BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P05181 (493 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3E6I-A nrPDB 962 0.0 4GQS-A nrPDB 585 e-167 5W0C-A nrPDB 573 e-164 2NNH-A nrPDB 570 e-163 1N6B-A nrPDB 561 e-160 2PG7-A nrPDB 471 e-133 5E0E-A nrPDB 464 e-131 5E58-A nrPDB 462 e-130 4H1N-A nrPDB 452 e-127 3IBD-A nrPDB 444 e-125 3TBG-A nrPDB 318 4e-87 3DL9-A nrPDB 288 3e-78 4R20-A nrPDB 237 1e-62 6DWN-A nrPDB 219 2e-57 2HI4-A nrPDB 215 4e-56 6B82-A nrPDB 207 1e-53 6IQ5-A nrPDB 200 9e-52 5UYS-A nrPDB 192 3e-49 3QZ1-A nrPDB 192 4e-49 4R1Z-A nrPDB 187 1e-47 5VBU-A nrPDB 180 1e-45 5YLW-A nrPDB 164 1e-40 6DA2-A nrPDB 110 2e-24 3K9V-A nrPDB 105 5e-23 5VEU-A nrPDB 104 9e-23 3S79-A nrPDB 94 2e-19 6C94-A nrPDB 90 3e-18 2VE3-A nrPDB 87 2e-17 3EL3-A nrPDB 79 5e-15 4KPA-A nrPDB 79 6e-15 6AYB-A nrPDB 75 7e-14 3MDV-A nrPDB 72 8e-13 3MZS-A nrPDB 65 7e-11 3N9Z-A nrPDB 63 3e-10 6M7X-A nrPDB 59 4e-09 4ZGX-A nrPDB 58 1e-08 5VWS-A nrPDB 56 3e-08 2Y5N-A nrPDB 56 3e-08 6B11-A nrPDB 56 3e-08 2W0A-A nrPDB 55 5e-08 3JUS-A nrPDB 55 7e-08 3L4D-A nrPDB 54 1e-07 2WX2-A nrPDB 54 1e-07 3TYW-A nrPDB 54 2e-07 1WIY-A nrPDB 54 2e-07 4TRI-A nrPDB 52 7e-07 5FSA-A nrPDB 51 1e-06 3IVY-A nrPDB 50 2e-06 2X2N-A nrPDB 50 2e-06 3SN5-A nrPDB 50 3e-06 5DQN-A nrPDB 49 4e-06 4WMZ-A nrPDB 49 5e-06 6CR2-A nrPDB 49 5e-06 5YSW-A nrPDB 49 6e-06 2IJ7-A nrPDB 49 6e-06 4YZR-A nrPDB 49 7e-06 2XKR-A nrPDB 48 9e-06 5LIE-A nrPDB 47 2e-05 3MGX-A nrPDB 46 3e-05 4RM4-A nrPDB 46 3e-05 4GGV-A nrPDB 46 3e-05 6GMF-A nrPDB 46 4e-05 6F88-A nrPDB 46 5e-05 3A1L-A nrPDB 45 6e-05 5JLC-A nrPDB 45 6e-05 6GK6-A nrPDB 45 7e-05 5EX6-C nrPDB 45 7e-05 6F0B-A nrPDB 45 7e-05 5Y1I-A nrPDB 45 7e-05 2VZM-A nrPDB 45 8e-05 4WPZ-A nrPDB 45 8e-05 1Q5D-A nrPDB 45 8e-05 2Z36-A nrPDB 44 1e-04 3TKT-A nrPDB 44 1e-04 5NWS-A nrPDB 44 1e-04 4OQR-A nrPDB 44 2e-04 5LIV-A nrPDB 44 2e-04 3WVS-A nrPDB 43 3e-04 5DE9-A nrPDB 43 3e-04 6CVC-A nrPDB 43 3e-04 1UED-A nrPDB 43 3e-04 4OQS-A nrPDB 43 3e-04 6FSH-A nrPDB 43 3e-04 3ABB-A nrPDB 43 4e-04 2RFC-A nrPDB 43 4e-04 6DCD-A nrPDB 43 4e-04 3A50-A nrPDB 42 4e-04 4MM0-A nrPDB 42 4e-04 4TX3-A nrPDB 42 5e-04 3OFT-A nrPDB 42 5e-04 6A7I-A nrPDB 42 5e-04 5M0P-A nrPDB 42 6e-04 6M7L-A nrPDB 42 6e-04 3EJB-B nrPDB 42 8e-04 4UBS-A nrPDB 42 8e-04 5FYF-A nrPDB 42 9e-04 2ZBZ-A nrPDB 42 9e-04 3AWQ-A nrPDB 42 9e-04 2WM5-A nrPDB 41 0.001 5IT1-A nrPDB 41 0.001 5CJE-A nrPDB 40 0.002 5L94-A nrPDB 40 0.002 1LG9-A nrPDB 40 0.003 6A7J-A nrPDB 40 0.003 2X9P-A nrPDB 40 0.003 5L1U-A nrPDB 40 0.003 1Z8P-A nrPDB 39 0.004 5FOI-A nrPDB 39 0.004 2WIO-A nrPDB 39 0.005 5HIW-A nrPDB 39 0.005 4Z5Q-A nrPDB 39 0.006 4YT3-A nrPDB 39 0.006 5GWE-A nrPDB 38 0.011 2IAG-A nrPDB 38 0.012 3RWL-A nrPDB 38 0.012 6GII-A nrPDB 38 0.013 5XJN-A nrPDB 37 0.014 1UE8-A nrPDB 37 0.014 4JBT-A nrPDB 37 0.019 3P3Z-A nrPDB 37 0.021 6G71-A nrPDB 37 0.023 1GWI-A nrPDB 37 0.024 4Z5P-A nrPDB 36 0.032 3ABA-A nrPDB 36 0.032 5HDI-A nrPDB 36 0.035 4PWV-A nrPDB 36 0.044 5KYO-A nrPDB 35 0.056 3NC3-A nrPDB 35 0.074 6FYJ-A nrPDB 35 0.074 3R9C-A nrPDB 35 0.083 5XW2-A nrPDB 34 0.14 5XNT-A nrPDB 34 0.15 2QBO-A nrPDB 33 0.20 5YHJ-A nrPDB 33 0.23 6HQW-A nrPDB 33 0.28 6BLD-A nrPDB 33 0.30 1GCW-B nrPDB 32 0.52 6AGB-C nrPDB 32 0.76 2FR7-A nrPDB 32 0.79 1NLM-A nrPDB 32 0.91 5Y58-A nrPDB 31 1.1 4DO1-A nrPDB 30 1.9 3OO3-A nrPDB 30 2.1 5OFQ-A nrPDB 30 2.9 3P5P-A nrPDB 30 3.0 1GKQ-A nrPDB 30 3.1 2WTB-A nrPDB 30 3.5 1ODO-A nrPDB 29 4.3 2NZA-A nrPDB 29 5.2 3NV6-A nrPDB 28 7.4 2ZQJ-A nrPDB 28 9.4 >3E6I-A nrPDB Length = 476 Score = 962 bits (2488), Expect = 0.0, Method: Compositional matrix adjust. Identities = 464/472 (98%), Positives = 466/472 (98%) Query: 22 MWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81 M ++ S LPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH Sbjct: 1 MAKKTSSKGKLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 60 Query: 82 GYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQ 141 GYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQ Sbjct: 61 GYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQ 120 Query: 142 GNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMY 201 GNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMY Sbjct: 121 GNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMY 180 Query: 202 LFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNC 261 LFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNC Sbjct: 181 LFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNC 240 Query: 262 PRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEI 321 PRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEI Sbjct: 241 PRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEI 300 Query: 322 EEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGY 381 EEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGY Sbjct: 301 EEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGY 360 Query: 382 LIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEG 441 LIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEG Sbjct: 361 LIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEG 420 Query: 442 LARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS 493 LARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS Sbjct: 421 LARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS 472 >4GQS-A nrPDB Length = 477 Score = 585 bits (1508), Expect = e-167, Method: Compositional matrix adjust. Identities = 270/461 (58%), Positives = 356/461 (77%), Gaps = 1/461 (0%) Query: 32 LPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALL 91 LPPGP PLP+IGN+ Q+++K++ KS T L++ +GPVFTLY G +RMVV+HGY+ VKEAL+ Sbjct: 12 LPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALI 71 Query: 92 DYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQRE 150 D +EFSGRG P A A+R GI+F+NG WK+IRRFSL TLRN+GMGK+ E R+Q E Sbjct: 72 DLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEE 131 Query: 151 AHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLL 210 A L+E LRKT+ P DPTF++GCAPCNVI I+F+K FDY D++FL LM NEN ++ Sbjct: 132 ARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIV 191 Query: 211 STPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLL 270 STPW+Q+ NNFP+ + Y PG+H K++KN+A ++ + E+VKEH +S+D N PRD DC L Sbjct: 192 STPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFL 251 Query: 271 VEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEID 330 ++MEKEK + + +T++ + +T ADL AGTETTSTTLRY LL+L+K+PE+ K+ EEI+ Sbjct: 252 IKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIE 311 Query: 331 RVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVV 390 RV+G +R P ++DR MPY DAVVHE+QR+I L+P++LPH T D FR YLIPKGT ++ Sbjct: 312 RVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTIL 371 Query: 391 PTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLL 450 +L SVL+DN+EFP+PE F P HFL+E G FK S+YF PFS GKR+C GEGLARMELFL Sbjct: 372 TSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLF 431 Query: 451 LCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIP 491 L ILQ+FNLK L+DPKD+D +P+ GF +PP Y+LC IP Sbjct: 432 LTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIP 472 >5W0C-A nrPDB Length = 477 Score = 573 bits (1476), Expect = e-164, Method: Compositional matrix adjust. Identities = 271/461 (58%), Positives = 350/461 (75%), Gaps = 1/461 (0%) Query: 32 LPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALL 91 LPPGP PLP+IGN+ Q+ +K+I KS T L++ +GPVFTLY G + +VV+HGY+AVKEAL+ Sbjct: 12 LPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALI 71 Query: 92 DYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQRE 150 D +EFSGRG P A A+R GI+F+NG WK+IRRFSL TLRN+GMGK+ E R+Q E Sbjct: 72 DLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEE 131 Query: 151 AHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLL 210 A L+E LRKT+ P DPTF++GCAPCNVI I+F K FDY D++FL LM NEN +L Sbjct: 132 ARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKIL 191 Query: 211 STPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLL 270 S+PW+Q+ NNF + Y PG+H K++KNVA +K Y+ E+VKEH +S+D N P+D DC L Sbjct: 192 SSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFL 251 Query: 271 VEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEID 330 ++MEKEKH+ +T++ + T DLF AGTETTSTTLRY LL+L+K+PE+ K+ EEI+ Sbjct: 252 MKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIE 311 Query: 331 RVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVV 390 RVIG +R P ++DR MPY DAVVHE+QR+I L+P++LPH T D FR YLIPKGT ++ Sbjct: 312 RVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTIL 371 Query: 391 PTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLL 450 +L SVL+DN+EFP+PE F P HFL+E G FK S YF PFS GKR+C GE LA MELFL Sbjct: 372 ISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLF 431 Query: 451 LCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIP 491 L +ILQ+FNLK LVDPK++D +P+ GF +PP Y+LC IP Sbjct: 432 LTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIP 472 >2NNH-A nrPDB Length = 476 Score = 570 bits (1470), Expect = e-163, Method: Compositional matrix adjust. Identities = 270/471 (57%), Positives = 350/471 (74%), Gaps = 1/471 (0%) Query: 22 MWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81 M ++ S LPPGP PLPIIGN+ Q+++K+I KSFT ++ +GPVFT+Y G +VV H Sbjct: 1 MAKKTSSKGKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFH 60 Query: 82 GYKAVKEALLDYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGK 140 GY+AVKEAL+D +EFSGRG+ P + + GII +NG WK+IRRFSLTTLRN+GMGK Sbjct: 61 GYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGK 120 Query: 141 QGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLM 200 + E R+Q EAH L+E LRKT+ P DPTF++GCAPCNVI ++F+K FDY D+ FL LM Sbjct: 121 RSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLM 180 Query: 201 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 260 FNENF +L++PW+Q+ NNFP + PG+H KV+KNVA + Y+ E+VKEH SLD N Sbjct: 181 KRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVN 240 Query: 261 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 320 PRD DC L++ME+EK + + + ++ + TVADLF AGTETTSTTLRYGLL+L+K+PE Sbjct: 241 NPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPE 300 Query: 321 IEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRG 380 + K+ EEID VIG R P ++DR MPY DAVVHEIQR+ LVP+ +PH T DT FR Sbjct: 301 VTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRN 360 Query: 381 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 440 YLIPKGT ++ L SVL+D++EFP+P F P HFL++NG FK SDYF PFS GKR+CAGE Sbjct: 361 YLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGE 420 Query: 441 GLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIP 491 GLARMELFL L ILQ+FNLK + D K+++ + + G +PP Y++C IP Sbjct: 421 GLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIP 471 >1N6B-A nrPDB Length = 473 Score = 561 bits (1445), Expect = e-160, Method: Compositional matrix adjust. Identities = 262/471 (55%), Positives = 347/471 (73%), Gaps = 4/471 (0%) Query: 22 MWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81 M ++ S LPPGP P PIIGN+ Q++ K+I KS T+ ++ +GPVFT+Y+G + VV+H Sbjct: 1 MAKKTSSKGKLPPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLH 60 Query: 82 GYKAVKEALLDYKDEFSGRGDLPAFH-AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGK 140 GY+AVKEAL+D +EF+GRG +P + GI F+N TWK++RRFSL TLRN+GMGK Sbjct: 61 GYEAVKEALVDLGEEFAGRGSVPILEKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGK 120 Query: 141 QGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLM 200 + E RIQ EA L+E LRKT P DPTF++GCAPCNVI ++F FDY DE+FL+LM Sbjct: 121 RSIEDRIQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKLM 180 Query: 201 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 260 +EN LL TPWLQ+YNNFP+ L Y PG H+ ++KN +K ++ E+VKEH + LD N Sbjct: 181 ESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDVN 240 Query: 261 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 320 PRD DC L++ME+E + +T++ + + V+DLF AGTETTSTTLRY LL+L+K+PE Sbjct: 241 NPRDFIDCFLIKMEQENNLE---FTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPE 297 Query: 321 IEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRG 380 + ++ EEI+RVIG R P ++DR MPY DAV+HEIQRFI L+P+NLPH TRD FR Sbjct: 298 VAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRN 357 Query: 381 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 440 Y IPKGT ++ +L SVL+D + FP+P+ F P HFL+E+G FK SDYF PFS GKR+C GE Sbjct: 358 YFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGE 417 Query: 441 GLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIP 491 GLARMELFL L +ILQ+F L+ LV+PKD+D++ + GF +PP Y+LC IP Sbjct: 418 GLARMELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPSYQLCFIP 468 >2PG7-A nrPDB Length = 476 Score = 471 bits (1213), Expect = e-133, Method: Compositional matrix adjust. Identities = 224/472 (47%), Positives = 316/472 (66%), Gaps = 1/472 (0%) Query: 22 MWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81 M ++ S LPPGP PLP IGN QL + + S ++++R+GPVFT+++G +R+VV+ Sbjct: 1 MAKKTSSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLC 60 Query: 82 GYKAVKEALLDYKDEFSGRGDLPAFH-AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGK 140 G+ AV+EAL+D +EFSGRG+ F + G++F+NG K +RRFS+ TLR++G+GK Sbjct: 61 GHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGK 120 Query: 141 QGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLM 200 +G E RIQ EA FL++ALR T G DPTF + NVI+ I+F FDY D++FL L+ Sbjct: 121 RGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLL 180 Query: 201 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 260 + F ST QLY F S + +LPG ++ + + ++++++++V+ + ++LDPN Sbjct: 181 RMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPN 240 Query: 261 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 320 PRD D L+ M++E+ + + + + +T LF GTET STTLRYG L+LMK+PE Sbjct: 241 SPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPE 300 Query: 321 IEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRG 380 +E K+HEEIDRVIG +R P +DR +MPYM+AV+HEIQRF ++P +L +DT FR Sbjct: 301 VEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRD 360 Query: 381 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 440 + +PKGT V P L SVL D F +P+ F P+HFLNE G+FK SD F PFS GKR C GE Sbjct: 361 FFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGE 420 Query: 441 GLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492 GLARMELFL ++Q+F LK PKDID+SP H+GF IP Y + +PR Sbjct: 421 GLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 472 >5E0E-A nrPDB Length = 463 Score = 464 bits (1194), Expect = e-131, Method: Compositional matrix adjust. Identities = 218/450 (48%), Positives = 311/450 (69%), Gaps = 1/450 (0%) Query: 44 NLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDL 103 NL Q++ SF R+ +++G VFT+++G + +V+++G +A++EAL+D + FSGRG + Sbjct: 14 NLLQMDRGGFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 73 Query: 104 PAFH-AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQ 162 R G++F NG WK +RRFSL T+R++GMGK+ E RIQ EA L+E RK+Q Sbjct: 74 AVVEPIFRGYGVVFANGERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEFRKSQ 133 Query: 163 GQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFP 222 G P DPTFL C N+I I+F + FDY D +FLRL+YLF ++F L+S+ Q++ F Sbjct: 134 GAPLDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFS 193 Query: 223 SFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAER 282 FL Y PG+HR++ +N+ E+ +Y+ + V++H +LDP+ PRD D L+ MEKEK + Sbjct: 194 GFLKYFPGTHRQISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSNQHT 253 Query: 283 LYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIK 342 + + ++V LFFAGTET+STTLRYG L+++KYP + EK+ +EID+VIG R+P ++ Sbjct: 254 EFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLE 313 Query: 343 DRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQE 402 DR +MPY +AV++EIQRF L+P +PH+ T+DT+FRGYL+PK T V P L S L+D Q Sbjct: 314 DRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 373 Query: 403 FPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKP 462 F P+ F P+HFL+ NG K S+ F PFS GKR+C GEG+AR ELFL ILQ+F+L Sbjct: 374 FEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSLSS 433 Query: 463 LVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492 V PKDIDLSP GFG +P Y++C + R Sbjct: 434 PVAPKDIDLSPKESGFGKVPQTYQICFLAR 463 >5E58-A nrPDB Length = 493 Score = 462 bits (1189), Expect = e-130, Method: Compositional matrix adjust. Identities = 217/450 (48%), Positives = 305/450 (67%), Gaps = 1/450 (0%) Query: 44 NLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDL 103 NL Q++ SF R+ +++G VFT+++G + +V+++G +A++EAL+D + FSGRG + Sbjct: 42 NLLQMDRGGFLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 101 Query: 104 PAFH-AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQ 162 D G+IF+NG WK +RRFSL T+R++GMGK+ E RIQ EA L+E L+K+Q Sbjct: 102 AVIKPVIGDYGMIFSNGERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVEELQKSQ 161 Query: 163 GQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFP 222 G P DPTFL C N+I I+F + +DY D +FLRL+ LF F L+S+ Q++ F Sbjct: 162 GAPLDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFS 221 Query: 223 SFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAER 282 F+ Y PG+HR++ +N+ E+ +YV + V++H +LDP+ PRD D L+ MEKEK + Sbjct: 222 GFMKYFPGAHRQITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSNQHT 281 Query: 283 LYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIK 342 + + ++V LFFAGTETTSTTLRYG L+++KYP + EK+ +EID+VIG R+P ++ Sbjct: 282 EFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLE 341 Query: 343 DRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQE 402 DR +MPY DAV+HEIQRF L P PH+ T+DT+FRGYL+PK T V P L S L+D Q Sbjct: 342 DRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 401 Query: 403 FPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKP 462 F P F P+HFL+ NG K S+ F PFS GKR+C GEG+AR ELFL ILQ+F++ Sbjct: 402 FEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSVSS 461 Query: 463 LVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492 V PKDIDLSP G G +P Y++ + R Sbjct: 462 SVAPKDIDLSPKESGIGKVPQTYQISFLAR 491 >4H1N-A nrPDB Length = 479 Score = 452 bits (1164), Expect = e-127, Method: Compositional matrix adjust. Identities = 224/475 (47%), Positives = 315/475 (66%), Gaps = 7/475 (1%) Query: 22 MWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81 M ++ S LPPGP PLP++GNL Q++ K + +SF RL +++G VFT+Y+GS+ +VV+ Sbjct: 1 MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLC 60 Query: 82 GYKAVKEALLDYKDEFSGRGDL----PAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYG 137 G A++EAL+D + FSGRG + P F + G+IF NG W+ +RRFSL T+R++G Sbjct: 61 GTDAIREALVDQAEAFSGRGKIAVVDPIFQGY---GVIFANGERWRALRRFSLATMRDFG 117 Query: 138 MGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFL 197 MGK+ E RIQ EA L+E LRK++G D T L N+I I+F K FDY D FL Sbjct: 118 MGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFL 177 Query: 198 RLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSL 257 RL+ LF ++F L+S+ Q++ F FL Y PG+HR++ +N+ E+ ++ + V++H +L Sbjct: 178 RLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATL 237 Query: 258 DPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMK 317 DP+ PRD D L+ MEK+K + + +TV LF AGTETTSTTLRYG L+++K Sbjct: 238 DPSNPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLK 297 Query: 318 YPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTI 377 YP + E++ +EI++VIG R PA+ DR +MPY DAV+HEIQR L+P +PH T+DT Sbjct: 298 YPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQ 357 Query: 378 FRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVC 437 FRGY+IPK T V P L S L+D + F P F P HFL+ NG K ++ F PFS GKR+C Sbjct: 358 FRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRIC 417 Query: 438 AGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492 GEG+AR ELFL ILQ+F++ V P+DIDL+P G G +PP Y++ + R Sbjct: 418 LGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNVPPSYQIRFLAR 472 >3IBD-A nrPDB Length = 476 Score = 444 bits (1142), Expect = e-125, Method: Compositional matrix adjust. Identities = 213/453 (47%), Positives = 307/453 (67%), Gaps = 7/453 (1%) Query: 44 NLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDL 103 NL Q++ + + KSF R +++G VFT+++G + +V++ G +A++EAL+D + FSGRG + Sbjct: 23 NLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKI 82 Query: 104 ----PAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALR 159 P F R G+IF NG WK +RRFS+TT+R++GMGK+ E RIQ EA L+E LR Sbjct: 83 AMVDPFF---RGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELR 139 Query: 160 KTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYN 219 K++G DPTFL N+I I+F K F Y D++FL+++ LF + F L+S+ + QL+ Sbjct: 140 KSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFE 199 Query: 220 NFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHS 279 F FL + PG+HR+V KN+ E+ Y+ V++H ++LDP+ PRDL D L+ MEKEK + Sbjct: 200 LFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSN 259 Query: 280 AERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIP 339 A ++ + + LFFAGTETTSTTLRYG L+++KYP + E+++ EI++VIGP R P Sbjct: 260 AHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPP 319 Query: 340 AIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYD 399 + DR +MPY +AV++EIQRF L+P +PH T+ T FRGY+IPK T V L + L+D Sbjct: 320 ELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHD 379 Query: 400 NQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFN 459 F P+ F P+HFL+ NG K ++ F PFS GKR+C GEG+AR ELFL ILQ+F+ Sbjct: 380 PHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS 439 Query: 460 LKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492 + V P+DIDL+P G G IPP Y++ +PR Sbjct: 440 MASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 472 >3TBG-A nrPDB Length = 479 Score = 318 bits (815), Expect = 4e-87, Method: Compositional matrix adjust. Identities = 179/456 (39%), Positives = 260/456 (57%), Gaps = 16/456 (3%) Query: 47 QLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAF 106 ++ +N P F +L +RFG VF+L + +VV++G AV+EAL+ + ++ + R +P Sbjct: 26 HVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPIT 85 Query: 107 H----AHRDRGIIFNN-GPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKT 161 R +G+ GP W++ RRFS++TLRN G+GK+ E + EA L A Sbjct: 86 QILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANH 145 Query: 162 QGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNF 221 G+PF P L+ A NVIA + + F+Y+D +FLRL+ L E S ++ N Sbjct: 146 SGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAV 205 Query: 222 PSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDP-NCPRDLTDCLLVEMEKEKHSA 280 P LH +P KV++ + E + EH + DP PRDLT+ L EMEK K + Sbjct: 206 PVLLH-IPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNP 264 Query: 281 ERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPA 340 E + + + + VADLF AG TTSTTL +GLL+++ +P+++ ++ +EID VIG R P Sbjct: 265 ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPE 324 Query: 341 IKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDN 400 + D+ MPY AV+HE+QRF +VP + H +RD +G+ IPKGT ++ L SVL D Sbjct: 325 MGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDE 384 Query: 401 QEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNL 460 + P +F PEHFL+ G F + F PFS G+R C GE LARMELFL ++LQHF+ Sbjct: 385 AVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF 444 Query: 461 K-PLVDPKDIDLSPIHIG---FGCIPPRYKLCVIPR 492 P P+ P H G F P Y+LC +PR Sbjct: 445 SVPTGQPR-----PSHHGVFAFLVSPSPYELCAVPR 475 >3DL9-A nrPDB Length = 479 Score = 288 bits (738), Expect = 3e-78, Method: Compositional matrix adjust. Identities = 163/456 (35%), Positives = 259/456 (56%), Gaps = 12/456 (2%) Query: 44 NLFQLELKN-IPKSFTR-LAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRG 101 N++ L + +P + R +Q +G +F+L +G VV++GY VKE L+ + F+ R Sbjct: 25 NIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRP 84 Query: 102 DLPAFHAHRDRGIIFNN--GPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALR 159 LP F G + N+ G W D RR ++ + R +G G++ ES+I E F +A+ Sbjct: 85 CLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIE 144 Query: 160 KTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYN 219 +G+PFD LI A N+ I+F + F Y D F ++ LF+EN L ++ + LYN Sbjct: 145 TYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYN 204 Query: 220 NFPSFLHYLP-GSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKH 278 FP ++ LP G H+++ +N A V +++S +++ + P P+ D L EM++ K+ Sbjct: 205 AFP-WIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKN 263 Query: 279 SAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRI 338 ++ + + +V +L AGTETT+ LR+ +L + YP I+ ++ +EID ++GP+ Sbjct: 264 DPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGK 323 Query: 339 PAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLY 398 P+ D+ +MPY +AV+HE+ RF +VP + H + D + RGY IPKGT V+ L SV + Sbjct: 324 PSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHF 383 Query: 399 DNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 D + + DPE F PE FL+ +G F + PFS G+R C GE LARME+FL A+LQ F Sbjct: 384 DEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 443 Query: 459 NLKPLVDPKDI--DLSPIHIGFGCIPPRYKLCVIPR 492 +L P ++ DL P +G P Y +C R Sbjct: 444 HLH---FPHELVPDLKP-RLGMTLQPQPYLICAERR 475 >4R20-A nrPDB Length = 486 Score = 237 bits (604), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 145/442 (32%), Positives = 236/442 (53%), Gaps = 13/442 (2%) Query: 57 FTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPA--FHAHRDRGI 114 FT+L+ ++GP+F LY G +V+ V+E LL EF+GR + + I Sbjct: 45 FTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQGGKDI 104 Query: 115 IFNN-GPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIG 173 F + P WK+ RR ++ +G G ++ +Q A L E L+ +GQ D + ++ Sbjct: 105 AFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSDLSVVLM 164 Query: 174 CAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHR 233 A NVI ++F + +D + L+ + +N+ + + L + FP +L P Sbjct: 165 RAVTNVICRLVFSSSYQPSDPE-LQTVIQYNDGI-VQTIARGGLVDIFP-WLRIFPNKDL 221 Query: 234 KVIKNVAEVK-EYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVT 292 K +K ++ + + +++ EH +SL P PRDL D LL+ ++ A+ + T D + +T Sbjct: 222 KRLKECVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALLIGQQRGSGGADDI-TEDHVLMT 280 Query: 293 VADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDA 352 A+ F AG ETTSTTL + + L+ +P+++E++ E+D +G R P + DR +P +DA Sbjct: 281 AAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPHLPLLDA 340 Query: 353 VVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPE 412 V+ E+ R + P +PH A +DT G+ +PKGT V+ + ++ +D + + PE+F PE Sbjct: 341 VLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQPEQFNPE 400 Query: 413 HFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLS 472 FL +GK K F PF G RVC GE LAR+ELFL + LQ F+ P + L Sbjct: 401 RFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFS---CPSEASLP 457 Query: 473 PIHIGFGCI--PPRYKLCVIPR 492 + FG + P RY + V PR Sbjct: 458 DLQGRFGVVLQPERYTVTVTPR 479 >6DWN-A nrPDB Length = 491 Score = 219 bits (559), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 144/462 (31%), Positives = 242/462 (52%), Gaps = 26/462 (5%) Query: 33 PPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD 92 PPGP+ P+IG++ L KN + +R++Q++G V + +GS +VV+ G +++AL+ Sbjct: 13 PPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVR 71 Query: 93 YKDEFSGRGDLPAFH-AHRDRGIIF--NNGPTWKDIRRFSLTTLRNYGMGKQGN------ 143 D+F GR DL F + + F ++GP W RR + L+++ + Sbjct: 72 QGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCY 131 Query: 144 -ESRIQREAHFLLEALRKTQGQP--FDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLM 200 E + +EA L+ L++ P F+P + + NVI I F + +D+N ++ L L+ Sbjct: 132 LEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLV 191 Query: 201 YLFNENFHLLST--PWLQLYNNFPSFLHYLPGSHRKVIKNVAE-VKEYVSERVKEHHQSL 257 L N ++ + P +F L YLP K++ E ++ + VKEH+++ Sbjct: 192 NLNNNFGEVVGSGNP-----ADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTF 246 Query: 258 DPNCPRDLTDCLLVEMEKEK--HSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLIL 315 + RD+TD L+ ++++ +A + + I V DLF AG +T +T + + L+ L Sbjct: 247 EKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYL 306 Query: 316 MKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRD 375 + P ++ K+ EE+D VIG SR P + DR +PYM+A + E R + VP +PH TRD Sbjct: 307 VMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRD 366 Query: 376 TIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFK--YSDYFKPFSTG 433 T +G+ IPKG V + +D + + +P +F PE FL +G S+ F G Sbjct: 367 TSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMG 426 Query: 434 KRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIH 475 KR C GE +AR E+FL L +LQ + K +D++PI+ Sbjct: 427 KRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTPIY 467 >2HI4-A nrPDB Length = 495 Score = 215 bits (547), Expect = 4e-56, Method: Compositional matrix adjust. Identities = 143/461 (31%), Positives = 234/461 (50%), Gaps = 25/461 (5%) Query: 33 PPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD 92 PP P+ P++G++ L KN + +R++QR+G V + +GS ++V+ +++AL+ Sbjct: 18 PPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVR 76 Query: 93 YKDEFSGRGDLPAFHAHRD-RGIIF--NNGPTWKDIRRFSLTTLRNYGMGKQGN------ 143 D+F GR DL D + + F ++GP W RR + L + + Sbjct: 77 QGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCY 136 Query: 144 -ESRIQREAHFLLEALRKTQGQP--FDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLM 200 E + +EA L+ L++ P FDP + + NVI + F +HF + ++ L L+ Sbjct: 137 LEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLV 196 Query: 201 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAE-VKEYVSERVKEHHQSLDP 259 +E S+ + FP L YLP + K + ++ + V+EH+Q D Sbjct: 197 KNTHEFVETASSG--NPLDFFP-ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDK 253 Query: 260 NCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYP 319 N RD+T L +K ++ L + I V D+F AG +T +T + + L+ L+ P Sbjct: 254 NSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKP 313 Query: 320 EIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFR 379 EI+ K+ +E+D VIG R P + DR ++PY++A + E R + +P +PH TRDT Sbjct: 314 EIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLN 373 Query: 380 GYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKF---KYSDYFKPFSTGKRV 436 G+ IPK V V +D + + DP +F+PE FL +G S+ F GKR Sbjct: 374 GFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRR 433 Query: 437 CAGEGLARMELFLLLCAILQH--FNLKPLVDPKDIDLSPIH 475 C GE LA+ E+FL L +LQ F++ P V +DL+PI+ Sbjct: 434 CIGEVLAKWEIFLFLAILLQQLEFSVPPGV---KVDLTPIY 471 >6B82-A nrPDB Length = 509 Score = 207 bits (526), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 144/474 (30%), Positives = 237/474 (50%), Gaps = 19/474 (4%) Query: 33 PPGPFPLPIIGNLFQLELKNIPKSFTR-LAQRFGPVFTLYVGSQRMVVMHGYKAVKEALL 91 PP LPIIG+L L + P F + L +++G +++L +GS ++++++ + KE L+ Sbjct: 25 PPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHHHAKEILI 84 Query: 92 DYKDEFSGR-GDLPAFHAHRD-RGIIFNN-GPTWKDIRRFSLTTLRNYGMGKQGNESRIQ 148 F+GR + RD + I F + TWK R+ L +G G E I Sbjct: 85 KKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGEGSVSIEKIIC 144 Query: 149 REAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFH 208 REA + E L ++Q D + A NV+ + F + D +F ++ Sbjct: 145 REASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSSYKRGDAEFESMLQYSQGIVD 204 Query: 209 LLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKE-YVSERVKEHHQSLDPNCPRDLTD 267 ++ L + FP +L P ++++ +++ + ++ +EH + N RDL D Sbjct: 205 TVAKD--SLVDIFP-WLQIFPNKDLRILRQCISIRDKLLQKKYEEHKVTYSDNVQRDLLD 261 Query: 268 CLLVEMEKEKHSAERL----YTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEE 323 LL +++ T D + +TV ++F AG ETT+TTL++ + L+ P+++ Sbjct: 262 ALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTTLKWSIAYLVHNPQVQR 321 Query: 324 KLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLI 383 K+ EE+D IG R P + DR +PY++A + E+ R + P +PH A +D+ Y + Sbjct: 322 KIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIPHVALQDSSVGEYTV 381 Query: 384 PKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKY--SDYFKPFSTGKRVCAGEG 441 KGT VV + S+ +D +E+ +PE F P FLNE G S + PF G RVC GE Sbjct: 382 QKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEA 441 Query: 442 LARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCI--PPRYKLCVIPRS 493 LA+MELFL L ILQ F L+ P L + FG + P ++K+ R+ Sbjct: 442 LAKMELFLFLAWILQRFTLEM---PTGQPLPDLQGKFGVVLQPKKFKVVAKVRA 492 >6IQ5-A nrPDB Length = 463 Score = 200 bits (509), Expect = 9e-52, Method: Compositional matrix adjust. Identities = 144/470 (30%), Positives = 235/470 (50%), Gaps = 52/470 (11%) Query: 56 SFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHR----D 111 SF RLA+R+G VF + +GS +VV++G +A+ +AL+ F+ R P+F + R Sbjct: 6 SFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADR---PSFASFRVVSGG 62 Query: 112 RGIIFNN-GPTWKDIRRFSLTTLRNYGM----GKQGNESRIQREAHFLLEALRK--TQGQ 164 R + F + WK RR + + +RN+ +Q E + EA L+ L + G Sbjct: 63 RSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGA 122 Query: 165 PFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFH--------LLSTPWLQ 216 DP L A NV++ + F + ++D +F L+ NE F + PWLQ Sbjct: 123 FLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLS-HNEEFGRTVGAGSLVDVMPWLQ 181 Query: 217 LYNNFPSFLHYLPGSHRKVIKNVAEV----KEYVSERVKEHHQSLDPNC-PRDLTDCLLV 271 Y P R V + ++ ++ ++ H +SL P PRD+ D ++ Sbjct: 182 ----------YFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFIL 231 Query: 272 EMEK----EKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHE 327 EK + H ++ + T+ D+F A +T ST L++ LL+ +YP+++ ++ Sbjct: 232 SAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQA 291 Query: 328 EIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGT 387 E+D+V+G R+P + D+ +PY+ A ++E RF + VP +PH T +T GY IPK T Sbjct: 292 ELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDT 351 Query: 388 VVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFK--YSDYFKPFSTGKRVCAGEGLARM 445 VV SV +D ++P+PE F P FL+++G + FS GKR C GE L++M Sbjct: 352 VVFVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKM 411 Query: 446 ELFLLLCAILQH---FNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492 +LFL + +IL H F P +P ++ S G P +K+ V R Sbjct: 412 QLFLFI-SILAHQCDFRANP-NEPAKMNFS---YGLTIKPKSFKVNVTLR 456 >5UYS-A nrPDB Length = 494 Score = 192 bits (488), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 134/449 (29%), Positives = 236/449 (52%), Gaps = 30/449 (6%) Query: 33 PPGPFPLPIIGNL-FQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALL 91 P LP++G+L F ++ +F +L +++GP++++ +G++ V++ ++ KE L+ Sbjct: 10 PKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLI 69 Query: 92 DYKDEFSGRGDLPAFH--AHRDRGIIF-NNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQ 148 +FSGR + ++ +GI F ++G W+ RR ++ T + G Q E I Sbjct: 70 KKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIIC 129 Query: 149 REAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENF- 207 +E L + L GQ D +F + A NVI+ I F + D + L ++ +NE Sbjct: 130 QEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE-LNVIQNYNEGII 188 Query: 208 ------HLLS-TPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 260 L+ PWL++ FP+ SH K I+N ++ + E KE +S + Sbjct: 189 DNLSKDSLVDLVPWLKI---FPNKTLEKLKSHVK-IRN--DLLNKILENYKEKFRS---D 239 Query: 261 CPRDLTDCLL-VEMEKEKHSA-----ERLYTMDGITVTVADLFFAGTETTSTTLRYGLLI 314 ++ D L+ +M + +A L + + I T+ D+F AG ETT++ +++ L Sbjct: 240 SITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAF 299 Query: 315 LMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATR 374 L+ P++++KL+EEID+ +G SR P I DR + ++A + E+ R + P +PH+A Sbjct: 300 LLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANV 359 Query: 375 DTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK--FKYSDYFKPFST 432 D+ + + KGT V+ L ++ ++ +E+ P++F PE FLN G S + PF Sbjct: 360 DSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGA 419 Query: 433 GKRVCAGEGLARMELFLLLCAILQHFNLK 461 G R C GE LAR ELFL++ +LQ F+L+ Sbjct: 420 GPRSCIGEILARQELFLIMAWLLQRFDLE 448 >3QZ1-A nrPDB Length = 496 Score = 192 bits (487), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 127/437 (29%), Positives = 218/437 (49%), Gaps = 30/437 (6%) Query: 40 PIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSG 99 P++ L N+P L Q+ GPV+ L +G Q +VV++ + ++EA++ +F+G Sbjct: 32 PLVPGFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAG 91 Query: 100 RGDLPAFHAHRDRGIIFNNGP---TWKDIRRFSLTTLRNYGMGKQGN-ESRIQREAHFLL 155 R +P++ R + G WK ++ + + L +G + + E + + Sbjct: 92 RPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSALL---LGTRSSMEPWVDQLTQEFC 148 Query: 156 EALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPW- 214 E +R G P C++I + F D L++ F++ L W Sbjct: 149 ERMRVQAGAPVTIQKEFSLLTCSIICYLTFGNKEDT-------LVHAFHDCVQDLMKTWD 201 Query: 215 ---LQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSER-VKEHHQSLDPNCPRDLTDCLL 270 +Q+ + P FL + P +K E ++++ E+ ++ H +S+ RD+TD +L Sbjct: 202 HWSIQILDMVP-FLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDYML 260 Query: 271 VEMEKEKHSAERLYTMDG-ITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEI 329 + +++ ++G + ++V DLF GTETT++TL + + L+ +PEI+ +L EE+ Sbjct: 261 QGVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEEL 320 Query: 330 DRVIGP----SRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPK 385 DR +GP SR+ KDR +P ++A + E+ R +VP LPH TR + GY IP+ Sbjct: 321 DRELGPGASCSRV-TYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPE 379 Query: 386 GTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARM 445 G VV+P L D + P +F+P+ FL + F G RVC GE LAR+ Sbjct: 380 GMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGA----NPSALAFGCGARVCLGESLARL 435 Query: 446 ELFLLLCAILQHFNLKP 462 ELF++L +LQ F L P Sbjct: 436 ELFVVLARLLQAFTLLP 452 >4R1Z-A nrPDB Length = 439 Score = 187 bits (474), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 131/434 (30%), Positives = 212/434 (48%), Gaps = 18/434 (4%) Query: 72 VGSQRMVVMHGYKAVKEALLDYKDEFSGR-GDLPAFHAHRD-RGIIFNN-GPTWKDIRRF 128 +GS ++++++ + KE L+ F+GR + RD + I F + TWK R+ Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKM 60 Query: 129 SLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKH 188 L +G G E I REA + E L ++Q D + A NV+ + F Sbjct: 61 VHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSS 120 Query: 189 FDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKE-YVS 247 + D +F ++ ++ L + FP +L P +++ +++ + Sbjct: 121 YKRGDAEFESMLQYSQGIVDTVAKD--SLVDIFP-WLQIFPNKDLTILRQCISIRDKLLQ 177 Query: 248 ERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERL----YTMDGITVTVADLFFAGTET 303 ++ +EH + N RDL D LL +++ T D + +TV D+F AG ET Sbjct: 178 KKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFGAGVET 237 Query: 304 TSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITL 363 T+T L++ + L+ P+++ K+ EE+D IG R P + DR +PY++A + E+ R + Sbjct: 238 TTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPV 297 Query: 364 VPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKY 423 P +PH A +D+ Y + KGT VV L S+ +D +E+ +PE F P FLNE G Sbjct: 298 SPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEGDGLC 357 Query: 424 --SDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCI 481 S + PF G RVC GE LA+MELFL L ILQ F L+ P L + FG + Sbjct: 358 CPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEM---PTGQPLPDLQGKFGVV 414 Query: 482 --PPRYKLCVIPRS 493 P ++K+ R+ Sbjct: 415 LQPKKFKVVAKVRA 428 >5VBU-A nrPDB Length = 476 Score = 180 bits (456), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 130/460 (28%), Positives = 222/460 (48%), Gaps = 38/460 (8%) Query: 22 MWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81 M ++ S LPP + L ++P L Q+FGP++ L++G Q +VV++ Sbjct: 1 MAKKTSSKGKLPP------LAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLN 54 Query: 82 GYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPT---------WKDIRRFSLTT 132 + ++EA++ +F+GR + + ++ N P WK ++ + + Sbjct: 55 SKRTIEEAMVKKWADFAGRPEPLTYK------LVSRNYPDLSLGDYSLLWKAHKKLTRSA 108 Query: 133 LRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYN 192 L G+ + E +++ E +R G P C++I + F Sbjct: 109 LL-LGI-RDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKI--K 164 Query: 193 DEKFLRLMY-LFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSE-RV 250 D+ + Y E S +Q+ + P FL + P + +K E ++++ E ++ Sbjct: 165 DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQAIEKRDHIVEMQL 223 Query: 251 KEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDG-ITVTVADLFFAGTETTSTTLR 309 ++H +SL RD+ D +L + + ++G + + DL GTETT+ TL Sbjct: 224 RQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLS 283 Query: 310 YGLLILMKYPEIEEKLHEEIDRVIGP----SRIPAIKDRQEMPYMDAVVHEIQRFITLVP 365 + ++ L+ +PEI+++L EE+D +GP SR+P KDR +P ++A + E+ R +VP Sbjct: 284 WAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNATIAEVLRLRPVVP 342 Query: 366 SNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSD 425 LPH TR + GY IP+GTV++P L D + P +F P+ FL E GK + Sbjct: 343 LALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFL-EPGK---NS 398 Query: 426 YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVD 465 F G RVC GE LAR+ELF++L +LQ F L P D Sbjct: 399 RALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGD 438 >5YLW-A nrPDB Length = 495 Score = 164 bits (414), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 136/480 (28%), Positives = 227/480 (47%), Gaps = 38/480 (7%) Query: 1 MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60 M + + AL AA + +S R+ NLPPGPFP PI+GN+ QL N + F +L Sbjct: 1 MDSFPLLAALFFIAATITFLSFRRR----RNLPPGPFPYPIVGNMLQLG-ANPHQVFAKL 55 Query: 61 AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP 120 ++R+GP+ ++++GS V++ + KE L + FSGR A HA I P Sbjct: 56 SKRYGPLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDKISMGFLP 115 Query: 121 T---WKDIRRFSLTTL-RNYGMGKQGNESRIQREAHFLLEALRKTQ--GQPFDPTFLIGC 174 W+D+R+ + N M + ++ +++ LL+ ++K G+ D Sbjct: 116 VASEWRDMRKICKEQMFSNQSM--EASQGLRRQKLQQLLDHVQKCSDSGRAVDIREAAFI 173 Query: 175 APCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLP----- 229 N+++ LF D K F E ++T P+F Y P Sbjct: 174 TTLNLMSATLFSSQATEFDSK---ATMEFKEIIEGVAT-----IVGVPNFADYFPILRPF 225 Query: 230 ---GSHRKVI----KNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAER 282 G R+ K +A+++ Y++ER++ + +PN P+ D L + ++ + + + Sbjct: 226 DPQGVKRRADVFFGKLLAKIEGYLNERLES--KRANPNAPKK-DDFLEIVVDIIQANEFK 282 Query: 283 LYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIK 342 L T T + DLF G++T +T++ + + L+ P+ +L E+ V G +I Sbjct: 283 LKTHH-FTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDES 341 Query: 343 DRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQE 402 ++PY+ AV+ E+ R P LP +A D GYLIPKGT ++ ++ D Sbjct: 342 AMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSI 401 Query: 403 FPDPEKFKPEHFLNENGKFKYSDY-FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 461 + DPE F PE FL+ FK DY PF +G+RVC G LA L + ++ +F+ K Sbjct: 402 WTDPETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNFDWK 461 >6DA2-A nrPDB Length = 487 Score = 110 bits (274), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 116/448 (25%), Positives = 190/448 (42%), Gaps = 38/448 (8%) Query: 34 PGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDY 93 PGP PLP +GN+ K +++G V+ Y G Q ++ + +K L+ Sbjct: 19 PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLV-- 75 Query: 94 KDEFSGRGDLPAFH--AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREA 151 K+ +S + F I WK +R T + + + I + Sbjct: 76 KECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEM--VPIIAQYG 133 Query: 152 HFLLEALRKTQ--GQPFDPTFLIGCAPCNVIADILFRKHFDY----------NDEKFLRL 199 L+ LR+ G+P + G +VI F + D N +K LR Sbjct: 134 DVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRF 193 Query: 200 MYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDP 259 +L P+ FP + L + V EV ++ + VK +S Sbjct: 194 DFL---------DPFFLSITVFPFLIPILEVLNICVFPR--EVTNFLRKSVKRMKESRLE 242 Query: 260 NCPRDLTDCLLVEME----KEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLIL 315 + + D L + ++ KE S + L ++ + ++ FAG ETTS+ L + + L Sbjct: 243 DTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSII-FIFAGYETTSSVLSFIMYEL 301 Query: 316 MKYPEIEEKLHEEIDRVIGPSRIPAIKDRQ-EMPYMDAVVHEIQRFITLVPSNLPHEATR 374 +P++++KL EEID V+ P++ P D +M Y+D VV+E R + L + Sbjct: 302 ATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKK 359 Query: 375 DTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGK 434 D G IPKG VV+ ++ D + + +PEKF PE F +N + PF +G Sbjct: 360 DVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGP 419 Query: 435 RVCAGEGLARMELFLLLCAILQHFNLKP 462 R C G A M + L L +LQ+F+ KP Sbjct: 420 RNCIGMRFALMNMKLALIRVLQNFSFKP 447 >3K9V-A nrPDB Length = 482 Score = 105 bits (262), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 107/472 (22%), Positives = 209/472 (44%), Gaps = 46/472 (9%) Query: 34 PGPFPLPIIGNLFQL----ELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEA 89 PGP P++G+L ++ LK + +++G +F + +GS V + G ++ EA Sbjct: 27 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEA 85 Query: 90 LLDYKDEFSGRGDLPAFHAHRDR-----GIIFNNGPTWKDIRR-FSLTTLRNYGMGKQGN 143 L + R ++ + A+RD G++ G W+ +R F ++ + K Sbjct: 86 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKL-- 143 Query: 144 ESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL-MYL 202 + +I LE + + C I D+ + + N F + + L Sbjct: 144 DKKINEVLADFLERMDEL------------CDERGRIPDL----YSELNKWSFESICLVL 187 Query: 203 FNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCP 262 + + F LL + F + + + + K++ E+ + ++ +V + H Sbjct: 188 YEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIF 247 Query: 263 RDLTDCLLVEMEK--EKHSAERL---YTMDGIT-----VTVADLFFAGTETTSTTLRYGL 312 + + C+ +++ ++ A+ L Y D ++ V +L A ETT+ +L + L Sbjct: 248 KSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWIL 307 Query: 313 LILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEA 372 L + P+ + +L +E+ V+ ++ P +D + MPY+ A + E R VP Sbjct: 308 YNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTL 366 Query: 373 TRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFST 432 + T+ Y +PKGTV+ + F D KF+PE +L + K + PF Sbjct: 367 DKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHL-PFGI 425 Query: 433 GKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR 484 GKR+C G LA ++L L LC I+Q +++ D + +++ +H+G +P R Sbjct: 426 GKRMCIGRRLAELQLHLALCWIIQKYDIVA-TDNEPVEM--LHLGI-LVPSR 473 >5VEU-A nrPDB Length = 480 Score = 104 bits (259), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 110/443 (24%), Positives = 193/443 (43%), Gaps = 29/443 (6%) Query: 34 PGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALL-D 92 PGP PLP++GN+ + + K T +++G ++ Y G ++ + ++ L+ + Sbjct: 18 PGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 76 Query: 93 YKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAH 152 F+ R L + I WK IR T + + + I + Sbjct: 77 CYSVFTNRRSLGPVGFMKS-AISLAEDEEWKRIRSLLSPTFTSGKLKEMF--PIIAQYGD 133 Query: 153 FLLEALRKT--QGQPFDPTFLIGCAPCNVIADILFRKHFDY----------NDEKFLRLM 200 L+ LR+ +G+P + G +VI F + D + +KFL+ Sbjct: 134 VLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFG 193 Query: 201 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 260 +L ++ P+L + + + + K+V +K+ ++H Sbjct: 194 FLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDF--- 250 Query: 261 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 320 L + + KE S + L ++ ++ FAG ETTS+ L + L L +P+ Sbjct: 251 ----LQLMIDSQNSKETESHKALSDLELAAQSII-FIFAGYETTSSVLSFTLYELATHPD 305 Query: 321 IEEKLHEEIDRVIGPSRIPAIKDR-QEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFR 379 +++KL +EID V+ P++ P D +M Y+D VV+E R V L +D Sbjct: 306 VQQKLQKEIDAVL-PNKAPPTYDAVVQMEYLDMVVNETLRLFP-VAIRLERTCKKDVEIN 363 Query: 380 GYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAG 439 G IPKG++VV ++ +D + + +PE+F+PE F + Y PF TG R C G Sbjct: 364 GVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY-TPFGTGPRNCIG 422 Query: 440 EGLARMELFLLLCAILQHFNLKP 462 A M + L L +LQ+F+ KP Sbjct: 423 MRFALMNMKLALIRVLQNFSFKP 445 >3S79-A nrPDB Length = 503 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 92/378 (24%), Positives = 170/378 (44%), Gaps = 33/378 (8%) Query: 93 YKDEFSGRGDLPAFHAHRDRGIIFNNGPT-WKDIRRFSLTTLRNYGMGKQGNESRIQREA 151 Y F + L H ++GIIFNN P WK R F + L G+ + + Sbjct: 112 YSSRFGSKLGLQCIGMH-EKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKT 170 Query: 152 HF-LLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLL 210 H LE + G +V+ +L R D ++ FLR+ +E+ ++ Sbjct: 171 HLDRLEEVTNESGY------------VDVLT-LLRRVMLDTSNTLFLRIP--LDESAIVV 215 Query: 211 ST-----PWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDL 265 W L P + ++K K+V ++K+ + + E + + + L Sbjct: 216 KIQGYFDAWQALLIK-PDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRI--STEEKL 272 Query: 266 TDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKL 325 +C+ E T + + + ++ A +T S +L + L ++ K+P +EE + Sbjct: 273 EECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAI 332 Query: 326 HEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPK 385 +EI VIG I I D Q++ M+ ++E R+ +V + +A D + GY + K Sbjct: 333 IKEIQTVIGERDI-KIDDIQKLKVMENFIYESMRYQPVVDLVM-RKALEDDVIDGYPVKK 390 Query: 386 GTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARM 445 GT ++ + ++ + FP P +F E+F +N ++ YF+PF G R CAG+ +A + Sbjct: 391 GTNIILNIGR-MHRLEFFPKPNEFTLENF-AKNVPYR---YFQPFGFGPRGCAGKYIAMV 445 Query: 446 ELFLLLCAILQHFNLKPL 463 + +L +L+ F++K L Sbjct: 446 MMKAILVTLLRRFHVKTL 463 >6C94-A nrPDB Length = 497 Score = 89.7 bits (221), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 98/457 (21%), Positives = 182/457 (39%), Gaps = 43/457 (9%) Query: 34 PGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDY 93 PGP + G+ +++ Q+F L+VG G+ + E DY Sbjct: 25 PGPPTHWLFGHALEIQKTGSLDKVVTWTQQFPYAHPLWVGQ-----FIGFLNIYEP--DY 77 Query: 94 KDEFSGRGDLPA------FHAHRDRGIIFNNGPTWKDIRR-----FSLTTLRNYGMGKQG 142 RGD A F +G++ +GP W R+ F L+ Y + Sbjct: 78 AKAVYSRGDPKAPDVYDFFLQWIGKGLLVLDGPKWFQHRKLLTPGFHYDVLKPY-VAIFA 136 Query: 143 NESRIQREAHFLLEALRK--TQGQPFDPTFLIGCAPCNVIADILFRKH---FDYNDEKFL 197 + +RI +LE K +G+ FD +G + + F K ++ D + Sbjct: 137 DSTRI------MLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSY- 189 Query: 198 RLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSL 257 Y+ LL + + F+++L R+ ++ ++ +++ +L Sbjct: 190 ---YVAVSELTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACRAAHDHTDRVIRQRKAAL 246 Query: 258 DPNCPRDLT------DCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYG 311 R+ D L + ++ S +L D + V F G +TT++ + + Sbjct: 247 QDEKEREKIQNRRHLDFLDILLDVRGESGVQLSDTD-LRAEVDTFMFEGHDTTTSGISWF 305 Query: 312 LLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHE 371 L + YPE +++ EE+ ++G +D +M Y+ + E R VP Sbjct: 306 LYCMALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQL 365 Query: 372 ATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFS 431 + + G +P G+++ + ++ ++ +PDPE F P F EN ++ F PFS Sbjct: 366 SKPVSFVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFS 425 Query: 432 TGKRVCAGEGLA--RMELFLLLCAILQHFNLKPLVDP 466 G R C G+ A M++ LC + F++ PL P Sbjct: 426 AGPRNCIGQQFAMNEMKVVTALCLLRFEFSVDPLRLP 462 >2VE3-A nrPDB Length = 444 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 65/231 (28%), Positives = 108/231 (46%), Gaps = 15/231 (6%) Query: 231 SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGIT 290 S R +AE+++ + R ++ P D LL + D I Sbjct: 196 SQRARALLLAELEKIIKARQQQ------PPSEEDALGILLAARDDNNQPLSLPELKDQIL 249 Query: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350 + L FAG ET ++ L L+L ++ +I E++ +E +++ + A + ++MPY+ Sbjct: 250 L----LLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQNKLQLSQELTA-ETLKKMPYL 304 Query: 351 DAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410 D V+ E+ R I V E +D F+G+ PKG +V + D +PDPEKF Sbjct: 305 DQVLQEVLRLIPPVGGGF-RELIQDCQFQGFHFPKGWLVSYQISQTHADPDLYPDPEKFD 363 Query: 411 PEHFLNENGKFKYSDYFK--PFSTGKRVCAGEGLARMELFLLLCAILQHFN 459 PE F +G ++ F PF G R C G+ AR+E+ L ++Q F+ Sbjct: 364 PERF-TPDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKLFATRLIQQFD 413 >3EL3-A nrPDB Length = 467 Score = 79.0 bits (193), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 92/365 (25%), Positives = 153/365 (41%), Gaps = 35/365 (9%) Query: 113 GIIFNNGPTWKDIRR-----FSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFD 167 G+ NGP + RR F L + YG ++ EAH L E R G+ D Sbjct: 103 GVATANGPLHRRQRRTIQPAFRLDAIPAYG-------PIMEEEAHALTE--RWQPGKTVD 153 Query: 168 PTFLIGCAPCNVIADILFRKHFDYNDEKFLRL----MYLFNENFHLLSTPWLQLYNNFPS 223 T V A L R Y DE+ RL +F + + P LY P Sbjct: 154 ATSESFRVAVRVAARCLLRGQ--YMDERAERLCVALATVFRGMYRRMVVPLGPLYR-LP- 209 Query: 224 FLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERL 283 LP ++R+ +A++ V E + E S P DL LL E + + + + Sbjct: 210 ----LP-ANRRFNDALADLHLLVDEIIAERRAS--GQKPDDLLTALL---EAKDDNGDPI 259 Query: 284 YTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKD 343 + I V + G+ET ++T+ + L L +PE +++ +E++ V G R A +D Sbjct: 260 GEQE-IHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTG-GRPVAFED 317 Query: 344 RQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF 403 +++ + V+ E R V L A ++ GY IP G ++ + ++ D + + Sbjct: 318 VRKLRHTGNVIVEAMRLRPAV-WVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSY 376 Query: 404 PDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL 463 D +F P+ +L E KPFS GKR C + + +L L+ A+ + + + Sbjct: 377 DDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQV 436 Query: 464 VDPKD 468 D Sbjct: 437 AGSND 441 >4KPA-A nrPDB Length = 494 Score = 78.6 bits (192), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 65/212 (30%), Positives = 105/212 (49%), Gaps = 17/212 (8%) Query: 258 DPNCPRDLTDCLLVEM--EKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLIL 315 D + +D LL M K+ + E L + I + AG ETTS L + L L Sbjct: 246 DRKASGEQSDDLLTHMLNGKDPETGEPLDD-ENIRYQIITFLIAGHETTSGLLSFALYFL 304 Query: 316 MKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRD 375 +K P + +K EE RV+ +P+ K +++ Y+ V++E R P+ A D Sbjct: 305 VKNPHVLQKAAEEAARVL-VDPVPSYKQVKQLKYVGMVLNEALRLWPTAPA-FSLYAKED 362 Query: 376 TIFRG-YLIPKGT---VVVPTL--DSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKP 429 T+ G Y + KG V++P L D ++ + D E+F+PE F N + +++ FKP Sbjct: 363 TVLGGEYPLEKGDELMVLIPQLHRDKTIWGD----DVEEFRPERFENPSAIPQHA--FKP 416 Query: 430 FSTGKRVCAGEGLARMELFLLLCAILQHFNLK 461 F G+R C G+ A E L+L +L+HF+ + Sbjct: 417 FGNGQRACIGQQFALHEATLVLGMMLKHFDFE 448 >6AYB-A nrPDB Length = 466 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 74/279 (26%), Positives = 131/279 (46%), Gaps = 29/279 (10%) Query: 224 FLHYLPGSHR-KVIKNVAEV-KEYVSERVKEHH---QSLDPNCPRDLTDCLLVEMEKEKH 278 F LP R K K V E+ +E + +R +EH + L D+ D LL + K+ Sbjct: 192 FYPSLPAPKRDKARKAVGEIFQELLDKRREEHKKHPERLLDESKMDVVDHLLTQKYKD-- 249 Query: 279 SAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRI 338 + L + I + +A LF AG T+S T + L+ ++ ++ EK+ +E + ++G ++ Sbjct: 250 -GQELTDVHRIGILIAGLF-AGQHTSSITSSWTLMNVISNKKVLEKVRKEQEEIMGSDKV 307 Query: 339 PAIKDRQEMPYMDAVVHEIQRF-----ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTL 393 +M Y++A + E R + + + P E + Y+IPKG ++V + Sbjct: 308 LDYDKVMKMDYLEACMKEALRMYPPLIMIMRMARKPRECEQ------YIIPKGNILVVSP 361 Query: 394 DSVLYDNQEFPDPEKFKPEHFL--NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLL 451 + +P+ F PE E+ KFKY PF G+ C GE A +++ ++ Sbjct: 362 SVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGAV--PFGAGRHKCIGENFALLQVKSII 419 Query: 452 CAILQHFNLKPLVDPKDIDLSPIHIGFGCIPP---RYKL 487 +L++F+++ + K D S + G PP RYKL Sbjct: 420 SILLRYFDMEYI--GKIPDPSYTSLVVGPSPPTRMRYKL 456 >3MDV-A nrPDB Length = 456 Score = 71.6 bits (174), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 100/423 (23%), Positives = 175/423 (41%), Gaps = 43/423 (10%) Query: 57 FTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD--YKDEFSGRGDLPAFHAHR--DR 112 F A+++GPV + V + V++ ++VK+ L+ Y + L R + Sbjct: 16 FLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ 75 Query: 113 GIIFN-NGPTWKDIRR-----FSLTTLRNYGMGKQGNESRIQREAHFLLEALR-KTQGQP 165 G++ N W RR FS ++L + + NE +A L+E L K GQ Sbjct: 76 GLVSECNYERWHKQRRVIDLAFSRSSL--VSLMETFNE-----KAEQLVEILEAKADGQT 128 Query: 166 FDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFL 225 P + + DIL + F L ++ L+ N FL Sbjct: 129 --PVSMQDMLTYTAM-DILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFL 185 Query: 226 HYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLD--PNCPRDLTDCLLVEMEKEKHSAERL 283 R+V +++ +++ + V+ ++L P D+ +L E + Sbjct: 186 PGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDD---- 241 Query: 284 YTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKD 343 +G+ F AG ET++ L + ++ L + PEI +L E+D VIG R +D Sbjct: 242 ---EGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFED 298 Query: 344 RQEMPYMDAVVHEIQRFITLVPSNLPHEAT-----RDTIFRGYLIPKGTVVVPTLDSVLY 398 + Y+ V+ E R L P P T +T+ G +P T ++ + + Sbjct: 299 LGRLQYLSQVLKESLR---LYP---PAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGR 352 Query: 399 DNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 + F DP F P+ F K +++ YF PFS G R C G+ A+ME+ +++ +LQ Sbjct: 353 MDTYFEDPLTFNPDRFGPGAPKPRFT-YF-PFSLGHRSCIGQQFAQMEVKVVMAKLLQRL 410 Query: 459 NLK 461 + Sbjct: 411 EFR 413 >3MZS-A nrPDB Length = 486 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 45/178 (25%), Positives = 83/178 (46%), Gaps = 6/178 (3%) Query: 286 MDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQ 345 ++ + + ++ G TTS TL++ L + + ++E L EE+ + K Q Sbjct: 274 LEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQ 333 Query: 346 EMPYMDAVVHEIQRF--ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF 403 +P + A + E R I++ P D + + YLIP T+V + ++ D F Sbjct: 334 MVPLLKASIKETLRLHPISVTLQRYPES---DLVLQDYLIPAKTLVQVAIYAMGRDPAFF 390 Query: 404 PDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 461 P+KF P +L+++ + F G R C G +A +E+ L L IL++F ++ Sbjct: 391 SSPDKFDPTRWLSKDKDLIHFRNLG-FGWGVRQCVGRRIAELEMTLFLIHILENFKVE 447 >3N9Z-A nrPDB Length = 487 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 44/179 (24%), Positives = 86/179 (48%), Gaps = 6/179 (3%) Query: 285 TMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDR 344 + + I V ++ G +TTS TL++ L + + ++++ L E+ ++ Sbjct: 272 SFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATML 331 Query: 345 QEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFP 404 Q +P + A + E R + + L D + R Y+IP T+V + ++ + F Sbjct: 332 QLVPLLKASIKETLR-LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFF 390 Query: 405 DPEKFKPEHFLNENGKFKYSDYFK--PFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 461 DPE F P +L+++ K YF+ F G R C G +A +E+ + L +L++F ++ Sbjct: 391 DPENFDPTRWLSKD---KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVE 446 >6M7X-A nrPDB Length = 484 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 97/398 (24%), Positives = 148/398 (37%), Gaps = 38/398 (9%) Query: 62 QRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDR-----GIIF 116 Q GP+F +G MV + + V E L R L + A+R G+ Sbjct: 50 QELGPIFRYDLGGAGMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFL 108 Query: 117 NNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAP 176 NGP W+ R L Q + A +AL+K Q + + P Sbjct: 109 LNGPEWR-FNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQP 167 Query: 177 CNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVI 236 F Y E + LF E L+ NF L + S +++ Sbjct: 168 SI----------FHYTIEA--SNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLM 215 Query: 237 KNVAEVKEYVSERV-KEHHQSLD------PNCPRDLTDCLLVEMEKEKHS--AERLYTM- 286 + + S +V KEH ++ D NC + + L ++ S AE L Sbjct: 216 FMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE 275 Query: 287 ---DGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKD 343 D I +L +TT L L L + P +++ L +E K Sbjct: 276 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKA 335 Query: 344 RQEMPYMDAVVHEIQRFITLVPSNLPHE--ATRDTIFRGYLIPKGTVVVPTLDSVLYDNQ 401 E+P + A + E R L P L E A+ D + + Y IP GT+V L S+ + Sbjct: 336 TTELPLLRAALKETLR---LYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPA 392 Query: 402 EFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAG 439 FP PE++ P+ +L+ G + + Y PF G R C G Sbjct: 393 LFPRPERYNPQRWLDIRGSGR-NFYHVPFGFGMRQCLG 429 >4ZGX-A nrPDB Length = 489 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 95/400 (23%), Positives = 152/400 (38%), Gaps = 42/400 (10%) Query: 62 QRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDR-----GIIF 116 Q GP+F +G RMV + + V E L R L + A+R G+ Sbjct: 50 QELGPIFRYNLGGPRMVCVMLPEDV-EKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFL 108 Query: 117 NNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAP 176 NGP W+ R L Q + A +AL+K Q + + P Sbjct: 109 LNGPEWR-FNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQP 167 Query: 177 CNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVI 236 F Y E + LF E L+ NF L + S +++ Sbjct: 168 SI----------FHYTIEA--SNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLM 215 Query: 237 KNVAEVKEYVSERV-KEHHQSLD------PNCPRDLTDCLLVEMEKEKH----SAERLY- 284 + ++S +V KEH ++ D NC + + L + +H AE L Sbjct: 216 FMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQEL--AFNRPQHYTGIVAELLLK 273 Query: 285 ---TMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAI 341 +++ I +L +TT+ L L L + P++++ L +E Sbjct: 274 AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQ 333 Query: 342 KDRQEMPYMDAVVHEIQRFITLVPSNLPHE--ATRDTIFRGYLIPKGTVVVPTLDSVLYD 399 K E+P + A + E R L P L E + D + + Y IP GT+V L S+ + Sbjct: 334 KATTELPLLRAALKETLR---LYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRN 390 Query: 400 NQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAG 439 FP PE++ P+ +L+ G + + PF G R C G Sbjct: 391 AALFPRPERYNPQRWLDIRGSGRNFHHV-PFGFGMRQCLG 429 >5VWS-A nrPDB Length = 393 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 100/391 (25%), Positives = 145/391 (37%), Gaps = 85/391 (21%) Query: 83 YKAVKEALLDYKDEFSGRGDL-PAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQ 141 Y V++ L DY+ S R L P GI + P + RR L T Sbjct: 46 YDDVRQILGDYQTFSSDRTRLMPTAQGFGKGGITMIDPPEHRHQRR--LITHAFTPQSIS 103 Query: 142 GNESRIQREAHFLLEALRKTQGQPFDPTFLIGCA-PCNVIADIL---------FRKHFDY 191 E RI++ A LL+ L G FD P VIA++L FR D Sbjct: 104 AMEPRIRQIADHLLDEL---PGPEFDLVEHFAYPLPVIVIAELLGVPPGDRHLFRTWSD- 159 Query: 192 NDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVK 251 RLM L EN+ + P L R V + E+ +Y+ E + Sbjct: 160 ------RLMSLQVENY---ADPELA----------------RTVAAAMTEMNDYLREHCR 194 Query: 252 EHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYG 311 PRD LV+ E E +RL ++ + T + L AG TT+ + Sbjct: 195 SRRTH-----PRDDLLTRLVQAEVE---GKRL-DLEEVVNTASLLLLAGHLTTTVLIGNT 245 Query: 312 LLILMKYPEIEEKLHEEIDRVIGPSRIPAIKD---RQEMPYMDAVVHEIQRFITLVPSNL 368 +L L +PE E+ + + PS IPA + R P++ A Sbjct: 246 MLCLWDHPEAEKAVRAD------PSLIPAALEESLRLRSPFLQA---------------- 283 Query: 369 PHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFK 428 TRD G IP V+ + S +D++ FPDPE+F + F + +F Sbjct: 284 GRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFDLHRQTTGHIAFGHGVHF- 342 Query: 429 PFSTGKRVCAGEGLARMELFLLLCAILQHFN 459 C G L R+E + L +L F Sbjct: 343 --------CLGAQLGRLEGRIALERLLGRFT 365 >2Y5N-A nrPDB Length = 417 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 55/230 (23%), Positives = 98/230 (42%), Gaps = 29/230 (12%) Query: 230 GSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGI 289 G+ + AE + +E+ + L ++ TD L+ + + + + L + + Sbjct: 186 GAFLSTAEVTAEEMQEAAEQAYAYMGDLIDRRRKEPTDDLVSALVQARDQQDSLSEQELL 245 Query: 290 TVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPY 349 + + L AG E+T+T + + +LM PE+ +L +DR P IP+ Sbjct: 246 DLAIG-LLVAGYESTTTQIADFVYLLMTRPELRRQL---LDR---PELIPS--------- 289 Query: 350 MDAVVHEIQRFITL-VPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEK 408 V E+ R++ L V + P A D RG I G V+ + + D +FPD ++ Sbjct: 290 ---AVEELTRWVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADR 346 Query: 409 FKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 + N++ F + G C G LAR+EL + L +LQ Sbjct: 347 IDVDRTPNQHLGFGH---------GVHHCLGAPLARVELQVALEVLLQRL 387 >6B11-A nrPDB Length = 440 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 49/186 (26%), Positives = 76/186 (40%), Gaps = 29/186 (15%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG ETT++ + +L+L+++P +L + P +P V Sbjct: 276 LLAAGHETTASMVTMSVLVLLQHPTAWREL------TVNPGLLPG------------AVD 317 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E+ R++++ L AT D G+ I G +V L + D F +PE F Sbjct: 318 ELLRYLSIA-DGLRRSATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHRSA 376 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF-NLKPLVDPKDIDLSPI 474 + F Y G C G+ LARMEL + L A+L+ L+P D + L Sbjct: 377 RRHVAFGY---------GPHQCLGQNLARMELEVALGAVLERLPALRPTTDVAGLRLKSD 427 Query: 475 HIGFGC 480 FG Sbjct: 428 SAVFGV 433 >2W0A-A nrPDB Length = 455 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 45/204 (22%), Positives = 91/204 (44%), Gaps = 13/204 (6%) Query: 263 RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE 322 RD+ D L+ + + ++ D IT + FAG T+S T + L+ LM++ + Sbjct: 223 RDMLDVLIA---VKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAY 279 Query: 323 EKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQR----FITLVPSNLPHEATRDTIF 378 + +E+D + G R + +++P ++ V+ E R I L+ A + Sbjct: 280 AAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIILM-----RVAKGEFEV 334 Query: 379 RGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY-FKPFSTGKRVC 437 +G+ I +G +V + ++FPDP F P + + + + + PF G+ C Sbjct: 335 QGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRC 394 Query: 438 AGEGLARMELFLLLCAILQHFNLK 461 G A M++ + +L+ + + Sbjct: 395 VGAAFAIMQIKAIFSVLLREYEFE 418 >3JUS-A nrPDB Length = 461 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 57/246 (23%), Positives = 107/246 (43%), Gaps = 18/246 (7%) Query: 228 LPG-----SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAER 282 LPG S R+ + E+K+ + +++ QS ++ D +L + + R Sbjct: 193 LPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQS------QEKIDDILQTLLDATYKDGR 246 Query: 283 LYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIK 342 T D + + L AG T+STT + L + +++K + E V G + P Sbjct: 247 PLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTY 306 Query: 343 DR-QEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKG--TVVVPTLDSVLYD 399 D+ +++ +D + E R + + T T+ GY IP G V PT++ L D Sbjct: 307 DQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTV-AGYTIPPGHQVCVSPTVNQRLKD 365 Query: 400 NQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFN 459 + + + F P+ +L +N + PF G+ C GE A +++ + +L+ + Sbjct: 366 S--WVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYE 423 Query: 460 LKPLVD 465 L+D Sbjct: 424 FD-LID 428 >3L4D-A nrPDB Length = 453 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 64/247 (25%), Positives = 113/247 (45%), Gaps = 22/247 (8%) Query: 228 LPGSHRKVIKNVAEVKEYVSERV--KEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYT 285 LP S+R AE+++ +SE + +E ++ DL LL + ++ R+ Sbjct: 195 LPQSYR-CRDARAELQDILSEIIIAREKEEAQKDTNTSDLLAGLLGAVYRD---GTRMSQ 250 Query: 286 MDGITVTVADLFFAGTETTSTTLRYGLLILM--KYPEIEEKLHEEIDRVIGPSRIPAIKD 343 + + VA +F AG T++ T + LL LM + KLH+EID P+++ Sbjct: 251 HEVCGMIVAAMF-AGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEIDEF--PAQLNYDNV 307 Query: 344 RQEMPYMDAVVHE-IQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQE 402 +EMP+ + E I+R LV L + + Y++P+G ++ + D + Sbjct: 308 MEEMPFAEQCARESIRRDPPLV--MLMRKVLKPVQVGKYVVPEGDIIACSPLLSHQDEEA 365 Query: 403 FPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFN--- 459 FP+P ++ PE N K F F G C GE +++ +L +L+ ++ Sbjct: 366 FPNPREWNPER----NMKL-VDGAFCGFGAGVHKCIGEKFGLLQVKTVLATVLRDYDFEL 420 Query: 460 LKPLVDP 466 L PL +P Sbjct: 421 LGPLPEP 427 >2WX2-A nrPDB Length = 473 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 56/231 (24%), Positives = 106/231 (45%), Gaps = 19/231 (8%) Query: 240 AEVKEYVSERV--KEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLF 297 AE+++ + E + +E ++ N DL LL + ++ + L+ + G+ V Sbjct: 220 AELQKILGEIIVAREKEEASKDNNTSDLLGGLLKAVYRDG-TRMSLHEVCGMIVAA---M 275 Query: 298 FAGTETTSTTLRYGLLILM--KYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 FAG T++ T + +L LM K + +KLH+EID P+++ EMP+ + V Sbjct: 276 FAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEF--PAQLNYDNVMDEMPFAERCVR 333 Query: 356 E-IQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHF 414 E I+R L+ + + Y++PKG ++ + +D + FP+P + PE Sbjct: 334 ESIRRDPPLL--MVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERD 391 Query: 415 LNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVD 465 +G F F G C G+ A +++ +L + ++ + L D Sbjct: 392 EKVDGA------FIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRD 436 >3TYW-A nrPDB Length = 417 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 48/190 (25%), Positives = 78/190 (41%), Gaps = 33/190 (17%) Query: 279 SAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRI 338 + E+L + GIT+ AG ETT++ + L+L+ PE+ +L ++ D Sbjct: 235 TTEQLLSTLGITIN------AGRETTTSMIALSTLLLLDRPELPAELRKDPD-------- 280 Query: 339 PAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLY 398 M A V E+ R +++ S A D G +P V+ L + Sbjct: 281 ----------LMPAAVDELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANH 330 Query: 399 DNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 D ++F DPE+ N + F Y G C G+ LAR+EL + L +L+ Sbjct: 331 DPEQFDDPERVDFHRTDNHHVAFGY---------GVHQCVGQHLARLELEVALETLLRRV 381 Query: 459 NLKPLVDPKD 468 L +D Sbjct: 382 PTLRLAGERD 391 >1WIY-A nrPDB Length = 389 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 48/182 (26%), Positives = 76/182 (41%), Gaps = 43/182 (23%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLH----------EEIDRVIGPSRIPAIKDRQ 345 L AG ET ++ L + L+L P+ ++++ +E R+ P+ I Sbjct: 218 LLVAGHETVASALTWSFLLLSHRPDWQKRVAESEEAALAAFQEALRLYPPAWI------- 270 Query: 346 EMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPD 405 + ++R + L LP T V+ P + LY FP+ Sbjct: 271 -------LTRRLERPLLLGEDRLPQGTT-------------LVLSPYVTQRLY----FPE 306 Query: 406 PEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVD 465 E F+PE FL E G S + PF G+R+C G A +E ++L A + F L PL Sbjct: 307 GEAFQPERFLAERGT--PSGRYFPFGLGQRLCLGRDFALLEGPIVLRAFFRRFRLDPLPF 364 Query: 466 PK 467 P+ Sbjct: 365 PR 366 >4TRI-A nrPDB Length = 407 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 56/254 (22%), Positives = 98/254 (38%), Gaps = 37/254 (14%) Query: 226 HYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYT 285 H + +K++ A E+ + + + P D +LV E E + Sbjct: 169 HVDEAAIQKLMDTFAAYTEFTKDVITKRRAE-----PTDDLFSVLVNSEVEGQR----MS 219 Query: 286 MDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQ 345 D I + G ETT TL G L+++ + + L ++D + G Sbjct: 220 DDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVDLLPG----------- 268 Query: 346 EMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPD 405 + E+ R+ + V N+ T DT+F G + G ++ +S +D F D Sbjct: 269 -------AIEEMLRWTSPV-KNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGD 320 Query: 406 PEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVD 465 P+ F+ + N + F + +F C G LAR+EL L+ +L+ L D Sbjct: 321 PDNFRIDRNPNSHVAFGFGTHF---------CLGNQLARLELRLMTERVLRRLPDLRLAD 371 Query: 466 PKDIDLSPIHIGFG 479 + L P + G Sbjct: 372 DAPVPLRPANFVSG 385 >5FSA-A nrPDB Length = 490 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 107/476 (22%), Positives = 189/476 (39%), Gaps = 118/476 (24%) Query: 57 FTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGI-I 115 F Q++G VF+ + + M V G K E + + K D+ A A++ + Sbjct: 30 FESCRQKYGDVFSFMLLGKIMTVYLGPKG-HEFVFNAK-----LSDVSAEEAYKHLTTPV 83 Query: 116 FNNGPTW----------KDIRRFSLTT-------------LRNYGMGKQGNESRIQREAH 152 F G + K +F+LTT + NY + +ES +E Sbjct: 84 FGTGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVT---DESFKLKEKT 140 Query: 153 FLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLST 212 + + KTQ P I A ++ D + R+ FD F +L ++ F T Sbjct: 141 HGVANVMKTQ-----PEITIFTASRSLFGDEM-RRIFD---RSFAQLYSDLDKGF----T 187 Query: 213 PWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSE-RVKEHHQSLDPNCPRDLTDCLLV 271 P ++ N P LP R+ Y+ E +++ +DPN RDL D LL+ Sbjct: 188 PINFVFPNLP-----LPHYWRRDAAQKKISATYMKEIKLRRERGDIDPN--RDLIDSLLI 240 Query: 272 EMEKEKHSAERLYTMDGITVT---VADLF----FAGTETTSTTLRYGLLILMKYPEIEEK 324 HS + DG+ +T +A+L G T+++T + LL L + P +++ Sbjct: 241 ------HSTYK----DGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDV 290 Query: 325 LHEEIDRVI----GPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFR- 379 +++E+ ++ G +D Q++P ++ + E R ++P + IFR Sbjct: 291 IYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRM------HMPLHS----IFRK 340 Query: 380 ----------GYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHF-----------LNEN 418 Y++PKG V+ + + F +PE F P + N + Sbjct: 341 VTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSS 400 Query: 419 GKFKY---------SDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVD 465 + Y S + PF G+ C GE A ++L +L + +NL+ +D Sbjct: 401 DEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFV--YNLRWTID 454 >3IVY-A nrPDB Length = 433 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 52/206 (25%), Positives = 83/206 (40%), Gaps = 31/206 (15%) Query: 263 RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE 322 ++ D ++ ++ + E+L + D V L AG ETT ++ G++ ++P+ Sbjct: 233 KNPADDIVTQLIQADIDGEKL-SDDEFGFFVVMLAVAGNETTRNSITQGMMAFAEHPD-- 289 Query: 323 EKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYL 382 E+ + + P + EI R+ T V + A RD G Sbjct: 290 ---QWELYKKVRP---------------ETAADEIVRWATPVTA-FQRTALRDYELSGVQ 330 Query: 383 IPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGL 442 I KG VV S +D + F DP F N + F TG C G L Sbjct: 331 IKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFG--------GTGAHYCIGANL 382 Query: 443 ARMELFLLLCAILQHF-NLKPLVDPK 467 ARM + L+ A+ H +LKP+ P+ Sbjct: 383 ARMTINLIFNAVADHMPDLKPISAPE 408 >2X2N-A nrPDB Length = 475 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 45/186 (24%), Positives = 82/186 (44%), Gaps = 16/186 (8%) Query: 283 LYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE--EKLHEEIDRVIGPSRIPA 340 L+ + G+ V FAG T+S T + +L LM ++ E L +EI+ P+++ Sbjct: 264 LHEVCGMIVAA---MFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEF--PAQLNY 318 Query: 341 IKDRQEMPYMDAVVHE-IQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYD 399 EMP+ + E I+R L+ L + D Y++PKG ++ + +D Sbjct: 319 NNVMDEMPFAERCARESIRRDPPLL--MLMRKVMADVKVGSYVVPKGDIIACSPLLSHHD 376 Query: 400 NQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFN 459 + FP+P ++ PE K F F G C G+ +++ +L + ++ Sbjct: 377 EEAFPEPRRWDPER------DEKVEGAFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYD 430 Query: 460 LKPLVD 465 + L D Sbjct: 431 FQLLRD 436 >3SN5-A nrPDB Length = 491 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 48/210 (22%), Positives = 84/210 (40%), Gaps = 22/210 (10%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI----------GPSRIPAIKDRQ 345 + +A T + L +++ PE + EE+ R + G + + Sbjct: 265 VLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELN 324 Query: 346 EMPYMDAVVHEIQRF--ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF 403 ++P +D+++ E R +L + T Y I K ++ + D + + Sbjct: 325 DLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIY 384 Query: 404 PDPEKFKPEHFLNENGK---------FKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAI 454 PDP FK + +L+ENGK K Y+ PF +G +C G A E+ L + Sbjct: 385 PDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILM 444 Query: 455 LQHFNLKPLV-DPKDIDLSPIHIGFGCIPP 483 L +F L+ + K L G G +PP Sbjct: 445 LSYFELELIEGQAKCPPLDQSRAGLGILPP 474 >5DQN-A nrPDB Length = 426 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 48/173 (27%), Positives = 69/173 (39%), Gaps = 30/173 (17%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG ETT ++ +G++ + P+ E ++E P + Sbjct: 248 LAVAGNETTRNSITHGMIAFAQNPDQWELY------------------KKERP--ETAAD 287 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 EI R+ T V S A D G I KG VV + S +D + F DP F Sbjct: 288 EIVRWATPV-SAFQRTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNILRSP 346 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF-NLKPLVDPK 467 N + F TG C G LARM + L+ AI + +LKP+ P+ Sbjct: 347 NPHVGFG--------GTGAHYCIGANLARMTINLIFNAIADNMPDLKPIGAPE 391 >4WMZ-A nrPDB Length = 539 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 60/234 (25%), Positives = 103/234 (44%), Gaps = 40/234 (17%) Query: 250 VKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVT---VADLF----FAGTE 302 +KE ++ D RDL D L+ K+S + DG+ +T +A+L G Sbjct: 269 IKERRKNNDIQ-DRDLIDSLM------KNSTYK----DGVKMTDQEIANLLIGVLMGGQH 317 Query: 303 TTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKD-RQEMPYMDAVVHEIQRFI 361 T++ T + LL L + P+++++L+EE RV+ + D QEMP ++ + E R Sbjct: 318 TSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMH 377 Query: 362 TLVPSNLPHEATRDTIF--RGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENG 419 + S L + +D Y+IP G V+ + ++ FP+ +F H N + Sbjct: 378 HPLHS-LFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNI-HRWNNDS 435 Query: 420 KFKYS-----DY------------FKPFSTGKRVCAGEGLARMELFLLLCAILQ 456 YS DY + PF G+ C GE A +L +L+ ++ Sbjct: 436 ASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIR 489 >6CR2-A nrPDB Length = 477 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 47/193 (24%), Positives = 79/193 (40%), Gaps = 32/193 (16%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDR-QEMPYMDAVV 354 L AG ++S+T + +L L P+I E+L++E RV+G P D Q++ V+ Sbjct: 258 LLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLHAKVI 317 Query: 355 HE-------IQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE 407 E I I V + + + T Y+IP V+ + + FP+P Sbjct: 318 KETLRLHAPIHSIIRAVKNPMAVDGT------SYVIPTSHNVLSSPGVTARSEEHFPNPL 371 Query: 408 KFKPEHFLNENGKFKYSDYFK-----------------PFSTGKRVCAGEGLARMELFLL 450 ++ P H +EN D K PF G+ C GE A ++L + Sbjct: 372 EWNP-HRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTI 430 Query: 451 LCAILQHFNLKPL 463 +++ F + L Sbjct: 431 TAVLVRLFRFRNL 443 >5YSW-A nrPDB Length = 441 Score = 48.9 bits (115), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 59/255 (23%), Positives = 106/255 (41%), Gaps = 52/255 (20%) Query: 234 KVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTV 293 + +KN ++ ++ V + N D+ L+ H+ D + + Sbjct: 221 EAVKNADALRAFMQALVTDKRA----NPAGDIISGLI------HHAGADPALTDDELINI 270 Query: 294 ADLFF-AGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDA 352 A+L AG +TT++ L G+ +L++ P L ++ PSRI DA Sbjct: 271 ANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDD------PSRI-----------ADA 313 Query: 353 VVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPE 412 V E+ R++++V + A D F G IP G+ VV ++ + D + +PDP+ Sbjct: 314 V-EELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDPDL---- 368 Query: 413 HFLNENGKFKYSDYFKP------FSTGKRVCAGEGLARMELFLLLCAILQHF-NLKPLVD 465 D +P F G C G+ LARME+ +L+ N++ V Sbjct: 369 ------------DLTRPRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVP 416 Query: 466 PKDIDLSPIHIGFGC 480 P+++ L + +G Sbjct: 417 PEEVPLRNDMLTYGV 431 >2IJ7-A nrPDB Length = 396 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 50/206 (24%), Positives = 83/206 (40%), Gaps = 27/206 (13%) Query: 264 DLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFF-AGTETTSTTLRYGLLILMKYPEIE 322 ++T L+ E+ + + + D + T+ FF AG +T + L L+ L++ P++ Sbjct: 197 NITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLR 256 Query: 323 EKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYL 382 LHE+ P IPA V E+ R LP AT D L Sbjct: 257 NLLHEK------PELIPA------------GVEELLRINLSFADGLPRLATADIQVGDVL 298 Query: 383 IPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGL 442 + KG +V+ L+ +D + FP+P E + + + F G+ C G L Sbjct: 299 VRKGELVLVLLEGANFDPEHFPNPGSI-------ELDRPNPTSHLA-FGRGQHFCPGSAL 350 Query: 443 ARMELFLLLCAILQHFNLKPLVDPKD 468 R + + A+L+ L P D Sbjct: 351 GRRHAQIGIEALLKKMPGVDLAVPID 376 >4YZR-A nrPDB Length = 405 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 61/256 (23%), Positives = 107/256 (41%), Gaps = 41/256 (16%) Query: 216 QLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLL-VEME 274 Q++ N + + G+ + + E K+Y+++ + H + + P DL L+ E Sbjct: 169 QIWTN--AMVDTSEGNRELTNQALREFKDYIAKLI--HDRRIKPK--DDLISKLVHAEEN 222 Query: 275 KEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIG 334 K S + LY+M + V AG ETT L G L L+++ + EKL Sbjct: 223 GSKLSEKELYSMLFLLVV------AGLETTVNLLGSGTLALLQHKKECEKL--------- 267 Query: 335 PSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLD 394 +Q+ + V E+ R+ + V A D ++G+ I +G ++ + Sbjct: 268 ---------KQQPEMIATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIG 318 Query: 395 SVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAI 454 S D F +PE N + F + +F C G LAR+E + A+ Sbjct: 319 SANRDPNFFENPEILNINRSPNRHISFGFGIHF---------CLGAPLARLEGHIAFKAL 369 Query: 455 LQHF-NLKPLVDPKDI 469 L+ F +++ V P DI Sbjct: 370 LKRFPDIELAVAPDDI 385 >2XKR-A nrPDB Length = 398 Score = 48.1 bits (113), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 54/217 (24%), Positives = 90/217 (41%), Gaps = 30/217 (13%) Query: 264 DLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEE 323 D TD L+ + + ERL + D + + + G ETT TL G L++ + + Sbjct: 196 DPTDDLVSVLVSSEVDGERL-SDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWD 254 Query: 324 KLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLI 383 L + PS +P + E+ R+ V N+ T DT F G + Sbjct: 255 LLQRD------PSLLPG------------AIEEMLRWTAPV-KNMCRVLTADTEFHGTAL 295 Query: 384 PKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLA 443 G ++ +S +D F +PEKF + N + F + +F C G LA Sbjct: 296 CAGEKMMLLFESANFDEAVFCEPEKFDVQRNPNSHLAFGFGTHF---------CLGNQLA 346 Query: 444 RMELFLLLCAILQHF-NLKPLVDPKDIDLSPIHIGFG 479 R+EL L+ +L+ +L+ + D + L P + G Sbjct: 347 RLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSG 383 >5LIE-A nrPDB Length = 414 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 48/186 (25%), Positives = 71/186 (38%), Gaps = 34/186 (18%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 LF AG ETT ++ GLL L + P+ + L R + + + Sbjct: 250 LFSAGAETTRNSIAGGLLALAENPDQLQTL------------------RSDFELLPTAIE 291 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 EI R+ + PS A+R G I G VV +++ DP F Sbjct: 292 EIVRWTSPSPSKR-RTASRAVSLGGQPIEAGQKVV------VWEGSANRDPSVF------ 338 Query: 416 NENGKFKYSDYFKP---FSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLS 472 + +F + P F G C G LAR+EL +L +L F +V+P + S Sbjct: 339 DRADEFDITRKPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVVEPAEWTRS 398 Query: 473 PIHIGF 478 H G Sbjct: 399 NRHTGI 404 >3MGX-A nrPDB Length = 415 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 67/175 (38%), Gaps = 28/175 (16%) Query: 285 TMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDR 344 T+D + + ++ G ETT + + L P + L R Sbjct: 240 TIDDVLLNCDNVLIGGNETTRHAITGAVHALATVPGLLTAL------------------R 281 Query: 345 QEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFP 404 +D VV E+ R+ T ++ T D G +P GT VV L + D EF Sbjct: 282 DGSADVDTVVEEVLRW-TSPAMHVLRVTTADVTINGRDLPSGTPVVAWLPAANRDPAEFD 340 Query: 405 DPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFN 459 DP+ F P N + F + G C G LAR+EL ++L + + + Sbjct: 341 DPDTFLPGRKPNRHITFGH---------GMHHCLGSALARIELSVVLRVLAERVS 386 >4RM4-A nrPDB Length = 396 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 53/201 (26%), Positives = 78/201 (38%), Gaps = 36/201 (17%) Query: 260 NCPRDLTDCLLVEMEK--EKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMK 317 N P +LVE E+ EK S E L + L AG ETT+ + + +++ Sbjct: 204 NKPEQDIISILVEAEETGEKLSGEELIPFCTL------LLVAGNETTTNLISNAMYSILE 257 Query: 318 YPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTI 377 P + E+L R M V E RF P L A RDT Sbjct: 258 TPGVYEEL------------------RSHPELMPQAVEEALRFRAPAPV-LRRIAKRDTE 298 Query: 378 FRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVC 437 G+LI +G +V+ + S D +F P F N + F + +F C Sbjct: 299 IGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRRHPNPHIAFGHGIHF---------C 349 Query: 438 AGEGLARMELFLLLCAILQHF 458 G LAR+E + L +++ F Sbjct: 350 LGAPLARLEANIALTSLISAF 370 >4GGV-A nrPDB Length = 418 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 60/228 (26%), Positives = 94/228 (41%), Gaps = 41/228 (17%) Query: 233 RKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVT 292 R + + + +Y++ V E ++ PR+ LL + + + ERL D V Sbjct: 200 RDATERLRPLLDYMAGHVTERRRT-----PRE---DLLTHLVQAEVDGERL--TDNEIVN 249 Query: 293 VAD-LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMD 351 VA+ L G TT+ TL +L L PE+ K+ DR +P Sbjct: 250 VANILLVTGHITTTMTLGNTVLCLDADPEVAAKVR---------------ADRSLVP--- 291 Query: 352 AVVHEIQRFITLVPSN-LPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410 + E R ++ PS L +R+ G +IPK +V+ L + D ++F DPE + Sbjct: 292 GAIEEALRVLS--PSAALARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYD 349 Query: 411 PEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 P + N F F G C G LAR+E + L A+ F Sbjct: 350 PTR--DPNPHFG-------FGRGIHFCLGAPLARLEGRVALNALFDRF 388 >6GMF-A nrPDB Length = 397 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 49/204 (24%), Positives = 78/204 (38%), Gaps = 52/204 (25%) Query: 265 LTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEK 324 ++ L E++ EK +A + + L AG ETT++ + L+ L +PE Sbjct: 205 ISQLLAAEVDGEKLTAGEVLSFANT------LLIAGNETTTSLIGNALVALTDHPEQLAA 258 Query: 325 LHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYL-- 382 ++ S +PA VV E+ R+ E+ IFR + Sbjct: 259 AQADL------SLVPA------------VVEEVLRY----------ESPAQCIFRQTMTD 290 Query: 383 -------IPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKR 435 IP +VV+P L S D FPDP++F + F +F Sbjct: 291 VEIGDERIPARSVVLPLLASANRDESRFPDPDRFDIHRDTKGHLAFGLDIHF-------- 342 Query: 436 VCAGEGLARMELFLLLCAILQHFN 459 C G LAR+E ++L +L Sbjct: 343 -CIGAPLARLEAKVMLEVLLARLG 365 >6F88-A nrPDB Length = 400 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 51/198 (25%), Positives = 76/198 (38%), Gaps = 32/198 (16%) Query: 263 RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE 322 RD +D LL E+ + AE + T++ V L G ETTS + + L+ +P+ Sbjct: 194 RDTSDTLLGEILR-TLKAEHMDTIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTL 252 Query: 323 EKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLP--HEATRDTIFRG 380 ++ ++ PS +PA I+ + PSN RD Sbjct: 253 ARVRQD------PSLLPA---------------AIEEGMRWCPSNFGVLRMVERDVRLDD 291 Query: 381 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 440 + GTVV + YD +P PE + + K F G C G Sbjct: 292 QALSAGTVVCLAGIAGNYDETAYPSPEVYDIDR--------KPLPAANVFGGGAHFCVGA 343 Query: 441 GLARMELFLLLCAILQHF 458 LARME + L A+L F Sbjct: 344 PLARMEARVGLQALLARF 361 >3A1L-A nrPDB Length = 425 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 46/172 (26%), Positives = 68/172 (39%), Gaps = 28/172 (16%) Query: 285 TMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDR 344 ++DGI T L AG ETT+ L +L L + ++ ++L P PA Sbjct: 240 SVDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELR------TTPESTPAAV-- 291 Query: 345 QEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFP 404 +E+ D V + R+ A D + IP+G+ VV L S D FP Sbjct: 292 EELMRYDPPVQAVTRW-----------AYEDIRLGDHDIPRGSRVVALLGSANRDPARFP 340 Query: 405 DPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQ 456 DP+ + ++ F G C G LAR E + L A+L Sbjct: 341 DPDVLD---------VHRAAERQVGFGLGIHYCLGATLARAEAEIGLRALLD 383 >5JLC-A nrPDB Length = 515 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 50/219 (22%), Positives = 87/219 (39%), Gaps = 34/219 (15%) Query: 263 RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE 322 RDL D L M+ + T I + + G T++ T + LL L + P+++ Sbjct: 263 RDLIDEL---MKNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQ 319 Query: 323 EKLHEEIDRVI-GPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGY 381 E+L++E RV+ ++ D Q MP ++ ++ E R + P + + R Sbjct: 320 EELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRL------HHPLHSLFRKVMRDV 373 Query: 382 LIPKGTVVVPTLDSVLYD-------NQEFPDPEKFKPEHFLNENGKFKYS-----DY--- 426 IP + VVP VL + FP P +F + + + DY Sbjct: 374 AIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFG 433 Query: 427 ---------FKPFSTGKRVCAGEGLARMELFLLLCAILQ 456 + PF G+ C GE A +L +L+ ++ Sbjct: 434 AISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIR 472 >6GK6-A nrPDB Length = 411 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 50/201 (24%), Positives = 77/201 (38%), Gaps = 35/201 (17%) Query: 260 NCPRD--LTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMK 317 PRD ++ LL E ++ K S L +M V L AG ETT + G+L+L+ Sbjct: 208 KAPRDDLISGLLLAEEQEHKLSPAELSSM------VFLLLVAGHETTVHLIASGMLLLLS 261 Query: 318 YPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTI 377 +P +L E+ P + + + V E R + + D Sbjct: 262 HPAERRRLDED----------PGL--------VGSAVEEALRCEGPAELSTIRWSLEDIE 303 Query: 378 FRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVC 437 G +P G V L + D Q FPDP++F N + F +F C Sbjct: 304 LFGARVPAGEGVAAGLLAANRDPQHFPDPDRFDIGRSPNRHIGFGGGIHF---------C 354 Query: 438 AGEGLARMELFLLLCAILQHF 458 G LAR+E + +L+ Sbjct: 355 LGAMLARIEAAIAFSTLLRRL 375 >5EX6-C nrPDB Length = 434 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 40/171 (23%), Positives = 69/171 (40%), Gaps = 27/171 (15%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 + AG + S + G+L L++ PE +I A+ R ++P + V Sbjct: 269 MMLAGDDNISGMIGLGVLALLRNPE----------------QIAAL--RGDVPAAERAVD 310 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E+ R++T+ + P A D+ +I G V+ +L + D PD ++ Sbjct: 311 ELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADRLD----- 365 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDP 466 + + F G C G LAR+EL + A+ + F L DP Sbjct: 366 ----VTREAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLADP 412 >6F0B-A nrPDB Length = 395 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 43/169 (25%), Positives = 66/169 (39%), Gaps = 39/169 (23%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L G +TT++T+ L+ PE +HE P RIP + V Sbjct: 230 LIVGGYDTTASTISLSLVSYALQPEKFSVVHEH------PERIPLL------------VE 271 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E+ R+ T+ L AT D G + G +VV L D FP+P++ Sbjct: 272 ELLRYHTVSQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDEL------ 325 Query: 416 NENGKFKYSDYFKP------FSTGKRVCAGEGLARMELFLLLCAILQHF 458 D+ +P F G C G+ LAR+EL + A+++ Sbjct: 326 ---------DFDRPSVPHVGFGYGPHQCVGQALARVELQEAIPAVIRRL 365 >5Y1I-A nrPDB Length = 403 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 53/246 (21%), Positives = 91/246 (36%), Gaps = 38/246 (15%) Query: 214 WLQLYNNFPSFLHYLPGSHRKV-IKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVE 272 +LQ NN + G +K I +KE V ++ D D +L + Sbjct: 165 FLQQNNNAMIYRDTAQGDAQKAAIAQAMYLKELVGTKLG------------DRGDDILSD 212 Query: 273 MEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRV 332 + + + E T D L AG ETT+ + G L L++ PE Sbjct: 213 LAVQVEAGE--ITQDDAAGIGMMLLGAGHETTANMIALGTLALLENPE------------ 258 Query: 333 IGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPT 392 ++ ++D + + V E+ R++T+ + A D G +I G +V Sbjct: 259 ----QLAEVRDSDDPKVIVNTVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFP 314 Query: 393 LDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLC 452 L++ +D +P+ H N F G C G LAR+EL ++ Sbjct: 315 LNAANWDPDLYPEAPDRLDIHRANARRHLA-------FGYGVHQCLGATLARVELQIVYS 367 Query: 453 AILQHF 458 +L+ Sbjct: 368 TLLRRI 373 >2VZM-A nrPDB Length = 436 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 46/194 (23%), Positives = 75/194 (38%), Gaps = 30/194 (15%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG ETT + G+ L+ +P+ L R +M +D V Sbjct: 260 LLVAGHETTVNLIANGMYALLSHPDQLAAL------------------RADMTLLDGAVE 301 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E+ R+ V S G +IP G V+ L + FPDP +F Sbjct: 302 EMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDT 361 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF-NLKPLVDPKDIDL--S 472 + F + +F C G LAR+E + + A+L+ +L V P ++ + Sbjct: 362 AGHLAFGHGIHF---------CIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPN 412 Query: 473 PIHIGFGCIPPRYK 486 P+ G +P R++ Sbjct: 413 PMIRGLKALPIRWR 426 >4WPZ-A nrPDB Length = 397 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 45/166 (27%), Positives = 70/166 (42%), Gaps = 30/166 (18%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 + AG ETT+ + L+ L+ PE +KL + +R+ +P V Sbjct: 229 ILSAGHETTANQISMFLVTLLHNPEELDKLRD---------------NREAIPK---AVD 270 Query: 356 EIQRFITLVPSN--LPHEATRDT-IFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPE 412 E+ RF+ L + +P T + + G ++P G VV+P + + D + F D E+ Sbjct: 271 ELLRFVPLTTTGGIIPRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERL--- 327 Query: 413 HFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 + EN F G C G LAR+EL L AIL Sbjct: 328 NVTRENNPHLA------FGAGIHHCLGAQLARIELQEALGAILDRM 367 >1Q5D-A nrPDB Length = 419 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 51/213 (23%), Positives = 84/213 (39%), Gaps = 28/213 (13%) Query: 246 VSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTS 305 V+E + H LD L + +L + + + RL T + + V + AGT+TT Sbjct: 202 VTEGLALLHGVLDERRRNPLENDVLTMLLQAEADGSRLSTKE-LVALVGAIIAAGTDTTI 260 Query: 306 TTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVP 365 + + +L L++ PE E + E P + M + E+ RF ++ Sbjct: 261 YLIAFAVLNLLRSPEALELVKAE----------PGL--------MRNALDEVLRFDNILR 302 Query: 366 SNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSD 425 A +D + G I KG +V + S L D F P+ F + + Y Sbjct: 303 IGTVRFARQDLEYCGASIKKGEMVFLLIPSALRDGTVFSRPDVFDVRR--DTSASLAY-- 358 Query: 426 YFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 G VC G LAR+E + + I + F Sbjct: 359 -----GRGPHVCPGVSLARLEAEIAVGTIFRRF 386 >2Z36-A nrPDB Length = 413 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 40/152 (26%), Positives = 58/152 (38%), Gaps = 27/152 (17%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG ETT+ + G++ L+ +PE + P R P V Sbjct: 242 LLTAGHETTANMISLGVVGLLSHPEQLTVVKAN------PGRTPM------------AVE 283 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E+ R+ T+ AT D G I G V+ ++ S +D F DP E Sbjct: 284 ELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVE--- 340 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMEL 447 + + + F G C G+ LARMEL Sbjct: 341 ------RGARHHLAFGFGPHQCLGQNLARMEL 366 >3TKT-A nrPDB Length = 450 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 42/147 (28%), Positives = 63/147 (42%), Gaps = 15/147 (10%) Query: 343 DRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQE 402 DR +P +V E R+ T V + A DT G I G ++ + +D + Sbjct: 318 DRNLLP---GIVEEAIRWTTPV-QHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQ 373 Query: 403 FPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKP 462 FP+P KF P N + F G C G LAR+E+ +LL +L + Sbjct: 374 FPEPRKFDPTRPANRH---------LAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLE 424 Query: 463 LV-DPKDIDLSPIHIGFGCIPPRYKLC 488 L +PK ++ S GF +P R+K Sbjct: 425 LAGEPKRVN-STFVGGFKSLPMRWKAA 450 >5NWS-A nrPDB Length = 435 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 49/202 (24%), Positives = 83/202 (41%), Gaps = 25/202 (12%) Query: 265 LTDCLLVEM-EKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEE 323 LTD LL E+ + RL ++ +T+ + L AG ET++ + G L+ +P Sbjct: 233 LTDDLLSELIRAQDDDGGRLSDIETVTMILT-LVLAGHETSAHLIGNGTAALLTHPGQWA 291 Query: 324 KLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLI 383 L ++ PA+ R VHE+ R+ V AT D G + Sbjct: 292 LLRKD----------PALLPR--------AVHELMRWCGSVHVARLRYATEDLELAGTPV 333 Query: 384 PKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLA 443 +G V L S +D + + DP++ + + + + ++ F G C G LA Sbjct: 334 ARGDAVQLVLVSANFDPRHYSDPDRLD----ITRHQEGQAENHVG-FGHGIHYCLGATLA 388 Query: 444 RMELFLLLCAILQHFNLKPLVD 465 R E + L +L+ + L D Sbjct: 389 RQEGEVALARLLETYPDLALAD 410 >4OQR-A nrPDB Length = 457 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 46/187 (24%), Positives = 77/187 (41%), Gaps = 33/187 (17%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG ETT+ L G L+++P E+I + P V Sbjct: 276 LLVAGHETTANMLGLGTFALLQHP-------EQIANLDSPD----------------AVE 312 Query: 356 EIQRFITLVPSNLPHEAT-RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHF 414 E+ R++++V P+ A D G +I KG V L +V D + F +P+ + Sbjct: 313 ELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQ---- 368 Query: 415 LNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF-NLKPLVDPKDIDLSP 473 L+ K++ F G C G+ LAR+E+ + + F +L+ V ++I L Sbjct: 369 LDRVDARKHA----AFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKLRE 424 Query: 474 IHIGFGC 480 +G Sbjct: 425 KSAAYGV 431 >5LIV-A nrPDB Length = 450 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 50/198 (25%), Positives = 76/198 (38%), Gaps = 32/198 (16%) Query: 263 RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE 322 RD +D LL E+ + AE + T++ V L G ETTS + + L+ +P+ Sbjct: 244 RDTSDTLLGEILR-TLKAEHMDTIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTL 302 Query: 323 EKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLP--HEATRDTIFRG 380 ++ ++ PS +PA I+ + PS+ RD Sbjct: 303 ARVRQD------PSLLPAA---------------IEEGMRWCPSSFGVLRMVERDVRLDD 341 Query: 381 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 440 + GTVV + YD +P PE + + K F G C G Sbjct: 342 QALSAGTVVCLAGIAGNYDETAYPSPEVYDIDR--------KPLPAANVFGGGAHFCVGA 393 Query: 441 GLARMELFLLLCAILQHF 458 LARME + L A+L F Sbjct: 394 PLARMEARVGLQALLARF 411 >3WVS-A nrPDB Length = 401 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 45/164 (27%), Positives = 69/164 (42%), Gaps = 28/164 (17%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG ETT++ + + L+ P+ ++L ++ P IP+ V Sbjct: 238 LLIAGHETTASQIPSFVYALLDQPQHWKRLLDD------PELIPS------------AVE 279 Query: 356 EIQRFITL-VPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHF 414 E+ RF+ L S P A D G L+ G V+ L + D F DPE+ K + Sbjct: 280 ELFRFVPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVALGAANRDGLRFEDPEEIKLD-- 337 Query: 415 LNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 + S++ F G C G LAR+EL L A+L+ Sbjct: 338 -------RPSNHHIGFGHGIHHCLGAPLARLELQEALRALLERL 374 >5DE9-A nrPDB Length = 410 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 47/182 (25%), Positives = 73/182 (40%), Gaps = 29/182 (15%) Query: 290 TVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPY 349 V +A L G E + +L+ PE+ E+L E P I+ R Sbjct: 232 AVGLAVLLQIGGEAVTNNSGQMFHLLLSRPELAERLRSE----------PEIRPR----- 276 Query: 350 MDAVVHEIQRFITLVPS-NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEK 408 + E+ R+I + L A D +G I G V + + D + FPDP++ Sbjct: 277 ---AIDELLRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDR 333 Query: 409 FKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF-NLKPLVDPK 467 E N + F + ++ C G LAR+E LL+ A+L LK V P+ Sbjct: 334 IDFERSPNPHVSFGFGPHY---------CPGGMLARLESELLVDAVLDRVPGLKLAVAPE 384 Query: 468 DI 469 D+ Sbjct: 385 DV 386 >6CVC-A nrPDB Length = 433 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 73/306 (23%), Positives = 112/306 (36%), Gaps = 56/306 (18%) Query: 144 ESRIQREAHFLLEALRKTQ--GQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMY 201 E+ ++ AH L+ A+ + GQ + L G P +I D++ D+ Sbjct: 142 EASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGIPEEDHE--------Q 193 Query: 202 LFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNC 261 +F+ +L L +F FL I A +R HH Sbjct: 194 IFHWTNVILGFGDPDLTTDFDEFLQV-----SMAIGGYATA--LADDRRVNHHG------ 240 Query: 262 PRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEI 321 DLT L VE E + ERL + + I + L AG ETT + +G+L L +YP+ Sbjct: 241 --DLTTSL-VEAEVD---GERLSSSE-IAMFFILLVVAGNETTRNAISHGMLALSRYPDE 293 Query: 322 EEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGY 381 K + D + + V EI R+ + V + ++D RG Sbjct: 294 RAKWWSDFDGLAATA-----------------VEEIVRWASPV-VYMRRTLSQDVDLRGT 335 Query: 382 LIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEG 441 + G V S D ++F DP F N N + + G C G Sbjct: 336 KMAAGDKVTLWYCSANRDEEKFADPWTFDVTR--NPNPQVGFG------GGGAHFCLGAN 387 Query: 442 LARMEL 447 LAR E+ Sbjct: 388 LARREI 393 >1UED-A nrPDB Length = 406 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 41/163 (25%), Positives = 66/163 (40%), Gaps = 27/163 (16%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L G ET + + +G+L L+ P E L E ++ + VV+ Sbjct: 242 LILGGVETVAGMIGFGVLALLDNPGQIELLFESPEKA------------------ERVVN 283 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E+ R+++ V + P A +D + G LI G V+ ++ D PDP+ L Sbjct: 284 ELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPD------VL 337 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 + N + SD F G C G LAR L + + + F Sbjct: 338 DAN-RAAVSDV--GFGHGIHYCVGAALARSMLRMAYQTLWRRF 377 >4OQS-A nrPDB Length = 433 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 46/187 (24%), Positives = 77/187 (41%), Gaps = 33/187 (17%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG ETT+ L G L+++P E+I + P V Sbjct: 237 LLVAGHETTANMLGLGTFALLQHP-------EQIAALDSPD----------------AVE 273 Query: 356 EIQRFITLVPSNLPHEAT-RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHF 414 E+ R++++V P+ A D G +I KG V L +V D + F +P+ + Sbjct: 274 ELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQ---- 329 Query: 415 LNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF-NLKPLVDPKDIDLSP 473 L+ K++ F G C G+ LAR+E+ + + F +L+ V ++I L Sbjct: 330 LDRVDARKHA----AFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKLRE 385 Query: 474 IHIGFGC 480 +G Sbjct: 386 KSAAYGV 392 >6FSH-A nrPDB Length = 398 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 39/171 (22%), Positives = 67/171 (39%), Gaps = 27/171 (15%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG + S + G+L L+++PE +I A+ R + D V Sbjct: 233 LMLAGDDNVSGMIGLGVLALLRHPE----------------QIAAL--RGDDQSADRAVD 274 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E+ R++T+ + P A D + +I +G V+ +L D PD ++ Sbjct: 275 ELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTRTP 334 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDP 466 + F + G C G L R++L + A+ + F L DP Sbjct: 335 VPHVAFGH---------GIHHCLGAALTRLQLRIAYTALWRRFPALQLADP 376 >3ABB-A nrPDB Length = 408 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 49/197 (24%), Positives = 77/197 (39%), Gaps = 30/197 (15%) Query: 287 DGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQE 346 D + + L AG ETT + G L L+++P E+ID ++ R P Sbjct: 231 DEVVMIALVLLVAGHETTVNAIALGALTLIQHP-------EQIDVLL---RDPG------ 274 Query: 347 MPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDP 406 + VV E+ RF T V ++ A D G I G V+ ++ + D + + +P Sbjct: 275 --AVSGVVEELLRF-TSVSDHIVRMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENP 331 Query: 407 EKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDP 466 + F + + + F G C G+ LAR EL + L + L P Sbjct: 332 DIFDAR---------RNARHHVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLAVP 382 Query: 467 KDIDLSPIHIGFGCIPP 483 +D PI G P Sbjct: 383 --LDEVPIKAGHDAQGP 397 >2RFC-A nrPDB Length = 343 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 48/179 (26%), Positives = 69/179 (38%), Gaps = 33/179 (18%) Query: 281 ERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPA 340 R TMD + L G ETT+ + + ++ + P+I ID A Sbjct: 170 NRKLTMDEKIKYIMLLIIGGNETTTNLIGNMIRVIDENPDI-------ID--------DA 214 Query: 341 IKDRQEMPYMDAVVHEIQRFITLVPSNLPHE-ATRDTIFRGYLIPKGTVVVPTLDSVLYD 399 +K+R V E R+ + + LPH A D+ I KG V+ L S D Sbjct: 215 LKNRS------GFVEETLRYYSPIQF-LPHRFAAEDSYINNKKIKKGDQVIVYLGSANRD 267 Query: 400 NQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 F +P+ FK + F G +C G LAR+E + L IL HF Sbjct: 268 ETFFDEPDLFK----------IGRREMHLAFGIGIHMCLGAPLARLEASIALNDILNHF 316 >6DCD-A nrPDB Length = 424 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 51/179 (28%), Positives = 74/179 (41%), Gaps = 34/179 (18%) Query: 287 DGITVTVAD-------LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIP 339 DG T V D LF AG ETT+ L + +L P+I+ +L E +R + P+ I Sbjct: 233 DGSTPEVIDVVRSATFLFAAGQETTAKLLTAAMRVLGDRPDIQRRLRE--NRSLIPNFI- 289 Query: 340 AIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYD 399 +E MD+ V R A + T G I GTVV+ + D Sbjct: 290 -----EESLRMDSPVKSDSRL-----------ARKRTTVGGLDIAAGTVVMVLPGAANRD 333 Query: 400 NQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 + F DP +F+ L+ ++ F+ G C G LAR+E + L IL Sbjct: 334 PRRFEDPHEFR----LDRPNVREH----MAFARGVHSCPGGPLARVEGRVSLERILDRM 384 >3A50-A nrPDB Length = 411 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 45/175 (25%), Positives = 68/175 (38%), Gaps = 33/175 (18%) Query: 272 EMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDR 331 +M+ ++ S E L M + L AG ETT + G+L L+ +P+ + L E+ Sbjct: 215 DMDGDRLSQEELVAMAML------LLIAGHETTVNLIGNGVLALLTHPDQRKLLAED--- 265 Query: 332 VIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVP 391 PS I + V E RF + V D + G IP G +V+ Sbjct: 266 ---PSLI------------SSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVML 310 Query: 392 TLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARME 446 L + D P+P++ + G F F G C G LAR+E Sbjct: 311 GLAAANRDADWMPEPDRLDITRDAS-GGVF--------FGHGIHFCLGAQLARLE 356 >4MM0-A nrPDB Length = 399 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 37/163 (22%), Positives = 64/163 (39%), Gaps = 27/163 (16%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG E S L +L L+++P DR+ R P + + + V Sbjct: 233 LLLAGYEPASNQLGSSVLTLLRFP----------DRLAELRRDPGL--------LPSAVE 274 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E+ R+ L D IP + V+ + + +D + F DP + + Sbjct: 275 ELMRYAPAGDGALFRVTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTGLRLDRPD 334 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 N++ + +F C G LAR+EL + + A+L+ F Sbjct: 335 NQHTALGHGIHF---------CLGAALARVELQVAIGALLRRF 368 >4TX3-A nrPDB Length = 404 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 39/171 (22%), Positives = 67/171 (39%), Gaps = 27/171 (15%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG + S + G+L L+++PE +I A+ R + D V Sbjct: 239 LMLAGDDNVSGMIGLGVLALLRHPE----------------QIAAL--RGDDQSADRAVD 280 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E+ R++T+ + P A D + +I +G V+ +L D PD ++ Sbjct: 281 ELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTRTP 340 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDP 466 + F + G C G L R++L + A+ + F L DP Sbjct: 341 VPHVAFGH---------GIHHCLGAALTRLQLRIAYTALWRRFPALQLADP 382 >3OFT-A nrPDB Length = 396 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 47/172 (27%), Positives = 70/172 (40%), Gaps = 31/172 (18%) Query: 282 RLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAI 341 R +T+D +L F G +T + + L L ++PE + L E P IPA Sbjct: 217 RPWTVDEARRMCRNLLFGGLDTVAAMIGMVALHLARHPEDQRLLRER------PDLIPAA 270 Query: 342 KDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLY--D 399 D ++R+ T+ S A D G I KG +V L SVL+ D Sbjct: 271 AD-----------ELMRRYPTVAVS---RNAVADVDADGVTIRKGDLVY--LPSVLHNLD 314 Query: 400 NQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLL 451 F PE+ + + L +++ G C G GLARME+ + L Sbjct: 315 PASFEAPEEVRFDRGL---APIRHTT----MGVGAHRCVGAGLARMEVIVFL 359 >6A7I-A nrPDB Length = 411 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 54/231 (23%), Positives = 90/231 (38%), Gaps = 45/231 (19%) Query: 260 NCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYP 319 N DLT L+ E H T + I T+ + AG ETT + + + L +P Sbjct: 206 NPGDDLTSALIAASENGDH-----LTDEEIVNTLQLIIAAGHETTISLIVNVVEALQTHP 260 Query: 320 EIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFR 379 E +K+ ++ IG D V+ E R+ T L AT D Sbjct: 261 EQRKKV---LNGEIG---------------WDGVIEETLRWNTPTSHVLIRFATEDIEVG 302 Query: 380 GYLIPKGTVVVPTLDSVLYDNQEF-PDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCA 438 ++PKG ++ + ++ D +++ P +F N + F + G VC Sbjct: 303 DKILPKGEGLIISFGALGRDEEQYGPTAGEFDATRTPNRHIAFGH---------GPHVCP 353 Query: 439 GEGLARMELFLLLCAILQHF------------NLKPLVDPKDIDLSPIHIG 477 G L+R+E + L A+ + F KP+V D+ P+ +G Sbjct: 354 GAALSRLEAGIALPALYERFPELDLAVPASDLRNKPIVTQNDLHELPVKLG 404 >5M0P-A nrPDB Length = 428 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 39/147 (26%), Positives = 62/147 (42%), Gaps = 19/147 (12%) Query: 342 KDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQ 401 K + E Y E++R+ VP LP +A D F+G IP G + + +D Sbjct: 276 KIKSEPDYAYKFAQEVRRYYPFVPF-LPGKAKVDIDFQGVTIPAGVGLALDVYGTTHDES 334 Query: 402 EFPDPEKFKPEHFLNENGK------FKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAIL 455 + DP +F+PE F +G DY+ T R CAGE + +++ + Sbjct: 335 LWDDPNEFRPERFETWDGSPFDLIPQGGGDYW----TNHR-CAGEWIT----VIIMEETM 385 Query: 456 QHFNLKPLVDPKDIDLSPIHIGFGCIP 482 ++F K D + DL + IP Sbjct: 386 KYFAEKITYDVPEQDL---EVDLNSIP 409 >6M7L-A nrPDB Length = 404 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 51/212 (24%), Positives = 88/212 (41%), Gaps = 34/212 (16%) Query: 263 RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE 322 RD D +L + ++ + + G+ V + + E T + L G L+L+++PE Sbjct: 211 RDPGDGMLGMVARDHGADISDEELAGLCAVVMN---SSVEQTESCLAAGTLLLLEHPE-- 265 Query: 323 EKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYL 382 + +++R E+ + V EI R++++ P AT D G + Sbjct: 266 --------------QFALLRERPELG--EQAVEEIVRYLSVFEGLDPRTATEDVEIGGQV 309 Query: 383 IPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGL 442 I KG V S+L N+ P + F + K S + F G C G L Sbjct: 310 IKKGEAV---FCSLLAANRADPALDGF--------DITRKESRHVA-FGHGIHHCLGAPL 357 Query: 443 ARMELFLLLCAILQHF-NLKPLVDPKDIDLSP 473 ARMEL + ++ F +L+ V ++I P Sbjct: 358 ARMELRIAFTTLVSRFPSLRTAVPAEEIRFRP 389 >3EJB-B nrPDB Length = 404 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 60/232 (25%), Positives = 91/232 (39%), Gaps = 44/232 (18%) Query: 235 VIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVA 294 ++ +A KE + +R K H Q +D+ LL EK+K + E + T Sbjct: 184 AVQAMAYFKELIQKR-KRHPQ-------QDMISMLLKGREKDKLTEEEAAS------TCI 229 Query: 295 DLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVV 354 L AG ETT + +L L+++PE KL E D +IG V Sbjct: 230 LLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPD-LIG-----------------TAV 271 Query: 355 HEIQRFITLVPSNLPHE-ATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEH 413 E R+ + P+ + A+ D G I +G V L + D F +P+ F Sbjct: 272 EECLRYES--PTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITR 329 Query: 414 FLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVD 465 N + F + G VC G LAR+E + + +LQ L D Sbjct: 330 SPNPHLSFGH---------GHHVCLGSSLARLEAQIAINTLLQRMPSLNLAD 372 >4UBS-A nrPDB Length = 393 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 42/173 (24%), Positives = 63/173 (36%), Gaps = 28/173 (16%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG ETT+ + G L+++PE +L R E M A V Sbjct: 229 LLIAGHETTANMISLGTFTLLRHPEQLAEL------------------RAEPGLMPAAVE 270 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E+ RF+++ L AT D G I VV + D F +P+ Sbjct: 271 ELLRFLSIA-DGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALD----- 324 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKD 468 + + + F G C G+ LAR E+ + L + + L P D Sbjct: 325 ----WHRSARHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLAAPAD 373 >5FYF-A nrPDB Length = 470 Score = 41.6 bits (96), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 45/175 (25%), Positives = 76/175 (43%), Gaps = 28/175 (16%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L G +TT ++ GL+ + ++P EKL + P IP + V Sbjct: 304 LIVGGNDTTRNSMSGGLVAMNEFPREFEKLKAK------PELIPNM------------VS 345 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 EI R+ T + + + A +D G I KG VV S D ++F +P++F + Sbjct: 346 EIIRWQTPL-AYMRRIAKQDVELGGQTIKKGDRVVMWYASGNRDERKFDNPDQFIIDR-- 402 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF-NLKPLVDPKDI 469 K + F G C G LA ++L +L IL+ F N++ + +P+ + Sbjct: 403 ------KDARNHMSFGYGVHRCMGNRLAELQLRILWEEILKRFDNIEVVEEPERV 451 >2ZBZ-A nrPDB Length = 412 Score = 41.6 bits (96), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 38/160 (23%), Positives = 61/160 (38%), Gaps = 27/160 (16%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG ETT++ ++ L+ +PE L DR +P V Sbjct: 241 LLIAGHETTASMTSLSVITLLDHPEQYAALR---------------ADRSLVP---GAVE 282 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E+ R++ + AT D G LI G V+ D + DP+ Sbjct: 283 ELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTVYEDPDALD----- 337 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAIL 455 + + + F G C G+ LAR+EL ++L A++ Sbjct: 338 ----IHRSARHHLAFGFGVHQCLGQNLARLELEVILNALM 373 >3AWQ-A nrPDB Length = 415 Score = 41.6 bits (96), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 22/70 (31%), Positives = 37/70 (52%), Gaps = 1/70 (1%) Query: 345 QEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFP 404 Q+ Y + V E++RF P+ + A++D + G P+G VV L +D + Sbjct: 269 QQPDYAELFVQEVRRFYPFFPAVVA-RASQDFEWEGMAFPEGRQVVLDLYGSNHDAATWA 327 Query: 405 DPEKFKPEHF 414 DP++F+PE F Sbjct: 328 DPQEFRPERF 337 >2WM5-A nrPDB Length = 435 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 55/212 (25%), Positives = 81/212 (38%), Gaps = 43/212 (20%) Query: 240 AEVKEYVS----ERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVAD 295 A++ Y + +R HH DLT L VE E + ERL + + + + Sbjct: 224 ADIGAYATALAEDRRVNHHD--------DLTSSL-VEAEVD---GERLSSREIASFFIL- 270 Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG ETT + +G+L L +YPE ++ + D + P+ V Sbjct: 271 LVVAGNETTRNAITHGVLALSRYPEQRDRWWSDFDG-LAPT----------------AVE 313 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 EI R+ + V + T+D RG + G V S D +F DP F Sbjct: 314 EIVRWASPV-VYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNP 372 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMEL 447 N + F G C G LAR E+ Sbjct: 373 NPHLGFG--------GGGAHFCLGANLARREI 396 >5IT1-A nrPDB Length = 399 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 45/175 (25%), Positives = 67/175 (38%), Gaps = 35/175 (20%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L A +TT+ + G +L+ P+ L ++ PS I V Sbjct: 234 LLIAAHDTTACMIGLGTALLLDRPDQLALLQKD------PSLI------------GNAVE 275 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKF----KP 411 E+ R++T+ AT+D G I KG VV L S +D DPE+F +P Sbjct: 276 ELLRYLTIGQFGAERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDITRRP 335 Query: 412 EHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDP 466 L F G C G+ LAR+EL ++ + + F L P Sbjct: 336 APHLA-------------FGFGAHQCIGQQLARIELQIVFGTLFRRFPTLRLAKP 377 >5CJE-A nrPDB Length = 393 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/183 (24%), Positives = 68/183 (37%), Gaps = 33/183 (18%) Query: 274 EKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI 333 + ++ S E L M I L AG ETT + G+ L+ +P+ L Sbjct: 214 DDDRLSGEELRAMAFI------LLVAGHETTVNLITNGVHTLLTHPDQLAAL-------- 259 Query: 334 GPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTL 393 R +M +D V E+ RF V + A G I +G V+ L Sbjct: 260 ----------RADMTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPVMIGL 309 Query: 394 DSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCA 453 D+ D PDP F + F + ++ C G LAR+E + L + Sbjct: 310 DAAGRDPARHPDPHVFDIHRAPQGHLAFGHGIHY---------CLGAPLARLEARVALRS 360 Query: 454 ILQ 456 +L+ Sbjct: 361 LLE 363 >5L94-A nrPDB Length = 410 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/184 (23%), Positives = 72/184 (39%), Gaps = 32/184 (17%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG ETT+ + + LM+ E+L ++E + + + Sbjct: 239 LLIAGNETTTNLISNTIYCLMEDKASFERL------------------KREKELLPSGIE 280 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E+ R+ + V + L D G + G VVP + S D + F DPE FK + Sbjct: 281 EVLRYRSPVQA-LHRIVKEDVTLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKID--- 336 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVD-PKDIDLSPI 474 + + F G C G LAR+E ++L ++ + P +D +L PI Sbjct: 337 ------RKPNVHMAFGRGIHFCLGAPLARIEAKIMLAELIDRY---PQMDWSPSFELKPI 387 Query: 475 HIGF 478 F Sbjct: 388 ESTF 391 >1LG9-A nrPDB Length = 398 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 42/171 (24%), Positives = 65/171 (38%), Gaps = 27/171 (15%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 + AG + S + G+L ++++PE +ID G D Q V Sbjct: 233 VMLAGDDNISGMIGLGVLAMLRHPE-------QIDAFRG--------DEQSAQR---AVD 274 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E+ R++T+ S P A D G I KG V+ +L + D PD ++ Sbjct: 275 ELIRYLTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLD----- 329 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDP 466 + F G C G LAR+EL + + + F L DP Sbjct: 330 ----VTREPIPHVAFGHGVHHCLGAALARLELRTVFTELWRRFPALRLADP 376 >6A7J-A nrPDB Length = 411 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 54/231 (23%), Positives = 89/231 (38%), Gaps = 45/231 (19%) Query: 260 NCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYP 319 N DLT L+ E H T + I T+ + AG ETT + + + L +P Sbjct: 206 NPGDDLTSALIAASEDGDH-----LTDEEILNTLQLIIAAGHETTISLIVNVVEALAIHP 260 Query: 320 EIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFR 379 E +K+ E+P+ + V+ E R+ T L AT D Sbjct: 261 EQRKKVLS-----------------GEIPW-EGVIEETLRWNTPTSHVLIRFATEDIEVG 302 Query: 380 GYLIPKGTVVVPTLDSVLYDNQEF-PDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCA 438 ++PKG +V + ++ D +++ P F N + F + G VC Sbjct: 303 DKVLPKGEGLVVSFGALGRDEEQYGPTAGDFDATRTPNRHIAFGH---------GPHVCP 353 Query: 439 GEGLARMELFLLLCAILQHF------------NLKPLVDPKDIDLSPIHIG 477 G L+R+E + L A+ + F KP+V D+ P+ +G Sbjct: 354 GAALSRLEAGIALPALYERFPELDLAVPAAELRNKPIVTQNDLHDLPVKLG 404 >2X9P-A nrPDB Length = 404 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 41/164 (25%), Positives = 64/164 (39%), Gaps = 28/164 (17%) Query: 285 TMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDR 344 T D + L FAG ++ ++ + G+++L +P+ R A+ D Sbjct: 227 TEDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPD---------------QRAAALADP 271 Query: 345 QEMPYMDAVVHEIQRFITLVPSNLPHE-ATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF 403 M V E+ R S LP A+ D F G I G +V+ L +D + F Sbjct: 272 D---VMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAF 328 Query: 404 PDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMEL 447 PE+F N + F + + C G LAR+EL Sbjct: 329 TGPEEFDAARTPNPHLTFGHGIWH---------CIGAPLARLEL 363 >5L1U-A nrPDB Length = 401 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 54/189 (28%), Positives = 73/189 (38%), Gaps = 42/189 (22%) Query: 267 DCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLH 326 D +L E+ EK A L D + A L F G ETT + G L+L++ P +L Sbjct: 206 DDILSELIAEKDGA--LSDADIAHLGNAVLLF-GYETTIVRIDLGTLLLLRNPVQRAQLA 262 Query: 327 EEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRF-ITLVPSN--LPHEATRDTIFRGYLI 383 E+ P PA V EI R + SN +P A D +I Sbjct: 263 ED------PGLAPA------------AVEEILRLGVGGKGSNALIPRYAHGDITVGETVI 304 Query: 384 PKGTVVVPTLDSVLYDNQEFPDPEKF-----KPEHFLNENGKFKYSDYFKPFSTGKRVCA 438 G V+ + + YD++ FPD F +P L F G R C Sbjct: 305 RTGDAVMLAIGAANYDDRAFPDGGLFDLTRVRPRSHL-------------AFGHGARHCI 351 Query: 439 GEGLARMEL 447 G LAR+EL Sbjct: 352 GRTLARIEL 360 >1Z8P-A nrPDB Length = 404 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 46/204 (22%), Positives = 81/204 (39%), Gaps = 29/204 (14%) Query: 267 DCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLH 326 D LL + + + + + D +T L AG E++ + + G +L+ +P+ + Sbjct: 209 DDLLSALIRVQDDDDGRLSADELTSIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVR 268 Query: 327 EEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKG 386 + PS +P V EI R+I P A + G IP+ Sbjct: 269 RD------PSALPN------------AVEEILRYIA-PPETTTRFAAEEVEIGGVAIPQY 309 Query: 387 TVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARME 446 + V+ + D ++FPDP +F + + + S F G C G LA++E Sbjct: 310 STVLVANGAANRDPKQFPDPHRFD----VTRDTRGHLS-----FGQGIHFCMGRPLAKLE 360 Query: 447 LFLLLCAILQHFNLKPL-VDPKDI 469 + L A+ F L +D D+ Sbjct: 361 GEVALRALFGRFPALSLGIDADDV 384 >5FOI-A nrPDB Length = 408 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 37/161 (22%), Positives = 63/161 (39%), Gaps = 28/161 (17%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG ET++ + +L L+++PE +L E+ P +P D Sbjct: 244 LLAAGHETSANQVTLSVLTLLRHPETAAELREQ------PELMPNAVD------------ 285 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E+ R+ + + L AT D + + I G ++ L S +D F F Sbjct: 286 ELLRYHS-IADGLRRAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHRPA 344 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQ 456 + F Y G C G+ LAR+E+ + L + + Sbjct: 345 RHHVAFGY---------GPHQCLGQNLARLEMEVTLGKLFR 376 >2WIO-A nrPDB Length = 431 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 44/164 (26%), Positives = 63/164 (38%), Gaps = 26/164 (15%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG TT+ L + L ++P + E+ P RIPAI V Sbjct: 258 LLLAGHITTTVLLGNIVRTLDEHPAHWDAAAED------PGRIPAI------------VE 299 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E+ R+ P + T+ T G IP +V + S D+ DP++F P Sbjct: 300 EVLRYRPPFP-QMQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSR-- 356 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFN 459 G + S F G C G LAR+E + L I+ F Sbjct: 357 KSGGAAQLS-----FGHGVHFCLGAPLARLENRVALEEIIARFG 395 >5HIW-A nrPDB Length = 398 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 53/208 (25%), Positives = 83/208 (39%), Gaps = 40/208 (19%) Query: 266 TDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKL 325 +D LL E+ + AE L ++ V L ETTS L L+ L+ +P+ +L Sbjct: 196 SDTLLGEIAR-AIVAEGLGGVEACEGVVLTLILGSYETTSWMLANLLVALLAHPDAMNQL 254 Query: 326 HEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPK 385 ++ PS +P + +E + I RF+ R+ G + Sbjct: 255 RQQ------PSLLP--QAIEESTRWCSSAAGIVRFVE-----------REATIGGETLAA 295 Query: 386 GTVVVPTLDSVLYDNQEFPDPEKF----KPEHFLNENGKFKYSDYFKPFSTGKRVCAGEG 441 GT++ +L + YD + +P PE F +P LN G Y C G Sbjct: 296 GTILYLSLIARHYDEEIYPRPETFDIHRRPVGMLNFGGGLHY-------------CVGAP 342 Query: 442 LARMELFLLLCAILQHF---NLKPLVDP 466 LARME + + +L+ F P V P Sbjct: 343 LARMEARVGVSLLLERFPALRADPTVQP 370 >4Z5Q-A nrPDB Length = 423 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 49/227 (21%), Positives = 95/227 (41%), Gaps = 37/227 (16%) Query: 231 SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGIT 290 + + +++ ++++Y + VKE PRD L+E + + +RL + I Sbjct: 204 TDEECVQSFMDLQKYFEDLVKERRAE-----PRDDLTSALIEA---RDAHDRLAEPELIG 255 Query: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350 + ++ + G ETT++ + + +L + E+ +L + P IPA Sbjct: 256 LCIS-ILIGGFETTASEISSFVHVLQQRRELWTRLCAD------PEAIPA---------- 298 Query: 351 DAVVHEIQRFITLVPSNL-PHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKF 409 V E+ RF+ + + P A D G L+ +G V+ +V D F + ++ Sbjct: 299 --AVEELLRFVPFAANGISPRYALEDMTVGGVLVREGEPVIVDTSAVNRDGLVFDNADEV 356 Query: 410 KPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQ 456 + N + F + G C G LAR+EL L A+++ Sbjct: 357 VIDRADNRHMVFGH---------GAHHCLGAHLARVELQEALKALVE 394 >4YT3-A nrPDB Length = 410 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 59/228 (25%), Positives = 87/228 (38%), Gaps = 44/228 (19%) Query: 241 EVKEYVSERVKEHHQSLDPNC------PRD--LTDCLLVEMEKEKHSAERLYTMDGITVT 292 EV + KE++Q L P P D ++D L E++ E ++T D + T Sbjct: 183 EVDKLKQVAAKEYYQYLYPIVVQKRLNPADDIISDLLKSEVDGE------MFTDDEVVRT 236 Query: 293 VADLFFAGTETTSTTLRYGLL-ILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMD 351 + AG ETTS L +L E+ ++LHE +D V Sbjct: 237 TMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDLV------------------P 278 Query: 352 AVVHEIQRF-ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410 V E+ RF L+ L D G + +G VV + + D + F DP Sbjct: 279 QAVEEMLRFRFNLI--KLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTL- 335 Query: 411 PEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 + N K + F G C G LAR+E + L A L+ F Sbjct: 336 --NIHRPNNKKHLT-----FGNGPHFCLGAPLARLEAKIALTAFLKKF 376 >5GWE-A nrPDB Length = 405 Score = 37.7 bits (86), Expect = 0.011, Method: Compositional matrix adjust. Identities = 52/215 (24%), Positives = 79/215 (36%), Gaps = 38/215 (17%) Query: 238 NVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHS-AERLYTMDGITVTVADL 296 N+ E + V + H N DL E H A LY+ L Sbjct: 190 NLVEYWQECQRMVADAHAHGGDNLTADLVRAQQEGQEITDHEIASLLYS----------L 239 Query: 297 FFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHE 356 FAG ETT+T + +L+ +PE + + E P IPA D + + Y ++V Sbjct: 240 LFAGHETTTTLISNCFRVLLDHPEQWQAILE------NPKLIPAAVD-EVLRYSGSIV-- 290 Query: 357 IQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLN 416 +A +DT G I +G V+ + S D F + E+F Sbjct: 291 ----------GWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFD---ISR 337 Query: 417 ENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLL 451 N + S F G C G LA+++ + L Sbjct: 338 ANAREHLS-----FGFGIHYCLGNMLAKLQAKICL 367 >2IAG-A nrPDB Length = 482 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 31/103 (30%), Positives = 46/103 (44%), Gaps = 14/103 (13%) Query: 399 DNQEFPDPEKFKPEHFLNENGKFK---YSD------YFKPFSTGKRVCAGEGLARMELFL 449 D + + DPE FK FLN +G K Y D Y P+ G C G A + Sbjct: 372 DPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQ 431 Query: 450 LLCAILQHFNLKPL---VDPKDIDLSPIHIGFGCIPPRYKLCV 489 + +L H +L+ + V+ + DLS GFG + P + + V Sbjct: 432 FVFLVLVHLDLELINADVEIPEFDLS--RYGFGLMQPEHDVPV 472 >3RWL-A nrPDB Length = 426 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 46/180 (25%), Positives = 75/180 (41%), Gaps = 38/180 (21%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L G +TT ++ G+L L K P+ KL PA+ ++ +V Sbjct: 262 LIVGGNDTTRNSMTGGVLALHKNPDQFAKLKAN----------PAL--------VETMVP 303 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKF-----K 410 EI R+ T + +++ A D+ G I KG VV S D++ PE+F + Sbjct: 304 EIIRWQTPL-AHMRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDRPR 362 Query: 411 PEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFN-LKPLVDPKDI 469 P L+ F G C G LA M+L +L IL F+ ++ + +P+ + Sbjct: 363 PRQHLS-------------FGFGIHRCVGNRLAEMQLRILWEEILTRFSRIEVMAEPERV 409 >6GII-A nrPDB Length = 479 Score = 37.7 bits (86), Expect = 0.013, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 37/79 (46%), Gaps = 8/79 (10%) Query: 373 TRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFST 432 TR+ G +P G ++ + S +D+ F DPE F + G+ S++ F Sbjct: 363 TREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFF-------DIGRSNASEHLN-FGY 414 Query: 433 GKRVCAGEGLARMELFLLL 451 G C G L RME+ +++ Sbjct: 415 GAHQCLGRNLGRMEMQIMI 433 >5XJN-A nrPDB Length = 455 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 52/215 (24%), Positives = 79/215 (36%), Gaps = 38/215 (17%) Query: 238 NVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHS-AERLYTMDGITVTVADL 296 N+ E + V + H N DL E H A LY+ L Sbjct: 240 NLVEYWQECQRMVADAHAHGGDNLTADLVRAQQEGQEITDHEIASLLYS----------L 289 Query: 297 FFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHE 356 FAG ETT+T + +L+ +PE + + E P IPA D + + Y ++V Sbjct: 290 LFAGHETTTTLISNCFRVLLDHPEQWQAILE------NPKLIPAAVD-EVLRYSGSIV-- 340 Query: 357 IQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLN 416 +A +DT G I +G V+ + S D F + E+F Sbjct: 341 ----------GWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFD---ISR 387 Query: 417 ENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLL 451 N + S F G C G LA+++ + L Sbjct: 388 ANAREHLS-----FGFGIHYCLGNMLAKLQAKICL 417 >1UE8-A nrPDB Length = 367 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 26/93 (27%), Positives = 42/93 (45%), Gaps = 9/93 (9%) Query: 378 FRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVC 437 R +I +G +V + S D + F DP+ F P+ N + F +G +C Sbjct: 267 IRDQVIDEGELVRVWIASANRDEEVFKDPDSFIPDRTPNPH---------LSFGSGIHLC 317 Query: 438 AGEGLARMELFLLLCAILQHFNLKPLVDPKDID 470 G LAR+E + L + F +K +V + ID Sbjct: 318 LGAPLARLEARIALEEFAKKFRVKEIVKKEKID 350 >4JBT-A nrPDB Length = 410 Score = 37.0 bits (84), Expect = 0.019, Method: Compositional matrix adjust. Identities = 67/277 (24%), Positives = 106/277 (38%), Gaps = 53/277 (19%) Query: 216 QLYNNFPSFLHYL-PGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEME 274 QL + +F L P R ++ + E+ Y +E V+ ++ +P DLT L+ + Sbjct: 171 QLLTWYKAFFSILTPQDER--LRVIDEMHGYFTEMVRR--KTAEPG--DDLTSALIYATD 224 Query: 275 KEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIG 334 E E + + + L AG ETT + + + L+ +PE +L D IG Sbjct: 225 GETPLTE-----EEVIGNLQALVAAGHETTVSLILTAVRALLSHPE---QLRLVRDGEIG 276 Query: 335 PSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLD 394 R + P V+H + RF AT D +IP+G VV + Sbjct: 277 WETAIEETLRWDGP----VIHLLMRF-----------ATEDIDLGDAVIPRGEGVVMSYR 321 Query: 395 SVLYD-NQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCA 453 ++ D D + F S F G +C G LAR+E + L A Sbjct: 322 AIGRDITVHGADADDFD---ITRATAARHIS-----FGHGPHICPGAALARLEAAIALPA 373 Query: 454 ILQHF-------------NLKPLVDPKDIDLSPIHIG 477 + F NL P++ D+ PIH+G Sbjct: 374 LFTRFPHLHPALPLDQIPNL-PVLTQNDLSHFPIHLG 409 >3P3Z-A nrPDB Length = 416 Score = 37.0 bits (84), Expect = 0.021, Method: Compositional matrix adjust. Identities = 40/167 (23%), Positives = 58/167 (34%), Gaps = 26/167 (15%) Query: 293 VADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDA 352 VA + AG ETT+ L + ++P+ K+ E P P Sbjct: 247 VATVLVAGYETTNHQLALAMYDFAQHPDQWMKIKE------NPELAPQ------------ 288 Query: 353 VVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPE 412 V E+ R+ +P A D G IP GT V D + F D ++F Sbjct: 289 AVEEVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADADRF--- 345 Query: 413 HFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFN 459 + K F G C G LAR+EL + A+ + Sbjct: 346 -----DITVKREAPSIAFGGGPHFCLGTALARLELTEAVAALATRLD 387 >6G71-A nrPDB Length = 405 Score = 36.6 bits (83), Expect = 0.023, Method: Compositional matrix adjust. Identities = 26/96 (27%), Positives = 41/96 (42%), Gaps = 10/96 (10%) Query: 352 AVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKP 411 AV E R++ + +P + DT GY IP+G + + S D + DP++F Sbjct: 271 AVFEESIRWVAPI-GMVPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRFDI 329 Query: 412 EHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMEL 447 E + S+ F G VC G AR ++ Sbjct: 330 E---------RGSEAHLAFGKGVHVCLGAWAARSQV 356 >1GWI-A nrPDB Length = 411 Score = 36.6 bits (83), Expect = 0.024, Method: Compositional matrix adjust. Identities = 63/284 (22%), Positives = 100/284 (35%), Gaps = 60/284 (21%) Query: 176 PCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKV 235 P V+AD++ + + RL LF + F + P +V Sbjct: 152 PMYVVADLM-----GIEEARLPRLKVLFEKFFSTQTPP-------------------EEV 187 Query: 236 IKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVAD 295 + + E+ +++ V + P DLT L+ E H T I T+ Sbjct: 188 VATLTELASIMTDTVAAKRAA--PG--DDLTSALIQASENGDH-----LTDAEIVSTLQL 238 Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 + AG ETT + + ++ L +PE R + E AVV Sbjct: 239 MVAAGHETTISLIVNAVVNLSTHPE---------------QRALVLSGEAEW---SAVVE 280 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF-PDPEKFKPEHF 414 E RF T L A D +IP G ++ + ++ D + P ++F Sbjct: 281 ETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADRFD---L 337 Query: 415 LNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 +G S F G VC G L+RME + L A+ F Sbjct: 338 TRTSGNRHIS-----FGHGPHVCPGAALSRMEAGVALPALYARF 376 >4Z5P-A nrPDB Length = 400 Score = 36.2 bits (82), Expect = 0.032, Method: Compositional matrix adjust. Identities = 54/239 (22%), Positives = 90/239 (37%), Gaps = 37/239 (15%) Query: 231 SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGIT 290 S + + A ++ Y+++ V + P+ D LL + + +RL + IT Sbjct: 178 SKEEAVSADASIRAYLADLVSARRAA--PH------DDLLGVLVSARDDDDRLTEDELIT 229 Query: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350 V L AG ET++ L + L+ + + L E+ P +P Sbjct: 230 FGVT-LLVAGHETSAHQLGNMVYALLTHEDQLSLLREQ------PELLPR---------- 272 Query: 351 DAVVHEIQRFITLVPS-NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKF 409 V E+ RF+ L A D G + G VV + D + F DP++ Sbjct: 273 --AVEELLRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRL 330 Query: 410 KPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKD 468 N + F + ++ C G LARMEL + + +L+ F L P D Sbjct: 331 DITREKNPHLAFGHGAHY---------CLGAQLARMELRVAIGGLLERFPGLRLAVPAD 380 >3ABA-A nrPDB Length = 403 Score = 36.2 bits (82), Expect = 0.032, Method: Compositional matrix adjust. Identities = 40/159 (25%), Positives = 62/159 (38%), Gaps = 35/159 (22%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L A +TT+ + G +L+ P+ L E+ PS + V Sbjct: 234 LLIAAHDTTACMIGLGTALLLDSPDQLALLRED------PS------------LVGNAVE 275 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKF----KP 411 E+ R++T+ ATRD G I KG VV + + +D +PE+F +P Sbjct: 276 ELLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITRRP 335 Query: 412 EHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLL 450 L F G C G+ LAR+EL ++ Sbjct: 336 APHLA-------------FGFGAHQCIGQQLARIELQIV 361 >5HDI-A nrPDB Length = 404 Score = 36.2 bits (82), Expect = 0.035, Method: Compositional matrix adjust. Identities = 47/204 (23%), Positives = 78/204 (38%), Gaps = 33/204 (16%) Query: 264 DLTDCLLVEMEKEKHSAERLYTMDGIT--VTVADLFFAGTETTSTTLRYGLLILMKYPEI 321 D D LL E+ S E +D +T V + LF AG E+T+ L + IL P+I Sbjct: 211 DPRDNLLGELATACASGE----LDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDI 266 Query: 322 EEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGY 381 ++++ R + A + E R+ + H T G Sbjct: 267 QQQV------------------RANPELLGAFIEETLRYEPPFRGHYRH-VRNATTLDGT 307 Query: 382 LIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEG 441 +P + ++ + D +F P +F+ + GK S F G C G Sbjct: 308 ELPADSHLLLLWGAANRDPAQFEAPGEFRLDR---AGGKGHIS-----FGKGAHFCVGAA 359 Query: 442 LARMELFLLLCAILQHFNLKPLVD 465 LAR+E ++L +L ++ D Sbjct: 360 LARLEARIVLRLLLDRTSVIEAAD 383 >4PWV-A nrPDB Length = 446 Score = 35.8 bits (81), Expect = 0.044, Method: Compositional matrix adjust. Identities = 40/171 (23%), Positives = 63/171 (36%), Gaps = 30/171 (17%) Query: 285 TMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDR 344 T + I + L G ET+ ++ + +YP+ E L R Sbjct: 256 TEEVIVLNCYSLILGGDETSRLSMIDSVQTFTQYPDQWELL------------------R 297 Query: 345 QEMPYMDAVVHEIQRFITLVPS-NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF 403 +++ E+ R+ T P+ + A D G +I G VV +S D + F Sbjct: 298 DGKVTLESATEEVLRWAT--PAMHFGRRAVTDMELHGQVIAAGDVVTLWNNSANRDEEVF 355 Query: 404 PDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAI 454 DP F N++ F Y +F C G L R E+ LL A+ Sbjct: 356 ADPYAFDLNRSPNKHITFGYGPHF---------CLGAYLGRAEVHALLDAL 397 >5KYO-A nrPDB Length = 430 Score = 35.4 bits (80), Expect = 0.056, Method: Compositional matrix adjust. Identities = 28/101 (27%), Positives = 44/101 (43%), Gaps = 12/101 (11%) Query: 351 DAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410 DA++ +RF + + E RD F G L+ G +V+ V D+ DP +F+ Sbjct: 305 DALLEFFRRFPVVSSAR---EVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDPLEFR 361 Query: 411 PEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLL 451 L + + F G C G LARME+ ++L Sbjct: 362 ----LGRKARQHST-----FGKGSHTCPGAHLARMEMKVVL 393 >3NC3-A nrPDB Length = 441 Score = 35.0 bits (79), Expect = 0.074, Method: Compositional matrix adjust. Identities = 37/168 (22%), Positives = 65/168 (38%), Gaps = 20/168 (11%) Query: 289 ITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMP 348 I + ++ A TE TL + L+ PE +++ V+ DR +P Sbjct: 259 ILALILNVLLAATEPADKTLALMIYHLLNNPE-------QMNDVLA--------DRSLVP 303 Query: 349 YMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEK 408 A + + L+P L ++DT+ G I K T+V + + D + F P+ Sbjct: 304 RAIAETLRYKPPVQLIPRQL----SQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDV 359 Query: 409 FK-PEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAIL 455 F L F + F +G C G A+ E+ ++ +L Sbjct: 360 FNIHREDLGIKSAFSGAARHLAFGSGIHNCVGTAFAKNEIEIVANIVL 407 >6FYJ-A nrPDB Length = 421 Score = 35.0 bits (79), Expect = 0.074, Method: Compositional matrix adjust. Identities = 36/134 (26%), Positives = 54/134 (40%), Gaps = 29/134 (21%) Query: 313 LILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEA 372 L L YPE +EKL + Y V E++RF P + Sbjct: 260 LALHHYPEEKEKLKS-----------------GDKKYSQMFVQEVRRFYPFFPFVVAL-V 301 Query: 373 TRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK-FKY-----SDY 426 +D ++GY +GT+ + L +D + + +P+ F P+ F G F + DY Sbjct: 302 KKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRFAKWEGSPFSFIPQGGGDY 361 Query: 427 FKPFSTGKRVCAGE 440 F G R CAGE Sbjct: 362 F----MGHR-CAGE 370 >3R9C-A nrPDB Length = 418 Score = 35.0 bits (79), Expect = 0.083, Method: Compositional matrix adjust. Identities = 40/174 (22%), Positives = 63/174 (36%), Gaps = 28/174 (16%) Query: 285 TMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDR 344 T D I T L AG ETT + L +++ P L + R Sbjct: 242 TEDEIIATCNLLLIAGHETTVNLIANAALAMLRTPGQWAALAADGSRA------------ 289 Query: 345 QEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFP 404 AV+ E R+ V + A D + +PKG ++ L + D Sbjct: 290 ------SAVIEETMRYDPPV-QLVSRYAGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVG 342 Query: 405 DPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 P++F P+ + ++ + K G C G LAR+E + L A+ F Sbjct: 343 APDRFDPDR-----AQIRHLGFGK----GAHFCLGAPLARLEATVALPALAARF 387 >5XW2-A nrPDB Length = 419 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 40/163 (24%), Positives = 62/163 (38%), Gaps = 28/163 (17%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG TT+ + +L L YPE ++ DR +P ++ Sbjct: 253 LLIAGYLTTTMLIGNTVLCLDSYPEQAARVR---------------ADRSLIP---GLLE 294 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E RF++ V + TRD G + +V+ + D ++F +PE F Sbjct: 295 ESMRFLSPVAATY-RATTRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPELFDMTRGP 353 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 N + F +F C G LARME + L +L F Sbjct: 354 NPHLGFGRGIHF---------CLGGPLARMEGRVALDHLLDRF 387 >5XNT-A nrPDB Length = 411 Score = 33.9 bits (76), Expect = 0.15, Method: Compositional matrix adjust. Identities = 57/228 (25%), Positives = 87/228 (38%), Gaps = 44/228 (19%) Query: 241 EVKEYVSERVKEHHQSLDPNC------PRD--LTDCLLVEMEKEKHSAERLYTMDGITVT 292 EV E KE++Q L P P D ++D L E++ E ++T D + T Sbjct: 183 EVNELKQVAAKEYYQYLYPIVVQKRLNPADDIISDLLKAEVDGE------MFTDDEVVRT 236 Query: 293 VADLFFAGTETTSTTLRYGLL-ILMKYPEIEEKLHEEIDRVIGPSRIPA-IKDRQEMPYM 350 + AG ETTS L +L E+ ++LHE +D V P + ++ R + + Sbjct: 237 TMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDLV--PQAVEEMLRYRFNLIKL 294 Query: 351 DAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410 D V E D G + +G VV + + D + F D Sbjct: 295 DRTVKE------------------DNDLLGVELKEGENVVVWMSAANLDEEMFEDAFTL- 335 Query: 411 PEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 + N K + F G C G LAR+E + L L+ F Sbjct: 336 --NIHRPNNKKHLT-----FGNGPHFCLGAPLARLEAKIALTTFLKKF 376 >2QBO-A nrPDB Length = 421 Score = 33.5 bits (75), Expect = 0.20, Method: Compositional matrix adjust. Identities = 44/171 (25%), Positives = 63/171 (36%), Gaps = 31/171 (18%) Query: 282 RLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAI 341 R T D L G +T L + + L K PE ++L E P RIPA Sbjct: 232 RPITSDEAKRMCGLLLVVGLDTVVNFLSFSMEFLAKSPEHRQELIER------PERIPA- 284 Query: 342 KDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKG-TVVVPTLDSVLYDN 400 E+ R +LV T D F G + KG +++P + S L + Sbjct: 285 -----------ACEELLRRFSLVADG--RILTSDYEFHGVQLKKGDQILLPQMLSGLDER 331 Query: 401 QEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLL 451 E P H K ++ F G +C G+ LAR E+ + L Sbjct: 332 ------ENACPMHVDFSRQKVSHTT----FGHGSHLCLGQHLARREIIVTL 372 >5YHJ-A nrPDB Length = 413 Score = 33.5 bits (75), Expect = 0.23, Method: Compositional matrix adjust. Identities = 37/150 (24%), Positives = 65/150 (43%), Gaps = 18/150 (12%) Query: 332 VIGPSRIPAIKDRQEMPYMDAV--VHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVV 389 V+ + P +K++ E + V E++RF P T D + GY P+GT+ Sbjct: 252 VLALHQFPDVKEQVERGEVSKTEFVQEVRRFYPFFPVAAARVKT-DFEWDGYAFPEGTLT 310 Query: 390 VPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY-FKPFSTGK----RVCAGEGLAR 444 + L +D + +P++F P F + +K S + F P G CAGE + Sbjct: 311 LLDLYGTNHDVSIWTEPDRFDPSRFKD----WKESPFNFIPQGGGDVDFGHRCAGEHVT- 365 Query: 445 MELFLLLCAILQHFNLK--PLVDPKDIDLS 472 +L +++ F + V P+D+ S Sbjct: 366 ---IAILAQVIELFTKEYAYTVPPQDLSYS 392 >6HQW-A nrPDB Length = 445 Score = 33.1 bits (74), Expect = 0.28, Method: Compositional matrix adjust. Identities = 41/156 (26%), Positives = 61/156 (39%), Gaps = 27/156 (17%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L G +TT T+ + L K+P+ E L + S IP V Sbjct: 280 LIVGGNDTTRNTMSGIVHALDKFPDQRELLERDA------SLIP------------NAVQ 321 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E R++T + +++ AT DT G I G V+ S D F +P+K + Sbjct: 322 ECIRYVTPL-AHMRRTATADTELFGNQIKAGEKVILWYISANRDETVFENPDKLMVD--- 377 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLL 451 N + S F G C G LA ++L +LL Sbjct: 378 RPNARRHLS-----FGHGIHRCVGARLAELQLRILL 408 >6BLD-A nrPDB Length = 419 Score = 33.1 bits (74), Expect = 0.30, Method: Compositional matrix adjust. Identities = 32/114 (28%), Positives = 43/114 (37%), Gaps = 18/114 (15%) Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG +TT T+ +GL L +P + L + D IG + V Sbjct: 257 LAVAGNDTTRQTISHGLKALTDFPSQKAWLLADFDTRIGTA-----------------VE 299 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKF 409 E+ R+ T V A D G LI G VV S +D F PE+ Sbjct: 300 ELVRWATPV-MTFRRTAAADFELGGQLIRAGEKVVMFYASGNWDEDAFCHPERL 352 >1GCW-B nrPDB Length = 135 Score = 32.3 bits (72), Expect = 0.52, Method: Composition-based stats. Identities = 21/69 (30%), Positives = 35/69 (50%), Gaps = 8/69 (11%) Query: 213 PWLQLY----NNFPSFLH--YLPGSHRKVIKNVAEVKEYVSERVKEHHQSL--DPNCPRD 264 PW Y +F S +H + G+ + +K++ +VK + K+H L DP Sbjct: 36 PWTNRYFQKRTDFRSSIHAGIVVGALQDAVKHMDDVKTLFKDLSKKHADDLHVDPGSFHL 95 Query: 265 LTDCLLVEM 273 LTDC++VE+ Sbjct: 96 LTDCIIVEL 104 >6AGB-C nrPDB Length = 195 Score = 31.6 bits (70), Expect = 0.76, Method: Compositional matrix adjust. Identities = 35/155 (22%), Positives = 67/155 (43%), Gaps = 36/155 (23%) Query: 202 LFNENFHLLST---PWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLD 258 + N+ H+ S PW +LY +F + YL G+H N V +V + D Sbjct: 51 IINKLIHIQSKENYPW-ELYTDFNEIVQYLSGAH----GNSDPVCLFVCNK--------D 97 Query: 259 PNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKY 318 P+ P LV +++ L M +TV + L + +T + +YG+L+L Sbjct: 98 PDVP-------LVLLQQ----IPLLCYMAPMTVKLVQLPKSAMDTFKSVSKYGMLLLRCD 146 Query: 319 PEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAV 353 +++K +I + + D + P+++A+ Sbjct: 147 DRVDKKFVSQIQKNV---------DLLQFPWLNAI 172 >2FR7-A nrPDB Length = 412 Score = 31.6 bits (70), Expect = 0.79, Method: Compositional matrix adjust. Identities = 39/176 (22%), Positives = 70/176 (39%), Gaps = 32/176 (18%) Query: 293 VADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDA 352 V L AG +TT + + L ++P+ +L + P++ + +A Sbjct: 245 VRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRAD----------PSLARNA---FEEA 291 Query: 353 VVHE--IQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410 V E +Q F TRD G I +G V+ L S D + + DP+++ Sbjct: 292 VRFESPVQTFF--------RTTTRDVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRYD 343 Query: 411 PEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDP 466 K S + F +G +C G+ +AR+E ++L A+ + + P Sbjct: 344 ITR--------KTSGHVG-FGSGVHMCVGQLVARLEGEVVLAALARKVAAIEIAGP 390 >1NLM-A nrPDB Length = 364 Score = 31.6 bits (70), Expect = 0.91, Method: Compositional matrix adjust. Identities = 17/44 (38%), Positives = 24/44 (54%), Gaps = 1/44 (2%) Query: 34 PGPFP-LPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQR 76 PG FP ++GN + ++ +P RLA R GPV L VG + Sbjct: 150 PGAFPNAEVVGNPVRTDVLALPLPQQRLAGREGPVRVLVVGGSQ 193 >5Y58-A nrPDB Length = 575 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 14/33 (42%), Positives = 18/33 (54%) Query: 203 FNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKV 235 +NE F+L P+L FPS L Y GS K+ Sbjct: 413 YNEGFYLYRVPFLDEIRKFPSLLSYDDGSEHKL 445 >4DO1-A nrPDB Length = 410 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 45/222 (20%), Positives = 82/222 (36%), Gaps = 40/222 (18%) Query: 241 EVKEYVSERVKEHHQSLDPNC------PRDLTDCLLVEMEKEKHSAERLYTMDGITVTVA 294 E+++ ER H ++ C P C+ + + T D + V Sbjct: 191 ELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGE------ITPDEAPLLVR 244 Query: 295 DLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVV 354 L AG +TT + + L ++P ++L R + Sbjct: 245 SLLSAGLDTTVNGIGAAVYCLARFPGELQRL------------------RSDPTLARNAF 286 Query: 355 HEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHF 414 E RF + V + TR+ G +I +G V+ L S D + + DP+ + Sbjct: 287 EEAVRFESPVQTFF-RTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITR- 344 Query: 415 LNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQ 456 K S + F +G +C G+ +AR+E ++L A+ + Sbjct: 345 -------KTSGHVG-FGSGVHMCVGQLVARLEGEVMLSALAR 378 >3OO3-A nrPDB Length = 384 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 51/230 (22%), Positives = 92/230 (40%), Gaps = 19/230 (8%) Query: 246 VSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDG-ITVTVADLFFAGTETT 304 +S ++E +S P R L+ +V K S +R DG I V V + ++ Sbjct: 157 LSRMIRESRESRLPRQ-RTLSGLGIVNYTKRLTSGKRRDPGDGMIGVIVREHGAEISDEE 215 Query: 305 STTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLV 364 L G LI+ + + V P ++ ++++ E+ +D+ E+ R ++V Sbjct: 216 LAGLAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLREKPEL--IDSATEEVLRHASIV 273 Query: 365 PSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYS 424 + P A D G I G V+ ++ + + D + K H Sbjct: 274 EAPAPRVALADVRMAGRDIHAGDVLTCSMLATNRAPGDRFDITREKATHMA--------- 324 Query: 425 DYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF-NLKPLVDPKDIDLSP 473 F G C G LAR++L + L A++ F +L+ V +D+ P Sbjct: 325 -----FGHGIHHCIGAPLARLQLRVALPAVVGRFPSLRLAVPEEDLRFKP 369 >5OFQ-A nrPDB Length = 409 Score = 29.6 bits (65), Expect = 2.9, Method: Compositional matrix adjust. Identities = 54/244 (22%), Positives = 91/244 (37%), Gaps = 47/244 (19%) Query: 245 YVSERVKEHHQSLDPNCPRDLTDCLL-VEMEKEKHSAERLYTMDGITVTVADLFFAGTET 303 Y E + E Q N DL LL E++ E + E + G + L AG ET Sbjct: 196 YFKEIIAERQQ----NKQEDLISLLLEAEIDGEHLTEEEVL---GFCIL---LLVAGNET 245 Query: 304 TSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITL 363 T+ + G+ + + +++ ++ +I S +P + V E R+ Sbjct: 246 TTNLITNGVRYMTEDVDVQNEVRRDI------SLVPNL------------VEETLRYYPP 287 Query: 364 VPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKY 423 + + + A D I +G V+ S D+ +F P+ F N + F + Sbjct: 288 IQA-IGRIAAEDVELGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHRKTNPHVSFGF 346 Query: 424 SDYFKPFSTGKRVCAGEGLARMELFLLLCAIL--------QHFNLKPLVDPKDIDLSPIH 475 +F C G LARME + +L Q+ +LKP+ P + Sbjct: 347 GIHF---------CLGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPIDSPFVFGVKKYE 397 Query: 476 IGFG 479 I F Sbjct: 398 IAFN 401 >3P5P-A nrPDB Length = 764 Score = 29.6 bits (65), Expect = 3.0, Method: Compositional matrix adjust. Identities = 22/90 (24%), Positives = 38/90 (42%), Gaps = 9/90 (10%) Query: 76 RMVVMHGYKAVKEALLDYKDE----FSGRGDL-----PAFHAHRDRGIIFNNGPTWKDIR 126 R + MHGY + L ++KDE FS G + R + F + D R Sbjct: 304 RTLRMHGYNVSSDVLNNFKDENGRFFSSAGQTHVELRSVVNLFRASDLAFPDERAMDDAR 363 Query: 127 RFSLTTLRNYGMGKQGNESRIQREAHFLLE 156 +F+ LR K +++ +E +++E Sbjct: 364 KFAEPYLREALATKISTNTKLFKEIEYVVE 393 >1GKQ-A nrPDB Length = 458 Score = 29.6 bits (65), Expect = 3.1, Method: Compositional matrix adjust. Identities = 27/92 (29%), Positives = 41/92 (44%), Gaps = 12/92 (13%) Query: 335 PSRIPAIKDRQEMPYMDAVVH---EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVP 391 P+ IPAI+DR + Y V +I RF+ +T+ G KGT+ V Sbjct: 334 PNGIPAIEDRVNLLYTYGVSRGRLDIHRFVDAA-------STKAAKLFGLFPRKGTIAVG 386 Query: 392 T-LDSVLYDNQEFPDPEKFKPEHFLNENGKFK 422 + D V+YD Q + K +H N+ F+ Sbjct: 387 SDADLVVYDPQ-YRGTISVKTQHVNNDYNGFE 417 >2WTB-A nrPDB Length = 725 Score = 29.6 bits (65), Expect = 3.5, Method: Compositional matrix adjust. Identities = 25/104 (24%), Positives = 50/104 (48%), Gaps = 13/104 (12%) Query: 313 LILMKYPEIEEKLHEEIDRVIGPSRIPA-IKDRQEMPYMDAVVHEIQRFITLVPSNLPHE 371 LIL YP I ++++E+ G R+ A ++ R M + ++ ++L+ +L +E Sbjct: 331 LILSNYPVILKEVNEKFLEA-GIGRVKANLQSRVRKGSMSQ--EKFEKTMSLLKGSLDYE 387 Query: 372 ATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 + RD V+ ++++ Q F D EK+ P+H + Sbjct: 388 SFRDV---------DMVIEAVIENISLKQQIFADLEKYCPQHCI 422 >1ODO-A nrPDB Length = 408 Score = 29.3 bits (64), Expect = 4.3, Method: Compositional matrix adjust. Identities = 44/214 (20%), Positives = 85/214 (39%), Gaps = 28/214 (13%) Query: 261 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 320 P D LL+ ++ +RL + + + T+ + AG ETT Sbjct: 205 TPGDDMTSLLIAARDDEGDGDRL-SPEELRDTLLLMISAGYETTVNV------------- 250 Query: 321 IEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRG 380 I++ +H + R P ++ ++ + E+ + D V ++ + L + T + G Sbjct: 251 IDQAVHTLLTR---PDQLALVR-KGEVTWADVVEETLRHEPAVKHLPLRYAVTDIALPDG 306 Query: 381 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 440 I +G ++ + + D + F + E+ F + +F C G Sbjct: 307 RTIARGEPILASYAAANRHPDWHEDADTFDATRTVKEHLAFGHGVHF---------CLGA 357 Query: 441 GLARMELFLLLCAILQHFNLKPLVDPKDIDLSPI 474 LARME+ L L ++ F L DP + +L P+ Sbjct: 358 PLARMEVTLALESLFGRFPDLRLADPAE-ELPPV 390 >2NZA-A nrPDB Length = 413 Score = 28.9 bits (63), Expect = 5.2, Method: Compositional matrix adjust. Identities = 27/107 (25%), Positives = 43/107 (40%), Gaps = 10/107 (9%) Query: 353 VVHEIQRFITLVPS-NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKP 411 + E+ R+I+ S L A D G I G V + + D FPDP++ Sbjct: 280 ALDELLRWISHRTSVGLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDL 339 Query: 412 EHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 + N + + +F C G LARM+ LL+ +L+ Sbjct: 340 DRDPNPHLAYGNGHHF---------CTGAVLARMQTELLVDTLLERL 377 >3NV6-A nrPDB Length = 452 Score = 28.5 bits (62), Expect = 7.4, Method: Compositional matrix adjust. Identities = 21/84 (25%), Positives = 39/84 (46%), Gaps = 9/84 (10%) Query: 373 TRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFST 432 +D ++G + +G +++ L + L+ + +PE +K + + S F Sbjct: 344 AKDQEYKGVFLKRGDMIL--LPTALHGLDDAANPEPWKLDFS-------RRSISHSTFGG 394 Query: 433 GKRVCAGEGLARMELFLLLCAILQ 456 G CAG LARME+ + L L+ Sbjct: 395 GPHRCAGMHLARMEVIVTLEEWLK 418 >2ZQJ-A nrPDB Length = 417 Score = 28.1 bits (61), Expect = 9.4, Method: Compositional matrix adjust. Identities = 23/90 (25%), Positives = 38/90 (42%), Gaps = 2/90 (2%) Query: 354 VHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEH 413 V E++R+ P L +D ++ KGT V+ L +D + + P++F+PE Sbjct: 280 VQEVRRYYPFGPF-LGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFRPER 338 Query: 414 FLN-ENGKFKYSDYFKPFSTGKRVCAGEGL 442 F E F + C GEG+ Sbjct: 339 FAEREENLFDMIPQGGGHAEKGHRCPGEGI 368 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3E6I-A nrPDB 654 0.0 2NNH-A nrPDB 591 e-169 5W0C-A nrPDB 590 e-169 4GQS-A nrPDB 589 e-169 1N6B-A nrPDB 579 e-165 4H1N-A nrPDB 549 e-156 3IBD-A nrPDB 529 e-150 2PG7-A nrPDB 527 e-150 5E58-A nrPDB 525 e-149 5E0E-A nrPDB 525 e-149 6B82-A nrPDB 443 e-125 3TBG-A nrPDB 426 e-119 6DWN-A nrPDB 420 e-118 3DL9-A nrPDB 418 e-117 4R20-A nrPDB 407 e-114 2HI4-A nrPDB 389 e-108 4R1Z-A nrPDB 388 e-108 5UYS-A nrPDB 386 e-107 5VBU-A nrPDB 381 e-106 3QZ1-A nrPDB 369 e-102 5YLW-A nrPDB 365 e-101 6IQ5-A nrPDB 361 e-100 6DA2-A nrPDB 341 4e-94 5VEU-A nrPDB 332 3e-91 6C94-A nrPDB 300 9e-82 3K9V-A nrPDB 289 2e-78 3MDV-A nrPDB 266 1e-71 6M7X-A nrPDB 255 3e-68 4ZGX-A nrPDB 253 1e-67 6AYB-A nrPDB 253 1e-67 3EL3-A nrPDB 241 6e-64 5FSA-A nrPDB 237 7e-63 5VWS-A nrPDB 234 5e-62 3JUS-A nrPDB 232 3e-61 2WX2-A nrPDB 226 2e-59 3S79-A nrPDB 225 3e-59 3L4D-A nrPDB 222 2e-58 5JLC-A nrPDB 222 3e-58 4WMZ-A nrPDB 216 2e-56 6CR2-A nrPDB 215 3e-56 2VE3-A nrPDB 212 2e-55 3MZS-A nrPDB 211 5e-55 2W0A-A nrPDB 209 2e-54 3EJB-B nrPDB 209 3e-54 3N9Z-A nrPDB 208 5e-54 6CVC-A nrPDB 205 4e-53 2X2N-A nrPDB 205 4e-53 5L94-A nrPDB 204 5e-53 4KPA-A nrPDB 204 5e-53 5Y1I-A nrPDB 204 1e-52 2WM5-A nrPDB 203 2e-52 2VZM-A nrPDB 201 6e-52 5CJE-A nrPDB 196 1e-50 2ZBZ-A nrPDB 196 2e-50 4RM4-A nrPDB 195 4e-50 4YZR-A nrPDB 194 5e-50 2Y5N-A nrPDB 193 1e-49 2Z36-A nrPDB 193 2e-49 5EX6-C nrPDB 191 4e-49 4OQS-A nrPDB 191 9e-49 4UBS-A nrPDB 189 2e-48 4GGV-A nrPDB 188 4e-48 4OQR-A nrPDB 188 7e-48 4TRI-A nrPDB 184 5e-47 5LIE-A nrPDB 184 5e-47 4WPZ-A nrPDB 184 9e-47 3A50-A nrPDB 181 6e-46 5IT1-A nrPDB 180 9e-46 5NWS-A nrPDB 179 2e-45 3SN5-A nrPDB 177 6e-45 6FSH-A nrPDB 176 2e-44 6GMF-A nrPDB 176 2e-44 3ABB-A nrPDB 176 3e-44 2XKR-A nrPDB 175 3e-44 5YSW-A nrPDB 175 3e-44 1UED-A nrPDB 174 5e-44 6B11-A nrPDB 174 6e-44 3WVS-A nrPDB 173 2e-43 4TX3-A nrPDB 172 2e-43 3TYW-A nrPDB 172 3e-43 4MM0-A nrPDB 171 5e-43 6A7I-A nrPDB 169 3e-42 6M7L-A nrPDB 167 9e-42 6GK6-A nrPDB 167 1e-41 3IVY-A nrPDB 164 6e-41 5DQN-A nrPDB 164 7e-41 3MGX-A nrPDB 163 1e-40 3TKT-A nrPDB 163 2e-40 3A1L-A nrPDB 163 2e-40 6F0B-A nrPDB 162 4e-40 5DE9-A nrPDB 159 3e-39 5LIV-A nrPDB 158 4e-39 6F88-A nrPDB 158 5e-39 2RFC-A nrPDB 157 1e-38 1Q5D-A nrPDB 147 7e-36 5FYF-A nrPDB 147 9e-36 6DCD-A nrPDB 140 2e-33 3OFT-A nrPDB 134 6e-32 1WIY-A nrPDB 130 2e-30 2IJ7-A nrPDB 125 3e-29 5M0P-A nrPDB 104 7e-23 3AWQ-A nrPDB 92 6e-19 Sequences not found previously or not previously below threshold: 5OFQ-A nrPDB 188 4e-48 4Z5P-A nrPDB 181 6e-46 5XW2-A nrPDB 178 6e-45 5XNT-A nrPDB 177 1e-44 2WIO-A nrPDB 177 1e-44 1Z8P-A nrPDB 176 2e-44 6A7J-A nrPDB 176 3e-44 1CPT-A nrPDB 174 7e-44 4YT3-A nrPDB 171 4e-43 1LG9-A nrPDB 171 5e-43 4JBT-A nrPDB 171 8e-43 5FOI-A nrPDB 171 8e-43 3ABA-A nrPDB 171 9e-43 3R9C-A nrPDB 170 1e-42 1EHE-A nrPDB 166 3e-41 5XJN-A nrPDB 164 1e-40 5GWE-A nrPDB 163 1e-40 4XE3-A nrPDB 160 1e-39 1ODO-A nrPDB 159 3e-39 4Z5Q-A nrPDB 158 6e-39 3P3Z-A nrPDB 156 2e-38 3NC3-A nrPDB 156 3e-38 1GWI-A nrPDB 156 3e-38 1F4U-A nrPDB 154 1e-37 3RWL-A nrPDB 150 1e-36 5Z9I-A nrPDB 150 1e-36 5L1U-A nrPDB 149 2e-36 1UE8-A nrPDB 144 8e-35 6HQG-A nrPDB 144 8e-35 4PWV-A nrPDB 144 1e-34 5HIW-A nrPDB 143 2e-34 6HQW-A nrPDB 142 2e-34 2UUQ-A nrPDB 142 5e-34 2FR7-A nrPDB 141 7e-34 2NZA-A nrPDB 141 1e-33 6BLD-A nrPDB 139 2e-33 5HDI-A nrPDB 137 1e-32 5H1Z-A nrPDB 136 3e-32 3OO3-A nrPDB 136 3e-32 4DO1-A nrPDB 135 4e-32 2X9P-A nrPDB 133 1e-31 5HH3-A nrPDB 133 2e-31 6GII-A nrPDB 132 3e-31 6HQD-A nrPDB 130 9e-31 6G5O-A nrPDB 126 2e-29 3WEC-A nrPDB 125 5e-29 5EX8-A nrPDB 122 5e-28 6G71-A nrPDB 118 7e-27 5D3U-A nrPDB 117 1e-26 4FB2-A nrPDB 117 1e-26 2WIY-A nrPDB 112 4e-25 3BUJ-A nrPDB 111 6e-25 5OMS-A nrPDB 110 1e-24 2QBO-A nrPDB 110 2e-24 5KYO-A nrPDB 109 2e-24 3B98-A nrPDB 108 5e-24 6FYJ-A nrPDB 105 4e-23 2IAG-A nrPDB 97 1e-20 3NV6-A nrPDB 96 2e-20 5YHJ-A nrPDB 96 4e-20 2ZQJ-A nrPDB 89 4e-18 4C9K-A nrPDB 87 2e-17 2RCM-A nrPDB 77 2e-14 3DBM-A nrPDB 66 5e-11 2YJN-B nrPDB 59 3e-09 3APY-A nrPDB 34 0.13 3J9E-D nrPDB 34 0.24 3ES8-A nrPDB 33 0.33 5L9W-B nrPDB 33 0.40 5H80-A nrPDB 32 0.73 6FEC-u nrPDB 30 2.7 4DJD-D nrPDB 30 3.4 3RFT-A nrPDB 29 3.9 2B8N-A nrPDB 29 6.5 3GFZ-A nrPDB 28 8.2 >3E6I-A nrPDB Length = 476 Score = 654 bits (1687), Expect = 0.0, Method: Composition-based stats. Identities = 464/472 (98%), Positives = 466/472 (98%) Query: 22 MWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81 M ++ S LPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH Sbjct: 1 MAKKTSSKGKLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 60 Query: 82 GYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQ 141 GYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQ Sbjct: 61 GYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQ 120 Query: 142 GNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMY 201 GNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMY Sbjct: 121 GNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMY 180 Query: 202 LFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNC 261 LFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNC Sbjct: 181 LFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNC 240 Query: 262 PRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEI 321 PRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEI Sbjct: 241 PRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEI 300 Query: 322 EEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGY 381 EEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGY Sbjct: 301 EEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGY 360 Query: 382 LIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEG 441 LIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEG Sbjct: 361 LIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEG 420 Query: 442 LARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS 493 LARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS Sbjct: 421 LARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS 472 >2NNH-A nrPDB Length = 476 Score = 591 bits (1523), Expect = e-169, Method: Composition-based stats. Identities = 270/471 (57%), Positives = 349/471 (74%), Gaps = 1/471 (0%) Query: 22 MWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81 M ++ S LPPGP PLPIIGN+ Q+++K+I KSFT ++ +GPVFT+Y G +VV H Sbjct: 1 MAKKTSSKGKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFH 60 Query: 82 GYKAVKEALLDYKDEFSGRGDLPAFH-AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGK 140 GY+AVKEAL+D +EFSGRG+ P + GII +NG WK+IRRFSLTTLRN+GMGK Sbjct: 61 GYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGK 120 Query: 141 QGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLM 200 + E R+Q EAH L+E LRKT+ P DPTF++GCAPCNVI ++F+K FDY D+ FL LM Sbjct: 121 RSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLM 180 Query: 201 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 260 FNENF +L++PW+Q+ NNFP + PG+H KV+KNVA + Y+ E+VKEH SLD N Sbjct: 181 KRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVN 240 Query: 261 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 320 PRD DC L++ME+EK + + + ++ + TVADLF AGTETTSTTLRYGLL+L+K+PE Sbjct: 241 NPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPE 300 Query: 321 IEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRG 380 + K+ EEID VIG R P ++DR MPY DAVVHEIQR+ LVP+ +PH T DT FR Sbjct: 301 VTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRN 360 Query: 381 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 440 YLIPKGT ++ L SVL+D++EFP+P F P HFL++NG FK SDYF PFS GKR+CAGE Sbjct: 361 YLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGE 420 Query: 441 GLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIP 491 GLARMELFL L ILQ+FNLK + D K+++ + + G +PP Y++C IP Sbjct: 421 GLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIP 471 >5W0C-A nrPDB Length = 477 Score = 590 bits (1520), Expect = e-169, Method: Composition-based stats. Identities = 273/472 (57%), Positives = 354/472 (75%), Gaps = 2/472 (0%) Query: 22 MWRQVHS-SWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVM 80 M ++ S LPPGP PLP+IGN+ Q+ +K+I KS T L++ +GPVFTLY G + +VV+ Sbjct: 1 MAKKTSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVL 60 Query: 81 HGYKAVKEALLDYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMG 139 HGY+AVKEAL+D +EFSGRG P A A+R GI+F+NG WK+IRRFSL TLRN+GMG Sbjct: 61 HGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMG 120 Query: 140 KQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL 199 K+ E R+Q EA L+E LRKT+ P DPTF++GCAPCNVI I+F K FDY D++FL L Sbjct: 121 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNL 180 Query: 200 MYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDP 259 M NEN +LS+PW+Q+ NNF + Y PG+H K++KNVA +K Y+ E+VKEH +S+D Sbjct: 181 MEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDM 240 Query: 260 NCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYP 319 N P+D DC L++MEKEKH+ +T++ + T DLF AGTETTSTTLRY LL+L+K+P Sbjct: 241 NNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 300 Query: 320 EIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFR 379 E+ K+ EEI+RVIG +R P ++DR MPY DAVVHE+QR+I L+P++LPH T D FR Sbjct: 301 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR 360 Query: 380 GYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAG 439 YLIPKGT ++ +L SVL+DN+EFP+PE F P HFL+E G FK S YF PFS GKR+C G Sbjct: 361 NYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVG 420 Query: 440 EGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIP 491 E LA MELFL L +ILQ+FNLK LVDPK++D +P+ GF +PP Y+LC IP Sbjct: 421 EALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIP 472 >4GQS-A nrPDB Length = 477 Score = 589 bits (1519), Expect = e-169, Method: Composition-based stats. Identities = 272/472 (57%), Positives = 360/472 (76%), Gaps = 2/472 (0%) Query: 22 MWRQVHS-SWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVM 80 M ++ S LPPGP PLP+IGN+ Q+++K++ KS T L++ +GPVFTLY G +RMVV+ Sbjct: 1 MAKKTSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVL 60 Query: 81 HGYKAVKEALLDYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMG 139 HGY+ VKEAL+D +EFSGRG P A A+R GI+F+NG WK+IRRFSL TLRN+GMG Sbjct: 61 HGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMG 120 Query: 140 KQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL 199 K+ E R+Q EA L+E LRKT+ P DPTF++GCAPCNVI I+F+K FDY D++FL L Sbjct: 121 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNL 180 Query: 200 MYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDP 259 M NEN ++STPW+Q+ NNFP+ + Y PG+H K++KN+A ++ + E+VKEH +S+D Sbjct: 181 MEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDI 240 Query: 260 NCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYP 319 N PRD DC L++MEKEK + + +T++ + +T ADL AGTETTSTTLRY LL+L+K+P Sbjct: 241 NNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP 300 Query: 320 EIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFR 379 E+ K+ EEI+RV+G +R P ++DR MPY DAVVHE+QR+I L+P++LPH T D FR Sbjct: 301 EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFR 360 Query: 380 GYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAG 439 YLIPKGT ++ +L SVL+DN+EFP+PE F P HFL+E G FK S+YF PFS GKR+C G Sbjct: 361 NYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVG 420 Query: 440 EGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIP 491 EGLARMELFL L ILQ+FNLK L+DPKD+D +P+ GF +PP Y+LC IP Sbjct: 421 EGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIP 472 >1N6B-A nrPDB Length = 473 Score = 579 bits (1492), Expect = e-165, Method: Composition-based stats. Identities = 262/471 (55%), Positives = 347/471 (73%), Gaps = 4/471 (0%) Query: 22 MWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81 M ++ S LPPGP P PIIGN+ Q++ K+I KS T+ ++ +GPVFT+Y+G + VV+H Sbjct: 1 MAKKTSSKGKLPPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLH 60 Query: 82 GYKAVKEALLDYKDEFSGRGDLPAF-HAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGK 140 GY+AVKEAL+D +EF+GRG +P + GI F+N TWK++RRFSL TLRN+GMGK Sbjct: 61 GYEAVKEALVDLGEEFAGRGSVPILEKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGK 120 Query: 141 QGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLM 200 + E RIQ EA L+E LRKT P DPTF++GCAPCNVI ++F FDY DE+FL+LM Sbjct: 121 RSIEDRIQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKLM 180 Query: 201 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 260 +EN LL TPWLQ+YNNFP+ L Y PG H+ ++KN +K ++ E+VKEH + LD N Sbjct: 181 ESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDVN 240 Query: 261 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 320 PRD DC L++ME+E + +T++ + + V+DLF AGTETTSTTLRY LL+L+K+PE Sbjct: 241 NPRDFIDCFLIKMEQENN---LEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPE 297 Query: 321 IEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRG 380 + ++ EEI+RVIG R P ++DR MPY DAV+HEIQRFI L+P+NLPH TRD FR Sbjct: 298 VAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRN 357 Query: 381 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 440 Y IPKGT ++ +L SVL+D + FP+P+ F P HFL+E+G FK SDYF PFS GKR+C GE Sbjct: 358 YFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGE 417 Query: 441 GLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIP 491 GLARMELFL L +ILQ+F L+ LV+PKD+D++ + GF +PP Y+LC IP Sbjct: 418 GLARMELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPSYQLCFIP 468 >4H1N-A nrPDB Length = 479 Score = 549 bits (1414), Expect = e-156, Method: Composition-based stats. Identities = 222/472 (47%), Positives = 313/472 (66%), Gaps = 1/472 (0%) Query: 22 MWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81 M ++ S LPPGP PLP++GNL Q++ K + +SF RL +++G VFT+Y+GS+ +VV+ Sbjct: 1 MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLC 60 Query: 82 GYKAVKEALLDYKDEFSGRGDLPAFH-AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGK 140 G A++EAL+D + FSGRG + + G+IF NG W+ +RRFSL T+R++GMGK Sbjct: 61 GTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFSLATMRDFGMGK 120 Query: 141 QGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLM 200 + E RIQ EA L+E LRK++G D T L N+I I+F K FDY D FLRL+ Sbjct: 121 RSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLL 180 Query: 201 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 260 LF ++F L+S+ Q++ F FL Y PG+HR++ +N+ E+ ++ + V++H +LDP+ Sbjct: 181 DLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPS 240 Query: 261 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 320 PRD D L+ MEK+K + + +TV LF AGTETTSTTLRYG L+++KYP Sbjct: 241 NPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLKYPH 300 Query: 321 IEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRG 380 + E++ +EI++VIG R PA+ DR +MPY DAV+HEIQR L+P +PH T+DT FRG Sbjct: 301 VTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRG 360 Query: 381 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 440 Y+IPK T V P L S L+D + F P F P HFL+ NG K ++ F PFS GKR+C GE Sbjct: 361 YVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGE 420 Query: 441 GLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492 G+AR ELFL ILQ+F++ V P+DIDL+P G G +PP Y++ + R Sbjct: 421 GIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNVPPSYQIRFLAR 472 >3IBD-A nrPDB Length = 476 Score = 529 bits (1363), Expect = e-150, Method: Composition-based stats. Identities = 222/472 (47%), Positives = 320/472 (67%), Gaps = 1/472 (0%) Query: 22 MWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81 M ++ S LPPGP PLP++GNL Q++ + + KSF R +++G VFT+++G + +V++ Sbjct: 1 MAKKTSSKGKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC 60 Query: 82 GYKAVKEALLDYKDEFSGRGDLPAFH-AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGK 140 G +A++EAL+D + FSGRG + R G+IF NG WK +RRFS+TT+R++GMGK Sbjct: 61 GVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK 120 Query: 141 QGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLM 200 + E RIQ EA L+E LRK++G DPTFL N+I I+F K F Y D++FL+++ Sbjct: 121 RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 180 Query: 201 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 260 LF + F L+S+ + QL+ F FL + PG+HR+V KN+ E+ Y+ V++H ++LDP+ Sbjct: 181 NLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPS 240 Query: 261 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 320 PRDL D L+ MEKEK +A ++ + + LFFAGTETTSTTLRYG L+++KYP Sbjct: 241 APRDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 300 Query: 321 IEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRG 380 + E+++ EI++VIGP R P + DR +MPY +AV++EIQRF L+P +PH T+ T FRG Sbjct: 301 VAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG 360 Query: 381 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 440 Y+IPK T V L + L+D F P+ F P+HFL+ NG K ++ F PFS GKR+C GE Sbjct: 361 YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGE 420 Query: 441 GLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492 G+AR ELFL ILQ+F++ V P+DIDL+P G G IPP Y++ +PR Sbjct: 421 GIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 472 >2PG7-A nrPDB Length = 476 Score = 527 bits (1357), Expect = e-150, Method: Composition-based stats. Identities = 224/472 (47%), Positives = 316/472 (66%), Gaps = 1/472 (0%) Query: 22 MWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81 M ++ S LPPGP PLP IGN QL + + S ++++R+GPVFT+++G +R+VV+ Sbjct: 1 MAKKTSSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLC 60 Query: 82 GYKAVKEALLDYKDEFSGRGDLPAFH-AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGK 140 G+ AV+EAL+D +EFSGRG+ F + G++F+NG K +RRFS+ TLR++G+GK Sbjct: 61 GHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGK 120 Query: 141 QGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLM 200 +G E RIQ EA FL++ALR T G DPTF + NVI+ I+F FDY D++FL L+ Sbjct: 121 RGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLL 180 Query: 201 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 260 + F ST QLY F S + +LPG ++ + + ++++++++V+ + ++LDPN Sbjct: 181 RMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPN 240 Query: 261 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 320 PRD D L+ M++E+ + + + + +T LF GTET STTLRYG L+LMK+PE Sbjct: 241 SPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPE 300 Query: 321 IEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRG 380 +E K+HEEIDRVIG +R P +DR +MPYM+AV+HEIQRF ++P +L +DT FR Sbjct: 301 VEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRD 360 Query: 381 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 440 + +PKGT V P L SVL D F +P+ F P+HFLNE G+FK SD F PFS GKR C GE Sbjct: 361 FFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGE 420 Query: 441 GLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492 GLARMELFL ++Q+F LK PKDID+SP H+GF IP Y + +PR Sbjct: 421 GLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 472 >5E58-A nrPDB Length = 493 Score = 525 bits (1352), Expect = e-149, Method: Composition-based stats. Identities = 217/450 (48%), Positives = 305/450 (67%), Gaps = 1/450 (0%) Query: 44 NLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDL 103 NL Q++ SF R+ +++G VFT+++G + +V+++G +A++EAL+D + FSGRG + Sbjct: 42 NLLQMDRGGFLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 101 Query: 104 PAFH-AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQ 162 D G+IF+NG WK +RRFSL T+R++GMGK+ E RIQ EA L+E L+K+Q Sbjct: 102 AVIKPVIGDYGMIFSNGERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVEELQKSQ 161 Query: 163 GQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFP 222 G P DPTFL C N+I I+F + +DY D +FLRL+ LF F L+S+ Q++ F Sbjct: 162 GAPLDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFS 221 Query: 223 SFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAER 282 F+ Y PG+HR++ +N+ E+ +YV + V++H +LDP+ PRD D L+ MEKEK + Sbjct: 222 GFMKYFPGAHRQITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSNQHT 281 Query: 283 LYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIK 342 + + ++V LFFAGTETTSTTLRYG L+++KYP + EK+ +EID+VIG R+P ++ Sbjct: 282 EFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLE 341 Query: 343 DRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQE 402 DR +MPY DAV+HEIQRF L P PH+ T+DT+FRGYL+PK T V P L S L+D Q Sbjct: 342 DRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 401 Query: 403 FPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKP 462 F P F P+HFL+ NG K S+ F PFS GKR+C GEG+AR ELFL ILQ+F++ Sbjct: 402 FEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSVSS 461 Query: 463 LVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492 V PKDIDLSP G G +P Y++ + R Sbjct: 462 SVAPKDIDLSPKESGIGKVPQTYQISFLAR 491 >5E0E-A nrPDB Length = 463 Score = 525 bits (1352), Expect = e-149, Method: Composition-based stats. Identities = 218/450 (48%), Positives = 311/450 (69%), Gaps = 1/450 (0%) Query: 44 NLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDL 103 NL Q++ SF R+ +++G VFT+++G + +V+++G +A++EAL+D + FSGRG + Sbjct: 14 NLLQMDRGGFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 73 Query: 104 PAFH-AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQ 162 R G++F NG WK +RRFSL T+R++GMGK+ E RIQ EA L+E RK+Q Sbjct: 74 AVVEPIFRGYGVVFANGERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEFRKSQ 133 Query: 163 GQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFP 222 G P DPTFL C N+I I+F + FDY D +FLRL+YLF ++F L+S+ Q++ F Sbjct: 134 GAPLDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFS 193 Query: 223 SFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAER 282 FL Y PG+HR++ +N+ E+ +Y+ + V++H +LDP+ PRD D L+ MEKEK + Sbjct: 194 GFLKYFPGTHRQISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSNQHT 253 Query: 283 LYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIK 342 + + ++V LFFAGTET+STTLRYG L+++KYP + EK+ +EID+VIG R+P ++ Sbjct: 254 EFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLE 313 Query: 343 DRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQE 402 DR +MPY +AV++EIQRF L+P +PH+ T+DT+FRGYL+PK T V P L S L+D Q Sbjct: 314 DRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 373 Query: 403 FPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKP 462 F P+ F P+HFL+ NG K S+ F PFS GKR+C GEG+AR ELFL ILQ+F+L Sbjct: 374 FEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSLSS 433 Query: 463 LVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492 V PKDIDLSP GFG +P Y++C + R Sbjct: 434 PVAPKDIDLSPKESGFGKVPQTYQICFLAR 463 >6B82-A nrPDB Length = 509 Score = 443 bits (1139), Expect = e-125, Method: Composition-based stats. Identities = 144/498 (28%), Positives = 238/498 (47%), Gaps = 32/498 (6%) Query: 22 MWRQVHSSWNL-------------PPGPFPLPIIGNLFQLELKNIPKSFTR-LAQRFGPV 67 M ++ S PP LPIIG+L L + P F + L +++G + Sbjct: 1 MAKKTSSKGKKQKMNGFVPAGNRSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDL 60 Query: 68 FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHR--DRGIIFNNGP-TWKD 124 ++L +GS ++++++ + KE L+ F+GR + I F + TWK Sbjct: 61 YSLMMGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKF 120 Query: 125 IRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADIL 184 R+ L +G G E I REA + E L ++Q D + A NV+ + Sbjct: 121 HRKMVHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALC 180 Query: 185 FRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKE 244 F + D +F ++ ++ L + FP +L P ++++ +++ Sbjct: 181 FNSSYKRGDAEFESMLQYSQGIVDTVAKD--SLVDIFP-WLQIFPNKDLRILRQCISIRD 237 Query: 245 -YVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERL----YTMDGITVTVADLFFA 299 + ++ +EH + N RDL D LL +++ T D + +TV ++F A Sbjct: 238 KLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGA 297 Query: 300 GTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQR 359 G ETT+TTL++ + L+ P+++ K+ EE+D IG R P + DR +PY++A + E+ R Sbjct: 298 GVETTTTTLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMR 357 Query: 360 FITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENG 419 + P +PH A +D+ Y + KGT VV + S+ +D +E+ +PE F P FLNE G Sbjct: 358 IRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEG 417 Query: 420 KFK--YSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIG 477 S + PF G RVC GE LA+MELFL L ILQ F L+ P L + Sbjct: 418 DGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEM---PTGQPLPDLQGK 474 Query: 478 FGCI--PPRYKLCVIPRS 493 FG + P ++K+ R+ Sbjct: 475 FGVVLQPKKFKVVAKVRA 492 >3TBG-A nrPDB Length = 479 Score = 426 bits (1094), Expect = e-119, Method: Composition-based stats. Identities = 189/479 (39%), Positives = 271/479 (56%), Gaps = 12/479 (2%) Query: 22 MWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81 M ++ S LPPGP PLP +GNL ++ +N P F +L +RFG VF+L + +VV++ Sbjct: 1 MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN 60 Query: 82 GYKAVKEALLDYKDEFSGRGDLPAFH----AHRDRGIIFNN-GPTWKDIRRFSLTTLRNY 136 G AV+EAL+ + ++ + R +P R +G+ GP W++ RRFS++TLRN Sbjct: 61 GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL 120 Query: 137 GMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKF 196 G+GK+ E + EA L A G+PF P L+ A NVIA + + F+Y+D +F Sbjct: 121 GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF 180 Query: 197 LRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQS 256 LRL+ L E S ++ N P LH P KV++ + E + EH + Sbjct: 181 LRLLDLAQEGLKEESGFLREVLNAVPVLLHI-PALAGKVLRFQKAFLTQLDELLTEHRMT 239 Query: 257 LDP-NCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLIL 315 DP PRDLT+ L EMEK K + E + + + + VADLF AG TTSTTL +GLL++ Sbjct: 240 WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM 299 Query: 316 MKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRD 375 + +P+++ ++ +EID VIG R P + D+ MPY AV+HE+QRF +VP + H +RD Sbjct: 300 ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRD 359 Query: 376 TIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKR 435 +G+ IPKGT ++ L SVL D + P +F PEHFL+ G F + F PFS G+R Sbjct: 360 IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR 419 Query: 436 VCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFG--CIPPRYKLCVIPR 492 C GE LARMELFL ++LQHF+ P H F P Y+LC +PR Sbjct: 420 ACLGEPLARMELFLFFTSLLQHFSFSV---PTGQPRPSHHGVFAFLVSPSPYELCAVPR 475 >6DWN-A nrPDB Length = 491 Score = 420 bits (1079), Expect = e-118, Method: Composition-based stats. Identities = 145/473 (30%), Positives = 245/473 (51%), Gaps = 23/473 (4%) Query: 22 MWRQVHSSW-NLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVM 80 M ++ S PPGP+ P+IG++ L KN + +R++Q++G V + +GS +VV+ Sbjct: 1 MAKKTSSKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVL 59 Query: 81 HGYKAVKEALLDYKDEFSGRGDLPAFHAH-RDRGIIFN--NGPTWKDIRRFSLTTLRNYG 137 G +++AL+ D+F GR DL F + + F+ +GP W RR + L+++ Sbjct: 60 SGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFS 119 Query: 138 MGKQG-------NESRIQREAHFLLEALRKTQGQP--FDPTFLIGCAPCNVIADILFRKH 188 + E + +EA L+ L++ P F+P + + NVI I F + Sbjct: 120 IASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRR 179 Query: 189 FDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAE-VKEYVS 247 +D+N ++ L L+ L N ++ + +F L YLP K++ E ++ Sbjct: 180 YDHNHQELLSLVNLNNNFGEVVGSGNPA---DFIPILRYLPNPSLNAFKDLNEKFYSFMQ 236 Query: 248 ERVKEHHQSLDPNCPRDLTDCLLVEMEKEK--HSAERLYTMDGITVTVADLFFAGTETTS 305 + VKEH+++ + RD+TD L+ ++++ +A + + I V DLF AG +T + Sbjct: 237 KMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVT 296 Query: 306 TTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVP 365 T + + L+ L+ P ++ K+ EE+D VIG SR P + DR +PYM+A + E R + VP Sbjct: 297 TAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVP 356 Query: 366 SNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKY-- 423 +PH TRDT +G+ IPKG V + +D + + +P +F PE FL +G Sbjct: 357 FTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVL 416 Query: 424 SDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHI 476 S+ F GKR C GE +AR E+FL L +LQ + K +D++PI+ Sbjct: 417 SEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTPIYG 468 >3DL9-A nrPDB Length = 479 Score = 418 bits (1075), Expect = e-117, Method: Composition-based stats. Identities = 161/456 (35%), Positives = 256/456 (56%), Gaps = 12/456 (2%) Query: 44 NLFQLELKN--IPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRG 101 N++ L + + +Q +G +F+L +G VV++GY VKE L+ + F+ R Sbjct: 25 NIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRP 84 Query: 102 DLPAFHAHRDRGIIFNN--GPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALR 159 LP F G + N+ G W D RR ++ + R +G G++ ES+I E F +A+ Sbjct: 85 CLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIE 144 Query: 160 KTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYN 219 +G+PFD LI A N+ I+F + F Y D F ++ LF+EN L ++ + LYN Sbjct: 145 TYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYN 204 Query: 220 NFPSFLHYLP-GSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKH 278 FP ++ LP G H+++ +N A V +++S +++ + P P+ D L EM++ K+ Sbjct: 205 AFP-WIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKN 263 Query: 279 SAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRI 338 ++ + + +V +L AGTETT+ LR+ +L + YP I+ ++ +EID ++GP+ Sbjct: 264 DPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGK 323 Query: 339 PAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLY 398 P+ D+ +MPY +AV+HE+ RF +VP + H + D + RGY IPKGT V+ L SV + Sbjct: 324 PSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHF 383 Query: 399 DNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 D + + DPE F PE FL+ +G F + PFS G+R C GE LARME+FL A+LQ F Sbjct: 384 DEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRF 443 Query: 459 NLKPLVDPKDI--DLSPIHIGFGCIPPRYKLCVIPR 492 +L P ++ DL P +G P Y +C R Sbjct: 444 HLH---FPHELVPDLKP-RLGMTLQPQPYLICAERR 475 >4R20-A nrPDB Length = 486 Score = 407 bits (1046), Expect = e-114, Method: Composition-based stats. Identities = 148/486 (30%), Positives = 239/486 (49%), Gaps = 22/486 (4%) Query: 22 MWRQVHSSWNLPPGPFP--LPIIGNLFQLELKN-------IPKSFTRLAQRFGPVFTLYV 72 M ++ S G P + L L FT+L+ ++GP+F LY Sbjct: 1 MAKKTSSKGKEGVGSSSVSFPCLPRLPLLGSLLHLRSNLPPHLLFTQLSSQYGPLFGLYA 60 Query: 73 GSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPA--FHAHRDRGIIFNNG-PTWKDIRRFS 129 G +V+ V+E LL EF+GR + + I F + P WK+ RR Sbjct: 61 GPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQGGKDIAFADYSPLWKNHRRLV 120 Query: 130 LTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHF 189 ++ +G G ++ +Q A L E L+ +GQ D + ++ A NVI ++F + Sbjct: 121 HSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSDLSVVLMRAVTNVICRLVFSSSY 180 Query: 190 DYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKE-YVSE 248 +D + ++ + ++ L + FP +L P K +K +++ + + Sbjct: 181 QPSDPELQTVIQYNDGIVQTIA--RGGLVDIFP-WLRIFPNKDLKRLKECVSIRDQLLYK 237 Query: 249 RVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTL 308 ++ EH +SL P PRDL D LL+ ++ T D + +T A+ F AG ETTSTTL Sbjct: 238 KLLEHKKSLTPGEPRDLLDALLIGQQRGSG-GADDITEDHVLMTAAEAFGAGVETTSTTL 296 Query: 309 RYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNL 368 + + L+ +P+++E++ E+D +G R P + DR +P +DAV+ E+ R + P + Sbjct: 297 LWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPHLPLLDAVLCEVMRIRPVSPILI 356 Query: 369 PHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFK 428 PH A +DT G+ +PKGT V+ + ++ +D + + PE+F PE FL +GK K F Sbjct: 357 PHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQPEQFNPERFLEPSGKKKTQSSFL 416 Query: 429 PFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCI--PPRYK 486 PF G RVC GE LAR+ELFL + LQ F+ P + L + FG + P RY Sbjct: 417 PFGAGPRVCVGESLARIELFLFVSRPLQRFSFS---CPSEASLPDLQGRFGVVLQPERYT 473 Query: 487 LCVIPR 492 + V PR Sbjct: 474 VTVTPR 479 >2HI4-A nrPDB Length = 495 Score = 389 bits (1000), Expect = e-108, Method: Composition-based stats. Identities = 142/475 (29%), Positives = 234/475 (49%), Gaps = 21/475 (4%) Query: 18 LLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRM 77 +L + +V PP P+ P++G++ L KN + +R++QR+G V + +GS + Sbjct: 3 VLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPV 61 Query: 78 VVMHGYKAVKEALLDYKDEFSGRGDLPA-FHAHRDRGIIFN--NGPTWKDIRRFSLTTLR 134 +V+ +++AL+ D+F GR DL + + F+ +GP W RR + L Sbjct: 62 LVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALN 121 Query: 135 NYGMGKQG-------NESRIQREAHFLLEALRKTQGQP--FDPTFLIGCAPCNVIADILF 185 + + E + +EA L+ L++ P FDP + + NVI + F Sbjct: 122 TFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCF 181 Query: 186 RKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAE-VKE 244 +HF + ++ L L+ +E S+ + FP L YLP + K + Sbjct: 182 GQHFPESSDEMLSLVKNTHEFVETASSG--NPLDFFP-ILRYLPNPALQRFKAFNQRFLW 238 Query: 245 YVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETT 304 ++ + V+EH+Q D N RD+T L +K ++ L + I V D+F AG +T Sbjct: 239 FLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 298 Query: 305 STTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLV 364 +T + + L+ L+ PEI+ K+ +E+D VIG R P + DR ++PY++A + E R + + Sbjct: 299 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 358 Query: 365 PSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKF--- 421 P +PH TRDT G+ IPK V V +D + + DP +F+PE FL +G Sbjct: 359 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 418 Query: 422 KYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHI 476 S+ F GKR C GE LA+ E+FL L +LQ K +DL+PI+ Sbjct: 419 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVK-VDLTPIYG 472 >4R1Z-A nrPDB Length = 439 Score = 388 bits (996), Expect = e-108, Method: Composition-based stats. Identities = 129/434 (29%), Positives = 209/434 (48%), Gaps = 18/434 (4%) Query: 72 VGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHR--DRGIIFNNGP-TWKDIRRF 128 +GS ++++++ + KE L+ F+GR + I F + TWK R+ Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKM 60 Query: 129 SLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKH 188 L +G G E I REA + E L ++Q D + A NV+ + F Sbjct: 61 VHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSS 120 Query: 189 FDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKE-YVS 247 + D +F ++ ++ L + FP +L P +++ +++ + Sbjct: 121 YKRGDAEFESMLQYSQGIVDTVAKD--SLVDIFP-WLQIFPNKDLTILRQCISIRDKLLQ 177 Query: 248 ERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERL----YTMDGITVTVADLFFAGTET 303 ++ +EH + N RDL D LL +++ T D + +TV D+F AG ET Sbjct: 178 KKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFGAGVET 237 Query: 304 TSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITL 363 T+T L++ + L+ P+++ K+ EE+D IG R P + DR +PY++A + E+ R + Sbjct: 238 TTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPV 297 Query: 364 VPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFK- 422 P +PH A +D+ Y + KGT VV L S+ +D +E+ +PE F P FLNE G Sbjct: 298 SPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEGDGLC 357 Query: 423 -YSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCI 481 S + PF G RVC GE LA+MELFL L ILQ F L+ P L + FG + Sbjct: 358 CPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEM---PTGQPLPDLQGKFGVV 414 Query: 482 --PPRYKLCVIPRS 493 P ++K+ R+ Sbjct: 415 LQPKKFKVVAKVRA 428 >5UYS-A nrPDB Length = 494 Score = 386 bits (991), Expect = e-107, Method: Composition-based stats. Identities = 129/484 (26%), Positives = 245/484 (50%), Gaps = 19/484 (3%) Query: 22 MWRQVHSSWNLPPGPFPLPIIGNL-FQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVM 80 M ++ + P LP++G+L F ++ +F +L +++GP++++ +G++ V++ Sbjct: 1 MAKKTGA--KYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIV 58 Query: 81 HGYKAVKEALLDYKDEFSGRGDLPAFH--AHRDRGIIFNN-GPTWKDIRRFSLTTLRNYG 137 ++ KE L+ +FSGR + ++ +GI F + G W+ RR ++ T + Sbjct: 59 GHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFK 118 Query: 138 MGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFL 197 G Q E I +E L + L GQ D +F + A NVI+ I F + D + L Sbjct: 119 DGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE-L 177 Query: 198 RLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVK-EYVSERVKEHHQS 256 ++ +NE ++ + +L P + +K+ +++ + +++ ++ + + Sbjct: 178 NVIQNYNE--GIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK 235 Query: 257 LDPNCPRDLTDCLLVE-MEKEKHSAE-----RLYTMDGITVTVADLFFAGTETTSTTLRY 310 + ++ D L+ M + +A L + + I T+ D+F AG ETT++ +++ Sbjct: 236 FRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 295 Query: 311 GLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPH 370 L L+ P++++KL+EEID+ +G SR P I DR + ++A + E+ R + P +PH Sbjct: 296 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 355 Query: 371 EATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK--FKYSDYFK 428 +A D+ + + KGT V+ L ++ ++ +E+ P++F PE FLN G S + Sbjct: 356 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYL 415 Query: 429 PFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLC 488 PF G R C GE LAR ELFL++ +LQ F+L+ D + L I I +K+ Sbjct: 416 PFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLI-DSFKVK 474 Query: 489 VIPR 492 + R Sbjct: 475 IKVR 478 >5VBU-A nrPDB Length = 476 Score = 381 bits (978), Expect = e-106, Method: Composition-based stats. Identities = 126/481 (26%), Positives = 220/481 (45%), Gaps = 26/481 (5%) Query: 22 MWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 81 M ++ S LPP + L ++P L Q+FGP++ L++G Q +VV++ Sbjct: 1 MAKKTSSKGKLPP------LAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLN 54 Query: 82 GYKAVKEALLDYKDEFSGRGDLPAFHAHRDR--GIIFNNGPT-WKDIRRFSLTTLRNYGM 138 + ++EA++ +F+GR + + + + WK ++ + + L Sbjct: 55 SKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLG-- 112 Query: 139 GKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLR 198 + E +++ E +R G P C++I + F +D Sbjct: 113 IRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPA 171 Query: 199 LMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSE-RVKEHHQSL 257 E S +Q+ + P FL + P + +K E ++++ E ++++H +SL Sbjct: 172 YYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESL 230 Query: 258 DPNCPRDLTDCLLVEMEKEKHSAERLYTMDG-ITVTVADLFFAGTETTSTTLRYGLLILM 316 RD+ D +L + + ++G + + DL GTETT+ TL + ++ L+ Sbjct: 231 VAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLL 290 Query: 317 KYPEIEEKLHEEIDRVIGP---SRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEAT 373 +PEI+++L EE+D +GP S KDR +P ++A + E+ R +VP LPH T Sbjct: 291 HHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTT 350 Query: 374 RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTG 433 R + GY IP+GTV++P L D + P +F P+ FL + F G Sbjct: 351 RPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEP----GKNSRALAFGCG 406 Query: 434 KRVCAGEGLARMELFLLLCAILQHFNLKPLVD--PKDIDLSPIHIGFGCIPPRYKLCVIP 491 RVC GE LAR+ELF++L +LQ F L P D P L + P +++ + P Sbjct: 407 ARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQP--FQVRLQP 464 Query: 492 R 492 R Sbjct: 465 R 465 >3QZ1-A nrPDB Length = 496 Score = 369 bits (948), Expect = e-102, Method: Composition-based stats. Identities = 126/462 (27%), Positives = 216/462 (46%), Gaps = 19/462 (4%) Query: 40 PIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSG 99 P++ L N+P L Q+ GPV+ L +G Q +VV++ + ++EA++ +F+G Sbjct: 32 PLVPGFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAG 91 Query: 100 RGDLPAFHAHRDRGIIFNNGP---TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLE 156 R +P++ R + G WK ++ + + L + E + + E Sbjct: 92 RPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSALLLG--TRSSMEPWVDQLTQEFCE 149 Query: 157 ALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQ 216 +R G P C++I + F D F + +Q Sbjct: 150 RMRVQAGAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDL---MKTWDHWSIQ 206 Query: 217 LYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSER-VKEHHQSLDPNCPRDLTDCLLVEMEK 275 + + P FL + P +K E ++++ E+ ++ H +S+ RD+TD +L + + Sbjct: 207 ILDMVP-FLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDYMLQGVGR 265 Query: 276 EKHSAERLYTMDG-ITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIG 334 ++ ++G + ++V DLF GTETT++TL + + L+ +PEI+ +L EE+DR +G Sbjct: 266 QRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELDRELG 325 Query: 335 PS---RIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVP 391 P KDR +P ++A + E+ R +VP LPH TR + GY IP+G VV+P Sbjct: 326 PGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMVVIP 385 Query: 392 TLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLL 451 L D + P +F+P+ FL + F G RVC GE LAR+ELF++L Sbjct: 386 NLQGAHLDETVWEQPHEFRPDRFLEP----GANPSALAFGCGARVCLGESLARLELFVVL 441 Query: 452 CAILQHFNLKPLVDPKDIDLSPI-HIGFGCIPPRYKLCVIPR 492 +LQ F L P L P + G +++ + PR Sbjct: 442 ARLLQAFTLLPPPVGALPSLQPDPYCGVNLKVQPFQVRLQPR 483 >5YLW-A nrPDB Length = 495 Score = 365 bits (936), Expect = e-101, Method: Composition-based stats. Identities = 131/478 (27%), Positives = 219/478 (45%), Gaps = 26/478 (5%) Query: 1 MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60 M + + AL AA + +S R+ NLPPGPFP PI+GN+ QL N + F +L Sbjct: 1 MDSFPLLAALFFIAATITFLSFRRR----RNLPPGPFPYPIVGNMLQLGA-NPHQVFAKL 55 Query: 61 AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP 120 ++R+GP+ ++++GS V++ + KE L + FSGR A HA I P Sbjct: 56 SKRYGPLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDKISMGFLP 115 Query: 121 ---TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQ--GQPFDPTFLIGCA 175 W+D+R+ + + ++ +++ LL+ ++K G+ D Sbjct: 116 VASEWRDMRKICKEQM-FSNQSMEASQGLRRQKLQQLLDHVQKCSDSGRAVDIREAAFIT 174 Query: 176 PCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLST--PWLQLYNNFPSFLHYLPGSHR 233 N+++ LF D K F E ++T + FP + P + Sbjct: 175 TLNLMSATLFSSQATEFDSK---ATMEFKEIIEGVATIVGVPNFADYFPILRPFDPQGVK 231 Query: 234 KVI-----KNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDG 288 + K +A+++ Y++ER++ + PN P+ D L + + E Sbjct: 232 RRADVFFGKLLAKIEGYLNERLESKRAN--PNAPKK--DDFLEIVVDIIQANEFKLKTHH 287 Query: 289 ITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMP 348 T + DLF G++T +T++ + + L+ P+ +L E+ V G +I ++P Sbjct: 288 FTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDESAMPKLP 347 Query: 349 YMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEK 408 Y+ AV+ E+ R P LP +A D GYLIPKGT ++ ++ D + DPE Sbjct: 348 YLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSIWTDPET 407 Query: 409 FKPEHFLNENGKFKYSDY-FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVD 465 F PE FL+ FK DY PF +G+RVC G LA L + ++ +F+ K D Sbjct: 408 FDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNFDWKLEDD 465 >6IQ5-A nrPDB Length = 463 Score = 361 bits (926), Expect = e-100, Method: Composition-based stats. Identities = 132/458 (28%), Positives = 225/458 (49%), Gaps = 24/458 (5%) Query: 54 PKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHA-HRDR 112 SF RLA+R+G VF + +GS +VV++G +A+ +AL+ F+ R +F R Sbjct: 4 HLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGR 63 Query: 113 GIIFNNG-PTWKDIRRFSLTTLRNY----GMGKQGNESRIQREAHFLLEALRK--TQGQP 165 + F + WK RR + + +RN+ +Q E + EA L+ L + G Sbjct: 64 SMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAF 123 Query: 166 FDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFL 225 DP L A NV++ + F + ++D +F L+ E + L + +L Sbjct: 124 LDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL---VDVMPWL 180 Query: 226 HYLPGSHRKVIKNVAEVK----EYVSERVKEHHQSLDPNC-PRDLTDCLLVEMEK----E 276 Y P R V + ++ ++ ++ H +SL P PRD+ D ++ EK + Sbjct: 181 QYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGD 240 Query: 277 KHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPS 336 H ++ + T+ D+F A +T ST L++ LL+ +YP+++ ++ E+D+V+G Sbjct: 241 SHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRD 300 Query: 337 RIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSV 396 R+P + D+ +PY+ A ++E RF + VP +PH T +T GY IPK TVV SV Sbjct: 301 RLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSV 360 Query: 397 LYDNQEFPDPEKFKPEHFLNENGKFKY--SDYFKPFSTGKRVCAGEGLARMELFLLLCAI 454 +D ++P+PE F P FL+++G + FS GKR C GE L++M+LFL + + Sbjct: 361 NHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISIL 420 Query: 455 LQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492 + + +P + G P +K+ V R Sbjct: 421 AHQCDFR--ANPNEPAKMNFSYGLTIKPKSFKVNVTLR 456 >6DA2-A nrPDB Length = 487 Score = 341 bits (875), Expect = 4e-94, Method: Composition-based stats. Identities = 108/437 (24%), Positives = 179/437 (40%), Gaps = 16/437 (3%) Query: 34 PGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD- 92 PGP PLP +GN+ K +++G V+ Y G Q ++ + +K L+ Sbjct: 19 PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 77 Query: 93 YKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAH 152 F+ R I WK +R T + + + I + Sbjct: 78 CYSVFTNRRPFGPV-GFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMV--PIIAQYGD 134 Query: 153 FLLEALRKTQ--GQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHL- 209 L+ LR+ G+P + G +VI F + D + + + Sbjct: 135 VLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFD 194 Query: 210 LSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCL 269 P+ FP + L + V EV ++ + VK +S + + D L Sbjct: 195 FLDPFFLSITVFPFLIPILEVLNICVF--PREVTNFLRKSVKRMKESRLEDTQKHRVDFL 252 Query: 270 LVEME----KEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKL 325 + ++ KE S + L ++ + ++ FAG ETTS+ L + + L +P++++KL Sbjct: 253 QLMIDSQNSKETESHKALSDLELVAQSII-FIFAGYETTSSVLSFIMYELATHPDVQQKL 311 Query: 326 HEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPK 385 EEID V+ P +M Y+D VV+E R + L +D G IPK Sbjct: 312 QEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPK 370 Query: 386 GTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARM 445 G VV+ ++ D + + +PEKF PE F +N + PF +G R C G A M Sbjct: 371 GVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALM 430 Query: 446 ELFLLLCAILQHFNLKP 462 + L L +LQ+F+ KP Sbjct: 431 NMKLALIRVLQNFSFKP 447 >5VEU-A nrPDB Length = 480 Score = 332 bits (850), Expect = 3e-91, Method: Composition-based stats. Identities = 103/437 (23%), Positives = 181/437 (41%), Gaps = 17/437 (3%) Query: 34 PGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD- 92 PGP PLP++GN+ + + K T +++G ++ Y G ++ + ++ L+ Sbjct: 18 PGPTPLPLLGNVLSY-RQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 76 Query: 93 YKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAH 152 F+ R L I WK IR T + + + I + Sbjct: 77 CYSVFTNRRSLGPV-GFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMF--PIIAQYGD 133 Query: 153 FLLEALRKT--QGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHL- 209 L+ LR+ +G+P + G +VI F + D + + + Sbjct: 134 VLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFG 193 Query: 210 LSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCL 269 P FP + + + ++S+ V +S + + D L Sbjct: 194 FLDPLFLSIILFPFLTPVFEALNVSLF--PKDTINFLSKSVNRMKKSRLNDKQKHRLDFL 251 Query: 270 LVEME----KEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKL 325 + ++ KE S + L ++ ++ FAG ETTS+ L + L L +P++++KL Sbjct: 252 QLMIDSQNSKETESHKALSDLELAAQSII-FIFAGYETTSSVLSFTLYELATHPDVQQKL 310 Query: 326 HEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPK 385 +EID V+ P +M Y+D VV+E R + L +D G IPK Sbjct: 311 QKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFIPK 369 Query: 386 GTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARM 445 G++VV ++ +D + + +PE+F+PE F + + PF TG R C G A M Sbjct: 370 GSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDP-YIYTPFGTGPRNCIGMRFALM 428 Query: 446 ELFLLLCAILQHFNLKP 462 + L L +LQ+F+ KP Sbjct: 429 NMKLALIRVLQNFSFKP 445 >6C94-A nrPDB Length = 497 Score = 300 bits (768), Expect = 9e-82, Method: Composition-based stats. Identities = 97/467 (20%), Positives = 182/467 (38%), Gaps = 43/467 (9%) Query: 34 PGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDY 93 PGP + G+ +++ Q+F L+VG G+ + E DY Sbjct: 25 PGPPTHWLFGHALEIQKTGSLDKVVTWTQQFPYAHPLWVGQ-----FIGFLNIYEP--DY 77 Query: 94 KDEFSGRGDLPA------FHAHRDRGIIFNNGPTWKDIRR-----FSLTTLRNYGMGKQG 142 RGD A F +G++ +GP W R+ F L+ Y + Sbjct: 78 AKAVYSRGDPKAPDVYDFFLQWIGKGLLVLDGPKWFQHRKLLTPGFHYDVLKPY-VAIFA 136 Query: 143 NESRIQREAHFLLEALRK--TQGQPFDPTFLIGCAPCNVIADILFRKH---FDYNDEKFL 197 + +RI +LE K +G+ FD +G + + F K ++ D + Sbjct: 137 DSTRI------MLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSY- 189 Query: 198 RLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSL 257 Y+ LL + + F+++L R+ ++ ++ +++ +L Sbjct: 190 ---YVAVSELTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACRAAHDHTDRVIRQRKAAL 246 Query: 258 DPNCPRDLT------DCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYG 311 R+ D L + ++ S +L D + V F G +TT++ + + Sbjct: 247 QDEKEREKIQNRRHLDFLDILLDVRGESGVQLSDTD-LRAEVDTFMFEGHDTTTSGISWF 305 Query: 312 LLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHE 371 L + YPE +++ EE+ ++G +D +M Y+ + E R VP Sbjct: 306 LYCMALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQL 365 Query: 372 ATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFS 431 + + G +P G+++ + ++ ++ +PDPE F P F EN ++ F PFS Sbjct: 366 SKPVSFVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFS 425 Query: 432 TGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGF 478 G R C G+ A E+ ++ L F VDP + + + Sbjct: 426 AGPRNCIGQQFAMNEMKVVTALCLLRFEFS--VDPLRLPIKLPQLVL 470 >3K9V-A nrPDB Length = 482 Score = 289 bits (740), Expect = 2e-78, Method: Composition-based stats. Identities = 103/480 (21%), Positives = 202/480 (42%), Gaps = 45/480 (9%) Query: 34 PGPFPLPIIGNLFQL----ELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEA 89 PGP P++G+L ++ LK + +++G +F + +GS V + ++ EA Sbjct: 27 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSP-SLLEA 85 Query: 90 LLDYKDEFSGRGDLPAFHAHRDR-----GIIFNNGPTWKDIRR-FSLTTLRNYGMGKQGN 143 L + R ++ + A+RD G++ G W+ +R F ++ + K Sbjct: 86 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK--L 143 Query: 144 ESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL-MYL 202 + +I LE + + C I D+ + + N F + + L Sbjct: 144 DKKINEVLADFLERMDEL------------CDERGRIPDL----YSELNKWSFESICLVL 187 Query: 203 FNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCP 262 + + F LL + F + + + + K++ E+ + ++ +V + H Sbjct: 188 YEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIF 247 Query: 263 RDLTDCLLVEMEKEKHSAERLYTMD----------GITVTVADLFFAGTETTSTTLRYGL 312 + + C+ +++ + D + V +L A ETT+ +L + L Sbjct: 248 KSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWIL 307 Query: 313 LILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEA 372 L + P+ + +L +E+ V+ ++ P +D + MPY+ A + E R VP Sbjct: 308 YNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTL 366 Query: 373 TRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFST 432 + T+ Y +PKGTV+ + F D KF+PE +L + K + PF Sbjct: 367 DKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAH-LPFGI 425 Query: 433 GKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492 GKR+C G LA ++L L LC I+Q +++ D + +++ +H+G + PR Sbjct: 426 GKRMCIGRRLAELQLHLALCWIIQKYDIV-ATDNEPVEM--LHLGILVPSRELPIAFRPR 482 >3MDV-A nrPDB Length = 456 Score = 266 bits (681), Expect = 1e-71, Method: Composition-based stats. Identities = 94/451 (20%), Positives = 172/451 (38%), Gaps = 28/451 (6%) Query: 47 QLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALL--DYKDEFSGRGDLP 104 ++ + + F A+++GPV + V + V++ ++VK+ L+ Y + L Sbjct: 6 EVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQ 65 Query: 105 AFHAHR--DRGIIFN-NGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALR-K 160 R +G++ N W RR + +A L+E L K Sbjct: 66 TVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLV--SLMETFNEKAEQLVEILEAK 123 Query: 161 TQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNN 220 GQ P + + DIL + F L ++ L+ N Sbjct: 124 ADGQT--PVSMQDMLTYTAM-DILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNT 180 Query: 221 FPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLD--PNCPRDLTDCLLVEMEKEKH 278 FL R+V +++ +++ + V+ ++L P D+ +L E + Sbjct: 181 LAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQ- 239 Query: 279 SAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRI 338 +G+ F AG ET++ L + ++ L + PEI +L E+D VIG R Sbjct: 240 ------DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY 293 Query: 339 PAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLY 398 +D + Y+ V+ E R +T+ G +P T ++ + + Sbjct: 294 LDFEDLGRLQYLSQVLKESLRLYPPA-WGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGR 352 Query: 399 DNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 + F DP F P+ F G K + PFS G R C G+ A+ME+ +++ +LQ Sbjct: 353 MDTYFEDPLTFNPDRF--GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL 410 Query: 459 NLKPLVD-----PKDIDLSPIHIGFGCIPPR 484 + + + L P+ + PR Sbjct: 411 EFRLVPGQRFGLQEQATLKPLDPVLCTLRPR 441 >6M7X-A nrPDB Length = 484 Score = 255 bits (652), Expect = 3e-68, Method: Composition-based stats. Identities = 98/449 (21%), Positives = 158/449 (35%), Gaps = 47/449 (10%) Query: 22 MWRQVHSSWN-------LPPGPFPLPIIGNLFQL----ELKNIPKSFTRLAQRFGPVFTL 70 M ++ S +P P + L Q+ +++ + Q GP+F Sbjct: 1 MAKKTSSVPRTVLPFEAMPRRPGNRWL--RLLQIWREQGYEDLHLEVHQTFQELGPIFRY 58 Query: 71 YVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDR-----GIIFNNGPTWKDI 125 +G MV + + V E L R L + A+R G+ NGP W+ Sbjct: 59 DLGGAGMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWR-F 116 Query: 126 RRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILF 185 R L Q + A +AL+K Q + + P Sbjct: 117 NRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSI------- 169 Query: 186 RKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEY 245 F Y E + LF E L+ NF L + S +++ + + Sbjct: 170 ---FHYTIEA--SNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRW 224 Query: 246 VSERV-KEHHQSLD------PNCPRDLTDCLLVEMEKEKHS------AERLYTMDGITVT 292 S +V KEH ++ D NC + + L ++ S + D I Sbjct: 225 TSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKAN 284 Query: 293 VADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDA 352 +L +TT L L L + P +++ L +E K E+P + A Sbjct: 285 SMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRA 344 Query: 353 VVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPE 412 + E R V L A+ D + + Y IP GT+V L S+ + FP PE++ P+ Sbjct: 345 ALKETLRLYP-VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQ 403 Query: 413 HFLNENGKFKYSDYFKPFSTGKRVCAGEG 441 +L+ G + Y PF G R C G Sbjct: 404 RWLDIRGS-GRNFYHVPFGFGMRQCLGRR 431 >4ZGX-A nrPDB Length = 489 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 93/432 (21%), Positives = 158/432 (36%), Gaps = 40/432 (9%) Query: 32 LPPGPFPLPIIGNLFQL----ELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVK 87 +P P + L Q+ +++ + Q GP+F +G RMV + + V Sbjct: 18 MPQHPGNRWL--RLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDV- 74 Query: 88 EALLDYKDEFSGRGDLPAFHAHRDR-----GIIFNNGPTWKDIRRFSLTTLRNYGMGKQG 142 E L R L + A+R G+ NGP W+ R L Q Sbjct: 75 EKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWR-FNRLRLNPDVLSPKAVQR 133 Query: 143 NESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYL 202 + A +AL+K Q + + P F Y E + L Sbjct: 134 FLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSI----------FHYTIEA--SNLAL 181 Query: 203 FNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERV-KEHHQSLD--- 258 F E L+ NF L + S +++ + ++S +V KEH ++ D Sbjct: 182 FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIF 241 Query: 259 ---PNCPRDLTDCLLVEMEK------EKHSAERLYTMDGITVTVADLFFAGTETTSTTLR 309 NC + + L + + + +++ I +L +TT+ L Sbjct: 242 QYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLL 301 Query: 310 YGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLP 369 L L + P++++ L +E K E+P + A + E R V L Sbjct: 302 MTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYP-VGLFLE 360 Query: 370 HEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKP 429 + D + + Y IP GT+V L S+ + FP PE++ P+ +L+ G + + P Sbjct: 361 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGS-GRNFHHVP 419 Query: 430 FSTGKRVCAGEG 441 F G R C G Sbjct: 420 FGFGMRQCLGRR 431 >6AYB-A nrPDB Length = 466 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 101/480 (21%), Positives = 187/480 (38%), Gaps = 36/480 (7%) Query: 22 MWRQVHSSWNLPPGPFPL-PIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVM 80 M ++ S LPP L P +G+ KN + ++++G VFT + + M + Sbjct: 1 MAKKTSSKGKLPPRVPNLIPYVGSFVSF-AKNPVQFIIDNSKKYGDVFTATILGKEMTFL 59 Query: 81 HGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFN--NGPTWKDIRRFSLTTLRN--Y 136 + K + +E S R G++++ + + +F + L + Sbjct: 60 NHPKILDTFFKATDNELSLRDVYRFMRPVFGTGVVYDADSTERMMEQVKFVSSGLTTARF 119 Query: 137 GMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKF 196 + E I + L D L+ + L Sbjct: 120 RVFVDIFEDEIAHKVKEL------GPEGTVDVAELMADLIIFTASRCLLGDEVR------ 167 Query: 197 LRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHR-KVIKNVAEV-KEYVSERVKEHH 254 YL +N L + F LP R K K V E+ +E + +R +EH Sbjct: 168 ---QYLSEKNLGKLYHDIDDGISPLSFFYPSLPAPKRDKARKAVGEIFQELLDKRREEHK 224 Query: 255 ---QSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYG 311 + L D+ D LL + K+ + L + I + +A LF AG T+S T + Sbjct: 225 KHPERLLDESKMDVVDHLLTQKYKD---GQELTDVHRIGILIAGLF-AGQHTSSITSSWT 280 Query: 312 LLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHE 371 L+ ++ ++ EK+ +E + ++G ++ +M Y++A + E R + + Sbjct: 281 LMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPL-IMIMRM 339 Query: 372 ATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFS 431 A + Y+IPKG ++V + + +P+ F PE K+ PF Sbjct: 340 ARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGAVPFG 399 Query: 432 TGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPP---RYKLC 488 G+ C GE A +++ ++ +L++F+++ + K D S + G PP RYKL Sbjct: 400 AGRHKCIGENFALLQVKSIISILLRYFDMEYIG--KIPDPSYTSLVVGPSPPTRMRYKLR 457 >3EL3-A nrPDB Length = 467 Score = 241 bits (614), Expect = 6e-64, Method: Composition-based stats. Identities = 97/459 (21%), Positives = 174/459 (37%), Gaps = 31/459 (6%) Query: 38 PLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEF 97 +P++G+ ++L P +F + G V + +G + + + + L+ Sbjct: 30 GVPLLGHGWRLARD--PLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHI 87 Query: 98 SGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEA 157 +G G+ NGP + RR R ++ EAH L E Sbjct: 88 AGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRL--DAIPAYGPIMEEEAHALTE- 144 Query: 158 LRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL----MYLFNENFHLLSTP 213 R G+ D T V A L R Y DE+ RL +F + + P Sbjct: 145 -RWQPGKTVDATSESFRVAVRVAARCLLRGQ--YMDERAERLCVALATVFRGMYRRMVVP 201 Query: 214 WLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEM 273 LY ++R+ +A++ V E + E S D LL + Sbjct: 202 LGPLY-------RLPLPANRRFNDALADLHLLVDEIIAERRASGQKP------DDLLTAL 248 Query: 274 EKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI 333 + K I V + G+ET ++T+ + L L +PE +++ +E++ V Sbjct: 249 LEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVT 308 Query: 334 GPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTL 393 G R A +D +++ + V+ E R V L A ++ GY IP G ++ + Sbjct: 309 G-GRPVAFEDVRKLRHTGNVIVEAMRLRPAV-WVLTRRAVAESELGGYRIPAGADIIYSP 366 Query: 394 DSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCA 453 ++ D + + D +F P+ +L E KPFS GKR C + + +L L+ A Sbjct: 367 YAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAA 426 Query: 454 ILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492 + + + + D + +G P + + R Sbjct: 427 LATKYRFEQVAGSND----AVRVGITLRPHDLLVRPVAR 461 >5FSA-A nrPDB Length = 490 Score = 237 bits (605), Expect = 7e-63, Method: Composition-based stats. Identities = 104/512 (20%), Positives = 189/512 (36%), Gaps = 93/512 (18%) Query: 22 MWRQVHSSWNLPPGPFPL-PIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVM 80 M ++ PP F P G+ + + F Q++G VF+ + + M V Sbjct: 1 MAKKT------PPLVFYWIPWFGSAASYGQQ-PYEFFESCRQKYGDVFSFMLLGKIMTVY 53 Query: 81 HGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGI-IFNNGPTW----------KDIRRFS 129 G K E + + + D+ A A++ +F G + K +F+ Sbjct: 54 LGPKG-HEFVFN-----AKLSDVSAEEAYKHLTTPVFGTGVIYDCPNSRLMEQKKFAKFA 107 Query: 130 LTT-------------LRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAP 176 LTT + NY + +ES +E + + KTQ P I A Sbjct: 108 LTTDSFKRYVPKIREEILNYFVT---DESFKLKEKTHGVANVMKTQ-----PEITIFTAS 159 Query: 177 CNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVI 236 ++ D + R D F +L ++ F TP ++ N P LP R+ Sbjct: 160 RSLFGDEMRRI----FDRSFAQLYSDLDKGF----TPINFVFPNLP-----LPHYWRRDA 206 Query: 237 KNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADL 296 Y+ E +K + D + RDL D LL+ + T I + + Sbjct: 207 AQKKISATYMKE-IKLRRERGDIDPNRDLIDSLLIH---STYKDGVKMTDQEIANLLIGI 262 Query: 297 FFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI----GPSRIPAIKDRQEMPYMDA 352 G T+++T + LL L + P +++ +++E+ ++ G +D Q++P ++ Sbjct: 263 LMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNN 322 Query: 353 VVHEIQRFITLVPSNLPHEATRDTIF--RGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410 + E R + S + + T Y++PKG V+ + + F +PE F Sbjct: 323 TIKETLRMHMPLHS-IFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFD 381 Query: 411 PEHFLNENGKF--------------------KYSDYFKPFSTGKRVCAGEGLARMELFLL 450 P + K S + PF G+ C GE A ++L + Sbjct: 382 PTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTI 441 Query: 451 LCAILQHFNLKPLVDPKDIDLSPIHIGFGCIP 482 L + +NL+ +D + P + +P Sbjct: 442 LTTFV--YNLRWTIDGYKVP-DPDYSSMVVLP 470 >5VWS-A nrPDB Length = 393 Score = 234 bits (598), Expect = 5e-62, Method: Composition-based stats. Identities = 98/405 (24%), Positives = 144/405 (35%), Gaps = 82/405 (20%) Query: 66 PVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDL-PAFHAHRDRGIIFNNGPTWKD 124 PV+ G + + Y V++ L DY+ S R L P GI + P + Sbjct: 32 PVWRDQFG---IYHVFRYDDVRQILGDYQTFSSDRTRLMPTAQGFGKGGITMIDPPEHRH 88 Query: 125 IRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGC-APCNVIADI 183 RR T E RI++ A LL+ L G FD P VIA++ Sbjct: 89 QRRL--ITHAFTPQSISAMEPRIRQIADHLLDEL---PGPEFDLVEHFAYPLPVIVIAEL 143 Query: 184 L---------FRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRK 234 L FR D RLM L EN+ P R Sbjct: 144 LGVPPGDRHLFRTWSD-------RLMSLQVENYA-------------------DPELART 177 Query: 235 VIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVA 294 V + E+ +Y+ E + PRD LL + + + +RL ++ + T + Sbjct: 178 VAAAMTEMNDYLREHCRSRRTH-----PRD---DLLTRLVQAEVEGKRL-DLEEVVNTAS 228 Query: 295 DLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVV 354 L AG TT+ + +L L +PE E+ + + PS IP A + Sbjct: 229 LLLLAGHLTTTVLIGNTMLCLWDHPEAEKAVRAD------PSLIP------------AAL 270 Query: 355 HEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHF 414 E R + TRD G IP V+ + S +D++ FPDPE+F Sbjct: 271 EESLRLRSPF-LQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFDLHRQ 329 Query: 415 LNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFN 459 + F G C G L R+E + L +L F Sbjct: 330 TTGHIA---------FGHGVHFCLGAQLGRLEGRIALERLLGRFT 365 >3JUS-A nrPDB Length = 461 Score = 232 bits (591), Expect = 3e-61, Method: Composition-based stats. Identities = 85/454 (18%), Positives = 171/454 (37%), Gaps = 39/454 (8%) Query: 22 MWRQVHSSW-NLPPGPF-PLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVV 79 M ++ + PP F P+P +G+ K+ + +++GPVF+ + + Sbjct: 1 MAKKTLPAGVKSPPYIFSPIPFLGHAIAFG-KSPIEFLENAYEKYGPVFSFTMVGKTFTY 59 Query: 80 MHGYKAV-------KEALLDYKDEFSGRGDLPAFHAHRDRGIIFN-NGPTWKDIRRFSLT 131 + G A E L ++ R P F +G+ ++ P + + ++ + Sbjct: 60 LLGSDAAALLFNSKNEDL--NAEDVYSRLTTPVF----GKGVAYDVPNPVFLEQKKMLKS 113 Query: 132 TLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDY 191 L + S I++E E+ ++ + + + L K Sbjct: 114 GLNIAHFKQHV--SIIEKETKEYFESWGESGEKNV--FEALSELIILTASHCLHGKEIRS 169 Query: 192 N-DEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERV 250 +EK +L + F + WL P +L LP S R+ + E+K+ + + Sbjct: 170 QLNEKVAQLYADLDGGFSHAA--WL-----LPGWLP-LP-SFRRRDRAHREIKDIFYKAI 220 Query: 251 KEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRY 310 ++ QS ++ D +L + + R T D + + L AG T+STT + Sbjct: 221 QKRRQS------QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAW 274 Query: 311 GLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKD-RQEMPYMDAVVHEIQRFITLVPSNLP 369 L + +++K + E V G + P D +++ +D + E R + + Sbjct: 275 MGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMM- 333 Query: 370 HEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKP 429 A GY IP G V + + + F P+ +L +N + P Sbjct: 334 RMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVP 393 Query: 430 FSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL 463 F G+ C GE A +++ + +L+ + + Sbjct: 394 FGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLI 427 >2WX2-A nrPDB Length = 473 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 87/453 (19%), Positives = 164/453 (36%), Gaps = 30/453 (6%) Query: 33 PPGPFPLPIIGNLFQLELKNIPKSFTRLAQ--RFGPVFTLYVGSQRMVVMHGYKAVKEAL 90 P P +P +G++ Q KN + R + + G VFT+ +G QR+ ++ Sbjct: 19 PVYPVTVPFLGHIVQFG-KNPLEFMQRCKRDLKSG-VFTISIGGQRVTIVGDPHEHSRFF 76 Query: 91 LDYKDEFSGRGDLPAFHAHRDRGIIFNN-GPTWKDIRRFSLTTLRNYGMGKQGNESRIQR 149 + S R G+ + P ++ F L Q IQ Sbjct: 77 SPRNEILSPREVYTIMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKF--QNFVPAIQH 134 Query: 150 EAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHL 209 E + K + G N LF D + F + Sbjct: 135 EVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFG-----EDLRKRLNARHFAQLLSK 189 Query: 210 LSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERV--KEHHQSLDPNCPRDLTD 267 + + + P L + + AE+++ + E + +E ++ N DL Sbjct: 190 MESSLIPAAVFMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNTSDLLG 249 Query: 268 CLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMK--YPEIEEKL 325 LL + ++ ++ + + FAG T++ T + +L LM + +KL Sbjct: 250 GLLKAVYRD----GTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKL 305 Query: 326 HEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPK 385 H+EID P+++ EMP+ + V E R + + + Y++PK Sbjct: 306 HKEIDEF--PAQLNYDNVMDEMPFAERCVRESIRRDPPL-LMVMRMVKAEVKVGSYVVPK 362 Query: 386 GTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARM 445 G ++ + +D + FP+P + PE +G F F G C G+ A + Sbjct: 363 GDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGA------FIGFGAGVHKCIGQKFALL 416 Query: 446 ELFLLLCAILQHFNLKPLVD-PKDIDLSPIHIG 477 ++ +L + ++ + L D D D + +G Sbjct: 417 QVKTILATAFREYDFQLLRDEVPDPDYHTMVVG 449 >3S79-A nrPDB Length = 503 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 95/432 (21%), Positives = 184/432 (42%), Gaps = 34/432 (7%) Query: 40 PII--GNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD--YKD 95 P+I G + + + + R +G +++ + +++ ++ + Y Sbjct: 58 PLISHGRFLWMGIGSACNYYNR---VYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSS 114 Query: 96 EFSGRGDLPAFHAHRDRGIIFNNGPT-WKDIRRFSLTTLRNYGMGKQGNESRIQREAH-F 153 F + L H ++GIIFNN P WK R F + L G+ + + H Sbjct: 115 RFGSKLGLQCIGMH-EKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLD 173 Query: 154 LLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTP 213 LE + G +V+ +L R D ++ FLR+ + + Sbjct: 174 RLEEVTNESGY------------VDVLT-LLRRVMLDTSNTLFLRIPLDESAIVVKIQGY 220 Query: 214 WL--QLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLV 271 + Q P + ++K K+V ++K+ + + E + + + L +C+ Sbjct: 221 FDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRI--STEEKLEECMDF 278 Query: 272 EMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDR 331 E T + + + ++ A +T S +L + L ++ K+P +EE + +EI Sbjct: 279 ATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQT 338 Query: 332 VIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVP 391 VIG R I D Q++ M+ ++E R+ +V + +A D + GY + KGT ++ Sbjct: 339 VIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDLVM-RKALEDDVIDGYPVKKGTNIIL 396 Query: 392 TLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLL 451 + + + FP P +F E+F K YF+PF G R CAG+ +A + + +L Sbjct: 397 NIGRMHR-LEFFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAIL 451 Query: 452 CAILQHFNLKPL 463 +L+ F++K L Sbjct: 452 VTLLRRFHVKTL 463 >3L4D-A nrPDB Length = 453 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 82/460 (17%), Positives = 164/460 (35%), Gaps = 36/460 (7%) Query: 29 SWNLPP---GPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKA 85 LPP G P +G++ Q K+ + +++G +FT+ + R+ V+ Sbjct: 1 KGKLPPVVHGTT--PFVGHIIQFG-KDPLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQ 57 Query: 86 VKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNN-GPTWKDIRRFSLTTLRNYGMGKQGNE 144 + + S R G+ + P ++ F L Q Sbjct: 58 HSKFFTPRNEILSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTVAKF--QNFA 115 Query: 145 SRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRK--HFDYNDEKFLRLMYL 202 IQ E ++A + N LF + + +F +L+ Sbjct: 116 PSIQHEVRKFMKANWNKDEGEINILDDCSAMIINTACQCLFGEDLRKRLDARQFAQLLAK 175 Query: 203 FNENFHLLSTPWLQLYNNFPSFLHYLPGSHR-KVIKNVAEVKEYVSERV--KEHHQSLDP 259 F ++ LP + AE+++ +SE + +E ++ Sbjct: 176 MESCLI--------PAAVFLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEEAQKD 227 Query: 260 NCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILM--K 317 DL LL + ++ + + + FAG T++ T + LL LM + Sbjct: 228 TNTSDLLAGLLGAVYRD----GTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPR 283 Query: 318 YPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTI 377 KLH+EID P+++ +EMP+ + E R + L + + Sbjct: 284 NKRHLAKLHQEIDEF--PAQLNYDNVMEEMPFAEQCARESIRRDPPL-VMLMRKVLKPVQ 340 Query: 378 FRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVC 437 Y++P+G ++ + D + FP+P ++ PE + F F G C Sbjct: 341 VGKYVVPEGDIIACSPLLSHQDEEAFPNPREWNPERNMK-----LVDGAFCGFGAGVHKC 395 Query: 438 AGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIG 477 GE +++ +L +L+ ++ + L + + + +G Sbjct: 396 IGEKFGLLQVKTVLATVLRDYDFELLGPLPEPNYHTMVVG 435 >5JLC-A nrPDB Length = 515 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 92/506 (18%), Positives = 181/506 (35%), Gaps = 57/506 (11%) Query: 3 ALGVT--VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPL-PIIGNLFQLELKNIPKSFTR 59 AL + V+++V F+ ++ + PP F P +G+ K + F Sbjct: 6 ALPLAQRVSIMVALPFVYTITWQLLYSLRKDRPPLVFYWIPWVGSAIPYGTK-PYEFFED 64 Query: 60 LAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGI-IFNN 118 +++G +F+ + + M V G K E + + K D+ A A+ +F Sbjct: 65 CQKKYGDIFSFMLLGRIMTVYLGPKG-HEFIFNAKLA-----DVSAEAAYSHLTTPVFGK 118 Query: 119 GPTWK--DIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFD------PTF 170 G + + R + K+ + A + + R ++ + Sbjct: 119 GVIYDCPNHRLMEQKKFVKGALTKEAFVRYVPLIAEEIYKYFRNSKNFKINENNSGIVDV 178 Query: 171 LIGCAPCNVIA---DILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHY 227 ++ + +L ++ D D F L ++ F TP ++ N P Sbjct: 179 MVSQPEMTIFTASRSLLGKEMRDKLDTDFAYLYSDLDKGF----TPINFVFPNLPL---- 230 Query: 228 LPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMD 287 +RK + +KE + D RDL D L M+ + T Sbjct: 231 --EHYRKRDHAQQAISGTYMSLIKERREKNDIQN-RDLIDEL---MKNSTYKDGTKMTDQ 284 Query: 288 GITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPS-RIPAIKDRQE 346 I + + G T++ T + LL L + P+++E+L++E RV+ + D Q Sbjct: 285 EIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQEQMRVLNNDTKELTYDDLQN 344 Query: 347 MPYMDAVVHEIQRFITLVPSNLPHEATRDTIF--RGYLIPKGTVVVPTLDSVLYDNQEFP 404 MP ++ ++ E R + S L + RD Y++P+ V+ + + FP Sbjct: 345 MPLLNQMIKETLRLHHPLHS-LFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFP 403 Query: 405 DPEKFKPEHFLNENGKF-----------------KYSDYFKPFSTGKRVCAGEGLARMEL 447 P +F + + S + PF G+ C GE A +L Sbjct: 404 KPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQL 463 Query: 448 FLLLCAILQHFNLKPLVDPKDIDLSP 473 +L+ ++ + + + + S Sbjct: 464 GVLMSIFIRTMKWRYPTEGETVPPSD 489 >4WMZ-A nrPDB Length = 539 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 96/479 (20%), Positives = 172/479 (35%), Gaps = 70/479 (14%) Query: 33 PPGPFPL-PIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALL 91 PP F P +G+ +K + F +++G +F+ + + M V G K E + Sbjct: 56 PPLVFYWIPWVGSAVVYGMK-PYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKG-HEFVF 113 Query: 92 DYKDEFSGRGDLPAFHAHRDRGI-IFNNGPTWK-------DIRRFSLTTLRNYGMGKQGN 143 + K D+ A A+ +F G + + ++F L + Sbjct: 114 NAKLA-----DVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALT--KEAFKSY 166 Query: 144 ESRIQREAHFLLE-----ALRKTQGQPFD-----PTFLIGCAPCNVIADILFRKHFDYND 193 I E + L + D P I A +++ + K D Sbjct: 167 VPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKL----D 222 Query: 194 EKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEH 253 F L ++ F TP ++ N P +RK + +KE Sbjct: 223 TDFAYLYSDLDKGF----TPINFVFPNLPL------EHYRKRDHAQKAISGTYMSLIKER 272 Query: 254 HQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLL 313 ++ D RDL D L M+ + T I + + G T++ T + LL Sbjct: 273 RKNNDIQ-DRDLIDSL---MKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILL 328 Query: 314 ILMKYPEIEEKLHEEIDRVI-GPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEA 372 L + P+++++L+EE RV+ G + QEMP ++ + E R + S L + Sbjct: 329 HLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHS-LFRKV 387 Query: 373 TRDTIF--RGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKF--------- 421 +D Y+IP G V+ + ++ FP+ +F + N++ Sbjct: 388 MKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDY 447 Query: 422 -------KYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQ----HFNLKPLVDPKDI 469 S + PF G+ C GE A +L +L+ ++ H+ V P D Sbjct: 448 GFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDF 506 >6CR2-A nrPDB Length = 477 Score = 215 bits (548), Expect = 3e-56, Method: Composition-based stats. Identities = 95/488 (19%), Positives = 165/488 (33%), Gaps = 61/488 (12%) Query: 22 MWRQVHSSWNLPPGPFPL-PIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVM 80 M ++ PP F P IG+ + + K F ++G +FT + ++ V Sbjct: 1 MAKKT------PPVVFHWFPFIGSTISYGI-DPYKFFFDCRAKYGDIFTFILLGKKTTVY 53 Query: 81 HGYKAVKEALLDY-----KDEFSGRGDLPAFHAHRDRGIIFNNGPTWK--DIRRFSLTTL 133 G K L +E P F H + + P K + ++F L Sbjct: 54 LGTKGNDFILNGKLRDVCAEEVYSPLTTPVFGRH-----VVYDCPNAKLMEQKKFVKYGL 108 Query: 134 RNYGMGKQGNESRIQREAHFLLEALRKTQG--QPFDPTFLIGCAPCNVIADILFRKHFDY 191 + I E ++ QG FD I + L K Sbjct: 109 T--SDALRSYVPLITDEVESFVKNSPAFQGHKGVFDVCKTIAEITIYTASRSLQGKEVRS 166 Query: 192 N-DEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSH-RKVIKNVAEVKEYVSER 249 D F L + + F ++ L + P H RK ++ E E Sbjct: 167 KFDSTFAELYHNLDMGFAPINF-----------MLPWAPLPHNRKRDAAQRKLTETYMEI 215 Query: 250 VKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLR 309 +K Q+ D+ L+ + K + I + L AG ++S+T Sbjct: 216 IKARRQAGSKKDSEDMVWNLMSCVYKN----GTPVPDEEIAHMMIALLMAGQHSSSSTAS 271 Query: 310 YGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKD-RQEMPYMDAVVHEIQRFITLVPSNL 368 + +L L P+I E+L++E RV+G P D Q++ V+ E R + S + Sbjct: 272 WIVLRLATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPIHSII 331 Query: 369 PHEATRDTIFRG--YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHF---------LNE 417 G Y+IP V+ + + FP+P ++ P + +E Sbjct: 332 -RAVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDE 390 Query: 418 NGKFKYS-------DYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDID 470 + Y + PF G+ C GE A ++L + +++ F + L I Sbjct: 391 KVDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPGVDGIP 450 Query: 471 LSPIHIGF 478 + F Sbjct: 451 DTDYSSLF 458 >2VE3-A nrPDB Length = 444 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 91/435 (20%), Positives = 161/435 (37%), Gaps = 29/435 (6%) Query: 32 LPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALL 91 +PPG F LP +G + Q+FGP+F + + ++ + G A + Sbjct: 13 IPPGDFGLPWLGETLNFLNDG--DFGKKRQQQFGPIFKTRLFGKNVIFISGALANRFLFT 70 Query: 92 DYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREA 151 ++ F L + G + R+ + ++ Sbjct: 71 KEQETFQATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFLPRTL--DSYLPKMDGIV 128 Query: 152 HFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLS 211 LE K + +V A + + N + F F L Sbjct: 129 QGYLEQWGKAN--EVIWYPQLRRMTFDVAATLFMGEKVSQNPQLFPWFETYIQGLFSL-- 184 Query: 212 TPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLV 271 P F S R +AE+++ + R ++ P D LL Sbjct: 185 -PIPLPNTLFG-------KSQRARALLLAELEKIIKARQQQ------PPSEEDALGILLA 230 Query: 272 EMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDR 331 + + ++ + + L FAG ET ++ L L+L ++ +I E++ +E ++ Sbjct: 231 ARD----DNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQNK 286 Query: 332 VIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVP 391 + S+ + ++MPY+D V+ E+ R I V E +D F+G+ PKG +V Sbjct: 287 LQL-SQELTAETLKKMPYLDQVLQEVLRLIPPVGGGF-RELIQDCQFQGFHFPKGWLVSY 344 Query: 392 TLDSVLYDNQEFPDPEKFKPEHF-LNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLL 450 + D +PDPEKF PE F + + PF G R C G+ AR+E+ L Sbjct: 345 QISQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKLF 404 Query: 451 LCAILQHFNLKPLVD 465 ++Q F+ L Sbjct: 405 ATRLIQQFDWTLLPG 419 >3MZS-A nrPDB Length = 486 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 82/441 (18%), Positives = 163/441 (36%), Gaps = 22/441 (4%) Query: 34 PGPFPLPIIGNLF-QLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD 92 PG + + + + + I Q++GP++ +G+ V + + V L Sbjct: 16 PGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAH-LFK 74 Query: 93 YKDEFSGRGDLPAFHAHRDR-----GIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRI 147 ++ + R D+P + A+ G++F TWK R L T + + Sbjct: 75 FEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDR-VVLNTEVMAPEAIKNFIPLL 133 Query: 148 QREAHFLLEALRKT-----QGQPF-DPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMY 201 + + L K G+ D + I +++F + +E Sbjct: 134 NPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQ 193 Query: 202 LFNENFHLLSTPWLQLYNNFPSFLHYLP-GSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 260 F + + + + L N P + R + + + + +Q L Sbjct: 194 KFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRK 253 Query: 261 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 320 +L + K ++ + + ++ G TTS TL++ L + + Sbjct: 254 TEFRNYPGILYCLLK-----SEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLN 308 Query: 321 IEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRG 380 ++E L EE+ + K Q +P + A + E R + L D + + Sbjct: 309 VQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPI-SVTLQRYPESDLVLQD 367 Query: 381 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 440 YLIP T+V + ++ D F P+KF P +L+++ + F G R C G Sbjct: 368 YLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRN-LGFGWGVRQCVGR 426 Query: 441 GLARMELFLLLCAILQHFNLK 461 +A +E+ L L IL++F ++ Sbjct: 427 RIAELEMTLFLIHILENFKVE 447 >2W0A-A nrPDB Length = 455 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 72/424 (16%), Positives = 150/424 (35%), Gaps = 20/424 (4%) Query: 46 FQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPA 105 + + R+ G V T + +++V++ G A E D+ + Sbjct: 19 LEEFRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHA-NEFFFRAGDDDLDQAKAYP 77 Query: 106 FHAHR-DRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQ 164 F ++F+ P + K + + + + + Sbjct: 78 FMTPIFGEAVVFDASPE--RRKEMLHNAALRGEQMKGHAATIEDQVRRMIAD---WGEAG 132 Query: 165 PFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSF 224 D + L K F D+ R L++E + P + P Sbjct: 133 EIDLLDFFAELTIYTSSACLIGKKF--RDQLDGRFAKLYHE-LERGTDPLAYVDPYLP-- 187 Query: 225 LHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLY 284 + VA V + ++ R+ RD+ D L+ + + + Sbjct: 188 IESFRRRDEARNGLVALVADIMNGRIAN---PPTDKSDRDMLDVLIA---VKAETGTPRF 241 Query: 285 TMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDR 344 + D IT + FAG T+S T + L+ LM++ + + +E+D + G R + Sbjct: 242 SADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHAL 301 Query: 345 QEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFP 404 +++P ++ V+ E R + L A + +G+ I +G +V + ++FP Sbjct: 302 RQIPQLENVLKETLRLHPPL-IILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP 360 Query: 405 DPEKFKPEHFLNENGKFKYSDY-FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL 463 DP F P + + + + + PF G+ C G A M++ + +L+ + + Sbjct: 361 DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA 420 Query: 464 VDPK 467 P+ Sbjct: 421 QPPE 424 >3EJB-B nrPDB Length = 404 Score = 209 bits (531), Expect = 3e-54, Method: Composition-based stats. Identities = 89/426 (20%), Positives = 143/426 (33%), Gaps = 75/426 (17%) Query: 50 LKNIPKSFTRLAQRFGPVFTLYVGSQ---RMVVMHGYKAVKEALLDYKDEFSGRGDLP-A 105 LKN + L V +Y GS + GY+ + A + F R LP + Sbjct: 12 LKNPYSFYDTLRA----VHPIYKGSFLKYPGWYVTGYE--ETAAILKDARFKVRTPLPES 65 Query: 106 FHAHRDRG------IIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALR 159 ++D ++F N P + +R + + + I H LL+ ++ Sbjct: 66 STKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFT--PRTTESYQPYIIETVHHLLDQVQ 123 Query: 160 KTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYN 219 + + VIA+I+ D E + +Q + Sbjct: 124 GKKKMEV-ISDFAFPLASFVIANIIGVPEED-------------REQLKEWAASLIQTID 169 Query: 220 NFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHS 279 F L + ++ +A KE + +R K H +D+ LL EK+K Sbjct: 170 -FTRSRKALTEGNIMAVQAMAYFKELIQKR-KRH-------PQQDMISMLLKGREKDK-- 218 Query: 280 AERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIP 339 T + T L AG ETT + +L L+++PE KL E D Sbjct: 219 ----LTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPD--------- 265 Query: 340 AIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYD 399 + V E R+ + A+ D G I +G V L + D Sbjct: 266 ---------LIGTAVEECLRYESPTQMT-ARVASEDIDICGVTIRQGEQVYLLLGAANRD 315 Query: 400 NQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFN 459 F +P+ F N + F G VC G LAR+E + + +LQ Sbjct: 316 PSIFTNPDVFDITRSPNPHLS---------FGHGHHVCLGSSLARLEAQIAINTLLQRMP 366 Query: 460 LKPLVD 465 L D Sbjct: 367 SLNLAD 372 >3N9Z-A nrPDB Length = 487 Score = 208 bits (529), Expect = 5e-54, Method: Composition-based stats. Identities = 70/442 (15%), Positives = 158/442 (35%), Gaps = 23/442 (5%) Query: 34 PGPFPLPIIGNLF-QLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD 92 PG + + + + + + Q++GP++ +G+ V + + V L Sbjct: 14 PGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVA-LLFK 72 Query: 93 YKDEFSGRGDLPAFHAHRDR-----GIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRI 147 + R +P + A+ G++ WK R +L + + Sbjct: 73 SEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDR-VALNQEVMAPEATKNFLPLL 131 Query: 148 QREAHFLLEALRK------TQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMY 201 + + L + + D + + I +++F + +E Sbjct: 132 DAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQ 191 Query: 202 LFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHH--QSLDP 259 F + + + + + N P K +V ++ ++ + Sbjct: 192 RFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQK 251 Query: 260 NCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYP 319 +L + + + + I V ++ G +TTS TL++ L + + Sbjct: 252 GSVHHDYRGILYRLL-----GDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNL 306 Query: 320 EIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFR 379 ++++ L E+ ++ Q +P + A + E R + L D + R Sbjct: 307 KVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPI-SVTLQRYLVNDLVLR 365 Query: 380 GYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAG 439 Y+IP T+V + ++ + F DPE F P +L+++ Y F G R C G Sbjct: 366 DYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRN-LGFGWGVRQCLG 424 Query: 440 EGLARMELFLLLCAILQHFNLK 461 +A +E+ + L +L++F ++ Sbjct: 425 RRIAELEMTIFLINMLENFRVE 446 >6CVC-A nrPDB Length = 433 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 77/414 (18%), Positives = 134/414 (32%), Gaps = 64/414 (15%) Query: 79 VMHGYKAVKEALLDYKDEFSGRGDL-----PAFHAHRDRGIIFNNGPTWKDIRRFSLTTL 133 + + + + + F ++ A +I + P + +R Sbjct: 75 ALTKHDDIH-FASRHPEIFHSSPNIVIHDQTPELAEYFGSMIVLDDPRHQRLRSIVSRAF 133 Query: 134 RNYGMGKQGNESRIQREAHFLLEALRKTQ--GQPFDPTFLIGCAPCNVIADILFRKHFDY 191 + + E+ ++ AH L+ A+ + GQ + L G P +I D++ D+ Sbjct: 134 TPKVVAR--IEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMMGIPEEDH 191 Query: 192 NDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVK 251 +F+ +L L +F FL +R Sbjct: 192 E--------QIFHWTNVILGFGDPDLTTDFDEFLQVSMAIG-------GYATALADDRRV 236 Query: 252 EHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYG 311 HH DLT L+ + + ERL + + I + L AG ETT + +G Sbjct: 237 NHHG--------DLTTSLV----EAEVDGERLSSSE-IAMFFILLVVAGNETTRNAISHG 283 Query: 312 LLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHE 371 +L L +YP+ K + D V EI R+ + V + Sbjct: 284 MLALSRYPDERAKWWSDFDG-----------------LAATAVEEIVRWASPV-VYMRRT 325 Query: 372 ATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFS 431 ++D RG + G V S D ++F DP F N F Sbjct: 326 LSQDVDLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQVGFG--------G 377 Query: 432 TGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRY 485 G C G LAR E+ ++ + + + LS G +P + Sbjct: 378 GGAHFCLGANLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKRLPVAW 431 >2X2N-A nrPDB Length = 475 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 81/467 (17%), Positives = 161/467 (34%), Gaps = 30/467 (6%) Query: 33 PPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGP-VFTLYVGSQRMVVMHGYKAVKEALL 91 P P +PI+G++ Q K+ ++ +FT+ + +R+ ++ L Sbjct: 19 PVYPVTVPILGHIIQFG-KSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHSRFFL 77 Query: 92 DYKDEFSGRGDLPAFHAHRDRGIIFNN-GPTWKDIRRFSLTTLRNYGMGKQGNESRIQRE 150 + S R G+ + P ++ F L Q IQ E Sbjct: 78 PRNEVLSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTIAKF--QNFVPAIQHE 135 Query: 151 AHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLL 210 + A + N LF D + F + + Sbjct: 136 VRKFMAANWDKDEGEINLLEDCSTMIINTACQCLFG-----EDLRKRLDARRFAQLLAKM 190 Query: 211 STPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSL--DPNCPRDLTDC 268 + + P L + + E+++ +SE + + + DL Sbjct: 191 ESSLIPAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKAAAVNKDSSTSDLLSG 250 Query: 269 LLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYP---EIEEKL 325 LL + ++ ++ + + FAG T+S T + +L LM +P + E L Sbjct: 251 LLSAVYRD----GTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLM-HPANVKHLEAL 305 Query: 326 HEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPK 385 +EI+ P+++ EMP+ + E R + L + D Y++PK Sbjct: 306 RKEIEEF--PAQLNYNNVMDEMPFAERCARESIRRDPPL-LMLMRKVMADVKVGSYVVPK 362 Query: 386 GTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARM 445 G ++ + +D + FP+P ++ PE G F F G C G+ + Sbjct: 363 GDIIACSPLLSHHDEEAFPEPRRWDPERDEKVEGA------FIGFGAGVHKCIGQKFGLL 416 Query: 446 ELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492 ++ +L + ++ + L D + D + G + ++ I R Sbjct: 417 QVKTILATAFRSYDFQLLRD-EVPDPDYHTMVVGPTASQCRVKYIRR 462 >5L94-A nrPDB Length = 410 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 81/401 (20%), Positives = 134/401 (33%), Gaps = 60/401 (14%) Query: 80 MHGYKAVKEALLDYKDEFSGRGDLPAFHAHR-DRGIIFNNGPTWKDIRRFSLTTLRNYGM 138 + Y VKE L S R +I + P ++R M Sbjct: 49 VFHYDGVKEVLEQKNIFSSDRRPPQNQRQTALGTSLINIDPPKHAEMRALVNKAFTPKAM 108 Query: 139 GKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGC-APCNVIADILFRKHFDYNDEKFL 197 + E +I R + LL+ + + D + P VIADIL D Sbjct: 109 --KAWEPKIARITNELLQEVE--HLEDIDIVEHLSYPLPVMVIADILGVPIEDQR----- 159 Query: 198 RLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSL 257 + + +++ P L ++ +K E++ Y ++E Sbjct: 160 ---QFKDWSDIIVAGPSNNE-------RETLEKLQQEKMKANDELETYFYRIIEEKRTR- 208 Query: 258 DPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMK 317 D+ LL E+ K T + I L AG ETT+ + + LM+ Sbjct: 209 ---PGDDIISVLLQAKEEGKQ-----LTDEEIVGFSILLLIAGNETTTNLISNTIYCLME 260 Query: 318 YPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTI 377 E+L E + + + + E+ R+ + V + L D Sbjct: 261 DKASFERLKREKE------------------LLPSGIEEVLRYRSPVQA-LHRIVKEDVT 301 Query: 378 FRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVC 437 G + G VVP + S D + F DPE FK + N + F G C Sbjct: 302 LAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDRKPNVH---------MAFGRGIHFC 352 Query: 438 AGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGF 478 G LAR+E ++L ++ + + +L PI F Sbjct: 353 LGAPLARIEAKIMLAELIDRYP--QMDWSPSFELKPIESTF 391 >4KPA-A nrPDB Length = 494 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 91/436 (20%), Positives = 169/436 (38%), Gaps = 25/436 (5%) Query: 34 PGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDY 93 P P + NL L ++ ++A G +F + + + +KEA + Sbjct: 30 PQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDES 89 Query: 94 KDEFSGRGDLPAFHAHRDRGIIFN--NGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREA 151 + + + L G+ + + WK L + M +G + + A Sbjct: 90 RFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAM--KGYHAMMVDIA 147 Query: 152 HFLLEALRKTQGQP-FDPTFLIGCAPCNVIADILFRKHFD--YNDEKFLRLMYLFNENFH 208 L++ + + + + I F F+ Y D+ + + Sbjct: 148 VQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSM----VR 203 Query: 209 LLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDC 268 L +L P Y R+ +++ + + V + + + S + +D Sbjct: 204 ALDEAMNKLQRANPDDPAYDENK-RQFQEDIKVMNDLVDKIIADRKAS------GEQSDD 256 Query: 269 LLVEMEKEKH-SAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHE 327 LL M K + I + AG ETTS L + L L+K P + +K E Sbjct: 257 LLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAE 316 Query: 328 EIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRG-YLIPKG 386 E RV+ +P+ K +++ Y+ V++E R P+ A DT+ G Y + KG Sbjct: 317 EAARVLVDP-VPSYKQVKQLKYVGMVLNEALRLWPTAPA-FSLYAKEDTVLGGEYPLEKG 374 Query: 387 TVVVPTLDSVLYDNQEF-PDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARM 445 ++ + + D + D E+F+PE F N + ++ FKPF G+R C G+ A Sbjct: 375 DELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQH--AFKPFGNGQRACIGQQFALH 432 Query: 446 ELFLLLCAILQHFNLK 461 E L+L +L+HF+ + Sbjct: 433 EATLVLGMMLKHFDFE 448 >5Y1I-A nrPDB Length = 403 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 84/430 (19%), Positives = 142/430 (33%), Gaps = 76/430 (17%) Query: 69 TLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPA-------FHAHRDRGIIFNNGPT 121 ++ GS VV + + L D + G D F + + P Sbjct: 37 RIWDGSTPWVV-TRHADQRALLSDPRVSHDGLRDGYPHISADFKFLSMAQPSFAGQDDPE 95 Query: 122 WKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIG-CAPCNVI 180 IRR TL + IQ+ L++ + +P D + P VI Sbjct: 96 HGRIRRMV--TLPFTARRIEAMRPAIQKITDELIDGMLAGP-KPVDLVEALALPVPVRVI 152 Query: 181 ADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKV-IKNV 239 ++L Y D +FL Q NN + G +K I Sbjct: 153 CEMLGVP---YEDREFL------------------QQNNNAMIYRDTAQGDAQKAAIAQA 191 Query: 240 AEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFA 299 +KE V ++ D D +L ++ + + E T D L A Sbjct: 192 MYLKELVGTKL------------GDRGDDILSDLAVQVEAGE--ITQDDAAGIGMMLLGA 237 Query: 300 GTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQR 359 G ETT+ + G L L++ PE ++ D + + V E+ R Sbjct: 238 GHETTANMIALGTLALLENPEQLAEVR----------------DSDDPKVIVNTVEELLR 281 Query: 360 FITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPD-PEKFKPEHFLNEN 418 ++T+ + A D G +I G +V L++ +D +P+ P++ Sbjct: 282 YLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDIHR----- 336 Query: 419 GKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDP-KDIDLSPIHIG 477 + F G C G LAR+EL ++ +L+ L +I I Sbjct: 337 ---ANARRHLAFGYGVHQCLGATLARVELQIVYSTLLRRIPTLALAGTLDEIPFKHDQIA 393 Query: 478 FGC--IPPRY 485 G +P + Sbjct: 394 HGVYELPVTW 403 >2WM5-A nrPDB Length = 435 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 80/414 (19%), Positives = 137/414 (33%), Gaps = 64/414 (15%) Query: 79 VMHGYKAVKEALLDYKDEFSGRGDLP-----AFHAHRDRGIIFNNGPTWKDIRRFSLTTL 133 + Y V A + D FS ++ A +I + P + +R Sbjct: 78 ALTKYDDVFYA-SRHPDIFSSYPNITINDQTPELAEYFGSMIVLDDPRHQRLRSIVSRAF 136 Query: 134 RNYGMGKQGNESRIQREAHFLLEALRKT--QGQPFDPTFLIGCAPCNVIADILFRKHFDY 191 + + E+ ++ AH L+ ++ Q + L G P +I D++ D+ Sbjct: 137 TPKVVAR--IEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKADH 194 Query: 192 NDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVK 251 +F+ +L L +F F+ A++ Y + + Sbjct: 195 Q--------RIFHWTNVILGFGDPDLATDFDEFMQVS-----------ADIGAYATALAE 235 Query: 252 EHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYG 311 + N DLT L+ + + ERL + + I L AG ETT + +G Sbjct: 236 DRRV----NHHDDLTSSLV----EAEVDGERLSSRE-IASFFILLVVAGNETTRNAITHG 286 Query: 312 LLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHE 371 +L L +YPE ++ + D V EI R+ + V + Sbjct: 287 VLALSRYPEQRDRWWSDFDG-----------------LAPTAVEEIVRWASPV-VYMRRT 328 Query: 372 ATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFS 431 T+D RG + G V S D +F DP F N + F Sbjct: 329 LTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFG--------G 380 Query: 432 TGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRY 485 G C G LAR E+ + + + + LS G +P + Sbjct: 381 GGAHFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTW 434 >2VZM-A nrPDB Length = 436 Score = 201 bits (511), Expect = 6e-52, Method: Composition-based stats. Identities = 79/458 (17%), Positives = 148/458 (32%), Gaps = 71/458 (15%) Query: 37 FPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYV-GSQRMVVMHGYKAVKEALLD--Y 93 P+ +G L Q + ++ RL GP + + ++ GY + L D + Sbjct: 32 PPVLDLGALGQDFAADPYPTYARLRAE-GPAHRVRTPEGNEVWLVVGYDRARAVLADPRF 90 Query: 94 KDEFSGRGDLPAF-HAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAH 152 ++ A + ++ ++ P +R+ + + R+Q Sbjct: 91 SKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRV--ELLRPRVQEIVD 148 Query: 153 FLLEALRKTQ-GQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLS 211 L++A+ G+ L P VI+ + L + F + + Sbjct: 149 GLVDAMLAAPDGRADLMESLAWPLPITVIS-------------ELLGVPEPDRAAFRVWT 195 Query: 212 TPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLV 271 + P + +AE+ Y+S + + LL Sbjct: 196 DAF------------VFPDDPAQAQTAMAEMSGYLSRLIDSKRGQ--------DGEDLLS 235 Query: 272 EMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDR 331 + + T + + L AG ETT + G+ L+ +P+ L + Sbjct: 236 ALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRAD--- 292 Query: 332 VIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVP 391 M +D V E+ R+ V S G +IP G V+ Sbjct: 293 ---------------MTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLV 337 Query: 392 TLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLL 451 L + FPDP +F + F G C G LAR+E + + Sbjct: 338 VLADAHRTPERFPDPHRFDIRRDTAGH---------LAFGHGIHFCIGAPLARLEARIAV 388 Query: 452 CAILQHFNLKPL-VDPKDIDL--SPIHIGFGCIPPRYK 486 A+L+ L V P ++ +P+ G +P R++ Sbjct: 389 RALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR 426 >5CJE-A nrPDB Length = 393 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 79/456 (17%), Positives = 142/456 (31%), Gaps = 75/456 (16%) Query: 42 IGNLFQLE------LKNIPKSFTRLAQRFGPVFTLYVGSQRMV---VMHGYKAVKEALLD 92 +GN+ L ++ + L +R GPV + ++ G++ + AL D Sbjct: 1 MGNVIDLGEYGARFTEDPYPVYAELRER-GPVHWVRTPPPEAFEGWLVVGHEEARAALAD 59 Query: 93 --YKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQRE 150 + + +G ++ + P +R + + RIQ Sbjct: 60 PRLSKDGTKKGLTSLDVELMGPYLLVVDPPEHTRLRSLVARAFTMRRV--EALRPRIQEI 117 Query: 151 AHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLL 210 LL+ + +G+ P VI ++L D + L NE Sbjct: 118 TDGLLDEML-PRGRADLVDSFAYPLPITVICELLGVPDIDRVTFRALS-----NEIVA-- 169 Query: 211 STPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLL 270 P + + Y+ E + + + D LL Sbjct: 170 ------------------PTGGDAELAAYERLAAYLDELIDDKRSTA-------PADDLL 204 Query: 271 VEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEID 330 ++ + + + + + + L AG ETT + G+ L+ +P+ L + Sbjct: 205 GDLIRTRAEDDDRLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRAD-- 262 Query: 331 RVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVV 390 M +D V E+ RF V + A G I +G V+ Sbjct: 263 ----------------MTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPVM 306 Query: 391 PTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLL 450 LD+ D PDP F + F G C G LAR+E + Sbjct: 307 IGLDAAGRDPARHPDPHVFDIHRAPQGH---------LAFGHGIHYCLGAPLARLEARVA 357 Query: 451 LCAILQHFNLKPLVDPKDIDLSPI-HIGFGCIPPRY 485 L ++L+ L P + G +P R+ Sbjct: 358 LRSLLERCPDLALDGPPGARPPGMLIRGVRRLPVRW 393 >2ZBZ-A nrPDB Length = 412 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 78/446 (17%), Positives = 149/446 (33%), Gaps = 76/446 (17%) Query: 52 NIPKSFTRLAQRFGPVFTLYV-GSQRMVVMHGYKAVKEALLDYKDEFSGRGD------LP 104 +P + +L GP+ + + ++ V+ ++A ++ L D S R D P Sbjct: 25 QLPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGD-PRLSSNRTDDNFPATSP 83 Query: 105 AFHAHRDRGIIF--NNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQ 162 AF A R+ F + P RR +++ + E ++ H L+ + Sbjct: 84 AFEAVRESPQAFIGLDPPEHGTRRRMTISEFTVKRIKGMRPE--VEEVVHGFLDEMLAAG 141 Query: 163 GQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFP 222 + P VI +L + D+ E F S +Q + Sbjct: 142 PTADLVSQFALPVPSMVICRLLGVPYADH-------------EFFQDASKRLVQSTD--- 185 Query: 223 SFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAER 282 + + ++ Y+ + + + L+ + ++ + Sbjct: 186 ---------AQSALTARNDLAGYLDGLITQFQT--------EPGAGLVGALVADQLANGE 228 Query: 283 LYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIK 342 + + + T L AG ETT++ ++ L+ +PE L + V G Sbjct: 229 I-DREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSLVPG-------- 279 Query: 343 DRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQE 402 V E+ R++ + AT D G LI G V+ D Sbjct: 280 ----------AVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTV 329 Query: 403 FPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKP 462 + DP+ + + F G C G+ LAR+EL ++L A++ Sbjct: 330 YEDPDALDIHRS---------ARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLR 380 Query: 463 LVDP-KDIDLSP--IHIGFGCIPPRY 485 L P + + L P G +P + Sbjct: 381 LAVPVEQLVLRPGTTIQGVNELPVTW 406 >4RM4-A nrPDB Length = 396 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 91/425 (21%), Positives = 147/425 (34%), Gaps = 80/425 (18%) Query: 36 PFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKD 95 PFP ++ K+ P SF Q V+++++ Y VK+ + D + Sbjct: 26 PFPW------YESMRKDAPVSFDEENQ----VWSVFL----------YDDVKKVVGDK-E 64 Query: 96 EFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLL 155 FS +P + II + P IR M + E RIQ L+ Sbjct: 65 LFSS--CMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTPRVMKQ--WEPRIQEITDELI 120 Query: 156 EALRKTQGQPFDPTFLIGC-APCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPW 214 + + FD P VI+++L K + L+STP Sbjct: 121 QKFQGR--SEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKAWSDL--------LVSTPK 170 Query: 215 LQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEME 274 + +FL + K E+ + + ++E N P +LVE E Sbjct: 171 DKSEEAEKAFLE-------ERDKCEEELAAFFAGIIEEKR-----NKPEQDIISILVEAE 218 Query: 275 KEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIG 334 + + + + L AG ETT+ + + +++ P + E+L Sbjct: 219 E----TGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEEL--------- 265 Query: 335 PSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLD 394 R M V E RF P L A RDT G+LI +G +V+ + Sbjct: 266 ---------RSHPELMPQAVEEALRFRAPAPV-LRRIAKRDTEIGGHLIKEGDMVLAFVA 315 Query: 395 SVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAI 454 S D +F P F N + F G C G LAR+E + L ++ Sbjct: 316 SANRDEAKFDRPHMFDIRRHPNPHIA---------FGHGIHFCLGAPLARLEANIALTSL 366 Query: 455 LQHFN 459 + F Sbjct: 367 ISAFP 371 >4YZR-A nrPDB Length = 405 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 67/368 (18%), Positives = 130/368 (35%), Gaps = 65/368 (17%) Query: 118 NGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPC 177 + P +R + I++ A LL+ + K + P Sbjct: 95 DTPDHTRLRSLVHQAFT--PRTIENLRGSIEQIAEQLLDEMEKEN-KADIMKSFASPLPF 151 Query: 178 NVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIK 237 VI++++ D + Q++ N + + G+ + Sbjct: 152 IVISELMGIPKEDRSQ---------------------FQIWTN--AMVDTSEGNRELTNQ 188 Query: 238 NVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLF 297 + E K+Y+++ + H + + P D L+ ++ + + +L + + + L Sbjct: 189 ALREFKDYIAKLI--HDRRIKPK------DDLISKLVHAEENGSKLSEKE-LYSMLFLLV 239 Query: 298 FAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEI 357 AG ETT L G L L+++ + EKL + + + V E+ Sbjct: 240 VAGLETTVNLLGSGTLALLQHKKECEKLKQ------------------QPEMIATAVEEL 281 Query: 358 QRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNE 417 R+ + V A D ++G+ I +G ++ + S D F +PE N Sbjct: 282 LRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILNINRSPNR 341 Query: 418 NGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF-NLKPLVDPKDIDLSPIHI 476 + F G C G LAR+E + A+L+ F +++ V P DI Sbjct: 342 HIS---------FGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQWRKNVF 392 Query: 477 --GFGCIP 482 G +P Sbjct: 393 LRGLESLP 400 >2Y5N-A nrPDB Length = 417 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 76/394 (19%), Positives = 138/394 (35%), Gaps = 69/394 (17%) Query: 80 MHGYKAVKEALLDYKDEFSG----RGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRN 135 + Y+ V+ L D G R + G++ + P +RR + Sbjct: 66 VTRYEDVRAVLGD-GRFVRGPSMTRDEPRTRPEMVKGGLLSMDPPEHSRLRRLVVKAFTA 124 Query: 136 YGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGC-APCNVIADILFRKHFDYNDE 194 + R + AH L++ + T GQP D + P VI ++L D+ Sbjct: 125 --RRAESLRPRAREIAHELVDQMAAT-GQPADLVAMFARQLPVRVICELLGVPSADH--- 178 Query: 195 KFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHH 254 + F S FL + ++ + + Y+ + + Sbjct: 179 ----------DRFTRWSGA----------FLSTAEVTAEEMQEAAEQAYAYMGDLIDRRR 218 Query: 255 QSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLI 314 ++ TD L+ + + + + L + + L AG E+T+T + + + Sbjct: 219 --------KEPTDDLVSALVQARDQQDSLSEQE-LLDLAIGLLVAGYESTTTQIADFVYL 269 Query: 315 LMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITL-VPSNLPHEAT 373 LM PE+ +L + + V E+ R++ L V + P A Sbjct: 270 LMTRPELRRQL------------------LDRPELIPSAVEELTRWVPLGVGTAFPRYAV 311 Query: 374 RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTG 433 D RG I G V+ + + D +FPD ++ + N++ F G Sbjct: 312 EDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDRTPNQH---------LGFGHG 362 Query: 434 KRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK 467 C G LAR+EL + L +LQ L P+ Sbjct: 363 VHHCLGAPLARVELQVALEVLLQRLPGIRLGIPE 396 >2Z36-A nrPDB Length = 413 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 82/450 (18%), Positives = 149/450 (33%), Gaps = 83/450 (18%) Query: 53 IPKSFTRLAQRFGPVFTLYV--GSQRMVVMHGYKAVKEALLDYKDEFSGRG--------- 101 P ++ RL +R P+ + + G Q V G++ + L D S + Sbjct: 24 PPAAYERLRER-APINKVRLTSGGQAWWV-SGHEEARAVLAD-GRFSSDKRKDGFPLFTL 80 Query: 102 DLPAFHAHRDRGIIFN--NGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALR 159 D R + + +G RR + + RIQ ++ + Sbjct: 81 DAATLQQLRSQPPLMLGMDGAEHSAARRPVIGEFTVKRLA--ALRPRIQDIVDHFIDDML 138 Query: 160 KTQGQPFDPTFLIG-CAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLY 218 T +P D + P VI ++L + D++ F ++ + + Sbjct: 139 ATDQRPVDLVQALSLPVPSLVICELLGVPYTDHD----------FFQSRTTMMVSRTSME 188 Query: 219 NNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKH 278 + + AE++ Y+ + + + P D L + + Sbjct: 189 D---------------RRRAFAELRAYIDDLITRK-----ESEPGDD----LFSRQIARQ 224 Query: 279 SAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRI 338 E G+ L AG ETT+ + G++ L+ +PE + P R Sbjct: 225 RQEGTLDHAGLVSLAFLLLTAGHETTANMISLGVVGLLSHPEQLTVVKA------NPGRT 278 Query: 339 PAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLY 398 P V E+ R+ T+ AT D G I G V+ ++ S + Sbjct: 279 P------------MAVEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANW 326 Query: 399 DNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 D F DP E + + F G C G+ LARMEL ++ + + Sbjct: 327 DPAVFKDPAVLDVER---------GARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRI 377 Query: 459 NLKPLVDP-KDIDLSPIHIGFGC--IPPRY 485 L P +D+ + +G +P + Sbjct: 378 PSLRLAVPMEDVPFKGDSVIYGVHELPVTW 407 >5EX6-C nrPDB Length = 434 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 74/438 (16%), Positives = 137/438 (31%), Gaps = 82/438 (18%) Query: 65 GPVFTLYVGS----QRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFN--- 117 G + + +GS + + G+ V++ L D+ FS R +G+ Sbjct: 62 GELTRVRLGSGADAEHTWLATGHDVVRQVLGDH-TRFSTRRRFDRNDEIGGKGVFRPREL 120 Query: 118 -------NGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTF 170 + P +RR + + + I++ L+ + + Sbjct: 121 VGNLMDYDPPEHTRLRRLLAPGFTHRKIRRMA--PYIEQIVTERLDEMEREGSPADLIEL 178 Query: 171 LIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPG 230 P V+ ++L D FL+L + + Sbjct: 179 FADEVPGPVLCELLGVPRDDR--AMFLQLCHRHLDA----------------------SL 214 Query: 231 SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGIT 290 S R+ Y+ V +D D L+ + E T + + Sbjct: 215 SGRRRAAAGEAFSRYLVTMVARER--------KDPGDGLIGMVVAEHGDT---VTDEELR 263 Query: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350 + AG + S + G+L L++ PE L R ++P Sbjct: 264 GVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAAL------------------RGDVPAA 305 Query: 351 DAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410 + V E+ R++T+ + P A D+ +I G V+ +L + D PD ++ Sbjct: 306 ERAVDELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADRLD 365 Query: 411 PEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK--- 467 + F G C G LAR+EL + A+ + F L DP Sbjct: 366 VTREAVPHVA---------FGHGVHHCLGAALARLELRIAYTALWRRFPDLRLADPDGAT 416 Query: 468 DIDLSPIHIGFGCIPPRY 485 + LS G + + Sbjct: 417 EFRLSTPAYGISRLMVTW 434 >4OQS-A nrPDB Length = 433 Score = 191 bits (484), Expect = 9e-49, Method: Composition-based stats. Identities = 82/439 (18%), Positives = 148/439 (33%), Gaps = 87/439 (19%) Query: 63 RFGPVFTLYV-GSQRMVVMHGYKAVKEALLDYKDEFSGRGD---LPAFHAHRDRGIIFNN 118 + PV + ++ + A + ++D FS R + R G Sbjct: 32 KLPPVSPMRFPDGHIGWLVTSHAAARTVMID--PRFSNRPEHKHPVFSVIPRPGGATKAP 89 Query: 119 GPTWK------DIRRFSLTTLRNYGMGK-QGNESRIQREAHFLLEALRKTQGQPFDPTFL 171 P W + R+ + + + + + E RI + L+A+ K G P D Sbjct: 90 APGWFINMDAPEHTRYRRMLISQFTVRRIKELEPRIVQITEDHLDAMAKA-GPPVDLVQA 148 Query: 172 IG-CAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPG 230 P VI ++L + D+ F E ++++ Sbjct: 149 FALPVPSLVICELLGVSYADH---------AFFQEQTTIMASVD---------------K 184 Query: 231 SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGIT 290 + +V + ++ Y++E V S DL L+ + + T + +T Sbjct: 185 TQDEVTTALGKLTRYIAELVATKRLSPKD----DLLGSLITDTD---------LTDEELT 231 Query: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350 L AG ETT+ L G L+++PE L Sbjct: 232 NIALLLLVAGHETTANMLGLGTFALLQHPEQIAALDS----------------------- 268 Query: 351 DAVVHEIQRFITLVPSNLP-HEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKF 409 V E+ R++++V P A D G +I KG V L +V D + F +P+ Sbjct: 269 PDAVEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDIL 328 Query: 410 KPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDP-KD 468 + + + F G C G+ LAR+E+ + + F L P ++ Sbjct: 329 QLDRVD--------ARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEE 380 Query: 469 IDLSPIHIGFGC--IPPRY 485 I L +G +P + Sbjct: 381 IKLREKSAAYGVWALPVAW 399 >4UBS-A nrPDB Length = 393 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 89/429 (20%), Positives = 151/429 (35%), Gaps = 79/429 (18%) Query: 69 TLYVGSQRMVVMHGYKAVKEALLDYKDEFSGR--GDLPA----FHAHRDRGIIFN--NGP 120 +LY G + + V+ G+ A + ALL + S R PA F A R R + + P Sbjct: 32 SLYDG-RSVWVVTGHAAAR-ALLSDQRLSSDRTLPRFPATTERFEAVRTRRVALLGVDDP 89 Query: 121 TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIG-CAPCNV 179 + RR + + RIQ LL+A+ + QG P + P V Sbjct: 90 EHRTQRRMLVPSFTLKRAA--ALRPRIQETVDGLLDAM-EAQGPPAELVSAFALPLPSMV 146 Query: 180 IADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNV 239 I +L + D++ + +++ LL P + +V Sbjct: 147 ICALLGVPYADHD--------FFESQSRRLLRGPGIA-----------------EVQDAR 181 Query: 240 AEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFA 299 A++ +Y+ + ++ D LL ++ +E+ + + + L A Sbjct: 182 AQLDDYLYALIDRKR--------KEPGDGLLDDLIQEQLNRGTV-DRAELVSLATLLLIA 232 Query: 300 GTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQR 359 G ETT+ + G L+++PE +L E M A V E+ R Sbjct: 233 GHETTANMISLGTFTLLRHPEQLAELRAE------------------PGLMPAAVEELLR 274 Query: 360 FITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENG 419 F+++ L AT D G I VV + D F +P+ Sbjct: 275 FLSIA-DGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHRS----- 328 Query: 420 KFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKD-IDLSP--IHI 476 + + F G C G+ LAR E+ + L + + L P D I P Sbjct: 329 ----ARHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLAAPADEIPFKPGDTIQ 384 Query: 477 GFGCIPPRY 485 G +P + Sbjct: 385 GMLELPVTW 393 >4GGV-A nrPDB Length = 418 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 82/404 (20%), Positives = 136/404 (33%), Gaps = 54/404 (13%) Query: 80 MHGYKAVKEALLDYKDEFSGRGDLPAFHA---HRDRGIIFNNGPTWKDIRRFSLTTLRNY 136 ++GY + L D+ S L + + + P + R+ Sbjct: 58 VYGYPEAMDILNDHDTFTSDLAHLLPVSVDAPLLEGDMSQMDPPRHRKYRQLVSRAFTPR 117 Query: 137 GMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKF 196 + E+R+ LL+A+ L P VIA++L D + F Sbjct: 118 LVADM--ETRVADITRELLDAVDGKPEIEI-AADLAYPLPVIVIAELLGVPAGDRD--LF 172 Query: 197 LRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQS 256 + E F S F R + + + +Y++ V E ++ Sbjct: 173 KKWADDIIEGFSGFS---------FLDTSGQGEQDVRDATERLRPLLDYMAGHVTERRRT 223 Query: 257 LDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILM 316 PR+ LL + + + ERL T + I L G TT+ TL +L L Sbjct: 224 -----PRE---DLLTHLVQAEVDGERL-TDNEIVNVANILLVTGHITTTMTLGNTVLCLD 274 Query: 317 KYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDT 376 PE+ K+ + V G + E R ++ + L +R+ Sbjct: 275 ADPEVAAKVRADRSLVPG------------------AIEEALRVLSP-SAALARGTSREV 315 Query: 377 IFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRV 436 G +IPK +V+ L + D ++F DPE + P N + F G Sbjct: 316 EVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDPTRDPNPH---------FGFGRGIHF 366 Query: 437 CAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGC 480 C G LAR+E + L A+ F + K P G Sbjct: 367 CLGAPLARLEGRVALNALFDRFPVLRTDPAKPPTFFPTPDMIGV 410 >5OFQ-A nrPDB Length = 409 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 79/411 (19%), Positives = 139/411 (33%), Gaps = 65/411 (15%) Query: 80 MHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMG 139 + Y+ VK L FS + + R I+ + P +R Sbjct: 54 VFDYETVKYIL-KNPSLFSSKRAME----ERQESILMMDPPKHTKLRNLVNKAFT--PRA 106 Query: 140 KQGNESRIQREAHFLLEALRKTQGQPFDPTFLI-GCAPCNVIADILFRKHFDYNDEKFLR 198 Q E I+ A +LL+ + + + FD G P VIA++L D Sbjct: 107 IQHLEGHIEEIADYLLDEV--SSKEKFDIVEDFAGPLPIIVIAELLGVPIQDRA------ 158 Query: 199 LMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLD 258 L +++ L+S F + +K + V ++ Y E + E Q Sbjct: 159 LFKKYSD--DLVSGAENNSDEAFAKMM-------QKRNEGVIFLQGYFKEIIAERQQ--- 206 Query: 259 PNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKY 318 N DL LL +H T + + L AG ETT+ + G+ + + Sbjct: 207 -NKQEDLISLLLEAEIDGEH-----LTEEEVLGFCILLLVAGNETTTNLITNGVRYMTED 260 Query: 319 PEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIF 378 +++ ++ +I + +V E R+ + + + A D Sbjct: 261 VDVQNEVRRDIS------------------LVPNLVEETLRYYPPIQA-IGRIAAEDVEL 301 Query: 379 RGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCA 438 I +G V+ S D+ +F P+ F N + F G C Sbjct: 302 GECKIKRGQQVISWAASANRDSAKFEWPDTFVVHRKTNPHVS---------FGFGIHFCL 352 Query: 439 GEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCV 489 G LARME + +L+ + ++ L PI F +Y++ Sbjct: 353 GAPLARMEGKIAFTKLLEKGGFSKV---QNQSLKPIDSPFVFGVKKYEIAF 400 >4OQR-A nrPDB Length = 457 Score = 188 bits (476), Expect = 7e-48, Method: Composition-based stats. Identities = 83/439 (18%), Positives = 147/439 (33%), Gaps = 87/439 (19%) Query: 63 RFGPVFTLYV-GSQRMVVMHGYKAVKEALLDYKDEFSGRGD---LPAFHAHRDRGIIFNN 118 + PV + ++ + A + ++D FS R + R G Sbjct: 71 KLPPVSPMRFPDGHIGWLVTSHAAARTVMID--PRFSNRPEHKHPVFSVIPRPGGATKAP 128 Query: 119 GPTWK------DIRRFSLTTLRNYGMGK-QGNESRIQREAHFLLEALRKTQGQPFDPTFL 171 P W + R+ + + + + + E RI R L+A+ K G P D Sbjct: 129 APGWFTNMDAPEHTRYRRMLISQFTVRRIKELEPRIVRITEDHLDAMAKA-GPPVDLVQA 187 Query: 172 IG-CAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPG 230 P VI ++L + D+ F E ++ + Sbjct: 188 FALPVPSLVICELLGVSYADH---------AFFQEQTTIMVSVD---------------K 223 Query: 231 SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGIT 290 + +V + ++ Y++E V S DL L+ + + T + +T Sbjct: 224 TQDEVTTALGKLTRYIAELVATKRLSPKD----DLLGSLITDTD---------LTDEELT 270 Query: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350 L AG ETT+ L G L+++PE L Sbjct: 271 NIALILLVAGHETTANMLGLGTFALLQHPEQIANLDS----------------------- 307 Query: 351 DAVVHEIQRFITLVPSNLP-HEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKF 409 V E+ R++++V P A D G +I KG V L +V D + F +P+ Sbjct: 308 PDAVEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDIL 367 Query: 410 KPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDP-KD 468 + + + F G C G+ LAR+E+ + + F L P ++ Sbjct: 368 QLDRVD--------ARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEE 419 Query: 469 IDLSPIHIGFGC--IPPRY 485 I L +G +P + Sbjct: 420 IKLREKSAAYGVWALPVAW 438 >4TRI-A nrPDB Length = 407 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 83/431 (19%), Positives = 148/431 (34%), Gaps = 71/431 (16%) Query: 66 PVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDI 125 PVF G + Y+AV +A + FS G + I ++ P Sbjct: 35 PVFRDRNG---LAAATTYQAVLDA-ERNPELFSSTGGIRPDQPGMPYMIDMDD-PQHLLR 89 Query: 126 RRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRK---TQGQPFDPTFLIGCAPCNVIAD 182 R+ L N G ++ ++ L + L +G+ + P VI D Sbjct: 90 RK-----LVNAGFTRKRVMDKVDSIGR-LCDTLIDAVCERGECDFVRDIAAPLPMAVIGD 143 Query: 183 ILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEV 242 +L + +L L S H + +K++ A Sbjct: 144 MLG----------------VLPTERDMLLKWSDDLVCGLSS--HVDEAAIQKLMDTFAAY 185 Query: 243 KEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTE 302 E+ + + + + TD L + + +R+ + D I + G E Sbjct: 186 TEFTKDVITKRRA--------EPTDDLFSVLVNSEVEGQRM-SDDEIVFETLLILIGGDE 236 Query: 303 TTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFIT 362 TT TL G L+++ + + L ++D + + E+ R+ + Sbjct: 237 TTRHTLSGGTEQLLRHRDQWDALVADVD------------------LLPGAIEEMLRWTS 278 Query: 363 LVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFK 422 V N+ T DT+F G + G ++ +S +D F DP+ F+ + N + Sbjct: 279 PVK-NMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVA-- 335 Query: 423 YSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIP 482 F G C G LAR+EL L+ +L+ L D + L P + G P Sbjct: 336 -------FGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDAPVPLRPANFVSG--P 386 Query: 483 PRYKLCVIPRS 493 + P + Sbjct: 387 ESMPVVFTPSA 397 >5LIE-A nrPDB Length = 414 Score = 184 bits (468), Expect = 5e-47, Method: Composition-based stats. Identities = 73/371 (19%), Positives = 117/371 (31%), Gaps = 61/371 (16%) Query: 111 DRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFD-PT 169 + + + P IRR + L + E ++R A LL+ + G PFD Sbjct: 92 GQVLNMMDDPRHTRIRRLVSSGLT--PRMIRRVEDDLRRRARGLLDGVE--PGAPFDFVV 147 Query: 170 FLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLP 229 + P +I IL F + F+ +T Sbjct: 148 EIAAELPMQMIC-ILLGVPETDRHWLFEAVEPGFDFRGSRRAT----------------- 189 Query: 230 GSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSA--ERLYTMD 287 V + + Y E + + D +L + + Sbjct: 190 MPRLNVEDAGSRLYTYALELIAGKRA--------EPADDMLSVVANATIDDPDAPALSDA 241 Query: 288 GITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEM 347 + + LF AG ETT ++ GLL L + P+ + L + + Sbjct: 242 ELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFE----------------- 284 Query: 348 PYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE 407 + + EI R+ + PS A+R G I G VV S D F + Sbjct: 285 -LLPTAIEEIVRWTSPSPSK-RRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRAD 342 Query: 408 KFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK 467 +F N + F G C G LAR+EL +L +L F +V+P Sbjct: 343 EFDITRKPNPH---------LGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVVEPA 393 Query: 468 DIDLSPIHIGF 478 + S H G Sbjct: 394 EWTRSNRHTGI 404 >4WPZ-A nrPDB Length = 397 Score = 184 bits (466), Expect = 9e-47, Method: Composition-based stats. Identities = 81/422 (19%), Positives = 137/422 (32%), Gaps = 80/422 (18%) Query: 79 VMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRD--------RGIIFNNGPTWKDIRRFSL 130 ++ + V++ L+D FS + A A + ++ + P +R+ Sbjct: 41 MVTKHADVRKVLVD--SRFSSKVMATAAAAMSETETGKLMNESLVGMDAPEHTRLRKLVT 98 Query: 131 TTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGC-APCNVIADILFRKHF 189 + + RI LL+ L +P D P VI ++L Sbjct: 99 KAFTARRV--ETLRPRITELVGQLLDELETLP-RPVDLVKNFSVPLPVRVICELLGVPAG 155 Query: 190 DYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSER 249 D + F+ + L W Q+ + Y E Sbjct: 156 DQDT---------FHAWSNALLGDWQQVVEK---------------EAATVSLVNYFGEL 191 Query: 250 VKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLR 309 + + N DL L+ + T I + AG ETT+ + Sbjct: 192 IAVKRE----NPADDLISELIAI-----SDGDSTLTEREIIALSIGILSAGHETTANQIS 242 Query: 310 YGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSN-- 367 L+ L+ PE +KL + + + V E+ RF+ L + Sbjct: 243 MFLVTLLHNPEELDKLRDNREAI------------------PKAVDELLRFVPLTTTGGI 284 Query: 368 LPHEATRDTIF-RGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY 426 +P T + G ++P G VV+P + + D + F D E+ N + Sbjct: 285 IPRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLNVTRENNPH-------- 336 Query: 427 FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK-DIDLSPIHI--GFGCIPP 483 F G C G LAR+EL L AIL L P+ ++ L I G +P Sbjct: 337 -LAFGAGIHHCLGAQLARIELQEALGAILDRMPQVRLAVPESELRLKSASIIRGLESLPI 395 Query: 484 RY 485 + Sbjct: 396 TW 397 >3A50-A nrPDB Length = 411 Score = 181 bits (459), Expect = 6e-46, Method: Composition-based stats. Identities = 82/452 (18%), Positives = 144/452 (31%), Gaps = 78/452 (17%) Query: 51 KNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLD--YKDEFSGRG------D 102 +N ++ L PV L + + ++ Y V+EA +D ++ R D Sbjct: 20 QNPHPAYAALRAE-DPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHRLPEDQRAD 78 Query: 103 LPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQ 162 +PA +I + P +R+ + M + E RI A LL L T Sbjct: 79 MPATPTPM---MILMDPPDHTRLRKLVGRSFTVRRMNE--LEPRITEIADGLLAGL-PTD 132 Query: 163 GQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFP 222 G P VI ++L D +D + W + + Sbjct: 133 GPVDLMREYAFQIPVQVICELLGLPAEDRDD-----------------FSAWSSVLVDDS 175 Query: 223 SFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAER 282 + ++ Y+S+ ++ D D LL + Sbjct: 176 PADDK--------NAAMGKLHGYLSDLLERKRTEPD--------DALLSSLLAVSDMDGD 219 Query: 283 LYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIK 342 + + + L AG ETT + G+L L+ +P+ + L E+ Sbjct: 220 RLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPDQRKLLAED-------------- 265 Query: 343 DRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQE 402 + + V E RF + V D + G IP G +V+ L + D Sbjct: 266 ----PSLISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADW 321 Query: 403 FPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAIL-QHFNLK 461 P+P++ + F G C G LAR+E + + + L Sbjct: 322 MPEPDRLDITRDASGG---------VFFGHGIHFCLGAQLARLEGRVAIGRLFADRPELA 372 Query: 462 PLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS 493 V ++ + G R + + PRS Sbjct: 373 LAVGLDELVYRRSTLVRGL--SRMPVTMGPRS 402 >4Z5P-A nrPDB Length = 400 Score = 181 bits (459), Expect = 6e-46, Method: Composition-based stats. Identities = 71/366 (19%), Positives = 118/366 (32%), Gaps = 62/366 (16%) Query: 105 AFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQ 164 A R I+ + P +RR MG +S ++ LL+ + +T Sbjct: 77 TPLARRSDTILSLDPPEHTRLRRLLSKAFTARRMG--AMQSWLEELFAGLLDGVERTGHP 134 Query: 165 PFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSF 224 L VI +L + D + + ++ST Sbjct: 135 ADIVRDLAQPFTIAVICRLLGVPYEDRG--------RFQHWSEVIMSTTAY--------- 177 Query: 225 LHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLY 284 S + + A ++ Y+++ V + D LL + + +RL Sbjct: 178 ------SKEEAVSADASIRAYLADLVSARRAA--------PHDDLLGVLVSARDDDDRLT 223 Query: 285 TMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDR 344 + IT V L AG ET++ L + L+ + + L E Sbjct: 224 EDELITFGVT-LLVAGHETSAHQLGNMVYALLTHEDQLSLLRE----------------- 265 Query: 345 QEMPYMDAVVHEIQRFITLVP-SNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF 403 + + V E+ RF+ L A D G + G VV + D + F Sbjct: 266 -QPELLPRAVEELLRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAF 324 Query: 404 PDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL 463 DP++ N + F G C G LARMEL + + +L+ F L Sbjct: 325 DDPDRLDITREKNPH---------LAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRL 375 Query: 464 VDPKDI 469 P D Sbjct: 376 AVPADQ 381 >5IT1-A nrPDB Length = 399 Score = 180 bits (457), Expect = 9e-46, Method: Composition-based stats. Identities = 73/414 (17%), Positives = 129/414 (31%), Gaps = 70/414 (16%) Query: 80 MHGYKAVKEALLD----YKDEFSGRGDLPAFHAHRDRG-IIFNNGPTWKDIRRFSLTTLR 134 + GY+ V+ L D + RG +++ + P D R+ Sbjct: 48 VTGYEQVRAVLRDPSFSVGVPHALHTQDGVVTQKPGRGSLLWQDAPEHTDDRKLLAKEFT 107 Query: 135 NYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDE 194 M Q IQR L+A+ + +G P D +++ LF + E Sbjct: 108 VRRM--QALRPNIQRIVDEHLDAI-EARGGPVDLVKTFANPVPSMVISDLFGVPAERRAE 164 Query: 195 KFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHH 254 F E + + + + V+E Sbjct: 165 --------FQEIAEAMMRVDQDAAAT---------------EAAGMRLGGLLYQLVQERR 201 Query: 255 QSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLI 314 N DL L+ + + + L A +TT+ + G + Sbjct: 202 A----NPGDDLISALIT-----TEDPDGVIDDMFLMNAAGTLLIAAHDTTACMIGLGTAL 252 Query: 315 LMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATR 374 L+ P+ L ++ + V E+ R++T+ AT+ Sbjct: 253 LLDRPDQLALLQKD------------------PSLIGNAVEELLRYLTIGQFGAERVATQ 294 Query: 375 DTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGK 434 D G I KG VV L S +D DPE+F + F G Sbjct: 295 DGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDITRRPAPH---------LAFGFGA 345 Query: 435 RVCAGEGLARMELFLLLCAILQHFNLKPLVDP-KDIDLSPIHIGFGC--IPPRY 485 C G+ LAR+EL ++ + + F L P +++ + +G +P + Sbjct: 346 HQCIGQQLARIELQIVFGTLFRRFPTLRLAKPVEELRFRNDMVFYGVHELPVTW 399 >5NWS-A nrPDB Length = 435 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 79/438 (18%), Positives = 137/438 (31%), Gaps = 82/438 (18%) Query: 50 LKNIPKSFTRLAQRFGPVFTLY-VGSQRMVVMHGYKAVKEAL-----LDYKDEFSGRGDL 103 L + + RL +R GPV V + + Y V+ L ++ G G Sbjct: 33 LADPFTGYGRLRER-GPVVRGRFVDGTPVWFVTRYDDVRAVLRDPRFVNTPSPVPGEGGA 91 Query: 104 PAFHAHRD-------------RGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQRE 150 D I+ ++ P +RR + G I+R Sbjct: 92 DPREGMMDLLNVPEPLRVYLLGSILDSDPPDHPRLRRLVTRAFAARRI--LGLRPGIERI 149 Query: 151 AHFLLEAL--RKTQGQPFDPTFLIGC-APCNVIADILFRKHFDYNDEKFLRLMYLFNENF 207 A LL L R+ + D VI +++ D + Sbjct: 150 ADRLLAELPRREEEDGTVDLLEHFAYPLSITVICELVGIPATDLERWR--------EWGG 201 Query: 208 HLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTD 267 L+S +L ++FP + +Y +++ + LTD Sbjct: 202 DLVSMRPERLRHSFPVMI------------------DYCHRLIEQRRAA--------LTD 235 Query: 268 CLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHE 327 LL E+ + + + + L AG ET++ + G L+ +P L + Sbjct: 236 DLLSELIRAQDDDGGRLSDIETVTMILTLVLAGHETSAHLIGNGTAALLTHPGQWALLRK 295 Query: 328 EIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGT 387 + + VHE+ R+ V AT D G + +G Sbjct: 296 D------------------PALLPRAVHELMRWCGSVHVARLRYATEDLELAGTPVARGD 337 Query: 388 VVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMEL 447 V L S +D + + DP++ ++ F G C G LAR E Sbjct: 338 AVQLVLVSANFDPRHYSDPDRLDITRHQE-----GQAENHVGFGHGIHYCLGATLARQEG 392 Query: 448 FLLLCAILQHFNLKPLVD 465 + L +L+ + L D Sbjct: 393 EVALARLLETYPDLALAD 410 >5XW2-A nrPDB Length = 419 Score = 178 bits (451), Expect = 6e-45, Method: Composition-based stats. Identities = 82/411 (19%), Positives = 134/411 (32%), Gaps = 58/411 (14%) Query: 80 MHGYKAVKEALLDYKDEFSGRGDLPAFHA---HRDRGIIFNNGPTWKDIRRFSLTTLRNY 136 ++GY E L D S L A + ++ + P +++R+ Sbjct: 57 VYGYAEAIEVLGDPGTFSSHMSRLLPMGADEAFTEGDLLQTDPPDHRELRKLVSHAFTPK 116 Query: 137 GMGKQGNESRIQREAHFLLEALRKTQGQPFDP-TFLIGCAPCNVIADILFRKHFDYNDEK 195 + + E RI LL+A+ FD T L P V+A++L D Sbjct: 117 VVAE--LEPRITALTQELLDAVADRD--TFDLMTALAYPLPVTVVAELLSIPSADR---- 168 Query: 196 FLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQ 255 +LF + + + P ++ + + E ++EH Sbjct: 169 -----HLFEGWMTEIVHSLGDVS------MEDAPEDQERIFEAGMAPMRKMLEYLREHAA 217 Query: 256 SLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLIL 315 DL L+ E R T + I L AG TT+ + +L L Sbjct: 218 ECRRRPRGDLMGKLI-----EAEVDGRRLTDNHIVNFAKMLLIAGYLTTTMLIGNTVLCL 272 Query: 316 MKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRD 375 YPE ++ DR +P + + E RF++ V + TRD Sbjct: 273 DSYPEQAARVRA---------------DRSLIPGL---LEESMRFLSPV-AATYRATTRD 313 Query: 376 TIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKR 435 G + +V+ + D ++F +PE F N + F G Sbjct: 314 VEVAGQRLSADQMVMVWFGAANRDARQFAEPELFDMTRGPNPH---------LGFGRGIH 364 Query: 436 VCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSP--IHIGFGCIPPR 484 C G LARME + L +L F + P G +P R Sbjct: 365 FCLGGPLARMEGRVALDHLLDRFPELYTDPERPPTFMPGFDTTGVSSLPLR 415 >3SN5-A nrPDB Length = 491 Score = 177 bits (450), Expect = 6e-45, Method: Composition-based stats. Identities = 90/495 (18%), Positives = 167/495 (33%), Gaps = 54/495 (10%) Query: 22 MWRQVHSSWNL---PPGPFPL-PIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRM 77 M ++ S PP L P +G Q N + ++ G VFT + + + Sbjct: 1 MAKKTSSRRRQTGEPPLENGLIPYLGCALQFGA-NPLEFLRANQRKHGHVFTCKLMGKYV 59 Query: 78 VVMHGYKAVKEALLD-YKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNY 136 + + + L ++ + A R I +G T ++I + TL+ + Sbjct: 60 HFITNPLSYHKVLCHGKYFDWKKFHFALSAKAFGHRSIDPMDGNTTENINDTFIKTLQGH 119 Query: 137 GMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKF 196 + ++E L++ P + +R F+ + Sbjct: 120 ALNSL---------TESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAG---Y 167 Query: 197 LRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLP----GSHRKVIKNVAEVKEYVSERVKE 252 L + L +NF F P G + + +E ++E ++ Sbjct: 168 LTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLR- 226 Query: 253 HHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGL 312 H +L L + S + T + +A T + L Sbjct: 227 HENLQKRESISELIS--LRMFLNDTLST---FDDLEKAKTHLVVLWASQANTIPATFWSL 281 Query: 313 LILMKYPEIEEKLHEEIDRVI----------GPSRIPAIKDRQEMPYMDAVVHEIQRFIT 362 +++ PE + EE+ R + G + + ++P +D+++ E R + Sbjct: 282 FQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSS 341 Query: 363 LVPSNLPHEATRDTIF----RGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNEN 418 S A D Y I K ++ + D + +PDP FK + +L+EN Sbjct: 342 A--SLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDEN 399 Query: 419 GK---------FKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLV-DPKD 468 GK K Y+ PF +G +C G A E+ L +L +F L+ + K Sbjct: 400 GKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKC 459 Query: 469 IDLSPIHIGFGCIPP 483 L G G +PP Sbjct: 460 PPLDQSRAGLGILPP 474 >5XNT-A nrPDB Length = 411 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 77/387 (19%), Positives = 118/387 (30%), Gaps = 70/387 (18%) Query: 83 YKAVKEALLDYKDEFSGRGDLPAFHAHRDR--------GIIFNNGPTWKDIRRFSLTTLR 134 Y+ VK L DYK S R I + P + R Sbjct: 49 YEDVKRVLSDYKHFSSVRKRTTISVGTDSEEGSVPDKIKITEADPPEHRKRRSLLAAAFT 108 Query: 135 NYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPT-FLIGCAPCNVIADILFRKHFDYND 193 + Q E RIQ A L+E + + D L P V++D++ D Sbjct: 109 PRSL--QNWEPRIQEIADELIEEMDEE--TEIDIVQSLASPLPIIVMSDLMGVPSKD--- 161 Query: 194 EKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIK-NVAEVKEYVSERVKE 252 LL W+ + F F ++ + E +Y+ V + Sbjct: 162 --------------RLLFKKWVDIL--FLPFDKEKQEEVNELKQVAAKEYYQYLYPIVVQ 205 Query: 253 HHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGL 312 N D+ LL ++T D + T + AG ETTS L Sbjct: 206 KR----LNPADDIISDLLKA-----EVDGEMFTDDEVVRTTMLILGAGVETTSHLLANSF 256 Query: 313 LILM-KYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHE 371 L+ E+ ++LHE + + V E+ R+ L Sbjct: 257 YSLLYDDKEVYQELHE------------------NLDLVPQAVEEMLRYR-FNLIKLDRT 297 Query: 372 ATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFS 431 D G + +G VV + + D + F D N+ F Sbjct: 298 VKEDNDLLGVELKEGENVVVWMSAANLDEEMFEDAFTLNIHRPNNK--------KHLTFG 349 Query: 432 TGKRVCAGEGLARMELFLLLCAILQHF 458 G C G LAR+E + L L+ F Sbjct: 350 NGPHFCLGAPLARLEAKIALTTFLKKF 376 >2WIO-A nrPDB Length = 431 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 79/425 (18%), Positives = 138/425 (32%), Gaps = 64/425 (15%) Query: 49 ELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHA 108 + + + ++ PV+ G + + + V+ L D S + + Sbjct: 46 DETALLDWLGTMREK-QPVWQDRYG---VWHVFRHADVQTVLRDTATFSSDPTRVIEGAS 101 Query: 109 HRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDP 168 I + P + +R+ + + E RI+ LL G+ FD Sbjct: 102 PTPGMIHEIDPPEHRALRKVVSSAFTPRTISD--LEPRIRDVTRSLLAD----AGESFDL 155 Query: 169 TFLI-GCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHY 227 ++ P ++A + L L + +E F S + + + P Sbjct: 156 VDVLAFPLPVTIVA-------------ELLGLPPMDHEQFGDWSGALVDIQMDDP----T 198 Query: 228 LPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMD 287 P ++ + + Y+ R E D D L+ + + R + Sbjct: 199 DPALAERIADVLNPLTAYLKARCAERRA--------DPGDDLISRLVLAEVDG-RALDDE 249 Query: 288 GITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEM 347 L AG TT+ L + L ++P + E+ P RIP Sbjct: 250 EAANFSTALLLAGHITTTVLLGNIVRTLDEHPAHWDAAAED------PGRIP-------- 295 Query: 348 PYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE 407 A+V E+ R+ P + T+ T G IP +V + S D+ DP+ Sbjct: 296 ----AIVEEVLRYRPPFPQ-MQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPD 350 Query: 408 KFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK 467 +F P F G C G LAR+E + L I+ F + VD Sbjct: 351 RFDPSRK-------SGGAAQLSFGHGVHFCLGAPLARLENRVALEEIIARFG-RLTVDRD 402 Query: 468 DIDLS 472 D L Sbjct: 403 DERLR 407 >6FSH-A nrPDB Length = 398 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 69/397 (17%), Positives = 122/397 (30%), Gaps = 77/397 (19%) Query: 82 GYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFN----------NGPTWKDIRRFSLT 131 G+ V++ L D++ FS R +GI + P +R Sbjct: 47 GHAVVRQVLGDHQQ-FSTRRRWDPRDEIGGKGIFRPRELVGNLMDYDPPEHTRLRHLLTP 105 Query: 132 TLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLI-GCAPCNVIADILFRKHFD 190 M + RI+ L+A+ + G P D L P V+ +++ D Sbjct: 106 GFTQRRM--RRLAPRIEEIVTDRLDAM-EQAGPPADLIELFADEVPGAVLCELIGVPRDD 162 Query: 191 YNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERV 250 + F L L S ++ + Y+ + Sbjct: 163 -------------RDMFMKLCHGHLDASL-----------SQKRRAALGDKFSRYLLAMI 198 Query: 251 KEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRY 310 +D D + + E T + + L AG + S + Sbjct: 199 ARER--------KDPGDGFIGSIVAEHGDT---ITDEELRGVCVQLMLAGDDNVSGMIGL 247 Query: 311 GLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPH 370 G+L L+++PE L + D V E+ R++T+ + P Sbjct: 248 GVLALLRHPEQIAALRGDDQS------------------ADRAVDELIRYLTVPYAPTPR 289 Query: 371 EATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPF 430 A D + +I +G V+ +L D PD ++ + F Sbjct: 290 TAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTRTPVPHVA---------F 340 Query: 431 STGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK 467 G C G L R++L + A+ + F L DP Sbjct: 341 GHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPA 377 >6GMF-A nrPDB Length = 397 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 82/411 (19%), Positives = 138/411 (33%), Gaps = 69/411 (16%) Query: 71 YVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPA------FHAHRDRGIIFNNGPTWKD 124 + Q + + Y+ V L D FS RG + + I+ + P Sbjct: 31 RLQPQGFMAVGRYQDVARVLHD-AKGFSNRGWAASLPRGVKWDTSMPPSIVQVDPPRHGK 89 Query: 125 IRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADIL 184 +R + + E RI+ AH L++ LR + P VIA++L Sbjct: 90 LRTLVTKAFTPRTVAQ--LEPRIRDIAHELVDGLRGKSTFEATVEVTV-PMPMIVIAEML 146 Query: 185 FRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKE 244 D F R + L+ G+ ++ ++ E Sbjct: 147 GVAPERRAD--FKRWSDDMVGSLALVRV-----------------GNAAQLERSTQEFYA 187 Query: 245 YVSERVKEHHQSLDPNCPRDLTDCLLV-EMEKEKHSAERLYTMDGITVTVADLFFAGTET 303 Y SE + + DL LL E++ EK +A + + L AG ET Sbjct: 188 YFSEVL----EERRREPREDLISQLLAAEVDGEKLTAGEVLSFAN------TLLIAGNET 237 Query: 304 TSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITL 363 T++ + L+ L +PE + + + AVV E+ R+ + Sbjct: 238 TTSLIGNALVALTDHPEQLAAAQAD------------------LSLVPAVVEEVLRYESP 279 Query: 364 VPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKY 423 + + D IP +VV+P L S D FPDP++F + Sbjct: 280 AQC-IFRQTMTDVEIGDERIPARSVVLPLLASANRDESRFPDPDRFDIHRDTKGH----- 333 Query: 424 SDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPI 474 F C G LAR+E ++L +L +++ SP Sbjct: 334 ----LAFGLDIHFCIGAPLARLEAKVMLEVLLARLG-DIQRVSQEVSWSPS 379 >1Z8P-A nrPDB Length = 404 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 75/437 (17%), Positives = 136/437 (31%), Gaps = 81/437 (18%) Query: 66 PVFTLYVGSQRMVVMHGYKAVKEALLD-------------YKDEFSGRGDLPA-FHAHRD 111 PV + Q ++ GY K AL D + EF P + Sbjct: 28 PVTPVRFLGQDAWLVTGYDEAKAALSDLRLSSDPKKKYPGVEVEFPAYLGFPEDVRNYFA 87 Query: 112 RGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFL 171 + ++ PT +R+ + + R+++ LL+ + D Sbjct: 88 TNMGTSDPPTHTRLRKLVSQEFTVRRV--EAMRPRVEQITAELLDEV--GDSGVVDIVDR 143 Query: 172 IGC-APCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPG 230 P VI + L + + F S+ L P Sbjct: 144 FAHPLPIKVIC-------------ELLGVDEKYRGEFGRWSS----------EILVMDPE 180 Query: 231 SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGIT 290 + + EV ++ + V+ + D LL + + + + + D +T Sbjct: 181 RAEQRGQAAREVVNFILDLVERRRT--------EPGDDLLSALIRVQDDDDGRLSADELT 232 Query: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350 L AG E++ + + G +L+ +P+ + + + Sbjct: 233 SIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVRRDPSA------------------L 274 Query: 351 DAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410 V EI R+I P A + G IP+ + V+ + D ++FPDP +F Sbjct: 275 PNAVEEILRYIAP-PETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRFD 333 Query: 411 PEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL---VDPK 467 + F G C G LA++E + L A+ F L D Sbjct: 334 VTRDTRGHLS---------FGQGIHFCMGRPLAKLEGEVALRALFGRFPALSLGIDADDV 384 Query: 468 DIDLSPIHIGFGCIPPR 484 S + G +P R Sbjct: 385 VWRRSLLLRGIDHLPVR 401 >6A7J-A nrPDB Length = 411 Score = 176 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 90/423 (21%), Positives = 153/423 (36%), Gaps = 86/423 (20%) Query: 65 GPVFTLYV-GSQRMVVMHGYKAVKEALLDYKDEFSG--------RGDLPAF-----HAHR 110 GP+ + + G + + +K + ALL RG++PA + Sbjct: 26 GPLAEVELPGGVHVYAVTHHKEAR-ALLTDSRVVKDINVWNAWQRGEIPADWPLIGLVNP 84 Query: 111 DRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESR---IQREAHFLLEALRKTQ-GQPF 166 R ++ +GP + +R TL + + E I+ + LE L G+P Sbjct: 85 GRSMLTVDGPDHRRLR-----TLVAQALTVKRVEKLRAGIEALTNASLERLAALPAGEPV 139 Query: 167 DPTFLIGC-APCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFL 225 D P NVI++++ D+ RL LF + F + P Sbjct: 140 DLKAEFAYPLPMNVISELMGVDAADHP-----RLKELFEKFFSTQTPPE----------- 183 Query: 226 HYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYT 285 +V + +A++ ++ V+E N DLT L+ E H T Sbjct: 184 --------EVPQMMADLGTLFTKIVEEKKA----NPGDDLTSALIAASEDGDH-----LT 226 Query: 286 MDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQ 345 + I T+ + AG ETT + + + L +PE +K+ IP Sbjct: 227 DEEILNTLQLIIAAGHETTISLIVNVVEALAIHPEQRKKV--------LSGEIP------ 272 Query: 346 EMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF-P 404 + V+ E R+ T L AT D ++PKG +V + ++ D +++ P Sbjct: 273 ----WEGVIEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGP 328 Query: 405 DPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLV 464 F N + F G VC G L+R+E + L A+ + F L Sbjct: 329 TAGDFDATRTPNRHIA---------FGHGPHVCPGAALSRLEAGIALPALYERFPELDLA 379 Query: 465 DPK 467 P Sbjct: 380 VPA 382 >3ABB-A nrPDB Length = 408 Score = 176 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 79/419 (18%), Positives = 136/419 (32%), Gaps = 77/419 (18%) Query: 74 SQRMVVMHGYKAVKEALLD-YKDEFSGRGDLPAF--HAHRDRGIIF----NNGPTWKDIR 126 + ++ G+ + L+D G D P G+ F + P R Sbjct: 47 GRPAWLITGHAEGRALLVDPRLSSDWGHPDFPVVVRRTEDRGGLAFPLIGVDDPVHARQR 106 Query: 127 RFSLTTLRNYGMGKQ-GNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNV-IADIL 184 R + + +G+ + R+Q LL+ + +G D +V I ++L Sbjct: 107 RMLIPS---FGVKRMNAIRPRLQSLVDRLLDDML-AKGPGADLVSAFALPVPSVAICELL 162 Query: 185 FRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKE 244 + D++ + + NF + E+ Sbjct: 163 GVPYGDHD--------------------FFEECSRNFVGAAT-----SAEADAAFGELYT 197 Query: 245 YVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETT 304 Y+ V + D LL E+ + L D + + L AG ETT Sbjct: 198 YLHGLVGRKQA--------EPEDGLLDELIARQLEEGDL-DHDEVVMIALVLLVAGHETT 248 Query: 305 STTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLV 364 + G L L+++PE + L + V G VV E+ RF + V Sbjct: 249 VNAIALGALTLIQHPEQIDVLLRDPGAVSG------------------VVEELLRFTS-V 289 Query: 365 PSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYS 424 ++ A D G I G V+ ++ + D + + +P+ F + Sbjct: 290 SDHIVRMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFDARRN---------A 340 Query: 425 DYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPP 483 + F G C G+ LAR EL + L + L P +D PI G P Sbjct: 341 RHHVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLAVP--LDEVPIKAGHDAQGP 397 >2XKR-A nrPDB Length = 398 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 89/431 (20%), Positives = 145/431 (33%), Gaps = 74/431 (17%) Query: 66 PVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSG----RGDLPAFHAHRDRGIIFNNGPT 121 PVF G Y+AV +A + FS R D PA D + P Sbjct: 32 PVFRDRNGLA---AASTYQAVIDA-ERQPELFSNAGGIRPDQPALPMMIDM-----DDPA 82 Query: 122 WKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIA 181 R+ + + E+ I L++A+ + +G+ L P VI Sbjct: 83 HLLRRKLVNAGFTRKRVKDK--EASIAALCDTLIDAVCE-RGECDFVRDLAAPLPMAVIG 139 Query: 182 DILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAE 241 D+L + D FLR W F S H + + A Sbjct: 140 DML-GVRPEQRD-MFLR---------------WSDDLVTFLS-SHVSQEDFQITMDAFAA 181 Query: 242 VKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGT 301 ++ + D TD L+ + + ERL + D + + + G Sbjct: 182 YNDFTRATIAARRA--------DPTDDLVSVLVSSEVDGERL-SDDELVMETLLILIGGD 232 Query: 302 ETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFI 361 ETT TL G L++ + + L + + + E+ R+ Sbjct: 233 ETTRHTLSGGTEQLLRNRDQWDLLQRD------------------PSLLPGAIEEMLRWT 274 Query: 362 TLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKF 421 V N+ T DT F G + G ++ +S +D F +PEKF + N + Sbjct: 275 APVK-NMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQRNPNSH--- 330 Query: 422 KYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF-NLKPLVDPKDIDLSPIHIGFGC 480 F G C G LAR+EL L+ +L+ +L+ + D + L P + G Sbjct: 331 ------LAFGFGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGL 384 Query: 481 IPPRYKLCVIP 491 + P Sbjct: 385 ESMP--VVFTP 393 >5YSW-A nrPDB Length = 441 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 79/452 (17%), Positives = 154/452 (34%), Gaps = 83/452 (18%) Query: 52 NIPKSFTRLAQRFGPVFTLYVG-SQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAH- 109 ++P + +++R GPV + ++ GY+ + L D S R + Sbjct: 52 HVPPALVAVSER-GPVARATLAAGDPFWLVSGYEEARAVLSD-PRFSSDRFQYHPWFKEL 109 Query: 110 -------------RDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLE 156 R I + P R+ + + G +RI ++ Sbjct: 110 SPEFRERLRDDKARAGSFINMDPPEHTRYRKLLTGQFTVRRIRELG--ARIDEIVAGRVD 167 Query: 157 ALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQ 216 A+ T AP +I ++L ++ D Sbjct: 168 AMLAGGTTADLMTEFAFPAPSLMICELLGVRYEDR------------------------A 203 Query: 217 LYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKE 276 + S L + + +KN ++ ++ V + N D+ L+ Sbjct: 204 EFQQRASALLQMNAPVAEAVKNADALRAFMQALVTDKRA----NPAGDIISGLIHHA--- 256 Query: 277 KHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPS 336 A+ T D + L AG +TT++ L G+ +L++ P L ++ R+ Sbjct: 257 --GADPALTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDDPSRIAD-- 312 Query: 337 RIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSV 396 V E+ R++++V + A D F G IP G+ VV ++ + Sbjct: 313 ----------------AVEELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVAT 356 Query: 397 LYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQ 456 D + +PDP+ + F G C G+ LARME+ +L+ Sbjct: 357 NRDARHWPDPD-LDLTRPRGPH---------LAFGHGVHQCLGQQLARMEMQAGYAELLR 406 Query: 457 HFN-LKPLVDPKDIDLSPIHIGFGC--IPPRY 485 ++ V P+++ L + +G +P + Sbjct: 407 RLPNVRLAVPPEEVPLRNDMLTYGVHSLPIAW 438 >1UED-A nrPDB Length = 406 Score = 174 bits (442), Expect = 5e-44, Method: Composition-based stats. Identities = 73/417 (17%), Positives = 133/417 (31%), Gaps = 79/417 (18%) Query: 65 GPVFTL------YVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRD------R 112 GP+ + +G + HGY+ V+ L D+ + F+ R + Sbjct: 37 GPLVRIVGESSTQLGRDFVWQAHGYEVVRRILGDH-EHFTTRPQFTQSKSGAHVEAQFVG 95 Query: 113 GIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLI 172 I + P +R+ + + E IQ L+ L + +G D L Sbjct: 96 QISTYDPPEHTRLRKMLTPEFTVRRI--RRMEPAIQSLIDDRLDLL-EAEGPSADLQGLF 152 Query: 173 GCAP-CNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGS 231 + + ++L D +F+R + + L Sbjct: 153 ADPVGAHALCELLGIPRDD--QREFVRRIRRNADLSRGL--------------------- 189 Query: 232 HRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITV 291 + + A Y+ + D D LL + ++ T + + Sbjct: 190 -KARAADSAAFNRYLDNLLARQRA--------DPDDGLLGMIVRDHGDN---VTDEELKG 237 Query: 292 TVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMD 351 L G ET + + +G+L L+ P E L E ++ + Sbjct: 238 LCTALILGGVETVAGMIGFGVLALLDNPGQIELLFESPEK------------------AE 279 Query: 352 AVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKP 411 VV+E+ R+++ V + P A +D + G LI G V+ ++ D PDP+ Sbjct: 280 RVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPDVLDA 339 Query: 412 EHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKD 468 + F G C G LAR L + + + F L P + Sbjct: 340 NR---------AAVSDVGFGHGIHYCVGAALARSMLRMAYQTLWRRFPGLRLAVPIE 387 >6B11-A nrPDB Length = 440 Score = 174 bits (442), Expect = 6e-44, Method: Composition-based stats. Identities = 73/420 (17%), Positives = 136/420 (32%), Gaps = 73/420 (17%) Query: 74 SQRMVVMHGYKAVKEALLD-YKDEFSG---RGDLPAFHAHRDRGIIFNNGPTWKDIRRFS 129 + ++ V+ L D R A R ++ + P +R Sbjct: 86 GAPVWLISRQDHVRALLADPRVSIHPAKLPRLSPSDGEAEASRSLLTLDPPDHGALRGHF 145 Query: 130 LTTLRNYGMGK-QGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKH 188 + +G+ + + +++ LL+ L + VI +L Sbjct: 146 ---IPEFGLRRVRELRPSVEQIVTGLLDDLTARGDEADLLADFALPMATQVICRLL---D 199 Query: 189 FDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSE 248 Y D + F E P + + ++ + E+++Y+ Sbjct: 200 IPYEDRDY------FQERTEQA----------------TRPAAGEEALEALLELRDYLDR 237 Query: 249 RVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTL 308 + R+ D +L M + + + L AG ETT++ + Sbjct: 238 LI-------SGKTGRESGDGMLGSMVAQARGGG--LSHADVLDNAVLLLAAGHETTASMV 288 Query: 309 RYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNL 368 +L+L+++P +L + V E+ R++++ L Sbjct: 289 TMSVLVLLQHPTAWREL------------------TVNPGLLPGAVDELLRYLSIA-DGL 329 Query: 369 PHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFK 428 AT D G+ I G +V L + D F +PE F + Sbjct: 330 RRSATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHRSARRHVA-------- 381 Query: 429 PFSTGKRVCAGEGLARMELFLLLCAILQHFN-LKPLVDPKDIDLSPIHIGFGC--IPPRY 485 F G C G+ LARMEL + L A+L+ L+P D + L FG +P + Sbjct: 382 -FGYGPHQCLGQNLARMELEVALGAVLERLPALRPTTDVAGLRLKSDSAVFGVYELPVAW 440 >1CPT-A nrPDB Length = 428 Score = 174 bits (441), Expect = 7e-44, Method: Composition-based stats. Identities = 76/399 (19%), Positives = 134/399 (33%), Gaps = 49/399 (12%) Query: 88 EALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRI 147 E L D +E R + H + + PT R +L + + + E I Sbjct: 77 EILYDQNNEAFMR-SISGGCPHVIDSLTSMDPPTHTAYRGLTLNWFQPASI--RKLEENI 133 Query: 148 QREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENF 207 +R A ++ L G+ T P +V+ L D L+L F Sbjct: 134 RRIAQASVQRLLDFDGECDFMTDCALYYPLHVVMTALGVPEDDE--PLMLKLTQDFFGVH 191 Query: 208 HLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTD 267 + + R+ + +A +Y + + +CP+D Sbjct: 192 EPDEQAVAAPRQSADE-------AARRFHETIATFYDYFNGFTVDRR-----SCPKDDVM 239 Query: 268 CLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHE 327 LL + + I + AG +TTS++ ++ L + PE Sbjct: 240 SLLANSKLD----GNYIDDKYINAYYVAIATAGHDTTSSSSGGAIIGLSRNPEQLALAKS 295 Query: 328 EIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGT 387 + P+ IP + V E R+ V S A DT RG I +G Sbjct: 296 D------PALIPRL------------VDEAVRWTAPVKS-FMRTALADTEVRGQNIKRGD 336 Query: 388 VVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMEL 447 ++ + S D + F +P++F F N + F G +C G+ LA++E+ Sbjct: 337 RIMLSYPSANRDEEVFSNPDEFDITRFPNRH---------LGFGWGAHMCLGQHLAKLEM 387 Query: 448 FLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYK 486 + +L L P + + G +P R+ Sbjct: 388 KIFFEELLPKLKSVELSGPPRLVATNFVGGPKNVPIRFT 426 >3WVS-A nrPDB Length = 401 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 70/417 (16%), Positives = 122/417 (29%), Gaps = 66/417 (15%) Query: 74 SQRMVVMHGYKAVKEALLDY--KDEFSGRGDLPAFHAHRDRGIIFNN--GPTWKDIRRFS 129 + + Y+ + L D S D P + N P +RR Sbjct: 46 GEPAWLATRYEDARLVLGDARFSRALSEEHDPPRARKFNAQAKSMFNMDAPDHTRLRRLI 105 Query: 130 LTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHF 189 + + ++ AH L++ + P VI Sbjct: 106 SKAFTIRRVEELR--PKVHDLAHRLIDDMLAKGEPADLVADYALPIPTTVIC-------- 155 Query: 190 DYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSER 249 + L + + E F + L P E+ Y+ Sbjct: 156 -----ELLGVPFEDREKFGRWTDAILSTSTLNPEEGRVKR----------MELVGYIGGI 200 Query: 250 VKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLR 309 + DL ++ + + T + L AG ETT++ + Sbjct: 201 IAARRA----QPADDLISGMIEARDVQDK-----LTEQELLDHCIGLLIAGHETTASQIP 251 Query: 310 YGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVP-SNL 368 + L+ P+ ++L + + + V E+ RF+ L S Sbjct: 252 SFVYALLDQPQHWKRL------------------LDDPELIPSAVEELFRFVPLGSGSAA 293 Query: 369 PHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFK 428 P A D G L+ G V+ L + D F DPE+ K + S++ Sbjct: 294 PRYAREDIEVGGTLVRAGEPVLVALGAANRDGLRFEDPEEIKLDR---------PSNHHI 344 Query: 429 PFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRY 485 F G C G LAR+EL L A+L+ + + G +P + Sbjct: 345 GFGHGIHHCLGAPLARLELQEALRALLERLPTLKVAGDIAWKSEMMVRGPRSMPVGW 401 >4TX3-A nrPDB Length = 404 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 72/396 (18%), Positives = 125/396 (31%), Gaps = 75/396 (18%) Query: 82 GYKAVKEALLDYKDE-----FSGRGDLPAFHAHRDRGIIFN----NGPTWKDIRRFSLTT 132 G+ V++ L D+K F R ++ R R ++ N + P +R Sbjct: 53 GHAVVRQVLGDHKRFSTRRRFDRRDEIGGTGVFRPRELVGNLMDYDPPEHTRLRHLLTPG 112 Query: 133 LRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLI-GCAPCNVIADILFRKHFDY 191 M + RI+ L+A+ + G P D L P V+ +++ D Sbjct: 113 FTQRRM--RRLAPRIEEIVTDRLDAM-EQAGPPADLIELFADEVPGAVLCELIGVPRDD- 168 Query: 192 NDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVK 251 +LQL + S RK Y+ + Sbjct: 169 -------------------QAMFLQLCHRHLDASL----SARKRAAAGEAFARYLVAMMA 205 Query: 252 EHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYG 311 +D D + + E T + + L AG + S + G Sbjct: 206 RER--------KDPGDGFIGSIVAEHGDT---ITDEELRGVCVQLMLAGDDNVSGMIGLG 254 Query: 312 LLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHE 371 +L L+++PE L + D V E+ R++T+ + P Sbjct: 255 VLALLRHPEQIAALRGDDQS------------------ADRAVDELIRYLTVPYAPTPRT 296 Query: 372 ATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFS 431 A D + +I +G V+ +L D PD ++ + F Sbjct: 297 AVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTRTPVPHVA---------FG 347 Query: 432 TGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK 467 G C G L R++L + A+ + F L DP Sbjct: 348 HGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPA 383 >3TYW-A nrPDB Length = 417 Score = 172 bits (436), Expect = 3e-43, Method: Composition-based stats. Identities = 72/398 (18%), Positives = 132/398 (33%), Gaps = 69/398 (17%) Query: 79 VMHGYKAVKEALLD-------YKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLT 131 V+ Y V+E L D + F G+ R R I + P RR L Sbjct: 57 VVTRYDDVRELLSDPRVSADIRRPGFPALGEGEQEAGARFRPFIRTDAPEHTRYRRMLLP 116 Query: 132 TLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDY 191 + + +Q +L+ + G + +VI ++L D Sbjct: 117 AFTVRRV--RAMRPAVQARVDEILDGMLAAGGPVDLVSAYANAVSTSVICELLGIPRHD- 173 Query: 192 NDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVK 251 L+ + + + +V + + + + V Sbjct: 174 -----------------------LEFFRDVTRISGSRNSTAEQVSEALGGLFGLLGGLVA 210 Query: 252 EHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYG 311 E + + D L+ ++ + + T + + T+ AG ETT++ + Sbjct: 211 ERRE--------EPRDDLISKLVTDHLVPGNV-TTEQLLSTLGITINAGRETTTSMIALS 261 Query: 312 LLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHE 371 L+L+ PE+ +L ++ D M A V E+ R +++ S Sbjct: 262 TLLLLDRPELPAELRKDPD------------------LMPAAVDELLRVLSVADSIPLRV 303 Query: 372 ATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFS 431 A D G +P V+ L +D ++F DPE+ N + F Sbjct: 304 AAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHRTDN---------HHVAFG 354 Query: 432 TGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDI 469 G C G+ LAR+EL + L +L+ L +D Sbjct: 355 YGVHQCVGQHLARLELEVALETLLRRVPTLRLAGERDQ 392 >4YT3-A nrPDB Length = 410 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 83/390 (21%), Positives = 121/390 (31%), Gaps = 76/390 (19%) Query: 83 YKAVKEALLDYKDEFSGRGDLPAFHAHRDRG--------IIFNNGPTWKDIRRFSLTTLR 134 Y+ VK L DYK S R I ++ P + R Sbjct: 49 YEDVKRVLSDYKHFSSVRKRTTISVGTDSEEGSVPEKIQITESDPPDHRKRRSLLAAAFT 108 Query: 135 NYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPT-FLIGCAPCNVIADILFRKHFDYND 193 + Q E RIQ A L+ + G D L P V+AD++ D Sbjct: 109 PRSL--QNWEPRIQEIADELIGQMD--GGTEIDIVASLASPLPIIVMADLMGVPSKD--- 161 Query: 194 EKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIK----NVAEVKEYVSER 249 LL W+ FL + +V K E +Y+ Sbjct: 162 --------------RLLFKKWVDTL-----FLPFDREKQEEVDKLKQVAAKEYYQYLYPI 202 Query: 250 VKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLR 309 V + N D+ LL + ++T D + T + AG ETTS L Sbjct: 203 VVQKR----LNPADDIISDLL-----KSEVDGEMFTDDEVVRTTMLILGAGVETTSHLLA 253 Query: 310 YGLLILM-KYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNL 368 L+ E+ ++LHE + + V E+ RF L Sbjct: 254 NSFYSLLYDDKEVYQELHE------------------NLDLVPQAVEEMLRFR-FNLIKL 294 Query: 369 PHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFK 428 D G + +G VV + + D + F DP N+ Sbjct: 295 DRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHRPNNK--------KHL 346 Query: 429 PFSTGKRVCAGEGLARMELFLLLCAILQHF 458 F G C G LAR+E + L A L+ F Sbjct: 347 TFGNGPHFCLGAPLARLEAKIALTAFLKKF 376 >4MM0-A nrPDB Length = 399 Score = 171 bits (434), Expect = 5e-43, Method: Composition-based stats. Identities = 77/419 (18%), Positives = 131/419 (31%), Gaps = 70/419 (16%) Query: 74 SQRMVVMHGYKAVKEALLDYKDEFSGRGDLPA---FHAHRDRGIIFNNGPTWKDIRRFSL 130 ++ Y+ V+ L D FS R DLP ++ + P +RR Sbjct: 44 GDPGFLVTRYEDVRFVLSD--PRFSVRQDLPGAPRLTEMTFESVMTTDPPVHTRLRRLLS 101 Query: 131 TTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFD 190 + + R++ A LL+ + K L P VI ++L D Sbjct: 102 RDFTARRIERMR--PRLEEIAEGLLDEMEKKGAPADIVESLAVPFPITVICELLGVPMVD 159 Query: 191 YNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERV 250 +F W + S+L L + R Sbjct: 160 V--ARFRGWADTMVSLTGYSMEDWTAARDALESYLDGLVAAKR----------------- 200 Query: 251 KEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRY 310 N DL L+ ++ T + L AG E S L Sbjct: 201 --------ENPGSDLLSALVATAAEDNE-----LTDHDVRSLSLILLLAGYEPASNQLGS 247 Query: 311 GLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPH 370 +L L+++P+ +L R++ + + V E+ R+ L Sbjct: 248 SVLTLLRFPDRLAEL------------------RRDPGLLPSAVEELMRYAPAGDGALFR 289 Query: 371 EATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPF 430 D IP + V+ + + +D + F DP + + N++ Sbjct: 290 VTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTGLRLDRPDNQHTAL--------- 340 Query: 431 STGKRVCAGEGLARMELFLLLCAILQHFN-LKPLVDPKDIDLS---PIHIGFGCIPPRY 485 G C G LAR+EL + + A+L+ F L D + S + GF IP + Sbjct: 341 GHGIHFCLGAALARVELQVAIGALLRRFPRLALATDESGLRWSSPGSMLSGFAEIPVTW 399 >1LG9-A nrPDB Length = 398 Score = 171 bits (434), Expect = 5e-43, Method: Composition-based stats. Identities = 61/397 (15%), Positives = 120/397 (30%), Gaps = 75/397 (18%) Query: 81 HGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFN----------NGPTWKDIRRFSL 130 + V++ + D++ FS R +GI + P +RR Sbjct: 46 TAHAVVRQVMGDHQQ-FSTRRRWDPRDEIGGKGIFRPRELVGNLMDYDPPEHTRLRRKLT 104 Query: 131 TTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFD 190 M + I++ + L+ + + F+ P V+ +++ D Sbjct: 105 PGFTLRKMQRMA--PYIEQIVNDRLDEMERAGSPADLIAFVADKVPGAVLCELVGVPRDD 162 Query: 191 YNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERV 250 + F L L S ++ + Y+ + Sbjct: 163 -------------RDMFMKLCHGHLDASL-----------SQKRRAALGDKFSRYLLAMI 198 Query: 251 KEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRY 310 ++ + ++ + E T + + + AG + S + Sbjct: 199 ARER--------KEPGEGMIGAVVAEYGDDA---TDEELRGFCVQVMLAGDDNISGMIGL 247 Query: 311 GLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPH 370 G+L ++++PE + + V E+ R++T+ S P Sbjct: 248 GVLAMLRHPEQIDAFRGDEQS------------------AQRAVDELIRYLTVPYSPTPR 289 Query: 371 EATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPF 430 A D G I KG V+ +L + D PD ++ + F Sbjct: 290 IAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTREPIPHVA---------F 340 Query: 431 STGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK 467 G C G LAR+EL + + + F L DP Sbjct: 341 GHGVHHCLGAALARLELRTVFTELWRRFPALRLADPA 377 >4JBT-A nrPDB Length = 410 Score = 171 bits (432), Expect = 8e-43, Method: Composition-based stats. Identities = 77/421 (18%), Positives = 133/421 (31%), Gaps = 77/421 (18%) Query: 65 GPVFTLYVGSQRMVVMHGYKAVKEALLDY-----------KDEFSGRGDLPAFHAHR-DR 112 GP+ + + + + G+ ++ L D + P DR Sbjct: 30 GPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDINAWSLWQSGTVTRQWPLIGMIDVDR 89 Query: 113 GIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKT--QGQPFDPTF 170 + +GP + +R TT + I+R LL+ L + G D Sbjct: 90 SMFTVDGPEHRRLR--IKTTQALTRRRLDALKPTIERYVAELLDDLERAGADGAVVDLKS 147 Query: 171 LIGC-APCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLP 229 + P VI+ ++ D +L+ + F +L+ Sbjct: 148 VFAYPLPMRVISALMGVPSEDQE-----QLLTWYKAFFSILT------------------ 184 Query: 230 GSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGI 289 + ++ + E+ Y +E V+ DLT L+ E T + + Sbjct: 185 -PQDERLRVIDEMHGYFTEMVRRKTA----EPGDDLTSALIYAT-----DGETPLTEEEV 234 Query: 290 TVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPY 349 + L AG ETT + + + L+ +PE + D IG Sbjct: 235 IGNLQALVAAGHETTVSLILTAVRALLSHPEQLRLVR---DGEIG--------------- 276 Query: 350 MDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF-PDPEK 408 + + E R+ V L AT D +IP+G VV + ++ D D + Sbjct: 277 WETAIEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVHGADADD 336 Query: 409 FKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKD 468 F F G +C G LAR+E + L A+ F P D Sbjct: 337 FDITRATAAR--------HISFGHGPHICPGAALARLEAAIALPALFTRFPHLHPALPLD 388 Query: 469 I 469 Sbjct: 389 Q 389 >5FOI-A nrPDB Length = 408 Score = 171 bits (432), Expect = 8e-43, Method: Composition-based stats. Identities = 81/434 (18%), Positives = 144/434 (33%), Gaps = 72/434 (16%) Query: 53 IPKSFTRLAQRFGPV-FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRD 111 +P+ + QR V ++ GS ++ Y+ V+ L+D + A D Sbjct: 34 LPEQYAEFRQRATLVPAKVWDGS-PTWLVSRYEHVRALLVDPRVTVDPTRQPRLSEADGD 92 Query: 112 ----RGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFD 167 R ++ + P +RR ++ + E I++ +L+ L + Sbjct: 93 GDGFRSMLMLDPPEHTRLRRMFISAFSVRQVETMRPE--IEKIVDGILDRLLALEPPVDI 150 Query: 168 PTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHY 227 T L VI +L Y D +F F E L S P Sbjct: 151 LTHLALPMSTQVICHLLGVP---YEDREF------FQERSELASRPNDD----------- 190 Query: 228 LPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMD 287 + + + E+ EY+ V+ D LL E+ + T Sbjct: 191 ------RSMPALIELVEYLDGLVRTKTAHPD--------TGLLGTAVTERLLKGEI-THQ 235 Query: 288 GITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEM 347 + L AG ET++ + +L L+++PE +L E + Sbjct: 236 ELVNNAVLLLAAGHETSANQVTLSVLTLLRHPETAAELRE------------------QP 277 Query: 348 PYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE 407 M V E+ R+ ++ L AT D + + I G ++ L S +D F Sbjct: 278 ELMPNAVDELLRYHSIA-DGLRRAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEA 336 Query: 408 KFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLV-DP 466 F + + F G C G+ LAR+E+ + L + + L +P Sbjct: 337 TFDIHR---------PARHHVAFGYGPHQCLGQNLARLEMEVTLGKLFRRVPALRLAQEP 387 Query: 467 KDIDLSPIHIGFGC 480 + + FG Sbjct: 388 DALRVRQGSPIFGI 401 >3ABA-A nrPDB Length = 403 Score = 171 bits (432), Expect = 9e-43, Method: Composition-based stats. Identities = 68/415 (16%), Positives = 127/415 (30%), Gaps = 72/415 (17%) Query: 80 MHGYKAVKEALLDYKDEFSGRG------DLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTL 133 + GY+ V+ ALL D +++ + P R+ Sbjct: 48 VTGYEEVR-ALLRDSSFSVQVPHALHTQDGVVTQKPGRGSLLWQDEPEHTSDRKLLAKEF 106 Query: 134 RNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYND 193 M Q IQR L+A+ + +G P D A +++ LF Sbjct: 107 TVRRM--QALRPNIQRIVDEHLDAI-EARGGPVDLVKTFANAVPSMVISDLFG------- 156 Query: 194 EKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEH 253 + + + + + + + + V+E Sbjct: 157 ----------------VPVERRAEFQDIAEAMMRVDQDAAATEAAGMRLGGLLYQLVQER 200 Query: 254 HQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLL 313 N DL L+ + + + L A +TT+ + G Sbjct: 201 RA----NPGDDLISALIT-----TEDPDGVVDDMFLMNAAGTLLIAAHDTTACMIGLGTA 251 Query: 314 ILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEAT 373 +L+ P+ L E+ + V E+ R++T+ AT Sbjct: 252 LLLDSPDQLALLRED------------------PSLVGNAVEELLRYLTIGQFGGERVAT 293 Query: 374 RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTG 433 RD G I KG VV + + +D +PE+F + F G Sbjct: 294 RDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITRRPAPH---------LAFGFG 344 Query: 434 KRVCAGEGLARMELFLLLCAILQHFNLKPLVDP-KDIDLSPIHIGFGC--IPPRY 485 C G+ LAR+EL ++ + + L P +++ + +G +P + Sbjct: 345 AHQCIGQQLARIELQIVFETLFRRLPGLRLAKPVEELRFRHDMVFYGVHELPVTW 399 >3R9C-A nrPDB Length = 418 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 74/385 (19%), Positives = 117/385 (30%), Gaps = 59/385 (15%) Query: 101 GDLPAFHAHRDRG---IIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEA 157 L A R +G +F + P +R + E I LL+A Sbjct: 81 RQLAAETQPRPQGPASFLFLDPPDHTRLRGLVSKAFA--PRVIKRLEPEITALVDQLLDA 138 Query: 158 LRKTQGQPFDPTF-LIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQ 216 + G F+ L P VI +L D KF R L + Sbjct: 139 V---DGPEFNLIDNLAYPLPVAVICRLLGVPIEDE--PKFSRASALLAAALDPFLALTGE 193 Query: 217 LYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKE 276 + F + +K +++Y+ + E ++ DL L+ E Sbjct: 194 TSDLFD-----------EQMKAGMWLRDYLRALIDERRRT----PGEDLMSGLVAVEESG 238 Query: 277 KHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPS 336 T D I T L AG ETT + L +++ P L + R Sbjct: 239 DQ-----LTEDEIIATCNLLLIAGHETTVNLIANAALAMLRTPGQWAALAADGSR----- 288 Query: 337 RIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSV 396 AV+ E R+ V + A D + +PKG ++ L + Sbjct: 289 -------------ASAVIEETMRYDPPVQL-VSRYAGDDLTIGTHTVPKGDTMLLLLAAA 334 Query: 397 LYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQ 456 D P++F P+ F G C G LAR+E + L A+ Sbjct: 335 HRDPTIVGAPDRFDPDR---------AQIRHLGFGKGAHFCLGAPLARLEATVALPALAA 385 Query: 457 HFNLKPLVDPKDIDLSPIHIGFGCI 481 F L + + G + Sbjct: 386 RFPEARLSGEPEYKRNLTLRGMSTL 410 >6A7I-A nrPDB Length = 411 Score = 169 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 79/372 (21%), Positives = 136/372 (36%), Gaps = 66/372 (17%) Query: 107 HAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQ-GQP 165 A+ R ++ +G + +R L + + I+ + LE L G+P Sbjct: 81 LANPGRSMLTVDGADHRRLRTLVAQALTV--KRVERLRAGIEALTNASLEKLAALPAGEP 138 Query: 166 FDPTFLIGC-APCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSF 224 D P NVI++++ D+ RL LF + F + P Sbjct: 139 VDLKAEFAYPLPMNVISELMGVDAADHP-----RLKELFEKFFSTQTPPE---------- 183 Query: 225 LHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLY 284 +V + +A++ ++ V N DLT L+ E H Sbjct: 184 ---------EVPQMMADLGALFTKIVDAKRT----NPGDDLTSALIAASENGDH-----L 225 Query: 285 TMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDR 344 T + I T+ + AG ETT + + + L +PE +K+ ++ IG Sbjct: 226 TDEEIVNTLQLIIAAGHETTISLIVNVVEALQTHPEQRKKV---LNGEIG---------- 272 Query: 345 QEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF- 403 D V+ E R+ T L AT D ++PKG ++ + ++ D +++ Sbjct: 273 -----WDGVIEETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGALGRDEEQYG 327 Query: 404 PDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL 463 P +F N + F G VC G L+R+E + L A+ + F L Sbjct: 328 PTAGEFDATRTPNRHIA---------FGHGPHVCPGAALSRLEAGIALPALYERFPELDL 378 Query: 464 VDPK-DIDLSPI 474 P D+ PI Sbjct: 379 AVPASDLRNKPI 390 >6M7L-A nrPDB Length = 404 Score = 167 bits (423), Expect = 9e-42, Method: Composition-based stats. Identities = 79/437 (18%), Positives = 135/437 (30%), Gaps = 83/437 (18%) Query: 45 LFQLELKNIPKSFTRLAQRFGPVFTLYV--GSQRMVVMHGYKAVKEALLDYKDEFSGRGD 102 + L + + +L GP+ + + GS GY V+E L E + Sbjct: 28 VLHLRDRLDLAAELKLLCERGPLVRIPLEDGSAVHWFALGYDVVREVL---GSEKFDKRV 84 Query: 103 LPAFHAHRDRGI----IFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEAL 158 + H++ + + + P +RR M Q E R+Q L+ + Sbjct: 85 IGTHFNHQEMALPGNLLQLDPPEHTRLRRMVAPAYSVRRM--QALEPRVQAIVDDHLDTM 142 Query: 159 RKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLY 218 T + G V + L D E L + Sbjct: 143 ASTGPPVEFLREVAGPMAARVACEFLGIPLDDRG------------ELIRLTAH------ 184 Query: 219 NNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKH 278 G R+ + N Y+ E RD D +L + ++ Sbjct: 185 ----------RGGKRRRVLNGHAYLAYMRELAARLR--------RDPGDGMLGMVARDHG 226 Query: 279 SAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRI 338 + + + + A + + E T + L G L+L+++PE L E Sbjct: 227 AD---ISDEELAGLCAVVMNSSVEQTESCLAAGTLLLLEHPEQFALLRE----------- 272 Query: 339 PAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLY 398 + V EI R++++ P AT D G +I KG V +L + Sbjct: 273 -------RPELGEQAVEEIVRYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAANR 325 Query: 399 -DNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQH 457 D + F + + F G C G LARMEL + ++ Sbjct: 326 ADPAL----DGFDITRKESRHVA---------FGHGIHHCLGAPLARMELRIAFTTLVSR 372 Query: 458 FNLKPLVDP-KDIDLSP 473 F P ++I P Sbjct: 373 FPSLRTAVPAEEIRFRP 389 >6GK6-A nrPDB Length = 411 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 72/377 (19%), Positives = 121/377 (32%), Gaps = 63/377 (16%) Query: 109 HRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDP 168 D+ ++ + P +R +G RIQ A L++A+ + + Sbjct: 86 FMDQHMLDADPPDHTRLRAIVQRAFS--PRMMEGLRPRIQEIADGLIDAVIDRR-RMELI 142 Query: 169 TFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYL 228 P VIA + L L F + + Sbjct: 143 ADFAFPLPTAVIA-------------ELLGLPVEDRGRFRRWTK------------ILLA 177 Query: 229 PGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDG 288 P R+ ++ V E + + + DL LL+ E+E + Sbjct: 178 PAKDREFVERAQPVVEEFAAYFRALADARRKAPRDDLISGLLLAEEQEHK-----LSPAE 232 Query: 289 ITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMP 348 ++ V L AG ETT + G+L+L+ +P +L E+ Sbjct: 233 LSSMVFLLLVAGHETTVHLIASGMLLLLSHPAERRRLDED------------------PG 274 Query: 349 YMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEK 408 + + V E R + + D G +P G V L + D Q FPDP++ Sbjct: 275 LVGSAVEEALRCEGPAELSTIRWSLEDIELFGARVPAGEGVAAGLLAANRDPQHFPDPDR 334 Query: 409 FKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFN-LKPLVDPK 467 F N + F G C G LAR+E + +L+ ++ + Sbjct: 335 FDIGRSPNRH---------IGFGGGIHFCLGAMLARIEAAIAFSTLLRRLPRIELATSTR 385 Query: 468 DIDLS--PIHIGFGCIP 482 DI S P G +P Sbjct: 386 DIVWSEWPTIRGPAAVP 402 >1EHE-A nrPDB Length = 403 Score = 166 bits (419), Expect = 3e-41, Method: Composition-based stats. Identities = 60/367 (16%), Positives = 106/367 (28%), Gaps = 62/367 (16%) Query: 118 NGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRK--TQGQPFDPTFLIGCA 175 + P R T + + IQR LLE +++ P D Sbjct: 90 DPPEHMHQRSMVEPTFT--PEAVKNLQPYIQRTVDDLLEQMKQKGCANGPVDLVKEFALP 147 Query: 176 PCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKV 235 + I L F ND ++L N + R+ Sbjct: 148 VPSYIIYTLLGVPF--NDLEYLTQQNAIRTNGS---------------------STAREA 184 Query: 236 IKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVAD 295 E+ +Y++ V++ D+ L E K + Sbjct: 185 SAANQELLDYLAILVEQR----LVEPKDDIISKLCTEQVKPGN-----IDKSDAVQIAFL 235 Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L AG T + G+ L ++P+ +L V Sbjct: 236 LLVAGNATMVNMIALGVATLAQHPDQLAQLKA------------------NPSLAPQFVE 277 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E+ R+ T + A D + L+ ++ + S D + F +P++F Sbjct: 278 ELCRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNRKW 337 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDP-KDIDLSPI 474 F G C E LA+ EL + + Q F + P I+ +P+ Sbjct: 338 PPQDPLG-------FGFGDHRCIAEHLAKAELTTVFSTLYQKFPDLKVAVPLGKINYTPL 390 Query: 475 HIGFGCI 481 + G + Sbjct: 391 NRDVGIV 397 >3IVY-A nrPDB Length = 433 Score = 164 bits (416), Expect = 6e-41, Method: Composition-based stats. Identities = 97/473 (20%), Positives = 162/473 (34%), Gaps = 93/473 (19%) Query: 20 VSMWRQVHSSWNLPPG-PFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMV 78 +++ R S NLPPG F P I + F L P++ + G Sbjct: 10 IAVRRTTVPSPNLPPGFDFTDPAI-----YAERLPVAEFAELRSA-APIW--WNGQDPGK 61 Query: 79 ----------VMHGYKAVKEALLDYKDEFSG---------RGDLPAFHAHRDRGIIFN-N 118 + VKE + D FS + D+ R ++ N + Sbjct: 62 GGGFHDGGFWAITKLNDVKEI-SRHSDVFSSYENGVIPRFKNDIAREDIEVQRFVMLNMD 120 Query: 119 GPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCN 178 P +R+ +G+ +E +E + A G + P Sbjct: 121 APHHTRLRKIISRGFTPRAVGRLHDE---LQERAQKIAAEAAAAGSGDFVEQVSCELPLQ 177 Query: 179 VIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKN 238 IA +L D LF+ + + N P + H P + + Sbjct: 178 AIAGLLGVPQEDRG--------KLFHWSNEMTG-------NEDPEYAHIDPKA------S 216 Query: 239 VAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFF 298 AE+ Y + +E ++ D ++ ++ + E+L + D V L Sbjct: 217 SAELIGYAMKMAEEK--------AKNPADDIVTQLIQADIDGEKL-SDDEFGFFVVMLAV 267 Query: 299 AGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQ 358 AG ETT ++ G++ ++P+ E L++++ + EI Sbjct: 268 AGNETTRNSITQGMMAFAEHPDQWE-LYKKVRP-------------------ETAADEIV 307 Query: 359 RFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNEN 418 R+ T V + A RD G I KG VV S +D + F DP F N + Sbjct: 308 RWATPV-TAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPNPH 366 Query: 419 GKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF-NLKPLVDPKDID 470 F TG C G LARM + L+ A+ H +LKP+ P+ + Sbjct: 367 VGFG--------GTGAHYCIGANLARMTINLIFNAVADHMPDLKPISAPERLR 411 >5DQN-A nrPDB Length = 426 Score = 164 bits (416), Expect = 7e-41, Method: Composition-based stats. Identities = 81/402 (20%), Positives = 132/402 (32%), Gaps = 76/402 (18%) Query: 80 MHGYKAVKEALLDYKDEFSGRGD----LPAFHAHR-----DRGIIFN-NGPTWKDIRRFS 129 + + VKE D F D + R R ++ N + P +R+ Sbjct: 56 VTKHADVKEV-SRRSDVFGSSPDGAIPVYPQDMTREAVDLQRAVLLNMDAPQHTRLRKII 114 Query: 130 LTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGC-APCNVIADILFRKH 188 +G+ E ++ A + A D + C P IA++L Sbjct: 115 SRGFTPRAIGR--LEDELRSRAQKI--AQTAAAQGAGDFVEQVSCELPLQAIAELLGVPQ 170 Query: 189 FDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSE 248 D + LF + + + + + P+ + E+ Y + Sbjct: 171 DDRD--------KLFRWSNEMTAGEDPEYADVDPAMSSF-------------ELISYAMK 209 Query: 249 RVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTL 308 +E N D+ L+ E + D V L AG ETT ++ Sbjct: 210 MAEER----AVNPTEDIVTKLI-----EADIDGEKLSDDEFGFFVVMLAVAGNETTRNSI 260 Query: 309 RYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNL 368 +G++ + P+ E +E + EI R+ T V S Sbjct: 261 THGMIAFAQNPDQWELYKKE--------------------RPETAADEIVRWATPV-SAF 299 Query: 369 PHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFK 428 A D G I KG VV + S +D + F DP F N + F Sbjct: 300 QRTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNILRSPNPHVGFG------ 353 Query: 429 PFSTGKRVCAGEGLARMELFLLLCAILQHF-NLKPLVDPKDI 469 TG C G LARM + L+ AI + +LKP+ P+ + Sbjct: 354 --GTGAHYCIGANLARMTINLIFNAIADNMPDLKPIGAPERL 393 >5XJN-A nrPDB Length = 455 Score = 164 bits (414), Expect = 1e-40, Method: Composition-based stats. Identities = 77/453 (16%), Positives = 132/453 (29%), Gaps = 75/453 (16%) Query: 49 ELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSG--------R 100 ++ N ++ L Q +F +G V+ Y +K D + FS + Sbjct: 60 DMHNPFPAYKELRQEEPVMFDERIGYW---VVTKYDDIKTT-FDDWETFSSENAQAPVRK 115 Query: 101 GDLPAFHAHRDRGIIFNNG------PTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFL 154 A D G +G P IR + + E I+ Sbjct: 116 RGPQATQIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRY--KALEPDIRAMVIDR 173 Query: 155 LEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPW 214 +E + D + + L D + + W Sbjct: 174 VEKMLANDQHVGDMVSDLAYDIPTITILTLIGADISMVDT-------YKRWSDSRAAMTW 226 Query: 215 LQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEME 274 L + +P +H N+ E + V + H N DL Sbjct: 227 GDLSDE-----EQIPHAH-----NLVEYWQECQRMVADAHAHGGDNLTADLV-------- 268 Query: 275 KEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIG 334 + T I + L FAG ETT+T + +L+ +PE + + E Sbjct: 269 -RAQQEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILE------- 320 Query: 335 PSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLD 394 + A V E+ R+ + +A +DT G I +G V+ + Sbjct: 321 -----------NPKLIPAAVDEVLRYSGSI-VGWRRKALKDTEIGGVAIKEGDGVLLLMG 368 Query: 395 SVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAI 454 S D F + E+F + F G C G LA+++ + L + Sbjct: 369 SANRDEARFENGEEFDISR--------ANAREHLSFGFGIHYCLGNMLAKLQAKICLEEV 420 Query: 455 LQHFNLKPLVDPKDIDLSP--IHIGFGCIPPRY 485 + LV K I +P + Sbjct: 421 TRLVPSLHLVADKAIGFRENLSFRVPTSVPVTW 453 >3MGX-A nrPDB Length = 415 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 68/378 (17%), Positives = 121/378 (32%), Gaps = 67/378 (17%) Query: 110 RDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPT 169 R ++ + + +R+ + L + ++ E L L G+ D Sbjct: 102 GGRMMVVSEHEQHRKLRKL-VGPLLSRAAARKLAERVRIEVGDVLGRVL---DGEVCDAA 157 Query: 170 FLIG-CAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYL 228 IG P V+ +IL D + L + + F Sbjct: 158 TAIGPRIPAAVVCEILGVPAEDE------------DMLIDLTNHAFGGEDELFDGMTP-- 203 Query: 229 PGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDG 288 + E+ Y E + ++ D L+ + + T+D Sbjct: 204 -------RQAHTEILVYFDELITARR--------KEPGDDLVSTLVTDDD-----LTIDD 243 Query: 289 ITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMP 348 + + ++ G ETT + + L P + L + V Sbjct: 244 VLLNCDNVLIGGNETTRHAITGAVHALATVPGLLTALRDGSADV---------------- 287 Query: 349 YMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEK 408 D VV E+ R+ + ++ T D G +P GT VV L + D EF DP+ Sbjct: 288 --DTVVEEVLRWTSPA-MHVLRVTTADVTINGRDLPSGTPVVAWLPAANRDPAEFDDPDT 344 Query: 409 FKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKD 468 F P N + F G C G LAR+EL ++L + + + L Sbjct: 345 FLPGRKPNRHIT---------FGHGMHHCLGSALARIELSVVLRVLAERVSRVDLEREPA 395 Query: 469 IDLSPIHIGFGCIPPRYK 486 + + G+ +P R+ Sbjct: 396 WLRAIVVQGYRELPVRFT 413 >5GWE-A nrPDB Length = 405 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 77/453 (16%), Positives = 132/453 (29%), Gaps = 75/453 (16%) Query: 49 ELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSG--------R 100 ++ N ++ L Q +F +G V+ Y +K D + FS + Sbjct: 10 DMHNPFPAYKELRQEEPVMFDERIGYW---VVTKYDDIKTT-FDDWETFSSENAQAPVRK 65 Query: 101 GDLPAFHAHRDRGIIFNNG------PTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFL 154 A D G +G P IR + + E I+ Sbjct: 66 RGPQATQIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRY--KALEPDIRAMVIDR 123 Query: 155 LEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPW 214 +E + D + + L D + + W Sbjct: 124 VEKMLANDQHVGDMVSDLAYDIPTITILTLIGADISMVDT-------YKRWSDSRAAMTW 176 Query: 215 LQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEME 274 L + +P +H N+ E + V + H N DL Sbjct: 177 GDLSDE-----EQIPHAH-----NLVEYWQECQRMVADAHAHGGDNLTADLV-------- 218 Query: 275 KEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIG 334 + T I + L FAG ETT+T + +L+ +PE + + E Sbjct: 219 -RAQQEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILE------- 270 Query: 335 PSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLD 394 + A V E+ R+ + +A +DT G I +G V+ + Sbjct: 271 -----------NPKLIPAAVDEVLRYSGSI-VGWRRKALKDTEIGGVAIKEGDGVLLLMG 318 Query: 395 SVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAI 454 S D F + E+F + F G C G LA+++ + L + Sbjct: 319 SANRDEARFENGEEFDISR--------ANAREHLSFGFGIHYCLGNMLAKLQAKICLEEV 370 Query: 455 LQHFNLKPLVDPKDIDLSP--IHIGFGCIPPRY 485 + LV K I +P + Sbjct: 371 TRLVPSLHLVADKAIGFRENLSFRVPTSVPVTW 403 >3TKT-A nrPDB Length = 450 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 76/379 (20%), Positives = 138/379 (36%), Gaps = 54/379 (14%) Query: 113 GIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLI 172 ++ + P +RR + + + E I++ A+ ++ + + + Sbjct: 123 SLVQMDAPKHPKLRRLTQDWFMPKNLARLDGE--IRKIANEAIDRMLGAGEEGDFMALVA 180 Query: 173 GCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSH 232 P +V+ IL D ++++L + F Q + S L LP Sbjct: 181 APYPLHVVMQILGVPPEDEP-----KMLFLTQQMFG------GQDEDMNKSGLKDLPPEQ 229 Query: 233 --RKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGIT 290 + V VAE + Y + E R+ TD + + E + D Sbjct: 230 ISQIVAGAVAEFERYFAGLAAERR--------RNPTDDVATVIANAVVDGEPMSDRDTAG 281 Query: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350 + AG +TTS + L L + P++ ++ + + + Sbjct: 282 YYIIT-ASAGHDTTSASSAGAALALARDPDLFARVKADRN------------------LL 322 Query: 351 DAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410 +V E R+ T V + A DT G I G ++ + +D +FP+P KF Sbjct: 323 PGIVEEAIRWTTPVQ-HFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFD 381 Query: 411 PEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFN-LKPLVDPKDI 469 P N + F G C G LAR+E+ +LL +L + L+ +PK + Sbjct: 382 PTRPANRH---------LAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRV 432 Query: 470 DLSPIHIGFGCIPPRYKLC 488 + S GF +P R+K Sbjct: 433 N-STFVGGFKSLPMRWKAA 450 >3A1L-A nrPDB Length = 425 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 67/343 (19%), Positives = 106/343 (30%), Gaps = 57/343 (16%) Query: 114 IIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIG 173 ++F + P ++R T + G RI A LL+ LR + +P Sbjct: 98 LVFLDPPHHTELRSLLTTEFSPSIVT--GLRPRIAELASALLDRLRAQR-RPDLVEGFAA 154 Query: 174 CAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHR 233 P VI+ +L D+ + L + + Sbjct: 155 PLPILVISALLGIPEEDH-TWLRANAVALQEASTTRARDGRG----------------YA 197 Query: 234 KVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTV 293 + E Y V + + + ++DGI T Sbjct: 198 RAEAASQEFTRYFRREVDRRGGDDRDDL---------LTLLVRARDTGSPLSVDGIVGTC 248 Query: 294 ADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAV 353 L AG ETT+ L +L L + ++ ++L R A Sbjct: 249 VHLLTAGHETTTNFLAKAVLTLRAHRDVLDEL------------------RTTPESTPAA 290 Query: 354 VHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEH 413 V E+ R+ V + A D + IP+G+ VV L S D FPDP+ Sbjct: 291 VEELMRYDPPVQAVT-RWAYEDIRLGDHDIPRGSRVVALLGSANRDPARFPDPDVLDVHR 349 Query: 414 FLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQ 456 ++ F G C G LAR E + L A+L Sbjct: 350 ---------AAERQVGFGLGIHYCLGATLARAEAEIGLRALLD 383 >6F0B-A nrPDB Length = 395 Score = 162 bits (409), Expect = 4e-40, Method: Composition-based stats. Identities = 75/421 (17%), Positives = 129/421 (30%), Gaps = 71/421 (16%) Query: 74 SQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFN------NGPTWKDIRR 127 V GY+ V+ L D + R + + P + +R Sbjct: 37 GTPAHVFSGYEDVRTVLQDRRFSSDSRRPNFTELTPTLQSQAAAPPFVRTDNPDHRRLR- 95 Query: 128 FSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRK 187 + I+ +L+ L +T P D V + +FR Sbjct: 96 -GTIAREFLPKHIELLRPAIREIVQGVLDGLAET-APPQDMLEAFAVP---VASATVFR- 149 Query: 188 HFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVS 247 L + + GS + + + EY+ Sbjct: 150 --------LLGIPAEDRALLTRCVKGVVSAV-----------GSEDEGAEVFRTLGEYIG 190 Query: 248 ERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTT 307 V++ P +L + L+ E+ T + L G +TT++T Sbjct: 191 GLVQD---------PSELPEDSLIRRLVTGPYQEKQLTFHETIGVILMLIVGGYDTTAST 241 Query: 308 LRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSN 367 + L+ PE +HE P RIP + V E+ R+ T+ Sbjct: 242 ISLSLVSYALQPEKFSVVHE------HPERIPLL------------VEELLRYHTVSQLG 283 Query: 368 LPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYF 427 L AT D G + G +VV L D FP+P++ + S Sbjct: 284 LGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR---------PSVPH 334 Query: 428 KPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDP-KDIDLSPIHIGFGC--IPPR 484 F G C G+ LAR+EL + A+++ L +D+ +G +P Sbjct: 335 VGFGYGPHQCVGQALARVELQEAIPAVIRRLPGMRLACALEDLPFRHDMATYGIHELPMT 394 Query: 485 Y 485 + Sbjct: 395 W 395 >4XE3-A nrPDB Length = 407 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 76/446 (17%), Positives = 132/446 (29%), Gaps = 85/446 (19%) Query: 32 LPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYV--GSQRMVVMHGYKAVKEA 89 +P PF LP + L+ + R + PV + + G ++ + Sbjct: 14 VPAYPFSLP---HALDLD---PHYAELRRDE---PVSRVRLPYGEGTAWLVTRMSDARIV 64 Query: 90 LLDYKDEFSGRGDLPAFHAH----RDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNES 145 L D + + D G++ + P +RR + + Sbjct: 65 LGDSRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHTRLRRLVGKAFTARRVEEMR--P 122 Query: 146 RIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNE 205 R++ LL+ + FL P VI ++L D Sbjct: 123 RVRSLVDSLLDDMVAHGSPADLVEFLAVPFPVAVICELLGVPLEDR-------------- 168 Query: 206 NFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKE----YVSERVKEHHQSLDPNC 261 + F +F + S R + V++ Y+ V + Sbjct: 169 -------------DLFRTFSDAMLSSTRLTAAEIQRVQQDFMVYMDGLVAQRR----DAP 211 Query: 262 PRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEI 321 DL L + + + H T I L AG ET+ + + +L+ + Sbjct: 212 TEDLLGALALATDNDDH-----LTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLTERKR 266 Query: 322 EEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSN-LPHEATRDTIFRG 380 E L + + A V E+ R+ LV + AT D Sbjct: 267 YESL------------------VADPALVPAAVEEMLRYTPLVSAGSFVRVATEDVELST 308 Query: 381 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 440 + G V S D + F ++ N + F G C G Sbjct: 309 VTVRAGEPCVVHFASANRDEEVFDHADELDFHRERNPHIA---------FGHGAHHCIGA 359 Query: 441 GLARMELFLLLCAILQHFNLKPLVDP 466 L R+EL L A+++ F L +P Sbjct: 360 QLGRLELQEALSALVRRFPTLDLAEP 385 >5DE9-A nrPDB Length = 410 Score = 159 bits (402), Expect = 3e-39, Method: Composition-based stats. Identities = 76/416 (18%), Positives = 134/416 (32%), Gaps = 81/416 (19%) Query: 78 VVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYG 137 +V + + +EA++D + L + F + P +RR G Sbjct: 62 LVTNDPRFGREAVMDRQV-----TRLAPHFRPARGAVGFLDPPDHTRLRRSVAAAFTARG 116 Query: 138 MGKQGNESRIQREAHFLLEALRKTQ---GQPFDPTF-LIGCAPCNVIADILFRKHFDYND 193 + R++ + +L+ L G P D T ++ P VI +++ D + Sbjct: 117 V------ERVRERSRGMLDELVDAMLRAGPPADLTEAVLSPFPIAVICELMGVPATDRHS 170 Query: 194 EKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEH 253 W QL + + E+ Y S+ + Sbjct: 171 -----------------MHTWTQLILSSSHGAEVSE-------RAKNEMNAYFSDLIGLR 206 Query: 254 HQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLL 313 + D+T L + +++ T+ L G E + Sbjct: 207 ----SDSAGEDVTSLLGAAVGRDE------ITLSEAVGLAVLLQIGG-EAVTNNSGQMFH 255 Query: 314 ILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS-NLPHEA 372 +L+ PE+ E+L E + E+ R+I + L A Sbjct: 256 LLLSRPELAERLRSE------------------PEIRPRAIDELLRWIPHRNAVGLSRIA 297 Query: 373 TRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFST 432 D +G I G V + + D + FPDP++ E N + F Sbjct: 298 LEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFERSPNPHVS---------FGF 348 Query: 433 GKRVCAGEGLARMELFLLLCAILQHFN-LKPLVDPKDIDLS--PIHIGFGCIPPRY 485 G C G LAR+E LL+ A+L LK V P+D+ + G +P + Sbjct: 349 GPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDVPFKKGALIRGPEALPVTW 404 >1ODO-A nrPDB Length = 408 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 65/375 (17%), Positives = 119/375 (31%), Gaps = 65/375 (17%) Query: 114 IIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQ-GQPFDPTFLI 172 + GP + +RR + ++ L++ L + G+P D + Sbjct: 87 MFTAYGPNHRKLRRLVAPAFSARRV--DAMRPAVEAMVTGLVDRLAELPAGEPVDLRQEL 144 Query: 173 GC-APCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGS 231 P VI ++ + + F L + Sbjct: 145 AYPLPIAVIGHLM-------------GVPQDRRDGFRALVDGVFDTTLD----------- 180 Query: 232 HRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITV 291 + N A + E + + + + P D LL+ ++ +RL + + + Sbjct: 181 QAEAQANTARLYEVLDQLIAAKRAT-----PGDDMTSLLIAARDDEGDGDRL-SPEELRD 234 Query: 292 TVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMD 351 T+ + AG ETT + + L+ P+ + + E+ + D Sbjct: 235 TLLLMISAGYETTVNVIDQAVHTLLTRPDQLALVRK-----------------GEVTWAD 277 Query: 352 AVVHEIQRFITLVPSNLPHEATRDTIF-RGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410 VV E R V A D G I +G ++ + + D + F Sbjct: 278 -VVEETLRHEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADTFD 336 Query: 411 PEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDP-KDI 469 + E+ F G C G LARME+ L L ++ F L DP +++ Sbjct: 337 ATRTVKEH---------LAFGHGVHFCLGAPLARMEVTLALESLFGRFPDLRLADPAEEL 387 Query: 470 DLSP--IHIGFGCIP 482 P I G +P Sbjct: 388 PPVPSLISNGHQRLP 402 >5LIV-A nrPDB Length = 450 Score = 158 bits (400), Expect = 4e-39, Method: Composition-based stats. Identities = 71/391 (18%), Positives = 122/391 (31%), Gaps = 66/391 (16%) Query: 89 ALLDYKDEFSGRGDLPAF------HAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQG 142 LL + D F + G+ G +RR Q Sbjct: 92 ILLRKSHITTAYRDTATFSTRMFQAGILNGGLAAMQGDEHARMRR-VYNMFFLPRAVSQY 150 Query: 143 NESRIQREAHFLLEALRKTQGQP-FDPTFLIGC-APCNVIADILFRKHFDYNDEKFLRLM 200 E ++ + +++ L G+P D P VI ++ F + E R+ Sbjct: 151 EERFVRPISEQVVDRL---AGKPRVDLLEDFAMELPRRVIGEL-FGFPAEKLHETDERVR 206 Query: 201 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 260 + + + P + + + E ++E V+ Sbjct: 207 AMLRGLVRM-----------------HDPAAVAESQRAYGETLGLITEVVER-------- 241 Query: 261 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 320 RD +D LL E+ + AE + T++ V L G ETTS + + L+ +P+ Sbjct: 242 ESRDTSDTLLGEILR-TLKAEHMDTIEASRQIVLSLILGGYETTSWLVANTIHALLAHPD 300 Query: 321 IEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRG 380 ++ ++ + A + E R+ + RD Sbjct: 301 TLARVRQD------------------PSLLPAAIEEGMRWCP-SSFGVLRMVERDVRLDD 341 Query: 381 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 440 + GTVV + YD +P PE + + K F G C G Sbjct: 342 QALSAGTVVCLAGIAGNYDETAYPSPEVYDIDR--------KPLPAANVFGGGAHFCVGA 393 Query: 441 GLARMELFLLLCAILQHFNLKPLVDPKDIDL 471 LARME + L A+L F V + Sbjct: 394 PLARMEARVGLQALLARFPGLRAVPEERPSF 424 >6F88-A nrPDB Length = 400 Score = 158 bits (400), Expect = 5e-39, Method: Composition-based stats. Identities = 71/391 (18%), Positives = 122/391 (31%), Gaps = 66/391 (16%) Query: 89 ALLDYKDEFSGRGDLPAF------HAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQG 142 LL + D F + G+ G +RR Q Sbjct: 42 ILLRKSHITTAYRDTATFSTRMFQAGILNGGLAAMQGDEHARMRR-VYNMFFLPRAVSQY 100 Query: 143 NESRIQREAHFLLEALRKTQGQP-FDPTFLIGC-APCNVIADILFRKHFDYNDEKFLRLM 200 E ++ + +++ L G+P D P VI ++ F + E R+ Sbjct: 101 EERFVRPISEQVVDRL---AGKPRVDLLEDFAMELPRRVIGEL-FGFPAEKLHETDERVR 156 Query: 201 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 260 + + + P + + + E ++E V+ Sbjct: 157 AMLRGLVRM-----------------HDPAAVAESQRAYGETLGLITEVVER-------- 191 Query: 261 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 320 RD +D LL E+ + AE + T++ V L G ETTS + + L+ +P+ Sbjct: 192 ESRDTSDTLLGEILR-TLKAEHMDTIEASRQIVLSLILGGYETTSWLVANTIHALLAHPD 250 Query: 321 IEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRG 380 ++ ++ + A + E R+ + RD Sbjct: 251 TLARVRQD------------------PSLLPAAIEEGMRWCP-SNFGVLRMVERDVRLDD 291 Query: 381 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 440 + GTVV + YD +P PE + + K F G C G Sbjct: 292 QALSAGTVVCLAGIAGNYDETAYPSPEVYDIDR--------KPLPAANVFGGGAHFCVGA 343 Query: 441 GLARMELFLLLCAILQHFNLKPLVDPKDIDL 471 LARME + L A+L F V + Sbjct: 344 PLARMEARVGLQALLARFPGLRAVPEERPSF 374 >4Z5Q-A nrPDB Length = 423 Score = 158 bits (399), Expect = 6e-39, Method: Composition-based stats. Identities = 79/460 (17%), Positives = 148/460 (32%), Gaps = 78/460 (16%) Query: 17 LLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYV-GSQ 75 L SM +V + P P P G+ E + +S+ +L + G + + + Sbjct: 19 LYFQSMSTEVETEK---PAPVAYPFTGS----EGLELSQSYAKLFED-GDPIRVQLPFGE 70 Query: 76 RMVVMHGYKAVKEALLDYKDEFS-----GRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSL 130 ++ Y + L D FS R + I+ + P +R Sbjct: 71 PAWLVTRYDDARFVLTD--RRFSRHLATQRDEPRMTPRAVPESILTMDPPDHTRLRTLVS 128 Query: 131 TTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFD 190 + + + I A L+ ++ P VI ++L D Sbjct: 129 KAFTPRRIESKR--AWIGELAAGLVADMKAGGAPAELVGSYALAIPVTVICELLGVPEDD 186 Query: 191 YNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERV 250 L LST L + + +++ ++++Y + V Sbjct: 187 RT--------RLRGWCDAALSTGEL---------------TDEECVQSFMDLQKYFEDLV 223 Query: 251 KEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRY 310 KE DLT L+ + AE + + G ETT++ + Sbjct: 224 KERRA----EPRDDLTSALIEARDAHDRLAEP-----ELIGLCISILIGGFETTASEISS 274 Query: 311 GLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNL-P 369 + +L + E+ +L + + + A V E+ RF+ + + P Sbjct: 275 FVHVLQQRRELWTRLCADPEAI------------------PAAVEELLRFVPFAANGISP 316 Query: 370 HEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKP 429 A D G L+ +G V+ +V D F + ++ + N + Sbjct: 317 RYALEDMTVGGVLVREGEPVIVDTSAVNRDGLVFDNADEVVIDRADNRH---------MV 367 Query: 430 FSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDI 469 F G C G LAR+EL L A+++ L + Sbjct: 368 FGHGAHHCLGAHLARVELQEALKALVEGMPGLRLSGDVEW 407 >2RFC-A nrPDB Length = 343 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 73/382 (19%), Positives = 120/382 (31%), Gaps = 81/382 (21%) Query: 79 VMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFN--NGPTWKDIRRFSLTTLRNY 136 ++ Y VK L++ K S G+ + GI F + P K+ R S Sbjct: 14 HVYKYSDVKHVLMNDKIFSSNPGNRYS----NAGGISFITMDNPEHKEFRDISAPYFLPS 69 Query: 137 GMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKF 196 + I+ ++ L++ + + P N+I+ IL D Sbjct: 70 KINDYK--DFIEETSNDLIKNIDNKD----IISEYAVRLPVNIISKILGIPDSDM----- 118 Query: 197 LRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQS 256 F + Y+ G K +N V + R+ E +S Sbjct: 119 ----------------------PLFKLWSDYIIG--NKRDENFNYVNNRMVSRLLEIFKS 154 Query: 257 LDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILM 316 + + L K R TMD + L G ETT+ + + ++ Sbjct: 155 DSHG----IINVLAGSSLK-----NRKLTMDEKIKYIMLLIIGGNETTTNLIGNMIRVID 205 Query: 317 KYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDT 376 + P+I + + V E R+ + + A D+ Sbjct: 206 ENPDIID---------------------DALKNRSGFVEETLRYYSPIQFLPHRFAAEDS 244 Query: 377 IFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRV 436 I KG V+ L S D F +P+ FK + F G + Sbjct: 245 YINNKKIKKGDQVIVYLGSANRDETFFDEPDLFKIGRR----------EMHLAFGIGIHM 294 Query: 437 CAGEGLARMELFLLLCAILQHF 458 C G LAR+E + L IL HF Sbjct: 295 CLGAPLARLEASIALNDILNHF 316 >3P3Z-A nrPDB Length = 416 Score = 156 bits (395), Expect = 2e-38, Method: Composition-based stats. Identities = 67/383 (17%), Positives = 111/383 (28%), Gaps = 59/383 (15%) Query: 105 AFHAHRDRGIIFNNGPTWKDIRRFS-LTTLRNYGMGKQGNESRIQREAHFLLEALRKTQG 163 RD + F D RR L T + ++ L++ L Sbjct: 88 PEGPVRDFMVDFLQSLDGADHRRLRGLATHPFTPRRITAVQPFVRSTVEQLIDKL---PQ 144 Query: 164 QPFDPTFLI-GCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFP 222 FD P V+ +L DY+ L + N Sbjct: 145 GDFDFVQHFPHPLPALVMCQLLGFPLEDYDT------------------VGRLSIETNLG 186 Query: 223 SFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAER 282 L KV + + + +Y+ +++ + D L ++ + H Sbjct: 187 LALSNDQDILVKVEQGLGRMFDYLVAAIEKRKV--------EPGDDLTSDIVRAFHDG-- 236 Query: 283 LYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIK 342 + + VA + AG ETT+ L + ++P+ K+ E Sbjct: 237 VLDDYELRTLVATVLVAGYETTNHQLALAMYDFAQHPDQWMKIKE--------------- 281 Query: 343 DRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQE 402 V E+ R+ +P A D G IP GT V D + Sbjct: 282 ---NPELAPQAVEEVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRV 338 Query: 403 FPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKP 462 F D ++F K F G C G LAR+EL + A+ + Sbjct: 339 FADADRFDIT--------VKREAPSIAFGGGPHFCLGTALARLELTEAVAALATRLDPPQ 390 Query: 463 LVDPKDIDLSPIHIGFGCIPPRY 485 + G +P R+ Sbjct: 391 IAGEITWRHELGVAGPDALPLRF 413 >3NC3-A nrPDB Length = 441 Score = 156 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 78/442 (17%), Positives = 143/442 (32%), Gaps = 57/442 (12%) Query: 44 NLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDL 103 ++ + +N P ++ + PV Y S + Y V+ L + D F+ + + Sbjct: 45 SVLSDQFQNNPYAYFSQLREEDPVH--YEESIDSYFISRYHDVRYIL-QHPDIFTTKSLV 101 Query: 104 P-AFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQ 162 A R + +G RR + + G I++ A LL + + Sbjct: 102 ERAEPVMRGPVLAQMHGKEHSAKRRIVVRSF--IGDALDHLSPLIKQNAENLLAPYLE-R 158 Query: 163 GQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFP 222 G+ V D+L D+ + W +F Sbjct: 159 GKSDLVNDFGKTFAVCVTMDMLGLDKRDHEK-----------------ISEWHSGVADFI 201 Query: 223 SFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAER 282 + + P + + ++ +Y+ +KE N DL L ++ Sbjct: 202 TSISQSPEARAHSLWCSEQLSQYLMPVIKERRV----NPGSDLISILCT----SEYEGMA 253 Query: 283 LYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIK 342 L D I + ++ A TE TL + L+ PE + + Sbjct: 254 LSDKD-ILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDV---------------LA 297 Query: 343 DRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQE 402 DR +P + E R+ V +P + ++DT+ G I K T+V + + D + Sbjct: 298 DRSLVP---RAIAETLRYKPPVQL-IPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEA 353 Query: 403 FPDPEKFKPEH-FLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 461 F P+ F L F + F +G C G A+ E+ ++ +L Sbjct: 354 FEQPDVFNIHREDLGIKSAFSGAARHLAFGSGIHNCVGTAFAKNEIEIVANIVLDKMRNI 413 Query: 462 PLVDPKDIDLSPIHIGFGCIPP 483 L + D G P Sbjct: 414 RLEE----DFCYAESGLYTRGP 431 >1GWI-A nrPDB Length = 411 Score = 156 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 83/419 (19%), Positives = 136/419 (32%), Gaps = 79/419 (18%) Query: 65 GPVFTLYV-GSQRMVVMHGYKAVKEALLDYKDEFSG--------RGDLPAF-----HAHR 110 GP+ + + G + + + K ALL RG++PA A+ Sbjct: 30 GPLAAVELPGGVPVWAVTHHAEAK-ALLTDPRLVKDINVWGAWRRGEIPADWPLIGLANP 88 Query: 111 DRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTF 170 R ++ +G + +R L + RI LL+ L G D Sbjct: 89 GRSMLTVDGAEHRRLRTLVAQALTVRRVEHMR--GRITELTDRLLDEL-PADGGVVDLKA 145 Query: 171 LIGC-APCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLP 229 P V+AD++ + + RL LF + F + P Sbjct: 146 AFAYPLPMYVVADLMGI-----EEARLPRLKVLFEKFFSTQTPPE--------------- 185 Query: 230 GSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGI 289 +V+ + E+ +++ V + DLT L+ E H T I Sbjct: 186 ----EVVATLTELASIMTDTVAAKRAA----PGDDLTSALIQASENGDH-----LTDAEI 232 Query: 290 TVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPY 349 T+ + AG ETT + + ++ L +PE + Sbjct: 233 VSTLQLMVAAGHETTISLIVNAVVNLSTHPEQRALV------------------LSGEAE 274 Query: 350 MDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF-PDPEK 408 AVV E RF T L A D +IP G ++ + ++ D + P ++ Sbjct: 275 WSAVVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADR 334 Query: 409 FKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK 467 F + F G VC G L+RME + L A+ F L P Sbjct: 335 FDLTRTS--------GNRHISFGHGPHVCPGAALSRMEAGVALPALYARFPHLDLAVPA 385 >1F4U-A nrPDB Length = 368 Score = 154 bits (388), Expect = 1e-37, Method: Composition-based stats. Identities = 69/429 (16%), Positives = 137/429 (31%), Gaps = 90/429 (20%) Query: 53 IPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSG-----------RG 101 + F+ + ++ PV+ Y G+ V Y+ KE L ++ S R Sbjct: 1 MYDWFSEMRKK-DPVY--YDGNIWQVF--SYRYTKEVLNNFSKFSSDLTGYHERLEDLRN 55 Query: 102 DLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKT 161 F ++ ++ P ++R S + Q E+ I+ LL+++ Sbjct: 56 GKIRFDIPTRYTMLTSDPPLHDELRSMSADIFSPQKL--QTLETFIRETTRSLLDSID-- 111 Query: 162 QGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNF 221 + L P VI+ IL D + +++ Sbjct: 112 PREDDIVKKLAVPLPIIVISKILGLPIEDKEK---------------------FKEWSDL 150 Query: 222 PSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAE 281 +F PG ++ K E+ YV + + + Sbjct: 151 VAFRLGKPGEIFELGKKYLELIGYVKDHLNS------------------GTEVVSRVVNS 192 Query: 282 RLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAI 341 L ++ + + L AG ETT+ + ++ ++ + +++ EE Sbjct: 193 NLSDIEKLGYIIL-LLIAGNETTTNLISNSVIDFTRF-NLWQRIREE------------- 237 Query: 342 KDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQ 401 + E R+ V + + I +G V + S D + Sbjct: 238 ------NLYLKAIEEALRYSPPVMRTV-RKTKERVKLGDQTIEEGEYVRVWIASANRDEE 290 Query: 402 EFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 461 F D EKF P+ N + F +G +C G LAR+E + + + F Sbjct: 291 VFHDGEKFIPDRNPNPHLS---------FGSGIHLCLGAPLARLEARIAIEEFSKRFRHI 341 Query: 462 PLVDPKDID 470 ++D + + Sbjct: 342 EILDTEKVP 350 >3RWL-A nrPDB Length = 426 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 71/354 (20%), Positives = 118/354 (33%), Gaps = 63/354 (17%) Query: 120 PTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNV 179 P + R+ + + E I+ L+ L G+ FD + Sbjct: 117 PRHDEQRKAVSPIVAPANLA--ALEGTIRERVSKTLDGL--PVGEEFDWVDRVSIEITTQ 172 Query: 180 IADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRK--VIK 237 + LF + F E L T W + P RK +++ Sbjct: 173 MLATLF--------------DFPFEERRKL--TRWSDVTTAAPGGGVVESWDQRKTELLE 216 Query: 238 NVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLF 297 A + +ERV + D + L+ + A R T + V L Sbjct: 217 CAAYFQVLWNERVNK-----------DPGNDLISML--AHSPATRNMTPEEYLGNVLLLI 263 Query: 298 FAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEI 357 G +TT ++ G+L L K P+ KL ++ +V EI Sbjct: 264 VGGNDTTRNSMTGGVLALHKNPDQFAKLKA------------------NPALVETMVPEI 305 Query: 358 QRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNE 417 R+ T + +++ A D+ G I KG VV S D++ PE+F + Sbjct: 306 IRWQTPL-AHMRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDRP--- 361 Query: 418 NGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF-NLKPLVDPKDID 470 F G C G LA M+L +L IL F ++ + +P+ + Sbjct: 362 -----RPRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFSRIEVMAEPERVR 410 >5Z9I-A nrPDB Length = 398 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 67/408 (16%), Positives = 127/408 (31%), Gaps = 56/408 (13%) Query: 80 MHGYKAVKEALLDYKDEFSGRGDLPAFH---AHRDRGIIFNNGPTWKDIRRFSLTTLRNY 136 ++GY L + K S L A + + P + +R Sbjct: 38 VYGYPESAAILSNPKVFSSDTMRLDPIKLDEAIVEGDFAHTDPPKHRRLRGLVDHAFTPS 97 Query: 137 GMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKF 196 + K ESR+ H LL+ + Q P +I+D+L D Sbjct: 98 LVAKM--ESRVHGIIHELLDGVEGKS-QFDLVAEFAAPLPLIMISDLLGVPESDR----- 149 Query: 197 LRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQS 256 LF + + + P + K ++ + E+++Y ER E + Sbjct: 150 ----ALFRQWMDKMLDGSEK--FESPETVLEQEEELHKELELLWEMRDYWHERAAESRKR 203 Query: 257 LDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILM 316 PR+ LV E + + I+ L G TT+ + +L L Sbjct: 204 -----PREDLISQLVHAEVD----GQKLNDSQISNIANRLLVNGHLTTAMLIANTMLCLD 254 Query: 317 KYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDT 376 + + + ++ + + A++ E R+++ + + + Sbjct: 255 AFSDQDARVRADRS------------------LVPALLEESMRYMSPI-CGVGRATNSEV 295 Query: 377 IFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRV 436 G +IPK +++ + D ++F P+ F N + F G Sbjct: 296 EVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGRSPNAH---------LGFGRGIHF 346 Query: 437 CAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIH--IGFGCIP 482 C G LARME + +L + G +P Sbjct: 347 CLGRQLARMESKAAVEILLDRLPTLRADPANPPTFLQVVDASGVATLP 394 >5L1U-A nrPDB Length = 401 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 83/441 (18%), Positives = 133/441 (30%), Gaps = 84/441 (19%) Query: 62 QRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSG-RGDLPAFHAHRDRGIIFNNGP 120 Q+ GP+ + + ++ Y V+ L D + S A A R + G Sbjct: 28 QKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKSAARAFMVALAAGD 87 Query: 121 -------TWKDIRRFSLTTL--RNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDP-TF 170 +R + R + K E + L P D Sbjct: 88 DHETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDELLDQL-----AASAPPVDLHRV 142 Query: 171 LIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPG 230 L P V+ D+L D E F + +N + Sbjct: 143 LSFRLPTMVVCDLLGVPLAD-------------RERFGQWARGTFDQSDN-----EHSAN 184 Query: 231 SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGIT 290 + ++V+ +Y+ E V + D +L E+ EK A + + Sbjct: 185 TFQQVV-------DYMLELVARKRV--------EPGDDILSELIAEKDGALSDADIAHLG 229 Query: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350 V G ETT + G L+L++ P +L E+ Sbjct: 230 NAVLLF---GYETTIVRIDLGTLLLLRNPVQRAQLAED------------------PGLA 268 Query: 351 DAVVHEIQRFI---TLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE 407 A V EI R + +P A D +I G V+ + + YD++ FPD Sbjct: 269 PAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGG 328 Query: 408 KFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK 467 F F G R C G LAR+EL + + + L P+ Sbjct: 329 LFDLTRV--------RPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPE 380 Query: 468 D---IDLSPIHIGFGCIPPRY 485 + I GF IP + Sbjct: 381 ESLRWQEHRITGGFDEIPVTF 401 >1Q5D-A nrPDB Length = 419 Score = 147 bits (372), Expect = 7e-36, Method: Composition-based stats. Identities = 71/357 (19%), Positives = 120/357 (33%), Gaps = 53/357 (14%) Query: 103 LPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQ 162 +P + G+ +R+ + + + E IQR LL+A R Q Sbjct: 84 IPELSDMKKYGLFGLPPEDHARVRKLVNPSFTSRAIDLLRAE--IQRTVDQLLDA-RSGQ 140 Query: 163 GQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFP 222 + P I+ +L DEKF R + P Sbjct: 141 EEFDVVRDYAEGIPMRAISALLKVPA--ECDEKFRRFGSATARALGVGLVP--------- 189 Query: 223 SFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAER 282 +V + + V+E + H LD L + +L + + + R Sbjct: 190 -----------RVDEETKTLVASVTEGLALLHGVLDERRRNPLENDVLTMLLQAEADGSR 238 Query: 283 LYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIK 342 L T + + V + AGT+TT + + +L L++ PE E + E Sbjct: 239 LSTKE-LVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAE-------------- 283 Query: 343 DRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQE 402 M + E+ RF ++ A +D + G I KG +V + S L D Sbjct: 284 ----PGLMRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIPSALRDGTV 339 Query: 403 FPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFN 459 F P+ F + + + G VC G LAR+E + + I + F Sbjct: 340 FSRPDVFDVRRDTSASLAY---------GRGPHVCPGVSLARLEAEIAVGTIFRRFP 387 >5FYF-A nrPDB Length = 470 Score = 147 bits (371), Expect = 9e-36, Method: Composition-based stats. Identities = 71/419 (16%), Positives = 140/419 (33%), Gaps = 65/419 (15%) Query: 64 FGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDL----PAFHAHRDRGIIFNNG 119 FGP ++ + ++ + + D FS + P + I + Sbjct: 102 FGPFWS----------VTRFEDIL-FVDKSHDLFSAEPQIILGDPPEGLSVEMFIAM-DP 149 Query: 120 PTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNV 179 P R + + + E I+ +L++L P D F A Sbjct: 150 PKHDVQRSSVQGVVAPKNLKEM--EGLIRSRTGDVLDSL------PTDKPFNWVPAVSKE 201 Query: 180 IADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNV 239 + + D+ E+ +L+ +++ ++ + + + R + Sbjct: 202 LTGRMLATLLDFPYEERHKLVE-WSDRMAGAASATGGEFADENAMFDDAADMARSFSRLW 260 Query: 240 AEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFA 299 + KE ++ DL L E + + + L Sbjct: 261 RD---------KEARRAAGEEPGFDLISLLQSNKETKDLINRPM----EFIGNLTLLIVG 307 Query: 300 GTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQR 359 G +TT ++ GL+ + ++P EKL + + +V EI R Sbjct: 308 GNDTTRNSMSGGLVAMNEFPREFEKLKA------------------KPELIPNMVSEIIR 349 Query: 360 FITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENG 419 + T + + + A +D G I KG VV S D ++F +P++F + Sbjct: 350 WQTPL-AYMRRIAKQDVELGGQTIKKGDRVVMWYASGNRDERKFDNPDQFIIDR------ 402 Query: 420 KFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGF 478 K + F G C G LA ++L +L IL+ F+ +V+ + S G+ Sbjct: 403 --KDARNHMSFGYGVHRCMGNRLAELQLRILWEEILKRFDNIEVVEEPERVQSNFVRGY 459 >1UE8-A nrPDB Length = 367 Score = 144 bits (363), Expect = 8e-35, Method: Composition-based stats. Identities = 70/429 (16%), Positives = 129/429 (30%), Gaps = 90/429 (20%) Query: 53 IPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSG-----------RG 101 + F ++ + PV+ Y G ++ + Y+ K L D+K S R Sbjct: 1 MYDWFKQMRKE-SPVY--YDG--KVWNLFKYEDCKMVLNDHKRFSSNLTGYNDKLEMLRS 55 Query: 102 DLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKT 161 F ++ ++ P ++R + + ++ LL L + Sbjct: 56 GKVFFDIPTRYTMLTSDPPLHDELRNLTADAFNPSNLPVDF----VREVTVKLLSELDEE 111 Query: 162 QGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNF 221 FD ++ + + D W L Sbjct: 112 ----FDVIESFAIPLPILVISKMLGINPDVKK-----------------VKDWSDLVALR 150 Query: 222 PSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAE 281 + RK + E+ + + + + + + L E+EKE + Sbjct: 151 LGRADEIFSIGRKYL----ELISFSKKELDSRKGKEIVDLTGKIANSNLSELEKEGY--- 203 Query: 282 RLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAI 341 L AG ETT+ + + Y + + E+ Sbjct: 204 -----------FILLMIAGNETTTNLIGNAIEDFTLY-NSWDYVREKG------------ 239 Query: 342 KDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQ 401 V E RF V + R +I +G +V + S D + Sbjct: 240 --------ALKAVEEALRFSPPVMRTI-RVTKEKVKIRDQVIDEGELVRVWIASANRDEE 290 Query: 402 EFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 461 F DP+ F P+ N + F +G +C G LAR+E + L + F +K Sbjct: 291 VFKDPDSFIPDRTPNPHLS---------FGSGIHLCLGAPLARLEARIALEEFAKKFRVK 341 Query: 462 PLVDPKDID 470 +V + ID Sbjct: 342 EIVKKEKID 350 >6HQG-A nrPDB Length = 425 Score = 144 bits (363), Expect = 8e-35, Method: Composition-based stats. Identities = 74/421 (17%), Positives = 126/421 (29%), Gaps = 71/421 (16%) Query: 63 RFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTW 122 ++ + + + V + L D D+F LP F A + P Sbjct: 68 KYNDIMAVDTNHE---VFSSEPTI--VLPDPADDF----TLPMFIAM--------DPPKH 110 Query: 123 KDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIAD 182 R+ + + E I+ A +L+ L G+ + + + Sbjct: 111 DVQRKTVQPIVAPNHLA--YLEPIIRERAGKILDDL--PIGEEINWVDKVSIELTTMTLA 166 Query: 183 ILFR-KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAE 241 LF D F + +L T + + N + + + V Sbjct: 167 TLFDFPWEDRRKLTFWSDVATSAPESGILGTTDPEEHENL---------RRQTLFECVDY 217 Query: 242 VKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGT 301 +ERV P+ +L E K+ + L G Sbjct: 218 FMRLWNERV--------NAPPKPDLISMLAHGESTKN-----MDRMEYLGNLILLIVGGN 264 Query: 302 ETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFI 361 +TT T+ +L L + P+ + KL E + A+V E R+ Sbjct: 265 DTTRNTISGSVLALHQNPDQDRKLRE------------------NPGLIPAMVSETIRWQ 306 Query: 362 TLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKF 421 T + + + A RD G I +G V S D + P + E Sbjct: 307 TPL-AYMRRRAKRDFELGGKTIREGDKVAMWYVSGNRDEEVIDRPNDYWIERP------- 358 Query: 422 KYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCI 481 F G C G LA ++L ++ IL F +V P S G+ + Sbjct: 359 -RVRQHLSFGFGVHRCVGNRLAELQLKIIWEEILARFPRLEVVGPPRRVYSSFVKGYEEL 417 Query: 482 P 482 P Sbjct: 418 P 418 >4PWV-A nrPDB Length = 446 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 75/415 (18%), Positives = 131/415 (31%), Gaps = 70/415 (16%) Query: 79 VMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRG-----IIFNNGPTWKDIRRFSLTTL 133 V+ Y V D K S +G++ + +G + +R L + Sbjct: 78 VVSRYADVMALYKDNKKLTSEKGNVLVTLLAGGDSAAGKMLAVTDGAMHRGLRNVLLKSF 137 Query: 134 RNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYND 193 + ++ R+ +++A R+ G+ + P N I+D+L D Sbjct: 138 SPQALKPIVDQIRVNT-TRLVVDAARR--GECDFAADVAEQIPLNTISDLLGVPA---AD 191 Query: 194 EKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEH 253 +FL + + + E+ Y SE V E Sbjct: 192 REFLLKLNKSALSSEDADQSATDAWL------------------ARNEILLYFSELVAER 233 Query: 254 HQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLL 313 D+ L M + T + I + L G ET+ ++ + Sbjct: 234 RA----KPTEDVISVLANSMV-----DGKPLTEEVIVLNCYSLILGGDETSRLSMIDSVQ 284 Query: 314 ILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEAT 373 +YP+ E L + +++ E+ R+ T + A Sbjct: 285 TFTQYPDQWELLRDGKVT------------------LESATEEVLRWATPA-MHFGRRAV 325 Query: 374 RDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTG 433 D G +I G VV +S D + F DP F N++ F G Sbjct: 326 TDMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDLNRSPNKHIT---------FGYG 376 Query: 434 KRVCAGEGLARMELFLLLCAILQHFN--LKPLVDPKDIDLSPIHIGFGCIPPRYK 486 C G L R E+ LL A L+ + + +P+ I S G +P R + Sbjct: 377 PHFCLGAYLGRAEVHALLDA-LRTYTTGFEITGEPQRIH-SNFLTGLSRLPVRIQ 429 >5HIW-A nrPDB Length = 398 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 78/445 (17%), Positives = 139/445 (31%), Gaps = 77/445 (17%) Query: 53 IPKSFTRLAQRFGPVFTLYV-------------GSQRMVVMHGYKAVKEALLDYKDEFSG 99 K+ + F +++ G VV+ G V A+L + FS Sbjct: 3 PRKNLFSFTSKDPSAFGIHLAAAAREHSVYFDEGLGVPVVLRGADVV--AVLRDSETFST 60 Query: 100 RGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEAL- 158 R ++ G +RR + + + + E+ + A ++E L Sbjct: 61 RTY---DTGIMKGALVTLGGEAHTRMRRLF-NAVLSPRVISRYEEATVTPVARRVVERLV 116 Query: 159 RKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLY 218 RK + + FD P V + + F +E+ L + + P + Sbjct: 117 RKERAELFD--DFAISMPMGVTSAL-----FGLPEERIAENDALIRKMIRSVVMPQDPVV 169 Query: 219 NNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKH 278 R + ++ER H +D LL E+ + Sbjct: 170 V----------AEGRSAHAAMEAQLREIAEREVAH-----------PSDTLLGEIARA-I 207 Query: 279 SAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRI 338 AE L ++ V L ETTS L L+ L+ +P+ +L + Sbjct: 208 VAEGLGGVEACEGVVLTLILGSYETTSWMLANLLVALLAHPDAMNQLRQ----------- 256 Query: 339 PAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLY 398 + + + E R+ + + + R+ G + GT++ +L + Y Sbjct: 257 -------QPSLLPQAIEESTRWCSSA-AGIVRFVEREATIGGETLAAGTILYLSLIARHY 308 Query: 399 DNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 D + +P PE F F G C G LARME + + +L+ F Sbjct: 309 DEEIYPRPETFDIHRRPVG---------MLNFGGGLHYCVGAPLARMEARVGVSLLLERF 359 Query: 459 NLKPLVDPKDIDLSPIHIGFGCIPP 483 S G P Sbjct: 360 PALRADPTVQPTFSTAPRGAAAFGP 384 >6HQW-A nrPDB Length = 445 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 58/371 (15%), Positives = 122/371 (32%), Gaps = 39/371 (10%) Query: 108 AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFD 167 + + GI + P D ++ + L + + + + A T + + Sbjct: 101 SWQYGGITIGDPPEDVDPQKLAERQLPMFIAMDRPDHT-----GQRRTVAPAFTPAKMVE 155 Query: 168 PTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHY 227 I +V+ + + + FD+ D+ + L L PW + + Sbjct: 156 MEAEIRRRTASVLDSLPWGERFDWVDKVSIELTTGM--LAILFGFPWAD-RRLLTFWSDW 212 Query: 228 LPGSHRKVIKNVAEVK-EYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTM 286 + + +A+ + ++ E + + L+ M A + Sbjct: 213 AGDVELTLARELADTRFGFLGEMAHYFQRLWGARMQAPPSGDLISMM--IHSEAMNHMSP 270 Query: 287 DGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQE 346 + L G +TT T+ + L K+P+ E L + Sbjct: 271 QEFMGNLVLLIVGGNDTTRNTMSGIVHALDKFPDQRELLERDAS---------------- 314 Query: 347 MPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDP 406 + V E R++T + +++ AT DT G I G V+ S D F +P Sbjct: 315 --LIPNAVQECIRYVTPL-AHMRRTATADTELFGNQIKAGEKVILWYISANRDETVFENP 371 Query: 407 EKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAIL-QHFNLKPLVD 465 +K + + F G C G LA ++L +LL + + ++ + Sbjct: 372 DKLMVDRP--------NARRHLSFGHGIHRCVGARLAELQLRILLEEMHERRMRVRVAGE 423 Query: 466 PKDIDLSPIHI 476 + + + +H Sbjct: 424 VERVRANFVHG 434 >2UUQ-A nrPDB Length = 414 Score = 142 bits (357), Expect = 5e-34, Method: Composition-based stats. Identities = 66/398 (16%), Positives = 114/398 (28%), Gaps = 66/398 (16%) Query: 79 VMHGYKAVKEALLDYKDEFS------GRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTT 132 V+ + V A D++ S G+L H ++ + P + R+ Sbjct: 55 VLSRHADVWSAARDHQTFSSAQGLTVNYGELEMIGLHDTPPMVMQDPPVHTEFRKLVSRG 114 Query: 133 LRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYN 192 + E +++ LE LR G T L P V+A L D+ Sbjct: 115 FT--PRQVETVEPTVRKFVVERLEKLRANGGGDI-VTELFKPLPSMVVAHYLGVPEEDW- 170 Query: 193 DEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKE 252 W Q + G+ + V + Y + ++ Sbjct: 171 ----------------TQFDGWTQAIVAANAV----DGATTGALDAVGSMMAYFTGLIER 210 Query: 253 HHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGL 312 D L+ + I + G +T + L + Sbjct: 211 RRT----EPADDAISHLVAAGVGADGDTAGTLS---ILAFTFTMVTGGNDTVTGMLGGSM 263 Query: 313 LILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEA 372 +L + P+ L ++ P IP V E+ R + V L Sbjct: 264 PLLHRRPDQRRLLLDD------PEGIPD------------AVEELLRLTSPVQ-GLARTT 304 Query: 373 TRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF-PDPEKFKPEHFLNENGKFKYSDYFKPFS 431 TRD IP G V+ S D +++ PD + FS Sbjct: 305 TRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTRCP---------RNILTFS 355 Query: 432 TGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDI 469 G C G ARM+ + L +L + + + + Sbjct: 356 HGAHHCLGAAAARMQCRVALTELLARCPDFEVAESRIV 393 >2FR7-A nrPDB Length = 412 Score = 141 bits (355), Expect = 7e-34, Method: Composition-based stats. Identities = 73/423 (17%), Positives = 120/423 (28%), Gaps = 68/423 (16%) Query: 65 GPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRG----DLPAFHAHRDRGIIF-NNG 119 GPV +Y+ + + Y V L D S RG D R +I + Sbjct: 47 GPV--VYLDKWNVYGVARYAEVYAVLNDPLTFCSSRGVGLSDFKKEKPWRPPSLILEADP 104 Query: 120 PTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNV 179 P R L M + A ++ L G L P +V Sbjct: 105 PAHTRTRAVLSKVLSPATMKRLR--DGFAAAADAKIDELLARGGNIDAIADLAEAYPLSV 162 Query: 180 IADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNV 239 D + K N P Sbjct: 163 FPDAMGLKQEGRE--------------------------NLLPYAGLVF-----NAFGPP 191 Query: 240 AEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFA 299 E+++ ER H + C R S T + + V L A Sbjct: 192 NELRQSAIERSAPHQAYVAEQCQRPNLAPGGFGACIHAFSDTGEITPEEAPLLVRSLLSA 251 Query: 300 GTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQR 359 G +TT + + L ++P+ +L + E R Sbjct: 252 GLDTTVNGIAAAVYCLARFPDEFARLRAD------------------PSLARNAFEEAVR 293 Query: 360 FITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENG 419 F + V TRD G I +G V+ L S D + + DP+++ + + Sbjct: 294 FESPVQ-TFFRTTTRDVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRYDITRKTSGH- 351 Query: 420 KFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFG 479 F +G +C G+ +AR+E ++L A+ + + P + G Sbjct: 352 --------VGFGSGVHMCVGQLVARLEGEVVLAALARKVAAIEIAGPLKRRFNNTLRGLE 403 Query: 480 CIP 482 +P Sbjct: 404 SLP 406 >2NZA-A nrPDB Length = 413 Score = 141 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 71/471 (15%), Positives = 134/471 (28%), Gaps = 80/471 (16%) Query: 26 VHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYV--GSQRMVVMHGY 83 + PP P L+ L + GP+ + + G + Y Sbjct: 6 TTLTGQSPPPVRDWP----ALDLDGPEFDPVLAELMRE-GPLTRVRLPHGEGWAWLATRY 60 Query: 84 KAVKEALLDYK---DEFSGR--GDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGM 138 VK D + E + R L R + F + P +RR Sbjct: 61 DDVKAITNDPRFGRAEVTQRQITRLAPHFKPRPGSLAFADQPDHNRLRRAVAGAFTVG-- 118 Query: 139 GKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLR 198 + R Q L++ + ++ P V+++++ D Sbjct: 119 ATKRLRPRAQEILDGLVDGILAEGPPADLVERVLEPFPIAVVSEVMGVPAADRE------ 172 Query: 199 LMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLD 258 + + ++ST G + + +++E V+ S Sbjct: 173 --RVHSWTRQIISTS----------------GGAEAAERAKRGLYGWITETVRARAGS-- 212 Query: 259 PNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKY 318 D+ L + + + L G E + + L +L+ Sbjct: 213 --EGGDVYSMLGAAVGRGEVGET------EAVGLAGPLQIGG-EAVTHNVGQMLYLLLTR 263 Query: 319 PEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITL-VPSNLPHEATRDTI 377 E+ ++ E + E+ R+I+ L A D Sbjct: 264 RELMARMRE------------------RPGARGTALDELLRWISHRTSVGLARIALEDVE 305 Query: 378 FRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVC 437 G I G V + + D FPDP++ + N + + G C Sbjct: 306 VHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDRDPNPHLAY---------GNGHHFC 356 Query: 438 AGEGLARMELFLLLCAILQHFNLKPLVDPKD---IDLSPIHIGFGCIPPRY 485 G LARM+ LL+ +L+ L P + + G +P + Sbjct: 357 TGAVLARMQTELLVDTLLERLPGLRLAVPAEQVAWRRKTMIRGPRTLPCTW 407 >6DCD-A nrPDB Length = 424 Score = 140 bits (352), Expect = 2e-33, Method: Composition-based stats. Identities = 82/437 (18%), Positives = 136/437 (31%), Gaps = 98/437 (22%) Query: 51 KNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFS-----GRGDLPA 105 + F L + PV L + +V + GY+ A+ D FS G P Sbjct: 17 PDPHPYFDYLRSQ-SPV--LRLPQYGVVAVTGYEEA-TAVYKDTDSFSNCVALGGPFPPL 72 Query: 106 FHAHRDRGI-----------------IFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQ 148 A + + + P R L + + NE + Sbjct: 73 PFAPNGDDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRLLTPSRLKQ--NEEFMW 130 Query: 149 REAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYND-------EKFLRLMY 201 R A L+ G+ + VIAD+L D D ++ R+ Sbjct: 131 RLADRQLDEFLGA-GECEFISEYAKPFATLVIADLLGVPEDDRKDFRVVLGADRMGRVGA 189 Query: 202 LFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNC 261 L +E+ + WL + Y+ +R ++ Sbjct: 190 LDHESVGVNPLQWLD-----------------------DKFSAYIEDRRRQPR------- 219 Query: 262 PRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEI 321 D+ L + + E + + + LF AG ETT+ L + +L P+I Sbjct: 220 -NDVLTALATATYPDGSTPEVI----DVVRSATFLFAAGQETTAKLLTAAMRVLGDRPDI 274 Query: 322 EEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGY 381 + +L E + + E R + V S+ A + T G Sbjct: 275 QRRLRE------------------NRSLIPNFIEESLRMDSPVKSD-SRLARKRTTVGGL 315 Query: 382 LIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEG 441 I GTVV+ + D + F DP +F+ + F+ G C G Sbjct: 316 DIAAGTVVMVLPGAANRDPRRFEDPHEFRLDRP--------NVREHMAFARGVHSCPGGP 367 Query: 442 LARMELFLLLCAILQHF 458 LAR+E + L IL Sbjct: 368 LARVEGRVSLERILDRM 384 >6BLD-A nrPDB Length = 419 Score = 139 bits (351), Expect = 2e-33, Method: Composition-based stats. Identities = 65/375 (17%), Positives = 110/375 (29%), Gaps = 53/375 (14%) Query: 102 DLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKT 161 ++PA + + + P +R+ + E I+ A +++ LR Sbjct: 90 NVPAELLEASQSFLAMDPPRHTKLRKLVSAAFT--PRQVRRIEDSIKINAKGIVDELRMA 147 Query: 162 QGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNF 221 G P ++D++ D ++ L + Sbjct: 148 GGGVDFVEHCAKELPIRTLSDMVGIPEADR----------------ERVAHAADALVSWA 191 Query: 222 PSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAE 281 + +N + + + E D L + + + Sbjct: 192 DPRYLNGREPLAVLFENQMYLHQVAASLAAERRDR--------PGDDLFSALVNAEVDGD 243 Query: 282 RLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAI 341 RL D + L AG +TT T+ +GL L +P + L + D IG Sbjct: 244 RLADAD-VAAFFVLLAVAGNDTTRQTISHGLKALTDFPSQKAWLLADFDTRIG------- 295 Query: 342 KDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQ 401 V E+ R+ T V A D G LI G VV S +D Sbjct: 296 ----------TAVEELVRWATPV-MTFRRTAAADFELGGQLIRAGEKVVMFYASGNWDED 344 Query: 402 EFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 461 F PE+ N + F C G LAR +L + +L Sbjct: 345 AFCHPERLDLSRSPNPHVGFGGGGVHF--------CLGAHLARAQLRAIFGELLVQLPDI 396 Query: 462 PLVDPKDIDLSPIHI 476 DP + + +H Sbjct: 397 QAGDPVYVPGNFVHA 411 >5HDI-A nrPDB Length = 404 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 65/405 (16%), Positives = 119/405 (29%), Gaps = 73/405 (18%) Query: 79 VMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRD-------------RGIIFNNGPTWKDI 125 + G+ AV EA+ +D S + A + + P Sbjct: 42 AVCGWDAVNEAIGRPEDFSSNLTATMTYTAEGTAKPFEMDPLGGPTHVLATADDPAHAVH 101 Query: 126 RRFSLTTLRNYGMGKQGNESRIQREAHFL-LEALRKTQGQPFDPTFLIGCAPCNVIADIL 184 R+ L L + E + A L ++ ++ D A N + ++ Sbjct: 102 RKLVLRHLAA--KRIRVMEQFTVQAADRLWVDGMQ-------DGCIEWMGAMANRLPMMV 152 Query: 185 FRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKE 244 + D +L+ QL + E+ Sbjct: 153 VAELIGLPDPDIAQLVK--------WGYAATQLLEGLVE-----NDQLVAAGVALMELSG 199 Query: 245 YVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETT 304 Y+ E+ D D LL E+ S E + + LF AG E+T Sbjct: 200 YIFEQF--------DRAAADPRDNLLGELATACASGELDTLTAQVMM--VTLFAAGGEST 249 Query: 305 STTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLV 364 + L + IL P+I++++ + A + E R+ Sbjct: 250 AALLGSAVWILATRPDIQQQVRA------------------NPELLGAFIEETLRYEPPF 291 Query: 365 PSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYS 424 + H T G +P + ++ + D +F P +F+ + Sbjct: 292 RGHYRHVRNA-TTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDR--------AGG 342 Query: 425 DYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDI 469 F G C G LAR+E ++L +L ++ D Sbjct: 343 KGHISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVGGW 387 >5H1Z-A nrPDB Length = 407 Score = 136 bits (342), Expect = 3e-32, Method: Composition-based stats. Identities = 61/351 (17%), Positives = 112/351 (31%), Gaps = 59/351 (16%) Query: 120 PTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNV 179 P RR M + + I+ +L++L PFD + Sbjct: 97 PKHTGQRRTVAPAFTPSEMVRMSDN--IRMRTAEVLDSLEWN--TPFDWVDTVSVELTTQ 152 Query: 180 IADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNV 239 + ILF F + + + L + + L+ L+L + ++++ Sbjct: 153 MLAILF--DFPWEERRKLTFWSDWAGDIELVKNEELRL----------------ERLRHM 194 Query: 240 AEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFA 299 E Y + + T L+ M A + L Sbjct: 195 YECGGYFQNL-------WNAKIGKPPTPDLISMM--IHSDAMAEMDQMEFLGNLILLIVG 245 Query: 300 GTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQR 359 G +TT T+ L +P+ KL + PS IP V EI R Sbjct: 246 GNDTTRNTMSAVAYGLDLFPDQRAKLEAD------PSMIP------------NTVQEIIR 287 Query: 360 FITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENG 419 + T + +++ AT D+ G I G + S D F + ++ + Sbjct: 288 WQTPL-AHMRRTATVDSELEGQQIKAGDKLALWYISANRDESVFENADRIIVDRP----- 341 Query: 420 KFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAIL-QHFNLKPLVDPKDI 469 + F G C G LA +++ +LL + + + L +P+ + Sbjct: 342 ---NARRHLAFGHGIHRCVGARLAELQIAVLLEEMAKRRMRVNVLGEPERV 389 >3OO3-A nrPDB Length = 384 Score = 136 bits (341), Expect = 3e-32, Method: Composition-based stats. Identities = 68/434 (15%), Positives = 134/434 (30%), Gaps = 81/434 (18%) Query: 62 QRFGPVFTLY----VGSQRMVVMHGYKAVKEALLDYKDEFSGRG-DLPAFHAHRDRGIIF 116 Q+ GP+ + ++ ++ G+ V+ L D++ S R D A A + Sbjct: 22 QKAGPLHEYDTEPGMDGRKQWLVTGHDEVRAILADHERFSSMRPVDDEADRALLPGILQA 81 Query: 117 NNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIG-CA 175 + P +RR M + RI+ L+ ++ G P D Sbjct: 82 YDPPDHTRLRRTVAPAYSARRM--ERLRPRIEEIVEECLDDF-ESVGAPVDFVRHAAWPI 138 Query: 176 PCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKV 235 P + + L D + R++ E+ Sbjct: 139 PAYIACEFLGVPRDD--QAELSRMIRESRES----------------------------R 168 Query: 236 IKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVAD 295 + + + + + L RD D ++ + +E + + + + Sbjct: 169 LPRQRTLSGL---GIVNYTKRLTSGKRRDPGDGMIGVIVREH--GAEISDEELAGLAEGN 223 Query: 296 LFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 L A E + L +L+L+ +P+ L E + +D+ Sbjct: 224 LIMAA-EQMAAQLAVAVLLLVTHPDQMALLRE------------------KPELIDSATE 264 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E+ R ++V + P A D G I G V+ ++ + ++F Sbjct: 265 EVLRHASIVEAPAPRVALADVRMAGRDIHAGDVLTCSMLATNRAP-----GDRFDITR-- 317 Query: 416 NENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKD----IDL 471 F G C G LAR++L + L A++ F L P++ Sbjct: 318 -------EKATHMAFGHGIHHCIGAPLARLQLRVALPAVVGRFPSLRLAVPEEDLRFKPG 370 Query: 472 SPIHIGFGCIPPRY 485 P +P + Sbjct: 371 RPAPFAVEELPLEW 384 >4DO1-A nrPDB Length = 410 Score = 135 bits (340), Expect = 4e-32, Method: Composition-based stats. Identities = 82/455 (18%), Positives = 142/455 (31%), Gaps = 68/455 (14%) Query: 33 PPGPFPLPIIG-NLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALL 91 PP +P + + F L+ + P + + GPV +Y+ + + Y V L Sbjct: 13 PPNDSTIPHLAIDPFSLDFFDDPYPDQQTLRDAGPV--VYLDKWNVYGVARYAEVHAVLN 70 Query: 92 DYKDEFSGRG----DLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRI 147 D S RG D R +I P R L+ + + K + Sbjct: 71 DPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATMKTIRDGF- 129 Query: 148 QREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENF 207 A ++ L +G L P +V D M L E Sbjct: 130 AAAADAKVDELL-QRGCIDAIADLAEAYPLSVFPD----------------AMGLKQEGR 172 Query: 208 HLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTD 267 L ++N F E+++ ER H ++ C R Sbjct: 173 EHLLPYAGLVFNAFGP---------------PNELRQTAIERSAPHQAYVNEQCQRPNLA 217 Query: 268 CLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHE 327 + T D + V L AG +TT + + L ++P ++L Sbjct: 218 PGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRL-- 275 Query: 328 EIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGT 387 R + E RF + V TR+ G +I +G Sbjct: 276 ----------------RSDPTLARNAFEEAVRFESPVQ-TFFRTTTREVELGGAVIGEGE 318 Query: 388 VVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMEL 447 V+ L S D + + DP+ + + + F +G +C G+ +AR+E Sbjct: 319 KVLMFLGSANRDPRRWSDPDLYDITRKTSGH---------VGFGSGVHMCVGQLVARLEG 369 Query: 448 FLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIP 482 ++L A+ + + P + G +P Sbjct: 370 EVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLP 404 >3OFT-A nrPDB Length = 396 Score = 134 bits (338), Expect = 6e-32, Method: Composition-based stats. Identities = 77/411 (18%), Positives = 127/411 (30%), Gaps = 76/411 (18%) Query: 84 KAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFN------NGPTWKDIRRFSLTTLRNYG 137 V+E D + R G + +G K R + L + Sbjct: 55 DVVRELWGD-----AERLSSQCLAVTPGLGKVMQFIPLQQDGAEHKAFRTPVMKGLASRF 109 Query: 138 MGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFL 197 + E ++Q A L+E+LR +G + P N+ FL Sbjct: 110 VV--ALEPKVQAVARKLMESLR-PRGSCDFVSDFAEILPLNI----------------FL 150 Query: 198 RLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSL 257 L+ + E+ L +QL P V + +Y+ +++ Sbjct: 151 TLIDVPLEDRPRLRQLGVQLTR---------PDGSMTVEQLKQAADDYLWPFIEKRMA-- 199 Query: 258 DPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMK 317 DL +L E R +T+D +L F G +T + + L L + Sbjct: 200 --QPGDDLFSRILSE-----PVGGRPWTVDEARRMCRNLLFGGLDTVAAMIGMVALHLAR 252 Query: 318 YPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTI 377 +PE + L E + A E+ R V + A D Sbjct: 253 HPEDQRLLRE------------------RPDLIPAAADELMRRYPTV--AVSRNAVADVD 292 Query: 378 FRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVC 437 G I KG +V D F PE+ + + L G C Sbjct: 293 ADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGLAP-------IRHTTMGVGAHRC 345 Query: 438 AGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGF-GCIPPRYKL 487 G GLARME+ + L L L K + + ++G +P ++ Sbjct: 346 VGAGLARMEVIVFLREWLGGMPEFALAPDKAVTMKGGNVGACTALPLVWRA 396 >2X9P-A nrPDB Length = 404 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 69/422 (16%), Positives = 125/422 (29%), Gaps = 76/422 (18%) Query: 57 FTRLAQRFGPVFTLYV-GSQRMVVMHGYKAVKEALLDY--KDEFSGRGDLPAFHA--HRD 111 R Q GP+ + ++ + +K+ L D + D Sbjct: 31 LLRALQDRGPIHRVRTPAGDEAWLVTRHAELKQLLHDERIGRTHPDPPSAAQYVRSPFLD 90 Query: 112 RGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNE--SRIQREAHFLLEALRKTQGQPFDPT 169 I + + + + L ++ E +++ A LL+A QG P D Sbjct: 91 LLISDADAESGRRQHAETRRLLTPLFSARRVLEMQPKVEEAADTLLDAFI-AQGPPGDLH 149 Query: 170 FLIGCA-PCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYL 228 + V+ +++ ++ L L L Sbjct: 150 GELTVPFALTVLCEVIGVP-----PQRRAELTTLLAGIAKL------------------- 185 Query: 229 PGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDG 288 ++ ++ YV+ V+ P+ L D T D Sbjct: 186 -DDREGAVRAQDDLFGYVAGLVEHKRAEPGPDIISRLNDG--------------ELTEDR 230 Query: 289 ITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMP 348 + L FAG ++ ++ + G+++L +P+ + Sbjct: 231 VAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAA------------------ALADPD 272 Query: 349 YMDAVVHEIQRFITLVPSNLP-HEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE 407 M V E+ R S LP A+ D F G I G +V+ L +D + F PE Sbjct: 273 VMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAFTGPE 332 Query: 408 KFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK 467 +F N + F G C G LAR+EL + + P Sbjct: 333 EFDAARTPNPHLT---------FGHGIWHCIGAPLARLELRTMFTKLFTRLPELRPELPV 383 Query: 468 DI 469 + Sbjct: 384 EQ 385 >5HH3-A nrPDB Length = 397 Score = 133 bits (335), Expect = 2e-31, Method: Composition-based stats. Identities = 80/407 (19%), Positives = 126/407 (30%), Gaps = 77/407 (18%) Query: 73 GSQRMVVMHGYKAVKEALLDYKDEFSGR---GDLPAFHAHRDRGIIFNNGPTWKDIRRFS 129 G + + GY +++ L D+FS R G A + + P +RR Sbjct: 50 GGRTAWLATGYDEIRQVL--SSDDFSARLLYGGTAAGITWPGF-LTQYDPPEHTRLRRMV 106 Query: 130 LTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAP-CNVIADILFRKH 188 M Q + +++R L+A+ G P D G + D L Sbjct: 107 APAFAVRRM--QKFQPQVERVVQDSLDAIEAL-GGPVDFVPRFGWSVATTATCDFLGIPR 163 Query: 189 FDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSE 248 D D L N F ++++ + R Sbjct: 164 DDQADL----ARSLHASRTERSGKRRTAAGNKFMTYMNKMTARTR--------------- 204 Query: 249 RVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTL 308 RD D + + +E T +T A + AG + + L Sbjct: 205 --------------RDPGDDMFGVVVREYGDE---ITDAELTGVAAFVMGAGADQVARFL 247 Query: 309 RYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNL 368 G ++ PE L E+ D V P D E+ R++T Sbjct: 248 AAGAWLMADDPEQFALLREKPDTV------PDWLD------------EVIRYLTTDEKTH 289 Query: 369 PHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE-KFKPEHFLNENGKFKYSDYF 427 P AT D +LI G V +L + + FP PE +F E+ Sbjct: 290 PRVATDDVRIGDHLIKAGDTVTCSLLAANR--RNFPRPEDRFDITRVRPEH--------- 338 Query: 428 KPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDP-KDIDLSP 473 F G C G LA + + A+ F L +P ++I L P Sbjct: 339 LAFGHGIHHCLGRSLAELVFRTAIPALAHRFPTLRLAEPHREIRLGP 385 >6GII-A nrPDB Length = 479 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 70/427 (16%), Positives = 134/427 (31%), Gaps = 70/427 (16%) Query: 54 PKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSG-------RGDLPAF 106 P F R A+ P+F Y V+ Y +K+ D + Sbjct: 80 PAQFVRWAREQVPIF--YAPKLNYWVVTRYDTIKQIFRDPVTFSPSNVLQSFAQPSAEVR 137 Query: 107 HAHRDRGIIFN------NGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRK 160 G FN + P + RR + + + + E ++ + Sbjct: 138 QVLERYGYAFNRTLVNEDEPMHLERRRVLMEPFASEHLAEH--EPMVRELVRRAVNRFID 195 Query: 161 TQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNN 220 T G+ +I P V + F D + EK R + + Sbjct: 196 T-GRADLVDQMIWEVPFTV--ALHFLGVDDDDREKMRRF----------------AIAHT 236 Query: 221 FPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSA 280 +F P V + V + ++ E +++ ++ D + +++ Sbjct: 237 VNAFGRPSPEEQLAVAETVGQFWQFCGEVLEKMRRTADGPGW-------MRYSIRQQKLY 289 Query: 281 ERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPA 340 + T + + + A ETT L L+++ + ++ + PS IP Sbjct: 290 PDVVTDSYLHSMMQAIIVAAHETTVFATTNALKTLLEHETVWREICAD------PSLIP- 342 Query: 341 IKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDN 400 A E R+ V + TR+ G +P G ++ + S +D+ Sbjct: 343 -----------AAAEECLRYNGPV-AGWRRRTTREVEVEGVRLPVGANILMVVASANHDS 390 Query: 401 QEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNL 460 F DPE F + F G C G L RME+ +++ + + Sbjct: 391 AHFDDPEFFDIGR--------SNASEHLNFGYGAHQCLGRNLGRMEMQIMIEELSRRLPH 442 Query: 461 KPLVDPK 467 L + + Sbjct: 443 MRLAEQR 449 >6HQD-A nrPDB Length = 420 Score = 130 bits (328), Expect = 9e-31, Method: Composition-based stats. Identities = 80/447 (17%), Positives = 145/447 (32%), Gaps = 70/447 (15%) Query: 49 ELKNIPKSFTRLAQR----------FGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFS 98 E + F RL + +GP +++ S +V + V + Sbjct: 30 ERDGLHPYFERLRREDPVHYCKASEYGPYWSITKFS-DIVAIDTNHKVFSSDHTNGSFVL 88 Query: 99 GRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEAL 158 L A P D+ R ++ + E+ I+ +L L Sbjct: 89 DDTTLNAVDGGIYLPNFLGMDPPKHDVHRMVVSPIVA-PQNLLRFEATIRERTKRVLSEL 147 Query: 159 RKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLY 218 G+ F+ + ++ L F ++D + L T W + Sbjct: 148 --PIGEEFNWVDRVSIELTTMMLATLL--DFPFDDRRKL--------------TRWSDII 189 Query: 219 NNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKH 278 P + L S + + E Y E P P DL L E + Sbjct: 190 TTRPGY--GLVDSWEQRESELMECLAYFQRLYAERQA--MPPKP-DLISMLAHSPEMQDL 244 Query: 279 SAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRI 338 + T+A L G +TT +++ + YP+ +K+ Sbjct: 245 TPT------DFLGTLALLIVGGNDTTRSSMSGSAMACHLYPQEFDKV------------- 285 Query: 339 PAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLY 398 R + +V+ E+ R+ T + +++ A D FRG I KG VV S Sbjct: 286 -----RNNRALLASVIPEVVRWQTPI-AHMRRTALEDVEFRGKQIRKGDKVVMWYLSGNR 339 Query: 399 DNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 D++ P F + + + F G C G LA ++L +L + + + Sbjct: 340 DDEVIDRPMDFIADRP--------RARHHLSFGFGIHRCLGNRLAELQLKILWEEMCERY 391 Query: 459 -NLKPLVDPKDIDLSPIHIGFGCIPPR 484 ++ +P + S + G+ IP R Sbjct: 392 SRIEVCGEPVRVP-SNLVHGYIDIPVR 417 >1WIY-A nrPDB Length = 389 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 72/431 (16%), Positives = 134/431 (31%), Gaps = 72/431 (16%) Query: 39 LPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFS 98 P + +L ++ + +F L + + ++ + V+ ALL + Sbjct: 10 WPYLKDL----QQDPLAVLLEWGRAHPRLF-LPLPRFPLALIFDPEGVEGALLAEGTTKA 64 Query: 99 GRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEAL 158 A RG++ + G +WK+ R+ +G ++ EA Sbjct: 65 TF-QYRALSRLTGRGLLTDWGKSWKEARKALKDPFL--PKSVRGYREAMEEEAWAFFGEW 121 Query: 159 RKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLY 218 R G+ D + ++ LF K Sbjct: 122 R---GEERDLDHEMLALSLRLLGRALFGK------------------------------- 147 Query: 219 NNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKH 278 P +K + + + + + +D H Sbjct: 148 -------PLSPSLAEHALKALDRIMAQTRSPLALLDLAAEARFRKDRGALYREAEALIVH 200 Query: 279 SAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRI 338 + L AG ET ++ L + L+L P+ ++++ E + + + Sbjct: 201 PPLSHLPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRVAESEEAALAAFQ- 259 Query: 339 PAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLY 398 E R L R + +P+GT +V + Sbjct: 260 -----------------EALRLYPPA-WILTRRLERPLLLGEDRLPQGTTLVLSPYVTQR 301 Query: 399 DNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 FP+ E F+PE FL E G S + PF G+R+C G A +E ++L A + F Sbjct: 302 --LYFPEGEAFQPERFLAERGT--PSGRYFPFGLGQRLCLGRDFALLEGPIVLRAFFRRF 357 Query: 459 NLKPLVDPKDI 469 L PL P+ + Sbjct: 358 RLDPLPFPRVL 368 >6G5O-A nrPDB Length = 399 Score = 126 bits (317), Expect = 2e-29, Method: Composition-based stats. Identities = 73/451 (16%), Positives = 144/451 (31%), Gaps = 82/451 (18%) Query: 48 LELKNIPKSF--TRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKD----EFSGRG 101 ++ +P F R ++ +G + + ++ +K V+++ +YK GR Sbjct: 1 MKKSELPDPFEKARESKGYGE---MNDQDDPVTMLLRHKDVRKSAHNYKTFQSGAVPGRI 57 Query: 102 DLPAFHAHRD-RGIIFN-NGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALR 159 +P+ RD R I F + P R K+ ++ Q + + + Sbjct: 58 VIPSEVDIRDTRQIPFEVDPPVHGVYRAIVEPWF------KRPLQAEYQEKLTAQISEIV 111 Query: 160 KTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYN 219 + + V+ D R R + L LL+TP+ + Sbjct: 112 E---------ETLLKGSVEVVTDFALRLQS--------RALTL------LLNTPFSESET 148 Query: 220 NFPSFLHYLPGSHRKVI-KNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKH 278 H + + Y+ E++ N D+ LL Sbjct: 149 WISWGTHVFRSEGEALDGDKANILYHYIDEQI----DRASENPGDDMYSVLL-----NSE 199 Query: 279 SAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRI 338 R T + + + F G +T + + L ++PE E+L +E Sbjct: 200 FEGRKLTKEEVKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRKE---------- 249 Query: 339 PAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLY 398 V E+ R+ + + + + T DT + + + + S Sbjct: 250 --------PEITGRAVEEMIRYFSPL-TQMGRVVTEDTHVCEHAVKADSRISLCWASANR 300 Query: 399 DNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458 D F +P + + +N + F C G AR L +LL + Q Sbjct: 301 DAAVFENPNEIVLDRKVNPH---------VGFGFSHHNCLGATHARQILKILLQTLAQKV 351 Query: 459 NLKPLVD----PKDIDLSPIHIGFGCIPPRY 485 ++D +D+D +GF I ++ Sbjct: 352 ASFEILDYKENIEDLDHFQRKVGFHNIQIKF 382 >2IJ7-A nrPDB Length = 396 Score = 125 bits (315), Expect = 3e-29, Method: Composition-based stats. Identities = 62/344 (18%), Positives = 113/344 (32%), Gaps = 62/344 (18%) Query: 128 FSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLI-GCAPCNVIADILFR 186 ++ G E ++ A+ LL+ L T+G P D + +L Sbjct: 94 LRKAVMKAITPKAPGLEQFLRDTANSLLDNLI-TEGAPADLRNDFADPLATALHCKVLGI 152 Query: 187 KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYV 246 D K R + + F S +P + +++ + + Sbjct: 153 PQED--GPKLFRSLSIA-----------------FMSSADPIPAAKINWDRDIEYMAGIL 193 Query: 247 SERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTV-ADLFFAGTETTS 305 ++T L+ E+ + + + D + T+ F AG +T Sbjct: 194 ENP--------------NITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTG 239 Query: 306 TTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVP 365 + L L+ L++ P++ LHE + + A V E+ R Sbjct: 240 SFLTTALISLIQRPQLRNLLHE------------------KPELIPAGVEELLRINLSFA 281 Query: 366 SNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSD 425 LP AT D L+ KG +V+ L+ +D + FP+P + + Sbjct: 282 DGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRP--------NPT 333 Query: 426 YFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDI 469 F G+ C G L R + + A+L+ L P D Sbjct: 334 SHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQ 377 >3WEC-A nrPDB Length = 419 Score = 125 bits (313), Expect = 5e-29, Method: Composition-based stats. Identities = 73/460 (15%), Positives = 128/460 (27%), Gaps = 88/460 (19%) Query: 50 LKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAV-KEALLDYKDEFSGRG------- 101 + + RL P+ +G+ + V + L +F+ Sbjct: 23 KADPYPVYARLRTEL-PIHRSALGAWIVADYTSCDKVLRSRLF--GKDFANSTFFDHLTS 79 Query: 102 ----DLPAFHAHRDRG----IIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHF 153 D+P F G + + P +R + + A Sbjct: 80 MMGEDMPPFLGLGIDGDARPFMLTDPPEHTRLRGLVSDAFTRS--TTTSMDDIVLSAASS 137 Query: 154 LLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTP 213 + L + + P V++ IL D F+E Sbjct: 138 AVRHLEHC---TDAVSEVAEPFPVEVLSSILGIPDKDRG---------RFSE-------- 177 Query: 214 WLQLYNNFPSFLHYLPG-SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVE 272 W L +P + + E +Y + N P L+ Sbjct: 178 WSNLVAGVLDINFAIPKEVADRRSAAIEESIDYFRTL------ATSGNAPE----GLVRR 227 Query: 273 MEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRV 332 + + H ++L ++D I T + AG ETTS T+ L+ ++ + E++ Sbjct: 228 LSEVSHGGDQL-SVDEIAATCLLITVAGQETTSNTIGNMLITFSRHADQFEQVRA----- 281 Query: 333 IGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPT 392 +++ V E+ RF A D G I KG V+ Sbjct: 282 -------------NPQFIENAVAEVLRFEPPAHEA-GRIALEDCEVSGANITKGDAVMVL 327 Query: 393 LDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLC 452 L S + + F + G C G LA L L Sbjct: 328 LASGNR--EAVERGDTFSVTR---------PDVSSLSYGRGIHHCLGSALANSMLQHFLR 376 Query: 453 AILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPR 492 + Q + + +P I+ P G G P + R Sbjct: 377 ELSQRYRSIEVAEP--INYKP---GMGLRGPETLSVAVSR 411 >5EX8-A nrPDB Length = 424 Score = 122 bits (305), Expect = 5e-28, Method: Composition-based stats. Identities = 71/398 (17%), Positives = 123/398 (30%), Gaps = 75/398 (18%) Query: 81 HGYKAVKEALLDYKDEFSGR---GDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYG 137 G V++ L D+FS R G A + + P +RR + + Sbjct: 85 TGIDEVRQVLG--SDKFSARLLYGGTAAGITWPGF-LTQYDPPEHTRLRRMVVPAFSHRR 141 Query: 138 MGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCN-VIADILFRKHFDYNDEKF 196 M Q R+++ L+ + ++ G P D G A D L D D Sbjct: 142 M--QKFRPRVEQIVQDSLDTI-ESLGGPVDFVPHFGWAIATPATCDFLGIPRDDQADLAR 198 Query: 197 LRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQS 256 + L + S ++ + Y+ + V + + Sbjct: 199 ILLASRTDR-------------------------SDKRRTAAGNKFMTYMKQHVAQSRRG 233 Query: 257 LDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILM 316 D L + +E A T +T A + A + + L G +++ Sbjct: 234 S--------GDDLFGIVGRENGDA---ITDAELTGVAAFVMGAAADQVARLLAAGAWLMV 282 Query: 317 KYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDT 376 + P L E+ P +P D E R++T P AT+D Sbjct: 283 EQPAQFALLREK------PETVPEWLD------------ETMRYLTTDEKTHPRVATQDV 324 Query: 377 IFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRV 436 L+ G V +L + ++F E+ F G Sbjct: 325 RIGNQLVKAGDTVTCSLLAANR-PNYPSAEDEFDITREKAEH---------LAFGHGIHH 374 Query: 437 CAGEGLARMELFLLLCAILQHFNLKPLVDP-KDIDLSP 473 C G +A + + + A+ F L DP ++I L P Sbjct: 375 CLGRAMAELMFKVSIPALAHRFPTLRLADPQREITLGP 412 >6G71-A nrPDB Length = 405 Score = 118 bits (295), Expect = 7e-27, Method: Composition-based stats. Identities = 66/390 (16%), Positives = 117/390 (30%), Gaps = 59/390 (15%) Query: 80 MHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMG 139 + Y V A +D + A ++ + P + RR +L+ G Sbjct: 47 ITSYSGVLAADVDQTTFSANEKKSLMLRAM-GHSMLRKDDPDHQVERRAWQPSLKP-GTV 104 Query: 140 KQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL 199 K+ + + A L+A G D + LR Sbjct: 105 KKVWKQKFAENADRYLDAYIDA-GSGSDFMQGFAAPFV----------------AENLRA 147 Query: 200 MYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDP 259 + F W Q + P K ++ E+ + E ++ H Sbjct: 148 LIGFENASEADLQRWSQTLIDGAGNYPDDPDVWAKAKQSSDEIDAALEEMIQWHSGR--- 204 Query: 260 NCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYP 319 D LL + + SA+ ++ I + G L L L+ Sbjct: 205 -----PGDSLLSYLLR---SADYQMPLESIRSNIKMTIGGGLNEPRDVLGVSTLALLSSS 256 Query: 320 EIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFR 379 + E + ++ AV E R++ + +P + DT Sbjct: 257 KQLELV------------------LRDPKLWGAVFEESIRWVAPI-GMVPRQTVVDTELD 297 Query: 380 GYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAG 439 GY IP+G + + S D + DP++F E S+ F G VC G Sbjct: 298 GYFIPRGAKLGLCILSANRDRSVWSDPDRFDIER---------GSEAHLAFGKGVHVCLG 348 Query: 440 EGLARMELF-LLLCAILQHFNLKPLVDPKD 468 AR ++ + L A+ L ++ Sbjct: 349 AWAARSQVADVGLPALFSRLKGLRLDPNQE 378 >5D3U-A nrPDB Length = 427 Score = 117 bits (294), Expect = 1e-26, Method: Composition-based stats. Identities = 59/394 (14%), Positives = 107/394 (27%), Gaps = 67/394 (17%) Query: 97 FSGRGDLP--AFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFL 154 F G+ P FH +++ + P +RR Q + +Q+ AH L Sbjct: 89 FPGQPLPPDNIFHRWTKNVVMYTDPPLHDALRRSVRAGFTR--AAHQHYDQVLQKVAHDL 146 Query: 155 LEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPW 214 + + G + + + + F + Sbjct: 147 VA------------SIPAGATEIDAVPAL-----------AAELPVRSAVHAFGVPEEDL 183 Query: 215 LQLYNNFPSFLHYLPGSHRK------VIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDC 268 L + + Y G + +++ + ++ Y SE ++ + P D Sbjct: 184 GFLIPRVNTIMTYFSGPKDQPVTQEIILEKLTDLHTYASELLQGMRGKVLP----DTVIA 239 Query: 269 LLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEE 328 L + T+ + + LF TT +L G L + P E+ + Sbjct: 240 RLAAAQDGLTETTPEQTVHQLALVFIALFAP---TTPGSLSSGTLAFARNPRQVERFLAD 296 Query: 329 IDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTV 388 V D +E+ R+ A +D G I G Sbjct: 297 QACV------------------DNTANEVLRYNASNQFTW-RVAAKDVEMGGVRIEAGQT 337 Query: 389 VVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELF 448 + L S D F P F + S F G C L ++L Sbjct: 338 LALFLGSANRDANMFERPNDFDLDRP--------NSARHLSFGQGVHACLAAQLISLQLK 389 Query: 449 LLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIP 482 A+L F + + +P Sbjct: 390 WFYVALLNRFPGIRTAGEPIWNENLEFRSLRSLP 423 >4FB2-A nrPDB Length = 398 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 59/438 (13%), Positives = 114/438 (26%), Gaps = 91/438 (20%) Query: 48 LELKNIPKSFTR------------LAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKD 95 L P +F ++ +G + V+ GYK + +A++ Sbjct: 15 LGPDGTPHAFFEALRDEAETTPIGWSEAYGGHW----------VVAGYKEI-QAVIQNTK 63 Query: 96 EFSGRGDLPAFHAHRDRGIIFN--NGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHF 153 FS +G + + ++ + P K R+ Sbjct: 64 AFSNKGVTFPRYETGEFELMMAGQDDPVHKKYRQLVAKPFSP-------------EATDL 110 Query: 154 LLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTP 213 E LR++ D +G D + L Sbjct: 111 FTEQLRQSTNDLIDARIELG--------------EGDAATWLANEIPARLTAILLGLPPE 156 Query: 214 WLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEM 273 Y + + ++ + + AE+ + + E + + ++ + Sbjct: 157 DGDTYRRWVWAITHVENP-EEGAEIFAELVAHARTLIAERRT--------NPGNDIMSRV 207 Query: 274 EKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI 333 K E L D I L G + T+ L L E+ +L Sbjct: 208 IMSKIDGESLSEDDLIGFFTI-LLLGGIDNTARFLSSVFWRLAWDIELRRRLIA------ 260 Query: 334 GPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTL 393 + V E+ RF P+ + T++ + G + Sbjct: 261 ------------HPELIPNAVDELLRFY--GPAMVGRLVTQEVTVGDITMKPGQTAMLWF 306 Query: 394 DSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCA 453 D F P+ E N + G C G L R+E + + Sbjct: 307 PIASRDRSAFDSPDNIVIERTPNRHLSL---------GHGIHRCLGAHLIRVEARVAITE 357 Query: 454 ILQHFNLKPLVDPKDIDL 471 L+ L K+ + Sbjct: 358 FLKRIPEFSLDPNKECEW 375 >2WIY-A nrPDB Length = 394 Score = 112 bits (279), Expect = 4e-25, Method: Composition-based stats. Identities = 38/238 (15%), Positives = 74/238 (31%), Gaps = 32/238 (13%) Query: 245 YVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETT 304 Y+S RV E + N L D LL + + T+ + G Sbjct: 185 YLSARVAEMLEDKRVNPGDGLADSLLDAARAGEITES------EAIATILVFYAVGHMAI 238 Query: 305 STTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLV 364 + G+ + + PE+ + A+++E+ R Sbjct: 239 GYLIASGIELFARRPEVFTAFRNDESARA------------------AIINEMVRMDPP- 279 Query: 365 PSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYS 424 + T D G LI G+ + + + D + F DP+ F + Sbjct: 280 QLSFLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTRPP-------AA 332 Query: 425 DYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIP 482 F G CAG+ ++R E + + + + L + + + + +P Sbjct: 333 SRNLSFGLGPHSCAGQIISRAEATTVFAVLAERYERIELAEEPTVAHNDFARRYRKLP 390 >3BUJ-A nrPDB Length = 397 Score = 111 bits (278), Expect = 6e-25, Method: Composition-based stats. Identities = 65/387 (16%), Positives = 120/387 (31%), Gaps = 70/387 (18%) Query: 69 TLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRG---------IIFNNG 119 ++ G+ R+ + + V+ L D + F+ G + G I+F + Sbjct: 27 PVHRGAHRVWYVSRFADVRAVLGD--ERFARTGIRRFWTDLVGPGLLAEIVGDIILFQDE 84 Query: 120 PTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNV 179 P +R + + E I LL + +V Sbjct: 85 PDHGRLRGVVGPAFSPSAL--RRLEPVIAGTVDDLL-------------RPALARGAMDV 129 Query: 180 IADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNV 239 + ++ + L L+ L ++ + + R+ + Sbjct: 130 VDEL----AYPLALRAVLGLLGLPAADWGAVGRWSRDVGRTLD--RGASAEDMRRGHAAI 183 Query: 240 AEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFA 299 AE +Y V+ DL +L ++ L + + I TV F Sbjct: 184 AEFADY----VERALARRRREGGEDLLALMLDAHDRG------LMSRNEIVSTVVTFIFT 233 Query: 300 GTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQR 359 G ET ++ + +L L+ +P+ + L R+ + V E R Sbjct: 234 GHETVASQVGNAVLSLLAHPDQLDLL------------------RRRPDLLAQAVEECLR 275 Query: 360 FITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENG 419 + V SN + D RG + + VVV + D + + P+ F E + Sbjct: 276 YDPSVQSNT-RQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDFDIERDPVPS- 333 Query: 420 KFKYSDYFKPFSTGKRVCAGEGLARME 446 F G R C G LAR + Sbjct: 334 --------MSFGAGMRYCLGSYLARTQ 352 >5OMS-A nrPDB Length = 409 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 57/406 (14%), Positives = 116/406 (28%), Gaps = 52/406 (12%) Query: 51 KNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHR 110 +N + + RL F +GS V + +E + +F Sbjct: 24 RNPYEVYERLRAEAPLAFVPVLGSY---VASTAEVCRE--VATSPDFEAVITPAGGRTFG 78 Query: 111 DRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTF 170 II NG D+R L+ + + + ++ A LE + G Sbjct: 79 HPAIIGVNGDIHADLRSMVEPALQPAEV-DRWIDDLVRPIARRYLERF-ENDGHAELVAQ 136 Query: 171 LIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPG 230 + D+L + D + L L + + F + P Sbjct: 137 YCEPVSVRSLGDLLGLQEVDSD--------KLREWFAKLNRSFTNAAVDENGEFAN--PE 186 Query: 231 SHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGIT 290 + + AE++ V + D + + + + I Sbjct: 187 GFAEGDQAKAEIRAVVDPLI--------DKWIEHPDDSAISHWLHDGMPPGQTRDREYIY 238 Query: 291 VTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM 350 T+ + + L+ L PE E++ + + Sbjct: 239 PTIYVYLLGAMQEPGHGMASTLVGLFSRPEQLEEV------------------VDDPTLI 280 Query: 351 DAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFK 410 + E R+ + + S +T+ G +P GT V+ + S +D ++ P ++ Sbjct: 281 PRAIAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTPVMLSYGSANHDTGKYEAPSQYD 340 Query: 411 PEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQ 456 + F G CAG A + + L + + Sbjct: 341 LHRPPLPH---------LAFGAGNHACAGIYFANHVMRIALEELFE 377 >2QBO-A nrPDB Length = 421 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 72/404 (17%), Positives = 119/404 (29%), Gaps = 68/404 (16%) Query: 84 KAVKEALLDYKDEFSGRGDLPAFHAHRDRGI-IFNNGPTWKDIRRFSLTTLRNYGMGKQG 142 + ++EA DY+ S +P I + P + R + + Sbjct: 70 QLIREAYEDYRHFSSECPFIPREAGEAYDFIPTSMDPPEQRQFRALANQVVGMP--VVDK 127 Query: 143 NESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYL 202 E+RIQ A L+E+LR QGQ P + + D K+L Sbjct: 128 LENRIQELACSLIESLR-PQGQCNFTEDYAEPFPIRIFMLLAGLPEEDIPHLKYLTDQM- 185 Query: 203 FNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCP 262 P + + +Y+ +++ Sbjct: 186 ------------------------TRPDGSMTFAEAKEALYDYLIPIIEQRR-------- 213 Query: 263 RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE 322 + + + + + R T D L G +T L + + L K PE Sbjct: 214 QKPGTDAISIVANGQVNG-RPITSDEAKRMCGLLLVVGLDTVVNFLSFSMEFLAKSPEHR 272 Query: 323 EKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYL 382 ++L E P RIP A E+ R +LV T D F G Sbjct: 273 QELIE------RPERIP------------AACEELLRRFSLVADG--RILTSDYEFHGVQ 312 Query: 383 IPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGL 442 + KG ++ D +E P + F G +C G+ L Sbjct: 313 LKKGDQILLPQMLSGLDERENACPMHVDFSRQKVSHTT---------FGHGSHLCLGQHL 363 Query: 443 ARMELFLLLCAILQHF-NLKPLVDPKDIDLSPIHIGFGCIPPRY 485 AR E+ + L L + + S I G +P + Sbjct: 364 ARREIIVTLKEWLTRIPDFSIAPGAQIQHKSGIVSGVQALPLVW 407 >5KYO-A nrPDB Length = 430 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 60/369 (16%), Positives = 104/369 (28%), Gaps = 68/369 (18%) Query: 115 IFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGC 174 + + P + R L + + E + A L+E R F F Sbjct: 123 LSLDPPEHRPFRSLLNENLGPKPL--RPIEQVVTDLAVSLIEGFRPKGRCNFTHEFAEQL 180 Query: 175 APCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRK 234 F+R++ L E+ L Q + P Sbjct: 181 PVRI-----------------FMRIVDLPVEDLPKLKHLADQ---------YTRPDGSIP 214 Query: 235 VIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVA 294 + + +EY+ ++ D+ ++ R T Sbjct: 215 LDDVTKQFREYLRPVIEARR----IKPGEDMISRMI-----NGEVGGRPLTDIEAENICI 265 Query: 295 DLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVV 354 + G +T L + L K + + + +D + Sbjct: 266 QVLVGGLDTVVNMLGFTFSHLAKDHALRRAIAAD------------------PSLIDDAL 307 Query: 355 HEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHF 414 E R +V S E RD F G L+ G +V+ V D+ DP +F+ Sbjct: 308 LEFFRRFPVVSSA--REVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDPLEFRLGRK 365 Query: 415 LNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPI 474 ++ F G C G LARME+ ++L + D D L Sbjct: 366 ARQHST---------FGKGSHTCPGAHLARMEMKVVLREWFARIPEFRIED--DAPLRYS 414 Query: 475 HIGFGCIPP 483 + G + P Sbjct: 415 NGIVGSVKP 423 >3B98-A nrPDB Length = 475 Score = 108 bits (270), Expect = 5e-24, Method: Composition-based stats. Identities = 93/507 (18%), Positives = 166/507 (32%), Gaps = 75/507 (14%) Query: 22 MWRQVHS--------SWNLPP---GPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTL 70 M ++ S N PP G P +G+ + K+ K TR+ ++ G +FT+ Sbjct: 1 MAKKTSSVLYGRRTRRRNEPPLDKGMIPW--LGHALEFG-KDAAKFLTRMKEKHGDIFTV 57 Query: 71 YVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIF-NNGPTWKDIR--- 126 + V+ L D + R +I ++ P + R Sbjct: 58 RAAGLYITVLLDSNCYDAVLSDVASL--DQTSYAQVLMKRIFNMILPSHNPESEKKRAEM 115 Query: 127 RFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFR 186 F +L Q N + + L+ + F N+ +LF+ Sbjct: 116 HFQGASLTQLSNSMQNNLRLLMTPSEMGLKTSEWKKDGLF-----------NLCYSLLFK 164 Query: 187 KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRK-VIKNVAEVKEY 245 + + +F + S Q+Y F F LP R V K ++ Sbjct: 165 TGY----------LTVFGAENNN-SAALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASA 213 Query: 246 VSERVKEHHQ-SLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETT 304 E++ + S PR+ L K+ M + + G Sbjct: 214 AREKLWKWLTPSGLDRKPRE--QSWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQGN--A 269 Query: 305 STTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLV 364 + + L+ +PE + EEI G + + ++ P D+V+ E R Sbjct: 270 GPAAFWVMGYLLTHPEALRAVREEIQ---GGKHLRLEERQKNTPVFDSVLWETLRLT--A 324 Query: 365 PSNLPHEATRDTIF-----RGYLIPKGTVVVPTLD-SVLYDNQEFPDPEKFKPEHFLNEN 418 + + + T+D + Y + +G + S D Q PE F+ + FLN + Sbjct: 325 AALITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNAD 384 Query: 419 GKFKY---------SDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDI 469 K P+ T +C G A + L+ IL F+++ + Sbjct: 385 RTEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATV 444 Query: 470 DL-SPIHIGFGCIPP------RYKLCV 489 L P GFG + P RY++ Sbjct: 445 PLVDPSRYGFGILQPAGDLEIRYRIRF 471 >6FYJ-A nrPDB Length = 421 Score = 105 bits (263), Expect = 4e-23, Method: Composition-based stats. Identities = 69/427 (16%), Positives = 137/427 (32%), Gaps = 67/427 (15%) Query: 66 PVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGR---GDLPAFHAHRDRGIIFNNGPTW 122 +F + ++ + M G +A E D + F + + G+ +G T Sbjct: 39 DIFETRLLGKKAICMGGKEAA-EIFYDTEK-FKRKDAAPNRVVQTLFGKNGVQALDGQTH 96 Query: 123 KDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIAD 182 K + ++ + + K + ++ Q E + + Q C Sbjct: 97 KHRKEMFMSIMSPDELEKLTDITKKQWE----IAVDKWEQMDKVILYEEAKEIMCRTACQ 152 Query: 183 ILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEV 242 + ++ + + E+ + L + +N E+ Sbjct: 153 WAGVPVQENEVKRLTKNLGAMFESAAAVG----------------LKHWLGRHARNYEEI 196 Query: 243 KEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLF---FA 299 ++ E + + + N P + T L + + L + V V ++ A Sbjct: 197 --WIEELI-DRVRDGKVNPPENTT---LHKFSWYRDLEGNLLDTETAAVEVINILRPIVA 250 Query: 300 GTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQR 359 + + + L L YPE +EKL + Y V E++R Sbjct: 251 ----IAIFINFIALALHHYPEEKEKLKS-----------------GDKKYSQMFVQEVRR 289 Query: 360 FITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENG 419 F P + +D ++GY +GT+ + L +D + + +P+ F P+ F G Sbjct: 290 FYPFFPFVVA-LVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRFAKWEG 348 Query: 420 KFKYSDYFKPFSTGK----RVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIH 475 F P G CAGE + + + L + + + D DLS Sbjct: 349 S---PFSFIPQGGGDYFMGHRCAGEWVTIEVMKVSLDYLTNRMDYE----VPDQDLSFSM 401 Query: 476 IGFGCIP 482 IP Sbjct: 402 ASMPSIP 408 >5M0P-A nrPDB Length = 428 Score = 104 bits (260), Expect = 7e-23, Method: Composition-based stats. Identities = 66/431 (15%), Positives = 126/431 (29%), Gaps = 77/431 (17%) Query: 67 VFTLY-VGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHR----DRGIIFNNGPT 121 VF +G + VV+ G + + Y ++ R + I +G Sbjct: 41 VFQTKALGGKPFVVVTGKEGAEMF---YNNDVVQREGMLPKRIVNTLAGKGAIHTVDGKK 97 Query: 122 WKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIA 181 D + ++ + + L L Q + + +++ Sbjct: 98 HVDRKALFMSLMTEGNLN----------YVRELTRTLWHANTQRMESMDEVNIYRESIVL 147 Query: 182 DILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAE 241 ++ E + + S + Sbjct: 148 LTKVGTR-----WAGVQAPPEDIERIATDMDIMIDSFRALGGAFKGYKASK----EARRR 198 Query: 242 VKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGT 301 V++++ E++ E + + + H + L DL Sbjct: 199 VEDWLEEQIIETRKGNIHPPEG-------TALYEFAHWEDYLGNPMDSRTCAIDLM---- 247 Query: 302 ETTSTTL------RYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVH 355 T + +GL + + P EK+ E D Y Sbjct: 248 NTFRPLIAINRFVSFGLHAMNENPITREKIKSEPD------------------YAYKFAQ 289 Query: 356 EIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFL 415 E++R+ VP LP +A D F+G IP G + + +D + DP +F+PE F Sbjct: 290 EVRRYYPFVPF-LPGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRPERFE 348 Query: 416 NENGKFKYSDYFKPFSTG----KRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDL 471 +G P G CAGE + +++ +++F K D + DL Sbjct: 349 TWDGS---PFDLIPQGGGDYWTNHRCAGEWIT----VIIMEETMKYFAEKITYDVPEQDL 401 Query: 472 SPIHIGFGCIP 482 + IP Sbjct: 402 ---EVDLNSIP 409 >2IAG-A nrPDB Length = 482 Score = 97.1 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 86/502 (17%), Positives = 166/502 (33%), Gaps = 63/502 (12%) Query: 25 QVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYK 84 + P +P +G K+ TR+ ++ G +FT+ VG + + V+ Sbjct: 1 RTRRPGEPPLDLGSIPWLGYALDFG-KDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPH 59 Query: 85 AVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNE 144 + + + + R D A+ I P + + Sbjct: 60 SYDAVVWEPRT----RLDFHAYAIFLMERIFDVQLPHY-----------SPSDEKARMKL 104 Query: 145 SRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFN 204 + + RE L EA+ + + + + F F LR YL Sbjct: 105 TLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSF------LLRAGYLTL 158 Query: 205 ENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEV-KEYVSERVKEHHQSLDPNCPR 263 L + + R++ + + ++ + +S K+H S+ + Sbjct: 159 YGIEALPRTHESQAQDRVHSADVF-HTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWK 217 Query: 264 DLTDCLLVEME-KEKHSAERLYTMDGITVT-------VADLFFAGTETTSTTLRYGLLIL 315 L+ L + K L ++ + V+ + +A + LL L Sbjct: 218 LLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFL 277 Query: 316 MKYPEIEEKLHEEIDRVIGPSRIP-------AIKDRQEMPYMDAVVHEIQRFITLVPSNL 368 +K PE + E++ ++ + P K P +D+V+ E R + Sbjct: 278 LKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLT--AAPFI 335 Query: 369 PHEATRDTIF-----RGYLIPKGTVVVPTL-DSVLYDNQEFPDPEKFKPEHFLNENGKFK 422 E D R + + +G ++ S D + + DPE FK FLN +G K Sbjct: 336 TREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEK 395 Query: 423 Y---------SDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL-VDPKDIDLS 472 +Y P+ G C G A + + +L H +L+ + D + + Sbjct: 396 KDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFD 455 Query: 473 PIHIGFGC------IPPRYKLC 488 GFG +P RY++ Sbjct: 456 LSRYGFGLMQPEHDVPVRYRIR 477 >3NV6-A nrPDB Length = 452 Score = 96.3 bits (238), Expect = 2e-20, Method: Composition-based stats. Identities = 66/409 (16%), Positives = 130/409 (31%), Gaps = 66/409 (16%) Query: 84 KAVKEALLDYKDEFSGRGDLPAFHAHRDRGI-IFNNGPTWKDIRRFSLTTLRNYGMGKQG 142 VKE D S LP + + + + P R+ L + + Sbjct: 105 DTVKEVYSDPTRFSSEVIFLPKEAGEKYQMVPTKMDPPEHTPYRKALDKGLNLAKI--RK 162 Query: 143 NESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYL 202 E +++ A L+++ +G+ P +V + + L + + Sbjct: 163 VEDKVREVASSLIDSFA-ARGECDFAAEYAELFPVHVFMALA---------DLPLEDIPV 212 Query: 203 FNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCP 262 +E ++ P + L YV ++ Sbjct: 213 LSEYARQMTRPEGNTPEEMATDLE----------AGNNGFYAYVDPIIRARVGG------ 256 Query: 263 RDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIE 322 D L+ M + + ER+ D ++ L G +T L + ++ L ++PE+ Sbjct: 257 --DGDDLITLMVNSEINGERIA-HDKAQGLISLLLLGGLDTVVNFLSFFMIHLARHPELV 313 Query: 323 EKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYL 382 +L + +++ + E+ R +V +D ++G Sbjct: 314 AELRSDPLKLMRGA------------------EEMFRRFPVVSEA--RMVAKDQEYKGVF 353 Query: 383 IPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGL 442 + +G +++ D+ P+P K S F G CAG L Sbjct: 354 LKRGDMILLPTALHGLDDAANPEPWKLDFSRR---------SISHSTFGGGPHRCAGMHL 404 Query: 443 ARMELFLLLCAILQH---FNLKPLVDPKDIDLSPIHIGFGCIPPRYKLC 488 ARME+ + L L+ F+ K P I S I +P + + Sbjct: 405 ARMEVIVTLEEWLKRIPEFSFKEGETP--IYHSGIVAAVENVPLVWPIA 451 >5YHJ-A nrPDB Length = 413 Score = 95.9 bits (237), Expect = 4e-20, Method: Composition-based stats. Identities = 64/430 (14%), Positives = 139/430 (32%), Gaps = 75/430 (17%) Query: 67 VFTLYVGSQRMVVMHGYKAVKEALLDYKD----EFSGRGDLPAFHAHRDRGIIFNNGPTW 122 +F + +R++ + G +A E D + + + L + G+ +G Sbjct: 36 IFESRLLGERVICLGGEEAA-EVFYDANKFTRQDAAPKRLLKT--LFGEGGVQTLDGSEH 92 Query: 123 KDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEAL--RKTQGQPFDPTFLIGCAPCNVI 180 ++ ++ + + I R + G+ + + Sbjct: 93 THRKQMFMSLMT---------KENIDRLLRLTYREWNQIERMGEEIVLYDIAQEVLMKAV 143 Query: 181 ADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA 240 + K M L E+ L ++ + K + Sbjct: 144 CEWSGVPLAKEEVGKRTEEMRLLFESGTSLG------------------PTYLQGRKARS 185 Query: 241 EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG 300 + ++ + VKE + L E + + L + + V V ++ Sbjct: 186 SAEVWIRQMVKEVRSNRLLPNEH----TALYEFSWHRDESGELLPEEVVAVEVLNILRP- 240 Query: 301 TETTSTTL--RYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQ 358 T + ++ + +L L ++P+++E++ +R E+ + V E++ Sbjct: 241 --TVAISVYVLFTVLALHQFPDVKEQV-----------------ERGEVSKTE-FVQEVR 280 Query: 359 RFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNEN 418 RF P T D + GY P+GT+ + L +D + +P++F P F + Sbjct: 281 RFYPFFPVAAARVKT-DFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSRFKDWK 339 Query: 419 GKFKYSDYFKPFSTGK----RVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPI 474 F P G CAGE + +L +++ F + DLS Sbjct: 340 ES---PFNFIPQGGGDVDFGHRCAGEHVTIA----ILAQVIELFTKEYAYTVPPQDLSYS 392 Query: 475 HIGFGCIPPR 484 + +P Sbjct: 393 FVDMPSLPKS 402 >3AWQ-A nrPDB Length = 415 Score = 91.7 bits (226), Expect = 6e-19, Method: Composition-based stats. Identities = 35/145 (24%), Positives = 57/145 (39%), Gaps = 12/145 (8%) Query: 344 RQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF 403 Q+ Y + V E++RF P+ + A++D + G P+G VV L +D + Sbjct: 268 VQQPDYAELFVQEVRRFYPFFPAVVAR-ASQDFEWEGMAFPEGRQVVLDLYGSNHDAATW 326 Query: 404 PDPEKFKPEHFLNENGKFKYSDYFKPFSTGK----RVCAGEGLARMELFLLLCAILQHFN 459 DP++F+PE F + S F P G C GE + + + ++ Sbjct: 327 ADPQEFRPERFRAWDED---SFNFIPQGGGDHYLGHRCPGEWIVLAIMKVAAHLLVNAMR 383 Query: 460 LKPLVDPKDIDLSPIHIGFGCIPPR 484 D D DLS +P Sbjct: 384 ----YDVPDQDLSIDFARLPALPKS 404 >2ZQJ-A nrPDB Length = 417 Score = 89.0 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 60/457 (13%), Positives = 129/457 (28%), Gaps = 75/457 (16%) Query: 42 IGNLFQLELKNIPKSFTRLAQRF-GPVFTLYVGSQRMVVMHGYKAVKEAL----LDYKDE 96 + N L + +R+ +F + + + M G +A K ++ Sbjct: 11 LDNSLTLLKEG-YLFIKNRTERYNSDLFQARLLGKNFICMTGAEAAKVFYDTDRFQRQNA 69 Query: 97 FSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLE 156 R F + +G+ +G + L+ + +R A + E Sbjct: 70 LPKRVQKSLFGVNAIQGM---DGSAHIHRKMLFLSLMTP---------PHQKRLAELMTE 117 Query: 157 AL-----RKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLS 211 R + C V + + L + Sbjct: 118 EWKAAVTRWEKADEVVLFEEAKEILCRVAC--------------YWAGVPLKETEVKERA 163 Query: 212 TPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLV 271 ++ + + F + H K + +E++ +++ L + Sbjct: 164 DDFIDMVDAFGAVGP----RHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMAF 219 Query: 272 EMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDR 331 +++ + + + + S L + L L ++P+ +E L R Sbjct: 220 HTQEDGSQLDSRMAAIELINVLRPIVA-----ISYFLVFSALALHEHPKYKEWLRSGNSR 274 Query: 332 VIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVP 391 + V E++R+ P L +D ++ KGT V+ Sbjct: 275 ER-----------------EMFVQEVRRYYPFGPF-LGALVKKDFVWNNCEFKKGTSVLL 316 Query: 392 TLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGK----RVCAGEGLARMEL 447 L +D + + P++F+PE F P G C GEG+ + Sbjct: 317 DLYGTNHDPRLWDHPDEFRPERFAEREENL---FDMIPQGGGHAEKGHRCPGEGITIEVM 373 Query: 448 FLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR 484 L ++ D + L +P Sbjct: 374 KASLDFLVHQIE----YDVPEQSLHYSLARMPSLPES 406 >4C9K-A nrPDB Length = 421 Score = 87.1 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 68/402 (16%), Positives = 117/402 (29%), Gaps = 67/402 (16%) Query: 90 LLDYKDEFSGRGDLPAFHAHRDRGII--FNNGPTWKDIRRFSLTTLRNYGMGKQGNESRI 147 + + FS R A ++ + P R+ L + + E +I Sbjct: 76 IYRSPERFSSRVIWVPREAGEAYDMVPTKLDPPEHTPYRKAIDKGLNLAEI--RKLEDQI 133 Query: 148 QREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENF 207 + A ++E G G V +F E +L L NE Sbjct: 134 RTIAVEIIE------GFADRGHCEFGSEFSTVFPVRVFLALAGLPVEDATKLGLLANEMT 187 Query: 208 HLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTD 267 + R + EYV+ + DL Sbjct: 188 RPSGNTPEEQ--------------GRSLEAANKGFFEYVAPIIAARRG----GSGTDLIT 229 Query: 268 CLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHE 327 +L + D V+ L G +T L + ++ L ++PE ++ Sbjct: 230 RILNV-----EIDGKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSRHPETVAEMRR 284 Query: 328 EIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGT 387 E + + V E+ R +V D F G ++ +G Sbjct: 285 EPLK------------------LQRGVEELFRRFAVVSDA--RYVVSDMEFHGTMLKEGD 324 Query: 388 VVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMEL 447 +++ D++ DP + F+ G CAG LAR+E+ Sbjct: 325 LILLPTALHGLDDRHHDDPMTVDLSRRDVTHST---------FAQGPHRCAGMHLARLEV 375 Query: 448 FLLLCAILQH---FNLKPLVDPKDIDLSPIHIGFGCIPPRYK 486 ++L L F LK P I S I IP ++ Sbjct: 376 TVMLQEWLARIPEFRLKDRAVP--IYHSGIVAAVENIPLEWE 415 >2RCM-A nrPDB Length = 495 Score = 76.7 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 30/152 (19%), Positives = 58/152 (38%), Gaps = 13/152 (8%) Query: 320 EIEEKLHEEIDRVIGPSR-IPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIF 378 ++ +L EEI VI + + ++M +VV+E RF V + A +D + Sbjct: 316 QVHNRLAEEIRSVIKSNGGELTMGAIEKMELTKSVVYECLRFEPPVTAQYGR-AKKDLVI 374 Query: 379 RGYL----IPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFS--- 431 + + G ++ D + F ++F PE F+ E G+ Sbjct: 375 ESHDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEEGEKLLRHVLWSNGPET 434 Query: 432 ----TGKRVCAGEGLARMELFLLLCAILQHFN 459 G + CAG+ + L + I + ++ Sbjct: 435 ETPTVGNKQCAGKDFVVLVARLFVIEIFRRYD 466 >3DBM-A nrPDB Length = 473 Score = 65.5 bits (158), Expect = 5e-11, Method: Composition-based stats. Identities = 77/466 (16%), Positives = 148/466 (31%), Gaps = 69/466 (14%) Query: 34 PGPFPLPIIGNL-----FQLELKNIPKSFTRLAQRF-GPVFTLYV------GSQRMVVMH 81 PG + +P + + + F Q++ VF + S V++ Sbjct: 12 PGSYGIPFFQPIKDRLEYFYGTGGRDEYFRSRMQKYQSTVFRANMPPGPFVSSNPKVIVL 71 Query: 82 GYKAVKEALLD-----YKDEFSG--RGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLR 134 L D KD F+G +R + + P ++ L+ Sbjct: 72 LDAKSFPILFDVSKVEKKDLFTGTYMPSTKLTGGYRVLSYLDPSEPRHAQLKNLLFFMLK 131 Query: 135 NYGMGKQG-NESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYND 193 N E+ L L K F+ L R +F+ N Sbjct: 132 NSSNRVIPQFETTYTELFEGLEAELAKNGKAAFNDVGEQAAF------RFLGRAYFNSNP 185 Query: 194 EKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPG----SHRKVIKNVAEVKEYVSER 249 E+ + L + W+ L+N P+ LP + A + + + Sbjct: 186 EE-----TKLGTSAPTLISSWV-LFNLAPTLDLGLPWFLQEPLLHTFRLPAFLIKSTYNK 239 Query: 250 VKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETT-STTL 308 + ++ QS+ V + EK + + I V F G + TL Sbjct: 240 LYDYFQSVATP----------VMEQAEKLGVPKDEAVHNILFAVCFNTFGGVKILFPNTL 289 Query: 309 RYGLLILMKYPEIEEKLHEEIDRVIGP--SRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 366 ++ L + + L EEI I ++ ++MP +VV+E R VP Sbjct: 290 KWIGLA-GENLHTQ--LAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVVYESLRIEPPVPP 346 Query: 367 NLPHEATRDTIFRGYL----IPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFK 422 +A + + + KG ++ D + F PE++ P+ F+ + Sbjct: 347 QYG-KAKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRFVGDGEALL 405 Query: 423 YSDYFKPFSTGK---------RVCAGEGLARMELFLLLCAILQHFN 459 ++ S G + CAG+ + L + + + ++ Sbjct: 406 KYVWW---SNGPETESPTVENKQCAGKDFVVLITRLFVIELFRRYD 448 >2YJN-B nrPDB Length = 381 Score = 59.3 bits (142), Expect = 3e-09, Method: Composition-based stats. Identities = 21/130 (16%), Positives = 46/130 (35%), Gaps = 19/130 (14%) Query: 297 FFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHE 356 FAG E T+ T+ +L + P + E++ ++ V E Sbjct: 220 LFAGAEMTANTVVDAVLAVSAEPGLAERIADDPAA------------------AQRTVAE 261 Query: 357 IQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLN 416 + R + AT + ++I +G VV + + D + F +P++ + Sbjct: 262 VLRLHPALHLE-RRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVDRPDA 320 Query: 417 ENGKFKYSDY 426 + + + Sbjct: 321 DRALSAHRGH 330 >3APY-A nrPDB Length = 310 Score = 34.3 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 42/269 (15%), Positives = 80/269 (29%), Gaps = 34/269 (12%) Query: 60 LAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNG 119 L R GP+F+ + + +EAL +E + G Sbjct: 7 LKARRGPLFSFEFFPPK-----DPEG-EEALFRTLEELKAFRPAFVSITYGAMGSTRERS 60 Query: 120 PTW-KDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLE----ALRKTQGQP------FDP 168 W + I+ L L + + Q + + H +E L +G P F P Sbjct: 61 VAWAQRIQSLGLNPLAHLTVAGQSRKE-VAEVLHRFVESGVENLLALRGDPPRGERVFRP 119 Query: 169 TFLIGCAPCNVIADI---------LFRKHFDYNDEKFLRLMYLFN----ENFHLLSTPWL 215 ++A I + + + L + L Sbjct: 120 HPEGFRYAAELVALIRERYGDRVSVGGAAYPEGHPESESLEADLRHFKAKVEAGLDFAIT 179 Query: 216 QLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEK 275 QL+ N + +L + R I + + + C + LL ++E+ Sbjct: 180 QLFFNNAHYFGFLERARRAGIGIPI-LPGIMPVTSYRQLRRFTEVCGASIPGPLLAKLER 238 Query: 276 EKHSAERLYTM--DGITVTVADLFFAGTE 302 + + + + + VA+L AG E Sbjct: 239 HQDDPKAVLEIGVEHAVRQVAELLEAGVE 267 >3J9E-D nrPDB Length = 526 Score = 33.5 bits (75), Expect = 0.24, Method: Composition-based stats. Identities = 21/126 (16%), Positives = 45/126 (35%), Gaps = 13/126 (10%) Query: 187 KHFDYNDEKFLRLMYLFNENFHLLS----------TPWLQLYNNFPSFLHYLPGSHRKVI 236 YND+ + E ++ ++ + L S+ L ++ Sbjct: 111 VRLKYNDKIKEKFGKELEEVYNFMNGEANAEIEDEKQFDILNKAVTSYNKILTEEDLQMR 170 Query: 237 KNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADL 296 + +++ + ER H +++ RD D L +E E+ + + I AD+ Sbjct: 171 RLATALQKEIGERT--HAETVMVKEYRDKIDALKNAIEVER-DGMQEEAIQEIAGMTADV 227 Query: 297 FFAGTE 302 A +E Sbjct: 228 LEAASE 233 >3ES8-A nrPDB Length = 391 Score = 32.8 bits (73), Expect = 0.33, Method: Composition-based stats. Identities = 27/107 (25%), Positives = 45/107 (42%), Gaps = 16/107 (14%) Query: 39 LPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFS 98 PI + F E+++ + ++ VF LYVG A +E L K+EF Sbjct: 132 YPIFRHRFSEEVESNLDVVRQKLEQGFDVFRLYVGK-------NLDADEEFLSRVKEEFG 184 Query: 99 GRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNES 145 R + ++ F++ WKD R ++ L Y +G + ES Sbjct: 185 SRVRIKSYD--------FSHLLNWKDAHR-AIKRLTKYDLGLEMIES 222 >5L9W-B nrPDB Length = 732 Score = 32.8 bits (73), Expect = 0.40, Method: Composition-based stats. Identities = 17/89 (19%), Positives = 28/89 (31%), Gaps = 4/89 (4%) Query: 247 SERVKEHHQSLDPNCPRDLT--DCLLVEMEKEKHSAE--RLYTMDGITVTVADLFFAGTE 302 +RV E N P L D +L E+ S R + + + L G Sbjct: 115 GQRVAERRNIAVQNKPLPLIERDLILGVRERIDSSGSVVRPLDEEDVRTKLRMLMDRGAR 174 Query: 303 TTSTTLRYGLLILMKYPEIEEKLHEEIDR 331 +L + + + E + EE Sbjct: 175 AIVVSLLWSFMNPAHEKRVREIIREEYKE 203 >5H80-A nrPDB Length = 494 Score = 31.6 bits (70), Expect = 0.73, Method: Composition-based stats. Identities = 17/81 (20%), Positives = 33/81 (40%), Gaps = 7/81 (8%) Query: 261 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 320 P D LL ++ + A + +++ AG ST L + L L+ +P+ Sbjct: 413 TPSPQYDALLAKVVVHRRDAALPGLLRQAATALSEFQIAGV---STNLAF-LQALLHHPD 468 Query: 321 IEEKLHEEIDRVIGPSRIPAI 341 ++ H E+ R+P + Sbjct: 469 VQ---HYELSTHWLDERLPEL 486 >6FEC-u nrPDB Length = 636 Score = 29.7 bits (65), Expect = 2.7, Method: Composition-based stats. Identities = 15/66 (22%), Positives = 23/66 (34%), Gaps = 3/66 (4%) Query: 319 PEIEEKLHE-EIDRVIGPSRIPAIKDRQEMPY--MDAVVHEIQRFITLVPSNLPHEATRD 375 P E IDR P P +PY + + E R + + LP E + Sbjct: 99 PTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPREPSNP 158 Query: 376 TIFRGY 381 +G+ Sbjct: 159 ERLKGF 164 >4DJD-D nrPDB Length = 323 Score = 29.7 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 12/47 (25%), Positives = 22/47 (46%), Gaps = 10/47 (21%) Query: 290 TVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPS 336 VT L AG ++LM++PE ++ E ID+++ + Sbjct: 285 AVTATALLQAGAH----------ILLMRHPEAVARVKENIDQLMVSN 321 >3RFT-A nrPDB Length = 267 Score = 29.3 bits (64), Expect = 3.9, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 19/55 (34%), Gaps = 11/55 (20%) Query: 391 PTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARM 445 S + +P E+ P+ +G + G C GE LARM Sbjct: 106 IVFASSNHTIGYYPQTERLGPDVPARPDGLY-----------GVSKCFGENLARM 149 >2B8N-A nrPDB Length = 429 Score = 28.5 bits (62), Expect = 6.5, Method: Composition-based stats. Identities = 18/73 (24%), Positives = 27/73 (36%), Gaps = 8/73 (10%) Query: 319 PEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYM--DAVVHEIQRFITLVPSNLPHEATRDT 376 PE +KL EI + + P ++ +P + D V+ + V A Sbjct: 16 PESLKKLAIEIVKKSIEAVFPDRAVKETLPKLNLDRVI------LVAVGKAAWRMAKAAY 69 Query: 377 IFRGYLIPKGTVV 389 G I KG VV Sbjct: 70 EVLGKKIRKGVVV 82 >3GFZ-A nrPDB Length = 413 Score = 28.1 bits (61), Expect = 8.2, Method: Composition-based stats. Identities = 17/113 (15%), Positives = 33/113 (29%), Gaps = 17/113 (15%) Query: 317 KYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDT 376 ++ ++ E + + I D + D + EI RF T Sbjct: 78 RHRDVVELMRDYSAYRRFHGTGMRILDLRLFE-TDGALEEILRFSTF------------- 123 Query: 377 IFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKP 429 G P + L + + D + PE +P ++ + P Sbjct: 124 ---GVTEPVNDRMFRLLSAFIADGGRYCLPEPLQPSRWMMMPASGTAAPQHLP 173 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.130 0.342 Lambda K H 0.267 0.0398 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,626,930 Number of Sequences: 36641 Number of extensions: 765043 Number of successful extensions: 3486 Number of sequences better than 10.0: 180 Number of HSP's better than 10.0 without gapping: 233 Number of HSP's successfully gapped in prelim test: 104 Number of HSP's that attempted gapping in prelim test: 2542 Number of HSP's gapped (non-prelim): 365 length of query: 493 length of database: 10,336,785 effective HSP length: 101 effective length of query: 392 effective length of database: 6,636,044 effective search space: 2601329248 effective search space used: 2601329248 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (20.8 bits) S2: 61 (28.1 bits)