BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P05546 (499 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1JMJ-A nrPDB 999 0.0 6EE5-A nrPDB 276 1e-74 1BY7-A nrPDB 195 5e-50 5HGC-A nrPDB 194 7e-50 4AJT-A nrPDB 190 1e-48 2VDY-A nrPDB 190 1e-48 6HGE-B nrPDB 183 1e-46 3NE4-A nrPDB 182 3e-46 1YXA-A nrPDB 182 4e-46 4GA7-A nrPDB 181 6e-46 5INW-A nrPDB 181 9e-46 1UHG-A nrPDB 178 6e-45 4EB1-I nrPDB 171 7e-43 4Y40-A nrPDB 170 1e-42 4ZK0-A nrPDB 169 2e-42 3NDA-A nrPDB 169 3e-42 1ATT-A nrPDB 167 1e-41 2OL2-A nrPDB 164 6e-41 1HLE-A nrPDB 158 5e-39 2H4Q-A nrPDB 154 6e-38 2H4P-A nrPDB 154 1e-37 2V95-A nrPDB 153 2e-37 1XQJ-A nrPDB 151 5e-37 4AJU-A nrPDB 150 1e-36 3DY0-A nrPDB 150 2e-36 3F02-A nrPDB 148 5e-36 2R9Y-A nrPDB 147 1e-35 2XN5-A nrPDB 147 1e-35 1QMB-A nrPDB 147 1e-35 4DY0-A nrPDB 147 1e-35 6F02-A nrPDB 145 4e-35 5NCS-A nrPDB 145 5e-35 1C8O-A nrPDB 136 2e-32 1IMV-A nrPDB 135 6e-32 1C5G-A nrPDB 130 1e-30 4P0F-A nrPDB 129 2e-30 3LW2-A nrPDB 129 4e-30 1M93-B nrPDB 128 7e-30 3OZQ-A nrPDB 127 1e-29 6F4U-A nrPDB 125 5e-29 1JJO-C nrPDB 122 3e-28 3ZHA-A nrPDB 122 3e-28 5NCU-A nrPDB 122 5e-28 3LE2-A nrPDB 121 6e-28 4KDS-A nrPDB 118 6e-27 1K9O-I nrPDB 117 1e-26 1SEK-A nrPDB 114 1e-25 6CJ7-A nrPDB 109 3e-24 4DTE-A nrPDB 107 1e-23 3PZF-A nrPDB 102 5e-22 1SNG-A nrPDB 100 2e-21 3STO-A nrPDB 98 1e-20 2OAY-A nrPDB 93 3e-19 2PEF-A nrPDB 81 9e-16 1MTP-A nrPDB 77 2e-14 5M3Y-A nrPDB 70 1e-12 2WXX-A nrPDB 70 3e-12 2WXZ-C nrPDB 68 8e-12 6BJ5-B nrPDB 60 2e-09 5C98-A nrPDB 49 7e-06 1Z1W-A nrPDB 30 2.2 5EUL-Y nrPDB 29 5.5 4RNY-A nrPDB 28 7.7 >1JMJ-A nrPDB Length = 480 Score = 999 bits (2584), Expect = 0.0, Method: Compositional matrix adjust. Identities = 480/480 (100%), Positives = 480/480 (100%) Query: 20 GSKGPLDQLEKGGETAQSADPQWEQLNNKNLSMPLLPADFHKENTVTNDWIPEGEEDDDY 79 GSKGPLDQLEKGGETAQSADPQWEQLNNKNLSMPLLPADFHKENTVTNDWIPEGEEDDDY Sbjct: 1 GSKGPLDQLEKGGETAQSADPQWEQLNNKNLSMPLLPADFHKENTVTNDWIPEGEEDDDY 60 Query: 80 LDLEKIFSEDDDYIDIVDSLSVSPTDSDVSAGNILQLFHGKSRIQRLNILNAKFAFNLYR 139 LDLEKIFSEDDDYIDIVDSLSVSPTDSDVSAGNILQLFHGKSRIQRLNILNAKFAFNLYR Sbjct: 61 LDLEKIFSEDDDYIDIVDSLSVSPTDSDVSAGNILQLFHGKSRIQRLNILNAKFAFNLYR 120 Query: 140 VLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIH 199 VLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIH Sbjct: 121 VLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIH 180 Query: 200 NLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFI 259 NLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFI Sbjct: 181 NLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFI 240 Query: 260 SKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNERE 319 SKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNERE Sbjct: 241 SKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNERE 300 Query: 320 VVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVE 379 VVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVE Sbjct: 301 VVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVE 360 Query: 380 RWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKH 439 RWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKH Sbjct: 361 RWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKH 420 Query: 440 QGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPSRS 499 QGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPSRS Sbjct: 421 QGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPSRS 480 >6EE5-A nrPDB Length = 379 Score = 276 bits (706), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 149/380 (39%), Positives = 218/380 (57%), Gaps = 12/380 (3%) Query: 117 FHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQ 176 F G + +L N FAF+LYR L + + NIF +PV IS+A+ M+SLG KG+TH Q Sbjct: 12 FQGAASSHKLAEANTDFAFSLYRELA-KSSPDKNIFFSPVSISSALAMLSLGAKGDTHTQ 70 Query: 177 VHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDF 236 + L F + IH F+ L L R G L++ N L++ K +L F Sbjct: 71 ILEGLGFNSEAD---------IHQGFQHLLQTLNRPK-GLQLKTANGLFVDKSLKLLDSF 120 Query: 237 KTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFK 296 ++ Y AEA DF + N+ + K T G IKD L+++D T ++++N IYFK Sbjct: 121 LEDSKKLYQAEAFSVDFDPEEAKKQINDWVEKQTNGKIKDLLKDLDSDTVLVLVNAIYFK 180 Query: 297 GSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISML 356 G W F E T +F ++E+ VKV MM KG F +D EL C +L+L Y G SML Sbjct: 181 GKWKKPFDPENTKEEDFHVDEKTTVKVPMMSQKGKFYYYHDDELSCKVLELPYKGNASML 240 Query: 357 IVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRM 416 I++P + G++ LE LTP + +W KS+T R+ E+ LPKFK+E Y+L E L +GI Sbjct: 241 IILPDE-GGLQHLEQSLTPETLSKWLKSLTRRSVELYLPKFKIEGTYDLKEVLSNLGITD 299 Query: 417 LFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFL 476 LF +++GI+++++ + H+ + VNEEGT+A T + +P+S F DRPFL Sbjct: 300 LFSPGADLSGITEEKLYVSKAVHKAVLEVNEEGTEAAAATFLEAIPMSIPPEFKADRPFL 359 Query: 477 FLIYEHRTSCLLFMGRVANP 496 FLI E++T +LFMG+V NP Sbjct: 360 FLIRENKTGSILFMGKVVNP 379 >1BY7-A nrPDB Length = 382 Score = 195 bits (495), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 128/392 (32%), Positives = 209/392 (53%), Gaps = 28/392 (7%) Query: 123 IQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILH 182 ++ L + N FA NL++ L T N+F++P IS+ M M+ +G +G T +Q+ +L Sbjct: 1 MEDLCVANTLFALNLFKHLAKASPT-QNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQ 59 Query: 183 FKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVRE 242 F + A+ K IH+ FR L+ + Y L SVN L+ +K ++ ++ Sbjct: 60 FNEVGAAADK-----IHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQK 114 Query: 243 YYFAEAQIADFSDPAFIS--KTNNHIMKLTKGLIKDALE--NIDPATQMMILNCIYFKGS 298 YY +E Q DF + A + K N+ + TKG I + L ++D T+M+++N +YFKG Sbjct: 115 YYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGK 174 Query: 299 WVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIV 358 W F ++ + FR+N + V MM + ++L IL+L Y G +SM ++ Sbjct: 175 WKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLL 234 Query: 359 VPHKMS----GMKTLEAQLTPRVVERW--QKSMTNRTREVLLPKFKLEKNYNLVESLKLM 412 +P +++ G++ LE+++T + +W + M EV +P+FKLE++Y L L+ M Sbjct: 235 LPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSM 294 Query: 413 GIRMLFDKN-GNMAGISDQRIAIDLFK----HQGTITVNEEGTQATTVTTVGFMPLST-- 465 G+ F+K N +G+S++ DLF HQ + VNEEGT+A T G M T Sbjct: 295 GMEDAFNKGRANFSGMSERN---DLFLSEVFHQAMVDVNEEGTEA-AAGTGGVMTGRTGH 350 Query: 466 -QVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496 +F D PFLFLI T+C+LF GR ++P Sbjct: 351 GGPQFVADHPFLFLIMHKITNCILFFGRFSSP 382 >5HGC-A nrPDB Length = 380 Score = 194 bits (493), Expect = 7e-50, Method: Compositional matrix adjust. Identities = 116/370 (31%), Positives = 186/370 (50%), Gaps = 9/370 (2%) Query: 130 NAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNA 189 NA FAF +R + + NIF +PV ISTA M++LG + T Q+ L F Sbjct: 15 NADFAFQFFREVTQEAPN-KNIFYSPVSISTAFAMLALGARSATQSQILEGLAFN----- 68 Query: 190 SSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQ 249 ++ + IH F L H L G L +N +++ +L F + Y EA Sbjct: 69 LTEIQEKEIHEGFHNLIHMLNHPEGGVQLNMMNAIFVTAALALLRKFLDDAKALYQLEAF 128 Query: 250 IADFSDPAFISK-TNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMT 308 DF+ P K N++I + T G I + ++++DP T M++ + +YFKGSW F E T Sbjct: 129 TTDFNKPTEAEKQINDYIERKTHGKITNLVKDMDPQTVMLLASFVYFKGSWEKPFEAEHT 188 Query: 309 HNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKT 368 F ++ VKV MM G F D+EL C +++L Y G + +V+P K MK Sbjct: 189 EEREFFVDAETTVKVPMMYQMGRFDFYFDEELSCTVVRLHYNGSATAFLVLPAK-GKMKQ 247 Query: 369 LEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGIS 428 LE L +++W + R + PKF + +Y + +L+ MGI +F +++GI+ Sbjct: 248 LEQTLDKETIQKWSDHLFQRFMNLYFPKFSISGSYEISNTLRKMGIVDVFTNQADLSGIT 307 Query: 429 DQR-IAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCL 487 + + H+ ++ V+E+GT+A T V MP+S PFL LI++ T+ Sbjct: 308 GSPDLKVSKVVHKASLDVDEKGTEAAAATAVEIMPISFPPTIEFSHPFLMLIFDRDTNST 367 Query: 488 LFMGRVANPS 497 LF+G++ NP+ Sbjct: 368 LFIGKIVNPT 377 >4AJT-A nrPDB Length = 427 Score = 190 bits (483), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 123/377 (32%), Positives = 193/377 (51%), Gaps = 10/377 (2%) Query: 124 QRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHF 183 Q+L+ + F FNL R K + N+ +P G+S AM + LG KGET Q+ + L+ Sbjct: 56 QQLSNETSSFGFNLLR--KISMRHDGNVIFSPFGLSVAMVNLMLGTKGETKVQIENGLNL 113 Query: 184 KDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREY 243 + A + LF+K+ F N L + +I K F I + ++Y Sbjct: 114 QALSQAGP----LILPALFKKVKET-FSSNRDLGLSQGSFAFIHKDFDIKETYFNLSKKY 168 Query: 244 YFAEAQIADFSDPAFISKTNNH-IMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNK 302 + E +F + + NH I+K T+G I + I+P T++++++ + FKG W+ Sbjct: 169 FDIEYVSINFQNSSQARGLINHCIVKETEGKIPKLFDEINPETKLILVDYVLFKGKWLTP 228 Query: 303 FPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHK 362 F T F L++ +KV MM +GNF + D++ C IL+L Y G +ML+V+ K Sbjct: 229 FDPSFTEADTFHLDKYRAIKVPMMYREGNFTSTFDKKFRCHILKLPYQGNATMLVVLMEK 288 Query: 363 MSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNG 422 LE LT +VE W ++M R EV PKFKL + Y + E LK MGIR LF + Sbjct: 289 TGDYLALEDYLTVDLVETWLQNMKTRKMEVFFPKFKLNQRYEMHELLKQMGIRRLFSTSA 348 Query: 423 NMAGIS--DQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIY 480 +++ +S + + + Q + V+E GT+A + T + S V+RPF F+IY Sbjct: 349 DLSELSAMARNLQVSRVLQQSVLEVDERGTEAVSGTLSEIIAYSMPPAIKVNRPFHFIIY 408 Query: 481 EHRTSCLLFMGRVANPS 497 E + LLF+GRV NP+ Sbjct: 409 EEMSRMLLFLGRVVNPT 425 >2VDY-A nrPDB Length = 373 Score = 190 bits (482), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 119/370 (32%), Positives = 194/370 (52%), Gaps = 11/370 (2%) Query: 130 NAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNA 189 N FAF+LY+ L ++ NIFI+PV IS A+ M+SLG G T Q+ L F N Sbjct: 11 NVDFAFSLYKHLV-ALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGF----NL 65 Query: 190 SSKYEITTIHNLFRKLTHRLF-RRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEA 248 + + E T IH F+ L H+LF + + + N L++ +L F ++ YY +E Sbjct: 66 TERSE-TEIHQGFQHL-HQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEV 123 Query: 249 QIADFSDPAFISK-TNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEM 307 +F D A S+ N+++ T+G I D +D ++++N I+FKG+W F + Sbjct: 124 LAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLAS 183 Query: 308 THNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMK 367 T NF ++E VVKV MM +D EL C ++Q+ YVG ++ ++P K M Sbjct: 184 TREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGNGTVFFILPDK-GKMN 242 Query: 368 TLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGI 427 T+ A L+ + RW +T+ ++ +PK + Y+L + L+ MGI LF N + I Sbjct: 243 TVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTTQANFSRI 302 Query: 428 S-DQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSC 486 + D ++ H+ + +NEEGT+A + +P S + ++PF+ +I++H T Sbjct: 303 TQDAQLKSSKVVHKAVLQLNEEGTEAAGAMFLEAIPRSKPIILRFNQPFIIMIFDHFTWS 362 Query: 487 LLFMGRVANP 496 LF+ RV NP Sbjct: 363 SLFLARVMNP 372 >6HGE-B nrPDB Length = 409 Score = 183 bits (465), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 123/380 (32%), Positives = 199/380 (52%), Gaps = 19/380 (5%) Query: 130 NAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNA 189 N FAF+LY+ L + N+ +P+ ISTA+ +SLG T ++ L F + Sbjct: 39 NVDFAFSLYKQLVLKAPD-KNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFN--LTE 95 Query: 190 SSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQ 249 +S+ EI H F+ L L + + L N +++++Q +L F + Y +EA Sbjct: 96 TSEAEI---HQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAF 152 Query: 250 IADFSDPAFISK-TNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMT 308 DF D A K N+++ T+G I D ++++D T M+++N I+FK W F + T Sbjct: 153 ATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKWEMPFDPQDT 212 Query: 309 HNHNFRLNEREVVKVSMMQTKGNFLAA-NDQELDCDILQLEYVGGISMLIVVPHKMSGMK 367 H F L++++ V V MM + D+EL C ++QL Y G S L ++P + M+ Sbjct: 213 HQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVQLNYTGNASALFILPDQ-DKME 271 Query: 368 TLEAQLTPRVVERWQKSMTNR-TREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAG 426 +EA L+ + RW S+ R E+ LPKF + ++YNL + L +GI F +++G Sbjct: 272 EVEAMLSRETLNRWGDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSG 331 Query: 427 ISDQR-IAIDLFKHQGTITVNEEGTQATTVTTVGFMPLS------TQVRFTVDRPFLFLI 479 I+ R +A+ H+ + V EEGT+A+ T V LS T VRF +RPFL +I Sbjct: 332 ITGARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRF--NRPFLMII 389 Query: 480 YEHRTSCLLFMGRVANPSRS 499 +H T + FM +V NP ++ Sbjct: 390 VDHFTWSIFFMSKVTNPKQA 409 >3NE4-A nrPDB Length = 424 Score = 182 bits (461), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 111/370 (30%), Positives = 204/370 (55%), Gaps = 9/370 (2%) Query: 131 AKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNAS 190 A+FAF+LYR L Q N+ NIF +PV I+TA M+SLG K +TH+++ L+F N + Sbjct: 61 AEFAFSLYRQLAHQSNS-TNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNF----NLT 115 Query: 191 SKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQI 250 E IH F++L L + + L + N L++ + ++ F V++ Y +EA Sbjct: 116 EIPE-AQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFT 174 Query: 251 ADFSDPAFISK-TNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTH 309 +F D K N+++ K T+G I D ++ +D T ++N I+FKG W F V+ T Sbjct: 175 VNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTE 234 Query: 310 NHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTL 369 +F +++ VKV MM+ G F + ++L +L ++Y+G + + +P + ++ L Sbjct: 235 EEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDE-GKLQHL 293 Query: 370 EAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISD 429 E +LT ++ ++ ++ R+ + LPK + Y+L L +GI +F +++G+++ Sbjct: 294 ENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTE 353 Query: 430 QR-IAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLL 488 + + + H+ +T++E+GT+A + +P+S ++PF+FL+ E T L Sbjct: 354 EAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPL 413 Query: 489 FMGRVANPSR 498 FMG+V NP++ Sbjct: 414 FMGKVVNPTQ 423 >1YXA-A nrPDB Length = 398 Score = 182 bits (461), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 129/383 (33%), Positives = 205/383 (53%), Gaps = 24/383 (6%) Query: 126 LNILNAKFAFNLYR--VLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHF 183 L +N FAF+LY+ VLK N NI +P+ IS A+ ++SLG KG T E++ L F Sbjct: 27 LASINTDFAFSLYKELVLK---NPDTNIVFSPLSISAALALVSLGAKGNTLEEILEGLKF 83 Query: 184 KDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREY 243 N + E IH F L RL + + + + L+I+K+ IL +F+ K + Sbjct: 84 ----NLTETSE-ADIHQGFGHLLQRLNQPKDQVQISTGSALFIEKRQQILTEFQEKAKTL 138 Query: 244 YFAEAQIADFSDPAFISK-TNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNK 302 Y AEA ADF P K N+++ K T+G+IK+ + ++D T M+++N IYFK W Sbjct: 139 YQAEAFTADFQQPRQAKKLINDYVRKQTQGMIKELVSDLDKRTLMVLVNYIYFKAKWKVP 198 Query: 303 FPVEMTHNHNFRLNEREVVKVSMMQ----TKGNFLAANDQELDCDILQLEYVGGISMLIV 358 F T F +R V V MM T F D+EL C +++L+Y G S L + Sbjct: 199 FDPLDTFKSEFYCGKRRPVIVPMMSMEDLTTPYF---RDEELSCTVVELKYTGNASALFI 255 Query: 359 VPHKMSGMKTLEAQLTPRVVERWQKSMTNR-TREVLLPKFKLEKNYNLVESLKLMGIRML 417 +P + M+ +EA L P + +W+ S+ R E+ LPKF + +Y+L + L +GIR + Sbjct: 256 LPDQ-GRMQQVEASLQPETLRKWKNSLKPRMIDELHLPKFSISTDYSLEDVLSKLGIREV 314 Query: 418 FDKNGNMAGISDQR-IAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVR-FTV--DR 473 F +++ I+ + + + H+ + V E GT+A T V F+P+S ++ TV +R Sbjct: 315 FSTQADLSAITGTKDLRVSQVVHKAVLDVAETGTEAAAATGVKFVPMSAKLYPLTVYFNR 374 Query: 474 PFLFLIYEHRTSCLLFMGRVANP 496 PFL +I++ T F+ ++ANP Sbjct: 375 PFLIMIFDTETEIAPFIAKIANP 397 >4GA7-A nrPDB Length = 389 Score = 181 bits (459), Expect = 6e-46, Method: Compositional matrix adjust. Identities = 125/391 (31%), Positives = 203/391 (51%), Gaps = 25/391 (6%) Query: 121 SRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSI 180 S +++L+ N +FA +L+ L + N NIFI+P IS+AM M+ LG +G T Q+ Sbjct: 9 SGMEQLSSANTRFALDLFLALSEN-NPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKT 67 Query: 181 LHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKV 240 HF + +H+ F+ L + +R Y L+ N LY +K + L +F Sbjct: 68 FHFNT---------VEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVST 118 Query: 241 REYYFAEAQIADFSDPAFISKT--NNHIMKLTKGLIKDALEN--IDPATQMMILNCIYFK 296 ++ Y A+ DF + ++ N + T+G I + L + +D T+++++N IYFK Sbjct: 119 QKTYGADLASVDFQHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFK 178 Query: 297 GSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-GISM 355 G+W +KF E T N FRLN+++ V MM K F ++L C +L+L Y G +SM Sbjct: 179 GNWKDKFMKEATTNAPFRLNKKDRKTVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSM 238 Query: 356 LIVVPHKM----SGMKTLEAQLTPRVVERWQKSMTNRTRE--VLLPKFKLEKNYNLVESL 409 +I++P + +G+K +E QLT + W K E V LP+FKLE++Y L L Sbjct: 239 VILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDL 298 Query: 410 KLMGIRMLFDKN-GNMAGISDQR-IAIDLFKHQGTITVN--EEGTQATTVTTVGFMPLST 465 +G++ LF+ + +++G+S R I I H+ + VN A T F Sbjct: 299 ARLGVQDLFNSSKADLSGMSGARDIFISKIVHKSFVEVNEEGTEAAAATAGIATFCMDDP 358 Query: 466 QVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496 + FT D PFLF I + + +LF+GR ++P Sbjct: 359 EENFTADHPFLFFIRHNSSGSILFLGRFSSP 389 >5INW-A nrPDB Length = 421 Score = 181 bits (458), Expect = 9e-46, Method: Compositional matrix adjust. Identities = 101/342 (29%), Positives = 177/342 (51%), Gaps = 7/342 (2%) Query: 124 QRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHF 183 QR+ F LY+ + DNIF +P+ I++A+G+++ G G T ++ + L F Sbjct: 79 QRIASAVNGLGFRLYKQVLGGAGPADNIFFSPLSIASALGVVTAGANGSTRAELDTALGF 138 Query: 184 KDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREY 243 K+F++ K + F +L L++R+ G+ L N ++ +K + F V Sbjct: 139 KEFLHGKKKAKSM---KYFARLNGALYKRSAGFELMGKNVVFSKKGLWLYRQFTRTVAHL 195 Query: 244 YFAEAQIADFSDPA-FISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNK 302 + + + DF D + N +I K+T D + ++D T ++I+N IYFKGSW NK Sbjct: 196 FKSNVRSVDFGDSKNAVELMNAYIEKVTSKKFPDVISDVDTDTSLVIVNVIYFKGSWGNK 255 Query: 303 FPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHK 362 F ++T N F +N + V M + D++L +++L Y GG SML++VPH+ Sbjct: 256 FEPDLTKNVRFWVNSSYSMMVPTMHQRAKLSYTQDRKLRSTVVKLPYEGGASMLVIVPHR 315 Query: 363 MSGMKTLEAQLTPRVVERWQKSM--TNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDK 420 + +E ++ +E W + +N ++ LPKFK+ +Y+L L MG+ +F Sbjct: 316 TEDLPKVEESVSQEQLEEWLSLLGPSNHYVQLSLPKFKISVSYDLKAYLSAMGMSSMFSY 375 Query: 421 NGNMAGISD-QRIAIDLFKHQGTITVNEEGTQATTVTTVGFM 461 +++ I+ Q++ +D H+ + VNEEGT+A T VG M Sbjct: 376 GADLSRITGMQKLHVDKITHKSVLHVNEEGTEAKAETVVGIM 417 >1UHG-A nrPDB Length = 385 Score = 178 bits (451), Expect = 6e-45, Method: Compositional matrix adjust. Identities = 113/379 (29%), Positives = 192/379 (50%), Gaps = 16/379 (4%) Query: 132 KFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFK------D 185 +F F++++ LK + +NIF P+ I +A+ M+ LG K T Q++ ++ F D Sbjct: 9 EFCFDVFKELKVH-HANENIFYCPIAIMSALAMVYLGAKDSTRTQINKVVRFDKLPGFGD 67 Query: 186 FVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYF 245 + A + +H+ R + +++ + N Y+ + LY ++++PIL ++ V+E Y Sbjct: 68 SIEAQCGTSVN-VHSSLRDILNQITKPNDVYSFSLASRLYAEERYPILPEYLQCVKELYR 126 Query: 246 AEAQIADFSDPAFISK--TNNHIMKLTKGLIKDALE--NIDPATQMMILNCIYFKGSWVN 301 + +F A ++ N+ + T G+I++ L+ ++D T M+++N I FKG W Sbjct: 127 GGLEPINFQTAADQARELINSWVESQTNGIIRNVLQPSSVDSQTAMVLVNAIVFKGLWEK 186 Query: 302 KFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGG-ISMLIVVP 360 F E T FR+ E+E V MM G F A+ IL+L + G +SML+++P Sbjct: 187 AFKDEDTQAMPFRVTEQESKPVQMMYQIGLFRVASMASEKMKILELPFASGTMSMLVLLP 246 Query: 361 HKMSGMKTLEAQLTPRVVERWQKS--MTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLF 418 ++SG++ LE+ + + W S M R +V LP+ K+E+ YNL L MGI +F Sbjct: 247 DEVSGLEQLESIINFEKLTEWTSSNVMEERKIKVYLPRMKMEEKYNLTSVLMAMGITDVF 306 Query: 419 DKNGNMAGISD-QRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLF 477 + N++GIS + + I H +NE G + G S F D PFLF Sbjct: 307 SSSANLSGISSAESLKISQAVHAAHAEINEAGREVVGSAEAGVDAASVSEEFRADHPFLF 366 Query: 478 LIYEHRTSCLLFMGRVANP 496 I T+ +LF GR +P Sbjct: 367 CIKHIATNAVLFFGRCVSP 385 >4EB1-I nrPDB Length = 440 Score = 171 bits (433), Expect = 7e-43, Method: Compositional matrix adjust. Identities = 127/398 (31%), Positives = 191/398 (47%), Gaps = 28/398 (7%) Query: 122 RIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSIL 181 R+ L+ N++FA Y+ L D N DNIF++P+ ISTA M LG +T +Q+ + Sbjct: 47 RVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVF 106 Query: 182 HFKDFVNASSKYEITTIHNLFRKLTHRLFRR-NFGYTLRSVNDLYIQKQFPILLDFKTKV 240 F +S IH F KL RL+R+ N L S N L+ K ++ Sbjct: 107 KFDTISEKTSD----QIHFFFAKLNCRLYRKANKASKLVSANRLFGDKSLTFNETYQDIS 162 Query: 241 REYYFAEAQIADFSDPAFISKT--NNHIMKLTKGLIKD----------ALENIDPATQMM 288 Y A+ Q DF + A S+ N + T+G I D L N +T ++ Sbjct: 163 ELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINVLVLVNTRTSTVLV 222 Query: 289 ILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLE 348 ++N IYFKG W +KF E T F + E SMM +G F E +L+L Sbjct: 223 LVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAE-GTQVLELP 281 Query: 349 YVG-GISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVE 407 + G I+M++++P + +E +LTP V++ W + V +P+F++E ++L E Sbjct: 282 FKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKE 341 Query: 408 SLKLMGIRMLFD-KNGNMAGI----SDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMP 462 L+ MG+ LF + + GI D D F H+ + VNEEG++A T V Sbjct: 342 QLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAF-HKAFLEVNEEGSEAAASTAVVIAG 400 Query: 463 LS---TQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPS 497 S +V F +RPFL I E + ++FMGRVANP Sbjct: 401 RSLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPC 438 >4Y40-A nrPDB Length = 414 Score = 170 bits (431), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 97/353 (27%), Positives = 179/353 (50%), Gaps = 10/353 (2%) Query: 146 NTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKL 205 N NIF++P+ ISTA M+ LG + T +++ +F+ K +H F + Sbjct: 67 NPGRNIFLSPLSISTAFSMLCLGAQDSTLDEIKQGFNFR-------KMPEKDLHEGFHYI 119 Query: 206 THRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKT-NN 264 H L ++ L N L+I ++ F + +Y AE + +F + K N+ Sbjct: 120 IHELTQKTQDLKLSIGNTLFIDQRLQPQRKFLEDAKNFYSAETILTNFQNLEMAQKQIND 179 Query: 265 HIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVS 324 I + T G I + +ENIDP T M++ N I+F+ W ++F +T +F L + VKV Sbjct: 180 FISQKTHGKINNLIENIDPGTVMLLANYIFFRARWKHEFDPNVTKEEDFFLEKNSSVKVP 239 Query: 325 MMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKS 384 MM G + D +L C IL++ Y I+ + ++P + +K LE L RW+ Sbjct: 240 MMFRSGIYQVGYDDKLSCTILEIPYQKNITAIFILPDE-GKLKHLEKGLQVDTFSRWKTL 298 Query: 385 MTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQR-IAIDLFKHQGTI 443 ++ R V +P+ + ++L ++L +G+ +F+++G++ I+ R + + H+ + Sbjct: 299 LSRRVVCVSVPRLHMTGTFDLKKTLSYIGVSKIFEEHGDLTKIAPHRSLKVGEAVHKAEL 358 Query: 444 TVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496 ++E GT+ T +P+ T + +D+P+L LIY + +LF+G++ NP Sbjct: 359 KMDERGTEGAAGTGAQTLPMETPLCVKIDKPYLLLIYSEKIPSVLFLGKIVNP 411 >4ZK0-A nrPDB Length = 390 Score = 169 bits (428), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 109/392 (27%), Positives = 211/392 (53%), Gaps = 20/392 (5%) Query: 123 IQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILH 182 + L+ N KF F+L++ + +NIF +P+ I++A+GM+ LG K T +Q+ +LH Sbjct: 1 MNSLSEANTKFMFDLFQQFRKSKE--NNIFYSPISITSALGMVLLGAKDNTAQQIKKVLH 58 Query: 183 F----KDFVNASSKYEIT---TIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLD 235 F ++ ++ Y + +H+ F+KL + Y L+ N L+ +K + L + Sbjct: 59 FDQVTENTTGKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQE 118 Query: 236 FKTKVREYYFAEAQIADFSDPAFIS--KTNNHIMKLTKGLIKDALE--NIDPATQMMILN 291 + ++++Y + DF++ S K N+ + T IK+ + NI T ++++N Sbjct: 119 YLDAIKKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVN 178 Query: 292 CIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG 351 IYFKG W KF E T F N+ + MM+ +F A+ +++ +L++ Y G Sbjct: 179 AIYFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTSFHFASLEDVQAKVLEIPYKG 238 Query: 352 -GISMLIVVPHKMSGMKTLEAQLTPRVVERWQ--KSMTNRTREVLLPKFKLEKNYNLVES 408 +SM++++P+++ G++ LE +LT + W ++M ++ LP+FK+E++Y+L ++ Sbjct: 239 KDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDT 298 Query: 409 LKLMGIRMLFDKNGNMAGISDQR-IAIDLFKHQGTI---TVNEEGTQATTVTTVGFMPLS 464 L+ MG+ +F+ + +++G++ R + + H+ + E AT V G P S Sbjct: 299 LRTMGMVDIFNGDADLSGMTGSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFGSSPTS 358 Query: 465 TQVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496 T F + PFLF I +++T+ +LF GR ++P Sbjct: 359 TNEEFHCNHPFLFFIRQNKTNSILFYGRFSSP 390 >3NDA-A nrPDB Length = 377 Score = 169 bits (427), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 117/377 (31%), Positives = 186/377 (49%), Gaps = 16/377 (4%) Query: 125 RLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFK 184 +L N +F L R L N+F +P +STAMGM G +G+T +++ L F Sbjct: 6 KLTKANNRFGLRLLRALPSGPE--KNVFFSPYSVSTAMGMAFAGARGQTQQELSQGLGFS 63 Query: 185 DF-VNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREY 243 D + + + T H T RL TL N IQ+ +L +++ ++ Sbjct: 64 DVDLTDAGVLDAYTHH------TERLKSTPSNSTLDVANAAAIQRTLALLNSYESALQSS 117 Query: 244 YFAEAQIADFS-DP-AFISKTNNHIMKLTKGLIKDAL-ENIDPATQMMILNCIYFKGSWV 300 + AE DF+ +P A + NN + + T I+ E +DP T +++LN IYFKG W Sbjct: 118 FGAELHKVDFAGEPQAAVDFVNNWVKRKTHDKIEKLFNEPLDPDTLLVLLNAIYFKGEWN 177 Query: 301 NKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-GISMLIVV 359 F E T F V+V M+ + +L ++++L Y G +M I++ Sbjct: 178 TAFVKEHTEKRQFFNGGVTPVEVDTMRLEARIKYRFFDDLQVEVVELPYRGLDYTMAILL 237 Query: 360 PHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFD 419 P + +G++ L+ LT + + + R VLLPKFKLE Y+L L+ +GI+ +F+ Sbjct: 238 PKENTGVEGLKQNLTIDRFQNYLSDLRERKITVLLPKFKLETKYSLKAPLQSLGIKQIFE 297 Query: 420 KNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLS---TQVRFTVDRPFL 476 +++GI+D + + +H+ + VNEEGT A T V +P S V F VD PFL Sbjct: 298 SGADLSGINDGSLRVSAVEHKAVVEVNEEGTVAAATTGVVIVPYSLGPEPVVFRVDHPFL 357 Query: 477 FLIYEHRTSCLLFMGRV 493 F I RT + F+G+V Sbjct: 358 FFIRNTRTDDIFFVGQV 374 >1ATT-A nrPDB Length = 429 Score = 167 bits (423), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 127/391 (32%), Positives = 195/391 (49%), Gaps = 22/391 (5%) Query: 122 RIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSIL 181 R+ L+ N+ FA Y+ L D N DNIF++P+ ISTA M LG T Q+ + Sbjct: 44 RVWELSKANSHFATAFYQHLADSKNNNDNIFLSPLSISTAFAMTKLGACNNTLTQLMEVF 103 Query: 182 HFKDFVNASSKYEITTIHNLFRKLTHRLFRR-NFGYTLRSVNDLYIQKQFPILLDFKTKV 240 F +S IH F KL RL+R+ N L S N L+ K ++ Sbjct: 104 KFDTISEKTSD----QIHFFFAKLNCRLYRKANKSSELVSANRLFGDKSITFNETYQDIS 159 Query: 241 REYYFAEAQIADFSDPAFISK--TNNHIMKLTKGLIKDAL--ENIDPATQMMILNCIYFK 296 Y A+ Q DF A S+ N I T+G I D + + I+ T ++++N IYFK Sbjct: 160 EVVYGAKLQPLDFKGNAEQSRLTINQWISNKTEGRITDVIPPQAINEFTVLVLVNTIYFK 219 Query: 297 GSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-GISM 355 G W +KF E T F + E V MM + F E +L+L + G I+M Sbjct: 220 GLWKSKFSPENTRKELFYKADGESCSVLMMYQESKFRYRRVAE-STQVLELPFKGDDITM 278 Query: 356 LIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIR 415 ++++P + +E +LTP +++ W +T V +P+F++E ++++ E L+ MG+ Sbjct: 279 VLILPKLEKTLAKVEQELTPDMLQEWLDELTETLLVVHMPRFRIEDSFSVKEQLQDMGLE 338 Query: 416 MLFD-KNGNMAGI-----SDQRIAIDLFKHQGTITVNEEGTQA---TTVTTVGFMPLSTQ 466 LF + + GI SD ++ D F H+ + VNEEG++A T ++ G S + Sbjct: 339 DLFSPEKSRLPGIVAEGRSDLYVS-DAF-HKAFLEVNEEGSEAAASTVISIAGRSLNSDR 396 Query: 467 VRFTVDRPFLFLIYEHRTSCLLFMGRVANPS 497 V F +RPFL LI E + ++FMGRVANP Sbjct: 397 VTFKANRPFLVLIREVALNTIIFMGRVANPC 427 >2OL2-A nrPDB Length = 395 Score = 164 bits (416), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 109/369 (29%), Positives = 186/369 (50%), Gaps = 15/369 (4%) Query: 133 FAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSK 192 F F+LYR L + NIF +PV IS ++ M+SLG T Q+ L + SS+ Sbjct: 37 FTFDLYRALASAAPS-QNIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLN--LQKSSE 93 Query: 193 YEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIAD 252 E+ H F++L L + G+ L N L+ + F + ++ Y A+ + Sbjct: 94 KEL---HRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTN 150 Query: 253 FSDPA-FISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNH 311 F D A + + N+++ K TKG I D L+N+D ++++N I+FK W F + T Sbjct: 151 FRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQ 210 Query: 312 NFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEA 371 +F + VV+V MM + + D+ L C ++ + Y G + L ++P + M+ +E Sbjct: 211 DFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSE-GKMQQVEN 269 Query: 372 QLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQR 431 L+ + + +W K R E+ LPKF +E +Y L + L +GI +F + +++GIS+ Sbjct: 270 GLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHS 329 Query: 432 -IAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQV---RFTVDRPFLFLIYEHRTSCL 487 I + H+ + V+E GT+A T F S ++ R +RPFL I ++ + Sbjct: 330 NIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNN---I 386 Query: 488 LFMGRVANP 496 LF+G+V P Sbjct: 387 LFLGKVNRP 395 >1HLE-A nrPDB Length = 345 Score = 158 bits (399), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 111/327 (33%), Positives = 175/327 (53%), Gaps = 25/327 (7%) Query: 123 IQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILH 182 +++L+ N FA +L+R L + T NIFI+P+ IS+A+ MI LG +G T QV L+ Sbjct: 2 MEQLSTANTHFAVDLFRALNESDPT-GNIFISPLSISSALAMIFLGTRGNTAAQVSKALY 60 Query: 183 FKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVRE 242 F + IH+ F+ L + + Y L+ N LY +K + L DF ++ Sbjct: 61 FD---------TVEDIHSRFQSLNADINKPGAPYILKLANRLYGEKTYNFLADFLASTQK 111 Query: 243 YYFAEAQIADFSD-PAFISKTNNHIMK-LTKGLIKDALEN--IDPATQMMILNCIYFKGS 298 Y AE DF P K N +K T+G I + L +D T+++++N IYFKG+ Sbjct: 112 MYGAELASVDFQQAPEDARKEINEWVKGQTEGKIPELLVKGMVDNMTKLVLVNAIYFKGN 171 Query: 299 WVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGG-ISMLI 357 W KF E T + FRLN+++ V MM K F ++L C +L+L Y G +SM+I Sbjct: 172 WQQKFMKEATRDAPFRLNKKDTKTVKMMYQKKKFPYNYIEDLKCRVLELPYQGKELSMII 231 Query: 358 VVPHKM----SGMKTLEAQLTPRVVERWQKSMTNRTRE--VLLPKFKLEKNYNLVESLKL 411 ++P + +G++ +E QLT + W K E V LP+FKLE++Y+L L Sbjct: 232 LLPDDIEDESTGLEKIEKQLTLDKLREWTKPENLYLAEVNVHLPRFKLEESYDLTSHLAR 291 Query: 412 MGIRMLFDKN-GNMAGISDQRIAIDLF 437 +G++ LF++ +++G+S R DLF Sbjct: 292 LGVQDLFNRGKADLSGMSGAR---DLF 315 >2H4Q-A nrPDB Length = 382 Score = 154 bits (390), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 103/338 (30%), Positives = 178/338 (52%), Gaps = 22/338 (6%) Query: 133 FAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSK 192 F +L+ L ++ N NIF +P IS+A+ + L KG T ++ +LHF+ N Sbjct: 52 FTVDLFNKL-NETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFEQAEN---- 106 Query: 193 YEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIAD 252 IH+ F++L + Y+LRS N +Y++K + +L + ++YY AE Q + Sbjct: 107 -----IHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTYLQLSKKYYKAEPQKVN 161 Query: 253 FSDPAFISKT--NNHIMKLTKGLIKDAL--ENIDPATQMMILNCIYFKGSWVNKFPVEMT 308 F S+ N + K T+ IK+ L +++ T+++++N IYFK W KF E T Sbjct: 162 FKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILVNAIYFKAEWEVKFQAEKT 221 Query: 309 HNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-GISMLIVVPHKM---- 363 FRL++ + V MM + F ++++ +++L YV +SM I++P + Sbjct: 222 SIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPYVKRELSMFILLPDDIKDGT 281 Query: 364 SGMKTLEAQLTPRVVERW--QKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKN 421 +G++ LE +LT + W K MT ++ LPKF LE +L ++L+ MG+ F N Sbjct: 282 TGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDRIDLRDTLRNMGMTTAFTTN 341 Query: 422 GNMAGISDQR-IAIDLFKHQGTITVNEEGTQATTVTTV 458 + G++D++ +AI HQ + V+E+GT+A T V Sbjct: 342 ADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAVAATAV 379 >2H4P-A nrPDB Length = 394 Score = 154 bits (388), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 105/357 (29%), Positives = 181/357 (50%), Gaps = 32/357 (8%) Query: 133 FAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSK 192 F +L+ L ++ N NIF +P IS+A+ + L KG T ++ +LHF + V A S Sbjct: 36 FTVDLFNKL-NETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESS 94 Query: 193 Y-------------------EITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPIL 233 + IH+ F++L + Y+LRS N +Y++K + +L Sbjct: 95 SVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALL 154 Query: 234 LDFKTKVREYYFAEAQIADFSDPAFISKT--NNHIMKLTKGLIKDAL--ENIDPATQMMI 289 + ++YY AE Q +F S+ N + K T+ IK+ L +++ T++++ Sbjct: 155 PTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLIL 214 Query: 290 LNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEY 349 +N IYFK W KF E T FRL++ + V MM + F ++++ +++L Y Sbjct: 215 VNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPY 274 Query: 350 VG-GISMLIVVPHKM----SGMKTLEAQLTPRVVERW--QKSMTNRTREVLLPKFKLEKN 402 V +SM I++P + +G++ LE +LT + W K MT ++ LPKF LE Sbjct: 275 VKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDR 334 Query: 403 YNLVESLKLMGIRMLFDKNGNMAGISDQR-IAIDLFKHQGTITVNEEGTQATTVTTV 458 +L ++L+ MG+ F N + G++D++ +AI HQ + V+E+GT+A T V Sbjct: 335 IDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAV 391 >2V95-A nrPDB Length = 371 Score = 153 bits (386), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 105/381 (27%), Positives = 179/381 (46%), Gaps = 12/381 (3%) Query: 119 GKSRIQR-LNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQV 177 G S R L N FAFNLY+ L +N N I+PV IS A+ M+SLG Q Sbjct: 1 GSSNSHRGLAPTNVDFAFNLYQRLV-ALNPDKNTLISPVSISMALAMVSLG-----SAQT 54 Query: 178 HSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFK 237 S+ + +S+ EI H F+ L + L + + G + N +++ ++ + F Sbjct: 55 QSLQSLGFNLTETSEAEI---HQSFQYLNYLLKQSDTGLEMNMGNAMFLLQKLKLKDSFL 111 Query: 238 TKVREYYFAEAQIADFSDPAFISK-TNNHIMKLTKGLIKDALENIDPATQMMILNCIYFK 296 V++YY +EA DF D S+ N H+ T+G I+ ++D +++N I+ + Sbjct: 112 ADVKQYYESEALAIDFEDWTKASQQINQHVKDKTQGKIEHVFSDLDSPASFILVNYIFLR 171 Query: 297 GSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISML 356 G W F E T +F +NE VKV MM G+ D C ++Q++YVG + Sbjct: 172 GIWELPFSPENTREEDFYVNETSTVKVPMMVQSGSIGYFRDSVFPCQLIQMDYVGNGTAF 231 Query: 357 IVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRM 416 ++P + M T+ A L+ ++RW K MT R + +PKF + Y+L + L+ + I+ Sbjct: 232 FILPDQ-GQMDTVIAALSRDTIDRWGKLMTPRQVNLYIPKFSMSDTYDLKDVLEDLNIKD 290 Query: 417 LFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFL 476 L + +G + H+ + ++E + S + ++PF+ Sbjct: 291 LLTNQSDFSGNTKDVPLTLTMVHKAMLQLDEGNVLPNSTNGAPLHLRSEPLDIKFNKPFI 350 Query: 477 FLIYEHRTSCLLFMGRVANPS 497 L+++ T L M +V NP+ Sbjct: 351 LLLFDKFTWSSLMMSQVVNPA 371 >1XQJ-A nrPDB Length = 389 Score = 151 bits (382), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 95/384 (24%), Positives = 200/384 (52%), Gaps = 25/384 (6%) Query: 126 LNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKD 185 L + N+ FA +L++ L ++ N+ +P+ +ST++ + +G KG+T ++ +LHF++ Sbjct: 18 LQLANSAFAVDLFKQLSEK-EPLGNVLFSPIALSTSLSLAQVGAKGDTANEIGQVLHFEN 76 Query: 186 FVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYF 245 + + F+ +T + + + Y+L+ + LY+ K + +F + + Y Sbjct: 77 ---------VKDVPFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYA 127 Query: 246 AEAQIADFSDPAFISK--TNNHIMKLTKGLIKDALEN--IDPATQMMILNCIYFKGSWVN 301 E + DF D +K NN I LT G ++ L + ++ T+++++N YF G W+ Sbjct: 128 KELETVDFKDKLEETKGQINNSIKDLTDGHFENILADNSVNDQTKILVVNAAYFVGKWMK 187 Query: 302 KFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGG-ISMLIVVP 360 KF T FR+N+ + V MM + F N ++ I++L + +SM I++P Sbjct: 188 KFSESETKESPFRVNKTDTKPVQMMNMEATFSMGNIDSINSKIIELPFQNKHLSMFILLP 247 Query: 361 HKM----SGMKTLEAQLTPRVVERWQ--KSMTNRTREVLLPKFKLEKNYNLVESLKLMGI 414 + +G++ +E QL + +W +M N ++ +PKFK+EK + SL+ +G+ Sbjct: 248 KDVEDESTGLEKIEKQLNSESLSQWTNPSTMANAKVKLSIPKFKVEKMIDPKASLENLGL 307 Query: 415 RMLFDKN-GNMAGISDQR-IAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVD 472 + +F ++ + +G+S+ + +A+ H+ ++ + E+G + V G L + D Sbjct: 308 KHIFSEDTSDFSGMSETKGVALSNVIHKVSLEITEDGGDSIEVP--GARILQHKDELNAD 365 Query: 473 RPFLFLIYEHRTSCLLFMGRVANP 496 PF+++I ++T ++F G+ ++P Sbjct: 366 HPFIYIIRHNKTRNIIFFGKFSSP 389 >4AJU-A nrPDB Length = 387 Score = 150 bits (380), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 102/332 (30%), Positives = 164/332 (49%), Gaps = 10/332 (3%) Query: 124 QRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHF 183 Q+L + F F+L R K + N+ +P G+S AM + LG G T Q+ LH Sbjct: 52 QQLAKETSNFGFSLLR--KISMRHDGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLH- 108 Query: 184 KDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREY 243 + A + + +LF+ L L RN L + +I K F + F + Y Sbjct: 109 ---LQALKPTKPGLLPSLFKGLRETL-SRNLELGLTQGSFAFIHKDFDVKETFFNLSKRY 164 Query: 244 YFAEAQIADFSDPAFISKTNNH-IMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNK 302 + E +F + + + NH I K T+G I + I+P T++++++ I FKG W+ Sbjct: 165 FDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKGKWLTP 224 Query: 303 FPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHK 362 F T F L++ + +KV MM G F + D+ C +L+L Y G +ML+V+ K Sbjct: 225 FDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLVVLMEK 284 Query: 363 MSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNG 422 M LE LT +VE W ++M R EV PKFKL++ Y + E L+ MGIR +F Sbjct: 285 MGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFSPFA 344 Query: 423 NMAGIS--DQRIAIDLFKHQGTITVNEEGTQA 452 +++ +S + + + + I V+E GT+A Sbjct: 345 DLSELSATGRNLQVSRVLQRTVIEVDERGTEA 376 >3DY0-A nrPDB Length = 336 Score = 150 bits (378), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 97/330 (29%), Positives = 166/330 (50%), Gaps = 9/330 (2%) Query: 133 FAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSK 192 F F+LYR L + NIF +PV IS ++ M+SLG T Q+ L + SS+ Sbjct: 12 FTFDLYRALASAAPS-QNIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLN--LQKSSE 68 Query: 193 YEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIAD 252 E+ H F++L L + G+ L N L+ + F + ++ Y A+ + Sbjct: 69 KEL---HRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTN 125 Query: 253 FSDPA-FISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNH 311 F D A + + N+++ K TKG I D L+N+D ++++N I+FK W F + T Sbjct: 126 FRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQ 185 Query: 312 NFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEA 371 +F + VV+V MM + + D+ L C ++ + Y G + L ++P + M+ +E Sbjct: 186 DFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSE-GKMQQVEN 244 Query: 372 QLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQR 431 L+ + + +W K R E+ LPKF +E +Y L + L +GI +F + +++GIS+ Sbjct: 245 GLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHS 304 Query: 432 -IAIDLFKHQGTITVNEEGTQATTVTTVGF 460 I + H+ + V+E GT+A T F Sbjct: 305 NIQVSEMVHKAVVEVDESGTRAAAATGTIF 334 >3F02-A nrPDB Length = 359 Score = 148 bits (374), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 93/337 (27%), Positives = 175/337 (51%), Gaps = 19/337 (5%) Query: 131 AKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNAS 190 A + N+Y L+ +NI +P+ I+ AMGM+ LG +G T +++ + + N Sbjct: 24 ADLSVNMYNRLR-ATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLKNGE 82 Query: 191 SKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQI 250 + ++ ++ + + Y ++ N L++Q F + +F +++Y+ A Sbjct: 83 E-------FSFLKEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAAVNH 135 Query: 251 ADFS-DPAFISKTNNHIMKLTKGLIKDALE--NIDPATQMMILNCIYFKGSWVNKFPVEM 307 DFS + A + N + T L+KD + + D AT + ++N +YFKG+W ++F E Sbjct: 136 VDFSQNVAVANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFRPEN 195 Query: 308 THNHNFRLNEREVVKVSMMQTKGNFL------AANDQELDCDILQLEYVGG-ISMLIVVP 360 T +F ++ V++ MM +G F +N+ +L++ Y G ISM++V+ Sbjct: 196 TRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVLS 255 Query: 361 HKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDK 420 + + TLE + ++VE W S+ + EV LP+F +E+ +L + LK +GI +F K Sbjct: 256 RQEVPLATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEIFIK 315 Query: 421 NGNMAGISDQR-IAIDLFKHQGTITVNEEGTQATTVT 456 + N+ G+SD + I + H+ + VNEEG++A V+ Sbjct: 316 DANLTGLSDNKEIFLSKAIHKSFLEVNEEGSEAAAVS 352 >2R9Y-A nrPDB Length = 430 Score = 147 bits (371), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 110/384 (28%), Positives = 190/384 (49%), Gaps = 32/384 (8%) Query: 124 QRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHF 183 +RL F +L+ ++ Q +T N+ ++P+ ++ A+ ++LG + +T +H +LH Sbjct: 19 RRLAQAMMAFTTDLFSLVA-QTSTSSNLVLSPLSVALALSHLALGAQNQTLHSLHRVLH- 76 Query: 184 KDFVNASSKYEITTIHNLFRKLTHRLFRRNFGY-TLRSVNDLYIQKQFPILLDFKTKVRE 242 + T L L+H F +N G T+R +Y+QK FPI DF + Sbjct: 77 -----------MNTGSCLPHLLSH--FYQNLGPGTIRLAARIYLQKGFPIKDDFLEQSER 123 Query: 243 YYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNK 302 + A+ ++ N + + T+G I+D L + +T +++LN I+F G W K Sbjct: 124 LFGAKPVKLTGKQEEDLANINQWVKEATEGKIEDFLSELPDSTVLLLLNAIHFHGFWRTK 183 Query: 303 FPVEMTHNHNFRLNEREVVKVSMMQTKGN----FLAANDQELDCDILQLEYVGGISMLIV 358 F +T F L+ER V V MM FL ++ + + + +S ++V Sbjct: 184 FDPSLTQKDFFHLDERFTVSVDMMHAVSYPLRWFLL---EQPEIQVAHFPFKNNMSFVVV 240 Query: 359 VPHKMS-GMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRML 417 +P + + A LT + + S+ R +V LPK L++ +LV +L +G++ L Sbjct: 241 MPTYFEWNVSEVLANLTWDTL--YHPSLQERPTKVWLPKLHLQQQLDLVATLSQLGLQEL 298 Query: 418 FDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGF--MPLSTQVRFTVDRPF 475 F + ++ GIS+Q + + +HQ T+ ++E G +A T+V M LS+ FTV+RPF Sbjct: 299 F-QGPDLRGISEQNLVVSSVQHQSTMELSEAGVEAAAATSVAMNRMSLSS---FTVNRPF 354 Query: 476 LFLIYEHRTSCLLFMGRVANPSRS 499 LF I E LF+G V NP+ S Sbjct: 355 LFFIMEDTIGVPLFVGSVRNPNPS 378 >2XN5-A nrPDB Length = 350 Score = 147 bits (371), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 99/348 (28%), Positives = 177/348 (50%), Gaps = 12/348 (3%) Query: 121 SRIQRLNILNAKFAFNLYRVLKDQVNTFD-NIFIAPVGISTAMGMISLGLKGETHEQVHS 179 + + +++ +NA FAFNLYR + V T D NIF +PV IS A+ M+S G T ++ Sbjct: 6 ATLYKMSSINADFAFNLYR--RFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVE 63 Query: 180 ILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTK 239 L F + + I + F+ L L L+ N L+I K L F Sbjct: 64 TLGFN-----LTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLND 118 Query: 240 VREYYFAEAQIADFSD-PAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGS 298 V+ Y E DFS+ A + N+H+ TKG + ++++ P T M+++N I+FK Sbjct: 119 VKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQ 178 Query: 299 WVNKF-PVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLI 357 W N F P + + +F +++ V+V MM + D EL+C +LQ++Y L Sbjct: 179 WANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALF 238 Query: 358 VVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRML 417 V+P K M+++EA ++ + +++W + + ++ +PKF + Y+L +L MGI+ Sbjct: 239 VLP-KEGQMESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHA 297 Query: 418 FDKNGNMAGIS-DQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLS 464 + +N + +G++ D + + H+ + + E+GT+A + +P S Sbjct: 298 YSENADFSGLTEDNGLKLSNAAHKAVLHIGEKGTEAAGAMFLEAIPRS 345 >1QMB-A nrPDB Length = 326 Score = 147 bits (370), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 96/325 (29%), Positives = 179/325 (55%), Gaps = 11/325 (3%) Query: 131 AKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNAS 190 A+FAF+LYR L Q +T NIF +PV I+TA M+SLG K +TH+++ L+F N + Sbjct: 7 AEFAFSLYRQLAHQSST--NIFFSPVSIATAFAMLSLGTKADTHDEILEGLNF----NLT 60 Query: 191 SKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQI 250 E IH F++L L + + L + N L++ + ++ F V++ Y +EA Sbjct: 61 EIPE-AAIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFT 119 Query: 251 ADFSDPAFISK-TNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTH 309 +F D K N+++ K T+G I D ++ +D T ++N I+FKG W F V+ T Sbjct: 120 VNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTE 179 Query: 310 NHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTL 369 +F +++ VKV MM+ G F + ++L +L ++Y+G + + +P + ++ L Sbjct: 180 EEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDE-GKLQHL 238 Query: 370 EAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISD 429 E +LT ++ ++ ++ R+ + LPK + Y+L L +GI +F +++G+++ Sbjct: 239 ENELTHDIITKFLEN-DRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTE 297 Query: 430 QR-IAIDLFKHQGTITVNEEGTQAT 453 + + + H+ +T++E+GT+A Sbjct: 298 EAPLKLSKAVHKAVLTIDEKGTEAA 322 >4DY0-A nrPDB Length = 379 Score = 147 bits (370), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 102/362 (28%), Positives = 184/362 (50%), Gaps = 26/362 (7%) Query: 149 DNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHR 208 DNI I+P GI++ +GM+ LG G T +Q+ ++ +Y + + + +K+ Sbjct: 30 DNIVISPHGIASVLGMLQLGADGRTKKQLAMVM----------RYGVNGVGKILKKINKA 79 Query: 209 LFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTNNHIMK 268 + + + N ++++ I + F T+ ++ + E + +F DPA + N +K Sbjct: 80 IVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVK 139 Query: 269 -LTKGLIKDALEN--IDPA-TQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVS 324 T+ +I + L ID T+++++N +YFKG W ++F E T F + + +V Sbjct: 140 NETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVP 199 Query: 325 MMQT-----KGNFLAANDQELDCDILQLEYVG-GISMLIVVPHKMS-GMKTLEAQLTPRV 377 M+ G+ A ND L + ++L Y G ISMLI +P + S + + ++ + Sbjct: 200 MLAQLSVFRCGSTSAPND--LWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKT 257 Query: 378 VERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKN-GNMAGIS--DQRIAI 434 ++ W M + +V+LPKF +L E LK++GI +FD + N A I+ + + + Sbjct: 258 IDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHV 317 Query: 435 DLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVA 494 + I V+E+GT+A+ TT + S+ F VDRPFLF I + T +LFMG++ Sbjct: 318 SHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQIN 377 Query: 495 NP 496 P Sbjct: 378 KP 379 >6F02-A nrPDB Length = 389 Score = 145 bits (366), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 113/381 (29%), Positives = 187/381 (49%), Gaps = 21/381 (5%) Query: 130 NAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNA 189 NA FAF Y ++ + NIF +P+ IS A M+SLG + Q+ L F N Sbjct: 11 NADFAFRFYYLIASETPG-KNIFFSPLSISAAYAMLSLGACSHSRSQILEGLGF----NL 65 Query: 190 SSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQ 249 + E + +H F+ L H L G R + L++ L F Y A+ Sbjct: 66 TELSE-SDVHRGFQHLLHTLNLPGHGLETRVGSALFLSHNLKFLAKFLNDTMAVYEAKLF 124 Query: 250 IADFSDP-AFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMT 308 +F D I N+H+ K T+G I D + + M+++N IYFK W F T Sbjct: 125 HTNFYDTVGTIQLINDHVKKETRGKIVDLVSELKKDVLMVLVNYIYFKALWEKPFISSRT 184 Query: 309 HNHNFRLNEREVVKVSMM-QTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMK 367 +F ++E V+V MM Q + + +D+ L C +L+++Y G ++ ++P++ M+ Sbjct: 185 TPKDFYVDENTTVRVPMMLQDQEHHWYLHDRYLPCSVLRMDYKGDATVFFILPNQ-GKMR 243 Query: 368 TLEAQLTPRVVERWQKSMTNRT----REVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGN 423 +E LTP ++ RW + R E+ LPKF + +Y L + L +G LF K + Sbjct: 244 EIEEVLTPEMLMRWNNLLRKRNFYKKLELHLPKFSISGSYVLDQILPRLGFTDLFSKWAD 303 Query: 424 MAGIS-DQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQ-----VRFTVDRPFLF 477 ++GI+ Q++ H+ T+ V+E GT+A T+ S Q +RF +RPFL Sbjct: 304 LSGITKQQKLEASKSFHKATLDVDEAGTEAAAATSFAIKFFSAQTNRHILRF--NRPFLV 361 Query: 478 LIYEHRTSCLLFMGRVANPSR 498 +I+ T +LF+G+V +P++ Sbjct: 362 VIFSTSTQSVLFLGKVVDPTK 382 >5NCS-A nrPDB Length = 375 Score = 145 bits (365), Expect = 5e-35, Method: Compositional matrix adjust. Identities = 109/390 (27%), Positives = 182/390 (46%), Gaps = 36/390 (9%) Query: 119 GKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVH 178 G +I++ N FAF+L + + V T N+FI+P+ +S A+ M G G T +++ Sbjct: 4 GSEKIEKDN----AFAFDLLQTTRKHV-TEANVFISPLSVSMALNMTLNGAAGVTADEMK 58 Query: 179 SILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKT 238 + L + Y + I+ L L + + T+ N ++ ++ + F Sbjct: 59 TALR-------ETGYTMEDINEYSHSLREALLKVDPSTTIGMANSIWYKQGELVKEPFIL 111 Query: 239 KVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGS 298 R +Y AE + DFS PA + N + T I L+ I M ++N +YFKG Sbjct: 112 ANRTHYDAEVKAVDFSSPATLPAINGWCAQKTNDKITKILDYIPGNAFMYLINAVYFKGI 171 Query: 299 WVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-GISMLI 357 WV +F T FR + +V+MM K F D+ C L+++Y SM++ Sbjct: 172 WVTQFKKSDTKRAPFRKADGTTQEVNMMAQKSTFGYTTDE--CCQYLEMDYGNKAFSMIV 229 Query: 358 VVPHKMSGMKTLEAQLTPRVVER-----WQ---KSMTNRTREVLLPKFKLEKNYNLVES- 408 ++P+ E Q T V+E+ W K + + +P+FK E Y L + Sbjct: 230 MLPN--------EGQTTRDVIEQLDNKHWSMIIKGIRPTQVSLRMPRFKTECKYGLEKKI 281 Query: 409 LKLMGIRMLFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFM----PLS 464 L MG+ + F + + GI+D I I H+ + V+EEGT+A VT V + P + Sbjct: 282 LPEMGMNVPFTETADFPGITDAAIFISRVIHKTFVQVDEEGTEAAAVTAVEMVKTSSPST 341 Query: 465 TQVRFTVDRPFLFLIYEHRTSCLLFMGRVA 494 T + F +++PF+F I E T +LF+G + Sbjct: 342 TPINFHINKPFVFAIREKSTGVILFIGEIG 371 >1C8O-A nrPDB Length = 300 Score = 136 bits (343), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 84/314 (26%), Positives = 157/314 (50%), Gaps = 32/314 (10%) Query: 149 DNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHR 208 +N+FI+P IS+ + ++ G G T EQ+ + K+ +++ ++ + + Sbjct: 14 ENVFISPPSISSVLTILYYGANGSTAEQLSKYVE-KEADKNKDDISFKSMNKVYGRYS-A 71 Query: 209 LFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTNNHIMK 268 +F+ +F LR + D + Q DF+D + N + Sbjct: 72 VFKDSF---LRKIGDNF-----------------------QTVDFTDSRTVDAINKSVDI 105 Query: 269 LTKGLIKDAL-ENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQ 327 T+G I L E + P T ++ ++ +YFK W+ F E T ++ F ++ E+V VSMM Sbjct: 106 FTEGKINPLLDEPLSPDTSLLAISAVYFKAKWLMPFEKEFTSDYPFYVSPTEMVDVSMMS 165 Query: 328 TKG---NFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKS 384 G N + + + I++L YVG SM++++P + G++++E LT ++W S Sbjct: 166 MYGEAFNHASVKESFGNFSIIELPYVGDTSMVVILPDNIDGLESIEQNLTDTNFKKWSDS 225 Query: 385 MTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKHQGTIT 444 M +V +PKFK+ +YNLV++L +G+ +F G+ + +S+ +++D H+ I Sbjct: 226 MDAMFIDVHIPKFKVTGSYNLVDALVKLGLTEVFGSTGDYSNMSNSDVSVDAMIHKTYID 285 Query: 445 VNEEGTQATTVTTV 458 VNEE T+A T+ Sbjct: 286 VNEEYTEAAAATSA 299 >1IMV-A nrPDB Length = 398 Score = 135 bits (339), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 96/383 (25%), Positives = 187/383 (48%), Gaps = 21/383 (5%) Query: 120 KSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHS 179 K + +L + F ++LYRV + ++ N+ ++P+ ++TA+ +SLG T +H Sbjct: 28 KVPVNKLAAAVSNFGYDLYRV-RSSMSPTTNVLLSPLSVATALSALSLGADERTESIIHR 86 Query: 180 ILHFKDFVNASSKYEITTIHNLFRKL--THRLFRRNFGYTLRSVNDLYIQKQFPILLDFK 237 L++ D +++ IH +++L T ++N L+S + + +K+ I F Sbjct: 87 ALYY-DLISSPD------IHGTYKELLDTVTAPQKN----LKSASRIVFEKKLRIKSSFV 135 Query: 238 TKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKG 297 + + Y ++ + + + NN + KG + + + I +++L +FKG Sbjct: 136 APLEKSYGTRPRVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGVAHFKG 195 Query: 298 SWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAAN-DQELDCDILQLEYVGGISML 356 WV KF T +F L+E V+V MM L D +L C I QL G +S++ Sbjct: 196 QWVTKFDSRKTSLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSII 255 Query: 357 IVVPHKMSGMKTL-EAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIR 415 +P K++ TL E LT + + + + +PK KL + +SL+ M ++ Sbjct: 256 FFLPLKVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQ 315 Query: 416 MLFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMP--LSTQVRFTVDR 473 LFD + + + I+ + I + +H+ NE+G A T + G P L+ + + +++ Sbjct: 316 SLFD-SPDFSKITGKPIKLTQVEHRAGFEWNEDG--AGTTPSPGLQPAHLTFPLDYHLNQ 372 Query: 474 PFLFLIYEHRTSCLLFMGRVANP 496 PF+F++ + T LLF+G++ +P Sbjct: 373 PFIFVLRDTDTGALLFIGKILDP 395 >1C5G-A nrPDB Length = 402 Score = 130 bits (328), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 98/359 (27%), Positives = 171/359 (47%), Gaps = 22/359 (6%) Query: 150 NIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRL 209 N+ +P G+++ + M+ L GET +Q+ + + FK K + +L+++L Sbjct: 54 NVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFK----IDDKGMAPALRHLYKELMGPW 109 Query: 210 FRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSD---PAFISKTNNHI 266 + T + +++Q+ ++ F + + + DFS+ FI N+ + Sbjct: 110 NKDEISTT----DAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFI--INDWV 163 Query: 267 MKLTKGLIKDALEN--IDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVS 324 TKG+I + L +D T+++++N +YF G W FP TH F ++ V V Sbjct: 164 KTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVP 223 Query: 325 MMQTKGNFLAANDQELDC---DILQLEYVGG-ISMLIVVPH-KMSGMKTLEAQLTPRVVE 379 MM F D DIL+L Y G +SM I P+ K + L L+ +++ Sbjct: 224 MMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLIS 283 Query: 380 RWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDK-NGNMAGISDQR-IAIDLF 437 W+ +MT R ++LPKF LE +L + L+ +G+ +F + + +SDQ + + Sbjct: 284 HWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQA 343 Query: 438 KHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496 + I VNE GT A++ T V +DRPFLF++ + T +LFMG+V P Sbjct: 344 LQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP 402 >4P0F-A nrPDB Length = 393 Score = 129 bits (325), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 105/375 (28%), Positives = 174/375 (46%), Gaps = 24/375 (6%) Query: 131 AKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNAS 190 A F+ N+Y L Q +NI +P I T M LG + ET Q+ L AS Sbjct: 15 ALFSINVYGKLSGQ-KPGENIVFSPFSIQTCAAMARLGAENETATQLDQGLGL-----AS 68 Query: 191 SKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQI 250 S E I + F ++ L LR N +++ + + +F + + + + AQ Sbjct: 69 SDPE--QIAHSFHQV---LAAYQDSQILRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQS 123 Query: 251 ADFSDPAFISKT-NNHIMKLTKGLIKDAL--ENIDPATQMMILNCIYFKGSWVNKFPVEM 307 DFS + T NN + + T LIKD + + ++ ++++++N I+FKG+W ++F + Sbjct: 124 VDFSKNVQAAATINNWVEQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHL 183 Query: 308 THNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYV-GGISMLIVVPHKMSGM 366 T F L+ V+V MM K F A+ LD L+L Y +SMLIV+P+ +G+ Sbjct: 184 TRPDTFHLDGERTVQVPMMSLKERFRYADLPALDAMALELPYKDSDLSMLIVLPNTKTGL 243 Query: 367 KTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAG 426 LE +L + + +S+ + LP+FK E L E + +G+ +F Sbjct: 244 PALEEKLRLTTLSQITQSLYETKVALKLPRFKAEFQVELSEVFQKLGMSRMFSDQAEFGK 303 Query: 427 I--SDQRIAIDLFKHQGTITVNEEGTQATTVTTV------GFMPLSTQVRFTVDRPFLFL 478 + S + + + H+ I VNEEGT+A T + M + F D PF ++ Sbjct: 304 MLQSPEPLKVSAIIHKAFIEVNEEGTEAAAATGMAVRRKRAIMSPEEPIEFFADHPFTYV 363 Query: 479 IYEHRTSCLLFMGRV 493 + H+ LF G V Sbjct: 364 LV-HQKDLPLFWGSV 377 >3LW2-A nrPDB Length = 379 Score = 129 bits (323), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 101/367 (27%), Positives = 173/367 (47%), Gaps = 38/367 (10%) Query: 150 NIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRL 209 N+ +P G+S+ + M+ + G+T Q+ + FK VN E T H L R+L+ L Sbjct: 31 NVVFSPYGVSSVLAMLQMTTAGKTRRQIQDAMGFK--VN-----EKGTAHAL-RQLSKEL 82 Query: 210 FRRNFGYTLRSVNDLYIQKQFPILLDF--------KTKVREYYFAEAQIADFSDPAFISK 261 + + + +++Q+ ++ F +T V++ F+E + A F Sbjct: 83 MGPWNKNEISTADAIFVQRDLELVQGFMPHFFKLFQTMVKQVDFSEVERARFI------- 135 Query: 262 TNNHIMKLTKGLIKDALEN--IDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNERE 319 N+ + + TKG+I D L +D T+++++N +YF G W F TH F ++ Sbjct: 136 INDWVERHTKGMINDLLAKGAVDELTRLVLVNALYFSGQWKTPFLEASTHQRLFHKSDGS 195 Query: 320 VVKVSMMQTKGNFLAANDQE------LDCDILQLEYVGG-ISMLIVVP-HKMSGMKTLEA 371 V V MM F N E L+ D+++L Y G +SM I P K + L Sbjct: 196 TVSVPMMAQSNKF---NYTEFTTPDGLEYDVVELPYQGDTLSMFIAAPFEKDVHLSALTN 252 Query: 372 QLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKN-GNMAGISDQ 430 L ++ +W+ +MT R ++LPKF LE +L L+ +G+ +F + +SDQ Sbjct: 253 ILDAELIRQWKGNMTRLPRLLILPKFSLETEVDLRGPLEKLGMPDMFSATLADFTSLSDQ 312 Query: 431 -RIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLF 489 ++++ + I VNE GT A++ T +DR FLF++ + T +LF Sbjct: 313 EQLSVAQALQKVRIEVNESGTVASSSTAFVISARMAPTEMVIDRSFLFVVRHNPTETILF 372 Query: 490 MGRVANP 496 MG+V P Sbjct: 373 MGQVMEP 379 >1M93-B nrPDB Length = 245 Score = 128 bits (321), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 67/213 (31%), Positives = 118/213 (55%), Gaps = 4/213 (1%) Query: 249 QIADFSDPAFISKTNNHIMKLTKGLIKDAL-ENIDPATQMMILNCIYFKGSWVNKFPVEM 307 Q DF+D + N + T+G I L E + P T ++ ++ +YFK W+ F E Sbjct: 31 QTVDFTDSRTVDAINKSVDIFTEGKINPLLDEPLSPDTSLLAISAVYFKAKWLMPFEKEF 90 Query: 308 THNHNFRLNEREVVKVSMMQTKG---NFLAANDQELDCDILQLEYVGGISMLIVVPHKMS 364 T ++ F ++ E+V VSMM G N + + + I++L YVG SM++++P + Sbjct: 91 TSDYPFYVSPTEMVDVSMMSMYGEAFNHASVKESFGNFSIIELPYVGDTSMVVILPDNID 150 Query: 365 GMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNM 424 G++++E LT ++W SM +V +PKFK+ +YNLV++L +G+ +F G+ Sbjct: 151 GLESIEQNLTDTNFKKWSDSMDAMFIDVHIPKFKVTGSYNLVDALVKLGLTEVFGSTGDY 210 Query: 425 AGISDQRIAIDLFKHQGTITVNEEGTQATTVTT 457 + +S+ +++D H+ I VNEE T+A T+ Sbjct: 211 SNMSNSDVSVDAMIHKTYIDVNEEYTEAAAATS 243 >3OZQ-A nrPDB Length = 376 Score = 127 bits (318), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 97/363 (26%), Positives = 178/363 (49%), Gaps = 42/363 (11%) Query: 150 NIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRL 209 N ++P +T + + G +G+T E++ +LHF V K E + + KLT Sbjct: 33 NFLVSPFSAATLLALAQSGCRGDTAEEIRQVLHF---VGDREKAE-GAVKEVLSKLT--- 85 Query: 210 FRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTNNHIMKL 269 N YTL + N +Y++ F + +F+ E Y A+++ DFS+ N KL Sbjct: 86 ---NEEYTLHTANKIYVKTNFSVREEFQKIAVEVYGAQSENVDFSE-------KNDAAKL 135 Query: 270 TKGLIKDALEN-----IDPA-----TQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNERE 319 +++ ++ +DP T+++++N +YF W+ FP T +F + +E Sbjct: 136 MNAWVEEQTQHKIQNLVDPEILNNLTRVVLINALYFNAKWLVPFPPFHTRKSDFHKSAKE 195 Query: 320 VVKVSMMQTKGNFLAAND-QELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVV 378 VV+V M + + LD +L+L + GG S+ IV+ +++ G+ +LE+++ + Sbjct: 196 VVQVDTMYLDEQYFNYYECHHLDAKLLELPFKGGASLTIVLSNQIEGLVSLESKIKRSFL 255 Query: 379 ERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQR--IAIDL 436 ++T + V LPKFK+E + + LK +G++ F +++GI+ ++ + I Sbjct: 256 PH---NLTKQLVNVALPKFKIESTVDFKKVLKKLGVKKAFGDEADLSGIAGEKGDLVISN 312 Query: 437 FKHQGTITVNEEGTQATTVTTVGF------MPLSTQVRFTVDRPFLFLIYEHRTSCLLFM 490 + I V+EEG +A T + +P S + +F VD PF+F I +LF Sbjct: 313 IVQKSFIDVSEEGVEAAAATYIPVILPEMALPDSPK-QFIVDHPFIFYI--KVKGMILFA 369 Query: 491 GRV 493 GRV Sbjct: 370 GRV 372 >6F4U-A nrPDB Length = 341 Score = 125 bits (314), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 93/324 (28%), Positives = 155/324 (47%), Gaps = 14/324 (4%) Query: 130 NAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNA 189 NA FAF Y ++ + NIF +P+ IS A M+SLG + Q+ L F N Sbjct: 9 NADFAFRFYYLIASETPG-KNIFFSPLSISAAYAMLSLGACSHSRSQILEGLGF----NL 63 Query: 190 SSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQ 249 + E + +H F+ L H L G R + L++ L F Y A+ Sbjct: 64 TELSE-SDVHRGFQHLLHTLNLPGHGLETRVGSALFLSHNLKFLAKFLNDTMAVYEAKLF 122 Query: 250 IADFSDP-AFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMT 308 +F D I N+H+ K T+G I D + + M+++N IYFK W F T Sbjct: 123 HTNFYDTVGTIQLINDHVKKETRGKIVDLVSELKKDVLMVLVNYIYFKALWEKPFISSRT 182 Query: 309 HNHNFRLNEREVVKVSMM-QTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMK 367 +F ++E V+V MM Q + + +D+ L C +L+++Y G ++ ++P++ M+ Sbjct: 183 TPKDFYVDENTTVRVPMMLQDQEHHWYLHDRYLPCSVLRMDYKGDATVFFILPNQ-GKMR 241 Query: 368 TLEAQLTPRVVERWQKSMTNRT----REVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGN 423 +E LTP ++ RW + R E+ LPKF + +Y L + L +G LF K + Sbjct: 242 EIEEVLTPEMLMRWNNLLRKRNFYKKLELHLPKFSISGSYVLDQILPRLGFTDLFSKWAD 301 Query: 424 MAGIS-DQRIAIDLFKHQGTITVN 446 ++GI+ Q++ H+ T+ V+ Sbjct: 302 LSGITKQQKLEASKSFHKATLDVD 325 >1JJO-C nrPDB Length = 261 Score = 122 bits (307), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 75/260 (28%), Positives = 139/260 (53%), Gaps = 13/260 (5%) Query: 216 YTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFS-DPAFISKTNNHIMKLTKGLI 274 Y ++ N L++Q F + +F ++ Y+ AE DFS + A + N + T L+ Sbjct: 4 YVMKLANSLFVQNGFHVNEEFLQMLKMYFNAEVNHVDFSQNVAVANSINKWVENYTNSLL 63 Query: 275 KDAL--ENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNF 332 KD + E+ D T + ++N +YFKG+W ++F E T +F ++ V++ MM +G F Sbjct: 64 KDLVSPEDFDGVTNLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEF 123 Query: 333 L------AANDQELDCDILQLEYVGG-ISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSM 385 +N+ +L++ Y G ISM++ + + + TLE L +++E W S+ Sbjct: 124 YYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLALSRQEVPLATLEPLLKAQLIEEWANSV 183 Query: 386 TNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQR-IAIDLFKHQGTIT 444 + EV LP+F +E+ +L + LK +G+ +F K+ N+ +SD++ + + H+ I Sbjct: 184 KKQKVEVYLPRFTVEQEIDLKDILKALGVTEIFIKDANLTAMSDKKELFLSKAVHKSCIE 243 Query: 445 VNEEGTQATTVTTVGFMPLS 464 VNEEG++A + G + +S Sbjct: 244 VNEEGSEAAAAS--GMIAIS 261 >3ZHA-A nrPDB Length = 392 Score = 122 bits (307), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 97/374 (25%), Positives = 175/374 (46%), Gaps = 18/374 (4%) Query: 130 NAKFAFNLYRVL-KDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVN 188 +A AF+LY+ + KDQ +NI ++PV +++++G++SLG K T Q ++L + + Sbjct: 13 SAGLAFSLYQAMAKDQA--VENILLSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRD 70 Query: 189 ASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEA 248 + L R L++ RN + L S LY DF +++Y E Sbjct: 71 EEVH---AGLGELLRSLSNST-ARNVTWKLGS--RLYGPSSVSFAEDFVRSSKQHYNCEH 124 Query: 249 QIADFSDP-AFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEM 307 +F D + + N + T G + + ++++ +++N ++FK W KF +M Sbjct: 125 SKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKM 184 Query: 308 THNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVV-PHKMSGM 366 N F + V V+MM G + +D++ I+++ +S LI++ PH + + Sbjct: 185 VDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPL 244 Query: 367 KTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKN----G 422 + LE LT ++ W M + + LPK +E ++L + L +G+ DKN Sbjct: 245 ERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLS 304 Query: 423 NMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEH 482 M+G D +A +F H + EG G L + F D PF+FL+ + Sbjct: 305 RMSGKKDLYLA-SVF-HATAFEWDTEGNPFDQ-DIYGREELRSPKLFYADHPFIFLVRDT 361 Query: 483 RTSCLLFMGRVANP 496 ++ LLF+GR+ P Sbjct: 362 QSGSLLFIGRLVRP 375 >5NCU-A nrPDB Length = 336 Score = 122 bits (305), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 97/350 (27%), Positives = 160/350 (45%), Gaps = 32/350 (9%) Query: 119 GKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVH 178 G +I++ N FAF+L + + V T N+FI+P+ +S A+ M G G T +++ Sbjct: 4 GSEKIEKDN----AFAFDLLQTTRKHV-TEANVFISPLSVSMALNMTLNGAAGVTADEMK 58 Query: 179 SILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKT 238 + L + Y + I+ L L + + T+ N ++ ++ + F Sbjct: 59 TALR-------ETGYTMEDINEYSHSLREALLKVDPSTTIGMANSIWYKQGELVKEPFIL 111 Query: 239 KVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGS 298 R +Y AE + DFS PA + N + T I L+ I M ++N +YFKG Sbjct: 112 ANRTHYDAEVKAVDFSSPATLPAINGWCAQKTNDKITKILDYIPGNAFMYLINAVYFKGI 171 Query: 299 WVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-GISMLI 357 WV +F T FR + +V+MM K F D+ C L+++Y SM++ Sbjct: 172 WVTQFKKSDTKRAPFRKADGTTQEVNMMAQKSTFGYTTDE--CCQYLEMDYGNKAFSMIV 229 Query: 358 VVPHKMSGMKTLEAQLTPRVVER-----WQ---KSMTNRTREVLLPKFKLEKNYNLVES- 408 ++P+ E Q T V+E+ W K + + +P+FK E Y L + Sbjct: 230 MLPN--------EGQTTRDVIEQLDNKHWSMIIKGIRPTQVSLRMPRFKTECKYGLEKKI 281 Query: 409 LKLMGIRMLFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTV 458 L MG+ + F + + GI+D I I H+ + V+EEGT+A VT V Sbjct: 282 LPEMGMNVPFTETADFPGITDAAIFISRVIHKTFVQVDEEGTEAAAVTAV 331 >3LE2-A nrPDB Length = 393 Score = 121 bits (304), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 100/390 (25%), Positives = 171/390 (43%), Gaps = 31/390 (7%) Query: 129 LNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVN 188 L + + NL + + V+ N+ +P I+ + +I+ G G T +Q+ S L F Sbjct: 11 LQNQVSMNLAKHVITTVSQNSNVIFSPASINVVLSIIAAGSAGATKDQILSFLKF----- 65 Query: 189 ASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEA 248 SS ++ + + N G L N +I K FK + + Y A + Sbjct: 66 -SSTDQLNSFSSEIVSAVLADGSANGGPKLSVANGAWIDKSLSFKPSFKQLLEDSYKAAS 124 Query: 249 QIADFSDPAF--ISKTNNHIMKLTKGLIKDALE--NIDPATQMMILNCIYFKGSWVNKFP 304 ADF A I++ N+ K T GLI + L + D T+++ N +YFKG+W KF Sbjct: 125 NQADFQSKAVEVIAEVNSWAEKETNGLITEVLPEGSADSMTKLIFANALYFKGTWNEKFD 184 Query: 305 VEMTHNHNFR-LNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGG-----ISMLIV 358 +T F L+ +V M K +++A D +L L Y+ G SM Sbjct: 185 ESLTQEGEFHLLDGNKVTAPFMTSKKKQYVSAYD---GFKVLGLPYLQGQDKRQFSMYFY 241 Query: 359 VPHKMSGMKTLEAQL--TPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRM 416 +P +G+ L ++ TP ++ + RE +PKFK ++ LK +G+ Sbjct: 242 LPDANNGLSDLLDKIVSTPGFLDNHIPRRQVKVREFKIPKFKFSFGFDASNVLKGLGLTS 301 Query: 417 LFDKNGNMAGISD-----QRIAIDLFKHQGTITVNEEGTQATTVTTV-----GFMPLSTQ 466 F + + + + + + H+ I VNEEGT+A + G + + Sbjct: 302 PFSGEEGLTEMVESPEMGKNLCVSNIFHKACIEVNEEGTEAAAASAGVIKLRGLLMEEDE 361 Query: 467 VRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496 + F D PFL ++ E+ T +LF+G+V +P Sbjct: 362 IDFVADHPFLLVVTENITGVVLFIGQVVDP 391 >4KDS-A nrPDB Length = 386 Score = 118 bits (296), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 94/362 (25%), Positives = 172/362 (47%), Gaps = 25/362 (6%) Query: 149 DNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHR 208 N+ +P G++T + M LG G T + +++ L F ++ + +L R Sbjct: 37 SNLAFSPYGVATILAMAQLGAGGNTLKTLNAKLGFSLQERGMARQQ---------RLLQR 87 Query: 209 LFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDP-AFISKTNNHIM 267 G L S + ++++ + F+ + + + A DFS P + N + Sbjct: 88 DISSEEGVELAS--GVMVERKMALEKGFRRGLGKAFQASPHQLDFSRPDQALDIINAWVS 145 Query: 268 KLTKGLIKDALEN--IDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSM 325 T G I L + + T+M++LN ++F+G W F +MT F V V M Sbjct: 146 DHTAGTIPSFLSSGALTDETRMVLLNALHFQGLWKVPFDPKMTEERLFHCANGSSVPVPM 205 Query: 326 MQTK-----GNFLAANDQELDCDILQLEYVG-GISMLIVVP-HKMSGMKTLEAQLTPRVV 378 M+ G F+ + +D D++++ Y G +SML+V P + + +L ++LT + + Sbjct: 206 MRLTHRFKYGEFVTPDG--VDYDVIEVPYEGESLSMLLVSPFEPETPVSSLSSELTTQRL 263 Query: 379 ERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFD-KNGNMAGIS-DQRIAIDL 436 ++W++ M + R+++LP+F L+ L L MG+ +F+ + I+ +Q + + Sbjct: 264 QQWRQEMRSVKRQLVLPRFTLDSEVELKSILIQMGLGDMFNLAKADFTRITTEQPLCVSK 323 Query: 437 FKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496 + I VNEEGT+A+ T T++RPFLFLI+ T +LFMG+V P Sbjct: 324 VLQKVKIEVNEEGTKASAATAAILFSRMAVEEITMNRPFLFLIHHKSTGAVLFMGQVNQP 383 Query: 497 SR 498 + Sbjct: 384 QQ 385 >1K9O-I nrPDB Length = 378 Score = 117 bits (293), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 103/371 (27%), Positives = 178/371 (47%), Gaps = 38/371 (10%) Query: 144 QVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFR 203 + N N+ ++ + +G ++L GE+H+++ L + ++F Sbjct: 28 KANPGQNVVLSAFSVLPPLGQLALASVGESHDELLRALALPN---------DNVTKDVFA 78 Query: 204 KLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFIS--- 260 L +R R G L+ + +Y+ K + DF R+ + +E Q DF + Sbjct: 79 DL-NRGVRAVKGVDLKMASKIYVAKGLELNDDFAAVSRDVFGSEVQNVDFVKSVEAAGAI 137 Query: 261 ------KTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFR 314 +TNN I L DAL D T+ +++N IYFKGSW +KF E T + +F Sbjct: 138 NKWVEDQTNNRIKNLVD---PDAL---DETTRSVLVNAIYFKGSWKDKFVKERTMDRDFH 191 Query: 315 LNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGG-ISMLIVVPHKMSGMKTLEAQL 373 +++ + +KV M K + A+ ELD ++++ Y G SM+I++P+++ G+ LE +L Sbjct: 192 VSKDKTIKVPTMIGKKDVRYADVPELDAKMIEMSYEGDQASMIIILPNQVDGITALEQKL 251 Query: 374 T-PRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNG----NMAGIS 428 P+ + R ++ + N E+ LPKFK+E +L E L M I+ LF N+ + Sbjct: 252 KDPKALSRAEERLYNTEVEITLPKFKIETTTDLKEVLSNMNIKKLFTPGAARLENLLK-T 310 Query: 429 DQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQV--RFTVDRPFLFLIYEHRTSC 486 + + +D + I VNEEG +A G +P S + +DRPF F E + Sbjct: 311 KESLTVDAAIQKAFIEVNEEGAEAAAANAFGIVPKSLILYPEVHIDRPFYF---ELKIDG 367 Query: 487 L-LFMGRVANP 496 + +F G+V P Sbjct: 368 IPMFNGKVIEP 378 >1SEK-A nrPDB Length = 378 Score = 114 bits (284), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 81/286 (28%), Positives = 142/286 (49%), Gaps = 27/286 (9%) Query: 144 QVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFR 203 + N N+ ++ + +G ++L GE+H+++ L + ++F Sbjct: 28 KANPGQNVVLSAFSVLPPLGQLALASVGESHDELLRALALPN---------DNVTKDVFA 78 Query: 204 KLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFIS--- 260 L +R R G L+ + +Y+ K + DF R+ + +E Q DF + Sbjct: 79 DL-NRGVRAVKGVDLKMASKIYVAKGLELNDDFAAVSRDVFGSEVQNVDFVKSVEAAGAI 137 Query: 261 ------KTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFR 314 +TNN I L DAL D T+ +++N IYFKGSW +KF E T + +F Sbjct: 138 NKWVEDQTNNRIKNLVD---PDAL---DETTRSVLVNAIYFKGSWKDKFNKERTMDRDFH 191 Query: 315 LNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGG-ISMLIVVPHKMSGMKTLEAQL 373 +++ + +KV M K + A+ ELD ++++ Y G SM+I++P+++ G+ LE +L Sbjct: 192 VSKDKTIKVPTMIGKKDVRYADVPELDAKMIEMSYEGDQASMIIILPNQVDGITALEQKL 251 Query: 374 T-PRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLF 418 P+ + R ++ + N E+ LPKFK+E +L E L M I+ LF Sbjct: 252 KDPKALSRAEERLYNTEVEIYLPKFKIETTTDLKEVLSNMNIKKLF 297 >6CJ7-A nrPDB Length = 390 Score = 109 bits (272), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 94/384 (24%), Positives = 181/384 (47%), Gaps = 41/384 (10%) Query: 133 FAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSK 192 F N+++ + + + N+ +P I+ + M+ G G T +++ L +A Sbjct: 20 FGVNVFKQMATEQS--GNLAASPFSITILLAMLQQGAAGNTLDEITRALQMTPEKSAE-- 75 Query: 193 YEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFK--------TKVREYY 244 +F+K+ + +RN L++ N++++ + F + FK + + Y Sbjct: 76 --------IFKKVNEEIQKRNSRNILKTANNVFLSENFNLNPQFKRIAVNNFDSDLTPTY 127 Query: 245 FAEAQIADFSDPAFI-SKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKF 303 F + +A + ++I SKTN+ I KL + +++ TQM+++N +YFKG W F Sbjct: 128 FGKPALAAQNINSWIASKTNDKIDKLV------SPDDLSGNTQMVMVNAVYFKGLWEIPF 181 Query: 304 PVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEY-VGGISMLIVVPHK 362 + T NF LN E S MQT+ F A + ++ L + S+++V+P K Sbjct: 182 REQATQKRNFTLNGGEKKVASFMQTRRYFKAGTHKPAMAKVVVLPFEYNEYSLIVVLPLK 241 Query: 363 MSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKN- 421 S + L + L+ V + + + + LPKF ++ + NL L MG+ +F + Sbjct: 242 SSNVDALLSSLSMEDVASFL-DLPPKDVALELPKFSIKADINLEPVLNKMGVSSIFTQQA 300 Query: 422 -----GNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLS---TQVRFTVDR 473 G+ +S Q + H +T++E G A T+ + LS + F ++ Sbjct: 301 ELYNLGSHGSLSPQ---VSSALHSAVLTIDERGGSAAAATSFAAVALSYDEPSLYFRANK 357 Query: 474 PFLFLIYEHRTSCLLFMGRVANPS 497 PFL +++++R+S LFM R+ +P+ Sbjct: 358 PFLAILWDNRSSIPLFMARIMDPT 381 >4DTE-A nrPDB Length = 374 Score = 107 bits (267), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 84/361 (23%), Positives = 166/361 (45%), Gaps = 29/361 (8%) Query: 150 NIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRL 209 N+ ++P GI++ +GM +G G T + + S + + K + RL Sbjct: 26 NLALSPYGIASVLGMAQMGAYGATLKLLASKMGYSLQERGMPKLQ-------------RL 72 Query: 210 FRRNFGYT--LRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKT-NNHI 266 +R+ + + + + ++ + F+ + + + + DFS P + N+ Sbjct: 73 LQRDLASEDGVEVASGVMVDRKIILEKVFRRSLSKAFQSVPHQIDFSQPEMARQVINSWT 132 Query: 267 MKLTKGLIKDALEN--IDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVS 324 T G+I + L + + T+++ LN ++F G W F T F V V Sbjct: 133 SDHTDGMISEFLPSGVLSELTRLVFLNALHFHGVWKTPFDPRNTREQLFHTVNGSAVSVP 192 Query: 325 MMQTK-----GNFLAANDQELDCDILQLEYVG-GISMLIVVP-HKMSGMKTLEAQLTPRV 377 MM T G F++ + +D D++++ Y G ISML+V P K + L +L+ Sbjct: 193 MMTTTQKFNYGEFVSKDG--VDYDVIEMPYEGESISMLLVTPFEKDVPLSALNKELSSSR 250 Query: 378 VERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKN-GNMAGIS-DQRIAID 435 + +W++ M ++++ +P+F ++ +L +L MG+ +F ++ + + I+ ++ + + Sbjct: 251 IHQWRQEMRKISKQLSIPRFSMDTEIDLKSTLSRMGLGDIFSQSRADFSRITTEEPLCVS 310 Query: 436 LFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVAN 495 + + VNEEGT+ ++ T T+DRPF FLI T LLF G++ Sbjct: 311 KVLQRVKLEVNEEGTKGSSATAAVIYSRMAVEEITLDRPFFFLIQHKPTGALLFSGQLTQ 370 Query: 496 P 496 P Sbjct: 371 P 371 >3PZF-A nrPDB Length = 397 Score = 102 bits (253), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 95/406 (23%), Positives = 177/406 (43%), Gaps = 45/406 (11%) Query: 115 QLFHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMI------SLG 168 Q HG + QR N + F +++ N N+ ++P + + +I S G Sbjct: 11 QDVHGPFQGQRQNEFDLMFVKEIFK------NHNSNVVLSPFSVKILLTLIYEASDTSFG 64 Query: 169 -LKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQ 227 T ++ S++ D ++ + Y +++L + N Y L + ++ Sbjct: 65 NAVSNTKRELSSVIQ-NDNIDHTRSY--------YKQLLESAQQDNKDYDLNIATNFFVD 115 Query: 228 KQFPILLDFKTKVREYYFAEAQIADFSDPAFISKT-NNHIMKLTKGLIK-----DALENI 281 ++ ++ +Y A + +S+P + T NN + + T G ++ D+LE Sbjct: 116 DFIEVINKYQQIANTHYHAMLEKVSYSNPTQTAATINNWVSEHTNGRLREIVTPDSLE-- 173 Query: 282 DPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELD 341 + ++N IYFKG W FP + F + M+ G F N +L Sbjct: 174 --GAVITLVNVIYFKGLWTYPFPEVANNVKPFYGTRGKPTNAQYMEQNGQFYYDNSADLG 231 Query: 342 CDILQLEYVGG-ISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLE 400 IL+L Y G ++M ++P+ + + + ++ + + M V LPKFK + Sbjct: 232 AQILRLPYRGNKLAMYFILPNPDNTVNQVLDRINSASLHQALWYMEENEVNVTLPKFKFD 291 Query: 401 KNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAID------LFKHQGTITVNEEGTQATT 454 + L E L+ +GIR +F +N ++ ++ R A D +F+ G IT+NE G++A Sbjct: 292 FSEQLNEPLQQVGIREIFSQNASLPLLARGRGARDEVRVSRIFQKAG-ITINELGSEAYA 350 Query: 455 VTTV----GFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496 T + F Q+ F +RPF+F I + +LF G++ NP Sbjct: 351 ATEIQLVNKFGGDGVQI-FNANRPFIFFIEDETLGTMLFAGKIENP 395 >1SNG-A nrPDB Length = 370 Score = 100 bits (249), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 86/374 (22%), Positives = 164/374 (43%), Gaps = 35/374 (9%) Query: 132 KFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASS 191 +FA +L+R L + V + I+ +P ++ A+G+++ G + T ++ Sbjct: 16 EFALHLHRRLAEAVPDGEVIW-SPYSVACALGVLAAGARATTRTEL---------TTLLG 65 Query: 192 KYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIA 251 + L R +T L S L++ P+ F+ + + ++ + A Sbjct: 66 TDPAPLLAALDRAVTD-------SPDLASRTVLWVSADVPVRSSFRATMHDRPDSDVRTA 118 Query: 252 DF-SDPAFISKT-NNHIMKLTKGLIKDALEN--IDPATQMMILNCIYFKGSWVNKFPVEM 307 DF ++P + T N I T+G+I++ L + P + ++ N ++ K W F + Sbjct: 119 DFRTNPEGVRATVNADIADATRGMIRELLPQGAVTPDLRAILTNALWAKARWTTPFEAHL 178 Query: 308 THNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMK 367 T FR R +V M A + ++ L +++ +++P G Sbjct: 179 TRAGTFR-TPRGPKRVPFMHRTKTMPYATAR--GWRMVTLHAHDELAVDVLLP---PGTN 232 Query: 368 TLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGI 427 P + ++S + E+ LP+F+L + + LVE L G+R LF + +++GI Sbjct: 233 AAAVPTAPLLTALHRRSASTSV-ELALPRFELTQPHQLVEVLAEAGVRTLFTASADLSGI 291 Query: 428 SDQRIAIDLFKHQGTITVNEE-----GTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEH 482 S + +D HQ + V+E A + G MP +RF+VDRPF ++ Sbjct: 292 STVPLYVDTVIHQARLRVDERGAEGAAATAAMMLLAGAMPPRRTIRFSVDRPFHIVV--R 349 Query: 483 RTSCLLFMGRVANP 496 R +LF+G +A+P Sbjct: 350 RRGAILFLGSIADP 363 >3STO-A nrPDB Length = 406 Score = 97.8 bits (242), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 87/366 (23%), Positives = 170/366 (46%), Gaps = 18/366 (4%) Query: 149 DNIFIAPVGISTAMGMI--SLGLKGETHEQVHSILHFKDFVNASSKYEITT-IHNLFRKL 205 DN P+GI +G++ S G +G T Q+ + K ++ + E + +L+++L Sbjct: 37 DNFLTCPLGILFTLGILLGSGGAQGRTGYQIGKTMRLKSTSSSWNSSEAQQEMKSLYQEL 96 Query: 206 THRL------FRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSD-PAF 258 + L +R ++++K + + F + E + DFS+ + Sbjct: 97 NNSLTSEKTFLNEKEENVVRISTGIFVEKTYEVERRFNESIANDSEGELKQVDFSNRTSA 156 Query: 259 ISKTNNHIMKLTKGLIKDAL-ENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNE 317 N+ + + + GL++ ++I T M+++N YF+ W + F T +F ++ Sbjct: 157 TVDINDWVDQQSNGLLEKFFTDDIPDDTAMILVNVFYFRDFWQSPFEPHYTRKEDFYISP 216 Query: 318 REVVKVSMMQTKGNFLAANDQELDCDILQLEYVGG-ISMLIVVP-HKMSGMKTLEAQLTP 375 + V MM +G ++ +I+ + +IV+P K S E Sbjct: 217 DRQITVDMMTQEGVMKYGKFEDEGFEIVSKPLNNTRFTFVIVLPLEKWSLNGATELLNGN 276 Query: 376 RVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDK-NGNMAGIS-DQRIA 433 +V+ + K++ T + LPKF L+ +LV +LK +G+ LFD +++GI+ + + Sbjct: 277 KVLSEYVKNLKETTVSLRLPKFTLKNTLDLVPTLKSIGVVDLFDPVKSDLSGITPNPNLY 336 Query: 434 IDLFKHQGTITVNEEGTQATTVTTVGFMPLST---QVRFTVDRPFLFLIYEHRTSCLLFM 490 ++ F + +NE G +ATTVT+ F+P S +V F V PF+ IY+ + + + Sbjct: 337 VNEFIQTNVLKLNESGIEATTVTSPIFVPFSAIIPEVDFHVTHPFICFIYDQQLTMPIMA 396 Query: 491 GRVANP 496 +V NP Sbjct: 397 AKVMNP 402 >2OAY-A nrPDB Length = 390 Score = 92.8 bits (229), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 92/374 (24%), Positives = 167/374 (44%), Gaps = 34/374 (9%) Query: 133 FAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHF-KDFVNASS 191 F+ LY N+ +P I++ + + LG T + SIL + KDF Sbjct: 39 FSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDF----- 93 Query: 192 KYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIA 251 T +H + T + G T SV+ ++ I F R Y + ++ Sbjct: 94 ----TCVHQALKGFTTK------GVT--SVSQIFHSPDLAIRDTFVNASRTLYSSSPRVL 141 Query: 252 DFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNH 311 + A + N + K T I L+++ T++++LN IY W F + T Sbjct: 142 SNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWKTTFDPKKTRME 201 Query: 312 NFRLNEREVVKVSMMQTKGNFLAAN-DQELDCDILQLEYVGGISMLIVVPHKMSG-MKTL 369 F + V+KV MM +K +A DQ L + QL+ +S++I+VP + ++ + Sbjct: 202 PFHF-KNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLKHRLEDM 260 Query: 370 EAQLTPRV----VERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFD--KNGN 423 E L+P V +E+ + S T + LP+ K+ + ++ L +M FD + N Sbjct: 261 EQALSPSVFKAIMEKLEMSKFQPTL-LTLPRIKVTTSQDM---LSIMEKLEFFDFSYDLN 316 Query: 424 MAGIS-DQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEH 482 + G++ D + + +HQ + + E G +A + + T + F V +PFLF++++ Sbjct: 317 LCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVA--RTLLVFEVQQPFLFMLWDQ 374 Query: 483 RTSCLLFMGRVANP 496 + +FMGRV +P Sbjct: 375 QHKFPVFMGRVYDP 388 >2PEF-A nrPDB Length = 373 Score = 81.3 bits (199), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 93/380 (24%), Positives = 164/380 (43%), Gaps = 30/380 (7%) Query: 129 LNAKFAFNL----YRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFK 184 ++ KF +N + K+ ++ +N I+P+ A+ M + G ET Q+ L Sbjct: 5 IDEKFIYNTADFSIELFKNSIDDKENSLISPLSAMLALAMTANGADNETLAQMEKALGKD 64 Query: 185 DFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYY 244 + +KY T + L + +L N + + + F DF + +YY Sbjct: 65 ISIEDLNKYLYTYMKKLPNEEKSKLTIANSIW--------FKENDFMPSKDFLQIIADYY 116 Query: 245 FAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFP 304 A+ A F D + +S NN + T G+I L IDP M ++N + F W + Sbjct: 117 KADIFKAAF-DSSTVSDINNWVKSKTNGMIDKILNKIDPEDVMYLINAVAFDAEWETVYE 175 Query: 305 VEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMS 364 H F KV M ++ N ++E ++ S + ++P + Sbjct: 176 KASVHEDIFTDVYGNRQKVEFMNSEENLYI--EEENAVGFVKPYAKNHYSFVAILPDENI 233 Query: 365 G----MKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLF-- 418 +KTL Q +++ + ++ + LPKFK E + E+L+ +G+ F Sbjct: 234 SVNEYIKTLTGQKFIDLIKNAKITLVRAS----LPKFKYEYTIKMNETLESLGMTDAFLP 289 Query: 419 DK-NGNMAGISD-QRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRF---TVDR 473 DK + + G SD + I H+ I+V+E GT+A VT+V V F ++R Sbjct: 290 DKADFSKLGKSDIGNLYISEVLHKTFISVDELGTKAGAVTSVDITAAGIPVNFKTVKLNR 349 Query: 474 PFLFLIYEHRTSCLLFMGRV 493 PF+F I ++ T+ +F+G V Sbjct: 350 PFIFAIIDNSTNLPIFIGTV 369 >1MTP-A nrPDB Length = 323 Score = 77.0 bits (188), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 69/321 (21%), Positives = 138/321 (42%), Gaps = 28/321 (8%) Query: 132 KFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASS 191 +FA +L+R L + V + I+ +P ++ A+G+++ G + T ++ Sbjct: 12 EFALHLHRRLAEAVPDGEVIW-SPYSVACALGVLAAGARATTRTEL---------TTLLG 61 Query: 192 KYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIA 251 + L R +T L S L++ P+ F+ + + ++ + A Sbjct: 62 TDPAPLLAALDRAVTD-------SPDLASRTVLWVSADVPVRSSFRATMHDRPDSDVRTA 114 Query: 252 DF-SDPAFISKT-NNHIMKLTKGLIKDALEN--IDPATQMMILNCIYFKGSWVNKFPVEM 307 DF ++P + T N I T+G+I++ L + P + ++ N ++ K W F + Sbjct: 115 DFRTNPEGVRATVNADIADATRGMIRELLPQGAVTPDLRAILTNALWAKARWTTPFEAHL 174 Query: 308 THNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMK 367 T FR R +V M A + ++ L +++ +++P G Sbjct: 175 TREGTFR-TPRGPKRVPFMHRTKTMPYATAR--GWRMVTLHAHDELAVDVLLP---PGTN 228 Query: 368 TLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGI 427 P + ++S + E+ LP+F+L + + LVE L G+R LF + +++GI Sbjct: 229 AAAVPTAPLLTALHRRSASTSV-ELALPRFELTQPHQLVEVLAEAGVRTLFTASADLSGI 287 Query: 428 SDQRIAIDLFKHQGTITVNEE 448 S + +D HQ + V+E Sbjct: 288 STVPLYVDTVIHQARLRVDER 308 >5M3Y-A nrPDB Length = 458 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 49/204 (24%), Positives = 96/204 (47%), Gaps = 4/204 (1%) Query: 293 IYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGG 352 ++F+G + F + + F +++ V V M+ G F +D + + Q+ + Sbjct: 249 VHFQGK-MKGFSL-LAEPQEFWVDQSTSVSVPMLSGMGTFQHWSDIQDQFSVTQVPFTES 306 Query: 353 ISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLM 412 S+L++ PH S + +E + W K ++ RT + +P+ L+ +Y+L + L Sbjct: 307 ASLLLIQPHYASDLDKVEGLTFQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQA 366 Query: 413 GIRMLFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVD 472 + + N+ +S+ RI + + + + + T T P +V T++ Sbjct: 367 ELPAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEREPTESTQQLNKPEVLEV--TLN 424 Query: 473 RPFLFLIYEHRTSCLLFMGRVANP 496 RPFLF +Y+ + L F+GRVANP Sbjct: 425 RPFLFAVYDQSATALHFLGRVANP 448 >2WXX-A nrPDB Length = 453 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 61/246 (24%), Positives = 111/246 (45%), Gaps = 8/246 (3%) Query: 254 SDPAFISKTNNHIMKLTKGL-IKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHN 312 +DP ++ N +K G + LE + + ++ ++F+G+ + F ++ H Sbjct: 209 TDPVLATEKINRFIKAVTGWKMNLPLEGVSTDSTLLFNTYVHFQGT-MRGF-SQLPGVHE 266 Query: 313 FRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQ 372 F ++ V V M+ GNF +D + + + + ++L++ PH +S + +EA Sbjct: 267 FWVDNSISVSVPMISGTGNFQHWSDAQNNFSVTCVPLGERATLLLIQPHCISDLDRVEAL 326 Query: 373 LTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISD--Q 430 + + W ++ R + LP+ ++ +YNL + L + L N+ I D Sbjct: 327 IFQNDLLTWIENPPPRAIRLTLPQLEIRGSYNLQDLLAEDKLPTLLGAEANLNNIGDTNP 386 Query: 431 RIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFM 490 R+ L + EE T+V G P + V T+ PFLF IYE + L F+ Sbjct: 387 RVGEVLNSILLELKAGEEEQPTTSVQQPG-SPEALDV--TLSSPFLFAIYEQDSGTLHFL 443 Query: 491 GRVANP 496 GRV NP Sbjct: 444 GRVNNP 449 >2WXZ-C nrPDB Length = 453 Score = 68.2 bits (165), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 56/245 (22%), Positives = 107/245 (43%), Gaps = 6/245 (2%) Query: 254 SDPAFIS-KTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHN 312 +DP + K N + +T + LE + + + ++F+G + F ++T H Sbjct: 209 TDPVLAAQKINRFVQAVTGWKMNLPLEGVSTDSTLFFNTYVHFQGK-MRGF-SQLTGLHE 266 Query: 313 FRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQ 372 F ++ V V M+ GNF +D + + + ++ +++L++ P S + +E Sbjct: 267 FWVDNSTSVSVPMLSGTGNFQHWSDAQNNFSVTRVPLGESVTLLLIQPQCASDLDRVEVL 326 Query: 373 LTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRI 432 + W K+ R + LP+ ++ +YNL + L + L N+ + D Sbjct: 327 VFQHDFLTWIKNPPPRAIRLTLPQLEIRGSYNLQDLLAQAKLSTLLGAEANLGKMGDTNP 386 Query: 433 AIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQV-RFTVDRPFLFLIYEHRTSCLLFMG 491 + + +I + + + T P S +V T+ PFLF IYE + L F+G Sbjct: 387 RVG--EVLNSILLELQAGEEEQPTESAQQPGSPEVLDVTLSSPFLFAIYERDSGALHFLG 444 Query: 492 RVANP 496 RV NP Sbjct: 445 RVDNP 449 >6BJ5-B nrPDB Length = 315 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 65/328 (19%), Positives = 138/328 (42%), Gaps = 56/328 (17%) Query: 146 NTFDNIFIAPVGISTAMGMISLGLKGETHEQV---HSILHFKDFVNASSKYEITTIHNLF 202 N DN+ +P G+++A+ ++ + G T ++ S++ D Sbjct: 28 NESDNVVFSPYGLTSALSVLRIAAGGNTKREIDVPESVVEDSD----------------- 70 Query: 203 RKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKT 262 ++ +L++ P+ +F + + Q F+ Sbjct: 71 --------------AFLALRELFVDASVPLRPEFTAEFSSRFNTSVQRVTFNSENVKDVI 116 Query: 263 NNHIMKLTKGLIKDALE-NIDPATQMMILNCIYFKGSWVNKFPVEMT-----HNHNFRLN 316 N+++ T G + L+ ++D T+M++L+ + K SW + F T ++ N Sbjct: 117 NSYVKDKTGGDVPRVLDASLDRDTKMLLLSSVRMKTSWRHVFDPSFTTDQPFYSGNVTYK 176 Query: 317 EREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-GISMLIVVPHKMSGM-KTLEAQLT 374 R + K+ ++T+ L + + + +L Y +ML+VVP + + + L+ L Sbjct: 177 VRMMNKIDTLKTETFTL----RNVGYSVTELPYKRRQTAMLLVVPDDLGEIVRALDLSL- 231 Query: 375 PRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKN----GNMAGISDQ 430 V W ++M +V++PKF +E +L ++L+ +G+R FD + G + +D Sbjct: 232 ---VRFWIRNMRKDVCQVVMPKFSVESVLDLRDALQRLGVRDAFDPSRADFGQASPSNDL 288 Query: 431 RIAIDLFKHQGTITVNEEGTQATTVTTV 458 + L I +E GT A++ T + Sbjct: 289 YVTKVL--QTSKIEADERGTTASSDTAI 314 >5C98-A nrPDB Length = 382 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 38/202 (18%), Positives = 87/202 (43%), Gaps = 7/202 (3%) Query: 280 NIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQE 339 ++ P ++M+ + + +F T F+ +VS M T E Sbjct: 162 SLPPCHKLMLFSGVSVLTPLAIRFNPADTALELFQFINAPTQRVSTMHTTAFVRRCLHNE 221 Query: 340 LDCDILQLEY--VGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKF 397 L C ++ + + G+SML+++P+ + ++ + +TP + + + + + ++ LPKF Sbjct: 222 LRCKVVDMPFDAASGLSMLVLLPYDGTELRQIVNSITPAHLAQIDERLQSCWTDLKLPKF 281 Query: 398 KLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTT 457 + + + ++L +G +F+ + R ++ F + V+E G+ Sbjct: 282 FVREKTDPKQTLGKLGYGGVFEIDDLHVFHDSGRTRLNGFIQHCYLAVSESGSGIPAPPD 341 Query: 458 VGFMPLSTQVRFTVDRPFLFLI 479 ++ F +RPF+FLI Sbjct: 342 T-----PSEFEFHANRPFMFLI 358 >1Z1W-A nrPDB Length = 780 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 36/162 (22%), Positives = 71/162 (43%), Gaps = 21/162 (12%) Query: 126 LNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKD 185 L + +K+ ++ R V ++N F P + M +IS+ G + + F++ Sbjct: 187 LKDIRSKYPLDMAR---KSVEFYENYFGIPYALPK-MHLISVPEFGAGAMENWGAITFRE 242 Query: 186 -FVNASSKYEITTIHNLFRKLTHRLFRRNFG--YTLRSVNDLYIQKQFPILLDFKTKVRE 242 +++ + +T N + H + + FG T++ NDL++ + F + +KT + Sbjct: 243 IYMDIAENSAVTVKRNSANVIAHEIAHQWFGDLVTMKWWNDLWLNESFATFMSYKTM--D 300 Query: 243 YYFAEAQI-ADFSDPAFISKTNNHIMKLTKGLIKDALENIDP 283 F E DF F+S+T+ L D+L+N P Sbjct: 301 TLFPEWSFWGDF----FVSRTSG-------ALRSDSLKNTHP 331 >5EUL-Y nrPDB Length = 424 Score = 28.9 bits (63), Expect = 5.5, Method: Compositional matrix adjust. Identities = 14/27 (51%), Positives = 18/27 (66%) Query: 350 VGGISMLIVVPHKMSGMKTLEAQLTPR 376 +GG S+LIVV + MK LE+QL R Sbjct: 391 IGGTSLLIVVGVALETMKQLESQLVKR 417 >4RNY-A nrPDB Length = 371 Score = 28.5 bits (62), Expect = 7.7, Method: Compositional matrix adjust. Identities = 28/124 (22%), Positives = 53/124 (42%), Gaps = 11/124 (8%) Query: 216 YTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIK 275 YTLR N+ IQ PI D + + Y E DF F K ++ L + Sbjct: 46 YTLRDANNTLIQALIPISQDLQIHI--YKKGEDYFLDFIPIIFTRKEKTLLLSLQTSPYQ 103 Query: 276 DALENI-DPATQMMILNC----IYFKGSWVNKFPVEMTHNHNFRLNE---REVVKVSMMQ 327 D ++ DP ++N + FK V + + + ++R+ + + +K++M+ Sbjct: 104 DIIKATNDPLLANQLMNAYKKSVPFK-RLVKNDKIAIVYTRDYRVGQAFGQPTIKMAMVS 162 Query: 328 TKGN 331 ++ N Sbjct: 163 SRSN 166 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1JMJ-A nrPDB 695 0.0 6EE5-A nrPDB 547 e-156 3NE4-A nrPDB 440 e-124 2VDY-A nrPDB 435 e-122 6HGE-B nrPDB 430 e-121 2OL2-A nrPDB 424 e-119 5HGC-A nrPDB 423 e-119 1BY7-A nrPDB 421 e-118 4EB1-I nrPDB 413 e-116 1ATT-A nrPDB 412 e-115 1YXA-A nrPDB 406 e-113 4AJT-A nrPDB 402 e-112 4ZK0-A nrPDB 398 e-111 4Y40-A nrPDB 398 e-111 4GA7-A nrPDB 396 e-111 6F02-A nrPDB 395 e-110 3DY0-A nrPDB 392 e-109 5NCS-A nrPDB 390 e-109 3NDA-A nrPDB 390 e-109 1UHG-A nrPDB 388 e-108 2XN5-A nrPDB 384 e-107 1QMB-A nrPDB 377 e-105 1C5G-A nrPDB 377 e-105 2V95-A nrPDB 376 e-104 2H4P-A nrPDB 369 e-102 4P0F-A nrPDB 368 e-102 2H4Q-A nrPDB 368 e-102 4KDS-A nrPDB 366 e-102 5INW-A nrPDB 365 e-101 3LW2-A nrPDB 365 e-101 4DY0-A nrPDB 365 e-101 1HLE-A nrPDB 364 e-101 4AJU-A nrPDB 359 1e-99 6F4U-A nrPDB 358 3e-99 4DTE-A nrPDB 349 2e-96 5NCU-A nrPDB 349 2e-96 2R9Y-A nrPDB 346 2e-95 3F02-A nrPDB 344 6e-95 1IMV-A nrPDB 338 3e-93 3ZHA-A nrPDB 331 5e-91 1XQJ-A nrPDB 329 2e-90 3LE2-A nrPDB 326 2e-89 3PZF-A nrPDB 320 7e-88 3OZQ-A nrPDB 313 9e-86 1K9O-I nrPDB 313 2e-85 6CJ7-A nrPDB 311 3e-85 3STO-A nrPDB 309 1e-84 2PEF-A nrPDB 305 3e-83 1SEK-A nrPDB 300 1e-81 2OAY-A nrPDB 294 5e-80 1C8O-A nrPDB 292 3e-79 1JJO-C nrPDB 276 1e-74 1SNG-A nrPDB 274 5e-74 1M93-B nrPDB 253 1e-67 2WXZ-C nrPDB 246 2e-65 1MTP-A nrPDB 243 2e-64 2WXX-A nrPDB 241 6e-64 6BJ5-B nrPDB 239 2e-63 5M3Y-A nrPDB 231 4e-61 5C98-A nrPDB 209 3e-54 Sequences not found previously or not previously below threshold: 4R9I-A nrPDB 91 1e-18 4I9T-A nrPDB 34 0.14 4P2L-A nrPDB 32 0.65 5W76-A nrPDB 32 0.78 4OVR-A nrPDB 31 0.94 5NSQ-A nrPDB 30 2.3 3T59-A nrPDB 30 2.3 3H1Q-A nrPDB 30 2.8 2ILV-A nrPDB 29 4.1 5L7Z-A nrPDB 29 4.3 5T7V-LC nrPDB 29 5.2 2P6F-A nrPDB 28 7.2 4YUX-A nrPDB 28 8.7 >1JMJ-A nrPDB Length = 480 Score = 695 bits (1793), Expect = 0.0, Method: Composition-based stats. Identities = 480/480 (100%), Positives = 480/480 (100%) Query: 20 GSKGPLDQLEKGGETAQSADPQWEQLNNKNLSMPLLPADFHKENTVTNDWIPEGEEDDDY 79 GSKGPLDQLEKGGETAQSADPQWEQLNNKNLSMPLLPADFHKENTVTNDWIPEGEEDDDY Sbjct: 1 GSKGPLDQLEKGGETAQSADPQWEQLNNKNLSMPLLPADFHKENTVTNDWIPEGEEDDDY 60 Query: 80 LDLEKIFSEDDDYIDIVDSLSVSPTDSDVSAGNILQLFHGKSRIQRLNILNAKFAFNLYR 139 LDLEKIFSEDDDYIDIVDSLSVSPTDSDVSAGNILQLFHGKSRIQRLNILNAKFAFNLYR Sbjct: 61 LDLEKIFSEDDDYIDIVDSLSVSPTDSDVSAGNILQLFHGKSRIQRLNILNAKFAFNLYR 120 Query: 140 VLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIH 199 VLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIH Sbjct: 121 VLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIH 180 Query: 200 NLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFI 259 NLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFI Sbjct: 181 NLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFI 240 Query: 260 SKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNERE 319 SKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNERE Sbjct: 241 SKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNERE 300 Query: 320 VVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVE 379 VVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVE Sbjct: 301 VVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVE 360 Query: 380 RWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKH 439 RWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKH Sbjct: 361 RWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKH 420 Query: 440 QGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPSRS 499 QGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPSRS Sbjct: 421 QGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPSRS 480 >6EE5-A nrPDB Length = 379 Score = 547 bits (1409), Expect = e-156, Method: Composition-based stats. Identities = 149/380 (39%), Positives = 216/380 (56%), Gaps = 12/380 (3%) Query: 117 FHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQ 176 F G + +L N FAF+LYR L + NIF +PV IS+A+ M+SLG KG+TH Q Sbjct: 12 FQGAASSHKLAEANTDFAFSLYRELAKS-SPDKNIFFSPVSISSALAMLSLGAKGDTHTQ 70 Query: 177 VHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDF 236 + L F IH F+ L L R G L++ N L++ K +L F Sbjct: 71 ILEGLGFNSE---------ADIHQGFQHLLQTLNRPK-GLQLKTANGLFVDKSLKLLDSF 120 Query: 237 KTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFK 296 ++ Y AEA DF + N+ + K T G IKD L+++D T ++++N IYFK Sbjct: 121 LEDSKKLYQAEAFSVDFDPEEAKKQINDWVEKQTNGKIKDLLKDLDSDTVLVLVNAIYFK 180 Query: 297 GSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISML 356 G W F E T +F ++E+ VKV MM KG F +D EL C +L+L Y G SML Sbjct: 181 GKWKKPFDPENTKEEDFHVDEKTTVKVPMMSQKGKFYYYHDDELSCKVLELPYKGNASML 240 Query: 357 IVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRM 416 I++P + G++ LE LTP + +W KS+T R+ E+ LPKFK+E Y+L E L +GI Sbjct: 241 IILPDE-GGLQHLEQSLTPETLSKWLKSLTRRSVELYLPKFKIEGTYDLKEVLSNLGITD 299 Query: 417 LFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFL 476 LF +++GI+++++ + H+ + VNEEGT+A T + +P+S F DRPFL Sbjct: 300 LFSPGADLSGITEEKLYVSKAVHKAVLEVNEEGTEAAAATFLEAIPMSIPPEFKADRPFL 359 Query: 477 FLIYEHRTSCLLFMGRVANP 496 FLI E++T +LFMG+V NP Sbjct: 360 FLIRENKTGSILFMGKVVNP 379 >3NE4-A nrPDB Length = 424 Score = 440 bits (1132), Expect = e-124, Method: Composition-based stats. Identities = 109/377 (28%), Positives = 204/377 (54%), Gaps = 9/377 (2%) Query: 124 QRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHF 183 ++ A+FAF+LYR L Q N NIF +PV I+TA M+SLG K +TH+++ L+F Sbjct: 54 NKITPNLAEFAFSLYRQLAHQSN-STNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNF 112 Query: 184 KDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREY 243 ++ IH F++L L + + L + N L++ + ++ F V++ Sbjct: 113 N-----LTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKL 167 Query: 244 YFAEAQIADFSDPAFISK-TNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNK 302 Y +EA +F D K N+++ K T+G I D ++ +D T ++N I+FKG W Sbjct: 168 YHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERP 227 Query: 303 FPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHK 362 F V+ T +F +++ VKV MM+ G F + ++L +L ++Y+G + + +P + Sbjct: 228 FEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDE 287 Query: 363 MSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNG 422 ++ LE +LT ++ ++ ++ R+ + LPK + Y+L L +GI +F Sbjct: 288 -GKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGA 346 Query: 423 NMAGISDQ-RIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYE 481 +++G++++ + + H+ +T++E+GT+A + +P+S ++PF+FL+ E Sbjct: 347 DLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPEVKFNKPFVFLMIE 406 Query: 482 HRTSCLLFMGRVANPSR 498 T LFMG+V NP++ Sbjct: 407 QNTKSPLFMGKVVNPTQ 423 >2VDY-A nrPDB Length = 373 Score = 435 bits (1118), Expect = e-122, Method: Composition-based stats. Identities = 114/373 (30%), Positives = 189/373 (50%), Gaps = 9/373 (2%) Query: 126 LNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKD 185 L N FAF+LY+ L ++ NIFI+PV IS A+ M+SLG G T Q+ L F Sbjct: 7 LASANVDFAFSLYKHLV-ALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNL 65 Query: 186 FVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYF 245 + ++ IH F+ L + + + N L++ +L F ++ YY Sbjct: 66 TERSETE-----IHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYE 120 Query: 246 AEAQIADFSDPAFISK-TNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFP 304 +E +F D A S+ N+++ T+G I D +D ++++N I+FKG+W F Sbjct: 121 SEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFD 180 Query: 305 VEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMS 364 + T NF ++E VVKV MM +D EL C ++Q+ YVG ++ ++P K Sbjct: 181 LASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGNGTVFFILPDK-G 239 Query: 365 GMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNM 424 M T+ A L+ + RW +T+ ++ +PK + Y+L + L+ MGI LF N Sbjct: 240 KMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTTQANF 299 Query: 425 AGIS-DQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHR 483 + I+ D ++ H+ + +NEEGT+A + +P S + ++PF+ +I++H Sbjct: 300 SRITQDAQLKSSKVVHKAVLQLNEEGTEAAGAMFLEAIPRSKPIILRFNQPFIIMIFDHF 359 Query: 484 TSCLLFMGRVANP 496 T LF+ RV NP Sbjct: 360 TWSSLFLARVMNP 372 >6HGE-B nrPDB Length = 409 Score = 430 bits (1106), Expect = e-121, Method: Composition-based stats. Identities = 124/408 (30%), Positives = 202/408 (49%), Gaps = 21/408 (5%) Query: 102 SPTDSDVSAGNILQLFH--GKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGIS 159 SP D + N+ Q G + L N FAF+LY+ L + N+ +P+ IS Sbjct: 13 SPLDEE----NLTQENQDRGTHVDRGLASANVDFAFSLYKQLVLKA-PDKNVIFSPLSIS 67 Query: 160 TAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLR 219 TA+ +SLG T ++ L F ++ IH F+ L L + + L Sbjct: 68 TALAFLSLGAHNTTLTEILKGLKFN-----LTETSEAEIHQSFQHLLRTLNQSSDELQLS 122 Query: 220 SVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISK-TNNHIMKLTKGLIKDAL 278 N +++++Q +L F + Y +EA DF D A K N+++ T+G I D + Sbjct: 123 MGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLI 182 Query: 279 ENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKG-NFLAAND 337 +++D T M+++N I+FK W F + TH F L++++ V V MM D Sbjct: 183 KDLDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMVPMMSLHHLTIPYFRD 242 Query: 338 QELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTR-EVLLPK 396 +EL C ++QL Y G S L ++P + M+ +EA L+ + RW S+ R E+ LPK Sbjct: 243 EELSCTVVQLNYTGNASALFILPDQ-DKMEEVEAMLSRETLNRWGDSLEFREIGELYLPK 301 Query: 397 FKLEKNYNLVESLKLMGIRMLFDKNGNMAGISD-QRIAIDLFKHQGTITVNEEGTQATTV 455 F + ++YNL + L +GI F +++GI+ + +A+ H+ + V EEGT+A+ Sbjct: 302 FSISRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQVVHKAVLDVFEEGTEASAA 361 Query: 456 TTVGFMPLSTQVR----FTVDRPFLFLIYEHRTSCLLFMGRVANPSRS 499 T V LS V +RPFL +I +H T + FM +V NP ++ Sbjct: 362 TAVKITLLSALVETRTIVRFNRPFLMIIVDHFTWSIFFMSKVTNPKQA 409 >2OL2-A nrPDB Length = 395 Score = 424 bits (1090), Expect = e-119, Method: Composition-based stats. Identities = 107/370 (28%), Positives = 180/370 (48%), Gaps = 15/370 (4%) Query: 132 KFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASS 191 F F+LYR L NIF +PV IS ++ M+SLG T Q+ L Sbjct: 36 DFTFDLYRALASAA-PSQNIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLN-----LQ 89 Query: 192 KYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIA 251 K +H F++L L + G+ L N L+ + F + ++ Y A+ Sbjct: 90 KSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPT 149 Query: 252 DFSDPAFI-SKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHN 310 +F D A + N+++ K TKG I D L+N+D ++++N I+FK W F + T Sbjct: 150 NFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQE 209 Query: 311 HNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLE 370 +F + VV+V MM + + D+ L C ++ + Y G + L ++P + M+ +E Sbjct: 210 QDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSE-GKMQQVE 268 Query: 371 AQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQ 430 L+ + + +W K R E+ LPKF +E +Y L + L +GI +F + +++GIS+ Sbjct: 269 NGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNH 328 Query: 431 -RIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQV---RFTVDRPFLFLIYEHRTSC 486 I + H+ + V+E GT+A T F S ++ R +RPFL I ++ Sbjct: 329 SNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNN--- 385 Query: 487 LLFMGRVANP 496 +LF+G+V P Sbjct: 386 ILFLGKVNRP 395 >5HGC-A nrPDB Length = 380 Score = 423 bits (1089), Expect = e-119, Method: Composition-based stats. Identities = 117/375 (31%), Positives = 188/375 (50%), Gaps = 9/375 (2%) Query: 125 RLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFK 184 +L NA FAF +R + + NIF +PV ISTA M++LG + T Q+ L F Sbjct: 10 KLVPNNADFAFQFFREVTQEA-PNKNIFYSPVSISTAFAMLALGARSATQSQILEGLAFN 68 Query: 185 DFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYY 244 ++ + IH F L H L G L +N +++ +L F + Y Sbjct: 69 -----LTEIQEKEIHEGFHNLIHMLNHPEGGVQLNMMNAIFVTAALALLRKFLDDAKALY 123 Query: 245 FAEAQIADFSDPAFISK-TNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKF 303 EA DF+ P K N++I + T G I + ++++DP T M++ + +YFKGSW F Sbjct: 124 QLEAFTTDFNKPTEAEKQINDYIERKTHGKITNLVKDMDPQTVMLLASFVYFKGSWEKPF 183 Query: 304 PVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKM 363 E T F ++ VKV MM G F D+EL C +++L Y G + +V+P K Sbjct: 184 EAEHTEEREFFVDAETTVKVPMMYQMGRFDFYFDEELSCTVVRLHYNGSATAFLVLPAK- 242 Query: 364 SGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGN 423 MK LE L +++W + R + PKF + +Y + +L+ MGI +F + Sbjct: 243 GKMKQLEQTLDKETIQKWSDHLFQRFMNLYFPKFSISGSYEISNTLRKMGIVDVFTNQAD 302 Query: 424 MAGISDQR-IAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEH 482 ++GI+ + + H+ ++ V+E+GT+A T V MP+S PFL LI++ Sbjct: 303 LSGITGSPDLKVSKVVHKASLDVDEKGTEAAAATAVEIMPISFPPTIEFSHPFLMLIFDR 362 Query: 483 RTSCLLFMGRVANPS 497 T+ LF+G++ NP+ Sbjct: 363 DTNSTLFIGKIVNPT 377 >1BY7-A nrPDB Length = 382 Score = 421 bits (1082), Expect = e-118, Method: Composition-based stats. Identities = 121/388 (31%), Positives = 207/388 (53%), Gaps = 20/388 (5%) Query: 123 IQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILH 182 ++ L + N FA NL++ L + + N+F++P IS+ M M+ +G +G T +Q+ +L Sbjct: 1 MEDLCVANTLFALNLFKHLA-KASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQ 59 Query: 183 FKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVRE 242 F + A+ K IH+ FR L+ + Y L SVN L+ +K ++ ++ Sbjct: 60 FNEVGAAADK-----IHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQK 114 Query: 243 YYFAEAQIADFSDPAFIS--KTNNHIMKLTKGLIKDALE--NIDPATQMMILNCIYFKGS 298 YY +E Q DF + A + K N+ + TKG I + L ++D T+M+++N +YFKG Sbjct: 115 YYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGK 174 Query: 299 WVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIV 358 W F ++ + FR+N + V MM + ++L IL+L Y G +SM ++ Sbjct: 175 WKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLL 234 Query: 359 VPHKM----SGMKTLEAQLTPRVVERW--QKSMTNRTREVLLPKFKLEKNYNLVESLKLM 412 +P ++ +G++ LE+++T + +W + M EV +P+FKLE++Y L L+ M Sbjct: 235 LPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSM 294 Query: 413 GIRMLFDKN-GNMAGISDQR-IAIDLFKHQGTITVNEEGTQATTVTTVGFMPLS--TQVR 468 G+ F+K N +G+S++ + + HQ + VNEEGT+A T + + Sbjct: 295 GMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGPQ 354 Query: 469 FTVDRPFLFLIYEHRTSCLLFMGRVANP 496 F D PFLFLI T+C+LF GR ++P Sbjct: 355 FVADHPFLFLIMHKITNCILFFGRFSSP 382 >4EB1-I nrPDB Length = 440 Score = 413 bits (1063), Expect = e-116, Method: Composition-based stats. Identities = 121/397 (30%), Positives = 188/397 (47%), Gaps = 26/397 (6%) Query: 122 RIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSIL 181 R+ L+ N++FA Y+ L D N DNIF++P+ ISTA M LG +T +Q+ + Sbjct: 47 RVWELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVF 106 Query: 182 HFKDFVNASSKYEITTIHNLFRKLTHRLF-RRNFGYTLRSVNDLYIQKQFPILLDFKTKV 240 F +S IH F KL RL+ + N L S N L+ K ++ Sbjct: 107 KFDTISEKTSD----QIHFFFAKLNCRLYRKANKASKLVSANRLFGDKSLTFNETYQDIS 162 Query: 241 REYYFAEAQIADFSDPAFISK--TNNHIMKLTKGLIKDALEN----------IDPATQMM 288 Y A+ Q DF + A S+ N + T+G I D + + +T ++ Sbjct: 163 ELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINVLVLVNTRTSTVLV 222 Query: 289 ILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLE 348 ++N IYFKG W +KF E T F + E SMM +G F E +L+L Sbjct: 223 LVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAE-GTQVLELP 281 Query: 349 YVG-GISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVE 407 + G I+M++++P + +E +LTP V++ W + V +P+F++E ++L E Sbjct: 282 FKGDDITMVLILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKE 341 Query: 408 SLKLMGIRMLFDKN-GNMAGI---SDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPL 463 L+ MG+ LF + GI + + H+ + VNEEG++A T V Sbjct: 342 QLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGR 401 Query: 464 ST---QVRFTVDRPFLFLIYEHRTSCLLFMGRVANPS 497 S +V F +RPFL I E + ++FMGRVANP Sbjct: 402 SLNPNRVTFKANRPFLVFIREVPLNTIIFMGRVANPC 438 >1ATT-A nrPDB Length = 429 Score = 412 bits (1060), Expect = e-115, Method: Composition-based stats. Identities = 121/389 (31%), Positives = 186/389 (47%), Gaps = 18/389 (4%) Query: 122 RIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSIL 181 R+ L+ N+ FA Y+ L D N DNIF++P+ ISTA M LG T Q+ + Sbjct: 44 RVWELSKANSHFATAFYQHLADSKNNNDNIFLSPLSISTAFAMTKLGACNNTLTQLMEVF 103 Query: 182 HFKDFVNASSKYEITTIHNLFRKLTHRLF-RRNFGYTLRSVNDLYIQKQFPILLDFKTKV 240 F +S IH F KL RL+ + N L S N L+ K ++ Sbjct: 104 KFDTISEKTSD----QIHFFFAKLNCRLYRKANKSSELVSANRLFGDKSITFNETYQDIS 159 Query: 241 REYYFAEAQIADFSDPAFISK--TNNHIMKLTKGLIKDALEN--IDPATQMMILNCIYFK 296 Y A+ Q DF A S+ N I T+G I D + I+ T ++++N IYFK Sbjct: 160 EVVYGAKLQPLDFKGNAEQSRLTINQWISNKTEGRITDVIPPQAINEFTVLVLVNTIYFK 219 Query: 297 GSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-GISM 355 G W +KF E T F + E V MM + F E +L+L + G I+M Sbjct: 220 GLWKSKFSPENTRKELFYKADGESCSVLMMYQESKFRYRRVAE-STQVLELPFKGDDITM 278 Query: 356 LIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIR 415 ++++P + +E +LTP +++ W +T V +P+F++E ++++ E L+ MG+ Sbjct: 279 VLILPKLEKTLAKVEQELTPDMLQEWLDELTETLLVVHMPRFRIEDSFSVKEQLQDMGLE 338 Query: 416 MLFDKN-GNMAGI---SDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLST---QVR 468 LF + GI + + H+ + VNEEG++A T + S +V Sbjct: 339 DLFSPEKSRLPGIVAEGRSDLYVSDAFHKAFLEVNEEGSEAAASTVISIAGRSLNSDRVT 398 Query: 469 FTVDRPFLFLIYEHRTSCLLFMGRVANPS 497 F +RPFL LI E + ++FMGRVANP Sbjct: 399 FKANRPFLVLIREVALNTIIFMGRVANPC 427 >1YXA-A nrPDB Length = 398 Score = 406 bits (1043), Expect = e-113, Method: Composition-based stats. Identities = 121/379 (31%), Positives = 199/379 (52%), Gaps = 14/379 (3%) Query: 126 LNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKD 185 L +N FAF+LY+ L + N NI +P+ IS A+ ++SLG KG T E++ L F Sbjct: 27 LASINTDFAFSLYKELVLK-NPDTNIVFSPLSISAALALVSLGAKGNTLEEILEGLKFN- 84 Query: 186 FVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYF 245 ++ IH F L RL + + + + L+I+K+ IL +F+ K + Y Sbjct: 85 ----LTETSEADIHQGFGHLLQRLNQPKDQVQISTGSALFIEKRQQILTEFQEKAKTLYQ 140 Query: 246 AEAQIADFSDPAFISK-TNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFP 304 AEA ADF P K N+++ K T+G+IK+ + ++D T M+++N IYFK W F Sbjct: 141 AEAFTADFQQPRQAKKLINDYVRKQTQGMIKELVSDLDKRTLMVLVNYIYFKAKWKVPFD 200 Query: 305 VEMTHNHNFRLNEREVVKVSMMQTKG-NFLAANDQELDCDILQLEYVGGISMLIVVPHKM 363 T F +R V V MM + D+EL C +++L+Y G S L ++P + Sbjct: 201 PLDTFKSEFYCGKRRPVIVPMMSMEDLTTPYFRDEELSCTVVELKYTGNASALFILPDQ- 259 Query: 364 SGMKTLEAQLTPRVVERWQKSMTNRTR-EVLLPKFKLEKNYNLVESLKLMGIRMLFDKNG 422 M+ +EA L P + +W+ S+ R E+ LPKF + +Y+L + L +GIR +F Sbjct: 260 GRMQQVEASLQPETLRKWKNSLKPRMIDELHLPKFSISTDYSLEDVLSKLGIREVFSTQA 319 Query: 423 NMAGISDQR-IAIDLFKHQGTITVNEEGTQATTVTTVGFMPLST---QVRFTVDRPFLFL 478 +++ I+ + + + H+ + V E GT+A T V F+P+S + +RPFL + Sbjct: 320 DLSAITGTKDLRVSQVVHKAVLDVAETGTEAAAATGVKFVPMSAKLYPLTVYFNRPFLIM 379 Query: 479 IYEHRTSCLLFMGRVANPS 497 I++ T F+ ++ANP Sbjct: 380 IFDTETEIAPFIAKIANPK 398 >4AJT-A nrPDB Length = 427 Score = 402 bits (1032), Expect = e-112, Method: Composition-based stats. Identities = 124/378 (32%), Positives = 194/378 (51%), Gaps = 10/378 (2%) Query: 123 IQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILH 182 Q+L+ + F FNL R K + N+ +P G+S AM + LG KGET Q+ + L+ Sbjct: 55 SQQLSNETSSFGFNLLR--KISMRHDGNVIFSPFGLSVAMVNLMLGTKGETKVQIENGLN 112 Query: 183 FKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVRE 242 A S+ + LF+K+ F N L + +I K F I + ++ Sbjct: 113 L----QALSQAGPLILPALFKKVKET-FSSNRDLGLSQGSFAFIHKDFDIKETYFNLSKK 167 Query: 243 YYFAEAQIADFSDPAFISKTNNH-IMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVN 301 Y+ E +F + + NH I+K T+G I + I+P T++++++ + FKG W+ Sbjct: 168 YFDIEYVSINFQNSSQARGLINHCIVKETEGKIPKLFDEINPETKLILVDYVLFKGKWLT 227 Query: 302 KFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPH 361 F T F L++ +KV MM +GNF + D++ C IL+L Y G +ML+V+ Sbjct: 228 PFDPSFTEADTFHLDKYRAIKVPMMYREGNFTSTFDKKFRCHILKLPYQGNATMLVVLME 287 Query: 362 KMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKN 421 K LE LT +VE W ++M R EV PKFKL + Y + E LK MGIR LF + Sbjct: 288 KTGDYLALEDYLTVDLVETWLQNMKTRKMEVFFPKFKLNQRYEMHELLKQMGIRRLFSTS 347 Query: 422 GNMAGIS--DQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLI 479 +++ +S + + + Q + V+E GT+A + T + S V+RPF F+I Sbjct: 348 ADLSELSAMARNLQVSRVLQQSVLEVDERGTEAVSGTLSEIIAYSMPPAIKVNRPFHFII 407 Query: 480 YEHRTSCLLFMGRVANPS 497 YE + LLF+GRV NP+ Sbjct: 408 YEEMSRMLLFLGRVVNPT 425 >4ZK0-A nrPDB Length = 390 Score = 398 bits (1024), Expect = e-111, Method: Composition-based stats. Identities = 108/392 (27%), Positives = 206/392 (52%), Gaps = 20/392 (5%) Query: 123 IQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILH 182 + L+ N KF F+L++ + NIF +P+ I++A+GM+ LG K T +Q+ +LH Sbjct: 1 MNSLSEANTKFMFDLFQQFRKSKEN--NIFYSPISITSALGMVLLGAKDNTAQQIKKVLH 58 Query: 183 FKDFVNASSKYEITT-------IHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLD 235 F ++ T +H+ F+KL + Y L+ N L+ +K + L + Sbjct: 59 FDQVTENTTGKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQE 118 Query: 236 FKTKVREYYFAEAQIADFSDPAFIS--KTNNHIMKLTKGLIKDALEN--IDPATQMMILN 291 + ++++Y + DF++ S K N+ + T IK+ + I T ++++N Sbjct: 119 YLDAIKKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVN 178 Query: 292 CIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG 351 IYFKG W KF E T F N+ + MM+ +F A+ +++ +L++ Y G Sbjct: 179 AIYFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTSFHFASLEDVQAKVLEIPYKG 238 Query: 352 -GISMLIVVPHKMSGMKTLEAQLTPRVVERW--QKSMTNRTREVLLPKFKLEKNYNLVES 408 +SM++++P+++ G++ LE +LT + W ++M ++ LP+FK+E++Y+L ++ Sbjct: 239 KDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDT 298 Query: 409 LKLMGIRMLFDKNGNMAGISDQR-IAIDLFKHQGTI---TVNEEGTQATTVTTVGFMPLS 464 L+ MG+ +F+ + +++G++ R + + H+ + E AT V G P S Sbjct: 299 LRTMGMVDIFNGDADLSGMTGSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFGSSPTS 358 Query: 465 TQVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496 T F + PFLF I +++T+ +LF GR ++P Sbjct: 359 TNEEFHCNHPFLFFIRQNKTNSILFYGRFSSP 390 >4Y40-A nrPDB Length = 414 Score = 398 bits (1023), Expect = e-111, Method: Composition-based stats. Identities = 102/374 (27%), Positives = 185/374 (49%), Gaps = 11/374 (2%) Query: 125 RLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFK 184 L N F L + L N NIF++P+ ISTA M+ LG + T +++ +F+ Sbjct: 47 ELARQNMDLGFKLLKKLAF-YNPGRNIFLSPLSISTAFSMLCLGAQDSTLDEIKQGFNFR 105 Query: 185 DFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYY 244 K +H F + H L ++ L N L+I ++ F + +Y Sbjct: 106 -------KMPEKDLHEGFHYIIHELTQKTQDLKLSIGNTLFIDQRLQPQRKFLEDAKNFY 158 Query: 245 FAEAQIADFSDPAFISK-TNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKF 303 AE + +F + K N+ I + T G I + +ENIDP T M++ N I+F+ W ++F Sbjct: 159 SAETILTNFQNLEMAQKQINDFISQKTHGKINNLIENIDPGTVMLLANYIFFRARWKHEF 218 Query: 304 PVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKM 363 +T +F L + VKV MM G + D +L C IL++ Y I+ + ++P + Sbjct: 219 DPNVTKEEDFFLEKNSSVKVPMMFRSGIYQVGYDDKLSCTILEIPYQKNITAIFILPDE- 277 Query: 364 SGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGN 423 +K LE L RW+ ++ R V +P+ + ++L ++L +G+ +F+++G+ Sbjct: 278 GKLKHLEKGLQVDTFSRWKTLLSRRVVCVSVPRLHMTGTFDLKKTLSYIGVSKIFEEHGD 337 Query: 424 MAGISDQR-IAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEH 482 + I+ R + + H+ + ++E GT+ T +P+ T + +D+P+L LIY Sbjct: 338 LTKIAPHRSLKVGEAVHKAELKMDERGTEGAAGTGAQTLPMETPLCVKIDKPYLLLIYSE 397 Query: 483 RTSCLLFMGRVANP 496 + +LF+G++ NP Sbjct: 398 KIPSVLFLGKIVNP 411 >4GA7-A nrPDB Length = 389 Score = 396 bits (1018), Expect = e-111, Method: Composition-based stats. Identities = 124/391 (31%), Positives = 202/391 (51%), Gaps = 25/391 (6%) Query: 121 SRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSI 180 S +++L+ N +FA +L+ L + N NIFI+P IS+AM M+ LG +G T Q+ Sbjct: 9 SGMEQLSSANTRFALDLFLALSEN-NPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKT 67 Query: 181 LHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKV 240 HF + +H+ F+ L + +R Y L+ N LY +K + L +F Sbjct: 68 FHFNT---------VEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVST 118 Query: 241 REYYFAEAQIADFSDPAFISK--TNNHIMKLTKGLIKDALEN--IDPATQMMILNCIYFK 296 ++ Y A+ DF + ++ N + T+G I + L + +D T+++++N IYFK Sbjct: 119 QKTYGADLASVDFQHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFK 178 Query: 297 GSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-GISM 355 G+W +KF E T N FRLN+++ V MM K F ++L C +L+L Y G +SM Sbjct: 179 GNWKDKFMKEATTNAPFRLNKKDRKTVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSM 238 Query: 356 LIVVPHKM----SGMKTLEAQLTPRVVERWQK--SMTNRTREVLLPKFKLEKNYNLVESL 409 +I++P + +G+K +E QLT + W K ++ V LP+FKLE++Y L L Sbjct: 239 VILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDL 298 Query: 410 KLMGIRMLF-DKNGNMAGISDQR-IAIDLFKHQGTITVN--EEGTQATTVTTVGFMPLST 465 +G++ LF +++G+S R I I H+ + VN A T F Sbjct: 299 ARLGVQDLFNSSKADLSGMSGARDIFISKIVHKSFVEVNEEGTEAAAATAGIATFCMDDP 358 Query: 466 QVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496 + FT D PFLF I + + +LF+GR ++P Sbjct: 359 EENFTADHPFLFFIRHNSSGSILFLGRFSSP 389 >6F02-A nrPDB Length = 389 Score = 395 bits (1014), Expect = e-110, Method: Composition-based stats. Identities = 109/388 (28%), Positives = 185/388 (47%), Gaps = 17/388 (4%) Query: 121 SRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSI 180 S ++ NA FAF Y ++ + NIF +P+ IS A M+SLG + Q+ Sbjct: 2 SPSLKIAPANADFAFRFYYLIASET-PGKNIFFSPLSISAAYAMLSLGACSHSRSQILEG 60 Query: 181 LHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKV 240 L F ++ + +H F+ L H L G R + L++ L F Sbjct: 61 LGFN-----LTELSESDVHRGFQHLLHTLNLPGHGLETRVGSALFLSHNLKFLAKFLNDT 115 Query: 241 REYYFAEAQIADFSDPA-FISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSW 299 Y A+ +F D I N+H+ K T+G I D + + M+++N IYFK W Sbjct: 116 MAVYEAKLFHTNFYDTVGTIQLINDHVKKETRGKIVDLVSELKKDVLMVLVNYIYFKALW 175 Query: 300 VNKFPVEMTHNHNFRLNEREVVKVSMMQT-KGNFLAANDQELDCDILQLEYVGGISMLIV 358 F T +F ++E V+V MM + + +D+ L C +L+++Y G ++ + Sbjct: 176 EKPFISSRTTPKDFYVDENTTVRVPMMLQDQEHHWYLHDRYLPCSVLRMDYKGDATVFFI 235 Query: 359 VPHKMSGMKTLEAQLTPRVVERWQKSMTNR----TREVLLPKFKLEKNYNLVESLKLMGI 414 +P++ M+ +E LTP ++ RW + R E+ LPKF + +Y L + L +G Sbjct: 236 LPNQ-GKMREIEEVLTPEMLMRWNNLLRKRNFYKKLELHLPKFSISGSYVLDQILPRLGF 294 Query: 415 RMLFDKNGNMAGIS-DQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVR---FT 470 LF K +++GI+ Q++ H+ T+ V+E GT+A T+ S Q Sbjct: 295 TDLFSKWADLSGITKQQKLEASKSFHKATLDVDEAGTEAAAATSFAIKFFSAQTNRHILR 354 Query: 471 VDRPFLFLIYEHRTSCLLFMGRVANPSR 498 +RPFL +I+ T +LF+G+V +P++ Sbjct: 355 FNRPFLVVIFSTSTQSVLFLGKVVDPTK 382 >3DY0-A nrPDB Length = 336 Score = 392 bits (1007), Expect = e-109, Method: Composition-based stats. Identities = 95/332 (28%), Positives = 160/332 (48%), Gaps = 9/332 (2%) Query: 132 KFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASS 191 F F+LYR L NIF +PV IS ++ M+SLG T Q+ L Sbjct: 11 DFTFDLYRALASAA-PSQNIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLN-----LQ 64 Query: 192 KYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIA 251 K +H F++L L + G+ L N L+ + F + ++ Y A+ Sbjct: 65 KSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPT 124 Query: 252 DFSDPAFI-SKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHN 310 +F D A + N+++ K TKG I D L+N+D ++++N I+FK W F + T Sbjct: 125 NFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQE 184 Query: 311 HNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLE 370 +F + VV+V MM + + D+ L C ++ + Y G + L ++P + M+ +E Sbjct: 185 QDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSE-GKMQQVE 243 Query: 371 AQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQ 430 L+ + + +W K R E+ LPKF +E +Y L + L +GI +F + +++GIS+ Sbjct: 244 NGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNH 303 Query: 431 -RIAIDLFKHQGTITVNEEGTQATTVTTVGFM 461 I + H+ + V+E GT+A T F Sbjct: 304 SNIQVSEMVHKAVVEVDESGTRAAAATGTIFT 335 >5NCS-A nrPDB Length = 375 Score = 390 bits (1003), Expect = e-109, Method: Composition-based stats. Identities = 105/381 (27%), Positives = 180/381 (47%), Gaps = 17/381 (4%) Query: 119 GKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVH 178 G +++ NA FAF+L + + V T N+FI+P+ +S A+ M G G T +++ Sbjct: 1 GPLGSEKIEKDNA-FAFDLLQTTRKHV-TEANVFISPLSVSMALNMTLNGAAGVTADEMK 58 Query: 179 SILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKT 238 + L + Y + I+ L L + + T+ N ++ ++ + F Sbjct: 59 TALR-------ETGYTMEDINEYSHSLREALLKVDPSTTIGMANSIWYKQGELVKEPFIL 111 Query: 239 KVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGS 298 R +Y AE + DFS PA + N + T I L+ I M ++N +YFKG Sbjct: 112 ANRTHYDAEVKAVDFSSPATLPAINGWCAQKTNDKITKILDYIPGNAFMYLINAVYFKGI 171 Query: 299 WVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGI-SMLI 357 WV +F T FR + +V+MM K F D+ C L+++Y SM++ Sbjct: 172 WVTQFKKSDTKRAPFRKADGTTQEVNMMAQKSTFGYTTDE--CCQYLEMDYGNKAFSMIV 229 Query: 358 VVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNL-VESLKLMGIRM 416 ++P++ + + QL + K + + +P+FK E Y L + L MG+ + Sbjct: 230 MLPNEGQTTRDVIEQLDNKHWSMIIKGIRPTQVSLRMPRFKTECKYGLEKKILPEMGMNV 289 Query: 417 LFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFM----PLSTQVRFTVD 472 F + + GI+D I I H+ + V+EEGT+A VT V + P +T + F ++ Sbjct: 290 PFTETADFPGITDAAIFISRVIHKTFVQVDEEGTEAAAVTAVEMVKTSSPSTTPINFHIN 349 Query: 473 RPFLFLIYEHRTSCLLFMGRV 493 +PF+F I E T +LF+G + Sbjct: 350 KPFVFAIREKSTGVILFIGEI 370 >3NDA-A nrPDB Length = 377 Score = 390 bits (1001), Expect = e-109, Method: Composition-based stats. Identities = 115/377 (30%), Positives = 181/377 (48%), Gaps = 14/377 (3%) Query: 125 RLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFK 184 +L N +F L R L N+F +P +STAMGM G +G+T +++ L F Sbjct: 6 KLTKANNRFGLRLLRALPSG--PEKNVFFSPYSVSTAMGMAFAGARGQTQQELSQGLGFS 63 Query: 185 DFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYY 244 D + H+ T RL TL N IQ+ +L +++ ++ + Sbjct: 64 DVDLTDAGVLDAYTHH-----TERLKSTPSNSTLDVANAAAIQRTLALLNSYESALQSSF 118 Query: 245 FAEAQIADF--SDPAFISKTNNHIMKLTKGLIKDAL-ENIDPATQMMILNCIYFKGSWVN 301 AE DF A + NN + + T I+ E +DP T +++LN IYFKG W Sbjct: 119 GAELHKVDFAGEPQAAVDFVNNWVKRKTHDKIEKLFNEPLDPDTLLVLLNAIYFKGEWNT 178 Query: 302 KFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-GISMLIVVP 360 F E T F V+V M+ + +L ++++L Y G +M I++P Sbjct: 179 AFVKEHTEKRQFFNGGVTPVEVDTMRLEARIKYRFFDDLQVEVVELPYRGLDYTMAILLP 238 Query: 361 HKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDK 420 + +G++ L+ LT + + + R VLLPKFKLE Y+L L+ +GI+ +F+ Sbjct: 239 KENTGVEGLKQNLTIDRFQNYLSDLRERKITVLLPKFKLETKYSLKAPLQSLGIKQIFES 298 Query: 421 NGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLS---TQVRFTVDRPFLF 477 +++GI+D + + +H+ + VNEEGT A T V +P S V F VD PFLF Sbjct: 299 GADLSGINDGSLRVSAVEHKAVVEVNEEGTVAAATTGVVIVPYSLGPEPVVFRVDHPFLF 358 Query: 478 LIYEHRTSCLLFMGRVA 494 I RT + F+G+V Sbjct: 359 FIRNTRTDDIFFVGQVN 375 >1UHG-A nrPDB Length = 385 Score = 388 bits (998), Expect = e-108, Method: Composition-based stats. Identities = 112/384 (29%), Positives = 190/384 (49%), Gaps = 14/384 (3%) Query: 126 LNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKD 185 + + +F F++++ LK + +NIF P+ I +A+ M+ LG K T Q++ ++ F Sbjct: 3 IGAASMEFCFDVFKELKVH-HANENIFYCPIAIMSALAMVYLGAKDSTRTQINKVVRFDK 61 Query: 186 FVNASSKYEITT-----IHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKV 240 E +H+ R + +++ + N Y+ + LY ++++PIL ++ V Sbjct: 62 LPGFGDSIEAQCGTSVNVHSSLRDILNQITKPNDVYSFSLASRLYAEERYPILPEYLQCV 121 Query: 241 REYYFAEAQIADFSDPAFISK--TNNHIMKLTKGLIKDAL--ENIDPATQMMILNCIYFK 296 +E Y + +F A ++ N+ + T G+I++ L ++D T M+++N I FK Sbjct: 122 KELYRGGLEPINFQTAADQARELINSWVESQTNGIIRNVLQPSSVDSQTAMVLVNAIVFK 181 Query: 297 GSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYV-GGISM 355 G W F E T FR+ E+E V MM G F A+ IL+L + G +SM Sbjct: 182 GLWEKAFKDEDTQAMPFRVTEQESKPVQMMYQIGLFRVASMASEKMKILELPFASGTMSM 241 Query: 356 LIVVPHKMSGMKTLEAQLTPRVVERWQKS--MTNRTREVLLPKFKLEKNYNLVESLKLMG 413 L+++P ++SG++ LE+ + + W S M R +V LP+ K+E+ YNL L MG Sbjct: 242 LVLLPDEVSGLEQLESIINFEKLTEWTSSNVMEERKIKVYLPRMKMEEKYNLTSVLMAMG 301 Query: 414 IRMLFDKNGNMAGISD-QRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVD 472 I +F + N++GIS + + I H +NE G + G S F D Sbjct: 302 ITDVFSSSANLSGISSAESLKISQAVHAAHAEINEAGREVVGSAEAGVDAASVSEEFRAD 361 Query: 473 RPFLFLIYEHRTSCLLFMGRVANP 496 PFLF I T+ +LF GR +P Sbjct: 362 HPFLFCIKHIATNAVLFFGRCVSP 385 >2XN5-A nrPDB Length = 350 Score = 384 bits (986), Expect = e-107, Method: Composition-based stats. Identities = 96/355 (27%), Positives = 174/355 (49%), Gaps = 10/355 (2%) Query: 118 HGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQV 177 + + +++ +NA FAFNLYR + NIF +PV IS A+ M+S G T ++ Sbjct: 3 QPNATLYKMSSINADFAFNLYRRFTVET-PDKNIFFSPVSISAALVMLSFGACCSTQTEI 61 Query: 178 HSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFK 237 L F + + I + F+ L L L+ N L+I K L F Sbjct: 62 VETLGFN-----LTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFL 116 Query: 238 TKVREYYFAEAQIADFSD-PAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFK 296 V+ Y E DFS+ A + N+H+ TKG + ++++ P T M+++N I+FK Sbjct: 117 NDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFK 176 Query: 297 GSWVNKFPVEMTHN-HNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISM 355 W N F T + +F +++ V+V MM + D EL+C +LQ++Y Sbjct: 177 AQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALA 236 Query: 356 LIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIR 415 L V+P K M+++EA ++ + +++W + + ++ +PKF + Y+L +L MGI+ Sbjct: 237 LFVLP-KEGQMESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQ 295 Query: 416 MLFDKNGNMAGISDQR-IAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRF 469 + +N + +G+++ + + H+ + + E+GT+A + +P S F Sbjct: 296 HAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEKGTEAAGAMFLEAIPRSIPNTF 350 >1QMB-A nrPDB Length = 326 Score = 377 bits (969), Expect = e-105, Method: Composition-based stats. Identities = 94/335 (28%), Positives = 180/335 (53%), Gaps = 11/335 (3%) Query: 125 RLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFK 184 ++ A+FAF+LYR L Q +T NIF +PV I+TA M+SLG K +TH+++ L+F Sbjct: 1 KITPNLAEFAFSLYRQLAHQSST--NIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFN 58 Query: 185 DFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYY 244 ++ IH F++L L + + L + N L++ + ++ F V++ Y Sbjct: 59 -----LTEIPEAAIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLY 113 Query: 245 FAEAQIADFSDPAFISK-TNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKF 303 +EA +F D K N+++ K T+G I D ++ +D T ++N I+FKG W F Sbjct: 114 HSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPF 173 Query: 304 PVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKM 363 V+ T +F +++ VKV MM+ G F + ++L +L ++Y+G + + +P + Sbjct: 174 EVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDE- 232 Query: 364 SGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGN 423 ++ LE +LT ++ ++ ++ R+ + LPK + Y+L L +GI +F + Sbjct: 233 GKLQHLENELTHDIITKFLEN-DRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGAD 291 Query: 424 MAGISDQ-RIAIDLFKHQGTITVNEEGTQATTVTT 457 ++G++++ + + H+ +T++E+GT+A Sbjct: 292 LSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMF 326 >1C5G-A nrPDB Length = 402 Score = 377 bits (968), Expect = e-105, Method: Composition-based stats. Identities = 100/389 (25%), Positives = 181/389 (46%), Gaps = 22/389 (5%) Query: 118 HGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQV 177 H S + L + F +++ + Q + N+ +P G+++ + M+ L GET +Q+ Sbjct: 26 HPPSYVAHLA---SDFGVRVFQQVA-QASKDRNVVFSPYGVASVLAMLQLTTGGETQQQI 81 Query: 178 HSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFK 237 + + FK K + +L+++L + + + + +++Q+ ++ F Sbjct: 82 QAAMGFKI----DDKGMAPALRHLYKELMGPWNKD----EISTTDAIFVQRDLKLVQGFM 133 Query: 238 TKVREYYFAEAQIADFSDPAFISKT-NNHIMKLTKGLIKDALEN--IDPATQMMILNCIY 294 + + + DFS+ N+ + TKG+I + L +D T+++++N +Y Sbjct: 134 PHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALY 193 Query: 295 FKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELD---CDILQLEYVG 351 F G W FP TH F ++ V V MM F D DIL+L Y G Sbjct: 194 FNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHG 253 Query: 352 G-ISMLIVVP-HKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESL 409 +SM I P K + L L+ +++ W+ +MT R ++LPKF LE +L + L Sbjct: 254 DTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPL 313 Query: 410 KLMGIRMLFDK-NGNMAGISDQ-RIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQV 467 + +G+ +F + + +SDQ + + + I VNE GT A++ T V Sbjct: 314 ENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPE 373 Query: 468 RFTVDRPFLFLIYEHRTSCLLFMGRVANP 496 +DRPFLF++ + T +LFMG+V P Sbjct: 374 EIIMDRPFLFVVRHNPTGTVLFMGQVMEP 402 >2V95-A nrPDB Length = 371 Score = 376 bits (966), Expect = e-104, Method: Composition-based stats. Identities = 103/381 (27%), Positives = 175/381 (45%), Gaps = 12/381 (3%) Query: 119 GKSRIQR-LNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQV 177 G S R L N FAFNLY+ L +N N I+PV IS A+ M+SLG Q Sbjct: 1 GSSNSHRGLAPTNVDFAFNLYQRLV-ALNPDKNTLISPVSISMALAMVSLGSA---QTQS 56 Query: 178 HSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFK 237 L F ++ IH F+ L + L + + G + N +++ ++ + F Sbjct: 57 LQSLGFN-----LTETSEAEIHQSFQYLNYLLKQSDTGLEMNMGNAMFLLQKLKLKDSFL 111 Query: 238 TKVREYYFAEAQIADFSDPAFI-SKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFK 296 V++YY +EA DF D + N H+ T+G I+ ++D +++N I+ + Sbjct: 112 ADVKQYYESEALAIDFEDWTKASQQINQHVKDKTQGKIEHVFSDLDSPASFILVNYIFLR 171 Query: 297 GSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISML 356 G W F E T +F +NE VKV MM G+ D C ++Q++YVG + Sbjct: 172 GIWELPFSPENTREEDFYVNETSTVKVPMMVQSGSIGYFRDSVFPCQLIQMDYVGNGTAF 231 Query: 357 IVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRM 416 ++P + M T+ A L+ ++RW K MT R + +PKF + Y+L + L+ + I+ Sbjct: 232 FILPDQ-GQMDTVIAALSRDTIDRWGKLMTPRQVNLYIPKFSMSDTYDLKDVLEDLNIKD 290 Query: 417 LFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFL 476 L + +G + H+ + ++E + S + ++PF+ Sbjct: 291 LLTNQSDFSGNTKDVPLTLTMVHKAMLQLDEGNVLPNSTNGAPLHLRSEPLDIKFNKPFI 350 Query: 477 FLIYEHRTSCLLFMGRVANPS 497 L+++ T L M +V NP+ Sbjct: 351 LLLFDKFTWSSLMMSQVVNPA 371 >2H4P-A nrPDB Length = 394 Score = 369 bits (948), Expect = e-102, Method: Composition-based stats. Identities = 104/371 (28%), Positives = 185/371 (49%), Gaps = 32/371 (8%) Query: 122 RIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSIL 181 +++++ F +L+ L ++ N NIF +P IS+A+ + L KG T ++ +L Sbjct: 25 SMEQVSASIGNFTVDLFNKL-NETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVL 83 Query: 182 HFKDFVNASSKY-------------------EITTIHNLFRKLTHRLFRRNFGYTLRSVN 222 HF + V A S + IH+ F++L + Y+LRS N Sbjct: 84 HFTEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSAN 143 Query: 223 DLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISK--TNNHIMKLTKGLIKDAL-- 278 +Y++K + +L + ++YY AE Q +F S+ N + K T+ IK+ L Sbjct: 144 RIYVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSS 203 Query: 279 ENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQ 338 +++ T+++++N IYFK W KF E T FRL++ + V MM + F + Sbjct: 204 DDVKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIME 263 Query: 339 ELDCDILQLEY-VGGISMLIVVPHKM----SGMKTLEAQLTPRVVERW--QKSMTNRTRE 391 +++ +++L Y +SM I++P + +G++ LE +LT + W K MT + Sbjct: 264 KMNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVD 323 Query: 392 VLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQR-IAIDLFKHQGTITVNEEGT 450 + LPKF LE +L ++L+ MG+ F N + G++D++ +AI HQ + V+E+GT Sbjct: 324 LHLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGT 383 Query: 451 QATTVTTVGFM 461 +A T V Sbjct: 384 EAAAATAVIIS 394 >4P0F-A nrPDB Length = 393 Score = 368 bits (945), Expect = e-102, Method: Composition-based stats. Identities = 100/384 (26%), Positives = 170/384 (44%), Gaps = 24/384 (6%) Query: 124 QRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHF 183 Q A F+ N+Y L Q +NI +P I T M LG + ET Q+ L Sbjct: 8 QEFARRLALFSINVYGKLSGQK-PGENIVFSPFSIQTCAAMARLGAENETATQLDQGLGL 66 Query: 184 KDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREY 243 + + I + F ++ L LR N +++ + + +F + + Sbjct: 67 -------ASSDPEQIAHSFHQV---LAAYQDSQILRIANKIFVMDGYQLRQEFDQLLSKQ 116 Query: 244 YFAEAQIADFSDPAFISK-TNNHIMKLTKGLIKDALEN--IDPATQMMILNCIYFKGSWV 300 + + AQ DFS + NN + + T LIKD + ++ ++++++N I+FKG+W Sbjct: 117 FLSAAQSVDFSKNVQAAATINNWVEQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGTWQ 176 Query: 301 NKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYV-GGISMLIVV 359 ++F +T F L+ V+V MM K F A+ LD L+L Y +SMLIV+ Sbjct: 177 HQFAKHLTRPDTFHLDGERTVQVPMMSLKERFRYADLPALDAMALELPYKDSDLSMLIVL 236 Query: 360 PHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFD 419 P+ +G+ LE +L + + +S+ + LP+FK E L E + +G+ +F Sbjct: 237 PNTKTGLPALEEKLRLTTLSQITQSLYETKVALKLPRFKAEFQVELSEVFQKLGMSRMFS 296 Query: 420 KNGNMAGI--SDQRIAIDLFKHQGTITVNEEGTQATTVTTV------GFMPLSTQVRFTV 471 + S + + + H+ I VNEEGT+A T + M + F Sbjct: 297 DQAEFGKMLQSPEPLKVSAIIHKAFIEVNEEGTEAAAATGMAVRRKRAIMSPEEPIEFFA 356 Query: 472 DRPFLFLIYEHRTSCLLFMGRVAN 495 D PF +++ + LF G V Sbjct: 357 DHPFTYVLVHQK-DLPLFWGSVVR 379 >2H4Q-A nrPDB Length = 382 Score = 368 bits (944), Expect = e-102, Method: Composition-based stats. Identities = 102/352 (28%), Positives = 182/352 (51%), Gaps = 22/352 (6%) Query: 122 RIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSIL 181 +++++ F +L+ L ++ N NIF +P IS+A+ + L KG T ++ +L Sbjct: 41 SMEQVSASIGNFTVDLFNKL-NETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVL 99 Query: 182 HFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVR 241 HF+ N IH+ F++L + Y+LRS N +Y++K + +L + + Sbjct: 100 HFEQAEN---------IHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTYLQLSK 150 Query: 242 EYYFAEAQIADFSDPAFISK--TNNHIMKLTKGLIKDAL--ENIDPATQMMILNCIYFKG 297 +YY AE Q +F S+ N + K T+ IK+ L +++ T+++++N IYFK Sbjct: 151 KYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILVNAIYFKA 210 Query: 298 SWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEY-VGGISML 356 W KF E T FRL++ + V MM + F ++++ +++L Y +SM Sbjct: 211 EWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPYVKRELSMF 270 Query: 357 IVVPHKM----SGMKTLEAQLTPRVVERW--QKSMTNRTREVLLPKFKLEKNYNLVESLK 410 I++P + +G++ LE +LT + W K MT ++ LPKF LE +L ++L+ Sbjct: 271 ILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDRIDLRDTLR 330 Query: 411 LMGIRMLFDKNGNMAGISDQR-IAIDLFKHQGTITVNEEGTQATTVTTVGFM 461 MG+ F N + G++D++ +AI HQ + V+E+GT+A T V Sbjct: 331 NMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAVAATAVIIS 382 >4KDS-A nrPDB Length = 386 Score = 366 bits (941), Expect = e-102, Method: Composition-based stats. Identities = 96/389 (24%), Positives = 177/389 (45%), Gaps = 22/389 (5%) Query: 120 KSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHS 179 + I L F ++ + Q + N+ +P G++T + M LG G T + +++ Sbjct: 9 SAAISNLQEKQTDFGMRVFSQVA-QNSKGSNLAFSPYGVATILAMAQLGAGGNTLKTLNA 67 Query: 180 ILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTK 239 L F ++ ++L R G L + + ++++ + F+ Sbjct: 68 KLGFSLQERGMARQ---------QRLLQRDISSEEGVEL--ASGVMVERKMALEKGFRRG 116 Query: 240 VREYYFAEAQIADFSDPAFI-SKTNNHIMKLTKGLIKDALEN--IDPATQMMILNCIYFK 296 + + + A DFS P N + T G I L + + T+M++LN ++F+ Sbjct: 117 LGKAFQASPHQLDFSRPDQALDIINAWVSDHTAGTIPSFLSSGALTDETRMVLLNALHFQ 176 Query: 297 GSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAAND---QELDCDILQLEYVG-G 352 G W F +MT F V V MM+ F +D D++++ Y G Sbjct: 177 GLWKVPFDPKMTEERLFHCANGSSVPVPMMRLTHRFKYGEFVTPDGVDYDVIEVPYEGES 236 Query: 353 ISMLIVVP-HKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKL 411 +SML+V P + + +L ++LT + +++W++ M + R+++LP+F L+ L L Sbjct: 237 LSMLLVSPFEPETPVSSLSSELTTQRLQQWRQEMRSVKRQLVLPRFTLDSEVELKSILIQ 296 Query: 412 MGIRMLFD-KNGNMAGIS-DQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRF 469 MG+ +F+ + I+ +Q + + + I VNEEGT+A+ T Sbjct: 297 MGLGDMFNLAKADFTRITTEQPLCVSKVLQKVKIEVNEEGTKASAATAAILFSRMAVEEI 356 Query: 470 TVDRPFLFLIYEHRTSCLLFMGRVANPSR 498 T++RPFLFLI+ T +LFMG+V P + Sbjct: 357 TMNRPFLFLIHHKSTGAVLFMGQVNQPQQ 385 >5INW-A nrPDB Length = 421 Score = 365 bits (938), Expect = e-101, Method: Composition-based stats. Identities = 101/343 (29%), Positives = 177/343 (51%), Gaps = 7/343 (2%) Query: 124 QRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHF 183 QR+ F LY+ + DNIF +P+ I++A+G+++ G G T ++ + L F Sbjct: 79 QRIASAVNGLGFRLYKQVLGGAGPADNIFFSPLSIASALGVVTAGANGSTRAELDTALGF 138 Query: 184 KDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREY 243 K+F++ K + F +L L++R+ G+ L N ++ +K + F V Sbjct: 139 KEFLHGKKKAKSM---KYFARLNGALYKRSAGFELMGKNVVFSKKGLWLYRQFTRTVAHL 195 Query: 244 YFAEAQIADFSDP-AFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNK 302 + + + DF D + N +I K+T D + ++D T ++I+N IYFKGSW NK Sbjct: 196 FKSNVRSVDFGDSKNAVELMNAYIEKVTSKKFPDVISDVDTDTSLVIVNVIYFKGSWGNK 255 Query: 303 FPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHK 362 F ++T N F +N + V M + D++L +++L Y GG SML++VPH+ Sbjct: 256 FEPDLTKNVRFWVNSSYSMMVPTMHQRAKLSYTQDRKLRSTVVKLPYEGGASMLVIVPHR 315 Query: 363 MSGMKTLEAQLTPRVVERWQKSM--TNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDK 420 + +E ++ +E W + +N ++ LPKFK+ +Y+L L MG+ +F Sbjct: 316 TEDLPKVEESVSQEQLEEWLSLLGPSNHYVQLSLPKFKISVSYDLKAYLSAMGMSSMFSY 375 Query: 421 NGNMAGISD-QRIAIDLFKHQGTITVNEEGTQATTVTTVGFMP 462 +++ I+ Q++ +D H+ + VNEEGT+A T VG M Sbjct: 376 GADLSRITGMQKLHVDKITHKSVLHVNEEGTEAKAETVVGIMA 418 >3LW2-A nrPDB Length = 379 Score = 365 bits (937), Expect = e-101, Method: Composition-based stats. Identities = 92/376 (24%), Positives = 171/376 (45%), Gaps = 19/376 (5%) Query: 131 AKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNAS 190 F +++ + Q + N+ +P G+S+ + M+ + G+T Q+ + FK + Sbjct: 13 TDFGVKVFQQVV-QASKDRNVVFSPYGVSSVLAMLQMTTAGKTRRQIQDAMGFKVNEKGT 71 Query: 191 SKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQI 250 + + R+L+ L + + + +++Q+ ++ F + + + Sbjct: 72 A--------HALRQLSKELMGPWNKNEISTADAIFVQRDLELVQGFMPHFFKLFQTMVKQ 123 Query: 251 ADFSDPAFISKT-NNHIMKLTKGLIKDALEN--IDPATQMMILNCIYFKGSWVNKFPVEM 307 DFS+ N+ + + TKG+I D L +D T+++++N +YF G W F Sbjct: 124 VDFSEVERARFIINDWVERHTKGMINDLLAKGAVDELTRLVLVNALYFSGQWKTPFLEAS 183 Query: 308 THNHNFRLNEREVVKVSMMQTKGNFLAAND---QELDCDILQLEYVGG-ISMLIVVP-HK 362 TH F ++ V V MM F L+ D+++L Y G +SM I P K Sbjct: 184 THQRLFHKSDGSTVSVPMMAQSNKFNYTEFTTPDGLEYDVVELPYQGDTLSMFIAAPFEK 243 Query: 363 MSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKN- 421 + L L ++ +W+ +MT R ++LPKF LE +L L+ +G+ +F Sbjct: 244 DVHLSALTNILDAELIRQWKGNMTRLPRLLILPKFSLETEVDLRGPLEKLGMPDMFSATL 303 Query: 422 GNMAGISDQ-RIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIY 480 + +SDQ ++++ + I VNE GT A++ T +DR FLF++ Sbjct: 304 ADFTSLSDQEQLSVAQALQKVRIEVNESGTVASSSTAFVISARMAPTEMVIDRSFLFVVR 363 Query: 481 EHRTSCLLFMGRVANP 496 + T +LFMG+V P Sbjct: 364 HNPTETILFMGQVMEP 379 >4DY0-A nrPDB Length = 379 Score = 365 bits (937), Expect = e-101, Method: Composition-based stats. Identities = 98/383 (25%), Positives = 185/383 (48%), Gaps = 23/383 (6%) Query: 126 LNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKD 185 L L + ++ + DNI I+P GI++ +GM+ LG G T +Q+ ++ + Sbjct: 8 LEELGSNTGIQVFNQIVKSRPH-DNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYG- 65 Query: 186 FVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYF 245 + + + +K+ + + + N ++++ I + F T+ ++ + Sbjct: 66 ---------VNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQ 116 Query: 246 AEAQIADFSDPAFI-SKTNNHIMKLTKGLIKDALEN--IDPA-TQMMILNCIYFKGSWVN 301 E + +F DPA N + T+ +I + L ID T+++++N +YFKG W + Sbjct: 117 CEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKS 176 Query: 302 KFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQ---ELDCDILQLEYVG-GISMLI 357 +F E T F + + +V M+ F + +L + ++L Y G ISMLI Sbjct: 177 RFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLI 236 Query: 358 VVPHKM-SGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRM 416 +P + + + + ++ + ++ W M + +V+LPKF +L E LK++GI Sbjct: 237 ALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITD 296 Query: 417 LFDKN-GNMAGIS--DQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDR 473 +FD + N A I+ + + + + I V+E+GT+A+ TT + S+ F VDR Sbjct: 297 MFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDR 356 Query: 474 PFLFLIYEHRTSCLLFMGRVANP 496 PFLF I + T +LFMG++ P Sbjct: 357 PFLFFIRHNPTGAVLFMGQINKP 379 >1HLE-A nrPDB Length = 345 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 105/337 (31%), Positives = 180/337 (53%), Gaps = 23/337 (6%) Query: 123 IQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILH 182 +++L+ N FA +L+R L ++ + NIFI+P+ IS+A+ MI LG +G T QV L+ Sbjct: 2 MEQLSTANTHFAVDLFRAL-NESDPTGNIFISPLSISSALAMIFLGTRGNTAAQVSKALY 60 Query: 183 FKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVRE 242 F + IH+ F+ L + + Y L+ N LY +K + L DF ++ Sbjct: 61 FDT---------VEDIHSRFQSLNADINKPGAPYILKLANRLYGEKTYNFLADFLASTQK 111 Query: 243 YYFAEAQIADFSDPAFISK--TNNHIMKLTKGLIKDALEN--IDPATQMMILNCIYFKGS 298 Y AE DF ++ N + T+G I + L +D T+++++N IYFKG+ Sbjct: 112 MYGAELASVDFQQAPEDARKEINEWVKGQTEGKIPELLVKGMVDNMTKLVLVNAIYFKGN 171 Query: 299 WVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-GISMLI 357 W KF E T + FRLN+++ V MM K F ++L C +L+L Y G +SM+I Sbjct: 172 WQQKFMKEATRDAPFRLNKKDTKTVKMMYQKKKFPYNYIEDLKCRVLELPYQGKELSMII 231 Query: 358 VVPHKM----SGMKTLEAQLTPRVVERWQK--SMTNRTREVLLPKFKLEKNYNLVESLKL 411 ++P + +G++ +E QLT + W K ++ V LP+FKLE++Y+L L Sbjct: 232 LLPDDIEDESTGLEKIEKQLTLDKLREWTKPENLYLAEVNVHLPRFKLEESYDLTSHLAR 291 Query: 412 MGIRMLFDKN-GNMAGISDQR-IAIDLFKHQGTITVN 446 +G++ LF++ +++G+S R + + H+ + +N Sbjct: 292 LGVQDLFNRGKADLSGMSGARDLFVSKIIHKSFVDLN 328 >4AJU-A nrPDB Length = 387 Score = 359 bits (922), Expect = 1e-99, Method: Composition-based stats. Identities = 100/343 (29%), Positives = 164/343 (47%), Gaps = 10/343 (2%) Query: 124 QRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHF 183 Q+L + F F+L R K + N+ +P G+S AM + LG G T Q+ LH Sbjct: 52 QQLAKETSNFGFSLLR--KISMRHDGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHL 109 Query: 184 KDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREY 243 A + + +LF+ L L RN L + +I K F + F + Y Sbjct: 110 ----QALKPTKPGLLPSLFKGLRETL-SRNLELGLTQGSFAFIHKDFDVKETFFNLSKRY 164 Query: 244 YFAEAQIADFSDPAFISK-TNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNK 302 + E +F + + + N++I K T+G I + I+P T++++++ I FKG W+ Sbjct: 165 FDTECVPMNFRNASQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKGKWLTP 224 Query: 303 FPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHK 362 F T F L++ + +KV MM G F + D+ C +L+L Y G +ML+V+ K Sbjct: 225 FDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLVVLMEK 284 Query: 363 MSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNG 422 M LE LT +VE W ++M R EV PKFKL++ Y + E L+ MGIR +F Sbjct: 285 MGDHLALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFSPFA 344 Query: 423 NMAGI--SDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPL 463 +++ + + + + + + I V+E GT+A Sbjct: 345 DLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAR 387 >6F4U-A nrPDB Length = 341 Score = 358 bits (920), Expect = 3e-99, Method: Composition-based stats. Identities = 90/329 (27%), Positives = 155/329 (47%), Gaps = 14/329 (4%) Query: 125 RLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFK 184 ++ NA FAF Y ++ + NIF +P+ IS A M+SLG + Q+ L F Sbjct: 4 KIAPANADFAFRFYYLIASET-PGKNIFFSPLSISAAYAMLSLGACSHSRSQILEGLGFN 62 Query: 185 DFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYY 244 ++ + +H F+ L H L G R + L++ L F Y Sbjct: 63 -----LTELSESDVHRGFQHLLHTLNLPGHGLETRVGSALFLSHNLKFLAKFLNDTMAVY 117 Query: 245 FAEAQIADFSDPA-FISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKF 303 A+ +F D I N+H+ K T+G I D + + M+++N IYFK W F Sbjct: 118 EAKLFHTNFYDTVGTIQLINDHVKKETRGKIVDLVSELKKDVLMVLVNYIYFKALWEKPF 177 Query: 304 PVEMTHNHNFRLNEREVVKVSMMQT-KGNFLAANDQELDCDILQLEYVGGISMLIVVPHK 362 T +F ++E V+V MM + + +D+ L C +L+++Y G ++ ++P++ Sbjct: 178 ISSRTTPKDFYVDENTTVRVPMMLQDQEHHWYLHDRYLPCSVLRMDYKGDATVFFILPNQ 237 Query: 363 MSGMKTLEAQLTPRVVERWQKSMTNR----TREVLLPKFKLEKNYNLVESLKLMGIRMLF 418 M+ +E LTP ++ RW + R E+ LPKF + +Y L + L +G LF Sbjct: 238 -GKMREIEEVLTPEMLMRWNNLLRKRNFYKKLELHLPKFSISGSYVLDQILPRLGFTDLF 296 Query: 419 DKNGNMAGIS-DQRIAIDLFKHQGTITVN 446 K +++GI+ Q++ H+ T+ V+ Sbjct: 297 SKWADLSGITKQQKLEASKSFHKATLDVD 325 >4DTE-A nrPDB Length = 374 Score = 349 bits (896), Expect = 2e-96, Method: Composition-based stats. Identities = 85/379 (22%), Positives = 164/379 (43%), Gaps = 22/379 (5%) Query: 130 NAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNA 189 F ++ Q N+ ++P GI++ +GM +G G T + + S + + Sbjct: 7 QTDFGLQVFAE-AVQSAPDRNLALSPYGIASVLGMAQMGAYGATLKLLASKMGYSLQERG 65 Query: 190 SSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQ 249 K ++L R G + + + ++ + F+ + + + + Sbjct: 66 MPK---------LQRLLQRDLASEDGVE--VASGVMVDRKIILEKVFRRSLSKAFQSVPH 114 Query: 250 IADFSDPAFISK-TNNHIMKLTKGLIKDALEN--IDPATQMMILNCIYFKGSWVNKFPVE 306 DFS P + N+ T G+I + L + + T+++ LN ++F G W F Sbjct: 115 QIDFSQPEMARQVINSWTSDHTDGMISEFLPSGVLSELTRLVFLNALHFHGVWKTPFDPR 174 Query: 307 MTHNHNFRLNEREVVKVSMMQTKGNFLAAND---QELDCDILQLEYVG-GISMLIVVP-H 361 T F V V MM T F +D D++++ Y G ISML+V P Sbjct: 175 NTREQLFHTVNGSAVSVPMMTTTQKFNYGEFVSKDGVDYDVIEMPYEGESISMLLVTPFE 234 Query: 362 KMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKN 421 K + L +L+ + +W++ M ++++ +P+F ++ +L +L MG+ +F ++ Sbjct: 235 KDVPLSALNKELSSSRIHQWRQEMRKISKQLSIPRFSMDTEIDLKSTLSRMGLGDIFSQS 294 Query: 422 -GNMAGIS-DQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLI 479 + + I+ ++ + + + + VNEEGT+ ++ T T+DRPF FLI Sbjct: 295 RADFSRITTEEPLCVSKVLQRVKLEVNEEGTKGSSATAAVIYSRMAVEEITLDRPFFFLI 354 Query: 480 YEHRTSCLLFMGRVANPSR 498 T LLF G++ P Sbjct: 355 QHKPTGALLFSGQLTQPQE 373 >5NCU-A nrPDB Length = 336 Score = 349 bits (895), Expect = 2e-96, Method: Composition-based stats. Identities = 93/345 (26%), Positives = 159/345 (46%), Gaps = 13/345 (3%) Query: 119 GKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVH 178 G +++ NA FAF+L + + V T N+FI+P+ +S A+ M G G T +++ Sbjct: 1 GPLGSEKIEKDNA-FAFDLLQTTRKHV-TEANVFISPLSVSMALNMTLNGAAGVTADEMK 58 Query: 179 SILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKT 238 + L + Y + I+ L L + + T+ N ++ ++ + F Sbjct: 59 TALR-------ETGYTMEDINEYSHSLREALLKVDPSTTIGMANSIWYKQGELVKEPFIL 111 Query: 239 KVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGS 298 R +Y AE + DFS PA + N + T I L+ I M ++N +YFKG Sbjct: 112 ANRTHYDAEVKAVDFSSPATLPAINGWCAQKTNDKITKILDYIPGNAFMYLINAVYFKGI 171 Query: 299 WVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGI-SMLI 357 WV +F T FR + +V+MM K F D+ C L+++Y SM++ Sbjct: 172 WVTQFKKSDTKRAPFRKADGTTQEVNMMAQKSTFGYTTDE--CCQYLEMDYGNKAFSMIV 229 Query: 358 VVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNL-VESLKLMGIRM 416 ++P++ + + QL + K + + +P+FK E Y L + L MG+ + Sbjct: 230 MLPNEGQTTRDVIEQLDNKHWSMIIKGIRPTQVSLRMPRFKTECKYGLEKKILPEMGMNV 289 Query: 417 LFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFM 461 F + + GI+D I I H+ + V+EEGT+A VT V + Sbjct: 290 PFTETADFPGITDAAIFISRVIHKTFVQVDEEGTEAAAVTAVEMV 334 >2R9Y-A nrPDB Length = 430 Score = 346 bits (887), Expect = 2e-95, Method: Composition-based stats. Identities = 101/382 (26%), Positives = 181/382 (47%), Gaps = 20/382 (5%) Query: 120 KSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHS 179 +RL F +L+ ++ Q +T N+ ++P+ ++ A+ ++LG + +T +H Sbjct: 15 AEETRRLAQAMMAFTTDLFSLVA-QTSTSSNLVLSPLSVALALSHLALGAQNQTLHSLHR 73 Query: 180 ILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTK 239 +LH + L ++ T+R +Y+QK FPI DF + Sbjct: 74 VLHMNT-------------GSCLPHLLSHFYQNLGPGTIRLAARIYLQKGFPIKDDFLEQ 120 Query: 240 VREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSW 299 + A+ ++ N + + T+G I+D L + +T +++LN I+F G W Sbjct: 121 SERLFGAKPVKLTGKQEEDLANINQWVKEATEGKIEDFLSELPDSTVLLLLNAIHFHGFW 180 Query: 300 VNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAAN-DQELDCDILQLEYVGGISMLIV 358 KF +T F L+ER V V MM L ++ + + + +S ++V Sbjct: 181 RTKFDPSLTQKDFFHLDERFTVSVDMMHAVSYPLRWFLLEQPEIQVAHFPFKNNMSFVVV 240 Query: 359 VPHKMS-GMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRML 417 +P + + A LT + + S+ R +V LPK L++ +LV +L +G++ L Sbjct: 241 MPTYFEWNVSEVLANLTWDTL--YHPSLQERPTKVWLPKLHLQQQLDLVATLSQLGLQEL 298 Query: 418 FDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLF 477 F + ++ GIS+Q + + +HQ T+ ++E G +A T+V +S FTV+RPFLF Sbjct: 299 F-QGPDLRGISEQNLVVSSVQHQSTMELSEAGVEAAAATSVAMNRMSLS-SFTVNRPFLF 356 Query: 478 LIYEHRTSCLLFMGRVANPSRS 499 I E LF+G V NP+ S Sbjct: 357 FIMEDTIGVPLFVGSVRNPNPS 378 >3F02-A nrPDB Length = 359 Score = 344 bits (882), Expect = 6e-95, Method: Composition-based stats. Identities = 91/347 (26%), Positives = 174/347 (50%), Gaps = 19/347 (5%) Query: 128 ILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFV 187 A + N+Y L+ +NI +P+ I+ AMGM+ LG +G T +++ + + Sbjct: 21 EAIADLSVNMYNRLR-ATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLK 79 Query: 188 NASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAE 247 N + ++ ++ + + Y ++ N L++Q F + +F +++Y+ A Sbjct: 80 NGEE-------FSFLKEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAA 132 Query: 248 AQIADFSDPAFISK-TNNHIMKLTKGLIKDALE--NIDPATQMMILNCIYFKGSWVNKFP 304 DFS ++ N + T L+KD + + D AT + ++N +YFKG+W ++F Sbjct: 133 VNHVDFSQNVAVANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFR 192 Query: 305 VEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELD------CDILQLEYVGG-ISMLI 357 E T +F ++ V++ MM +G F + +L++ Y G ISM++ Sbjct: 193 PENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMML 252 Query: 358 VVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRML 417 V+ + + TLE + ++VE W S+ + EV LP+F +E+ +L + LK +GI + Sbjct: 253 VLSRQEVPLATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEI 312 Query: 418 FDKNGNMAGISDQR-IAIDLFKHQGTITVNEEGTQATTVTTVGFMPL 463 F K+ N+ G+SD + I + H+ + VNEEG++A V+ + + Sbjct: 313 FIKDANLTGLSDNKEIFLSKAIHKSFLEVNEEGSEAAAVSGMIAISR 359 >1IMV-A nrPDB Length = 398 Score = 338 bits (867), Expect = 3e-93, Method: Composition-based stats. Identities = 90/381 (23%), Positives = 181/381 (47%), Gaps = 17/381 (4%) Query: 120 KSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHS 179 K + +L + F ++LYR ++ ++ N+ ++P+ ++TA+ +SLG T +H Sbjct: 28 KVPVNKLAAAVSNFGYDLYR-VRSSMSPTTNVLLSPLSVATALSALSLGADERTESIIHR 86 Query: 180 ILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTK 239 L++ + IH +++L + L+S + + +K+ I F Sbjct: 87 ALYYDLISS-------PDIHGTYKELLDTVTAPQKN--LKSASRIVFEKKLRIKSSFVAP 137 Query: 240 VREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSW 299 + + Y ++ + + + NN + KG + + + I +++L +FKG W Sbjct: 138 LEKSYGTRPRVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGVAHFKGQW 197 Query: 300 VNKFPVEMTHNHNFRLNEREVVKVSMMQT-KGNFLAANDQELDCDILQLEYVGGISMLIV 358 V KF T +F L+E V+V MM K D +L C I QL G +S++ Sbjct: 198 VTKFDSRKTSLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSIIFF 257 Query: 359 VPHKMSG-MKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRML 417 +P K++ + +E LT + + + + +PK KL + +SL+ M ++ L Sbjct: 258 LPLKVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSL 317 Query: 418 FDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMP--LSTQVRFTVDRPF 475 FD + + + I+ + I + +H+ NE+G A T + G P L+ + + +++PF Sbjct: 318 FD-SPDFSKITGKPIKLTQVEHRAGFEWNEDG--AGTTPSPGLQPAHLTFPLDYHLNQPF 374 Query: 476 LFLIYEHRTSCLLFMGRVANP 496 +F++ + T LLF+G++ +P Sbjct: 375 IFVLRDTDTGALLFIGKILDP 395 >3ZHA-A nrPDB Length = 392 Score = 331 bits (848), Expect = 5e-91, Method: Composition-based stats. Identities = 88/377 (23%), Positives = 171/377 (45%), Gaps = 14/377 (3%) Query: 126 LNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKD 185 L +A AF+LY+ + +NI ++PV +++++G++SLG K T Q ++L + Sbjct: 9 LAERSAGLAFSLYQAMAKDQ-AVENILLSPVVVASSLGLVSLGGKATTASQAKAVLSAEQ 67 Query: 186 FVNASSKYEITTIHNLFRKLTHRL-FRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYY 244 + +H +L L T + + LY DF +++Y Sbjct: 68 LRDEE-------VHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFAEDFVRSSKQHY 120 Query: 245 FAEAQIADFSDP-AFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKF 303 E +F D + + N + T G + + ++++ +++N ++FK W KF Sbjct: 121 NCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKF 180 Query: 304 PVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVV-PHK 362 +M N F + V V+MM G + +D++ I+++ +S LI++ PH Sbjct: 181 HHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHH 240 Query: 363 MSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKN- 421 + ++ LE LT ++ W M + + LPK +E ++L + L +G+ DKN Sbjct: 241 VEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNK 300 Query: 422 GNMAGISDQR-IAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIY 480 +++ +S ++ + + H + EG G L + F D PF+FL+ Sbjct: 301 ADLSRMSGKKDLYLASVFHATAFEWDTEGNPFDQ-DIYGREELRSPKLFYADHPFIFLVR 359 Query: 481 EHRTSCLLFMGRVANPS 497 + ++ LLF+GR+ P Sbjct: 360 DTQSGSLLFIGRLVRPK 376 >1XQJ-A nrPDB Length = 389 Score = 329 bits (844), Expect = 2e-90, Method: Composition-based stats. Identities = 96/393 (24%), Positives = 202/393 (51%), Gaps = 27/393 (6%) Query: 117 FHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQ 176 F G + L + N+ FA +L++ L ++ N+ +P+ +ST++ + +G KG+T + Sbjct: 11 FQGS--MDALQLANSAFAVDLFKQLSEK-EPLGNVLFSPIALSTSLSLAQVGAKGDTANE 67 Query: 177 VHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDF 236 + +LHF++ + + F+ +T + + + Y+L+ + LY+ K + +F Sbjct: 68 IGQVLHFEN---------VKDVPFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLSTEF 118 Query: 237 KTKVREYYFAEAQIADFSDPAFISK--TNNHIMKLTKGLIKDALEN--IDPATQMMILNC 292 + + Y E + DF D +K NN I LT G ++ L + ++ T+++++N Sbjct: 119 ISSTKRPYAKELETVDFKDKLEETKGQINNSIKDLTDGHFENILADNSVNDQTKILVVNA 178 Query: 293 IYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG- 351 YF G W+ KF T FR+N+ + V MM + F N ++ I++L + Sbjct: 179 AYFVGKWMKKFSESETKESPFRVNKTDTKPVQMMNMEATFSMGNIDSINSKIIELPFQNK 238 Query: 352 GISMLIVVP----HKMSGMKTLEAQLTPRVVERWQK--SMTNRTREVLLPKFKLEKNYNL 405 +SM I++P + +G++ +E QL + +W +M N ++ +PKFK+EK + Sbjct: 239 HLSMFILLPKDVEDESTGLEKIEKQLNSESLSQWTNPSTMANAKVKLSIPKFKVEKMIDP 298 Query: 406 VESLKLMGIRMLFDKN-GNMAGISDQR-IAIDLFKHQGTITVNEEGTQATTVTTVGFMPL 463 SL+ +G++ +F ++ + +G+S+ + +A+ H+ ++ + E+G + V L Sbjct: 299 KASLENLGLKHIFSEDTSDFSGMSETKGVALSNVIHKVSLEITEDGGDSIEVPGARI--L 356 Query: 464 STQVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496 + D PF+++I ++T ++F G+ ++P Sbjct: 357 QHKDELNADHPFIYIIRHNKTRNIIFFGKFSSP 389 >3LE2-A nrPDB Length = 393 Score = 326 bits (835), Expect = 2e-89, Method: Composition-based stats. Identities = 98/391 (25%), Positives = 167/391 (42%), Gaps = 31/391 (7%) Query: 128 ILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFV 187 L + + NL + + V+ N+ +P I+ + +I+ G G T +Q+ S L F Sbjct: 10 SLQNQVSMNLAKHVITTVSQNSNVIFSPASINVVLSIIAAGSAGATKDQILSFLKFS--- 66 Query: 188 NASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAE 247 S ++ + + N G L N +I K FK + + Y A Sbjct: 67 ---STDQLNSFSSEIVSAVLADGSANGGPKLSVANGAWIDKSLSFKPSFKQLLEDSYKAA 123 Query: 248 AQIADFSDPAF--ISKTNNHIMKLTKGLIKDALE--NIDPATQMMILNCIYFKGSWVNKF 303 + ADF A I++ N+ K T GLI + L + D T+++ N +YFKG+W KF Sbjct: 124 SNQADFQSKAVEVIAEVNSWAEKETNGLITEVLPEGSADSMTKLIFANALYFKGTWNEKF 183 Query: 304 PVEMTHNHNFRLNEREVVKVSMM-QTKGNFLAANDQELDCDILQLEY-----VGGISMLI 357 +T F L + V M K +++A D +L L Y SM Sbjct: 184 DESLTQEGEFHLLDGNKVTAPFMTSKKKQYVSAYD---GFKVLGLPYLQGQDKRQFSMYF 240 Query: 358 VVPHKMSGMKTLEAQL--TPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIR 415 +P +G+ L ++ TP ++ + RE +PKFK ++ LK +G+ Sbjct: 241 YLPDANNGLSDLLDKIVSTPGFLDNHIPRRQVKVREFKIPKFKFSFGFDASNVLKGLGLT 300 Query: 416 MLFDKNGNMAGISD-----QRIAIDLFKHQGTITVNEEGTQATTVTTV-----GFMPLST 465 F + + + + + + H+ I VNEEGT+A + G + Sbjct: 301 SPFSGEEGLTEMVESPEMGKNLCVSNIFHKACIEVNEEGTEAAAASAGVIKLRGLLMEED 360 Query: 466 QVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496 ++ F D PFL ++ E+ T +LF+G+V +P Sbjct: 361 EIDFVADHPFLLVVTENITGVVLFIGQVVDP 391 >3PZF-A nrPDB Length = 397 Score = 320 bits (821), Expect = 7e-88, Method: Composition-based stats. Identities = 83/400 (20%), Positives = 168/400 (42%), Gaps = 33/400 (8%) Query: 115 QLFHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMI------SLG 168 Q HG + QR N + F +++ N N+ ++P + + +I S G Sbjct: 11 QDVHGPFQGQRQNEFDLMFVKEIFK------NHNSNVVLSPFSVKILLTLIYEASDTSFG 64 Query: 169 -LKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQ 227 T ++ S++ + + + +++L + N Y L + ++ Sbjct: 65 NAVSNTKRELSSVIQNDNIDH---------TRSYYKQLLESAQQDNKDYDLNIATNFFVD 115 Query: 228 KQFPILLDFKTKVREYYFAEAQIADFSDPAF-ISKTNNHIMKLTKGLIKDAL-ENIDPAT 285 ++ ++ +Y A + +S+P + NN + + T G +++ + + Sbjct: 116 DFIEVINKYQQIANTHYHAMLEKVSYSNPTQTAATINNWVSEHTNGRLREIVTPDSLEGA 175 Query: 286 QMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDIL 345 + ++N IYFKG W FP + F + M+ G F N +L IL Sbjct: 176 VITLVNVIYFKGLWTYPFPEVANNVKPFYGTRGKPTNAQYMEQNGQFYYDNSADLGAQIL 235 Query: 346 QLEYVGG-ISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYN 404 +L Y G ++M ++P+ + + + ++ + + M V LPKFK + + Sbjct: 236 RLPYRGNKLAMYFILPNPDNTVNQVLDRINSASLHQALWYMEENEVNVTLPKFKFDFSEQ 295 Query: 405 LVESLKLMGIRMLFDKNGNMAGISDQR-----IAIDLFKHQGTITVNEEGTQATTVTTVG 459 L E L+ +GIR +F +N ++ ++ R + + + IT+NE G++A T + Sbjct: 296 LNEPLQQVGIREIFSQNASLPLLARGRGARDEVRVSRIFQKAGITINELGSEAYAATEIQ 355 Query: 460 FM---PLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496 + F +RPF+F I + +LF G++ NP Sbjct: 356 LVNKFGGDGVQIFNANRPFIFFIEDETLGTMLFAGKIENP 395 >3OZQ-A nrPDB Length = 376 Score = 313 bits (803), Expect = 9e-86, Method: Composition-based stats. Identities = 95/385 (24%), Positives = 186/385 (48%), Gaps = 28/385 (7%) Query: 121 SRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSI 180 + +Q F ++Y+ + N ++P +T + + G +G+T E++ + Sbjct: 6 ATLQEFPNAVNSFTPSVYKEVLKT--EKANFLVSPFSAATLLALAQSGCRGDTAEEIRQV 63 Query: 181 LHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKV 240 LHF + + + KLT N YTL + N +Y++ F + +F+ Sbjct: 64 LHFVGDREKAEGA----VKEVLSKLT------NEEYTLHTANKIYVKTNFSVREEFQKIA 113 Query: 241 REYYFAEAQIADFSDPAFISK-TNNHIMKLTKGLIKDALEN--IDPATQMMILNCIYFKG 297 E Y A+++ DFS+ +K N + + T+ I++ ++ ++ T+++++N +YF Sbjct: 114 VEVYGAQSENVDFSEKNDAAKLMNAWVEEQTQHKIQNLVDPEILNNLTRVVLINALYFNA 173 Query: 298 SWVNKFPVEMTHNHNFRLNEREVVKVSMMQT-KGNFLAANDQELDCDILQLEYVGGISML 356 W+ FP T +F + +EVV+V M + F LD +L+L + GG S+ Sbjct: 174 KWLVPFPPFHTRKSDFHKSAKEVVQVDTMYLDEQYFNYYECHHLDAKLLELPFKGGASLT 233 Query: 357 IVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRM 416 IV+ +++ G+ +LE+++ + ++T + V LPKFK+E + + LK +G++ Sbjct: 234 IVLSNQIEGLVSLESKIKRSFLPH---NLTKQLVNVALPKFKIESTVDFKKVLKKLGVKK 290 Query: 417 LFDKNGNMAGISDQR--IAIDLFKHQGTITVNEEGTQATTVTTVGFMPLS-----TQVRF 469 F +++GI+ ++ + I + I V+EEG +A T + + + +F Sbjct: 291 AFGDEADLSGIAGEKGDLVISNIVQKSFIDVSEEGVEAAAATYIPVILPEMALPDSPKQF 350 Query: 470 TVDRPFLFLIYEHRTSCLLFMGRVA 494 VD PF+F I +LF GRV Sbjct: 351 IVDHPFIFYI--KVKGMILFAGRVT 373 >1K9O-I nrPDB Length = 378 Score = 313 bits (801), Expect = 2e-85, Method: Composition-based stats. Identities = 103/390 (26%), Positives = 187/390 (47%), Gaps = 26/390 (6%) Query: 119 GKSRIQR-LNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQV 177 G++ +Q+ L N +F ++ + + N N+ ++ + +G ++L GE+H+++ Sbjct: 3 GETDLQKILRESNDQFTAQMFSEVV-KANPGQNVVLSAFSVLPPLGQLALASVGESHDEL 61 Query: 178 HSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFK 237 L + ++F L R R G L+ + +Y+ K + DF Sbjct: 62 LRALALPN---------DNVTKDVFADLN-RGVRAVKGVDLKMASKIYVAKGLELNDDFA 111 Query: 238 TKVREYYFAEAQIADFSDPAFIS-KTNNHIMKLTKGLIKDALEN--IDPATQMMILNCIY 294 R+ + +E Q DF + N + T IK+ ++ +D T+ +++N IY Sbjct: 112 AVSRDVFGSEVQNVDFVKSVEAAGAINKWVEDQTNNRIKNLVDPDALDETTRSVLVNAIY 171 Query: 295 FKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGG-I 353 FKGSW +KF E T + +F +++ + +KV M K + A+ ELD ++++ Y G Sbjct: 172 FKGSWKDKFVKERTMDRDFHVSKDKTIKVPTMIGKKDVRYADVPELDAKMIEMSYEGDQA 231 Query: 354 SMLIVVPHKMSGMKTLEAQLT-PRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLM 412 SM+I++P+++ G+ LE +L P+ + R ++ + N E+ LPKFK+E +L E L M Sbjct: 232 SMIIILPNQVDGITALEQKLKDPKALSRAEERLYNTEVEITLPKFKIETTTDLKEVLSNM 291 Query: 413 GIRMLFDKNG----NMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQ-- 466 I+ LF N+ + + + +D + I VNEEG +A G +P S Sbjct: 292 NIKKLFTPGAARLENLLK-TKESLTVDAAIQKAFIEVNEEGAEAAAANAFGIVPKSLILY 350 Query: 467 VRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496 +DRPF F + +F G+V P Sbjct: 351 PEVHIDRPFYFEL--KIDGIPMFNGKVIEP 378 >6CJ7-A nrPDB Length = 390 Score = 311 bits (798), Expect = 3e-85, Method: Composition-based stats. Identities = 88/380 (23%), Positives = 171/380 (45%), Gaps = 23/380 (6%) Query: 128 ILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFV 187 + F N+++ + + + N+ +P I+ + M+ G G T +++ L Sbjct: 15 PASTSFGVNVFKQMATEQS--GNLAASPFSITILLAMLQQGAAGNTLDEITRALQMTPEK 72 Query: 188 NASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAE 247 +A +F+K+ + +RN L++ N++++ + F + FK + ++ Sbjct: 73 SA----------EIFKKVNEEIQKRNSRNILKTANNVFLSENFNLNPQFKRIAVNNFDSD 122 Query: 248 AQIADFSDPA-FISKTNNHIMKLTKGLIKDAL--ENIDPATQMMILNCIYFKGSWVNKFP 304 F PA N+ I T I + +++ TQM+++N +YFKG W F Sbjct: 123 LTPTYFGKPALAAQNINSWIASKTNDKIDKLVSPDDLSGNTQMVMVNAVYFKGLWEIPFR 182 Query: 305 VEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYV-GGISMLIVVPHKM 363 + T NF LN E S MQT+ F A + ++ L + S+++V+P K Sbjct: 183 EQATQKRNFTLNGGEKKVASFMQTRRYFKAGTHKPAMAKVVVLPFEYNEYSLIVVLPLKS 242 Query: 364 SGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNG- 422 S + L + L+ V + + + + LPKF ++ + NL L MG+ +F + Sbjct: 243 SNVDALLSSLSMEDVASFLD-LPPKDVALELPKFSIKADINLEPVLNKMGVSSIFTQQAE 301 Query: 423 --NMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLS---TQVRFTVDRPFLF 477 N+ + H +T++E G A T+ + LS + F ++PFL Sbjct: 302 LYNLGSHGSLSPQVSSALHSAVLTIDERGGSAAAATSFAAVALSYDEPSLYFRANKPFLA 361 Query: 478 LIYEHRTSCLLFMGRVANPS 497 +++++R+S LFM R+ +P+ Sbjct: 362 ILWDNRSSIPLFMARIMDPT 381 >3STO-A nrPDB Length = 406 Score = 309 bits (793), Expect = 1e-84, Method: Composition-based stats. Identities = 89/397 (22%), Positives = 176/397 (44%), Gaps = 31/397 (7%) Query: 118 HGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMI--SLGLKGETHE 175 H L+ + A F DN P+GI +G++ S G +G T Sbjct: 19 HKAFTHAYLSTVTADFG-------------GDNFLTCPLGILFTLGILLGSGGAQGRTGY 65 Query: 176 QVHSILHFKDFVNASSKYEITT-IHNLFRKLTHRLFRRN------FGYTLRSVNDLYIQK 228 Q+ + K ++ + E + +L+++L + L +R ++++K Sbjct: 66 QIGKTMRLKSTSSSWNSSEAQQEMKSLYQELNNSLTSEKTFLNEKEENVVRISTGIFVEK 125 Query: 229 QFPILLDFKTKVREYYFAEAQIADFSDPAFIS-KTNNHIMKLTKGLIKDAL-ENIDPATQ 286 + + F + E + DFS+ + N+ + + + GL++ ++I T Sbjct: 126 TYEVERRFNESIANDSEGELKQVDFSNRTSATVDINDWVDQQSNGLLEKFFTDDIPDDTA 185 Query: 287 MMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQ 346 M+++N YF+ W + F T +F ++ + V MM +G ++ +I+ Sbjct: 186 MILVNVFYFRDFWQSPFEPHYTRKEDFYISPDRQITVDMMTQEGVMKYGKFEDEGFEIVS 245 Query: 347 LEYVGG-ISMLIVVPHKMSGMKTLEAQLT-PRVVERWQKSMTNRTREVLLPKFKLEKNYN 404 + +IV+P + + L +V+ + K++ T + LPKF L+ + Sbjct: 246 KPLNNTRFTFVIVLPLEKWSLNGATELLNGNKVLSEYVKNLKETTVSLRLPKFTLKNTLD 305 Query: 405 LVESLKLMGIRMLFDK-NGNMAGIS-DQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMP 462 LV +LK +G+ LFD +++GI+ + + ++ F + +NE G +ATTVT+ F+P Sbjct: 306 LVPTLKSIGVVDLFDPVKSDLSGITPNPNLYVNEFIQTNVLKLNESGIEATTVTSPIFVP 365 Query: 463 LS---TQVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496 S +V F V PF+ IY+ + + + +V NP Sbjct: 366 FSAIIPEVDFHVTHPFICFIYDQQLTMPIMAAKVMNP 402 >2PEF-A nrPDB Length = 373 Score = 305 bits (781), Expect = 3e-83, Method: Composition-based stats. Identities = 86/373 (23%), Positives = 154/373 (41%), Gaps = 21/373 (5%) Query: 130 NAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNA 189 A F+ L++ + ++ +N I+P+ A+ M + G ET Q+ L + Sbjct: 13 TADFSIELFK---NSIDDKENSLISPLSAMLALAMTANGADNETLAQMEKALGKDISIED 69 Query: 190 SSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQ 249 +KY T + L + +L N + + + F DF + +YY A+ Sbjct: 70 LNKYLYTYMKKLPNEEKSKLTIANSIW--------FKENDFMPSKDFLQIIADYYKADIF 121 Query: 250 IADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTH 309 A F D + +S NN + T G+I L IDP M ++N + F W + H Sbjct: 122 KAAF-DSSTVSDINNWVKSKTNGMIDKILNKIDPEDVMYLINAVAFDAEWETVYEKASVH 180 Query: 310 NHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTL 369 F KV M ++ N ++E ++ S + ++P + + Sbjct: 181 EDIFTDVYGNRQKVEFMNSEENLYI--EEENAVGFVKPYAKNHYSFVAILPDENISVNEY 238 Query: 370 EAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKN-GNMAGIS 428 LT + K+ LPKFK E + E+L+ +G+ F + + + + Sbjct: 239 IKTLTGQKFIDLIKNAKITLVRASLPKFKYEYTIKMNETLESLGMTDAFLPDKADFSKLG 298 Query: 429 D---QRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRF---TVDRPFLFLIYEH 482 + I H+ I+V+E GT+A VT+V V F ++RPF+F I ++ Sbjct: 299 KSDIGNLYISEVLHKTFISVDELGTKAGAVTSVDITAAGIPVNFKTVKLNRPFIFAIIDN 358 Query: 483 RTSCLLFMGRVAN 495 T+ +F+G V + Sbjct: 359 STNLPIFIGTVLS 371 >1SEK-A nrPDB Length = 378 Score = 300 bits (768), Expect = 1e-81, Method: Composition-based stats. Identities = 100/390 (25%), Positives = 185/390 (47%), Gaps = 26/390 (6%) Query: 119 GKSRIQR-LNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQV 177 G++ +Q+ L N +F ++ + + N N+ ++ + +G ++L GE+H+++ Sbjct: 3 GETDLQKILRESNDQFTAQMFSEVV-KANPGQNVVLSAFSVLPPLGQLALASVGESHDEL 61 Query: 178 HSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFK 237 L + ++F L R R G L+ + +Y+ K + DF Sbjct: 62 LRALALPN---------DNVTKDVFADLN-RGVRAVKGVDLKMASKIYVAKGLELNDDFA 111 Query: 238 TKVREYYFAEAQIADFSDPAFIS-KTNNHIMKLTKGLIKDALEN--IDPATQMMILNCIY 294 R+ + +E Q DF + N + T IK+ ++ +D T+ +++N IY Sbjct: 112 AVSRDVFGSEVQNVDFVKSVEAAGAINKWVEDQTNNRIKNLVDPDALDETTRSVLVNAIY 171 Query: 295 FKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGG-I 353 FKGSW +KF E T + +F +++ + +KV M K + A+ ELD ++++ Y G Sbjct: 172 FKGSWKDKFNKERTMDRDFHVSKDKTIKVPTMIGKKDVRYADVPELDAKMIEMSYEGDQA 231 Query: 354 SMLIVVPHKMSGMKTLEAQLT-PRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLM 412 SM+I++P+++ G+ LE +L P+ + R ++ + N E+ LPKFK+E +L E L M Sbjct: 232 SMIIILPNQVDGITALEQKLKDPKALSRAEERLYNTEVEIYLPKFKIETTTDLKEVLSNM 291 Query: 413 GIRMLFDKNG----NMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLS--TQ 466 I+ LF N+ + + + +D + I VNEEG +A S Sbjct: 292 NIKKLFTPGAARLENLLK-TKESLYVDAAIQKAFIEVNEEGAEAAAANAFKITTYSFHFV 350 Query: 467 VRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496 + +++PF F + +R S F G P Sbjct: 351 PKVEINKPFFFSLKYNRNSM--FSGVCVQP 378 >2OAY-A nrPDB Length = 390 Score = 294 bits (754), Expect = 5e-80, Method: Composition-based stats. Identities = 81/377 (21%), Positives = 160/377 (42%), Gaps = 26/377 (6%) Query: 126 LNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKD 185 L F+ LY N+ +P I++ + + LG T + SIL + Sbjct: 32 LGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYP- 90 Query: 186 FVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYF 245 + T +H + T + + SV+ ++ I F R Y Sbjct: 91 -------KDFTCVHQALKGFTTK--------GVTSVSQIFHSPDLAIRDTFVNASRTLYS 135 Query: 246 AEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPV 305 + ++ + A + N + K T I L+++ T++++LN IY W F Sbjct: 136 SSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWKTTFDP 195 Query: 306 EMTHNHNFRLNEREVVKVSMMQTKGNFLAAN-DQELDCDILQLEYVGGISMLIVVPHKMS 364 + T F + V+KV MM +K +A DQ L + QL+ +S++I+VP + Sbjct: 196 KKTRMEPFHF-KNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLK 254 Query: 365 G-MKTLEAQLTPRVVERWQKSMTNRTRE---VLLPKFKLEKNYNLVESLKLMGIRMLFDK 420 ++ +E L+P V + + + + + LP+ K+ + +++ ++ + F Sbjct: 255 HRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFD-FSY 313 Query: 421 NGNMAGIS-DQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLI 479 + N+ G++ D + + +HQ + + E G + T + F V +PFLF++ Sbjct: 314 DLNLCGLTEDPDLQVSAMQHQTVLELTETGVE--AAAASAISVARTLLVFEVQQPFLFML 371 Query: 480 YEHRTSCLLFMGRVANP 496 ++ + +FMGRV +P Sbjct: 372 WDQQHKFPVFMGRVYDP 388 >1C8O-A nrPDB Length = 300 Score = 292 bits (747), Expect = 3e-79, Method: Composition-based stats. Identities = 86/328 (26%), Positives = 161/328 (49%), Gaps = 33/328 (10%) Query: 135 FNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYE 194 +++R + + +N+FI+P IS+ + ++ G G T EQ+ + + N Sbjct: 1 MDIFREIASSMK-GENVFISPPSISSVLTILYYGANGSTAEQLSKYVEKEADKN------ 53 Query: 195 ITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFS 254 + +S+N +Y + F K+ + + Q DF+ Sbjct: 54 ------------------KDDISFKSMNKVYGRYSAVFKDSFLRKIGDNF----QTVDFT 91 Query: 255 DPAFISKTNNHIMKLTKGLIKDALEN-IDPATQMMILNCIYFKGSWVNKFPVEMTHNHNF 313 D + N + T+G I L+ + P T ++ ++ +YFK W+ F E T ++ F Sbjct: 92 DSRTVDAINKSVDIFTEGKINPLLDEPLSPDTSLLAISAVYFKAKWLMPFEKEFTSDYPF 151 Query: 314 RLNEREVVKVSMMQTKGN-FLAANDQE--LDCDILQLEYVGGISMLIVVPHKMSGMKTLE 370 ++ E+V VSMM G F A+ +E + I++L YVG SM++++P + G++++E Sbjct: 152 YVSPTEMVDVSMMSMYGEAFNHASVKESFGNFSIIELPYVGDTSMVVILPDNIDGLESIE 211 Query: 371 AQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQ 430 LT ++W SM +V +PKFK+ +YNLV++L +G+ +F G+ + +S+ Sbjct: 212 QNLTDTNFKKWSDSMDAMFIDVHIPKFKVTGSYNLVDALVKLGLTEVFGSTGDYSNMSNS 271 Query: 431 RIAIDLFKHQGTITVNEEGTQATTVTTV 458 +++D H+ I VNEE T+A T+ Sbjct: 272 DVSVDAMIHKTYIDVNEEYTEAAAATSA 299 >1JJO-C nrPDB Length = 261 Score = 276 bits (707), Expect = 1e-74, Method: Composition-based stats. Identities = 72/261 (27%), Positives = 134/261 (51%), Gaps = 11/261 (4%) Query: 213 NFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDP-AFISKTNNHIMKLTK 271 Y ++ N L++Q F + +F ++ Y+ AE DFS A + N + T Sbjct: 1 ENQYVMKLANSLFVQNGFHVNEEFLQMLKMYFNAEVNHVDFSQNVAVANSINKWVENYTN 60 Query: 272 GLIKDAL--ENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTK 329 L+KD + E+ D T + ++N +YFKG+W ++F E T +F ++ V++ MM + Sbjct: 61 SLLKDLVSPEDFDGVTNLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQ 120 Query: 330 GNFLAANDQELD------CDILQLEYVGG-ISMLIVVPHKMSGMKTLEAQLTPRVVERWQ 382 G F + +L++ Y G ISM++ + + + TLE L +++E W Sbjct: 121 GEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLALSRQEVPLATLEPLLKAQLIEEWA 180 Query: 383 KSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQR-IAIDLFKHQG 441 S+ + EV LP+F +E+ +L + LK +G+ +F K+ N+ +SD++ + + H+ Sbjct: 181 NSVKKQKVEVYLPRFTVEQEIDLKDILKALGVTEIFIKDANLTAMSDKKELFLSKAVHKS 240 Query: 442 TITVNEEGTQATTVTTVGFMP 462 I VNEEG++A + + + Sbjct: 241 CIEVNEEGSEAAAASGMIAIS 261 >1SNG-A nrPDB Length = 370 Score = 274 bits (701), Expect = 5e-74, Method: Composition-based stats. Identities = 85/374 (22%), Positives = 163/374 (43%), Gaps = 35/374 (9%) Query: 132 KFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASS 191 +FA +L+R L + V + I+ +P ++ A+G+++ G + + Sbjct: 16 EFALHLHRRLAEAVPDGEVIW-SPYSVACALGVLAAGAR---------ATTRTELTTLLG 65 Query: 192 KYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIA 251 + L R +T L S L++ P+ F+ + + ++ + A Sbjct: 66 TDPAPLLAALDRAVT-------DSPDLASRTVLWVSADVPVRSSFRATMHDRPDSDVRTA 118 Query: 252 DF-SDPAFISKT-NNHIMKLTKGLIKDALEN--IDPATQMMILNCIYFKGSWVNKFPVEM 307 DF ++P + T N I T+G+I++ L + P + ++ N ++ K W F + Sbjct: 119 DFRTNPEGVRATVNADIADATRGMIRELLPQGAVTPDLRAILTNALWAKARWTTPFEAHL 178 Query: 308 THNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMK 367 T FR R +V M A + ++ L +++ +++P G Sbjct: 179 TRAGTFR-TPRGPKRVPFMHRTKTMPYATAR--GWRMVTLHAHDELAVDVLLP---PGTN 232 Query: 368 TLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGI 427 P + ++S + + E+ LP+F+L + + LVE L G+R LF + +++GI Sbjct: 233 AAAVPTAPLLTALHRRSAS-TSVELALPRFELTQPHQLVEVLAEAGVRTLFTASADLSGI 291 Query: 428 SDQRIAIDLFKHQGTITVNEE-----GTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEH 482 S + +D HQ + V+E A + G MP +RF+VDRPF ++ Sbjct: 292 STVPLYVDTVIHQARLRVDERGAEGAAATAAMMLLAGAMPPRRTIRFSVDRPFHIVVR-- 349 Query: 483 RTSCLLFMGRVANP 496 R +LF+G +A+P Sbjct: 350 RRGAILFLGSIADP 363 >1M93-B nrPDB Length = 245 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 73/246 (29%), Positives = 133/246 (54%), Gaps = 8/246 (3%) Query: 217 TLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKD 276 + +S+N +Y + F K+ + + Q DF+D + N + T+G I Sbjct: 3 SFKSMNKVYGRYSAVFKDSFLRKIGDNF----QTVDFTDSRTVDAINKSVDIFTEGKINP 58 Query: 277 ALEN-IDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGN-FLA 334 L+ + P T ++ ++ +YFK W+ F E T ++ F ++ E+V VSMM G F Sbjct: 59 LLDEPLSPDTSLLAISAVYFKAKWLMPFEKEFTSDYPFYVSPTEMVDVSMMSMYGEAFNH 118 Query: 335 ANDQE--LDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREV 392 A+ +E + I++L YVG SM++++P + G++++E LT ++W SM +V Sbjct: 119 ASVKESFGNFSIIELPYVGDTSMVVILPDNIDGLESIEQNLTDTNFKKWSDSMDAMFIDV 178 Query: 393 LLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQA 452 +PKFK+ +YNLV++L +G+ +F G+ + +S+ +++D H+ I VNEE T+A Sbjct: 179 HIPKFKVTGSYNLVDALVKLGLTEVFGSTGDYSNMSNSDVSVDAMIHKTYIDVNEEYTEA 238 Query: 453 TTVTTV 458 T+ Sbjct: 239 AAATSA 244 >2WXZ-C nrPDB Length = 453 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 75/386 (19%), Positives = 150/386 (38%), Gaps = 14/386 (3%) Query: 122 RIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSIL 181 R ++ ++ F +Y++L + ++P + + LG T Q+ +L Sbjct: 69 RAAQVAMIANFMGFRMYKMLSEARGVASGAVLSPPALFGTLVSFYLGSLDPTASQLQVLL 128 Query: 182 HFK----DFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTL--RSVNDLYIQKQFPILLD 235 D + +++ T + L + L +V L+ + Sbjct: 129 GVPVKEGDCTSRLDGHKVLTALQAVQGLLVTQGGSSSQTPLLQSTVVGLFTAPGLRLKQP 188 Query: 236 FKTKVREYYFAE-AQIADFS-DPA-FISKTNNHIMKLTKGLIKDALENIDPATQMMILNC 292 F + + A + D S DP K N + +T + LE + + + Sbjct: 189 FVESLGPFTPAIFPRSLDLSTDPVLAAQKINRFVQAVTGWKMNLPLEGVSTDSTLFFNTY 248 Query: 293 IYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGG 352 ++F+G + F ++T H F ++ V V M+ GNF +D + + + ++ Sbjct: 249 VHFQGK-MRGF-SQLTGLHEFWVDNSTSVSVPMLSGTGNFQHWSDAQNNFSVTRVPLGES 306 Query: 353 ISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLM 412 +++L++ P S + +E + W K+ R + LP+ ++ +YNL + L Sbjct: 307 VTLLLIQPQCASDLDRVEVLVFQHDFLTWIKNPPPRAIRLTLPQLEIRGSYNLQDLLAQA 366 Query: 413 GIRMLFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQV-RFTV 471 + L N+ + D + + + + + + T P S +V T+ Sbjct: 367 KLSTLLGAEANLGKMGDTNPRVGEVLNSILLEL--QAGEEEQPTESAQQPGSPEVLDVTL 424 Query: 472 DRPFLFLIYEHRTSCLLFMGRVANPS 497 PFLF IYE + L F+GRV NP Sbjct: 425 SSPFLFAIYERDSGALHFLGRVDNPQ 450 >1MTP-A nrPDB Length = 323 Score = 243 bits (620), Expect = 2e-64, Method: Composition-based stats. Identities = 68/321 (21%), Positives = 137/321 (42%), Gaps = 28/321 (8%) Query: 132 KFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASS 191 +FA +L+R L + V + I+ +P ++ A+G+++ G + + Sbjct: 12 EFALHLHRRLAEAVPDGEVIW-SPYSVACALGVLAAGAR---------ATTRTELTTLLG 61 Query: 192 KYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIA 251 + L R +T L S L++ P+ F+ + + ++ + A Sbjct: 62 TDPAPLLAALDRAVT-------DSPDLASRTVLWVSADVPVRSSFRATMHDRPDSDVRTA 114 Query: 252 DF-SDPAFISKT-NNHIMKLTKGLIKDALEN--IDPATQMMILNCIYFKGSWVNKFPVEM 307 DF ++P + T N I T+G+I++ L + P + ++ N ++ K W F + Sbjct: 115 DFRTNPEGVRATVNADIADATRGMIRELLPQGAVTPDLRAILTNALWAKARWTTPFEAHL 174 Query: 308 THNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMK 367 T FR R +V M A + ++ L +++ +++P G Sbjct: 175 TREGTFR-TPRGPKRVPFMHRTKTMPYATAR--GWRMVTLHAHDELAVDVLLP---PGTN 228 Query: 368 TLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGI 427 P + ++S + + E+ LP+F+L + + LVE L G+R LF + +++GI Sbjct: 229 AAAVPTAPLLTALHRRSAS-TSVELALPRFELTQPHQLVEVLAEAGVRTLFTASADLSGI 287 Query: 428 SDQRIAIDLFKHQGTITVNEE 448 S + +D HQ + V+E Sbjct: 288 STVPLYVDTVIHQARLRVDER 308 >2WXX-A nrPDB Length = 453 Score = 241 bits (615), Expect = 6e-64, Method: Composition-based stats. Identities = 82/405 (20%), Positives = 157/405 (38%), Gaps = 19/405 (4%) Query: 105 DSDVSAGNILQLFHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGM 164 D V A L+ + R ++ ++ F +Y++L + + ++P + + Sbjct: 53 DQLVLAAEKLED-EDRKRAAQVAMITNFVGFRMYKMLNEAGSGASGAILSPPALFGTLVS 111 Query: 165 ISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKL--------THRLFRRNFGY 216 LG T Q+ ++L V H + L T Sbjct: 112 FYLGSLDPTASQLQTLL--DVPVKEGDCTSRLDGHKVLAALRAVQGLLVTQGGSSSQTPL 169 Query: 217 TLRSVNDLYIQKQFPILLDFKTKVREYYFAE-AQIADFS-DPAFI-SKTNNHIMKLTKGL 273 V L+ F + F + + A + D S DP K N I +T Sbjct: 170 LQSIVVGLFTAPGFRLKHSFVQSLALFTPALFPRSLDLSTDPVLATEKINRFIKAVTGWK 229 Query: 274 IKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFL 333 + LE + + ++ ++F+G+ + F ++ H F ++ V V M+ GNF Sbjct: 230 MNLPLEGVSTDSTLLFNTYVHFQGT-MRGF-SQLPGVHEFWVDNSISVSVPMISGTGNFQ 287 Query: 334 AANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVL 393 +D + + + + ++L++ PH +S + +EA + + W ++ R + Sbjct: 288 HWSDAQNNFSVTCVPLGERATLLLIQPHCISDLDRVEALIFQNDLLTWIENPPPRAIRLT 347 Query: 394 LPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQAT 453 LP+ ++ +YNL + L + L N+ I D + + + + + + Sbjct: 348 LPQLEIRGSYNLQDLLAEDKLPTLLGAEANLNNIGDTNPRVGEVLNSILLEL--KAGEEE 405 Query: 454 TVTTVGFMPLSTQ-VRFTVDRPFLFLIYEHRTSCLLFMGRVANPS 497 TT P S + + T+ PFLF IYE + L F+GRV NP Sbjct: 406 QPTTSVQQPGSPEALDVTLSSPFLFAIYEQDSGTLHFLGRVNNPQ 450 >6BJ5-B nrPDB Length = 315 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 62/319 (19%), Positives = 126/319 (39%), Gaps = 38/319 (11%) Query: 146 NTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKL 205 N DN+ +P G+++A+ ++ + G T ++ + + F L Sbjct: 28 NESDNVVFSPYGLTSALSVLRIAAGGNTKREID------------VPESVVEDSDAFLAL 75 Query: 206 THRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTNNH 265 L++ P+ +F + + Q F+ N++ Sbjct: 76 RE----------------LFVDASVPLRPEFTAEFSSRFNTSVQRVTFNSENVKDVINSY 119 Query: 266 IMKLTKGLIKDALE-NIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVS 324 + T G + L+ ++D T+M++L+ + K SW + F T + F + KV Sbjct: 120 VKDKTGGDVPRVLDASLDRDTKMLLLSSVRMKTSWRHVFDPSFTTDQPFY-SGNVTYKVR 178 Query: 325 MMQTKGNFLAAND--QELDCDILQLEYVG-GISMLIVVPHKMSGMKTLEAQLTPRVVERW 381 MM + + + +L Y +ML+VVP + + L +V W Sbjct: 179 MMNKIDTLKTETFTLRNVGYSVTELPYKRRQTAMLLVVPDD---LGEIVRALDLSLVRFW 235 Query: 382 QKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKN-GNMAGISDQR-IAIDLFKH 439 ++M +V++PKF +E +L ++L+ +G+R FD + + S + + Sbjct: 236 IRNMRKDVCQVVMPKFSVESVLDLRDALQRLGVRDAFDPSRADFGQASPSNDLYVTKVLQ 295 Query: 440 QGTITVNEEGTQATTVTTV 458 I +E GT A++ T + Sbjct: 296 TSKIEADERGTTASSDTAI 314 >5M3Y-A nrPDB Length = 458 Score = 231 bits (590), Expect = 4e-61, Method: Composition-based stats. Identities = 65/353 (18%), Positives = 141/353 (39%), Gaps = 12/353 (3%) Query: 152 FIAPVGISTAMGMISLGLKGETHEQVHSILH----FKDFVNASSKYEITTIHNLFRKLTH 207 ++P + + + LG T +++ +IL K + +++ + + L Sbjct: 100 VLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKQCTSRLDAHKVLSALQAVQGLLV 159 Query: 208 RLFRRNFGYTLRSVN--DLYIQKQFPILLDFKTKVREY-YFAEAQIADFSD-PAFISKTN 263 R + L ++ + F + Y + DF++ K + Sbjct: 160 AQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLDFTELDVAAEKID 219 Query: 264 NHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKV 323 + +T +L + + ++F+G + F + + F +++ V V Sbjct: 220 RFMQAVTGWKTGSSLMGASVDSTLAFNTYVHFQGK-MKGFSL-LAEPQEFWVDQSTSVSV 277 Query: 324 SMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQK 383 M+ G F +D + + Q+ + S+L++ PH S + +E + W K Sbjct: 278 PMLSGMGTFQHWSDIQDQFSVTQVPFTESASLLLIQPHYASDLDKVEGLTFQQNSLNWMK 337 Query: 384 SMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKHQGTI 443 ++ RT + +P+ L+ +Y+L + L + + N+ +S+ RI + + Sbjct: 338 KLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIRVGEVLNSIFF 397 Query: 444 TVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 496 + + + T T P + T++RPFLF +Y+ + L F+GRVANP Sbjct: 398 ELEADEREPTESTQQLNKPE--VLEVTLNRPFLFAVYDQSATALHFLGRVANP 448 >5C98-A nrPDB Length = 382 Score = 209 bits (531), Expect = 3e-54, Method: Composition-based stats. Identities = 58/374 (15%), Positives = 140/374 (37%), Gaps = 26/374 (6%) Query: 128 ILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFV 187 N KF ++ D+ N ++P + A+ M E + Sbjct: 19 AANNKFTLEYFKACYDEKC---NCAVSPYHVRLALSMFYPLAGAAVQEDFQVAFGLPE-- 73 Query: 188 NASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAE 247 +H + + + G L++++ + +++ + +F+ + Sbjct: 74 ---------DVHAAIEQQQRLAQQLHDGQHLKALSFVLVEETLRLDSEFERLFHRTFQTT 124 Query: 248 AQIADFSDPAFISKTNNHIMKLTKGLIKDALE-----NIDPATQMMILNCIYFKGSWVNK 302 + D +D + N + I+D + ++ P ++M+ + + + Sbjct: 125 VEPVDLTDDIPSALAVNSFYQRANTEIEDFIGEGDVFSLPPCHKLMLFSGVSVLTPLAIR 184 Query: 303 FPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEY--VGGISMLIVVP 360 F T F+ +VS M T EL C ++ + + G+SML+++P Sbjct: 185 FNPADTALELFQFINAPTQRVSTMHTTAFVRRCLHNELRCKVVDMPFDAASGLSMLVLLP 244 Query: 361 HKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDK 420 + + ++ + +TP + + + + + ++ LPKF + + + ++L +G +F+ Sbjct: 245 YDGTELRQIVNSITPAHLAQIDERLQSCWTDLKLPKFFVREKTDPKQTLGKLGYGGVFEI 304 Query: 421 NGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIY 480 + R ++ F + V+E G+ ++ F +RPF+FLI Sbjct: 305 DDLHVFHDSGRTRLNGFIQHCYLAVSESGSGIPAPPDTP-----SEFEFHANRPFMFLIR 359 Query: 481 EHRTSCLLFMGRVA 494 +L +G + Sbjct: 360 RTMDGNVLQVGNFS 373 >4R9I-A nrPDB Length = 378 Score = 91.2 bits (225), Expect = 1e-18, Method: Composition-based stats. Identities = 53/365 (14%), Positives = 129/365 (35%), Gaps = 33/365 (9%) Query: 144 QVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFR 203 Q N F + + +SL K +T +++ L+ + + + Sbjct: 34 QYEPERNQFSTAFPLLFMLSELSLNSKEDTTAELYKNLNLRSEDEVVNVN---------Q 84 Query: 204 KLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTN 263 + L +N Y + + Y P F + + + D+S+ A + Sbjct: 85 AVNTNLNTKNEVYQSTLILNAYTDIDSPFSETFIQNFAKVFNGTVKNIDYSNDAVAT-IR 143 Query: 264 NHIMKLTKGLIKDALEN--IDPATQMMILNC--IYFKGSWVNKFPVEMTHNH---NFRLN 316 + + + I+ AL++ I+ T +++ IYF W + +F Sbjct: 144 DSLQSDSGNDIEIALKDGDINKDTGIILTAYTNIYF--PWGEASDSYRPYKQIDISFTAL 201 Query: 317 EREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVP-HKMSGMKTLEAQL-T 374 + ++G A + L + Q G+++++ + + + +L Sbjct: 202 DGTQSNKQAWYSEGAGKYAEIENLGIKVFQFSLKPGLTVVLGTSLNDNNDLSGAFNKLRD 261 Query: 375 PRVVERWQKSMTNRTREVLLP-KFKLEKNYNLVESLKLMGI-RMLFDKNGNM--AGISDQ 430 P + ++ ++ +P + + + + + +K G+ LF+KN + ++ Sbjct: 262 PATLAYILTQTESKYLKLAVPIELTMRDSRDYIPEVKRAGLLTELFEKNFDGFDTVYDNK 321 Query: 431 RIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFM 490 I + E+ T+ + V + F D+P+ FL+ + + F+ Sbjct: 322 SGYISYMLSHTRLEF-EQPTEEQAASVV------AEPDFIFDKPYFFLVLDQF-NTPAFI 373 Query: 491 GRVAN 495 G + N Sbjct: 374 GLITN 378 >4I9T-A nrPDB Length = 310 Score = 34.2 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 24/115 (20%), Positives = 40/115 (34%), Gaps = 19/115 (16%) Query: 174 HEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFR------------RNFGYTLRSV 221 Q+ S + F D +S + ++H+ L H L + N + Sbjct: 54 LTQMKSGVRFFDIRGRASADNMISVHHGMVYLHHELGKFLDDAKYYLSAYPNETIVMSMK 113 Query: 222 NDLYIQKQFPILLDFKTKVREYYFAEAQIAD-FSDPAFISKTNNHIMKLTKGLIK 275 D + F+ REYY+ Q + F + + T +K TKG I Sbjct: 114 KD--YDSDSKVTKTFEEIFREYYYNNPQYQNLFYTGSNANPT----LKETKGKIV 162 >4P2L-A nrPDB Length = 506 Score = 31.9 bits (71), Expect = 0.65, Method: Composition-based stats. Identities = 11/70 (15%), Positives = 22/70 (31%), Gaps = 21/70 (30%) Query: 228 KQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQM 287 ++ L F + +Y+ + + +F + N+ + K K I Sbjct: 285 QRLVALKKFVAVLAKYFPGQPLVQNF-----LHSINDWLQKQQKKKIP------------ 327 Query: 288 MILNCIYFKG 297 YFK Sbjct: 328 ----YSYFKA 333 >5W76-A nrPDB Length = 385 Score = 31.9 bits (71), Expect = 0.78, Method: Composition-based stats. Identities = 9/42 (21%), Positives = 17/42 (40%) Query: 443 ITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRT 484 + +EEG +A + +D+PFL I + + Sbjct: 171 LEGDEEGEEAIMKLMDAVDSYIPEPERAIDKPFLMPIEDVFS 212 >4OVR-A nrPDB Length = 322 Score = 31.5 bits (70), Expect = 0.94, Method: Composition-based stats. Identities = 10/40 (25%), Positives = 19/40 (47%) Query: 236 FKTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIK 275 + +R+Y A+ Q AD+ + ++ + K T G I Sbjct: 19 YFQSMRQYRSADVQPADYPTVKAVQSMSDELNKETNGKIS 58 >5NSQ-A nrPDB Length = 521 Score = 29.9 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 10/45 (22%), Positives = 16/45 (35%), Gaps = 10/45 (22%) Query: 439 HQGTITVNEEGTQATTVTT----------VGFMPLSTQVRFTVDR 473 H + VNEEG +A + V + P + F + Sbjct: 413 HHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEYHEPEFKSNH 457 >3T59-A nrPDB Length = 519 Score = 29.9 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 8/48 (16%), Positives = 19/48 (39%), Gaps = 5/48 (10%) Query: 228 KQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIK 275 ++ L F + +Y+ + + +F + N+ + K K I Sbjct: 297 QRLVALKKFVAVLAKYFPGQPLVQNF-----LHSINDWLQKQQKKRIP 339 >3H1Q-A nrPDB Length = 272 Score = 29.9 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 9/43 (20%), Positives = 15/43 (34%), Gaps = 4/43 (9%) Query: 271 KGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNF 313 KG I + T + ++ GS+ F T +F Sbjct: 158 KGKITATFDEPTGGTHLSLVLA----GSYKIPFEEAETIKKDF 196 >2ILV-A nrPDB Length = 400 Score = 29.2 bits (64), Expect = 4.1, Method: Composition-based stats. Identities = 14/64 (21%), Positives = 24/64 (37%), Gaps = 1/64 (1%) Query: 225 YIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPA 284 Y Q+Q +L F + + + F + N++I+ K I + NI Sbjct: 257 YAQQQLNLLNHFTQAEGDLFIGDHYKIYFKGHPRGGEINDYILNNAKN-ITNIPANISFE 315 Query: 285 TQMM 288 MM Sbjct: 316 VLMM 319 >5L7Z-A nrPDB Length = 333 Score = 29.2 bits (64), Expect = 4.3, Method: Composition-based stats. Identities = 16/58 (27%), Positives = 27/58 (46%), Gaps = 5/58 (8%) Query: 97 DSLSVSPTDSDVSAGNILQLFHGKSRIQRL-----NILNAKFAFNLYRVLKDQVNTFD 149 DS+S+SP DS V+ G+ Q + +R + AK AF++ L + + Sbjct: 226 DSVSISPRDSTVTNGDDKQSSKNAVQGKRELFDGNASVRAKLAFDVALQLSNSDGKPE 283 >5T7V-LC nrPDB Length = 214 Score = 28.8 bits (63), Expect = 5.2, Method: Composition-based stats. Identities = 6/37 (16%), Positives = 19/37 (51%) Query: 410 KLMGIRMLFDKNGNMAGISDQRIAIDLFKHQGTITVN 446 + +G+ +F +NG + ++ ++ + T+ V+ Sbjct: 7 RKIGMTQVFGENGELIPVTVVEAKENVVLQKKTVEVD 43 >2P6F-A nrPDB Length = 455 Score = 28.4 bits (62), Expect = 7.2, Method: Composition-based stats. Identities = 17/122 (13%), Positives = 43/122 (35%), Gaps = 19/122 (15%) Query: 207 HRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVR--EYYFAEAQIADF----SDPAFIS 260 + L + LR + I + F + ++++ + + E +F S P Sbjct: 250 NALPAKTKTAGLRKLKKEDIDQVFELFKRYQSRFELIQIFTKEEFEHNFIGEESLPLDKQ 309 Query: 261 KTNNHIMKLTKGLIKDALENID-PATQM-------MILNCIYFKG-----SWVNKFPVEM 307 +++++ G I D P T + + + +Y+ + ++F + Sbjct: 310 VIFSYVVEQPDGKITDFFSFYSLPFTILNNTKYKDLGIGYLYYYATDADFQFKDRFDPKA 369 Query: 308 TH 309 T Sbjct: 370 TK 371 >4YUX-A nrPDB Length = 304 Score = 28.0 bits (61), Expect = 8.7, Method: Composition-based stats. Identities = 10/30 (33%), Positives = 14/30 (46%), Gaps = 1/30 (3%) Query: 235 DFKTKVREYYFAEAQIADFSDPAFISKTNN 264 F ++ YY +E A F+ P F NN Sbjct: 274 PFAKDLK-YYDSEMHKASFALPRFARHINN 302 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.144 0.419 Lambda K H 0.267 0.0445 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 20,785,618 Number of Sequences: 36641 Number of extensions: 885238 Number of successful extensions: 2998 Number of sequences better than 10.0: 78 Number of HSP's better than 10.0 without gapping: 127 Number of HSP's successfully gapped in prelim test: 23 Number of HSP's that attempted gapping in prelim test: 2322 Number of HSP's gapped (non-prelim): 154 length of query: 499 length of database: 10,336,785 effective HSP length: 101 effective length of query: 398 effective length of database: 6,636,044 effective search space: 2641145512 effective search space used: 2641145512 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (28.0 bits)