + V TC T T Y WV + +P Sbjct: 3 VVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRAPGVPA 62 Query: 188 SPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAP---TISP 244 L LT+ D A Y C + L VL P + T+ P Sbjct: 63 RFSGSLIGDKAALTITGAQTEDEAIYFCALWSNNKLVFGGGTKLTVLGQPKSSPTVTLFP 122 Query: 245 LNTSYRSGENLNLSCHAASNPPA--QYSWFVNGTFQQSTQELFIPNITVNNS-------- 294 ++ S L C P W V+GT + E P+ NN Sbjct: 123 PSSEELSTAKATLVCTITDFYPGVVTVDWKVDGTPVTAGMETTQPSKQSNNKYMASSYLT 182 Query: 295 ---------GSYTCQAHNSDTGLNRT 311 SY+CQ + N+T Sbjct: 183 LTARAWERHSSYSCQVTHEGHSSNKT 208 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 35/206 (16%), Positives = 63/206 (30%), Gaps = 42/206 (20%) Query: 505 ISSNNSKPVEDKDAVAFTCEPEAQNTT---YLWWVNGQS-----------------LPVS 544 ++ ++ + V TC T Y WV + +P Sbjct: 4 VTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRAPGVPAR 63 Query: 545 PRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTP---IISPP 601 L LT+ D Y C + ++ L VL P + + PP Sbjct: 64 FSGSLIGDKAALTITGAQTEDEAIYFCALWSNNKLVFGGGTKLTVLGQPKSSPTVTLFPP 123 Query: 602 DSSYLSGANLNLSCHSASNPS--PQYSWRINGIP------------QQHTQVLFIAKITP 647 S LS A L C W+++G P Q + + + + +T Sbjct: 124 SSEELSTAKATLVCTITDFYPGVVTVDWKVDGTPVTAGMETTQPSKQSNNKYMASSYLTL 183 Query: 648 -----NNNGTYACFVSNLATGRNNSI 668 + +Y+C V++ N ++ Sbjct: 184 TARAWERHSSYSCQVTHEGHSSNKTL 209 Score = 38.4 bits (87), Expect = 0.011, Method: Composition-based stats. Identities = 26/201 (12%), Positives = 49/201 (24%), Gaps = 40/201 (19%) Query: 416 DDPTISPSYTYYRPGVNLSLSCHAAS----------------------------NPPAQY 447 D S PG ++L+C +++ N Sbjct: 1 DAVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRAPGV 60 Query: 448 SWLIDGNIQQHTQELFISNITEKNSGLYTCQA-NNSASGHSRTTVKTITVSAELPKPSIS 506 G++ L I+ ++ +Y C +N+ T T+ + Sbjct: 61 PARFSGSLIGDKAALTITGAQTEDEAIYFCALWSNNKLVFGGGTKLTVLGQPKSSPTVTL 120 Query: 507 SNNSKPVEDKDAVAFTCEPEAQNTTYL---WWVNGQSLP--VSPRLQLSNGNRT------ 555 S C + W V+G + + N Sbjct: 121 FPPSSEELSTAKATLVCTITDFYPGVVTVDWKVDGTPVTAGMETTQPSKQSNNKYMASSY 180 Query: 556 LTLFNVTRNDARAYVCGIQNS 576 LTL +Y C + + Sbjct: 181 LTLTARAWERHSSYSCQVTHE 201 Score = 32.6 bits (72), Expect = 0.66, Method: Composition-based stats. Identities = 30/204 (14%), Positives = 56/204 (27%), Gaps = 46/204 (22%) Query: 238 DAPTISPLNTSYRSGENLNLSCHAA----------------------------SNPPAQY 269 DA + GE + L+C ++ +N Sbjct: 1 DAVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRAPGV 60 Query: 270 SWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEP---PKPF 326 +G+ L I + Y C S+ L T +TV +P P Sbjct: 61 PARFSGSLIGDKAALTITGAQTEDEAIYFCALW-SNNKLVFGGGTKLTVLGQPKSSPTVT 119 Query: 327 ITSNNSNPVEDEDAVALTCEPE--IQNTTYLWWVNNQSLPVSPRLQLSND---------- 374 + +S + L C + W + PV+ ++ + Sbjct: 120 LFPPSSEELSTAK-ATLVCTITDFYPGVVTVDWKVDG-TPVTAGMETTQPSKQSNNKYMA 177 Query: 375 NRTLTLLSVTRNDVGPYECGIQNK 398 + LTL + Y C + ++ Sbjct: 178 SSYLTLTARAWERHSSYSCQVTHE 201 >1D5B-A nrPDB Length = 211 Score = 46.5 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 32/198 (16%), Positives = 59/198 (29%), Gaps = 41/198 (20%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQL-------------- 371 S +S + V +TC+ +YL W + SP+ + Sbjct: 4 MTQSPSSMYASLGERVTITCKASQDINSYLNWFQQKP-GKSPKTLIYRTNRLVDGVPSRF 62 Query: 372 ----SNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNV---LYGPDDPTISPSY 424 S + +LT+ S+ D+G Y C ++ L + + P PS Sbjct: 63 SGSGSGQDYSLTISSLEYEDMGIYYCLQYDEFPYTFGSGTKLEIKRTVAAPSVFIFPPSD 122 Query: 425 TYYRPGVNLSLSCHAASNP-PAQYSWLIDGNIQQHT------------------QELFIS 465 + G + P A+ W +D +Q L +S Sbjct: 123 EQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLS 182 Query: 466 NITEKNSGLYTCQANNSA 483 + +Y C+ + Sbjct: 183 KADYEKHKVYACEVTHQG 200 Score = 43.8 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 30/210 (14%), Positives = 58/210 (27%), Gaps = 41/210 (19%) Query: 147 PSISSNNSKPVEDKDAVAFTCEP--------------ETQDATYLWWVNNQSLPVSPRLQ 192 S +S + V TC+ + L + N+ + P Sbjct: 3 KMTQSPSSMYASLGERVTITCKASQDINSYLNWFQQKPGKSPKTLIYRTNRLVDGVPSRF 62 Query: 193 LSNGNR---TLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLN 246 +G+ +LT+ ++ D Y C + L + AP++ P + Sbjct: 63 SGSGSGQDYSLTISSLEYEDMGIYYCLQYDEFPYTFGSGTKLEIKRTVAAPSVFIFPPSD 122 Query: 247 TSYRSGENLNLSCHAASNPP--AQYSWFVNGTFQ------------------QSTQELFI 286 +SG ++ C + P A+ W V+ Q + L + Sbjct: 123 EQLKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTL 181 Query: 287 PNITVNNSGSYTCQAHNSDTGLNRTTVTTI 316 Y C+ + T Sbjct: 182 SKADYEKHKVYACEVTHQGLSSPVTKSFNR 211 Score = 42.6 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 29/204 (14%), Positives = 62/204 (30%), Gaps = 24/204 (11%) Query: 506 SSNNSKPVEDKDAVAFTCEP--------------EAQNTTYLWWVNG---QSLPVSPRLQ 548 S +S + V TC+ ++ L + +P Sbjct: 6 QSPSSMYASLGERVTITCKASQDINSYLNWFQQKPGKSPKTLIYRTNRLVDGVPSRFSGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVL--YGPDTPIISPPDSSYL 606 S + +LT+ ++ D Y C + L++ + I PP L Sbjct: 66 GSGQDYSLTISSLEYEDMGIYYCLQYDEFPYTFGSGTKLEIKRTVAAPSVFIFPPSDEQL 125 Query: 607 SGANLNLSCHSASNPS--PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGR 664 ++ C + + W+++ Q + + ++ TY+ + + Sbjct: 126 KSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTLSKA 184 Query: 665 NNSIVKSITVSASGTSPGLSAGAT 688 + K + T GLS+ T Sbjct: 185 DYEKHKVY--ACEVTHQGLSSPVT 206 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 31/196 (15%), Positives = 65/196 (33%), Gaps = 39/196 (19%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQYSW------------------LIDGNIQQHT- 459 T SPS Y G ++++C A+ + + +W L+DG + + Sbjct: 5 TQSPSSMYASLGERVTITCKASQDINSYLNWFQQKPGKSPKTLIYRTNRLVDGVPSRFSG 64 Query: 460 ------QELFISNITEKNSGLYTCQANNSASGHSRT-TVKTITVSAELPKPSISSNNSKP 512 L IS++ ++ G+Y C + + T I + P I + + Sbjct: 65 SGSGQDYSLTISSLEYEDMGIYYCLQYDEFPYTFGSGTKLEIKRTVAAPSVFIFPPSDEQ 124 Query: 513 VEDKDAVAFTCEPEAQNT---TYLWWVNGQSLPVSPRLQLS---------NGNRTLTLFN 560 ++ + C W V+ + + ++ + + TLTL Sbjct: 125 LKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSK 183 Query: 561 VTRNDARAYVCGIQNS 576 + Y C + + Sbjct: 184 ADYEKHKVYACEVTHQ 199 Score = 33.0 bits (73), Expect = 0.46, Method: Composition-based stats. Identities = 31/212 (14%), Positives = 59/212 (27%), Gaps = 20/212 (9%) Query: 34 AKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGP 93 K+T + + G+ V + +W++ + + +I P Sbjct: 2 IKMTQSPSSMYASLGERVTITCKASQDINSYLNWFQQKPGKSPKTLIYRTNRLVDGVPS- 60 Query: 94 AYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVN--EEATGQFRVYPELPKPSISS 151 +SG + SL I ++ D G Y + + P I Sbjct: 61 RFSGSG-SGQDYSLTISSLEYEDMGIYYCLQYDEFPYTFGSGTKLEIKRTVAAPSVFIFP 119 Query: 152 NNSKPVEDKDAVAFTCEPETQD--ATYLWWVNN---------QSLPVSPRLQLSNGNRTL 200 + + ++ A A W V+N + + + TL Sbjct: 120 PSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTL 179 Query: 201 TLFNVTRNDTASYKCETQ-----NPVSARRSD 227 TL Y CE +PV+ + Sbjct: 180 TLSKADYEKHKVYACEVTHQGLSSPVTKSFNR 211 >2F58-L nrPDB Length = 216 Score = 46.5 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 33/207 (15%), Positives = 58/207 (28%), Gaps = 45/207 (21%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQ----NTTYLWWVNNQSLPVSPRLQL--------- 371 S S V ++C+ +++ W + L Sbjct: 3 VLTQSPASLAVSLGQRATISCKASQGVDFDGASFMNWYQQKPGQPPKLLIFAASTLESGI 62 Query: 372 --------SNDNRTLTLLSVTRNDVGPYEC--GIQNKLSVDHSDPVILN-VLYGPDDPTI 420 S + TL + V D Y C ++ L+ + L P Sbjct: 63 PARFSGRGSGTDFTLNIHPVEEEDAATYYCQQSHEDPLTFGAGTKLELKRADAAPTVSIF 122 Query: 421 SPSYTYYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQ 460 PS G S+ C + P + W IDG+ +Q+ + Sbjct: 123 PPSSEQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSS 181 Query: 461 ELFISNITEKNSGLYTCQANNSASGHS 487 L ++ + YTC+A + S Sbjct: 182 TLTLTKDEYERHNSYTCEATHKTSTSP 208 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 34/208 (16%), Positives = 55/208 (26%), Gaps = 53/208 (25%) Query: 241 TISPLNTSYRSGENLNLSCHAA------------------SNPPAQYSW----------- 271 T SP + + G+ +SC A+ PP + Sbjct: 5 TQSPASLAVSLGQRATISCKASQGVDFDGASFMNWYQQKPGQPPKLLIFAASTLESGIPA 64 Query: 272 FVNGTFQQSTQELFIPNITVNNSGSYTCQAHN-SDTGLNRTTVTTITVYAEPPKPFITSN 330 +G + L I + ++ +Y CQ + T + P I Sbjct: 65 RFSGRGSGTDFTLNIHPVEEEDAATYYCQQSHEDPLTFGAGTKLELKRADAAPTVSIFPP 124 Query: 331 NSNPVEDEDAVALTC-----------------EPEIQNTTYLWWVNNQSLPVSPRLQLSN 373 +S + ++ C E QN L +Q S Sbjct: 125 SSEQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGV-LNSWTDQDSKDSTYSM--- 179 Query: 374 DNRTLTLLSVTRNDVGPYECGIQNKLSV 401 + TLTL Y C +K S Sbjct: 180 -SSTLTLTKDEYERHNSYTCEATHKTST 206 Score = 38.0 bits (86), Expect = 0.013, Method: Composition-based stats. Identities = 30/166 (18%), Positives = 54/166 (32%), Gaps = 27/166 (16%) Query: 170 ETQDATYLWWVN---NQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRS 226 Q L + +P + S + TL + V D A+Y C+ + Sbjct: 44 PGQPPKLLIFAASTLESGIPARFSGRGSGTDFTLNIHPVEEEDAATYYCQQSHEDPLTFG 103 Query: 227 DSVILNVLYGPDAPTIS---PLNTSYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS- 280 L + APT+S P + SG ++ C + P W ++G+ +Q+ Sbjct: 104 AGTKLELKRADAAPTVSIFPPSSEQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNG 162 Query: 281 -----------------TQELFIPNITVNNSGSYTCQAHNSDTGLN 309 + L + SYTC+A + + Sbjct: 163 VLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSP 208 >1OLZ-A nrPDB Length = 663 Score = 46.1 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 23/115 (20%), Positives = 40/115 (34%), Gaps = 8/115 (6%) Query: 121 TLHV-----IKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDAT 175 T S + +E +G V P+ K S + K C ++ A Sbjct: 507 TCVALHQTESPSRGLIQEMSGDASVCPDKSKGSYRQHFFK---HGGTAELKCSQKSNLAR 563 Query: 176 YLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVI 230 W N L G + L +FN++ D+ Y+C ++ V + V+ Sbjct: 564 VFWKFQNGVLKAESPKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVV 618 Score = 46.1 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 25/115 (21%), Positives = 42/115 (36%), Gaps = 3/115 (2%) Query: 474 LYTCQANNSASGHSRTTVKTITVSAEL-PKPSISSNNSKPVEDKDAVAFTCEPEAQNTTY 532 TC A + SR ++ ++ A + P S S + C ++ Sbjct: 505 TATCVALHQTESPSRGLIQEMSGDASVCPDKSKGSYRQHFFKHGGTAELKCSQKSNLARV 564 Query: 533 LW-WVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVT 586 W + NG SP+ L G + L +FN++ D+ Y C + V V Sbjct: 565 FWKFQNGVLKAESPKYGLM-GRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVV 618 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 21/120 (17%), Positives = 39/120 (32%), Gaps = 17/120 (14%) Query: 392 ECGIQNKLSVDHS---DPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYS 448 C ++ + + PD S +++ G L C SN + Sbjct: 507 TCVALHQTESPSRGLIQEMSGDASVCPDKSKGSYRQHFFKHGGTAELKCSQKSNLARVFW 566 Query: 449 WLIDGNIQQH--------TQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAEL 500 +G ++ + L I N++E +SG+Y C + R KT+ Sbjct: 567 KFQNGVLKAESPKYGLMGRKNLLIFNLSEGDSGVYQCLSE------ERVKNKTVFQVVAK 620 Score = 37.6 bits (85), Expect = 0.019, Method: Composition-based stats. Identities = 28/149 (18%), Positives = 47/149 (31%), Gaps = 19/149 (12%) Query: 570 VCGIQNSVSANRSDPVTL---DVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYS 626 C + + + D PD S + G L C SN + Sbjct: 507 TCVALHQTESPSRGLIQEMSGDASVCPDKSKGSYRQHFFKHGGTAELKCSQKSN-LARVF 565 Query: 627 WRI-NGIPQQHT--------QVLFIAKITPNNNGTYACFVSNLATGRN------NSIVKS 671 W+ NG+ + + + L I ++ ++G Y C + +++ Sbjct: 566 WKFQNGVLKAESPKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVVAKHVLEV 625 Query: 672 ITVSASGTSPGLSAGATVGIMIGVLVGVA 700 V +P LS T G I V VA Sbjct: 626 KVVPKPVVAPTLSVVQTEGSRIATKVLVA 654 Score = 33.0 bits (73), Expect = 0.46, Method: Composition-based stats. Identities = 22/105 (20%), Positives = 38/105 (36%), Gaps = 12/105 (11%) Query: 249 YRSGENLNLSCHAASNPPAQYSW-FVNGTFQQS--------TQELFIPNITVNNSGSYTC 299 ++ G L C SN A+ W F NG + + L I N++ +SG Y C Sbjct: 545 FKHGGTAELKCSQKSN-LARVFWKFQNGVLKAESPKYGLMGRKNLLIFNLSEGDSGVYQC 603 Query: 300 --QAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVA 342 + + + + + PKP + S + +A Sbjct: 604 LSEERVKNKTVFQVVAKHVLEVKVVPKPVVAPTLSVVQTEGSRIA 648 Score = 32.2 bits (71), Expect = 0.88, Method: Composition-based stats. Identities = 18/113 (15%), Positives = 36/113 (31%), Gaps = 3/113 (2%) Query: 298 TCQAHNSDTGLNRTTVTTIT--VYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYL 355 TC A + +R + ++ P K S + + L C + Sbjct: 507 TCVALHQTESPSRGLIQEMSGDASVCPDKSK-GSYRQHFFKHGGTAELKCSQKSNLARVF 565 Query: 356 WWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVI 408 W N L + L + +++ D G Y+C + ++ V+ Sbjct: 566 WKFQNGVLKAESPKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVV 618 >1EMT-L nrPDB Length = 214 Score = 45.7 bits (106), Expect = 7e-05, Method: Composition-based stats. Identities = 34/201 (16%), Positives = 62/201 (30%), Gaps = 39/201 (19%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRL---------------- 369 + +S D V +C + YL W + L Sbjct: 4 MTQTTSSLSASLGDRVTFSCSASQDISNYLNWYQQKPDGTIKLLIYYTSSLRSGVPSRFS 63 Query: 370 -QLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYTY 426 S + +LT+ ++ D+ Y C ++L L + PT+S P + Sbjct: 64 GSGSGTDYSLTINNLEPEDIATYFCQQYSRLPFTFGSGTKLEIKRADAAPTVSIFPPSSE 123 Query: 427 YRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFISN 466 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 124 QLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 183 Query: 467 ITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 184 DEYERHNSYTCEATHKTSTSP 204 Score = 43.8 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 36/201 (17%), Positives = 66/201 (32%), Gaps = 41/201 (20%) Query: 149 ISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRL 191 + +S D V F+C + YL W + +P Sbjct: 5 TQTTSSLSASLGDRVTFSCSASQDISNYLNWYQQKPDGTIKLLIYYTSSLRSGVPSRFSG 64 Query: 192 QLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTS 248 S + +LT+ N+ D A+Y C+ + + L + APT+S P + Sbjct: 65 SGSGTDYSLTINNLEPEDIATYFCQQYSRLPFTFGSGTKLEIKRADAAPTVSIFPPSSEQ 124 Query: 249 YRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFIPN 288 SG ++ C + P W ++G+ +Q+ + L + Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 183 Query: 289 ITVNNSGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 184 DEYERHNSYTCEATHKTSTSP 204 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 31/198 (15%), Positives = 61/198 (30%), Gaps = 39/198 (19%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTY-LWWVNG----------------QSLPVSPRLQ 548 + +S D V F+C + Y W+ +P Sbjct: 6 QTTSSLSASLGDRVTFSCSASQDISNYLNWYQQKPDGTIKLLIYYTSSLRSGVPSRFSGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSYL 606 S + +LT+ N+ D Y C + + L++ P +S PP S L Sbjct: 66 GSGTDYSLTINNLEPEDIATYFCQQYSRLPFTFGSGTKLEIKRADAAPTVSIFPPSSEQL 125 Query: 607 SGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKIT 646 + ++ C + + W+I+G +Q+ L + K Sbjct: 126 TSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDE 185 Query: 647 PNNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 YERHNSYTCEATHKTSTS 203 Score = 34.5 bits (77), Expect = 0.17, Method: Composition-based stats. Identities = 34/204 (16%), Positives = 55/204 (26%), Gaps = 49/204 (24%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T + + S G+ + SC A+ + +W+ G Sbjct: 5 TQTTSSLSASLGDRVTFSCSASQDISNYLNWYQQKPDGTIKLLIYYTSSLRSGVPSRFSG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQAH-NSDTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 + + L I N+ + +Y CQ + T I P I +S Sbjct: 65 SGSGTDYSLTINNLEPEDIATYFCQQYSRLPFTFGSGTKLEIKRADAAPTVSIFPPSSEQ 124 Query: 335 VEDEDAVALTC-----------------EPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRT 377 + ++ C E QN L +Q S + T Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGV-LNSWTDQDSKDSTYSM----SST 178 Query: 378 LTLLSVTRNDVGPYECGIQNKLSV 401 LTL Y C +K S Sbjct: 179 LTLTKDEYERHNSYTCEATHKTST 202 Score = 33.0 bits (73), Expect = 0.43, Method: Composition-based stats. Identities = 33/201 (16%), Positives = 64/201 (31%), Gaps = 19/201 (9%) Query: 37 TIESTPFNVAEGKEVLLLVHNLPQHLFGY-SWYKGERVDGNRQIIGYVIGTQQATPGPAY 95 T S ++ + + Q + Y +WY+ ++ DG +++ Y + ++ + Sbjct: 7 TTSSLSASLGDRVTFSC---SASQDISNYLNWYQ-QKPDGTIKLLIYYTSSLRSGVPSRF 62 Query: 96 SGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSIS----S 151 SG + SL I N+ D Y + + + P++S S Sbjct: 63 SGSGSGT-DYSLTINNLEPEDIATYFCQQYSRLPFTFGSGTKLEIKRADAAPTVSIFPPS 121 Query: 152 NNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS---------LPVSPRLQLSNGNRTLTL 202 + V F +D W ++ + + + TLTL Sbjct: 122 SEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTL 181 Query: 203 FNVTRNDTASYKCETQNPVSA 223 SY CE + S Sbjct: 182 TKDEYERHNSYTCEATHKTST 202 >6FAB-L nrPDB Length = 214 Score = 45.7 bits (106), Expect = 8e-05, Method: Composition-based stats. Identities = 34/197 (17%), Positives = 62/197 (31%), Gaps = 39/197 (19%) Query: 330 NNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRL-----------------QLS 372 +S D V+++C +L W + L S Sbjct: 8 PSSLSASLGDRVSISCRASQDINNFLNWYQQKPDGTIKLLIYFTSRSQSGVPSRFSGSGS 67 Query: 373 NDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYTYYRPG 430 + +LT+ ++ + D+ Y C N L L + PT+S P + Sbjct: 68 GTDYSLTISNLEQEDIATYFCQQGNALPRTFGGGTKLEIKRADAAPTVSIFPPSSEQLTS 127 Query: 431 VNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFISNITEK 470 S+ C + P + W IDG+ +Q+ + L ++ + Sbjct: 128 GGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYE 187 Query: 471 NSGLYTCQANNSASGHS 487 YTC+A + S Sbjct: 188 RHNSYTCEATHKTSTSP 204 Score = 42.2 bits (97), Expect = 8e-04, Method: Composition-based stats. Identities = 31/198 (15%), Positives = 61/198 (30%), Gaps = 39/198 (19%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQ-NTTYLWWVNG----------------QSLPVSPRLQ 548 +S D V+ +C N W+ +P Sbjct: 6 QIPSSLSASLGDRVSISCRASQDINNFLNWYQQKPDGTIKLLIYFTSRSQSGVPSRFSGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSYL 606 S + +LT+ N+ + D Y C N++ L++ P +S PP S L Sbjct: 66 GSGTDYSLTISNLEQEDIATYFCQQGNALPRTFGGGTKLEIKRADAAPTVSIFPPSSEQL 125 Query: 607 SGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKIT 646 + ++ C + + W+I+G +Q+ L + K Sbjct: 126 TSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDE 185 Query: 647 PNNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 YERHNSYTCEATHKTSTS 203 Score = 41.8 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 35/197 (17%), Positives = 65/197 (32%), Gaps = 41/197 (20%) Query: 153 NSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRLQLSN 195 +S D V+ +C +L W + +P S Sbjct: 9 SSLSASLGDRVSISCRASQDINNFLNWYQQKPDGTIKLLIYFTSRSQSGVPSRFSGSGSG 68 Query: 196 GNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTSYRSG 252 + +LT+ N+ + D A+Y C+ N + L + APT+S P + SG Sbjct: 69 TDYSLTISNLEQEDIATYFCQQGNALPRTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSG 128 Query: 253 ENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFIPNITVN 292 ++ C + P W ++G+ +Q+ + L + Sbjct: 129 -GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYE 187 Query: 293 NSGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 188 RHNSYTCEATHKTSTSP 204 Score = 38.4 bits (87), Expect = 0.011, Method: Composition-based stats. Identities = 35/195 (17%), Positives = 58/195 (29%), Gaps = 39/195 (20%) Query: 422 PSYTYYRPGVNLSLSCHAASNPPAQYSW---LIDGNIQQH-------------------- 458 PS G +S+SC A+ + +W DG I+ Sbjct: 8 PSSLSASLGDRVSISCRASQDINNFLNWYQQKPDGTIKLLIYFTSRSQSGVPSRFSGSGS 67 Query: 459 --TQELFISNITEKNSGLYTCQANNSA-SGHSRTTVKTITVSAELPKPSISSNNSKPVED 515 L ISN+ +++ Y CQ N+ T I + P SI +S+ + Sbjct: 68 GTDYSLTISNLEQEDIATYFCQQGNALPRTFGGGTKLEIKRADAAPTVSIFPPSSEQLTS 127 Query: 516 KDAVAFTCEPEAQNTT---YLWWVNGQSLPV---------SPRLQLSNGNRTLTLFNVTR 563 + C W ++G + + + TLTL Sbjct: 128 G-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEY 186 Query: 564 NDARAYVCGIQNSVS 578 +Y C + S Sbjct: 187 ERHNSYTCEATHKTS 201 Score = 36.5 bits (82), Expect = 0.037, Method: Composition-based stats. Identities = 31/171 (18%), Positives = 55/171 (32%), Gaps = 15/171 (8%) Query: 66 SWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVI 125 +WY+ ++ DG +++ Y Q+ +SG + SL I N+ Q D Y Sbjct: 34 NWYQ-QKPDGTIKLLIYFTSRSQSGVPSRFSGSGSGT-DYSLTISNLEQEDIATYFCQQG 91 Query: 126 KSDLVNEEATGQFRVYPELPKPSIS----SNNSKPVEDKDAVAFTCEPETQDATYLWWVN 181 + + + P++S S+ V F +D W ++ Sbjct: 92 NALPRTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKID 151 Query: 182 NQS---------LPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSA 223 + + + TLTL SY CE + S Sbjct: 152 GSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTST 202 >1MH5-A nrPDB Length = 219 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 39/201 (19%), Positives = 65/201 (32%), Gaps = 46/201 (22%) Query: 332 SNPVEDEDAVALTCEP-----EIQNTTYLWWVNNQSLPVSPRLQL--------------- 371 S V ++V+++C TYL+W + SP+L + Sbjct: 10 SVSVTPGESVSISCRSSKSLLHSNGNTYLYWFLQRP-GQSPQLLIYRMSNLASGVPDRFS 68 Query: 372 ---SNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYTY 426 S TL + V DVG Y C + L + PT+S P + Sbjct: 69 GSGSGTAFTLRISRVEAEDVGVYYCLQHLEYPFTFGAGTKLELKRADAAPTVSIFPPSSE 128 Query: 427 YRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFISN 466 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 129 QLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 188 Query: 467 ITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 189 DEYERHNSYTCEATHKTSTSP 209 Score = 41.1 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 29/168 (17%), Positives = 51/168 (30%), Gaps = 27/168 (16%) Query: 168 EPETQDATYLWWVNNQSLPVSPRLQLSNGNRT---LTLFNVTRNDTASYKCETQNPVSAR 224 + Q L + + P +G+ T L + V D Y C Sbjct: 43 QRPGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLRISRVEAEDVGVYYCLQHLEYPFT 102 Query: 225 RSDSVILNVLYGPDAPTIS---PLNTSYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQ 279 L + APT+S P + SG ++ C + P W ++G+ +Q Sbjct: 103 FGAGTKLELKRADAAPTVSIFPPSSEQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQ 161 Query: 280 S------------------TQELFIPNITVNNSGSYTCQAHNSDTGLN 309 + + L + SYTC+A + + Sbjct: 162 NGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSP 209 Score = 38.0 bits (86), Expect = 0.016, Method: Composition-based stats. Identities = 30/203 (14%), Positives = 58/203 (28%), Gaps = 44/203 (21%) Query: 506 SSNNSKPVEDKDAVAFTCEP-------------------EAQNTTYLWWVNGQ---SLPV 543 + S V ++V+ +C Q+ L + +P Sbjct: 6 QAAPSVSVTPGESVSISCRSSKSLLHSNGNTYLYWFLQRPGQSPQLLIYRMSNLASGVPD 65 Query: 544 SPRLQLSNGNRTLTLFNVTRNDARAYVCG--IQNSVSANRSDPVTLDVLYGPDTPIISPP 601 S TL + V D Y C ++ + + L T I PP Sbjct: 66 RFSGSGSGTAFTLRISRVEAEDVGVYYCLQHLEYPFTFGAGTKLELKRADAAPTVSIFPP 125 Query: 602 DSSYLSGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLF 641 S L+ ++ C + + W+I+G +Q+ L Sbjct: 126 SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLT 185 Query: 642 IAKITPNNNGTYACFVSNLATGR 664 + K + +Y C ++ + Sbjct: 186 LTKDEYERHNSYTCEATHKTSTS 208 >1IAI-M nrPDB Length = 215 Score = 44.9 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 35/202 (17%), Positives = 62/202 (30%), Gaps = 40/202 (19%) Query: 326 FITSNNSNPVEDEDAVALTC----------------EPEIQNTTYLWWVNNQ--SLPVSP 367 S + V +TC + E +++ +N +PV Sbjct: 4 LTQSPAFMAASPGEKVTITCSVSSSISSSNLHWYQQKSETSPKPWIYGTSNLASGVPVRF 63 Query: 368 RLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYT 425 S + +LT+ S+ D Y C N L + PT+S P + Sbjct: 64 SGSGSGTSYSLTISSMEAEDAATYYCQQWNSYPYTFGGGTKLEIKRADAAPTVSIFPPSS 123 Query: 426 YYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFIS 465 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 124 EQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLT 183 Query: 466 NITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 184 KDEYERHNSYTCEATHKTSTSP 205 Score = 36.8 bits (83), Expect = 0.033, Method: Composition-based stats. Identities = 32/165 (19%), Positives = 60/165 (36%), Gaps = 26/165 (15%) Query: 170 ETQDATYLWWVNN--QSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSD 227 ET +++ +N +PV S + +LT+ ++ D A+Y C+ N Sbjct: 42 ETSPKPWIYGTSNLASGVPVRFSGSGSGTSYSLTISSMEAEDAATYYCQQWNSYPYTFGG 101 Query: 228 SVILNVLYGPDAPTIS---PLNTSYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS-- 280 L + APT+S P + SG ++ C + P W ++G+ +Q+ Sbjct: 102 GTKLEIKRADAAPTVSIFPPSSEQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGV 160 Query: 281 ----------------TQELFIPNITVNNSGSYTCQAHNSDTGLN 309 + L + SYTC+A + + Sbjct: 161 LNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSP 205 Score = 34.5 bits (77), Expect = 0.16, Method: Composition-based stats. Identities = 36/205 (17%), Positives = 58/205 (28%), Gaps = 50/205 (24%) Query: 241 TISPLNTSYRSGENLNLSC----------------HAASNPPAQYSWFVN---------- 274 T SP + GE + ++C + ++P N Sbjct: 5 TQSPAFMAASPGEKVTITCSVSSSISSSNLHWYQQKSETSPKPWIYGTSNLASGVPVRFS 64 Query: 275 GTFQQSTQELFIPNITVNNSGSYTCQAHNS-DTGLNRTTVTTITVYAEPPKPFITSNNSN 333 G+ ++ L I ++ ++ +Y CQ NS T I P I +S Sbjct: 65 GSGSGTSYSLTISSMEAEDAATYYCQQWNSYPYTFGGGTKLEIKRADAAPTVSIFPPSSE 124 Query: 334 PVEDEDAVALTC-----------------EPEIQNTTYLWWVNNQSLPVSPRLQLSNDNR 376 + ++ C E QN L +Q S + Sbjct: 125 QLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGV-LNSWTDQDSKDSTYSM----SS 178 Query: 377 TLTLLSVTRNDVGPYECGIQNKLSV 401 TLTL Y C +K S Sbjct: 179 TLTLTKDEYERHNSYTCEATHKTST 203 Score = 33.8 bits (75), Expect = 0.30, Method: Composition-based stats. Identities = 32/199 (16%), Positives = 61/199 (30%), Gaps = 40/199 (20%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTYL--WWVNGQS----------------LPVSPRL 547 S + V TC + ++ W+ +PV Sbjct: 6 QSPAFMAASPGEKVTITCSVSSSISSSNLHWYQQKSETSPKPWIYGTSNLASGVPVRFSG 65 Query: 548 QLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSY 605 S + +LT+ ++ DA Y C NS L++ P +S PP S Sbjct: 66 SGSGTSYSLTISSMEAEDAATYYCQQWNSYPYTFGGGTKLEIKRADAAPTVSIFPPSSEQ 125 Query: 606 LSGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKI 645 L+ ++ C + + W+I+G +Q+ L + K Sbjct: 126 LTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKD 185 Query: 646 TPNNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 EYERHNSYTCEATHKTSTS 204 >4BFE-A nrPDB Length = 221 Score = 44.5 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 30/143 (20%), Positives = 46/143 (32%), Gaps = 21/143 (14%) Query: 548 QLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLS 607 + + L + V Y C I N L VL P+ +Y Sbjct: 81 STPDHSPELQISAVALQHEGTYTCEIVTPEG-NLEKVYDLQVLVPPEV--------TYFP 131 Query: 608 GANLNLSCHS-ASNPSPQYSWRINGI-----PQQHTQVLFIAKI---TPNNNGTYACFVS 658 G N C + A P+ Q SW +G + + NN +C VS Sbjct: 132 GKNRTAVCEAMAGKPAAQISWTPDGDCVTKSESHSNGTVTVRSTCHWEQNNVSVVSCLVS 191 Query: 659 NLATGRNNSIVKSITVSASGTSP 681 + ++ SI S + T+P Sbjct: 192 HSTGNQSLSIELS---QGTMTTP 211 Score = 42.6 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 26/136 (19%), Positives = 45/136 (33%), Gaps = 21/136 (15%) Query: 457 QHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDK 516 H+ EL IS + ++ G YTC+ + + V E+ Sbjct: 84 DHSPELQISAVALQHEGTYTCEIVTPEGNLEKVYDLQVLVPPEV-----------TYFPG 132 Query: 517 DAVAFTCEPEAQNTT--YLWWVNGQSLPVSPRLQLSNGNRTLTLFNV---TRNDARAYVC 571 CE A W +G + S N T+T+ + +N+ C Sbjct: 133 KNRTAVCEAMAGKPAAQISWTPDGDCVTKSESHS----NGTVTVRSTCHWEQNNVSVVSC 188 Query: 572 GIQNSVSANRSDPVTL 587 + +S N+S + L Sbjct: 189 LVSHSTG-NQSLSIEL 203 Score = 39.9 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 21/77 (27%), Positives = 28/77 (36%), Gaps = 10/77 (12%) Query: 200 LTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSC 259 L + V +Y CE P N+ D + P +Y G+N C Sbjct: 89 LQISAVALQHEGTYTCEIVTP---------EGNLEKVYDLQVLVPPEVTYFPGKNRTAVC 139 Query: 260 HA-ASNPPAQYSWFVNG 275 A A P AQ SW +G Sbjct: 140 EAMAGKPAAQISWTPDG 156 Score = 38.4 bits (87), Expect = 0.012, Method: Composition-based stats. Identities = 17/101 (16%), Positives = 29/101 (28%), Gaps = 11/101 (10%) Query: 279 QSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDE 338 + EL I + + + G+YTC+ + L + V + V P + Sbjct: 84 DHSPELQISAVALQHEGTYTCEIVTPEGNLEK--VYDLQVLVPPEVTYF---------PG 132 Query: 339 DAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLT 379 CE V+ SN T+ Sbjct: 133 KNRTAVCEAMAGKPAAQISWTPDGDCVTKSESHSNGTVTVR 173 Score = 38.0 bits (86), Expect = 0.013, Method: Composition-based stats. Identities = 34/165 (20%), Positives = 49/165 (29%), Gaps = 32/165 (19%) Query: 312 TVTTITVYAEPPKPFITSNNSNPVEDEDAVALTC--EPEIQNTTYLWWVNNQSLPVSP-- 367 T T+ + N + V+ + L C P I W + ++ LP Sbjct: 1 TDENQTIQNDSSSSLTQVNTTMSVQMDKKALLCCFSSPLINAVLITWIIKHRHLPSCTIA 60 Query: 368 ------------------RLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVIL 409 + + L + +V G Y C I Sbjct: 61 YNLDKKTNETSCLGRNITWASTPDHSPELQISAVALQHEGTYTCEIVTPEG--------- 111 Query: 410 NVLYGPDDPTISPSYTYYRPGVNLSLSCHA-ASNPPAQYSWLIDG 453 N+ D + P Y PG N + C A A P AQ SW DG Sbjct: 112 NLEKVYDLQVLVPPEVTYFPGKNRTAVCEAMAGKPAAQISWTPDG 156 >4BFG-A nrPDB Length = 216 Score = 44.5 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 35/205 (17%), Positives = 63/205 (30%), Gaps = 25/205 (12%) Query: 480 NNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQ 539 + S T TVS ++ ++ S P+ + + + + + + Sbjct: 6 TTQNNSSSPLTQVNTTVSVQIGTKALLCCFSIPLTKAVLITWIIKLRGLPSCTIAYKVDT 65 Query: 540 SLPVSPRL-------QLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYG 592 + L + + L + VT Y C N L VL Sbjct: 66 KTNETSCLGRNITWASTPDHSPELQISAVTLQHEGTYTCETVTPEG-NFEKNYDLQVLVP 124 Query: 593 PDTPIISPPDSSYLSGANLNLSCHS-ASNPSPQYSWRINGI-----PQQHTQVLFIAKI- 645 P+ +Y N + C + A P+ Q SW +G + + Sbjct: 125 PEV--------TYFPEKNRSAVCEAMAGKPAAQISWSPDGDCVTTSESHSNGTVTVRSTC 176 Query: 646 --TPNNNGTYACFVSNLATGRNNSI 668 NN +C VS+L ++ SI Sbjct: 177 HWEQNNVSDVSCIVSHLTGNQSLSI 201 Score = 40.7 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 28/136 (20%), Positives = 47/136 (34%), Gaps = 21/136 (15%) Query: 457 QHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDK 516 H+ EL IS +T ++ G YTC+ + + V E+ N V Sbjct: 84 DHSPELQISAVTLQHEGTYTCETVTPEGNFEKNYDLQVLVPPEVTY--FPEKNRSAV--- 138 Query: 517 DAVAFTCEPEAQNTT--YLWWVNGQSLPVSPRLQLSNGNRTLTLFNV---TRNDARAYVC 571 CE A W +G + S N T+T+ + +N+ C Sbjct: 139 ------CEAMAGKPAAQISWSPDGDCVTTSESHS----NGTVTVRSTCHWEQNNVSDVSC 188 Query: 572 GIQNSVSANRSDPVTL 587 + + N+S + L Sbjct: 189 IVSHLTG-NQSLSIEL 203 Score = 38.4 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 29/119 (24%), Positives = 46/119 (38%), Gaps = 14/119 (11%) Query: 200 LTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSC 259 L + VT +Y CET P + L VL P+ +Y +N + C Sbjct: 89 LQISAVTLQHEGTYTCETVTPEG-NFEKNYDLQVLVPPE--------VTYFPEKNRSAVC 139 Query: 260 HA-ASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTIT 317 A A P AQ SW +G +++ +TV + TC ++ V+ +T Sbjct: 140 EAMAGKPAAQISWSPDGDCVTTSESHSNGTVTVRS----TCHWEQNNVSDVSCIVSHLT 194 Score = 36.5 bits (82), Expect = 0.038, Method: Composition-based stats. Identities = 17/101 (16%), Positives = 31/101 (30%), Gaps = 11/101 (10%) Query: 279 QSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDE 338 + EL I +T+ + G+YTC+ + + + V PP+ Sbjct: 84 DHSPELQISAVTLQHEGTYTCETVTPEGNFEKNYDLQVLV---PPEVTYFPE-------- 132 Query: 339 DAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLT 379 + CE + V+ SN T+ Sbjct: 133 KNRSAVCEAMAGKPAAQISWSPDGDCVTTSESHSNGTVTVR 173 Score = 35.7 bits (80), Expect = 0.072, Method: Composition-based stats. Identities = 35/165 (21%), Positives = 46/165 (27%), Gaps = 32/165 (19%) Query: 312 TVTTITVYAEPPKPFITSNNSNPVEDEDAVALTC--EPEIQNTTYLWWVNNQSLPVSP-- 367 T T P N + V+ L C P + W + + LP Sbjct: 1 TDKNQTTQNNSSSPLTQVNTTVSVQIGTKALLCCFSIPLTKAVLITWIIKLRGLPSCTIA 60 Query: 368 ------------------RLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVIL 409 + + L + +VT G Y C + L Sbjct: 61 YKVDTKTNETSCLGRNITWASTPDHSPELQISAVTLQHEGTYTCETV-TPEGNFEKNYDL 119 Query: 410 NVLYGPDDPTISPSYTYYRPGVNLSLSCHA-ASNPPAQYSWLIDG 453 VL P+ Y P N S C A A P AQ SW DG Sbjct: 120 QVLVPPEVT--------YFPEKNRSAVCEAMAGKPAAQISWSPDG 156 >1FBI-L nrPDB Length = 214 Score = 44.5 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 34/201 (16%), Positives = 62/201 (30%), Gaps = 39/201 (19%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRL---------------- 369 + +S D V ++C + YL W + L Sbjct: 4 MTQTTSSLSASLGDRVTISCRASQDISNYLNWYQKKPDGTVKLLIYYTSRLHSGVPSRFS 63 Query: 370 -QLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYTY 426 S + +LT+ ++ + D+ Y C L L + PT+S P + Sbjct: 64 GSGSGTDYSLTIRNLEQEDIATYFCQQGYTLPYTFGGGTKLEIKRADAAPTVSIFPPSSE 123 Query: 427 YRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFISN 466 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 124 QLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 183 Query: 467 ITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 184 DEYERHNSYTCEATHKTSTSP 204 Score = 42.6 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 35/201 (17%), Positives = 65/201 (32%), Gaps = 41/201 (20%) Query: 149 ISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRL 191 + +S D V +C + YL W + +P Sbjct: 5 TQTTSSLSASLGDRVTISCRASQDISNYLNWYQKKPDGTVKLLIYYTSRLHSGVPSRFSG 64 Query: 192 QLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTS 248 S + +LT+ N+ + D A+Y C+ + L + APT+S P + Sbjct: 65 SGSGTDYSLTIRNLEQEDIATYFCQQGYTLPYTFGGGTKLEIKRADAAPTVSIFPPSSEQ 124 Query: 249 YRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFIPN 288 SG ++ C + P W ++G+ +Q+ + L + Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 183 Query: 289 ITVNNSGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 184 DEYERHNSYTCEATHKTSTSP 204 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 30/198 (15%), Positives = 61/198 (30%), Gaps = 39/198 (19%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTY-LWWVNG----------------QSLPVSPRLQ 548 + +S D V +C + Y W+ +P Sbjct: 6 QTTSSLSASLGDRVTISCRASQDISNYLNWYQKKPDGTVKLLIYYTSRLHSGVPSRFSGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSYL 606 S + +LT+ N+ + D Y C ++ L++ P +S PP S L Sbjct: 66 GSGTDYSLTIRNLEQEDIATYFCQQGYTLPYTFGGGTKLEIKRADAAPTVSIFPPSSEQL 125 Query: 607 SGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKIT 646 + ++ C + + W+I+G +Q+ L + K Sbjct: 126 TSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDE 185 Query: 647 PNNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 YERHNSYTCEATHKTSTS 203 Score = 35.7 bits (80), Expect = 0.071, Method: Composition-based stats. Identities = 35/204 (17%), Positives = 58/204 (28%), Gaps = 49/204 (24%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFV---NGTFQ------------------- 278 T + + S G+ + +SC A+ + +W+ +GT + Sbjct: 5 TQTTSSLSASLGDRVTISCRASQDISNYLNWYQKKPDGTVKLLIYYTSRLHSGVPSRFSG 64 Query: 279 ---QSTQELFIPNITVNNSGSYTC-QAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 + L I N+ + +Y C Q + T I P I +S Sbjct: 65 SGSGTDYSLTIRNLEQEDIATYFCQQGYTLPYTFGGGTKLEIKRADAAPTVSIFPPSSEQ 124 Query: 335 VEDEDAVALTC-----------------EPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRT 377 + ++ C E QN L +Q S + T Sbjct: 125 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGV-LNSWTDQDSKDSTYSM----SST 178 Query: 378 LTLLSVTRNDVGPYECGIQNKLSV 401 LTL Y C +K S Sbjct: 179 LTLTKDEYERHNSYTCEATHKTST 202 Score = 34.1 bits (76), Expect = 0.19, Method: Composition-based stats. Identities = 34/201 (16%), Positives = 64/201 (31%), Gaps = 19/201 (9%) Query: 37 TIESTPFNVAEGKEVLLLVHNLPQHLFGY-SWYKGERVDGNRQIIGYVIGTQQATPGPAY 95 T S ++ + + Q + Y +WY+ ++ DG +++ Y + + Sbjct: 7 TTSSLSASLGDRVTISCRAS---QDISNYLNWYQ-KKPDGTVKLLIYYTSRLHSGVPSRF 62 Query: 96 SGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSIS----S 151 SG + SL I+N+ Q D Y + + + P++S S Sbjct: 63 SGSGSGT-DYSLTIRNLEQEDIATYFCQQGYTLPYTFGGGTKLEIKRADAAPTVSIFPPS 121 Query: 152 NNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS---------LPVSPRLQLSNGNRTLTL 202 + V F +D W ++ + + + TLTL Sbjct: 122 SEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTL 181 Query: 203 FNVTRNDTASYKCETQNPVSA 223 SY CE + S Sbjct: 182 TKDEYERHNSYTCEATHKTST 202 >1JN6-A nrPDB Length = 210 Score = 44.2 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 35/206 (16%), Positives = 55/206 (26%), Gaps = 42/206 (20%) Query: 148 SISSNNSKPVEDKDAVAFTCEPETQDATYLWWVN-----------------NQSLPVSPR 190 ++ ++ + V TC + T + N N P P Sbjct: 3 VVTQESALTTSPGETVTLTCRSSSGAITTSHYANWIQEKPDHLFTGLISGTNNRAPGVPA 62 Query: 191 LQ---LSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAP---TISP 244 L LT+ D A Y C + VL P + T+ P Sbjct: 63 RFSGSLIGDKAALTITGAQTEDEAIYICALWFSNQFIFGSGTKVTVLGQPKSSPSVTLFP 122 Query: 245 LNTSYRSGENLNLSCHAASNPPA--QYSWFVNGTFQQSTQELFIPNITVNNS-------- 294 ++ L C P W V+GT E P+ NN Sbjct: 123 PSSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQPSKQSNNKYMASSYLT 182 Query: 295 ---------GSYTCQAHNSDTGLNRT 311 SY+CQ + + ++ Sbjct: 183 LTARAWERHSSYSCQVTHEGHTVEKS 208 Score = 42.2 bits (97), Expect = 8e-04, Method: Composition-based stats. Identities = 27/198 (13%), Positives = 50/198 (25%), Gaps = 40/198 (20%) Query: 419 TISPSYTYYRPGVNLSLSCHAAS----------------------------NPPAQYSWL 450 S PG ++L+C ++S N Sbjct: 4 VTQESALTTSPGETVTLTCRSSSGAITTSHYANWIQEKPDHLFTGLISGTNNRAPGVPAR 63 Query: 451 IDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSIS-SNN 509 G++ L I+ ++ +Y C S + K + PS++ Sbjct: 64 FSGSLIGDKAALTITGAQTEDEAIYICALWFSNQFIFGSGTKVTVLGQPKSSPSVTLFPP 123 Query: 510 SKPVEDKDAVAFTCEPEAQNTTYL---WWVNGQSLPV--SPRLQLSNGNRT------LTL 558 S + + C + W V+G + N LTL Sbjct: 124 SSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQPSKQSNNKYMASSYLTL 183 Query: 559 FNVTRNDARAYVCGIQNS 576 +Y C + + Sbjct: 184 TARAWERHSSYSCQVTHE 201 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 34/209 (16%), Positives = 52/209 (24%), Gaps = 31/209 (14%) Query: 505 ISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVN--------------------GQSLPVS 544 ++ ++ + V TC + T + N +P Sbjct: 4 VTQESALTTSPGETVTLTCRSSSGAITTSHYANWIQEKPDHLFTGLISGTNNRAPGVPAR 63 Query: 545 PRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTP---IISPP 601 L LT+ D Y+C + S + VL P + + PP Sbjct: 64 FSGSLIGDKAALTITGAQTEDEAIYICALWFSNQFIFGSGTKVTVLGQPKSSPSVTLFPP 123 Query: 602 DSSYLSGANLNLSCHSASNPS--PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSN 659 S L L C W+++G P NN Y Sbjct: 124 SSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQPSKQSNNK--YMASSYL 181 Query: 660 LATGRNNSIVKS----ITVSASGTSPGLS 684 T R S +T LS Sbjct: 182 TLTARAWERHSSYSCQVTHEGHTVEKSLS 210 Score = 37.6 bits (85), Expect = 0.018, Method: Composition-based stats. Identities = 28/198 (14%), Positives = 52/198 (26%), Gaps = 44/198 (22%) Query: 243 SPLNTSYRSGENLNLSCHAAS----------------------------NPPAQYSWFVN 274 + GE + L+C ++S N + Sbjct: 6 QESALTTSPGETVTLTCRSSSGAITTSHYANWIQEKPDHLFTGLISGTNNRAPGVPARFS 65 Query: 275 GTFQQSTQELFIPNITVNNSGSYTCQAH--NSDTGLNRTTVTTITVYAEPPKPFITSNNS 332 G+ L I + Y C N + T VT + P + +S Sbjct: 66 GSLIGDKAALTITGAQTEDEAIYICALWFSNQFIFGSGTKVTVLGQPKSSPSVTLFPPSS 125 Query: 333 NPVEDEDAVALTCEPE--IQNTTYLWWVNNQSLPVSPRLQLSND----------NRTLTL 380 +E L C + W + PV+ ++ + + LTL Sbjct: 126 EELETNK-ATLVCTITDFYPGVVTVDWKVDG-TPVTQGMETTQPSKQSNNKYMASSYLTL 183 Query: 381 LSVTRNDVGPYECGIQNK 398 + Y C + ++ Sbjct: 184 TARAWERHSSYSCQVTHE 201 Score = 31.8 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 31/153 (20%), Positives = 51/153 (33%), Gaps = 16/153 (10%) Query: 81 GYVIGTQQATPG-PA-YSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQF 138 G + GT PG PA +SG +I A+L I D Y + S+ + + Sbjct: 48 GLISGTNNRAPGVPARFSGS-LIGDKAALTITGAQTEDEAIYICALWFSNQFIFGSGTKV 106 Query: 139 RVYPE---LPKPSISSNNSKPVEDKDAVAFTCEPETQD--ATYLWWVNNQSL-------- 185 V + P ++ +S+ +E A + T W V+ + Sbjct: 107 TVLGQPKSSPSVTLFPPSSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQ 166 Query: 186 PVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ 218 P + LTL +SY C+ Sbjct: 167 PSKQSNNKYMASSYLTLTARAWERHSSYSCQVT 199 >2QHR-L nrPDB Length = 218 Score = 44.2 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 34/211 (16%), Positives = 68/211 (32%), Gaps = 47/211 (22%) Query: 148 SISSNNSKPVEDKDAVAFTCEPETQDATY--LWWVNNQSLPVSPRLQL------------ 193 ++ ++S + TC Q +TY W+ P ++L Sbjct: 3 VLTQSSSASFSLGASAKLTCTLSRQHSTYTIEWYQQQPLKPPRYVMELKKDGSHSTGDGI 62 Query: 194 --------SNGNRTLTLFNVTRNDTASYKCETQNPVSARRSD----SVILNVLYGPDAP- 240 S +R L++ N+ D A Y C + + + + VL P + Sbjct: 63 PDRFSGSSSGADRYLSISNIQPEDEAIYICGVGDTIKEQFVYVFGGGTKVTVLGQPKSTP 122 Query: 241 --TISPLNTSYRSGENLNLSCHAASNPPA--QYSWFVNGTFQQS---------------- 280 T+ P ++ L C ++ P+ +W NGT Sbjct: 123 TLTVFPPSSEELKENKATLVCLISNFSPSGVTVAWKANGTPITQGVDTSNPTKEGNKFMA 182 Query: 281 TQELFIPNITVNNSGSYTCQAHNSDTGLNRT 311 + L + + + S+TCQ + + ++ Sbjct: 183 SSFLHLTSDQWRSHNSFTCQVTHEGDTVEKS 213 Score = 36.5 bits (82), Expect = 0.040, Method: Composition-based stats. Identities = 19/142 (13%), Positives = 37/142 (26%), Gaps = 15/142 (10%) Query: 450 LIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGH-----SRTTVKTITVSAELPKPS 504 G+ + L ISNI ++ +Y C ++ T T+ + Sbjct: 65 RFSGSSSGADRYLSISNIQPEDEAIYICGVGDTIKEQFVYVFGGGTKVTVLGQPKSTPTL 124 Query: 505 ISSNNSKPVEDKDAVAFTCEPEAQNT---TYLWWVNGQSLPVSPRLQLSNGNRT------ 555 S ++ C + T W NG + Sbjct: 125 TVFPPSSEELKENKATLVCLISNFSPSGVTVAWKANGTPITQGVDTSNPTKEGNKFMASS 184 Query: 556 -LTLFNVTRNDARAYVCGIQNS 576 L L + ++ C + + Sbjct: 185 FLHLTSDQWRSHNSFTCQVTHE 206 Score = 29.9 bits (65), Expect = 4.4, Method: Composition-based stats. Identities = 24/164 (14%), Positives = 50/164 (30%), Gaps = 22/164 (13%) Query: 40 STPFNVAEGKEVLLLVHNLPQH-LFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGR 98 S F++ ++ + QH + WY+ + + R ++ +T G R Sbjct: 9 SASFSLGASAKLTCTLSR--QHSTYTIEWYQQQPLKPPRYVMELKKDGSHST-GDGIPDR 65 Query: 99 EIIYPNAS---LLIQNIIQNDTGFYTLHVIKSDLVNEEATGQF-----RVYPELPKP--- 147 + + L I NI D Y V + +E +V Sbjct: 66 FSGSSSGADRYLSISNIQPEDEAIYICGVGDT---IKEQFVYVFGGGTKVTVLGQPKSTP 122 Query: 148 --SISSNNSKPVEDKDAVAFTCEPETQDA--TYLWWVNNQSLPV 187 ++ +S+ +++ A + T W N + Sbjct: 123 TLTVFPPSSEELKENKATLVCLISNFSPSGVTVAWKANGTPITQ 166 >4JJH-A nrPDB Length = 133 Score = 44.2 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 26/123 (21%), Positives = 47/123 (38%), Gaps = 9/123 (7%) Query: 37 TIESTPFNVAEGKEVLLLVHNLPQHLFG-YSWYKGERVDGNRQIIGYVIGTQQATPGPAY 95 T + + + ++ G +W + + +G Q + + PAY Sbjct: 10 TSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEG-AQELALLHSKYGLHVSPAY 68 Query: 96 SGREIIYP------NASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSI 149 GR P + S+L++N +Q D G Y V + +A + RV P PS+ Sbjct: 69 EGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVP-PLPSL 127 Query: 150 SSN 152 + N Sbjct: 128 AEN 130 Score = 39.2 bits (89), Expect = 0.007, Method: Composition-based stats. Identities = 18/129 (13%), Positives = 39/129 (30%), Gaps = 14/129 (10%) Query: 483 ASGHSRTTVKTITVSAELPKPSISSNNS---------KPVEDKDAVAFTCEPEAQNTTYL 533 + V T+ + + P +S V+ + ++ ++ Sbjct: 5 GGELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHV 64 Query: 534 W--WVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLY 591 + P PR L + ++ L N + D Y C + + + + L VL Sbjct: 65 SPAYEGRVEQPPPPRNPL---DGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLV 121 Query: 592 GPDTPIISP 600 P + Sbjct: 122 PPLPSLAEN 130 >4D3C-L nrPDB Length = 215 Score = 43.8 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 27/164 (16%), Positives = 55/164 (33%), Gaps = 15/164 (9%) Query: 427 YRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGH 486 +PG L + ASN + G+ L IS + +++ Y CQ+ ++G Sbjct: 38 QKPGQPPKLLIYGASNLESGVPSRFRGSGSGTEFTLTISGMKAEDAATYYCQSGYYSAGA 97 Query: 487 S--RTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNT---TYLWWVNGQSL 541 + T I + P I + + ++ + C W V+ Sbjct: 98 TFGAGTNVEIKRTVAAPSVFIFPPSDEQLKSG-TASVVCLLNNFYPREAKVQWKVDNALQ 156 Query: 542 PVSPRLQLS---------NGNRTLTLFNVTRNDARAYVCGIQNS 576 + + ++ + + TLTL + Y C + + Sbjct: 157 SGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQ 200 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 27/197 (13%), Positives = 55/197 (27%), Gaps = 40/197 (20%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T +P + S G + ++C A+ + +W+ G Sbjct: 5 TQTPSSVSAAVGGTVTINCQASQSVSNLLAWYQQKPGQPPKLLIYGASNLESGVPSRFRG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLN--RTTVTTITVYAEPPKPFITSNNSN 333 + + L I + ++ +Y CQ+ G T I P FI + Sbjct: 65 SGSGTEFTLTISGMKAEDAATYYCQSGYYSAGATFGAGTNVEIKRTVAAPSVFIFPPSDE 124 Query: 334 PVEDEDAVALTCEPEI--QNTTYLWWV----------NNQSLPVSPRLQLSNDNRTLTLL 381 ++ ++ C + W + + + TLTL Sbjct: 125 QLKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLS 183 Query: 382 SVTRNDVGPYECGIQNK 398 Y C + ++ Sbjct: 184 KADYEKHKVYACEVTHQ 200 Score = 37.2 bits (84), Expect = 0.022, Method: Composition-based stats. Identities = 33/216 (15%), Positives = 61/216 (28%), Gaps = 27/216 (12%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS---------------LPVSPRL 369 + +S V + C+ + L W + V R Sbjct: 3 DLTQTPSSVSAAVGGTVTINCQASQSVSNLLAWYQQKPGQPPKLLIYGASNLESGVPSRF 62 Query: 370 QLSNDNR--TLTLLSVTRNDVGPYEC-----GIQNKLSVDHSDPVILNVLYGPDDPTISP 422 + S TLT+ + D Y C + + V P P Sbjct: 63 RGSGSGTEFTLTISGMKAEDAATYYCQSGYYSAGATFGAGTNVEIKRTVA-APSVFIFPP 121 Query: 423 SYTYYRPGVNLSLSCHAASNP-PAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANN 481 S + G + P A+ W +D +Q + ++ K+S Y+ + Sbjct: 122 SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTL 180 Query: 482 SASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKD 517 + S K + E+ +SS +K + Sbjct: 181 TLSKADYEKHK--VYACEVTHQGLSSPVTKSFNRGE 214 Score = 36.8 bits (83), Expect = 0.029, Method: Composition-based stats. Identities = 31/211 (14%), Positives = 61/211 (28%), Gaps = 29/211 (13%) Query: 153 NSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRLQLSN 195 +S V C+ + L W + +P R S Sbjct: 9 SSVSAAVGGTVTINCQASQSVSNLLAWYQQKPGQPPKLLIYGASNLESGVPSRFRGSGSG 68 Query: 196 GNRTLTLFNVTRNDTASYKC-----ETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYR 250 TLT+ + D A+Y C A + + V P P + + Sbjct: 69 TEFTLTISGMKAEDAATYYCQSGYYSAGATFGAGTNVEIKRTVA-APSVFIFPPSDEQLK 127 Query: 251 SGENLNLSCHAASNPP--AQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGL 308 SG ++ C + P A+ W V+ Q + + +S +Y+ + + + Sbjct: 128 SG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTLSKA 185 Query: 309 NRTTVTTITVYAEPPKPFITSNNSNPVEDED 339 + E ++S + + Sbjct: 186 DYEK--HKVYACEVTHQGLSSPVTKSFNRGE 214 Score = 33.4 bits (74), Expect = 0.37, Method: Composition-based stats. Identities = 28/188 (14%), Positives = 50/188 (26%), Gaps = 35/188 (18%) Query: 66 SWYKGERVDGNRQIIGYVIGTQQATPGP---AYSGREIIYPNASLLIQNIIQNDTGFYTL 122 +WY+ + + +I + P + SG E +L I + D Y Sbjct: 34 AWYQQKPGQPPKLLIYGASNLESGVPSRFRGSGSGTEF-----TLTISGMKAEDAATYYC 88 Query: 123 H-------VIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQD-- 173 N + + P I + + ++ A Sbjct: 89 QSGYYSAGATFGAGTN----VEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPRE 144 Query: 174 ATYLWWVNN---------QSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ-----N 219 A W V+N + + + TLTL Y CE + Sbjct: 145 AKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSS 204 Query: 220 PVSARRSD 227 PV+ + Sbjct: 205 PVTKSFNR 212 >5VF3-Z nrPDB Length = 376 Score = 43.8 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 40/251 (15%), Positives = 88/251 (35%), Gaps = 26/251 (10%) Query: 444 PAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKP 503 A +S+++ G Q T ++ +N T G T +A + + ++T T+ V+ P Sbjct: 50 EATFSYVLKGPAGQKTIKVVATN-TLSEGGPETAEATTTITVKNKTQTTTLAVTPASPAA 108 Query: 504 SISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTR 563 + + A +P+ + TY W+V+ + S T Sbjct: 109 GVIGTPVQF-----TAALASQPDGASATYQWYVDDSQVGGETNSTFSYTPTT-------- 155 Query: 564 NDARAYVCGIQNSVSANRSDPVT-----LDV--LYGPDTPIISPPDSSYLSGANLNLSCH 616 + + C Q + + + VT L V ++PP + A+ + + Sbjct: 156 SGVKRIKCVAQVTATDYDALSVTSNEVSLTVNKKTMNPQVTLTPPSINVQQDASATFTAN 215 Query: 617 SASNPSP---QYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSIT 673 P YSW+ + P + + + + ++ G+ V+ T + + V Sbjct: 216 VTGAPEEAQITYSWKKDSSPVEGST--NVYTVDTSSVGSQTIEVTATVTAADYNPVTVTK 273 Query: 674 VSASGTSPGLS 684 + ++ Sbjct: 274 TGNVTVTAKVA 284 >1UB5-L nrPDB Length = 214 Score = 43.8 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 41/201 (20%), Positives = 67/201 (33%), Gaps = 46/201 (22%) Query: 332 SNPVEDEDAVALTCEP-----EIQNTTYLWWVNNQSLPVSPRLQL--------------- 371 SNPV + +++C TYL+W + SP+L + Sbjct: 10 SNPVTLGTSASISCRSTKSLLHSNGITYLYWYLQKP-GQSPQLLIYQMSNLASGVPNRFS 68 Query: 372 ---SNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYTY 426 S + TL + V DVG Y C +L L + PT+S P + Sbjct: 69 SSGSGTDFTLRISRVEAEDVGVYYCAQNLELPPTFGGGTKLEIKRADAAPTVSIFPPSSE 128 Query: 427 YRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFISN 466 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 129 QLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 188 Query: 467 ITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 189 DEYERHNGYTCEATHKTSTSP 209 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 29/166 (17%), Positives = 51/166 (30%), Gaps = 27/166 (16%) Query: 170 ETQDATYLWWVNNQSLPVSPRLQLSNGNRT---LTLFNVTRNDTASYKCETQNPVSARRS 226 Q L + + P S+G+ T L + V D Y C + Sbjct: 45 PGQSPQLLIYQMSNLASGVPNRFSSSGSGTDFTLRISRVEAEDVGVYYCAQNLELPPTFG 104 Query: 227 DSVILNVLYGPDAPTIS---PLNTSYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS- 280 L + APT+S P + SG ++ C + P W ++G+ +Q+ Sbjct: 105 GGTKLEIKRADAAPTVSIFPPSSEQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNG 163 Query: 281 -----------------TQELFIPNITVNNSGSYTCQAHNSDTGLN 309 + L + YTC+A + + Sbjct: 164 VLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNGYTCEATHKTSTSP 209 Score = 35.3 bits (79), Expect = 0.087, Method: Composition-based stats. Identities = 26/154 (16%), Positives = 47/154 (30%), Gaps = 26/154 (16%) Query: 510 SKPVEDKDAVAFTCEP-------------------EAQNTTYLWWVNGQ---SLPVSPRL 547 S PV + + +C Q+ L + +P Sbjct: 10 SNPVTLGTSASISCRSTKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLASGVPNRFSS 69 Query: 548 QLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSY 605 S + TL + V D Y C + L++ P +S PP S Sbjct: 70 SGSGTDFTLRISRVEAEDVGVYYCAQNLELPPTFGGGTKLEIKRADAAPTVSIFPPSSEQ 129 Query: 606 LSGANLNLSCHSASNPSPQYS--WRINGIPQQHT 637 L+ ++ C + + W+I+G +Q+ Sbjct: 130 LTSGGASVVCFLNNFYPKDINVKWKIDGSERQNG 163 >4QNP-F nrPDB Length = 212 Score = 43.8 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 35/201 (17%), Positives = 60/201 (29%), Gaps = 38/201 (18%) Query: 325 PFITSNNSNPVEDEDAVALTC--------------EPEIQNTTYLWWVNNQSLPVSPRLQ 370 S + V +TC +P +++ +N + V R Sbjct: 3 VLSQSPAILSASPGEKVTMTCRTSSSVSYMHWYQQKPGSSPKPWIYATSNLASGVPFRFS 62 Query: 371 LSNDNRT--LTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYTY 426 S + LT+ V D Y C N L + PT+S P + Sbjct: 63 GSGSGTSYSLTISRVEAEDAATYYCQQWNSNPPTFGGGTKLEIKRADAAPTVSIFPPSSE 122 Query: 427 YRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFISN 466 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 123 QLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 182 Query: 467 ITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 183 DEYERHNSYTCEATHKTSTSP 203 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 29/197 (14%), Positives = 54/197 (27%), Gaps = 36/197 (18%) Query: 241 TISPLNTSYRSGENLNLSCHAASN--------------PPAQYS----------WFVNGT 276 + SP S GE + ++C +S+ P + +G+ Sbjct: 5 SQSPAILSASPGEKVTMTCRTSSSVSYMHWYQQKPGSSPKPWIYATSNLASGVPFRFSGS 64 Query: 277 FQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTIT--VYAEPPKPFITSNNSNP 334 ++ L I + ++ +Y CQ NS+ A P ++ Sbjct: 65 GSGTSYSLTISRVEAEDAATYYCQQWNSNPPTFGGGTKLEIKRADAAPTVSIFPPSSEQL 124 Query: 335 VEDEDAVALTCEPEIQNTTYLWWVNNQS----------LPVSPRLQLSNDNRTLTLLSVT 384 +V + W + S + + + TLTL Sbjct: 125 TSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDE 184 Query: 385 RNDVGPYECGIQNKLSV 401 Y C +K S Sbjct: 185 YERHNSYTCEATHKTST 201 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 34/190 (17%), Positives = 61/190 (32%), Gaps = 42/190 (22%) Query: 160 KDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRLQLSNGNRTLTL 202 + V TC + +Y+ W + +P S + +LT+ Sbjct: 16 GEKVTMTC-RTSSSVSYMHWYQQKPGSSPKPWIYATSNLASGVPFRFSGSGSGTSYSLTI 74 Query: 203 FNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTSYRSGENLNLSC 259 V D A+Y C+ N L + APT+S P + SG ++ C Sbjct: 75 SRVEAEDAATYYCQQWNSNPPTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSG-GASVVC 133 Query: 260 HAASNPPAQY--SWFVNGTFQQS------------------TQELFIPNITVNNSGSYTC 299 + P W ++G+ +Q+ + L + SYTC Sbjct: 134 FLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTC 193 Query: 300 QAHNSDTGLN 309 +A + + Sbjct: 194 EATHKTSTSP 203 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 32/197 (16%), Positives = 57/197 (28%), Gaps = 38/197 (19%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSP----------------RLQL 549 S + V TC + + W+ P Sbjct: 6 QSPAILSASPGEKVTMTCRTSSSVSYMHWYQQKPGSSPKPWIYATSNLASGVPFRFSGSG 65 Query: 550 SNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSYLS 607 S + +LT+ V DA Y C NS L++ P +S PP S L+ Sbjct: 66 SGTSYSLTISRVEAEDAATYYCQQWNSNPPTFGGGTKLEIKRADAAPTVSIFPPSSEQLT 125 Query: 608 GANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKITP 647 ++ C + + W+I+G +Q+ L + K Sbjct: 126 SGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEY 185 Query: 648 NNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 ERHNSYTCEATHKTSTS 202 Score = 36.8 bits (83), Expect = 0.035, Method: Composition-based stats. Identities = 30/165 (18%), Positives = 53/165 (32%), Gaps = 14/165 (8%) Query: 427 YRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGH 486 +PG + +A SN + + G+ + L IS + +++ Y CQ NS Sbjct: 37 QKPGSSPKPWIYATSNLASGVPFRFSGSGSGTSYSLTISRVEAEDAATYYCQQWNSNPPT 96 Query: 487 -SRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTT---YLWWVNGQSLP 542 T I + P SI +S+ + + C W ++G Sbjct: 97 FGGGTKLEIKRADAAPTVSIFPPSSEQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQ 155 Query: 543 V---------SPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVS 578 + + + TLTL +Y C + S Sbjct: 156 NGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTS 200 >1HNG-A nrPDB Length = 176 Score = 43.4 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 22/138 (15%), Positives = 45/138 (32%), Gaps = 7/138 (5%) Query: 179 WVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSAR-RSDSVILNVLYGP 237 + + N L + N+TR+D+ +Y + R + ++ L +L Sbjct: 42 FKRKMKPFLKSGAFEILANGDLKIKNLTRDDSGTYNVTVYSTNGTRILNKALDLRILEMV 101 Query: 238 DAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSY 297 P I Y N L+C + + +S ++ + N + Sbjct: 102 SKPMI------YWECSNATLTCEVLEGTDVELKLYQGKEHLRSLRQKTMSYQWTNLRAPF 155 Query: 298 TCQAHNSDTGLNRTTVTT 315 C+A N + + V Sbjct: 156 KCKAVNRVSQESEMEVVN 173 Score = 38.0 bits (86), Expect = 0.016, Method: Composition-based stats. Identities = 29/136 (21%), Positives = 47/136 (34%), Gaps = 16/136 (11%) Query: 96 SGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLV-NEEATGQFRVYPELPKPSISSNNS 154 SG I N L I+N+ ++D+G Y + V ++ R+ + KP I Sbjct: 52 SGAFEILANGDLKIKNLTRDDSGTYNVTVYSTNGTRILNKALDLRILEMVSKPMIYW--- 108 Query: 155 KPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYK 214 + TCE L + S R + + T N+ +K Sbjct: 109 ----ECSNATLTCEVLEGTDVELKLYQGKEHLRSLRQKTMSYQWT----NLRAP----FK 156 Query: 215 CETQNPVSARRSDSVI 230 C+ N VS V+ Sbjct: 157 CKAVNRVSQESEMEVV 172 Score = 36.1 bits (81), Expect = 0.054, Method: Composition-based stats. Identities = 21/129 (16%), Positives = 36/129 (27%), Gaps = 17/129 (13%) Query: 459 TQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDA 518 +L I N+T +SG Y ++ + + + KP + Sbjct: 60 NGDLKIKNLTRDDSGTYNVTVYSTNGTRILNKALDLRILEMVSKP-------MIYWECSN 112 Query: 519 VAFTCEP-EAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSV 577 TCE E + + + L + +S L + C N V Sbjct: 113 ATLTCEVLEGTDVELKLYQGKEHLRSLRQKTMSYQWTNLR---------APFKCKAVNRV 163 Query: 578 SANRSDPVT 586 S V Sbjct: 164 SQESEMEVV 172 Score = 33.8 bits (75), Expect = 0.30, Method: Composition-based stats. Identities = 22/120 (18%), Positives = 40/120 (33%), Gaps = 7/120 (5%) Query: 375 NRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVI-LNVLYGPDDPTISPSYTYYRPGVNL 433 N L + ++TR+D G Y + + + + L +L P I Y N Sbjct: 60 NGDLKIKNLTRDDSGTYNVTVYSTNGTRILNKALDLRILEMVSKPMI------YWECSNA 113 Query: 434 SLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKT 493 +L+C + + ++ +S + C+A N S S V Sbjct: 114 TLTCEVLEGTDVELKLYQGKEHLRSLRQKTMSYQWTNLRAPFKCKAVNRVSQESEMEVVN 173 Score = 32.6 bits (72), Expect = 0.57, Method: Composition-based stats. Identities = 9/47 (19%), Positives = 19/47 (40%) Query: 637 TQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGL 683 L I +T +++GTY V + R + + + + P + Sbjct: 60 NGDLKIKNLTRDDSGTYNVTVYSTNGTRILNKALDLRILEMVSKPMI 106 >1RUQ-L nrPDB Length = 217 Score = 43.4 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 29/166 (17%), Positives = 53/166 (31%), Gaps = 27/166 (16%) Query: 170 ETQDATYLWWVNNQSLPVSPRLQLSNGNRT---LTLFNVTRNDTASYKCETQNPVSARRS 226 Q L + ++ +P +G+ T L + V D Y C + Sbjct: 45 PGQSPQLLIYQMSKLASGAPDRFSGSGSGTDFTLRISRVEAEDVGVYYCAQNLELPYTFG 104 Query: 227 DSVILNVLYGPDAPTIS---PLNTSYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS- 280 L + APT+S P + SG ++ C + P W ++G+ +Q+ Sbjct: 105 GGTKLEIKRADAAPTVSIFPPSSEQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNG 163 Query: 281 -----------------TQELFIPNITVNNSGSYTCQAHNSDTGLN 309 + L + SYTC+A + + Sbjct: 164 VLNSWTDQDTKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSP 209 Score = 43.4 bits (100), Expect = 4e-04, Method: Composition-based stats. Identities = 38/201 (18%), Positives = 66/201 (32%), Gaps = 46/201 (22%) Query: 332 SNPVEDEDAVALTCEPE-----IQNTTYLWWVNNQSLPVSPRLQL--------------- 371 SNPV + +++C +++W + SP+L + Sbjct: 10 SNPVTLGASASISCRSSKSLLNSNGIIHMYWYLQKP-GQSPQLLIYQMSKLASGAPDRFS 68 Query: 372 ---SNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYTY 426 S + TL + V DVG Y C +L L + PT+S P + Sbjct: 69 GSGSGTDFTLRISRVEAEDVGVYYCAQNLELPYTFGGGTKLEIKRADAAPTVSIFPPSSE 128 Query: 427 YRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFISN 466 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 129 QLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDTKDSTYSMSSTLTLTK 188 Query: 467 ITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 189 DEYERHNSYTCEATHKTSTSP 209 Score = 36.1 bits (81), Expect = 0.053, Method: Composition-based stats. Identities = 29/206 (14%), Positives = 63/206 (30%), Gaps = 34/206 (16%) Query: 493 TITVSAELPKPSISSNNSKPVEDKDA---------VAFTCEPEAQNTTYLWWVNGQ---S 540 +T +A ++ ++ S + + + + Q+ L + + Sbjct: 3 VLTQAAFSNPVTLGASASISCRSSKSLLNSNGIIHMYWYLQKPGQSPQLLIYQMSKLASG 62 Query: 541 LPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS- 599 P S + TL + V D Y C + L++ P +S Sbjct: 63 APDRFSGSGSGTDFTLRISRVEAEDVGVYYCAQNLELPYTFGGGTKLEIKRADAAPTVSI 122 Query: 600 -PPDSSYLSGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------Q 638 PP S L+ ++ C + + W+I+G +Q+ Sbjct: 123 FPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDTKDSTYSMSS 182 Query: 639 VLFIAKITPNNNGTYACFVSNLATGR 664 L + K + +Y C ++ + Sbjct: 183 TLTLTKDEYERHNSYTCEATHKTSTS 208 >4XXD-A nrPDB Length = 219 Score = 43.0 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 34/214 (15%), Positives = 65/214 (30%), Gaps = 33/214 (15%) Query: 154 SKPVEDKDAVAFTCEPE-----TQDATYLWWVNNQSLPVSPRLQL--------------- 193 S PV + +C + YL W + SPRL + Sbjct: 10 SLPVTLGQPASISCRSSQSLIYSDGNAYLHWFLQKPG-QSPRLLIYKVSNRFSGVPDRFS 68 Query: 194 ---SNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNT 247 S + TL + V D Y C V + + AP++ P + Sbjct: 69 GSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPWTFGQGTKVEIKRTVAAPSVFIFPPSDE 128 Query: 248 SYRSGENLNLSCHAASNPP--AQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSD 305 +SG ++ C + P A+ W V+ Q + + +S +Y+ + + Sbjct: 129 QLKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTL 186 Query: 306 TGLNRTTVTTITVYAEPPKPFITSNNSNPVEDED 339 + + E ++S + + Sbjct: 187 SKADYEK--HKVYACEVTHQGLSSPVTKSFNRGE 218 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 39/220 (17%), Positives = 67/220 (30%), Gaps = 31/220 (14%) Query: 325 PFITSNNSNPVEDEDAVALTCEPE-----IQNTTYLWWVNNQSLPVSPRLQL-------- 371 S S PV +++C YL W + SPRL + Sbjct: 3 VMTQSPLSLPVTLGQPASISCRSSQSLIYSDGNAYLHWFLQKP-GQSPRLLIYKVSNRFS 61 Query: 372 ----------SNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNV---LYGPDDP 418 S + TL + V DVG Y C + + + + P Sbjct: 62 GVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPWTFGQGTKVEIKRTVAAPSVF 121 Query: 419 TISPSYTYYRPGVNLSLSCHAASNP-PAQYSWLIDGNIQQHTQELFISNITEKNSGLYTC 477 PS + G + P A+ W +D +Q + ++ K+S Y+ Sbjct: 122 IFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSL 180 Query: 478 QANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKD 517 + + S K + E+ +SS +K + Sbjct: 181 SSTLTLSKADYEKHK--VYACEVTHQGLSSPVTKSFNRGE 218 Score = 34.9 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 32/209 (15%), Positives = 60/209 (28%), Gaps = 29/209 (13%) Query: 506 SSNNSKPVEDKDAVAFTCEP-------------------EAQNTTYLWWVNGQ---SLPV 543 S S PV + +C Q+ L + +P Sbjct: 6 QSPLSLPVTLGQPASISCRSSQSLIYSDGNAYLHWFLQKPGQSPRLLIYKVSNRFSGVPD 65 Query: 544 SPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSV--SANRSDPVTLDVLYGPDTPIISPP 601 S + TL + V D Y C V + + V + + I PP Sbjct: 66 RFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPWTFGQGTKVEIKRTVAAPSVFIFPP 125 Query: 602 DSSYLSGANLNLSCHSASNPS--PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSN 659 L ++ C + + W+++ Q + + ++ TY+ + Sbjct: 126 SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTL 184 Query: 660 LATGRNNSIVKSITVSASGTSPGLSAGAT 688 + + K + T GLS+ T Sbjct: 185 TLSKADYEKHKVY--ACEVTHQGLSSPVT 211 Score = 34.9 bits (78), Expect = 0.13, Method: Composition-based stats. Identities = 32/213 (15%), Positives = 56/213 (26%), Gaps = 31/213 (14%) Query: 40 STPFNVAEGKEVLLLVHNLPQHLFGYS-------WYKGERVDGNRQIIGYVIGTQQATPG 92 S P + + + YS W+ + R +I V P Sbjct: 10 SLPVTLGQPASISCR----SSQSLIYSDGNAYLHWFLQKPGQSPRLLIYKVSNRFSGVPD 65 Query: 93 PAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVN--EEATGQFRVYPELPKPSIS 150 +SG + +L I + D G Y + + + P I Sbjct: 66 -RFSGSGSGT-DFTLKISRVEAEDVGVYYCSQSTHVPWTFGQGTKVEIKRTVAAPSVFIF 123 Query: 151 SNNSKPVEDKDAVAFTCEPETQD--ATYLWWVNN---------QSLPVSPRLQLSNGNRT 199 + + ++ A A W V+N + + + T Sbjct: 124 PPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSST 183 Query: 200 LTLFNVTRNDTASYKCETQ-----NPVSARRSD 227 LTL Y CE +PV+ + Sbjct: 184 LTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR 216 >1UCB-L nrPDB Length = 219 Score = 43.0 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 33/214 (15%), Positives = 63/214 (29%), Gaps = 31/214 (14%) Query: 153 NSKPVEDKDAVAFTCE-----PETQDATYLWWVNNQS-------LPVSPRLQL------- 193 S PV D + +C TYL W + + Sbjct: 9 VSLPVSLGDQASISCRSSQIIVHNNGNTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFS 68 Query: 194 ---SNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNT 247 S + TL + V D Y C + V L + AP++ P + Sbjct: 69 GSGSGTDFTLKISRVEAEDLGVYYCFQGSHVPFTFGSGTKLEIKRTVAAPSVFIFPPSDE 128 Query: 248 SYRSGENLNLSCHAASNPP--AQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSD 305 +SG ++ C + P A+ W V+ Q + + +S +Y+ + + Sbjct: 129 QLKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTL 186 Query: 306 TGLNRTTVTTITVYAEPPKPFITSNNSNPVEDED 339 + + E ++S + + Sbjct: 187 SKADYEK--HKVYACEVTHQGLSSPVTKSFNRGE 218 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 39/214 (18%), Positives = 67/214 (31%), Gaps = 29/214 (13%) Query: 330 NNSNPVEDEDAVALTCEP-----EIQNTTYLWWV---------------NNQSLPVSPRL 369 S PV D +++C TYL W +N+ V R Sbjct: 8 PVSLPVSLGDQASISCRSSQIIVHNNGNTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRF 67 Query: 370 QLSNDNR--TLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNV---LYGPDDPTISPSY 424 S TL + V D+G Y C + + L + + P PS Sbjct: 68 SGSGSGTDFTLKISRVEAEDLGVYYCFQGSHVPFTFGSGTKLEIKRTVAAPSVFIFPPSD 127 Query: 425 TYYRPGVNLSLSCHAASNP-PAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSA 483 + G + P A+ W +D +Q + ++ K+S Y+ + + Sbjct: 128 EQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTL 186 Query: 484 SGHSRTTVKTITVSAELPKPSISSNNSKPVEDKD 517 S K + E+ +SS +K + Sbjct: 187 SKADYEKHK--VYACEVTHQGLSSPVTKSFNRGE 218 Score = 36.8 bits (83), Expect = 0.033, Method: Composition-based stats. Identities = 32/209 (15%), Positives = 60/209 (28%), Gaps = 29/209 (13%) Query: 506 SSNNSKPVEDKDAVAFTCEP-------------------EAQNTTYLWWVNGQ---SLPV 543 S PV D + +C Q+ L + +P Sbjct: 6 QIPVSLPVSLGDQASISCRSSQIIVHNNGNTYLEWYLQKPGQSPQLLIYKVSNRFSGVPD 65 Query: 544 SPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVL--YGPDTPIISPP 601 S + TL + V D Y C + V L++ + I PP Sbjct: 66 RFSGSGSGTDFTLKISRVEAEDLGVYYCFQGSHVPFTFGSGTKLEIKRTVAAPSVFIFPP 125 Query: 602 DSSYLSGANLNLSCHSASNPS--PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSN 659 L ++ C + + W+++ Q + + ++ TY+ + Sbjct: 126 SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTL 184 Query: 660 LATGRNNSIVKSITVSASGTSPGLSAGAT 688 + + K + T GLS+ T Sbjct: 185 TLSKADYEKHKVY--ACEVTHQGLSSPVT 211 >1GPO-L nrPDB Length = 219 Score = 43.0 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 40/208 (19%), Positives = 68/208 (32%), Gaps = 46/208 (22%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNT-----TYLWWVNNQSLPVSPRLQL-------- 371 S + V ++V+++C TYL+W +S SPRL + Sbjct: 3 ELTQSPATLSVTPGNSVSISCRASQSLVNEDGNTYLFWYQQKSH-ESPRLLIKYASQSIS 61 Query: 372 ----------SNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS 421 S + TL++ SV D+ Y C L + PT+S Sbjct: 62 GIPSRFSGSGSGTDFTLSINSVETEDLAVYFCQQITDWPFTFGGGTKLEIKRADAAPTVS 121 Query: 422 --PSYTYYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------T 459 P + S+ C + P + W IDG+ +Q+ + Sbjct: 122 IFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMS 181 Query: 460 QELFISNITEKNSGLYTCQANNSASGHS 487 L ++ + YTC+A + S Sbjct: 182 STLTLTKDEYERHNSYTCEATHKTSTSP 209 Score = 35.7 bits (80), Expect = 0.068, Method: Composition-based stats. Identities = 39/209 (18%), Positives = 73/209 (34%), Gaps = 29/209 (13%) Query: 128 DLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDAT-YLWWVNNQSLP 186 +L AT + S ++ S ED + F + ++ ++ L +QS+ Sbjct: 3 ELTQSPATLSVTPGNSVS-ISCRASQSLVNEDGNTYLFWYQQKSHESPRLLIKYASQSIS 61 Query: 187 VSPRLQLSNGNRT---LTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS 243 P +G+ T L++ +V D A Y C+ L + APT+S Sbjct: 62 GIPSRFSGSGSGTDFTLSINSVETEDLAVYFCQQITDWPFTFGGGTKLEIKRADAAPTVS 121 Query: 244 ---PLNTSYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------ 280 P + SG ++ C + P W ++G+ +Q+ Sbjct: 122 IFPPSSEQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSM 180 Query: 281 TQELFIPNITVNNSGSYTCQAHNSDTGLN 309 + L + SYTC+A + + Sbjct: 181 SSTLTLTKDEYERHNSYTCEATHKTSTSP 209 >5A2I-H nrPDB Length = 244 Score = 43.0 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 35/214 (16%), Positives = 55/214 (25%), Gaps = 68/214 (31%) Query: 249 YRSGENLNLSCHAAS-------------NPPAQYSW-----------------FVNGTFQ 278 + G ++ LSC A+ +P W V G F Sbjct: 12 VQPGGSMKLSCVASGFTFSNYWMNWVRQSPEKGLEWVAEIRLKSNNYATHYAESVKGRFT 71 Query: 279 QSTQE------LFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPK-------- 324 S + L + N+ ++G Y C + T T++ + Sbjct: 72 ISRDDSKSSVYLQMNNLRAEDTGIYYCTGVGQFAYWGQGTTVTVSASSGGGGSGGGGGSS 131 Query: 325 ----PFITSNNSNPVEDEDAVALTCEPEIQNTT---YLWWVNNQSL-------------- 363 +T ++ + V LTC T Y WV + Sbjct: 132 GSSDIVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRA 191 Query: 364 ---PVSPRLQLSNDNRTLTLLSVTRNDVGPYECG 394 P L D LT+ D Y C Sbjct: 192 PGVPARFSGSLIGDKAALTITGAQTEDEAIYFCA 225 Score = 41.8 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 33/213 (15%), Positives = 54/213 (25%), Gaps = 40/213 (18%) Query: 43 FNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYS--GREI 100 ++ + + +W + G + + + A S GR Sbjct: 12 VQPGGSMKLSCVASGFTFSNYWMNWVRQSPEKGLEWVAEIRLKSNNYATHYAESVKGRFT 71 Query: 101 IYPNAS-----LLIQNIIQNDTGFYTL-------------HVIKSDLVNEEATGQFRVYP 142 I + S L + N+ DTG Y V S +G Sbjct: 72 ISRDDSKSSVYLQMNNLRAEDTGIYYCTGVGQFAYWGQGTTVTVSASSGGGGSGGGGGSS 131 Query: 143 ELPKPSISSNNSKPVEDKDAVAFTCEPETQDAT---YLWWVNNQS--------------- 184 ++ ++ + V TC T T Y WV + Sbjct: 132 GSSDIVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRA 191 Query: 185 --LPVSPRLQLSNGNRTLTLFNVTRNDTASYKC 215 +P L LT+ D A Y C Sbjct: 192 PGVPARFSGSLIGDKAALTITGAQTEDEAIYFC 224 Score = 41.1 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 20/150 (13%), Positives = 33/150 (22%), Gaps = 42/150 (28%) Query: 199 TLTLFNVTRNDTASYKC--------------ETQNPVSARRSDSVILNVLYGPDAPTISP 244 L + N+ DT Y C T + S D Sbjct: 82 YLQMNNLRAEDTGIYYCTGVGQFAYWGQGTTVTVSASSGGGGSGGGGGSSGSSDIVVTQE 141 Query: 245 LNTSYRSGENLNLSCHAA----------------------------SNPPAQYSWFVNGT 276 + GE + L+C ++ +N +G+ Sbjct: 142 SALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRAPGVPARFSGS 201 Query: 277 FQQSTQELFIPNITVNNSGSYTCQAHNSDT 306 L I + Y C S+ Sbjct: 202 LIGDKAALTITGAQTEDEAIYFCALWYSNH 231 Score = 37.2 bits (84), Expect = 0.022, Method: Composition-based stats. Identities = 36/242 (14%), Positives = 60/242 (24%), Gaps = 68/242 (28%) Query: 417 DPTISPSYTYYRPGVNLSLSCHAAS-------------NPPAQYSWLIDGNIQQHTQ--- 460 +PG ++ LSC A+ +P W+ + ++ + Sbjct: 2 VQLQESGGGLVQPGGSMKLSCVASGFTFSNYWMNWVRQSPEKGLEWVAEIRLKSNNYATH 61 Query: 461 -------ELFIS-------------NITEKNSGLYTCQA----NNSASGHSRTTVKTITV 496 IS N+ +++G+Y C G + T + Sbjct: 62 YAESVKGRFTISRDDSKSSVYLQMNNLRAEDTGIYYCTGVGQFAYWGQGTTVTVSASSGG 121 Query: 497 SAELPKPSISSNNSKPVED--------KDAVAFTCEPEAQNTT---YLWWVNGQS----- 540 S ++ V + V TC T Y WV + Sbjct: 122 GGSGGGGGSSGSSDIVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFT 181 Query: 541 ------------LPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLD 588 +P L LT+ D Y C + S L Sbjct: 182 GLIGGTNNRAPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWYSNHWVFGGGTKLT 241 Query: 589 VL 590 VL Sbjct: 242 VL 243 >1BBD-L nrPDB Length = 220 Score = 43.0 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 39/211 (18%), Positives = 64/211 (30%), Gaps = 51/211 (24%) Query: 325 PFITSNNSNPVEDEDAVALTCE---------------------PEIQNTTYLWWVNNQSL 363 S +S V + V +TC+ P ++W + + Sbjct: 3 VMTQSPSSLTVTTGEKVTMTCKSSQSLLNSRTQKNYLTWYQQKPGQSPKLLIYWASTRES 62 Query: 364 PVSPRLQLSNDNR--TLTLLSVTRNDVGPYECGIQNK----LSVDHSDPVILN-VLYGPD 416 V R S TL++ V D+ Y C QN L+ + L P Sbjct: 63 GVPDRFTGSGSGTDFTLSISGVQAEDLAVYYC--QNNYNYPLTFGAGTKLELKRADAAPT 120 Query: 417 DPTISPSYTYYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH---------------- 458 PS G S+ C + P + W IDG+ +Q+ Sbjct: 121 VSIFPPSSEQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTY 179 Query: 459 --TQELFISNITEKNSGLYTCQANNSASGHS 487 + L ++ + YTC+A + S Sbjct: 180 SMSSTLTLTKDEYERHNSYTCEATHKTSTSP 210 Score = 38.8 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 37/207 (17%), Positives = 63/207 (30%), Gaps = 47/207 (22%) Query: 149 ISSNNSKPVEDKDAVAFTCE---------------------PETQDATYLWWVNNQSLPV 187 S +S V + V TC+ P ++W + + V Sbjct: 5 TQSPSSLTVTTGEKVTMTCKSSQSLLNSRTQKNYLTWYQQKPGQSPKLLIYWASTRESGV 64 Query: 188 SPRLQLSNGNR--TLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS-- 243 R S TL++ V D A Y C+ L + APT+S Sbjct: 65 PDRFTGSGSGTDFTLSISGVQAEDLAVYYCQNNYNYPLTFGAGTKLELKRADAAPTVSIF 124 Query: 244 -PLNTSYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQ 282 P + SG ++ C + P W ++G+ +Q+ + Sbjct: 125 PPSSEQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSS 183 Query: 283 ELFIPNITVNNSGSYTCQAHNSDTGLN 309 L + SYTC+A + + Sbjct: 184 TLTLTKDEYERHNSYTCEATHKTSTSP 210 >3U0W-L nrPDB Length = 214 Score = 42.6 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 35/213 (16%), Positives = 66/213 (30%), Gaps = 24/213 (11%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRL---------------- 369 + +S D V ++C + YL W + L Sbjct: 4 MTQTTSSLSASLGDRVTISCSASQGISNYLNWFQQKPDGTVKLLIYYTSSLHSGVPSRFS 63 Query: 370 -QLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNV---LYGPDDPTISPSYT 425 S + +LT+ ++ D+ Y C KL L + + P PS Sbjct: 64 GSGSGTDYSLTISNLEPEDIATYYCQQYRKLPYTFGGGTKLEIKRTVAAPSVFIFPPSDE 123 Query: 426 YYRPGVNLSLSCHAASNP-PAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSAS 484 + G + P A+ W +D +Q + ++ K+S Y+ + + S Sbjct: 124 QLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTLS 182 Query: 485 GHSRTTVKTITVSAELPKPSISSNNSKPVEDKD 517 K + E+ +SS +K + Sbjct: 183 KADYEKHK--VYACEVTHQGLSSPVTKSFNRGE 213 Score = 41.8 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 32/213 (15%), Positives = 68/213 (31%), Gaps = 26/213 (12%) Query: 149 ISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRL 191 + +S D V +C + YL W + +P Sbjct: 5 TQTTSSLSASLGDRVTISCSASQGISNYLNWFQQKPDGTVKLLIYYTSSLHSGVPSRFSG 64 Query: 192 QLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTS 248 S + +LT+ N+ D A+Y C+ + L + AP++ P + Sbjct: 65 SGSGTDYSLTISNLEPEDIATYYCQQYRKLPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQ 124 Query: 249 YRSGENLNLSCHAASNPP--AQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDT 306 +SG ++ C + P A+ W V+ Q + + +S +Y+ + + + Sbjct: 125 LKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTLS 182 Query: 307 GLNRTTVTTITVYAEPPKPFITSNNSNPVEDED 339 + E ++S + + Sbjct: 183 KADYEK--HKVYACEVTHQGLSSPVTKSFNRGE 213 Score = 38.4 bits (87), Expect = 0.011, Method: Composition-based stats. Identities = 32/214 (14%), Positives = 64/214 (29%), Gaps = 32/214 (14%) Query: 37 TIESTPFNVAEGKEVLLLVHNLPQHLFGY-SWYKGERVDGNRQIIGYVIGTQQATPGPAY 95 T S ++ + + + Q + Y +W++ ++ DG +++ Y + + + Sbjct: 7 TTSSLSASLGDRVTISC---SASQGISNYLNWFQ-QKPDGTVKLLIYYTSSLHSGVPSRF 62 Query: 96 SGREIIYPNASLLIQNIIQNDTGFYTLHV------IKSDLVNEEATGQFRVYPELPKPSI 149 SG + SL I N+ D Y + + P I Sbjct: 63 SGSGSGT-DYSLTISNLEPEDIATYYCQQYRKLPYTFGGGT----KLEIKRTVAAPSVFI 117 Query: 150 SSNNSKPVEDKDAVAFTCEPETQD--ATYLWWVNN---------QSLPVSPRLQLSNGNR 198 + + ++ A A W V+N + + + Sbjct: 118 FPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS 177 Query: 199 TLTLFNVTRNDTASYKCETQ-----NPVSARRSD 227 TLTL Y CE +PV+ + Sbjct: 178 TLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR 211 Score = 37.6 bits (85), Expect = 0.017, Method: Composition-based stats. Identities = 28/196 (14%), Positives = 53/196 (27%), Gaps = 39/196 (19%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T + + S G+ + +SC A+ +WF G Sbjct: 5 TQTTSSLSASLGDRVTISCSASQGISNYLNWFQQKPDGTVKLLIYYTSSLHSGVPSRFSG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQAHNS-DTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 + + L I N+ + +Y CQ + T I P FI + Sbjct: 65 SGSGTDYSLTISNLEPEDIATYYCQQYRKLPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQ 124 Query: 335 VEDEDAVALTCEPEI--QNTTYLWWV----------NNQSLPVSPRLQLSNDNRTLTLLS 382 ++ ++ C + W + + + TLTL Sbjct: 125 LKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSK 183 Query: 383 VTRNDVGPYECGIQNK 398 Y C + ++ Sbjct: 184 ADYEKHKVYACEVTHQ 199 Score = 37.2 bits (84), Expect = 0.023, Method: Composition-based stats. Identities = 30/204 (14%), Positives = 61/204 (29%), Gaps = 24/204 (11%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTY-LWWVNG----------------QSLPVSPRLQ 548 + +S D V +C + Y W+ +P Sbjct: 6 QTTSSLSASLGDRVTISCSASQGISNYLNWFQQKPDGTVKLLIYYTSSLHSGVPSRFSGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVL--YGPDTPIISPPDSSYL 606 S + +LT+ N+ D Y C + L++ + I PP L Sbjct: 66 GSGTDYSLTISNLEPEDIATYYCQQYRKLPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQL 125 Query: 607 SGANLNLSCHSASNPS--PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGR 664 ++ C + + W+++ Q + + ++ TY+ + + Sbjct: 126 KSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTLSKA 184 Query: 665 NNSIVKSITVSASGTSPGLSAGAT 688 + K + T GLS+ T Sbjct: 185 DYEKHKVY--ACEVTHQGLSSPVT 206 >1WWC-A nrPDB Length = 118 Score = 42.6 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 21/99 (21%), Positives = 31/99 (31%), Gaps = 19/99 (19%) Query: 585 VTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAK 644 V L V Y P + P+ + NP P W NG P + ++++ + Sbjct: 1 VALTVYYPPRVVSLEEPELRLEH----CIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEY 56 Query: 645 I---------------TPNNNGTYACFVSNLATGRNNSI 668 T NNG Y N N +I Sbjct: 57 YQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTI 95 Score = 38.0 bits (86), Expect = 0.015, Method: Composition-based stats. Identities = 15/77 (19%), Positives = 23/77 (29%), Gaps = 15/77 (19%) Query: 439 AASNPPAQYSWLIDGNIQQHTQE---------------LFISNITEKNSGLYTCQANNSA 483 NPP WL +G + ++ L + T N+G YT A N Sbjct: 29 VRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPL 88 Query: 484 SGHSRTTVKTITVSAEL 500 ++T Sbjct: 89 GTANQTINGHFLKEPFP 105 Score = 34.9 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 19/90 (21%), Positives = 26/90 (28%), Gaps = 17/90 (18%) Query: 257 LSCHAASNPPAQYSWFVNGTFQQSTQ---------------ELFIPNITVNNSGSYTCQA 301 + NPP W NG + ++ L T N+G+YT A Sbjct: 25 IEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIA 84 Query: 302 HNSDTGLNRTTVTTITVYAEPPKPFITSNN 331 N N+T EP S Sbjct: 85 KNPLGTANQTINGH--FLKEPFPVDEVSPT 112 Score = 31.1 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 8/62 (12%), Positives = 16/62 (25%), Gaps = 7/62 (11%) Query: 169 PETQDATYLWWVNNQSLPVSPRLQLSN-------GNRTLTLFNVTRNDTASYKCETQNPV 221 L W++N ++ L T + +Y +NP+ Sbjct: 29 VRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPL 88 Query: 222 SA 223 Sbjct: 89 GT 90 >1OTS-D nrPDB Length = 211 Score = 42.2 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 36/202 (17%), Positives = 63/202 (31%), Gaps = 40/202 (19%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS-----------------LPVSP 367 S D V +TC + +Y+ W +S +PV Sbjct: 3 VLTQSPAIMSAAPGDKVTMTCSASS-SVSYIHWYQQKSGTSPKRWIYDTSKLTSGVPVRF 61 Query: 368 RLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYT 425 S + +LT+ ++ D Y C + L +L PT+S P + Sbjct: 62 SGSGSGTSYSLTINTMEAEDAATYYCQQWSSHPQTFGGGTKLEILRADAAPTVSIFPPSS 121 Query: 426 YYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFIS 465 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 122 EQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLT 181 Query: 466 NITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 182 KDEYERHNSYTCEATHKTSTSP 203 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 30/198 (15%), Positives = 57/198 (28%), Gaps = 38/198 (19%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGT------FQQSTQELF--------- 285 T SP S G+ + ++C A+S+ + W+ + + T +L Sbjct: 5 TQSPAIMSAAPGDKVTMTCSASSS-VSYIHWYQQKSGTSPKRWIYDTSKLTSGVPVRFSG 63 Query: 286 ----------IPNITVNNSGSYTCQAHNSDTGL--NRTTVTTITVYAEPPKPFITSNNSN 333 I + ++ +Y CQ +S T + + A P ++ Sbjct: 64 SGSGTSYSLTINTMEAEDAATYYCQQWSSHPQTFGGGTKLEILRADAAPTVSIFPPSSEQ 123 Query: 334 PVEDEDAVALTCEPEIQNTTYLWWVNNQS----------LPVSPRLQLSNDNRTLTLLSV 383 +V + W + S + + + TLTL Sbjct: 124 LTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKD 183 Query: 384 TRNDVGPYECGIQNKLSV 401 Y C +K S Sbjct: 184 EYERHNSYTCEATHKTST 201 Score = 39.2 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 36/190 (18%), Positives = 64/190 (33%), Gaps = 42/190 (22%) Query: 160 KDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRLQLSNGNRTLTL 202 D V TC + +Y+ W +S +PV S + +LT+ Sbjct: 16 GDKVTMTCSASSS-VSYIHWYQQKSGTSPKRWIYDTSKLTSGVPVRFSGSGSGTSYSLTI 74 Query: 203 FNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTSYRSGENLNLSC 259 + D A+Y C+ + L +L APT+S P + SG ++ C Sbjct: 75 NTMEAEDAATYYCQQWSSHPQTFGGGTKLEILRADAAPTVSIFPPSSEQLTSG-GASVVC 133 Query: 260 HAASNPPAQY--SWFVNGTFQQS------------------TQELFIPNITVNNSGSYTC 299 + P W ++G+ +Q+ + L + SYTC Sbjct: 134 FLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTC 193 Query: 300 QAHNSDTGLN 309 +A + + Sbjct: 194 EATHKTSTSP 203 Score = 39.2 bits (89), Expect = 0.007, Method: Composition-based stats. Identities = 33/197 (16%), Positives = 60/197 (30%), Gaps = 38/197 (19%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQS----------------LPVSPRLQL 549 S D V TC + + W+ +PV Sbjct: 6 QSPAIMSAAPGDKVTMTCSASSSVSYIHWYQQKSGTSPKRWIYDTSKLTSGVPVRFSGSG 65 Query: 550 SNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSYLS 607 S + +LT+ + DA Y C +S L++L P +S PP S L+ Sbjct: 66 SGTSYSLTINTMEAEDAATYYCQQWSSHPQTFGGGTKLEILRADAAPTVSIFPPSSEQLT 125 Query: 608 GANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKITP 647 ++ C + + W+I+G +Q+ L + K Sbjct: 126 SGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEY 185 Query: 648 NNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 ERHNSYTCEATHKTSTS 202 >2XOT-A nrPDB Length = 361 Score = 42.2 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 15/60 (25%), Positives = 20/60 (33%), Gaps = 2/60 (3%) Query: 160 KDAVAFTCEPETQDATYLWWV--NNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCET 217 D + C+ + Q T +W N Q L +S N L V D Y C Sbjct: 261 GDTLTIRCDTKQQGMTKVWVSPSNEQVLSQGSNGSVSVRNGDLFFKKVQVEDGGVYTCYA 320 Score = 42.2 bits (97), Expect = 8e-04, Method: Composition-based stats. Identities = 19/77 (24%), Positives = 26/77 (33%), Gaps = 3/77 (3%) Query: 516 KDAVAFTCEPEAQNTTYLWWV--NGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGI 573 D + C+ + Q T +W N Q L +S N L V D Y C Sbjct: 261 GDTLTIRCDTKQQGMTKVWVSPSNEQVLSQGSNGSVSVRNGDLFFKKVQVEDGGVYTCYA 320 Query: 574 QNSVSANRSDPVTLDVL 590 + N + V L V Sbjct: 321 MGE-TFNETLSVELKVY 336 Score = 38.4 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 25/151 (16%), Positives = 46/151 (30%), Gaps = 18/151 (11%) Query: 355 LWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYG 414 L+ NN QL + + L SV Y C S + L+ Sbjct: 194 LYLHNNPLECDCKLYQLFSHWQYRQLSSVMDFQEDLY-CMH----SKKLHNIFSLDFF-- 246 Query: 415 PDDPTISPSYTYYRPGVNLSLSCH----------AASNPPAQYSWLIDGNIQQHTQELFI 464 + S G L++ C + + S +G++ +LF Sbjct: 247 -NCSEYKESAWEAHLGDTLTIRCDTKQQGMTKVWVSPSNEQVLSQGSNGSVSVRNGDLFF 305 Query: 465 SNITEKNSGLYTCQANNSASGHSRTTVKTIT 495 + ++ G+YTC A + + + Sbjct: 306 KKVQVEDGGVYTCYAMGETFNETLSVELKVY 336 Score = 35.7 bits (80), Expect = 0.071, Method: Composition-based stats. Identities = 19/76 (25%), Positives = 29/76 (38%), Gaps = 3/76 (3%) Query: 338 EDAVALTCEPEIQNTTYLWWV--NNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGI 395 D + + C+ + Q T +W N Q L +S N L V D G Y C Sbjct: 261 GDTLTIRCDTKQQGMTKVWVSPSNEQVLSQGSNGSVSVRNGDLFFKKVQVEDGGVYTCYA 320 Query: 396 QNKLSVDHSDPVILNV 411 + + + + V L V Sbjct: 321 MGE-TFNETLSVELKV 335 Score = 35.3 bits (79), Expect = 0.092, Method: Composition-based stats. Identities = 18/79 (22%), Positives = 26/79 (32%), Gaps = 14/79 (17%) Query: 252 GENLNLSCHAASNPPAQYSWFV-----------NGTFQQSTQELFIPNITVNNSGSYTCQ 300 G+ L + C + W NG+ +LF + V + G YTC Sbjct: 261 GDTLTIRCDTKQQGMTKV-WVSPSNEQVLSQGSNGSVSVRNGDLFFKKVQVEDGGVYTCY 319 Query: 301 AHNSDTGLNRTTVTTITVY 319 A N T + VY Sbjct: 320 A--MGETFNETLSVELKVY 336 >1PSK-L nrPDB Length = 213 Score = 42.2 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 31/201 (15%), Positives = 58/201 (28%), Gaps = 38/201 (18%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQ--------------NTTYLWWVNNQSLPVSPRLQ 370 S + V +TC +++ + + V R Sbjct: 3 VLTQSPAIMSASPGEKVTITCSASSSVSNIHWFQQKPGTFPKLWIYSTSTLASGVPGRFS 62 Query: 371 LSNDNRT--LTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYTY 426 S + LT+ + D Y C ++ L + PT+S P + Sbjct: 63 GSGSGTSYSLTISRMGAEDAATYYCQQRSGYPFTFGSGTKLEIKRADAAPTVSIFPPSSE 122 Query: 427 YRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFISN 466 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 123 QLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 182 Query: 467 ITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 183 DEYERHNSYTCEATHKTSTSP 203 Score = 41.1 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 31/194 (15%), Positives = 61/194 (31%), Gaps = 40/194 (20%) Query: 155 KPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVS----PRLQLSNG------------NR 198 + V TC + + W+ L++G + Sbjct: 11 MSASPGEKVTITCSASSSVSNIHWFQQKPGTFPKLWIYSTSTLASGVPGRFSGSGSGTSY 70 Query: 199 TLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTSYRSGENL 255 +LT+ + D A+Y C+ ++ L + APT+S P + SG Sbjct: 71 SLTISRMGAEDAATYYCQQRSGYPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSG-GA 129 Query: 256 NLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFIPNITVNNSG 295 ++ C + P W ++G+ +Q+ + L + Sbjct: 130 SVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHN 189 Query: 296 SYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 190 SYTCEATHKTSTSP 203 Score = 37.2 bits (84), Expect = 0.025, Method: Composition-based stats. Identities = 29/197 (14%), Positives = 58/197 (29%), Gaps = 38/197 (19%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNG----------------QSLPVSPRLQL 549 S + V TC + + W+ +P Sbjct: 6 QSPAIMSASPGEKVTITCSASSSVSNIHWFQQKPGTFPKLWIYSTSTLASGVPGRFSGSG 65 Query: 550 SNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSYLS 607 S + +LT+ + DA Y C ++ L++ P +S PP S L+ Sbjct: 66 SGTSYSLTISRMGAEDAATYYCQQRSGYPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLT 125 Query: 608 GANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKITP 647 ++ C + + W+I+G +Q+ L + K Sbjct: 126 SGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEY 185 Query: 648 NNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 ERHNSYTCEATHKTSTS 202 >2FD6-L nrPDB Length = 214 Score = 42.2 bits (97), Expect = 8e-04, Method: Composition-based stats. Identities = 35/203 (17%), Positives = 58/203 (28%), Gaps = 49/203 (24%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGT------------------------ 276 T SP T+ G+ + ++C A+S+ + W+ + Sbjct: 5 TQSPDITAASLGQKVTITCSASSS-VSYMHWYQQKSGTSPKPWIFEISKLASGVPARFSG 63 Query: 277 -FQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPV 335 ++ L I ++ ++ Y CQ N T I P I +S + Sbjct: 64 SGSGTSYSLTISSMEAEDAAIYYCQQWNYPFTFGGGTKLEIKRADAAPTVSIFPPSSEQL 123 Query: 336 EDEDAVALTC-----------------EPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTL 378 ++ C E QN L +Q S + TL Sbjct: 124 TSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGV-LNSWTDQDSKDSTYSM----SSTL 177 Query: 379 TLLSVTRNDVGPYECGIQNKLSV 401 TL Y C +K S Sbjct: 178 TLTKDEYERHNSYTCEATHKTST 200 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 35/196 (17%), Positives = 62/196 (31%), Gaps = 37/196 (18%) Query: 419 TISPSYTYYRPGVNLSLSCHAASN--------------PPA---QYSWLIDGNIQQHTQE 461 T SP T G ++++C A+S+ P + S L G + + Sbjct: 5 TQSPDITAASLGQKVTITCSASSSVSYMHWYQQKSGTSPKPWIFEISKLASGVPARFSGS 64 Query: 462 -------LFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVE 514 L IS++ +++ +Y CQ N T I + P SI +S+ + Sbjct: 65 GSGTSYSLTISSMEAEDAAIYYCQQWNYPFTFGGGTKLEIKRADAAPTVSIFPPSSEQLT 124 Query: 515 DKDAVAFTCEPEAQNTT---YLWWVNGQSLPV---------SPRLQLSNGNRTLTLFNVT 562 + C W ++G + + + TLTL Sbjct: 125 SG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDE 183 Query: 563 RNDARAYVCGIQNSVS 578 +Y C + S Sbjct: 184 YERHNSYTCEATHKTS 199 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 33/201 (16%), Positives = 58/201 (28%), Gaps = 39/201 (19%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQ--------------NTTYLWWVNNQSLPVSPRLQ 370 S + V +TC +++ ++ + V R Sbjct: 3 VLTQSPDITAASLGQKVTITCSASSSVSYMHWYQQKSGTSPKPWIFEISKLASGVPARFS 62 Query: 371 LSNDNRT--LTLLSVTRNDVGPYECGIQNK-LSVDHSDPV-ILNVLYGPDDPTISPSYTY 426 S + LT+ S+ D Y C N + + I P PS Sbjct: 63 GSGSGTSYSLTISSMEAEDAAIYYCQQWNYPFTFGGGTKLEIKRADAAPTVSIFPPSSEQ 122 Query: 427 YRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFISN 466 G S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 123 LTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 181 Query: 467 ITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 182 DEYERHNSYTCEATHKTSTSP 202 Score = 37.6 bits (85), Expect = 0.018, Method: Composition-based stats. Identities = 34/190 (17%), Positives = 61/190 (32%), Gaps = 43/190 (22%) Query: 160 KDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRLQLSNGNRTLTL 202 V TC + +Y+ W +S +P S + +LT+ Sbjct: 16 GQKVTITCSASSS-VSYMHWYQQKSGTSPKPWIFEISKLASGVPARFSGSGSGTSYSLTI 74 Query: 203 FNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTSYRSGENLNLSC 259 ++ D A Y C+ N L + APT+S P + SG ++ C Sbjct: 75 SSMEAEDAAIYYCQQWNY-PFTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSG-GASVVC 132 Query: 260 HAASNPPAQY--SWFVNGTFQQS------------------TQELFIPNITVNNSGSYTC 299 + P W ++G+ +Q+ + L + SYTC Sbjct: 133 FLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTC 192 Query: 300 QAHNSDTGLN 309 +A + + Sbjct: 193 EATHKTSTSP 202 Score = 36.8 bits (83), Expect = 0.032, Method: Composition-based stats. Identities = 29/196 (14%), Positives = 56/196 (28%), Gaps = 37/196 (18%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSP----------------RLQL 549 S + V TC + + W+ P Sbjct: 6 QSPDITAASLGQKVTITCSASSSVSYMHWYQQKSGTSPKPWIFEISKLASGVPARFSGSG 65 Query: 550 SNGNRTLTLFNVTRNDARAYVCGIQN-SVSANRSDPVTLDVLYGPDTPIISPPDSSYLSG 608 S + +LT+ ++ DA Y C N + + + T I PP S L+ Sbjct: 66 SGTSYSLTISSMEAEDAAIYYCQQWNYPFTFGGGTKLEIKRADAAPTVSIFPPSSEQLTS 125 Query: 609 ANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKITPN 648 ++ C + + W+I+G +Q+ L + K Sbjct: 126 GGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYE 185 Query: 649 NNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 RHNSYTCEATHKTSTS 201 >1HKL-L nrPDB Length = 214 Score = 42.2 bits (97), Expect = 8e-04, Method: Composition-based stats. Identities = 30/196 (15%), Positives = 52/196 (26%), Gaps = 39/196 (19%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP + S GE ++L+C A+ W G Sbjct: 5 TQSPSSLSASLGERVSLTCRASQEINGYLGWLQQKPDGTIKRLIYAASTLHSGVPKRFSG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTC-QAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 + S L I ++ + Y C Q + T I P FI + Sbjct: 65 SRSGSDYSLTISSLESEDFADYYCLQYASYPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQ 124 Query: 335 VEDEDAVALTCEPEI--QNTTYLWWV----------NNQSLPVSPRLQLSNDNRTLTLLS 382 ++ ++ C + W + + + TLTL Sbjct: 125 LKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSK 183 Query: 383 VTRNDVGPYECGIQNK 398 Y C + ++ Sbjct: 184 ADYEKHKVYACEVTHQ 199 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 33/213 (15%), Positives = 67/213 (31%), Gaps = 26/213 (12%) Query: 149 ISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQL--------------- 193 S +S + V+ TC + YL W+ + RL Sbjct: 5 TQSPSSLSASLGERVSLTCRASQEINGYLGWLQQKPDGTIKRLIYAASTLHSGVPKRFSG 64 Query: 194 --SNGNRTLTLFNVTRNDTASYKCE--TQNPVSARRSDSVIL-NVLYGPDAPTISPLNTS 248 S + +LT+ ++ D A Y C P + V + + P P + Sbjct: 65 SRSGSDYSLTISSLESEDFADYYCLQYASYPRTFGGGTKVEIKRTVAAPSVFIFPPSDEQ 124 Query: 249 YRSGENLNLSCHAASNPP--AQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDT 306 +SG ++ C + P A+ W V+ Q + + +S +Y+ + + + Sbjct: 125 LKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTLS 182 Query: 307 GLNRTTVTTITVYAEPPKPFITSNNSNPVEDED 339 + E ++S + + Sbjct: 183 KADYEK--HKVYACEVTHQGLSSPVTKSFNRGE 213 >6DCW-L nrPDB Length = 220 Score = 41.8 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 34/212 (16%), Positives = 64/212 (30%), Gaps = 34/212 (16%) Query: 506 SSNNSKPVEDKDAVAFTCEPE--------------------AQNTTYLW-WVNGQSLPVS 544 S +S V + C+ Q L+ W + + VS Sbjct: 6 QSPDSLAVSLGERATINCKSSQSVFSRDNNKNYLAWYQHKSGQPPKLLFFWASSRESGVS 65 Query: 545 PRLQLSNG--NRTLTLFNVTRNDARAYVCG----IQNSVSANRSDPVTLDVLYGPDTPII 598 R S + TLT+ N+ D Y C ++ + V + I Sbjct: 66 DRFSGSGSGTDFTLTIDNLQAEDVALYYCQHYFNTPHNFGQGTKLEIKRTVAAP--SVFI 123 Query: 599 SPPDSSYLSGANLNLSCHSASNPS--PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACF 656 PP L ++ C + + W+++ Q + + ++ TY+ Sbjct: 124 FPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLS 182 Query: 657 VSNLATGRNNSIVKSITVSASGTSPGLSAGAT 688 + + + K + T GLS+ T Sbjct: 183 STLTLSKADYEKHKVY--ACEVTHQGLSSPVT 212 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 31/178 (17%), Positives = 61/178 (34%), Gaps = 12/178 (6%) Query: 170 ETQDATYLW-WVNNQSLPVSPRLQLSNGNR--TLTLFNVTRNDTASYKCETQNPVSARRS 226 Q L+ W +++ VS R S TLT+ N+ D A Y C+ Sbjct: 46 SGQPPKLLFFWASSRESGVSDRFSGSGSGTDFTLTIDNLQAEDVALYYCQHYFNTPHNFG 105 Query: 227 DSVILNVLYGPDAPTIS---PLNTSYRSGENLNLSCHAASNPP--AQYSWFVNGTFQQST 281 L + AP++ P + +SG ++ C + P A+ W V+ Q Sbjct: 106 QGTKLEIKRTVAAPSVFIFPPSDEQLKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGN 164 Query: 282 QELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDED 339 + + +S +Y+ + + + + E ++S + + Sbjct: 165 SQESVTEQDSKDS-TYSLSSTLTLSKADYEK--HKVYACEVTHQGLSSPVTKSFNRGE 219 Score = 39.2 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 26/180 (14%), Positives = 56/180 (31%), Gaps = 20/180 (11%) Query: 66 SWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVI 125 +WY+ + +++ + ++++ +SG + +L I N+ D Y Sbjct: 40 AWYQH-KSGQPPKLLFFWASSRESGVSDRFSGSGSGT-DFTLTIDNLQAEDVALYYCQHY 97 Query: 126 KSDLVN--EEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQD--ATYLWWVN 181 + N + + + P I + + ++ A A W V+ Sbjct: 98 FNTPHNFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVD 157 Query: 182 N---------QSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ-----NPVSARRSD 227 N + + + TLTL Y CE +PV+ + Sbjct: 158 NALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR 217 Score = 37.2 bits (84), Expect = 0.027, Method: Composition-based stats. Identities = 31/202 (15%), Positives = 58/202 (28%), Gaps = 45/202 (22%) Query: 419 TISPSYTYYRPGVNLSLSC--------------------HAASNPPAQ-YSW-------- 449 T SP G +++C H + PP + W Sbjct: 5 TQSPDSLAVSLGERATINCKSSQSVFSRDNNKNYLAWYQHKSGQPPKLLFFWASSRESGV 64 Query: 450 --LIDGNIQQHTQELFISNITEKNSGLYTCQAN-NSASGHSRTTVKTITVSAELPKPSIS 506 G+ L I N+ ++ LY CQ N+ + T I + P I Sbjct: 65 SDRFSGSGSGTDFTLTIDNLQAEDVALYYCQHYFNTPHNFGQGTKLEIKRTVAAPSVFIF 124 Query: 507 SNNSKPVEDKDAVAFTCEPEAQNT---TYLWWVNGQSLPVSPRLQLS---------NGNR 554 + + ++ + C W V+ + + ++ + + Sbjct: 125 PPSDEQLKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSS 183 Query: 555 TLTLFNVTRNDARAYVCGIQNS 576 TLTL + Y C + + Sbjct: 184 TLTLSKADYEKHKVYACEVTHQ 205 >4BSK-A nrPDB Length = 214 Score = 41.8 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 29/186 (15%), Positives = 54/186 (29%), Gaps = 24/186 (12%) Query: 27 FWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGT 86 + P T +T ES + + + QH ++W + G Sbjct: 3 YSMTPPTLNITEESHVIDTGDSLSISCR----GQHPLEWAWPGAQEAPATGDKDSEDTGV 58 Query: 87 QQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTL-----HVIKSDLVNEEATGQFRVY 141 + G + LL+ + NDTG Y + R + Sbjct: 59 VRDC-----EGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDF 113 Query: 142 PELPKPSISSNNSKPVEDKDAVAFTCE-------PETQDATYLWWVNNQSLPVSPRLQLS 194 + P I+ ++ V KDA+ C + + + W + Q + R + Sbjct: 114 EQ---PFINKPDTLLVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDGQEVVWDDRRGML 170 Query: 195 NGNRTL 200 L Sbjct: 171 VSTPLL 176 Score = 37.2 bits (84), Expect = 0.025, Method: Composition-based stats. Identities = 32/187 (17%), Positives = 67/187 (35%), Gaps = 27/187 (14%) Query: 235 YGPDAPT--ISPLNTSYRSGENLNLSCHAASNPPAQYSW-------------------FV 273 Y PT I+ + +G++L++SC P +++W Sbjct: 3 YSMTPPTLNITEESHVIDTGDSLSISCR--GQHPLEWAWPGAQEAPATGDKDSEDTGVVR 60 Query: 274 NGTFQQST---QELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPP-KPFITS 329 + + + L + + N++GSY C + TT + V+ +PFI Sbjct: 61 DCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPFINK 120 Query: 330 NNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVG 389 ++ V +DA+ + C I + L + + +D R + + + +D Sbjct: 121 PDTLLVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDAL 180 Query: 390 PYECGIQ 396 +C Sbjct: 181 YLQCETT 187 Score = 36.8 bits (83), Expect = 0.034, Method: Composition-based stats. Identities = 30/166 (18%), Positives = 54/166 (32%), Gaps = 34/166 (20%) Query: 413 YGPDDPTISPSYTYYR--PGVNLSLSCHAASNPPAQYSW--------------LIDGNIQ 456 Y PT++ + + G +LS+SC P +++W G ++ Sbjct: 3 YSMTPPTLNITEESHVIDTGDSLSISC--RGQHPLEWAWPGAQEAPATGDKDSEDTGVVR 60 Query: 457 QHTQE--------LFISNITEKNSGLYTCQANN-SASGHSRTTVKTITVSAELPKPSISS 507 L + + ++G Y C A T + + +P I+ Sbjct: 61 DCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPFINK 120 Query: 508 NNSKPVEDKDAVAFTC--EPEAQNTTYL-----WWVNGQSLPVSPR 546 ++ V KDA+ C N T W +GQ + R Sbjct: 121 PDTLLVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDGQEVVWDDR 166 Score = 32.6 bits (72), Expect = 0.55, Method: Composition-based stats. Identities = 22/131 (16%), Positives = 44/131 (33%), Gaps = 19/131 (14%) Query: 500 LPKPSISSNNSKPV-EDKDAVAFTCEPEAQNTTYLWWVNGQSLP------VSPRLQLSNG 552 + P+++ V + D+++ +C Q+ W Q P + + Sbjct: 5 MTPPTLNITEESHVIDTGDSLSISCR--GQHPLEWAWPGAQEAPATGDKDSEDTGVVRDC 62 Query: 553 NRT--------LTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDT--PIISPPD 602 T L L V ND +YVC + + ++ D P I+ PD Sbjct: 63 EGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPFINKPD 122 Query: 603 SSYLSGANLNL 613 + ++ + Sbjct: 123 TLLVNRKDAMW 133 >1A0Q-L nrPDB Length = 212 Score = 41.8 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 33/203 (16%), Positives = 53/203 (26%), Gaps = 48/203 (23%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWF-------------------------VNG 275 T SP + S G + ++C A+ + W+ G Sbjct: 5 TQSPSSLSASLGGKVTITCKASQDIKKYIGWYQHKPGKQPRLLIHYTSTLLPGIPSRFRG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPV 335 + I N+ + +Y C + + T I P I +S + Sbjct: 65 SGSGRDYSFSISNLEPEDIATYYCLQYYNLRTFGGGTKLEIKRADAAPTVSIFPPSSEQL 124 Query: 336 EDEDAVALTC-----------------EPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTL 378 ++ C E QN L +Q S + TL Sbjct: 125 TSG-GASVVCFLNNFYSKDINVKWKIDGSERQNGV-LNSWTDQDSKDSTYSM----SSTL 178 Query: 379 TLLSVTRNDVGPYECGIQNKLSV 401 TL Y C +K S Sbjct: 179 TLTKDEYERHNSYTCEATHKTST 201 Score = 38.0 bits (86), Expect = 0.016, Method: Composition-based stats. Identities = 27/163 (16%), Positives = 46/163 (28%), Gaps = 13/163 (7%) Query: 428 RPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHS 487 +PG L H S G+ ISN+ ++ Y C + Sbjct: 39 KPGKQPRLLIHYTSTLLPGIPSRFRGSGSGRDYSFSISNLEPEDIATYYCLQYYNLRTFG 98 Query: 488 RTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTT---YLWWVNGQSLPV- 543 T I + P SI +S+ + + C + W ++G Sbjct: 99 GGTKLEIKRADAAPTVSIFPPSSEQLTSG-GASVVCFLNNFYSKDINVKWKIDGSERQNG 157 Query: 544 --------SPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVS 578 + + + TLTL +Y C + S Sbjct: 158 VLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTS 200 Score = 37.2 bits (84), Expect = 0.024, Method: Composition-based stats. Identities = 35/203 (17%), Positives = 63/203 (31%), Gaps = 42/203 (20%) Query: 147 PSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS--------------LPVSPRLQ 192 S +S V TC+ Y+ W ++ LP P Sbjct: 3 ELTQSPSSLSASLGGKVTITCKASQDIKKYIGWYQHKPGKQPRLLIHYTSTLLPGIPSRF 62 Query: 193 LSNGNR---TLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLN 246 +G+ + ++ N+ D A+Y C Q L + APT+S P + Sbjct: 63 RGSGSGRDYSFSISNLEPEDIATYYC-LQYYNLRTFGGGTKLEIKRADAAPTVSIFPPSS 121 Query: 247 TSYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFI 286 SG ++ C + W ++G+ +Q+ + L + Sbjct: 122 EQLTSG-GASVVCFLNNFYSKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTL 180 Query: 287 PNITVNNSGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 181 TKDEYERHNSYTCEATHKTSTSP 203 Score = 36.5 bits (82), Expect = 0.045, Method: Composition-based stats. Identities = 32/202 (15%), Positives = 60/202 (29%), Gaps = 40/202 (19%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS-----------------LPVSP 367 S +S V +TC+ Y+ W ++ +P Sbjct: 3 ELTQSPSSLSASLGGKVTITCKASQDIKKYIGWYQHKPGKQPRLLIHYTSTLLPGIPSRF 62 Query: 368 RLQLSNDNRTLTLLSVTRNDVGPYECGI-QNKLSVDHSDPV-ILNVLYGPDDPTISPSYT 425 R S + + ++ ++ D+ Y C N + + I P PS Sbjct: 63 RGSGSGRDYSFSISNLEPEDIATYYCLQYYNLRTFGGGTKLEIKRADAAPTVSIFPPSSE 122 Query: 426 YYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFIS 465 G S+ C + + W IDG+ +Q+ + L ++ Sbjct: 123 QLTSG-GASVVCFLNNFYSKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLT 181 Query: 466 NITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 182 KDEYERHNSYTCEATHKTSTSP 203 >2DRU-A nrPDB Length = 180 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 21/128 (16%), Positives = 40/128 (31%), Gaps = 8/128 (6%) Query: 188 SPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNT 247 R+ L N L ++NV++ D Y + + + V P I Sbjct: 59 KDRVDLDKTNGALRIYNVSKEDRGDYY--MRMLHETEDQWKITMEVYEMVSKPMI----- 111 Query: 248 SYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTG 307 Y N L+C + + +S ++ + N + C+A N + Sbjct: 112 -YWECSNATLTCEVLEGTDVELKLYQGKEHLRSLRQKTMSYQWTNLRAPFKCKAVNRVSQ 170 Query: 308 LNRTTVTT 315 + V Sbjct: 171 ESEMEVVN 178 Score = 38.0 bits (86), Expect = 0.014, Method: Composition-based stats. Identities = 27/156 (17%), Positives = 51/156 (32%), Gaps = 18/156 (11%) Query: 76 NRQIIGYVIGTQQATPGPAYSGR-EIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEA 134 N++I+ Y ++ + R ++ N +L I N+ + D G Y + ++ + Sbjct: 39 NQKILEYFPNGKKTVFESVFKDRVDLDKTNGALRIYNVSKEDRGDYYMRMLHETEDQWKI 98 Query: 135 TGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLS 194 T + P + TCE L + S R + Sbjct: 99 TMEVYEMVSKP---------MIYWECSNATLTCEVLEGTDVELKLYQGKEHLRSLRQKTM 149 Query: 195 NGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVI 230 + T N+ +KC+ N VS V+ Sbjct: 150 SYQWT----NLRAP----FKCKAVNRVSQESEMEVV 177 Score = 33.4 bits (74), Expect = 0.39, Method: Composition-based stats. Identities = 28/191 (14%), Positives = 57/191 (29%), Gaps = 22/191 (11%) Query: 303 NSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS 362 N+ TG N T+T+ P + + + L P + T + ++ Sbjct: 10 NAITGSN----VTLTILKHPLASY---QRLTWLHTTNQKILEYFPNGKKTVFESVFKDRV 62 Query: 363 LPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISP 422 L N L + +V++ D G Y + ++ + + P Sbjct: 63 D-------LDKTNGALRIYNVSKEDRGDYYMRMLHETEDQWK------ITMEVYEMVSKP 109 Query: 423 SYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNS 482 + N +L+C + + ++ +S + C+A N Sbjct: 110 MIYWEC--SNATLTCEVLEGTDVELKLYQGKEHLRSLRQKTMSYQWTNLRAPFKCKAVNR 167 Query: 483 ASGHSRTTVKT 493 S S V Sbjct: 168 VSQESEMEVVN 178 Score = 32.6 bits (72), Expect = 0.64, Method: Composition-based stats. Identities = 16/73 (21%), Positives = 29/73 (39%), Gaps = 8/73 (10%) Query: 545 PRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSS 604 R+ L N L ++NV++ D Y + + +T++V P+I Sbjct: 60 DRVDLDKTNGALRIYNVSKEDRGDYYMRMLHET--EDQWKITMEVYEMVSKPMI------ 111 Query: 605 YLSGANLNLSCHS 617 Y +N L+C Sbjct: 112 YWECSNATLTCEV 124 >1A7O-L nrPDB Length = 106 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 18/85 (21%), Positives = 31/85 (36%), Gaps = 25/85 (29%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP + S GE + ++C A+ N +W+ G Sbjct: 5 TQSPASLSASVGETVTITCRASGNIHNYLAWYQQKQGKSPQLLVYYTTTLADGVPSRFSG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQ 300 + + L I ++ ++ GSY CQ Sbjct: 65 SGSGTQYSLKINSLQPDDFGSYYCQ 89 Score = 35.3 bits (79), Expect = 0.083, Method: Composition-based stats. Identities = 13/84 (15%), Positives = 22/84 (26%), Gaps = 17/84 (20%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTY-LWWVNG----------------QSLPVSPRLQ 548 S S + V TC Y W+ +P Sbjct: 6 QSPASLSASVGETVTITCRASGNIHNYLAWYQQKQGKSPQLLVYYTTTLADGVPSRFSGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCG 572 S +L + ++ +D +Y C Sbjct: 66 GSGTQYSLKINSLQPDDFGSYYCQ 89 Score = 34.5 bits (77), Expect = 0.16, Method: Composition-based stats. Identities = 15/83 (18%), Positives = 26/83 (31%), Gaps = 25/83 (30%) Query: 599 SPPDSSYLSGANLNLSCHSASNPSPQYSW-------------------------RINGIP 633 SP S G + ++C ++ N +W R +G Sbjct: 7 SPASLSASVGETVTITCRASGNIHNYLAWYQQKQGKSPQLLVYYTTTLADGVPSRFSGSG 66 Query: 634 QQHTQVLFIAKITPNNNGTYACF 656 L I + P++ G+Y C Sbjct: 67 SGTQYSLKINSLQPDDFGSYYCQ 89 Score = 30.7 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 16/85 (18%), Positives = 29/85 (34%), Gaps = 25/85 (29%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQYSWLI------------------DGNIQQHT- 459 T SP+ G ++++C A+ N +W DG + + Sbjct: 5 TQSPASLSASVGETVTITCRASGNIHNYLAWYQQKQGKSPQLLVYYTTTLADGVPSRFSG 64 Query: 460 ------QELFISNITEKNSGLYTCQ 478 L I+++ + G Y CQ Sbjct: 65 SGSGTQYSLKINSLQPDDFGSYYCQ 89 >1SEQ-L nrPDB Length = 213 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 35/201 (17%), Positives = 58/201 (28%), Gaps = 38/201 (18%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQ--------------NTTYLWWVNNQSLPVSPRLQ 370 S +V LTC ++ +N + V R Sbjct: 3 VLTQSPAIMSASLGSSVTLTCSASSSVSYMHWYQQKSGTSPVLLIYTTSNLASGVPSRFS 62 Query: 371 LSNDNRT--LTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYTY 426 S LT+ SV +D Y C + L + PT+S P + Sbjct: 63 GSGSGTFYSLTISSVEASDAADYYCHQWSSYPWTFGGGTKLEIKRADAAPTVSIFPPSSE 122 Query: 427 YRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFISN 466 S+ C + P + W IDG+ +Q+ + L ++ Sbjct: 123 QLTSGGASVVCFLNNFYPKSINSKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 182 Query: 467 ITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 183 NEYERHNSYTCEATHKTSTSP 203 Score = 38.8 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 35/195 (17%), Positives = 62/195 (31%), Gaps = 42/195 (21%) Query: 155 KPVEDKDAVAFTCEPETQDATYLWWVNNQSLP--------------VSPRLQLSNGNRT- 199 +V TC + +Y+ W +S P +G+ T Sbjct: 11 MSASLGSSVTLTCSASSS-VSYMHWYQQKSGTSPVLLIYTTSNLASGVPSRFSGSGSGTF 69 Query: 200 --LTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTSYRSGEN 254 LT+ +V +D A Y C + L + APT+S P + SG Sbjct: 70 YSLTISSVEASDAADYYCHQWSSYPWTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSG-G 128 Query: 255 LNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFIPNITVNNS 294 ++ C + P W ++G+ +Q+ + L + Sbjct: 129 ASVVCFLNNFYPKSINSKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKNEYERH 188 Query: 295 GSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 189 NSYTCEATHKTSTSP 203 Score = 38.0 bits (86), Expect = 0.015, Method: Composition-based stats. Identities = 31/197 (15%), Positives = 59/197 (29%), Gaps = 38/197 (19%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNG----------------QSLPVSPRLQL 549 S +V TC + + W+ +P Sbjct: 6 QSPAIMSASLGSSVTLTCSASSSVSYMHWYQQKSGTSPVLLIYTTSNLASGVPSRFSGSG 65 Query: 550 SNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSYLS 607 S +LT+ +V +DA Y C +S L++ P +S PP S L+ Sbjct: 66 SGTFYSLTISSVEASDAADYYCHQWSSYPWTFGGGTKLEIKRADAAPTVSIFPPSSEQLT 125 Query: 608 GANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKITP 647 ++ C + + W+I+G +Q+ L + K Sbjct: 126 SGGASVVCFLNNFYPKSINSKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKNEY 185 Query: 648 NNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 ERHNSYTCEATHKTSTS 202 >4YDV-L nrPDB Length = 265 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 36/218 (16%), Positives = 67/218 (30%), Gaps = 24/218 (11%) Query: 28 WNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQ 87 +P + A E + + +L +N +H +WY+ +R +++ Y + Sbjct: 51 QSPDSLAVSPGERATIHCKSSQTLLYSSNN--RHSI--AWYQ-QRPGQPPKLLLYWASMR 105 Query: 88 QATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVN--EEATGQFRVYPELP 145 + +SG + +L I N+ D Y H S + R P Sbjct: 106 LSGVPDRFSGSGSGT-DFTLTINNLQAEDVAIYYCHQYSSHPPTFGHGTRVELRRTVAAP 164 Query: 146 KPSISSNNSKPVEDKDAVAFTCEPETQD--ATYLWWVNN---------QSLPVSPRLQLS 194 I + + ++ A A W V+N + Sbjct: 165 SVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTY 224 Query: 195 NGNRTLTLFNVTRNDTASYKCETQ-----NPVSARRSD 227 + + TLTL Y CE +PV+ + Sbjct: 225 SLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR 262 Score = 38.8 bits (88), Expect = 0.009, Method: Composition-based stats. Identities = 28/180 (15%), Positives = 60/180 (33%), Gaps = 12/180 (6%) Query: 168 EPETQDATYLWWVNNQSLPVSPRLQLSNGNRT---LTLFNVTRNDTASYKCETQNPVSAR 224 + Q L + + L P +G+ T LT+ N+ D A Y C + Sbjct: 89 QRPGQPPKLLLYWASMRLSGVPDRFSGSGSGTDFTLTINNLQAEDVAIYYCHQYSSHPPT 148 Query: 225 RSDSVILNVLYGPDAPTIS---PLNTSYRSGENLNLSCHAASNPP--AQYSWFVNGTFQQ 279 + + AP++ P + +SG ++ C + P A+ W V+ Q Sbjct: 149 FGHGTRVELRRTVAAPSVFIFPPSDEQLKSG-TASVVCLLNNFYPREAKVQWKVDNALQS 207 Query: 280 STQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDED 339 + + +S +Y+ + + + + E ++S + + Sbjct: 208 GNSQESVTEQDSKDS-TYSLSSTLTLSKADYEK--HKVYACEVTHQGLSSPVTKSFNRGE 264 Score = 37.6 bits (85), Expect = 0.020, Method: Composition-based stats. Identities = 34/210 (16%), Positives = 61/210 (29%), Gaps = 30/210 (14%) Query: 506 SSNNSKPVEDKDAVAFTCEP--------------------EAQNTTYL--WWVNGQS-LP 542 S +S V + C+ Q L W S +P Sbjct: 51 QSPDSLAVSPGERATIHCKSSQTLLYSSNNRHSIAWYQQRPGQPPKLLLYWASMRLSGVP 110 Query: 543 VSPRLQLSNGNRTLTLFNVTRNDARAYVCG--IQNSVSANRSDPVTLDVLYGPDTPIISP 600 S + TLT+ N+ D Y C + + V L + I P Sbjct: 111 DRFSGSGSGTDFTLTINNLQAEDVAIYYCHQYSSHPPTFGHGTRVELRRTVAAPSVFIFP 170 Query: 601 PDSSYLSGANLNLSCHSASNPS--PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVS 658 P L ++ C + + W+++ Q + + ++ TY+ + Sbjct: 171 PSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSST 229 Query: 659 NLATGRNNSIVKSITVSASGTSPGLSAGAT 688 + + K + T GLS+ T Sbjct: 230 LTLSKADYEKHKVY--ACEVTHQGLSSPVT 257 Score = 33.8 bits (75), Expect = 0.30, Method: Composition-based stats. Identities = 33/229 (14%), Positives = 68/229 (29%), Gaps = 51/229 (22%) Query: 395 IQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHA------ASNPPAQYS 448 Q+ S+ + ++ YG SP PG ++ C + +SN + Sbjct: 26 TQSPASLAVPLLLWISGAYGDIVLAQSPDSLAVSPGERATIHCKSSQTLLYSSNNRHSIA 85 Query: 449 WLID------------------GNIQQHTQ-------ELFISNITEKNSGLYTCQANNSA 483 W G + + L I+N+ ++ +Y C + Sbjct: 86 WYQQRPGQPPKLLLYWASMRLSGVPDRFSGSGSGTDFTLTINNLQAEDVAIYYC---HQY 142 Query: 484 SGHSRT----TVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNT---TYLWWV 536 S H T T + + P I + + ++ + C W V Sbjct: 143 SSHPPTFGHGTRVELRRTVAAPSVFIFPPSDEQLKSG-TASVVCLLNNFYPREAKVQWKV 201 Query: 537 NGQSLPVSPRLQLS---------NGNRTLTLFNVTRNDARAYVCGIQNS 576 + + + ++ + + TLTL + Y C + + Sbjct: 202 DNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQ 250 >4GJT-B nrPDB Length = 123 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 22/111 (19%), Positives = 41/111 (36%), Gaps = 8/111 (7%) Query: 37 TIESTPFNVAEGKEVLLLVHNLPQHLFG-YSWYKGERVDGNRQIIGYVIGTQQATPGPAY 95 T + + + ++ G +W + + +G Q + + PAY Sbjct: 6 TSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEG-AQELALLHSKYGLHVSPAY 64 Query: 96 SGREIIYP------NASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRV 140 GR P + S+L++N +Q D G Y V + +A + RV Sbjct: 65 EGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRV 115 >1KEN-L nrPDB Length = 213 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 38/205 (18%), Positives = 63/205 (30%), Gaps = 44/205 (21%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTY-LWWVNNQSLPVSPRLQLSNDN-------- 375 S + V LTC T+ L+W + SP+L + + + Sbjct: 3 VLTQSPAIMSASPGEKVTLTCSASSTITSSFLYWYQQKP-GSSPKLWIYSTSNLASGVPA 61 Query: 376 ----------RTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS---P 422 +LT+ S+ D Y C L + PT+S P Sbjct: 62 RFSGSGSGTSYSLTISSLEAEDGASYFCHQWETFPRTFGGGTKLEIKRADAAPTVSIFPP 121 Query: 423 SYTYYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQEL 462 S G S+ C + P + W IDG+ +Q+ + L Sbjct: 122 SKIQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTL 180 Query: 463 FISNITEKNSGLYTCQANNSASGHS 487 ++ + YTC+A + S Sbjct: 181 TLTKDEYERHNSYTCEATHKTSTSP 205 Score = 37.2 bits (84), Expect = 0.025, Method: Composition-based stats. Identities = 37/205 (18%), Positives = 54/205 (26%), Gaps = 50/205 (24%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQY-SWFVNG------TFQQSTQ----------- 282 T SP S GE + L+C A+S + + W+ + ST Sbjct: 5 TQSPAIMSASPGEKVTLTCSASSTITSSFLYWYQQKPGSSPKLWIYSTSNLASGVPARFS 64 Query: 283 --------ELFIPNITVNNSGSYTCQAH-NSDTGLNRTTVTTITVYAEPPKPFITSNNSN 333 L I ++ + SY C T I P I + Sbjct: 65 GSGSGTSYSLTISSLEAEDGASYFCHQWETFPRTFGGGTKLEIKRADAAPTVSIFPPSKI 124 Query: 334 PVEDEDAVALTC-----------------EPEIQNTTYLWWVNNQSLPVSPRLQLSNDNR 376 + ++ C E QN L +Q S + Sbjct: 125 QLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGV-LNSWTDQDSKDSTYSM----SS 178 Query: 377 TLTLLSVTRNDVGPYECGIQNKLSV 401 TLTL Y C +K S Sbjct: 179 TLTLTKDEYERHNSYTCEATHKTST 203 Score = 36.1 bits (81), Expect = 0.059, Method: Composition-based stats. Identities = 33/196 (16%), Positives = 61/196 (31%), Gaps = 42/196 (21%) Query: 155 KPVEDKDAVAFTCEPET-QDATYLWWVNNQS-----------------LPVSPRLQLSNG 196 + V TC + +++L+W + +P S Sbjct: 11 MSASPGEKVTLTCSASSTITSSFLYWYQQKPGSSPKLWIYSTSNLASGVPARFSGSGSGT 70 Query: 197 NRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTSYRSGE 253 + +LT+ ++ D ASY C L + APT+S P SG Sbjct: 71 SYSLTISSLEAEDGASYFCHQWETFPRTFGGGTKLEIKRADAAPTVSIFPPSKIQLTSG- 129 Query: 254 NLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFIPNITVNN 293 ++ C + P W ++G+ +Q+ + L + Sbjct: 130 GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYER 189 Query: 294 SGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 190 HNSYTCEATHKTSTSP 205 Score = 29.9 bits (65), Expect = 4.4, Method: Composition-based stats. Identities = 28/199 (14%), Positives = 58/199 (29%), Gaps = 40/199 (20%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTT--YLWWVNG----------------QSLPVSPRL 547 S + V TC + T+ W+ +P Sbjct: 6 QSPAIMSASPGEKVTLTCSASSTITSSFLYWYQQKPGSSPKLWIYSTSNLASGVPARFSG 65 Query: 548 QLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS--PPDSSY 605 S + +LT+ ++ D +Y C + L++ P +S PP Sbjct: 66 SGSGTSYSLTISSLEAEDGASYFCHQWETFPRTFGGGTKLEIKRADAAPTVSIFPPSKIQ 125 Query: 606 LSGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKI 645 L+ ++ C + + W+I+G +Q+ L + K Sbjct: 126 LTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKD 185 Query: 646 TPNNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 EYERHNSYTCEATHKTSTS 204 >1HEZ-A nrPDB Length = 214 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 33/213 (15%), Positives = 68/213 (31%), Gaps = 26/213 (12%) Query: 149 ISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRL 191 S +S D V TC ++YL W + +P Sbjct: 5 TQSPSSLSASVGDRVTITCRTSQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSG 64 Query: 192 QLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTS 248 S + TLT+ ++ D A+Y C+ + + AP++ P + Sbjct: 65 SGSGTDFTLTISSLQPEDFATYYCQQSYSTPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQ 124 Query: 249 YRSGENLNLSCHAASNPP--AQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDT 306 +SG ++ C + P A+ W V+ Q + + +S +Y+ + + + Sbjct: 125 LKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTLS 182 Query: 307 GLNRTTVTTITVYAEPPKPFITSNNSNPVEDED 339 + E ++S + + Sbjct: 183 KADYEK--HKVYACEVTHQGLSSPVTKSFNRGE 213 Score = 41.1 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 34/195 (17%), Positives = 64/195 (32%), Gaps = 19/195 (9%) Query: 397 NKLSVDHSDPVILNVLYGPDDPTISPSYTYY--RPGVNLSLSCHAASNPPAQYSWLIDGN 454 + LS D V + +IS +Y +PG L +AAS+ + G+ Sbjct: 9 SSLSASVGDRVTITC---RTSQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGS 65 Query: 455 IQQHTQELFISNITEKNSGLYTCQANNSASGHSRT-TVKTITVSAELPKPSISSNNSKPV 513 L IS++ ++ Y CQ + S T I + P I + + + Sbjct: 66 GSGTDFTLTISSLQPEDFATYYCQQSYSTPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQL 125 Query: 514 EDKDAVAFTCEPEAQNT---TYLWWVNGQSLPVSPRLQLS---------NGNRTLTLFNV 561 + + C W V+ + + ++ + + TLTL Sbjct: 126 KSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKA 184 Query: 562 TRNDARAYVCGIQNS 576 + Y C + + Sbjct: 185 DYEKHKVYACEVTHQ 199 Score = 40.7 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 27/196 (13%), Positives = 56/196 (28%), Gaps = 39/196 (19%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP + S G+ + ++C + + + +W+ G Sbjct: 5 TQSPSSLSASVGDRVTITCRTSQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQAHNS-DTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 + + L I ++ + +Y CQ S + T I P FI + Sbjct: 65 SGSGTDFTLTISSLQPEDFATYYCQQSYSTPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQ 124 Query: 335 VEDEDAVALTCEPEI--QNTTYLWWV----------NNQSLPVSPRLQLSNDNRTLTLLS 382 ++ ++ C + W + + + TLTL Sbjct: 125 LKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSK 183 Query: 383 VTRNDVGPYECGIQNK 398 Y C + ++ Sbjct: 184 ADYEKHKVYACEVTHQ 199 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 37/213 (17%), Positives = 64/213 (30%), Gaps = 24/213 (11%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS---------------LPVSPRLQ 370 S +S D V +TC ++YL W + V R Sbjct: 4 MTQSPSSLSASVGDRVTITCRTSQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFS 63 Query: 371 LSNDNR--TLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNV---LYGPDDPTISPSYT 425 S TLT+ S+ D Y C + + + P PS Sbjct: 64 GSGSGTDFTLTISSLQPEDFATYYCQQSYSTPRTFGQGTKVEIKRTVAAPSVFIFPPSDE 123 Query: 426 YYRPGVNLSLSCHAASNP-PAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSAS 484 + G + P A+ W +D +Q + ++ K+S Y+ + + S Sbjct: 124 QLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTLS 182 Query: 485 GHSRTTVKTITVSAELPKPSISSNNSKPVEDKD 517 K + E+ +SS +K + Sbjct: 183 KADYEKHK--VYACEVTHQGLSSPVTKSFNRGE 213 Score = 37.2 bits (84), Expect = 0.026, Method: Composition-based stats. Identities = 27/180 (15%), Positives = 55/180 (30%), Gaps = 20/180 (11%) Query: 66 SWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVI 125 +WY+ ++ +++ Y + Q+ +SG + +L I ++ D Y Sbjct: 34 NWYQ-QKPGKAPKLLIYAASSLQSGVPSRFSGSGSGT-DFTLTISSLQPEDFATYYCQQS 91 Query: 126 KSDLVN--EEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQD--ATYLWWVN 181 S + + + P I + + ++ A A W V+ Sbjct: 92 YSTPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVD 151 Query: 182 N---------QSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ-----NPVSARRSD 227 N + + + TLTL Y CE +PV+ + Sbjct: 152 NALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR 211 >1ZVO-A nrPDB Length = 214 Score = 41.5 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 31/171 (18%), Positives = 53/171 (30%), Gaps = 25/171 (14%) Query: 170 ETQDATYLWWVNNQSLPVSPRLQL---SNGNRTLTLFNVTRNDTASYKCETQNPVSARRS 226 L + +NQ P S + +L + + D A Y C + Sbjct: 41 PGTTPKLLIYKDNQRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAAWDDSLWVFG 100 Query: 227 DSVILNVLYGPDAP---TISPLNTSYRSGENLNLSCHAASNPPA--QYSWFVNGTFQQST 281 L VL P A T+ P ++ L C + P +W + + ++ Sbjct: 101 GGTTLTVLSQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAG 160 Query: 282 QELFIPNITVNNS-----------------GSYTCQAHNSDTGLNRTTVTT 315 E P+ NN SY+CQ + + + +T T Sbjct: 161 VETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT 211 Score = 34.1 bits (76), Expect = 0.19, Method: Composition-based stats. Identities = 30/178 (16%), Positives = 51/178 (28%), Gaps = 14/178 (7%) Query: 519 VAFTCEPEAQNTTYLWWVNGQ---SLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQN 575 V + + L + + Q +P S + +L + + D Y C + Sbjct: 34 VYWYQQLPGTTPKLLIYKDNQRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAAWD 93 Query: 576 SVSANRSDPVTLDVLYGP---DTPIISPPDSSYLSGANLNLSCHSASNPS--PQYSWRIN 630 TL VL P + + PP S L L C + +W+ + Sbjct: 94 DSLWVFGGGTTLTVLSQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKAD 153 Query: 631 GIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKS----ITVSASGTSPGLS 684 P + NN YA T +S +T S ++ Sbjct: 154 SSPVKAGVETTTPSKQSNNK--YAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVA 209 >1SM3-L nrPDB Length = 215 Score = 41.1 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 28/201 (13%), Positives = 52/201 (25%), Gaps = 40/201 (19%) Query: 416 DDPTISPSYTYYRPGVNLSLSCHAAS----------------------------NPPAQY 447 D S PG ++L+C +++ N Sbjct: 1 DIVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRAPGV 60 Query: 448 SWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSIS- 506 G++ L I+ ++ +Y C S K + +E PS++ Sbjct: 61 PARFSGSLIGDKAALTITGAQTEDEAIYFCALWYSNHWVFGGGTKLTVLGSEKSSPSVTL 120 Query: 507 SNNSKPVEDKDAVAFTCEPEAQNTTYL---WWVNGQSLPV--SPRLQLSNGNRT------ 555 S + + C + W V+G + N Sbjct: 121 FPPSSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQPSKQSNNKYMASSY 180 Query: 556 LTLFNVTRNDARAYVCGIQNS 576 LTL +Y C + + Sbjct: 181 LTLTARAWERHSSYSCQVTHE 201 Score = 36.8 bits (83), Expect = 0.036, Method: Composition-based stats. Identities = 36/209 (17%), Positives = 51/209 (24%), Gaps = 31/209 (14%) Query: 505 ISSNNSKPVEDKDAVAFTCEPEAQNTT---YLWWVNGQS-----------------LPVS 544 ++ ++ + V TC T Y WV + +P Sbjct: 4 VTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRAPGVPAR 63 Query: 545 PRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTP---IISPP 601 L LT+ D Y C + S L VL + + PP Sbjct: 64 FSGSLIGDKAALTITGAQTEDEAIYFCALWYSNHWVFGGGTKLTVLGSEKSSPSVTLFPP 123 Query: 602 DSSYLSGANLNLSCHSASNPS--PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSN 659 S L L C W+++G P NN Y Sbjct: 124 SSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQPSKQSNNK--YMASSYL 181 Query: 660 LATGRNNSIVKS----ITVSASGTSPGLS 684 T R S +T LS Sbjct: 182 TLTARAWERHSSYSCQVTHEGHTVEKSLS 210 Score = 35.3 bits (79), Expect = 0.083, Method: Composition-based stats. Identities = 26/198 (13%), Positives = 53/198 (26%), Gaps = 44/198 (22%) Query: 243 SPLNTSYRSGENLNLSCHAA----------------------------SNPPAQYSWFVN 274 + GE + L+C ++ +N + Sbjct: 6 QESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRAPGVPARFS 65 Query: 275 GTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGL--NRTTVTTITVYAEPPKPFITSNNS 332 G+ L I + Y C S+ + T +T + P + +S Sbjct: 66 GSLIGDKAALTITGAQTEDEAIYFCALWYSNHWVFGGGTKLTVLGSEKSSPSVTLFPPSS 125 Query: 333 NPVEDEDAVALTCEPE--IQNTTYLWWVNNQSLPVSPRLQLSND----------NRTLTL 380 +E L C + W + PV+ ++ + + LTL Sbjct: 126 EELETNK-ATLVCTITDFYPGVVTVDWKVDG-TPVTQGMETTQPSKQSNNKYMASSYLTL 183 Query: 381 LSVTRNDVGPYECGIQNK 398 + Y C + ++ Sbjct: 184 TARAWERHSSYSCQVTHE 201 Score = 28.8 bits (62), Expect = 9.5, Method: Composition-based stats. Identities = 31/153 (20%), Positives = 49/153 (32%), Gaps = 16/153 (10%) Query: 81 GYVIGTQQATPG-PA-YSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQF 138 G + GT PG PA +SG +I A+L I D Y + S+ + Sbjct: 48 GLIGGTNNRAPGVPARFSGS-LIGDKAALTITGAQTEDEAIYFCALWYSNHWVFGGGTKL 106 Query: 139 RVYPEL---PKPSISSNNSKPVEDKDAVAFTCEPETQD--ATYLWWVNNQSL-------- 185 V P ++ +S+ +E A + T W V+ + Sbjct: 107 TVLGSEKSSPSVTLFPPSSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQ 166 Query: 186 PVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ 218 P + LTL +SY C+ Sbjct: 167 PSKQSNNKYMASSYLTLTARAWERHSSYSCQVT 199 >1KCS-L nrPDB Length = 214 Score = 41.1 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 40/200 (20%), Positives = 62/200 (31%), Gaps = 41/200 (20%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS-----------------LPVSP 367 S S + +AV L C+ TY+ W + +P Sbjct: 3 VMTQSPKSMGMSVGEAVTLNCKASENVGTYVSWYQQKPGQSPVLLIYGASNRYTGVPDRF 62 Query: 368 RLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS---PSY 424 S + TLT+ SV +D Y CG + L + PT S PS Sbjct: 63 TGSGSATDFTLTISSVQADDDADYYCGQSYSSPLTFGGGTKLELKRADAAPTSSIFPPSS 122 Query: 425 TYYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQHTQ------------------ELFI 464 G S+ C S P + W +DG+ + + L + Sbjct: 123 EQLSSG-GASVVCFLNSFYPKSIAVKWKVDGSKRANGTANSWTDQDSASSTYSMSSTLTL 181 Query: 465 SNITEKNSGLYTCQANNSAS 484 + + YTC+A + S Sbjct: 182 TKDKYERHNSYTCEATHKTS 201 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 32/189 (16%), Positives = 60/189 (31%), Gaps = 39/189 (20%) Query: 160 KDAVAFTCEPETQDATYLWWVNNQS-------LPVSPRLQL----------SNGNRTLTL 202 +AV C+ TY+ W + + + S + TLT+ Sbjct: 16 GEAVTLNCKASENVGTYVSWYQQKPGQSPVLLIYGASNRYTGVPDRFTGSGSATDFTLTI 75 Query: 203 FNVTRNDTASYKC--ETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCH 260 +V +D A Y C +P++ + L +I P ++ S ++ C Sbjct: 76 SSVQADDDADYYCGQSYSSPLTFGGGTKLELKRADAAPTSSIFPPSSEQLSSGGASVVCF 135 Query: 261 AASNPPAQYS--WFVNGTFQ------------------QSTQELFIPNITVNNSGSYTCQ 300 S P + W V+G+ + + L + SYTC+ Sbjct: 136 LNSFYPKSIAVKWKVDGSKRANGTANSWTDQDSASSTYSMSSTLTLTKDKYERHNSYTCE 195 Query: 301 AHNSDTGLN 309 A + + Sbjct: 196 ATHKTSSSP 204 Score = 36.5 bits (82), Expect = 0.041, Method: Composition-based stats. Identities = 32/197 (16%), Positives = 56/197 (28%), Gaps = 37/197 (18%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP + GE + L+C A+ N SW+ G Sbjct: 5 TQSPKSMGMSVGEAVTLNCKASENVGTYVSWYQQKPGQSPVLLIYGASNRYTGVPDRFTG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTC-QAHNSDTGLNRTTVTTIT-VYAEPPKPFITSNNSN 333 + + L I ++ ++ Y C Q+++S T + A P ++ Sbjct: 65 SGSATDFTLTISSVQADDDADYYCGQSYSSPLTFGGGTKLELKRADAAPTSSIFPPSSEQ 124 Query: 334 PVEDEDAVALTCEPEIQNTTYLWWVNNQS----------LPVSPRLQLSNDNRTLTLLSV 383 +V + + W + S + + TLTL Sbjct: 125 LSSGGASVVCFLNSFYPKSIAVKWKVDGSKRANGTANSWTDQDSASSTYSMSSTLTLTKD 184 Query: 384 TRNDVGPYECGIQNKLS 400 Y C +K S Sbjct: 185 KYERHNSYTCEATHKTS 201 Score = 33.0 bits (73), Expect = 0.52, Method: Composition-based stats. Identities = 34/198 (17%), Positives = 57/198 (28%), Gaps = 39/198 (19%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQYSWL------------------IDGNIQQHTQ 460 T SP G ++L+C A+ N SW G + T Sbjct: 5 TQSPKSMGMSVGEAVTLNCKASENVGTYVSWYQQKPGQSPVLLIYGASNRYTGVPDRFTG 64 Query: 461 -------ELFISNITEKNSGLYTCQANNSAS-GHSRTTVKTITVSAELPKPSISSNNSKP 512 L IS++ + Y C + S+ T + + P SI +S+ Sbjct: 65 SGSATDFTLTISSVQADDDADYYCGQSYSSPLTFGGGTKLELKRADAAPTSSIFPPSSEQ 124 Query: 513 VEDKDAVAFTCEPEAQNT---TYLWWVNGQSLPVSPRLQLSNGN---------RTLTLFN 560 + + C + W V+G ++ + TLTL Sbjct: 125 LSSG-GASVVCFLNSFYPKSIAVKWKVDGSKRANGTANSWTDQDSASSTYSMSSTLTLTK 183 Query: 561 VTRNDARAYVCGIQNSVS 578 +Y C + S Sbjct: 184 DKYERHNSYTCEATHKTS 201 >1MF2-L nrPDB Length = 215 Score = 41.1 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 33/206 (16%), Positives = 60/206 (29%), Gaps = 43/206 (20%) Query: 325 PFITSNNSNPVEDEDAVALTC-------------------EPEIQNTTYLWWVNNQSLPV 365 S S V ++C +P ++ +NQ V Sbjct: 3 VLTQSPASLAVSLGQRATISCRASESVDYYGKSFMNWFQQKPGQPPKLLIYAASNQGSGV 62 Query: 366 SPRLQLSNDNR--TLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS-- 421 R S +L + + +D Y C ++ L + PT+S Sbjct: 63 PARFSGSGSGTDFSLHIHPMEEDDSAMYFCQQSKEVPWTFGGGTKLEIKRADAAPTVSIF 122 Query: 422 PSYTYYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQE 461 P + S+ C + P + W IDG+ +Q+ + Sbjct: 123 PPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSST 182 Query: 462 LFISNITEKNSGLYTCQANNSASGHS 487 L ++ + YTC+A + S Sbjct: 183 LTLTKDEYERHNSYTCEATHKTSTSP 208 Score = 39.2 bits (89), Expect = 0.007, Method: Composition-based stats. Identities = 30/166 (18%), Positives = 55/166 (33%), Gaps = 27/166 (16%) Query: 170 ETQDATYLWWVNNQSLPVSPRLQLSNGNRT---LTLFNVTRNDTASYKCETQNPVSARRS 226 Q L + + P +G+ T L + + +D+A Y C+ V Sbjct: 44 PGQPPKLLIYAASNQGSGVPARFSGSGSGTDFSLHIHPMEEDDSAMYFCQQSKEVPWTFG 103 Query: 227 DSVILNVLYGPDAPTIS---PLNTSYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS- 280 L + APT+S P + SG ++ C + P W ++G+ +Q+ Sbjct: 104 GGTKLEIKRADAAPTVSIFPPSSEQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNG 162 Query: 281 -----------------TQELFIPNITVNNSGSYTCQAHNSDTGLN 309 + L + SYTC+A + + Sbjct: 163 VLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSP 208 >4OIB-A nrPDB Length = 378 Score = 41.1 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 53/379 (13%), Positives = 107/379 (28%), Gaps = 51/379 (13%) Query: 321 EPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDN----- 375 EP + VE ++ L C L S R + Sbjct: 1 EPFWADLQ-PRVAFVERGGSLWLNCSTNCPRP------ERGGLETSLRRNGTQRGLRWLA 53 Query: 376 -RTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLS 434 + + + V + C + ++ PD + P + G N + Sbjct: 54 RQLVDIREPETQPVCFFRCARRT-----LQARGLIRTFQRPDRVELMPLPPWQPVGENFT 108 Query: 435 LSCHAASNPPAQ-------------YSWLIDGNIQQHTQELFISNI--TEKNSG-LYTCQ 478 LSC P G + + + + ++ G ++C+ Sbjct: 109 LSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEPPRARGAVLTATVLARREDHGANFSCR 168 Query: 479 ANNSASGH-------SRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTT 531 A H S + T S P +++ V + V +C + Sbjct: 169 AELDLRPHGLGLFENSSAPRELRTFSLSPDAPRLAAPRLLEVGSERPV--SCTLDGLFPA 226 Query: 532 --YLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRND---ARAYVCGIQNSVSANRSDPVT 586 ++ +SP + L T + AR VC + NR Sbjct: 227 SEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGARQLVCNVT-LGGENRETREN 285 Query: 587 LDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKIT 646 + + P P+++ + S G + ++C + + +P Q Q L + Sbjct: 286 VTIYSFP-APLLTLSEPSVSEGQMVTVTCAAGAQALVTLEGVPAAVPGQPAQ-LQLNATE 343 Query: 647 PNNNGTYACFVSNLATGRN 665 ++ ++ C + G Sbjct: 344 NDDRRSFFCDATLDVDGET 362 >2JB5-L nrPDB Length = 216 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 29/162 (17%), Positives = 49/162 (30%), Gaps = 14/162 (8%) Query: 429 PGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHS- 487 PG L + SN P+ S G+ +T L IS + ++ Y C++ +S +S Sbjct: 42 PGKAPKLMIYGGSNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCRSWDSNLSYSV 101 Query: 488 --RTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNT---TYLWWVNGQSLP 542 T T+ + S + C T W + + Sbjct: 102 FGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVK 161 Query: 543 --VSPRLQLSNGNRT------LTLFNVTRNDARAYVCGIQNS 576 V N L+L R+Y C + + Sbjct: 162 AGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHE 203 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 39/212 (18%), Positives = 68/212 (32%), Gaps = 44/212 (20%) Query: 148 SISSNNSKPVEDKDAVAFTCEPETQDA---TYLWWV---------------NNQSLPVSP 189 +++ S ++ +C + D Y+ W +N+ VS Sbjct: 3 ALTQPASVSGSPGQSITISCTGTSSDVGSNNYVSWYQQHPGKAPKLMIYGGSNRPSGVSN 62 Query: 190 RLQLSNGNRT--LTLFNVTRNDTASYKCET--QNPVSARRSDSVILNVLYGPDAP---TI 242 R S T LT+ + D A Y C + N + L VL P A T+ Sbjct: 63 RFSGSKSGNTASLTISGLQAEDEADYYCRSWDSNLSYSVFGGGTKLTVLGQPKAAPSVTL 122 Query: 243 SPLNTSYRSGENLNLSCHAASNPPA--QYSWFVNGTFQQSTQELFIPNITVNNS------ 294 P ++ L C + P +W + + ++ E P+ NN Sbjct: 123 FPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSY 182 Query: 295 -----------GSYTCQAHNSDTGLNRTTVTT 315 SY+CQ + + + +T T Sbjct: 183 LSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT 214 Score = 34.5 bits (77), Expect = 0.17, Method: Composition-based stats. Identities = 25/146 (17%), Positives = 53/146 (36%), Gaps = 10/146 (6%) Query: 251 SGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLN- 309 G+ L + SN P+ S +G+ +T L I + + Y C++ +S+ + Sbjct: 42 PGKAPKLMIYGGSNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCRSWDSNLSYSV 101 Query: 310 RTTVTTITVYAEP---PKPFITSNNSNPVEDEDAVALTCEPEIQNTT-YLWWVNNQSLPV 365 T +TV +P P + +S ++ A + + + W + Sbjct: 102 FGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKAD----- 156 Query: 366 SPRLQLSNDNRTLTLLSVTRNDVGPY 391 S ++ + T + S + Y Sbjct: 157 SSPVKAGVETTTPSKQSNNKYAASSY 182 Score = 33.0 bits (73), Expect = 0.47, Method: Composition-based stats. Identities = 36/211 (17%), Positives = 65/211 (30%), Gaps = 44/211 (20%) Query: 327 ITSNNSNPVEDEDAVALTC---EPEIQNTTYLWWV---------------NNQSLPVSPR 368 +T S ++ ++C ++ + Y+ W +N+ VS R Sbjct: 4 LTQPASVSGSPGQSITISCTGTSSDVGSNNYVSWYQQHPGKAPKLMIYGGSNRPSGVSNR 63 Query: 369 LQLS--NDNRTLTLLSVTRNDVGPYECGI--QNKLSVDHSDPVILNVLYGPDD---PTIS 421 S + +LT+ + D Y C N L VL P T+ Sbjct: 64 FSGSKSGNTASLTISGLQAEDEADYYCRSWDSNLSYSVFGGGTKLTVLGQPKAAPSVTLF 123 Query: 422 PSYTYYRPGVNLSLSCHAAS-NPPA-QYSWLIDGNIQQ-----------------HTQEL 462 P + +L C + P A +W D + + + L Sbjct: 124 PPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYL 183 Query: 463 FISNITEKNSGLYTCQANNSASGHSRTTVKT 493 ++ K+ Y+CQ + S +T T Sbjct: 184 SLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT 214 >4XNY-L nrPDB Length = 211 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 32/203 (15%), Positives = 58/203 (28%), Gaps = 25/203 (12%) Query: 506 SSNNSKPVEDKDAVAFTCEPE---------------AQNTTYLW---WVNGQSLPVSPRL 547 S + V + +C P Q L + +P Sbjct: 6 QSPGTLSVSPGERATLSCRPSQAISKSHLAWYSQKSGQPPRLLLTGTYERASGVPDRFVG 65 Query: 548 QLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLS 607 S N TLT+ +V D Y C + V + I PP L Sbjct: 66 SGSGTNYTLTIASVEAEDFAVYFCQCFEGFGQGTKLEIKRTVAAP--SVFIFPPSDEQLK 123 Query: 608 GANLNLSCHSASNPS--PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRN 665 ++ C + + W+++ Q + + ++ TY+ + + + Sbjct: 124 SGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTLSKAD 182 Query: 666 NSIVKSITVSASGTSPGLSAGAT 688 K + T GLS+ T Sbjct: 183 YEKHKVY--ACEVTHQGLSSPVT 203 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 31/206 (15%), Positives = 62/206 (30%), Gaps = 25/206 (12%) Query: 154 SKPVEDKDAVAFTCEPETQDATY--LWWVNNQSLPVS-------------PRLQLSNG-- 196 + V + +C P + W+ P P + +G Sbjct: 10 TLSVSPGERATLSCRPSQAISKSHLAWYSQKSGQPPRLLLTGTYERASGVPDRFVGSGSG 69 Query: 197 -NRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENL 255 N TLT+ +V D A Y C+ + V P P + +SG Sbjct: 70 TNYTLTIASVEAEDFAVYFCQCFEGFGQGTKLEIKRTVA-APSVFIFPPSDEQLKSG-TA 127 Query: 256 NLSCHAASNPP--AQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTV 313 ++ C + P A+ W V+ Q + + +S +Y+ + + + + Sbjct: 128 SVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTLSKADYEK- 185 Query: 314 TTITVYAEPPKPFITSNNSNPVEDED 339 E ++S + + Sbjct: 186 -HKVYACEVTHQGLSSPVTKSFNRGE 210 Score = 37.6 bits (85), Expect = 0.018, Method: Composition-based stats. Identities = 31/196 (15%), Positives = 57/196 (29%), Gaps = 42/196 (21%) Query: 419 TISPSYTYYRPGVNLSLSCHA---------------ASNPP-----AQYSW------LID 452 T SP PG +LSC + PP Y Sbjct: 5 TQSPGTLSVSPGERATLSCRPSQAISKSHLAWYSQKSGQPPRLLLTGTYERASGVPDRFV 64 Query: 453 GNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKP 512 G+ L I+++ ++ +Y CQ G + T I + P I + + Sbjct: 65 GSGSGTNYTLTIASVEAEDFAVYFCQC---FEGFGQGTKLEIKRTVAAPSVFIFPPSDEQ 121 Query: 513 VEDKDAVAFTCEPEAQNT---TYLWWVNGQSLPVSPRLQLS---------NGNRTLTLFN 560 ++ + C W V+ + + ++ + + TLTL Sbjct: 122 LKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSK 180 Query: 561 VTRNDARAYVCGIQNS 576 + Y C + + Sbjct: 181 ADYEKHKVYACEVTHQ 196 Score = 33.8 bits (75), Expect = 0.28, Method: Composition-based stats. Identities = 26/178 (14%), Positives = 49/178 (27%), Gaps = 20/178 (11%) Query: 66 SWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVI 125 +WY + R ++ P + G N +L I ++ D Y Sbjct: 35 AWYSQKSGQPPRLLLTGTYERASGVPD-RFVGSGSGT-NYTLTIASVEAEDFAVYFCQCF 92 Query: 126 KSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQD--ATYLWWVNN- 182 + + + + P I + + ++ A A W V+N Sbjct: 93 EGFGQGTK--LEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNA 150 Query: 183 --------QSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ-----NPVSARRSD 227 + + + TLTL Y CE +PV+ + Sbjct: 151 LQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR 208 >2ZNW-A nrPDB Length = 242 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 37/218 (16%), Positives = 61/218 (27%), Gaps = 38/218 (17%) Query: 34 AKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGP 93 LT +V G V L WY+ + + R +I Y + P Sbjct: 2 IVLTQSPATLSVTPGNSVSLSCRASQSIGNNLHWYQQKSHESPRLLIKYASQSISGIPS- 60 Query: 94 AYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPS----- 148 +SG + +L I ++ D G Y S + + Sbjct: 61 RFSGSGSGT-DFTLSINSVETEDFGMYFCQQSNSWPYTFGGGTKLEITGGGGSGGGGSGG 119 Query: 149 ------ISSNNSKPVEDKDAVAFTCEPETQDAT--YLWWVNNQS---------------- 184 + + V+ ++ TC T Y W+ Sbjct: 120 GGSDIQLQESGPSLVKPSQTLSLTCSVTGDSITSDYWSWIRKFPGNRLEYMGYVSYSGST 179 Query: 185 ---LPVSPRLQL----SNGNRTLTLFNVTRNDTASYKC 215 + R+ + S L L +VT DTA+Y C Sbjct: 180 YYNPSLKSRISITRDTSKNQYYLDLNSVTTEDTATYYC 217 Score = 39.2 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 32/160 (20%), Positives = 49/160 (30%), Gaps = 33/160 (20%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQL------------- 371 S + V ++V+L+C L W +S SPRL + Sbjct: 3 VLTQSPATLSVTPGNSVSLSCRASQSIGNNLHWYQQKSH-ESPRLLIKYASQSISGIPSR 61 Query: 372 -----SNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVL------------YG 414 S + TL++ SV D G Y C N L + G Sbjct: 62 FSGSGSGTDFTLSINSVETEDFGMYFCQQSNSWPYTFGGGTKLEITGGGGSGGGGSGGGG 121 Query: 415 PDDPTISPSYTYYRPGVNLSLSCHAASNPPAQ--YSWLID 452 D + +P LSL+C + +SW+ Sbjct: 122 SDIQLQESGPSLVKPSQTLSLTCSVTGDSITSDYWSWIRK 161 Score = 37.2 bits (84), Expect = 0.025, Method: Composition-based stats. Identities = 28/152 (18%), Positives = 47/152 (30%), Gaps = 35/152 (23%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP S G +++LSC A+ + W+ G Sbjct: 5 TQSPATLSVTPGNSVSLSCRASQSIGNNLHWYQQKSHESPRLLIKYASQSISGIPSRFSG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQAHNS----DTGLNRTTVTTITVYAEPPKPFITSNN 331 + + L I ++ + G Y CQ NS G + +T S+ Sbjct: 65 SGSGTDFTLSINSVETEDFGMYFCQQSNSWPYTFGGGTKLEITGGGGSGGGGSGGGGSDI 124 Query: 332 SNP------VEDEDAVALTCEPEIQNTTYLWW 357 V+ ++LTC + T +W Sbjct: 125 QLQESGPSLVKPSQTLSLTCSVTGDSITSDYW 156 Score = 34.9 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 37/213 (17%), Positives = 67/213 (31%), Gaps = 60/213 (28%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQYSWL------------------IDGNIQQHTQ 460 T SP+ PG ++SLSC A+ + W I G + + Sbjct: 5 TQSPATLSVTPGNSVSLSCRASQSIGNNLHWYQQKSHESPRLLIKYASQSISGIPSRFSG 64 Query: 461 -------ELFISNITEKNSGLYTCQANNS----ASGHSRTTVKTITVSAELPKP------ 503 L I+++ ++ G+Y CQ +NS G ++ + S Sbjct: 65 SGSGTDFTLSINSVETEDFGMYFCQQSNSWPYTFGGGTKLEITGGGGSGGGGSGGGGSDI 124 Query: 504 SISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLP--------------------- 542 + + V+ ++ TC + T +W + P Sbjct: 125 QLQESGPSLVKPSQTLSLTCSVTGDSITSDYWSWIRKFPGNRLEYMGYVSYSGSTYYNPS 184 Query: 543 VSPRLQLSNGNRT----LTLFNVTRNDARAYVC 571 + R+ ++ L L +VT D Y C Sbjct: 185 LKSRISITRDTSKNQYYLDLNSVTTEDTATYYC 217 Score = 29.9 bits (65), Expect = 4.1, Method: Composition-based stats. Identities = 19/87 (21%), Positives = 30/87 (34%), Gaps = 25/87 (28%) Query: 599 SPPDSSYLSGANLNLSCHSASNPSPQYSWR------------------INGIPQQHTQ-- 638 SP S G +++LSC ++ + W I+GIP + + Sbjct: 7 SPATLSVTPGNSVSLSCRASQSIGNNLHWYQQKSHESPRLLIKYASQSISGIPSRFSGSG 66 Query: 639 -----VLFIAKITPNNNGTYACFVSNL 660 L I + + G Y C SN Sbjct: 67 SGTDFTLSINSVETEDFGMYFCQQSNS 93 >5NQK-B nrPDB Length = 251 Score = 40.7 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 27/160 (16%), Positives = 49/160 (30%), Gaps = 32/160 (20%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVN--GQSLPVSPRLQLSN------------ 551 S ++ V +CE + W+ GQ L + Q+ N Sbjct: 5 QSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIVNDFQKGDIAEGYS 64 Query: 552 ------GNRTLTLFNVTRNDARAYVC----GIQNSVSANRSDPVTLDVL------YGPDT 595 + LT+ + +N Y+C G+ + + L VL + P+ Sbjct: 65 VSREKKESFPLTVTSAQKNPTAFYLCASSQGLAGAGELFFGEGSRLTVLEDLKNVFPPEV 124 Query: 596 PIISPPDSSYLSGANLNLSCHSASNPSPQY--SWRINGIP 633 + P ++ L C + SW +NG Sbjct: 125 AVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKE 164 >1LIL-A nrPDB Length = 212 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 30/193 (15%), Positives = 59/193 (30%), Gaps = 28/193 (14%) Query: 203 FNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAA 262 +V+ TA C + V + P SP+ Y+ + Sbjct: 9 LSVSPGQTARITCSGE--------KLGDAYVCWYQQRPGQSPVVVIYQDNR------RPS 54 Query: 263 SNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEP 322 P +G+ +T L I + Y CQ +S+ + T +TV +P Sbjct: 55 GIPE-----RFSGSSSGNTATLTISGTQTLDEADYYCQVWDSNASVVFGGGTKLTVLGQP 109 Query: 323 ---PKPFITSNNSNPVEDEDAVALTCEPEIQNTT-YLWWVNNQSLPVSPRLQLSNDNRTL 378 P + +S ++ A + + + W + S ++ + T Sbjct: 110 KAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKAD-----SSPVKAGVETTTP 164 Query: 379 TLLSVTRNDVGPY 391 + S + Y Sbjct: 165 SKQSNNKYAASSY 177 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 38/208 (18%), Positives = 61/208 (29%), Gaps = 40/208 (19%) Query: 148 SISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-------LPVSPRL--------- 191 ++ S V TC E Y+ W + + R Sbjct: 2 EVTQPPSLSVSPGQTARITCSGEKLGDAYVCWYQQRPGQSPVVVIYQDNRRPSGIPERFS 61 Query: 192 -QLSNGNRTLTLFNVTRNDTASYKCET-QNPVSARRSDSVILNVLYGPDAP---TISPLN 246 S TLT+ D A Y C+ + S L VL P A T+ P + Sbjct: 62 GSSSGNTATLTISGTQTLDEADYYCQVWDSNASVVFGGGTKLTVLGQPKAAPSVTLFPPS 121 Query: 247 TSYRSGENLNLSCHAASNPPA--QYSWFVNGTFQQSTQELFIPNITVNNS---------- 294 + L C + P +W + + ++ E P+ NN Sbjct: 122 SEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLT 181 Query: 295 -------GSYTCQAHNSDTGLNRTTVTT 315 SY+CQ + + + +T T Sbjct: 182 PEQWKSHRSYSCQVTHEGSTVEKTVAPT 209 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 26/163 (15%), Positives = 46/163 (28%), Gaps = 13/163 (7%) Query: 427 YRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQA--NNSAS 484 RPG + + + + P+ G+ +T L IS + Y CQ +N++ Sbjct: 36 QRPGQSPVVVIYQDNRRPSGIPERFSGSSSGNTATLTISGTQTLDEADYYCQVWDSNASV 95 Query: 485 GHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNT---TYLWWVNGQSL 541 T T+ + S + C T W + + Sbjct: 96 VFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPV 155 Query: 542 P--VSPRLQLSNGNRT------LTLFNVTRNDARAYVCGIQNS 576 V N L+L R+Y C + + Sbjct: 156 KAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHE 198 Score = 36.1 bits (81), Expect = 0.055, Method: Composition-based stats. Identities = 37/207 (17%), Positives = 62/207 (29%), Gaps = 40/207 (19%) Query: 327 ITSNNSNPVEDEDAVALTCE---------------PEIQNTTYLWWVNNQSLPVSPRLQL 371 +T S V +TC P ++ N + + R Sbjct: 3 VTQPPSLSVSPGQTARITCSGEKLGDAYVCWYQQRPGQSPVVVIYQDNRRPSGIPERFSG 62 Query: 372 SN--DNRTLTLLSVTRNDVGPYECGI-QNKLSVDHSDPVILNVLYGPDD---PTISPSYT 425 S+ + TLT+ D Y C + + SV L VL P T+ P + Sbjct: 63 SSSGNTATLTISGTQTLDEADYYCQVWDSNASVVFGGGTKLTVLGQPKAAPSVTLFPPSS 122 Query: 426 YYRPGVNLSLSCHAAS-NPPA-QYSWLIDGNIQQ-----------------HTQELFISN 466 +L C + P A +W D + + + L ++ Sbjct: 123 EELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTP 182 Query: 467 ITEKNSGLYTCQANNSASGHSRTTVKT 493 K+ Y+CQ + S +T T Sbjct: 183 EQWKSHRSYSCQVTHEGSTVEKTVAPT 209 Score = 35.7 bits (80), Expect = 0.067, Method: Composition-based stats. Identities = 34/207 (16%), Positives = 58/207 (28%), Gaps = 29/207 (14%) Query: 505 ISSNNSKPVEDKDAVAFTC--------------EPEAQNTTYLWWVNGQ---SLPVSPRL 547 ++ S V TC + Q+ + + + + +P Sbjct: 3 VTQPPSLSVSPGQTARITCSGEKLGDAYVCWYQQRPGQSPVVVIYQDNRRPSGIPERFSG 62 Query: 548 QLSNGNRTLTLFNVTRNDARAYVCGI-QNSVSANRSDPVTLDVLYGP---DTPIISPPDS 603 S TLT+ D Y C + ++ S L VL P + + PP S Sbjct: 63 SSSGNTATLTISGTQTLDEADYYCQVWDSNASVVFGGGTKLTVLGQPKAAPSVTLFPPSS 122 Query: 604 SYLSGANLNLSCHSASNPS--PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLA 661 L L C + +W+ + P + NN YA Sbjct: 123 EELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNK--YAASSYLSL 180 Query: 662 TGRNNSIVKS----ITVSASGTSPGLS 684 T +S +T S ++ Sbjct: 181 TPEQWKSHRSYSCQVTHEGSTVEKTVA 207 >4HIX-L nrPDB Length = 220 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 32/211 (15%), Positives = 64/211 (30%), Gaps = 15/211 (7%) Query: 140 VYPELPKPSISSNNSKPVEDKDAVA----FTCEPETQDATYLWWVNNQSLPVSPRLQLSN 195 SIS +S+ + D D +P ++ V+ V R S Sbjct: 13 PVTPGEPASISCKSSQSLLDSDGKTYLNWLLQKPGQSPQRLIYLVSKLDSGVPDRFSGSG 72 Query: 196 GNR--TLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTSYR 250 TL + V D Y C + + AP++ P + + Sbjct: 73 SGTDFTLKISRVEAEDVGVYYCWQGTHFPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLK 132 Query: 251 SGENLNLSCHAASNPP--AQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGL 308 SG ++ C + P A+ W V+ Q + + +S +Y+ + + + Sbjct: 133 SG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTLSKA 190 Query: 309 NRTTVTTITVYAEPPKPFITSNNSNPVEDED 339 + E ++S + + Sbjct: 191 DYEK--HKVYACEVTHQGLSSPVTKSFNRGE 219 Score = 39.9 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 36/219 (16%), Positives = 65/219 (29%), Gaps = 29/219 (13%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEI----------------------QNTTYLWWVNNQS 362 S S PV + +++C+ Q YL + Sbjct: 4 VMTQSPLSLPVTPGEPASISCKSSQSLLDSDGKTYLNWLLQKPGQSPQRLIYLVSKLDSG 63 Query: 363 LPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNV---LYGPDDPT 419 +P S + TL + V DVG Y C + + + P Sbjct: 64 VPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPRTFGQGTKVEIKRTVAAPSVFI 123 Query: 420 ISPSYTYYRPGVNLSLSCHAASNP-PAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQ 478 PS + G + P A+ W +D +Q + ++ K+S Y+ Sbjct: 124 FPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLS 182 Query: 479 ANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKD 517 + + S K + E+ +SS +K + Sbjct: 183 STLTLSKADYEKHK--VYACEVTHQGLSSPVTKSFNRGE 219 Score = 36.5 bits (82), Expect = 0.041, Method: Composition-based stats. Identities = 33/211 (15%), Positives = 67/211 (31%), Gaps = 12/211 (5%) Query: 487 SRTTVKTITVSAELPKP-SISSNNSKPVEDKDA-VAFTCEPEAQNTTYLWW---VNGQSL 541 + ++ V+ P S S+ S D + + + Q+ L + + Sbjct: 5 MTQSPLSLPVTPGEPASISCKSSQSLLDSDGKTYLNWLLQKPGQSPQRLIYLVSKLDSGV 64 Query: 542 PVSPRLQLSNGNRTLTLFNVTRNDARAYVC--GIQNSVSANRSDPVTLDVLYGPDTPIIS 599 P S + TL + V D Y C G + + V + + I Sbjct: 65 PDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPRTFGQGTKVEIKRTVAAPSVFIF 124 Query: 600 PPDSSYLSGANLNLSCHSASNPS--PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFV 657 PP L ++ C + + W+++ Q + + ++ TY+ Sbjct: 125 PPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSS 183 Query: 658 SNLATGRNNSIVKSITVSASGTSPGLSAGAT 688 + + + K + T GLS+ T Sbjct: 184 TLTLSKADYEKHKVY--ACEVTHQGLSSPVT 212 >3OAI-A nrPDB Length = 507 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 18/100 (18%), Positives = 37/100 (37%), Gaps = 5/100 (5%) Query: 222 SARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQST 281 S SD + Y P+ + Y G+ + W G + Sbjct: 412 SEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYI---DEVGTFKERIQW--VGDPRWKD 466 Query: 282 QELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAE 321 + I N+ +++G++TC N + +T+ T+ V+ + Sbjct: 467 GSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEK 506 Score = 36.1 bits (81), Expect = 0.053, Method: Composition-based stats. Identities = 18/94 (19%), Positives = 34/94 (36%), Gaps = 5/94 (5%) Query: 403 HSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQEL 462 SD + Y P+ + S +Y G + W+ G+ + + Sbjct: 415 VSDDISFTWRYQPEGGRDAISIFHYAKGQPYI---DEVGTFKERIQWV--GDPRWKDGSI 469 Query: 463 FISNITEKNSGLYTCQANNSASGHSRTTVKTITV 496 I N+ ++G +TC N +T+ T+ V Sbjct: 470 VIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYV 503 Score = 35.7 bits (80), Expect = 0.080, Method: Composition-based stats. Identities = 17/89 (19%), Positives = 34/89 (38%), Gaps = 7/89 (7%) Query: 63 FGYSW-YKGERVDGNRQIIGYVIGTQQATPGPAYSGREI-----IYPNASLLIQNIIQND 116 ++W Y+ E I Y G + R + + S++I N+ +D Sbjct: 419 ISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPRWKDGSIVIHNLDYSD 478 Query: 117 TGFYTLHVIK-SDLVNEEATGQFRVYPEL 144 G +T V D+V + + V+ ++ Sbjct: 479 NGTFTCDVKNPPDIVGKTSQVTLYVFEKV 507 Score = 33.0 bits (73), Expect = 0.45, Method: Composition-based stats. Identities = 11/52 (21%), Positives = 21/52 (40%), Gaps = 4/52 (7%) Query: 625 YSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLAT--GRNNSIVKSITV 674 W G P+ + I + ++NGT+ C V N G+ + + + Sbjct: 456 IQWV--GDPRWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFE 505 >7FAB-L nrPDB Length = 208 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 35/186 (18%), Positives = 61/186 (32%), Gaps = 26/186 (13%) Query: 152 NNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTA 211 +S + V + + L + NN VS S + TL + + D A Sbjct: 24 GSSSNIGAGHNVKWYQQLPGTAPKLLIFHNNARFSVSK----SGTSATLAITGLQAEDEA 79 Query: 212 SYKCETQNPVSARRSDSVILNVLYGPDAP---TISPLNTSYRSGENLNLSCHAASNPPA- 267 Y C++ + L VL P A T+ P ++ L C + P Sbjct: 80 DYYCQSYDRSLRVFGGGTKLTVLRQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGA 139 Query: 268 -QYSWFVNGTFQQSTQELFIPNITVNNS-----------------GSYTCQAHNSDTGLN 309 +W + + ++ E P+ NN SY+CQ + + + Sbjct: 140 VTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVE 199 Query: 310 RTTVTT 315 +T T Sbjct: 200 KTVAPT 205 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 33/186 (17%), Positives = 52/186 (27%), Gaps = 15/186 (8%) Query: 508 NNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDAR 567 +S + V + + L + N VS S + TL + + D Sbjct: 24 GSSSNIGAGHNVKWYQQLPGTAPKLLIFHNNARFSVSK----SGTSATLAITGLQAEDEA 79 Query: 568 AYVCGIQNSVSANRSDPVTLDVLYGP---DTPIISPPDSSYLSGANLNLSCHSASNPS-- 622 Y C + L VL P + + PP S L L C + Sbjct: 80 DYYCQSYDRSLRVFGGGTKLTVLRQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGA 139 Query: 623 PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKS----ITVSASG 678 +W+ + P + NN YA T KS +T S Sbjct: 140 VTVAWKADSSPVKAGVETTTPSKQSNNK--YAASSYLSLTPEQWKSHKSYSCQVTHEGST 197 Query: 679 TSPGLS 684 ++ Sbjct: 198 VEKTVA 203 >1H3P-L nrPDB Length = 240 Score = 40.3 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 37/208 (17%), Positives = 70/208 (33%), Gaps = 29/208 (13%) Query: 129 LVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVA--FTCEPETQDATYLWWVNNQSLP 186 + ++ V ++ SS + + + F +P ++W + + Sbjct: 4 MTQSPSSLAVSVGEKVTMSCRSSQSLLNTRTRKSYLAWFQQKPGQSPKMLIYWASTRESG 63 Query: 187 VSPRLQLSNGNR--TLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS- 243 V R S TLT+ +V D A Y C+ Q+ L + APT+S Sbjct: 64 VPDRFTGSGSGTDFTLTISSVQAEDLAVYYCK-QSYSLYTFGGGTKLEIKRADAAPTVSI 122 Query: 244 --PLNTSYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQS------------------T 281 P + SG ++ C + P W ++G+ +Q+ + Sbjct: 123 FPPSSEQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMS 181 Query: 282 QELFIPNITVNNSGSYTCQAHNSDTGLN 309 L + SYTC+A + + Sbjct: 182 STLTLTKDEYERHNSYTCEATHKTSTSP 209 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 33/203 (16%), Positives = 59/203 (29%), Gaps = 44/203 (21%) Query: 419 TISPSYTYYRPGVNLSLSCHAASN---------------------PPAQYSW---LIDGN 454 T SPS G +++SC ++ + P W G Sbjct: 5 TQSPSSLAVSVGEKVTMSCRSSQSLLNTRTRKSYLAWFQQKPGQSPKMLIYWASTRESGV 64 Query: 455 IQQHTQ-------ELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISS 507 + T L IS++ ++ +Y C+ + S T I + P SI Sbjct: 65 PDRFTGSGSGTDFTLTISSVQAEDLAVYYCKQSYSLYTFGGGTKLEIKRADAAPTVSIFP 124 Query: 508 NNSKPVEDKDAVAFTCEPEAQNTT---YLWWVNGQSLPV---------SPRLQLSNGNRT 555 +S+ + + C W ++G + + + T Sbjct: 125 PSSEQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSST 183 Query: 556 LTLFNVTRNDARAYVCGIQNSVS 578 LTL +Y C + S Sbjct: 184 LTLTKDEYERHNSYTCEATHKTS 206 >1HDM-B nrPDB Length = 193 Score = 39.9 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 16/82 (19%), Positives = 30/82 (36%), Gaps = 8/82 (9%) Query: 502 KPSISSNNSKPVEDKDAVAFTCEPEAQNT---TYLWWVNGQSLPVSPRLQLSNGNR---- 554 PS+ + P ++ V C T W NG+ + S + + N Sbjct: 90 PPSVQVAKTTPFNTREPVMLACYVWGFYPAEVTITWRKNGKLVMHSSAHKTAQPNGDWTY 149 Query: 555 -TLTLFNVTRNDARAYVCGIQN 575 TL+ +T + Y C +++ Sbjct: 150 QTLSHLALTPSYGDTYTCVVEH 171 Score = 33.0 bits (73), Expect = 0.52, Method: Composition-based stats. Identities = 13/89 (14%), Positives = 24/89 (26%), Gaps = 16/89 (17%) Query: 415 PDDPTISPSYTYYRPGVNLSLSCHAASNPPA--QYSWLIDGNIQQHTQ------------ 460 T + + L+C+ PA +W +G + H+ Sbjct: 89 RPPSVQVAKTTPFNTREPVMLACYVWGFYPAEVTITWRKNGKLVMHSSAHKTAQPNGDWT 148 Query: 461 --ELFISNITEKNSGLYTCQANNSASGHS 487 L +T YTC + + Sbjct: 149 YQTLSHLALTPSYGDTYTCVVEHIGAPEP 177 Score = 32.2 bits (71), Expect = 0.79, Method: Composition-based stats. Identities = 20/103 (19%), Positives = 36/103 (34%), Gaps = 17/103 (16%) Query: 572 GIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSP--QYSWRI 629 G+QN + + +L P + ++ + + + + L+C+ +WR Sbjct: 69 GLQNCATHTQPFWGSLTNRTRPPSVQVAKT-TPFNTREPVMLACYVWGFYPAEVTITWRK 127 Query: 630 NGIPQQH--------------TQVLFIAKITPNNNGTYACFVS 658 NG H Q L +TP+ TY C V Sbjct: 128 NGKLVMHSSAHKTAQPNGDWTYQTLSHLALTPSYGDTYTCVVE 170 >1SVZ-A nrPDB Length = 247 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 27/215 (12%), Positives = 63/215 (29%), Gaps = 42/215 (19%) Query: 42 PFNVAEGKEVLLLVHNLPQHLFGYS---WYKGERVDGNRQIIGYVIGTQQATPGPAYSGR 98 P ++ + + H G + WY ++ + Q++ Y + + + +SG Sbjct: 12 PVSLGDQASISCRSSQTIVHNNGNTYLEWYL-QKPGQSPQLLIYKVSNRFSGVPDRFSGS 70 Query: 99 EIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRV-----------YPELPKP 147 + +L I + D G Y + + + Sbjct: 71 GSGT-DFTLKISRVEAEDLGIYYCFQGSHFPPTFGGGTKLEIKGGGGSGGGGSGGGGSEV 129 Query: 148 SISSNNSKPVEDKDAVAFTC----------------EPETQDATYLWWVNNQSLPVS--- 188 + + + + + V +C + D Y+ W+N ++ + Sbjct: 130 QLQQSGPELKKPGETVKISCKATNYAFTDYSMHWVKQAPGGDLKYVGWINTETDEPTFAD 189 Query: 189 --PRLQLSN-----GNRTLTLFNVTRNDTASYKCE 216 + L + N+ DTA+Y C Sbjct: 190 DFKGRFAFSLDTSTSTAFLQINNLKNEDTATYFCV 224 Score = 36.8 bits (83), Expect = 0.032, Method: Composition-based stats. Identities = 33/221 (14%), Positives = 57/221 (25%), Gaps = 68/221 (30%) Query: 326 FITSNNSNPVEDEDAVALTCEP-----EIQNTTYLWWV---------------NNQSLPV 365 + PV D +++C TYL W +N+ V Sbjct: 4 MTQTPLYLPVSLGDQASISCRSSQTIVHNNGNTYLEWYLQKPGQSPQLLIYKVSNRFSGV 63 Query: 366 SPRLQLSNDNR--TLTLLSVTRNDVGPYEC------------GIQNKLSVDHSDPVILNV 411 R S TL + V D+G Y C G + ++ + Sbjct: 64 PDRFSGSGSGTDFTLKISRVEAEDLGIYYCFQGSHFPPTFGGGTKLEIKGGGGSGGGGSG 123 Query: 412 LYGPDDPTISPSYTYYRPGVNLSLSCHAASNP---------------------------- 443 G + +PG + +SC A + Sbjct: 124 GGGSEVQLQQSGPELKKPGETVKISCKATNYAFTDYSMHWVKQAPGGDLKYVGWINTETD 183 Query: 444 PAQYSWLIDGNIQ------QHTQELFISNITEKNSGLYTCQ 478 ++ G T L I+N+ +++ Y C Sbjct: 184 EPTFADDFKGRFAFSLDTSTSTAFLQINNLKNEDTATYFCV 224 Score = 35.3 bits (79), Expect = 0.095, Method: Composition-based stats. Identities = 32/213 (15%), Positives = 49/213 (23%), Gaps = 68/213 (31%) Query: 156 PVEDKDAVAFTCE-----PETQDATYLWWVNNQS-------LPVSPRLQL---------- 193 PV D + +C TYL W + + Sbjct: 12 PVSLGDQASISCRSSQTIVHNNGNTYLEWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSG 71 Query: 194 SNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNV------------LYGPDAPT 241 S + TL + V D Y C + L + G + Sbjct: 72 SGTDFTLKISRVEAEDLGIYYCFQGSHFPPTFGGGTKLEIKGGGGSGGGGSGGGGSEVQL 131 Query: 242 ISPLNTSYRSGENLNLSCHAASNPPAQY--SWFVN---------GTFQQSTQE------- 283 + GE + +SC A + Y W G T E Sbjct: 132 QQSGPELKKPGETVKISCKATNYAFTDYSMHWVKQAPGGDLKYVGWINTETDEPTFADDF 191 Query: 284 ----------------LFIPNITVNNSGSYTCQ 300 L I N+ ++ +Y C Sbjct: 192 KGRFAFSLDTSTSTAFLQINNLKNEDTATYFCV 224 >1UWX-K nrPDB Length = 213 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 33/202 (16%), Positives = 57/202 (28%), Gaps = 39/202 (19%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS---------------LPVSPRL 369 + S ++V +TC T+L W + V R Sbjct: 3 VMTQTPASQSASLGESVTITCLASQTIGTWLAWYQQKPGKSPQLLIYAATSLADGVPSRF 62 Query: 370 QLSNDNR--TLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTIS--PSYT 425 S + + S+ D Y C + L + PT+S P + Sbjct: 63 SGSGSGTKFSFKISSLQAEDFVSYYCQQLSSTPYTFGGGTKLEIKRADAAPTVSIFPPSS 122 Query: 426 YYRPGVNLSLSCHAASNPPAQYS--WLIDGNIQQH------------------TQELFIS 465 S+ C + P + W IDG +Q+ + L ++ Sbjct: 123 EQLTSGGASVVCFLNNFYPKDINVKWKIDGKERQNGVLNSWTDQDSKDSTYSMSSTLTLT 182 Query: 466 NITEKNSGLYTCQANNSASGHS 487 + YTC+A + S Sbjct: 183 KDEYERHNSYTCEATHKTSTSP 204 Score = 31.4 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 32/202 (15%), Positives = 57/202 (28%), Gaps = 45/202 (22%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T +P + S GE++ ++C A+ +W+ G Sbjct: 5 TQTPASQSASLGESVTITCLASQTIGTWLAWYQQKPGKSPQLLIYAATSLADGVPSRFSG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQA-----HNSDTGLN---RTTVTTITVYAEPPKPF- 326 + + I ++ + SY CQ + G + TV PP Sbjct: 65 SGSGTKFSFKISSLQAEDFVSYYCQQLSSTPYTFGGGTKLEIKRADAAPTVSIFPPSSEQ 124 Query: 327 -------ITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLT 379 + +N + V + + + L +Q S + TLT Sbjct: 125 LTSGGASVVCFLNNFYPKDINVKWKIDGKERQNGVLNSWTDQDSKDSTYSM----SSTLT 180 Query: 380 LLSVTRNDVGPYECGIQNKLSV 401 L Y C +K S Sbjct: 181 LTKDEYERHNSYTCEATHKTST 202 >3NVQ-A nrPDB Length = 590 Score = 39.9 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 20/89 (22%), Positives = 33/89 (37%), Gaps = 1/89 (1%) Query: 143 ELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTL 202 PKP + + +C E++ ATY W + +++ S + N L + Sbjct: 498 PNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATY-SWRHKENVEQSCEPGHQSPNCILFI 556 Query: 203 FNVTRNDTASYKCETQNPVSARRSDSVIL 231 N+T Y CE Q R + L Sbjct: 557 ENLTAQQYGHYFCEAQEGSYFREAQHWQL 585 Score = 33.8 bits (75), Expect = 0.29, Method: Composition-based stats. Identities = 20/118 (16%), Positives = 32/118 (27%), Gaps = 3/118 (2%) Query: 471 NSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNT 530 + G ++ S PKP + + +C E+++ Sbjct: 470 DQGRCISIYSSERSVLQSINPAEPHKECPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHA 529 Query: 531 TYLWW-VNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTL 587 TY W P Q N L + N+T Y C Q + L Sbjct: 530 TYSWRHKENVEQSCEPGHQSPNC--ILFIENLTAQQYGHYFCEAQEGSYFREAQHWQL 585 Score = 33.4 bits (74), Expect = 0.33, Method: Composition-based stats. Identities = 27/107 (25%), Positives = 33/107 (30%), Gaps = 17/107 (15%) Query: 209 DTASYKCETQNPVSARRSDSVILNVLYGPDAPTISP-----LNTSYRSGENLNLSCHAAS 263 D +C S R I + P P S LSC S Sbjct: 470 DQG--RC-ISIYSSERSVLQSINPAEPHKECPNPKPDKAPLQKVSLAPNSRYYLSCPMES 526 Query: 264 NPPAQYSWFVNGTFQQSTQE--------LFIPNITVNNSGSYTCQAH 302 A YSW +QS + LFI N+T G Y C+A Sbjct: 527 R-HATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQYGHYFCEAQ 572 Score = 33.0 bits (73), Expect = 0.45, Method: Composition-based stats. Identities = 21/94 (22%), Positives = 35/94 (37%), Gaps = 7/94 (7%) Query: 309 NRTTVTTITVYAEP------PKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS 362 + +V AEP PKP + L+C E ++ TY W + ++ Sbjct: 480 SERSVLQSINPAEPHKECPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATY-SWRHKEN 538 Query: 363 LPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQ 396 + S + N L + ++T G Y C Q Sbjct: 539 VEQSCEPGHQSPNCILFIENLTAQQYGHYFCEAQ 572 Score = 31.8 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 21/73 (28%), Positives = 26/73 (35%), Gaps = 9/73 (12%) Query: 415 PDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQH--------TQELFISN 466 P P LSC S A YSW N++Q LFI N Sbjct: 500 PKPDKAPLQKVSLAPNSRYYLSCPMESR-HATYSWRHKENVEQSCEPGHQSPNCILFIEN 558 Query: 467 ITEKNSGLYTCQA 479 +T + G Y C+A Sbjct: 559 LTAQQYGHYFCEA 571 >1NEU-A nrPDB Length = 124 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 18/102 (17%), Positives = 40/102 (39%), Gaps = 5/102 (4%) Query: 222 SARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQST 281 S SD + Y P+ + Y G+ + W + +++ Sbjct: 26 SEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYI---DEVGTFKERIQWVGDPSWK--D 80 Query: 282 QELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPP 323 + I N+ +++G++TC N + +T+ T+ V+ + P Sbjct: 81 GSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVP 122 Score = 36.5 bits (82), Expect = 0.044, Method: Composition-based stats. Identities = 19/99 (19%), Positives = 36/99 (36%), Gaps = 5/99 (5%) Query: 403 HSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQEL 462 SD + Y P+ + S +Y G + W+ G+ + Sbjct: 29 VSDDISFTWRYQPEGGRDAISIFHYAKGQPYI---DEVGTFKERIQWV--GDPSWKDGSI 83 Query: 463 FISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELP 501 I N+ ++G +TC N +T+ T+ V ++P Sbjct: 84 VIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVP 122 Score = 36.1 bits (81), Expect = 0.058, Method: Composition-based stats. Identities = 18/92 (19%), Positives = 35/92 (38%), Gaps = 7/92 (7%) Query: 63 FGYSW-YKGERVDGNRQIIGYVIGTQQATPGPAYSGREI-----IYPNASLLIQNIIQND 116 ++W Y+ E I Y G + R + + S++I N+ +D Sbjct: 33 ISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPSWKDGSIVIHNLDYSD 92 Query: 117 TGFYTLHVIK-SDLVNEEATGQFRVYPELPKP 147 G +T V D+V + + V+ ++P Sbjct: 93 NGTFTCDVKNPPDIVGKTSQVTLYVFEKVPTR 124 Score = 31.8 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 11/56 (19%), Positives = 20/56 (35%), Gaps = 4/56 (7%) Query: 625 YSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLAT--GRNNSIVKSITVSASG 678 W G P + I + ++NGT+ C V N G+ + + + Sbjct: 70 IQWV--GDPSWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVPT 123 >4XMP-L nrPDB Length = 211 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 28/196 (14%), Positives = 50/196 (25%), Gaps = 42/196 (21%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQY-SWFVN------------------------- 274 T SP S GE + LSC + ++ W Sbjct: 5 TQSPAILSVSLGERVTLSCKTSQAITPRHLVWHRQKGGQAPSLVMTGTSERASGIPDRFI 64 Query: 275 GTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 G+ + L I + + Y CQ + + I P FI + Sbjct: 65 GSGSGTDFTLTITRLEAEDFAVYYCQCLEAFGQGTK---LEIKRTVAAPSVFIFPPSDEQ 121 Query: 335 VEDEDAVALTCEPEI--QNTTYLWWV----------NNQSLPVSPRLQLSNDNRTLTLLS 382 ++ ++ C + W + + + TLTL Sbjct: 122 LKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSK 180 Query: 383 VTRNDVGPYECGIQNK 398 Y C + ++ Sbjct: 181 ADYEKHKVYACEVTHQ 196 Score = 38.8 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 33/203 (16%), Positives = 61/203 (30%), Gaps = 25/203 (12%) Query: 506 SSNNSKPVEDKDAVAFTCEPE-AQNTTYLWW---VNGQ--------------SLPVSPRL 547 S V + V +C+ A +L W GQ +P Sbjct: 6 QSPAILSVSLGERVTLSCKTSQAITPRHLVWHRQKGGQAPSLVMTGTSERASGIPDRFIG 65 Query: 548 QLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLS 607 S + TLT+ + D Y C + + V + I PP L Sbjct: 66 SGSGTDFTLTITRLEAEDFAVYYCQCLEAFGQGTKLEIKRTVAAP--SVFIFPPSDEQLK 123 Query: 608 GANLNLSCHSASNPS--PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRN 665 ++ C + + W+++ Q + + ++ TY+ + + + Sbjct: 124 SGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTLSKAD 182 Query: 666 NSIVKSITVSASGTSPGLSAGAT 688 K + T GLS+ T Sbjct: 183 YEKHKVY--ACEVTHQGLSSPVT 203 Score = 35.7 bits (80), Expect = 0.080, Method: Composition-based stats. Identities = 28/209 (13%), Positives = 58/209 (27%), Gaps = 34/209 (16%) Query: 380 LLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHA 439 +LSV+ + C ++ H P S A Sbjct: 10 ILSVSLGERVTLSCKTSQAITPRHLVWHRQKGGQAPSLVMTGTSE-------------RA 56 Query: 440 ASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAE 499 + P G+ L I+ + ++ +Y CQ + + T I + Sbjct: 57 SGIPD-----RFIGSGSGTDFTLTITRLEAEDFAVYYCQCLEAFG---QGTKLEIKRTVA 108 Query: 500 LPKPSISSNNSKPVEDKDAVAFTCEPEAQNT---TYLWWVNGQSLPVSPRLQLS------ 550 P I + + ++ + C W V+ + + ++ Sbjct: 109 APSVFIFPPSDEQLKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKD 167 Query: 551 ---NGNRTLTLFNVTRNDARAYVCGIQNS 576 + + TLTL + Y C + + Sbjct: 168 STYSLSSTLTLSKADYEKHKVYACEVTHQ 196 Score = 34.9 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 32/207 (15%), Positives = 60/207 (28%), Gaps = 31/207 (14%) Query: 42 PFNVAEGKEVLLLVHN--LPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGRE 99 ++ E + P+HL W+ R G + + GT + G R Sbjct: 12 SVSLGERVTLSCKTSQAITPRHLV---WH---RQKGGQAPSLVMTGTSERASG--IPDRF 63 Query: 100 IIYPNAS---LLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKP 156 I + + L I + D Y +++ + + + P I + + Sbjct: 64 IGSGSGTDFTLTITRLEAEDFAVYYCQCLEAFGQGTK--LEIKRTVAAPSVFIFPPSDEQ 121 Query: 157 VEDKDAVAFTCEPETQD--ATYLWWVNN---------QSLPVSPRLQLSNGNRTLTLFNV 205 ++ A A W V+N + + + TLTL Sbjct: 122 LKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKA 181 Query: 206 TRNDTASYKCETQ-----NPVSARRSD 227 Y CE +PV+ + Sbjct: 182 DYEKHKVYACEVTHQGLSSPVTKSFNR 208 >1MIM-L nrPDB Length = 210 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 33/211 (15%), Positives = 68/211 (32%), Gaps = 25/211 (11%) Query: 327 ITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNR---------- 376 S + V +TC +Y+ W + SP+ + + ++ Sbjct: 5 TQSPAIMSASPGEKVTMTCSASSSR-SYMQWYQQKP-GTSPKRWIYDTSKLASGVPARFS 62 Query: 377 --------TLTLLSVTRNDVGPYECGIQNKLSVDHSDPV-ILNVLYGPDDPTISPSYTYY 427 +LT+ S+ D Y C ++ + + I + P PS Sbjct: 63 GSGSGTSYSLTISSMEAEDAATYYCHQRSSYTFGGGTKLEIKRTVAAPSVFIFPPSDEQL 122 Query: 428 RPGVNLSLSCHAASNP-PAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGH 486 + G + P A+ W +D +Q + ++ K+S Y+ + + S Sbjct: 123 KSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTLSKA 181 Query: 487 SRTTVKTITVSAELPKPSISSNNSKPVEDKD 517 K + E+ +SS +K + Sbjct: 182 DYEKHK--VYACEVTHQGLSSPVTKSFNRGE 210 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 29/196 (14%), Positives = 54/196 (27%), Gaps = 40/196 (20%) Query: 240 PTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNG------TFQQSTQEL--------- 284 T SP S GE + ++C A+S+ W+ + T +L Sbjct: 4 STQSPAIMSASPGEKVTMTCSASSSRS-YMQWYQQKPGTSPKRWIYDTSKLASGVPARFS 62 Query: 285 ----------FIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 I ++ ++ +Y C S T I P FI + Sbjct: 63 GSGSGTSYSLTISSMEAEDAATYYCH-QRSSYTFGGGTKLEIKRTVAAPSVFIFPPSDEQ 121 Query: 335 VEDEDAVALTCEPEI--QNTTYLWWV----------NNQSLPVSPRLQLSNDNRTLTLLS 382 ++ ++ C + W + + + TLTL Sbjct: 122 LKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSK 180 Query: 383 VTRNDVGPYECGIQNK 398 Y C + ++ Sbjct: 181 ADYEKHKVYACEVTHQ 196 Score = 39.2 bits (89), Expect = 0.007, Method: Composition-based stats. Identities = 29/214 (13%), Positives = 69/214 (32%), Gaps = 27/214 (12%) Query: 147 PSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNR-------- 198 S S + V TC + + W+ Q SP+ + + ++ Sbjct: 3 VSTQSPAIMSASPGEKVTMTCSASSSRSYMQWYQ--QKPGTSPKRWIYDTSKLASGVPAR 60 Query: 199 ----------TLTLFNVTRNDTASYKCETQNPVSARRSDSVIL-NVLYGPDAPTISPLNT 247 +LT+ ++ D A+Y C ++ + + + + P P + Sbjct: 61 FSGSGSGTSYSLTISSMEAEDAATYYCHQRSSYTFGGGTKLEIKRTVAAPSVFIFPPSDE 120 Query: 248 SYRSGENLNLSCHAASNPP--AQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSD 305 +SG ++ C + P A+ W V+ Q + + +S +Y+ + + Sbjct: 121 QLKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTL 178 Query: 306 TGLNRTTVTTITVYAEPPKPFITSNNSNPVEDED 339 + + E ++S + + Sbjct: 179 SKADYEK--HKVYACEVTHQGLSSPVTKSFNRGE 210 Score = 38.4 bits (87), Expect = 0.012, Method: Composition-based stats. Identities = 30/204 (14%), Positives = 63/204 (30%), Gaps = 21/204 (10%) Query: 503 PSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNG----------------QSLPVSPR 546 S S + V TC + + W+ +P Sbjct: 3 VSTQSPAIMSASPGEKVTMTCSASSSRSYMQWYQQKPGTSPKRWIYDTSKLASGVPARFS 62 Query: 547 LQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYL 606 S + +LT+ ++ DA Y C ++S + + + + I PP L Sbjct: 63 GSGSGTSYSLTISSMEAEDAATYYCHQRSSYTFGGGTKLEIKRTVAAPSVFIFPPSDEQL 122 Query: 607 SGANLNLSCHSASNPS--PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGR 664 ++ C + + W+++ Q + + ++ TY+ + + Sbjct: 123 KSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTLSKA 181 Query: 665 NNSIVKSITVSASGTSPGLSAGAT 688 + K + T GLS+ T Sbjct: 182 DYEKHKVY--ACEVTHQGLSSPVT 203 Score = 36.8 bits (83), Expect = 0.030, Method: Composition-based stats. Identities = 31/196 (15%), Positives = 63/196 (32%), Gaps = 38/196 (19%) Query: 417 DPTISPSYTYYRPGVNLSLSCHAASN----------PPAQ-YSWLID------GNIQQH- 458 T SP+ PG ++++C A+S+ P W+ D G + Sbjct: 3 VSTQSPAIMSASPGEKVTMTCSASSSRSYMQWYQQKPGTSPKRWIYDTSKLASGVPARFS 62 Query: 459 ------TQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKP 512 + L IS++ +++ Y C S+ T I + P I + + Sbjct: 63 GSGSGTSYSLTISSMEAEDAATYYCHQR-SSYTFGGGTKLEIKRTVAAPSVFIFPPSDEQ 121 Query: 513 VEDKDAVAFTCEPEAQNT---TYLWWVNGQSLPVSPRLQLS---------NGNRTLTLFN 560 ++ + C W V+ + + ++ + + TLTL Sbjct: 122 LKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSK 180 Query: 561 VTRNDARAYVCGIQNS 576 + Y C + + Sbjct: 181 ADYEKHKVYACEVTHQ 196 Score = 36.8 bits (83), Expect = 0.035, Method: Composition-based stats. Identities = 29/177 (16%), Positives = 50/177 (28%), Gaps = 18/177 (10%) Query: 67 WYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIK 126 WY+ + G ++ A+ PA + SL I ++ D Y H Sbjct: 34 WYQ--QKPGTSPKRWIYDTSKLASGVPARFSGSGSGTSYSLTISSMEAEDAATYYCHQRS 91 Query: 127 SDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQD--ATYLWWVNN-- 182 S + + P I + + ++ A A W V+N Sbjct: 92 SYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNAL 151 Query: 183 -------QSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ-----NPVSARRSD 227 + + + TLTL Y CE +PV+ + Sbjct: 152 QSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR 208 >1N26-A nrPDB Length = 325 Score = 39.5 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 23/85 (27%), Positives = 38/85 (44%), Gaps = 5/85 (5%) Query: 160 KDAVAFTC-EPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ 218 D+V TC E +D + WV + S + + R L L +V +D+ +Y C Sbjct: 21 GDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSC--- 77 Query: 219 NPVSARRSDSVILNVLYGPDAPTIS 243 + R + +V L V P+ P +S Sbjct: 78 -YRAGRPAGTVHLLVDVPPEEPQLS 101 Score = 33.8 bits (75), Expect = 0.25, Method: Composition-based stats. Identities = 24/88 (27%), Positives = 34/88 (38%), Gaps = 11/88 (12%) Query: 516 KDAVAFTC---EPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVC- 571 D+V TC EPE T + WV + S + + R L L +V +D+ Y C Sbjct: 21 GDSVTLTCPGVEPEDNATVH--WVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCY 78 Query: 572 GIQNSVSANRSDPVTLDVLYGPDTPIIS 599 V L V P+ P +S Sbjct: 79 RAGRPAG-----TVHLLVDVPPEEPQLS 101 Score = 33.8 bits (75), Expect = 0.30, Method: Composition-based stats. Identities = 17/83 (20%), Positives = 30/83 (36%), Gaps = 14/83 (16%) Query: 429 PGVNLSLSCHAASNPP--AQYSWL--------IDGNIQQHTQELFISNITEKNSGLYTCQ 478 PG +++L+C P A W+ + L + ++ +SG Y+C Sbjct: 20 PGDSVTLTCPGV-EPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSC- 77 Query: 479 ANNSASGHSRTTVKTITVSAELP 501 A + T + V E P Sbjct: 78 --YRAGRPAGTVHLLVDVPPEEP 98 Score = 33.0 bits (73), Expect = 0.42, Method: Composition-based stats. Identities = 24/86 (27%), Positives = 37/86 (43%), Gaps = 5/86 (5%) Query: 337 DEDAVALTC-EPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGI 395 D+V LTC E ++ + WV + S + + R L L SV +D G Y C Sbjct: 20 PGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSC-- 77 Query: 396 QNKLSVDHSDPVILNVLYGPDDPTIS 421 + + V L V P++P +S Sbjct: 78 --YRAGRPAGTVHLLVDVPPEEPQLS 101 Score = 32.6 bits (72), Expect = 0.68, Method: Composition-based stats. Identities = 20/99 (20%), Positives = 37/99 (37%), Gaps = 20/99 (20%) Query: 251 SGENLNLSCHAASNPP--AQYSWFVN--------GTFQQSTQELFIPNITVNNSGSYTCQ 300 G+++ L+C P A W + + + L + ++ +++SG+Y+C Sbjct: 20 PGDSVTLTCPGV-EPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCY 78 Query: 301 AHNSDTGLNRTTVTTITVYAEPPKP----FITSNNSNPV 335 G + V P +P F S SN V Sbjct: 79 RAGRPAG-----TVHLLVDVPPEEPQLSCFRKSPLSNVV 112 >5X5W-B nrPDB Length = 107 Score = 39.2 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 14/48 (29%), Positives = 20/48 (41%), Gaps = 8/48 (16%) Query: 272 FVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVY 319 F +GT + S EL + G Y C+ G NR + +TV Sbjct: 68 FTDGTIRLSRLEL-------EDEGVYICEFATFPAG-NRESQLNLTVM 107 Score = 31.8 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 17/100 (17%), Positives = 33/100 (33%), Gaps = 8/100 (8%) Query: 403 HSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQH---- 458 V+L+ + P + + ++ N S A NP S L + Sbjct: 7 IGTDVVLHCSFANPLPGVKITQVTWQKATNGSKQNVAIYNPAMGVSVLAPYRERVEFLRP 66 Query: 459 ---TQELFISNITEKNSGLYTCQ-ANNSASGHSRTTVKTI 494 + +S + ++ G+Y C+ A A T+ Sbjct: 67 SFTDGTIRLSRLELEDEGVYICEFATFPAGNRESQLNLTV 106 >4L1D-A nrPDB Length = 127 Score = 39.2 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 22/89 (24%), Positives = 33/89 (37%), Gaps = 8/89 (8%) Query: 513 VEDKDAVAFTCEPEAQNTTYLW-WVNGQSLPVSP---RLQLSNG----NRTLTLFNVTRN 564 VE V + PE ++ + NG SP RLQ + + ++T+ NVT N Sbjct: 30 VEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLN 89 Query: 565 DARAYVCGIQNSVSANRSDPVTLDVLYGP 593 D+ Y C + P P Sbjct: 90 DSGLYTCNVSREFEFEAHRPFVKTTRLIP 118 Score = 37.2 bits (84), Expect = 0.022, Method: Composition-based stats. Identities = 25/112 (22%), Positives = 37/112 (33%), Gaps = 9/112 (8%) Query: 313 VTTITVYAEPPKPF-ITSNNSNPVEDEDAVALTCEPEIQNTTYLW-WVNNQSLPVSPRLQ 370 T V P K I+ VE V PE ++ + N SP Sbjct: 7 SETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQG 66 Query: 371 LSNDNRT-------LTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGP 415 N + +T+L+VT ND G Y C + + + P + P Sbjct: 67 RLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIP 118 Score = 34.1 bits (76), Expect = 0.19, Method: Composition-based stats. Identities = 14/82 (17%), Positives = 29/82 (35%), Gaps = 7/82 (8%) Query: 51 VLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREI-----IYPNA 105 + + + W+ R +G + + Y + GR + Sbjct: 22 ISCMKREEVEATTVVEWFY--RPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDV 79 Query: 106 SLLIQNIIQNDTGFYTLHVIKS 127 S+ + N+ ND+G YT +V + Sbjct: 80 SITVLNVTLNDSGLYTCNVSRE 101 Score = 33.0 bits (73), Expect = 0.50, Method: Composition-based stats. Identities = 11/39 (28%), Positives = 18/39 (46%), Gaps = 2/39 (5%) Query: 268 QYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDT 306 + W NG+ + + N+T+N+SG YTC Sbjct: 67 RLQW--NGSKDLQDVSITVLNVTLNDSGLYTCNVSREFE 103 >1ORQ-A nrPDB Length = 215 Score = 39.2 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 36/191 (18%), Positives = 65/191 (34%), Gaps = 42/191 (21%) Query: 160 KDAVAFTCEPETQ-DATYLWWVNNQS-----------------LPVSPRLQLSNGNRTLT 201 + V TC + ++YL W +S +P S + +LT Sbjct: 16 GEKVTMTCRARSSVSSSYLHWYQQKSGASPKLWIYSTSNLASGVPARFSGSGSGTSYSLT 75 Query: 202 LFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTSYRSGENLNLS 258 + +V DTA+Y C+ + L + APT+S P + SG ++ Sbjct: 76 ISSVEAEDTATYYCQQYSGNPWTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSG-GASVV 134 Query: 259 CHAASNPPAQY--SWFVNGTFQQS------------------TQELFIPNITVNNSGSYT 298 C + P W ++G+ +Q+ + L + SYT Sbjct: 135 CFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYT 194 Query: 299 CQAHNSDTGLN 309 C+A + + Sbjct: 195 CEATHKTSTSP 205 Score = 36.5 bits (82), Expect = 0.037, Method: Composition-based stats. Identities = 36/203 (17%), Positives = 58/203 (28%), Gaps = 46/203 (22%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQY-SWFVNGT------FQQSTQ----------- 282 T SP S GE + ++C A S+ + Y W+ + + ST Sbjct: 5 TQSPAIMSPSPGEKVTMTCRARSSVSSSYLHWYQQKSGASPKLWIYSTSNLASGVPARFS 64 Query: 283 --------ELFIPNITVNNSGSYTCQA-----HNSDTGLN---RTTVTTITVYAEPPKPF 326 L I ++ ++ +Y CQ G + TV PP Sbjct: 65 GSGSGTSYSLTISSVEAEDTATYYCQQYSGNPWTFGGGTKLEIKRADAAPTVSIFPPSSE 124 Query: 327 --------ITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTL 378 + +N + V + + L +Q S + TL Sbjct: 125 QLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSM----SSTL 180 Query: 379 TLLSVTRNDVGPYECGIQNKLSV 401 TL Y C +K S Sbjct: 181 TLTKDEYERHNSYTCEATHKTST 203 Score = 36.5 bits (82), Expect = 0.047, Method: Composition-based stats. Identities = 34/200 (17%), Positives = 62/200 (31%), Gaps = 42/200 (21%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQY-SWLID------------------GNIQQH- 458 T SP+ PG ++++C A S+ + Y W G + Sbjct: 5 TQSPAIMSPSPGEKVTMTCRARSSVSSSYLHWYQQKSGASPKLWIYSTSNLASGVPARFS 64 Query: 459 ------TQELFISNITEKNSGLYTCQANNSASGHS--RTTVKTITVSAELPKPSISSNNS 510 + L IS++ +++ Y CQ S + + T I + P SI +S Sbjct: 65 GSGSGTSYSLTISSVEAEDTATYYCQ-QYSGNPWTFGGGTKLEIKRADAAPTVSIFPPSS 123 Query: 511 KPVEDKDAVAFTCEPEAQNTT---YLWWVNGQSLPV---------SPRLQLSNGNRTLTL 558 + + + C W ++G + + + TLTL Sbjct: 124 EQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTL 182 Query: 559 FNVTRNDARAYVCGIQNSVS 578 +Y C + S Sbjct: 183 TKDEYERHNSYTCEATHKTS 202 Score = 31.4 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 29/199 (14%), Positives = 57/199 (28%), Gaps = 40/199 (20%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTT--YLWWVNGQS----------------LPVSPRL 547 S + V TC + ++ W+ +P Sbjct: 6 QSPAIMSPSPGEKVTMTCRARSSVSSSYLHWYQQKSGASPKLWIYSTSNLASGVPARFSG 65 Query: 548 QLSNGNRTLTLFNVTRNDARAYVCG--IQNSVSANRSDPVTLDVLYGPDTPIISPPDSSY 605 S + +LT+ +V D Y C N + + + T I PP S Sbjct: 66 SGSGTSYSLTISSVEAEDTATYYCQQYSGNPWTFGGGTKLEIKRADAAPTVSIFPPSSEQ 125 Query: 606 LSGANLNLSCHSASNPSPQYS--WRINGIPQQHT------------------QVLFIAKI 645 L+ ++ C + + W+I+G +Q+ L + K Sbjct: 126 LTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKD 185 Query: 646 TPNNNGTYACFVSNLATGR 664 + +Y C ++ + Sbjct: 186 EYERHNSYTCEATHKTSTS 204 >4LLY-B nrPDB Length = 212 Score = 39.2 bits (89), Expect = 0.007, Method: Composition-based stats. Identities = 29/195 (14%), Positives = 50/195 (25%), Gaps = 37/195 (18%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQYSWLID------------------GNIQQHTQ 460 T SPS G ++++C A+ + +W D G + + Sbjct: 5 TQSPSSLSASVGDRVTITCKASQDVSIGVAWYQDKPGKAPKLLIYSASYRYTGVPSRFSG 64 Query: 461 -------ELFISNITEKNSGLYTCQANNSASGHSRT-TVKTITVSAELPKPSISSNNSKP 512 L IS++ ++ Y CQ T I + S Sbjct: 65 SGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIKGQPKAAPSVTLFPPSSE 124 Query: 513 VEDKDAVAFTCEPEAQNT---TYLWWVNGQSLP--VSPRLQLSNGNRT------LTLFNV 561 + C T W + + V N L+L Sbjct: 125 ELQANKATLVCYISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAAWSYLSLTPE 184 Query: 562 TRNDARAYVCGIQNS 576 R+Y C + + Sbjct: 185 QWKSHRSYSCQVTHE 199 Score = 36.5 bits (82), Expect = 0.040, Method: Composition-based stats. Identities = 34/206 (16%), Positives = 65/206 (31%), Gaps = 39/206 (18%) Query: 149 ISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRL 191 S +S D V TC+ + + W ++ +P Sbjct: 5 TQSPSSLSASVGDRVTITCKASQDVSIGVAWYQDKPGKAPKLLIYSASYRYTGVPSRFSG 64 Query: 192 QLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAP---TISPLNTS 248 S + TLT+ ++ D A+Y C+ + + P A T+ P ++ Sbjct: 65 SGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIKGQPKAAPSVTLFPPSSE 124 Query: 249 YRSGENLNLSCHAASNPPA--QYSWFVNGTFQQSTQELFIPNITVNNS------------ 294 L C+ + P +W + + ++ E P+ NN Sbjct: 125 ELQANKATLVCYISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAAWSYLSLTPE 184 Query: 295 -----GSYTCQAHNSDTGLNRTTVTT 315 SY+CQ + + + +T T Sbjct: 185 QWKSHRSYSCQVTHEGSTVEKTVAPT 210 Score = 31.4 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 29/198 (14%), Positives = 62/198 (31%), Gaps = 37/198 (18%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP + S G+ + ++C A+ + +W+ + G Sbjct: 5 TQSPSSLSASVGDRVTITCKASQDVSIGVAWYQDKPGKAPKLLIYSASYRYTGVPSRFSG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQAHN-SDTGLNRTTVTTITVY-AEPPKPFITSNNSN 333 + + L I ++ + +Y CQ + + T I P + +S Sbjct: 65 SGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIKGQPKAAPSVTLFPPSSE 124 Query: 334 PVEDEDAVALTCEPEIQNTT-YLWWVNN------QSLPVSPRLQLSNDNRTLTLLSVTRN 386 ++ A + + + W + +P Q +N + LS+T Sbjct: 125 ELQANKATLVCYISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAAWSYLSLTPE 184 Query: 387 D---VGPYECGIQNKLSV 401 Y C + ++ S Sbjct: 185 QWKSHRSYSCQVTHEGST 202 Score = 30.3 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 34/207 (16%), Positives = 59/207 (28%), Gaps = 39/207 (18%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS---------------LPVSPRLQ 370 S +S D V +TC+ + + W ++ V R Sbjct: 4 MTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQDKPGKAPKLLIYSASYRYTGVPSRFS 63 Query: 371 LSNDNR--TLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDD---PTISPSYT 425 S TLT+ S+ D Y C + + P T+ P + Sbjct: 64 GSGSGTDFTLTISSLQPEDFATYYCQQYYIYPYTFGQGTKVEIKGQPKAAPSVTLFPPSS 123 Query: 426 YYRPGVNLSLSCHAAS-NPPA-QYSWLIDGNIQQHT-----------------QELFISN 466 +L C+ + P A +W D + + L ++ Sbjct: 124 EELQANKATLVCYISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAAWSYLSLTP 183 Query: 467 ITEKNSGLYTCQANNSASGHSRTTVKT 493 K+ Y+CQ + S +T T Sbjct: 184 EQWKSHRSYSCQVTHEGSTVEKTVAPT 210 >5B21-A nrPDB Length = 114 Score = 39.2 bits (89), Expect = 0.007, Method: Composition-based stats. Identities = 19/100 (19%), Positives = 37/100 (37%), Gaps = 10/100 (10%) Query: 229 VILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPP------AQYSWFVNGTFQQS-- 280 V+L+ + P++ +++ N + A NP Y + S Sbjct: 17 VVLHCSFANPLPSVKITQVTWQKASNGSKQNMAIYNPTMGVSVLPPYE-KRVEFLRPSFI 75 Query: 281 TQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYA 320 + + + + + G Y C+ TG NR + +TV A Sbjct: 76 DGTIRLSGLELEDEGMYICEFATFPTG-NRESQLNLTVMA 114 Score = 31.8 bits (70), Expect = 0.99, Method: Composition-based stats. Identities = 17/103 (16%), Positives = 31/103 (30%), Gaps = 8/103 (7%) Query: 45 VAEGKEVLLLVHN-LPQHLFG-YSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIY 102 + + N LP +W K +G++Q + T + P Y R Sbjct: 13 IGTDVVLHCSFANPLPSVKITQVTWQKAS--NGSKQNMAIYNPTMGVSVLPPYEKRVEFL 70 Query: 103 P----NASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVY 141 + ++ + + D G Y N E+ V Sbjct: 71 RPSFIDGTIRLSGLELEDEGMYICEFATFPTGNRESQLNLTVM 113 >1F6L-L nrPDB Length = 114 Score = 38.8 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 19/88 (21%), Positives = 32/88 (36%), Gaps = 25/88 (28%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP + S GE + ++C A+ N + +W+ G Sbjct: 5 TQSPASLSASVGETVTITCRASENIYSYLAWYQQKQGKSPQLLVYNAKTLAEGVPSRFSG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQAHN 303 + + L I ++ + GSY CQ H Sbjct: 65 SGSGTQFSLKINSLQPEDFGSYYCQHHY 92 Score = 32.2 bits (71), Expect = 0.70, Method: Composition-based stats. Identities = 15/83 (18%), Positives = 25/83 (30%), Gaps = 25/83 (30%) Query: 599 SPPDSSYLSGANLNLSCHSASNPSPQYSW-------------------------RINGIP 633 SP S G + ++C ++ N +W R +G Sbjct: 7 SPASLSASVGETVTITCRASENIYSYLAWYQQKQGKSPQLLVYNAKTLAEGVPSRFSGSG 66 Query: 634 QQHTQVLFIAKITPNNNGTYACF 656 L I + P + G+Y C Sbjct: 67 SGTQFSLKINSLQPEDFGSYYCQ 89 Score = 31.8 bits (70), Expect = 0.90, Method: Composition-based stats. Identities = 13/84 (15%), Positives = 23/84 (27%), Gaps = 17/84 (20%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTY-LWWVNG----------------QSLPVSPRLQ 548 S S + V TC +Y W+ + +P Sbjct: 6 QSPASLSASVGETVTITCRASENIYSYLAWYQQKQGKSPQLLVYNAKTLAEGVPSRFSGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCG 572 S +L + ++ D +Y C Sbjct: 66 GSGTQFSLKINSLQPEDFGSYYCQ 89 >1HZH-L nrPDB Length = 215 Score = 38.8 bits (88), Expect = 0.009, Method: Composition-based stats. Identities = 26/161 (16%), Positives = 46/161 (28%), Gaps = 12/161 (7%) Query: 428 RPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHS 487 +PG L H SN + S G+ L I+ + ++ LY CQ ++S Sbjct: 40 KPGQAPRLVIHGVSNRASGISDRFSGSGSGTDFTLTITRVEPEDFALYYCQVYGASSYTF 99 Query: 488 RTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNT---TYLWWVNGQSLPVS 544 K S + C W V+ + Sbjct: 100 GQGTKLERKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN 159 Query: 545 PRLQLS---------NGNRTLTLFNVTRNDARAYVCGIQNS 576 + ++ + + TLTL + Y C + + Sbjct: 160 SQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQ 200 Score = 38.4 bits (87), Expect = 0.012, Method: Composition-based stats. Identities = 31/178 (17%), Positives = 59/178 (33%), Gaps = 11/178 (6%) Query: 169 PETQDATYLWWVNNQSLPVSPRLQLSNGNR--TLTLFNVTRNDTASYKCETQNPVSARRS 226 P + V+N++ +S R S TLT+ V D A Y C+ S Sbjct: 41 PGQAPRLVIHGVSNRASGISDRFSGSGSGTDFTLTITRVEPEDFALYYCQVYGASSYTFG 100 Query: 227 DSVILNVLYGPDAPTIS---PLNTSYRSGENLNLSCHAASNPP--AQYSWFVNGTFQQST 281 L AP++ P + +SG ++ C + P A+ W V+ Q Sbjct: 101 QGTKLERKRTVAAPSVFIFPPSDEQLKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGN 159 Query: 282 QELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDED 339 + + +S +Y+ + + + + E + S + + Sbjct: 160 SQESVTEQDSKDS-TYSLSSTLTLSKADYEK--HKVYACEVTHQGLRSPVTKSFNRGE 214 Score = 36.1 bits (81), Expect = 0.057, Method: Composition-based stats. Identities = 28/180 (15%), Positives = 55/180 (30%), Gaps = 20/180 (11%) Query: 66 SWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHV- 124 +WY+ + R +I + + + + +SG + +L I + D Y V Sbjct: 35 AWYQHKPGQAPRLVI-HGVSNRASGISDRFSGSGSGT-DFTLTITRVEPEDFALYYCQVY 92 Query: 125 -IKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQD--ATYLWWVN 181 S + + + P I + + ++ A A W V+ Sbjct: 93 GASSYTFGQGTKLERKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVD 152 Query: 182 N---------QSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCET-----QNPVSARRSD 227 N + + + TLTL Y CE ++PV+ + Sbjct: 153 NALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVTKSFNR 212 Score = 31.8 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 21/124 (16%), Positives = 42/124 (33%), Gaps = 7/124 (5%) Query: 550 SNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLD---VLYGPDTPIISPPDSSYL 606 S + TLT+ V D Y C + + S L+ + P I P D Sbjct: 68 SGTDFTLTITRVEPEDFALYYCQVYGASSYTFGQGTKLERKRTVAAPSVFIFPPSDEQLK 127 Query: 607 SGANLNLSCHSASNPS--PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGR 664 SG ++ C + + W+++ Q + + ++ TY+ + + Sbjct: 128 SG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSSTLTLSKA 185 Query: 665 NNSI 668 + Sbjct: 186 DYEK 189 >1OSP-L nrPDB Length = 214 Score = 38.4 bits (87), Expect = 0.011, Method: Composition-based stats. Identities = 36/192 (18%), Positives = 60/192 (31%), Gaps = 45/192 (23%) Query: 338 EDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTR---NDVG-PYEC 393 D V +TC+ + L W + +PRL +S +L +R +D G Y Sbjct: 16 GDRVTITCKASEDIYSRLAWYQQKP-GNAPRLLISGAT-SLETWVPSRFSGSDSGKDYTL 73 Query: 394 GIQNKLSVDHSDPV------------------ILNVLYGPDDPTISPSYTYYRPGVNLSL 435 I + + D + I P PS G S+ Sbjct: 74 SITSLQTEDVATYFCQQYWSPPPTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSG-GASV 132 Query: 436 SCHAASNPPAQYS--WLIDGNIQQH------------------TQELFISNITEKNSGLY 475 C + P + W IDG+ +Q+ + L ++ + Y Sbjct: 133 VCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSY 192 Query: 476 TCQANNSASGHS 487 TC+A + S Sbjct: 193 TCEATHKTSTSP 204 Score = 31.1 bits (68), Expect = 2.0, Method: Composition-based stats. Identities = 33/190 (17%), Positives = 60/190 (31%), Gaps = 41/190 (21%) Query: 160 KDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRLQLSNGNRTLTL 202 D V TC+ + L W + +P S + TL++ Sbjct: 16 GDRVTITCKASEDIYSRLAWYQQKPGNAPRLLISGATSLETWVPSRFSGSDSGKDYTLSI 75 Query: 203 FNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTSYRSGENLNLSC 259 ++ D A+Y C+ L + APT+S P + SG ++ C Sbjct: 76 TSLQTEDVATYFCQQYWSPPPTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSG-GASVVC 134 Query: 260 HAASNPPAQY--SWFVNGTFQQS------------------TQELFIPNITVNNSGSYTC 299 + P W ++G+ +Q+ + L + SYTC Sbjct: 135 FLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTC 194 Query: 300 QAHNSDTGLN 309 +A + + Sbjct: 195 EATHKTSTSP 204 Score = 30.7 bits (67), Expect = 2.4, Method: Composition-based stats. Identities = 20/142 (14%), Positives = 36/142 (25%), Gaps = 12/142 (8%) Query: 272 FVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTIT--VYAEPPKPFITS 329 +G+ L I ++ + +Y CQ + S A P Sbjct: 61 RFSGSDSGKDYTLSITSLQTEDVATYFCQQYWSPPPTFGGGTKLEIKRADAAPTVSIFPP 120 Query: 330 NNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS----------LPVSPRLQLSNDNRTLT 379 ++ +V + W + S + + + TLT Sbjct: 121 SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLT 180 Query: 380 LLSVTRNDVGPYECGIQNKLSV 401 L Y C +K S Sbjct: 181 LTKDEYERHNSYTCEATHKTST 202 Score = 29.1 bits (63), Expect = 7.1, Method: Composition-based stats. Identities = 28/171 (16%), Positives = 52/171 (30%), Gaps = 15/171 (8%) Query: 66 SWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVI 125 +WY+ + + R +I + P +SG + + +L I ++ D Y Sbjct: 34 AWYQQKPGNAPRLLISGATSLETWVPS-RFSGSDSGK-DYTLSITSLQTEDVATYFCQQY 91 Query: 126 KSDLVNEEATGQFRVYPELPKPSIS----SNNSKPVEDKDAVAFTCEPETQDATYLWWVN 181 S + + P++S S+ V F +D W ++ Sbjct: 92 WSPPPTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKID 151 Query: 182 NQS---------LPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSA 223 + + + TLTL SY CE + S Sbjct: 152 GSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTST 202 >6DE7-L nrPDB Length = 213 Score = 38.4 bits (87), Expect = 0.011, Method: Composition-based stats. Identities = 34/179 (18%), Positives = 58/179 (32%), Gaps = 31/179 (17%) Query: 168 EPETQDATYLWWVNNQSLPVSPRLQ------LSNGNRTLTLFNVTRNDTASYKCET---Q 218 + Q + + + NN P TLT+ +V D A Y C + Sbjct: 32 QRPGQAPSLIIYNNNDRPSGIPDRFSGSPGSTFGTTATLTITSVEAGDEADYYCHIWDSR 91 Query: 219 NPVSARRSDSVILNVLYGPDAP---TISPLNTSYRSGENLNLSCHAASNPPA--QYSWFV 273 P + + L VL P A T+ P ++ L C + P +W Sbjct: 92 RPTNWVFGEGTTLIVLSQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKA 151 Query: 274 NGTFQQSTQELFIPNITVNNS-----------------GSYTCQAHNSDTGLNRTTVTT 315 + + ++ E P+ NN SY+CQ + + + +T T Sbjct: 152 DSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPT 210 Score = 32.6 bits (72), Expect = 0.57, Method: Composition-based stats. Identities = 29/191 (15%), Positives = 53/191 (27%), Gaps = 21/191 (10%) Query: 46 AEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYP-- 103 + + +L WY+ +R +I Y + + +SG Sbjct: 10 GQTARITCGEESLGSRSVI--WYQ-QRPGQAPSLIIYNNNDRPSGIPDRFSGSPGSTFGT 66 Query: 104 NASLLIQNIIQNDTGFYTLHVIKSDLVNE----EATGQFRVYPELPKPSIS----SNNSK 155 A+L I ++ D Y H+ S E T + PS++ S+ Sbjct: 67 TATLTITSVEAGDEADYYCHIWDSRRPTNWVFGEGTTLIVLSQPKAAPSVTLFPPSSEEL 126 Query: 156 PVEDKDAVAFTCEPETQDATYLWWVNNQSL--------PVSPRLQLSNGNRTLTLFNVTR 207 V + T W ++ + P + L+L Sbjct: 127 QANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQW 186 Query: 208 NDTASYKCETQ 218 SY C+ Sbjct: 187 KSHKSYSCQVT 197 Score = 31.8 bits (70), Expect = 0.96, Method: Composition-based stats. Identities = 37/188 (19%), Positives = 59/188 (31%), Gaps = 20/188 (10%) Query: 515 DKDAVAFTCEPEAQNTTYLWWVNGQSLP-VSPRLQLSNGNR-----TLTLFNVTRNDARA 568 +V + + Q + + + N + R S G+ TLT+ +V D Sbjct: 23 GSRSVIWYQQRPGQAPSLIIYNNNDRPSGIPDRFSGSPGSTFGTTATLTITSVEAGDEAD 82 Query: 569 YVCGIQNSVSAN---RSDPVTLDVLYGP---DTPIISPPDSSYLSGANLNLSCHSASNPS 622 Y C I +S + TL VL P + + PP S L L C + Sbjct: 83 YYCHIWDSRRPTNWVFGEGTTLIVLSQPKAAPSVTLFPPSSEELQANKATLVCLISDFYP 142 Query: 623 --PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKS----ITVSA 676 +W+ + P + NN YA T KS +T Sbjct: 143 GAVTVAWKADSSPVKAGVETTTPSKQSNNK--YAASSYLSLTPEQWKSHKSYSCQVTHEG 200 Query: 677 SGTSPGLS 684 S ++ Sbjct: 201 STVEKTVA 208 Score = 31.1 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 35/209 (16%), Positives = 62/209 (29%), Gaps = 45/209 (21%) Query: 330 NNSNPVEDEDAVALTCEPEIQNTTYLWWV---------------NNQSLPVSPRLQLSND 374 V +TC E + + W N++ + R S Sbjct: 2 PTFVSVAPGQTARITCGEESLGSRSVIWYQQRPGQAPSLIIYNNNDRPSGIPDRFSGSPG 61 Query: 375 -----NRTLTLLSVTRNDVGPYECGI------QNKLSVDHSDPVILNVLYGPDDPTISPS 423 TLT+ SV D Y C I N + + + ++L+ T+ P Sbjct: 62 STFGTTATLTITSVEAGDEADYYCHIWDSRRPTNWVFGEGTTLIVLSQPKAAPSVTLFPP 121 Query: 424 YTYYRPGVNLSLSCHAAS-NPPA-QYSWLIDGNIQQ-----------------HTQELFI 464 + +L C + P A +W D + + + L + Sbjct: 122 SSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSL 181 Query: 465 SNITEKNSGLYTCQANNSASGHSRTTVKT 493 + K+ Y+CQ + S +T T Sbjct: 182 TPEQWKSHKSYSCQVTHEGSTVEKTVAPT 210 >2BNU-B nrPDB Length = 241 Score = 38.4 bits (87), Expect = 0.012, Method: Composition-based stats. Identities = 20/159 (12%), Positives = 45/159 (28%), Gaps = 31/159 (19%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTYLWWV-------------------NGQSLPVSPR 546 + + ++ ++ C + + W+ + +P Sbjct: 4 QTPKFQVLKTGQSMTLQCAQDMNHEYMSWYRQDPGMGLRLIHYSVGAGITDQGEVPNGYN 63 Query: 547 LQLSN-GNRTLTLFNVTRNDARAYVCG---IQNSVSANRSDPVTLDVL------YGPDTP 596 + S + L L + + Y C + N+ + L VL + P+ Sbjct: 64 VSRSTTEDFPLRLLSAAPSQTSVYFCASSYVGNTGELFFGEGSRLTVLEDLKNVFPPEVA 123 Query: 597 IISPPDSSYLSGANLNLSCHSASNPSPQY--SWRINGIP 633 + P ++ L C + SW +NG Sbjct: 124 VFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKE 162 >1T7V-A nrPDB Length = 278 Score = 38.0 bits (86), Expect = 0.014, Method: Composition-based stats. Identities = 27/197 (13%), Positives = 53/197 (26%), Gaps = 27/197 (13%) Query: 139 RVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS--LPVSPRLQLSN- 195 ++ E K + F CE E ++ +W + ++ Sbjct: 75 DIFMETLKDIVEYYKDSTGSHVLQGRFGCEIENNRSSGAFWKYYYDGKDYIEFNKEIPAW 134 Query: 196 --GNRTLTLFNVTRNDTASYKCET------QNPVSARRSDSVILNVLYGPDAPTISPLNT 247 + + Y + P + R+ N+L D P++ + Sbjct: 135 VPFDPAAQITKQKWEAEPVYVQRAKAYLEEECPATLRKYLKYSKNILDRQDPPSVVVTSH 194 Query: 248 SYRSGENLNLSCHAASNPPAQY--SWFVNGTFQ-------------QSTQELFIPNITVN 292 GE L C A P + W G Q + Q + + Sbjct: 195 QA-PGEKKKLKCLAYDFYPGKIDVHWTRAGEVQEPELRGDVLHNGNGTYQSWVVVAVPPQ 253 Query: 293 NSGSYTCQAHNSDTGLN 309 ++ Y+C +S Sbjct: 254 DTAPYSCHVQHSSLAQP 270 >4EOW-L nrPDB Length = 216 Score = 37.6 bits (85), Expect = 0.016, Method: Composition-based stats. Identities = 33/173 (19%), Positives = 57/173 (32%), Gaps = 27/173 (15%) Query: 170 ETQDATYLWWVNNQSLPVSPRLQL---SNGNRTLTLFNVTRNDTASYKCETQNPVSARRS 226 L + NN+ P S+ + +L + + D A Y C T + + R Sbjct: 41 PGTAPKLLIYRNNRRPSGVPDRFSGSKSDTSASLAISGLRSEDEADYYCATWDDSLSGRL 100 Query: 227 DSV--ILNVLYGPDAP---TISPLNTSYRSGENLNLSCHAASNPPA--QYSWFVNGTFQQ 279 L VL P A T+ P ++ L C + P +W + + + Sbjct: 101 FGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVK 160 Query: 280 STQELFIPNITVNNS-----------------GSYTCQAHNSDTGLNRTTVTT 315 + E P+ NN SY+CQ + + + +T T Sbjct: 161 AGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT 213 >6J8I-C nrPDB Length = 215 Score = 37.6 bits (85), Expect = 0.018, Method: Composition-based stats. Identities = 12/63 (19%), Positives = 22/63 (34%), Gaps = 1/63 (1%) Query: 193 LSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSG 252 S + ++ L NV D Y C NP R +++ + P + G Sbjct: 105 PSKYDVSVMLRNVQPEDEGIYNCYIMNPPDRHRG-HGKIHLQVLMEEPPERDSTVAVIVG 163 Query: 253 ENL 255 ++ Sbjct: 164 ASV 166 Score = 35.3 bits (79), Expect = 0.10, Method: Composition-based stats. Identities = 13/71 (18%), Positives = 26/71 (36%), Gaps = 3/71 (4%) Query: 450 LIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNN 509 GN ++ + + N+ ++ G+Y C N H + V E P ++ Sbjct: 100 EFSGNPSKYDVSVMLRNVQPEDEGIYNCYIMNPPDRHRGHGKIHLQVLMEEPP---ERDS 156 Query: 510 SKPVEDKDAVA 520 + V +V Sbjct: 157 TVAVIVGASVG 167 Score = 34.1 bits (76), Expect = 0.21, Method: Composition-based stats. Identities = 9/63 (14%), Positives = 17/63 (26%) Query: 275 GTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP 334 G + + + N+ + G Y C N + V E P ++ Sbjct: 103 GNPSKYDVSVMLRNVQPEDEGIYNCYIMNPPDRHRGHGKIHLQVLMEEPPERDSTVAVIV 162 Query: 335 VED 337 Sbjct: 163 GAS 165 Score = 33.8 bits (75), Expect = 0.29, Method: Composition-based stats. Identities = 13/70 (18%), Positives = 27/70 (38%), Gaps = 3/70 (4%) Query: 629 INGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSAGAT 688 +G P ++ + + + P + G Y C++ N + V +T Sbjct: 101 FSGNPSKYDVSVMLRNVQPEDEGIYNCYIMNPPDRHRGHGKIHLQVLMEEPP---ERDST 157 Query: 689 VGIMIGVLVG 698 V +++G VG Sbjct: 158 VAVIVGASVG 167 >4NHU-B nrPDB Length = 254 Score = 37.6 bits (85), Expect = 0.020, Method: Composition-based stats. Identities = 24/156 (15%), Positives = 40/156 (25%), Gaps = 28/156 (17%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNG-------------------QSLPVSPR 546 S +K V +C + W+ +P + Sbjct: 10 QSPRNKVAVTGGKVTLSCNQTNNHNNMYWYRQDTGHGLRLIHYSYGAGSTEKGDIPDGYK 69 Query: 547 LQL-SNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVL------YGPDTPIIS 599 S N +L L T + Y C + L VL + P+ + Sbjct: 70 ASRPSQENFSLILELATPSQTSVYFCASGGGGTLYFGAGTRLSVLEDLKNVFPPEVAVFE 129 Query: 600 PPDSSYLSGANLNLSCHSASNPSPQY--SWRINGIP 633 P ++ L C + SW +NG Sbjct: 130 PSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKE 165 >2ADF-H nrPDB Length = 218 Score = 37.6 bits (85), Expect = 0.020, Method: Composition-based stats. Identities = 19/86 (22%), Positives = 27/86 (31%), Gaps = 9/86 (10%) Query: 194 SNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRS-- 251 S L + N+ DTA+Y C NP A + A T +P Sbjct: 75 SVSTAYLQINNLKNEDTATYFCARDNPYYA-LDYWGQGTTVTVSSAKTTAPSVYPLAPVC 133 Query: 252 ----GENLNLSCHAASN-PPA-QYSW 271 G ++ L C P +W Sbjct: 134 GDTTGSSVTLGCLVKGYFPEPVTLTW 159 Score = 33.0 bits (73), Expect = 0.44, Method: Composition-based stats. Identities = 18/83 (21%), Positives = 27/83 (32%), Gaps = 5/83 (6%) Query: 46 AEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGR-----EI 100 E ++ +G +W K G + + T + T G + GR E Sbjct: 15 GETVKISCKASGYTFINYGMNWVKQAPGKGLKWMGWKNTNTGETTYGEEFRGRFAFSLET 74 Query: 101 IYPNASLLIQNIIQNDTGFYTLH 123 A L I N+ DT Y Sbjct: 75 SVSTAYLQINNLKNEDTATYFCA 97 >1HCF-X nrPDB Length = 101 Score = 37.6 bits (85), Expect = 0.021, Method: Composition-based stats. Identities = 15/72 (20%), Positives = 20/72 (27%), Gaps = 16/72 (22%) Query: 260 HAASNPPAQYSWFVNGTFQQSTQ----------------ELFIPNITVNNSGSYTCQAHN 303 NP WF NG ++ L + N T N+G YT A N Sbjct: 24 TVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 83 Query: 304 SDTGLNRTTVTT 315 + Sbjct: 84 EYGKDEKQISAH 95 Score = 33.4 bits (74), Expect = 0.33, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 19/68 (27%), Gaps = 16/68 (23%) Query: 438 HAASNPPAQYSWLIDGNI---------QQHTQELF-------ISNITEKNSGLYTCQANN 481 NP W +G I + H + N T N+G YT A N Sbjct: 24 TVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 83 Query: 482 SASGHSRT 489 + Sbjct: 84 EYGKDEKQ 91 Score = 32.2 bits (71), Expect = 0.83, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 17/69 (24%), Gaps = 16/69 (23%) Query: 616 HSASNPSPQYSWRINGIPQQHTQV----------------LFIAKITPNNNGTYACFVSN 659 NP P W NG ++ L + T NNG Y N Sbjct: 24 TVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 83 Query: 660 LATGRNNSI 668 I Sbjct: 84 EYGKDEKQI 92 >1AQK-L nrPDB Length = 216 Score = 37.2 bits (84), Expect = 0.021, Method: Composition-based stats. Identities = 29/143 (20%), Positives = 49/143 (34%), Gaps = 23/143 (16%) Query: 194 SNGNRTLTLFNVTRNDTASYKC-ETQNPVSARRSDSVILNVLYGPDAP---TISPLNTSY 249 S + +L + + D A Y C + +SAR L VL P A T+ P ++ Sbjct: 69 SGTSASLAITGLQAEDEADYYCQSYDSSLSARFGGGTRLTVLGQPKAAPSVTLFPPSSEE 128 Query: 250 RSGENLNLSCHAASNPPA--QYSWFVNGTFQQSTQELFIPNITVNNS------------- 294 L C + P +W + + + E P+ NN Sbjct: 129 LQANKATLVCLISDFYPGAVTVAWKADSSPVNAGVETTKPSKQSNNKYAASSYLSLTPEQ 188 Query: 295 ----GSYTCQAHNSDTGLNRTTV 313 SY+CQ + + + +T Sbjct: 189 WKSHKSYSCQVTHEGSTVEKTVA 211 Score = 35.7 bits (80), Expect = 0.079, Method: Composition-based stats. Identities = 22/119 (18%), Positives = 42/119 (35%), Gaps = 3/119 (2%) Query: 251 SGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNR 310 G L A +N P+ +G+ ++ L I + + Y CQ+++S Sbjct: 42 PGTAPKLLIFANTNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSARF 101 Query: 311 TTVTTITVYAEP---PKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVS 366 T +TV +P P + +S ++ A + + S PV+ Sbjct: 102 GGGTRLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVN 160 >4NM4-L nrPDB Length = 220 Score = 37.2 bits (84), Expect = 0.025, Method: Composition-based stats. Identities = 30/210 (14%), Positives = 60/210 (28%), Gaps = 30/210 (14%) Query: 506 SSNNSKPVEDKDAVAFTCEP--------------------EAQNTTYLWW---VNGQSLP 542 S +S V + C+ Q L + +P Sbjct: 6 QSPDSLAVSLGERATINCKSSQSVFSSSTNKNYLAWYQQKPGQPPKVLIYWSSTRESGVP 65 Query: 543 VSPRLQLSNGNRTLTLFNVTRNDARAYVCG--IQNSVSANRSDPVTLDVLYGPDTPIISP 600 S + TLT+ ++ D Y C + + V + + I P Sbjct: 66 DRFSASGSGTDFTLTISSLQAADVAVYYCHQYYTAPWTFGQGTKVEIKRTVAAPSVFIFP 125 Query: 601 PDSSYLSGANLNLSCHSASNPS--PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVS 658 P L ++ C + + W+++ Q + + ++ TY+ + Sbjct: 126 PSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLSST 184 Query: 659 NLATGRNNSIVKSITVSASGTSPGLSAGAT 688 + + K + T GLS+ T Sbjct: 185 LTLSKADYEKHKVY--ACEVTHQGLSSPVT 212 Score = 36.8 bits (83), Expect = 0.036, Method: Composition-based stats. Identities = 26/178 (14%), Positives = 59/178 (33%), Gaps = 12/178 (6%) Query: 170 ETQDATYLWWVNNQSLPVSPRLQLSNGNRT---LTLFNVTRNDTASYKCETQNPVSARRS 226 Q L + ++ P ++G+ T LT+ ++ D A Y C Sbjct: 46 PGQPPKVLIYWSSTRESGVPDRFSASGSGTDFTLTISSLQAADVAVYYCHQYYTAPWTFG 105 Query: 227 DSVILNVLYGPDAPTIS---PLNTSYRSGENLNLSCHAASNPP--AQYSWFVNGTFQQST 281 + + AP++ P + +SG ++ C + P A+ W V+ Q Sbjct: 106 QGTKVEIKRTVAAPSVFIFPPSDEQLKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGN 164 Query: 282 QELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDED 339 + + +S +Y+ + + + + E ++S + + Sbjct: 165 SQESVTEQDSKDS-TYSLSSTLTLSKADYEK--HKVYACEVTHQGLSSPVTKSFNRGE 219 >3MCG-1 nrPDB Length = 216 Score = 37.2 bits (84), Expect = 0.026, Method: Composition-based stats. Identities = 31/171 (18%), Positives = 57/171 (33%), Gaps = 26/171 (15%) Query: 171 TQDATYLWWVNNQSLPVSPRLQL---SNGNRTLTLFNVTRNDTASYKCET-QNPVSARRS 226 + + + N+ P S +LT+ + D A Y C + + + Sbjct: 43 GKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNFVFG 102 Query: 227 DSVILNVLYGPDA-PTI--SPLNTSYRSGENLNLSCHAASNPPA--QYSWFVNGTFQQST 281 + VL P A PT+ P ++ L C + P +W +G+ ++ Sbjct: 103 TGTKVTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAG 162 Query: 282 QELFIPNITVNNS-----------------GSYTCQAHNSDTGLNRTTVTT 315 E P+ NN SY+CQ + + + +T T Sbjct: 163 VETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT 213 Score = 32.2 bits (71), Expect = 0.79, Method: Composition-based stats. Identities = 24/152 (15%), Positives = 48/152 (31%), Gaps = 32/152 (21%) Query: 243 SPLNTSYRSGENLNLSCHAASNPPAQY---SWFVN------------------------- 274 P + S G+++ +SC S+ Y SW+ Sbjct: 6 QPPSASGSLGQSVTISCTGTSSDVGGYNYVSWYQQHAGKAPKVIIYEVNKRPSGVPDRFS 65 Query: 275 GTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEP---PKPFITSNN 331 G+ +T L + + + Y C ++ T T +TV +P P + + Sbjct: 66 GSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNFVFGTGTKVTVLGQPKANPTVTLFPPS 125 Query: 332 SNPVEDEDAVALTCEPEIQNTT-YLWWVNNQS 362 S ++ A + + + W + S Sbjct: 126 SEELQANKATLVCLISDFYPGAVTVAWKADGS 157 >5XCS-B nrPDB Length = 166 Score = 36.8 bits (83), Expect = 0.033, Method: Composition-based stats. Identities = 21/117 (17%), Positives = 33/117 (28%), Gaps = 23/117 (19%) Query: 506 SSNNSKPVEDKDAVAFTCEP--------------------EAQNTTYLWW---VNGQSLP 542 S +S V + V +C+ Q L + +P Sbjct: 7 QSPSSLTVTAGEKVTMSCKSSQSLLNSGNQKNYLTWYQQKPGQPPKLLIYWASTRESGVP 66 Query: 543 VSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIIS 599 S + TLT+ +V D Y C NS L++ G D + Sbjct: 67 DRFTGSGSGRDFTLTISSVQAEDLAVYYCQNDNSHPLTFGAGTKLELKAGSDYEFLK 123 Score = 34.9 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 20/97 (20%), Positives = 31/97 (31%), Gaps = 23/97 (23%) Query: 325 PFITSNNSNPVEDEDAVALTCE---------------------PEIQNTTYLWWVNNQSL 363 S +S V + V ++C+ P ++W + + Sbjct: 4 ELTQSPSSLTVTAGEKVTMSCKSSQSLLNSGNQKNYLTWYQQKPGQPPKLLIYWASTRES 63 Query: 364 PVSPRLQLSNDNR--TLTLLSVTRNDVGPYECGIQNK 398 V R S R TLT+ SV D+ Y C N Sbjct: 64 GVPDRFTGSGSGRDFTLTISSVQAEDLAVYYCQNDNS 100 Score = 34.1 bits (76), Expect = 0.23, Method: Composition-based stats. Identities = 17/96 (17%), Positives = 30/96 (31%), Gaps = 31/96 (32%) Query: 241 TISPLNTSYRSGENLNLSCHA------ASNPPAQYSWFVN-------------------- 274 T SP + + +GE + +SC + + N +W+ Sbjct: 6 TQSPSSLTVTAGEKVTMSCKSSQSLLNSGNQKNYLTWYQQKPGQPPKLLIYWASTRESGV 65 Query: 275 -----GTFQQSTQELFIPNITVNNSGSYTCQAHNSD 305 G+ L I ++ + Y CQ NS Sbjct: 66 PDRFTGSGSGRDFTLTISSVQAEDLAVYYCQNDNSH 101 Score = 29.9 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 17/96 (17%), Positives = 34/96 (35%), Gaps = 4/96 (4%) Query: 128 DLVNEEATGQFRVYPELPKPSISSNNSK-PVEDKDAVAFTCEPETQDATYLWWVNNQSLP 186 +L ++ ++ SS + K+ + + + Q L + + Sbjct: 4 ELTQSPSSLTVTAGEKVTMSCKSSQSLLNSGNQKNYLTWYQQKPGQPPKLLIYWASTRES 63 Query: 187 VSPRLQLSNGNR---TLTLFNVTRNDTASYKCETQN 219 P +G+ TLT+ +V D A Y C+ N Sbjct: 64 GVPDRFTGSGSGRDFTLTISSVQAEDLAVYYCQNDN 99 >4AIZ-B nrPDB Length = 108 Score = 36.5 bits (82), Expect = 0.039, Method: Composition-based stats. Identities = 17/88 (19%), Positives = 23/88 (26%), Gaps = 17/88 (19%) Query: 508 NNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQS-----------------LPVSPRLQLS 550 S V TC +A Y +W + +P S Sbjct: 7 PPSVSVSPGQTARITCSGDALPKQYAYWYQQKPGQAPVLVIYKDSERPSGIPERFSGSSS 66 Query: 551 NGNRTLTLFNVTRNDARAYVCGIQNSVS 578 TLT+ V D Y C +S Sbjct: 67 GTTVTLTISGVQAEDEADYYCQSADSSG 94 Score = 34.1 bits (76), Expect = 0.20, Method: Composition-based stats. Identities = 15/92 (16%), Positives = 30/92 (32%), Gaps = 25/92 (27%) Query: 597 IISPPDSSYLSGANLNLSCHSASNPSPQYSW------------------RINGIPQQHTQ 638 ++ PP S G ++C + P W R +GIP++ + Sbjct: 4 LMQPPSVSVSPGQTARITCSGDALPKQYAYWYQQKPGQAPVLVIYKDSERPSGIPERFSG 63 Query: 639 -------VLFIAKITPNNNGTYACFVSNLATG 663 L I+ + + Y C ++ + Sbjct: 64 SSSGTTVTLTISGVQAEDEADYYCQSADSSGT 95 Score = 33.8 bits (75), Expect = 0.26, Method: Composition-based stats. Identities = 12/91 (13%), Positives = 28/91 (30%), Gaps = 4/91 (4%) Query: 40 STPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGRE 99 S + + + LP+ Y+++ ++ ++ Y + + +SG Sbjct: 9 SVSVSPGQTARITCSGDALPKQ---YAYWYQQKPGQAPVLVIYKDSERPSGIPERFSGSS 65 Query: 100 IIYPNASLLIQNIIQNDTGFYTLHVIKSDLV 130 +L I + D Y S Sbjct: 66 SGT-TVTLTISGVQAEDEADYYCQSADSSGT 95 Score = 33.8 bits (75), Expect = 0.29, Method: Composition-based stats. Identities = 15/81 (18%), Positives = 23/81 (28%), Gaps = 17/81 (20%) Query: 330 NNSNPVEDEDAVALTCEPEIQNTTYLWWV---------------NNQSLPVSPRLQLSND 374 S V +TC + Y +W + + + R S+ Sbjct: 7 PPSVSVSPGQTARITCSGDALPKQYAYWYQQKPGQAPVLVIYKDSERPSGIPERFSGSSS 66 Query: 375 NR--TLTLLSVTRNDVGPYEC 393 TLT+ V D Y C Sbjct: 67 GTTVTLTISGVQAEDEADYYC 87 Score = 33.4 bits (74), Expect = 0.31, Method: Composition-based stats. Identities = 14/90 (15%), Positives = 26/90 (28%), Gaps = 25/90 (27%) Query: 243 SPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------GTF 277 P + S G+ ++C + P W+ G+ Sbjct: 6 QPPSVSVSPGQTARITCSGDALPKQYAYWYQQKPGQAPVLVIYKDSERPSGIPERFSGSS 65 Query: 278 QQSTQELFIPNITVNNSGSYTCQAHNSDTG 307 +T L I + + Y CQ+ +S Sbjct: 66 SGTTVTLTISGVQAEDEADYYCQSADSSGT 95 Score = 33.4 bits (74), Expect = 0.33, Method: Composition-based stats. Identities = 16/79 (20%), Positives = 21/79 (26%), Gaps = 17/79 (21%) Query: 154 SKPVEDKDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRLQLSNG 196 S V TC + Y +W + +P S Sbjct: 9 SVSVSPGQTARITCSGDALPKQYAYWYQQKPGQAPVLVIYKDSERPSGIPERFSGSSSGT 68 Query: 197 NRTLTLFNVTRNDTASYKC 215 TLT+ V D A Y C Sbjct: 69 TVTLTISGVQAEDEADYYC 87 Score = 30.3 bits (66), Expect = 3.0, Method: Composition-based stats. Identities = 14/59 (23%), Positives = 24/59 (40%) Query: 427 YRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASG 485 +PG L + S P+ G+ T L IS + ++ Y CQ+ +S+ Sbjct: 37 QKPGQAPVLVIYKDSERPSGIPERFSGSSSGTTVTLTISGVQAEDEADYYCQSADSSGT 95 >1M71-B nrPDB Length = 220 Score = 36.5 bits (82), Expect = 0.042, Method: Composition-based stats. Identities = 16/86 (18%), Positives = 24/86 (27%), Gaps = 9/86 (10%) Query: 194 SNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRS-- 251 S + L + N+ DT Y C T+ + A T +P Sbjct: 77 SKSSVYLQMNNLRAEDTGIYYC-TRGGAVGAMDYWGQGTSVTVSSATTTAPSVYPLVPGC 135 Query: 252 ----GENLNLSCHAASN-PPA-QYSW 271 G ++ L C P W Sbjct: 136 SDTSGSSVTLGCLVKGYFPEPVTVKW 161 Score = 35.7 bits (80), Expect = 0.069, Method: Composition-based stats. Identities = 22/161 (13%), Positives = 44/161 (27%), Gaps = 42/161 (26%) Query: 416 DDPTISPSYTYYRPGVNLSLSCHAAS-------------NPPAQYSWLIDGNIQQHTQ-- 460 + +PG ++ LSC A+ +P W+ + ++ + Sbjct: 1 EVKVEESGGGLVQPGGSMKLSCVASGFTFSNYWMEWVRQSPEKGLEWVAEIRLKSNNYAT 60 Query: 461 --------ELFIS-------------NITEKNSGLYTCQANNSASGHSRTTVKT-ITVSA 498 IS N+ +++G+Y C + T +TVS+ Sbjct: 61 HYAESVKGRFTISRDDSKSSVYLQMNNLRAEDTGIYYCTRGGAVGAMDYWGQGTSVTVSS 120 Query: 499 ELP--KPSISSNNSKPVEDKDAVAFTCEPEA---QNTTYLW 534 +V C + + T W Sbjct: 121 ATTTAPSVYPLVPGCSDTSGSSVTLGCLVKGYFPEPVTVKW 161 Score = 32.6 bits (72), Expect = 0.64, Method: Composition-based stats. Identities = 29/204 (14%), Positives = 49/204 (24%), Gaps = 24/204 (11%) Query: 43 FNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYS--GREI 100 ++ + + W + G + + + A S GR Sbjct: 12 VQPGGSMKLSCVASGFTFSNYWMEWVRQSPEKGLEWVAEIRLKSNNYATHYAESVKGRFT 71 Query: 101 IYPNAS-----LLIQNIIQNDTGFYTL----HVIKSDLVNEEATGQFRVYPELPKPSISS 151 I + S L + N+ DTG Y V D + + Sbjct: 72 ISRDDSKSSVYLQMNNLRAEDTGIYYCTRGGAVGAMDYWGQGTSVTVSSATTTAPSVYPL 131 Query: 152 NNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTA 211 +V C + + N S +S+ + Sbjct: 132 VPGCSDTSGSSVTLGCLVKGYFPEPVTVKWNYGALSSGVRTVSS-----------VLQSG 180 Query: 212 SYKCE--TQNPVSARRSDSVILNV 233 Y P S S +VI NV Sbjct: 181 FYSLSSLVTVPSSTWPSQTVICNV 204 Score = 31.4 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 27/178 (15%), Positives = 48/178 (26%), Gaps = 42/178 (23%) Query: 512 PVEDKDAVAFTCEPEAQNTTYLWWV-------NGQSL-----------------PVSPRL 547 V+ ++ +C + W G V R Sbjct: 11 LVQPGGSMKLSCVASGFTFSNYWMEWVRQSPEKGLEWVAEIRLKSNNYATHYAESVKGRF 70 Query: 548 QLSNGNRT----LTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISP--- 600 +S + L + N+ D Y C +V A + +P Sbjct: 71 TISRDDSKSSVYLQMNNLRAEDTGIYYCTRGGAVGA-MDYWGQGTSVTVSSATTTAPSVY 129 Query: 601 ---PDSSYLSGANLNLSCHSASN-PSP-QYSWRINGIPQQHTQVLFIAKITPNNNGTY 653 P S SG+++ L C P P W + + V ++ + +G Y Sbjct: 130 PLVPGCSDTSGSSVTLGCLVKGYFPEPVTVKWNYGAL---SSGVRTVSSVL--QSGFY 182 >5MO9-X nrPDB Length = 151 Score = 36.5 bits (82), Expect = 0.043, Method: Composition-based stats. Identities = 15/72 (20%), Positives = 20/72 (27%), Gaps = 16/72 (22%) Query: 260 HAASNPPAQYSWFVNGTFQQSTQ----------------ELFIPNITVNNSGSYTCQAHN 303 NP WF NG ++ L + N T N+G YT A N Sbjct: 31 TVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 90 Query: 304 SDTGLNRTTVTT 315 + Sbjct: 91 EYGKDEKQISAH 102 Score = 34.1 bits (76), Expect = 0.19, Method: Composition-based stats. Identities = 26/121 (21%), Positives = 34/121 (28%), Gaps = 27/121 (22%) Query: 584 PVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQV---- 639 V L V + P + P S + + NP P W NG ++ Sbjct: 3 SVNLTVHFAPTITFLESPTSDHHWCIPFTVK----GNPKPALQWFYNGAILNESKYICTK 58 Query: 640 ------------LFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTS-PGLSAG 686 L + T NNG Y N I SA PG+ G Sbjct: 59 IHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQI------SAHFMGWPGIDDG 112 Query: 687 A 687 A Sbjct: 113 A 113 Score = 32.6 bits (72), Expect = 0.67, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 19/68 (27%), Gaps = 16/68 (23%) Query: 438 HAASNPPAQYSWLIDGNI---------QQHTQELF-------ISNITEKNSGLYTCQANN 481 NP W +G I + H + N T N+G YT A N Sbjct: 31 TVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKN 90 Query: 482 SASGHSRT 489 + Sbjct: 91 EYGKDEKQ 98 >1CCZ-A nrPDB Length = 171 Score = 36.5 bits (82), Expect = 0.044, Method: Composition-based stats. Identities = 24/160 (15%), Positives = 50/160 (31%), Gaps = 22/160 (13%) Query: 169 PETQDATYLWWVNNQS-------------LPVSPRLQLSNGNRTLTLFNVTRNDTASYKC 215 P + W + R+ L + +LT++N+T +D Y+ Sbjct: 18 PSNVPLKEVLWKKQKDKVAELENSEFRAFSSFKNRVYLDTVSGSLTIYNLTSSDEDEYEM 77 Query: 216 ETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNG 275 E+ N + +L ++ P Y N L+C + + Sbjct: 78 ESPNITDTMKFFLYVLEMVSKP---------MIYWECSNATLTCEVLEGTDVELKLYQGK 128 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTT 315 +S ++ + N + C+A N + + V Sbjct: 129 EHLRSLRQKTMSYQWTNLRAPFKCKAVNRVSQESEMEVVN 168 Score = 30.7 bits (67), Expect = 2.6, Method: Composition-based stats. Identities = 24/126 (19%), Positives = 38/126 (30%), Gaps = 18/126 (14%) Query: 105 ASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVA 164 SL I N+ +D Y + + + V + KP I + Sbjct: 60 GSLTIYNLTSSDEDEYEMESPN---ITDTMKFFLYVLEMVSKPMIYW-------ECSNAT 109 Query: 165 FTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSAR 224 TCE L + S R + + T N+ +KC+ N VS Sbjct: 110 LTCEVLEGTDVELKLYQGKEHLRSLRQKTMSYQWT----NLRAP----FKCKAVNRVSQE 161 Query: 225 RSDSVI 230 V+ Sbjct: 162 SEMEVV 167 >6IGW-A nrPDB Length = 135 Score = 36.1 bits (81), Expect = 0.053, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 27/68 (39%), Gaps = 5/68 (7%) Query: 263 SNPPA---QYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVY 319 N P + SW G + + I N+ ++G+Y C N + +T+ + V Sbjct: 63 GNYPPFKDRISWA--GDLDKKDASINIENMQFIHNGTYICDVKNPPDIVGKTSHIRLYVV 120 Query: 320 AEPPKPFI 327 + P + Sbjct: 121 EKENLPVL 128 Score = 34.9 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 21/119 (17%), Positives = 41/119 (34%), Gaps = 17/119 (14%) Query: 394 GIQNKLSVDHSDPVI------LNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPA-- 445 G Q KL+ ++ + P+ + + +Y G N P Sbjct: 16 GTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVGFFHYSQGQVYL------GNYPPFK 69 Query: 446 -QYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKP 503 + SW G++ + + I N+ ++G Y C N +T+ + V + P Sbjct: 70 DRISW--AGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVGKTSHIRLYVVEKENLP 126 Score = 33.0 bits (73), Expect = 0.47, Method: Composition-based stats. Identities = 19/92 (20%), Positives = 34/92 (36%), Gaps = 7/92 (7%) Query: 66 SW-YKGERVDGNRQIIGYVIGTQQATPGPAYSGR-----EIIYPNASLLIQNIIQNDTGF 119 SW ++ E D Y G P + R ++ +AS+ I+N+ G Sbjct: 38 SWSFQPEGADTTVGFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGT 97 Query: 120 YTLHVIK-SDLVNEEATGQFRVYPELPKPSIS 150 Y V D+V + + + V + P + Sbjct: 98 YICDVKNPPDIVGKTSHIRLYVVEKENLPVLE 129 Score = 30.7 bits (67), Expect = 2.6, Method: Composition-based stats. Identities = 15/106 (14%), Positives = 42/106 (39%), Gaps = 12/106 (11%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVN-------GQSLPVSPRLQLSNG----NR 554 ++ +V+++ +PE +TT ++ G P R+ + + Sbjct: 24 KFKSTSTTGGLTSVSWSFQPEGADTTVGFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDA 83 Query: 555 TLTLFNVTRNDARAYVCGIQNSVS-ANRSDPVTLDVLYGPDTPIIS 599 ++ + N+ Y+C ++N ++ + L V+ + P++ Sbjct: 84 SINIENMQFIHNGTYICDVKNPPDIVGKTSHIRLYVVEKENLPVLE 129 >3MOQ-A nrPDB Length = 126 Score = 36.1 bits (81), Expect = 0.059, Method: Composition-based stats. Identities = 22/102 (21%), Positives = 32/102 (31%), Gaps = 26/102 (25%) Query: 28 WNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQ 87 P T K T ES N ++ + L WY+ + N Q I Sbjct: 5 QTPRTATKETGESLTIN--------CVLRDASFELKDTGWYRTKLGSTNEQSI------- 49 Query: 88 QATPGPAYSGREIIYPNA-----SLLIQNIIQNDTGFYTLHV 124 + GR + N SL I ++ D+G Y Sbjct: 50 ------SIGGRYVETVNKGSKSFSLRISDLRVEDSGTYKCQA 85 Score = 32.6 bits (72), Expect = 0.66, Method: Composition-based stats. Identities = 12/81 (14%), Positives = 30/81 (37%), Gaps = 13/81 (16%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTYL---WWV------NGQSLPVSPRL--QLSNGNR 554 + + E +++ C + W+ N QS+ + R ++ G++ Sbjct: 5 QTPRTATKETGESLTINCVLRDASFELKDTGWYRTKLGSTNEQSISIGGRYVETVNKGSK 64 Query: 555 T--LTLFNVTRNDARAYVCGI 573 + L + ++ D+ Y C Sbjct: 65 SFSLRISDLRVEDSGTYKCQA 85 >3UEZ-A nrPDB Length = 208 Score = 36.1 bits (81), Expect = 0.062, Method: Composition-based stats. Identities = 13/91 (14%), Positives = 27/91 (29%), Gaps = 4/91 (4%) Query: 540 SLPVSPRLQLSNGNRT--LTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPI 597 P + T L + + Y+C ++ + L V+ + Sbjct: 51 EWPFRGFFDIHRSANTFFLVVTAANISHDGNYLCRMK-LGETEVTKQEHLSVVKPLTLSV 109 Query: 598 ISPPDSSYLSGANLNLSCHSASNPSPQYSWR 628 S + + L ++C + P P W Sbjct: 110 HSERSQ-FPDFSVLTVTCTVNAFPHPHVQWL 139 Score = 34.9 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 20/128 (15%), Positives = 42/128 (32%), Gaps = 8/128 (6%) Query: 66 SWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNAS---LLIQNIIQNDTGFYTL 122 SW+K G Q++ + + G I+ +A+ L++ + G Y Sbjct: 27 SWFKLG--PGEEQVLIGRMHHDVIFIEWPFRGFFDIHRSANTFFLVVTAANISHDGNYLC 84 Query: 123 HVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNN 182 + + E T Q + P + D + TC ++ W+ Sbjct: 85 RMKLGE---TEVTKQEHLSVVKPLTLSVHSERSQFPDFSVLTVTCTVNAFPHPHVQWLMP 141 Query: 183 QSLPVSPR 190 + + +P Sbjct: 142 EGVEPAPS 149 Score = 33.0 bits (73), Expect = 0.42, Method: Composition-based stats. Identities = 12/84 (14%), Positives = 25/84 (29%), Gaps = 12/84 (14%) Query: 194 SNGNRTLTLFNVTRNDTASYKCE---TQNPVSARRSDSVI--LNVLYGPDAPTISPLNTS 248 S L + + +Y C + V+ + SV+ L + + + Sbjct: 63 SANTFFLVVTAANISHDGNYLCRMKLGETEVTKQEHLSVVKPLTLSVHSERSQFPDFSV- 121 Query: 249 YRSGENLNLSCHAASNPPAQYSWF 272 L ++C + P W Sbjct: 122 ------LTVTCTVNAFPHPHVQWL 139 >3KHO-B nrPDB Length = 133 Score = 35.7 bits (80), Expect = 0.062, Method: Composition-based stats. Identities = 15/41 (36%), Positives = 18/41 (43%), Gaps = 3/41 (7%) Query: 85 GTQQATPGPAYSGREIIYPNAS---LLIQNIIQNDTGFYTL 122 G+QQ + GR + N S L IQNI D G Y Sbjct: 54 GSQQPQELVSEEGRIVQTQNGSVYTLTIQNIQYEDNGIYFC 94 >2IG2-H nrPDB Length = 455 Score = 35.7 bits (80), Expect = 0.067, Method: Composition-based stats. Identities = 67/412 (16%), Positives = 117/412 (28%), Gaps = 80/412 (19%) Query: 200 LTLFNVTRNDTASYKC-------ETQNPVSARRSDSVILNVLYGPDAPTISPL------N 246 L + ++ DT Y C + + A T P + Sbjct: 81 LQMDSLRPEDTGVYFCARDGGHGFCSSASCFGPDYWGQGTPVTVSSASTKGPSVFPLAPS 140 Query: 247 TSYRSGENLNLSCHAASN-PPA-QYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNS 304 + SG L C P SW P + + +SG Y+ + + Sbjct: 141 SKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVH---TFPAV-LQSSGLYSLSSVVT 196 Query: 305 DTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVAL----TCEPEIQNTTYLWWVNN 360 + T T I +N+ + + + TC P Sbjct: 197 VPSSSLGTQTYIC------NVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAP--------E 242 Query: 361 QSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTI 420 S L TL + C + VD S +DP + Sbjct: 243 LLGGPSVFLFPPKPKDTLMISRTP-----EVTCVV-----VDVSH----------EDPQV 282 Query: 421 SPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQAN 480 + +Y GV + +A + P Q + + L + + + Y C+ + Sbjct: 283 KFN--WYVDGVQVH---NAKTKPREQ----QYNSTYRVVSVLTVLHQNWLDGKEYKCKVS 333 Query: 481 NSASGHSRTTVKTITVSAELP--KPSISSNNSKPVEDKDAVAFTCEPEAQNT---TYLWW 535 N A KTI+ + P + S+ K+ V+ TC + W Sbjct: 334 NKA--LPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWE 391 Query: 536 VNGQSL---PVSPRLQLSNGN----RTLTLFNVTRNDARAYVCGIQNSVSAN 580 NGQ +P + S+G+ LT+ + C + + N Sbjct: 392 SNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHN 443 Score = 34.1 bits (76), Expect = 0.22, Method: Composition-based stats. Identities = 51/392 (13%), Positives = 107/392 (27%), Gaps = 76/392 (19%) Query: 97 GREIIYPNAS-----LLIQNIIQNDTGFYTLHVIKSDLVNEEATGQ-FRVYPELPKPSIS 150 GR I N S L + ++ DTG Y A+ + + ++S Sbjct: 66 GRFTISRNDSKNTLFLQMDSLRPEDTGVYFCARDGGHGFCSSASCFGPDYWGQGTPVTVS 125 Query: 151 SNN-----------SKPVEDKDAVAFTCEPE-TQDAT-YLWWVNNQSLPVSPRLQLSNGN 197 S + S A C + + W + + Sbjct: 126 SASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVHTFPAVLQS 185 Query: 198 RTLTLFNVTRND------TASYKCETQN-PVSARRSDSVILNVLY--GPDAPTISPL--- 245 L + T +Y C + P + + V P +P Sbjct: 186 SGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLG 245 Query: 246 -----------NTSYRSGENLNLSCHAASN----PPAQYSWFVNGTFQQSTQE------- 283 + ++C P +++W+V+G + + Sbjct: 246 GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPQVKFNWYVDGVQVHNAKTKPREQQY 305 Query: 284 ---------LFIPNITVNNSGSYTCQAHNSDTGLN-RTTVTTITVYAEPPKPFITSNNSN 333 L + + + Y C+ N T++ P+ + + Sbjct: 306 NSTYRVVSVLTVLHQNWLDGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRE 365 Query: 334 PVEDEDAVALTCEPEIQNTT--YLWWVNNQSLPVSPRLQLS---NDNRTLTLLS-----V 383 + V+LTC + + + W +N P + + + + L S Sbjct: 366 EMTKNQ-VSLTCLVKGFYPSDIAVEWESNG-QPENNYKTTPPVLDSDGSFFLYSKLTVDK 423 Query: 384 TRNDVGP-YECGIQNKLSVDHSDPVILNVLYG 414 +R G + C + ++ +H L++ G Sbjct: 424 SRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG 455 >1QFW-L nrPDB Length = 114 Score = 35.7 bits (80), Expect = 0.069, Method: Composition-based stats. Identities = 15/88 (17%), Positives = 22/88 (25%), Gaps = 21/88 (23%) Query: 506 SSNNSKPVEDKDAVAFTCEP------------------EAQNTTYLWWVN---GQSLPVS 544 S +S V +C Q L + +P Sbjct: 6 QSPDSLAVSLGQRATISCRASESVDSYGNSFMQWYQQKPGQPPKLLIYRASNLESGIPAR 65 Query: 545 PRLQLSNGNRTLTLFNVTRNDARAYVCG 572 S + TLT+ V +D Y C Sbjct: 66 FSGTGSRTDFTLTINPVEADDVATYYCQ 93 >5MZA-B nrPDB Length = 186 Score = 35.3 bits (79), Expect = 0.082, Method: Composition-based stats. Identities = 21/120 (17%), Positives = 39/120 (32%), Gaps = 5/120 (4%) Query: 503 PSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVT 562 + S + + +V TC L ++ L L NR + + Sbjct: 1 QTSVSPSKVILPRGGSVLVTCSTSCDQPKLL---GIETPLPKKELLLPGNNRKVYELSNV 57 Query: 563 RNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPS 622 + D++ +C + + L V + P+ ++P S G NL L C Sbjct: 58 QEDSQP-MCYSNCPDGQSTAKTF-LTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAP 115 Score = 32.2 bits (71), Expect = 0.71, Method: Composition-based stats. Identities = 29/158 (18%), Positives = 47/158 (29%), Gaps = 7/158 (4%) Query: 159 DKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ 218 +V TC L LP L N + L NV + C + Sbjct: 13 RGGSVLVTCSTSCDQPKLLGI--ETPLPKKELLLPGNNRKVYELSNVQEDSQPM--CYSN 68 Query: 219 NPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQ 278 P + + L V + P+ ++PL + G+NL L C P + Sbjct: 69 CPDGQSTAKT-FLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRAN--LTVVLLR 125 Query: 279 QSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTI 316 + P + + T G N + T + Sbjct: 126 GEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTEL 163 >1CF8-L nrPDB Length = 215 Score = 35.3 bits (79), Expect = 0.088, Method: Composition-based stats. Identities = 34/196 (17%), Positives = 64/196 (32%), Gaps = 42/196 (21%) Query: 155 KPVEDKDAVAFTCEPETQDAT-YLWWVNNQS-----------------LPVSPRLQLSNG 196 V + V TC + ++ Y++W + +P S Sbjct: 11 MSVSPGEKVTLTCSASSSVSSNYVYWYQQKPGSSPKVWIYSTSNLASGVPARFSGSGSGT 70 Query: 197 NRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTSYRSGE 253 + +LT+ ++ D ASY C + L + APT+S P + SG Sbjct: 71 SYSLTISSMEAEDAASYFCLQWSSFPYTFGGGTKLELKRADVAPTVSIFPPSSEQLTSG- 129 Query: 254 NLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFIPNITVNN 293 ++ C + P W ++G+ +Q+ + L + Sbjct: 130 GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYER 189 Query: 294 SGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 190 HNSYTCEATHKTSTSP 205 Score = 32.2 bits (71), Expect = 0.87, Method: Composition-based stats. Identities = 34/199 (17%), Positives = 56/199 (28%), Gaps = 38/199 (19%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQY-SWFVN------GTFQQSTQ----------- 282 T SP S GE + L+C A+S+ + Y W+ + ST Sbjct: 5 TQSPTIMSVSPGEKVTLTCSASSSVSSNYVYWYQQKPGSSPKVWIYSTSNLASGVPARFS 64 Query: 283 --------ELFIPNITVNNSGSYTCQAHNSD--TGLNRTTVTTITVYAEPPKPFITSNNS 332 L I ++ ++ SY C +S T T + P ++ Sbjct: 65 GSGSGTSYSLTISSMEAEDAASYFCLQWSSFPYTFGGGTKLELKRADVAPTVSIFPPSSE 124 Query: 333 NPVEDEDAVALTCEPEIQNTTYLWWVNNQS----------LPVSPRLQLSNDNRTLTLLS 382 +V + W + S + + + TLTL Sbjct: 125 QLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTK 184 Query: 383 VTRNDVGPYECGIQNKLSV 401 Y C +K S Sbjct: 185 DEYERHNSYTCEATHKTST 203 Score = 30.3 bits (66), Expect = 3.4, Method: Composition-based stats. Identities = 29/204 (14%), Positives = 57/204 (27%), Gaps = 50/204 (24%) Query: 419 TISPSYTYYRPGVNLSLSCHAA---------------SNPPAQYSW----LIDGNIQQH- 458 T SP+ PG ++L+C A+ + P + + L G + Sbjct: 5 TQSPTIMSVSPGEKVTLTCSASSSVSSNYVYWYQQKPGSSPKVWIYSTSNLASGVPARFS 64 Query: 459 ------TQELFISNITEKNSGLYTCQA------NNSASGHSRTTVKTITVSAELPKPSIS 506 + L IS++ +++ Y C + + + PS Sbjct: 65 GSGSGTSYSLTISSMEAEDAASYFCLQWSSFPYTFGGGTKLELKRADVAPTVSIFPPS-- 122 Query: 507 SNNSKPVEDKDAVAFTCEPEAQNTT---YLWWVNGQSLPV---------SPRLQLSNGNR 554 + + +V C W ++G + + + Sbjct: 123 --SEQLTSGGASVV--CFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSS 178 Query: 555 TLTLFNVTRNDARAYVCGIQNSVS 578 TLTL +Y C + S Sbjct: 179 TLTLTKDEYERHNSYTCEATHKTS 202 >5K8D-B nrPDB Length = 865 Score = 35.3 bits (79), Expect = 0.099, Method: Composition-based stats. Identities = 30/167 (17%), Positives = 59/167 (35%), Gaps = 30/167 (17%) Query: 442 NPPAQYSWLIDG----------NIQQHTQELFISNI-----TEKNSGL-YTCQANNSASG 485 +P +++W +DG +Q+ + ++ + +G Y C+ +N A Sbjct: 689 DPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKA-- 746 Query: 486 HSRTTVKTITVSAELP--KPSISSNNSKPVEDKDAVAFTCEPEAQNT---TYLWWVNGQS 540 KTI+ + P + S+ K+ V+ TC + W NGQ Sbjct: 747 LPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQP 806 Query: 541 L---PVSPRLQLSNGN----RTLTLFNVTRNDARAYVCGIQNSVSAN 580 +P + S+G+ LT+ + C + + N Sbjct: 807 ENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHN 853 >1QFW-M nrPDB Length = 108 Score = 35.3 bits (79), Expect = 0.099, Method: Composition-based stats. Identities = 18/87 (20%), Positives = 27/87 (31%), Gaps = 17/87 (19%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNR-------- 376 S S + + V L+C+ +++ W + L NR Sbjct: 3 ELTQSPKSMSMSVGERVTLSCKASETVDSFVSWYQQKPEQSPKLLIFGASNRFSGVPDRF 62 Query: 377 ---------TLTLLSVTRNDVGPYECG 394 TLT+ SV D Y CG Sbjct: 63 TGSGSATDFTLTISSVQAEDFADYHCG 89 Score = 31.1 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 16/87 (18%), Positives = 29/87 (33%), Gaps = 19/87 (21%) Query: 147 PSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNR-------- 198 S S + + V +C+ +++ W + SP+L + + Sbjct: 3 ELTQSPKSMSMSVGERVTLSCKASETVDSFVSWYQQKPE-QSPKLLIFGASNRFSGVPDR 61 Query: 199 ----------TLTLFNVTRNDTASYKC 215 TLT+ +V D A Y C Sbjct: 62 FTGSGSATDFTLTISSVQAEDFADYHC 88 >1MQ8-A nrPDB Length = 291 Score = 35.3 bits (79), Expect = 0.10, Method: Composition-based stats. Identities = 21/120 (17%), Positives = 39/120 (32%), Gaps = 5/120 (4%) Query: 503 PSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVT 562 + S + + +V TC L ++ L L NR + + Sbjct: 1 QTSVSPSKVILPRGGSVLVTCSTSCDQPKLL---GIETPLPKKELLLPGNNRKVYELSNV 57 Query: 563 RNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPS 622 + D++ +C + + L V + P+ ++P S G NL L C Sbjct: 58 QEDSQP-MCYSNCPDGQSTAKTF-LTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAP 115 Score = 32.2 bits (71), Expect = 0.84, Method: Composition-based stats. Identities = 29/158 (18%), Positives = 47/158 (29%), Gaps = 7/158 (4%) Query: 159 DKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ 218 +V TC L LP L N + L NV + C + Sbjct: 13 RGGSVLVTCSTSCDQPKLLGI--ETPLPKKELLLPGNNRKVYELSNVQEDSQPM--CYSN 68 Query: 219 NPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQ 278 P + + L V + P+ ++PL + G+NL L C P + Sbjct: 69 CPDGQSTAKT-FLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRAN--LTVVLLR 125 Query: 279 QSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTI 316 + P + + T G N + T + Sbjct: 126 GEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTEL 163 >1I7Z-A nrPDB Length = 219 Score = 34.9 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 31/219 (14%), Positives = 60/219 (27%), Gaps = 33/219 (15%) Query: 149 ISSNNSKPVEDKDAVAFTCEPETQDAT----YLWWVNNQS-----------------LPV 187 S S V +C +T Y+ W + +P Sbjct: 5 TQSPASLAVSLGQRATISCRASKSVSTSGYNYMHWYQQKPGQPPKLLIYLASNLASGVPA 64 Query: 188 SPRLQLSNGNRTLTLFNVTRNDTASYKCETQN-----PVSARRSDSVILNVLYGPDAPTI 242 S + TL + V D A+Y C + V P Sbjct: 65 RFSGSGSGTDFTLNIHPVEEEDAATYYCLYSREFPPWTFGGGTKLEIKRTVA-APSVFIF 123 Query: 243 SPLNTSYRSGENLNLSCHAASNPP--AQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQ 300 P + +SG ++ C + P A+ W V+ Q + + +S +Y+ Sbjct: 124 PPSDEQLKSG-TASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS-TYSLS 181 Query: 301 AHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDED 339 + + + + E ++S + + Sbjct: 182 STLTLSKADYEK--HKVYACEVTHQGLSSPVTKSFNRGE 218 >5EU6-D nrPDB Length = 204 Score = 34.9 bits (78), Expect = 0.13, Method: Composition-based stats. Identities = 22/131 (16%), Positives = 45/131 (34%), Gaps = 6/131 (4%) Query: 43 FNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIY 102 +V EG+ ++L ++ W++ + G ++ ++ T G + + Sbjct: 12 LSVPEGENLVLNCSFTDSAIYNLQWFRQDPGKGLTSLLLIQSSQREQTSGRLNASLDKSS 71 Query: 103 PNASLLIQNIIQNDTGFYTLHVIKSDLVNEEAT------GQFRVYPELPKPSISSNNSKP 156 ++L I D+ Y V+ S N + T + P P++ Sbjct: 72 GRSTLYIAASQPGDSATYLCAVLSSGGSNYKLTFGKGTLLTVNPNIQNPDPAVYQLRDSK 131 Query: 157 VEDKDAVAFTC 167 DK FT Sbjct: 132 SSDKSVCLFTD 142 Score = 33.0 bits (73), Expect = 0.46, Method: Composition-based stats. Identities = 23/127 (18%), Positives = 33/127 (25%), Gaps = 27/127 (21%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN---------------------GTFQQ 279 T P S GENL L+C + WF G Sbjct: 6 TQIPAALSVPEGENLVLNCSFTDSAIYNLQWFRQDPGKGLTSLLLIQSSQREQTSGRLNA 65 Query: 280 S------TQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSN 333 S L+I +S +Y C +S + T T+ P Sbjct: 66 SLDKSSGRSTLYIAASQPGDSATYLCAVLSSGGSNYKLTFGKGTLLTVNPNIQNPDPAVY 125 Query: 334 PVEDEDA 340 + D + Sbjct: 126 QLRDSKS 132 >5XCV-B nrPDB Length = 165 Score = 34.5 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 18/94 (19%), Positives = 31/94 (32%), Gaps = 6/94 (6%) Query: 40 STPFNVAEGKEVLLL--VHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSG 97 S N+ ++ N+ + +WY+ +I P +SG Sbjct: 13 SVSTNLGSTVKLSCKRSTGNIGSNYV--NWYQQHEGRSPTTMIYRDDKRPDGVPD-RFSG 69 Query: 98 REIIYPNASL-LIQNIIQNDTGFYTLHVIKSDLV 130 N++L I N+ D Y H S +V Sbjct: 70 SIDRSSNSALLTINNVQTEDEADYFCHSYSSGIV 103 >5MXA-A nrPDB Length = 328 Score = 34.5 bits (77), Expect = 0.16, Method: Composition-based stats. Identities = 13/53 (24%), Positives = 21/53 (39%), Gaps = 6/53 (11%) Query: 251 SGENLNLSCHAASNPPAQ-YSWFVN--GTFQQSTQELFIPNITVNNSGSYTCQ 300 GE + L+C P +W ++ S + L I ++G YTC Sbjct: 42 PGEMVVLTCDT---PEEDGITWTLDQSSEVLGSGKTLTIQVKEFGDAGQYTCH 91 Score = 32.6 bits (72), Expect = 0.53, Method: Composition-based stats. Identities = 12/61 (19%), Positives = 21/61 (34%), Gaps = 8/61 (13%) Query: 511 KPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYV 570 P + V TC+ +G + + ++ +TLT+ DA Y Sbjct: 38 YPDAPGEMVVLTCDTPE--------EDGITWTLDQSSEVLGSGKTLTIQVKEFGDAGQYT 89 Query: 571 C 571 C Sbjct: 90 C 90 Score = 31.8 bits (70), Expect = 0.91, Method: Composition-based stats. Identities = 23/172 (13%), Positives = 46/172 (26%), Gaps = 15/172 (8%) Query: 428 RPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHS 487 PG + L+C ++ + + L I ++G YTC G Sbjct: 41 APGEMVVLTCDTPEEDGITWTLDQSSEVLGSGKTLTIQVKEFGDAGQYTC----HKGGEV 96 Query: 488 RTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEP---EAQNTTYLWWVNGQSLPVS 544 + + E S + CE + T WW+ ++ Sbjct: 97 LSHSLLLLHKKEDGIWSTDILKDQKEPKNKT-FLRCEAKNYSGRFT--CWWL--TTISTD 151 Query: 545 PRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTP 596 + + + VT A + N+ +++ P Sbjct: 152 LTFSVKSSRGSSDPQGVT---CGAATLSAERVRGDNKEYEYSVECQEDSACP 200 >5XSY-B nrPDB Length = 209 Score = 34.5 bits (77), Expect = 0.16, Method: Composition-based stats. Identities = 13/56 (23%), Positives = 24/56 (42%), Gaps = 5/56 (8%) Query: 189 PRLQLSNGNRTLTLFNVTRNDTASYKC-----ETQNPVSARRSDSVILNVLYGPDA 239 + + ++ + NVT NDT +Y+C T N R + + + + P A Sbjct: 98 SKNTFDLQDGSIYILNVTLNDTGTYRCYFDRTLTFNYYEFRTNINKTITLNVVPKA 153 Score = 31.8 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 22/50 (44%), Gaps = 8/50 (16%) Query: 276 TFQQSTQELFIPNITVNNSGSYTCQAHN--------SDTGLNRTTVTTIT 317 TF ++I N+T+N++G+Y C T +N+T + Sbjct: 101 TFDLQDGSIYILNVTLNDTGTYRCYFDRTLTFNYYEFRTNINKTITLNVV 150 >25C8-L nrPDB Length = 212 Score = 34.5 bits (77), Expect = 0.17, Method: Composition-based stats. Identities = 39/205 (19%), Positives = 59/205 (28%), Gaps = 50/205 (24%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQ-YSWFVNG------TFQQSTQ----------- 282 T SP S GE + ++C A+S+ + W+ + ST Sbjct: 5 TQSPAIMSASLGERVTMTCTASSSVSSSNLHWYQQKPGSSPKLWIYSTSNLASGVPARFS 64 Query: 283 --------ELFIPNITVNNSGSYTC-QAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSN 333 L I ++ ++ +Y C Q H S T I P I +S Sbjct: 65 GSGSGTSYSLTISSMEAEDAATYYCHQYHRSPYTFGGGTKLEIKRADAAPTVSIFPPSSE 124 Query: 334 PVEDEDAVALTC-----------------EPEIQNTTYLWWVNNQSLPVSPRLQLSNDNR 376 + ++ C E QN L +Q S + Sbjct: 125 QLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQNGV-LNSWTDQDSKDSTYSM----SS 178 Query: 377 TLTLLSVTRNDVGPYECGIQNKLSV 401 TLTL Y C +K S Sbjct: 179 TLTLTKDEYERHNSYTCEATHKTST 203 Score = 34.1 bits (76), Expect = 0.22, Method: Composition-based stats. Identities = 32/196 (16%), Positives = 61/196 (31%), Gaps = 42/196 (21%) Query: 155 KPVEDKDAVAFTCEPET--------------QDATYLWWVNNQS----LPVSPRLQLSNG 196 + V TC + + LW + + +P S Sbjct: 11 MSASLGERVTMTCTASSSVSSSNLHWYQQKPGSSPKLWIYSTSNLASGVPARFSGSGSGT 70 Query: 197 NRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTIS---PLNTSYRSGE 253 + +LT+ ++ D A+Y C + L + APT+S P + SG Sbjct: 71 SYSLTISSMEAEDAATYYCHQYHRSPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSG- 129 Query: 254 NLNLSCHAASNPPAQY--SWFVNGTFQQS------------------TQELFIPNITVNN 293 ++ C + P W ++G+ +Q+ + L + Sbjct: 130 GASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYER 189 Query: 294 SGSYTCQAHNSDTGLN 309 SYTC+A + + Sbjct: 190 HNSYTCEATHKTSTSP 205 Score = 31.8 bits (70), Expect = 0.92, Method: Composition-based stats. Identities = 27/165 (16%), Positives = 53/165 (32%), Gaps = 14/165 (8%) Query: 427 YRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSAS-G 485 +PG + L ++ SN + G+ + L IS++ +++ Y C + + Sbjct: 39 QKPGSSPKLWIYSTSNLASGVPARFSGSGSGTSYSLTISSMEAEDAATYYCHQYHRSPYT 98 Query: 486 HSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTT---YLWWVNGQSLP 542 T I + P SI +S+ + + C W ++G Sbjct: 99 FGGGTKLEIKRADAAPTVSIFPPSSEQLTSG-GASVVCFLNNFYPKDINVKWKIDGSERQ 157 Query: 543 V---------SPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVS 578 + + + TLTL +Y C + S Sbjct: 158 NGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTS 202 >1HZH-H nrPDB Length = 457 Score = 34.5 bits (77), Expect = 0.18, Method: Composition-based stats. Identities = 72/419 (17%), Positives = 121/419 (28%), Gaps = 81/419 (19%) Query: 194 SNGNRTLTLFNVTRNDTASYKCETQNPVSARRS--------DSVILNVLYGPDAPTISPL 245 S + L ++ DTA Y C P S S + A T P Sbjct: 75 SANTAYMELRSLRSADTAVYYCARVGPYSWDDSPQDNYYMDVWGKGTTVIVSSASTKGPS 134 Query: 246 ------NTSYRSGENLNLSCHAASN-PPA-QYSWFVNGTFQQSTQELFIPNITVNNSGSY 297 ++ SG L C P SW P + + +SG Y Sbjct: 135 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVH---TFPAV-LQSSGLY 190 Query: 298 TCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVAL----TCEPEIQNTT 353 + + + + T T I +N+ + + + TC P Sbjct: 191 SLSSVVTVPSSSLGTQTYIC------NVNHKPSNTKVDKKAEPKSCDKTHTCPPCPAP-- 242 Query: 354 YLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLY 413 S L TL + C + VD S Sbjct: 243 ------ELLGGPSVFLFPPKPKDTLMISRTP-----EVTCVV-----VDVSH-------- 278 Query: 414 GPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSG 473 +DP + + +Y GV + +A + P + + + L + + N Sbjct: 279 --EDPEVKFN--WYVDGVEVH---NAKTKPREE----QYNSTYRVVSVLTVLHQDWLNGK 327 Query: 474 LYTCQANNSASGHSRTTVKTITVSAELP--KPSISSNNSKPVEDKDAVAFTCEPEAQNT- 530 Y C+ +N A KTI+ + P + S+ K+ V+ TC + Sbjct: 328 EYKCKVSNKA--LPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPS 385 Query: 531 --TYLWWVNGQSL---PVSPRLQLSNGN----RTLTLFNVTRNDARAYVCGIQNSVSAN 580 W NGQ +P + S+G+ LT+ + C + + N Sbjct: 386 DIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHN 444 >5V52-C nrPDB Length = 140 Score = 34.1 bits (76), Expect = 0.18, Method: Composition-based stats. Identities = 9/40 (22%), Positives = 16/40 (40%) Query: 274 NGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTV 313 + + L + +TV + G+YTC+ G R Sbjct: 84 DTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMT 123 Score = 31.1 bits (68), Expect = 2.0, Method: Composition-based stats. Identities = 18/81 (22%), Positives = 29/81 (35%), Gaps = 7/81 (8%) Query: 418 PTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTC 477 P + PS+ +PG S A+ S D + L + +T ++ G YTC Sbjct: 56 PKMGPSFPSPKPGS------ERLSFVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTC 109 Query: 478 Q-ANNSASGHSRTTVKTITVS 497 + A T + V Sbjct: 110 EFATFPKGSVRGMTWLRVLVP 130 >3F7R-A nrPDB Length = 249 Score = 34.1 bits (76), Expect = 0.19, Method: Composition-based stats. Identities = 20/128 (15%), Positives = 40/128 (31%), Gaps = 12/128 (9%) Query: 117 TGFYTLHV---IKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQD 173 G Y+ V ++ +E F V + ++ + A D Sbjct: 83 EGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDD 142 Query: 174 ATYLWWVNNQSLPVSPRLQLSN-GNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILN 232 N+ + ++ + N NR L + N+ + Y + +N I+N Sbjct: 143 --------NRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIIN 194 Query: 233 VLYGPDAP 240 + P P Sbjct: 195 LATQPKRP 202 >5XCV-A nrPDB Length = 172 Score = 34.1 bits (76), Expect = 0.19, Method: Composition-based stats. Identities = 13/89 (14%), Positives = 25/89 (28%), Gaps = 5/89 (5%) Query: 43 FNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIY 102 ++ +G +W + G I G + G + GR I Sbjct: 16 VQPGRSLKLSCAASGFTFSNYGMAWVRQTPTKGLEWIASISAGGDKTYYGDSVKGRFSIS 75 Query: 103 PNAS-----LLIQNIIQNDTGFYTLHVIK 126 + + L + ++ DT Y Sbjct: 76 RDNAKTTHYLQMDSLRSEDTATYYCAKTS 104 >1I8K-A nrPDB Length = 107 Score = 34.1 bits (76), Expect = 0.19, Method: Composition-based stats. Identities = 18/104 (17%), Positives = 29/104 (27%), Gaps = 17/104 (16%) Query: 325 PFITSNNSNPVEDEDAVALTC--------------EPEIQNTTYLWWVNNQSLPVSPRLQ 370 S S V + V + C + + +L N P P Sbjct: 3 ELTQSPASLSVATGEKVTIRCMTSTDIDDDMNWYQQKPGEPPKFLISEGNTLRPGVPSRF 62 Query: 371 LSNDNRT---LTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNV 411 S+ T T+ + DVG Y C + + L + Sbjct: 63 SSSGTGTDFVFTIENTLSEDVGDYYCLQSFNVPLTFGCGTKLEI 106 Score = 31.1 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 16/83 (19%), Positives = 21/83 (25%), Gaps = 17/83 (20%) Query: 506 SSNNSKPVEDKDAVAFTCEP--------------EAQNTTYLWWVNGQSLPVSPRLQLSN 551 S S V + V C + +L P P S+ Sbjct: 6 QSPASLSVATGEKVTIRCMTSTDIDDDMNWYQQKPGEPPKFLISEGNTLRPGVPSRFSSS 65 Query: 552 GNRT---LTLFNVTRNDARAYVC 571 G T T+ N D Y C Sbjct: 66 GTGTDFVFTIENTLSEDVGDYYC 88 >4CKD-L nrPDB Length = 107 Score = 34.1 bits (76), Expect = 0.20, Method: Composition-based stats. Identities = 19/89 (21%), Positives = 30/89 (33%), Gaps = 25/89 (28%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP S G +++LSC A+ + W+ G Sbjct: 5 TQSPATLSVTPGNSVSLSCRASQSIGNDLHWYQQKSHESPRLLIKYASQSISGIPSRFSG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQAHNS 304 + + L I ++ + G Y CQ NS Sbjct: 65 SGSGTDFTLSINSVETEDFGMYFCQQSNS 93 Score = 33.8 bits (75), Expect = 0.26, Method: Composition-based stats. Identities = 22/92 (23%), Positives = 32/92 (34%), Gaps = 19/92 (20%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQL------------- 371 S + V ++V+L+C L W +S SPRL + Sbjct: 3 VLTQSPATLSVTPGNSVSLSCRASQSIGNDLHWYQQKSH-ESPRLLIKYASQSISGIPSR 61 Query: 372 -----SNDNRTLTLLSVTRNDVGPYECGIQNK 398 S + TL++ SV D G Y C N Sbjct: 62 FSGSGSGTDFTLSINSVETEDFGMYFCQQSNS 93 Score = 33.8 bits (75), Expect = 0.27, Method: Composition-based stats. Identities = 21/89 (23%), Positives = 35/89 (39%), Gaps = 25/89 (28%) Query: 419 TISPSYTYYRPGVNLSLSCHAASNPPAQYSWL------------------IDGNIQQHTQ 460 T SP+ PG ++SLSC A+ + W I G + + Sbjct: 5 TQSPATLSVTPGNSVSLSCRASQSIGNDLHWYQQKSHESPRLLIKYASQSISGIPSRFSG 64 Query: 461 -------ELFISNITEKNSGLYTCQANNS 482 L I+++ ++ G+Y CQ +NS Sbjct: 65 SGSGTDFTLSINSVETEDFGMYFCQQSNS 93 Score = 32.2 bits (71), Expect = 0.76, Method: Composition-based stats. Identities = 20/94 (21%), Positives = 31/94 (32%), Gaps = 2/94 (2%) Query: 34 AKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGP 93 LT +V G V L WY+ + + R +I Y + P Sbjct: 2 IVLTQSPATLSVTPGNSVSLSCRASQSIGNDLHWYQQKSHESPRLLIKYASQSISGIPS- 60 Query: 94 AYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKS 127 +SG + +L I ++ D G Y S Sbjct: 61 RFSGSGSGT-DFTLSINSVETEDFGMYFCQQSNS 93 Score = 30.3 bits (66), Expect = 3.0, Method: Composition-based stats. Identities = 19/87 (21%), Positives = 30/87 (34%), Gaps = 25/87 (28%) Query: 599 SPPDSSYLSGANLNLSCHSASNPSPQYSWR------------------INGIPQQHTQ-- 638 SP S G +++LSC ++ + W I+GIP + + Sbjct: 7 SPATLSVTPGNSVSLSCRASQSIGNDLHWYQQKSHESPRLLIKYASQSISGIPSRFSGSG 66 Query: 639 -----VLFIAKITPNNNGTYACFVSNL 660 L I + + G Y C SN Sbjct: 67 SGTDFTLSINSVETEDFGMYFCQQSNS 93 >1DVF-C nrPDB Length = 107 Score = 34.1 bits (76), Expect = 0.23, Method: Composition-based stats. Identities = 17/88 (19%), Positives = 30/88 (34%), Gaps = 25/88 (28%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP + S G+ + +SC A+ + +W+ G Sbjct: 5 TQSPSSLSASLGDRVTISCRASQDISNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSRFSG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQAHN 303 + + L I N+ + +Y CQ N Sbjct: 65 SGSGTDYSLTISNLEQEDIATYFCQQGN 92 Score = 34.1 bits (76), Expect = 0.23, Method: Composition-based stats. Identities = 16/89 (17%), Positives = 28/89 (31%), Gaps = 17/89 (19%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTY-LWWVNG----------------QSLPVSPRLQ 548 S +S D V +C + Y W+ +P Sbjct: 6 QSPSSLSASLGDRVTISCRASQDISNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCGIQNSV 577 S + +LT+ N+ + D Y C N++ Sbjct: 66 GSGTDYSLTISNLEQEDIATYFCQQGNTL 94 Score = 33.0 bits (73), Expect = 0.50, Method: Composition-based stats. Identities = 17/91 (18%), Positives = 29/91 (31%), Gaps = 17/91 (18%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRL---------------- 369 S +S D V ++C + YL W + L Sbjct: 4 LTQSPSSLSASLGDRVTISCRASQDISNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSRFS 63 Query: 370 -QLSNDNRTLTLLSVTRNDVGPYECGIQNKL 399 S + +LT+ ++ + D+ Y C N L Sbjct: 64 GSGSGTDYSLTISNLEQEDIATYFCQQGNTL 94 Score = 32.2 bits (71), Expect = 0.74, Method: Composition-based stats. Identities = 18/90 (20%), Positives = 31/90 (34%), Gaps = 17/90 (18%) Query: 149 ISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRL 191 S +S D V +C + YL W + +P Sbjct: 5 TQSPSSLSASLGDRVTISCRASQDISNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSRFSG 64 Query: 192 QLSNGNRTLTLFNVTRNDTASYKCETQNPV 221 S + +LT+ N+ + D A+Y C+ N + Sbjct: 65 SGSGTDYSLTISNLEQEDIATYFCQQGNTL 94 Score = 32.2 bits (71), Expect = 0.77, Method: Composition-based stats. Identities = 20/91 (21%), Positives = 37/91 (40%), Gaps = 4/91 (4%) Query: 34 AKLTIESTPFNVAEGKEVLLLVHNLPQHLFGY-SWYKGERVDGNRQIIGYVIGTQQATPG 92 +LT + + + G V + Q + Y +WY+ ++ DG +++ Y + Sbjct: 2 IQLTQSPSSLSASLGDRVTISCRA-SQDISNYLNWYQ-QKPDGTVKLLIYYTSRLHSGVP 59 Query: 93 PAYSGREIIYPNASLLIQNIIQNDTGFYTLH 123 +SG + SL I N+ Q D Y Sbjct: 60 SRFSGSGSGT-DYSLTISNLEQEDIATYFCQ 89 >1BII-A nrPDB Length = 365 Score = 33.8 bits (75), Expect = 0.30, Method: Composition-based stats. Identities = 22/120 (18%), Positives = 33/120 (27%), Gaps = 19/120 (15%) Query: 232 NVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQSTQELFIPN- 288 N P + + R ++ L C A PA +W +NG EL Sbjct: 200 NATLLRTDPPKAHVTHHRRPEGDVTLRCWALGFYPADITLTWQLNGEELTQEMELVETRP 259 Query: 289 -------------ITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPV 335 + + YTC + +T EPP T+ V Sbjct: 260 AGDGTFQKWASVVVPLGKEQKYTCHVEHEGLPEP---LTLRWGKEEPPSSTKTNTVIIAV 316 >1ZVO-C nrPDB Length = 512 Score = 33.4 bits (74), Expect = 0.31, Method: Composition-based stats. Identities = 26/148 (17%), Positives = 50/148 (33%), Gaps = 22/148 (14%) Query: 283 ELFIPNITVNNSGSYTC----------QAHNSDTGLNRTTV-TTITVYAEPPKPFITSNN 331 L + +++ ++ Y C SD G++ TT+ V + P K Sbjct: 81 SLNLRSMSAADTAMYYCARGNPPPYYDIGTGSDDGIDVWGQGTTVHVSSAPTKAPDVFPI 140 Query: 332 SNPVE---DEDAVALTCEPEIQNTTYL---WWVNNQSLPVSPRLQLSNDNRTLTLLS--- 382 + D V L C + T + W++ QS P ++ + S Sbjct: 141 ISGCRHPKDNSPVVLACLITGYHPTSVTVTWYMGTQSQPQRTFPEIQRRDSYYMTSSQLS 200 Query: 383 --VTRNDVGPYECGIQNKLSVDHSDPVI 408 + + G Y+C +Q+ S + Sbjct: 201 TPLQQWRQGEYKCVVQHTASKSKKEIFR 228 >5HHM-D nrPDB Length = 200 Score = 33.4 bits (74), Expect = 0.34, Method: Composition-based stats. Identities = 19/111 (17%), Positives = 33/111 (29%), Gaps = 6/111 (5%) Query: 42 PFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREII 101 E V ++ L WY+ E +G ++ V G + Sbjct: 11 SIQEGENLTVYCNSSSVFSSL---QWYRQEPGEGPVLLVTVVTGGEVKKLKRLTFQFGDA 67 Query: 102 YPNASLLIQNIIQNDTGFYTLHVIKSDL---VNEEATGQFRVYPELPKPSI 149 ++SL I DTG Y S + + + P P++ Sbjct: 68 RKDSSLHITAAQPGDTGLYLCAGAGSQGNLIFGKGTKLSVKPNIQNPDPAV 118 >1ZS8-A nrPDB Length = 274 Score = 33.4 bits (74), Expect = 0.34, Method: Composition-based stats. Identities = 20/84 (23%), Positives = 30/84 (35%), Gaps = 21/84 (25%) Query: 238 DAPTISPLNTSYRSGENLNLSCHAASNPPAQY--SWFVNGTFQQSTQELFIPNITVNNSG 295 DAP + G N+ L C A PA +W +G TQ++ +P+ G Sbjct: 182 DAPRTHVTHKVTPEG-NVTLRCWALGFYPADITLTWKRDGK--NHTQDMELPDTRPAGDG 238 Query: 296 S----------------YTCQAHN 303 + YTC H+ Sbjct: 239 TFQKWAAVVVPFGEELRYTCHVHH 262 >6CQN-D nrPDB Length = 205 Score = 33.4 bits (74), Expect = 0.34, Method: Composition-based stats. Identities = 21/117 (17%), Positives = 31/117 (26%), Gaps = 22/117 (18%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWV-------------------NNQSLPVS 366 S S V++ D+ TC N L W + +S Sbjct: 4 VEQSPQSLHVQEGDSTNFTCSFPSSNFYALHWYRWETAKSPEALFVMTLNGDEKKKGRIS 63 Query: 367 PRLQLSNDNRTLTLLSVTRNDVGPYEC---GIQNKLSVDHSDPVILNVLYGPDDPTI 420 L L + D Y C NKL+ V++ DP + Sbjct: 64 ATLNTKEGYSYLYIKGSQPEDSATYLCAFKAAGNKLTFGGGTRVLVKPNIQNPDPAV 120 Score = 33.4 bits (74), Expect = 0.40, Method: Composition-based stats. Identities = 24/129 (18%), Positives = 43/129 (33%), Gaps = 22/129 (17%) Query: 151 SNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLP-------------------VSPRL 191 S S V++ D+ FTC + + L W ++ +S L Sbjct: 7 SPQSLHVQEGDSTNFTCSFPSSNFYALHWYRWETAKSPEALFVMTLNGDEKKKGRISATL 66 Query: 192 QLSNGNRTLTLFNVTRNDTASYKC---ETQNPVSARRSDSVILNVLYGPDAPTISPLNTS 248 G L + D+A+Y C N ++ V++ P + L S Sbjct: 67 NTKEGYSYLYIKGSQPEDSATYLCAFKAAGNKLTFGGGTRVLVKPNIQNPDPAVYQLRDS 126 Query: 249 YRSGENLNL 257 S +++ L Sbjct: 127 KSSDKSVCL 135 >2BNR-D nrPDB Length = 203 Score = 33.4 bits (74), Expect = 0.37, Method: Composition-based stats. Identities = 20/131 (15%), Positives = 44/131 (33%), Gaps = 6/131 (4%) Query: 43 FNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIY 102 +V EG+ ++L ++ W++ + G ++ ++ T G + + Sbjct: 10 LSVPEGENLVLNCSFTDSAIYNLQWFRQDPGKGLTSLLLIQSSQREQTSGRLNASLDKSS 69 Query: 103 PNASLLIQNIIQNDTGFYTLHVIKSDLVN------EEATGQFRVYPELPKPSISSNNSKP 156 ++L I D+ Y V + + + Y + P P++ Sbjct: 70 GRSTLYIAASQPGDSATYLCAVRPTSGGSYIPTFGRGTSLIVHPYIQNPDPAVYQLRDSK 129 Query: 157 VEDKDAVAFTC 167 DK FT Sbjct: 130 SSDKSVCLFTD 140 >3KG5-A nrPDB Length = 134 Score = 33.4 bits (74), Expect = 0.37, Method: Composition-based stats. Identities = 23/103 (22%), Positives = 37/103 (35%), Gaps = 10/103 (9%) Query: 22 ASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFG-YSWYKGERVDGNRQII 80 S + NP +A I +P +A + + +H G SW + +D N Q + Sbjct: 5 RSEDRYRNPKGSACSRIWQSPRFIARKRGFTVKMHCYMNSASGNVSWLWKQEMDENPQQL 64 Query: 81 GYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLH 123 G + + + A+L IQ I D G Y Sbjct: 65 KLEKGRMEESQNES---------LATLTIQGIRFEDNGIYFCQ 98 Score = 32.2 bits (71), Expect = 0.77, Method: Composition-based stats. Identities = 13/85 (15%), Positives = 25/85 (29%), Gaps = 9/85 (10%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGN---------RTL 556 S + V C + + W + +L+L G TL Sbjct: 23 QSPRFIARKRGFTVKMHCYMNSASGNVSWLWKQEMDENPQQLKLEKGRMEESQNESLATL 82 Query: 557 TLFNVTRNDARAYVCGIQNSVSANR 581 T+ + D Y C + + ++ Sbjct: 83 TIQGIRFEDNGIYFCQQKCNNTSEV 107 >2PTT-A nrPDB Length = 110 Score = 33.4 bits (74), Expect = 0.40, Method: Composition-based stats. Identities = 8/44 (18%), Positives = 15/44 (34%) Query: 188 SPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVIL 231 R+ L N L + NV + D +Y ++ + Sbjct: 63 KGRVYLEENNGALHISNVRKEDKGTYYMRVLRETENELKITLEV 106 >1DLF-L nrPDB Length = 113 Score = 33.4 bits (74), Expect = 0.40, Method: Composition-based stats. Identities = 19/102 (18%), Positives = 26/102 (25%), Gaps = 22/102 (21%) Query: 154 SKPVEDKDAVAFTCE-----PETQDATYLWWVNNQSLPVSPRLQLSNGNR---------- 198 S PV + + +C + TYL W + L NR Sbjct: 10 SLPVSLGNQASISCRSSQSLVHSNGNTYLHWYLQKPGQSPKLLIYKVSNRFSGVPDRFSG 69 Query: 199 -------TLTLFNVTRNDTASYKCETQNPVSARRSDSVILNV 233 TL + V D Y C V L + Sbjct: 70 SGSGTDFTLKISRVEAEDLGVYFCSQSTHVPFTFGSGTKLEI 111 >4K0V-A nrPDB Length = 529 Score = 33.0 bits (73), Expect = 0.41, Method: Composition-based stats. Identities = 13/105 (12%), Positives = 30/105 (28%), Gaps = 8/105 (7%) Query: 141 YPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATY---LWWVNNQSLPVSPRLQLSNGN 197 P + + + V C+ + V + P+ + Sbjct: 323 IPRMTPKIVDLPDHIEVNSGK-FNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDH 381 Query: 198 RTLTLFNVTR---NDTASYKCETQNPVSARRSDSVILNVLYGPDA 239 ++ +F + R D+ + C N V+ ++V P Sbjct: 382 FSVAIFTIHRILPPDSGVWVCSV-NTVAGMVEKPFNISVKVLPKP 425 Score = 31.8 bits (70), Expect = 0.99, Method: Composition-based stats. Identities = 25/147 (17%), Positives = 45/147 (30%), Gaps = 23/147 (15%) Query: 259 CHAASNPPAQYS----WFVNGTFQQ----------STQELFIPNITVNNSGSYTCQAHNS 304 C A+ P +GT S I I +SG + C + Sbjct: 348 CKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTV 407 Query: 305 DTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLP 364 + + ++ V PKP N + + + ++ EP + + P Sbjct: 408 AGMVEKPFNISVKVL---PKPLNAPNVIDTGHNFAVINISSEPYFGDGP-IKSKKLLYKP 463 Query: 365 VSPRL-----QLSNDNRTLTLLSVTRN 386 V+ Q++N+ TL L Sbjct: 464 VNHYEAWQHIQVTNEIVTLNYLEPRTE 490 >5YD3-A nrPDB Length = 251 Score = 33.0 bits (73), Expect = 0.44, Method: Composition-based stats. Identities = 20/93 (21%), Positives = 31/93 (33%), Gaps = 5/93 (5%) Query: 128 DLVNEEATGQFRVYP-ELPKPSISSNNSKPVEDKDAVAF-TCEPETQDATYLWWVNNQSL 185 D+V +A V P E S S+ S + + F + Q L + + Sbjct: 139 DIVMTQAAPSVSVTPGESVSISCRSSKSLLHRNGNTYLFWFLQRPGQSPQLLIYRMSNLA 198 Query: 186 PVSPRLQLSNGNRT---LTLFNVTRNDTASYKC 215 P +G+ T L + V D Y C Sbjct: 199 SGVPDRFSGSGSGTAFTLRISRVEAEDVGVYYC 231 >6J8G-B nrPDB Length = 218 Score = 33.0 bits (73), Expect = 0.45, Method: Composition-based stats. Identities = 15/52 (28%), Positives = 20/52 (38%), Gaps = 1/52 (1%) Query: 253 ENLNLSCHAASNPPAQYSWF-VNGTFQQSTQELFIPNITVNNSGSYTCQAHN 303 EN L + W GT +FI N+T N+SG Y C + Sbjct: 74 ENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYR 125 >4L1H-A nrPDB Length = 107 Score = 33.0 bits (73), Expect = 0.45, Method: Composition-based stats. Identities = 15/89 (16%), Positives = 31/89 (34%), Gaps = 25/89 (28%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP + S G+ + ++C A+ + +W+ G Sbjct: 5 TQSPSSLSASVGDRVTITCRASQDIIKYLAWYQQKPGKAPKLLIYEASNLQAGVPSRFSG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQAHNS 304 + + L I ++ + +Y CQ + S Sbjct: 65 SGSGTDFTLTISSLQPEDFATYYCQQYQS 93 Score = 31.4 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 18/84 (21%), Positives = 26/84 (30%), Gaps = 17/84 (20%) Query: 149 ISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRL 191 S +S D V TC YL W + +P Sbjct: 5 TQSPSSLSASVGDRVTITCRASQDIIKYLAWYQQKPGKAPKLLIYEASNLQAGVPSRFSG 64 Query: 192 QLSNGNRTLTLFNVTRNDTASYKC 215 S + TLT+ ++ D A+Y C Sbjct: 65 SGSGTDFTLTISSLQPEDFATYYC 88 Score = 31.4 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 19/101 (18%), Positives = 29/101 (28%), Gaps = 17/101 (16%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQS-----------------LPVSPRLQ 548 S +S D V TC YL W + +P Sbjct: 6 QSPSSLSASVGDRVTITCRASQDIIKYLAWYQQKPGKAPKLLIYEASNLQAGVPSRFSGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDV 589 S + TLT+ ++ D Y C S+ L++ Sbjct: 66 GSGTDFTLTISSLQPEDFATYYCQQYQSLPYTFGQGTKLEI 106 Score = 30.3 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 21/104 (20%), Positives = 30/104 (28%), Gaps = 17/104 (16%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS-------LPVSPRLQLSNDNR-- 376 S +S D V +TC YL W + + + LQ +R Sbjct: 4 MTQSPSSLSASVGDRVTITCRASQDIIKYLAWYQQKPGKAPKLLIYEASNLQAGVPSRFS 63 Query: 377 --------TLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVL 412 TLT+ S+ D Y C L L + Sbjct: 64 GSGSGTDFTLTISSLQPEDFATYYCQQYQSLPYTFGQGTKLEIT 107 >5F4V-A nrPDB Length = 253 Score = 33.0 bits (73), Expect = 0.47, Method: Composition-based stats. Identities = 13/69 (18%), Positives = 23/69 (33%), Gaps = 3/69 (4%) Query: 271 WFVNGTF---QQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFI 327 W N + L P + ++GSY C+ + ++ +TV + K Sbjct: 181 WGNNTETLVSKGKEATLTKPMVGPEDAGSYRCELGSVNSSPATIINFHVTVLPKMIKEEK 240 Query: 328 TSNNSNPVE 336 S N Sbjct: 241 PSPNIVTGR 249 >2OZ4-H nrPDB Length = 214 Score = 33.0 bits (73), Expect = 0.49, Method: Composition-based stats. Identities = 18/156 (11%), Positives = 45/156 (28%), Gaps = 38/156 (24%) Query: 416 DDPTISPSYTYYRPGVNLSLSCHAASNPPAQY--SWLIDGNIQ----------------- 456 + +PG ++ +SC + +++ W+ + + Sbjct: 1 EVQLQQSGPELVQPGASVKISCKTSGYTFSEFTMHWVKQSHGKSLEWIGGINTINGGSSY 60 Query: 457 ----QHTQELFISN-----------ITEKNSGLYTCQANNSASGHSRTTVKTITVSAELP 501 + L + +T ++S +Y C A + + T+ T++ + P Sbjct: 61 KQSFKDKATLTVDKSSSTAYMELNSLTSEDSAVYYC-ATKGFAYWGQGTLVTVSAAKTTP 119 Query: 502 KPSISSNNSKPVEDKDAVAFTCEPEA---QNTTYLW 534 + V C + + T W Sbjct: 120 PSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTW 155 >4PFE-A nrPDB Length = 345 Score = 32.6 bits (72), Expect = 0.63, Method: Composition-based stats. Identities = 12/87 (13%), Positives = 27/87 (31%), Gaps = 5/87 (5%) Query: 43 FNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIY 102 + P + + WY+ + G +++ + GR I Sbjct: 241 VQPGGSLRLSCAASGFPVNRYSMRWYRQAPGKEREWVAGMSSAGDRSSYEDSVKGRFTIS 300 Query: 103 PNAS-----LLIQNIIQNDTGFYTLHV 124 + + L + ++ DT Y +V Sbjct: 301 RDDARNTVYLQMNSLKPEDTAVYYCNV 327 >5XCQ-B nrPDB Length = 164 Score = 32.2 bits (71), Expect = 0.71, Method: Composition-based stats. Identities = 14/45 (31%), Positives = 19/45 (42%), Gaps = 3/45 (6%) Query: 81 GYVIGTQQATPG--PAYSGREIIYPNASLLIQNIIQNDTGFYTLH 123 G ++GT PG P +SG +I A+L I D Y Sbjct: 51 GLIVGTNNRVPGVPPRFSGS-LIEDKAALTITGAQTEDEAIYFCA 94 Score = 31.8 bits (70), Expect = 0.97, Method: Composition-based stats. Identities = 11/92 (11%), Positives = 22/92 (23%), Gaps = 28/92 (30%) Query: 243 SPLNTSYRSGENLNLSCHAA----------------------------SNPPAQYSWFVN 274 + GE + L+C ++ +N + Sbjct: 9 QESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIVGTNNRVPGVPPRFS 68 Query: 275 GTFQQSTQELFIPNITVNNSGSYTCQAHNSDT 306 G+ + L I + Y C S+ Sbjct: 69 GSLIEDKAALTITGAQTEDEAIYFCALWYSNH 100 Score = 31.4 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 16/91 (17%), Positives = 25/91 (27%), Gaps = 20/91 (21%) Query: 145 PKPSISSNNSKPVEDKDAVAFTCEPETQDAT---YLWWVNNQS----------------- 184 + ++ ++ + V TC T T Y WV + Sbjct: 3 TQTVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIVGTNNRVPG 62 Query: 185 LPVSPRLQLSNGNRTLTLFNVTRNDTASYKC 215 +P L LT+ D A Y C Sbjct: 63 VPPRFSGSLIEDKAALTITGAQTEDEAIYFC 93 >6J8E-C nrPDB Length = 122 Score = 32.2 bits (71), Expect = 0.73, Method: Composition-based stats. Identities = 11/38 (28%), Positives = 14/38 (36%) Query: 193 LSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVI 230 S + ++ L NV D Y C NP R I Sbjct: 79 PSKYDVSVMLRNVQPEDEGIYNCYIMNPPDRHRGHGKI 116 Score = 30.3 bits (66), Expect = 2.9, Method: Composition-based stats. Identities = 7/31 (22%), Positives = 16/31 (51%) Query: 629 INGIPQQHTQVLFIAKITPNNNGTYACFVSN 659 +G P ++ + + + P + G Y C++ N Sbjct: 75 FSGNPSKYDVSVMLRNVQPEDEGIYNCYIMN 105 >4PD4-K nrPDB Length = 107 Score = 32.2 bits (71), Expect = 0.76, Method: Composition-based stats. Identities = 14/58 (24%), Positives = 24/58 (41%), Gaps = 2/58 (3%) Query: 66 SWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLH 123 +WY+ ++ DG +++ Y A +SG + SL I N+ D Y Sbjct: 34 NWYQ-QKPDGTIKLLIYYTSRLHAGVPSRFSGSGSGT-DYSLTISNLEPEDIATYFCQ 89 Score = 32.2 bits (71), Expect = 0.86, Method: Composition-based stats. Identities = 15/85 (17%), Positives = 32/85 (37%), Gaps = 25/85 (29%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFV---NGTFQ------------------- 278 T +P++ + G+ + +SC A+ + +W+ +GT + Sbjct: 5 TQTPVSLAASLGDRVTISCRASQDINNFLNWYQQKPDGTIKLLIYYTSRLHAGVPSRFSG 64 Query: 279 ---QSTQELFIPNITVNNSGSYTCQ 300 + L I N+ + +Y CQ Sbjct: 65 SGSGTDYSLTISNLEPEDIATYFCQ 89 >1A14-L nrPDB Length = 104 Score = 32.2 bits (71), Expect = 0.78, Method: Composition-based stats. Identities = 18/88 (20%), Positives = 33/88 (37%), Gaps = 6/88 (6%) Query: 37 TIESTPFNVAEGKEVLLLVHNLPQHLFGY-SWYKGERVDGNRQIIGYVIGTQQATPGPAY 95 T S ++ + + Q + Y +WY+ + DG +++ Y + + Sbjct: 7 TTSSLSASLGDRVTISCRAS---QDISNYLNWYQ-QNPDGTVKLLIYYTSNLHSEVPSRF 62 Query: 96 SGREIIYPNASLLIQNIIQNDTGFYTLH 123 SG + SL I N+ Q D Y Sbjct: 63 SGSGSGT-DYSLTISNLEQEDIATYFCQ 89 Score = 31.4 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 19/86 (22%), Positives = 30/86 (34%), Gaps = 17/86 (19%) Query: 147 PSISSNNSKPVEDKDAVAFTCEPETQDATYL-WWVNNQSLPVS-------------PRLQ 192 + +S D V +C + YL W+ N V P Sbjct: 3 ELTQTTSSLSASLGDRVTISCRASQDISNYLNWYQQNPDGTVKLLIYYTSNLHSEVPSRF 62 Query: 193 LSNGNRT---LTLFNVTRNDTASYKC 215 +G+ T LT+ N+ + D A+Y C Sbjct: 63 SGSGSGTDYSLTISNLEQEDIATYFC 88 Score = 31.1 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 14/84 (16%), Positives = 25/84 (29%), Gaps = 17/84 (20%) Query: 506 SSNNSKPVEDKDAVAFTCEPEAQNTTY-LWWVNG----------------QSLPVSPRLQ 548 + +S D V +C + Y W+ +P Sbjct: 6 QTTSSLSASLGDRVTISCRASQDISNYLNWYQQNPDGTVKLLIYYTSNLHSEVPSRFSGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCG 572 S + +LT+ N+ + D Y C Sbjct: 66 GSGTDYSLTISNLEQEDIATYFCQ 89 Score = 30.3 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 15/96 (15%), Positives = 29/96 (30%), Gaps = 19/96 (19%) Query: 325 PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLP--------------VSPRLQ 370 + +S D V ++C + YL W P Sbjct: 3 ELTQTTSSLSASLGDRVTISCRASQDISNYLNWYQQNPDGTVKLLIYYTSNLHSEVPSRF 62 Query: 371 LSNDNRT---LTLLSVTRNDVGPYECGIQNKLSVDH 403 + + T LT+ ++ + D+ Y C Q ++ Sbjct: 63 SGSGSGTDYSLTISNLEQEDIATYFC--QQDFTLPF 96 >1XAU-A nrPDB Length = 122 Score = 32.2 bits (71), Expect = 0.79, Method: Composition-based stats. Identities = 16/62 (25%), Positives = 22/62 (35%), Gaps = 10/62 (16%) Query: 172 QDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVIL 231 Y W N+S+PV L + +D SY C T S SV + Sbjct: 63 GPQLYTSWEENRSVPV----------FVLHFKPIHLSDNGSYSCSTNFNSQVINSHSVTI 112 Query: 232 NV 233 +V Sbjct: 113 HV 114 >4KKN-A nrPDB Length = 133 Score = 32.2 bits (71), Expect = 0.83, Method: Composition-based stats. Identities = 11/61 (18%), Positives = 21/61 (34%), Gaps = 4/61 (6%) Query: 158 EDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCET 217 E V C L ++++ + + R LT+ + DT Y C+ Sbjct: 46 EAGSQVTEVCAGTYMVEDELTFLDDSTCIGTSR----GNKVNLTIQGLRAMDTGLYVCKV 101 Query: 218 Q 218 + Sbjct: 102 E 102 >1BFV-L nrPDB Length = 113 Score = 32.2 bits (71), Expect = 0.88, Method: Composition-based stats. Identities = 19/102 (18%), Positives = 26/102 (25%), Gaps = 22/102 (21%) Query: 154 SKPVEDKDAVAFTCE-----PETQDATYLWWVNNQSLPVSPRLQLSNGNR---------- 198 S PV D V+ +C YL W + + NR Sbjct: 10 SLPVSLGDQVSISCRSSQSLVSNNRRNYLHWYLQKPGQSPKLVIYKVSNRFSGVPDRFSG 69 Query: 199 -------TLTLFNVTRNDTASYKCETQNPVSARRSDSVILNV 233 TL + V D Y C + V L + Sbjct: 70 SGSGTDFTLKISRVAAEDLGLYFCSQSSHVPLTFGSGTKLEI 111 >3UPA-A nrPDB Length = 107 Score = 31.8 bits (70), Expect = 0.91, Method: Composition-based stats. Identities = 15/89 (16%), Positives = 31/89 (34%), Gaps = 25/89 (28%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP + S G+ + ++C A+ + + +W+ G Sbjct: 5 TQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYDADDLQSGVPSRFSG 64 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQAHNS 304 + + L I ++ + +Y CQ S Sbjct: 65 SGSGTDFTLTISSLQPEDFATYYCQQSYS 93 Score = 31.4 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 18/102 (17%), Positives = 31/102 (30%), Gaps = 17/102 (16%) Query: 149 ISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQS-----------------LPVSPRL 191 S +S D V TC ++YL W + +P Sbjct: 5 TQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYDADDLQSGVPSRFSG 64 Query: 192 QLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNV 233 S + TLT+ ++ D A+Y C+ + + Sbjct: 65 SGSGTDFTLTISSLQPEDFATYYCQQSYSTPNTFGQGTKVEI 106 Score = 31.4 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 15/84 (17%), Positives = 23/84 (27%), Gaps = 17/84 (20%) Query: 506 SSNNSKPVEDKDAVAFTCEP--------------EAQNTTYLWWVNGQ---SLPVSPRLQ 548 S +S D V TC + L + +P Sbjct: 6 QSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYDADDLQSGVPSRFSGS 65 Query: 549 LSNGNRTLTLFNVTRNDARAYVCG 572 S + TLT+ ++ D Y C Sbjct: 66 GSGTDFTLTISSLQPEDFATYYCQ 89 Score = 31.1 bits (68), Expect = 1.9, Method: Composition-based stats. Identities = 18/85 (21%), Positives = 26/85 (30%), Gaps = 17/85 (20%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNR--------- 376 S +S D V +TC ++YL W + L D+ Sbjct: 4 MTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYDADDLQSGVPSRFS 63 Query: 377 --------TLTLLSVTRNDVGPYEC 393 TLT+ S+ D Y C Sbjct: 64 GSGSGTDFTLTISSLQPEDFATYYC 88 >4I18-R nrPDB Length = 211 Score = 31.8 bits (70), Expect = 0.94, Method: Composition-based stats. Identities = 19/127 (14%), Positives = 31/127 (24%), Gaps = 19/127 (14%) Query: 337 DEDAVALTCEPEIQNTTYLWWV--NNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYEC- 393 C + T WW + LP + L + TL GP C Sbjct: 4 PGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCH 63 Query: 394 ----------------GIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSC 437 N++ SD + ++V Y + + Sbjct: 64 FGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYL 123 Query: 438 HAASNPP 444 +PP Sbjct: 124 WIKWSPP 130 >2X44-D nrPDB Length = 131 Score = 31.8 bits (70), Expect = 0.95, Method: Composition-based stats. Identities = 18/96 (18%), Positives = 31/96 (32%), Gaps = 21/96 (21%) Query: 567 RAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLS----CHSASNPS 622 ++VC S ++ V + VL D+ + ++Y+ G L C Sbjct: 20 ASFVCE---YASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICT------ 70 Query: 623 PQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVS 658 G + L I + + G Y C V Sbjct: 71 --------GTSSGNQVNLTIQGLRAMDTGLYICKVE 98 >2G2R-H nrPDB Length = 219 Score = 31.8 bits (70), Expect = 0.95, Method: Composition-based stats. Identities = 18/85 (21%), Positives = 33/85 (38%), Gaps = 7/85 (8%) Query: 194 SNGNRTLTLFNVTRNDTASYKCETQNPVSARR--SDSVILNVLYGP-DAPTISPLNTSYR 250 S+ + L ++T D+A Y C + + R ++ V AP++ PL Sbjct: 75 SSNTAYMDLNSLTSEDSAVYYCVPYDYAADRVYWGHGTLVTVSTAKTTAPSVYPLAPVCG 134 Query: 251 --SGENLNLSCHAASN-PPA-QYSW 271 +G ++ L C P +W Sbjct: 135 GTTGSSVTLGCLVKGYFPEPVTLTW 159 >3FG7-A nrPDB Length = 398 Score = 31.8 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 25/153 (16%), Positives = 38/153 (24%), Gaps = 22/153 (14%) Query: 517 DAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLT--LFNVTRNDARAYVCGIQ 574 E Q W G P + +L N +T LF + R I Sbjct: 242 SRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQEENLVITPRLFECSNKTGRFLATEIP 301 Query: 575 --NSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLN----LSCHSASN-------- 620 N D LDV I + A L H + Sbjct: 302 DFNQDDLEEDDVFLLDVWDQVFFWIGKHANEEEKKAAATTAQEYLKTHPSGRDPETPIIV 361 Query: 621 ------PSPQYSWRINGIPQQHTQVLFIAKITP 647 P W + P + + + + ++P Sbjct: 362 VKQGHEPPTFTGWFLAWDPFKWSGIHVVPNLSP 394 >5C09-D nrPDB Length = 200 Score = 31.8 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 18/119 (15%), Positives = 36/119 (30%), Gaps = 18/119 (15%) Query: 154 SKPVEDKDAVAFTCEPETQDATYLWWV------------------NNQSLPVSPRLQLSN 195 V + V+ C Y W N + + ++ S+ Sbjct: 8 PLSVPEGAIVSLNCTYSNSAFQYFMWYRQYSRKGPELLMYTYSSGNKEDGRFTAQVDKSS 67 Query: 196 GNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGEN 254 +L + + +D+A+Y C + S + +L PD P R ++ Sbjct: 68 KYISLFIRDSQPSDSATYLCAMRGDSSYKLIFGSGTRLLVRPDIQNPDPAVYQLRDSKS 126 >3U0W-H nrPDB Length = 216 Score = 31.4 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 20/76 (26%), Positives = 26/76 (34%), Gaps = 4/76 (5%) Query: 199 TLTLFNVTRNDTASYKCETQ-NPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNL 257 L + V DTA Y C Q + +V GP ++P + S SG L Sbjct: 80 YLQMSKVRSEDTAIYYCARQMGYWGQGTTLTVSSASTKGPSVFPLAPSSKST-SGGTAAL 138 Query: 258 SCHAASN-PPA-QYSW 271 C P SW Sbjct: 139 GCLVKDYFPEPVTVSW 154 >2FB4-L nrPDB Length = 216 Score = 31.4 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 26/140 (18%), Positives = 45/140 (32%), Gaps = 24/140 (17%) Query: 200 LTLFNVTRNDTASYKCETQNPVSAR--RSDSVILNVLYGPDA-PTI--SPLNTSYRSGEN 254 L + + D Y C + + VL P A PT+ P ++ Sbjct: 74 LAIGGLQSEDETDYYCAAWDVSLNAYVFGTGTKVTVLGQPKANPTVTLFPPSSEELQANK 133 Query: 255 LNLSCHAASNPPA--QYSWFVNGTFQQSTQELFIPNITVNNS-----------------G 295 L C + P +W +G+ ++ E P+ NN Sbjct: 134 ATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHR 193 Query: 296 SYTCQAHNSDTGLNRTTVTT 315 SY+CQ + + + +T T Sbjct: 194 SYSCQVTHEGSTVEKTVAPT 213 >1JFQ-H nrPDB Length = 222 Score = 31.4 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 18/106 (16%), Positives = 30/106 (28%), Gaps = 10/106 (9%) Query: 176 YLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPV--SARRSDSVILNV 233 Y+ + + + S+ + L ++T D+A Y C S + Sbjct: 57 YITYNEKFKGKTTLTVDKSSNTAYMQLRSLTSEDSAVYFCARSEYYGGSYKFDYWGQGTT 116 Query: 234 LYGPDAPTISPLNTSYRSGEN------LNLSCHAASN-PPA-QYSW 271 L A T P G + L C P +W Sbjct: 117 LTVSSAGTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTW 162 >5XP1-A nrPDB Length = 109 Score = 31.1 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 14/89 (15%), Positives = 30/89 (33%), Gaps = 25/89 (28%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVN-------------------------G 275 T SP + S G+ + ++C A+ + +W+ G Sbjct: 6 TQSPSSLSASVGDRVTITCQASQDIIKYLNWYQQTPGKAPKLLIYEASNLQAGVPSRFSG 65 Query: 276 TFQQSTQELFIPNITVNNSGSYTCQAHNS 304 + + I ++ + +Y CQ + S Sbjct: 66 SGSGTDYTFTISSLQPEDIATYYCQQYQS 94 Score = 30.3 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 20/104 (19%), Positives = 30/104 (28%), Gaps = 17/104 (16%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS-------LPVSPRLQLSNDNR-- 376 S +S D V +TC+ YL W + + LQ +R Sbjct: 5 MTQSPSSLSASVGDRVTITCQASQDIIKYLNWYQQTPGKAPKLLIYEASNLQAGVPSRFS 64 Query: 377 --------TLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVL 412 T T+ S+ D+ Y C L L + Sbjct: 65 GSGSGTDYTFTISSLQPEDIATYYCQQYQSLPKTFGQGTKLQIT 108 >4N8P-A nrPDB Length = 135 Score = 30.7 bits (67), Expect = 2.1, Method: Composition-based stats. Identities = 11/32 (34%), Positives = 15/32 (46%) Query: 187 VSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ 218 + +Q S N TLTL + DT Y C + Sbjct: 73 IECHVQPSENNVTLTLMGLKATDTGLYVCRVE 104 Score = 30.3 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 11/28 (39%), Positives = 15/28 (53%) Query: 547 LQLSNGNRTLTLFNVTRNDARAYVCGIQ 574 +Q S N TLTL + D YVC ++ Sbjct: 77 VQPSENNVTLTLMGLKATDTGLYVCRVE 104 >1AO7-D nrPDB Length = 204 Score = 30.7 bits (67), Expect = 2.5, Method: Composition-based stats. Identities = 13/121 (10%), Positives = 32/121 (26%), Gaps = 18/121 (14%) Query: 152 NNSKPVEDKDAVAFTCEPE-TQDATYLWWVNNQSLPVSPRLQLSNGNR------------ 198 + V + + C ++ W+ + + + Sbjct: 7 SGPLSVPEGAIASLNCTYSDRGSQSFFWYRQYSGKSPELIMSIYSNGDKEDGRFTAQLNK 66 Query: 199 -----TLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGE 253 +L + + +D+A+Y C + V+ PD P R + Sbjct: 67 ASQYVSLLIRDSQPSDSATYLCAVTTDSWGKLQFGAGTQVVVTPDIQNPDPAVYQLRDSK 126 Query: 254 N 254 + Sbjct: 127 S 127 >4WW2-A nrPDB Length = 207 Score = 30.7 bits (67), Expect = 2.6, Method: Composition-based stats. Identities = 21/127 (16%), Positives = 38/127 (29%), Gaps = 19/127 (14%) Query: 147 PSISSNNSKPVEDKDAVAFTC---------------EPETQDATYLWWVNNQSLPVSPRL 191 + V + + + C +P + L ++Q S RL Sbjct: 4 EVTQIPAALSVPEGENLVLNCSFTDSAIYNLQWFRQDPGKGLTSLLLIQSSQREQTSGRL 63 Query: 192 QLS----NGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNT 247 S +G TL + D+A+Y C N + +L P+ P Sbjct: 64 NASLDKSSGRSTLYIAASQPGDSATYLCAGVNTGFQKLVFGTGTRLLVSPNIQNPDPAVY 123 Query: 248 SYRSGEN 254 R ++ Sbjct: 124 QLRDSKS 130 >4Q58-C nrPDB Length = 195 Score = 30.3 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 19/125 (15%), Positives = 39/125 (31%), Gaps = 12/125 (9%) Query: 117 TGFYTLHV---IKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQD 173 G Y+ V ++ +E F V + ++ + A D Sbjct: 79 EGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDD 138 Query: 174 ATYLWWVNNQSLPVSPRLQLSN-GNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILN 232 N+ + ++ + N NR L + N+ + Y + +N I+N Sbjct: 139 --------NRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIIN 190 Query: 233 VLYGP 237 + P Sbjct: 191 LATQP 195 >6DKP-D nrPDB Length = 200 Score = 30.3 bits (66), Expect = 3.1, Method: Composition-based stats. Identities = 23/132 (17%), Positives = 42/132 (31%), Gaps = 6/132 (4%) Query: 40 STPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGRE 99 S P +V EG L + + WY+ + G + I + ++ + Sbjct: 8 SGPLSVPEGAIASLNCTYSYRGSQSFFWYR--QYSGKSPELIMFIASNGDKEDGRFTAQL 65 Query: 100 IIYPN-ASLLIQNIIQNDTGFYTLHVIKSDLV---NEEATGQFRVYPELPKPSISSNNSK 155 SLLI++ +D+ Y V + + + P P++ Sbjct: 66 NKASQYVSLLIRDSQPSDSATYLCAVNFGGGKLIFGQGTELSVKPNIQNPDPAVYQLRDS 125 Query: 156 PVEDKDAVAFTC 167 DK FT Sbjct: 126 KSSDKSVCLFTD 137 >1PEW-A nrPDB Length = 109 Score = 30.3 bits (66), Expect = 3.1, Method: Composition-based stats. Identities = 18/108 (16%), Positives = 35/108 (32%), Gaps = 19/108 (17%) Query: 324 KPFITSNNSNPVEDEDAVALTCEPEIQNTT--YLWWVNNQSLPV---------------- 365 + +S V ++C N Y+ W +S P+ Sbjct: 1 NFMLNQPHSVSESPGKTVTISCTRSSGNIASNYVQWYQQRSAPITVIYEDNQRPSGVPDR 60 Query: 366 -SPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVL 412 + + S+++ +LT+ + D Y C + +V L VL Sbjct: 61 FAGSIDRSSNSASLTISGLKTEDEADYYCQSYDARNVVFGGGTRLTVL 108 Score = 29.1 bits (63), Expect = 6.2, Method: Composition-based stats. Identities = 16/84 (19%), Positives = 31/84 (36%), Gaps = 22/84 (26%) Query: 160 KDAVAFTCEPETQD--ATYLWWVNNQSLPVS------------PRLQL-----SNGNRTL 200 V +C + + + Y+ W +S P++ P S+ + +L Sbjct: 15 GKTVTISCTRSSGNIASNYVQWYQQRSAPITVIYEDNQRPSGVPDRFAGSIDRSSNSASL 74 Query: 201 TLFNVTRNDTASYKCE---TQNPV 221 T+ + D A Y C+ +N V Sbjct: 75 TISGLKTEDEADYYCQSYDARNVV 98 >2Q20-A nrPDB Length = 109 Score = 29.9 bits (65), Expect = 3.6, Method: Composition-based stats. Identities = 20/103 (19%), Positives = 30/103 (29%), Gaps = 17/103 (16%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS---------------LPVSPRLQ 370 S +S D V +TC+ + YL W + V R Sbjct: 6 MTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFS 65 Query: 371 LSNDNR--TLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNV 411 S T T+ S+ D+ Y C + L L + Sbjct: 66 GSGSGTDFTFTISSLQPEDIATYYCQQYDNLPYTFGQGTKLEI 108 >2EDO-A nrPDB Length = 121 Score = 29.9 bits (65), Expect = 4.3, Method: Composition-based stats. Identities = 11/55 (20%), Positives = 20/55 (36%) Query: 188 SPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTI 242 R++L + L + V + D ++Y + + L VL P I Sbjct: 63 KGRVRLDPQSGALYISKVQKEDNSTYIMRVLKKTGNEQEWKIKLQVLDPVPKPVI 117 >3AB0-C nrPDB Length = 106 Score = 29.5 bits (64), Expect = 4.5, Method: Composition-based stats. Identities = 18/89 (20%), Positives = 32/89 (35%), Gaps = 26/89 (29%) Query: 241 TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGT------FQQSTQ------------ 282 T SP S GE + +SC A S+ + W+ + + T Sbjct: 6 TQSPAIMSASPGEKVTISCSARSS-VSYMYWYQQKSGSSPKPWIYRTSNLASGVPARFSG 64 Query: 283 -------ELFIPNITVNNSGSYTCQAHNS 304 L I ++ ++ +Y CQ ++S Sbjct: 65 SGSGTSYSLTISSMEAEDAATYYCQQYHS 93 >1WTL-A nrPDB Length = 108 Score = 29.5 bits (64), Expect = 5.3, Method: Composition-based stats. Identities = 19/103 (18%), Positives = 31/103 (30%), Gaps = 17/103 (16%) Query: 326 FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQS---------------LPVSPRLQ 370 S +S D V +TC T Y+ W + V R Sbjct: 4 MTQSPSSLSASVGDRVTITCRASQDITNYVNWFQQRPGQAPKVLIYGASILETGVPSRFS 63 Query: 371 LSNDNR--TLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNV 411 S T T+ S+ D+ Y C + L + +++ Sbjct: 64 GSGSGTDFTFTISSLQPEDIATYYCQQYDTLPLTFGGGTKVDI 106 >3TYG-L nrPDB Length = 211 Score = 28.8 bits (62), Expect = 8.9, Method: Composition-based stats. Identities = 28/168 (16%), Positives = 46/168 (27%), Gaps = 18/168 (10%) Query: 66 SWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTL--- 122 SWY+ + +I V P +SG + ASL + + +D Y Sbjct: 31 SWYQQHAGKAPKLVIYDVNKRPSGVPD-RFSGSKSGN-TASLTVSGLQTDDEAVYYCGSL 88 Query: 123 ----HVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLW 178 VI GQ + P + S+ V + T W Sbjct: 89 VGNWDVIFGGGTKLTVLGQPKAAPSVTL-FPPSSEELQANKATLVCLISDFYPGAVTVAW 147 Query: 179 WVNNQSL--------PVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ 218 ++ + P + L+L SY C+ Sbjct: 148 KADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVT 195 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.304 0.112 0.291 Lambda K H 0.267 0.0343 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 22,423,366 Number of Sequences: 36641 Number of extensions: 826676 Number of successful extensions: 4394 Number of sequences better than 10.0: 241 Number of HSP's better than 10.0 without gapping: 139 Number of HSP's successfully gapped in prelim test: 168 Number of HSP's that attempted gapping in prelim test: 2050 Number of HSP's gapped (non-prelim): 1447 length of query: 702 length of database: 10,336,785 effective HSP length: 104 effective length of query: 598 effective length of database: 6,526,121 effective search space: 3902620358 effective search space used: 3902620358 T: 11 A: 40 X1: 16 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.6 bits) S2: 62 (28.7 bits)