BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P05708 (918 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1BG3-A nrPDB 1895 0.0 4FOI-A nrPDB 1778 0.0 5HFU-A nrPDB 1400 0.0 3HM8-A nrPDB 601 e-172 3W0L-A nrPDB 508 e-144 4DCH-A nrPDB 503 e-142 1BDG-A nrPDB 385 e-107 5ZQT-A nrPDB 270 2e-72 3O1W-A nrPDB 267 1e-71 1IG8-A nrPDB 258 8e-69 4QS9-A nrPDB 251 7e-67 3B8A-X nrPDB 246 4e-65 2YHX-A nrPDB 40 0.003 1HKG-A nrPDB 40 0.007 4FDG-B nrPDB 33 0.58 3F9V-A nrPDB 33 0.63 4R7Y-A nrPDB 33 0.74 3Q5R-A nrPDB 32 0.93 >1BG3-A nrPDB Length = 918 Score = 1895 bits (4908), Expect = 0.0, Method: Compositional matrix adjust. Identities = 918/918 (100%), Positives = 918/918 (100%) Query: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTAS 60 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTAS Sbjct: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTAS 60 Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVH 120 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVH Sbjct: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVH 120 Query: 121 GSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGV 180 GSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGV Sbjct: 121 GSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGV 180 Query: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYME 240 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYME Sbjct: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYME 240 Query: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGM 300 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGM Sbjct: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGM 300 Query: 301 YMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLG 360 YMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLG Sbjct: 301 YMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLG 360 Query: 361 VEPSDVDCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMH 420 VEPSDVDCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMH Sbjct: 361 VEPSDVDCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMH 420 Query: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLS 480 PQYSRRFHKTLRRLVPDSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLS Sbjct: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLS 480 Query: 481 KQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRV 540 KQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRV Sbjct: 481 KQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRV 540 Query: 541 LLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGF 600 LLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGF Sbjct: 541 LLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGF 600 Query: 601 TFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVG 660 TFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVG Sbjct: 601 TFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVG 660 Query: 661 TMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDD 720 TMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDD Sbjct: 661 TMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDD 720 Query: 721 IRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRG 780 IRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRG Sbjct: 721 IRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRG 780 Query: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAA 840 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAA Sbjct: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAA 840 Query: 841 VVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKG 900 VVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKG Sbjct: 841 VVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKG 900 Query: 901 AALITAVGVRLRGDPSIA 918 AALITAVGVRLRGDPSIA Sbjct: 901 AALITAVGVRLRGDPSIA 918 >4FOI-A nrPDB Length = 917 Score = 1778 bits (4606), Expect = 0.0, Method: Compositional matrix adjust. Identities = 849/916 (92%), Positives = 892/916 (97%) Query: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTAS 60 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDE LIDI+TRF+KEMKNGLSRD+NPTA+ Sbjct: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 60 Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVH 120 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNV MESE+YDTPENIVH Sbjct: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120 Query: 121 GSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGV 180 GSG+QLFDHVA+CLGDFMEK+KIKDKKLPVGFTFSFPC+QSKIDEA+LITWTKRFKASGV Sbjct: 121 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 180 Query: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYME 240 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQ CEVGLIIGTGTNACYME Sbjct: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 240 Query: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGM 300 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRE+DRGSLNPGKQLFEKMVSGM Sbjct: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 300 Query: 301 YMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLG 360 Y+GELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEK+KEG+ NAKEILTRLG Sbjct: 301 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 360 Query: 361 VEPSDVDCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMH 420 VEPSD DCVSVQH+CTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGV+GSLYK H Sbjct: 361 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVNGSLYKTH 420 Query: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLS 480 PQYSRRFHKTLRRLVPDSDVRFLLSESG+GKGAAMVTAVAYRLAEQHRQIEETLAHF L+ Sbjct: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 480 Query: 481 KQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRV 540 K L+EVKKR+R EME+GLRK+T++ A VKMLPSFVR PDGTE+GDFLALDLGGTNFRV Sbjct: 481 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 540 Query: 541 LLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGF 600 LLVKIRSGKKRTVEMHNKIY+IP+EIMQGTG+ELFDHIVSCISDFLDYMGIKGPRMPLGF Sbjct: 541 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 600 Query: 601 TFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVG 660 TFSFPC QT+LD GILI+WTKGFKATDC GHDV +LLRDA+KRREEFDLDVVAVVNDTVG Sbjct: 601 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 660 Query: 661 TMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDD 720 TMMTCAYEEPTCE+GLIVGTG+NACYMEEMKNVEMVEG+QGQMCINMEWGAFGDNGCLDD Sbjct: 661 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 720 Query: 721 IRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRG 780 IRT +D++VDEYSLN+GKQR+EKMISGMYLGEIVRNILIDFTKKGFLFRGQISE LKTRG Sbjct: 721 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 780 Query: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAA 840 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVS+RAAQLCGAGMAA Sbjct: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 840 Query: 841 VVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKG 900 VV+KIRENRGLD LNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKC VSFLLSEDGSGKG Sbjct: 841 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 900 Query: 901 AALITAVGVRLRGDPS 916 AALITAVGVRLR + S Sbjct: 901 AALITAVGVRLRTEAS 916 >5HFU-A nrPDB Length = 923 Score = 1400 bits (3625), Expect = 0.0, Method: Compositional matrix adjust. Identities = 653/896 (72%), Positives = 778/896 (86%) Query: 17 DQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSE 76 DQV+K+D+YLY MRLSDE L++I RF+KEM+ GL +PTA+VKMLPTFVRS PDG+E Sbjct: 23 DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 82 Query: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGD 136 G+F+ALDLGG++FR+L V+V Q V ME++IY PE+I+ GSGTQLFDH+A+CL + Sbjct: 83 HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN 142 Query: 137 FMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKR 196 FM+K +IKDKKLP+GFTFSFPC Q+K+DE+ L++WTK FK+SGVEG DVV L+ KAI++R Sbjct: 143 FMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRR 202 Query: 197 GDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256 GD+D +IVAVVNDTVGTMMTCGYDD CE+GLI+GTG+NACYMEE+RHID+VEGDEGRMC Sbjct: 203 GDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMC 262 Query: 257 INTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKE 316 IN EWGAFGDDGSL DIRTEFD+E+D GSLNPGKQLFEKM+SGMYMGELVRLILVKMAKE Sbjct: 263 INMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKE 322 Query: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVSVQHICT 376 LLF G+++PELL G+F T D+S IE +K+GI+ A+E+L RLG++P+ DCV+ IC Sbjct: 323 ELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQ 382 Query: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVP 436 IVS RSA+L AATL A+L R+++NKG RLR+T+GVDGS+YK HP +++R HKT+RRLVP Sbjct: 383 IVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVP 442 Query: 437 DSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLSKQTLMEVKKRLRTEME 496 DVRFL SE G+GKGAAMVTAVAYRLA+QHR ++TL H +LS L+EVK+R++ EME Sbjct: 443 GCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEME 502 Query: 497 MGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMH 556 GL KET++ A VKMLP++V + PDGTE GDFLALDLGGTNFRVLLV++R+GK VEMH Sbjct: 503 RGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMH 562 Query: 557 NKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQTNLDCGIL 616 NKIY+IP E+M GTGDELFDHIV CI+DFL+YMG+KG +PLGFTFSFPC Q +LD IL Sbjct: 563 NKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESIL 622 Query: 617 ISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGL 676 + WTKGFKA+ CEG DV +LL++A+ RREEFDLDVVAVVNDTVGTMMTC +E+P CE+GL Sbjct: 623 LKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGL 682 Query: 677 IVGTGTNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNS 736 IVGTG+NACYMEEM+NVE+VEG +G+MC+NMEWGAFGDNGCLDD RT+FD VDE SLN Sbjct: 683 IVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNP 742 Query: 737 GKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLA 796 GKQRFEKMISGMYLGEIVRNILIDFTK+G LFRG+ISE LKTRGIFETKFLSQIESD LA Sbjct: 743 GKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLA 802 Query: 797 LLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLNV 856 LLQVRAILQ LGL STCDDSI+VK VC VV++RAAQLCGAGMAAVV++IRENRGLD L V Sbjct: 803 LLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKV 862 Query: 857 TVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKGAALITAVGVRLR 912 TVGVDGTLYKLHPHF+++MH+TVK+L+PKC VSFL SEDGSGKGAALITAV R+R Sbjct: 863 TVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIR 918 Score = 564 bits (1453), Expect = e-161, Method: Compositional matrix adjust. Identities = 260/451 (57%), Positives = 351/451 (77%) Query: 461 YRLAEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIP 520 ++ ++Q +++++ L H RLS +TL+E+ KR R EME GL T+ A VKMLP+FVRS P Sbjct: 19 FQGSDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTP 78 Query: 521 DGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVS 580 DGTEHG+FLALDLGGTNFRVL VK+ + VEM N+IY+IP +IM+G+G +LFDHI Sbjct: 79 DGTEHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAE 138 Query: 581 CISDFLDYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDA 640 C+++F+D + IK ++PLGFTFSFPCHQT LD L+SWTKGFK++ EG DV +L+R A Sbjct: 139 CLANFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKA 198 Query: 641 VKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQ 700 ++RR +FD+D+VAVVNDTVGTMMTC Y++ CEIGLIVGTG+NACYMEEM++++MVEG++ Sbjct: 199 IQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDE 258 Query: 701 GQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILID 760 G+MCINMEWGAFGD+G L+DIRT+FD+ +D SLN GKQ FEKMISGMY+GE+VR IL+ Sbjct: 259 GRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVK 318 Query: 761 FTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVK 820 K+ LF G++S L G FETK +S IE ++ + + R +L +LGL+ T +D + Sbjct: 319 MAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATH 378 Query: 821 TVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVK 880 +C +VS R+A LC A +AAV+++I+EN+G + L T+GVDG++YK HPHF++ +H+TV+ Sbjct: 379 RICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVR 438 Query: 881 ELSPKCTVSFLLSEDGSGKGAALITAVGVRL 911 L P C V FL SEDGSGKGAA++TAV RL Sbjct: 439 RLVPGCDVRFLRSEDGSGKGAAMVTAVAYRL 469 Score = 524 bits (1349), Expect = e-149, Method: Compositional matrix adjust. Identities = 243/449 (54%), Positives = 337/449 (75%) Query: 17 DQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSE 76 DQ + K L ++LS + L+++ R K EM+ GLS++ + +A VKMLPT+V + PDG+E Sbjct: 471 DQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTE 530 Query: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGD 136 KGDF+ALDLGG++FR+L V+V + K V M ++IY P+ ++HG+G +LFDH+ C+ D Sbjct: 531 KGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIAD 590 Query: 137 FMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKR 196 F+E +K LP+GFTFSFPC+Q+ +DE++L+ WTK FKASG EG DVV LL +AI +R Sbjct: 591 FLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRR 650 Query: 197 GDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256 ++D ++VAVVNDTVGTMMTCG++D CEVGLI+GTG+NACYMEE+R+++LVEG+EGRMC Sbjct: 651 EEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMC 710 Query: 257 INTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKE 316 +N EWGAFGD+G L+D RTEFD +D SLNPGKQ FEKM+SGMY+GE+VR IL+ K Sbjct: 711 VNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKR 770 Query: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVSVQHICT 376 GLLF GRI+ L TRG F T +S IE D + + IL LG+E + D + V+ +CT Sbjct: 771 GLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCT 830 Query: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVP 436 +V+ R+A L A + A+++R+R+N+G L+ TVGVDG+LYK+HP +++ H+T++ L P Sbjct: 831 VVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAP 890 Query: 437 DSDVRFLLSESGTGKGAAMVTAVAYRLAE 465 DV FL SE G+GKGAA++TAVA R+ E Sbjct: 891 KCDVSFLQSEDGSGKGAALITAVACRIRE 919 >3HM8-A nrPDB Length = 445 Score = 601 bits (1550), Expect = e-172, Method: Compositional matrix adjust. Identities = 290/445 (65%), Positives = 353/445 (79%), Gaps = 7/445 (1%) Query: 467 HRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHG 526 R +EETLA FRL+ L V+ ++R M GLR E +S ++MLP+FVR+ PDG+E G Sbjct: 3 RRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASS---LRMLPTFVRATPDGSERG 59 Query: 527 DFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFL 586 DFLALDLGGTNFRVLLV++ +G V++ ++IYSIP + QG+G +LFDHIV CI DF Sbjct: 60 DFLALDLGGTNFRVLLVRVTTG----VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQ 115 Query: 587 DYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREE 646 G+ G +PLGFTFSFPC Q LD GIL++WTKGFKA+DCEG DV SLLR+A+ RR+ Sbjct: 116 QKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQA 175 Query: 647 FDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMCIN 706 +L+VVA+VNDTVGTMM+C YE+P CEIGLIVGTGTNACYMEE++NV V G+ G+MCIN Sbjct: 176 VELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCIN 235 Query: 707 MEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGF 766 MEWGAFGD+G L + T FD VD+ S+N GKQRFEKMISGMYLGEIVR+IL+ T G Sbjct: 236 MEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGV 295 Query: 767 LFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVV 826 LFRGQ + L+TR IF+TKFLS+IESD LAL QVRAIL+ LGL T DD+++V VC V Sbjct: 296 LFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAV 355 Query: 827 SKRAAQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKC 886 S+RAAQLCGAG+AAVVEKIRENRGL+ L V+VGVDGTLYKLHP FS ++ TV+EL+P+C Sbjct: 356 SQRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRC 415 Query: 887 TVSFLLSEDGSGKGAALITAVGVRL 911 V+FL SEDGSGKGAAL+TAV RL Sbjct: 416 VVTFLQSEDGSGKGAALVTAVACRL 440 Score = 478 bits (1229), Expect = e-135, Method: Compositional matrix adjust. Identities = 230/449 (51%), Positives = 311/449 (69%), Gaps = 7/449 (1%) Query: 20 KKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGD 79 + +++ L RL+ + L + + +K M GL + +S++MLPTFVR+ PDGSE+GD Sbjct: 4 RLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGE---ASSLRMLPTFVRATPDGSERGD 60 Query: 80 FIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFME 139 F+ALDLGG++FR+L V+V V + SEIY PE + GSG QLFDH+ DC+ DF + Sbjct: 61 FLALDLGGTNFRVLLVRVT----TGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQ 116 Query: 140 KKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDY 199 K+ + + LP+GFTFSFPCRQ +D+ +L+ WTK FKAS EG DVV LL +AI +R Sbjct: 117 KQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAV 176 Query: 200 DANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 259 + N+VA+VNDTVGTMM+CGY+D +CE+GLI+GTGTNACYMEELR++ V GD GRMCIN Sbjct: 177 ELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINM 236 Query: 260 EWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLL 319 EWGAFGDDGSL + T FD +D+ S+NPGKQ FEKM+SGMY+GE+VR IL+ + G+L Sbjct: 237 EWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVL 296 Query: 320 FEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVSVQHICTIVS 379 F G+ L TR F T +S IE D ++ + IL LG+ + D + V +C VS Sbjct: 297 FRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVS 356 Query: 380 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDSD 439 R+A L A + A++ ++R+N+G L +VGVDG+LYK+HP++S T+R L P Sbjct: 357 QRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCV 416 Query: 440 VRFLLSESGTGKGAAMVTAVAYRLAEQHR 468 V FL SE G+GKGAA+VTAVA RLA+ R Sbjct: 417 VTFLQSEDGSGKGAALVTAVACRLAQLTR 445 >3W0L-A nrPDB Length = 458 Score = 508 bits (1307), Expect = e-144, Method: Compositional matrix adjust. Identities = 241/447 (53%), Positives = 329/447 (73%), Gaps = 2/447 (0%) Query: 467 HRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHG 526 ++++ L+ F L ++ L + R++ EME GL ETN +A+VKMLP++VRS PDG+E G Sbjct: 6 QNEVDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSEVG 65 Query: 527 DFLALDLGGTNFRVLLVKIRSG--KKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISD 584 DFLALDLGGTNFRV+LVK+ + VE +K+YSIP++ M GT + LFD+I CISD Sbjct: 66 DFLALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPVDAMTGTAEMLFDYIAECISD 125 Query: 585 FLDYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRR 644 +LD +K ++PLGFTFSFP ++D GIL++WTKGFKA+ EG++V LLRDA+KRR Sbjct: 126 YLDQQNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRR 185 Query: 645 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMC 704 +F++DVVA+VNDTV TM++C YE+ CE+GLIVGTG NACYMEEM NVE+VEG +G+MC Sbjct: 186 GDFEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGEEGRMC 245 Query: 705 INMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKK 764 +N EWGAFGD G L+D R ++D+VVDE SLN G+Q +EKMI G Y+GE+VR +LI + Sbjct: 246 VNTEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLIKMVNE 305 Query: 765 GFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 824 LF G+ SE LKTRG FET+F+SQIE+D Q IL+ LG+ +T D V+ C Sbjct: 306 NLLFGGESSEKLKTRGAFETQFVSQIEADTSDFKQTLNILRTLGVQATIGDCHAVRLACE 365 Query: 825 VVSKRAAQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 884 VS RAA +C AG+A ++ ++R++R + L +TVGVDG++YKLHP F H TV +L+ Sbjct: 366 SVSTRAAIMCSAGLAGILNRMRQSRREELLRITVGVDGSVYKLHPSFKDKFHATVLKLTS 425 Query: 885 KCTVSFLLSEDGSGKGAALITAVGVRL 911 C ++F+ SE+GSG+GAALI+AV ++ Sbjct: 426 GCEITFIQSEEGSGRGAALISAVAYKM 452 Score = 491 bits (1265), Expect = e-139, Method: Compositional matrix adjust. Identities = 230/446 (51%), Positives = 319/446 (71%), Gaps = 2/446 (0%) Query: 21 KIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDF 80 ++D+ L L +E L ++ R + EM+ GL + N ASVKMLPT+VRS PDGSE GDF Sbjct: 8 EVDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSEVGDF 67 Query: 81 IALDLGGSSFRILRVQVNH--EKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFM 138 +ALDLGG++FR++ V+V E V + ++Y P + + G+ LFD++A+C+ D++ Sbjct: 68 LALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPVDAMTGTAEMLFDYIAECISDYL 127 Query: 139 EKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGD 198 +++ +K KKLP+GFTFSFP R ID+ +L+ WTK FKASG EG +VV LL AIK+RGD Sbjct: 128 DQQNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGD 187 Query: 199 YDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCIN 258 ++ ++VA+VNDTV TM++C Y+D CEVGLI+GTG NACYMEE+ +++LVEG+EGRMC+N Sbjct: 188 FEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGEEGRMCVN 247 Query: 259 TEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGL 318 TEWGAFGD G LED R E+DR +D SLNPG+QL+EKM+ G YMGELVRL+L+KM E L Sbjct: 248 TEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLIKMVNENL 307 Query: 319 LFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVSVQHICTIV 378 LF G + +L TRG F T VS IE D + IL LGV+ + DC +V+ C V Sbjct: 308 LFGGESSEKLKTRGAFETQFVSQIEADTSDFKQTLNILRTLGVQATIGDCHAVRLACESV 367 Query: 379 SFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDS 438 S R+A + +A L ILNR+R ++ LR TVGVDGS+YK+HP + +FH T+ +L Sbjct: 368 STRAAIMCSAGLAGILNRMRQSRREELLRITVGVDGSVYKLHPSFKDKFHATVLKLTSGC 427 Query: 439 DVRFLLSESGTGKGAAMVTAVAYRLA 464 ++ F+ SE G+G+GAA+++AVAY++A Sbjct: 428 EITFIQSEEGSGRGAALISAVAYKMA 453 >4DCH-A nrPDB Length = 473 Score = 503 bits (1294), Expect = e-142, Method: Compositional matrix adjust. Identities = 236/449 (52%), Positives = 338/449 (75%), Gaps = 2/449 (0%) Query: 464 AEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGT 523 A + ++E+ LA F+L ++ L +V +R++ EM+ GLR ET+ +A+VKMLP++VRS P+G+ Sbjct: 10 AAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGS 69 Query: 524 EHGDFLALDLGGTNFRVLLVKIRSGK--KRTVEMHNKIYSIPLEIMQGTGDELFDHIVSC 581 E GDFL+LDLGGTNFRV+LVK+ G+ + +V+ +++YSIP + M GT + LFD+I C Sbjct: 70 EVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISEC 129 Query: 582 ISDFLDYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAV 641 ISDFLD +K ++PLGFTFSFP ++D GIL++WTKGFKA+ EG++V LLRDA+ Sbjct: 130 ISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189 Query: 642 KRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQG 701 KRR +F++DVVA+VNDTV TM++C YE+ CE+G+IVGTG NACYMEEM+NVE+VEG++G Sbjct: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEG 249 Query: 702 QMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDF 761 +MC+N EWGAFGD+G LD+ ++D++VDE S N G+Q +EK+I G Y+GE+VR +L+ Sbjct: 250 RMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRL 309 Query: 762 TKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKT 821 + LF G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V+ Sbjct: 310 VDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRR 369 Query: 822 VCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKE 881 C VS RAA +C AG+A V+ ++RE+R D + +TVGVDG++YKLHP F H +V+ Sbjct: 370 ACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRR 429 Query: 882 LSPKCTVSFLLSEDGSGKGAALITAVGVR 910 L+P C ++F+ SE+GSG+GAAL++AV + Sbjct: 430 LTPSCEITFIESEEGSGRGAALVSAVACK 458 Score = 477 bits (1227), Expect = e-134, Method: Compositional matrix adjust. Identities = 226/454 (49%), Positives = 328/454 (72%), Gaps = 2/454 (0%) Query: 20 KKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGD 79 +K+++ L +L +E L ++ R +KEM GL + + ASVKMLPT+VRS P+GSE GD Sbjct: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73 Query: 80 FIALDLGGSSFRILRVQVNH--EKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDF 137 F++LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD++++C+ DF Sbjct: 74 FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 133 Query: 138 MEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRG 197 ++K ++K KKLP+GFTFSFP R ID+ +L+ WTK FKASG EG +VV LL AIK+RG Sbjct: 134 LDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 193 Query: 198 DYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCI 257 D++ ++VA+VNDTV TM++C Y+D QCEVG+I+GTG NACYMEE+++++LVEGDEGRMC+ Sbjct: 194 DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCV 253 Query: 258 NTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEG 317 NTEWGAFGD G L++ E+DR +D S NPG+QL+EK++ G YMGELVRL+L+++ E Sbjct: 254 NTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDEN 313 Query: 318 LLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVSVQHICTI 377 LLF G + +L TRG F T VS +E D + IL+ LG+ PS DC V+ C Sbjct: 314 LLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACES 373 Query: 378 VSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPD 437 VS R+A++ +A L ++NR+R+++ +R TVGVDGS+YK+HP + RFH ++RRL P Sbjct: 374 VSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPS 433 Query: 438 SDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIE 471 ++ F+ SE G+G+GAA+V+AVA + A Q+E Sbjct: 434 CEITFIESEEGSGRGAALVSAVACKKACMLGQLE 467 >1BDG-A nrPDB Length = 451 Score = 385 bits (989), Expect = e-107, Method: Compositional matrix adjust. Identities = 212/447 (47%), Positives = 284/447 (63%), Gaps = 13/447 (2%) Query: 469 QIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDF 528 ++ E L F LS E+ R+ M +GL+K TN K+++KM PS+V P+GTE G+F Sbjct: 11 KVVEILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTETGNF 70 Query: 529 LALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDY 588 LALDLGGTN+RVL V + GK ++ + + Y IP E M G+G ELF +I ++DFL+ Sbjct: 71 LALDLGGTNYRVLSVTLE-GKGKSPRIQERTYCIPAEKMSGSGTELFKYIAETLADFLEN 129 Query: 589 MGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFD 648 G+K + LGFTFSFPC Q L L+ WTKGF A EGH+VA LL+ + +RE + Sbjct: 130 NGMKDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTELDKRE-LN 188 Query: 649 LDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEG-NQGQMCINM 707 + VAVVNDTVGT+ +CA E+P C +GLIVGTGTN Y+E+ VE+++G + ++ IN Sbjct: 189 VKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGVKEPEVVINT 248 Query: 708 EWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFL 767 EWGAFG+ G LD RT FDK +D SL+ GKQ +EKM+SGMYLGE+VR+I++ ++ L Sbjct: 249 EWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYLVEQKIL 308 Query: 768 FRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSI---LVKTVCG 824 FRG + E LK R T++L+ +E D LL + L+ + I +V+ C Sbjct: 309 FRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEPIDNRIVRYACE 368 Query: 825 VVSKRAAQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 884 +V KRAA L GAG+A ++ +I NR VTVGVDG+LYK HP F M V +L P Sbjct: 369 MVVKRAAYLAGAGIACILRRI--NRS----EVTVGVDGSLYKFHPKFCERMTDMVDKLKP 422 Query: 885 KCTVSFL-LSEDGSGKGAALITAVGVR 910 K T L LSEDGSGKGAA I A R Sbjct: 423 KNTRFCLRLSEDGSGKGAAAIAASCTR 449 Score = 343 bits (879), Expect = 2e-94, Method: Compositional matrix adjust. Identities = 187/433 (43%), Positives = 269/433 (62%), Gaps = 19/433 (4%) Query: 38 DILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQV 97 +I R + M+ GL + N +S+KM P++V P+G+E G+F+ALDLGG+++R+L V + Sbjct: 28 EICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTETGNFLALDLGGTNYRVLSVTL 87 Query: 98 NHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFP 157 K ++ ++ Y P + GSGT+LF ++A+ L DF+E +KDKK +GFTFSFP Sbjct: 88 EG-KGKSPRIQERTYCIPAEKMSGSGTELFKYIAETLADFLENNGMKDKKFDLGFTFSFP 146 Query: 158 CRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTC 217 C Q + A L+ WTK F A GVEG +V +LL + KR + + VAVVNDTVGT+ +C Sbjct: 147 CVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTELDKR-ELNVKCVAVVNDTVGTLASC 205 Query: 218 GYDDQQCEVGLIIGTGTNACYMEELRHIDLVEG-DEGRMCINTEWGAFGDDGSLEDIRTE 276 +D +C VGLI+GTGTN Y+E+ ++L++G E + INTEWGAFG+ G L+ RT+ Sbjct: 206 ALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGVKEPEVVINTEWGAFGEKGELDCWRTQ 265 Query: 277 FDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNT 336 FD+ +D SL+PGKQL+EKMVSGMY+GELVR I+V + ++ +LF G + L R T Sbjct: 266 FDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYLVEQKILFRGDLPERLKVRNSLLT 325 Query: 337 SDVSAIEKDKEG-IQNAKEILTR----LGVEPSDVDCVSVQHICTIVSFRSANLVAATLG 391 ++ +E+D + N +LT VEP +D V++ C +V R+A L A + Sbjct: 326 RYLTDVERDPAHLLYNTHYMLTDDLHVPVVEP--IDNRIVRYACEMVVKRAAYLAGAGIA 383 Query: 392 AILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDSDVRFL--LSESGT 449 IL R+ R TVGVDGSLYK HP++ R + +L P + RF LSE G+ Sbjct: 384 CILRRIN------RSEVTVGVDGSLYKFHPKFCERMTDMVDKLKP-KNTRFCLRLSEDGS 436 Query: 450 GKGAAMVTAVAYR 462 GKGAA + A R Sbjct: 437 GKGAAAIAASCTR 449 >5ZQT-A nrPDB Length = 473 Score = 270 bits (690), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 173/455 (38%), Positives = 246/455 (54%), Gaps = 24/455 (5%) Query: 470 IEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFL 529 IEE F L + + EME GLR + + A +KML S+V ++P G EHG F Sbjct: 16 IEEVEQRFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISYVDNLPTGDEHGLFY 73 Query: 530 ALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFL--- 586 ALDLGGTNFRV+ V++ +KR V + +IP +M GT ELFD I + + F+ Sbjct: 74 ALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTE 133 Query: 587 --DYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRR 644 D+ +G + LGFTFSFP HQT++ G LI WTKGF G DV + L A++ R Sbjct: 134 GEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME-R 192 Query: 645 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEG---NQG 701 + D+ V A+VNDTVGT+ Y + +I+GTGTNA Y+E + G G Sbjct: 193 QGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSG 252 Query: 702 QMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDF 761 M INMEWG F R+D+D +D SLN G+Q +EKMISGMYLGEIVR IL+ Sbjct: 253 NMVINMEWGNFKSERL---PRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKL 309 Query: 762 TKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLA-LLQVRAILQQ-LGL-NSTCDDSIL 818 LF + L+ R I T +S + D L + A L+ LG+ +++ + + Sbjct: 310 AHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYI 369 Query: 819 VKTVCGVVSKRAAQLCGAGMAAVVEKIRENR----GLDHLNVTVGVDGTLYKLHPHFSRI 874 VC +V++R A+L AG+ +++K+ +R G + +DG LY+ + F Sbjct: 370 TLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTC 429 Query: 875 MHQTVKEL---SPKCTVSFLLSEDGSGKGAALITA 906 + T+ +L +V L+ DGSG GAAL+ A Sbjct: 430 LEATLADLLGEEAASSVVVKLANDGSGIGAALLAA 464 Score = 261 bits (667), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 165/435 (37%), Positives = 248/435 (57%), Gaps = 30/435 (6%) Query: 45 KEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN 104 +EM+ GL D P A +KML ++V ++P G E G F ALDLGG++FR++RVQ+ + + Sbjct: 39 EEMERGLRAD--PHAPLKMLISYVDNLPTGDEHGLFYALDLGGTNFRVIRVQLGGREKRV 96 Query: 105 VSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLP------VGFTFSFPC 158 VS + E P +++ G+ +LFD +A L F+ K + +D LP +GFTFSFP Sbjct: 97 VSQQYEEVAIPPHLMVGTSMELFDFIAAELESFV-KTEGEDFHLPEGRQRELGFTFSFPV 155 Query: 159 RQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCG 218 Q+ I LI WTK F +G G DVV L++A++++G D + A+VNDTVGT+ Sbjct: 156 HQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMERQG-LDMKVTALVNDTVGTLAGGR 214 Query: 219 YDDQQCEVGLIIGTGTNACYMEELRHIDLVEG---DEGRMCINTEWGAFGDDGSLEDIRT 275 Y D +I+GTGTNA Y+E I G G M IN EWG F + R+ Sbjct: 215 YVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSGNMVINMEWGNFKSE---RLPRS 271 Query: 276 EFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFN 335 ++D LD SLNPG+Q++EKM+SGMY+GE+VR IL+K+A + LF + +L R Sbjct: 272 DYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKLAHDASLFGDVVPTKLEQRFILR 331 Query: 336 TSDVSAIEKDKEGIQNAKEILTR----LGVEPSDVDCVSVQ-HICTIVSFRSANLVAATL 390 T D+SA+ D + K + + LGV + ++ + H+C +V+ R A L AA + Sbjct: 332 TPDMSAMHHDTS--HDLKHLGAKLKDILGVADTSLEARYITLHVCDLVAERGARLAAAGI 389 Query: 391 GAILNRL-RD---NKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPD---SDVRFL 443 IL +L RD + G+ + RT + +DG LY+ + ++ TL L+ + S V Sbjct: 390 YGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTCLEATLADLLGEEAASSVVVK 449 Query: 444 LSESGTGKGAAMVTA 458 L+ G+G GAA++ A Sbjct: 450 LANDGSGIGAALLAA 464 >3O1W-A nrPDB Length = 485 Score = 267 bits (683), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 163/479 (34%), Positives = 258/479 (53%), Gaps = 33/479 (6%) Query: 448 GTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKA 507 G K A ++A A QI F +S + + + K +E++ GL K+ + Sbjct: 5 GPKKPPARKGSMADVPANLMEQIHGLETLFTVSSEKMRSIVKHFISELDKGLSKKGGN-- 62 Query: 508 TVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIM 567 + M+P +V P G E GDFLALDLGGTN RV+LVK+ G + Y +P + Sbjct: 63 -IPMIPGWVVEYPTGKETGDFLALDLGGTNLRVVLVKL--GGNHDFDTTQNKYRLPDHLR 119 Query: 568 QGTGDELFDHIVSCISDFLDYM---GIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFK 624 GT ++L+ I C+ +F+D G+ P +PLGFTFS+P Q ++ G+L WTKGF Sbjct: 120 TGTSEQLWSFIAKCLKEFVDEWYPDGVSEP-LPLGFTFSYPASQKKINSGVLQRWTKGFD 178 Query: 625 ATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNA 684 EGHDV +L++ +++ ++VVA++NDT GT++ Y +P ++G+I+GTG N Sbjct: 179 IEGVEGHDVVPMLQEQIEKLN-IPINVVALINDTTGTLVASLYTDPQTKMGIIIGTGVNG 237 Query: 685 CYMEEMKNVEMVEG-------NQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSG 737 Y + + +E +EG M IN E+G+F DN L RT +D ++DE S G Sbjct: 238 AYYDVVSGIEKLEGLLPEDIGPDSPMAINCEYGSF-DNEHLVLPRTKYDVIIDEESPRPG 296 Query: 738 KQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLAL 797 +Q FEKM SG YLGEI+R +L+D GF+F+ Q LK + +T + S+IE D Sbjct: 297 QQAFEKMTSGYYLGEIMRLVLLDLYDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFEN 356 Query: 798 LQVRAILQQLGLN--STCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLN 855 L+ L + LN +T + L++ + +V RAA+L G++A+ +K RG + Sbjct: 357 LEDTDDLFKTNLNIETTVVERKLIRKLAELVGTRAARLTVCGVSAICDK----RG--YKT 410 Query: 856 VTVGVDGTLYKLHPHFSRIMHQTVKELS-------PKCTVSFLLSEDGSGKGAALITAV 907 + DG+++ +P + Q +K++ + + +EDGSG GAA+I + Sbjct: 411 AHIAADGSVFNRYPGYKEKAAQALKDIYNWDVEKMEDHPIQLVAAEDGSGVGAAIIACL 469 Score = 237 bits (605), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 150/453 (33%), Positives = 249/453 (54%), Gaps = 32/453 (7%) Query: 31 LSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSF 90 +S E + I+ F E+ GLS+ ++ M+P +V P G E GDF+ALDLGG++ Sbjct: 36 VSSEKMRSIVKHFISELDKGLSKK---GGNIPMIPGWVVEYPTGKETGDFLALDLGGTNL 92 Query: 91 RILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIK--DKKL 148 R++ V++ N + Y P+++ G+ QL+ +A CL +F+++ + L Sbjct: 93 RVVLVKLG--GNHDFDTTQNKYRLPDHLRTGTSEQLWSFIAKCLKEFVDEWYPDGVSEPL 150 Query: 149 PVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVN 208 P+GFTFS+P Q KI+ VL WTK F GVEG DVV +L + I+K + N+VA++N Sbjct: 151 PLGFTFSYPASQKKINSGVLQRWTKGFDIEGVEGHDVVPMLQEQIEKL-NIPINVVALIN 209 Query: 209 DTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVE-------GDEGRMCINTEW 261 DT GT++ Y D Q ++G+IIGTG N Y + + I+ +E G + M IN E+ Sbjct: 210 DTTGTLVASLYTDPQTKMGIIIGTGVNGAYYDVVSGIEKLEGLLPEDIGPDSPMAINCEY 269 Query: 262 GAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFE 321 G+F D+ L RT++D +D S PG+Q FEKM SG Y+GE++RL+L+ + G +F+ Sbjct: 270 GSF-DNEHLVLPRTKYDVIIDEESPRPGQQAFEKMTSGYYLGEIMRLVLLDLYDSGFIFK 328 Query: 322 GRITPELLTRGKFNTSDVSAIEKDK-EGIQNAKEIL-TRLGVEPSDVDCVSVQHICTIVS 379 + +L +TS S IE D E +++ ++ T L +E + V+ ++ + +V Sbjct: 329 DQDISKLKEAYVMDTSYPSKIEDDPFENLEDTDDLFKTNLNIETTVVERKLIRKLAELVG 388 Query: 380 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRL----- 434 R+A L + AI ++ R K + DGS++ +P Y + + L+ + Sbjct: 389 TRAARLTVCGVSAICDK-RGYK-----TAHIAADGSVFNRYPGYKEKAAQALKDIYNWDV 442 Query: 435 --VPDSDVRFLLSESGTGKGAAMVTAVAY-RLA 464 + D ++ + +E G+G GAA++ + RLA Sbjct: 443 EKMEDHPIQLVAAEDGSGVGAAIIACLTQKRLA 475 >1IG8-A nrPDB Length = 486 Score = 258 bits (659), Expect = 8e-69, Method: Compositional matrix adjust. Identities = 161/449 (35%), Positives = 244/449 (54%), Gaps = 29/449 (6%) Query: 448 GTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKA 507 G K A ++A E +QIE F + +TL V K +E+E GL K+ + Sbjct: 5 GPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGN-- 62 Query: 508 TVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIM 567 + M+P +V P G E GDFLA+DLGGTN RV+LVK+ G RT + Y +P + M Sbjct: 63 -IPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKL--GGDRTFDTTQSKYRLP-DAM 118 Query: 568 QGT--GDELFDHIVSCISDFLD---YMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKG 622 + T DEL++ I + F+D GI P +PLGFTFSFP Q ++ GIL WTKG Sbjct: 119 RTTQNPDELWEFIADSLKAFIDEQFPQGISEP-IPLGFTFSFPASQNKINEGILQRWTKG 177 Query: 623 FKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGT 682 F + E HDV +L+ + +R ++VVA++NDT GT++ Y +P ++G+I GTG Sbjct: 178 FDIPNIENHDVVPMLQKQITKRN-IPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGV 236 Query: 683 NACYMEEMKNVEMVEGN-------QGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLN 735 N Y + ++E ++G M IN E+G+F DN + RT +D +DE S Sbjct: 237 NGAYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPR 295 Query: 736 SGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRL 795 G+Q FEKM SG YLGEI+R L+D K+GF+F+ Q + +T + ++IE D Sbjct: 296 PGQQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPF 355 Query: 796 ALLQVRAILQQ--LGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDH 853 L+ L Q G+N+T + L++ + ++ RAA+L G+AA+ +K RG + Sbjct: 356 ENLEDTDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQK----RG--Y 409 Query: 854 LNVTVGVDGTLYKLHPHFSRIMHQTVKEL 882 + DG++Y +P F +K++ Sbjct: 410 KTGHIAADGSVYNRYPGFKEKAANALKDI 438 Score = 204 bits (520), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 125/428 (29%), Positives = 228/428 (53%), Gaps = 25/428 (5%) Query: 19 VKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKG 78 +++I+ + + E L + F E++ GLS+ ++ M+P +V P G E G Sbjct: 24 MQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKK---GGNIPMIPGWVMDFPTGKESG 80 Query: 79 DFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENI-VHGSGTQLFDHVADCLGDF 137 DF+A+DLGG++ R++ V++ ++ + + Y P+ + + +L++ +AD L F Sbjct: 81 DFLAIDLGGTNLRVVLVKLGGDRTFDTTQSK--YRLPDAMRTTQNPDELWEFIADSLKAF 138 Query: 138 MEKKKIK--DKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKK 195 ++++ + + +P+GFTFSFP Q+KI+E +L WTK F +E DVV +L K I K Sbjct: 139 IDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITK 198 Query: 196 RGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEG----- 250 R + +VA++NDT GT++ Y D + ++G+I GTG N Y + I+ ++G Sbjct: 199 R-NIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDD 257 Query: 251 --DEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRL 308 M IN E+G+F D+ + RT++D +D S PG+Q FEKM SG Y+GE++RL Sbjct: 258 IPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRL 316 Query: 309 ILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDK-EGIQNAKEIL-TRLGVEPSDV 366 L+ M K+G +F+ + + +TS + IE+D E +++ ++ G+ + Sbjct: 317 ALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTVQ 376 Query: 367 DCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRR 426 + ++ + ++ R+A L + AI + G + DGS+Y +P + + Sbjct: 377 ERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTG------HIAADGSVYNRYPGFKEK 430 Query: 427 FHKTLRRL 434 L+ + Sbjct: 431 AANALKDI 438 >4QS9-A nrPDB Length = 474 Score = 251 bits (642), Expect = 7e-67, Method: Compositional matrix adjust. Identities = 158/441 (35%), Positives = 237/441 (53%), Gaps = 26/441 (5%) Query: 484 LMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLV 543 L +V + EM GL + SK +KML S+V ++P G E G F ALDLGGTNFRV+ V Sbjct: 33 LRQVADAMTVEMHAGLASDGGSK--LKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRV 90 Query: 544 KIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFL-----DYMGIKGPRMPL 598 + ++R V+ + SIP +M G DELF+ I ++ F+ D+ +G + L Sbjct: 91 LLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQREL 150 Query: 599 GFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDT 658 GFTF+FP QT+L G LI WTKGF + G DV L A++R D+ + A+VNDT Sbjct: 151 GFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERV-GLDMRIAALVNDT 209 Query: 659 VGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEG---NQGQMCINMEWGAFGDN 715 VGT+ Y P +I+GTGTNA Y+E + G G+M INMEWG F + Sbjct: 210 VGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNFRSS 269 Query: 716 GCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEP 775 T+FD +D SLN G+Q EK+ISGMYLGEI+R +L+ + F + Sbjct: 270 HL---PLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSK 326 Query: 776 LKTRGIFETKFLSQIESD-----RLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRA 830 L+ I T +S + +D ++ +++ IL+ ++ +V ++C +++ R Sbjct: 327 LRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEV--PTTSLKMRKVVISLCNIIATRG 384 Query: 831 AQLCGAGMAAVVEKIRENRGLDH--LNVTVGVDGTLYKLHPHFSRIMHQTVKEL---SPK 885 A+L AG+ +++K+ + D + +DG L++ + FS M ++KEL Sbjct: 385 ARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEAS 444 Query: 886 CTVSFLLSEDGSGKGAALITA 906 +V S DGSG GAAL+ A Sbjct: 445 GSVEVTHSNDGSGIGAALLAA 465 Score = 233 bits (594), Expect = 3e-61, Method: Compositional matrix adjust. Identities = 156/436 (35%), Positives = 232/436 (53%), Gaps = 36/436 (8%) Query: 46 EMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNV 105 EM GL+ D + +KML ++V ++P G EKG F ALDLGG++FR++RV + ++ + V Sbjct: 43 EMHAGLASDGG--SKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRVLLGGKQERVV 100 Query: 106 SMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLP------VGFTFSFPCR 159 E E P +++ G +LF+ +A+ L F+ + +D LP +GFTF+FP + Sbjct: 101 KQEFEEVSIPPHLMTGGSDELFNFIAEALAKFV-ATECEDFHLPEGRQRELGFTFAFPVK 159 Query: 160 QSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGY 219 Q+ + LI WTK F G DVV LNKA+++ G D I A+VNDTVGT+ Y Sbjct: 160 QTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVG-LDMRIAALVNDTVGTLAGGRY 218 Query: 220 DDQQCEVGLIIGTGTNACYMEELRHIDLVEG---DEGRMCINTEWGAFGDDGSLEDIRTE 276 + +I+GTGTNA Y+E I G G M IN EWG F S TE Sbjct: 219 YNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNF---RSSHLPLTE 275 Query: 277 FDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNT 336 FD LD SLNPG+Q+ EK++SGMY+GE++R +L+KMA++ F + +L T Sbjct: 276 FDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSKLRIPFIIRT 335 Query: 337 SDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVS---------VQHICTIVSFRSANLVA 387 +SA+ D L +G + D+ V V +C I++ R A L A Sbjct: 336 PHMSAMHND------TSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATRGARLSA 389 Query: 388 ATLGAILNRL-RD-NKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPD---SDVRF 442 A + IL +L RD K ++ + +DG L++ + Q+S +L+ L+ D V Sbjct: 390 AGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEASGSVEV 449 Query: 443 LLSESGTGKGAAMVTA 458 S G+G GAA++ A Sbjct: 450 THSNDGSGIGAALLAA 465 >3B8A-X nrPDB Length = 485 Score = 246 bits (628), Expect = 4e-65, Method: Compositional matrix adjust. Identities = 162/469 (34%), Positives = 264/469 (56%), Gaps = 38/469 (8%) Query: 459 VAYRLAEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRS 518 V L ++ Q+E+ F + +TL +V K E+ GL K+ + + M+P +V Sbjct: 19 VPKELMDEIHQLEDM---FTVDSETLRKVVKHFIDELNKGLTKKGGN---IPMIPGWVME 72 Query: 519 IPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTG--DELFD 576 P G E G++LA+DLGGTN RV+LVK+ T + Y +P + M+ T +EL+ Sbjct: 73 FPTGKESGNYLAIDLGGTNLRVVLVKLSG--NHTFDTTQSKYKLPHD-MRTTKHQEELWS 129 Query: 577 HIVSCISDFL---DYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDV 633 I + DF+ + + K +PLGFTFS+P Q ++ GIL WTKGF + EGHDV Sbjct: 130 FIADSLKDFMVEQELLNTKD-TLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDV 188 Query: 634 ASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNV 693 LL++ + +RE +++VA++NDTVGT++ Y +P ++G+I GTG N + + + ++ Sbjct: 189 VPLLQNEISKRE-LPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDI 247 Query: 694 EMVEG-------NQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMIS 746 E +EG + M IN E+G+F DN L RT +D VDE S G+Q FEKM S Sbjct: 248 EKLEGKLADDIPSNSPMAINCEYGSF-DNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTS 306 Query: 747 GMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQ-VRAILQ 805 G YLGE++R +L++ +KG + + Q LK I +T + ++IE D L+ I Q Sbjct: 307 GYYLGELLRLVLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQ 366 Query: 806 Q-LGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTL 864 + G+ +T + L++ +C ++ RAA+L G+AA+ +K RG + + DG++ Sbjct: 367 KDFGVKTTLPERKLIRRLCELIGTRAARLAVCGIAAICQK----RG--YKTGHIAADGSV 420 Query: 865 YKLHPHFSRIMHQTVKEL------SPKCTVSFLLSEDGSGKGAALITAV 907 Y +P F + ++++ + K ++ + +EDGSG GAA+I A+ Sbjct: 421 YNKYPGFKEAAAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIAAL 469 Score = 209 bits (533), Expect = 4e-54, Method: Compositional matrix adjust. Identities = 145/451 (32%), Positives = 245/451 (54%), Gaps = 32/451 (7%) Query: 34 EILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRIL 93 E L ++ F E+ GL++ ++ M+P +V P G E G+++A+DLGG++ R++ Sbjct: 39 ETLRKVVKHFIDELNKGLTKK---GGNIPMIPGWVMEFPTGKESGNYLAIDLGGTNLRVV 95 Query: 94 RVQVNHEKNQNVSMESEIYDTPENI-VHGSGTQLFDHVADCLGDFMEKKKIKDKK--LPV 150 V+++ N Y P ++ +L+ +AD L DFM ++++ + K LP+ Sbjct: 96 LVKLS--GNHTFDTTQSKYKLPHDMRTTKHQEELWSFIADSLKDFMVEQELLNTKDTLPL 153 Query: 151 GFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDT 210 GFTFS+P Q+KI+E +L WTK F VEG DVV LL I KR + IVA++NDT Sbjct: 154 GFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEISKR-ELPIEIVALINDT 212 Query: 211 VGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEG-------DEGRMCINTEWGA 263 VGT++ Y D + ++G+I GTG N + + + I+ +EG M IN E+G+ Sbjct: 213 VGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKLADDIPSNSPMAINCEYGS 272 Query: 264 FGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGR 323 F D+ L RT++D +D S PG+Q FEKM SG Y+GEL+RL+L+++ ++GL+ + + Sbjct: 273 F-DNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLRLVLLELNEKGLMLKDQ 331 Query: 324 ITPELLTRGKFNTSDVSAIEKDK-EGIQNAKEILTR-LGVEPSDVDCVSVQHICTIVSFR 381 +L +TS + IE D E +++ +I + GV+ + + ++ +C ++ R Sbjct: 332 DLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQKDFGVKTTLPERKLIRRLCELIGTR 391 Query: 382 SANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRL------V 435 +A L + AI + G + DGS+Y +P + K LR + Sbjct: 392 AARLAVCGIAAICQKRGYKTG------HIAADGSVYNKYPGFKEAAAKGLRDIYGWTGDA 445 Query: 436 PDSDVRFLLSESGTGKGAAMVTAVA-YRLAE 465 + + +E G+G GAA++ A++ R+AE Sbjct: 446 SKDPITIVPAEDGSGAGAAVIAALSEKRIAE 476 >2YHX-A nrPDB Length = 457 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 34/179 (18%), Positives = 72/179 (40%), Gaps = 6/179 (3%) Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVH 120 + M+P +V G++ G F+A+ +GG ++ + + + ++ + Sbjct: 44 IPMVPGWVLKQVSGAQAGSFLAIVMGGGDLEVILISLAGRQESSIXASRSLAAAMSTTAI 103 Query: 121 GSGTQLFDHVADC-LGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASG 179 S L+ + A + +P+GFTF + + + + F + Sbjct: 104 PS--DLWGNXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAX 161 Query: 180 VEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACY 238 + ++ + A GD + VA + D+ G + Y D ++G+I G+G NA Y Sbjct: 162 LX--KLISAMXNAXFPAGDXXXS-VADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAY 217 Score = 40.4 bits (93), Expect = 0.004, Method: Compositional matrix adjust. Identities = 37/178 (20%), Positives = 73/178 (41%), Gaps = 4/178 (2%) Query: 509 VKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQ 568 + M+P +V G + G FLA+ +GG + V+L+ + +G++ + ++ + + Sbjct: 44 IPMVPGWVLKQVSGAQAGSFLAIVMGGGDLEVILISL-AGRQESSIXASRSLAAAMSTTA 102 Query: 569 GTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDC 628 D + S + +PLGFTF + + G + F Sbjct: 103 IPSDLWGNXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAXL 162 Query: 629 EGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACY 686 + S + +A + VA + D+ G + Y + ++G+I G+G NA Y Sbjct: 163 X--KLISAMXNAXFPAGDXXXS-VADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAY 217 >1HKG-A nrPDB Length = 457 Score = 39.7 bits (91), Expect = 0.007, Method: Compositional matrix adjust. Identities = 35/179 (19%), Positives = 72/179 (40%), Gaps = 6/179 (3%) Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVH 120 + M+P +V GS+ G F+A+ +GG ++ + + + ++ + + Sbjct: 44 IPMVPGWVLKQVXGSQAGSFLAIVMGGGDLEVILIXLAGYQESSIXASRSLAASMXTTAI 103 Query: 121 GSGTQLFDHVADC-LGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASG 179 S L+ + A + +P+GFTF + + + + F + Sbjct: 104 PS--DLWGNXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAX 161 Query: 180 VEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACY 238 + ++ + A GD VA + D+ G + Y D ++G+I G+G NA Y Sbjct: 162 LX--KLISAMXNAXFPAGD-XXXXVADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAY 217 Score = 37.7 bits (86), Expect = 0.022, Method: Compositional matrix adjust. Identities = 37/178 (20%), Positives = 73/178 (41%), Gaps = 4/178 (2%) Query: 509 VKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQ 568 + M+P +V G++ G FLA+ +GG + V+L+ + +G + + ++ + + Sbjct: 44 IPMVPGWVLKQVXGSQAGSFLAIVMGGGDLEVILIXL-AGYQESSIXASRSLAASMXTTA 102 Query: 569 GTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDC 628 D + S + +PLGFTF + + G + F Sbjct: 103 IPSDLWGNXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAXL 162 Query: 629 EGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACY 686 + S + +A + VA + D+ G + Y + ++G+I G+G NA Y Sbjct: 163 X--KLISAMXNAXFPAGD-XXXXVADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAY 217 >4FDG-B nrPDB Length = 692 Score = 33.1 bits (74), Expect = 0.58, Method: Compositional matrix adjust. Identities = 20/59 (33%), Positives = 29/59 (49%), Gaps = 2/59 (3%) Query: 837 GMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSED 895 G+ V+E +R+ R D + + +DG L K+ P RI T K + P C F ED Sbjct: 108 GIPRVIE-LRKIRSTD-IGKLITIDGILVKVTPVKERIYKATYKHIHPDCMQEFEWPED 164 >3F9V-A nrPDB Length = 595 Score = 33.1 bits (74), Expect = 0.63, Method: Compositional matrix adjust. Identities = 20/59 (33%), Positives = 29/59 (49%), Gaps = 2/59 (3%) Query: 837 GMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSED 895 G+ V+E +R+ R D + + +DG L K+ P RI T K + P C F ED Sbjct: 96 GIPRVIE-LRKIRSTD-IGKLITIDGILVKVTPVKERIYKATYKHIHPDCMQEFEWPED 152 >4R7Y-A nrPDB Length = 613 Score = 32.7 bits (73), Expect = 0.74, Method: Compositional matrix adjust. Identities = 20/59 (33%), Positives = 29/59 (49%), Gaps = 2/59 (3%) Query: 837 GMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSED 895 G+ V+E +R+ R D + + +DG L K+ P RI T K + P C F ED Sbjct: 103 GIPRVIE-LRKIRSTD-IGKLITIDGILVKVTPVKERIYKATYKHIHPDCMQEFEWPED 159 >3Q5R-A nrPDB Length = 284 Score = 32.3 bits (72), Expect = 0.93, Method: Composition-based stats. Identities = 15/32 (46%), Positives = 20/32 (62%) Query: 465 EQHRQIEETLAHFRLSKQTLMEVKKRLRTEME 496 EQ RQI E L +QT+ VKKR++ +ME Sbjct: 86 EQERQIREKLDFLSALEQTISLVKKRMKRQME 117 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1BG3-A nrPDB 1449 0.0 4FOI-A nrPDB 1445 0.0 5HFU-A nrPDB 1392 0.0 3W0L-A nrPDB 660 0.0 4DCH-A nrPDB 646 0.0 3HM8-A nrPDB 643 0.0 3O1W-A nrPDB 600 e-171 1BDG-A nrPDB 584 e-167 1IG8-A nrPDB 575 e-164 3B8A-X nrPDB 563 e-160 5ZQT-A nrPDB 551 e-157 4QS9-A nrPDB 528 e-150 Sequences not found previously or not previously below threshold: 2YHX-A nrPDB 124 2e-28 1HKG-A nrPDB 122 1e-27 3ZR5-A nrPDB 35 0.19 2BWY-A nrPDB 33 0.80 4NK4-A nrPDB 31 1.7 5ZI1-A nrPDB 30 3.6 >1BG3-A nrPDB Length = 918 Score = 1449 bits (3752), Expect = 0.0, Method: Composition-based stats. Identities = 918/918 (100%), Positives = 918/918 (100%) Query: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTAS 60 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTAS Sbjct: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTAS 60 Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVH 120 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVH Sbjct: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVH 120 Query: 121 GSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGV 180 GSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGV Sbjct: 121 GSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGV 180 Query: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYME 240 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYME Sbjct: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYME 240 Query: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGM 300 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGM Sbjct: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGM 300 Query: 301 YMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLG 360 YMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLG Sbjct: 301 YMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLG 360 Query: 361 VEPSDVDCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMH 420 VEPSDVDCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMH Sbjct: 361 VEPSDVDCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMH 420 Query: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLS 480 PQYSRRFHKTLRRLVPDSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLS Sbjct: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLS 480 Query: 481 KQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRV 540 KQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRV Sbjct: 481 KQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRV 540 Query: 541 LLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGF 600 LLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGF Sbjct: 541 LLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGF 600 Query: 601 TFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVG 660 TFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVG Sbjct: 601 TFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVG 660 Query: 661 TMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDD 720 TMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDD Sbjct: 661 TMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDD 720 Query: 721 IRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRG 780 IRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRG Sbjct: 721 IRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRG 780 Query: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAA 840 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAA Sbjct: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAA 840 Query: 841 VVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKG 900 VVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKG Sbjct: 841 VVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKG 900 Query: 901 AALITAVGVRLRGDPSIA 918 AALITAVGVRLRGDPSIA Sbjct: 901 AALITAVGVRLRGDPSIA 918 >4FOI-A nrPDB Length = 917 Score = 1445 bits (3741), Expect = 0.0, Method: Composition-based stats. Identities = 849/916 (92%), Positives = 892/916 (97%) Query: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTAS 60 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDE LIDI+TRF+KEMKNGLSRD+NPTA+ Sbjct: 1 MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTAT 60 Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVH 120 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNV MESE+YDTPENIVH Sbjct: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH 120 Query: 121 GSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGV 180 GSG+QLFDHVA+CLGDFMEK+KIKDKKLPVGFTFSFPC+QSKIDEA+LITWTKRFKASGV Sbjct: 121 GSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGV 180 Query: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYME 240 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQ CEVGLIIGTGTNACYME Sbjct: 181 EGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYME 240 Query: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGM 300 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRE+DRGSLNPGKQLFEKMVSGM Sbjct: 241 ELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGM 300 Query: 301 YMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLG 360 Y+GELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEK+KEG+ NAKEILTRLG Sbjct: 301 YLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLG 360 Query: 361 VEPSDVDCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMH 420 VEPSD DCVSVQH+CTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGV+GSLYK H Sbjct: 361 VEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVNGSLYKTH 420 Query: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLS 480 PQYSRRFHKTLRRLVPDSDVRFLLSESG+GKGAAMVTAVAYRLAEQHRQIEETLAHF L+ Sbjct: 421 PQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLT 480 Query: 481 KQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRV 540 K L+EVKKR+R EME+GLRK+T++ A VKMLPSFVR PDGTE+GDFLALDLGGTNFRV Sbjct: 481 KDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRV 540 Query: 541 LLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGF 600 LLVKIRSGKKRTVEMHNKIY+IP+EIMQGTG+ELFDHIVSCISDFLDYMGIKGPRMPLGF Sbjct: 541 LLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGF 600 Query: 601 TFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVG 660 TFSFPC QT+LD GILI+WTKGFKATDC GHDV +LLRDA+KRREEFDLDVVAVVNDTVG Sbjct: 601 TFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVG 660 Query: 661 TMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDD 720 TMMTCAYEEPTCE+GLIVGTG+NACYMEEMKNVEMVEG+QGQMCINMEWGAFGDNGCLDD Sbjct: 661 TMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDD 720 Query: 721 IRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRG 780 IRT +D++VDEYSLN+GKQR+EKMISGMYLGEIVRNILIDFTKKGFLFRGQISE LKTRG Sbjct: 721 IRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRG 780 Query: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAA 840 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVS+RAAQLCGAGMAA Sbjct: 781 IFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAA 840 Query: 841 VVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKG 900 VV+KIRENRGLD LNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKC VSFLLSEDGSGKG Sbjct: 841 VVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKG 900 Query: 901 AALITAVGVRLRGDPS 916 AALITAVGVRLR + S Sbjct: 901 AALITAVGVRLRTEAS 916 >5HFU-A nrPDB Length = 923 Score = 1392 bits (3603), Expect = 0.0, Method: Composition-based stats. Identities = 653/896 (72%), Positives = 778/896 (86%) Query: 17 DQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSE 76 DQV+K+D+YLY MRLSDE L++I RF+KEM+ GL +PTA+VKMLPTFVRS PDG+E Sbjct: 23 DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTE 82 Query: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGD 136 G+F+ALDLGG++FR+L V+V Q V ME++IY PE+I+ GSGTQLFDH+A+CL + Sbjct: 83 HGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLAN 142 Query: 137 FMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKR 196 FM+K +IKDKKLP+GFTFSFPC Q+K+DE+ L++WTK FK+SGVEG DVV L+ KAI++R Sbjct: 143 FMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRR 202 Query: 197 GDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256 GD+D +IVAVVNDTVGTMMTCGYDD CE+GLI+GTG+NACYMEE+RHID+VEGDEGRMC Sbjct: 203 GDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMC 262 Query: 257 INTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKE 316 IN EWGAFGDDGSL DIRTEFD+E+D GSLNPGKQLFEKM+SGMYMGELVRLILVKMAKE Sbjct: 263 INMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKE 322 Query: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVSVQHICT 376 LLF G+++PELL G+F T D+S IE +K+GI+ A+E+L RLG++P+ DCV+ IC Sbjct: 323 ELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQ 382 Query: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVP 436 IVS RSA+L AATL A+L R+++NKG RLR+T+GVDGS+YK HP +++R HKT+RRLVP Sbjct: 383 IVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVP 442 Query: 437 DSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLSKQTLMEVKKRLRTEME 496 DVRFL SE G+GKGAAMVTAVAYRLA+QHR ++TL H +LS L+EVK+R++ EME Sbjct: 443 GCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEME 502 Query: 497 MGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMH 556 GL KET++ A VKMLP++V + PDGTE GDFLALDLGGTNFRVLLV++R+GK VEMH Sbjct: 503 RGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMH 562 Query: 557 NKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQTNLDCGIL 616 NKIY+IP E+M GTGDELFDHIV CI+DFL+YMG+KG +PLGFTFSFPC Q +LD IL Sbjct: 563 NKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESIL 622 Query: 617 ISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGL 676 + WTKGFKA+ CEG DV +LL++A+ RREEFDLDVVAVVNDTVGTMMTC +E+P CE+GL Sbjct: 623 LKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGL 682 Query: 677 IVGTGTNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNS 736 IVGTG+NACYMEEM+NVE+VEG +G+MC+NMEWGAFGDNGCLDD RT+FD VDE SLN Sbjct: 683 IVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNP 742 Query: 737 GKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLA 796 GKQRFEKMISGMYLGEIVRNILIDFTK+G LFRG+ISE LKTRGIFETKFLSQIESD LA Sbjct: 743 GKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLA 802 Query: 797 LLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLNV 856 LLQVRAILQ LGL STCDDSI+VK VC VV++RAAQLCGAGMAAVV++IRENRGLD L V Sbjct: 803 LLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKV 862 Query: 857 TVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKGAALITAVGVRLR 912 TVGVDGTLYKLHPHF+++MH+TVK+L+PKC VSFL SEDGSGKGAALITAV R+R Sbjct: 863 TVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFLQSEDGSGKGAALITAVACRIR 918 Score = 615 bits (1585), Expect = e-176, Method: Composition-based stats. Identities = 243/449 (54%), Positives = 337/449 (75%) Query: 17 DQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSE 76 DQ + K L ++LS + L+++ R K EM+ GLS++ + +A VKMLPT+V + PDG+E Sbjct: 471 DQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTE 530 Query: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGD 136 KGDF+ALDLGG++FR+L V+V + K V M ++IY P+ ++HG+G +LFDH+ C+ D Sbjct: 531 KGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIAD 590 Query: 137 FMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKR 196 F+E +K LP+GFTFSFPC+Q+ +DE++L+ WTK FKASG EG DVV LL +AI +R Sbjct: 591 FLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRR 650 Query: 197 GDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMC 256 ++D ++VAVVNDTVGTMMTCG++D CEVGLI+GTG+NACYMEE+R+++LVEG+EGRMC Sbjct: 651 EEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMC 710 Query: 257 INTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKE 316 +N EWGAFGD+G L+D RTEFD +D SLNPGKQ FEKM+SGMY+GE+VR IL+ K Sbjct: 711 VNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKR 770 Query: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVSVQHICT 376 GLLF GRI+ L TRG F T +S IE D + + IL LG+E + D + V+ +CT Sbjct: 771 GLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCT 830 Query: 377 IVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVP 436 +V+ R+A L A + A+++R+R+N+G L+ TVGVDG+LYK+HP +++ H+T++ L P Sbjct: 831 VVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAP 890 Query: 437 DSDVRFLLSESGTGKGAAMVTAVAYRLAE 465 DV FL SE G+GKGAA++TAVA R+ E Sbjct: 891 KCDVSFLQSEDGSGKGAALITAVACRIRE 919 Score = 594 bits (1531), Expect = e-170, Method: Composition-based stats. Identities = 260/448 (58%), Positives = 349/448 (77%) Query: 464 AEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGT 523 ++Q +++++ L H RLS +TL+E+ KR R EME GL T+ A VKMLP+FVRS PDGT Sbjct: 22 SDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGT 81 Query: 524 EHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCIS 583 EHG+FLALDLGGTNFRVL VK+ + VEM N+IY+IP +IM+G+G +LFDHI C++ Sbjct: 82 EHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLA 141 Query: 584 DFLDYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKR 643 +F+D + IK ++PLGFTFSFPCHQT LD L+SWTKGFK++ EG DV +L+R A++R Sbjct: 142 NFMDKLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQR 201 Query: 644 REEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQM 703 R +FD+D+VAVVNDTVGTMMTC Y++ CEIGLIVGTG+NACYMEEM++++MVEG++G+M Sbjct: 202 RGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRM 261 Query: 704 CINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTK 763 CINMEWGAFGD+G L+DIRT+FD+ +D SLN GKQ FEKMISGMY+GE+VR IL+ K Sbjct: 262 CINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAK 321 Query: 764 KGFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVC 823 + LF G++S L G FETK +S IE ++ + + R +L +LGL+ T +D + +C Sbjct: 322 EELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRIC 381 Query: 824 GVVSKRAAQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELS 883 +VS R+A LC A +AAV+++I+EN+G + L T+GVDG++YK HPHF++ +H+TV+ L Sbjct: 382 QIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLV 441 Query: 884 PKCTVSFLLSEDGSGKGAALITAVGVRL 911 P C V FL SEDGSGKGAA++TAV RL Sbjct: 442 PGCDVRFLRSEDGSGKGAAMVTAVAYRL 469 >3W0L-A nrPDB Length = 458 Score = 660 bits (1704), Expect = 0.0, Method: Composition-based stats. Identities = 241/447 (53%), Positives = 329/447 (73%), Gaps = 2/447 (0%) Query: 467 HRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHG 526 ++++ L+ F L ++ L + R++ EME GL ETN +A+VKMLP++VRS PDG+E G Sbjct: 6 QNEVDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSEVG 65 Query: 527 DFLALDLGGTNFRVLLVKIRSG--KKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISD 584 DFLALDLGGTNFRV+LVK+ + VE +K+YSIP++ M GT + LFD+I CISD Sbjct: 66 DFLALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPVDAMTGTAEMLFDYIAECISD 125 Query: 585 FLDYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRR 644 +LD +K ++PLGFTFSFP ++D GIL++WTKGFKA+ EG++V LLRDA+KRR Sbjct: 126 YLDQQNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRR 185 Query: 645 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMC 704 +F++DVVA+VNDTV TM++C YE+ CE+GLIVGTG NACYMEEM NVE+VEG +G+MC Sbjct: 186 GDFEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGEEGRMC 245 Query: 705 INMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKK 764 +N EWGAFGD G L+D R ++D+VVDE SLN G+Q +EKMI G Y+GE+VR +LI + Sbjct: 246 VNTEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLIKMVNE 305 Query: 765 GFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCG 824 LF G+ SE LKTRG FET+F+SQIE+D Q IL+ LG+ +T D V+ C Sbjct: 306 NLLFGGESSEKLKTRGAFETQFVSQIEADTSDFKQTLNILRTLGVQATIGDCHAVRLACE 365 Query: 825 VVSKRAAQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSP 884 VS RAA +C AG+A ++ ++R++R + L +TVGVDG++YKLHP F H TV +L+ Sbjct: 366 SVSTRAAIMCSAGLAGILNRMRQSRREELLRITVGVDGSVYKLHPSFKDKFHATVLKLTS 425 Query: 885 KCTVSFLLSEDGSGKGAALITAVGVRL 911 C ++F+ SE+GSG+GAALI+AV ++ Sbjct: 426 GCEITFIQSEEGSGRGAALISAVAYKM 452 Score = 660 bits (1703), Expect = 0.0, Method: Composition-based stats. Identities = 230/446 (51%), Positives = 319/446 (71%), Gaps = 2/446 (0%) Query: 21 KIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDF 80 ++D+ L L +E L ++ R + EM+ GL + N ASVKMLPT+VRS PDGSE GDF Sbjct: 8 EVDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSEVGDF 67 Query: 81 IALDLGGSSFRILRVQVNH--EKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFM 138 +ALDLGG++FR++ V+V E V + ++Y P + + G+ LFD++A+C+ D++ Sbjct: 68 LALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPVDAMTGTAEMLFDYIAECISDYL 127 Query: 139 EKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGD 198 +++ +K KKLP+GFTFSFP R ID+ +L+ WTK FKASG EG +VV LL AIK+RGD Sbjct: 128 DQQNMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGD 187 Query: 199 YDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCIN 258 ++ ++VA+VNDTV TM++C Y+D CEVGLI+GTG NACYMEE+ +++LVEG+EGRMC+N Sbjct: 188 FEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGEEGRMCVN 247 Query: 259 TEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGL 318 TEWGAFGD G LED R E+DR +D SLNPG+QL+EKM+ G YMGELVRL+L+KM E L Sbjct: 248 TEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLIKMVNENL 307 Query: 319 LFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVSVQHICTIV 378 LF G + +L TRG F T VS IE D + IL LGV+ + DC +V+ C V Sbjct: 308 LFGGESSEKLKTRGAFETQFVSQIEADTSDFKQTLNILRTLGVQATIGDCHAVRLACESV 367 Query: 379 SFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDS 438 S R+A + +A L ILNR+R ++ LR TVGVDGS+YK+HP + +FH T+ +L Sbjct: 368 STRAAIMCSAGLAGILNRMRQSRREELLRITVGVDGSVYKLHPSFKDKFHATVLKLTSGC 427 Query: 439 DVRFLLSESGTGKGAAMVTAVAYRLA 464 ++ F+ SE G+G+GAA+++AVAY++A Sbjct: 428 EITFIQSEEGSGRGAALISAVAYKMA 453 >4DCH-A nrPDB Length = 473 Score = 646 bits (1667), Expect = 0.0, Method: Composition-based stats. Identities = 237/453 (52%), Positives = 338/453 (74%), Gaps = 2/453 (0%) Query: 460 AYRLAEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSI 519 A A + ++E+ LA F+L ++ L +V +R++ EM+ GLR ET+ +A+VKMLP++VRS Sbjct: 6 ARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRST 65 Query: 520 PDGTEHGDFLALDLGGTNFRVLLVKIRSG--KKRTVEMHNKIYSIPLEIMQGTGDELFDH 577 P+G+E GDFL+LDLGGTNFRV+LVK+ G + +V+ +++YSIP + M GT + LFD+ Sbjct: 66 PEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDY 125 Query: 578 IVSCISDFLDYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLL 637 I CISDFLD +K ++PLGFTFSFP ++D GIL++WTKGFKA+ EG++V LL Sbjct: 126 ISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLL 185 Query: 638 RDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVE 697 RDA+KRR +F++DVVA+VNDTV TM++C YE+ CE+G+IVGTG NACYMEEM+NVE+VE Sbjct: 186 RDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVE 245 Query: 698 GNQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNI 757 G++G+MC+N EWGAFGD+G LD+ ++D++VDE S N G+Q +EK+I G Y+GE+VR + Sbjct: 246 GDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLV 305 Query: 758 LIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSI 817 L+ + LF G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D Sbjct: 306 LLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCD 365 Query: 818 LVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQ 877 +V+ C VS RAA +C AG+A V+ ++RE+R D + +TVGVDG++YKLHP F H Sbjct: 366 IVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHA 425 Query: 878 TVKELSPKCTVSFLLSEDGSGKGAALITAVGVR 910 +V+ L+P C ++F+ SE+GSG+GAAL++AV + Sbjct: 426 SVRRLTPSCEITFIESEEGSGRGAALVSAVACK 458 Score = 641 bits (1654), Expect = 0.0, Method: Composition-based stats. Identities = 226/454 (49%), Positives = 328/454 (72%), Gaps = 2/454 (0%) Query: 20 KKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGD 79 +K+++ L +L +E L ++ R +KEM GL + + ASVKMLPT+VRS P+GSE GD Sbjct: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73 Query: 80 FIALDLGGSSFRILRVQVNH--EKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDF 137 F++LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD++++C+ DF Sbjct: 74 FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 133 Query: 138 MEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRG 197 ++K ++K KKLP+GFTFSFP R ID+ +L+ WTK FKASG EG +VV LL AIK+RG Sbjct: 134 LDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 193 Query: 198 DYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCI 257 D++ ++VA+VNDTV TM++C Y+D QCEVG+I+GTG NACYMEE+++++LVEGDEGRMC+ Sbjct: 194 DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCV 253 Query: 258 NTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEG 317 NTEWGAFGD G L++ E+DR +D S NPG+QL+EK++ G YMGELVRL+L+++ E Sbjct: 254 NTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDEN 313 Query: 318 LLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVSVQHICTI 377 LLF G + +L TRG F T VS +E D + IL+ LG+ PS DC V+ C Sbjct: 314 LLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACES 373 Query: 378 VSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPD 437 VS R+A++ +A L ++NR+R+++ +R TVGVDGS+YK+HP + RFH ++RRL P Sbjct: 374 VSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPS 433 Query: 438 SDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIE 471 ++ F+ SE G+G+GAA+V+AVA + A Q+E Sbjct: 434 CEITFIESEEGSGRGAALVSAVACKKACMLGQLE 467 >3HM8-A nrPDB Length = 445 Score = 643 bits (1658), Expect = 0.0, Method: Composition-based stats. Identities = 288/445 (64%), Positives = 352/445 (79%), Gaps = 7/445 (1%) Query: 467 HRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHG 526 R +EETLA FRL+ L V+ ++R M GLR ++++MLP+FVR+ PDG+E G Sbjct: 3 RRLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLR---GEASSLRMLPTFVRATPDGSERG 59 Query: 527 DFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFL 586 DFLALDLGGTNFRVLLV++ +G V++ ++IYSIP + QG+G +LFDHIV CI DF Sbjct: 60 DFLALDLGGTNFRVLLVRVTTG----VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQ 115 Query: 587 DYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREE 646 G+ G +PLGFTFSFPC Q LD GIL++WTKGFKA+DCEG DV SLLR+A+ RR+ Sbjct: 116 QKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQA 175 Query: 647 FDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMCIN 706 +L+VVA+VNDTVGTMM+C YE+P CEIGLIVGTGTNACYMEE++NV V G+ G+MCIN Sbjct: 176 VELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCIN 235 Query: 707 MEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGF 766 MEWGAFGD+G L + T FD VD+ S+N GKQRFEKMISGMYLGEIVR+IL+ T G Sbjct: 236 MEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGV 295 Query: 767 LFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVV 826 LFRGQ + L+TR IF+TKFLS+IESD LAL QVRAIL+ LGL T DD+++V VC V Sbjct: 296 LFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAV 355 Query: 827 SKRAAQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKC 886 S+RAAQLCGAG+AAVVEKIRENRGL+ L V+VGVDGTLYKLHP FS ++ TV+EL+P+C Sbjct: 356 SQRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRC 415 Query: 887 TVSFLLSEDGSGKGAALITAVGVRL 911 V+FL SEDGSGKGAAL+TAV RL Sbjct: 416 VVTFLQSEDGSGKGAALVTAVACRL 440 Score = 622 bits (1604), Expect = e-178, Method: Composition-based stats. Identities = 230/449 (51%), Positives = 310/449 (69%), Gaps = 7/449 (1%) Query: 20 KKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGD 79 + +++ L RL+ + L + + +K M GL +S++MLPTFVR+ PDGSE+GD Sbjct: 4 RLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLR---GEASSLRMLPTFVRATPDGSERGD 60 Query: 80 FIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFME 139 F+ALDLGG++FR+L V+V V + SEIY PE + GSG QLFDH+ DC+ DF + Sbjct: 61 FLALDLGGTNFRVLLVRVT----TGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQ 116 Query: 140 KKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDY 199 K+ + + LP+GFTFSFPCRQ +D+ +L+ WTK FKAS EG DVV LL +AI +R Sbjct: 117 KQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAV 176 Query: 200 DANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 259 + N+VA+VNDTVGTMM+CGY+D +CE+GLI+GTGTNACYMEELR++ V GD GRMCIN Sbjct: 177 ELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINM 236 Query: 260 EWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLL 319 EWGAFGDDGSL + T FD +D+ S+NPGKQ FEKM+SGMY+GE+VR IL+ + G+L Sbjct: 237 EWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVL 296 Query: 320 FEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVSVQHICTIVS 379 F G+ L TR F T +S IE D ++ + IL LG+ + D + V +C VS Sbjct: 297 FRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVS 356 Query: 380 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDSD 439 R+A L A + A++ ++R+N+G L +VGVDG+LYK+HP++S T+R L P Sbjct: 357 QRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCV 416 Query: 440 VRFLLSESGTGKGAAMVTAVAYRLAEQHR 468 V FL SE G+GKGAA+VTAVA RLA+ R Sbjct: 417 VTFLQSEDGSGKGAALVTAVACRLAQLTR 445 >3O1W-A nrPDB Length = 485 Score = 600 bits (1546), Expect = e-171, Method: Composition-based stats. Identities = 160/481 (33%), Positives = 255/481 (53%), Gaps = 31/481 (6%) Query: 448 GTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKA 507 G K A ++A A QI F +S + + + K +E++ GL K+ + Sbjct: 5 GPKKPPARKGSMADVPANLMEQIHGLETLFTVSSEKMRSIVKHFISELDKGLSKKGGN-- 62 Query: 508 TVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIM 567 + M+P +V P G E GDFLALDLGGTN RV+LVK+ G + Y +P + Sbjct: 63 -IPMIPGWVVEYPTGKETGDFLALDLGGTNLRVVLVKL--GGNHDFDTTQNKYRLPDHLR 119 Query: 568 QGTGDELFDHIVSCISDFLDYMGIKGPR--MPLGFTFSFPCHQTNLDCGILISWTKGFKA 625 GT ++L+ I C+ +F+D G +PLGFTFS+P Q ++ G+L WTKGF Sbjct: 120 TGTSEQLWSFIAKCLKEFVDEWYPDGVSEPLPLGFTFSYPASQKKINSGVLQRWTKGFDI 179 Query: 626 TDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNAC 685 EGHDV +L++ +++ ++VVA++NDT GT++ Y +P ++G+I+GTG N Sbjct: 180 EGVEGHDVVPMLQEQIEKLN-IPINVVALINDTTGTLVASLYTDPQTKMGIIIGTGVNGA 238 Query: 686 YMEEMKNVEMVEG-------NQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGK 738 Y + + +E +EG M IN E+G+F DN L RT +D ++DE S G+ Sbjct: 239 YYDVVSGIEKLEGLLPEDIGPDSPMAINCEYGSF-DNEHLVLPRTKYDVIIDEESPRPGQ 297 Query: 739 QRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLALL 798 Q FEKM SG YLGEI+R +L+D GF+F+ Q LK + +T + S+IE D L Sbjct: 298 QAFEKMTSGYYLGEIMRLVLLDLYDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFENL 357 Query: 799 QVRAILQQLGLN--STCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLNV 856 + L + LN +T + L++ + +V RAA+L G++A+ +K + Sbjct: 358 EDTDDLFKTNLNIETTVVERKLIRKLAELVGTRAARLTVCGVSAICDKRG------YKTA 411 Query: 857 TVGVDGTLYKLHPHFSRIMHQTVKELS-------PKCTVSFLLSEDGSGKGAALITAVGV 909 + DG+++ +P + Q +K++ + + +EDGSG GAA+I + Sbjct: 412 HIAADGSVFNRYPGYKEKAAQALKDIYNWDVEKMEDHPIQLVAAEDGSGVGAAIIACLTQ 471 Query: 910 R 910 + Sbjct: 472 K 472 Score = 563 bits (1451), Expect = e-160, Method: Composition-based stats. Identities = 146/462 (31%), Positives = 249/462 (53%), Gaps = 31/462 (6%) Query: 19 VKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKG 78 +++I +S E + I+ F E+ GLS+ ++ M+P +V P G E G Sbjct: 24 MEQIHGLETLFTVSSEKMRSIVKHFISELDKGLSKK---GGNIPMIPGWVVEYPTGKETG 80 Query: 79 DFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFM 138 DF+ALDLGG++ R++ V++ N + Y P+++ G+ QL+ +A CL +F+ Sbjct: 81 DFLALDLGGTNLRVVLVKLGG--NHDFDTTQNKYRLPDHLRTGTSEQLWSFIAKCLKEFV 138 Query: 139 EKKKIK--DKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKR 196 ++ + LP+GFTFS+P Q KI+ VL WTK F GVEG DVV +L + I+K Sbjct: 139 DEWYPDGVSEPLPLGFTFSYPASQKKINSGVLQRWTKGFDIEGVEGHDVVPMLQEQIEKL 198 Query: 197 GDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEG------ 250 + N+VA++NDT GT++ Y D Q ++G+IIGTG N Y + + I+ +EG Sbjct: 199 -NIPINVVALINDTTGTLVASLYTDPQTKMGIIIGTGVNGAYYDVVSGIEKLEGLLPEDI 257 Query: 251 -DEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLI 309 + M IN E+G+F D+ L RT++D +D S PG+Q FEKM SG Y+GE++RL+ Sbjct: 258 GPDSPMAINCEYGSF-DNEHLVLPRTKYDVIIDEESPRPGQQAFEKMTSGYYLGEIMRLV 316 Query: 310 LVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDK-EGIQNAKEIL-TRLGVEPSDVD 367 L+ + G +F+ + +L +TS S IE D E +++ ++ T L +E + V+ Sbjct: 317 LLDLYDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFENLEDTDDLFKTNLNIETTVVE 376 Query: 368 CVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRF 427 ++ + +V R+A L + AI ++ + DGS++ +P Y + Sbjct: 377 RKLIRKLAELVGTRAARLTVCGVSAICDKRGYKT------AHIAADGSVFNRYPGYKEKA 430 Query: 428 HKTLRRL-------VPDSDVRFLLSESGTGKGAAMVTAVAYR 462 + L+ + + D ++ + +E G+G GAA++ + + Sbjct: 431 AQALKDIYNWDVEKMEDHPIQLVAAEDGSGVGAAIIACLTQK 472 >1BDG-A nrPDB Length = 451 Score = 584 bits (1506), Expect = e-167, Method: Composition-based stats. Identities = 210/451 (46%), Positives = 284/451 (62%), Gaps = 13/451 (2%) Query: 465 EQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTE 524 + ++ E L F LS E+ R+ M +GL+K TN K+++KM PS+V P+GTE Sbjct: 7 QLFEKVVEILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTE 66 Query: 525 HGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISD 584 G+FLALDLGGTN+RVL V + GK ++ + + Y IP E M G+G ELF +I ++D Sbjct: 67 TGNFLALDLGGTNYRVLSVTL-EGKGKSPRIQERTYCIPAEKMSGSGTELFKYIAETLAD 125 Query: 585 FLDYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRR 644 FL+ G+K + LGFTFSFPC Q L L+ WTKGF A EGH+VA LL+ + +R Sbjct: 126 FLENNGMKDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTELDKR 185 Query: 645 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEG-NQGQM 703 E ++ VAVVNDTVGT+ +CA E+P C +GLIVGTGTN Y+E+ VE+++G + ++ Sbjct: 186 E-LNVKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGVKEPEV 244 Query: 704 CINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTK 763 IN EWGAFG+ G LD RT FDK +D SL+ GKQ +EKM+SGMYLGE+VR+I++ + Sbjct: 245 VINTEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYLVE 304 Query: 764 KGFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSI---LVK 820 + LFRG + E LK R T++L+ +E D LL + L+ + I +V+ Sbjct: 305 QKILFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEPIDNRIVR 364 Query: 821 TVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVK 880 C +V KRAA L GAG+A ++ +I + VTVGVDG+LYK HP F M V Sbjct: 365 YACEMVVKRAAYLAGAGIACILRRINRS------EVTVGVDGSLYKFHPKFCERMTDMVD 418 Query: 881 ELSPKCTVSFL-LSEDGSGKGAALITAVGVR 910 +L PK T L LSEDGSGKGAA I A R Sbjct: 419 KLKPKNTRFCLRLSEDGSGKGAAAIAASCTR 449 Score = 554 bits (1427), Expect = e-158, Method: Composition-based stats. Identities = 192/458 (41%), Positives = 279/458 (60%), Gaps = 20/458 (4%) Query: 14 LKDDQV-KKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIP 72 D Q+ +K+ + L LS +I R + M+ GL + N +S+KM P++V P Sbjct: 3 FSDQQLFEKVVEILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTP 62 Query: 73 DGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVAD 132 +G+E G+F+ALDLGG+++R+L V + + ++ ++ Y P + GSGT+LF ++A+ Sbjct: 63 NGTETGNFLALDLGGTNYRVLSVTLEGKG-KSPRIQERTYCIPAEKMSGSGTELFKYIAE 121 Query: 133 CLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKA 192 L DF+E +KDKK +GFTFSFPC Q + A L+ WTK F A GVEG +V +LL Sbjct: 122 TLADFLENNGMKDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTE 181 Query: 193 IKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEG-D 251 + KR + + VAVVNDTVGT+ +C +D +C VGLI+GTGTN Y+E+ ++L++G Sbjct: 182 LDKR-ELNVKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGVK 240 Query: 252 EGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILV 311 E + INTEWGAFG+ G L+ RT+FD+ +D SL+PGKQL+EKMVSGMY+GELVR I+V Sbjct: 241 EPEVVINTEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIV 300 Query: 312 KMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEG-IQNAKEILTR----LGVEPSDV 366 + ++ +LF G + L R T ++ +E+D + N +LT VEP + Sbjct: 301 YLVEQKILFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEP--I 358 Query: 367 DCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRR 426 D V++ C +V R+A L A + IL R+ R TVGVDGSLYK HP++ R Sbjct: 359 DNRIVRYACEMVVKRAAYLAGAGIACILRRIN------RSEVTVGVDGSLYKFHPKFCER 412 Query: 427 FHKTLRRLVPDSDVRFL--LSESGTGKGAAMVTAVAYR 462 + +L P + RF LSE G+GKGAA + A R Sbjct: 413 MTDMVDKLKPK-NTRFCLRLSEDGSGKGAAAIAASCTR 449 >1IG8-A nrPDB Length = 486 Score = 575 bits (1482), Expect = e-164, Method: Composition-based stats. Identities = 159/468 (33%), Positives = 246/468 (52%), Gaps = 34/468 (7%) Query: 448 GTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKA 507 G K A ++A E +QIE F + +TL V K +E+E GL K+ + Sbjct: 5 GPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGN-- 62 Query: 508 TVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIM 567 + M+P +V P G E GDFLA+DLGGTN RV+LVK+ G RT + Y +P + M Sbjct: 63 -IPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKL--GGDRTFDTTQSKYRLP-DAM 118 Query: 568 QGT--GDELFDHIVSCISDFLDYMGIKGPR--MPLGFTFSFPCHQTNLDCGILISWTKGF 623 + T DEL++ I + F+D +G +PLGFTFSFP Q ++ GIL WTKGF Sbjct: 119 RTTQNPDELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGF 178 Query: 624 KATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTN 683 + E HDV +L+ + +R ++VVA++NDT GT++ Y +P ++G+I GTG N Sbjct: 179 DIPNIENHDVVPMLQKQITKRN-IPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVN 237 Query: 684 ACYMEEMKNVEMVEGN-------QGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNS 736 Y + ++E ++G M IN E+G+F DN + RT +D +DE S Sbjct: 238 GAYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRP 296 Query: 737 GKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLA 796 G+Q FEKM SG YLGEI+R L+D K+GF+F+ Q + +T + ++IE D Sbjct: 297 GQQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFE 356 Query: 797 LLQVRAILQQ--LGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHL 854 L+ L Q G+N+T + L++ + ++ RAA+L G+AA+ +K + Sbjct: 357 NLEDTDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRG------YK 410 Query: 855 NVTVGVDGTLYKLHPHFSRIMHQTVKELS-------PKCTVSFLLSED 895 + DG++Y +P F +K++ + + +ED Sbjct: 411 TGHIAADGSVYNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAED 458 Score = 550 bits (1418), Expect = e-157, Method: Composition-based stats. Identities = 127/448 (28%), Positives = 232/448 (51%), Gaps = 32/448 (7%) Query: 19 VKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKG 78 +++I+ + + E L + F E++ GLS+ ++ M+P +V P G E G Sbjct: 24 MQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKK---GGNIPMIPGWVMDFPTGKESG 80 Query: 79 DFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENI-VHGSGTQLFDHVADCLGDF 137 DF+A+DLGG++ R++ V++ + + Y P+ + + +L++ +AD L F Sbjct: 81 DFLAIDLGGTNLRVVLVKLGGD--RTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLKAF 138 Query: 138 MEKKKIK--DKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKK 195 ++++ + + +P+GFTFSFP Q+KI+E +L WTK F +E DVV +L K I K Sbjct: 139 IDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITK 198 Query: 196 RGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEG----- 250 R + +VA++NDT GT++ Y D + ++G+I GTG N Y + I+ ++G Sbjct: 199 R-NIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDD 257 Query: 251 --DEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRL 308 M IN E+G+F D+ + RT++D +D S PG+Q FEKM SG Y+GE++RL Sbjct: 258 IPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRL 316 Query: 309 ILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDK-EGIQNAKEILTR-LGVEPSDV 366 L+ M K+G +F+ + + +TS + IE+D E +++ ++ G+ + Sbjct: 317 ALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTVQ 376 Query: 367 DCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRR 426 + ++ + ++ R+A L + AI + G + DGS+Y +P + + Sbjct: 377 ERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTG------HIAADGSVYNRYPGFKEK 430 Query: 427 FHKTLRRLVP-------DSDVRFLLSES 447 L+ + D ++ + +E Sbjct: 431 AANALKDIYGWTQTSLDDYPIKIVPAED 458 >3B8A-X nrPDB Length = 485 Score = 563 bits (1450), Expect = e-160, Method: Composition-based stats. Identities = 159/482 (32%), Positives = 261/482 (54%), Gaps = 33/482 (6%) Query: 448 GTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKA 507 G K A ++A E +I + F + +TL +V K E+ GL K+ + Sbjct: 5 GPKKPQARKGSMADVPKELMDEIHQLEDMFTVDSETLRKVVKHFIDELNKGLTKKGGN-- 62 Query: 508 TVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIM 567 + M+P +V P G E G++LA+DLGGTN RV+LVK+ T + Y +P ++ Sbjct: 63 -IPMIPGWVMEFPTGKESGNYLAIDLGGTNLRVVLVKLSG--NHTFDTTQSKYKLPHDMR 119 Query: 568 QGT-GDELFDHIVSCISDFL---DYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGF 623 +EL+ I + DF+ + + K +PLGFTFS+P Q ++ GIL WTKGF Sbjct: 120 TTKHQEELWSFIADSLKDFMVEQELLNTKD-TLPLGFTFSYPASQNKINEGILQRWTKGF 178 Query: 624 KATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTN 683 + EGHDV LL++ + +RE +++VA++NDTVGT++ Y +P ++G+I GTG N Sbjct: 179 DIPNVEGHDVVPLLQNEISKRE-LPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVN 237 Query: 684 ACYMEEMKNVEMVEGN-------QGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNS 736 + + + ++E +EG M IN E+G+F DN L RT +D VDE S Sbjct: 238 GAFYDVVSDIEKLEGKLADDIPSNSPMAINCEYGSF-DNEHLVLPRTKYDVAVDEQSPRP 296 Query: 737 GKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLA 796 G+Q FEKM SG YLGE++R +L++ +KG + + Q LK I +T + ++IE D Sbjct: 297 GQQAFEKMTSGYYLGELLRLVLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFE 356 Query: 797 LLQVRAILQQ--LGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHL 854 L+ + Q G+ +T + L++ +C ++ RAA+L G+AA+ +K + Sbjct: 357 NLEDTDDIFQKDFGVKTTLPERKLIRRLCELIGTRAARLAVCGIAAICQKRG------YK 410 Query: 855 NVTVGVDGTLYKLHPHFSRIMHQTVKEL------SPKCTVSFLLSEDGSGKGAALITAVG 908 + DG++Y +P F + ++++ + K ++ + +EDGSG GAA+I A+ Sbjct: 411 TGHIAADGSVYNKYPGFKEAAAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIAALS 470 Query: 909 VR 910 + Sbjct: 471 EK 472 Score = 534 bits (1377), Expect = e-152, Method: Composition-based stats. Identities = 143/462 (30%), Positives = 246/462 (53%), Gaps = 31/462 (6%) Query: 19 VKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKG 78 + +I + + E L ++ F E+ GL++ ++ M+P +V P G E G Sbjct: 24 MDEIHQLEDMFTVDSETLRKVVKHFIDELNKGLTKK---GGNIPMIPGWVMEFPTGKESG 80 Query: 79 DFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENI-VHGSGTQLFDHVADCLGDF 137 +++A+DLGG++ R++ V+++ N Y P ++ +L+ +AD L DF Sbjct: 81 NYLAIDLGGTNLRVVLVKLSG--NHTFDTTQSKYKLPHDMRTTKHQEELWSFIADSLKDF 138 Query: 138 MEKKKIKDKK--LPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKK 195 M ++++ + K LP+GFTFS+P Q+KI+E +L WTK F VEG DVV LL I K Sbjct: 139 MVEQELLNTKDTLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEISK 198 Query: 196 RGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGD---- 251 R + IVA++NDTVGT++ Y D + ++G+I GTG N + + + I+ +EG Sbjct: 199 R-ELPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKLADD 257 Query: 252 ---EGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRL 308 M IN E+G+F D+ L RT++D +D S PG+Q FEKM SG Y+GEL+RL Sbjct: 258 IPSNSPMAINCEYGSF-DNEHLVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLRL 316 Query: 309 ILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDK-EGIQNAKEILT-RLGVEPSDV 366 +L+++ ++GL+ + + +L +TS + IE D E +++ +I GV+ + Sbjct: 317 VLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLEDTDDIFQKDFGVKTTLP 376 Query: 367 DCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRR 426 + ++ +C ++ R+A L + AI + G + DGS+Y +P + Sbjct: 377 ERKLIRRLCELIGTRAARLAVCGIAAICQKRGYKTG------HIAADGSVYNKYPGFKEA 430 Query: 427 FHKTLRRL------VPDSDVRFLLSESGTGKGAAMVTAVAYR 462 K LR + + + +E G+G GAA++ A++ + Sbjct: 431 AAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIAALSEK 472 >5ZQT-A nrPDB Length = 473 Score = 551 bits (1420), Expect = e-157, Method: Composition-based stats. Identities = 173/456 (37%), Positives = 246/456 (53%), Gaps = 24/456 (5%) Query: 470 IEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFL 529 IEE F L + + EME GLR + + A +KML S+V ++P G EHG F Sbjct: 16 IEEVEQRFSTPTALLRGIADAMVEEMERGLRADPH--APLKMLISYVDNLPTGDEHGLFY 73 Query: 530 ALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFL--- 586 ALDLGGTNFRV+ V++ +KR V + +IP +M GT ELFD I + + F+ Sbjct: 74 ALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFVKTE 133 Query: 587 --DYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRR 644 D+ +G + LGFTFSFP HQT++ G LI WTKGF G DV + L A++ R Sbjct: 134 GEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME-R 192 Query: 645 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEG---NQG 701 + D+ V A+VNDTVGT+ Y + +I+GTGTNA Y+E + G G Sbjct: 193 QGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRSG 252 Query: 702 QMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDF 761 M INMEWG F R+D+D +D SLN G+Q +EKMISGMYLGEIVR IL+ Sbjct: 253 NMVINMEWGNFKSER---LPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLKL 309 Query: 762 TKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLA-LLQVRAILQQ-LGL-NSTCDDSIL 818 LF + L+ R I T +S + D L + A L+ LG+ +++ + + Sbjct: 310 AHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLEARYI 369 Query: 819 VKTVCGVVSKRAAQLCGAGMAAVVEKIRENR----GLDHLNVTVGVDGTLYKLHPHFSRI 874 VC +V++R A+L AG+ +++K+ +R G + +DG LY+ + F Sbjct: 370 TLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKFRTC 429 Query: 875 MHQTVKEL---SPKCTVSFLLSEDGSGKGAALITAV 907 + T+ +L +V L+ DGSG GAAL+ A Sbjct: 430 LEATLADLLGEEAASSVVVKLANDGSGIGAALLAAS 465 Score = 521 bits (1342), Expect = e-148, Method: Composition-based stats. Identities = 166/459 (36%), Positives = 253/459 (55%), Gaps = 30/459 (6%) Query: 22 IDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFI 81 I++ +L I +EM+ GL D P A +KML ++V ++P G E G F Sbjct: 16 IEEVEQRFSTPTALLRGIADAMVEEMERGLRAD--PHAPLKMLISYVDNLPTGDEHGLFY 73 Query: 82 ALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKK 141 ALDLGG++FR++RVQ+ + + VS + E P +++ G+ +LFD +A L F+ K Sbjct: 74 ALDLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSMELFDFIAAELESFV-KT 132 Query: 142 KIKDKKLP------VGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKK 195 + +D LP +GFTFSFP Q+ I LI WTK F +G G DVV L++A+++ Sbjct: 133 EGEDFHLPEGRQRELGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAMER 192 Query: 196 RGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEG---DE 252 +G D + A+VNDTVGT+ Y D +I+GTGTNA Y+E I G Sbjct: 193 QG-LDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLLPRS 251 Query: 253 GRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVK 312 G M IN EWG F + R+++D LD SLNPG+Q++EKM+SGMY+GE+VR IL+K Sbjct: 252 GNMVINMEWGNFKSER---LPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRILLK 308 Query: 313 MAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTR----LGVEPSDVDC 368 +A + LF + +L R T D+SA+ D + K + + LGV + ++ Sbjct: 309 LAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTS--HDLKHLGAKLKDILGVADTSLEA 366 Query: 369 VSVQ-HICTIVSFRSANLVAATLGAILNRLRDNK----GTPRLRTTVGVDGSLYKMHPQY 423 + H+C +V+ R A L AA + IL +L ++ G+ + RT + +DG LY+ + ++ Sbjct: 367 RYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKKF 426 Query: 424 SRRFHKTLRRLVPD---SDVRFLLSESGTGKGAAMVTAV 459 TL L+ + S V L+ G+G GAA++ A Sbjct: 427 RTCLEATLADLLGEEAASSVVVKLANDGSGIGAALLAAS 465 >4QS9-A nrPDB Length = 474 Score = 528 bits (1361), Expect = e-150, Method: Composition-based stats. Identities = 158/456 (34%), Positives = 238/456 (52%), Gaps = 26/456 (5%) Query: 470 IEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFL 529 ++ L +V + EM GL + SK +KML S+V ++P G E G F Sbjct: 19 LKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSK--LKMLISYVDNLPSGDEKGLFY 76 Query: 530 ALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFL--- 586 ALDLGGTNFRV+ V + ++R V+ + SIP +M G DELF+ I ++ F+ Sbjct: 77 ALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATE 136 Query: 587 --DYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRR 644 D+ +G + LGFTF+FP QT+L G LI WTKGF + G DV L A++R Sbjct: 137 CEDFHLPEGRQRELGFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERV 196 Query: 645 EEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEG---NQG 701 D+ + A+VNDTVGT+ Y P +I+GTGTNA Y+E + G G Sbjct: 197 -GLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSG 255 Query: 702 QMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDF 761 +M INMEWG F + T+FD +D SLN G+Q EK+ISGMYLGEI+R +L+ Sbjct: 256 EMVINMEWGNFRSSH---LPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKM 312 Query: 762 TKKGFLFRGQISEPLKTRGIFETKFLSQIESDR-----LALLQVRAILQQLGLNSTCDDS 816 + F + L+ I T +S + +D + +++ IL+ ++ Sbjct: 313 AEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEV--PTTSLKMR 370 Query: 817 ILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDH--LNVTVGVDGTLYKLHPHFSRI 874 +V ++C +++ R A+L AG+ +++K+ + D + +DG L++ + FS Sbjct: 371 KVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSEC 430 Query: 875 MHQTVKEL---SPKCTVSFLLSEDGSGKGAALITAV 907 M ++KEL +V S DGSG GAAL+ A Sbjct: 431 MESSLKELLGDEASGSVEVTHSNDGSGIGAALLAAS 466 Score = 499 bits (1286), Expect = e-141, Method: Composition-based stats. Identities = 154/455 (33%), Positives = 233/455 (51%), Gaps = 24/455 (5%) Query: 22 IDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFI 81 + + L + EM GL+ D + +KML ++V ++P G EKG F Sbjct: 19 LKAFEEDCATPISKLRQVADAMTVEMHAGLASDG--GSKLKMLISYVDNLPSGDEKGLFY 76 Query: 82 ALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKK 141 ALDLGG++FR++RV + ++ + V E E P +++ G +LF+ +A+ L F+ Sbjct: 77 ALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFV-AT 135 Query: 142 KIKDKKLP------VGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKK 195 + +D LP +GFTF+FP +Q+ + LI WTK F G DVV LNKA+++ Sbjct: 136 ECEDFHLPEGRQRELGFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALER 195 Query: 196 RGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEG---DE 252 G D I A+VNDTVGT+ Y + +I+GTGTNA Y+E I G Sbjct: 196 VG-LDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKS 254 Query: 253 GRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVK 312 G M IN EWG F S TEFD LD SLNPG+Q+ EK++SGMY+GE++R +L+K Sbjct: 255 GEMVINMEWGNF---RSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLK 311 Query: 313 MAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNA--KEILTRLGVEPSDVD-CV 369 MA++ F + +L T +SA+ D +I L V + + Sbjct: 312 MAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRK 371 Query: 370 SVQHICTIVSFRSANLVAATLGAILNRLRD--NKGTPRLRTTVGVDGSLYKMHPQYSRRF 427 V +C I++ R A L AA + IL +L K ++ + +DG L++ + Q+S Sbjct: 372 VVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECM 431 Query: 428 HKTLRRLVPD---SDVRFLLSESGTGKGAAMVTAV 459 +L+ L+ D V S G+G GAA++ A Sbjct: 432 ESSLKELLGDEASGSVEVTHSNDGSGIGAALLAAS 466 >2YHX-A nrPDB Length = 457 Score = 124 bits (311), Expect = 2e-28, Method: Composition-based stats. Identities = 66/415 (15%), Positives = 142/415 (34%), Gaps = 30/415 (7%) Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVH 120 + M+P +V G++ G F+A+ +GG ++ + + + ++ + Sbjct: 44 IPMVPGWVLKQVSGAQAGSFLAIVMGGGDLEVILISLAGRQESSIXASRSLAA--AMSTT 101 Query: 121 GSGTQLFDHVADC-LGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASG 179 + L+ + A + +P+GFTF + + + + F + Sbjct: 102 AIPSDLWGNXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAX 161 Query: 180 VEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYM 239 + ++ + A GD + VA + D+ G + Y D ++G+I G+G NA Y Sbjct: 162 L--XKLISAMXNAXFPAGDXXXS-VADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYW 218 Query: 240 EELRHI-----DLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFE 294 + I G G M I + +F + + L+ S K F Sbjct: 219 CDSTXIGDAADGGXXGGAGXMXICCDQSSFR-KAFPSLPQIXYLXTLNXXSPXAXK-TFX 276 Query: 295 KMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKE-GIQNAK 353 K G+ +R +L+ G NTS + I+K ++ Sbjct: 277 KNSXAKNXGQSLRDVLMXFKXXGQX-HXXXAXSFXAANVENTSYPAKIQKLPHFDLRXXX 335 Query: 354 EILT-RLGVEPSDVDCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGV 412 ++ G+ V+ +++ + LV + AI + + G + Sbjct: 336 DLFXGDQGIAXKTXMKXVVRRXLFLIAAYAFRLVVCXIXAICQKKGYSSG------HIAA 389 Query: 413 DGSLYKMHPQYSRRFHKTLRRLVP-------DSDVRFLLSESGTGKGAAMVTAVA 460 GS + + +S + + + G G + ++ ++A Sbjct: 390 XGSX-RSYSGFSXNSATXNXNIYGWPQSAXXSKPIXITPAIDGXGAASXVIXSIA 443 Score = 122 bits (307), Expect = 6e-28, Method: Composition-based stats. Identities = 68/417 (16%), Positives = 148/417 (35%), Gaps = 34/417 (8%) Query: 509 VKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQ 568 + M+P +V G + G FLA+ +GG + V+L+ + ++ ++ + + M Sbjct: 44 IPMVPGWVLKQVSGAQAGSFLAIVMGGGDLEVILISLAGRQESSIXASRSLAA----AMS 99 Query: 569 GT--GDELFDHIVSC-ISDFLDYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKA 625 T +L+ + + +PLGFTF + + G + F Sbjct: 100 TTAIPSDLWGNXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSL 159 Query: 626 TDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNAC 685 + S + +A + VA + D+ G + Y + ++G+I G+G NA Sbjct: 160 AXLX--KLISAMXNAXFPAGDXXXS-VADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAA 216 Query: 686 YMEEMKNV-----EMVEGNQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQR 740 Y + + G G M I + +F + + ++ S + K Sbjct: 217 YWCDSTXIGDAADGGXXGGAGXMXICCDQSSFR-KAFPSLPQIXYLXTLNXXSPXAXK-T 274 Query: 741 FEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQV 800 F K G+ +R++L+ F G + + T + ++I+ L+ Sbjct: 275 FXKNSXAKNXGQSLRDVLMXFKXXGQX-HXXXAXSFXAANVENTSYPAKIQKLPHFDLRX 333 Query: 801 RAILQ--QLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLNVTV 858 L G+ +V+ +++ A +L + A+ +K + + + Sbjct: 334 XXDLFXGDQGIAXKTXMKXVVRRXLFLIAAYAFRLVVCXIXAICQKKG------YSSGHI 387 Query: 859 GVDGTLYKLHPHFSRIMHQTVKELS-------PKCTVSFLLSEDGSGKGAALITAVG 908 G+ + + FS + + + DG G + +I ++ Sbjct: 388 AAXGSX-RSYSGFSXNSATXNXNIYGWPQSAXXSKPIXITPAIDGXGAASXVIXSIA 443 >1HKG-A nrPDB Length = 457 Score = 122 bits (305), Expect = 1e-27, Method: Composition-based stats. Identities = 66/415 (15%), Positives = 141/415 (33%), Gaps = 30/415 (7%) Query: 61 VKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVH 120 + M+P +V GS+ G F+A+ +GG ++ + + + ++ + Sbjct: 44 IPMVPGWVLKQVXGSQAGSFLAIVMGGGDLEVILIXLAGYQESSIXASRSLAA--SMXTT 101 Query: 121 GSGTQLFDHVADC-LGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASG 179 + L+ + A + +P+GFTF + + + + F + Sbjct: 102 AIPSDLWGNXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAX 161 Query: 180 VEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYM 239 + ++ + A GD VA + D+ G + Y D ++G+I G+G NA Y Sbjct: 162 L--XKLISAMXNAXFPAGDX-XXXVADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYW 218 Query: 240 EELRHI-----DLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFE 294 + I G G M + +F + + L+ S K FE Sbjct: 219 CDSTXIADAADAGXXGGAGXMXVCCXQDSFR-KAFPSLPQIXYXXTLNXXSPXAXK-TFE 276 Query: 295 KMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKE-GIQNAK 353 K G+ +R +L+ K + N+S + I+K ++ Sbjct: 277 KNSXAKNXGQSLRDVLMX-YKXXGQXHXXXAXDFXAANVENSSYPAKIQKLPHFDLRXXX 335 Query: 354 EILT-RLGVEPSDVDCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGV 412 ++ G+ V+ +++ + LV + AI + + G + Sbjct: 336 DLFXGDQGIAXKTXMKXVVRRXLFLIAAYAFRLVVCXIXAICQKKGYSSG------HIAA 389 Query: 413 DGSLYKMHPQYSRRFHKTLRRLVP-------DSDVRFLLSESGTGKGAAMVTAVA 460 GS + + +S + + + G G ++ ++A Sbjct: 390 XGSX-RDYSGFSXNSATXNXNIYGWPQSAXXSKPIXITPAIDGEGAAXXVIXSIA 443 Score = 117 bits (292), Expect = 3e-26, Method: Composition-based stats. Identities = 66/417 (15%), Positives = 148/417 (35%), Gaps = 34/417 (8%) Query: 509 VKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQ 568 + M+P +V G++ G FLA+ +GG + V+L+ + ++ ++ + + M Sbjct: 44 IPMVPGWVLKQVXGSQAGSFLAIVMGGGDLEVILIXLAGYQESSIXASRSLAA----SMX 99 Query: 569 GT--GDELFDHIVSC-ISDFLDYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKA 625 T +L+ + + +PLGFTF + + G + F Sbjct: 100 TTAIPSDLWGNXAXSNAAFSSXEFSSXAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSL 159 Query: 626 TDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNAC 685 + S + +A + VA + D+ G + Y + ++G+I G+G NA Sbjct: 160 AXLX--KLISAMXNAXFPAGDX-XXXVADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAA 216 Query: 686 YMEEMKNV-----EMVEGNQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQR 740 Y + + G G M + +F + + ++ S + K Sbjct: 217 YWCDSTXIADAADAGXXGGAGXMXVCCXQDSFR-KAFPSLPQIXYXXTLNXXSPXAXK-T 274 Query: 741 FEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQV 800 FEK G+ +R++L+ + G + + + + ++I+ L+ Sbjct: 275 FEKNSXAKNXGQSLRDVLMXYKXXGQX-HXXXAXDFXAANVENSSYPAKIQKLPHFDLRX 333 Query: 801 RAILQ--QLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLNVTV 858 L G+ +V+ +++ A +L + A+ +K + + + Sbjct: 334 XXDLFXGDQGIAXKTXMKXVVRRXLFLIAAYAFRLVVCXIXAICQKKG------YSSGHI 387 Query: 859 GVDGTLYKLHPHFSRIMHQTVKELS-------PKCTVSFLLSEDGSGKGAALITAVG 908 G+ + + FS + + + DG G +I ++ Sbjct: 388 AAXGSX-RDYSGFSXNSATXNXNIYGWPQSAXXSKPIXITPAIDGEGAAXXVIXSIA 443 >3ZR5-A nrPDB Length = 656 Score = 34.6 bits (78), Expect = 0.19, Method: Composition-based stats. Identities = 24/129 (18%), Positives = 44/129 (34%), Gaps = 4/129 (3%) Query: 50 GLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQN--VSM 107 G+ A+ ++L + P SE D++ G+S IL+V++ + Sbjct: 29 GIGAVSGGGATSRLLVNYPE--PYRSEILDYLFKPNFGASLHILKVEIGGDGQTTDGTEP 86 Query: 108 ESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAV 167 Y+ EN G L D + +G FS+P ++ Sbjct: 87 SHMHYELDENYFRGYEWWLMKEAKKRNPDIILMGLPWSFPGWLGKGFSWPYVNLQLTAYY 146 Query: 168 LITWTKRFK 176 ++ W K Sbjct: 147 VVRWILGAK 155 >2BWY-A nrPDB Length = 440 Score = 32.7 bits (73), Expect = 0.80, Method: Composition-based stats. Identities = 24/111 (21%), Positives = 44/111 (39%), Gaps = 21/111 (18%) Query: 229 IIGTGTNACYMEELRH-IDLVEGDEGRMCINTEWGAFGDDGSLEDI---------RTEFD 278 I+G+G N C + + ++ +GD + E+ + D + R +D Sbjct: 232 IVGSGENGCILHYTENECEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQREIYD 291 Query: 279 RELD--RGSLN---PGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRI 324 L+ SL PG + E GE+VR+++ + K G+L Sbjct: 292 IVLESLETSLRLYRPGTSILE------VTGEVVRIMVSGLVKLGILKGDVD 336 >4NK4-A nrPDB Length = 301 Score = 31.5 bits (70), Expect = 1.7, Method: Composition-based stats. Identities = 17/80 (21%), Positives = 32/80 (40%), Gaps = 4/80 (5%) Query: 23 DKYLYAMRLSDEILIDILTRFKKEM-KNGLSRDYNPTASVKMLPTFVRSIPDGS---EKG 78 D ++ M +S +I+ R + M G S++++P + P S Sbjct: 145 DNFIQTMLVSCFSFTEIVRRAAQLMPHGGAMITLTYGGSMRVVPNYNAMAPAKSALESST 204 Query: 79 DFIALDLGGSSFRILRVQVN 98 ++A D GG + RI + Sbjct: 205 KYLACDYGGMNIRINAISAG 224 >5ZI1-A nrPDB Length = 609 Score = 30.3 bits (67), Expect = 3.6, Method: Composition-based stats. Identities = 8/42 (19%), Positives = 20/42 (47%) Query: 399 DNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDSDV 440 +G +L+ GV G +++ + ++ R + L+P + Sbjct: 194 YKEGLNKLKNASGVKGKVWENYNRFRREMTIMVLDLLPLFPI 235 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.314 0.141 0.379 Lambda K H 0.267 0.0432 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 35,377,515 Number of Sequences: 36641 Number of extensions: 1523652 Number of successful extensions: 4240 Number of sequences better than 10.0: 18 Number of HSP's better than 10.0 without gapping: 30 Number of HSP's successfully gapped in prelim test: 8 Number of HSP's that attempted gapping in prelim test: 3976 Number of HSP's gapped (non-prelim): 70 length of query: 918 length of database: 10,336,785 effective HSP length: 106 effective length of query: 812 effective length of database: 6,452,839 effective search space: 5239705268 effective search space used: 5239705268 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 64 (29.2 bits)