BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P06169 (563 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1QPB-A nrPDB 1161 0.0 6EFG-A nrPDB 997 0.0 2VBF-A nrPDB 361 e-100 1OVM-A nrPDB 358 4e-99 5NPU-A nrPDB 273 1e-73 2VBI-A nrPDB 257 1e-68 4COK-A nrPDB 241 8e-64 5EUJ-A nrPDB 235 3e-62 4ZP1-A nrPDB 224 9e-59 2Q5O-A nrPDB 162 3e-40 1T9B-A nrPDB 92 5e-19 5WJ1-A nrPDB 85 1e-16 6DEO-A nrPDB 79 4e-15 2PAN-A nrPDB 71 1e-12 6A50-A nrPDB 69 4e-12 2JI6-A nrPDB 68 9e-12 4Q9D-A nrPDB 68 1e-11 5AHK-A nrPDB 63 4e-10 4QQ8-A nrPDB 63 4e-10 5D6R-B nrPDB 62 6e-10 2EZ4-A nrPDB 60 2e-09 2PGN-A nrPDB 57 1e-08 2Q28-A nrPDB 49 8e-06 3EYA-A nrPDB 47 3e-05 4RJK-A nrPDB 40 0.002 1UPC-A nrPDB 38 0.010 1V5E-A nrPDB 31 1.6 6J5T-G nrPDB 30 3.1 >1QPB-A nrPDB Length = 563 Score = 1161 bits (3004), Expect = 0.0, Method: Compositional matrix adjust. Identities = 559/563 (99%), Positives = 561/563 (99%) Query: 1 MSEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADG 60 MSEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADG Sbjct: 1 MSEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADG 60 Query: 61 YARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNG 120 YARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNG Sbjct: 61 YARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNG 120 Query: 121 DFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKL 180 DFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKL Sbjct: 121 DFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKL 180 Query: 181 LQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQF 240 LQTPIDMSLKPNDAESEKEVIDTIL L+KDAKNPVILADACCSRHDVKAETKKLIDLTQF Sbjct: 181 LQTPIDMSLKPNDAESEKEVIDTILVLIKDAKNPVILADACCSRHDVKAETKKLIDLTQF 240 Query: 241 PAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYS 300 PAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYS Sbjct: 241 PAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYS 300 Query: 301 YKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANAAVP 360 YKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLT IADAAKGYKPVAVPARTPANAAVP Sbjct: 301 YKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTAIADAAKGYKPVAVPARTPANAAVP 360 Query: 361 ASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTG 420 ASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTG Sbjct: 361 ASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTG 420 Query: 421 ATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLI 480 ATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLI Sbjct: 421 ATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLI 480 Query: 481 HGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSFNDNSKIRMIEIML 540 HGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSFNDNSKIRMIE+ML Sbjct: 481 HGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSFNDNSKIRMIEVML 540 Query: 541 PVFDAPQNLVEQAKLTAATNAKQ 563 PVFDAPQNLVEQAKLTAATNAKQ Sbjct: 541 PVFDAPQNLVEQAKLTAATNAKQ 563 >6EFG-A nrPDB Length = 563 Score = 997 bits (2578), Expect = 0.0, Method: Compositional matrix adjust. Identities = 485/562 (86%), Positives = 519/562 (92%) Query: 1 MSEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADG 60 MSEITLG+YLFERLKQV V T+FGLPGDFNLSLLD IYEV GMRWAGNANELNAAYAADG Sbjct: 1 MSEITLGRYLFERLKQVEVQTIFGLPGDFNLSLLDNIYEVPGMRWAGNANELNAAYAADG 60 Query: 61 YARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNG 120 YAR+KGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPS+S+QAKQLLLHHTLGNG Sbjct: 61 YARLKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSVSSQAKQLLLHHTLGNG 120 Query: 121 DFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKL 180 DFTVFHRMS+NISETTAMITDI TAPAEIDRCIRTTYV+QRPVYLGLPANLVDL VPA L Sbjct: 121 DFTVFHRMSSNISETTAMITDINTAPAEIDRCIRTTYVSQRPVYLGLPANLVDLTVPASL 180 Query: 181 LQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQF 240 L TPID+SLKPND E+E+EVI+ +L L+K+AKNPVILADACCSRHD KAETKKLIDLTQF Sbjct: 181 LDTPIDLSLKPNDPEAEEEVIENVLQLIKEAKNPVILADACCSRHDAKAETKKLIDLTQF 240 Query: 241 PAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYS 300 PAFVTPMGKGSIDE+HPR+GGVYVGTLS P VKEAVESADL+LSVGALLSDFNTGSFSYS Sbjct: 241 PAFVTPMGKGSIDEKHPRFGGVYVGTLSSPAVKEAVESADLVLSVGALLSDFNTGSFSYS 300 Query: 301 YKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANAAVP 360 YKTKNIVEFHSD+ KIR+ATFPGVQMKF LQKLLT +ADAAKGYKPV VP+ N AV Sbjct: 301 YKTKNIVEFHSDYTKIRSATFPGVQMKFALQKLLTKVADAAKGYKPVPVPSEPEHNEAVA 360 Query: 361 ASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTG 420 STPLKQEW+W Q+G FL+EGDVVI ETGTSAFGINQT FPNNTYGISQVLWGSIGFTTG Sbjct: 361 DSTPLKQEWVWTQVGEFLREGDVVITETGTSAFGINQTHFPNNTYGISQVLWGSIGFTTG 420 Query: 421 ATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLI 480 ATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIE+LI Sbjct: 421 ATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIERLI 480 Query: 481 HGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSFNDNSKIRMIEIML 540 HG AQYN IQ W HL LLPTFGAKDYE RV+TTGEW+KLT D+ F DN++IR+IE+ML Sbjct: 481 HGETAQYNCIQNWQHLELLPTFGAKDYEAVRVSTTGEWNKLTTDEKFQDNTRIRLIEVML 540 Query: 541 PVFDAPQNLVEQAKLTAATNAK 562 P DAP NLV+QA+LTAATNAK Sbjct: 541 PTMDAPSNLVKQAQLTAATNAK 562 >2VBF-A nrPDB Length = 570 Score = 361 bits (926), Expect = e-100, Method: Compositional matrix adjust. Identities = 207/563 (36%), Positives = 312/563 (55%), Gaps = 20/563 (3%) Query: 2 SEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGY 61 S T+G YL +RL ++ + +FG+PGD+NL LD+I E M+W GNANELNA+Y ADGY Sbjct: 23 SMYTVGDYLLDRLHELGIEEIFGVPGDYNLQFLDQIISREDMKWIGNANELNASYMADGY 82 Query: 62 ARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGD 121 AR K + +TTFGVGELSA+NG+AGSYAE++ V+ +VG P+ Q +HHTL +GD Sbjct: 83 ARTKKAAAFLTTFGVGELSAINGLAGSYAENLPVVEIVGSPTSKVQNDGKFVHHTLADGD 142 Query: 122 FTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLL 181 F F +M ++ ++T A EIDR + ++PVY+ LP ++V A Sbjct: 143 FKHFMKMHEPVTAARTLLT-AENATYEIDRVLSQLLKERKPVYINLP-----VDVAAAKA 196 Query: 182 QTPIDMSLKPNDA---ESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLT 238 + P +SL+ + +E+ ++ I +K+A+ PV++A ++ + + T Sbjct: 197 EKPA-LSLEKESSTTNTTEQVILSKIEESLKNAQKPVVIAGHEVISFGLEKTVTQFVSET 255 Query: 239 QFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFS 298 + P GK ++DE P + G+Y G LS+ +K VESAD IL +G L+D +TG+F+ Sbjct: 256 KLPITTLNFGKSAVDESLPSFLGIYNGKLSEISLKNFVESADFILMLGVKLTDSSTGAFT 315 Query: 299 YSYKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANAA 358 + ++ + D I N + V+ L KG + Sbjct: 316 HHLDENKMISLNIDEGIIFNKVVEDFDFRAVVSSL-----SELKGIEYEGQYIDKQYEEF 370 Query: 359 VPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFT 418 +P+S PL Q+ +W + + Q + ++AE GTS FG + +N+ I Q LWGSIG+T Sbjct: 371 IPSSAPLSQDRLWQAVESLTQSNETIVAEQGTSFFGASTIFLKSNSRFIGQPLWGSIGYT 430 Query: 419 TGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEK 478 A LG+ A D + R +LFIGDGSLQLTVQE+ IR L P F++NNDGYT+E+ Sbjct: 431 FPAALGSQIA----DKESRHLLFIGDGSLQLTVQELGLSIREKLNPICFIINNDGYTVER 486 Query: 479 LIHGPKAQYNEIQGWDHLSLLPTFGA-KDYETHRVATTGEWDKLTQDKSFNDNSKIRMIE 537 IHGP YN+I W++ L TFGA +D ++ T ++ D +++ IE Sbjct: 487 EIHGPTQSYNDIPMWNYSKLPETFGATEDRVVSKIVRTENEFVSVMKEAQADVNRMYWIE 546 Query: 538 IMLPVFDAPQNLVEQAKLTAATN 560 ++L DAP+ L + KL A N Sbjct: 547 LVLEKEDAPKLLKKMGKLFAEQN 569 >1OVM-A nrPDB Length = 552 Score = 358 bits (919), Expect = 4e-99, Method: Compositional matrix adjust. Identities = 213/569 (37%), Positives = 309/569 (54%), Gaps = 37/569 (6%) Query: 5 TLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARI 64 + YL +RL + +FG+PGD+NL LD + + + W G ANELNA+YAADGYAR Sbjct: 6 CVADYLLDRLTDCGADHLFGVPGDYNLQFLDHVIDSPDICWVGCANELNASYAADGYARC 65 Query: 65 KGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTV 124 KG + ++TTFGVGELSA+NGIAGSYAEHV VLH+VG P +AQ + LLHHTLG+G+F Sbjct: 66 KGFAALLTTFGVGELSAMNGIAGSYAEHVPVLHIVGAPGTAAQQRGELLHHTLGDGEFRH 125 Query: 125 FHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLLQTP 184 F+ MS I+ A++T+ A EIDR + T +RP YL LPA++ AK TP Sbjct: 126 FYHMSEPITVAQAVLTE-QNACYEIDRVLTTMLRERRPGYLMLPADV------AKKAATP 178 Query: 185 IDMSLKPNDAESEKEVIDTILALVKD----AKNPVILADACCSRHDVKAETKKLIDLTQF 240 +L A ++ + ++ +K +LAD RH +K +K + Sbjct: 179 PVNALTHKQAHADSACLKAFRDAAENKLAMSKRTALLADFLVLRHGLKHALQKWVKEVPM 238 Query: 241 PAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYS 300 MGKG DE+ + G Y G+ S VKEA+E AD +L VG +D T F++ Sbjct: 239 AHATMLMGKGIFDERQAGFYGTYSGSASTGAVKEAIEGADTVLCVGTRFTDTLTAGFTHQ 298 Query: 301 YKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANAAVP 360 +E ++ + F G+ M + + T+ + K + V + ++ A+P Sbjct: 299 LTPAQTIEVQPHAARVGDVWFTGIPMN----QAIETLVELCKQH--VHAGLMSSSSGAIP 352 Query: 361 ASTP---LKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGF 417 P L QE W L F++ GD+++A+ GTSAFG P + I Q LWGSIG+ Sbjct: 353 FPQPDGSLTQENFWRTLQTFIRPGDIILADQGTSAFGAIDLRLPADVNFIVQPLWGSIGY 412 Query: 418 TTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIE 477 TL AAF A+ P +RVI+ GDG+ QLT+QE+ +M+R P + VLNN+GYT+E Sbjct: 413 ----TLAAAFGAQTACPNRRVIVLTGDGAAQLTIQELGSMLRDKQHPIILVLNNEGYTVE 468 Query: 478 KLIHGPKAQYNEIQGWD------HLSLLPTFGAKDYETHRVATTGEWDKLTQDKSFNDNS 531 + IHG + +YN+I W+ LSL P E RV+ + + + + ++ Sbjct: 469 RAIHGAEQRYNDIALWNWTHIPQALSLDP-----QSECWRVSEAEQLADVLEKVAHHE-- 521 Query: 532 KIRMIEIMLPVFDAPQNLVEQAKLTAATN 560 ++ +IE+MLP D P L K A N Sbjct: 522 RLSLIEVMLPKADIPPLLGALTKALEACN 550 >5NPU-A nrPDB Length = 563 Score = 273 bits (698), Expect = 1e-73, Method: Compositional matrix adjust. Identities = 180/567 (31%), Positives = 273/567 (48%), Gaps = 21/567 (3%) Query: 5 TLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARI 64 T+G YL RL Q+ + F + GD+NL LLD++ + + + NELN ++A+GYAR Sbjct: 4 TVGHYLATRLAQIGLKHHFAVAGDYNLVLLDQLLKNKDLEQVYCCNELNCGFSAEGYARA 63 Query: 65 KGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTV 124 G+ + TF VG LSA N I G+YAE++ V+ + G P+ + +LHHT+G D+ Sbjct: 64 NGVGAAVVTFSVGALSAFNAIGGAYAENLPVILISGAPNTNDHGSGHILHHTIGTTDYGY 123 Query: 125 FHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLLQTP 184 M+ I+ IT APA ID IRT ++P Y+ + NV A+ P Sbjct: 124 QLEMAKQITCAAVSITHAEDAPALIDHAIRTALREKKPAYIE-----IACNVAAQPCARP 178 Query: 185 IDMSLKPN----DAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQF 240 +S N D E+ K ++ L ++ + PV+L + +L D Sbjct: 179 GPVSALLNEPTSDEETLKAAVEAALDFIEKREKPVLLVGGKLRAAGAEEAVVELADALGC 238 Query: 241 PAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYS 300 K E HP Y G Y G +S P V+E V+ AD I+ +G + +D++T ++ Sbjct: 239 AVATMAAAKSFFPEDHPGYVGTYWGEVSSPGVEEIVDWADGIICLGPVFNDYSTVGWTAW 298 Query: 301 YKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANAAVP 360 K +N+V H+ + F G+ +K L L + PA VP Sbjct: 299 PKGENVVLVDPHHITVGGEEFTGIHLKDFLTALTERVPKKDATLDQFKARVGKPAAEKVP 358 Query: 361 AS---TPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGF 417 A+ PL + + Q+ L +IAETG S F + P+ ++ WG IG+ Sbjct: 359 AADPNAPLTRAELCRQIQGLLNPNTTLIAETGDSWFNAMRMKLPHGARVELEMQWGHIGW 418 Query: 418 TTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIE 477 + AT G A A +P++R +L +GDGS QLT QE++ M+R L +F++NN GYTIE Sbjct: 419 SVPATFGYAVA----EPERRNVLMVGDGSFQLTAQEVAQMVRRKLPIIIFLINNRGYTIE 474 Query: 478 KLIH-GPKAQYNEIQGWDHLSLLPTFGAKDYETHRV-ATTGEWDKLTQDKSFNDNSKIRM 535 IH GP YN I+ WD+ L+ F A+D + + ATTG K+ + Sbjct: 475 VKIHDGP---YNNIKNWDYAGLMEVFNAEDGKGLGLKATTGGELAEAIKKALAHREGPTL 531 Query: 536 IEIMLPVFDAPQNLVEQAKLTAATNAK 562 IE ++ D LV K A NA+ Sbjct: 532 IECVIDRDDCTPELVTWGKKVATANAR 558 >2VBI-A nrPDB Length = 566 Score = 257 bits (656), Expect = 1e-68, Method: Compositional matrix adjust. Identities = 172/570 (30%), Positives = 283/570 (49%), Gaps = 30/570 (5%) Query: 5 TLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARI 64 T+G YL ERL Q+ + F + GD+NL LLD++ + M+ NELN ++A+GYAR Sbjct: 4 TVGMYLAERLVQIGLKHHFAVAGDYNLVLLDQLLLNKDMKQIYCCNELNCGFSAEGYARS 63 Query: 65 KGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTV 124 G + + TF VG +SA+N + G+YAE++ V+ + G P+ + Q +LHHT+G D++ Sbjct: 64 NGAAAAVVTFSVGAISAMNALGGAYAENLPVILISGAPNSNDQGTGHILHHTIGKTDYSY 123 Query: 125 FHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANL-----VDLNVPAK 179 M+ ++ ITD +APA+ID IRT ++P YL + N+ V + Sbjct: 124 QLEMARQVTCAAESITDAHSAPAKIDHVIRTALRERKPAYLDIACNIASEPCVRPGPVSS 183 Query: 180 LLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQ 239 LL P D S K +D +AL++ + +PV+L + + A T+ L D Q Sbjct: 184 LLSEP------EIDHTSLKAAVDATVALLEKSASPVMLLGSKLRAANALAATETLADKLQ 237 Query: 240 FPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSY 299 + KG E H + G+Y G +S P V+E VE++D +L + + +D++T +S Sbjct: 238 CAVTIMAAAKGFFPEDHAGFRGLYWGEVSNPGVQELVETSDALLCIAPVFNDYSTVGWSA 297 Query: 300 SYKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANAAV 359 K N++ D + + + G F L+ L +A+ A A + P + Sbjct: 298 WPKGPNVILAEPDRVTVDGRAYDG----FTLRAFLQALAEKAPARPASAQKSSVPTCSLT 353 Query: 360 PAS--TPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGF 417 S L + + + L ++AETG S F + T P ++ WG IG+ Sbjct: 354 ATSDEAGLTNDEIVRHINALLTSNTTLVAETGDSWFNAMRMTLPRGARVELEMQWGHIGW 413 Query: 418 TTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIE 477 + + G A +++ ++ ++ +GDGS QLT QE++ M+R+ L +F++NN GY IE Sbjct: 414 SVPSAFGNAMGSQD----RQHVVMVGDGSFQLTAQEVAQMVRYELPVIIFLINNRGYVIE 469 Query: 478 KLIH-GPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSFNDNSKIR-- 534 IH GP YN I+ WD+ L+ F A E H + K + + R Sbjct: 470 IAIHDGP---YNYIKNWDYAGLMEVFNAG--EGHGLGLKATTPKELTEAIARAKANTRGP 524 Query: 535 -MIEIMLPVFDAPQNLVEQAKLTAATNAKQ 563 +IE + D LV+ + A+TNA++ Sbjct: 525 TLIECQIDRTDCTDMLVQWGRKVASTNARK 554 >4COK-A nrPDB Length = 558 Score = 241 bits (614), Expect = 8e-64, Method: Compositional matrix adjust. Identities = 180/556 (32%), Positives = 269/556 (48%), Gaps = 20/556 (3%) Query: 5 TLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARI 64 T+G+YL +RL Q+ + F + GD+NL LLD++ M+ +NELN ++A+GYAR Sbjct: 4 TVGRYLADRLAQIGLKHHFAVAGDYNLVLLDQLLLNTDMQQIYCSNELNCGFSAEGYARA 63 Query: 65 KGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTV 124 G + I TF VG LSA N + G+YAE++ V+ + G P+ + +LHHTLG D+ Sbjct: 64 NGAAAAIVTFSVGALSAFNALGGAYAENLPVILISGAPNANDHGTGHILHHTLGTTDYGY 123 Query: 125 FHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLLQTP 184 M+ +I+ I APA+ID IRT ++P YL + N+ P + Sbjct: 124 QLEMARHITCAAESIVAAEDAPAKIDHVIRTALREKKPAYLEIACNVA--GAPC-VRPGG 180 Query: 185 IDMSLKP--NDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFPA 242 ID L P D S K +D LA ++ + +L + +A+ L D Sbjct: 181 IDALLSPPAPDEASLKAAVDAALAFIEQRGSVTMLVGSRIRAAGAQAQAVALADALGCAV 240 Query: 243 FVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYSYK 302 K E HP Y G Y G +S P ++AVE AD ++ + + +D+ T +S K Sbjct: 241 TTMAAAKSFFPEDHPGYRGHYWGEVSSPGAQQAVEGADGVICLAPVFNDYATVGWSAWPK 300 Query: 303 TKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLT-TIADAAKGYKPVAVPARTPANAAVPA 361 N++ + + + G+ M+ L +L T+ A V +TPA A Sbjct: 301 GDNVMLVERHAVTVGGVAYAGIDMRDFLTRLAAHTVRRDATARGGAYVTPQTPAAA---P 357 Query: 362 STPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTGA 421 + PL M Q+G L + AETG S F + P+ ++ WG IG++ A Sbjct: 358 TAPLNNAEMARQIGALLTPRTTLTAETGDSWFNAVRMKLPHGARVELEMQWGHIGWSVPA 417 Query: 422 TLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLIH 481 G A AA P+++ +L +GDGS QLT QE++ MIR L +F++NN GYTIE +IH Sbjct: 418 AFGNALAA----PERQHVLMVGDGSFQLTAQEVAQMIRHDLPVIIFLINNHGYTIEVMIH 473 Query: 482 -GPKAQYNEIQGWDHLSLLPTFGAKDYE--THRVATTGEWDKLTQDKSFNDNSKIRMIEI 538 GP YN ++ WD+ L+ F A + R T GE + N N +IE Sbjct: 474 DGP---YNNVKNWDYAGLMEVFNAGEGNGLGLRARTGGELAAAIEQARANRNGPT-LIEC 529 Query: 539 MLPVFDAPQNLVEQAK 554 L D Q LV K Sbjct: 530 TLDRDDCTQELVTWGK 545 >5EUJ-A nrPDB Length = 573 Score = 235 bits (600), Expect = 3e-62, Method: Compositional matrix adjust. Identities = 169/568 (29%), Positives = 278/568 (48%), Gaps = 26/568 (4%) Query: 5 TLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARI 64 T+G YL ERL Q+ + F + GD+NL LLD++ + M NELN ++A+GYAR Sbjct: 3 TVGMYLAERLAQIGLKHHFAVAGDYNLVLLDQLLLNKDMEQVYCCNELNCGFSAEGYARA 62 Query: 65 KGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTV 124 +G + I TF VG +SA+N I G+YAE++ V+ + G P+ + +LHHT+G D+ Sbjct: 63 RGAAAAIVTFSVGAISAMNAIGGAYAENLPVILISGSPNTNDYGTGHILHHTIGTTDYNY 122 Query: 125 FHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLLQTP 184 M +++ I APA+ID IRT ++P YL + N+ + P Sbjct: 123 QLEMVKHVTCAAESIVSAEEAPAKIDHVIRTALRERKPAYLEIACNVAGAEC---VRPGP 179 Query: 185 IDMSLK--PNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFPA 242 I+ L+ D S +D + ++D +N V+L + + + L D Sbjct: 180 INSLLRELEVDQTSVTAAVDAAVEWLQDRQNVVMLVGSKLRAAAAEKQAVALADRLGCAV 239 Query: 243 FVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYSYK 302 + KG E HP + G+Y G +S +E VE+AD IL + + +D+ T ++ K Sbjct: 240 TIMAAAKGFFPEDHPNFRGLYWGEVSSEGAQELVENADAILCLAPVFNDYATVGWNSWPK 299 Query: 303 TKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPA---NAAV 359 N++ +D + +F G+ L +A+ A + P AA Sbjct: 300 GDNVMVMDTDRVTFAGQSFEGLS----LSTFAAALAEKAPSRPATTQGTQAPVLGIEAAE 355 Query: 360 PASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTT 419 P + PL + M Q+ + + + AETG S F ++ P ++ WG IG++ Sbjct: 356 P-NAPLTNDEMTRQIQSLITSDTTLTAETGDSWFNASRMPIPGGARVELEMQWGHIGWSV 414 Query: 420 GATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKL 479 + G A + P++R I+ +GDGS QLT QE++ MIR+ + +F++NN GY IE Sbjct: 415 PSAFGNAVGS----PERRHIMMVGDGSFQLTAQEVAQMIRYEIPVIIFLINNRGYVIEIA 470 Query: 480 IH-GPKAQYNEIQGWDHLSLLPTFGAKDYETHRV---ATTGEWDKLTQDKSFNDNSKIRM 535 IH GP YN I+ W++ L+ F D + H + A+TG + K+ ++ + Sbjct: 471 IHDGP---YNYIKNWNYAGLIDVF--NDEDGHGLGLKASTGAELEGAIKKALDNRRGPTL 525 Query: 536 IEIMLPVFDAPQNLVEQAKLTAATNAKQ 563 IE + D + L+ K AATN+++ Sbjct: 526 IECNIAQDDCTETLIAWGKRVAATNSRK 553 >4ZP1-A nrPDB Length = 568 Score = 224 bits (570), Expect = 9e-59, Method: Compositional matrix adjust. Identities = 170/569 (29%), Positives = 273/569 (47%), Gaps = 20/569 (3%) Query: 5 TLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARI 64 T+G YL ERL Q+ + F + GD+NL LLD + + M NELN ++A+GYAR Sbjct: 4 TVGTYLAERLVQIGLKHHFAVAGDYNLVLLDNLLLNKNMEQVYCCNELNCGFSAEGYARA 63 Query: 65 KGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTV 124 KG + + T+ VG LSA + I G+YAE++ V+ + G P+ + A +LHH LG D+ Sbjct: 64 KGAAAAVVTYSVGALSAFDAIGGAYAENLPVILISGAPNNNDHAAGHVLHHALGKTDYHY 123 Query: 125 FHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLLQTP 184 M+ NI+ I APA+ID I+T ++PVYL + N+ + A + Sbjct: 124 QLEMAKNITAAAEAIYTPEEAPAKIDHVIKTALREKKPVYLEIACNIASMPCAAPGPASA 183 Query: 185 IDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFPAFV 244 + + + +D S ++ L + + +L + + K D Sbjct: 184 L-FNDEASDEASLNAAVEETLKFIANRDKVAVLVGSKLRAAGAEEAAVKFADALGGAVAT 242 Query: 245 TPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYSYKTK 304 K E++P Y G G +S P V++ ++ AD ++++ + +D++T ++ K Sbjct: 243 MAAAKSFFPEENPHYIGTSWGEVSYPGVEKTMKEADAVIALAPVFNDYSTTGWTDIPDPK 302 Query: 305 NIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIAD---AAKGYKPVAVPARTPANAAVPA 361 +V + + FP V +K L +L ++ A +K + A A P Sbjct: 303 KLVLAEPRSVVVNGIRFPSVHLKDYLTRLAQKVSKKTGALDFFKSLNAGELKKAAPADP- 361 Query: 362 STPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTGA 421 S PL + Q+ L VIAETG S F + PN ++ WG IG++ A Sbjct: 362 SAPLVNAEIARQVEALLTPNTTVIAETGDSWFNAQRMKLPNGARVEYEMQWGHIGWSVPA 421 Query: 422 TLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLIH 481 G A A P++R IL +GDGS QLT QE++ M+R L +F++NN GYTI +IH Sbjct: 422 AFGYAVGA----PERRNILMVGDGSFQLTAQEVAQMVRLKLPVIIFLINNYGYTIAVMIH 477 Query: 482 -GPKAQYNEIQGWDHLSLLPTF-GAKDYETH-----RVATTGEWDKLTQDKSFNDNSKIR 534 GP YN I+ WD+ L+ F G Y++ + T GE + + N + Sbjct: 478 DGP---YNNIKNWDYAGLMEVFNGNGGYDSGAGKGLKAKTGGELAEAIKVALANTDGPT- 533 Query: 535 MIEIMLPVFDAPQNLVEQAKLTAATNAKQ 563 +IE + D + LV+ K AA N+++ Sbjct: 534 LIECFIGREDCTEELVKWGKRVAAANSRK 562 >2Q5O-A nrPDB Length = 565 Score = 162 bits (411), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 142/548 (25%), Positives = 238/548 (43%), Gaps = 33/548 (6%) Query: 2 SEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGY 61 S + L + L LK +FG+PGDF L E + + ++E +AAD Sbjct: 19 SHMKLAEALLRALKDRGAQAMFGIPGDFALPFFKVAEETQILPLHTLSHEPAVGFAADAA 78 Query: 62 ARIKG-MSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNG 120 AR + T+G G + +N +AG+YAE V+ + G P + LLLHH Sbjct: 79 ARYSSTLGVAAVTYGAGAFNMVNAVAGAYAEKSPVVVISGAPGTTEGNAGLLLHHQGRTL 138 Query: 121 D--FTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPA 178 D F VF I+ A + D A APAEI R + RPVYL +P N+V+ V Sbjct: 139 DTQFQVFK----EITVAQARLDDPAKAPAEIARVLGAARAQSRPVYLEIPRNMVNAEV-- 192 Query: 179 KLLQTPI-DMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDL 237 P+ D P D ++ D +LA ++ A +PV++ R+ ++A+ +L Sbjct: 193 ----EPVGDDPAWPVDRDALAACADEVLAAMRSATSPVLMVCVEVRRYGLEAKVAELAQR 248 Query: 238 TQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSF 297 P T MG+G + + G Y+G E+ VE +D + +GA+LSD N Sbjct: 249 LGVPVVTTFMGRGLLADAPTPPLGTYIGVAGDAEITRLVEESDGLFLLGAILSDTNFAVS 308 Query: 298 SYSYKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADA---AKGYKPVAVPARTP 354 + + + + T+ + + ++ LL + + +G +P A P Sbjct: 309 QRKIDLRKTIHAFDRAVTLGYHTYADIPLAGLVDALLERLPPSDRTTRGKEPHAYPTGLQ 368 Query: 355 ANAAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGI-SQVLWG 413 A+ A P+ N QE ++ A+ G F T G+ + + Sbjct: 369 ADGEPIA--PMDIARAVNDRVRAGQEPLLIAADMGDCLF----TAMDMIDAGLMAPGYYA 422 Query: 414 SIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDG 473 +GF A +G A+ + KR++ +GDG+ Q+T E+ R G+ P + + NN Sbjct: 423 GMGFGVPAGIG----AQCVSGGKRILTVVGDGAFQMTGWELGNCRRLGIDPIVILFNNAS 478 Query: 474 YTIEKLIHGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSFNDNSKI 533 + + + P++ +N++ W + G + RV T E K DK+F + Sbjct: 479 WEMLRTFQ-PESAFNDLDDWRFADMAAGMGG---DGVRVRTRAEL-KAALDKAFATRGRF 533 Query: 534 RMIEIMLP 541 ++IE M+P Sbjct: 534 QLIEAMIP 541 >1T9B-A nrPDB Length = 677 Score = 92.4 bits (228), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 126/512 (24%), Positives = 207/512 (40%), Gaps = 68/512 (13%) Query: 4 ITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYAR 63 +T G+ E + + NV+TVFG PG L + D I+ + + +E A + A+GYAR Sbjct: 82 LTGGQIFNEMMSRQNVDTVFGYPGGAILPVYDAIHNSDKFNFVLPKHEQGAGHMAEGYAR 141 Query: 64 IKGM-SCIITTFGVGELSALNGIAGSYAEHVGVLHVVG-VPSISAQAKQLLLHHTLGNGD 121 G ++ T G G + + +A ++A+ + ++ G VP+ + +G Sbjct: 142 ASGKPGVVLVTSGPGATNVVTPMADAFADGIPMVVFTGQVPTSAIGTDAFQEADVVG--- 198 Query: 122 FTVFHRMSANISETTAMITDIATAPAEIDRCIR-TTYVTQRPVYLGLPANLVDLNVPAKL 180 +S + ++ M+ + P I+ T PV + LP +V A + Sbjct: 199 ------ISRSCTKWNVMVKSVEELPLRINEAFEIATSGRPGPVLVDLPK-----DVTAAI 247 Query: 181 LQTPIDMSLK-PNDA----------ESEKEVIDTILALVKDAKNPVILADACCSRH-DVK 228 L+ PI P++A E + I+ L+ AK PV+ A H D Sbjct: 248 LRNPIPTKTTLPSNALNQLTSRAQDEFVMQSINKAADLINLAKKPVLYVGAGILNHADGP 307 Query: 229 AETKKLIDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGAL 288 K+L D Q P T G GS D++ P+ + +G AV++ADLI++VGA Sbjct: 308 RLLKELSDRAQIPVTTTLQGLGSFDQEDPKSLDM-LGMHGCATANLAVQNADLIIAVGAR 366 Query: 289 LSDFNTGSFS-------------------YSYKTKNIVEFHSDHMKIRN--ATFPGVQMK 327 D TG+ S + KNI + + + T G M Sbjct: 367 FDDRVTGNISKFAPEARRAAAEGRGGIIHFEVSPKNINKVVQTQIAVEGDATTNLGKMMS 426 Query: 328 --FVLQKLLTTIADAAKGYK--PVAVPARTPANAAVPASTPLKQEWMWNQLGNFLQEGDV 383 F +++ A K K P A TP + P + K + N G Sbjct: 427 KIFPVKERSEWFAQINKWKKEYPYAYMEETPGSKIKPQTVIKKLSKVANDTGRH------ 480 Query: 384 VIAETGTSA---FGINQTTFPNNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVIL 440 VI TG + T+ N I+ G++G+ A +GA A P+ VI Sbjct: 481 VIVTTGVGQHQMWAAQHWTWRNPHTFITSGGLGTMGYGLPAAIGAQVAK----PESLVID 536 Query: 441 FIGDGSLQLTVQEISTMIRWGLKPYLFVLNND 472 GD S +T+ E+S+ ++ G + +LNN+ Sbjct: 537 IDGDASFNMTLTELSSAVQAGTPVKILILNNE 568 >5WJ1-A nrPDB Length = 590 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 124/488 (25%), Positives = 204/488 (41%), Gaps = 51/488 (10%) Query: 10 LFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARIKGMSC 69 L E L++ V TVF PG ++ + + +R +E +AA+GYAR G Sbjct: 18 LVEALERQGVETVFAYPGGASMEIHQALTRSSSIRNVLPRHEQGGVFAAEGYARSSGKPG 77 Query: 70 I-ITTFGVGELSALNGIAGSYAEHVGVLHVVG-VPSISAQAKQLLLHHTLGNGDF--TVF 125 I I T G G + ++G+A + + V ++ + G VP +G F T Sbjct: 78 ICIATSGPGATNLVSGLADALLDSVPLVAITGQVP-----------RRMIGTDAFQETPI 126 Query: 126 HRMSANISETTAMITDIATAPAEIDRC-IRTTYVTQRPVYLGLPANL-VDLNVP--AKLL 181 ++ +I++ ++ D+ P I+ T PV + +P ++ L +P + + Sbjct: 127 VEVTRSITKHNYLVMDVEDIPRIIEEAFFLATSGRPGPVLVDVPKDIQQQLAIPNWEQAM 186 Query: 182 QTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVI-LADACCSRHDVKAETKKLIDLTQF 240 + P MS P E ++ I+ L+ ++K PV+ + C + D E + ++LT Sbjct: 187 RLPGYMSRMPKPPEDSH--LEQIVRLISESKKPVLYVGGGCLNSSD---ELGRFVELTGI 241 Query: 241 PAFVTPMGKGSI---DEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSF 297 P T MG GS DE G++ GT+ AVE +DL+L+ G D TG Sbjct: 242 PVASTLMGLGSYPCDDELSLHMLGMH-GTVY---ANYAVEHSDLLLAFGVRFDDRVTGKL 297 Query: 298 SYSYKTKNIVEFHSDHMKIRNATFPGVQ----MKFVLQKLLTTIADAAKGYKPVAVPART 353 IV D +I P V +K LQ + + + A+ K R Sbjct: 298 EAFASRAKIVHIDIDSAEIGKNKTPHVSVCGDVKLALQGMNKVLENRAEELKLDFGVWRN 357 Query: 354 PANA---AVPASTPLKQEWMWNQLG----NFLQEGDVVIAETGTSAFGINQTTFPNNTYG 406 N P S E + Q + L +G +I+ TG + F N Sbjct: 358 ELNVQKQKFPLSFKTFGEAIPPQYAIKVLDELTDGKAIIS-TGVGQHQMWAAQFYNYKKP 416 Query: 407 ---ISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLK 463 +S G++GF A +GA+ A +P V+ GDGS + VQE++T+ L Sbjct: 417 RQWLSSGGLGAMGFGLPAAIGASVA----NPDAIVVDIDGDGSFIMNVQELATIRVENLP 472 Query: 464 PYLFVLNN 471 + +LNN Sbjct: 473 VKVLLLNN 480 >6DEO-A nrPDB Length = 682 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 122/511 (23%), Positives = 207/511 (40%), Gaps = 66/511 (12%) Query: 4 ITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYAR 63 +T G+ E + + V+TVFG G L + D IY + ++ +E A + A+GYAR Sbjct: 87 LTGGEIFHEMMLRHKVDTVFGYAGGAILPVFDAIYNSDKFKFVLPRHEQGAGHMAEGYAR 146 Query: 64 IKGM-SCIITTFGVGELSALNGIAGSYAEHVGVLHVVG-VPSISAQAKQLLLHHTLGNGD 121 G ++ T G G + + +A + + V ++ G VP+ + +G Sbjct: 147 ASGKPGVVLVTSGPGATNVITPMADALMDGVPLVVFSGQVPTTAIGTDAFQEADIVG--- 203 Query: 122 FTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDL--NVPAK 179 +S + ++ M+ ++A P I+ T RP + LVDL +V A Sbjct: 204 ------ISRSCTKWNVMVKNVAELPRRINEAFEIA-TTGRPGPV-----LVDLPKDVTAS 251 Query: 180 LLQT--PIDMSLKPND---------AESEKEVIDTILALVKDAKNPVILADACCSRHDVK 228 +L+ PI+ +L N +E E I ++ AK P+I A A ++ Sbjct: 252 ILRESIPINTTLPSNALSQITKKAVSEFTSEAIKRAANILNKAKKPIIYAGAGILNNEQG 311 Query: 229 AE-TKKLIDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGA 287 + K+L D P T G G+ D++ P+ + +G A+++AD I+++GA Sbjct: 312 PKLLKELADKANIPVTTTLQGLGAFDQRDPKSLDM-LGMHGSAAANTAIQNADCIIALGA 370 Query: 288 LLSDFNTGSFS-------------------YSYKTKNIVEFHSDHMKIRNATFPGVQMKF 328 D TG+ S + KNI + I +Q Sbjct: 371 RFDDRVTGNISKFAPEAKLAASEGRGGILHFEISPKNINKVVEATEAIEGDVTANLQSFI 430 Query: 329 VL-------QKLLTTIADAAKGYKPVAVPARTPANAAVPASTPLKQEWMWNQLGNFLQEG 381 L + I + K Y P + TP + P T +K+ + +Q + +E Sbjct: 431 PLVDSIENRPEWFNKINEWKKKY-PYSYQLETPGSLIKP-QTLIKE--ISDQAQTYNKE- 485 Query: 382 DVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILF 441 VI TG + T + + G +G T G L AA A+ P VI Sbjct: 486 --VIVTTGVGQHQMWAAQHFTWTQPRTMITSGGLG-TMGYGLPAAIGAQVAKPDAIVIDI 542 Query: 442 IGDGSLQLTVQEISTMIRWGLKPYLFVLNND 472 GD S +T+ E+S+ ++ G + VLNN+ Sbjct: 543 DGDASFNMTLTELSSAVQAGAPIKVCVLNNE 573 >2PAN-A nrPDB Length = 616 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 103/488 (21%), Positives = 195/488 (39%), Gaps = 53/488 (10%) Query: 14 LKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARIKG--MSCII 71 L++ + T FG+PG + + G+R + A++ A+GY R + + Sbjct: 37 LEKEGITTAFGVPGAAINPFYSAMRKHGGIRHILARHVEGASHMAEGYTRATAGNIGVCL 96 Query: 72 TTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTV--FHRMS 129 T G + + + A+ + +L + G QA + LH DF ++ Sbjct: 97 GTSGPAGTDMITALYSASADSIPILCITG------QAPRARLHKE----DFQAVDIEAIA 146 Query: 130 ANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPAN-LVDLNVPAKLLQTPIDMS 188 +S+ + + A P R ++ + R G P LVDL ++ + D Sbjct: 147 KPVSKMAVTVREAALVP----RVLQQAFHLMRS---GRPGPVLVDLPFDVQVAEIEFDPD 199 Query: 189 L-------KPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFP 241 + KP A S ++ + L++ A+ PVI+A D A ++ +LT P Sbjct: 200 MYEPLPVYKP--AASRMQIEKAVEMLIQ-AERPVIVAGGGVINADAAALLQQFAELTSVP 256 Query: 242 AFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEA-VESADLILSVGALLSDFNTGSFSYS 300 T MG G I + H G+ VG + A + ++D++ +G ++ +TGS Sbjct: 257 VIPTLMGWGCIPDDHELMAGM-VGLQTAHRYGNATLLASDMVFGIGNRFANRHTGSVEKY 315 Query: 301 YKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVA-VPARTPANAAV 359 + + IV + +I P + + + LT + + A+ + +P R A Sbjct: 316 TEGRKIVHIDIEPTQIGRVLCPDLGIVSDAKAALTLLVEVAQEMQKAGRLPCRKEWVADC 375 Query: 360 PA------------STPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFP-NNTYG 406 + P+K + ++ ++ + G S Q + + Sbjct: 376 QQRKRTLLRKTHFDNVPVKPQRVYEEMNKAFGRDVCYVTTIGLSQIAAAQMLHVFKDRHW 435 Query: 407 ISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYL 466 I+ G +G+T A LG A DPK+ V+ GD Q ++E++ ++ + PY+ Sbjct: 436 INCGQAGPLGWTIPAALGVCAA----DPKRNVVAISGDFDFQFLIEELAVGAQFNI-PYI 490 Query: 467 FVLNNDGY 474 VL N+ Y Sbjct: 491 HVLVNNAY 498 >6A50-A nrPDB Length = 549 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 104/512 (20%), Positives = 199/512 (38%), Gaps = 44/512 (8%) Query: 11 FERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARIKGMSCI 70 +E L++ ++TVFG PG L L E R+ E ADGYA+ Sbjct: 30 YELLRRQGIDTVFGNPGSNELPFLKDF--PEDFRYILALQEACVVGIADGYAQASRKPAF 87 Query: 71 ITTF-GVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLG--NGDFTVFHR 127 I G +A+ ++ + H ++ G Q + ++ G N D R Sbjct: 88 INLHSAAGTGNAMGALSNARTSHSPLIVTAG------QQTRAMIGVEAGETNVDAANLPR 141 Query: 128 MSANISETTAMITDIATAPAEIDRCIR-TTYVTQRPVYLGLPANLVDLNVPAK---LLQT 183 S A ++ P + R I + Q PVYL +P + D + + L Sbjct: 142 PLVKWSYEPASAAEV---PHAMSRAIHMASMAPQGPVYLSVPYDDWDKDADPQSHHLFDR 198 Query: 184 PIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFPAF 243 + S++ ND + +D ++ + A NP I+ + A+ L + + P + Sbjct: 199 HVSSSVRLNDQD-----LDILVKALNSASNPAIVLGPDVDAANANADCVMLAERLKAPVW 253 Query: 244 VTPMG-KGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDF---NTGSFSY 299 V P + +HP + G+ ++ + + +E D++L +GA + + + G Y Sbjct: 254 VAPSAPRCPFPTRHPCFRGLMPAGIAA--ISQLLEGHDVVLVIGAPVFRYVFYDPGQ--Y 309 Query: 300 SYKTKNIVEFHSDHMKIRNATFPGVQMKFV--LQKLLTTIADAAKGYKPVAVPARTPANA 357 ++ D ++ A + + + L + + + P A P PA Sbjct: 310 LKPGTRLISVTCDPLEAARAPMGDAIVADIGAMASALANLVEESSRQLPTAAP--EPAKV 367 Query: 358 AVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGF 417 A L E +++ L + E + + E+ ++ + Q N G +GF Sbjct: 368 DQDAGR-LHPETVFDTLNDMAPENAIYLNESTSTTAQMWQRLNMRNPGSYYFCAAGGLGF 426 Query: 418 TTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIE 477 A +G A +P+++VI IGDGS ++ + T ++ + ++NN Y + Sbjct: 427 ALPAAIGVQLA----EPERQVIAVIGDGSANYSISALWTAAQYNIPTIFVIMNNGTYGML 482 Query: 478 KLIHGPKAQYN----EIQGWDHLSLLPTFGAK 505 + G N ++ G D +L +G + Sbjct: 483 RWFAGVLEAENVPGLDVPGIDFRALAKGYGVQ 514 >2JI6-A nrPDB Length = 568 Score = 68.2 bits (165), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 120/507 (23%), Positives = 204/507 (40%), Gaps = 69/507 (13%) Query: 3 EITLGKY-LFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGY 61 E+T G + L + LK +++T++G+ G ++ L ++++ +G R+ +E +A YAA Sbjct: 8 ELTDGFHVLIDALKMNDIDTMYGVVG-IPITNLARMWQDDGQRFYSFRHEQHAGYAASIA 66 Query: 62 ARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGD 121 I+G + T V LNG+ ++ +S +++ ++ L GD Sbjct: 67 GYIEGKPGVCLT--VSAPGFLNGVTSLAHATTNCFPMI---LLSGSSEREIVD--LQQGD 119 Query: 122 FTVFHRMSANISETTA--MITDIATAPAEIDRCIRTTYVTQRP--VYLGLPANL----VD 173 + +M+ A I I P I R +RT V+ RP VY+ LPA L + Sbjct: 120 YEEMDQMNVARPHCKASFRINSIKDIPIGIARAVRTA-VSGRPGGVYVDLPAKLFGQTIS 178 Query: 174 LNVPAKLLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKK 233 + KLL PID + AE + I L+K+AK PVI+ + E + Sbjct: 179 VEEANKLLFKPIDPAPAQIPAE---DAIARAADLIKNAKRPVIMLGKGAAYAQCDDEIRA 235 Query: 234 LIDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGA----LL 289 L++ T P M KG + + HP+ + A+ D+ + +GA L+ Sbjct: 236 LVEETGIPFLPMGMAKGLLPDNHPQS--------AAATRAFALAQCDVCVLIGARLNWLM 287 Query: 290 SDFNTGSFSYSYKTKNIVEFHSDHMKIRNATFPGV--QMKFVLQKLLTTIADAAKGYKP- 346 ++ K ++ ++ M V +K + L + A K Sbjct: 288 QHGKGKTWGDELKKYVQIDIQANEMDSNQPIAAPVVGDIKSAVSLLRKALKGAPKADAEW 347 Query: 347 -VAVPARTPANAA-----VPASTPLKQEWMWNQLG---NF-LQEGDVVIAETGTSAFGIN 396 A+ A+ N A + A TP N LG +F L D+ + G +A Sbjct: 348 TGALKAKVDGNKAKLAGKMTAETPSGMMNYSNSLGVVRDFMLANPDISLVNEGANAL--- 404 Query: 397 QTTFPNNTYGISQVL----------WGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGS 446 +NT I +L WG +G G + AA K VI GD + Sbjct: 405 -----DNTRMIVDMLKPRKRLDSGTWGVMGIGMGYCVAAAAVT-----GKPVIAVEGDSA 454 Query: 447 LQLTVQEISTMIRWGLKPYLFVLNNDG 473 + E+ T+ R+ L + ++NN G Sbjct: 455 FGFSGMELETICRYNLPVTVIIMNNGG 481 >4Q9D-A nrPDB Length = 545 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 121/528 (22%), Positives = 211/528 (39%), Gaps = 61/528 (11%) Query: 5 TLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARI 64 T+ ++ L+++ + TVFG PG S L E + + E +A ADG+A+ Sbjct: 6 TVHDVTYDLLRKLGLTTVFGNPGSTEESFLRDF--PEDFTYVLSLQEASALAMADGFAQA 63 Query: 65 KGMSCII---TTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQL-LLHHTLGNG 120 G ++ T G G +A+ + +Y + ++ G Q +++ ++ L N Sbjct: 64 TGKPALVNLHTAAGTG--NAMGSLVAAYRANTPLIITAG-----QQTREMSVVDPYLNNP 116 Query: 121 DFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQR-PVYLGLPANLVDLNVPAK 179 D T + S A D+ PA + PV+L +P + D Sbjct: 117 DATTMPKPWVKWSYEPARAEDV---PAAFMQAYAVAMQPPMGPVFLSIPLDDWDKPALGP 173 Query: 180 LLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQ 239 + + P DAE + + I A AK+P+++ R + + Sbjct: 174 AAVRSVSTRVAP-DAERLAQFAERINA----AKHPMLVLGPEVDRAGAWDAGIEFAEKLG 228 Query: 240 FPAFVTPM-GKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFS 298 P + + + S E HP Y G T++ V++AV + DL++ VGA + + Sbjct: 229 APVHASALPDRMSFPEDHPLYAGPLPMTIAG--VEQAVSAYDLVVVVGAEVFRY------ 280 Query: 299 YSYKTKNIVEFHSDHMKI-----RNATFP---------GVQMKFVLQKLLTTIADAAKGY 344 Y Y + +D ++I R+A P G+ + L +L+ T D Sbjct: 281 YPYVPGEYLPEGTDLLQITADPHRSAVAPVGDSLVGDVGIALSR-LTELIDTPDDRVPP- 338 Query: 345 KPVAVPARTPANAAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSA---FGINQTTFP 401 KP+ V R ++ +P++ P+ ++ L N + V+ E+ ++ F TT P Sbjct: 339 KPL-VRQR---HSDIPSTAPMTSNAVYEVLSNVKPDDAAVVMESTSTMLDLFTWLPTTHP 394 Query: 402 NNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWG 461 + + G IG+ A +G A + V+ IGDGS Q ++Q I T + Sbjct: 395 ASFFATGS---GGIGWGVPAAVGIALGDRARGVDRTVVATIGDGSFQYSIQAIWTAAQHK 451 Query: 462 LKPYLFVLNNDGYTIEK----LIHGPKAQYNEIQGWDHLSLLPTFGAK 505 L VL N Y I K L P ++ G D S+ FG + Sbjct: 452 LPIVFVVLRNGEYAILKSFADLEKTPNVPGLQLPGLDISSIAAGFGCR 499 >5AHK-A nrPDB Length = 588 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 101/489 (20%), Positives = 176/489 (35%), Gaps = 65/489 (13%) Query: 18 NVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARI---KGMSCIITTF 74 NV F L G L+D I + + +E AA+AA +R+ K + + T Sbjct: 35 NVLYGFELIGGMITHLVDSINLLGKTKLVSMHHEQGAAFAASAVSRVTHHKTLGLALATS 94 Query: 75 GVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTVFHRMSANISE 134 G G + + GIA + + + + G Q+ H G D + + Sbjct: 95 GPGATNLITGIADCWLDSHPCIFLTG---------QVNTHELKGKRD---IRQQGFQELD 142 Query: 135 TTAMITDIATAPAEIDR------CIRTTYVTQR-----PVYLGLPANLVDLNVPAKLLQT 183 + A++T I +I C+R + PV L +P ++ ++ LL Sbjct: 143 SVALVTSITKYAYQIKSADELVPCLRKAIQIAKEGRPGPVLLDIPMDIQRADIDEALLNN 202 Query: 184 PIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFPAF 243 P+ K +D I+ +++AK P++L + + I+L P Sbjct: 203 PMTPEPKVQRPSIAMSDLDFIINKLQNAKKPLLLIGGGAVNSSGFQKWLEQIELRGIPYV 262 Query: 244 VTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYSY-K 302 + G I G +G AV++ DL+L +G+ + TG+ + + Sbjct: 263 ASLKGAEKIKASDLYLG--MLGAYGTRAANHAVQNCDLLLVLGSRMDVRQTGAQPEDFAR 320 Query: 303 TKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANAAVPAS 362 I++ ++ N + L + + + P + P N Sbjct: 321 NAEIIQIDLQEGQLNNRVIADFSYQIELSEYFSRFS-----------PLQIPVNNDWSVW 369 Query: 363 TPLKQE------------WMWNQLGNFLQEGDVV-------IAETGTSAFGINQTTFPNN 403 T L +E W + G F Q + I + G + T N Sbjct: 370 TALLKEKFRVTFIDEYTTWNLSPFGLFTQLNKLTERVALDYILDVGNNQMWAAHTLRLNA 429 Query: 404 TYGISQV-LWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGL 462 + GS+GF A +GA +A KK +I+ GDG QL +QE+ + R L Sbjct: 430 QQAMHHSGGLGSMGFAIPAAIGACYAG-----KKPIIVITGDGGAQLNIQELDIIARDKL 484 Query: 463 KPYLFVLNN 471 V+NN Sbjct: 485 PILTIVMNN 493 >4QQ8-A nrPDB Length = 583 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 132/581 (22%), Positives = 225/581 (38%), Gaps = 57/581 (9%) Query: 1 MSEITLGKYLFERLKQVNVNTVFGLPG----DFNLSLLDKIYEVEGMRWAGNANELNAAY 56 M+ IT G+ + L + V +FGL G + LD + R A Y Sbjct: 1 MAMITGGELVVRTLIKAGVEHLFGLHGIHIDTIFQACLDHDVPIIDTRHEAAAGHAAEGY 60 Query: 57 AADGYARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHT 116 A G + + T G G +A+ IA + + VL + G ++ +T Sbjct: 61 ARAG----AKLGVALVTAGGGFTNAVTPIANARTDRTPVLFLTGSGALRDDET-----NT 111 Query: 117 LGNGDFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQR-PVYLGLPANLVDLN 175 L G V M+A I++ + P + + IR R PV L LP +++ Sbjct: 112 LQAGIDQV--AMAAPITKWAHRVMATEHIPRLVMQAIRAALSAPRGPVLLDLPWDILMNQ 169 Query: 176 VPAKLLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLI 235 + + P D+ L + A + +D LAL++ A+ PVI+ + SR K + Sbjct: 170 IDEDSVIIP-DLVLSAHGAHPDPADLDQALALLRKAERPVIVLGSEASRTARKTALSAFV 228 Query: 236 DLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTG 295 T P F G + G V L +A + DL+L +GA NTG Sbjct: 229 AATGVPVFADYEGLSMLSGLPDAMRGGLVQNLYS--FAKADAAPDLVLMLGARFG-LNTG 285 Query: 296 SFSYSY--KTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPART 353 S + +++ D ++ G+ + V T A A + A P R Sbjct: 286 HGSGQLIPHSAQVIQVDPDACEL--GRLQGIALGIVADVGGTIEALAQATAQDAAWPDRG 343 Query: 354 PANAAVPASTPLKQE-----------------WMWNQ-LGNFLQEGDVVIAETGTSAFGI 395 A V T L QE + +Q + + G V+A+ G + + Sbjct: 344 DWCAKV---TDLAQERYASIAAKSSSEHALHPFHASQVIAKHVDAGVTVVADGGLTYLWL 400 Query: 396 NQTTFPNNTYG-ISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEI 454 ++ G + S+G G LGA A +++ +R IL GDGS+ ++ E Sbjct: 401 SEVMSRVKPGGFLCHGYLNSMGVGFGTALGAQVA--DLEAGRRTILVTGDGSVGYSIGEF 458 Query: 455 STMIRWGLKPYLFVLNND--GYTI--EKLIHGP-KAQYNEIQGWDHLSLLPTFGAKDYET 509 T++R L + ++NN G+T+ ++L GP + ++ + + FGA Y Sbjct: 459 DTLVRKQLPLIVIIMNNQSWGWTLHFQQLAVGPNRVTGTRLENGSYHGVAAAFGADGYHV 518 Query: 510 HRVATTGEWDKLTQDKSFNDNSKIRMIEIMLPVFDAPQNLV 550 V + L Q + N + I + + P+ P+ L+ Sbjct: 519 DSVESFSA--ALAQALAHNRPACINVAVALDPI--PPEELI 555 >5D6R-B nrPDB Length = 579 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 111/534 (20%), Positives = 218/534 (40%), Gaps = 73/534 (13%) Query: 10 LFERLKQVNVNTVFGLPGDFNLSLLDKIYEV---EGMRWAGNANELNAAYAADGYARIKG 66 + +L+ V VFG+PG + +DK+++ +R +E NAA+ A RI G Sbjct: 37 VVSQLEAQGVRQVFGIPG----AKIDKVFDSLLDSSIRIIPVRHEANAAFMAAAVGRITG 92 Query: 67 MSCI-ITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTVF 125 + + + T G G + + G+A + +E V+ + G + +AKQ+ H ++ Sbjct: 93 KAGVALVTSGPGCSNLITGMATANSEGDPVVALGGAVKRADKAKQV--HQSM-------- 142 Query: 126 HRMSANISETTAMITDI------ATAPAEIDRCIRTTYVTQ---RP--VYLGLPANLVDL 174 +T AM + + TAP + + + RP ++ LP ++VD Sbjct: 143 --------DTVAMFSPVTKYAIEVTAPDALAEVVSNAFRAAEQGRPGSAFVSLPQDVVDG 194 Query: 175 NVPAKLLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKL 234 V K+L S P + + ID + L+ AKNP+ L S+ + ++L Sbjct: 195 PVSGKVLPA----SGAPQMGAAPDDAIDQVAKLIAQAKNPIFLLGLMASQPENSKALRRL 250 Query: 235 IDLTQFPAFVTPMGKGSIDEQH-PRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDF- 292 ++ + P T G++++ + R+ G VG + ++ ADL++ +G ++ Sbjct: 251 LETSHIPVTSTYQAAGAVNQDNFSRFAG-RVGLFNNQAGDRLLQLADLVICIGYSPVEYE 309 Query: 293 ----NTGSFSY-------SYKTKNI---VEFHSDHMKIRNATFPGVQMKFVLQKLLTTIA 338 N+G+ + +Y+ +N VE D N + + VL I Sbjct: 310 PAMWNSGNATLVHIDVLPAYEERNYTPDVELVGDIAGTLNKLAQNIDHRLVLSPQAAEIL 369 Query: 339 DAAKGYKPVAVPARTPANAAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQT 398 + + + R A A PL+ + + + + + + G+ I + Sbjct: 370 RDRQHQRELL--DRRGAQLNQFALHPLR---IVRAMQDIVNSDVTLTVDMGSFHIWIARY 424 Query: 399 TFPNNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMI 458 + ++ QV+ + T G L A A ++P+++V+ GDG + E+ T + Sbjct: 425 LY---SFRARQVMISNGQQTMGVALPWAIGAWLVNPERKVVSVSGDGGFLQSSMELETAV 481 Query: 459 RWGLKPYLFVLNNDGYTIEKLIHGPKAQYNEIQG-----WDHLSLLPTFGAKDY 507 R + ++GY + + K Y + G D + +FGAK + Sbjct: 482 RLKANVLHLIWVDNGYNMVAIQEEKK--YQRLSGVEFGPMDFKAYAESFGAKGF 533 >2EZ4-A nrPDB Length = 603 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 112/500 (22%), Positives = 203/500 (40%), Gaps = 58/500 (11%) Query: 2 SEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIY-EVEGMRWAGNANELNAAYAADG 60 + I G + + L+ V+ ++G+PG S++D + E + + + +E A AA Sbjct: 9 TNILAGAAVIKVLEAWGVDHLYGIPGGSINSIMDALSAERDRIHYIQVRHEEVGAMAAAA 68 Query: 61 YARIKG-MSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGN 119 A++ G + + G G +NG+ + +HV VL ++G + Sbjct: 69 DAKLTGKIGVCFGSAGPGGTHLMNGLYDAREDHVPVLALIGQFGTTGM------------ 116 Query: 120 GDFTVFHRMS-----ANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDL 174 + F M+ A++++ + AT P ID IR Y Q + +P +L Sbjct: 117 -NMDTFQEMNENPIYADVADYNVTAVNAATLPHVIDEAIRRAYAHQGVAVVQIPVDLPWQ 175 Query: 175 NVPAK-------LLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDV 227 +PA+ QTP+ L D ++ + T+LA A+ P+I + Sbjct: 176 QIPAEDWYASANSYQTPL---LPEPDVQAVTRLTQTLLA----AERPLIYYGIGARK--A 226 Query: 228 KAETKKLIDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGA 287 E ++L + P T KG + +++P Y G KP EA+ AD++L VG Sbjct: 227 GKELEQLSKTLKIPLMSTYPAKGIVADRYPAYLGSANRVAQKP-ANEALAQADVVLFVG- 284 Query: 288 LLSDFNTGSFSYSYK-TKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKP 346 +++ S ++K T+ ++ D K+ + + QK L I + Sbjct: 285 --NNYPFAEVSKAFKNTRYFLQIDIDPAKLGKRHKTDIAVLADAQKTLAAILAQVSERES 342 Query: 347 VAVPARTPANA----AVPASTPLKQE-----WMWNQLGNFLQEGDVVIA-ETGTSAFGIN 396 AN A AS KQE + + N + E D + + + G N Sbjct: 343 TPWWQANLANVKNWRAYLASLEDKQEGPLQAYQVLRAVNKIAEPDAIYSIDVGDINLNAN 402 Query: 397 Q--TTFPNNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEI 454 + P+N + S + T G + A AA+ P+++V GDG +T+Q++ Sbjct: 403 RHLKLTPSNRHITSNLF-----ATMGVGIPGAIAAKLNYPERQVFNLAGDGGASMTMQDL 457 Query: 455 STMIRWGLKPYLFVLNNDGY 474 +T +++ L V N Y Sbjct: 458 ATQVQYHLPVINVVFTNCQY 477 >2PGN-A nrPDB Length = 589 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 111/507 (21%), Positives = 171/507 (33%), Gaps = 77/507 (15%) Query: 10 LFERLKQVNVNTVFGLPGDFNLSLLDKIYEVE-GMRWAGNANELNAAYAADGYARIKGMS 68 + E L++ V G G + + D + G R A EL A+ +GY +K S Sbjct: 10 IVEALEEYGTEQVVGFIGHTSHFVADAFSKSHLGKRVINPATELGGAWMVNGYNYVKDRS 69 Query: 69 CIITTFGVGELSALNGIAGSYAEHVGVLHVVG-----VPSISAQAKQLLLHHTLGNGDFT 123 VG H VG A+ ++ H N D Sbjct: 70 AA----------------------VGAWHCVGNLLLHAAMQEARTGRIPAVHIGLNSDGR 107 Query: 124 VFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRP--VYLGLPANLVDLNVPAKLL 181 + R A T IA + ++R + V G PA +++P L Sbjct: 108 LAGRSEAAQQVPWQSFTPIARSTQRVERLDKVGEAIHEAFRVAEGHPAGPAYVDIPFDLT 167 Query: 182 QTPID-MSLKPNDAESEKEVIDTILALVKDA-------KNPVILADACCSRHDVKAETKK 233 ID +L P A K V+ V++A KNPVILA +R K Sbjct: 168 ADQIDDKALVPRGATRAKSVLHAPNEDVREAAAQLVAAKNPVILAGGGVARSGGSEALLK 227 Query: 234 LIDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFN 293 L ++ P T G G E H G G + + +AD +L +G+ LSD+ Sbjct: 228 LAEMVGVPVVTTSTGAGVFPETHALAMG-SAGFCGWKSANDMMAAADFVLVLGSRLSDWG 286 Query: 294 TGSFSYSYKTKNIVEFHSDHMKIRNATFPGVQM----KFVLQKLLTTIADAAKGYKPVAV 349 Y K V +D + FP + + K +++L+ + G+K V Sbjct: 287 IAQ-GYITKMPKFVHVDTDPAVLGTFYFPLLSVVADAKTFMEQLIEVLP-GTSGFKAVRY 344 Query: 350 PARTPANAAVPASTPLKQEW----------------MWNQLGNFL---QEGDVVIAETGT 390 R A T + W M+ + + D+++ + G Sbjct: 345 QERENFRQA----TEFRAAWDGWVREQESGDGMPASMFRAMAEVRKVQRPEDIIVTDIGN 400 Query: 391 SA---FGINQTTFPNNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSL 447 FG P ++ + G +G LGA A +P RV L GDG+L Sbjct: 401 HTLPMFGGAILQRPRRL--VTSMAEGILGCGFPMALGAQLA----EPNSRVFLGTGDGAL 454 Query: 448 QLTVQEISTMIRWGLKPYLFVLNNDGY 474 E + L V N+ Y Sbjct: 455 YYHFNEFRVAVEHKLPVITMVFTNESY 481 >2Q28-A nrPDB Length = 564 Score = 48.5 bits (114), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 76/291 (26%), Positives = 123/291 (42%), Gaps = 32/291 (10%) Query: 10 LFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARIKGMSC 69 + E LKQ N++T++G+ G ++ + + + EG+R+ G +E +A YAA + Sbjct: 14 IVEALKQNNIDTIYGVVG-IPVTDMARHAQAEGIRYIGFRHEQSAGYAAAASGFLTQKPG 72 Query: 70 IITTFGV-GELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTVFHRM 128 I T G L+ L +A + V G P I L GD+ +M Sbjct: 73 ICLTVSAPGFLNGLTALANAT--------VNGFPMIMISGSSDRAIVDLQQGDYEELDQM 124 Query: 129 SANISETTAMI-----TDIATAPAEIDRCIRTTYVTQRP--VYLGLPANLVDLNVPAKLL 181 +A A D+ A A R IR + V+ RP VYL LPAN++ + Sbjct: 125 NAAKPYAKAAFRVNQPQDLGIALA---RAIRVS-VSGRPGGVYLDLPANVLAATMEKDEA 180 Query: 182 QTPIDMSLKPNDA--ESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQ 239 T I P+ A K V I L K A+ P+I+ + + ++ I+ Q Sbjct: 181 LTTIVKVENPSPALLPCPKSVTSAISLLAK-AERPLIILGKGAAYSQADEQLREFIESAQ 239 Query: 240 FPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLS 290 P M KG +++ HP + A+ +AD+++ VGA L+ Sbjct: 240 IPFLPMSMAKGILEDTHP--------LSAAAARSFALANADVVMLVGARLN 282 Score = 32.3 bits (72), Expect = 0.63, Method: Compositional matrix adjust. Identities = 17/62 (27%), Positives = 28/62 (45%), Gaps = 5/62 (8%) Query: 412 WGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNN 471 WG +G G +GA+ + V+ GD + + EI T+ R+ L + + NN Sbjct: 420 WGVMGIGMGYAIGASVTS-----GSPVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNN 474 Query: 472 DG 473 G Sbjct: 475 GG 476 >3EYA-A nrPDB Length = 549 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 98/504 (19%), Positives = 192/504 (38%), Gaps = 84/504 (16%) Query: 5 TLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARI 64 T+ Y+ + L+ V ++G+ GD L D + + + W +E AA+AA A++ Sbjct: 4 TVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQL 63 Query: 65 KG-MSCIITTFGVGELSALNGIAGSYAEHVGVLHVVG-VPSISAQAKQLLLHHTLGNGDF 122 G ++ + G G L +NG+ + HV VL + +PS +G+G F Sbjct: 64 SGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPS-----------SEIGSGYF 112 Query: 123 TVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLLQ 182 H + + ++ ++P +I P L + LN ++ Sbjct: 113 QETH--PQELFRECSHYCELVSSPEQI------------PQVLAIAMRKAVLNRGVSVVV 158 Query: 183 TPIDMSLKPNDAES--------------EKEVIDTILALVKDAKNPVILADACCSRHDVK 228 P D++LKP + E+E + + L++ + N ++ + C+ Sbjct: 159 LPGDVALKPAPEGATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSGCA----- 213 Query: 229 AETKKLIDLT---QFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSV 285 K+L++ + P GK ++ +P G+ G + + +AD ++ + Sbjct: 214 GAHKELVEFAGKIKAPIVHALRGKEHVEYDNPYDVGM-TGLIGFSSGFHTMMNADTLVLL 272 Query: 286 G------------ALLSDFNTGSFSYSYKTKNIVEFHSDHMKIRNATFPGVQMKF---VL 330 G A + + S +K + D A P V+ K L Sbjct: 273 GTQFPYRAFYPTDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFL 332 Query: 331 QKLLTTIADAAKGYKPVAVPARTPANAAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGT 390 K L DA KG + A P+ + +++ Q+ +F + + + GT Sbjct: 333 DKALEDYRDARKGLD----------DLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGT 382 Query: 391 SAFGINQTTFPNNTYGISQVLWGSIGFTTGATLGA---AFAAEEIDPKKRVILFIGDGSL 447 + N + L GS F G+ A A A+ +P+++V+ GDG Sbjct: 383 PTVWAARYLKMNG----KRRLLGS--FNHGSMANAMPQALGAQATEPERQVVAMCGDGGF 436 Query: 448 QLTVQEISTMIRWGLKPYLFVLNN 471 + + + ++++ L + V NN Sbjct: 437 SMLMGDFLSVVQMKLPVKIVVFNN 460 >4RJK-A nrPDB Length = 571 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 99/484 (20%), Positives = 188/484 (38%), Gaps = 55/484 (11%) Query: 14 LKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARIKGM-SCIIT 72 L + V VFG+PG ++ D + + +G +E NAA+ A R+ G ++ Sbjct: 25 LVEQGVTHVFGIPGAKIDAVFDALQD-KGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLV 83 Query: 73 TFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTVFHRMSANI 132 T G G + G+ + E V+ + G + + K+ H +L N +F I Sbjct: 84 TSGPGASNLATGLLTANTEGDPVVALAGNVIRADRLKRT--HQSLDNA--ALFQ----PI 135 Query: 133 SETTAMITDIATAPAEIDRCIRTTYVTQR-PVYLGLPANLVDLNVPAKLLQTPIDMSLKP 191 ++ + + D+ P + R Q ++ P ++V+ K ++ L P Sbjct: 136 TKYSVEVQDVKNIPEAVTNAFRIASAGQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGP 195 Query: 192 NDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFPAFVTPMGKGS 251 ++ I I + AK PV+L R + +KL+ Q P T G+ Sbjct: 196 AADDAISAAIAKI----QTAKLPVVLVGMKGGRPEAIKAVRKLLKKVQLPFVETYQAAGT 251 Query: 252 IDEQ-HPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYSYKTKNIVEFH 310 + +Y G +G +E AD++L++G +++ F + I+ Sbjct: 252 LSRDLEDQYFG-RIGLFRNQPGDLLLEQADVVLTIGYDPIEYDP-KFWNINGDRTIIHLD 309 Query: 311 SDHMKIRNATFP------------------GVQMKFV--LQKLLTTIADAAKGYKPVAVP 350 I +A P V+++F QK+L+ + ++ VP Sbjct: 310 EIIADIDHAYQPDLELIGDIPSTINHIEHDAVKVEFAEREQKILSDLKQYM--HEGEQVP 367 Query: 351 ARTPANAAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQ--TTFPNNTYGIS 408 A ++ A P + +L N + + V + G+ A +++ ++ T IS Sbjct: 368 ADWKSDRAHPLE-------IVKELRNAVDDHVTVTCDIGSHAIWMSRYFRSYEPLTLMIS 420 Query: 409 QVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFV 468 + T G L A A + P ++V+ GDG + E+ T +R P + + Sbjct: 421 NGMQ-----TLGVALPWAIGASLVKPGEKVVSVSGDGGFLFSAMELETAVRLK-APIVHI 474 Query: 469 LNND 472 + ND Sbjct: 475 VWND 478 >1UPC-A nrPDB Length = 573 Score = 38.1 bits (87), Expect = 0.010, Method: Compositional matrix adjust. Identities = 111/478 (23%), Positives = 178/478 (37%), Gaps = 75/478 (15%) Query: 39 EVEGMRWAGNANELNAAYAADGYARIKG--MSCIITTFGVGELSALNGIAGSYAEHVGVL 96 EVEG+ + +E A AAD ARI G +C T G G + GIA S + V+ Sbjct: 45 EVEGIDFVLTRHEFTAGVAADVLARITGRPQACW-ATLGPGMTNLSTGIATSVLDRSPVI 103 Query: 97 HVVGVPSISAQAKQLLLHHTLGNGDFTVFHRMSANISETTAMITDIATAPAEIDRCIRTT 156 +++AQ++ +F + ++ A++ ++ E+ R T Sbjct: 104 ------ALAAQSES-----------HDIFPNDTHQCLDSVAIVAPMSKYAVELQRPHEIT 146 Query: 157 YVTQR-----------PVYLGLPANL------VDLNVPAKLLQTPIDMSLKPND--AESE 197 + P ++ LP +L +D VP TP KP A+ Sbjct: 147 DLVDSAVNAAMTEPVGPSFISLPVDLLGSSEGIDTTVPNPPANTP----AKPVGVVADGW 202 Query: 198 KEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFPAFVTPMGKGSIDEQHP 257 ++ D AL+ +AK+PV++ A R + L + P T + KG + H Sbjct: 203 QKAADQAAALLAEAKHPVLVVGAAAIRSGAVPAIRALAERLNIPVITTYIAKGVLPVGHE 262 Query: 258 -RYGGV--YV-GTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYSYKTKNIVEFHSDH 313 YG V Y+ G L+ P ++ DL+L+VG ++ S K V Sbjct: 263 LNYGAVTGYMDGILNFPALQTMFAPVDLVLTVGYDYAEDLRPSMWQKGIEKKTVRISPTV 322 Query: 314 MKIRNATFPGVQ-----MKFVLQKLLTTIADAAKGYKPV-AVPARTPANAAVPASTP--L 365 I P V + FV T + AK + + AR A P + + Sbjct: 323 NPIPRVYRPDVDVVTDVLAFVEHFETATASFGAKQRHDIEPLRARIAEFLADPETYEDGM 382 Query: 366 KQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGS----IGFTTGA 421 + + + + ++E AE G + F YG VL+ GF T A Sbjct: 383 RVHQVIDSMNTVMEEA----AEPGEGTIVSDIGFF--RHYG---VLFARADQPFGFLTSA 433 Query: 422 -------TLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNND 472 + AA A+ P + L GDG ++ T+ R L V+NND Sbjct: 434 GCSSFGYGIPAAIGAQMARPDQPTFLIAGDGGFHSNSSDLETIARLNLPIVTVVVNND 491 >1V5E-A nrPDB Length = 590 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 93/500 (18%), Positives = 187/500 (37%), Gaps = 50/500 (10%) Query: 2 SEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVE-GMRWAGNANELNAAYAADG 60 ++I +G + + L+ +T++G+P SL+D + E E +++ +E A AA Sbjct: 2 NKINIGLAVMKILESWGADTIYGIPSGTLSSLMDAMGEEENNVKFLQVKHEEVGAMAAVM 61 Query: 61 YARIKG-MSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGV---PSISAQAKQLLLHHT 116 ++ G + + + G G +NG+ + +++ V+ ++G ++ A Q L + Sbjct: 62 QSKFGGNLGVTVGSGGPGASHLINGLYDAAMDNIPVVAILGSRPQRELNMDAFQELNQNP 121 Query: 117 LGNGDFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNV 176 + + V++R A + P +D R + L +P + + + Sbjct: 122 MYD-HIAVYNRRVAYAEQL----------PKLVDEAARMAIAKRGVAVLEVPGDFAKVEI 170 Query: 177 PAKLLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLID 236 + + K + ID + L+ ++K PVI A H ++L Sbjct: 171 DNDQWYSSANSLRKYAPIAPAAQDIDAAVELLNNSKRPVIYAGIGTMGH--GPAVQELAR 228 Query: 237 LTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGS 296 + P T + + G KP E + AD +L G S+F Sbjct: 229 KIKAPVITTGKNFETFEWDFEALTGSTYRVGWKP-ANETILEADTVLFAG---SNFPFSE 284 Query: 297 FSYSYKT-KNIVEFHSDHMKIRNATFPGVQM----KFVLQKLLTTIADAAKGYKPVAVPA 351 +++ N ++ D + V + + ++L + DA + Sbjct: 285 VEGTFRNVDNFIQIDIDPAMLGKRHHADVAILGDAALAIDEILNKV-DAVEESAWWTANL 343 Query: 352 RTPAN-------AAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTF---- 400 + AN L+ ++N + N E + + G S QT+ Sbjct: 344 KNIANWREYINMLETKEEGDLQFYQVYNAINNHADEDAIYSIDVGNST----QTSIRHLH 399 Query: 401 --PNNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMI 458 P N + S L+ ++G LG A+ P ++V IGDG+ +T ++ T + Sbjct: 400 MTPKNMWRTSP-LFATMGIAIPGGLG----AKNTYPDRQVWNIIGDGAFSMTYPDVVTNV 454 Query: 459 RWGLKPYLFVLNNDGYTIEK 478 R+ + V +N Y K Sbjct: 455 RYNMPVINVVFSNTEYAFIK 474 >6J5T-G nrPDB Length = 852 Score = 30.0 bits (66), Expect = 3.1, Method: Compositional matrix adjust. Identities = 15/34 (44%), Positives = 21/34 (61%), Gaps = 2/34 (5%) Query: 515 TGEWDKLTQD--KSFNDNSKIRMIEIMLPVFDAP 546 TGE +KL D K F D +R+++I +FDAP Sbjct: 541 TGEVNKLNSDLAKKFTDCKYLRVLDISKSIFDAP 574 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1QPB-A nrPDB 731 0.0 6EFG-A nrPDB 686 0.0 5NPU-A nrPDB 607 e-174 2VBI-A nrPDB 566 e-161 5EUJ-A nrPDB 552 e-157 2VBF-A nrPDB 547 e-156 4ZP1-A nrPDB 528 e-150 4COK-A nrPDB 526 e-150 1OVM-A nrPDB 523 e-149 2Q5O-A nrPDB 408 e-114 1T9B-A nrPDB 376 e-104 6DEO-A nrPDB 371 e-103 4QQ8-A nrPDB 364 e-101 2PAN-A nrPDB 360 1e-99 5WJ1-A nrPDB 359 1e-99 5AHK-A nrPDB 352 2e-97 6A50-A nrPDB 352 3e-97 4Q9D-A nrPDB 337 9e-93 2EZ4-A nrPDB 330 1e-90 2JI6-A nrPDB 322 3e-88 5D6R-B nrPDB 321 5e-88 2PGN-A nrPDB 319 2e-87 3EYA-A nrPDB 309 2e-84 2Q28-A nrPDB 273 2e-73 Sequences not found previously or not previously below threshold: 4RJK-A nrPDB 267 8e-72 4K9Q-A nrPDB 267 1e-71 1V5E-A nrPDB 265 2e-71 1UPC-A nrPDB 193 1e-49 3LQ1-A nrPDB 102 6e-22 2X7J-A nrPDB 98 8e-21 2JLA-A nrPDB 94 2e-19 5ESS-A nrPDB 68 9e-12 3CF4-G nrPDB 45 9e-05 5B48-A nrPDB 41 0.001 3I9V-3 nrPDB 40 0.003 6N2O-B nrPDB 39 0.005 5B47-B nrPDB 39 0.006 5B46-A nrPDB 38 0.011 2O1S-A nrPDB 37 0.022 1YTL-A nrPDB 37 0.025 4KXX-A nrPDB 34 0.14 4DI9-A nrPDB 34 0.24 3T6J-A nrPDB 33 0.43 5JLR-A nrPDB 33 0.52 5JTL-E nrPDB 33 0.54 3DVA-A nrPDB 32 0.60 6N2O-A nrPDB 32 0.68 3ILN-A nrPDB 32 0.83 3BC1-A nrPDB 31 1.0 1M93-B nrPDB 31 1.3 1C8O-A nrPDB 31 1.3 2O1X-A nrPDB 31 1.4 1X7Z-A nrPDB 31 1.4 1RT8-A nrPDB 31 1.7 6GCS-A nrPDB 30 2.3 6C43-A nrPDB 30 2.7 3DTI-A nrPDB 30 2.8 1QS0-A nrPDB 29 3.8 5Q0C-A nrPDB 29 5.2 3CME-F nrPDB 28 9.2 >1QPB-A nrPDB Length = 563 Score = 731 bits (1887), Expect = 0.0, Method: Composition-based stats. Identities = 559/563 (99%), Positives = 561/563 (99%) Query: 1 MSEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADG 60 MSEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADG Sbjct: 1 MSEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADG 60 Query: 61 YARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNG 120 YARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNG Sbjct: 61 YARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNG 120 Query: 121 DFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKL 180 DFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKL Sbjct: 121 DFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKL 180 Query: 181 LQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQF 240 LQTPIDMSLKPNDAESEKEVIDTIL L+KDAKNPVILADACCSRHDVKAETKKLIDLTQF Sbjct: 181 LQTPIDMSLKPNDAESEKEVIDTILVLIKDAKNPVILADACCSRHDVKAETKKLIDLTQF 240 Query: 241 PAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYS 300 PAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYS Sbjct: 241 PAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYS 300 Query: 301 YKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANAAVP 360 YKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLT IADAAKGYKPVAVPARTPANAAVP Sbjct: 301 YKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTAIADAAKGYKPVAVPARTPANAAVP 360 Query: 361 ASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTG 420 ASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTG Sbjct: 361 ASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTG 420 Query: 421 ATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLI 480 ATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLI Sbjct: 421 ATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLI 480 Query: 481 HGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSFNDNSKIRMIEIML 540 HGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSFNDNSKIRMIE+ML Sbjct: 481 HGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSFNDNSKIRMIEVML 540 Query: 541 PVFDAPQNLVEQAKLTAATNAKQ 563 PVFDAPQNLVEQAKLTAATNAKQ Sbjct: 541 PVFDAPQNLVEQAKLTAATNAKQ 563 >6EFG-A nrPDB Length = 563 Score = 686 bits (1771), Expect = 0.0, Method: Composition-based stats. Identities = 485/562 (86%), Positives = 519/562 (92%) Query: 1 MSEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADG 60 MSEITLG+YLFERLKQV V T+FGLPGDFNLSLLD IYEV GMRWAGNANELNAAYAADG Sbjct: 1 MSEITLGRYLFERLKQVEVQTIFGLPGDFNLSLLDNIYEVPGMRWAGNANELNAAYAADG 60 Query: 61 YARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNG 120 YAR+KGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPS+S+QAKQLLLHHTLGNG Sbjct: 61 YARLKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSVSSQAKQLLLHHTLGNG 120 Query: 121 DFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKL 180 DFTVFHRMS+NISETTAMITDI TAPAEIDRCIRTTYV+QRPVYLGLPANLVDL VPA L Sbjct: 121 DFTVFHRMSSNISETTAMITDINTAPAEIDRCIRTTYVSQRPVYLGLPANLVDLTVPASL 180 Query: 181 LQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQF 240 L TPID+SLKPND E+E+EVI+ +L L+K+AKNPVILADACCSRHD KAETKKLIDLTQF Sbjct: 181 LDTPIDLSLKPNDPEAEEEVIENVLQLIKEAKNPVILADACCSRHDAKAETKKLIDLTQF 240 Query: 241 PAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYS 300 PAFVTPMGKGSIDE+HPR+GGVYVGTLS P VKEAVESADL+LSVGALLSDFNTGSFSYS Sbjct: 241 PAFVTPMGKGSIDEKHPRFGGVYVGTLSSPAVKEAVESADLVLSVGALLSDFNTGSFSYS 300 Query: 301 YKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANAAVP 360 YKTKNIVEFHSD+ KIR+ATFPGVQMKF LQKLLT +ADAAKGYKPV VP+ N AV Sbjct: 301 YKTKNIVEFHSDYTKIRSATFPGVQMKFALQKLLTKVADAAKGYKPVPVPSEPEHNEAVA 360 Query: 361 ASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTG 420 STPLKQEW+W Q+G FL+EGDVVI ETGTSAFGINQT FPNNTYGISQVLWGSIGFTTG Sbjct: 361 DSTPLKQEWVWTQVGEFLREGDVVITETGTSAFGINQTHFPNNTYGISQVLWGSIGFTTG 420 Query: 421 ATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLI 480 ATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIE+LI Sbjct: 421 ATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIERLI 480 Query: 481 HGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSFNDNSKIRMIEIML 540 HG AQYN IQ W HL LLPTFGAKDYE RV+TTGEW+KLT D+ F DN++IR+IE+ML Sbjct: 481 HGETAQYNCIQNWQHLELLPTFGAKDYEAVRVSTTGEWNKLTTDEKFQDNTRIRLIEVML 540 Query: 541 PVFDAPQNLVEQAKLTAATNAK 562 P DAP NLV+QA+LTAATNAK Sbjct: 541 PTMDAPSNLVKQAQLTAATNAK 562 >5NPU-A nrPDB Length = 563 Score = 607 bits (1564), Expect = e-174, Method: Composition-based stats. Identities = 173/563 (30%), Positives = 268/563 (47%), Gaps = 11/563 (1%) Query: 4 ITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYAR 63 T+G YL RL Q+ + F + GD+NL LLD++ + + + NELN ++A+GYAR Sbjct: 3 YTVGHYLATRLAQIGLKHHFAVAGDYNLVLLDQLLKNKDLEQVYCCNELNCGFSAEGYAR 62 Query: 64 IKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFT 123 G+ + TF VG LSA N I G+YAE++ V+ + G P+ + +LHHT+G D+ Sbjct: 63 ANGVGAAVVTFSVGALSAFNAIGGAYAENLPVILISGAPNTNDHGSGHILHHTIGTTDYG 122 Query: 124 VFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLLQT 183 M+ I+ IT APA ID IRT ++P Y+ + N+ + Sbjct: 123 YQLEMAKQITCAAVSITHAEDAPALIDHAIRTALREKKPAYIEIACNVAAQPCARPGPVS 182 Query: 184 PIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFPAF 243 + +D E+ K ++ L ++ + PV+L + +L D Sbjct: 183 ALLNEPT-SDEETLKAAVEAALDFIEKREKPVLLVGGKLRAAGAEEAVVELADALGCAVA 241 Query: 244 VTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYSYKT 303 K E HP Y G Y G +S P V+E V+ AD I+ +G + +D++T ++ K Sbjct: 242 TMAAAKSFFPEDHPGYVGTYWGEVSSPGVEEIVDWADGIICLGPVFNDYSTVGWTAWPKG 301 Query: 304 KNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANAAVPA-- 361 +N+V H+ + F G+ +K L L + PA VPA Sbjct: 302 ENVVLVDPHHITVGGEEFTGIHLKDFLTALTERVPKKDATLDQFKARVGKPAAEKVPAAD 361 Query: 362 -STPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTG 420 + PL + + Q+ L +IAETG S F + P+ ++ WG IG++ Sbjct: 362 PNAPLTRAELCRQIQGLLNPNTTLIAETGDSWFNAMRMKLPHGARVELEMQWGHIGWSVP 421 Query: 421 ATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLI 480 AT G A A +P++R +L +GDGS QLT QE++ M+R L +F++NN GYTIE I Sbjct: 422 ATFGYAVA----EPERRNVLMVGDGSFQLTAQEVAQMVRRKLPIIIFLINNRGYTIEVKI 477 Query: 481 HGPKAQYNEIQGWDHLSLLPTFGAKDYETHRV-ATTGEWDKLTQDKSFNDNSKIRMIEIM 539 H YN I+ WD+ L+ F A+D + + ATTG K+ +IE + Sbjct: 478 H--DGPYNNIKNWDYAGLMEVFNAEDGKGLGLKATTGGELAEAIKKALAHREGPTLIECV 535 Query: 540 LPVFDAPQNLVEQAKLTAATNAK 562 + D LV K A NA+ Sbjct: 536 IDRDDCTPELVTWGKKVATANAR 558 >2VBI-A nrPDB Length = 566 Score = 566 bits (1457), Expect = e-161, Method: Composition-based stats. Identities = 165/563 (29%), Positives = 279/563 (49%), Gaps = 14/563 (2%) Query: 4 ITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYAR 63 T+G YL ERL Q+ + F + GD+NL LLD++ + M+ NELN ++A+GYAR Sbjct: 3 YTVGMYLAERLVQIGLKHHFAVAGDYNLVLLDQLLLNKDMKQIYCCNELNCGFSAEGYAR 62 Query: 64 IKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFT 123 G + + TF VG +SA+N + G+YAE++ V+ + G P+ + Q +LHHT+G D++ Sbjct: 63 SNGAAAAVVTFSVGAISAMNALGGAYAENLPVILISGAPNSNDQGTGHILHHTIGKTDYS 122 Query: 124 VFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLLQT 183 M+ ++ ITD +APA+ID IRT ++P YL + N+ + Sbjct: 123 YQLEMARQVTCAAESITDAHSAPAKIDHVIRTALRERKPAYLDIACNIASEPC---VRPG 179 Query: 184 PIDMSLKPN--DAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFP 241 P+ L D S K +D +AL++ + +PV+L + + A T+ L D Q Sbjct: 180 PVSSLLSEPEIDHTSLKAAVDATVALLEKSASPVMLLGSKLRAANALAATETLADKLQCA 239 Query: 242 AFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYSY 301 + KG E H + G+Y G +S P V+E VE++D +L + + +D++T +S Sbjct: 240 VTIMAAAKGFFPEDHAGFRGLYWGEVSNPGVQELVETSDALLCIAPVFNDYSTVGWSAWP 299 Query: 302 KTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANAAVPA 361 K N++ D + + + G ++ LQ L + +VP + A Sbjct: 300 KGPNVILAEPDRVTVDGRAYDGFTLRAFLQALAEKAPARPASAQKSSVPTCSLT--ATSD 357 Query: 362 STPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTGA 421 L + + + L ++AETG S F + T P ++ WG IG++ + Sbjct: 358 EAGLTNDEIVRHINALLTSNTTLVAETGDSWFNAMRMTLPRGARVELEMQWGHIGWSVPS 417 Query: 422 TLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLIH 481 G A ++ ++ ++ +GDGS QLT QE++ M+R+ L +F++NN GY IE IH Sbjct: 418 AFGNAMGSQ----DRQHVVMVGDGSFQLTAQEVAQMVRYELPVIIFLINNRGYVIEIAIH 473 Query: 482 GPKAQYNEIQGWDHLSLLPTFGAKDYETHRV-ATTGEWDKLTQDKSFNDNSKIRMIEIML 540 YN I+ WD+ L+ F A + + ATT + ++ + +IE + Sbjct: 474 --DGPYNYIKNWDYAGLMEVFNAGEGHGLGLKATTPKELTEAIARAKANTRGPTLIECQI 531 Query: 541 PVFDAPQNLVEQAKLTAATNAKQ 563 D LV+ + A+TNA++ Sbjct: 532 DRTDCTDMLVQWGRKVASTNARK 554 >5EUJ-A nrPDB Length = 573 Score = 552 bits (1421), Expect = e-157, Method: Composition-based stats. Identities = 162/564 (28%), Positives = 270/564 (47%), Gaps = 14/564 (2%) Query: 3 EITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYA 62 T+G YL ERL Q+ + F + GD+NL LLD++ + M NELN ++A+GYA Sbjct: 1 MYTVGMYLAERLAQIGLKHHFAVAGDYNLVLLDQLLLNKDMEQVYCCNELNCGFSAEGYA 60 Query: 63 RIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDF 122 R +G + I TF VG +SA+N I G+YAE++ V+ + G P+ + +LHHT+G D+ Sbjct: 61 RARGAAAAIVTFSVGAISAMNAIGGAYAENLPVILISGSPNTNDYGTGHILHHTIGTTDY 120 Query: 123 TVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLLQ 182 M +++ I APA+ID IRT ++P YL + N+ + Sbjct: 121 NYQLEMVKHVTCAAESIVSAEEAPAKIDHVIRTALRERKPAYLEIACNVAGAEC---VRP 177 Query: 183 TPIDMSLK--PNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQF 240 PI+ L+ D S +D + ++D +N V+L + + + L D Sbjct: 178 GPINSLLRELEVDQTSVTAAVDAAVEWLQDRQNVVMLVGSKLRAAAAEKQAVALADRLGC 237 Query: 241 PAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYS 300 + KG E HP + G+Y G +S +E VE+AD IL + + +D+ T ++ Sbjct: 238 AVTIMAAAKGFFPEDHPNFRGLYWGEVSSEGAQELVENADAILCLAPVFNDYATVGWNSW 297 Query: 301 YKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANAAVP 360 K N++ +D + +F G+ + L + P A Sbjct: 298 PKGDNVMVMDTDRVTFAGQSFEGLSLSTFAAALAEKAPSRPATTQGTQAP--VLGIEAAE 355 Query: 361 ASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTG 420 + PL + M Q+ + + + AETG S F ++ P ++ WG IG++ Sbjct: 356 PNAPLTNDEMTRQIQSLITSDTTLTAETGDSWFNASRMPIPGGARVELEMQWGHIGWSVP 415 Query: 421 ATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLI 480 + G A + P++R I+ +GDGS QLT QE++ MIR+ + +F++NN GY IE I Sbjct: 416 SAFGNAVGS----PERRHIMMVGDGSFQLTAQEVAQMIRYEIPVIIFLINNRGYVIEIAI 471 Query: 481 HGPKAQYNEIQGWDHLSLLPTFGAKDYETHRV-ATTGEWDKLTQDKSFNDNSKIRMIEIM 539 H YN I+ W++ L+ F +D + A+TG + K+ ++ +IE Sbjct: 472 H--DGPYNYIKNWNYAGLIDVFNDEDGHGLGLKASTGAELEGAIKKALDNRRGPTLIECN 529 Query: 540 LPVFDAPQNLVEQAKLTAATNAKQ 563 + D + L+ K AATN+++ Sbjct: 530 IAQDDCTETLIAWGKRVAATNSRK 553 >2VBF-A nrPDB Length = 570 Score = 547 bits (1410), Expect = e-156, Method: Composition-based stats. Identities = 204/560 (36%), Positives = 306/560 (54%), Gaps = 14/560 (2%) Query: 2 SEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGY 61 S T+G YL +RL ++ + +FG+PGD+NL LD+I E M+W GNANELNA+Y ADGY Sbjct: 23 SMYTVGDYLLDRLHELGIEEIFGVPGDYNLQFLDQIISREDMKWIGNANELNASYMADGY 82 Query: 62 ARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGD 121 AR K + +TTFGVGELSA+NG+AGSYAE++ V+ +VG P+ Q +HHTL +GD Sbjct: 83 ARTKKAAAFLTTFGVGELSAINGLAGSYAENLPVVEIVGSPTSKVQNDGKFVHHTLADGD 142 Query: 122 FTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLL 181 F F +M ++ ++T A EIDR + ++PVY+ LP ++ L Sbjct: 143 FKHFMKMHEPVTAARTLLT-AENATYEIDRVLSQLLKERKPVYINLPVDVAAAKAEKPAL 201 Query: 182 QTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFP 241 + S +E+ ++ I +K+A+ PV++A ++ + + T+ P Sbjct: 202 SLEKESSTT---NTTEQVILSKIEESLKNAQKPVVIAGHEVISFGLEKTVTQFVSETKLP 258 Query: 242 AFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYSY 301 GK ++DE P + G+Y G LS+ +K VESAD IL +G L+D +TG+F++ Sbjct: 259 ITTLNFGKSAVDESLPSFLGIYNGKLSEISLKNFVESADFILMLGVKLTDSSTGAFTHHL 318 Query: 302 KTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANAAVPA 361 ++ + D I N + V+ L KG + +P+ Sbjct: 319 DENKMISLNIDEGIIFNKVVEDFDFRAVVSSLSE-----LKGIEYEGQYIDKQYEEFIPS 373 Query: 362 STPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTGA 421 S PL Q+ +W + + Q + ++AE GTS FG + +N+ I Q LWGSIG+T A Sbjct: 374 SAPLSQDRLWQAVESLTQSNETIVAEQGTSFFGASTIFLKSNSRFIGQPLWGSIGYTFPA 433 Query: 422 TLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLIH 481 LG+ A D + R +LFIGDGSLQLTVQE+ IR L P F++NNDGYT+E+ IH Sbjct: 434 ALGSQIA----DKESRHLLFIGDGSLQLTVQELGLSIREKLNPICFIINNDGYTVEREIH 489 Query: 482 GPKAQYNEIQGWDHLSLLPTFGA-KDYETHRVATTGEWDKLTQDKSFNDNSKIRMIEIML 540 GP YN+I W++ L TFGA +D ++ T ++ D +++ IE++L Sbjct: 490 GPTQSYNDIPMWNYSKLPETFGATEDRVVSKIVRTENEFVSVMKEAQADVNRMYWIELVL 549 Query: 541 PVFDAPQNLVEQAKLTAATN 560 DAP+ L + KL A N Sbjct: 550 EKEDAPKLLKKMGKLFAEQN 569 >4ZP1-A nrPDB Length = 568 Score = 528 bits (1360), Expect = e-150, Method: Composition-based stats. Identities = 164/568 (28%), Positives = 264/568 (46%), Gaps = 16/568 (2%) Query: 4 ITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYAR 63 T+G YL ERL Q+ + F + GD+NL LLD + + M NELN ++A+GYAR Sbjct: 3 YTVGTYLAERLVQIGLKHHFAVAGDYNLVLLDNLLLNKNMEQVYCCNELNCGFSAEGYAR 62 Query: 64 IKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFT 123 KG + + T+ VG LSA + I G+YAE++ V+ + G P+ + A +LHH LG D+ Sbjct: 63 AKGAAAAVVTYSVGALSAFDAIGGAYAENLPVILISGAPNNNDHAAGHVLHHALGKTDYH 122 Query: 124 VFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLLQT 183 M+ NI+ I APA+ID I+T ++PVYL + N+ + A + Sbjct: 123 YQLEMAKNITAAAEAIYTPEEAPAKIDHVIKTALREKKPVYLEIACNIASMPCAAPGPAS 182 Query: 184 PIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFPAF 243 + + + +D S ++ L + + +L + + K D Sbjct: 183 AL-FNDEASDEASLNAAVEETLKFIANRDKVAVLVGSKLRAAGAEEAAVKFADALGGAVA 241 Query: 244 VTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYSYKT 303 K E++P Y G G +S P V++ ++ AD ++++ + +D++T ++ Sbjct: 242 TMAAAKSFFPEENPHYIGTSWGEVSYPGVEKTMKEADAVIALAPVFNDYSTTGWTDIPDP 301 Query: 304 KNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANAAVPA-- 361 K +V + + FP V +K L +L ++ A PA Sbjct: 302 KKLVLAEPRSVVVNGIRFPSVHLKDYLTRLAQKVSKKTGALDFFKSLNAGELKKAAPADP 361 Query: 362 STPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTGA 421 S PL + Q+ L VIAETG S F + PN ++ WG IG++ A Sbjct: 362 SAPLVNAEIARQVEALLTPNTTVIAETGDSWFNAQRMKLPNGARVEYEMQWGHIGWSVPA 421 Query: 422 TLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLIH 481 G A A P++R IL +GDGS QLT QE++ M+R L +F++NN GYTI +IH Sbjct: 422 AFGYAVGA----PERRNILMVGDGSFQLTAQEVAQMVRLKLPVIIFLINNYGYTIAVMIH 477 Query: 482 GPKAQYNEIQGWDHLSLLPTFGAKD------YETHRVATTGEWDKLTQDKSFNDNSKIRM 535 YN I+ WD+ L+ F + + T GE + + N + + Sbjct: 478 --DGPYNNIKNWDYAGLMEVFNGNGGYDSGAGKGLKAKTGGELAEAIKVALANTDGPT-L 534 Query: 536 IEIMLPVFDAPQNLVEQAKLTAATNAKQ 563 IE + D + LV+ K AA N+++ Sbjct: 535 IECFIGREDCTEELVKWGKRVAAANSRK 562 >4COK-A nrPDB Length = 558 Score = 526 bits (1355), Expect = e-150, Method: Composition-based stats. Identities = 167/554 (30%), Positives = 260/554 (46%), Gaps = 10/554 (1%) Query: 4 ITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYAR 63 T+G+YL +RL Q+ + F + GD+NL LLD++ M+ +NELN ++A+GYAR Sbjct: 3 YTVGRYLADRLAQIGLKHHFAVAGDYNLVLLDQLLLNTDMQQIYCSNELNCGFSAEGYAR 62 Query: 64 IKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFT 123 G + I TF VG LSA N + G+YAE++ V+ + G P+ + +LHHTLG D+ Sbjct: 63 ANGAAAAIVTFSVGALSAFNALGGAYAENLPVILISGAPNANDHGTGHILHHTLGTTDYG 122 Query: 124 VFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLLQT 183 M+ +I+ I APA+ID IRT ++P YL + N+ Sbjct: 123 YQLEMARHITCAAESIVAAEDAPAKIDHVIRTALREKKPAYLEIACNVAGAPCVRPGGID 182 Query: 184 PIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFPAF 243 + P D S K +D LA ++ + +L + +A+ L D Sbjct: 183 ALLSPPAP-DEASLKAAVDAALAFIEQRGSVTMLVGSRIRAAGAQAQAVALADALGCAVT 241 Query: 244 VTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYSYKT 303 K E HP Y G Y G +S P ++AVE AD ++ + + +D+ T +S K Sbjct: 242 TMAAAKSFFPEDHPGYRGHYWGEVSSPGAQQAVEGADGVICLAPVFNDYATVGWSAWPKG 301 Query: 304 KNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANAAVPAST 363 N++ + + + G+ M+ L +L + A TP A + Sbjct: 302 DNVMLVERHAVTVGGVAYAGIDMRDFLTRLAAHTVRRDATARGGAYV--TPQTPAAAPTA 359 Query: 364 PLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTGATL 423 PL M Q+G L + AETG S F + P+ ++ WG IG++ A Sbjct: 360 PLNNAEMARQIGALLTPRTTLTAETGDSWFNAVRMKLPHGARVELEMQWGHIGWSVPAAF 419 Query: 424 GAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLIHGP 483 G A AA P+++ +L +GDGS QLT QE++ MIR L +F++NN GYTIE +IH Sbjct: 420 GNALAA----PERQHVLMVGDGSFQLTAQEVAQMIRHDLPVIIFLINNHGYTIEVMIH-- 473 Query: 484 KAQYNEIQGWDHLSLLPTFGAKDYETHRVA-TTGEWDKLTQDKSFNDNSKIRMIEIMLPV 542 YN ++ WD+ L+ F A + + TG +++ + + +IE L Sbjct: 474 DGPYNNVKNWDYAGLMEVFNAGEGNGLGLRARTGGELAAAIEQARANRNGPTLIECTLDR 533 Query: 543 FDAPQNLVEQAKLT 556 D Q LV K Sbjct: 534 DDCTQELVTWGKRV 547 >1OVM-A nrPDB Length = 552 Score = 523 bits (1347), Expect = e-149, Method: Composition-based stats. Identities = 209/567 (36%), Positives = 305/567 (53%), Gaps = 27/567 (4%) Query: 2 SEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGY 61 + + YL +RL + +FG+PGD+NL LD + + + W G ANELNA+YAADGY Sbjct: 3 TPYCVADYLLDRLTDCGADHLFGVPGDYNLQFLDHVIDSPDICWVGCANELNASYAADGY 62 Query: 62 ARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGD 121 AR KG + ++TTFGVGELSA+NGIAGSYAEHV VLH+VG P +AQ + LLHHTLG+G+ Sbjct: 63 ARCKGFAALLTTFGVGELSAMNGIAGSYAEHVPVLHIVGAPGTAAQQRGELLHHTLGDGE 122 Query: 122 FTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLL 181 F F+ MS I+ A++T+ A EIDR + T +RP YL LPA++ AK Sbjct: 123 FRHFYHMSEPITVAQAVLTE-QNACYEIDRVLTTMLRERRPGYLMLPADV------AKKA 175 Query: 182 QTPIDMSLKPNDAESEKEVI----DTILALVKDAKNPVILADACCSRHDVKAETKKLIDL 237 TP +L A ++ + D + +K +LAD RH +K +K + Sbjct: 176 ATPPVNALTHKQAHADSACLKAFRDAAENKLAMSKRTALLADFLVLRHGLKHALQKWVKE 235 Query: 238 TQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSF 297 MGKG DE+ + G Y G+ S VKEA+E AD +L VG +D T F Sbjct: 236 VPMAHATMLMGKGIFDERQAGFYGTYSGSASTGAVKEAIEGADTVLCVGTRFTDTLTAGF 295 Query: 298 SYSYKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANA 357 ++ +E ++ + F G+ M + + T+ + K + V + ++ Sbjct: 296 THQLTPAQTIEVQPHAARVGDVWFTGIPMN----QAIETLVELCKQH--VHAGLMSSSSG 349 Query: 358 AVPASTP---LKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGS 414 A+P P L QE W L F++ GD+++A+ GTSAFG P + I Q LWGS Sbjct: 350 AIPFPQPDGSLTQENFWRTLQTFIRPGDIILADQGTSAFGAIDLRLPADVNFIVQPLWGS 409 Query: 415 IGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGY 474 IG+T A GA A P +RVI+ GDG+ QLT+QE+ +M+R P + VLNN+GY Sbjct: 410 IGYTLAAAFGAQTA----CPNRRVIVLTGDGAAQLTIQELGSMLRDKQHPIILVLNNEGY 465 Query: 475 TIEKLIHGPKAQYNEIQGWDHLSLLPTFGAK-DYETHRVATTGEWDKLTQDKSFNDNSKI 533 T+E+ IHG + +YN+I W+ + E RV+ + + + + ++ ++ Sbjct: 466 TVERAIHGAEQRYNDIALWNWTHIPQALSLDPQSECWRVSEAEQLADVLEKVAHHE--RL 523 Query: 534 RMIEIMLPVFDAPQNLVEQAKLTAATN 560 +IE+MLP D P L K A N Sbjct: 524 SLIEVMLPKADIPPLLGALTKALEACN 550 >2Q5O-A nrPDB Length = 565 Score = 408 bits (1047), Expect = e-114, Method: Composition-based stats. Identities = 137/552 (24%), Positives = 234/552 (42%), Gaps = 25/552 (4%) Query: 2 SEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGY 61 S + L + L LK +FG+PGDF L E + + ++E +AAD Sbjct: 19 SHMKLAEALLRALKDRGAQAMFGIPGDFALPFFKVAEETQILPLHTLSHEPAVGFAADAA 78 Query: 62 ARIKG-MSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNG 120 AR + T+G G + +N +AG+YAE V+ + G P + LLLHH Sbjct: 79 ARYSSTLGVAAVTYGAGAFNMVNAVAGAYAEKSPVVVISGAPGTTEGNAGLLLHHQGRTL 138 Query: 121 DFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKL 180 D ++ I+ A + D A APAEI R + RPVYL +P N+V+ V Sbjct: 139 D--TQFQVFKEITVAQARLDDPAKAPAEIARVLGAARAQSRPVYLEIPRNMVNAEVEPV- 195 Query: 181 LQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQF 240 D P D ++ D +LA ++ A +PV++ R+ ++A+ +L Sbjct: 196 ----GDDPAWPVDRDALAACADEVLAAMRSATSPVLMVCVEVRRYGLEAKVAELAQRLGV 251 Query: 241 PAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYS 300 P T MG+G + + G Y+G E+ VE +D + +GA+LSD N Sbjct: 252 PVVTTFMGRGLLADAPTPPLGTYIGVAGDAEITRLVEESDGLFLLGAILSDTNFAVSQRK 311 Query: 301 YKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADA---AKGYKPVAVPARTPANA 357 + + + + T+ + + ++ LL + + +G +P A P A+ Sbjct: 312 IDLRKTIHAFDRAVTLGYHTYADIPLAGLVDALLERLPPSDRTTRGKEPHAYPTGLQADG 371 Query: 358 AVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGF 417 A P+ N QE ++ A+ G F + ++ + +GF Sbjct: 372 EPIA--PMDIARAVNDRVRAGQEPLLIAADMGDCLFTAMDMI---DAGLMAPGYYAGMGF 426 Query: 418 TTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIE 477 A +GA + KR++ +GDG+ Q+T E+ R G+ P + + NN + + Sbjct: 427 GVPAGIGAQ----CVSGGKRILTVVGDGAFQMTGWELGNCRRLGIDPIVILFNNASWEML 482 Query: 478 KLIHGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSFNDNSKIRMIE 537 + P++ +N++ W + G + RV T E K DK+F + ++IE Sbjct: 483 RTFQ-PESAFNDLDDWRFADMAAGMGG---DGVRVRTRAEL-KAALDKAFATRGRFQLIE 537 Query: 538 IMLPVFDAPQNL 549 M+P L Sbjct: 538 AMIPRGVLSDTL 549 >1T9B-A nrPDB Length = 677 Score = 376 bits (965), Expect = e-104, Method: Composition-based stats. Identities = 132/595 (22%), Positives = 228/595 (38%), Gaps = 73/595 (12%) Query: 4 ITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYAR 63 +T G+ E + + NV+TVFG PG L + D I+ + + +E A + A+GYAR Sbjct: 82 LTGGQIFNEMMSRQNVDTVFGYPGGAILPVYDAIHNSDKFNFVLPKHEQGAGHMAEGYAR 141 Query: 64 IKGMS-CIITTFGVGELSALNGIAGSYAEHVGVLHVVG-VPSISAQAKQLLLHHTLGNGD 121 G ++ T G G + + +A ++A+ + ++ G VP+ + +G Sbjct: 142 ASGKPGVVLVTSGPGATNVVTPMADAFADGIPMVVFTGQVPTSAIGTDAFQEADVVG--- 198 Query: 122 FTVFHRMSANISETTAMITDIATAPAEIDRCIRTT-YVTQRPVYLGLPANLVDLNVPAKL 180 +S + ++ M+ + P I+ PV + LP + V A + Sbjct: 199 ------ISRSCTKWNVMVKSVEELPLRINEAFEIATSGRPGPVLVDLPKD-----VTAAI 247 Query: 181 LQTPIDMSLK-PNDA----------ESEKEVIDTILALVKDAKNPVILADACCSRH-DVK 228 L+ PI P++A E + I+ L+ AK PV+ A H D Sbjct: 248 LRNPIPTKTTLPSNALNQLTSRAQDEFVMQSINKAADLINLAKKPVLYVGAGILNHADGP 307 Query: 229 AETKKLIDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGAL 288 K+L D Q P T G GS D++ P+ + +G AV++ADLI++VGA Sbjct: 308 RLLKELSDRAQIPVTTTLQGLGSFDQEDPKSLDM-LGMHGCATANLAVQNADLIIAVGAR 366 Query: 289 LSDFNTGSFS-------------------YSYKTKNIVEFHSDHMKIRNATFPGV----Q 325 D TG+ S + KNI + + + + Sbjct: 367 FDDRVTGNISKFAPEARRAAAEGRGGIIHFEVSPKNINKVVQTQIAVEGDATTNLGKMMS 426 Query: 326 MKFVLQKLLTTIADAAKGYK--PVAVPARTPANAAVPASTPLKQEWMWNQLGNFLQEGDV 383 F +++ A K K P A TP + P + K + N G + + Sbjct: 427 KIFPVKERSEWFAQINKWKKEYPYAYMEETPGSKIKPQTVIKKLSKVANDTGRHV----I 482 Query: 384 VIAETGTSAFGIN-QTTFPNNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFI 442 V G T+ N I+ G++G+ A +GA A P+ VI Sbjct: 483 VTTGVGQHQMWAAQHWTWRNPHTFITSGGLGTMGYGLPAAIGAQVA----KPESLVIDID 538 Query: 443 GDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTI----EKLIHGPKAQYNEIQGWDHLSL 498 GD S +T+ E+S+ ++ G + +LNN+ + + L + + + D + L Sbjct: 539 GDASFNMTLTELSSAVQAGTPVKILILNNEEQGMVTQWQSLFYEHRYSHTHQLNPDFIKL 598 Query: 499 LPTFGAKDYETHRVATTGEWDKLTQDKSFNDNSKIRMIEIMLPVFDAPQNLVEQA 553 G K RV E D ++ F ++E+ + +V Sbjct: 599 AEAMGLK---GLRVKKQEELDAKLKE--FVSTKGPVLLEVEVDKKVPVLPMVAGG 648 >6DEO-A nrPDB Length = 682 Score = 371 bits (952), Expect = e-103, Method: Composition-based stats. Identities = 122/596 (20%), Positives = 224/596 (37%), Gaps = 69/596 (11%) Query: 4 ITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYAR 63 +T G+ E + + V+TVFG G L + D IY + ++ +E A + A+GYAR Sbjct: 87 LTGGEIFHEMMLRHKVDTVFGYAGGAILPVFDAIYNSDKFKFVLPRHEQGAGHMAEGYAR 146 Query: 64 IKGMS-CIITTFGVGELSALNGIAGSYAEHVGVLHVVG-VPSISAQAKQLLLHHTLGNGD 121 G ++ T G G + + +A + + V ++ G VP+ + +G Sbjct: 147 ASGKPGVVLVTSGPGATNVITPMADALMDGVPLVVFSGQVPTTAIGTDAFQEADIVG--- 203 Query: 122 FTVFHRMSANISETTAMITDIATAPAEIDRCIRTT-YVTQRPVYLGLPANLV------DL 174 +S + ++ M+ ++A P I+ PV + LP ++ + Sbjct: 204 ------ISRSCTKWNVMVKNVAELPRRINEAFEIATTGRPGPVLVDLPKDVTASILRESI 257 Query: 175 NVPAKLLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRH-DVKAETKK 233 + L + K +E E I ++ AK P+I A A + K+ Sbjct: 258 PINTTLPSNALSQITKKAVSEFTSEAIKRAANILNKAKKPIIYAGAGILNNEQGPKLLKE 317 Query: 234 LIDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFN 293 L D P T G G+ D++ P+ + +G A+++AD I+++GA D Sbjct: 318 LADKANIPVTTTLQGLGAFDQRDPKSLDM-LGMHGSAAANTAIQNADCIIALGARFDDRV 376 Query: 294 TGSFS-------------------YSYKTKNIVEFHSDHMKIRNATFPGVQMKFVL---- 330 TG+ S + KNI + I +Q L Sbjct: 377 TGNISKFAPEAKLAASEGRGGILHFEISPKNINKVVEATEAIEGDVTANLQSFIPLVDSI 436 Query: 331 ---QKLLTTIADAAKGYKPVAVPARTPANAAVPASTPLKQEWMWNQLGNFLQEGDVVIAE 387 + I + K Y P + TP + P + + + +Q + +E VI Sbjct: 437 ENRPEWFNKINEWKKKY-PYSYQLETPGSLIKPQTL---IKEISDQAQTYNKE---VIVT 489 Query: 388 TGTSAFGINQTTFPNNTYG---ISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGD 444 TG + T I+ G++G+ A +GA A P VI GD Sbjct: 490 TGVGQHQMWAAQHFTWTQPRTMITSGGLGTMGYGLPAAIGAQVA----KPDAIVIDIDGD 545 Query: 445 GSLQLTVQEISTMIRWGLKPYLFVLNNDGYTI----EKLIHGPKAQYNEIQGWDHLSLLP 500 S +T+ E+S+ ++ G + VLNN+ + + L + + + D + L Sbjct: 546 ASFNMTLTELSSAVQAGAPIKVCVLNNEEQGMVTQWQSLFYEHRYSHTHQSNPDFMKLAE 605 Query: 501 TFGAKDYETHRVATTGEWDKLTQDKSFNDNSKIRMIEIMLPVFDAPQNLVEQAKLT 556 + K R+ E ++ F D ++ ++E+++ +V K Sbjct: 606 SMNVK---GIRITNQQELKSGVKE--FLDATEPVLLEVIVEKKVPVLPMVPAGKAL 656 >4QQ8-A nrPDB Length = 583 Score = 364 bits (935), Expect = e-101, Method: Composition-based stats. Identities = 123/580 (21%), Positives = 215/580 (37%), Gaps = 49/580 (8%) Query: 1 MSEITLGKYLFERLKQVNVNTVFGLPG----DFNLSLLDKIYEVEGMRWAGNANELNAAY 56 M+ IT G+ + L + V +FGL G + LD + R A Y Sbjct: 1 MAMITGGELVVRTLIKAGVEHLFGLHGIHIDTIFQACLDHDVPIIDTRHEAAAGHAAEGY 60 Query: 57 AADGYARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHT 116 A G + + T G G +A+ IA + + VL + G ++ +T Sbjct: 61 ARAGA----KLGVALVTAGGGFTNAVTPIANARTDRTPVLFLTGSGALRDDET-----NT 111 Query: 117 LGNGDFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQR-PVYLGLPANLVDLN 175 L G V M+A I++ + P + + IR R PV L LP +++ Sbjct: 112 LQAGIDQV--AMAAPITKWAHRVMATEHIPRLVMQAIRAALSAPRGPVLLDLPWDILMNQ 169 Query: 176 VPAKLLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLI 235 + + P D+ L + A + +D LAL++ A+ PVI+ + SR K + Sbjct: 170 IDEDSVIIP-DLVLSAHGAHPDPADLDQALALLRKAERPVIVLGSEASRTARKTALSAFV 228 Query: 236 DLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLS-DFNT 294 T P F G + G V L +A + DL+L +GA + Sbjct: 229 AATGVPVFADYEGLSMLSGLPDAMRGGLVQNLY--SFAKADAAPDLVLMLGARFGLNTGH 286 Query: 295 GSFSYSYKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTP 354 GS + +++ D ++ G+ + V T A A + A P R Sbjct: 287 GSGQLIPHSAQVIQVDPDACELGR--LQGIALGIVADVGGTIEALAQATAQDAAWPDRGD 344 Query: 355 ANAAVP---------------ASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTT 399 A V + L + + G V+A+ G + +++ Sbjct: 345 WCAKVTDLAQERYASIAAKSSSEHALHPFHASQVIAKHVDAGVTVVADGGLTYLWLSEVM 404 Query: 400 FPNNT-YGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMI 458 + S+G G LGA A +++ +R IL GDGS+ ++ E T++ Sbjct: 405 SRVKPGGFLCHGYLNSMGVGFGTALGAQVA--DLEAGRRTILVTGDGSVGYSIGEFDTLV 462 Query: 459 RWGLKPYLFVLNNDGYT----IEKLIHGP-KAQYNEIQGWDHLSLLPTFGAKDYETHRVA 513 R L + ++NN + ++L GP + ++ + + FGA Y V Sbjct: 463 RKQLPLIVIIMNNQSWGWTLHFQQLAVGPNRVTGTRLENGSYHGVAAAFGADGYHVDSVE 522 Query: 514 TTGEWDKLTQDKSFNDNSKIRMIEIMLPVFDAPQNLVEQA 553 + L Q + N + I + + P+ P+ L+ Sbjct: 523 SFSA--ALAQALAHNRPACINVAVALDPI--PPEELILIG 558 >2PAN-A nrPDB Length = 616 Score = 360 bits (923), Expect = 1e-99, Method: Composition-based stats. Identities = 99/575 (17%), Positives = 206/575 (35%), Gaps = 51/575 (8%) Query: 1 MSEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADG 60 M+++ L++ + T FG+PG + + G+R + A++ A+G Sbjct: 24 MAKMRAVDAAMYVLEKEGITTAFGVPGAAINPFYSAMRKHGGIRHILARHVEGASHMAEG 83 Query: 61 YARIKG--MSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLG 118 Y R + + T G + + + A+ + +L + G QA + LH Sbjct: 84 YTRATAGNIGVCLGTSGPAGTDMITALYSASADSIPILCITG------QAPRARLHKE-- 135 Query: 119 NGDFTV--FHRMSANISETTAMITDIATAPAEIDRCIRTTY-VTQRPVYLGLPANLVDLN 175 DF ++ +S+ + + A P + + PV + LP ++ Sbjct: 136 --DFQAVDIEAIAKPVSKMAVTVREAALVPRVLQQAFHLMRSGRPGPVLVDLPFDVQVAE 193 Query: 176 VPAKLLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLI 235 + + A S ++ + L++ A+ PVI+A D A ++ Sbjct: 194 IEFD--PDMYEPLPVYKPAASRMQIEKAVEMLIQ-AERPVIVAGGGVINADAAALLQQFA 250 Query: 236 DLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTG 295 +LT P T MG G I + H G+ + + ++D++ +G ++ +TG Sbjct: 251 ELTSVPVIPTLMGWGCIPDDHELMAGMVGLQTAHRYGNATLLASDMVFGIGNRFANRHTG 310 Query: 296 SFSYSYKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKG-YKPVAVPARTP 354 S + + IV + +I P + + + LT + + A+ K +P R Sbjct: 311 SVEKYTEGRKIVHIDIEPTQIGRVLCPDLGIVSDAKAALTLLVEVAQEMQKAGRLPCRKE 370 Query: 355 ANAAVPA------------STPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTF-P 401 A + P+K + ++ ++ + G S Q Sbjct: 371 WVADCQQRKRTLLRKTHFDNVPVKPQRVYEEMNKAFGRDVCYVTTIGLSQIAAAQMLHVF 430 Query: 402 NNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWG 461 + + I+ G +G+T A LG A DPK+ V+ GD Q ++E++ ++ Sbjct: 431 KDRHWINCGQAGPLGWTIPAALGVCAA----DPKRNVVAISGDFDFQFLIEELAVGAQFN 486 Query: 462 LKPYLFVLNND--------------GYTIEKLIHGPKAQYNEIQGWDHLSLLPTFGAKDY 507 + ++NN Y ++ + G DH+ + G K Sbjct: 487 IPYIHVLVNNAYLGLIRQSQRAFDMDYCVQLAFENINSSEVNGYGVDHVKVAEGLGCKAI 546 Query: 508 ETHRVATTGEWDKLTQDKSFNDNSKIRMIEIMLPV 542 + + + + ++E++L Sbjct: 547 RVFKPEDIAPAFEQAKALMAQYRVPV-VVEVILER 580 >5WJ1-A nrPDB Length = 590 Score = 359 bits (922), Expect = 1e-99, Method: Composition-based stats. Identities = 113/494 (22%), Positives = 191/494 (38%), Gaps = 41/494 (8%) Query: 5 TLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARI 64 L E L++ V TVF PG ++ + + +R +E +AA+GYAR Sbjct: 13 KGADILVEALERQGVETVFAYPGGASMEIHQALTRSSSIRNVLPRHEQGGVFAAEGYARS 72 Query: 65 KGMSC-IITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFT 123 G I T G G + ++G+A + + V ++ + G + +G F Sbjct: 73 SGKPGICIATSGPGATNLVSGLADALLDSVPLVAITGQ----------VPRRMIGTDAFQ 122 Query: 124 VFH--RMSANISETTAMITDIATAPAEIDRC-IRTTYVTQRPVYLGLPANLVD---LNVP 177 ++ +I++ ++ D+ P I+ T PV + +P ++ + Sbjct: 123 ETPIVEVTRSITKHNYLVMDVEDIPRIIEEAFFLATSGRPGPVLVDVPKDIQQQLAIPNW 182 Query: 178 AKLLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDL 237 + ++ P MS P E ++ I+ L+ ++K PV+ C E + ++L Sbjct: 183 EQAMRLPGYMSRMPKPPEDSH--LEQIVRLISESKKPVLYVGGGCLNS--SDELGRFVEL 238 Query: 238 TQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSF 297 T P T MG GS +G AVE +DL+L+ G D TG Sbjct: 239 TGIPVASTLMGLGSYPCDDELSL-HMLGMHGTVYANYAVEHSDLLLAFGVRFDDRVTGKL 297 Query: 298 SYSYKTKNIVEFHSDHMKIRNATFPGV----QMKFVLQKLLTTIADAAKGYKPVAVPART 353 IV D +I P V +K LQ + + + A+ K R Sbjct: 298 EAFASRAKIVHIDIDSAEIGKNKTPHVSVCGDVKLALQGMNKVLENRAEELKLDFGVWRN 357 Query: 354 PANA---AVPASTPLKQEWMWNQLG----NFLQEGDVVIAETGTSAFGINQTTFPNN--- 403 N P S E + Q + L +G +I+ TG + F N Sbjct: 358 ELNVQKQKFPLSFKTFGEAIPPQYAIKVLDELTDGKAIIS-TGVGQHQMWAAQFYNYKKP 416 Query: 404 TYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLK 463 +S G++GF A +GA+ A +P V+ GDGS + VQE++T+ L Sbjct: 417 RQWLSSGGLGAMGFGLPAAIGASVA----NPDAIVVDIDGDGSFIMNVQELATIRVENLP 472 Query: 464 PYLFVLNNDGYTIE 477 + +LNN + Sbjct: 473 VKVLLLNNQHLGMV 486 >5AHK-A nrPDB Length = 588 Score = 352 bits (904), Expect = 2e-97, Method: Composition-based stats. Identities = 110/598 (18%), Positives = 203/598 (33%), Gaps = 68/598 (11%) Query: 2 SEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGY 61 S + + + L NV F L G L+D I + + +E AA+AA Sbjct: 19 SHMKASDAVAKILADNNVLYGFELIGGMITHLVDSINLLGKTKLVSMHHEQGAAFAASAV 78 Query: 62 ARI---KGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLG 118 +R+ K + + T G G + + GIA + + + + G + H G Sbjct: 79 SRVTHHKTLGLALATSGPGATNLITGIADCWLDSHPCIFLTGQVNT---------HELKG 129 Query: 119 NGDFTVFHRMSANISETTAMITDIATAPAEIDR------CIRTTYV-----TQRPVYLGL 167 D + ++ A++T I +I C+R PV L + Sbjct: 130 KRD---IRQQGFQELDSVALVTSITKYAYQIKSADELVPCLRKAIQIAKEGRPGPVLLDI 186 Query: 168 PANLVDLNVPAKLLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDV 227 P ++ ++ LL P+ K +D I+ +++AK P++L Sbjct: 187 PMDIQRADIDEALLNNPMTPEPKVQRPSIAMSDLDFIINKLQNAKKPLLLIGGGAVNSSG 246 Query: 228 KAETKKLIDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGA 287 + + I+L P + G I Y G+ +G AV++ DL+L +G+ Sbjct: 247 FQKWLEQIELRGIPYVASLKGAEKIKASD-LYLGM-LGAYGTRAANHAVQNCDLLLVLGS 304 Query: 288 LLSDFNTGSFSYSY-KTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKP 346 + TG+ + + I++ ++ N + L + + + Sbjct: 305 RMDVRQTGAQPEDFARNAEIIQIDLQEGQLNNRVIADFSYQIELSEYFSRFS-------- 356 Query: 347 VAVPARTPANAAVPASTPLKQE------------WMWNQLGNFLQEGDV-------VIAE 387 P + P N T L +E W + G F Q + I + Sbjct: 357 ---PLQIPVNNDWSVWTALLKEKFRVTFIDEYTTWNLSPFGLFTQLNKLTERVALDYILD 413 Query: 388 TGTSAFGINQTTFPNNTYGISQ-VLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGS 446 G + T N + GS+GF A +GA +A KK +I+ GDG Sbjct: 414 VGNNQMWAAHTLRLNAQQAMHHSGGLGSMGFAIPAAIGACYAG-----KKPIIVITGDGG 468 Query: 447 LQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLIHGPKAQY-NEIQGWD-HLSLLPTFGA 504 QL +QE+ + R L V+NN + + + N W+ + S G Sbjct: 469 AQLNIQELDIIARDKLPILTIVMNNHSLGMVRGFQEMYFEGRNSSTYWNGYTSQFKKIGE 528 Query: 505 KDYETHRVATTGEWDKLTQDKSFNDNSKIRMIEIMLPVFDAPQNLVEQAKLTAATNAK 562 + + + + + + M + L E + + + Sbjct: 529 AYRVESKTIISMQAFSSALESFLESPRPLLLEVSMSDARECRPRL-EYGRAIDQQSPR 585 >6A50-A nrPDB Length = 549 Score = 352 bits (902), Expect = 3e-97, Method: Composition-based stats. Identities = 108/551 (19%), Positives = 208/551 (37%), Gaps = 45/551 (8%) Query: 3 EITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYA 62 ++ +E L++ ++TVFG PG L L E R+ E ADGYA Sbjct: 22 MASVHGTTYELLRRQGIDTVFGNPGSNELPFLKDF--PEDFRYILALQEACVVGIADGYA 79 Query: 63 RIKGMSCIITTFGV-GELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLG--N 119 + I G +A+ ++ + H ++ G Q + ++ G N Sbjct: 80 QASRKPAFINLHSAAGTGNAMGALSNARTSHSPLIVTAG------QQTRAMIGVEAGETN 133 Query: 120 GDFTVFHRMSANISETTAMITDIATAPAEIDRCIR-TTYVTQRPVYLGLPANLVDLNVPA 178 D R S A A P + R I + Q PVYL +P + D + Sbjct: 134 VDAANLPRPLVKWSYEPAS---AAEVPHAMSRAIHMASMAPQGPVYLSVPYDDWDKDADP 190 Query: 179 K---LLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLI 235 + L + S++ ND + +D ++ + A NP I+ + A+ L Sbjct: 191 QSHHLFDRHVSSSVRLND-----QDLDILVKALNSASNPAIVLGPDVDAANANADCVMLA 245 Query: 236 DLTQFPAFVTPMG-KGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNT 294 + + P +V P + +HP + G+ + + +E D++L +GA + + Sbjct: 246 ERLKAPVWVAPSAPRCPFPTRHPCFRGLMP--AGIAAISQLLEGHDVVLVIGAPVFRYVF 303 Query: 295 -GSFSYSYKTKNIVEFHSDHMKIRNATFPGVQMKF--VLQKLLTTIADAAKGYKPVAVPA 351 Y ++ D ++ A + + L + + + P A P Sbjct: 304 YDPGQYLKPGTRLISVTCDPLEAARAPMGDAIVADIGAMASALANLVEESSRQLPTAAPE 363 Query: 352 RTPANAAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVL 411 PA A L E +++ L + E + + E+ ++ + Q N Sbjct: 364 --PAKVDQDAGR-LHPETVFDTLNDMAPENAIYLNESTSTTAQMWQRLNMRNPGSYYFCA 420 Query: 412 WGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNN 471 G +GF A +G A +P+++VI IGDGS ++ + T ++ + ++NN Sbjct: 421 AGGLGFALPAAIGVQLA----EPERQVIAVIGDGSANYSISALWTAAQYNIPTIFVIMNN 476 Query: 472 DGYTIEKLIHGPKAQYN----EIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSF 527 Y + + G N ++ G D +L +G + + + E K + ++ Sbjct: 477 GTYGMLRWFAGVLEAENVPGLDVPGIDFRALAKGYGVQALKADNL----EQLKGSLQEAL 532 Query: 528 NDNSKIRMIEI 538 + + +IE+ Sbjct: 533 SAKGPV-LIEV 542 >4Q9D-A nrPDB Length = 545 Score = 337 bits (863), Expect = 9e-93, Method: Composition-based stats. Identities = 111/555 (20%), Positives = 206/555 (37%), Gaps = 45/555 (8%) Query: 5 TLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARI 64 T+ ++ L+++ + TVFG PG S L E + + E +A ADG+A+ Sbjct: 6 TVHDVTYDLLRKLGLTTVFGNPGSTEESFLRDF--PEDFTYVLSLQEASALAMADGFAQA 63 Query: 65 KGMSCIITTF-GVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFT 123 G ++ G +A+ + +Y + ++ G + ++ L N D T Sbjct: 64 TGKPALVNLHTAAGTGNAMGSLVAAYRANTPLIITAGQQTREMS----VVDPYLNNPDAT 119 Query: 124 VFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQ-RPVYLGLPANLVDLNVPAKLLQ 182 + S A PA + PV+L +P + D Sbjct: 120 TMPKPWVKWSYEPAR---AEDVPAAFMQAYAVAMQPPMGPVFLSIPLDDWDKPALGPAAV 176 Query: 183 TPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFPA 242 + + P DAE + + I A AK+P+++ R + + P Sbjct: 177 RSVSTRVAP-DAERLAQFAERINA----AKHPMLVLGPEVDRAGAWDAGIEFAEKLGAPV 231 Query: 243 FVT-PMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDF-NTGSFSYS 300 + + S E HP Y G T++ V++AV + DL++ VGA + + Y Sbjct: 232 HASALPDRMSFPEDHPLYAGPLPMTIA--GVEQAVSAYDLVVVVGAEVFRYYPYVPGEYL 289 Query: 301 YKTKNIVEFHSDH-----MKIRNATFPGVQMKFV-LQKLLTTIADAAKGYKPVAVPARTP 354 + ++++ +D + ++ V + L +L+ T D V Sbjct: 290 PEGTDLLQITADPHRSAVAPVGDSLVGDVGIALSRLTELIDTPDDRVPPKPLVRQR---- 345 Query: 355 ANAAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSA---FGINQTTFPNNTYGISQVL 411 ++ +P++ P+ ++ L N + V+ E+ ++ F TT P + + Sbjct: 346 -HSDIPSTAPMTSNAVYEVLSNVKPDDAAVVMESTSTMLDLFTWLPTTHPASFFATGS-- 402 Query: 412 WGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNN 471 G IG+ A +G A + V+ IGDGS Q ++Q I T + L VL N Sbjct: 403 -GGIGWGVPAAVGIALGDRARGVDRTVVATIGDGSFQYSIQAIWTAAQHKLPIVFVVLRN 461 Query: 472 DGYTIEK----LIHGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSF 527 Y I K L P ++ G D S+ FG + + + + + Sbjct: 462 GEYAILKSFADLEKTPNVPGLQLPGLDISSIAAGFGCRTATV----ESTDMLEAELKTAL 517 Query: 528 NDNSKIRMIEIMLPV 542 + ++ LP Sbjct: 518 QADGPTVLVVPTLPQ 532 >2EZ4-A nrPDB Length = 603 Score = 330 bits (845), Expect = 1e-90, Method: Composition-based stats. Identities = 104/570 (18%), Positives = 210/570 (36%), Gaps = 51/570 (8%) Query: 2 SEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIY-EVEGMRWAGNANELNAAYAADG 60 + I G + + L+ V+ ++G+PG S++D + E + + + +E A AA Sbjct: 9 TNILAGAAVIKVLEAWGVDHLYGIPGGSINSIMDALSAERDRIHYIQVRHEEVGAMAAAA 68 Query: 61 YARIKGM-SCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGN 119 A++ G + G G +NG+ + +HV VL ++G + Sbjct: 69 DAKLTGKIGVCFGSAGPGGTHLMNGLYDAREDHVPVLALIGQFGTTGMN----------- 117 Query: 120 GDFTVFHRMS-----ANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDL 174 F M+ A++++ + AT P ID IR Y Q + +P +L Sbjct: 118 --MDTFQEMNENPIYADVADYNVTAVNAATLPHVIDEAIRRAYAHQGVAVVQIPVDLPWQ 175 Query: 175 NVPAKLLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKL 234 +PA+ + P E + + + + + A+ P+I + E ++L Sbjct: 176 QIPAEDWYASANSYQTPLLPEPDVQAVTRLTQTLLAAERPLIYYGIGARKAG--KELEQL 233 Query: 235 IDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNT 294 + P T KG + +++P Y G KP EA+ AD++L VG +++ Sbjct: 234 SKTLKIPLMSTYPAKGIVADRYPAYLGSANRVAQKP-ANEALAQADVVLFVG---NNYPF 289 Query: 295 GSFSYSYK-TKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPART 353 S ++K T+ ++ D K+ + + QK L I + Sbjct: 290 AEVSKAFKNTRYFLQIDIDPAKLGKRHKTDIAVLADAQKTLAAILAQVSERESTPWWQAN 349 Query: 354 PANAA----------VPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQ--TTFP 401 AN PL+ + + + + + G N+ P Sbjct: 350 LANVKNWRAYLASLEDKQEGPLQAYQVLRAVNKIAEPDAIYSIDVGDINLNANRHLKLTP 409 Query: 402 NNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWG 461 +N + S + T G + A AA+ P+++V GDG +T+Q+++T +++ Sbjct: 410 SNRHITSNLFA-----TMGVGIPGAIAAKLNYPERQVFNLAGDGGASMTMQDLATQVQYH 464 Query: 462 LKPYLFVLNNDGYTIEKLIHGPKAQ----YNEIQGWDHLSLLPTFGAKDYETHRVATTGE 517 L V N Y K Q E D + + + +++ + Sbjct: 465 LPVINVVFTNCQYGWIKDEQEDTNQNDFIGVEFNDIDFSKIADGVHMQAFRVNKIEQLPD 524 Query: 518 WDKLTQDKSFNDNSKIRMIEIMLPVFDAPQ 547 + + + ++ +I+ ++ Sbjct: 525 VFEQAKAIAQHEPV---LIDAVITGDRPLP 551 >2JI6-A nrPDB Length = 568 Score = 322 bits (824), Expect = 3e-88, Method: Composition-based stats. Identities = 127/572 (22%), Positives = 217/572 (37%), Gaps = 62/572 (10%) Query: 3 EITLGKY-LFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGY 61 E+T G + L + LK +++T++G+ G ++ L ++++ +G R+ +E +A YAA Sbjct: 8 ELTDGFHVLIDALKMNDIDTMYGVVG-IPITNLARMWQDDGQRFYSFRHEQHAGYAASIA 66 Query: 62 ARIKGMSCIITT-FGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNG 120 I+G + T G L+ + +A + ++ + G L G Sbjct: 67 GYIEGKPGVCLTVSAPGFLNGVTSLAHATTNCFPMILLSGS--------SEREIVDLQQG 118 Query: 121 DFTVFHRMSANISETTA--MITDIATAPAEIDRCIRTTYVTQRP--VYLGLPANL----V 172 D+ +M+ A I I P I R +RT V+ RP VY+ LPA L + Sbjct: 119 DYEEMDQMNVARPHCKASFRINSIKDIPIGIARAVRTA-VSGRPGGVYVDLPAKLFGQTI 177 Query: 173 DLNVPAKLLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETK 232 + KLL PID + AE + I L+K+AK PVI+ + E + Sbjct: 178 SVEEANKLLFKPIDPAPAQIPAE---DAIARAADLIKNAKRPVIMLGKGAAYAQCDDEIR 234 Query: 233 KLIDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLS-- 290 L++ T P M KG + + HP+ A+ D+ + +GA L+ Sbjct: 235 ALVEETGIPFLPMGMAKGLLPDNHPQSA--------AATRAFALAQCDVCVLIGARLNWL 286 Query: 291 --DFNTGSFSYSYKTKNIVEFHSDHMKIRNATFPGV--QMKFVLQKLLTTIADAAKGYKP 346 ++ K ++ ++ M V +K + L + A K Sbjct: 287 MQHGKGKTWGDELKKYVQIDIQANEMDSNQPIAAPVVGDIKSAVSLLRKALKGAPKADAE 346 Query: 347 --VAVPARTPANAA-----VPASTPLKQEWMWNQLGN----FLQEGDVVIAETGTSAFGI 395 A+ A+ N A + A TP N LG L D+ + G +A Sbjct: 347 WTGALKAKVDGNKAKLAGKMTAETPSGMMNYSNSLGVVRDFMLANPDISLVNEGANALDN 406 Query: 396 NQTT--FPNNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQE 453 + + WG +G G + AA K VI GD + + E Sbjct: 407 TRMIVDMLKPRKRLDSGTWGVMGIGMGYCVAAAAVT-----GKPVIAVEGDSAFGFSGME 461 Query: 454 ISTMIRWGLKPYLFVLNNDG-YTIEKLIHGPKA-QYNEIQGWDHLSLLPTFGAKDYETHR 511 + T+ R+ L + ++NN G Y + P + + ++ FG K Y Sbjct: 462 LETICRYNLPVTVIIMNNGGIYKGNEADPQPGVISCTRLTRGRYDMMMEAFGGKGY---- 517 Query: 512 VATTGEWDKLTQDKSFNDNSKIRMIEIMLPVF 543 VA T K +++ K +I M+ Sbjct: 518 VANTPAELKAALEEAVAS-GKPCLINAMIDPD 548 >5D6R-B nrPDB Length = 579 Score = 321 bits (822), Expect = 5e-88, Method: Composition-based stats. Identities = 102/542 (18%), Positives = 203/542 (37%), Gaps = 45/542 (8%) Query: 6 LGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARIK 65 + +L+ V VFG+PG + D + + +R +E NAA+ A RI Sbjct: 33 GADLVVSQLEAQGVRQVFGIPGAKIDKVFDSLLDS-SIRIIPVRHEANAAFMAAAVGRIT 91 Query: 66 GM-SCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTV 124 G + T G G + + G+A + +E V+ + G + +AKQ +H ++ Sbjct: 92 GKAGVALVTSGPGCSNLITGMATANSEGDPVVALGGAVKRADKAKQ--VHQSMDTV---- 145 Query: 125 FHRMSANISETTAMITDIATAPAEIDRCIRTTYV-TQRPVYLGLPANLVDLNVPAKLLQT 183 M + +++ +T + R ++ LP ++VD V K+L Sbjct: 146 --AMFSPVTKYAIEVTAPDALAEVVSNAFRAAEQGRPGSAFVSLPQDVVDGPVSGKVLPA 203 Query: 184 PIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFPAF 243 S P + + ID + L+ AKNP+ L S+ + ++L++ + P Sbjct: 204 ----SGAPQMGAAPDDAIDQVAKLIAQAKNPIFLLGLMASQPENSKALRRLLETSHIPVT 259 Query: 244 VTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSY---- 299 T G++++ + VG + ++ ADL++ +G ++ ++ Sbjct: 260 STYQAAGAVNQDNFSRFAGRVGLFNNQAGDRLLQLADLVICIGYSPVEYEPAMWNSGNAT 319 Query: 300 --------SYKTKNI---VEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVA 348 +Y+ +N VE D N + + VL I + + + Sbjct: 320 LVHIDVLPAYEERNYTPDVELVGDIAGTLNKLAQNIDHRLVLSPQAAEILRDRQHQRELL 379 Query: 349 VPARTPANAAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGIS 408 R A A PL + + + + + + G+ I + + ++ Sbjct: 380 --DRRGAQLNQFALHPL---RIVRAMQDIVNSDVTLTVDMGSFHIWIARYLY---SFRAR 431 Query: 409 QVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFV 468 QV+ + T G L A A ++P+++V+ GDG + E+ T +R + Sbjct: 432 QVMISNGQQTMGVALPWAIGAWLVNPERKVVSVSGDGGFLQSSMELETAVRLKANVLHLI 491 Query: 469 LNNDGYTIEKLIHGPKAQYNEIQG-----WDHLSLLPTFGAKDYETHRVATTGEWDKLTQ 523 ++GY + + K Y + G D + +FGAK + + Sbjct: 492 WVDNGYNMVAIQEEKK--YQRLSGVEFGPMDFKAYAESFGAKGFAVESAEALEPTLRAAM 549 Query: 524 DK 525 D Sbjct: 550 DV 551 >2PGN-A nrPDB Length = 589 Score = 319 bits (817), Expect = 2e-87, Method: Composition-based stats. Identities = 123/580 (21%), Positives = 195/580 (33%), Gaps = 69/580 (11%) Query: 1 MSEITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVE-GMRWAGNANELNAAYAAD 59 M+ + E L++ V G G + + D + G R A EL A+ + Sbjct: 1 MAIKRGADLIVEALEEYGTEQVVGFIGHTSHFVADAFSKSHLGKRVINPATELGGAWMVN 60 Query: 60 GYARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGN 119 GY +K S VG + + ++ A+ ++ H N Sbjct: 61 GYNYVKDRSAA-----VGAWHCVGNL------------LLHAAMQEARTGRIPAVHIGLN 103 Query: 120 GDFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRP--VYLGLPANLVDLNVP 177 D + R A T IA + ++R + V G PA +++P Sbjct: 104 SDGRLAGRSEAAQQVPWQSFTPIARSTQRVERLDKVGEAIHEAFRVAEGHPAGPAYVDIP 163 Query: 178 AKLLQTPID-MSLKPNDAESEKEVIDTILALVKDA-------KNPVILADACCSRHDVKA 229 L ID +L P A K V+ V++A KNPVILA +R Sbjct: 164 FDLTADQIDDKALVPRGATRAKSVLHAPNEDVREAAAQLVAAKNPVILAGGGVARSGGSE 223 Query: 230 ETKKLIDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALL 289 KL ++ P T G G E H G G + + +AD +L +G+ L Sbjct: 224 ALLKLAEMVGVPVVTTSTGAGVFPETHALAMG-SAGFCGWKSANDMMAAADFVLVLGSRL 282 Query: 290 SDFNTGSFSYSYKTKNIVEFHSDHMKIRNATFPGVQM----KFVLQKLLTTIADAAKGYK 345 SD+ Y K V +D + FP + + K +++L+ + G+K Sbjct: 283 SDWGIAQ-GYITKMPKFVHVDTDPAVLGTFYFPLLSVVADAKTFMEQLIEVLP-GTSGFK 340 Query: 346 PVAVPARTPANAAVPASTPLK------------QEWMWNQLGNFL---QEGDVVIAETGT 390 V R A M+ + + D+++ + G Sbjct: 341 AVRYQERENFRQATEFRAAWDGWVREQESGDGMPASMFRAMAEVRKVQRPEDIIVTDIGN 400 Query: 391 SA---FGINQTTFPNNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSL 447 FG P ++ + G +G LGA A +P RV L GDG+L Sbjct: 401 HTLPMFGGAILQRPR--RLVTSMAEGILGCGFPMALGAQLA----EPNSRVFLGTGDGAL 454 Query: 448 QLTVQEISTMIRWGLKPYLFVLNNDGY----TIEKLIHGPKAQYNEIQGWDHLSLLPTFG 503 E + L V N+ Y T+ G + E D + + FG Sbjct: 455 YYHFNEFRVAVEHKLPVITMVFTNESYGANWTLMNHQFGQN-NWTEFMNPDWVGIAKAFG 513 Query: 504 AKDYETHRVATTGEWDKLTQDKSFNDNSKIRMIEIMLPVF 543 A V TG+ Q D+ K +IEI + Sbjct: 514 A---YGESVRETGDIAGALQRAI--DSGKPALIEIPVSKT 548 >3EYA-A nrPDB Length = 549 Score = 309 bits (792), Expect = 2e-84, Method: Composition-based stats. Identities = 104/578 (17%), Positives = 213/578 (36%), Gaps = 59/578 (10%) Query: 5 TLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARI 64 T+ Y+ + L+ V ++G+ GD L D + + + W +E AA+AA A++ Sbjct: 4 TVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQL 63 Query: 65 KG-MSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFT 123 G ++ + G G L +NG+ + HV VL + + +G+G F Sbjct: 64 SGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIA----------AHIPSSEIGSGYFQ 113 Query: 124 VFH--RMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLL 181 H + S +++ P + +R + + + LP ++ P Sbjct: 114 ETHPQELFRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPAPE-GA 172 Query: 182 QTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFP 241 + +P E+E + + L++ + N ++ + C E + + P Sbjct: 173 TMHWYHAPQPV-VTPEEEELRKLAQLLRYSSNIALMCGSGC--AGAHKELVEFAGKIKAP 229 Query: 242 AFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVG------------ALL 289 GK ++ +P G+ G + + +AD ++ +G A + Sbjct: 230 IVHALRGKEHVEYDNPYDVGM-TGLIGFSSGFHTMMNADTLVLLGTQFPYRAFYPTDAKI 288 Query: 290 SDFNTGSFSYSYKTKNIVEFHSDHMKIRNATFPGVQMKF---VLQKLLTTIADAAKGYKP 346 + S +K + D A P V+ K L K L DA KG Sbjct: 289 IQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLD- 347 Query: 347 VAVPARTPANAAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNN-TY 405 + A P+ + +++ Q+ +F + + + GT + N Sbjct: 348 ---------DLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRR 398 Query: 406 GISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPY 465 + GS+ LGA +P+++V+ GDG + + + ++++ L Sbjct: 399 LLGSFNHGSMANAMPQALGAQ----ATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVK 454 Query: 466 LFVLNN---DGYTIEKLIHGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLT 522 + V NN +E G E+ + + G RV E D+ Sbjct: 455 IVVFNNSVLGFVAMEMKAGGYLTDGTELHDTNFARIAEACGIT---GIRVEKASEVDEAL 511 Query: 523 QDKSFNDNSKIRMIEIMLPVFD---APQNLVEQAKLTA 557 Q ++F+ + + ++++++ + PQ +EQAK + Sbjct: 512 Q-RAFSIDGPV-LVDVVVAKEELAIPPQIKLEQAKGFS 547 >2Q28-A nrPDB Length = 564 Score = 273 bits (697), Expect = 2e-73, Method: Composition-based stats. Identities = 110/573 (19%), Positives = 209/573 (36%), Gaps = 57/573 (9%) Query: 3 EITLGKYL-FERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGY 61 ++T G ++ E LKQ N++T++G+ G ++ + + + EG+R+ G +E +A YAA Sbjct: 6 QMTDGMHIIVEALKQNNIDTIYGVVG-IPVTDMARHAQAEGIRYIGFRHEQSAGYAAAAS 64 Query: 62 ARIKGMSCIITT-FGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNG 120 + I T G L+ L +A + ++ + G L G Sbjct: 65 GFLTQKPGICLTVSAPGFLNGLTALANATVNGFPMIMISGS--------SDRAIVDLQQG 116 Query: 121 DFTVFHRMSANISETTA--MITDIATAPAEIDRCIRTTYVTQRP--VYLGLPANLVDLNV 176 D+ +M+A A + + R IR + V+ RP VYL LPAN++ + Sbjct: 117 DYEELDQMNAAKPYAKAAFRVNQPQDLGIALARAIRVS-VSGRPGGVYLDLPANVLAATM 175 Query: 177 PAKLLQTPIDMSLKPNDA--ESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKL 234 T I P+ A K V I L+ A+ P+I+ + + ++ Sbjct: 176 EKDEALTTIVKVENPSPALLPCPKSVTSAIS-LLAKAERPLIILGKGAAYSQADEQLREF 234 Query: 235 IDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNT 294 I+ Q P M KG +++ HP A+ +AD+++ VGA L+ Sbjct: 235 IESAQIPFLPMSMAKGILEDTHPLSA--------AAARSFALANADVVMLVGARLNWLLA 286 Query: 295 GSFSYSYKTKNIVEFHSDHMKIR-NATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPART 353 ++ + +I N + + + +A+ + + R Sbjct: 287 HGKKGWAADTQFIQLDIEPQEIDSNRPIAVPVVGDIASSMQGMLAELKQNTFTTPLVWRD 346 Query: 354 PANAAVPAST------------PLKQEWMWNQLGNFLQEG-DVVIAETGTSAFGINQ--T 398 N + PL + + + L+E D+ + G + + Sbjct: 347 ILNIHKQQNAQKMHEKLSTDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLDNARNII 406 Query: 399 TFPNNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMI 458 + WG +G G +GA+ + V+ GD + + EI T+ Sbjct: 407 DMYKPRRRLDCGTWGVMGIGMGYAIGASVTS-----GSPVVAIEGDSAFGFSGMEIETIC 461 Query: 459 RWGLKPYLFVLNNDG-Y---TIEKLIHGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVAT 514 R+ L + + NN G Y ++ G + + + + L+ F Y V T Sbjct: 462 RYNLPVTIVIFNNGGIYRGDGVDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYN---VTT 518 Query: 515 TGEWDKLTQDKSFNDNSKIRMIEIMLPVFDAPQ 547 T E + K +I +++ + Sbjct: 519 TDELRHALTTGIQSR--KPTIINVVIDPAAGTE 549 >4RJK-A nrPDB Length = 571 Score = 267 bits (683), Expect = 8e-72, Method: Composition-based stats. Identities = 96/560 (17%), Positives = 205/560 (36%), Gaps = 48/560 (8%) Query: 6 LGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARIK 65 + + + L + V VFG+PG ++ D + + +G +E NAA+ A R+ Sbjct: 17 GAELVVDCLVEQGVTHVFGIPGAKIDAVFDAL-QDKGPEIIVARHEQNAAFMAQAVGRLT 75 Query: 66 GMS-CIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTV 124 G ++ T G G + G+ + E V+ + G + + K+ H +L N Sbjct: 76 GKPGVVLVTSGPGASNLATGLLTANTEGDPVVALAGNVIRADRLKR--THQSLDNA---- 129 Query: 125 FHRMSANISETTAMITDIATAPAEIDRCIRTTYV-TQRPVYLGLPANLVDLNVPAKLLQT 183 + I++ + + D+ P + R ++ P ++V+ K ++ Sbjct: 130 --ALFQPITKYSVEVQDVKNIPEAVTNAFRIASAGQAGAAFVSFPQDVVNEVTNTKNVRA 187 Query: 184 PIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFPAF 243 L P ++ I ++ AK PV+L R + +KL+ Q P Sbjct: 188 VAAPKLGPAADDAISAAIAK----IQTAKLPVVLVGMKGGRPEAIKAVRKLLKKVQLPFV 243 Query: 244 VTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSYSYKT 303 T G++ +G +E AD++L++G +++ ++ + Sbjct: 244 ETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLEQADVVLTIGYDPIEYDPKFWNINGD- 302 Query: 304 KNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKG--------------YKPVAV 349 + I+ I +A P +++ + + I A + + Sbjct: 303 RTIIHLDEIIADIDHAYQPDLELIGDIPSTINHIEHDAVKVEFAEREQKILSDLKQYMHE 362 Query: 350 PARTPANAAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQ 409 + PA+ + PL + +L N + + V + G+ A +++ + ++ Sbjct: 363 GEQVPADWKSDRAHPL---EIVKELRNAVDDHVTVTCDIGSHAIWMSRYF--RSYEPLTL 417 Query: 410 VLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVL 469 ++ + T G L A A + P ++V+ GDG + E+ T +R V Sbjct: 418 MISNGMQ-TLGVALPWAIGASLVKPGEKVVSVSGDGGFLFSAMELETAVRLKAPIVHIVW 476 Query: 470 NNDGYTIEKLIHGPKAQYNEIQ-----GWDHLSLLPTFGAKDYETHRVATTGEWDKLTQD 524 N+ Y + +YN D + +FGA RV + + + + Sbjct: 477 NDSTYDMVAFQQ--LKKYNRTSAVDFGNIDIVKYAESFGAT---GLRVESPDQLADVLRQ 531 Query: 525 KSFNDNSKIRMIEIMLPVFD 544 + +I++ + D Sbjct: 532 GMNAE--GPVIIDVPVDYSD 549 >4K9Q-A nrPDB Length = 539 Score = 267 bits (681), Expect = 1e-71, Method: Composition-based stats. Identities = 97/554 (17%), Positives = 193/554 (34%), Gaps = 34/554 (6%) Query: 3 EITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYA 62 T+ + F+ L+++ V TV G PG + L + E + ADG + Sbjct: 1 MRTVKEITFDLLRKLQVTTVVGNPGSTEETFLKDF--PSDFNYVLALQEASVVAIADGLS 58 Query: 63 RIKGMSCIITTF-GVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHT--LGN 119 + I+ G G +A+ + +Y ++ G Q + +L + L N Sbjct: 59 QSLRKPVIVNIHTGAGLGNAMGCLLTAYQNKTPLIITAG------QQTREMLLNEPLLTN 112 Query: 120 GDFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYV-TQRPVYLGLPANLVDLNVPA 178 + + S A P R T Q PV+L LP + + +P Sbjct: 113 IEAINMPKPWVKWSYEPAR---PEDVPGAFMRAYATAMQQPQGPVFLSLPLDDWEKLIPE 169 Query: 179 KLLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLT 238 + + P+ + + + +KNP+++ + +R ++ + Sbjct: 170 VDVARTVSTRQGPDP-----DKVKEFAQRITASKNPLLIYGSDIARSQAWSDGIAFAERL 224 Query: 239 QFPAFVTPMG-KGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNT-GS 296 P + P + E HP + G + +++ ++ DLI+ +GA + + + Sbjct: 225 NAPVWAAPFAERTPFPEDHPLFQGALTSGIG--SLEKQIQGHDLIVVIGAPVFRYYPWIA 282 Query: 297 FSYSYKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPAN 356 + + +++ D A + L+ + + + P R+P Sbjct: 283 GQFIPEGSTLLQVSDDPNMTSKAVVGDSLVSDSKLFLIEALKLIDQ-REKNNTPQRSPMT 341 Query: 357 AAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIG 416 + PL+ + L + V++ E + + N G +G Sbjct: 342 KEDRTAMPLRPHAVLEVLKENSPKEIVLVEECPSIVPLMQDVFRINQPDTFYTFASGGLG 401 Query: 417 FTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTI 476 + A +G A E + V+ +GDGS Q +VQ I T ++ V N+ Y I Sbjct: 402 WDLPAAVGLALGEEVSGRNRPVVTLMGDGSFQYSVQGIYTGVQQKTHVIYVVFQNEEYGI 461 Query: 477 EK----LIHGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSFNDNSK 532 K L P ++ G D ++ +GAK + +V T E + Sbjct: 462 LKQFAELEQTPNVPGLDLPGLDIVAQGKAYGAK---SLKVETLDELKTAYLEAL--SFKG 516 Query: 533 IRMIEIMLPVFDAP 546 +I + + P Sbjct: 517 TSVIVVPITKELKP 530 >1V5E-A nrPDB Length = 590 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 90/563 (15%), Positives = 189/563 (33%), Gaps = 41/563 (7%) Query: 4 ITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEG-MRWAGNANELNAAYAADGYA 62 I +G + + L+ +T++G+P SL+D + E E +++ +E A AA + Sbjct: 4 INIGLAVMKILESWGADTIYGIPSGTLSSLMDAMGEEENNVKFLQVKHEEVGAMAAVMQS 63 Query: 63 RIKG-MSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGD 121 + G + + + G G +NG+ + +++ V+ ++G L Sbjct: 64 KFGGNLGVTVGSGGPGASHLINGLYDAAMDNIPVVAILGS----------RPQRELNMDA 113 Query: 122 FTVFHR--MSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAK 179 F ++ M +I+ + P +D R + L +P + + + Sbjct: 114 FQELNQNPMYDHIAVYNRRVAYAEQLPKLVDEAARMAIAKRGVAVLEVPGDFAKVEIDND 173 Query: 180 LLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQ 239 + + K + ID + L+ ++K PVI A H ++L + Sbjct: 174 QWYSSANSLRKYAPIAPAAQDIDAAVELLNNSKRPVIYAGIGTMGHG--PAVQELARKIK 231 Query: 240 FPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFSY 299 P T + + G + E + AD +L G S+F Sbjct: 232 APVITTGKNFETFEWDFEALTGSTYR-VGWKPANETILEADTVLFAG---SNFPFSEVEG 287 Query: 300 SYKT-KNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPANAA 358 +++ N ++ D + V + + I + + A N A Sbjct: 288 TFRNVDNFIQIDIDPAMLGKRHHADVAILGDAALAIDEILNKVDAVEESAWWTANLKNIA 347 Query: 359 ----------VPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTY-GI 407 L+ ++N + N E + + G S + Sbjct: 348 NWREYINMLETKEEGDLQFYQVYNAINNHADEDAIYSIDVGNSTQTSIRHLHMTPKNMWR 407 Query: 408 SQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLF 467 + L+ ++G LGA + P ++V IGDG+ +T ++ T +R+ + Sbjct: 408 TSPLFATMGIAIPGGLGA----KNTYPDRQVWNIIGDGAFSMTYPDVVTNVRYNMPVINV 463 Query: 468 VLNNDGYTIEKLIHG---PKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQD 524 V +N Y K + + D+ + GAK + R+ + + Sbjct: 464 VFSNTEYAFIKNKYEDTNKNLFGVDFTDVDYAKIAEAQGAKGFTVSRIEDMDR--VMAEA 521 Query: 525 KSFNDNSKIRMIEIMLPVFDAPQ 547 + N +I+ + Sbjct: 522 VAANKAGHTVVIDCKITQDRPIP 544 >1UPC-A nrPDB Length = 573 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 99/534 (18%), Positives = 180/534 (33%), Gaps = 51/534 (9%) Query: 37 IYEVEGMRWAGNANELNAAYAADGYARIKGMS-CIITTFGVGELSALNGIAGSYAEHVGV 95 EVEG+ + +E A AAD ARI G T G G + GIA S + V Sbjct: 43 FDEVEGIDFVLTRHEFTAGVAADVLARITGRPQACWATLGPGMTNLSTGIATSVLDRSPV 102 Query: 96 LHVVGVPSISAQAKQLLLHHTLGNGDFTVFHRMS--ANISETTAMITDIATAPAEIDRCI 153 + + A Q H N ++ A +S+ + +D + Sbjct: 103 IAL---------AAQSESHDIFPNDTHQCLDSVAIVAPMSKYAVELQRPHEITDLVDSAV 153 Query: 154 RTTYVTQ-RPVYLGLPANLV--DLNVPAKLLQTPIDMSLKPND--AESEKEVIDTILALV 208 P ++ LP +L+ + + P + KP A+ ++ D AL+ Sbjct: 154 NAAMTEPVGPSFISLPVDLLGSSEGIDTTVPNPPANTPAKPVGVVADGWQKAADQAAALL 213 Query: 209 KDAKNPVILADACCSRHDVKAETKKLIDLTQFPAFVTPMGKGSIDEQHPRYGGV----YV 264 +AK+PV++ A R + L + P T + KG + H G Sbjct: 214 AEAKHPVLVVGAAAIRSGAVPAIRALAERLNIPVITTYIAKGVLPVGHELNYGAVTGYMD 273 Query: 265 GTLSKPEVKEAVESADLILSVGALLS-DFNTGSFSYSYKTKNIVEFHSDHMKIRNATFPG 323 G L+ P ++ DL+L+VG + D + + K V I P Sbjct: 274 GILNFPALQTMFAPVDLVLTVGYDYAEDLRPSMWQKGIE-KKTVRISPTVNPIPRVYRPD 332 Query: 324 VQMKFVLQKLLTTIADAAKGY--------KPVAVPARTPANAAVPASTPLKQEWMWNQLG 375 V + + + A + +P+ ++ + + + Sbjct: 333 VDVVTDVLAFVEHFETATASFGAKQRHDIEPLRARIAEFLADPETYEDGMRVHQVIDSMN 392 Query: 376 NFLQEGD-----VVIAETGTS-AFGINQTTFPNNTYGISQVLWGSIGFTTGATLGAAFAA 429 ++E ++++ G +G+ ++ S G+ A +GA A Sbjct: 393 TVMEEAAEPGEGTIVSDIGFFRHYGVLFARADQPFGFLTSAGCSSFGYGIPAAIGAQMA- 451 Query: 430 EEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLI-----HGPK 484 P + L GDG ++ T+ R L V+NND + +L H Sbjct: 452 ---RPDQPTFLIAGDGGFHSNSSDLETIARLNLPIVTVVVNNDTNGLIELYQNIGHHRSH 508 Query: 485 AQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSFNDNSKIRMIEI 538 + G D ++L A + R E + + + + +IE+ Sbjct: 509 DPAVKFGGVDFVALAE---ANGVDATRATNREELLAALRKGA--ELGRPFLIEV 557 >3LQ1-A nrPDB Length = 578 Score = 102 bits (253), Expect = 6e-22, Method: Composition-based stats. Identities = 84/561 (14%), Positives = 177/561 (31%), Gaps = 49/561 (8%) Query: 8 KYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARIKGM 67 E L Q V PG + L + E ++ + +E +A + A G A+ Sbjct: 15 AAFIEELVQAGVKEAIISPGSRSTPLALMMAEHPILKIYVDVDERSAGFFALGLAKASKR 74 Query: 68 SCIIT-TFGVGELSALNGIAGSYAEHVGVLHVVG---VPSISAQAKQLLLHHTLGNGDFT 123 ++ T G + +A + + ++ + + A Q + L Sbjct: 75 PVVLLCTSGTAAANYFPAVAEANLSQIPLIVLTADRPHELRNVGAPQAMDQLHLYGSHVK 134 Query: 124 VFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLLQT 183 F M+ + + +D ++T + PV+L P + + T Sbjct: 135 DFTDMALPENSEEMLRYAKWHGSRAVDIAMKT---PRGPVHLNFPLREPLVPILEPSPFT 191 Query: 184 PIDMSLKPNDAESEKEVID--TILALVKD--AKNPVILADACCSRHDVKAETKKLIDLTQ 239 EV+D +I +V + K V + + +++ L Sbjct: 192 ATGKKHHHVHIYYTHEVLDDSSIQKMVTECTGKKGVFVVGP-IDKKELEQPMVDLAKKLG 250 Query: 240 FPAFVTPM-GKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTGSFS 298 +P P+ G S Y L + E+ + + + ++++ G++ ++ Sbjct: 251 WPILADPLSGLRSYGALDEVVIDQYDAFLKEAEIIDKL-TPEVVIRFGSMPVSKPLKNWL 309 Query: 299 YSYKTKNIVEFHS-----DHMKIRNATFPGVQMKFVLQKLLTTIADAAK------GYKPV 347 D +K +F+L + + D AK G+ Sbjct: 310 EQLSDIRFYVVDPGAAWKDPIKAVTDMI-HCDERFLLDIMQQNMPDDAKDAAWLNGWTSY 368 Query: 348 AVPARTPANAAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSA----FGINQTTFPNN 403 AR A + +T L++ + +L L + + G S + Sbjct: 369 NKVAREIVLAEMANTTILEEGKIVAELRRLLPDKAGLF--IGNSMPIRDVDTYFSQIDKK 426 Query: 404 TYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLK 463 ++ I + LGA+ + + L IGD S + + ++ + Sbjct: 427 IKMLANRGANGIDGVVSSALGASVVFQ------PMFLLIGDLSFYHDMNGLLMAKKYKMN 480 Query: 464 PYLFVLNNDGYTIEKLIHGPKAQ------YNEIQGWDHLSLLPTFGAKDYETHRVATTGE 517 + ++NNDG I + + D F DY H + E Sbjct: 481 LTIVIVNNDGGGIFSFLPQANEPKYFESLFGTSTELDFR-FAAAFYDADY--HEAKSVDE 537 Query: 518 WDKLTQDKSFNDNSKIRMIEI 538 ++ S++ + +IE+ Sbjct: 538 LEEAIDKASYHK--GLDIIEV 556 >2X7J-A nrPDB Length = 604 Score = 98.4 bits (243), Expect = 8e-21, Method: Composition-based stats. Identities = 85/578 (14%), Positives = 174/578 (30%), Gaps = 55/578 (9%) Query: 1 MSEITLGKY------LFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNA 54 M E+T+ + + PG + L + +E +A Sbjct: 22 MLEMTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHPDISVHVQIDERSA 81 Query: 55 AYAADGYARIKGMSCIIT-TFGVGELSALNGIAGSYAEHVGVLHVVGV---PSISAQAKQ 110 + A G A+ K ++ T G + + ++ V ++ + A Q Sbjct: 82 GFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVLTADRPHELREVGAPQ 141 Query: 111 LLLHHTLGNGDFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPAN 170 + H L G+F F SA E+ M+ I T + PV++ +P Sbjct: 142 AINQHFL-FGNFVKFFTDSALPEESPQMLRYIRTLASRA--AGEAQKRPMGPVHVNVPLR 198 Query: 171 LVDL----NVPAKLLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHD 226 + + P ++T +S+K ++E + + ++ +A+ +I+ Sbjct: 199 EPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAEAEKGMIVCG-ELHSDA 257 Query: 227 VKAETKKLIDLTQFPAFVTPMGKGSIDEQHPRY--GGVYVGTLSKPEVKEAVESADLILS 284 K L Q+P P+ + H + Y L E+K + D+++ Sbjct: 258 DKENIIALSKALQYPILADPLS-NLRNGVHDKSTVIDAYDSFLKDDELKRKLR-PDVVIR 315 Query: 285 VGALLSDFNTGSFSYSYKTKNIVEFHSDHM----KIRNATFPGVQMKFVLQKLLTTIADA 340 G + + T + D +A ++++ + A Sbjct: 316 FGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIHCNASVFAEEIMAGLTAA 375 Query: 341 AKGYKPVAVPARTPANAAVPASTPLKQE-----WMWNQLGNFLQEGDVVIAETGTSA--- 392 + + + T ++ ++ L + + E + G S Sbjct: 376 TRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQHLVPENSSLFV--GNSMPIR 433 Query: 393 -FGINQTTFPNNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTV 451 S I + +G K V L IGD S + Sbjct: 434 DVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGT-----KAPVTLVIGDLSFYHDL 488 Query: 452 QEISTMIRWGLKPYLFVLNNDGYTIEKL--IHGPKAQYNEI----QGWDHLSLLPTFGAK 505 + + G+ + ++NNDG I K + ++ G D +G Sbjct: 489 NGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGTPTGLDFKHAAALYGG- 547 Query: 506 DYETHRVATTGEWDKLTQDKS-FNDNSKIRMIEIMLPV 542 + WD+ + D + +IEI Sbjct: 548 -----TYSCPASWDEFKTAYAPQADKPGLHLIEIKTDR 580 >2JLA-A nrPDB Length = 558 Score = 93.8 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 78/579 (13%), Positives = 161/579 (27%), Gaps = 73/579 (12%) Query: 7 GKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARIKG 66 + E L + V + PG + L E + +E + A G A++ Sbjct: 13 AAVILEALTRHGVRHICIAPGSRSTPLTLAAAENSAFIHHTHFDERGLGHLALGLAKVSK 72 Query: 67 MSCI-ITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFTVF 125 I T G + + + ++ + A + G Sbjct: 73 QPVAVIVTSGTAVANLYPALIEAGLTGEKLILLT--------ADRPPELIDCGANQAIRQ 124 Query: 126 HRM-SANISETTAMITDIATAPAE-----IDRCIRTTYVTQRPVYLGLP-ANLVDLNVPA 178 M +++ + + ++ PA ID + T V++ P A + + Sbjct: 125 PGMFASHPTHSISLPRPTQDIPARWLVSTIDHALGTL--HAGGVHINCPFAEPLYGEMDD 182 Query: 179 KLLQTPI-------DMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAET 231 L D +A + + K V++A + K Sbjct: 183 TGLSWQQRLGDWWQDDKPWLREAPRLESEKQRDWFFWRQ-KRGVVVAGRMSAEEGKKVAL 241 Query: 232 KKLIDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSD 291 +P + + P L + ++ A +++ +G+ L+ Sbjct: 242 --WAQTLGWPLIGDVLSQ----TGQPLPCADLW--LGNAKATSELQQAQIVVQLGSSLTG 293 Query: 292 FNTGSFSYSYKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPA 351 + S + + ++ A G IA+ A + Sbjct: 294 KRLLQWQASCEPEEYWIVDDIEGRLDPAHHRG----------RRLIANIADWLELHPAEK 343 Query: 352 RTPANAAVPASTPLKQEWMWNQLGNFLQEGDV-----VIAETGTSAFGINQT-------- 398 R P +P + + + F + + E G G + Sbjct: 344 RQPWCVEIPRLAEQAMQAVIARRDAFGEAQLAHRICDYLPEQGQLFVGNSLVVRLIDALS 403 Query: 399 TFPNNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMI 458 P S I G A+ K + +GD S + ++ + Sbjct: 404 QLPAGYPVYSNRGASGIDGLLSTAAGVQRAS-----GKPTLAIVGDLSALYDLNALALLR 458 Query: 459 RWGLKPYLFVLNNDGYTIEKLIHGPKAQ----YNEIQGWDHLSLLPTFGAKDYETHRVAT 514 + L V+NN+G I L+ P+++ Y Q F + Sbjct: 459 QVSAPLVLIVVNNNGGQIFSLLPTPQSERERFYLMPQNVHFEHAAAMFE------LKYHR 512 Query: 515 TGEWDKLTQDKSFNDNSK-IRMIEIMLPVFDAPQNLVEQ 552 W +L + + +IE+++ D Q L + Sbjct: 513 PQNWQELETAFADAWRTPTTTVIEMVVNDTDGAQTLQQL 551 >5ESS-A nrPDB Length = 574 Score = 68.3 bits (165), Expect = 9e-12, Method: Composition-based stats. Identities = 81/509 (15%), Positives = 139/509 (27%), Gaps = 47/509 (9%) Query: 5 TLGKYLFERLKQVNVNTVFGLPGDFNLSL---LDKIYEVEGMRWAGNANELNAAYAADGY 61 T + + + L + V V PG N L L +R +E A Y A G Sbjct: 26 TQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGYLAIGL 85 Query: 62 ARIKGMSCIIT-TFGVGELSALNGIAGSYAEHVGVLHVVGV-PSISAQAKQLLLHHTLGN 119 A G + T G + + + V ++ + P LG Sbjct: 86 AIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQLGY 145 Query: 120 GDFTVFHRMSANISETTAMITDIATAPAEID--RCIRTTYVTQ----RPVYLGLPANLVD 173 V +S ++E T A R + + PV+ +P Sbjct: 146 FGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREPL 205 Query: 174 LNVPAKL-LQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETK 232 + P L TP + D L + + + V+++ H A Sbjct: 206 VPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLD-IDLSVDTVVISGHGAGVHPNLAALP 264 Query: 233 KLIDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDF 292 + + P P V L +P + V +L A + F Sbjct: 265 TVAE----PTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVS----VLLADAEVPVF 316 Query: 293 NTGSFSYSYKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPAR 352 + + A P D A+ A Sbjct: 317 ALTTGPRWPDVSGNSQATGTRAVTTGAPRP-------------AWLDRCAAMNRHAIAAV 363 Query: 353 TPANAAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFG-INQTTFPNNTYGISQVL 411 AA P +T L + + + L+ GD ++ S Sbjct: 364 REQLAAHPLTTGLH---VAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRG 420 Query: 412 WGSIGFTTGATLGAAFA-----AEEIDPKK--RVILFIGDGSLQLTVQEISTMIRWGLK- 463 I T +GAA A P R I IGD + + + Sbjct: 421 VAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPR 480 Query: 464 -PYLFVLNNDGYTIEKLIHGPKAQYNEIQ 491 + V N++G I +L+ +++++ Sbjct: 481 SLTIVVSNDNGGGIFELLEQGDPRFSDVS 509 >3CF4-G nrPDB Length = 170 Score = 44.8 bits (104), Expect = 9e-05, Method: Composition-based stats. Identities = 17/147 (11%), Positives = 50/147 (34%), Gaps = 12/147 (8%) Query: 202 DTILALVKDAKNPVILADACCSRHDVKAETKKLIDLTQFPAFVTPMGKGSIDEQ------ 255 + ++ AK P+++ ++ K+ P T + ++ Sbjct: 25 EMAAKIISKAKRPLLMVGTLALDPELLDRVVKISKAANIPIAATGSSLAVLADKDVDAKY 84 Query: 256 -HPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDFNTG-SFSYSYKTKNIVEFHSDH 313 + G Y+ P + + + D+I+++G N S + ++ + + Sbjct: 85 INAHMLGFYLTDPKWPGL-DGNGNYDMIITIGFKKFYINQVLSAAKNFSNLKTIAIERGY 143 Query: 314 MKIRNATFPGV---QMKFVLQKLLTTI 337 ++ +F + L +L+ + Sbjct: 144 IQNATMSFGNLSKADHYAALDELINAL 170 >5B48-A nrPDB Length = 627 Score = 41.4 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 17/79 (21%), Positives = 30/79 (37%), Gaps = 9/79 (11%) Query: 39 EVEGMRWAGNANELNAAYAADGYARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHV 98 + + +EL A A G A + G+ T G G + G+ + V V+ Sbjct: 282 KKGTIVVVQAEDELAAINMAIGAA-LTGVRAATATSGPGFSLMVEGLGWAGMNEVPVVIT 340 Query: 99 --------VGVPSISAQAK 109 G+P+ +AQ+ Sbjct: 341 YYIRGGPSTGLPTRTAQSD 359 >3I9V-3 nrPDB Length = 783 Score = 39.8 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 27/202 (13%), Positives = 57/202 (28%), Gaps = 34/202 (16%) Query: 198 KEVIDTILALVKDAKNPVILADACCSR-HDVKAETKKLIDLTQFPAFVT--------PMG 248 E++ + AKNPV++ A + + L + Sbjct: 487 SEMVAKAKEAWEKAKNPVLILGAGVLQDTVAAERARLLAERKGAKVLAMTPAANARGLEA 546 Query: 249 KGSIDE------QHPRYGGVYVGTLSKPEVKEAVESADLILS-------VGALLSDFNTG 295 G + P Y G + +EA++ ++ + + Sbjct: 547 MGVLPGAKGASWDEPGALYAYYGFV---PPEEALKGKRFVVMHLSHLHPLAERYAHVVLP 603 Query: 296 SFSYSYKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVAVPARTPA 355 + ++ K ++V + + A + + LQ L A+ R P Sbjct: 604 APTFYEKRGHLVNLEGRVLPLSPAPIENGEAEGALQVL---------ALLAEALGVRPPF 654 Query: 356 NAAVPASTPLKQEWMWNQLGNF 377 + A LK + +G Sbjct: 655 RLHLEAQKALKARKVPEAMGRL 676 >6N2O-B nrPDB Length = 292 Score = 39.1 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 15/118 (12%), Positives = 34/118 (28%), Gaps = 11/118 (9%) Query: 370 MWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGISQVLWGSIGFTTGATLGAAFAA 429 ++ + + A +G + G A Sbjct: 38 VYRAMAELGIDSTKFAAISGIGCSSRMPYFVDSYKMHTLHGRAG----------AVATGT 87 Query: 430 EEIDPKKRVILFIGDG-SLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLIHGPKAQ 486 + P V++ GDG + + M R + +++N Y + K + P ++ Sbjct: 88 QVARPDLCVVVAGGDGDGFSIGGGHMPHMARKNVNMTYVLMDNGIYGLTKGQYSPTSR 145 >5B47-B nrPDB Length = 304 Score = 38.7 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 16/67 (23%), Positives = 28/67 (41%), Gaps = 1/67 (1%) Query: 419 TGATLGAAFAAEEIDPKKRVILFIGDG-SLQLTVQEISTMIRWGLKPYLFVLNNDGYTIE 477 G ++ A + +P VI+ +GDG L + + + R + + V NN Y + Sbjct: 65 HGRSIAFATGIKLSNPSLEVIVNVGDGDGLGIGMGHFVHLGRRNIDIAVLVHNNGVYGLT 124 Query: 478 KLIHGPK 484 K P Sbjct: 125 KGQASPT 131 >5B46-A nrPDB Length = 628 Score = 37.9 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 20/80 (25%), Positives = 29/80 (36%), Gaps = 9/80 (11%) Query: 38 YEVEGMRWAGNANELNAAYAADGYARIKGMSCIITTFGVGELSALNGIAGSYAEHVGVLH 97 G+ +EL A A G A + G+ T G G GI+ + V V+ Sbjct: 281 LRKGGVVVVQAEDELAAINMAVGAA-LTGVRSATATSGPGFSLMSEGISWAGMNEVPVVI 339 Query: 98 V--------VGVPSISAQAK 109 G+P+ S QA Sbjct: 340 TYYMRGAPATGLPTRSGQAD 359 >2O1S-A nrPDB Length = 621 Score = 37.1 bits (84), Expect = 0.022, Method: Composition-based stats. Identities = 18/66 (27%), Positives = 29/66 (43%), Gaps = 3/66 (4%) Query: 413 GSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWG--LKPYLFVLN 470 G + A +G A AAE+ +R + IGDG++ M G L +LN Sbjct: 121 GHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAIT-AGMAFEAMNHAGDIRPDMLVILN 179 Query: 471 NDGYTI 476 ++ +I Sbjct: 180 DNEMSI 185 >1YTL-A nrPDB Length = 174 Score = 36.7 bits (83), Expect = 0.025, Method: Composition-based stats. Identities = 27/163 (16%), Positives = 55/163 (33%), Gaps = 22/163 (13%) Query: 178 AKLLQTPIDMSLKPNDA-ESEKEVIDTILALVKDAKNPVILADACCSRHDVKAETKKLID 236 AK L+ P D++ P + E + ++K AK P+++ + ++ KK ++ Sbjct: 1 AKALEQPFDVANIPGPKMATLLEKGKPVANMIKKAKRPLLIVGPDMTD-EMFERVKKFVE 59 Query: 237 LTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVE-----------SADLILSV 285 T + G V E+ + + + DL+L + Sbjct: 60 K-DITVVATGSAITRFID---AGLGEKVNYAVLHELTQFLLDPDWKGFDGQGNYDLVLML 115 Query: 286 GALLSDFNTGSFSYSYKTKNIVEFHSDHMKIRNATFPGVQMKF 328 G++ ++ + K H + I P M F Sbjct: 116 GSIY--YHGSQMLAAIKN---FAPHIRALAIDRYYHPNADMSF 153 >4KXX-A nrPDB Length = 637 Score = 34.4 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 20/73 (27%), Positives = 31/73 (42%), Gaps = 3/73 (4%) Query: 400 FPNNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKK-RVILFIGDGSLQL-TVQE-IST 456 P + V GS+G GA G A+ + D RV +GDG L +V E ++ Sbjct: 110 HPVPKQAFTDVATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAF 169 Query: 457 MIRWGLKPYLFVL 469 + L + +L Sbjct: 170 ASIYKLDNLVAIL 182 >4DI9-A nrPDB Length = 303 Score = 33.7 bits (75), Expect = 0.24, Method: Composition-based stats. Identities = 33/267 (12%), Positives = 76/267 (28%), Gaps = 24/267 (8%) Query: 150 DRCIRTTYVTQRPVYLGLPANL-VDLNVPAKLLQTPIDMSLKPNDAESEKEVIDTILALV 208 +R + +P Y P + +V + Q P K ++ +++ + + Sbjct: 7 ERILSWNETPSKPRYTPPPGAIDAHCHVFGPMAQFPFSPKAKYLPRDAGPDMLFALRDHL 66 Query: 209 KDAKNPVILA-DACCSRHDVKAET-KKLIDLTQFPAFVTPMGKGSIDEQHPR-YGGVYVG 265 A+N ++ A + + + + H G+ Sbjct: 67 GFARNVIVQASCHGTDNAATLDAIARAQGKARGIAVVDPAIDEAELAALHEGGMRGIRFN 126 Query: 266 TLSKPEVKEAVESA--DLILSVGALLSDFNTGSFSYSYKTKNIVEFHSDHMKIRNATFPG 323 L K V+ A D L V L + ++ F +D ++ Sbjct: 127 FL-----KRLVDDAPKDKFLEVAGRL----PAGW------HVVIYFEADILEELRPFMDA 171 Query: 324 VQMKFVLQKLLT-TIADAAKGYKPVAVPARTPANAAV--PASTPLKQEWMWNQLGNFLQE 380 + + V+ + + G A + + A+ P + + +F + Sbjct: 172 IPVPIVIDHMGRPDVRQGPDGADMKAFRRLLDSREDIWFKATCPDRLDPAGPPWDDFARS 231 Query: 381 GDVVIAETGTSAFGINQTTFPNNTYGI 407 ++A+ PN I Sbjct: 232 VAPLVADYADRVIWGTAWPHPNMQDAI 258 >3T6J-A nrPDB Length = 726 Score = 32.9 bits (73), Expect = 0.43, Method: Composition-based stats. Identities = 11/34 (32%), Positives = 16/34 (47%) Query: 24 GLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYA 57 G+P N+ D + + EG + N L AYA Sbjct: 385 GIPAGINIPNYDDLRQTEGFKNVSLGNVLAVAYA 418 >5JLR-A nrPDB Length = 396 Score = 32.5 bits (72), Expect = 0.52, Method: Composition-based stats. Identities = 12/76 (15%), Positives = 27/76 (35%), Gaps = 7/76 (9%) Query: 217 LADACCSRHDVKAETKKLIDLTQFPAFVT-PMGKGSIDEQHPRYGGVYVGTLSKPEVKEA 275 + R ++ P T +G G+ D G+ + +KP ++E Sbjct: 306 VVGPIIDRAGKATALREFAQRAGVPMAQTVAVGDGANDIDMLAAAGLGIAFNAKPALREV 365 Query: 276 VESA------DLILSV 285 +++ D +L + Sbjct: 366 ADASLSHPYLDTVLFL 381 >5JTL-E nrPDB Length = 471 Score = 32.5 bits (72), Expect = 0.54, Method: Composition-based stats. Identities = 40/257 (15%), Positives = 73/257 (28%), Gaps = 35/257 (13%) Query: 153 IRTTYVTQRPVYLGLPANLVDLNVPAKLLQTPIDMSLKPNDAESEKEVIDTILALVKDAK 212 + + PV A D+ P + D + D+ S+ K AK Sbjct: 18 VTKARTPEMPVLENRAAQ-GDITAPGGARRLTGDQTAALRDSLSD-----------KPAK 65 Query: 213 NPVILADACCSRHDVKAETKKLIDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEV 272 N ++L ++ A + + G G + + Sbjct: 66 NIILLIGDGMGDSEITAA-RNYAEGAG----------GFFKGIDALPL---TGQYTHYAL 111 Query: 273 KEAVESADLILSVGALLSDFNTGSFSYSYKTKNIVEFHSDHMKIRNATFPGVQ------- 325 + D + A + ++TG +Y+ + + A G+ Sbjct: 112 NKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTA 171 Query: 326 -MKFVLQKLLTTIADAAKGYKPVAVPARTPANAAVPASTPLKQEWMWNQLGNF-LQEGDV 383 ++ L + K Y P A + P NA E + N + L G Sbjct: 172 ELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAK 231 Query: 384 VIAETGTSAFGINQTTF 400 AET T+ +T Sbjct: 232 TFAETATAGEWQGKTLR 248 >3DVA-A nrPDB Length = 369 Score = 32.1 bits (71), Expect = 0.60, Method: Composition-based stats. Identities = 17/129 (13%), Positives = 32/129 (24%), Gaps = 12/129 (9%) Query: 415 IGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQ----LTVQEISTMIRWGLKPYLFVLN 470 IG G A + K I + GDG + + V N Sbjct: 145 IGAQYIQAAGVALGLKMRGKKAVAITYTGDGGTSQGDFYEGINFAGA--FKAPAIFVVQN 202 Query: 471 NDGYTIEKLIHGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSFNDN 530 N P + + ++ + K ++++ N Sbjct: 203 NR-----FAASTPVEKQTVAKTLAQKAVAAGIPGIQVDGMDPLAVYAAVKAARERAINGE 257 Query: 531 SKIRMIEIM 539 +IE + Sbjct: 258 GPT-LIETL 265 >6N2O-A nrPDB Length = 573 Score = 32.1 bits (71), Expect = 0.68, Method: Composition-based stats. Identities = 23/114 (20%), Positives = 38/114 (33%), Gaps = 18/114 (15%) Query: 36 KIYEVEGMRWAGNANELNAAYAADGYARIKGMSCIITTFGVGELSALNGIAGSYAEHVGV 95 + + E A A L A+YA G + T G G + ++ Sbjct: 246 DLVQAED-EIASIAQVLGASYA--------GKKSMTATSGPGLALMSEMLGMAHMSETPC 296 Query: 96 LHV--------VGVPSISAQAKQLLLHHTLGNGDFTVFHRMSANISETTAMITD 141 L V G+P+ Q+ L H G+GD ++ + +M D Sbjct: 297 LVVDVQRGGPSTGLPTKHEQSDLFLAIH-GGHGDSPRIVLSVEDVKDCISMTVD 349 >3ILN-A nrPDB Length = 251 Score = 31.7 bits (70), Expect = 0.83, Method: Composition-based stats. Identities = 22/150 (14%), Positives = 35/150 (23%), Gaps = 6/150 (4%) Query: 289 LSDFNTGSFSYSYKTKNIVEFHSDHMKIRNATFPGVQMKFVLQKLLTTIADAAKGYKPVA 348 L D T +Y I D + P V V K + +G Sbjct: 107 LPDRQTYGSAYWPDNGEI-----DIAEHVGF-NPDVVHGTVHTKAYNHLLGTQRGGSIRV 160 Query: 349 VPARTPANAAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNTYGIS 408 ART + TP + W + + + + F Sbjct: 161 PTARTDFHVYAIEWTPEEIRWFVDDSLYYRFPNERLTNPEADWRHWPFDQPFHLIMNIAV 220 Query: 409 QVLWGSIGFTTGATLGAAFAAEEIDPKKRV 438 WG A + + + V Sbjct: 221 GGTWGGQQGVDPEAFPAQLVVDYVRVYRWV 250 >3BC1-A nrPDB Length = 195 Score = 31.4 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 11/51 (21%), Positives = 19/51 (37%), Gaps = 5/51 (9%) Query: 205 LALVKDAKNPVILADA-----CCSRHDVKAETKKLIDLTQFPAFVTPMGKG 250 L + ++NP I+ R + E ++L + P F T G Sbjct: 119 LQMHAYSENPDIVLCGNKSDLEDQRAVKEEEARELAEKYGIPYFETSAANG 169 >1M93-B nrPDB Length = 245 Score = 31.0 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 16/60 (26%), Positives = 26/60 (43%), Gaps = 1/60 (1%) Query: 4 ITLGKYLFERLKQVNVNTVFGLPGDF-NLSLLDKIYEVEGMRWAGNANELNAAYAADGYA 62 +T L + L ++ + VFG GD+ N+S D + + + NE AA A Sbjct: 185 VTGSYNLVDALVKLGLTEVFGSTGDYSNMSNSDVSVDAMIHKTYIDVNEEYTEAAAATSA 244 >1C8O-A nrPDB Length = 300 Score = 31.0 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 16/60 (26%), Positives = 26/60 (43%), Gaps = 1/60 (1%) Query: 4 ITLGKYLFERLKQVNVNTVFGLPGDF-NLSLLDKIYEVEGMRWAGNANELNAAYAADGYA 62 +T L + L ++ + VFG GD+ N+S D + + + NE AA A Sbjct: 240 VTGSYNLVDALVKLGLTEVFGSTGDYSNMSNSDVSVDAMIHKTYIDVNEEYTEAAAATSA 299 >2O1X-A nrPDB Length = 629 Score = 31.0 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 16/62 (25%), Positives = 27/62 (43%), Gaps = 2/62 (3%) Query: 413 GSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSL--QLTVQEISTMIRWGLKPYLFVLN 470 G + LG A A + V IGDGSL + + ++T+ G K + + + Sbjct: 123 GHASTSLTNALGMALARDAQGKDFHVAAVIGDGSLTGGMALAALNTIGDMGRKMLIVLND 182 Query: 471 ND 472 N+ Sbjct: 183 NE 184 >1X7Z-A nrPDB Length = 400 Score = 31.0 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 24/126 (19%), Positives = 41/126 (32%), Gaps = 14/126 (11%) Query: 419 TGATLGAAFAAEEIDPKKRVILFIGDGSLQ---LTVQEISTMIRWGLKPYLFVLNNDGYT 475 +GAA+AA+ + + VI + G+G+ + F NN GY Sbjct: 168 IPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAG-FNFAATLECPIIFFCRNN-GYA 225 Query: 476 IEKLIHGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTG--EWDKLTQDKSFNDNSKI 533 I P ++ G P +G K + ++ +N Sbjct: 226 I----STPTSEQYRGDGIAARG--PGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPF 279 Query: 534 RMIEIM 539 +IE M Sbjct: 280 -LIEAM 284 >1RT8-A nrPDB Length = 513 Score = 31.0 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 20/122 (16%), Positives = 42/122 (34%), Gaps = 16/122 (13%) Query: 444 DGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIEKLIHGPKAQYNEIQGWDHLSLLPTFG 503 DGS LT+ + M+R I K +H + D ++ + Sbjct: 376 DGSRTLTLALVWQMMRMN--------------ITKTLHSLSRGGKTLSDSDMVAWANSMA 421 Query: 504 AKDYETHRVATTGEWDKLTQDKSFNDNSKIR--MIEIMLPVFDAPQNLVEQAKLTAATNA 561 AK + ++ + + T + I+ ++ L + + L Q A + A Sbjct: 422 AKGGKGSQIRSFRDPSISTGVFVLDVLHGIKSEYVDYNLVTDGSTEELAIQNARLAISIA 481 Query: 562 KQ 563 ++ Sbjct: 482 RK 483 >6GCS-A nrPDB Length = 728 Score = 30.2 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 22/103 (21%), Positives = 42/103 (40%), Gaps = 13/103 (12%) Query: 140 TDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLLQTPIDMSLKPNDAESEKE 199 T+ A ++ IR ++ Q L + + L+ + + L A+ EK Sbjct: 415 TNPRREAAVMNARIRKAWLRQE---LEIASVGPTLDATFDVAE------LGNTHADLEKA 465 Query: 200 VIDTILALVKDAKNPVILADACC-SRHDVKA---ETKKLIDLT 238 + ++K+AKNP+I+ + R D A K ++ T Sbjct: 466 LSGEFGEVLKNAKNPLIIVGSGITDREDAGAFFNTIGKFVEST 508 >6C43-A nrPDB Length = 477 Score = 30.2 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 16/124 (12%), Positives = 32/124 (25%), Gaps = 6/124 (4%) Query: 233 KLIDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSDF 292 L++ MG E G V AVE A + + + Sbjct: 298 ALVEKLGNAVSSLKMGA---PEDESTELGPLSSLAHLKRVTAAVEEAKALSHIRVITGGS 354 Query: 293 NTGSFSYSYKTKNIVEFHSDHMKIRNATFPG---VQMKFVLQKLLTTIADAAKGYKPVAV 349 T Y + + + + ++ F + + ++L D+ G Sbjct: 355 QTEGKGYYFAPTLLADAKQEDAIVQREVFGPVVSITVFDDEDQVLRWANDSRYGLASSVW 414 Query: 350 PART 353 Sbjct: 415 TQDV 418 >3DTI-A nrPDB Length = 301 Score = 30.2 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 36/223 (16%), Positives = 64/223 (28%), Gaps = 30/223 (13%) Query: 51 ELNAAYAADGYARIK-----GMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSIS 105 EL A+Y A R G+ I TF + G+Y V+ + Sbjct: 40 ELAASYGAGLPGRDTHSLMHGLDGITLTFMP-----MGQRDGAYDPEHHVILINSQVRPE 94 Query: 106 AQAKQLLLHHTLGNGDFTVFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYL 165 Q + L H + + + +++ + +++ I T L Sbjct: 95 RQ--RFTLAHEISHALLLGDDDLLSDLHDEYEG--------DRLEQVIETLCNVGAAALL 144 Query: 166 GLPANLVDLNVPAKLLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADACCSRH 225 +PA L+D P +L ++ + AL + PVI A SR Sbjct: 145 -MPAELID---DLLTRFGPTGRALAELARRADVSATSALYALAERTAPPVIYAVCALSRQ 200 Query: 226 ------DVKAETKKLIDLTQFPAFVTPMGKGSIDEQHPRYGGV 262 E + + + HP + Sbjct: 201 EDEGEGGGAKELTVRASSASAGVKYSLSAGTPVPDDHPAALAL 243 >1QS0-A nrPDB Length = 407 Score = 29.4 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 19/127 (14%), Positives = 37/127 (29%), Gaps = 7/127 (5%) Query: 413 GSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLT--VQEISTMIRWGLKPYLFVLN 470 G++ +G A A+ K +IGDG+ + ++ + L V+N Sbjct: 181 GNLATQFVQAVGWAMASAIKGDTKIASAWIGDGATAESDFHTALTFAHVYRAPVILNVVN 240 Query: 471 NDGYTIEKLIHGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDKLTQDKSFNDN 530 N + I + G + + + V W + Sbjct: 241 NQ-WAISTFQAIAGGESTTFAGRGVGCGIASLRVDGNDFVAVYAASRWAA----ERARRG 295 Query: 531 SKIRMIE 537 +IE Sbjct: 296 LGPSLIE 302 >5Q0C-A nrPDB Length = 339 Score = 29.0 bits (63), Expect = 5.2, Method: Composition-based stats. Identities = 6/31 (19%), Positives = 17/31 (54%) Query: 2 SEITLGKYLFERLKQVNVNTVFGLPGDFNLS 32 S +T K + +++ + ++G+ G N++ Sbjct: 37 SMLTAIKAISSAVRKAGLAHLYGIAGSVNVT 67 >3CME-F nrPDB Length = 120 Score = 28.3 bits (61), Expect = 9.2, Method: Composition-based stats. Identities = 17/121 (14%), Positives = 36/121 (29%), Gaps = 12/121 (9%) Query: 161 RPVYLGLPANLVDLNVPAKLLQTPIDMSLKPNDAESEKEVIDTILALVKDAKNPVILADA 220 PVY+ +VPA L ++ D + K+ + ++ ++ Sbjct: 1 MPVYVDF-------DVPADLEDDALEALEVARDTGAVKKGTNETTKSIERGSAELVFVAE 53 Query: 221 CCSRHDVKAETKKLIDLTQFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESAD 280 ++ +L D P + G+ VG+ + AD Sbjct: 54 DVQPEEIVMHIPELADEKGVPFIFVEQ-----QDDLGHAAGLEVGSAAAAVTDAGEADAD 108 Query: 281 L 281 + Sbjct: 109 V 109 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.306 0.119 0.277 Lambda K H 0.267 0.0368 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,891,131 Number of Sequences: 36641 Number of extensions: 621529 Number of successful extensions: 2359 Number of sequences better than 10.0: 67 Number of HSP's better than 10.0 without gapping: 67 Number of HSP's successfully gapped in prelim test: 35 Number of HSP's that attempted gapping in prelim test: 2030 Number of HSP's gapped (non-prelim): 123 length of query: 563 length of database: 10,336,785 effective HSP length: 102 effective length of query: 461 effective length of database: 6,599,403 effective search space: 3042324783 effective search space used: 3042324783 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 61 (28.3 bits)