BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P05804 (603 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3K4D-A nrPDB 1264 0.0 5C70-A nrPDB 666 0.0 6CXS-A nrPDB 572 e-163 6BJW-A nrPDB 515 e-146 3HN3-A nrPDB 506 e-143 6ECA-A nrPDB 497 e-141 6ED2-A nrPDB 496 e-141 4JKL-A nrPDB 484 e-137 5Z19-A nrPDB 457 e-129 5Z1B-A nrPDB 426 e-119 6D89-C nrPDB 181 6e-46 6D8K-A nrPDB 179 2e-45 6NCZ-A nrPDB 177 1e-44 6D8G-A nrPDB 176 2e-44 6ED1-A nrPDB 155 6e-38 6NCW-A nrPDB 154 8e-38 3CMG-A nrPDB 151 9e-37 6MVG-A nrPDB 148 7e-36 6MVF-A nrPDB 134 1e-31 6DXU-D nrPDB 133 3e-31 6MVH-A nrPDB 132 3e-31 3FN9-A nrPDB 132 4e-31 5T99-A nrPDB 131 1e-30 6D1P-A nrPDB 128 9e-30 5EUV-A nrPDB 123 2e-28 6B6L-A nrPDB 122 5e-28 3DEC-A nrPDB 119 3e-27 3GM8-A nrPDB 108 6e-24 6ETZ-A nrPDB 102 4e-22 4YPJ-A nrPDB 101 8e-22 5DMY-A nrPDB 99 7e-21 5T9G-A nrPDB 79 5e-15 4CUC-A nrPDB 78 1e-14 5N6U-A nrPDB 37 0.017 5BX9-A nrPDB 37 0.018 3PZU-A nrPDB 36 0.053 3WFL-A nrPDB 35 0.14 5WH8-A nrPDB 34 0.15 3ZIZ-A nrPDB 34 0.20 1UUQ-A nrPDB 33 0.36 1HRI-3 nrPDB 33 0.45 2X5I-C nrPDB 32 0.90 3WH9-A nrPDB 31 1.6 5A94-A nrPDB 30 4.1 3RTJ-B nrPDB 30 4.3 1VFF-A nrPDB 29 6.2 4XZW-A nrPDB 29 7.3 3TTS-A nrPDB 29 7.5 3WDP-P nrPDB 28 8.2 1BEV-3 nrPDB 28 9.5 >3K4D-A nrPDB Length = 605 Score = 1264 bits (3271), Expect = 0.0, Method: Compositional matrix adjust. Identities = 603/603 (100%), Positives = 603/603 (100%) Query: 1 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI 60 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI Sbjct: 3 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI 62 Query: 61 RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP 120 RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP Sbjct: 63 RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP 122 Query: 121 YVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTP 180 YVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTP Sbjct: 123 YVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTP 182 Query: 181 NTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVVNPH 240 NTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVVNPH Sbjct: 183 NTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVVNPH 242 Query: 241 LWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHEDAD 300 LWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHEDAD Sbjct: 243 LWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHEDAD 302 Query: 301 LRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLS 360 LRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLS Sbjct: 303 LRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLS 362 Query: 361 LGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQG 420 LGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQG Sbjct: 363 LGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQG 422 Query: 421 AREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLET 480 AREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLET Sbjct: 423 AREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLET 482 Query: 481 AEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRV 540 AEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRV Sbjct: 483 AEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRV 542 Query: 541 SAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMNFGEKPQQG 600 SAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMNFGEKPQQG Sbjct: 543 SAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMNFGEKPQQG 602 Query: 601 GKQ 603 GKQ Sbjct: 603 GKQ 605 >5C70-A nrPDB Length = 612 Score = 666 bits (1719), Expect = 0.0, Method: Compositional matrix adjust. Identities = 333/608 (54%), Positives = 432/608 (71%), Gaps = 13/608 (2%) Query: 1 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI 60 ML+P +T TR++ LDGLW F+L ++ + + W S L+ S VP S+ND FAD+ I Sbjct: 9 MLKPQQTTTRDLISLDGLWKFALASDDN--NTQPWTSQLKTSLECPVPASYNDIFADSKI 66 Query: 61 RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP 120 ++ G V+YQR+V +PKGW+ +R ++R +A TH+G+++VN V +H GGYTPFEAD+T Sbjct: 67 HDHVGWVYYQRDVIVPKGWSEERYLVRCEAATHHGRIYVNGNLVADHVGGYTPFEADITD 126 Query: 121 YVIAGKSVRITVCVNNELNWQTIPPGMV-ITDENGKKKQSYFHDFFNYAGIHRSVMLYTT 179 V AG+ R+T+ V+NEL +QTIPPG V I + GKK Q+Y HDF+NYAG+ RSV LY+ Sbjct: 127 LVAAGEQFRLTIAVDNELTYQTIPPGKVEILEATGKKVQTYQHDFYNYAGLARSVWLYSV 186 Query: 180 PNTWVDDITVVTHVAQDCNHASVDWQVVAN---GDVSVELRDADQQVVATGQGTSGTLQV 236 P + DITV T V +D+ VVA+ G + V + D D VAT G++GT+ + Sbjct: 187 PQQHIQDITVRTDV--QGTTGLIDYNVVASTTQGTIQVAVIDEDGTTVATSSGSNGTIHI 244 Query: 237 VNPHLWQPGEGYLYEL--CVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFG 294 + HLWQPG YLY+L + S+ D Y L GIR+V V+G QFLIN KPFYFTGFG Sbjct: 245 PSVHLWQPGAAYLYQLHASIIDSSKKTIDTYKLATGIRTVKVQGTQFLINDKPFYFTGFG 304 Query: 295 RHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAA 354 +HED ++RGKG D+ MVHD L+ W+GANS+RTSHYPYAEE++++AD GIVVIDET A Sbjct: 305 KHEDTNIRGKGHDDAYMVHDFQLLHWMGANSFRTSHYPYAEEVMEYADRQGIVVIDETPA 364 Query: 355 VGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEP 414 VG S+G G + N P +S + +N +T++AH QAI+ELI RDKNHPSVVMWSIANEP Sbjct: 365 VGLAFSIGAGAQTSNPPA-TFSPDRINNKTREAHAQAIRELIHRDKNHPSVVMWSIANEP 423 Query: 415 DTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQ 474 + GAREYFAPL + R+LDPTRP+T NV D I+DLFDVLCLNRY+GWY Q Sbjct: 424 ASNEDGAREYFAPLPKLARQLDPTRPVTFANVGLATYKADRIADLFDVLCLNRYFGWYTQ 483 Query: 475 SGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYH 534 + +L+ AE LE+EL W EK +PI++TEYG DT+AGLHS+ WSEE+Q LDMYH Sbjct: 484 TAELDEAEAALEEELRGWTEKYDKPIVMTEYGADTVAGLHSVMVTPWSEEFQVEMLDMYH 543 Query: 535 RVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMNFG 594 RVFDR A+ GEQVWNFADF T+ G+ RV GNKKG+FTRDRKPK+AA LL+KRWT ++ G Sbjct: 544 RVFDRFEAMAGEQVWNFADFQTAVGVSRVDGNKKGVFTRDRKPKAAAHLLRKRWTNLHNG 603 Query: 595 EKPQQGGK 602 +GGK Sbjct: 604 TA--EGGK 609 >6CXS-A nrPDB Length = 602 Score = 572 bits (1473), Expect = e-163, Method: Compositional matrix adjust. Identities = 289/604 (47%), Positives = 405/604 (67%), Gaps = 14/604 (2%) Query: 1 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI 60 ML P+ T +R++ L G+W F L+ N G+ + ++ L+++ +AVP S+ND ++ Sbjct: 4 MLYPIITESRQLIDLSGIWKFKLNEGN-GLTEELSKAPLEDTIEMAVPSSYNDLVESQEV 62 Query: 61 RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP 120 R++ G VWY+R IPK +RIVLRF + TH KV++N + ++EH+GG+TPFEA++ Sbjct: 63 RDHVGWVWYERNFTIPKTLLNERIVLRFGSATHEAKVYLNGELLVEHKGGFTPFEAEIND 122 Query: 121 YVIAGKSVRITVCVNNELNWQTIPPGMVITDE-NGKK--KQSYFHDFFNYAGIHRSVMLY 177 +++G + R+TV VNN ++ T+P G+V E +GKK K S DFFNYAGIHR V +Y Sbjct: 123 LLVSGDN-RLTVAVNNIIDETTLPVGLVKEVEVDGKKVIKNSVNFDFFNYAGIHRPVKIY 181 Query: 178 TTPNTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVV 237 TTP ++++DIT+VT ++ + + + Q V ++ V + D + +VA G+G G L + Sbjct: 182 TTPKSYIEDITIVTDFKENNGYVNYEVQAVGKCNIKVTIIDEENNIVAEGEGKEGKLTIN 241 Query: 238 NPHLWQPGEGYLYELCVTAKSQTEC-DIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRH 296 N HLW+P YLY+L V E D Y G+R+V VK +FLIN+KPFYF GFG+H Sbjct: 242 NVHLWEPMNAYLYKLKVELLDDEEIIDTYFEEFGVRTVEVKDGKFLINNKPFYFKGFGKH 301 Query: 297 EDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVG 356 ED+ + G+G + + + D LM WIGANS+RTSHYPY+EE++ AD GIVVIDET AVG Sbjct: 302 EDSYVNGRGINEAINIKDFNLMKWIGANSFRTSHYPYSEEIMRLADREGIVVIDETPAVG 361 Query: 357 FNLS-LGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPD 415 +L+ + GF G+ PK +E T++AH + ++EL++RDKNHP VVMWS+ANEPD Sbjct: 362 LHLNFMATGF-GGDAPKRDTWKEI---GTKEAHERILRELVSRDKNHPCVVMWSVANEPD 417 Query: 416 TRPQGAREYFAPLAEATRKLDP-TRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQ 474 + +GA+EYF PL + T++LDP RP+T V + + D+ DVLCLNRYYGWYV Sbjct: 418 SDSEGAKEYFEPLIKLTKELDPQKRPVTVVTYLMSTPDRCKVGDIVDVLCLNRYYGWYVA 477 Query: 475 SGDLETAEKVLEKELLAWQEKLHQ-PIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMY 533 GDLE A+++LE EL W+E+ + PI+ TEYG DT+AGLH M++EEYQ + Sbjct: 478 GGDLEEAKRMLEDELKGWEERCPKTPIMFTEYGADTVAGLHDTVPVMFTEEYQVEYYKAN 537 Query: 534 HRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGM-N 592 H V D+ VGEQVWNFADFATSQGI+RV GNKKGIFTR+RKPK A L++RWT + Sbjct: 538 HEVMDKCKNFVGEQVWNFADFATSQGIIRVQGNKKGIFTRERKPKMIAHSLRERWTNIPE 597 Query: 593 FGEK 596 FG K Sbjct: 598 FGYK 601 >6BJW-A nrPDB Length = 635 Score = 515 bits (1327), Expect = e-146, Method: Compositional matrix adjust. Identities = 276/619 (44%), Positives = 382/619 (61%), Gaps = 29/619 (4%) Query: 1 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI 60 ML PV T +R + L G+W F LD G +++W+E L+++ + VP S+ND D Sbjct: 25 MLYPVLTQSRLLSDLSGVWDFKLDNGK-GFEEKWYEKPLKDADTMPVPASYNDLKEGTDF 83 Query: 61 RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP 120 R++ G V+YQR + +P+ QRIVLR AVTHY +++N + + EH+GG+ PFE ++ Sbjct: 84 RDHYGWVFYQRNISVPEYVKSQRIVLRCAAVTHYAMIYLNGKLICEHKGGFLPFEVELND 143 Query: 121 YVIAGKSVRITVCVNNELNWQTIPPG-----------MVITDENGKKKQSYFHDFFNYAG 169 + G ++ +T+ VNN +++ T+P G + + K + + DFFNY G Sbjct: 144 DLQDGDNL-LTIAVNNVIDYTTLPVGGKANMMSGMMGGMGAGASDKPQNNPNFDFFNYCG 202 Query: 170 IHRSVMLYTTPNTWVDDITVVTHV--AQDCNHASVDWQVVANGD------VSVELRDADQ 221 I R V +YTTP T+++DITV + ++ A +++ V G VEL D + Sbjct: 203 ITRPVKIYTTPETYINDITVTADIDFTKEEPSAVLNYNVEIKGKDYNNITCKVELFDEEG 262 Query: 222 QVVATGQGTSGTLQVVNPHLWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQF 281 ++ +G+ GT ++ N LWQP YLY++ VTA D+Y L G+RSV V G +F Sbjct: 263 TKLSETEGSEGTFEISNVRLWQPLNAYLYKIKVTAGQ----DVYTLPYGVRSVRVDGTKF 318 Query: 282 LINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWA 341 LIN KPFYF G+G+HED G+G + + D ++M W ANS+RTSHYPY+EEM+ Sbjct: 319 LINEKPFYFKGYGKHEDTFPNGRGINLPMNTKDISIMKWQHANSFRTSHYPYSEEMMRLC 378 Query: 342 DEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKN 401 DE GIVVIDET AVG NL G G G + + +E +TQ+ H I++LI+RDKN Sbjct: 379 DEEGIVVIDETTAVGVNLQFGGGANFGGERIGTFDKEH-GVQTQEHHKDVIRDLISRDKN 437 Query: 402 HPSVVMWSIANEPDTRPQGAREYFAPLAEATRKLDP-TRPITCVNVMFCDAHTDTISDLF 460 H VVMWSIANEPD+ +GA +YF PL + R+LDP RP T V+V A TD S L Sbjct: 438 HACVVMWSIANEPDSAAEGAYDYFKPLYDLARELDPQKRPCTLVSVQGTTADTDCSSQLS 497 Query: 461 DVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDM 520 DV+CLNRYYGWY DLE +E L KEL W KL +P++ TEYG DT++GLH + M Sbjct: 498 DVICLNRYYGWYFGGPDLEVSEIGLRKELSDWG-KLGKPVMFTEYGADTVSGLHDTTSVM 556 Query: 521 WSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSA 580 ++EEYQ + +M ++VFD VVGEQ WNFADFATSQ +LRV GNKKG+FTRDRKPK Sbjct: 557 YTEEYQVEYYEMNNKVFDEFDFVVGEQAWNFADFATSQSLLRVQGNKKGLFTRDRKPKMV 616 Query: 581 AFLLQKRWTGM-NFGEKPQ 598 A + RW+ + FG K + Sbjct: 617 AHYFRNRWSTIPEFGYKTK 635 >3HN3-A nrPDB Length = 613 Score = 506 bits (1303), Expect = e-143, Method: Compositional matrix adjust. Identities = 282/621 (45%), Positives = 371/621 (59%), Gaps = 54/621 (8%) Query: 1 MLRPVETPTREIKKLDGLWAFSLD---RENCGIDQRWWESALQESRA---IAVPGSFNDQ 54 ML P E+P+RE K+LDGLW+F D G +++W+ L ES + VP SFND Sbjct: 7 MLYPQESPSRECKELDGLWSFRADFSDNRRRGFEEQWYRRPLWESGPTVDMPVPSSFNDI 66 Query: 55 FADADIRNYAGNVWYQREVFIPKGWAGQ---RIVLRFDAVTHYGKVWVNNQEVMEHQGGY 111 D +R++ G VWY+REV +P+ W R+VLR + Y VWVN + +EH+GGY Sbjct: 67 SQDWRLRHFVGWVWYEREVILPERWTQDLRTRVVLRIGSAHSYAIVWVNGVDTLEHEGGY 126 Query: 112 TPFEADVTPYVIAG---KSVRITVCVNNELNWQTIPPGMV--ITDENGKKK----QSYFH 162 PFEAD++ V G +RIT+ +NN L T+PPG + +TD + K Q+ + Sbjct: 127 LPFEADISNLVQVGPLPSRLRITIAINNTLTPTTLPPGTIQYLTDTSKYPKGYFVQNTYF 186 Query: 163 DFFNYAGIHRSVMLYTTPNTWVDDITVVTHVAQDCNHASVDWQVVANGD----VSVELRD 218 DFFNYAG+ RSV+LYTTP T++DDITV T V QD V++Q+ G + V L D Sbjct: 187 DFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQDS--GLVNYQISVKGSNLFKLEVRLLD 244 Query: 219 ADQQVVATGQGTSGTLQVVNPHLWQP-----GEGYLYELCVTAKSQTE----CDIYPLRV 269 A+ +VVA G GT G L+V LW P YLY L V +QT D Y L V Sbjct: 245 AENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYLYSLEVQLTAQTSLGPVSDFYTLPV 304 Query: 270 GIRSVAVKGEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTS 329 GIR+VAV QFLIN KPFYF G +HEDAD+RGKGFD L+V D L+ W+GAN++RTS Sbjct: 305 GIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTS 364 Query: 330 HYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHL 389 HYPYAEE++ D +GIVVIDE VG L + N + H+ Sbjct: 365 HYPYAEEVMQMCDRYGIVVIDECPGVGLALP-----------------QFFNNVSLHHHM 407 Query: 390 QAIKELIARDKNHPSVVMWSIANEPDTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFC 449 Q ++E++ RDKNHP+VVMWS+ANEP + + A Y + T+ LDP+RP+T V+ Sbjct: 408 QVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVTFVSN--S 465 Query: 450 DAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDT 509 + D + DV+CLN YY WY G LE + L + W +K +PII +EYG +T Sbjct: 466 NYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAET 525 Query: 510 LAGLHSMYTDMWSEEYQCAWLDMYHRVFD--RVSAVVGEQVWNFADFATSQGILRVGGNK 567 +AG H M++EEYQ + L+ YH D R VVGE +WNFADF T Q RV GNK Sbjct: 526 IAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNK 585 Query: 568 KGIFTRDRKPKSAAFLLQKRW 588 KGIFTR R+PKSAAFLL++R+ Sbjct: 586 KGIFTRQRQPKSAAFLLRERY 606 >6ECA-A nrPDB Length = 627 Score = 497 bits (1279), Expect = e-141, Method: Compositional matrix adjust. Identities = 267/605 (44%), Positives = 350/605 (57%), Gaps = 27/605 (4%) Query: 1 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI 60 +L PV R +KLDGLW F D G ++ WE+ + ++ VP SFND F D Sbjct: 29 LLYPVTNDQRTDQKLDGLWQFKFDEAGEG-EKSGWETGFHDGVSMPVPASFNDFFTDKAS 87 Query: 61 RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP 120 R Y G+ WY R F+P G+ + LRFDAVTH ++VN +E+ H+GG+ PF AD++ Sbjct: 88 REYTGDFWYSRNFFVPSAAKGKALFLRFDAVTHRATIFVNGKEIRTHEGGFLPFAADISE 147 Query: 121 YVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTP 180 V G + V NNEL+ + +P G IT NGKK F DF+NY+G++RSV L + P Sbjct: 148 AVKYGAENTVVVKGNNELSREALPAGDTITLRNGKKMVRPFFDFYNYSGLNRSVHLLSLP 207 Query: 181 NTWVDDITVVTHVAQDCNHASVDWQVVANGD--VSVELRDADQQVVATGQGTSGTLQVVN 238 V D T +A N A+V++ V NGD V+V L DAD QVVAT QG G LQV N Sbjct: 208 QERVLDYTTTFALA--GNDATVNYTVETNGDAPVTVSLADADGQVVATAQGKQGALQVQN 265 Query: 239 PHLWQPGEGYLYELCVTA--KSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRH 296 HLWQ YLY L + +QT D Y R+GIR++ + G L+N KP Y GFGRH Sbjct: 266 AHLWQVRNAYLYTLTIQLGDDTQTPLDTYTDRIGIRTIKISGTDILVNDKPIYLKGFGRH 325 Query: 297 EDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVG 356 ED+ G+ FD + D ALM WIGANS+RTSHYPY E++ ADE G ++ DE AVG Sbjct: 326 EDSPFAGRAFDLNVEKKDFALMKWIGANSFRTSHYPYDEQVYKIADEEGFLLTDEVPAVG 385 Query: 357 FNLS-------LGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWS 409 F ++ L F G K+L+ + H+ I++LI RDKNHPSV+ WS Sbjct: 386 FKMAAAAFLGGLNQSFFKGPWLKKLH----------ERHIDQIRDLIKRDKNHPSVLAWS 435 Query: 410 IANEPDTRPQGAREYFAPLAEATRKLDPT-RPITCVNVMFCDAHTDTISDLFDVLCLNRY 468 + NEPDT + A YF + + ++ LDP RP T T + D D LNRY Sbjct: 436 LFNEPDTIDENAVPYFKQIFDESKDLDPQGRPRTFTLSEDDTIETSKVLDFPDFYMLNRY 495 Query: 469 YGWYVQSG-DLETAEKVLEKELLAWQEK-LHQPIIITEYGVDTLAGLHSMYTDMWSEEYQ 526 GWY G + E L E+ WQ+ + +P++ TE+G DT AGLH + + MW+EEYQ Sbjct: 496 PGWYHFGGYQISDGEAGLRDEMDKWQKAGVKKPVVFTEFGADTEAGLHKLPSVMWTEEYQ 555 Query: 527 CAWLDMYHRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQK 586 L M+ RVFD + GEQVWN ADF T +G +RV GNKKGIFTRDR+PK+AAF Sbjct: 556 VEVLKMFSRVFDDYDFIKGEQVWNLADFQTVEGNMRVNGNKKGIFTRDRQPKAAAFFYHD 615 Query: 587 RWTGM 591 RW + Sbjct: 616 RWNKL 620 >6ED2-A nrPDB Length = 631 Score = 496 bits (1278), Expect = e-141, Method: Compositional matrix adjust. Identities = 268/599 (44%), Positives = 351/599 (58%), Gaps = 12/599 (2%) Query: 1 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI 60 +L P T TR + LDG+W FS D E+ G++ W L S ++ VP SF D F D Sbjct: 28 LLYPRATTTRRLIGLDGMWRFSFDPESKGVEAGW-ALDLPSSLSMPVPASFCDLFTDKAS 86 Query: 61 RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP 120 R Y G+ WY+ F+P W+G IVLRF +VTH +V+VN EV +H+GG+ PF+A VT Sbjct: 87 REYCGDFWYETSFFVPAEWSGWDIVLRFGSVTHRARVFVNGVEVAQHEGGFLPFDATVTN 146 Query: 121 YVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTP 180 V + +++V NNEL+ +P G T +G+K + + DF+NYAGIHR V L P Sbjct: 147 IVRYNQFNKLSVLANNELSETMLPAGTTCTLADGRKIAAPYFDFYNYAGIHRPVWLMALP 206 Query: 181 NTWVDDITVVTHVAQDCNHASVDWQVVANG--DVSVELRDADQQVVATGQGTSGTLQVVN 238 V D + + + A +D+ V NG V+VEL D + VA GT+GTL V N Sbjct: 207 KERVLDYSTRYRLTE--TGAEIDYTVSTNGPHPVTVELYDGTTR-VAESSGTTGTLVVKN 263 Query: 239 PHLWQPGEGYLYELCVTA-KSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHE 297 LW YLY+L + + D Y R+GIR+ ++ +FL+N P Y GFGRHE Sbjct: 264 ARLWNVHAAYLYDLVIRIHEGSAVVDEYLDRIGIRTFEIRHGRFLLNGSPVYLRGFGRHE 323 Query: 298 DADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGF 357 DAD+RG+G D + D LM WIGAN +RTSHYPYAEE+ ADE G ++IDE AVGF Sbjct: 324 DADIRGRGLDLPTVKRDFELMKWIGANCFRTSHYPYAEEIYQMADEEGFLIIDEVPAVGF 383 Query: 358 NLSLG--IGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPD 415 S + GN ++ + E+ + H A+ ++I RDKNHPSV+ WS+ NEP Sbjct: 384 MQSTANFLAANQGNGRQQGFFEKETTPALLKNHKAALTDMIDRDKNHPSVIAWSLLNEPQ 443 Query: 416 TRPQGAREYFAPLAEATRKLDP-TRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQ 474 G EYF PL E R+LDP RP T +M T D + LNRYYGWYV Sbjct: 444 CTSAGTEEYFKPLFELARRLDPQKRPRTYTVLMTSLPDTSKGQRFADFVSLNRYYGWYVL 503 Query: 475 SG-DLETAEKVLEKELLAWQEKLH-QPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDM 532 G L AE E+ W + LH +P+I TEYG D L+G H + + MWS EYQ +L+M Sbjct: 504 GGAGLADAEAAFHHEMDGWAKVLHGRPLIFTEYGTDNLSGAHKLPSVMWSAEYQNEYLEM 563 Query: 533 YHRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGM 591 H VFD V GE VWNFADF T++GILRV GNKKGIFTR R+PK AA+L +KRWT + Sbjct: 564 THAVFDHYDFVQGELVWNFADFQTTEGILRVDGNKKGIFTRQRQPKDAAYLFRKRWTTL 622 >4JKL-A nrPDB Length = 602 Score = 484 bits (1246), Expect = e-137, Method: Compositional matrix adjust. Identities = 260/610 (42%), Positives = 360/610 (59%), Gaps = 47/610 (7%) Query: 1 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI 60 ML P+ T TR L G+W F L N L + +P SFND + Sbjct: 4 MLYPLLTKTRNTYDLGGIWNFKLGEHNPN-------ELLPSDEVMVIPTSFNDLMVSKEK 56 Query: 61 RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP 120 R+Y G+ WY++ + +PK + +VLRF +VTH K++V+ V EH+GG+TPFE V Sbjct: 57 RDYIGDFWYEKVIEVPKVSEDEEMVLRFGSVTHQAKIYVDGVLVGEHKGGFTPFEVLVPE 116 Query: 121 YVIAGKSVRITVCVNNELNWQTIPPG----MVITDENGKKKQSYFHDFFNYAGIHRSVML 176 + +++++C NN L++ T+P G ++ D + KKK DFFNYAG+HR + L Sbjct: 117 CKYNNEKIKVSICANNVLDYTTLPVGNYSEIIQEDGSIKKKVRENFDFFNYAGVHRPLKL 176 Query: 177 YTTPNTWVDDITVVTHVAQDCNHASVDWQVVAN---GDVSVELRDADQQVVATGQGTSGT 233 P + DIT+ + ++ D A + + V N +V + + D D ++V G+ Sbjct: 177 MIRPKNHIFDITITSRLSDDLQSADLHFLVETNQKVDEVRISVFDEDNKLV--GETKDSR 234 Query: 234 LQVVNPHLWQPGEGYLY----ELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFY 289 L + + HLW+ YLY E+ V + Q D+Y G+R + V QFL+N KP Y Sbjct: 235 LFLSDVHLWEVLNAYLYTARVEIFVDNQLQ---DVYEENFGLREIEVTNGQFLLNRKPIY 291 Query: 290 FTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVI 349 F GFG+HED + G+G + + D L+ +GANS+RTSHYPY+EEM+ AD G++VI Sbjct: 292 FKGFGKHEDTFINGRGLNEAANLMDLNLLKDMGANSFRTSHYPYSEEMMRLADRMGVLVI 351 Query: 350 DETAAVG----FNLSLGIGFEAGNKPKELYSEEAVNG-----ETQQAHLQAIKELIARDK 400 DE AVG FN SL + PK+ NG +T+ AH QAI+EL+ RDK Sbjct: 352 DEVPAVGLFQNFNASLDLS------PKD-------NGTWNLMQTKAAHEQAIQELVKRDK 398 Query: 401 NHPSVVMWSIANEPDTRPQGAREYFAPLAEATRKLDP-TRPITCVNVMFCDAHTDTISDL 459 NHPSVVMW +ANEP + GA +YF PL + + LDP RP+T VN++ D + DL Sbjct: 399 NHPSVVMWVVANEPASHEAGAHDYFEPLVKLYKDLDPQKRPVTLVNILMATPDRDQVMDL 458 Query: 460 FDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKL-HQPIIITEYGVDTLAGLHSMYT 518 DV+CLNRYYGWYV GDL AE + KELL WQ+K +PIIITEYG DTL GLHS + Sbjct: 459 VDVVCLNRYYGWYVDHGDLTNAEVGIRKELLEWQDKFPDKPIIITEYGADTLPGLHSTWN 518 Query: 519 DMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPK 578 ++EE+QC + +M HRVFD + +VGEQVWNFADF T+ ILRV GN KG+F+R+R+PK Sbjct: 519 IPYTEEFQCDFYEMSHRVFDGIPNLVGEQVWNFADFETNLMILRVQGNHKGLFSRNRQPK 578 Query: 579 SAAFLLQKRW 588 +KRW Sbjct: 579 QVVKEFKKRW 588 >5Z19-A nrPDB Length = 627 Score = 457 bits (1177), Expect = e-129, Method: Compositional matrix adjust. Identities = 240/597 (40%), Positives = 343/597 (57%), Gaps = 9/597 (1%) Query: 2 LRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADIR 61 L P++ R ++ LDG+W F D E G + WE+ L ++ VP SF D F D R Sbjct: 31 LYPIQNEYRMMQSLDGMWKFQFDPEEIG-KKSGWENGLPAPVSMPVPSSFADFFTDHKER 89 Query: 62 NYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPY 121 +Y G+ WY+ E ++P W ++I LRF ++TH G V+ N E+ H+GG+ P AD++ Sbjct: 90 DYCGDFWYETEFYLPAEWRNKKIWLRFGSITHRGTVYCNGMEITSHEGGFLPVLADISTV 149 Query: 122 VIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPN 181 G+ ++ V +NNELN ++P G NG+K + DFFNY+G+ RSV + P Sbjct: 150 AKPGQVNQVVVKINNELNETSLPCGATKILNNGRKLAKPYFDFFNYSGLQRSVWVIALPE 209 Query: 182 TWVDDITVVTHVAQDCNHASVDWQVVANGD--VSVELRDADQQVVATGQGTSGTLQVVNP 239 V D +V + A V ++VV G+ V V L DA+ ++VA +G G LQV N Sbjct: 210 ESVKDYSVDYELCG--TDALVKYEVVTTGEHPVIVRLLDAEGELVAETEGKEGILQVANA 267 Query: 240 HLWQPGEGYLYELCV-TAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHED 298 LW+ YLY++ + D Y ++GIR+V ++G + L+N +P Y GFG+HED Sbjct: 268 RLWEVRNAYLYQIVILITDGNGVLDEYREKIGIRTVRIEGTKILLNDRPVYLKGFGKHED 327 Query: 299 ADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFN 358 + G+GF ++ D + W AN +RTSHYPYAEE +ADE G ++IDE AVG Sbjct: 328 FPILGRGFHWGIVKRDFECLKWTNANCFRTSHYPYAEEWYQFADEEGFLIIDEVPAVGMM 387 Query: 359 LSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRP 418 S AG+ + E E ++H+ +E+I RDKNHPSV+ WS+ NEP+T Sbjct: 388 RSTRNFVAAGSGNYTYFFEALTVPELLKSHIADTEEMITRDKNHPSVIAWSLFNEPETIT 447 Query: 419 QGAREYFAPLAEATRKLD-PTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSG- 476 A EYF + A D +RP+T L D +CLNRYYGWY+ G Sbjct: 448 DYAYEYFKEVFAAAETYDFQSRPMTGAFEKNSKPELCKCYPLCDFICLNRYYGWYISGGP 507 Query: 477 DLETAEKVLEKELLAWQEK-LHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHR 535 ++E AE++ E+ W+ K L+ P + TE+G DT+AGLH + + MWSEEYQ +L+M R Sbjct: 508 EIEEAEELFRDEMDRWKAKELNVPFVFTEFGTDTMAGLHKLPSIMWSEEYQKEYLEMNFR 567 Query: 536 VFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMN 592 VFD V GE WNFADF T++GI+RV GN KG+FTRDR+PK+AA + + RW N Sbjct: 568 VFDSYEFVQGELAWNFADFQTTEGIMRVDGNHKGVFTRDRQPKAAAVVFKDRWEKKN 624 >5Z1B-A nrPDB Length = 692 Score = 426 bits (1095), Expect = e-119, Method: Compositional matrix adjust. Identities = 266/688 (38%), Positives = 366/688 (53%), Gaps = 113/688 (16%) Query: 1 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI 60 ML P +R + LDG+W F E+ W ++ L E +AVPGS+NDQ + ++ Sbjct: 25 MLYPQSNDSRIVFPLDGVWDFRTAGEDS-YPAEWADAPLPEPLPMAVPGSYNDQNDELNL 83 Query: 61 RNYAGNVWYQREVFIPKGW-AGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVT 119 R + G V YQR +P AGQR++LRFDA TH V++N Q + H GG+ PFE DVT Sbjct: 84 RAHYGWVVYQRSFAVPSRLVAGQRMILRFDAATHAADVYLNGQLLGSHFGGFLPFEFDVT 143 Query: 120 PYVIAGKSVRITVCVNNELNWQTIP-----------------PGMVITDENGKKKQSYFH 162 + AG+++ +TV V+N + T+P P + ++ +++ Sbjct: 144 SALHAGENL-LTVAVDNRIGSSTLPVGNDAGTAFMGSDNANVPAVAEAKKHARRQNLPNF 202 Query: 163 DFFNYAGIHRSVMLYTTP-NTWVDDITVVT----HVAQD-CNHAS--VDWQVVANGD--- 211 DFFN+AG++R V LYTTP + ++ DI + T H+A D C A+ + + V GD Sbjct: 203 DFFNFAGLNRHVELYTTPADAYIADIAITTERLDHIAGDACTAANALIAYDVTFGGDFPS 262 Query: 212 --------------------------------------VSVELRDADQQVVA-------- 225 V + + D + VVA Sbjct: 263 NPTDPNTLIQPSDPAINHADPSESSESDIQRTATYGRQVRISILDGEGTVVAGVTADIER 322 Query: 226 TGQGT---SGTLQVVNPHLWQPGEGYLY----ELCVTAKSQTEC---DIYPLRVGIRSVA 275 +G GT SG + + + LW PG YLY EL +++ D Y GIR+V Sbjct: 323 SGDGTAKASGEIAIRDAKLWNPGAAYLYTAVAELLPEGGAESSSRIIDAYRQTFGIRTVE 382 Query: 276 VKGEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAE 335 V G FLIN KPFYF GFG+HED+ G+G D+VL V D +L+ W+ ANS+RTSHYPYAE Sbjct: 383 VSGTTFLINGKPFYFKGFGKHEDSYFHGRGTDDVLNVKDVSLIHWLHANSFRTSHYPYAE 442 Query: 336 EMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKEL 395 M D D GIV+IDE AVG + + N + H +AI+ + Sbjct: 443 SMYDLCDREGIVIIDEVPAVGMSWL-----------------QYANPLVAERHREAIRGM 485 Query: 396 IARDKNHPSVVMWSIANEPDT-----RPQGAREYFAPLAEATRKLDP-TRPITCVNVMFC 449 IARDKNHP +VMWSIAN P RP+ A +YF PL E DP RP+T V Sbjct: 486 IARDKNHPCIVMWSIANAPGLDGDGERPRQAYDYFRPLYELAHASDPQNRPVTLVCCQ-N 544 Query: 450 DAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDT 509 D TD DV+C+NRYYGWY SGDL+ A L EL W E + +P++ TEYG DT Sbjct: 545 DYTTDITERTMDVVCINRYYGWYNLSGDLDAACHALNIELDFW-ENIGKPVMFTEYGADT 603 Query: 510 LAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKG 569 + G+H + +M+SEE+Q + + D+ +GEQ+WNFADFAT QGI+RV GN+KG Sbjct: 604 IEGIHGTHGEMFSEEFQRDYYARINAEIDKRPWFIGEQLWNFADFATFQGIIRVEGNRKG 663 Query: 570 IFTRDRKPKSAAFLLQKRWTGM-NFGEK 596 I TRDR+PK AA L++RW G+ ++G K Sbjct: 664 ILTRDRQPKMAAHWLRERWAGIPDYGYK 691 >6D89-C nrPDB Length = 595 Score = 181 bits (460), Expect = 6e-46, Method: Compositional matrix adjust. Identities = 161/614 (26%), Positives = 267/614 (43%), Gaps = 99/614 (16%) Query: 10 REIKKLDGLWAFSLDRENCGIDQRWWE-------SALQE-----SRAIAVPGSFNDQFAD 57 R+ LDG W +D G + ++ + LQE + + VPG +N Q Sbjct: 34 RQTTSLDGQWKTIVDPFENGRGMKVYQDKTYSDKTKLQEYDFETDKLLFVPGDWNTQ--R 91 Query: 58 ADIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEAD 117 + Y G VWY R+ F G+R+ L F AV + VW+N + + H GG+TPF + Sbjct: 92 PQLYYYEGTVWY-RKHFEYSLQPGKRLFLNFGAVNYEAIVWLNGKRLGRHIGGFTPFNFE 150 Query: 118 VTPYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLY 177 +T + G + + V V+N+ + +P + D++N+ GI R V L Sbjct: 151 ITNLLKEGTN-SLVVKVDNKRLPEAVP--------------TVNADWWNFGGITRPVTLI 195 Query: 178 TTPNTWVDDITVVTHVAQDCNHASVDWQVVANGD------VSVELRDADQQVVATGQGTS 231 P T++ D V +A+D + W + D + + ++V G + Sbjct: 196 EMPATYIRDYYV--QLAKDDKNMIEGWVQLEGSDKEQKITLDIPELKVKKEVTTDANGYA 253 Query: 232 GTLQVVNPHLWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFT 291 L P LW P LY + + +++ D +G R++ +G + L+N K + Sbjct: 254 SFLIKSKPILWTPENPKLYAVNLASETDKVSD----EIGFRTIRTEGIKILLNDKEIFCR 309 Query: 292 GFGRHEDAD-LRGKGFDNVLMVHDHALMDW---IGANSYRTSHYPYAEEMLDWADEHGIV 347 G HE+ G+ + H H L+ W +G N R +HYP+ EEM+ A+ G + Sbjct: 310 GISIHEETPYYSGRAYSK---DHAHTLLSWAKELGCNFVRLAHYPHNEEMVREAERMGFL 366 Query: 348 VIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVM 407 V E ++ N +T Q Q + ++IARDKN ++++ Sbjct: 367 VWSEIPV-------------------YWTIHWENKDTYQNAEQQLCDMIARDKNRCNIII 407 Query: 408 WSIANE-PDTRPQGAREYFAPLAEATRKLDPTRPITCV--------NVMFCDAHTDTISD 458 WSIANE P ++ + + + LA R LD R I V+ + D + + Sbjct: 408 WSIANETPHSKTRLT--FLSNLANKARSLDSVRLIGAAMEKEEVQPGVLTVN---DPLGE 462 Query: 459 LFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYT 518 L D++ N Y GWY GD E ++V W +P+ I+E G L G H Sbjct: 463 LLDIISFNEYVGWY--DGDSEKCDRV------NWTFDTQKPVFISELGGGALYGHHGSPK 514 Query: 519 DMWSEEYQCAWLDMYHR---VFDRVSAVVGEQVWNFADFATSQ---GILRVGGNKKGIFT 572 + ++EEYQ D+Y R + R+ + G W DF + + ++ N+KG+ + Sbjct: 515 ERFTEEYQE---DLYIRHVNMLKRIPGLAGTTPWILKDFRSPRRHVPEIQDDFNRKGLVS 571 Query: 573 RDRKPKSAAFLLQK 586 + K A F+LQK Sbjct: 572 DKGQKKKAFFVLQK 585 >6D8K-A nrPDB Length = 597 Score = 179 bits (455), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 163/620 (26%), Positives = 277/620 (44%), Gaps = 89/620 (14%) Query: 10 REIKKLDGLWAFSLDRENCGIDQR------------WWESALQESRAIAVPGSFNDQFAD 57 R+I+ L+G W +D + G + ++E + Q + VPG +N Q Sbjct: 33 RDIRSLNGKWNAIIDLYDQGRGMKVYRNQSPKGNTDFYEYSFQGGLRLNVPGDWNSQ--T 90 Query: 58 ADIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEAD 117 +++ Y G VWY R F K +R L F AV++ +V++N E+ H+GG+TPF+ + Sbjct: 91 PELKYYEGTVWYARH-FDAKRLTHKRQFLYFGAVSYRCRVYLNGAEIGSHEGGFTPFQIE 149 Query: 118 VTPYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLY 177 VT + G++ I + VNN IP + D++NY GI R V+L Sbjct: 150 VTDLLNEGENF-IAIEVNNRRTKDAIP--------------AMSFDWWNYGGITRDVLLV 194 Query: 178 TTPNTWVDDITV-VTHVAQDCNHASVDWQVVANGD---VSVELRDADQQVVATGQGTSGT 233 TTP T+++D + + + + A V G+ VS+ ++ +G + T Sbjct: 195 TTPQTYLEDYFIQLDKESPNRMIAKVALSDKKAGEKITVSIPELKTSIDMLTDAEGKAET 254 Query: 234 L-QVVNPHLWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTG 292 + + W LYE+ V++ + D ++G R++ VKG +N KP + Sbjct: 255 VFNIKKLERWSSENPKLYEVIVSSAN----DRVEEQIGFRNITVKGTDIYLNGKPTFMCS 310 Query: 293 FGRHEDADLR-GKGF---DNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVV 348 HE+ R G+ F D +++++ + G N R +HYP E + A++ G ++ Sbjct: 311 ISFHEEIPQRMGRAFSEADAAMLLNEAKAL---GVNMIRLAHYPQNEYTVRLAEKMGFIL 367 Query: 349 IDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMW 408 E + GI F N T++ + + E+I RD+N +V W Sbjct: 368 WQEIP-----VWQGIDF--------------TNNNTRKKAQRMLSEMIKRDQNRCAVGYW 408 Query: 409 SIANEPDTRPQGAR-EYFAPLAEATRKLDPTRP-ITCVNVMFCDAHT------DTISDLF 460 IANE T+P AR E+ L E ++LD TR + +++ + D+ + Sbjct: 409 GIANE--TQPSKARNEFLTSLLETGKQLDTTRLYVAAFDLVRFNREKKRFVMEDSFTSQL 466 Query: 461 DVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLH--SMYT 518 DV+ +N+Y GWY +E E W+ +P+II+E+G + L G Sbjct: 467 DVVAVNKYMGWY--------HPWPIEPENAVWEVIPDKPLIISEFGGEALYGQSGDENVA 518 Query: 519 DMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATS---QGILRVGGNKKGIFTRDR 575 WSEEYQ R+FD + + G W DF + + G N+KG+ + D+ Sbjct: 519 SSWSEEYQARLYRDNIRMFDNIPNLRGVSPWILFDFRSPFRFHPTNQDGWNRKGLVS-DQ 577 Query: 576 KPKSAAFLLQKRWTGMNFGE 595 + A+ L + + FGE Sbjct: 578 GIRKKAWYLMREYYKTKFGE 597 >6NCZ-A nrPDB Length = 610 Score = 177 bits (450), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 153/609 (25%), Positives = 270/609 (44%), Gaps = 83/609 (13%) Query: 15 LDGLWAFSLDRENCGIDQRWWESALQESRAIAVP--GSFND----------QFADADIRN 62 L+G W +++D+ + + Q+W++ ++ + VP SF++ D Sbjct: 43 LNGGWHYAVDQYDTCLRQKWYKERYRDEKGFTVPIDYSFDEWPVMQLPCSWNTIDPMYLL 102 Query: 63 YAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYV 122 Y G++ + R+ F + + L+ A + +V++N + V H+GG TP ++T Y+ Sbjct: 103 YEGSMVFTRK-FSYIAEREETVFLKVGAANYLCRVFLNGKYVGMHRGGSTPAFWNITEYL 161 Query: 123 IAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNT 182 A RI + V+ + +P EN D+FNY G++R + L P Sbjct: 162 KAEN--RIVLAVDGTRRPEQVPT------ENT--------DWFNYCGVYRDIALIRVPKC 205 Query: 183 WVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVVN---- 238 + + + D V +V + ++ A ++V G S +Q+ N Sbjct: 206 HIKTFKIA--LVPDGTFGHVMAKVTLSEKIT-----AKAELVIEELGVSRKIQLENGAGE 258 Query: 239 ------PHLWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTG 292 P LW P + LY++ VT + T D RVG R + V G L+N +P + G Sbjct: 259 VVFDAKPELWTPEKPKLYDVKVTCGTDTVSD----RVGFREIRVNGRDILLNGEPVFLRG 314 Query: 293 FGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDET 352 HED+ GKG + + + +G N R +HYP+ EEM ADE G+++ +E Sbjct: 315 ISCHEDSVENGKGLTREERIENIRIAKELGCNFMRLAHYPHNEEMAKLADELGLLLWEEI 374 Query: 353 AAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIAN 412 + I FE +E E+A N ++ELI RD N SV++WS+ N Sbjct: 375 P-----VYWAIRFE-----REKTYEDAQN---------QLRELINRDWNRASVIIWSVGN 415 Query: 413 EPDTRPQGAREYFAPLAEATRKLDPTRPIT--CVNVMFCDAHTDTISDLFDVLCLNRYYG 470 E + + + + LAE + D TR ++ C+ + D + + D++ +N Y G Sbjct: 416 ENADTDERLK-FMSVLAECAHREDETRMVSAACLVNAAKNKIEDRLMEYLDIIGINEYCG 474 Query: 471 WYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWL 530 WY + D ++E + +P+I+TE+G D L H +D +EE Q Sbjct: 475 WY--TPDFAMLPALME------NSQPDKPVIVTEFGADALPHHHGTISDKGTEECQADVY 526 Query: 531 DMYHRVFDRVSAVVGEQVWNFADFATSQ--GILRVGGNKKGIFTRDRKPKSAAF-LLQKR 587 + + + G W DF + +++ N+KG+ + D+K + AF +LQK Sbjct: 527 EKQIATLRNIDYIKGMTPWILYDFRCPRRTSLIQKYYNRKGLLSEDKKYRKPAFYVLQKF 586 Query: 588 WTGMNFGEK 596 + + E+ Sbjct: 587 YEELKRKEQ 595 >6D8G-A nrPDB Length = 886 Score = 176 bits (446), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 169/641 (26%), Positives = 274/641 (42%), Gaps = 105/641 (16%) Query: 1 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESR--AIAVPGSFN-DQFAD 57 +L PV R+ + ++ W F D SA +S+ +I +P ++N D + + Sbjct: 25 VLPPVHA-QRQTQTINDSWKFLKGECTAAAD-----SAFDDSKWTSIHLPHTWNTDAYTE 78 Query: 58 ADIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEAD 117 D Y G WY+R++ +P+GW ++I+LR DA +++N + V EH GGYT + Sbjct: 79 KDY--YRGTGWYRRQLTLPQGWKEKQIILRLDAAGKSATIYINGKNVGEHAGGYTACSFN 136 Query: 118 VTPYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLY 177 +TP++ + VCV+N Q I P DF + GI+R V L Sbjct: 137 ITPFLSFDTPNTLAVCVDNAR--QDIAP--------------ISGDFTFFGGIYRDVWLT 180 Query: 178 TTPNTWV-------DDITVVT-HVAQDCNHASVDWQVV--ANGDVSVEL----------- 216 PN D + + T V+++ S+ +V A ++EL Sbjct: 181 AVPNQHFNLTNHGSDGLFISTPQVSEEQATLSIRGEVKNDAPEKATLELTHTIYRPDGTL 240 Query: 217 -----RDADQQVVATGQGTSGTLQVVNPHLWQPGEGYLYELCVTA---KSQTECDIYPLR 268 ++ + T ++ V+ P LW P LY + T K++T D Sbjct: 241 LQTLKKNIQLKAGETYAFSNEATPVLKPELWTPETPRLYRVETTLRNRKTKTLLDQSNHY 300 Query: 269 VGIRSVAVKGEQ-FLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYR 327 R G++ F +N KP+ G RH+D G + D LM +GAN R Sbjct: 301 TAFRWFRFDGDEGFFLNGKPYKLRGICRHQDQKPIGPALTAEMHRRDFLLMKEMGANFIR 360 Query: 328 TSHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQA 387 SHYP A+ +L+ D+ G++ +E + N P G+ + Sbjct: 361 ISHYPQADALLEMCDKLGMLAWEEIPIIDI---------VPNTPGY--------GDNCER 403 Query: 388 HLQAIKELIARDKNHPSVVMWSIANE---PDTRPQGAREYFAPLAEATRKL--------- 435 +L +E+I + NHPS++ W NE R P+ E T L Sbjct: 404 NL---REMIRQHYNHPSIITWGYMNEILLVTQRKYKTEAELKPVLERTLALANRLERVLK 460 Query: 436 --DPTRPITCVNVMFCDAHTDT-ISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAW 492 D TR I+ + +++ +T +S + D++ N Y GWY GDL EK L ++ Sbjct: 461 EEDSTR-ISTMAFHGSNSYNETGLSKITDIVGWNLYQGWY--GGDLTGFEKFLAQQ---H 514 Query: 493 QEKLHQPIIITEYGVDTLAGLHSMYTDM--WSEEYQCAWLDMYHRVFDRVSAVVGEQVWN 550 Q P+I++EYG + LHS++ +S EYQ +L+ Y V + + G WN Sbjct: 515 QNHPTHPMIVSEYGAGSDKRLHSLHPRAFDFSIEYQQKYLEHYLPVLEDTPYICGGTHWN 574 Query: 551 FADFATS---QGILRVGGNKKGIFTRDRKPKSAAFLLQKRW 588 F DF+++ + + R+ N KG+ DR PK Q W Sbjct: 575 FIDFSSALRDESMPRI--NNKGLVYADRTPKDVYHYYQAAW 613 >6ED1-A nrPDB Length = 879 Score = 155 bits (391), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 147/573 (25%), Positives = 232/573 (40%), Gaps = 93/573 (16%) Query: 65 GNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIA 124 G WY++++FIP ++I LRFD V V++N + + H G YT F D+T Sbjct: 77 GISWYRKKLFIPSEARDKKITLRFDGVASKADVYLNGKLLKTHLGAYTAFGVDITDICEV 136 Query: 125 GKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVML-------- 176 GK + V V+N + I P + DF + GI+R V L Sbjct: 137 GKENLLAVKVDNSSSLGEILPPVS-------------GDFSIFGGIYRRVFLQWTEKVHF 183 Query: 177 -----------YTTPNTWVDD-----ITVVTHVAQDCNHASVDW-------QVVANGDVS 213 TP V + + + + D H V+ ++V + Sbjct: 184 VTEPYAAVPVRIQTPEVSVSEASMQIVAFLKNDFTDTKHVHVNVFLCDEMNRIVKEKQLK 243 Query: 214 VELRDADQQVVATGQGTSGTLQVVNPHLWQPGEGYLYELCVTAKSQTECDIYP---LRVG 270 ++L + ++T G ++ NPHLW P YLY + V ++Y VG Sbjct: 244 LKLIPGRKYPISTSVG-----RIENPHLWSPELPYLYTVKVQVCDAKNGEMYQEVISPVG 298 Query: 271 IRSVAVKGEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSH 330 R +V F +N K G RH+D G + D L+ +GAN R SH Sbjct: 299 FRWFSVDKTGFYLNGKYLKLRGAARHQDYAGLGTAIPVEMNRRDMRLLKEMGANFVRISH 358 Query: 331 YPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAH-- 388 YP E+ DE G++V E V V T AH Sbjct: 359 YPQDPEIYRACDELGLIVWSEICVVN----------------------EVRKNTAFAHNC 396 Query: 389 LQAIKELIARDKNHPSVVMWSIANEPDTRPQGAREYFAPLAEATRKLDPTRPITCV---N 445 + +KE+I ++ NHPSVV+W NE + A L ++LDP R ++CV Sbjct: 397 KEMLKEMILQNYNHPSVVLWGAMNELWDYHKQAIALARELEALKKELDPYR-LSCVAFHA 455 Query: 446 VMFCDAHTDTISDLF---DVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIII 502 + +T + ++F DV +N Y WY GD T + +K +P + Sbjct: 456 FTWEKPYTQSSKEMFSISDVNGVNVYESWY--QGDSATIAPMFDK---FCSYSTAKPRFL 510 Query: 503 TEYGVDTLAGLHSMYTDM---WSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFAT-SQ 558 +E+G + +HS YT ++ E+Q + Y ++ +G +WN DF + Sbjct: 511 SEFGAGSDERIHS-YTPRTFDFTPEFQLDFNRRYINEMEKRPDYIGYSIWNLVDFQVDGR 569 Query: 559 GILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGM 591 G + N+KG+ T DR+ K + Q RW+ + Sbjct: 570 GDSKPNLNQKGMLTEDRRKKEIYYYCQARWSDI 602 >6NCW-A nrPDB Length = 574 Score = 154 bits (390), Expect = 8e-38, Method: Compositional matrix adjust. Identities = 163/574 (28%), Positives = 229/574 (39%), Gaps = 86/574 (14%) Query: 47 VPGSFNDQFADADIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVME 106 VPG + + D +Y G Y RE F KG I L F V+H V V+ + V Sbjct: 39 VPGCWENY---PDTVSYRGQASYSRE-FEAKG----NIRLEFKGVSHTASVLVDGKPVGS 90 Query: 107 HQGGYTPFEADVTPYVIAGKSVRITVCVNNELNWQTIPPGM----VITDENGKKKQSYFH 162 H YTPF+ + K +R PG+ VI D N S H Sbjct: 91 HYNAYTPFD-------VVLKDIR---------------PGIHQLEVIAD-NSFGPDSALH 127 Query: 163 ---DFFNYAGIHRSVMLYTTPNTWVDDITVVTHVAQDCNHASVDWQVV------ANGDVS 213 D+ +Y GI R V+L ++ I + +D + + V +G V Sbjct: 128 VPNDYQSYGGISRGVVLEELGEAYLSWIHFTPFLRKDGWYGKAEICVRNLSSGRLDGSVE 187 Query: 214 VELRD---ADQQVVATGQ--GTSGTLQVVNP--HLWQPGEGYLYEL-CVTAKSQTECDIY 265 VE+ A +V G+ + T ++ P W P LY + V + D Sbjct: 188 VEIGKNSFAVLPIVLEGEEEKSFSTEELPCPWAECWSPESPVLYLITAVLRTADGAADDI 247 Query: 266 PLRVGIRSVAVKGEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANS 325 RVG R + +G+ L+N + GF RHED G M HD L+ +GANS Sbjct: 248 IDRVGFREIRTEGKDILLNGRKLRIKGFCRHEDHPQFGCALPFSAMQHDLMLIKDLGANS 307 Query: 326 YRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQ 385 RT HYP E LD DE GI+V +E A G L E N + Sbjct: 308 IRTVHYPNDELFLDLCDEQGILVWEENHARG-----------------LSEENMRNPHFK 350 Query: 386 QAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQGAREYFAPLAEATRKLDPTRPITCVN 445 Q I+E+I NHPS+ +W I NE + + RE ++ E + LDP RP + + Sbjct: 351 QQCGDCIREMITAHYNHPSIYIWGILNECASDTEYGRECYSEQYELIKSLDPYRPRSSAS 410 Query: 446 VMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAW----QEKLHQPII 501 C TD +V+ N Y WY D+ + + EL W E +P + Sbjct: 411 ---CRFKTDICLGYPEVVSYNIYPKWY---HDVPVEDYL--DELYQWIQNESEGTGKPFL 462 Query: 502 ITEYGVDTLAGLHSMYTDMWSEEYQCAWL-DMYHRVFDRVSAVVGEQVWNFADFATSQ-- 558 ITE G + G + WSEEYQ L + VF R G +W F D Sbjct: 463 ITEIGAGAIYGYRTPAHVKWSEEYQVQALKEQLQAVFSR-EGCSGVYIWQFCDVRVCDSW 521 Query: 559 -GILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGM 591 G N KGI R+PK A +++ + + Sbjct: 522 FGSRPRTMNNKGIVDEYRRPKLAYEVVKDSYRSL 555 >3CMG-A nrPDB Length = 667 Score = 151 bits (381), Expect = 9e-37, Method: Compositional matrix adjust. Identities = 153/590 (25%), Positives = 236/590 (40%), Gaps = 90/590 (15%) Query: 41 ESRAIAVPGSFNDQFADA---DIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKV 97 ++R + +P ++N Q A A D + GN Y++ ++I W G+R+ LRFD V V Sbjct: 24 DTRRVDLPHTWNAQDALAGKIDYKRGIGN--YEKALYIRPEWKGKRLFLRFDGVNSIADV 81 Query: 98 WVNNQEVMEHQGGYTPFEADVTPYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKK 157 ++N + + EH+GGY F ++T V G+ + V NN +P Sbjct: 82 FINRKHIGEHRGGYGAFIFEITDLVKYGEKNSVLVRANNGEQLDIMP------------- 128 Query: 158 QSYFHDFFNYAGIHRSVML------------YTTPNTWVDDITVVTHVAQDCNHASVDWQ 205 DF Y GI+R V L Y +P ++ V A+ C ++ Sbjct: 129 --LVGDFNFYGGIYRDVHLLITDETCISPLDYASPGVYLVQEVVSPQEAKVCAKVNLS-N 185 Query: 206 VVANGDVSVELRDADQQVVATGQGTSGTLQ------------VVNPHLWQPGEG-YLYEL 252 A+G +++ D V + + +L+ + P LW E ++Y++ Sbjct: 186 RAADGTAELQVLVTDGTKVICKESRNVSLKQGADILEQLPLLIQKPRLWNGCEDPFMYQV 245 Query: 253 CVTA-KSQTECDIYPLRVGIRSVAVKGEQ-FLINHKPFYFTGFGRHEDADLRGKGFDNVL 310 ++ K + D +G+R ++ F +N K G RH+D G Sbjct: 246 SISLHKDGKQIDSVTQPLGLRYYHTDPDKGFFLNGKHLPLHGVCRHQDRAEVGNALRPQH 305 Query: 311 MVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNK 370 D ALM +G N+ R +HYP A M D D+HGIV E VG GF Sbjct: 306 HEEDVALMREMGVNAIRLAHYPQATYMYDLMDKHGIVTWAEIPFVGPGGYADKGFVDQAS 365 Query: 371 PKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQGAREYFAPLAE 430 +E NG+ Q + ELI + NHPS+ W + NE EY L Sbjct: 366 FRE-------NGKQQ------LIELIRQHYNHPSICFWGLFNELKEVGDNPVEYVKELNA 412 Query: 431 ATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELL 490 ++ DPTRP T + D + + I+ + + NRY GWY + K L Sbjct: 413 LAKQEDPTRPTTSASNQ--DGNLNFIT---ENIAWNRYDGWYGST----------PKTLA 457 Query: 491 AWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCA--------WLDMYH----RVFD 538 + ++ H+ G+ S+Y S + A W YH ++ Sbjct: 458 TFLDRTHKKHPELRIGISEYGAGASIYHQQDSLKQPSASGWWHPENWQTYYHMENWKIIA 517 Query: 539 RVSAVVGEQVWNFADFATSQGIL--RVGGNKKGIFTRDRKPKSAAFLLQK 586 V G VWN DF + R G N KG+ T DRK + AF K Sbjct: 518 ERPFVWGTFVWNMFDFGAAHRTEGDRPGINDKGLVTFDRKVRKDAFYFYK 567 >6MVG-A nrPDB Length = 777 Score = 148 bits (373), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 161/614 (26%), Positives = 253/614 (41%), Gaps = 96/614 (15%) Query: 10 REIKKLDGLWAFSLD--RENCGIDQRWWESALQES-RAIAVPGSFNDQFADADIRNYAGN 66 REI L+ WAFS + + + Q W+ L + AI ND Y G Sbjct: 25 REIFNLNEKWAFSKEAIKPPVAMPQNWYWVNLPHTWNAIDGQDGGNDY--------YRGT 76 Query: 67 VWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIAGK 126 +Y +EV + G++ L F V V+VN + H GGY+ + ++T + GK Sbjct: 77 CFYAKEVQKEELPEGEQYYLEFLGVNASADVYVNGNHLDHHDGGYSTWRVNMTDALTDGK 136 Query: 127 SVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNTWVD- 185 ++ I V V+N N + P DF Y G++R V + + D Sbjct: 137 NL-IVVAVDNSANDRVYPQKA---------------DFTFYGGMYRDVNIIAVNKSHFDL 180 Query: 186 ------DITVVTHVAQDCNHASVDWQVVANGD-----VSVELRDADQQVVA-TGQGTSG- 232 + V VA +A + +V +G+ + ++ DA+ + A T G S Sbjct: 181 DYYGGNGLKVTPEVAD--KNAKIAVEVFLSGEKAGQQLVYQITDAEGVLAAETKTGISDK 238 Query: 233 --TLQVVNPHLWQP-GEGYLYELCVTAKSQTEC-DIYPLRVGIRSVAVKGEQ-FLINHKP 287 L++ + HLW + YLY V C D R G R+ + ++ F +N Sbjct: 239 QVNLEITDVHLWNGRKDPYLYTATVRLMEDGVCIDSVSTRFGCRTFTIDPDKGFFLNGNS 298 Query: 288 FYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIV 347 + G RH+D G D L+ +GA + R +HY +A+ D DE G+V Sbjct: 299 YPLRGVSRHQDRAGNGNALLPEHHREDIDLICEMGATTIRLAHYQHAQYFYDLCDEKGLV 358 Query: 348 VIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVM 407 + E + S+ NG ++ + +KELI ++ NHPS+V+ Sbjct: 359 LWAEIPYI--------------------SQHMKNG--RENTISQMKELIVQNYNHPSIVV 396 Query: 408 WSIANEPDTRPQGAREYFAP---LAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLC 464 W ++NE + + L + ++DPTR T V CD H I + DV+ Sbjct: 397 WGLSNEITMSGEADEDLMENHHILNDLAHEMDPTRLTTMAVVSMCDMHNPYIQ-IPDVVS 455 Query: 465 LNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQ-----PIIITEYGVDTLAGLHSMYTD 519 N Y+GWY GD W ++ H+ PI ++EYG + L H+ Sbjct: 456 YNHYFGWY--GGDTSMNG--------PWMDEFHKEFPKIPIGMSEYGCEAL-NWHTSDPK 504 Query: 520 M--WSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFAT---SQGILRVGGNKKGIFTRD 574 ++EEYQ + + + + VWN DFA ++G G N KG+ T D Sbjct: 505 QGDYTEEYQAHYHEELIKQLYTRPYIWATHVWNMFDFAADARNEG-GENGMNHKGLVTFD 563 Query: 575 RKPKSAAFLLQKRW 588 RK K AF K W Sbjct: 564 RKYKKDAFYAYKAW 577 >6MVF-A nrPDB Length = 769 Score = 134 bits (336), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 148/545 (27%), Positives = 224/545 (41%), Gaps = 93/545 (17%) Query: 81 GQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIAGKSVRITVCVNNELNW 140 G R+ + A V VN H+GG++ F AD+T G + +T+ V+NE Sbjct: 86 GGRVYVEVLAAALDATVKVNGTVATTHEGGFSIFRADITDLCRDGDN-ELTIEVSNEDTP 144 Query: 141 QTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNTWVD-------DITVVTHV 193 P DF Y G++R V L + PN D I V Sbjct: 145 SMYPASA---------------DFTFYGGLYRGVNLISVPNAHFDLDYYGGPGIMVTPKP 189 Query: 194 AQDCNHASVDWQVVANGDVSVELRDADQ--------QVVATGQGTSGTLQVVNPHLWQPG 245 D V N D S + + + V T+ ++ V + LW Sbjct: 190 TADGGATFEIKSFVTNPDDSFTVMYSIEDPYGCEVASAVRPSDNTAISIYVPDAELWSMD 249 Query: 246 EGYLYELCVTAKSQTEC--DIYPLRVGIRSVAVKGEQ-FLINHKPFYFTGFGRHEDADLR 302 E LY + + E +IY VG+RS V + F IN + G RH+D + Sbjct: 250 EPNLYTVVARLQRNNEAFDEIYA-NVGVRSYTVTPDGGFSINGEATPLRGVSRHQDKLYK 308 Query: 303 GKGFDNVLMVHDH----ALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFN 358 G N L V DH ++ +GAN+ R +HY ++++ D DE G V E + Sbjct: 309 G----NALTVEDHYQDAQIIKELGANTIRLAHYQHSQDFYDACDELGFAVWAEIPFISV- 363 Query: 359 LSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANE--PDT 416 F++G EE +KELI ++ NHPS++ W I+NE Sbjct: 364 ------FKSGKDAHTHVMEE-------------MKELIIQNYNHPSILFWGISNEILIGG 404 Query: 417 RPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDT---ISDLFDVLCLNRYYGWYV 473 Q + L + ++LDPTR T +V +HT T + + DV N Y+GWY Sbjct: 405 ISQELVDTHHDLQKLCKELDPTRLTTIAHV----SHTPTSGPMHRITDVESYNHYFGWY- 459 Query: 474 QSGDLETAEKVLEKELLAWQEKLH--QPII---ITEYGVDTLAGLHSMYTDM--WSEEYQ 526 G +E + W +K H P I I+EYG + + HS +SEEYQ Sbjct: 460 -GGKIE--------QNGPWLDKFHAENPDICLGISEYGCEGIINWHSNTPQCKDYSEEYQ 510 Query: 527 CAWLDMYHRVFDRVSAVVGEQVWNFADF---ATSQGILRVGGNKKGIFTRDRKPKSAAFL 583 + + + F+ + VWN DF A S+G ++ G N KG+ T DRK + +F Sbjct: 511 ALYHEYMAQAFEDRPWIWASHVWNMFDFGCAARSEGGVK-GRNNKGLVTIDRKTRKDSFY 569 Query: 584 LQKRW 588 + + + Sbjct: 570 VYQAY 574 >6DXU-D nrPDB Length = 830 Score = 133 bits (334), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 150/622 (24%), Positives = 244/622 (39%), Gaps = 118/622 (18%) Query: 43 RAIAVPGSFNDQFA-DADIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNN 101 + + +P FN + A D D+ Y G WY+ + I + RIVL FD V+V Sbjct: 66 QPVTLPHCFNAEDAVDPDVNYYEGPGWYKTLLAIDNPYRNGRIVLDFDGAGQKTDVYVYT 125 Query: 102 QEVMEHQGGYTPFEADVTPYVIA-----------GKSVRITVCVNNELNWQTIPPGMVIT 150 V H GGY + D+T V A GK V +++ +N + + IP + Sbjct: 126 THVGSHVGGYDSWNVDITDAVKAFLGSKDAERFKGK-VPLSIRCDNSRDLEMIPSDLA-- 182 Query: 151 DENGKKKQSYFHDFFNYAGIHRSVMLYTTPNTWVDDITVVTHVAQDCNHASVDWQV---- 206 DF Y G++R + L P + I + + ++ + + + Sbjct: 183 ------------DFNIYGGLYRYLNLVYLPEVSFEQIHLESSLSSNLKEGILKVKTSFYN 230 Query: 207 ---VANGDVSVELRDADQQ---------VVATGQGTSGTLQVVNPHLWQPGEGYLYELCV 254 + DV+V + D D++ ++ G +++ NP LW LY + Sbjct: 231 PEDIRKADVTVSVYDVDRKPVFSKTLEGILPLGDQLLAKMKIKNPVLWDVDVPQLYTCEL 290 Query: 255 TAKSQTECDIYPLRVGIRSVAVKGE-QFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVH 313 T K+ + R G R K + F +N K G RHED + +M Sbjct: 291 TVKTPDQTFTTEERFGFRHTEFKDKGPFFLNGKRLLLRGTHRHEDHAGVAQAMTEDMMRR 350 Query: 314 DHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKE 373 + +M +G N R HY +E +LD DE GI+V +E I + G + Sbjct: 351 EMRMMKDMGVNFIRLGHYQQSEIILDLCDELGILVWEE-----------IPWCRGGLGGD 399 Query: 374 LYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPD------TRPQGA-REYFA 426 +Y ++A + + +I + NHP+V++W + NE D T + A R + Sbjct: 400 VYKKQA---------RRMLANMIVQHHNHPAVIIWGLGNENDWPNDFNTFDKSAIRAFMK 450 Query: 427 PLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLE 486 L + +LD TR FC+ D+ DV + + GWY G + + E Sbjct: 451 ELHDMAHRLDDTRMTAIRRCEFCN-------DIVDVYSPSIWAGWY--RGVFTDYKSISE 501 Query: 487 KELLAWQEKLH-------------------QPIIITEYGVDTLAGLHSMYTDM------- 520 +E+ + LH I G D AG S+Y + Sbjct: 502 QEMQKVKHFLHVEWGGDSHARRHSEDAFYNLKNIEAGKGGDERAGDASLYGGVPRASRDG 561 Query: 521 -WSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFAT----SQGILRVGGNKKGIFTRDR 575 WSE Y +D + + + + + G W F DF+T + V N+KG+ RD Sbjct: 562 DWSESYVVRLIDWHLKEQETMPWLTGTAYWPFKDFSTPVRPDNPVPYV--NQKGVVERDF 619 Query: 576 KPKSAAFLLQKRWTGMNFGEKP 597 PK + ++ Q WT EKP Sbjct: 620 TPKESYYVFQSYWT-----EKP 636 >6MVH-A nrPDB Length = 780 Score = 132 bits (333), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 151/619 (24%), Positives = 255/619 (41%), Gaps = 106/619 (17%) Query: 10 REIKKLDGLWAFSLDRENCG--IDQRWWESALQESRAIAVPGSFND-QFADADIRNYAGN 66 RE+ + WAF+ + + ++W+ + +P S+N+ D Y G Sbjct: 25 REVINFNTKWAFTKEATEVPKEMPEKWY--------WVTLPHSWNEIDGQDGGNDYYRGT 76 Query: 67 VWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIAGK 126 +Y +++ + L V+VN + V H GGY+ + D+T + + Sbjct: 77 CYYAKQLKKSELPEADCYYLELRGANASADVYVNGKAVAHHDGGYSTWRVDITKELTEEE 136 Query: 127 SVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNTWVD- 185 ++ I + V N +N + P DF Y G++R V + + D Sbjct: 137 NL-IVIAVENGVNDRVYPQNA---------------DFTFYGGLYRDVNIIAVNKSHFDL 180 Query: 186 ------DITVVTHVAQDCNHASVDWQV-----VANGDVSVELRDADQQVVATGQGTSG-- 232 I V + ASV+ +V A+ + ++DA+ + VA + +G Sbjct: 181 DYYGGPGIKVTPEIK--GADASVEVEVFLTNAAADQKLVYTVKDAEGKEVAKTETAAGET 238 Query: 233 --TLQVVNPHLWQ-PGEGYLYELCVTAKSQTEC-DIYPLRVGIRSVAVKGEQ-FLINHKP 287 L + HLW + YLY V S E D R G R+ + E+ F++N + Sbjct: 239 KAVLSIPAVHLWNGKKDPYLYTAEVALVSGEEAVDAVSTRFGCRTFEIDPERGFILNGEE 298 Query: 288 FYFTGFGRHEDADLRGKGFDNVLMVHDHA----LMDWIGANSYRTSHYPYAEEMLDWADE 343 + G RH+D G N L+ H L+ +GA + R +HY + + D DE Sbjct: 299 YPLRGVSRHQDR----WGIGNALLPEHHREDIDLICELGATTIRLAHYQHDQYFYDLCDE 354 Query: 344 HGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHP 403 G+V+ E + ++ G ++ + +KEL+ ++ NHP Sbjct: 355 RGLVIWAEIPYISSHMPNG----------------------RENTISQMKELVVQNYNHP 392 Query: 404 SVVMWSIANE---PDTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLF 460 S+V+W ++NE + + E L + ++D TR T V CD H D + Sbjct: 393 SIVVWGLSNEITMAGSSDEDLLENHRILNDMVHEMDHTRLTTIAVVSMCDIH-DPYIQIP 451 Query: 461 DVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQ-----PIIITEYGVDTLAGLHS 515 DV+ N Y+GWY GD+ W + H+ P+ ++EYG + L H+ Sbjct: 452 DVISYNHYFGWY--GGDVSMNG--------PWMDNFHKEFPNIPLGMSEYGCEAL-NWHT 500 Query: 516 MYTDM--WSEEYQCAWL-DMYHRVFDRVSAVVGEQVWNFADF---ATSQGILRVGGNKKG 569 ++EEYQ + +M ++F R + VWN DF A ++G G N KG Sbjct: 501 SDPKQGDYTEEYQAYYHEEMIKQLFTR-KYIWATHVWNMFDFGADARNEG-GENGQNHKG 558 Query: 570 IFTRDRKPKSAAFLLQKRW 588 + T DRK K +F K W Sbjct: 559 LVTFDRKYKKDSFYAYKAW 577 >3FN9-A nrPDB Length = 692 Score = 132 bits (332), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 153/588 (26%), Positives = 237/588 (40%), Gaps = 115/588 (19%) Query: 63 YAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYV 122 Y G +Y++ F P G+R+ LRF+ V +V+VN + H+GGY+ F ++ + Sbjct: 58 YEGAGYYRKTQFFPHDLEGKRVFLRFEGVGACAEVYVNGKLAGTHKGGYSAFACEIGTAL 117 Query: 123 IAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNT 182 G I V +N+ IP + F Y GI+R V L T Sbjct: 118 KLGAENEIIVKADNKARPDVIPVNQNL--------------FGVYGGIYRPVWLIVTEQ- 162 Query: 183 WVDDITV-------VTHVAQDCNHASVDWQVVANGD--------VSVE--LRDADQQVVA 225 ++ITV V +D + S D V D V++E + + Q V Sbjct: 163 --NNITVTDCASPGVYITQKDVSKKSADITVKVKLDNAGLQPAAVTLENTIYTQEGQKVG 220 Query: 226 T--------GQGTS---GTLQVVNPHLWQ-PGEGYLYE-LCVTAKSQTECDIYPLRVGIR 272 T QGT T ++ NPHLWQ + YLY+ +C D +G+R Sbjct: 221 THSRSFDLSPQGTQTYLSTFKLKNPHLWQGRKDPYLYKVVCRLMADGKVIDEVVQPLGVR 280 Query: 273 SVA-VKGEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHY 331 V G+ F +N + + G RH+D G N D A + +GA + R +HY Sbjct: 281 KYEIVAGKGFFLNGEKYSMYGVTRHQDWWGLGSALKNEHHDFDLAAIMDVGATTVRFAHY 340 Query: 332 PYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQA 391 ++ + D G+++ E V ET+ A Q Sbjct: 341 QQSDYLYSRCDTLGLIIWAEIPCV---------------------NRVTGYETENAQSQ- 378 Query: 392 IKELIARDKNHPSVVMWSIANEPDTRPQGAREYFAPLAEATRKL----DPTRPITCVNVM 447 ++ELI + NHPS+ +W + NE +P EY A L + L DP R VN Sbjct: 379 LRELIRQSFNHPSIYVWGLHNEV-YQPH---EYTAALTRSLHDLAKTEDPDRYTVSVNGY 434 Query: 448 FCDAHTDTISDL-FDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKL-----HQPII 501 H D +L D+ +NRY+GWY EK ++ ++ W E+L +Q ++ Sbjct: 435 ---GHMDHPVNLNADIQGMNRYFGWY---------EKKIQ-DIKPWVEQLEKDYPYQKLM 481 Query: 502 ITEYGVDTLAGLHSMY--------TDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFAD 553 +TEYG D + Y + E +Q + + ++ +WN D Sbjct: 482 LTEYGADANLAHQTEYLGDALNWGKPFYPETFQTKTHEYQWSIIKDHPYIIASYLWNMFD 541 Query: 554 FATSQGILRVGG----NKKGIFTRDRKPKSAAFLLQKRWTGMNFGEKP 597 FA + GG N KG+ T DRK K ++ W N+ E+P Sbjct: 542 FAVP--MWTRGGVPARNMKGLITFDRKTKKDSYF----WYKANWSEEP 583 >5T99-A nrPDB Length = 822 Score = 131 bits (329), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 110/434 (25%), Positives = 181/434 (41%), Gaps = 22/434 (5%) Query: 46 AVPGSFNDQF-ADADIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEV 104 A+ G F+ ++ A + G WY++ W + + + FD KVW+N +V Sbjct: 64 AIEGPFDSKYNARCGGLPFHGTGWYRKTFIGDAQWKDKIVRIGFDGAMSEAKVWINGVKV 123 Query: 105 MEHQGGYTPFEADVTPYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDF 164 EH GYT FE D+T Y+ G+ + V + PG I + + + Sbjct: 124 GEHPYGYTGFEIDITKYLKIGEENVLAVQLTPRDLSSRWYPGAGIYRNVWLRVDNKV--Y 181 Query: 165 FNYAGIHRSVMLYTTPNTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVV 224 G++ + T V T V + ++ ++ +V + + + +V Sbjct: 182 IPEHGVYVTTPTVTKSKAVVQIETTVKNATFGNGKFNIRHSIINAQGETVAILNDNVEVA 241 Query: 225 ATGQG-TSGTLQVVNPHLWQPGEGYLYELCVTAKSQTE-CDIYPLRVGIRSVAVKGEQFL 282 A QG T + ++NP++W Y+Y+L + D Y GIR + + F Sbjct: 242 AGEQGKTLAYINMLNPNIWGQKNPYMYKLKTEIYDGKDLTDTYFTDFGIRKICFTKDGFF 301 Query: 283 INHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWAD 342 +N + F G H D G + +M +G N+ RTSH P + E LD D Sbjct: 302 LNGEKIRFNGVCLHHDNGPMGAAVNVRADERKLQIMKEMGVNAIRTSHNPPSPEFLDLCD 361 Query: 343 EHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNH 402 G+VV+DE + G+ LY +E + + LI RD+NH Sbjct: 362 RMGLVVLDEAFDEWTKAKVDNGY-------HLYFDEWSK--------KDLTSLIMRDRNH 406 Query: 403 PSVVMWSIANEPDTRPQGAREYFAP--LAEATRKLDPTRPITCVNVMFCDAHTDTISDLF 460 PSV+MWSI NE + + + LA+ R+LDPTRP TC + + ++ Sbjct: 407 PSVIMWSIGNEILEQSDKKKGFTVAKYLADICRELDPTRPSTCGFNYYPAPFDNNMAQQV 466 Query: 461 DVLCLNRYYGWYVQ 474 D+ +N G Y + Sbjct: 467 DIAGMNYKPGKYAE 480 >6D1P-A nrPDB Length = 814 Score = 128 bits (321), Expect = 9e-30, Method: Compositional matrix adjust. Identities = 139/607 (22%), Positives = 219/607 (36%), Gaps = 117/607 (19%) Query: 45 IAVPGSFNDQFA-DADIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQE 103 + +P FN + A D D+ Y G WY+ + I + R L F+ +V+V Sbjct: 67 VTLPHCFNAEDAVDPDVNYYQGPGWYRTMLNIENPYTNGRTCLEFEGAGQKTEVYVYTTR 126 Query: 104 VMEHQGGYTPFEADVTPYVIA-----------GKSVRITVCVNNELNWQTIPPGMVITDE 152 + H GGY ++AD+T V A G + I + +N + + IP M Sbjct: 127 IASHVGGYDEWKADITEAVEAFRRTPLCRERFGGKIPIAIRCDNSRDTEMIPSDM----- 181 Query: 153 NGKKKQSYFHDFFNYAGIHRSVMLYTTPNTWVDDITVVTHVAQDCNHASVDWQVVANG-- 210 DF Y G++R V L TP + I + + S+ + G Sbjct: 182 ---------SDFNLYGGLYRYVNLVYTPAVHFEQIRIEATTDEKGKQGSISIDIAFGGLS 232 Query: 211 ------------DVSVELRDADQQVVATGQGTSGTLQVVNPHLWQPGEGYLYELCVTAKS 258 S E ++ + + +S + + P LW P LY Sbjct: 233 GKEKKAKEFSLRVFSPEGKEVNSISSELTEISSYQISLKRPQLWSPHSPALYTCVAELID 292 Query: 259 QTECDIYPLRVGIRSVAVKGE-QFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHAL 317 + G R + + F +N + G RHED G +M + Sbjct: 293 NGDTLRTTQHFGFRHFRFEEKGPFYLNGERLLLRGTHRHEDHAGVGAALTEEMMRTEMQQ 352 Query: 318 MDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSE 377 + +GAN R HY + +L DE G++V +E I + G E Y Sbjct: 353 IKEMGANFIRLGHYQQSGIILRLCDELGLLVWEE-----------IPWCRGGLGGESYKN 401 Query: 378 EAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPD-------TRPQGAREYFAPLAE 430 +A + + +I + +NHPSV++W + NE D R + L + Sbjct: 402 QA---------RRMLTNMIEQHRNHPSVILWGLGNENDWPGDFQTFEKDSIRAFMGELHD 452 Query: 431 ATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQS----GDLETAEKVLE 486 +LDPTR FC D+ DV + GWY + ++ETA Sbjct: 453 LAHRLDPTRSTAIRRCEFC-------KDIVDVYSPTIWAGWYGRRFRNYREMETA----- 500 Query: 487 KELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDM-------------------WSEEYQC 527 + A LH E+G D+ AG H WSE Y Sbjct: 501 -GINATTRFLH-----AEWGGDSHAGRHMEVNKETGRKGIDNFDIEAADRNGDWSESYII 554 Query: 528 AWLDMYHRVFDRVSAVVGEQVWNFADFATSQGILRVGG-----NKKGIFTRDRKPKSAAF 582 D + + + + + G W F DF+T LR N+KG+ RD PK + + Sbjct: 555 RLFDWHLKEQETMPRLTGSLFWTFKDFSTP---LRPDNPIPYVNQKGVVQRDGTPKESYY 611 Query: 583 LLQKRWT 589 + Q W+ Sbjct: 612 VFQSYWS 618 >5EUV-A nrPDB Length = 731 Score = 123 bits (308), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 126/450 (28%), Positives = 192/450 (42%), Gaps = 72/450 (16%) Query: 36 ESALQESRAIAVPGSFNDQFADADIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYG 95 E+ A+ +P S+ D+ + Y YQR + W G+R+ LRFD Sbjct: 27 ETVTLPHNAVDLPLSYFDETS------YQRAFTYQRVIAWDDAWQGRRVQLRFDGAMADN 80 Query: 96 KVWVNNQEVMEHQGGYTPFEADVTPYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGK 155 VWVN +V+ H GYTPF AD+T ++ G ++ +TV ++ N P G I Sbjct: 81 VVWVNGVQVVAHPDGYTPFVADLTDHLRPGDNL-VTVRIDGSENPAIPPFGAQI------ 133 Query: 156 KKQSYFHDFFNYAGIHRSVMLYTTPNTWVDDITVVTHVA-QDCNHASVDWQVVANGDVSV 214 D+ YAGI+R V L P + + ++T A D + +V A G V Sbjct: 134 -------DYLTYAGIYRDVWLMVLPERHLTNARILTPDALSDAKTVVIRPEVTAPGPVRA 186 Query: 215 ELRDADQQVVAT-GQGTSGTLQVVNPHLWQPGEGYLYELCVTAKSQTECDIYPLRVGIRS 273 L D D+++ AT G+G + LW LY + +T D+ R G R+ Sbjct: 187 RLLDGDREIAATEGEGELTLAGLTGLSLWSTDNPQLYTVELTLPDSG--DVTTHRFGFRT 244 Query: 274 VAVKGEQFLINHKPFYFTGFGRHED-------ADLRGKGFDNVLMVHDHALMDWIGANSY 326 + FL+N +P G RH+ A + D ++ HD + N Sbjct: 245 AEWTPQGFLLNGQPMKLRGLNRHQSWAHQGYAAGRHAQERDAEIVRHD------LCCNMV 298 Query: 327 RTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQ 386 RTSHYP + LD DE G++V +E IG +A + + +V+ Sbjct: 299 RTSHYPQSTWFLDRCDEIGLLVFEEIPGWQH-----IGDQA-------WQDRSVDN---- 342 Query: 387 AHLQAIKELIARDKNHPSVVMWS--IANEPDTRPQGAREYFAPLAEATRKLDPTRPITCV 444 ++ +I RD NHPS+V+W I PD +++ R+LDPTR I V Sbjct: 343 -----VRAMITRDWNHPSIVIWGVRINESPDN-----HDFYVRTNALARELDPTRAIGGV 392 Query: 445 NV-----MFCDAHT--DTISDLFDVLCLNR 467 M D +T D I D ++ +NR Sbjct: 393 RCITDSEMLEDVYTMNDFILDESELPLINR 422 >6B6L-A nrPDB Length = 776 Score = 122 bits (306), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 137/477 (28%), Positives = 197/477 (41%), Gaps = 82/477 (17%) Query: 31 DQRWWESALQESRAIA-VPGSFNDQFADADIR-----NYAGNVWYQREVFIPKGWAGQRI 84 D +W + L +I +PG+ + ADA G WY++ +I G+ I Sbjct: 31 DSQWRQINLPHDWSIEDIPGTNSPFTADAATEVAGGFTVGGTGWYRKHFYIDAAEKGKCI 90 Query: 85 VLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIAGKSVRITVCVNNELNWQTIP 144 + FD + +WVN++ V H GYT FE D+T YV G I V V NE Sbjct: 91 AVSFDGIYMNADIWVNDRHVANHVYGYTAFELDITDYVRFGAENLIAVRVKNE------- 143 Query: 145 PGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTP----NTWVDDITVVTHVAQDCNHA 200 GM ++ +GI+R L T TW T VT + A Sbjct: 144 -GMNCR-------------WYTGSGIYRHTFLKITNPLHFETWG---TFVTTPVATADKA 186 Query: 201 SVDWQ-VVAN-----GDVSVELR--DADQQVVATGQG-----------TSGTLQVVNPHL 241 V Q V+AN G V +E R D + VA + L+V+ P L Sbjct: 187 EVHVQSVLANTEKVTGKVILETRIVDKNNHTVARKEQLVTLDNKEKTEVGHALEVLAPQL 246 Query: 242 WQPGEGYLYELC-VTAKSQTECDIYPLRVGIRSVAVKGEQ-FLINHKPFYFTGFGRHEDA 299 W YLY++ + D + +GIR++A E F +N K G H D Sbjct: 247 WSIDNPYLYQVVNRLLQDDKVIDEEYISIGIRNIAFSAENGFQLNGKSMKLKGGCIHHDN 306 Query: 300 DLRG-KGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFN 358 L G K FD L+ G N+ R SH P + +L+ D G++VIDE F+ Sbjct: 307 GLLGAKAFDRA-EERKIELLKAAGFNALRLSHNPPSIALLNACDRLGMLVIDE----AFD 361 Query: 359 L-SLG-IGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDT 416 + G ++ +L+ E+ + ++ARD+NHPSV+MWSI NE Sbjct: 362 MWRYGHYQYDYAQYFDKLWKED-------------LHSMVARDRNHPSVIMWSIGNEIKN 408 Query: 417 RPQGA-REYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVL----CLNRY 468 + + L + LD TRP+T DA D ++ L DV CLNRY Sbjct: 409 KETAEIVDICRELTGFVKTLDTTRPVTAGVNSIVDATDDFLAPL-DVCGYNYCLNRY 464 >3DEC-A nrPDB Length = 1000 Score = 119 bits (299), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 129/505 (25%), Positives = 198/505 (39%), Gaps = 91/505 (18%) Query: 69 YQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIAGKSV 128 Y+R +P GW G+R+VL + V + VWVN + + +QG T E D+T + G++ Sbjct: 126 YRRTFKVPAGWEGRRVVLCCEGVISFYYVWVNGEFLGYNQGSKTAAEWDITDKLTDGENT 185 Query: 129 RITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNTWVDDIT 188 I + V W + G + D + +GI R V LY+TP ++ D Sbjct: 186 -IALEV---YRWSS---GAYLE----------CQDMWRLSGIERDVYLYSTPEQYIADYK 228 Query: 189 VVT-----HVAQDCNHASVDWQVVANGDVSV--ELRDADQQVVATGQGT-----SGTLQV 236 V + H + V A+G S+ L+DA + V G SG L V Sbjct: 229 VTSLLEKEHYKEGIFELEVAVGGTASGTSSIAYTLKDASDKTVLEGSRKLESHGSGNLIV 288 Query: 237 VNPH------LWQPGEGYLYELCVTAKSQ--TECDIYPLRVGIRSVAVKGEQFLINHKPF 288 + W LY L + K +I +VG R+ +K +F IN P Sbjct: 289 FDEQRLPDVRRWNAEHPELYTLLLELKDAGGKVTEITGTKVGFRTSEIKNGRFCINGVPV 348 Query: 289 YFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVV 348 G RHE + L G+ LM D LM N+ R SHYP D +G+ V Sbjct: 349 LVKGVNRHEHSQL-GRTVSKELMEQDIRLMKQHNINTVRNSHYPAHPYWYQLCDRYGLYV 407 Query: 349 IDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMW 408 IDE + G P L A + AH+ + + R KNHPSVV+W Sbjct: 408 IDEANIESHGMGYG--------PASL----AKDSTWLPAHIDRTRRMYERSKNHPSVVIW 455 Query: 409 SIANEPDTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRY 468 S+ NE R Y + + ++ RP+ + +TD ++ + + R Sbjct: 456 SLGNEAGNGINFERTY-----DWLKSVEKNRPVQYERAEE-NYNTDIYCRMYRSVDVIRN 509 Query: 469 YGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCA 528 Y V+ K+ +++P I+ EY LH+M C Sbjct: 510 Y--------------VVRKD-------IYRPFILCEY-------LHAMGN-------SCG 534 Query: 529 WLDMYHRVFDRVSAVVGEQVWNFAD 553 + Y VF+ G +W++ D Sbjct: 535 GMKEYWEVFENEPMAQGGCIWDWVD 559 >3GM8-A nrPDB Length = 801 Score = 108 bits (271), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 100/393 (25%), Positives = 163/393 (41%), Gaps = 49/393 (12%) Query: 64 AGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVI 123 AG WY++ IP W +++ + F+ V +VW+N + + GY F D+TPY+ Sbjct: 65 AGISWYRKTFTIPSKWKNKKVQILFEGVYLNSEVWINGHWLGKRPNGYISFVYDLTPYLQ 124 Query: 124 AGKSVRITVCVNNEL----NWQT-----IPPGMVITDENGKKKQSYFHDFFNYAGIH-RS 173 GK+ +I V V++ W T P +++++ Y+GIH RS Sbjct: 125 EGKN-QIAVKVDHSKALTGRWYTGSGIYRPVYLLVSNPT----------HIPYSGIHFRS 173 Query: 174 VMLYTTPNTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGT 233 + T+ I + T + + + NG ++ D +++ + + Sbjct: 174 KLQNKQSATYTLSIEIETQEKKPIKVKT--YLQAPNGSIA----DTSEKIFVSSADSLCF 227 Query: 234 L--QVVNPHLWQPGEGYLYEL-CVTAKSQTECDIYPLRVGIRSVAVKG-EQFLINHKPFY 289 L + P LW P +Y L C + D L VG R + FL+N K Sbjct: 228 LSGSIRKPLLWSPDSPNVYTLICQLTRDNKILDECRLPVGFRQLEFNPVSGFLLNGKSLK 287 Query: 290 FTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVI 349 G H G + L+ + L+ +G N+ RTSH P++ + D GI+V+ Sbjct: 288 IKGVCDHHTVGAVGAAVPDDLLHYRLKLLKDMGCNAIRTSHNPFSPAFYNLCDTMGIMVL 347 Query: 350 DETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWS 409 +E G + N+PK E Q + + + I RD+NHPS++MWS Sbjct: 348 NE------------GLDGWNQPKAADDYGNYFDEWWQ---KDMTDFIKRDRNHPSIIMWS 392 Query: 410 IANEPDTRPQGAREYFAPLAEATRKLDPTRPIT 442 I NE E L +LDP RP+T Sbjct: 393 IGNEVTG---ATPEIQHNLVSLFHQLDPDRPVT 422 >6ETZ-A nrPDB Length = 989 Score = 102 bits (254), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 123/530 (23%), Positives = 206/530 (38%), Gaps = 101/530 (19%) Query: 85 VLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIAGK-SVRITVCVNNELNWQTI 143 +LRFD + G VW+N E+ +G E DV+ + G+ ++ + V + ++ Sbjct: 125 LLRFDGIESAGTVWLNGVELGTTRGSRLAHEFDVSGILEQGENTLAVRVAQFSAASY--- 181 Query: 144 PPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNTWVDDITVVTHVAQDCNHASVD 203 + D+ D + GI R V L P +DD+ V HA D Sbjct: 182 -----VEDQ----------DMWWLPGIFRDVTLQARPAAGIDDVFV---------HAGYD 217 Query: 204 WQVVANGDVSVELRDADQQVVAT----------GQGTSGTLQVVNPHLWQPGEGYLYELC 253 + G + VE Q + A GT + V P W LYE Sbjct: 218 -HITGEGILKVEASRGGQAIDAVVRVPELALELAAGTEVRVPAVEP--WSAEVPKLYEAA 274 Query: 254 VTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVH 313 V+A ++ L++G RS+A++ QF +N + G RHE G+ ++ Sbjct: 275 VSAAGESVA----LQIGFRSIAIEDAQFKVNGRRILLRGVNRHEHHPRLGRVVPRDVVEA 330 Query: 314 DHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKE 373 + LM N+ RTSHYP + L AD+ G V+ E +L GFE+ + Sbjct: 331 ELRLMKQHNINAIRTSHYPPHPQFLALADQLGFYVVLEC-----DLETH-GFESAGWAQN 384 Query: 374 LYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQGAREYFAPLAEATR 433 + + + A + ++ + RDKNH SVVMWS+ NE G A ++ T+ Sbjct: 385 PSDDP----QWEDALVDRMRRTVERDKNHASVVMWSLGNE-----AGTGRNLAAMSRWTK 435 Query: 434 KLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQ 493 DP+RPI + H D S ++ G ++ + A + + Sbjct: 436 DRDPSRPIHYEG-DWSSEHVDVYSRMYASQAETALIGQGIEPALNDAALDARRRAM---- 490 Query: 494 EKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFAD 553 P ++ EY +H+M + Y +F++ ++G VW + + Sbjct: 491 -----PFVLCEY-------VHAMGNG-------PGGMSEYQALFEKYPRLMGGFVWEWLE 531 Query: 554 ----FATSQGILRVG-----------GN--KKGIFTRDRKPKSAAFLLQK 586 +T+ G+ G GN G+ DR+P+ +K Sbjct: 532 HGITVSTADGVDHYGYGGDFGEEVHDGNFVTDGLVDADRRPRPGLLDFKK 581 >4YPJ-A nrPDB Length = 810 Score = 101 bits (252), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 111/452 (24%), Positives = 186/452 (41%), Gaps = 82/452 (18%) Query: 68 WYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIA-GK 126 WY++ IP+ G+RI L FD V ++N + + + GY F D++ + G+ Sbjct: 73 WYRKTFTIPESMKGKRISLDFDGVYMNSTTYLNGEVLGTYPFGYNAFSYDISDKLYKDGR 132 Query: 127 SVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVML---------- 176 + + V VNN T P +++ +GI+R+V L Sbjct: 133 ANVLVVKVNN-----TQPSSR----------------WYSGSGIYRNVYLTVTDPIHVAR 171 Query: 177 ----YTTPNTWVD------DITVVTHVAQDCNHA---SVDWQVVANGDVSVELRDADQQV 223 TTPN D+ + T ++ D A + + +V+ + +++ Sbjct: 172 YGTFVTTPNLEKSIKEDRADVNIKTKISNDAAEAKQVKIKSTIYDGAGNTVQTVETEEKT 231 Query: 224 VATGQGTSGTLQVV--NPHLWQPGEGYLYELC--VTAKSQTECDIYPLRVGIRSVAV-KG 278 A G T V P LW + Y Y L V QT D Y + G+R + Sbjct: 232 AAAGTVTPFEQNTVIKQPKLWSIDKPYRYNLVTEVIVGGQT-VDTYETKFGVRYFKFDEN 290 Query: 279 EQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEML 338 E F +N + G H D G + + +M +G N+ R +H P + E+L Sbjct: 291 EGFSLNGEYMKLHGVSMHHDLGALGAATNARGVERQMQIMKDMGVNAIRVTHNPASPELL 350 Query: 339 DWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQ-AIKELIA 397 + A++ G+ +I+E F++ + K+ Y G A + IKE++ Sbjct: 351 EAANKLGLFIIEE------------AFDSWAQSKKPYDY----GRFFNAWAEHDIKEMVD 394 Query: 398 RDKNHPSVVMWSIANEP-DTRPQGAREYFAPLAEATRKLDPTRPITC---------VNVM 447 R KN P+++MWSI NE DT E L +++D TRP T VNV Sbjct: 395 RGKNEPAIIMWSIGNEIYDTTNAAGVETARNLVGWVKEIDTTRPTTIGEDKTRGDKVNVT 454 Query: 448 FCDAHTDTISDLFDVLCL----NRYYGWYVQS 475 +++ I ++ DV+ L N Y G++ Q+ Sbjct: 455 PINSYIKEIFNIVDVVGLNYSENNYDGYHKQN 486 >5DMY-A nrPDB Length = 904 Score = 98.6 bits (244), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 104/416 (25%), Positives = 160/416 (38%), Gaps = 59/416 (14%) Query: 64 AGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVI 123 G WY++ I + AG+RI + FD V VW N ++ H GY+PF D+T Sbjct: 93 GGTGWYRKSFTIDRDLAGKRIAINFDGVYMNATVWFNGVKLGTHPYGYSPFSFDLTGNAK 152 Query: 124 AGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNTW 183 G I V V N L P +++ +GI+R V L T Sbjct: 153 FGGENTIVVKVENRL-----PSSR----------------WYSGSGIYRDVTLTVTDGVH 191 Query: 184 VDD-------------------ITVVTHVAQDCNHA---SVDWQVVANG---DVSVELRD 218 V + + + T VA D A ++ V G D ++ Sbjct: 192 VGNNGVAIKTPSLATQNGGNVTMNLTTKVANDTEAAANITLKQTVFPKGGKTDAAIGTVT 251 Query: 219 ADQQVVATGQGT--SGTLQVVNPHLWQPGEGYLYELCVTA-KSQTECDIYPLRVGIRSVA 275 + +A G + T+ +P LW LY + T D Y G R Sbjct: 252 TASKSIAAGASADVTSTITAASPKLWSIKNPNLYTVRTEVLNGDTVLDTYDTEYGFRWTG 311 Query: 276 VKGEQ-FLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYA 334 F +N + G H D G + + ++ +G NS RT+H P A Sbjct: 312 FDATSGFSLNGEKVKLKGVSMHHDQGSLGAVANRRAIERQVEILQKMGVNSIRTTHNPAA 371 Query: 335 EEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNK--PKELYSEEAVNGETQQAHLQA- 391 + ++D +E G++V++E + +N S E K + + + AV G + Sbjct: 372 KALIDVCNEKGVLVVEEVFDM-WNRSKNGNTEDYGKWFGQTIAGDNAVLGGDKDETWAKF 430 Query: 392 -IKELIARDKNHPSVVMWSIANEPDTRPQGAREYF----APLAEATRKLDPTRPIT 442 + I RD+N PSV+MWS+ NE G+ F A L T+ D TRP+T Sbjct: 431 DLTSTINRDRNAPSVIMWSLGNEMMEGISGSVSDFPATSAKLVAWTKAADSTRPMT 486 >5T9G-A nrPDB Length = 846 Score = 79.0 bits (193), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 108/476 (22%), Positives = 181/476 (38%), Gaps = 120/476 (25%) Query: 68 WYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYV-IAGK 126 WY + P + ++ + FD V + + W+N +++ H GY+PF D++ Y+ G+ Sbjct: 88 WYSKTFDTPDNFVDKKCYIVFDGVYNNSEYWINGRKLGFHPYGYSPFFYDISDYLNPKGQ 147 Query: 127 SVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHD--FFNYAGIHRSVMLYTTPNTWV 184 RI+V ++ S + D ++ +GI+R L T + Sbjct: 148 ENRISVRID----------------------HSRYADSRWYTGSGIYRETQLIFTDKLHI 185 Query: 185 DDI-TVVTHVAQDCNHASVDWQVVANGDVSV----ELRDA--DQQVVATGQGTSGTL--- 234 T VT A+V+ +V D S E+R + D + G+ + L Sbjct: 186 PVWGTFVTTPVVSSERATVNIEVRVKNDYSGPRAGEVRTSYFDSKNKKVGEKLTSFLIEA 245 Query: 235 ----------QVVNPHLWQPGEGYLYELCVTAKSQ-----TECDIYPLRVGIRSVAVKGE 279 ++ NP LW +Y AKS+ D GIRS+ + Sbjct: 246 GKEMKINQSVEISNPSLWDVDSPSMY----LAKSEILVDGNVVDTKETPFGIRSIKFDAK 301 Query: 280 Q-FLINHKPFYFTGFGRHEDADLRGKGF-DNVLMVHDHALMDWIGANSYRTSHYPYAEEM 337 + F +N K G H DA + G ++V L D G N+ R SH P A+ Sbjct: 302 KGFFLNGKNMKIKGVCLHHDASMIGAALVEDVWRRRLQTLKDG-GCNAIRLSHNPGADAF 360 Query: 338 LDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKEL---YSEEAVNGET-------QQA 387 L+ DE G +V +E F+ + PK+ E++++ T Q+ Sbjct: 361 LELCDEMGFLVQEEF------------FDEWDYPKDKRLNMDEQSIDYITRGYCEYFQEW 408 Query: 388 HLQAIKELIARDKNHPSVVMWSIANEPDTRPQGARE------------YF---------- 425 + +K ++ R +NHP + WSI NE + +G +E YF Sbjct: 409 AERDLKNVMLRSRNHPCIFQWSIGNEIEWTYKGCKESTGFFSADAGGGYFWNQPPYSTQR 468 Query: 426 -------------------APLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDV 462 LA TR++D TRP+T ++ ++ D DV Sbjct: 469 IREEWAKQPKQTYDIGRTAKKLAAWTREMDTTRPVTANCILPSISYETGYIDALDV 524 >4CUC-A nrPDB Length = 849 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 107/450 (23%), Positives = 171/450 (38%), Gaps = 82/450 (18%) Query: 64 AGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVI 123 G WY++ + + + + L FD V +V+VN Q V + GY F D+T Y+ Sbjct: 73 GGEAWYRKTFKLDEKDLKKNVRLTFDGVYMDSQVYVNGQLVGHYPNGYNQFSYDITKYL- 131 Query: 124 AGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNTW 183 K R V + +N Q P +++ +GI+R V L T Sbjct: 132 -QKDGRENVIAVHAVNKQ--PSSR----------------WYSGSGIYRDVTLQVTDKVH 172 Query: 184 VDD--ITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVAT-------GQGTSG-- 232 V+ T++T ++ H V+ V + V D D ++VA G +G Sbjct: 173 VEKNGTTILTPKLEEQQHGKVETHVTSK---IVNTDDKDHELVAEYQIVERGGHAVTGLV 229 Query: 233 -----------------TLQVVNPHLW-----QPGEGYLYELCVTAKSQTE-CDIYPLRV 269 L+V P LW +P LYEL + D Sbjct: 230 RTASRTLKAHESTSLDAILEVERPKLWTVLNDKPA---LYELITRVYRDGQLVDAKKDLF 286 Query: 270 GIRSVA-VKGEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRT 328 G R E F +N + F G H D G + M +G NS RT Sbjct: 287 GYRYYHWTPNEGFSLNGERIKFHGVSLHHDHGALGAEENYKAEYRRLKQMKEMGVNSIRT 346 Query: 329 SHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKE---LYSEEAVNGETQ 385 +H P +E+ L A E G++V +E F+ G G KP + + ++A + E + Sbjct: 347 THNPASEQTLQIAAELGLLVQEE----AFDTWYG-----GKKPYDYGRFFEKDATHPEAR 397 Query: 386 QAHLQA---IKELIARDKNHPSVVMWSIANEPDTRPQGAREY--FAPLAEATRKLDPTRP 440 + + ++ ++ R KN+P++ MWSI NE A L + + +D TR Sbjct: 398 KGEKWSDFDLRTMVERGKNNPAIFMWSIGNEIGEANGDAHSLATVKRLVKVIKDVDKTRY 457 Query: 441 ITCVNVMF----CDAHTDTISDLFDVLCLN 466 +T F + I+D D + N Sbjct: 458 VTMGADKFRFGNGSGGHEKIADELDAVGFN 487 >5N6U-A nrPDB Length = 836 Score = 37.4 bits (85), Expect = 0.017, Method: Compositional matrix adjust. Identities = 111/515 (21%), Positives = 186/515 (36%), Gaps = 134/515 (26%) Query: 9 TREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI-------R 61 + EI KLDG W F + D++W R VPG + + + Sbjct: 23 SMEILKLDGEWEFKAVK-----DKKW--------RKAKVPGCVHLDLMENGLIPDPFVGE 69 Query: 62 NYAGNVWYQRE--VFIPKGWAGQR------IVLRFDAVTHYGKVWVNNQEVMEHQGGYTP 113 N W ++E ++ K G+ I L F+ + + ++++N +++ E + Sbjct: 70 NELEVQWVEKEDWIYRKKFQVGKEFLKYSSIYLEFEGIDTFSEIYLNGKKIGETDNMFIA 129 Query: 114 FEADVTPYVIAGKSVRITVCVNNELNWQTIPPGMVITDEN-----------------GKK 156 +E +V ++ G+ NEL + P V+ + G+K Sbjct: 130 WEFNVKDLLVEGE---------NELEVRLFSPSKVLEERAKNYPYKLHGGDYSPRVFGRK 180 Query: 157 KQSYF----HDFFNYAGIHRSVMLYTTPNTWVDDITV-VTHVAQDCN-HASVDWQVVANG 210 Q F +GI +SV L + D+ V V + ++ + +D ++ + Sbjct: 181 AQYSFGWDWGPRLATSGIWKSVKLKGWNKARLLDVWVPVRSLGENAQINIELDIELQESI 240 Query: 211 DVSVELRDADQQVVATGQ----------GTSGTLQVVNPHLWQP---GEGYLY--ELCVT 255 V V R + ++ V + L + NP LW P GE LY +L + Sbjct: 241 PVDVAFRISHKKPVLEQRLRFTLPEGRVFLKIPLTIKNPKLWFPRGYGEQNLYTLQLVLL 300 Query: 256 AKSQTECDIYPLRVGIRSVAV------KGEQFL--INHKPFYFTG---------FGRHED 298 + D R GIR V + KGE F+ IN+ P + G R ++ Sbjct: 301 DEKGEVLDKVEERFGIRKVELFTQEDNKGESFVFKINNIPVFAKGANWIPADSFLPRIKE 360 Query: 299 ADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEE--MLDWADEHGIVVIDETAAVG 356 D R +L++ G N R E + DE GI+V + Sbjct: 361 EDYR------LLLIRAKE----AGVNMLRVWGGGIYENDIFYELCDELGIMVWQDFM--- 407 Query: 357 FNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPD- 415 F P + E +N ++A +I R +NHPS+V+W N Sbjct: 408 --------FACAEYPDD---ENFLNDVQKEAEF-----VIKRLRNHPSIVLWCGNNCNHW 451 Query: 416 ---TRPQGAREYF-------APLAEATRKLDPTRP 440 + G RE F L + +LD TRP Sbjct: 452 GYYAKWWGEREKFWGEEIYSRVLPDVCARLDLTRP 486 >5BX9-A nrPDB Length = 416 Score = 37.4 bits (85), Expect = 0.018, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 38/79 (48%), Gaps = 9/79 (11%) Query: 393 KELIARDKNHPSVVMWSIANEPDT----RPQGAREYFAPLAEAT----RKLDPTRPITCV 444 + + + +PSV W + NEP+ RP+ E +A L +A+ R +DP +P+ Sbjct: 119 RRMAMLSQRYPSVAAWQVWNEPNLIGFWRPKADPEGYAKLLQASTIALRMVDPEKPVVSA 178 Query: 445 NVMFCDAHTDTISDLFDVL 463 + F D + +FD L Sbjct: 179 GMAFFSEMPDGRT-MFDAL 196 >3PZU-A nrPDB Length = 327 Score = 35.8 bits (81), Expect = 0.053, Method: Compositional matrix adjust. Identities = 52/211 (24%), Positives = 82/211 (38%), Gaps = 31/211 (14%) Query: 383 ETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQGAREYFAPLAE----ATRKLDPT 438 + ++ + KE+ + N P+V+ + IANEP+ R+ P AE RK DP Sbjct: 135 QNKEKAKEFFKEMSSLYGNTPNVI-YEIANEPNGDVNWKRD-IKPYAEEVISVIRKNDPD 192 Query: 439 RPITCVNVMFC----DAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQE 494 I + DA D + D + L+ Y G + Q + A L K Sbjct: 193 NIIIVGTGTWSQDVNDAADDQLKDANVMYALHFYAGTHGQF-LRDKANYALSK------- 244 Query: 495 KLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADF 554 PI +TE+G +G ++ D E WL + D S + WN +D Sbjct: 245 --GAPIFVTEWGTSDASGNGGVFLDQSRE-----WL----KYLD--SKTISWVNWNLSDK 291 Query: 555 ATSQGILRVGGNKKGIFTRDRKPKSAAFLLQ 585 S L+ G +K G + S F+ + Sbjct: 292 QESSSALKPGASKTGGWRLSDLSASGTFVRE 322 >3WFL-A nrPDB Length = 342 Score = 34.7 bits (78), Expect = 0.14, Method: Compositional matrix adjust. Identities = 16/47 (34%), Positives = 26/47 (55%), Gaps = 4/47 (8%) Query: 368 GNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEP 414 G Y++EA +Q A+ IK +++R + P+V W +ANEP Sbjct: 127 GGSTTSWYTDEA----SQAAYRNYIKTVVSRYIDSPAVFAWELANEP 169 >5WH8-A nrPDB Length = 323 Score = 34.3 bits (77), Expect = 0.15, Method: Compositional matrix adjust. Identities = 47/181 (25%), Positives = 72/181 (39%), Gaps = 35/181 (19%) Query: 398 RDKNHPSVVMWSIANEP---DTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCD---- 450 +D H V++ I NEP D + +EY + RK DP + I C + Sbjct: 137 KDDKH---VLYEICNEPNGFDVKWADVKEYAEAVIPVIRKNDPDKIIICGTPTWSQDVDL 193 Query: 451 AHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTL 510 A D +S + L+ Y G + Q L +V + LA + +TE+G Sbjct: 194 AAQDPLSYDNVMYTLHFYSGTHTQY--LRDKAQVAINKGLA--------LFVTEFGTTQA 243 Query: 511 AGLHSMYTDMWSEEYQC-AWLD-MYHRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKK 568 +G +Y D +C W+D M R V+ W+FAD S L+ G + Sbjct: 244 SGDGGVYFD------ECNTWMDWMDARKISWVN-------WSFADKPESSAALKPGASNS 290 Query: 569 G 569 G Sbjct: 291 G 291 >3ZIZ-A nrPDB Length = 382 Score = 33.9 bits (76), Expect = 0.20, Method: Compositional matrix adjust. Identities = 17/66 (25%), Positives = 31/66 (46%), Gaps = 3/66 (4%) Query: 380 VNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQGAREYF---APLAEATRKLD 436 N Q+ + + I+ +++R N P++ W +ANEP + F +++ R LD Sbjct: 147 TNARAQEQYKRYIQAVVSRYVNSPAIFAWELANEPRCKGCNTNVIFNWATQISDYIRSLD 206 Query: 437 PTRPIT 442 IT Sbjct: 207 KDHLIT 212 >1UUQ-A nrPDB Length = 440 Score = 33.1 bits (74), Expect = 0.36, Method: Compositional matrix adjust. Identities = 35/168 (20%), Positives = 70/168 (41%), Gaps = 36/168 (21%) Query: 383 ETQQAHLQAIKELIARDK--------NHPSVVMWSIANEPDTRPQGAR----------EY 424 + QQ + + ++++I R + +++ W +ANEP RP ++ ++ Sbjct: 177 KAQQEYRKTLEKIITRVNSINGKAYVDDATIMSWQLANEP--RPGNSQTTAEEKQIYIDW 234 Query: 425 FAPLAEATRKLDPTRPITC--------VNVM--FCDAHTDTISDLFDVLCLNRYYGWYVQ 474 A + LD ++ VN M F DAH D R + W+ + Sbjct: 235 VHAAAAYIKTLDAHHLVSSGSEGEMGSVNDMQVFIDAHATPDIDYLTYHMWIRNWSWFDK 294 Query: 475 SGDLETAEKVLEKEL------LAWQEKLHQPIIITEYGVDTLAGLHSM 516 + ET EK + ++L++P+++ E+G+D G ++M Sbjct: 295 TKPAETWPSAWEKAQNYMRAHIDVAKQLNKPLVLEEFGLDRDMGSYAM 342 >1HRI-3 nrPDB Length = 236 Score = 32.7 bits (73), Expect = 0.45, Method: Compositional matrix adjust. Identities = 18/58 (31%), Positives = 27/58 (46%), Gaps = 4/58 (6%) Query: 35 WESALQESRAIAVPGSFNDQF--ADADIRNYAG--NVWYQREVFIPKGWAGQRIVLRF 88 W+ LQ + + +P + QF D D AG + WYQ + +P GQ +L F Sbjct: 153 WDIGLQSTIVMTIPWTSGVQFRYTDPDTYTSAGFLSCWYQTSLILPPETTGQVYLLSF 210 >2X5I-C nrPDB Length = 238 Score = 32.0 bits (71), Expect = 0.90, Method: Compositional matrix adjust. Identities = 18/58 (31%), Positives = 27/58 (46%), Gaps = 4/58 (6%) Query: 35 WESALQESRAIAVP--GSFNDQFADADIRNYAGNV--WYQREVFIPKGWAGQRIVLRF 88 W+ LQ S + +P + + D AGNV WYQ + +P G + +VL F Sbjct: 156 WDIGLQSSCVLCIPWISQTHYRLVQQDEYTSAGNVTCWYQTGIVVPPGTPNKCVVLCF 213 >3WH9-A nrPDB Length = 345 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 14/48 (29%), Positives = 24/48 (50%), Gaps = 4/48 (8%) Query: 367 AGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEP 414 G+ + Y+ + + Q A+ IK ++ R N +V W +ANEP Sbjct: 126 GGSGETDFYTSDTM----QSAYQTYIKTVVERYSNSSAVFAWELANEP 169 >5A94-A nrPDB Length = 365 Score = 29.6 bits (65), Expect = 4.1, Method: Compositional matrix adjust. Identities = 36/172 (20%), Positives = 71/172 (41%), Gaps = 35/172 (20%) Query: 265 YPLRVGIRS------VAVKGEQFLINH-KPFYFTGFGRHEDADLRGKGFDNVLMVHDHAL 317 YP + ++S ++VKG +F+ + K F F G + L + + + A Sbjct: 36 YPSQFDVKSLKTQSFISVKGNKFIDDKGKTFTFRGVNIADTGKLLSRNQWQKSLFEELA- 94 Query: 318 MDWIGANSYRTSHYP-------------YAEEMLDWADEHGIVVIDETAAVGFNLSLGIG 364 +W G N+ R +P + +E + WA++ GI +I + ++G+ Sbjct: 95 NNW-GVNTIRLPIHPVSWRKLGPDVYLGHIDEAVRWANDLGIYLILDWHSIGY------- 146 Query: 365 FEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDT 416 P E Y + ++ + + R +N P+V ++ + NEP T Sbjct: 147 -----LPTEQYQHPMYDTTIKETR-DFWRRITFRYQNVPTVAVYELFNEPTT 192 >3RTJ-B nrPDB Length = 262 Score = 29.6 bits (65), Expect = 4.3, Method: Compositional matrix adjust. Identities = 23/81 (28%), Positives = 34/81 (41%), Gaps = 21/81 (25%) Query: 196 DCNHASVD---WQVVANGDVSVELRDADQQVVATGQGTSGTLQVVNPHLWQPGEGY---- 248 DCN A+ D WQ+ NG + + V+A G SGT V +++ +G+ Sbjct: 79 DCNTAATDATRWQIWDNGTI---INPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTN 135 Query: 249 -----------LYELCVTAKS 258 LY LC+ A S Sbjct: 136 NTQPFVTTIVGLYGLCLQANS 156 >1VFF-A nrPDB Length = 423 Score = 28.9 bits (63), Expect = 6.2, Method: Compositional matrix adjust. Identities = 24/88 (27%), Positives = 40/88 (45%), Gaps = 9/88 (10%) Query: 498 QPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFAD-FAT 556 +P+ ITE G+ TL D W E+ L H+ + V G W+F D + Sbjct: 318 RPLYITENGIATL-------DDEWRVEFIIQHLQYVHKAIEDGLDVRGYFYWSFMDNYEW 370 Query: 557 SQGI-LRVGGNKKGIFTRDRKPKSAAFL 583 +G R G + T +R+P+ +A++ Sbjct: 371 KEGFGPRFGLVEVDYQTFERRPRKSAYV 398 >4XZW-A nrPDB Length = 313 Score = 28.9 bits (63), Expect = 7.3, Method: Compositional matrix adjust. Identities = 46/198 (23%), Positives = 72/198 (36%), Gaps = 28/198 (14%) Query: 396 IARDKNHPSVVMWSIANEPD---TRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAH 452 +AR+ + V++ IANEP+ T + R Y + R +D I + Sbjct: 125 MAREYGNTPNVIYEIANEPNGDVTWEEKIRPYADEVIRTIRSIDRDNLIIVGTGTWSQDV 184 Query: 453 TDTISDLFD----VLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVD 508 D SD + L+ Y G + Q + A L K PI +TE+G Sbjct: 185 DDVASDPLPYKNIMYALHFYAGTHGQFL-RDKANYALSK---------GTPIFVTEWGTS 234 Query: 509 TLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKK 568 +G ++ D E WL + D S + W+ D + LR G + Sbjct: 235 DASGDGGVFLDQSRE-----WL----KYLD--SKTISWVNWSLCDKNEASAALRPGADPH 283 Query: 569 GIFTRDRKPKSAAFLLQK 586 G + D S F+ K Sbjct: 284 GGWGDDHLSDSGRFIKAK 301 >3TTS-A nrPDB Length = 675 Score = 28.9 bits (63), Expect = 7.5, Method: Compositional matrix adjust. Identities = 10/20 (50%), Positives = 15/20 (75%) Query: 394 ELIARDKNHPSVVMWSIANE 413 +L R K+HP +VMW ++NE Sbjct: 131 KLAERYKDHPQIVMWHVSNE 150 >3WDP-P nrPDB Length = 473 Score = 28.5 bits (62), Expect = 8.2, Method: Compositional matrix adjust. Identities = 11/32 (34%), Positives = 19/32 (59%) Query: 295 RHEDADLRGKGFDNVLMVHDHALMDWIGANSY 326 + E ++R K ++ V ++H +DWIG N Y Sbjct: 277 KDEVEEIRKKDYEFVTILHSKGKLDWIGVNYY 308 >1BEV-3 nrPDB Length = 242 Score = 28.5 bits (62), Expect = 9.5, Method: Compositional matrix adjust. Identities = 18/54 (33%), Positives = 27/54 (50%), Gaps = 9/54 (16%) Query: 35 WESALQESRAIAVPGSFNDQF---ADADIRNY----AGNV--WYQREVFIPKGW 79 W+ LQ S + +P F ++ D+ NY AG+V WYQ + IP G+ Sbjct: 155 WDFGLQSSITLVIPWISASHFRGVSNDDVLNYQYYAAGHVTIWYQTNMVIPPGF 208 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3K4D-A nrPDB 851 0.0 6CXS-A nrPDB 720 0.0 5C70-A nrPDB 718 0.0 6ED2-A nrPDB 704 0.0 6BJW-A nrPDB 699 0.0 5Z19-A nrPDB 696 0.0 6ECA-A nrPDB 693 0.0 4JKL-A nrPDB 659 0.0 3HN3-A nrPDB 642 0.0 5Z1B-A nrPDB 630 0.0 6MVG-A nrPDB 529 e-150 6D8G-A nrPDB 518 e-147 6MVH-A nrPDB 512 e-145 6ED1-A nrPDB 504 e-143 3CMG-A nrPDB 493 e-139 6D89-C nrPDB 493 e-139 6NCZ-A nrPDB 488 e-138 6D8K-A nrPDB 482 e-136 6D1P-A nrPDB 475 e-134 6MVF-A nrPDB 475 e-134 6NCW-A nrPDB 458 e-129 6DXU-D nrPDB 451 e-127 3FN9-A nrPDB 449 e-126 5T99-A nrPDB 438 e-123 6B6L-A nrPDB 380 e-106 3GM8-A nrPDB 378 e-105 4YPJ-A nrPDB 375 e-104 5EUV-A nrPDB 372 e-103 5DMY-A nrPDB 371 e-103 3DEC-A nrPDB 364 e-101 6ETZ-A nrPDB 358 3e-99 5T9G-A nrPDB 352 3e-97 4CUC-A nrPDB 340 1e-93 Sequences not found previously or not previously below threshold: 5N6U-A nrPDB 158 5e-39 2WBK-A nrPDB 123 2e-28 6DDT-A nrPDB 117 2e-26 6BYC-A nrPDB 112 6e-25 4CVU-A nrPDB 70 3e-12 3ZIZ-A nrPDB 57 2e-08 3D3A-A nrPDB 50 2e-06 6EON-A nrPDB 48 1e-05 4AWE-A nrPDB 45 1e-04 4XZW-A nrPDB 44 2e-04 1UUQ-A nrPDB 44 2e-04 4NRS-A nrPDB 43 3e-04 1VFF-A nrPDB 42 7e-04 4UOQ-A nrPDB 41 0.001 1QNO-A nrPDB 41 0.002 3UG4-A nrPDB 40 0.003 3WF0-A nrPDB 39 0.007 2CKS-A nrPDB 39 0.009 3PZ9-A nrPDB 39 0.009 2RGL-A nrPDB 38 0.013 2Z1S-A nrPDB 38 0.014 3WH9-A nrPDB 38 0.014 1HRI-3 nrPDB 37 0.017 1RH9-A nrPDB 37 0.022 4XZB-A nrPDB 36 0.036 3WFL-A nrPDB 35 0.063 3VUP-A nrPDB 35 0.069 4UCF-A nrPDB 35 0.070 4JIE-A nrPDB 35 0.076 4ZEN-A nrPDB 35 0.093 4K68-A nrPDB 35 0.100 3PTM-A nrPDB 35 0.100 4QP0-A nrPDB 35 0.10 5A94-A nrPDB 35 0.10 6IAA-A nrPDB 35 0.12 4TUF-A nrPDB 35 0.13 1RHI-3 nrPDB 35 0.13 4B3K-A nrPDB 34 0.14 3VIK-A nrPDB 34 0.15 4U5I-A nrPDB 34 0.15 5CG0-A nrPDB 34 0.16 6IK8-B nrPDB 34 0.17 5Z6P-A nrPDB 34 0.20 1G01-A nrPDB 34 0.25 4HA4-A nrPDB 34 0.27 2X5I-C nrPDB 34 0.27 3ZJ8-A nrPDB 34 0.30 5E9A-A nrPDB 33 0.33 1PBG-A nrPDB 33 0.34 1ND3-C nrPDB 33 0.37 4TLZ-A nrPDB 33 0.42 4MAD-A nrPDB 33 0.44 5BX9-A nrPDB 33 0.51 5WH8-A nrPDB 32 0.61 5UC7-A nrPDB 32 0.85 4L4P-A nrPDB 32 0.95 2O2Y-A nrPDB 32 1.0 3WDP-P nrPDB 32 1.1 5VAQ-A nrPDB 31 1.4 1QOX-A nrPDB 31 1.4 3TTS-A nrPDB 31 1.5 6ACY-C nrPDB 31 1.7 6HBG-C nrPDB 31 1.7 1XC6-A nrPDB 30 2.0 5GSM-A nrPDB 30 2.2 4RNX-A nrPDB 30 2.2 6IGZ-9 nrPDB 30 2.3 5JBO-A nrPDB 30 2.4 4RNU-A nrPDB 30 2.5 4OJY-A nrPDB 30 2.5 5WI9-A nrPDB 30 2.6 4W8L-A nrPDB 30 2.6 1ECE-A nrPDB 30 2.7 4Y7E-A nrPDB 30 2.8 6GP5-A nrPDB 30 3.0 6HIZ-Ck nrPDB 30 3.1 6GPA-A nrPDB 30 3.3 1BGG-A nrPDB 30 3.4 4IPN-B nrPDB 30 3.4 3AC0-A nrPDB 30 3.5 4LX4-A nrPDB 30 3.5 4C9D-A nrPDB 30 4.3 2WSI-A nrPDB 30 4.3 5IDI-A nrPDB 30 4.3 5XGZ-A nrPDB 29 4.6 4MDP-A nrPDB 29 4.8 1J10-A nrPDB 29 4.8 6ENS-A nrPDB 29 5.1 5ECU-A nrPDB 29 5.9 5NS7-A nrPDB 29 6.4 3NCO-A nrPDB 29 7.3 3W53-A nrPDB 29 7.4 4GBU-A nrPDB 29 9.5 >3K4D-A nrPDB Length = 605 Score = 851 bits (2199), Expect = 0.0, Method: Composition-based stats. Identities = 603/603 (100%), Positives = 603/603 (100%) Query: 1 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI 60 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI Sbjct: 3 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI 62 Query: 61 RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP 120 RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP Sbjct: 63 RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP 122 Query: 121 YVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTP 180 YVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTP Sbjct: 123 YVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTP 182 Query: 181 NTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVVNPH 240 NTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVVNPH Sbjct: 183 NTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVVNPH 242 Query: 241 LWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHEDAD 300 LWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHEDAD Sbjct: 243 LWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHEDAD 302 Query: 301 LRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLS 360 LRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLS Sbjct: 303 LRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLS 362 Query: 361 LGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQG 420 LGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQG Sbjct: 363 LGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQG 422 Query: 421 AREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLET 480 AREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLET Sbjct: 423 AREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLET 482 Query: 481 AEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRV 540 AEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRV Sbjct: 483 AEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRV 542 Query: 541 SAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMNFGEKPQQG 600 SAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMNFGEKPQQG Sbjct: 543 SAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMNFGEKPQQG 602 Query: 601 GKQ 603 GKQ Sbjct: 603 GKQ 605 >6CXS-A nrPDB Length = 602 Score = 720 bits (1858), Expect = 0.0, Method: Composition-based stats. Identities = 285/603 (47%), Positives = 398/603 (66%), Gaps = 12/603 (1%) Query: 1 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI 60 ML P+ T +R++ L G+W F L+ N G+ + ++ L+++ +AVP S+ND ++ Sbjct: 4 MLYPIITESRQLIDLSGIWKFKLNEGN-GLTEELSKAPLEDTIEMAVPSSYNDLVESQEV 62 Query: 61 RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP 120 R++ G VWY+R IPK +RIVLRF + TH KV++N + ++EH+GG+TPFEA++ Sbjct: 63 RDHVGWVWYERNFTIPKTLLNERIVLRFGSATHEAKVYLNGELLVEHKGGFTPFEAEIND 122 Query: 121 YVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKK---QSYFHDFFNYAGIHRSVMLY 177 +++G R+TV VNN ++ T+P G+V E KK S DFFNYAGIHR V +Y Sbjct: 123 LLVSGD-NRLTVAVNNIIDETTLPVGLVKEVEVDGKKVIKNSVNFDFFNYAGIHRPVKIY 181 Query: 178 TTPNTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVV 237 TTP ++++DIT+VT ++ + + + Q V ++ V + D + +VA G+G G L + Sbjct: 182 TTPKSYIEDITIVTDFKENNGYVNYEVQAVGKCNIKVTIIDEENNIVAEGEGKEGKLTIN 241 Query: 238 NPHLWQPGEGYLYELCVTAKSQTEC-DIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRH 296 N HLW+P YLY+L V E D Y G+R+V VK +FLIN+KPFYF GFG+H Sbjct: 242 NVHLWEPMNAYLYKLKVELLDDEEIIDTYFEEFGVRTVEVKDGKFLINNKPFYFKGFGKH 301 Query: 297 EDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVG 356 ED+ + G+G + + + D LM WIGANS+RTSHYPY+EE++ AD GIVVIDET AVG Sbjct: 302 EDSYVNGRGINEAINIKDFNLMKWIGANSFRTSHYPYSEEIMRLADREGIVVIDETPAVG 361 Query: 357 FNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDT 416 +L+ G+ PK +E T++AH + ++EL++RDKNHP VVMWS+ANEPD+ Sbjct: 362 LHLNFMATGFGGDAPKRDTWKEI---GTKEAHERILRELVSRDKNHPCVVMWSVANEPDS 418 Query: 417 RPQGAREYFAPLAEATRKLDP-TRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQS 475 +GA+EYF PL + T++LDP RP+T V + + D+ DVLCLNRYYGWYV Sbjct: 419 DSEGAKEYFEPLIKLTKELDPQKRPVTVVTYLMSTPDRCKVGDIVDVLCLNRYYGWYVAG 478 Query: 476 GDLETAEKVLEKELLAWQEKLHQ-PIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYH 534 GDLE A+++LE EL W+E+ + PI+ TEYG DT+AGLH M++EEYQ + H Sbjct: 479 GDLEEAKRMLEDELKGWEERCPKTPIMFTEYGADTVAGLHDTVPVMFTEEYQVEYYKANH 538 Query: 535 RVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGM-NF 593 V D+ VGEQVWNFADFATSQGI+RV GNKKGIFTR+RKPK A L++RWT + F Sbjct: 539 EVMDKCKNFVGEQVWNFADFATSQGIIRVQGNKKGIFTRERKPKMIAHSLRERWTNIPEF 598 Query: 594 GEK 596 G K Sbjct: 599 GYK 601 >5C70-A nrPDB Length = 612 Score = 718 bits (1852), Expect = 0.0, Method: Composition-based stats. Identities = 332/608 (54%), Positives = 431/608 (70%), Gaps = 13/608 (2%) Query: 1 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI 60 ML+P +T TR++ LDGLW F+L ++ + + W S L+ S VP S+ND FAD+ I Sbjct: 9 MLKPQQTTTRDLISLDGLWKFALASDDN--NTQPWTSQLKTSLECPVPASYNDIFADSKI 66 Query: 61 RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP 120 ++ G V+YQR+V +PKGW+ +R ++R +A TH+G+++VN V +H GGYTPFEAD+T Sbjct: 67 HDHVGWVYYQRDVIVPKGWSEERYLVRCEAATHHGRIYVNGNLVADHVGGYTPFEADITD 126 Query: 121 YVIAGKSVRITVCVNNELNWQTIPPGMV-ITDENGKKKQSYFHDFFNYAGIHRSVMLYTT 179 V AG+ R+T+ V+NEL +QTIPPG V I + GKK Q+Y HDF+NYAG+ RSV LY+ Sbjct: 127 LVAAGEQFRLTIAVDNELTYQTIPPGKVEILEATGKKVQTYQHDFYNYAGLARSVWLYSV 186 Query: 180 PNTWVDDITVVTHVAQDCNHASVDWQVVAN---GDVSVELRDADQQVVATGQGTSGTLQV 236 P + DITV T V +D+ VVA+ G + V + D D VAT G++GT+ + Sbjct: 187 PQQHIQDITVRTDVQ--GTTGLIDYNVVASTTQGTIQVAVIDEDGTTVATSSGSNGTIHI 244 Query: 237 VNPHLWQPGEGYLYELCVTAKS--QTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFG 294 + HLWQPG YLY+L + + D Y L GIR+V V+G QFLIN KPFYFTGFG Sbjct: 245 PSVHLWQPGAAYLYQLHASIIDSSKKTIDTYKLATGIRTVKVQGTQFLINDKPFYFTGFG 304 Query: 295 RHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAA 354 +HED ++RGKG D+ MVHD L+ W+GANS+RTSHYPYAEE++++AD GIVVIDET A Sbjct: 305 KHEDTNIRGKGHDDAYMVHDFQLLHWMGANSFRTSHYPYAEEVMEYADRQGIVVIDETPA 364 Query: 355 VGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEP 414 VG S+G G + N P +S + +N +T++AH QAI+ELI RDKNHPSVVMWSIANEP Sbjct: 365 VGLAFSIGAGAQTSNPPAT-FSPDRINNKTREAHAQAIRELIHRDKNHPSVVMWSIANEP 423 Query: 415 DTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQ 474 + GAREYFAPL + R+LDPTRP+T NV D I+DLFDVLCLNRY+GWY Q Sbjct: 424 ASNEDGAREYFAPLPKLARQLDPTRPVTFANVGLATYKADRIADLFDVLCLNRYFGWYTQ 483 Query: 475 SGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYH 534 + +L+ AE LE+EL W EK +PI++TEYG DT+AGLHS+ WSEE+Q LDMYH Sbjct: 484 TAELDEAEAALEEELRGWTEKYDKPIVMTEYGADTVAGLHSVMVTPWSEEFQVEMLDMYH 543 Query: 535 RVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMNFG 594 RVFDR A+ GEQVWNFADF T+ G+ RV GNKKG+FTRDRKPK+AA LL+KRWT ++ G Sbjct: 544 RVFDRFEAMAGEQVWNFADFQTAVGVSRVDGNKKGVFTRDRKPKAAAHLLRKRWTNLHNG 603 Query: 595 EKPQQGGK 602 +GGK Sbjct: 604 --TAEGGK 609 >6ED2-A nrPDB Length = 631 Score = 704 bits (1816), Expect = 0.0, Method: Composition-based stats. Identities = 269/607 (44%), Positives = 353/607 (58%), Gaps = 12/607 (1%) Query: 1 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI 60 +L P T TR + LDG+W FS D E+ G++ W L S ++ VP SF D F D Sbjct: 28 LLYPRATTTRRLIGLDGMWRFSFDPESKGVEAGW-ALDLPSSLSMPVPASFCDLFTDKAS 86 Query: 61 RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP 120 R Y G+ WY+ F+P W+G IVLRF +VTH +V+VN EV +H+GG+ PF+A VT Sbjct: 87 REYCGDFWYETSFFVPAEWSGWDIVLRFGSVTHRARVFVNGVEVAQHEGGFLPFDATVTN 146 Query: 121 YVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTP 180 V + +++V NNEL+ +P G T +G+K + + DF+NYAGIHR V L P Sbjct: 147 IVRYNQFNKLSVLANNELSETMLPAGTTCTLADGRKIAAPYFDFYNYAGIHRPVWLMALP 206 Query: 181 NTWVDDITVVTHVAQDCNHASVDWQVVANG--DVSVELRDADQQVVATGQGTSGTLQVVN 238 V D + + + A +D+ V NG V+VEL D + VA GT+GTL V N Sbjct: 207 KERVLDYSTRYRLTETG--AEIDYTVSTNGPHPVTVELYDGTTR-VAESSGTTGTLVVKN 263 Query: 239 PHLWQPGEGYLYELCVTA-KSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHE 297 LW YLY+L + + D Y R+GIR+ ++ +FL+N P Y GFGRHE Sbjct: 264 ARLWNVHAAYLYDLVIRIHEGSAVVDEYLDRIGIRTFEIRHGRFLLNGSPVYLRGFGRHE 323 Query: 298 DADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGF 357 DAD+RG+G D + D LM WIGAN +RTSHYPYAEE+ ADE G ++IDE AVGF Sbjct: 324 DADIRGRGLDLPTVKRDFELMKWIGANCFRTSHYPYAEEIYQMADEEGFLIIDEVPAVGF 383 Query: 358 NLSLGI--GFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPD 415 S GN ++ + E+ + H A+ ++I RDKNHPSV+ WS+ NEP Sbjct: 384 MQSTANFLAANQGNGRQQGFFEKETTPALLKNHKAALTDMIDRDKNHPSVIAWSLLNEPQ 443 Query: 416 TRPQGAREYFAPLAEATRKLDP-TRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQ 474 G EYF PL E R+LDP RP T +M T D + LNRYYGWYV Sbjct: 444 CTSAGTEEYFKPLFELARRLDPQKRPRTYTVLMTSLPDTSKGQRFADFVSLNRYYGWYVL 503 Query: 475 SG-DLETAEKVLEKELLAWQEKLH-QPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDM 532 G L AE E+ W + LH +P+I TEYG D L+G H + + MWS EYQ +L+M Sbjct: 504 GGAGLADAEAAFHHEMDGWAKVLHGRPLIFTEYGTDNLSGAHKLPSVMWSAEYQNEYLEM 563 Query: 533 YHRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMN 592 H VFD V GE VWNFADF T++GILRV GNKKGIFTR R+PK AA+L +KRWT + Sbjct: 564 THAVFDHYDFVQGELVWNFADFQTTEGILRVDGNKKGIFTRQRQPKDAAYLFRKRWTTLP 623 Query: 593 FGEKPQQ 599 K ++ Sbjct: 624 VDFKKRK 630 >6BJW-A nrPDB Length = 635 Score = 699 bits (1804), Expect = 0.0, Method: Composition-based stats. Identities = 276/619 (44%), Positives = 382/619 (61%), Gaps = 29/619 (4%) Query: 1 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI 60 ML PV T +R + L G+W F LD G +++W+E L+++ + VP S+ND D Sbjct: 25 MLYPVLTQSRLLSDLSGVWDFKLDNGK-GFEEKWYEKPLKDADTMPVPASYNDLKEGTDF 83 Query: 61 RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP 120 R++ G V+YQR + +P+ QRIVLR AVTHY +++N + + EH+GG+ PFE ++ Sbjct: 84 RDHYGWVFYQRNISVPEYVKSQRIVLRCAAVTHYAMIYLNGKLICEHKGGFLPFEVELND 143 Query: 121 YVIAGKSVRITVCVNNELNWQTIPPG-----------MVITDENGKKKQSYFHDFFNYAG 169 + G ++ +T+ VNN +++ T+P G + + K + + DFFNY G Sbjct: 144 DLQDGDNL-LTIAVNNVIDYTTLPVGGKANMMSGMMGGMGAGASDKPQNNPNFDFFNYCG 202 Query: 170 IHRSVMLYTTPNTWVDDITVVTHV--AQDCNHASVDWQVVANGD------VSVELRDADQ 221 I R V +YTTP T+++DITV + ++ A +++ V G VEL D + Sbjct: 203 ITRPVKIYTTPETYINDITVTADIDFTKEEPSAVLNYNVEIKGKDYNNITCKVELFDEEG 262 Query: 222 QVVATGQGTSGTLQVVNPHLWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQF 281 ++ +G+ GT ++ N LWQP YLY++ VTA D+Y L G+RSV V G +F Sbjct: 263 TKLSETEGSEGTFEISNVRLWQPLNAYLYKIKVTAGQ----DVYTLPYGVRSVRVDGTKF 318 Query: 282 LINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWA 341 LIN KPFYF G+G+HED G+G + + D ++M W ANS+RTSHYPY+EEM+ Sbjct: 319 LINEKPFYFKGYGKHEDTFPNGRGINLPMNTKDISIMKWQHANSFRTSHYPYSEEMMRLC 378 Query: 342 DEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKN 401 DE GIVVIDET AVG NL G G G + + +E +TQ+ H I++LI+RDKN Sbjct: 379 DEEGIVVIDETTAVGVNLQFGGGANFGGERIGTFDKEH-GVQTQEHHKDVIRDLISRDKN 437 Query: 402 HPSVVMWSIANEPDTRPQGAREYFAPLAEATRKLDP-TRPITCVNVMFCDAHTDTISDLF 460 H VVMWSIANEPD+ +GA +YF PL + R+LDP RP T V+V A TD S L Sbjct: 438 HACVVMWSIANEPDSAAEGAYDYFKPLYDLARELDPQKRPCTLVSVQGTTADTDCSSQLS 497 Query: 461 DVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDM 520 DV+CLNRYYGWY DLE +E L KEL W KL +P++ TEYG DT++GLH + M Sbjct: 498 DVICLNRYYGWYFGGPDLEVSEIGLRKELSDWG-KLGKPVMFTEYGADTVSGLHDTTSVM 556 Query: 521 WSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSA 580 ++EEYQ + +M ++VFD VVGEQ WNFADFATSQ +LRV GNKKG+FTRDRKPK Sbjct: 557 YTEEYQVEYYEMNNKVFDEFDFVVGEQAWNFADFATSQSLLRVQGNKKGLFTRDRKPKMV 616 Query: 581 AFLLQKRWTGM-NFGEKPQ 598 A + RW+ + FG K + Sbjct: 617 AHYFRNRWSTIPEFGYKTK 635 >5Z19-A nrPDB Length = 627 Score = 696 bits (1796), Expect = 0.0, Method: Composition-based stats. Identities = 240/597 (40%), Positives = 343/597 (57%), Gaps = 9/597 (1%) Query: 2 LRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADIR 61 L P++ R ++ LDG+W F D E G + WE+ L ++ VP SF D F D R Sbjct: 31 LYPIQNEYRMMQSLDGMWKFQFDPEEIG-KKSGWENGLPAPVSMPVPSSFADFFTDHKER 89 Query: 62 NYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPY 121 +Y G+ WY+ E ++P W ++I LRF ++TH G V+ N E+ H+GG+ P AD++ Sbjct: 90 DYCGDFWYETEFYLPAEWRNKKIWLRFGSITHRGTVYCNGMEITSHEGGFLPVLADISTV 149 Query: 122 VIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPN 181 G+ ++ V +NNELN ++P G NG+K + DFFNY+G+ RSV + P Sbjct: 150 AKPGQVNQVVVKINNELNETSLPCGATKILNNGRKLAKPYFDFFNYSGLQRSVWVIALPE 209 Query: 182 TWVDDITVVTHVAQDCNHASVDWQVVANGD--VSVELRDADQQVVATGQGTSGTLQVVNP 239 V D +V + A V ++VV G+ V V L DA+ ++VA +G G LQV N Sbjct: 210 ESVKDYSVDYELC--GTDALVKYEVVTTGEHPVIVRLLDAEGELVAETEGKEGILQVANA 267 Query: 240 HLWQPGEGYLYELCVTAKS-QTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHED 298 LW+ YLY++ + D Y ++GIR+V ++G + L+N +P Y GFG+HED Sbjct: 268 RLWEVRNAYLYQIVILITDGNGVLDEYREKIGIRTVRIEGTKILLNDRPVYLKGFGKHED 327 Query: 299 ADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFN 358 + G+GF ++ D + W AN +RTSHYPYAEE +ADE G ++IDE AVG Sbjct: 328 FPILGRGFHWGIVKRDFECLKWTNANCFRTSHYPYAEEWYQFADEEGFLIIDEVPAVGMM 387 Query: 359 LSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRP 418 S AG+ + E E ++H+ +E+I RDKNHPSV+ WS+ NEP+T Sbjct: 388 RSTRNFVAAGSGNYTYFFEALTVPELLKSHIADTEEMITRDKNHPSVIAWSLFNEPETIT 447 Query: 419 QGAREYFAPLAEATRKLD-PTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSG- 476 A EYF + A D +RP+T L D +CLNRYYGWY+ G Sbjct: 448 DYAYEYFKEVFAAAETYDFQSRPMTGAFEKNSKPELCKCYPLCDFICLNRYYGWYISGGP 507 Query: 477 DLETAEKVLEKELLAWQEK-LHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHR 535 ++E AE++ E+ W+ K L+ P + TE+G DT+AGLH + + MWSEEYQ +L+M R Sbjct: 508 EIEEAEELFRDEMDRWKAKELNVPFVFTEFGTDTMAGLHKLPSIMWSEEYQKEYLEMNFR 567 Query: 536 VFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMN 592 VFD V GE WNFADF T++GI+RV GN KG+FTRDR+PK+AA + + RW N Sbjct: 568 VFDSYEFVQGELAWNFADFQTTEGIMRVDGNHKGVFTRDRQPKAAAVVFKDRWEKKN 624 >6ECA-A nrPDB Length = 627 Score = 693 bits (1788), Expect = 0.0, Method: Composition-based stats. Identities = 263/605 (43%), Positives = 349/605 (57%), Gaps = 13/605 (2%) Query: 1 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI 60 +L PV R +KLDGLW F D G ++ WE+ + ++ VP SFND F D Sbjct: 29 LLYPVTNDQRTDQKLDGLWQFKFDEAGEG-EKSGWETGFHDGVSMPVPASFNDFFTDKAS 87 Query: 61 RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP 120 R Y G+ WY R F+P G+ + LRFDAVTH ++VN +E+ H+GG+ PF AD++ Sbjct: 88 REYTGDFWYSRNFFVPSAAKGKALFLRFDAVTHRATIFVNGKEIRTHEGGFLPFAADISE 147 Query: 121 YVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTP 180 V G + V NNEL+ + +P G IT NGKK F DF+NY+G++RSV L + P Sbjct: 148 AVKYGAENTVVVKGNNELSREALPAGDTITLRNGKKMVRPFFDFYNYSGLNRSVHLLSLP 207 Query: 181 NTWVDDITVVTHVAQDCNHASVDWQVVANGD--VSVELRDADQQVVATGQGTSGTLQVVN 238 V D T +A N A+V++ V NGD V+V L DAD QVVAT QG G LQV N Sbjct: 208 QERVLDYTTTFALA--GNDATVNYTVETNGDAPVTVSLADADGQVVATAQGKQGALQVQN 265 Query: 239 PHLWQPGEGYLYELCVTAKSQTEC--DIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRH 296 HLWQ YLY L + T+ D Y R+GIR++ + G L+N KP Y GFGRH Sbjct: 266 AHLWQVRNAYLYTLTIQLGDDTQTPLDTYTDRIGIRTIKISGTDILVNDKPIYLKGFGRH 325 Query: 297 EDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVG 356 ED+ G+ FD + D ALM WIGANS+RTSHYPY E++ ADE G ++ DE AVG Sbjct: 326 EDSPFAGRAFDLNVEKKDFALMKWIGANSFRTSHYPYDEQVYKIADEEGFLLTDEVPAVG 385 Query: 357 FNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDT 416 F ++ N+ + + + + H+ I++LI RDKNHPSV+ WS+ NEPDT Sbjct: 386 FKMAAAAFLGGLNQS---FFKGPWLKKLHERHIDQIRDLIKRDKNHPSVLAWSLFNEPDT 442 Query: 417 RPQGAREYFAPLAEATRKLDPT-RPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQS 475 + A YF + + ++ LDP RP T T + D D LNRY GWY Sbjct: 443 IDENAVPYFKQIFDESKDLDPQGRPRTFTLSEDDTIETSKVLDFPDFYMLNRYPGWYHFG 502 Query: 476 G-DLETAEKVLEKELLAWQE-KLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMY 533 G + E L E+ WQ+ + +P++ TE+G DT AGLH + + MW+EEYQ L M+ Sbjct: 503 GYQISDGEAGLRDEMDKWQKAGVKKPVVFTEFGADTEAGLHKLPSVMWTEEYQVEVLKMF 562 Query: 534 HRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMNF 593 RVFD + GEQVWN ADF T +G +RV GNKKGIFTRDR+PK+AAF RW + Sbjct: 563 SRVFDDYDFIKGEQVWNLADFQTVEGNMRVNGNKKGIFTRDRQPKAAAFFYHDRWNKLPL 622 Query: 594 GEKPQ 598 K + Sbjct: 623 DYKAK 627 >4JKL-A nrPDB Length = 602 Score = 659 bits (1700), Expect = 0.0, Method: Composition-based stats. Identities = 251/601 (41%), Positives = 351/601 (58%), Gaps = 23/601 (3%) Query: 1 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI 60 ML P+ T TR L G+W F L N L + +P SFND + Sbjct: 4 MLYPLLTKTRNTYDLGGIWNFKLGEHNPN-------ELLPSDEVMVIPTSFNDLMVSKEK 56 Query: 61 RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP 120 R+Y G+ WY++ + +PK + +VLRF +VTH K++V+ V EH+GG+TPFE V Sbjct: 57 RDYIGDFWYEKVIEVPKVSEDEEMVLRFGSVTHQAKIYVDGVLVGEHKGGFTPFEVLVPE 116 Query: 121 YVIAGKSVRITVCVNNELNWQTIPPG----MVITDENGKKKQSYFHDFFNYAGIHRSVML 176 + +++++C NN L++ T+P G ++ D + KKK DFFNYAG+HR + L Sbjct: 117 CKYNNEKIKVSICANNVLDYTTLPVGNYSEIIQEDGSIKKKVRENFDFFNYAGVHRPLKL 176 Query: 177 YTTPNTWVDDITVVTHVAQDCNHASVDWQVVANGDV---SVELRDADQQVVATGQGTSGT 233 P + DIT+ + ++ D A + + V N V + + D D ++V G+ Sbjct: 177 MIRPKNHIFDITITSRLSDDLQSADLHFLVETNQKVDEVRISVFDEDNKLV--GETKDSR 234 Query: 234 LQVVNPHLWQPGEGYLYELCVTA-KSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTG 292 L + + HLW+ YLY V D+Y G+R + V QFL+N KP YF G Sbjct: 235 LFLSDVHLWEVLNAYLYTARVEIFVDNQLQDVYEENFGLREIEVTNGQFLLNRKPIYFKG 294 Query: 293 FGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDET 352 FG+HED + G+G + + D L+ +GANS+RTSHYPY+EEM+ AD G++VIDE Sbjct: 295 FGKHEDTFINGRGLNEAANLMDLNLLKDMGANSFRTSHYPYSEEMMRLADRMGVLVIDEV 354 Query: 353 AAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIAN 412 AVG + + K ++ +T+ AH QAI+EL+ RDKNHPSVVMW +AN Sbjct: 355 PAVGLFQNFNASLDLSPKDNGTWN----LMQTKAAHEQAIQELVKRDKNHPSVVMWVVAN 410 Query: 413 EPDTRPQGAREYFAPLAEATRKLDP-TRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGW 471 EP + GA +YF PL + + LDP RP+T VN++ D + DL DV+CLNRYYGW Sbjct: 411 EPASHEAGAHDYFEPLVKLYKDLDPQKRPVTLVNILMATPDRDQVMDLVDVVCLNRYYGW 470 Query: 472 YVQSGDLETAEKVLEKELLAWQEKL-HQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWL 530 YV GDL AE + KELL WQ+K +PIIITEYG DTL GLHS + ++EE+QC + Sbjct: 471 YVDHGDLTNAEVGIRKELLEWQDKFPDKPIIITEYGADTLPGLHSTWNIPYTEEFQCDFY 530 Query: 531 DMYHRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTG 590 +M HRVFD + +VGEQVWNFADF T+ ILRV GN KG+F+R+R+PK +KRW Sbjct: 531 EMSHRVFDGIPNLVGEQVWNFADFETNLMILRVQGNHKGLFSRNRQPKQVVKEFKKRWMT 590 Query: 591 M 591 + Sbjct: 591 I 591 >3HN3-A nrPDB Length = 613 Score = 642 bits (1655), Expect = 0.0, Method: Composition-based stats. Identities = 278/622 (44%), Positives = 366/622 (58%), Gaps = 50/622 (8%) Query: 1 MLRPVETPTREIKKLDGLWAFSLD---RENCGIDQRWWESALQESRA---IAVPGSFNDQ 54 ML P E+P+RE K+LDGLW+F D G +++W+ L ES + VP SFND Sbjct: 7 MLYPQESPSRECKELDGLWSFRADFSDNRRRGFEEQWYRRPLWESGPTVDMPVPSSFNDI 66 Query: 55 FADADIRNYAGNVWYQREVFIPKGWAGQ---RIVLRFDAVTHYGKVWVNNQEVMEHQGGY 111 D +R++ G VWY+REV +P+ W R+VLR + Y VWVN + +EH+GGY Sbjct: 67 SQDWRLRHFVGWVWYEREVILPERWTQDLRTRVVLRIGSAHSYAIVWVNGVDTLEHEGGY 126 Query: 112 TPFEADVTPYVIAG---KSVRITVCVNNELNWQTIPPGMVITDENGKK------KQSYFH 162 PFEAD++ V G +RIT+ +NN L T+PPG + + K Q+ + Sbjct: 127 LPFEADISNLVQVGPLPSRLRITIAINNTLTPTTLPPGTIQYLTDTSKYPKGYFVQNTYF 186 Query: 163 DFFNYAGIHRSVMLYTTPNTWVDDITVVTHVAQDCNHASVDWQVVANG--DVSVELRDAD 220 DFFNYAG+ RSV+LYTTP T++DDITV T V QD + V + + V L DA+ Sbjct: 187 DFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQDSGLVNYQISVKGSNLFKLEVRLLDAE 246 Query: 221 QQVVATGQGTSGTLQVVNPHLWQP-----GEGYLYELCVTAKSQT----ECDIYPLRVGI 271 +VVA G GT G L+V LW P YLY L V +QT D Y L VGI Sbjct: 247 NKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYLYSLEVQLTAQTSLGPVSDFYTLPVGI 306 Query: 272 RSVAVKGEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHY 331 R+VAV QFLIN KPFYF G +HEDAD+RGKGFD L+V D L+ W+GAN++RTSHY Sbjct: 307 RTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHY 366 Query: 332 PYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQA 391 PYAEE++ D +GIVVIDE VG L + N + H+Q Sbjct: 367 PYAEEVMQMCDRYGIVVIDECPGVGLALP-----------------QFFNNVSLHHHMQV 409 Query: 392 IKELIARDKNHPSVVMWSIANEPDTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDA 451 ++E++ RDKNHP+VVMWS+ANEP + + A Y + T+ LDP+RP+T V+ + Sbjct: 410 MEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVTFVSN--SNY 467 Query: 452 HTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLA 511 D + DV+CLN YY WY G LE + L + W +K +PII +EYG +T+A Sbjct: 468 AADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIA 527 Query: 512 GLHSMYTDMWSEEYQCAWLDMYHRVFD--RVSAVVGEQVWNFADFATSQGILRVGGNKKG 569 G H M++EEYQ + L+ YH D R VVGE +WNFADF T Q RV GNKKG Sbjct: 528 GFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKG 587 Query: 570 IFTRDRKPKSAAFLLQKRWTGM 591 IFTR R+PKSAAFLL++R+ + Sbjct: 588 IFTRQRQPKSAAFLLRERYWKI 609 >5Z1B-A nrPDB Length = 692 Score = 630 bits (1624), Expect = 0.0, Method: Composition-based stats. Identities = 262/688 (38%), Positives = 357/688 (51%), Gaps = 113/688 (16%) Query: 1 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI 60 ML P +R + LDG+W F E+ W ++ L E +AVPGS+NDQ + ++ Sbjct: 25 MLYPQSNDSRIVFPLDGVWDFRTAGEDS-YPAEWADAPLPEPLPMAVPGSYNDQNDELNL 83 Query: 61 RNYAGNVWYQREVFIPKGW-AGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVT 119 R + G V YQR +P AGQR++LRFDA TH V++N Q + H GG+ PFE DVT Sbjct: 84 RAHYGWVVYQRSFAVPSRLVAGQRMILRFDAATHAADVYLNGQLLGSHFGGFLPFEFDVT 143 Query: 120 PYVIAGKSVRITVCVNNELNWQTIPPG-----------------MVITDENGKKKQSYFH 162 + AG+++ +TV V+N + T+P G + ++ +++ Sbjct: 144 SALHAGENL-LTVAVDNRIGSSTLPVGNDAGTAFMGSDNANVPAVAEAKKHARRQNLPNF 202 Query: 163 DFFNYAGIHRSVMLYTTPN-TWVDDITVVTH-------VAQDCNHASVDWQVVANGD--- 211 DFFN+AG++R V LYTTP ++ DI + T A +A + + V GD Sbjct: 203 DFFNFAGLNRHVELYTTPADAYIADIAITTERLDHIAGDACTAANALIAYDVTFGGDFPS 262 Query: 212 --------------------------------------VSVELRDADQQVVA-------- 225 V + + D + VVA Sbjct: 263 NPTDPNTLIQPSDPAINHADPSESSESDIQRTATYGRQVRISILDGEGTVVAGVTADIER 322 Query: 226 TGQGT---SGTLQVVNPHLWQPGEGYLYELCVTA-------KSQTECDIYPLRVGIRSVA 275 +G GT SG + + + LW PG YLY S D Y GIR+V Sbjct: 323 SGDGTAKASGEIAIRDAKLWNPGAAYLYTAVAELLPEGGAESSSRIIDAYRQTFGIRTVE 382 Query: 276 VKGEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAE 335 V G FLIN KPFYF GFG+HED+ G+G D+VL V D +L+ W+ ANS+RTSHYPYAE Sbjct: 383 VSGTTFLINGKPFYFKGFGKHEDSYFHGRGTDDVLNVKDVSLIHWLHANSFRTSHYPYAE 442 Query: 336 EMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKEL 395 M D D GIV+IDE AVG + + N + H +AI+ + Sbjct: 443 SMYDLCDREGIVIIDEVPAVGMSWL-----------------QYANPLVAERHREAIRGM 485 Query: 396 IARDKNHPSVVMWSIANEP-----DTRPQGAREYFAPLAEATRKLDP-TRPITCVNVMFC 449 IARDKNHP +VMWSIAN P RP+ A +YF PL E DP RP+T V Sbjct: 486 IARDKNHPCIVMWSIANAPGLDGDGERPRQAYDYFRPLYELAHASDPQNRPVTLVCCQ-N 544 Query: 450 DAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDT 509 D TD DV+C+NRYYGWY SGDL+ A L EL W E + +P++ TEYG DT Sbjct: 545 DYTTDITERTMDVVCINRYYGWYNLSGDLDAACHALNIELDFW-ENIGKPVMFTEYGADT 603 Query: 510 LAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKG 569 + G+H + +M+SEE+Q + + D+ +GEQ+WNFADFAT QGI+RV GN+KG Sbjct: 604 IEGIHGTHGEMFSEEFQRDYYARINAEIDKRPWFIGEQLWNFADFATFQGIIRVEGNRKG 663 Query: 570 IFTRDRKPKSAAFLLQKRWTGM-NFGEK 596 I TRDR+PK AA L++RW G+ ++G K Sbjct: 664 ILTRDRQPKMAAHWLRERWAGIPDYGYK 691 >6MVG-A nrPDB Length = 777 Score = 529 bits (1363), Expect = e-150, Method: Composition-based stats. Identities = 154/621 (24%), Positives = 247/621 (39%), Gaps = 94/621 (15%) Query: 2 LRPVETPTREIKKLDGLWAFSLD--RENCGIDQRWWESALQESRAIAVPGSFNDQF-ADA 58 L REI L+ WAFS + + + Q W+ + +P ++N D Sbjct: 17 LYFQSNAMREIFNLNEKWAFSKEAIKPPVAMPQNWYW--------VNLPHTWNAIDGQDG 68 Query: 59 DIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADV 118 Y G +Y +EV + G++ L F V V+VN + H GGY+ + ++ Sbjct: 69 GNDYYRGTCFYAKEVQKEELPEGEQYYLEFLGVNASADVYVNGNHLDHHDGGYSTWRVNM 128 Query: 119 TPYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYT 178 T + GK++ I V V+N N + P DF Y G++R V + Sbjct: 129 TDALTDGKNL-IVVAVDNSANDRVYPQKA---------------DFTFYGGMYRDVNIIA 172 Query: 179 TPNTWVD-------DITVVTHVAQDCNHASVDWQVVANGD-----VSVELRDADQQVVAT 226 + D + V VA +A + +V +G+ + ++ DA+ + A Sbjct: 173 VNKSHFDLDYYGGNGLKVTPEVAD--KNAKIAVEVFLSGEKAGQQLVYQITDAEGVLAAE 230 Query: 227 G----QGTSGTLQVVNPHLWQP-GEGYLYELCVTAKSQTEC-DIYPLRVGIRSVAVKGE- 279 L++ + HLW + YLY V C D R G R+ + + Sbjct: 231 TKTGISDKQVNLEITDVHLWNGRKDPYLYTATVRLMEDGVCIDSVSTRFGCRTFTIDPDK 290 Query: 280 QFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLD 339 F +N + G RH+D G D L+ +GA + R +HY +A+ D Sbjct: 291 GFFLNGNSYPLRGVSRHQDRAGNGNALLPEHHREDIDLICEMGATTIRLAHYQHAQYFYD 350 Query: 340 WADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARD 399 DE G+V+ E + ++ G ++ + +KELI ++ Sbjct: 351 LCDEKGLVLWAEIPYISQHMKNG----------------------RENTISQMKELIVQN 388 Query: 400 KNHPSVVMWSIANEP---DTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTI 456 NHPS+V+W ++NE + E L + ++DPTR T V CD H + Sbjct: 389 YNHPSIVVWGLSNEITMSGEADEDLMENHHILNDLAHEMDPTRLTTMAVVSMCDMH-NPY 447 Query: 457 SDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQ-----PIIITEYGVDTLA 511 + DV+ N Y+GWY GD W ++ H+ PI ++EYG + L Sbjct: 448 IQIPDVVSYNHYFGWY--GGDTSM--------NGPWMDEFHKEFPKIPIGMSEYGCEAL- 496 Query: 512 GLHSMYTDM--WSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATS--QGILRVGGNK 567 H+ ++EEYQ + + + + VWN DFA G N Sbjct: 497 NWHTSDPKQGDYTEEYQAHYHEELIKQLYTRPYIWATHVWNMFDFAADARNEGGENGMNH 556 Query: 568 KGIFTRDRKPKSAAFLLQKRW 588 KG+ T DRK K AF K W Sbjct: 557 KGLVTFDRKYKKDAFYAYKAW 577 >6D8G-A nrPDB Length = 886 Score = 518 bits (1333), Expect = e-147, Method: Composition-based stats. Identities = 155/640 (24%), Positives = 255/640 (39%), Gaps = 99/640 (15%) Query: 1 MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFN-DQFADAD 59 +L PV R+ + ++ W F D + +S +I +P ++N D + + D Sbjct: 25 VLPPVHA-QRQTQTINDSWKFLKGECTAAADSAFDDSKW---TSIHLPHTWNTDAYTEKD 80 Query: 60 IRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVT 119 Y G WY+R++ +P+GW ++I+LR DA +++N + V EH GGYT ++T Sbjct: 81 --YYRGTGWYRRQLTLPQGWKEKQIILRLDAAGKSATIYINGKNVGEHAGGYTACSFNIT 138 Query: 120 PYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTT 179 P++ + VCV+N DF + GI+R V L Sbjct: 139 PFLSFDTPNTLAVCVDNARQD----------------IAPISGDFTFFGGIYRDVWLTAV 182 Query: 180 PNTWV-------DDITV-VTHVAQDCNHASVDWQVVANGDVSVEL--------------- 216 PN D + + V+++ S+ +V + L Sbjct: 183 PNQHFNLTNHGSDGLFISTPQVSEEQATLSIRGEVKNDAPEKATLELTHTIYRPDGTLLQ 242 Query: 217 ---RDADQQVVATGQGTSGTLQVVNPHLWQPGEGYLYELCVTA---KSQTECDIYPLRVG 270 ++ + T ++ V+ P LW P LY + T K++T D Sbjct: 243 TLKKNIQLKAGETYAFSNEATPVLKPELWTPETPRLYRVETTLRNRKTKTLLDQSNHYTA 302 Query: 271 IRSVAVKGE-QFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTS 329 R G+ F +N KP+ G RH+D G + D LM +GAN R S Sbjct: 303 FRWFRFDGDEGFFLNGKPYKLRGICRHQDQKPIGPALTAEMHRRDFLLMKEMGANFIRIS 362 Query: 330 HYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHL 389 HYP A+ +L+ D+ G++ +E + + Sbjct: 363 HYPQADALLEMCDKLGMLAWEEIPIIDIVPNT--------------------PGYGDNCE 402 Query: 390 QAIKELIARDKNHPSVVMWSIANEP---DTRPQGAREYFAPLAEAT-----------RKL 435 + ++E+I + NHPS++ W NE R P+ E T ++ Sbjct: 403 RNLREMIRQHYNHPSIITWGYMNEILLVTQRKYKTEAELKPVLERTLALANRLERVLKEE 462 Query: 436 DPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEK 495 D TR T + +S + D++ N Y GWY GDL EK L ++ Q Sbjct: 463 DSTRISTMAFHGSNSYNETGLSKITDIVGWNLYQGWY--GGDLTGFEKFLAQQ---HQNH 517 Query: 496 LHQPIIITEYGVDTLAGLHSMYTDM--WSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFAD 553 P+I++EYG + LHS++ +S EYQ +L+ Y V + + G WNF D Sbjct: 518 PTHPMIVSEYGAGSDKRLHSLHPRAFDFSIEYQQKYLEHYLPVLEDTPYICGGTHWNFID 577 Query: 554 FATS---QGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTG 590 F+++ + + R+ N KG+ DR PK Q W Sbjct: 578 FSSALRDESMPRI--NNKGLVYADRTPKDVYHYYQAAWRK 615 >6MVH-A nrPDB Length = 780 Score = 512 bits (1319), Expect = e-145, Method: Composition-based stats. Identities = 142/620 (22%), Positives = 241/620 (38%), Gaps = 92/620 (14%) Query: 2 LRPVETPTREIKKLDGLWAFSLDRENCG--IDQRWWESALQESRAIAVPGSFNDQF-ADA 58 L RE+ + WAF+ + + ++W+ + +P S+N+ D Sbjct: 17 LYFQSNAMREVINFNTKWAFTKEATEVPKEMPEKWYW--------VTLPHSWNEIDGQDG 68 Query: 59 DIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADV 118 Y G +Y +++ + L V+VN + V H GGY+ + D+ Sbjct: 69 GNDYYRGTCYYAKQLKKSELPEADCYYLELRGANASADVYVNGKAVAHHDGGYSTWRVDI 128 Query: 119 TPYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYT 178 T + + I + V N +N + P DF Y G++R V + Sbjct: 129 TKELTE-EENLIVIAVENGVNDRVYPQNA---------------DFTFYGGLYRDVNIIA 172 Query: 179 TPNTWVD-------DITVVTHVAQDCNHASVDW---QVVANGDVSVELRDADQQVVATGQ 228 + D I V + V+ A+ + ++DA+ + VA + Sbjct: 173 VNKSHFDLDYYGGPGIKVTPEIKGADASVEVEVFLTNAAADQKLVYTVKDAEGKEVAKTE 232 Query: 229 GTSGT----LQVVNPHLWQPG-EGYLYELCV-TAKSQTECDIYPLRVGIRSVAVKGE-QF 281 +G L + HLW + YLY V + D R G R+ + E F Sbjct: 233 TAAGETKAVLSIPAVHLWNGKKDPYLYTAEVALVSGEEAVDAVSTRFGCRTFEIDPERGF 292 Query: 282 LINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWA 341 ++N + + G RH+D G D L+ +GA + R +HY + + D Sbjct: 293 ILNGEEYPLRGVSRHQDRWGIGNALLPEHHREDIDLICELGATTIRLAHYQHDQYFYDLC 352 Query: 342 DEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKN 401 DE G+V+ E + ++ G ++ + +KEL+ ++ N Sbjct: 353 DERGLVIWAEIPYISSHMPNG----------------------RENTISQMKELVVQNYN 390 Query: 402 HPSVVMWSIANEP---DTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISD 458 HPS+V+W ++NE + + E L + ++D TR T V CD H D Sbjct: 391 HPSIVVWGLSNEITMAGSSDEDLLENHRILNDMVHEMDHTRLTTIAVVSMCDIH-DPYIQ 449 Query: 459 LFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQ-----PIIITEYGVDTLAGL 513 + DV+ N Y+GWY GD+ W + H+ P+ ++EYG + L Sbjct: 450 IPDVISYNHYFGWY--GGDVSM--------NGPWMDNFHKEFPNIPLGMSEYGCEAL-NW 498 Query: 514 HSMYTDM--WSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADF---ATSQGILRVGGNKK 568 H+ ++EEYQ + + + + VWN DF A ++G G N K Sbjct: 499 HTSDPKQGDYTEEYQAYYHEEMIKQLFTRKYIWATHVWNMFDFGADARNEG-GENGQNHK 557 Query: 569 GIFTRDRKPKSAAFLLQKRW 588 G+ T DRK K +F K W Sbjct: 558 GLVTFDRKYKKDSFYAYKAW 577 >6ED1-A nrPDB Length = 879 Score = 504 bits (1297), Expect = e-143, Method: Composition-based stats. Identities = 147/633 (23%), Positives = 242/633 (38%), Gaps = 91/633 (14%) Query: 2 LRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADIR 61 L + + W + + + W +S + + +P ++N + R Sbjct: 18 LYFQSNASE--ISITDSWKYKAENDERFSSMDWNDS---DWVTVDLPHTWNAGDVIDEQR 72 Query: 62 NYA-GNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP 120 Y G WY++++FIP ++I LRFD V V++N + + H G YT F D+T Sbjct: 73 GYRRGISWYRKKLFIPSEARDKKITLRFDGVASKADVYLNGKLLKTHLGAYTAFGVDITD 132 Query: 121 YVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTP 180 GK + V V+N + I P + DF + GI+R V L T Sbjct: 133 ICEVGKENLLAVKVDNSSSLGEILPPV-------------SGDFSIFGGIYRRVFLQWTE 179 Query: 181 NTWV------------------------DDITVVTHVAQDCNHASVDW-------QVVAN 209 + + + D H V+ ++V Sbjct: 180 KVHFVTEPYAAVPVRIQTPEVSVSEASMQIVAFLKNDFTDTKHVHVNVFLCDEMNRIVKE 239 Query: 210 GDVSVELRDADQQVVATGQGTSGTLQVVNPHLWQPGEGYLYELCVTAKSQTECDIYPL-- 267 + ++L + ++T G ++ NPHLW P YLY + V ++Y Sbjct: 240 KQLKLKLIPGRKYPISTSVG-----RIENPHLWSPELPYLYTVKVQVCDAKNGEMYQEVI 294 Query: 268 -RVGIRSVAVKGEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSY 326 VG R +V F +N K G RH+D G + D L+ +GAN Sbjct: 295 SPVGFRWFSVDKTGFYLNGKYLKLRGAARHQDYAGLGTAIPVEMNRRDMRLLKEMGANFV 354 Query: 327 RTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQ 386 R SHYP E+ DE G++V E V E N Sbjct: 355 RISHYPQDPEIYRACDELGLIVWSEICVVN--------------------EVRKNTAFAH 394 Query: 387 AHLQAIKELIARDKNHPSVVMWSIANEPDTRPQGAREYFAPLAEATRKLDPTRP--ITCV 444 + +KE+I ++ NHPSVV+W NE + A L ++LDP R + Sbjct: 395 NCKEMLKEMILQNYNHPSVVLWGAMNELWDYHKQAIALARELEALKKELDPYRLSCVAFH 454 Query: 445 NVMFCDAHTDTISDLF---DVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPII 501 + +T + ++F DV +N Y WY GD T + +K +P Sbjct: 455 AFTWEKPYTQSSKEMFSISDVNGVNVYESWY--QGDSATIAPMFDK---FCSYSTAKPRF 509 Query: 502 ITEYGVDTLAGLHSMYTDM--WSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATS-Q 558 ++E+G + +HS ++ E+Q + Y ++ +G +WN DF + Sbjct: 510 LSEFGAGSDERIHSYTPRTFDFTPEFQLDFNRRYINEMEKRPDYIGYSIWNLVDFQVDGR 569 Query: 559 GILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGM 591 G + N+KG+ T DR+ K + Q RW+ + Sbjct: 570 GDSKPNLNQKGMLTEDRRKKEIYYYCQARWSDI 602 >3CMG-A nrPDB Length = 667 Score = 493 bits (1269), Expect = e-139, Method: Composition-based stats. Identities = 150/626 (23%), Positives = 237/626 (37%), Gaps = 98/626 (15%) Query: 10 REIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADIRNY-AGNVW 68 R+ L+ W F + G ++R + +P ++N Q A A +Y G Sbjct: 4 RQDILLNNNWNFRFSHQVQG-----------DTRRVDLPHTWNAQDALAGKIDYKRGIGN 52 Query: 69 YQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIAGKSV 128 Y++ ++I W G+R+ LRFD V V++N + + EH+GGY F ++T V G+ Sbjct: 53 YEKALYIRPEWKGKRLFLRFDGVNSIADVFINRKHIGEHRGGYGAFIFEITDLVKYGEKN 112 Query: 129 RITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVML------------ 176 + V NN +P DF Y GI+R V L Sbjct: 113 SVLVRANNGEQLDIMP---------------LVGDFNFYGGIYRDVHLLITDETCISPLD 157 Query: 177 YTTPNTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQ- 235 Y +P ++ V A+ C ++ A+G +++ D V + + +L+ Sbjct: 158 YASPGVYLVQEVVSPQEAKVCAKVNLS-NRAADGTAELQVLVTDGTKVICKESRNVSLKQ 216 Query: 236 -----------VVNPHLWQP-GEGYLYELCVTA-KSQTECDIYPLRVGIRSVAVKGE-QF 281 + P LW + ++Y++ ++ K + D +G+R + F Sbjct: 217 GADILEQLPLLIQKPRLWNGCEDPFMYQVSISLHKDGKQIDSVTQPLGLRYYHTDPDKGF 276 Query: 282 LINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWA 341 +N K G RH+D G D ALM +G N+ R +HYP A M D Sbjct: 277 FLNGKHLPLHGVCRHQDRAEVGNALRPQHHEEDVALMREMGVNAIRLAHYPQATYMYDLM 336 Query: 342 DEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKN 401 D+HGIV E VG GF ++ Q + ELI + N Sbjct: 337 DKHGIVTWAEIPFVGPGGYADKGFVDQAS-------------FRENGKQQLIELIRQHYN 383 Query: 402 HPSVVMWSIANEPDTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFD 461 HPS+ W + NE EY L ++ DPTRP T + + + + + Sbjct: 384 HPSICFWGLFNELKEVGDNPVEYVKELNALAKQEDPTRPTTSASNQDGNLNF-----ITE 438 Query: 462 VLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMW 521 + NRY GWY + K L + ++ H+ G+ S+Y Sbjct: 439 NIAWNRYDGWYGSTP----------KTLATFLDRTHKKHPELRIGISEYGAGASIYHQQD 488 Query: 522 S------------EEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATSQGI--LRVGGNK 567 S E +Q + ++ V G VWN DF + R G N Sbjct: 489 SLKQPSASGWWHPENWQTYYHMENWKIIAERPFVWGTFVWNMFDFGAAHRTEGDRPGIND 548 Query: 568 KGIFTRDRKPKSAAFLLQKR-WTGMN 592 KG+ T DRK + AF K W Sbjct: 549 KGLVTFDRKVRKDAFYFYKANWNKQE 574 >6D89-C nrPDB Length = 595 Score = 493 bits (1268), Expect = e-139, Method: Composition-based stats. Identities = 149/614 (24%), Positives = 252/614 (41%), Gaps = 79/614 (12%) Query: 10 REIKKLDGLWAFSLDRENCGIDQRWW------------ESALQESRAIAVPGSFNDQFAD 57 R+ LDG W +D G + + E + + + VPG +N Q Sbjct: 34 RQTTSLDGQWKTIVDPFENGRGMKVYQDKTYSDKTKLQEYDFETDKLLFVPGDWNTQ--R 91 Query: 58 ADIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEAD 117 + Y G VWY++ G+R+ L F AV + VW+N + + H GG+TPF + Sbjct: 92 PQLYYYEGTVWYRKHF-EYSLQPGKRLFLNFGAVNYEAIVWLNGKRLGRHIGGFTPFNFE 150 Query: 118 VTPYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLY 177 +T + G + V V+N+ + +P + D++N+ GI R V L Sbjct: 151 ITNLLKEGT-NSLVVKVDNKRLPEAVP--------------TVNADWWNFGGITRPVTLI 195 Query: 178 TTPNTWVDDITVVTHVAQDCNHASVDWQVVANGD------VSVELRDADQQVVATGQGTS 231 P T++ D V +A+D + W + D + + ++V G + Sbjct: 196 EMPATYIRDYYV--QLAKDDKNMIEGWVQLEGSDKEQKITLDIPELKVKKEVTTDANGYA 253 Query: 232 GTLQVVNPHLWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFT 291 L P LW P LY + + +++ D +G R++ +G + L+N K + Sbjct: 254 SFLIKSKPILWTPENPKLYAVNLASETDKVSDE----IGFRTIRTEGIKILLNDKEIFCR 309 Query: 292 GFGRHEDAD-LRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVID 350 G HE+ G+ + + +G N R +HYP+ EEM+ A+ G +V Sbjct: 310 GISIHEETPYYSGRAYSKDHAHTLLSWAKELGCNFVRLAHYPHNEEMVREAERMGFLVWS 369 Query: 351 ETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSI 410 E ++ N +T Q Q + ++IARDKN ++++WSI Sbjct: 370 EIPV-------------------YWTIHWENKDTYQNAEQQLCDMIARDKNRCNIIIWSI 410 Query: 411 ANEPDTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFC-----DAHTDTISDLFDVLCL 465 ANE + + + LA R LD R I D + +L D++ Sbjct: 411 ANE-TPHSKTRLTFLSNLANKARSLDSVRLIGAAMEKEEVQPGVLTVNDPLGELLDIISF 469 Query: 466 NRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEY 525 N Y GWY GD E ++V W +P+ I+E G L G H + ++EEY Sbjct: 470 NEYVGWY--DGDSEKCDRV------NWTFDTQKPVFISELGGGALYGHHGSPKERFTEEY 521 Query: 526 QCAWLDMYHRVFDRVSAVVGEQVWNFADFATSQ---GILRVGGNKKGIFTRDRKPKSAAF 582 Q + + R+ + G W DF + + ++ N+KG+ + + K A F Sbjct: 522 QEDLYIRHVNMLKRIPGLAGTTPWILKDFRSPRRHVPEIQDDFNRKGLVSDKGQKKKAFF 581 Query: 583 LLQKRWTGMNFGEK 596 +LQK + + K Sbjct: 582 VLQKWYKELTEAYK 595 >6NCZ-A nrPDB Length = 610 Score = 488 bits (1255), Expect = e-138, Method: Composition-based stats. Identities = 144/614 (23%), Positives = 262/614 (42%), Gaps = 83/614 (13%) Query: 10 REIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVP--GSFND----------QFAD 57 R + L+G W +++D+ + + Q+W++ ++ + VP SF++ D Sbjct: 38 RREELLNGGWHYAVDQYDTCLRQKWYKERYRDEKGFTVPIDYSFDEWPVMQLPCSWNTID 97 Query: 58 ADIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEAD 117 Y G++ + R+ + + L+ A + +V++N + V H+GG TP + Sbjct: 98 PMYLLYEGSMVFTRKFS-YIAEREETVFLKVGAANYLCRVFLNGKYVGMHRGGSTPAFWN 156 Query: 118 VTPYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLY 177 +T Y+ A RI + V+ + +P + D+FNY G++R + L Sbjct: 157 ITEYLKA--ENRIVLAVDGTRRPEQVP--------------TENTDWFNYCGVYRDIALI 200 Query: 178 TTPNTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVV 237 P + + + D V +V + ++ A ++V G S +Q+ Sbjct: 201 RVPKCHIKTFKIA--LVPDGTFGHVMAKVTLSEKIT-----AKAELVIEELGVSRKIQLE 253 Query: 238 N----------PHLWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKP 287 N P LW P + LY++ VT + T D RVG R + V G L+N +P Sbjct: 254 NGAGEVVFDAKPELWTPEKPKLYDVKVTCGTDTVSD----RVGFREIRVNGRDILLNGEP 309 Query: 288 FYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIV 347 + G HED+ GKG + + + +G N R +HYP+ EEM ADE G++ Sbjct: 310 VFLRGISCHEDSVENGKGLTREERIENIRIAKELGCNFMRLAHYPHNEEMAKLADELGLL 369 Query: 348 VIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVM 407 + +E ++ +T + ++ELI RD N SV++ Sbjct: 370 LWEEIPV-------------------YWAIRFEREKTYEDAQNQLRELINRDWNRASVII 410 Query: 408 WSIANEPDTRPQGAREYFAPLAEATRKLDPTRPITCVN--VMFCDAHTDTISDLFDVLCL 465 WS+ NE + + + + LAE + D TR ++ + D + + D++ + Sbjct: 411 WSVGNENADTDERLK-FMSVLAECAHREDETRMVSAACLVNAAKNKIEDRLMEYLDIIGI 469 Query: 466 NRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEY 525 N Y GWY + D ++E + +P+I+TE+G D L H +D +EE Sbjct: 470 NEYCGWY--TPDFAMLPALME------NSQPDKPVIVTEFGADALPHHHGTISDKGTEEC 521 Query: 526 QCAWLDMYHRVFDRVSAVVGEQVWNFADFATSQ--GILRVGGNKKGIFTRDRKPKSAAFL 583 Q + + + G W DF + +++ N+KG+ + D+K + AF Sbjct: 522 QADVYEKQIATLRNIDYIKGMTPWILYDFRCPRRTSLIQKYYNRKGLLSEDKKYRKPAFY 581 Query: 584 -LQKRWTGMNFGEK 596 LQK + + E+ Sbjct: 582 VLQKFYEELKRKEQ 595 >6D8K-A nrPDB Length = 597 Score = 482 bits (1240), Expect = e-136, Method: Composition-based stats. Identities = 158/617 (25%), Positives = 266/617 (43%), Gaps = 83/617 (13%) Query: 10 REIKKLDGLWAFSLDRENCGIDQR------------WWESALQESRAIAVPGSFNDQFAD 57 R+I+ L+G W +D + G + ++E + Q + VPG +N Q Sbjct: 33 RDIRSLNGKWNAIIDLYDQGRGMKVYRNQSPKGNTDFYEYSFQGGLRLNVPGDWNSQT-- 90 Query: 58 ADIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEAD 117 +++ Y G VWY R K +R L F AV++ +V++N E+ H+GG+TPF+ + Sbjct: 91 PELKYYEGTVWYARHFD-AKRLTHKRQFLYFGAVSYRCRVYLNGAEIGSHEGGFTPFQIE 149 Query: 118 VTPYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLY 177 VT + G++ I + VNN IP D++NY GI R V+L Sbjct: 150 VTDLLNEGENF-IAIEVNNRRTKDAIPA--------------MSFDWWNYGGITRDVLLV 194 Query: 178 TTPNTWVDDITV-VTHVAQDCNHASVDWQVVANGD---VSVELRDADQQVVATGQGTSGT 233 TTP T+++D + + + + A V G+ VS+ ++ +G + T Sbjct: 195 TTPQTYLEDYFIQLDKESPNRMIAKVALSDKKAGEKITVSIPELKTSIDMLTDAEGKAET 254 Query: 234 L-QVVNPHLWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTG 292 + + W LYE+ V++ + D ++G R++ VKG +N KP + Sbjct: 255 VFNIKKLERWSSENPKLYEVIVSSAN----DRVEEQIGFRNITVKGTDIYLNGKPTFMCS 310 Query: 293 FGRHEDADLR-GKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDE 351 HE+ R G+ F +G N R +HYP E + A++ G ++ E Sbjct: 311 ISFHEEIPQRMGRAFSEADAAMLLNEAKALGVNMIRLAHYPQNEYTVRLAEKMGFILWQE 370 Query: 352 TAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIA 411 + N T++ + + E+I RD+N +V W IA Sbjct: 371 IPVWQ-------------------GIDFTNNNTRKKAQRMLSEMIKRDQNRCAVGYWGIA 411 Query: 412 NEPDTRPQGAR-EYFAPLAEATRKLDPTR-PITCVNVMFCDAH------TDTISDLFDVL 463 NE T+P AR E+ L E ++LD TR + +++ + D+ + DV+ Sbjct: 412 NE--TQPSKARNEFLTSLLETGKQLDTTRLYVAAFDLVRFNREKKRFVMEDSFTSQLDVV 469 Query: 464 CLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTD--MW 521 +N+Y GWY +E E W+ +P+II+E+G + L G W Sbjct: 470 AVNKYMGWYH--------PWPIEPENAVWEVIPDKPLIISEFGGEALYGQSGDENVASSW 521 Query: 522 SEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATS---QGILRVGGNKKGIFTRDRKPK 578 SEEYQ R+FD + + G W DF + + G N+KG+ + D+ + Sbjct: 522 SEEYQARLYRDNIRMFDNIPNLRGVSPWILFDFRSPFRFHPTNQDGWNRKGLVS-DQGIR 580 Query: 579 SAAFLLQKRWTGMNFGE 595 A+ L + + FGE Sbjct: 581 KKAWYLMREYYKTKFGE 597 >6D1P-A nrPDB Length = 814 Score = 475 bits (1223), Expect = e-134, Method: Composition-based stats. Identities = 138/651 (21%), Positives = 225/651 (34%), Gaps = 115/651 (17%) Query: 2 LRPVETPTREI-------KKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQ 54 L P + R + + +W G + L + + +P FN + Sbjct: 22 LIPTDRKQRLTEHWEFIRQDMGSIWEVMRPITGAGKPE---TVPLW--QKVTLPHCFNAE 76 Query: 55 FA-DADIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTP 113 A D D+ Y G WY+ + I + R L F+ +V+V + H GGY Sbjct: 77 DAVDPDVNYYQGPGWYRTMLNIENPYTNGRTCLEFEGAGQKTEVYVYTTRIASHVGGYDE 136 Query: 114 FEADVTPYV-----------IAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFH 162 ++AD+T V G + I + +N + + IP M Sbjct: 137 WKADITEAVEAFRRTPLCRERFGGKIPIAIRCDNSRDTEMIPSDMS-------------- 182 Query: 163 DFFNYAGIHRSVMLYTTPNTWVDDITVVTHVAQDCNHASVDWQVVANG---------DVS 213 DF Y G++R V L TP + I + + S+ + G + S Sbjct: 183 DFNLYGGLYRYVNLVYTPAVHFEQIRIEATTDEKGKQGSISIDIAFGGLSGKEKKAKEFS 242 Query: 214 VELRDADQQVV-----ATGQGTSGTLQVVNPHLWQPGEGYLYELCVTAKSQTECDIYPLR 268 + + + + V + +S + + P LW P LY + Sbjct: 243 LRVFSPEGKEVNSISSELTEISSYQISLKRPQLWSPHSPALYTCVAELIDNGDTLRTTQH 302 Query: 269 VGIRSVAVKGEQ-FLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYR 327 G R + + F +N + G RHED G +M + + +GAN R Sbjct: 303 FGFRHFRFEEKGPFYLNGERLLLRGTHRHEDHAGVGAALTEEMMRTEMQQIKEMGANFIR 362 Query: 328 TSHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQA 387 HY + +L DE G++V +E + G E Y +A Sbjct: 363 LGHYQQSGIILRLCDELGLLVWEEIP-----------WCRGGLGGESYKNQA-------- 403 Query: 388 HLQAIKELIARDKNHPSVVMWSIANEPDT-------RPQGAREYFAPLAEATRKLDPTRP 440 + + +I + +NHPSV++W + NE D R + L + +LDPTR Sbjct: 404 -RRMLTNMIEQHRNHPSVILWGLGNENDWPGDFQTFEKDSIRAFMGELHDLAHRLDPTRS 462 Query: 441 ITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPI 500 FC D+ DV + GWY ++ + A LH Sbjct: 463 TAIRRCEFCK-------DIVDVYSPTIWAGWY--GRRFRNYREMETAGINATTRFLH--- 510 Query: 501 IITEYGVDTLAGLHSMYTDM-------------------WSEEYQCAWLDMYHRVFDRVS 541 E+G D+ AG H WSE Y D + + + + Sbjct: 511 --AEWGGDSHAGRHMEVNKETGRKGIDNFDIEAADRNGDWSESYIIRLFDWHLKEQETMP 568 Query: 542 AVVGEQVWNFADFATSQGILR--VGGNKKGIFTRDRKPKSAAFLLQKRWTG 590 + G W F DF+T N+KG+ RD PK + ++ Q W+ Sbjct: 569 RLTGSLFWTFKDFSTPLRPDNPIPYVNQKGVVQRDGTPKESYYVFQSYWSS 619 >6MVF-A nrPDB Length = 769 Score = 475 bits (1222), Expect = e-134, Method: Composition-based stats. Identities = 152/618 (24%), Positives = 235/618 (38%), Gaps = 91/618 (14%) Query: 2 LRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQF-ADADI 60 L REI L+ W + + + +P ++N D + Sbjct: 17 LYFQSNAMREIISLNEGWTLRFPKGERAAE------------TVTLPHTWNAVDGMDGNG 64 Query: 61 RNYAGNVWYQREVFIP-KGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVT 119 Y R P + G R+ + A V VN H+GG++ F AD+T Sbjct: 65 SYLRTTGVYSRTFKKPVQPLTGGRVYVEVLAAALDATVKVNGTVATTHEGGFSIFRADIT 124 Query: 120 PYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTT 179 G +T+ V+NE P DF Y G++R V L + Sbjct: 125 DLCRDGD-NELTIEVSNEDTPSMYPASA---------------DFTFYGGLYRGVNLISV 168 Query: 180 PNTWVD-------DITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQ--------VV 224 PN D I V D V N D S + + + V Sbjct: 169 PNAHFDLDYYGGPGIMVTPKPTADGGATFEIKSFVTNPDDSFTVMYSIEDPYGCEVASAV 228 Query: 225 ATGQGTSGTLQVVNPHLWQPGEGYLYELCVTAKSQTEC-DIYPLRVGIRSVAVKGEQ-FL 282 T+ ++ V + LW E LY + + E D VG+RS V + F Sbjct: 229 RPSDNTAISIYVPDAELWSMDEPNLYTVVARLQRNNEAFDEIYANVGVRSYTVTPDGGFS 288 Query: 283 INHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWAD 342 IN + G RH+D +G D ++ +GAN+ R +HY ++++ D D Sbjct: 289 INGEATPLRGVSRHQDKLYKGNALTVEDHYQDAQIIKELGANTIRLAHYQHSQDFYDACD 348 Query: 343 EHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNH 402 E G V E + F++G EE +KELI ++ NH Sbjct: 349 ELGFAVWAEIPFISV-------FKSGKDAHTHVMEE-------------MKELIIQNYNH 388 Query: 403 PSVVMWSIANE--PDTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLF 460 PS++ W I+NE Q + L + ++LDPTR T +V + + + Sbjct: 389 PSILFWGISNEILIGGISQELVDTHHDLQKLCKELDPTRLTTIAHVSH-TPTSGPMHRIT 447 Query: 461 DVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLH--QPII---ITEYGVDTLAGLHS 515 DV N Y+GWY G +E + W +K H P I I+EYG + + HS Sbjct: 448 DVESYNHYFGWY--GGKIE--------QNGPWLDKFHAENPDICLGISEYGCEGIINWHS 497 Query: 516 MYTDM--WSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADF---ATSQGILRVGGNKKGI 570 +SEEYQ + + + F+ + VWN DF A S+G ++ G N KG+ Sbjct: 498 NTPQCKDYSEEYQALYHEYMAQAFEDRPWIWASHVWNMFDFGCAARSEGGVK-GRNNKGL 556 Query: 571 FTRDRKPKSAAFLLQKRW 588 T DRK + +F + + + Sbjct: 557 VTIDRKTRKDSFYVYQAY 574 >6NCW-A nrPDB Length = 574 Score = 458 bits (1177), Expect = e-129, Method: Composition-based stats. Identities = 157/600 (26%), Positives = 231/600 (38%), Gaps = 73/600 (12%) Query: 10 REIKKLD-GLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADIRNYAGNVW 68 R+ +L LW F I + E+ +Q VPG + + D +Y G Sbjct: 11 RKTAELSSALWNFHT------IGTQGEEAVIQA----PVPGCWENY---PDTVSYRGQAS 57 Query: 69 YQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIAGKSV 128 Y RE A I L F V+H V V+ + V H YTPF+ + G Sbjct: 58 YSREF-----EAKGNIRLEFKGVSHTASVLVDGKPVGSHYNAYTPFDVVLKDI-RPG-IH 110 Query: 129 RITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNTWVDDIT 188 ++ V +N + +D+ +Y GI R V+L ++ I Sbjct: 111 QLEVIADNSFGPDS--------------ALHVPNDYQSYGGISRGVVLEELGEAYLSWIH 156 Query: 189 VVTHVAQDCNHASVDWQVV------ANGDVSVELRD---ADQQVVATGQ--GTSGTLQVV 237 + +D + + V +G V VE+ A +V G+ + T ++ Sbjct: 157 FTPFLRKDGWYGKAEICVRNLSSGRLDGSVEVEIGKNSFAVLPIVLEGEEEKSFSTEELP 216 Query: 238 NP--HLWQPGEGYLYEL-CVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFG 294 P W P LY + V + D RVG R + +G+ L+N + GF Sbjct: 217 CPWAECWSPESPVLYLITAVLRTADGAADDIIDRVGFREIRTEGKDILLNGRKLRIKGFC 276 Query: 295 RHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAA 354 RHED G M HD L+ +GANS RT HYP E LD DE GI+V +E A Sbjct: 277 RHEDHPQFGCALPFSAMQHDLMLIKDLGANSIRTVHYPNDELFLDLCDEQGILVWEENHA 336 Query: 355 VGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEP 414 G L E N +Q I+E+I NHPS+ +W I NE Sbjct: 337 RG-----------------LSEENMRNPHFKQQCGDCIREMITAHYNHPSIYIWGILNEC 379 Query: 415 DTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQ 474 + + RE ++ E + LDP RP + + C TD +V+ N Y WY Sbjct: 380 ASDTEYGRECYSEQYELIKSLDPYRPRSSAS---CRFKTDICLGYPEVVSYNIYPKWYHD 436 Query: 475 SGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYH 534 +E L + + E +P +ITE G + G + WSEEYQ L Sbjct: 437 VP-VEDYLDELYQWIQNESEGTGKPFLITEIGAGAIYGYRTPAHVKWSEEYQVQALKEQL 495 Query: 535 RVFDRVSAVVGEQVWNFADFATSQ---GILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGM 591 + G +W F D G N KGI R+PK A +++ + + Sbjct: 496 QAVFSREGCSGVYIWQFCDVRVCDSWFGSRPRTMNNKGIVDEYRRPKLAYEVVKDSYRSL 555 >6DXU-D nrPDB Length = 830 Score = 451 bits (1161), Expect = e-127, Method: Composition-based stats. Identities = 144/641 (22%), Positives = 237/641 (36%), Gaps = 113/641 (17%) Query: 14 KLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFA-DADIRNYAGNVWYQRE 72 L G+W + + + + +P FN + A D D+ Y G WY+ Sbjct: 43 DLGGIW----EAVRPAAPGSSEAVPIW--QPVTLPHCFNAEDAVDPDVNYYEGPGWYKTL 96 Query: 73 VFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVI--------- 123 + I + RIVL FD V+V V H GGY + D+T V Sbjct: 97 LAIDNPYRNGRIVLDFDGAGQKTDVYVYTTHVGSHVGGYDSWNVDITDAVKAFLGSKDAE 156 Query: 124 -AGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNT 182 V +++ +N + + IP + DF Y G++R + L P Sbjct: 157 RFKGKVPLSIRCDNSRDLEMIPSDLA--------------DFNIYGGLYRYLNLVYLPEV 202 Query: 183 WVDDITVVTHVAQDCNHASVDW-------QVVANGDVSVELRDADQQVV---------AT 226 + I + + ++ + + + + DV+V + D D++ V Sbjct: 203 SFEQIHLESSLSSNLKEGILKVKTSFYNPEDIRKADVTVSVYDVDRKPVFSKTLEGILPL 262 Query: 227 GQGTSGTLQVVNPHLWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQ-FLINH 285 G +++ NP LW LY +T K+ + R G R K + F +N Sbjct: 263 GDQLLAKMKIKNPVLWDVDVPQLYTCELTVKTPDQTFTTEERFGFRHTEFKDKGPFFLNG 322 Query: 286 KPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHG 345 K G RHED + +M + +M +G N R HY +E +LD DE G Sbjct: 323 KRLLLRGTHRHEDHAGVAQAMTEDMMRREMRMMKDMGVNFIRLGHYQQSEIILDLCDELG 382 Query: 346 IVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSV 405 I+V +E + G ++Y ++A + + +I + NHP+V Sbjct: 383 ILVWEEIP-----------WCRGGLGGDVYKKQA---------RRMLANMIVQHHNHPAV 422 Query: 406 VMWSIANEPDTRPQ-------GAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISD 458 ++W + NE D R + L + +LD TR FC+ D Sbjct: 423 IIWGLGNENDWPNDFNTFDKSAIRAFMKELHDMAHRLDDTRMTAIRRCEFCN-------D 475 Query: 459 LFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQ-------------------P 499 + DV + + GWY G + + E+E+ + LH Sbjct: 476 IVDVYSPSIWAGWY--RGVFTDYKSISEQEMQKVKHFLHVEWGGDSHARRHSEDAFYNLK 533 Query: 500 IIITEYGVDTLAGLHSMYTDM--------WSEEYQCAWLDMYHRVFDRVSAVVGEQVWNF 551 I G D AG S+Y + WSE Y +D + + + + + G W F Sbjct: 534 NIEAGKGGDERAGDASLYGGVPRASRDGDWSESYVVRLIDWHLKEQETMPWLTGTAYWPF 593 Query: 552 ADFATSQGILR--VGGNKKGIFTRDRKPKSAAFLLQKRWTG 590 DF+T N+KG+ RD PK + ++ Q WT Sbjct: 594 KDFSTPVRPDNPVPYVNQKGVVERDFTPKESYYVFQSYWTE 634 >3FN9-A nrPDB Length = 692 Score = 449 bits (1155), Expect = e-126, Method: Composition-based stats. Identities = 142/636 (22%), Positives = 236/636 (37%), Gaps = 105/636 (16%) Query: 10 REIKKLDGLWAFSLDRE-NCGIDQRWWESALQESRAIAVPGSFNDQF-ADADIRNYAGNV 67 R++ + W F + E+ + +P ++N Y G Sbjct: 5 RQVTAFNTGWQFKKGPFATDPMRAASQWDGKWET--VEIPHTWNAMDMQVQSGSFYEGAG 62 Query: 68 WYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIAGKS 127 +Y++ F P G+R+ LRF+ V +V+VN + H+GGY+ F ++ + G Sbjct: 63 YYRKTQFFPHDLEGKRVFLRFEGVGACAEVYVNGKLAGTHKGGYSAFACEIGTALKLGAE 122 Query: 128 VRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTT-------- 179 I V +N+ IP + F Y GI+R V L T Sbjct: 123 NEIIVKADNKARPDVIPVNQNL--------------FGVYGGIYRPVWLIVTEQNNITVT 168 Query: 180 ----PNTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVE--LRDADQQVVAT------- 226 P ++ V A +D + V++E + + Q V T Sbjct: 169 DCASPGVYITQKDVSKKSADITVKVKLDNAGLQPAAVTLENTIYTQEGQKVGTHSRSFDL 228 Query: 227 ----GQGTSGTLQVVNPHLWQP-GEGYLYE-LCVTAKSQTECDIYPLRVGIRSVA-VKGE 279 Q T ++ NPHLWQ + YLY+ +C D +G+R V G+ Sbjct: 229 SPQGTQTYLSTFKLKNPHLWQGRKDPYLYKVVCRLMADGKVIDEVVQPLGVRKYEIVAGK 288 Query: 280 QFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLD 339 F +N + + G RH+D G N D A + +GA + R +HY ++ + Sbjct: 289 GFFLNGEKYSMYGVTRHQDWWGLGSALKNEHHDFDLAAIMDVGATTVRFAHYQQSDYLYS 348 Query: 340 WADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARD 399 D G+++ E V V G + ++ELI + Sbjct: 349 RCDTLGLIIWAEIPCV----------------------NRVTGYETENAQSQLRELIRQS 386 Query: 400 KNHPSVVMWSIANEPDTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDL 459 NHPS+ +W + NE + L + + DP R VN H D +L Sbjct: 387 FNHPSIYVWGLHNEVYQPHEYTAALTRSLHDLAKTEDPDRYTVSVNGY---GHMDHPVNL 443 Query: 460 -FDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEK-----LHQPIIITEYGVDTLAGL 513 D+ +NRY+GWY + +++ W E+ +Q +++TEYG D Sbjct: 444 NADIQGMNRYFGWY----------EKKIQDIKPWVEQLEKDYPYQKLMLTEYGADANLAH 493 Query: 514 HSMY--------TDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATSQGILRVGG 565 + Y + E +Q + + ++ +WN DFA + GG Sbjct: 494 QTEYLGDALNWGKPFYPETFQTKTHEYQWSIIKDHPYIIASYLWNMFDFAVP--MWTRGG 551 Query: 566 ----NKKGIFTRDRKPKSAAFLLQKRWTGMNFGEKP 597 N KG+ T DRK K ++ W N+ E+P Sbjct: 552 VPARNMKGLITFDRKTKKDSYF----WYKANWSEEP 583 >5T99-A nrPDB Length = 822 Score = 438 bits (1127), Expect = e-123, Method: Composition-based stats. Identities = 134/605 (22%), Positives = 223/605 (36%), Gaps = 50/605 (8%) Query: 13 KKLDGLWAFSLDRENCGI-----DQRWWESALQESRAIAVPGSFNDQFADADIRNYAGNV 67 + W F D W + L AI P + A + G Sbjct: 28 ISFNENWRFFKGEIKGAEAISFDDDSWRKLNLPHDWAIEGPFD-SKYNARCGGLPFHGTG 86 Query: 68 WYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIAGKS 127 WY++ W + + + FD KVW+N +V EH GYT FE D+T Y+ G+ Sbjct: 87 WYRKTFIGDAQWKDKIVRIGFDGAMSEAKVWINGVKVGEHPYGYTGFEIDITKYLKIGEE 146 Query: 128 VRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNTWVDDI 187 + V + PG I + + + G++ + T V Sbjct: 147 NVLAVQLTPRDLSSRWYPGAGIYRNVWLRVDNKV--YIPEHGVYVTTPTVTKSKAVVQIE 204 Query: 188 TVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTS-GTLQVVNPHLWQPGE 246 T V + ++ ++ +V + + + +V A QG + + ++NP++W Sbjct: 205 TTVKNATFGNGKFNIRHSIINAQGETVAILNDNVEVAAGEQGKTLAYINMLNPNIWGQKN 264 Query: 247 GYLYELCVTAKSQTE-CDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHEDADLRGKG 305 Y+Y+L + D Y GIR + + F +N + F G H D G Sbjct: 265 PYMYKLKTEIYDGKDLTDTYFTDFGIRKICFTKDGFFLNGEKIRFNGVCLHHDNGPMGAA 324 Query: 306 FDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGF 365 + +M +G N+ RTSH P + E LD D G+VV+DE + G+ Sbjct: 325 VNVRADERKLQIMKEMGVNAIRTSHNPPSPEFLDLCDRMGLVVLDEAFDEWTKAKVDNGY 384 Query: 366 EAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQGAREYF 425 LY +E + + LI RD+NHPSV+MWSI NE + + + Sbjct: 385 -------HLYFDEWS--------KKDLTSLIMRDRNHPSVIMWSIGNEILEQSDKKKGFT 429 Query: 426 --APLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEK 483 LA+ R+LDPTRP TC + + ++ D+ +N G Y + L Sbjct: 430 VAKYLADICRELDPTRPSTCGFNYYPAPFDNNMAQQVDIAGMNYKPGKYAEVQRLYPDLP 489 Query: 484 VLEKELLAWQEK---LHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRV 540 + E + H PI E + + W+ Y ++ + + + Sbjct: 490 LYGSETSSCTSSRGVYHLPIEKYEKNGTNQVTSYDLIGPKWA--YPPD-IEFHFQEMN-- 544 Query: 541 SAVVGEQVWNFADF-----------ATSQGILRVGGNKK----GIFTRDRKPKSAAFLLQ 585 +GE +W D+ ++ G + G PK +L Q Sbjct: 545 PRFMGEFIWTGFDYLGEPTPYGGRDNSTHGYWNDDWPSRSSYFGAVDLCGLPKDRFYLYQ 604 Query: 586 KRWTG 590 +WT Sbjct: 605 SQWTD 609 >6B6L-A nrPDB Length = 776 Score = 380 bits (976), Expect = e-106, Method: Composition-based stats. Identities = 136/583 (23%), Positives = 205/583 (35%), Gaps = 107/583 (18%) Query: 6 ETPTREIKKLDGLWAFSLDRENCGI-----DQRWWESALQESRAI-AVPGSFNDQFADAD 59 T + D W F G D +W + L +I +PG+ + ADA Sbjct: 1 SNATLREQSFDEAWLFHRGDIAEGEKQSLDDSQWRQINLPHDWSIEDIPGTNSPFTADAA 60 Query: 60 IR-----NYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPF 114 G WY++ +I G+ I + FD + +WVN++ V H GYT F Sbjct: 61 TEVAGGFTVGGTGWYRKHFYIDAAEKGKCIAVSFDGIYMNADIWVNDRHVANHVYGYTAF 120 Query: 115 EADVTPYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSV 174 E D+T YV G I V V NE ++ +GI+R Sbjct: 121 ELDITDYVRFGAENLIAVRVKNE---------------------GMNCRWYTGSGIYRHT 159 Query: 175 MLYTTPNTWVDDI-TVVTHVAQDCNHASVDWQ--------VVANGDVSVELRDADQQVVA 225 L T + T VT + A V Q V + + D + VA Sbjct: 160 FLKITNPLHFETWGTFVTTPVATADKAEVHVQSVLANTEKVTGKVILETRIVDKNNHTVA 219 Query: 226 TGQG-----------TSGTLQVVNPHLWQPGEGYLYELC-VTAKSQTECDIYPLRVGIRS 273 + L+V+ P LW YLY++ + D + +GIR+ Sbjct: 220 RKEQLVTLDNKEKTEVGHALEVLAPQLWSIDNPYLYQVVNRLLQDDKVIDEEYISIGIRN 279 Query: 274 VAVKGE-QFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYP 332 +A E F +N K G H D L G + L+ G N+ R SH P Sbjct: 280 IAFSAENGFQLNGKSMKLKGGCIHHDNGLLGAKAFDRAEERKIELLKAAGFNALRLSHNP 339 Query: 333 YAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAI 392 + +L+ D G++VIDE + ++ +L+ E + Sbjct: 340 PSIALLNACDRLGMLVIDEAFDMW--RYGHYQYDYAQYFDKLWKE-------------DL 384 Query: 393 KELIARDKNHPSVVMWSIANEPDTRPQGA-REYFAPLAEATRKLDPTRPITCVNVMFCDA 451 ++ARD+NHPSV+MWSI NE + + L + LD TRP+T DA Sbjct: 385 HSMVARDRNHPSVIMWSIGNEIKNKETAEIVDICRELTGFVKTLDTTRPVTAGVNSIVDA 444 Query: 452 HTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLA 511 D ++ L DV N Y ++ A Sbjct: 445 TDDFLAPL-DVCGYNYCLNRY-----------------------------------ESDA 468 Query: 512 GLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADF 554 H SE Y D Y + + S V+G+ +W D+ Sbjct: 469 KRHPDRIIYASESYASQAYD-YWKGVEDHSWVIGDFIWTAFDY 510 >3GM8-A nrPDB Length = 801 Score = 378 bits (970), Expect = e-105, Method: Composition-based stats. Identities = 136/653 (20%), Positives = 220/653 (33%), Gaps = 123/653 (18%) Query: 11 EIKKLDGLWAFSLDRENCGI------DQRWWESALQESRAIAVPGSFNDQFADADIRNY- 63 E W F L G D +W + +I + D Sbjct: 5 ETINFCKGWKFHLGDAGKGASSSSYNDSQWRILNIPHDWSIEGTYKQFENGTDWQSGFLP 64 Query: 64 AGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVI 123 AG WY++ IP W +++ + F+ V +VW+N + + GY F D+TPY+ Sbjct: 65 AGISWYRKTFTIPSKWKNKKVQILFEGVYLNSEVWINGHWLGKRPNGYISFVYDLTPYLQ 124 Query: 124 AGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNTW 183 GK +I V V++ ++ +GI+R V L + T Sbjct: 125 EGK-NQIAVKVDHSKALT--------------------GRWYTGSGIYRPVYLLVSNPTH 163 Query: 184 V--DDITVVTHVAQDCN---HASVDWQVVANGDVSVELR---------DADQQVVATGQG 229 + I + + + S++ + + V+ D +++ + Sbjct: 164 IPYSGIHFRSKLQNKQSATYTLSIEIETQEKKPIKVKTYLQAPNGSIADTSEKIFVSSAD 223 Query: 230 TSGTLQ--VVNPHLWQPGEGYLYEL-CVTAKSQTECDIYPLRVGIRSVAVKG-EQFLINH 285 + L + P LW P +Y L C + D L VG R + FL+N Sbjct: 224 SLCFLSGSIRKPLLWSPDSPNVYTLICQLTRDNKILDECRLPVGFRQLEFNPVSGFLLNG 283 Query: 286 KPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHG 345 K G H G + L+ + L+ +G N+ RTSH P++ + D G Sbjct: 284 KSLKIKGVCDHHTVGAVGAAVPDDLLHYRLKLLKDMGCNAIRTSHNPFSPAFYNLCDTMG 343 Query: 346 IVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSV 405 I+V++E G + N+PK E Q + + + I RD+NHPS+ Sbjct: 344 IMVLNE------------GLDGWNQPKAADDYGNYFDEWWQ---KDMTDFIKRDRNHPSI 388 Query: 406 VMWSIANEPDTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTIS---DLFDV 462 +MWSI NE E L +LDP RP+T + D+ Sbjct: 389 IMWSIGNEVTG---ATPEIQHNLVSLFHQLDPDRPVTQGGTDPTRGMKTDYQKKFNYLDI 445 Query: 463 LCLN--------------RYY----------------GWYVQSGDL--ETAEKVLEKELL 490 + N Y G Y EK + Sbjct: 446 IGFNGNGEEIGELEHFHKNYPTLCAIATEVPHTYQTRGVYRSQTQWRRRDFPAPWEKGNI 505 Query: 491 AWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEE-----YQCAWLDMYHRVFDR------ 539 W++ H+ I + + + EE YQ ++ + R+ R Sbjct: 506 NWEQFKHRVFPIPDL----------TEKECFPEESDYPYYQSSYDNASVRISARKSWQRT 555 Query: 540 --VSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTG 590 ++GE W D+ + GN GI PK A FL Q WT Sbjct: 556 CSFPWLMGEFRWGSFDYLGEAEWPQRCGNF-GIIDIAAIPKDAYFLYQSLWTD 607 >4YPJ-A nrPDB Length = 810 Score = 375 bits (964), Expect = e-104, Method: Composition-based stats. Identities = 130/636 (20%), Positives = 224/636 (35%), Gaps = 104/636 (16%) Query: 14 KLDGLWAFS-------LDRENCGID-QRWWESALQESRAIAVPGSFNDQFADADIRNYAG 65 + W F +N G D W + L +I + + N G Sbjct: 11 NFNENWRFQRETNGSIAGAQNPGFDDSSWRKLNLPHDWSIELDFNKNSLATHEGGYLDGG 70 Query: 66 NVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYV-IA 124 WY++ IP+ G+RI L FD V ++N + + + GY F D++ + Sbjct: 71 IGWYRKTFTIPESMKGKRISLDFDGVYMNSTTYLNGEVLGTYPFGYNAFSYDISDKLYKD 130 Query: 125 GKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNTWV 184 G++ + V VNN T P +++ +GI+R+V L T V Sbjct: 131 GRANVLVVKVNN-----TQPSSR----------------WYSGSGIYRNVYLTVTDPIHV 169 Query: 185 D--------------------DITVVTHVAQDCNHAS---VDWQVVANGDVSVELRDADQ 221 D+ + T ++ D A + + +V+ + ++ Sbjct: 170 ARYGTFVTTPNLEKSIKEDRADVNIKTKISNDAAEAKQVKIKSTIYDGAGNTVQTVETEE 229 Query: 222 QVVATGQGTSGTLQ--VVNPHLWQPGEGYLYELCVTA-KSQTECDIYPLRVGIRSVAVK- 277 + A G T + P LW + Y Y L D Y + G+R Sbjct: 230 KTAAAGTVTPFEQNTVIKQPKLWSIDKPYRYNLVTEVIVGGQTVDTYETKFGVRYFKFDE 289 Query: 278 GEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEM 337 E F +N + G H D G + + +M +G N+ R +H P + E+ Sbjct: 290 NEGFSLNGEYMKLHGVSMHHDLGALGAATNARGVERQMQIMKDMGVNAIRVTHNPASPEL 349 Query: 338 LDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIA 397 L+ A++ G+ +I+E F++ + K+ Y + IKE++ Sbjct: 350 LEAANKLGLFIIEE------------AFDSWAQSKKPYDYGRFFNAWAEH---DIKEMVD 394 Query: 398 RDKNHPSVVMWSIANEP-DTRPQGAREYFAPLAEATRKLDPTRPITC---------VNVM 447 R KN P+++MWSI NE DT E L +++D TRP T VNV Sbjct: 395 RGKNEPAIIMWSIGNEIYDTTNAAGVETARNLVGWVKEIDTTRPTTIGEDKTRGDKVNVT 454 Query: 448 FCDAHTDTISDLFDVLCLNR----YYGWYVQSG--DLETAEKVLEKELLAWQEKLHQPII 501 +++ I ++ DV+ LN Y G++ Q+ L +E +Q Sbjct: 455 PINSYIKEIFNIVDVVGLNYSENNYDGYHKQNPSWKLYGSETSSATRSRGVYTHPYQYNQ 514 Query: 502 ITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATSQGIL 561 T+Y D + W + + + + G+ +W D+ G Sbjct: 515 STKY-ADLQQSSYDNDYVGWG-----RTAEDAWKYDRDLKHIAGQFIWTGFDY---IGEP 565 Query: 562 RVGGNKK-------GIFTRDRKPKSAAFLLQKRWTG 590 N G PK + Q +W Sbjct: 566 TPYYNSYPAKSSYFGAVDTAGFPKDIFYYYQSQWKK 601 >5EUV-A nrPDB Length = 731 Score = 372 bits (955), Expect = e-103, Method: Composition-based stats. Identities = 140/583 (24%), Positives = 220/583 (37%), Gaps = 67/583 (11%) Query: 10 REIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADIRNYAGNVWY 69 R +KL+ W F+ + L A+ +P S+ D+ + Y Y Sbjct: 2 RVTQKLNHGWIFAEGAADPATPLAGETVTLPH-NAVDLPLSYFDETS------YQRAFTY 54 Query: 70 QREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIAGKSVR 129 QR + W G+R+ LRFD VWVN +V+ H GYTPF AD+T ++ G ++ Sbjct: 55 QRVIAWDDAWQGRRVQLRFDGAMADNVVWVNGVQVVAHPDGYTPFVADLTDHLRPGDNL- 113 Query: 130 ITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNTWVDDITV 189 +TV ++ N P G I D+ YAGI+R V L P + + + Sbjct: 114 VTVRIDGSENPAIPPFGAQI-------------DYLTYAGIYRDVWLMVLPERHLTNARI 160 Query: 190 VTHVA-QDCNHASVDWQVVANGDVSVELRDADQQVVA-TGQGTSGTLQVVNPHLWQPGEG 247 +T A D + +V A G V L D D+++ A G+G + LW Sbjct: 161 LTPDALSDAKTVVIRPEVTAPGPVRARLLDGDREIAATEGEGELTLAGLTGLSLWSTDNP 220 Query: 248 YLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHEDADLRGKGFD 307 LY + +T D+ R G R+ + FL+N +P G RH+ +G Sbjct: 221 QLYTVELTLPDSG--DVTTHRFGFRTAEWTPQGFLLNGQPMKLRGLNRHQSWAHQGYAAG 278 Query: 308 NVLMVHDHALM-DWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFE 366 D ++ + N RTSHYP + LD DE G++V +E Sbjct: 279 RHAQERDAEIVRHDLCCNMVRTSHYPQSTWFLDRCDEIGLLVFEEIPGW----------- 327 Query: 367 AGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSI-ANEPDTRPQGAREYF 425 + + Q + ++ +I RD NHPS+V+W + NE +++ Sbjct: 328 ----------QHIGDQAWQDRSVDNVRAMITRDWNHPSIVIWGVRINE----SPDNHDFY 373 Query: 426 APLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVL 485 R+LDPTR I V + + DV +N + + + L Sbjct: 374 VRTNALARELDPTRAIGGVRCITDSEMLE------DVYTMNDFILDESELPLINRPRTAL 427 Query: 486 EKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFD---RVSA 542 K P ++TEY G E Q + + V + A Sbjct: 428 RPTEEVTGIKKPVPYLVTEY-----NGHMFPTKAQDPELRQMEHVIRHLEVLNAAHGDPA 482 Query: 543 VVGEQVWNFADFATSQGILRVGG-NKKGIFTRDRKPKSAAFLL 584 + G W D+ T + G+ R+PK AA Sbjct: 483 ISGCIGWCMFDYNTHKDFGAGDRICHHGVMDIWREPKFAAHAY 525 >5DMY-A nrPDB Length = 904 Score = 371 bits (952), Expect = e-103, Method: Composition-based stats. Identities = 136/657 (20%), Positives = 221/657 (33%), Gaps = 108/657 (16%) Query: 5 VETPTREIKKLDGLWAFSL-----DRENCGIDQRWWESALQESRAIAVPGSFNDQFADAD 59 V++ D W F L ++ D W + L +I S +++ A Sbjct: 31 VDSKQNRTSDFDANWKFMLSDSVQAQDPAFDDSAWQQVDLPHDYSITQKYSQSNEAESAY 90 Query: 60 IRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVT 119 + G WY++ I + AG+RI + FD V VW N ++ H GY+PF D+T Sbjct: 91 LP--GGTGWYRKSFTIDRDLAGKRIAINFDGVYMNATVWFNGVKLGTHPYGYSPFSFDLT 148 Query: 120 PYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTT 179 G I V V N L +++ +GI+R V L T Sbjct: 149 GNAKFGGENTIVVKVENRL---------------------PSSRWYSGSGIYRDVTLTVT 187 Query: 180 PNTWVDD-------------------ITVVTHVAQDCNHA---SVDWQVVANG---DVSV 214 V + + + T VA D A ++ V G D ++ Sbjct: 188 DGVHVGNNGVAIKTPSLATQNGGNVTMNLTTKVANDTEAAANITLKQTVFPKGGKTDAAI 247 Query: 215 ELRDADQQVVATGQG--TSGTLQVVNPHLWQPGEGYLYELCVT-AKSQTECDIYPLRVGI 271 + +A G + T+ +P LW LY + T D Y G Sbjct: 248 GTVTTASKSIAAGASADVTSTITAASPKLWSIKNPNLYTVRTEVLNGDTVLDTYDTEYGF 307 Query: 272 RSVAVKGE-QFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSH 330 R F +N + G H D G + + ++ +G NS RT+H Sbjct: 308 RWTGFDATSGFSLNGEKVKLKGVSMHHDQGSLGAVANRRAIERQVEILQKMGVNSIRTTH 367 Query: 331 YPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNK-PKELYSEEAVNGETQQAHL 389 P A+ ++D +E G++V++E + G + G + + + AV G + Sbjct: 368 NPAAKALIDVCNEKGVLVVEEVFDMWNRSKNGNTEDYGKWFGQTIAGDNAVLGGDKDETW 427 Query: 390 Q--AIKELIARDKNHPSVVMWSIANEPDTRPQGAREYF----APLAEATRKLDPTRPITC 443 + I RD+N PSV+MWS+ NE G+ F A L T+ D TRP+T Sbjct: 428 AKFDLTSTINRDRNAPSVIMWSLGNEMMEGISGSVSDFPATSAKLVAWTKAADSTRPMTY 487 Query: 444 VNVMF------CDAHTDTISDLFDVLCLNRYYG------------WYVQSGDLETAEKVL 485 + + D ++ V+ N G W + + +A Sbjct: 488 GDNKIKANWNESNTMGDNLTANGGVVGTNYSDGANYDKIRTTHPSWAIYGSETASAINSR 547 Query: 486 EKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVG 545 +T Y + G ++ + W + Q V G Sbjct: 548 GIYNRTTGGAQSSDKQLTSYDNSAV-GWGAVASSAWYDVVQ-------------RDFVAG 593 Query: 546 EQVWNFADF-----------ATSQGILRVGGNKK-GIFTRDRKPKSAAFLLQKRWTG 590 VW D+ + + G N GI PK + Q +W Sbjct: 594 TYVWTGFDYLGEPTPWNGTGSGAVGSWPSPKNSYFGIVDTAGFPKDTYYFYQSQWND 650 >3DEC-A nrPDB Length = 1000 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 129/585 (22%), Positives = 211/585 (36%), Gaps = 116/585 (19%) Query: 14 KLDGLWAFSLDRENCGIDQRWWESALQESRA--IAVPGSFN------------------- 52 L+G W F + + +++ + I VPG++ Sbjct: 46 SLNGQWKFHWVKNPDTRPKDFYKPSYYTGGWADIKVPGNWERQGYGTAIYVNETYEFDDK 105 Query: 53 --DQFADADIRNYAGN--VWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQ 108 + + + Y N Y+R +P GW G+R+VL + V + VWVN + + +Q Sbjct: 106 MFNFKKNPPLVPYKENEVGSYRRTFKVPAGWEGRRVVLCCEGVISFYYVWVNGEFLGYNQ 165 Query: 109 GGYTPFEADVTPYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYA 168 G T E D+T + G+ I + V G + D + + Sbjct: 166 GSKTAAEWDITDKLTDGE-NTIALEV------YRWSSGAYLE----------CQDMWRLS 208 Query: 169 GIHRSVMLYTTPNTWVDDITVVT-----HVAQDCNHASVDWQVVANGDVSV--ELRDADQ 221 GI R V LY+TP ++ D V + H + V A+G S+ L+DA Sbjct: 209 GIERDVYLYSTPEQYIADYKVTSLLEKEHYKEGIFELEVAVGGTASGTSSIAYTLKDASD 268 Query: 222 QVVATGQGTSGT-----------LQVVNPHLWQPGEGYLYELCVTAKS--QTECDIYPLR 268 + V G + ++ + W LY L + K +I + Sbjct: 269 KTVLEGSRKLESHGSGNLIVFDEQRLPDVRRWNAEHPELYTLLLELKDAGGKVTEITGTK 328 Query: 269 VGIRSVAVKGEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRT 328 VG R+ +K +F IN P G RHE + G+ LM D LM N+ R Sbjct: 329 VGFRTSEIKNGRFCINGVPVLVKGVNRHEHS-QLGRTVSKELMEQDIRLMKQHNINTVRN 387 Query: 329 SHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAH 388 SHYP D +G+ VIDE + G A + AH Sbjct: 388 SHYPAHPYWYQLCDRYGLYVIDEANIESHGMGYGPASL------------AKDSTWLPAH 435 Query: 389 LQAIKELIARDKNHPSVVMWSIANEPDTRPQGAREYFAPLAEATRKLDPTRPITCVNVMF 448 + + + R KNHPSVV+WS+ NE R Y + + ++ RP+ Sbjct: 436 IDRTRRMYERSKNHPSVVIWSLGNEAGNGINFERTY-----DWLKSVEKNRPVQYERAE- 489 Query: 449 CDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVD 508 + +TD ++ + + R Y ++ +++P I+ EY Sbjct: 490 ENYNTDIYCRMYRSVDVIRNY---------------------VVRKDIYRPFILCEY--- 525 Query: 509 TLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFAD 553 LH+M C + Y VF+ G +W++ D Sbjct: 526 ----LHAMGN-------SCGGMKEYWEVFENEPMAQGGCIWDWVD 559 >6ETZ-A nrPDB Length = 989 Score = 358 bits (919), Expect = 3e-99, Method: Composition-based stats. Identities = 129/606 (21%), Positives = 214/606 (35%), Gaps = 95/606 (15%) Query: 14 KLDGLWAFSLDRENCGIDQRWWE--SALQESRAIAVPGSFNDQFAD-ADIRNYAGNVWYQ 70 L+G W F L + W+ AL ++ VP S+ N + Sbjct: 38 SLNGEWQFRLSPGSRVAPDDGWQLGEALNGFESLPVPSSWPMHGHGAPAYTNVQFPFAVE 97 Query: 71 REVFIPKGWAGQRIV-------------LRFDAVTHYGKVWVNNQEVMEHQGGYTPFEAD 117 G +V LRFD + G VW+N E+ +G E D Sbjct: 98 PPHVPEANPIGDHLVVFEAGPEFFPHALLRFDGIESAGTVWLNGVELGTTRGSRLAHEFD 157 Query: 118 VTPYVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLY 177 V+ + G+ + V V + D + GI R V L Sbjct: 158 VSGILEQGE-NTLAVRV----------------AQFSAASYVEDQDMWWLPGIFRDVTLQ 200 Query: 178 TTPNTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVV 237 P +DD+ V + + G + + + GT + V Sbjct: 201 ARPAAGIDDVFVHAGYDHITGEGILKVEASRGGQAIDAVVRVPELALELAAGTEVRVPAV 260 Query: 238 NPHLWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHE 297 P W LYE V+A ++ L++G RS+A++ QF +N + G RHE Sbjct: 261 EP--WSAEVPKLYEAAVSAAGESVA----LQIGFRSIAIEDAQFKVNGRRILLRGVNRHE 314 Query: 298 DADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGF 357 G+ ++ + LM N+ RTSHYP + L AD+ G V+ E Sbjct: 315 HHPRLGRVVPRDVVEAELRLMKQHNINAIRTSHYPPHPQFLALADQLGFYVVLECDLETH 374 Query: 358 NLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTR 417 GFE+ + + + + A + ++ + RDKNH SVVMWS+ NE Sbjct: 375 ------GFESAGWAQNPSDD----PQWEDALVDRMRRTVERDKNHASVVMWSLGNE---- 420 Query: 418 PQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGD 477 G A ++ T+ DP+RPI + H D S ++ G ++ Sbjct: 421 -AGTGRNLAAMSRWTKDRDPSRPIHYEG-DWSSEHVDVYSRMYASQAETALIGQGIEPAL 478 Query: 478 LETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVF 537 + A + + P ++ EY +H+M + Y +F Sbjct: 479 NDAALDARRRAM---------PFVLCEY-------VHAMGNGP-------GGMSEYQALF 515 Query: 538 DRVSAVVGEQVWNFAD----FATSQGILRVG-----------GN--KKGIFTRDRKPKSA 580 ++ ++G VW + + +T+ G+ G GN G+ DR+P+ Sbjct: 516 EKYPRLMGGFVWEWLEHGITVSTADGVDHYGYGGDFGEEVHDGNFVTDGLVDADRRPRPG 575 Query: 581 AFLLQK 586 +K Sbjct: 576 LLDFKK 581 >5T9G-A nrPDB Length = 846 Score = 352 bits (903), Expect = 3e-97, Method: Composition-based stats. Identities = 115/653 (17%), Positives = 207/653 (31%), Gaps = 135/653 (20%) Query: 14 KLDGLWAFSLD-----RENCGIDQRWWESALQESRAIAVPGSFNDQFADADIRNYAGNVW 68 + W F+L W L ++ +P F G W Sbjct: 31 DFNNGWKFTLSDSVCYSFVNYNPSSWKTVNLPHDWSVDLP--FESTAEGCTGFLKGGIGW 88 Query: 69 YQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIA-GKS 127 Y + P + ++ + FD V + + W+N +++ H GY+PF D++ Y+ G+ Sbjct: 89 YSKTFDTPDNFVDKKCYIVFDGVYNNSEYWINGRKLGFHPYGYSPFFYDISDYLNPKGQE 148 Query: 128 VRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNTWVDDI 187 RI+V +++ + ++ +GI+R L T + Sbjct: 149 NRISVRIDHSRYADSR--------------------WYTGSGIYRETQLIFTDKLHIPVW 188 Query: 188 -TVVTHVAQDCNHASVDWQVVAN--------GDVSVELRDADQQVVATGQGT-------- 230 T VT A+V+ +V G+V D+ + V + Sbjct: 189 GTFVTTPVVSSERATVNIEVRVKNDYSGPRAGEVRTSYFDSKNKKVGEKLTSFLIEAGKE 248 Query: 231 ---SGTLQVVNPHLWQPGEGYLYELCVT-AKSQTECDIYPLRVGIRSVAVK-GEQFLINH 285 + ++++ NP LW +Y D GIRS+ + F +N Sbjct: 249 MKINQSVEISNPSLWDVDSPSMYLAKSEILVDGNVVDTKETPFGIRSIKFDAKKGFFLNG 308 Query: 286 KPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHG 345 K G H DA + G + + G N+ R SH P A+ L+ DE G Sbjct: 309 KNMKIKGVCLHHDASMIGAALVEDVWRRRLQTLKDGGCNAIRLSHNPGADAFLELCDEMG 368 Query: 346 IVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSV 405 +V +E + + + + Q+ + +K ++ R +NHP + Sbjct: 369 FLVQEEFFDEW-DYPKDKRLNMDEQSIDYITRGYCEY-FQEWAERDLKNVMLRSRNHPCI 426 Query: 406 VMWSIANEPDTRPQGARE------------YF---------------------------- 425 WSI NE + +G +E YF Sbjct: 427 FQWSIGNEIEWTYKGCKESTGFFSADAGGGYFWNQPPYSTQRIREEWAKQPKQTYDIGRT 486 Query: 426 -APLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKV 484 LA TR++D TRP+T ++ ++ D DV + Y Sbjct: 487 AKKLAAWTREMDTTRPVTANCILPSISYETGYIDALDVAGFSYRRVMYD----------- 535 Query: 485 LEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVV 544 A + +P + G + L H + + Sbjct: 536 -----YAHKNYPDKPAM----GTENLGQWHE------------------WKAVIERDYIP 568 Query: 545 GEQVWNFADFATSQGILRVGGNKK----GIFTRDRKPKSAAFLLQKRWTGMNF 593 G +W D+ G ++ G+ K + +++ WT F Sbjct: 569 GMFIWTGVDYLGEVGTKGREWPQRAIGCGLLDLAGFEKPSFHMMKSLWTDAPF 621 >4CUC-A nrPDB Length = 849 Score = 340 bits (871), Expect = 1e-93, Method: Composition-based stats. Identities = 130/656 (19%), Positives = 218/656 (33%), Gaps = 128/656 (19%) Query: 14 KLDGLWAFSLDRENC------GIDQRWWESALQESRAIAVPGSFNDQF-----ADADIRN 62 + W F L+ + W + L +I FND + + Sbjct: 17 DFNQNWYFKLNANSKEAIKPDADVSTWKKLDLPYDWSI-----FNDFDHESPAQNEGGQL 71 Query: 63 YAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYV 122 G WY++ + + + + L FD V +V+VN Q V + GY F D+T Y+ Sbjct: 72 NGGEAWYRKTFKLDEKDLKKNVRLTFDGVYMDSQVYVNGQLVGHYPNGYNQFSYDITKYL 131 Query: 123 -IAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPN 181 G+ I V N+ +++ +GI+R V L T Sbjct: 132 QKDGRENVIAVHAVNK---------------------QPSSRWYSGSGIYRDVTLQVTDK 170 Query: 182 TWVD--DITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTS-------- 231 V+ T++T ++ H V+ V + V D D ++VA Q Sbjct: 171 VHVEKNGTTILTPKLEEQQHGKVETHVTSK---IVNTDDKDHELVAEYQIVERGGHAVTG 227 Query: 232 ------------------GTLQVVNPHLWQP--GEGYLYELCVTAKSQTE-CDIYPLRVG 270 L+V P LW + LYEL + D G Sbjct: 228 LVRTASRTLKAHESTSLDAILEVERPKLWTVLNDKPALYELITRVYRDGQLVDAKKDLFG 287 Query: 271 IRSVAVKG-EQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTS 329 R E F +N + F G H D G + M +G NS RT+ Sbjct: 288 YRYYHWTPNEGFSLNGERIKFHGVSLHHDHGALGAEENYKAEYRRLKQMKEMGVNSIRTT 347 Query: 330 HYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHL 389 H P +E+ L A E G++V +E + + + ++A + E ++ Sbjct: 348 HNPASEQTLQIAAELGLLVQEEAFDTWYGGKKPYDY------GRFFEKDATHPEARKGEK 401 Query: 390 Q---AIKELIARDKNHPSVVMWSIANEPDTRPQGAREY--FAPLAEATRKLDPTRPITCV 444 ++ ++ R KN+P++ MWSI NE A L + + +D TR +T Sbjct: 402 WSDFDLRTMVERGKNNPAIFMWSIGNEIGEANGDAHSLATVKRLVKVIKDVDKTRYVTMG 461 Query: 445 NVMF----CDAHTDTISDLFDVLCLN-----------RYYGWYVQSGDLETA-----EKV 484 F + I+D D + N ++ W + +A Sbjct: 462 ADKFRFGNGSGGHEKIADELDAVGFNYSEDNYKALRAKHPKWLIYGSQTSSATRTRGSYY 521 Query: 485 LEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDR-VSAV 543 + L + ++YG D + G T W+ FDR + Sbjct: 522 RPERELKHSNGPERNYEQSDYGNDRV-GWGKTATASWT--------------FDRDNAGY 566 Query: 544 VGEQVWNFADFATSQGILRVGGNKK-------GIFTRDRKPKSAAFLLQKRWTGMN 592 G+ +W D+ + N+ GI PK +L Q +W + Sbjct: 567 AGQFIWTGTDY-IGEPTPWHNQNQTPVKSSYFGIVDTAGIPKHDFYLYQSQWVSVK 621 >5N6U-A nrPDB Length = 836 Score = 158 bits (400), Expect = 5e-39, Method: Composition-based stats. Identities = 112/682 (16%), Positives = 220/682 (32%), Gaps = 123/682 (18%) Query: 6 ETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIA------VPGSFNDQFADAD 59 + EI KLDG W F D++W ++ + + +P F + + + Sbjct: 20 HMASMEILKLDGEWEFK-----AVKDKKWRKAKVPGCVHLDLMENGLIPDPFVGEN-ELE 73 Query: 60 IRNYAGNVW-YQREVFIPKG-WAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEAD 117 ++ W Y+++ + K I L F+ + + ++++N +++ E + +E + Sbjct: 74 VQWVEKEDWIYRKKFQVGKEFLKYSSIYLEFEGIDTFSEIYLNGKKIGETDNMFIAWEFN 133 Query: 118 VTPYVIAGKSVRIT-------VCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNY--- 167 V ++ G++ V N+ G + +K Y + Sbjct: 134 VKDLLVEGENELEVRLFSPSKVLEERAKNYPYKLHGGDYSPRVFGRKAQYSFGWDWGPRL 193 Query: 168 --AGIHRSVMLYTTPNTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVA 225 +GI +SV L + D+ V + +++ + + V++ Sbjct: 194 ATSGIWKSVKLKGWNKARLLDVWVPVRSLGENAQINIELDIELQESIPVDVAFRISHKKP 253 Query: 226 TGQGTSGT------------LQVVNPHLWQPG---EGYLYELCVTAKSQT--ECDIYPLR 268 + L + NP LW P E LY L + + D R Sbjct: 254 VLEQRLRFTLPEGRVFLKIPLTIKNPKLWFPRGYGEQNLYTLQLVLLDEKGEVLDKVEER 313 Query: 269 VGIRSVAV----KGEQ----FLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALM-- 318 GIR V + + F IN+ P + G + F + D+ L+ Sbjct: 314 FGIRKVELFTQEDNKGESFVFKINNIPVFAKGAN-----WIPADSFLPRIKEEDYRLLLI 368 Query: 319 --DWIGANSYRT---SHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKE 373 G N R Y + + DE GI+V + + Sbjct: 369 RAKEAGVNMLRVWGGGIY-ENDIFYELCDELGIMVWQDFMF--------------ACAEY 413 Query: 374 LYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQ-----------GAR 422 E +N ++A +I R +NHPS+V+W N G Sbjct: 414 PDDENFLNDVQKEAEF-----VIKRLRNHPSIVLWCGNNCNHWGYYAKWWGEREKFWGEE 468 Query: 423 EYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAE 482 Y L + +LD TRP ++ D ++GW +G L+ Sbjct: 469 IYSRVLPDVCARLDLTRP--YWPSSPYGGKDPNSQEVGDRHNWEVWHGWIDFNGYLKDNG 526 Query: 483 KVLEK--ELLAWQEKLHQPIIITE---YGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVF 537 + + + + + I +E Y H+ E ++ + ++ Sbjct: 527 RFISEFGMQAPPVAETIRKFITSEKEYYPQSREMEFHN--KAREGTERIIRYIAGHFKIT 584 Query: 538 DRV-SAV------------VGEQVWNFADFATSQGILRVGGNK------KGIFTRDRKPK 578 + + + G + W F TS G L N I +K K Sbjct: 585 EDMNEYIYLSQIIQGLALKTGIEHWRNNKFHTS-GSLIWQWNDCWPVVSWSIIDYYKKLK 643 Query: 579 SAAFLLQKRWTGMNFGEKPQQG 600 + + +++ + + +P+ G Sbjct: 644 PSYYFVKRAFRDIKVNIEPRNG 665 >2WBK-A nrPDB Length = 847 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 106/666 (15%), Positives = 199/666 (29%), Gaps = 110/666 (16%) Query: 5 VETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAV-PGSFNDQFADADIRNY 63 T E+ LD W FS + + Q+ + + P F + I+ Sbjct: 1 QGNDTSEVMLLDTGWEFSQSGTEKWMPATVPGTVHQDLISHELLPNPFYGMN-EKKIQWV 59 Query: 64 AGNVW-YQREVFIPKGWAGQR-IVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPY 121 W Y+ + + + I L F+ + Y V++N +++ + + V Sbjct: 60 ENEDWEYRTSFIVSEEQLNRDGIQLIFEGLDTYADVYLNGSLLLKADNMFVGYTLPVKSV 119 Query: 122 VIAGKSVRITVCVNNELNWQTIPPGMV---------------ITDENGKKKQSYFHDFFN 166 + G++ + QT+P ++ + K SY D+ Sbjct: 120 LRKGENHLYI--YFHSPIRQTLPQYASNGFNYPADNDHHEKHLSVFSRKAPYSYGWDWGI 177 Query: 167 ---YAGIHRSVMLYTTPNTWVDDIT-----------------VVTHVAQDCNHASVDWQV 206 +G+ R V L + D +V + A V V Sbjct: 178 RMVTSGVWRPVTLRFYDIATISDYYVRQLSLTDENARLSNELIVNQIVPQKIPAEVRVNV 237 Query: 207 VANGDVSVELRDADQQVVATGQGTSGTLQVVNPHLWQP---GEGYLYELCVTA-KSQTEC 262 NG +V + + +V NP W P G LY+ Sbjct: 238 SLNGT-TVTEVKQQVTLQPGINHITLPAEVTNPVRWMPNGWGTPTLYDFSAQIACGDRIV 296 Query: 263 DIYPLRVGIRSVAVKGEQ--------FLINHKPFYFTGFG-RHEDADLRGKGFDNVLMVH 313 R+G+R++ V E+ F +N P + G +DA L Sbjct: 297 AEQSHRIGLRTIRVVNEKDKDGESFYFEVNGIPMFAKGANYIPQDALL--PNVTTERYQT 354 Query: 314 DHALMDWIGANSYRT---SHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNK 370 M N R Y D ADE+GI+V + F + Sbjct: 355 LFRDMKEANMNMVRIWGGGTYENN-LFYDLADENGILVWQDFMFACTPYPSDPTFLKRVE 413 Query: 371 PKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQG---AREYFAP 427 + +Y+ I R +NH S+ MW NE + +++ Sbjct: 414 AEAVYN-------------------IRRLRNHASLAMWCGNNEILEALKYWGFEKKFTPE 454 Query: 428 LA-EATRKLDP-TRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVL 485 + D R + V D+ + + R W G ++ + Sbjct: 455 VYQGLMHGYDKLFRELLPSTVKEFDSDRFYVHSSPYLANWGRPESW----GTGDSHNWGV 510 Query: 486 EKELLAWQE-KLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMY----------- 533 ++ P ++++G + + ++ E+YQ M Sbjct: 511 WYGKKPFESLDTDLPRFMSQFGFQSFPEMKTIAAFAAPEDYQIESEVMNAHQKSSIGNSL 570 Query: 534 HRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKS-----AAFLLQKRW 588 R + ++ E F DF +L+ G + G+ R+ + + L W Sbjct: 571 IRTYMERDYIIPES---FEDFVYVGLVLQGQGMRHGL-EAHRRNRPYCMGTLYWQLNDSW 626 Query: 589 TGMNFG 594 +++ Sbjct: 627 PVVSWS 632 >6DDT-A nrPDB Length = 868 Score = 117 bits (292), Expect = 2e-26, Method: Composition-based stats. Identities = 98/592 (16%), Positives = 179/592 (30%), Gaps = 118/592 (19%) Query: 13 KKLDGLWAFSLDRENCGIDQ---RWWESALQESRAIAVPG-SFNDQFADADIRNYAGNVW 68 L G W S + + + SAL + I P FND + N Sbjct: 12 YSLSGSWRVSNGNGSLELPATVPGYVHSALHQHGLIQDPYYRFNDLNYRWISLD---NWT 68 Query: 69 YQREVFIPKGWAG-QRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIAGKS 127 Y E IP + Q++ L FD V ++ NN + + +T + D+T V S Sbjct: 69 YSTEFKIPFNLSEWQKVKLIFDGVDTVAEILFNNVTIGKTDNMFTGYSFDITNVVKDVNS 128 Query: 128 VRI--------TVCVNNELNWQTIPP--------GMVITDENGKKKQSYFHDF---FNYA 168 +++ C + +PP G + K + S+ D+ F Sbjct: 129 LKLQFRSAVQYAECQSKAHTSYRVPPECPPVEQKGECHVNFIRKAQCSFSWDWGPSFPSQ 188 Query: 169 GIHRSVMLYTTPNTWVDDITVVTHVAQDCNHASVDWQVVAN--------GDVSVEL--RD 218 GI + V + +D +T + +++ + + G V+V + Sbjct: 189 GIWKDVRIEAYNIAHLDYLTFLPVYDNASQAWNIEIKASFDVASSKSVGGQVTVAIPQLK 248 Query: 219 ADQQVVATGQGTSGTLQV-------VNPHLWQPG---EGYLYELCVTAK-SQTECDIYPL 267 Q Q +++ V W P Y + + Sbjct: 249 TQQTNDIELQQEQRIVKLLVKIRKDVAVETWWPRGHGNQTGYNMTILFALDGGLKIEKAA 308 Query: 268 RVGIRSVAVKGEQ----------FLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHAL 317 +V R+V + E F IN P + G + F + + L Sbjct: 309 KVYFRTVQLIEEGIKGSPGLSFYFKINGLPIFLKG-----SNWIPADSFQDKVTSDRLQL 363 Query: 318 M----DWIGANSYRT---SHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNK 370 + N+ R Y E DE GI+V + GF A + Sbjct: 364 LFQSVVDANMNTLRVWGGGIYEQDE-FYALCDELGIMVWQDFMFASALYPTEPGFLASVR 422 Query: 371 PKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEP---------------- 414 + Y + R K+HPS+++WS NE Sbjct: 423 KEVTYQ-------------------VRRLKSHPSIIIWSGNNENEVALSVNWFHVNPRDM 463 Query: 415 -DTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYV 473 Y + + D +RP + T+ + + + Y + + Sbjct: 464 KTYIDDYVTLYVKNIRKIVLSEDKSRP------FIASSPTNGMKTMEE--GWISYDPYSI 515 Query: 474 QSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEY 525 Q GD+ + W + + +++EYG + ++ E++ Sbjct: 516 QYGDIHFYNYA--DDCWNW-KIFPKARLVSEYGYQSWPSFSTLEKVSSQEDW 564 >6BYC-A nrPDB Length = 862 Score = 112 bits (279), Expect = 6e-25, Method: Composition-based stats. Identities = 95/563 (16%), Positives = 166/563 (29%), Gaps = 103/563 (18%) Query: 14 KLDGLWAFSLDRE-NCGIDQRWWESALQESRAIAVPGSF--NDQFADADIRNYAGNV--- 67 LDG W L G + L AV D R+ G + Sbjct: 7 TLDGGWRVRLVPGQEQGKTYPKAAAWLPAQVPGAVQTDLIAAKIVPDPFYRDNEGKIQWA 66 Query: 68 ----W-YQREVFIPKG-WAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPY 121 W YQ + + + L FD + + +V +N ++++ + + D Sbjct: 67 GLSDWQYQTRFTVDAATLKREHVELVFDGLDTFAEVTLNGKQLLSADNMFRQWRVDAKSL 126 Query: 122 VIAGKSVRITVCVNN---------ELNWQTIP---------PGMVITDENGKKKQSYFHD 163 + G ++ + V + + +P +K Y Sbjct: 127 LKRGDNL-LEVKLYSPIKKIQPWLAKQPYALPGAYDSAFGDEPEARHSSTYVRKAPYNFG 185 Query: 164 FFNY-----AGIHRSVMLYTTPNTWVDDITVVTHVAQ---DCNHASVDWQVVANGDVSVE 215 + AGI + V + VD + + A +D Q +G V V Sbjct: 186 WDWGPRMVNAGIWKDVRVEAWDAVRVDGLHIAQQRVDAHSAQVQAQLDLQAGRSGPVQVT 245 Query: 216 L------------RDADQQVVATGQGTSGTLQVVNPHLWQP---GEGYLYELCVTAKS-Q 259 L D V +++ NP W P G Y + + Sbjct: 246 LDVLGPDGQKVGQFTQDAVVDPGQNRVDLAVRIANPKRWFPAGYGAQDRYTFVASVRDAD 305 Query: 260 TECDIYPLRVGIRSVAVKGEQ--------FLINHKPFYFTGFGRHEDADLRGKGFDNVLM 311 + G+RSV ++ E+ +IN P + G + M Sbjct: 306 GDSQQIKRVTGLRSVELRREKDRFGKSMEIVINGIPIFAKGANLIPLDAFPARVTHER-M 364 Query: 312 VHDHALMDWIGANSYRT---SHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAG 368 N R HY + D ADE GI++ + G + F Sbjct: 365 RSTLQDARDANMNMLRMWGGGHY-QDDYFYDVADELGIMIWQDFMFGGAVPPYDVEF--- 420 Query: 369 NKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQGAREYFAPL 428 ++ Q E + R ++HPS+V+W NE T + + Sbjct: 421 ----------------RENTRQEAIEQVKRLRDHPSLVLWCGNNEVQTGWENWGDRVK-- 462 Query: 429 AEATRKLDP---TRPITCVNVMFCDAHTDTISDL-FDVLCLNRYYGWYVQSG-DLETAEK 483 + +DP TR + +F + ++ DV W G D + A Sbjct: 463 --FKQSVDPEERTRIERGMTTLFGTVFREVVATYDSDV------PYWATSPGTDFDGAAD 514 Query: 484 VLEK-ELLAWQEKLHQPIIITEY 505 ++ W+ + +TEY Sbjct: 515 QTNDGDMHYWKVWGGPALPVTEY 537 >4CVU-A nrPDB Length = 942 Score = 69.7 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 83/478 (17%), Positives = 134/478 (28%), Gaps = 101/478 (21%) Query: 18 LWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADIRNYAGNVWYQREVFIPK 77 W + + N + ++ A + A V G N+ D D+R A W I Sbjct: 37 KWTVTNEYGNITVPGKFPSQAHLDLHAAGVIGESNNGLNDFDLRWIAAQNWTYTSKPISG 96 Query: 78 GWAGQRI--VLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYV-----------IA 124 I L FD + Y V + V + + DV+ + Sbjct: 97 LSKHSDIATWLVFDGLDTYATVKFCDHIVGTPDNQFRQWFYDVSSALASCKSDPVLSINF 156 Query: 125 GKSVRITVCVNNELNWQTIPPGMVIT----DENGKKKQSYFHDFFNYAGIH--------R 172 G RI +N Q P +V + +K+ + R Sbjct: 157 GSVPRIINAINASDEVQHWPASVVYPFEYPNRQWVRKEQNDFGWDWGPAFSPVGPWQPGR 216 Query: 173 SVMLYTTPNTWVDDITVV-------THVAQDC-----------------NHASVDWQVVA 208 V L + + + + A D HAS+ + Sbjct: 217 IVQLSKGGELYSLNTDIDIFRKGQFNNFAPDQTAPWVVNASLDFLGTLPKHASMSVIITD 276 Query: 209 NGDVSVELRDADQQVVATGQGT---SGTLQVVNPHLWQPG---EGYLYELCVTA---KSQ 259 D L + V T S T+ P LW P LY + V+ S+ Sbjct: 277 ASDSRSVLYSGKLEGVTQSDMTVTGSVTIDAHKPKLWWPRDMGNQQLYNITVSVSSAGSK 336 Query: 260 TECDIYPLRVGIRSVAVKGEQ-----------------FLINHKPFYFTGFGRHEDADLR 302 T + RVG R++ F IN FY G Sbjct: 337 TPILVSQRRVGFRTILFSSGNITDAQIASGITPGNNWHFEINGHEFYAKGANLIPPDAFW 396 Query: 303 GKGFDNVLMVHDHALMDWIGANSYRT----SHYPYAEEMLDWADEHGIVVIDETAAVGFN 358 + + + ++ N R ++ P + + D ADE G+++ E Sbjct: 397 PRVTSDRMN-RLFDSVESQNFNMLRVWSSGTYLP--DWIYDIADERGVLLWSEF------ 447 Query: 359 LSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDT 416 F P + V GE + R +H S+ W NE + Sbjct: 448 -----QFSDTLYPDSDDFKANVVGEITYN--------VRRLNHHASLACWMGGNEFEN 492 >3ZIZ-A nrPDB Length = 382 Score = 57.4 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 41/248 (16%), Positives = 77/248 (31%), Gaps = 35/248 (14%) Query: 335 EEMLDWADEHGI-VVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIK 393 + ++ A+ GI ++I + A KE + N Q+ + + I+ Sbjct: 104 DYLVRSAETRGIKLIIALVNYWDDFGGMKAYVNAFGGTKESWY---TNARAQEQYKRYIQ 160 Query: 394 ELIARDKNHPSVVMWSIANEPDTRPQGAREYF---APLAEATRKLDPTRPITCVNVMFCD 450 +++R N P++ W +ANEP + F +++ R LD IT + F Sbjct: 161 AVVSRYVNSPAIFAWELANEPRCKGCNTNVIFNWATQISDYIRSLDKDHLITLGDEGFGL 220 Query: 451 AHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTL 510 Y Y + D ++ + + + T +G + Sbjct: 221 P------------GQTTYPYQYGEGTDFVKNLQIKNLDFGTFHMYPGHWGVPTSFGPGWI 268 Query: 511 AGL----HSMYTDMWSEEY---------QCAWLDMYHRVFDRVSAVVGEQVWNFADFATS 557 + EEY Q W + + G+ W + D S Sbjct: 269 KDHAAACRAAGKPCLLEEYGYESDRCNVQKGWQQASREL--SRDGMSGDLFWQWGD-QLS 325 Query: 558 QGILRVGG 565 G G Sbjct: 326 TGQTHNDG 333 >3D3A-A nrPDB Length = 612 Score = 50.1 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 47/288 (16%), Positives = 91/288 (31%), Gaps = 49/288 (17%) Query: 273 SVAVKGEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTS--- 329 + V FL+N +PF H H + +G N+ Sbjct: 7 TFEVGKNTFLLNGEPFVVKAAEIHYPR------IPKEYWEHRIKMCKALGMNTICLYVFW 60 Query: 330 --HYPYAE-----------EMLDWADEHGIVVI--------DETAAVGFNLSLGIGFEAG 368 H P A E+G+ VI E G L + Sbjct: 61 NFHEPEEGRYDFAGQKDIAAFCRLAQENGMYVIVRPGPYVCAEWEMGGLPWWLLKKKDIK 120 Query: 369 NKPKELYSEEAVNGETQQAHLQAIKEL-IARDKNHPSVVMWSIANEPDTRPQGAREYFAP 427 + ++ Y E V + + +L I++ N ++M + NE + Y + Sbjct: 121 LREQDPYYMERV-KLFLNEVGKQLADLQISKGGN---IIMVQVENEYGAFGID-KPYISE 175 Query: 428 LAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEK 487 + + ++ T V + CD +++ ++ D L +G +G + K Sbjct: 176 IRDMVKQA----GFTGVPLFQCDWNSNFENNALDDLLWTINFG----TGANIDEQFKRLK 227 Query: 488 ELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHR 535 EL + P++ +E+ + + +EE +M R Sbjct: 228 EL-----RPDTPLMCSEFWSGWFDHWGAKHETRSAEELVKGMKEMLDR 270 >6EON-A nrPDB Length = 779 Score = 47.8 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 49/288 (17%), Positives = 88/288 (30%), Gaps = 49/288 (17%) Query: 273 SVAVKGEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTS--- 329 + V FL+N +PF H H + +G N+ Sbjct: 27 TFEVGKNTFLLNGEPFVVKAAEIHYPR------IPKEYWEHRIKMCKALGMNTICLYVFW 80 Query: 330 --HYPYAE-----------EMLDWADEHGIVVI--------DETAAVGFNLSLGIGFEAG 368 H P A E+G+ VI E G L + Sbjct: 81 NFHEPEEGRYDFAGQKDIAAFCRLAQENGMYVIVRPGPYVCAEWEMGGLPWWLLKKKDIK 140 Query: 369 NKPKELYSEEAVNGETQQAHLQAIKEL-IARDKNHPSVVMWSIANEPDTRPQGAREYFAP 427 + ++ Y E V + + +L I++ N ++M + N GA P Sbjct: 141 LREQDPYYMERV-KLFLNEVGKQLADLQISKGGN---IIMVQVEN-----AYGAFGIDKP 191 Query: 428 LAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEK 487 R + T V + CD +++ ++ D L +G +G + K Sbjct: 192 YISEIRDMVKQAGFTGVPLFQCDWNSNFENNALDDLLWTINFG----TGANIDEQFKRLK 247 Query: 488 ELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHR 535 EL + P++ +E+ + + +EE +M R Sbjct: 248 EL-----RPDTPLMCSEFWSGWFDHWGAKHETRSAEELVKGMKEMLDR 290 >4AWE-A nrPDB Length = 387 Score = 44.7 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 40/266 (15%), Positives = 83/266 (31%), Gaps = 48/266 (18%) Query: 356 GFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPD 415 + G+ N + + + + ++A + +K ++ R ++ +++ W +ANE Sbjct: 124 NWADYGGMDVYTVNLGGKYHDDFYTVPKIKEAFKRYVKAMVTRYRDSEAILAWELANEAR 183 Query: 416 TRPQGAREY---------------FAPLAEATRKLDPTRPIT-----------------C 443 G R ++ + LD +T Sbjct: 184 CGADGTRNLPRSEKGCTTETVTGWIEEMSAYVKSLDGNHLVTWGGEGGFNRGEDEEDGFY 243 Query: 444 VNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIIT 503 D + D ++ Y W+ +S + + A ++P+++ Sbjct: 244 NGADGGDFDRELGLRNVDFGTMHLYPDWWSKSIEWSN---QWIHDHAASGRAANKPVVLE 300 Query: 504 EYGVDTLAGLHSMYTDMWSE---EYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATSQGI 560 EYG T G + +E E W + ++ + G+ W F G Sbjct: 301 EYGWMTDKGRLDQLGQVKNETRLEVVGGWQK--IAIQEK---LAGDMYWQF-----GYGG 350 Query: 561 LRVGGNKKGIFTRDRKPKSAAFLLQK 586 G N FT + A L+ K Sbjct: 351 YSYGRNHDDSFTIYLEDDEAKELVYK 376 >4XZW-A nrPDB Length = 313 Score = 44.3 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 50/256 (19%), Positives = 77/256 (30%), Gaps = 61/256 (23%) Query: 282 LIN--HKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHY--PYA--- 334 L+N KPF G H G+ + L D AN R + Y P A Sbjct: 19 LLNRDGKPFQLRGISTHGLQWF-GQFANKDAFQ---TLRDDWKANVVRLAMYTDPNANGY 74 Query: 335 ---EEML--------DWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGE 383 E L + A E G+ VI + Sbjct: 75 IAQPEWLKAKVKEGVEAAKELGMYVI---------------------IDWHILNDNDPNL 113 Query: 384 TQQAHLQAIKELIARDKNHPSVVMWSIANEPDTR---PQGAREYFAPLAEATRKLDPTRP 440 ++ + E+ N P+V+ IANEP+ + R Y + R +D Sbjct: 114 YKEQAKRFFAEMAREYGNTPNVIY-EIANEPNGDVTWEEKIRPYADEVIRTIRSIDRDNL 172 Query: 441 ITCVNVMFCDAHTDTISDLFD----VLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKL 496 I + D SD + L+ Y G + Q ++ + Sbjct: 173 IIVGTGTWSQDVDDVASDPLPYKNIMYALHFYAGTHGQ----------FLRDKANYALSK 222 Query: 497 HQPIIITEYGVDTLAG 512 PI +TE+G +G Sbjct: 223 GTPIFVTEWGTSDASG 238 >1UUQ-A nrPDB Length = 440 Score = 43.9 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 29/172 (16%), Positives = 63/172 (36%), Gaps = 25/172 (14%) Query: 405 VVMWSIANEPDTRPQGA--------REYFAPLAEATRKLDPTRPITCVNV---------- 446 ++ W +ANEP ++ A + LD ++ + Sbjct: 207 IMSWQLANEPRPGNSQTTAEEKQIYIDWVHAAAAYIKTLDAHHLVSSGSEGEMGSVNDMQ 266 Query: 447 MFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELL------AWQEKLHQPI 500 +F DAH D R + W+ ++ ET EK ++L++P+ Sbjct: 267 VFIDAHATPDIDYLTYHMWIRNWSWFDKTKPAETWPSAWEKAQNYMRAHIDVAKQLNKPL 326 Query: 501 IITEYGVDTLAGLHSMYT-DMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNF 551 ++ E+G+D G ++M + + + Y ++ ++ G +W + Sbjct: 327 VLEEFGLDRDMGSYAMDSTTEYRDNYFRGVFELMLASLEQGEPSAGYNIWAW 378 Score = 30.4 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 15/57 (26%), Positives = 21/57 (36%), Gaps = 4/57 (7%) Query: 274 VAVKGEQFLINHKPFYFTGFGRHEDADLRGK---GFDNVLMVHDHALMDWIGANSYR 327 V V G F + KP+ TG A G D + + + IG N+ R Sbjct: 25 VRVNGGHFELQGKPYVITGVNMWY-AAYLGAPNEVGDRDRLAKELDNLKAIGVNNLR 80 >4NRS-A nrPDB Length = 449 Score = 43.2 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 54/363 (14%), Positives = 98/363 (26%), Gaps = 88/363 (24%) Query: 268 RVGIRSVAVKGEQFLINHKPFYFTGFGRHEDADLRG---KGFDNVLMVHDHALMDWIGAN 324 +A G+ F +P+ G + +L G D M + M +G N Sbjct: 35 EFAFVKIASDGKGFTRYGEPYLIRGANYWQGMNLGADDCSGGDRKRMELEIKQMAEMGIN 94 Query: 325 SYRT----------------SHYPYA-----------EEMLDWADEH------------- 344 + R S P + +LD D + Sbjct: 95 NLRVMASSEGPDDQPYRMRPSMMPQPGKYNEGVFVGLDYLLDTMDRYNMTAVMTLGNFWQ 154 Query: 345 ---GI---VVI----DETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKE 394 G V +++ + + + + H+ ++ Sbjct: 155 WSGGFGQYVAWITGNQTIPYPVGDVTYDEFTQFAARFYNDSEIAPKANKLFKDHIYTVQN 214 Query: 395 LIARD-------KNHPSVVMWSIANEPDTRPQGAREYFAPLAEATRKLDPTRPITCVN-- 445 R+ K P ++ W IAN P P +F ++ +K P ++ Sbjct: 215 --RRNTVNGKIYKEDPVIMSWQIANAPQEAPAS---WFEEISTFIKKGAPKHLVSAGLES 269 Query: 446 ----VMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLE------KELLAWQEK 495 F AH D C +G Y D + E + W + Sbjct: 270 KLDEYDFDRAHDHKNIDYTTCHCWVENWGIY-DPADPDGLPHANEYMHDFLESRSKWAAQ 328 Query: 496 LHQPIIITEYGV---------DTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGE 546 L++PI++ E+G+ D +EY + + S G Sbjct: 329 LNKPIVMEEFGMARDAWRNPEDETYKYLPSTPTSHKDEYYQKAFNQIVSLASNRSF-SGS 387 Query: 547 QVW 549 W Sbjct: 388 NFW 390 >1VFF-A nrPDB Length = 423 Score = 42.0 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 24/97 (24%), Positives = 40/97 (41%), Gaps = 19/97 (19%) Query: 495 KLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFAD- 553 + +P+ ITE G+ TL D W E+ L H+ + V G W+F D Sbjct: 315 RYGRPLYITENGIATL-------DDEWRVEFIIQHLQYVHKAIEDGLDVRGYFYWSFMDN 367 Query: 554 ------FATSQGILRVGGNKKGIFTRDRKPKSAAFLL 584 F G++ V T +R+P+ +A++ Sbjct: 368 YEWKEGFGPRFGLVEVDYQ-----TFERRPRKSAYVY 399 >4UOQ-A nrPDB Length = 695 Score = 41.2 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 30/193 (15%), Positives = 57/193 (29%), Gaps = 35/193 (18%) Query: 307 DNVLMVHDHALMDWIGANSYRTSHYPYA-----------EEMLDWADEH---GIVV---- 348 + D LM G N + + +A + + D+ GI V Sbjct: 35 PEDVQDEDIRLMKQAGVNIVSLAIFSWANIETSDGNFEFDWLDRVIDKLYKAGIAVDLAS 94 Query: 349 -------IDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKN 401 +A G ++ + + + L+ +E+ K+ Sbjct: 95 ATASPPMWLTSAHPEVLRRDEQGHVIWPGARQHW--RPTSPTFRTYALRLCREMAEHYKD 152 Query: 402 HPSVVMWSIANEPDTRP--QGAREYFAPLAEATRKLDPTRPITC--VNVMFCDAHTDTIS 457 +P++V W + NE + + E R R T VN + Sbjct: 153 NPAIVSWHVGNEYGCHNYFDYSDDAVQAFREWCRD----RYGTIDKVNAAWGTNFWSQRL 208 Query: 458 DLFDVLCLNRYYG 470 + F+ + RY G Sbjct: 209 NSFEEILPPRYVG 221 >1QNO-A nrPDB Length = 344 Score = 40.8 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 25/200 (12%), Positives = 59/200 (29%), Gaps = 40/200 (20%) Query: 335 EEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKE 394 + ++ A++H + +I V G N + N Q + + ++ Sbjct: 93 DYVVQSAEQHNLKLI--IPFVNNWSDYGGINAYVNAFGGNATTWYTNTAAQTQYRKYVQA 150 Query: 395 LIARDKNHPSVVMWSIANEP---DTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDA 451 +++R N ++ W + NEP ++ +++ + LD +T + + Sbjct: 151 VVSRYANSTAIFAWELGNEPRCNGCSTDVIVQWATSVSQYVKSLDSNHLVTLGDEGLGLS 210 Query: 452 HTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKEL-------LAWQEKL-------- 496 D Y + D ++ + +W Sbjct: 211 TGDGAYPYT-----------YGEGTDFAKNVQIKSLDFGTFHLYPDSWGTNYTWGNGWIQ 259 Query: 497 ---------HQPIIITEYGV 507 +P + EYG Sbjct: 260 THAAACLAAGKPCVFEEYGA 279 >3UG4-A nrPDB Length = 504 Score = 39.7 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 26/145 (17%), Positives = 43/145 (29%), Gaps = 28/145 (19%) Query: 335 EEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKE 394 +E +++ E G E + N+ G EA + + + Sbjct: 127 DEFIEYCREIG----AE-PYISINMGTGTLDEALHWLEYCNGKGNTYYAQL--------- 172 Query: 395 LIARDKNHP---SVVMWSIANEP--------DTRPQGAREYFAPLAEATRKLDPTRPITC 443 R HP +V W I NE T + AR + + DPT Sbjct: 173 --RRKYGHPEPYNVKFWGIGNEMYGEWQVGHMTADEYARA-AKEYTKWMKVFDPTIKAIA 229 Query: 444 VNVMFCDAHTDTISDLFDVLCLNRY 468 V + + + DV+ Y Sbjct: 230 VGCDDPIWNLRVLQEAGDVIDFISY 254 >3WF0-A nrPDB Length = 678 Score = 38.9 bits (89), Expect = 0.007, Method: Composition-based stats. Identities = 47/287 (16%), Positives = 85/287 (29%), Gaps = 40/287 (13%) Query: 272 RSVAVK--GEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRT- 328 R + + FL + +PF + H M G N+ +T Sbjct: 31 RMFEIDYSRDSFLKDGQPFRYISGSIHYSR------VPRFYWKDRLLKMKMAGLNAIQTY 84 Query: 329 ----------SHYPYAE-----EMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKE 373 Y ++E L A E G++VI G A KE Sbjct: 85 VPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEKE 144 Query: 374 LYSEEAVNGETQQAHLQAIKELIARDK-----NHPSVVMWSIANEPDTRPQGAREYFAPL 428 + + + A + + L+ + K N V+ + NE + +Y L Sbjct: 145 SILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFL 204 Query: 429 AEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKE 488 + R + TD F G Y + D T + + Sbjct: 205 QK--------RFRHHLGDDVVLFTTDGAHKTFLKCG--ALQGLYT-TVDFGTGSNITDAF 253 Query: 489 LLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHR 535 L + + P+I +E+ L ++ + +E + D+ R Sbjct: 254 LSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILAR 300 Score = 28.9 bits (63), Expect = 6.6, Method: Composition-based stats. Identities = 14/57 (24%), Positives = 23/57 (40%), Gaps = 3/57 (5%) Query: 53 DQFADADIRNYAGNVWYQREVFIPKGWAG--QRIVLRFDAVTHYGKVWVNNQEVMEH 107 D+ + NY +Y IP G Q ++F T G+VW+N + + Sbjct: 537 DEAWAHNSSNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGWT-KGQVWINGFNLGRY 592 >2CKS-A nrPDB Length = 306 Score = 38.5 bits (88), Expect = 0.009, Method: Composition-based stats. Identities = 51/290 (17%), Positives = 86/290 (29%), Gaps = 57/290 (19%) Query: 285 HKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAE--------- 335 P G H D+ L AL A+ R S Y + Sbjct: 23 GNPVQLRGMSTHGIQWFDHCLTDSSLD----ALAYDWKADIIRLSMYIQEDGYETNPRGF 78 Query: 336 -----EMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQ 390 +++D A G+ VI L+ G ++ K ++E A ++ Sbjct: 79 TDRMHQLIDMATARGLYVI----VDWHILTPGDPHYNLDRAKTFFAEIAQRHASKTN--- 131 Query: 391 AIKELIARDKNHPSVVMWSIANEPDTRP-QGAREYFAPLAEATRKLDPTRPITCVNVMFC 449 V++ IANEP+ + Y + R+ DP I + Sbjct: 132 ---------------VLYEIANEPNGVSWASIKSYAEEVIPVIRQRDPDSVIIVGTRGWS 176 Query: 450 DAHTDTISDLFDVLC--LNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGV 507 S ++ +N Y + L E P+ +TE+G Sbjct: 177 SLGVSEGSGPAEIAANPVNASNIMYAFHFYAASHRDNYLNALREASELF--PVFVTEFGT 234 Query: 508 DTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFA-DFAT 556 +T G + M D Y + +G WN++ DF + Sbjct: 235 ETYTGDGANDFQM---------ADRYIDLMAERK--IGWTKWNYSDDFRS 273 >3PZ9-A nrPDB Length = 383 Score = 38.5 bits (88), Expect = 0.009, Method: Composition-based stats. Identities = 27/209 (12%), Positives = 62/209 (29%), Gaps = 39/209 (18%) Query: 335 EEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKE 394 + + A E GI +I V G + + ++ E + + Sbjct: 103 DYTIAKAKELGIKLI--IVLVNNWDDFGGMNQYVRWFGGTHHDDFYRDERIKEEYKKYVS 160 Query: 395 LIARDKN---------HPSVVMWSIANEPDTRPQGA----REYFAPLAEATRKLDPTRPI 441 + N P+++ W +ANE + E+ ++ + LDP + Sbjct: 161 FLINHVNVYTGVPYREEPTIMAWELANELRCETDKSGNTLVEWVKEMSSYIKSLDPNHLV 220 Query: 442 TCVNVMFCDAHTDT-----------------------ISDLFDVLCLNRYYG-WYVQSGD 477 + F + + D + Y W V + Sbjct: 221 AVGDEGFFSNYEGFKPYGGEAEWAYNGWSGVDWKKLLSIETVDFGTFHLYPSHWGVSPEN 280 Query: 478 LETAEKVLEKELLAWQEKLHQPIIITEYG 506 ++ + +++ +P+++ EYG Sbjct: 281 YAQWGAKWIEDHIKIAKEIGKPVVLEEYG 309 >2RGL-A nrPDB Length = 481 Score = 37.8 bits (86), Expect = 0.013, Method: Composition-based stats. Identities = 24/104 (23%), Positives = 44/104 (42%), Gaps = 15/104 (14%) Query: 493 QEKLHQP-IIITEYGVDTLAGLHSMYTDMWSEE--YQCAWLDMYHRVFDRVSAVVGEQVW 549 ++K P ++ITE G+D A L + + ++L + D + V G W Sbjct: 379 KQKYGNPTVVITENGMDQPANLSRDQYLRDTTRVHFYRSYLTQLKKAIDEGANVAGYFAW 438 Query: 550 NFAD-------FATSQGILRVGGNKKGIFTRDRKPKSAAFLLQK 586 + D + + GI+ V N T +R PK++A+ + Sbjct: 439 SLLDNFEWLSGYTSKFGIVYVDFN-----TLERHPKASAYWFRD 477 >2Z1S-A nrPDB Length = 454 Score = 37.8 bits (86), Expect = 0.014, Method: Composition-based stats. Identities = 31/127 (24%), Positives = 46/127 (36%), Gaps = 20/127 (15%) Query: 469 YGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGV---DTLAGLHSMYTDMWSEEY 525 GW + +EK+ PI+ITE G D L T + Y Sbjct: 332 MGWEIHPESFYKLLTRIEKDFSK-----GLPILITENGAAMRDELVNGQIEDTGR--QRY 384 Query: 526 QCAWLDMYHRVFDRVSAVVGEQVWNFAD-FATSQGILRVGGNKKGIF-----TRDRKPKS 579 L HR + + G VW+F D F + G + GI T++R PK Sbjct: 385 IEEHLKACHRFIEEGGQLKGYFVWSFLDNFEWAWGYSKRF----GIVHINYETQERTPKQ 440 Query: 580 AAFLLQK 586 +A ++ Sbjct: 441 SALWFKQ 447 Score = 29.7 bits (65), Expect = 4.0, Method: Composition-based stats. Identities = 25/115 (21%), Positives = 37/115 (32%), Gaps = 18/115 (15%) Query: 310 LMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGN 369 D LM +G HY ++ GI I+E + + L AG Sbjct: 68 HFKEDVQLMKQLG-----FLHYRFSVAWPRIMPAAGI--INEEGLLFYEHLLDEIELAGL 120 Query: 370 KPKELYSEEAVNGETQQAH-LQAIKELIARDKNHPSVVM---------WSIANEP 414 P L + + +E I K + SV+M W+ NEP Sbjct: 121 IPM-LTLYHWDLPQWIEDEGGWTQRETIQHFKTYASVIMDRFGERINWWNTINEP 174 >3WH9-A nrPDB Length = 345 Score = 37.8 bits (86), Expect = 0.014, Method: Composition-based stats. Identities = 30/186 (16%), Positives = 54/186 (29%), Gaps = 28/186 (15%) Query: 357 FNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANE--- 413 + G+ ++ + Q A+ IK ++ R N +V W +ANE Sbjct: 112 WTDYGGMSAYVSAYGGSGETDFYTSDTMQSAYQTYIKTVVERYSNSSAVFAWELANEPRC 171 Query: 414 PDTRPQGAREYFAPLAEATRKLDPTRPITCV-----------------NVMFCDAHTDTI 456 P + ++ + LD R + + + Sbjct: 172 PSCDTSVLYNWIEKTSKFIKGLDADRMVCIGDEGFGLNIDSDGSYPYQFSEGLNFTMNLD 231 Query: 457 SDLFDVLCLNRYY-GWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHS 515 D D L+ Y W G + A + +P ++ EYGV + H Sbjct: 232 IDTIDFGTLHLYPDSW----GTSDDWGNGWITAHGAACKAAGKPCLLEEYGVTSN---HC 284 Query: 516 MYTDMW 521 W Sbjct: 285 SVEGAW 290 >1HRI-3 nrPDB Length = 236 Score = 37.4 bits (85), Expect = 0.017, Method: Composition-based stats. Identities = 18/61 (29%), Positives = 28/61 (45%), Gaps = 4/61 (6%) Query: 35 WESALQESRAIAVPGSFNDQF--ADADIRNYAG--NVWYQREVFIPKGWAGQRIVLRFDA 90 W+ LQ + + +P + QF D D AG + WYQ + +P GQ +L F + Sbjct: 153 WDIGLQSTIVMTIPWTSGVQFRYTDPDTYTSAGFLSCWYQTSLILPPETTGQVYLLSFIS 212 Query: 91 V 91 Sbjct: 213 A 213 >1RH9-A nrPDB Length = 373 Score = 37.0 bits (84), Expect = 0.022, Method: Composition-based stats. Identities = 50/296 (16%), Positives = 91/296 (30%), Gaps = 69/296 (23%) Query: 276 VKGEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVH---DHALMDWIGANSYRT---S 329 G F +N K Y GF L +D + N RT S Sbjct: 9 TDGTHFALNGKSLYINGFNA---YWLMYIAYDPSTRIKVTNTFQQASKYKMNVARTWAFS 65 Query: 330 H---YP-------YAEEMLDWADEHGIVVIDETAAVGFN--LSLGIGFEAGNKPKEL--- 374 H P Y E+M D VI E G + +SL ++A K+ Sbjct: 66 HGGSRPLQSAPGVYNEQMFQGLD----FVISEAKKYGIHLIMSLVNNWDAFGGKKQYVEW 121 Query: 375 ----------YSEEAVNGETQQAHLQAIKELIAR--------DKNHPSVVMWSIANEPDT 416 + N + + +K ++ R K+ P+++ W + NEP Sbjct: 122 AVQRGQKLTSDDDFFTNPMVKGFYKNNVKVVLTRVNTITKVAYKDDPTILSWELINEPRC 181 Query: 417 RPQGAREYFA----PLAEATRKLDPTRPITCVNVMF----------------CDAHTDTI 456 + + F +A + +D + F + ++ Sbjct: 182 PSDLSGKTFQNWVLEMAGYLKSIDSNHLLEIGLEGFYGNDMRQYNPNSYIFGTNFISNNQ 241 Query: 457 SDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEK---LHQPIIITEYGVDT 509 D ++ Y ++ E +K + + + L +P++I E+G T Sbjct: 242 VQGIDFTTIHMYPNQWLPGLTQEAQDKWASQWIQVHIDDSKMLKKPLLIAEFGKST 297 >4XZB-A nrPDB Length = 314 Score = 36.2 bits (82), Expect = 0.036, Method: Composition-based stats. Identities = 55/301 (18%), Positives = 92/301 (30%), Gaps = 47/301 (15%) Query: 282 LIN--HKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHY--PYAEEM 337 L+N +KPF G H G+ + L D AN R + Y P A Sbjct: 19 LLNQHNKPFQLRGISTHGLQWF-GQFANKDAFQ---TLRDDWKANVVRLAMYTDPNAN-- 72 Query: 338 LDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYS--EEAVNGETQQAHLQAIKEL 395 G + E + + G + + ++ + E+ Sbjct: 73 -------GYIAQPEWLKAKVKEGVQAALDLGMYVIIDWHILNDNDPNLYKEQAKRFFAEM 125 Query: 396 IARDKNHPSVVMWSIANEPDTRP----QGAREYFAPLAEATRKLDPTRPITCVNVMFCDA 451 +P+V+ IANEP+ + R Y + R +D I + Sbjct: 126 AREYGKYPNVIY-EIANEPNGNDVTWEEKIRPYADEVIRTIRSIDRDNLIIVGTGTWSQD 184 Query: 452 HTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLA 511 D SD N Y + SG T + L + A + P+ ++E+G + Sbjct: 185 VDDVASDPL--PYKNIMYAVHFYSG---THTQWLRDRVDA-ALQAGTPVFVSEWGTSDAS 238 Query: 512 GLHSMY---TDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKK 568 G Y + W E + + W+ D + LR G + Sbjct: 239 GDGGPYLEEAEKWIEFLNERGISWVN--------------WSLCDKNEASAALRPGADPH 284 Query: 569 G 569 G Sbjct: 285 G 285 >3WFL-A nrPDB Length = 342 Score = 35.5 bits (80), Expect = 0.063, Method: Composition-based stats. Identities = 33/223 (14%), Positives = 59/223 (26%), Gaps = 40/223 (17%) Query: 352 TAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIA 411 V G N + + +Q A+ IK +++R + P+V W +A Sbjct: 107 INFVNNWSDYGGIPAYVNAFGGSTTSWYTDEASQAAYRNYIKTVVSRYIDSPAVFAWELA 166 Query: 412 NEP---DTRPQGAREYFAPLAEATRKLDPTRPITCVN-----------------VMFCDA 451 NEP + A + + +D + + + Sbjct: 167 NEPRCHGCDTSVIYNWVAATSSFIKSIDSQHLVCIGDEGLGLDIDSDGSYPYSYYEGTNF 226 Query: 452 HTDTISDLFDVLCLNRYY-GWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTL 510 + D D + Y W G + A +P + EYGV Sbjct: 227 TLNLGVDTIDFGTFHLYPSSW----GVSNSFGSPWVTAHGAACAAAGKPCLFEEYGVT-- 280 Query: 511 AGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFAD 553 S++ D + + W F D Sbjct: 281 -----------SDKCSVEG-GWQQTALDTR-GIGADSFWQFGD 310 >3VUP-A nrPDB Length = 351 Score = 35.5 bits (80), Expect = 0.069, Method: Composition-based stats. Identities = 25/164 (15%), Positives = 54/164 (32%), Gaps = 21/164 (12%) Query: 274 VAVKGEQFLINHKPFYFTGFGR-----HEDADLRGKGFDNVLMVHDHALMDWIGANSYRT 328 + ++ F++N + + +G D + + + + G NS R Sbjct: 2 LHIQNGHFVLNGQRVFLSGGNLPWMSYAYDFGDGQWQRNKNRIEPEFKKLHDAGGNSMRL 61 Query: 329 -SHYP-------YAEEMLDWADEHGIVVIDETAAVGFNLSLGI--GFEAGNKPKELYSEE 378 H + + D+ G ++ D + I N S Sbjct: 62 WIHIQGETTPAFNDQGFVTGPDKQGTMLDDMKDLLDTAKKYNILVFPCLWNAAVNQDSHN 121 Query: 379 AVNGETQQAHL------QAIKELIARDKNHPSVVMWSIANEPDT 416 ++G + H +A+K ++ K H ++ W + NEP+ Sbjct: 122 RLDGLIKDQHKLQSYIDKALKPIVNHVKGHVALGGWDLMNEPEG 165 >4UCF-A nrPDB Length = 689 Score = 35.5 bits (80), Expect = 0.070, Method: Composition-based stats. Identities = 35/192 (18%), Positives = 59/192 (30%), Gaps = 33/192 (17%) Query: 307 DNVLMVHDHALMDWIGANSYRTSHY----------PYAEEMLDWA-DEH---GIVV---- 348 + D LM G N + Y + LD A D+ GI V Sbjct: 32 PEEVWDDDIRLMKKAGVNLVSVGIFSWAKIEPEEGKYDFDWLDRAIDKLGKAGIAVDLAS 91 Query: 349 -------IDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKN 401 A G +E + + ++ L + + K Sbjct: 92 ATASPPMWLTQAHPEVLWKDERGDTVWPGAREHW--RPTSPVFREYALNLCRRMAEHYKG 149 Query: 402 HPSVVMWSIANE--PDTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAH-TDTISD 458 +P VV W ++NE R + + + +K T I VN + A ++D Sbjct: 150 NPYVVAWHVSNEYGCHNRFDYSDDAMRAFQKWCKKRYKT--IDAVNEAWGTAFWAQHMND 207 Query: 459 LFDVLCLNRYYG 470 +++ RY G Sbjct: 208 FSEIIPP-RYIG 218 >4JIE-A nrPDB Length = 503 Score = 35.5 bits (80), Expect = 0.076, Method: Composition-based stats. Identities = 23/121 (19%), Positives = 43/121 (35%), Gaps = 13/121 (10%) Query: 482 EKVLEKELLAWQEKLHQP-IIITEYGVDTLAGLHSMYTDMWS--EEYQCAWLDMYHRVFD 538 + K + +E P +I++E G+D + + Y ++ + D Sbjct: 386 PWGINKAVTYVKETYGNPTMILSENGMDQPGNVSITQGVHDTVRIRYYRNYITELKKAID 445 Query: 539 RVSAVVGEQVWNFADFATSQGILRVGGNKK-GIFTRD-----RKPKSAAFLLQKRWTGMN 592 + V+G W+ D R+G + GI D R PK +AF + + Sbjct: 446 DGAKVIGYFAWSLLD----NFEWRLGYTSRFGIVYVDYKTLKRYPKDSAFWFKNMLSSKK 501 Query: 593 F 593 Sbjct: 502 R 502 >4ZEN-A nrPDB Length = 485 Score = 35.1 bits (79), Expect = 0.093, Method: Composition-based stats. Identities = 28/127 (22%), Positives = 44/127 (34%), Gaps = 8/127 (6%) Query: 477 DLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLH--SMYTDMWSEEYQCAWLDMYH 534 D L L + PI+ITE G+ L + D + +Y + Sbjct: 358 DWAIDPVGLRIGLRRIANRYQLPILITENGLGEFDTLEPGDIVNDDYRIDYLRRHVQEIQ 417 Query: 535 RVFDRVSAVVGEQVWNFADFAT-SQGILRVGG----NKKGIFTRD-RKPKSAAFLLQKRW 588 R V+G W+F D + G + G N+ +D R+ K +F +R Sbjct: 418 RAITDGVDVLGYCAWSFTDLLSWLNGYQKRYGFVYVNRDDESEKDLRRIKKKSFYWYQRV 477 Query: 589 TGMNFGE 595 N E Sbjct: 478 IETNGAE 484 >4K68-A nrPDB Length = 379 Score = 35.1 bits (79), Expect = 0.100, Method: Composition-based stats. Identities = 47/301 (15%), Positives = 107/301 (35%), Gaps = 68/301 (22%) Query: 330 HYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHL 389 H+ A++ +++ ++H + + VG NL PKE++ E+ +++A Sbjct: 92 HWEAADKFVEFGEKHKMYI------VGHNLVWHSQV-----PKEVFLNESGGTISKEALT 140 Query: 390 QAIKELIA----RDKNHPSVVMWSIANEPDTRPQG----------AREYFAPLAEATRKL 435 +++ IA R K + W + NE ++ A ++ Sbjct: 141 AKMQDHIATLAGRYKGR--IQAWDVVNEAVEDDGSWRKSPWYNIMGEDFIAKAFTMAHEV 198 Query: 436 DPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWY--------------VQSGDLETA 481 DP ++++ D +T++ ++ + + + + ++ Sbjct: 199 DPK-----AHLIYNDYNTESPIKRNFIVGMIKNFKKQGVPIHGVGMQEHLAIDGPSVDEI 253 Query: 482 EKVL----EKELLAWQEKLHQPIIIT-------------EYGVDTLAGLHSMYTDMWSEE 524 EK L + + A +L ++ + EY + + + DM EE Sbjct: 254 EKTLIALADAGVRAHITELDIDVLPSVWNLPTAEVSTRFEYKPERDPYIQGLPKDM--EE 311 Query: 525 YQCAWLDMYHRV-FDRVSAVVGEQVWNFADFAT--SQGILRVGGNKKGIFTRDRKPKSAA 581 + ++ + +W AD T + ++ N +F R++KPK A Sbjct: 312 KLAKRYEDIFKIYLKHRDKIERVTLWGTADNETWLNDFPIKGRTNYPLLFDRNQKPKPAY 371 Query: 582 F 582 F Sbjct: 372 F 372 >3PTM-A nrPDB Length = 505 Score = 35.1 bits (79), Expect = 0.100, Method: Composition-based stats. Identities = 33/121 (27%), Positives = 42/121 (34%), Gaps = 14/121 (11%) Query: 478 LETAEKVLEKELLAWQEKLHQPII-ITEYGVDTLAG----LHSMYTDMWSEEYQCAWLDM 532 L + LL +E P + ITE GVD L D EY L Sbjct: 385 LYVYPQGFRDLLLYVKENYGNPTVYITENGVDEFNNKTLPLQEALKDDARIEYYHKHLLS 444 Query: 533 YHRVFDRVSAVVGEQVWNFAD-FATSQG-ILRVGGN----KKGIFTRDRKPKSAAFLLQK 586 + V G W+ D F S G +R G N G R R PK++A +K Sbjct: 445 LLSAIRDGANVKGYFAWSLLDNFEWSNGYTVRFGINFVDYNDG---RKRYPKNSAHWFKK 501 Query: 587 R 587 Sbjct: 502 F 502 >4QP0-A nrPDB Length = 359 Score = 35.1 bits (79), Expect = 0.10, Method: Composition-based stats. Identities = 32/200 (16%), Positives = 68/200 (34%), Gaps = 37/200 (18%) Query: 356 GFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARD--------KNHPSVVM 407 + G+ + N + + N E + + I ++ R+ K+ P++ Sbjct: 110 NWEDYGGMDYYVKNFGGTYHDDFYTNTEMIDSFKEYISHVLNRENSLTGVKYKDDPTIFG 169 Query: 408 WSIANEPDTRPQG------------AREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDT 455 W IANEP G + ++E + +D + + F + ++ Sbjct: 170 WEIANEPRCVGSGDFPASSNCSTTVTTAWIKEISEYIKSIDSNHLVAVGDEGFFNRKGES 229 Query: 456 ISDL----------------FDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQP 499 + D + Y + + D + + + K+ A Q +P Sbjct: 230 DYEYNGGSGMDFDAILALSSIDFGTFHLYPEAWSKGTDSSWSVQWI-KDHAAAQADADKP 288 Query: 500 IIITEYGVDTLAGLHSMYTD 519 +I+ EYG+ T A + Y Sbjct: 289 VIMEEYGLSTDALRVAQYPV 308 >5A94-A nrPDB Length = 365 Score = 34.7 bits (78), Expect = 0.10, Method: Composition-based stats. Identities = 31/166 (18%), Positives = 58/166 (34%), Gaps = 33/166 (19%) Query: 274 VAVKGEQFLIN-HKPFYFTGFGRHEDADLRGKGFDNVLMVHDH--ALMDWIGANSYRTSH 330 ++VKG +F+ + K F F G GK L + G N+ R Sbjct: 51 ISVKGNKFIDDKGKTFTFRGVNI----ADTGKLLSRNQWQKSLFEELANNWGVNTIRLPI 106 Query: 331 YP-------------YAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSE 377 +P + +E + WA++ GI +I + + + + Sbjct: 107 HPVSWRKLGPDVYLGHIDEAVRWANDLGIYLI-------------LDWHSIGYLPTEQYQ 153 Query: 378 EAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQGARE 423 + T + + + R +N P+V ++ + NEP T E Sbjct: 154 HPMYDTTIKETRDFWRRITFRYQNVPTVAVYELFNEPTTMGNTLGE 199 >6IAA-A nrPDB Length = 859 Score = 34.7 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 19/103 (18%), Positives = 37/103 (35%), Gaps = 10/103 (9%) Query: 483 KVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSA 542 + ++KEL +LH P+++T + W+ + Q ++ Y ++ + S Sbjct: 618 RQVQKELGDVLVRLHNPVVLTP----------TTVQVTWTVDRQPQFIQGYRVMYRQTSG 667 Query: 543 VVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQ 585 + W D V N K T + K + Q Sbjct: 668 LQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQ 710 >4TUF-A nrPDB Length = 346 Score = 34.7 bits (78), Expect = 0.13, Method: Composition-based stats. Identities = 33/158 (20%), Positives = 46/158 (29%), Gaps = 37/158 (23%) Query: 285 HKPFYFTGF-------GRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEM 337 K G G H L + M M +G N+ R P+ Sbjct: 14 GKVVQLKGVNVFGFETGNHVMHGL--WARNWKDM---IVQMQGLGFNAVRL---PFCPAT 65 Query: 338 LDW------------ADEHGIV-------VIDETAAVGFNLSLGIGFEAGNKPKELYSEE 378 L AD G+ VI E A G + L EL+ Sbjct: 66 LRSDTMPASIDYSRNADLQGLTSLQILDKVIAEFNARGMYVLLDHHTPDCAGISELWY-- 123 Query: 379 AVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDT 416 T+ L ++ + R KN P V+ + NEP Sbjct: 124 -TGSYTEAQWLADLRFVANRYKNVPYVLGLDLKNEPHG 160 >1RHI-3 nrPDB Length = 236 Score = 34.7 bits (78), Expect = 0.13, Method: Composition-based stats. Identities = 17/61 (27%), Positives = 28/61 (45%), Gaps = 4/61 (6%) Query: 35 WESALQESRAIAVPGSFNDQF--ADADIRNYAG--NVWYQREVFIPKGWAGQRIVLRFDA 90 W+ LQ + + +P + QF D D AG + WY + +P +GQ +L F + Sbjct: 153 WDIGLQSTIVMTIPWTSGVQFRYTDPDTYTSAGYLSCWYLTSLILPPQTSGQVYLLSFIS 212 Query: 91 V 91 Sbjct: 213 A 213 >4B3K-A nrPDB Length = 479 Score = 34.3 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 29/168 (17%), Positives = 56/168 (33%), Gaps = 28/168 (16%) Query: 444 VNVMFCDAHTDTISDLFD---VLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQ-- 498 V+ + + + D V+ + WY + ++K + E ++ Sbjct: 290 VDYLGLNFYHPKRVKAPDAIPVISPSWSPEWYYDPYLMPGRRMNVDKGWEIYPEAVYDIA 349 Query: 499 ----------PIIITEYGV-----DTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAV 543 P ++E GV D D + ++ L H+ + S Sbjct: 350 IKMRDHYDNIPWFLSENGVGISGEDRYRDETGQIQDDYRIQFLKEHLTYLHKGIEAGSNC 409 Query: 544 VGEQVWNFADFATSQGILRVGGNKKGIF-----TRDRKPKSAAFLLQK 586 G VW D L N+ G+ T+ R+PK++A+ +K Sbjct: 410 FGYHVWTPID---GWSWLNAYKNRYGLVENNIHTQVRRPKASAYWFKK 454 >3VIK-A nrPDB Length = 487 Score = 34.3 bits (77), Expect = 0.15, Method: Composition-based stats. Identities = 27/116 (23%), Positives = 44/116 (37%), Gaps = 16/116 (13%) Query: 478 LETAEKVLEKELLAWQEKLHQP-IIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRV 536 L+ KEL + + + P + ITE G GL+ + Y +M + Sbjct: 356 LKVVPWGFRKELNWIKNEYNNPPVFITENGFSDYGGLNDTGRVHY---YTEHLKEMLKAI 412 Query: 537 FDRVSAVVGEQVWNFADFATSQGILRVGGNKK-GIFTRD-------RKPKSAAFLL 584 + V+G W+ D G ++K GI+ D R PK +A +L Sbjct: 413 HEDGVNVIGYTAWSLMD----NFEWLRGYSEKFGIYAVDFEDPARPRIPKESAKVL 464 >4U5I-A nrPDB Length = 403 Score = 34.3 bits (77), Expect = 0.15, Method: Composition-based stats. Identities = 35/203 (17%), Positives = 70/203 (34%), Gaps = 30/203 (14%) Query: 325 SYRTSHYPY--AEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNG 382 + RT YPY + LD ++ + SL GF + Sbjct: 133 TMRT--YPYTIDKAFLDRVEQV------------VDWSLSRGFVTIINSHHDDWIKEDYN 178 Query: 383 ETQQAHLQAIKELIARDKNHPSVVMWSIANEPDT--RPQGAREYFAPLAEATRKLDPTRP 440 + + +++ R KN +++ I NEP + + + + + RK +PTR Sbjct: 179 GNIERFEKIWEQIAERFKNKSENLLFEIMNEPFGNITDEQIDDMNSRILKIIRKTNPTRI 238 Query: 441 ITCVNVMFCDAHTDTISDLFD---VLCLNRYY-------GWYVQSGDLETAEKVLE--KE 488 + + +T + D ++ YY W G E + V+ Sbjct: 239 VIIGGGYWNSYNTLVNIKIPDDPYLIGTFHYYDPYEFTHKWRGTWGTQEDMDTVVRVFDF 298 Query: 489 LLAWQEKLHQPIIITEYGVDTLA 511 + +W ++ + P+ + V A Sbjct: 299 VKSWSDRNNIPVYFGAFAVMAYA 321 >5CG0-A nrPDB Length = 489 Score = 34.3 bits (77), Expect = 0.16, Method: Composition-based stats. Identities = 27/128 (21%), Positives = 50/128 (39%), Gaps = 7/128 (5%) Query: 478 LETAEKVLEKELLAWQEKLHQPII-ITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRV 536 L A + L ++P+ ITE G T + D +Y A ++ Sbjct: 352 LTLAPNSIHTALTHLNNLYNKPVFYITENGWSTDESRENSLIDDDRIQYYRASMESLLNC 411 Query: 537 FDRVSAVVGEQVWNFAD-FATSQGILRVGGNKKGIFT---RDRKPKSAAFLLQK--RWTG 590 D + G W+ D F +G + G + F+ R R P+ AAF+ + + Sbjct: 412 LDDGINLKGYMAWSLMDNFEWMEGYIERFGLYEVDFSDPARTRTPRKAAFVYKHIIKHRV 471 Query: 591 MNFGEKPQ 598 +++ +P+ Sbjct: 472 VDYEYEPE 479 >6IK8-B nrPDB Length = 718 Score = 34.3 bits (77), Expect = 0.17, Method: Composition-based stats. Identities = 16/63 (25%), Positives = 24/63 (38%), Gaps = 6/63 (9%) Query: 68 WYQREVFIPKGWAGQRIVLRFDAVTH-YGKVWVNNQEVMEHQGGYTPFEADVTPYVIAGK 126 WY+ P G L D + G++W+N + V H GY + D + AG Sbjct: 601 WYKATFNAP----GGNDPLALDMASMGKGQIWINGEGVGRHWPGYIA-QGDCSKCSYAGT 655 Query: 127 SVR 129 Sbjct: 656 FNE 658 Score = 33.9 bits (76), Expect = 0.20, Method: Composition-based stats. Identities = 41/282 (14%), Positives = 79/282 (28%), Gaps = 57/282 (20%) Query: 22 SLDRENCGIDQRWWESALQ---ESRAIAVPGSFNDQFADADIRNYAGNVWYQREVFIPKG 78 + G+ + + +S + G + + D +Y +WY V I Sbjct: 406 KMTPAGGGLSWQSYNEETPTADDSDTLTANGLWEQKNVTRDSSDY---LWYMTNVNIASN 462 Query: 79 W----AGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTPYVIAGKSVRITVCV 134 G+ L + H V+VN + G P + +V++ + Sbjct: 463 EGFLKNGKDPYLTVMSAGHVLHVFVNGKLSGTVYGTLD------NPKLTYSGNVKLRAGI 516 Query: 135 NNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTPNTWVDDITVVTHVA 194 N G +D +N AG+ V L + Sbjct: 517 NKISLLSV---------SVGLPNVGVHYDTWN-AGVLGPVTLSGLNEG-----------S 555 Query: 195 QDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVVNPHLWQPGEGYLYELCV 254 ++ ++V G+ + V +G+ + P W Y+ Sbjct: 556 RNLAKQKWSYKVGLKGESLSLHSLSGSSSVEWVRGSL--MAQKQPLTW-------YKATF 606 Query: 255 TAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRH 296 A + + ++ Q IN + G GRH Sbjct: 607 NAPGGN------DPLALDMASMGKGQIWINGE-----GVGRH 637 >5Z6P-A nrPDB Length = 765 Score = 33.9 bits (76), Expect = 0.20, Method: Composition-based stats. Identities = 17/96 (17%), Positives = 32/96 (33%), Gaps = 15/96 (15%) Query: 460 FDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEY--GVDTLAGLHSMY 517 DV+ N Y ++ L E ++ + P II E+ G H+ Sbjct: 637 VDVVSYNYY-------------KEGLHPEPWSFLADIDMPSIIGEFHFGALDSGFFHAGL 683 Query: 518 TDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFAD 553 S++ + + Y + VG + + D Sbjct: 684 VTACSQQERGQMFERYMQTVVDNPYFVGAHYFQYID 719 >1G01-A nrPDB Length = 364 Score = 33.5 bits (75), Expect = 0.25, Method: Composition-based stats. Identities = 32/176 (18%), Positives = 56/176 (31%), Gaps = 48/176 (27%) Query: 285 HKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHY---------PYAE 335 P G H G+ + AL + G+N R + Y P + Sbjct: 34 GTPVQLRGMSTHGLQWF-GEIVNENAF---VALSNDWGSNMIRLAMYIGENGYATNPEVK 89 Query: 336 EML----DWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQA 391 +++ + A EH + VI + + + + + E A + + Sbjct: 90 DLVYEGIELAFEHDMYVI---VDWHVHAPGDPRADVYSGAYDFFEEIADHYKDHP----- 141 Query: 392 IKELIARDKNHPSVVMWSIANEPDTRPQGA-------------REYFAPLAEATRK 434 KNH ++W +ANEP G +EY P+ E R+ Sbjct: 142 --------KNH--YIIWELANEPSPNNNGGPGLTNDEKGWEAVKEYAEPIVEMLRE 187 >4HA4-A nrPDB Length = 489 Score = 33.5 bits (75), Expect = 0.27, Method: Composition-based stats. Identities = 28/125 (22%), Positives = 50/125 (40%), Gaps = 26/125 (20%) Query: 469 YGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCA 528 +GW E + L L + ++ H P+++TE G+ G + + S YQ Sbjct: 356 FGW-------EFYPEGLYNVLKEYWDRYHLPLLVTENGI-ADEGDYQRPYYLVSHVYQV- 406 Query: 529 WLDMYHRVFDRVSAVVGEQVWNFAD-------FATSQGILRVGGNKKGIFTRDRKPKSAA 581 HR V+G W+ AD F+ G+L V + K + + +A Sbjct: 407 -----HRALQDGVNVIGYLHWSLADNYEWASGFSKRFGLLMVDYSTKRL-----HWRPSA 456 Query: 582 FLLQK 586 F+ ++ Sbjct: 457 FIYRE 461 >2X5I-C nrPDB Length = 238 Score = 33.5 bits (75), Expect = 0.27, Method: Composition-based stats. Identities = 15/67 (22%), Positives = 25/67 (37%), Gaps = 4/67 (5%) Query: 35 WESALQESRAIAVPGSFNDQFADADIRNYAG----NVWYQREVFIPKGWAGQRIVLRFDA 90 W+ LQ S + +P + Y WYQ + +P G + +VL F + Sbjct: 156 WDIGLQSSCVLCIPWISQTHYRLVQQDEYTSAGNVTCWYQTGIVVPPGTPNKCVVLCFAS 215 Query: 91 VTHYGKV 97 + V Sbjct: 216 ACNDFSV 222 >3ZJ8-A nrPDB Length = 532 Score = 33.5 bits (75), Expect = 0.30, Method: Composition-based stats. Identities = 35/208 (16%), Positives = 65/208 (31%), Gaps = 50/208 (24%) Query: 421 AREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLET 480 +Y + E + P F ++ + +D + +N Y YV + Sbjct: 307 TGDYPKSMRELVKGRLPK---------FSADDSEKLKGCYDFIGMNYYTATYVTNAVKSN 357 Query: 481 AEKVL---EKELLAWQEKLHQPIIITEYGVDTLA---GLHSM---------YTDMWSEEY 525 +EK+ + ++ E+ +PI YG GL+ + ++ E Sbjct: 358 SEKLSYETDDQVTKTFERNQKPIGHALYGGWQHVVPWGLYKLLVYTKETYHVPVLYVTES 417 Query: 526 --------------------QCAWLDMYHR----VFDRVSAVVGEQVWNFAD-FATSQG- 559 + + + D V G VW+F D F + G Sbjct: 418 GMVEENKTKILLSEARRDAERTDYHQKHLASVRDAIDDGVNVKGYFVWSFFDNFEWNLGY 477 Query: 560 ILRVGGNKKGIFTRDRKPKSAAFLLQKR 587 I R G + +R PK +A + Sbjct: 478 ICRYGIIHVDYKSFERYPKESAIWYKNF 505 >5E9A-A nrPDB Length = 712 Score = 33.1 bits (74), Expect = 0.33, Method: Composition-based stats. Identities = 12/89 (13%), Positives = 31/89 (34%), Gaps = 1/89 (1%) Query: 417 RPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHTD-TISDLFDVLCLNRYYGWYVQS 475 + + + +P P T + + + + ++ + D + + Y W+ + Sbjct: 251 NTDQVTRFCSEEIRPLKAENPALPATTNFMEYFNDYDYWKLAGVLDFISWDSYPMWHTRQ 310 Query: 476 GDLETAEKVLEKELLAWQEKLHQPIIITE 504 D+ A L K +P ++ E Sbjct: 311 DDIGLAAYTAMYHDLMRTLKQGKPFVLME 339 Score = 31.2 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 23/160 (14%), Positives = 46/160 (28%), Gaps = 28/160 (17%) Query: 307 DNVLMVHDHALMDWIGANSYRTSHYPYA-------EEMLDWAD-------EHGIVVIDET 352 ++V D +M N + ++ DW D E+GI V T Sbjct: 53 HPDVLVRDVEMMKEARCNVMSVGIFSWSALEPEEGRYTFDWMDQVLNRLHENGISVFLAT 112 Query: 353 AAVGFNLSLGIGFEA---------GNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHP 403 + + + ++ + ++ +L R +HP Sbjct: 113 PSGARPAWMSQKYPQVLRVGRDRVPALHGGRHNHCMSSPVYREKVQLMNGQLAKRYAHHP 172 Query: 404 SVVMWSIANEPDTRPQGAREYFAPLAEATRKLDPTRPITC 443 +V+ W I+NE + + R +T Sbjct: 173 AVIGWHISNEYGGECH-CDTCQGQFRDWLKA----RYVTL 207 >1PBG-A nrPDB Length = 468 Score = 33.1 bits (74), Expect = 0.34, Method: Composition-based stats. Identities = 23/97 (23%), Positives = 41/97 (42%), Gaps = 11/97 (11%) Query: 497 HQPIIITEYGVD-TLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFAD-F 554 ++ I ITE G+ + + D +Y L++ + V G +W+ D F Sbjct: 368 YKKIYITENGLGYKDEFVDNTVYDDGRIDYVKQHLEVLSDAIADGANVKGYFIWSLMDVF 427 Query: 555 ATSQGILRVGGNKKGIF-----TRDRKPKSAAFLLQK 586 + S G + G+F T++R PK +A +K Sbjct: 428 SWSNGYEKRY----GLFYVDFDTQERYPKKSAHWYKK 460 >1ND3-C nrPDB Length = 238 Score = 33.1 bits (74), Expect = 0.37, Method: Composition-based stats. Identities = 16/58 (27%), Positives = 23/58 (39%), Gaps = 4/58 (6%) Query: 35 WESALQESRAIAVPGSFNDQ--FADADIRNYAG--NVWYQREVFIPKGWAGQRIVLRF 88 W+ LQ + ++ VP Q F D + AG WYQ +P +L F Sbjct: 155 WDVGLQSTVSLVVPWISASQYRFTTPDTYSSAGYITCWYQTNFVVPPNTPNTAEMLCF 212 >4TLZ-A nrPDB Length = 443 Score = 32.8 bits (73), Expect = 0.42, Method: Composition-based stats. Identities = 35/185 (18%), Positives = 57/185 (30%), Gaps = 24/185 (12%) Query: 326 YRTSH-YPYAEEMLDWADEHGIVVIDETAA---VGFNLSLGIGFEAGNKPKELYSEEAVN 381 R H + +G VV D T + ++ F+ + K+ + N Sbjct: 233 VRFLHDNRPDTVVHAIMPSYGYVVADNTPFANQIFDPAAVDDYFDGSKQAKDAFWRYHRN 292 Query: 382 GETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQGAREYFAPLAEATRKLDPTRPI 441 + I++L R + +E P+ A + A R D TR Sbjct: 293 TNYSVVDDEVIRDLYRRGYD----------DEVAGAPRLNFVNLAHVVGAKRIADDTRVT 342 Query: 442 TCVNVMFCDAHTDTISDLFDV-LCLNRYYGWYVQSGDL--ETAEKVLEKELLAWQEKLHQ 498 D DV +C Y + GDL E AE ++ WQ Sbjct: 343 VYSMAREESYDLD-----VDVLVCATGYDP--MDPGDLLGELAEHCVQDAEGRWQVDRDY 395 Query: 499 PIIIT 503 ++ T Sbjct: 396 RMVTT 400 >4MAD-A nrPDB Length = 600 Score = 32.8 bits (73), Expect = 0.44, Method: Composition-based stats. Identities = 20/106 (18%), Positives = 39/106 (36%), Gaps = 9/106 (8%) Query: 64 AGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVM--EHQGGYTPFEADVTPY 121 G + Y+ + KG G++ L + G+V+VN + V E G + ++T Sbjct: 393 YGFIVYETTI---KGAYGKQ-ALTVQDIHDRGQVYVNGEYVGIVERNRGCSRLVVELTE- 447 Query: 122 VIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNY 167 ++I V +N+ E + + D+ Y Sbjct: 448 --EESKLQIIVENMGRINYGPFVVDYKGITEGVRLGNQFLFDWTVY 491 >5BX9-A nrPDB Length = 416 Score = 32.8 bits (73), Expect = 0.51, Method: Composition-based stats. Identities = 39/215 (18%), Positives = 75/215 (34%), Gaps = 25/215 (11%) Query: 393 KELIARDKNHPSVVMWSIANEPD----TRPQGAREYFAPLAEAT----RKLDPTRPITCV 444 + + + +PSV W + NEP+ RP+ E +A L +A+ R +DP +P+ Sbjct: 119 RRMAMLSQRYPSVAAWQVWNEPNLIGFWRPKADPEGYAKLLQASTIALRMVDPEKPVVSA 178 Query: 445 NVMFCDAHTD--TISDLFDVLCLNRY--YGWYVQSGDLETAEKVLEKELLAWQEKLHQ-- 498 + F D T+ D L + Y L + ++ ++++ Sbjct: 179 GMAFFSEMPDGRTMFDALGHLGVESLGTIATYHPYTQLPEGNYPWNLDFVSHANQINRAL 238 Query: 499 -----PIII-TEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFA 552 P I TE+G G + + E Q ++ + + ++ + Sbjct: 239 RNAGVPAIWSTEWGWSAYKGPKELQDIIGVEG-QADYVLRRLALMSALDYDR-IFLFTLS 296 Query: 553 DFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKR 587 D + G+ D PK LQ+ Sbjct: 297 DLDQRASVRDRDY---GLLDLDANPKPVYLALQRF 328 >5WH8-A nrPDB Length = 323 Score = 32.4 bits (72), Expect = 0.61, Method: Composition-based stats. Identities = 56/321 (17%), Positives = 100/321 (31%), Gaps = 72/321 (22%) Query: 285 HKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYA---------- 334 KP G H A + L AL+ + +R + Y + Sbjct: 26 GKPVQLRGMSSHGLAWFPKCYTEASLT----ALVKDWNIDIFRLAIYTHEWGGYTTNQWK 81 Query: 335 ---------EEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQ 385 + M+D + GI I + + + P + + Sbjct: 82 SKDDYNAYIDNMVDICAKLGIYCI---------IDWHVLNDGSGDPNYTLDDAIPFWDYM 132 Query: 386 QAHLQAIKELIARDKNHPSVVMWSIANEPDTRP---QGAREYFAPLAEATRKLDPTRPIT 442 A + DK H V++ I NEP+ +EY + RK DP + I Sbjct: 133 SAKHKD-------DK-H---VLYEICNEPNGFDVKWADVKEYAEAVIPVIRKNDPDKIII 181 Query: 443 CVNVMFCDAHTDTISD--LFDVLCLN-RYYGWYVQSGDLETAEKVLEKELLAWQEKLHQP 499 C + D +D + +Y + A+ + K L Sbjct: 182 CGTPTWSQDVDLAAQDPLSYDNVMYTLHFYSGTHTQYLRDKAQVAINKGLA--------- 232 Query: 500 IIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATSQG 559 + +TE+G +G ++ +E W+D ++S V W+FAD S Sbjct: 233 LFVTEFGTTQASG----DGGVYFDECNT-WMDWMDA--RKISWVN----WSFADKPESSA 281 Query: 560 ILRVGGNKKG---IFTRDRKP 577 L+ G + G + + + Sbjct: 282 ALKPGASNSGDWNMVSESGQY 302 >5UC7-A nrPDB Length = 431 Score = 32.0 bits (71), Expect = 0.85, Method: Composition-based stats. Identities = 11/46 (23%), Positives = 19/46 (41%) Query: 322 GANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLSLGIGFEA 367 GA R H + + + D GI++I + A GF + + Sbjct: 218 GAGGMRIYHPQWLQRIRQMCDREGILLIADEIATGFGRTGRLFACE 263 >4L4P-A nrPDB Length = 345 Score = 31.6 bits (70), Expect = 0.95, Method: Composition-based stats. Identities = 18/62 (29%), Positives = 24/62 (38%), Gaps = 3/62 (4%) Query: 524 EYQCAWLDMYHRVFDRV-SAVVGEQVWNFADFATSQGILRVGGNKKG--IFTRDRKPKSA 580 E Q + RVF + +W +D T + V G K +F D KPK A Sbjct: 271 ELQAKVYEDVFRVFREYRDVITSVTLWGISDRHTWKDNFPVIGRKDWPLLFDIDGKPKKA 330 Query: 581 AF 582 F Sbjct: 331 FF 332 >2O2Y-A nrPDB Length = 349 Score = 31.6 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 25/146 (17%), Positives = 49/146 (33%), Gaps = 13/146 (8%) Query: 358 NLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTR 417 L F+ N E Q ++ + LI + ++++ S+AN Sbjct: 81 MLPFDASFDTANDIDEETKNNKRYNMLQNYTIEDVANLIHQKYGKINMLVHSLAN----- 135 Query: 418 PQGAREYFAPLAEATRK--LDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYV-- 473 A+E L +RK LD + + C + + ++ L + V Sbjct: 136 ---AKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVP 192 Query: 474 -QSGDLETAEKVLEKELLAWQEKLHQ 498 G + +A+ LE + L + Sbjct: 193 GYGGGMSSAKAALESDTRVLAYHLGR 218 >3WDP-P nrPDB Length = 473 Score = 31.6 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 27/135 (20%), Positives = 45/135 (33%), Gaps = 26/135 (19%) Query: 469 YGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCA 528 +GW E + LE L P+IITE G+ + D + Y + Sbjct: 345 FGW-------EMYPEGLENLLKYLNNAYELPMIITENGM-------ADAADRYRPHYLVS 390 Query: 529 WLDMYHRVFDRVSAVVGEQVWNFAD-------FATSQGILRVGGNKKGIFTRDRKPKSAA 581 L + + V G W+ D F G++ V K R + +A Sbjct: 391 HLKAVYNAMKEGADVRGYLHWSLTDNYEWAQGFRMRFGLVYVDFETK-----KRYLRPSA 445 Query: 582 FLLQKRWTGMNFGEK 596 + ++ T E+ Sbjct: 446 LVFREIATQKEIPEE 460 >5VAQ-A nrPDB Length = 954 Score = 31.2 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 14/52 (26%), Positives = 23/52 (44%), Gaps = 10/52 (19%) Query: 542 AVVGEQVWNFAD-------FATSQGILRVGGNKKGIFTRDRKPKSAAFLLQK 586 V G W+ D + +G+ V N K ++RKPKS+A ++ Sbjct: 424 RVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSK---QKERKPKSSAHYYKQ 472 >1QOX-A nrPDB Length = 449 Score = 31.2 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 37/194 (19%), Positives = 57/194 (29%), Gaps = 42/194 (21%) Query: 423 EYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRY--------YGWYVQ 474 EY + + L PI D + I D + +N Y G Sbjct: 257 EYPKFMLDWYENLGYKPPI-------VDGDMELIHQPIDFIGINYYTSSMNRYNPGEAGG 309 Query: 475 SGDLETAEKVLEKELLAWQ--------------EKLHQP-IIITEYGVDTLAGLH--SMY 517 E K + W+ +K P + ITE G GL Sbjct: 310 MLSSEAISMGAPKTDIGWEIYAEGLYDLLRYTADKYGNPTLYITENGACYNDGLSLDGRI 369 Query: 518 TDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFAD-FATSQGILRVGGNKKGIFTRD-- 574 D +Y L R + + G W+ D F ++G G + G+ D Sbjct: 370 HDQRRIDYLAMHLIQASRAIEDGINLKGYMEWSLMDNFEWAEG----YGMRFGLVHVDYD 425 Query: 575 ---RKPKSAAFLLQ 585 R PK + + + Sbjct: 426 TLVRTPKDSFYWYK 439 >3TTS-A nrPDB Length = 675 Score = 30.8 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 10/19 (52%), Positives = 14/19 (73%) Query: 395 LIARDKNHPSVVMWSIANE 413 L R K+HP +VMW ++NE Sbjct: 132 LAERYKDHPQIVMWHVSNE 150 >6ACY-C nrPDB Length = 240 Score = 30.8 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 13/64 (20%), Positives = 23/64 (35%), Gaps = 7/64 (10%) Query: 35 WESALQESRAIAVP----GSFNDQFADADIRNYAG---NVWYQREVFIPKGWAGQRIVLR 87 W+ LQ S ++ +P F + Y +WYQ +P G+ ++ Sbjct: 155 WDFGLQSSVSLVIPWISNTHFRTAKTGGNYDYYTAGVVTLWYQTNYVVPPETPGEAYIIA 214 Query: 88 FDAV 91 A Sbjct: 215 MGAA 218 >6HBG-C nrPDB Length = 239 Score = 30.8 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 16/67 (23%), Positives = 23/67 (34%), Gaps = 4/67 (5%) Query: 35 WESALQESRAIAVP----GSFNDQFADADIRNYAGNVWYQREVFIPKGWAGQRIVLRFDA 90 W+ LQ S + VP + D WYQ + +P G VL F + Sbjct: 157 WDIGLQSSCVLCVPWISQSHYRMVQQDPYTSAGYITCWYQTNIVVPPGAPTSCDVLCFAS 216 Query: 91 VTHYGKV 97 + V Sbjct: 217 ACNDFSV 223 >1XC6-A nrPDB Length = 971 Score = 30.4 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 18/92 (19%), Positives = 34/92 (36%), Gaps = 6/92 (6%) Query: 59 DIRNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYG-KVWVNNQEVMEHQGGYTPFEAD 117 D + G + ++ + ++ T YG +W+N V G + Sbjct: 683 DYGYHTGALLFRGHFT--ANGKEKTFFVQTKGGTAYGHSIWINETYVGSWAGTSINDNNN 740 Query: 118 VT---PYVIAGKSVRITVCVNNELNWQTIPPG 146 T P + +GK+ ITV ++N + G Sbjct: 741 ATYTLPTLQSGKNYVITVVIDNMGLDEDWTIG 772 >5GSM-A nrPDB Length = 786 Score = 30.4 bits (67), Expect = 2.2, Method: Composition-based stats. Identities = 23/126 (18%), Positives = 35/126 (27%), Gaps = 31/126 (24%) Query: 273 SVAVKGEQFLINHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYRTS--- 329 V G++++I+ +P G R M G N+ T Sbjct: 3 KVEFSGKRYVIDGEPVTIAGGTL---QFFR---VPADAWKDRLLKMREAGLNTVDTYVAW 56 Query: 330 --HYPY----------AEE-----MLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPK 372 H P + L+ ADE G VI + + + G P Sbjct: 57 NWHEPEKGSFDFKGETHPQRNLVGFLELADELGFYVI-----IRPGPYICGEWRNGGIPD 111 Query: 373 ELYSEE 378 L E Sbjct: 112 WLIDEH 117 >4RNX-A nrPDB Length = 400 Score = 30.4 bits (67), Expect = 2.2, Method: Composition-based stats. Identities = 19/67 (28%), Positives = 30/67 (44%), Gaps = 4/67 (5%) Query: 500 IIITEYGV--DTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATS 557 +IITE G AG + +WSEE W +++ + ++ S V Q+W A Sbjct: 315 MIITE-GAFISPQAGGYDNAPGVWSEEQMVEWTKIFNAIHEKKSFVW-VQLWVLGWAAFP 372 Query: 558 QGILRVG 564 + R G Sbjct: 373 DNLARDG 379 >6IGZ-9 nrPDB Length = 222 Score = 30.4 bits (67), Expect = 2.3, Method: Composition-based stats. Identities = 17/70 (24%), Positives = 26/70 (37%), Gaps = 14/70 (20%) Query: 9 TREIKKLDGLWAFSLDRENC-----GIDQRWWESALQESRAIAVPGSFNDQFADA----- 58 RE +K++G WA + GI WWE + +P FN A Sbjct: 73 YREAEKVNGRWAMNAVAGIVFCELLGIQTNWWEVGQNPDLPVDLP--FNALVAIEAVIMG 130 Query: 59 --DIRNYAGN 66 +++ Y G Sbjct: 131 FFEVKRYQGW 140 >5JBO-A nrPDB Length = 485 Score = 30.4 bits (67), Expect = 2.4, Method: Composition-based stats. Identities = 24/116 (20%), Positives = 38/116 (32%), Gaps = 7/116 (6%) Query: 478 LETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYH--- 534 L + + K L +PI ITE G + ++ ++ + D + Sbjct: 358 LRSCPDMFRKHLARVHGLYGKPIYITENGCPCPGEDKMTCEEAINDPFRIQYFDSHLDSI 417 Query: 535 --RVFDRVSAVVGEQVWNFAD-FATSQG-ILRVGGNKKGIFTRDRKPKSAAFLLQK 586 + V G W D S G R G T R PK +A +L+ Sbjct: 418 SKAISQDGVVVKGYFAWALLDNLEWSDGYGPRFGVTYTDYTTLKRTPKKSALVLKD 473 >4RNU-A nrPDB Length = 400 Score = 30.4 bits (67), Expect = 2.5, Method: Composition-based stats. Identities = 19/67 (28%), Positives = 30/67 (44%), Gaps = 4/67 (5%) Query: 500 IIITEYGV--DTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVWNFADFATS 557 +IITE G AG + +WSEE W +++ + ++ S V Q+W A Sbjct: 166 MIITE-GAFISPQAGGYDNAPGVWSEEQMVEWTKIFNAIHEKKSFVW-VQLWVLGWAAFP 223 Query: 558 QGILRVG 564 + R G Sbjct: 224 DNLARDG 230 >4OJY-A nrPDB Length = 687 Score = 30.4 bits (67), Expect = 2.5, Method: Composition-based stats. Identities = 17/105 (16%), Positives = 30/105 (28%), Gaps = 8/105 (7%) Query: 418 PQGAREYFAPLAEATRKLDPTRPITCVN-------VMFCDAHTDTISDLFDVLCLNRYYG 470 +F R+L P PIT + F + DV+ + Y Sbjct: 230 TDQTISFFENEIVPLRELTPHIPITTNFMADTHDLIPFQGLDYSKFAKHLDVISWDAYPA 289 Query: 471 WYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHS 515 W+ + ++ QP ++ E +L H Sbjct: 290 WHNDWESTADLAMKVGFINDLYRSLKQQPFLLME-CTPSLVNWHK 333 >5WI9-A nrPDB Length = 470 Score = 30.4 bits (67), Expect = 2.6, Method: Composition-based stats. Identities = 14/52 (26%), Positives = 23/52 (44%), Gaps = 10/52 (19%) Query: 542 AVVGEQVWNFAD-------FATSQGILRVGGNKKGIFTRDRKPKSAAFLLQK 586 V G W+ D + +G+ V N K ++RKPKS+A ++ Sbjct: 402 RVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSK---QKERKPKSSAHYYKQ 450 >4W8L-A nrPDB Length = 352 Score = 30.4 bits (67), Expect = 2.6, Method: Composition-based stats. Identities = 42/291 (14%), Positives = 80/291 (27%), Gaps = 56/291 (19%) Query: 343 EHGIVVIDET-----AAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIA 397 G V E A N+ + + + N ++ A + + + Sbjct: 55 TEGKFVWSEADKLVNFAAANNMQVRGHTLLWHSQVPDWFFTDPNDPSKPATREQL---MQ 111 Query: 398 RDKNHPSVVM---------WSIANEPDTRPQGAREYFA---------------------P 427 R K H ++ W + NE + G R + Sbjct: 112 RMKTHIQTIVSRYKGKVHTWDVVNEVISDGGGLRNQASGSKWRDIIGDVDGDGDDSDYIE 171 Query: 428 L-AEATRKLDPTRPITCVNVMFCDAHTDTISDLF-------------DVLCLNRYYGWYV 473 L R+ DP + +N + ++D+ D + + Y Sbjct: 172 LAFRYAREADPD-AVLVINDYGIEGSVSKMNDMVKLVEKLLAKGTPIDAIGFQMHVSMY- 229 Query: 474 QSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMY 533 D++ + + + ++ Y ++ M + Y+ L Sbjct: 230 -GPDIKQIREAFNRAAALGVHIQVTELDMSIYSGNSEQEKPVTDEMMLEQAYRYRALFDL 288 Query: 534 HRVFDRVSAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPK-SAAFL 583 + FD + +W AD T V G K DRK K A+ Sbjct: 289 FKEFDDRGVMDSVTLWGLADDGTWLDDFPVKGRKDAPLLFDRKLKAKPAYW 339 >1ECE-A nrPDB Length = 358 Score = 30.1 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 22/116 (18%), Positives = 40/116 (34%), Gaps = 14/116 (12%) Query: 315 HALMDWIGANSYRTSHY---------PYAEEMLDW-ADEHGIV---VIDETAAVGFNLSL 361 + +G N+ R + P + D G+ V+D+ A + L Sbjct: 50 LDQIKSLGYNTIRLPYSDDILKPGTMPNSINFYQMNQDLQGLTSLQVMDKIVAYAGQIGL 109 Query: 362 GIGFEAGNKPKELYSEEAVNGETQQA-HLQAIKELIARDKNHPSVVMWSIANEPDT 416 I + S +A + ++ L R K +P+VV + + NEP Sbjct: 110 RIILDRHRPDCSGQSALWYTSSVSEATWISDLQALAQRYKGNPTVVGFDLHNEPHD 165 >4Y7E-A nrPDB Length = 346 Score = 30.1 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 10/44 (22%), Positives = 14/44 (31%), Gaps = 8/44 (18%) Query: 284 NHKPFYFTGFGRHEDADLRGKGFDNVLMVHDHALMDWIGANSYR 327 N F G H G+ A + +GAN+ R Sbjct: 50 NGNDFVMRGVN-HAHTWYPGQT-------RSLADIKALGANTVR 85 >6GP5-A nrPDB Length = 352 Score = 30.1 bits (66), Expect = 3.0, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 25/50 (50%), Gaps = 3/50 (6%) Query: 460 FDVLCLNRYYGWYVQSGDLETAEKVLEK---ELLAWQEKLHQPIIITEYG 506 +D++ ++ Y W Q G KV + + ++K ++P++I E G Sbjct: 244 YDMIGMSLYPYWAEQEGKTGGWLKVADDCIANIKHVKQKYNKPVMICEIG 293 >6HIZ-Ck nrPDB Length = 874 Score = 30.1 bits (66), Expect = 3.1, Method: Composition-based stats. Identities = 9/49 (18%), Positives = 18/49 (36%), Gaps = 4/49 (8%) Query: 40 QESRAIAVPGSFNDQFADADIRNYAGNVWYQREVFIPKGWAGQRIVLRF 88 + F +Q+ + + Y WYQR + + + + LR Sbjct: 665 PHQFNVPAELGFVEQYDNLQYKRYDWQGWYQRMLDV----HNRNVSLRC 709 >6GPA-A nrPDB Length = 314 Score = 30.1 bits (66), Expect = 3.3, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 25/50 (50%), Gaps = 3/50 (6%) Query: 460 FDVLCLNRYYGWYVQSGDLETAEKVLEK---ELLAWQEKLHQPIIITEYG 506 +D++ ++ Y W Q G KV + + ++K ++P++I E G Sbjct: 208 YDMIGMSLYPYWAEQEGKTGGWLKVADDCIANIKHVKQKYNKPVMICEIG 257 >1BGG-A nrPDB Length = 448 Score = 29.7 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 16/65 (24%), Positives = 24/65 (36%), Gaps = 2/65 (3%) Query: 524 EYQCAWLDMYHRVFDRVSAVVGEQVWNFAD-FATSQG-ILRVGGNKKGIFTRDRKPKSAA 581 Y L HR V G W+ D F ++G +R G T+ R PK + Sbjct: 373 SYMQQHLVQVHRTIHDGLHVKGYMAWSLLDNFEWAEGYNMRFGMIHVDFRTQVRTPKESY 432 Query: 582 FLLQK 586 + + Sbjct: 433 YWYRN 437 >4IPN-B nrPDB Length = 487 Score = 29.7 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 23/119 (19%), Positives = 40/119 (33%), Gaps = 17/119 (14%) Query: 312 VHDHALMDWIGANSYRTS-----HYP------YAEEMLDWADEHGIVVIDETAAVGFNLS 360 D +L +G N +RTS +P E L + DE DE A G Sbjct: 81 KEDISLFSEMGFNVFRTSIAWSRIFPKGDEEEPNEAGLKYYDEL----FDELHAHGIEPL 136 Query: 361 LGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQ 419 + + V+ + + + ++ R K+ V W NE ++ + Sbjct: 137 VTLSHYETPLYLARKYHGWVDRRMIHFYEKFARTVLERYKD--KVKYWLTFNEVNSVLE 193 >3AC0-A nrPDB Length = 845 Score = 29.7 bits (65), Expect = 3.5, Method: Composition-based stats. Identities = 9/31 (29%), Positives = 16/31 (51%) Query: 110 GYTPFEADVTPYVIAGKSVRITVCVNNELNW 140 YT FE D++ + + + I+V V N + Sbjct: 719 SYTTFELDISDFKVTDDKIAISVDVKNTGDK 749 >4LX4-A nrPDB Length = 330 Score = 29.7 bits (65), Expect = 3.5, Method: Composition-based stats. Identities = 15/69 (21%), Positives = 28/69 (40%) Query: 385 QQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQGAREYFAPLAEATRKLDPTRPITCV 444 +A+ ++L R K HP ++ + I NEP + +A R++D I Sbjct: 116 YEAYASVWRKLAERFKGHPGLLGYDIMNEPHSTVGLWPGAAQAAVDAIREVDDQTLIFIE 175 Query: 445 NVMFCDAHT 453 + A+ Sbjct: 176 GERWSSAYH 184 >4C9D-A nrPDB Length = 268 Score = 29.7 bits (65), Expect = 4.3, Method: Composition-based stats. Identities = 11/66 (16%), Positives = 21/66 (31%), Gaps = 12/66 (18%) Query: 229 GTSGTLQVVNPHL--------WQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAV---- 276 G + + +P L WQ + Y A + ++ G R++ Sbjct: 155 GRTRYTPLPDPRLIAGSLLDKWQAHSPFPYNPKEEAALRELFELDLEVAGFRNLRFHRVQ 214 Query: 277 KGEQFL 282 G+ F Sbjct: 215 AGKGFF 220 >2WSI-A nrPDB Length = 306 Score = 29.7 bits (65), Expect = 4.3, Method: Composition-based stats. Identities = 30/151 (19%), Positives = 48/151 (31%), Gaps = 33/151 (21%) Query: 335 EEMLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKE 394 + + ++ D T F L G K S +N HL+ Sbjct: 186 PDFMRL---QPLLHWDLTNIWSFLLYSNEPIC-GLYGKGFTSIGGINNSLPNPHLR---- 237 Query: 395 LIARDKNHPSV-VMWSIANEPDTRPQGAREYFAPLAEATRKLDPTRPITCVNVMFCDAHT 453 +D N+P++ W I + +G R T PI+ V+ + Sbjct: 238 ---KDSNNPALHFEWEIIHAFGKDAEGERSSAIN----------TSPISVVDKERFSKYH 284 Query: 454 DTISDLFDVLCLNRYYGWYVQSGDLETAEKV 484 D N Y GWY+ LE A ++ Sbjct: 285 D-----------NYYPGWYLVDDTLERAGRI 304 >5IDI-A nrPDB Length = 452 Score = 29.7 bits (65), Expect = 4.3, Method: Composition-based stats. Identities = 32/162 (19%), Positives = 52/162 (32%), Gaps = 34/162 (20%) Query: 452 HTDTISDLFDVLCLNRYYG---WY--VQSGDLETAEKVLEKELLAWQEKL---------- 496 + I D + LN Y G Y + E+ L K + W+ Sbjct: 277 DMEEIKQEIDFVGLNYYSGHMVKYDPNSPARVSFVERNLPKTAMGWEIVPEGIYWILKGV 336 Query: 497 ---HQP--IIITEYGV--DTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVVGEQVW 549 + P + IT G D + D +Y A ++ R + G VW Sbjct: 337 KEEYNPQEVYITGNGAAFDDVVSEGGKVHDQNRIDYLRAHIEQVWRAIQDGVPLKGYFVW 396 Query: 550 NFAD-FATSQ------GILRVGGNKKGIFTRDRKPKSAAFLL 584 + D F ++ GI+ V N T+ R K + + Sbjct: 397 SLLDNFEWAEGYSKRFGIVYVDYN-----TQKRIIKDSGYWY 433 >5XGZ-A nrPDB Length = 457 Score = 29.3 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 18/118 (15%), Positives = 28/118 (23%), Gaps = 25/118 (21%) Query: 312 VHDHALMDWIGANSYRTS-------------HYPYAEEML-DWADEHGIVVIDETAAVGF 357 D A+M +G N+YR S + D E + Sbjct: 66 REDIAIMKQLGVNAYRFSIAWPRILPDGRGRVNQAGVDFYERLVDSL-----LEQGIEPY 120 Query: 358 NLSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPD 415 + + + V + + L R V W NEP Sbjct: 121 ATLYHWDMPQVQHDRTPWYDRGVVDAFVEYTDVITRRLSDR------VKYWMTLNEPW 172 >4MDP-A nrPDB Length = 499 Score = 29.3 bits (64), Expect = 4.8, Method: Composition-based stats. Identities = 10/18 (55%), Positives = 12/18 (66%) Query: 312 VHDHALMDWIGANSYRTS 329 D AL+ +GANSYR S Sbjct: 82 KEDIALLKELGANSYRFS 99 >1J10-A nrPDB Length = 516 Score = 29.3 bits (64), Expect = 4.8, Method: Composition-based stats. Identities = 9/37 (24%), Positives = 16/37 (43%), Gaps = 2/37 (5%) Query: 525 YQCAWLDMYHRVFDRVSAVVGEQVWNFAD--FATSQG 559 Y +L+ Y + + + ++GE N D F G Sbjct: 249 YGKDYLEWYQGILENHTKLIGELAHNAFDTTFQVPIG 285 >6ENS-A nrPDB Length = 193 Score = 29.3 bits (64), Expect = 5.1, Method: Composition-based stats. Identities = 17/87 (19%), Positives = 27/87 (31%), Gaps = 18/87 (20%) Query: 166 NYAGIHRSVMLYTTPNTWVD-DITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVV 224 + G+HR V L + D ++++ + D G VE + Sbjct: 119 SGTGLHRYVWLVYEQEQPLSCDEPILSNKSGDNR-----------GKFKVETFRKKYNLG 167 Query: 225 ATGQGTSGTLQVVNPHLWQPGEGYLYE 251 A GT + W LYE Sbjct: 168 APVAGTCYQAE------WDDYVPKLYE 188 >5ECU-A nrPDB Length = 555 Score = 28.9 bits (63), Expect = 5.9, Method: Composition-based stats. Identities = 41/257 (15%), Positives = 77/257 (29%), Gaps = 52/257 (20%) Query: 284 NHKPFYFTGFGRH--EDADLRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWA 341 N +P G H + + +D G N R + Y Sbjct: 42 NGEPIQLRGMSTHGLQWFPQIINNNAFAALANDW------GCNVIRLAMY---------- 85 Query: 342 DEHGIVVIDETAAVGFNLSLGIGFEAGNKPKELYSEEAVNG-----ETQQAHLQAIKELI 396 G V + GI N + +N E + KE+ Sbjct: 86 --IGEGGYATNPQVKDKVIEGIKLAIQNDMYVIVDWHVLNPGDPNAEIYKGAKDFFKEIA 143 Query: 397 ARDKN--HPSVVMWSIANEPDTRP----------QGAREYFAPLAEATRKLDPTRPITCV 444 + N H +++ + NEP+ + + Y P+ + R++ I Sbjct: 144 QKFPNDFH---IIYELCNEPNPTDPGVTNDEAGWKKVKAYAEPIIKMLRQMGNENIIIIG 200 Query: 445 NVMFCD----AHTDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPI 500 + + A D I+D + ++ Y G + G + K+ + P+ Sbjct: 201 SPNWSQRPDFAIKDPIADDKVMYSVHFYTGTHKVDGYVFENMKMAIEA--------GVPV 252 Query: 501 IITEYGVDTLAGLHSMY 517 +TE+G +G Y Sbjct: 253 FVTEWGTSEASGDGGPY 269 >5NS7-A nrPDB Length = 454 Score = 28.9 bits (63), Expect = 6.4, Method: Composition-based stats. Identities = 31/129 (24%), Positives = 46/129 (35%), Gaps = 23/129 (17%) Query: 469 YGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGV---DTLAGLHSMYTDMWSEEY 525 GW V + + + KE + I ITE G D + + S Y Sbjct: 335 MGWEVHAQSFTELLERVSKEYKP------KEIFITENGSAWDDEVVDGKVDDPNRVS--Y 386 Query: 526 QCAWLDMYHRVFDRVSAVVGEQVWNFAD-------FATSQGILRVGGNKKGIFTRDRKPK 578 LD ++ + G W+ D +A GI+ V T+ R PK Sbjct: 387 LERHLDAMFAAKNKGVPISGYFAWSLIDNFEWAYGYAKRFGIIYVDYQ-----TQKRIPK 441 Query: 579 SAAFLLQKR 587 S+A+ QKR Sbjct: 442 SSAYYYQKR 450 >3NCO-A nrPDB Length = 320 Score = 28.9 bits (63), Expect = 7.3, Method: Composition-based stats. Identities = 35/235 (14%), Positives = 72/235 (30%), Gaps = 50/235 (21%) Query: 310 LMVHDHALMDWIGANSYRT-----SH----YPY--AEEMLDWADEHGIVVIDETAAVGFN 358 + ++ G +S R +H YPY + LD + V Sbjct: 42 IEDEYFKIIKERGFDSVRIPIRWSAHISEKYPYEIDKFFLDR--------VKHVVDVALK 93 Query: 359 LSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRP 418 L + + + + + + Q + K++P + + I NEP Sbjct: 94 NDLVVIINCHHFEELYQAPDKYGPVLVEIWKQVAQAF----KDYPDKLFFEIFNEPAQNL 149 Query: 419 QGAR--EYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFD----VLCLNRYY--- 469 + E + + RK +P+R + + + L D ++ + Y Sbjct: 150 TPTKWNELYPKVLGEIRKTNPSRIVIIDVPNWSNYSYVRELKLVDDKNIIVSFHYYEPFN 209 Query: 470 -----------------GWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGV 507 W + ++E K + W +K + PI + E+G Sbjct: 210 FTHQGAEWVSPTLPIGVKWEGKDWEVEQIRNHF-KYVSEWAKKNNVPIFLGEFGA 263 >3W53-A nrPDB Length = 506 Score = 28.9 bits (63), Expect = 7.4, Method: Composition-based stats. Identities = 20/120 (16%), Positives = 35/120 (29%), Gaps = 24/120 (20%) Query: 312 VHDHALMDWIGANSYRTSH------------YPYAEEML-DWADEHGIVVIDETAAVGFN 358 D LM +G +SYR S P + DE E + + Sbjct: 101 REDVQLMRELGLDSYRFSTSWARVVPGGRTVNPEGLDFYSRLVDEL-----LENGILPWL 155 Query: 359 LSLGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRP 418 + + ++ + + + ++L R K H W+ NEP Sbjct: 156 TLYHWDLPQALEERGGWTNRETSYKFLEYAETVHEKLGDRVK-H-----WTTFNEPLCSS 209 >4GBU-A nrPDB Length = 400 Score = 28.5 bits (62), Expect = 9.5, Method: Composition-based stats. Identities = 14/47 (29%), Positives = 23/47 (48%), Gaps = 3/47 (6%) Query: 500 IIITEYGV--DTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRVSAVV 544 +IITE G AG + +WSEE W +++ + ++ S V Sbjct: 68 MIITE-GAFISPQAGGYDNAPGVWSEEQMVEWTKIFNAIHEKKSFVW 113 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.131 0.395 Lambda K H 0.267 0.0401 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 25,753,827 Number of Sequences: 36641 Number of extensions: 1090912 Number of successful extensions: 3613 Number of sequences better than 10.0: 132 Number of HSP's better than 10.0 without gapping: 94 Number of HSP's successfully gapped in prelim test: 92 Number of HSP's that attempted gapping in prelim test: 2976 Number of HSP's gapped (non-prelim): 263 length of query: 603 length of database: 10,336,785 effective HSP length: 103 effective length of query: 500 effective length of database: 6,562,762 effective search space: 3281381000 effective search space used: 3281381000 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 62 (28.5 bits)