BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P06493 (297 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6GU6-A nrPDB 611 e-175 2BPM-A nrPDB 405 e-114 3NIZ-A nrPDB 360 e-100 1V0B-A nrPDB 355 2e-98 4AU8-A nrPDB 335 2e-92 3GC0-A nrPDB 327 3e-90 5G6V-A nrPDB 323 5e-89 4KRC-A nrPDB 305 1e-83 1G3N-A nrPDB 264 3e-71 1UA2-A nrPDB 256 6e-69 2W96-B nrPDB 245 2e-65 5EFQ-A nrPDB 236 1e-62 4NST-A nrPDB 233 1e-61 4AGU-A nrPDB 229 1e-60 4BBM-A nrPDB 228 2e-60 3MIA-A nrPDB 226 8e-60 4BGQ-A nrPDB 210 5e-55 3ZDU-A nrPDB 204 4e-53 5Z33-A nrPDB 196 7e-51 2F9G-A nrPDB 194 4e-50 4CRL-A nrPDB 194 4e-50 1CM8-A nrPDB 192 2e-49 4ZSG-A nrPDB 192 2e-49 4IC8-A nrPDB 191 3e-49 6DTL-A nrPDB 189 2e-48 3OZ6-A nrPDB 187 5e-48 4QTB-A nrPDB 185 2e-47 5NGU-A nrPDB 183 9e-47 4O2Z-A nrPDB 179 1e-45 4MYG-A nrPDB 178 3e-45 4EWQ-A nrPDB 176 1e-44 3OHT-A nrPDB 175 2e-44 3FI2-A nrPDB 174 6e-44 1JNK-A nrPDB 173 7e-44 3GC9-A nrPDB 171 2e-43 4QNY-A nrPDB 166 1e-41 4E7W-A nrPDB 165 2e-41 3E7O-A nrPDB 164 4e-41 3E3P-A nrPDB 161 3e-40 3RP9-A nrPDB 160 5e-40 3N9X-A nrPDB 160 6e-40 2XS0-A nrPDB 157 4e-39 3EB0-A nrPDB 156 1e-38 3PG1-A nrPDB 153 7e-38 5AWM-A nrPDB 153 7e-38 3NIE-A nrPDB 153 7e-38 5AIR-A nrPDB 152 1e-37 2I6L-A nrPDB 141 3e-34 4MVF-A nrPDB 139 1e-33 3NCG-A nrPDB 135 3e-32 3DFA-A nrPDB 135 3e-32 5YKS-A nrPDB 133 1e-31 5XVU-A nrPDB 130 9e-31 3LIJ-A nrPDB 129 1e-30 3MA6-A nrPDB 128 2e-30 5JN2-A nrPDB 128 3e-30 5ZTN-A nrPDB 128 3e-30 6O6Q-A nrPDB 127 4e-30 4UZD-A nrPDB 125 3e-29 6EII-A nrPDB 123 9e-29 4MD7-E nrPDB 123 1e-28 3TAC-A nrPDB 123 1e-28 5Y86-A nrPDB 122 1e-28 3Q5I-A nrPDB 121 3e-28 3DXN-A nrPDB 121 4e-28 3HZT-A nrPDB 120 6e-28 3MN3-A nrPDB 120 6e-28 2PVN-A nrPDB 119 1e-27 5U6Y-A nrPDB 119 1e-27 2VZ6-A nrPDB 119 1e-27 3D2K-A nrPDB 119 1e-27 2VN9-A nrPDB 119 2e-27 3KK8-A nrPDB 119 2e-27 6HMD-A nrPDB 119 2e-27 2XNP-A nrPDB 119 2e-27 2BDW-A nrPDB 119 2e-27 6FD3-A nrPDB 118 3e-27 4D28-A nrPDB 118 3e-27 3BHH-A nrPDB 118 3e-27 2V7O-A nrPDB 118 4e-27 3SOA-A nrPDB 117 4e-27 6CQF-A nrPDB 117 5e-27 4RGJ-A nrPDB 116 1e-26 4LFI-A nrPDB 116 1e-26 4APC-A nrPDB 116 1e-26 5J5T-A nrPDB 115 2e-26 4B8L-A nrPDB 115 2e-26 3Q53-A nrPDB 115 2e-26 5IG1-A nrPDB 115 3e-26 4YNZ-A nrPDB 115 3e-26 3COM-A nrPDB 114 6e-26 2QNJ-A nrPDB 114 6e-26 6FDY-U nrPDB 113 8e-26 3H4J-B nrPDB 113 1e-25 5ES1-A nrPDB 113 1e-25 4FG9-A nrPDB 113 1e-25 5FG8-A nrPDB 112 1e-25 2BRG-A nrPDB 112 2e-25 4QMW-A nrPDB 112 2e-25 4CZT-A nrPDB 111 3e-25 2Y7J-A nrPDB 111 3e-25 2WO6-A nrPDB 111 4e-25 4WNO-A nrPDB 111 5e-25 2WQN-A nrPDB 110 6e-25 2J90-A nrPDB 110 7e-25 2YCR-A nrPDB 110 9e-25 5KZ7-A nrPDB 110 1e-24 6QAU-A nrPDB 110 1e-24 5XZW-A nrPDB 110 1e-24 4EQM-A nrPDB 109 1e-24 4YZB-A nrPDB 109 1e-24 4LG4-A nrPDB 109 2e-24 3I6U-A nrPDB 108 2e-24 5WAX-A nrPDB 108 2e-24 6AO5-A nrPDB 108 2e-24 3GUB-A nrPDB 108 2e-24 4CQG-A nrPDB 108 3e-24 4RED-A nrPDB 108 3e-24 2YAB-A nrPDB 108 3e-24 2HAK-A nrPDB 108 3e-24 6HXF-B nrPDB 108 4e-24 2JC6-A nrPDB 108 4e-24 2XIK-A nrPDB 108 4e-24 4JXF-A nrPDB 107 5e-24 4D2V-A nrPDB 107 5e-24 1ZWS-A nrPDB 107 7e-24 1U5R-A nrPDB 107 8e-24 2W4O-A nrPDB 107 8e-24 4REW-A nrPDB 107 9e-24 2A27-A nrPDB 107 9e-24 2GCD-A nrPDB 106 9e-24 4KS7-A nrPDB 106 1e-23 6C9D-A nrPDB 106 1e-23 4CFH-A nrPDB 106 1e-23 5F9E-A nrPDB 105 2e-23 5JZN-A nrPDB 103 7e-23 5D7A-A nrPDB 103 1e-22 4PDS-A nrPDB 103 1e-22 2JAM-A nrPDB 102 2e-22 4FZF-B nrPDB 102 2e-22 2WTK-C nrPDB 102 2e-22 2UV2-A nrPDB 102 2e-22 5EZV-A nrPDB 101 3e-22 2F57-A nrPDB 101 3e-22 4NIF-A nrPDB 101 3e-22 4CFF-A nrPDB 101 3e-22 5DYK-A nrPDB 101 4e-22 4AF3-A nrPDB 101 4e-22 2YZA-A nrPDB 100 6e-22 4XBR-A nrPDB 100 7e-22 4RLP-A nrPDB 100 7e-22 1PHK-A nrPDB 100 8e-22 2Q0N-A nrPDB 100 8e-22 3IS5-A nrPDB 100 9e-22 4L42-A nrPDB 100 9e-22 4AN9-A nrPDB 100 1e-21 3UDB-A nrPDB 100 1e-21 2X4F-A nrPDB 100 1e-21 3ZUT-A nrPDB 100 1e-21 4JDH-A nrPDB 100 1e-21 3UTO-A nrPDB 99 2e-21 4FIE-A nrPDB 99 2e-21 1KOA-A nrPDB 99 2e-21 4JG6-A nrPDB 99 2e-21 3DAK-A nrPDB 98 4e-21 5KKR-C nrPDB 98 5e-21 6CMJ-A nrPDB 97 6e-21 3EQC-A nrPDB 97 7e-21 5FET-A nrPDB 97 9e-21 5X8I-B nrPDB 97 1e-20 4UYA-A nrPDB 96 2e-20 1KOB-A nrPDB 96 2e-20 3PPZ-A nrPDB 95 3e-20 3TXO-A nrPDB 95 4e-20 1S9I-A nrPDB 94 5e-20 4CSV-A nrPDB 94 6e-20 2W1I-A nrPDB 94 6e-20 3IO7-A nrPDB 94 7e-20 5DBX-A nrPDB 94 7e-20 3UC3-A nrPDB 94 9e-20 5LOH-A nrPDB 94 1e-19 5X3F-B nrPDB 93 1e-19 3F3Z-A nrPDB 93 1e-19 4WB7-A nrPDB 93 1e-19 4IAN-A nrPDB 93 1e-19 6DBN-A nrPDB 93 1e-19 3QA8-A nrPDB 93 1e-19 2A1A-B nrPDB 93 2e-19 5N23-A nrPDB 92 2e-19 4U41-A nrPDB 92 2e-19 5HVK-A nrPDB 92 3e-19 6E2O-A nrPDB 92 3e-19 4GS6-A nrPDB 91 4e-19 4M7I-A nrPDB 91 5e-19 3ALO-A nrPDB 91 6e-19 4TPT-A nrPDB 91 8e-19 5YV8-A nrPDB 91 8e-19 4E93-A nrPDB 90 1e-18 3UIU-A nrPDB 90 1e-18 3KN6-A nrPDB 90 1e-18 6NPU-A nrPDB 90 1e-18 5TQX-A nrPDB 90 1e-18 3VN9-A nrPDB 89 2e-18 5UNP-A nrPDB 89 2e-18 4XEY-B nrPDB 89 2e-18 2HW6-A nrPDB 89 2e-18 4KIK-B nrPDB 89 2e-18 2JDO-A nrPDB 89 3e-18 6FYV-A nrPDB 89 3e-18 6ED6-A nrPDB 89 3e-18 2Z7Q-A nrPDB 89 3e-18 5VD3-A nrPDB 89 3e-18 6CKI-A nrPDB 88 3e-18 2FO0-A nrPDB 88 4e-18 3LM0-A nrPDB 88 5e-18 1TKI-A nrPDB 88 5e-18 5UIU-A nrPDB 87 9e-18 1ZXE-A nrPDB 87 1e-17 4RA4-A nrPDB 86 1e-17 3FME-A nrPDB 86 1e-17 6E9W-A nrPDB 86 1e-17 4C0T-A nrPDB 86 2e-17 5D9K-A nrPDB 85 4e-17 3ORZ-A nrPDB 85 5e-17 5VO2-A nrPDB 85 5e-17 3GQL-A nrPDB 84 5e-17 3RAW-A nrPDB 84 5e-17 3TT0-A nrPDB 84 6e-17 5A46-A nrPDB 84 8e-17 4UY9-A nrPDB 84 8e-17 6CCF-A nrPDB 84 1e-16 4FR4-A nrPDB 83 1e-16 3ZZW-A nrPDB 83 1e-16 2PSQ-A nrPDB 83 2e-16 3A8W-A nrPDB 82 2e-16 5H2U-A nrPDB 82 2e-16 2XYN-A nrPDB 82 2e-16 3DTC-A nrPDB 82 2e-16 3DB8-A nrPDB 82 3e-16 6CTH-A nrPDB 82 3e-16 1FOT-A nrPDB 82 3e-16 4XCU-A nrPDB 82 3e-16 3QGY-A nrPDB 82 3e-16 6GVJ-A nrPDB 82 4e-16 5EG3-A nrPDB 81 5e-16 3HMP-A nrPDB 81 5e-16 4B6L-A nrPDB 81 5e-16 5AP3-A nrPDB 81 6e-16 2I0E-A nrPDB 81 7e-16 5B2L-A nrPDB 80 7e-16 2H8H-A nrPDB 80 8e-16 6BDL-A nrPDB 80 9e-16 2PL0-A nrPDB 80 1e-15 3PFQ-A nrPDB 80 1e-15 6F3F-A nrPDB 80 1e-15 6FER-A nrPDB 79 2e-15 3SXS-A nrPDB 79 2e-15 5UUU-A nrPDB 79 2e-15 5SYS-A nrPDB 79 2e-15 2X7G-A nrPDB 79 2e-15 5TOS-A nrPDB 79 2e-15 4AW2-A nrPDB 79 2e-15 4HVI-A nrPDB 79 2e-15 2ZMD-A nrPDB 79 3e-15 3PLS-A nrPDB 79 3e-15 3PVW-A nrPDB 79 3e-15 6DBM-A nrPDB 78 4e-15 3HDN-A nrPDB 78 4e-15 2RIO-A nrPDB 78 6e-15 4TNB-A nrPDB 77 6e-15 4AT3-A nrPDB 77 7e-15 1LUF-A nrPDB 77 7e-15 5KCV-A nrPDB 77 7e-15 4XI2-A nrPDB 77 7e-15 4E20-A nrPDB 77 9e-15 3DLS-A nrPDB 77 9e-15 5O2B-A nrPDB 77 1e-14 3MV5-A nrPDB 77 1e-14 5O2C-A nrPDB 77 1e-14 3TKU-A nrPDB 77 1e-14 4WUA-A nrPDB 76 1e-14 3I81-A nrPDB 76 1e-14 4OLI-A nrPDB 76 2e-14 6E4F-A nrPDB 76 2e-14 4C59-A nrPDB 75 2e-14 4PWN-A nrPDB 75 3e-14 4Y93-A nrPDB 75 3e-14 3A4O-X nrPDB 75 4e-14 4EBW-A nrPDB 75 4e-14 2J0K-A nrPDB 75 5e-14 3HKO-A nrPDB 75 5e-14 1U54-B nrPDB 75 5e-14 4HZS-A nrPDB 75 5e-14 5X5O-A nrPDB 74 6e-14 6J5U-C nrPDB 74 7e-14 2JD5-A nrPDB 74 9e-14 3C51-A nrPDB 74 9e-14 1VZO-A nrPDB 74 1e-13 3NYO-A nrPDB 74 1e-13 4K33-A nrPDB 74 1e-13 3FXW-A nrPDB 74 1e-13 4I6B-A nrPDB 74 1e-13 6HV0-A nrPDB 73 1e-13 6FEX-A nrPDB 73 1e-13 3C1X-A nrPDB 73 1e-13 5O0Y-A nrPDB 73 1e-13 4PL5-B nrPDB 73 2e-13 3ORP-A nrPDB 73 2e-13 4G3E-A nrPDB 73 2e-13 4RC3-A nrPDB 73 2e-13 3BGP-A nrPDB 73 2e-13 4NEU-A nrPDB 72 2e-13 4X7Q-B nrPDB 72 2e-13 5MJB-A nrPDB 72 3e-13 3DKO-A nrPDB 72 3e-13 2VD5-A nrPDB 72 3e-13 2DQ7-X nrPDB 72 4e-13 6BXI-A nrPDB 72 4e-13 6BFN-A nrPDB 72 4e-13 5TUR-A nrPDB 72 4e-13 3V5Q-A nrPDB 71 5e-13 5AMN-A nrPDB 71 5e-13 5XD6-A nrPDB 71 7e-13 2VWV-A nrPDB 71 7e-13 4YHJ-A nrPDB 71 7e-13 5L6P-A nrPDB 70 8e-13 4YFF-A nrPDB 70 8e-13 1K9A-A nrPDB 70 9e-13 1BYG-A nrPDB 70 9e-13 1AD5-A nrPDB 70 9e-13 2OU7-A nrPDB 70 1e-12 4J52-A nrPDB 70 1e-12 5HLW-A nrPDB 70 1e-12 1U59-A nrPDB 70 1e-12 6BSD-A nrPDB 70 1e-12 4IDT-A nrPDB 70 1e-12 5GNK-A nrPDB 70 1e-12 5U6C-A nrPDB 69 2e-12 2R2P-A nrPDB 69 2e-12 4LQP-A nrPDB 69 2e-12 3OMV-A nrPDB 69 2e-12 3LZB-A nrPDB 69 3e-12 5U6B-A nrPDB 69 3e-12 2QKW-B nrPDB 69 3e-12 2HK5-A nrPDB 69 3e-12 4F9B-A nrPDB 69 4e-12 3CJF-A nrPDB 68 5e-12 1JPA-A nrPDB 68 5e-12 3BBT-B nrPDB 68 6e-12 4XLV-A nrPDB 67 6e-12 4P5Q-A nrPDB 67 9e-12 2OZO-A nrPDB 67 9e-12 3KUL-B nrPDB 67 1e-11 2Y6O-A nrPDB 66 1e-11 4PDO-A nrPDB 66 1e-11 5KMM-A nrPDB 66 1e-11 3G2F-A nrPDB 65 3e-11 1FVR-A nrPDB 65 3e-11 3UIM-A nrPDB 65 3e-11 4JLC-A nrPDB 65 3e-11 5C26-A nrPDB 65 4e-11 4EUU-A nrPDB 65 4e-11 6NT9-A nrPDB 65 4e-11 4EUT-A nrPDB 65 5e-11 4OW8-A nrPDB 64 6e-11 6O8B-A nrPDB 64 6e-11 5FM2-A nrPDB 64 7e-11 4LRM-A nrPDB 64 7e-11 3LLT-A nrPDB 64 7e-11 2PMN-X nrPDB 64 8e-11 6B2Q-A nrPDB 64 8e-11 4X3F-A nrPDB 64 8e-11 2Y4I-B nrPDB 64 8e-11 4FL3-A nrPDB 64 9e-11 5LPV-A nrPDB 64 9e-11 3KA0-A nrPDB 64 1e-10 4H1J-A nrPDB 64 1e-10 5LPZ-A nrPDB 64 1e-10 1NY3-A nrPDB 63 2e-10 4M66-A nrPDB 63 2e-10 3HNG-A nrPDB 62 2e-10 2OZA-A nrPDB 62 2e-10 3MDY-A nrPDB 62 3e-10 2BUJ-A nrPDB 62 3e-10 5HI2-A nrPDB 62 3e-10 5WNO-A nrPDB 62 4e-10 5HIE-A nrPDB 62 4e-10 2WTK-B nrPDB 61 5e-10 3QD2-B nrPDB 61 7e-10 5IKW-A nrPDB 61 7e-10 4Y83-A nrPDB 60 9e-10 5TE0-A nrPDB 60 1e-09 5X02-A nrPDB 60 1e-09 4XUF-A nrPDB 60 1e-09 6GQK-A nrPDB 59 2e-09 5WNL-A nrPDB 59 3e-09 3ZBF-A nrPDB 59 4e-09 3PP0-A nrPDB 58 4e-09 4OTD-A nrPDB 58 5e-09 5GRN-A nrPDB 58 5e-09 4F0G-A nrPDB 58 6e-09 2H34-A nrPDB 57 8e-09 4CRS-A nrPDB 57 1e-08 3VHK-A nrPDB 56 2e-08 3KRL-A nrPDB 56 2e-08 3Q4U-A nrPDB 55 3e-08 5VDK-A nrPDB 55 3e-08 3BEA-A nrPDB 55 5e-08 3SOC-A nrPDB 54 7e-08 4R7H-A nrPDB 54 7e-08 1PY5-A nrPDB 54 7e-08 3AOX-A nrPDB 54 7e-08 3QUP-A nrPDB 53 1e-07 2OGV-A nrPDB 53 2e-07 5X1R-A nrPDB 52 3e-07 5X18-A nrPDB 52 3e-07 3G0E-A nrPDB 52 4e-07 4Y12-A nrPDB 50 8e-07 1CSN-A nrPDB 50 8e-07 5AR8-A nrPDB 50 1e-06 3LMG-A nrPDB 50 1e-06 4TN6-A nrPDB 50 1e-06 2PZI-A nrPDB 50 1e-06 4NFN-A nrPDB 50 1e-06 4BTK-A nrPDB 50 1e-06 5CEK-A nrPDB 50 1e-06 4RT7-A nrPDB 49 2e-06 6DC0-A nrPDB 49 2e-06 2QLU-A nrPDB 49 2e-06 5VC6-A nrPDB 49 3e-06 5FQD-C nrPDB 49 3e-06 3M42-A nrPDB 48 5e-06 4L00-A nrPDB 48 5e-06 3SV0-A nrPDB 48 6e-06 5L2Q-C nrPDB 48 6e-06 2CMW-A nrPDB 48 7e-06 5M07-A nrPDB 47 1e-05 4I94-A nrPDB 47 1e-05 4NT4-A nrPDB 47 1e-05 2C47-A nrPDB 46 2e-05 4O1O-A nrPDB 45 3e-05 3MY0-A nrPDB 45 4e-05 4XHH-A nrPDB 45 4e-05 4XHL-A nrPDB 45 5e-05 5E8V-A nrPDB 45 5e-05 4JRN-A nrPDB 44 6e-05 4OAU-C nrPDB 44 7e-05 2CHL-A nrPDB 44 8e-05 4IX6-A nrPDB 43 2e-04 5J0A-A nrPDB 41 8e-04 5USZ-A nrPDB 40 0.002 4BTF-A nrPDB 40 0.002 4M69-B nrPDB 39 0.002 4L68-A nrPDB 39 0.002 5OAT-A nrPDB 39 0.003 3REP-A nrPDB 39 0.003 5UV4-A nrPDB 37 0.008 4MWI-A nrPDB 36 0.016 4CYJ-A nrPDB 36 0.018 5CLR-A nrPDB 35 0.038 6J6I-B nrPDB 34 0.080 5UU1-A nrPDB 34 0.096 3G8O-A nrPDB 33 0.14 5DMZ-A nrPDB 33 0.15 4BWP-A nrPDB 33 0.15 3L9Y-A nrPDB 30 1.1 4AZW-A nrPDB 29 2.0 4AZV-A nrPDB 29 2.3 5XAR-A nrPDB 29 2.3 2RSV-A nrPDB 29 2.9 1OTJ-A nrPDB 29 2.9 2LAV-A nrPDB 28 3.5 6EQI-C nrPDB 28 4.6 1XSK-A nrPDB 28 4.7 6G4J-A nrPDB 28 4.8 5T9T-A nrPDB 28 5.4 5SZR-A nrPDB 28 5.5 4CI6-B nrPDB 27 9.6 >6GU6-A nrPDB Length = 302 Score = 611 bits (1576), Expect = e-175, Method: Compositional matrix adjust. Identities = 297/297 (100%), Positives = 297/297 (100%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH Sbjct: 6 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 65 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH Sbjct: 66 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 125 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR Sbjct: 126 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 185 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT Sbjct: 186 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 245 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM Sbjct: 246 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 302 >2BPM-A nrPDB Length = 309 Score = 405 bits (1042), Expect = e-114, Method: Compositional matrix adjust. Identities = 196/302 (64%), Positives = 236/302 (78%), Gaps = 11/302 (3%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ME++ K+EKIGEGTYGVVYK R+K TG+VVA+KKIRL++E EGVPSTAIREISLLKEL H Sbjct: 6 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 65 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDS-----IPPGQYMDSSLVKSYLYQILQG 115 PNIV L DV+ +++LYL+FEFL DLKK++D+ IP L+KSYL+Q+LQG Sbjct: 66 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIP------LPLIKSYLFQLLQG 119 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 + FCHS RVLHRDLKPQNLLI+ +G IKLADFGLARAFG+P+R YTHEVVTLWYR+PE+L Sbjct: 120 LAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEIL 179 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 LG YST VDIWS+G IFAE+ T++ LF GDSEIDQLFRIFR LGTP+ VWP V S+ Sbjct: 180 LGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP 239 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIK 295 DYK +FPKW + V LDE+G LLS+ML YDP KRIS K AL HP+F D+ + Sbjct: 240 DYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 299 Query: 296 KM 297 + Sbjct: 300 HL 301 >3NIZ-A nrPDB Length = 311 Score = 360 bits (923), Expect = e-100, Method: Compositional matrix adjust. Identities = 178/295 (60%), Positives = 223/295 (75%), Gaps = 4/295 (1%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ME Y K+EK+GEGTYGVVYK + + G++VA+K+IRL++E+EG+PSTAIREISLLKEL H Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAK-DSQGRIVALKRIRLDAEDEGIPSTAIREISLLKELHH 78 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNIVSL DV+ + L L+FEF+ DLKK LD G + S +K YLYQ+L+G+ CH Sbjct: 79 PNIVSLIDVIHSERCLTLVFEFMEKDLKKVLDENKTG--LQDSQIKIYLYQLLRGVAHCH 136 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 R+LHRDLKPQNLLI+ G +KLADFGLARAFGIP+R YTHEVVTLWYR+P+VL+GS + Sbjct: 137 QHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSKK 196 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 239 YST VDIWSIG IFAE+ T KPLF G ++ DQL +IF LGTPN WP+V+ L +K Sbjct: 197 YSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQR 256 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294 TF ++ +S + + G+DLLS ML +DP KRIS + A+NHPYF DLD QI Sbjct: 257 TFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDLDPQI 311 >1V0B-A nrPDB Length = 288 Score = 355 bits (910), Expect = 2e-98, Method: Compositional matrix adjust. Identities = 175/289 (60%), Positives = 213/289 (73%), Gaps = 3/289 (1%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ME Y +EKIGEGTYGVVYK ++ G+ A+KKIRLE E+EG+PST IREIS+LKEL+H Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKEDEGIPSTTIREISILKELKH 59 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 NIV L DV+ RL L+FE L DLKK LD G ++S KS+L Q+L GI +CH Sbjct: 60 SNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGG--LESVTAKSFLLQLLNGIAYCH 117 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 RRVLHRDLKPQNLLI+ +G +K+ADFGLARAFGIP+R YTHEVVTLWYR+P+VL+GS + Sbjct: 118 DRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKK 177 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 YST +DIWS+G IFAE+ PLF G SE DQL RIFR LGTPN++ WP V L Y Sbjct: 178 YSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPN 237 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 F ++P S +K LDE+G+DLLSKML DP +RI+ K AL H YF + Sbjct: 238 FTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >4AU8-A nrPDB Length = 296 Score = 335 bits (858), Expect = 2e-92, Method: Compositional matrix adjust. Identities = 165/291 (56%), Positives = 211/291 (72%), Gaps = 5/291 (1%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + Y K+EKIGEGTYG V+K +++ T ++VA+K++RL+ ++EGVPS+A+REI LLKEL+H Sbjct: 6 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 65 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L DVL D +L L+FEF DLKKY DS +D +VKS+L+Q+L+G+ FCHS Sbjct: 66 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSC--NGDLDPEIVKSFLFQLLKGLGFCHS 123 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 R VLHRDLKPQNLLI+ G +KLADFGLARAFGIP+R Y+ EVVTLWYR P+VL G+ Y Sbjct: 124 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 183 Query: 182 STPVDIWSIGTIFAELATK-KPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 ST +D+WS G IFAELA +PLF G+ DQL RIFR LGTP E WP + L DYK Sbjct: 184 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK-P 242 Query: 241 FPKW-KPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 +P + SL + V L+ G DLL +L +P +RIS + AL HPYF+D Sbjct: 243 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 293 >3GC0-A nrPDB Length = 329 Score = 327 bits (839), Expect = 3e-90, Method: Compositional matrix adjust. Identities = 171/299 (57%), Positives = 216/299 (72%), Gaps = 11/299 (3%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++ Y +I K+GEGTYG VYK T + VA+K+IRLE EEEGVP TAIRE+SLLKEL+H Sbjct: 33 IDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQH 92 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 NI+ L+ V+ + RL+LIFE+ DLKKY+D P + ++KS+LYQ++ G+ FCH Sbjct: 93 RNIIELKSVIHHNHRLHLIFEYAENDLKKYMDKNPD---VSMRVIKSFLYQLINGVNFCH 149 Query: 121 SRRVLHRDLKPQNLLID-----DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 SRR LHRDLKPQNLL+ + +K+ DFGLARAFGIPIR +THE++TLWYR PE+L Sbjct: 150 SRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEIL 209 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 LGS YST VDIWSI I+AE+ K PLF GDSEIDQLF+IF LG P++ WP V +L Sbjct: 210 LGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTALP 269 Query: 236 DYKNTFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--NDLD 291 D+K +FPK++ +L + LD+ GLDLL+ ML DP KRIS K AL HPYF ND D Sbjct: 270 DWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFSHNDFD 328 >5G6V-A nrPDB Length = 324 Score = 323 bits (829), Expect = 5e-89, Method: Compositional matrix adjust. Identities = 155/298 (52%), Positives = 215/298 (72%), Gaps = 4/298 (1%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ME Y K++K+GEGTY VYKG+ K T +VA+K+IRLE EEG P TAIRE+SLLK+L+H Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLE-HEEGAPCTAIREVSLLKDLKH 59 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 NIV+L D++ + L L+FE+L DLK+YLD G ++ VK +L+Q+L+G+ +CH Sbjct: 60 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDC--GNIINMHNVKLFLFQLLRGLAYCH 117 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 ++VLHRDLKPQNLLI+++G +KLADFGLARA IP + Y +EVVTLWYR P++LLGS Sbjct: 118 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTD 177 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 239 YST +D+W +G IF E+AT +PLF G + +QL IFR LGTP E WP + S +++K Sbjct: 178 YSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTY 237 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 +PK++ +L SH LD +G DLL+K+L ++ RIS + A+ HP+F L +I K+ Sbjct: 238 NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKL 295 >4KRC-A nrPDB Length = 317 Score = 305 bits (781), Expect = 1e-83, Method: Compositional matrix adjust. Identities = 153/294 (52%), Positives = 205/294 (69%), Gaps = 9/294 (3%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 + ++EK+G GTY VYKG +KTTG VA+K+++L+SEE G PSTAIREISL+KEL+H NI Sbjct: 7 FKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEE-GTPSTAIREISLMKELKHENI 65 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQY---MDSSLVKSYLYQILQGIVFCH 120 V L DV+ +++L L+FEF+ DLKKY+DS G ++ +LVK + +Q+LQG+ FCH Sbjct: 66 VRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCH 125 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 ++LHRDLKPQNLLI+ +G +KL DFGLARAFGIP+ ++ EVVTLWYR+P+VL+GS Sbjct: 126 ENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRT 185 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 YST +DIWS G I AE+ T KPLF G ++ +QL IF +GTPN +WP V L Y Sbjct: 186 YSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNPN 245 Query: 241 FPKWKPGSLAS----HVKN-LDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 + P L H K LD N +D L +L +P R+S K AL+HP+F + Sbjct: 246 IQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 >1G3N-A nrPDB Length = 326 Score = 264 bits (675), Expect = 3e-71, Method: Compositional matrix adjust. Identities = 139/300 (46%), Positives = 198/300 (66%), Gaps = 16/300 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRH-KTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR- 59 + Y + +IGEG YG V+K R K G+ VA+K++R+++ EEG+P + IRE+++L+ L Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 60 --HPNIVSLQDVLM-----QDSRLYLIFEFLSMDLKKYLDSIP-PGQYMDSSLVKSYLYQ 111 HPN+V L DV ++++L L+FE + DL YLD +P PG + + +K ++Q Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPG--VPTETIKDMMFQ 128 Query: 112 ILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRS 171 +L+G+ F HS RV+HRDLKPQN+L+ G IKLADFGLAR + + + T VVTLWYR+ Sbjct: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMAL-TSVVVTLWYRA 187 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PEVLL S+ Y+TPVD+WS+G IFAE+ +KPLF G S++DQL +I +G P E WP Sbjct: 188 PEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 Query: 232 ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 +L + F + V ++DE G DLL K L ++PAKRIS AL+HPYF DL+ Sbjct: 247 VALP--RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 >1UA2-A nrPDB Length = 346 Score = 256 bits (655), Expect = 6e-69, Method: Compositional matrix adjust. Identities = 130/290 (44%), Positives = 183/290 (63%), Gaps = 8/290 (2%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE---GVPSTAIREISLLKELRH 60 Y K++ +GEG + VYK R K T Q+VA+KKI+L E G+ TA+REI LL+EL H Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSH 71 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNI+ L D S + L+F+F+ DL+ + + S +K+Y+ LQG+ + H Sbjct: 72 PNIIGLLDAFGHKSNISLVFDFMETDLEVIIKD--NSLVLTPSHIKAYMLMTLQGLEYLH 129 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 +LHRDLKP NLL+D+ G +KLADFGLA++FG P R YTH+VVT WYR+PE+L G+ Sbjct: 130 QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM 189 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 Y VD+W++G I AEL + P GDS++DQL RIF LGTP E WP++ SL DY T Sbjct: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV-T 248 Query: 241 FPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 F + PG H+ ++ LDL+ + +++P RI+ AL YF++ Sbjct: 249 FKSF-PGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 >2W96-B nrPDB Length = 306 Score = 245 bits (625), Expect = 2e-65, Method: Compositional matrix adjust. Identities = 129/293 (44%), Positives = 185/293 (63%), Gaps = 13/293 (4%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR---H 60 Y + +IG G YG VYK R +G VA+K +R+ + EEG+P + +RE++LL+ L H Sbjct: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEH 65 Query: 61 PNIVSLQDVLM-----QDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 PN+V L DV ++ ++ L+FE + DL+ YLD PP + + +K + Q L+G Sbjct: 66 PNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG-LPAETIKDLMRQFLRG 124 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 + F H+ ++HRDLKP+N+L+ GT+KLADFGLAR + + + VVTLWYR+PEVL Sbjct: 125 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL-DPVVVTLWYRAPEVL 183 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 L S Y+TPVD+WS+G IFAE+ +KPLF G+SE DQL +IF +G P + WP SL Sbjct: 184 LQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP 242 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 + FP P + S V ++E+G LL +ML ++P KRIS AL H Y + Sbjct: 243 --RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 293 >5EFQ-A nrPDB Length = 347 Score = 236 bits (601), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 121/294 (41%), Positives = 183/294 (62%), Gaps = 14/294 (4%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 IGEGTYG VYK R K TG++VA+KK+RL++E+EG P TAIREI +L++L H +I++++++ Sbjct: 19 IGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEI 78 Query: 70 LMQD----------SRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 + YL+FE++ DL L+S + + + +KS++ Q+++G+ +C Sbjct: 79 VTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLES--GLVHFNENHIKSFMRQLMEGLDYC 136 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP-IRVYTHEVVTLWYRSPEVLLGS 178 H + LHRD+K N+L++++G IKLADFGLAR + R YT++V+TLWYR PE+LLG Sbjct: 137 HKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGE 196 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 RY+ +D+WS G I EL TKKP+F + E+ QL I R G+P VWP+V L + Sbjct: 197 ERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFN 256 Query: 239 NTFPKWK-PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 PK + L + LDL ML DP+KR + + AL + D++ Sbjct: 257 TMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVE 310 >4NST-A nrPDB Length = 351 Score = 233 bits (593), Expect = 1e-61, Method: Compositional matrix adjust. Identities = 122/294 (41%), Positives = 183/294 (62%), Gaps = 14/294 (4%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 IGEGTYG VYK + K TG++VA+KK+RL++E+EG P TAIREI +L++L H ++V+++++ Sbjct: 21 IGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEI 80 Query: 70 LM--QDS--------RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 + QD+ YL+FE++ DL L+S + +KS++ Q+++G+ +C Sbjct: 81 VTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLES--GLVHFSEDHIKSFMKQLMEGLEYC 138 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP-IRVYTHEVVTLWYRSPEVLLGS 178 H + LHRD+K N+L+++ G IKLADFGLAR + R YT++V+TLWYR PE+LLG Sbjct: 139 HKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGE 198 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 RY+ +D+WS G I EL TKKP+F + E+ QL I R G+P VWP+V L + Sbjct: 199 ERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFN 258 Query: 239 NTFPKWK-PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 PK + L + LDLL ML DP+KR + + L + D++ Sbjct: 259 TMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVE 312 >4AGU-A nrPDB Length = 311 Score = 229 bits (583), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 128/296 (43%), Positives = 179/296 (60%), Gaps = 12/296 (4%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGV-PSTAIREISLLKELR 59 ME Y KI KIGEG+YGVV+K R++ TGQ+VA+KK LESE++ V A+REI +LK+L+ Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKF-LESEDDPVIKKIALREIRMLKQLK 60 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HPN+V+L +V + RL+L+FE+ + LD G + LVKS +Q LQ + FC Sbjct: 61 HPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRG--VPEHLVKSITWQTLQAVNFC 118 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 H +HRD+KP+N+LI IKL DFG AR P Y EV T WYRSPE+L+G Sbjct: 119 HKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDT 178 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG--TPNNEVWPEVESLQDY 237 +Y PVD+W+IG +FAEL + PL+ G S++DQL+ I + LG P ++ +V S Y Sbjct: 179 QYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQ---QVFSTNQY 235 Query: 238 KNTFPKWKPGS---LASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 + P L N+ L LL L DP +R++ + L+HPYF ++ Sbjct: 236 FSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENI 291 >4BBM-A nrPDB Length = 331 Score = 228 bits (582), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 121/302 (40%), Positives = 174/302 (57%), Gaps = 28/302 (9%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ME Y + +GEG+YG+V K R+K TG++VA+KK +++ V A+REI LLK+LRH Sbjct: 24 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 83 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 N+V+L +V + R YL+FEF+ + L+ P G +D +V+ YL+QI+ GI FCH Sbjct: 84 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNG--LDYQVVQKYLFQIINGIGFCH 141 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 S ++HRD+KP+N+L+ G +KL DFG AR P VY EV T WYR+PE+L+G + Sbjct: 142 SHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVK 201 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGT---------PNNEVW--- 228 Y VD+W+IG + E+ +PLF GDS+IDQL+ I LG N V+ Sbjct: 202 YGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGV 261 Query: 229 --PEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 PE++ + + +PK L E +DL K L DP KR L+H + Sbjct: 262 RLPEIKEREPLERRYPK------------LSEVVIDLAKKCLHIDPDKRPFCAELLHHDF 309 Query: 287 FN 288 F Sbjct: 310 FQ 311 >3MIA-A nrPDB Length = 351 Score = 226 bits (577), Expect = 8e-60, Method: Compositional matrix adjust. Identities = 124/300 (41%), Positives = 182/300 (60%), Gaps = 19/300 (6%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y K+ KIG+GT+G V+K RH+ TGQ VA+KK+ +E+E+EG P TA+REI +L+ L+H N+ Sbjct: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Query: 64 VSLQDVLMQDS--------RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 V+L ++ + +YL+F+F DL L ++ + S +K + +L G Sbjct: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTL--SEIKRVMQMLLNG 136 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGI-----PIRVYTHEVVTLWYR 170 + + H ++LHRD+K N+LI G +KLADFGLARAF + P R YT+ VVTLWYR Sbjct: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR-YTNRVVTLWYR 195 Query: 171 SPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPE 230 PE+LLG Y P+D+W G I AE+ T+ P+ G++E QL I + G+ EVWP Sbjct: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 Query: 231 VESLQDY-KNTFPKWKPGSLASHVKNL--DENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 V++ + Y K K + + +K D LDL+ K+L+ DPA+RI ALNH +F Sbjct: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 >4BGQ-A nrPDB Length = 304 Score = 210 bits (535), Expect = 5e-55, Method: Compositional matrix adjust. Identities = 119/291 (40%), Positives = 173/291 (59%), Gaps = 7/291 (2%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 M + + +GEG YGVV K RHK T ++VA+KK + E E V T +RE+ +L+ L+ Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 70 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 NIV L++ + +LYL+FE++ ++ + L+ +P G + VKSY+YQ+++ I +CH Sbjct: 71 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNG--VPPEKVKSYIYQLIKAIHWCH 128 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV-YTHEVVTLWYRSPEVLLGSA 179 ++HRD+KP+NLLI +KL DFG AR Y EV T WYRSPE+LLG A Sbjct: 129 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLG-A 187 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGT-PNNEVWPEVESLQDYK 238 Y VD+WS+G I EL+ +PLF G+SEIDQLF I + LG P+ ++ + + + Sbjct: 188 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG 247 Query: 239 NTFPKWK-PGSLA-SHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 FP P SL ++ L+ LDL+ +L DPA R + LNHP F Sbjct: 248 LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 298 >3ZDU-A nrPDB Length = 325 Score = 204 bits (518), Expect = 4e-53, Method: Compositional matrix adjust. Identities = 113/303 (37%), Positives = 168/303 (55%), Gaps = 33/303 (10%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ME Y + K+GEG+YG V K +HK TGQ+VA+K I E E+ V A+REI LK+ H Sbjct: 2 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIK-IFYERPEQSVNKIAMREIKFLKQFHH 60 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 N+V+L +V Q +++L+FEF+ + L G ++S ++ YL+QIL+ I + H Sbjct: 61 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHG--LESKRLRKYLFQILRAIDYLH 118 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 S ++HRD+KP+N+L+ G KL DFG AR P +Y EV T WYR+PE++L Sbjct: 119 SNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTS 178 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG--TPNNE------------ 226 Y PVDIW++G + E+AT P S++D L +I +G +P+ + Sbjct: 179 YGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGV 238 Query: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGL--DLLSKMLIYDPAKRISGKMALNH 284 V P+V+ ++ + +PK NGL D++ L DPA RIS L+H Sbjct: 239 VLPQVQHPKNARKKYPKL--------------NGLLADIVHACLQIDPADRISSSDLLHH 284 Query: 285 PYF 287 YF Sbjct: 285 EYF 287 >5Z33-A nrPDB Length = 425 Score = 196 bits (499), Expect = 7e-51, Method: Compositional matrix adjust. Identities = 112/298 (37%), Positives = 163/298 (54%), Gaps = 14/298 (4%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR-H 60 E YT +++G+G YG+V + T + VA+KK+ ++ + A+REI LL+ R H Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGH 90 Query: 61 PNIVSLQDVLMQD----SRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 NI L D+ + + YL E + DL + S GQ + + +S++YQIL G+ Sbjct: 91 RNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRS---GQPLTDAHFQSFIYQILCGL 147 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR----VYTHEVVTLWYRSP 172 + HS VLHRDLKP NLL++ +K+ DFGLAR F + T V T WYR+P Sbjct: 148 KYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAP 207 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 E++L Y+ +D+WS+G I AEL +P F G +DQL +I LGTPN E + Sbjct: 208 EIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIG 267 Query: 233 S--LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 S Q+Y P + N + + LDLL +ML +DP+ RIS + AL HPY + Sbjct: 268 SPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYLH 325 >2F9G-A nrPDB Length = 353 Score = 194 bits (493), Expect = 4e-50, Method: Compositional matrix adjust. Identities = 109/297 (36%), Positives = 161/297 (54%), Gaps = 23/297 (7%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 +GEG YGVV HK TG++VA+KKI ++ +REI +LK +H NI+++ ++ Sbjct: 19 LGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENIITIFNI 77 Query: 70 LMQDS-----RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 124 DS +Y+I E + DL + + + Q + ++ ++YQ L+ + H V Sbjct: 78 QRPDSFENFNEVYIIQELMQTDLHRVIST----QMLSDDHIQYFIYQTLRAVKVLHGSNV 133 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI----------RVYTHEVVTLWYRSPEV 174 +HRDLKP NLLI+ +K+ DFGLAR T V T WYR+PEV Sbjct: 134 IHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEV 193 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTP---NNEVWPEV 231 +L SA+YS +D+WS G I AEL ++P+F G QL IF +GTP N+ E Sbjct: 194 MLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIES 253 Query: 232 ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 ++Y + P + L ++ G+DLL +ML++DPAKRI+ K AL HPY Sbjct: 254 PRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQ 310 >4CRL-A nrPDB Length = 406 Score = 194 bits (493), Expect = 4e-50, Method: Compositional matrix adjust. Identities = 118/315 (37%), Positives = 175/315 (55%), Gaps = 41/315 (13%) Query: 9 KIGEGTYGVVYKGRHKTTGQVV--AMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 K+G GTYG VYK + K A+K+I E G+ +A REI+LL+EL+HPN++SL Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 84 Query: 67 QDVLMQ--DSRLYLIFEFLSMDL-------KKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 Q V + D +++L+F++ DL + + P Q + +VKS LYQIL GI Sbjct: 85 QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQ-LPRGMVKSLLYQILDGIH 143 Query: 118 FCHSRRVLHRDLKPQNLLI----DDKGTIKLADFGLARAFGIPIRVYTH---EVVTLWYR 170 + H+ VLHRDLKP N+L+ ++G +K+AD G AR F P++ VVT WYR Sbjct: 144 YLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYR 203 Query: 171 SPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSE---------IDQLFRIFRALG 221 +PE+LLG+ Y+ +DIW+IG IFAEL T +P+FH E DQL RIF +G Sbjct: 204 APELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMG 263 Query: 222 TPNNEVWPEVESLQDYKNTFPKWKPGS---------LASHVKNLDENGLDLLSKMLIYDP 272 P ++ W +++ + ++ ++ + + H D LL K+L DP Sbjct: 264 FPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDP 323 Query: 273 AKRISGKMALNHPYF 287 KRI+ + A+ PYF Sbjct: 324 IKRITSEQAMQDPYF 338 >1CM8-A nrPDB Length = 367 Score = 192 bits (487), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 109/297 (36%), Positives = 160/297 (53%), Gaps = 15/297 (5%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y ++ +G G YG V TG VA+KK+ + E A RE+ LLK +RH N+ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 64 VSLQDVLMQDSRL------YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 + L DV D L YL+ F+ DL K + G+ ++ +YQ+L+G+ Sbjct: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGE----DRIQFLVYQMLKGLR 142 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 + H+ ++HRDLKP NL +++ +K+ DFGLAR + Y VVT WYR+PEV+L Sbjct: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGY---VVTRWYRAPEVILN 199 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES--LQ 235 RY+ VDIWS+G I AE+ T K LF G +DQL I + GTP E ++S + Sbjct: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 +Y P+ + AS + N ++LL KML+ D +R++ AL HPYF L + Sbjct: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 >4ZSG-A nrPDB Length = 347 Score = 192 bits (487), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 106/307 (34%), Positives = 171/307 (55%), Gaps = 18/307 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++Y IE IG G YGVV R + TGQ VA+KKI + +RE+ +LK +H Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 66 Query: 62 NIVSLQDVLM------QDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 NI++++D+L + +Y++ + + DL + + S P + V+ +LYQ+L+G Sbjct: 67 NIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQP---LTLEHVRYFLYQLLRG 123 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY----THEVVTLWYRS 171 + + HS +V+HRDLKP NLL+++ +K+ DFG+AR + T V T WYR+ Sbjct: 124 LKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 183 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PE++L Y+ +D+WS+G IF E+ ++ LF G + + QL I LGTP+ V V Sbjct: 184 PELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAV 243 Query: 232 --ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY--- 286 E ++ Y + P +P + D L LL +ML ++P+ RIS AL HP+ Sbjct: 244 GAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAK 303 Query: 287 FNDLDNQ 293 ++D D++ Sbjct: 304 YHDPDDE 310 >4IC8-A nrPDB Length = 442 Score = 191 bits (486), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 106/307 (34%), Positives = 171/307 (55%), Gaps = 18/307 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++Y IE IG G YGVV R + TGQ VA+KKI + +RE+ +LK +H Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 114 Query: 62 NIVSLQDVLM------QDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 NI++++D+L + +Y++ + + DL + + S Q + V+ +LYQ+L+G Sbjct: 115 NIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHS---SQPLTLEHVRYFLYQLLRG 171 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY----THEVVTLWYRS 171 + + HS +V+HRDLKP NLL+++ +K+ DFG+AR + T V T WYR+ Sbjct: 172 LKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 231 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PE++L Y+ +D+WS+G IF E+ ++ LF G + + QL I LGTP+ V V Sbjct: 232 PELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAV 291 Query: 232 --ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY--- 286 E ++ Y + P +P + D L LL +ML ++P+ RIS AL HP+ Sbjct: 292 GAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAK 351 Query: 287 FNDLDNQ 293 ++D D++ Sbjct: 352 YHDPDDE 358 >6DTL-A nrPDB Length = 364 Score = 189 bits (479), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 107/290 (36%), Positives = 160/290 (55%), Gaps = 10/290 (3%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 I IG+G YG+V + T + VA+KKI + + +REI LL+ + H NIV++ Sbjct: 35 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 94 Query: 67 QDVLMQDSR-----LYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +D++ R +Y+ +E + DL + + S Q + + +LYQIL+G+ + HS Sbjct: 95 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS---NQALSEEHCQYFLYQILRGLKYIHS 151 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 VLHRDLKP NLL++ +K+ DFGLAR T VVT WYR+PE+LL S+ Y Sbjct: 152 ANVLHRDLKPSNLLLNANCDLKICDFGLARVTS-ESDFMTEYVVTRWYRAPELLLNSSDY 210 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL-QDYKNT 240 + +D+WS+G IF EL +KPLF G + QL + +GTP+ E + + Y Sbjct: 211 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 270 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 P + S+ + +DL+ KML +DP +RI+ AL HPY N L Sbjct: 271 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSL 320 >3OZ6-A nrPDB Length = 388 Score = 187 bits (475), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 116/337 (34%), Positives = 184/337 (54%), Gaps = 52/337 (15%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR- 59 + Y ++K+G+G YG+V+K + TG+VVA+KKI + REI +L EL Sbjct: 8 LRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSG 67 Query: 60 HPNIVSLQDVLMQDSR--LYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 H NIV+L +VL D+ +YL+F+++ DL ++ ++ + +YQ+++ I Sbjct: 68 HENIVNLLNVLRADNDRDVYLVFDYMETDLH----AVIRANILEPVHKQYVVYQLIKVIK 123 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--------GIPIRV---------- 159 + HS +LHRD+KP N+L++ + +K+ADFGL+R+F IP+ + Sbjct: 124 YLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDD 183 Query: 160 ---YTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRI 216 T V T WYR+PE+LLGS +Y+ +D+WS+G I E+ KP+F G S ++QL RI Sbjct: 184 QPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLERI 243 Query: 217 FRALGTPNNEVWPEVESLQ--------------------DYKNTFPKWKPGSLASHVK-N 255 + P+NE +VES+Q + ++ F KWK L + K + Sbjct: 244 IGVIDFPSNE---DVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKAD 300 Query: 256 LDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 +E LDLL K+L ++P KRIS AL HP+ + N Sbjct: 301 CNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHN 337 >4QTB-A nrPDB Length = 380 Score = 185 bits (470), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 110/297 (37%), Positives = 164/297 (55%), Gaps = 21/297 (7%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 YT+++ IGEG YG+V VA+KKI E + +REI +L RH N+ Sbjct: 43 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHENV 101 Query: 64 VSLQDVL-------MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 + ++D+L M+D +Y++ + + DL K L S Q + + + +LYQIL+G+ Sbjct: 102 IGIRDILRASTLEAMRD--VYIVQDLMETDLYKLLKS----QQLSNDHICYFLYQILRGL 155 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP----IRVYTHEVVTLWYRSP 172 + HS VLHRDLKP NLLI+ +K+ DFGLAR P T V T WYR+P Sbjct: 156 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAP 214 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 E++L S Y+ +DIWS+G I AE+ + +P+F G +DQL I LG+P+ E + Sbjct: 215 EIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 274 Query: 233 SLQ--DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 +++ +Y + P + A D LDLL +ML ++P KRI+ + AL HPY Sbjct: 275 NMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 331 >5NGU-A nrPDB Length = 381 Score = 183 bits (464), Expect = 9e-47, Method: Compositional matrix adjust. Identities = 108/294 (36%), Positives = 157/294 (53%), Gaps = 15/294 (5%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 YT + IGEG YG+V VA+KKI E + +REI +L RH NI Sbjct: 44 YTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENI 102 Query: 64 VSLQDVLM-----QDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 + + D++ Q +Y++ + + DL K L + Q++ + + +LYQIL+G+ + Sbjct: 103 IGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKT----QHLSNDHICYFLYQILRGLKY 158 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP---IRVYTHEVVTLWYRSPEVL 175 HS VLHRDLKP NLL++ +K+ DFGLAR T V T WYR+PE++ Sbjct: 159 IHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIM 218 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 L S Y+ +DIWS+G I AE+ + +P+F G +DQL I LG+P+ E + +L+ Sbjct: 219 LNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 278 Query: 236 --DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 +Y + P N D LDLL KML ++P KRI + AL HPY Sbjct: 279 ARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 332 >4O2Z-A nrPDB Length = 377 Score = 179 bits (454), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 109/305 (35%), Positives = 167/305 (54%), Gaps = 26/305 (8%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIR--LESEEEGVPSTAIREISLLKELRHP 61 YT ++ +G G YG+ TG+ V++KK R E+G +REI +++ H Sbjct: 47 YTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDG--KRVLREIDMMRFFHHE 104 Query: 62 NIVSLQDVLMQDSRLYLIFE-------FLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 N++++ ++L R Y FE + +D+ L S Q ++ S ++ ++YQIL+ Sbjct: 105 NLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRS---RQVLEESHMQYFVYQILR 161 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 G+ + HS V HRDLKP NL+ + +K+ DFGL+R+ +P T V+T WYR PE+ Sbjct: 162 GLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPEL 221 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTP------NNEVW 228 LL + YST VDIWS+G IFAE+ +KP+F G + +DQL I + +G P + E Sbjct: 222 LLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREAL 281 Query: 229 PEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 ++ L D PK PG LA + + G+D LSKM DP+KR + L HPY Sbjct: 282 EKLNELPDGSLNIPKLVPG-LAGNTE-----GIDFLSKMWTLDPSKRPTAADMLAHPYLA 335 Query: 289 DLDNQ 293 L ++ Sbjct: 336 HLHDE 340 >4MYG-A nrPDB Length = 372 Score = 178 bits (451), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 107/296 (36%), Positives = 150/296 (50%), Gaps = 22/296 (7%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y +G G YG V K +G+ VA+KK+ + E A RE+ LLK ++H N+ Sbjct: 45 YVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENV 104 Query: 64 VSLQDVLMQDSRL------YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 + L DV S L YL+ F+ DL+K + G ++ +YQ+L+G+ Sbjct: 105 IGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIM-----GMEFSEEKIQYLVYQMLKGLK 159 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 + HS V+HRDLKP NL +++ +K+ DFGLAR + Y VVT WYR+PEV+L Sbjct: 160 YIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGY---VVTRWYRAPEVILS 216 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD- 236 Y+ VDIWS+G I AE+ T K LF G +DQL +I + G P E V+ L D Sbjct: 217 WMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF---VQKLNDK 273 Query: 237 ----YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 Y + P+ DLL KML D KR++ AL HP+F Sbjct: 274 AAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFE 329 >4EWQ-A nrPDB Length = 383 Score = 176 bits (446), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 106/294 (36%), Positives = 157/294 (53%), Gaps = 15/294 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E Y + +G G YG V TG VA+KK+ + RE+ LLK ++H Sbjct: 45 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 104 Query: 62 NIVSLQDV------LMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 N++ L DV L + + +YL+ + DL ++I Q + V+ +YQIL+G Sbjct: 105 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADL----NNIVKCQKLTDDHVQFLIYQILRG 160 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 + + HS ++HRDLKP NL +++ +K+ DFGLAR + Y V T WYR+PE++ Sbjct: 161 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEIM 217 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV--ES 233 L Y+ VDIWS+G I AEL T + LF G IDQL I R +GTP E+ ++ ES Sbjct: 218 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 277 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 ++Y + + + A+ + +DLL KML+ D KRI+ AL H YF Sbjct: 278 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF 331 >3OHT-A nrPDB Length = 389 Score = 175 bits (443), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 105/295 (35%), Positives = 155/295 (52%), Gaps = 15/295 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E Y + +G G YG V +G +A+KK+ + RE+ LLK ++H Sbjct: 51 ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 110 Query: 62 NIVSLQDVLMQDSRL------YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 N++ L DV + L YL+ + DL ++I Q + V+ +YQIL+G Sbjct: 111 NVIGLLDVFTPATSLEEFNDVYLVTHLMGADL----NNIVKCQKLTDDHVQFLIYQILRG 166 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 + + HS ++HRDLKP NL +++ +K+ DFGLAR + Y V T WYR+PE++ Sbjct: 167 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGY---VATRWYRAPEIM 223 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES-- 233 L Y+ VDIWS+G I AEL T + LF G I+QL +I R GTP V + S Sbjct: 224 LNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSHE 283 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 ++Y N+ P+ + A + +DLL KML+ D KRI+ AL HPYF+ Sbjct: 284 ARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFS 338 >3FI2-A nrPDB Length = 353 Score = 174 bits (440), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 113/307 (36%), Positives = 161/307 (52%), Gaps = 26/307 (8%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++ Y ++ IG G G+V + VA+KK+ + + A RE+ L+K + H Sbjct: 23 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 82 Query: 61 PNIVSL------QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 NI+SL Q L + +YL+ E + +L + + +D + LYQ+L Sbjct: 83 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-----MELDHERMSYLLYQMLC 137 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 GI HS ++HRDLKP N+++ T+K+ DFGLAR G + T VVT +YR+PEV Sbjct: 138 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEV 196 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE-S 233 +LG Y VDIWS+G I E+ K LF G IDQ ++ LGTP E +++ + Sbjct: 197 ILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 255 Query: 234 LQDYKN--------TFPKWKPGSL----ASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 +++Y TFPK P SL + H K DLLSKML+ DPAKRIS A Sbjct: 256 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 315 Query: 282 LNHPYFN 288 L HPY N Sbjct: 316 LQHPYIN 322 >1JNK-A nrPDB Length = 423 Score = 173 bits (439), Expect = 7e-44, Method: Compositional matrix adjust. Identities = 113/307 (36%), Positives = 161/307 (52%), Gaps = 26/307 (8%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++ Y ++ IG G G+V + VA+KK+ + + A RE+ L+K + H Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 Query: 61 PNIVSL------QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 NI+SL Q L + +YL+ E + +L + + +D + LYQ+L Sbjct: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-----MELDHERMSYLLYQMLC 175 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 GI HS ++HRDLKP N+++ T+K+ DFGLAR G + T VVT +YR+PEV Sbjct: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMM-TPYVVTRYYRAPEV 234 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE-S 233 +LG Y VDIWS+G I E+ K LF G IDQ ++ LGTP E +++ + Sbjct: 235 ILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 Query: 234 LQDYKN--------TFPKWKPGSL----ASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 +++Y TFPK P SL + H K DLLSKML+ DPAKRIS A Sbjct: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 Query: 282 LNHPYFN 288 L HPY N Sbjct: 354 LQHPYIN 360 >3GC9-A nrPDB Length = 370 Score = 171 bits (434), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 102/287 (35%), Positives = 154/287 (53%), Gaps = 15/287 (5%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 +G G YG V Q VA+KK+ + RE+ LLK L+H N++ L DV Sbjct: 36 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDV 95 Query: 70 L-----MQD-SRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 ++D S +YL+ + DL ++I Q + V+ +YQ+L+G+ + HS Sbjct: 96 FTPATSIEDFSEVYLVTTLMGADL----NNIVKSQALSDEHVQFLVYQLLRGLKYIHSAG 151 Query: 124 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYST 183 ++HRDLKP N+ +++ +++ DFGLAR + Y V T WYR+PE++L Y+ Sbjct: 152 IIHRDLKPSNVAVNEDSELRILDFGLARQADEEMTGY---VATRWYRAPEIMLNWMHYNQ 208 Query: 184 PVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV--ESLQDYKNTF 241 VDIWS+G I AEL K LF G IDQL RI +GTP+ EV ++ E + Y + Sbjct: 209 TVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSL 268 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 P L+S + + +DLL +ML+ D +R+S AL H YF+ Sbjct: 269 PPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFS 315 >4QNY-A nrPDB Length = 354 Score = 166 bits (420), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 97/302 (32%), Positives = 154/302 (50%), Gaps = 36/302 (11%) Query: 10 IGEGTYGVVYKGRH-KTTGQVVAMKKIRLESEEEGVPSTAI-REISLLKELRHPNIVSLQ 67 IG G+YGVV + R K+ ++VAMK++ E EE + + I REI LL NI+ L+ Sbjct: 28 IGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFNDDNIIGLR 87 Query: 68 DVLMQDS-----RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 ++L + Y++ + + DLK+ L S GQ + + ++ ++YQ L+ + HS Sbjct: 88 NILTPEDPENFDHFYIVMDIMETDLKQVLRS---GQELTEAHIQFFIYQALRALHIIHSA 144 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 V+HRD+ P N+L++ +K+ DFGLA+ T V WYR+PE+++ YS Sbjct: 145 GVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVMEDKDYS 204 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES--------- 233 +D+W IG I EL +PLF G ++QL +I +GTP+ E V S Sbjct: 205 AQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSAAQKYLKK 264 Query: 234 -----LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 D++ +P P LDLL ML+++P +RI+ A+ HP+ Sbjct: 265 KSHRPQADWRQRYPTASP------------EALDLLRHMLVFNPKRRITVLQAMRHPFLE 312 Query: 289 DL 290 L Sbjct: 313 QL 314 >4E7W-A nrPDB Length = 394 Score = 165 bits (418), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 99/307 (32%), Positives = 173/307 (56%), Gaps = 26/307 (8%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 YT + IG G++GVV++ + + +V A+KK+ + + RE+ +++ ++HPN+ Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDEV-AIKKVLQDKRFKN------RELQIMRIVKHPNV 94 Query: 64 VSLQDVLMQDSR------LYLIFEFLSMDLKKYLDSIPP-GQYMDSSLVKSYLYQILQGI 116 V L+ + L L+ E++ + + Q M L+K Y+YQ+L+ + Sbjct: 95 VDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSL 154 Query: 117 VFCHSRRVLHRDLKPQNLLIDD-KGTIKLADFGLARAF--GIPIRVYTHEVVTLWYRSPE 173 + HS + HRD+KPQNLL+D G +KL DFG A+ G P Y + + +YR+PE Sbjct: 155 AYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSY---ICSRYYRAPE 211 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 233 ++ G+ Y+T +DIWS G + AEL +PLF G+S IDQL I + LGTP+ E ++++ Sbjct: 212 LIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSRE---QIKT 268 Query: 234 LQD--YKNTFPKWKPGSLASHVK-NLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 + ++ FP+ +P + + + +DL+S++L Y P+ R++ AL HP+F++L Sbjct: 269 MNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDEL 328 Query: 291 DNQIKKM 297 +M Sbjct: 329 RTGEARM 335 >3E7O-A nrPDB Length = 360 Score = 164 bits (415), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 108/307 (35%), Positives = 154/307 (50%), Gaps = 26/307 (8%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++ Y +++ IG G G+V G VA+KK+ + + A RE+ LLK + H Sbjct: 21 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH 80 Query: 61 PNIVSL------QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 NI+SL Q L + +YL+ E + +L + + +D + LYQ+L Sbjct: 81 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-----MELDHERMSYLLYQMLC 135 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 GI HS ++HRDLKP N+++ T+K+ DFGLAR + T VVT +YR+PEV Sbjct: 136 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNF-MMTPYVVTRYYRAPEV 194 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNE----VWPE 230 +LG Y VDIWS+G I EL +F G IDQ ++ LGTP+ E + P Sbjct: 195 ILGMG-YKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPT 253 Query: 231 VESLQD---------YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 V + + ++ FP W S + K DLLSKML+ DP KRIS A Sbjct: 254 VRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEA 313 Query: 282 LNHPYFN 288 L HPY Sbjct: 314 LRHPYIT 320 >3E3P-A nrPDB Length = 360 Score = 161 bits (408), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 105/314 (33%), Positives = 166/314 (52%), Gaps = 27/314 (8%) Query: 3 DYTKIEKI-GEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL--- 58 D ++E++ G+GT+G V G+ K+TG VA+KK+ + P RE+ ++++L Sbjct: 23 DRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQD------PRFRNRELQIMQDLAVL 76 Query: 59 RHPNIVSLQDVLM-------QDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSS-LVKSYLY 110 HPNIV LQ +D L ++ E++ L + + Q L+K +L+ Sbjct: 77 HHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFLF 136 Query: 111 QILQGIVFCH--SRRVLHRDLKPQNLLIDDK-GTIKLADFGLARAFGIPIRVYTHEVVTL 167 Q+++ I H S V HRD+KP N+L+++ GT+KL DFG A+ P + + Sbjct: 137 QLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLS-PSEPNVAYICSR 195 Query: 168 WYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEV 227 +YR+PE++ G+ Y+T VDIWS+G IFAE+ +P+F GD+ QL I R LG P+ EV Sbjct: 196 YYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSREV 255 Query: 228 W----PEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 P + Y + W + H + DLLS +L Y P +R+ AL Sbjct: 256 LRKLNPSHTDVDLYNSKGIPWS-NVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEALC 314 Query: 284 HPYFNDLDNQIKKM 297 HPYF++L + K+ Sbjct: 315 HPYFDELHDPATKL 328 >3RP9-A nrPDB Length = 458 Score = 160 bits (406), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 111/346 (32%), Positives = 160/346 (46%), Gaps = 68/346 (19%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 IG G+YG V + K +VVA+KKI E+ +REI++L L H ++V + D+ Sbjct: 61 IGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVLDI 120 Query: 70 LMQDS-----RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 124 ++ LY++ E D KK + Y+ +K+ LY +L G+ + HS + Sbjct: 121 VIPKDVEKFDELYVVLEIADSDFKKLFRT---PVYLTELHIKTLLYNLLVGVKYVHSAGI 177 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIP---------------------------I 157 LHRDLKP N L++ ++K+ DFGLAR P Sbjct: 178 LHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLK 237 Query: 158 RVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL-----------ATKKPLFHG 206 R T VVT WYR+PE++L Y+ +D+WSIG IFAEL A + PLF G Sbjct: 238 RQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYHADRGPLFPG 297 Query: 207 DSEI--------------------DQLFRIFRALGTPNNEVWP--EVESLQDYKNTFPKW 244 S DQL IF LGTP+ E E E + Y FPK Sbjct: 298 SSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAKRYIRIFPKR 357 Query: 245 KPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 + LA + + LL +ML+++P KRI+ L HP+F ++ Sbjct: 358 EGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEV 403 >3N9X-A nrPDB Length = 432 Score = 160 bits (405), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 107/338 (31%), Positives = 158/338 (46%), Gaps = 60/338 (17%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 IG G+YG VY K T + VA+KK+ E+ +REI++L L+ I+ L D+ Sbjct: 34 IGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLYDL 93 Query: 70 LMQDS-----RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 124 ++ D LY++ E DLKK + ++ +K+ LY +L G F H + Sbjct: 94 IIPDDLLKFDELYIVLEIADSDLKKLFKT---PIFLTEEHIKTILYNLLLGENFIHESGI 150 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIP----------------------IRVYTH 162 +HRDLKP N L++ ++K+ DFGLAR + T Sbjct: 151 IHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQLTS 210 Query: 163 EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL-----------ATKKPLF------- 204 VVT WYR+PE++L Y+ +DIWS G IFAEL + PLF Sbjct: 211 HVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLFPGSSCFP 270 Query: 205 ----------HGDSEIDQLFRIFRALGTPNNEVWPEVESLQ--DYKNTFPKWKPGSLASH 252 H S DQL IF +GTP + + + Y FP KP +L Sbjct: 271 LSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPHRKPINLKQK 330 Query: 253 VKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 ++ ++G++LL ML ++P KRI+ AL+HPY D+ Sbjct: 331 YPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDV 368 >2XS0-A nrPDB Length = 386 Score = 157 bits (398), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 103/307 (33%), Positives = 152/307 (49%), Gaps = 26/307 (8%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++ Y ++ IG G G+V + VA+KK+ + + A RE+ L+K + H Sbjct: 25 LKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 84 Query: 61 PNIVSLQDVLMQDSRL------YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 NI+ L +V L Y++ E + +L + + +D + LYQ+L Sbjct: 85 KNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-----MELDHERMSYLLYQMLC 139 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 GI HS ++HRDLKP N+++ T+K+ DFGLAR G + VVT +YR+PEV Sbjct: 140 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPF-VVTRYYRAPEV 198 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE-S 233 +LG Y VDIWS+G I E+ LF G IDQ ++ LGTP E +++ + Sbjct: 199 ILGMG-YKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPT 257 Query: 234 LQDYKNTFPKWKPGSL------------ASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 ++ Y PK+ S + H K DLLSKML+ D +KRIS A Sbjct: 258 VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEA 317 Query: 282 LNHPYFN 288 L HPY N Sbjct: 318 LQHPYIN 324 >3EB0-A nrPDB Length = 383 Score = 156 bits (394), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 106/341 (31%), Positives = 171/341 (50%), Gaps = 71/341 (20%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y+ + +G G++G+V + +G+ A+KK+ + P RE+ ++K L H NI Sbjct: 9 YSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQD------PRYKNRELDIMKVLDHVNI 62 Query: 64 VSLQDVLM--------------------------------------QDSRLYLIFEFLSM 85 + L D Q+ L +I E++ Sbjct: 63 IKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPD 122 Query: 86 DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDK-GTIK 143 L K L S I G+ + +L+ Y+YQ+ + + F HS + HRD+KPQNLL++ K T+K Sbjct: 123 TLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLK 182 Query: 144 LADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPL 203 L DFG A+ IP + + +YR+PE++LG+ Y+ +D+WSIG +F EL KPL Sbjct: 183 LCDFGSAKKL-IPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPL 241 Query: 204 FHGDSEIDQLFRIFRALGTPNNEV------------WPEVESLQDYKNTFPKWKPGSLAS 251 F G++ IDQL RI + +GTP E +P +++ +D++ P+ P SLA Sbjct: 242 FSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKA-KDWRKILPEGTP-SLA- 298 Query: 252 HVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 +DLL ++L Y+P RI+ A+ HP+F+ L N Sbjct: 299 ---------IDLLEQILRYEPDLRINPYEAMAHPFFDHLRN 330 >3PG1-A nrPDB Length = 362 Score = 153 bits (387), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 102/309 (33%), Positives = 154/309 (49%), Gaps = 31/309 (10%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEG----------VPSTAIREIS 53 YT I G+YG V G + G VA+K++ + +G + +REI Sbjct: 24 YTVQRFISSGSYGAVCAGV-DSEGIPVAIKRV-FNTVSDGRTVNILSDSFLCKRVLREIR 81 Query: 54 LLKELRHPNIVSLQDVLMQDS-----RLYLIFEFLSMDLKKYLDS----IPPGQYMDSSL 104 LL HPNI+ L+D+ + +LYL+ E + DL + + I P Sbjct: 82 LLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQH------ 135 Query: 105 VKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV 164 ++ ++Y IL G+ H V+HRDL P N+L+ D I + DF LAR TH V Sbjct: 136 IQYFMYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADAN-KTHYV 194 Query: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPN 224 WYR+PE+++ ++ VD+WS G + AE+ +K LF G + +QL +I +GTP Sbjct: 195 THRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPK 254 Query: 225 NE--VWPEVESLQDY-KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 E V S +DY +N+ + + V D LDL++KML ++P +RIS + A Sbjct: 255 IEDVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQA 314 Query: 282 LNHPYFNDL 290 L HPYF L Sbjct: 315 LRHPYFESL 323 >5AWM-A nrPDB Length = 394 Score = 153 bits (387), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 102/305 (33%), Positives = 150/305 (49%), Gaps = 27/305 (8%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y + IG G G+V T Q VA+KK+ + A RE L+K + H NI Sbjct: 46 YINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNI 105 Query: 64 VSL------QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 + L Q L + +YL+ E + +L + + +D + LYQ+L GI Sbjct: 106 IGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ-----MDLDHDRMSYLLYQMLCGIK 160 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 HS ++HRDLKP N+++ T+K+ DFGLAR G + T VVT +YR+PEV+LG Sbjct: 161 HLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEVILG 219 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE-SLQD 236 Y+ VDIWS+G I E+ LF G IDQ +I LGTP+ ++ ++++ Sbjct: 220 MG-YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVRN 278 Query: 237 YKNTFPKWK-------------PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 Y P++ P + + + +LLSKML+ DP +RIS AL Sbjct: 279 YVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALK 338 Query: 284 HPYFN 288 H Y N Sbjct: 339 HEYIN 343 >3NIE-A nrPDB Length = 429 Score = 153 bits (387), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 106/341 (31%), Positives = 155/341 (45%), Gaps = 63/341 (18%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 IG G+YG VY K + VA+KK+ E+ +REI++L L+ I+ L D+ Sbjct: 36 IGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLHDL 95 Query: 70 -----LMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 124 L++ LY++ E DLKK + ++ VK+ LY +L G F H + Sbjct: 96 IIPEDLLKFDELYIVLEIADSDLKKLFKT---PIFLTEQHVKTILYNLLLGEKFIHESGI 152 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY------------------------ 160 +HRDLKP N L++ ++K+ DFGLAR ++ Sbjct: 153 IHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPHNKNLKKQ 212 Query: 161 -THEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL-----------ATKKPLF---- 204 T VVT WYR+PE++L Y+ +DIWS G IFAEL + PLF Sbjct: 213 LTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRFPLFPGSS 272 Query: 205 -------------HGDSEIDQLFRIFRALGTPNNEVWPEV--ESLQDYKNTFPKWKPGSL 249 H S DQL IF +GTP E + + + Y FP L Sbjct: 273 CFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLFPTRDGIDL 332 Query: 250 ASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 + ++ + G+DLL ML ++ KRI+ AL+HPY D+ Sbjct: 333 SKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDV 373 >5AIR-A nrPDB Length = 430 Score = 152 bits (384), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 96/300 (32%), Positives = 162/300 (54%), Gaps = 25/300 (8%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 YT + IG G++GVVY+ + +G++VA+KK+ + + RE+ ++++L H NI Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 119 Query: 64 VSLQDVLMQDSR------LYLIFEFLSMDLKKYLDSIPPG-QYMDSSLVKSYLYQILQGI 116 V L+ L L+ +++ + + Q + VK Y+YQ+ + + Sbjct: 120 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 179 Query: 117 VFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF--GIPIRVYTHEVVTLWYRSPE 173 + HS + HRD+KPQNLL+D D +KL DFG A+ G P Y + + +YR+PE Sbjct: 180 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPE 236 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE- 232 ++ G+ Y++ +D+WS G + AEL +P+F GDS +DQL I + LGTP E E+ Sbjct: 237 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 296 Query: 233 SLQDYKNTFPKWK--PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 + ++K FP+ K P + + E + L S++L Y P R++ A H +F++L Sbjct: 297 NYTEFK--FPQIKAHPWTKVFRPRTPPE-AIALCSRLLEYTPTARLTPLEACAHSFFDEL 353 >2I6L-A nrPDB Length = 320 Score = 141 bits (356), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 95/309 (30%), Positives = 161/309 (52%), Gaps = 35/309 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y ++ +G G G+V+ + VA+KKI L ++ + V A+REI +++ L H NI Sbjct: 13 YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVL-TDPQSV-KHALREIKIIRRLDHDNI 70 Query: 64 VSLQDVL--------------MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYL 109 V + ++L + + +Y++ E++ DL L+ P + + ++ Sbjct: 71 VKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGP----LLEEHARLFM 126 Query: 110 YQILQGIVFCHSRRVLHRDLKPQNLLIDDKG-TIKLADFGLARAFGIPIRVYTHE----- 163 YQ+L+G+ + HS VLHRDLKP NL I+ + +K+ DFGLAR Y+H+ Sbjct: 127 YQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMD---PHYSHKGHLSE 183 Query: 164 -VVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGT 222 +VT WYRSP +LL Y+ +D+W+ G IFAE+ T K LF G E++Q+ I ++ Sbjct: 184 GLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPV 243 Query: 223 PNNEVWPEVESLQDY---KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGK 279 + E E+ S+ + KP L + + +D L ++L + P R++ + Sbjct: 244 VHEEDRQELLSVIPVYIRNDMTEPHKP--LTQLLPGISREAVDFLEQILTFSPMDRLTAE 301 Query: 280 MALNHPYFN 288 AL+HPY + Sbjct: 302 EALSHPYMS 310 >4MVF-A nrPDB Length = 506 Score = 139 bits (351), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 98/291 (33%), Positives = 148/291 (50%), Gaps = 45/291 (15%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAM---KKIRLESEEEGVPSTAIREISLLKELRHPNIV 64 EK+G+GTYG VYKG K T Q+ A+ KK RL++ + +EI ++K+L HPNIV Sbjct: 63 EKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKN-----INRFFQEIEIMKKLDHPNIV 117 Query: 65 SLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 124 L + D+ +YLI E S ++ DSI + + QI I + HS + Sbjct: 118 KLYETYENDNYIYLIMELCSG--RELFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNI 175 Query: 125 LHRDLKPQNLLIDDKGT---IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 +HRDLKP+N L + +K+ DFGL++ G T + T +Y +P+VL G +Y Sbjct: 176 VHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTG-EFTTTKAGTPYYVAPQVLDG--KY 232 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 241 DIWS G I L P F+GD++ NEV +V+ K F Sbjct: 233 DKKCDIWSSGVIMYTLLCGYPPFYGDTD---------------NEVLKKVK-----KGEF 272 Query: 242 PKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 ++ GS++S KN L++K+L Y+P +R + + ALNHP+ + Sbjct: 273 CFYENDWGSISSDAKN-------LITKLLTYNPNERCTIEEALNHPWITQM 316 >3NCG-A nrPDB Length = 486 Score = 135 bits (339), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 87/288 (30%), Positives = 139/288 (48%), Gaps = 33/288 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E Y + +G+G++G V K + + T Q A+K I S + ST +RE+ LLK+L HP Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NI+ L ++L S Y++ E + + D I + + Q+ GI + H Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTG--GELFDEIIKRKRFSEHDAARIIKQVFSGITYMHK 139 Query: 122 RRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 ++HRDLKP+N+L++ K IK+ DFGL+ F ++ + T +Y +PEVL G+ Sbjct: 140 HNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKM-KDRIGTAYYIAPEVLRGT 198 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y D+WS G I L + P F+G +E D L R+ Y Sbjct: 199 --YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV----------------ETGKYA 240 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 P+W + + ++ DL+ KML + P+ RI+ L HP+ Sbjct: 241 FDLPQW---------RTISDDAKDLIRKMLTFHPSLRITATQCLEHPW 279 >3DFA-A nrPDB Length = 286 Score = 135 bits (339), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 87/288 (30%), Positives = 139/288 (48%), Gaps = 33/288 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E Y + +G+G++G V K + + T Q A+K I S + ST +RE+ LLK+L HP Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NI+ L ++L S Y++ E + + D I + + Q+ GI + H Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGG--ELFDEIIKRKRFSEHDAARIIKQVFSGITYMHK 139 Query: 122 RRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 ++HRDLKP+N+L++ K IK+ DFGL+ F ++ + T +Y +PEVL G+ Sbjct: 140 HNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKM-KDRIGTAYYIAPEVLRGT 198 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y D+WS G I L + P F+G +E D L R+ Y Sbjct: 199 --YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV----------------ETGKYA 240 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 P+W + + ++ DL+ KML + P+ RI+ L HP+ Sbjct: 241 FDLPQW---------RTISDDAKDLIRKMLTFHPSLRITATQCLEHPW 279 >5YKS-A nrPDB Length = 377 Score = 133 bits (334), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 93/284 (32%), Positives = 138/284 (48%), Gaps = 34/284 (11%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 +G G + VV RH TG+ VA+K I + +E+ +K ++HPNIV L +V Sbjct: 43 LGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEV 102 Query: 70 LMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 + ++LYLI E D+ Y+ G ++ L K Y QI+ I +CH V+HRD Sbjct: 103 IDTQTKLYLILELGDGGDMFDYIMKHEEG--LNEDLAKKYFAQIVHAISYCHKLHVVHRD 160 Query: 129 LKPQNLLIDDK-GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDI 187 LKP+N++ +K G +KL DFG + F P + T +L Y +PE+LLG + VDI Sbjct: 161 LKPENVVFFEKQGLVKLTDFGFSNKFQ-PGKKLTTSCGSLAYSAPEILLGDEYDAPAVDI 219 Query: 188 WSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPG 247 WS+G I L +P F ++ + L I D K T P Sbjct: 220 WSLGVILFMLVCGQPPFQEANDSETLTMIM------------------DCKYTVP----- 256 Query: 248 SLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 SHV + DL+++ML DP +R S + NHP+ +D Sbjct: 257 ---SHVS---KECKDLITRMLQRDPKRRASLEEIENHPWLQGVD 294 >5XVU-A nrPDB Length = 332 Score = 130 bits (326), Expect = 9e-31, Method: Compositional matrix adjust. Identities = 101/301 (33%), Positives = 165/301 (54%), Gaps = 26/301 (8%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH-PN 62 Y ++KIG G Y V+ G + A+K ++ + REI +L+ L PN Sbjct: 33 YEIMKKIGRGKYSEVFNGYDTECNRPCAIKVLKPVKK-----KKIKREIKILQNLNGGPN 87 Query: 63 IVSLQDVLMQ--DSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 I+ L D++ LIFE+++ +D K ++ P ++ D ++ Y+YQIL+ + +C Sbjct: 88 IIKLLDIVKDPVTKTPSLIFEYINNIDFK----TLYP-KFTDKD-IRYYIYQILKALDYC 141 Query: 120 HSRRVLHRDLKPQNLLIDDKG-TIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 HS+ ++HRD+KP N++ID + I+L +GLA F P + Y V + +Y+ PE+L+ Sbjct: 142 HSQGIMHRDVKPHNIMIDHENRQIRLISWGLAE-FYHPGQEYNVRVASRYYKGPELLIDL 200 Query: 179 ARYSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ-- 235 Y +DIWS+G + A + KK P F G DQL +I + LGT + + + +++ Sbjct: 201 QLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIKLK 260 Query: 236 -DYKNTFPKW--KPGSLASHVKNLD---ENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 Y N ++ KP S N+D + +DL+ KMLIYD AKRI+ K A+ HPYF + Sbjct: 261 PHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEHPYFRE 320 Query: 290 L 290 + Sbjct: 321 V 321 >3LIJ-A nrPDB Length = 494 Score = 129 bits (325), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 91/292 (31%), Positives = 137/292 (46%), Gaps = 33/292 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E Y +++K+G G YG V R K T A+K IR S S + E+++LK L HP Sbjct: 37 EMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHP 96 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NI+ L D YL+ E + D I + + Q+L G+ + H Sbjct: 97 NIMKLYDFFEDKRNYYLVMECYKGG--ELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHK 154 Query: 122 RRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 ++HRDLKP+NLL++ K IK+ DFGL+ F ++ + T +Y +PEVL Sbjct: 155 HNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKM-KERLGTAYYIAPEVL--R 211 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 +Y D+WSIG I L P F G + + E+ +VE + Y Sbjct: 212 KKYDEKCDVWSIGVILFILLAGYPPFGGQT---------------DQEILRKVEKGK-YT 255 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 P+W KN+ E DL+ +ML +D +RIS + AL HP+ ++ Sbjct: 256 FDSPEW---------KNVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEM 298 >3MA6-A nrPDB Length = 298 Score = 128 bits (322), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 86/283 (30%), Positives = 141/283 (49%), Gaps = 34/283 (12%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 +G+G++G V + K TGQ A+K I + + +++ + +RE+ LLK+L HPNI+ L + Sbjct: 40 LGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYE 99 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 YL+ E + + D I + + Q+L GI + H +++HRD Sbjct: 100 FFEDKGYFYLVGEVYTGG--ELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRD 157 Query: 129 LKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPV 185 LKP+NLL++ K I++ DFGL+ F ++ ++ T +Y +PEVL G+ Y Sbjct: 158 LKPENLLLESKSKDANIRIIDFGLSTHFEASKKM-KDKIGTAYYIAPEVLHGT--YDEKC 214 Query: 186 DIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWK 245 D+WS G I L + P F+G +E D L ++ + Y P+W Sbjct: 215 DVWSTGVILYILLSGCPPFNGANEYDILKKVEKG----------------KYTFELPQW- 257 Query: 246 PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 K + E+ DL+ KML Y P+ RIS + AL+H + Sbjct: 258 --------KKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQ 292 >5JN2-A nrPDB Length = 525 Score = 128 bits (322), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 86/281 (30%), Positives = 141/281 (50%), Gaps = 34/281 (12%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 +G+G++G V + K TGQ A+K I + + +++ + +RE+ LLK+L HPNI+ L + Sbjct: 75 LGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYE 134 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 YL+ E + + D I + + Q+L GI + H +++HRD Sbjct: 135 FFEDKGYFYLVGEVYTGG--ELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRD 192 Query: 129 LKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPV 185 LKP+NLL++ K I++ DFGL+ F ++ ++ T +Y +PEVL G+ Y Sbjct: 193 LKPENLLLESKSKDANIRIIDFGLSTHFEASKKM-KDKIGTAYYIAPEVLHGT--YDEKC 249 Query: 186 DIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWK 245 D+WS G I L + P F+G +E D L ++ + Y P+W Sbjct: 250 DVWSTGVILYILLSGCPPFNGANEYDILKKVEKG----------------KYTFELPQW- 292 Query: 246 PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 K + E+ DL+ KML Y P+ RIS + AL+H + Sbjct: 293 --------KKVSESAKDLIRKMLTYVPSMRISARDALDHEW 325 >5ZTN-A nrPDB Length = 429 Score = 128 bits (321), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 98/322 (30%), Positives = 162/322 (50%), Gaps = 46/322 (14%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP-- 61 Y ++ IG+G++G V K Q VA+K +R E+ A EI +L+ LR Sbjct: 99 YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVR---NEKRFHRQAAEEIRILEHLRKQDK 155 Query: 62 ----NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 N++ + + + + + FE LSM+L + + Q LV+ + + ILQ + Sbjct: 156 DNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKK-NKFQGFSLPLVRKFAHSILQCLD 214 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGT--IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 H R++H DLKP+N+L+ +G IK+ DFG + RVYT+ + + +YR+PEV+ Sbjct: 215 ALHKNRIIHCDLKPENILLKQQGRSGIKVIDFG--SSCYEHQRVYTY-IQSRFYRAPEVI 271 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 LG ARY P+D+WS+G I AEL T PL G+ E DQL + LG P+ ++ + + Sbjct: 272 LG-ARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAK 330 Query: 236 DYKNT--FPKW------------------KPGSL---------ASHVKNLDEN-GLDLLS 265 ++ ++ +P++ + G L + +K D+ LD L Sbjct: 331 NFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLK 390 Query: 266 KMLIYDPAKRISGKMALNHPYF 287 + L +DPA R++ AL HP+ Sbjct: 391 QCLEWDPAVRMTPGQALRHPWL 412 >6O6Q-A nrPDB Length = 335 Score = 127 bits (320), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 97/308 (31%), Positives = 165/308 (53%), Gaps = 41/308 (13%) Query: 2 EDYTKIEKIGEGTYGVVYKG-----RHKTTGQV---VAMKKIRLESEEEGVPSTAIREIS 53 E+Y + K+G G Y V+ G R K +V V KKI+ REIS Sbjct: 41 ENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKKIK-------------REIS 87 Query: 54 LLKELRH-PNIVSLQDVLM--QDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYL 109 +LK L PNI+++ DV+ Q LIFE ++ +D + S+ P + D ++ Y+ Sbjct: 88 ILKNLVDGPNIIAMLDVVREPQSKTPGLIFEHINNIDFR----SLYP-TFTDYD-IRFYM 141 Query: 110 YQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLW 168 Y++L+ + + HS ++HRD+KP N++ID DK ++L D+GLA + P Y V + + Sbjct: 142 YELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYH-PGTEYNVRVASRY 200 Query: 169 YRSPEVLLGSARYSTPVDIWSIGTIFAELA-TKKPLFHGDSEIDQLFRIFRALGTPNNEV 227 ++ PE+L+ Y +D+WS G + A + K+P FHG S DQL +I R LG+ N + Sbjct: 201 FKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKK 260 Query: 228 WPEVESL---QDYKN----TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKM 280 + E ++ ++Y++ +W ++ + + LDL+ ++L YD +R++ K Sbjct: 261 YLEKYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKE 320 Query: 281 ALNHPYFN 288 A+ H YF+ Sbjct: 321 AMKHAYFD 328 >4UZD-A nrPDB Length = 287 Score = 125 bits (313), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 83/287 (28%), Positives = 138/287 (48%), Gaps = 35/287 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELR 59 +ED+ +G+G +G VY R K + ++A+K + + + E+ GV RE+ + LR Sbjct: 7 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 66 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HPNI+ L +R+YLI E+ L + D +Y+ ++ + +C Sbjct: 67 HPNILRLYGYFHDATRVYLILEY--APLGTVYRELQKLSKFDEQRTATYITELANALSYC 124 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 HS+RV+HRD+KP+NLL+ G +K+ADFG + P T TL Y PE++ G Sbjct: 125 HSKRVIHRDIKPENLLLGSAGELKIADFGW--SVHAPSSRRTTLCGTLDYLPPEMIEGRM 182 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 + VD+WS+G + E KP F ++ + RI R + Sbjct: 183 -HDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRV------------------EF 223 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 TFP + + E DL+S++L ++P++R + L HP+ Sbjct: 224 TFPDF-----------VTEGARDLISRLLKHNPSQRPMLREVLEHPW 259 >6EII-A nrPDB Length = 352 Score = 123 bits (309), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 92/301 (30%), Positives = 159/301 (52%), Gaps = 28/301 (9%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH- 60 +DY + K+G G Y V++ + T + V +K ++ + REI +L+ LR Sbjct: 60 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGG 114 Query: 61 PNIVSLQDVLMQD-SRL-YLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 PNI++L D++ SR L+FE ++ D K+ Q + ++ Y+Y+IL+ + Sbjct: 115 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY------QTLTDYDIRFYMYEILKALD 168 Query: 118 FCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 +CHS ++HRD+KP N++ID + ++L D+GLA F P + Y V + +++ PE+L+ Sbjct: 169 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLV 227 Query: 177 GSARYSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTP---------NNE 226 Y +D+WS+G + A + +K P FHG DQL RI + LGT N E Sbjct: 228 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 287 Query: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 + P + +++ +W+ + + + LD L K+L YD R++ + A+ HPY Sbjct: 288 LDPRFNDILG-RHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 346 Query: 287 F 287 F Sbjct: 347 F 347 >4MD7-E nrPDB Length = 391 Score = 123 bits (308), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 92/301 (30%), Positives = 159/301 (52%), Gaps = 28/301 (9%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH- 60 +DY + K+G G Y V++ + T + V +K ++ + REI +L+ LR Sbjct: 37 DDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKK-----KKIKREIKILENLRGG 91 Query: 61 PNIVSLQDVLMQD-SRL-YLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 PNI++L D++ SR L+FE ++ D K+ Q + ++ Y+Y+IL+ + Sbjct: 92 PNIITLADIVKDPVSRTPALVFEHVNNTDFKQLY------QTLTDYDIRFYMYEILKALD 145 Query: 118 FCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 +CHS ++HRD+KP N++ID + ++L D+GLA F P + Y V + +++ PE+L+ Sbjct: 146 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE-FYHPGQEYNVRVASRYFKGPELLV 204 Query: 177 GSARYSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTP---------NNE 226 Y +D+WS+G + A + +K P FHG DQL RI + LGT N E Sbjct: 205 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 264 Query: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 + P + +++ +W+ + + + LD L K+L YD R++ + A+ HPY Sbjct: 265 LDPRFNDILG-RHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPY 323 Query: 287 F 287 F Sbjct: 324 F 324 >3TAC-A nrPDB Length = 361 Score = 123 bits (308), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 92/305 (30%), Positives = 145/305 (47%), Gaps = 41/305 (13%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE--SEEEGVPSTAI-REISLLKELRH 60 Y E IG+G + VV + ++ TGQ A+K + + + G+ + + RE S+ L+H Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 61 PNIVSLQDVLMQDSRLYLIFEF-----LSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 P+IV L + D LY++FEF L ++ K D+ G ++ Y+ QIL+ Sbjct: 88 PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADA---GFVYSEAVASHYMRQILEA 144 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSP 172 + +CH ++HRD+KP +L+ K +KL FG+A G V V T + +P Sbjct: 145 LRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAP 204 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 EV+ Y PVD+W G I L + F+G E R+F + Sbjct: 205 EVV-KREPYGKPVDVWGCGVILFILLSGCLPFYGTKE-----RLFEGIIK---------- 248 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 YK +W SH+ E+ DL+ +ML+ DPA+RI+ ALNHP+ + D Sbjct: 249 --GKYKMNPRQW------SHI---SESAKDLVRRMLMLDPAERITVYEALNHPWLKERDR 297 Query: 293 QIKKM 297 K+ Sbjct: 298 YAYKI 302 >5Y86-A nrPDB Length = 588 Score = 122 bits (307), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 95/323 (29%), Positives = 163/323 (50%), Gaps = 46/323 (14%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP-- 61 Y ++ IG+G++G V + Q VA+K +R E+ A EI +L+ L+ Sbjct: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR---NEKRFHRQAAEEIRILEHLKKQDK 265 Query: 62 ----NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 N++ + + + + + FE LS+DL + + Q LV+ + ILQ + Sbjct: 266 TGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNK-FQGFSVQLVRKFAQSILQSLD 324 Query: 118 FCHSRRVLHRDLKPQNLLIDDKG--TIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 H +++H DLKP+N+L+ G + K+ DFG + F ++YT+ + + +YR+PE++ Sbjct: 325 ALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQ-KLYTY-IQSRFYRAPEII 381 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 LGS RYSTP+DIWS G I AEL T +PLF G+ E DQL + LG P ++ + + + Sbjct: 382 LGS-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAK 440 Query: 236 DYKNT--FPKW-------------------------KPGS--LASHVKNLDEN-GLDLLS 265 + N+ P++ PGS + +K D+ ++ L Sbjct: 441 YFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLK 500 Query: 266 KMLIYDPAKRISGKMALNHPYFN 288 + L +DP+ R++ AL HP+ + Sbjct: 501 RCLHWDPSARLTPAQALRHPWIS 523 >3Q5I-A nrPDB Length = 504 Score = 121 bits (304), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 91/309 (29%), Positives = 138/309 (44%), Gaps = 44/309 (14%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR----------- 50 E Y K+ K+G G YG V + K A+K I+ ++G S + Sbjct: 36 ESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYN 95 Query: 51 EISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLY 110 EISLLK L HPNI+ L DV YL+ EF + + I D + + Sbjct: 96 EISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGG--ELFEQIINRHKFDECDAANIMK 153 Query: 111 QILQGIVFCHSRRVLHRDLKPQNLLIDDKGT---IKLADFGLARAFGIPIRVYTHEVVTL 167 QIL GI + H ++HRD+KP+N+L+++K + IK+ DFGL+ F ++ + T Sbjct: 154 QILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKL-RDRLGTA 212 Query: 168 WYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEV 227 +Y +PEVL +Y+ D+WS G I L P F G ++ D + ++ + Sbjct: 213 YYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKG-------- 262 Query: 228 WPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 Y F W KN+ + +L+ ML YD KR + + ALN + Sbjct: 263 --------KYYFDFNDW---------KNISDEAKELIKLMLTYDYNKRCTAEEALNSRWI 305 Query: 288 NDLDNQIKK 296 N I K Sbjct: 306 KKYANNINK 314 >3DXN-A nrPDB Length = 287 Score = 121 bits (303), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 87/294 (29%), Positives = 136/294 (46%), Gaps = 34/294 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAI-REISLLKELRHPN 62 Y +++K+G G YG V + K TG A+K I+ S S A+ E+++LK+L HPN Sbjct: 23 YQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPN 82 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 I+ L + YL+ E + D I Q + Q+L G + H Sbjct: 83 IMKLYEFFEDKRNYYLVMEVYRGG--ELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKH 140 Query: 123 RVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 ++HRDLKP+NLL++ K IK+ DFGL+ F + ++ + T +Y +PEVL Sbjct: 141 NIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKM-KERLGTAYYIAPEVL--RK 197 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 +Y D+WS G I L P F G ++ + L R+ + + + W +V Sbjct: 198 KYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQV-------- 249 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 + L+ ML Y+P+KRIS + ALNHP+ +Q Sbjct: 250 -----------------SDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKFCSQ 286 >3HZT-A nrPDB Length = 467 Score = 120 bits (302), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 86/287 (29%), Positives = 134/287 (46%), Gaps = 34/287 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAI-REISLLKELRHPN 62 Y +++K+G G YG V + K TG A+K I+ S S A+ E+++LK+L HPN Sbjct: 6 YQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPN 65 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 I+ L + YL+ E + D I Q + Q+L G + H Sbjct: 66 IMKLYEFFEDKRNYYLVMEVYRGG--ELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKH 123 Query: 123 RVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 ++HRDLKP+NLL++ K IK+ DFGL+ F + ++ + T +Y +PEVL Sbjct: 124 NIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKM-KERLGTAYYIAPEVL--RK 180 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 +Y D+WS G I L P F G ++ + L R+ + + + W +V Sbjct: 181 KYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVS------- 233 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 + L+ ML Y+P+KRIS + ALNHP+ Sbjct: 234 ------------------DEAKQLVKLMLTYEPSKRISAEEALNHPW 262 >3MN3-A nrPDB Length = 271 Score = 120 bits (302), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 87/280 (31%), Positives = 137/280 (48%), Gaps = 42/280 (15%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMK----KIRLESEEEGVPSTAIREISLLKEL 58 +Y ++ +GEG++G V H TTGQ VA+K K+ +S+ +G REIS L+ L Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQG---RIEREISYLRLL 61 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 RHP+I+ L DV+ + ++ E+ +L D I M + + QI+ + + Sbjct: 62 RHPHIIKLYDVIKSKDEIIMVIEYAGNEL---FDYIVQRDKMSEQEARRFFQQIISAVEY 118 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 CH +++HRDLKP+NLL+D+ +K+ADFGL+ + T + Y +PEV+ G Sbjct: 119 CHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKT-SCGSPNYAAPEVISGK 177 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 VD+WS G I + ++ F D I LF+ +N V+ Sbjct: 178 LYAGPEVDVWSCGVILYVMLCRRLPF-DDESIPVLFK------NISNGVY---------- 220 Query: 239 NTFPKW-KPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS 277 T PK+ PG+ L+ +MLI +P RIS Sbjct: 221 -TLPKFLSPGAAG------------LIKRMLIVNPLNRIS 247 >2PVN-A nrPDB Length = 352 Score = 119 bits (299), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 87/300 (29%), Positives = 150/300 (50%), Gaps = 26/300 (8%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +DY + K+G G Y V++G + + K I + L P Sbjct: 52 DDYEVVRKVGRGKYSEVFEGINVNNNE----KCIIKILKPVKKKKIKREIKILQNLCGGP 107 Query: 62 NIVSLQDVLM-QDSRL-YLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 NIV L D++ Q S+ LIFE+++ D K ++ ++ Y+Y++L+ + + Sbjct: 108 NIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVLYPTLTDYD------IRYYIYELLKALDY 161 Query: 119 CHSRRVLHRDLKPQNLLIDDK-GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 CHS+ ++HRD+KP N++ID + ++L D+GLA F P + Y V + +++ PE+L+ Sbjct: 162 CHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAE-FYHPGKEYNVRVASRYFKGPELLVD 220 Query: 178 SARYSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTPNNEVW-------- 228 Y +D+WS+G +FA + +K P F+G DQL +I + LGT + Sbjct: 221 LQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIEL 280 Query: 229 -PEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 P++E+L + P W A + + +D L K+L YD +R++ A+ HPYF Sbjct: 281 DPQLEALVGRHSRKP-WLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYF 339 >5U6Y-A nrPDB Length = 461 Score = 119 bits (299), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 87/288 (30%), Positives = 132/288 (45%), Gaps = 31/288 (10%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y E++G+G + VV + GQ A K I + RE + + L+HPNI Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 V L D + ++ YLIF+ ++ + + I +Y + + QIL+ ++ CH Sbjct: 62 VRLHDSISEEGHHYLIFDLVTGG--ELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 119 Query: 124 VLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 V+HRDLKP+NLL+ K +KLADFGLA + + T Y SPEVL Sbjct: 120 VVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP- 178 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 Y PVD+W+ G I L P F D + +L++ +A Y Sbjct: 179 YGKPVDLWACGVILYILLVGYPPF-WDEDQHRLYQQIKAGA---------------YDFP 222 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 P+W + DL++KML +P+KRI+ AL HP+ + Sbjct: 223 SPEW---------DTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 261 >2VZ6-A nrPDB Length = 313 Score = 119 bits (299), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 87/288 (30%), Positives = 132/288 (45%), Gaps = 31/288 (10%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y E++G+G + VV + GQ A K I + RE + + L+HPNI Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 V L D + ++ YLIF+ ++ + + I +Y + + QIL+ ++ CH Sbjct: 84 VRLHDSISEEGHHYLIFDLVTGG--ELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 141 Query: 124 VLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 V+HRDLKP+NLL+ K +KLADFGLA + + T Y SPEVL Sbjct: 142 VVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDP- 200 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 Y PVD+W+ G I L P F D + +L++ +A Y Sbjct: 201 YGKPVDLWACGVILYILLVGYPPF-WDEDQHRLYQQIKAGA---------------YDFP 244 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 P+W + DL++KML +P+KRI+ AL HP+ + Sbjct: 245 SPEW---------DTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 283 >3D2K-A nrPDB Length = 272 Score = 119 bits (298), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 80/287 (27%), Positives = 136/287 (47%), Gaps = 35/287 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELR 59 +ED+ +G+G +G VY R + + ++A+K + + + E+ GV RE+ + LR Sbjct: 11 LEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLR 70 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HPNI+ L +R+YLI E+ L + D +Y+ ++ + +C Sbjct: 71 HPNILRLYGYFHDATRVYLILEY--APLGTVYRELQKLSRFDEQRTATYITELANALSYC 128 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 HS+RV+HRD+KP+NLL+ G +K+ADFG + P T TL Y PE++ G Sbjct: 129 HSKRVIHRDIKPENLLLGSNGELKIADFGW--SVHAPSSRRTTLCGTLDYLPPEMIEGRM 186 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 + VD+WS+G + E P F + + RI R + Sbjct: 187 -HDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRV------------------EF 227 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 TFP + + E DL+S++L ++ ++R++ L HP+ Sbjct: 228 TFPDF-----------VTEGARDLISRLLKHNASQRLTLAEVLEHPW 263 >2VN9-A nrPDB Length = 301 Score = 119 bits (298), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 87/288 (30%), Positives = 133/288 (46%), Gaps = 31/288 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++Y E++G+G + VV + TGQ A K I + RE + + L+HP Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 63 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L D + ++ YL+F+ ++ + + I +Y + + QIL+ + CH Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGG--ELFEDIVAREYYSEADASHCIQQILESVNHCHL 121 Query: 122 RRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 ++HRDLKP+NLL+ K +KLADFGLA + + T Y SPEVL Sbjct: 122 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 181 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y PVD+W+ G I L P F D + +L++ +A Y Sbjct: 182 P-YGKPVDMWACGVILYILLVGYPPF-WDEDQHRLYQQIKAGA---------------YD 224 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 P+W + DL++KML +PAKRI+ AL HP+ Sbjct: 225 FPSPEW---------DTVTPEAKDLINKMLTINPAKRITASEALKHPW 263 >3KK8-A nrPDB Length = 284 Score = 119 bits (297), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 92/296 (31%), Positives = 138/296 (46%), Gaps = 42/296 (14%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++Y E++G+G + VV + HKTTG A K I + RE + ++L+HP Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHP 65 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L D + ++S YL+F+ ++ + + I ++ + + QIL+ I +CHS Sbjct: 66 NIVRLHDSIQEESFHYLVFDLVTGG--ELFEDIVAREFYSEADASHCIQQILESIAYCHS 123 Query: 122 RRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVV-----TLWYRSPE 173 ++HR+LKP+NLL+ K +KLADFGLA I V E T Y SPE Sbjct: 124 NGIVHRNLKPENLLLASKAKGAAVKLADFGLA------IEVNDSEAWHGFAGTPGYLSPE 177 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 233 VL YS PVDIW+ G I L P F D + +L+ +A Sbjct: 178 VLKKDP-YSKPVDIWACGVILYILLVGYPPF-WDEDQHRLYAQIKA-------------G 222 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 DY + P+W + L+ ML +P KRI+ AL P+ + Sbjct: 223 AYDYPS--PEW---------DTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICN 267 >6HMD-A nrPDB Length = 365 Score = 119 bits (297), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 84/301 (27%), Positives = 157/301 (52%), Gaps = 28/301 (9%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH- 60 +DY + K+G G Y V++ + T + ++ ++ + RE+ +L+ LR Sbjct: 53 DDYQLVRKLGRGKYSEVFEAINITNNE-----RVVVKILKPVKKKKIKREVKILENLRGG 107 Query: 61 PNIVSLQDVLMQ--DSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 NI+ L D + L+FE+++ D K+ Q + ++ Y+Y++L+ + Sbjct: 108 TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY------QILTDFDIRFYMYELLKALD 161 Query: 118 FCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 +CHS+ ++HRD+KP N++ID + ++L D+GLA F P + Y V + +++ PE+L+ Sbjct: 162 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGPELLV 220 Query: 177 GSARYSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTP---------NNE 226 Y +D+WS+G + A + ++ P FHG DQL RI + LGT + + Sbjct: 221 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 280 Query: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 + P + +++ +W+ + + + LDLL K+L YD +R++ K A+ HPY Sbjct: 281 LDPHFNDILG-QHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 339 Query: 287 F 287 F Sbjct: 340 F 340 >2XNP-A nrPDB Length = 279 Score = 119 bits (297), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 83/253 (32%), Positives = 124/253 (49%), Gaps = 18/253 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 EDY + IG G+YG K R K+ G+++ K++ S E + E++LL+EL+HP Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65 Query: 62 NIVSLQDVLMQ--DSRLYLIFEFL-SMDLKKYL-DSIPPGQYMDSSLVKSYLYQILQGIV 117 NIV D ++ ++ LY++ E+ DL + QY+D V + Q+ + Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125 Query: 118 FCHSRR-----VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSP 172 CH R VLHRDLKP N+ +D K +KL DFGLAR V T +Y SP Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRI----FRAL----GTPN 224 E + Y+ DIWS+G + EL P F S+ + +I FR + Sbjct: 186 EQ-MNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDEL 244 Query: 225 NEVWPEVESLQDY 237 NE+ + +L+DY Sbjct: 245 NEIITRMLNLKDY 257 >2BDW-A nrPDB Length = 362 Score = 119 bits (297), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 92/296 (31%), Positives = 138/296 (46%), Gaps = 42/296 (14%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++Y E++G+G + VV + HKTTG A K I + RE + ++L+HP Sbjct: 29 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHP 88 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L D + ++S YL+F+ ++ + + I ++ + + QIL+ I +CHS Sbjct: 89 NIVRLHDSIQEESFHYLVFDLVTGG--ELFEDIVAREFYSEADASHCIQQILESIAYCHS 146 Query: 122 RRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHE-----VVTLWYRSPE 173 ++HR+LKP+NLL+ K +KLADFGLA I V E T Y SPE Sbjct: 147 NGIVHRNLKPENLLLASKAKGAAVKLADFGLA------IEVNDSEAWHGFAGTPGYLSPE 200 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 233 VL YS PVDIW+ G I L P F D + +L+ +A Sbjct: 201 VLKKDP-YSKPVDIWACGVILYILLVGYPPF-WDEDQHRLYAQIKA-------------G 245 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 DY + P+W + L+ ML +P KRI+ AL P+ + Sbjct: 246 AYDYPS--PEW---------DTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICN 290 >6FD3-A nrPDB Length = 300 Score = 118 bits (296), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 84/284 (29%), Positives = 138/284 (48%), Gaps = 32/284 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 YT+ EKIG+G G VY TGQ VA+K++ L+ + + I EI +++E ++PNI Sbjct: 24 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK--KELIINEILVMRENKNPNI 81 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 V+ D + L+++ E+L+ L + MD + + + LQ + F HS + Sbjct: 82 VNYLDSYLVGDELWVVMEYLA---GGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQ 138 Query: 124 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYST 183 V+HRD+K N+L+ G++KL DFG + V T ++ +PEV+ A Y Sbjct: 139 VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGP 197 Query: 184 PVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPK 243 VDIWS+G + E+ +P + ++ + L+ I GTP LQ+ Sbjct: 198 KVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATN-GTP---------ELQN------- 240 Query: 244 WKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 P L++ + D L++ L D +R S K L HP+ Sbjct: 241 --PERLSAVFR-------DFLNRCLEMDVDRRGSAKELLQHPFL 275 >4D28-A nrPDB Length = 446 Score = 118 bits (296), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 73/200 (36%), Positives = 106/200 (53%), Gaps = 4/200 (2%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAI-REISLLKELRHPNIVSLQD 68 IGEGT+ V R+ TG VA+K + + + I REIS++K +RHPNIV L + Sbjct: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 VL S++Y++ EF++ + D I + + Y Q++ + CHS+ V HRD Sbjct: 77 VLASKSKIYIVLEFVTGG--ELFDRIVHKGRLKEDESRKYFQQLVDAVAHCHSKGVYHRD 134 Query: 129 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIW 188 LKP+NLL+D G +K++DFGL+ + + T Y +PEVL G + DIW Sbjct: 135 LKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGYDGSAADIW 194 Query: 189 SIGTI-FAELATKKPLFHGD 207 S G I F LA P D Sbjct: 195 SCGVILFVILAGYLPFSETD 214 >3BHH-A nrPDB Length = 295 Score = 118 bits (296), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 89/288 (30%), Positives = 134/288 (46%), Gaps = 31/288 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++Y E IG+G + VV + TG A K I + RE + + L+H Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 63 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L D + ++ YL+F+ ++ + + I +Y + + QIL+ ++ CH Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGG--ELFEDIVAREYYSEADASHCIQQILEAVLHCHQ 121 Query: 122 RRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 V+HRDLKP+NLL+ K +KLADFGLA + + T Y SPEVL Sbjct: 122 MGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKE 181 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 A Y PVDIW+ G I L P F D + +L++ +A Y Sbjct: 182 A-YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQIKAGA---------------YD 224 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 P+W ++ KN L+++ML +PAKRI+ AL HP+ Sbjct: 225 FPSPEWD--TVTPEAKN-------LINQMLTINPAKRITAHEALKHPW 263 >2V7O-A nrPDB Length = 336 Score = 118 bits (295), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 88/288 (30%), Positives = 135/288 (46%), Gaps = 31/288 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +DY E++G+G + VV + KT Q A K I + RE + + L+HP Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 90 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L D + ++ YL+F+ ++ + + I +Y + ++QIL+ + H Sbjct: 91 NIVRLHDSISEEGFHYLVFDLVTGG--ELFEDIVAREYYSEADASHCIHQILESVNHIHQ 148 Query: 122 RRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 ++HRDLKP+NLL+ K +KLADFGLA + + T Y SPEVL Sbjct: 149 HDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKD 208 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y PVDIW+ G I L P F D + +L++ +A Y Sbjct: 209 P-YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQIKAGA---------------YD 251 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 P+W ++ KN L+++ML +PAKRI+ AL HP+ Sbjct: 252 FPSPEWD--TVTPEAKN-------LINQMLTINPAKRITADQALKHPW 290 >3SOA-A nrPDB Length = 444 Score = 117 bits (294), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 86/290 (29%), Positives = 133/290 (45%), Gaps = 31/290 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E+Y E++G+G + VV + GQ A I + RE + + L+HP Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHP 70 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L D + ++ YLIF+ ++ + + I +Y + + QIL+ ++ CH Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGG--ELFEDIVAREYYSEADASHCIQQILEAVLHCHQ 128 Query: 122 RRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 V+HR+LKP+NLL+ K +KLADFGLA + + T Y SPEVL Sbjct: 129 MGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD 188 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y PVD+W+ G I L P F D + +L++ +A Y Sbjct: 189 P-YGKPVDLWACGVILYILLVGYPPF-WDEDQHRLYQQIKAGA---------------YD 231 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 P+W + DL++KML +P+KRI+ AL HP+ + Sbjct: 232 FPSPEW---------DTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272 >6CQF-A nrPDB Length = 297 Score = 117 bits (294), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 71/211 (33%), Positives = 121/211 (57%), Gaps = 17/211 (8%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + Y ++++G GTYG V+K R K +G +VA+K +++E +++ ST +EI +LK RH Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDD--VSTLQKEILILKTCRHA 73 Query: 62 NIVSLQDVLMQDSRLYLIFEFLS----MDLKKYLDSIPPGQYMDSSLVKSYLY-QILQGI 116 NIV+ + +L++ EF D+ + S+ S L SY+ ++LQG+ Sbjct: 74 NIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSL-------SELQISYVCREVLQGL 126 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 + HS++ +HRD+K N+LI+D G ++LADFG++ G + + T ++ +PEV Sbjct: 127 AYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAA 186 Query: 177 GSAR--YSTPVDIWSIGTIFAELAT-KKPLF 204 + + Y+ DIWS+G ELA + PLF Sbjct: 187 VALKGGYNELCDIWSLGITAIELAELQPPLF 217 >4RGJ-A nrPDB Length = 520 Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 90/303 (29%), Positives = 146/303 (48%), Gaps = 61/303 (20%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTG-----QVVAMKKIRLESEEEGVPSTAIREISLLK 56 E Y I+ +G+G++G V R K TG +V++ K ++ ++++E + +RE+ LLK Sbjct: 60 EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESL----LREVELLK 115 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLY------ 110 L H NI+ L + ++ YL+ D G+ D + + Y Sbjct: 116 MLDHINIMKLYEFFEDNNYYYLVS-----------DVYTGGELFDEIISRKRFYEIDAAR 164 Query: 111 ---QILQGIVFCHSRRVLHRDLKPQNLLIDDKGT----IKLADFGLARAFGIPIRVYTHE 163 QIL GI + H V+HRDLKP+N+L++ K IK+ DFGL+ F ++ + Sbjct: 165 IIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKM-KDK 223 Query: 164 VVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTP 223 + T +Y +P+VL G+ Y DIWS G I L + P F+G +E D Sbjct: 224 IGTAYYIAPDVLHGT--YDEKCDIWSCGVILYILLSGCPPFNGSNEYD------------ 269 Query: 224 NNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 + +VE+ + Y P++K + + DL+ KML+Y A RIS + AL Sbjct: 270 ---ILKKVEAGK-YTFDLPQFKK---------ISDKAKDLIKKMLMYTSAVRISARDALE 316 Query: 284 HPY 286 H + Sbjct: 317 HEW 319 >4LFI-A nrPDB Length = 374 Score = 116 bits (290), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 77/256 (30%), Positives = 136/256 (53%), Gaps = 32/256 (12%) Query: 60 HPNIVSLQDVLMQ--DSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 H NI+ L D++ L+FE++ ++D + + + ++ Y++++L+ + Sbjct: 132 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLE------IRFYMFELLKAL 185 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKG-TIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 +CHS ++HRD+KP N++ID K ++L D+GLA + + + Y V + +++ PE+L Sbjct: 186 DYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-YNVRVASRFFKGPELL 244 Query: 176 LGSARYSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 + Y +D+WS GT+ A + K+ P FHG S DQL +I + LGT + E + L Sbjct: 245 VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKY-----L 299 Query: 235 QDYKNTFPK---------WKP-----GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKM 280 Y+ T P+ KP H+ DE +DL+ +L YD +R++ K Sbjct: 300 LKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDE-IIDLIDNLLRYDHQERLTAKE 358 Query: 281 ALNHPYFNDLDNQIKK 296 A+ HP+F + QI+K Sbjct: 359 AMGHPWFAPIREQIEK 374 >4APC-A nrPDB Length = 350 Score = 116 bits (290), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 63/224 (28%), Positives = 113/224 (50%), Gaps = 3/224 (1%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ME Y +++KIGEG++G + G+ +K+I + + RE+++L ++H Sbjct: 23 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 82 Query: 61 PNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 PNIV ++ ++ LY++ ++ DL K +++ G + + QI + Sbjct: 83 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINA-QKGVLFQEDQILDWFVQICLALKHV 141 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 H R++LHRD+K QN+ + GT++L DFG+AR + + + T +Y SPE+ Sbjct: 142 HDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICENKP 201 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTP 223 Y+ DIW++G + EL T K F S + + +I P Sbjct: 202 -YNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPP 244 >5J5T-A nrPDB Length = 370 Score = 115 bits (289), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 82/288 (28%), Positives = 140/288 (48%), Gaps = 32/288 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ED+ I++IG GTYG VYK R+ TG++ A+K I+LE E+ + +EI ++K+ +HP Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDF--AVVQQEIIMMKDCKHP 61 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 NIV+ ++ +L++ EF L+ P + + V + LQG+ + H Sbjct: 62 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSR---ETLQGLYYLH 118 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 S+ +HRD+K N+L+ D G +KLADFG++ I + T ++ +PEV + Sbjct: 119 SKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERK 178 Query: 181 --YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y+ D+W++G ELA +P + LF L T +N P+++ + Sbjct: 179 GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALF-----LMTKSNFQPPKLKDKMKWS 233 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 N+F + + L +P KR + + L HP+ Sbjct: 234 NSFHHF-------------------VKMALTKNPKKRPTAEKLLQHPF 262 >4B8L-A nrPDB Length = 286 Score = 115 bits (288), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 86/292 (29%), Positives = 140/292 (47%), Gaps = 45/292 (15%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELR 59 ++D+ +G+G +G VY R K ++A+K + + + E+EGV REI + LR Sbjct: 14 IDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLR 73 Query: 60 HPNIVSLQDVLMQDSRLYLIFEF-----LSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 HPNI+ + + R+YL+ EF L +L+K+ G++ D +++ ++ Sbjct: 74 HPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKH------GRF-DEQRSATFMEELAD 126 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 + +CH R+V+HRD+KP+NLL+ KG +K+ADFG + +R T TL Y PE+ Sbjct: 127 ALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWS-VHAPSLRRRT-MCGTLDYLPPEM 184 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 + G + VD+W G + E P F S + RI Sbjct: 185 IEGKT-HDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNV--------------- 228 Query: 235 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 D K FP + L + DL+SK+L Y P +R+ K + HP+ Sbjct: 229 -DLK--FPPF-----------LSDGSKDLISKLLRYHPPQRLPLKGVMEHPW 266 >3Q53-A nrPDB Length = 306 Score = 115 bits (288), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 82/284 (28%), Positives = 137/284 (48%), Gaps = 32/284 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 YT+ EKIG+G G VY TGQ VA++++ L+ + + I EI +++E ++PNI Sbjct: 23 YTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPK--KELIINEILVMRENKNPNI 80 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 V+ D + L+++ E+L+ L + MD + + + LQ + F HS + Sbjct: 81 VNYLDSYLVGDELWVVMEYLA---GGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQ 137 Query: 124 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYST 183 V+HRD+K N+L+ G++KL DFG + V T ++ +PEV+ A Y Sbjct: 138 VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-YGP 196 Query: 184 PVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPK 243 VDIWS+G + E+ +P + ++ + L+ I GTP LQ+ Sbjct: 197 KVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATN-GTP---------ELQN------- 239 Query: 244 WKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 P L++ + D L++ L D KR S K + H + Sbjct: 240 --PEKLSAIFR-------DFLNRCLEMDVEKRGSAKELIQHQFL 274 >5IG1-A nrPDB Length = 344 Score = 115 bits (287), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 82/285 (28%), Positives = 137/285 (48%), Gaps = 32/285 (11%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 IG+G + V++ +K TG+V A+K I L+S + REI + L+H +IVS++ Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRRA 84 Query: 70 LMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDL 129 +S YL+FE++S + D I ++ + + ++QIL + CHS+ ++HRDL Sbjct: 85 FRDESHFYLVFEYVSGG--ELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHRDL 142 Query: 130 KPQNLLI---DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVD 186 KP+NLL+ D +K+ DFGLA Y T Y SPEV+ Y T VD Sbjct: 143 KPENLLLASKDPNAPVKITDFGLA-VIMEQGPTYFGFAGTPGYLSPEVIR-RVPYDTAVD 200 Query: 187 IWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP 246 +W+ G I L P F + + +++ ++++ Q Y P+W Sbjct: 201 VWACGVILYILLVGYPPFWEED---------------HQKLYAQIKNCQ-YDFPSPEWDS 244 Query: 247 GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 + A+ +L+ ML +P +R + + L HP+ D Sbjct: 245 VTTAAK---------ELIKAMLEPNPKRRPTVQELLQHPWIARRD 280 >4YNZ-A nrPDB Length = 342 Score = 115 bits (287), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 72/230 (31%), Positives = 116/230 (50%), Gaps = 4/230 (1%) Query: 6 KIEK-IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIV 64 ++EK +G+G G+V G H T Q VA+K + E E V REI++LK + HP+++ Sbjct: 13 RLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVL 72 Query: 65 SLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 124 L DV LYL+ E +S + D + + + + QI+ + FCHS + Sbjct: 73 KLHDVYENKKYLYLVLEHVSGG--ELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSI 130 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTP 184 HRDLKP+NLL+D++ I++ADFG+A + + + + Y PEV+ G Sbjct: 131 CHRDLKPENLLLDERNNIRIADFGMA-SLQVGDSLLETSCGSPHYACPEVIRGEKYDGRK 189 Query: 185 VDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 D+WS G I L F D+ L ++ R + + + P+ +SL Sbjct: 190 ADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSL 239 >3COM-A nrPDB Length = 314 Score = 114 bits (285), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 77/285 (27%), Positives = 141/285 (49%), Gaps = 32/285 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E + +EK+GEG+YG VYK HK TGQ+VA+K++ +ES+ + + I+EIS++++ P Sbjct: 29 EVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEI----IKEISIMQQCDSP 84 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 ++V +++ L+++ E+ + + + + + + L L+G+ + H Sbjct: 85 HVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRL-RNKTLTEDEIATILQSTLKGLEYLHF 143 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 R +HRD+K N+L++ +G KLADFG+A + + T ++ +PEV + Y Sbjct: 144 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV-IQEIGY 202 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 241 + DIWS+G E+A KP + ++I + IF P Sbjct: 203 NCVADIWSLGITAIEMAEGKPPY---ADIHPMRAIFMIPTNPP----------------- 242 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 P ++ L S +N D + + L+ P +R + L HP+ Sbjct: 243 PTFRKPELWS------DNFTDFVKQCLVKSPEQRATATQLLQHPF 281 >2QNJ-A nrPDB Length = 328 Score = 114 bits (285), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 70/217 (32%), Positives = 109/217 (50%), Gaps = 3/217 (1%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 +Y ++ IG+G + V RH TG+ VA+K I RE+ ++K L HPN Sbjct: 13 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPN 72 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 IV L +V+ + LYLI E+ S + D + M +S QI+ + +CH + Sbjct: 73 IVKLFEVIETEKTLYLIMEYASGG--EVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 130 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 R++HRDLK +NLL+D IK+ADFG + F + ++ T + Y +PE+ G Sbjct: 131 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTF-CGSPPYAAPELFQGKKYDG 189 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA 219 VD+WS+G I L + F G + + R+ R Sbjct: 190 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG 226 >6FDY-U nrPDB Length = 276 Score = 113 bits (283), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 84/294 (28%), Positives = 140/294 (47%), Gaps = 39/294 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKG-RHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR 59 ++ + E++G GTY VYK K T +VVA+K + +S + + EI +LK +R Sbjct: 10 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIR 69 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 HP+IV L+D +YLI EF + DL +++ + + + + + ++ Q+ + F Sbjct: 70 HPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHT---RRILPEKVARVFMQQLASALQF 126 Query: 119 CHSRRVLHRDLKPQNLLID--DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 H R + H DLKPQN+L+ +K +KLADFG A+ + L Y +PE ++ Sbjct: 127 LHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPL-YMAPE-MV 184 Query: 177 GSARYSTPVDIWSIGTIFAELATKKPLFHGD--SEIDQLFRIFRALGTPNNEVWPEVESL 234 +Y VD+WS+G I E +P F SE+++ R R + P + Sbjct: 185 CQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPL------- 237 Query: 235 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 L + DLL ++L DP++RIS + HP+ + Sbjct: 238 ---------------------LSRDCRDLLQRLLERDPSRRISFQDFFAHPWVD 270 >3H4J-B nrPDB Length = 336 Score = 113 bits (282), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 86/283 (30%), Positives = 137/283 (48%), Gaps = 36/283 (12%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPNIVSL 66 E +GEG++G V H T Q VA+K I R ++ + REIS LK LRHP+I+ L Sbjct: 15 ETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKL 74 Query: 67 QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 DV+ + + ++ E+ +L D I + M + + QI+ I +CH +++H Sbjct: 75 YDVITTPTDIVMVIEYAGGEL---FDYIVEKKRMTEDEGRRFFQQIICAIEYCHRHKIVH 131 Query: 127 RDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVD 186 RDLKP+NLL+DD +K+ADFGL+ + T + Y +PEV+ G VD Sbjct: 132 RDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKT-SCGSPNYAAPEVINGKLYAGPEVD 190 Query: 187 IWSIGTI-FAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWK 245 +WS G + + L + P D I LF+ +V V + D+ Sbjct: 191 VWSCGIVLYVMLVGRLPF--DDEFIPNLFK----------KVNSCVYVMPDF------LS 232 Query: 246 PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 PG+ + L+ +M++ DP +RI+ + P+FN Sbjct: 233 PGAQS------------LIRRMIVADPMQRITIQEIRRDPWFN 263 >5ES1-A nrPDB Length = 328 Score = 113 bits (282), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 68/217 (31%), Positives = 108/217 (49%), Gaps = 3/217 (1%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 +Y + IG+G + V RH TG+ VA+K I RE+ ++K L HPN Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPN 75 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 IV L +V+ + LYL+ E+ S + D + M ++ QI+ + +CH + Sbjct: 76 IVKLFEVIETEKTLYLVMEYASAG--EVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQK 133 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 ++HRDLK +NLL+D + IK+ADFG + F + ++ T + Y +PE+ G Sbjct: 134 NIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTF-CGSPPYAAPELFQGKKYDG 192 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA 219 VDIWS+G I L + F G + + R+ R Sbjct: 193 PEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRG 229 >4FG9-A nrPDB Length = 320 Score = 113 bits (282), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 81/280 (28%), Positives = 133/280 (47%), Gaps = 33/280 (11%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 +G G + V K T ++VA+K I E+ E G + EI++L +++HPNIV+L D+ Sbjct: 26 LGTGAFSEVILAEDKRTQKLVAIKCIAKEALE-GKEGSMENEIAVLHKIKHPNIVALDDI 84 Query: 70 LMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDL 129 LYLI + +S + D I + ++Q+L + + H ++HRDL Sbjct: 85 YESGGHLYLIMQLVSG--GELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDL 142 Query: 130 KPQNLL---IDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVD 186 KP+NLL +D+ I ++DFGL++ P V + T Y +PEV L YS VD Sbjct: 143 KPENLLYYSLDEDSKIMISDFGLSK-MEDPGSVLSTACGTPGYVAPEV-LAQKPYSKAVD 200 Query: 187 IWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP 246 WSIG I L P F+ +++ +I +A +Y+ P W Sbjct: 201 CWSIGVIAYILLCGYPPFYDENDAKLFEQILKA----------------EYEFDSPYW-- 242 Query: 247 GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 ++ ++ D + ++ DP KR + + AL HP+ Sbjct: 243 -------DDISDSAKDFIRHLMEKDPEKRFTCEQALQHPW 275 >5FG8-A nrPDB Length = 285 Score = 112 bits (281), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 86/288 (29%), Positives = 136/288 (47%), Gaps = 31/288 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++Y E++G+G + +V + K+TG A K I + RE + ++L HP Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHP 73 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L D + +++ YL+F+ ++ + + I ++ + + QIL+ + CH Sbjct: 74 NIVRLHDSIQEENYHYLVFDLVTGG--ELFEDIVAREFYSEADASHCIQQILESVNHCHQ 131 Query: 122 RRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 V+HRDLKP+NLL+ K +KLADFGLA + + T Y SPEVL Sbjct: 132 NGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKE 191 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y VDIW+ G I L P F D + +L+ +A DY Sbjct: 192 P-YGKSVDIWACGVILYILLVGYPPF-WDEDQHRLYSQIKA-------------GAYDYP 236 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 + P+W ++ KN L+++ML +P KRI+ AL HP+ Sbjct: 237 S--PEWD--TVTPEAKN-------LINQMLTVNPNKRITAAEALKHPW 273 >2BRG-A nrPDB Length = 297 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 79/280 (28%), Positives = 135/280 (48%), Gaps = 33/280 (11%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 +ED+ ++ +GEG YG V ++ T + VA+K + ++ + P +EI + K L H Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVD-CPENIKKEICINKMLNH 64 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 N+V + + YL E+ S + D I P M + + +Q++ G+V+ H Sbjct: 65 ENVVKFYGHRREGNIQYLFLEYCSGG--ELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH 122 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVLLGS 178 + HRD+KP+NLL+D++ +K++DFGLA F R+ TL Y +PE+L Sbjct: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 ++ PVD+WS G + + G+ DQ +S Q+Y Sbjct: 183 EFHAEPVDVWSCGIVLTA------MLAGELPWDQ-----------------PSDSCQEYS 219 Query: 239 NTFPKWKP-GSLASHVKNLDENGLDLLSKMLIYDPAKRIS 277 + WK + + K +D L LL K+L+ +P+ RI+ Sbjct: 220 D----WKEKKTYLNPWKKIDSAPLALLHKILVENPSARIT 255 >4QMW-A nrPDB Length = 310 Score = 112 bits (281), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 72/201 (35%), Positives = 118/201 (58%), Gaps = 5/201 (2%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E +TK+EKIG+G++G V+KG T +VVA+K I LE E+ + +EI++L + P Sbjct: 29 ELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQ-QEITVLSQCDSP 87 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 + ++D++L++I E+L LD + PG +D + + + L +IL+G+ + HS Sbjct: 88 YVTKYYGSYLKDTKLWIIMEYLGGG--SALDLLEPGP-LDETQIATILREILKGLDYLHS 144 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 + +HRD+K N+L+ + G +KLADFG+A V T ++ +PEV+ SA Y Sbjct: 145 EKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSA-Y 203 Query: 182 STPVDIWSIGTIFAELATKKP 202 + DIWS+G ELA +P Sbjct: 204 DSKADIWSLGITAIELARGEP 224 >4CZT-A nrPDB Length = 464 Score = 111 bits (278), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 70/218 (32%), Positives = 116/218 (53%), Gaps = 15/218 (6%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESE-EEGVPSTAIREISLLKELRHPNIVSLQD 68 +GEGT+ V R+ G VA+K I E + + + REIS +K ++HPN++ + + Sbjct: 19 LGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFE 78 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 V+ +++Y + EF++ + D I + + Y Q++ + +CHSR V HRD Sbjct: 79 VMASKTKIYFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRD 136 Query: 129 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-----TLWYRSPEVLLGSARYST 183 LKP+NLL+D G +K++DFGL+ +P +V ++ T Y +PEV+ Sbjct: 137 LKPENLLLDANGALKVSDFGLS---ALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGA 193 Query: 184 PVDIWSIGTI-FAELATKKPLFHGDSEIDQLF-RIFRA 219 D+WS G I F +A P DS + L+ +IF+A Sbjct: 194 KADLWSCGVILFVLMAGYLPF--EDSNLTSLYKKIFKA 229 >2Y7J-A nrPDB Length = 365 Score = 111 bits (278), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 84/298 (28%), Positives = 136/298 (45%), Gaps = 40/298 (13%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEE------EGVPSTAIREISLL 55 + Y + IG G VV + H+ TG A+K + + +E E V RE +L Sbjct: 94 QKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHIL 153 Query: 56 KELR-HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 +++ HP+I++L D S ++L+F+ M + D + + +S + +L+ Sbjct: 154 RQVAGHPHIITLIDSYESSSFMFLVFDL--MRKGELFDYLTEKVALSEKETRSIMRSLLE 211 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 + F H+ ++HRDLKP+N+L+DD I+L+DFG + P T Y +PE+ Sbjct: 212 AVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLE-PGEKLRELCGTPGYLAPEI 270 Query: 175 LLGSARYSTP-----VDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 L S + P VD+W+ G I L P F +I L I Sbjct: 271 LKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEG---------- 320 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 Y+ + P+W S S VK DL+S++L DP R++ + AL HP+F Sbjct: 321 ------QYQFSSPEWDDRS--STVK-------DLISRLLQVDPEARLTAEQALQHPFF 363 >2WO6-A nrPDB Length = 382 Score = 111 bits (277), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 93/330 (28%), Positives = 155/330 (46%), Gaps = 49/330 (14%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLK---- 56 M+ Y IG+G++G V K + + VA+K I+ + +R + L+ Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDT 112 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 E+++ IV L+ M + L L+FE LS +L L + + + +L + + Q+ + Sbjct: 113 EMKY-YIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTN-FRGVSLNLTRKFAQQMCTAL 170 Query: 117 VFCHSRR--VLHRDLKPQNLLIDD--KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSP 172 +F + ++H DLKP+N+L+ + + IK+ DFG + G R+Y + + + +YRSP Sbjct: 171 LFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ--RIYQY-IQSRFYRSP 227 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 EVLLG Y +D+WS+G I E+ T +PLF G +E+DQ+ +I LG P + + Sbjct: 228 EVLLGMP-YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAP 286 Query: 233 SLQDYKNTFP--KWK-------------PGSLASHV-----------KNLDENG------ 260 + + P W PG+ H + E+G Sbjct: 287 KARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADY 346 Query: 261 ---LDLLSKMLIYDPAKRISGKMALNHPYF 287 DL+ +ML YDP RI AL H +F Sbjct: 347 LKFKDLILRMLDYDPKTRIQPYYALQHSFF 376 >4WNO-A nrPDB Length = 287 Score = 111 bits (277), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 74/226 (32%), Positives = 121/226 (53%), Gaps = 19/226 (8%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQV-VAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++++ + IG G + VV+KGRH+ + VA+K I ++ + + +EI +LKEL+H Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKS-QTLLGKEIKILKELKHE 77 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 NIV+L D + +YL+ E+ + DL YL ++ + + ++ +L QI + H Sbjct: 78 NIVALYDFQEMANSVYLVMEYCNGGDLADYLHAM---RTLSEDTIRLFLQQIAGAMRLLH 134 Query: 121 SRRVLHRDLKPQNLLIDDKGT---------IKLADFGLARAFGIPIRVYTHEVVTLWYRS 171 S+ ++HRDLKPQN+L+ + +K+ADFG AR + T + Y + Sbjct: 135 SKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT-LCGSPMYMA 193 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIF 217 PEV++ S Y D+WSIGTI + T K F S D R+F Sbjct: 194 PEVIM-SQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD--LRLF 236 >2WQN-A nrPDB Length = 310 Score = 110 bits (276), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 66/203 (32%), Positives = 104/203 (51%), Gaps = 4/203 (1%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRL-ESEEEGVPSTAIREISLLKELRHPNIVSL 66 +KIG G + VY+ G VA+KK+++ + + + I+EI LLK+L HPN++ Sbjct: 38 KKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKY 97 Query: 67 QDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYM-DSSLVKSYLYQILQGIVFCHSRRV 124 ++D+ L ++ E DL + + + + V Y Q+ + HSRRV Sbjct: 98 YASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRV 157 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTP 184 +HRD+KP N+ I G +KL D GL R F V T +Y SPE + + Y+ Sbjct: 158 MHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENG-YNFK 216 Query: 185 VDIWSIGTIFAELATKKPLFHGD 207 DIWS+G + E+A + F+GD Sbjct: 217 SDIWSLGCLLYEMAALQSPFYGD 239 >2J90-A nrPDB Length = 304 Score = 110 bits (275), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 84/295 (28%), Positives = 143/295 (48%), Gaps = 38/295 (12%) Query: 1 MEDYTKI-EKIGEGTYGVVYKGRHKTTGQVVA---MKKIRLESEEEGVPSTAI-REISLL 55 +ED+ ++ E++G G + +V K R K TG+ A +KK RL S GV I RE+++L Sbjct: 24 VEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNIL 83 Query: 56 KELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 +E+RHPNI++L D+ + + LI E +S + D + + + +L QIL G Sbjct: 84 REIRHPNIITLHDIFENKTDVVLILELVSGG--ELFDFLAEKESLTEDEATQFLKQILDG 141 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGT----IKLADFGLARAFGIPIRVYTHEVVTLWYRS 171 + + HS+R+ H DLKP+N+++ DK IKL DFG+A + + T + + Sbjct: 142 VHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAG-NEFKNIFGTPEFVA 200 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PE+ + D+WSIG I L + F G+++ + L I A+ +E Sbjct: 201 PEI-VNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNI-SAVNYDFDE----- 253 Query: 232 ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 + N E D + ++L+ DP +R++ +L H + Sbjct: 254 -------------------EYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSW 289 >2YCR-A nrPDB Length = 323 Score = 110 bits (274), Expect = 9e-25, Method: Compositional matrix adjust. Identities = 86/306 (28%), Positives = 142/306 (46%), Gaps = 41/306 (13%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMK-----KIRLESEEEGVPSTAIR-EISLL 55 ++Y + +G G G V + T + VA+K K + S E P+ + EI +L Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 56 KELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 K+L HP I+ +++ + Y++ E M+ + D + + + + K Y YQ+L Sbjct: 70 KKLNHPCIIKIKNFFDAED-YYIVLEL--MEGGELFDKVVGNKRLKEATCKLYFYQMLLA 126 Query: 116 IVFCHSRRVLHRDLKPQNLLI---DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSP 172 + + H ++HRDLKP+N+L+ ++ IK+ DFG ++ G + T T Y +P Sbjct: 127 VQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTL-CGTPTYLAP 185 Query: 173 EVL--LGSARYSTPVDIWSIGTI-FAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 EVL +G+A Y+ VD WS+G I F L+ P +++ +I EVW Sbjct: 186 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 245 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 EV E LDL+ K+L+ DP R + + AL HP+ D Sbjct: 246 EV-------------------------SEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 280 Query: 290 LDNQIK 295 D + K Sbjct: 281 EDMKRK 286 >5KZ7-A nrPDB Length = 346 Score = 110 bits (274), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 67/217 (30%), Positives = 107/217 (49%), Gaps = 3/217 (1%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 +Y ++ IG+G + V RH TG+ VA+K I RE+ ++K L HPN Sbjct: 34 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN 93 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 IV L +V+ + LYL+ E+ S + D + M ++ QI+ + +CH + Sbjct: 94 IVKLFEVIETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 151 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 ++HRDLK +NLL+D IK+ADFG + F ++ T + Y +PE+ G Sbjct: 152 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTF-CGSPPYAAPELFQGKKYDG 210 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA 219 VD+WS+G I L + F G + + R+ R Sbjct: 211 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG 247 >6QAU-A nrPDB Length = 280 Score = 110 bits (274), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 77/236 (32%), Positives = 123/236 (52%), Gaps = 39/236 (16%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKT-TGQVVAMKKIRLESEEEGVPSTAI---REISLLKEL 58 +Y+K + +G G + VV++GRH+ T VA+K I ++ + + I +EI +LKEL Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSI----NKKNLSKSQILLGKEIKILKEL 67 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 +H NIV+L DV + ++L+ E+ + DL YL + + ++ +L+QI + Sbjct: 68 QHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQA---KGTLSEDTIRVFLHQIAAAMR 124 Query: 118 FCHSRRVLHRDLKPQNLLIDDKG---------TIKLADFGLARAFGIPIRVYTHEVV--- 165 HS+ ++HRDLKPQN+L+ IK+ADFG AR Y H + Sbjct: 125 ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFAR--------YLHSNMMAA 176 Query: 166 ----TLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIF 217 + Y +PEV++ S Y D+WSIGT+ + KP F +S D R+F Sbjct: 177 DLCGSPMYMAPEVIM-SQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD--LRMF 229 >5XZW-A nrPDB Length = 471 Score = 110 bits (274), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 93/311 (29%), Positives = 145/311 (46%), Gaps = 52/311 (16%) Query: 1 MEDYTKI-EKIGEGTYGVVYKGRHKTTGQVVAMK---KIRLESEEEGVPSTAIREISLLK 56 +D++ I E +G+G + V K +TTG+ A+K K ++ +GV RE+ +L+ Sbjct: 194 FKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVT----RELEVLQ 249 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 +L HP IV L+ Y++ EF+S DL +D + + + QIL Sbjct: 250 KLNHPRIVRLKGFYEDTESYYMVMEFVSGGDL---MDFVAAHGAVGEDAGREISRQILTA 306 Query: 116 IVFCHSRRVLHRDLKPQNLLI--DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 173 I + HS + HRDLKP N+LI DD +K+ DFGLA+ G + T TL Y +PE Sbjct: 307 IKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTF-CGTLAYVAPE 365 Query: 174 VLLGS------------ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG 221 V+ G YS+ VD+WS+G + + T F G ++ DQL ++ +G Sbjct: 366 VIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQL---YKQIG 421 Query: 222 TPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 + P L+D++ + E D + +L DP R + A Sbjct: 422 RGSYHEGP----LKDFR-----------------ISEEARDFIDSLLQVDPNNRSTAAKA 460 Query: 282 LNHPYFNDLDN 292 LNHP+ D N Sbjct: 461 LNHPWIVDSSN 471 >4EQM-A nrPDB Length = 294 Score = 109 bits (273), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 74/212 (34%), Positives = 115/212 (54%), Gaps = 7/212 (3%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE-SEEEGVPSTAIREISLLKELRH 60 E Y ++K+G G VY VA+K I + E+E RE+ +L H Sbjct: 11 ERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSH 70 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 NIVS+ DV +D YL+ E++ L +Y++S P +D+++ ++ QIL GI Sbjct: 71 QNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGPLS-VDTAI--NFTNQILDGIKHA 127 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEVLLGS 178 H R++HRD+KPQN+LID T+K+ DFG+A+A T+ V+ T+ Y SPE G Sbjct: 128 HDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKGE 187 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEI 210 A DI+SIG + E+ +P F+G++ + Sbjct: 188 AT-DECTDIYSIGIVLYEMLVGEPPFNGETAV 218 >4YZB-A nrPDB Length = 491 Score = 109 bits (273), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 89/288 (30%), Positives = 140/288 (48%), Gaps = 38/288 (13%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 +G+G++G V + K TGQ A+K I + + +++ ++E+ LLK+L HPNI+ L + Sbjct: 38 LGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYE 97 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 YL+ E + + D I + + Q+L GI + H +++HRD Sbjct: 98 FFEDKGYFYLVTEVYTGG--ELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRD 155 Query: 129 LKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPV 185 LKP+NLL+++K I++ DFGL+ F + ++ T +Y +PEVL G+ Y Sbjct: 156 LKPENLLLENKRKDANIRIIDFGLSTHFE-STKKMKDKIGTAYYIAPEVLHGT--YDEKC 212 Query: 186 DIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF--PK 243 D+WS G I L + P F+G +E D L ++ + K TF P+ Sbjct: 213 DVWSTGVILYILLSGCPPFNGANEFDILKKVEKG------------------KFTFDLPQ 254 Query: 244 WKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 WK S E DL+ KML Y P RIS + AL H + D Sbjct: 255 WKKVS---------EPAKDLIRKMLAYVPTMRISARDALEHEWLKTTD 293 >4LG4-A nrPDB Length = 299 Score = 109 bits (272), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 75/288 (26%), Positives = 142/288 (49%), Gaps = 32/288 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E + +EK+GEG+YG V+K HK +GQVVA+K++ +ES+ + + I+EIS++++ P Sbjct: 11 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEI----IKEISIMQQCDSP 66 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +V +++ L+++ E+ + + ++ + + L L+G+ + H Sbjct: 67 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDE-IATILKSTLKGLEYLHF 125 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 R +HR++K N+L++ +G KLADFG+A + + T ++ +PEV + Y Sbjct: 126 MRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV-IQEIGY 184 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 241 + DIWS+G E+A KP + ++I + IF P Sbjct: 185 NCVADIWSLGITSIEMAEGKPPY---ADIHPMRAIFMIPTNPP----------------- 224 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 P ++ L S ++ D + K L+ +P +R + L HP+ + Sbjct: 225 PTFRKPELWS------DDFTDFVKKCLVKNPEQRATATQLLQHPFIKN 266 >3I6U-A nrPDB Length = 419 Score = 108 bits (271), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 85/306 (27%), Positives = 142/306 (46%), Gaps = 41/306 (13%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMK-----KIRLESEEEGVPSTAIR-EISLL 55 ++Y + +G G G V + T + VA++ K + S E P+ + EI +L Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 56 KELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 K+L HP I+ +++ + Y++ E M+ + D + + + + K Y YQ+L Sbjct: 195 KKLNHPCIIKIKNFFDAED-YYIVLEL--MEGGELFDKVVGNKRLKEATCKLYFYQMLLA 251 Query: 116 IVFCHSRRVLHRDLKPQNLLI---DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSP 172 + + H ++HRDLKP+N+L+ ++ IK+ DFG ++ G + T T Y +P Sbjct: 252 VQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTL-CGTPTYLAP 310 Query: 173 EVL--LGSARYSTPVDIWSIGTI-FAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 EVL +G+A Y+ VD WS+G I F L+ P +++ +I EVW Sbjct: 311 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 370 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 EV E LDL+ K+L+ DP R + + AL HP+ D Sbjct: 371 EV-------------------------SEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 405 Query: 290 LDNQIK 295 D + K Sbjct: 406 EDMKRK 411 >5WAX-A nrPDB Length = 310 Score = 108 bits (271), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 84/288 (29%), Positives = 136/288 (47%), Gaps = 35/288 (12%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPN 62 Y + IG G +GV R++ GQ+VA+K I R E +E V REI + LRHPN Sbjct: 13 YELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQ----REIINHRSLRHPN 68 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 I+ ++V++ + L ++ E+ S + + I + + Q++ G+ +CHS Sbjct: 69 IIRFKEVILTPTHLAIVMEYASG--GELFERICNAGRFSEDEARFFFQQLISGVSYCHSM 126 Query: 123 RVLHRDLKPQNLLIDDKGT--IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 +V HRDLK +N L+D +K+ DFG +++ + + + V T Y +PEVLL Sbjct: 127 QVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKS-TVGTPAYIAPEVLLKKEY 185 Query: 181 YSTPVDIWSIG-TIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 D+WS G T++ L P D + I R LG S+ DY + Sbjct: 186 DGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQY--------SIPDYVH 237 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 P+ + DL+S++ + +PA RI+ NHP+F Sbjct: 238 ISPECQ----------------DLISRIFVANPATRITIPEIRNHPWF 269 >6AO5-A nrPDB Length = 362 Score = 108 bits (271), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 75/288 (26%), Positives = 142/288 (49%), Gaps = 32/288 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E + +EK+GEG+YG V+K HK +GQVVA+K++ +ES+ + + I+EIS++++ P Sbjct: 10 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEI----IKEISIMQQCDSP 65 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +V +++ L+++ E+ + + ++ + + L L+G+ + H Sbjct: 66 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDE-IATILKSTLKGLEYLHF 124 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 R +HR++K N+L++ +G KLADFG+A + + T ++ +PEV + Y Sbjct: 125 MRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEV-IQEIGY 183 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 241 + DIWS+G E+A KP + ++I + IF P Sbjct: 184 NCVADIWSLGITSIEMAEGKPPY---ADIHPMRAIFMIPTNPP----------------- 223 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 P ++ L S ++ D + K L+ +P +R + L HP+ + Sbjct: 224 PTFRKPELWS------DDFTDFVKKCLVKNPEQRATATQLLQHPFIKN 265 >3GUB-A nrPDB Length = 295 Score = 108 bits (271), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 89/300 (29%), Positives = 145/300 (48%), Gaps = 41/300 (13%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVA---MKKIRLESEEEGVPSTAI-REISLLKELR 59 Y E++G G + VV K R K+TG A +KK R +S GV I RE+S+LKE++ Sbjct: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HPN+++L +V + + LI E ++ + D + + + +L QIL G+ + Sbjct: 73 HPNVITLHEVYENKTDVILIGELVAGG--ELFDFLAEKESLTEEEATEFLKQILNGVYYL 130 Query: 120 HSRRVLHRDLKPQNLLIDDKGT----IKLADFGLARA--FGIPIRVYTHEVVTLWYRSPE 173 HS ++ H DLKP+N+++ D+ IK+ DFGLA FG + + T + +PE Sbjct: 131 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFG---NEFKNIFGTPEFVAPE 187 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 233 + + D+WSIG I L + F GD++ + L + N E E Sbjct: 188 I-VNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANV----SAVNYEFEDEY-- 240 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 + NT +LA D + ++L+ DP KR++ + +L HP+ D Q Sbjct: 241 ---FSNT------SALAK----------DFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQ 281 >4CQG-A nrPDB Length = 331 Score = 108 bits (270), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 82/284 (28%), Positives = 124/284 (43%), Gaps = 33/284 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y E IG G + V H TG++VA+K + + +P EI LK LRH +I Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKT-EIDALKSLRHQHI 69 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 L VL ++++++ E+ + D I + + QIL + + HS+ Sbjct: 70 CQLYHVLETKNKIFMVLEYCPGG--ELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQG 127 Query: 124 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEVLLGSARYS 182 HRDLKP+NLL D+ +KL DFGL + E +L Y +PE++ G + Sbjct: 128 YAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYLG 187 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 + D+WS+G + L F D+ + +I R K P Sbjct: 188 SEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRG------------------KYEVP 229 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 KW L + + LL +ML DP KRIS + LNHP+ Sbjct: 230 KW-----------LSPSSILLLQQMLQVDPKKRISMRNLLNHPW 262 >4RED-A nrPDB Length = 351 Score = 108 bits (270), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 87/282 (30%), Positives = 129/282 (45%), Gaps = 35/282 (12%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPNIVSL 66 + +G GT+G V G+H+ TG VA+K + R + V REI LK RHP+I+ L Sbjct: 20 DTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKL 79 Query: 67 QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 V+ S ++++ E++S + D I +D + QIL G+ +CH V+H Sbjct: 80 YQVISTPSDIFMVMEYVSG--GELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVH 137 Query: 127 RDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVD 186 RDLKP+N+L+D K+ADFGL+ + T + Y +PEV+ G VD Sbjct: 138 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT-SCGSPNYAAPEVISGRLYAGPEVD 196 Query: 187 IWSIGTI-FAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWK 245 IWS G I +A L P D + LF+ + D P++ Sbjct: 197 IWSSGVILYALLCGTLPF--DDDHVPTLFK-----------------KICDGIFYTPQY- 236 Query: 246 PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 L+ + + LL ML DP KR S K H +F Sbjct: 237 ----------LNPSVISLLKHMLQVDPMKRASIKDIREHEWF 268 >2YAB-A nrPDB Length = 361 Score = 108 bits (270), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 84/302 (27%), Positives = 144/302 (47%), Gaps = 38/302 (12%) Query: 1 MEDYTKI-EKIGEGTYGVVYKGRHKTTGQVVA---MKKIRLESEEEGVPSTAI-REISLL 55 +ED+ I E++G G + +V K R K+TG A +KK + + GV I RE+S+L Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSIL 69 Query: 56 KELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 +++ HPNI++L DV + + LI E +S + D + + + S++ QIL G Sbjct: 70 RQVLHPNIITLHDVYENRTDVVLILELVSGG--ELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGT----IKLADFGLARAFGIPIRVYTHEVVTLWYRS 171 + + H++++ H DLKP+N+++ DK IKL DFGLA + + + T + + Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVA 186 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PE+ + D+WSIG I L + F GD++ + L I + E + + Sbjct: 187 PEI-VNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQT 245 Query: 232 ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 L D + K+L+ + KR++ + AL HP+ +D Sbjct: 246 SEL-------------------------AKDFIRKLLVKETRKRLTIQEALRHPWITPVD 280 Query: 292 NQ 293 Q Sbjct: 281 TQ 282 >2HAK-A nrPDB Length = 328 Score = 108 bits (270), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 67/217 (30%), Positives = 107/217 (49%), Gaps = 3/217 (1%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 +Y + IG+G + V RH TG+ VA+K I RE+ ++K L HPN Sbjct: 16 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 75 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 IV L +V+ + LYL+ E+ S + D + M ++ QI+ + +CH + Sbjct: 76 IVKLFEVIETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 133 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 ++HRDLK +NLL+D IK+ADFG + F + ++ T + Y +PE+ G Sbjct: 134 YIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTF-CGSPPYAAPELFQGKKYDG 192 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA 219 VD+WS+G I L + F G + + R+ R Sbjct: 193 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG 229 >6HXF-B nrPDB Length = 302 Score = 108 bits (269), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 70/233 (30%), Positives = 118/233 (50%), Gaps = 29/233 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E + + ++G+G +G VYK ++K TG + A K I +SEEE I EI +L HP Sbjct: 19 EVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEEL--EDYIVEIEILATCDHP 76 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSL-----------VKSYLY 110 IV L D +L+++ EF PG +D+ + ++ Sbjct: 77 YIVKLLGAYYHDGKLWIMIEFC------------PGGAVDAIMLELDRGLTEPQIQVVCR 124 Query: 111 QILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYR 170 Q+L+ + F HS+R++HRDLK N+L+ +G I+LADFG++ ++ + T ++ Sbjct: 125 QMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWM 184 Query: 171 SPEVLLGSARYSTP----VDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA 219 +PEV++ TP DIWS+G E+A +P H + + L +I ++ Sbjct: 185 APEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKS 237 >2JC6-A nrPDB Length = 334 Score = 108 bits (269), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 82/292 (28%), Positives = 140/292 (47%), Gaps = 37/292 (12%) Query: 2 EDYTKI----EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKE 57 ED KI E +G G + V K TG++ A+K I ++ + G S+ EI++L++ Sbjct: 18 EDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK-GKESSIENEIAVLRK 76 Query: 58 LRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 ++H NIV+L+D+ + LYL+ + +S + D I + + + Q+L + Sbjct: 77 IKHENIVALEDIYESPNHLYLVMQLVSGG--ELFDRIVEKGFYTEKDASTLIRQVLDAVY 134 Query: 118 FCHSRRVLHRDLKPQNLLI---DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 + H ++HRDLKP+NLL D++ I ++DFGL++ G V + T Y +PEV Sbjct: 135 YLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEG-KGDVMSTACGTPGYVAPEV 193 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 L YS VD WSIG I L P F+ +++ +I +A Sbjct: 194 -LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKA--------------- 237 Query: 235 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 +Y+ P W ++ ++ D + ++ DP KR + + A HP+ Sbjct: 238 -EYEFDSPYW---------DDISDSAKDFIRNLMEKDPNKRYTCEQAARHPW 279 >2XIK-A nrPDB Length = 294 Score = 108 bits (269), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 71/201 (35%), Positives = 117/201 (58%), Gaps = 5/201 (2%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E +TK+++IG+G++G VYKG T +VVA+K I LE E+ + +EI++L + P Sbjct: 19 ELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQ-QEITVLSQCDSP 77 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 I ++ ++L++I E+L LD + PG ++ + + + L +IL+G+ + HS Sbjct: 78 YITRYFGSYLKSTKLWIIMEYLGGG--SALDLLKPGP-LEETYIATILREILKGLDYLHS 134 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 R +HRD+K N+L+ ++G +KLADFG+A V T ++ +PEV+ SA Y Sbjct: 135 ERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSA-Y 193 Query: 182 STPVDIWSIGTIFAELATKKP 202 DIWS+G ELA +P Sbjct: 194 DFKADIWSLGITAIELAKGEP 214 >4JXF-A nrPDB Length = 266 Score = 107 bits (268), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 80/291 (27%), Positives = 142/291 (48%), Gaps = 36/291 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESE-EEGVPSTAIREISLLKELR 59 +ED+ +G+G++ VY+ TG VA+K I ++ + G+ E+ + +L+ Sbjct: 6 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 65 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYL-DSIPPGQYMDSSLVKSYLYQILQGIV 117 HP+I+ L + + +YL+ E + ++ +YL + + P + + +++QI+ G++ Sbjct: 66 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKP---FSENEARHFMHQIITGML 122 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 + HS +LHRDL NLL+ IK+ADFGLA +P + T Y SPE+ Sbjct: 123 YLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATR 182 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 SA + D+WS+G +F L +P F D+ + L ++ L DY Sbjct: 183 SA-HGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV----------------LADY 225 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 + P L+ K DL+ ++L +PA R+S L+HP+ + Sbjct: 226 E------MPSFLSIEAK-------DLIHQLLRRNPADRLSLSSVLDHPFMS 263 >4D2V-A nrPDB Length = 356 Score = 107 bits (268), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 85/295 (28%), Positives = 129/295 (43%), Gaps = 40/295 (13%) Query: 1 MEDYTKI-------EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREIS 53 M+DY ++ E IG G + V H TG++VA+K + + +P EI Sbjct: 21 MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKT-EIE 79 Query: 54 LLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQIL 113 LK LRH +I L VL ++++++ E+ + D I + + QI+ Sbjct: 80 ALKNLRHQHICQLYHVLETANKIFMVLEYCPGG--ELFDYIISQDRLSEEETRVVFRQIV 137 Query: 114 QGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGL-ARAFGIPIRVYTHEVVTLWYRSP 172 + + HS+ HRDLKP+NLL D+ +KL DFGL A+ G L Y +P Sbjct: 138 SAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAP 197 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 E++ G + + D+WS+G + L F D+ + +I R Sbjct: 198 ELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRG------------- 244 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 K PKW L + + LL +ML DP KRIS K LNHP+ Sbjct: 245 -----KYDVPKW-----------LSPSSILLLQQMLQVDPKKRISMKNLLNHPWI 283 >1ZWS-A nrPDB Length = 288 Score = 107 bits (267), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 86/302 (28%), Positives = 146/302 (48%), Gaps = 38/302 (12%) Query: 1 MEDYTKI-EKIGEGTYGVVYKGRHKTTGQVVA---MKKIRLESEEEGVPSTAI-REISLL 55 +ED+ I E++G G + +V K R K+TG A +KK + + GV I RE+S+L Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSIL 69 Query: 56 KELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 +++ H N+++L DV + + LI E +S + D + + + S++ QIL G Sbjct: 70 RQVLHHNVITLHDVYENRTDVVLILELVSGG--ELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGT----IKLADFGLARAFGIPIRVYTHEVVTLWYRS 171 + + H++++ H DLKP+N+++ DK IKL DFGLA + + + T + + Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVA 186 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PE+ + D+WSIG I L + F GD++ + L I Sbjct: 187 PEI-VNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANI--------------T 231 Query: 232 ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 D+ F SH L + D + K+L+ + KR++ + AL HP+ +D Sbjct: 232 SVSYDFDEEF--------FSHTSELAK---DFIRKLLVKETRKRLTIQEALRHPWITPVD 280 Query: 292 NQ 293 NQ Sbjct: 281 NQ 282 >1U5R-A nrPDB Length = 348 Score = 107 bits (266), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 63/217 (29%), Positives = 113/217 (52%), Gaps = 11/217 (5%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVP-STAIREISLLKELRHPN 62 ++ + +IG G++G VY R +VVA+KK+ ++ I+E+ L++LRHPN Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLD-SIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 + + +++ +L+ E+ L+ P Q ++ + + + LQG+ + HS Sbjct: 116 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVE---IAAVTHGALQGLAYLHS 172 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG--SA 179 ++HRD+K N+L+ + G +KL DFG A P + V T ++ +PEV+L Sbjct: 173 HNMIHRDVKAGNILLSEPGLVKLGDFGSASIMA-PANSF---VGTPYWMAPEVILAMDEG 228 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRI 216 +Y VD+WS+G ELA +KP + + L+ I Sbjct: 229 QYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHI 265 >2W4O-A nrPDB Length = 349 Score = 107 bits (266), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 89/315 (28%), Positives = 148/315 (46%), Gaps = 57/315 (18%) Query: 1 MEDYTKIE-KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR 59 + D+ ++E ++G G +VY+ + K T + A+K ++ +++ V + EI +L L Sbjct: 51 LSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRT----EIGVLLRLS 106 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HPNI+ L+++ + + L+ E ++ + D I Y + QIL+ + + Sbjct: 107 HPNIIKLKEIFETPTEISLVLELVTGG--ELFDRIVEKGYYSERDAADAVKQILEAVAYL 164 Query: 120 HSRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAFGIPIRVYTHEVV------TLWYR 170 H ++HRDLKP+NLL +K+ADFGL+ ++ H+V+ T Y Sbjct: 165 HENGIVHRDLKPENLLYATPAPDAPLKIADFGLS-------KIVEHQVLMKTVCGTPGYC 217 Query: 171 SPEVLLGSARYSTPVDIWSIGTI-FAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 +PE+L G A Y VD+WS+G I + L +P + D DQ F R L Sbjct: 218 APEILRGCA-YGPEVDMWSVGIITYILLCGFEPFY--DERGDQ-FMFRRILNC------- 266 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY--- 286 +Y P W SL N DL+ K+++ DP KR++ AL HP+ Sbjct: 267 ------EYYFISPWWDEVSL---------NAKDLVRKLIVLDPKKRLTTFQALQHPWVTG 311 Query: 287 ----FNDLDNQIKKM 297 F +D KK+ Sbjct: 312 KAANFVHMDTAQKKL 326 >4REW-A nrPDB Length = 540 Score = 107 bits (266), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 87/282 (30%), Positives = 129/282 (45%), Gaps = 35/282 (12%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPNIVSL 66 + +G GT+G V G+H+ TG VA+K + R + V REI LK RHP+I+ L Sbjct: 12 DTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKL 71 Query: 67 QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 V+ S ++++ E++S + D I +D + QIL G+ +CH V+H Sbjct: 72 YQVISTPSDIFMVMEYVSGG--ELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVH 129 Query: 127 RDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVD 186 RDLKP+N+L+D K+ADFGL+ + T + Y +PEV+ G VD Sbjct: 130 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT-SCGSPNYAAPEVISGRLYAGPEVD 188 Query: 187 IWSIGTI-FAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWK 245 IWS G I +A L P D + LF+ + D P++ Sbjct: 189 IWSSGVILYALLCGTLPF--DDDHVPTLFK-----------------KICDGIFYTPQY- 228 Query: 246 PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 L+ + + LL ML DP KR S K H +F Sbjct: 229 ----------LNPSVISLLKHMLQVDPMKRASIKDIREHEWF 260 >2A27-A nrPDB Length = 321 Score = 107 bits (266), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 83/302 (27%), Positives = 144/302 (47%), Gaps = 38/302 (12%) Query: 1 MEDYTKI-EKIGEGTYGVVYKGRHKTTGQVVA---MKKIRLESEEEGVPSTAI-REISLL 55 +ED+ I E++G G + +V K R K+TG A +KK + + GV I RE+S+L Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSIL 69 Query: 56 KELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 +++ H N+++L DV + + LI E +S + D + + + S++ QIL G Sbjct: 70 RQVLHHNVITLHDVYENRTDVVLILELVSGG--ELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGT----IKLADFGLARAFGIPIRVYTHEVVTLWYRS 171 + + H++++ H DLKP+N+++ DK IKL DFGLA + + + T + + Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVA 186 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PE+ + D+WSIG I L + F GD++ + L I + E + + Sbjct: 187 PEI-VNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQT 245 Query: 232 ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 L D + K+L+ + KR++ + AL HP+ +D Sbjct: 246 SEL-------------------------AKDFIRKLLVKETRKRLTIQEALRHPWITPVD 280 Query: 292 NQ 293 NQ Sbjct: 281 NQ 282 >2GCD-A nrPDB Length = 309 Score = 106 bits (265), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 63/217 (29%), Positives = 113/217 (52%), Gaps = 11/217 (5%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVP-STAIREISLLKELRHPN 62 ++ + +IG G++G VY R +VVA+KK+ ++ I+E+ L++LRHPN Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLD-SIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 + + +++ +L+ E+ L+ P Q ++ + + + LQG+ + HS Sbjct: 77 TIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVE---IAAVTHGALQGLAYLHS 133 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG--SA 179 ++HRD+K N+L+ + G +KL DFG A P + V T ++ +PEV+L Sbjct: 134 HNMIHRDVKAGNILLSEPGLVKLGDFGSASIMA-PANSF---VGTPYWMAPEVILAMDEG 189 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRI 216 +Y VD+WS+G ELA +KP + + L+ I Sbjct: 190 QYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHI 226 >4KS7-A nrPDB Length = 292 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 74/279 (26%), Positives = 133/279 (47%), Gaps = 32/279 (11%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 KIGEG+ G+V R K +G+ VA+K + L ++ E+ ++++ +H N+V + Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRR--ELLFNEVVIMRDYQHFNVVEMYK 87 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 + L+++ EFL L I ++ + + +LQ + + H++ V+HRD Sbjct: 88 SYLVGEELWVLMEFLQ---GGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRD 144 Query: 129 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIW 188 +K ++L+ G +KL+DFG + V T ++ +PEV+ + Y+T VDIW Sbjct: 145 IKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI-SRSLYATEVDIW 203 Query: 189 SIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGS 248 S+G + E+ +P + DS + + R L+D + PK K Sbjct: 204 SLGIMVIEMVDGEPPYFSDSPVQAMKR------------------LRD--SPPPKLKNSH 243 Query: 249 LASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 S V D L +ML+ DP +R + + L+HP+ Sbjct: 244 KVSPVLR------DFLERMLVRDPQERATAQELLDHPFL 276 >6C9D-A nrPDB Length = 459 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 66/217 (30%), Positives = 106/217 (48%), Gaps = 3/217 (1%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 +Y + IG+G + V RH TG+ VA+K I RE+ ++K L HPN Sbjct: 22 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 81 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 IV L +V+ + LYL+ E+ S + D + M ++ QI+ + +CH + Sbjct: 82 IVKLFEVIETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 139 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 ++HRDLK +NLL+D IK+ADFG + F + ++ + Y +PE+ G Sbjct: 140 YIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKL-DEFCGSPPYAAPELFQGKKYDG 198 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA 219 VD+WS+G I L + F G + + R+ R Sbjct: 199 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG 235 >4CFH-A nrPDB Length = 493 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 86/282 (30%), Positives = 129/282 (45%), Gaps = 35/282 (12%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPNIVSL 66 + +G GT+G V G+H+ TG VA+K + R + V REI LK RHP+I+ L Sbjct: 39 DTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKL 98 Query: 67 QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 V+ S ++++ E++S + D I +D + QIL G+ +CH V+H Sbjct: 99 YQVISTPSDIFMVMEYVSGG--ELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVH 156 Query: 127 RDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVD 186 RDLKP+N+L+D K+ADFGL+ + T + Y +PEV+ G VD Sbjct: 157 RDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT-SCGSPNYAAPEVISGRLYAGPEVD 215 Query: 187 IWSIGTI-FAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWK 245 IWS G I +A L P D + LF+ + D P++ Sbjct: 216 IWSSGVILYALLCGTLPF--DDDHVPTLFK-----------------KICDGIFYTPQY- 255 Query: 246 PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 L+ + + LL ML DP KR + K H +F Sbjct: 256 ----------LNPSVISLLKHMLQVDPMKRATIKDIREHEWF 287 >5F9E-A nrPDB Length = 353 Score = 105 bits (262), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 79/295 (26%), Positives = 139/295 (47%), Gaps = 37/295 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES--EEEGVPSTAIREISLLKEL 58 +ED+ + +G+G++G V+ K T Q A+K ++ + ++ V T + + L Sbjct: 18 IEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAW 77 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 HP + + L+ + E+L+ DL ++ S D S Y +I+ G+ Sbjct: 78 EHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSC---HKFDLSRATFYAAEIILGLQ 134 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 F HS+ +++RDLK N+L+D G IK+ADFG+ + + T Y +PE+LLG Sbjct: 135 FLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLG 194 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 +Y+ VD WS G + E+ + FHG E ++LF R + P Sbjct: 195 Q-KYNHSVDWWSFGVLLYEMLIGQSPFHGQDE-EELFHSIR-MDNP-------------- 237 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMAL-NHPYFNDLD 291 +P+W L++ DLL K+ + +P KR+ + + HP F +++ Sbjct: 238 --FYPRW-----------LEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREIN 279 >5JZN-A nrPDB Length = 280 Score = 103 bits (258), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 83/293 (28%), Positives = 134/293 (45%), Gaps = 36/293 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E Y IG+G + VV + ++T + A+K I+ +S+ G E+S+L+ ++HP Sbjct: 19 ERYKVGRTIGDGNFAVVKECVERSTAREYALKIIK-KSKCRGKEHMIQNEVSILRRVKHP 77 Query: 62 NIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 NIV L + + + LYL+ E + DL D+I LY + I + H Sbjct: 78 NIVLLIEEMDVPTELYLVMELVKGGDL---FDAITSTNKYTERDASGMLYNLASAIKYLH 134 Query: 121 SRRVLHRDLKPQNLLI----DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 S ++HRD+KP+NLL+ D ++KL DFGLA P+ T Y +PE++ Sbjct: 135 SLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCG---TPTYVAPEIIA 191 Query: 177 GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 236 + Y VDIW+ G I L P F G + ++ +G + +P Sbjct: 192 ETG-YGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVD---FPS------ 241 Query: 237 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 P W N+ ++ +L++ ML+ D +R S L HP+ ND Sbjct: 242 -----PYWD---------NVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVND 280 >5D7A-A nrPDB Length = 308 Score = 103 bits (256), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 77/298 (25%), Positives = 132/298 (44%), Gaps = 41/298 (13%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHPNIVS 65 +E +G GTYG VYKGRH TGQ+ A+K + + +EE +EI++LK+ H NI + Sbjct: 22 VELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE---EEIKQEINMLKKYSHHRNIAT 78 Query: 66 LQDVLMQ------DSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 ++ D +L+L+ EF L G + + +IL+G+ Sbjct: 79 YYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHL 138 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG-- 177 H +V+HRD+K QN+L+ + +KL DFG++ + + T ++ +PEV+ Sbjct: 139 HQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDE 198 Query: 178 --SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 A Y D+WS+G E+A P + LF I R Sbjct: 199 NPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPR----------------- 241 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 N P+ K + ++ E+ L+ + ++R + + + HP+ D N+ Sbjct: 242 ---NPAPRLKSKKWSKKFQSFIES-------CLVKNHSQRPATEQLMKHPFIRDQPNE 289 >4PDS-A nrPDB Length = 347 Score = 103 bits (256), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 89/304 (29%), Positives = 142/304 (46%), Gaps = 52/304 (17%) Query: 2 EDYTKI-EKIGEGTYGVVYKGRHKTTGQVVAMK---KIRLESEEEGVPSTAIREISLLKE 57 +D++ I E +G+G + V K +TTG+ ++K K ++ +GV RE+ +L++ Sbjct: 30 KDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGV----TRELEVLQK 85 Query: 58 LRHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 L HP IV L+ Y++ EF+S DL +D + + + QIL I Sbjct: 86 LNHPRIVRLKGFYEDTESYYMVMEFVSGGDL---MDFVAAHGAVGEDAGREISRQILTAI 142 Query: 117 VFCHSRRVLHRDLKPQNLLI--DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 + HS + HRDLKP N+LI DD +K+ FGLA+ G + T TL Y +PEV Sbjct: 143 KYIHSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTF-CGTLAYVAPEV 201 Query: 175 LLGS------------ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGT 222 + G YS+ VD+WS+G + + T F G ++ DQL ++ +G Sbjct: 202 IRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQL---YKQIGR 257 Query: 223 PNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMAL 282 + P L+D++ + E D + +L DP R + AL Sbjct: 258 GSYHEGP----LKDFR-----------------ISEEARDFIDSLLQVDPNNRSTAAKAL 296 Query: 283 NHPY 286 NHP+ Sbjct: 297 NHPW 300 >2JAM-A nrPDB Length = 304 Score = 102 bits (254), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 86/288 (29%), Positives = 142/288 (49%), Gaps = 41/288 (14%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 +E +G G + V+ + + TG++ A+K I+ S+ EI++LK+++H NIV+L Sbjct: 14 MEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRD--SSLENEIAVLKKIKHENIVTL 71 Query: 67 QDVLMQDSRLYLIFEFLSMDLKKYLDSI-PPGQYM--DSSLVKSYLYQILQGIVFCHSRR 123 +D+ + YL+ + +S + D I G Y D+SLV + Q+L + + H Sbjct: 72 EDIYESTTHYYLVMQLVSGG--ELFDRILERGVYTEKDASLV---IQQVLSAVKYLHENG 126 Query: 124 VLHRDLKPQNLLI---DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 ++HRDLKP+NLL ++ I + DFGL++ I + T Y +PEV L Sbjct: 127 IVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIM--STACGTPGYVAPEV-LAQKP 183 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 YS VD WSIG I L P F+ ++E +LF + E + E ES Sbjct: 184 YSKAVDCWSIGVITYILLCGYPPFYEETE-SKLFEKIK-------EGYYEFES------- 228 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 P W ++ E+ D + +L DP +R + + AL+HP+ + Sbjct: 229 -PFW---------DDISESAKDFICHLLEKDPNERYTCEKALSHPWID 266 >4FZF-B nrPDB Length = 283 Score = 102 bits (254), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 69/201 (34%), Positives = 114/201 (56%), Gaps = 5/201 (2%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E +TK+E+IG+G++G V+KG T QVVA+K I LE E+ + +EI++L + Sbjct: 8 ELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ-QEITVLSQCDSS 66 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 + ++ S+L++I E+L LD + G + D + + L +IL+G+ + HS Sbjct: 67 YVTKYYGSYLKGSKLWIIMEYLGGG--SALDLLRAGPF-DEFQIATMLKEILKGLDYLHS 123 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 + +HRD+K N+L+ ++G +KLA FG+A V T ++ +PEV+ SA Y Sbjct: 124 EKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSA-Y 182 Query: 182 STPVDIWSIGTIFAELATKKP 202 + DIWS+G ELA +P Sbjct: 183 DSKADIWSLGITAIELAKGEP 203 >2WTK-C nrPDB Length = 305 Score = 102 bits (253), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 78/286 (27%), Positives = 134/286 (46%), Gaps = 39/286 (13%) Query: 10 IGEGTYGVVYKGRHKTT--GQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 +GEG+YG V + T + V + K + + +EI LL+ LRH N++ L Sbjct: 13 LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLV 72 Query: 68 DVLMQD--SRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 125 DVL + ++Y++ E+ +++ LDS+P ++ Y Q++ G+ + HS+ ++ Sbjct: 73 DVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRF-PVCQAHGYFCQLIDGLEYLHSQGIV 131 Query: 126 HRDLKPQNLLIDDKGTIKLADFGLARA---FGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 H+D+KP NLL+ GT+K++ G+A A F T + + ++ PE+ G +S Sbjct: 132 HKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQ-GSPAFQPPEIANGLDTFS 190 Query: 183 T-PVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 241 VDIWS G + T F GD+ ++++F +G + + Sbjct: 191 GFKVDIWSAGVTLYNITTGLYPFEGDN----IYKLFENIGKGSYAI-------------- 232 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 PG + DLL ML Y+PAKR S + H +F Sbjct: 233 ----PGDCGPPLS-------DLLKGMLEYEPAKRFSIRQIRQHSWF 267 >2UV2-A nrPDB Length = 325 Score = 102 bits (253), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 74/262 (28%), Positives = 126/262 (48%), Gaps = 25/262 (9%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 I ++G+G +G VYK ++K T + A K I +SEEE + EI +L HPNIV L Sbjct: 42 IGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEE--LEDYMVEIDILASCDHPNIVKL 99 Query: 67 QDVLMQDSRLYLIFEFLSMDLKKYLDSI--PPGQYMDSSLVKSYLYQILQGIVFCHSRRV 124 D ++ L+++ EF + +D++ + + S ++ Q L + + H ++ Sbjct: 100 LDAFYYENNLWILIEFCA---GGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKI 156 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTP 184 +HRDLK N+L G IKLADFG++ I+ + T ++ +PEV++ P Sbjct: 157 IHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRP 216 Query: 185 ----VDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA----LGTPNNEVWPEVESLQD 236 D+WS+G E+A +P H + + L +I ++ L P+ W + +D Sbjct: 217 YDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSR--WS--SNFKD 272 Query: 237 Y------KNTFPKWKPGSLASH 252 + KN +W L H Sbjct: 273 FLKKCLEKNVDARWTTSQLLQH 294 >5EZV-A nrPDB Length = 560 Score = 101 bits (252), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 71/218 (32%), Positives = 106/218 (48%), Gaps = 7/218 (3%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPN 62 Y + +G GT+G V G H+ TG VA+K + R + V REI LK RHP+ Sbjct: 30 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 89 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 I+ L V+ + +++ E++S + D I ++ + QIL + +CH Sbjct: 90 IIKLYQVISTPTDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 147 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 V+HRDLKP+N+L+D K+ADFGL+ + T + Y +PEV+ G Sbjct: 148 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT-SCGSPNYAAPEVISGRLYAG 206 Query: 183 TPVDIWSIGTI-FAELATKKPLFHGDSEIDQLFRIFRA 219 VDIWS G I +A L P D + LF+ R Sbjct: 207 PEVDIWSCGVILYALLCGTLPF--DDEHVPTLFKKIRG 242 >2F57-A nrPDB Length = 317 Score = 101 bits (252), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 72/279 (25%), Positives = 130/279 (46%), Gaps = 32/279 (11%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 KIGEG+ G+V K TG+ VA+KK+ L ++ E+ ++++ H N+V + Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRR--ELLFNEVVIMRDYHHDNVVDMYS 109 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 + L+++ EFL L I M+ + + +L+ + + H++ V+HRD Sbjct: 110 SYLVGDELWVVMEFLE---GGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRD 166 Query: 129 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIW 188 +K ++L+ G IKL+DFG + V T ++ +PEV + Y T VDIW Sbjct: 167 IKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEV-ISRLPYGTEVDIW 225 Query: 189 SIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGS 248 S+G + E+ +P + + + + RI + + P V+ L Sbjct: 226 SLGIMVIEMIDGEPPYFNEPPLQAMRRI-------RDSLPPRVKDLHK------------ 266 Query: 249 LASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 V ++ LDL ML+ +P++R + + L HP+ Sbjct: 267 ----VSSVLRGFLDL---MLVREPSQRATAQELLGHPFL 298 >4NIF-A nrPDB Length = 333 Score = 101 bits (252), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 89/297 (29%), Positives = 132/297 (44%), Gaps = 40/297 (13%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + Y E IG G+Y + HK T A+K I + PS I EI LL+ +HP Sbjct: 8 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRD---PSEEI-EI-LLRYGQHP 62 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NI++L+DV +YL+ E M + LD I ++ L+ I + + + HS Sbjct: 63 NIITLKDVYDDGKHVYLVTEL--MRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHS 120 Query: 122 RRVLHRDLKPQNLL-IDDKG---TIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 + V+HRDLKP N+L +D+ G +++ DFG A+ + T + +PEVL Sbjct: 121 QGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKR 180 Query: 178 SARYSTPVDIWSIGTI-FAELATKKPLFHGDSEIDQ--LFRIFRALGTPNNEVWPEVESL 234 Y DIWS+G + + LA P +G S+ + L RI T + W V Sbjct: 181 QG-YDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTV--- 236 Query: 235 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 E DL+SKML DP +R++ K L HP+ D Sbjct: 237 ----------------------SETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKD 271 >4CFF-A nrPDB Length = 571 Score = 101 bits (252), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 71/218 (32%), Positives = 106/218 (48%), Gaps = 7/218 (3%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPN 62 Y + +G GT+G V G H+ TG VA+K + R + V REI LK RHP+ Sbjct: 35 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 94 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 I+ L V+ + +++ E++S + D I ++ + QIL + +CH Sbjct: 95 IIKLYQVISTPTDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 152 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 V+HRDLKP+N+L+D K+ADFGL+ + T + Y +PEV+ G Sbjct: 153 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRT-SCGSPNYAAPEVISGRLYAG 211 Query: 183 TPVDIWSIGTI-FAELATKKPLFHGDSEIDQLFRIFRA 219 VDIWS G I +A L P D + LF+ R Sbjct: 212 PEVDIWSCGVILYALLCGTLPF--DDEHVPTLFKKIRG 247 >5DYK-A nrPDB Length = 853 Score = 101 bits (252), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 87/288 (30%), Positives = 131/288 (45%), Gaps = 38/288 (13%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR-EISLLKELRHPNIVSLQD 68 IG GT+G V HK T A+K + S I+ E + E HP I+ L Sbjct: 547 IGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPFIIRLVR 606 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 Y + E ++ + D+I + S + YL I+ I + H R +++RD Sbjct: 607 TFKDSKYFYFLTELVTGG--ELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHERNIVYRD 664 Query: 129 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIW 188 LKP+N+L+D +G +KL DFG A+ + R YT V T Y +PEV+LG Y VDIW Sbjct: 665 LKPENILLDKQGYVKLIDFGCAKK--VQGRAYTL-VGTPHYMAPEVILGKG-YGCTVDIW 720 Query: 189 SIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGS 248 ++G E PL G+ E DQL IFR + T + TFP + Sbjct: 721 ALGICLYEFIC-GPLPFGNDEEDQL-EIFRDILTG--------------QLTFPDYVT-- 762 Query: 249 LASHVKNLDENGLDLLSKMLIYDPAKRISG-----KMALNHPYFNDLD 291 D + ++L+ ++L P RI K +HP+F++ + Sbjct: 763 --------DTDSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNFN 802 >4AF3-A nrPDB Length = 292 Score = 101 bits (251), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 85/288 (29%), Positives = 137/288 (47%), Gaps = 37/288 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELR 59 ++D+ +G+G +G VY R K + +VA+K + + + E+EGV REI + L Sbjct: 22 IDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH 81 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 HPNI+ L + R+YLI E+ +L K L D + + ++ +++ Sbjct: 82 HPNILRLYNYFYDRRRIYLILEYAPRGELYKELQK---SCTFDEQRTATIMEELADALMY 138 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 CH ++V+HRD+KP+NLL+ KG +K+ADFG + +R T TL Y PE++ G Sbjct: 139 CHGKKVIHRDIKPENLLLGLKGELKIADFGWS-VHAPSLRRKTM-CGTLDYLPPEMIEGR 196 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 ++ VD+W IG + EL P F S + RI + D K Sbjct: 197 M-HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV----------------DLK 239 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 FP P DL+SK+L ++P++R+ HP+ Sbjct: 240 --FPASVPTG-----------AQDLISKLLRHNPSERLPLAQVSAHPW 274 >2YZA-A nrPDB Length = 276 Score = 100 bits (250), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 88/288 (30%), Positives = 129/288 (44%), Gaps = 39/288 (13%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPN 62 Y + +G GT+G V G H+ TG VA+K + R + V REI LK RHP+ Sbjct: 13 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 72 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 I+ L V+ + +++ E++S + D I ++ + QIL + +CH Sbjct: 73 IIKLYQVISTPTDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 130 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVLLGSAR 180 V+HRDLKP+N+L+D K+ADFGL+ G +R + Y +PEV+ G Sbjct: 131 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR---DSCGSPNYAAPEVISGRLY 187 Query: 181 YSTPVDIWSIGTI-FAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 VDIWS G I +A L P D + LF+ R V + +Y N Sbjct: 188 AGPEVDIWSCGVILYALLCGTLPF--DDEHVPTLFKKIRG----------GVFYIPEYLN 235 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 S+A+ LL ML DP KR + K H +F Sbjct: 236 R-------SVAT-----------LLMHMLQVDPLKRATIKDIREHEWF 265 >4XBR-A nrPDB Length = 366 Score = 100 bits (250), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 68/282 (24%), Positives = 132/282 (46%), Gaps = 38/282 (13%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 KIGEG+ G+V +++G++VA+KK+ L ++ E+ ++++ +H N+V + + Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR--ELLFNEVVIMRDYQHENVVEMYN 158 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 + L+++ EFL L I M+ + + +LQ + H++ V+HRD Sbjct: 159 SYLVGDELWVVMEFLE---GGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 215 Query: 129 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIW 188 +K ++L+ G +KL+DFG + V T ++ +PE L+ Y VDIW Sbjct: 216 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEVDIW 274 Query: 189 SIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGS 248 S+G + E+ +P + + P +++++ ++ P Sbjct: 275 SLGIMVIEMVDGEPPYFNE---------------------PPLKAMKMIRDNLP------ 307 Query: 249 LASHVKNLDENGLDL---LSKMLIYDPAKRISGKMALNHPYF 287 +KNL + L L ++L+ DPA+R + L HP+ Sbjct: 308 --PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 347 >4RLP-A nrPDB Length = 288 Score = 100 bits (249), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 68/224 (30%), Positives = 120/224 (53%), Gaps = 10/224 (4%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKT---TGQVVAMKKIRLESEEEGVPSTA--IREISLLK 56 E + + +G+G YG V++ R T TG++ AMK ++ TA E ++L+ Sbjct: 5 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 64 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 E++HP IV L +LYLI E+LS + ++ G +M+ + YL +I + Sbjct: 65 EVKHPFIVDLIYAFQTGGKLYLILEYLSGG-ELFMQLEREGIFMEDTAC-FYLAEISMAL 122 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEVL 175 H + +++RDLKP+N++++ +G +KL DFGL + I TH T+ Y +PE+L Sbjct: 123 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKE-SIHDGTVTHTFCGTIEYMAPEIL 181 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA 219 + S ++ VD WS+G + ++ T P F G++ + +I + Sbjct: 182 MRSG-HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC 224 >1PHK-A nrPDB Length = 298 Score = 100 bits (249), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 78/300 (26%), Positives = 130/300 (43%), Gaps = 41/300 (13%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRL-------ESEEEGVPSTAIREISL 54 E+Y E +G G VV + HK T + A+K I + E + + ++E+ + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 55 LKELR-HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQIL 113 L+++ HPNI+ L+D ++ +L+F+ M + D + + + + +L Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDL--MKKGELFDYLTEKVTLSEKETRKIMRALL 134 Query: 114 QGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 173 + I H ++HRDLKP+N+L+DD IKL DFG + P T Y +PE Sbjct: 135 EVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLD-PGEKLREVCGTPSYLAPE 193 Query: 174 VLLGSAR-----YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVW 228 ++ S Y VD+WS G I L P F ++ L I Sbjct: 194 IIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSG--------- 244 Query: 229 PEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 +Y+ P+W + + DL+S+ L+ P KR + + AL HP+F Sbjct: 245 -------NYQFGSPEW---------DDYSDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQ 288 >2Q0N-A nrPDB Length = 301 Score = 100 bits (249), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 68/282 (24%), Positives = 132/282 (46%), Gaps = 38/282 (13%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 KIGEG+ G+V +++G++VA+KK+ L ++ E+ ++++ +H N+V + + Sbjct: 36 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR--ELLFNEVVIMRDYQHENVVEMYN 93 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 + L+++ EFL L I M+ + + +LQ + H++ V+HRD Sbjct: 94 SYLVGDELWVVMEFLE---GGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 150 Query: 129 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIW 188 +K ++L+ G +KL+DFG + V T ++ +PE L+ Y VDIW Sbjct: 151 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEVDIW 209 Query: 189 SIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGS 248 S+G + E+ +P + + P +++++ ++ P Sbjct: 210 SLGIMVIEMVDGEPPYFNE---------------------PPLKAMKMIRDNLP------ 242 Query: 249 LASHVKNLDENGLDL---LSKMLIYDPAKRISGKMALNHPYF 287 +KNL + L L ++L+ DPA+R + L HP+ Sbjct: 243 --PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 282 >3IS5-A nrPDB Length = 285 Score = 100 bits (248), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 81/285 (28%), Positives = 126/285 (44%), Gaps = 37/285 (12%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR-EISLLKELRHPNIVSLQ 67 K+G G +G V+ +++G +K I + + VP I EI +LK L HPNI+ + Sbjct: 29 KLGSGAFGDVHLVEERSSGLERVIKTINKDRSQ--VPMEQIEAEIEVLKSLDHPNIIKIF 86 Query: 68 DVLMQDSRLYLIFEFLSMD--LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 125 +V +Y++ E L++ + + G+ + V + Q++ + + HS+ V+ Sbjct: 87 EVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHSQHVV 146 Query: 126 HRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 H+DLKP+N+L D IK+ DFGLA F T+ T Y +PEV + Sbjct: 147 HKDLKPENILFQDTSPHSPIKIIDFGLAELFKSD-EHSTNAAGTALYMAPEVFKRDVTFK 205 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 DIWS G + L T F G S EV+ YK P Sbjct: 206 --CDIWSAGVVMYFLLTGCLPFTGTS-------------------LEEVQQKATYKE--P 242 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 + A + L +DLL +ML DP +R S L+H +F Sbjct: 243 NY-----AVECRPLTPQAVDLLKQMLTKDPERRPSAAQVLHHEWF 282 >4L42-A nrPDB Length = 346 Score = 100 bits (248), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 68/224 (30%), Positives = 120/224 (53%), Gaps = 10/224 (4%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKT---TGQVVAMKKIRLESEEEGVPSTA--IREISLLK 56 E + + +G+G YG V++ R T TG++ AMK ++ TA E ++L+ Sbjct: 18 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 77 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 E++HP IV L +LYLI E+LS + ++ G +M+ + YL +I + Sbjct: 78 EVKHPFIVDLIYAFQTGGKLYLILEYLSGG-ELFMQLEREGIFMEDTAC-FYLAEISMAL 135 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEVL 175 H + +++RDLKP+N++++ +G +KL DFGL + I TH T+ Y +PE+L Sbjct: 136 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKE-SIHDGTVTHTFCGTIEYMAPEIL 194 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA 219 + S ++ VD WS+G + ++ T P F G++ + +I + Sbjct: 195 MRSG-HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC 237 >4AN9-A nrPDB Length = 301 Score = 100 bits (248), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 85/294 (28%), Positives = 135/294 (45%), Gaps = 36/294 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +D+ KI ++G G GVV+K HK +G V+A K I LE + + + IRE+ +L E P Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP-AIRNQIIRELQVLHECNSP 67 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 IV D + + E MD + + ++ +++G+ + Sbjct: 68 YIVGFYGAFYSDGEISICMEH--MDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 125 Query: 122 R-RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEVLLGSA 179 + +++HRD+KP N+L++ +G IKL DFG++ G I +E V T Y SPE L G+ Sbjct: 126 KHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDEMANEFVGTRSYMSPERLQGT- 181 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 YS DIWS+G E+A + P ++ L DY Sbjct: 182 HYSVQSDIWSMGLSLVEMAVGR------------------YPRPPMAIF----ELLDYIV 219 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 P P L S V +L+ D ++K LI +PA+R K + H + D + Sbjct: 220 NEP---PPKLPSAVFSLEFQ--DFVNKCLIKNPAERADLKQLMVHAFIKRSDAE 268 >3UDB-A nrPDB Length = 317 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 86/290 (29%), Positives = 136/290 (46%), Gaps = 39/290 (13%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPN 62 Y ++ IG G +GV R K ++VA+K I R E +E V REI + LRHPN Sbjct: 21 YELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVK----REIINHRSLRHPN 76 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 IV ++V++ + L ++ E+ S + + I + + Q++ G+ + H+ Sbjct: 77 IVRFKEVILTPTHLAIVMEYASGG--ELFERICNAGRFSEDEARFFFQQLISGVSYAHAM 134 Query: 123 RVLHRDLKPQNLLIDDKGT--IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 +V HRDLK +N L+D +K+ADFG ++A + + + V T Y +PEVLL Sbjct: 135 QVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKS-AVGTPAYIAPEVLLKKEY 193 Query: 181 YSTPVDIWSIG-TIFAELATKKPLFHGDSEIDQLFR--IFRALGTPNNEVWPEVESLQDY 237 D+WS G T++ L P D E + FR I R L ++ DY Sbjct: 194 DGKVADVWSCGVTLYVMLVGAYPF--EDPEEPKNFRKTIHRILNVQY--------AIPDY 243 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 + P+ + L+S++ + DPAKRIS NH +F Sbjct: 244 VHISPECR----------------HLISRIFVADPAKRISIPEIRNHEWF 277 >2X4F-A nrPDB Length = 373 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 89/298 (29%), Positives = 136/298 (45%), Gaps = 54/298 (18%) Query: 5 TKIEKIGEGTYGVVYKGRHKTTGQVVAMK--KIRLESEEEGVPSTAIREISLLKELRHPN 62 +K E +G G +G V+K TG +A K K R ++E V + EIS++ +L H N Sbjct: 92 SKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKN----EISVMNQLDHAN 147 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQY----MDSSLVKSYLYQILQGIVF 118 ++ L D + + L+ E++ D + D I Y +D+ L ++ QI +GI Sbjct: 148 LIQLYDAFESKNDIVLVMEYV--DGGELFDRIIDESYNLTELDTIL---FMKQICEGIRH 202 Query: 119 CHSRRVLHRDLKPQNLLI--DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL- 175 H +LH DLKP+N+L D IK+ DFGLAR R E + + + +PE L Sbjct: 203 MHQMYILHLDLKPENILCVNRDAKQIKIIDFGLAR------RYKPREKLKVNFGTPEFLA 256 Query: 176 ---LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP-EV 231 + S P D+WS+G I L + F GD++ + L I W E Sbjct: 257 PEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACR-------WDLED 309 Query: 232 ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 E QD + E + +SK+LI + + RIS AL HP+ +D Sbjct: 310 EEFQD-------------------ISEEAKEFISKLLIKEKSWRISASEALKHPWLSD 348 >3ZUT-A nrPDB Length = 362 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 84/290 (28%), Positives = 136/290 (46%), Gaps = 39/290 (13%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPN 62 Y ++ IG G +GV R K + ++VA+K I R E +E V REI + LRHPN Sbjct: 21 YELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVK----REIINHRSLRHPN 76 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 IV ++V++ + L ++ E+ S + + I + + Q++ G+ +CH+ Sbjct: 77 IVRFKEVILTPTHLAIVMEYASG--GELFERICNAGRFSEDEARFFFQQLISGVSYCHAM 134 Query: 123 RVLHRDLKPQNLLIDDKGT--IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 +V HRDLK +N L+D +K+ FG +++ + + + V T Y +PEVLL Sbjct: 135 QVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKS-TVGTPAYIAPEVLLKKEY 193 Query: 181 YSTPVDIWSIG-TIFAELATKKPLFHGDSEIDQLFR--IFRALGTPNNEVWPEVESLQDY 237 D+WS G T++ L P D E + FR I R L ++ DY Sbjct: 194 DGKVADVWSCGVTLYVMLVGAYPF--EDPEEPKNFRKTIHRILNVQY--------AIPDY 243 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 + P+ + L+S++ + DPAKRIS NH +F Sbjct: 244 VHISPECR----------------HLISRIFVADPAKRISIPEIRNHEWF 277 >4JDH-A nrPDB Length = 346 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 68/282 (24%), Positives = 132/282 (46%), Gaps = 38/282 (13%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 KIGEG+ G+V +++G++VA+KK+ L ++ E+ ++++ +H N+V + + Sbjct: 81 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR--ELLFNEVVIMRDYQHENVVEMYN 138 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 + L+++ EFL L I M+ + + +LQ + H++ V+HRD Sbjct: 139 SYLVGDELWVVMEFLE---GGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 195 Query: 129 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIW 188 +K ++L+ G +KL+DFG + V T ++ +PE L+ Y VDIW Sbjct: 196 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEVDIW 254 Query: 189 SIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGS 248 S+G + E+ +P + + P +++++ ++ P Sbjct: 255 SLGIMVIEMVDGEPPYFNE---------------------PPLKAMKMIRDNLP------ 287 Query: 249 LASHVKNLDENGLDL---LSKMLIYDPAKRISGKMALNHPYF 287 +KNL + L L ++L+ DPA+R + L HP+ Sbjct: 288 --PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 327 >3UTO-A nrPDB Length = 573 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 80/292 (27%), Positives = 133/292 (45%), Gaps = 38/292 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++ Y E++G G +GVV++ + TG A K + E + T +EI + LRH Sbjct: 156 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDK--ETVRKEIQTMSVLRH 213 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMD--LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 P +V+L D D+ + +I+EF+S +K D M Y+ Q+ +G+ Sbjct: 214 PTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADE---HNKMSEDEAVEYMRQVCKGLCH 270 Query: 119 CHSRRVLHRDLKPQNLLIDDKGT--IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 H +H DLKP+N++ K + +KL DFGL A P + T + +PEV Sbjct: 271 MHENNYVHLDLKPENIMFTTKRSNELKLIDFGLT-AHLDPKQSVKVTTGTAEFAAPEVAE 329 Query: 177 GS-ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 G Y T D+WS+G + L + F G+++ D+ R ++ W ++ Sbjct: 330 GKPVGYYT--DMWSVGVLSYILLSGLSPFGGEND-DETLRNVKSCD------W----NMD 376 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 D S + E+G D + K+L+ DP R++ AL HP+ Sbjct: 377 D--------------SAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWL 414 >4FIE-A nrPDB Length = 423 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 68/282 (24%), Positives = 132/282 (46%), Gaps = 38/282 (13%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 KIGEG+ G+V +++G++VA+KK+ L ++ E+ ++++ +H N+V + + Sbjct: 158 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR--ELLFNEVVIMRDYQHENVVEMYN 215 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 + L+++ EFL L I M+ + + +LQ + H++ V+HRD Sbjct: 216 SYLVGDELWVVMEFLE---GGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 272 Query: 129 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIW 188 +K ++L+ G +KL+DFG + V T ++ +PE L+ Y VDIW Sbjct: 273 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLPYGPEVDIW 331 Query: 189 SIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGS 248 S+G + E+ +P + + P +++++ ++ P Sbjct: 332 SLGIMVIEMVDGEPPYFNE---------------------PPLKAMKMIRDNLP------ 364 Query: 249 LASHVKNLDENGLDL---LSKMLIYDPAKRISGKMALNHPYF 287 +KNL + L L ++L+ DPA+R + L HP+ Sbjct: 365 --PRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 404 >1KOA-A nrPDB Length = 491 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 80/292 (27%), Positives = 133/292 (45%), Gaps = 38/292 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++ Y E++G G +GVV++ + TG A K + E + T +EI + LRH Sbjct: 50 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDK--ETVRKEIQTMSVLRH 107 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMD--LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 P +V+L D D+ + +I+EF+S +K D M Y+ Q+ +G+ Sbjct: 108 PTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADE---HNKMSEDEAVEYMRQVCKGLCH 164 Query: 119 CHSRRVLHRDLKPQNLLIDDKGT--IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 H +H DLKP+N++ K + +KL DFGL A P + T + +PEV Sbjct: 165 MHENNYVHLDLKPENIMFTTKRSNELKLIDFGLT-AHLDPKQSVKVTTGTAEFAAPEVAE 223 Query: 177 GS-ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 G Y T D+WS+G + L + F G+++ D+ R ++ W ++ Sbjct: 224 GKPVGYYT--DMWSVGVLSYILLSGLSPFGGEND-DETLRNVKSCD------W----NMD 270 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 D S + E+G D + K+L+ DP R++ AL HP+ Sbjct: 271 D--------------SAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWL 308 >4JG6-A nrPDB Length = 355 Score = 99.0 bits (245), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 84/298 (28%), Positives = 134/298 (44%), Gaps = 40/298 (13%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + Y E IG G+Y V + HK T A+K I + P+ I EI LL+ +HP Sbjct: 35 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRD---PTEEI-EI-LLRYGQHP 89 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NI++L+DV +Y++ E M + LD I ++ + L+ I + + + H+ Sbjct: 90 NIITLKDVYDDGKYVYVVTEL--MKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHA 147 Query: 122 RRVLHRDLKPQNLL-IDDKG---TIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 + V+HRDLKP N+L +D+ G +I++ DFG A+ + T + +PEVL Sbjct: 148 QGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLER 207 Query: 178 SARYSTPVDIWSIGTIFAELATK-KPLFHG--DSEIDQLFRIFRALGTPNNEVWPEVESL 234 Y DIWS+G + + T P +G D+ + L RI + + W V Sbjct: 208 QG-YDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVS-- 264 Query: 235 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 + DL+SKML DP +R++ + L HP+ D Sbjct: 265 -----------------------DTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQ 299 >3DAK-A nrPDB Length = 290 Score = 98.2 bits (243), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 83/301 (27%), Positives = 138/301 (45%), Gaps = 37/301 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +DY E IG G VV + VA+K+I LE + + ++EI + + HP Sbjct: 10 DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDEL-LKEIQAMSQCHHP 68 Query: 62 NIVSLQDVLMQDSRLYLIFEFLS----MDLKKYLDSIPPGQY----MDSSLVKSYLYQIL 113 NIVS + L+L+ + LS +D+ K++ + G++ +D S + + L ++L Sbjct: 69 NIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHI--VAKGEHKSGVLDESTIATILREVL 126 Query: 114 QGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLAR--AFGIPI---RVYTHEVVTLW 168 +G+ + H +HRD+K N+L+ + G++++ADFG++ A G I +V V T Sbjct: 127 EGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPC 186 Query: 169 YRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVW 228 + +PEV+ Y DIWS G ELAT +H + L + P+ E Sbjct: 187 WMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQN-DPPSLETG 245 Query: 229 -PEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 + E L+ Y +F K ++S L DP KR + L H +F Sbjct: 246 VQDKEMLKKYGKSFRK-------------------MISLCLQKDPEKRPTAAELLRHKFF 286 Query: 288 N 288 Sbjct: 287 Q 287 >5KKR-C nrPDB Length = 395 Score = 97.8 bits (242), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 90/314 (28%), Positives = 146/314 (46%), Gaps = 34/314 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +D+ KI ++G G GVV+K HK +G V+A K I LE + + + IRE+ +L E P Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP-AIRNQIIRELQVLHECNSP 126 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 IV D + + E MD + + ++ +++G+ + Sbjct: 127 YIVGFYGAFYSDGEISICMEH--MDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 184 Query: 122 R-RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEVLLGSA 179 + +++HRD+KP N+L++ +G IKL DFG++ G I + V T Y SPE L G+ Sbjct: 185 KHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMSPERLQGT- 240 Query: 180 RYSTPVDIWSIGTIFAELATKK-PLFHGDS-EIDQLFRI----------------FRALG 221 YS DIWS+G E+A + P+ D+ E++ +F R L Sbjct: 241 HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLS 300 Query: 222 TPNNEVWPEVE--SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGK 279 + + P + L DY P P L S V +L+ D ++K LI +PA+R K Sbjct: 301 SYGMDSRPPMAIFELLDYIVNEP---PPKLPSAVFSLEFQ--DFVNKCLIKNPAERADLK 355 Query: 280 MALNHPYFNDLDNQ 293 + H + D + Sbjct: 356 QLMVHAFIKRSDAE 369 >6CMJ-A nrPDB Length = 321 Score = 97.4 bits (241), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 119/218 (54%), Gaps = 17/218 (7%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMK---KIRLESEEEGV--PSTAI----RE 51 ++ YT ++IG+G+YGVV ++ AMK K +L + G P I +E Sbjct: 33 LDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQE 92 Query: 52 ISLLKELRHPNIVSLQDVL--MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYL 109 I++LK+L HPN+V L +VL + LY++FE ++ + ++ P + + Y Sbjct: 93 IAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKP---LSEDQARFYF 149 Query: 110 YQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWY 169 +++GI + H ++++HRD+KP NLL+ + G IK+ADFG++ F + ++ V T + Sbjct: 150 QDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAF 209 Query: 170 RSPEVLLGSARY--STPVDIWSIG-TIFAELATKKPLF 204 +PE L + + +D+W++G T++ + + P Sbjct: 210 MAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFM 247 >3EQC-A nrPDB Length = 360 Score = 97.1 bits (240), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 64/202 (31%), Positives = 103/202 (50%), Gaps = 9/202 (4%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +D+ KI ++G G GVV+K HK +G V+A K I LE + + + IRE+ +L E P Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKP-AIRNQIIRELQVLHECNSP 91 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 IV D + + E MD + + ++ +++G+ + Sbjct: 92 YIVGFYGAFYSDGEISICMEH--MDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE 149 Query: 122 R-RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEVLLGSA 179 + +++HRD+KP N+L++ +G IKL DFG++ G I + V T Y SPE L G+ Sbjct: 150 KHKIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMSPERLQGT- 205 Query: 180 RYSTPVDIWSIGTIFAELATKK 201 YS DIWS+G E+A + Sbjct: 206 HYSVQSDIWSMGLSLVEMAVGR 227 >5FET-A nrPDB Length = 847 Score = 97.1 bits (240), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 82/260 (31%), Positives = 122/260 (46%), Gaps = 17/260 (6%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR-EISLLKELRHPNIVSLQD 68 IG GT+G V HK T A+K + S I+ E + E HP I+ L Sbjct: 541 IGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAENDHPFIIRLVR 600 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 + Y + E ++ + D+I + + YL I+ I + H R +++RD Sbjct: 601 TFKDSNCFYFLTELVTGG--ELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERNIVYRD 658 Query: 129 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIW 188 LKP+N+L+D +G +KL DFG A+ I R YT V T Y +PEV+LG Y VDIW Sbjct: 659 LKPENILLDKQGYVKLIDFGCAKK--IQGRAYTL-VGTPHYMAPEVILGKG-YGCTVDIW 714 Query: 189 SIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN-------TF 241 ++G E PL G+ + DQL IFR + T +P+ S QD N Sbjct: 715 ALGVCLYEFIC-GPLPFGNDQEDQL-EIFRDILT-GQLTFPDYVSDQDSINLMKRLLCRL 771 Query: 242 PKWKPGSLASHVKNLDENGL 261 P+ + G + K++ E+ Sbjct: 772 PQGRIGCSINGFKDIKEHAF 791 >5X8I-B nrPDB Length = 346 Score = 96.7 bits (239), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 101/341 (29%), Positives = 148/341 (43%), Gaps = 67/341 (19%) Query: 4 YTKIEKIGEGTYG-VVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR--H 60 Y ++ +GEG +G VV HK G+ VA+K ++ + A EI +L+ L Sbjct: 15 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK---NVDRYCEAARSEIQVLEHLNTTD 71 Query: 61 PN----IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSL--VKSYLYQILQ 114 PN V + + + ++FE L + D I ++ L ++ YQI + Sbjct: 72 PNSTFRCVQMLEWFEHHGHICIVFELLGLST---YDFIKENGFLPFRLDHIRKMAYQICK 128 Query: 115 GIVFCHSRRVLHRDLKPQNLLI--------------DDKGT-----IKLADFGLARAFGI 155 + F HS ++ H DLKP+N+L D+ T IK+ DFG A Sbjct: 129 SVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA----- 183 Query: 156 PIRVYTHE-----VVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEI 210 Y E V T YR+PEV+L +S P D+WSIG I E +F Sbjct: 184 ---TYDDEHHSTLVSTRHYRAPEVILALG-WSQPCDVWSIGCILIEYYLGFTVFPTHDSK 239 Query: 211 DQLFRIFRALG-TPNNEV---------------WPEVESLQDYKNTFPK-WKPGSLASHV 253 + L + R LG P + + W E S Y + K K L+ V Sbjct: 240 EHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDV 299 Query: 254 KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294 ++ E DL+ KML YDPAKRI+ + AL HP+F+ L I Sbjct: 300 EH--ERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 338 >4UYA-A nrPDB Length = 340 Score = 95.5 bits (236), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 69/212 (32%), Positives = 108/212 (50%), Gaps = 21/212 (9%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPS--TAIREISLLKELRHPNIVS 65 E IG G +G VY R GQ VA+K R + E++ + + RE L LRHPNI+ Sbjct: 32 ELIGAGGFGQVY--RATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIE 89 Query: 66 LQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR-- 123 L+ V +Q L L+ EF L+ G+ + ++ ++ QI +G+++ H Sbjct: 90 LRGVCLQQPHLCLVLEFAR---GGALNRALAGRRIPPHVLVNWAVQIARGMLYLHEEAFV 146 Query: 124 -VLHRDLKPQNLLIDDK--------GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 +LHRDLK N+L+ +K T+K+ DFGLAR + ++ T + +PEV Sbjct: 147 PILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAYA--WMAPEV 204 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHG 206 + S+ +S DIWS G + EL T + + G Sbjct: 205 -IKSSLFSKGSDIWSYGVLLWELLTGEVPYRG 235 >1KOB-A nrPDB Length = 387 Score = 95.5 bits (236), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 74/287 (25%), Positives = 130/287 (45%), Gaps = 34/287 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y +E++G G +GVV++ K TG+V K I + T EIS++ +L HP + Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKY--TVKNEISIMNQLHHPKL 110 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQY-MDSSLVKSYLYQILQGIVFCHSR 122 ++L D + LI EFLS + D I Y M + V +Y+ Q +G+ H Sbjct: 111 INLHDAFEDKYEMVLILEFLSGG--ELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEH 168 Query: 123 RVLHRDLKPQNLLIDDK--GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 ++H D+KP+N++ + K ++K+ DFGLA P + T + +PE+ + Sbjct: 169 SIVHLDIKPENIMCETKKASSVKIIDFGLATKLN-PDEIVKVTTATAEFAAPEI-VDREP 226 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 D+W+IG + L + F G+ ++ E+LQ+ K Sbjct: 227 VGFYTDMWAIGVLGYVLLSGLSPFAGEDDL---------------------ETLQNVKRC 265 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 ++ + +S + D + +L +P KR++ AL HP+ Sbjct: 266 DWEFDEDAFSS----VSPEAKDFIKNLLQKEPRKRLTVHDALEHPWL 308 >3PPZ-A nrPDB Length = 309 Score = 95.1 bits (235), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 65/195 (33%), Positives = 101/195 (51%), Gaps = 6/195 (3%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 EKIG G++G V+ R + G VA+K + + + +RE++++K LRHPNIV Sbjct: 43 EKIGAGSFGTVH--RAEWHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLFM 100 Query: 68 DVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR--V 124 + Q L ++ E+LS L + L + +D S Y + +G+ + H+R + Sbjct: 101 GAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPI 160 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTP 184 +HRDLK NLL+D K T+K+ DFGL+R T + +PEVL + Sbjct: 161 VHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPS-NEK 219 Query: 185 VDIWSIGTIFAELAT 199 D++S G I ELAT Sbjct: 220 SDVYSFGVILWELAT 234 >3TXO-A nrPDB Length = 353 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 80/302 (26%), Positives = 140/302 (46%), Gaps = 46/302 (15%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIR----LESEEEGVPSTAIREISLLK 56 ++++ I +G+G++G V R K TG + A+K ++ L+ ++ T R +SL + Sbjct: 22 IDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLAR 81 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 HP + L RL+ + EF++ + I + D + + Y +I+ + Sbjct: 82 --NHPFLTQLFCCFQTPDRLFFVMEFVNG--GDLMFHIQKSRRFDEARARFYAAEIISAL 137 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEVL 175 +F H + +++RDLK N+L+D +G KLADFG+ + GI V T T Y +PE+ Sbjct: 138 MFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKE-GICNGVTTATFCGTPDYIAPEI- 195 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 L Y VD W++G + E+ F ++E D +F A+ N+EV Sbjct: 196 LQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDD----LFEAI--LNDEV-------- 241 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMA-LNHPYFND 289 +P W L E+ +L + +P R+ G+ A L HP+F + Sbjct: 242 ----VYPTW-----------LHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKE 286 Query: 290 LD 291 +D Sbjct: 287 ID 288 >1S9I-A nrPDB Length = 354 Score = 94.4 bits (233), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 62/202 (30%), Positives = 104/202 (51%), Gaps = 9/202 (4%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +D+ +I ++G G GVV K +H+ +G ++A K I LE + + + IRE+ +L E P Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKP-AIRNQIIRELQVLHECNSP 74 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 IV D + + E MD + + + ++ +L+G+ + Sbjct: 75 YIVGFYGAFYSDGEISICMEH--MDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLRE 132 Query: 122 R-RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEVLLGSA 179 + +++HRD+KP N+L++ +G IKL DFG++ G I + V T Y +PE L G+ Sbjct: 133 KHQIMHRDVKPSNILVNSRGEIKLCDFGVS---GQLIDSMANSFVGTRSYMAPERLQGT- 188 Query: 180 RYSTPVDIWSIGTIFAELATKK 201 YS DIWS+G ELA + Sbjct: 189 HYSVQSDIWSMGLSLVELAVGR 210 >4CSV-A nrPDB Length = 275 Score = 94.4 bits (233), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 67/228 (29%), Positives = 115/228 (50%), Gaps = 22/228 (9%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTA--IREISLLKELRHPNIVSL 66 K+G G +G VY+G+ + VA+K ++ EG S ++E ++K+L+HPN+V L Sbjct: 18 KLGSGQFGEVYEGKWRNYNIEVAVKTLK-----EGTMSVEEFLQEAQIMKKLKHPNLVQL 72 Query: 67 QDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 125 V ++ +Y+I E++S L YL G +++ + Q+ G+ + S+ + Sbjct: 73 YGVCTKEPPIYIITEYMSHGSLLDYLRDCE-GHTVNAQALLDMAAQVASGMAYLESQNFI 131 Query: 126 HRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV---VTLWYRSPEVLLGSARYS 182 HRDL +N L+ + +K+ADFGLAR I YT + + +PE + R+S Sbjct: 132 HRDLAARNCLVGENNVVKVADFGLARL--INEDEYTARAGAKFPIKWTAPEA-ISYNRFS 188 Query: 183 TPVDIWSIGTIFAELATKK----PLFHGDSEIDQL---FRIFRALGTP 223 D+W+ G + E+ T P G I+Q+ +R+ R G P Sbjct: 189 IKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCP 236 >2W1I-A nrPDB Length = 326 Score = 94.4 bits (233), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 67/204 (32%), Positives = 107/204 (52%), Gaps = 17/204 (8%) Query: 7 IEKIGEGTYGVVYKGRHK----TTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 ++++G+G +G V R+ TG+VVA+KK++ +EE REI +LK L+H N Sbjct: 46 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEH--LRDFEREIEILKSLQHDN 103 Query: 63 IVSLQDVLMQDSR--LYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 IV + V R L LI E+L L+ YL + +D + Y QI +G+ + Sbjct: 104 IVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQK--HKERIDHIKLLQYTSQICKGMEYL 161 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT----HEVVTLWYRSPEVL 175 ++R +HRDL +N+L++++ +K+ DFGL + Y E WY +PE L Sbjct: 162 GTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY-APESL 220 Query: 176 LGSARYSTPVDIWSIGTIFAELAT 199 S ++S D+WS G + EL T Sbjct: 221 TES-KFSVASDVWSFGVVLYELFT 243 >3IO7-A nrPDB Length = 313 Score = 94.0 bits (232), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 67/204 (32%), Positives = 107/204 (52%), Gaps = 17/204 (8%) Query: 7 IEKIGEGTYGVVYKGRHK----TTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 ++++G+G +G V R+ TG+VVA+KK++ +EE REI +LK L+H N Sbjct: 33 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEH--LRDFEREIEILKSLQHDN 90 Query: 63 IVSLQDVLMQDSR--LYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 IV + V R L LI E+L L+ YL + +D + Y QI +G+ + Sbjct: 91 IVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQK--HKERIDHIKLLQYTSQICKGMEYL 148 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT----HEVVTLWYRSPEVL 175 ++R +HRDL +N+L++++ +K+ DFGL + Y E WY +PE L Sbjct: 149 GTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY-APESL 207 Query: 176 LGSARYSTPVDIWSIGTIFAELAT 199 S ++S D+WS G + EL T Sbjct: 208 TES-KFSVASDVWSFGVVLYELFT 230 >5DBX-A nrPDB Length = 328 Score = 94.0 bits (232), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 80/300 (26%), Positives = 138/300 (46%), Gaps = 37/300 (12%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 E IG G VV K + VA+K+I LE + + ++EI + + HPN+V+ Sbjct: 17 EVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSM-DELLKEIQAMSQCSHPNVVTYY 75 Query: 68 DVLMQDSRLYLIFEFLS----MDLKKYLDSIPPGQY----MDSSLVKSYLYQILQGIVFC 119 + L+L+ + LS +D+ KY+ + G++ ++ +++ + L ++L+G+ + Sbjct: 76 TSFVVKDELWLVMKLLSGGSMLDIIKYI--VNRGEHKNGVLEEAIIATILKEVLEGLDYL 133 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLAR--AFGIPI---RVYTHEVVTLWYRSPEV 174 H +HRDLK N+L+ + G++++ADFG++ A G + +V V T + +PEV Sbjct: 134 HRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWMAPEV 193 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPE-VES 233 + Y D+WS G ELAT +H + L + P E E E Sbjct: 194 MEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQN-DPPTLETGVEDKEM 252 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 ++ Y +F K LLS L DP+KR + L +F N+ Sbjct: 253 MKKYGKSFRK-------------------LLSLCLQKDPSKRPTAAELLKCKFFQKAKNR 293 >3UC3-A nrPDB Length = 361 Score = 93.6 bits (231), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 78/289 (26%), Positives = 133/289 (46%), Gaps = 37/289 (12%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y ++ IG G +GV R K T ++VA+K I + + REI + LRHPNI Sbjct: 22 YDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGA---AIDENVQREIINHRSLRHPNI 78 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 V ++V++ + L +I E+ S + Y G++ + + + Q+L G+ +CHS + Sbjct: 79 VRFKEVILTPTHLAIIMEYASGG-ELYERICNAGRFSEDE-ARFFFQQLLSGVSYCHSMQ 136 Query: 124 VLHRDLKPQNLLIDDKGT--IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 + HRDLK +N L+D +K+ DFG +++ + + + V T Y +PEVLL Sbjct: 137 ICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKS-TVGTPAYIAPEVLLRQEYD 195 Query: 182 STPVDIWSIG-TIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 D+WS G T++ L P + + E +DY+ T Sbjct: 196 GKIADVWSCGVTLYVMLVGAYP-------------------------FEDPEEPRDYRKT 230 Query: 241 FPKWKPG--SLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 + S+ ++ + L+S++ + DPA RIS H +F Sbjct: 231 IQRILSVKYSIPDDIR-ISPECCHLISRIFVADPATRISIPEIKTHSWF 278 >5LOH-A nrPDB Length = 341 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 82/299 (27%), Positives = 132/299 (44%), Gaps = 40/299 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIR-LESEEEGVPSTAIREISLLKELR 59 +E+++ ++ I G +G VY G+ G++ A+K ++ + + + E L + Sbjct: 35 IEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSK 92 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 P IV L L + +YL+ E+L D+K L Y D + Y+ ++ + + Sbjct: 93 SPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIY---GYFDEEMAVKYISEVALALDY 149 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF------GIPIRVYTHEVVTLWYRSP 172 H ++HRDLKP N+LI ++G IKL DFGL++ + I T Y +P Sbjct: 150 LHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAP 209 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 E+LLG A + VD W++G E T P F+ D Q+F+ P WPE E Sbjct: 210 ELLLGRA-HGPAVDWWALGVCLFEFLTGIPPFN-DETPQQVFQNILKRDIP----WPEGE 263 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 + L +N + +L D KR K HP F+D+D Sbjct: 264 ---------------------EKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVD 301 >5X3F-B nrPDB Length = 393 Score = 93.2 bits (230), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 65/217 (29%), Positives = 117/217 (53%), Gaps = 19/217 (8%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMK------KIRLESEEEGVPSTAIREISL 54 ++ + +I+ +G G++G V +HK +G AMK ++L+ E + E + Sbjct: 83 LDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEH-----TLNEKRI 137 Query: 55 LKELRHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQIL 113 L+ + P +V L+ +S LY++ E+++ ++ +L I G++ + + Y QI+ Sbjct: 138 LQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRI--GRFSEPH-ARFYAAQIV 194 Query: 114 QGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 173 + HS +++RDLKP+NLLID +G I++ DFG A+ + R +T T Y +PE Sbjct: 195 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTL-CGTPEYLAPE 251 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEI 210 ++L S Y+ VD W++G + E+A P F D I Sbjct: 252 IIL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI 287 >3F3Z-A nrPDB Length = 277 Score = 93.2 bits (230), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 76/294 (25%), Positives = 126/294 (42%), Gaps = 49/294 (16%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAI-------REISLLK 56 YT IG G++G V ++ K R+ + +P + +EI ++K Sbjct: 11 YTLENTIGRGSWGEV---------KIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMK 61 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 L HPNI+ L + ++ +YL+ E + + + + + S + +L + Sbjct: 62 SLDHPNIIRLYETFEDNTDIYLVMELCTGG--ELFERVVHKRVFRESDAARIMKDVLSAV 119 Query: 117 VFCHSRRVLHRDLKPQNLLI---DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 173 +CH V HRDLKP+N L +KL DFGLA F P ++ +V T +Y SP+ Sbjct: 120 AYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFK-PGKMMRTKVGTPYYVSPQ 178 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 233 VL G Y D WS G + L P F ++ + + +I T +PE Sbjct: 179 VLEG--LYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFT-----FPE--- 228 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 +D+ N P+ + L+ ++L P +RI+ AL H +F Sbjct: 229 -KDWLNVSPQAE----------------SLIRRLLTKSPKQRITSLQALEHEWF 265 >4WB7-A nrPDB Length = 405 Score = 93.2 bits (230), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 66/217 (30%), Positives = 116/217 (53%), Gaps = 19/217 (8%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMK------KIRLESEEEGVPSTAIREISL 54 ++ + +I+ +G G++G V +HK TG AMK ++L+ E + E + Sbjct: 95 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEH-----TLNEKRI 149 Query: 55 LKELRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQIL 113 L+ + P +V L+ +S LY++ E++ ++ +L I G++ + + Y QI+ Sbjct: 150 LQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRI--GRFSEPH-ARFYAAQIV 206 Query: 114 QGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 173 + HS +++RDLKP+NLLID +G I++ DFG A+ + R +T T Y +PE Sbjct: 207 LTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKR--VKGRTWTL-CGTPEYLAPE 263 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEI 210 ++L S Y+ VD W++G + E+A P F D I Sbjct: 264 IIL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI 299 >4IAN-A nrPDB Length = 358 Score = 93.2 bits (230), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 90/318 (28%), Positives = 138/318 (43%), Gaps = 45/318 (14%) Query: 11 GEGTYGVVYKGR-HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN------I 63 G+G + V + R + Q VA+K IR E + T ++E+ LK+L + Sbjct: 39 GQGVFSNVVRARDNARANQEVAVKIIR---NNELMQKTGLKELEFLKKLNDADPDDKFHC 95 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 + L L L+FE LSM+L++ L + V+SY Q+ + Sbjct: 96 LRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCN 155 Query: 124 VLHRDLKPQNLLIDDKGTI-KLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 +LH D+KP N+L+++ TI KL DFG A + T +V+ +YR+PE+++G + Y Sbjct: 156 ILHADIKPDNILVNESKTILKLCDFG--SASHVADNDITPYLVSRFYRAPEIIIGKS-YD 212 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG-TPNNEVWPEVESLQDYKNTF 241 +D+WS+G EL T K LF G + L G PN + V Q + Sbjct: 213 YGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNL 272 Query: 242 -------------PKWKPGSLASHVKNL--DENGL---------------DLLSKMLIYD 271 K S + K+L D G DLL ++L+ D Sbjct: 273 NFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLD 332 Query: 272 PAKRISGKMALNHPYFND 289 PAKRIS AL H + + Sbjct: 333 PAKRISINQALQHAFIQE 350 >6DBN-A nrPDB Length = 316 Score = 92.8 bits (229), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 80/283 (28%), Positives = 131/283 (46%), Gaps = 29/283 (10%) Query: 6 KIEKIGEGTYGVV----YKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +I +GEG +G V Y TG+ VA+K ++ ES + +EI +L+ L H Sbjct: 39 RIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLK-KEIEILRNLYHE 97 Query: 62 NIVSLQDVLMQD--SRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 NIV + + +D + + LI EFL S LK+YL + L Y QI +G+ + Sbjct: 98 NIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQL--KYAVQICKGMDY 155 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT----HEVVTLWYRSPEV 174 SR+ +HRDL +N+L++ + +K+ DFGL +A YT + WY +PE Sbjct: 156 LGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWY-APEC 214 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 L+ S ++ D+WS G EL T + DS+ + + +G + ++ ++ Sbjct: 215 LMQS-KFYIASDVWSFGVTLHELLT-----YCDSDSSPMALFLKMIGPTHGQM-----TV 263 Query: 235 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS 277 NT K G N + L+ K + P+ R S Sbjct: 264 TRLVNTL---KEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTS 303 >3QA8-A nrPDB Length = 676 Score = 92.8 bits (229), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 64/202 (31%), Positives = 104/202 (51%), Gaps = 13/202 (6%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 E++G G +G V + H+ TG+ VA+K+ R E + + EI ++K+L HPN+VS + Sbjct: 20 ERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCL-EIQIMKKLNHPNVVSAR 78 Query: 68 DV------LMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 +V L + L E+ DL+KYL+ + +++ L I + + H Sbjct: 79 EVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALRYLH 138 Query: 121 SRRVLHRDLKPQNLLID---DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 R++HRDLKP+N+++ + K+ D G A+ + T V TL Y +PE LL Sbjct: 139 ENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQG-ELCTEFVGTLQYLAPE-LLE 196 Query: 178 SARYSTPVDIWSIGTIFAELAT 199 +Y+ VD WS GT+ E T Sbjct: 197 QKKYTVTVDYWSFGTLAFECIT 218 >2A1A-B nrPDB Length = 284 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 63/212 (29%), Positives = 107/212 (50%), Gaps = 26/212 (12%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D+ +IE IG G +G V+K +H+ G+ +K+++ +E+ A RE+ L +L H N Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEK------AEREVKALAKLDHVN 65 Query: 63 IV----------------SLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLV 105 IV S + L++ EF L+++++ G+ +D L Sbjct: 66 IVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK-RRGEKLDKVLA 124 Query: 106 KSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV 165 QI +G+ + HS+++++RDLKP N+ + D +K+ DFGL + + T Sbjct: 125 LELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGK-RTRSKG 183 Query: 166 TLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL 197 TL Y SPE + S Y VD++++G I AEL Sbjct: 184 TLRYMSPE-QISSQDYGKEVDLYALGLILAEL 214 >5N23-A nrPDB Length = 352 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 68/221 (30%), Positives = 113/221 (51%), Gaps = 26/221 (11%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMK------KIRLESEEEGVPSTAIREISL 54 ++ + +I +G G++G V +HK TG AMK ++L+ E + E + Sbjct: 41 LDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEH-----TLNEKRI 95 Query: 55 LKELRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQIL 113 + + P +V L+ +S LY++ E+ ++ +L I G++ + + Y QI+ Sbjct: 96 QQAVNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRI--GRFSEPH-ARFYAAQIV 152 Query: 114 QGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLW----Y 169 + HS +++RDLKP+NLLID +G IK+ADFG A+ RV TL Y Sbjct: 153 LTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAK------RVKGRTPWTLCGTPEY 206 Query: 170 RSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEI 210 +PE++L S Y+ VD W++G + E+A P F D I Sbjct: 207 LAPEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI 246 >4U41-A nrPDB Length = 332 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 67/224 (29%), Positives = 106/224 (47%), Gaps = 16/224 (7%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR-EISLLKEL-RHPNIV 64 +E +G GTYG VYKGRH TGQ+ A+K + + +E I+ EI++LK+ H NI Sbjct: 29 VEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE----EEEIKLEINMLKKYSHHRNIA 84 Query: 65 SLQDVLMQ------DSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 + ++ D +L+L+ EF L G + + +IL+G+ Sbjct: 85 TYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAH 144 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG- 177 H V+HRD+K QN+L+ + +KL DFG++ + + T ++ +PEV+ Sbjct: 145 LHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD 204 Query: 178 ---SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 218 A Y D+WS G E+A P + LF I R Sbjct: 205 ENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPR 248 >5HVK-A nrPDB Length = 315 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 107/213 (50%), Gaps = 20/213 (9%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKK-IRLESEEEGVPSTAIREISLLKELRHP 61 D E +G+G +G K H+ TG+V+ MK+ IR + E + T ++E+ +++ L HP Sbjct: 15 DLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQ---RTFLKEVKVMRCLEHP 71 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 N++ VL +D RL I E++ + + QY S V S+ I G+ + HS Sbjct: 72 NVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRV-SFAKDIASGMAYLHS 130 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLA-------------RAFGIPIRVYTHEVV-TL 167 ++HR+L N L+ + + +ADFGLA R+ P R + VV Sbjct: 131 MNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNP 190 Query: 168 WYRSPEVLLGSARYSTPVDIWSIGTIFAELATK 200 ++ +PE++ G + Y VD++S G + E+ + Sbjct: 191 YWMAPEMINGRS-YDEKVDVFSFGIVLCEIIGR 222 >6E2O-A nrPDB Length = 295 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 68/213 (31%), Positives = 106/213 (49%), Gaps = 33/213 (15%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 +G+GTYG+VY GR + +A+K+I P EI+L K L+H NIV Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLH--EEIALHKHLKHKNIVQYLGS 87 Query: 70 LMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKS--------------YLYQILQG 115 ++ + K +++ +P G S+L++S Y QIL+G Sbjct: 88 FSENGFI-----------KIFMEQVPGGSL--SALLRSKWGPLKDNEQTIGFYTKQILEG 134 Query: 116 IVFCHSRRVLHRDLKPQNLLIDD-KGTIKLADFGLA-RAFGIPIRVYTHEVVTLWYRSPE 173 + + H +++HRD+K N+LI+ G +K++DFG + R GI T TL Y +PE Sbjct: 135 LKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETF-TGTLQYMAPE 193 Query: 174 VLLGSAR-YSTPVDIWSIGTIFAELATKKPLFH 205 ++ R Y DIWS+G E+AT KP F+ Sbjct: 194 IIDKGPRGYGKAADIWSLGCTIIEMATGKPPFY 226 >4GS6-A nrPDB Length = 315 Score = 91.3 bits (225), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 76/228 (33%), Positives = 112/228 (49%), Gaps = 22/228 (9%) Query: 1 MEDYTKIEK---IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKE 57 M DY +IE +G G +GVV K + + + VA+K+I ESE + I E+ L Sbjct: 5 MIDYKEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQIESESERKAF----IVELRQLSR 58 Query: 58 LRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 + HPNIV L + + L+ E+ L L P Y ++ S+ Q QG+ Sbjct: 59 VNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGV 116 Query: 117 VFCHS---RRVLHRDLKPQNLLIDDKGTI-KLADFGLARAFGIPIRVYTHEVVTLWYRSP 172 + HS + ++HRDLKP NLL+ GT+ K+ DFG A I + ++ W +P Sbjct: 117 AYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGT--ACDIQTHMTNNKGSAAWM-AP 173 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRAL 220 EV GS YS D++S G I E+ T++ F D FRI A+ Sbjct: 174 EVFEGS-NYSEKCDVFSWGIILWEVITRRKPF--DEIGGPAFRIMWAV 218 >4M7I-A nrPDB Length = 299 Score = 91.3 bits (225), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 109/222 (49%), Gaps = 27/222 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 + D+ I+ +G G +GVV++ ++K A+K+IRL + E +RE+ L +L H Sbjct: 4 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAR-EKVMREVKALAKLEH 62 Query: 61 PNIVSLQDVLMQDS----------RLYLIFEF---LSMDLKKYLDSIPPGQYMDSSLVKS 107 P IV + ++ + ++YL + +LK +++ + + S+ Sbjct: 63 PGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLH 122 Query: 108 YLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG---------IPIR 158 QI + + F HS+ ++HRDLKP N+ +K+ DFGL A P+ Sbjct: 123 IFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMP 182 Query: 159 VY---THEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL 197 Y T +V T Y SPE + G++ YS VDI+S+G I EL Sbjct: 183 AYARHTGQVGTKLYMSPEQIHGNS-YSHKVDIFSLGLILFEL 223 >3ALO-A nrPDB Length = 327 Score = 90.9 bits (224), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 77/295 (26%), Positives = 128/295 (43%), Gaps = 36/295 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ED + +IG G YG V K HK +GQ++A+K+IR +E+ + +++ P Sbjct: 22 EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCP 81 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV---- 117 IV L ++ ++ E +S K+ + +D + + L +I V Sbjct: 82 YIVQFYGALFREGDCWICMELMSTSFDKFYKYV--YSVLDDVIPEEILGKITLATVKALN 139 Query: 118 -FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 + +++HRD+KP N+L+D G IKL DFG++ I T + Y +PE + Sbjct: 140 HLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSI-AKTRDAGCRPYMAPERID 198 Query: 177 GSAR---YSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 SA Y D+WS+G ELAT + P +S DQL ++ + G P Sbjct: 199 PSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK--GDP--------- 247 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 P S + + ++ ++ L D +KR K L HP+ Sbjct: 248 -------------PQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI 289 >4TPT-A nrPDB Length = 303 Score = 90.5 bits (223), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 65/212 (30%), Positives = 106/212 (50%), Gaps = 29/212 (13%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKK-IRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 E +G+G +G K HK TG+V+ MK+ IR + E + T + E+ +++ L HPN++ Sbjct: 6 EVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQ---KTFLTEVKVMRSLDHPNVLKF 62 Query: 67 QDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 125 VL +D +L L+ E++ LK +L S+ P + + I G+ + HS ++ Sbjct: 63 IGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKV---RFAKGIASGMAYLHSMCII 119 Query: 126 HRDLKPQNLLIDDKGTIKLADFGLARAF-----GIPIRVYTHEVVTL------------- 167 HRDL N LI T+ +ADFGL+R P+ T + TL Sbjct: 120 HRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVG 179 Query: 168 --WYRSPEVLLGSARYSTPVDIWSIGTIFAEL 197 ++ +PE+L G + Y VDI+S G + E+ Sbjct: 180 NPYWMAPEMLNGKS-YDETVDIFSFGIVLCEI 210 >5YV8-A nrPDB Length = 298 Score = 90.5 bits (223), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 60/233 (25%), Positives = 115/233 (49%), Gaps = 32/233 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES--------------------- 39 + YT ++IG+G+YGVV ++ AMK + + Sbjct: 12 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 71 Query: 40 ---EEEGVPSTAIREISLLKELRHPNIVSLQDVL--MQDSRLYLIFEFLSMDLKKYLDSI 94 + G +EI++LK+L HPN+V L +VL + LY++FE ++ + ++ Sbjct: 72 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTL 131 Query: 95 PPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG 154 P + + Y +++GI + H ++++HRD+KP NLL+ + G IK+ADFG++ F Sbjct: 132 KP---LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK 188 Query: 155 IPIRVYTHEVVTLWYRSPEVLLGSARY--STPVDIWSIG-TIFAELATKKPLF 204 + ++ V T + +PE L + + +D+W++G T++ + + P Sbjct: 189 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFM 241 >4E93-A nrPDB Length = 377 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 59/198 (29%), Positives = 100/198 (50%), Gaps = 7/198 (3%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ED E+IG G +G V+ GR + +VA+K R E+ + + ++E +LK+ HP Sbjct: 114 EDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCR-ETLPPDLKAKFLQEARILKQYSHP 172 Query: 62 NIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 NIV L V Q +Y++ E + D +L + G + + + G+ + Sbjct: 173 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT--EGARLRVKTLLQMVGDAAAGMEYLE 230 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLAR--AFGIPIRVYTHEVVTLWYRSPEVLLGS 178 S+ +HRDL +N L+ +K +K++DFG++R A G+ V + + +PE L Sbjct: 231 SKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEA-LNY 289 Query: 179 ARYSTPVDIWSIGTIFAE 196 RYS+ D+WS G + E Sbjct: 290 GRYSSESDVWSFGILLWE 307 >3UIU-A nrPDB Length = 306 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 66/225 (29%), Positives = 113/225 (50%), Gaps = 39/225 (17%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D+ +IE IG G +G V+K +H+ G+ +++++ +E+ A RE+ L +L H N Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEK------AEREVKALAKLDHVN 66 Query: 63 IV------------------SLQ--DVLMQDSR---------LYLIFEFLSM-DLKKYLD 92 IV SL+ D ++S+ L++ EF L+++++ Sbjct: 67 IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIE 126 Query: 93 SIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARA 152 G+ +D L QI +G+ + HS++++HRDLKP N+ + D +K+ DFGL + Sbjct: 127 K-RRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTS 185 Query: 153 FGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL 197 + T TL Y SPE + S Y VD++++G I AEL Sbjct: 186 LKNDGK-RTRSKGTLRYMSPE-QISSQDYGKEVDLYALGLILAEL 228 >3KN6-A nrPDB Length = 325 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 75/274 (27%), Positives = 122/274 (44%), Gaps = 36/274 (13%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKI--RLESEEEGVPSTAIREISLLKELR-HPNIVSL 66 +GEG++ + K HK + Q A+K I R+E+ + +EI+ LK HPNIV L Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQ-------KEITALKLCEGHPNIVKL 71 Query: 67 QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 +V +L+ E L+ + + I ++ + + +++ + H V+H Sbjct: 72 HEVFHDQLHTFLVMELLNGG--ELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVH 129 Query: 127 RDLKPQNLLIDDKG---TIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYST 183 RDLKP+NLL D+ IK+ DFG AR + TL Y +PE LL Y Sbjct: 130 RDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE-LLNQNGYDE 188 Query: 184 PVDIWSIGTI-FAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 D+WS+G I + L+ + P D + T E+ +++ D+ Sbjct: 189 SCDLWSLGVILYTMLSGQVPFQSHDRSL---------TCTSAVEIMKKIKK-GDFSFEGE 238 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI 276 W KN+ + DL+ +L DP KR+ Sbjct: 239 AW---------KNVSQEAKDLIQGLLTVDPNKRL 263 >6NPU-A nrPDB Length = 298 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 58/199 (29%), Positives = 104/199 (52%), Gaps = 7/199 (3%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D T K+G G YG VY+G K VA+K ++ ++ E ++E +++KE++HPN Sbjct: 27 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---VEEFLKEAAVMKEIKHPN 83 Query: 63 IVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +V L V ++ Y+I EF++ +L YL Q +++ ++ QI + + Sbjct: 84 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNR-QEVNAVVLLYMATQISSAMEYLEK 142 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEVVTLWYRSPEVLLGSAR 180 + +HRDL +N L+ + +K+ADFGL+R G + + + +PE L + Sbjct: 143 KNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES-LAYNK 201 Query: 181 YSTPVDIWSIGTIFAELAT 199 +S D+W+ G + E+AT Sbjct: 202 FSIKSDVWAFGVLLWEIAT 220 >5TQX-A nrPDB Length = 655 Score = 89.7 bits (221), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 86/282 (30%), Positives = 131/282 (46%), Gaps = 27/282 (9%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 E++G G +G V +H+ +A+K RLE + EI ++K+L H N+V Sbjct: 14 ERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWC-HEIQIMKKLNHANVVKAC 72 Query: 68 DV------LMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 DV L+ D L L E+ S DL+K L+ + S + S L I GI + H Sbjct: 73 DVPEELNILIHDVPL-LAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLH 131 Query: 121 SRRVLHRDLKPQNLLIDDKG---TIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 +++HRDLKP+N+++ D G K+ D G A+ + T V TL Y +PE L Sbjct: 132 ENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQG-ELCTEFVGTLQYLAPE-LFE 189 Query: 178 SARYSTPVDIWSIGT-IFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 236 + Y+ VD WS GT +F +A +P H Q F + + + E + Sbjct: 190 NKPYTATVDYWSFGTMVFECIAGYRPFLHH----LQPFTWHEKIKKKDPKCIFACEEMSG 245 Query: 237 ---YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKR 275 + + P +P SL S + EN L L ML +DP +R Sbjct: 246 EVRFSSHLP--QPNSLCSLIVEPMENWLQL---MLNWDPQQR 282 >3VN9-A nrPDB Length = 340 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 61/205 (29%), Positives = 107/205 (52%), Gaps = 12/205 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIR--LESEEEGVPSTAIREISL-LKEL 58 +D I ++G G YGVV K RH +GQ++A+K+IR + S+E+ + ++ + ++ + Sbjct: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ---KRLLMDLDISMRTV 107 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKK-YLDSIPPGQYMDSSLVKSYLYQILQGIV 117 P V+ L ++ +++ E + L K Y I GQ + ++ I++ + Sbjct: 108 DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 167 Query: 118 FCHSR-RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL- 175 HS+ V+HRD+KP N+LI+ G +K+ DFG++ + + T + Y +PE + Sbjct: 168 HLHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS-GYLVDSVAKTIDAGCKPYMAPERIN 226 Query: 176 --LGSARYSTPVDIWSIGTIFAELA 198 L YS DIWS+G ELA Sbjct: 227 PELNQKGYSVKSDIWSLGITMIELA 251 >5UNP-A nrPDB Length = 369 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 92/338 (27%), Positives = 139/338 (41%), Gaps = 65/338 (19%) Query: 2 EDYTKIEKIGEGTYG-VVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 E Y + +GEGT+G VV H+ G VA+K I+ E A EI++L+++ Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK---NVEKYKEAARLEINVLEKINE 90 Query: 61 PN------IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSL--VKSYLYQI 112 + V + D + + FE L + D + Y+ + V+ +Q+ Sbjct: 91 KDPDNKNLCVQMFDWFDYHGHMCISFELLGLST---FDFLKDNNYLPYPIHQVRHMAFQL 147 Query: 113 LQGIVFCHSRRVLHRDLKPQNLLI---------------DDKG----TIKLADFGLARAF 153 Q + F H ++ H DLKP+N+L D++ +++ DFG A Sbjct: 148 CQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA--- 204 Query: 154 GIPIRVYTHE-----VVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDS 208 + HE V T YR+PEV+L +S P D+WSIG I E LF Sbjct: 205 -----TFDHEHHSTIVSTRHYRAPEVILELG-WSQPCDVWSIGCIIFEYYVGFTLFQTHD 258 Query: 209 EIDQLFRIFRALG-TPNNEV---------------WPEVESLQDYKNTFPKWKPGSLASH 252 + L + R LG P+ + W E S Y K L S Sbjct: 259 NREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSE 318 Query: 253 VKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 + DL+ ML Y+PAKR++ AL HP+F L Sbjct: 319 AEE-HHQLFDLIESMLEYEPAKRLTLGEALQHPFFARL 355 >4XEY-B nrPDB Length = 408 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 58/199 (29%), Positives = 104/199 (52%), Gaps = 7/199 (3%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D T K+G G YG VY+G K VA+K ++ ++ E ++E +++KE++HPN Sbjct: 126 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---VEEFLKEAAVMKEIKHPN 182 Query: 63 IVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +V L V ++ Y+I EF++ +L YL Q +++ ++ QI + + Sbjct: 183 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNR-QEVNAVVLLYMATQISSAMEYLEK 241 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEVVTLWYRSPEVLLGSAR 180 + +HRDL +N L+ + +K+ADFGL+R G + + + +PE L + Sbjct: 242 KNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES-LAYNK 300 Query: 181 YSTPVDIWSIGTIFAELAT 199 +S D+W+ G + E+AT Sbjct: 301 FSIKSDVWAFGVLLWEIAT 319 >2HW6-A nrPDB Length = 307 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 80/303 (26%), Positives = 131/303 (43%), Gaps = 31/303 (10%) Query: 1 MEDYTKI--EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL 58 ED K+ E +GEG Y V G+ A+K I E + S RE+ L + Sbjct: 10 FEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQC 67 Query: 59 R-HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 + + NI+ L + D+R YL+FE L L I ++ + + + + Sbjct: 68 QGNKNILELIEFFEDDTRFYLVFEKLQGG--SILAHIQKQKHFNEREASRVVRDVAAALD 125 Query: 118 FCHSRRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGI-----PIRV--YTHEVVTL 167 F H++ + HRDLKP+N+L + +K+ DF L + PI T + Sbjct: 126 FLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA 185 Query: 168 WYRSPEVLL----GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTP 223 Y +PEV+ + Y D+WS+G + + + P F G D + Sbjct: 186 EYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVC 245 Query: 224 NNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 N+++ ES+Q+ K FP ++S K DL+SK+L+ D +R+S L Sbjct: 246 QNKLF---ESIQEGKYEFPDKDWAHISSEAK-------DLISKLLVRDAKQRLSAAQVLQ 295 Query: 284 HPY 286 HP+ Sbjct: 296 HPW 298 >4KIK-B nrPDB Length = 677 Score = 89.0 bits (219), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 61/202 (30%), Positives = 102/202 (50%), Gaps = 13/202 (6%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 E++G G +G V + ++ TG+ +A+K+ R E + EI +++ L HPN+V+ + Sbjct: 25 ERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL-EIQIMRRLTHPNVVAAR 83 Query: 68 DV------LMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 DV L + L E+ DL+KYL+ + + + L I + + H Sbjct: 84 DVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLH 143 Query: 121 SRRVLHRDLKPQNLLI---DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 R++HRDLKP+N+++ + + K+ D G A+ + T V TL Y +PE LL Sbjct: 144 ENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQG-SLCTSFVGTLQYLAPE-LLE 201 Query: 178 SARYSTPVDIWSIGTIFAELAT 199 +Y+ VD WS GT+ E T Sbjct: 202 QQKYTVTVDYWSFGTLAFECIT 223 >2JDO-A nrPDB Length = 342 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 80/304 (26%), Positives = 143/304 (47%), Gaps = 48/304 (15%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES--EEEGVPSTAIREISLLKEL 58 M D+ ++ +G+GT+G V R K TG+ AMK +R E ++ V T + E +L+ Sbjct: 9 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHT-VTESRVLQNT 67 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 RHP + +L+ RL + E+ + + + + + Y +I+ + + Sbjct: 68 RHPFLTALKYAFQTHDRLCFVMEYANG--GELFFHLSRERVFTEERARFYGAEIVSALEY 125 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLAR---AFGIPIRVYTHEVVTLWYRSPEVL 175 HSR V++RD+K +NL++D G IK+ DFGL + + G ++ + T Y +PEVL Sbjct: 126 LHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCG---TPEYLAPEVL 182 Query: 176 LGSARYSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 + Y VD W +G + E+ + P ++ D E R+F + + E+ Sbjct: 183 EDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHE-----RLFELI------LMEEIR-- 228 Query: 235 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG-----KMALNHPYFND 289 FP+ +L+ K+ LL+ +L DP +R+ G K + H +F Sbjct: 229 ------FPR----TLSPEAKS-------LLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLS 271 Query: 290 LDNQ 293 ++ Q Sbjct: 272 INWQ 275 >6FYV-A nrPDB Length = 337 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 92/327 (28%), Positives = 137/327 (41%), Gaps = 51/327 (15%) Query: 4 YTKIEKIGEGTYG-VVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR-EISLLKELRH- 60 Y ++ +GEG +G VV H G VA+K ++ G A R EI +L+ L Sbjct: 16 YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVK----NVGRYREAARSEIQVLEHLNST 71 Query: 61 -PN----IVSLQDVLMQDSRLYLIFEFLSMDLKKYL--DSIPPGQYMDSSLVKSYLYQIL 113 PN V + + + ++FE L + ++ +S P Q ++ YQI Sbjct: 72 DPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQI---DHIRQMAYQIC 128 Query: 114 QGIVFCHSRRVLHRDLKPQNLLI--------------DDKGTIKLADFGLARAFGIPIRV 159 Q I F H ++ H DLKP+N+L D+ T+K D + FG Sbjct: 129 QSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVV-DFGSATYD 187 Query: 160 YTHE---VVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRI 216 H V T YR+PEV+L +S P D+WSIG I E +F + L + Sbjct: 188 DEHHSTLVSTRHYRAPEVILALG-WSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMM 246 Query: 217 FRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLAS-----HVKNLDENGL---------- 261 R LG + + + + + W S A K L E L Sbjct: 247 ERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLF 306 Query: 262 DLLSKMLIYDPAKRISGKMALNHPYFN 288 DL+ +ML YDP +RI+ AL HP+F+ Sbjct: 307 DLVRRMLEYDPTQRITLDEALQHPFFD 333 >6ED6-A nrPDB Length = 415 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 72/261 (27%), Positives = 112/261 (42%), Gaps = 28/261 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRH 60 EDY ++ IG G +G V RHK + +V AMK + + E + + E ++ Sbjct: 88 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 147 Query: 61 PNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 P +V L D LY++ E++ DL + + + K Y +++ + Sbjct: 148 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD----VPEKWAKFYTAEVVLALDAI 203 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEVLL-- 176 HS ++HRD+KP N+L+D G +KLADFG V+ V T Y SPEVL Sbjct: 204 HSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQ 263 Query: 177 -GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 G Y D WS+G E+ F+ DS + +I Sbjct: 264 GGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM------------------ 305 Query: 236 DYKNTFPKWKPGSLASHVKNL 256 D+KN+ + ++ H KNL Sbjct: 306 DHKNSLCFPEDAEISKHAKNL 326 >2Z7Q-A nrPDB Length = 321 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 68/221 (30%), Positives = 111/221 (50%), Gaps = 11/221 (4%) Query: 10 IGEGTYGVVYKGRHKT---TGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 +G+G++G V+ R T +G + AMK ++ + + E +L ++ HP +V L Sbjct: 36 LGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKL 95 Query: 67 QDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 125 + +LYLI +FL DL + VK YL ++ G+ HS ++ Sbjct: 96 HYAFQTEGKLYLILDFLRGGDL---FTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGII 152 Query: 126 HRDLKPQNLLIDDKGTIKLADFGLAR-AFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTP 184 +RDLKP+N+L+D++G IKL DFGL++ A + Y+ T+ Y +PEV + +S Sbjct: 153 YRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSF-CGTVEYMAPEV-VNRQGHSHS 210 Query: 185 VDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA-LGTPN 224 D WS G + E+ T F G + + I +A LG P Sbjct: 211 ADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQ 251 >5VD3-A nrPDB Length = 311 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 65/216 (30%), Positives = 104/216 (48%), Gaps = 12/216 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLL----KE 57 + + ++ ++G G+YG V+K R K G++ A+K R S G P R+++ + K Sbjct: 57 QSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVK--RSMSPFRG-PKDRARKLAEVGSHEKV 113 Query: 58 LRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 +HP V L+ + LYL E L+++ ++ G + + V YL L + Sbjct: 114 GQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAW--GASLPEAQVWGYLRDTLLALA 171 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 HS+ ++H D+KP N+ + +G KL DFGL G E Y +PE+L G Sbjct: 172 HLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPR-YMAPELLQG 230 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQL 213 S Y T D++S+G E+A L HG QL Sbjct: 231 S--YGTAADVFSLGLTILEVACNMELPHGGEGWQQL 264 >6CKI-A nrPDB Length = 316 Score = 88.2 bits (217), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 83/305 (27%), Positives = 139/305 (45%), Gaps = 35/305 (11%) Query: 1 MEDYTKIEK--IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL 58 ED ++++ +GEG + V + T Q A+K I E + + S RE+ +L + Sbjct: 10 FEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKII--EKQPGHIRSRVFREVEMLYQC 67 Query: 59 R-HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 + H N++ L + ++ R YL+FE M L I ++ + + + + Sbjct: 68 QGHRNVLELIEFFEEEDRFYLVFE--KMRGGSILSHIHKRRHFNELEASVVVQDVASALD 125 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGT---IKLADFGLARAF---GIPIRVYTHEVVTLW--- 168 F H++ + HRDLKP+N+L + +K+ DFGL G + T E++T Sbjct: 126 FLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSA 185 Query: 169 -YRSPEVLLG----SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTP 223 Y +PEV+ ++ Y D+WS+G I L + P F G D + A Sbjct: 186 EYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPAC 245 Query: 224 NNEVWPEVESLQDYKNTFP--KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 N ++ ES+Q+ K FP W S A+ DL+SK+L+ D +R+S Sbjct: 246 QNMLF---ESIQEGKYEFPDKDWAHISCAAK---------DLISKLLVRDAKQRLSAAQV 293 Query: 282 LNHPY 286 L HP+ Sbjct: 294 LQHPW 298 >2FO0-A nrPDB Length = 495 Score = 88.2 bits (217), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 57/199 (28%), Positives = 104/199 (52%), Gaps = 7/199 (3%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D T K+G G YG VY+G K VA+K ++ ++ E ++E +++KE++HPN Sbjct: 218 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---VEEFLKEAAVMKEIKHPN 274 Query: 63 IVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +V L V ++ Y+I EF++ +L YL Q +++ ++ QI + + Sbjct: 275 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNR-QEVNAVVLLYMATQISSAMEYLEK 333 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEVVTLWYRSPEVLLGSAR 180 + +HR+L +N L+ + +K+ADFGL+R G + + + +PE L + Sbjct: 334 KNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES-LAYNK 392 Query: 181 YSTPVDIWSIGTIFAELAT 199 +S D+W+ G + E+AT Sbjct: 393 FSIKSDVWAFGVLLWEIAT 411 >3LM0-A nrPDB Length = 327 Score = 87.8 bits (216), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 71/289 (24%), Positives = 129/289 (44%), Gaps = 33/289 (11%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH-PNIVSL 66 +++G G + VV + K+TGQ A K ++ + + + EI++L+ + P +++L Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINL 94 Query: 67 QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 +V S + LI E+ + L + + + V + QIL+G+ + H ++H Sbjct: 95 HEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVH 154 Query: 127 RDLKPQNLLIDD---KGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEVLLGSARYS 182 DLKPQN+L+ G IK+ DFG++R G + E++ T Y +PE+ L + Sbjct: 155 LDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACEL--REIMGTPEYLAPEI-LNYDPIT 211 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 T D+W+IG I L T F G+ + I + + E + V L Sbjct: 212 TATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQL-------- 263 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 D + +L+ +P KR + ++ L+H + D Sbjct: 264 -----------------ATDFIQSLLVKNPEKRPTAEICLSHSWLQQWD 295 >1TKI-A nrPDB Length = 321 Score = 87.8 bits (216), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 69/292 (23%), Positives = 138/292 (47%), Gaps = 41/292 (14%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E Y E +G G +G+V++ ++ + K ++++ ++ + +EIS+L RH Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVK---KEISILNIARHR 61 Query: 62 NIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 NI+ L + L +IFEF+S +D+ + +++ ++ + SY++Q+ + + F H Sbjct: 62 NILHLHESFESMEELVMIFEFISGLDIFERINT--SAFELNEREIVSYVHQVCEALQFLH 119 Query: 121 SRRVLHRDLKPQNLLIDDK--GTIKLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVLL 176 S + H D++P+N++ + TIK+ +FG AR G R+ Y +PEV Sbjct: 120 SHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLL---FTAPEYYAPEVHQ 176 Query: 177 GSARYSTPVDIWSIGT-IFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 ST D+WS+GT ++ L+ P L N ++ +E++ Sbjct: 177 HDV-VSTATDMWSLGTLVYVLLSGINPF----------------LAETNQQI---IENIM 216 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 + + TF + K + +D + ++L+ + R++ AL HP+ Sbjct: 217 NAEYTFDE-------EAFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWL 261 >5UIU-A nrPDB Length = 323 Score = 87.0 bits (214), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 68/204 (33%), Positives = 101/204 (49%), Gaps = 19/204 (9%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIR--LESEEEGVPSTAIREISLLKELRHPNIVSL 66 K+GEG +GVVYKG T VA+KK+ ++ E + +EI ++ + +H N+V L Sbjct: 54 KMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 111 Query: 67 QDVLMQDSRLYLIFEFLS----MDLKKYLDSIPP-GQYMDSSLVKSYLYQILQGIVFCHS 121 L L++ ++ +D LD PP +M + + GI F H Sbjct: 112 LGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQG----AANGINFLHE 167 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEVV-TLWYRSPEVLLGSA 179 +HRD+K N+L+D+ T K++DFGLARA V T +V T Y +PE L G Sbjct: 168 NHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI 227 Query: 180 RYSTP-VDIWSIGTIFAELATKKP 202 TP DI+S G + E+ T P Sbjct: 228 ---TPKSDIYSFGVVLLEIITGLP 248 >1ZXE-A nrPDB Length = 303 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 63/223 (28%), Positives = 104/223 (46%), Gaps = 33/223 (14%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP- 61 D+ +I +G+G +G V K R+ + A+KKIR E+ ST + E+ LL L H Sbjct: 7 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEK---LSTILSEVMLLASLNHQY 63 Query: 62 ------------NIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSY 108 N V + + S L++ E+ + L + S Q D Sbjct: 64 VVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYW--RL 121 Query: 109 LYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV--------- 159 QIL+ + + HS+ ++HR+LKP N+ ID+ +K+ DFGLA+ + + Sbjct: 122 FRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLP 181 Query: 160 -----YTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL 197 T + T Y + EVL G+ Y+ +D++S+G IF E+ Sbjct: 182 GSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEM 224 >4RA4-A nrPDB Length = 355 Score = 86.3 bits (212), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 71/302 (23%), Positives = 140/302 (46%), Gaps = 47/302 (15%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES--EEEGVPSTAIREISLLKEL 58 + D+ + +G+G++G V K T ++ A+K ++ + +++ V T + + L Sbjct: 19 LTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLD 78 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 + P + L RLY + E+++ DL ++ + G++ + V Y +I G+ Sbjct: 79 KPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQV--GKFKEPQAV-FYAAEISIGLF 135 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF---GIPIRVYTHEVVTLWYRSPEV 174 F H R +++RDLK N+++D +G IK+ADFG+ + G+ R + T Y +PE+ Sbjct: 136 FLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCG---TPDYIAPEI 192 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 + Y VD W+ G + E+ +P F G+ E D+LF +S+ Sbjct: 193 -IAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDE-DELF-----------------QSI 233 Query: 235 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG-----KMALNHPYFND 289 ++ ++P K+L + + + ++ PAKR+ + H +F Sbjct: 234 MEHNVSYP-----------KSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRR 282 Query: 290 LD 291 +D Sbjct: 283 ID 284 >3FME-A nrPDB Length = 290 Score = 86.3 bits (212), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 60/205 (29%), Positives = 106/205 (51%), Gaps = 12/205 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIR--LESEEEGVPSTAIREISL-LKEL 58 +D I ++G G YGVV K RH +GQ++A+K+IR + S+E+ + ++ + ++ + Sbjct: 7 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ---KRLLMDLDISMRTV 63 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKK-YLDSIPPGQYMDSSLVKSYLYQILQGIV 117 P V+ L ++ +++ E + L K Y I GQ + ++ I++ + Sbjct: 64 DCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALE 123 Query: 118 FCHSR-RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL- 175 HS+ V+HRD+KP N+LI+ G +K+ DFG++ + + + Y +PE + Sbjct: 124 HLHSKLSVIHRDVKPSNVLINALGQVKMCDFGIS-GYLVDDVAKDIDAGCKPYMAPERIN 182 Query: 176 --LGSARYSTPVDIWSIGTIFAELA 198 L YS DIWS+G ELA Sbjct: 183 PELNQKGYSVKSDIWSLGITMIELA 207 >6E9W-A nrPDB Length = 443 Score = 86.3 bits (212), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 71/245 (28%), Positives = 111/245 (45%), Gaps = 18/245 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRH 60 EDY ++ IG G +G V RHK+T +V AMK + + E + + E ++ Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 161 Query: 61 PNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDS--IPPGQYMDSSLVKSYLYQILQGIV 117 P +V L D LY++ E++ DL + + +P + Y +++ + Sbjct: 162 PWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVP------EKWARFYTAEVVLALD 215 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEVLL 176 HS +HRD+KP N+L+D G +KLADFG V V T Y SPEVL Sbjct: 216 AIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLK 275 Query: 177 ---GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIF---RALGTP-NNEVWP 229 G Y D WS+G E+ F+ DS + +I +L P +N++ Sbjct: 276 SQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISK 335 Query: 230 EVESL 234 E ++L Sbjct: 336 EAKNL 340 >4C0T-A nrPDB Length = 974 Score = 85.5 bits (210), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 65/218 (29%), Positives = 103/218 (47%), Gaps = 14/218 (6%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI--RLESEEEGVPSTAIREISLLKELRH 60 D+ +++GEG+Y V K TG+ A+K + R +E+ V I + +L + Sbjct: 267 DFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNR 326 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 ++SL LY + ++ S + L I ++ + + QIL I + H Sbjct: 327 LGVISLYFTFQDKDSLYFVLDYASNG--ELLTLIKRYNTLNEECTRHFGAQILDAIKYMH 384 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLAR--------AFGIPIRVYTHEVV-TLWYRS 171 V+HRDLKP+N+L+DDK I++ DFG AR + P+ V V T Y S Sbjct: 385 DNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVS 444 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSE 209 PE LL + P D+W+ G I ++ KP F +E Sbjct: 445 PE-LLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNE 481 >5D9K-A nrPDB Length = 330 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 71/232 (30%), Positives = 117/232 (50%), Gaps = 14/232 (6%) Query: 10 IGEGTYGVVYKGRHKTTG----QVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVS 65 +G+G++G V+ + K +G Q+ AMK ++ + + E +L E+ HP IV Sbjct: 38 LGQGSFGKVFLVK-KISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVK 96 Query: 66 LQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 124 L + +LYLI +FL DL + VK YL ++ + HS + Sbjct: 97 LHYAFQTEGKLYLILDFLRGGDL---FTRLSKEVMFTEEDVKFYLAELALALDHLHSLGI 153 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLAR-AFGIPIRVYTHEVVTLWYRSPEVLLGSARYST 183 ++RDLKP+N+L+D++G IKL DFGL++ + + Y+ T+ Y +PEV + ++ Sbjct: 154 IYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSF-CGTVEYMAPEV-VNRRGHTQ 211 Query: 184 PVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA-LGTPNNEVWPEVESL 234 D WS G + E+ T F G + + I +A LG P + PE +SL Sbjct: 212 SADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQF-LSPEAQSL 262 >3ORZ-A nrPDB Length = 316 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 78/300 (26%), Positives = 134/300 (44%), Gaps = 45/300 (15%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI--RLESEEEGVPSTAIREISLLKELR 59 ED+ + +GEG++ V R T + A+K + R +E VP RE ++ L Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVT-RERDVMSRLD 95 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 HP V L D +LY + + +L KY+ I G + D + + Y +I+ + + Sbjct: 96 HPFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKI--GSF-DETCTRFYTAEIVSALEY 152 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHE--VVTLWYRSPEVLL 176 H + ++HRDLKP+N+L+++ I++ DFG A+ + V T Y SPE+L Sbjct: 153 LHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT 212 Query: 177 GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 236 + + D+W++G I +L P F +E + IF+ + + +PE Sbjct: 213 EKSACKSS-DLWALGCIIYQLVAGLPPFRAGNE----YLIFQKIIKLEYD-FPE------ 260 Query: 237 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN------HPYFNDL 290 FPK + DL+ K+L+ D KR+ + HP+F + Sbjct: 261 --KFFPKAR----------------DLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 302 >5VO2-A nrPDB Length = 300 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 57/199 (28%), Positives = 97/199 (48%), Gaps = 15/199 (7%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 E+ ++ +G G G V+ GR G+ VA+KK+R E +I L++L+H Sbjct: 11 FEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKE---------TDIKHLRKLKH 59 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNI++ + V Q ++ EF + + + + G+ + SL+ + I G+ + H Sbjct: 60 PNIITFKGVCTQAPCYCILMEFCAQG--QLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLH 117 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 +++HRDLK N+LI +K++DFG ++ + W +PEV+ Sbjct: 118 LHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWM-APEVIRNEP- 175 Query: 181 YSTPVDIWSIGTIFAELAT 199 S VDIWS G + EL T Sbjct: 176 VSEKVDIWSFGVVLWELLT 194 >3GQL-A nrPDB Length = 326 Score = 84.3 bits (207), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 74/278 (26%), Positives = 139/278 (50%), Gaps = 36/278 (12%) Query: 10 IGEGTYGVVYKGR---------HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-R 59 +GEG +G V ++ T VA+K ++ ++ E+ + S I E+ ++K + + Sbjct: 36 LGEGAFGQVVLAEAIGLDKDKPNRVTK--VAVKMLKSDATEKDL-SDLISEMEMMKMIGK 92 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSI-PPG------------QYMDSSLV 105 H NI++L QD LY+I E+ S +L++YL + PPG + + S + Sbjct: 93 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 152 Query: 106 KSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY---TH 162 S YQ+ +G+ + S++ +HRDL +N+L+ + +K+ADFGLAR I Y T+ Sbjct: 153 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH-HIDYYKKTTN 211 Query: 163 EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA--- 219 + + + +PE L Y+ D+WS G + E+ T + +++LF++ + Sbjct: 212 GRLPVKWMAPEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHR 270 Query: 220 LGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLD 257 + P+N ++D + P +P + V++LD Sbjct: 271 MDKPSNCTNELYMMMRDCWHAVPSQRP-TFKQLVEDLD 307 >3RAW-A nrPDB Length = 381 Score = 84.3 bits (207), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 94/338 (27%), Positives = 144/338 (42%), Gaps = 65/338 (19%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQV-VAMKKIRLESEEEGVPSTAIR-EISLLKELR 59 E Y + +GEGT+G V + G+ VA+K IR G A R EI++LK+++ Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIR----NVGKYREAARLEINVLKKIK 106 Query: 60 HPN------IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQIL 113 + V + D + + FE L + ++L Y V+ YQ+ Sbjct: 107 EKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPY-PLPHVRHMAYQLC 165 Query: 114 QGIVFCHSRRVLHRDLKPQNLL---------------IDDKG----TIKLADFGLARAFG 154 + F H ++ H DLKP+N+L ++K +I++ADFG A Sbjct: 166 HALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA---- 221 Query: 155 IPIRVYTHE-----VVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSE 209 + HE V T YR PEV+L ++ P D+WSIG I E LF Sbjct: 222 ----TFDHEHHTTIVATRHYRPPEVILELG-WAQPCDVWSIGCILFEYYRGFTLFQTHEN 276 Query: 210 IDQLFRIFRALG-TPNNE---------------VWPEVESLQDY-KNTFPKWKPGSLASH 252 + L + + LG P++ VW E S Y K K L Sbjct: 277 REHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDS 336 Query: 253 VKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 ++++ DL+ +ML +DPA+RI+ AL HP+F L Sbjct: 337 LEHV--QLFDLMRRMLEFDPAQRITLAEALLHPFFAGL 372 >3TT0-A nrPDB Length = 382 Score = 84.3 bits (207), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 68/249 (27%), Positives = 129/249 (51%), Gaps = 25/249 (10%) Query: 30 VAMKKIRLESEEEGVPSTAIREISLLKEL-RHPNIVSLQDVLMQDSRLYLIFEFLSM-DL 87 VA+K ++ ++ E+ + S I E+ ++K + +H NI++L QD LY+I E+ S +L Sbjct: 104 VAVKMLKSDATEKDL-SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNL 162 Query: 88 KKYLDSI-PPG------------QYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNL 134 ++YL + PPG + + S + S YQ+ +G+ + S++ +HRDL +N+ Sbjct: 163 REYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 222 Query: 135 LIDDKGTIKLADFGLARAFGIPIRVY---THEVVTLWYRSPEVLLGSARYSTPVDIWSIG 191 L+ + +K+ADFGLAR I Y T+ + + + +PE L Y+ D+WS G Sbjct: 223 LVTEDNVMKIADFGLARDIH-HIDYYKKTTNGRLPVKWMAPEALFDRI-YTHQSDVWSFG 280 Query: 192 TIFAELATKKPLFHGDSEIDQLFRIFRA---LGTPNNEVWPEVESLQDYKNTFPKWKPGS 248 + E+ T + +++LF++ + + P+N ++D + P +P + Sbjct: 281 VLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRP-T 339 Query: 249 LASHVKNLD 257 V++LD Sbjct: 340 FKQLVEDLD 348 >5A46-A nrPDB Length = 386 Score = 84.0 bits (206), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 74/278 (26%), Positives = 139/278 (50%), Gaps = 36/278 (12%) Query: 10 IGEGTYGVVYKGR---------HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-R 59 +GEG +G V ++ T VA+K ++ ++ E+ + S I E+ ++K + + Sbjct: 48 LGEGCFGQVVLAEAIGLDKDKPNRVTK--VAVKMLKSDATEKDL-SDLISEMEMMKMIGK 104 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSI-PPG------------QYMDSSLV 105 H NI++L QD LY+I E+ S +L++YL + PPG + + S + Sbjct: 105 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 164 Query: 106 KSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY---TH 162 S YQ+ +G+ + S++ +HRDL +N+L+ + +K+ADFGLAR I Y T+ Sbjct: 165 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHH-IDYYKKTTN 223 Query: 163 EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA--- 219 + + + +PE L Y+ D+WS G + E+ T + +++LF++ + Sbjct: 224 GRLPVKWMAPEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHR 282 Query: 220 LGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLD 257 + P+N ++D + P +P + V++LD Sbjct: 283 MDKPSNCTNELYMMMRDCWHAVPSQRP-TFKQLVEDLD 319 >4UY9-A nrPDB Length = 323 Score = 83.6 bits (205), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 77/275 (28%), Positives = 129/275 (46%), Gaps = 32/275 (11%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE--GVPSTAIREISLLKELRHPNIVS 65 E IG G +G VY R G VA+K R + +E+ +E L L+HPNI++ Sbjct: 15 EIIGIGGFGKVY--RAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIA 72 Query: 66 LQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR-- 123 L+ V +++ L L+ EF L+ + G+ + ++ ++ QI +G+ + H Sbjct: 73 LRGVCLKEPNLCLVMEFAR---GGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIV 129 Query: 124 -VLHRDLKPQNLLIDDK--------GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 ++HRDLK N+LI K +K+ DFGLAR + ++ T + +PEV Sbjct: 130 PIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA--AGTYAWMAPEV 187 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR------ALGTPNNEVW 228 + S +S D+WS G + EL T + F G ID L + AL P+ Sbjct: 188 IRASM-FSKGSDVWSYGVLLWELLTGEVPFRG---IDGLAVAYGVAMNKLALPIPSTCPE 243 Query: 229 PEVESLQDYKNTFPKWKPG--SLASHVKNLDENGL 261 P + ++D N P +P ++ + ++E+G Sbjct: 244 PFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGF 278 >6CCF-A nrPDB Length = 290 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 62/233 (26%), Positives = 111/233 (47%), Gaps = 32/233 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-----------------RLESEEEG 43 + Y +IG+G YGVV +++ + AMK + R +G Sbjct: 4 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQG 63 Query: 44 VPSTAI-------REISLLKELRHPNIVSLQDVL--MQDSRLYLIFEFLSMDLKKYLDSI 94 P+ + +EI++LK+L H N+V L +VL + LYL+F+ L K + + Sbjct: 64 GPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLR---KGPVMEV 120 Query: 95 PPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG 154 P + + YL ++ G+ + H ++++HRD+KP NLL+ D G +K+ADFG++ F Sbjct: 121 PCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 180 Query: 155 IPIRVYTHEVVTLWYRSPEVL--LGSARYSTPVDIWSIG-TIFAELATKKPLF 204 + T + +PE + G + +D+W+ G T++ + K P Sbjct: 181 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFI 233 >4FR4-A nrPDB Length = 384 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 70/290 (24%), Positives = 133/290 (45%), Gaps = 35/290 (12%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPNIVS 65 + IG+G++G V + T ++ AMK + + + E +E+ +++ L HP +V+ Sbjct: 20 LRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPFLVN 79 Query: 66 LQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 124 L + ++++ + L DL+ +L + VK ++ +++ + + ++R+ Sbjct: 80 LWYSFQDEEDMFMVVDLLLGGDLRYHLQQ---NVHFKEETVKLFICELVMALDYLQNQRI 136 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG--SARYS 182 +HRD+KP N+L+D+ G + + DF +A ++ T T Y +PE+ A YS Sbjct: 137 IHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTM-AGTKPYMAPEMFSSRKGAGYS 195 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 VD WS+G EL + +H S T + E+ V + + T+P Sbjct: 196 FAVDWWSLGVTAYELLRGRRPYHIRS------------STSSKEI---VHTFETTVVTYP 240 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMAL-NHPYFNDLD 291 + S LL K+L +P +R S + N PY ND++ Sbjct: 241 SAWSQEMVS-----------LLKKLLEPNPDQRFSQLSDVQNFPYMNDIN 279 >3ZZW-A nrPDB Length = 289 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 73/266 (27%), Positives = 130/266 (48%), Gaps = 30/266 (11%) Query: 7 IEKIGEGTYGVVYKGR-----HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLK-ELRH 60 +E++GE +G VYKG Q VA+K L+ + EG R ++L+ L+H Sbjct: 14 MEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKT--LKDKAEGPLREEFRHEAMLRARLQH 71 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPP----GQYMDSSLVKSYL------ 109 PN+V L V+ +D L +IF + S DL ++L P G D VKS L Sbjct: 72 PNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFV 131 Query: 110 ---YQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP--IRVYTHEV 164 QI G+ + S V+H+DL +N+L+ DK +K++D GL R ++ + + Sbjct: 132 HLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSL 191 Query: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT---KKPLFHGDSEIDQLFRIFRALG 221 + + + +PE ++ ++S DIWS G + E+ + + + + ++ ++ R + L Sbjct: 192 LPIRWMAPEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLP 250 Query: 222 TPNN-EVWPEVESLQDYKNTFPKWKP 246 P++ W ++ + N FP +P Sbjct: 251 CPDDCPAWVYALMIECW-NEFPSRRP 275 >2PSQ-A nrPDB Length = 370 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 72/276 (26%), Positives = 134/276 (48%), Gaps = 32/276 (11%) Query: 10 IGEGTYGVVYKGR-------HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHP 61 +GEG +G V VA+K ++ ++ E+ + S + E+ ++K + +H Sbjct: 89 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL-SDLVSEMEMMKMIGKHK 147 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSI-PPG------------QYMDSSLVKS 107 NI++L QD LY+I E+ S +L++YL + PPG + M + S Sbjct: 148 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVS 207 Query: 108 YLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY---THEV 164 YQ+ +G+ + S++ +HRDL +N+L+ + +K+ADFGLAR I Y T+ Sbjct: 208 CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN-NIDYYKKTTNGR 266 Query: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA---LG 221 + + + +PE L Y+ D+WS G + E+ T + +++LF++ + + Sbjct: 267 LPVKWMAPEALFDRV-YTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMD 325 Query: 222 TPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLD 257 P N ++D + P +P + V++LD Sbjct: 326 KPANCTNELYMMMRDCWHAVPSQRP-TFKQLVEDLD 360 >3A8W-A nrPDB Length = 345 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 76/308 (24%), Positives = 142/308 (46%), Gaps = 31/308 (10%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE--SEEEGVPSTAIREISLLKEL 58 ++D+ + IG G+Y V R K T ++ AMK ++ E +++E + + + Sbjct: 8 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 67 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 HP +V L +SRL+ + E+++ DL ++ + + + Y +I + Sbjct: 68 NHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQR---QRKLPEEHARFYSAEISLALN 124 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 + H R +++RDLK N+L+D +G IKL D+G+ + P + T Y +PE+L G Sbjct: 125 YLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRG 184 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFH--GDSEI------DQLFRIF--RALGTPNNEV 227 Y VD W++G + E+ + F G S+ D LF++ + + P + Sbjct: 185 ED-YGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLS 243 Query: 228 WPEVESLQDYKNTFPKWKPGS--------LASH--VKNLDENGLDLLSKMLIYDPAK-RI 276 L+ + N PK + G + H +N+D D++ + + P K I Sbjct: 244 VKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVD---WDMMEQKQVVPPFKPNI 300 Query: 277 SGKMALNH 284 SG+ L++ Sbjct: 301 SGEFGLDN 308 >5H2U-A nrPDB Length = 267 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 59/223 (26%), Positives = 114/223 (51%), Gaps = 19/223 (8%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR-EISLLKELRH 60 E++T K+G G +G V++G K QV I++ S + + ++ EI +K+LRH Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWKDRVQVA----IKVISRDNLLHQQMLQSEIQAMKKLRH 61 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLS----MDLKKYLDS--IPPGQYMDSSLVKSYLYQILQ 114 +I++L V+ +Y+I E ++ ++L + D +P + +D + +Q+ + Sbjct: 62 KHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIA------WQVAE 115 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 G+ + S+ +HRDL +N+L+ + K+ DFGLAR + + + + +PE Sbjct: 116 GMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEA 175 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPL-FHGDSEIDQLFRI 216 L YST D+WS G + E+ ++ + + G S + R+ Sbjct: 176 -LSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRV 217 >2XYN-A nrPDB Length = 292 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 57/200 (28%), Positives = 101/200 (50%), Gaps = 9/200 (4%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D T K+G G YG VY G K VA+K ++ ++ E ++E +++KE++HPN Sbjct: 33 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME---VEEFLKEAAVMKEIKHPN 89 Query: 63 IVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLY-QILQGIVFCH 120 +V L V + Y++ E++ +L YL + +++V Y+ QI + + Sbjct: 90 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEV--TAVVLLYMATQISSAMEYLE 147 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEVVTLWYRSPEVLLGSA 179 + +HRDL +N L+ + +K+ADFGL+R G + + + +PE L Sbjct: 148 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES-LAYN 206 Query: 180 RYSTPVDIWSIGTIFAELAT 199 +S D+W+ G + E+AT Sbjct: 207 TFSIKSDVWAFGVLLWEIAT 226 >3DTC-A nrPDB Length = 271 Score = 82.0 bits (201), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 71/255 (27%), Positives = 119/255 (46%), Gaps = 24/255 (9%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE--GVPSTAIREISLLKELRHPNIVS 65 E IG G +G VY R G VA+K R + +E+ +E L L+HPNI++ Sbjct: 13 EIIGIGGFGKVY--RAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIA 70 Query: 66 LQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR-- 123 L+ V +++ L L+ EF L+ + G+ + ++ ++ QI +G+ + H Sbjct: 71 LRGVCLKEPNLCLVMEFAR---GGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIV 127 Query: 124 -VLHRDLKPQNLLIDDK--------GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 ++HRDLK N+LI K +K+ DFGLAR + ++ + +PEV Sbjct: 128 PIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYA--WMAPEV 185 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR---ALGTPNNEVWPEV 231 + S +S D+WS G + EL T + F G + + + AL P+ P Sbjct: 186 IRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFA 244 Query: 232 ESLQDYKNTFPKWKP 246 + ++D N P +P Sbjct: 245 KLMEDCWNPDPHSRP 259 >3DB8-A nrPDB Length = 317 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 65/226 (28%), Positives = 104/226 (46%), Gaps = 22/226 (9%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQV----VAMKKIRLESEEEGVPSTAIREISLLK 56 M+ Y + +G+G + Y+ T +V V K + L+ ++ ST EI++ K Sbjct: 41 MKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMST---EIAIHK 97 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLS----MDLKKYLDSI--PPGQYMDSSLVKSYLY 110 L +P++V D +Y++ E ++L K ++ P +Y ++ Sbjct: 98 SLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARY--------FMR 149 Query: 111 QILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYR 170 Q +QG+ + H+ RV+HRDLK NL ++D +K+ DFGLA T Y Sbjct: 150 QTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYI 209 Query: 171 SPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRI 216 +PEVL +S VDIWS+G I L KP F + RI Sbjct: 210 APEVLCKKG-HSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRI 254 >6CTH-A nrPDB Length = 309 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 63/208 (30%), Positives = 109/208 (52%), Gaps = 18/208 (8%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 ++ K+GEG +G VY+G + + +A+KK+ S++ G+ A E+ ++ LRH N Sbjct: 16 NFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQ-GIKEYA-SEVKIISRLRHKN 73 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDS-IPPGQYMDSSLVKSYLYQIL-QGIVFCH 120 +V L + L L++EF++ LDS I G+ + + V+ + + L +++ H Sbjct: 74 LVKLIGWCHERGELMLVYEFMA---NGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLH 130 Query: 121 SRR---VLHRDLKPQNLLIDDKGTIKLADFGLAR----AFGIPIRVYTHEVVTLWYRSPE 173 VLHRD+K N+++D KL DFGLAR A G+ + T+ Y +PE Sbjct: 131 EEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAG---TVGYMAPE 187 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKK 201 L S + S D++S G + E+A+ + Sbjct: 188 C-LSSGKASKESDVYSFGVVALEIASGR 214 >1FOT-A nrPDB Length = 318 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 68/297 (22%), Positives = 137/297 (46%), Gaps = 43/297 (14%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE--SEEEGVPSTAIREISLLKEL 58 ++D+ + +G G++G V+ R + G+ AMK ++ E + V T + +L + Sbjct: 5 LQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERL-MLSIV 63 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 HP I+ + ++++I +++ + + + Q + + K Y ++ + + Sbjct: 64 THPFIIRMWGTFQDAQQIFMIMDYI--EGGELFSLLRKSQRFPNPVAKFYAAEVCLALEY 121 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 HS+ +++RDLKP+N+L+D G IK+ DFG A+ +P YT T Y +PEV + + Sbjct: 122 LHSKDIIYRDLKPENILLDKNGHIKITDFGFAKY--VPDVTYTL-CGTPDYIAPEV-VST 177 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y+ +D WS G + E+ F+ + + +I A + Sbjct: 178 KPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNA------------------E 219 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG-----KMALNHPYFNDL 290 FP + +E+ DLLS+++ D ++R+ + NHP+F ++ Sbjct: 220 LRFPPF-----------FNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEV 265 >4XCU-A nrPDB Length = 300 Score = 81.6 bits (200), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 61/225 (27%), Positives = 117/225 (52%), Gaps = 19/225 (8%) Query: 10 IGEGTYGVVYKGR-------HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHP 61 +GEG +G V + VA+K ++ + ++ + + + E+ ++K + RH Sbjct: 25 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDL-ADLVSEMEVMKLIGRHK 83 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSI-PPGQY---MDSSLVKSYLYQILQGI 116 NI++L V Q+ LY+I E + +L+++L + PPG + ++ S YQ+ +G+ Sbjct: 84 NIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAYQVARGM 143 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY---THEVVTLWYRSPE 173 + SR+ +HRDL +N+L+ + +K+ADFGLAR I Y ++ + + + +PE Sbjct: 144 QYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHH-IDYYKKTSNGRLPVKWMAPE 202 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 218 L Y+ D+WS G + E+ T + +++LF + R Sbjct: 203 ALFDRV-YTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLR 246 >3QGY-A nrPDB Length = 286 Score = 81.6 bits (200), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 60/202 (29%), Positives = 105/202 (51%), Gaps = 13/202 (6%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 + T +++IG G +G+V+ G + VA+K I+ S E I E ++ +L HP Sbjct: 28 ELTFVQEIGSGQFGLVHLG-YWLNKDKVAIKTIKEGSMSE---DDFIEEAEVMMKLSHPK 83 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +V L V ++ + + L+FEF+ L YL + G + +L+ L + +G+ + Sbjct: 84 LVQLYGVCLEQAPICLVFEFMEHGCLSDYLRT-QRGLFAAETLLGMCL-DVCEGMAYLEE 141 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLW---YRSPEVLLGS 178 V+HRDL +N L+ + IK++DFG+ R + YT T + + SPEV Sbjct: 142 ACVIHRDLAARNCLVGENQVIKVSDFGMTRF--VLDDQYTSSTGTKFPVKWASPEV-FSF 198 Query: 179 ARYSTPVDIWSIGTIFAELATK 200 +RYS+ D+WS G + E+ ++ Sbjct: 199 SRYSSKSDVWSFGVLMWEVFSE 220 >6GVJ-A nrPDB Length = 429 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 83/309 (26%), Positives = 140/309 (45%), Gaps = 47/309 (15%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN- 62 Y+ +++IG G V++ ++ Q+ A+K + LE + + EI+ L +L+ + Sbjct: 146 YSILKQIGSGGSSKVFQVLNEKK-QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 63 -IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 I+ L D + D +Y++ E ++DL +L + +D KSY +L+ + H Sbjct: 205 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKK---KKSIDPWERKSYWKNMLEAVHTIHQ 261 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--VYTHEVVTLWYRSPEVL--LG 177 ++H DLKP N LI D G +KL DFG+A V +V T+ Y PE + + Sbjct: 262 HGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMS 320 Query: 178 SARYS--------TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 S+R + D+WS+G I + K F I+Q+ ++ A+ PN+E+ Sbjct: 321 SSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKL-HAIIDPNHEI-- 375 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGL-DLLSKMLIYDPAKRISGKMALNHPYFN 288 FP ++ E L D+L L DP +RIS L HPY Sbjct: 376 ----------EFP------------DIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 413 Query: 289 DLDNQIKKM 297 + + +M Sbjct: 414 IQTHPVNQM 422 >5EG3-A nrPDB Length = 334 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 68/275 (24%), Positives = 132/275 (48%), Gaps = 30/275 (10%) Query: 10 IGEGTYGVVYKGR-------HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHP 61 +GEG +G V VA+K ++ ++ E+ + S + E+ ++K + +H Sbjct: 43 LGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL-SDLVSEMEMMKMIGKHK 101 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSI-PPGQYMDSSLVK------------S 107 NI++L QD LY+I + S +L++YL + PPG + + + S Sbjct: 102 NIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQMTFKDLVS 161 Query: 108 YLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP--IRVYTHEVV 165 YQ+ +G+ + S++ +HRDL +N+L+ + +K+ADFGLAR + T+ + Sbjct: 162 CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFFKETTNGRL 221 Query: 166 TLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA---LGT 222 + + +PE L Y+ D+WS G + E+ T + +++LF++ + + Sbjct: 222 PVKWMAPEALFDRV-YTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDK 280 Query: 223 PNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLD 257 P N ++D + P +P + V++LD Sbjct: 281 PANCTNELYMMMRDCWHAVPSQRP-TFKQLVEDLD 314 >3HMP-A nrPDB Length = 342 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 83/300 (27%), Positives = 134/300 (44%), Gaps = 51/300 (17%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN- 62 Y+ +++IG G V++ ++ Q+ A+K + LE + + EI+ L +L+ + Sbjct: 58 YSILKQIGSGGSSKVFQVLNEKK-QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 63 -IVSLQDVLMQDSRLYLIFEFLSMDLKKYLD---SIPPGQYMDSSLVKSYLYQILQGIVF 118 I+ L D + D +Y++ E ++DL +L SI P + KSY +L+ + Sbjct: 117 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWER------KSYWKNMLEAVHT 170 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVL- 175 H ++H DLKP N LI D G +KL DFG+A V +V T+ Y PE + Sbjct: 171 IHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 229 Query: 176 -LGSARYS--------TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNE 226 + S+R + D+WS+G I + K F I+Q+ ++ A+ PN+E Sbjct: 230 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKL-HAIIDPNHE 286 Query: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 + FP L D+L L DP +RIS L HPY Sbjct: 287 I------------EFPDIPEKDLQ-----------DVLKCCLKRDPKQRISIPELLAHPY 323 >4B6L-A nrPDB Length = 281 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 63/219 (28%), Positives = 100/219 (45%), Gaps = 11/219 (5%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI---RLESEEEGVPSTAIREISLLKELRH 60 Y K +G+G + Y+ TG A+K I R+ + + EI L ++L+H Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQR--EKILNEIELHRDLQH 68 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQY-MDSSLVKSYLYQILQGIVFC 119 +IV +Y+ E S +K L I ++ + V+ YL QIL G+ + Sbjct: 69 RHIVRFSHHFEDADNIYIFLELCS---RKSLAHIWKARHTLLEPEVRYYLRQILSGLKYL 125 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 H R +LHRDLK N I + +K+ DFGLA P + T Y +PEVLL Sbjct: 126 HQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQG 185 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 218 + D+WS+G + L P F +++ + +R + Sbjct: 186 -HGPEADVWSLGCVMYTLLCGSPPFE-TADLKETYRCIK 222 >5AP3-A nrPDB Length = 313 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 83/300 (27%), Positives = 134/300 (44%), Gaps = 51/300 (17%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN- 62 Y+ +++IG G V++ ++ Q+ A+K + LE + + EI+ L +L+ + Sbjct: 30 YSILKQIGSGGSSKVFQVLNEKK-QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 63 -IVSLQDVLMQDSRLYLIFEFLSMDLKKYLD---SIPPGQYMDSSLVKSYLYQILQGIVF 118 I+ L D + D +Y++ E ++DL +L SI P + KSY +L+ + Sbjct: 89 KIIRLYDYEITDQYIYMVMECGNIDLNGWLKKKKSIDPWER------KSYWKNMLEAVHT 142 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVL- 175 H ++H DLKP N LI D G +KL DFG+A V +V T+ Y PE + Sbjct: 143 IHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIK 201 Query: 176 -LGSARYS--------TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNE 226 + S+R + D+WS+G I + K F I+Q+ ++ A+ PN+E Sbjct: 202 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKL-HAIIDPNHE 258 Query: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 + FP L D+L L DP +RIS L HPY Sbjct: 259 I------------EFPDIPEKDLQ-----------DVLKCCLKRDPKQRISIPELLAHPY 295 >2I0E-A nrPDB Length = 353 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 57/221 (25%), Positives = 113/221 (51%), Gaps = 14/221 (6%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES--EEEGVPSTAIREISLLKEL 58 + D+ + +G+G++G V K T ++ A+K ++ + +++ V T + + L Sbjct: 19 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 78 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 + P + L RLY + E+++ DL ++ + G++ + V Y +I G+ Sbjct: 79 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV--GRFKEPHAV-FYAAEIAIGLF 135 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF---GIPIRVYTHEVVTLWYRSPEV 174 F S+ +++RDLK N+++D +G IK+ADFG+ + G+ + + T Y +PE+ Sbjct: 136 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYIAPEI 192 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFR 215 + Y VD W+ G + E+ + F G+ E D+LF+ Sbjct: 193 -IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE-DELFQ 231 >5B2L-A nrPDB Length = 324 Score = 80.5 bits (197), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 97/209 (46%), Gaps = 18/209 (8%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 + D + ++G GT G V+K R + TG V+A+K++R +E + +LK Sbjct: 16 INDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDC 75 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMD---LKKYLDSIPPGQY---MDSSLVKSYLYQILQ 114 P IV + ++ +++ E + LKK + P + M ++VK+ Y Sbjct: 76 PYIVQCFGTFITNTDVFIAMELMGTSAEKLKKRMQGPIPERILGKMTVAIVKALYY---- 131 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 V+HRD+KP N+L+D++G IKL DFG++ + + T Y +PE Sbjct: 132 ---LKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRL-VDSKAKTRSAGCAAYMAPER 187 Query: 175 L----LGSARYSTPVDIWSIGTIFAELAT 199 + Y D+WS+G ELAT Sbjct: 188 IDPPDPTKPDYDIRADVWSLGISLVELAT 216 >2H8H-A nrPDB Length = 535 Score = 80.5 bits (197), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 75/268 (27%), Positives = 125/268 (46%), Gaps = 38/268 (14%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 K+G+G +G V+ G T +V A+K ++ + P ++E ++K+LRH +V L Sbjct: 274 KLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 329 Query: 69 VLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHR 127 V+ ++ +Y++ E++S L +L G+Y+ + QI G+ + +HR Sbjct: 330 VVSEEP-IYIVTEYMSKGSLLDFLKG-ETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 387 Query: 128 DLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV---VTLWYRSPEVLLGSARYSTP 184 DL+ N+L+ + K+ADFGLAR I YT + + +PE L R++ Sbjct: 388 DLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAAL-YGRFTIK 444 Query: 185 VDIWSIGTIFAELATKK----PLFHGDSEIDQLFRIFRALGTPN---------NEVW--- 228 D+WS G + EL TK P +DQ+ R +R P + W Sbjct: 445 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE 504 Query: 229 ----PEVESLQ----DY-KNTFPKWKPG 247 P E LQ DY +T P+++PG Sbjct: 505 PEERPTFEYLQAFLEDYFTSTEPQYQPG 532 >6BDL-A nrPDB Length = 347 Score = 80.5 bits (197), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 62/223 (27%), Positives = 105/223 (47%), Gaps = 8/223 (3%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTT-GQVVAMKKIRLESEEEGVPSTAIREISLLKELR 59 + D+ I+ +G G +G V + K+ + AMK ++ + IR + + Sbjct: 33 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 92 Query: 60 HPN-IVSLQDVLMQDSRLYLIFE-FLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 H + IV L LY++ E L +L L G + DS+ + Y +++ Sbjct: 93 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRD--RGSFEDST-TRFYTACVVEAFA 149 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 + HS+ +++RDLKP+NL++D +G KL DFG A+ G + +T T Y +PE++L Sbjct: 150 YLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTF-CGTPEYVAPEIILN 208 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRAL 220 + D WS+G + EL T P F G + I R + Sbjct: 209 KG-HDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGI 250 >2PL0-A nrPDB Length = 289 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 58/197 (29%), Positives = 103/197 (52%), Gaps = 13/197 (6%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 +E++G G +G V+ G + +V A+K ++ S P + E +L+K+L+H +V L Sbjct: 28 VERLGAGQFGEVWMGYYNGHTKV-AVKSLKQGSMS---PDAFLAEANLMKQLQHQRLVRL 83 Query: 67 QDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 125 V+ Q+ +Y+I E++ + L +L + P G + + + QI +G+ F R + Sbjct: 84 YAVVTQEP-IYIITEYMENGSLVDFLKT-PSGIKLTINKLLDMAAQIAEGMAFIEERNYI 141 Query: 126 HRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHE---VVTLWYRSPEVLLGSARYS 182 HRDL+ N+L+ D + K+ADFGLAR I YT + + +PE + ++ Sbjct: 142 HRDLRAANILVSDTLSCKIADFGLARL--IEDNEYTAREGAKFPIKWTAPEA-INYGTFT 198 Query: 183 TPVDIWSIGTIFAELAT 199 D+WS G + E+ T Sbjct: 199 IKSDVWSFGILLTEIVT 215 >3PFQ-A nrPDB Length = 674 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 57/221 (25%), Positives = 113/221 (51%), Gaps = 14/221 (6%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES--EEEGVPSTAIREISLLKEL 58 + D+ + +G+G++G V K T ++ A+K ++ + +++ V T + + L Sbjct: 340 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 399 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 + P + L RLY + E+++ DL ++ + G++ + V Y +I G+ Sbjct: 400 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV--GRFKEPHAV-FYAAEIAIGLF 456 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF---GIPIRVYTHEVVTLWYRSPEV 174 F S+ +++RDLK N+++D +G IK+ADFG+ + G+ + + T Y +PE+ Sbjct: 457 FLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCG---TPDYIAPEI 513 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFR 215 + Y VD W+ G + E+ + F G+ E D+LF+ Sbjct: 514 -IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDE-DELFQ 552 >6F3F-A nrPDB Length = 455 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 75/269 (27%), Positives = 125/269 (46%), Gaps = 40/269 (14%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 K+G+G +G V+ G T +V A+K ++ + P ++E ++K+LRH +V L Sbjct: 194 KLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 249 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSI--PPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 V+ ++ +Y++ E+ M+ LD + G+Y+ + QI G+ + +H Sbjct: 250 VVSEEP-IYIVTEY--MNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVH 306 Query: 127 RDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV---VTLWYRSPEVLLGSARYST 183 RDL+ N+L+ + K+ADFGLAR I YT + + +PE L R++ Sbjct: 307 RDLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAAL-YGRFTI 363 Query: 184 PVDIWSIGTIFAELATKK----PLFHGDSEIDQLFRIFRALGTPN---------NEVW-- 228 D+WS G + EL TK P +DQ+ R +R P + W Sbjct: 364 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRK 423 Query: 229 -----PEVESLQ----DY-KNTFPKWKPG 247 P E LQ DY +T P+++PG Sbjct: 424 EPEERPTFEYLQAFLEDYFTSTEPQYQPG 452 >6FER-A nrPDB Length = 309 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 64/220 (29%), Positives = 108/220 (49%), Gaps = 32/220 (14%) Query: 8 EKIGEGTYGVVY----KGRHKTTGQ------------VVAMKKIRLESEEEGVPSTAIRE 51 EK+GEG +G V+ +G K + +VA+K +R ++ + + ++E Sbjct: 15 EKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNA-RNDFLKE 73 Query: 52 ISLLKELRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLY 110 I ++ L+ PNI+ L V + D L +I E++ + DL ++L P SS V++ Y Sbjct: 74 IKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPN-SSSSDVRTVSY 132 Query: 111 --------QILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVY 160 QI G+ + S +HRDL +N L+ TIK+ADFG++R G R+ Sbjct: 133 TNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQ 192 Query: 161 THEVVTL-WYRSPEVLLGSARYSTPVDIWSIGTIFAELAT 199 V+ + W +LLG +++T D+W+ G E T Sbjct: 193 GRAVLPIRWMSWESILLG--KFTTASDVWAFGVTLWETFT 230 >3SXS-A nrPDB Length = 268 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 60/201 (29%), Positives = 105/201 (52%), Gaps = 15/201 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQV-VAMKKIRLESEEEGVPSTAIREISLLKELRH 60 E+ T ++++G G +GVV G+ K GQ VA+K I+ S E +E + +L H Sbjct: 8 EEITLLKELGSGQFGVVKLGKWK--GQYDVAVKMIKEGSMSE---DEFFQEAQTMMKLSH 62 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 P +V V ++ +Y++ E++S L YL S G+ ++ S + Y + +G+ F Sbjct: 63 PKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRS--HGKGLEPSQLLEMCYDVCEGMAFL 120 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLW---YRSPEVLL 176 S + +HRDL +N L+D +K++DFG+ R + Y V T + + +PEV Sbjct: 121 ESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRY--VLDDQYVSSVGTKFPVKWSAPEV-F 177 Query: 177 GSARYSTPVDIWSIGTIFAEL 197 +YS+ D+W+ G + E+ Sbjct: 178 HYFKYSSKSDVWAFGILMWEV 198 >5UUU-A nrPDB Length = 547 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 106/207 (51%), Gaps = 20/207 (9%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMK-----KIRLESEEEGVPSTAIRE---I 52 M D++ IG G +G VY R TG++ AMK +I+++ E + A+ E + Sbjct: 197 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE----TLALNERIML 252 Query: 53 SLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQ 111 SL+ P IV + +L I + ++ DL +L G + ++ + + Y + Sbjct: 253 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ--HGVFSEADM-RFYAAE 309 Query: 112 ILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYR 170 I+ G+ H+R V++RDLKP N+L+D+ G ++++D GLA F + H V T Y Sbjct: 310 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS---KKKPHASVGTHGYM 366 Query: 171 SPEVLLGSARYSTPVDIWSIGTIFAEL 197 +PEVL Y + D +S+G + +L Sbjct: 367 APEVLQKGVAYDSSADWFSLGCMLFKL 393 >5SYS-A nrPDB Length = 286 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 72/268 (26%), Positives = 123/268 (45%), Gaps = 38/268 (14%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 K+G+G +G + G T +V A+K ++ + P ++E ++K+LRH +V L Sbjct: 25 KLGQGCFGECWMGTWNGTTRV-AIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 80 Query: 69 VLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHR 127 V+ ++ +Y++ E++S L +L G+Y+ + QI G+ + +HR Sbjct: 81 VVSEEP-IYIVTEYMSKGSLLDFLKG-EMGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 138 Query: 128 DLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV---VTLWYRSPEVLLGSARYSTP 184 DL+ N+L+ + K+ADFGLAR I YT + + +PE L R++ Sbjct: 139 DLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAAL-YGRFTIK 195 Query: 185 VDIWSIGTIFAELATKK----PLFHGDSEIDQLFRIFRALGTPN---------NEVW--- 228 D+WS G + EL TK P +DQ+ R +R P + W Sbjct: 196 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKD 255 Query: 229 ----PEVESLQD-----YKNTFPKWKPG 247 P E LQ + +T P+++PG Sbjct: 256 PEERPTFEYLQAFLEDYFTSTEPQYQPG 283 >2X7G-A nrPDB Length = 389 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 100/366 (27%), Positives = 148/366 (40%), Gaps = 91/366 (24%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH--- 60 Y I K+G G + V+ + VAMK ++ + TA+ EI LLK +R Sbjct: 33 YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK---SAQHYTETALDEIKLLKCVRESDP 89 Query: 61 --PN---IVSLQDVL----MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQ 111 PN +V L D M + ++FE L L K++ Q + VKS + Q Sbjct: 90 SDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIK-SNYQGLPVRCVKSIIRQ 148 Query: 112 ILQGIVFCHSR-RVLHRDLKPQNLLI---------------------------------- 136 +LQG+ + HS+ +++H D+KP+N+L+ Sbjct: 149 VLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAP 208 Query: 137 -------------DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYST 183 DK +K+AD G A + +T ++ T YRS EVL+G A YST Sbjct: 209 AADLLVNPLDPRNADKIRVKIADLGNACWVH---KHFTEDIQTRQYRSIEVLIG-AGYST 264 Query: 184 PVDIWSIGTIFAELATKKPLFHGDS------EIDQLFRIFRALGTPNNEVWPEVESLQDY 237 P DIWS + ELAT LF S + D + I LG+ + +++ Sbjct: 265 PADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREF 324 Query: 238 KNT------FPKWKPGSLASHVKNLDENGL---------DLLSKMLIYDPAKRISGKMAL 282 N K KP SL + +++ G D L ML P KR S L Sbjct: 325 FNRRGELRHITKLKPWSLFDVL--VEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECL 382 Query: 283 NHPYFN 288 HP+ N Sbjct: 383 RHPWLN 388 >5TOS-A nrPDB Length = 395 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 69/216 (31%), Positives = 105/216 (48%), Gaps = 27/216 (12%) Query: 10 IGEGTYGVVYKG---------RHKTTGQVVAMKKIRLESEEEGVPSTA--IREISLLKEL 58 IGEG +G V+KG TG V+A+KK+ +EG + EI+ L +L Sbjct: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL----NQEGFQGHREWLTEINYLGQL 128 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDS---SLVKSYLYQILQ 114 HPN+V L ++D L++EF+ L+ +L G Y L + + Sbjct: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHL--FRRGAYFKPLPWFLRVNVALDAAK 186 Query: 115 GIVFCHSR--RVLHRDLKPQNLLIDDKGTIKLADFGLAR--AFGIPIRVYTHEVVTLWYR 170 G+ F HS +V++RD+K N+L+D KL+DFGLAR G V T + T Y Sbjct: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYA 246 Query: 171 SPEVLLGSARYSTPVDIWSIGTIFAE-LATKKPLFH 205 +PE + S + D++S G + E L+ K+ L H Sbjct: 247 APE-YMSSGHLNARSDVYSFGVLLLEILSGKRALDH 281 >4AW2-A nrPDB Length = 437 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 79/305 (25%), Positives = 130/305 (42%), Gaps = 47/305 (15%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRH 60 ED+ ++ IG G +G V + K +V AMK + + E + + E +L Sbjct: 74 EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDS 133 Query: 61 PNIVSLQDVLMQDSRLYLIFEF-----LSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 I +L D+ LYL+ ++ L L K+ D +P + + YL +++ Sbjct: 134 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLP------EEMARFYLAEMVIA 187 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEV 174 I H +HRD+KP N+L+D G I+LADFG V + V T Y SPE+ Sbjct: 188 IDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEI 247 Query: 175 LL----GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPE 230 L G RY D WS+G E+ + F+ +S ++ +I Sbjct: 248 LQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIM------------- 294 Query: 231 VESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN----HPY 286 ++K F + V ++ EN DL+ + LI R+ G+ + HP+ Sbjct: 295 -----NHKERF------QFPTQVTDVSENAKDLIRR-LICSREHRL-GQNGIEDFKKHPF 341 Query: 287 FNDLD 291 F+ +D Sbjct: 342 FSGID 346 >4HVI-A nrPDB Length = 314 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 64/204 (31%), Positives = 104/204 (50%), Gaps = 17/204 (8%) Query: 7 IEKIGEGTYGVVYKGRHK----TTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 I ++G+G +G V R+ TG +VA+K+++ ++ REI +LK L Sbjct: 15 ISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQ--RDFQREIQILKALHSDF 72 Query: 63 IVSLQDVLMQDSR--LYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 IV + V R L L+ E+L S L+ +L +D+S + Y QI +G+ + Sbjct: 73 IVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRH--RARLDASRLLLYSSQICKGMEYL 130 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT----HEVVTLWYRSPEVL 175 SRR +HRDL +N+L++ + +K+ADFGLA+ + Y + WY +PE L Sbjct: 131 GSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWY-APESL 189 Query: 176 LGSARYSTPVDIWSIGTIFAELAT 199 + +S D+WS G + EL T Sbjct: 190 SDNI-FSRQSDVWSFGVVLYELFT 212 >2ZMD-A nrPDB Length = 390 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 83/301 (27%), Positives = 136/301 (45%), Gaps = 53/301 (17%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN- 62 Y+ +++IG G V++ ++ Q+ A+K + LE + + EI+ L +L+ + Sbjct: 58 YSILKQIGSGGSSKVFQVLNEKK-QIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 63 -IVSLQDVLMQDSRLYLIFEFLSMDLKKYLD---SIPPGQYMDSSLVKSYLYQILQGIVF 118 I+ L D + D +Y++ E ++DL +L SI P + KSY +L+ + Sbjct: 117 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWER------KSYWKNMLEAVHT 170 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVL- 175 H ++H DLKP N LI D G +KL DFG+A V +V + Y PE + Sbjct: 171 IHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIK 229 Query: 176 -LGSARYS--------TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNE 226 + S+R + D+WS+G I + K F I+Q+ ++ A+ PN+E Sbjct: 230 DMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKL-HAIIDPNHE 286 Query: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGL-DLLSKMLIYDPAKRISGKMALNHP 285 + FP ++ E L D+L L DP +RIS L HP Sbjct: 287 I------------EFP------------DIPEKDLQDVLKCCLKRDPKQRISIPELLAHP 322 Query: 286 Y 286 Y Sbjct: 323 Y 323 >3PLS-A nrPDB Length = 298 Score = 78.6 bits (192), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 56/200 (28%), Positives = 109/200 (54%), Gaps = 13/200 (6%) Query: 10 IGEGTYGVVYKGRHKTTGQ---VVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 IG+G +GVVY G + Q A+K + +E + V +RE L++ L HPN+++L Sbjct: 29 IGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQV-EAFLREGLLMRGLNHPNVLAL 87 Query: 67 QDVLMQDSRL-YLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 124 +++ L +++ ++ DL +++ S P + + S+ Q+ +G+ + ++ Sbjct: 88 IGIMLPPEGLPHVLLPYMCHGDLLQFIRS--PQRNPTVKDLISFGLQVARGMEYLAEQKF 145 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVLLGSAR 180 +HRDL +N ++D+ T+K+ADFGLAR ++ + H + + + + E L + R Sbjct: 146 VHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALES-LQTYR 204 Query: 181 YSTPVDIWSIGTIFAELATK 200 ++T D+WS G + EL T+ Sbjct: 205 FTTKSDVWSFGVLLWELLTR 224 >3PVW-A nrPDB Length = 695 Score = 78.6 bits (192), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 62/207 (29%), Positives = 106/207 (51%), Gaps = 20/207 (9%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMK-----KIRLESEEEGVPSTAIRE---I 52 M D++ IG G +G VY R TG++ AMK +I+++ E + A+ E + Sbjct: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE----TLALNERIML 243 Query: 53 SLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQ 111 SL+ P IV + +L I + ++ DL +L G + ++ + + Y + Sbjct: 244 SLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ--HGVFSEADM-RFYAAE 300 Query: 112 ILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYR 170 I+ G+ H+R V++RDLKP N+L+D+ G ++++D GLA F + H V T Y Sbjct: 301 IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS---KKKPHASVGTHGYM 357 Query: 171 SPEVLLGSARYSTPVDIWSIGTIFAEL 197 +PEVL Y + D +S+G + +L Sbjct: 358 APEVLQKGVAYDSSADWFSLGCMLFKL 384 >6DBM-A nrPDB Length = 318 Score = 78.2 bits (191), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 63/234 (26%), Positives = 114/234 (48%), Gaps = 25/234 (10%) Query: 6 KIEKIGEGTYGVV----YKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 KI +GEG +G V Y + TG++VA+K ++ ++ + S +EI +L+ L H Sbjct: 35 KIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHR-SGWKQEIDILRTLYHE 93 Query: 62 NIVSLQDVL--MQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 +I+ + + L L+ E++ + L+ YL P + + + + QI +G+ + Sbjct: 94 HIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYL----PRHSIGLAQLLLFAQQICEGMAY 149 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP-----IRVYTHEVVTLWYRSPE 173 HS+ +HRDL +N+L+D+ +K+ DFGLA+A +P RV +++ +PE Sbjct: 150 LHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKA--VPEGHEYYRVREDGDSPVFWYAPE 207 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEV 227 L ++ D+WS G EL T H DS + +G ++ Sbjct: 208 C-LKEYKFYYASDVWSFGVTLYELLT-----HCDSSQSPPTKFLELIGIAQGQM 255 >3HDN-A nrPDB Length = 373 Score = 78.2 bits (191), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 100/209 (47%), Gaps = 11/209 (5%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKT-----TGQVVAMKKIRLESEEEGVPSTAIREISLLKE 57 D+ ++ IG+G++G V RHK +V+ K I + EE+ + S R + LLK Sbjct: 39 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE--RNV-LLKN 95 Query: 58 LRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 ++HP +V L +LY + ++++ Y + + + Y +I + Sbjct: 96 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFY--HLQRERCFLEPRARFYAAEIASALG 153 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 + HS +++RDLKP+N+L+D +G I L DFGL + + T Y +PEV L Sbjct: 154 YLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEV-LH 212 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHG 206 Y VD W +G + E+ P F+ Sbjct: 213 KQPYDRTVDWWCLGAVLYEMLYGLPPFYS 241 >2RIO-A nrPDB Length = 434 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 85/311 (27%), Positives = 140/311 (45%), Gaps = 62/311 (19%) Query: 8 EKI-GEGTYG-VVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR-HPNIV 64 EKI G G+ G VV++G + G+ VA+K++ ++ A+ EI LL E HPN++ Sbjct: 20 EKILGYGSSGTVVFQGSFQ--GRPVAVKRMLID-----FCDIALMEIKLLTESDDHPNVI 72 Query: 65 SLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSY-----LYQILQGIVFC 119 D LY+ E +++L+ ++S + L K Y L QI G+ Sbjct: 73 RYYCSETTDRFLYIALELCNLNLQDLVESKNVSDE-NLKLQKEYNPISLLRQIASGVAHL 131 Query: 120 HSRRVLHRDLKPQNLLID-------DKGT------IKLADFGLARAFGIPIRVYTHEVV- 165 HS +++HRDLKPQN+L+ D+ T I ++DFGL + + + Sbjct: 132 HSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNN 191 Query: 166 ---TLWYRSPEVLLGSA------RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRI 216 T +R+PE+L S R + +DI+S+G +F + +K GD Sbjct: 192 PSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKY------- 244 Query: 217 FRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI 276 + + + + SL + K H ++L DL+S+M+ +DP KR Sbjct: 245 -----SRESNIIRGIFSLDEMK-----------CLHDRSLIAEATDLISQMIDHDPLKRP 288 Query: 277 SGKMALNHPYF 287 + L HP F Sbjct: 289 TAMKVLRHPLF 299 >4TNB-A nrPDB Length = 590 Score = 77.4 bits (189), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 61/205 (29%), Positives = 106/205 (51%), Gaps = 11/205 (5%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPSTAIREISLLKELRHPNIVSLQD 68 +G+G +G V + + TG++ A K++ + ++ S A+ E +L+++ +V+L Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAY 251 Query: 69 VLMQDSRLYLIFEFLSM-DLKKYLDSI-PPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 L L+ ++ DLK ++ ++ PG + +L Y +IL G+ H ++ Sbjct: 252 AYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALF--YAAEILCGLEDLHHENTVY 309 Query: 127 RDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVLLGSARYSTP 184 RDLKP+N+L+DD G I+++D GLA G IR V T+ Y +PEV L + RY Sbjct: 310 RDLKPENILLDDYGHIRISDLGLAVKIPEGDLIR---GRVGTVGYMAPEV-LNNQRYGLS 365 Query: 185 VDIWSIGTIFAELATKKPLFHGDSE 209 D W +G + E+ + F G E Sbjct: 366 PDYWGLGCLIYEMIEGQSPFRGRKE 390 >4AT3-A nrPDB Length = 299 Score = 77.4 bits (189), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 63/237 (26%), Positives = 116/237 (48%), Gaps = 26/237 (10%) Query: 9 KIGEGTYGVVYKGRHKTTGQ-----VVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 ++GEG +G V+ +VA+K ++ S+ RE LL L+H +I Sbjct: 20 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDN--ARKDFHREAELLTNLQHEHI 77 Query: 64 VSLQDVLMQDSRLYLIFEFLSM-DLKKYL-----DSI------PPGQYMDSSLVKSYLYQ 111 V V ++ L ++FE++ DL K+L D++ PP + S ++ Q Sbjct: 78 VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH-IAQQ 136 Query: 112 ILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP--IRVYTHEVVTLWY 169 I G+V+ S+ +HRDL +N L+ + +K+ DFG++R RV H ++ + + Sbjct: 137 IAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRW 196 Query: 170 RSPEVLLGSARYSTPVDIWSIGTIFAELAT--KKPLFH-GDSEIDQLFRIFRALGTP 223 PE ++ +++T D+WS+G + E+ T K+P + ++E+ + R L P Sbjct: 197 MPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRP 252 >1LUF-A nrPDB Length = 343 Score = 77.4 bits (189), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 59/228 (25%), Positives = 108/228 (47%), Gaps = 47/228 (20%) Query: 7 IEKIGEGTYGVVYKGRHK-----TTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + IGEG +G V++ R +VA+K ++ E+ + + + RE +L+ E +P Sbjct: 52 VRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASAD-MQADFQREAALMAEFDNP 110 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLY---------- 110 NIV L V + L+FE+++ DL ++L S+ P + SL S L Sbjct: 111 NIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSP--HTVCSLSHSDLSTRARVSSPGP 168 Query: 111 -------------QILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI 157 Q+ G+ + R+ +HRDL +N L+ + +K+ADFGL+R Sbjct: 169 PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSR------ 222 Query: 158 RVYT--------HEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL 197 +Y+ ++ + + + PE + + RY+T D+W+ G + E+ Sbjct: 223 NIYSADYYKADGNDAIPIRWMPPESIFYN-RYTTESDVWAYGVVLWEI 269 >5KCV-A nrPDB Length = 460 Score = 77.4 bits (189), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 77/299 (25%), Positives = 139/299 (46%), Gaps = 49/299 (16%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES--EEEGVPSTAIREISLLKEL 58 M ++ ++ +G+GT+G V + K TG+ AMK ++ E ++ V T + E +L+ Sbjct: 161 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT-LTENRVLQNS 219 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 RHP + +L+ RL + E+ + + + + + Y +I+ + + Sbjct: 220 RHPFLTALKYSFQTHDRLCFVMEYANGG--ELFFHLSRERVFSEDRARFYGAEIVSALDY 277 Query: 119 CHSRR-VLHRDLKPQNLLIDDKGTIKLADFGLARAF---GIPIRVYTHEVVTLWYRSPEV 174 HS + V++RDLK +NL++D G IK+ DFGL + G ++ + T Y +PEV Sbjct: 278 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPEYLAPEV 334 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 233 L + Y VD W +G + E+ + P ++ D E +LF + +E Sbjct: 335 LEDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHE--KLFELIL------------MEE 379 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG-----KMALNHPYF 287 ++ FP+ +L K+ LLS +L DP +R+ G K + H +F Sbjct: 380 IR-----FPR----TLGPEAKS-------LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 422 >4XI2-A nrPDB Length = 446 Score = 77.4 bits (189), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 59/201 (29%), Positives = 106/201 (52%), Gaps = 15/201 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQV-VAMKKIRLESEEEGVPSTAIREISLLKELRH 60 +D T ++++G G +GVV G+ + GQ VA+K IR S E I E ++ L H Sbjct: 187 KDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIREGSMSE---DEFIEEAKVMMNLSH 241 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 +V L V + +++I E+++ L YL + + + + + + + Sbjct: 242 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMR--HRFQTQQLLEMCKDVCEAMEYL 299 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLW---YRSPEVLL 176 S++ LHRDL +N L++D+G +K++DFGL+R + YT V + + + PEVL+ Sbjct: 300 ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRY--VLDDEYTSSVGSKFPVRWSPPEVLM 357 Query: 177 GSARYSTPVDIWSIGTIFAEL 197 S ++S+ DIW+ G + E+ Sbjct: 358 YS-KFSSKSDIWAFGVLMWEI 377 >4E20-A nrPDB Length = 290 Score = 77.0 bits (188), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 59/205 (28%), Positives = 101/205 (49%), Gaps = 18/205 (8%) Query: 6 KIEKIGEGTYGVV----YKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 KI +GEG +G V Y + TG++VA+K ++ E + S REI +L+ L H Sbjct: 12 KIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALK-EGCGPQLRSGWQREIEILRTLYHE 70 Query: 62 NIVSLQDVL--MQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 +IV + + + L+ E++ + L+ YL P + + + + QI +G+ + Sbjct: 71 HIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYL----PRHCVGLAQLLLFAQQICEGMAY 126 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT----HEVVTLWYRSPEV 174 H++ +HR L +N+L+D+ +K+ DFGLA+A Y + WY +PE Sbjct: 127 LHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-APEC 185 Query: 175 LLGSARYSTPVDIWSIGTIFAELAT 199 L ++ D+WS G EL T Sbjct: 186 -LKECKFYYASDVWSFGVTLYELLT 209 >3DLS-A nrPDB Length = 335 Score = 77.0 bits (188), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 98/211 (46%), Gaps = 12/211 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESE------EEGVPSTAIREISLL 55 + Y+ + +G G +G V+ K + V +K I+ E E+ EI++L Sbjct: 24 QKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAIL 83 Query: 56 KELRHPNIVSLQDVLMQDSRLYLIFE--FLSMDLKKYLDSIPPGQYMDSSLVKSYLYQIL 113 + H NI+ + D+ L+ E +DL ++D P +D L Q++ Sbjct: 84 SRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHP---RLDEPLASYIFRQLV 140 Query: 114 QGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 173 + + + ++HRD+K +N++I + TIKL DFG A YT T+ Y +PE Sbjct: 141 SAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTF-CGTIEYCAPE 199 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLF 204 VL+G+ +++WS+G L ++ F Sbjct: 200 VLMGNPYRGPELEMWSLGVTLYTLVFEENPF 230 >5O2B-A nrPDB Length = 285 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 76/290 (26%), Positives = 130/290 (44%), Gaps = 43/290 (14%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIV---- 64 ++G G + VYKG T VA +++ + E +LK L+HPNIV Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 82 Query: 65 SLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 S + +L + L+ E + S LK YL + M +++S+ QIL+G+ F H+R Sbjct: 83 SWESILKGKKCIVLVTELMTSGTLKTYLKRF---KVMKPKVLRSWCRQILKGLQFLHTRT 139 Query: 124 --VLHRDLKPQNLLIDD-KGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEVLLGSA 179 ++HRDLK N+ I G++K+ D GLA + V+ T + +PE+ Sbjct: 140 PPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTS---FAKSVIGTPEFMAPEMY--EE 194 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 Y VD+++ G E+AT + + SE +I+R + + Sbjct: 195 HYDESVDVYAFGMCMLEMATSEYPY---SECQNAAQIYRKVTS----------------- 234 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 KP AS K D +++ + + ++R+S + LNH +F + Sbjct: 235 ---GIKP---ASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 >3MV5-A nrPDB Length = 342 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 77/299 (25%), Positives = 138/299 (46%), Gaps = 49/299 (16%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES--EEEGVPSTAIREISLLKEL 58 M ++ ++ +G+GT+G V + K TG+ AMK ++ E ++ V T + E +L+ Sbjct: 9 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHT-LTENRVLQNS 67 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 RHP + +L+ RL + E+ + + + + + Y +I+ + + Sbjct: 68 RHPFLTALKYSFQTHDRLCFVMEYANGG--ELFFHLSRERVFSEDRARFYGAEIVSALDY 125 Query: 119 CHSRR-VLHRDLKPQNLLIDDKGTIKLADFGLARAF---GIPIRVYTHEVVTLWYRSPEV 174 HS + V++RDLK +NL++D G IK+ DFGL + G ++ + T Y +PEV Sbjct: 126 LHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCG---TPEYLAPEV 182 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 233 L + Y VD W +G + E+ + P ++ D E +LF + + E+ Sbjct: 183 LEDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHE--KLFELI---------LMEEIR- 229 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG-----KMALNHPYF 287 FP+ +L K+ LLS +L DP +R+ G K + H +F Sbjct: 230 -------FPR----TLGPEAKS-------LLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 270 >5O2C-A nrPDB Length = 380 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 76/290 (26%), Positives = 130/290 (44%), Gaps = 43/290 (14%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIV---- 64 ++G G + VYKG T VA +++ + E +LK L+HPNIV Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 91 Query: 65 SLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 S + +L + L+ E + S LK YL + M +++S+ QIL+G+ F H+R Sbjct: 92 SWESILKGKKCIVLVTELMTSGTLKTYLKRF---KVMKPKVLRSWCRQILKGLQFLHTRT 148 Query: 124 --VLHRDLKPQNLLIDD-KGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEVLLGSA 179 ++HRDLK N+ I G++K+ D GLA + V+ T + +PE+ Sbjct: 149 PPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTS---FAKSVIGTPEFMAPEMY--EE 203 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 Y VD+++ G E+AT + + SE +I+R + + Sbjct: 204 HYDESVDVYAFGMCMLEMATSEYPY---SECQNAAQIYRKVTS----------------- 243 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 KP AS K D +++ + + ++R+S + LNH +F + Sbjct: 244 ---GIKP---ASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 287 >3TKU-A nrPDB Length = 433 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 74/279 (26%), Positives = 122/279 (43%), Gaps = 41/279 (14%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRH 60 ED+ I+ IG G +G V + K T ++ AMK + + E + + E +L Sbjct: 90 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 149 Query: 61 PNIVSLQDVLMQDSRLYLIFEF-----LSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 I +L ++ LYL+ ++ L L K+ D +P + + Y+ +++ Sbjct: 150 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLP------EDMARFYIGEMVLA 203 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEV 174 I H +HRD+KP N+L+D G I+LADFG V + V T Y SPE+ Sbjct: 204 IDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEI 263 Query: 175 LL----GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPE 230 L G +Y D WS+G E+ + F+ +S ++ +I N+E Sbjct: 264 LQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIM------NHE---- 313 Query: 231 VESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLI 269 E Q FP SHV ++ E DL+ +++ Sbjct: 314 -ERFQ-----FP--------SHVTDVSEEAKDLIQRLIC 338 >4WUA-A nrPDB Length = 401 Score = 76.3 bits (186), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 99/372 (26%), Positives = 148/372 (39%), Gaps = 101/372 (27%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH--- 60 Y I K+G G + V+ + VAMK ++ E TA+ EI LLK +R+ Sbjct: 43 YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK---SAEHYTETALDEIRLLKSVRNSDP 99 Query: 61 --PN---IVSLQDVL----MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQ 111 PN +V L D + + + ++FE L L K++ Q + VK + Q Sbjct: 100 NDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIK-SNYQGLPLPCVKKIIQQ 158 Query: 112 ILQGIVFCHSR-RVLHRDLKPQNLLID--------------------------------- 137 +LQG+ + H++ R++H D+KP+N+L+ Sbjct: 159 VLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAP 218 Query: 138 ----------------DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 +K +K+AD G A + +T ++ T YRS EVL+GS Y Sbjct: 219 ATAGNFLVNPLEPKNAEKLKVKIADLGNACWVH---KHFTEDIQTRQYRSLEVLIGSG-Y 274 Query: 182 STPVDIWSIGTIFAELATKKPLF--HGDSEI----DQLFRIFRALGTPNNEVWPEVESLQ 235 +TP DIWS + ELAT LF H E D + I LG ++ + + + Sbjct: 275 NTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKL---IVAGK 331 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGL-------------------DLLSKMLIYDPAKRI 276 K F K G L H+ L GL D L ML P KR Sbjct: 332 YSKEFFT--KKGDL-KHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRA 388 Query: 277 SGKMALNHPYFN 288 + L HP+ N Sbjct: 389 TAAECLRHPWLN 400 >3I81-A nrPDB Length = 315 Score = 76.3 bits (186), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 55/212 (25%), Positives = 104/212 (49%), Gaps = 15/212 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTA----IREISLLKE 57 E T ++G+G++G+VY+G K + ++ +++ E + E S++KE Sbjct: 18 EKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKE 77 Query: 58 LRHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQ-- 114 ++V L V+ Q +I E ++ DLK YL S+ P + L L +++Q Sbjct: 78 FNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMA 137 Query: 115 -----GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP--IRVYTHEVVTL 167 G+ + ++ + +HRDL +N ++ + T+K+ DFG+ R R ++ + Sbjct: 138 GEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV 197 Query: 168 WYRSPEVLLGSARYSTPVDIWSIGTIFAELAT 199 + SPE L ++T D+WS G + E+AT Sbjct: 198 RWMSPESLKDGV-FTTYSDVWSFGVVLWEIAT 228 >4OLI-A nrPDB Length = 645 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 62/233 (26%), Positives = 110/233 (47%), Gaps = 23/233 (9%) Query: 6 KIEKIGEGTYGVV----YKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 KI +GEG +G V Y + TG++VA+K ++ + + S +EI +L+ L H Sbjct: 357 KIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHR-SGWKQEIDILRTLYHE 415 Query: 62 NIVSLQDVL--MQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 +I+ + + L L+ E++ + L+ YL P + + + + QI +G+ + Sbjct: 416 HIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL----PRHSIGLAQLLLFAQQICEGMAY 471 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT----HEVVTLWYRSPEV 174 HS+ +HR+L +N+L+D+ +K+ DFGLA+A Y + WY +PE Sbjct: 472 LHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWY-APEC 530 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEV 227 L ++ D+WS G EL T H DS + +G ++ Sbjct: 531 -LKEYKFYYASDVWSFGVTLYELLT-----HCDSSQSPPTKFLELIGIAQGQM 577 >6E4F-A nrPDB Length = 290 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 59/201 (29%), Positives = 109/201 (54%), Gaps = 15/201 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQV-VAMKKIRLESEEEGVPSTAIREISLLKELRH 60 +D T ++++G G +GVV G+ + GQ VA+K I+ S E I E ++ L H Sbjct: 31 KDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSE---DEFIEEAKVMMNLSH 85 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 +V L V + +++I E+++ L YL + ++ L++ + + + + Sbjct: 86 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRH-RFQTQQLLEM-CKDVCEAMEYL 143 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLW---YRSPEVLL 176 S++ LHRDL +N L++D+G +K++DFGL+R + YT V + + + PEVL+ Sbjct: 144 ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRY--VLDDEYTSSVGSKFPVRWSPPEVLM 201 Query: 177 GSARYSTPVDIWSIGTIFAEL 197 S ++S+ DIW+ G + E+ Sbjct: 202 YS-KFSSKSDIWAFGVLMWEI 221 >4C59-A nrPDB Length = 340 Score = 75.5 bits (184), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 61/226 (26%), Positives = 103/226 (45%), Gaps = 27/226 (11%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR-HPNIVSL-- 66 + EG + VY+ + +G+ A+K RL S EE I+E+ +K+L HPNIV Sbjct: 35 LAEGGFAFVYEAQDVGSGREYALK--RLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCS 92 Query: 67 ------QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 ++ + L+ E L ++L + + V YQ + + H Sbjct: 93 AASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMH 152 Query: 121 SRR--VLHRDLKPQNLLIDDKGTIKLADFGLAR--------AFGIPIRVYTHEVVTL--- 167 ++ ++HRDLK +NLL+ ++GTIKL DFG A ++ R E +T Sbjct: 153 RQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTT 212 Query: 168 -WYRSPEV--LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEI 210 YR+PE+ L + DIW++G I L ++ F +++ Sbjct: 213 PMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKL 258 >4PWN-A nrPDB Length = 274 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 64/219 (29%), Positives = 105/219 (47%), Gaps = 22/219 (10%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIV---- 64 +IG G++ VYKG T VA +++ + E +LK L+HPNIV Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYD 76 Query: 65 SLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 S + + + L+ E + S LK YL + M +++S+ QIL+G+ F H+R Sbjct: 77 SWESTVKGKKCIVLVTELMTSGTLKTYLKRF---KVMKIKVLRSWCRQILKGLQFLHTRT 133 Query: 124 --VLHRDLKPQNLLIDD-KGTIKLADFGLA----RAFGIPIRVYTHEVVTLWYRSPEVLL 176 ++HRDLK N+ I G++K+ D GLA RA + T E + +PE+ Sbjct: 134 PPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPE-----FMAPEMY- 187 Query: 177 GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFR 215 +Y VD+++ G E+AT + + Q++R Sbjct: 188 -EEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYR 225 >4Y93-A nrPDB Length = 446 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 56/199 (28%), Positives = 102/199 (51%), Gaps = 11/199 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQV-VAMKKIRLESEEEGVPSTAIREISLLKELRH 60 +D T ++++G G +GVV G+ + GQ VA+K I+ S E I E ++ L H Sbjct: 188 KDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSE---DEFIEEAKVMMNLSH 242 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 +V L V + +++I E+++ L YL + + + + + + + Sbjct: 243 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM--RHRFQTQQLLEMCKDVCEAMEYL 300 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLAR-AFGIPIRVYTHEVVTLWYRSPEVLLGS 178 S++ LHRDL +N L++D+G +K++DFG+ R T + + SPEVL+ S Sbjct: 301 ESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYS 360 Query: 179 ARYSTPVDIWSIGTIFAEL 197 ++S+ DIW+ G + E+ Sbjct: 361 -KFSSKSDIWAFGVLMWEI 378 >3A4O-X nrPDB Length = 286 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 60/234 (25%), Positives = 115/234 (49%), Gaps = 23/234 (9%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTA-----IREISLLKELRHP 61 ++++G G +G V+ G + + +V A+K ++ P T + E +L+K L+H Sbjct: 18 VKRLGAGQFGEVWMGYYNNSTKV-AVKTLK--------PGTMSVQAFLEEANLMKTLQHD 68 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 +V L V+ ++ +Y+I E+++ L +L S G+ + L+ + QI +G+ + Sbjct: 69 KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLI-DFSAQIAEGMAYIE 127 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHE---VVTLWYRSPEVLLG 177 + +HRDL+ N+L+ + K+ADFGLAR I YT + + +PE + Sbjct: 128 RKNYIHRDLRAANVLVSESLMCKIADFGLARV--IEDNEYTAREGAKFPIKWTAPEA-IN 184 Query: 178 SARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPE 230 ++ D+WS G + E+ T K + G + D + + + P E P+ Sbjct: 185 FGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPD 238 >4EBW-A nrPDB Length = 304 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 71/295 (24%), Positives = 134/295 (45%), Gaps = 50/295 (16%) Query: 10 IGEGTYGVVYKGRH---KTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 IGEG +G V++G + + VA+K + + V ++E +++ HP+IV L Sbjct: 46 IGEGQFGDVHQGIYMSPENPALAVAIKTCK-NCTSDSVREKFLQEALTMRQFDHPHIVKL 104 Query: 67 QDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQY-MDSSLVKSYLYQILQGIVFCHSRRV 124 V+ ++ +++I E ++ +L+ +L +Y +D + + Y YQ+ + + S+R Sbjct: 105 IGVITENP-VWIIMELCTLGELRSFLQV---RKYSLDLASLILYAYQLSTALAYLESKRF 160 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 +HRD+ +N+L+ +KL DFGL+R + ++ W +PE + R++ Sbjct: 161 VHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM-APES-INFRRFT 218 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 + D+W G E+ L HG G NN+V +E+ + + P Sbjct: 219 SASDVWMFGVCMWEI-----LMHGVKPFQ---------GVKNNDVIGRIENGE--RLPMP 262 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 P +L S L++K YDP++R P F +L Q+ + Sbjct: 263 PNCPPTLYS-----------LMTKCWAYDPSRR---------PRFTELKAQLSTI 297 >2J0K-A nrPDB Length = 656 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 71/294 (24%), Positives = 135/294 (45%), Gaps = 48/294 (16%) Query: 10 IGEGTYGVVYKGRH---KTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 IGEG +G V++G + + VA+K + + V ++E +++ HP+IV L Sbjct: 398 IGEGQFGDVHQGIYMSPENPAMAVAIKTCK-NCTSDSVREKFLQEALTMRQFDHPHIVKL 456 Query: 67 QDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 125 V+ ++ +++I E ++ +L+ +L +D + + Y YQ+ + + S+R + Sbjct: 457 IGVITENP-VWIIMELCTLGELRSFLQVRKFS--LDLASLILYAYQLSTALAYLESKRFV 513 Query: 126 HRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVLLGSARYST 183 HRD+ +N+L+ +KL DFGL+R + ++ W +PE + R+++ Sbjct: 514 HRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM-APES-INFRRFTS 571 Query: 184 PVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPK 243 D+W G E+ L HG + F+ G NN+V +E+ + + P Sbjct: 572 ASDVWMFGVCMWEI-----LMHG-------VKPFQ--GVKNNDVIGRIENGE--RLPMPP 615 Query: 244 WKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 P +L S L++K YDP++R P F +L Q+ + Sbjct: 616 NCPPTLYS-----------LMTKCWAYDPSRR---------PRFTELKAQLSTI 649 >3HKO-A nrPDB Length = 345 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 79/339 (23%), Positives = 126/339 (37%), Gaps = 79/339 (23%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR---EISLLKELRHPNIVSL 66 IG+G+YGVV T + A+K + + P R E+ L+K+L HPNI L Sbjct: 34 IGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLHHPNIARL 93 Query: 67 QDVLMQDSRLYLIFEF-----LSMDLKKYLDSIPPGQYMD-------------------- 101 +V + + L+ E L L ++D MD Sbjct: 94 YEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNEEAINGS 153 Query: 102 -------------SSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGT--IKLAD 146 L+ + + QI + + H++ + HRD+KP+N L + IKL D Sbjct: 154 IHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKSFEIKLVD 213 Query: 147 FGLARAF----GIPIRVYTHEVVTLWYRSPEVL-LGSARYSTPVDIWSIGTIFAELATKK 201 FGL++ F T + T ++ +PEVL + Y D WS G + L Sbjct: 214 FGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVLLHLLLMGA 273 Query: 202 PLFHGDSEIDQLFRIFR---ALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDE 258 F G ++ D + ++ PN V + Sbjct: 274 VPFPGVNDADTISQVLNKKLCFENPNYNVLSPLAR------------------------- 308 Query: 259 NGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 DLLS +L + +R AL HP+ + ++I KM Sbjct: 309 ---DLLSNLLNRNVDERFDAMRALQHPWISQFSDKIYKM 344 >1U54-B nrPDB Length = 291 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 60/208 (28%), Positives = 101/208 (48%), Gaps = 16/208 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGR-----HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLK 56 +D +EK+G+G++GVV +G KT V K + S+ E + IRE++ + Sbjct: 18 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAM-DDFIREVNAMH 76 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPP--GQYMDSSLVKSYLYQILQ 114 L H N++ L V++ + ++ E L LD + G ++ +L + Y Q+ + Sbjct: 77 SLDHRNLIRLYGVVLTPP-MKMVTELAP--LGSLLDRLRKHQGHFLLGTLSR-YAVQVAE 132 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT---HEVVTLWYRS 171 G+ + S+R +HRDL +NLL+ + +K+ DFGL RA Y H V + + Sbjct: 133 GMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 192 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELAT 199 PE L + +S D W G E+ T Sbjct: 193 PES-LKTRTFSHASDTWMFGVTLWEMFT 219 >4HZS-A nrPDB Length = 341 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 60/208 (28%), Positives = 101/208 (48%), Gaps = 16/208 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGR-----HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLK 56 +D +EK+G+G++GVV +G KT V K + S+ E + IRE++ + Sbjct: 12 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAM-DDFIREVNAMH 70 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPP--GQYMDSSLVKSYLYQILQ 114 L H N++ L V++ + ++ E L LD + G ++ +L + Y Q+ + Sbjct: 71 SLDHRNLIRLYGVVLTPP-MKMVTELAP--LGSLLDRLRKHQGHFLLGTLSR-YAVQVAE 126 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT---HEVVTLWYRS 171 G+ + S+R +HRDL +NLL+ + +K+ DFGL RA Y H V + + Sbjct: 127 GMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCA 186 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELAT 199 PE L + +S D W G E+ T Sbjct: 187 PES-LKTRTFSHASDTWMFGVTLWEMFT 213 >5X5O-A nrPDB Length = 310 Score = 74.3 bits (181), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 104/211 (49%), Gaps = 20/211 (9%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELR 59 +D E G G++G VY+ + + + VA+KK+ ++E E E +L L Sbjct: 14 FDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAE-----------ILSVLS 62 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 H NI+ V+++ ++ E+ S+ L Y++S + MD + ++ + +G+ + Sbjct: 63 HRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINS-NRSEEMDMDHIMTWATDVAKGMHY 121 Query: 119 CHSR---RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 H +V+HRDLK +N++I G +K+ DFG +R + V T + +PEV Sbjct: 122 LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSL--VGTFPWMAPEV- 178 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHG 206 + S S D +S G + E+ T++ F G Sbjct: 179 IQSLPVSETCDTYSYGVVLWEMLTREVPFKG 209 >6J5U-C nrPDB Length = 426 Score = 73.9 bits (180), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 100/208 (48%), Gaps = 22/208 (10%) Query: 10 IGEGTYGVVYKG---------RHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 +GEG +G V+KG +G VVA+K+++ E + + E++ L +L H Sbjct: 92 LGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGH--KEWLTEVNYLGQLSH 149 Query: 61 PNIVSLQDVLMQDSRLYLIFEFL---SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 PN+V L + L++EF+ S++ + P + ++ +G+ Sbjct: 150 PNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQP---LTWAIRMKVAVGAAKGLT 206 Query: 118 FCHSRR--VLHRDLKPQNLLIDDKGTIKLADFGLARA--FGIPIRVYTHEVVTLWYRSPE 173 F H + V++RD K N+L+D KL+DFGLA+A G V T + T Y +PE Sbjct: 207 FLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGYAAPE 266 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKK 201 + + R + D++S G + EL + + Sbjct: 267 -YVATGRLTAKSDVYSFGVVLLELISGR 293 >2JD5-A nrPDB Length = 373 Score = 73.6 bits (179), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 93/343 (27%), Positives = 137/343 (39%), Gaps = 81/343 (23%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN- 62 Y + K+G G + V+ + VAMK +R ++ A EI LL+ + + Sbjct: 21 YILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR---GDKVYTEAAEDEIKLLQRVNDADN 77 Query: 63 ----------IVSLQDVLMQDS----RLYLIFEFLSMDL----KKYLDSIPPGQYMDSSL 104 I+ L D + ++FE L +L KKY P Y Sbjct: 78 TKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIY----- 132 Query: 105 VKSYLYQILQGIVFCHSR-RVLHRDLKPQNLLIDDKGT------IKLADFGLARAFGIPI 157 VK Q+L G+ + H R ++H D+KP+N+L++ + IK+AD G A + Sbjct: 133 VKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYD--- 189 Query: 158 RVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFH---------GDS 208 YT+ + T YRSPEVLLG A + DIWS + EL T LF D Sbjct: 190 EHYTNSIQTREYRSPEVLLG-APWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDD 248 Query: 209 EIDQLFRI------------------FRALGTPNN----EVWPEVESLQDYKNTFPKWKP 246 I Q+ + F + G N + WP +E + K F K + Sbjct: 249 HIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWP-LEDVLTEKYKFSKDEA 307 Query: 247 GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 ++ D LS ML DP KR +NHP+ D Sbjct: 308 KEIS-----------DFLSPMLQLDPRKRADAGGLVNHPWLKD 339 >3C51-A nrPDB Length = 543 Score = 73.6 bits (179), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 78/295 (26%), Positives = 131/295 (44%), Gaps = 46/295 (15%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVP-STAIREISLLKELRHPNIVSLQD 68 +G G +G V+ + K TG++ A KK+ + ++ A+ E +L ++ IVSL Sbjct: 193 LGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAY 252 Query: 69 VLMQDSRLYLIFEFLSMDLKKY----LDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 124 + L L+ ++ +Y +D PG ++ Y QI+ G+ H R + Sbjct: 253 AFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIF--YTAQIVSGLEHLHQRNI 310 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTP 184 ++RDLKP+N+L+DD G ++++D GLA T + +PE+LLG Y Sbjct: 311 IYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGE-EYDFS 369 Query: 185 VDIWSIG-TIFAELATKKPLFHGDSEIDQLFRIFRALG--TPNNEVWPEVESLQDYKNTF 241 VD +++G T++ +A + P FRA G N E+ + + + T+ Sbjct: 370 VDYFALGVTLYEMIAARGP--------------FRARGEKVENKEL---KQRVLEQAVTY 412 Query: 242 P-KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALNHPYFNDL 290 P K+ P S D +L DP KR+ S HP F D+ Sbjct: 413 PDKFSPAS------------KDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDI 455 >1VZO-A nrPDB Length = 355 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 67/285 (23%), Positives = 136/285 (47%), Gaps = 35/285 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKT---TGQVVAMKKIRLESEEEGVPST--AIREISLL 55 +E++ ++ +G G YG V+ R + TG++ AMK ++ + + +T E +L Sbjct: 53 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 112 Query: 56 KELRH-PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 + +R P +V+L +++L+LI ++++ + + + V+ Y+ +I+ Sbjct: 113 EHIRQSPFLVTLHYAFQTETKLHLILDYINGG--ELFTHLSQRERFTEHEVQIYVGEIVL 170 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPE 173 + H +++RD+K +N+L+D G + L DFGL++ F ++ T+ Y +P+ Sbjct: 171 ALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPD 230 Query: 174 VLLGS-ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 ++ G + + VD WS+G + EL T F D E + I R + ++ Sbjct: 231 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRI----------LK 280 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS 277 S Y P +++ K DL+ ++L+ DP KR+ Sbjct: 281 SEPPY--------PQEMSALAK-------DLIQRLLMKDPKKRLG 310 >3NYO-A nrPDB Length = 576 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 73/293 (24%), Positives = 137/293 (46%), Gaps = 43/293 (14%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGV-PSTAIREISLLKELRHPNIVSLQD 68 +G+G +G V + + TG++ A KK+ + ++ + A+ E +L+++ +VSL Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251 Query: 69 VLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHR 127 L L+ ++ DLK ++ + + ++ V Y +I G+ H R+++R Sbjct: 252 AYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAV-FYAAEICCGLEDLHRERIVYR 310 Query: 128 DLKPQNLLIDDKGTIKLADFGLARAFGIPI-RVYTHEVVTLWYRSPEVLLGSARYSTPVD 186 DLKP+N+L+DD G I+++D GL A +P + V T+ Y +PEV + + RY+ D Sbjct: 311 DLKPENILLDDHGHIRISDLGL--AVHVPEGQTIKGRVGTVGYMAPEV-VKNERYTFSPD 367 Query: 187 IWSIGTIFAEL-ATKKPLFHGDSEI--DQLFRIFRALGTPNNEVWPEVESLQDYKNTFPK 243 W++G + E+ A + P +I +++ R+ + E ++Y F Sbjct: 368 WWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVK-------------EVPEEYSERF-- 412 Query: 244 WKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALNHPYFNDLD 291 L S++L DPA+R+ S + HP F L+ Sbjct: 413 -------------SPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 >4K33-A nrPDB Length = 325 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 56/233 (24%), Positives = 115/233 (49%), Gaps = 26/233 (11%) Query: 10 IGEGTYGVVYKGR-------HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHP 61 +GEG +G V VA+K ++ ++ ++ + S + E+ ++K + +H Sbjct: 44 LGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDL-SDLVSEMEMMKMIGKHK 102 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSM-DLKKYL-------------DSIPPGQYMDSSLVKS 107 NI++L Q LY++ E+ + +L+++L S PP + + + S Sbjct: 103 NIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQLTFKDLVS 162 Query: 108 YLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP--IRVYTHEVV 165 YQ+ +G+ + S++ +HRDL +N+L+ + +K+ADFGLAR + T+ + Sbjct: 163 CAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKETTNGRL 222 Query: 166 TLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 218 + + +PE L Y+ D+WS G + E+ T + +++LF++ + Sbjct: 223 PVKWMAPEALFDRV-YTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLK 274 >3FXW-A nrPDB Length = 336 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 82/304 (26%), Positives = 120/304 (39%), Gaps = 73/304 (24%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMK------KIRLESEEEGVPSTAIREISLLKELRHPNI 63 +G G G V + H+ TGQ A+K K R E + S P+I Sbjct: 37 LGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGG------------PHI 84 Query: 64 VSLQDVL--MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ----GIV 117 V + DV M + L+ M+ + I + D + + +I++ I Sbjct: 85 VCILDVYENMHHGKRCLLIIMECMEGGELFSRIQ--ERGDQAFTEREAAEIMRDIGTAIQ 142 Query: 118 FCHSRRVLHRDLKPQNLLIDDK---GTIKLADFGLAR-----AFGIPIRVYTHEVVTLWY 169 F HS + HRD+KP+NLL K +KL DFG A+ A P T +Y Sbjct: 143 FLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTP-------CYTPYY 195 Query: 170 RSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFH---GDSEIDQLFRIFR--ALGTPN 224 +PEV LG +Y D+WS+G I L P F+ G + + R R G PN Sbjct: 196 VAPEV-LGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPN 254 Query: 225 NEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNH 284 E W EV E+ L+ +L DP +R++ +NH Sbjct: 255 PE-WSEV-------------------------SEDAKQLIRLLLKTDPTERLTITQFMNH 288 Query: 285 PYFN 288 P+ N Sbjct: 289 PWIN 292 >4I6B-A nrPDB Length = 308 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 56/217 (25%), Positives = 100/217 (46%), Gaps = 7/217 (3%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAI-REISLLKELRHPN 62 Y++ + +G+G + Y+ T +V A K I + I +EI L + L H + Sbjct: 30 YSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHKH 89 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 +V +Y++ E+ S ++ + + + V+ YL QI+ G+ + H + Sbjct: 90 VVQFYHYFEDKENIYILLEYCSRRSMAHI--LKARKVLTEPEVRYYLRQIVSGLKYLHEQ 147 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV-TLWYRSPEVLLGSARY 181 +LHRDLK N I++ +K+ DFGLA P+ + T Y SPEV L + Sbjct: 148 EILHRDLKLGNFFINESMELKVGDFGLAARLE-PLEHRRRTICGTPNYLSPEV-LNKQGH 205 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 218 DIW++G + + +P F + + + +R R Sbjct: 206 GAESDIWALGCVMYTMLLGRPPFE-TTNLKETYRSIR 241 >6HV0-A nrPDB Length = 416 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 78/298 (26%), Positives = 125/298 (41%), Gaps = 46/298 (15%) Query: 10 IGEGTYG-VVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHPNIVSLQ 67 +G G G +VY+G VA+K+I E S A RE+ LL+E HPN++ Sbjct: 16 LGHGAEGTIVYRGMFDNRD--VAVKRILPECF-----SFADREVQLLRESDEHPNVIRYF 68 Query: 68 DVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHR 127 Y+ E + L++Y++ + + L Q G+ HS ++HR Sbjct: 69 CTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPI--TLLQQTTSGLAHLHSLNIVHR 126 Query: 128 DLKPQNLLI---DDKGTIK--LADFGLARAFGIPIRVYTHEV---VTLWYRSPEVLLGSA 179 DLKP N+LI + G IK ++DFGL + + ++ T + +PE+L Sbjct: 127 DLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDC 186 Query: 180 RY--STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 + + VDI+S G +F + ++ P +SLQ Sbjct: 187 KENPTYTVDIFSAGCVFYYVISEGS-------------------------HPFGKSLQRQ 221 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIK 295 N K+ D +L+ KM+ DP KR S K L HP+F L+ Q++ Sbjct: 222 ANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQ 279 >6FEX-A nrPDB Length = 321 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 106/219 (48%), Gaps = 31/219 (14%) Query: 8 EKIGEGTYGVVYKGR----------------HKTTGQVVAMKKIRLESEEEGVPSTAIRE 51 EK+GEG +G V+ K +VA+K +R ++ + + ++E Sbjct: 22 EKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR-NDFLKE 80 Query: 52 ISLLKELRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYL------DSIPPGQYMDSSL 104 + ++ L+ PNI+ L V +QD L +I +++ + DL ++L D G D ++ Sbjct: 81 VKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDPTI 140 Query: 105 VKSYLY----QILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIR 158 L QI G+ + + +HRDL +N L+ + TIK+ADFG++R G R Sbjct: 141 SYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYR 200 Query: 159 VYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL 197 V V+ + + + E +L +++T D+W+ G E+ Sbjct: 201 VQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEV 238 >3C1X-A nrPDB Length = 373 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 103/210 (49%), Gaps = 29/210 (13%) Query: 8 EKIGEGTYGVVYKGR------HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E IG G +G VY G K V ++ +I + G S + E ++K+ HP Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRI----TDIGEVSQFLTEGIIMKDFSHP 150 Query: 62 NIVSLQDVLM--QDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 N++SL + + + S L ++ DL+ ++ + + + + Q+ +G+ F Sbjct: 151 NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLI--GFGLQVAKGMKFL 208 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL---- 175 S++ +HRDL +N ++D+K T+K+ADFGLAR +Y E ++ ++ L Sbjct: 209 ASKKFVHRDLAARNCMLDEKFTVKVADFGLAR------DMYDKEFDSVHNKTGAKLPVKW 262 Query: 176 -----LGSARYSTPVDIWSIGTIFAELATK 200 L + +++T D+WS G + EL T+ Sbjct: 263 MALESLQTQKFTTKSDVWSFGVLLWELMTR 292 >5O0Y-A nrPDB Length = 579 Score = 72.8 bits (177), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 64/220 (29%), Positives = 102/220 (46%), Gaps = 26/220 (11%) Query: 15 YGVVYKGRHKTTGQVVAMKKIRL-----ESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 + VYK T + VA+K +L + ++E A RE + KEL HP IV L D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 70 LMQDSRLYL-IFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR--VL 125 D+ + + E+ DL YL + M +S + QI+ + + + + ++ Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQ---HKLMSEKEARSIIMQIVNALKYLNEIKPPII 413 Query: 126 HRDLKPQNLLIDDK---GTIKLADFGLARAFGIP-------IRVYTHEVVTLWYRSPEVL 175 H DLKP N+L+ + G IK+ DFGL++ + + + T WY PE Sbjct: 414 HYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECF 473 Query: 176 L---GSARYSTPVDIWSIGTIFAE-LATKKPLFHGDSEID 211 + + S VD+WS+G IF + L +KP H S+ D Sbjct: 474 VVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQD 513 >4PL5-B nrPDB Length = 435 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 78/298 (26%), Positives = 128/298 (42%), Gaps = 46/298 (15%) Query: 10 IGEGTYG-VVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHPNIVSLQ 67 +G G G +VYKG VA+K+I E S A RE+ LL+E HPN++ Sbjct: 35 LGHGAEGTIVYKGMFDNRD--VAVKRILPECF-----SFADREVQLLRESDEHPNVIRYF 87 Query: 68 DVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHR 127 Y+ E + L++Y++ + + L+Q G+ HS ++HR Sbjct: 88 CTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPI--TLLHQTTSGLAHLHSLNIVHR 145 Query: 128 DLKPQNLLI---DDKGTIK--LADFGLARAFGIPIRVYTHEV---VTLWYRSPEVLLGSA 179 DLKP N+L+ + G IK ++DFGL + + ++ T + +PE+L Sbjct: 146 DLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDC 205 Query: 180 R--YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 + + VDI+S G +F + ++ +H P +SLQ Sbjct: 206 KDNPTYTVDIFSAGCVFYYVISEG--YH-----------------------PFGKSLQRQ 240 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIK 295 N K+ D +L+ KM+ DP +R S K L HP+F L+ Q++ Sbjct: 241 ANILLGACNLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQLQ 298 >3ORP-A nrPDB Length = 311 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 48/177 (27%), Positives = 82/177 (46%), Gaps = 12/177 (6%) Query: 50 REISLLKELRHPNIVSLQDVLMQDSRL----YLIFEFL-SMDLKKYLDSIPPGQYMDSSL 104 RE L HP IV++ D ++ Y++ E++ + L+ + + P M Sbjct: 61 REAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGP---MTPKR 117 Query: 105 VKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF---GIPIRVYT 161 + Q + F H ++HRD+KP N++I +K+ DFG+ARA G + Sbjct: 118 AIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTA 177 Query: 162 HEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 218 + T Y SPE G + D++S+G + E+ T +P F GDS + ++ R Sbjct: 178 AVIGTAQYLSPEQARGDS-VDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVR 233 >4G3E-A nrPDB Length = 352 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 59/195 (30%), Positives = 94/195 (48%), Gaps = 24/195 (12%) Query: 5 TKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIV 64 T ++G G++G V++ + K TG A+KK+RLE + E+ L P IV Sbjct: 77 THQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEV-------FRVEELVACAGLSSPRIV 129 Query: 65 SLQDVLMQDSRLYLIFEFLSM----DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 L + + + + E L L K + +P D +L YL Q L+G+ + H Sbjct: 130 PLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPE----DRALY--YLGQALEGLEYLH 183 Query: 121 SRRVLHRDLKPQNLLIDDKGT-IKLADFGLARAF---GIPIRVYTHEVV--TLWYRSPEV 174 +RR+LH D+K N+L+ G+ L DFG A G+ + T + + T + +PEV Sbjct: 184 TRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEV 243 Query: 175 LLGSARYSTPVDIWS 189 ++G VDIWS Sbjct: 244 VMGKP-CDAKVDIWS 257 >4RC3-A nrPDB Length = 289 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 61/216 (28%), Positives = 99/216 (45%), Gaps = 10/216 (4%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKI---RLESEEEGVPSTAI-REISLLKELRH--PNI 63 +G G +G VY G + VA+K + R+ E T + E+ LLK++ + Sbjct: 20 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 79 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 + L D + LI E ++ D I + L +S+ +Q+L+ + CH+ Sbjct: 80 IRLLDWFERPDSFVLILE-RPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 138 Query: 124 VLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 VLHRD+K +N+LID ++G +KL DFG + VYT T Y PE + + Sbjct: 139 VLHRDIKDENILIDLNRGELKLIDFGSGAL--LKDTVYTDFDGTRVYSPPEWIRYHRYHG 196 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 218 +WS+G + ++ F D EI + FR Sbjct: 197 RSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR 232 >3BGP-A nrPDB Length = 333 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 61/216 (28%), Positives = 99/216 (45%), Gaps = 10/216 (4%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKI---RLESEEEGVPSTAI-REISLLKELRH--PNI 63 +G G +G VY G + VA+K + R+ E T + E+ LLK++ + Sbjct: 64 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 123 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 + L D + LI E ++ D I + L +S+ +Q+L+ + CH+ Sbjct: 124 IRLLDWFERPDSFVLILE-RPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 182 Query: 124 VLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 VLHRD+K +N+LID ++G +KL DFG + VYT T Y PE + + Sbjct: 183 VLHRDIKDENILIDLNRGELKLIDFGSGAL--LKDTVYTDFDGTRVYSPPEWIRYHRYHG 240 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 218 +WS+G + ++ F D EI + FR Sbjct: 241 RSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR 276 >4NEU-A nrPDB Length = 333 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 58/238 (24%), Positives = 114/238 (47%), Gaps = 21/238 (8%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D+ + ++ G +G V H+T G ++ MK + + E ++ LRH Sbjct: 25 DFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNRLRHSR 83 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 +V L V++++ + L+ E+ M+ + + S+ + +I++G+ + H + Sbjct: 84 VVKLLGVIIEEGKYSLVMEY--MEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGK 141 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV--------------TLW 168 V+H+DLKP+N+L+D+ IK+AD GLA +F + ++ E TL+ Sbjct: 142 GVIHKDLKPENILVDNDFHIKIADLGLA-SFKMWSKLNNEEHNELREVDGTAKKNGGTLY 200 Query: 169 YRSPEVLLG-SARYSTPVDIWSIGTI-FAELATKKPLFHGDSEIDQLFRIFRALGTPN 224 Y +PE L +A+ + D++S + +A A K+P + E QL ++ P+ Sbjct: 201 YMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICE-QQLIMCIKSGNRPD 257 >4X7Q-B nrPDB Length = 312 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 63/226 (27%), Positives = 98/226 (43%), Gaps = 16/226 (7%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVP----STAIREISLLKELR----HP 61 +G+G +G V+ G T VA+K I P T E++LL ++ HP Sbjct: 39 LGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHP 98 Query: 62 NIVSLQDVLMQDSRLYLIFE--FLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 ++ L D L+ E + DL Y+ P + + + Q++ I C Sbjct: 99 GVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGP---LGEGPSRCFFGQVVAAIQHC 155 Query: 120 HSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 HSR V+HRD+K +N+LID +G KL DFG YT T Y PE + Sbjct: 156 HSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLH--DEPYTDFDGTRVYSPPEWISRH 213 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPN 224 ++ P +WS+G + ++ F D EI + F A +P+ Sbjct: 214 QYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPD 259 >5MJB-A nrPDB Length = 305 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 66/258 (25%), Positives = 127/258 (49%), Gaps = 21/258 (8%) Query: 4 YTKIEK-IGEGTYGVVYKGRHKTTGQ---VVAMKKIRLESEEEGVPSTAIREISLLKELR 59 + KIE+ IG G +G VYKGR K G+ VA+K ++ E+ + E S++ + Sbjct: 27 FVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQ-RRDFLSEASIMGQFD 85 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 H NI+ L+ V+ + + +I EF+ + L +L GQ+ LV L I G+ + Sbjct: 86 HRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQ-NDGQFTVIQLV-GMLRGIAAGMKY 143 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--VYTHEV---VTLWYRSPE 173 +HRDL +N+L++ K++DFGL+R YT + + + + +PE Sbjct: 144 LSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPE 203 Query: 174 VLLGSARYSTPVDIWSIGTIFAELAT--KKPLFHGDSE-----IDQLFRIFRALGTPNNE 226 + ++++ D+WS G + E+ + ++P + ++ I+Q +R+ + P Sbjct: 204 A-IAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAAL 262 Query: 227 VWPEVESLQDYKNTFPKW 244 ++ Q +N+ P++ Sbjct: 263 HQLMLDCWQKDRNSRPRF 280 >3DKO-A nrPDB Length = 318 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 56/201 (27%), Positives = 100/201 (49%), Gaps = 10/201 (4%) Query: 6 KIEK-IGEGTYGVVYKGRHKTTGQ---VVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 KIE+ IG G +G V GR K G+ VA+K +++ E+ + E S++ + HP Sbjct: 46 KIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQ-RRDFLCEASIMGQFDHP 104 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 N+V L+ V+ + + ++ EF+ GQ+ LV L I G+ + Sbjct: 105 NVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLV-GMLRGIAAGMRYLAD 163 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHE--VVTLWYRSPEVLLGS 178 +HRDL +N+L++ K++DFGL+R P VYT + + + +PE + Sbjct: 164 MGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQ-Y 222 Query: 179 ARYSTPVDIWSIGTIFAELAT 199 ++++ D+WS G + E+ + Sbjct: 223 RKFTSASDVWSYGIVMWEVMS 243 >2VD5-A nrPDB Length = 412 Score = 71.6 bits (174), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 67/226 (29%), Positives = 105/226 (46%), Gaps = 15/226 (6%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRH 60 +D+ ++ IG G + V + K TGQV AMK + + + + G S E +L Sbjct: 61 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 120 Query: 61 PNIVSLQDVLMQDSRLYLIFEF-LSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 I L ++ LYL+ E+ + DL L G+ + + + + YL +I+ I Sbjct: 121 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKF--GERIPAEMARFYLAEIVMAIDSV 178 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLA---RAFGIPIRVYTHEVVTLWYRSPEVLL 176 H +HRD+KP N+L+D G I+LADFG RA G +R V T Y SPE+L Sbjct: 179 HRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGT-VRSLV-AVGTPDYLSPEILQ 236 Query: 177 G------SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRI 216 + Y D W++G E+ + F+ DS + +I Sbjct: 237 AVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKI 282 >2DQ7-X nrPDB Length = 283 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 59/221 (26%), Positives = 108/221 (48%), Gaps = 19/221 (8%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 I+++G G +G V+ G +V A+K ++ + P + + E ++K+L+H +V L Sbjct: 14 IKRLGNGQFGEVWMGTWNGNTKV-AIKTLKPGTMS---PESFLEEAQIMKKLKHDKLVQL 69 Query: 67 QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSL--VKSYLYQILQGIVFCHSRRV 124 V+ ++ +Y++ E+ M+ LD + G+ L + Q+ G+ + Sbjct: 70 YAVVSEEP-IYIVTEY--MNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNY 126 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV---VTLWYRSPEVLLGSARY 181 +HRDL+ N+L+ + K+ADFGLAR I YT + + +PE L R+ Sbjct: 127 IHRDLRSANILVGNGLICKIADFGLARL--IEDNEYTARQGAKFPIKWTAPEAAL-YGRF 183 Query: 182 STPVDIWSIGTIFAELATKK----PLFHGDSEIDQLFRIFR 218 + D+WS G + EL TK P + ++Q+ R +R Sbjct: 184 TIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYR 224 >6BXI-A nrPDB Length = 333 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 74/258 (28%), Positives = 105/258 (40%), Gaps = 67/258 (25%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIR----LESEEEGVPSTAIR-EISLL 55 +ED+ ++ IG G +G V + K TG V AMK +R LE E+ G IR E +L Sbjct: 5 LEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVG----HIRAERDIL 60 Query: 56 KELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKS-------- 107 E +V + LYLI EFL PG M + L+K Sbjct: 61 VEADSLWVVKMFYSFQDKLNLYLIMEFL------------PGGDMMTLLMKKDTLTEEET 108 Query: 108 --YLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV------ 159 Y+ + + I H +HRD+KP NLL+D KG +KL+DFGL R Sbjct: 109 QFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNL 168 Query: 160 -------YTHE----------------------VVTLWYRSPEVLLGSARYSTPVDIWSI 190 +T + V T Y +PEV + + Y+ D WS+ Sbjct: 169 NHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-YNKLCDWWSL 227 Query: 191 GTIFAELATKKPLFHGDS 208 G I E+ P F ++ Sbjct: 228 GVIMYEMLIGYPPFCSET 245 >6BFN-A nrPDB Length = 342 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 63/214 (29%), Positives = 100/214 (46%), Gaps = 28/214 (13%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE--GVPSTAIREISLLKELRH 60 ++++ KIGEG +G VY+ + T V A+K+++ ++ E V + + E+ L RH Sbjct: 23 NFSEELKIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRH 80 Query: 61 PNIVSLQDVLMQDSRLYLIFEFL---SMD--LKKYLDSIPP---GQYMDSSLVKSYLYQI 112 PNIV Q+ L++ FL S++ L + PP Q +D L Sbjct: 81 PNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLD------ILLGT 134 Query: 113 LQGIVFCH--SRRVLHRDLKPQNLLIDDKGTIKLADFGLAR----AFGIPIR----VYTH 162 + I F H S ++H D+K N+L+D++ T KL DFGLAR A P + T Sbjct: 135 ARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQ 194 Query: 163 EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAE 196 V PE + + R + D +S G + E Sbjct: 195 TVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLE 228 >5TUR-A nrPDB Length = 404 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 61/216 (28%), Positives = 99/216 (45%), Gaps = 10/216 (4%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKI---RLESEEEGVPSTAI-REISLLKELRH--PNI 63 +G G +G VY G + VA+K + R+ E T + E+ LLK++ + Sbjct: 135 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 194 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 + L D + LI E ++ D I + L +S+ +Q+L+ + CH+ Sbjct: 195 IRLLDWFERPDSFVLILE-RPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 253 Query: 124 VLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 VLHRD+K +N+LID ++G +KL DFG + VYT T Y PE + + Sbjct: 254 VLHRDIKDENILIDLNRGELKLIDFGSGAL--LKDTVYTDFDGTRVYSPPEWIRYHRYHG 311 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 218 +WS+G + ++ F D EI + FR Sbjct: 312 RSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR 347 >3V5Q-A nrPDB Length = 297 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 66/242 (27%), Positives = 111/242 (45%), Gaps = 33/242 (13%) Query: 9 KIGEGTYGVVYKG--------RHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++GEG +G V+ + K V A+K L + ++ RE LL L+H Sbjct: 22 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKD-----FQREAELLTNLQH 76 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPP-------GQYMDS------SLVK 106 +IV V L ++FE++ DL K+L + P GQ + S + Sbjct: 77 EHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQML 136 Query: 107 SYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP--IRVYTHEV 164 QI G+V+ S+ +HRDL +N L+ +K+ DFG++R RV H + Sbjct: 137 HIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTM 196 Query: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT--KKPLFH-GDSEIDQLFRIFRALG 221 + + + PE ++ +++T D+WS G I E+ T K+P F ++E+ + R L Sbjct: 197 LPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLE 255 Query: 222 TP 223 P Sbjct: 256 RP 257 >5AMN-A nrPDB Length = 299 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 61/216 (28%), Positives = 101/216 (46%), Gaps = 39/216 (18%) Query: 10 IGEGTYGVVYK-------GRHKTTGQVVAMKKIRLESEEEGVPSTA---IREISLLKELR 59 +GEG +G V K GR T V M K E PS + E ++LK++ Sbjct: 31 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK------ENASPSELRDLLSEFNVLKQVN 84 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDS---IPPGQYMDSSLVK----SYLYQ 111 HP+++ L QD L LI E+ L+ +L + PG + +L S+ +Q Sbjct: 85 HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQ 144 Query: 112 ILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV------- 164 I QG+ + +++HRDL +N+L+ + +K++DFGL+R VY + Sbjct: 145 ISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRD------VYEEDSYVKRSQG 198 Query: 165 -VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT 199 + + + + E L Y+T D+WS G + E+ T Sbjct: 199 RIPVKWMAIESLFDHI-YTTQSDVWSFGVLLWEIVT 233 >5XD6-A nrPDB Length = 305 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 58/217 (26%), Positives = 106/217 (48%), Gaps = 18/217 (8%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++Y IGEG+YG V+ G K+ G+ A+KK+ + + + ++S++ LR Sbjct: 22 DNYGSKSLIGEGSYGRVFYGILKS-GKAAAIKKLDSSKQPD---QEFLAQVSMVSRLRQE 77 Query: 62 NIVSLQDVLMQDSRLYLIFEFLS-------MDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 N+V+L + L +E+ + +K + PG + + Sbjct: 78 NVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAAR 137 Query: 115 GIVFCHSR---RVLHRDLKPQNLLIDDKGTIKLADFGLA-RAFGIPIRVYTHEVV-TLWY 169 G+ + H + V+HRD+K N+L+ D K+ADF L+ +A + R+++ V+ T Y Sbjct: 138 GLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGY 197 Query: 170 RSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFH 205 +PE + + ST D++S G + EL T +KP+ H Sbjct: 198 HAPEYAM-TGTLSTKSDVYSFGVVLLELLTGRKPVDH 233 >2VWV-A nrPDB Length = 302 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 96/215 (44%), Gaps = 32/215 (14%) Query: 4 YTKIEK-IGEGTYGVVYKGRHKTTGQ---VVAMKKIRLESEEEGVPSTAIREISLLKELR 59 Y KIE+ IG G +G V +GR K G+ VA+K ++ E + E S++ + Sbjct: 17 YVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLK-GGYTERQRREFLSEASIMGQFE 75 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HPNI+ L+ V+ + ++ EF+ + GQ+ LV L I G+ + Sbjct: 76 HPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLV-GMLRGIASGMRYL 134 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLAR-------------AFG--IPIRVYTHEV 164 +HRDL +N+L++ K++DFGL+R + G IPIR E Sbjct: 135 AEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEA 194 Query: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT 199 + ++++ D WS G + E+ + Sbjct: 195 IAF-----------RKFTSASDAWSYGIVMWEVMS 218 >4YHJ-A nrPDB Length = 584 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 73/290 (25%), Positives = 135/290 (46%), Gaps = 37/290 (12%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGV-PSTAIREISLLKELRHPNIVSLQD 68 +G+G +G V + + TG++ A KK++ + ++ + A+ E +L++++ +VSL Sbjct: 193 LGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAY 252 Query: 69 VLMQDSRLYLIFEFLSM-DLKKYLDSIP-PGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 L L+ ++ DLK ++ ++ PG D Y ++ G+ R+++ Sbjct: 253 AYETKDALCLVLTIMNGGDLKFHIYNLGNPG--FDEQRAVFYAAELCCGLEDLQRERIVY 310 Query: 127 RDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVD 186 RDLKP+N+L+DD+G I+++D GLA RV V T+ Y +PEV + + +Y+ D Sbjct: 311 RDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGR-VGTVGYMAPEV-VNNEKYTFSPD 368 Query: 187 IWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP 246 W +G + E+ F E + W EV+ Q KN Sbjct: 369 WWGLGCLIYEMIQGHSPFKKYKEKVK---------------WEEVD--QRIKN------- 404 Query: 247 GSLASHVKNLDENGLDLLSKMLIYDPAKRIS--GKMAL---NHPYFNDLD 291 + + E+ + +L +P+KR+ G+ A HP F D++ Sbjct: 405 -DTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDIN 453 >5L6P-A nrPDB Length = 298 Score = 70.5 bits (171), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 104/215 (48%), Gaps = 34/215 (15%) Query: 5 TKIEK-IGEGTYGVVYKGRHKTTGQ---VVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 KIE+ IG G +G V +GR K G+ VA+K +++ E + E S++ + H Sbjct: 21 VKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQ-RRDFLSEASIMGQFDH 79 Query: 61 PNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 PNI+ L+ V+ + + ++ EF+ + L +L + GQ+ LV L I G+ + Sbjct: 80 PNIIRLEGVVTKSRPVMILTEFMENCALDSFL-RLNDGQFTVIQLV-GMLRGIAAGMKYL 137 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLAR-------------AFG--IPIRVYTHEV 164 +HRDL +N+L++ K++DFGL+R + G IPIR E Sbjct: 138 SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEA 197 Query: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT 199 + YR ++++ D+WS G + E+ + Sbjct: 198 IA--YR---------KFTSASDVWSYGIVMWEVMS 221 >4YFF-A nrPDB Length = 311 Score = 70.5 bits (171), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 56/212 (26%), Positives = 104/212 (49%), Gaps = 25/212 (11%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPSTAIREISLLKELRHPNIVSL 66 E IG G++G VYKGR + ++VA+K+ R + + RE+S+L +L HP ++ Sbjct: 48 EIIGSGSFGKVYKGRCRN--KIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQF 105 Query: 67 QDVLMQD-SRLYLIFEFLS--------MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 + D S+ ++ +++S + K+ LD + S L+ + + +G+ Sbjct: 106 VGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILD-------LQSKLIIAV--DVAKGME 156 Query: 118 FCH--SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEVVTLWYRSPEV 174 + H ++ ++HRDL N+L+ + G +ADFG +R + T + L + +PEV Sbjct: 157 YLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEV 216 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKK-PLFH 205 RY+ D++S E+ T + P H Sbjct: 217 FTQCTRYTIKADVFSYALCLWEILTGEIPFAH 248 >1K9A-A nrPDB Length = 450 Score = 70.5 bits (171), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 103/206 (50%), Gaps = 27/206 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 M++ ++ IG+G +G V G ++ G VA+K I+ ++ + + E S++ +LRH Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAF----LAEASVMTQLRH 245 Query: 61 PNIVSLQDVLMQD-SRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 N+V L V++++ LY++ E+++ L YL S L+K L + + + + Sbjct: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL-DVCEAMEY 304 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG-------IPIRVYTHEVVTLWYRS 171 +HRDL +N+L+ + K++DFGL + +P++ + + Sbjct: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK----------WTA 354 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAEL 197 PE L ++ST D+WS G + E+ Sbjct: 355 PEALR-EKKFSTKSDVWSFGILLWEI 379 >1BYG-A nrPDB Length = 278 Score = 70.5 bits (171), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 101/206 (49%), Gaps = 27/206 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 M++ ++ IG+G +G V G ++ G VA+K I+ + + E S++ +LRH Sbjct: 20 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK----NDATAQAFLAEASVMTQLRH 73 Query: 61 PNIVSLQDVLMQD-SRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 N+V L V++++ LY++ E+++ L YL S L+K L + + + + Sbjct: 74 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL-DVCEAMEY 132 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG-------IPIRVYTHEVVTLWYRS 171 +HRDL +N+L+ + K++DFGL + +P++ + + Sbjct: 133 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK----------WTA 182 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAEL 197 PE L ++ST D+WS G + E+ Sbjct: 183 PEALR-EKKFSTKSDVWSFGILLWEI 207 >1AD5-A nrPDB Length = 438 Score = 70.5 bits (171), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 63/230 (27%), Positives = 106/230 (46%), Gaps = 28/230 (12%) Query: 8 EKIGEGTYGVVYKGRHK--TTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVS 65 +K+G G +G V+ + T V MK + E + E +++K L+H +V Sbjct: 188 KKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE------AFLAEANVMKTLQHDKLVK 241 Query: 66 LQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVK--SYLYQILQGIVFCHSRR 123 L V+ ++ +Y+I EF++ LD + + L K + QI +G+ F R Sbjct: 242 LHAVVTKEP-IYIITEFMAKG--SLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRN 298 Query: 124 VLHRDLKPQNLLIDDKGTIKLADFGLARAFG-IPIRVYTHEVVTLWYRSPEVL-LGSARY 181 +HRDL+ N+L+ K+ADFGLAR PI+ + +PE + GS + Sbjct: 299 YIHRDLRAANILVSASLVCKIADFGLARVGAKFPIK----------WTAPEAINFGS--F 346 Query: 182 STPVDIWSIGTIFAELATKKPL-FHGDSEIDQLFRIFRALGTPNNEVWPE 230 + D+WS G + E+ T + + G S + + + R P E PE Sbjct: 347 TIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPE 396 >2OU7-A nrPDB Length = 335 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 66/244 (27%), Positives = 99/244 (40%), Gaps = 44/244 (18%) Query: 51 EISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLS----MDLKKYLDSI--PPGQYMDSSL 104 EIS+ + L H ++V + ++++ E ++L K ++ P +Y Sbjct: 91 EISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARY----- 145 Query: 105 VKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV 164 YL QI+ G + H RV+HRDLK NL +++ +K+ DFGLA Sbjct: 146 ---YLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLC 202 Query: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPN 224 T Y +PEV L +S VD+WSIG I L KP F + RI Sbjct: 203 GTPNYIAPEV-LSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRI-------- 253 Query: 225 NEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNH 284 KN + S+ H+ + L+ KML DP R + LN Sbjct: 254 ------------KKNEY------SIPKHINPV---AASLIQKMLQTDPTARPTINELLND 292 Query: 285 PYFN 288 +F Sbjct: 293 EFFT 296 >4J52-A nrPDB Length = 293 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 66/244 (27%), Positives = 99/244 (40%), Gaps = 44/244 (18%) Query: 51 EISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLS----MDLKKYLDSI--PPGQYMDSSL 104 EIS+ + L H ++V + ++++ E ++L K ++ P +Y Sbjct: 64 EISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARY----- 118 Query: 105 VKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV 164 YL QI+ G + H RV+HRDLK NL +++ +K+ DFGLA Sbjct: 119 ---YLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLC 175 Query: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPN 224 T Y +PEV L +S VD+WSIG I L KP F + RI Sbjct: 176 GTPNYIAPEV-LSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRI-------- 226 Query: 225 NEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNH 284 KN + S+ H+ + L+ KML DP R + LN Sbjct: 227 ------------KKNEY------SIPKHINPV---AASLIQKMLQTDPTARPTINELLND 265 Query: 285 PYFN 288 +F Sbjct: 266 EFFT 269 >5HLW-A nrPDB Length = 299 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 54/210 (25%), Positives = 103/210 (49%), Gaps = 29/210 (13%) Query: 8 EKIGEGTYGVVYKGR------HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E IG G +G VY G K V ++ +I + G S + E ++K+ HP Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRI----TDIGEVSQFLTEGIIMKDFSHP 81 Query: 62 NIVSLQDVLM--QDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 N++SL + + + S L ++ DL+ ++ + + + + Q+ +G+ + Sbjct: 82 NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLI--GFGLQVAKGMKYL 139 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL---- 175 S++ +HRDL +N ++D+K T+K+ADFGLAR ++ E ++ ++ L Sbjct: 140 ASKKFVHRDLAARNCMLDEKFTVKVADFGLAR------DMHDKEYYSVHNKTGAKLPVKW 193 Query: 176 -----LGSARYSTPVDIWSIGTIFAELATK 200 L + +++T D+WS G + EL T+ Sbjct: 194 MALESLQTQKFTTKSDVWSFGVLLWELMTR 223 >1U59-A nrPDB Length = 287 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 52/193 (26%), Positives = 94/193 (48%), Gaps = 9/193 (4%) Query: 9 KIGEGTYGVVYKGRHKT-TGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 ++G G +G V +G ++ Q+ K+ + E+ +RE ++ +L +P IV L Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 76 Query: 68 DVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 V Q L L+ E L K+L + + + S V L+Q+ G+ + + +H Sbjct: 77 GVC-QAEALMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 133 Query: 127 RDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLW---YRSPEVLLGSARYST 183 RDL +N+L+ ++ K++DFGL++A G YT W + +PE + ++S+ Sbjct: 134 RDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC-INFRKFSS 192 Query: 184 PVDIWSIGTIFAE 196 D+WS G E Sbjct: 193 RSDVWSYGVTMWE 205 >6BSD-A nrPDB Length = 876 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 59/225 (26%), Positives = 106/225 (47%), Gaps = 37/225 (16%) Query: 8 EKIGEGTYGVVYKGR----------------HKTTGQVVAMKKIRLESEEEGVPSTAIRE 51 EK+GEG +G V+ K +VA+K +R ++ + + ++E Sbjct: 577 EKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR-NDFLKE 635 Query: 52 ISLLKELRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYL------DSIPPGQYMDSSL 104 + ++ L+ PNI+ L V +QD L +I +++ + DL ++L D G D Sbjct: 636 VKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQA 695 Query: 105 VK----SY------LYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF- 153 + SY QI G+ + + +HRDL +N L+ + TIK+ADFG++R Sbjct: 696 AQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLY 755 Query: 154 -GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL 197 G RV V+ + + + E +L +++T D+W+ G E+ Sbjct: 756 AGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEV 799 >4IDT-A nrPDB Length = 356 Score = 69.7 bits (169), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 63/217 (29%), Positives = 98/217 (45%), Gaps = 30/217 (13%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 ++G G++G V++ K TG A+KK+RLE E+ L P IV L Sbjct: 81 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEV-------FRAEELMACAGLTSPRIVPLYG 133 Query: 69 VLMQDSRLYLIFEFLSM----DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 124 + + + + E L L K +P D +L YL Q L+G+ + HSRR+ Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLVKEQGCLP----EDRALY--YLGQALEGLEYLHSRRI 187 Query: 125 LHRDLKPQNLLIDDKGT-IKLADFGLARAF---GIPIRVYTHEVV--TLWYRSPEVLLGS 178 LH D+K N+L+ G+ L DFG A G+ + T + + T + +PEV+LG Sbjct: 188 LHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGR 247 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFR 215 + VD+WS + + +G Q FR Sbjct: 248 S-CDAKVDVWSSCCMMLH------MLNGCHPWTQFFR 277 >5GNK-A nrPDB Length = 297 Score = 69.7 bits (169), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 103/208 (49%), Gaps = 20/208 (9%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVV----AMKKIRLESEEEGVPSTAIREISLLKEL 58 ++ KI+ +G G +G VYKG G+ V A+K++R E+ + E ++ + Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASV 78 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMD-----LKKYLDSIPPGQYMDSSLVKSYLYQIL 113 +P++ L + + S + LI + + ++++ D+I S + ++ QI Sbjct: 79 DNPHVCRLLGICLT-STVQLIMQLMPFGCLLDYVREHKDNI------GSQYLLNWCVQIA 131 Query: 114 QGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHE--VVTLWYRS 171 +G+ + RR++HRDL +N+L+ +K+ DFGLA+ G + Y E V + + + Sbjct: 132 KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMA 191 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELAT 199 E +L Y+ D+WS G EL T Sbjct: 192 LESILHRI-YTHQSDVWSYGVTVWELMT 218 >5U6C-A nrPDB Length = 315 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 54/214 (25%), Positives = 103/214 (48%), Gaps = 33/214 (15%) Query: 10 IGEGTYGVVYKGRHKT---TGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 +GEG +G V +G K T VA+K ++L++ + + E + +K+ HPN++ L Sbjct: 44 LGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVMRL 103 Query: 67 QDVLMQDS-----RLYLIFEFLSM-DLKKYL--DSIPPG-QYMDSSLVKSYLYQILQGIV 117 V ++ S + +I F+ DL YL + G +++ + ++ I G+ Sbjct: 104 LGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGME 163 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL-- 175 + +R LHRDL +N ++ D T+ +ADFGL++ ++Y+ + +YR + Sbjct: 164 YLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSK------KIYSGD----YYRQGRIAKM 213 Query: 176 ---------LGSARYSTPVDIWSIGTIFAELATK 200 L Y++ D+W+ G E+AT+ Sbjct: 214 PVKWIAIESLADRVYTSKSDVWAFGVTMWEIATR 247 >2R2P-A nrPDB Length = 295 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 61/249 (24%), Positives = 122/249 (48%), Gaps = 18/249 (7%) Query: 10 IGEGTYGVVYKGRHKTTGQ---VVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 IG G +G V GR K G+ VA+K +++ E+ + E S++ + HPNI+ L Sbjct: 30 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQ-RRDFLGEASIMGQFDHPNIIHL 88 Query: 67 QDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 125 + V+ + + ++ E++ + L +L GQ+ LV L I G+ + + Sbjct: 89 EGVVTKSKPVMIVTEYMENGSLDTFLKK-NDGQFTVIQLV-GMLRGISAGMKYLSDMGYV 146 Query: 126 HRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHE--VVTLWYRSPEVLLGSARYS 182 HRDL +N+LI+ K++DFGL+R P YT + + + +PE + +++ Sbjct: 147 HRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEA-IAFRKFT 205 Query: 183 TPVDIWSIGTIFAELAT--KKPLFHGDSE-----IDQLFRIFRALGTPNNEVWPEVESLQ 235 + D+WS G + E+ + ++P + ++ +++ +R+ + P ++ Q Sbjct: 206 SASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQ 265 Query: 236 DYKNTFPKW 244 +N+ PK+ Sbjct: 266 KERNSRPKF 274 >4LQP-A nrPDB Length = 508 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 52/155 (33%), Positives = 80/155 (51%), Gaps = 7/155 (4%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESE--EEGVPSTAIREISLLKELR 59 ED+ ++ IG+G +G V + K TG++ AMK + L+SE ++ + E +L Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTL-LKSEMYKKDQLAHVKAERDVLAGSD 160 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 P +VSL LYLI EFL DL + + Q + + Y+ + + I Sbjct: 161 SPWVVSLYYSFQDAQYLYLIMEFLPGGDL---MTMLIRWQLFTEDVTRFYMAECILAIET 217 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF 153 H +HR +KP N+LID +G IKL+DFGL+ F Sbjct: 218 IHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGF 252 >3OMV-A nrPDB Length = 307 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 58/223 (26%), Positives = 108/223 (48%), Gaps = 14/223 (6%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR-EISLLKELRHPNIVSLQ 67 +IG G++G VYKG+ V +K + E+ A R E+++L++ RH NI+ Sbjct: 43 RIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQ----FQAFRNEVAVLRKTRHVNILLFM 98 Query: 68 DVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHR 127 + +D+ + L K+L + ++ L+ Q QG+ + H++ ++HR Sbjct: 99 GYMTKDNLAIVTQWCEGSSLYKHLH-VQETKFQMFQLI-DIARQTAQGMDYLHAKNIIHR 156 Query: 128 DLKPQNLLIDDKGTIKLADFGLARA---FGIPIRVYTHEVVTLWYRSPEV--LLGSARYS 182 D+K N+ + + T+K+ DFGLA + +V LW +PEV + + +S Sbjct: 157 DMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWM-APEVIRMQDNNPFS 215 Query: 183 TPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTPN 224 D++S G + EL T + P H ++ +F + R +P+ Sbjct: 216 FQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPD 258 >3LZB-A nrPDB Length = 327 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 103/208 (49%), Gaps = 20/208 (9%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVV----AMKKIRLESEEEGVPSTAIREISLLKEL 58 ++ KI+ +G G +G VYKG G+ V A+K++R E+ + E ++ + Sbjct: 16 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASV 74 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMD-----LKKYLDSIPPGQYMDSSLVKSYLYQIL 113 +P++ L + + S + LI + + ++++ D+I S + ++ QI Sbjct: 75 DNPHVCRLLGICLT-STVQLITQLMPFGCLLDYVREHKDNI------GSQYLLNWCVQIA 127 Query: 114 QGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHE--VVTLWYRS 171 +G+ + RR++HRDL +N+L+ +K+ DFGLA+ G + Y E V + + + Sbjct: 128 KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMA 187 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELAT 199 E +L Y+ D+WS G EL T Sbjct: 188 LESILHRI-YTHQSDVWSYGVTVWELMT 214 >5U6B-A nrPDB Length = 307 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 51/214 (23%), Positives = 98/214 (45%), Gaps = 33/214 (15%) Query: 10 IGEGTYGVVYKGRHKTTGQV--VAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 +GEG +G V +G+ + VA+K +++ + E +KE HPN++ L Sbjct: 31 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLI 90 Query: 68 DVLMQDSRL------YLIFEFLSM-DLKKYLDSIPPGQ---YMDSSLVKSYLYQILQGIV 117 V Q S +I F+ DL +L G Y+ + ++ ++ I G+ Sbjct: 91 GVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGME 150 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL-- 175 + ++R +HRDL +N ++++ ++ +ADFGL++ ++Y + +YR + Sbjct: 151 YLSTKRFIHRDLAARNCMLNENMSVCVADFGLSK------KIYNGD----YYRQGRIAKM 200 Query: 176 ---------LGSARYSTPVDIWSIGTIFAELATK 200 L Y++ D+WS G E+AT+ Sbjct: 201 PVKWIAIESLADRVYTSKSDVWSFGVTMWEIATR 234 >2QKW-B nrPDB Length = 321 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 57/196 (29%), Positives = 98/196 (50%), Gaps = 8/196 (4%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 IG G +G VYKG + G VA+K+ ES + EI L RHP++VSL Sbjct: 47 IGHGVFGKVYKGVLRD-GAKVALKRRTPESSQG--IEEFETEIETLSFCRHPHLVSLIGF 103 Query: 70 LMQDSRLYLIFEFL-SMDLKKYL-DSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHR 127 + + + LI++++ + +LK++L S P M +G+ + H+R ++HR Sbjct: 104 CDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAIIHR 163 Query: 128 DLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV--TLWYRSPEVLLGSARYSTPV 185 D+K N+L+D+ K+ DFG+++ + + VV TL Y PE + R + Sbjct: 164 DVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFI-KGRLTEKS 222 Query: 186 DIWSIGTIFAELATKK 201 D++S G + E+ + Sbjct: 223 DVYSFGVVLFEVLCAR 238 >2HK5-A nrPDB Length = 270 Score = 68.6 bits (166), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 64/232 (27%), Positives = 107/232 (46%), Gaps = 22/232 (9%) Query: 8 EKIGEGTYGVVYKGRHK--TTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVS 65 +K+G G +G V+ + T V MK + E + E +++K L+H +V Sbjct: 21 KKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE------AFLAEANVMKTLQHDKLVK 74 Query: 66 LQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVK--SYLYQILQGIVFCHSRR 123 L V+ ++ +Y+I EF++ LD + + L K + QI +G+ F R Sbjct: 75 LHAVVTKEP-IYIITEFMAKG--SLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRN 131 Query: 124 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHE---VVTLWYRSPEVL-LGSA 179 +HRDL+ N+L+ K+ADFGLAR I YT + + +PE + GS Sbjct: 132 YIHRDLRAANILVSASLVCKIADFGLARV--IEDNEYTAREGAKFPIKWTAPEAINFGS- 188 Query: 180 RYSTPVDIWSIGTIFAELATKKPL-FHGDSEIDQLFRIFRALGTPNNEVWPE 230 ++ D+WS G + E+ T + + G S + + + R P E PE Sbjct: 189 -FTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPE 239 >4F9B-A nrPDB Length = 361 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 84/347 (24%), Positives = 144/347 (41%), Gaps = 73/347 (21%) Query: 6 KIE-KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIV 64 KIE KIGEGT+ VY + QV +KI L+ +P++ I + EL+ + Sbjct: 24 KIEDKIGEGTFSSVYLATAQL--QVGPEEKIALK---HLIPTS--HPIRIAAELQCLTVA 76 Query: 65 SLQDVLMQDSRLY-----LIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 QD +M + ++ ++ + +LD + + + V+ Y+ + + + Sbjct: 77 GGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQE---VREYMLNLFKALKRI 133 Query: 120 HSRRVLHRDLKPQNLLIDDK-GTIKLADFGLARAF-----------------------GI 155 H ++HRD+KP N L + + L DFGLA+ Sbjct: 134 HQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKC 193 Query: 156 PIRVYTHEVV-----TLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKK-PLFHGDSE 209 I + + V T +R+PEVL +T +D+WS G IF L + + P + + Sbjct: 194 SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD 253 Query: 210 IDQLFRIFRALGT--------------------PNNEVWPEVESLQDYKNTFPKWKPGSL 249 + L +I G+ P ++ E L+ ++ PK + Sbjct: 254 LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLT-SDI 312 Query: 250 ASHVKNLD------ENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 H NL+ + DLL K+L +PA RI+ + AL HP+F D+ Sbjct: 313 QGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDM 359 >3CJF-A nrPDB Length = 309 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 66/273 (24%), Positives = 121/273 (44%), Gaps = 29/273 (10%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR-------HPN 62 +G G +G V + + + + ++ +EG + R +L+ EL+ H N Sbjct: 35 LGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHR--ALMSELKILIHIGHHLN 92 Query: 63 IVSLQDVLMQ-DSRLYLIFEFLSM-DLKKYLDS-----IPPGQ----YMDSSLVKSYLYQ 111 +V+L + L +I EF +L YL S +P ++ + Y +Q Sbjct: 93 VVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQ 152 Query: 112 ILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLAR-AFGIPIRVYTHEV-VTLWY 169 + +G+ F SR+ +HRDL +N+L+ +K +K+ DFGLAR + P V + + L + Sbjct: 153 VAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKW 212 Query: 170 RSPEVLLGSARYSTPVDIWSIGTIFAEL----ATKKPLFHGDSEIDQLFRIFRALGTPNN 225 +PE + Y+ D+WS G + E+ A+ P D E + + + P+ Sbjct: 213 MAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDY 271 Query: 226 EVWPEVESLQDYKNTFPKWKP--GSLASHVKNL 256 +++ D + P +P L H+ NL Sbjct: 272 TTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNL 304 >1JPA-A nrPDB Length = 312 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 70/268 (26%), Positives = 123/268 (45%), Gaps = 45/268 (16%) Query: 6 KIEK-IGEGTYGVVYKGRHKTTGQ---VVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 KIE+ IG G +G V G K G+ VA+K ++ E + E S++ + HP Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLK-SGYTEKQRRDFLSEASIMGQFDHP 94 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSI---PPGQYMDSSLVKSYLYQILQGIVF 118 N++ L+ V+ + + + +I EF+ LDS GQ+ LV L I G+ + Sbjct: 95 NVIHLEGVVTKSTPVMIITEFME---NGSLDSFLRQNDGQFTVIQLV-GMLRGIAAGMKY 150 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLAR-------------AFG--IPIRVYTHE 163 +HRDL +N+L++ K++DFGL+R A G IPIR E Sbjct: 151 LADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPE 210 Query: 164 VVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT--KKPLFHGDSE-----IDQLFRI 216 + YR ++++ D+WS G + E+ + ++P + ++ I+Q +R+ Sbjct: 211 AIQ--YR---------KFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRL 259 Query: 217 FRALGTPNNEVWPEVESLQDYKNTFPKW 244 + P+ ++ Q +N PK+ Sbjct: 260 PPPMDCPSALHQLMLDCWQKDRNHRPKF 287 >3BBT-B nrPDB Length = 328 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 53/214 (24%), Positives = 101/214 (47%), Gaps = 38/214 (17%) Query: 6 KIEKIGEGTYGVVYKGRHKTTGQVVAMK-KIRLESEEEGVPSTA--IREISLLKELRHPN 62 +++ +G G +G VYKG G+ V + I++ +E G + + E ++ + HP+ Sbjct: 19 RVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPH 78 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMD-----LKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 +V L V + + + L+ + + + ++ D+I S L+ ++ QI +G++ Sbjct: 79 LVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNI------GSQLLLNWCVQIAKGMM 131 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF------------GIPIRVYTHEVV 165 + RR++HRDL +N+L+ +K+ DFGLAR +PI+ E + Sbjct: 132 YLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECI 191 Query: 166 TLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT 199 YR +++ D+WS G EL T Sbjct: 192 H--YR---------KFTHQSDVWSYGVTIWELMT 214 >4XLV-A nrPDB Length = 328 Score = 67.4 bits (163), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 50/215 (23%), Positives = 106/215 (49%), Gaps = 21/215 (9%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIRE-------ISL 54 E T + ++G+G++G+VY+G + + A ++ +++ E S ++RE S+ Sbjct: 39 EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNE---SASLRERIEFLNEASV 95 Query: 55 LKELRHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQIL 113 +K ++V L V+ + ++ E ++ DLK YL S+ P + L +++ Sbjct: 96 MKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMI 155 Query: 114 Q-------GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP--IRVYTHEV 164 Q G+ + ++++ +HRDL +N ++ T+K+ DFG+ R R + Sbjct: 156 QMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGL 215 Query: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT 199 + + + +PE L ++T D+WS G + E+ + Sbjct: 216 LPVRWMAPESLKDGV-FTTSSDMWSFGVVLWEITS 249 >4P5Q-A nrPDB Length = 361 Score = 67.0 bits (162), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 62/254 (24%), Positives = 123/254 (48%), Gaps = 26/254 (10%) Query: 10 IGEGTYGVVYKGRHKTTGQ---VVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 +G G +G V GR K + VA+K +++ E+ + E S++ + HPNI+ L Sbjct: 41 VGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQ-RRDFLGEASIMGQFDHPNIIRL 99 Query: 67 QDVLMQDSRLYLIFEFL---SMD--LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 + V+ + + ++ E++ S+D L+K+ Q+ LV L I G+ + Sbjct: 100 EGVVTKSKPVMIVTEYMENGSLDSFLRKH-----DAQFTVIQLV-GMLRGIASGMKYLSD 153 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHE--VVTLWYRSPEVLLGS 178 +HRDL +N+LI+ K++DFGL+R P YT + + + SPE + Sbjct: 154 MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEA-IAY 212 Query: 179 ARYSTPVDIWSIGTIFAELAT--KKPLFHGDSE-----IDQLFRIFRALGTPNNEVWPEV 231 ++++ D+WS G + E+ + ++P + ++ +D+ +R+ + P + Sbjct: 213 RKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLML 272 Query: 232 ESLQDYKNTFPKWK 245 + Q +N PK++ Sbjct: 273 DCWQKDRNNRPKFE 286 >2OZO-A nrPDB Length = 613 Score = 67.0 bits (162), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 51/193 (26%), Positives = 94/193 (48%), Gaps = 9/193 (4%) Query: 9 KIGEGTYGVVYKGRHKT-TGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 ++G G +G V +G ++ Q+ K+ + E+ +RE ++ +L +P IV L Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402 Query: 68 DVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 V Q L L+ E L K+L + + + S V L+Q+ G+ + + +H Sbjct: 403 GVC-QAEALMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVH 459 Query: 127 RDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLW---YRSPEVLLGSARYST 183 R+L +N+L+ ++ K++DFGL++A G YT W + +PE + ++S+ Sbjct: 460 RNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC-INFRKFSS 518 Query: 184 PVDIWSIGTIFAE 196 D+WS G E Sbjct: 519 RSDVWSYGVTMWE 531 >3KUL-B nrPDB Length = 325 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 60/232 (25%), Positives = 108/232 (46%), Gaps = 17/232 (7%) Query: 7 IEKI-GEGTYGVVYKGRHKTTGQV---VAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 IEKI G G G V GR + GQ VA+K ++ E + E S++ + HPN Sbjct: 53 IEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTER-QRRDFLSEASIMGQFDHPN 111 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 I+ L+ V+ + ++ E++ GQ+ LV L + G+ + Sbjct: 112 IIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLV-GMLRGVGAGMRYLSDL 170 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHE--VVTLWYRSPEVLLGSA 179 +HRDL +N+L+D K++DFGL+R P YT + + + +PE + Sbjct: 171 GYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRT 230 Query: 180 RYSTPVDIWSIGTIFAELAT--KKPLFHGD-----SEIDQLFRIFRALGTPN 224 +S+ D+WS G + E+ ++P ++ S +++ +R+ +G P+ Sbjct: 231 -FSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPH 281 >2Y6O-A nrPDB Length = 291 Score = 66.2 bits (160), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/202 (27%), Positives = 102/202 (50%), Gaps = 12/202 (5%) Query: 6 KIEK-IGEGTYGVVYKGRHKTTGQ---VVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 KIEK IG G +G V GR K G+ VA+K ++ ++ + E S++ + HP Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQ-RRDFLSEASIMGQFDHP 75 Query: 62 NIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 NI+ L+ V+ + + +I E++ + L +L G++ LV L I G+ + Sbjct: 76 NIIHLEGVVTKCKPVMIITEYMENGSLDAFLRK-NDGRFTVIQLV-GMLRGIGSGMKYLS 133 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHE--VVTLWYRSPEVLLG 177 +HRDL +N+L++ K++DFG++R P YT + + + +PE + Sbjct: 134 DMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEA-IA 192 Query: 178 SARYSTPVDIWSIGTIFAELAT 199 ++++ D+WS G + E+ + Sbjct: 193 YRKFTSASDVWSYGIVMWEVMS 214 >4PDO-A nrPDB Length = 299 Score = 66.2 bits (160), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 56/204 (27%), Positives = 105/204 (51%), Gaps = 14/204 (6%) Query: 5 TKIEKIGEGTYGVVYKGRHKTTGQV----VAMKKIRLE-SEEEGVPSTAIREISLLKELR 59 T+ + IG G +G VYKG KT+ VA+K ++ +E++ V + E ++ + Sbjct: 37 TRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRV--DFLGEAGIMGQFS 94 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 H NI+ L+ V+ + + +I E++ + L K+L G++ LV L I G+ + Sbjct: 95 HHNIIRLEGVISKYKPMMIITEYMENGALDKFLRE-KDGEFSVLQLV-GMLRGIAAGMKY 152 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHE--VVTLWYRSPEVL 175 + +HRDL +N+L++ K++DFGL+R P YT + + + +PE Sbjct: 153 LANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEA- 211 Query: 176 LGSARYSTPVDIWSIGTIFAELAT 199 + ++++ D+WS G + E+ T Sbjct: 212 ISYRKFTSASDVWSFGIVMWEVMT 235 >5KMM-A nrPDB Length = 329 Score = 66.2 bits (160), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 101/220 (45%), Gaps = 27/220 (12%) Query: 9 KIGEGTYGVVYKGRH-----KTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 ++GEG +G V+ + +VA+K ++ SE RE LL L+H +I Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASES--ARQDFQREAELLTMLQHQHI 99 Query: 64 VSLQDVLMQDSRLYLIFEFLSM-DLKKYLDS-------------IPPGQYMDSSLVKSYL 109 V V + L ++FE++ DL ++L S + PG L+ + Sbjct: 100 VRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLL-AVA 158 Query: 110 YQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP--IRVYTHEVVTL 167 Q+ G+V+ +HRDL +N L+ +K+ DFG++R RV ++ + Sbjct: 159 SQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPI 218 Query: 168 WYRSPEVLLGSARYSTPVDIWSIGTIFAELAT--KKPLFH 205 + PE +L +++T D+WS G + E+ T K+P + Sbjct: 219 RWMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPWYQ 257 >3G2F-A nrPDB Length = 336 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 79/307 (25%), Positives = 135/307 (43%), Gaps = 47/307 (15%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 +E IG G YG VYKG + VA+K + + + I + L++ H NI Sbjct: 18 LELIGRGRYGAVYKG--SLDERPVAVKVFSFANRQNFINEKNIYRVPLME---HDNIARF 72 Query: 67 ---QDVLMQDSRL--YLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 + + D R+ L+ E+ + L KYL S+ ++ S + + + +G+ + H Sbjct: 73 IVGDERVTADGRMEYLLVMEYYPNGSLCKYL-SLHTSDWVSSCRLA---HSVTRGLAYLH 128 Query: 121 SR---------RVLHRDLKPQNLLIDDKGTIKLADFGLARAF--------GIPIRVYTHE 163 + + HRDL +N+L+ + GT ++DFGL+ G E Sbjct: 129 TELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISE 188 Query: 164 VVTLWYRSPEVLLGSARYS------TPVDIWSIGTIFAELATK-KPLFHGDSEIDQLFRI 216 V T+ Y +PEVL G+ VD++++G I+ E+ + LF G+S + Sbjct: 189 VGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAF 248 Query: 217 FRALGT-PNNEVWPEVESLQDYKNTFPK-WKPGSLASHVKNLDENGLDLLSKMLIYDPAK 274 +G P E + S + + FP+ WK SLA V++L E D + D Sbjct: 249 QTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLA--VRSLKETIEDCWDQ----DAEA 302 Query: 275 RISGKMA 281 R++ + A Sbjct: 303 RLTAQCA 309 >1FVR-A nrPDB Length = 327 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 51/206 (24%), Positives = 92/206 (44%), Gaps = 18/206 (8%) Query: 10 IGEGTYGVVYKGRHKTTG--QVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 IGEG +G V K R K G A+K+++ + ++ A L K HPNI++L Sbjct: 33 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLL 92 Query: 68 DVLMQDSRLYLIFEFLS----MDL---KKYLDSIPP-------GQYMDSSLVKSYLYQIL 113 LYL E+ +D + L++ P + S + + + Sbjct: 93 GACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVA 152 Query: 114 QGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 173 +G+ + ++ +HRDL +N+L+ + K+ADFGL+R + ++ + W Sbjct: 153 RGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIES 212 Query: 174 VLLGSARYSTPVDIWSIGTIFAELAT 199 L + Y+T D+WS G + E+ + Sbjct: 213 --LNYSVYTTNSDVWSYGVLLWEIVS 236 >3UIM-A nrPDB Length = 326 Score = 65.1 bits (157), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 52/212 (24%), Positives = 103/212 (48%), Gaps = 15/212 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++++ +G G +G VYKGR G +VA+K+++ E +G E+ ++ H Sbjct: 30 DNFSNKNILGRGGFGKVYKGRL-ADGTLVAVKRLK-EERTQGGELQFQTEVEMISMAVHR 87 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMD-----LKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 N++ L+ M + L++ +++ L++ +S PP +D + +G+ Sbjct: 88 NLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPP---LDWPKRQRIALGSARGL 144 Query: 117 VFCHSR---RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP-IRVYTHEVVTLWYRSP 172 + H +++HRD+K N+L+D++ + DFGLA+ V T T+ + +P Sbjct: 145 AYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAP 204 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLF 204 E L + + S D++ G + EL T + F Sbjct: 205 EY-LSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >4JLC-A nrPDB Length = 657 Score = 65.1 bits (157), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 59/208 (28%), Positives = 92/208 (44%), Gaps = 24/208 (11%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 +G+G V++GRHK TG + A+K S V +RE +LK+L H NIV L + Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 74 Query: 70 LMQDSRLY--LIFEFLSMDLKKYLDSIPPGQY-MDSSLVKSYLYQILQGIVFCHSRRVLH 126 + + + LI EF + P Y + S L ++ G+ ++H Sbjct: 75 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 134 Query: 127 RDLKPQNLLI----DDKGTIKLADFGLARAFGIPIRVYTHEVVTLW----YRSPEVLLGS 178 RD+KP N++ D + KL DFG AR + V+L+ Y P++ + Sbjct: 135 RDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-----EQFVSLYGTEEYLHPDMYERA 189 Query: 179 A-------RYSTPVDIWSIGTIFAELAT 199 +Y VD+WS+G F AT Sbjct: 190 VLRKDHQKKYGATVDLWSVGVTFYHAAT 217 >5C26-A nrPDB Length = 299 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 51/226 (22%), Positives = 109/226 (48%), Gaps = 16/226 (7%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKK--IRLESEEEGVPSTAIREISLLKELRHPNIVS 65 +++G G +G V KG ++ V + ++ E+ + + + E +++++L +P IV Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 66 LQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 124 + + +S + L+ E + L KYL +++ + ++Q+ G+ + Sbjct: 93 MIGICEAESWM-LVMEMAELGPLNKYLQQ---NRHVKDKNIIELVHQVSMGMKYLEESNF 148 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLW---YRSPEVLLGSARY 181 +HRDL +N+L+ + K++DFGL++A Y + W + +PE + ++ Sbjct: 149 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC-INYYKF 207 Query: 182 STPVDIWSIGTIFAELAT--KKPLFHG--DSEIDQLFRIFRALGTP 223 S+ D+WS G + E + +KP + G SE+ + +G P Sbjct: 208 SSKSDVWSFGVLMWEAFSYGQKP-YRGMKGSEVTAMLEKGERMGCP 252 >4EUU-A nrPDB Length = 319 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 59/208 (28%), Positives = 92/208 (44%), Gaps = 24/208 (11%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 +G+G V++GRHK TG + A+K S V +RE +LK+L H NIV L + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 75 Query: 70 LMQDSRLY--LIFEFLSMDLKKYLDSIPPGQY-MDSSLVKSYLYQILQGIVFCHSRRVLH 126 + + + LI EF + P Y + S L ++ G+ ++H Sbjct: 76 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 135 Query: 127 RDLKPQNLLI----DDKGTIKLADFGLARAFGIPIRVYTHEVVTLW----YRSPEVLLGS 178 R++KP N++ D + KL DFG AR + V+L+ Y P++ + Sbjct: 136 RNIKPGNIMRVIGEDGQSVYKLTDFGAAREL-----EDDEQFVSLYGTEEYLHPDMYERA 190 Query: 179 A-------RYSTPVDIWSIGTIFAELAT 199 +Y VD+WSIG F AT Sbjct: 191 VLRKDHQKKYGATVDLWSIGVTFYHAAT 218 >6NT9-A nrPDB Length = 742 Score = 64.7 bits (156), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 59/208 (28%), Positives = 92/208 (44%), Gaps = 24/208 (11%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 +G+G V++GRHK TG + A+K S V +RE +LK+L H NIV L + Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 73 Query: 70 LMQDSRLY--LIFEFLSMDLKKYLDSIPPGQY-MDSSLVKSYLYQILQGIVFCHSRRVLH 126 + + + LI EF + P Y + S L ++ G+ ++H Sbjct: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 133 Query: 127 RDLKPQNLLI----DDKGTIKLADFGLARAFGIPIRVYTHEVVTLW----YRSPEVLLGS 178 R++KP N++ D + KL DFG AR + V+L+ Y P++ + Sbjct: 134 RNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-----EQFVSLYGTEEYLHPDMYERA 188 Query: 179 A-------RYSTPVDIWSIGTIFAELAT 199 +Y VD+WSIG F AT Sbjct: 189 VLRKDHQKKYGATVDLWSIGVTFYHAAT 216 >4EUT-A nrPDB Length = 396 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 59/208 (28%), Positives = 92/208 (44%), Gaps = 24/208 (11%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 +G+G V++GRHK TG + A+K S V +RE +LK+L H NIV L + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 75 Query: 70 LMQDSRLY--LIFEFLSMDLKKYLDSIPPGQY-MDSSLVKSYLYQILQGIVFCHSRRVLH 126 + + + LI EF + P Y + S L ++ G+ ++H Sbjct: 76 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 135 Query: 127 RDLKPQNLLI----DDKGTIKLADFGLARAFGIPIRVYTHEVVTLW----YRSPEVLLGS 178 R++KP N++ D + KL DFG AR + V+L+ Y P++ + Sbjct: 136 RNIKPGNIMRVIGEDGQSVYKLTDFGAARELED-----DEQFVSLYGTEEYLHPDMYERA 190 Query: 179 A-------RYSTPVDIWSIGTIFAELAT 199 +Y VD+WSIG F AT Sbjct: 191 VLRKDHQKKYGATVDLWSIGVTFYHAAT 218 >4OW8-A nrPDB Length = 283 Score = 64.3 bits (155), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 96/220 (43%), Gaps = 34/220 (15%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR---EISLLKELRHPNIVSL 66 I G G V++ G+ VA+K L+SE P R E L HP I S+ Sbjct: 19 IATGGMGQVWEAVDNRLGRRVAVKV--LKSEFSSDPEFIERFRAEARTTAMLNHPGIASV 76 Query: 67 QD-----VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKS----------YLYQ 111 D + + YL+ E ++ G+ ++S L ++ L Q Sbjct: 77 HDYGESQMNGEGRTAYLVMELVN------------GEPLNSVLKRTGRLSLRHALDMLEQ 124 Query: 112 ILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEVVTLWYR 170 + + H+ ++HRD+KP N+LI G +K+ DFG+A+A P+ + T Y Sbjct: 125 TGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYI 184 Query: 171 SPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEI 210 +PE LG S D++S+G + E + K F GD + Sbjct: 185 APEQALGH-DASPASDVYSLGVVGYEAVSGKRPFAGDGAL 223 >6O8B-A nrPDB Length = 665 Score = 64.3 bits (155), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 59/203 (29%), Positives = 92/203 (45%), Gaps = 14/203 (6%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 +G+G V++GRHK TG + A+K S V +RE +LK+L H NIV L + Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 81 Query: 70 LMQDSRLY--LIFEFLSMDLKKYLDSIPPGQY-MDSSLVKSYLYQILQGIVFCHSRRVLH 126 + + + LI EF + P Y + S L ++ G+ ++H Sbjct: 82 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 141 Query: 127 RDLKPQNLLI----DDKGTIKLADFGLARAFGIP---IRVY-THEVV--TLWYRSPEVLL 176 R++KP N++ D + KL DFG AR + +Y T E + ++ R+ Sbjct: 142 RNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVLRKD 201 Query: 177 GSARYSTPVDIWSIGTIFAELAT 199 +Y VD+WSIG F AT Sbjct: 202 HQKKYGATVDLWSIGVTFYHAAT 224 >5FM2-A nrPDB Length = 355 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 60/230 (26%), Positives = 101/230 (43%), Gaps = 53/230 (23%) Query: 10 IGEGTYGVVYK-------GRHKTTGQVVAMKKIRLESEEEGVPSTA---IREISLLKELR 59 +GEG +G V K GR T V M K E PS + E ++LK++ Sbjct: 72 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK------ENASPSELRDLLSEFNVLKQVN 125 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDS---IPPG------------------ 97 HP+++ L QD L LI E+ L+ +L + PG Sbjct: 126 HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDE 185 Query: 98 QYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI 157 + + + S+ +QI QG+ + +++HRDL +N+L+ + +K++DFGL+R Sbjct: 186 RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRD----- 240 Query: 158 RVYTHEV--------VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT 199 VY + + + + + E L Y+T D+WS G + E+ T Sbjct: 241 -VYEEDSYVKRSQGRIPVKWMAIESLFDHI-YTTQSDVWSFGVLLWEIVT 288 >4LRM-A nrPDB Length = 334 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 57/215 (26%), Positives = 103/215 (47%), Gaps = 31/215 (14%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQ----VVAMKKIRLESEEEGVPSTAIREI------ 52 ++ KI+ +G G +G VYKG G+ VA+K++R E A +EI Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-----EATSPKANKEILDEAYV 74 Query: 53 -SLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMD-----LKKYLDSIPPGQYMDSSLVK 106 + + +P++ L + + S + LI + + ++++ D+I S + Sbjct: 75 MASVDNPGNPHVCRLLGICLT-STVQLITQLMPFGCLLDYVREHKDNI------GSQYLL 127 Query: 107 SYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHE--V 164 ++ QI +G+ + RR++HRDL +N+L+ +K+ DFGLA+ G + Y E Sbjct: 128 NWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGK 187 Query: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT 199 V + + + E +L Y+ D+WS G EL T Sbjct: 188 VPIKWMALESILHRI-YTHQSDVWSYGVTVWELMT 221 >3LLT-A nrPDB Length = 360 Score = 63.9 bits (154), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 86/338 (25%), Positives = 133/338 (39%), Gaps = 75/338 (22%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI--- 63 I K+G+GT+G V +H + A+K +R + +A E +LK++++ +I Sbjct: 40 IRKMGDGTFGRVLLCQHIDNKKYYAVKVVR---NIKKYTRSAKIEADILKKIQNDDINNN 96 Query: 64 --VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSL--VKSYLYQILQGIVFC 119 V M + LIFE L L + I Y + +K Y +IL+ + + Sbjct: 97 NIVKYHGKFMYYDHMCLIFEPLGPSL---YEIITRNNYNGFHIEDIKLYCIEILKALNYL 153 Query: 120 HSRRVLHRDLKPQNLLIDD------------------------KGT-IKLADFGLARAFG 154 + H DLKP+N+L+DD K T IKL DFG A Sbjct: 154 RKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCA---T 210 Query: 155 IPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLF 214 + + T YR+PEV+L + D+WS G + AEL T LF ++ L Sbjct: 211 FKSDYHGSIINTRQYRAPEVILNLG-WDVSSDMWSFGCVLAELYTGSLLFRTHEHMEHLA 269 Query: 215 ------------RIFRALGTPNNE---------VWPE----VESLQDYKNTFPKWKPGSL 249 ++ A T ++ WPE + S++ K P +K + Sbjct: 270 MMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYK---I 326 Query: 250 ASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 H E D L +L DP R S L H + Sbjct: 327 IKH-----ELFCDFLYSILQIDPTLRPSPAELLKHKFL 359 >2PMN-X nrPDB Length = 348 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 56/259 (21%), Positives = 108/259 (41%), Gaps = 39/259 (15%) Query: 51 EISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMD-----------LKKYLDSIPPGQY 99 E+ ++ ++++ ++ + ++ +Y+I+E++ D L K P Q Sbjct: 93 ELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCFIPIQ- 151 Query: 100 MDSSLVKSYLYQILQGIVFCHS-RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR 158 ++K + +L + H+ + + HRD+KP N+L+D G +KL+DFG + + + + Sbjct: 152 ----VIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESE-YMVDKK 206 Query: 159 VYTHEVVTLWYRSPEVLLGSARYS-TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIF 217 + T + PE + Y+ VDIWS+G + F + +LF Sbjct: 207 I-KGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELFNNI 265 Query: 218 RALGTP-----NNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDP 272 R N+ ++P N F L +D L L +P Sbjct: 266 RTKNIEYPLDRNHFLYPLTNKKSTCSNNF--------------LSNEDIDFLKLFLRKNP 311 Query: 273 AKRISGKMALNHPYFNDLD 291 A+RI+ + AL H + D + Sbjct: 312 AERITSEDALKHEWLADTN 330 >6B2Q-A nrPDB Length = 317 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 96/220 (43%), Gaps = 34/220 (15%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR---EISLLKELRHPNIVSL 66 I G G V++ G+ VA+K L+SE P R E L HP I S+ Sbjct: 40 IATGGMGQVWEAVDNRLGRRVAVKV--LKSEFSSDPEFIERFRAEARTTAMLNHPGIASV 97 Query: 67 QD-----VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKS----------YLYQ 111 D + + YL+ E ++ G+ ++S L ++ L Q Sbjct: 98 HDYGESQMNGEGRTAYLVMELVN------------GEPLNSVLKRTGRLSLRHALDMLEQ 145 Query: 112 ILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEVVTLWYR 170 + + H+ ++HRD+KP N+LI G +K+ DFG+A+A P+ + T Y Sbjct: 146 TGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYI 205 Query: 171 SPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEI 210 +PE LG S D++S+G + E + K F GD + Sbjct: 206 APEQALGH-DASPASDVYSLGVVGYEAVSGKRPFAGDGAL 244 >4X3F-A nrPDB Length = 337 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 96/220 (43%), Gaps = 34/220 (15%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR---EISLLKELRHPNIVSL 66 I G G V++ G+ VA+K L+SE P R E L HP I S+ Sbjct: 20 IATGGMGQVWEAVDNRLGRRVAVKV--LKSEFSSDPEFIERFRAEARTTAMLNHPGIASV 77 Query: 67 QD-----VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKS----------YLYQ 111 D + + YL+ E ++ G+ ++S L ++ L Q Sbjct: 78 HDYGESQMNGEGRTAYLVMELVN------------GEPLNSVLKRTGRLSLRHALDMLEQ 125 Query: 112 ILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEVVTLWYR 170 + + H+ ++HRD+KP N+LI G +K+ DFG+A+A P+ + T Y Sbjct: 126 TGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYI 185 Query: 171 SPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEI 210 +PE LG S D++S+G + E + K F GD + Sbjct: 186 APEQALGH-DASPASDVYSLGVVGYEAVSGKRPFAGDGAL 224 >2Y4I-B nrPDB Length = 319 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 98/209 (46%), Gaps = 22/209 (10%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 E IG+G +G VY GR VA++ I +E + E RE+ ++ RH N+V Sbjct: 39 ELIGKGRFGQVYHGRWHGE---VAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFM 95 Query: 68 DVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQ--YMDSSLVKSYLYQILQGIVFCHSRRVL 125 M L +I S+ + L S+ +D + + +I++G+ + H++ +L Sbjct: 96 GACMSPPHLAII---TSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGIL 152 Query: 126 HRDLKPQNLLIDDKGTIKLADFGLARAFGI--------PIRVYTHEVVTLWYR-----SP 172 H+DLK +N+ D+ G + + DFGL G+ +R+ + L SP Sbjct: 153 HKDLKSKNVFYDN-GKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSP 211 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELATKK 201 + +S D++++GTI+ EL ++ Sbjct: 212 DTEEDKLPFSKHSDVFALGTIWYELHARE 240 >4FL3-A nrPDB Length = 635 Score = 63.5 bits (153), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 51/226 (22%), Positives = 109/226 (48%), Gaps = 16/226 (7%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKK--IRLESEEEGVPSTAIREISLLKELRHPNIVS 65 +++G G +G V KG ++ V + ++ E+ + + + E +++++L +P IV Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 434 Query: 66 LQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 124 + + +S + L+ E + L KYL +++ + ++Q+ G+ + Sbjct: 435 MIGICEAESWM-LVMEMAELGPLNKYLQQ---NRHVKDKNIIELVHQVSMGMKYLEESNF 490 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLW---YRSPEVLLGSARY 181 +HRDL +N+L+ + K++DFGL++A Y + W + +PE + ++ Sbjct: 491 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC-INYYKF 549 Query: 182 STPVDIWSIGTIFAELAT--KKPLFHG--DSEIDQLFRIFRALGTP 223 S+ D+WS G + E + +KP + G SE+ + +G P Sbjct: 550 SSKSDVWSFGVLMWEAFSYGQKP-YRGMKGSEVTAMLEKGERMGCP 594 >5LPV-A nrPDB Length = 296 Score = 63.5 bits (153), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 59/201 (29%), Positives = 95/201 (47%), Gaps = 15/201 (7%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 IG G +G VYK K G VA+KK+ S + A E+ + +++H N+V L Sbjct: 25 IGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDREFMA--EMETIGKIKHRNLVPLLGY 81 Query: 70 LMQDSRLYLIFEFLSM-DLKKYL-DSIPPGQYMDSSLVKSYLYQILQGIVFCH---SRRV 124 L++EF+ L+ L D G ++ S + +G+ F H S + Sbjct: 82 CKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHI 141 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL----LGSAR 180 +HRD+K N+L+D+ +++DFG+AR + TH V+ +P + S R Sbjct: 142 IHRDMKSSNVLLDENLEARVSDFGMARLMSA---MDTHLSVSTLAGTPGYVPPEYYQSFR 198 Query: 181 YSTPVDIWSIGTIFAELATKK 201 ST D++S G + EL T K Sbjct: 199 CSTKGDVYSYGVVLLELLTGK 219 >3KA0-A nrPDB Length = 320 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 75/299 (25%), Positives = 126/299 (42%), Gaps = 45/299 (15%) Query: 1 MEDYTKIEKI-GEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISL-LKEL 58 ++DY ++ G G G V + +K T + A+K + + P A RE+ L + Sbjct: 14 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPK-ARREVELHWRAS 66 Query: 59 RHPNIVSLQDVL--MQDSRLYLIFEFLSMDLKKYLDSIPP--GQYMDSSLVKSYLYQILQ 114 + P+IV + DV + R L+ +D + I Q + I + Sbjct: 67 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 126 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRS 171 I + HS + HRD+KP+NLL K +KL DFG A+ T T +Y + Sbjct: 127 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTEPCYTPYYVA 185 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PEV LG +Y D+WS+G I L P F+ + + + P + Sbjct: 186 PEV-LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL---------------AISPGM 229 Query: 232 ES---LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 ++ + Y+ P+W ++ VK L N +L +P +R++ +NHP+ Sbjct: 230 KTRIRMGQYEFPNPEW--SEVSEEVKMLIRN-------LLKTEPTQRMTITEFMNHPWI 279 >4H1J-A nrPDB Length = 293 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 97/211 (45%), Gaps = 14/211 (6%) Query: 2 EDYTKIEKIGEGTYGVVYKG---RHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL 58 ED +GEG +G VY+G HK VA+K + + + + E ++K L Sbjct: 24 EDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNL 82 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 HP+IV L ++ ++ ++ + +L YL+ + + Y QI + + + Sbjct: 83 DHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLER--NKNSLKVLTLVLYSLQICKAMAY 140 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVT---LWYRSPEVL 175 S +HRD+ +N+L+ +KL DFGL+R I Y VT + + SPE Sbjct: 141 LESINCVHRDIAVRNILVASPECVKLGDFGLSRY--IEDEDYYKASVTRLPIKWMSPES- 197 Query: 176 LGSARYSTPVDIWSIGTIFAELAT--KKPLF 204 + R++T D+W E+ + K+P F Sbjct: 198 INFRRFTTASDVWMFAVCMWEILSFGKQPFF 228 >5LPZ-A nrPDB Length = 332 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/201 (29%), Positives = 95/201 (47%), Gaps = 15/201 (7%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 IG G +G VYK K G VA+KK+ S + A E+ + +++H N+V L Sbjct: 25 IGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDREFMA--EMETIGKIKHRNLVPLLGY 81 Query: 70 LMQDSRLYLIFEFLSM-DLKKYL-DSIPPGQYMDSSLVKSYLYQILQGIVFCH---SRRV 124 L++EF+ L+ L D G ++ S + +G+ F H S + Sbjct: 82 CKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHI 141 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL----LGSAR 180 +HRD+K N+L+D+ +++DFG+AR + TH V+ +P + S R Sbjct: 142 IHRDMKSSNVLLDENLEARVSDFGMARLMSA---MDTHLSVSTLAGTPGYVPPEYYQSFR 198 Query: 181 YSTPVDIWSIGTIFAELATKK 201 ST D++S G + EL T K Sbjct: 199 CSTKGDVYSYGVVLLELLTGK 219 >1NY3-A nrPDB Length = 400 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 75/299 (25%), Positives = 126/299 (42%), Gaps = 45/299 (15%) Query: 1 MEDYTKIEKI-GEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISL-LKEL 58 ++DY ++ G G G V + +K T + A+K + + P A RE+ L + Sbjct: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPK-ARREVELHWRAS 112 Query: 59 RHPNIVSLQDVL--MQDSRLYLIFEFLSMDLKKYLDSIPP--GQYMDSSLVKSYLYQILQ 114 + P+IV + DV + R L+ +D + I Q + I + Sbjct: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 172 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRS 171 I + HS + HRD+KP+NLL K +KL DFG A+ T T +Y + Sbjct: 173 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVA 231 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PEV LG +Y D+WS+G I L P F+ + + + P + Sbjct: 232 PEV-LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL---------------AISPGM 275 Query: 232 ES---LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 ++ + Y+ P+W ++ VK L N +L +P +R++ +NHP+ Sbjct: 276 KTRIRMGQYEFPNPEW--SEVSEEVKMLIRN-------LLKTEPTQRMTITEFMNHPWI 325 >4M66-A nrPDB Length = 325 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 64/217 (29%), Positives = 105/217 (48%), Gaps = 29/217 (13%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR-EISLLKELRH 60 E+ K+E +G+G +GVV++ H+T VA+K + S I E+ + LR+ Sbjct: 20 EELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVN---------SKKISWEVKAMVNLRN 70 Query: 61 PNIVSLQDV---LMQD--SRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 N++ L V L D S L+ F+ + L L P + L+ L +++ Sbjct: 71 ENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRPW---PLLCRLLQEVVL 127 Query: 115 GIVFCHSRR--VLHRDLKPQNLLIDDKGTIKLADFGLA------RAFGIPIRVYTHEVVT 166 G+ + HS +LHRDLKP N+L+D + KLADFGL+ ++ T Sbjct: 128 GMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGT 187 Query: 167 LWYRSPEVLLG-SARYSTPVDIWSIGT-IFAELATKK 201 L Y PE+L + + S D++S G ++A LA ++ Sbjct: 188 LAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGRE 224 >3HNG-A nrPDB Length = 360 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 33/93 (35%), Positives = 54/93 (58%), Gaps = 3/93 (3%) Query: 107 SYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLAR-AFGIPIRVYTHEV- 164 SY +Q+ +G+ F SR+ +HRDL +N+L+ + +K+ DFGLAR + P V + Sbjct: 203 SYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTR 262 Query: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL 197 + L + +PE + YST D+WS G + E+ Sbjct: 263 LPLKWMAPESIFDKI-YSTKSDVWSYGVLLWEI 294 >2OZA-A nrPDB Length = 356 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 75/299 (25%), Positives = 126/299 (42%), Gaps = 45/299 (15%) Query: 1 MEDYTKIEKI-GEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISL-LKEL 58 ++DY ++ G G G V + +K T + A+K + + P A RE+ L + Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPK-ARREVELHWRAS 68 Query: 59 RHPNIVSLQDVL--MQDSRLYLIFEFLSMDLKKYLDSIPP--GQYMDSSLVKSYLYQILQ 114 + P+IV + DV + R L+ +D + I Q + I + Sbjct: 69 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 128 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRS 171 I + HS + HRD+KP+NLL K +KL DFG A+ T T +Y + Sbjct: 129 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVA 187 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PEV LG +Y D+WS+G I L P F+ + + + P + Sbjct: 188 PEV-LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL---------------AISPGM 231 Query: 232 ES---LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 ++ + Y+ P+W ++ VK L N +L +P +R++ +NHP+ Sbjct: 232 KTRIRMGQYEFPNPEW--SEVSEEVKMLIRN-------LLKTEPTQRMTITEFMNHPWI 281 >3MDY-A nrPDB Length = 337 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 79/298 (26%), Positives = 134/298 (44%), Gaps = 46/298 (15%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 +++IG+G YG V+ G+ + G+ VA+K E T I + L+ RH NI+ Sbjct: 42 VKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRETEIYQTVLM---RHENILGF 96 Query: 67 QDVLMQDS----RLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 ++ + +LYLI ++ + L YL S +D+ + Y + G+ H+ Sbjct: 97 IAADIKGTGSWTQLYLITDYHENGSLYDYLKSTT----LDAKSMLKLAYSSVSGLCHLHT 152 Query: 122 R--------RVLHRDLKPQNLLIDDKGTIKLADFGLARAF-------GIPIRVYTHEVVT 166 + HRDLK +N+L+ GT +AD GLA F IP V T Sbjct: 153 EIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNT---RVGT 209 Query: 167 LWYRSPEVL---LGSARYSTPV--DIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG 221 Y PEVL L + + + D++S G I E+A ++ + G E QL Sbjct: 210 KRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVA-RRCVSGGIVEEYQLPYHDLVPS 268 Query: 222 TPNNEVWPEVESLQDYKNTFP-KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG 278 P+ E E+ ++ + +FP +W S + L + G L+++ ++PA R++ Sbjct: 269 DPSYEDMREIVCIKKLRPSFPNRW------SSDECLRQMG-KLMTECWAHNPASRLTA 319 >2BUJ-A nrPDB Length = 317 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 95/213 (44%), Gaps = 29/213 (13%) Query: 4 YTKIEKIGEGTYGVV--YKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 Y I+K+GEG + V +G H G A+K+I +++ A RE + + HP Sbjct: 31 YLFIQKLGEGGFSYVDLVEGLHD--GHFYALKRILCHEQQD--REEAQREADMHRLFNHP 86 Query: 62 NIVSLQDVLMQD----SRLYLIFEF-----LSMDLKKYLDSIPPGQYMDSSLVKSYLYQI 112 NI+ L +++ +L+ F L ++++ D G ++ + L I Sbjct: 87 NILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDK---GNFLTEDQILWLLLGI 143 Query: 113 LQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI---------RVYTHE 163 +G+ H++ HRDLKP N+L+ D+G L D G I + + + + Sbjct: 144 CRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQ 203 Query: 164 VVTLWYRSPEVLLGSARY--STPVDIWSIGTIF 194 T+ YR+PE+ + D+WS+G + Sbjct: 204 RCTISYRAPELFSVQSHCVIDERTDVWSLGCVL 236 >5HI2-A nrPDB Length = 283 Score = 61.6 bits (148), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 55/227 (24%), Positives = 102/227 (44%), Gaps = 42/227 (18%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIV--- 64 ++IG G++G VYKG+ V + +L++ + E+ +L++ RH NI+ Sbjct: 26 QRIGSGSFGTVYKGKWHGDVAVKMLTPQQLQAFKN--------EVGVLRKTRHVNILLFM 77 Query: 65 --------SLQDVLMQDSRLY--LIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 ++ + S LY L ++KK +D Q + Sbjct: 78 GYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLID---------------IARQTAR 122 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVT---LWYRS 171 G+ + H++ ++HRDLK N+ + + T+K+ DFGLA + E ++ LW + Sbjct: 123 GMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM-A 181 Query: 172 PEV--LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRI 216 PEV + S YS D+++ G + EL T + + + DQ+ + Sbjct: 182 PEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEM 228 >5WNO-A nrPDB Length = 330 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 47/201 (23%), Positives = 90/201 (44%), Gaps = 16/201 (7%) Query: 8 EKIGEGTYGVVYKG-----RHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 +K+G G +G V+ G R K VA+K + + + + E + + LRH N Sbjct: 28 KKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQ---TDEMLEEATNMFRLRHDN 84 Query: 63 IVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 ++ + M D L ++ + + +L+ +L ++ Y YQI G+ + Sbjct: 85 LLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVL--YCYQIASGMQYLEK 142 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF---GIPIRVYTHEVVTLWYRSPEVLLGS 178 +RV+HRDL +N+L+ +++ DFGL++ I + + +V W + Sbjct: 143 QRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIE--IFSK 200 Query: 179 ARYSTPVDIWSIGTIFAELAT 199 Y+ D+W+ G E+ T Sbjct: 201 HCYTHASDVWAFGVTCWEIIT 221 >5HIE-A nrPDB Length = 302 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 54/223 (24%), Positives = 107/223 (47%), Gaps = 17/223 (7%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 ++IG G++G VYKG+ V + +L++ + E+ +L++ RH NI+ Sbjct: 42 QRIGSGSFGTVYKGKWHGDVAVKMLTPQQLQAFKN--------EVGVLRKTRHVNILLFM 93 Query: 68 DVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHR 127 + +L ++ ++ + I ++ L+ Q QG+ + H++ ++HR Sbjct: 94 GYSTK-PQLAIVTQWCEGSSLYHHLHIIETKFEMIKLI-DIARQTAQGMDYLHAKSIIHR 151 Query: 128 DLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVT---LWYRSPEVLLGSAR--YS 182 DLK N+ + + T+K+ DFGLA + E ++ LW +PEV+ + YS Sbjct: 152 DLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWM-APEVIRMQDKNPYS 210 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQ-LFRIFRALGTPN 224 D+++ G + EL T + + + DQ +F + R +P+ Sbjct: 211 FQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPD 253 >2WTK-B nrPDB Length = 373 Score = 61.2 bits (147), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 101/210 (48%), Gaps = 20/210 (9%) Query: 4 YTKIEKIGEGTYGV--VYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 Y + IG+G + V R+K TG+ V +++I LE+ + + E+ + K HP Sbjct: 11 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 70 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMD--SSLVKSYLYQ-ILQGIVF 118 NIV + + D+ L+++ F++ K L +MD + L +Y+ Q +L+ + + Sbjct: 71 NIVPYRATFIADNELWVVTSFMAYGSAKDLICT---HFMDGMNELAIAYILQGVLKALDY 127 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLAR-----AFGIPIRVY----THEVVTLWY 169 H +HR +K ++LI G + L+ GL + G RV + V L + Sbjct: 128 IHHMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVKVLPW 185 Query: 170 RSPEVLLGSAR-YSTPVDIWSIGTIFAELA 198 SPEVL + + Y DI+S+G ELA Sbjct: 186 LSPEVLQQNLQGYDAKSDIYSVGITACELA 215 >3QD2-B nrPDB Length = 332 Score = 60.8 bits (146), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 38/99 (38%), Positives = 52/99 (52%), Gaps = 13/99 (13%) Query: 111 QILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG---------IPIRVY- 160 QI + + F HS+ ++HRDLKP N+ +K+ DFGL A P+ Y Sbjct: 172 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYA 231 Query: 161 --THEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL 197 T +V T Y SPE + G+ YS VDI+S+G I EL Sbjct: 232 THTGQVGTKLYMSPEQIHGN-NYSHKVDIFSLGLILFEL 269 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 22/64 (34%), Positives = 37/64 (57%), Gaps = 1/64 (1%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 + D+ I+ +G G +GVV++ ++K A+K+IRL + E +RE+ L +L H Sbjct: 5 LTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAR-EKVMREVKALAKLEH 63 Query: 61 PNIV 64 P IV Sbjct: 64 PGIV 67 >5IKW-A nrPDB Length = 310 Score = 60.8 bits (146), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 63/215 (29%), Positives = 104/215 (48%), Gaps = 33/215 (15%) Query: 8 EKIGEGTYGVVYKGRHKTTGQV-VAMKKIRLESEEEGVPSTAIREISLLKELR-HPNIVS 65 E + EG + V+ R T G + A+K++ + + + + REI+++KEL H NIV Sbjct: 20 ESLAEGGFSTVFLVR--THGGIRCALKRMYVNNMPD--LNVCKREITIMKELSGHKNIVG 75 Query: 66 LQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLY-QILQGIVFCHSRR- 123 D + +S ++E L L +Y + M+ L + ++LQ +FC + Sbjct: 76 YLDCAV-NSISDNVWEVLI--LMEYCRAGQVVNQMNKKLQTGFTEPEVLQ--IFCDTCEA 130 Query: 124 ----------VLHRDLKPQNLLIDDKGTIKLADFGLA-RAFGIP----IRVYTHEV---V 165 ++HRDLK +N+L++D G L DFG A F P + V E+ Sbjct: 131 VARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYT 190 Query: 166 TLWYRSPEV--LLGSARYSTPVDIWSIGTIFAELA 198 TL YR+PE+ L G +T DIW++G + +L Sbjct: 191 TLSYRAPEMINLYGGKPITTKADIWALGCLLYKLC 225 >4Y83-A nrPDB Length = 332 Score = 60.5 bits (145), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 53/194 (27%), Positives = 90/194 (46%), Gaps = 13/194 (6%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 I G +G VY + T + +A K I ++ + PS ++ + RH NI L Sbjct: 81 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFK---PS----DVEIQACFRHENIAELYGA 133 Query: 70 LMQDSRLYLIFEF-LSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 ++ ++L E + + L+S P + + V + +L+G+ F HS++V+H D Sbjct: 134 VLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKH---VLKGLDFLHSKKVIHHD 190 Query: 129 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIW 188 +KP N++ + L DFGL+ + T Y SPEV+L +ST DI+ Sbjct: 191 IKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRG-HSTKADIY 248 Query: 189 SIGTIFAELATKKP 202 S+G + T P Sbjct: 249 SLGATLIHMQTGTP 262 >5TE0-A nrPDB Length = 347 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 61/221 (27%), Positives = 102/221 (46%), Gaps = 44/221 (19%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR-HPNIVSL 66 E + EG + +V+ R + G A+K++ + +E + REI ++++L H NIV Sbjct: 25 EVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHD--LQVCKREIQIMRDLSGHKNIVGY 81 Query: 67 QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQY---MDSSLVKSYL-YQILQGIVFCHSR 122 D + + ++E L + +D GQ M+ L + ++LQ +FC + Sbjct: 82 IDSSINNVSSGDVWEVLIL-----MDFCRGGQVVNLMNQRLQTGFTENEVLQ--IFCDTC 134 Query: 123 R-----------VLHRDLKPQNLLIDDKGTIKLADFGLA-RAFGIP-----------IRV 159 ++HRDLK +N+L+ D+G L DFG A F P I+ Sbjct: 135 EAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKK 194 Query: 160 YTHEVVTLWYRSPEV--LLGSARYSTPVDIWSIGTIFAELA 198 YT TL YR+PE+ L +T DIW++G + +L Sbjct: 195 YT----TLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLC 231 >5X02-A nrPDB Length = 347 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/216 (25%), Positives = 91/216 (42%), Gaps = 29/216 (13%) Query: 10 IGEGTYGVVYK----GRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHPNIV 64 +G G +G V G KT + K+ E + + E+ ++ +L H NIV Sbjct: 56 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIV 115 Query: 65 SLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPG------QYMDSSLVK----------- 106 +L +YLIFE+ DL YL S +Y + ++ Sbjct: 116 NLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTFE 175 Query: 107 ---SYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--VYT 161 + YQ+ +G+ F + +HRDL +N+L+ +K+ DFGLAR V Sbjct: 176 DLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRG 235 Query: 162 HEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL 197 + + + + +PE L Y+ D+WS G + E+ Sbjct: 236 NARLPVKWMAPESLF-EGIYTIKSDVWSYGILLWEI 270 >4XUF-A nrPDB Length = 297 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/216 (25%), Positives = 91/216 (42%), Gaps = 29/216 (13%) Query: 10 IGEGTYGVVYK----GRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHPNIV 64 +G G +G V G KT + K+ E + + E+ ++ +L H NIV Sbjct: 17 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIV 76 Query: 65 SLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPG------QYMDSSLVK----------- 106 +L +YLIFE+ DL YL S +Y + ++ Sbjct: 77 NLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTFE 136 Query: 107 ---SYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--VYT 161 + YQ+ +G+ F + +HRDL +N+L+ +K+ DFGLAR V Sbjct: 137 DLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRG 196 Query: 162 HEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL 197 + + + + +PE L Y+ D+WS G + E+ Sbjct: 197 NARLPVKWMAPESLF-EGIYTIKSDVWSYGILLWEI 231 >6GQK-A nrPDB Length = 328 Score = 58.9 bits (141), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 90/213 (42%), Gaps = 30/213 (14%) Query: 10 IGEGTYGVVY----KGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHPNIV 64 +G G +G V +G K+ + K+ S + E+ +L L H NIV Sbjct: 49 LGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHENIV 108 Query: 65 SLQDVLMQDSRLYLIFEFLSM-DLKKYL----DSIPPGQYMDSSLVKSYL---------Y 110 +L +I E+ DL +L D P + L K +L Y Sbjct: 109 NLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSY 168 Query: 111 QILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV------ 164 Q+ +G+ F S+ +HRDL +N+L+ K+ DFGLAR I+ ++ V Sbjct: 169 QVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLAR----DIKNDSNYVDKGNAR 224 Query: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL 197 + + + +PE + S Y+ D+WS G EL Sbjct: 225 LPVKWMAPESIFNSV-YTFESDVWSYGIFLWEL 256 >5WNL-A nrPDB Length = 342 Score = 58.5 bits (140), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 61/219 (27%), Positives = 105/219 (47%), Gaps = 34/219 (15%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAI--RE-ISLLKELR 59 ++ EK+G G +G VYK RH +A+K PS + RE + LL+E + Sbjct: 21 EFAGWEKVGSGGFGQVYKVRHVHWKTWLAIK---------CSPSLHVDDRERMELLEEAK 71 Query: 60 HPNIVSLQDVL----MQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 + + +L + + L+ E++ L+K L S P + L +++ Sbjct: 72 KMEMAKFRYILPVYGICQEPVGLVMEYMETGSLEKLLASEP----LPWDLRFRIVHETAV 127 Query: 115 GIVF--CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV------T 166 G+ F C S +LH +LKP N+L+D +K++DFGLA+ G+ ++H++ T Sbjct: 128 GMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGM---SHSHDLSMDGLFGT 184 Query: 167 LWYRSPEVLLGSAR-YSTPVDIWSIG-TIFAELATKKPL 203 + Y PE + +R + T D++S I+ L KKP Sbjct: 185 IAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPF 223 >3ZBF-A nrPDB Length = 322 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 97/209 (46%), Gaps = 22/209 (10%) Query: 10 IGEGTYGVVYKGRHK-----TTGQV-VAMKKIRLES-EEEGVPSTAIREISLLKELRHPN 62 +G G +G VY+G +G++ VA+K ++ S ++E + ++E L+ + HPN Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKI--EFLKEAHLMSKFNHPN 98 Query: 63 IVSLQDVLMQDSRLYLIFEFL-SMDLKKYLD----SIPPGQYMDSSLVKSYLYQILQGIV 117 I+ V + + Y+I E + DL YL + G + + I +G V Sbjct: 99 ILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCV 158 Query: 118 FCHSRRVLHRDLKPQNLLIDDKG-----TIKLADFGLARAF--GIPIRVYTHEVVTLWYR 170 + +HRDL +N L+ K +K+ DFGLAR R ++ + + Sbjct: 159 YLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWM 218 Query: 171 SPEVLLGSARYSTPVDIWSIGTIFAELAT 199 +PE L+ ++T D+WS G + E+ T Sbjct: 219 APESLMDGI-FTTQSDVWSFGILIWEILT 246 >3PP0-A nrPDB Length = 338 Score = 58.2 bits (139), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 53/202 (26%), Positives = 92/202 (45%), Gaps = 14/202 (6%) Query: 6 KIEKIGEGTYGVVYKGRHKTTGQ----VVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 K++ +G G +G VYKG G+ VA+K +R E+ + E ++ + P Sbjct: 21 KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLR-ENTSPKANKEILDEAYVMAGVGSP 79 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQ-YMDSSLVKSYLYQILQGIVFCH 120 + L + + S + L+ + M LD + + + S + ++ QI +G+ + Sbjct: 80 YVSRLLGICLT-STVQLVTQL--MPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLE 136 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHE---VVTLWYRSPEVLLG 177 R++HRDL +N+L+ +K+ DFGLAR I Y + V W +L Sbjct: 137 DVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESIL-- 194 Query: 178 SARYSTPVDIWSIGTIFAELAT 199 R++ D+WS G EL T Sbjct: 195 RRRFTHQSDVWSYGVTVWELMT 216 >4OTD-A nrPDB Length = 341 Score = 57.8 bits (138), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 101/215 (46%), Gaps = 12/215 (5%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIR----LESEEEGVPSTAIREISLLK 56 +ED+ + +G G +G V + +G++ A+K ++ + +E R ++ + Sbjct: 11 LEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVT 70 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEF-LSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 HP +V+L + + E+ DL ++ S Y ++ G Sbjct: 71 SAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS----DVFSEPRAIFYSACVVLG 126 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLAR-AFGIPIRVYTHEVVTLWYRSPEV 174 + F H ++++RDLK NLL+D +G +K+ADFGL + G R T T + +PEV Sbjct: 127 LQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTF-CGTPEFLAPEV 185 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSE 209 L ++ Y+ VD W +G + E+ + F GD E Sbjct: 186 LTDTS-YTRAVDWWGLGVLLYEMLVGESPFPGDDE 219 >5GRN-A nrPDB Length = 356 Score = 57.8 bits (138), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 73/288 (25%), Positives = 120/288 (41%), Gaps = 46/288 (15%) Query: 10 IGEGTYGVVYKG------RHKTTGQV-VAMKKIRLESEEEGVPSTAIREISLLKELR-HP 61 +G G +G V +G R + +V V M K S E+ + E+ ++ L H Sbjct: 54 LGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEK---QALMSELKIMTHLGPHL 110 Query: 62 NIVSLQDVLMQDSRLYLIFE-----------------FLSMDLKKYLDSIPPGQYMDSSL 104 NIV+L + +Y+I E FLS K LDS D + Sbjct: 111 NIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNS 170 Query: 105 -------VKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI 157 + S+ YQ+ +G+ F S+ +HRDL +N+L+ +K+ DFGLAR + Sbjct: 171 EGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI-MHD 229 Query: 158 RVYTHEVVTLW---YRSPEVLLGSARYSTPVDIWSIGTIFAEL----ATKKPLFHGDSEI 210 Y + T + +PE + + Y+T D+WS G + E+ T P DS Sbjct: 230 SNYVSKGSTFLPVKWMAPESIFDNL-YTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTF 288 Query: 211 DQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPG--SLASHVKNL 256 + + P++ E + N+ P+ +P L+ V+NL Sbjct: 289 YNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENL 336 >4F0G-A nrPDB Length = 287 Score = 57.8 bits (138), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 54/210 (25%), Positives = 98/210 (46%), Gaps = 19/210 (9%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRL---ESEEEGVP--STAIREISLLKELRHPN 62 ++IG+G +G+V+KGR VVA+K + L E E E + RE+ ++ L HPN Sbjct: 25 KQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNLNHPN 84 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 IV L ++ R+ + F + LD P ++ S+ + I GI + ++ Sbjct: 85 IVKLYGLMHNPPRMVMEFVPCGDLYHRLLDKAHPIKW---SVKLRLMLDIALGIEYMQNQ 141 Query: 123 R--VLHRDLKPQNLL---IDDKGTI--KLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 ++HRDL+ N+ +D+ + K+ADFGL++ + + + + +PE + Sbjct: 142 NPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ---SVHSVSGLLGNFQWMAPETI 198 Query: 176 LGSAR-YSTPVDIWSIGTIFAELATKKPLF 204 Y+ D +S I + T + F Sbjct: 199 GAEEESYTEKADTYSFAMILYTILTGEGPF 228 >2H34-A nrPDB Length = 309 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 55/202 (27%), Positives = 91/202 (45%), Gaps = 9/202 (4%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAI-REISLLKELRHPNIVSLQD 68 +G G G VY+ ++VA+K + + V T + RE L+ P++V + D Sbjct: 42 VGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHVVPIHD 101 Query: 69 VLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHR 127 D +LY+ ++ +DL L P + + + QI + H+ HR Sbjct: 102 FGEIDGQLYVDMRLINGVDLAAMLRRQGP---LAPPRAVAIVRQIGSALDAAHAAGATHR 158 Query: 128 DLKPQNLLIDDKGTIKLADFGLARAFGIP-IRVYTHEVVTLWYRSPEVLLGS-ARYSTPV 185 D+KP+N+L+ L DFG+A A + + V TL+Y +PE S A Y Sbjct: 159 DVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHATYR--A 216 Query: 186 DIWSIGTIFAELATKKPLFHGD 207 DI+++ + E T P + GD Sbjct: 217 DIYALTCVLYECLTGSPPYQGD 238 >4CRS-A nrPDB Length = 341 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 101/219 (46%), Gaps = 20/219 (9%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIR----LESEEEGVPSTAIREISLLK 56 ++D+ + G +G V +K T ++ A+K ++ + +E R + Sbjct: 11 LQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVN 70 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEF-----LSMDLKKYLDSIPPGQYMDSSLVKSYLYQ 111 +RHP +V+L + + E+ L M + + S P + Y Sbjct: 71 SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVF--------YAAC 122 Query: 112 ILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLAR-AFGIPIRVYTHEVVTLWYR 170 ++ G+ + H ++++RDLK NLL+D +G +K+ADFGL + G R T T + Sbjct: 123 VVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTF-CGTPEFL 181 Query: 171 SPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSE 209 +PEVL ++ Y+ VD W +G + E+ + F GD E Sbjct: 182 APEVLTETS-YTRAVDWWGLGVLIYEMLVGESPFPGDDE 219 >3VHK-A nrPDB Length = 368 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 51/210 (24%), Positives = 89/210 (42%), Gaps = 37/210 (17%) Query: 83 LSMDLKKYLD-------------------------SIPPGQYMDSSLVK---SYLYQILQ 114 + +DLK+ LD P Y D ++ Y +Q+ + Sbjct: 152 IPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAK 211 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLAR-AFGIPIRVYTHEV-VTLWYRSP 172 G+ F SR+ +HRDL +N+L+ +K +K+ DFGLAR + P V + + L + +P Sbjct: 212 GMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAP 271 Query: 173 EVLLGSARYSTPVDIWSIGTIFAEL----ATKKPLFHGDSEIDQLFRIFRALGTPNNEVW 228 E + Y+ D+WS G + E+ A+ P D E + + + P+ Sbjct: 272 ETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTP 330 Query: 229 PEVESLQDYKNTFPKWKP--GSLASHVKNL 256 +++ D + P +P L H+ NL Sbjct: 331 EMYQTMLDCWHGEPSQRPTFSELVEHLGNL 360 >3KRL-A nrPDB Length = 335 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 52/209 (24%), Positives = 93/209 (44%), Gaps = 22/209 (10%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIR---LESEEEGVPSTAI-REISLLKEL-RHPNIV 64 +G G +G V + G+ A+ K+ L+S A+ E+ ++ L +H NIV Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 113 Query: 65 SLQDVLMQDSRLYLIFEFLSM-DLKKYLD-SIPPG------------QYMDSSLVKSYLY 110 +L + +I E+ DL +L PPG + + S + + Sbjct: 114 NLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSS 173 Query: 111 QILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--VYTHEVVTLW 168 Q+ QG+ F S+ +HRD+ +N+L+ + K+ DFGLAR V + + + Sbjct: 174 QVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVK 233 Query: 169 YRSPEVLLGSARYSTPVDIWSIGTIFAEL 197 + +PE + Y+ D+WS G + E+ Sbjct: 234 WMAPESIFDCV-YTVQSDVWSYGILLWEI 261 >3Q4U-A nrPDB Length = 301 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 62/225 (27%), Positives = 95/225 (42%), Gaps = 41/225 (18%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D T +E +G+G YG V++G + G+ VA+K E+ T + +L RH N Sbjct: 9 DITLLECVGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSWFRETELYNTVML---RHEN 63 Query: 63 IVSL--QDVLMQDS--RLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 I+ D+ + S +L+LI + M L YL +D+ + I G+ Sbjct: 64 ILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTT----LDTVSCLRIVLSIASGLA 119 Query: 118 FCHSR--------RVLHRDLKPQNLLIDDKGTIKLADFGLARA---------FGIPIRVY 160 H + HRDLK +N+L+ G +AD GLA G RV Sbjct: 120 HLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVG 179 Query: 161 THEVVTLWYRSPEVLLGSARYST-----PVDIWSIGTIFAELATK 200 T Y +PEVL + + VDIW+ G + E+A + Sbjct: 180 TKR-----YMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARR 219 >5VDK-A nrPDB Length = 297 Score = 55.1 bits (131), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 37/141 (26%), Positives = 71/141 (50%), Gaps = 3/141 (2%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RH 60 +++ ++EKIG G +G VYK + G V A+K+ E ++A+ E+ L H Sbjct: 15 KEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHH 74 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYL-DSIPPGQYMDSSLVKSYLYQILQGIVF 118 P++V +D + + E+ + L+ + ++ G + + +K L QI G+ + Sbjct: 75 PHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNY 134 Query: 119 CHSRRVLHRDLKPQNLLIDDK 139 H+ ++H D+KP N+ I K Sbjct: 135 IHNSSMVHLDIKPSNIFICHK 155 >3BEA-A nrPDB Length = 333 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 52/207 (25%), Positives = 93/207 (44%), Gaps = 20/207 (9%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIR---LESEEEGVPSTAI-REISLLKEL-RHPNIV 64 +G G +G V + G+ A+ K+ L+S A+ E+ ++ L +H NIV Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 113 Query: 65 SLQDVLMQDSRLYLIFEFLSM-DL-------KKYLDSIPPGQYMDSSLVKSYLY----QI 112 +L + +I E+ DL + L++ P +S+L L Q+ Sbjct: 114 NLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQV 173 Query: 113 LQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--VYTHEVVTLWYR 170 QG+ F S+ +HRD+ +N+L+ + K+ DFGLAR V + + + + Sbjct: 174 AQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWM 233 Query: 171 SPEVLLGSARYSTPVDIWSIGTIFAEL 197 +PE + Y+ D+WS G + E+ Sbjct: 234 APESIFDCV-YTVQSDVWSYGILLWEI 259 >3SOC-A nrPDB Length = 322 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 101/211 (47%), Gaps = 22/211 (10%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 +E G +G V+K + + VA+K ++ ++ E+ L ++H NI+ Sbjct: 29 LEVKARGRFGCVWKA--QLLNEYVAVKIFPIQDKQSWQNEY---EVYSLPGMKHENILQF 83 Query: 67 QDVLMQ----DSRLYLIFEF-----LSMDLKKYLDSIPPGQYMDSSLVK--SYLYQILQG 115 + D L+LI F LS LK + S ++ ++ + +YL++ + G Sbjct: 84 IGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPG 143 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTHEVVTLWYRSPE 173 + H + HRD+K +N+L+ + T +ADFGLA F G +V T Y +PE Sbjct: 144 LKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPE 203 Query: 174 VLLGSARYSTP----VDIWSIGTIFAELATK 200 VL G+ + +D++++G + ELA++ Sbjct: 204 VLEGAINFQRDAFLRIDMYAMGLVLWELASR 234 >4R7H-A nrPDB Length = 343 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 53/216 (24%), Positives = 96/216 (44%), Gaps = 29/216 (13%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIR---LESEEEGVPSTAI-REISLLKEL-RHPNIV 64 +G G +G V + G+ A+ K+ L+S A+ E+ ++ L +H NIV Sbjct: 58 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 117 Query: 65 SLQDVLMQDSRLYLIFEFLSM-DLKKYL---------DSIPPGQ-----------YMDSS 103 +L + +I E+ + DL +L S+ PGQ ++ Sbjct: 118 NLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELR 177 Query: 104 LVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--VYT 161 + + Q+ QG+ F S+ +HRD+ +N+L+ + K+ DFGLAR V Sbjct: 178 DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKG 237 Query: 162 HEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL 197 + + + + +PE + S Y+ D+WS G + E+ Sbjct: 238 NARLPVKWMAPESIFDSV-YTVQSDVWSYGILLWEI 272 >1PY5-A nrPDB Length = 326 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 57/212 (26%), Positives = 93/212 (43%), Gaps = 25/212 (11%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 E IG+G +G V++G+ + G+ VA+K E I + +L RH NI+ Sbjct: 35 ESIGKGRFGEVWRGKWR--GEEVAVKIFSSREERSWFREAEIYQTVML---RHENILGFI 89 Query: 68 DVLMQD----SRLYLIFEFLSMD-----LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 +D ++L+L+ ++ L +Y ++ G + S L + IV Sbjct: 90 AADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE-GMIKLALSTASGLAHLHMEIVG 148 Query: 119 CHSR-RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY----THEVVTLWYRSPE 173 + + HRDLK +N+L+ GT +AD GLA H V T Y +PE Sbjct: 149 TQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE 208 Query: 174 VLLGSARYS-----TPVDIWSIGTIFAELATK 200 VL S DI+++G +F E+A + Sbjct: 209 VLDDSINMKHFESFKRADIYAMGLVFWEIARR 240 >3AOX-A nrPDB Length = 344 Score = 53.9 bits (128), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 51/212 (24%), Positives = 95/212 (44%), Gaps = 19/212 (8%) Query: 2 EDYTKIEKIGEGTYGVVYKGR-----HKTTGQVVAMKKI-RLESEEEGVPSTAIREISLL 55 ++ T I +G G +G VY+G+ + + VA+K + + SE++ + + E ++ Sbjct: 47 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDEL--DFLMEALII 104 Query: 56 KELRHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 + H NIV V +Q +++ E ++ DLK +L P SSL L + + Sbjct: 105 SKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVAR 164 Query: 115 ----GIVFCHSRRVLHRDLKPQNLLIDDKG---TIKLADFGLARAF--GIPIRVYTHEVV 165 G + +HRD+ +N L+ G K+ DFG+AR R ++ Sbjct: 165 DIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAML 224 Query: 166 TLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL 197 + + PE + +++ D WS G + E+ Sbjct: 225 PVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEI 255 >3QUP-A nrPDB Length = 323 Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 51/214 (23%), Positives = 97/214 (45%), Gaps = 16/214 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQV---VAMKKIRLESEEEGVPSTAIREISLLKEL 58 + +T +G+G +G V + + K VA+K ++ + +RE + +KE Sbjct: 23 QQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEF 82 Query: 59 RHPNIVSLQDVLMQD---SRL---YLIFEFLSM-DLKKYLDSIPPGQY---MDSSLVKSY 108 HP++ L V ++ RL +I F+ DL +L + G+ + + + Sbjct: 83 DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRF 142 Query: 109 LYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTHEVVT 166 + I G+ + SR +HRDL +N ++ + T+ +ADFGL+R G R + Sbjct: 143 MVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLP 202 Query: 167 LWYRSPEVLLGSARYSTPVDIWSIGTIFAELATK 200 + + + E L Y+ D+W+ G E+ T+ Sbjct: 203 VKWLALES-LADNLYTVHSDVWAFGVTMWEIMTR 235 >2OGV-A nrPDB Length = 317 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 49/203 (24%), Positives = 91/203 (44%), Gaps = 16/203 (7%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIR---LESEEEGVPSTAI-REISLLKEL-RHPNIV 64 +G G +G V + G+ A+ K+ L+S A+ E+ ++ L +H NIV Sbjct: 46 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 105 Query: 65 SLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPP-------GQYMDSSLVKSYLYQILQGI 116 +L + +I E+ DL +L G+ ++ + + Q+ QG+ Sbjct: 106 NLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGM 165 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--VYTHEVVTLWYRSPEV 174 F S+ +HRD+ +N+L+ + K+ DFGLAR V + + + + +PE Sbjct: 166 AFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPES 225 Query: 175 LLGSARYSTPVDIWSIGTIFAEL 197 + Y+ D+WS G + E+ Sbjct: 226 IFDCV-YTVQSDVWSYGILLWEI 247 >5X1R-A nrPDB Length = 302 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 43/163 (26%), Positives = 68/163 (41%), Gaps = 20/163 (12%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKK--------------IRLESEEEGVPSTA----- 48 E IGEG +G+VY+ + +A+K+ I L E G A Sbjct: 27 EAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQAGLNSF 86 Query: 49 IREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSY 108 I+E LL HP ++ + ++ Y+ +F S K L + P + +D + ++ Sbjct: 87 IQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQP-EKIDEAWIRRL 145 Query: 109 LYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLAR 151 L + I H LHRD+ N+ I + L DFG AR Sbjct: 146 LPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSAR 188 >5X18-A nrPDB Length = 295 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 52/182 (28%), Positives = 81/182 (44%), Gaps = 17/182 (9%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH-PNIVSL 66 +KIGEG++GV+++G + G VA I+ E + P E K L PNI Sbjct: 13 KKIGEGSFGVLFEGTNMINGVPVA---IKFEPRKTEAPQLR-DEYKTYKILNGTPNIPYA 68 Query: 67 QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 + L+ + L L+ D G+ V Q++ I H+ +++ Sbjct: 69 YYFGQEGLHNILVIDLLGPSLEDLFDWC--GRKFSVKTVVQVAVQMITLIEDLHAHDLIY 126 Query: 127 RDLKPQNLLID-----DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 RD+KP N LI D I L DFG+A+ + P + H + YR + L G+ARY Sbjct: 127 RDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDP-KTKQH----IPYREKKSLSGTARY 181 Query: 182 ST 183 + Sbjct: 182 MS 183 >3G0E-A nrPDB Length = 336 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 11/97 (11%) Query: 107 SYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVT 166 S+ YQ+ +G+ F S+ +HRDL +N+L+ K+ DFGLAR I+ ++ VV Sbjct: 172 SFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLAR----DIKNDSNYVVK 227 Query: 167 ------LWYRSPEVLLGSARYSTPVDIWSIGTIFAEL 197 + + +PE + Y+ D+WS G EL Sbjct: 228 GNARLPVKWMAPESIFNCV-YTFESDVWSYGIFLWEL 263 >4Y12-A nrPDB Length = 375 Score = 50.4 bits (119), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 40/159 (25%), Positives = 78/159 (49%), Gaps = 18/159 (11%) Query: 54 LLKELRHPNIVSLQDVLMQDSR-----LYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKS 107 L E+ HP+IV + + + R Y++ E++ LK+ GQ + + + Sbjct: 171 FLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRS-----KGQKLPVAEAIA 225 Query: 108 YLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTL 167 YL +IL + + HS +++ DLKP+N+++ ++ +KL D G I + + T Sbjct: 226 YLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSR----INSFGYLYGTP 280 Query: 168 WYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHG 206 +++PE++ +T DI+++G A L P +G Sbjct: 281 GFQAPEIVRTGPTVAT--DIYTVGRTLAALTLDLPTRNG 317 >1CSN-A nrPDB Length = 298 Score = 50.4 bits (119), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 48/181 (26%), Positives = 80/181 (44%), Gaps = 21/181 (11%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPS--TAIREISLLKELRH-PNIVS 65 +IGEG++GV+++G + Q VA I+ E P R LL PN+ Sbjct: 17 RIGEGSFGVIFEGTNLLNNQQVA---IKFEPRRSDAPQLRDEYRTYKLLAGCTGIPNVYY 73 Query: 66 LQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 125 + + L+ + L L+ LD G+ V Q+L + H + ++ Sbjct: 74 FGQEGLHNV---LVIDLLGPSLEDLLDLC--GRKFSVKTVAMAAKQMLARVQSIHEKSLV 128 Query: 126 HRDLKPQNLLI-----DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 +RD+KP N LI + I + DFG+ + + P+ T + + YR + L G+AR Sbjct: 129 YRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPV---TKQHIP--YREKKNLSGTAR 183 Query: 181 Y 181 Y Sbjct: 184 Y 184 >5AR8-A nrPDB Length = 326 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 57/212 (26%), Positives = 97/212 (45%), Gaps = 23/212 (10%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIR-----LESEEEGVPSTAIREISLLKELRHPNIV 64 + G G V RH VA+K + L+SE + V +RE +L + R I+ Sbjct: 40 LSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDV----LREAEILHKARFSYIL 95 Query: 65 SLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSS--LVKSYLYQILQGIVFCHS 121 + + + L ++ E++ + L + L +Y D + L L++I G+ + H+ Sbjct: 96 PILGICNEPEFLGIVTEYMPNGSLNELLHR--KTEYPDVAWPLRFRILHEIALGVNYLHN 153 Query: 122 RR--VLHRDLKPQNLLIDDKGTIKLADFGLAR-----AFGIPIRVYTHEVVTLWYRSPEV 174 +LH DLK QN+L+D++ +K+ADFGL++ E T+ Y PE Sbjct: 154 MTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPEN 213 Query: 175 LLGS--ARYSTPVDIWSIGTIFAELATKKPLF 204 +R S DI+S I E+ ++K F Sbjct: 214 YEPGQKSRASIKHDIYSYAVITWEVLSRKQPF 245 >3LMG-A nrPDB Length = 344 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 50/202 (24%), Positives = 94/202 (46%), Gaps = 14/202 (6%) Query: 6 KIEKIGEGTYGVVYKGRHKTTGQV----VAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 K++ +G G +G V+KG G+ V +K I +S + + +++ L H Sbjct: 35 KLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAI-GSLDHA 93 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQ-YMDSSLVKSYLYQILQGIVFCH 120 +IV L L S L L+ ++L L LD + + + L+ ++ QI +G+ + Sbjct: 94 HIVRLLG-LCPGSSLQLVTQYLP--LGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLE 150 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--VYTHEVVTL-WYRSPEVLLG 177 ++HR+L +N+L+ +++ADFG+A + +Y+ + W + G Sbjct: 151 EHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFG 210 Query: 178 SARYSTPVDIWSIGTIFAELAT 199 +Y+ D+WS G EL T Sbjct: 211 --KYTHQSDVWSYGVTVWELMT 230 >4TN6-A nrPDB Length = 318 Score = 49.7 bits (117), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 49/180 (27%), Positives = 87/180 (48%), Gaps = 15/180 (8%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP-NIVSL 66 KIG G++G +Y G G+ VA I+LE + P I E + K ++ I ++ Sbjct: 13 RKIGSGSFGDIYLGTDIAAGEEVA---IKLECVKTKHPQLHI-ESKIYKMMQGGVGIPTI 68 Query: 67 QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 + + ++ E L L+ + + + L+ + Q++ I + HS+ +H Sbjct: 69 RWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLAD--QMISRIEYIHSKNFIH 126 Query: 127 RDLKPQNLL--IDDKGT-IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYST 183 RD+KP N L + KG + + DFGLA+ + R + H + YR + L G+ARY++ Sbjct: 127 RDVKPDNFLMGLGKKGNLVYIIDFGLAKKYR-DARTHQH----IPYRENKNLTGTARYAS 181 >2PZI-A nrPDB Length = 681 Score = 49.7 bits (117), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 40/159 (25%), Positives = 78/159 (49%), Gaps = 18/159 (11%) Query: 54 LLKELRHPNIVSLQDVLMQDSRL-----YLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKS 107 L E+ HP+IV + + + R Y++ E++ LK+ GQ + + + Sbjct: 132 FLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRS-----KGQKLPVAEAIA 186 Query: 108 YLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTL 167 YL +IL + + HS +++ DLKP+N+++ ++ +KL D G I + + T Sbjct: 187 YLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSR----INSFGYLYGTP 241 Query: 168 WYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHG 206 +++PE++ +T DI+++G A L P +G Sbjct: 242 GFQAPEIVRTGPTVAT--DIYTVGRTLAALTLDLPTRNG 278 >4NFN-A nrPDB Length = 309 Score = 49.7 bits (117), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 44/153 (28%), Positives = 77/153 (50%), Gaps = 12/153 (7%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR-EISLLKELRHPNIVS 65 ++KIG G +G +Y+ T + VA+K +ES ++ P ++ E+++LK+L+ + V Sbjct: 26 LKKIGGGGFGEIYEAMDLLTRENVALK---VESAQQ--PKQVLKMEVAVLKKLQGKDHVC 80 Query: 66 LQDVLMQDSRL-YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 124 ++ + Y++ + +L S P G + S+ ++ QIL+ I HS Sbjct: 81 RFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLR-LGKQILESIEAIHSVGF 139 Query: 125 LHRDLKPQNL----LIDDKGTIKLADFGLARAF 153 LHRD+KP N L + DFGLAR + Sbjct: 140 LHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY 172 >4BTK-A nrPDB Length = 337 Score = 49.7 bits (117), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 44/153 (28%), Positives = 77/153 (50%), Gaps = 12/153 (7%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR-EISLLKELRHPNIVS 65 ++KIG G +G +Y+ T + VA+K +ES ++ P ++ E+++LK+L+ + V Sbjct: 61 LKKIGGGGFGEIYEAMDLLTRENVALK---VESAQQ--PKQVLKMEVAVLKKLQGKDHVC 115 Query: 66 LQDVLMQDSRL-YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 124 ++ + Y++ + +L S P G + S+ ++ QIL+ I HS Sbjct: 116 RFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLR-LGKQILESIEAIHSVGF 174 Query: 125 LHRDLKPQNL----LIDDKGTIKLADFGLARAF 153 LHRD+KP N L + DFGLAR + Sbjct: 175 LHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY 207 >5CEK-A nrPDB Length = 263 Score = 49.7 bits (117), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 52/245 (21%), Positives = 92/245 (37%), Gaps = 57/245 (23%) Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 H NI + +V++ +++ Y+ FE D+ Y+ S + + QI+ + C Sbjct: 60 HSNITGIVEVILGETKAYVFFEKDFGDMHSYVRS---RKRLREEEAARLFKQIVSAVAHC 116 Query: 120 HSRRVLHRDLKPQNLL-------------IDDKGTIKLADFGLARAFGIPIRVYTHEVVT 166 H ++ DLK + + ++D +K D L+ G P Sbjct: 117 HQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPA--------- 167 Query: 167 LWYRSPEVLLGSARYS-TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNN 225 Y SPE+L + YS D+WS+G + L + FH DS+ LF R Sbjct: 168 --YVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFH-DSDPSALFSKIRR----GQ 220 Query: 226 EVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHP 285 PE ++ L+ +L +P++R++ L HP Sbjct: 221 FCIPE------------------------HISPKARCLIRSLLRREPSERLTAPEILLHP 256 Query: 286 YFNDL 290 +F + Sbjct: 257 WFESV 261 >4RT7-A nrPDB Length = 415 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 27/93 (29%), Positives = 47/93 (50%), Gaps = 3/93 (3%) Query: 107 SYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--VYTHEV 164 + YQ+ +G+ F + +HRDL +N+L+ +K+ DFGLAR V + Sbjct: 247 CFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNAR 306 Query: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAEL 197 + + + +PE L Y+ D+WS G + E+ Sbjct: 307 LPVKWMAPESLF-EGIYTIKSDVWSYGILLWEI 338 Score = 31.6 bits (70), Expect = 0.40, Method: Compositional matrix adjust. Identities = 26/90 (28%), Positives = 39/90 (43%), Gaps = 6/90 (6%) Query: 10 IGEGTYGVVYK----GRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHPNIV 64 +G G +G V G KT + K+ E + + E+ ++ +L H NIV Sbjct: 73 LGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIV 132 Query: 65 SLQDVLMQDSRLYLIFEFLSM-DLKKYLDS 93 +L +YLIFE+ DL YL S Sbjct: 133 NLLGACTLSGPIYLIFEYCCYGDLLNYLRS 162 >6DC0-A nrPDB Length = 292 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 52/245 (21%), Positives = 92/245 (37%), Gaps = 57/245 (23%) Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 H NI + +V++ +++ Y+ FE D+ Y+ S + + QI+ + C Sbjct: 57 HSNITGIVEVILGETKAYVFFEKDFGDMHSYVRS---RKRLREEEAARLFKQIVSAVAHC 113 Query: 120 HSRRVLHRDLKPQNLL-------------IDDKGTIKLADFGLARAFGIPIRVYTHEVVT 166 H ++ DLK + + ++D +K D L+ G P Sbjct: 114 HQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPA--------- 164 Query: 167 LWYRSPEVLLGSARYS-TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNN 225 Y SPE+L + YS D+WS+G + L + FH DS+ LF R Sbjct: 165 --YVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFH-DSDPSALFSKIRR----GQ 217 Query: 226 EVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHP 285 PE ++ L+ +L +P++R++ L HP Sbjct: 218 FCIPE------------------------HISPKARCLIRSLLRREPSERLTAPEILLHP 253 Query: 286 YFNDL 290 +F + Sbjct: 254 WFESV 258 >2QLU-A nrPDB Length = 314 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/217 (25%), Positives = 96/217 (44%), Gaps = 33/217 (15%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 +E G +G V+K + VA+K L+ ++ + REI ++H N++ Sbjct: 20 LEIKARGRFGCVWKA--QLMNDFVAVKIFPLQDKQSW---QSEREIFSTPGMKHENLLQF 74 Query: 67 QDVLMQDS----RLYLIFEF---------LSMDLKKYLDSIPPGQYMDSSLVKSYLYQIL 113 + S L+LI F L ++ + + + M L SYL++ Sbjct: 75 IAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGL--SYLHE-- 130 Query: 114 QGIVFC----HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTHEVVTL 167 + +C H + HRD K +N+L+ T LADFGLA F G P +V T Sbjct: 131 -DVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTR 189 Query: 168 WYRSPEVLLGSARYSTP----VDIWSIGTIFAELATK 200 Y +PEVL G+ + +D++++G + EL ++ Sbjct: 190 RYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSR 226 >5VC6-A nrPDB Length = 289 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 34/139 (24%), Positives = 66/139 (47%), Gaps = 7/139 (5%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHP 61 ++ ++EKIG G +G V+K + G + A+K+ + A+RE+ L +H Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 71 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPG----QYMDSSLVKSYLYQILQGIV 117 ++V +D + + E+ + D+I Y + +K L Q+ +G+ Sbjct: 72 HVVRYFSAWAEDDHMLIQNEYCNGG--SLADAISENYRIMSYFKEAELKDLLLQVGRGLR 129 Query: 118 FCHSRRVLHRDLKPQNLLI 136 + HS ++H D+KP N+ I Sbjct: 130 YIHSMSLVHMDIKPSNIFI 148 >5FQD-C nrPDB Length = 341 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 51/184 (27%), Positives = 88/184 (47%), Gaps = 15/184 (8%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP-N 62 Y + KIG G++G +Y + T G+ VA+K LES++ P + E L K L+ Sbjct: 21 YKLVRKIGSGSFGDIYLAINITNGEEVAVK---LESQKARHPQL-LYESKLYKILQGGVG 76 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 I ++ + L+ + L L+ + M + L+ + Q++ I + H++ Sbjct: 77 IPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLAD--QMISRIEYVHTK 134 Query: 123 RVLHRDLKPQNLLID---DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 +HRD+KP N L+ + L DFGLA+ + R H + YR + L G+A Sbjct: 135 NFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY-RDNRTRQH----IPYREDKNLTGTA 189 Query: 180 RYST 183 RY++ Sbjct: 190 RYAS 193 >3M42-A nrPDB Length = 299 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 67/299 (22%), Positives = 116/299 (38%), Gaps = 66/299 (22%) Query: 1 MEDYTKIEKI-GEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISL-LKEL 58 ++DY ++ G G G V + +K T + A+K + + P A RE+ L + Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML------QDCPK-ARREVELHWRAS 68 Query: 59 RHPNIVSLQDVL--MQDSRLYLIFEFLSMDLKKYLDSIPP--GQYMDSSLVKSYLYQILQ 114 + P+IV + DV + R L+ +D + I Q + I + Sbjct: 69 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 128 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFGIPIRVYTHEVVTLWYRS 171 I + HS + HRD+KP+NLL K +KL DFG A+ Sbjct: 129 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE------------------- 169 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 +Y D+WS+G I L P F+ + + + P + Sbjct: 170 ----TTGEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL---------------AISPGM 210 Query: 232 ES---LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 ++ + Y+ P+W ++ VK L N +L +P +R++ +NHP+ Sbjct: 211 KTRIRMGQYEFPNPEW--SEVSEEVKMLIRN-------LLKTEPTQRMTITEFMNHPWI 260 >4L00-A nrPDB Length = 304 Score = 47.8 bits (112), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 61/291 (20%), Positives = 118/291 (40%), Gaps = 39/291 (13%) Query: 2 EDYTKIEKIGEGTYGVVYKGR---HKTTGQVVAMKKIR-----LESEEEGVPSTAIREIS 53 +D + E +G GT +Y G +K KKI+ L+ + S Sbjct: 25 KDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAAS 84 Query: 54 LLKELRHPNIVSLQDVLMQDSRLYLIFEFLS---MDLKKYLDSIPPGQYMDSSLVKSYLY 110 +++++ H +IV L V ++D ++ EF+ +DL + S + + Sbjct: 85 MMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKS----DVLTTPWKFKVAK 140 Query: 111 QILQGIVFCHSRRVLHRDLKPQNLLIDDKGT-------IKLADFGLARAFGIPIRVYTHE 163 Q+ + + + ++H ++ +NLL+ +G IKL+D G IPI V + + Sbjct: 141 QLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPG------IPITVLSRQ 194 Query: 164 --VVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG 221 + + + +PE + S S D WS GT E+ + D + + R + + Sbjct: 195 ECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRC 254 Query: 222 TPNNEVWPEVESLQDYKNTFPKWKPG------SLASHVKNLDENGLDLLSK 266 P V P + L D + P ++ + L+E D++S+ Sbjct: 255 RP---VTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSE 302 >3SV0-A nrPDB Length = 483 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 53/192 (27%), Positives = 87/192 (45%), Gaps = 41/192 (21%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPS----TAIREI----SLLKELRH 60 KIG G++G +Y G + T + VA I+LE+ + P + I I + + +R Sbjct: 14 KIGSGSFGEIYLGTNIQTNEEVA---IKLENVKTKHPQLLYESKIYRILQGGTGIPNVRW 70 Query: 61 PNIVSLQDVLMQD---SRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLY---QILQ 114 + +VL+ D L +F F S L +K+ L Q++ Sbjct: 71 FGVEGDYNVLVMDLLGPSLEDLFNFCSRKLS----------------LKTVLMLADQMIN 114 Query: 115 GIVFCHSRRVLHRDLKPQNLLID---DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRS 171 + F HS+ LHRD+KP N L+ + + DFGLA+ + TH+ + YR Sbjct: 115 RVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKY---RDTSTHQHIP--YRE 169 Query: 172 PEVLLGSARYST 183 + L G+ARY++ Sbjct: 170 NKNLTGTARYAS 181 >5L2Q-C nrPDB Length = 320 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 40/172 (23%), Positives = 77/172 (44%), Gaps = 30/172 (17%) Query: 109 LYQILQGIVFCHSRRVLHRDLKPQNLLIDDKG-TIKLADFGLARAFGIPIRVYTHEVVTL 167 Y +++ + H + ++HRDLK N++++ + I + +F L + + + + Sbjct: 159 FYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSP 218 Query: 168 WYRSPEVLLGSARYSTPVDIWSIGTI-FAELATKKPLFHGDSEIDQLFRIFRALGTPNNE 226 Y SP+VL G P D+W++G + F L + P + DS +LFR +A Sbjct: 219 AYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFY--DSIPQELFRKIKA------- 269 Query: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG 278 + T P+ + EN + L+ K+L+ DP +R++ Sbjct: 270 ----------AEYTIPED---------GRVSENTVCLIRKLLVLDPQQRLAA 302 >2CMW-A nrPDB Length = 310 Score = 47.8 bits (112), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 50/181 (27%), Positives = 83/181 (45%), Gaps = 18/181 (9%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 +KIG G +G + G++ T + VA I+LE + P + E K+L Q Sbjct: 6 KKIGCGNFGELRLGKNLYTNEYVA---IKLEPIKSRAPQLHL-EYRFYKQLGSAGEGLPQ 61 Query: 68 DVLMQDSRLY--LIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 125 Y ++ E L L+ D + + L+ + Q+L + + HS+ ++ Sbjct: 62 VYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAI--QLLSRMEYVHSKNLI 119 Query: 126 HRDLKPQNLLIDDKGT-----IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 +RD+KP+N LI +G I + DFGLA+ + P H + YR + L G+AR Sbjct: 120 YRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDP-ETKKH----IPYREHKSLTGTAR 174 Query: 181 Y 181 Y Sbjct: 175 Y 175 >5M07-A nrPDB Length = 276 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 42/161 (26%), Positives = 73/161 (45%), Gaps = 23/161 (14%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIR--LESEEEGVPSTAIREISLLKELRHP 61 YT + +G G VY +H A+K + + +++E RE + L HP Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDE-FRRRFQRETEVAARLFHP 90 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSL--------VKSYLYQIL 113 +I+ + D D +L++ +MD Y+D I Q+M V + + + Sbjct: 91 HILEVHDRGEFDGQLWI-----AMD---YVDGIDATQHMADRFPAVLPVGEVLAIVTAVA 142 Query: 114 QGIVFCHSRRVLHRDLKPQNLLIDDKGT----IKLADFGLA 150 + + H R +LHRD+ P N+++ + I LADFG+A Sbjct: 143 GALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIA 183 >4I94-A nrPDB Length = 300 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 52/200 (26%), Positives = 90/200 (45%), Gaps = 17/200 (8%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 + + GE VVYKG+ + + +A+K+ +S + + E + +LR+ + +L Sbjct: 34 VSEHGERAPNVVYKGKLENQ-RRIAVKRFNRKSWPDS--RQFLEEAKAVGQLRNHRMANL 90 Query: 67 QDVLMQDSRLYLIFEFLSMD-LKKYL---DSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 +D LI EF+ + L K+L +S P M ++ I Q + +C S+ Sbjct: 91 LGCCYEDEERLLIAEFMPNETLAKHLFHWESQP----MKWAMRLRVALHIAQALEYCTSK 146 Query: 123 -RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 R L+ DL +L DD +L+ FGL + R L + PE L + R Sbjct: 147 GRALYHDLNAYRVLFDDDANPRLSCFGLMKN----SRDGKSYSTNLAFTPPEYLR-TGRV 201 Query: 182 STPVDIWSIGTIFAELATKK 201 + I+S GT+ +L + K Sbjct: 202 TPESVIYSFGTLLLDLLSGK 221 >4NT4-A nrPDB Length = 312 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 29/78 (37%), Positives = 44/78 (56%), Gaps = 10/78 (12%) Query: 111 QILQGIVFCHSRRVLHRDLKPQNLLIDDKGT-----IKLADFGLARAFGIPIRVYTHEVV 165 Q+L I + HSR +++RD+KP+N LI T I + DFGLA+ + I + H Sbjct: 122 QLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEY-IDLDTNRH--- 177 Query: 166 TLWYRSPEVLLGSARYST 183 + YR + L G+ARY + Sbjct: 178 -IPYREHKSLTGTARYMS 194 >2C47-A nrPDB Length = 313 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 47/183 (25%), Positives = 85/183 (46%), Gaps = 23/183 (12%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH----PNI 63 +KIG G +G + G++ T + VA I+LE + P + E K+L P + Sbjct: 10 KKIGCGNFGELRLGKNLYTNEYVA---IKLEPIKSRAPQLHL-EYRFYKQLSATEGVPQV 65 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 ++ ++ E L L+ D + + L+ + Q++ + + H++ Sbjct: 66 YYFGPCGKYNA---MVLELLGPSLEDLFDLCDRTFTLKTVLMIAI--QLITRMEYVHTKS 120 Query: 124 VLHRDLKPQNLLIDDKGT-----IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 +++RD+KP+N L+ GT I + DFGLA+ + P H + YR + L G+ Sbjct: 121 LIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDP-ETKKH----IPYREHKSLTGT 175 Query: 179 ARY 181 ARY Sbjct: 176 ARY 178 >4O1O-A nrPDB Length = 717 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 42/145 (28%), Positives = 70/145 (48%), Gaps = 17/145 (11%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR-HPNIVSLQ 67 KI + G +Y G ++ Q VA+K+ EG + +E+S L+ R + N+V+ Sbjct: 353 KIADTAEGGIYLGLYED--QEVAVKRF-----SEG-STRGQQEVSCLQSSRANDNVVTFY 404 Query: 68 DVLMQDSRLYLIFEFLSMDLKKYL-----DSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 S L++ L+++L D++P + D S ++ L + + I H Sbjct: 405 GSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEE--DES-ARNILSSLFKAIGELHRS 461 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADF 147 H+DL+PQN+LID K LADF Sbjct: 462 GYSHQDLQPQNILIDSKNGTFLADF 486 >3MY0-A nrPDB Length = 305 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 58/221 (26%), Positives = 87/221 (39%), Gaps = 41/221 (18%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 +E +G+G YG V++G G+ VA+K E+ T I LL RH NI+ Sbjct: 13 VECVGKGRYGEVWRGLWH--GESVAVKIFSSRDEQSWFRETEIYNTVLL---RHDNILGF 67 Query: 67 --QDVLMQDS--RLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 D+ ++S +L+LI + L +L Q ++ L G+ H Sbjct: 68 IASDMTSRNSSTQLWLITHYHEHGSLYDFLQR----QTLEPHLALRLAVSAACGLAHLHV 123 Query: 122 R--------RVLHRDLKPQNLLIDDKGTIKLADFGLARA---------FGIPIRVYTHEV 164 + HRD K +N+L+ +AD GLA G RV T Sbjct: 124 EIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKR- 182 Query: 165 VTLWYRSPEVLLGSARYST-----PVDIWSIGTIFAELATK 200 Y +PEVL R DIW+ G + E+A + Sbjct: 183 ----YMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARR 219 >4XHH-A nrPDB Length = 403 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 58/207 (28%), Positives = 90/207 (43%), Gaps = 71/207 (34%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 KIG G++G +Y G + +G+ VA IRLES IR RHP Sbjct: 14 KIGSGSFGDIYHGTNLISGEEVA---IRLES---------IRS-------RHPQ------ 48 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIP-------PGQY-------MDSSLVKSYLY---- 110 L +SR+Y ++LS + IP G+Y + SL + Y Sbjct: 49 -LDYESRVY---KYLSGGV-----GIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRK 99 Query: 111 -----------QILQGIVFCHSRRVLHRDLKPQNLL--IDDKG-TIKLADFGLARAFGIP 156 Q++ + + H R +HRD+KP N L + +G T+ + DFGL++ + Sbjct: 100 FSFKTVIMLALQMICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYR-- 157 Query: 157 IRVYTHEVVTLWYRSPEVLLGSARYST 183 TH + YR + L G+ARY++ Sbjct: 158 -DFNTHRHIP--YRENKSLTGTARYAS 181 >4XHL-A nrPDB Length = 394 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 88/207 (42%), Gaps = 71/207 (34%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 KIG G++G +Y G + +G+ VA IRLES IR RHP Sbjct: 14 KIGSGSFGDIYHGTNLISGEEVA---IRLES---------IRS-------RHPQ------ 48 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIP-------PGQY-------MDSSLVKSYLY---- 110 L +SR+Y +LS + IP G+Y + SL + Y Sbjct: 49 -LDYESRVY---RYLSGGV-----GIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRR 99 Query: 111 -----------QILQGIVFCHSRRVLHRDLKPQNLL--IDDKG-TIKLADFGLARAFGIP 156 Q+ I + H R +HRD+KP N L + +G T+ + DFGL++ + Sbjct: 100 FSFKTVIMLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYR-- 157 Query: 157 IRVYTHEVVTLWYRSPEVLLGSARYST 183 TH + YR + L G+ARY++ Sbjct: 158 -DFNTHRHIP--YRENKSLTGTARYAS 181 >5E8V-A nrPDB Length = 316 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 53/219 (24%), Positives = 93/219 (42%), Gaps = 36/219 (16%) Query: 10 IGEGTYGVVYKGRHK-TTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 +G+G + VYK + K T + +++ EE ++I L+H NI+ Sbjct: 17 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLT 76 Query: 69 VLMQDSRL----YLIFEFLSM-DLKKYLD----SIPPGQYMDSSLVKSYLYQILQGIVFC 119 + + L +LI F + +L++YL S + + SSL + GI Sbjct: 77 AEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLAR--------GIAHL 128 Query: 120 HSRR---------VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV----YTHEVVT 166 HS ++HRDLK N+L+ + T L DFGL+ + V + +V T Sbjct: 129 HSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGT 188 Query: 167 LWYRSPEVLLGSARYST-----PVDIWSIGTIFAELATK 200 Y +PEVL + D++S+ + E+ ++ Sbjct: 189 ARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSR 227 >4JRN-A nrPDB Length = 372 Score = 44.3 bits (103), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 47/203 (23%), Positives = 79/203 (38%), Gaps = 58/203 (28%) Query: 104 LVKSYLY-QILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFG-------LARAFGI 155 +V+ YL Q ++ + ++ ++H D+KP N L+ G + L DFG + RA G Sbjct: 202 VVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRINNSVGRAIGT 261 Query: 156 PIRVYTHEVVTLWYRSPEVLLGSA--RYSTPVDIWSIG-TIFAELATKKPLFHGDSEIDQ 212 P Y PE + Y+ P D W +G T++ ++P Sbjct: 262 P-----------GYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP---------- 300 Query: 213 LFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDP 272 TP + +W DY + + + E DL+ +L DP Sbjct: 301 ---------TPADGIW-------DYLHF----------ADCPSTPELVQDLIRSLLNRDP 334 Query: 273 AKRISGKMALNHPYFNDLDNQIK 295 KR+ AL F ++D+ +K Sbjct: 335 QKRMLPLQALETAAFKEMDSVVK 357 >4OAU-C nrPDB Length = 699 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 42/144 (29%), Positives = 69/144 (47%), Gaps = 14/144 (9%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR-HPNIVSLQ 67 KI + + G +Y G ++ Q VA+K EG P A RE+S L+ R + ++V+ Sbjct: 350 KIADTSEGGIYLGFYEK--QEVAVKTFC-----EGSPR-AQREVSCLQSSRENSHLVTFY 401 Query: 68 DVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSS---LVKSYLYQILQGIVFCH-SRR 123 L++ L+ LD + G+ +++ ++ L I + + H S Sbjct: 402 GSESHRGHLFVCVTLCEQTLEACLD-VHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG 460 Query: 124 VLHRDLKPQNLLIDDKGTIKLADF 147 H+DL+PQN+LID K LADF Sbjct: 461 YTHQDLQPQNILIDSKKAAHLADF 484 >2CHL-A nrPDB Length = 351 Score = 43.9 bits (102), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 47/185 (25%), Positives = 84/185 (45%), Gaps = 23/185 (12%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH----PNI 63 +KIG G +G + G++ T + VA I+LE + P + E K+L P + Sbjct: 36 KKIGCGNFGELRLGKNLYTNEYVA---IKLEPMKSRAPQLHL-EYRFYKQLGSGDGIPQV 91 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 ++ ++ E L L+ D + + L+ + Q++ + + HS+ Sbjct: 92 YYFGPCGKYNA---MVLELLGPSLEDLFDLCDRTFSLKTVLMIAI--QLISRMEYVHSKN 146 Query: 124 VLHRDLKPQNLLIDDKGT-----IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 +++RD+KP+N LI G I + DF LA+ + P H + YR + L G+ Sbjct: 147 LIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDP-ETKKH----IPYREHKSLTGT 201 Query: 179 ARYST 183 ARY + Sbjct: 202 ARYMS 206 >4IX6-A nrPDB Length = 350 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 52/215 (24%), Positives = 83/215 (38%), Gaps = 47/215 (21%) Query: 103 SLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDK--GTIKLADFGLARAFGIPIR-- 158 + K + ++L + H V+HRD+KP NL+ +K G +KL D G A A +P+ Sbjct: 143 GVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAA-ALCLPLPET 201 Query: 159 --------------VYTHEVVTLWYRSPE------VLLGSARYSTPVDIWSIGTIFAELA 198 E+ L SP L A D WS G + +LA Sbjct: 202 LNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQLA 261 Query: 199 TKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK-NTFPKWKPGSLAS-HVKNL 256 D+ +++ ++A+G Y N F K G + L Sbjct: 262 VVG--LRTDAGLERFLADYKAVG---------------YDVNAFRGEKSGEYGTMDFAAL 304 Query: 257 DEN---GLDLLSKMLIYDPAKRISGKMALNHPYFN 288 D N G DL +++ + R S + AL+H +F+ Sbjct: 305 DANGGAGWDLCQRLMEAERDARASCEAALSHAFFD 339 >5J0A-A nrPDB Length = 300 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 40/161 (24%), Positives = 72/161 (44%), Gaps = 15/161 (9%) Query: 51 EISLLKELRHPNIVSLQDVL-MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDS------S 103 E +LK L HPNIV + D L L E+ +K L+ + +Y S + Sbjct: 64 EAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGG---EKSLNDLIEERYKASQDPFPAA 120 Query: 104 LVKSYLYQILQGIVFCH-SRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYT 161 ++ + +G+ + H +++LH D+K N++I D TIK+ D G++ + V Sbjct: 121 IILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTD 180 Query: 162 HEVV---TLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT 199 E T ++ E + + + DI++ G E+ T Sbjct: 181 PEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMT 221 >5USZ-A nrPDB Length = 289 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 52/230 (22%), Positives = 97/230 (42%), Gaps = 34/230 (14%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIR-----LESEEEGVPSTAIREISLLK 56 ED E +G+GT+ ++KG + G + + L+ + S++ Sbjct: 8 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMS 67 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFL---SMD--LKKYLDSIPPGQYMDSSLVKSYLYQ 111 +L H ++V V + L+ EF+ S+D LKK + I ++ + Q Sbjct: 68 KLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVA------KQ 121 Query: 112 ILQGIVFCHSRRVLHRDLKPQNLLI---DDKGT-----IKLADFGLARAFGIPIRVYTHE 163 + + F ++H ++ +N+L+ +D+ T IKL+D GI I V + Sbjct: 122 LAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSD------PGISITVLPKD 175 Query: 164 VVT--LWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT--KKPLFHGDSE 209 ++ + + PE + + D WS GT E+ + KPL DS+ Sbjct: 176 ILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQ 225 >4BTF-A nrPDB Length = 469 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 38/166 (22%), Positives = 70/166 (42%), Gaps = 13/166 (7%) Query: 51 EISLLKELRHPNIVSLQDVLMQDS----RLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLV 105 EI +K+ PNI+ + + + + ++ E+ + L++ LD + + S+ Sbjct: 244 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDR---EKDLTMSVR 300 Query: 106 KSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY----T 161 + + +G+ H LHR++ + L+ +KLA F L++ R Sbjct: 301 SLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKA 360 Query: 162 HEVVTLWYRSPEVLLGS-ARYSTPVDIWSIGTIFAELATKKPLFHG 206 + Y SPE L Y +I+S G + E+AT K F G Sbjct: 361 ERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEG 406 >4M69-B nrPDB Length = 283 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 38/166 (22%), Positives = 70/166 (42%), Gaps = 13/166 (7%) Query: 51 EISLLKELRHPNIVSLQDVLMQDS----RLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLV 105 EI +K+ PNI+ + + + + ++ E+ + L++ LD + + S+ Sbjct: 58 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDR---EKDLTMSVR 114 Query: 106 KSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY----T 161 + + +G+ H LHR++ + L+ +KLA F L++ R Sbjct: 115 SLLVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKA 174 Query: 162 HEVVTLWYRSPEVLLGS-ARYSTPVDIWSIGTIFAELATKKPLFHG 206 + Y SPE L Y +I+S G + E+AT K F G Sbjct: 175 ERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEG 220 >4L68-A nrPDB Length = 340 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 43/164 (26%), Positives = 76/164 (46%), Gaps = 25/164 (15%) Query: 51 EISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYL 109 E++ L ELRH N+ L + + +L+++++S L LDS G+ +D S Sbjct: 85 EMNQLWELRHSNLAPLLGFCVVEEEKFLVYKYMSNGTLHSLLDS-NRGE-LDWSTRFRIG 142 Query: 110 YQILQGIVFCHSRR---VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP-----IRVYT 161 +G+ + H +LH+++ +LID+ ++ D GLAR +P T Sbjct: 143 LGAARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLM-VPSDNNESSFMT 201 Query: 162 HEVVTLWYRSPEVLLGSARYSTPV------DIWSIGTIFAELAT 199 ++ Y +PE YST + D++ +G + ELAT Sbjct: 202 GDLGEFGYVAPE-------YSTTMLASLKGDVYGLGVVLLELAT 238 >5OAT-A nrPDB Length = 411 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 40/186 (21%), Positives = 78/186 (41%), Gaps = 37/186 (19%) Query: 60 HPNIVSLQDVLM-----------------QDSRLYLIFEFLSMDLKKYLDSIPPGQYMDS 102 HPNIV++ V ++ L+L+ + +L+ +L + P + Sbjct: 98 HPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLFLLMKRYDCNLQSFLSTAP-----ST 152 Query: 103 SLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID----DKGTIKLADFGLA---RAFGI 155 L Q+L+G+ + + HRDLK NLL+D + + ++DFG + G+ Sbjct: 153 RTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGL 212 Query: 156 PIRVYTHEV---VTLWYRSPEVLLG-----SARYSTPVDIWSIGTIFAELATKKPLFHGD 207 + ++E+ +PE++ S + D+W++G I E+ F+G Sbjct: 213 SLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFYGP 272 Query: 208 SEIDQL 213 S + Sbjct: 273 SRLKNF 278 >3REP-A nrPDB Length = 271 Score = 38.5 bits (88), Expect = 0.003, Method: Compositional matrix adjust. Identities = 44/211 (20%), Positives = 84/211 (39%), Gaps = 13/211 (6%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 + K+ E G ++KGR + VV + K+R S + E L+ HPN++ + Sbjct: 15 LTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKS--RDFNEECPRLRIFSHPNVLPV 72 Query: 67 QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQ--YMDSSLVKSYLYQILQGIVFCHSRRV 124 + M + + G +D S + + +G+ F H+ Sbjct: 73 LGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEP 132 Query: 125 L--HRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 L L ++++ID+ T +++ + +F P R+Y V +PE L + Sbjct: 133 LIPRHALNSRSVMIDEDMTARISMADVKFSFQSPGRMYAPAWV-----APEALQKKPEDT 187 Query: 183 T--PVDIWSIGTIFAELATKKPLFHGDSEID 211 D+WS + EL T++ F S ++ Sbjct: 188 NRRSADMWSFAVLLWELVTREVPFADLSNME 218 >5UV4-A nrPDB Length = 311 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 90/215 (41%), Gaps = 36/215 (16%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTA---IREISLLKELRHPNIV 64 E IG +G YK G ++ +K ++ EG + REI L +RHPN+V Sbjct: 31 EIIGRSCHGTSYKATLDN-GYMLTVKWLK-----EGFAKSKKEFSREIKKLGSVRHPNLV 84 Query: 65 SLQDVL---MQDSRLYLIFEFLSMDLKKYLD-----SIPP---GQYMDSSLVKSYLYQIL 113 L+ + R+ + + L YL ++PP GQ ++ ++ I Sbjct: 85 PLRGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAI------DIA 138 Query: 114 QGIVFCHSRRVL-HRDLKPQNLLIDDKGTIKL-ADFGLARAFGIPIRVYTH--EVVTLWY 169 + + + H+ RV+ H ++K N+LI + L D+ L R PI + L Y Sbjct: 139 RCLDYLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLM-TPIGMAEQVLNAGALGY 197 Query: 170 RSPEVLLGSARYSTP---VDIWSIGTIFAELATKK 201 PE S P D+++ G I EL T K Sbjct: 198 SPPE--FSSTSKPCPSLKSDVYAFGVILLELLTGK 230 >4MWI-A nrPDB Length = 294 Score = 36.2 bits (82), Expect = 0.016, Method: Compositional matrix adjust. Identities = 51/211 (24%), Positives = 91/211 (43%), Gaps = 23/211 (10%) Query: 12 EGTYGVVYKGR-HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVL 70 E +YKG H+ + KK++ S V T +EI +K+ PNI+ + + Sbjct: 34 ENEVSTLYKGEYHRAPVAIKVFKKLQAGSIA-IVRQTFNKEIKTMKKFESPNILRIFGIC 92 Query: 71 MQDS----RLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQI--LQGIVFCHSRR 123 + ++ + ++ E+ + L++ LD + D +L K + + +G+ H Sbjct: 93 IDETVTPPQFSIVMEYCELGTLRELLD-----REKDLTLGKRMVLVLGAARGLYRLHHSE 147 Query: 124 V--LHRDLKPQNLLIDDKGTIKLADFGLAR-----AFGIPIRVYTHEVVTLWYRSPEVLL 176 LH ++ N L+ +KLA F L + + G R T V + Y SP+ L Sbjct: 148 APELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGT-TREKTDRVKSTAYLSPQELE 206 Query: 177 GS-ARYSTPVDIWSIGTIFAELATKKPLFHG 206 +Y +I+S G + E+AT F G Sbjct: 207 DVFYQYDVKSEIYSFGIVLWEIATGDIPFQG 237 >4CYJ-A nrPDB Length = 438 Score = 36.2 bits (82), Expect = 0.018, Method: Compositional matrix adjust. Identities = 32/140 (22%), Positives = 65/140 (46%), Gaps = 14/140 (10%) Query: 18 VYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQ----D 73 VYK ++ G+ A++ RLE + + K++++ +IV++ +V D Sbjct: 71 VYKAQNSRNGRHYALR--RLEGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFTTREFGD 128 Query: 74 SRLYLIFEF--LSMDLKKYL------DSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 125 S L ++F LS L+++ + P + + + Y+ QI + HS R+ Sbjct: 129 SSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHSNRLA 188 Query: 126 HRDLKPQNLLIDDKGTIKLA 145 R L+P +++ D I+L+ Sbjct: 189 ARCLEPSKIILTDINRIRLS 208 >5CLR-A nrPDB Length = 451 Score = 35.0 bits (79), Expect = 0.038, Method: Compositional matrix adjust. Identities = 24/81 (29%), Positives = 46/81 (56%), Gaps = 16/81 (19%) Query: 77 YLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF--CHSRR------VLHR 127 Y++ F+ +DL +Y +++P ++ +L + +++L GI+ CH + ++HR Sbjct: 148 YILTTFIKGIDLSRYKNALP----LNVNL--KHFWEVL-GIMISVCHQVKQFHELGLIHR 200 Query: 128 DLKPQNLLIDDKGTIKLADFG 148 DLKP N+++D L DFG Sbjct: 201 DLKPGNIMLDADMQCHLVDFG 221 >6J6I-B nrPDB Length = 351 Score = 33.9 bits (76), Expect = 0.080, Method: Compositional matrix adjust. Identities = 28/126 (22%), Positives = 53/126 (42%), Gaps = 26/126 (20%) Query: 111 QILQGIVFCHS---RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTL 167 +I + + H+ + ++HRD+KP ++ +D T KL+D +F I + + Sbjct: 171 EIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDL----SFSISLPEGKSRIEAE 226 Query: 168 WYRSPEVLLGSARYSTPV-----------DIWSIGTIFAELATKKPLFH--GDSEIDQLF 214 W +LG+ Y P+ D++S G + T KP D ++ + Sbjct: 227 W------VLGTFGYIDPLYHKTCFVTEYTDVYSFGICLLVIITGKPAIMTISDGDLQGIL 280 Query: 215 RIFRAL 220 + R L Sbjct: 281 SLVREL 286 >5UU1-A nrPDB Length = 324 Score = 33.9 bits (76), Expect = 0.096, Method: Compositional matrix adjust. Identities = 38/170 (22%), Positives = 73/170 (42%), Gaps = 39/170 (22%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 +KIG G +G++Y + A +++E +E G L EL+ V+ + Sbjct: 22 KKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENG---------PLFSELKFYQRVAKK 72 Query: 68 DVLMQ-------------------------DSRLYLIFEFLSMDLKKYLDSIPPGQYMDS 102 D + + S +++ E L +DL+K S G + S Sbjct: 73 DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI--SGQNGTFKKS 130 Query: 103 SLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKG--TIKLADFGLA 150 ++++ + ++L + + H +H D+K NLL+ K + LAD+GL+ Sbjct: 131 TVLQLGI-RMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLS 179 >3G8O-A nrPDB Length = 263 Score = 33.1 bits (74), Expect = 0.14, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 36/79 (45%), Gaps = 6/79 (7%) Query: 132 QNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR------YSTPV 185 +NL IDD+ T+ + FG+ R Y H + Y +P+++L R YS + Sbjct: 70 RNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCL 129 Query: 186 DIWSIGTIFAELATKKPLF 204 +W I F +L + F Sbjct: 130 TMWQIPQEFVKLQVSQEEF 148 >5DMZ-A nrPDB Length = 365 Score = 33.1 bits (74), Expect = 0.15, Method: Compositional matrix adjust. Identities = 32/139 (23%), Positives = 60/139 (43%), Gaps = 14/139 (10%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 +GEG + VY+ +K L+ ++ P L++ L+ S+Q + Sbjct: 73 LGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLK----PSMQHM 128 Query: 70 LMQ--DSRLYLIFEFLSMDLKKY---LDSI-----PPGQYMDSSLVKSYLYQILQGIVFC 119 M+ + L+ L +L Y L++I P + M LV S+ ++L I Sbjct: 129 FMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQV 188 Query: 120 HSRRVLHRDLKPQNLLIDD 138 H ++H D+KP N ++ + Sbjct: 189 HDCEIIHGDIKPDNFILGN 207 >4BWP-A nrPDB Length = 448 Score = 33.1 bits (74), Expect = 0.15, Method: Compositional matrix adjust. Identities = 19/74 (25%), Positives = 38/74 (51%), Gaps = 13/74 (17%) Query: 16 GVVYKGRHKTTGQVVAMKKI---RLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQ 72 Y+ H TTG +++I RL+S + + + + K+L+H N+V L++V Sbjct: 64 ATTYRATHNTTGYKYCLRRIHGFRLQS------TKCMTLVEMWKKLQHTNVVQLREVFTT 117 Query: 73 ----DSRLYLIFEF 82 D+ L L++++ Sbjct: 118 KAFGDNSLVLVYDY 131 >3L9Y-A nrPDB Length = 154 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 18/74 (24%), Positives = 36/74 (48%), Gaps = 1/74 (1%) Query: 6 KIEKIGEGTYGV-VYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIV 64 +++ + +G +G V++ T G A E ++ G PS+A+R + L + Sbjct: 33 EVQGLTKGKHGFHVHEFGDNTNGCTSAGAHFNPEKQDHGGPSSAVRHVGDLGNIEAIEDA 92 Query: 65 SLQDVLMQDSRLYL 78 + V +QDS++ L Sbjct: 93 GVTKVSIQDSQISL 106 >4AZW-A nrPDB Length = 471 Score = 29.3 bits (64), Expect = 2.0, Method: Compositional matrix adjust. Identities = 14/57 (24%), Positives = 29/57 (50%), Gaps = 3/57 (5%) Query: 92 DSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFG 148 D + G+ +D + L +L+ + + H D++P N+++D + +L DFG Sbjct: 331 DMLAAGEEIDREKI---LGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDFG 384 >4AZV-A nrPDB Length = 569 Score = 29.3 bits (64), Expect = 2.3, Method: Compositional matrix adjust. Identities = 14/57 (24%), Positives = 29/57 (50%), Gaps = 3/57 (5%) Query: 92 DSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFG 148 D + G+ +D + L +L+ + + H D++P N+++D + +L DFG Sbjct: 331 DMLAAGEEIDREKI---LGSLLRSLAALEKQGFWHDDVRPWNVMVDARQHARLIDFG 384 >5XAR-A nrPDB Length = 438 Score = 29.3 bits (64), Expect = 2.3, Method: Compositional matrix adjust. Identities = 22/76 (28%), Positives = 34/76 (44%), Gaps = 17/76 (22%) Query: 137 DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDI-------WS 189 KG L F + FG+P+ +Y ++TL LL + P DI + Sbjct: 1 GSKGVSDLLGF---KIFGMPLPLYAFALITL-------LLSHFYNALPTDIVGGFAIMFI 50 Query: 190 IGTIFAELATKKPLFH 205 IG IF E+ + P+F+ Sbjct: 51 IGAIFGEIGKRLPIFN 66 >2RSV-A nrPDB Length = 403 Score = 28.9 bits (63), Expect = 2.9, Method: Compositional matrix adjust. Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 4/76 (5%) Query: 77 YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLI 136 ++I + DL+K ++ + V +IL + + H +H D+K NLL+ Sbjct: 135 FMIMDRFGSDLQKIYEA--NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLL 192 Query: 137 DDKG--TIKLADFGLA 150 + K + L D+GLA Sbjct: 193 NYKNPDQVYLVDYGLA 208 >1OTJ-A nrPDB Length = 283 Score = 28.9 bits (63), Expect = 2.9, Method: Compositional matrix adjust. Identities = 36/169 (21%), Positives = 67/169 (39%), Gaps = 16/169 (9%) Query: 87 LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLAD 146 + + L P G Y+ + + + L + L F ++ H L+ Q + + D+ Sbjct: 1 MSERLSITPLGPYIGAQISGADLTRPLSDNQF---EQLYHAVLRHQVVFLRDQAITPQQQ 57 Query: 147 FGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDI--WSIGTIFAE-------L 197 LA+ FG ++ H V E+++ P D W F E L Sbjct: 58 RALAQRFG---ELHIHPVYPHAEGVDEIIVLDTHNDNPPDNDNWHTDVTFIETPPAGAIL 114 Query: 198 ATKK-PLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWK 245 A K+ P GD+ + AL P ++ + + D++ +FP++K Sbjct: 115 AAKELPSTGGDTLWTSGIAAYEALSVPFRQLLSGLRAEHDFRKSFPEYK 163 >2LAV-A nrPDB Length = 361 Score = 28.5 bits (62), Expect = 3.5, Method: Compositional matrix adjust. Identities = 21/79 (26%), Positives = 37/79 (46%), Gaps = 4/79 (5%) Query: 74 SRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQN 133 S ++I + DL+K ++ + V +IL + + H +H D+K N Sbjct: 125 SYRFMIMDRFGSDLQKIYEA--NAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASN 182 Query: 134 LLIDDKG--TIKLADFGLA 150 LL++ K + L D+GLA Sbjct: 183 LLLNYKNPDQVYLVDYGLA 201 >6EQI-C nrPDB Length = 433 Score = 28.1 bits (61), Expect = 4.6, Method: Compositional matrix adjust. Identities = 23/80 (28%), Positives = 37/80 (46%), Gaps = 9/80 (11%) Query: 76 LYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLL 135 L+L+ + LK+YL P L+ +L+ + + + HRDLK N+L Sbjct: 144 LFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQ----LLEAVAHMNIHNISHRDLKSDNIL 199 Query: 136 ID-DKG----TIKLADFGLA 150 +D +G TI + DFG Sbjct: 200 VDLSEGDAYPTIVITDFGCC 219 >1XSK-A nrPDB Length = 778 Score = 28.1 bits (61), Expect = 4.7, Method: Compositional matrix adjust. Identities = 26/89 (29%), Positives = 38/89 (42%), Gaps = 12/89 (13%) Query: 215 RIFRALGTPNNEVWPEVESLQDYKNT------FPKWKPGSLASHVKNLDENGLDLLSKML 268 RI G NN + LQD K T + ++K G+L++ V + LD L Sbjct: 68 RIEHFQGALNNGPHYPLNILQDVKVTIENTERYAEFKSGNLSARVSKGEFWSLDFLRN-- 125 Query: 269 IYDPAKRISGKMALNHPYFNDLDNQIKKM 297 +RI+G N+ Y D +NQ M Sbjct: 126 ----GERITGSQVKNNGYVQDTNNQRNYM 150 >6G4J-A nrPDB Length = 315 Score = 28.1 bits (61), Expect = 4.8, Method: Compositional matrix adjust. Identities = 37/171 (21%), Positives = 68/171 (39%), Gaps = 27/171 (15%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 YT +++G+G G+VY + G V L+ ++ + T+ E+++LK Sbjct: 28 YTLRKQLGKGANGIVYLA-ETSDGHVA------LKVSDDSLSITS--EVNVLKSFSKAQS 78 Query: 64 VSLQDVLMQDSRLYL-----IFEFLSMD------LKKYLDSIPPGQYMDSSLVKSYLYQI 112 V++ Y+ F +M+ L KY+ + + + Q+ Sbjct: 79 VTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSD------KGAEWIPVLMIQL 132 Query: 113 LQGIVFCHSRRVLHRDLKPQNLLIDD-KGTIKLADFGLARAFGIPIRVYTH 162 L + H + + DLKP NL++ I+ D G G I+ YT Sbjct: 133 LSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTE 183 >5T9T-A nrPDB Length = 535 Score = 28.1 bits (61), Expect = 5.4, Method: Compositional matrix adjust. Identities = 19/61 (31%), Positives = 30/61 (49%), Gaps = 5/61 (8%) Query: 204 FHG-DSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASH----VKNLDE 258 FH D +++++F + + G + + E+ + Y PG LASH VK LDE Sbjct: 251 FHNVDEQVERIFNLDKRTGEITTKDNLDFETAKSYTLNVEAKDPGDLASHCSIQVKILDE 310 Query: 259 N 259 N Sbjct: 311 N 311 >5SZR-A nrPDB Length = 441 Score = 27.7 bits (60), Expect = 5.5, Method: Compositional matrix adjust. Identities = 19/61 (31%), Positives = 30/61 (49%), Gaps = 5/61 (8%) Query: 204 FHG-DSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASH----VKNLDE 258 FH D +++++F + + G + + E+ + Y PG LASH VK LDE Sbjct: 44 FHNVDEQVERIFNLDKRTGEITTKDNLDFETAKSYTLNVEAKDPGDLASHCSIQVKILDE 103 Query: 259 N 259 N Sbjct: 104 N 104 >4CI6-B nrPDB Length = 643 Score = 26.9 bits (58), Expect = 9.6, Method: Compositional matrix adjust. Identities = 17/66 (25%), Positives = 33/66 (50%), Gaps = 6/66 (9%) Query: 124 VLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 ++H D+KP N++ D G + D GL G + +T +++PE+ +G+ S Sbjct: 177 IVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGFTES-----FKAPELGVGNLGAS 231 Query: 183 TPVDIW 188 D++ Sbjct: 232 EKSDVF 237 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6GU6-A nrPDB 423 e-119 2BPM-A nrPDB 380 e-106 3NIZ-A nrPDB 346 6e-96 1V0B-A nrPDB 344 3e-95 4AU8-A nrPDB 336 8e-93 4KRC-A nrPDB 328 2e-90 5G6V-A nrPDB 316 1e-86 3GC0-A nrPDB 313 7e-86 1UA2-A nrPDB 308 2e-84 5EFQ-A nrPDB 302 1e-82 1G3N-A nrPDB 301 3e-82 4NST-A nrPDB 300 4e-82 1CM8-A nrPDB 298 2e-81 4AGU-A nrPDB 297 3e-81 5Z33-A nrPDB 296 6e-81 4BBM-A nrPDB 293 6e-80 4EWQ-A nrPDB 292 8e-80 6DTL-A nrPDB 292 1e-79 2F9G-A nrPDB 291 2e-79 3OHT-A nrPDB 290 5e-79 4MYG-A nrPDB 290 5e-79 4IC8-A nrPDB 287 3e-78 3NCG-A nrPDB 286 6e-78 4QTB-A nrPDB 286 9e-78 2W96-B nrPDB 285 1e-77 3GC9-A nrPDB 284 3e-77 4ZSG-A nrPDB 283 6e-77 3DFA-A nrPDB 283 8e-77 3OZ6-A nrPDB 282 9e-77 5NGU-A nrPDB 282 1e-76 3MIA-A nrPDB 282 1e-76 5JN2-A nrPDB 282 2e-76 3LIJ-A nrPDB 280 4e-76 4MVF-A nrPDB 280 7e-76 4QNY-A nrPDB 278 2e-75 3HZT-A nrPDB 277 5e-75 3MA6-A nrPDB 275 1e-74 2VN9-A nrPDB 275 2e-74 3DXN-A nrPDB 275 2e-74 1JNK-A nrPDB 274 2e-74 4BGQ-A nrPDB 274 2e-74 5AWM-A nrPDB 274 4e-74 3E7O-A nrPDB 273 7e-74 3FI2-A nrPDB 272 1e-73 3ZDU-A nrPDB 272 1e-73 2XS0-A nrPDB 272 1e-73 5U6Y-A nrPDB 272 2e-73 5FG8-A nrPDB 271 3e-73 2V7O-A nrPDB 270 4e-73 2BDW-A nrPDB 270 7e-73 5AIR-A nrPDB 269 8e-73 2VZ6-A nrPDB 269 1e-72 4E7W-A nrPDB 268 2e-72 3COM-A nrPDB 267 3e-72 4YZB-A nrPDB 267 5e-72 3RP9-A nrPDB 266 7e-72 3KK8-A nrPDB 266 8e-72 3SOA-A nrPDB 266 8e-72 3BHH-A nrPDB 265 2e-71 3N9X-A nrPDB 264 3e-71 5IG1-A nrPDB 264 4e-71 4O2Z-A nrPDB 263 5e-71 4LG4-A nrPDB 262 1e-70 4FG9-A nrPDB 262 2e-70 3Q5I-A nrPDB 261 2e-70 2JC6-A nrPDB 261 3e-70 6AO5-A nrPDB 260 7e-70 3NIE-A nrPDB 259 1e-69 4RGJ-A nrPDB 259 2e-69 5ES1-A nrPDB 257 4e-69 3TAC-A nrPDB 256 8e-69 3MN3-A nrPDB 256 8e-69 5YKS-A nrPDB 256 9e-69 4UZD-A nrPDB 255 2e-68 3D2K-A nrPDB 255 2e-68 6FD3-A nrPDB 253 7e-68 3E3P-A nrPDB 253 7e-68 2QNJ-A nrPDB 253 9e-68 4NIF-A nrPDB 252 1e-67 4REW-A nrPDB 252 1e-67 5Y86-A nrPDB 252 2e-67 5XZW-A nrPDB 252 2e-67 3H4J-B nrPDB 251 2e-67 5KZ7-A nrPDB 251 2e-67 3PG1-A nrPDB 251 3e-67 2JAM-A nrPDB 251 3e-67 4QMW-A nrPDB 250 7e-67 2YCR-A nrPDB 250 7e-67 4JG6-A nrPDB 249 9e-67 2JDO-A nrPDB 249 2e-66 3EB0-A nrPDB 248 2e-66 4CZT-A nrPDB 247 4e-66 4CFF-A nrPDB 247 5e-66 4L42-A nrPDB 247 5e-66 4CFH-A nrPDB 247 5e-66 5KCV-A nrPDB 247 6e-66 5WAX-A nrPDB 246 7e-66 5EZV-A nrPDB 246 7e-66 4CQG-A nrPDB 246 8e-66 4RED-A nrPDB 246 8e-66 2YAB-A nrPDB 246 8e-66 5J5T-A nrPDB 246 9e-66 3I6U-A nrPDB 246 9e-66 5D7A-A nrPDB 246 9e-66 4D28-A nrPDB 246 1e-65 4D2V-A nrPDB 245 1e-65 2W4O-A nrPDB 245 1e-65 2Y7J-A nrPDB 245 2e-65 1PHK-A nrPDB 245 2e-65 5D9K-A nrPDB 245 2e-65 4RLP-A nrPDB 245 2e-65 3MV5-A nrPDB 245 2e-65 3GUB-A nrPDB 244 3e-65 2J90-A nrPDB 244 3e-65 2A27-A nrPDB 244 4e-65 2XIK-A nrPDB 243 5e-65 2I6L-A nrPDB 243 6e-65 4JXF-A nrPDB 243 6e-65 1ZWS-A nrPDB 243 6e-65 5ZTN-A nrPDB 243 7e-65 3F3Z-A nrPDB 243 7e-65 4FZF-B nrPDB 243 7e-65 4KS7-A nrPDB 242 1e-64 2UV2-A nrPDB 242 1e-64 3TXO-A nrPDB 242 1e-64 5F9E-A nrPDB 242 2e-64 3Q53-A nrPDB 241 2e-64 3DAK-A nrPDB 241 3e-64 4PDS-A nrPDB 240 4e-64 2HAK-A nrPDB 240 5e-64 4FIE-A nrPDB 240 5e-64 6C9D-A nrPDB 240 5e-64 2YZA-A nrPDB 240 6e-64 1FOT-A nrPDB 240 8e-64 5DBX-A nrPDB 239 9e-64 3TKU-A nrPDB 239 1e-63 2F57-A nrPDB 239 1e-63 4RA4-A nrPDB 238 2e-63 5JZN-A nrPDB 238 2e-63 2Z7Q-A nrPDB 238 2e-63 4AW2-A nrPDB 238 3e-63 4JDH-A nrPDB 238 3e-63 3IS5-A nrPDB 237 4e-63 2Q0N-A nrPDB 237 5e-63 3ZUT-A nrPDB 237 5e-63 4XBR-A nrPDB 236 7e-63 3HDN-A nrPDB 236 7e-63 3UC3-A nrPDB 236 9e-63 6ED6-A nrPDB 235 1e-62 6HXF-B nrPDB 235 1e-62 2HW6-A nrPDB 235 2e-62 3UDB-A nrPDB 235 2e-62 6E9W-A nrPDB 234 3e-62 5LOH-A nrPDB 234 3e-62 3DB8-A nrPDB 233 5e-62 6FDY-U nrPDB 233 7e-62 4CSV-A nrPDB 233 9e-62 2X4F-A nrPDB 232 1e-61 4U41-A nrPDB 232 1e-61 6CMJ-A nrPDB 231 3e-61 1VZO-A nrPDB 231 3e-61 3UTO-A nrPDB 231 3e-61 5X3F-B nrPDB 231 3e-61 5N23-A nrPDB 230 5e-61 4WB7-A nrPDB 229 9e-61 3A8W-A nrPDB 229 1e-60 1KOA-A nrPDB 228 1e-60 3ORZ-A nrPDB 228 2e-60 3PFQ-A nrPDB 228 2e-60 1U5R-A nrPDB 228 2e-60 2OU7-A nrPDB 228 2e-60 4YNZ-A nrPDB 228 3e-60 4APC-A nrPDB 227 3e-60 4B6L-A nrPDB 227 4e-60 2GCD-A nrPDB 227 6e-60 4J52-A nrPDB 226 9e-60 3ALO-A nrPDB 226 9e-60 2WO6-A nrPDB 226 1e-59 4CRL-A nrPDB 225 1e-59 2I0E-A nrPDB 225 2e-59 5YV8-A nrPDB 225 2e-59 2VD5-A nrPDB 225 2e-59 3LM0-A nrPDB 225 2e-59 6CKI-A nrPDB 224 3e-59 4B8L-A nrPDB 224 4e-59 4C0T-A nrPDB 224 4e-59 4I6B-A nrPDB 223 7e-59 5DYK-A nrPDB 223 7e-59 3KN6-A nrPDB 223 7e-59 5KKR-C nrPDB 223 9e-59 3VN9-A nrPDB 223 1e-58 2BRG-A nrPDB 223 1e-58 5X8I-B nrPDB 222 2e-58 3HKO-A nrPDB 222 2e-58 4AF3-A nrPDB 222 2e-58 6O6Q-A nrPDB 222 2e-58 4AN9-A nrPDB 222 2e-58 3EQC-A nrPDB 221 2e-58 6CQF-A nrPDB 221 3e-58 1KOB-A nrPDB 221 3e-58 3PPZ-A nrPDB 221 3e-58 6BDL-A nrPDB 218 2e-57 3FME-A nrPDB 218 2e-57 6FYV-A nrPDB 218 2e-57 3NYO-A nrPDB 218 3e-57 5FET-A nrPDB 217 4e-57 4MD7-E nrPDB 217 4e-57 2FO0-A nrPDB 217 4e-57 2WQN-A nrPDB 217 5e-57 4XEY-B nrPDB 217 5e-57 4TNB-A nrPDB 216 1e-56 3FXW-A nrPDB 215 1e-56 6BXI-A nrPDB 215 2e-56 2PVN-A nrPDB 215 2e-56 6HMD-A nrPDB 214 4e-56 6NPU-A nrPDB 213 7e-56 3C51-A nrPDB 213 9e-56 4WNO-A nrPDB 212 1e-55 1NY3-A nrPDB 212 2e-55 3KA0-A nrPDB 212 2e-55 2XNP-A nrPDB 212 2e-55 3TT0-A nrPDB 211 3e-55 6EII-A nrPDB 211 3e-55 2OZA-A nrPDB 211 3e-55 4FR4-A nrPDB 211 3e-55 2H8H-A nrPDB 210 4e-55 5A46-A nrPDB 210 5e-55 4UY9-A nrPDB 210 6e-55 4E93-A nrPDB 210 7e-55 4GS6-A nrPDB 210 7e-55 3DTC-A nrPDB 209 1e-54 3GQL-A nrPDB 208 2e-54 4UYA-A nrPDB 208 2e-54 2XYN-A nrPDB 208 2e-54 6GVJ-A nrPDB 208 2e-54 5XVU-A nrPDB 208 3e-54 6F3F-A nrPDB 208 3e-54 1S9I-A nrPDB 208 3e-54 6QAU-A nrPDB 207 4e-54 6E2O-A nrPDB 207 5e-54 5H2U-A nrPDB 207 5e-54 5UNP-A nrPDB 206 1e-53 5UUU-A nrPDB 205 1e-53 2PSQ-A nrPDB 205 2e-53 4AT3-A nrPDB 205 3e-53 4OTD-A nrPDB 205 3e-53 3PVW-A nrPDB 204 3e-53 4EBW-A nrPDB 204 3e-53 2DQ7-X nrPDB 204 4e-53 5MJB-A nrPDB 203 7e-53 5SYS-A nrPDB 203 9e-53 3HMP-A nrPDB 203 1e-52 3A4O-X nrPDB 202 1e-52 4P5Q-A nrPDB 202 1e-52 3RAW-A nrPDB 202 1e-52 4EQM-A nrPDB 202 1e-52 5B2L-A nrPDB 202 2e-52 2J0K-A nrPDB 202 2e-52 2WTK-C nrPDB 202 2e-52 4K33-A nrPDB 202 2e-52 4YHJ-A nrPDB 202 2e-52 3V5Q-A nrPDB 202 2e-52 4IAN-A nrPDB 201 3e-52 5EG3-A nrPDB 201 4e-52 6CCF-A nrPDB 201 4e-52 5O2B-A nrPDB 201 4e-52 5O2C-A nrPDB 201 4e-52 2ZMD-A nrPDB 200 4e-52 5X5O-A nrPDB 200 4e-52 5L6P-A nrPDB 200 5e-52 3DKO-A nrPDB 200 5e-52 5AP3-A nrPDB 200 5e-52 2R2P-A nrPDB 200 6e-52 2PL0-A nrPDB 200 7e-52 4XLV-A nrPDB 200 7e-52 1JPA-A nrPDB 200 7e-52 1LUF-A nrPDB 200 8e-52 4CRS-A nrPDB 199 1e-51 6DBN-A nrPDB 199 1e-51 4OLI-A nrPDB 199 1e-51 6GQK-A nrPDB 198 2e-51 5VO2-A nrPDB 198 2e-51 1TKI-A nrPDB 198 3e-51 3QGY-A nrPDB 197 4e-51 4PWN-A nrPDB 197 5e-51 2Y6O-A nrPDB 197 5e-51 6BSD-A nrPDB 197 6e-51 5KMM-A nrPDB 197 7e-51 6DBM-A nrPDB 197 7e-51 2VWV-A nrPDB 196 1e-50 4XCU-A nrPDB 196 1e-50 6FEX-A nrPDB 195 2e-50 4Y93-A nrPDB 195 2e-50 4KIK-B nrPDB 195 3e-50 1ZXE-A nrPDB 194 3e-50 3ORP-A nrPDB 194 4e-50 1K9A-A nrPDB 193 7e-50 6FER-A nrPDB 193 1e-49 3QA8-A nrPDB 192 1e-49 3PP0-A nrPDB 192 1e-49 2HK5-A nrPDB 192 1e-49 5TUR-A nrPDB 192 2e-49 4XI2-A nrPDB 191 2e-49 2OGV-A nrPDB 191 2e-49 1FVR-A nrPDB 191 2e-49 3KRL-A nrPDB 191 3e-49 4PDO-A nrPDB 191 3e-49 3BEA-A nrPDB 191 4e-49 3I81-A nrPDB 191 4e-49 3CJF-A nrPDB 191 4e-49 3BBT-B nrPDB 191 4e-49 3OMV-A nrPDB 191 4e-49 3SXS-A nrPDB 190 5e-49 1BYG-A nrPDB 190 5e-49 3KUL-B nrPDB 190 6e-49 4E20-A nrPDB 190 6e-49 3BGP-A nrPDB 190 7e-49 6E4F-A nrPDB 190 9e-49 3LZB-A nrPDB 189 1e-48 5TQX-A nrPDB 189 1e-48 5GNK-A nrPDB 189 1e-48 3DLS-A nrPDB 189 1e-48 4LFI-A nrPDB 189 1e-48 4RC3-A nrPDB 189 1e-48 4M7I-A nrPDB 188 2e-48 5AMN-A nrPDB 188 2e-48 5VD3-A nrPDB 188 2e-48 1AD5-A nrPDB 188 2e-48 4H1J-A nrPDB 188 2e-48 4R7H-A nrPDB 188 3e-48 4HZS-A nrPDB 188 3e-48 5UIU-A nrPDB 187 4e-48 2OZO-A nrPDB 187 4e-48 5GRN-A nrPDB 187 5e-48 1U59-A nrPDB 187 6e-48 2W1I-A nrPDB 186 7e-48 4XUF-A nrPDB 186 8e-48 3IO7-A nrPDB 186 1e-47 5X02-A nrPDB 186 1e-47 1U54-B nrPDB 186 1e-47 5HI2-A nrPDB 185 2e-47 4LRM-A nrPDB 184 3e-47 5HIE-A nrPDB 184 3e-47 4HVI-A nrPDB 184 4e-47 2X7G-A nrPDB 184 4e-47 5HVK-A nrPDB 184 4e-47 4WUA-A nrPDB 184 4e-47 5FM2-A nrPDB 184 5e-47 2JD5-A nrPDB 183 7e-47 5U6B-A nrPDB 183 9e-47 4YFF-A nrPDB 183 9e-47 5TOS-A nrPDB 183 1e-46 3ZBF-A nrPDB 183 1e-46 3M42-A nrPDB 182 1e-46 3C1X-A nrPDB 182 1e-46 2WTK-B nrPDB 182 2e-46 5HLW-A nrPDB 182 2e-46 3ZZW-A nrPDB 182 2e-46 3G0E-A nrPDB 182 2e-46 2A1A-B nrPDB 181 4e-46 4X7Q-B nrPDB 180 5e-46 4NEU-A nrPDB 180 5e-46 3LLT-A nrPDB 180 6e-46 3QUP-A nrPDB 179 1e-45 5O0Y-A nrPDB 178 2e-45 4C59-A nrPDB 178 3e-45 3AOX-A nrPDB 177 4e-45 6CTH-A nrPDB 177 4e-45 4TPT-A nrPDB 177 4e-45 3PLS-A nrPDB 176 7e-45 3Q4U-A nrPDB 176 1e-44 4FL3-A nrPDB 176 1e-44 3UIU-A nrPDB 176 1e-44 4Y83-A nrPDB 175 1e-44 6B2Q-A nrPDB 175 2e-44 4X3F-A nrPDB 175 2e-44 4OW8-A nrPDB 175 2e-44 3MDY-A nrPDB 175 2e-44 6J5U-C nrPDB 175 2e-44 4PL5-B nrPDB 175 3e-44 2RIO-A nrPDB 174 4e-44 5U6C-A nrPDB 174 5e-44 2PMN-X nrPDB 173 6e-44 6HV0-A nrPDB 172 1e-43 5C26-A nrPDB 171 3e-43 5WNL-A nrPDB 171 3e-43 5WNO-A nrPDB 170 5e-43 4F9B-A nrPDB 169 2e-42 3G2F-A nrPDB 166 7e-42 4IDT-A nrPDB 166 8e-42 3VHK-A nrPDB 166 9e-42 3UIM-A nrPDB 166 1e-41 3MY0-A nrPDB 166 1e-41 5LPZ-A nrPDB 166 1e-41 5LPV-A nrPDB 165 3e-41 3LMG-A nrPDB 165 3e-41 1PY5-A nrPDB 164 5e-41 2QKW-B nrPDB 163 1e-40 4LQP-A nrPDB 162 2e-40 5XD6-A nrPDB 161 2e-40 4JLC-A nrPDB 160 5e-40 4G3E-A nrPDB 160 6e-40 3SOC-A nrPDB 160 6e-40 2BUJ-A nrPDB 160 7e-40 4EUU-A nrPDB 160 7e-40 5AR8-A nrPDB 159 1e-39 4EUT-A nrPDB 159 1e-39 4F0G-A nrPDB 158 2e-39 2Y4I-B nrPDB 156 8e-39 6O8B-A nrPDB 156 1e-38 5TE0-A nrPDB 156 1e-38 6NT9-A nrPDB 156 1e-38 2H34-A nrPDB 155 3e-38 5CEK-A nrPDB 151 4e-37 6DC0-A nrPDB 151 4e-37 5E8V-A nrPDB 150 5e-37 6BFN-A nrPDB 150 7e-37 2QLU-A nrPDB 149 1e-36 5IKW-A nrPDB 147 6e-36 5VC6-A nrPDB 147 7e-36 3HNG-A nrPDB 146 9e-36 4M66-A nrPDB 145 2e-35 3QD2-B nrPDB 144 3e-35 5VDK-A nrPDB 144 5e-35 5L2Q-C nrPDB 141 4e-34 4L00-A nrPDB 137 4e-33 3SV0-A nrPDB 136 2e-32 4M69-B nrPDB 133 9e-32 5X1R-A nrPDB 133 1e-31 4BTK-A nrPDB 133 1e-31 4BTF-A nrPDB 132 2e-31 4NFN-A nrPDB 131 3e-31 5FQD-C nrPDB 131 4e-31 5J0A-A nrPDB 131 4e-31 4RT7-A nrPDB 129 1e-30 4TN6-A nrPDB 129 2e-30 2CHL-A nrPDB 129 2e-30 4JRN-A nrPDB 126 1e-29 2CMW-A nrPDB 126 1e-29 2C47-A nrPDB 125 2e-29 5USZ-A nrPDB 124 3e-29 5X18-A nrPDB 124 3e-29 4I94-A nrPDB 123 9e-29 2PZI-A nrPDB 121 5e-28 4Y12-A nrPDB 120 6e-28 4NT4-A nrPDB 119 2e-27 5M07-A nrPDB 119 2e-27 1CSN-A nrPDB 114 3e-26 4XHH-A nrPDB 114 5e-26 4XHL-A nrPDB 113 7e-26 4IX6-A nrPDB 97 9e-21 4O1O-A nrPDB 80 1e-15 4OAU-C nrPDB 76 2e-14 Sequences not found previously or not previously below threshold: 4MWI-A nrPDB 127 5e-30 5C01-A nrPDB 112 2e-25 4WOV-A nrPDB 111 4e-25 3REP-A nrPDB 110 6e-25 4L68-A nrPDB 109 2e-24 5OAT-A nrPDB 100 9e-22 5UV4-A nrPDB 97 8e-21 6J6I-B nrPDB 96 1e-20 6EQI-C nrPDB 94 7e-20 5UU1-A nrPDB 85 4e-17 5CLR-A nrPDB 83 1e-16 4CI6-B nrPDB 75 4e-14 2RSV-A nrPDB 73 1e-13 6G4J-A nrPDB 73 2e-13 2LAV-A nrPDB 72 3e-13 6EAS-A nrPDB 70 9e-13 5DMZ-A nrPDB 69 1e-12 2JII-A nrPDB 62 3e-10 5GZA-A nrPDB 61 7e-10 6M7Z-A nrPDB 60 9e-10 4CYJ-A nrPDB 58 6e-09 5GZ9-A nrPDB 57 8e-09 6EWX-A nrPDB 53 2e-07 4AZW-A nrPDB 53 2e-07 4AZV-A nrPDB 52 3e-07 4BWP-A nrPDB 52 4e-07 3Q60-A nrPDB 51 8e-07 3ENH-A nrPDB 50 1e-06 3BYV-A nrPDB 50 1e-06 4WWA-A nrPDB 49 2e-06 5VE6-A nrPDB 48 6e-06 6G38-A nrPDB 47 8e-06 3DZO-A nrPDB 46 2e-05 6BHC-A nrPDB 46 2e-05 4CZY-B nrPDB 44 8e-05 2W1Z-A nrPDB 44 9e-05 1TQM-A nrPDB 41 4e-04 5YK0-A nrPDB 39 0.003 6FAI-l nrPDB 34 0.070 6DFL-A nrPDB 34 0.093 6G18-v nrPDB 33 0.12 4FDJ-A nrPDB 33 0.12 6FDN-A nrPDB 32 0.31 3F7W-A nrPDB 30 1.4 6EF6-A nrPDB 30 1.5 2HZ7-A nrPDB 29 1.7 4GYG-A nrPDB 29 2.2 >6GU6-A nrPDB Length = 302 Score = 423 bits (1089), Expect = e-119, Method: Composition-based stats. Identities = 297/297 (100%), Positives = 297/297 (100%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH Sbjct: 6 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 65 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH Sbjct: 66 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 125 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR Sbjct: 126 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 185 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT Sbjct: 186 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 245 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM Sbjct: 246 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 302 >2BPM-A nrPDB Length = 309 Score = 380 bits (976), Expect = e-106, Method: Composition-based stats. Identities = 194/297 (65%), Positives = 235/297 (79%), Gaps = 1/297 (0%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ME++ K+EKIGEGTYGVVYK R+K TG+VVA+KKIRL++E EGVPSTAIREISLLKEL H Sbjct: 6 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 65 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNIV L DV+ +++LYL+FEFL DLKK++D+ + L+KSYL+Q+LQG+ FCH Sbjct: 66 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDA-SALTGIPLPLIKSYLFQLLQGLAFCH 124 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 S RVLHRDLKPQNLLI+ +G IKLADFGLARAFG+P+R YTHEVVTLWYR+PE+LLG Sbjct: 125 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY 184 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 YST VDIWS+G IFAE+ T++ LF GDSEIDQLFRIFR LGTP+ VWP V S+ DYK + Sbjct: 185 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 244 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 FPKW + V LDE+G LLS+ML YDP KRIS K AL HP+F D+ + + Sbjct: 245 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 301 >3NIZ-A nrPDB Length = 311 Score = 346 bits (889), Expect = 6e-96, Method: Composition-based stats. Identities = 178/295 (60%), Positives = 223/295 (75%), Gaps = 4/295 (1%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ME Y K+EK+GEGTYGVVYK + + G++VA+K+IRL++E+EG+PSTAIREISLLKEL H Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKD-SQGRIVALKRIRLDAEDEGIPSTAIREISLLKELHH 78 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNIVSL DV+ + L L+FEF+ DLKK LD G + S +K YLYQ+L+G+ CH Sbjct: 79 PNIVSLIDVIHSERCLTLVFEFMEKDLKKVLDENKTG--LQDSQIKIYLYQLLRGVAHCH 136 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 R+LHRDLKPQNLLI+ G +KLADFGLARAFGIP+R YTHEVVTLWYR+P+VL+GS + Sbjct: 137 QHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSKK 196 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 239 YST VDIWSIG IFAE+ T KPLF G ++ DQL +IF LGTPN WP+V+ L +K Sbjct: 197 YSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQR 256 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294 TF ++ +S + + G+DLLS ML +DP KRIS + A+NHPYF DLD QI Sbjct: 257 TFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDLDPQI 311 >1V0B-A nrPDB Length = 288 Score = 344 bits (883), Expect = 3e-95, Method: Composition-based stats. Identities = 175/289 (60%), Positives = 213/289 (73%), Gaps = 3/289 (1%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ME Y +EKIGEGTYGVVYK ++ G+ A+KKIRLE E+EG+PST IREIS+LKEL+H Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEGIPSTTIREISILKELKH 59 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 NIV L DV+ RL L+FE L DLKK LD G ++S KS+L Q+L GI +CH Sbjct: 60 SNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGG--LESVTAKSFLLQLLNGIAYCH 117 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 RRVLHRDLKPQNLLI+ +G +K+ADFGLARAFGIP+R YTHEVVTLWYR+P+VL+GS + Sbjct: 118 DRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKK 177 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 YST +DIWS+G IFAE+ PLF G SE DQL RIFR LGTPN++ WP V L Y Sbjct: 178 YSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPN 237 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 F ++P S +K LDE+G+DLLSKML DP +RI+ K AL H YF + Sbjct: 238 FTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >4AU8-A nrPDB Length = 296 Score = 336 bits (862), Expect = 8e-93, Method: Composition-based stats. Identities = 164/293 (55%), Positives = 208/293 (70%), Gaps = 3/293 (1%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + Y K+EKIGEGTYG V+K +++ T ++VA+K++RL+ ++EGVPS+A+REI LLKEL+H Sbjct: 6 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 65 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L DVL D +L L+FEF DLKKY DS +D +VKS+L+Q+L+G+ FCHS Sbjct: 66 NIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCN--GDLDPEIVKSFLFQLLKGLGFCHS 123 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 R VLHRDLKPQNLLI+ G +KLADFGLARAFGIP+R Y+ EVVTLWYR P+VL G+ Y Sbjct: 124 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 183 Query: 182 STPVDIWSIGTIFAELA-TKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 ST +D+WS G IFAELA +PLF G+ DQL RIFR LGTP E WP + L DYK Sbjct: 184 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 243 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 SL + V L+ G DLL +L +P +RIS + AL HPYF+D Sbjct: 244 PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 296 >4KRC-A nrPDB Length = 317 Score = 328 bits (842), Expect = 2e-90, Method: Composition-based stats. Identities = 151/295 (51%), Positives = 206/295 (69%), Gaps = 9/295 (3%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 + ++EK+G GTY VYKG +KTTG VA+K+++L+S EEG PSTAIREISL+KEL+H N Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDS-EEGTPSTAIREISLMKELKHEN 64 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPG---QYMDSSLVKSYLYQILQGIVFC 119 IV L DV+ +++L L+FEF+ DLKKY+DS G + ++ +LVK + +Q+LQG+ FC Sbjct: 65 IVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFC 124 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 H ++LHRDLKPQNLLI+ +G +KL DFGLARAFGIP+ ++ EVVTLWYR+P+VL+GS Sbjct: 125 HENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSR 184 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 YST +DIWS G I AE+ T KPLF G ++ +QL IF +GTPN +WP V L Y Sbjct: 185 TYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPKYNP 244 Query: 240 TFPKWKPGSLASHV-----KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 + P L + + LD N +D L +L +P R+S K AL+HP+F + Sbjct: 245 NIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 >5G6V-A nrPDB Length = 324 Score = 316 bits (809), Expect = 1e-86, Method: Composition-based stats. Identities = 155/298 (52%), Positives = 215/298 (72%), Gaps = 4/298 (1%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ME Y K++K+GEGTY VYKG+ K T +VA+K+IRLE EEG P TAIRE+SLLK+L+H Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEH-EEGAPCTAIREVSLLKDLKH 59 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 NIV+L D++ + L L+FE+L DLK+YLD G ++ VK +L+Q+L+G+ +CH Sbjct: 60 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDC--GNIINMHNVKLFLFQLLRGLAYCH 117 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 ++VLHRDLKPQNLLI+++G +KLADFGLARA IP + Y +EVVTLWYR P++LLGS Sbjct: 118 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTD 177 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK-N 239 YST +D+W +G IF E+AT +PLF G + +QL IFR LGTP E WP + S +++K Sbjct: 178 YSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTY 237 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 +PK++ +L SH LD +G DLL+K+L ++ RIS + A+ HP+F L +I K+ Sbjct: 238 NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKL 295 >3GC0-A nrPDB Length = 329 Score = 313 bits (802), Expect = 7e-86, Method: Composition-based stats. Identities = 169/297 (56%), Positives = 215/297 (72%), Gaps = 9/297 (3%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++ Y +I K+GEGTYG VYK T + VA+K+IRLE EEEGVP TAIRE+SLLKEL+H Sbjct: 33 IDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKELQH 92 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 NI+ L+ V+ + RL+LIFE+ DLKKY+D P + ++KS+LYQ++ G+ FCH Sbjct: 93 RNIIELKSVIHHNHRLHLIFEYAENDLKKYMDKNPD---VSMRVIKSFLYQLINGVNFCH 149 Query: 121 SRRVLHRDLKPQNLLID-----DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 SRR LHRDLKPQNLL+ + +K+ DFGLARAFGIPIR +THE++TLWYR PE+L Sbjct: 150 SRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEIL 209 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 LGS YST VDIWSI I+AE+ K PLF GDSEIDQLF+IF LG P++ WP V +L Sbjct: 210 LGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGVTALP 269 Query: 236 DYKNTFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 D+K +FPK++ +L + LD+ GLDLL+ ML DP KRIS K AL HPYF+ D Sbjct: 270 DWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFSHND 326 >1UA2-A nrPDB Length = 346 Score = 308 bits (789), Expect = 2e-84, Method: Composition-based stats. Identities = 127/291 (43%), Positives = 182/291 (62%), Gaps = 6/291 (2%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRL---ESEEEGVPSTAIREISLLKEL 58 + Y K++ +GEG + VYK R K T Q+VA+KKI+L ++G+ TA+REI LL+EL Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 HPNI+ L D S + L+F+F+ DL+ + + S +K+Y+ LQG+ + Sbjct: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKD--NSLVLTPSHIKAYMLMTLQGLEY 127 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 H +LHRDLKP NLL+D+ G +KLADFGLA++FG P R YTH+VVT WYR+PE+L G+ Sbjct: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y VD+W++G I AEL + P GDS++DQL RIF LGTP E WP++ SL DY Sbjct: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV 247 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 TF + L ++ LDL+ + +++P RI+ AL YF++ Sbjct: 248 -TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 >5EFQ-A nrPDB Length = 347 Score = 302 bits (774), Expect = 1e-82, Method: Composition-based stats. Identities = 122/303 (40%), Positives = 187/303 (61%), Gaps = 14/303 (4%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++ + I IGEGTYG VYK R K TG++VA+KK+RL++E+EG P TAIREI +L++L H Sbjct: 10 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 69 Query: 61 PNIVSLQDVLMQDSR----------LYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLY 110 +I+++++++ YL+FE++ DL L+S + + + +KS++ Sbjct: 70 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLES--GLVHFNENHIKSFMR 127 Query: 111 QILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG-IPIRVYTHEVVTLWY 169 Q+++G+ +CH + LHRD+K N+L++++G IKLADFGLAR + R YT++V+TLWY Sbjct: 128 QLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWY 187 Query: 170 RSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 R PE+LLG RY+ +D+WS G I EL TKKP+F + E+ QL I R G+P VWP Sbjct: 188 RPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWP 247 Query: 230 EVESLQDYKNTFPKWK-PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 +V L + PK + L + LDL ML DP+KR + + AL + Sbjct: 248 DVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLR 307 Query: 289 DLD 291 D++ Sbjct: 308 DVE 310 >1G3N-A nrPDB Length = 326 Score = 301 bits (771), Expect = 3e-82, Method: Composition-based stats. Identities = 137/299 (45%), Positives = 193/299 (64%), Gaps = 14/299 (4%) Query: 2 EDYTKIEKIGEGTYGVVYKGRH-KTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR- 59 + Y + +IGEG YG V+K R K G+ VA+K++R+++ EEG+P + IRE+++L+ L Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 60 --HPNIVSLQDVLM-----QDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQI 112 HPN+V L DV ++++L L+FE + DL YLD +P +K ++Q+ Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE-TIKDMMFQL 129 Query: 113 LQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSP 172 L+G+ F HS RV+HRDLKPQN+L+ G IKLADFGLAR + + T VVTLWYR+P Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAP 188 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 EVLL S+ Y+TPVD+WS+G IFAE+ +KPLF G S++DQL +I +G P E WP Sbjct: 189 EVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDV 247 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 +L + F + V ++DE G DLL K L ++PAKRIS AL+HPYF DL+ Sbjct: 248 ALP--RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLE 304 >4NST-A nrPDB Length = 351 Score = 300 bits (769), Expect = 4e-82, Method: Composition-based stats. Identities = 123/309 (39%), Positives = 187/309 (60%), Gaps = 16/309 (5%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++ + I IGEGTYG VYK + K TG++VA+KK+RL++E+EG P TAIREI +L++L H Sbjct: 12 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 71 Query: 61 PNIVSLQDVLMQDSR----------LYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLY 110 ++V++++++ YL+FE++ DL L+S + +KS++ Sbjct: 72 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLES--GLVHFSEDHIKSFMK 129 Query: 111 QILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG-IPIRVYTHEVVTLWY 169 Q+++G+ +CH + LHRD+K N+L+++ G IKLADFGLAR + R YT++V+TLWY Sbjct: 130 QLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWY 189 Query: 170 RSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 R PE+LLG RY+ +D+WS G I EL TKKP+F + E+ QL I R G+P VWP Sbjct: 190 RPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWP 249 Query: 230 EVESLQDYKNTFPKWK-PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 +V L + PK + L + LDLL ML DP+KR + + L + Sbjct: 250 DVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLK 309 Query: 289 DLDNQIKKM 297 D+ ++ KM Sbjct: 310 DV--ELSKM 316 >1CM8-A nrPDB Length = 367 Score = 298 bits (764), Expect = 2e-81, Method: Composition-based stats. Identities = 108/297 (36%), Positives = 159/297 (53%), Gaps = 15/297 (5%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y ++ +G G YG V TG VA+KK+ + E A RE+ LLK +RH N+ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENV 86 Query: 64 VSLQDVLMQDSRL------YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 + L DV D L YL+ F+ DL K + + + ++ +YQ+L+G+ Sbjct: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKH----EKLGEDRIQFLVYQMLKGLR 142 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 + H+ ++HRDLKP NL +++ +K+ DFGLAR T VVT WYR+PEV+L Sbjct: 143 YIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE---MTGYVVTRWYRAPEVILN 199 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES--LQ 235 RY+ VDIWS+G I AE+ T K LF G +DQL I + GTP E ++S + Sbjct: 200 WMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAK 259 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 +Y P+ + AS + N ++LL KML+ D +R++ AL HPYF L + Sbjct: 260 NYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 >4AGU-A nrPDB Length = 311 Score = 297 bits (761), Expect = 3e-81, Method: Composition-based stats. Identities = 119/294 (40%), Positives = 169/294 (57%), Gaps = 4/294 (1%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ME Y KI KIGEG+YGVV+K R++ TGQ+VA+KK ++ + A+REI +LK+L+H Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PN+V+L +V + RL+L+FE+ + LD G + LVKS +Q LQ + FCH Sbjct: 62 PNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRG--VPEHLVKSITWQTLQAVNFCH 119 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 +HRD+KP+N+LI IKL DFG AR P Y EV T WYRSPE+L+G + Sbjct: 120 KHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQ 179 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGT--PNNEVWPEVESLQDYK 238 Y PVD+W+IG +FAEL + PL+ G S++DQL+ I + LG P ++ Sbjct: 180 YGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGV 239 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 L N+ L LL L DP +R++ + L+HPYF ++ Sbjct: 240 KIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIRE 293 >5Z33-A nrPDB Length = 425 Score = 296 bits (759), Expect = 6e-81, Method: Composition-based stats. Identities = 112/302 (37%), Positives = 164/302 (54%), Gaps = 14/302 (4%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR-H 60 E YT +++G+G YG+V + T + VA+KK+ ++ + A+REI LL+ R H Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGH 90 Query: 61 PNIVSLQDVLMQD----SRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 NI L D+ + + YL E + DL + S GQ + + +S++YQIL G+ Sbjct: 91 RNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRS---GQPLTDAHFQSFIYQILCGL 147 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR----VYTHEVVTLWYRSP 172 + HS VLHRDLKP NLL++ +K+ DFGLAR F + T V T WYR+P Sbjct: 148 KYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAP 207 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 E++L Y+ +D+WS+G I AEL +P F G +DQL +I LGTPN E + Sbjct: 208 EIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIG 267 Query: 233 S--LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 S Q+Y P + N + + LDLL +ML +DP+ RIS + AL HPY + Sbjct: 268 SPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPYLHIW 327 Query: 291 DN 292 + Sbjct: 328 HD 329 >4BBM-A nrPDB Length = 331 Score = 293 bits (751), Expect = 6e-80, Method: Composition-based stats. Identities = 118/290 (40%), Positives = 167/290 (57%), Gaps = 4/290 (1%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ME Y + +GEG+YG+V K R+K TG++VA+KK +++ V A+REI LLK+LRH Sbjct: 24 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 83 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 N+V+L +V + R YL+FEF+ + L+ P G +D +V+ YL+QI+ GI FCH Sbjct: 84 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNG--LDYQVVQKYLFQIINGIGFCH 141 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 S ++HRD+KP+N+L+ G +KL DFG AR P VY EV T WYR+PE+L+G + Sbjct: 142 SHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVK 201 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK-N 239 Y VD+W+IG + E+ +PLF GDS+IDQL+ I LG + Sbjct: 202 YGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGV 261 Query: 240 TFPKWKPGS-LASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 P+ K L L E +DL K L DP KR L+H +F Sbjct: 262 RLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 311 >4EWQ-A nrPDB Length = 383 Score = 292 bits (749), Expect = 8e-80, Method: Composition-based stats. Identities = 105/300 (35%), Positives = 156/300 (52%), Gaps = 15/300 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E Y + +G G YG V TG VA+KK+ + RE+ LLK ++H Sbjct: 45 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 104 Query: 62 NIVSLQDVL------MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 N++ L DV + + +YL+ + DL ++I Q + V+ +YQIL+G Sbjct: 105 NVIGLLDVFTPARSLEEFNDVYLVTHLMGADL----NNIVKCQKLTDDHVQFLIYQILRG 160 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 + + HS ++HRDLKP NL +++ +K+ DFGLAR T V T WYR+PE++ Sbjct: 161 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVATRWYRAPEIM 217 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV--ES 233 L Y+ VDIWS+G I AEL T + LF G IDQL I R +GTP E+ ++ ES Sbjct: 218 LNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSES 277 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 ++Y + + + A+ + +DLL KML+ D KRI+ AL H YF + Sbjct: 278 ARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDP 337 >6DTL-A nrPDB Length = 364 Score = 292 bits (747), Expect = 1e-79, Method: Composition-based stats. Identities = 107/292 (36%), Positives = 163/292 (55%), Gaps = 10/292 (3%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 I IG+G YG+V + T + VA+KKI + + +REI LL+ + H NIV++ Sbjct: 35 IMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAI 94 Query: 67 QDVLMQD-----SRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +D++ + +Y+ +E + DL + + S Q + + +LYQIL+G+ + HS Sbjct: 95 RDIIPPPLRNAFNDVYIAYELMDTDLHQIIRS---NQALSEEHCQYFLYQILRGLKYIHS 151 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 VLHRDLKP NLL++ +K+ DFGLAR T VVT WYR+PE+LL S+ Y Sbjct: 152 ANVLHRDLKPSNLLLNANCDLKICDFGLAR-VTSESDFMTEYVVTRWYRAPELLLNSSDY 210 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPN-NEVWPEVESLQDYKNT 240 + +D+WS+G IF EL +KPLF G + QL + +GTP+ E+ E+ + Y Sbjct: 211 TAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 270 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 P + S+ + +DL+ KML +DP +RI+ AL HPY N L + Sbjct: 271 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHD 322 >2F9G-A nrPDB Length = 353 Score = 291 bits (745), Expect = 2e-79, Method: Composition-based stats. Identities = 108/309 (34%), Positives = 163/309 (52%), Gaps = 23/309 (7%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D+ +GEG YGVV HK TG++VA+KKI ++ +REI +LK +H N Sbjct: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHEN 70 Query: 63 IVSLQ-----DVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 I+++ D + +Y+I E + DL + + + Q + ++ ++YQ L+ + Sbjct: 71 IITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIST----QMLSDDHIQYFIYQTLRAVK 126 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP----------IRVYTHEVVTL 167 H V+HRDLKP NLLI+ +K+ DFGLAR T V T Sbjct: 127 VLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATR 186 Query: 168 WYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEV 227 WYR+PEV+L SA+YS +D+WS G I AEL ++P+F G QL IF +GTP+++ Sbjct: 187 WYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDN 246 Query: 228 ---WPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNH 284 E ++Y + P + L ++ G+DLL +ML++DPAKRI+ K AL H Sbjct: 247 DLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH 306 Query: 285 PYFNDLDNQ 293 PY + Sbjct: 307 PYLQTYHDP 315 >3OHT-A nrPDB Length = 389 Score = 290 bits (743), Expect = 5e-79, Method: Composition-based stats. Identities = 104/300 (34%), Positives = 156/300 (52%), Gaps = 15/300 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E Y + +G G YG V +G +A+KK+ + RE+ LLK ++H Sbjct: 51 ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 110 Query: 62 NIVSLQDVL------MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 N++ L DV + + +YL+ + DL ++I Q + V+ +YQIL+G Sbjct: 111 NVIGLLDVFTPATSLEEFNDVYLVTHLMGADL----NNIVKCQKLTDDHVQFLIYQILRG 166 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 + + HS ++HRDLKP NL +++ +K+ DFGLAR T V T WYR+PE++ Sbjct: 167 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE---MTGYVATRWYRAPEIM 223 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES-- 233 L Y+ VDIWS+G I AEL T + LF G I+QL +I R GTP V + S Sbjct: 224 LNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSHE 283 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 ++Y N+ P+ + A + +DLL KML+ D KRI+ AL HPYF+ + Sbjct: 284 ARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQYHDP 343 >4MYG-A nrPDB Length = 372 Score = 290 bits (742), Expect = 5e-79, Method: Composition-based stats. Identities = 103/295 (34%), Positives = 152/295 (51%), Gaps = 16/295 (5%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 +G G YG V K +G+ VA+KK+ + E A RE+ LLK ++H N++ L DV Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQHENVIGLLDV 110 Query: 70 LMQDSRL------YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 S L YL+ F+ DL+K + G ++ +YQ+L+G+ + HS Sbjct: 111 FTPASSLRNFYDFYLVMPFMQTDLQKIM-----GMEFSEEKIQYLVYQMLKGLKYIHSAG 165 Query: 124 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYST 183 V+HRDLKP NL +++ +K+ DFGLAR T VVT WYR+PEV+L Y+ Sbjct: 166 VVHRDLKPGNLAVNEDCELKILDFGLARHADAE---MTGYVVTRWYRAPEVILSWMHYNQ 222 Query: 184 PVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV--ESLQDYKNTF 241 VDIWS+G I AE+ T K LF G +DQL +I + G P E ++ ++ + Y + Sbjct: 223 TVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSL 282 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKK 296 P+ DLL KML D KR++ AL HP+F + ++ Sbjct: 283 PQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEE 337 >4IC8-A nrPDB Length = 442 Score = 287 bits (736), Expect = 3e-78, Method: Composition-based stats. Identities = 103/304 (33%), Positives = 164/304 (53%), Gaps = 15/304 (4%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++Y IE IG G YGVV R + TGQ VA+KKI + +RE+ +LK +H Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 114 Query: 62 NIVSLQDV------LMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 NI++++D+ + +Y++ + + DL + + S P + V+ +LYQ+L+G Sbjct: 115 NIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQP---LTLEHVRYFLYQLLRG 171 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG----IPIRVYTHEVVTLWYRS 171 + + HS +V+HRDLKP NLL+++ +K+ DFG+AR T V T WYR+ Sbjct: 172 LKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 231 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PE++L Y+ +D+WS+G IF E+ ++ LF G + + QL I LGTP+ V V Sbjct: 232 PELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAV 291 Query: 232 --ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 E ++ Y + P +P + D L LL +ML ++P+ RIS AL HP+ Sbjct: 292 GAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAK 351 Query: 290 LDNQ 293 + Sbjct: 352 YHDP 355 >3NCG-A nrPDB Length = 486 Score = 286 bits (733), Expect = 6e-78, Method: Composition-based stats. Identities = 86/299 (28%), Positives = 140/299 (46%), Gaps = 33/299 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E Y + +G+G++G V K + + T Q A+K I S + ST +RE+ LLK+L HP Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NI+ L ++L S Y++ E + + D I + + Q+ GI + H Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGG--ELFDEIIKRKRFSEHDAARIIKQVFSGITYMHK 139 Query: 122 RRVLHRDLKPQNLLIDD---KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 ++HRDLKP+N+L++ IK+ DFGL+ F + + T +Y +PEVL G+ Sbjct: 140 HNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTK-MKDRIGTAYYIAPEVLRGT 198 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y D+WS G I L + P F+G +E D L R+ Y Sbjct: 199 --YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV----------------ETGKYA 240 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 P+W+ + ++ DL+ KML + P+ RI+ L HP+ ++ + Sbjct: 241 FDLPQWR---------TISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSETPTI 290 >4QTB-A nrPDB Length = 380 Score = 286 bits (732), Expect = 9e-78, Method: Composition-based stats. Identities = 107/301 (35%), Positives = 162/301 (53%), Gaps = 15/301 (4%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 YT+++ IGEG YG+V VA+KKI E + +REI +L RH N Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHEN 100 Query: 63 IVSLQDVLMQDS-----RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 ++ ++D+L + +Y++ + + DL K L S Q + + + +LYQIL+G+ Sbjct: 101 VIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKS----QQLSNDHICYFLYQILRGLK 156 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV---YTHEVVTLWYRSPEV 174 + HS VLHRDLKP NLLI+ +K+ DFGLAR T V T WYR+PE+ Sbjct: 157 YIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEI 216 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 +L S Y+ +DIWS+G I AE+ + +P+F G +DQL I LG+P+ E + ++ Sbjct: 217 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINM 276 Query: 235 Q--DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 + +Y + P + A D LDLL +ML ++P KRI+ + AL HPY + Sbjct: 277 KARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYD 336 Query: 293 Q 293 Sbjct: 337 P 337 >2W96-B nrPDB Length = 306 Score = 285 bits (731), Expect = 1e-77, Method: Composition-based stats. Identities = 129/295 (43%), Positives = 182/295 (61%), Gaps = 13/295 (4%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR--- 59 Y + +IG G YG VYK R +G VA+K +R+ + EEG+P + +RE++LL+ L Sbjct: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFE 64 Query: 60 HPNIVSLQDVLMQDS-----RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 HPN+V L DV ++ L+FE + DL+ YLD PP + + +K + Q L+ Sbjct: 65 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG-LPAETIKDLMRQFLR 123 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 G+ F H+ ++HRDLKP+N+L+ GT+KLADFGLAR + + VVTLWYR+PEV Sbjct: 124 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALDPVVVTLWYRAPEV 182 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 LL S Y+TPVD+WS+G IFAE+ +KPLF G+SE DQL +IF +G P + WP SL Sbjct: 183 LLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 241 Query: 235 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 + FP P + S V ++E+G LL +ML ++P KRIS AL H Y + Sbjct: 242 P--RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 294 >3GC9-A nrPDB Length = 370 Score = 284 bits (727), Expect = 3e-77, Method: Composition-based stats. Identities = 101/300 (33%), Positives = 153/300 (51%), Gaps = 15/300 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + + +G G YG V Q VA+KK+ + RE+ LLK L+H Sbjct: 28 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHE 87 Query: 62 NIVSLQDVL------MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 N++ L DV S +YL+ + DL ++I Q + V+ +YQ+L+G Sbjct: 88 NVIGLLDVFTPATSIEDFSEVYLVTTLMGADL----NNIVKSQALSDEHVQFLVYQLLRG 143 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 + + HS ++HRDLKP N+ +++ +++ DFGLAR T V T WYR+PE++ Sbjct: 144 LKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEE---MTGYVATRWYRAPEIM 200 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES-- 233 L Y+ VDIWS+G I AEL K LF G IDQL RI +GTP+ EV ++ S Sbjct: 201 LNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEH 260 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 + Y + P L+S + + +DLL +ML+ D +R+S AL H YF+ + Sbjct: 261 ARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDP 320 >4ZSG-A nrPDB Length = 347 Score = 283 bits (724), Expect = 6e-77, Method: Composition-based stats. Identities = 103/304 (33%), Positives = 164/304 (53%), Gaps = 15/304 (4%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++Y IE IG G YGVV R + TGQ VA+KKI + +RE+ +LK +H Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 66 Query: 62 NIVSLQDV------LMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 NI++++D+ + +Y++ + + DL + + S P + V+ +LYQ+L+G Sbjct: 67 NIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQP---LTLEHVRYFLYQLLRG 123 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG----IPIRVYTHEVVTLWYRS 171 + + HS +V+HRDLKP NLL+++ +K+ DFG+AR T V T WYR+ Sbjct: 124 LKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 183 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PE++L Y+ +D+WS+G IF E+ ++ LF G + + QL I LGTP+ V V Sbjct: 184 PELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAV 243 Query: 232 --ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 E ++ Y + P +P + D L LL +ML ++P+ RIS AL HP+ Sbjct: 244 GAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAK 303 Query: 290 LDNQ 293 + Sbjct: 304 YHDP 307 >3DFA-A nrPDB Length = 286 Score = 283 bits (724), Expect = 8e-77, Method: Composition-based stats. Identities = 86/295 (29%), Positives = 139/295 (47%), Gaps = 33/295 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E Y + +G+G++G V K + + T Q A+K I S + ST +RE+ LLK+L HP Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NI+ L ++L S Y++ E + + D I + + Q+ GI + H Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGG--ELFDEIIKRKRFSEHDAARIIKQVFSGITYMHK 139 Query: 122 RRVLHRDLKPQNLLIDD---KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 ++HRDLKP+N+L++ IK+ DFGL+ F + + T +Y +PEVL G+ Sbjct: 140 HNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTK-MKDRIGTAYYIAPEVLRGT 198 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y D+WS G I L + P F+G +E D L R+ Y Sbjct: 199 --YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRV----------------ETGKYA 240 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 P+W+ + ++ DL+ KML + P+ RI+ L HP+ ++ Sbjct: 241 FDLPQWR---------TISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSE 286 >3OZ6-A nrPDB Length = 388 Score = 282 bits (723), Expect = 9e-77, Method: Composition-based stats. Identities = 111/335 (33%), Positives = 178/335 (53%), Gaps = 46/335 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-R 59 + Y ++K+G+G YG+V+K + TG+VVA+KKI + REI +L EL Sbjct: 8 LRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSG 67 Query: 60 HPNIVSLQDVLMQDSR--LYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 H NIV+L +VL D+ +YL+F+++ DL + + ++ + +YQ+++ I Sbjct: 68 HENIVNLLNVLRADNDRDVYLVFDYMETDLHAVIRA----NILEPVHKQYVVYQLIKVIK 123 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF---------------------GIP 156 + HS +LHRD+KP N+L++ + +K+ADFGL+R+F Sbjct: 124 YLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDD 183 Query: 157 IRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRI 216 + T V T WYR+PE+LLGS +Y+ +D+WS+G I E+ KP+F G S ++QL RI Sbjct: 184 QPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLERI 243 Query: 217 FRALGTPNNEVWPEVESL-----------------QDYKNTFPKWKPGSLASHVK-NLDE 258 + P+NE ++S + ++ F KWK L + K + +E Sbjct: 244 IGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNE 303 Query: 259 NGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 LDLL K+L ++P KRIS AL HP+ + N Sbjct: 304 EALDLLDKLLQFNPNKRISANDALKHPFVSIFHNP 338 >5NGU-A nrPDB Length = 381 Score = 282 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 108/301 (35%), Positives = 158/301 (52%), Gaps = 15/301 (4%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 YT + IGEG YG+V VA+KKI E + +REI +L RH N Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHEN 101 Query: 63 IVSLQDVL-----MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 I+ + D++ Q +Y++ + + DL K L + Q++ + + +LYQIL+G+ Sbjct: 102 IIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKT----QHLSNDHICYFLYQILRGLK 157 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV---YTHEVVTLWYRSPEV 174 + HS VLHRDLKP NLL++ +K+ DFGLAR T V T WYR+PE+ Sbjct: 158 YIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEI 217 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 +L S Y+ +DIWS+G I AE+ + +P+F G +DQL I LG+P+ E + +L Sbjct: 218 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINL 277 Query: 235 Q--DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 + +Y + P N D LDLL KML ++P KRI + AL HPY + Sbjct: 278 KARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYD 337 Query: 293 Q 293 Sbjct: 338 P 338 >3MIA-A nrPDB Length = 351 Score = 282 bits (721), Expect = 1e-76, Method: Composition-based stats. Identities = 120/302 (39%), Positives = 177/302 (58%), Gaps = 17/302 (5%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 Y K+ KIG+GT+G V+K RH+ TGQ VA+KK+ +E+E+EG P TA+REI +L+ L+H N Sbjct: 18 KYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77 Query: 63 IVSLQDVLMQ--------DSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 +V+L ++ +YL+F+F DL L ++ + +K + +L Sbjct: 78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRVMQMLLN 135 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF----GIPIRVYTHEVVTLWYR 170 G+ + H ++LHRD+K N+LI G +KLADFGLARAF YT+ VVTLWYR Sbjct: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195 Query: 171 SPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPE 230 PE+LLG Y P+D+W G I AE+ T+ P+ G++E QL I + G+ EVWP Sbjct: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255 Query: 231 VESLQDYKN-TFPKWKPGSLASHVKNL--DENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 V++ + Y+ K + + +K D LDL+ K+L+ DPA+RI ALNH +F Sbjct: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 Query: 288 ND 289 Sbjct: 316 WS 317 >5JN2-A nrPDB Length = 525 Score = 282 bits (721), Expect = 2e-76, Method: Composition-based stats. Identities = 86/296 (29%), Positives = 142/296 (47%), Gaps = 34/296 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRH 60 + Y +G+G++G V + K TGQ A+K I + + +++ + +RE+ LLK+L H Sbjct: 67 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 126 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNI+ L + YL+ E + + D I + + Q+L GI + H Sbjct: 127 PNIMKLYEFFEDKGYFYLVGEVYTGG--ELFDEIISRKRFSEVDAARIIRQVLSGITYMH 184 Query: 121 SRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 +++HRDLKP+NLL++ I++ DFGL+ F + ++ T +Y +PEVL G Sbjct: 185 KNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEA-SKKMKDKIGTAYYIAPEVLHG 243 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 + Y D+WS G I L + P F+G +E D L ++ + Y Sbjct: 244 T--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKG----------------KY 285 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 P+W K + E+ DL+ KML Y P+ RIS + AL+H + + Sbjct: 286 TFELPQW---------KKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKE 332 >3LIJ-A nrPDB Length = 494 Score = 280 bits (718), Expect = 4e-76, Method: Composition-based stats. Identities = 88/295 (29%), Positives = 136/295 (46%), Gaps = 33/295 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E Y +++K+G G YG V R K T A+K IR S S + E+++LK L HP Sbjct: 37 EMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHP 96 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NI+ L D YL+ E + D I + + Q+L G+ + H Sbjct: 97 NIMKLYDFFEDKRNYYLVMECYKGG--ELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHK 154 Query: 122 RRVLHRDLKPQNLLIDD---KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 ++HRDLKP+NLL++ IK+ DFGL+ F + + T +Y +PEVL Sbjct: 155 HNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVF-ENQKKMKERLGTAYYIAPEVL--R 211 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 +Y D+WSIG I L P F G ++ + L ++ + Y Sbjct: 212 KKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKG----------------KYT 255 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 P+W KN+ E DL+ +ML +D +RIS + AL HP+ ++ ++ Sbjct: 256 FDSPEW---------KNVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEMCSK 301 >4MVF-A nrPDB Length = 506 Score = 280 bits (716), Expect = 7e-76, Method: Composition-based stats. Identities = 87/299 (29%), Positives = 143/299 (47%), Gaps = 35/299 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + Y EK+G+GTYG VYKG K T Q+ A+K+ + + + +EI ++K+L HP Sbjct: 57 DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINR--FFQEIEIMKKLDHP 114 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L + D+ +YLI E S ++ DSI + + QI I + HS Sbjct: 115 NIVKLYETYENDNYIYLIMELCSG--RELFDSIIENGSFTEKNAATIMKQIFSAIFYLHS 172 Query: 122 RRVLHRDLKPQNLLI---DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 ++HRDLKP+N L + +K+ DFGL++ G T + T +Y +P+VL G Sbjct: 173 LNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLG-TGEFTTTKAGTPYYVAPQVLDG- 230 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 +Y DIWS G I L P F+GD++ + L ++ + W Sbjct: 231 -KYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDW---------- 279 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 ++ + +L++K+L Y+P +R + + ALNHP+ + + + Sbjct: 280 ---------------GSISSDAKNLITKLLTYNPNERCTIEEALNHPWITQMTKSHEHV 323 >4QNY-A nrPDB Length = 354 Score = 278 bits (712), Expect = 2e-75, Method: Composition-based stats. Identities = 96/300 (32%), Positives = 152/300 (50%), Gaps = 12/300 (4%) Query: 2 EDYTKIEKIGEGTYGVVYKGRH-KTTGQVVAMKKIRLESEEEGV-PSTAIREISLLKELR 59 + Y IG G+YGVV + R K+ ++VAMK++ E EE + +REI LL Sbjct: 20 DRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIKLLAHFN 79 Query: 60 HPNIVSLQDVLMQDS-----RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 NI+ L+++L + Y++ + + DLK+ L S GQ + + ++ ++YQ L+ Sbjct: 80 DDNIIGLRNILTPEDPENFDHFYIVMDIMETDLKQVLRS---GQELTEAHIQFFIYQALR 136 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 + HS V+HRD+ P N+L++ +K+ DFGLA+ T V WYR+PE+ Sbjct: 137 ALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPEL 196 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES- 233 ++ YS +D+W IG I EL +PLF G ++QL +I +GTP+ E V S Sbjct: 197 VMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSS 256 Query: 234 -LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 Q Y LDLL ML+++P +RI+ A+ HP+ L + Sbjct: 257 AAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQLHD 316 >3HZT-A nrPDB Length = 467 Score = 277 bits (708), Expect = 5e-75, Method: Composition-based stats. Identities = 84/299 (28%), Positives = 134/299 (44%), Gaps = 34/299 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPS-TAIREISLLKELRH 60 + Y +++K+G G YG V + K TG A+K I+ S S + E+++LK+L H Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNI+ L + YL+ E + D I Q + Q+L G + H Sbjct: 64 PNIMKLYEFFEDKRNYYLVMEVYRGG--ELFDEIILRQKFSEVDAAVIMKQVLSGTTYLH 121 Query: 121 SRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 ++HRDLKP+NLL++ IK+ DFGL+ F + + + T +Y +PEVL Sbjct: 122 KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGK-MKERLGTAYYIAPEVL-- 178 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 +Y D+WS G I L P F G ++ + L R+ + + + W + Sbjct: 179 RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQ------- 231 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKK 296 + + L+ ML Y+P+KRIS + ALNHP+ +Q Sbjct: 232 ------------------VSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKFCSQKHT 272 >3MA6-A nrPDB Length = 298 Score = 275 bits (705), Expect = 1e-74, Method: Composition-based stats. Identities = 86/296 (29%), Positives = 142/296 (47%), Gaps = 34/296 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRH 60 + Y +G+G++G V + K TGQ A+K I + + +++ + +RE+ LLK+L H Sbjct: 32 DRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDH 91 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNI+ L + YL+ E + + D I + + Q+L GI + H Sbjct: 92 PNIMKLYEFFEDKGYFYLVGEVYTGG--ELFDEIISRKRFSEVDAARIIRQVLSGITYMH 149 Query: 121 SRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 +++HRDLKP+NLL++ I++ DFGL+ F + ++ T +Y +PEVL G Sbjct: 150 KNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEA-SKKMKDKIGTAYYIAPEVLHG 208 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 + Y D+WS G I L + P F+G +E D L ++ + Y Sbjct: 209 T--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKG----------------KY 250 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 P+W K + E+ DL+ KML Y P+ RIS + AL+H + + Sbjct: 251 TFELPQW---------KKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKE 297 >2VN9-A nrPDB Length = 301 Score = 275 bits (703), Expect = 2e-74, Method: Composition-based stats. Identities = 88/299 (29%), Positives = 134/299 (44%), Gaps = 31/299 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++Y E++G+G + VV + TGQ A K I + RE + + L+HP Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 63 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L D + ++ YL+F+ ++ + + I +Y + + QIL+ + CH Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGG--ELFEDIVAREYYSEADASHCIQQILESVNHCHL 121 Query: 122 RRVLHRDLKPQNLLIDDKGT---IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 ++HRDLKP+NLL+ K +KLADFGLA + + T Y SPEVL Sbjct: 122 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKD 181 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y PVD+W+ G I L P F D + +L++ +A Y Sbjct: 182 -PYGKPVDMWACGVILYILLVGYPPF-WDEDQHRLYQQIKAGA---------------YD 224 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 P+W + DL++KML +PAKRI+ AL HP+ M Sbjct: 225 FPSPEWD---------TVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMM 274 >3DXN-A nrPDB Length = 287 Score = 275 bits (703), Expect = 2e-74, Method: Composition-based stats. Identities = 84/296 (28%), Positives = 134/296 (45%), Gaps = 34/296 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPS-TAIREISLLKELRH 60 + Y +++K+G G YG V + K TG A+K I+ S S + E+++LK+L H Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNI+ L + YL+ E + D I Q + Q+L G + H Sbjct: 81 PNIMKLYEFFEDKRNYYLVMEVYRGG--ELFDEIILRQKFSEVDAAVIMKQVLSGTTYLH 138 Query: 121 SRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 ++HRDLKP+NLL++ IK+ DFGL+ F + + + T +Y +PEVL Sbjct: 139 KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGK-MKERLGTAYYIAPEVL-- 195 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 +Y D+WS G I L P F G ++ + L R+ + + + W + Sbjct: 196 RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQ------- 248 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 + + L+ ML Y+P+KRIS + ALNHP+ +Q Sbjct: 249 ------------------VSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKFCSQ 286 >1JNK-A nrPDB Length = 423 Score = 274 bits (702), Expect = 2e-74, Method: Composition-based stats. Identities = 108/314 (34%), Positives = 159/314 (50%), Gaps = 26/314 (8%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++ Y ++ IG G G+V + VA+KK+ + + A RE+ L+K + H Sbjct: 61 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 120 Query: 61 PNIVSLQDVLMQDSRL------YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 NI+SL +V L YL+ E + +L + + +D + LYQ+L Sbjct: 121 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-----MELDHERMSYLLYQMLC 175 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 GI HS ++HRDLKP N+++ T+K+ DFGLAR G + T VVT +YR+PEV Sbjct: 176 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEV 234 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE-S 233 +LG Y VDIWS+G I E+ K LF G IDQ ++ LGTP E +++ + Sbjct: 235 ILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 293 Query: 234 LQDYKNTFPKWKPGSL------------ASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 +++Y PK+ + + H K DLLSKML+ DPAKRIS A Sbjct: 294 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 353 Query: 282 LNHPYFNDLDNQIK 295 L HPY N + + Sbjct: 354 LQHPYINVWYDPAE 367 >4BGQ-A nrPDB Length = 304 Score = 274 bits (702), Expect = 2e-74, Method: Composition-based stats. Identities = 116/292 (39%), Positives = 169/292 (57%), Gaps = 7/292 (2%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 M + + +GEG YGVV K RHK T ++VA+KK + E E V T +RE+ +L+ L+ Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 70 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 NIV L++ + +LYL+FE++ ++ + L+ +P G + VKSY+YQ+++ I +CH Sbjct: 71 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNG--VPPEKVKSYIYQLIKAIHWCH 128 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV-YTHEVVTLWYRSPEVLLGSA 179 ++HRD+KP+NLLI +KL DFG AR Y EV T WYRSPE+LLG A Sbjct: 129 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLG-A 187 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGT-PNNEVWPEVESLQDYK 238 Y VD+WS+G I EL+ +PLF G+SEIDQLF I + LG P+ ++ + + + Sbjct: 188 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG 247 Query: 239 NTFPKWKPGSLASH--VKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 FP + L+ LDL+ +L DPA R + LNHP F Sbjct: 248 LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 299 >5AWM-A nrPDB Length = 394 Score = 274 bits (700), Expect = 4e-74, Method: Composition-based stats. Identities = 100/306 (32%), Positives = 149/306 (48%), Gaps = 27/306 (8%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 Y + IG G G+V T Q VA+KK+ + A RE L+K + H N Sbjct: 45 RYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKN 104 Query: 63 IVSLQDVL------MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 I+ L + + +YL+ E + +L + + +D + LYQ+L GI Sbjct: 105 IIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ-----MDLDHDRMSYLLYQMLCGI 159 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 HS ++HRDLKP N+++ T+K+ DFGLAR G + T VVT +YR+PEV+L Sbjct: 160 KHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTF-MMTPYVVTRYYRAPEVIL 218 Query: 177 GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE-SLQ 235 G Y+ VDIWS+G I E+ LF G IDQ +I LGTP+ ++ +++ Sbjct: 219 GMG-YTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQPTVR 277 Query: 236 DYKNTFPKWK-------------PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMAL 282 +Y P++ P + + + +LLSKML+ DP +RIS AL Sbjct: 278 NYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEAL 337 Query: 283 NHPYFN 288 H Y N Sbjct: 338 KHEYIN 343 >3E7O-A nrPDB Length = 360 Score = 273 bits (698), Expect = 7e-74, Method: Composition-based stats. Identities = 107/314 (34%), Positives = 155/314 (49%), Gaps = 26/314 (8%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++ Y +++ IG G G+V G VA+KK+ + + A RE+ LLK + H Sbjct: 21 LKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH 80 Query: 61 PNIVSLQDVLMQDSRL------YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 NI+SL +V L YL+ E + +L + + +D + LYQ+L Sbjct: 81 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH-----MELDHERMSYLLYQMLC 135 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 GI HS ++HRDLKP N+++ T+K+ DFGLAR + T VVT +YR+PEV Sbjct: 136 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNF-MMTPYVVTRYYRAPEV 194 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE-S 233 +LG Y VDIWS+G I EL +F G IDQ ++ LGTP+ E ++ + Sbjct: 195 ILGMG-YKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPT 253 Query: 234 LQDYKNT------------FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 +++Y FP W S + K DLLSKML+ DP KRIS A Sbjct: 254 VRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEA 313 Query: 282 LNHPYFNDLDNQIK 295 L HPY + + Sbjct: 314 LRHPYITVWYDPAE 327 >3FI2-A nrPDB Length = 353 Score = 272 bits (696), Expect = 1e-73, Method: Composition-based stats. Identities = 108/307 (35%), Positives = 157/307 (51%), Gaps = 26/307 (8%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++ Y ++ IG G G+V + VA+KK+ + + A RE+ L+K + H Sbjct: 23 LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 82 Query: 61 PNIVSLQDVLMQDSRL------YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 NI+SL +V L YL+ E + +L + + +D + LYQ+L Sbjct: 83 KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ-----MELDHERMSYLLYQMLC 137 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 GI HS ++HRDLKP N+++ T+K+ DFGLAR G + T VVT +YR+PEV Sbjct: 138 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMTPYVVTRYYRAPEV 196 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE-S 233 +LG Y VDIWS+G I E+ K LF G IDQ ++ LGTP E +++ + Sbjct: 197 ILGMG-YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPT 255 Query: 234 LQDYKNTFPKWKPGSL------------ASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 +++Y PK+ + + H K DLLSKML+ DPAKRIS A Sbjct: 256 VRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDA 315 Query: 282 LNHPYFN 288 L HPY N Sbjct: 316 LQHPYIN 322 >3ZDU-A nrPDB Length = 325 Score = 272 bits (696), Expect = 1e-73, Method: Composition-based stats. Identities = 106/291 (36%), Positives = 159/291 (54%), Gaps = 5/291 (1%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ME Y + K+GEG+YG V K +HK TGQ+VA+K E E+ V A+REI LK+ H Sbjct: 2 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIF-YERPEQSVNKIAMREIKFLKQFHH 60 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 N+V+L +V Q +++L+FEF+ + L G ++S ++ YL+QIL+ I + H Sbjct: 61 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHG--LESKRLRKYLFQILRAIDYLH 118 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 S ++HRD+KP+N+L+ G KL DFG AR P +Y EV T WYR+PE++L Sbjct: 119 SNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTS 178 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK-N 239 Y PVDIW++G + E+AT P S++D L +I +G + + + Sbjct: 179 YGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGV 238 Query: 240 TFPKWK-PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 P+ + P + L+ D++ L DPA RIS L+H YF Sbjct: 239 VLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTR 289 >2XS0-A nrPDB Length = 386 Score = 272 bits (695), Expect = 1e-73, Method: Composition-based stats. Identities = 101/307 (32%), Positives = 151/307 (49%), Gaps = 26/307 (8%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++ Y ++ IG G G+V + VA+KK+ + + A RE+ L+K + H Sbjct: 25 LKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH 84 Query: 61 PNIVSLQDVLMQDSRL------YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 NI+ L +V L Y++ E + +L + + +D + LYQ+L Sbjct: 85 KNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ-----MELDHERMSYLLYQMLC 139 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 GI HS ++HRDLKP N+++ T+K+ DFGLAR G + VVT +YR+PEV Sbjct: 140 GIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF-MMVPFVVTRYYRAPEV 198 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE-S 233 +LG Y VDIWS+G I E+ LF G IDQ ++ LGTP E +++ + Sbjct: 199 ILGMG-YKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPT 257 Query: 234 LQDYKNTFPKWKPGSLASHVKNL------------DENGLDLLSKMLIYDPAKRISGKMA 281 ++ Y PK+ S ++ DLLSKML+ D +KRIS A Sbjct: 258 VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEA 317 Query: 282 LNHPYFN 288 L HPY N Sbjct: 318 LQHPYIN 324 >5U6Y-A nrPDB Length = 461 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 88/297 (29%), Positives = 133/297 (44%), Gaps = 31/297 (10%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y E++G+G + VV + GQ A K I + RE + + L+HPNI Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 V L D + ++ YLIF+ ++ + + I +Y + + QIL+ ++ CH Sbjct: 62 VRLHDSISEEGHHYLIFDLVTGG--ELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 119 Query: 124 VLHRDLKPQNLLIDDKGT---IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 V+HRDLKP+NLL+ K +KLADFGLA + + T Y SPEVL Sbjct: 120 VVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD-P 178 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 Y PVD+W+ G I L P F D + +L++ +A Y Sbjct: 179 YGKPVDLWACGVILYILLVGYPPF-WDEDQHRLYQQIKAGA---------------YDFP 222 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 P+W + DL++KML +P+KRI+ AL HP+ + M Sbjct: 223 SPEWD---------TVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCM 270 >5FG8-A nrPDB Length = 285 Score = 271 bits (693), Expect = 3e-73, Method: Composition-based stats. Identities = 83/289 (28%), Positives = 132/289 (45%), Gaps = 31/289 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++Y E++G+G + +V + K+TG A K I + RE + ++L HP Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHP 73 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L D + +++ YL+F+ ++ + + I ++ + + QIL+ + CH Sbjct: 74 NIVRLHDSIQEENYHYLVFDLVTGG--ELFEDIVAREFYSEADASHCIQQILESVNHCHQ 131 Query: 122 RRVLHRDLKPQNLLIDDKGT---IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 V+HRDLKP+NLL+ K +KLADFGLA + + T Y SPEVL Sbjct: 132 NGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVL-KK 190 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y VDIW+ G I L P F D + +L+ +A Y Sbjct: 191 EPYGKSVDIWACGVILYILLVGYPPF-WDEDQHRLYSQIKAGA---------------YD 234 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 P+W + +L+++ML +P KRI+ AL HP+ Sbjct: 235 YPSPEWD---------TVTPEAKNLINQMLTVNPNKRITAAEALKHPWI 274 >2V7O-A nrPDB Length = 336 Score = 270 bits (691), Expect = 4e-73, Method: Composition-based stats. Identities = 87/299 (29%), Positives = 134/299 (44%), Gaps = 31/299 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +DY E++G+G + VV + KT Q A K I + RE + + L+HP Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 90 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L D + ++ YL+F+ ++ + + I +Y + ++QIL+ + H Sbjct: 91 NIVRLHDSISEEGFHYLVFDLVTGG--ELFEDIVAREYYSEADASHCIHQILESVNHIHQ 148 Query: 122 RRVLHRDLKPQNLLIDDKGT---IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 ++HRDLKP+NLL+ K +KLADFGLA + + T Y SPEVL Sbjct: 149 HDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKD 208 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y PVDIW+ G I L P F D + +L++ +A Y Sbjct: 209 -PYGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQIKAGA---------------YD 251 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 P+W + +L+++ML +PAKRI+ AL HP+ M Sbjct: 252 FPSPEWD---------TVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMM 301 >2BDW-A nrPDB Length = 362 Score = 270 bits (690), Expect = 7e-73, Method: Composition-based stats. Identities = 88/299 (29%), Positives = 136/299 (45%), Gaps = 32/299 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++Y E++G+G + VV + HKTTG A K I + RE + ++L+HP Sbjct: 29 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHP 88 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L D + ++S YL+F+ ++ + + I ++ + + QIL+ I +CHS Sbjct: 89 NIVRLHDSIQEESFHYLVFDLVTGG--ELFEDIVAREFYSEADASHCIQQILESIAYCHS 146 Query: 122 RRVLHRDLKPQNLLIDDKGT---IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 ++HR+LKP+NLL+ K +KLADFGLA + T Y SPEVL Sbjct: 147 NGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVN-DSEAWHGFAGTPGYLSPEVL-KK 204 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 YS PVDIW+ G I L P F D + +L+ +A Y Sbjct: 205 DPYSKPVDIWACGVILYILLVGYPPF-WDEDQHRLYAQIKAGA---------------YD 248 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 P+W + L+ ML +P KRI+ AL P+ + + + Sbjct: 249 YPSPEWD---------TVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERVASAI 298 >5AIR-A nrPDB Length = 430 Score = 269 bits (689), Expect = 8e-73, Method: Composition-based stats. Identities = 91/303 (30%), Positives = 159/303 (52%), Gaps = 17/303 (5%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 YT + IG G++GVVY+ + +G++VA+KK+ + + RE+ ++++L H NI Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 119 Query: 64 VSLQDVL----MQDSRLYL--IFEFLSMDLKKYLDSIPP-GQYMDSSLVKSYLYQILQGI 116 V L+ + +YL + +++ + + Q + VK Y+YQ+ + + Sbjct: 120 VRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSL 179 Query: 117 VFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 + HS + HRD+KPQNLL+D D +KL DFG A+ + + + +YR+PE++ Sbjct: 180 AYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQL-VRGEPNVSYICSRYYRAPELI 238 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 G+ Y++ +D+WS G + AEL +P+F GDS +DQL I + LGTP E E+ + Sbjct: 239 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREM-NPN 297 Query: 236 DYKNTFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294 + FP+ K + L S++L Y P R++ A H +F++L + Sbjct: 298 YTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN 357 Query: 295 KKM 297 K+ Sbjct: 358 VKL 360 >2VZ6-A nrPDB Length = 313 Score = 269 bits (688), Expect = 1e-72, Method: Composition-based stats. Identities = 88/297 (29%), Positives = 133/297 (44%), Gaps = 31/297 (10%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y E++G+G + VV + GQ A K I + RE + + L+HPNI Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 V L D + ++ YLIF+ ++ + + I +Y + + QIL+ ++ CH Sbjct: 84 VRLHDSISEEGHHYLIFDLVTGG--ELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 141 Query: 124 VLHRDLKPQNLLIDDKGT---IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 V+HRDLKP+NLL+ K +KLADFGLA + + T Y SPEVL Sbjct: 142 VVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD-P 200 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 Y PVD+W+ G I L P F D + +L++ +A Y Sbjct: 201 YGKPVDLWACGVILYILLVGYPPF-WDEDQHRLYQQIKAGA---------------YDFP 244 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 P+W + DL++KML +P+KRI+ AL HP+ + M Sbjct: 245 SPEWD---------TVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCM 292 >4E7W-A nrPDB Length = 394 Score = 268 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 97/303 (32%), Positives = 167/303 (55%), Gaps = 18/303 (5%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 YT + IG G++GVV++ + + + VA+KK+ + + RE+ +++ ++HPN+ Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN------RELQIMRIVKHPNV 94 Query: 64 VSLQDVLMQDSR------LYLIFEFLSMDLKKYLDSIPP-GQYMDSSLVKSYLYQILQGI 116 V L+ + L L+ E++ + + Q M L+K Y+YQ+L+ + Sbjct: 95 VDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSL 154 Query: 117 VFCHSRRVLHRDLKPQNLLIDD-KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 + HS + HRD+KPQNLL+D G +KL DFG A+ I + + +YR+PE++ Sbjct: 155 AYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKIL-IAGEPNVSYICSRYYRAPELI 213 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 G+ Y+T +DIWS G + AEL +PLF G+S IDQL I + LGTP+ E + + Sbjct: 214 FGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKTM-NPN 272 Query: 236 DYKNTFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294 ++ FP+ +P + + +DL+S++L Y P+ R++ AL HP+F++L Sbjct: 273 YMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFFDELRTGE 332 Query: 295 KKM 297 +M Sbjct: 333 ARM 335 >3COM-A nrPDB Length = 314 Score = 267 bits (684), Expect = 3e-72, Method: Composition-based stats. Identities = 75/288 (26%), Positives = 136/288 (47%), Gaps = 32/288 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E + +EK+GEG+YG VYK HK TGQ+VA+K++ +ES+ I+EIS++++ P Sbjct: 29 EVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESD----LQEIIKEISIMQQCDSP 84 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 ++V +++ L+++ E+ + + + + + + L L+G+ + H Sbjct: 85 HVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRL-RNKTLTEDEIATILQSTLKGLEYLHF 143 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 R +HRD+K N+L++ +G KLADFG+A + + T ++ +PEV+ Y Sbjct: 144 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-QEIGY 202 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 241 + DIWS+G E+A KP + + +F I N Sbjct: 203 NCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPT--------------------NPP 242 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 P ++ L +N D + + L+ P +R + L HP+ Sbjct: 243 PTFRKPELW------SDNFTDFVKQCLVKSPEQRATATQLLQHPFVRS 284 >4YZB-A nrPDB Length = 491 Score = 267 bits (682), Expect = 5e-72, Method: Composition-based stats. Identities = 85/295 (28%), Positives = 139/295 (47%), Gaps = 34/295 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRH 60 + Y +G+G++G V + K TGQ A+K I + + +++ ++E+ LLK+L H Sbjct: 30 DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDH 89 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNI+ L + YL+ E + + D I + + Q+L GI + H Sbjct: 90 PNIMKLYEFFEDKGYFYLVTEVYTGG--ELFDEIISRKRFSEVDAARIIRQVLSGITYMH 147 Query: 121 SRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 +++HRDLKP+NLL+++ I++ DFGL+ F + ++ T +Y +PEVL G Sbjct: 148 KNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFEST-KKMKDKIGTAYYIAPEVLHG 206 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 + Y D+WS G I L + P F+G +E D L ++ + + Sbjct: 207 T--YDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKG----------------KF 248 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 P+W K + E DL+ KML Y P RIS + AL H + D Sbjct: 249 TFDLPQW---------KKVSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDA 294 >3RP9-A nrPDB Length = 458 Score = 266 bits (681), Expect = 7e-72, Method: Composition-based stats. Identities = 111/355 (31%), Positives = 161/355 (45%), Gaps = 68/355 (19%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + Y IG G+YG V + K +VVA+KKI E+ +REI++L L H Sbjct: 53 DRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHD 112 Query: 62 NIVSLQDVLMQDS-----RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 ++V + D+++ LY++ E D KK + Y+ +K+ LY +L G+ Sbjct: 113 HVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFRTPV---YLTELHIKTLLYNLLVGV 169 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP-------------------- 156 + HS +LHRDLKP N L++ ++K+ DFGLAR P Sbjct: 170 KYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVT 229 Query: 157 -------IRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT---------- 199 R T VVT WYR+PE++L Y+ +D+WSIG IFAEL Sbjct: 230 FPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYHA 289 Query: 200 -KKPLFHGDS--------------------EIDQLFRIFRALGTPNNEVWP--EVESLQD 236 + PLF G S DQL IF LGTP+ E E E + Sbjct: 290 DRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAKR 349 Query: 237 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 Y FPK + LA + + LL +ML+++P KRI+ L HP+F ++ Sbjct: 350 YIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVR 404 >3KK8-A nrPDB Length = 284 Score = 266 bits (681), Expect = 8e-72, Method: Composition-based stats. Identities = 88/299 (29%), Positives = 136/299 (45%), Gaps = 32/299 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++Y E++G+G + VV + HKTTG A K I + RE + ++L+HP Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHP 65 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L D + ++S YL+F+ ++ + + I ++ + + QIL+ I +CHS Sbjct: 66 NIVRLHDSIQEESFHYLVFDLVTGG--ELFEDIVAREFYSEADASHCIQQILESIAYCHS 123 Query: 122 RRVLHRDLKPQNLLIDDKGT---IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 ++HR+LKP+NLL+ K +KLADFGLA + T Y SPEVL Sbjct: 124 NGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVN-DSEAWHGFAGTPGYLSPEVL-KK 181 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 YS PVDIW+ G I L P F D + +L+ +A Y Sbjct: 182 DPYSKPVDIWACGVILYILLVGYPPF-WDEDQHRLYAQIKAGA---------------YD 225 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 P+W + L+ ML +P KRI+ AL P+ + + + Sbjct: 226 YPSPEWD---------TVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERVASAI 275 >3SOA-A nrPDB Length = 444 Score = 266 bits (680), Expect = 8e-72, Method: Composition-based stats. Identities = 87/299 (29%), Positives = 134/299 (44%), Gaps = 31/299 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E+Y E++G+G + VV + GQ A I + RE + + L+HP Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHP 70 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L D + ++ YLIF+ ++ + + I +Y + + QIL+ ++ CH Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGG--ELFEDIVAREYYSEADASHCIQQILEAVLHCHQ 128 Query: 122 RRVLHRDLKPQNLLIDDKGT---IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 V+HR+LKP+NLL+ K +KLADFGLA + + T Y SPEVL Sbjct: 129 MGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKD 188 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y PVD+W+ G I L P F D + +L++ +A Y Sbjct: 189 -PYGKPVDLWACGVILYILLVGYPPF-WDEDQHRLYQQIKAGA---------------YD 231 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 P+W + DL++KML +P+KRI+ AL HP+ + M Sbjct: 232 FPSPEWD---------TVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCM 281 >3BHH-A nrPDB Length = 295 Score = 265 bits (677), Expect = 2e-71, Method: Composition-based stats. Identities = 88/299 (29%), Positives = 133/299 (44%), Gaps = 31/299 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++Y E IG+G + VV + TG A K I + RE + + L+H Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 63 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L D + ++ YL+F+ ++ + + I +Y + + QIL+ ++ CH Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGG--ELFEDIVAREYYSEADASHCIQQILEAVLHCHQ 121 Query: 122 RRVLHRDLKPQNLLIDDKGT---IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 V+HRDLKP+NLL+ K +KLADFGLA + + T Y SPEVL Sbjct: 122 MGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKE 181 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 A Y PVDIW+ G I L P F D + +L++ +A Y Sbjct: 182 A-YGKPVDIWACGVILYILLVGYPPF-WDEDQHKLYQQIKAGA---------------YD 224 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 P+W + +L+++ML +PAKRI+ AL HP+ M Sbjct: 225 FPSPEWD---------TVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMM 274 >3N9X-A nrPDB Length = 432 Score = 264 bits (675), Expect = 3e-71, Method: Composition-based stats. Identities = 108/349 (30%), Positives = 161/349 (46%), Gaps = 60/349 (17%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++Y IG G+YG VY K T + VA+KK+ E+ +REI++L L+ Sbjct: 26 DNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 85 Query: 62 NIVSLQDVLMQDS-----RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 I+ L D+++ D LY++ E DLKK + ++ +K+ LY +L G Sbjct: 86 YIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFKTPI---FLTEEHIKTILYNLLLGE 142 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV----------------- 159 F H ++HRDLKP N L++ ++K+ DFGLAR Sbjct: 143 NFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNK 202 Query: 160 -----YTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELA-----------TKKPL 203 T VVT WYR+PE++L Y+ +DIWS G IFAEL + PL Sbjct: 203 NLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPL 262 Query: 204 FHGD-----------------SEIDQLFRIFRALGTPNNEVWPEVESLQ--DYKNTFPKW 244 F G S DQL IF +GTP + + + Y FP Sbjct: 263 FPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPHR 322 Query: 245 KPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 KP +L ++ ++G++LL ML ++P KRI+ AL+HPY D+ + Sbjct: 323 KPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKDVRKK 371 >5IG1-A nrPDB Length = 344 Score = 264 bits (675), Expect = 4e-71, Method: Composition-based stats. Identities = 82/287 (28%), Positives = 129/287 (44%), Gaps = 32/287 (11%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 IG+G + V++ +K TG+V A+K I L+S + REI + L+H +IVS++ Sbjct: 23 SVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMR 82 Query: 68 DVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHR 127 +S YL+FE++S + D I ++ + + ++QIL + CHS+ ++HR Sbjct: 83 RAFRDESHFYLVFEYVSGG--ELFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHR 140 Query: 128 DLKPQNLLI---DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTP 184 DLKP+NLL+ D +K+ DFGLA Y T Y SPEV+ Y T Sbjct: 141 DLKPENLLLASKDPNAPVKITDFGLAVIMEQ-GPTYFGFAGTPGYLSPEVIR-RVPYDTA 198 Query: 185 VDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKW 244 VD+W+ G I L P F + +I Y P+W Sbjct: 199 VDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNC----------------QYDFPSPEW 242 Query: 245 KPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 + A +L+ ML +P +R + + L HP+ D Sbjct: 243 DSVTTA---------AKELIKAMLEPNPKRRPTVQELLQHPWIARRD 280 >4O2Z-A nrPDB Length = 377 Score = 263 bits (673), Expect = 5e-71, Method: Composition-based stats. Identities = 101/304 (33%), Positives = 160/304 (52%), Gaps = 22/304 (7%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 YT ++ +G G YG+ TG+ V++KK R + +REI +++ H N Sbjct: 46 KYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHEN 105 Query: 63 IVSLQDV-------LMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 ++++ ++ +Y++ + +D+ L S Q ++ S ++ ++YQIL+G Sbjct: 106 LLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRS---RQVLEESHMQYFVYQILRG 162 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 + + HS V HRDLKP NL+ + +K+ DFGL+R+ +P T V+T WYR PE+L Sbjct: 163 LKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELL 222 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPN------NEVWP 229 L + YST VDIWS+G IFAE+ +KP+F G + +DQL I + +G P E Sbjct: 223 LENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREALE 282 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 ++ L D PK PG + G+D LSKM DP+KR + L HPY Sbjct: 283 KLNELPDGSLNIPKLVPGLAGNT------EGIDFLSKMWTLDPSKRPTAADMLAHPYLAH 336 Query: 290 LDNQ 293 L ++ Sbjct: 337 LHDE 340 >4LG4-A nrPDB Length = 299 Score = 262 bits (670), Expect = 1e-70, Method: Composition-based stats. Identities = 73/288 (25%), Positives = 137/288 (47%), Gaps = 32/288 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E + +EK+GEG+YG V+K HK +GQVVA+K++ +ES+ I+EIS++++ P Sbjct: 11 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD----LQEIIKEISIMQQCDSP 66 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +V +++ L+++ E+ + + + + + + L L+G+ + H Sbjct: 67 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRL-RNKTLIEDEIATILKSTLKGLEYLHF 125 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 R +HR++K N+L++ +G KLADFG+A + + T ++ +PEV+ Y Sbjct: 126 MRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-QEIGY 184 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 241 + DIWS+G E+A KP + + +F I N Sbjct: 185 NCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPT--------------------NPP 224 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 P ++ L ++ D + K L+ +P +R + L HP+ + Sbjct: 225 PTFRKPELW------SDDFTDFVKKCLVKNPEQRATATQLLQHPFIKN 266 >4FG9-A nrPDB Length = 320 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 85/299 (28%), Positives = 139/299 (46%), Gaps = 36/299 (12%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y + +G G + V K T ++VA+K I E+ EG + EI++L +++HPNI Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEAL-EGKEGSMENEIAVLHKIKHPNI 78 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 V+L D+ LYLI + +S + D I + ++Q+L + + H Sbjct: 79 VALDDIYESGGHLYLIMQLVSGG--ELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136 Query: 124 VLHRDLKPQNLL---IDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 ++HRDLKP+NLL +D+ I ++DFGL++ P V + T Y +PEVL Sbjct: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLSK-MEDPGSVLSTACGTPGYVAPEVL-AQKP 194 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 YS VD WSIG I L P F+ +++ +I +A +Y+ Sbjct: 195 YSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKA----------------EYEFD 238 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND---LDNQIKK 296 P W ++ ++ D + ++ DP KR + + AL HP+ LD I + Sbjct: 239 SPYWD---------DISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQ 288 >3Q5I-A nrPDB Length = 504 Score = 261 bits (668), Expect = 2e-70, Method: Composition-based stats. Identities = 90/309 (29%), Positives = 135/309 (43%), Gaps = 44/309 (14%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEG-----------VPSTAIR 50 E Y K+ K+G G YG V + K A+K I+ ++G Sbjct: 36 ESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYN 95 Query: 51 EISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLY 110 EISLLK L HPNI+ L DV YL+ EF + + I D + + Sbjct: 96 EISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGG--ELFEQIINRHKFDECDAANIMK 153 Query: 111 QILQGIVFCHSRRVLHRDLKPQNLLIDDKG---TIKLADFGLARAFGIPIRVYTHEVVTL 167 QIL GI + H ++HRD+KP+N+L+++K IK+ DFGL+ F ++ + T Sbjct: 154 QILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLR-DRLGTA 212 Query: 168 WYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEV 227 +Y +PEVL +Y+ D+WS G I L P F G ++ D + ++ + Sbjct: 213 YYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKG-------- 262 Query: 228 WPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 Y F W KN+ + +L+ ML YD KR + + ALN + Sbjct: 263 --------KYYFDFNDW---------KNISDEAKELIKLMLTYDYNKRCTAEEALNSRWI 305 Query: 288 NDLDNQIKK 296 N I K Sbjct: 306 KKYANNINK 314 >2JC6-A nrPDB Length = 334 Score = 261 bits (667), Expect = 3e-70, Method: Composition-based stats. Identities = 79/296 (26%), Positives = 139/296 (46%), Gaps = 34/296 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 + E +G G + V K TG++ A+K I ++ + G S+ EI++L++++H NI Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALK-GKESSIENEIAVLRKIKHENI 82 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 V+L+D+ + LYL+ + +S + D I + + + Q+L + + H Sbjct: 83 VALEDIYESPNHLYLVMQLVSGG--ELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMG 140 Query: 124 VLHRDLKPQNLLI---DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 ++HRDLKP+NLL D++ I ++DFGL++ V + T Y +PEVL Sbjct: 141 IVHRDLKPENLLYYSQDEESKIMISDFGLSK-MEGKGDVMSTACGTPGYVAPEVL-AQKP 198 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 YS VD WSIG I L P F+ +++ +I +A +Y+ Sbjct: 199 YSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKA----------------EYEFD 242 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKK 296 P W ++ ++ D + ++ DP KR + + A HP+ D + K Sbjct: 243 SPYWD---------DISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAG-DTALNK 288 >6AO5-A nrPDB Length = 362 Score = 260 bits (664), Expect = 7e-70, Method: Composition-based stats. Identities = 73/288 (25%), Positives = 137/288 (47%), Gaps = 32/288 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E + +EK+GEG+YG V+K HK +GQVVA+K++ +ES+ I+EIS++++ P Sbjct: 10 EVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD----LQEIIKEISIMQQCDSP 65 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +V +++ L+++ E+ + + + + + + L L+G+ + H Sbjct: 66 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRL-RNKTLIEDEIATILKSTLKGLEYLHF 124 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 R +HR++K N+L++ +G KLADFG+A + + T ++ +PEV+ Y Sbjct: 125 MRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI-QEIGY 183 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 241 + DIWS+G E+A KP + + +F I N Sbjct: 184 NCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPT--------------------NPP 223 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 P ++ L ++ D + K L+ +P +R + L HP+ + Sbjct: 224 PTFRKPELW------SDDFTDFVKKCLVKNPEQRATATQLLQHPFIKN 265 >3NIE-A nrPDB Length = 429 Score = 259 bits (661), Expect = 1e-69, Method: Composition-based stats. Identities = 106/352 (30%), Positives = 159/352 (45%), Gaps = 63/352 (17%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++Y IG G+YG VY K + VA+KK+ E+ +REI++L L+ Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 87 Query: 62 NIVSLQDVLMQDS-----RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 I+ L D+++ + LY++ E DLKK + ++ VK+ LY +L G Sbjct: 88 YIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPI---FLTEQHVKTILYNLLLGE 144 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY---------------- 160 F H ++HRDLKP N L++ ++K+ DFGLAR ++ Sbjct: 145 KFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGP 204 Query: 161 ---------THEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELA-----------TK 200 T VVT WYR+PE++L Y+ +DIWS G IFAEL + Sbjct: 205 HNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNR 264 Query: 201 KPLFHGD-----------------SEIDQLFRIFRALGTPNNEVWPEV--ESLQDYKNTF 241 PLF G S DQL IF +GTP E + + + Y F Sbjct: 265 FPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLF 324 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 P L+ ++ + G+DLL ML ++ KRI+ AL+HPY D+ + Sbjct: 325 PTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKE 376 >4RGJ-A nrPDB Length = 520 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 86/292 (29%), Positives = 135/292 (46%), Gaps = 35/292 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEG-VPSTAIREISLLKELRH 60 E Y I+ +G+G++G V R K TG A+K I + + + +RE+ LLK L H Sbjct: 60 EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDH 119 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 NI+ L + ++ YL+ + + + D I + + QIL GI + H Sbjct: 120 INIMKLYEFFEDNNYYYLVSDVYTGG--ELFDEIISRKRFYEIDAARIIKQILSGITYMH 177 Query: 121 SRRVLHRDLKPQNLLI----DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 V+HRDLKP+N+L+ + IK+ DFGL+ F + ++ T +Y +P+VL Sbjct: 178 KNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHF-EYSKKMKDKIGTAYYIAPDVLH 236 Query: 177 GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 236 G+ Y DIWS G I L + P F+G +E D L ++ Sbjct: 237 GT--YDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKV----------------EAGK 278 Query: 237 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 Y P++ K + + DL+ KML+Y A RIS + AL H + Sbjct: 279 YTFDLPQF---------KKISDKAKDLIKKMLMYTSAVRISARDALEHEWIK 321 >5ES1-A nrPDB Length = 328 Score = 257 bits (657), Expect = 4e-69, Method: Composition-based stats. Identities = 78/286 (27%), Positives = 127/286 (44%), Gaps = 32/286 (11%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 +Y + IG+G + V RH TG+ VA+K I RE+ ++K L HPN Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPN 75 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 IV L +V+ + LYL+ E+ S + D + M ++ QI+ + +CH + Sbjct: 76 IVKLFEVIETEKTLYLVMEYASAG--EVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQK 133 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 ++HRDLK +NLL+D + IK+ADFG + F + ++ T + Y +PE+ G Sbjct: 134 NIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDT-FCGSPPYAAPELFQGKKYDG 192 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 VDIWS+G I L + F G + + R+ R K P Sbjct: 193 PEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRG------------------KYRVP 234 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 + S +L + L+ +PAKR + + + + N Sbjct: 235 FYMSTDCES-----------ILRRFLVLNPAKRCTLEQIMKDKWIN 269 >3TAC-A nrPDB Length = 361 Score = 256 bits (655), Expect = 8e-69, Method: Composition-based stats. Identities = 91/306 (29%), Positives = 141/306 (46%), Gaps = 36/306 (11%) Query: 1 MED-YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI---RLESEEEGVPSTAIREISLLK 56 ED Y E IG+G + VV + ++ TGQ A+K + + S RE S+ Sbjct: 24 FEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICH 83 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLSM-DL-KKYLDSIPPGQYMDSSLVKSYLYQILQ 114 L+HP+IV L + D LY++FEF+ DL + + G ++ Y+ QIL+ Sbjct: 84 MLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILE 143 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGT---IKLADFGLARAFGIPIRVYTHEVVTLWYRS 171 + +CH ++HRD+KP +L+ K +KL FG+A G V V T + + Sbjct: 144 ALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMA 203 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PEV+ Y PVD+W G I L + F+G E R+F + Sbjct: 204 PEVV-KREPYGKPVDVWGCGVILFILLSGCLPFYGTKE-----RLFEGIIK--------- 248 Query: 232 ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 YK +W ++ E+ DL+ +ML+ DPA+RI+ ALNHP+ + D Sbjct: 249 ---GKYKMNPRQW---------SHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERD 296 Query: 292 NQIKKM 297 K+ Sbjct: 297 RYAYKI 302 >3MN3-A nrPDB Length = 271 Score = 256 bits (655), Expect = 8e-69, Method: Composition-based stats. Identities = 79/287 (27%), Positives = 130/287 (45%), Gaps = 34/287 (11%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPS-TAIREISLLKELRHP 61 +Y ++ +GEG++G V H TTGQ VA+K I + + REIS L+ LRHP Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHP 64 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +I+ L DV+ + ++ E+ +L D I M + + QI+ + +CH Sbjct: 65 HIIKLYDVIKSKDEIIMVIEYAGNEL---FDYIVQRDKMSEQEARRFFQQIISAVEYCHR 121 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 +++HRDLKP+NLL+D+ +K+ADFGL+ + Y +PEV+ G Sbjct: 122 HKIVHRDLKPENLLLDEHLNVKIADFGLSNIM-TDGNFLKTSCGSPNYAAPEVISGKLYA 180 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 241 VD+WS G I + ++ F +S + +++ + T Sbjct: 181 GPEVDVWSCGVILYVMLCRRLPFDDES------------------IPVLFKNISNGVYTL 222 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 PK+ L L+ +MLI +P RIS + +F Sbjct: 223 PKF-----------LSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFK 258 >5YKS-A nrPDB Length = 377 Score = 256 bits (654), Expect = 9e-69, Method: Composition-based stats. Identities = 90/290 (31%), Positives = 137/290 (47%), Gaps = 34/290 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y + +G G + VV RH TG+ VA+K I + +E+ +K ++HPNI Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI 96 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQY-MDSSLVKSYLYQILQGIVFCHSR 122 V L +V+ ++LYLI E D D I + ++ L K Y QI+ I +CH Sbjct: 97 VRLYEVIDTQTKLYLILEL--GDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 154 Query: 123 RVLHRDLKPQNL-LIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 V+HRDLKP+N+ + +G +KL DFG + F P + T +L Y +PE+LLG Sbjct: 155 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKF-QPGKKLTTSCGSLAYSAPEILLGDEYD 213 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 241 + VDIWS+G I L +P F ++ + L I D K T Sbjct: 214 APAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIM------------------DCKYTV 255 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 P ++ + DL+++ML DP +R S + NHP+ +D Sbjct: 256 P-----------SHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVD 294 >4UZD-A nrPDB Length = 287 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 83/289 (28%), Positives = 137/289 (47%), Gaps = 35/289 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELR 59 +ED+ +G+G +G VY R K + ++A+K + + + E+ GV RE+ + LR Sbjct: 7 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR 66 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HPNI+ L +R+YLI E+ L + D +Y+ ++ + +C Sbjct: 67 HPNILRLYGYFHDATRVYLILEYAP--LGTVYRELQKLSKFDEQRTATYITELANALSYC 124 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 HS+RV+HRD+KP+NLL+ G +K+ADFG + P T TL Y PE++ G Sbjct: 125 HSKRVIHRDIKPENLLLGSAGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMIEGRM 182 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 VD+WS+G + E KP F ++ + RI R + Sbjct: 183 H-DEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRV------------------EF 223 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 TFP + + E DL+S++L ++P++R + L HP+ Sbjct: 224 TFPDF-----------VTEGARDLISRLLKHNPSQRPMLREVLEHPWIT 261 >3D2K-A nrPDB Length = 272 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 80/289 (27%), Positives = 135/289 (46%), Gaps = 35/289 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELR 59 +ED+ +G+G +G VY R + + ++A+K + + + E+ GV RE+ + LR Sbjct: 11 LEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLR 70 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HPNI+ L +R+YLI E+ L + D +Y+ ++ + +C Sbjct: 71 HPNILRLYGYFHDATRVYLILEYAP--LGTVYRELQKLSRFDEQRTATYITELANALSYC 128 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 HS+RV+HRD+KP+NLL+ G +K+ADFG + P T TL Y PE++ G Sbjct: 129 HSKRVIHRDIKPENLLLGSNGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMIEGRM 186 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 VD+WS+G + E P F + + RI R + Sbjct: 187 H-DEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRV------------------EF 227 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 TFP + + E DL+S++L ++ ++R++ L HP+ Sbjct: 228 TFPDF-----------VTEGARDLISRLLKHNASQRLTLAEVLEHPWIK 265 >6FD3-A nrPDB Length = 300 Score = 253 bits (647), Expect = 7e-68, Method: Composition-based stats. Identities = 83/296 (28%), Positives = 138/296 (46%), Gaps = 33/296 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + YT+ EKIG+G G VY TGQ VA+K++ L+ + + I EI +++E ++P Sbjct: 22 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK--KELIINEILVMRENKNP 79 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV+ D + L+++ E+L+ L + MD + + + LQ + F HS Sbjct: 80 NIVNYLDSYLVGDELWVVMEYLAGGS---LTDVVTETCMDEGQIAAVCRECLQALDFLHS 136 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 +V+HRD+K N+L+ G++KL DFG + V T ++ +PEV+ A Y Sbjct: 137 NQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-Y 195 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 241 VDIWS+G + E+ +P + ++ + L+ I GTP Sbjct: 196 GPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATN-GTPE----------------- 237 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 + + L D L++ L D +R S K L HP+ LD + + Sbjct: 238 --------LQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK-LDKPLSSL 284 >3E3P-A nrPDB Length = 360 Score = 253 bits (647), Expect = 7e-68, Method: Composition-based stats. Identities = 102/314 (32%), Positives = 162/314 (51%), Gaps = 24/314 (7%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-- 58 M+ + G+GT+G V G+ K+TG VA+KK+ + RE+ ++++L Sbjct: 22 MDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRN------RELQIMQDLAV 75 Query: 59 -RHPNIVSLQDVLMQ-------DSRLYLIFEFLSMDLKKYLDSIPPGQYMDSS-LVKSYL 109 HPNIV LQ D L ++ E++ L + + Q L+K +L Sbjct: 76 LHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKVFL 135 Query: 110 YQILQGIVFCH--SRRVLHRDLKPQNLLIDD-KGTIKLADFGLARAFGIPIRVYTHEVVT 166 +Q+++ I H S V HRD+KP N+L+++ GT+KL DFG A+ P + + Sbjct: 136 FQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLS-PSEPNVAYICS 194 Query: 167 LWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNE 226 +YR+PE++ G+ Y+T VDIWS+G IFAE+ +P+F GD+ QL I R LG P+ E Sbjct: 195 RYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGCPSRE 254 Query: 227 VWPEVE---SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 V ++ + D N+ + H + DLLS +L Y P +R+ AL Sbjct: 255 VLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPYEALC 314 Query: 284 HPYFNDLDNQIKKM 297 HPYF++L + K+ Sbjct: 315 HPYFDELHDPATKL 328 >2QNJ-A nrPDB Length = 328 Score = 253 bits (646), Expect = 9e-68, Method: Composition-based stats. Identities = 79/286 (27%), Positives = 127/286 (44%), Gaps = 32/286 (11%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 +Y ++ IG+G + V RH TG+ VA+K I RE+ ++K L HPN Sbjct: 13 NYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPN 72 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 IV L +V+ + LYLI E+ S + D + M +S QI+ + +CH + Sbjct: 73 IVKLFEVIETEKTLYLIMEYASGG--EVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQK 130 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 R++HRDLK +NLL+D IK+ADFG + F + ++ T + Y +PE+ G Sbjct: 131 RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDT-FCGSPPYAAPELFQGKKYDG 189 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 VD+WS+G I L + F G + + R+ R K P Sbjct: 190 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG------------------KYRIP 231 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 + + LL + L+ +P KR + + + + N Sbjct: 232 FYMSTDCEN-----------LLKRFLVLNPIKRGTLEQIMKDRWIN 266 >4NIF-A nrPDB Length = 333 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 80/299 (26%), Positives = 125/299 (41%), Gaps = 42/299 (14%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLL-KELRH 60 + Y E IG G+Y + HK T A+K I + EI +L + +H Sbjct: 8 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPS------EEIEILLRYGQH 61 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNI++L+DV +YL+ E + + LD I ++ L+ I + + + H Sbjct: 62 PNIITLKDVYDDGKHVYLVTELMRGG--ELLDKILRQKFFSEREASFVLHTIGKTVEYLH 119 Query: 121 SRRVLHRDLKPQNLL-IDDKGT---IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 S+ V+HRDLKP N+L +D+ G +++ DFG A+ + T + +PEVL Sbjct: 120 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 179 Query: 177 GSARYSTPVDIWSIGTIFAELATKKPLF---HGDSEIDQLFRIFRALGTPNNEVWPEVES 233 Y DIWS+G + + F D+ + L RI T + W Sbjct: 180 RQG-YDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNW----- 233 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 + E DL+SKML DP +R++ K L HP+ D Sbjct: 234 --------------------NTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDK 272 >4REW-A nrPDB Length = 540 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 85/287 (29%), Positives = 124/287 (43%), Gaps = 33/287 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE-GVPSTAIREISLLKELRHPN 62 Y + +G GT+G V G+H+ TG VA+K + + V REI LK RHP+ Sbjct: 8 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 67 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 I+ L V+ S ++++ E++S + D I +D + QIL G+ +CH Sbjct: 68 IIKLYQVISTPSDIFMVMEYVSGG--ELFDYICKNGRLDEKESRRLFQQILSGVDYCHRH 125 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 V+HRDLKP+N+L+D K+ADFGL+ + T + Y +PEV+ G Sbjct: 126 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAPEVISGRLYAG 184 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 VDIWS G I L F D +I D P Sbjct: 185 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI------------------CDGIFYTP 226 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 ++ L+ + + LL ML DP KR S K H +F Sbjct: 227 QY-----------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ 262 >5Y86-A nrPDB Length = 588 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 89/325 (27%), Positives = 154/325 (47%), Gaps = 46/325 (14%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR--- 59 Y ++ IG+G++G V + Q VA+K +R E + A EI +L+ L+ Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNE---KRFHRQAAEEIRILEHLKKQD 264 Query: 60 ---HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 N++ + + + + + FE LS+DL + + Q LV+ + ILQ + Sbjct: 265 KTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK-NKFQGFSVQLVRKFAQSILQSL 323 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGT--IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 H +++H DLKP+N+L+ G K+ DFG + + + + +YR+PE+ Sbjct: 324 DALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF---EYQKLYTYIQSRFYRAPEI 380 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 +LGS RYSTP+DIWS G I AEL T +PLF G+ E DQL + LG P ++ + + Sbjct: 381 ILGS-RYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRA 439 Query: 235 QDYKNT--FPKWKP---------------------------GSLASHVKNLDEN-GLDLL 264 + + N+ P++ + +K D+ ++ L Sbjct: 440 KYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFL 499 Query: 265 SKMLIYDPAKRISGKMALNHPYFND 289 + L +DP+ R++ AL HP+ + Sbjct: 500 KRCLHWDPSARLTPAQALRHPWISK 524 >5XZW-A nrPDB Length = 471 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 87/307 (28%), Positives = 133/307 (43%), Gaps = 44/307 (14%) Query: 1 MEDYTKI-EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR 59 +D++ I E +G+G + V K +TTG+ A+K I G RE+ +L++L Sbjct: 194 FKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKV-IGNMDGVTRELEVLQKLN 252 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HP IV L+ Y++ EF+S +D + + + QIL I + Sbjct: 253 HPRIVRLKGFYEDTESYYMVMEFVSGG--DLMDFVAAHGAVGEDAGREISRQILTAIKYI 310 Query: 120 HSRRVLHRDLKPQNLLI--DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 HS + HRDLKP N+LI DD +K+ DFGLA+ G + T TL Y +PEV+ G Sbjct: 311 HSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKT-FCGTLAYVAPEVIRG 369 Query: 178 SAR------------YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNN 225 YS+ VD+WS+G + + T F G ++ +I R Sbjct: 370 KDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGP 429 Query: 226 EVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHP 285 L+D++ + E D + +L DP R + ALNHP Sbjct: 430 --------LKDFR-----------------ISEEARDFIDSLLQVDPNNRSTAAKALNHP 464 Query: 286 YFNDLDN 292 + D N Sbjct: 465 WIVDSSN 471 >3H4J-B nrPDB Length = 336 Score = 251 bits (642), Expect = 2e-67, Method: Composition-based stats. Identities = 77/286 (26%), Positives = 127/286 (44%), Gaps = 34/286 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE-GVPSTAIREISLLKELRHPN 62 Y E +GEG++G V H T Q VA+K I + ++ + REIS LK LRHP+ Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 70 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 I+ L DV+ + + ++ E+ +L D I + M + + QI+ I +CH Sbjct: 71 IIKLYDVITTPTDIVMVIEYAGGEL---FDYIVEKKRMTEDEGRRFFQQIICAIEYCHRH 127 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 +++HRDLKP+NLL+DD +K+ADFGL+ + Y +PEV+ G Sbjct: 128 KIVHRDLKPENLLLDDNLNVKIADFGLSNIM-TDGNFLKTSCGSPNYAAPEVINGKLYAG 186 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 VD+WS G + + + F + + + + P Sbjct: 187 PEVDVWSCGIVLYVMLVGRLPFD------------------DEFIPNLFKKVNSCVYVMP 228 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 + L L+ +M++ DP +RI+ + P+FN Sbjct: 229 DF-----------LSPGAQSLIRRMIVADPMQRITIQEIRRDPWFN 263 >5KZ7-A nrPDB Length = 346 Score = 251 bits (642), Expect = 2e-67, Method: Composition-based stats. Identities = 78/286 (27%), Positives = 126/286 (44%), Gaps = 32/286 (11%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 +Y ++ IG+G + V RH TG+ VA+K I RE+ ++K L HPN Sbjct: 34 NYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPN 93 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 IV L +V+ + LYL+ E+ S + D + M ++ QI+ + +CH + Sbjct: 94 IVKLFEVIETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 151 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 ++HRDLK +NLL+D IK+ADFG + F ++ T + Y +PE+ G Sbjct: 152 FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDT-FCGSPPYAAPELFQGKKYDG 210 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 VD+WS+G I L + F G + + R+ R K P Sbjct: 211 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG------------------KYRIP 252 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 + + LL K LI +P+KR + + + + N Sbjct: 253 FYMSTDCEN-----------LLKKFLILNPSKRGTLEQIMKDRWMN 287 >3PG1-A nrPDB Length = 362 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 99/308 (32%), Positives = 152/308 (49%), Gaps = 21/308 (6%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEG---------VPSTAIREISL 54 YT I G+YG V G + G VA+K++ + + +REI L Sbjct: 24 YTVQRFISSGSYGAVCAGVD-SEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 55 LKELRHPNIVSLQDVLMQDSR-----LYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYL 109 L HPNI+ L+D+ + LYL+ E + DL + + + ++ ++ Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQ--RIVISPQHIQYFM 140 Query: 110 YQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWY 169 Y IL G+ H V+HRDL P N+L+ D I + DF LAR TH V WY Sbjct: 141 YHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADAN-KTHYVTHRWY 199 Query: 170 RSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNE--V 227 R+PE+++ ++ VD+WS G + AE+ +K LF G + +QL +I +GTP E V Sbjct: 200 RAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVV 259 Query: 228 WPEVESLQDY-KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 S +DY +N+ + + V D LDL++KML ++P +RIS + AL HPY Sbjct: 260 MFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPY 319 Query: 287 FNDLDNQI 294 F L + + Sbjct: 320 FESLFDPL 327 >2JAM-A nrPDB Length = 304 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 76/288 (26%), Positives = 131/288 (45%), Gaps = 35/288 (12%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 + +E +G G + V+ + + TG++ A+K I+ S+ EI++LK+++H NI Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRD--SSLENEIAVLKKIKHENI 68 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 V+L+D+ + YL+ + +S + D I + Q+L + + H Sbjct: 69 VTLEDIYESTTHYYLVMQLVSGG--ELFDRILERGVYTEKDASLVIQQVLSAVKYLHENG 126 Query: 124 VLHRDLKPQNLLI---DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 ++HRDLKP+NLL ++ I + DFGL++ I + T Y +PEVL Sbjct: 127 IVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGI--MSTACGTPGYVAPEVL-AQKP 183 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 YS VD WSIG I L P F+ ++E +I Y+ Sbjct: 184 YSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGY----------------YEFE 227 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 P W ++ E+ D + +L DP +R + + AL+HP+ + Sbjct: 228 SPFWD---------DISESAKDFICHLLEKDPNERYTCEKALSHPWID 266 >4QMW-A nrPDB Length = 310 Score = 250 bits (638), Expect = 7e-67, Method: Composition-based stats. Identities = 86/286 (30%), Positives = 141/286 (49%), Gaps = 33/286 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E +TK+EKIG+G++G V+KG T +VVA+K I LE E+ + +EI++L + P Sbjct: 29 ELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIE-DIQQEITVLSQCDSP 87 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 + ++D++L++I E+L LD + PG +D + + + L +IL+G+ + HS Sbjct: 88 YVTKYYGSYLKDTKLWIIMEYLGGG--SALDLLEPGP-LDETQIATILREILKGLDYLHS 144 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 + +HRD+K N+L+ + G +KLADFG+A V T ++ +PEV+ SA Y Sbjct: 145 EKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSA-Y 203 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 241 + DIWS+G ELA +P + LF I Sbjct: 204 DSKADIWSLGITAIELARGEPPHSELHPMKVLFLI------------------------- 238 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 PK P +L N + + + L +P+ R + K L H + Sbjct: 239 PKNNPPTLEG---NYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 281 >2YCR-A nrPDB Length = 323 Score = 250 bits (638), Expect = 7e-67, Method: Composition-based stats. Identities = 82/306 (26%), Positives = 135/306 (44%), Gaps = 41/306 (13%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTA------IREISLL 55 ++Y + +G G G V + T + VA+K I G A EI +L Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 56 KELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 K+L HP I+ +++ + Y++ E + + D + + + + K Y YQ+L Sbjct: 70 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGG--ELFDKVVGNKRLKEATCKLYFYQMLLA 126 Query: 116 IVFCHSRRVLHRDLKPQNLLID---DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSP 172 + + H ++HRDLKP+N+L+ + IK+ DFG ++ G + T T Y +P Sbjct: 127 VQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRT-LCGTPTYLAP 185 Query: 173 EVL--LGSARYSTPVDIWSIGTIFAELATKKPLF-HGDSEIDQLFRIFRALGTPNNEVWP 229 EVL +G+A Y+ VD WS+G I + P F +++ +I EVW Sbjct: 186 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 245 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 E + E LDL+ K+L+ DP R + + AL HP+ D Sbjct: 246 E-------------------------VSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 280 Query: 290 LDNQIK 295 D + K Sbjct: 281 EDMKRK 286 >4JG6-A nrPDB Length = 355 Score = 249 bits (637), Expect = 9e-67, Method: Composition-based stats. Identities = 78/299 (26%), Positives = 129/299 (43%), Gaps = 42/299 (14%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLL-KELRH 60 + Y E IG G+Y V + HK T A+K I + EI +L + +H Sbjct: 35 DGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPT------EEIEILLRYGQH 88 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNI++L+DV +Y++ E + + LD I ++ + L+ I + + + H Sbjct: 89 PNIITLKDVYDDGKYVYVVTELMKGG--ELLDKILRQKFFSEREASAVLFTITKTVEYLH 146 Query: 121 SRRVLHRDLKPQNLL-IDDKGT---IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 ++ V+HRDLKP N+L +D+ G I++ DFG A+ + T + +PEVL Sbjct: 147 AQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLE 206 Query: 177 GSARYSTPVDIWSIGTIFAELATKKPLF---HGDSEIDQLFRIFRALGTPNNEVWPEVES 233 Y DIWS+G + + T F D+ + L RI + + W Sbjct: 207 RQG-YDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYW----- 260 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 ++ + DL+SKML DP +R++ + L HP+ D Sbjct: 261 --------------------NSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQ 299 >2JDO-A nrPDB Length = 342 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 71/299 (23%), Positives = 123/299 (41%), Gaps = 38/299 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESE-EEGVPSTAIREISLLKELR 59 M D+ ++ +G+GT+G V R K TG+ AMK +R E + + + E +L+ R Sbjct: 9 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTR 68 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HP + +L+ RL + E+ + + + + + Y +I+ + + Sbjct: 69 HPFLTALKYAFQTHDRLCFVMEYANGG--ELFFHLSRERVFTEERARFYGAEIVSALEYL 126 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 HSR V++RD+K +NL++D G IK+ DFGL + T Y +PEVL + Sbjct: 127 HSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDN- 185 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 Y VD W +G + E+ + F+ I + Sbjct: 186 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILME------------------EI 227 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYFNDLDNQ 293 FP + L LL+ +L DP +R+ K + H +F ++ Q Sbjct: 228 RFP-----------RTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQ 275 >3EB0-A nrPDB Length = 383 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 100/332 (30%), Positives = 163/332 (49%), Gaps = 49/332 (14%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + Y+ + +G G++G+V + +G+ A+KK+ + P RE+ ++K L H Sbjct: 7 KKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQD------PRYKNRELDIMKVLDHV 60 Query: 62 NIVSLQDVLMQ--------------------------------------DSRLYLIFEFL 83 NI+ L D + L +I E++ Sbjct: 61 NIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYV 120 Query: 84 SMDLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDD-KGT 141 L K L S I G+ + +L+ Y+YQ+ + + F HS + HRD+KPQNLL++ T Sbjct: 121 PDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNT 180 Query: 142 IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKK 201 +KL DFG A+ IP + + +YR+PE++LG+ Y+ +D+WSIG +F EL K Sbjct: 181 LKLCDFGSAKKL-IPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGK 239 Query: 202 PLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDEN-G 260 PLF G++ IDQL RI + +GTP E + + + FP K + + Sbjct: 240 PLFSGETSIDQLVRIIQIMGTPTKEQMIRM-NPHYTEVRFPTLKAKDWRKILPEGTPSLA 298 Query: 261 LDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 +DLL ++L Y+P RI+ A+ HP+F+ L N Sbjct: 299 IDLLEQILRYEPDLRINPYEAMAHPFFDHLRN 330 >4CZT-A nrPDB Length = 464 Score = 247 bits (631), Expect = 4e-66, Method: Composition-based stats. Identities = 75/290 (25%), Positives = 126/290 (43%), Gaps = 34/290 (11%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESE-EEGVPSTAIREISLLKELRHP 61 Y +GEGT+ V R+ G VA+K I E + + + REIS +K ++HP Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHP 71 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 N++ + +V+ +++Y + EF++ + D I + + Y Q++ + +CHS Sbjct: 72 NVIRMFEVMASKTKIYFVLEFVTGG--ELFDKISSNGRLKEDEARKYFQQLINAVDYCHS 129 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLAR--AFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 R V HRDLKP+NLL+D G +K++DFGL+ + T Y +PEV+ Sbjct: 130 RGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKG 189 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 D+WS G I L F + +IF+A + Sbjct: 190 YDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKA------------------EF 231 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 T P W + L+ ++L +PA RI+ + + +F Sbjct: 232 TCPPW-----------FSASAKKLIKRILDPNPATRITFAEVIENEWFKK 270 >4CFF-A nrPDB Length = 571 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 83/287 (28%), Positives = 123/287 (42%), Gaps = 33/287 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE-GVPSTAIREISLLKELRHPN 62 Y + +G GT+G V G H+ TG VA+K + + V REI LK RHP+ Sbjct: 35 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 94 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 I+ L V+ + +++ E++S + D I ++ + QIL + +CH Sbjct: 95 IIKLYQVISTPTDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 152 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 V+HRDLKP+N+L+D K+ADFGL+ + T + Y +PEV+ G Sbjct: 153 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAPEVISGRLYAG 211 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 VDIWS G I L F D + LF+ R P Sbjct: 212 PEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRGG-----------------VFYIP 253 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 ++ S+A+ LL ML DP KR + K H +F Sbjct: 254 EYLNRSVAT-----------LLMHMLQVDPLKRATIKDIREHEWFKQ 289 >4L42-A nrPDB Length = 346 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 76/302 (25%), Positives = 132/302 (43%), Gaps = 42/302 (13%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHK---TTGQVVAMKKIRLESEEEGVPSTA--IREISLLK 56 E + + +G+G YG V++ R TG++ AMK ++ TA E ++L+ Sbjct: 18 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 77 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 E++HP IV L +LYLI E+LS + + YL +I + Sbjct: 78 EVKHPFIVDLIYAFQTGGKLYLILEYLSGG--ELFMQLEREGIFMEDTACFYLAEISMAL 135 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 H + +++RDLKP+N++++ +G +KL DFGL + V T+ Y +PE+L+ Sbjct: 136 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 195 Query: 177 GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 236 S + VD WS+G + ++ T P F G++ + +I + Sbjct: 196 RSGH-NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK------------------ 236 Query: 237 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYFNDLD 291 K P + L + DLL K+L + A R+ HP+F ++ Sbjct: 237 CKLNLPPY-----------LTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHIN 285 Query: 292 NQ 293 + Sbjct: 286 WE 287 >4CFH-A nrPDB Length = 493 Score = 247 bits (630), Expect = 5e-66, Method: Composition-based stats. Identities = 84/287 (29%), Positives = 124/287 (43%), Gaps = 33/287 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE-GVPSTAIREISLLKELRHPN 62 Y + +G GT+G V G+H+ TG VA+K + + V REI LK RHP+ Sbjct: 35 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 94 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 I+ L V+ S ++++ E++S + D I +D + QIL G+ +CH Sbjct: 95 IIKLYQVISTPSDIFMVMEYVSGG--ELFDYICKNGRLDEKESRRLFQQILSGVDYCHRH 152 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 V+HRDLKP+N+L+D K+ADFGL+ + T + Y +PEV+ G Sbjct: 153 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAPEVISGRLYAG 211 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 VDIWS G I L F D +I D P Sbjct: 212 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI------------------CDGIFYTP 253 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 ++ L+ + + LL ML DP KR + K H +F Sbjct: 254 QY-----------LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQ 289 >5KCV-A nrPDB Length = 460 Score = 247 bits (630), Expect = 6e-66, Method: Composition-based stats. Identities = 69/300 (23%), Positives = 122/300 (40%), Gaps = 39/300 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESE-EEGVPSTAIREISLLKELR 59 M ++ ++ +G+GT+G V + K TG+ AMK ++ E + + + E +L+ R Sbjct: 161 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 220 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HP + +L+ RL + E+ + + + + + Y +I+ + + Sbjct: 221 HPFLTALKYSFQTHDRLCFVMEYANGG--ELFFHLSRERVFSEDRARFYGAEIVSALDYL 278 Query: 120 HS-RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 HS + V++RDLK +NL++D G IK+ DFGL + T Y +PEVL + Sbjct: 279 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 338 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y VD W +G + E+ + F+ I + Sbjct: 339 -DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME------------------E 379 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYFNDLDNQ 293 FP + L LLS +L DP +R+ K + H +F + Q Sbjct: 380 IRFP-----------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQ 428 >5WAX-A nrPDB Length = 310 Score = 246 bits (629), Expect = 7e-66, Method: Composition-based stats. Identities = 78/289 (26%), Positives = 129/289 (44%), Gaps = 33/289 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + Y + IG G +GV R++ GQ+VA+K I E + REI + LRHP Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERG---EKIDENVQREIINHRSLRHP 67 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NI+ ++V++ + L ++ E+ S + + I + + Q++ G+ +CHS Sbjct: 68 NIIRFKEVILTPTHLAIVMEYASGG--ELFERICNAGRFSEDEARFFFQQLISGVSYCHS 125 Query: 122 RRVLHRDLKPQNLLIDDKG--TIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 +V HRDLK +N L+D +K+ DFG +++ + + + V T Y +PEVLL Sbjct: 126 MQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLKKE 184 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFR-IFRALGTPNNEVWPEVESLQDYK 238 D+WS G + F E + I R LG S+ DY Sbjct: 185 YDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQ--------YSIPDYV 236 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 + + DL+S++ + +PA RI+ NHP+F Sbjct: 237 H----------------ISPECQDLISRIFVANPATRITIPEIRNHPWF 269 >5EZV-A nrPDB Length = 560 Score = 246 bits (629), Expect = 7e-66, Method: Composition-based stats. Identities = 83/287 (28%), Positives = 123/287 (42%), Gaps = 33/287 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE-GVPSTAIREISLLKELRHPN 62 Y + +G GT+G V G H+ TG VA+K + + V REI LK RHP+ Sbjct: 30 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 89 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 I+ L V+ + +++ E++S + D I ++ + QIL + +CH Sbjct: 90 IIKLYQVISTPTDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 147 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 V+HRDLKP+N+L+D K+ADFGL+ + T + Y +PEV+ G Sbjct: 148 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAPEVISGRLYAG 206 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 VDIWS G I L F D + LF+ R P Sbjct: 207 PEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRGG-----------------VFYIP 248 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 ++ S+A+ LL ML DP KR + K H +F Sbjct: 249 EYLNRSVAT-----------LLMHMLQVDPLKRATIKDIREHEWFKQ 284 >4CQG-A nrPDB Length = 331 Score = 246 bits (629), Expect = 8e-66, Method: Composition-based stats. Identities = 83/284 (29%), Positives = 125/284 (44%), Gaps = 33/284 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y E IG G + V H TG++VA+K + + +P EI LK LRH +I Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPR-VKTEIDALKSLRHQHI 69 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 L VL ++++++ E+ + D I + + QIL + + HS+ Sbjct: 70 CQLYHVLETKNKIFMVLEYCPGG--ELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQG 127 Query: 124 VLHRDLKPQNLLIDDKGTIKLADFGL-ARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 HRDLKP+NLL D+ +KL DFGL A+ G +L Y +PE++ G + Sbjct: 128 YAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYLG 187 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 + D+WS+G + L F D+ + +I R K P Sbjct: 188 SEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRG------------------KYEVP 229 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 KW L + + LL +ML DP KRIS + LNHP+ Sbjct: 230 KW-----------LSPSSILLLQQMLQVDPKKRISMRNLLNHPW 262 >4RED-A nrPDB Length = 351 Score = 246 bits (629), Expect = 8e-66, Method: Composition-based stats. Identities = 85/287 (29%), Positives = 124/287 (43%), Gaps = 33/287 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE-GVPSTAIREISLLKELRHPN 62 Y + +G GT+G V G+H+ TG VA+K + + V REI LK RHP+ Sbjct: 16 YILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 75 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 I+ L V+ S ++++ E++S + D I +D + QIL G+ +CH Sbjct: 76 IIKLYQVISTPSDIFMVMEYVSGG--ELFDYICKNGRLDEKESRRLFQQILSGVDYCHRH 133 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 V+HRDLKP+N+L+D K+ADFGL+ + T + Y +PEV+ G Sbjct: 134 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAPEVISGRLYAG 192 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 VDIWS G I L F D +I D P Sbjct: 193 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI------------------CDGIFYTP 234 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 ++ L+ + + LL ML DP KR S K H +F Sbjct: 235 QY-----------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ 270 >2YAB-A nrPDB Length = 361 Score = 246 bits (629), Expect = 8e-66, Method: Composition-based stats. Identities = 81/302 (26%), Positives = 138/302 (45%), Gaps = 38/302 (12%) Query: 1 MED-YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEG----VPSTAIREISLL 55 +ED Y E++G G + +V K R K+TG A K I+ RE+S+L Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSIL 69 Query: 56 KELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 +++ HPNI++L DV + + LI E +S + D + + + S++ QIL G Sbjct: 70 RQVLHPNIITLHDVYENRTDVVLILELVSGG--ELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKG----TIKLADFGLARAFGIPIRVYTHEVVTLWYRS 171 + + H++++ H DLKP+N+++ DK IKL DFGLA + + + T + + Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVA 186 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PE ++ D+WSIG I L + F GD++ + L I + E + + Sbjct: 187 PE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQT 245 Query: 232 ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 E D + K+L+ + KR++ + AL HP+ +D Sbjct: 246 -------------------------SELAKDFIRKLLVKETRKRLTIQEALRHPWITPVD 280 Query: 292 NQ 293 Q Sbjct: 281 TQ 282 >5J5T-A nrPDB Length = 370 Score = 246 bits (628), Expect = 9e-66, Method: Composition-based stats. Identities = 77/290 (26%), Positives = 137/290 (47%), Gaps = 30/290 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ED+ I++IG GTYG VYK R+ TG++ A+K I+LE E+ +EI ++K+ +HP Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV--VQQEIIMMKDCKHP 61 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV+ ++ +L++ EF + + + + + + LQG+ + HS Sbjct: 62 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYVSRETLQGLYYLHS 119 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV--LLGSA 179 + +HRD+K N+L+ D G +KLADFG++ I + T ++ +PEV + Sbjct: 120 KGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKG 179 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 Y+ D+W++G ELA +P + LF + ++ P P+++ + N Sbjct: 180 GYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQP-----PKLKDKMKWSN 234 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 +F + L +P KR + + L HP+ Sbjct: 235 SFHH-------------------FVKMALTKNPKKRPTAEKLLQHPFVTQ 265 >3I6U-A nrPDB Length = 419 Score = 246 bits (628), Expect = 9e-66, Method: Composition-based stats. Identities = 81/306 (26%), Positives = 135/306 (44%), Gaps = 41/306 (13%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTA------IREISLL 55 ++Y + +G G G V + T + VA++ I G A EI +L Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 56 KELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 K+L HP I+ +++ + Y++ E + + D + + + + K Y YQ+L Sbjct: 195 KKLNHPCIIKIKNFFDAEDY-YIVLELMEGG--ELFDKVVGNKRLKEATCKLYFYQMLLA 251 Query: 116 IVFCHSRRVLHRDLKPQNLLID---DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSP 172 + + H ++HRDLKP+N+L+ + IK+ DFG ++ G + T T Y +P Sbjct: 252 VQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRT-LCGTPTYLAP 310 Query: 173 EVL--LGSARYSTPVDIWSIGTIFAELATKKPLF-HGDSEIDQLFRIFRALGTPNNEVWP 229 EVL +G+A Y+ VD WS+G I + P F +++ +I EVW Sbjct: 311 EVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWA 370 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 E + E LDL+ K+L+ DP R + + AL HP+ D Sbjct: 371 E-------------------------VSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 405 Query: 290 LDNQIK 295 D + K Sbjct: 406 EDMKRK 411 >5D7A-A nrPDB Length = 308 Score = 246 bits (628), Expect = 9e-66, Method: Composition-based stats. Identities = 75/303 (24%), Positives = 132/303 (43%), Gaps = 41/303 (13%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP-N 62 + +E +G GTYG VYKGRH TGQ+ A+K + + +EE +EI++LK+ H N Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEE---EEIKQEINMLKKYSHHRN 75 Query: 63 IVSLQDVLMQ------DSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 I + ++ D +L+L+ EF L G + + +IL+G+ Sbjct: 76 IATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGL 135 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 H +V+HRD+K QN+L+ + +KL DFG++ + + T ++ +PEV+ Sbjct: 136 SHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 195 Query: 177 GSAR----YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 Y D+WS+G E+A P + LF I R Sbjct: 196 CDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPR-------------- 241 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 N P+ K + ++ + L+ + ++R + + + HP+ D N Sbjct: 242 ------NPAPRLKSKKWSKKFQS-------FIESCLVKNHSQRPATEQLMKHPFIRDQPN 288 Query: 293 QIK 295 + + Sbjct: 289 ERQ 291 >4D28-A nrPDB Length = 446 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 80/288 (27%), Positives = 123/288 (42%), Gaps = 32/288 (11%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHP 61 Y IGEGT+ V R+ TG VA+K + + + + REIS++K +RHP Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L +VL S++Y++ EF++ + D I + + Y Q++ + CHS Sbjct: 70 NIVRLYEVLASKSKIYIVLEFVTGG--ELFDRIVHKGRLKEDESRKYFQQLVDAVAHCHS 127 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 + V HRDLKP+NLL+D G +K++DFGL+ + + T Y +PEVL G Sbjct: 128 KGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGYD 187 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 241 + DIWS G I + F +I A + Sbjct: 188 GSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA------------------EFDC 229 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 P W L+ ++L +P RI + P+F Sbjct: 230 PPW-----------FSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRK 266 >4D2V-A nrPDB Length = 356 Score = 245 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 83/285 (29%), Positives = 124/285 (43%), Gaps = 33/285 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y E IG G + V H TG++VA+K + + +P EI LK LRH +I Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPR-IKTEIEALKNLRHQHI 89 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 L VL ++++++ E+ + D I + + QI+ + + HS+ Sbjct: 90 CQLYHVLETANKIFMVLEYCPGG--ELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQG 147 Query: 124 VLHRDLKPQNLLIDDKGTIKLADFGL-ARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 HRDLKP+NLL D+ +KL DFGL A+ G L Y +PE++ G + Sbjct: 148 YAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYLG 207 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 + D+WS+G + L F D+ + +I R K P Sbjct: 208 SEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRG------------------KYDVP 249 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 KW L + + LL +ML DP KRIS K LNHP+ Sbjct: 250 KW-----------LSPSSILLLQQMLQVDPKKRISMKNLLNHPWI 283 >2W4O-A nrPDB Length = 349 Score = 245 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 83/304 (27%), Positives = 137/304 (45%), Gaps = 42/304 (13%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 + ++G G +VY+ + K T + A+K ++ +++ V EI +L L HPNI Sbjct: 55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVR----TEIGVLLRLSHPNI 110 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 + L+++ + + L+ E ++ + D I Y + QIL+ + + H Sbjct: 111 IKLKEIFETPTEISLVLELVTGG--ELFDRIVEKGYYSERDAADAVKQILEAVAYLHENG 168 Query: 124 VLHRDLKPQNLLIDD---KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 ++HRDLKP+NLL +K+ADFGL++ + + T Y +PE+L G A Sbjct: 169 IVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQV-LMKTVCGTPGYCAPEILRGCA- 226 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 Y VD+WS+G I L F+ + +FR R L +Y Sbjct: 227 YGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFR--RILNC-------------EYYFI 271 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY-------FNDLDNQ 293 P W SL N DL+ K+++ DP KR++ AL HP+ F +D Sbjct: 272 SPWWDEVSL---------NAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTA 322 Query: 294 IKKM 297 KK+ Sbjct: 323 QKKL 326 >2Y7J-A nrPDB Length = 365 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 79/300 (26%), Positives = 131/300 (43%), Gaps = 40/300 (13%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEE------EGVPSTAIREISLL 55 + Y + IG G VV + H+ TG A+K + + +E E V RE +L Sbjct: 94 QKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHIL 153 Query: 56 KEL-RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 +++ HP+I++L D S ++L+F+ + + D + + +S + +L+ Sbjct: 154 RQVAGHPHIITLIDSYESSSFMFLVFDLMRKG--ELFDYLTEKVALSEKETRSIMRSLLE 211 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 + F H+ ++HRDLKP+N+L+DD I+L+DFG + P T Y +PE+ Sbjct: 212 AVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHL-EPGEKLRELCGTPGYLAPEI 270 Query: 175 LLGS-----ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 L S Y VD+W+ G I L P F +I L I Sbjct: 271 LKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEG---------- 320 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 Y+ + P+W DL+S++L DP R++ + AL HP+F Sbjct: 321 ------QYQFSSPEWDDR---------SSTVKDLISRLLQVDPEARLTAEQALQHPFFER 365 >1PHK-A nrPDB Length = 298 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 77/301 (25%), Positives = 130/301 (43%), Gaps = 41/301 (13%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE-------SEEEGVPSTAIREISL 54 E+Y E +G G VV + HK T + A+K I + E + + ++E+ + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 55 LKEL-RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQIL 113 L+++ HPNI+ L+D ++ +L+F+ + + D + + + + +L Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKG--ELFDYLTEKVTLSEKETRKIMRALL 134 Query: 114 QGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 173 + I H ++HRDLKP+N+L+DD IKL DFG + P T Y +PE Sbjct: 135 EVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQL-DPGEKLREVCGTPSYLAPE 193 Query: 174 VLLGSAR-----YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVW 228 ++ S Y VD+WS G I L P F ++ L I Sbjct: 194 IIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSG--------- 244 Query: 229 PEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 +Y+ P+W + + DL+S+ L+ P KR + + AL HP+F Sbjct: 245 -------NYQFGSPEWD---------DYSDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQ 288 Query: 289 D 289 Sbjct: 289 Q 289 >5D9K-A nrPDB Length = 330 Score = 245 bits (625), Expect = 2e-65, Method: Composition-based stats. Identities = 70/298 (23%), Positives = 123/298 (41%), Gaps = 40/298 (13%) Query: 3 DYTKIEKIGEGTYGVVYKGRHK---TTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR 59 + ++ +G+G++G V+ + Q+ AMK ++ + + E +L E+ Sbjct: 31 QFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVN 90 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HP IV L + +LYLI +FL + VK YL ++ + Sbjct: 91 HPFIVKLHYAFQTEGKLYLILDFLRGG--DLFTRLSKEVMFTEEDVKFYLAELALALDHL 148 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 HS +++RDLKP+N+L+D++G IKL DFGL++ + T+ Y +PEV+ Sbjct: 149 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV-NRR 207 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 ++ D WS G + E+ T F G + + I +A K Sbjct: 208 GHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKA------------------KL 249 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG-----KMALNHPYFNDLDN 292 P++ L LL + +PA R+ + H +F+ +D Sbjct: 250 GMPQF-----------LSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDW 296 >4RLP-A nrPDB Length = 288 Score = 245 bits (625), Expect = 2e-65, Method: Composition-based stats. Identities = 76/302 (25%), Positives = 132/302 (43%), Gaps = 42/302 (13%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHK---TTGQVVAMKKIRLESEEEGVPSTA--IREISLLK 56 E + + +G+G YG V++ R TG++ AMK ++ TA E ++L+ Sbjct: 5 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILE 64 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 E++HP IV L +LYLI E+LS + + YL +I + Sbjct: 65 EVKHPFIVDLIYAFQTGGKLYLILEYLSGG--ELFMQLEREGIFMEDTACFYLAEISMAL 122 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 H + +++RDLKP+N++++ +G +KL DFGL + V T+ Y +PE+L+ Sbjct: 123 GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM 182 Query: 177 GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 236 S + VD WS+G + ++ T P F G++ + +I + Sbjct: 183 RSGH-NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK------------------ 223 Query: 237 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYFNDLD 291 K P + L + DLL K+L + A R+ HP+F ++ Sbjct: 224 CKLNLPPY-----------LTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHIN 272 Query: 292 NQ 293 + Sbjct: 273 WE 274 >3MV5-A nrPDB Length = 342 Score = 245 bits (625), Expect = 2e-65, Method: Composition-based stats. Identities = 69/300 (23%), Positives = 122/300 (40%), Gaps = 39/300 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESE-EEGVPSTAIREISLLKELR 59 M ++ ++ +G+GT+G V + K TG+ AMK ++ E + + + E +L+ R Sbjct: 9 MNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSR 68 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HP + +L+ RL + E+ + + + + + Y +I+ + + Sbjct: 69 HPFLTALKYSFQTHDRLCFVMEYANGG--ELFFHLSRERVFSEDRARFYGAEIVSALDYL 126 Query: 120 HS-RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 HS + V++RDLK +NL++D G IK+ DFGL + T Y +PEVL + Sbjct: 127 HSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDN 186 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y VD W +G + E+ + F+ I + Sbjct: 187 -DYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME------------------E 227 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYFNDLDNQ 293 FP + L LLS +L DP +R+ K + H +F + Q Sbjct: 228 IRFP-----------RTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQ 276 >3GUB-A nrPDB Length = 295 Score = 244 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 78/298 (26%), Positives = 135/298 (45%), Gaps = 37/298 (12%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVP----STAIREISLLKELR 59 Y E++G G + VV K R K+TG A K I+ + RE+S+LKE++ Sbjct: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HPN+++L +V + + LI E ++ + D + + + +L QIL G+ + Sbjct: 73 HPNVITLHEVYENKTDVILIGELVAGG--ELFDFLAEKESLTEEEATEFLKQILNGVYYL 130 Query: 120 HSRRVLHRDLKPQNLLIDDKGT----IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 HS ++ H DLKP+N+++ D+ IK+ DFGLA + + T + +PE + Sbjct: 131 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNE-FKNIFGTPEFVAPE-I 188 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 + D+WSIG I L + F GD++ + L + S Sbjct: 189 VNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANV----------------SAV 232 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 +Y+ + N D + ++L+ DP KR++ + +L HP+ D Q Sbjct: 233 NYEFED---------EYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQ 281 >2J90-A nrPDB Length = 304 Score = 244 bits (623), Expect = 3e-65, Method: Composition-based stats. Identities = 76/300 (25%), Positives = 133/300 (44%), Gaps = 37/300 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVP----STAIREISLLKE 57 + Y E++G G + +V K R K TG+ A K I+ RE+++L+E Sbjct: 26 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILRE 85 Query: 58 LRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 +RHPNI++L D+ + + LI E +S + D + + + +L QIL G+ Sbjct: 86 IRHPNIITLHDIFENKTDVVLILELVSGG--ELFDFLAEKESLTEDEATQFLKQILDGVH 143 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGT----IKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 173 + HS+R+ H DLKP+N+++ DK IKL DFG+A + + T + +PE Sbjct: 144 YLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNE-FKNIFGTPEFVAPE 202 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 233 ++ D+WSIG I L + F G+++ + L I + E Sbjct: 203 -IVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEE------- 254 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 + N E D + ++L+ DP +R++ +L H + + + Sbjct: 255 ------------------YFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRR 296 >2A27-A nrPDB Length = 321 Score = 244 bits (623), Expect = 4e-65, Method: Composition-based stats. Identities = 80/302 (26%), Positives = 138/302 (45%), Gaps = 38/302 (12%) Query: 1 MED-YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVP----STAIREISLL 55 +ED Y E++G G + +V K R K+TG A K I+ RE+S+L Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSIL 69 Query: 56 KELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 +++ H N+++L DV + + LI E +S + D + + + S++ QIL G Sbjct: 70 RQVLHHNVITLHDVYENRTDVVLILELVSGG--ELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKG----TIKLADFGLARAFGIPIRVYTHEVVTLWYRS 171 + + H++++ H DLKP+N+++ DK IKL DFGLA + + + T + + Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVA 186 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PE ++ D+WSIG I L + F GD++ + L I + E + + Sbjct: 187 PE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQT 245 Query: 232 ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 E D + K+L+ + KR++ + AL HP+ +D Sbjct: 246 -------------------------SELAKDFIRKLLVKETRKRLTIQEALRHPWITPVD 280 Query: 292 NQ 293 NQ Sbjct: 281 NQ 282 >2XIK-A nrPDB Length = 294 Score = 243 bits (622), Expect = 5e-65, Method: Composition-based stats. Identities = 85/292 (29%), Positives = 139/292 (47%), Gaps = 33/292 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E +TK+++IG+G++G VYKG T +VVA+K I LE E+ + +EI++L + P Sbjct: 19 ELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIE-DIQQEITVLSQCDSP 77 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 I ++ ++L++I E+L LD + PG ++ + + + L +IL+G+ + HS Sbjct: 78 YITRYFGSYLKSTKLWIIMEYLGGG--SALDLLKPGP-LEETYIATILREILKGLDYLHS 134 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 R +HRD+K N+L+ ++G +KLADFG+A V T ++ +PEV+ SA Y Sbjct: 135 ERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSA-Y 193 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 241 DIWS+G ELA +P + LF I Sbjct: 194 DFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLI------------------------- 228 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 PK P +L + + + L DP R + K L H + + Sbjct: 229 PKNSPPTLEGQH---SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKK 277 >2I6L-A nrPDB Length = 320 Score = 243 bits (621), Expect = 6e-65, Method: Composition-based stats. Identities = 92/305 (30%), Positives = 151/305 (49%), Gaps = 25/305 (8%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 Y ++ +G G G+V+ + VA+KKI L + A+REI +++ L H N Sbjct: 12 RYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVL--TDPQSVKHALREIKIIRRLDHDN 69 Query: 63 IVSLQ--------------DVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSY 108 IV + L + + +Y++ E++ DL L+ P + + + Sbjct: 70 IVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGP----LLEEHARLF 125 Query: 109 LYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHE---V 164 +YQ+L+G+ + HS VLHRDLKP NL I+ + +K+ DFGLAR H + Sbjct: 126 MYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGL 185 Query: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPN 224 VT WYRSP +LL Y+ +D+W+ G IFAE+ T K LF G E++Q+ I ++ + Sbjct: 186 VTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVH 245 Query: 225 NEVWPEVES-LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 E E+ S + Y L + + +D L ++L + P R++ + AL+ Sbjct: 246 EEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALS 305 Query: 284 HPYFN 288 HPY + Sbjct: 306 HPYMS 310 >4JXF-A nrPDB Length = 266 Score = 243 bits (621), Expect = 6e-65, Method: Composition-based stats. Identities = 76/291 (26%), Positives = 135/291 (46%), Gaps = 34/291 (11%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESE-EEGVPSTAIREISLLKELR 59 +ED+ +G+G++ VY+ TG VA+K I ++ + G+ E+ + +L+ Sbjct: 6 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 65 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 HP+I+ L + + +YL+ E + ++ +YL + + + +++QI+ G+++ Sbjct: 66 HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLK--NRVKPFSENEARHFMHQIITGMLY 123 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 HS +LHRDL NLL+ IK+ADFGLA +P + T Y SPE+ S Sbjct: 124 LHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRS 183 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 A D+WS+G +F L +P F D+ + L ++ A Sbjct: 184 AH-GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLA------------------D 224 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 P + L DL+ ++L +PA R+S L+HP+ + Sbjct: 225 YEMPSF-----------LSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSR 264 >1ZWS-A nrPDB Length = 288 Score = 243 bits (621), Expect = 6e-65, Method: Composition-based stats. Identities = 80/302 (26%), Positives = 137/302 (45%), Gaps = 38/302 (12%) Query: 1 MED-YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVP----STAIREISLL 55 +ED Y E++G G + +V K R K+TG A K I+ RE+S+L Sbjct: 10 VEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSIL 69 Query: 56 KELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 +++ H N+++L DV + + LI E +S + D + + + S++ QIL G Sbjct: 70 RQVLHHNVITLHDVYENRTDVVLILELVSGG--ELFDFLAQKESLSEEEATSFIKQILDG 127 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKG----TIKLADFGLARAFGIPIRVYTHEVVTLWYRS 171 + + H++++ H DLKP+N+++ DK IKL DFGLA + + + T + + Sbjct: 128 VNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE-FKNIFGTPEFVA 186 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PE ++ D+WSIG I L + F GD++ + L I + E Sbjct: 187 PE-IVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEF---- 241 Query: 232 ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 + E D + K+L+ + KR++ + AL HP+ +D Sbjct: 242 ---------------------FSHTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVD 280 Query: 292 NQ 293 NQ Sbjct: 281 NQ 282 >5ZTN-A nrPDB Length = 429 Score = 243 bits (621), Expect = 7e-65, Method: Composition-based stats. Identities = 96/325 (29%), Positives = 157/325 (48%), Gaps = 46/325 (14%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH-- 60 Y ++ IG+G++G V K Q VA+K +R E + A EI +L+ LR Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNE---KRFHRQAAEEIRILEHLRKQD 154 Query: 61 ----PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 N++ + + + + + FE LSM+L + + Q LV+ + + ILQ + Sbjct: 155 KDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKK-NKFQGFSLPLVRKFAHSILQCL 213 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGT--IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 H R++H DLKP+N+L+ +G IK+ DFG + RVYT + + +YR+PEV Sbjct: 214 DALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSC--YEHQRVYT-YIQSRFYRAPEV 270 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 +LG ARY P+D+WS+G I AEL T PL G+ E DQL + LG P+ ++ + Sbjct: 271 ILG-ARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRA 329 Query: 235 QDYKNT--FPKWKPGSLASHVKNL----------------------------DENGLDLL 264 +++ ++ +P++ + S + D LD L Sbjct: 330 KNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFL 389 Query: 265 SKMLIYDPAKRISGKMALNHPYFND 289 + L +DPA R++ AL HP+ Sbjct: 390 KQCLEWDPAVRMTPGQALRHPWLRR 414 >3F3Z-A nrPDB Length = 277 Score = 243 bits (621), Expect = 7e-65, Method: Composition-based stats. Identities = 77/289 (26%), Positives = 119/289 (41%), Gaps = 35/289 (12%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 YT IG G++G V K T A KKI E+ +EI ++K L HPNI Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVED--VDRFKQEIEIMKSLDHPNI 68 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 + L + ++ +YL+ E + + + + + S + +L + +CH Sbjct: 69 IRLYETFEDNTDIYLVMELCTGG--ELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLN 126 Query: 124 VLHRDLKPQNLLI---DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 V HRDLKP+N L +KL DFGLA F P ++ +V T +Y SP+VL G Sbjct: 127 VAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFK-PGKMMRTKVGTPYYVSPQVLEG--L 183 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 Y D WS G + L P F ++ + + +I T + W Sbjct: 184 YGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWL----------- 232 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 N+ L+ ++L P +RI+ AL H +F Sbjct: 233 --------------NVSPQAESLIRRLLTKSPKQRITSLQALEHEWFEK 267 >4FZF-B nrPDB Length = 283 Score = 243 bits (620), Expect = 7e-65, Method: Composition-based stats. Identities = 82/286 (28%), Positives = 133/286 (46%), Gaps = 33/286 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E +TK+E+IG+G++G V+KG T QVVA+K I LE E+ + +EI++L + Sbjct: 8 ELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIE-DIQQEITVLSQCDSS 66 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 + ++ S+L++I E+L L P D + + L +IL+G+ + HS Sbjct: 67 YVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGP---FDEFQIATMLKEILKGLDYLHS 123 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 + +HRD+K N+L+ ++G +KLA FG+A V T ++ +PEV+ SA Y Sbjct: 124 EKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSA-Y 182 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 241 + DIWS+G ELA +P + LF I Sbjct: 183 DSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLI------------------------- 217 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 PK P +L + + + L DP+ R + K L H + Sbjct: 218 PKNNPPTLVGDFTK---SFKEFIDACLNKDPSFRPTAKELLKHKFI 260 >4KS7-A nrPDB Length = 292 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 68/279 (24%), Positives = 129/279 (46%), Gaps = 32/279 (11%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 KIGEG+ G+V R K +G+ VA+K + L ++ E+ ++++ +H N+V + Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQR--RELLFNEVVIMRDYQHFNVVEMYK 87 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 + L+++ EFL L I ++ + + +LQ + + H++ V+HRD Sbjct: 88 SYLVGEELWVLMEFLQGG---ALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRD 144 Query: 129 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIW 188 +K ++L+ G +KL+DFG + V T ++ +PEV+ + Y+T VDIW Sbjct: 145 IKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI-SRSLYATEVDIW 203 Query: 189 SIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGS 248 S+G + E+ +P + DS + + R+ + P Sbjct: 204 SLGIMVIEMVDGEPPYFSDSPVQAMKRL--------------------------RDSPPP 237 Query: 249 LASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 + + D L +ML+ DP +R + + L+HP+ Sbjct: 238 KLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFL 276 >2UV2-A nrPDB Length = 325 Score = 242 bits (618), Expect = 1e-64, Method: Composition-based stats. Identities = 80/302 (26%), Positives = 137/302 (45%), Gaps = 35/302 (11%) Query: 2 EDY-TKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ED+ I ++G+G +G VYK ++K T + A K I +SEEE + EI +L H Sbjct: 36 EDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEE--LEDYMVEIDILASCDH 93 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNIV L D ++ L+++ EF + + + + + S ++ Q L + + H Sbjct: 94 PNIVKLLDAFYYENNLWILIEFCAGGAVDAV-MLELERPLTESQIQVVCKQTLDALNYLH 152 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS-- 178 +++HRDLK N+L G IKLADFG++ I+ + T ++ +PEV++ Sbjct: 153 DNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETS 212 Query: 179 --ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 236 Y D+WS+G E+A +P H + + L +I ++ Sbjct: 213 KDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKS----------------- 255 Query: 237 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN-DLDNQIK 295 +P +LA + N D L K L + R + L HP+ D + I+ Sbjct: 256 --------EPPTLAQPSRW-SSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIR 306 Query: 296 KM 297 ++ Sbjct: 307 EL 308 >3TXO-A nrPDB Length = 353 Score = 242 bits (618), Expect = 1e-64, Method: Composition-based stats. Identities = 69/300 (23%), Positives = 127/300 (42%), Gaps = 40/300 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESE-EEGVPSTAIREISLLKELR 59 ++++ I +G+G++G V R K TG + A+K ++ + ++ + E +L R Sbjct: 22 IDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLAR 81 Query: 60 -HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 HP + L RL+ + EF++ + I + D + + Y +I+ ++F Sbjct: 82 NHPFLTQLFCCFQTPDRLFFVMEFVNGG--DLMFHIQKSRRFDEARARFYAAEIISALMF 139 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 H + +++RDLK N+L+D +G KLADFG+ + T Y +PE+L Sbjct: 140 LHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEIL-QE 198 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y VD W++G + E+ F ++E D I + + Sbjct: 199 MLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAIL------------------NDE 240 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-SGKM-----ALNHPYFNDLDN 292 +P W L E+ +L + +P R+ S L HP+F ++D Sbjct: 241 VVYPTW-----------LHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDW 289 >5F9E-A nrPDB Length = 353 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 75/296 (25%), Positives = 133/296 (44%), Gaps = 35/296 (11%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES--EEEGVPSTAIREISLLKEL 58 +ED+ + +G+G++G V+ K T Q A+K ++ + ++ V T + + L Sbjct: 18 IEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAW 77 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 HP + + L+ + E+L+ + I D S Y +I+ G+ F Sbjct: 78 EHPFLTHMFCTFQTKENLFFVMEYLNGG--DLMYHIQSCHKFDLSRATFYAAEIILGLQF 135 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 HS+ +++RDLK N+L+D G IK+ADFG+ + + T Y +PE+LLG Sbjct: 136 LHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQ 195 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 +Y+ VD WS G + E+ + FHG E + I + P Sbjct: 196 -KYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI--RMDNP--------------- 237 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGK-MALNHPYFNDLDNQ 293 +P+W L++ DLL K+ + +P KR+ + HP F +++ + Sbjct: 238 -FYPRW-----------LEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWE 281 >3Q53-A nrPDB Length = 306 Score = 241 bits (616), Expect = 2e-64, Method: Composition-based stats. Identities = 79/287 (27%), Positives = 133/287 (46%), Gaps = 32/287 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + YT+ EKIG+G G VY TGQ VA++++ L+ + + I EI +++E ++P Sbjct: 21 KKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPK--KELIINEILVMRENKNP 78 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV+ D + L+++ E+L+ L + MD + + + LQ + F HS Sbjct: 79 NIVNYLDSYLVGDELWVVMEYLAGGS---LTDVVTETCMDEGQIAAVCRECLQALEFLHS 135 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 +V+HRD+K N+L+ G++KL DFG + V T ++ +PEV+ A Y Sbjct: 136 NQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKA-Y 194 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 241 VDIWS+G + E+ +P + ++ + L+ I GTP Sbjct: 195 GPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATN-GTPE----------------- 236 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 + + L D L++ L D KR S K + H + Sbjct: 237 --------LQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELIQHQFLK 275 >3DAK-A nrPDB Length = 290 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 77/299 (25%), Positives = 127/299 (42%), Gaps = 31/299 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +DY E IG G VV + VA+K+I LE + + ++EI + + HP Sbjct: 10 DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSM-DELLKEIQAMSQCHHP 68 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSM----DLKKYL--DSIPPGQYMDSSLVKSYLYQILQG 115 NIVS + L+L+ + LS D+ K++ +D S + + L ++L+G Sbjct: 69 NIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEG 128 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI-----RVYTHEVVTLWYR 170 + + H +HRD+K N+L+ + G++++ADFG++ +V V T + Sbjct: 129 LEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWM 188 Query: 171 SPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPE 230 +PEV+ Y DIWS G ELAT +H + L + + Sbjct: 189 APEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQD 248 Query: 231 VESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 E L+ Y +F K ++S L DP KR + L H +F Sbjct: 249 KEMLKKYGKSFRK-------------------MISLCLQKDPEKRPTAAELLRHKFFQK 288 >4PDS-A nrPDB Length = 347 Score = 240 bits (614), Expect = 4e-64, Method: Composition-based stats. Identities = 83/303 (27%), Positives = 130/303 (42%), Gaps = 44/303 (14%) Query: 1 MEDYTKI-EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR 59 +D++ I E +G+G + V K +TTG+ ++K I G RE+ +L++L Sbjct: 29 FKDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKV-IGNMDGVTRELEVLQKLN 87 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HP IV L+ Y++ EF+S +D + + + QIL I + Sbjct: 88 HPRIVRLKGFYEDTESYYMVMEFVSGG--DLMDFVAAHGAVGEDAGREISRQILTAIKYI 145 Query: 120 HSRRVLHRDLKPQNLLI--DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 HS + HRDLKP N+LI DD +K+ FGLA+ G + T TL Y +PEV+ G Sbjct: 146 HSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKT-FCGTLAYVAPEVIRG 204 Query: 178 SAR------------YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNN 225 YS+ VD+WS+G + + T F G ++ +I R Sbjct: 205 KDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGP 264 Query: 226 EVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHP 285 L+D++ + E D + +L DP R + ALNHP Sbjct: 265 --------LKDFR-----------------ISEEARDFIDSLLQVDPNNRSTAAKALNHP 299 Query: 286 YFN 288 + Sbjct: 300 WIK 302 >2HAK-A nrPDB Length = 328 Score = 240 bits (613), Expect = 5e-64, Method: Composition-based stats. Identities = 74/253 (29%), Positives = 119/253 (47%), Gaps = 3/253 (1%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 +Y + IG+G + V RH TG+ VA+K I RE+ ++K L HPN Sbjct: 16 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 75 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 IV L +V+ + LYL+ E+ S + D + M ++ QI+ + +CH + Sbjct: 76 IVKLFEVIETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 133 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 ++HRDLK +NLL+D IK+ADFG + F + ++ T + Y +PE+ G Sbjct: 134 YIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDT-FCGSPPYAAPELFQGKKYDG 192 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 VD+WS+G I L + F G + + R+ R + + E+L Sbjct: 193 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLN 252 Query: 243 KWKPGSLASHVKN 255 K GSL +K+ Sbjct: 253 PIKRGSLEQIMKD 265 >4FIE-A nrPDB Length = 423 Score = 240 bits (613), Expect = 5e-64, Method: Composition-based stats. Identities = 64/289 (22%), Positives = 131/289 (45%), Gaps = 35/289 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++++ KIGEG+ G+V +++G++VA+KK+ L ++ E+ ++++ +H Sbjct: 153 LDNFI---KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR--RELLFNEVVIMRDYQH 207 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 N+V + + + L+++ EFL L I M+ + + +LQ + H Sbjct: 208 ENVVEMYNSYLVGDELWVVMEFLEGG---ALTDIVTHTRMNEEQIAAVCLAVLQALSVLH 264 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 ++ V+HRD+K ++L+ G +KL+DFG + V T ++ +PE L+ Sbjct: 265 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLP 323 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 Y VDIWS+G + E+ +P + + + + I ++ Sbjct: 324 YGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMI---------------------RDN 362 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 P ++ + + L ++L+ DPA+R + L HP+ Sbjct: 363 LPPR-----LKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAK 406 >6C9D-A nrPDB Length = 459 Score = 240 bits (613), Expect = 5e-64, Method: Composition-based stats. Identities = 73/253 (28%), Positives = 118/253 (46%), Gaps = 3/253 (1%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 +Y + IG+G + V RH TG+ VA+K I RE+ ++K L HPN Sbjct: 22 NYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPN 81 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 IV L +V+ + LYL+ E+ S + D + M ++ QI+ + +CH + Sbjct: 82 IVKLFEVIETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQK 139 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 ++HRDLK +NLL+D IK+ADFG + F + ++ + Y +PE+ G Sbjct: 140 YIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKL-DEFCGSPPYAAPELFQGKKYDG 198 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 VD+WS+G I L + F G + + R+ R + + E+L Sbjct: 199 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLN 258 Query: 243 KWKPGSLASHVKN 255 K GSL +K+ Sbjct: 259 PIKRGSLEQIMKD 271 >2YZA-A nrPDB Length = 276 Score = 240 bits (613), Expect = 6e-64, Method: Composition-based stats. Identities = 82/287 (28%), Positives = 121/287 (42%), Gaps = 33/287 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE-GVPSTAIREISLLKELRHPN 62 Y + +G GT+G V G H+ TG VA+K + + V REI LK RHP+ Sbjct: 13 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 72 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 I+ L V+ + +++ E++S + D I ++ + QIL + +CH Sbjct: 73 IIKLYQVISTPTDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAVDYCHRH 130 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 V+HRDLKP+N+L+D K+ADFGL+ + Y +PEV+ G Sbjct: 131 MVVHRDLKPENVLLDAHMNAKIADFGLSNMMS-DGEFLRDSCGSPNYAAPEVISGRLYAG 189 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 VDIWS G I L F D + LF+ R P Sbjct: 190 PEVDIWSCGVILYALLCGTLPF-DDEHVPTLFKKIRGG-----------------VFYIP 231 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 ++ S+A+ LL ML DP KR + K H +F Sbjct: 232 EYLNRSVAT-----------LLMHMLQVDPLKRATIKDIREHEWFKQ 267 >1FOT-A nrPDB Length = 318 Score = 240 bits (612), Expect = 8e-64, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 133/299 (44%), Gaps = 41/299 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE-GVPSTAIREISLLKELR 59 ++D+ + +G G++G V+ R + G+ AMK ++ E E +L + Sbjct: 5 LQDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVT 64 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HP I+ + ++++I +++ + + Q + + K Y ++ + + Sbjct: 65 HPFIIRMWGTFQDAQQIFMIMDYIEGG--ELFSLLRKSQRFPNPVAKFYAAEVCLALEYL 122 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 HS+ +++RDLKP+N+L+D G IK+ DFG A+ P YT T Y +PEV+ + Sbjct: 123 HSKDIIYRDLKPENILLDKNGHIKITDFGFAKYV--PDVTYT-LCGTPDYIAPEVV-STK 178 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 Y+ +D WS G + E+ F+ + + +I A + Sbjct: 179 PYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNA------------------EL 220 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALNHPYFNDLDNQ 293 FP + +E+ DLLS+++ D ++R+ + NHP+F ++ + Sbjct: 221 RFPPF-----------FNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWE 268 >5DBX-A nrPDB Length = 328 Score = 239 bits (611), Expect = 9e-64, Method: Composition-based stats. Identities = 75/305 (24%), Positives = 130/305 (42%), Gaps = 31/305 (10%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y E IG G VV K + VA+K+I LE + + ++EI + + HPN+ Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSM-DELLKEIQAMSQCSHPNV 71 Query: 64 VSLQDVLMQDSRLYLIFEFLSM----DLKKYL--DSIPPGQYMDSSLVKSYLYQILQGIV 117 V+ + L+L+ + LS D+ KY+ ++ +++ + L ++L+G+ Sbjct: 72 VTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLD 131 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI-----RVYTHEVVTLWYRSP 172 + H +HRDLK N+L+ + G++++ADFG++ +V V T + +P Sbjct: 132 YLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWMAP 191 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 EV+ Y D+WS G ELAT +H + L + + E Sbjct: 192 EVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKE 251 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 ++ Y +F K LLS L DP+KR + L +F N Sbjct: 252 MMKKYGKSFRK-------------------LLSLCLQKDPSKRPTAAELLKCKFFQKAKN 292 Query: 293 QIKKM 297 + + Sbjct: 293 REYLI 297 >3TKU-A nrPDB Length = 433 Score = 239 bits (610), Expect = 1e-63, Method: Composition-based stats. Identities = 72/302 (23%), Positives = 124/302 (41%), Gaps = 37/302 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRH 60 ED+ I+ IG G +G V + K T ++ AMK + + E + + E +L Sbjct: 90 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDC 149 Query: 61 PNIVSLQDVLMQDSRLYLIFEF-LSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 I +L ++ LYL+ ++ + DL L + + + Y+ +++ I Sbjct: 150 QWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDK--LPEDMARFYIGEMVLAIDSI 207 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTH-EVVTLWYRSPEVLL-- 176 H +HRD+KP N+L+D G I+LADFG V + V T Y SPE+L Sbjct: 208 HQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAM 267 Query: 177 --GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 G +Y D WS+G E+ + F+ +S ++ +I Sbjct: 268 EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN---------------- 311 Query: 235 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI---SGKMALNHPYFNDLD 291 + SHV ++ E DL+ + LI +R+ + H +F L+ Sbjct: 312 --------HEERFQFPSHVTDVSEEAKDLIQR-LICSRERRLGQNGIEDFKKHAFFEGLN 362 Query: 292 NQ 293 + Sbjct: 363 WE 364 >2F57-A nrPDB Length = 317 Score = 239 bits (610), Expect = 1e-63, Method: Composition-based stats. Identities = 67/280 (23%), Positives = 125/280 (44%), Gaps = 32/280 (11%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 KIGEG+ G+V K TG+ VA+KK+ L ++ E+ ++++ H N+V + Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQR--RELLFNEVVIMRDYHHDNVVDMYS 109 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 + L+++ EFL L I M+ + + +L+ + + H++ V+HRD Sbjct: 110 SYLVGDELWVVMEFLEGG---ALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRD 166 Query: 129 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIW 188 +K ++L+ G IKL+DFG + V T ++ +PEV+ Y T VDIW Sbjct: 167 IKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVI-SRLPYGTEVDIW 225 Query: 189 SIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGS 248 S+G + E+ +P + + + + RI +++ P Sbjct: 226 SLGIMVIEMIDGEPPYFNEPPLQAMRRI---------------------RDSLPPR---- 260 Query: 249 LASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 + + L ML+ +P++R + + L HP+ Sbjct: 261 -VKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLK 299 >4RA4-A nrPDB Length = 355 Score = 238 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 63/300 (21%), Positives = 120/300 (40%), Gaps = 39/300 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPSTAIREISLLKELR 59 + D+ + +G+G++G V K T ++ A+K ++ + ++ + E +L L Sbjct: 19 LTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLD 78 Query: 60 HP-NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 P + L RLY + E+++ + I Y +I G+ F Sbjct: 79 KPPFLTQLHSCFQTVDRLYFVMEYVNGG--DLMYHIQQVGKFKEPQAVFYAAEISIGLFF 136 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 H R +++RDLK N+++D +G IK+ADFG+ + + T Y +PE++ Sbjct: 137 LHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEII-AY 195 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y VD W+ G + E+ +P F G+ E + I Sbjct: 196 QPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIME-------------------- 235 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG-----KMALNHPYFNDLDNQ 293 S+ K+L + + + ++ PAKR+ + H +F +D + Sbjct: 236 ---------HNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWE 286 >5JZN-A nrPDB Length = 280 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 80/292 (27%), Positives = 127/292 (43%), Gaps = 34/292 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E Y IG+G + VV + ++T + A+K I+ G E+S+L+ ++HP Sbjct: 19 ERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKC-RGKEHMIQNEVSILRRVKHP 77 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV L + + + LYL+ E + D+I LY + I + HS Sbjct: 78 NIVLLIEEMDVPTELYLVMELVKGG--DLFDAITSTNKYTERDASGMLYNLASAIKYLHS 135 Query: 122 RRVLHRDLKPQNLLI----DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 ++HRD+KP+NLL+ D ++KL DFGLA P+ T Y +PE++ Sbjct: 136 LNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYT---VCGTPTYVAPEIIAE 192 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 + Y VDIW+ G I L P F G + + EV + + Sbjct: 193 TG-YGLKVDIWAAGVITYILLCGFPPFRGSGD--------------DQEVLFDQILMGQV 237 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 P W N+ ++ +L++ ML+ D +R S L HP+ ND Sbjct: 238 DFPSPYWD---------NVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVND 280 >2Z7Q-A nrPDB Length = 321 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 70/297 (23%), Positives = 125/297 (42%), Gaps = 40/297 (13%) Query: 4 YTKIEKIGEGTYGVVYKGRHK---TTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 + ++ +G+G++G V+ R +G + AMK ++ + + E +L ++ H Sbjct: 30 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNH 89 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 P +V L + +LYLI +FL + VK YL ++ G+ H Sbjct: 90 PFVVKLHYAFQTEGKLYLILDFLRGG--DLFTRLSKEVMFTEEDVKFYLAELALGLDHLH 147 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 S +++RDLKP+N+L+D++G IKL DFGL++ + T+ Y +PEV+ Sbjct: 148 SLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVV-NRQG 206 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 +S D WS G + E+ T F G + + I +A K Sbjct: 207 HSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKA------------------KLG 248 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALNHPYFNDLDN 292 P++ L LL + +PA R+ + H +++ +D Sbjct: 249 MPQF-----------LSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDW 294 >4AW2-A nrPDB Length = 437 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 74/301 (24%), Positives = 123/301 (40%), Gaps = 37/301 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRH 60 ED+ ++ IG G +G V + K +V AMK + + E + + E +L Sbjct: 74 EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDS 133 Query: 61 PNIVSLQDVLMQDSRLYLIFEF-LSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 I +L D+ LYL+ ++ + DL L + + + YL +++ I Sbjct: 134 KWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFED--RLPEEMARFYLAEMVIAIDSV 191 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTH-EVVTLWYRSPEVLL-- 176 H +HRD+KP N+L+D G I+LADFG V + V T Y SPE+L Sbjct: 192 HQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAM 251 Query: 177 --GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 G RY D WS+G E+ + F+ +S ++ +I Sbjct: 252 EGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN---------------- 295 Query: 235 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI---SGKMALNHPYFNDLD 291 + + V ++ EN DL+ + LI R+ + HP+F+ +D Sbjct: 296 --------HKERFQFPTQVTDVSENAKDLIRR-LICSREHRLGQNGIEDFKKHPFFSGID 346 Query: 292 N 292 Sbjct: 347 W 347 >4JDH-A nrPDB Length = 346 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 64/289 (22%), Positives = 131/289 (45%), Gaps = 35/289 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++++ KIGEG+ G+V +++G++VA+KK+ L ++ E+ ++++ +H Sbjct: 76 LDNFI---KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR--RELLFNEVVIMRDYQH 130 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 N+V + + + L+++ EFL L I M+ + + +LQ + H Sbjct: 131 ENVVEMYNSYLVGDELWVVMEFLEGG---ALTDIVTHTRMNEEQIAAVCLAVLQALSVLH 187 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 ++ V+HRD+K ++L+ G +KL+DFG + V T ++ +PE L+ Sbjct: 188 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLP 246 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 Y VDIWS+G + E+ +P + + + + I ++ Sbjct: 247 YGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMI---------------------RDN 285 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 P ++ + + L ++L+ DPA+R + L HP+ Sbjct: 286 LPPR-----LKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAK 329 >3IS5-A nrPDB Length = 285 Score = 237 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 75/295 (25%), Positives = 126/295 (42%), Gaps = 36/295 (12%) Query: 1 MED-YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR 59 ++D + K+G G +G V+ +++G +K I + + + EI +LK L Sbjct: 20 IDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQ-IEAEIEVLKSLD 78 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMD--LKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 HPNI+ + +V +Y++ E L++ + + G+ + V + Q++ + Sbjct: 79 HPNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALA 138 Query: 118 FCHSRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 + HS+ V+H+DLKP+N+L D IK+ DFGLA F T+ T Y +PEV Sbjct: 139 YFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSD-EHSTNAAGTALYMAPEV 197 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 + DIWS G + L T F G S + + Sbjct: 198 F--KRDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKA------------------ 237 Query: 235 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 +K + A + L +DLL +ML DP +R S L+H +F Sbjct: 238 --------TYKEPNYAVECRPLTPQAVDLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >2Q0N-A nrPDB Length = 301 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 64/289 (22%), Positives = 131/289 (45%), Gaps = 35/289 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++++ KIGEG+ G+V +++G++VA+KK+ L ++ E+ ++++ +H Sbjct: 31 LDNFI---KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR--RELLFNEVVIMRDYQH 85 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 N+V + + + L+++ EFL L I M+ + + +LQ + H Sbjct: 86 ENVVEMYNSYLVGDELWVVMEFLEGG---ALTDIVTHTRMNEEQIAAVCLAVLQALSVLH 142 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 ++ V+HRD+K ++L+ G +KL+DFG + V T ++ +PE L+ Sbjct: 143 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLP 201 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 Y VDIWS+G + E+ +P + + + + I ++ Sbjct: 202 YGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMI---------------------RDN 240 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 P ++ + + L ++L+ DPA+R + L HP+ Sbjct: 241 LPPR-----LKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAK 284 >3ZUT-A nrPDB Length = 362 Score = 237 bits (604), Expect = 5e-63, Method: Composition-based stats. Identities = 72/288 (25%), Positives = 124/288 (43%), Gaps = 31/288 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + Y ++ IG G +GV R K + ++VA+K I E + REI + LRHP Sbjct: 19 DRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERG---EKIDENVKREIINHRSLRHP 75 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV ++V++ + L ++ E+ S + + I + + Q++ G+ +CH+ Sbjct: 76 NIVRFKEVILTPTHLAIVMEYASGG--ELFERICNAGRFSEDEARFFFQQLISGVSYCHA 133 Query: 122 RRVLHRDLKPQNLLIDDKG--TIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 +V HRDLK +N L+D +K+ FG +++ + + + V T Y +PEVLL Sbjct: 134 MQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKST-VGTPAYIAPEVLLKKE 192 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 D+WS G + F E + + ++ DY + Sbjct: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQY-------AIPDYVH 245 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 + L+S++ + DPAKRIS NH +F Sbjct: 246 ----------------ISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >4XBR-A nrPDB Length = 366 Score = 236 bits (603), Expect = 7e-63, Method: Composition-based stats. Identities = 64/289 (22%), Positives = 131/289 (45%), Gaps = 35/289 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++++ KIGEG+ G+V +++G++VA+KK+ L ++ E+ ++++ +H Sbjct: 96 LDNFI---KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR--RELLFNEVVIMRDYQH 150 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 N+V + + + L+++ EFL L I M+ + + +LQ + H Sbjct: 151 ENVVEMYNSYLVGDELWVVMEFLEGG---ALTDIVTHTRMNEEQIAAVCLAVLQALSVLH 207 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 ++ V+HRD+K ++L+ G +KL+DFG + V T ++ +PE L+ Sbjct: 208 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE-LISRLP 266 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 Y VDIWS+G + E+ +P + + + + I ++ Sbjct: 267 YGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMI---------------------RDN 305 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 P ++ + + L ++L+ DPA+R + L HP+ Sbjct: 306 LPPR-----LKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAK 349 >3HDN-A nrPDB Length = 373 Score = 236 bits (603), Expect = 7e-63, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 121/302 (40%), Gaps = 40/302 (13%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREI-SLLKELRH 60 D+ ++ IG+G++G V RHK A+K + + ++ + E LLK ++H Sbjct: 39 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 98 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 P +V L +LY + ++++ + + + + Y +I + + H Sbjct: 99 PFLVGLHFSFQTADKLYFVLDYINGG--ELFYHLQRERCFLEPRARFYAAEIASALGYLH 156 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 S +++RDLKP+N+L+D +G I L DFGL + + T Y +PEVL Sbjct: 157 SLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL-HKQP 215 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 Y VD W +G + E+ P F+ + + I Sbjct: 216 YDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNIL----------------------- 252 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGK----MALNHPYFN--DLDNQI 294 N+ + LL +L D KR+ K +H +F+ + D+ I Sbjct: 253 ------NKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLI 306 Query: 295 KK 296 K Sbjct: 307 NK 308 >3UC3-A nrPDB Length = 361 Score = 236 bits (603), Expect = 9e-63, Method: Composition-based stats. Identities = 71/288 (24%), Positives = 123/288 (42%), Gaps = 31/288 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + Y ++ IG G +GV R K T ++VA+K I + + REI + LRHP Sbjct: 20 DRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGA---AIDENVQREIINHRSLRHP 76 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV ++V++ + L +I E+ S + + I + + Q+L G+ +CHS Sbjct: 77 NIVRFKEVILTPTHLAIIMEYASGG--ELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 Query: 122 RRVLHRDLKPQNLLIDDKG--TIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 ++ HRDLK +N L+D +K+ DFG +++ + + + V T Y +PEVLL Sbjct: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKST-VGTPAYIAPEVLLRQE 193 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 D+WS G + F E + + + + + ++ Sbjct: 194 YDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDI-------- 245 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 + L+S++ + DPA RIS H +F Sbjct: 246 ---------------RISPECCHLISRIFVADPATRISIPEIKTHSWF 278 >6ED6-A nrPDB Length = 415 Score = 235 bits (601), Expect = 1e-62, Method: Composition-based stats. Identities = 75/296 (25%), Positives = 121/296 (40%), Gaps = 37/296 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRH 60 EDY ++ IG G +G V RHK + +V AMK + + E + + E ++ Sbjct: 88 EDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 147 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 P +V L D LY++ E++ L ++ + K Y +++ + H Sbjct: 148 PWVVQLFYAFQDDRYLYMVMEYMPGG---DLVNLMSNYDVPEKWAKFYTAEVVLALDAIH 204 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHE-VVTLWYRSPEVLL--- 176 S ++HRD+KP N+L+D G +KLADFG V+ V T Y SPEVL Sbjct: 205 SMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG 264 Query: 177 GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 236 G Y D WS+G E+ F+ DS + +I D Sbjct: 265 GDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM------------------D 306 Query: 237 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI---SGKMALNHPYFND 289 +KN+ + ++ H +L+ L D R+ + HP+F + Sbjct: 307 HKNSLCFPEDAEISKH-------AKNLICAFLT-DREVRLGRNGVEEIRQHPFFKN 354 >6HXF-B nrPDB Length = 302 Score = 235 bits (601), Expect = 1e-62, Method: Composition-based stats. Identities = 78/293 (26%), Positives = 133/293 (45%), Gaps = 33/293 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E + + ++G+G +G VYK ++K TG + A K I +SEEE I EI +L HP Sbjct: 19 EVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEE--LEDYIVEIEILATCDHP 76 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 IV L D +L+++ EF + + + + ++ Q+L+ + F HS Sbjct: 77 YIVKLLGAYYHDGKLWIMIEFCPGGAVDAI-MLELDRGLTEPQIQVVCRQMLEALNFLHS 135 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS--- 178 +R++HRDLK N+L+ +G I+LADFG++ ++ + T ++ +PEV++ Sbjct: 136 KRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMK 195 Query: 179 -ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 Y DIWS+G E+A +P H + + L +I ++ Sbjct: 196 DTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKS------------------ 237 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 P +L + K D L L +P R S L HP+ + + Sbjct: 238 -------DPPTLLTPSKW-SVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSI 282 >2HW6-A nrPDB Length = 307 Score = 235 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 77/305 (25%), Positives = 127/305 (41%), Gaps = 31/305 (10%) Query: 1 MEDYTKI--EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL 58 ED K+ E +GEG Y V G+ A+K I E + S RE+ L + Sbjct: 10 FEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQC 67 Query: 59 R-HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 + + NI+ L + D+R YL+FE L L I ++ + + + + Sbjct: 68 QGNKNILELIEFFEDDTRFYLVFEKLQGG--SILAHIQKQKHFNEREASRVVRDVAAALD 125 Query: 118 FCHSRRVLHRDLKPQNLLIDDK---GTIKLADFGLARAFG-------IPIRVYTHEVVTL 167 F H++ + HRDLKP+N+L + +K+ DF L I T + Sbjct: 126 FLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA 185 Query: 168 WYRSPEVLL----GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTP 223 Y +PEV+ + Y D+WS+G + + + P F G D + Sbjct: 186 EYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVC 245 Query: 224 NNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 N+++ ES+Q+ K FP ++ DL+SK+L+ D +R+S L Sbjct: 246 QNKLF---ESIQEGKYEFPD-------KDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQ 295 Query: 284 HPYFN 288 HP+ Sbjct: 296 HPWVQ 300 >3UDB-A nrPDB Length = 317 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 74/288 (25%), Positives = 123/288 (42%), Gaps = 31/288 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + Y ++ IG G +GV R K ++VA+K I E + REI + LRHP Sbjct: 19 DRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERG---EKIDENVKREIINHRSLRHP 75 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV ++V++ + L ++ E+ S + + I + + Q++ G+ + H+ Sbjct: 76 NIVRFKEVILTPTHLAIVMEYASGG--ELFERICNAGRFSEDEARFFFQQLISGVSYAHA 133 Query: 122 RRVLHRDLKPQNLLIDDKG--TIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 +V HRDLK +N L+D +K+ADFG ++A + + V T Y +PEVLL Sbjct: 134 MQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQP-KSAVGTPAYIAPEVLLKKE 192 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 D+WS G + F E + + ++ DY + Sbjct: 193 YDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQY-------AIPDYVH 245 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 + L+S++ + DPAKRIS NH +F Sbjct: 246 ----------------ISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >6E9W-A nrPDB Length = 443 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 73/296 (24%), Positives = 117/296 (39%), Gaps = 37/296 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRH 60 EDY ++ IG G +G V RHK+T +V AMK + + E + + E ++ Sbjct: 102 EDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANS 161 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 P +V L D LY++ E++ L ++ + + Y +++ + H Sbjct: 162 PWVVQLFYAFQDDRYLYMVMEYMPGG---DLVNLMSNYDVPEKWARFYTAEVVLALDAIH 218 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHE-VVTLWYRSPEVLL--- 176 S +HRD+KP N+L+D G +KLADFG V V T Y SPEVL Sbjct: 219 SMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG 278 Query: 177 GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 236 G Y D WS+G E+ F+ DS + +I + Sbjct: 279 GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNS-------------- 324 Query: 237 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI---SGKMALNHPYFND 289 TFP ++ + +L+ L D R+ + H +F + Sbjct: 325 --LTFP---------DDNDISKEAKNLICAFLT-DREVRLGRNGVEEIKRHLFFKN 368 >5LOH-A nrPDB Length = 341 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 75/301 (24%), Positives = 127/301 (42%), Gaps = 40/301 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRL-ESEEEGVPSTAIREISLLKELR 59 +E+++ ++ I G +G VY G+ G++ A+K ++ + + + E L + Sbjct: 35 IEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSK 92 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 P IV L L + +YL+ E+L D+K L Y D + Y+ ++ + + Sbjct: 93 SPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIY---GYFDEEMAVKYISEVALALDY 149 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF------GIPIRVYTHEVVTLWYRSP 172 H ++HRDLKP N+LI ++G IKL DFGL++ + I T Y +P Sbjct: 150 LHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAP 209 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 E+LLG A VD W++G E T P F+ ++ I + Sbjct: 210 ELLLGRAH-GPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILK-------------- 254 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 + + L +N + +L D KR K HP F+D+D Sbjct: 255 ------------RDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDW 302 Query: 293 Q 293 + Sbjct: 303 E 303 >3DB8-A nrPDB Length = 317 Score = 233 bits (596), Expect = 5e-62, Method: Composition-based stats. Identities = 69/290 (23%), Positives = 115/290 (39%), Gaps = 33/290 (11%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELR 59 M+ Y + +G+G + Y+ T +V A K + + + EI++ K L Sbjct: 41 MKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLD 100 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 +P++V D +Y++ E + L+ + + + ++ Q +QG+ + Sbjct: 101 NPHVVGFHGFFEDDDFVYVVLEICRR--RSLLELHKRRKAVTEPEARYFMRQTIQGVQYL 158 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 H+ RV+HRDLK NL ++D +K+ DFGLA T Y +PEVL Sbjct: 159 HNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVL-CKK 217 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 +S VDIWS+G I L KP F + RI Sbjct: 218 GHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRI----------------------- 254 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 + S ++++ L+ +ML DP R S L +F Sbjct: 255 ------KKNEYSVPRHINPVASALIRRMLHADPTLRPSVAELLTDEFFTS 298 >6FDY-U nrPDB Length = 276 Score = 233 bits (595), Expect = 7e-62, Method: Composition-based stats. Identities = 82/293 (27%), Positives = 134/293 (45%), Gaps = 37/293 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGR-HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR 59 ++ + E++G GTY VYK K T +VVA+K + +S + + EI +LK +R Sbjct: 10 LDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIR 69 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HP+IV L+D +YLI EF + I + + + + ++ Q+ + F Sbjct: 70 HPHIVQLKDFQWDSDNIYLIMEFCAGG--DLSRFIHTRRILPEKVARVFMQQLASALQFL 127 Query: 120 HSRRVLHRDLKPQNLLID--DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 H R + H DLKPQN+L+ +K +KLADFG A+ + + Y +PE++ Sbjct: 128 HERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLR-GSPLYMAPEMV-C 185 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDS--EIDQLFRIFRALGTPNNEVWPEVESLQ 235 +Y VD+WS+G I E +P F S E+++ R R + P Sbjct: 186 QRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLR---------- 235 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 L + DLL ++L DP++RIS + HP+ + Sbjct: 236 ------------------PLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVD 270 >4CSV-A nrPDB Length = 275 Score = 233 bits (594), Expect = 9e-62, Method: Composition-based stats. Identities = 64/284 (22%), Positives = 123/284 (43%), Gaps = 36/284 (12%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 + T K+G G +G VY+G+ + VA+K ++ + ++E ++K+L+HPN Sbjct: 12 EITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMS---VEEFLQEAQIMKKLKHPN 68 Query: 63 IVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +V L V ++ +Y+I E++S L YL G +++ + Q+ G+ + S Sbjct: 69 LVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDC-EGHTVNAQALLDMAAQVASGMAYLES 127 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP-IRVYTHEVVTLWYRSPEVLLGSAR 180 + +HRDL +N L+ + +K+ADFGLAR + + +PE + R Sbjct: 128 QNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAPEAI-SYNR 186 Query: 181 YSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 +S D+W+ G + E+ T + + G S + + ++ R P + P Sbjct: 187 FSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCP---------- 236 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 E +L+ + P +R + L+ Sbjct: 237 ------------------EEIYELMLQCWNKSPEERPTFAETLH 262 >2X4F-A nrPDB Length = 373 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 78/288 (27%), Positives = 128/288 (44%), Gaps = 34/288 (11%) Query: 5 TKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIV 64 +K E +G G +G V+K TG +A K I+ ++ EIS++ +L H N++ Sbjct: 92 SKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKD--KEEVKNEISVMNQLDHANLI 149 Query: 65 SLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQY-MDSSLVKSYLYQILQGIVFCHSRR 123 L D + + L+ E++ + D I Y + ++ QI +GI H Sbjct: 150 QLYDAFESKNDIVLVMEYVDGG--ELFDRIIDESYNLTELDTILFMKQICEGIRHMHQMY 207 Query: 124 VLHRDLKPQNLLIDDK--GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY 181 +LH DLKP+N+L ++ IK+ DFGLAR + P T + +PEV+ Sbjct: 208 ILHLDLKPENILCVNRDAKQIKIIDFGLARRYK-PREKLKVNFGTPEFLAPEVV-NYDFV 265 Query: 182 STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTF 241 S P D+WS+G I L + F GD++ + L I Sbjct: 266 SFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILA----------------------- 302 Query: 242 PKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 +W +++ E + +SK+LI + + RIS AL HP+ +D Sbjct: 303 CRWDLED--EEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSD 348 >4U41-A nrPDB Length = 332 Score = 232 bits (592), Expect = 1e-61, Method: Composition-based stats. Identities = 77/303 (25%), Positives = 126/303 (41%), Gaps = 41/303 (13%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP-N 62 + +E +G GTYG VYKGRH TGQ+ A+K + + +EE EI++LK+ H N Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKL---EINMLKKYSHHRN 82 Query: 63 IVSLQDVLM------QDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 I + + D +L+L+ EF L G + + +IL+G+ Sbjct: 83 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 142 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 H V+HRD+K QN+L+ + +KL DFG++ + + T ++ +PEV+ Sbjct: 143 AHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 202 Query: 177 GSAR----YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 Y D+WS G E+A P + LF I R Sbjct: 203 CDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPR-------------- 248 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 N P+ K + + + L+ + +R S + L HP+ D N Sbjct: 249 ------NPPPRLKSKKWSKKFFSF-------IEGCLVKNYMQRPSTEQLLKHPFIRDQPN 295 Query: 293 QIK 295 + + Sbjct: 296 ERQ 298 >6CMJ-A nrPDB Length = 321 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 71/302 (23%), Positives = 136/302 (45%), Gaps = 43/302 (14%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES---------EEEGVPSTAIRE 51 ++ YT ++IG+G+YGVV ++ AMK + + + G +E Sbjct: 33 LDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQE 92 Query: 52 ISLLKELRHPNIVSLQDVLMQ--DSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYL 109 I++LK+L HPN+V L +VL + LY++FE ++ + +P + + + Y Sbjct: 93 IAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGP---VMEVPTLKPLSEDQARFYF 149 Query: 110 YQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWY 169 +++GI + H ++++HRD+KP NLL+ + G IK+ADFG++ F + ++ V T + Sbjct: 150 QDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAF 209 Query: 170 RSPEVLLGSARY--STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEV 227 +PE L + + +D+W++G + F + + Sbjct: 210 MAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF------------------MDERI 251 Query: 228 WPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 ++ FP ++ E+ DL+++ML +P RI HP+ Sbjct: 252 MCLHSKIKSQALEFPDQ---------PDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 302 Query: 288 ND 289 Sbjct: 303 TR 304 >1VZO-A nrPDB Length = 355 Score = 231 bits (589), Expect = 3e-61, Method: Composition-based stats. Identities = 66/305 (21%), Positives = 132/305 (43%), Gaps = 40/305 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRH---KTTGQVVAMKKIRLES--EEEGVPSTAIREISLL 55 +E++ ++ +G G YG V+ R TG++ AMK ++ + ++ E +L Sbjct: 53 IENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 112 Query: 56 KELR-HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 + +R P +V+L +++L+LI ++++ + + + V+ Y+ +I+ Sbjct: 113 EHIRQSPFLVTLHYAFQTETKLHLILDYINGG--ELFTHLSQRERFTEHEVQIYVGEIVL 170 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT-HEVVTLWYRSPE 173 + H +++RD+K +N+L+D G + L DFGL++ F T+ Y +P+ Sbjct: 171 ALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDFCGTIEYMAPD 230 Query: 174 VLL-GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 ++ G + + VD WS+G + EL T F D E + I R + E+ Sbjct: 231 IVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMS 290 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF 287 +L DL+ ++L+ DP KR+ H +F Sbjct: 291 AL-------------------------AKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFF 325 Query: 288 NDLDN 292 ++ Sbjct: 326 QKINW 330 >3UTO-A nrPDB Length = 573 Score = 231 bits (589), Expect = 3e-61, Method: Composition-based stats. Identities = 72/296 (24%), Positives = 123/296 (41%), Gaps = 34/296 (11%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++ Y E++G G +GVV++ + TG A K + + E T +EI + LRH Sbjct: 156 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV--MTPHESDKETVRKEIQTMSVLRH 213 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSI-PPGQYMDSSLVKSYLYQILQGIVFC 119 P +V+L D D+ + +I+EF+S + + + M Y+ Q+ +G+ Sbjct: 214 PTLVNLHDAFEDDNEMVMIYEFMSGG--ELFEKVADEHNKMSEDEAVEYMRQVCKGLCHM 271 Query: 120 HSRRVLHRDLKPQNLLIDDK--GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 H +H DLKP+N++ K +KL DFGL P + T + +PEV G Sbjct: 272 HENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHL-DPKQSVKVTTGTAEFAAPEVAEG 330 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 D+WS+G + L + F G+++ + L Sbjct: 331 K-PVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLR----------------------- 366 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 S + E+G D + K+L+ DP R++ AL HP+ + Sbjct: 367 --NVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAP 420 >5X3F-B nrPDB Length = 393 Score = 231 bits (589), Expect = 3e-61, Method: Composition-based stats. Identities = 74/298 (24%), Positives = 127/298 (42%), Gaps = 41/298 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELR 59 ++ + +I+ +G G++G V +HK +G AMK + + + + + E +L+ + Sbjct: 83 LDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 142 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 P +V L+ +S LY++ E+++ + + + Y QI+ + Sbjct: 143 FPFLVKLEFSFKDNSNLYMVMEYVAGG--EMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 200 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 HS +++RDLKP+NLLID +G I++ DFG A+ R +T T Y +PE++L Sbjct: 201 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWT-LCGTPEYLAPEIILSKG 257 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 Y+ VD W++G + E+A P F D I +I K Sbjct: 258 -YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG------------------KV 298 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALNHPYFNDLDN 292 FP + + DLL +L D KR NH +F D Sbjct: 299 RFP-----------SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDW 345 >5N23-A nrPDB Length = 352 Score = 230 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 75/298 (25%), Positives = 122/298 (40%), Gaps = 40/298 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELR 59 ++ + +I +G G++G V +HK TG AMK + + + + + E + + + Sbjct: 41 LDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVN 100 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 P +V L+ +S LY++ E+ + + + Y QI+ + Sbjct: 101 FPFLVKLEFSFKDNSNLYMVLEYAPGG--EMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 158 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 HS +++RDLKP+NLLID +G IK+ADFG A+ R T Y +PE++L Sbjct: 159 HSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVK--GRTPWTLCGTPEYLAPEIILSKG 216 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 Y+ VD W++G + E+A P F D I +I K Sbjct: 217 -YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG------------------KV 257 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALNHPYFNDLDN 292 FP + + DLL +L D KR NH +F D Sbjct: 258 RFP-----------SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDW 304 >4WB7-A nrPDB Length = 405 Score = 229 bits (585), Expect = 9e-61, Method: Composition-based stats. Identities = 75/298 (25%), Positives = 126/298 (42%), Gaps = 41/298 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELR 59 ++ + +I+ +G G++G V +HK TG AMK + + + + + E +L+ + Sbjct: 95 LDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 154 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 P +V L+ +S LY++ E++ + + + Y QI+ + Sbjct: 155 FPFLVKLEFSFKDNSNLYMVMEYVPGG--EMFSHLRRIGRFSEPHARFYAAQIVLTFEYL 212 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 HS +++RDLKP+NLLID +G I++ DFG A+ R +T T Y +PE++L Sbjct: 213 HSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWT-LCGTPEYLAPEIILSKG 269 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 Y+ VD W++G + E+A P F D I +I K Sbjct: 270 -YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG------------------KV 310 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALNHPYFNDLDN 292 FP + + DLL +L D KR NH +F D Sbjct: 311 RFP-----------SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDW 357 >3A8W-A nrPDB Length = 345 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 67/300 (22%), Positives = 128/300 (42%), Gaps = 31/300 (10%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE--SEEEGVPSTAIREISLLKEL 58 ++D+ + IG G+Y V R K T ++ AMK ++ E +++E + + + Sbjct: 8 LQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQAS 67 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 HP +V L +SRL+ + E+++ + + + + + Y +I + + Sbjct: 68 NHPFLVGLHSCFQTESRLFFVIEYVNGG--DLMFHMQRQRKLPEEHARFYSAEISLALNY 125 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 H R +++RDLK N+L+D +G IKL D+G+ + P + T Y +PE+L G Sbjct: 126 LHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGE 185 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y VD W++G + E+ + F I + P+ ++ +DY Sbjct: 186 -DYGFSVDWWALGVLMFEMMAGRSPFD----------IVGSSDNPD-------QNTEDYL 227 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG------KMALNHPYFNDLDN 292 + ++L +L L DP +R+ HP+F ++D Sbjct: 228 F---QVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDW 284 >1KOA-A nrPDB Length = 491 Score = 228 bits (583), Expect = 1e-60, Method: Composition-based stats. Identities = 72/296 (24%), Positives = 123/296 (41%), Gaps = 34/296 (11%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ++ Y E++G G +GVV++ + TG A K + + E T +EI + LRH Sbjct: 50 LDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFV--MTPHESDKETVRKEIQTMSVLRH 107 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSI-PPGQYMDSSLVKSYLYQILQGIVFC 119 P +V+L D D+ + +I+EF+S + + + M Y+ Q+ +G+ Sbjct: 108 PTLVNLHDAFEDDNEMVMIYEFMSGG--ELFEKVADEHNKMSEDEAVEYMRQVCKGLCHM 165 Query: 120 HSRRVLHRDLKPQNLLIDDK--GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 H +H DLKP+N++ K +KL DFGL P + T + +PEV G Sbjct: 166 HENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHL-DPKQSVKVTTGTAEFAAPEVAEG 224 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 D+WS+G + L + F G+++ + L Sbjct: 225 K-PVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLR----------------------- 260 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 S + E+G D + K+L+ DP R++ AL HP+ + Sbjct: 261 --NVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAP 314 >3ORZ-A nrPDB Length = 316 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 68/301 (22%), Positives = 120/301 (39%), Gaps = 41/301 (13%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRH 60 ED+ + +GEG++ V R T + A+K + + +E RE ++ L H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 P V L D +LY + + L I D + + Y +I+ + + H Sbjct: 97 PFFVKLYFCFQDDEKLYFGLSYAKNG--ELLKYIRKIGSFDETCTRFYTAEIVSALEYLH 154 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY--THEVVTLWYRSPEVLLGS 178 + ++HRDLKP+N+L+++ I++ DFG A+ + V T Y SPE+L Sbjct: 155 GKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEK 214 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 + D+W++G I +L P F +E +I + + Sbjct: 215 SAC-KSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL------------------E 255 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKM------ALNHPYFNDLDN 292 FP+ DL+ K+L+ D KR+ + HP+F + Sbjct: 256 YDFPE-----------KFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTW 304 Query: 293 Q 293 + Sbjct: 305 E 305 >3PFQ-A nrPDB Length = 674 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 58/300 (19%), Positives = 119/300 (39%), Gaps = 39/300 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES--EEEGVPSTAIREISLLKEL 58 + D+ + +G+G++G V K T ++ A+K ++ + +++ V T + + L Sbjct: 340 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 399 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 + P + L RLY + E+++ + I Y +I G+ F Sbjct: 400 KPPFLTQLHSCFQTMDRLYFVMEYVNGG--DLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 457 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 S+ +++RDLK N+++D +G IK+ADFG+ + T Y +PE++ Sbjct: 458 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII-AY 516 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y VD W+ G + E+ + F G+ E + I Sbjct: 517 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME-------------------- 556 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG-----KMALNHPYFNDLDNQ 293 ++ K++ + + + ++ P KR+ + H +F +D + Sbjct: 557 ---------HNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWE 607 >1U5R-A nrPDB Length = 348 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 68/286 (23%), Positives = 128/286 (44%), Gaps = 36/286 (12%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVP-STAIREISLLKELRHPN 62 ++ + +IG G++G VY R +VVA+KK+ ++ I+E+ L++LRHPN Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 115 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 + + +++ +L+ E+ L+ + + + + + LQG+ + HS Sbjct: 116 TIQYRGCYLREHTAWLVMEYCLGSASDLLE--VHKKPLQEVEIAAVTHGALQGLAYLHSH 173 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL--LGSAR 180 ++HRD+K N+L+ + G +KL DFG A V T ++ +PEV+ + + Sbjct: 174 NMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVILAMDEGQ 229 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 Y VD+WS+G ELA +KP + + L+ I + N Sbjct: 230 YDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ--------------------NE 269 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 P + G + + +N + L P R + ++ L H + Sbjct: 270 SPALQSGHWSEYFRN-------FVDSCLQKIPQDRPTSEVLLKHRF 308 >2OU7-A nrPDB Length = 335 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 67/281 (23%), Positives = 110/281 (39%), Gaps = 33/281 (11%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 +G+G + ++ T +V A K + + + EIS+ + L H ++V Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 + ++++ E + L+ + + + YL QI+ G + H RV+HRD Sbjct: 109 FFEDNDFVFVVLELCRR--RSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRD 166 Query: 129 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIW 188 LK NL +++ +K+ DFGLA T Y +PEVL S VD+W Sbjct: 167 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH-SFEVDVW 225 Query: 189 SIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGS 248 SIG I L KP F + RI + + + P Sbjct: 226 SIGCIMYTLLVGKPPFETSCLKETYLRI------------------KKNEYSIP------ 261 Query: 249 LASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 K+++ L+ KML DP R + LN +F Sbjct: 262 -----KHINPVAASLIQKMLQTDPTARPTINELLNDEFFTS 297 >4YNZ-A nrPDB Length = 342 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 77/283 (27%), Positives = 126/283 (44%), Gaps = 32/283 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y + +G+G G+V G H T Q VA+K + E E V REI++LK + HP++ Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 + L DV LYL+ E +S + D + + + + QI+ + FCHS Sbjct: 72 LKLHDVYENKKYLYLVLEHVSGG--ELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHS 129 Query: 124 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYST 183 + HRDLKP+NLL+D++ I++ADFG+A + + + + Y PEV+ G Sbjct: 130 ICHRDLKPENLLLDERNNIRIADFGMA-SLQVGDSLLETSCGSPHYACPEVIRGEKYDGR 188 Query: 184 PVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPK 243 D+WS G I L F D+ L ++ R + + + P+ +S Sbjct: 189 KADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQS---------- 238 Query: 244 WKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 LL M+ D A+R++ + H + Sbjct: 239 -------------------LLRGMIEVDAARRLTLEHIQKHIW 262 >4APC-A nrPDB Length = 350 Score = 227 bits (580), Expect = 3e-60, Method: Composition-based stats. Identities = 69/284 (24%), Positives = 125/284 (44%), Gaps = 31/284 (10%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 ME Y +++KIGEG++G + G+ +K+I + + RE+++L ++H Sbjct: 23 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 82 Query: 61 PNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 PNIV ++ ++ LY++ ++ DL K +++ G + + QI + Sbjct: 83 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINA-QKGVLFQEDQILDWFVQICLALKHV 141 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 H R++LHRD+K QN+ + GT++L DFG+AR + + + T +Y SPE+ Sbjct: 142 HDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICENK- 200 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 Y+ DIW++G + EL T K F S + + +I P Sbjct: 201 PYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPP---------------- 244 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 + + L+S++ +P R S L Sbjct: 245 ------------VSLHYSYDLRSLVSQLFKRNPRDRPSVNSILE 276 >4B6L-A nrPDB Length = 281 Score = 227 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 71/287 (24%), Positives = 104/287 (36%), Gaps = 33/287 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPN 62 Y K +G+G + Y+ TG A+K I + + + EI L ++L+H + Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 70 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 IV +Y+ E S K + V+ YL QIL G+ + H R Sbjct: 71 IVRFSHHFEDADNIYIFLELCSR--KSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQR 128 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 +LHRDLK N I + +K+ DFGLA P + T Y +PEVLL Sbjct: 129 GILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGH-G 187 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 D+WS+G + L P F + I + T Sbjct: 188 PEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPA----------------- 230 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 +L LL+ +L P R S L H +F Sbjct: 231 ------------SLSLPARQLLAAILRASPRDRPSIDQILRHDFFTK 265 >2GCD-A nrPDB Length = 309 Score = 227 bits (578), Expect = 6e-60, Method: Composition-based stats. Identities = 68/286 (23%), Positives = 128/286 (44%), Gaps = 36/286 (12%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVP-STAIREISLLKELRHPN 62 ++ + +IG G++G VY R +VVA+KK+ ++ I+E+ L++LRHPN Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPN 76 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 + + +++ +L+ E+ L+ + + + + + LQG+ + HS Sbjct: 77 TIQYRGCYLREHTAWLVMEYCLGSASDLLE--VHKKPLQEVEIAAVTHGALQGLAYLHSH 134 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL--LGSAR 180 ++HRD+K N+L+ + G +KL DFG A V T ++ +PEV+ + + Sbjct: 135 NMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPA----NSFVGTPYWMAPEVILAMDEGQ 190 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 Y VD+WS+G ELA +KP + + L+ I + N Sbjct: 191 YDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ--------------------NE 230 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 P + G + + +N + L P R + ++ L H + Sbjct: 231 SPALQSGHWSEYFRN-------FVDSCLQKIPQDRPTSEVLLKHRF 269 >4J52-A nrPDB Length = 293 Score = 226 bits (577), Expect = 9e-60, Method: Composition-based stats. Identities = 67/281 (23%), Positives = 110/281 (39%), Gaps = 33/281 (11%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 +G+G + ++ T +V A K + + + EIS+ + L H ++V Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 + ++++ E + L+ + + + YL QI+ G + H RV+HRD Sbjct: 82 FFEDNDFVFVVLELCRR--RSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRD 139 Query: 129 LKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIW 188 LK NL +++ +K+ DFGLA T Y +PEVL S VD+W Sbjct: 140 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGH-SFEVDVW 198 Query: 189 SIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGS 248 SIG I L KP F + RI + + + P Sbjct: 199 SIGCIMYTLLVGKPPFETSCLKETYLRI------------------KKNEYSIP------ 234 Query: 249 LASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 K+++ L+ KML DP R + LN +F Sbjct: 235 -----KHINPVAASLIQKMLQTDPTARPTINELLNDEFFTS 270 >3ALO-A nrPDB Length = 327 Score = 226 bits (577), Expect = 9e-60, Method: Composition-based stats. Identities = 68/293 (23%), Positives = 121/293 (41%), Gaps = 32/293 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ED + +IG G YG V K HK +GQ++A+K+IR +E+ + +++ P Sbjct: 22 EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCP 81 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPP--GQYMDSSLVKSYLYQILQGIVFC 119 IV L ++ ++ E +S K+ + + ++ ++ + Sbjct: 82 YIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHL 141 Query: 120 HSR-RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL-- 176 +++HRD+KP N+L+D G IKL DFG++ I T + Y +PE + Sbjct: 142 KENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSI-AKTRDAGCRPYMAPERIDPS 200 Query: 177 -GSARYSTPVDIWSIGTIFAELATKKPLFH-GDSEIDQLFRIFRALGTPNNEVWPEVESL 234 Y D+WS+G ELAT + + +S DQL ++ + Sbjct: 201 ASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKG--------------- 245 Query: 235 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 P S + + ++ ++ L D +KR K L HP+ Sbjct: 246 ---------DPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI 289 >2WO6-A nrPDB Length = 382 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 88/335 (26%), Positives = 145/335 (43%), Gaps = 47/335 (14%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 M+ Y IG+G++G V K + + VA+K I+ + +R + L+ + Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDT 112 Query: 61 P---NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 IV L+ M + L L+FE LS +L L + + + +L + + Q+ ++ Sbjct: 113 EMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTN-FRGVSLNLTRKFAQQMCTALL 171 Query: 118 FCH--SRRVLHRDLKPQNLLIDD--KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 173 F ++H DLKP+N+L+ + + IK+ DFG + G I Y + + +YRSPE Sbjct: 172 FLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQY---IQSRFYRSPE 228 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 233 VLLG Y +D+WS+G I E+ T +PLF G +E+DQ+ +I LG P + + Sbjct: 229 VLLG-MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPK 287 Query: 234 LQDYKNTFPK--WKPGSLASHVKNLDENG------------------------------- 260 + + P W + G Sbjct: 288 ARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYL 347 Query: 261 --LDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 DL+ +ML YDP RI AL H +F ++ Sbjct: 348 KFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE 382 >4CRL-A nrPDB Length = 406 Score = 225 bits (575), Expect = 1e-59, Method: Composition-based stats. Identities = 116/316 (36%), Positives = 174/316 (55%), Gaps = 39/316 (12%) Query: 9 KIGEGTYGVVYKGRHKTTGQV--VAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 K+G GTYG VYK + K A+K+I E G+ +A REI+LL+EL+HPN++SL Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL 84 Query: 67 QDVLMQ--DSRLYLIFEFLSMDLKKYLDSIPPGQ------YMDSSLVKSYLYQILQGIVF 118 Q V + D +++L+F++ DL + + + +VKS LYQIL GI + Sbjct: 85 QKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHY 144 Query: 119 CHSRRVLHRDLKPQNLLID----DKGTIKLADFGLARAFGIPIRVYTH---EVVTLWYRS 171 H+ VLHRDLKP N+L+ ++G +K+AD G AR F P++ VVT WYR+ Sbjct: 145 LHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRA 204 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSE---------IDQLFRIFRALGT 222 PE+LLG+ Y+ +DIW+IG IFAEL T +P+FH E DQL RIF +G Sbjct: 205 PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGF 264 Query: 223 PNNEVWPEVESLQDYKNTFPKWKPGS---------LASHVKNLDENGLDLLSKMLIYDPA 273 P ++ W +++ + ++ ++ + + H D LL K+L DP Sbjct: 265 PADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPI 324 Query: 274 KRISGKMALNHPYFND 289 KRI+ + A+ PYF + Sbjct: 325 KRITSEQAMQDPYFLE 340 >2I0E-A nrPDB Length = 353 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 58/300 (19%), Positives = 119/300 (39%), Gaps = 39/300 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES--EEEGVPSTAIREISLLKEL 58 + D+ + +G+G++G V K T ++ A+K ++ + +++ V T + + L Sbjct: 19 LTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPG 78 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 + P + L RLY + E+++ + I Y +I G+ F Sbjct: 79 KPPFLTQLHSCFQTMDRLYFVMEYVNGG--DLMYHIQQVGRFKEPHAVFYAAEIAIGLFF 136 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 S+ +++RDLK N+++D +G IK+ADFG+ + T Y +PE++ Sbjct: 137 LQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII-AY 195 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y VD W+ G + E+ + F G+ E + I Sbjct: 196 QPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME-------------------- 235 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG-----KMALNHPYFNDLDNQ 293 ++ K++ + + + ++ P KR+ + H +F +D + Sbjct: 236 ---------HNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWE 286 >5YV8-A nrPDB Length = 298 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 71/317 (22%), Positives = 135/317 (42%), Gaps = 58/317 (18%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES--------------------- 39 + YT ++IG+G+YGVV ++ AMK + + Sbjct: 12 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 71 Query: 40 ---EEEGVPSTAIREISLLKELRHPNIVSLQDVLMQ--DSRLYLIFEFLSMDLKKYLDSI 94 + G +EI++LK+L HPN+V L +VL + LY++FE ++ + + Sbjct: 72 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGP---VMEV 128 Query: 95 PPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG 154 P + + + Y +++GI + H ++++HRD+KP NLL+ + G IK+ADFG++ F Sbjct: 129 PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK 188 Query: 155 IPIRVYTHEVVTLWYRSPEVLLGSARY--STPVDIWSIGTIFAELATKKPLFHGDSEIDQ 212 + ++ V T + +PE L + + +D+W++G + F Sbjct: 189 GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF-------- 240 Query: 213 LFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDP 272 + + ++ FP ++ E+ DL+++ML +P Sbjct: 241 ----------MDERIMCLHSKIKSQALEFPDQ---------PDIAEDLKDLITRMLDKNP 281 Query: 273 AKRISGKMALNHPYFND 289 RI HP+ Sbjct: 282 ESRIVVPEIKLHPWVTR 298 >2VD5-A nrPDB Length = 412 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 78/303 (25%), Positives = 123/303 (40%), Gaps = 39/303 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRH 60 +D+ ++ IG G + V + K TGQV AMK + + + + G S E +L Sbjct: 61 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 120 Query: 61 PNIVSLQDVLMQDSRLYLIFEF-LSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 I L ++ LYL+ E+ + DL L G+ + + + + YL +I+ I Sbjct: 121 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKF--GERIPAEMARFYLAEIVMAIDSV 178 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT-HEVVTLWYRSPEVLLG- 177 H +HRD+KP N+L+D G I+LADFG V + V T Y SPE+L Sbjct: 179 HRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAV 238 Query: 178 -----SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 + Y D W++G E+ + F+ DS + +I Sbjct: 239 GGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIV--------------- 283 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI---SGKMALNHPYFND 289 YK SL + + E D + ++L P R+ HP+F Sbjct: 284 ---HYKEHL------SLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFFFG 333 Query: 290 LDN 292 LD Sbjct: 334 LDW 336 >3LM0-A nrPDB Length = 327 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 130/297 (43%), Gaps = 33/297 (11%) Query: 1 MEDYTKI--EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL 58 ++ + +++G G + VV + K+TGQ A K ++ + + + EI++L+ Sbjct: 26 FNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELA 85 Query: 59 R-HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 + P +++L +V S + LI E+ + L + + + V + QIL+G+ Sbjct: 86 KSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVY 145 Query: 118 FCHSRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 + H ++H DLKPQN+L+ G IK+ DFG++R G + + T Y +PE+ Sbjct: 146 YLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELR-EIMGTPEYLAPEI 204 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 L +T D+W+IG I L T F G+ + I + + E Sbjct: 205 L-NYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEET------- 256 Query: 235 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 ++ + D + +L+ +P KR + ++ L+H + D Sbjct: 257 ------------------FSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWD 295 >6CKI-A nrPDB Length = 316 Score = 224 bits (572), Expect = 3e-59, Method: Composition-based stats. Identities = 81/305 (26%), Positives = 136/305 (44%), Gaps = 31/305 (10%) Query: 1 MED-YTKIE-KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL 58 ED Y E +GEG + V + T Q A+K I E + + S RE+ +L + Sbjct: 10 FEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKII--EKQPGHIRSRVFREVEMLYQC 67 Query: 59 R-HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 + H N++ L + ++ R YL+FE + L I ++ + + + + Sbjct: 68 QGHRNVLELIEFFEEEDRFYLVFEKMRGG--SILSHIHKRRHFNELEASVVVQDVASALD 125 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGT---IKLADFGLA---RAFGIPIRVYTHEVVTL---- 167 F H++ + HRDLKP+N+L + +K+ DFGL + G + T E++T Sbjct: 126 FLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSA 185 Query: 168 WYRSPEVL----LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTP 223 Y +PEV+ ++ Y D+WS+G I L + P F G D + A Sbjct: 186 EYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPAC 245 Query: 224 NNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 N ++ ES+Q+ K FP ++ DL+SK+L+ D +R+S L Sbjct: 246 QNMLF---ESIQEGKYEFPD-------KDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQ 295 Query: 284 HPYFN 288 HP+ Sbjct: 296 HPWVQ 300 >4B8L-A nrPDB Length = 286 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 79/289 (27%), Positives = 129/289 (44%), Gaps = 35/289 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELR 59 ++D+ +G+G +G VY R K ++A+K + + + E+EGV REI + LR Sbjct: 14 IDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLR 73 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HPNI+ + + R+YL+ EF + + D +++ ++ + +C Sbjct: 74 HPNILRMYNYFHDRKRIYLMLEFAPRG--ELYKELQKHGRFDEQRSATFMEELADALHYC 131 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 H R+V+HRD+KP+NLL+ KG +K+ADFG + P TL Y PE++ G Sbjct: 132 HERKVIHRDIKPENLLMGYKGELKIADFGWS--VHAPSLRRRTMCGTLDYLPPEMIEGK- 188 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 + VD+W G + E P F S + RI Sbjct: 189 THDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNV------------------DL 230 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 FP + L + DL+SK+L Y P +R+ K + HP+ Sbjct: 231 KFPPF-----------LSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVK 268 >4C0T-A nrPDB Length = 974 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 73/300 (24%), Positives = 120/300 (40%), Gaps = 43/300 (14%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE--SEEEGVPSTAIREISLLKELRH 60 D+ +++GEG+Y V K TG+ A+K + +E+ V I + +L + Sbjct: 267 DFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNR 326 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 ++SL LY + ++ S + L I ++ + + QIL I + H Sbjct: 327 LGVISLYFTFQDKDSLYFVLDYASNG--ELLTLIKRYNTLNEECTRHFGAQILDAIKYMH 384 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY---------THEVVTLWYRS 171 V+HRDLKP+N+L+DDK I++ DFG AR V T Y S Sbjct: 385 DNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVS 444 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PE+L P D+W+ G I ++ KP F +E +I + Sbjct: 445 PELLENK-YCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFA--------- 494 Query: 232 ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 + FP DL+ K+L+ P++R + H +F +D Sbjct: 495 -----FSAGFPTI---------------IRDLIKKILVLQPSRRATIPEIQKHYFFQSVD 534 >4I6B-A nrPDB Length = 308 Score = 223 bits (569), Expect = 7e-59, Method: Composition-based stats. Identities = 65/289 (22%), Positives = 112/289 (38%), Gaps = 33/289 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAI-REISLLKELRH 60 + Y++ + +G+G + Y+ T +V A K I + I +EI L + L H Sbjct: 28 KRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHH 87 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 ++V +Y++ E+ S ++ + + + V+ YL QI+ G+ + H Sbjct: 88 KHVVQFYHYFEDKENIYILLEYCSRRSMAHI--LKARKVLTEPEVRYYLRQIVSGLKYLH 145 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 + +LHRDLK N I++ +K+ DFGLA T Y SPEVL Sbjct: 146 EQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL-NKQG 204 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 + DIW++G + + +P F + + I A T Sbjct: 205 HGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMP---------------- 248 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 +L L++ ML +P R S + H +F Sbjct: 249 -------------SSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFTQ 284 >5DYK-A nrPDB Length = 853 Score = 223 bits (569), Expect = 7e-59, Method: Composition-based stats. Identities = 87/298 (29%), Positives = 131/298 (43%), Gaps = 38/298 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR-EISLLKELR 59 M++ IG GT+G V HK T A+K + S I+ E + E Sbjct: 538 MDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAEND 597 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HP I+ L Y + E ++ + D+I + S + YL I+ I + Sbjct: 598 HPFIIRLVRTFKDSKYFYFLTELVTGG--ELYDAIRKLGLLSKSQAQFYLGSIILAIEYL 655 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 H R +++RDLKP+N+L+D +G +KL DFG A+ R YT V T Y +PEV+LG Sbjct: 656 HERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQ--GRAYT-LVGTPHYMAPEVILGKG 712 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 Y VDIW++G E F G+ E DQL IFR + T Sbjct: 713 -YGCTVDIWALGICLYEFICGPLPF-GNDEEDQL-EIFRDILTGQ--------------L 755 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG-----KMALNHPYFNDLDN 292 TFP + D + ++L+ ++L P RI K +HP+F++ + Sbjct: 756 TFPDYV----------TDTDSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNW 803 >3KN6-A nrPDB Length = 325 Score = 223 bits (569), Expect = 7e-59, Method: Composition-based stats. Identities = 73/286 (25%), Positives = 118/286 (41%), Gaps = 30/286 (10%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHPNIVSL 66 + +GEG++ + K HK + Q A+K I E +EI+ LK HPNIV L Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEAN-----TQKEITALKLCEGHPNIVKL 71 Query: 67 QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 +V +L+ E L+ + + I ++ + + +++ + H V+H Sbjct: 72 HEVFHDQLHTFLVMELLNGG--ELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVH 129 Query: 127 RDLKPQNLLI---DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYST 183 RDLKP+NLL +D IK+ DFG AR + TL Y +PE LL Y Sbjct: 130 RDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE-LLNQNGYDE 188 Query: 184 PVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPK 243 D+WS+G I + + + F R+L + + D+ Sbjct: 189 SCDLWSLGVILYTMLSGQVPFQSHD---------RSLTCTSAVEIMKKIKKGDFSFEGEA 239 Query: 244 WKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 W KN+ + DL+ +L DP KR+ + + D Sbjct: 240 W---------KNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQD 276 >5KKR-C nrPDB Length = 395 Score = 223 bits (568), Expect = 9e-59, Method: Composition-based stats. Identities = 77/314 (24%), Positives = 128/314 (40%), Gaps = 34/314 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +D+ KI ++G G GVV+K HK +G V+A K I LE + + + IRE+ +L E P Sbjct: 68 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE-IKPAIRNQIIRELQVLHECNSP 126 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC-H 120 IV D + + E + + + ++ +++G+ + Sbjct: 127 YIVGFYGAFYSDGEISICMEHMDGGSLD--QVLKKAGRIPEQILGKVSIAVIKGLTYLRE 184 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 +++HRD+KP N+L++ +G IKL DFG++ + V T Y SPE L G+ Sbjct: 185 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQGT-H 241 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRI---------------------FRA 219 YS DIWS+G E+A + + + Sbjct: 242 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSS 301 Query: 220 LGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGK 279 G + E L N P P ++ S D ++K LI +PA+R K Sbjct: 302 YGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSL------EFQDFVNKCLIKNPAERADLK 355 Query: 280 MALNHPYFNDLDNQ 293 + H + D + Sbjct: 356 QLMVHAFIKRSDAE 369 >3VN9-A nrPDB Length = 340 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 69/293 (23%), Positives = 121/293 (41%), Gaps = 34/293 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +D I ++G G YGVV K RH +GQ++A+K+IR + + ++ + P Sbjct: 51 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 110 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCH 120 V+ L ++ +++ E + L K+ I GQ + ++ I++ + H Sbjct: 111 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 170 Query: 121 SR-RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL---L 176 S+ V+HRD+KP N+LI+ G +K+ DFG++ + T + Y +PE + L Sbjct: 171 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYL-VDSVAKTIDAGCKPYMAPERINPEL 229 Query: 177 GSARYSTPVDIWSIGTIFAELA-TKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 YS DIWS+G ELA + P + QL ++ Sbjct: 230 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE----------------- 272 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 S +D S+ L + +R + + HP+F Sbjct: 273 ----------EPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 >2BRG-A nrPDB Length = 297 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 74/291 (25%), Positives = 135/291 (46%), Gaps = 31/291 (10%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 +ED+ ++ +GEG YG V ++ T + VA+K + ++ + P +EI + K L H Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVD-CPENIKKEICINKMLNH 64 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 N+V + + YL E+ S + D I P M + + +Q++ G+V+ H Sbjct: 65 ENVVKFYGHRREGNIQYLFLEYCSGG--ELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLH 122 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLAR--AFGIPIRVYTHEVVTLWYRSPEVLLGS 178 + HRD+KP+NLL+D++ +K++DFGLA + R+ TL Y +PE+L Sbjct: 123 GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRR 182 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 ++ PVD+WS G + + + + S+ + D+K Sbjct: 183 EFHAEPVDVWSCGIVLTAMLAGELPWDQPSD--------------------SCQEYSDWK 222 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 + + + K +D L LL K+L+ +P+ RI+ ++N Sbjct: 223 ------EKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNK 267 >5X8I-B nrPDB Length = 346 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 87/333 (26%), Positives = 136/333 (40%), Gaps = 49/333 (14%) Query: 3 DYTKIEKIGEGTYGVVYKGR-HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR-- 59 Y ++ +GEG +G V + HK G+ VA+K ++ + A EI +L+ L Sbjct: 14 RYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK---NVDRYCEAARSEIQVLEHLNTT 70 Query: 60 HPN----IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 PN V + + + ++FE L + ++ ++ YQI + Sbjct: 71 DPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKE-NGFLPFRLDHIRKMAYQICKS 129 Query: 116 IVFCHSRRVLHRDLKPQNLLIDD-------------------KGTIKLADFGLARAFGIP 156 + F HS ++ H DLKP+N+L IK+ DFG A Sbjct: 130 VNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY---D 186 Query: 157 IRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRI 216 ++ V T YR+PEV+L +S P D+WSIG I E +F + L + Sbjct: 187 DEHHSTLVSTRHYRAPEVILALG-WSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMM 245 Query: 217 FRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKN---------------LDENGL 261 R LG + + + + + W S A + E Sbjct: 246 ERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLF 305 Query: 262 DLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294 DL+ KML YDPAKRI+ + AL HP+F+ L I Sbjct: 306 DLIQKMLEYDPAKRITLREALKHPFFDLLKKSI 338 >3HKO-A nrPDB Length = 345 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 78/344 (22%), Positives = 126/344 (36%), Gaps = 73/344 (21%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR---EISLLKEL 58 + Y IG+G+YGVV T + A+K + + P R E+ L+K+L Sbjct: 26 KKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKL 85 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMD-----LKKYLDSIPPGQYMD------------ 101 HPNI L +V + + L+ E L ++D MD Sbjct: 86 HHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPEC 145 Query: 102 ---------------------SSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKG 140 L+ + + QI + + H++ + HRD+KP+N L Sbjct: 146 NEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNK 205 Query: 141 --TIKLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVL-LGSARYSTPVDIWSIGTI 193 IKL DFGL++ F T + T ++ +PEVL + Y D WS G + Sbjct: 206 SFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGVL 265 Query: 194 FAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHV 253 L F G ++ D + ++ + P + Sbjct: 266 LHLLLMGAVPFPGVNDADTISQVLN----------------KKLCFENPNYN-------- 301 Query: 254 KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 L DLLS +L + +R AL HP+ + ++I KM Sbjct: 302 -VLSPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSDKIYKM 344 >4AF3-A nrPDB Length = 292 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 79/289 (27%), Positives = 130/289 (44%), Gaps = 35/289 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELR 59 ++D+ +G+G +G VY R K + +VA+K + + + E+EGV REI + L Sbjct: 22 IDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH 81 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HPNI+ L + R+YLI E+ + + D + + ++ +++C Sbjct: 82 HPNILRLYNYFYDRRRIYLILEYAPRG--ELYKELQKSCTFDEQRTATIMEELADALMYC 139 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 H ++V+HRD+KP+NLL+ KG +K+ADFG + P TL Y PE++ G Sbjct: 140 HGKKVIHRDIKPENLLLGLKGELKIADFGWS--VHAPSLRRKTMCGTLDYLPPEMIEGRM 197 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 + VD+W IG + EL P F S + RI + Sbjct: 198 H-NEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV------------------DL 238 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 FP P DL+SK+L ++P++R+ HP+ Sbjct: 239 KFPASVPTG-----------AQDLISKLLRHNPSERLPLAQVSAHPWVR 276 >6O6Q-A nrPDB Length = 335 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 86/302 (28%), Positives = 156/302 (51%), Gaps = 23/302 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RH 60 E+Y + K+G G Y V+ G + V +K ++ ++ REIS+LK L Sbjct: 41 ENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVKRKK-----IKREISILKNLVDG 95 Query: 61 PNIVSLQDVLMQD--SRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 PNI+++ DV+ + LIFE ++ +D ++ Y+Y++L+ + + Sbjct: 96 PNIIAMLDVVREPQSKTPGLIFEHINN-----IDFRSLYPTFTDYDIRFYMYELLKALDY 150 Query: 119 CHSRRVLHRDLKPQNLLIDDKGT-IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 HS ++HRD+KP N++ID ++L D+GLA + P Y V + +++ PE+L+ Sbjct: 151 SHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLA-EYYHPGTEYNVRVASRYFKGPELLVD 209 Query: 178 SARYSTPVDIWSIGTIFAEL-ATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL-- 234 Y +D+WS G + A + K+P FHG S DQL +I R LG+ N + + E ++ Sbjct: 210 YRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISL 269 Query: 235 -QDYK----NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 ++Y+ +W ++ + + LDL+ ++L YD +R++ K A+ H YF+ Sbjct: 270 GEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHAYFDP 329 Query: 290 LD 291 + Sbjct: 330 IR 331 >4AN9-A nrPDB Length = 301 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 79/293 (26%), Positives = 128/293 (43%), Gaps = 34/293 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +D+ KI ++G G GVV+K HK +G V+A K I LE + + + IRE+ +L E P Sbjct: 9 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE-IKPAIRNQIIRELQVLHECNSP 67 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC-H 120 IV D + + E + + + ++ +++G+ + Sbjct: 68 YIVGFYGAFYSDGEISICMEHMDGGSLD--QVLKKAGRIPEQILGKVSIAVIKGLTYLRE 125 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 +++HRD+KP N+L++ +G IKL DFG++ + V T Y SPE L G+ Sbjct: 126 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLID--EMANEFVGTRSYMSPERLQGT-H 182 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 YS DIWS+G E+A + + + L DY Sbjct: 183 YSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELL----------------------DYIVN 220 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 P P L S V +L D ++K LI +PA+R K + H + D + Sbjct: 221 EP---PPKLPSAVFSL--EFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAE 268 >3EQC-A nrPDB Length = 360 Score = 221 bits (564), Expect = 2e-58, Method: Composition-based stats. Identities = 77/308 (25%), Positives = 128/308 (41%), Gaps = 22/308 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +D+ KI ++G G GVV+K HK +G V+A K I LE + + + IRE+ +L E P Sbjct: 33 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE-IKPAIRNQIIRELQVLHECNSP 91 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC-H 120 IV D + + E + + + ++ +++G+ + Sbjct: 92 YIVGFYGAFYSDGEISICMEHMDGGSLD--QVLKKAGRIPEQILGKVSIAVIKGLTYLRE 149 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 +++HRD+KP N+L++ +G IKL DFG++ + V T Y SPE L G+ Sbjct: 150 KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMSPERLQGT-H 206 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 YS DIWS+G E+A + + + E P + N Sbjct: 207 YSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLNK 266 Query: 241 F-----PKWKPGSLASHVKNLDE----------NGLDLLSKMLIYDPAKRISGKMALNHP 285 F P L ++ N D ++K LI +PA+R K + H Sbjct: 267 FGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHA 326 Query: 286 YFNDLDNQ 293 + D + Sbjct: 327 FIKRSDAE 334 >6CQF-A nrPDB Length = 297 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 76/285 (26%), Positives = 132/285 (46%), Gaps = 30/285 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + Y ++++G GTYG V+K R K +G +VA+K +++E +++ ST +EI +LK RH Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDD--VSTLQKEILILKTCRHA 73 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV+ + +L++ EF D + + ++LQG+ + HS Sbjct: 74 NIVAYHGSYLWLQKLWICMEFCGAG--SLQDIYQVTGSLSELQISYVCREVLQGLAYLHS 131 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV--LLGSA 179 ++ +HRD+K N+LI+D G ++LADFG++ G + + T ++ +PEV + Sbjct: 132 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKG 191 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 Y+ DIWS+G ELA +P + LF + ++ P P ++ + Sbjct: 192 GYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQP-----PRLKEKGKWSA 246 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNH 284 F + L P KR S L+H Sbjct: 247 AFHN-------------------FIKVTLTKSPKKRPSATKMLSH 272 >1KOB-A nrPDB Length = 387 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 73/295 (24%), Positives = 128/295 (43%), Gaps = 34/295 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 Y +E++G G +GVV++ K TG+V K I + T EIS++ +L HP + Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKY--TVKNEISIMNQLHHPKL 110 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQY-MDSSLVKSYLYQILQGIVFCHSR 122 ++L D + LI EFLS + D I Y M + V +Y+ Q +G+ H Sbjct: 111 INLHDAFEDKYEMVLILEFLSGG--ELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEH 168 Query: 123 RVLHRDLKPQNLLIDDKG--TIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 ++H D+KP+N++ + K ++K+ DFGLA P + T + +PE ++ Sbjct: 169 SIVHLDIKPENIMCETKKASSVKIIDFGLATKLN-PDEIVKVTTATAEFAAPE-IVDREP 226 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 D+W+IG + L + F G+ +++ L + R W E Sbjct: 227 VGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKR-------CDWEFDE-------- 271 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIK 295 ++ D + +L +P KR++ AL HP+ + + Sbjct: 272 ----------DAFSSVSPEAKDFIKNLLQKEPRKRLTVHDALEHPWLKGDHSNLT 316 >3PPZ-A nrPDB Length = 309 Score = 221 bits (563), Expect = 3e-58, Method: Composition-based stats. Identities = 76/273 (27%), Positives = 124/273 (45%), Gaps = 18/273 (6%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D EKIG G++G V++ G VA+K + + + +RE++++K LRHPN Sbjct: 38 DLNIKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPN 95 Query: 63 IVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 IV + Q L ++ E+LS L + L + +D S Y + +G+ + H+ Sbjct: 96 IVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHN 155 Query: 122 RR--VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 R ++HRDLK NLL+D K T+K+ DFGL+R T + +PEVL Sbjct: 156 RNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEP 215 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIF---RALGTPNNEVWPEVESLQD 236 + D++S G I ELAT + + + + + + L P N ++ Sbjct: 216 S-NEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEG 274 Query: 237 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLI 269 P WK S A+ +DLL ++ Sbjct: 275 CWTNEP-WKRPSFATI--------MDLLRPLIK 298 >6BDL-A nrPDB Length = 347 Score = 218 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 122/301 (40%), Gaps = 40/301 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHK-TTGQVVAMKKIRLESEEEGVPSTAIR-EISLLKEL 58 + D+ I+ +G G +G V + K + AMK ++ + IR E +++ Sbjct: 33 LSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGA 92 Query: 59 RHPNIVSLQDVLMQDSRLYLIFE-FLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 IV L LY++ E L +L L + S + Y +++ Sbjct: 93 HSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILR---DRGSFEDSTTRFYTACVVEAFA 149 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 + HS+ +++RDLKP+NL++D +G KL DFG A+ G + +T T Y +PE++L Sbjct: 150 YLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWT-FCGTPEYVAPEIILN 208 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 D WS+G + EL T P F G + I R + Sbjct: 209 KGH-DISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGI----------------- 250 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALNHPYFNDLDN 292 + K + +N +L+ K+ +P++R+ K H +F + Sbjct: 251 ----------DMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNW 300 Query: 293 Q 293 + Sbjct: 301 E 301 >3FME-A nrPDB Length = 290 Score = 218 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 68/293 (23%), Positives = 120/293 (40%), Gaps = 34/293 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +D I ++G G YGVV K RH +GQ++A+K+IR + + ++ + P Sbjct: 7 DDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCP 66 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCH 120 V+ L ++ +++ E + L K+ I GQ + ++ I++ + H Sbjct: 67 FTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLH 126 Query: 121 SR-RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL---L 176 S+ V+HRD+KP N+LI+ G +K+ DFG++ + + Y +PE + L Sbjct: 127 SKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDV-AKDIDAGCKPYMAPERINPEL 185 Query: 177 GSARYSTPVDIWSIGTIFAELA-TKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 YS DIWS+G ELA + P + QL ++ Sbjct: 186 NQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE----------------- 228 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 S +D S+ L + +R + + HP+F Sbjct: 229 ----------EPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 271 >6FYV-A nrPDB Length = 337 Score = 218 bits (556), Expect = 2e-57, Method: Composition-based stats. Identities = 82/331 (24%), Positives = 127/331 (38%), Gaps = 49/331 (14%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKT-TGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH- 60 Y ++ +GEG +G V + G VA+K ++ A EI +L+ L Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVK---NVGRYREAARSEIQVLEHLNST 71 Query: 61 -PN----IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 PN V + + + ++FE L + ++ ++ YQI Q Sbjct: 72 DPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKE-NSFLPFQIDHIRQMAYQICQS 130 Query: 116 IVFCHSRRVLHRDLKPQNLLIDD-------------------KGTIKLADFGLARAFGIP 156 I F H ++ H DLKP+N+L IK+ DFG A Sbjct: 131 INFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY---D 187 Query: 157 IRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRI 216 ++ V T YR+PEV+L +S P D+WSIG I E +F + L + Sbjct: 188 DEHHSTLVSTRHYRAPEVILALG-WSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMM 246 Query: 217 FRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHV---------------KNLDENGL 261 R LG + + + + + W S A E Sbjct: 247 ERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLF 306 Query: 262 DLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 DL+ +ML YDP +RI+ AL HP+F+ L Sbjct: 307 DLVRRMLEYDPTQRITLDEALQHPFFDLLKK 337 >3NYO-A nrPDB Length = 576 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 66/294 (22%), Positives = 125/294 (42%), Gaps = 33/294 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGV-PSTAIREISLLKELRHPN 62 + + +G+G +G V + + TG++ A KK+ + ++ + A+ E +L+++ Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRF 245 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 +VSL L L+ ++ K+ + Y +I G+ H Sbjct: 246 VVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRE 305 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 R+++RDLKP+N+L+DD G I+++D GLA + V T+ Y +PEV+ RY+ Sbjct: 306 RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI-KGRVGTVGYMAPEVVKNE-RYT 363 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 D W++G + E+ + F Q + + E ++ P Sbjct: 364 FSPDWWALGCLLYEMIAGQSPFQ------QRKKKIKR------------EEVERLVKEVP 405 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALNHPYFNDLD 291 + + + L S++L DPA+R+ S + HP F L+ Sbjct: 406 E-------EYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLN 452 >5FET-A nrPDB Length = 847 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 84/298 (28%), Positives = 128/298 (42%), Gaps = 38/298 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR-EISLLKELR 59 M + IG GT+G V HK T A+K + S I+ E + E Sbjct: 532 MHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITAEND 591 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HP I+ L + Y + E ++ + D+I + + YL I+ I + Sbjct: 592 HPFIIRLVRTFKDSNCFYFLTELVTGG--ELYDAIRKLGLLSKPQAQFYLGSIILAIEYL 649 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 H R +++RDLKP+N+L+D +G +KL DFG A+ R YT V T Y +PEV+LG Sbjct: 650 HERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQ--GRAYT-LVGTPHYMAPEVILGKG 706 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 Y VDIW++G E F G+ + DQL IFR + T Sbjct: 707 -YGCTVDIWALGVCLYEFICGPLPF-GNDQEDQL-EIFRDILTGQ--------------L 749 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG-----KMALNHPYFNDLDN 292 TFP + D++ ++L+ ++L P RI K H +F + + Sbjct: 750 TFPDYVS----------DQDSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFFGNFNW 797 >4MD7-E nrPDB Length = 391 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 84/299 (28%), Positives = 154/299 (51%), Gaps = 24/299 (8%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH- 60 +DY + K+G G Y V++ + T + + ++ + REI +L+ LR Sbjct: 37 DDYQLVRKLGRGKYSEVFEAINITNNEK-----VVVKILKPVKKKKIKREIKILENLRGG 91 Query: 61 PNIVSLQDVLMQD--SRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 PNI++L D++ L+FE ++ D Q + ++ Y+Y+IL+ + + Sbjct: 92 PNIITLADIVKDPVSRTPALVFEHVNNT-----DFKQLYQTLTDYDIRFYMYEILKALDY 146 Query: 119 CHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 CHS ++HRD+KP N++ID + ++L D+GLA F P + Y V + +++ PE+L+ Sbjct: 147 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 205 Query: 178 SARYSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 236 Y +D+WS+G + A + +K P FHG DQL RI + LGT + + + +++ Sbjct: 206 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 265 Query: 237 Y--------KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 +++ +W+ + + + LD L K+L YD R++ + A+ HPYF Sbjct: 266 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 324 >2FO0-A nrPDB Length = 495 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 68/282 (24%), Positives = 128/282 (45%), Gaps = 36/282 (12%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D T K+G G YG VY+G K VA+K ++ ++ E ++E +++KE++HPN Sbjct: 218 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---VEEFLKEAAVMKEIKHPN 274 Query: 63 IVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +V L V ++ Y+I EF++ +L YL Q +++ ++ QI + + Sbjct: 275 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNR-QEVNAVVLLYMATQISSAMEYLEK 333 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEVVTLWYRSPEVLLGSAR 180 + +HR+L +N L+ + +K+ADFGL+R G + + + +PE L + Sbjct: 334 KNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL-AYNK 392 Query: 181 YSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 +S D+W+ G + E+AT + G + Q++ + +DY+ Sbjct: 393 FSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLE----------------KDYRM 435 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 P+ P E +L+ ++P+ R S Sbjct: 436 ERPEGCP-----------EKVYELMRACWQWNPSDRPSFAEI 466 >2WQN-A nrPDB Length = 310 Score = 217 bits (553), Expect = 5e-57, Method: Composition-based stats. Identities = 74/278 (26%), Positives = 120/278 (43%), Gaps = 31/278 (11%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRL-ESEEEGVPSTAIREISLLKELRHP 61 ++ +KIG G + VY+ G VA+KK+++ + + + I+EI LLK+L HP Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHP 92 Query: 62 NIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYM-DSSLVKSYLYQILQGIVFC 119 N++ ++D+ L ++ E DL + + + + V Y Q+ + Sbjct: 93 NVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHM 152 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 HSRRV+HRD+KP N+ I G +KL D GL R F V T +Y SPE + + Sbjct: 153 HSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENG 212 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDS-EIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 Y+ DIWS+G + E+A + F+GD + L + P Sbjct: 213 -YNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPL------------- 258 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI 276 + E L++ + DP KR Sbjct: 259 -------------PSDHYSEELRQLVNMCINPDPEKRP 283 >4XEY-B nrPDB Length = 408 Score = 217 bits (553), Expect = 5e-57, Method: Composition-based stats. Identities = 69/282 (24%), Positives = 128/282 (45%), Gaps = 36/282 (12%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D T K+G G YG VY+G K VA+K ++ ++ E ++E +++KE++HPN Sbjct: 126 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---VEEFLKEAAVMKEIKHPN 182 Query: 63 IVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +V L V ++ Y+I EF++ +L YL Q +++ ++ QI + + Sbjct: 183 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNR-QEVNAVVLLYMATQISSAMEYLEK 241 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEVVTLWYRSPEVLLGSAR 180 + +HRDL +N L+ + +K+ADFGL+R G + + + +PE L + Sbjct: 242 KNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL-AYNK 300 Query: 181 YSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 +S D+W+ G + E+AT + G + Q++ + +DY+ Sbjct: 301 FSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLE----------------KDYRM 343 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 P+ P E +L+ ++P+ R S Sbjct: 344 ERPEGCP-----------EKVYELMRACWQWNPSDRPSFAEI 374 >4TNB-A nrPDB Length = 590 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 64/294 (21%), Positives = 123/294 (41%), Gaps = 33/294 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRHPN 62 + + +G+G +G V + + TG++ A K++ + ++ S A+ E +L+++ Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQF 245 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 +V+L L L+ ++ K+ + Y +IL G+ H Sbjct: 246 VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHE 305 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 ++RDLKP+N+L+DD G I+++D GLA + V T+ Y +PEVL + RY Sbjct: 306 NTVYRDLKPENILLDDYGHIRISDLGLAVKI-PEGDLIRGRVGTVGYMAPEVL-NNQRYG 363 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 D W +G + E+ + F G E + + R + +E+ + Y + F Sbjct: 364 LSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRV----------LETEEVYSHKF- 412 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYFNDLD 291 E + +L D +R+ HP+F +++ Sbjct: 413 --------------SEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMN 452 >3FXW-A nrPDB Length = 336 Score = 215 bits (549), Expect = 1e-56, Method: Composition-based stats. Identities = 72/298 (24%), Positives = 111/298 (37%), Gaps = 42/298 (14%) Query: 2 EDYTKIE-KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 +DY + +G G G V + H+ TGQ A+K + + + Sbjct: 28 DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHH------WQASGG 81 Query: 61 PNIVSLQDVLMQ----DSRLYLIFEFLSMDLKKYLDSIPPG--QYMDSSLVKSYLYQILQ 114 P+IV + DV L +I E + + I Q + I Sbjct: 82 PHIVCILDVYENMHHGKRCLLIIMECMEGG--ELFSRIQERGDQAFTEREAAEIMRDIGT 139 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRS 171 I F HS + HRD+KP+NLL +KL DFG A+ T +Y + Sbjct: 140 AIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKE--TTQNALQTPCYTPYYVA 197 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PEVL G +Y D+WS+G I L P F+ ++ G + Sbjct: 198 PEVL-GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNT------------GQAISPGMKRR 244 Query: 232 ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 L Y P+W + E+ L+ +L DP +R++ +NHP+ N Sbjct: 245 IRLGQYGFPNPEW---------SEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQ 293 >6BXI-A nrPDB Length = 333 Score = 215 bits (547), Expect = 2e-56, Method: Composition-based stats. Identities = 74/333 (22%), Positives = 118/333 (35%), Gaps = 70/333 (21%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR-EISLLKELR 59 +ED+ ++ IG G +G V + K TG V AMK +R E IR E +L E Sbjct: 5 LEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD 64 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 +V + LYLI EFL + + + + Y+ + + I Sbjct: 65 SLWVVKMFYSFQDKLNLYLIMEFLPGG--DMMTLLMKKDTLTEEETQFYIAETVLAIDSI 122 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV-------------------- 159 H +HRD+KP NLL+D KG +KL+DFGL R Sbjct: 123 HQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMN 182 Query: 160 ---------------YTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLF 204 V T Y +PEV + + Y+ D WS+G I E+ P F Sbjct: 183 SKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-YNKLCDWWSLGVIMYEMLIGYPPF 241 Query: 205 HGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLL 264 ++ + ++ WK + E DL+ Sbjct: 242 CSETPQETYKKVMN-------------------------WKETLTFPPEVPISEKAKDLI 276 Query: 265 SK-MLIYDPAKRISG---KMALNHPYFNDLDNQ 293 + ++ RI + ++ +F +D + Sbjct: 277 LRFCCEWEH--RIGAPGVEEIKSNSFFEGVDWE 307 >2PVN-A nrPDB Length = 352 Score = 215 bits (547), Expect = 2e-56, Method: Composition-based stats. Identities = 81/306 (26%), Positives = 144/306 (47%), Gaps = 22/306 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +DY + K+G G Y V++G + + K I + L P Sbjct: 52 DDYEVVRKVGRGKYSEVFEGINVNNNE----KCIIKILKPVKKKKIKREIKILQNLCGGP 107 Query: 62 NIVSLQDVL--MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 NIV L D++ LIFE+++ K L + ++ Y+Y++L+ + +C Sbjct: 108 NIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVL-----YPTLTDYDIRYYIYELLKALDYC 162 Query: 120 HSRRVLHRDLKPQNLLIDDK-GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 HS+ ++HRD+KP N++ID + ++L D+GLA F P + Y V + +++ PE+L+ Sbjct: 163 HSQGIMHRDVKPHNVMIDHELRKLRLIDWGLA-EFYHPGKEYNVRVASRYFKGPELLVDL 221 Query: 179 ARYSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 Y +D+WS+G +FA + +K P F+G DQL +I + LGT + ++ Sbjct: 222 QDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELD 281 Query: 238 --------KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 +++ W A + + +D L K+L YD +R++ A+ HPYF Sbjct: 282 PQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQQ 341 Query: 290 LDNQIK 295 + Sbjct: 342 VRAAEN 347 >6HMD-A nrPDB Length = 365 Score = 214 bits (545), Expect = 4e-56, Method: Composition-based stats. Identities = 82/308 (26%), Positives = 155/308 (50%), Gaps = 24/308 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +DY + K+G G Y V++ + T + ++ ++ + RE+ +L+ LR Sbjct: 53 DDYQLVRKLGRGKYSEVFEAINITNNE-----RVVVKILKPVKKKKIKREVKILENLRGG 107 Query: 62 -NIVSLQDVLMQD--SRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 NI+ L D + L+FE+++ D Q + ++ Y+Y++L+ + + Sbjct: 108 TNIIKLIDTVKDPVSKTPALVFEYINNT-----DFKQLYQILTDFDIRFYMYELLKALDY 162 Query: 119 CHSRRVLHRDLKPQNLLIDDK-GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 CHS+ ++HRD+KP N++ID + ++L D+GLA F P + Y V + +++ PE+L+ Sbjct: 163 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA-EFYHPAQEYNVRVASRYFKGPELLVD 221 Query: 178 SARYSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTPN--------NEVW 228 Y +D+WS+G + A + ++ P FHG DQL RI + LGT + Sbjct: 222 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 281 Query: 229 PEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 + +++ +W+ + + + LDLL K+L YD +R++ K A+ HPYF Sbjct: 282 DPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 341 Query: 289 DLDNQIKK 296 + + + Sbjct: 342 PVVKEQSQ 349 >6NPU-A nrPDB Length = 298 Score = 213 bits (543), Expect = 7e-56, Method: Composition-based stats. Identities = 69/282 (24%), Positives = 128/282 (45%), Gaps = 36/282 (12%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D T K+G G YG VY+G K VA+K ++ ++ E ++E +++KE++HPN Sbjct: 27 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTME---VEEFLKEAAVMKEIKHPN 83 Query: 63 IVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +V L V ++ Y+I EF++ +L YL Q +++ ++ QI + + Sbjct: 84 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNR-QEVNAVVLLYMATQISSAMEYLEK 142 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEVVTLWYRSPEVLLGSAR 180 + +HRDL +N L+ + +K+ADFGL+R G + + + +PE L + Sbjct: 143 KNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL-AYNK 201 Query: 181 YSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 +S D+W+ G + E+AT + G + Q++ + +DY+ Sbjct: 202 FSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYELLE----------------KDYRM 244 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 P+ P E +L+ ++P+ R S Sbjct: 245 ERPEGCP-----------EKVYELMRACWQWNPSDRPSFAEI 275 >3C51-A nrPDB Length = 543 Score = 213 bits (542), Expect = 9e-56, Method: Composition-based stats. Identities = 67/298 (22%), Positives = 116/298 (38%), Gaps = 34/298 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGV-PSTAIREISLLKELRHPN 62 + +G G +G V+ + K TG++ A KK+ + ++ A+ E +L ++ Sbjct: 187 FLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRF 246 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKY--LDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 IVSL + L L+ ++ +Y + Y QI+ G+ H Sbjct: 247 IVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLH 306 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 R +++RDLKP+N+L+DD G ++++D GLA T + +PE+LLG Sbjct: 307 QRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEE- 365 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 Y VD +++G E+ + F E E + + + T Sbjct: 366 YDFSVDYFALGVTLYEMIAARGPFRARGEK--------------VENKELKQRVLEQAVT 411 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALNHPYFNDLDNQ 293 +P D +L DP KR+ S HP F D+ + Sbjct: 412 YPD-----------KFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWR 458 >4WNO-A nrPDB Length = 287 Score = 212 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 80/297 (26%), Positives = 134/297 (45%), Gaps = 43/297 (14%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKT-TGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++++ + IG G + VV+KGRH+ VA+K I ++ + +EI +LKEL+H Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQT-LLGKEIKILKELKHE 77 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 NIV+L D + +YL+ E+ + DL YL ++ + + ++ +L QI + H Sbjct: 78 NIVALYDFQEMANSVYLVMEYCNGGDLADYLHAM---RTLSEDTIRLFLQQIAGAMRLLH 134 Query: 121 SRRVLHRDLKPQNLLIDDKG---------TIKLADFGLARAFGIPIRVYTHEVVTLWYRS 171 S+ ++HRDLKPQN+L+ + +K+ADFG AR + T + Y + Sbjct: 135 SKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT-LCGSPMYMA 193 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PEV++ S Y D+WSIGTI + T K F S D + Sbjct: 194 PEVIM-SQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD---------------LRLFY 237 Query: 232 ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 E + T P+ L + L + + R+ +HP+ + Sbjct: 238 EKNKTLVPTIPRETSAPLRQLLLALLQR-----------NHKDRMDFDEFFHHPFLD 283 >1NY3-A nrPDB Length = 400 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 116/298 (38%), Gaps = 43/298 (14%) Query: 1 MEDYTKI-EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLL-KEL 58 ++DY + +G G G V + +K T + A+K + A RE+ L + Sbjct: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRAS 112 Query: 59 RHPNIVSLQDVLMQ----DSRLYLIFEFLSMDLKKYLDSIPPG--QYMDSSLVKSYLYQI 112 + P+IV + DV L ++ E L + I Q + I Sbjct: 113 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQAFTEREASEIMKSI 170 Query: 113 LQGIVFCHSRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAFGIPIRVYTHEVVTLWY 169 + I + HS + HRD+KP+NLL +KL DFG A+ T T +Y Sbjct: 171 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYY 229 Query: 170 RSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 +PEVL G +Y D+WS+G I L P F+ + G + Sbjct: 230 VAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPGMK 276 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 + Y+ P+W + E L+ +L +P +R++ +NHP+ Sbjct: 277 TRIRMGQYEFPNPEW---------SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 >3KA0-A nrPDB Length = 320 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 116/298 (38%), Gaps = 43/298 (14%) Query: 1 MEDYTKI-EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLL-KEL 58 ++DY + +G G G V + +K T + A+K + A RE+ L + Sbjct: 14 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRAS 66 Query: 59 RHPNIVSLQDVLMQ----DSRLYLIFEFLSMDLKKYLDSIPPG--QYMDSSLVKSYLYQI 112 + P+IV + DV L ++ E L + I Q + I Sbjct: 67 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQAFTEREASEIMKSI 124 Query: 113 LQGIVFCHSRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAFGIPIRVYTHEVVTLWY 169 + I + HS + HRD+KP+NLL +KL DFG A+ T T +Y Sbjct: 125 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTEPCYTPYY 183 Query: 170 RSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 +PEVL G +Y D+WS+G I L P F+ + G + Sbjct: 184 VAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPGMK 230 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 + Y+ P+W + E L+ +L +P +R++ +NHP+ Sbjct: 231 TRIRMGQYEFPNPEW---------SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 279 >2XNP-A nrPDB Length = 279 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 82/297 (27%), Positives = 128/297 (43%), Gaps = 38/297 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 EDY + IG G+YG K R K+ G+++ K++ S E + E++LL+EL+HP Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65 Query: 62 NIVSLQDVLMQ--DSRLYLIFEFL-SMDLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIV 117 NIV D ++ ++ LY++ E+ DL + QY+D V + Q+ + Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125 Query: 118 FCHS-----RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSP 172 CH VLHRDLKP N+ +D K +KL DFGLAR V T +Y SP Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSP 185 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 E + Y+ DIWS+G + EL P F S+ + +I Sbjct: 186 EQ-MNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKI---------------- 228 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 + G + +++++ML R S + L +P + Sbjct: 229 ------------REGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLILE 273 >3TT0-A nrPDB Length = 382 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 71/285 (24%), Positives = 137/285 (48%), Gaps = 32/285 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQ-------VVAMKKIRLESEEEGVPSTAIREISL 54 + + +GEG +G V + VA+K ++ ++ E+ + S I E+ + Sbjct: 69 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL-SDLISEMEM 127 Query: 55 LKEL-RHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLD-------------SIPPGQY 99 +K + +H NI++L QD LY+I E+ S +L++YL S P + Sbjct: 128 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQ 187 Query: 100 MDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG--IPI 157 + S + S YQ+ +G+ + S++ +HRDL +N+L+ + +K+ADFGLAR Sbjct: 188 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 247 Query: 158 RVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRI 216 + T+ + + + +PE L Y+ D+WS G + E+ T + G +++LF++ Sbjct: 248 KKTTNGRLPVKWMAPEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKL 305 Query: 217 FR---ALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDE 258 + + P+N ++D + P +P + V++LD Sbjct: 306 LKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRP-TFKQLVEDLDR 349 >6EII-A nrPDB Length = 352 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 85/299 (28%), Positives = 154/299 (51%), Gaps = 24/299 (8%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH- 60 +DY + K+G G Y V++ + T + V ++ + REI +L+ LR Sbjct: 60 DDYQLVRKLGRGKYSEVFEAINITNNEKV-----VVKILKPVKKKKIKREIKILENLRGG 114 Query: 61 PNIVSLQDVLMQD--SRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 PNI++L D++ L+FE ++ D Q + ++ Y+Y+IL+ + + Sbjct: 115 PNIITLADIVKDPVSRTPALVFEHVNNT-----DFKQLYQTLTDYDIRFYMYEILKALDY 169 Query: 119 CHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 CHS ++HRD+KP N++ID + ++L D+GLA F P + Y V + +++ PE+L+ Sbjct: 170 CHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA-EFYHPGQEYNVRVASRYFKGPELLVD 228 Query: 178 SARYSTPVDIWSIGTIFAELATKK-PLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 236 Y +D+WS+G + A + +K P FHG DQL RI + LGT + + + +++ Sbjct: 229 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 288 Query: 237 Y--------KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 +++ +W+ + + + LD L K+L YD R++ + A+ HPYF Sbjct: 289 DPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF 347 >2OZA-A nrPDB Length = 356 Score = 211 bits (537), Expect = 3e-55, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 116/298 (38%), Gaps = 43/298 (14%) Query: 1 MEDYTKI-EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLL-KEL 58 ++DY + +G G G V + +K T + A+K + A RE+ L + Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRAS 68 Query: 59 RHPNIVSLQDVLMQ----DSRLYLIFEFLSMDLKKYLDSIPPG--QYMDSSLVKSYLYQI 112 + P+IV + DV L ++ E L + I Q + I Sbjct: 69 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQAFTEREASEIMKSI 126 Query: 113 LQGIVFCHSRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAFGIPIRVYTHEVVTLWY 169 + I + HS + HRD+KP+NLL +KL DFG A+ T T +Y Sbjct: 127 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYY 185 Query: 170 RSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 +PEVL G +Y D+WS+G I L P F+ + G + Sbjct: 186 VAPEVL-GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPGMK 232 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 + Y+ P+W + E L+ +L +P +R++ +NHP+ Sbjct: 233 TRIRMGQYEFPNPEW---------SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 281 >4FR4-A nrPDB Length = 384 Score = 211 bits (537), Expect = 3e-55, Method: Composition-based stats. Identities = 65/297 (21%), Positives = 132/297 (44%), Gaps = 35/297 (11%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELR 59 + + + IG+G++G V + T ++ AMK + + + E +E+ +++ L Sbjct: 14 FDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLE 73 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 HP +V+L + ++++ + L DL+ +L + VK ++ +++ + + Sbjct: 74 HPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQ---NVHFKEETVKLFICELVMALDY 130 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 ++R++HRD+KP N+L+D+ G + + DF +A ++ T T Y +PE+ Sbjct: 131 LQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQI-TTMAGTKPYMAPEMFSSR 189 Query: 179 A--RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 236 YS VD WS+G EL + +H S ++ Sbjct: 190 KGAGYSFAVDWWSLGVTAYELLRGRRPYH----------------------IRSSTSSKE 227 Query: 237 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS-GKMALNHPYFNDLDN 292 +TF ++ ++ + + LL K+L +P +R S N PY ND++ Sbjct: 228 IVHTF----ETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINW 280 >2H8H-A nrPDB Length = 535 Score = 210 bits (536), Expect = 4e-55, Method: Composition-based stats. Identities = 67/290 (23%), Positives = 122/290 (42%), Gaps = 40/290 (13%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 K+G+G +G V+ G T + VA+K ++ + P ++E ++K+LRH +V L Sbjct: 274 KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 329 Query: 69 VLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHR 127 V+ ++ +Y++ E++S L +L G+Y+ + QI G+ + +HR Sbjct: 330 VVSEE-PIYIVTEYMSKGSLLDFLKG-ETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 387 Query: 128 DLKPQNLLIDDKGTIKLADFGLARAFGI-PIRVYTHEVVTLWYRSPEVLLGSARYSTPVD 186 DL+ N+L+ + K+ADFGLAR + + +PE L R++ D Sbjct: 388 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSD 446 Query: 187 IWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWK 245 +WS G + EL T + + G + L ++ R P Sbjct: 447 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP-------------------- 486 Query: 246 PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGK--MALNHPYFNDLDNQ 293 E+ DL+ + +P +R + + A YF + Q Sbjct: 487 --------PECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 528 >5A46-A nrPDB Length = 386 Score = 210 bits (536), Expect = 5e-55, Method: Composition-based stats. Identities = 71/285 (24%), Positives = 137/285 (48%), Gaps = 32/285 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQ-------VVAMKKIRLESEEEGVPSTAIREISL 54 + + +GEG +G V + VA+K ++ ++ E+ + S I E+ + Sbjct: 40 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL-SDLISEMEM 98 Query: 55 LKEL-RHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLD-------------SIPPGQY 99 +K + +H NI++L QD LY+I E+ S +L++YL S P + Sbjct: 99 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 158 Query: 100 MDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG--IPI 157 + S + S YQ+ +G+ + S++ +HRDL +N+L+ + +K+ADFGLAR Sbjct: 159 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 218 Query: 158 RVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRI 216 + T+ + + + +PE L Y+ D+WS G + E+ T + G +++LF++ Sbjct: 219 KKTTNGRLPVKWMAPEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKL 276 Query: 217 FR---ALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDE 258 + + P+N ++D + P +P + V++LD Sbjct: 277 LKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRP-TFKQLVEDLDR 320 >4UY9-A nrPDB Length = 323 Score = 210 bits (535), Expect = 6e-55, Method: Composition-based stats. Identities = 71/261 (27%), Positives = 121/261 (46%), Gaps = 24/261 (9%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVP--STAIREISLLKELRH 60 + T E IG G +G VY+ G VA+K R + +E+ +E L L+H Sbjct: 10 ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 67 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNI++L+ V +++ L L+ EF L+ + G+ + ++ ++ QI +G+ + H Sbjct: 68 PNIIALRGVCLKEPNLCLVMEFARGGP---LNRVLSGKRIPPDILVNWAVQIARGMNYLH 124 Query: 121 SRR---VLHRDLKPQNLLI--------DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWY 169 ++HRDLK N+LI +K+ DFGLAR + ++ T + Sbjct: 125 DEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM--SAAGTYAW 182 Query: 170 RSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR---ALGTPNNE 226 +PEV+ S +S D+WS G + EL T + F G + + + AL P+ Sbjct: 183 MAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTC 241 Query: 227 VWPEVESLQDYKNTFPKWKPG 247 P + ++D N P +P Sbjct: 242 PEPFAKLMEDCWNPDPHSRPS 262 >4E93-A nrPDB Length = 377 Score = 210 bits (534), Expect = 7e-55, Method: Composition-based stats. Identities = 66/280 (23%), Positives = 118/280 (42%), Gaps = 36/280 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ED E+IG G +G V+ GR + +VA+K R E+ + + ++E +LK+ HP Sbjct: 114 EDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCR-ETLPPDLKAKFLQEARILKQYSHP 172 Query: 62 NIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 NIV L V Q +Y++ E + D +L + G + + + G+ + Sbjct: 173 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT--EGARLRVKTLLQMVGDAAAGMEYLE 230 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTH--EVVTLWYRSPEVLLGS 178 S+ +HRDL +N L+ +K +K++DFG++R + + V + + +PE L Sbjct: 231 SKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEAL-NY 289 Query: 179 ARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 RYS+ D+WS G + E + + S + + P E+ P Sbjct: 290 GRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP-------- 341 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS 277 + L+ + Y+P +R S Sbjct: 342 --------------------DAVFRLMEQCWAYEPGQRPS 361 >4GS6-A nrPDB Length = 315 Score = 210 bits (534), Expect = 7e-55, Method: Composition-based stats. Identities = 87/308 (28%), Positives = 135/308 (43%), Gaps = 51/308 (16%) Query: 1 MEDYTKIEK---IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKE 57 M DY +IE +G G +GVV K + + + VA+K+I E E I E+ L Sbjct: 5 MIDYKEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQI----ESESERKAFIVELRQLSR 58 Query: 58 LRHPNIVSLQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 + HPNIV L + + + L+ E+ L L P Y ++ S+ Q QG+ Sbjct: 59 VNHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGV 116 Query: 117 VFCHS---RRVLHRDLKPQNLLIDDKGTI-KLADFGLARAFGIPIRVYTHEVVTLWYRSP 172 + HS + ++HRDLKP NLL+ GT+ K+ DFG A T+ + + +P Sbjct: 117 AYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDI---QTHMTNNKGSAAWMAP 173 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 EV GS YS D++S G I E+ T++ F D FRI A+ Sbjct: 174 EVFEGS-NYSEKCDVFSWGIILWEVITRRKPF--DEIGGPAFRIMWAV------------ 218 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKM---ALNH--PYF 287 G+ +KNL + L+++ DP++R S + + H YF Sbjct: 219 ------------HNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYF 266 Query: 288 NDLDNQIK 295 D ++ Sbjct: 267 PGADEPLQ 274 >3DTC-A nrPDB Length = 271 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 70/261 (26%), Positives = 120/261 (45%), Gaps = 24/261 (9%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVP--STAIREISLLKELRH 60 + T E IG G +G VY+ G VA+K R + +E+ +E L L+H Sbjct: 8 ELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKH 65 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNI++L+ V +++ L L+ EF L+ + G+ + ++ ++ QI +G+ + H Sbjct: 66 PNIIALRGVCLKEPNLCLVMEFARGGP---LNRVLSGKRIPPDILVNWAVQIARGMNYLH 122 Query: 121 SRR---VLHRDLKPQNLLI--------DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWY 169 ++HRDLK N+LI +K+ DFGLAR + ++ + Sbjct: 123 DEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM--SAAGAYAW 180 Query: 170 RSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR---ALGTPNNE 226 +PEV+ S +S D+WS G + EL T + F G + + + AL P+ Sbjct: 181 MAPEVIRASM-FSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTC 239 Query: 227 VWPEVESLQDYKNTFPKWKPG 247 P + ++D N P +P Sbjct: 240 PEPFAKLMEDCWNPDPHSRPS 260 >3GQL-A nrPDB Length = 326 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 71/285 (24%), Positives = 137/285 (48%), Gaps = 32/285 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQ-------VVAMKKIRLESEEEGVPSTAIREISL 54 + + +GEG +G V + VA+K ++ ++ E+ + S I E+ + Sbjct: 28 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL-SDLISEMEM 86 Query: 55 LKEL-RHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLD-------------SIPPGQY 99 +K + +H NI++L QD LY+I E+ S +L++YL S P + Sbjct: 87 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 146 Query: 100 MDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG--IPI 157 + S + S YQ+ +G+ + S++ +HRDL +N+L+ + +K+ADFGLAR Sbjct: 147 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 206 Query: 158 RVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRI 216 + T+ + + + +PE L Y+ D+WS G + E+ T + G +++LF++ Sbjct: 207 KKTTNGRLPVKWMAPEALFDRI-YTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKL 264 Query: 217 FR---ALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDE 258 + + P+N ++D + P +P + V++LD Sbjct: 265 LKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRP-TFKQLVEDLDR 308 >4UYA-A nrPDB Length = 340 Score = 208 bits (530), Expect = 2e-54, Method: Composition-based stats. Identities = 73/263 (27%), Positives = 122/263 (46%), Gaps = 24/263 (9%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEE--GVPSTAIREISLLKEL 58 E E IG G +G VY+ + GQ VA+K R + E++ + RE L L Sbjct: 25 FERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVRREARLFAML 82 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 RHPNI+ L+ V +Q L L+ EF L+ G+ + ++ ++ QI +G+++ Sbjct: 83 RHPNIIELRGVCLQQPHLCLVLEFARGG---ALNRALAGRRIPPHVLVNWAVQIARGMLY 139 Query: 119 CHSRR---VLHRDLKPQNLLIDD--------KGTIKLADFGLARAFGIPIRVYTHEVVTL 167 H +LHRDLK N+L+ + T+K+ DFGLAR + ++ T Sbjct: 140 LHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMAT--AGAY 197 Query: 168 WYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIF---RALGTPN 224 + +PEV+ S+ +S DIWS G + EL T + + G + + + L P+ Sbjct: 198 AWMAPEVI-KSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPS 256 Query: 225 NEVWPEVESLQDYKNTFPKWKPG 247 P + +++ P +P Sbjct: 257 TCPEPFAKLMKECWQQDPHIRPS 279 >2XYN-A nrPDB Length = 292 Score = 208 bits (530), Expect = 2e-54, Method: Composition-based stats. Identities = 63/281 (22%), Positives = 113/281 (40%), Gaps = 36/281 (12%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D T K+G G YG VY G K VA+K ++ ++ E ++E +++KE++HPN Sbjct: 33 DITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME---VEEFLKEAAVMKEIKHPN 89 Query: 63 IVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +V L V + Y++ E++ +L YL + + + ++ QI + + Sbjct: 90 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREE-VTAVVLLYMATQISSAMEYLEK 148 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEVVTLWYRSPEVLLGSAR 180 + +HRDL +N L+ + +K+ADFGL+R G + + + +PE L Sbjct: 149 KNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL-AYNT 207 Query: 181 YSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 +S D+W+ G + E+AT + G + + E P Sbjct: 208 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP---------- 257 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKM 280 +L+ + PA R S Sbjct: 258 ------------------PKVYELMRACWKWSPADRPSFAE 280 >6GVJ-A nrPDB Length = 429 Score = 208 bits (530), Expect = 2e-54, Method: Composition-based stats. Identities = 80/308 (25%), Positives = 134/308 (43%), Gaps = 45/308 (14%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN- 62 Y+ +++IG G V++ ++ Q+ A+K + LE + + EI+ L +L+ + Sbjct: 146 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 63 -IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 I+ L D + D +Y++ E ++DL +L + +D KSY +L+ + H Sbjct: 205 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKK---KKSIDPWERKSYWKNMLEAVHTIHQ 261 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--VYTHEVVTLWYRSPEVLLG-- 177 ++H DLKP N LI G +KL DFG+A V +V T+ Y PE + Sbjct: 262 HGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMS 320 Query: 178 --------SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 ++ S D+WS+G I + K F I+Q+ ++ A+ PN+E+ Sbjct: 321 SSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKL-HAIIDPNHEI-- 375 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 FP L D+L L DP +RIS L HPY Sbjct: 376 ----------EFPDIPEKDLQ-----------DVLKCCLKRDPKQRISIPELLAHPYVQI 414 Query: 290 LDNQIKKM 297 + + +M Sbjct: 415 QTHPVNQM 422 >5XVU-A nrPDB Length = 332 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 92/305 (30%), Positives = 156/305 (51%), Gaps = 24/305 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH- 60 Y ++KIG G Y V+ G + A ++ + REI +L+ L Sbjct: 31 NRYEIMKKIGRGKYSEVFNGYDTECNRPCA-----IKVLKPVKKKKIKREIKILQNLNGG 85 Query: 61 PNIVSLQDVLMQD--SRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 PNI+ L D++ LIFE+++ +D ++ Y+YQIL+ + + Sbjct: 86 PNIIKLLDIVKDPVTKTPSLIFEYINN-----IDFKTLYPKFTDKDIRYYIYQILKALDY 140 Query: 119 CHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 CHS+ ++HRD+KP N++ID + I+L +GLA F P + Y V + +Y+ PE+L+ Sbjct: 141 CHSQGIMHRDVKPHNIMIDHENRQIRLISWGLA-EFYHPGQEYNVRVASRYYKGPELLID 199 Query: 178 SARYSTPVDIWSIGTIFA-ELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ- 235 Y +DIWS+G + A + K+P F G DQL +I + LGT + + + +++ Sbjct: 200 LQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIKL 259 Query: 236 --DYKNTFPKWKPGSLA-----SHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 Y N +++ + S++ + +DL+ KMLIYD AKRI+ K A+ HPYF Sbjct: 260 KPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEHPYFR 319 Query: 289 DLDNQ 293 ++ + Sbjct: 320 EVREE 324 >6F3F-A nrPDB Length = 455 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 66/290 (22%), Positives = 122/290 (42%), Gaps = 40/290 (13%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 K+G+G +G V+ G T + VA+K ++ + P ++E ++K+LRH +V L Sbjct: 194 KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 249 Query: 69 VLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHR 127 V+ ++ +Y++ E+++ L +L G+Y+ + QI G+ + +HR Sbjct: 250 VVSEE-PIYIVTEYMNKGSLLDFLKG-ETGKYLRLPQLVDMSAQIASGMAYVERMNYVHR 307 Query: 128 DLKPQNLLIDDKGTIKLADFGLARAFGI-PIRVYTHEVVTLWYRSPEVLLGSARYSTPVD 186 DL+ N+L+ + K+ADFGLAR + + +PE L R++ D Sbjct: 308 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSD 366 Query: 187 IWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWK 245 +WS G + EL T + + G + L ++ R P Sbjct: 367 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP-------------------- 406 Query: 246 PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGK--MALNHPYFNDLDNQ 293 E+ DL+ + +P +R + + A YF + Q Sbjct: 407 --------PECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 448 >1S9I-A nrPDB Length = 354 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 78/316 (24%), Positives = 131/316 (41%), Gaps = 38/316 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +D+ +I ++G G GVV K +H+ +G ++A K I LE + + + IRE+ +L E P Sbjct: 16 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLE-IKPAIRNQIIRELQVLHECNSP 74 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC-H 120 IV D + + E + + + + ++ +L+G+ + Sbjct: 75 YIVGFYGAFYSDGEISICMEHMDGGSLD--QVLKEAKRIPEEILGKVSIAVLRGLAYLRE 132 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 +++HRD+KP N+L++ +G IKL DFG++ + V T Y +PE L G+ Sbjct: 133 KHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDS--MANSFVGTRSYMAPERLQGT-H 189 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP----------- 229 YS DIWS+G ELA + + L IF E P Sbjct: 190 YSVQSDIWSMGLSLVELAVGRYPIPPPDAKE-LEAIFGRPVVDGEEGEPHSISPRPRPPG 248 Query: 230 --------------EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKR 275 + L DY P K + + + ++K LI +PA+R Sbjct: 249 RPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPN-----GVFTPDFQEFVNKCLIKNPAER 303 Query: 276 ISGKMALNHPYFNDLD 291 KM NH + + Sbjct: 304 ADLKMLTNHTFIKRSE 319 >6QAU-A nrPDB Length = 280 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 69/219 (31%), Positives = 114/219 (52%), Gaps = 15/219 (6%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKT-TGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 +Y+K + +G G + VV++GRH+ T VA+K I ++ + +EI +LKEL+H Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQI-LLGKEIKILKELQHE 70 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV+L DV + ++L+ E+ + D + + ++ +L+QI + HS Sbjct: 71 NIVALYDVQELPNSVFLVMEYCNGG--DLADYLQAKGTLSEDTIRVFLHQIAAAMRILHS 128 Query: 122 RRVLHRDLKPQNLLID---------DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSP 172 + ++HRDLKPQN+L+ IK+ADFG AR + + + Y +P Sbjct: 129 KGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNM-MAADLCGSPMYMAP 187 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEID 211 EV++ S Y D+WSIGT+ + KP F +S D Sbjct: 188 EVIM-SQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD 225 >6E2O-A nrPDB Length = 295 Score = 207 bits (527), Expect = 5e-54, Method: Composition-based stats. Identities = 72/295 (24%), Positives = 117/295 (39%), Gaps = 38/295 (12%) Query: 3 DYTKIE-----KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKE 57 DY E +G+GTYG+VY GR + +A+K+I + EI+L K Sbjct: 18 DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKH 75 Query: 58 LRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 L+H NIV ++ + + E + L L S + + Y QIL+G+ Sbjct: 76 LKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGL 135 Query: 117 VFCHSRRVLHRDLKPQNLLIDD-KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 + H +++HRD+K N+LI+ G +K++DFG ++ TL Y +PE++ Sbjct: 136 KYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEII 195 Query: 176 -LGSARYSTPVDIWSIGTIFAELATKKPLFHG-DSEIDQLFRIFRALGTPNNEVWPEVES 233 G Y DIWS+G E+AT KP F+ +F++ P Sbjct: 196 DKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHP---------- 245 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 +++ + K DP KR L + Sbjct: 246 -----------------EIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLK 283 >5H2U-A nrPDB Length = 267 Score = 207 bits (527), Expect = 5e-54, Method: Composition-based stats. Identities = 66/284 (23%), Positives = 118/284 (41%), Gaps = 35/284 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E++T K+G G +G V++G K Q VA+K I ++ EI +K+LRH Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWKDRVQ-VAIKVISRDNL--LHQQMLQSEIQAMKKLRHK 62 Query: 62 NIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 +I++L V+ +Y+I E ++ L + L + + S + +Q+ +G+ + Sbjct: 63 HILALYAVVSVGDPVYIITELMAKGSLLELLRD-SDEKVLPVSELLDIAWQVAEGMCYLE 121 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 S+ +HRDL +N+L+ + K+ DFGLAR + + + + +PE L Sbjct: 122 SQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEAL-SRGH 180 Query: 181 YSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 YST D+WS G + E+ + + + G S + R+ P P Sbjct: 181 YSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECP---------- 230 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 + L+ DP +R + K Sbjct: 231 ------------------PSVHKLMLTCWCRDPEQRPTFKALRE 256 >5UNP-A nrPDB Length = 369 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 83/333 (24%), Positives = 134/333 (40%), Gaps = 49/333 (14%) Query: 2 EDYTKIEKIGEGTYGVVYKGR-HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 E Y + +GEGT+G V + H+ G VA+K I+ E A EI++L+++ Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK---NVEKYKEAARLEINVLEKINE 90 Query: 61 PN------IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 + V + D + + FE L + +L Y V+ +Q+ Q Sbjct: 91 KDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPY-PIHQVRHMAFQLCQ 149 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKG-------------------TIKLADFGLARAFGI 155 + F H ++ H DLKP+N+L + +++ DFG A Sbjct: 150 AVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATF--- 206 Query: 156 PIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFR 215 ++ V T YR+PEV+L +S P D+WSIG I E LF + L Sbjct: 207 DHEHHSTIVSTRHYRAPEVILELG-WSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAM 265 Query: 216 IFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHV---------KNLDENG------ 260 + R LG + + + + + W + A + L Sbjct: 266 MERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQL 325 Query: 261 LDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 DL+ ML Y+PAKR++ AL HP+F L + Sbjct: 326 FDLIESMLEYEPAKRLTLGEALQHPFFARLRAE 358 >5UUU-A nrPDB Length = 547 Score = 205 bits (523), Expect = 1e-53, Method: Composition-based stats. Identities = 70/304 (23%), Positives = 121/304 (39%), Gaps = 41/304 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEE-EGVPSTAIREISLLKEL- 58 M D++ IG G +G VY R TG++ AMK + + + + + A+ E +L + Sbjct: 197 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 256 Query: 59 --RHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 P IV + +L I + ++ DL +L + ++ Y +I+ G Sbjct: 257 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ---HGVFSEADMRFYAAEIILG 313 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 + H+R V++RDLKP N+L+D+ G ++++D GLA F + V T Y +PEVL Sbjct: 314 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS--KKKPHASVGTHGYMAPEVL 371 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 Y + D +S+G + +L F D Sbjct: 372 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD------------------------ 407 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALNHPYFNDL 290 K+ + + LL +L D +R+ + P+F L Sbjct: 408 --KHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 465 Query: 291 DNQI 294 D Q+ Sbjct: 466 DWQM 469 >2PSQ-A nrPDB Length = 370 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 72/285 (25%), Positives = 138/285 (48%), Gaps = 32/285 (11%) Query: 2 EDYTKIEKIGEGTYGVVYK----GRHKTTGQV---VAMKKIRLESEEEGVPSTAIREISL 54 + T + +GEG +G V G K + VA+K ++ ++ E+ + S + E+ + Sbjct: 81 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL-SDLVSEMEM 139 Query: 55 LKEL-RHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPP-------------GQY 99 +K + +H NI++L QD LY+I E+ S +L++YL + P + Sbjct: 140 MKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 199 Query: 100 MDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG--IPI 157 M + S YQ+ +G+ + S++ +HRDL +N+L+ + +K+ADFGLAR Sbjct: 200 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 259 Query: 158 RVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRI 216 + T+ + + + +PE L Y+ D+WS G + E+ T + G +++LF++ Sbjct: 260 KKTTNGRLPVKWMAPEALFDRV-YTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKL 317 Query: 217 FR---ALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDE 258 + + P N ++D + P +P + V++LD Sbjct: 318 LKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP-TFKQLVEDLDR 361 >4AT3-A nrPDB Length = 299 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 66/288 (22%), Positives = 123/288 (42%), Gaps = 29/288 (10%) Query: 3 DYTKIEKIGEGTYGVVYKGRH-----KTTGQVVAMKKIRLESEEEGVPSTAIREISLLKE 57 + ++GEG +G V+ + +VA+K ++ + RE LL Sbjct: 14 NIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK--DASDNARKDFHREAELLTN 71 Query: 58 LRHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSI----------PPGQYMDSSLVK 106 L+H +IV V ++ L ++FE++ DL K+L + P + S + Sbjct: 72 LQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQML 131 Query: 107 SYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI--RVYTHEV 164 QI G+V+ S+ +HRDL +N L+ + +K+ DFG++R RV H + Sbjct: 132 HIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTM 191 Query: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRI--FRALG 221 + + + PE ++ +++T D+WS+G + E+ T K ++ S + + I R L Sbjct: 192 LPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQ 250 Query: 222 TPNNEVWPEVESLQDYKNTFPKWKPG-----SLASHVKNLDENGLDLL 264 P E + P + +L ++ LD+L Sbjct: 251 RPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDIL 298 >4OTD-A nrPDB Length = 341 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 62/304 (20%), Positives = 125/304 (41%), Gaps = 44/304 (14%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRL-ESEEEGVPSTAIREISLLKEL- 58 +ED+ + +G G +G V + +G++ A+K ++ + + + E +L + Sbjct: 11 LEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVT 70 Query: 59 --RHPNIVSLQDVLMQDSRLYLIFEF-LSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 HP +V+L + + E+ DL ++ S Y ++ G Sbjct: 71 SAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS----DVFSEPRAIFYSACVVLG 126 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 + F H ++++RDLK NLL+D +G +K+ADFGL + + T + +PEVL Sbjct: 127 LQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL 186 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 ++ Y+ VD W +G + E+ + F GD E + I Sbjct: 187 TDTS-YTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIV------------------ 227 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYFNDL 290 + + +P++ L + ++ ++L +P +R+ + P+F L Sbjct: 228 NDEVRYPRF-----------LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTL 276 Query: 291 DNQI 294 + Sbjct: 277 GWEA 280 >3PVW-A nrPDB Length = 695 Score = 204 bits (520), Expect = 3e-53, Method: Composition-based stats. Identities = 70/304 (23%), Positives = 121/304 (39%), Gaps = 41/304 (13%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEE-EGVPSTAIREISLLKEL- 58 M D++ IG G +G VY R TG++ AMK + + + + + A+ E +L + Sbjct: 188 MNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVS 247 Query: 59 --RHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 P IV + +L I + ++ DL +L + ++ Y +I+ G Sbjct: 248 TGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQ---HGVFSEADMRFYAAEIILG 304 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 + H+R V++RDLKP N+L+D+ G ++++D GLA F + V T Y +PEVL Sbjct: 305 LEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS--KKKPHASVGTHGYMAPEVL 362 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 Y + D +S+G + +L F D Sbjct: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD------------------------ 398 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALNHPYFNDL 290 K+ + + LL +L D +R+ + P+F L Sbjct: 399 --KHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSL 456 Query: 291 DNQI 294 D Q+ Sbjct: 457 DWQM 460 >4EBW-A nrPDB Length = 304 Score = 204 bits (520), Expect = 3e-53, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 126/302 (41%), Gaps = 48/302 (15%) Query: 2 EDYTKIEKIGEGTYGVVYKGRH---KTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL 58 E IGEG +G V++G + + VA+K + + V ++E +++ Sbjct: 38 ERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCK-NCTSDSVREKFLQEALTMRQF 96 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 HP+IV L V+ ++ +++I E + +L+ +L +D + + Y YQ+ + Sbjct: 97 DHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQ--VRKYSLDLASLILYAYQLSTALA 153 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHE-VVTLWYRSPEVLL 176 + S+R +HRD+ +N+L+ +KL DFGL+R + + + + +PE + Sbjct: 154 YLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESI- 212 Query: 177 GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 R+++ D+W G E+ F G D + RI P Sbjct: 213 NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLP------------ 260 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIK 295 P P +L S L++K YDP++R P F +L Q+ Sbjct: 261 -----MPPNCPPTLYS-----------LMTKCWAYDPSRR---------PRFTELKAQLS 295 Query: 296 KM 297 + Sbjct: 296 TI 297 >2DQ7-X nrPDB Length = 283 Score = 204 bits (519), Expect = 4e-53, Method: Composition-based stats. Identities = 62/281 (22%), Positives = 120/281 (42%), Gaps = 38/281 (13%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E I+++G G +G V+ G + VA+K ++ + P + + E ++K+L+H Sbjct: 9 ESLQLIKRLGNGQFGEVWMGTWNGNTK-VAIKTLKPGTMS---PESFLEEAQIMKKLKHD 64 Query: 62 NIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 +V L V+ ++ +Y++ E+++ L +L G+ + + Q+ G+ + Sbjct: 65 KLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKD-GEGRALKLPNLVDMAAQVAAGMAYIE 122 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGI-PIRVYTHEVVTLWYRSPEVLLGSA 179 +HRDL+ N+L+ + K+ADFGLAR + + +PE L Sbjct: 123 RMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-YG 181 Query: 180 RYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 R++ D+WS G + EL T + + G + + L ++ R Y+ Sbjct: 182 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERG-----------------YR 224 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGK 279 P+ P SL L+ DP +R + + Sbjct: 225 MPCPQDCPISLHE-----------LMIHCWKKDPEERPTFE 254 >5MJB-A nrPDB Length = 305 Score = 203 bits (517), Expect = 7e-53, Method: Composition-based stats. Identities = 60/257 (23%), Positives = 110/257 (42%), Gaps = 18/257 (7%) Query: 5 TKIEKIGEGTYGVVYKGRHKTTGQ---VVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E IG G +G VYKGR K G+ VA+K ++ E + E S++ + H Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLK-AGYSEKQRRDFLSEASIMGQFDHR 87 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NI+ L+ V+ + + +I EF+ GQ + L I G+ + Sbjct: 88 NIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQ-FTVIQLVGMLRGIAAGMKYLSE 146 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP--IRVYTHEVV---TLWYRSPEVLL 176 +HRDL +N+L++ K++DFGL+R YT + + + +PE + Sbjct: 147 MNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAI- 205 Query: 177 GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWP------ 229 ++++ D+WS G + E+ + + + S D + I + P P Sbjct: 206 AYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQL 265 Query: 230 EVESLQDYKNTFPKWKP 246 ++ Q +N+ P++ Sbjct: 266 MLDCWQKDRNSRPRFAE 282 >5SYS-A nrPDB Length = 286 Score = 203 bits (516), Expect = 9e-53, Method: Composition-based stats. Identities = 67/290 (23%), Positives = 121/290 (41%), Gaps = 40/290 (13%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 K+G+G +G + G T + VA+K ++ + P ++E ++K+LRH +V L Sbjct: 25 KLGQGCFGECWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 80 Query: 69 VLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHR 127 V+ ++ +Y++ E++S L +L G+Y+ + QI G+ + +HR Sbjct: 81 VVSEE-PIYIVTEYMSKGSLLDFLKGEM-GKYLRLPQLVDMAAQIASGMAYVERMNYVHR 138 Query: 128 DLKPQNLLIDDKGTIKLADFGLARAFGI-PIRVYTHEVVTLWYRSPEVLLGSARYSTPVD 186 DL+ N+L+ + K+ADFGLAR + + +PE L R++ D Sbjct: 139 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSD 197 Query: 187 IWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWK 245 +WS G + EL T + + G + L ++ R P Sbjct: 198 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP-------------------- 237 Query: 246 PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGK--MALNHPYFNDLDNQ 293 E+ DL+ + DP +R + + A YF + Q Sbjct: 238 --------PECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQ 279 >3HMP-A nrPDB Length = 342 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 80/308 (25%), Positives = 134/308 (43%), Gaps = 45/308 (14%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN- 62 Y+ +++IG G V++ ++ Q+ A+K + LE + + EI+ L +L+ + Sbjct: 58 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 63 -IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 I+ L D + D +Y++ E ++DL +L + +D KSY +L+ + H Sbjct: 117 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKK---KKSIDPWERKSYWKNMLEAVHTIHQ 173 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--VYTHEVVTLWYRSPEVLLG-- 177 ++H DLKP N LI G +KL DFG+A V +V T+ Y PE + Sbjct: 174 HGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMS 232 Query: 178 --------SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 ++ S D+WS+G I + K F I+Q+ ++ A+ PN+E+ Sbjct: 233 SSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKL-HAIIDPNHEI-- 287 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 FP L D+L L DP +RIS L HPY Sbjct: 288 ----------EFPDIPEKDLQ-----------DVLKCCLKRDPKQRISIPELLAHPYVQI 326 Query: 290 LDNQIKKM 297 + + +M Sbjct: 327 QTHPVNQM 334 >3A4O-X nrPDB Length = 286 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 58/253 (22%), Positives = 116/253 (45%), Gaps = 15/253 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E ++++G G +G V+ G + + + VA+K ++ + + E +L+K L+H Sbjct: 13 ESIKLVKRLGAGQFGEVWMGYYNNSTK-VAVKTLKPGTMS---VQAFLEEANLMKTLQHD 68 Query: 62 NIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 +V L V+ ++ +Y+I E+++ L +L S G+ + L+ + QI +G+ + Sbjct: 69 KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLI-DFSAQIAEGMAYIE 127 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGI-PIRVYTHEVVTLWYRSPEVLLGSA 179 + +HRDL+ N+L+ + K+ADFGLAR + + +PE + Sbjct: 128 RKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAI-NFG 186 Query: 180 RYSTPVDIWSIGTIFAELAT-KKPLFHGDSEID------QLFRIFRALGTPNNEVWPEVE 232 ++ D+WS G + E+ T K + G + D Q +R+ R P+ Sbjct: 187 CFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKM 246 Query: 233 SLQDYKNTFPKWK 245 ++ P + Sbjct: 247 CWKEKAEERPTFD 259 >4P5Q-A nrPDB Length = 361 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 57/257 (22%), Positives = 116/257 (45%), Gaps = 18/257 (7%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQV---VAMKKIRLESEEEGVPSTAIREISLLKELR 59 + + + +G G +G V GR K + VA+K +++ E+ + E S++ + Sbjct: 34 NISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQ-RRDFLGEASIMGQFD 92 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 HPNI+ L+ V+ + + ++ E++ + L +L + L I G+ + Sbjct: 93 HPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQ--FTVIQLVGMLRGIASGMKY 150 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEVV--TLWYRSPEVL 175 +HRDL +N+LI+ K++DFGL+R P YT + + SPE + Sbjct: 151 LSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAI 210 Query: 176 LGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSE------IDQLFRIFRALGTPNNEVW 228 ++++ D+WS G + E+ + + + S +D+ +R+ + P Sbjct: 211 -AYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQ 269 Query: 229 PEVESLQDYKNTFPKWK 245 ++ Q +N PK++ Sbjct: 270 LMLDCWQKDRNNRPKFE 286 >3RAW-A nrPDB Length = 381 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 85/333 (25%), Positives = 135/333 (40%), Gaps = 49/333 (14%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQ-VVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 E Y + +GEGT+G V + G+ VA+K IR A EI++LK+++ Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIR---NVGKYREAARLEINVLKKIKE 107 Query: 61 PN------IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 + V + D + + FE L + ++L Q V+ YQ+ Sbjct: 108 KDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKE-NNFQPYPLPHVRHMAYQLCH 166 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDD-------------------KGTIKLADFGLARAFGI 155 + F H ++ H DLKP+N+L + +I++ADFG A Sbjct: 167 ALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATF--- 223 Query: 156 PIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFR 215 +T V T YR PEV+L ++ P D+WSIG I E LF + L Sbjct: 224 DHEHHTTIVATRHYRPPEVILELG-WAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVM 282 Query: 216 IFRALGTPNNEVWPEVESLQDYKNTFPKWKPGS-----LASHVKNLDE----------NG 260 + + LG + + + + W S + + K L Sbjct: 283 MEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQL 342 Query: 261 LDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQ 293 DL+ +ML +DPA+RI+ AL HP+F L + Sbjct: 343 FDLMRRMLEFDPAQRITLAEALLHPFFAGLTPE 375 >4EQM-A nrPDB Length = 294 Score = 202 bits (514), Expect = 1e-52, Method: Composition-based stats. Identities = 82/265 (30%), Positives = 125/265 (47%), Gaps = 8/265 (3%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPSTAIREISLLKELRH 60 E Y ++K+G G VY VA+K I + E+E RE+ +L H Sbjct: 11 ERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSSQLSH 70 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 NIVS+ DV +D YL+ E++ L +Y++S P + ++ QIL GI Sbjct: 71 QNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHGP---LSVDTAINFTNQILDGIKHA 127 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV-VTLWYRSPEVLLGS 178 H R++HRD+KPQN+LID T+K+ DFG+A+A T+ V T+ Y SPE G Sbjct: 128 HDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQAKGE 187 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 A DI+SIG + E+ +P F+G++ + + + PN + Q Sbjct: 188 AT-DECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQD-SVPNVTTDVRKDIPQSLS 245 Query: 239 NTFPKWKPGSLASHVKNLDENGLDL 263 N + A+ K + E DL Sbjct: 246 NVILRATEKDKANRYKTIQEMKDDL 270 >5B2L-A nrPDB Length = 324 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 62/298 (20%), Positives = 119/298 (39%), Gaps = 35/298 (11%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 + D + ++G GT G V+K R + TG V+A+K++R +E + +LK Sbjct: 16 INDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDC 75 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC- 119 P IV + ++ +++ E + +K + + ++ I++ + + Sbjct: 76 PYIVQCFGTFITNTDVFIAMELMGTSAEKLKKRMQ--GPIPERILGKMTVAIVKALYYLK 133 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL--- 176 V+HRD+KP N+L+D++G IKL DFG++ + + T Y +PE + Sbjct: 134 EKHGVIHRDVKPSNILLDERGQIKLCDFGISGRL-VDSKAKTRSAGCAAYMAPERIDPPD 192 Query: 177 -GSARYSTPVDIWSIGTIFAELATKKPLF-HGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 Y D+WS+G ELAT + + + ++ + L ++ + Sbjct: 193 PTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQ---------------- 236 Query: 235 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDN 292 P PG + + + L D KR L H + + Sbjct: 237 -----EEPPLLPGHM-----GFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYET 284 >2J0K-A nrPDB Length = 656 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 126/302 (41%), Gaps = 48/302 (15%) Query: 2 EDYTKIEKIGEGTYGVVYKGRH---KTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL 58 E IGEG +G V++G + + VA+K + + V ++E +++ Sbjct: 390 ERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCK-NCTSDSVREKFLQEALTMRQF 448 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 HP+IV L V+ ++ +++I E + +L+ +L +D + + Y YQ+ + Sbjct: 449 DHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQ--VRKFSLDLASLILYAYQLSTALA 505 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHE-VVTLWYRSPEVLL 176 + S+R +HRD+ +N+L+ +KL DFGL+R + + + + +PE + Sbjct: 506 YLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESI- 564 Query: 177 GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 R+++ D+W G E+ F G D + RI P Sbjct: 565 NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLP------------ 612 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIK 295 P P +L S L++K YDP++R P F +L Q+ Sbjct: 613 -----MPPNCPPTLYS-----------LMTKCWAYDPSRR---------PRFTELKAQLS 647 Query: 296 KM 297 + Sbjct: 648 TI 649 >2WTK-C nrPDB Length = 305 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 75/300 (25%), Positives = 131/300 (43%), Gaps = 37/300 (12%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTT--GQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 Y + +GEG+YG V + T + V + K + + +EI LL+ LRH Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRH 65 Query: 61 PNIVSLQDVL--MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 N++ L DVL + ++Y++ E+ +++ LDS+ P + Y Q++ G+ + Sbjct: 66 KNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV-PEKRFPVCQAHGYFCQLIDGLEY 124 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG--IPIRVYTHEVVTLWYRSPEVLL 176 HS+ ++H+D+KP NLL+ GT+K++ G+A A + ++ PE+ Sbjct: 125 LHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIAN 184 Query: 177 GSARYS-TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 G +S VDIWS G + T F GD+ ++++F +G + + Sbjct: 185 GLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDN----IYKLFENIGKGSYAIP------- 233 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIK 295 + DLL ML Y+PAKR S + H +F + Sbjct: 234 ------------------GDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAE 275 >4K33-A nrPDB Length = 325 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 65/284 (22%), Positives = 135/284 (47%), Gaps = 32/284 (11%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQ-------VVAMKKIRLESEEEGVPSTAIREISLL 55 T + +GEG +G V + VA+K ++ ++ ++ + S + E+ ++ Sbjct: 37 RLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDL-SDLVSEMEMM 95 Query: 56 KEL-RHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLD-------------SIPPGQYM 100 K + +H NI++L Q LY++ E+ + +L+++L S PP + + Sbjct: 96 KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQL 155 Query: 101 DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG--IPIR 158 + S YQ+ +G+ + S++ +HRDL +N+L+ + +K+ADFGLAR + Sbjct: 156 TFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYK 215 Query: 159 VYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIF 217 T+ + + + +PE L Y+ D+WS G + E+ T + G +++LF++ Sbjct: 216 ETTNGRLPVKWMAPEALFDRV-YTHQSDVWSFGVLLWEIFTLGGSPYPGI-PVEELFKLL 273 Query: 218 R---ALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDE 258 + + P N +++ + P +P + V++LD Sbjct: 274 KEGHRMDKPANCTHDLYMIMRECWHAAPSQRP-TFKQLVEDLDR 316 >4YHJ-A nrPDB Length = 584 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 61/294 (20%), Positives = 122/294 (41%), Gaps = 33/294 (11%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGV-PSTAIREISLLKELRHPN 62 + +G+G +G V + + TG++ A KK++ + ++ + A+ E +L++++ Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRF 246 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 +VSL L L+ ++ K+ D Y ++ G+ Sbjct: 247 VVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRE 306 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 R+++RDLKP+N+L+DD+G I+++D GLA RV V T+ Y +PEV+ + +Y+ Sbjct: 307 RIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVR-GRVGTVGYMAPEVV-NNEKYT 364 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 D W +G + E+ F E + + + + Sbjct: 365 FSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRI---------------------- 402 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI-----SGKMALNHPYFNDLD 291 + + E+ + +L +P+KR+ HP F D++ Sbjct: 403 ---KNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDIN 453 >3V5Q-A nrPDB Length = 297 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 65/301 (21%), Positives = 116/301 (38%), Gaps = 53/301 (17%) Query: 3 DYTKIEKIGEGTYGVVYKGRH-----KTTGQVVAMKKIRLESEEEGVPSTAIREISLLKE 57 D ++GEG +G V+ +VA+K ++ + RE LL Sbjct: 16 DIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTL--AARKDFQREAELLTN 73 Query: 58 LRHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPP-------------GQYMDSS 103 L+H +IV V L ++FE++ DL K+L + P + S Sbjct: 74 LQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLS 133 Query: 104 LVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI--RVYT 161 + QI G+V+ S+ +HRDL +N L+ +K+ DFG++R RV Sbjct: 134 QMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGG 193 Query: 162 HEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRAL 220 H ++ + + PE ++ +++T D+WS G I E+ T K + S + + I + Sbjct: 194 HTMLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGR 252 Query: 221 GTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKM 280 V P+ D++ +P +R++ K Sbjct: 253 VLERPRVCPK----------------------------EVYDVMLGCWQREPQQRLNIKE 284 Query: 281 A 281 Sbjct: 285 I 285 >4IAN-A nrPDB Length = 358 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 87/318 (27%), Positives = 133/318 (41%), Gaps = 45/318 (14%) Query: 11 GEGTYGVVYKGRHKT-TGQVVAMKKIRLESEEEGVPSTAIREISLLKELR------HPNI 63 G+G + V + R Q VA+K IR E + T ++E+ LK+L + Sbjct: 39 GQGVFSNVVRARDNARANQEVAVKIIR---NNELMQKTGLKELEFLKKLNDADPDDKFHC 95 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 + L L L+FE LSM+L++ L + V+SY Q+ + Sbjct: 96 LRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCN 155 Query: 124 VLHRDLKPQNLLIDDKGTI-KLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 +LH D+KP N+L+++ TI KL DFG A T +V+ +YR+PE+++G + Y Sbjct: 156 ILHADIKPDNILVNESKTILKLCDFGSASHVADND--ITPYLVSRFYRAPEIIIGKS-YD 212 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG-TPNNEVWPEVESLQDYKNTF 241 +D+WS+G EL T K LF G + L G PN + V Q + Sbjct: 213 YGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNL 272 Query: 242 -----------------------PKWKPGSLASHVKNLDE-------NGLDLLSKMLIYD 271 P + + L E DLL ++L+ D Sbjct: 273 NFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLD 332 Query: 272 PAKRISGKMALNHPYFND 289 PAKRIS AL H + + Sbjct: 333 PAKRISINQALQHAFIQE 350 >5EG3-A nrPDB Length = 334 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 71/285 (24%), Positives = 137/285 (48%), Gaps = 32/285 (11%) Query: 2 EDYTKIEKIGEGTYGVVYK----GRHKTTGQV---VAMKKIRLESEEEGVPSTAIREISL 54 + T + +GEG +G V G K + VA+K ++ ++ E+ + S + E+ + Sbjct: 35 DKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL-SDLVSEMEM 93 Query: 55 LKEL-RHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPP-------------GQY 99 +K + +H NI++L QD LY+I + S +L++YL + P + Sbjct: 94 MKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQ 153 Query: 100 MDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI-- 157 M + S YQ+ +G+ + S++ +HRDL +N+L+ + +K+ADFGLAR Sbjct: 154 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFF 213 Query: 158 RVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRI 216 + T+ + + + +PE L Y+ D+WS G + E+ T + G +++LF++ Sbjct: 214 KETTNGRLPVKWMAPEALFDRV-YTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKL 271 Query: 217 FR---ALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDE 258 + + P N ++D + P +P + V++LD Sbjct: 272 LKEGHRMDKPANCTNELYMMMRDCWHAVPSQRP-TFKQLVEDLDR 315 >6CCF-A nrPDB Length = 290 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 70/317 (22%), Positives = 126/317 (39%), Gaps = 58/317 (18%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGV---------------- 44 + Y +IG+G YGVV +++ + AMK + + + Sbjct: 4 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQG 63 Query: 45 --------PSTAIREISLLKELRHPNIVSLQDVLMQ--DSRLYLIFEFLSMDLKKYLDSI 94 +EI++LK+L H N+V L +VL + LYL+F+ L + + Sbjct: 64 GPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGP---VMEV 120 Query: 95 PPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG 154 P + + YL ++ G+ + H ++++HRD+KP NLL+ D G +K+ADFG++ F Sbjct: 121 PCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 180 Query: 155 IPIRVYTHEVVTLWYRSPEVLLGSAR--YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQ 212 + T + +PE + S + +D+W+ G K F Sbjct: 181 GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF-------- 232 Query: 213 LFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDP 272 ++ + +++ FP+ + E DL+ KML +P Sbjct: 233 ----------IDDFILALHRKIKNEPVVFPE---------EPEISEELKDLILKMLDKNP 273 Query: 273 AKRISGKMALNHPYFND 289 RI HP+ Sbjct: 274 ETRIGVPDIKLHPWVTK 290 >5O2B-A nrPDB Length = 285 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 71/289 (24%), Positives = 121/289 (41%), Gaps = 41/289 (14%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 ++G G + VYKG T VA +++ + E +LK L+HPNIV D Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 82 Query: 69 VLMQ----DSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 + L+ E + S LK YL + M +++S+ QIL+G+ F H+R Sbjct: 83 SWESILKGKKCIVLVTELMTSGTLKTYLKRF---KVMKPKVLRSWCRQILKGLQFLHTRT 139 Query: 124 --VLHRDLKPQNLLIDD-KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 ++HRDLK N+ I G++K+ D GLA + T + +PE+ Sbjct: 140 PPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTS--FAKSVIGTPEFMAPEMY--EEH 195 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 Y VD+++ G E+AT + + Q++R + P Sbjct: 196 YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKP----------------- 238 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 AS K D +++ + + ++R+S + LNH +F + Sbjct: 239 ---------ASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 >5O2C-A nrPDB Length = 380 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 71/289 (24%), Positives = 121/289 (41%), Gaps = 41/289 (14%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 ++G G + VYKG T VA +++ + E +LK L+HPNIV D Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYD 91 Query: 69 VLMQ----DSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 + L+ E + S LK YL + M +++S+ QIL+G+ F H+R Sbjct: 92 SWESILKGKKCIVLVTELMTSGTLKTYLKRF---KVMKPKVLRSWCRQILKGLQFLHTRT 148 Query: 124 --VLHRDLKPQNLLIDD-KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 ++HRDLK N+ I G++K+ D GLA + T + +PE+ Sbjct: 149 PPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTS--FAKSVIGTPEFMAPEMY--EEH 204 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 Y VD+++ G E+AT + + Q++R + P Sbjct: 205 YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKP----------------- 247 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 AS K D +++ + + ++R+S + LNH +F + Sbjct: 248 ---------ASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 287 >2ZMD-A nrPDB Length = 390 Score = 200 bits (510), Expect = 4e-52, Method: Composition-based stats. Identities = 79/308 (25%), Positives = 133/308 (43%), Gaps = 45/308 (14%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN- 62 Y+ +++IG G V++ ++ Q+ A+K + LE + + EI+ L +L+ + Sbjct: 58 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 116 Query: 63 -IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 I+ L D + D +Y++ E ++DL +L + +D KSY +L+ + H Sbjct: 117 KIIRLYDYEITDQYIYMVMECGNIDLNSWLK---KKKSIDPWERKSYWKNMLEAVHTIHQ 173 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--VYTHEVVTLWYRSPEVLLG-- 177 ++H DLKP N LI G +KL DFG+A V +V + Y PE + Sbjct: 174 HGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMS 232 Query: 178 --------SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 ++ S D+WS+G I + K F I+Q+ ++ A+ PN+E+ Sbjct: 233 SSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKL-HAIIDPNHEI-- 287 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 FP L D+L L DP +RIS L HPY Sbjct: 288 ----------EFPDIPEKDLQ-----------DVLKCCLKRDPKQRISIPELLAHPYVQI 326 Query: 290 LDNQIKKM 297 + + +M Sbjct: 327 QTHPVNQM 334 >5X5O-A nrPDB Length = 310 Score = 200 bits (510), Expect = 4e-52, Method: Composition-based stats. Identities = 67/285 (23%), Positives = 119/285 (41%), Gaps = 45/285 (15%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 +D E G G++G VY+ + + + VA+KK+ +E +L L H Sbjct: 14 FDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK----------IEKEAEILSVLSH 63 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 NI+ V+++ ++ E+ S L Y++S + MD + ++ + +G+ + Sbjct: 64 RNIIQFYGVILEPPNYGIVTEYASLGSLYDYINS-NRSEEMDMDHIMTWATDVAKGMHYL 122 Query: 120 HSR---RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 H +V+HRDLK +N++I G +K+ DFG +R + V T + +PEV+ Sbjct: 123 HMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM--SLVGTFPWMAPEVI- 179 Query: 177 GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 236 S S D +S G + E+ T++ F G + + + ++ Sbjct: 180 QSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVE----------------KN 223 Query: 237 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 + T P P S A LL + D KR S K Sbjct: 224 ERLTIPSSCPRSFAE-----------LLHQCWEADAKKRPSFKQI 257 >5L6P-A nrPDB Length = 298 Score = 200 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 63/280 (22%), Positives = 118/280 (42%), Gaps = 24/280 (8%) Query: 5 TKIEKIGEGTYGVVYKGRHKTTGQV---VAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E IG G +G V +GR K G+ VA+K +++ E + E S++ + HP Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYT-ERQRRDFLSEASIMGQFDHP 80 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NI+ L+ V+ + + ++ EF+ + GQ + L I G+ + Sbjct: 81 NIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQ-FTVIQLVGMLRGIAAGMKYLSE 139 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP--IRVYTHEVV---TLWYRSPEVLL 176 +HRDL +N+L++ K++DFGL+R YT + + + +PE + Sbjct: 140 MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAI- 198 Query: 177 GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV--ES 233 ++++ D+WS G + E+ + + + S D + + + P P + Sbjct: 199 AYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQL 258 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPA 273 + D +P + V LD+ LI +PA Sbjct: 259 MLDCWVRDRNLRPK-FSQIVNTLDK---------LIRNPA 288 >3DKO-A nrPDB Length = 318 Score = 200 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 60/279 (21%), Positives = 113/279 (40%), Gaps = 22/279 (7%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQV---VAMKKIRLESEEEGVPSTAIREISLLKELRH 60 IG G +G V GR K G+ VA+K +++ E+ + E S++ + H Sbjct: 45 IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQ-RRDFLCEASIMGQFDH 103 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PN+V L+ V+ + + ++ EF+ GQ + L I G+ + Sbjct: 104 PNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQ-FTVIQLVGMLRGIAAGMRYLA 162 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR---VYTHEVVTLWYRSPEVLLG 177 +HRDL +N+L++ K++DFGL+R T + + + +PE + Sbjct: 163 DMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAI-Q 221 Query: 178 SARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPE--VESL 234 ++++ D+WS G + E+ + + + S D + I P P + + Sbjct: 222 YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLM 281 Query: 235 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPA 273 D +P E + +L KM+ +P Sbjct: 282 LDCWQKERAERPKF---------EQIVGILDKMI-RNPN 310 >5AP3-A nrPDB Length = 313 Score = 200 bits (509), Expect = 5e-52, Method: Composition-based stats. Identities = 80/308 (25%), Positives = 134/308 (43%), Gaps = 45/308 (14%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN- 62 Y+ +++IG G V++ ++ Q+ A+K + LE + + EI+ L +L+ + Sbjct: 30 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 88 Query: 63 -IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 I+ L D + D +Y++ E ++DL +L + +D KSY +L+ + H Sbjct: 89 KIIRLYDYEITDQYIYMVMECGNIDLNGWLKK---KKSIDPWERKSYWKNMLEAVHTIHQ 145 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--VYTHEVVTLWYRSPEVLLG-- 177 ++H DLKP N LI G +KL DFG+A V +V T+ Y PE + Sbjct: 146 HGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMS 204 Query: 178 --------SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 ++ S D+WS+G I + K F I+Q+ ++ A+ PN+E+ Sbjct: 205 SSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKL-HAIIDPNHEI-- 259 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 FP L D+L L DP +RIS L HPY Sbjct: 260 ----------EFPDIPEKDLQ-----------DVLKCCLKRDPKQRISIPELLAHPYVQI 298 Query: 290 LDNQIKKM 297 + + +M Sbjct: 299 QTHPVNQM 306 >2R2P-A nrPDB Length = 295 Score = 200 bits (509), Expect = 6e-52, Method: Composition-based stats. Identities = 58/256 (22%), Positives = 111/256 (43%), Gaps = 16/256 (6%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQV---VAMKKIRLESEEEGVPSTAIREISLLKELRH 60 T IG G +G V GR K G+ VA+K +++ E+ + E S++ + H Sbjct: 24 ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQ-RRDFLGEASIMGQFDH 82 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNI+ L+ V+ + + ++ E++ GQ + L I G+ + Sbjct: 83 PNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQ-FTVIQLVGMLRGISAGMKYLS 141 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEVV--TLWYRSPEVLLG 177 +HRDL +N+LI+ K++DFGL+R P YT + + +PE + Sbjct: 142 DMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAI-A 200 Query: 178 SARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWP------E 230 ++++ D+WS G + E+ + + + + D + + P+ P Sbjct: 201 FRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLM 260 Query: 231 VESLQDYKNTFPKWKP 246 ++ Q +N+ PK+ Sbjct: 261 LDCWQKERNSRPKFDE 276 >2PL0-A nrPDB Length = 289 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 60/249 (24%), Positives = 115/249 (46%), Gaps = 10/249 (4%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E +E++G G +G V+ G + + VA+K ++ S P + E +L+K+L+H Sbjct: 23 ETLKLVERLGAGQFGEVWMGYYNGHTK-VAVKSLKQGSMS---PDAFLAEANLMKQLQHQ 78 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +V L V+ Q+ +Y+I E++ P G + + + QI +G+ F Sbjct: 79 RLVRLYAVVTQE-PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEE 137 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGI-PIRVYTHEVVTLWYRSPEVLLGSAR 180 R +HRDL+ N+L+ D + K+ADFGLAR + + +PE + Sbjct: 138 RNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAI-NYGT 196 Query: 181 YSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRA--LGTPNNEVWPEVESLQDY 237 ++ D+WS G + E+ T + + G + + + + R + P+N + ++ Sbjct: 197 FTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLC 256 Query: 238 KNTFPKWKP 246 P+ +P Sbjct: 257 WKERPEDRP 265 >4XLV-A nrPDB Length = 328 Score = 200 bits (508), Expect = 7e-52, Method: Composition-based stats. Identities = 65/311 (20%), Positives = 123/311 (39%), Gaps = 52/311 (16%) Query: 2 EDYTKIEKIGEGTYGVVYKG--RHKTTGQ---VVAMKKIRLESEEEGVPSTAIREISLLK 56 E T + ++G+G++G+VY+G R G+ VA+K + ES + E S++K Sbjct: 39 EKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-ESASLRERIEFLNEASVMK 97 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDS-------SLVKSY 108 ++V L V+ + ++ E ++ DLK YL S+ P + + Sbjct: 98 GFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQM 157 Query: 109 LYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV--T 166 +I G+ + ++++ +HRDL +N ++ T+K+ DFG+ R Sbjct: 158 AAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLP 217 Query: 167 LWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNN 225 + + +PE L ++T D+WS G + E+ + + + G S L + Sbjct: 218 VRWMAPESLKD-GVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMD------- 269 Query: 226 EVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN-- 283 G N E DL+ ++P R + +N Sbjct: 270 ---------------------GGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLL 308 Query: 284 ----HPYFNDL 290 HP F ++ Sbjct: 309 KDDLHPSFPEV 319 >1JPA-A nrPDB Length = 312 Score = 200 bits (508), Expect = 7e-52, Method: Composition-based stats. Identities = 56/255 (21%), Positives = 111/255 (43%), Gaps = 18/255 (7%) Query: 5 TKIEKIGEGTYGVVYKGRHKTTGQV---VAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + IG G +G V G K G+ VA+K ++ E+ + E S++ + HP Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQ-RRDFLSEASIMGQFDHP 94 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 N++ L+ V+ + + + +I EF+ GQ + L I G+ + Sbjct: 95 NVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQ-FTVIQLVGMLRGIAAGMKYLAD 153 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP--IRVYTHEVV---TLWYRSPEVLL 176 +HRDL +N+L++ K++DFGL+R YT + + + +PE + Sbjct: 154 MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAI- 212 Query: 177 GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEID------QLFRIFRALGTPNNEVWP 229 ++++ D+WS G + E+ + + + + D Q +R+ + P+ Sbjct: 213 QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQL 272 Query: 230 EVESLQDYKNTFPKW 244 ++ Q +N PK+ Sbjct: 273 MLDCWQKDRNHRPKF 287 >1LUF-A nrPDB Length = 343 Score = 200 bits (508), Expect = 8e-52, Method: Composition-based stats. Identities = 62/283 (21%), Positives = 123/283 (43%), Gaps = 34/283 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHK-----TTGQVVAMKKIRLESEEEGVPSTAIREISLLK 56 + + IGEG +G V++ R +VA+K ++ E+ + + + RE +L+ Sbjct: 47 NNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASAD-MQADFQREAALMA 105 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPG------------------ 97 E +PNIV L V + L+FE+++ DL ++L S+ P Sbjct: 106 EFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSS 165 Query: 98 ---QYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG 154 + + Q+ G+ + R+ +HRDL +N L+ + +K+ADFGL+R Sbjct: 166 PGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIY 225 Query: 155 --IPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEID 211 + ++ + + + PE + RY+T D+W+ G + E+ + ++G + + Sbjct: 226 SADYYKADGNDAIPIRWMPPESIF-YNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEE 284 Query: 212 QLF--RIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASH 252 ++ R L P N ++ + P +P + H Sbjct: 285 VIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIH 327 >4CRS-A nrPDB Length = 341 Score = 199 bits (506), Expect = 1e-51, Method: Composition-based stats. Identities = 61/304 (20%), Positives = 123/304 (40%), Gaps = 44/304 (14%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRL----ESEEEGVPSTAIREISLLK 56 ++D+ + G +G V +K T ++ A+K ++ +E R + Sbjct: 11 LQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVN 70 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 +RHP +V+L + + E+ DL ++ + Y ++ G Sbjct: 71 SVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT----DVFSEPRAVFYAACVVLG 126 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 + + H ++++RDLK NLL+D +G +K+ADFGL + + T + +PEVL Sbjct: 127 LQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL 186 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 ++ Y+ VD W +G + E+ + F GD E + I Sbjct: 187 TETS-YTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIV------------------ 227 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYFNDL 290 + + +P++ L + ++ ++L +P +R+ + HP+F + Sbjct: 228 NDEVRYPRF-----------LSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLI 276 Query: 291 DNQI 294 D Sbjct: 277 DWSA 280 >6DBN-A nrPDB Length = 316 Score = 199 bits (506), Expect = 1e-51, Method: Composition-based stats. Identities = 78/290 (26%), Positives = 132/290 (45%), Gaps = 27/290 (9%) Query: 4 YTKIEKIGEGTYGVVYKGRHK----TTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR 59 +I +GEG +G V R+ TG+ VA+K ++ ES + +EI +L+ L Sbjct: 37 LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIA-DLKKEIEILRNLY 95 Query: 60 HPNIVSLQDVLMQDSR--LYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 H NIV + + +D + LI EFL S LK+YL ++ Y QI +G+ Sbjct: 96 HENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYL--PKNKNKINLKQQLKYAVQICKGM 153 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT---HEVVTLWYRSPE 173 + SR+ +HRDL +N+L++ + +K+ DFGL +A YT +++ +PE Sbjct: 154 DYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPE 213 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 233 L+ S Y D+WS G EL T + DS+ + + +G + ++ + Sbjct: 214 CLMQSKFY-IASDVWSFGVTLHELLT-----YCDSDSSPMALFLKMIGPTHGQM-----T 262 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 + NT K G N + L+ K + P+ R S + + Sbjct: 263 VTRLVNTL---KEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIE 309 >4OLI-A nrPDB Length = 645 Score = 199 bits (506), Expect = 1e-51, Method: Composition-based stats. Identities = 65/289 (22%), Positives = 117/289 (40%), Gaps = 31/289 (10%) Query: 4 YTKIEKIGEGTYGVV----YKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR 59 KI +GEG +G V Y + TG++VA+K ++ + + S +EI +L+ L Sbjct: 355 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQ-HRSGWKQEIDILRTLY 413 Query: 60 HPNIVSLQDVLMQDSR--LYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 H +I+ + L L+ E++ L+ YL P + + + + QI +G+ Sbjct: 414 HEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL----PRHSIGLAQLLLFAQQICEGM 469 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT---HEVVTLWYRSPE 173 + HS+ +HR+L +N+L+D+ +K+ DFGLA+A Y +++ +PE Sbjct: 470 AYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPE 529 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGT-PNNEVWPEVE 232 L Y D+WS G EL T H DS + +G + Sbjct: 530 CLKEYKFY-YASDVWSFGVTLYELLT-----HCDSSQSPPTKFLELIGIAQGQMTVLRLT 583 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 L + P+ L+ + + R + + Sbjct: 584 ELLERGERLPRPDKCPC---------EVYHLMKNCWETEASFRPTFENL 623 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 56/316 (17%), Positives = 113/316 (35%), Gaps = 72/316 (22%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTG------------------------QVVAMKKIRL 37 ++ T++ +G+GT VY+GR + G V +K + Sbjct: 45 KEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVL-- 102 Query: 38 ESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPP 96 + + SL+ ++ H ++ + V ++ ++ E++ L +L Sbjct: 103 DPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERG 162 Query: 97 GQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGT-------IKLADFGL 149 M +V Q+ + + ++ ++H ++ +N+L+ G IKL+D G+ Sbjct: 163 HVPMAWKMV--VAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGV 220 Query: 150 ARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR-YSTPVDIWSIGTIFAELAT-KKPLFHGD 207 G+ V + + +PE L G A ST +D W G E+ + Sbjct: 221 ----GLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSR 276 Query: 208 SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKM 267 S ++ E ++ P+ LA+ L S+ Sbjct: 277 SPSEK-------------------EHFYQRQHRLPEPSCPQLAT-----------LTSQC 306 Query: 268 LIYDPAKRISGKMALN 283 L Y+P +R S + L Sbjct: 307 LTYEPTQRPSFRTILR 322 >6GQK-A nrPDB Length = 328 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 62/318 (19%), Positives = 120/318 (37%), Gaps = 57/318 (17%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQ-----VVAMKKIRLESEEEGVPSTAIREISLLK 56 + + +G G +G V + + + VA+K ++ S + E+ +L Sbjct: 41 NRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLK-PSAHSTEREALMSELKVLS 99 Query: 57 EL-RHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPP-------------GQYMD 101 L H NIV+L +I E+ DL +L ++ Sbjct: 100 YLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLT 159 Query: 102 SSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV-- 159 + S+ YQ+ +G+ F S+ +HRDL +N+L+ K+ DFGLAR Sbjct: 160 LEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYVD 219 Query: 160 YTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFR 218 + + + + +PE + S Y+ D+WS G EL + + G + +++ + Sbjct: 220 KGNARLPVKWMAPESIFNSV-YTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIK 278 Query: 219 ALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG 278 + ++ + P++ P D++ DP KR + Sbjct: 279 ----------------EGFRMSSPEYAPA-----------EMYDIMKTCWDADPDKRPTF 311 Query: 279 KMALNHPYFNDLDNQIKK 296 K + D++ QI + Sbjct: 312 KQIVQ-----DIEKQISE 324 >5VO2-A nrPDB Length = 300 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 66/284 (23%), Positives = 118/284 (41%), Gaps = 42/284 (14%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 E+ ++ +G G G V+ GR G+ VA+KK+R E + I L++L+H Sbjct: 11 FEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD---------IKHLRKLKH 59 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNI++ + V Q ++ EF + + + + G+ + SL+ + I G+ + H Sbjct: 60 PNIITFKGVCTQAPCYCILMEFCAQG--QLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLH 117 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 +++HRDLK N+LI +K++DFG ++ + T+ + +PEV+ Sbjct: 118 LHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMS-FAGTVAWMAPEVIRNE-P 175 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 S VDIWS G + EL T + + I +G+ + + Sbjct: 176 VSEKVDIWSFGVVLWELLTGEIPYKDVDS----SAIIWGVGSNSLHL------------- 218 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNH 284 + + LL + P R S + L H Sbjct: 219 ----------PVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLH 252 >1TKI-A nrPDB Length = 321 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 67/297 (22%), Positives = 128/297 (43%), Gaps = 33/297 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E Y E +G G +G+V++ ++ + K ++++ ++ + +EIS+L RH Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVK---KEISILNIARHR 61 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NI+ L + L +IFEF+S L + ++ + SY++Q+ + + F HS Sbjct: 62 NILHLHESFESMEELVMIFEFISG-LDIFERINTSAFELNEREIVSYVHQVCEALQFLHS 120 Query: 122 RRVLHRDLKPQNLLIDDK--GTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179 + H D++P+N++ + TIK+ +FG AR P + Y +PEV Sbjct: 121 HNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLK-PGDNFRLLFTAPEYYAPEVHQHDV 179 Query: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239 ST D+WS+GT+ L + F ++ + I A T + E Sbjct: 180 -VSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEE------------- 225 Query: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKK 296 K + +D + ++L+ + R++ AL HP+ ++ Sbjct: 226 ------------AFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQKIERVST 270 >3QGY-A nrPDB Length = 286 Score = 197 bits (502), Expect = 4e-51, Method: Composition-based stats. Identities = 64/263 (24%), Positives = 117/263 (44%), Gaps = 13/263 (4%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 + T +++IG G +G+V+ G + VA+K I+ S E I E ++ +L HP Sbjct: 28 ELTFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIKEGSMSED---DFIEEAEVMMKLSHPK 83 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +V L V ++ + + L+FEF+ L YL + + + + +G+ + Sbjct: 84 LVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQ--RGLFAAETLLGMCLDVCEGMAYLEE 141 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLAR-AFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 V+HRDL +N L+ + IK++DFG+ R T + + SPEV +R Sbjct: 142 ACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV-FSFSR 200 Query: 181 YSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRA--LGTPNNEVWPEVESLQDY 237 YS+ D+WS G + E+ + K + S + + I L P + + Sbjct: 201 YSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHC 260 Query: 238 KNTFPKWKPGSLASHVKNLDENG 260 P+ +P + + ++ L E Sbjct: 261 WKERPEDRP-AFSRLLRQLAEIA 282 >4PWN-A nrPDB Length = 274 Score = 197 bits (501), Expect = 5e-51, Method: Composition-based stats. Identities = 72/289 (24%), Positives = 120/289 (41%), Gaps = 40/289 (13%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 +IG G++ VYKG T VA +++ + E +LK L+HPNIV D Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYD 76 Query: 69 VLMQ----DSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 + L+ E + S LK YL + M +++S+ QIL+G+ F H+R Sbjct: 77 SWESTVKGKKCIVLVTELMTSGTLKTYLKRF---KVMKIKVLRSWCRQILKGLQFLHTRT 133 Query: 124 --VLHRDLKPQNLLIDD-KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 ++HRDLK N+ I G++K+ D GLA + T + +PE+ + Sbjct: 134 PPIIHRDLKCDNIFITGPTGSVKIGDLGLAT-LEKRASFAKSVIGTPEFMAPEMY--EEK 190 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 Y VD+++ G E+AT + + Q++R + P Sbjct: 191 YDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKP----------------- 233 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 AS K +++ + + +R S K LNH +F + Sbjct: 234 ---------ASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >2Y6O-A nrPDB Length = 291 Score = 197 bits (501), Expect = 5e-51, Method: Composition-based stats. Identities = 55/254 (21%), Positives = 108/254 (42%), Gaps = 16/254 (6%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQV---VAMKKIRLESEEEGVPSTAIREISLLKELRH 60 + IG G +G V GR K G+ VA+K ++ ++ + E S++ + H Sbjct: 16 IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQ-RRDFLSEASIMGQFDH 74 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 PNI+ L+ V+ + + +I E++ G+ + L I G+ + Sbjct: 75 PNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGR-FTVIQLVGMLRGIGSGMKYLS 133 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEVV--TLWYRSPEVLLG 177 +HRDL +N+L++ K++DFG++R P YT + + +PE + Sbjct: 134 DMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAI-A 192 Query: 178 SARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWP------E 230 ++++ D+WS G + E+ + + + S D + I P P Sbjct: 193 YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLM 252 Query: 231 VESLQDYKNTFPKW 244 ++ Q ++ PK+ Sbjct: 253 LDCWQKERSDRPKF 266 >6BSD-A nrPDB Length = 876 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 61/324 (18%), Positives = 125/324 (38%), Gaps = 62/324 (19%) Query: 3 DYTKIEKIGEGTYGVVYKG----------------RHKTTGQVVAMKKIRLESEEEGVPS 46 EK+GEG +G V+ K +VA+K +R ++ + + Sbjct: 572 RLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK-NARN 630 Query: 47 TAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIP---------- 95 ++E+ ++ L+ PNI+ L V +QD L +I +++ + DL ++L + Sbjct: 631 DFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAP 690 Query: 96 ------PGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGL 149 G + ++ QI G+ + + +HRDL +N L+ + TIK+ADFG+ Sbjct: 691 GDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGM 750 Query: 150 ARAF--GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAE--LATKKPLFH 205 +R G RV V+ + + + E +L +++T D+W+ G E + + F Sbjct: 751 SRNLYAGDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCRAQPF- 808 Query: 206 GDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLS 265 + + +++ F S + +L+ Sbjct: 809 --------------------GQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELML 848 Query: 266 KMLIYDPAKRISGKMALNHPYFND 289 + + +R H + + Sbjct: 849 RCWSRESEQRPPFSQL--HRFLAE 870 >5KMM-A nrPDB Length = 329 Score = 197 bits (500), Expect = 7e-51, Method: Composition-based stats. Identities = 60/301 (19%), Positives = 111/301 (36%), Gaps = 54/301 (17%) Query: 9 KIGEGTYGVVYKGRHKT-----TGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 ++GEG +G V+ +VA+K ++ E RE LL L+H +I Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK--EASESARQDFQREAELLTMLQHQHI 99 Query: 64 VSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYM------------DSSLVKSYLY 110 V V + L ++FE++ DL ++L S P + + + Sbjct: 100 VRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVAS 159 Query: 111 QILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI--RVYTHEVVTLW 168 Q+ G+V+ +HRDL +N L+ +K+ DFG++R RV ++ + Sbjct: 160 QVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR 219 Query: 169 YRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEV 227 + PE +L +++T D+WS G + E+ T K ++ S + + I + Sbjct: 220 WMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRE------ 272 Query: 228 WPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 + ++ +P +R S K H Sbjct: 273 ----------------------LERPRACPPEVYAIMRGCWQREPQQRHSIKDV--HARL 308 Query: 288 N 288 Sbjct: 309 Q 309 >6DBM-A nrPDB Length = 318 Score = 197 bits (500), Expect = 7e-51, Method: Composition-based stats. Identities = 66/289 (22%), Positives = 118/289 (40%), Gaps = 31/289 (10%) Query: 4 YTKIEKIGEGTYGVV----YKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR 59 KI +GEG +G V Y + TG++VA+K ++ ++ + S +EI +L+ L Sbjct: 33 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQ-HRSGWKQEIDILRTLY 91 Query: 60 HPNIVSLQDVLMQDS--RLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 H +I+ + L L+ E++ L+ YL P + + + + QI +G+ Sbjct: 92 HEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYL----PRHSIGLAQLLLFAQQICEGM 147 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT---HEVVTLWYRSPE 173 + HS+ +HRDL +N+L+D+ +K+ DFGLA+A Y +++ +PE Sbjct: 148 AYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPE 207 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGT-PNNEVWPEVE 232 L Y D+WS G EL T H DS + +G + Sbjct: 208 CLKEYKFY-YASDVWSFGVTLYELLT-----HCDSSQSPPTKFLELIGIAQGQMTVLRLT 261 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 L + P+ L+ + + R + + Sbjct: 262 ELLERGERLPRPDK---------CPAEVYHLMKNCWETEASFRPTFENL 301 >2VWV-A nrPDB Length = 302 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 60/258 (23%), Positives = 111/258 (43%), Gaps = 19/258 (7%) Query: 4 YTKIEK-IGEGTYGVVYKGRHKTTGQV---VAMKKIRLESEEEGVPSTAIREISLLKELR 59 Y KIE+ IG G +G V +GR K G+ VA+K ++ E + E S++ + Sbjct: 17 YVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLK-GGYTERQRREFLSEASIMGQFE 75 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HPNI+ L+ V+ + ++ EF+ + GQ + L I G+ + Sbjct: 76 HPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQ-FTVIQLVGMLRGIASGMRYL 134 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV-----VTLWYRSPEV 174 +HRDL +N+L++ K++DFGL+R T + + + +PE Sbjct: 135 AEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEA 194 Query: 175 LLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWP---- 229 + ++++ D WS G + E+ + + + S D + I + P P Sbjct: 195 I-AFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLH 253 Query: 230 --EVESLQDYKNTFPKWK 245 ++ Q +N P++ Sbjct: 254 QLMLDCWQKDRNARPRFP 271 >4XCU-A nrPDB Length = 300 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 61/264 (23%), Positives = 126/264 (47%), Gaps = 22/264 (8%) Query: 2 EDYTKIEKIGEGTYGVVYKGR-------HKTTGQVVAMKKIRLESEEEGVPSTAIREISL 54 + + +GEG +G V + VA+K ++ ++ + + + E+ + Sbjct: 17 DRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLK-DNASDKDLADLVSEMEV 75 Query: 55 LKEL-RHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPP----GQYMDSSLVKSY 108 +K + RH NI++L V Q+ LY+I E + +L+++L + P + ++ S Sbjct: 76 MKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSC 135 Query: 109 LYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG--IPIRVYTHEVVT 166 YQ+ +G+ + SR+ +HRDL +N+L+ + +K+ADFGLAR + ++ + Sbjct: 136 AYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLP 195 Query: 167 LWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFR---ALGT 222 + + +PE L Y+ D+WS G + E+ T + G +++LF + R + Sbjct: 196 VKWMAPEALFDRV-YTHQSDVWSFGILLWEIFTLGGSPYPGI-PVEELFSLLREGHRMDR 253 Query: 223 PNNEVWPEVESLQDYKNTFPKWKP 246 P + +++ + P +P Sbjct: 254 PPHCPPELYGLMRECWHAAPSQRP 277 >6FEX-A nrPDB Length = 321 Score = 195 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 61/318 (19%), Positives = 125/318 (39%), Gaps = 56/318 (17%) Query: 3 DYTKIEKIGEGTYGVVYKG----------------RHKTTGQVVAMKKIRLESEEEGVPS 46 EK+GEG +G V+ K +VA+K +R ++ + + Sbjct: 17 RLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK-NARN 75 Query: 47 TAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYL----------DSIP 95 ++E+ ++ L+ PNI+ L V +QD L +I +++ + DL ++L + P Sbjct: 76 DFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAP 135 Query: 96 PGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-- 153 + ++ QI G+ + + +HRDL +N L+ + TIK+ADFG++R Sbjct: 136 GDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYA 195 Query: 154 GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAE--LATKKPLFHGDSEID 211 G RV V+ + + + E +L +++T D+W+ G E + + F Sbjct: 196 GDYYRVQGRAVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCRAQPF------- 247 Query: 212 QLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYD 271 + + +++ F S + +L+ + + Sbjct: 248 --------------GQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRE 293 Query: 272 PAKRISGKMALNHPYFND 289 +R H + + Sbjct: 294 SEQRPPFSQL--HRFLAE 309 >4Y93-A nrPDB Length = 446 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 66/268 (24%), Positives = 122/268 (45%), Gaps = 15/268 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQV-VAMKKIRLESEEEGVPSTAIREISLLKELRH 60 +D T ++++G G +GVV G+ + GQ VA+K I+ S E I E ++ L H Sbjct: 188 KDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSED---EFIEEAKVMMNLSH 242 Query: 61 PNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 +V L V + +++I E++ + L YL + + + + + + + Sbjct: 243 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM--RHRFQTQQLLEMCKDVCEAMEYL 300 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARA-FGIPIRVYTHEVVTLWYRSPEVLLGS 178 S++ LHRDL +N L++D+G +K++DFG+ R T + + SPEVL+ Sbjct: 301 ESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLM-Y 359 Query: 179 ARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 +++S+ DIW+ G + E+ + K + + + I + L P + E Y Sbjct: 360 SKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYAIMY 419 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLS 265 + K L N LD++ Sbjct: 420 S---CWHEKADERPTFKILLSNILDVMD 444 >4KIK-B nrPDB Length = 677 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 76/284 (26%), Positives = 132/284 (46%), Gaps = 18/284 (6%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 + E++G G +G V + ++ TG+ +A+K+ R E + EI +++ L HPN+ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL-EIQIMRRLTHPNV 79 Query: 64 VSLQDV------LMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 V+ +DV L + L E+ DL+KYL+ + + + L I + Sbjct: 80 VAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASAL 139 Query: 117 VFCHSRRVLHRDLKPQNLLI---DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 173 + H R++HRDLKP+N+++ + + K+ D G A+ + T V TL Y +PE Sbjct: 140 RYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGS-LCTSFVGTLQYLAPE 198 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 233 LL +Y+ VD WS GT+ E T F + + Q R + V ++ Sbjct: 199 -LLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNG 257 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS 277 + ++ P P +L S + E L L ML++ P +R + Sbjct: 258 TVKFSSSLPY--PNNLNSVLAERLEKWLQL---MLMWHPRQRGT 296 >1ZXE-A nrPDB Length = 303 Score = 194 bits (494), Expect = 3e-50, Method: Composition-based stats. Identities = 77/324 (23%), Positives = 134/324 (41%), Gaps = 62/324 (19%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D+ +I +G+G +G V K R+ + A+KKIR E+ ST + E+ LL L H Sbjct: 7 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEK---LSTILSEVMLLASLNHQY 63 Query: 63 IVSLQDVLMQ-------------DSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSY 108 +V ++ S L++ E+ L + S Q D Sbjct: 64 VVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYW--RL 121 Query: 109 LYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV--------- 159 QIL+ + + HS+ ++HR+LKP N+ ID+ +K+ DFGLA+ + + Sbjct: 122 FRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLP 181 Query: 160 -----YTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLF 214 T + T Y + EVL G+ Y+ +D++S+G IF E+ P G ++ L Sbjct: 182 GSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI--YPFSTGMERVNILK 239 Query: 215 RIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAK 274 ++ +E D+ + K + ++ ++ +DP K Sbjct: 240 KLRSV----------SIEFPPDFDDNKMKVEKK---------------IIRLLIDHDPNK 274 Query: 275 RISGKMALNHPYF--NDLDNQIKK 296 R + LN + D IK+ Sbjct: 275 RPGARTLLNSGWLPVKHQDEVIKE 298 >3ORP-A nrPDB Length = 311 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 59/243 (24%), Positives = 101/243 (41%), Gaps = 11/243 (4%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE-SEEEGVPSTAIREISLLKELRH 60 + Y E +G G V+ R + VA+K +R + + + RE L H Sbjct: 12 DRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNH 71 Query: 61 PNIVSLQDVLMQDSRL----YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 P IV++ D ++ Y++ E++ D + M + Q + Sbjct: 72 PAIVAVYDTGEAETPAGPLPYIVMEYVDG--VTLRDIVHTEGPMTPKRAIEVIADACQAL 129 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHE---VVTLWYRSPE 173 F H ++HRD+KP N++I +K+ DFG+ARA T + T Y SPE Sbjct: 130 NFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPE 189 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 233 G + D++S+G + E+ T +P F GDS + ++ R P + + + Sbjct: 190 QARGDS-VDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSA 248 Query: 234 LQD 236 D Sbjct: 249 DLD 251 >1K9A-A nrPDB Length = 450 Score = 193 bits (491), Expect = 7e-50, Method: Composition-based stats. Identities = 64/290 (22%), Positives = 119/290 (41%), Gaps = 45/290 (15%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 M++ ++ IG+G +G V G ++ G VA+K I+ + + E S++ +LRH Sbjct: 192 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK----NDATAQAFLAEASVMTQLRH 245 Query: 61 PNIVSLQDVL-MQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 N+V L V+ + LY++ E+++ L YL S + + + + + + + Sbjct: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRS-VLGGDCLLKFSLDVCEAMEY 304 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 +HRDL +N+L+ + K++DFGL + + + + +PE L Sbjct: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK---LPVKWTAPEALR-E 360 Query: 179 ARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 ++ST D+WS G + E+ + + + P +V P VE + Y Sbjct: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYP---------------RIPLKDVVPRVE--KGY 403 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA---LNH 284 K P P D++ D A R + L H Sbjct: 404 KMDAPDGCP-----------PAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 >6FER-A nrPDB Length = 309 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 69/304 (22%), Positives = 124/304 (40%), Gaps = 47/304 (15%) Query: 4 YTKIEKIGEGTYGVVYKG--------RHK--------TTGQVVAMKKIRLESEEEGVPST 47 T EK+GEG +G V+ + K +VA+K +R ++ + + Sbjct: 11 LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK-NARND 69 Query: 48 AIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSL-- 104 ++EI ++ L+ PNI+ L V + D L +I E++ + DL ++L P S + Sbjct: 70 FLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRT 129 Query: 105 -----VKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPI 157 +K QI G+ + S +HRDL +N L+ TIK+ADFG++R G Sbjct: 130 VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYY 189 Query: 158 RVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIF 217 R+ V+ + + S E +L +++T D+W+ G E T F + QL Sbjct: 190 RIQGRAVLPIRWMSWESIL-LGKFTTASDVWAFGVTLWETFT----FCQEQPYSQL---- 240 Query: 218 RALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS 277 + + +++ F + ++ L+ D R S Sbjct: 241 -----------SDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPS 289 Query: 278 GKMA 281 + Sbjct: 290 FQEI 293 >3QA8-A nrPDB Length = 676 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 76/287 (26%), Positives = 131/287 (45%), Gaps = 18/287 (6%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 + E++G G +G V + H+ TG+ VA+K+ R E + + EI ++K+L HPN+ Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCL-EIQIMKKLNHPNV 74 Query: 64 VSLQDV------LMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 VS ++V L + L E+ DL+KYL+ + +++ L I + Sbjct: 75 VSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSAL 134 Query: 117 VFCHSRRVLHRDLKPQNLLID---DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 173 + H R++HRDLKP+N+++ + K+ D G A+ + T V TL Y +PE Sbjct: 135 RYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQ-GELCTEFVGTLQYLAPE 193 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 233 LL +Y+ VD WS GT+ E T F + + Q R + V+ ++ Sbjct: 194 -LLEQKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREKSNEHIVVYDDLTG 252 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKM 280 + + P P L+ + E L ML++ +R + Sbjct: 253 AVKFSSVLP--TPNHLSGILAGKLERW---LQCMLMWHQRQRGTDPQ 294 >3PP0-A nrPDB Length = 338 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 60/270 (22%), Positives = 108/270 (40%), Gaps = 16/270 (5%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQ----VVAMKKIRLESEEEGVPSTAIREISLLKEL 58 + K++ +G G +G VYKG G+ VA+K +R E+ + E ++ + Sbjct: 18 ELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLR-ENTSPKANKEILDEAYVMAGV 76 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQ-YMDSSLVKSYLYQILQGIV 117 P + L + + S + L+ + + LD + + + S + ++ QI +G+ Sbjct: 77 GSPYVSRLLGICLT-STVQLVTQLMPYG--CLLDHVRENRGRLGSQDLLNWCMQIAKGMS 133 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV--TLWYRSPEVL 175 + R++HRDL +N+L+ +K+ DFGLAR I Y + + + + E + Sbjct: 134 YLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESI 193 Query: 176 LGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDS--EIDQLFRIFRALGTPNNEVWPEVE 232 L R++ D+WS G EL T + G EI L L P Sbjct: 194 L-RRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYM 252 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLD 262 + + +P V D Sbjct: 253 IMVKCWMIDSECRPR-FRELVSEFSRMARD 281 >2HK5-A nrPDB Length = 270 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 61/250 (24%), Positives = 110/250 (44%), Gaps = 12/250 (4%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E +K+G G +G V+ + + VA+K ++ S + E +++K L+H Sbjct: 15 ESLKLEKKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSMS---VEAFLAEANVMKTLQHD 70 Query: 62 NIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 +V L V+ ++ +Y+I EF++ L +L S G + + QI +G+ F Sbjct: 71 KLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKS-DEGSKQPLPKLIDFSAQIAEGMAFIE 128 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGI-PIRVYTHEVVTLWYRSPEVLLGSA 179 R +HRDL+ N+L+ K+ADFGLAR + + +PE + Sbjct: 129 QRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAI-NFG 187 Query: 180 RYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPE--VESLQD 236 ++ D+WS G + E+ T + + G S + + + R P E PE + Sbjct: 188 SFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMR 247 Query: 237 YKNTFPKWKP 246 P+ +P Sbjct: 248 CWKNRPEERP 257 >5TUR-A nrPDB Length = 404 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 112/295 (37%), Gaps = 45/295 (15%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVP----STAIREISLLKEL 58 Y +G G +G VY G + VA+K + + + + E+ LLK++ Sbjct: 128 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 187 Query: 59 RH--PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 ++ L D + LI E ++ D I + L +S+ +Q+L+ + Sbjct: 188 SSGFSGVIRLLDWFERPDSFVLILE-RPEPVQDLFDFITERGALQEELARSFFWQVLEAV 246 Query: 117 VFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 CH+ VLHRD+K +N+LID ++G +KL DFG VYT T Y PE + Sbjct: 247 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD--TVYTDFDGTRVYSPPEWI 304 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 + +WS+G + ++ F D EI + FR Sbjct: 305 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ---------------- 348 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 + L+ L P+ R + + NHP+ D+ Sbjct: 349 -------------------RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 384 >4XI2-A nrPDB Length = 446 Score = 191 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 60/252 (23%), Positives = 115/252 (45%), Gaps = 14/252 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQV-VAMKKIRLESEEEGVPSTAIREISLLKELRH 60 +D T ++++G G +GVV G+ + GQ VA+K IR S E I E ++ L H Sbjct: 187 KDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIREGSMSED---EFIEEAKVMMNLSH 241 Query: 61 PNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 +V L V + +++I E++ + L YL + + + + + + + Sbjct: 242 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM--RHRFQTQQLLEMCKDVCEAMEYL 299 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARA-FGIPIRVYTHEVVTLWYRSPEVLLGS 178 S++ LHRDL +N L++D+G +K++DFGL+R + + PEVL+ Sbjct: 300 ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLM-Y 358 Query: 179 ARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALG--TPNNEVWPEVESLQ 235 +++S+ DIW+ G + E+ + K + + + I + L P+ + Sbjct: 359 SKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMY 418 Query: 236 DYKNTFPKWKPG 247 + +P Sbjct: 419 SCWHEKADERPS 430 >2OGV-A nrPDB Length = 317 Score = 191 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 54/297 (18%), Positives = 115/297 (38%), Gaps = 46/297 (15%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQV-----VAMKKIRLESEEEGVPSTAIREISLLK 56 + + +G G +G V + G+ VA+K ++ + + E+ ++ Sbjct: 38 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-STAHADEKEALMSELKIMS 96 Query: 57 EL-RHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSI-------PPGQYMDSSLVKS 107 L +H NIV+L + +I E+ DL +L G+ ++ + Sbjct: 97 HLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLH 156 Query: 108 YLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--VYTHEVV 165 + Q+ QG+ F S+ +HRD+ +N+L+ + K+ DFGLAR V + + Sbjct: 157 FSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARL 216 Query: 166 TLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPN 224 + + +PE + Y+ D+WS G + E+ + + G + +++ + Sbjct: 217 PVKWMAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK------ 269 Query: 225 NEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 Y+ P + P ++ S ++ +P R + + Sbjct: 270 ----------DGYQMAQPAFAPKNIYS-----------IMQACWALEPTHRPTFQQI 305 >1FVR-A nrPDB Length = 327 Score = 191 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 63/298 (21%), Positives = 119/298 (39%), Gaps = 47/298 (15%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVV--AMKKIRLESEEEGVPSTAIREISLLKELR 59 D + IGEG +G V K R K G + A+K+++ + ++ A L K Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGH 84 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQY-------------MDSSLV 105 HPNI++L LYL E+ +L +L + + S + Sbjct: 85 HPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQL 144 Query: 106 KSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV 165 + + +G+ + ++ +HRDL +N+L+ + K+ADFGL+R + ++ T + Sbjct: 145 LHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVK-KTMGRL 203 Query: 166 TLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPN 224 + + + E L + Y+T D+WS G + E+ + + G + + ++ + Sbjct: 204 PVRWMAIESL-NYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQG----- 257 Query: 225 NEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMAL 282 Y+ P N D+ DL+ + P +R S L Sbjct: 258 ------------YRLEKP-----------LNCDDEVYDLMRQCWREKPYERPSFAQIL 292 >3KRL-A nrPDB Length = 335 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 56/303 (18%), Positives = 116/303 (38%), Gaps = 52/303 (17%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQV-----VAMKKIRLESEEEGVPSTAIREISLLK 56 + + +G G +G V + G+ VA+K ++ + + E+ ++ Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-STAHADEKEALMSELKIMS 104 Query: 57 EL-RHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLD-------------SIPPGQYMD 101 L +H NIV+L + +I E+ DL +L S P + + Sbjct: 105 HLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLS 164 Query: 102 SSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--V 159 S + + Q+ QG+ F S+ +HRD+ +N+L+ + K+ DFGLAR V Sbjct: 165 SRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIV 224 Query: 160 YTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFR 218 + + + + +PE + Y+ D+WS G + E+ + + G + +++ + Sbjct: 225 KGNARLPVKWMAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK 283 Query: 219 ALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG 278 Y+ P + P ++ S ++ +P R + Sbjct: 284 ----------------DGYQMAQPAFAPKNIYS-----------IMQACWALEPTHRPTF 316 Query: 279 KMA 281 + Sbjct: 317 QQI 319 >4PDO-A nrPDB Length = 299 Score = 191 bits (485), Expect = 3e-49, Method: Composition-based stats. Identities = 59/255 (23%), Positives = 114/255 (44%), Gaps = 19/255 (7%) Query: 5 TKIEKIGEGTYGVVYKGRHKTTG----QVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 T+ + IG G +G VYKG KT+ VA+K ++ E+ + E ++ + H Sbjct: 37 TRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRV-DFLGEAGIMGQFSH 95 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 NI+ L+ V+ + + +I E++ L K+L + L I G+ + Sbjct: 96 HNIIRLEGVISKYKPMMIITEYMENGALDKFLRE--KDGEFSVLQLVGMLRGIAAGMKYL 153 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEVV--TLWYRSPEVLL 176 + +HRDL +N+L++ K++DFGL+R P YT + + +PE + Sbjct: 154 ANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAI- 212 Query: 177 GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQL------FRIFRALGTPNNEVWP 229 ++++ D+WS G + E+ T + + S + + FR+ + P+ Sbjct: 213 SYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQL 272 Query: 230 EVESLQDYKNTFPKW 244 ++ Q + PK+ Sbjct: 273 MMQCWQQERARRPKF 287 >3BEA-A nrPDB Length = 333 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 53/301 (17%), Positives = 113/301 (37%), Gaps = 50/301 (16%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQV-----VAMKKIRLESEEEGVPSTAIREISLLK 56 + + +G G +G V + G+ VA+K ++ + + E+ ++ Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-STAHADEKEALMSELKIMS 104 Query: 57 EL-RHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPP-----------GQYMDSS 103 L +H NIV+L + +I E+ DL +L + + Sbjct: 105 HLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTR 164 Query: 104 LVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--VYT 161 + + Q+ QG+ F S+ +HRD+ +N+L+ + K+ DFGLAR V Sbjct: 165 DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKG 224 Query: 162 HEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRAL 220 + + + + +PE + Y+ D+WS G + E+ + + G + +++ + Sbjct: 225 NARLPVKWMAPESIFDCV-YTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK-- 281 Query: 221 GTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKM 280 Y+ P + P ++ S ++ +P R + + Sbjct: 282 --------------DGYQMAQPAFAPKNIYS-----------IMQACWALEPTHRPTFQQ 316 Query: 281 A 281 Sbjct: 317 I 317 >3I81-A nrPDB Length = 315 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 67/296 (22%), Positives = 117/296 (39%), Gaps = 46/296 (15%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQ-----VVAMKKIRLESEEEGVPSTAIREISLLK 56 E T ++G+G++G+VY+G K + VA+K + E+ + E S++K Sbjct: 18 EKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EAASMRERIEFLNEASVMK 76 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLV-------KSY 108 E ++V L V+ Q +I E ++ DLK YL S+ P + L Sbjct: 77 EFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQM 136 Query: 109 LYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV--T 166 +I G+ + ++ + +HRDL +N ++ + T+K+ DFG+ R Sbjct: 137 AGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLP 196 Query: 167 LWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNN 225 + + SPE L ++T D+WS G + E+AT + + G S L + Sbjct: 197 VRWMSPESLKD-GVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVME------- 248 Query: 226 EVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 G L N + +L+ Y+P R S Sbjct: 249 ---------------------GGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 283 >3CJF-A nrPDB Length = 309 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 66/280 (23%), Positives = 119/280 (42%), Gaps = 27/280 (9%) Query: 2 EDYTKIEKIGEGTYGVVYK----GRHKT-TGQVVAMKKIRLESEEEGVPSTAIREISLLK 56 + + +G G +G V + G KT T + VA+K ++ E + E+ +L Sbjct: 27 DRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-EGATHSEHRALMSELKILI 85 Query: 57 ELRHP-NIVSLQDVLMQ-DSRLYLIFEFLS-MDLKKYLDSIPP---------GQYMDSSL 104 + H N+V+L + L +I EF +L YL S ++ Sbjct: 86 HIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEH 145 Query: 105 VKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV--YTH 162 + Y +Q+ +G+ F SR+ +HRDL +N+L+ +K +K+ DFGLAR Sbjct: 146 LICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGD 205 Query: 163 EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHG---DSEIDQLFRIFR 218 + L + +PE + Y+ D+WS G + E+ + + G D E + + Sbjct: 206 ARLPLKWMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGT 264 Query: 219 ALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNL 256 + P+ +++ D + P +P L H+ NL Sbjct: 265 RMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNL 304 >3BBT-B nrPDB Length = 328 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 57/270 (21%), Positives = 110/270 (40%), Gaps = 16/270 (5%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVV----AMKKIRLESEEEGVPSTAIREISLLKEL 58 + +++ +G G +G VYKG G+ V A+K + + + + E ++ + Sbjct: 16 ELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVE-FMDEALIMASM 74 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 HP++V L V + + + L+ + + L +Y+ + S L+ ++ QI +G++ Sbjct: 75 DHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDN--IGSQLLLNWCVQIAKGMM 131 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV--TLWYRSPEVL 175 + RR++HRDL +N+L+ +K+ DFGLAR + Y + + + + E + Sbjct: 132 YLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECI 191 Query: 176 LGSARYSTPVDIWSIGTIFAELAT-KKPLFHG--DSEIDQLFRIFRALGTPNNEVWPEVE 232 +++ D+WS G EL T + G EI L L P Sbjct: 192 -HYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYM 250 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLD 262 + +P D Sbjct: 251 VMVKCWMIDADSRPK-FKELAAEFSRMARD 279 >3OMV-A nrPDB Length = 307 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 66/282 (23%), Positives = 120/282 (42%), Gaps = 30/282 (10%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 +IG G++G VYKG+ VA+K +++ E+++L++ RH NI+ Sbjct: 43 RIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMG 99 Query: 69 VLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHR 127 M L ++ ++ L K+L M + Q QG+ + H++ ++HR Sbjct: 100 -YMTKDNLAIVTQWCEGSSLYKHLHVQETKFQM--FQLIDIARQTAQGMDYLHAKNIIHR 156 Query: 128 DLKPQNLLIDDKGTIKLADFGLARAFG--IPIRVYTHEVVTLWYRSPEVL--LGSARYST 183 D+K N+ + + T+K+ DFGLA + ++ + +PEV+ + +S Sbjct: 157 DMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSF 216 Query: 184 PVDIWSIGTIFAELATKKPLFHGDSEIDQ-LFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 D++S G + EL T + + + DQ +F + R +P+ L P Sbjct: 217 QSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPD---------LSKLYKNCP 267 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNH 284 K +A VK + E L ++L S L H Sbjct: 268 KAMKRLVADCVKKVKEE-RPLFPQIL--------SSIELLQH 300 >3SXS-A nrPDB Length = 268 Score = 190 bits (484), Expect = 5e-49, Method: Composition-based stats. Identities = 63/251 (25%), Positives = 121/251 (48%), Gaps = 14/251 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQV-VAMKKIRLESEEEGVPSTAIREISLLKELRH 60 E+ T ++++G G +GVV G+ K GQ VA+K I+ S E +E + +L H Sbjct: 8 EEITLLKELGSGQFGVVKLGKWK--GQYDVAVKMIKEGSMSED---EFFQEAQTMMKLSH 62 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 P +V V ++ +Y++ E++S L YL S G ++ S + Y + +G+ F Sbjct: 63 PKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKG--LEPSQLLEMCYDVCEGMAFL 120 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT-HEVVTLWYRSPEVLLGS 178 S + +HRDL +N L+D +K++DFG+ R V + + + +PEV Sbjct: 121 ESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEV-FHY 179 Query: 179 ARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRA--LGTPNNEVWPEVESLQ 235 +YS+ D+W+ G + E+ + K + + + + ++ + L P+ + + Sbjct: 180 FKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIMY 239 Query: 236 DYKNTFPKWKP 246 + P+ +P Sbjct: 240 SCWHELPEKRP 250 >1BYG-A nrPDB Length = 278 Score = 190 bits (484), Expect = 5e-49, Method: Composition-based stats. Identities = 55/255 (21%), Positives = 115/255 (45%), Gaps = 16/255 (6%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 M++ ++ IG+G +G V G ++ G VA+K I+ + + E S++ +LRH Sbjct: 20 MKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIK----NDATAQAFLAEASVMTQLRH 73 Query: 61 PNIVSLQDVL-MQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 N+V L V+ + LY++ E+++ L YL S + + + + + + + Sbjct: 74 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRS-RGRSVLGGDCLLKFSLDVCEAMEY 132 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 +HRDL +N+L+ + K++DFGL + + + + +PE L Sbjct: 133 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGK---LPVKWTAPEALR-E 188 Query: 179 ARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRA--LGTPNNEVWPEVESLQ 235 ++ST D+WS G + E+ + + + D + R+ + + P+ E ++ Sbjct: 189 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK 248 Query: 236 DYKNTFPKWKPGSLA 250 + + +P L Sbjct: 249 NCWHLDAAMRPSFLQ 263 >3KUL-B nrPDB Length = 325 Score = 190 bits (483), Expect = 6e-49, Method: Composition-based stats. Identities = 55/254 (21%), Positives = 101/254 (39%), Gaps = 12/254 (4%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQV---VAMKKIRLESEEEGVPSTAIREISLLKELR 59 + IG G G V GR + GQ VA+K ++ E + E S++ + Sbjct: 50 RIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALK-AGYTERQRRDFLSEASIMGQFD 108 Query: 60 HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 HPNI+ L+ V+ + ++ E++ GQ + L + G+ + Sbjct: 109 HPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQ-FTIMQLVGMLRGVGAGMRYL 167 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR---VYTHEVVTLWYRSPEVLL 176 +HRDL +N+L+D K++DFGL+R T + + + +PE + Sbjct: 168 SDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAI- 226 Query: 177 GSARYSTPVDIWSIGTIFAE-LATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV--ES 233 +S+ D+WS G + E LA + + + D + + P P + Sbjct: 227 AFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQL 286 Query: 234 LQDYKNTFPKWKPG 247 + D + +P Sbjct: 287 MLDCWHKDRAQRPR 300 >4E20-A nrPDB Length = 290 Score = 190 bits (483), Expect = 6e-49, Method: Composition-based stats. Identities = 66/285 (23%), Positives = 116/285 (40%), Gaps = 31/285 (10%) Query: 4 YTKIEKIGEGTYGVV----YKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR 59 KI +GEG +G V Y + TG++VA+K ++ E + S REI +L+ L Sbjct: 10 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALK-EGCGPQLRSGWQREIEILRTLY 68 Query: 60 HPNIVSLQDVLMQDSR--LYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 H +IV + + L+ E++ L+ YL P + + + + QI +G+ Sbjct: 69 HEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYL----PRHCVGLAQLLLFAQQICEGM 124 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT---HEVVTLWYRSPE 173 + H++ +HR L +N+L+D+ +K+ DFGLA+A Y +++ +PE Sbjct: 125 AYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPE 184 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG-TPNNEVWPEVE 232 L Y D+WS G EL T + DS + +G T + Sbjct: 185 CLKECKFY-YASDVWSFGVTLYELLT-----YCDSNQSPHTKFTELIGHTQGQMTVLRLT 238 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS 277 L + P+ L+ + + R + Sbjct: 239 ELLERGERLPRPDRCPC---------EIYHLMKNCWETEASFRPT 274 >3BGP-A nrPDB Length = 333 Score = 190 bits (483), Expect = 7e-49, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 112/295 (37%), Gaps = 45/295 (15%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVP----STAIREISLLKEL 58 Y +G G +G VY G + VA+K + + + + E+ LLK++ Sbjct: 57 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 116 Query: 59 RH--PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 ++ L D + LI E ++ D I + L +S+ +Q+L+ + Sbjct: 117 SSGFSGVIRLLDWFERPDSFVLILE-RPEPVQDLFDFITERGALQEELARSFFWQVLEAV 175 Query: 117 VFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 CH+ VLHRD+K +N+LID ++G +KL DFG VYT T Y PE + Sbjct: 176 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD--TVYTDFDGTRVYSPPEWI 233 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 + +WS+G + ++ F D EI + FR Sbjct: 234 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ---------------- 277 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 + L+ L P+ R + + NHP+ D+ Sbjct: 278 -------------------RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 313 >6E4F-A nrPDB Length = 290 Score = 190 bits (482), Expect = 9e-49, Method: Composition-based stats. Identities = 59/251 (23%), Positives = 115/251 (45%), Gaps = 14/251 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQV-VAMKKIRLESEEEGVPSTAIREISLLKELRH 60 +D T ++++G G +GVV G+ + GQ VA+K I+ S E I E ++ L H Sbjct: 31 KDLTFLKELGTGQFGVVKYGKWR--GQYDVAIKMIKEGSMSED---EFIEEAKVMMNLSH 85 Query: 61 PNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 +V L V + +++I E++ + L YL + + + + + + + Sbjct: 86 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM--RHRFQTQQLLEMCKDVCEAMEYL 143 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARA-FGIPIRVYTHEVVTLWYRSPEVLLGS 178 S++ LHRDL +N L++D+G +K++DFGL+R + + PEVL+ Sbjct: 144 ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLM-Y 202 Query: 179 ARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALG--TPNNEVWPEVESLQ 235 +++S+ DIW+ G + E+ + K + + + I + L P+ + Sbjct: 203 SKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMY 262 Query: 236 DYKNTFPKWKP 246 + +P Sbjct: 263 SCWHEKADERP 273 >3LZB-A nrPDB Length = 327 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 62/270 (22%), Positives = 114/270 (42%), Gaps = 16/270 (5%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVV----AMKKIRLESEEEGVPSTAIREISLLKEL 58 ++ KI+ +G G +G VYKG G+ V A+K++R E+ + E ++ + Sbjct: 16 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASV 74 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 +P++ L + + S + LI + + L Y+ + S + ++ QI +G+ Sbjct: 75 DNPHVCRLLGICLT-STVQLITQLMPFGCLLDYVREHKDN--IGSQYLLNWCVQIAKGMN 131 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV--TLWYRSPEVL 175 + RR++HRDL +N+L+ +K+ DFGLA+ G + Y E + + + E + Sbjct: 132 YLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESI 191 Query: 176 LGSARYSTPVDIWSIGTIFAELAT-KKPLFHG--DSEIDQLFRIFRALGTPNNEVWPEVE 232 L Y+ D+WS G EL T + G SEI + L P Sbjct: 192 LHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYM 250 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLD 262 ++ +P + + D Sbjct: 251 IMRKCWMIDADSRPK-FRELIIEFSKMARD 279 >5TQX-A nrPDB Length = 655 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 81/278 (29%), Positives = 123/278 (44%), Gaps = 19/278 (6%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 E++G G +G V +H+ +A+K RLE + EI ++K+L H N+V Sbjct: 14 ERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKN-RERWCHEIQIMKKLNHANVVKAC 72 Query: 68 DV------LMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 DV L+ D L L E+ DL+K L+ + S + S L I GI + H Sbjct: 73 DVPEELNILIHDVPL-LAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLH 131 Query: 121 SRRVLHRDLKPQNLLIDDKG---TIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 +++HRDLKP+N+++ D G K+ D G A+ + T V TL Y +PE L Sbjct: 132 ENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQ-GELCTEFVGTLQYLAPE-LFE 189 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 + Y+ VD WS GT+ E F + + E+ + Sbjct: 190 NKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRF 249 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKR 275 + P+ P SL S + EN L L ML +DP +R Sbjct: 250 SSHLPQ--PNSLCSLIVEPMENWLQL---MLNWDPQQR 282 >5GNK-A nrPDB Length = 297 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 62/270 (22%), Positives = 113/270 (41%), Gaps = 16/270 (5%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVV----AMKKIRLESEEEGVPSTAIREISLLKEL 58 ++ KI+ +G G +G VYKG G+ V A+K++R E+ + E ++ + Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASV 78 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 +P++ L + + S + LI + + L Y+ + S + ++ QI +G+ Sbjct: 79 DNPHVCRLLGICLT-STVQLIMQLMPFGCLLDYVREHKDN--IGSQYLLNWCVQIAKGMN 135 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV--TLWYRSPEVL 175 + RR++HRDL +N+L+ +K+ DFGLA+ G + Y E + + + E + Sbjct: 136 YLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESI 195 Query: 176 LGSARYSTPVDIWSIGTIFAELAT-KKPLFHG--DSEIDQLFRIFRALGTPNNEVWPEVE 232 L Y+ D+WS G EL T + G SEI + L P Sbjct: 196 LHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYM 254 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLD 262 + +P + + D Sbjct: 255 IMVKCWMIDADSRPK-FRELIIEFSKMARD 283 >3DLS-A nrPDB Length = 335 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 62/294 (21%), Positives = 113/294 (38%), Gaps = 43/294 (14%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES------EEEGVPSTAIREISLL 55 + Y+ + +G G +G V+ K + V +K I+ E E+ EI++L Sbjct: 24 QKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAIL 83 Query: 56 KELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 + H NI+ + D+ L+ E L I +D L Q++ Sbjct: 84 SRVEHANIIKVLDIFENQGFFQLVMEKHGSGL-DLFAFIDRHPRLDEPLASYIFRQLVSA 142 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 + + + ++HRD+K +N++I + TIKL DFG A YT T+ Y +PEVL Sbjct: 143 VGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYT-FCGTIEYCAPEVL 201 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 +G+ +++WS+G L ++ F +L A P Sbjct: 202 MGNPYRGPELEMWSLGVTLYTLVFEENPFC------ELEETVEAAIHPPY---------- 245 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289 + + + L+S +L P +R + + + P+ Sbjct: 246 -------------------LVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQ 280 >4LFI-A nrPDB Length = 374 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 81/341 (23%), Positives = 152/341 (44%), Gaps = 52/341 (15%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAM------------------------KKIRL 37 +DY K+G G Y V++G + + + K Sbjct: 40 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 99 Query: 38 ESEEEGVPSTAIREISLLKELR----------HPNIVSLQDVLMQD--SRLYLIFEFLSM 85 + ++ +LK +R H NI+ L D++ L+FE++ Sbjct: 100 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV-- 157 Query: 86 DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDD-KGTIKL 144 +D + ++ Y++++L+ + +CHS ++HRD+KP N++ID ++L Sbjct: 158 ---DNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRL 214 Query: 145 ADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFA-ELATKKPL 203 D+GLA + + + Y V + +++ PE+L+ Y +D+WS GT+ A + ++P Sbjct: 215 IDWGLAEFYHVNME-YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 273 Query: 204 FHGDSEIDQLFRIFRALGTPNNE--------VWPEVESLQDYKNTFPKWKPGSLASHVKN 255 FHG S DQL +I + LGT + E P D P + + + + Sbjct: 274 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 333 Query: 256 LDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKK 296 ++ +DL+ +L YD +R++ K A+ HP+F + QI+K Sbjct: 334 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 374 >4RC3-A nrPDB Length = 289 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 112/295 (37%), Gaps = 45/295 (15%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVP----STAIREISLLKEL 58 Y +G G +G VY G + VA+K + + + + E+ LLK++ Sbjct: 13 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 72 Query: 59 RH--PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 ++ L D + LI E ++ D I + L +S+ +Q+L+ + Sbjct: 73 SSGFSGVIRLLDWFERPDSFVLILE-RPEPVQDLFDFITERGALQEELARSFFWQVLEAV 131 Query: 117 VFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVL 175 CH+ VLHRD+K +N+LID ++G +KL DFG VYT T Y PE + Sbjct: 132 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD--TVYTDFDGTRVYSPPEWI 189 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 + +WS+G + ++ F D EI + FR Sbjct: 190 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ---------------- 233 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 + L+ L P+ R + + NHP+ D+ Sbjct: 234 -------------------RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 269 >4M7I-A nrPDB Length = 299 Score = 188 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 76/291 (26%), Positives = 127/291 (43%), Gaps = 34/291 (11%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 + D+ I+ +G G +GVV++ ++K A+K+IRL E +RE+ L +L H Sbjct: 4 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRL-PNRELAREKVMREVKALAKLEH 62 Query: 61 PNIVSLQDVLMQDS------------RLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKS 107 P IV + ++ + LY+ + +LK +++ + + S+ Sbjct: 63 PGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLH 122 Query: 108 YLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV-------- 159 QI + + F HS+ ++HRDLKP N+ +K+ DFGL A Sbjct: 123 IFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMP 182 Query: 160 ----YTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFR 215 +T +V T Y SPE + G++ YS VDI+S+G I EL F E + Sbjct: 183 AYARHTGQVGTKLYMSPEQIHGNS-YSHKVDIFSLGLILFELL---YPFSTQMERVRTLT 238 Query: 216 IFRALGTPNNEVWP---EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDL 263 R L P E +QD + P +P ++ + ++N LD Sbjct: 239 DVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAI-NIIENAVFEDLDF 288 >5AMN-A nrPDB Length = 299 Score = 188 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 64/288 (22%), Positives = 122/288 (42%), Gaps = 31/288 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRH-KTTGQ----VVAMKKIRLESEEEGVPSTAIREISLLK 56 ++ + +GEG +G V K G+ VA+K ++ E+ + E ++LK Sbjct: 23 KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENASPSELRDLLSEFNVLK 81 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDS-------IPPGQYMDSSLVKSY 108 ++ HP+++ L QD L LI E+ L+ +L P + + + S+ Sbjct: 82 QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISF 141 Query: 109 LYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV--T 166 +QI QG+ + +++HRDL +N+L+ + +K++DFGL+R Sbjct: 142 AWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIP 201 Query: 167 LWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFR---ALGT 222 + + + E L Y+T D+WS G + E+ T + G ++LF + + + Sbjct: 202 VKWMAIESLFDHI-YTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLLKTGHRMER 259 Query: 223 PNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIY 270 P+N + P +P + DL KM++ Sbjct: 260 PDNCSEEMYRLMLQCWKQEPDKRPV--------FADISKDL-EKMMVK 298 >5VD3-A nrPDB Length = 311 Score = 188 bits (478), Expect = 2e-48, Method: Composition-based stats. Identities = 70/283 (24%), Positives = 117/283 (41%), Gaps = 36/283 (12%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHPN 62 + ++ ++G G+YG V+K R K G++ A+K+ + + E+ +++ +HP Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 118 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 V L+ + LYL E L+++ ++ G + + V YL L + HS+ Sbjct: 119 CVRLEQAWEEGGILYLQTELCGPSLQQHCEAW--GASLPEAQVWGYLRDTLLALAHLHSQ 176 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 ++H D+KP N+ + +G KL DFGL G E Y +PE+L GS Y Sbjct: 177 GLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQE-GDPRYMAPELLQGS--YG 233 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 T D++S+G E+A L HG QL + Sbjct: 234 TAADVFSLGLTILEVACNMELPHGGEGWQQLRQ--------------------------- 266 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHP 285 + P + L +L ML DP R + + L P Sbjct: 267 GYLPPEFTA---GLSSELRSVLVMMLEPDPKLRATAEALLALP 306 >1AD5-A nrPDB Length = 438 Score = 188 bits (478), Expect = 2e-48, Method: Composition-based stats. Identities = 61/249 (24%), Positives = 110/249 (44%), Gaps = 20/249 (8%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E +K+G G +G V+ + + VA+K ++ S + E +++K L+H Sbjct: 182 ESLKLEKKLGAGQFGEVWMATYNKHTK-VAVKTMKPGSMS---VEAFLAEANVMKTLQHD 237 Query: 62 NIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 +V L V+ ++ +Y+I EF++ L +L S G + + QI +G+ F Sbjct: 238 KLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKS-DEGSKQPLPKLIDFSAQIAEGMAFIE 295 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 R +HRDL+ N+L+ K+ADFGLAR + + +PE + Sbjct: 296 QRNYIHRDLRAANILVSASLVCKIADFGLARV---------GAKFPIKWTAPEAI-NFGS 345 Query: 181 YSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPE--VESLQDY 237 ++ D+WS G + E+ T + + G S + + + R P E PE + Sbjct: 346 FTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRC 405 Query: 238 KNTFPKWKP 246 P+ +P Sbjct: 406 WKNRPEERP 414 >4H1J-A nrPDB Length = 293 Score = 188 bits (478), Expect = 2e-48, Method: Composition-based stats. Identities = 62/281 (22%), Positives = 111/281 (39%), Gaps = 39/281 (13%) Query: 2 EDYTKIEKIGEGTYGVVYKGR---HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL 58 ED +GEG +G VY+G HK VA+K + + + + E ++K L Sbjct: 24 EDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNL 82 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 HP+IV L ++ ++ ++I E +L YL+ + + Y QI + + Sbjct: 83 DHPHIVKLIGIIEEEPT-WIIMELYPYGELGHYLER--NKNSLKVLTLVLYSLQICKAMA 139 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTH-EVVTLWYRSPEVLL 176 + S +HRD+ +N+L+ +KL DFGL+R + + + SPE + Sbjct: 140 YLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESI- 198 Query: 177 GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 R++T D+W E+ + K F D + + + P ++ P V Sbjct: 199 NFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYT- 257 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI 276 L+++ YDP+ R Sbjct: 258 ---------------------------LMTRCWDYDPSDRP 271 >4R7H-A nrPDB Length = 343 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 55/310 (17%), Positives = 117/310 (37%), Gaps = 59/310 (19%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQV-----VAMKKIRLESEEEGVPSTAIREISLLK 56 + + +G G +G V + G+ VA+K ++ + + E+ ++ Sbjct: 50 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-STAHADEKEALMSELKIMS 108 Query: 57 EL-RHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSI-------------------- 94 L +H NIV+L + +I E+ + DL +L Sbjct: 109 HLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDK 168 Query: 95 PPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG 154 G+ ++ + + Q+ QG+ F S+ +HRD+ +N+L+ + K+ DFGLAR Sbjct: 169 EDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIM 228 Query: 155 IPIR--VYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEID 211 V + + + + +PE + S Y+ D+WS G + E+ + + G Sbjct: 229 NDSNYIVKGNARLPVKWMAPESIFDSV-YTVQSDVWSYGILLWEIFSLGLNPYPGILVNS 287 Query: 212 QLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYD 271 + +++ + Y+ P + P ++ S ++ + Sbjct: 288 KFYKLVK----------------DGYQMAQPAFAPKNIYS-----------IMQACWALE 320 Query: 272 PAKRISGKMA 281 P R + + Sbjct: 321 PTHRPTFQQI 330 >4HZS-A nrPDB Length = 341 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 67/273 (24%), Positives = 120/273 (43%), Gaps = 16/273 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHK-TTGQVV--AMKKIRLESEEE-GVPSTAIREISLLKE 57 +D +EK+G+G++GVV +G +G+ V A+K ++ + + IRE++ + Sbjct: 12 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 71 Query: 58 LRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQ-YMDSSLVKSYLYQILQGI 116 L H N++ L V++ + ++ E L LD + Q + + Y Q+ +G+ Sbjct: 72 LDHRNLIRLYGVVLTP-PMKMVTELAP--LGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM 128 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY---THEVVTLWYRSPE 173 + S+R +HRDL +NLL+ + +K+ DFGL RA Y H V + +PE Sbjct: 129 GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE 188 Query: 174 VLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRI---FRALGTPNNEVWP 229 L + +S D W G E+ T + + G + L +I L P + Sbjct: 189 SL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 247 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLD 262 + P+ +P +A L+ D Sbjct: 248 IYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTD 280 >5UIU-A nrPDB Length = 323 Score = 187 bits (476), Expect = 4e-48, Method: Composition-based stats. Identities = 60/199 (30%), Positives = 95/199 (47%), Gaps = 9/199 (4%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIR--LESEEEGVPSTAIREISLLKELRHPNIVSL 66 K+GEG +GVVYKG T VA+KK+ ++ E + +EI ++ + +H N+V L Sbjct: 54 KMGEGGFGVVYKGYVNNT--TVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVEL 111 Query: 67 QDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 125 L L++ ++ + L L + + + GI F H + Sbjct: 112 LGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHI 171 Query: 126 HRDLKPQNLLIDDKGTIKLADFGLARAFG--IPIRVYTHEVVTLWYRSPEVLLGSARYST 183 HRD+K N+L+D+ T K++DFGLARA + + V T Y +PE L G + Sbjct: 172 HRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEI--TP 229 Query: 184 PVDIWSIGTIFAELATKKP 202 DI+S G + E+ T P Sbjct: 230 KSDIYSFGVVLLEIITGLP 248 >2OZO-A nrPDB Length = 613 Score = 187 bits (476), Expect = 4e-48, Method: Composition-based stats. Identities = 56/255 (21%), Positives = 114/255 (44%), Gaps = 14/255 (5%) Query: 9 KIGEGTYGVVYKGRHKTTGQV--VAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 ++G G +G V +G ++ + VA+K ++ + E+ +RE ++ +L +P IV L Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRL 401 Query: 67 QDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 125 V ++ L L+ E L K+L + + + S V L+Q+ G+ + + + Sbjct: 402 IGVCQAEA-LMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 458 Query: 126 HRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV---TLWYRSPEVLLGSARYS 182 HR+L +N+L+ ++ K++DFGL++A G YT L + +PE + ++S Sbjct: 459 HRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKFS 517 Query: 183 TPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRI--FRALGTPNNEVWPEVESLQDYKN 239 + D+WS G E + + + + + I + + P + D Sbjct: 518 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWI 577 Query: 240 TFPKWKPGSLASHVK 254 + +P L + Sbjct: 578 YKWEDRPDFLTVEQR 592 >5GRN-A nrPDB Length = 356 Score = 187 bits (475), Expect = 5e-48, Method: Composition-based stats. Identities = 62/299 (20%), Positives = 116/299 (38%), Gaps = 43/299 (14%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQ-----VVAMKKIRLESEEEGVPSTAIREISLLK 56 + +G G +G V +G + VA+K ++ + + E+ ++ Sbjct: 46 DGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLK-PTARSSEKQALMSELKIMT 104 Query: 57 ELR-HPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPG----------------- 97 L H NIV+L + +Y+I E+ DL YL Sbjct: 105 HLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNL 164 Query: 98 ------QYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLAR 151 + + + S+ YQ+ +G+ F S+ +HRDL +N+L+ +K+ DFGLAR Sbjct: 165 LSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLAR 224 Query: 152 AFGIPIRV--YTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHG-- 206 + + + +PE + + Y+T D+WS G + E+ + + G Sbjct: 225 DIMHDSNYVSKGSTFLPVKWMAPESIFDNL-YTTLSDVWSYGILLWEIFSLGGTPYPGMM 283 Query: 207 -DSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLL 264 DS + + P++ E + N+ P+ +P +L E +LL Sbjct: 284 VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPS-----FYHLSEIVENLL 337 >1U59-A nrPDB Length = 287 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 57/255 (22%), Positives = 114/255 (44%), Gaps = 14/255 (5%) Query: 9 KIGEGTYGVVYKGRHKTTGQV--VAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 ++G G +G V +G ++ + VA+K ++ + E+ +RE ++ +L +P IV L Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRL 75 Query: 67 QDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 125 V ++ L L+ E L K+L + + + S V L+Q+ G+ + + + Sbjct: 76 IGVCQAEA-LMLVMEMAGGGPLHKFL--VGKREEIPVSNVAELLHQVSMGMKYLEEKNFV 132 Query: 126 HRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV---TLWYRSPEVLLGSARYS 182 HRDL +N+L+ ++ K++DFGL++A G YT L + +PE + ++S Sbjct: 133 HRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKFS 191 Query: 183 TPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRI--FRALGTPNNEVWPEVESLQDYKN 239 + D+WS G E + + + + + I + + P + D Sbjct: 192 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWI 251 Query: 240 TFPKWKPGSLASHVK 254 + +P L + Sbjct: 252 YKWEDRPDFLTVEQR 266 >2W1I-A nrPDB Length = 326 Score = 186 bits (474), Expect = 7e-48, Method: Composition-based stats. Identities = 71/288 (24%), Positives = 128/288 (44%), Gaps = 27/288 (9%) Query: 4 YTKIEKIGEGTYGVVYKGRHK----TTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR 59 ++++G+G +G V R+ TG+VVA+KK++ +EE REI +LK L+ Sbjct: 43 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE--HLRDFEREIEILKSLQ 100 Query: 60 HPNIVSLQDVLMQDSR--LYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 H NIV + V R L LI E+L L+ YL + +D + Y QI +G+ Sbjct: 101 HDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK--ERIDHIKLLQYTSQICKGM 158 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT---HEVVTLWYRSPE 173 + ++R +HRDL +N+L++++ +K+ DFGL + Y +++ +PE Sbjct: 159 EYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPE 218 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 233 L S ++S D+WS G + EL T + + R +G Sbjct: 219 SLTES-KFSVASDVWSFGVVLYELFT-----YIEKSKSPPAEFMRMIGNDKQGQMIVFHL 272 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 ++ KN +P + + +++ + +R S + Sbjct: 273 IELLKNNGRLPRPDGCPDEIYMI-------MTECWNNNVNQRPSFRDL 313 >4XUF-A nrPDB Length = 297 Score = 186 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 60/279 (21%), Positives = 107/279 (38%), Gaps = 35/279 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQ-----VVAMKKIRLESEEEGVPSTAIREISLLK 56 E+ + +G G +G V + VA+K ++ E + + E+ ++ Sbjct: 9 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK-EKADSSEREALMSELKMMT 67 Query: 57 ELR-HPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDS------------ 102 +L H NIV+L +YLIFE+ DL YL S D Sbjct: 68 QLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEE 127 Query: 103 --------SLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG 154 + + YQ+ +G+ F + +HRDL +N+L+ +K+ DFGLAR Sbjct: 128 EDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIM 187 Query: 155 IPIR--VYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHG---DS 208 V + + + + +PE L Y+ D+WS G + E+ + + G D+ Sbjct: 188 SDSNYVVRGNARLPVKWMAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDA 246 Query: 209 EIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPG 247 +L + + P +Q + +P Sbjct: 247 NFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPS 285 >3IO7-A nrPDB Length = 313 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 71/288 (24%), Positives = 128/288 (44%), Gaps = 27/288 (9%) Query: 4 YTKIEKIGEGTYGVVYKGRHK----TTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR 59 ++++G+G +G V R+ TG+VVA+KK++ +EE REI +LK L+ Sbjct: 30 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEE--HLRDFEREIEILKSLQ 87 Query: 60 HPNIVSLQDVLMQDSR--LYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 H NIV + V R L LI E+L L+ YL + +D + Y QI +G+ Sbjct: 88 HDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK--ERIDHIKLLQYTSQICKGM 145 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT---HEVVTLWYRSPE 173 + ++R +HRDL +N+L++++ +K+ DFGL + Y +++ +PE Sbjct: 146 EYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPE 205 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 233 L S ++S D+WS G + EL T + + R +G Sbjct: 206 SLTES-KFSVASDVWSFGVVLYELFT-----YIEKSKSPPAEFMRMIGNDKQGQMIVFHL 259 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 ++ KN +P + + +++ + +R S + Sbjct: 260 IELLKNNGRLPRPDGCPDEIYMI-------MTECWNNNVNQRPSFRDL 300 >5X02-A nrPDB Length = 347 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 60/279 (21%), Positives = 107/279 (38%), Gaps = 35/279 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQ-----VVAMKKIRLESEEEGVPSTAIREISLLK 56 E+ + +G G +G V + VA+K ++ E + + E+ ++ Sbjct: 48 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK-EKADSSEREALMSELKMMT 106 Query: 57 ELR-HPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDS------------ 102 +L H NIV+L +YLIFE+ DL YL S D Sbjct: 107 QLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEE 166 Query: 103 --------SLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG 154 + + YQ+ +G+ F + +HRDL +N+L+ +K+ DFGLAR Sbjct: 167 EDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIM 226 Query: 155 IPIR--VYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHG---DS 208 V + + + + +PE L Y+ D+WS G + E+ + + G D+ Sbjct: 227 SDSNYVVRGNARLPVKWMAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDA 285 Query: 209 EIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPG 247 +L + + P +Q + +P Sbjct: 286 NFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPS 324 >1U54-B nrPDB Length = 291 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 67/273 (24%), Positives = 120/273 (43%), Gaps = 16/273 (5%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHK-TTGQVV--AMKKIRLESEEE-GVPSTAIREISLLKE 57 +D +EK+G+G++GVV +G +G+ V A+K ++ + + IRE++ + Sbjct: 18 KDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHS 77 Query: 58 LRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQ-YMDSSLVKSYLYQILQGI 116 L H N++ L V++ + ++ E L LD + Q + + Y Q+ +G+ Sbjct: 78 LDHRNLIRLYGVVLTP-PMKMVTELAP--LGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM 134 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY---THEVVTLWYRSPE 173 + S+R +HRDL +NLL+ + +K+ DFGL RA Y H V + +PE Sbjct: 135 GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE 194 Query: 174 VLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRI---FRALGTPNNEVWP 229 L + +S D W G E+ T + + G + L +I L P + Sbjct: 195 SL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 253 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLD 262 + P+ +P +A L+ D Sbjct: 254 IYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTD 286 >5HI2-A nrPDB Length = 283 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 60/286 (20%), Positives = 114/286 (39%), Gaps = 39/286 (13%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 T ++IG G++G VYKG+ VA+K + E+ +L++ RH N Sbjct: 21 QITVGQRIGSGSFGTVYKGKWHGD---VAVKML-----TPQQLQAFKNEVGVLRKTRHVN 72 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 I+ +L ++ ++ L +L + + + Q +G+ + H+ Sbjct: 73 ILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHA--SETKFEMKKLIDIARQTARGMDYLHA 129 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHE--VVTLWYRSPEVL--LG 177 + ++HRDLK N+ + + T+K+ DFGLA + E ++ + +PEV+ Sbjct: 130 KSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQD 189 Query: 178 SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 S YS D+++ G + EL T + + + DQ I +G + Sbjct: 190 SNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ---IIEMVGRGSL------------ 234 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 L+ N + L+++ L +R S L Sbjct: 235 --------SPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILA 272 >4LRM-A nrPDB Length = 334 Score = 184 bits (468), Expect = 3e-47, Method: Composition-based stats. Identities = 62/273 (22%), Positives = 113/273 (41%), Gaps = 19/273 (6%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVV----AMKKIRLESEEEGVPSTAIREISLLKEL 58 ++ KI+ +G G +G VYKG G+ V A+K++R E+ + E ++ + Sbjct: 20 EFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASV 78 Query: 59 RHP---NIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 +P ++ L + + S + LI + + L Y+ + S + ++ QI + Sbjct: 79 DNPGNPHVCRLLGICLT-STVQLITQLMPFGCLLDYVREHKDN--IGSQYLLNWCVQIAK 135 Query: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV--TLWYRSP 172 G+ + RR++HRDL +N+L+ +K+ DFGLA+ G + Y E + + + Sbjct: 136 GMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMAL 195 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHG--DSEIDQLFRIFRALGTPNNEVWP 229 E +L Y+ D+WS G EL T + G SEI + L P Sbjct: 196 ESILHRI-YTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTID 254 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLD 262 + +P + + D Sbjct: 255 VYMIMVKCWMIDADSRPK-FRELIIEFSKMARD 286 >5HIE-A nrPDB Length = 302 Score = 184 bits (468), Expect = 3e-47, Method: Composition-based stats. Identities = 60/286 (20%), Positives = 115/286 (40%), Gaps = 39/286 (13%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 T ++IG G++G VYKG+ VA+K + E+ +L++ RH N Sbjct: 37 QITVGQRIGSGSFGTVYKGKWHGD---VAVKML-----TPQQLQAFKNEVGVLRKTRHVN 88 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 I+ +L ++ ++ + I ++ L+ Q QG+ + H++ Sbjct: 89 ILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLI-DIARQTAQGMDYLHAK 146 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHE--VVTLWYRSPEVL--LGS 178 ++HRDLK N+ + + T+K+ DFGLA + E ++ + +PEV+ Sbjct: 147 SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDK 206 Query: 179 ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQ-LFRIFRALGTPNNEVWPEVESLQDY 237 YS D+++ G + EL T + + + DQ +F + R +P+ Sbjct: 207 NPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPD------------- 253 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 L+ N + L+++ L +R L Sbjct: 254 -----------LSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILA 288 >4HVI-A nrPDB Length = 314 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 70/284 (24%), Positives = 120/284 (42%), Gaps = 28/284 (9%) Query: 4 YTKIEKIGEGTYGVVYKGRHK----TTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR 59 I ++G+G +G V R+ TG +VA+K+++ ++ REI +LK L Sbjct: 12 LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQ--QRDFQREIQILKALH 69 Query: 60 HPNIVSLQDVLMQDSR--LYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 IV + V R L L+ E+L S L+ +L +D+S + Y QI +G+ Sbjct: 70 SDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQR--HRARLDASRLLLYSSQICKGM 127 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHE---VVTLWYRSPE 173 + SRR +HRDL +N+L++ + +K+ADFGLA+ + Y +++ +PE Sbjct: 128 EYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPE 187 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 233 L + +S D+WS G + EL T + D R +G+ + Sbjct: 188 SLSDNI-FSRQSDVWSFGVVLYELFT-----YCDKSCSPSAEFLRMMGSERD-------- 233 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS 277 + + G +L+ P R S Sbjct: 234 VPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPS 277 >2X7G-A nrPDB Length = 389 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 94/366 (25%), Positives = 142/366 (38%), Gaps = 87/366 (23%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR--- 59 Y I K+G G + V+ + VAMK ++ + TA+ EI LLK +R Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK---SAQHYTETALDEIKLLKCVRESD 88 Query: 60 --HPN---IVSLQDVL----MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLY 110 PN +V L D M + ++FE L L K++ Q + VKS + Sbjct: 89 PSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIK-SNYQGLPVRCVKSIIR 147 Query: 111 QILQGIVFCHSR-RVLHRDLKPQNLLI--------------------------------- 136 Q+LQG+ + HS+ +++H D+KP+N+L+ Sbjct: 148 QVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTA 207 Query: 137 --------------DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 182 DK +K+AD G A + +T ++ T YRS EVL+G+ YS Sbjct: 208 PAADLLVNPLDPRNADKIRVKIADLGNACWVH---KHFTEDIQTRQYRSIEVLIGAG-YS 263 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDS------EIDQLFRIFRALGTPNNEVWPEVESLQD 236 TP DIWS + ELAT LF S + D + I LG+ + ++ Sbjct: 264 TPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSRE 323 Query: 237 YKNTFPKWKPGSLASHVKNLD-------------ENGLDLLSKMLIYDPAKRISGKMALN 283 + N + + + D D L ML P KR S L Sbjct: 324 FFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLR 383 Query: 284 HPYFND 289 HP+ N Sbjct: 384 HPWLNS 389 >5HVK-A nrPDB Length = 315 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 70/306 (22%), Positives = 125/306 (40%), Gaps = 46/306 (15%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D E +G+G +G K H+ TG+V+ MK++ +E T ++E+ +++ L HPN Sbjct: 15 DLIHGEVLGKGCFGQAIKVTHRETGEVMVMKEL--IRFDEETQRTFLKEVKVMRCLEHPN 72 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 ++ VL +D RL I E++ + + QY S S+ I G+ + HS Sbjct: 73 VLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQY-PWSQRVSFAKDIASGMAYLHSM 131 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGI--------------PIRVYTHEVVTLW 168 ++HR+L N L+ + + +ADFGLAR + V + Sbjct: 132 NIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPY 191 Query: 169 YRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVW 228 + +PE++ G + Y VD++S G + E+ I R P+ + Sbjct: 192 WMAPEMINGRS-YDEKVDVFSFGIVLCEI------------------IGRVNADPDY-LP 231 Query: 229 PEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 ++ + + ++ P + + DL DP KR S L H + Sbjct: 232 RTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDL-------DPEKRPSFVK-LEH-WLE 282 Query: 289 DLDNQI 294 L + Sbjct: 283 TLRMHL 288 >4WUA-A nrPDB Length = 401 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 94/368 (25%), Positives = 144/368 (39%), Gaps = 89/368 (24%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH-- 60 Y I K+G G + V+ + VAMK ++ E TA+ EI LLK +R+ Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK---SAEHYTETALDEIRLLKSVRNSD 98 Query: 61 PN------IVSLQDVLM----QDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLY 110 PN +V L D + + ++FE L L K++ Q + VK + Sbjct: 99 PNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIK-SNYQGLPLPCVKKIIQ 157 Query: 111 QILQGIVFCHSR-RVLHRDLKPQNLLID-------------------------------- 137 Q+LQG+ + H++ R++H D+KP+N+L+ Sbjct: 158 QVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTA 217 Query: 138 -----------------DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 +K +K+AD G A + +T ++ T YRS EVL+GS Sbjct: 218 PATAGNFLVNPLEPKNAEKLKVKIADLGNACWVH---KHFTEDIQTRQYRSLEVLIGSG- 273 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDS------EIDQLFRIFRALGTPNNEVWPEVESL 234 Y+TP DIWS + ELAT LF S + D + I LG ++ + Sbjct: 274 YNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYS 333 Query: 235 QDY------KNTFPKWKPGSLASHVKNLDEN-------GLDLLSKMLIYDPAKRISGKMA 281 +++ K KP L + E D L ML P KR + Sbjct: 334 KEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAEC 393 Query: 282 LNHPYFND 289 L HP+ N Sbjct: 394 LRHPWLNS 401 >5FM2-A nrPDB Length = 355 Score = 184 bits (467), Expect = 5e-47, Method: Composition-based stats. Identities = 64/302 (21%), Positives = 122/302 (40%), Gaps = 45/302 (14%) Query: 2 EDYTKIEKIGEGTYGVVYKGRH-KTTGQ----VVAMKKIRLESEEEGVPSTAIREISLLK 56 ++ + +GEG +G V K G+ VA+K ++ E+ + E ++LK Sbjct: 64 KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENASPSELRDLLSEFNVLK 122 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDS---------------------I 94 ++ HP+++ L QD L LI E+ L+ +L Sbjct: 123 QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH 182 Query: 95 PPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG 154 P + + + S+ +QI QG+ + +++HRDL +N+L+ + +K++DFGL+R Sbjct: 183 PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY 242 Query: 155 IPIRVYTHEVV--TLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEID 211 + + + E L Y+T D+WS G + E+ T + G + Sbjct: 243 EEDSYVKRSQGRIPVKWMAIESLFDHI-YTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPE 300 Query: 212 QLFRIFR---ALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKML 268 +LF + + + P+N + P +P + DL KM+ Sbjct: 301 RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPV--------FADISKDL-EKMM 351 Query: 269 IY 270 + Sbjct: 352 VK 353 >2JD5-A nrPDB Length = 373 Score = 183 bits (466), Expect = 7e-47, Method: Composition-based stats. Identities = 84/328 (25%), Positives = 133/328 (40%), Gaps = 49/328 (14%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP- 61 Y + K+G G + V+ + VAMK +R ++ A EI LL+ + Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR---GDKVYTEAAEDEIKLLQRVNDAD 76 Query: 62 ----------NIVSLQDVLMQDS----RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKS 107 +I+ L D + ++FE L +L + + + VK Sbjct: 77 NTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKY-EHRGIPLIYVKQ 135 Query: 108 YLYQILQGIVFCH-SRRVLHRDLKPQNLLI------DDKGTIKLADFGLARAFGIPIRVY 160 Q+L G+ + H ++H D+KP+N+L+ ++ IK+AD G A + Y Sbjct: 136 ISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYD---EHY 192 Query: 161 THEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDS------EIDQLF 214 T+ + T YRSPEVLLG A + DIWS + EL T LF D + D + Sbjct: 193 TNSIQTREYRSPEVLLG-APWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIA 251 Query: 215 RIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGS----------LASHVKNLDENGL--- 261 +I LG + + + + + N+ + S L K + Sbjct: 252 QIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEIS 311 Query: 262 DLLSKMLIYDPAKRISGKMALNHPYFND 289 D LS ML DP KR +NHP+ D Sbjct: 312 DFLSPMLQLDPRKRADAGGLVNHPWLKD 339 >5U6B-A nrPDB Length = 307 Score = 183 bits (465), Expect = 9e-47, Method: Composition-based stats. Identities = 61/295 (20%), Positives = 115/295 (38%), Gaps = 48/295 (16%) Query: 6 KIEKIGEGTYGVVYKGRHKTTG--QVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 + +GEG +G V +G+ VA+K +++ + E +KE HPN+ Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNV 86 Query: 64 VSLQDVLMQDSRL------YLIFEFLS-MDLKKYLDSIPPGQ---YMDSSLVKSYLYQIL 113 + L V Q S +I F+ DL +L G Y+ + ++ ++ I Sbjct: 87 MRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIA 146 Query: 114 QGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV--TLWYRS 171 G+ + ++R +HRDL +N ++++ ++ +ADFGL++ + + + + Sbjct: 147 SGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIA 206 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHG--DSEIDQLFRIFRALGTPNNEVW 228 E L Y++ D+WS G E+AT + + G +SEI R L P + + Sbjct: 207 IESLADRV-YTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCL- 264 Query: 229 PEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 + L+S+ +P R S Sbjct: 265 -----------------------------DGLYALMSRCWELNPQDRPSFTELRE 290 >4YFF-A nrPDB Length = 311 Score = 183 bits (464), Expect = 9e-47, Method: Composition-based stats. Identities = 59/255 (23%), Positives = 107/255 (41%), Gaps = 13/255 (5%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPSTAIREISLLKELR 59 + + E IG G++G VYKGR + ++VA+K+ R + + RE+S+L +L Sbjct: 41 LSEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN 98 Query: 60 HPNIVSLQDVLMQD-SRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 HP ++ + D S+ ++ +++S L L +D + +G+ Sbjct: 99 HPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKR--ILDLQSKLIIAVDVAKGME 156 Query: 118 FCHS--RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGI-PIRVYTHEVVTLWYRSPEV 174 + H+ + ++HRDL N+L+ + G +ADFG +R T + L + +PEV Sbjct: 157 YLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEV 216 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVW---PEV 231 RY+ D++S E+ T + F + P P Sbjct: 217 FTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPIS 276 Query: 232 ESLQDYKNTFPKWKP 246 L N P+ +P Sbjct: 277 SLLIRGWNACPEGRP 291 >5TOS-A nrPDB Length = 395 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 72/298 (24%), Positives = 124/298 (41%), Gaps = 33/298 (11%) Query: 3 DYTKIEKIGEGTYGVVYKG---------RHKTTGQVVAMKKIRLESEEEGVPSTAIREIS 53 ++ IGEG +G V+KG TG V+A+KK+ E + + EI+ Sbjct: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ--GHREWLTEIN 123 Query: 54 LLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKK--YLDSIPPGQYMDSSLVKSYLYQ 111 L +L HPN+V L ++D L++EF+ + + + L + Sbjct: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 Query: 112 ILQGIVFCHSR--RVLHRDLKPQNLLIDDKGTIKLADFGLARA--FGIPIRVYTHEVVTL 167 +G+ F HS +V++RD+K N+L+D KL+DFGLAR G V T + T Sbjct: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 Query: 168 WYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEI--DQLFRIFRALGTPNN 225 Y +PE + S + D++S G + E+ + K + + L R T Sbjct: 244 GYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 Query: 226 EVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 +V V++ D + P+ + V + L ++P R + + Sbjct: 303 KVLLIVDNRLDTQY-LPEEAVRMASVAV------------QCLSFEPKSRPTMDQVVR 347 >3ZBF-A nrPDB Length = 322 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 64/295 (21%), Positives = 119/295 (40%), Gaps = 49/295 (16%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKT-----TGQV-VAMKKIRLESEEEGVPSTAIREISLL 55 E T +G G +G VY+G +G++ VA+K ++ S ++ ++E L+ Sbjct: 33 EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIE-FLKEAHLM 91 Query: 56 KELRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDS----SLVKSYLY 110 + HPNI+ V + + Y+I E + DL YL + + Sbjct: 92 SKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCV 151 Query: 111 QILQGIVFCHSRRVLHRDLKPQNLLI-----DDKGTIKLADFGLARAF--GIPIRVYTHE 163 I +G V+ +HRDL +N L+ +K+ DFGLAR R Sbjct: 152 DISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEG 211 Query: 164 VVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGT 222 ++ + + +PE L+ ++T D+WS G + E+ T + S +D L Sbjct: 212 LLPVRWMAPESLMD-GIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVL--------- 261 Query: 223 PNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS 277 +Y T + +P +N ++ +L+++ +P +R + Sbjct: 262 -------------NYVQTGGRLEPP------RNCPDDLWNLMTQCWAQEPDQRPT 297 >3M42-A nrPDB Length = 299 Score = 182 bits (463), Expect = 1e-46, Method: Composition-based stats. Identities = 63/298 (21%), Positives = 106/298 (35%), Gaps = 64/298 (21%) Query: 1 MEDYTKI-EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLL-KEL 58 ++DY + +G G G V + +K T + A+K + A RE+ L + Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML-------QDCPKARREVELHWRAS 68 Query: 59 RHPNIVSLQDVLMQ----DSRLYLIFEFLSMDLKKYLDSIPPG--QYMDSSLVKSYLYQI 112 + P+IV + DV L ++ E L + I Q + I Sbjct: 69 QCPHIVRIVDVYENLYAGRKCLLIVMECLDGG--ELFSRIQDRGDQAFTEREASEIMKSI 126 Query: 113 LQGIVFCHSRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAFGIPIRVYTHEVVTLWY 169 + I + HS + HRD+KP+NLL +KL DFG A+ Sbjct: 127 GEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGE------------- 173 Query: 170 RSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 +Y D+WS+G I L P F+ + G + Sbjct: 174 ----------KYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPGMK 211 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 + Y+ P+W + E L+ +L +P +R++ +NHP+ Sbjct: 212 TRIRMGQYEFPNPEW---------SEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 260 >3C1X-A nrPDB Length = 373 Score = 182 bits (463), Expect = 1e-46, Method: Composition-based stats. Identities = 63/269 (23%), Positives = 120/269 (44%), Gaps = 17/269 (6%) Query: 8 EKIGEGTYGVVYKGRHK-TTGQV--VAMKKIRLESEEEGVPSTAIREISLLKELRHPNIV 64 E IG G +G VY G G+ A+K + + G S + E ++K+ HPN++ Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN-RITDIGEVSQFLTEGIIMKDFSHPNVL 153 Query: 65 SLQDVLMQ-DSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 SL + ++ + ++ ++ DL+ ++ + + + Q+ +G+ F S+ Sbjct: 154 SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNP--TVKDLIGFGLQVAKGMKFLASK 211 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFG----IPIRVYTHEVVTLWYRSPEVLLGS 178 + +HRDL +N ++D+K T+K+ADFGLAR + T + + + + E L + Sbjct: 212 KFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESL-QT 270 Query: 179 ARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEID--QLFRIFRALGTPNNEVWPEVESLQ 235 +++T D+WS G + EL T P + + D R L P P E + Sbjct: 271 QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVML 330 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLL 264 + + +P S + V + + Sbjct: 331 KCWHPKAEMRP-SFSELVSRISAIFSTFI 358 >2WTK-B nrPDB Length = 373 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 67/322 (20%), Positives = 116/322 (36%), Gaps = 31/322 (9%) Query: 4 YTKIEKIGEGTYG--VVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 Y + IG+G V R+K TG+ V +++I LE+ + + E+ + K HP Sbjct: 11 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 70 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 NIV + + D+ L+++ F++ K L M+ + L +L+ + + H Sbjct: 71 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 130 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVT---------LWYRSP 172 +HR +K ++LI G + L+ GL + VV L + SP Sbjct: 131 MGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSP 188 Query: 173 EVLLGS-ARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRAL--------GTP 223 EVL + Y DI+S+G ELA F L P Sbjct: 189 EVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIP 248 Query: 224 NNEV---------WPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAK 274 E+ + P + + + + + L +P Sbjct: 249 AEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDA 308 Query: 275 RISGKMALNHPYFNDLDNQIKK 296 R S LNH +F + + + Sbjct: 309 RPSASTLLNHSFFKQIKRRASE 330 >5HLW-A nrPDB Length = 299 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 119/269 (44%), Gaps = 17/269 (6%) Query: 8 EKIGEGTYGVVYKGR---HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIV 64 E IG G +G VY G + A+K + + G S + E ++K+ HPN++ Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN-RITDIGEVSQFLTEGIIMKDFSHPNVL 84 Query: 65 SLQDVLMQ-DSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 SL + ++ + ++ ++ DL+ ++ + + + Q+ +G+ + S+ Sbjct: 85 SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNP--TVKDLIGFGLQVAKGMKYLASK 142 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGI----PIRVYTHEVVTLWYRSPEVLLGS 178 + +HRDL +N ++D+K T+K+ADFGLAR + T + + + + E L + Sbjct: 143 KFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESL-QT 201 Query: 179 ARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEID--QLFRIFRALGTPNNEVWPEVESLQ 235 +++T D+WS G + EL T P + + D R L P P E + Sbjct: 202 QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVML 261 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLL 264 + + +P S + V + + Sbjct: 262 KCWHPKAEMRP-SFSELVSRISAIFSTFI 289 >3ZZW-A nrPDB Length = 289 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 67/266 (25%), Positives = 121/266 (45%), Gaps = 26/266 (9%) Query: 6 KIEKIGEGTYGVVYKGRHK-----TTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 +E++GE +G VYKG Q VA+K ++ + E + E L L+H Sbjct: 13 FMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLK-DKAEGPLREEFRHEAMLRARLQH 71 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYL-------------DSIPPGQYMDSSLVK 106 PN+V L V+ +D L +IF + S DL ++L D ++ Sbjct: 72 PNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFV 131 Query: 107 SYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFG--IPIRVYTHEV 164 + QI G+ + S V+H+DL +N+L+ DK +K++D GL R ++ + + Sbjct: 132 HLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSL 191 Query: 165 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEID--QLFRIFRALG 221 + + + +PE ++ ++S DIWS G + E+ + + G S D ++ R + L Sbjct: 192 LPIRWMAPEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLP 250 Query: 222 TPNNEVWPEVESLQDYKNTFPKWKPG 247 P++ + + N FP +P Sbjct: 251 CPDDCPAWVYALMIECWNEFPSRRPR 276 >3G0E-A nrPDB Length = 336 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 60/307 (19%), Positives = 111/307 (36%), Gaps = 54/307 (17%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQ-----VVAMKKIRLESEEEGVPSTAIREISLLK 56 + + +G G +G V + + VA+K ++ S + E+ +L Sbjct: 46 NRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK-PSAHLTEREALMSELKVLS 104 Query: 57 EL-RHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPG---------------QY 99 L H NIV+L +I E+ DL +L Sbjct: 105 YLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELA 164 Query: 100 MDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR- 158 +D + S+ YQ+ +G+ F S+ +HRDL +N+L+ K+ DFGLAR Sbjct: 165 LDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNY 224 Query: 159 -VYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRI 216 V + + + + +PE + Y+ D+WS G EL + + G + +++ Sbjct: 225 VVKGNARLPVKWMAPESIFNCV-YTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKM 283 Query: 217 FRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI 276 + + ++ P+ P D++ DP KR Sbjct: 284 IK----------------EGFRMLSPEHAPA-----------EMYDIMKTCWDADPLKRP 316 Query: 277 SGKMALN 283 + K + Sbjct: 317 TFKQIVQ 323 >2A1A-B nrPDB Length = 284 Score = 181 bits (459), Expect = 4e-46, Method: Composition-based stats. Identities = 70/297 (23%), Positives = 120/297 (40%), Gaps = 57/297 (19%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D+ +IE IG G +G V+K +H+ G+ +K+++ +E+ A RE+ L +L H N Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEK------AEREVKALAKLDHVN 65 Query: 63 IVSLQDVL----------------MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVK 106 IV + L++ EF + G+ +D L Sbjct: 66 IVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLAL 125 Query: 107 SYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVT 166 QI +G+ + HS+++++RDLKP N+ + D +K+ DFGL + + T T Sbjct: 126 ELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGK-RTRSKGT 184 Query: 167 LWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNE 226 L Y SPE + S Y VD++++G I AEL Sbjct: 185 LRYMSPEQI-SSQDYGKEVDLYALGLILAELL---------------------------- 215 Query: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 ++ + F + G ++ ++ LL K+L P R + L Sbjct: 216 --HVCDTAFETSKFFTDLRDGIISDIFDKKEKT---LLQKLLSKKPEDRPNTSEILR 267 >4X7Q-B nrPDB Length = 312 Score = 180 bits (458), Expect = 5e-46, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 110/295 (37%), Gaps = 47/295 (15%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVP----STAIREISLLKEL 58 +Y +G+G +G V+ G T VA+K I P T E++LL ++ Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 59 R----HPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 HP ++ L D L+ E + + D I + + + Q++ Sbjct: 92 GAGGGHPGVIRLLDWFETQEGFMLVLE-RPLPAQDLFDYITEKGPLGEGPSRCFFGQVVA 150 Query: 115 GIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 173 I CHSR V+HRD+K +N+LID +G KL DFG YT T Y PE Sbjct: 151 AIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHD--EPYTDFDGTRVYSPPE 208 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 233 + ++ P +WS+G + ++ F D EI + F A Sbjct: 209 WISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPA-------------- 254 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 ++ + L+ + L P+ R S + L P+ Sbjct: 255 ---------------------HVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQ 288 >4NEU-A nrPDB Length = 333 Score = 180 bits (458), Expect = 5e-46, Method: Composition-based stats. Identities = 55/289 (19%), Positives = 111/289 (38%), Gaps = 41/289 (14%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D+ + ++ G +G V H+T G ++ MK + + E ++ LRH Sbjct: 25 DFLESAELDSGGFGKVSLCFHRTQGLMI-MKTVYKGPNCIEHNEALLEEAKMMNRLRHSR 83 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 +V L V++++ + L+ E++ + + S+ + +I++G+ + H + Sbjct: 84 VVKLLGVIIEEGKYSLVMEYMEKG--NLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGK 141 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLA-------------RAFGIPIRVYTHEVVTLWY 169 V+H+DLKP+N+L+D+ IK+AD GLA TL+Y Sbjct: 142 GVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYY 201 Query: 170 RSPEVLLG-SARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVW 228 +PE L +A+ + D++S + + K + QL ++ P+ + Sbjct: 202 MAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDI 261 Query: 229 PEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS 277 E + L+ +P R + Sbjct: 262 TEY------------------------CPREIISLMKLCWEANPEARPT 286 >3LLT-A nrPDB Length = 360 Score = 180 bits (458), Expect = 6e-46, Method: Composition-based stats. Identities = 74/332 (22%), Positives = 121/332 (36%), Gaps = 55/332 (16%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 + I K+G+GT+G V +H + A+K +R + +A E +LK++++ +I Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVR---NIKKYTRSAKIEADILKKIQNDDI 93 Query: 64 -----VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 V M + LIFE L L + + +K Y +IL+ + + Sbjct: 94 NNNNIVKYHGKFMYYDHMCLIFEPLGPSLYEIITR-NNYNGFHIEDIKLYCIEILKALNY 152 Query: 119 CHSRRVLHRDLKPQNLLIDDKGT-------------------------IKLADFGLARAF 153 + H DLKP+N+L+DD IKL DFG A Sbjct: 153 LRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATF- 211 Query: 154 GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQL 213 + + T YR+PEV+L + D+WS G + AEL T LF ++ L Sbjct: 212 --KSDYHGSIINTRQYRAPEVILNLG-WDVSSDMWSFGCVLAELYTGSLLFRTHEHMEHL 268 Query: 214 FRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLD---------------- 257 + + + E K + + +++ Sbjct: 269 AMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYKIIK 328 Query: 258 -ENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 E D L +L DP R S L H + Sbjct: 329 HELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >3QUP-A nrPDB Length = 323 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 60/292 (20%), Positives = 114/292 (39%), Gaps = 45/292 (15%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTG---QVVAMKKIRLESEEEGVPSTAIREISLLKEL 58 + +T +G+G +G V + + K VA+K ++ + +RE + +KE Sbjct: 23 QQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEF 82 Query: 59 RHPNIVSLQDVLMQ---DSRL---YLIFEFLS-MDLKKYLDSIPPGQY---MDSSLVKSY 108 HP++ L V ++ RL +I F+ DL +L + G+ + + + Sbjct: 83 DHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRF 142 Query: 109 LYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTHEVVT 166 + I G+ + SR +HRDL +N ++ + T+ +ADFGL+R G R + Sbjct: 143 MVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLP 202 Query: 167 LWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNN 225 + + + E L + Y+ D+W+ G E+ T + + G + + Sbjct: 203 VKWLALESLADNL-YTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLI-------- 253 Query: 226 EVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS 277 G+ E DL+ + DP +R S Sbjct: 254 --------------------GGNRLKQPPECMEEVYDLMYQCWSADPKQRPS 285 >5O0Y-A nrPDB Length = 579 Score = 178 bits (452), Expect = 2e-45, Method: Composition-based stats. Identities = 66/294 (22%), Positives = 114/294 (38%), Gaps = 46/294 (15%) Query: 15 YGVVYKGRHKTTGQVVAMKKIRL-----ESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 + VYK T + VA+K +L + ++E A RE + KEL HP IV L D Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 70 L-MQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR--VLH 126 + + E+ + + + + M +S + QI+ + + + + ++H Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFY--LKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIH 414 Query: 127 RDLKPQNLLIDDK---GTIKLADFGLARAFGIPI-------RVYTHEVVTLWYRSPEVLL 176 DLKP N+L+ + G IK+ DFGL++ + + T WY PE + Sbjct: 415 YDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFV 474 Query: 177 ---GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVES 233 + S VD+WS+G IF + + F G ++ Q ++ E Sbjct: 475 VGKEPPKISNKVDVWSVGVIFYQCLYGRKPF-GHNQSQQ-------------DILQENTI 520 Query: 234 LQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287 L+ + FP + + + L Y RI + PY Sbjct: 521 LKATEVQFPPK---------PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 565 >4C59-A nrPDB Length = 340 Score = 178 bits (451), Expect = 3e-45, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 119/299 (39%), Gaps = 58/299 (19%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHPNIVSL 66 + EG + VY+ + +G+ A+K++ S EE I+E+ +K+L HPNIV Sbjct: 33 RVLAEGGFAFVYEAQDVGSGREYALKRLL--SNEEEKNRAIIQEVCFMKKLSGHPNIVQF 90 Query: 67 --------QDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 ++ + L+ E L ++L + + V YQ + + Sbjct: 91 CSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQH 150 Query: 119 CHSRR--VLHRDLKPQNLLIDDKGTIKLADFGLARAFGI-PIRVYTHEV----------- 164 H ++ ++HRDLK +NLL+ ++GTIKL DFG A P ++ + Sbjct: 151 MHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRN 210 Query: 165 VTLWYRSPEVLLGSARY--STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGT 222 T YR+PE++ + + DIW++G I L ++ F +++ Sbjct: 211 TTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKL------------ 258 Query: 223 PNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 + + K + P H L+ ML +P +R+S Sbjct: 259 ----------RIVNGKYSIPPHDTQYTVFH---------SLIRAMLQVNPEERLSIAEV 298 >3AOX-A nrPDB Length = 344 Score = 177 bits (450), Expect = 4e-45, Method: Composition-based stats. Identities = 57/264 (21%), Positives = 101/264 (38%), Gaps = 20/264 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGR-----HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLK 56 ++ T I +G G +G VY+G+ + + VA+K + E E + E ++ Sbjct: 47 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-EVCSEQDELDFLMEALIIS 105 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLV----KSYLYQ 111 + H NIV V +Q +++ E + DLK +L P SSL Sbjct: 106 KFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARD 165 Query: 112 ILQGIVFCHSRRVLHRDLKPQNLLIDDKG---TIKLADFGLARAFGIPIRVYTHEV--VT 166 I G + +HRD+ +N L+ G K+ DFG+AR + Sbjct: 166 IACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLP 225 Query: 167 LWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRA--LGTP 223 + + PE + +++ D WS G + E+ + + S + L + + P Sbjct: 226 VKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPP 284 Query: 224 NNEVWPEVESLQDYKNTFPKWKPG 247 N P + P+ +P Sbjct: 285 KNCPGPVYRIMTQCWQHQPEDRPN 308 >6CTH-A nrPDB Length = 309 Score = 177 bits (450), Expect = 4e-45, Method: Composition-based stats. Identities = 53/204 (25%), Positives = 96/204 (47%), Gaps = 10/204 (4%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 ++ K+GEG +G VY+G + + +A+KK+ S + E+ ++ LRH N Sbjct: 16 NFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRAS--KQGIKEYASEVKIISRLRHKN 73 Query: 63 IVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +V L + L L++EF+ + L ++ + + + + +++ H Sbjct: 74 LVKLIGWCHERGELMLVYEFMANGSLDSHI--FKGKSLLTWEVRYRIVKDLASALLYLHE 131 Query: 122 RR---VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTH-EVVTLWYRSPEVLLG 177 VLHRD+K N+++D KL DFGLAR + T+ Y +PE L Sbjct: 132 EGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECL-S 190 Query: 178 SARYSTPVDIWSIGTIFAELATKK 201 S + S D++S G + E+A+ + Sbjct: 191 SGKASKESDVYSFGVVALEIASGR 214 >4TPT-A nrPDB Length = 303 Score = 177 bits (450), Expect = 4e-45, Method: Composition-based stats. Identities = 61/218 (27%), Positives = 100/218 (45%), Gaps = 27/218 (12%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D E +G+G +G K HK TG+V+ MK++ +E T + E+ +++ L HPN Sbjct: 1 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKEL--IRCDEETQKTFLTEVKVMRSLDHPN 58 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 ++ VL +D +L L+ E++ LK +L S+ P + I G+ + HS Sbjct: 59 VLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDP---FPWQQKVRFAKGIASGMAYLHS 115 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--------------------GIPIRVYT 161 ++HRDL N LI T+ +ADFGL+R + Sbjct: 116 MCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRY 175 Query: 162 HEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT 199 V ++ +PE+L G + Y VDI+S G + E+ Sbjct: 176 TVVGNPYWMAPEMLNGKS-YDETVDIFSFGIVLCEIIG 212 >3PLS-A nrPDB Length = 298 Score = 176 bits (448), Expect = 7e-45, Method: Composition-based stats. Identities = 66/280 (23%), Positives = 124/280 (44%), Gaps = 42/280 (15%) Query: 8 EKIGEGTYGVVYKGRHKTTGQ---VVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIV 64 IG+G +GVVY G + Q A+K + +E + V +RE L++ L HPN++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQV-EAFLREGLLMRGLNHPNVL 85 Query: 65 SLQDVLMQDSRL-YLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 +L +++ L +++ ++ DL +++ S + S+ Q+ +G+ + + Sbjct: 86 ALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNP--TVKDLISFGLQVARGMEYLAEQ 143 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGI----PIRVYTHEVVTLWYRSPEVLLGS 178 + +HRDL +N ++D+ T+K+ADFGLAR ++ + H + + + + E L Sbjct: 144 KFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTY 203 Query: 179 ARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 R++T D+WS G + EL T P + D + + P Sbjct: 204 -RFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQ------------- 249 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS 277 P++ P SL + + DPA R + Sbjct: 250 ----PEYCPDSLYQV-----------MQQCWEADPAVRPT 274 >3Q4U-A nrPDB Length = 301 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 70/308 (22%), Positives = 111/308 (36%), Gaps = 58/308 (18%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D T +E +G+G YG V++G + G+ VA+K E+ T + +L RH N Sbjct: 9 DITLLECVGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSWFRETELYNTVML---RHEN 63 Query: 63 IVSLQDVLMQDSR----LYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 I+ M L+LI + L YL +D+ + I G+ Sbjct: 64 ILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLT----TLDTVSCLRIVLSIASGLA 119 Query: 118 FCH--------SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY----THEVV 165 H + HRDLK +N+L+ G +AD GLA V Sbjct: 120 HLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVG 179 Query: 166 TLWYRSPEVLLGSARYS-----TPVDIWSIGTIFAELATK----------KPLFHGDSEI 210 T Y +PEVL + + VDIW+ G + E+A + KP F+ Sbjct: 180 TKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPN 239 Query: 211 DQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIY 270 D P+ E +V + + P L L+ + Sbjct: 240 D-----------PSFEDMRKVVCVDQQRPNIPNRWFSD-----PTLTSLAK-LMKECWYQ 282 Query: 271 DPAKRISG 278 +P+ R++ Sbjct: 283 NPSARLTA 290 >4FL3-A nrPDB Length = 635 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 56/256 (21%), Positives = 120/256 (46%), Gaps = 18/256 (7%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHK--TTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL 58 +ED +++G G +G V KG ++ + VA+K ++ E+ + + + E +++++L Sbjct: 372 LED----KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQL 427 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117 +P IV + + +S + L+ E + L KYL +++ + ++Q+ G+ Sbjct: 428 DNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQ---NRHVKDKNIIELVHQVSMGMK 483 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY---THEVVTLWYRSPEV 174 + +HRDL +N+L+ + K++DFGL++A Y TH + + +PE Sbjct: 484 YLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC 543 Query: 175 LLGSARYSTPVDIWSIGTIFAELAT-KKPLFHG--DSEIDQLFRIFRALGTPNNEVWPEV 231 + ++S+ D+WS G + E + + + G SE+ + +G P Sbjct: 544 I-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 602 Query: 232 ESLQDYKNTFPKWKPG 247 + + + +PG Sbjct: 603 DLMNLCWTYDVENRPG 618 >3UIU-A nrPDB Length = 306 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 70/310 (22%), Positives = 120/310 (38%), Gaps = 70/310 (22%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 D+ +IE IG G +G V+K +H+ G+ +++++ +E+ A RE+ L +L H N Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEK------AEREVKALAKLDHVN 66 Query: 63 IVSLQDVL-----------------------------MQDSRLYLIFEFLSMDLKKYLDS 93 IV + L++ EF + Sbjct: 67 IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIE 126 Query: 94 IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF 153 G+ +D L QI +G+ + HS++++HRDLKP N+ + D +K+ DFGL + Sbjct: 127 KRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL 186 Query: 154 GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQL 213 + T TL Y SPE + S Y VD++++G I AEL Sbjct: 187 KNDGK-RTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELL--------------- 229 Query: 214 FRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPA 273 ++ + F + G ++ ++ LL K+L P Sbjct: 230 ---------------HVCDTAFETSKFFTDLRDGIISDIFDKKEKT---LLQKLLSKKPE 271 Query: 274 KRISGKMALN 283 R + L Sbjct: 272 DRPNTSEILR 281 >4Y83-A nrPDB Length = 332 Score = 175 bits (445), Expect = 1e-44, Method: Composition-based stats. Identities = 60/279 (21%), Positives = 99/279 (35%), Gaps = 33/279 (11%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 I G +G VY + T + +A K I ++ + + + RH NI L Sbjct: 81 IPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD-------VEIQACFRHENIAELYGA 133 Query: 70 LMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDL 129 ++ ++L E + + L+ + M + +L+G+ F HS++V+H D+ Sbjct: 134 VLWGETVHLFME--AGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDI 191 Query: 130 KPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWS 189 KP N++ + L DFGL+ + T Y SPEV+L ST DI+S Sbjct: 192 KPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGH-STKADIYS 249 Query: 190 IGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSL 249 +G + T P + Y K P L Sbjct: 250 LGATLIHMQTGTPPWVKRYPRSAY---------------------PSYLYIIHKQAPP-L 287 Query: 250 ASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 288 + +L+ L +P R L H N Sbjct: 288 EDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALN 326 >6B2Q-A nrPDB Length = 317 Score = 175 bits (444), Expect = 2e-44, Method: Composition-based stats. Identities = 58/224 (25%), Positives = 92/224 (41%), Gaps = 12/224 (5%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE-SEEEGVPSTAIREISLLKELRHP 61 Y I G G V++ G+ VA+K ++ E S + E L HP Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 92 Query: 62 NIVSLQDVLM-----QDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 I S+ D + YL+ E ++ + L L + L Q + Sbjct: 93 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR---LSLRHALDMLEQTGRA 149 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV-VTLWYRSPEV 174 + H+ ++HRD+KP N+LI G +K+ DFG+A+A T V T Y +PE Sbjct: 150 LQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQ 209 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 218 LG S D++S+G + E + K F GD + + + Sbjct: 210 ALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK 252 >4X3F-A nrPDB Length = 337 Score = 175 bits (444), Expect = 2e-44, Method: Composition-based stats. Identities = 58/224 (25%), Positives = 92/224 (41%), Gaps = 12/224 (5%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE-SEEEGVPSTAIREISLLKELRHP 61 Y I G G V++ G+ VA+K ++ E S + E L HP Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 72 Query: 62 NIVSLQDVLM-----QDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 I S+ D + YL+ E ++ + L L + L Q + Sbjct: 73 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR---LSLRHALDMLEQTGRA 129 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV-VTLWYRSPEV 174 + H+ ++HRD+KP N+LI G +K+ DFG+A+A T V T Y +PE Sbjct: 130 LQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQ 189 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 218 LG S D++S+G + E + K F GD + + + Sbjct: 190 ALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK 232 >4OW8-A nrPDB Length = 283 Score = 175 bits (444), Expect = 2e-44, Method: Composition-based stats. Identities = 58/224 (25%), Positives = 92/224 (41%), Gaps = 12/224 (5%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE-SEEEGVPSTAIREISLLKELRHP 61 Y I G G V++ G+ VA+K ++ E S + E L HP Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHP 71 Query: 62 NIVSLQDVLM-----QDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 I S+ D + YL+ E ++ + L L + L Q + Sbjct: 72 GIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR---LSLRHALDMLEQTGRA 128 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV-VTLWYRSPEV 174 + H+ ++HRD+KP N+LI G +K+ DFG+A+A T V T Y +PE Sbjct: 129 LQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQ 188 Query: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 218 LG S D++S+G + E + K F GD + + + Sbjct: 189 ALGHDA-SPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIK 231 >3MDY-A nrPDB Length = 337 Score = 175 bits (444), Expect = 2e-44, Method: Composition-based stats. Identities = 73/299 (24%), Positives = 124/299 (41%), Gaps = 38/299 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + +++IG+G YG V+ G+ + G+ VA+K E T I + L+ RH Sbjct: 37 KQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASWFRETEIYQTVLM---RHE 91 Query: 62 NIVSLQDVLMQDS----RLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 NI+ ++ + +LYLI ++ + L YL S +D+ + Y + G+ Sbjct: 92 NILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKST----TLDAKSMLKLAYSSVSGL 147 Query: 117 VFCH--------SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY----THEV 164 H + HRDLK +N+L+ GT +AD GLA F V Sbjct: 148 CHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRV 207 Query: 165 VTLWYRSPEVL---LGSARYSTP--VDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA 219 T Y PEVL L + + D++S G I E+A ++ + G E QL Sbjct: 208 GTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVA-RRCVSGGIVEEYQLPYHDLV 266 Query: 220 LGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG 278 P+ E E+ ++ + +FP L+++ ++PA R++ Sbjct: 267 PSDPSYEDMREIVCIKKLRPSFPNRWSSD------ECLRQMGKLMTECWAHNPASRLTA 319 >6J5U-C nrPDB Length = 426 Score = 175 bits (444), Expect = 2e-44, Method: Composition-based stats. Identities = 66/294 (22%), Positives = 119/294 (40%), Gaps = 27/294 (9%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTT---------GQVVAMKKIRLESEEEGVPSTAIREI 52 +++ + +GEG +G V+KG T G VVA+K+++ E + + E+ Sbjct: 84 KNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQ--GHKEWLTEV 141 Query: 53 SLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQI 112 + L +L HPN+V L + L++EF+ + Q + ++ Sbjct: 142 NYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGA 201 Query: 113 LQGIVFCHSRR--VLHRDLKPQNLLIDDKGTIKLADFGLARA--FGIPIRVYTHEVVTLW 168 +G+ F H + V++RD K N+L+D KL+DFGLA+A G V T + T Sbjct: 202 AKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHG 261 Query: 169 YRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVW 228 Y +PE + + R + D++S G + EL + + + ++ + A Sbjct: 262 YAAPEYV-ATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWA--------- 311 Query: 229 PEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMAL 282 L D + F + + +L + L D R L Sbjct: 312 --TPYLGDKRKLFRIMDTKLGGQYPQKGAFTAANLALQCLNPDAKLRPKMSEVL 363 >4PL5-B nrPDB Length = 435 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 77/301 (25%), Positives = 125/301 (41%), Gaps = 48/301 (15%) Query: 8 EKIGEGTYGV-VYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR-HPNIVS 65 + +G G G VYKG + VA+K+I E S A RE+ LL+E HPN++ Sbjct: 33 DVLGHGAEGTIVYKGMF--DNRDVAVKRILPECF-----SFADREVQLLRESDEHPNVIR 85 Query: 66 LQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 125 Y+ E + L++Y++ + L+Q G+ HS ++ Sbjct: 86 YFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPIT--LLHQTTSGLAHLHSLNIV 143 Query: 126 HRDLKPQNLLI---DDKGTIK--LADFGLARAFGIPIRVYTHEVV---TLWYRSPEVLLG 177 HRDLKP N+L+ + G IK ++DFGL + + ++ T + +PE+L Sbjct: 144 HRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSE 203 Query: 178 SARY--STPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 + + VDI+S G +F + + F +SL Sbjct: 204 DCKDNPTYTVDIFSAGCVFYYVISEGYHPF--------------------------GKSL 237 Query: 235 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294 Q N K+ D +L+ KM+ DP +R S K L HP+F L+ Q+ Sbjct: 238 QRQANILLGACNLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQL 297 Query: 295 K 295 + Sbjct: 298 Q 298 >2RIO-A nrPDB Length = 434 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 76/318 (23%), Positives = 137/318 (43%), Gaps = 61/318 (19%) Query: 8 EKIGEGTYG-VVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR-HPNIVS 65 + +G G+ G VV++G + G+ VA+K++ ++ + A+ EI LL E HPN++ Sbjct: 21 KILGYGSSGTVVFQGSFQ--GRPVAVKRMLIDFCD-----IALMEIKLLTESDDHPNVIR 73 Query: 66 LQDVLMQDSRLYLIFEFLSMDLKKYLDSIP----PGQYMDSSLVKSYLYQILQGIVFCHS 121 D LY+ E +++L+ ++S + S L QI G+ HS Sbjct: 74 YYCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHS 133 Query: 122 RRVLHRDLKPQNLLID-------------DKGTIKLADFGLARAFGIPIRVY----THEV 164 +++HRDLKPQN+L+ + I ++DFGL + + + Sbjct: 134 LKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPS 193 Query: 165 VTLWYRSPEVLLGS------ARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIF 217 T +R+PE+L S R + +DI+S+G +F + + K F + + I Sbjct: 194 GTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF--GDKYSRESNII 251 Query: 218 RALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS 277 R + + + H ++L DL+S+M+ +DP KR + Sbjct: 252 RGIFSLDEMKCL----------------------HDRSLIAEATDLISQMIDHDPLKRPT 289 Query: 278 GKMALNHPYFNDLDNQIK 295 L HP F +++ Sbjct: 290 AMKVLRHPLFWPKSKKLE 307 >5U6C-A nrPDB Length = 315 Score = 174 bits (441), Expect = 5e-44, Method: Composition-based stats. Identities = 59/258 (22%), Positives = 112/258 (43%), Gaps = 18/258 (6%) Query: 6 KIEKIGEGTYGVVYKGRHKT---TGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 + +GEG +G V +G K T VA+K ++L++ + + E + +K+ HPN Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPN 99 Query: 63 IVSLQDVLMQDS-----RLYLIFEFLS-MDLKKYL---DSIPPGQYMDSSLVKSYLYQIL 113 ++ L V ++ S + +I F+ DL YL +++ + ++ I Sbjct: 100 VMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIA 159 Query: 114 QGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV--TLWYRS 171 G+ + +R LHRDL +N ++ D T+ +ADFGL++ + + + + Sbjct: 160 LGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIA 219 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHG--DSEIDQLFRIFRALGTPNNEVW 228 E L Y++ D+W+ G E+AT + G + E+ L P + + Sbjct: 220 IESLADRV-YTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLD 278 Query: 229 PEVESLQDYKNTFPKWKP 246 E + T P +P Sbjct: 279 ELYEIMYSCWRTDPLDRP 296 >2PMN-X nrPDB Length = 348 Score = 173 bits (440), Expect = 6e-44, Method: Composition-based stats. Identities = 59/314 (18%), Positives = 115/314 (36%), Gaps = 36/314 (11%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVP--------------- 45 + DY I + +G + + + A+KK E+ Sbjct: 30 INDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKY 87 Query: 46 STAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSI------PPGQY 99 E+ ++ ++++ ++ + ++ +Y+I+E++ D D + Sbjct: 88 DDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCF 147 Query: 100 MDSSLVKSYLYQILQGIVFCH-SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR 158 + ++K + +L + H + + HRD+KP N+L+D G +KL+DFG + + Sbjct: 148 IPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVD--K 205 Query: 159 VYTHEVVTLWYRSPEVLLGSARY-STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIF 217 T + PE + Y VDIWS+G + F + +LF Sbjct: 206 KIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKISLVELFNNI 265 Query: 218 RALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS 277 R +E D + L +D L L +PA+RI+ Sbjct: 266 RT---------KNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERIT 316 Query: 278 GKMALNHPYFNDLD 291 + AL H + D + Sbjct: 317 SEDALKHEWLADTN 330 >6HV0-A nrPDB Length = 416 Score = 172 bits (437), Expect = 1e-43, Method: Composition-based stats. Identities = 78/301 (25%), Positives = 124/301 (41%), Gaps = 48/301 (15%) Query: 8 EKIGEGTYGV-VYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR-HPNIVS 65 + +G G G VY+G + VA+K+I E S A RE+ LL+E HPN++ Sbjct: 14 DVLGHGAEGTIVYRGMF--DNRDVAVKRILPECF-----SFADREVQLLRESDEHPNVIR 66 Query: 66 LQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 125 Y+ E + L++Y++ + L Q G+ HS ++ Sbjct: 67 YFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPIT--LLQQTTSGLAHLHSLNIV 124 Query: 126 HRDLKPQNLLI---DDKGTIK--LADFGLARAFGIPIRVYTHEVV---TLWYRSPEVLLG 177 HRDLKP N+LI + G IK ++DFGL + + ++ T + +PE+L Sbjct: 125 HRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSE 184 Query: 178 SARY--STPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234 + + VDI+S G +F + + F +SL Sbjct: 185 DCKENPTYTVDIFSAGCVFYYVISEGSHPF--------------------------GKSL 218 Query: 235 QDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294 Q N K+ D +L+ KM+ DP KR S K L HP+F L+ Q+ Sbjct: 219 QRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQL 278 Query: 295 K 295 + Sbjct: 279 Q 279 >5C26-A nrPDB Length = 299 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 54/249 (21%), Positives = 117/249 (46%), Gaps = 14/249 (5%) Query: 8 EKIGEGTYGVVYKGRHK--TTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVS 65 +++G G +G V KG ++ + VA+K ++ E+ + + + E +++++L +P IV Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVR 92 Query: 66 LQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV 124 + + +S + L+ E + L KYL +++ + ++Q+ G+ + Sbjct: 93 MIGICEAESWM-LVMEMAELGPLNKYLQQ---NRHVKDKNIIELVHQVSMGMKYLEESNF 148 Query: 125 LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY---THEVVTLWYRSPEVLLGSARY 181 +HRDL +N+L+ + K++DFGL++A Y TH + + +PE + ++ Sbjct: 149 VHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI-NYYKF 207 Query: 182 STPVDIWSIGTIFAELAT-KKPLFHG--DSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 S+ D+WS G + E + + + G SE+ + +G P + + Sbjct: 208 SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCW 267 Query: 239 NTFPKWKPG 247 + +PG Sbjct: 268 TYDVENRPG 276 >5WNL-A nrPDB Length = 342 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 58/286 (20%), Positives = 116/286 (40%), Gaps = 34/286 (11%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 ++ EK+G G +G VYK RH +A+K ++ + E ++ + Sbjct: 21 EFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRY 80 Query: 63 IVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH- 120 I+ + + + + L+ E++ L+K L S P + L +++ G+ F H Sbjct: 81 ILPVYGICQE--PVGLVMEYMETGSLEKLLASEP----LPWDLRFRIVHETAVGMNFLHC 134 Query: 121 -SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR---VYTHEVVTLWYRSPEVLL 176 S +LH +LKP N+L+D +K++DFGLA+ G+ T+ Y PE + Sbjct: 135 MSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIR 194 Query: 177 GSAR-YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 +R + T D++S + + T+K F + I + + ++ Sbjct: 195 EKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMM----------------KVVK 238 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 ++ P + + + L+ + DP R + + Sbjct: 239 GHRPELPP-----ICRPRPRACASLIGLMQRCWHADPQVRPTFQEI 279 >5WNO-A nrPDB Length = 330 Score = 170 bits (432), Expect = 5e-43, Method: Composition-based stats. Identities = 58/269 (21%), Positives = 108/269 (40%), Gaps = 22/269 (8%) Query: 8 EKIGEGTYGVVYKG-----RHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 +K+G G +G V+ G R K VA+K + ++ + E + + LRH N Sbjct: 28 KKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQ---TDQSQTDEMLEEATNMFRLRHDN 84 Query: 63 IVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 ++ + M D L ++ + +L+ +L + + Y YQI G+ + Sbjct: 85 LLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKEN--LGAREQVLYCYQIASGMQYLEK 142 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV--TLWYRSPEVLLGSA 179 +RV+HRDL +N+L+ +++ DFGL++ T + + + + E + Sbjct: 143 QRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIE-IFSKH 201 Query: 180 RYSTPVDIWSIGTIFAELAT-KKPLFHG--DSEIDQLFRIFRALGTPNNEVWPEVESLQD 236 Y+ D+W+ G E+ T + + G I + L P N + L Sbjct: 202 CYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLR 261 Query: 237 YKNTFPKWKPGSLASHVKNLDENGLDLLS 265 PK +PG + L E + Sbjct: 262 CWMADPKSRPG-----FEILYERFKEFCK 285 >4F9B-A nrPDB Length = 361 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 71/346 (20%), Positives = 131/346 (37%), Gaps = 68/346 (19%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTT---GQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 + +KIGEGT+ VY + + +A+K + P E+ L Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHL----IPTSHPIRIAAELQCLTVAGG 78 Query: 61 P-NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 N++ ++ ++ + + +L + +LD + + V+ Y+ + + + Sbjct: 79 QDNVMGVKYCFRKNDHVVIAMPYLEHE--SFLDILNS---LSFQEVREYMLNLFKALKRI 133 Query: 120 HSRRVLHRDLKPQNLLIDDK-GTIKLADFGLARAFGIPI--------------------- 157 H ++HRD+KP N L + + L DFGLA+ Sbjct: 134 HQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKC 193 Query: 158 -------RVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFH-GDSE 209 + T +R+PEVL +T +D+WS G IF L + + F+ + Sbjct: 194 SICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDD 253 Query: 210 IDQLFRIFRALGT--------------------PNNEVWPEVESLQDYKNTFPKWKP--- 246 + L +I G+ P ++ E L+ ++ PK Sbjct: 254 LTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQ 313 Query: 247 --GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 + + + DLL K+L +PA RI+ + AL HP+F D+ Sbjct: 314 GHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDM 359 >3G2F-A nrPDB Length = 336 Score = 166 bits (422), Expect = 7e-42, Method: Composition-based stats. Identities = 78/313 (24%), Positives = 131/313 (41%), Gaps = 47/313 (15%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 +++ +E IG G YG VYKG + VA+K + + + I + L++ H Sbjct: 12 LDNLKLLELIGRGRYGAVYKGS--LDERPVAVKVFSFANRQNFINEKNIYRVPLME---H 66 Query: 61 PNIVSLQ---DVLMQDSRL--YLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQ 114 NI + + D R+ L+ E+ + L KYL D + + + Sbjct: 67 DNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYL----SLHTSDWVSSCRLAHSVTR 122 Query: 115 GIVFCH---------SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--------GIPI 157 G+ + H + HRDL +N+L+ + GT ++DFGL+ G Sbjct: 123 GLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEED 182 Query: 158 RVYTHEVVTLWYRSPEVLLGSARYS------TPVDIWSIGTIFAELATKKP-LFHGDSEI 210 EV T+ Y +PEVL G+ VD++++G I+ E+ + LF G+S Sbjct: 183 NAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVP 242 Query: 211 D-QLFRIFRALGTPNNEVWPEVESLQDYKNTFPK-WKPGSLASHVKNLDENGLDLLSKML 268 + Q+ P E + S + + FP+ WK SLA V++L E D Sbjct: 243 EYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLA--VRSLKETIED----CW 296 Query: 269 IYDPAKRISGKMA 281 D R++ + A Sbjct: 297 DQDAEARLTAQCA 309 >4IDT-A nrPDB Length = 356 Score = 166 bits (422), Expect = 8e-42, Method: Composition-based stats. Identities = 63/279 (22%), Positives = 103/279 (36%), Gaps = 42/279 (15%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 ++G G++G V++ K TG A+KK+RLE E+ L P IV L Sbjct: 81 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRA-------EELMACAGLTSPRIVPLYG 133 Query: 69 VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 + + + + E L L + + YL Q L+G+ + HSRR+LH D Sbjct: 134 AVREGPWVNIFMELLEGGSLGQL--VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGD 191 Query: 129 LKPQNLLIDDKG-TIKLADFGLARAFGIPI---RVYTHEV--VTLWYRSPEVLLGSARYS 182 +K N+L+ G L DFG A + T + T + +PEV+LG + Sbjct: 192 VKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRS-CD 250 Query: 183 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFP 242 VD+WS + + + Q FR L + Sbjct: 251 AKVDVWSSCCMMLHMLNGCHPW------TQFFRGPLCLKIAS------------------ 286 Query: 243 KWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 +P + + + + L +P R+S Sbjct: 287 --EPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAEL 323 >3VHK-A nrPDB Length = 368 Score = 166 bits (421), Expect = 9e-42, Method: Composition-based stats. Identities = 67/334 (20%), Positives = 122/334 (36%), Gaps = 81/334 (24%) Query: 2 EDYTKIEKIGEGTYGVVYK----GRHKT-TGQVVAMKKIRLESEEEGVPSTAIREISLLK 56 + + +G G +G V + G KT T + VA+K ++ E + E+ +L Sbjct: 29 DRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK-EGATHSEHRALMSELKILI 87 Query: 57 ELRHP-NIVSLQDVLMQDSRLYLIF------------------EFLSM------------ 85 + H N+V+L + ++ EF+ Sbjct: 88 HIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKD 147 Query: 86 -------DLKKYLDSIPP----------------------------GQYMDSSLVKSYLY 110 DLK+ LDSI ++ + Y + Sbjct: 148 YVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSF 207 Query: 111 QILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV--YTHEVVTLW 168 Q+ +G+ F SR+ +HRDL +N+L+ +K +K+ DFGLAR + L Sbjct: 208 QVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLK 267 Query: 169 YRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHG---DSEIDQLFRIFRALGTPN 224 + +PE + Y+ D+WS G + E+ + + G D E + + + P+ Sbjct: 268 WMAPETIFDRV-YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPD 326 Query: 225 NEVWPEVESLQDYKNTFPKWKP--GSLASHVKNL 256 +++ D + P +P L H+ NL Sbjct: 327 YTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNL 360 >3UIM-A nrPDB Length = 326 Score = 166 bits (420), Expect = 1e-41, Method: Composition-based stats. Identities = 51/209 (24%), Positives = 100/209 (47%), Gaps = 9/209 (4%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++++ +G G +G VYKGR G +VA+K+++ E + G E+ ++ H Sbjct: 30 DNFSNKNILGRGGFGKVYKGRL-ADGTLVAVKRLKEERTQGGELQ-FQTEVEMISMAVHR 87 Query: 62 NIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQY-MDSSLVKSYLYQILQGIVFC 119 N++ L+ M + L++ ++ + + L P Q +D + +G+ + Sbjct: 88 NLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYL 147 Query: 120 HSR---RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV-VTLWYRSPEVL 175 H +++HRD+K N+L+D++ + DFGLA+ T V T+ + +PE L Sbjct: 148 HDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYL 207 Query: 176 LGSARYSTPVDIWSIGTIFAELATKKPLF 204 + + S D++ G + EL T + F Sbjct: 208 -STGKSSEKTDVFGYGVMLLELITGQRAF 235 >3MY0-A nrPDB Length = 305 Score = 166 bits (420), Expect = 1e-41, Method: Composition-based stats. Identities = 66/305 (21%), Positives = 105/305 (34%), Gaps = 58/305 (19%) Query: 6 KIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVS 65 +E +G+G YG V++G G+ VA+K E+ T EI LRH NI+ Sbjct: 12 LVECVGKGRYGEVWRGLWH--GESVAVKIFSSRDEQSWFRET---EIYNTVLLRHDNILG 66 Query: 66 LQDVLMQD----SRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 M ++L+LI + L +L Q ++ L G+ H Sbjct: 67 FIASDMTSRNSSTQLWLITHYHEHGSLYDFLQR----QTLEPHLALRLAVSAACGLAHLH 122 Query: 121 --------SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY----THEVVTLW 168 + HRD K +N+L+ +AD GLA V T Sbjct: 123 VEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKR 182 Query: 169 YRSPEVLLGSARYS-----TPVDIWSIGTIFAELATK----------KPLFHGDSEIDQL 213 Y +PEVL R DIW+ G + E+A + +P F+ D Sbjct: 183 YMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPND-- 240 Query: 214 FRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPA 273 P+ E +V + T P L ++ + +P+ Sbjct: 241 ---------PSFEDMKKVVCVDQQTPTIPNRLAAD-----PVLSGLA-QMMRECWYPNPS 285 Query: 274 KRISG 278 R++ Sbjct: 286 ARLTA 290 >5LPZ-A nrPDB Length = 332 Score = 166 bits (420), Expect = 1e-41, Method: Composition-based stats. Identities = 57/207 (27%), Positives = 92/207 (44%), Gaps = 11/207 (5%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 + IG G +G VYK K G VA+KK+ S + + E+ + +++H N+ Sbjct: 19 FHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGD--REFMAEMETIGKIKHRNL 75 Query: 64 VSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPP-GQYMDSSLVKSYLYQILQGIVFCH- 120 V L L++EF+ L+ L G ++ S + +G+ F H Sbjct: 76 VPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHH 135 Query: 121 --SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY--THEVVTLWYRSPEVLL 176 S ++HRD+K N+L+D+ +++DFG+AR + T Y PE Sbjct: 136 NCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYY- 194 Query: 177 GSARYSTPVDIWSIGTIFAELATKKPL 203 S R ST D++S G + EL T K Sbjct: 195 QSFRCSTKGDVYSYGVVLLELLTGKRP 221 >5LPV-A nrPDB Length = 296 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 57/207 (27%), Positives = 92/207 (44%), Gaps = 11/207 (5%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 + IG G +G VYK K G VA+KK+ S + + E+ + +++H N+ Sbjct: 19 FHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGD--REFMAEMETIGKIKHRNL 75 Query: 64 VSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPP-GQYMDSSLVKSYLYQILQGIVFCH- 120 V L L++EF+ L+ L G ++ S + +G+ F H Sbjct: 76 VPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHH 135 Query: 121 --SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY--THEVVTLWYRSPEVLL 176 S ++HRD+K N+L+D+ +++DFG+AR + T Y PE Sbjct: 136 NCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYY- 194 Query: 177 GSARYSTPVDIWSIGTIFAELATKKPL 203 S R ST D++S G + EL T K Sbjct: 195 QSFRCSTKGDVYSYGVVLLELLTGKRP 221 >3LMG-A nrPDB Length = 344 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 55/270 (20%), Positives = 109/270 (40%), Gaps = 16/270 (5%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQ----VVAMKKIRLESEEEGVPSTAIREISLLKEL 58 + K++ +G G +G V+KG G+ V +K I +S + + +++ L Sbjct: 32 ELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAI-GSL 90 Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQY-MDSSLVKSYLYQILQGIV 117 H +IV L + S L L+ ++L L LD + + + L+ ++ QI +G+ Sbjct: 91 DHAHIVRLLGLC-PGSSLQLVTQYLP--LGSLLDHVRQHRGALGPQLLLNWGVQIAKGMY 147 Query: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--VYTHEVVTLWYRSPEVL 175 + ++HR+L +N+L+ +++ADFG+A + +Y+ + + + E + Sbjct: 148 YLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESI 207 Query: 176 LGSARYSTPVDIWSIGTIFAELAT-KKPLFHG--DSEIDQLFRIFRALGTPNNEVWPEVE 232 +Y+ D+WS G EL T + G +E+ L L P Sbjct: 208 -HFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYM 266 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLD 262 + +P + D Sbjct: 267 VMVKCWMIDENIRP-TFKELANEFTRMARD 295 >1PY5-A nrPDB Length = 326 Score = 164 bits (415), Expect = 5e-41, Method: Composition-based stats. Identities = 67/294 (22%), Positives = 110/294 (37%), Gaps = 36/294 (12%) Query: 6 KIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVS 65 E IG+G +G V++G+ + G+ VA+K E EI LRH NI+ Sbjct: 33 LQESIGKGRFGEVWRGKWR--GEEVAVKIFSSREERSWFREA---EIYQTVMLRHENILG 87 Query: 66 LQDVLMQDS----RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH- 120 +D+ +L+L+ ++ D + ++K G+ H Sbjct: 88 FIAADNKDNGTWTQLWLVSDYHEHG--SLFDYLNRYTVTVEGMIK-LALSTASGLAHLHM 144 Query: 121 -------SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY----THEVVTLWY 169 + HRDLK +N+L+ GT +AD GLA H V T Y Sbjct: 145 EIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRY 204 Query: 170 RSPEVLLGSARYS-----TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPN 224 +PEVL S DI+++G +F E+A + + G E QL P+ Sbjct: 205 MAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPS 263 Query: 225 NEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG 278 E +V Q + P + L ++ + + A R++ Sbjct: 264 VEEMRKVVCEQKLRPNIPNR-----WQSCEALRVMAK-IMRECWYANGAARLTA 311 >2QKW-B nrPDB Length = 321 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 64/277 (23%), Positives = 112/277 (40%), Gaps = 20/277 (7%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 IG G +G VYKG + G VA+K R E EI L RHP++VSL Sbjct: 47 IGHGVFGKVYKGVLR-DGAKVALK--RRTPESSQGIEEFETEIETLSFCRHPHLVSLIGF 103 Query: 70 LMQDSRLYLIFEFL-SMDLKKYLD-SIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHR 127 + + + LI++++ + +LK++L S P M +G+ + H+R ++HR Sbjct: 104 CDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAIIHR 163 Query: 128 DLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV--VTLWYRSPEVLLGSARYSTPV 185 D+K N+L+D+ K+ DFG+++ + + V TL Y PE + R + Sbjct: 164 DVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFI-KGRLTEKS 222 Query: 186 DIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWK 245 D++S G + E+ + + + R + + Q + P Sbjct: 223 DVYSFGVVLFEVLCARS--------AIVQSLPREMVNLAEWAVESHNNGQLEQIVDPNLA 274 Query: 246 PGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMAL 282 ++ + + K L R S L Sbjct: 275 DKIRPESLRKFGDTAV----KCLALSSEDRPSMGDVL 307 >4LQP-A nrPDB Length = 508 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 48/158 (30%), Positives = 76/158 (48%), Gaps = 3/158 (1%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-RLESEEEGVPSTAIREISLLKELRH 60 ED+ ++ IG+G +G V + K TG++ AMK + + E ++ + E +L Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDS 161 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 P +VSL LYLI EFL + + Q + + Y+ + + I H Sbjct: 162 PWVVSLYYSFQDAQYLYLIMEFLPGG--DLMTMLIRWQLFTEDVTRFYMAECILAIETIH 219 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR 158 +HR +KP N+LID +G IKL+DFGL+ F Sbjct: 220 KLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHD 257 Score = 88.4 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 24/135 (17%), Positives = 44/135 (32%), Gaps = 31/135 (22%) Query: 162 HEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG 221 V T Y +PE+ L Y D WS+G I E P F ++ + +I Sbjct: 322 STVGTPDYIAPEIFL-YQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMN--- 377 Query: 222 TPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI----S 277 ++ ++ DL+ ++L + +R+ Sbjct: 378 ----------------------FEQTLQFPDDIHISYEAEDLIRRLLTH-ADQRLGRHGG 414 Query: 278 GKMALNHPYFNDLDN 292 +HP+F +D Sbjct: 415 ADEIKSHPFFRGVDW 429 >5XD6-A nrPDB Length = 305 Score = 161 bits (409), Expect = 2e-40, Method: Composition-based stats. Identities = 55/214 (25%), Positives = 98/214 (45%), Gaps = 17/214 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 ++Y IGEG+YG V+ G K +G+ A+KK+ + + + ++S++ LR Sbjct: 22 DNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPD---QEFLAQVSMVSRLRQE 77 Query: 62 NIVSLQDVLMQDSRLYLIFEFL-SMDLKKYLDSI------PPGQYMDSSLVKSYLYQILQ 114 N+V+L + L +E+ + L L PG + + Sbjct: 78 NVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAAR 137 Query: 115 GIVFCHSR---RVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEV-VTLWY 169 G+ + H + V+HRD+K N+L+ D K+ADF L+ + R+++ V T Y Sbjct: 138 GLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGY 197 Query: 170 RSPEVLLGSARYSTPVDIWSIGTIFAELATKKPL 203 +PE + + ST D++S G + EL T + Sbjct: 198 HAPEYAM-TGTLSTKSDVYSFGVVLLELLTGRKP 230 >4JLC-A nrPDB Length = 657 Score = 160 bits (406), Expect = 5e-40, Method: Composition-based stats. Identities = 66/284 (23%), Positives = 106/284 (37%), Gaps = 24/284 (8%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 +G+G V++GRHK TG + A+K S V +RE +LK+L H NIV L + Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 74 Query: 70 LMQDS--RLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 + + LI EF L L+ + S L ++ G+ ++H Sbjct: 75 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 134 Query: 127 RDLKPQNLL--IDDKGT--IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL------ 176 RD+KP N++ I + G KL DFG AR + T Y P++ Sbjct: 135 RDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRK 193 Query: 177 -GSARYSTPVDIWSIGTIFAELATKKPLFH----GDSEIDQLFRIFRALGTPNNEVWPEV 231 +Y VD+WS+G F AT F + +++I + + Sbjct: 194 DHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKA 253 Query: 232 ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLL----SKMLIYD 271 E+ + L ++L K +D Sbjct: 254 ENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFD 297 >4G3E-A nrPDB Length = 352 Score = 160 bits (406), Expect = 6e-40, Method: Composition-based stats. Identities = 53/203 (26%), Positives = 89/203 (43%), Gaps = 18/203 (8%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 68 ++G G++G V++ + K TG A+KK+RLE + E+ L P IV L Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFR-------VEELVACAGLSSPRIVPLYG 133 Query: 69 VLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHR 127 + + + + E L L + + + + YL Q L+G+ + H+RR+LH Sbjct: 134 AVREGPWVNIFMELLEGGSLGQLIKQM---GCLPEDRALYYLGQALEGLEYLHTRRILHG 190 Query: 128 DLKPQNLLIDDKG-TIKLADFGLARAFGIPI---RVYTHEV--VTLWYRSPEVLLGSARY 181 D+K N+L+ G L DFG A + T + T + +PEV++G Sbjct: 191 DVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGK-PC 249 Query: 182 STPVDIWSIGTIFAELATKKPLF 204 VDIWS + + + Sbjct: 250 DAKVDIWSSCCMMLHMLNGCHPW 272 >3SOC-A nrPDB Length = 322 Score = 160 bits (406), Expect = 6e-40, Method: Composition-based stats. Identities = 61/292 (20%), Positives = 118/292 (40%), Gaps = 28/292 (9%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 +E G +G V+K + + VA+K ++ ++ E+ L ++H NI Sbjct: 26 LQLLEVKARGRFGCVWKAQLL--NEYVAVKIFPIQDKQSWQNE---YEVYSLPGMKHENI 80 Query: 64 VSLQDVLMQDS----RLYLIFEFLS-MDLKKYLD----SIPPGQYMDSSLVK--SYLYQI 112 + + + L+LI F L +L S ++ ++ + +YL++ Sbjct: 81 LQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHED 140 Query: 113 LQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTHEVVTLWYR 170 + G+ H + HRD+K +N+L+ + T +ADFGLA F G +V T Y Sbjct: 141 IPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYM 200 Query: 171 SPEVLLGSARYST----PVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNE 226 +PEVL G+ + +D++++G + ELA++ G + L P+ E Sbjct: 201 APEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLE 260 Query: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG 278 EV + + + + + + +D R+S Sbjct: 261 DMQEVVVHKKKRPVLRDYWQKHAGMAMLCET------IEECWDHDAEARLSA 306 >2BUJ-A nrPDB Length = 317 Score = 160 bits (405), Expect = 7e-40, Method: Composition-based stats. Identities = 65/307 (21%), Positives = 119/307 (38%), Gaps = 51/307 (16%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + Y I+K+GEG + V G A+K+I E+ A RE + + HP Sbjct: 29 KHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRIL--CHEQQDREEAQREADMHRLFNHP 86 Query: 62 NIVSLQDVLMQDS----RLYLIFEFLS-MDLKKYLDSIP-PGQYMDSSLVKSYLYQILQG 115 NI+ L +++ +L+ F L ++ + G ++ + L I +G Sbjct: 87 NILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRG 146 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR---------VYTHEVVT 166 + H++ HRDLKP N+L+ D+G L D G I + + + T Sbjct: 147 LEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCT 206 Query: 167 LWYRSPEVLLGSARY--STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPN 224 + YR+PE+ + D+WS+G + + + + +F+ + Sbjct: 207 ISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYD---------MVFQKGDSVA 257 Query: 225 NEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKR------ISG 278 V ++ Q +++ W+ LL+ M+ DP +R +S Sbjct: 258 LAVQNQLSIPQSPRHSSALWQ-----------------LLNSMMTVDPHQRPHIPLLLSQ 300 Query: 279 KMALNHP 285 AL P Sbjct: 301 LEALQPP 307 >4EUU-A nrPDB Length = 319 Score = 160 bits (405), Expect = 7e-40, Method: Composition-based stats. Identities = 64/252 (25%), Positives = 101/252 (40%), Gaps = 21/252 (8%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 +G+G V++GRHK TG + A+K S V +RE +LK+L H NIV L + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 75 Query: 70 LMQDS--RLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 + + LI EF L L+ + S L ++ G+ ++H Sbjct: 76 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 135 Query: 127 RDLKPQNLL--IDDKGT--IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL------ 176 R++KP N++ I + G KL DFG AR + T Y P++ Sbjct: 136 RNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRK 194 Query: 177 -GSARYSTPVDIWSIGTIFAELATKKPLFH----GDSEIDQLFRIFRALGTPNNEVWPEV 231 +Y VD+WSIG F AT F + +++I + + Sbjct: 195 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKA 254 Query: 232 ESLQ-DYKNTFP 242 E+ D+ P Sbjct: 255 ENGPIDWSGDMP 266 >5AR8-A nrPDB Length = 326 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 61/290 (21%), Positives = 109/290 (37%), Gaps = 20/290 (6%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRL-ESEEEGVPSTAIREISLLKELRHPNIVS 65 + + G G V RH VA+K + + + +RE +L + R I+ Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILP 96 Query: 66 LQDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR- 123 + + + L ++ E++ + L + L + L L++I G+ + H+ Sbjct: 97 ILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTP 156 Query: 124 -VLHRDLKPQNLLIDDKGTIKLADFGLAR-----AFGIPIRVYTHEVVTLWYRSPEVLL- 176 +LH DLK QN+L+D++ +K+ADFGL++ E T+ Y PE Sbjct: 157 PLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEP 216 Query: 177 -GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQ 235 +R S DI+S I E+ ++K F + Q+ P E Sbjct: 217 GQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVIN-----EESL 271 Query: 236 DYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKR----ISGKMA 281 Y + S + L ++ +P R I+ A Sbjct: 272 PYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEA 321 >4EUT-A nrPDB Length = 396 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 64/252 (25%), Positives = 101/252 (40%), Gaps = 21/252 (8%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 +G+G V++GRHK TG + A+K S V +RE +LK+L H NIV L + Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 75 Query: 70 LMQDS--RLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 + + LI EF L L+ + S L ++ G+ ++H Sbjct: 76 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 135 Query: 127 RDLKPQNLL--IDDKGT--IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL------ 176 R++KP N++ I + G KL DFG AR + T Y P++ Sbjct: 136 RNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRK 194 Query: 177 -GSARYSTPVDIWSIGTIFAELATKKPLFH----GDSEIDQLFRIFRALGTPNNEVWPEV 231 +Y VD+WSIG F AT F + +++I + + Sbjct: 195 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKA 254 Query: 232 ESLQ-DYKNTFP 242 E+ D+ P Sbjct: 255 ENGPIDWSGDMP 266 >4F0G-A nrPDB Length = 287 Score = 158 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 66/277 (23%), Positives = 121/277 (43%), Gaps = 29/277 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVP-----STAIREISLLK 56 + ++IG+G +G+V+KGR VVA+K + L E RE+ ++ Sbjct: 19 NEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMS 78 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEFLS-MDL-KKYLDSIPPGQYMDSSLVKSYLYQILQ 114 L HPNIV L ++ R ++ EF+ DL + LD P + S+ + I Sbjct: 79 NLNHPNIVKLYGLMHNPPR--MVMEFVPCGDLYHRLLDKAHP---IKWSVKLRLMLDIAL 133 Query: 115 GIVFCHSRR--VLHRDLKPQNLL---IDDKGTI--KLADFGLARAFGIPIRVYTHEVVTL 167 GI + ++ ++HRDL+ N+ +D+ + K+ADFGL++ + + + Sbjct: 134 GIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ---SVHSVSGLLGNF 190 Query: 168 WYRSPEVL-LGSARYSTPVDIWSIGTIFAELATKKPLF----HGDSEIDQLFRIFRALGT 222 + +PE + Y+ D +S I + T + F +G + + R T Sbjct: 191 QWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPT 250 Query: 223 PNNEVWPEVES-LQDYKNTFPKWKPGSLASHVKNLDE 258 + P + + ++ + PK +P + VK L E Sbjct: 251 IPEDCPPRLRNVIELCWSGDPKKRP-HFSYIVKELSE 286 >2Y4I-B nrPDB Length = 319 Score = 156 bits (396), Expect = 8e-39, Method: Composition-based stats. Identities = 65/301 (21%), Positives = 119/301 (39%), Gaps = 38/301 (12%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 E E IG+G +G VY GR VA++ I +E + E RE+ ++ RH Sbjct: 32 FEQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIERDNEDQLKAFKREVMAYRQTRH 88 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 N+V M L +I L + +D + + +I++G+ + Sbjct: 89 ENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRD--AKIVLDVNKTRQIAQEIVKGMGYL 146 Query: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGL-----ARAFGIPIRVYTHEVVTLWYRSPEV 174 H++ +LH+DLK +N+ D G + + DFGL G + L + +PE+ Sbjct: 147 HAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEI 205 Query: 175 L--------LGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNE 226 + +S D++++GTI+ EL ++ F ++++ + PN Sbjct: 206 IRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGM-KPNLS 264 Query: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPA--KRISGKMALNH 284 + + D ++ + K +D ML P +R+S H Sbjct: 265 QIGMGKEISDILLFCWAFEQEERPTFTKLMD---------MLEKLPKRNRRLS------H 309 Query: 285 P 285 P Sbjct: 310 P 310 >6O8B-A nrPDB Length = 665 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 61/231 (26%), Positives = 95/231 (41%), Gaps = 20/231 (8%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 +G+G V++GRHK TG + A+K S V +RE +LK+L H NIV L + Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 81 Query: 70 LMQDS--RLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 + + LI EF L L+ + S L ++ G+ ++H Sbjct: 82 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 141 Query: 127 RDLKPQNLL--IDDKGT--IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL------ 176 R++KP N++ I + G KL DFG AR + T Y P++ Sbjct: 142 RNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVELYGTEEYLHPDMYERAVLRK 200 Query: 177 -GSARYSTPVDIWSIGTIFAELATKKPLFH----GDSEIDQLFRIFRALGT 222 +Y VD+WSIG F AT F + +++I + Sbjct: 201 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 251 >5TE0-A nrPDB Length = 347 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 65/293 (22%), Positives = 113/293 (38%), Gaps = 54/293 (18%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHPNIVSL 66 E + EG + +V+ R + G A+K++ + +E + REI ++++L H NIV Sbjct: 25 EVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHD--LQVCKREIQIMRDLSGHKNIVGY 81 Query: 67 QDVLMQDS------RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 D + + + ++ +F L + + V + + H Sbjct: 82 IDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLH 141 Query: 121 SRR--VLHRDLKPQNLLIDDKGTIKLADFGLA-RAFGIPIRVYTHEV-------VTLWYR 170 + ++HRDLK +N+L+ D+G L DFG A F P + V TL YR Sbjct: 142 QCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYR 201 Query: 171 SPEV--LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVW 228 +PE+ L +T DIW++G + +L F G+S++ Sbjct: 202 APEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF-GESQV------------------ 242 Query: 229 PEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 ++ D T P ++ L+ ML DP KR Sbjct: 243 ----AICDGNFTIP---------DNSRYSQDMHCLIRYMLEPDPDKRPDIYQV 282 >6NT9-A nrPDB Length = 742 Score = 156 bits (394), Expect = 1e-38, Method: Composition-based stats. Identities = 61/231 (26%), Positives = 95/231 (41%), Gaps = 20/231 (8%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDV 69 +G+G V++GRHK TG + A+K S V +RE +LK+L H NIV L + Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPV-DVQMREFEVLKKLNHKNIVKLFAI 73 Query: 70 LMQDS--RLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLH 126 + + LI EF L L+ + S L ++ G+ ++H Sbjct: 74 EEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVH 133 Query: 127 RDLKPQNLL--IDDKGT--IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL------ 176 R++KP N++ I + G KL DFG AR + T Y P++ Sbjct: 134 RNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD-EQFVSLYGTEEYLHPDMYERAVLRK 192 Query: 177 -GSARYSTPVDIWSIGTIFAELATKKPLFH----GDSEIDQLFRIFRALGT 222 +Y VD+WSIG F AT F + +++I + Sbjct: 193 DHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPS 243 >2H34-A nrPDB Length = 309 Score = 155 bits (391), Expect = 3e-38, Method: Composition-based stats. Identities = 55/224 (24%), Positives = 94/224 (41%), Gaps = 7/224 (3%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE-SEEEGVPSTAIREISLLKELRHPN 62 Y +G G G VY+ ++VA+K + S + + RE L+ P+ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 63 IVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 +V + D D +LY+ ++ DL L P + + + QI + H+ Sbjct: 96 VVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGP---LAPPRAVAIVRQIGSALDAAHA 152 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI-RVYTHEVVTLWYRSPEVLLGSAR 180 HRD+KP+N+L+ L DFG+A A + V TL+Y +PE + Sbjct: 153 AGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPER-FSESH 211 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPN 224 + DI+++ + E T P + GD I +A+ P+ Sbjct: 212 ATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPS 255 >5CEK-A nrPDB Length = 263 Score = 151 bits (382), Expect = 4e-37, Method: Composition-based stats. Identities = 46/276 (16%), Positives = 97/276 (35%), Gaps = 42/276 (15%) Query: 18 VYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLY 77 V + TG+ + K ++ ++ + ++ H NI + +V++ +++ Y Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDKIR-------PYIQLPSHSNITGIVEVILGETKAY 77 Query: 78 LIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID 137 + FE D+ Y+ S + + QI+ + CH ++ DLK + + Sbjct: 78 VFFEKDFGDMHSYVRS---RKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFS 134 Query: 138 --DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS-TPVDIWSIGTIF 194 ++ ++L + + Y SPE+L + YS D+WS+G + Sbjct: 135 TEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVML 194 Query: 195 AELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVK 254 L + FH +I R Sbjct: 195 YTLLVGRYPFHDSDPSALFSKIRRGQFCIPEH---------------------------- 226 Query: 255 NLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 + L+ +L +P++R++ L HP+F + Sbjct: 227 -ISPKARCLIRSLLRREPSERLTAPEILLHPWFESV 261 >6DC0-A nrPDB Length = 292 Score = 151 bits (381), Expect = 4e-37, Method: Composition-based stats. Identities = 46/276 (16%), Positives = 97/276 (35%), Gaps = 42/276 (15%) Query: 18 VYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLY 77 V + TG+ + K ++ ++ + ++ H NI + +V++ +++ Y Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDKIR-------PYIQLPSHSNITGIVEVILGETKAY 74 Query: 78 LIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID 137 + FE D+ Y+ S + + QI+ + CH ++ DLK + + Sbjct: 75 VFFEKDFGDMHSYVRS---RKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFS 131 Query: 138 --DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS-TPVDIWSIGTIF 194 ++ ++L + + Y SPE+L + YS D+WS+G + Sbjct: 132 TEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVML 191 Query: 195 AELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVK 254 L + FH +I R Sbjct: 192 YTLLVGRYPFHDSDPSALFSKIRRGQFCIPEH---------------------------- 223 Query: 255 NLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290 + L+ +L +P++R++ L HP+F + Sbjct: 224 -ISPKARCLIRSLLRREPSERLTAPEILLHPWFESV 258 >5E8V-A nrPDB Length = 316 Score = 150 bits (380), Expect = 5e-37, Method: Composition-based stats. Identities = 62/308 (20%), Positives = 116/308 (37%), Gaps = 47/308 (15%) Query: 10 IGEGTYGVVYKGRHKTTG----QVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVS 65 +G+G + VYK + K + VA+K EE ++I L+H NI+ Sbjct: 17 VGKGRFAEVYKAKLKQNTSEQFETVAVKIF---PYEEYASWKTEKDIFSDINLKHENILQ 73 Query: 66 LQDVLMQDSRL----YLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 + + L +LI F + +L++YL + ++ + +GI H Sbjct: 74 FLTAEERKTELGKQYWLITAFHAKGNLQEYLTR----HVISWEDLRKLGSSLARGIAHLH 129 Query: 121 SRR---------VLHRDLKPQNLLIDDKGTIKLADFGLARAFG----IPIRVYTHEVVTL 167 S ++HRDLK N+L+ + T L DFGL+ + + +V T Sbjct: 130 SDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA 189 Query: 168 WYRSPEVLLGSARYS-----TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGT 222 Y +PEVL + D++S+ + E+ ++ + + ++ G+ Sbjct: 190 RYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRC------NAVGEVKDYEPPFGS 243 Query: 223 PNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA- 281 E P V S+ D + + L++ +DP R++ + Sbjct: 244 KVREH-PCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVA 302 Query: 282 -----LNH 284 L H Sbjct: 303 ERFSELEH 310 >6BFN-A nrPDB Length = 342 Score = 150 bits (379), Expect = 7e-37, Method: Composition-based stats. Identities = 60/208 (28%), Positives = 93/208 (44%), Gaps = 18/208 (8%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEG--VPSTAIREISLLKELRHPNIVSL 66 KIGEG +G VY+ + T V A+K+++ ++ E V + + E+ L RHPNIV Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDF 86 Query: 67 QDVLMQDSRLYLIFEFL-SMDLKKYLDSIPPGQY-MDSSLVKSYLYQILQGIVFCH--SR 122 Q+ L++ FL + L+ L + L + I F H S Sbjct: 87 AGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP 146 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARA--------FGIPIRVYTHEV-VTLWYRSPE 173 ++H D+K N+L+D++ T KL DFGLAR + T V TL Y PE Sbjct: 147 SLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYL-PE 205 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKK 201 + + R + D +S G + E + Sbjct: 206 EYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >2QLU-A nrPDB Length = 314 Score = 149 bits (376), Expect = 1e-36, Method: Composition-based stats. Identities = 64/297 (21%), Positives = 110/297 (37%), Gaps = 37/297 (12%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 +E G +G V+K + VA+K L+ ++ REI ++H N+ Sbjct: 17 LQLLEIKARGRFGCVWKAQLMND--FVAVKIFPLQDKQSWQSE---REIFSTPGMKHENL 71 Query: 64 VSLQDVLMQDS----RLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 + + S L+LI F L YL G + + + + +G+ + Sbjct: 72 LQFIAAEKRGSNLEVELWLITAFHDKGSLTDYL----KGNIITWNELCHVAETMSRGLSY 127 Query: 119 CHS-----------RRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTHEVV 165 H + HRD K +N+L+ T LADFGLA F G P +V Sbjct: 128 LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG 187 Query: 166 TLWYRSPEVLLGSARYST----PVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG 221 T Y +PEVL G+ + +D++++G + EL ++ G + L Sbjct: 188 TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ 247 Query: 222 TPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISG 278 P+ E EV + + T + + + +D R+S Sbjct: 248 HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVT------IEECWDHDAEARLSA 298 >5IKW-A nrPDB Length = 310 Score = 147 bits (371), Expect = 6e-36, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 112/295 (37%), Gaps = 53/295 (17%) Query: 5 TKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHPNI 63 T E + EG + V+ R G A+K++ + + + + REI+++KEL H NI Sbjct: 17 TLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPD--LNVCKREITIMKELSGHKNI 73 Query: 64 VSLQDVLMQD--SRLY---LIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 V D + ++ ++ E+ + V + + Sbjct: 74 VGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVAR 133 Query: 119 CHSRR--VLHRDLKPQNLLIDDKGTIKLADFGLA-RAFGIPIRVYTHEV-------VTLW 168 H + ++HRDLK +N+L++D G L DFG A F P + + V TL Sbjct: 134 LHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLS 193 Query: 169 YRSPEV--LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNE 226 YR+PE+ L G +T DIW++G + +L F G+S++ Sbjct: 194 YRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-GESQV---------------- 236 Query: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 ++ D T P S H L+ ML DP R Sbjct: 237 ------AICDGNFTIPDNSRYSRNIHC---------LIRFMLEPDPEHRPDIFQV 276 >5VC6-A nrPDB Length = 289 Score = 147 bits (371), Expect = 7e-36, Method: Composition-based stats. Identities = 56/304 (18%), Positives = 109/304 (35%), Gaps = 57/304 (18%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHP 61 ++ ++EKIG G +G V+K + G + A+K+ + A+RE+ L +H Sbjct: 12 EFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHS 71 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMD-LKKYL-DSIPPGQYMDSSLVKSYLYQILQGIVFC 119 ++V +D + + E+ + L + ++ Y + +K L Q+ +G+ + Sbjct: 72 HVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYI 131 Query: 120 HSRRVLHRDLKPQNLLIDDKGTI-------------------KLADFGLARAFGIPIRVY 160 HS ++H D+KP N+ I K+ D G P Sbjct: 132 HSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEE 191 Query: 161 THEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRAL 220 + + EVL + + DI+++ A +PL + ++ + Sbjct: 192 GDS----RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQ----- 242 Query: 221 GTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKM 280 G L + L + +LL M+ DP +R S Sbjct: 243 --------------------------GRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMA 276 Query: 281 ALNH 284 + H Sbjct: 277 LVKH 280 >3HNG-A nrPDB Length = 360 Score = 146 bits (370), Expect = 9e-36, Method: Composition-based stats. Identities = 63/341 (18%), Positives = 116/341 (34%), Gaps = 85/341 (24%) Query: 2 EDYTKIEKIGEGTYGVVYKG-----RHKTTGQVVAMKKIRLESEEEGVPSTAIREIS--- 53 E + +G G +G V + + T + VA+K ++ E + E+ Sbjct: 27 ERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLK-EGATASEYKALMTELKILT 85 Query: 54 ------------------------LLKELRHPNIVSLQ----DVLMQDSRLYLIFEF--- 82 +++ ++ N+ + D+ + L E Sbjct: 86 HIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKE 145 Query: 83 -LSMDLKK----YLDSIPPGQYM----------------------------DSSLVKSYL 109 + L++ LDS+ + + SY Sbjct: 146 KMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYS 205 Query: 110 YQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVYTHEVVTL 167 +Q+ +G+ F SR+ +HRDL +N+L+ + +K+ DFGLAR + L Sbjct: 206 FQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPL 265 Query: 168 WYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHG---DSEIDQLFRIFRALGTP 223 + +PE + YST D+WS G + E+ + + G D + R + P Sbjct: 266 KWMAPESIFDKI-YSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAP 324 Query: 224 NNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLL 264 + + D + PK +P L E DLL Sbjct: 325 EYSTPEIYQIMLDCWHRDPKERPR-----FAELVEKLGDLL 360 >4M66-A nrPDB Length = 325 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 56/215 (26%), Positives = 96/215 (44%), Gaps = 26/215 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 E+ K+E +G+G +GVV++ H+T VA+K + + E+ + LR+ Sbjct: 20 EELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKIS--------WEVKAMVNLRNE 71 Query: 62 NIVSLQDVLMQDSRLY-----LIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 N++ L V + L+ F+ + L L P L+ L +++ G Sbjct: 72 NVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPR---PWPLLCRLLQEVVLG 128 Query: 116 IVFCHSRR--VLHRDLKPQNLLIDDKGTIKLADFGLAR------AFGIPIRVYTHEVVTL 167 + + HS +LHRDLKP N+L+D + KLADFGL+ + TL Sbjct: 129 MCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTL 188 Query: 168 WYRSPEVLLG-SARYSTPVDIWSIGTIFAELATKK 201 Y PE+L + + S D++S G + + + Sbjct: 189 AYLDPELLFKVNLKASKASDVYSFGILVWAVLAGR 223 >3QD2-B nrPDB Length = 332 Score = 144 bits (365), Expect = 3e-35, Method: Composition-based stats. Identities = 67/315 (21%), Positives = 108/315 (34%), Gaps = 70/315 (22%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEE------------------- 41 + D+ I+ +G G +GVV++ ++K A+K+IRL + E Sbjct: 5 LTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHP 64 Query: 42 ----------EGVPSTAIRE---------------------------ISLLKELRHPNIV 64 E P E I + N V Sbjct: 65 GIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTV 124 Query: 65 SLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 LY+ + +LK +++ + + + QI + + F HS+ Sbjct: 125 GQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKG 184 Query: 124 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR------------VYTHEVVTLWYRS 171 ++HRDLKP N+ +K+ DFGL A +T +V T Y S Sbjct: 185 LMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMS 244 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEV 231 PE + G+ YS VDI+S+G I EL I R + + E Sbjct: 245 PEQIHGN-NYSHKVDIFSLGLILFELLYSFSTQMERVRIITDVRNLKFPLLFTQKYPQEH 303 Query: 232 ESLQDYKNTFPKWKP 246 +QD + P +P Sbjct: 304 MMVQDMLSPSPTERP 318 >5VDK-A nrPDB Length = 297 Score = 144 bits (363), Expect = 5e-35, Method: Composition-based stats. Identities = 60/304 (19%), Positives = 111/304 (36%), Gaps = 61/304 (20%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RH 60 +++ ++EKIG G +G VYK + G V A+K+ E ++A+ E+ L H Sbjct: 15 KEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHH 74 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKK--YLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 P++V +D + + E+ + + ++ G + + +K L QI G+ + Sbjct: 75 PHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNY 134 Query: 119 CHSRRVLHRDLKPQNLLIDDKGT-----------------------IKLADFGLARAFGI 155 H+ ++H D+KP N+ I K K+ D G A + Sbjct: 135 IHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINK 194 Query: 156 PIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFR 215 P E + + E+L R+ DI+++G A A + L + + + Sbjct: 195 P----KVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHHIRK 250 Query: 216 IFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKR 275 G+ + L E+ LL M+ D +R Sbjct: 251 -------------------------------GNFPDVPQELSESFSSLLKNMIQPDAEQR 279 Query: 276 ISGK 279 S Sbjct: 280 PSAA 283 >5L2Q-C nrPDB Length = 320 Score = 141 bits (356), Expect = 4e-34, Method: Composition-based stats. Identities = 58/302 (19%), Positives = 109/302 (36%), Gaps = 64/302 (21%) Query: 19 YKGRHKTTGQVVAMKKIRLESE-EEGVPSTAIR--------EISLLKELR-HPNIVSLQD 68 R T +K + LE ++G+ S R E SLL L +V Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 69 VLMQ------------------DSRLYLIFEFLSM--------DLKKYLDSIPPGQYMDS 102 + R+ L+ + L DL + + + Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 103 SLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGT-IKLADFGLARAFGIPIRVYT 161 Y +++ + H + ++HRDLK N++++ + I + +F L + + Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 162 HEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG 221 + + Y SP+VL G P D+W++G + + + F+ DS +LFR +A Sbjct: 213 DQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFY-DSIPQELFRKIKA-- 269 Query: 222 TPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 + T P+ + EN + L+ K+L+ DP +R++ Sbjct: 270 ---------------AEYTIPE---------DGRVSENTVCLIRKLLVLDPQQRLAAADV 305 Query: 282 LN 283 L Sbjct: 306 LE 307 >4L00-A nrPDB Length = 304 Score = 137 bits (346), Expect = 4e-33, Method: Composition-based stats. Identities = 55/311 (17%), Positives = 110/311 (35%), Gaps = 58/311 (18%) Query: 2 EDYTKIEKIGEGTYGVVYKGR------HKTTGQVVAMKKIRL--ESEEEGVPSTAIREIS 53 +D + E +G GT +Y G + T + +K I + + S Sbjct: 25 KDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAAS 84 Query: 54 LLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQIL 113 +++++ H +IV L V ++D ++ EF+ + + Q+ Sbjct: 85 MMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMH-RKSDVLTTPWKFKVAKQLA 143 Query: 114 QGIVFCHSRRVLHRDLKPQNLLIDDKGT-------IKLADFGLARAFGIPIRVYTHEVVT 166 + + + ++H ++ +NLL+ +G IKL+D G I + + Sbjct: 144 SALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPG----IPITVLSRQECIER 199 Query: 167 LWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNE 226 + + +PE + S S D WS GT E+ + D + + R + + P Sbjct: 200 IPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTP 259 Query: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286 E+ DL+++ + YDP +R P+ Sbjct: 260 SCKELA-----------------------------DLMTRCMNYDPNQR---------PF 281 Query: 287 FNDLDNQIKKM 297 F + I K+ Sbjct: 282 FRAIMRDINKL 292 >3SV0-A nrPDB Length = 483 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 51/220 (23%), Positives = 91/220 (41%), Gaps = 26/220 (11%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + KIG G++G +Y G + T + VA+K LE+ + P + E + + L+ Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK---LENVKTKHPQ-LLYESKIYRILQGG 62 Query: 62 -NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 I +++ ++ L+ + L L+ + + V Q++ + F H Sbjct: 63 TGIPNVRWFGVEGDYNVLVMDLLGPSLEDLFNFCSRK--LSLKTVLMLADQMINRVEFVH 120 Query: 121 SRRVLHRDLKPQNLLID---DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 S+ LHRD+KP N L+ + + DFGLA+ + T + YR + L G Sbjct: 121 SKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRD-----TSTHQHIPYRENKNLTG 175 Query: 178 SARY-----------STPVDIWSIGTIFAELATKKPLFHG 206 +ARY S D+ S+G + + G Sbjct: 176 TARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQG 215 >4M69-B nrPDB Length = 283 Score = 133 bits (335), Expect = 9e-32, Method: Composition-based stats. Identities = 53/280 (18%), Positives = 101/280 (36%), Gaps = 44/280 (15%) Query: 16 GVVYKGRHKTTGQVVAMKKIRLESEEE--GVPSTAIREISLLKELRHPNIVSLQDVLMQ- 72 +Y+G + + V +K E V T EI +K+ PNI+ + + + Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 80 Query: 73 ---DSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 ++ E+ L++ LD + S+ + + +G+ H LHR+ Sbjct: 81 TVKPPEFSIVMEYCELGTLRELLDREKD---LTMSVRSLLVLRAARGLYRLHHSETLHRN 137 Query: 129 LKPQNLLIDDKGTIKLADFGLARAFGIPIRV----YTHEVVTLWYRSPEVLLGS-ARYST 183 + + L+ +KLA F L++ R + Y SPE L Y Sbjct: 138 ISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDI 197 Query: 184 PVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPK 243 +I+S G + E+AT K F G + R L + + P + Sbjct: 198 KAEIYSFGIVLWEIATGKIPFEGCDS-----KKIRELVAEDKKQEPVGQ----------- 241 Query: 244 WKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 + E +++++ ++P++R S L Sbjct: 242 -----------DCPELLREIINECRAHEPSQRPSVDGILE 270 >5X1R-A nrPDB Length = 302 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 47/225 (20%), Positives = 85/225 (37%), Gaps = 22/225 (9%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKI-------------------RLESEE 41 ++ E IGEG +G+VY+ + +A+K+ R Sbjct: 20 FNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTF 79 Query: 42 EGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMD 101 + ++ I+E LL HP ++ + ++ Y+ +F S K L + P + +D Sbjct: 80 QAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQP-EKID 138 Query: 102 SSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYT 161 + ++ L + I H LHRD+ N+ I + L DFG AR + T Sbjct: 139 EAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDET 198 Query: 162 HEVVTLWYRSPEVLLGS--ARYSTPVDIWSIGTIFAELATKKPLF 204 V+ + E + DI+++G + L P Sbjct: 199 EIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPPP 243 >4BTK-A nrPDB Length = 337 Score = 133 bits (334), Expect = 1e-31, Method: Composition-based stats. Identities = 51/228 (22%), Positives = 86/228 (37%), Gaps = 17/228 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + + ++KIG G +G +Y+ T + VA+K + E+++LK+L+ Sbjct: 56 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV----ESAQQPKQVLKMEVAVLKKLQGK 111 Query: 62 -NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 ++ + Y++ + +L L P S QIL+ I H Sbjct: 112 DHVCRFIGCGRNEKFNYVVMQLQGRNLAD-LRRSQPRGTFTLSTTLRLGKQILESIEAIH 170 Query: 121 SRRVLHRDLKPQNL----LIDDKGTIKLADFGLARAFGI------PIRVYTHEVVTLWYR 170 S LHRD+KP N L + DFGLAR + P R T+ Y Sbjct: 171 SVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYA 230 Query: 171 SPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 218 S D+WS+ + E A + + + +Q+ I Sbjct: 231 SVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 277 >4BTF-A nrPDB Length = 469 Score = 132 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 53/280 (18%), Positives = 101/280 (36%), Gaps = 44/280 (15%) Query: 16 GVVYKGRHKTTGQVVAMKKIRLESEEE--GVPSTAIREISLLKELRHPNIVSLQDVLMQ- 72 +Y+G + + V +K E V T EI +K+ PNI+ + + + Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQ 266 Query: 73 ---DSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 ++ E+ L++ LD + S+ + + +G+ H LHR+ Sbjct: 267 TVKPPEFSIVMEYCELGTLRELLDREKD---LTMSVRSLLVLRAARGLYRLHHSETLHRN 323 Query: 129 LKPQNLLIDDKGTIKLADFGLARAFGIPIRV----YTHEVVTLWYRSPEVLLGS-ARYST 183 + + L+ +KLA F L++ R + Y SPE L Y Sbjct: 324 ISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDI 383 Query: 184 PVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPK 243 +I+S G + E+AT K F G + R L + + P + Sbjct: 384 KAEIYSFGIVLWEIATGKIPFEGCDS-----KKIRELVAEDKKQEPVGQ----------- 427 Query: 244 WKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 + E +++++ ++P++R S L Sbjct: 428 -----------DCPELLREIINECRAHEPSQRPSVDGILE 456 >4NFN-A nrPDB Length = 309 Score = 131 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 51/228 (22%), Positives = 86/228 (37%), Gaps = 17/228 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + + ++KIG G +G +Y+ T + VA+K + E+++LK+L+ Sbjct: 21 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV----ESAQQPKQVLKMEVAVLKKLQGK 76 Query: 62 -NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 ++ + Y++ + +L L P S QIL+ I H Sbjct: 77 DHVCRFIGCGRNEKFNYVVMQLQGRNLAD-LRRSQPRGTFTLSTTLRLGKQILESIEAIH 135 Query: 121 SRRVLHRDLKPQNL----LIDDKGTIKLADFGLARAFGI------PIRVYTHEVVTLWYR 170 S LHRD+KP N L + DFGLAR + P R T+ Y Sbjct: 136 SVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYA 195 Query: 171 SPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 218 S D+WS+ + E A + + + +Q+ I Sbjct: 196 SVNAHKNREM-GRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 242 >5FQD-C nrPDB Length = 341 Score = 131 bits (329), Expect = 4e-31, Method: Composition-based stats. Identities = 53/205 (25%), Positives = 86/205 (41%), Gaps = 19/205 (9%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP- 61 Y + KIG G++G +Y + T G+ VA+K LES++ P + E L K L+ Sbjct: 20 KYKLVRKIGSGSFGDIYLAINITNGEEVAVK---LESQKARHPQ-LLYESKLYKILQGGV 75 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 I ++ + L+ + L L+ + V Q++ I + H+ Sbjct: 76 GIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSR--RFTMKTVLMLADQMISRIEYVHT 133 Query: 122 RRVLHRDLKPQNLLIDDKGTI---KLADFGLARAF-------GIPIRVYTHEVVTLWYRS 171 + +HRD+KP N L+ L DFGLA+ + IP R + T Y S Sbjct: 134 KNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYAS 193 Query: 172 PEVLLGSARYSTPVDIWSIG-TIFA 195 LG + S D+ S+G + Sbjct: 194 INAHLGIEQ-SRRDDMESLGYVLMY 217 >5J0A-A nrPDB Length = 300 Score = 131 bits (329), Expect = 4e-31, Method: Composition-based stats. Identities = 58/299 (19%), Positives = 108/299 (36%), Gaps = 34/299 (11%) Query: 6 KIEKIGEGTYGV---VYKGRHKTTGQ---VVAMKKIRLESEEEG---VPSTAIREISLLK 56 ++K+G +G VY + G A+KKI + + E +LK Sbjct: 13 FMQKLG---FGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILK 69 Query: 57 ELRHPNIVSLQDVLM-QDSRLYLIFEFLS-MDLKKYLDSIPPGQY--MDSSLVKSYLYQI 112 L HPNIV + D L L E+ L ++ ++++ + Sbjct: 70 SLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNM 129 Query: 113 LQGIVFCHS-RRVLHRDLKPQNLLIDDKG-TIKLADFGLARAFGIPIRVYTHE---VVTL 167 +G+ + H +++LH D+K N++I TIK+ D G++ + V E + T Sbjct: 130 ARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTE 189 Query: 168 WYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEV 227 ++ E + + + DI++ G E+ T S D ++ Sbjct: 190 PWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDD----------DDEDKT 239 Query: 228 WPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGK---MALN 283 + E + + +P + + ++L S DP R S AL Sbjct: 240 FDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALE 298 >4RT7-A nrPDB Length = 415 Score = 129 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 40/205 (19%), Positives = 79/205 (38%), Gaps = 17/205 (8%) Query: 50 REISLLKELRHPNIVSLQD-VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSY 108 RE+ + I L + + E+ + +K L+ + + + Sbjct: 198 REVQIHP--DSDQISGLHGNSFHSEDEI----EYEN---QKRLEEEEDLNVLTFEDLLCF 248 Query: 109 LYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIR--VYTHEVVT 166 YQ+ +G+ F + +HRDL +N+L+ +K+ DFGLAR V + + Sbjct: 249 AYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLP 308 Query: 167 LWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHG---DSEIDQLFRIFRALGT 222 + + +PE L Y+ D+WS G + E+ + + G D+ +L + + Sbjct: 309 VKWMAPESLF-EGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQ 367 Query: 223 PNNEVWPEVESLQDYKNTFPKWKPG 247 P +Q + +P Sbjct: 368 PFYATEEIYIIMQSCWAFDSRKRPS 392 Score = 83.0 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 26/111 (23%), Positives = 46/111 (41%), Gaps = 8/111 (7%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQ-----VVAMKKIRLESEEEGVPSTAIREISLLK 56 E+ + +G G +G V + VA+K ++ E + + E+ ++ Sbjct: 65 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK-EKADSSEREALMSELKMMT 123 Query: 57 ELR-HPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLV 105 +L H NIV+L +YLIFE+ DL YL S + + + Sbjct: 124 QLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEI 174 >4TN6-A nrPDB Length = 318 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 61/284 (21%), Positives = 107/284 (37%), Gaps = 30/284 (10%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 Y KIG G++G +Y G G+ VA+K LE + P I E + K ++ Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK---LECVKTKHPQLHI-ESKIYKMMQGG 62 Query: 62 -NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 I +++ + ++ E L L+ + V Q++ I + H Sbjct: 63 VGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRK--FSLKTVLLLADQMISRIEYIH 120 Query: 121 SRRVLHRDLKPQNLLI---DDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 S+ +HRD+KP N L+ + + DFGLA+ + TH+ + YR + L G Sbjct: 121 SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRD---ARTHQ--HIPYRENKNLTG 175 Query: 178 SARY-----------STPVDIWSIGTIFAELATKKPLFHG---DSEIDQLFRI-FRALGT 222 +ARY S D+ S+G + + G ++ + RI + + T Sbjct: 176 TARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMST 235 Query: 223 PNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSK 266 P + S F + L + +L + Sbjct: 236 PIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHR 279 >2CHL-A nrPDB Length = 351 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 59/281 (20%), Positives = 104/281 (37%), Gaps = 25/281 (8%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH-P 61 ++ +KIG G +G + G++ T + VA+K LE + P + E K+L Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPMKSRAPQLHL-EYRFYKQLGSGD 86 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 I + ++ E L L+ D V Q++ + + HS Sbjct: 87 GIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDR--TFSLKTVLMIAIQLISRMEYVHS 144 Query: 122 RRVLHRDLKPQNLLIDDKGT-----IKLADFGLARAF-------GIPIRVYTHEVVTLWY 169 + +++RD+KP+N LI G I + DF LA+ + IP R + T Y Sbjct: 145 KNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARY 204 Query: 170 RSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHG---DSEIDQLFRIFR-ALGTPNN 225 S LG + S D+ ++G +F + G D+ ++ +I TP Sbjct: 205 MSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIE 263 Query: 226 EVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSK 266 + + Y + L + DL + Sbjct: 264 VLCENFPEMATYLRYVRRLDFFE-KPDYDYLRKLFTDLFDR 303 >4MWI-A nrPDB Length = 294 Score = 127 bits (320), Expect = 5e-30, Method: Composition-based stats. Identities = 51/279 (18%), Positives = 98/279 (35%), Gaps = 46/279 (16%) Query: 19 YKGRHKTTGQVVAMKKIRLESEEEG--VPSTAIREISLLKELRHPNIVSLQDVLMQDS-- 74 YKG + VA+K + V T +EI +K+ PNI+ + + + ++ Sbjct: 41 YKGEYHR--APVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVT 98 Query: 75 --RLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRV--LHRDL 129 + ++ E+ L++ LD + + +G+ H LH + Sbjct: 99 PPQFSIVMEYCELGTLRELLDREKD---LTLGKRMVLVLGAARGLYRLHHSEAPELHGKI 155 Query: 130 KPQNLLIDDKGTIKLADFGLARAFGI----PIRVYTHEVVTLWYRSP-EVLLGSARYSTP 184 + N L+ +KLA F L + R T V + Y SP E+ +Y Sbjct: 156 RSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVK 215 Query: 185 VDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKW 244 +I+S G + E+AT F G + +I + + + Sbjct: 216 SEIYSFGIVLWEIATGDIPFQGCNS----EKIRKLVAVKRQQ------------------ 253 Query: 245 KPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 ++ +++ + +DP+ R S L Sbjct: 254 -----EPLGEDCPSELREIIDECRAHDPSVRPSVDEILK 287 >4JRN-A nrPDB Length = 372 Score = 126 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 61/321 (19%), Positives = 104/321 (32%), Gaps = 74/321 (23%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPS-TAIREISLLKEL-------RHP 61 +G G + VY+ T + +A+K E E RE S + Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQ 135 Query: 62 NIVSLQ---DVLMQDS-----------------RLYLIFEFLSMDLKKYL-----DSIPP 96 DV+M + +L+ D+ K + D+ Sbjct: 136 ESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASVN 195 Query: 97 GQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP 156 + Q ++ + ++ ++H D+KP N L+ G + L DFG R Sbjct: 196 KSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRINNSV 255 Query: 157 IRVYTHEVVTLWYRSPEVLLGSA--RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLF 214 R + T Y PE + Y+ P D W +G + K+ Sbjct: 256 GRA----IGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERP----------- 300 Query: 215 RIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAK 274 TP + +W DY + + + E DL+ +L DP K Sbjct: 301 -------TPADGIW-------DYLH----------FADCPSTPELVQDLIRSLLNRDPQK 336 Query: 275 RISGKMALNHPYFNDLDNQIK 295 R+ AL F ++D+ +K Sbjct: 337 RMLPLQALETAAFKEMDSVVK 357 >2CMW-A nrPDB Length = 310 Score = 126 bits (316), Expect = 1e-29, Method: Composition-based stats. Identities = 60/279 (21%), Positives = 103/279 (36%), Gaps = 25/279 (8%) Query: 6 KIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH--PNI 63 +KIG G +G + G++ T + VA+K LE + P + E K+L + Sbjct: 4 VGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPIKSRAPQLHL-EYRFYKQLGSAGEGL 59 Query: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123 + ++ E L L+ D V Q+L + + HS+ Sbjct: 60 PQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDR--TFTLKTVLMIAIQLLSRMEYVHSKN 117 Query: 124 VLHRDLKPQNLLIDDKGT-----IKLADFGLARAF-------GIPIRVYTHEVVTLWYRS 171 +++RD+KP+N LI +G I + DFGLA+ + IP R + T Y S Sbjct: 118 LIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMS 177 Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHG---DSEIDQLFRIF-RALGTPNNEV 227 LG + S D+ ++G +F + G D+ ++ +I TP + Sbjct: 178 INTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEAL 236 Query: 228 WPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSK 266 + + + L DL K Sbjct: 237 CENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEK 275 >2C47-A nrPDB Length = 313 Score = 125 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 61/282 (21%), Positives = 108/282 (38%), Gaps = 28/282 (9%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH-P 61 ++ +KIG G +G + G++ T + VA+K LE + P + E K+L Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPIKSRAPQLHL-EYRFYKQLSATE 60 Query: 62 NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 + + ++ E L L+ D V Q++ + + H+ Sbjct: 61 GVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDR--TFTLKTVLMIAIQLITRMEYVHT 118 Query: 122 RRVLHRDLKPQNLLIDDKGT-----IKLADFGLARAF-------GIPIRVYTHEVVTLWY 169 + +++RD+KP+N L+ GT I + DFGLA+ + IP R + T Y Sbjct: 119 KSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY 178 Query: 170 RSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 S LG + S D+ ++G +F + G D L ++ +G Sbjct: 179 MSINTHLGKEQ-SRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDTKRATPI 236 Query: 230 EVESLQDYKNTFPKWKPGSL--ASHVKNLDENGLDLLSKMLI 269 EV FP+ L + ++ D L K+ Sbjct: 237 EVLC-----ENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFT 273 >5USZ-A nrPDB Length = 289 Score = 124 bits (313), Expect = 3e-29, Method: Composition-based stats. Identities = 53/292 (18%), Positives = 103/292 (35%), Gaps = 53/292 (18%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQ-------VVAMKKIRLESEEEGVPSTAIREISL 54 ED E +G+GT+ ++KG + G V +K + + + S+ Sbjct: 8 EDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVL--DKAHRNYSESFFEAASM 65 Query: 55 LKELRHPNIVSLQDVLMQDSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQIL 113 + +L H ++V V + L+ EF+ L YL ++ Q+ Sbjct: 66 MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKK--NKNCINILWKLEVAKQLA 123 Query: 114 QGIVFCHSRRVLHRDLKPQNLLI--------DDKGTIKLADFGLARAFGIPIRVYTHEVV 165 + F ++H ++ +N+L+ + IKL+D G++ +P + Sbjct: 124 AAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITV-LPKDILQER-- 180 Query: 166 TLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNN 225 + + PE + + D WS GT E+ + GD + L Sbjct: 181 -IPWVPPECIENPKNLNLATDKWSFGTTLWEICSG-----GDKPLSAL------------ 222 Query: 226 EVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS 277 + ++ P K LA+ L++ + Y+P R S Sbjct: 223 -DSQRKLQFYEDRHQLPAPKAAELAN-----------LINNCMDYEPDHRPS 262 >5X18-A nrPDB Length = 295 Score = 124 bits (313), Expect = 3e-29, Method: Composition-based stats. Identities = 59/237 (24%), Positives = 93/237 (39%), Gaps = 23/237 (9%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH-PN 62 Y +KIGEG++GV+++G + G VA+K E + P E K L PN Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIK---FEPRKTEAPQ-LRDEYKTYKILNGTPN 64 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 I + L+ + L L+ D G+ V Q++ I H+ Sbjct: 65 IPYAYYFGQEGLHNILVIDLLGPSLEDLFDWC--GRKFSVKTVVQVAVQMITLIEDLHAH 122 Query: 123 RVLHRDLKPQNLLIDDKGT-----IKLADFGLARAF-------GIPIRVYTHEVVTLWYR 170 +++RD+KP N LI G I L DFG+A+ + IP R T Y Sbjct: 123 DLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARYM 182 Query: 171 SPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHG---DSEIDQLFRIFRALGTPN 224 S LG + S D+ ++G +F + G + + +I + N Sbjct: 183 SINTHLGREQ-SRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEKKRSTN 238 >4I94-A nrPDB Length = 300 Score = 123 bits (309), Expect = 9e-29, Method: Composition-based stats. Identities = 60/279 (21%), Positives = 107/279 (38%), Gaps = 40/279 (14%) Query: 6 KIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVS 65 + + GE VVYKG+ + +A+K+ +S + + E + +LR+ + + Sbjct: 33 IVSEHGERAPNVVYKGKL-ENQRRIAVKRFNRKSWPDS--RQFLEEAKAVGQLRNHRMAN 89 Query: 66 LQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR- 123 L +D LI EF+ + L K+L Q M ++ I Q + +C S+ Sbjct: 90 LLGCCYEDEERLLIAEFMPNETLAKHLFHW-ESQPMKWAMRLRVALHIAQALEYCTSKGR 148 Query: 124 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYST 183 L+ DL +L DD +L+ FGL + T+ T PE L + R + Sbjct: 149 ALYHDLNAYRVLFDDDANPRLSCFGLMKNSRDGKSYSTNLAFTP----PEYLR-TGRVTP 203 Query: 184 PVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPK 243 I+S GT+ +L + K + + R + L E Sbjct: 204 ESVIYSFGTLLLDLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFS------------- 250 Query: 244 WKPGSLASHVKNLDENGLDLLS---KMLIYDPAKRISGK 279 ++G +L+ + L Y+P +R + K Sbjct: 251 -------------SDDGTELIRLASRCLQYEPRERPNPK 276 >2PZI-A nrPDB Length = 681 Score = 121 bits (303), Expect = 5e-28, Method: Composition-based stats. Identities = 60/286 (20%), Positives = 113/286 (39%), Gaps = 53/286 (18%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKT-TGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 Y I G G +Y + G+ V +K + + S + + A+ E L E+ HP Sbjct: 81 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGL-VHSGDAEAQAMAMAERQFLAEVVHP 139 Query: 62 NIVSLQDVLMQDSRL-----YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 +IV + + + R Y++ E++ K GQ + + +YL +IL + Sbjct: 140 SIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLK----RSKGQKLPVAEAIAYLLEILPAL 195 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 + HS +++ DLKP+N+++ ++ +KL D G +Y T +++PE++ Sbjct: 196 SYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPGFQAPEIVR 250 Query: 177 GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 236 + DI+++G A L P +G Sbjct: 251 TGP--TVATDIYTVGRTLAALTLDLPTRNG-----------------------------R 279 Query: 237 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMAL 282 Y + P+ P +K D G LL + + DP +R + + Sbjct: 280 YVDGLPEDDP-----VLKTYDSYGR-LLRRAIDPDPRQRFTTAEEM 319 >4Y12-A nrPDB Length = 375 Score = 120 bits (302), Expect = 6e-28, Method: Composition-based stats. Identities = 60/286 (20%), Positives = 113/286 (39%), Gaps = 53/286 (18%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKT-TGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 Y I G G +Y + G+ V +K + + S + + A+ E L E+ HP Sbjct: 120 QYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGL-VHSGDAEAQAMAMAERQFLAEVVHP 178 Query: 62 NIVSLQDVLMQDSRL-----YLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGI 116 +IV + + + R Y++ E++ K GQ + + +YL +IL + Sbjct: 179 SIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLK----RSKGQKLPVAEAIAYLLEILPAL 234 Query: 117 VFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176 + HS +++ DLKP+N+++ ++ +KL D G +Y T +++PE++ Sbjct: 235 SYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTPGFQAPEIVR 289 Query: 177 GSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQD 236 + DI+++G A L P +G Sbjct: 290 TGP--TVATDIYTVGRTLAALTLDLPTRNG-----------------------------R 318 Query: 237 YKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMAL 282 Y + P+ P +K D G LL + + DP +R + + Sbjct: 319 YVDGLPEDDP-----VLKTYDSYGR-LLRRAIDPDPRQRFTTAEEM 358 >4NT4-A nrPDB Length = 312 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 60/286 (20%), Positives = 105/286 (36%), Gaps = 30/286 (10%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP- 61 ++ +KIG G +G + G++ + VA+K E + P + E K L Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKM---EPMKSKAPQLHL-EYRFYKLLGSHA 68 Query: 62 -----NIVSLQDVLMQDSRLY-LIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 I + + R ++ E L + L+ + + V Q+L Sbjct: 69 DNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNIC--ARKFSLKTVLMIAKQLLHR 126 Query: 116 IVFCHSRRVLHRDLKPQNLLIDDKGT-----IKLADFGLARAF-------GIPIRVYTHE 163 I + HSR +++RD+KP+N LI T I + DFGLA+ + IP R + Sbjct: 127 IEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSL 186 Query: 164 VVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTP 223 T Y S +G + S D+ ++G +F + G D L ++ +G Sbjct: 187 TGTARYMSINTHMGREQ-SRRDDLEALGHMFMYFLRGSLPWQGLK-ADTLKERYQKIGDT 244 Query: 224 NNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLI 269 EV + + + D D L ++ Sbjct: 245 KRATPIEVLCDGHPEEFATYLRYVRRLDFFETPD---YDFLRRLFQ 287 >5M07-A nrPDB Length = 276 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 44/206 (21%), Positives = 81/206 (39%), Gaps = 22/206 (10%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE-SEEEGVPSTAIREISLLKELRHPN 62 YT + +G G VY +H A+K + + ++ RE + L HP+ Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPH 91 Query: 63 IVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 I+ + D D +L++ +++ D +++ P + V + + + + + H Sbjct: 92 ILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPA-VLPVGEVLAIVTAVAGALDYAHQ 150 Query: 122 RRVLHRDLKPQNLLIDD----KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLG 177 R +LHRD+ P N+++ I LADFG+A Y +PE L Sbjct: 151 RGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ--------------PSYPAPE-LSA 195 Query: 178 SARYSTPVDIWSIGTIFAELATKKPL 203 A D +++ L P Sbjct: 196 GADVDGRADQYALALTAIHLFAGAPP 221 >1CSN-A nrPDB Length = 298 Score = 114 bits (287), Expect = 3e-26, Method: Composition-based stats. Identities = 52/216 (24%), Positives = 86/216 (39%), Gaps = 20/216 (9%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKEL-RHPN 62 Y +IGEG++GV+++G + Q VA+K E P E K L Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIK---FEPRRSDAPQ-LRDEYRTYKLLAGCTG 67 Query: 63 IVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 I ++ + L+ + L L+ LD G+ V Q+L + H + Sbjct: 68 IPNVYYFGQEGLHNVLVIDLLGPSLEDLLDLC--GRKFSVKTVAMAAKQMLARVQSIHEK 125 Query: 123 RVLHRDLKPQNLLI-----DDKGTIKLADFGLARAF-------GIPIRVYTHEVVTLWYR 170 +++RD+KP N LI + I + DFG+ + + IP R + T Y Sbjct: 126 SLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYM 185 Query: 171 SPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHG 206 S LG + S D+ ++G +F + G Sbjct: 186 SINTHLGREQ-SRRDDLEALGHVFMYFLRGSLPWQG 220 >4XHH-A nrPDB Length = 403 Score = 114 bits (286), Expect = 5e-26, Method: Composition-based stats. Identities = 57/284 (20%), Positives = 101/284 (35%), Gaps = 30/284 (10%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 + KIG G++G +Y G + +G+ VA IRLES P E + K L Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVA---IRLESIRSRHPQ-LDYESRVYKYLSGGV 63 Query: 63 IVSLQDVLMQDSRLY-LIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 + ++ ++ + L L+ + V Q++ + + H Sbjct: 64 GIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRK--FSFKTVIMLALQMICRVQYIHG 121 Query: 122 RRVLHRDLKPQNLLID---DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 R +HRD+KP N L+ T+ + DFGL++ + + YR + L G+ Sbjct: 122 RSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRH-----IPYRENKSLTGT 176 Query: 179 ARY-----------STPVDIWSIGTIFAELATKKPLFHG---DSEIDQLFRIFRALGTPN 224 ARY S D+ S+G + + G ++ + RI + Sbjct: 177 ARYASVNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCIS 236 Query: 225 NEVWPEVESLQDYKN-TFPKWKPGSLASHVKNLDENGLDLLSKM 267 E L+ + + + L DL K+ Sbjct: 237 VETLCAGLPLEFSEYMNYCRNLKFDERPDYLYLARLFKDLSIKL 280 >4XHL-A nrPDB Length = 394 Score = 113 bits (284), Expect = 7e-26, Method: Composition-based stats. Identities = 58/284 (20%), Positives = 100/284 (35%), Gaps = 30/284 (10%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 + KIG G++G +Y G + +G+ VA IRLES P E + + L Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVA---IRLESIRSRHPQ-LDYESRVYRYLSGGV 63 Query: 63 IVSLQDVLMQDSRLY-LIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 + ++ ++ + L L+ + V Q+ I + H Sbjct: 64 GIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHR--RFSFKTVIMLALQMFCRIQYIHG 121 Query: 122 RRVLHRDLKPQNLLID---DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 R +HRD+KP N L+ T+ + DFGL++ + + YR + L G+ Sbjct: 122 RSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRH-----IPYRENKSLTGT 176 Query: 179 ARY-----------STPVDIWSIGTIFAELATKKPLFHG---DSEIDQLFRIFRALGTPN 224 ARY S D+ S+G + + G ++ + RI + Sbjct: 177 ARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNVS 236 Query: 225 NEVWPEVESLQDYKN-TFPKWKPGSLASHVKNLDENGLDLLSKM 267 E L+ + + K L DL K+ Sbjct: 237 VETLCSGLPLEFQEYMAYCKNLKFDEKPDYLFLARLFKDLSIKL 280 >5C01-A nrPDB Length = 342 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 56/316 (17%), Positives = 112/316 (35%), Gaps = 72/316 (22%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTG------------------------QVVAMKKIRL 37 ++ T++ +G+GT VY+GR + G V +K + Sbjct: 58 KEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVL-- 115 Query: 38 ESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPP 96 + + SL+ ++ H ++ + V ++ ++ E++ L +L Sbjct: 116 DPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERG 175 Query: 97 GQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGT-------IKLADFGL 149 M +V Q+ + + ++ ++H ++ +N+L+ G IKL+D G+ Sbjct: 176 HVPMAWKMV--VAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGV 233 Query: 150 ARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR-YSTPVDIWSIGTIFAELAT-KKPLFHGD 207 G+ V + + +PE L G A ST +D W G E+ + Sbjct: 234 ----GLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSR 289 Query: 208 SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKM 267 S + E ++ P+ LA+ L S+ Sbjct: 290 SPSE-------------------KEHFYQRQHRLPEPSCPQLAT-----------LTSQC 319 Query: 268 LIYDPAKRISGKMALN 283 L Y+P +R S + L Sbjct: 320 LTYEPTQRPSFRTILR 335 >4WOV-A nrPDB Length = 317 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 56/316 (17%), Positives = 112/316 (35%), Gaps = 72/316 (22%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTG------------------------QVVAMKKIRL 37 ++ T++ +G+GT VY+GR + G V +K + Sbjct: 35 KEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVL-- 92 Query: 38 ESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMD-LKKYLDSIPP 96 + + SL+ ++ H ++ + V ++ ++ E++ L +L Sbjct: 93 DPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERG 152 Query: 97 GQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGT-------IKLADFGL 149 M +V Q+ + + ++ ++H ++ +N+L+ G IKL+D G+ Sbjct: 153 HVPMAWKMV--VAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGV 210 Query: 150 ARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR-YSTPVDIWSIGTIFAELAT-KKPLFHGD 207 G+ V + + +PE L G A ST +D W G E+ + Sbjct: 211 ----GLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSR 266 Query: 208 SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKM 267 S + E ++ P+ LA+ L S+ Sbjct: 267 SPSE-------------------KEHFYQRQHRLPEPSCPQLAT-----------LTSQC 296 Query: 268 LIYDPAKRISGKMALN 283 L Y+P +R S + L Sbjct: 297 LTYEPTQRPSFRTILR 312 >3REP-A nrPDB Length = 271 Score = 110 bits (276), Expect = 6e-25, Method: Composition-based stats. Identities = 51/284 (17%), Positives = 101/284 (35%), Gaps = 44/284 (15%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60 + + K+ E G ++KGR + VV K +++ E L+ H Sbjct: 9 FKQLNFLTKLNENHSGELWKGRWQGNDIVV--KVLKVRDWSTRKSRDFNEECPRLRIFSH 66 Query: 61 PNIVSLQDVLMQDS--RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 PN++ + LI ++ + +D S + + +G+ F Sbjct: 67 PNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAF 126 Query: 119 CHSRR--VLHRDLKPQNLLIDDKGTIKL--ADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174 H+ + L ++++ID+ T ++ AD + F P R+Y + +PE Sbjct: 127 LHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFS--FQSPGRMYA-----PAWVAPEA 179 Query: 175 LLGSARYS--TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 L + D+WS + EL T++ F S ++ ++ Sbjct: 180 LQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKV---------------- 223 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRI 276 +L+ + T P + + L+ + DPAKR Sbjct: 224 ALEGLRPTIP-----------PGISPHVSKLMKICMNEDPAKRP 256 >4L68-A nrPDB Length = 340 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 45/193 (23%), Positives = 81/193 (41%), Gaps = 15/193 (7%) Query: 16 GVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSR 75 G YK G +A+K + S + E++ L ELRH N+ L + + Sbjct: 54 GTTYKA-LLPDGSALAVKHL---STCKLGEREFRYEMNQLWELRHSNLAPLLGFCVVEEE 109 Query: 76 LYLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS---RRVLHRDLKP 131 +L+++++ + L LDS +D S +G+ + H +LH+++ Sbjct: 110 KFLVYKYMSNGTLHSLLDS--NRGELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICS 167 Query: 132 QNLLIDDKGTIKLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDI 187 +LID+ ++ D GLAR T ++ Y +PE + S D+ Sbjct: 168 SVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPE-YSTTMLASLKGDV 226 Query: 188 WSIGTIFAELATK 200 + +G + ELAT Sbjct: 227 YGLGVVLLELATG 239 >5OAT-A nrPDB Length = 411 Score = 100 bits (249), Expect = 9e-22, Method: Composition-based stats. Identities = 68/341 (19%), Positives = 114/341 (33%), Gaps = 97/341 (28%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQ-----VVAMKK------------IRLESEEEG 43 + D + + I +GT GVVY + K A+K I E Sbjct: 10 LNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRET 69 Query: 44 VPSTAIR--------EISLLKELRH----PNIVSLQDVLMQ-----------------DS 74 VP+ EI L +H PNIV++ V + Sbjct: 70 VPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNM 129 Query: 75 RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNL 134 L+L+ + +L+ +L + P + L + L+G+ + + HRDLK NL Sbjct: 130 SLFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQL-----LEGVAHMTAHGIAHRDLKSDNL 184 Query: 135 LID----DKGTIKLADFG--LARAFGIPIRVYTHE----VVTLWYRSPEVLLGSA----- 179 L+D + + ++DFG LA YT +PE++ Sbjct: 185 LLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSV 244 Query: 180 -RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYK 238 YS D+W++G I E+ F+G S + Sbjct: 245 LNYS-KADLWAVGAIAYEIFNCHNPFYGPSRLKNFN------------------------ 279 Query: 239 NTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGK 279 +K G L + L++ +L +P KR+ + Sbjct: 280 -----YKEGDLPKLPDEVPTVIQALVANLLKRNPNKRLDPE 315 >5UV4-A nrPDB Length = 311 Score = 97.2 bits (241), Expect = 8e-21, Method: Composition-based stats. Identities = 48/203 (23%), Positives = 82/203 (40%), Gaps = 12/203 (5%) Query: 8 EKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQ 67 E IG +G YK G ++ +K ++ + REI L +RHPN+V L+ Sbjct: 31 EIIGRSCHGTSYKATL-DNGYMLTVKWLKEGFAKS--KKEFSREIKKLGSVRHPNLVPLR 87 Query: 68 DVL--MQDSRLYLIFEFLS-MDLKKYLDSIPPGQ--YMDSSLVKSYLYQILQGIVFCHSR 122 ++ +I ++ L YL + + + I + + + H+ Sbjct: 88 GYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNE 147 Query: 123 RVL-HRDLKPQNLLI-DDKGTIKLADFGLARAFG-IPIRVYTHEVVTLWYRSPEVLLGSA 179 RV+ H ++K N+LI + + + D+ L R I + L Y PE S Sbjct: 148 RVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTSK 207 Query: 180 RY-STPVDIWSIGTIFAELATKK 201 S D+++ G I EL T K Sbjct: 208 PCPSLKSDVYAFGVILLELLTGK 230 >4IX6-A nrPDB Length = 350 Score = 96.8 bits (240), Expect = 9e-21, Method: Composition-based stats. Identities = 61/335 (18%), Positives = 113/335 (33%), Gaps = 79/335 (23%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN-IVSLQD 68 +G G +G V++G K VV +K + + +++ Sbjct: 28 LGSGNFGTVFRGVFKGDQDVV-LKNAKADVMAAEELLECEMDVNYHVHANAKGTCARFMG 86 Query: 69 VLM----QDSRLYLIFEFLSMDLKK--YLDSIPPGQYMDSSLVKS--------------- 107 + +Y + L + +L G+ +L++ Sbjct: 87 CIELGAKDGGEIY------NGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADAT 140 Query: 108 -------YLYQILQGIVFCHSRRVLHRDLKPQNLLIDDK--GTIKLADFGLARAFGIPIR 158 + ++L + H V+HRD+KP NL+ +K G +KL D G A Sbjct: 141 ELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPE 200 Query: 159 VYTHEVV-----TLWYRSPEVLL---GSARYST-------------PVDIWSIGTIFAEL 197 + + ++ E+ L GS R + D WS G + +L Sbjct: 201 TLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDSWSAGCVMLQL 260 Query: 198 ATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLAS-HVKNL 256 A D+ +++ ++A+G N F K G + L Sbjct: 261 AVVG--LRTDAGLERFLADYKAVG--------------YDVNAFRGEKSGEYGTMDFAAL 304 Query: 257 DEN---GLDLLSKMLIYDPAKRISGKMALNHPYFN 288 D N G DL +++ + R S + AL+H +F+ Sbjct: 305 DANGGAGWDLCQRLMEAERDARASCEAALSHAFFD 339 >6J6I-B nrPDB Length = 351 Score = 96.5 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 33/187 (17%), Positives = 68/187 (36%), Gaps = 12/187 (6%) Query: 27 GQVVAMKKIRLESE--EEGVPSTAIREISL-LKELRHPNIVSLQDVLMQDSRLYLIFEFL 83 + +K+ + + +I L + H N + L ++ L+FEF Sbjct: 81 DRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPVLVFEFA 140 Query: 84 SMDLKKY---LDSIPPGQYMDSSLVKSYLYQILQGIVFCHS---RRVLHRDLKPQNLLID 137 + + S+ +I + + H+ + ++HRD+KP ++ +D Sbjct: 141 EHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLD 200 Query: 138 DKGTIKLADFGLARAFGIPIRVYTHE--VVTLWYRSPEVLLGSARYSTPVDIWSIGTIFA 195 T KL+D + + E + T Y P + + + D++S G Sbjct: 201 KNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYSFGICLL 259 Query: 196 ELATKKP 202 + T KP Sbjct: 260 VIITGKP 266 >6EQI-C nrPDB Length = 433 Score = 93.8 bits (232), Expect = 7e-20, Method: Composition-based stats. Identities = 63/350 (18%), Positives = 105/350 (30%), Gaps = 103/350 (29%) Query: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTG-----QVVAMKKI---RLESEEEGVPSTAIRE- 51 +++ E I +G VVY + K +A+K + +ES + RE Sbjct: 14 LDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRET 73 Query: 52 --------------ISLLKELR-----HPNIVSLQDVLMQ-------------------- 72 I + + + HPNIV + V Sbjct: 74 VPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRI 133 Query: 73 -------DSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 125 + L+L+ + LK+YL P L+ L + + + + Sbjct: 134 NPEGSGRNMSLFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQLL----EAVAHMNIHNIS 189 Query: 126 HRDLKPQNLLI-----DDKGTIKLADFGLA-----RAFGIPIRVYTHEV-VTLWYRSPEV 174 HRDLK N+L+ D TI + DFG IP R + +PE+ Sbjct: 190 HRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEI 249 Query: 175 LLGS-ARYS----TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 +S D+W++G I E+ F+ Sbjct: 250 ANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYD----------------------- 286 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGK 279 + K +K L + +L+S ML KR+ Sbjct: 287 -----KTMKLLSKSYKEEDLPELPDTIPFIIRNLVSNMLSRSTNKRLDCD 331 >5UU1-A nrPDB Length = 324 Score = 84.9 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 43/229 (18%), Positives = 79/229 (34%), Gaps = 29/229 (12%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEG------------VPSTAI 49 + +KIG G +G++Y + A +++E +E G I Sbjct: 16 NQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKKDCI 75 Query: 50 REISLLKELRHPNIVSLQDV----LMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLV 105 ++ K+L + I S +++ E L +DL+K S V Sbjct: 76 KKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI---SGQNGTFKKSTV 132 Query: 106 KSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKG--TIKLADFGLARAFGIPIRV---- 159 ++L + + H +H D+K NLL+ K + LAD+GL+ + Sbjct: 133 LQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQ 192 Query: 160 ---YTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFH 205 T+ + S + G S D+ +G K + Sbjct: 193 ENPRKGHNGTIEFTSLDAHKG-VALSRRSDVEILGYCMLRWLCGKLPWE 240 >5CLR-A nrPDB Length = 451 Score = 83.4 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 36/186 (19%), Positives = 71/186 (38%), Gaps = 17/186 (9%) Query: 19 YKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSR--L 76 +K G+ +K +++++E + E L +L L + Sbjct: 96 FKVYALDDGKTYFLKSVKIDAES---LTEFTNEKDTLSKLG-----RLVGTFFNEQTQVH 147 Query: 77 YLIFEFLSM-DLKKYLDSIPPGQYMDS-SLVKSYLYQILQGIVFCHSRRVLHRDLKPQNL 134 Y++ F+ DL +Y +++P + V + + + H ++HRDLKP N+ Sbjct: 148 YILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNI 207 Query: 135 LIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV--LLGSARYSTPVDIWSIGT 192 ++D L DFG + T Y +PE+ +S D++++ Sbjct: 208 MLDADMQCHLVDFGSS---SSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAY 264 Query: 193 IFAELA 198 EL Sbjct: 265 SLDELF 270 >4O1O-A nrPDB Length = 717 Score = 80.3 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 54/302 (17%), Positives = 103/302 (34%), Gaps = 79/302 (26%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR-H 60 E+Y KI + G +Y G ++ Q VA+K+ S +E+S L+ R + Sbjct: 350 EEY----KIADTAEGGIYLGLYED--QEVAVKRFSEGST------RGQQEVSCLQSSRAN 397 Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSL--VKSYLYQILQGIVF 118 N+V+ S L++ L+++L + + ++ L + + I Sbjct: 398 DNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGE 457 Query: 119 CHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGS 178 H H+DL+PQN+LID K LADF + + + Sbjct: 458 LHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKR---------------- 501 Query: 179 ARYSTPVDIWSIG-TIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 237 D+ ++G + + F + +S ++ Sbjct: 502 -------DLEALGLLVLYVVKKGDISFET----------------------LKNQSFEEV 532 Query: 238 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIY--DPAKRISGKMALNHPYFNDLDNQIK 295 P DE DL+ + + R+S L HP+F +++ + Sbjct: 533 IQGSP--------------DEETRDLIHHLFHPGDNVEDRLSS--LLAHPFFWSWESRYR 576 Query: 296 KM 297 + Sbjct: 577 TL 578 >4OAU-C nrPDB Length = 699 Score = 76.0 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 39/143 (27%), Positives = 61/143 (42%), Gaps = 12/143 (8%) Query: 9 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR-HPNIVSLQ 67 KI + + G +Y G + Q VA+K S A RE+S L+ R + ++V+ Sbjct: 350 KIADTSEGGIYLGFY--EKQEVAVKTFCEGSP------RAQREVSCLQSSRENSHLVTFY 401 Query: 68 DVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSL--VKSYLYQILQGIVFCH-SRRV 124 L++ L+ LD + ++ L I + + H S Sbjct: 402 GSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY 461 Query: 125 LHRDLKPQNLLIDDKGTIKLADF 147 H+DL+PQN+LID K LADF Sbjct: 462 THQDLQPQNILIDSKKAAHLADF 484 Score = 29.1 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 9/41 (21%), Positives = 18/41 (43%) Query: 257 DENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297 DE DL+ ++ R L HP+F +++ + + Sbjct: 536 DEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTL 576 >4CI6-B nrPDB Length = 643 Score = 74.9 bits (183), Expect = 4e-14, Method: Composition-based stats. Identities = 56/288 (19%), Positives = 108/288 (37%), Gaps = 38/288 (13%) Query: 24 KTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD--VLMQDSRLY--LI 79 K ++VA K R +E + +HPN+ ++ V+ +R Y L+ Sbjct: 66 KDKQRLVA-KIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYYYALL 124 Query: 80 FEF-----LSMDLKKYLDSIPPGQYMDSS---LVKSYLYQILQGIVFCHSRRVLHRDLKP 131 + S L+ DS G+ + +K +++L ++H D+KP Sbjct: 125 MDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIKP 184 Query: 132 QNLLIDD-KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSI 190 N++ D G + D GL G + +T +++PE+ +G+ S D++ Sbjct: 185 GNVVFDRASGEPVVIDLGLHSRSGEQPKGFTES-----FKAPELGVGNLGASEKSDVF-- 237 Query: 191 GTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLA 250 + + L F D EI + R + + V E N +P +PG Sbjct: 238 -LVVSTLLHGIEGFEKDPEIKP-NQGLRFITSEPAHVMDE--------NGYPIHRPG--- 284 Query: 251 SHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND--LDNQIKK 296 + ++ ++ +L R A H + +D +D + K Sbjct: 285 --IAGVETAYTRFITDILGVSADSRPDSNEARLHEFLSDGTIDEESAK 330 >2RSV-A nrPDB Length = 403 Score = 73.4 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 41/237 (17%), Positives = 85/237 (35%), Gaps = 38/237 (16%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVV---AMKKIRLESEEEGVPSTAIREISLL--- 55 +++ IG+G +G +Y + + V A +++E + G E+ Sbjct: 42 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGP---LFTELKFYQRA 97 Query: 56 ------------KELRHPNIVSLQDVLMQD----SRLYLIFEFLSMDLKKYLDSIPPGQY 99 ++L++ + + D S ++I + DL+K ++ + Sbjct: 98 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEA--NAKR 155 Query: 100 MDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKG--TIKLADFGLARAFGIPI 157 V +IL + + H +H D+K NLL++ K + L D+GLA + Sbjct: 156 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEG 215 Query: 158 -------RVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGD 207 T+ + S + G A S D+ +G + T + + Sbjct: 216 VHKEYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDN 271 >6G4J-A nrPDB Length = 315 Score = 73.0 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 42/227 (18%), Positives = 80/227 (35%), Gaps = 30/227 (13%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63 YT +++G+G G+VY T+ VA+K + E+++LK Sbjct: 28 YTLRKQLGKGANGIVYLAE--TSDGHVALKV-------SDDSLSITSEVNVLKSFSKAQS 78 Query: 64 VSLQDVLMQDSRLYL----------IFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQIL 113 V++ Y+ E++ L L + + + Q+L Sbjct: 79 VTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPL--LLKYVSDKGA---EWIPVLMIQLL 133 Query: 114 QGIVFCHSRRVLHRDLKPQNLLIDD-KGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSP 172 + H + + DLKP NL++ I+ D G G I+ YT ++ Sbjct: 134 SSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYDRGYWG-- 191 Query: 173 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRA 219 G+ + D++++ I KK + +QL + Sbjct: 192 ---YGTRKAEPSYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSLIEG 235 >2LAV-A nrPDB Length = 361 Score = 71.8 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 41/237 (17%), Positives = 85/237 (35%), Gaps = 38/237 (16%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVV---AMKKIRLESEEEGVPSTAIREISLL--- 55 +++ IG+G +G +Y + + V A +++E + G E+ Sbjct: 35 KEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGP---LFTELKFYQRA 90 Query: 56 ------------KELRHPNIVSLQDVLMQD----SRLYLIFEFLSMDLKKYLDSIPPGQY 99 ++L++ + + D S ++I + DL+K ++ + Sbjct: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEA--NAKR 148 Query: 100 MDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKG--TIKLADFGLARAFGIPI 157 V +IL + + H +H D+K NLL++ K + L D+GLA + Sbjct: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEG 208 Query: 158 -------RVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGD 207 T+ + S + G A S D+ +G + T + + Sbjct: 209 VHKEYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEILGYCMIQWLTGHLPWEDN 264 >6EAS-A nrPDB Length = 308 Score = 70.3 bits (171), Expect = 9e-13, Method: Composition-based stats. Identities = 46/290 (15%), Positives = 98/290 (33%), Gaps = 45/290 (15%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAM---KKIRLESEEEGVPSTAIREISLLKEL 58 ED++ I IG + ++YKG ++G +A+ + + S ++I+ L ++ Sbjct: 42 EDFSNI--IGSTSTCMLYKGTL-SSGVEIAVASSLVTSAKDWSKENESQYRKKITNLSKV 98 Query: 59 RHPNIVSLQDVLMQDSRL--YLIFEFL-SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQG 115 H N ++L ++ ++FE+ + L ++L + + +D I Sbjct: 99 SHKNFMNLLGYCEEEHPFTRVMVFEYAPNGTLFEHLH-VREAEKLDWMARLRISMGIAYC 157 Query: 116 IVFCHSRRV--LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPE 173 + H + R+ + + D K++D +E+ SP+ Sbjct: 158 LEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDLEFWNDAKGHNSTTNNELA----FSPD 213 Query: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQ--LFRIFRALGTPNNEVWPEV 231 + +Y G + E+ T + D + + R F + P + Sbjct: 214 MEDIVRKY---------GMVLLEILTGRVPSSEDDGPLENWVSRYFEGGMRLEELIDPSI 264 Query: 232 ESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 FP+ +L + + DP KR K Sbjct: 265 G-------FFPEDTARALCEV-----------VRSCIDRDPKKRPQMKEV 296 >5DMZ-A nrPDB Length = 365 Score = 69.5 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 45/282 (15%), Positives = 90/282 (31%), Gaps = 39/282 (13%) Query: 10 IGEGTYGVVYKGR-----HKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIV 64 +GEG + VY+ Q +K + + E T + E L ++H + Sbjct: 73 LGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLME-RLKPSMQHMFM- 130 Query: 65 SLQDVLMQDSRLYLIFEFLSMDLKKY---LDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 + + L+ E S L P + M LV S+ ++L I H Sbjct: 131 KFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHD 190 Query: 122 RRVLHRDLKPQNLLIDD-----------KGTIKLADFGLARAFG--IPIRVYTHEVVTLW 168 ++H D+KP N ++ + + L D G + ++T + T Sbjct: 191 CEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSG 250 Query: 169 YRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVW 228 ++ E+L ++ +D + + + + ++ Sbjct: 251 FQCVEMLSNK-PWNYQIDYFGVAATVYCMLFGTY----------MKVKNEGGECKPEGLF 299 Query: 229 PEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIY 270 + L + F H+ +L DLL + L Sbjct: 300 RRLPHLDMWNEFFHVMLNIPDCHHLPSL-----DLLRQKLKK 336 >2JII-A nrPDB Length = 352 Score = 62.2 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 30/171 (17%), Positives = 64/171 (37%), Gaps = 13/171 (7%) Query: 70 LMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDL 129 + QD +L+ L L+ LD + P + V ++L + F H +H ++ Sbjct: 127 VHQDKYRFLVLPSLGRSLQSALD-VSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNV 185 Query: 130 KPQNLLID--DKGTIKLADFGLARAFGIPIRVYTHEVVTL-------WYRSPEVLLGSAR 180 +N+ +D D+ + LA +G A + + + + + S ++ G Sbjct: 186 TAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGP 245 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGD--SEIDQLFRIFRALGTPNNEVWP 229 S D+ S+G + + + D + + + + P V P Sbjct: 246 -SRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGP 295 >5GZA-A nrPDB Length = 290 Score = 60.6 bits (146), Expect = 7e-10, Method: Composition-based stats. Identities = 36/216 (16%), Positives = 68/216 (31%), Gaps = 49/216 (22%) Query: 6 KIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVS 65 +++ IG+G VY + GQ VA+ + + + +S+L+ L+ ++V+ Sbjct: 29 RVKLIGQGAVKKVYLSEWQ--GQKVALSVL----SSDQYADDFLHGLSMLRALQSSHVVT 82 Query: 66 LQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYM----DSSLVKSYLYQILQGIVFCHS 121 L V +D + E+ + LD+ + + + + HS Sbjct: 83 LVGVCEED--AVFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVAFLAYLHS 140 Query: 122 R--RV--------LHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVV------ 165 + LH+ L L+ + LA V + Sbjct: 141 SPAGIRVMCDSNDLHKTL--SQFLLASDMRL------LANDLDALPEVEKGGLGVKCGHH 192 Query: 166 --TLWYRSPEVL-----------LGSARYSTPVDIW 188 T + +PE L Y DIW Sbjct: 193 ELTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >6M7Z-A nrPDB Length = 319 Score = 60.3 bits (145), Expect = 9e-10, Method: Composition-based stats. Identities = 39/239 (16%), Positives = 77/239 (32%), Gaps = 57/239 (23%) Query: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120 P++ + + IF LS L + V+ ++ + H Sbjct: 111 PSLGEYRGAFLTY-----IFHPLSKGLVGDMLETGRSH----PDVQVLAANMVAALKSLH 161 Query: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV------ 174 + +LHR ++ + + GT+ L A G R++ +PE+ Sbjct: 162 NLGLLHRSIELNSFSVLPDGTVVLGGLDTAAPIGTETRLWVGFFGQE--TAPEIDRNFLA 219 Query: 175 --LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 232 L R++ D++S+G + + LG N Sbjct: 220 DLALTQGRHTVKSDVYSLGV-------------------AFRNLVQLLGNGNLG------ 254 Query: 233 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLD 291 P+ + H++ LD+ L KM+ +P R + + + P F L+ Sbjct: 255 ---------PEDRGAVRQDHLELLDK----LSQKMIEEEPGNRPTIEEIMKDPLFEGLN 300 >4CYJ-A nrPDB Length = 438 Score = 57.6 bits (138), Expect = 6e-09, Method: Composition-based stats. Identities = 31/140 (22%), Positives = 59/140 (42%), Gaps = 14/140 (10%) Query: 18 VYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQD--SR 75 VYK ++ G+ A++ RLE + + K++++ +IV++ +V Sbjct: 71 VYKAQNSRNGRHYALR--RLEGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFTTREFGD 128 Query: 76 LYLIFEFLSMDLKKYLD----------SIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVL 125 LIF + L K L P + + + Y+ QI + HS R+ Sbjct: 129 SSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTIHSNRLA 188 Query: 126 HRDLKPQNLLIDDKGTIKLA 145 R L+P +++ D I+L+ Sbjct: 189 ARCLEPSKIILTDINRIRLS 208 >5GZ9-A nrPDB Length = 305 Score = 57.2 bits (137), Expect = 8e-09, Method: Composition-based stats. Identities = 32/209 (15%), Positives = 66/209 (31%), Gaps = 36/209 (17%) Query: 7 IEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL 66 ++++GEG V+ K VA+ ++ + + + +LK L+ ++V+L Sbjct: 39 LKRVGEGAVKRVFLSEWKE--HKVALSRL----TRLEMKEDFLHGLQMLKSLQSEHVVTL 92 Query: 67 QDVLMQDSRLYLIFEFLSMD----LKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 +D ++ E+ + L++ L + + I + H Sbjct: 93 VGYCEEDGT--ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIINYLHHS 150 Query: 123 RVLHRDLKPQN--------LLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLW----YR 170 + R + N L+ +I D A + + Sbjct: 151 PLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLD-ALPLVDHDSGVLIKCGHRELHGDFV 209 Query: 171 SPEVLLGSA-----------RYSTPVDIW 188 +PE L Y+ VDIW Sbjct: 210 APEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >6EWX-A nrPDB Length = 484 Score = 52.9 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 34/223 (15%), Positives = 56/223 (25%), Gaps = 71/223 (31%) Query: 102 SSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKG--------------------- 140 V L Q+ G+ ++HRDL +NLL+ Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCP 268 Query: 141 --------------------TIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180 + +++F A+ + +PE++ S Sbjct: 269 SAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQAR-LAPEIVSASQY 327 Query: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 D + G + EL + F EV ++ + Sbjct: 328 --RKFDEFQTGILIYELLHQPNPF---------------------EVRAQLRERDYRRED 364 Query: 241 FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 P SL L +L DP KRI A Sbjct: 365 LPPLPTLSLY------SPGLQQLAHLLLEADPIKRIRIGEAKR 401 >4AZW-A nrPDB Length = 471 Score = 52.6 bits (125), Expect = 2e-07, Method: Composition-based stats. Identities = 24/118 (20%), Positives = 43/118 (36%), Gaps = 12/118 (10%) Query: 35 IRLESEEEGVPSTAIREISLLKE----LRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKY 90 I E + EI L + P + +L+ E L L Sbjct: 275 ILTAEESQRNKHELHNEIKFLTQPPAGFDAPAV---LAHGENAQSGWLVMEKLPGRLLS- 330 Query: 91 LDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFG 148 D + G+ +D L +L+ + + H D++P N+++D + +L DFG Sbjct: 331 -DMLAAGEEIDRE---KILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDFG 384 >4AZV-A nrPDB Length = 569 Score = 52.2 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 24/118 (20%), Positives = 43/118 (36%), Gaps = 12/118 (10%) Query: 35 IRLESEEEGVPSTAIREISLLKE----LRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKY 90 I E + EI L + P + +L+ E L L Sbjct: 275 ILTAEESQRNKYELHNEIKFLTQPPAGFDAPAV---LAHGENAQSGWLVMEKLPGRLLS- 330 Query: 91 LDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFG 148 D + G+ +D L +L+ + + H D++P N+++D + +L DFG Sbjct: 331 -DMLAAGEEIDRE---KILGSLLRSLAALEKQGFWHDDVRPWNVMVDARQHARLIDFG 384 >4BWP-A nrPDB Length = 448 Score = 51.8 bits (123), Expect = 4e-07, Method: Composition-based stats. Identities = 28/165 (16%), Positives = 57/165 (34%), Gaps = 40/165 (24%) Query: 19 YKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQ----DS 74 Y+ H TTG +R + + + + K+L+H N+V L++V D+ Sbjct: 67 YRATHNTTGYKY---CLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGDN 123 Query: 75 RLYLIFEFLSMD---LKKYL--------------------------DSIPPGQYMDSSLV 105 L L++++ L KY G + + + Sbjct: 124 SLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATI 183 Query: 106 KSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGT----IKLAD 146 S + Q+ G+ H + + L P +++ K ++D Sbjct: 184 WSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >3Q60-A nrPDB Length = 371 Score = 50.6 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 51/332 (15%), Positives = 98/332 (29%), Gaps = 69/332 (20%) Query: 3 DYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPN 62 +E + G VV+ R + A+K + +E + E + Sbjct: 63 KLKLVEPLRVGDRSVVFLVRDVERLEDFALKVFTMGAENSRSELERLHEATFAA------ 116 Query: 63 IVSLQD-------------------VLMQDSRL---------------YLIFEFLSMDLK 88 L + L+ S+DL+ Sbjct: 117 -ARLLGESPEEARDRRRLLLPSDAVAVQSQPPFAQLSPGQDDYAVANYLLLMPAASVDLE 175 Query: 89 KYLDSIPPGQYM--DSSLVKS--YLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKL 144 ++ D ++ Q+++ S+ ++H P NL I G + L Sbjct: 176 LLFSTLDFVYVFRGDEGILALHILTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLML 235 Query: 145 ADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL-GSARYSTPVDIWSIGTIFAELATKKPL 203 D ++ + + R V + Y E L +A ++ ++ W +G + Sbjct: 236 GD--VSALWKVGTRGPASSV-PVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLP 292 Query: 204 FHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDL 263 F L TP + S + P + S L + L Sbjct: 293 F--------------GLVTPGIK-----GSWKRPSLRVPGTDSLAFGSCTP-LPDFVKTL 332 Query: 264 LSKMLIYDPAKRISGKMALNHPYFNDLDNQIK 295 + + L +D +R+ A+ P F L N+I Sbjct: 333 IGRFLNFDRRRRLLPLEAMETPEFLQLQNEIS 364 >3ENH-A nrPDB Length = 540 Score = 50.2 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 29/158 (18%), Positives = 57/158 (36%), Gaps = 24/158 (15%) Query: 10 IGEGTYGVVYKGRHKTTGQVVAMK-KIRLESEEEGVPSTAI-----REISLLKELRHPNI 63 IG+G + R V +K +++ +E + RE L ++ I Sbjct: 344 IGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFGI 401 Query: 64 VS--LQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHS 121 + + DV + + R+ +++ L K + Y+I + + H Sbjct: 402 PAPYIFDVDLDNKRIM--MSYINGKLAKDVIEDN----------LDIAYKIGEIVGKLHK 449 Query: 122 RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV 159 V+H DL N + D + + DFGL + + Sbjct: 450 NDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDEDK 485 >3BYV-A nrPDB Length = 377 Score = 50.2 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 42/318 (13%), Positives = 99/318 (31%), Gaps = 79/318 (24%) Query: 20 KGRHKTTGQVV--------------AMKKIRLES---------EEEGVPSTAIREISLLK 56 + + TG+ A+K+++ E + + +R I Sbjct: 91 EATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFD 150 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEF-----LSMDLKKY----LDSIPPGQYMDSSLVKS 107 ++ P + V + + ++++ F + +L+ + L + + Sbjct: 151 LVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQ 210 Query: 108 YLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTL 167 Q+++ + H ++H L+P ++++D +G + L F + V+ Sbjct: 211 LTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF----EHLVRDGARVVSSVSR 266 Query: 168 WYRSPEVLLGSARY----------STPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIF 217 + PE+ A + D W++G + + D+ + IF Sbjct: 267 GFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLPITKDAALGGSEWIF 326 Query: 218 RALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRIS 277 R+ KN+ + LL L Y R+ Sbjct: 327 RS---------------------------------CKNIPQPVRALLEGFLRYPKEDRLL 353 Query: 278 GKMALNHPYFNDLDNQIK 295 A+ P + L ++ Sbjct: 354 PLQAMETPEYEQLRTELS 371 >4WWA-A nrPDB Length = 261 Score = 49.1 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 31/154 (20%), Positives = 50/154 (32%), Gaps = 29/154 (18%) Query: 19 YKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR---------HPNIVSLQDV 69 Y R K + Q +K + A+ + L E R + L Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC 97 Query: 70 LMQDSRLYLIFEFLSMDLKK-----------YLDSIPPGQYMDSSLVKSYLYQILQGIVF 118 + ++L EFL DL ++ P + ++ ++ QI Sbjct: 98 DPYNGFIWL--EFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGL---- 151 Query: 119 CHSRRVLHRDLKPQNLLIDDKG---TIKLADFGL 149 H H DL N+++ G T L DFGL Sbjct: 152 LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >5VE6-A nrPDB Length = 492 Score = 47.5 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 11/35 (31%), Positives = 17/35 (48%) Query: 102 SSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLI 136 V L Q+ G+ ++HRDL +NLL+ Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 Score = 33.7 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 19/114 (16%), Positives = 33/114 (28%), Gaps = 29/114 (25%) Query: 170 RSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWP 229 +PE++ S D + G + EL + F +++ + Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELLHQPNPFEVRAQLRE----------------- 365 Query: 230 EVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 +DY+ P + L +L DP KRI A Sbjct: 366 -----RDYRQEDLPPLPA-----LSLYSPGLQQLAHLLLEADPIKRIRIGEAKR 409 >6G38-A nrPDB Length = 357 Score = 47.2 bits (111), Expect = 8e-06, Method: Composition-based stats. Identities = 39/180 (21%), Positives = 61/180 (33%), Gaps = 53/180 (29%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE------SEEEGVPSTAIREISLL 55 E + EKIGEG +G V++ T VA+K I +E + + EI + Sbjct: 41 EKLQRCEKIGEGVFGEVFQTIADHT--PVAIKIIAIEGPDLVNGSHQKTFEEILPEIIIS 98 Query: 56 KE-----------------LRHPNIVS------LQDV----------------LMQDSRL 76 KE L + V L +D +L Sbjct: 99 KELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQL 158 Query: 77 YLIFEFLSMDLKKYLDSIPPGQYMDS-SLVKSYLYQILQGIVFCH-SRRVLHRDLKPQNL 134 +++ EF +D + S + KS L+Q+ + S R HRDL N+ Sbjct: 159 FIVLEFEFGG----IDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >3DZO-A nrPDB Length = 413 Score = 46.0 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 42/315 (13%), Positives = 99/315 (31%), Gaps = 74/315 (23%) Query: 20 KGRHKTTGQVV--------------AMKKIRLES---------EEEGVPSTAIREISLLK 56 + + TG+ A+K+++ E + + +R I Sbjct: 96 EATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFD 155 Query: 57 ELRHPNIVSLQDVLMQDSRLYLIFEF-----LSMDLKKY----LDSIPPGQYMDSSLVKS 107 ++ P + V + + ++++ F + +L+ + L + + Sbjct: 156 LVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQ 215 Query: 108 YLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFG-LARAFGIPIRVYTHEVVT 166 Q+++ + H ++H L+P ++++D +G + L F L R + Sbjct: 216 LTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGFEHLVRDGASAVSPIGRGFAP 275 Query: 167 LWYRSPEVLLGSARY-----STPVDIWSIGT-IFAELATKKPLFHGDSEIDQLFRIFRAL 220 + E +L ++ + D W++G I+ P Sbjct: 276 PETTA-ERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLP------------------ 316 Query: 221 GTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKM 280 + D +W + KN+ + LL L Y R+ Sbjct: 317 ------------NTDDAALGGSEW----IFRSCKNIPQPVRALLEGFLRYPKEDRLLPLQ 360 Query: 281 ALNHPYFNDLDNQIK 295 A+ P + L ++ Sbjct: 361 AMETPEYEQLRTELS 375 >6BHC-A nrPDB Length = 438 Score = 46.0 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 41/294 (13%), Positives = 85/294 (28%), Gaps = 75/294 (25%) Query: 30 VAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLM----------------QD 73 A+K + +++E ++ L H NI + Q Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAV--HFNIQQDCGHFLAEVPNRLLPWEDPSKKQR 143 Query: 74 SRLYLIF-EFLSMDLKKYLD----SIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRD 128 S + +I E + + ++ + V L Q+ G+ V H D Sbjct: 144 SHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCD 203 Query: 129 LKPQNLLIDD---------------------KGTIKLADFGLARAFGIPIRVYTHEVVTL 167 L+ +NLL+ + +++F A+ + + Sbjct: 204 LRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSR 263 Query: 168 WYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEV 227 +PE++ + D + G + E+ F + Sbjct: 264 --LAPEIITATQY--KKCDEFQTGILIYEMLHLPNPFDEN-------------------- 299 Query: 228 WPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMA 281 PE++ + + P+ S L S +L +P++RI A Sbjct: 300 -PELKEREYTRADLPRIPFRS------PYSRGLQQLASCLLNPNPSERILISDA 346 >4CZY-B nrPDB Length = 429 Score = 44.1 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 29/140 (20%), Positives = 59/140 (42%), Gaps = 16/140 (11%) Query: 19 YKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQ----DS 74 YK ++ G+ A+++I E + K++ + NIV++ + DS Sbjct: 61 YKAQNNKNGRHFALRRI--EGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTTEFFGDS 118 Query: 75 RLYLIFEFLSMDLKKYLDSIPPGQ---------YMDSSLVKSYLYQILQGIVFCHSRRVL 125 L +++F + Y PP + +L+ SY+ QI ++ H+ ++ Sbjct: 119 SLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKLA 178 Query: 126 HRDLKPQNLLIDDKGTIKLA 145 R L+ + I + I+LA Sbjct: 179 ARCLELSKI-IWENNRIRLA 197 >2W1Z-A nrPDB Length = 368 Score = 43.7 bits (102), Expect = 9e-05, Method: Composition-based stats. Identities = 24/156 (15%), Positives = 50/156 (32%), Gaps = 5/156 (3%) Query: 90 YLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFG- 148 L + + Q+++ ++H D + +N+L+D +G + L F Sbjct: 178 LLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLTGFEH 237 Query: 149 LARAFGIPIRVYTHEVVTLWYRSPEVLLGSARY----STPVDIWSIGTIFAELATKKPLF 204 L R + + +L + + P D W++G + Sbjct: 238 LVRDGASAVSPIGRGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCADLPN 297 Query: 205 HGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT 240 D+E+ + I+R V +E Y Sbjct: 298 TEDAELGGIEWIYRRCKNIPQPVRALLEGFLRYSKE 333 >1TQM-A nrPDB Length = 282 Score = 41.4 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 28/167 (16%), Positives = 60/167 (35%), Gaps = 29/167 (17%) Query: 6 KIEKIGEGTYGVVYKGRHKTTGQVVAM---------KKIRLESE------EEGVPSTAIR 50 + +GEG V+ + G+ V KK++ + + +A Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 51 EISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLY 110 E L++L+ + + ++ E + + P + +D Sbjct: 154 EFRALQKLQGLAVPKVYAWEGNA----VLMELIDAKELYRVRVENPDEVLDM-------- 201 Query: 111 QILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI 157 IL+ + + R ++H DL N+L+ ++G I + DF + G Sbjct: 202 -ILEEVAKFYHRGIVHGDLSQYNVLVSEEG-IWIIDFPQSVEVGEEG 246 >5YK0-A nrPDB Length = 452 Score = 38.7 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 27/167 (16%), Positives = 60/167 (35%), Gaps = 35/167 (20%) Query: 16 GVVYKGRHKTTGQVVAMKKIRLESEE--EGVPSTAIREISLLKELR-HPNIVSLQDVLMQ 72 G V+K + G+ VA+K ++E T R + +LK+L ++ + D L++ Sbjct: 146 GQVHKAIW-SDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 73 DSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLV-----KSYLYQILQGIVFCH------- 120 + + L + + + + + + V K + + ++G+ Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTT 264 Query: 121 -------------------SRRVLHRDLKPQNLLIDDKGTIKLADFG 148 ++H D P N ++ G + + DFG Sbjct: 265 EQRDLIGTLLAELTFDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFG 311 >6FAI-l nrPDB Length = 425 Score = 34.1 bits (77), Expect = 0.070, Method: Composition-based stats. Identities = 29/173 (16%), Positives = 52/173 (30%), Gaps = 42/173 (24%) Query: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRL---------------ESEEEGVPSTA 48 Y+ IG G +YK K V MK RL + +G Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Query: 49 I------REISLLKEL--RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYM 100 + +E + L + + D +SR ++ E + + L + Sbjct: 154 LSRLAANKEYQFMSMLYSKGFKVPEPFD----NSRHIVVMELIEGYPMRRLRKHKNIPKL 209 Query: 101 DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDD------KGTIKLADF 147 S L+ + + ++H D N++I D + DF Sbjct: 210 YSDLMCFIV--------DLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >6DFL-A nrPDB Length = 259 Score = 33.7 bits (76), Expect = 0.093, Method: Composition-based stats. Identities = 22/168 (13%), Positives = 55/168 (32%), Gaps = 17/168 (10%) Query: 11 GEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSL---- 66 G G + +++G G+ + + A +E ++ L + ++ Sbjct: 45 GRGYFVKIHRGI--GWGE-----IAKNLLTAKLPVLGARQEWQAIRRLHEAGVATMTAVA 97 Query: 67 ---QDVLMQDSRLYLIFEFLSMDL-KKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSR 122 + +++ E L+ + + + L ++ + + + + H Sbjct: 98 YGERGSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHRA 157 Query: 123 RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYR 170 V HRD + L+ + DF L+ R T + +R Sbjct: 158 GVNHRDCYICHFLLHTDKPVSADDFRLSVI--DLHRAQTRDATPKRWR 203 >6G18-v nrPDB Length = 552 Score = 33.3 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 21/103 (20%), Positives = 42/103 (40%), Gaps = 14/103 (13%) Query: 47 TAIREISLLKEL--RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSL 104 +A++E + +K L R + D +R ++ E ++ P Q Sbjct: 157 SAMKEFAYMKALYERKFPVPKPIDY----NRHAVVMELING--------YPLCQIHHVED 204 Query: 105 VKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADF 147 S + ++ IV + ++H D NL++D+ I + DF Sbjct: 205 PASVYDEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDF 247 >4FDJ-A nrPDB Length = 502 Score = 33.3 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 26/124 (20%), Positives = 41/124 (33%), Gaps = 29/124 (23%) Query: 172 PEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHG-DSEIDQLFRIFRA-------LGTP 223 PE+L + S V W +G +P FH D+ F P Sbjct: 99 PELLKKAGYVSKIVGKWHLG--------HRPQFHPLKHGFDEWFGSPNCHFGPYDNKARP 150 Query: 224 NNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALN 283 N V+ + E + Y FP A+ + + LD + + A + Sbjct: 151 NIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKR-------------QARH 197 Query: 284 HPYF 287 HP+F Sbjct: 198 HPFF 201 >6FDN-A nrPDB Length = 320 Score = 32.1 bits (72), Expect = 0.31, Method: Composition-based stats. Identities = 21/103 (20%), Positives = 42/103 (40%), Gaps = 14/103 (13%) Query: 47 TAIREISLLKEL--RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSL 104 +A++E + +K L R + D +R ++ E ++ P Q Sbjct: 157 SAMKEFAYMKALYERKFPVPKPIDY----NRHAVVMELING--------YPLCQIHHVED 204 Query: 105 VKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADF 147 S + ++ IV + ++H D NL++D+ I + DF Sbjct: 205 PASVYDEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDF 247 >3F7W-A nrPDB Length = 288 Score = 29.8 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 11/67 (16%), Positives = 23/67 (34%), Gaps = 5/67 (7%) Query: 82 FLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC----HSRRVLHRDLKPQNLLID 137 + + YL + V+ + ++L + +H DL N+L Sbjct: 145 YAEQRILPYLRRAADRGALTPGDVR-LVEKVLDALDHLAGDPEPPARIHGDLWNGNVLWQ 203 Query: 138 DKGTIKL 144 D G + + Sbjct: 204 DDGAVVI 210 >6EF6-A nrPDB Length = 354 Score = 29.8 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 11/28 (39%), Positives = 17/28 (60%), Gaps = 3/28 (10%) Query: 123 RVLHRDLKPQNLLIDD---KGTIKLADF 147 ++H DL+ NLL+D + TI + DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >2HZ7-A nrPDB Length = 851 Score = 29.4 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 24/125 (19%), Positives = 42/125 (33%), Gaps = 13/125 (10%) Query: 144 LADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDI-WSIGTIFAELATKKP 202 L DF AR +G + + PE+ S D+ W +G L + Sbjct: 88 LLDFNTARQYGGQFNLRMDDTN------PELARQEYVDSIADDLKW-LG-----LDWGEH 135 Query: 203 LFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLD 262 ++ D+ + L + V + + PG+ + + E LD Sbjct: 136 FYYASDYFDRYYAYAEQLIRQGDAYVESVSPEELSRLRGNATTPGTPSPYRDRSVEENLD 195 Query: 263 LLSKM 267 LL +M Sbjct: 196 LLRRM 200 >4GYG-A nrPDB Length = 397 Score = 29.1 bits (64), Expect = 2.2, Method: Composition-based stats. Identities = 24/174 (13%), Positives = 48/174 (27%), Gaps = 37/174 (21%) Query: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHP 61 + Y+ +IG G + + Q V +K RL + Sbjct: 95 DVYSVGSRIGVGKESDIMIVADEKGKQKV-LKIHRLGRISFRTVKANRDYLRNRSTGSWM 153 Query: 62 NIVSLQDV--LMQDSRLY----------------LIFEFLSMDLKKYLDSIPPGQYMDSS 103 + L + LY ++ +D++P Q Sbjct: 154 YLSRLAAIKEFAFMKALYEEGFPVPEPIAQSRHTIVM--------SLVDALPMRQVSSVP 205 Query: 104 LVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIK----------LADF 147 S ++ I+ ++H D N+LI ++ + + DF Sbjct: 206 DPASLYADLIALILRLAKHGLIHGDFNEFNILIREEKDAEDPSSITLTPIIIDF 259 >6EN4-C nrPDB Length = 852 Score = 29.1 bits (64), Expect = 2.2, Method: Composition-based stats. Identities = 15/78 (19%), Positives = 34/78 (43%), Gaps = 9/78 (11%) Query: 190 IGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSL 249 +G + E ++ S + L I +G +++ P ++ L P+ P L Sbjct: 522 LGVVLYEYLGEEYPEVLGSILGALKAIVNVIGM--HKMTPPIKDL------LPRLTPI-L 572 Query: 250 ASHVKNLDENGLDLLSKM 267 + + + EN +DL+ ++ Sbjct: 573 KNRHEKVQENCIDLVGRI 590 >5LJ3-H nrPDB Length = 591 Score = 28.7 bits (63), Expect = 3.1, Method: Composition-based stats. Identities = 16/66 (24%), Positives = 27/66 (40%), Gaps = 6/66 (9%) Query: 92 DSIPPGQYMDSSLVKSYLYQILQ--GIVFCHSRRVLHRDLKPQNLLIDDKGTIK-LADFG 148 D Q + +++S++ I+ + HRDL N+LI K + DF Sbjct: 8 DEDIKFQRENWEMIRSHVSPIISNLTMDNLQES---HRDLFQVNILIGRDIICKNVVDFT 64 Query: 149 LARAFG 154 L + G Sbjct: 65 LNKQNG 70 >2X8T-A nrPDB Length = 471 Score = 28.3 bits (62), Expect = 3.9, Method: Composition-based stats. Identities = 8/43 (18%), Positives = 19/43 (44%), Gaps = 2/43 (4%) Query: 59 RHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMD 101 +HPN+V +D +L+++ + S ++ + P Sbjct: 165 KHPNVVDPHTFFDKDGKLWMV--YGSYSGGIFILEMNPKTGFP 205 >5XGF-A nrPDB Length = 300 Score = 28.3 bits (62), Expect = 4.6, Method: Composition-based stats. Identities = 18/90 (20%), Positives = 35/90 (38%), Gaps = 9/90 (10%) Query: 30 VAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD-VLMQDSRLY-LIFEFLSMDL 87 A K ++ E+ +EI + K + + Q +++Y LIF L Sbjct: 174 YAEKVLQNVKEDNEKDEAKRQEILIAKTFNFYDYMLFQRLAFHSGNQIYGLIF----NGL 229 Query: 88 KKYLDSIPPGQYMDS---SLVKSYLYQILQ 114 KK D + + + L + +Q+L+ Sbjct: 230 KKLYDRVGSYYFSNPASRELALKFYHQLLE 259 >3G1Z-A nrPDB Length = 326 Score = 27.9 bits (61), Expect = 5.0, Method: Composition-based stats. Identities = 15/84 (17%), Positives = 32/84 (38%), Gaps = 3/84 (3%) Query: 203 LFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLAS---HVKNLDEN 259 L+ S + R+ A P ++ + + ++ P++ + L Sbjct: 72 LYLMTSPEYHMKRLLAAGCGPVFQLCRSFRNEEMGRHHNPEFTMLEWYRPHYDMYRLMNE 131 Query: 260 GLDLLSKMLIYDPAKRISGKMALN 283 DLL ++L PA+ +S + A Sbjct: 132 VDDLLQQVLDCQPAESLSYQQAFQ 155 >4BVU-A nrPDB Length = 211 Score = 27.9 bits (61), Expect = 5.3, Method: Composition-based stats. Identities = 24/149 (16%), Positives = 51/149 (34%), Gaps = 26/149 (17%) Query: 6 KIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEE-EGVPSTAIREISLLKELRHPNIV 64 + IG+G+ +++ + ++ KK L + + A +E L Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALY---KKYDLIGNQYNEILEMAWQESELFNA------- 93 Query: 65 SLQD-----VLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 119 V+ +YL + +D+ + ++ YL I + Sbjct: 94 -FYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTAD----IPDNIESLYLQLICK----L 144 Query: 120 HSRRVLHRDLKPQNLLIDDKGT-IKLADF 147 + ++H DL N+L D + + DF Sbjct: 145 NELSIIHYDLNTGNMLYDKESESLFPIDF 173 >5FBM-A nrPDB Length = 99 Score = 27.5 bits (60), Expect = 6.6, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 22/42 (52%), Gaps = 6/42 (14%) Query: 5 TKIEKIGEGTYGVVY-----KGRHKTTGQVVAMKKIRLESEE 41 K++ IG G + V KGR+ TG+ + +K ++ + + Sbjct: 41 EKVQLIGFGNF-EVRERAARKGRNPQTGEEIKIKASKVPAFK 81 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.314 0.155 0.487 Lambda K H 0.267 0.0467 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,390,497 Number of Sequences: 36641 Number of extensions: 567247 Number of successful extensions: 5872 Number of sequences better than 10.0: 516 Number of HSP's better than 10.0 without gapping: 939 Number of HSP's successfully gapped in prelim test: 56 Number of HSP's that attempted gapping in prelim test: 1697 Number of HSP's gapped (non-prelim): 1207 length of query: 297 length of database: 10,336,785 effective HSP length: 96 effective length of query: 201 effective length of database: 6,819,249 effective search space: 1370669049 effective search space used: 1370669049 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 59 (27.1 bits)