BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P05177 (516 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2HI4-A nrPDB 1010 0.0 6DWN-A nrPDB 728 0.0 6IQ5-A nrPDB 332 3e-91 6B82-A nrPDB 275 3e-74 4R20-A nrPDB 255 3e-68 4R1Z-A nrPDB 248 3e-66 5UYS-A nrPDB 236 2e-62 3TBG-A nrPDB 222 3e-58 3E6I-A nrPDB 217 8e-57 4H1N-A nrPDB 215 3e-56 1N6B-A nrPDB 213 1e-55 2PG7-A nrPDB 211 6e-55 5W0C-A nrPDB 209 2e-54 5E0E-A nrPDB 209 3e-54 5E58-A nrPDB 202 3e-52 3DL9-A nrPDB 201 6e-52 3IBD-A nrPDB 201 7e-52 2NNH-A nrPDB 199 2e-51 4GQS-A nrPDB 193 2e-49 3QZ1-A nrPDB 177 7e-45 5VBU-A nrPDB 167 8e-42 5YLW-A nrPDB 162 3e-40 5VEU-A nrPDB 108 7e-24 6DA2-A nrPDB 101 6e-22 3K9V-A nrPDB 94 1e-19 3EL3-A nrPDB 91 9e-19 2VE3-A nrPDB 80 2e-15 3MDV-A nrPDB 80 3e-15 3JUS-A nrPDB 77 2e-14 6C94-A nrPDB 74 2e-13 6AYB-A nrPDB 72 5e-13 5JLC-A nrPDB 72 7e-13 5FSA-A nrPDB 71 1e-12 3MZS-A nrPDB 67 2e-11 3N9Z-A nrPDB 65 8e-11 6CR2-A nrPDB 64 1e-10 5M0P-A nrPDB 64 2e-10 4WMZ-A nrPDB 63 3e-10 2WX2-A nrPDB 63 4e-10 2W0A-A nrPDB 62 4e-10 3S79-A nrPDB 61 1e-09 4KPA-A nrPDB 61 1e-09 5HDI-A nrPDB 60 2e-09 3L4D-A nrPDB 58 9e-09 2Y5N-A nrPDB 58 1e-08 2ZQJ-A nrPDB 57 2e-08 3NC3-A nrPDB 55 5e-08 3TYW-A nrPDB 54 1e-07 6FYJ-A nrPDB 54 1e-07 3AWQ-A nrPDB 54 2e-07 5YSW-A nrPDB 52 7e-07 3OFT-A nrPDB 51 1e-06 6DCD-A nrPDB 51 1e-06 3SN5-A nrPDB 50 2e-06 6M7X-A nrPDB 49 4e-06 2FR7-A nrPDB 48 1e-05 4ZGX-A nrPDB 48 1e-05 2X2N-A nrPDB 47 1e-05 1CPT-A nrPDB 47 1e-05 4WPZ-A nrPDB 47 1e-05 1EHE-A nrPDB 47 2e-05 3MGX-A nrPDB 47 2e-05 5VWS-A nrPDB 46 3e-05 3P3Z-A nrPDB 46 4e-05 6G71-A nrPDB 46 5e-05 3ABA-A nrPDB 45 6e-05 5YHJ-A nrPDB 45 8e-05 4YT3-A nrPDB 44 2e-04 3TKT-A nrPDB 44 2e-04 4DO1-A nrPDB 44 2e-04 4Z5Q-A nrPDB 44 2e-04 2Z36-A nrPDB 43 3e-04 5IT1-A nrPDB 43 3e-04 4MM0-A nrPDB 43 3e-04 5Y1I-A nrPDB 43 3e-04 4GGV-A nrPDB 43 4e-04 2WIY-A nrPDB 42 6e-04 2ZBZ-A nrPDB 42 6e-04 6GMF-A nrPDB 42 8e-04 5DE9-A nrPDB 42 8e-04 3RWL-A nrPDB 42 9e-04 6HQG-A nrPDB 41 0.001 2VZM-A nrPDB 41 0.002 6A7I-A nrPDB 40 0.002 6G5O-A nrPDB 40 0.002 6A7J-A nrPDB 40 0.002 5XNT-A nrPDB 40 0.002 1WIY-A nrPDB 40 0.002 5XJN-A nrPDB 40 0.003 2RFC-A nrPDB 40 0.003 5GWE-A nrPDB 40 0.003 2WIO-A nrPDB 39 0.004 5XW2-A nrPDB 39 0.005 1Q5D-A nrPDB 39 0.005 6B11-A nrPDB 39 0.005 3A50-A nrPDB 39 0.005 6M7L-A nrPDB 39 0.005 2IAG-A nrPDB 39 0.005 6GK6-A nrPDB 39 0.007 2IJ7-A nrPDB 39 0.007 6HQW-A nrPDB 38 0.010 3B98-A nrPDB 37 0.015 6F0B-A nrPDB 37 0.016 4OQR-A nrPDB 37 0.019 5EX6-C nrPDB 37 0.020 4OQS-A nrPDB 37 0.022 1Z8P-A nrPDB 37 0.025 1LG9-A nrPDB 37 0.026 6GII-A nrPDB 36 0.035 2X9P-A nrPDB 36 0.035 5Z9I-A nrPDB 35 0.053 4YZR-A nrPDB 35 0.058 1UED-A nrPDB 35 0.059 5LIE-A nrPDB 35 0.062 5L94-A nrPDB 35 0.068 3EJB-B nrPDB 35 0.081 2NZA-A nrPDB 35 0.085 5H1Z-A nrPDB 35 0.093 1GWI-A nrPDB 35 0.099 3BUJ-A nrPDB 34 0.14 1ODO-A nrPDB 34 0.14 5D3U-A nrPDB 34 0.14 5FYF-A nrPDB 34 0.18 3A1L-A nrPDB 34 0.18 5FOI-A nrPDB 33 0.23 2QBO-A nrPDB 33 0.41 5DQN-A nrPDB 33 0.44 5OMS-A nrPDB 32 0.51 5MLC-D nrPDB 32 0.61 3IVF-A nrPDB 32 0.94 4RM4-A nrPDB 31 1.0 4TRI-A nrPDB 31 1.1 5MV8-A nrPDB 31 1.5 2KMA-A nrPDB 30 1.7 6BHV-A nrPDB 30 1.7 2QTV-A nrPDB 30 2.0 4OQA-C nrPDB 30 2.3 3DBM-A nrPDB 30 2.4 4UND-A nrPDB 30 2.6 3NV6-A nrPDB 30 2.9 6MYA-A nrPDB 30 3.6 6AH0-L nrPDB 29 4.2 6HA1-C nrPDB 29 5.6 5MYJ-BD nrPDB 29 6.0 4M9C-A nrPDB 28 7.2 >2HI4-A nrPDB Length = 495 Score = 1010 bits (2611), Expect = 0.0, Method: Compositional matrix adjust. Identities = 489/490 (99%), Positives = 489/490 (99%), Gaps = 1/490 (0%) Query: 27 VLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVL 86 VLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVL Sbjct: 3 VLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVL 62 Query: 87 VLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNT 146 VLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNT Sbjct: 63 VLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNT 122 Query: 147 FSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFG 206 FSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFG Sbjct: 123 FSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFG 182 Query: 207 QHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQK 266 QHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQK Sbjct: 183 QHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQK 242 Query: 267 TVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAI 326 TVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAI Sbjct: 243 TVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAI 302 Query: 327 SWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTI 386 SWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTI Sbjct: 303 SWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTI 362 Query: 387 PHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSE 446 PHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSE Sbjct: 363 PHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSE 422 Query: 447 KMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEH 506 KMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEH Sbjct: 423 KMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEH 482 Query: 507 VQARLRFSIN 516 VQAR RFSIN Sbjct: 483 VQAR-RFSIN 491 >6DWN-A nrPDB Length = 491 Score = 728 bits (1878), Expect = 0.0, Method: Compositional matrix adjust. Identities = 352/478 (73%), Positives = 408/478 (85%), Gaps = 3/478 (0%) Query: 37 KGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQ 96 KGLK+PP PWGWPL+GH+LTLGKNPHLALSRMSQ+YGDVLQIRIGSTPV+VLS LDTIRQ Sbjct: 8 KGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ 67 Query: 97 ALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASS 156 ALVRQGDDFKGRPDLYT TLI++GQS++FS DSGPVWAARRRLAQN L +FSIASDPASS Sbjct: 68 ALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASS 127 Query: 157 SSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEM 216 +SCYLEEHVSKEA+ LIS LQELMAGPGHF+PY VVVSV NVI A+CFG+ + + E+ Sbjct: 128 TSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQEL 187 Query: 217 LSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFD 276 LSLV + F E SGNP DF PILRYLPNP+L FK N++F F+QK V+EHY+ F+ Sbjct: 188 LSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFE 247 Query: 277 KNSVRDITGALFKHSK-KGPRASGNL-IPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLV 334 K +RDIT +L +H + K + N+ + EKI+N+V D+FGAGFDTVTTAISWSLMYLV Sbjct: 248 KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 307 Query: 335 TKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDT 394 P +QRKIQ+ELDTVIGR RRPRLSDR LPY+EAFILETFRHSSF+PFTIPHSTTRDT Sbjct: 308 MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDT 367 Query: 395 TLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMG 454 +L GFYIPK CVFVNQWQ+NHD +LW +PSEF PERFLT DG AI+K LSEK+++FGMG Sbjct: 368 SLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG-AIDKVLSEKVIIFGMG 426 Query: 455 KRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLR 512 KR+CIGE +A+WE+FLFLAILLQ++EFSVP GVKVD+TPIYGLTMKHA CEH Q +LR Sbjct: 427 KRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLR 484 >6IQ5-A nrPDB Length = 463 Score = 332 bits (850), Expect = 3e-91, Method: Compositional matrix adjust. Identities = 178/447 (39%), Positives = 255/447 (57%), Gaps = 13/447 (2%) Query: 62 HLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQ 121 HL+ +R+++RYGDV QIR+GS P++VL+ I QALV+QG F RP + +++ G+ Sbjct: 4 HLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGR 63 Query: 122 SLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMA 181 S+ F S W +RR A + + F P S LE HV EA+ L++ L A Sbjct: 64 SMAFGHYSEH-WKVQRRAAHSMMRNF-FTRQPRSRQ--VLEGHVLSEARELVALLVRGSA 119 Query: 182 GPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPI 241 DP VV+VANV+ A+CFG + E L+ + EF T +G+ +D P Sbjct: 120 DGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPW 179 Query: 242 LRYLPNPALQRFKAF---NQRFLWFLQKTVQEHYQDFDKNSV-RDITGALF----KHSKK 293 L+Y PNP F+ F N+ F F+ H + + RD+ A K + Sbjct: 180 LQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAG 239 Query: 294 GPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGR 353 G + E + + DIFGA DT++TA+ W L+ P++Q ++Q ELD V+GR Sbjct: 240 DSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGR 299 Query: 354 ERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQ 413 +R P + D+P LPY+ AF+ E R SSF+P TIPH+TT +T++ G++IPK VFVNQW Sbjct: 300 DRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWS 359 Query: 414 VNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLA 473 VNHDP W +P F P RFL DG INK L+ ++M+F +GKRRCIGE L+K ++FLF++ Sbjct: 360 VNHDPVKWPNPENFDPARFLDKDGL-INKDLTSRVMIFSVGKRRCIGEELSKMQLFLFIS 418 Query: 474 ILLQQLEFSVPPGVKVDLTPIYGLTMK 500 IL Q +F P + YGLT+K Sbjct: 419 ILAHQCDFRANPNEPAKMNFSYGLTIK 445 >6B82-A nrPDB Length = 509 Score = 275 bits (704), Expect = 3e-74, Method: Compositional matrix adjust. Identities = 154/474 (32%), Positives = 254/474 (53%), Gaps = 19/474 (4%) Query: 35 VPKGLKSPPEPWGWPLLGHVLTLGKN--PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLD 92 VP G +SPP P++G +++L + PH+ + ++YGD+ + +GS +L+++ Sbjct: 18 VPAGNRSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHH 77 Query: 93 TIRQALVRQGDDFKGRPDLYTSTLIT-DGQSLTFSTDSGPVWAARRRLAQNALNTFSIAS 151 ++ L+++G F GRP T+ L+T DG+ + F+ D W R++ AL F Sbjct: 78 HAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFA-DYSSTWKFHRKMVHGALCMFG--- 133 Query: 152 DPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPE 211 S +E+ + +EA ++ L E P ++ +V NV+ A+CF + Sbjct: 134 ----EGSVSIEKIICREASSMCEVLTESQNSAVDLGP--ELTRAVTNVVCALCFNSSYKR 187 Query: 212 SSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEH 271 E S+++ + V+T + + +D FP L+ PN L+ + LQK +EH Sbjct: 188 GDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLRILRQCISIRDKLLQKKYEEH 247 Query: 272 YQDFDKNSVRDITGALFKHSKKGPRASGNL----IPQEKIVNLVNDIFGAGFDTVTTAIS 327 + N RD+ AL + + + + + ++ ++ V +IFGAG +T TT + Sbjct: 248 KVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTTLK 307 Query: 328 WSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIP 387 WS+ YLV P++QRKIQ+ELD+ IG+ER P+LSDR LPYLEA I E R P IP Sbjct: 308 WSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIP 367 Query: 388 HSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEK 447 H +D+++ + + K V +N W ++HD + W++P F P RFL +G + P S Sbjct: 368 HVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCP-SGS 426 Query: 448 MMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKV-DLTPIYGLTMK 500 + FG G R C+GE LAK E+FLFLA +LQ+ +P G + DL +G+ ++ Sbjct: 427 YLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQ 480 >4R20-A nrPDB Length = 486 Score = 255 bits (652), Expect = 3e-68, Method: Compositional matrix adjust. Identities = 145/445 (32%), Positives = 232/445 (52%), Gaps = 16/445 (3%) Query: 61 PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG 120 PHL +++S +YG + + G LV+S + +R+ L+++G +F GRP + T+ L+T G Sbjct: 41 PHLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQG 100 Query: 121 QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM 180 D P+W RRL ++ F S+ L+ V + A +L +EL Sbjct: 101 GKDIAFADYSPLWKNHRRLVHSSFTLFGEGSN-------KLQTIVQEAADSLC---EELQ 150 Query: 181 AGPGHFDPYNQVVV-SVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFF 239 A G + V++ +V NVI + F + S E+ ++++ V+T + G +D F Sbjct: 151 ACRGQSSDLSVVLMRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIF 210 Query: 240 PILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASG 299 P LR PN L+R K L K + EH + RD+ AL ++G + Sbjct: 211 PWLRIFPNKDLKRLKECVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALLIGQQRGSGGAD 270 Query: 300 NLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRL 359 + I ++ ++ + FGAG +T +T + W++ +L+ P++Q ++Q ELD +G +R P L Sbjct: 271 D-ITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCL 329 Query: 360 SDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPE 419 SDRP LP L+A + E R P IPH +DT+L G +PK V VN W ++HDP+ Sbjct: 330 SDRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPK 389 Query: 420 LWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 W+ P +F PERFL G K + FG G R C+GE LA+ E+FLF++ LQ+ Sbjct: 390 HWDQPEQFNPERFLEPSG---KKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRF 446 Query: 480 EFSVPPGVKV-DLTPIYGLTMKHAR 503 FS P + DL +G+ ++ R Sbjct: 447 SFSCPSEASLPDLQGRFGVVLQPER 471 >4R1Z-A nrPDB Length = 439 Score = 248 bits (634), Expect = 3e-66, Method: Compositional matrix adjust. Identities = 141/427 (33%), Positives = 226/427 (52%), Gaps = 17/427 (3%) Query: 80 IGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLIT-DGQSLTFSTDSGPVWAARRR 138 +GS +L+++ ++ L+++G F GRP T+ L+T DG+ + F+ D W R+ Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFA-DYSSTWKFHRK 59 Query: 139 LAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVAN 198 + AL F S +E+ + +EA ++ L E P ++ +V N Sbjct: 60 MVHGALCMFG-------EGSVSIEKIICREASSMCEVLTESQNSAVDLGP--ELTRAVTN 110 Query: 199 VIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQ 258 V+ A+CF + E S+++ + V+T + + +D FP L+ PN L + Sbjct: 111 VVCALCFNSSYKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLTILRQCIS 170 Query: 259 RFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNL----IPQEKIVNLVNDI 314 LQK +EH + N RD+ AL + + + + + ++ ++ V DI Sbjct: 171 IRDKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDI 230 Query: 315 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILE 374 FGAG +T TT + WS+ YLV P++QRKIQ+ELD+ IG+ER P+LSDR LPYLEA I E Sbjct: 231 FGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIRE 290 Query: 375 TFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434 R P IPH +D+++ + + K V +N W ++HD + W++P F P RFL Sbjct: 291 VLRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLN 350 Query: 435 ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKV-DLTP 493 +G + P S + FG G R C+GE LAK E+FLFLA +LQ+ +P G + DL Sbjct: 351 EEGDGLCCP-SGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQG 409 Query: 494 IYGLTMK 500 +G+ ++ Sbjct: 410 KFGVVLQ 416 >5UYS-A nrPDB Length = 494 Score = 236 bits (602), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 138/458 (30%), Positives = 240/458 (52%), Gaps = 24/458 (5%) Query: 38 GLKSPPEPWGWPLLGHVLTLGKNPHLALS--RMSQRYGDVLQIRIGSTPVLVLSRLDTIR 95 G K P PL+G + L ++ H+ + ++ ++YG + +R+G+ +++ + Sbjct: 6 GAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAK 65 Query: 96 QALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPAS 155 + L+++G DF GRP + T + ++ + DSG W RRLA + TF++ D Sbjct: 66 EVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLA---MATFALFKD--- 119 Query: 156 SSSCYLEEHVSKEAKALISRLQELMAGPG--HFDPYNQVVVSVANVIGAMCFGQHFPESS 213 LE+ + +E IS L +++A D V V+V NVI +CF + ++ Sbjct: 120 -GDQKLEKIICQE----ISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSY-KNG 173 Query: 214 DEMLSLVKNTHE-FVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHY 272 D L++++N +E ++ S + +D P L+ PN L++ K+ + L K ++ + Sbjct: 174 DPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYK 233 Query: 273 QDFDKNSVRDITGALFK------HSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAI 326 + F +S+ ++ L + + GP L+ I+ + DIFGAG +T T+ + Sbjct: 234 EKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVV 293 Query: 327 SWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTI 386 W+L +L+ P++++K+ +E+D +G R P +SDR +L LEA I E R P I Sbjct: 294 KWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLI 353 Query: 387 PHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSE 446 PH D+++ F + K V +N W ++H+ + W P +F PERFL GT + P S Sbjct: 354 PHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISP-SV 412 Query: 447 KMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVP 484 + FG G R CIGE+LA+ E+FL +A LLQ+ + VP Sbjct: 413 SYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 450 >3TBG-A nrPDB Length = 479 Score = 222 bits (566), Expect = 3e-58, Method: Compositional matrix adjust. Identities = 141/436 (32%), Positives = 220/436 (50%), Gaps = 24/436 (5%) Query: 59 KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLIT 118 +N ++ +R+GDV +++ TPV+VL+ L +R+ALV G+D RP + + ++ Sbjct: 30 QNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILG 89 Query: 119 DG--QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRL 176 G F GP W +RR + + L + LE+ V++EA L + Sbjct: 90 FGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKK-------SLEQWVTEEAACLCAAF 142 Query: 177 QELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASS--GN 234 P F P + +V+NVI ++ G+ F L L+ E ++ S Sbjct: 143 ANHSGRP--FRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLRE 200 Query: 235 PLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFD-KNSVRDITGALF---KH 290 L+ P+L ++P A + + F + FL L + + EH +D RD+T A + Sbjct: 201 VLNAVPVLLHIPALAGKVLR-FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEK 259 Query: 291 SKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTV 350 +K P +S N E + +V D+F AG T +T ++W L+ ++ P++QR++Q+E+D V Sbjct: 260 AKGNPESSFN---DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDV 316 Query: 351 IGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVN 410 IG+ RRP + D+ +PY A I E R +P + H T+RD + GF IPK + N Sbjct: 317 IGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITN 376 Query: 411 QWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFL 470 V D +WE P F PE FL A G + KP E + F G+R C+GE LA+ E+FL Sbjct: 377 LSSVLKDEAVWEKPFRFHPEHFLDAQGHFV-KP--EAFLPFSAGRRACLGEPLARMELFL 433 Query: 471 FLAILLQQLEFSVPPG 486 F LLQ FSVP G Sbjct: 434 FFTSLLQHFSFSVPTG 449 >3E6I-A nrPDB Length = 476 Score = 217 bits (553), Expect = 8e-57, Method: Compositional matrix adjust. Identities = 144/463 (31%), Positives = 235/463 (50%), Gaps = 25/463 (5%) Query: 40 KSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 K PP P+ P++G++ L KN + +R++QR+G V + +GS ++V+ +++AL Sbjct: 10 KLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEAL 69 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 + D+F GR DL D + + F ++GP W RR + L + + S Sbjct: 70 LDYKDEFSGRGDLPAFHAHRD-RGIIF--NNGPTWKDIRRFSLTTLRNYGMGKQGNESR- 125 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218 + +EA L+ L++ P FDP + + NVI + F +HF + ++ L Sbjct: 126 ------IQREAHFLLEALRKTQGQP--FDPTFLIGCAPCNVIADILFRKHFDYNDEKFLR 177 Query: 219 LVKNTHEFVETASSG--NPLDFFP-ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF 275 L+ +E S+ + FP L YLP + K + ++ + V+EH+Q Sbjct: 178 LMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAE-VKEYVSERVKEHHQSL 236 Query: 276 DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 335 D N RD+T L +K ++ L + I V D+F AG +T +T + + L+ L+ Sbjct: 237 DPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMK 296 Query: 336 KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTT 395 PEI+ K+ +E+D VIG R P + DR ++PY++A + E R + +P +PH TRDT Sbjct: 297 YPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTI 356 Query: 396 LNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK 455 G+ IPK V V +D + + DP +F+PE FL +G S+ F GK Sbjct: 357 FRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKF---KYSDYFKPFSTGK 413 Query: 456 RRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV---KVDLTPIY 495 R C GE LA+ E+FL L +LQ F++ P V +DL+PI+ Sbjct: 414 RVCAGEGLARMELFLLLCAILQH--FNLKPLVDPKDIDLSPIH 454 >4H1N-A nrPDB Length = 479 Score = 215 bits (548), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 140/460 (30%), Positives = 229/460 (49%), Gaps = 22/460 (4%) Query: 40 KSPPEPWGWPLLGHVLTLGKNPHL-ALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 K PP P P+LG++L + + L + R+ ++YGDV + +GS PV+VL D IR+AL Sbjct: 10 KLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLCGTDAIREAL 69 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 V Q + F GR + I G + F+ +G W A RR + + F + Sbjct: 70 VDQAEAFSGRGKIAVVDPIFQGYGVIFA--NGERWRALRRFSLATMRDFGMGKRS----- 122 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSV-ANVIGAMCFGQHFPESSDEML 217 +EE + +EA+ L+ +EL G + S+ +N+I ++ FG+ F L Sbjct: 123 --VEERIQEEARCLV---EELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFL 177 Query: 218 SLVK--NTHEFVETASSGNPLDFFP-ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQD 274 L+ + ++ S + F L+Y P Q ++ Q F+ ++V++H Sbjct: 178 RLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNL-QEINTFIGQSVEKHRAT 236 Query: 275 FDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLV 334 D ++ RD +K + + ++ V +F AG +T +T + + + ++ Sbjct: 237 LDPSNPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLML 296 Query: 335 TKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDT 394 P + ++QKE++ VIG R P L DR ++PY +A I E R +PF +PH+ T+DT Sbjct: 297 KYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDT 356 Query: 395 TLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMG 454 G+ IPK VF HDP +E P+ F P FL A+G A+ + +E M F +G Sbjct: 357 QFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANG-ALKR--NEGFMPFSLG 413 Query: 455 KRRCIGEVLAKWEIFLFLAILLQQLEFSVP-PGVKVDLTP 493 KR C+GE +A+ E+FLF +LQ + P P +DLTP Sbjct: 414 KRICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTP 453 >1N6B-A nrPDB Length = 473 Score = 213 bits (543), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 145/482 (30%), Positives = 238/482 (49%), Gaps = 47/482 (9%) Query: 40 KSPPEPWGWPLLGHVLTL-GKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 K PP P +P++G++L + K+ +L++ S+ YG V + +G P +VL + +++AL Sbjct: 10 KLPPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLHGYEAVKEAL 69 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 V G++F GR + ++ G + FS + W RR + L F + Sbjct: 70 VDLGEEFAGRGSVPILEKVSKGLGIAFS--NAKTWKEMRRFSLMTLRNFGMGKRS----- 122 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218 +E+ + +EA+ L+ L++ A P DP + + NVI ++ F F +E L Sbjct: 123 --IEDRIQEEARCLVEELRKTNASPC--DPTFILGCAPCNVICSVIFHNRFDYKDEEFLK 178 Query: 219 LVKNTHEFVETASSGNP----LDFFP-ILRYLPNPALQRFKAFNQRFLW-FLQKTVQEHY 272 L+++ HE VE G P + FP +L Y P + + N ++ F+ + V+EH Sbjct: 179 LMESLHENVELL--GTPWLQVYNNFPALLDYFP--GIHKTLLKNADYIKNFIMEKVKEHQ 234 Query: 273 QDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332 + D N+ RD ++ L E +V V+D+FGAG +T +T + +SL+ Sbjct: 235 KLLDVNNPRDFIDCFLIKMEQENNLEFTL---ESLVIAVSDLFGAGTETTSTTLRYSLLL 291 Query: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392 L+ PE+ ++Q+E++ VIGR R P + DR ++PY +A I E R LP +PH+ TR Sbjct: 292 LLKHPEVAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTR 351 Query: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFG 452 D ++IPK + + V HD + + +P F P FL G N S+ M F Sbjct: 352 DVRFRNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESG---NFKKSDYFMPFS 408 Query: 453 MGKRRCIGEVLAKWEIFLFLAILLQQLEF-------------------SVPPGVKVDLTP 493 GKR C+GE LA+ E+FLFL +LQ + SVPP ++ P Sbjct: 409 AGKRMCVGEGLARMELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPSYQLCFIP 468 Query: 494 IY 495 I+ Sbjct: 469 IH 470 >2PG7-A nrPDB Length = 476 Score = 211 bits (537), Expect = 6e-55, Method: Compositional matrix adjust. Identities = 135/459 (29%), Positives = 224/459 (48%), Gaps = 20/459 (4%) Query: 40 KSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 K PP P P +G+ L L + + +L ++S+RYG V I +G V+VL D +R+AL Sbjct: 10 KLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREAL 69 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 V Q ++F GR + T + G + FS +G RR + L F + Sbjct: 70 VDQAEEFSGRGEQATFDWVFKGYGVVFS--NGERAKQLRRFSIATLRDFGVGKRG----- 122 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218 +EE + +EA LI L+ G + DP + +V+NVI ++ FG F E LS Sbjct: 123 --IEERIQEEAGFLIDALRG--TGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLS 178 Query: 219 LVK---NTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF 275 L++ +F T++ F ++++LP P Q F+ Q F+ K V+ + + Sbjct: 179 LLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLL-QGLEDFIAKKVEHNQRTL 237 Query: 276 DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 335 D NS RD + ++ + + +V +F G +TV+T + + + L+ Sbjct: 238 DPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMK 297 Query: 336 KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTT 395 PE++ K+ +E+D VIG+ R+P+ DR ++PY+EA I E R +P ++ +DT Sbjct: 298 HPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTK 357 Query: 396 LNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK 455 F++PK V+ V DP + +P +F P+ FL G S+ + F +GK Sbjct: 358 FRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKK---SDAFVPFSIGK 414 Query: 456 RRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVK-VDLTP 493 R C GE LA+ E+FLF ++Q K +D++P Sbjct: 415 RNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSP 453 >5W0C-A nrPDB Length = 477 Score = 209 bits (533), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 139/462 (30%), Positives = 230/462 (49%), Gaps = 24/462 (5%) Query: 40 KSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 K PP P P++G++L +G K+ +L+ +S+ YG V + G P++VL + +++AL Sbjct: 11 KLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEAL 70 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 + G++F GR + G + FS +G W RR + L F + Sbjct: 71 IDLGEEFSGRGIFPLAERANRGFGIVFS--NGKKWKEIRRFSLMTLRNFGMGKRS----- 123 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218 +E+ V +EA+ L+ L++ A P DP + + NVI ++ F + F + L+ Sbjct: 124 --IEDRVQEEARCLVEELRKTKASPC--DPTFILGCAPCNVICSIIFHKRFDYKDQQFLN 179 Query: 219 LVKNTHEFVETASS-----GNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQ 273 L++ +E ++ SS N +F PI+ Y P + K + L+K V+EH + Sbjct: 180 LMEKLNENIKILSSPWIQICN--NFSPIIDYFPGTHNKLLKNVAFMKSYILEK-VKEHQE 236 Query: 274 DFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYL 333 D N+ +D +K + E + N D+FGAG +T +T + ++L+ L Sbjct: 237 SMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLL 296 Query: 334 VTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRD 393 + PE+ K+Q+E++ VIGR R P + DR +PY +A + E R+ LP ++PH+ T D Sbjct: 297 LKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCD 356 Query: 394 TTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGM 453 + IPK + ++ V HD + + +P F P FL G N S+ M F Sbjct: 357 IKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGG---NFKKSKYFMPFSA 413 Query: 454 GKRRCIGEVLAKWEIFLFLAILLQQLEF-SVPPGVKVDLTPI 494 GKR C+GE LA E+FLFL +LQ S+ +D TP+ Sbjct: 414 GKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPV 455 >5E0E-A nrPDB Length = 463 Score = 209 bits (531), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 133/434 (30%), Positives = 211/434 (48%), Gaps = 19/434 (4%) Query: 64 ALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSL 123 + R+ ++YGDV + +G PV++L + IR+ALV Q + F GR + I G + Sbjct: 26 SFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTIAVVEPIFRGYGV 85 Query: 124 TFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGP 183 F+ +G W A RR + + F + +EE + +EA+ L+ ++ P Sbjct: 86 VFA--NGERWKALRRFSLVTMRDFGMGKRS-------VEERIQEEARCLVEEFRKSQGAP 136 Query: 184 GHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSG--NPLDFFP- 240 DP AN+I ++ FG+ F + L L+ ++ SS + F Sbjct: 137 --LDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFSG 194 Query: 241 ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN 300 L+Y P Q + Q L ++ ++V++H D + RD +K Sbjct: 195 FLKYFPGTHRQISRNL-QEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSNQHT 253 Query: 301 LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS 360 + +V V +F AG +T +T + + + ++ P + K+QKE+D VIG R P L Sbjct: 254 EFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLE 313 Query: 361 DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL 420 DR ++PY EA I E R S +P +PH T+DT G+ +PK V+ HDP+ Sbjct: 314 DRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 373 Query: 421 WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480 +E P F P+ FL A+G A+ K SE M F +GKR C+GE +A+ E+FLF +LQ Sbjct: 374 FEQPDTFNPDHFLDANG-ALKK--SEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFS 430 Query: 481 FSVPPGVK-VDLTP 493 S P K +DL+P Sbjct: 431 LSSPVAPKDIDLSP 444 >5E58-A nrPDB Length = 493 Score = 202 bits (514), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 132/437 (30%), Positives = 216/437 (49%), Gaps = 25/437 (5%) Query: 64 ALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSL 123 + R+ ++YGDV + +G PV++L + IR+ALV Q + F GR + + + Sbjct: 54 SFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTIAVIKPVIGDYGM 113 Query: 124 TFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGP 183 FS +G W RR + + F + +E+ + +EA+ L+ LQ+ P Sbjct: 114 IFS--NGERWKVLRRFSLATMRDFGMGKRS-------VEDRIQEEAQCLVEELQKSQGAP 164 Query: 184 GHFDPYNQVVVSVANVIGAMCFGQHFPESSDE---MLSLVKNTHEFVETASSGNPLDFFP 240 DP AN+I ++ FG+ + + +L L T + + SS F Sbjct: 165 --LDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFSG 222 Query: 241 ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRD-ITGALFKHSKKGPRASG 299 ++Y P Q + Q L ++ ++V++H D ++ RD I L + K+ Sbjct: 223 FMKYFPGAHRQITRNL-QEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSNQHT 281 Query: 300 NLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRL 359 Q ++++++ +F AG +T +T + + + ++ P + K+QKE+D VIG R P L Sbjct: 282 EFHHQNLLISVLS-LFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTL 340 Query: 360 SDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPE 419 DR ++PY +A I E R S P PH T+DT G+ +PK V+ HDP+ Sbjct: 341 EDRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQ 400 Query: 420 LWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 +E P F P+ FL A+G A+ K SE M F +GKR C+GE +A+ E+FLF +LQ Sbjct: 401 YFEQPGTFNPDHFLDANG-ALKK--SEAFMPFSIGKRICLGEGIARNELFLFFTTILQN- 456 Query: 480 EFSVPPGV---KVDLTP 493 FSV V +DL+P Sbjct: 457 -FSVSSSVAPKDIDLSP 472 >3DL9-A nrPDB Length = 479 Score = 201 bits (511), Expect = 6e-52, Method: Compositional matrix adjust. Identities = 121/442 (27%), Positives = 209/442 (47%), Gaps = 15/442 (3%) Query: 61 PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG 120 PH+ + + SQ YG++ + +G +VL+ D +++ LV Q + F RP L +T Sbjct: 36 PHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM 95 Query: 121 QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM 180 L ++ G W RRLA N+ F E + +E K ++ Sbjct: 96 GGL-LNSRYGRGWVDHRRLAVNSFRYFGYGQKS-------FESKILEETKFFNDAIETYK 147 Query: 181 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDF-- 238 P FD + +V+N+ + FG+ F + +++ E VE A+S + + Sbjct: 148 GRP--FDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNA 205 Query: 239 FPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRAS 298 FP + LP Q+ FL + +++ + + A +G Sbjct: 206 FPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDP 265 Query: 299 GNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPR 358 + +E ++ V ++ AG +T T + W+++++ P IQ ++QKE+D ++G +P Sbjct: 266 SSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS 325 Query: 359 LSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDP 418 D+ ++PY EA + E R + +P I H+T+ D + G+ IPK V N + V+ D Sbjct: 326 WDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDE 385 Query: 419 ELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQ 478 + W DP F PERFL + G K E ++ F +G+R C+GE LA+ E+FLF LLQ+ Sbjct: 386 KYWRDPEVFHPERFLDSSGYFAKK---EALVPFSLGRRHCLGEHLARMEMFLFFTALLQR 442 Query: 479 LEFSVPPGVKVDLTPIYGLTMK 500 P + DL P G+T++ Sbjct: 443 FHLHFPHELVPDLKPRLGMTLQ 464 >3IBD-A nrPDB Length = 476 Score = 201 bits (511), Expect = 7e-52, Method: Compositional matrix adjust. Identities = 125/431 (29%), Positives = 212/431 (49%), Gaps = 19/431 (4%) Query: 67 RMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFS 126 R ++YGDV + +G PV++L ++ IR+ALV + + F GR + G + F+ Sbjct: 38 RFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFA 97 Query: 127 TDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHF 186 +G W RR + + F + +EE + +EA+ LI L++ + Sbjct: 98 --NGNRWKVLRRFSVTTMRDFGMGKRS-------VEERIQEEAQCLIEELRK--SKGALM 146 Query: 187 DPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASS--GNPLDFFP-ILR 243 DP AN+I ++ FG+ F E L ++ ++ SS G + F L+ Sbjct: 147 DPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLK 206 Query: 244 YLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIP 303 + P Q +K Q ++ +V++H + D ++ RD+ H +K + + Sbjct: 207 HFPGAHRQVYKNL-QEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSNAHSEFS 265 Query: 304 QEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRP 363 + + +F AG +T +T + + + ++ P + ++ +E++ VIG R P L DR Sbjct: 266 HQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRA 325 Query: 364 QLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWED 423 ++PY EA I E R S LP +PH T+ T+ G+ IPK VF+ HDP +E Sbjct: 326 KMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEK 385 Query: 424 PSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSV 483 P F P+ FL A+G A+ K +E + F +GKR C+GE +A+ E+FLF +LQ + Sbjct: 386 PDAFNPDHFLDANG-ALKK--TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMAS 442 Query: 484 PPGVK-VDLTP 493 P + +DLTP Sbjct: 443 PVAPEDIDLTP 453 >2NNH-A nrPDB Length = 476 Score = 199 bits (506), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 137/457 (29%), Positives = 220/457 (48%), Gaps = 41/457 (8%) Query: 40 KSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 K PP P P++G++L + K+ + + S+ YG V + G P++V + +++AL Sbjct: 10 KLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEAL 69 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 + G++F GR + S IT G L + +G W RR + L F + Sbjct: 70 IDNGEEFSGRGNSPISQRITKG--LGIISSNGKRWKEIRRFSLTTLRNFGMGKRS----- 122 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218 +E+ V +EA L+ L++ A P DP + + NVI ++ F + F L+ Sbjct: 123 --IEDRVQEEAHCLVEELRKTKASPC--DPTFILGCAPCNVICSVVFQKRFDYKDQNFLT 178 Query: 219 LVKNTHEFVETASSG--NPLDFFPIL---------RYLPNPALQRFKAFNQRFLWFLQKT 267 L+K +E +S + FP+L + L N AL R ++++ Sbjct: 179 LMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTR---------SYIREK 229 Query: 268 VQEHYQDFDKNSVRDITGALF---KHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTT 324 V+EH D N+ RD + K ++ N+ E +V V D+F AG +T +T Sbjct: 230 VKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNI---ENLVGTVADLFVAGTETTST 286 Query: 325 AISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPF 384 + + L+ L+ PE+ K+Q+E+D VIGR R P + DR +PY +A + E R+S +P Sbjct: 287 TLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPT 346 Query: 385 TIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPL 444 +PH+ T DT + IPK + V HD + + +P+ F P FL +G N Sbjct: 347 GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNG---NFKK 403 Query: 445 SEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEF 481 S+ M F GKR C GE LA+ E+FLFL +LQ Sbjct: 404 SDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNL 440 >4GQS-A nrPDB Length = 477 Score = 193 bits (490), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 133/460 (28%), Positives = 224/460 (48%), Gaps = 20/460 (4%) Query: 40 KSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 K PP P P++G++L + K+ +L+ +S+ YG V + G ++VL + +++AL Sbjct: 11 KLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEAL 70 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 + G++F GR + G + FS +G W RR + L F + Sbjct: 71 IDLGEEFSGRGHFPLAERANRGFGIVFS--NGKRWKEIRRFSLMTLRNFGMGKRS----- 123 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218 +E+ V +EA+ L+ L++ A P DP + + NVI ++ F + F + L+ Sbjct: 124 --IEDRVQEEARCLVEELRKTKASPC--DPTFILGCAPCNVICSIIFQKRFDYKDQQFLN 179 Query: 219 LVKNTHEFVETASSG--NPLDFFP-ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF 275 L++ +E + S+ + FP I+ Y P + K L+K V+EH + Sbjct: 180 LMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK-VKEHQESM 238 Query: 276 DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 335 D N+ RD +K + + E +V D+ GAG +T +T + ++L+ L+ Sbjct: 239 DINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLK 298 Query: 336 KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTT 395 PE+ K+Q+E++ V+GR R P + DR +PY +A + E R+ +P ++PH+ T D Sbjct: 299 HPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVK 358 Query: 396 LNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK 455 + IPK + + V HD + + +P F P FL G N S M F GK Sbjct: 359 FRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGG---NFKKSNYFMPFSAGK 415 Query: 456 RRCIGEVLAKWEIFLFLAILLQQLEF-SVPPGVKVDLTPI 494 R C+GE LA+ E+FLFL +LQ S+ +D TP+ Sbjct: 416 RICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPV 455 >3QZ1-A nrPDB Length = 496 Score = 177 bits (450), Expect = 7e-45, Method: Compositional matrix adjust. Identities = 129/448 (28%), Positives = 214/448 (47%), Gaps = 43/448 (9%) Query: 52 GHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDL 111 G + L N + L ++Q+ G V ++R+G V+VL+ TI +A++R+ DF GRP + Sbjct: 36 GFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAGRPQI 95 Query: 112 YTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKA 171 + L++ D +W A ++L ++AL + +S +E V + + Sbjct: 96 PSYKLVSQRCQDISLGDYSLLWKAHKKLTRSALLLGTRSS---------MEPWVDQLTQE 146 Query: 172 LISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETAS 231 R++ P + + ++I + FG ++ +LV H+ V+ Sbjct: 147 FCERMRVQAGAPVTIQ--KEFSLLTCSIICYLTFG-------NKEDTLVHAFHDCVQDLM 197 Query: 232 ------SGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITG 285 S LD P LR+ PNP L R K + ++K ++ H + RD+T Sbjct: 198 KTWDHWSIQILDMVPFLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTD 257 Query: 286 ALFK-----HSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQ 340 + + ++GP G L+ +++V D+F G +T + +SW++ +L+ PEIQ Sbjct: 258 YMLQGVGRQRVEEGP---GQLLEGHVHMSVV-DLFIGGTETTASTLSWAVAFLLHHPEIQ 313 Query: 341 RKIQKELDTVIG---RERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLN 397 R++Q+ELD +G R DR +LP L A I E R +P +PH TTR +++ Sbjct: 314 RRLQEELDRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIF 373 Query: 398 GFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRR 457 G+ IP+ V N + D +WE P EFRP+RFL + + FG G R Sbjct: 374 GYDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGA-------NPSALAFGCGARV 426 Query: 458 CIGEVLAKWEIFLFLAILLQQLEFSVPP 485 C+GE LA+ E+F+ LA LLQ PP Sbjct: 427 CLGESLARLELFVVLARLLQAFTLLPPP 454 >5VBU-A nrPDB Length = 476 Score = 167 bits (424), Expect = 8e-42, Method: Compositional matrix adjust. Identities = 113/416 (27%), Positives = 202/416 (48%), Gaps = 25/416 (6%) Query: 68 MSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFST 127 ++Q++G + ++ +G V+VL+ TI +A+V++ DF GRP+ T L++ Sbjct: 33 LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLG 92 Query: 128 DSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFD 187 D +W A ++L ++AL I +E V + + R++ P + Sbjct: 93 DYSLLWKAHKKLTRSAL-LLGIRDS--------MEPVVEQLTQEFCERMRAQPGTPVAIE 143 Query: 188 PYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETAS--SGNPLDFFPILRYL 245 + + ++I + FG + + M + K E ++T S S +D P LR+ Sbjct: 144 --EEFSLLTCSIICYLTFGDKI-KDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFF 200 Query: 246 PNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQE 305 PNP L+R K ++ ++ +++H + RD+ + + + G+ E Sbjct: 201 PNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLE 260 Query: 306 KIVNLVN-DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG---RERRPRLSD 361 V++ D+ G +T +SW++++L+ PEIQ+++Q+ELD +G R D Sbjct: 261 GHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKD 320 Query: 362 RPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELW 421 R +LP L A I E R +P +PH TTR ++++G+ IP+ + N + D +W Sbjct: 321 RARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVW 380 Query: 422 EDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ 477 E P EF P+RFL + + + FG G R C+GE LA+ E+F+ L LLQ Sbjct: 381 ERPHEFWPDRFLEPGKNS-------RALAFGCGARVCLGEPLARLELFVVLTRLLQ 429 >5YLW-A nrPDB Length = 495 Score = 162 bits (410), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 126/481 (26%), Positives = 211/481 (43%), Gaps = 24/481 (4%) Query: 6 SVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLAL 65 S P A +A+ I L F + L PP P+ +P++G++L LG NPH Sbjct: 3 SFPLLAALFFIAATITFLSFRRRRNL----------PPGPFPYPIVGNMLQLGANPHQVF 52 Query: 66 SRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTF 125 +++S+RYG ++ I +GS +++S + ++ L R G F GR + + D ++ Sbjct: 53 AKLSKRYGPLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGR-TIAQAVHACDHDKISM 111 Query: 126 S-TDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPG 184 W R++ + + FS S AS ++ + L+ +Q+ Sbjct: 112 GFLPVASEWRDMRKICKEQM--FSNQSMEASQGLR------RQKLQQLLDHVQKCSDSGR 163 Query: 185 HFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVET-ASSGNPLDFFPILR 243 D ++ N++ A F E + K E V T N D+FPILR Sbjct: 164 AVDIREAAFITTLNLMSATLFSSQATEFDSKATMEFKEIIEGVATIVGVPNFADYFPILR 223 Query: 244 -YLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLI 302 + P +R F + L ++ + E + N + +A+ + Sbjct: 224 PFDPQGVKRRADVFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQANEFKL 283 Query: 303 PQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDR 362 +L+ D+F G DT TT+I W++ LV P+ +++ EL +V G E+ S Sbjct: 284 KTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDESAM 343 Query: 363 PQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWE 422 P+LPYL+A I E R P +P D +NG+ IPK + +N + + DP +W Sbjct: 344 PKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSIWT 403 Query: 423 DPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482 DP F PERFL D K +++ FG G+R C G LA + + A L+ ++ Sbjct: 404 DPETFDPERFL--DNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNFDWK 461 Query: 483 V 483 + Sbjct: 462 L 462 >5VEU-A nrPDB Length = 480 Score = 108 bits (269), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 115/460 (25%), Positives = 198/460 (43%), Gaps = 55/460 (11%) Query: 43 PEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQG 102 P P PLLG+VL+ + + ++YG + G PVL ++ D IR LV++ Sbjct: 18 PGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE- 76 Query: 103 DDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPA-----SSS 157 ++ T+ +SL GPV + + S+A D S Sbjct: 77 ----------CYSVFTNRRSL------GPVGFMK--------SAISLAEDEEWKRIRSLL 112 Query: 158 SCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGA--------MCFGQHF 209 S KE +I++ +++ + V++ ++ GA FG + Sbjct: 113 SPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNI 172 Query: 210 PESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKA--FNQRFLWFLQKT 267 ++ V++T +F++ +PL IL P + F + + FL K+ Sbjct: 173 DSLNNPQDPFVESTKKFLKFGFL-DPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKS 231 Query: 268 V----QEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVT 323 V + D K+ + + + + K + L E + IF AG++T + Sbjct: 232 VNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIF-AGYETTS 290 Query: 324 TAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLP 383 + +S++L L T P++Q+K+QKE+D V+ + P Q+ YL+ + ET R P Sbjct: 291 SVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR---LFP 347 Query: 384 FTI--PHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAIN 441 I + +D +NG +IPK V + + ++HDP+ W +P EFRPERF + +I+ Sbjct: 348 VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SKKKDSID 406 Query: 442 KPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEF 481 + FG G R CIG A + L L +LQ F Sbjct: 407 PYIYTP---FGTGPRNCIGMRFALMNMKLALIRVLQNFSF 443 >6DA2-A nrPDB Length = 487 Score = 101 bits (252), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 109/459 (23%), Positives = 188/459 (40%), Gaps = 52/459 (11%) Query: 43 PEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQG 102 P P P LG++L+ K + ++YG V G PVL ++ D I+ LV++ Sbjct: 19 PGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE- 77 Query: 103 DDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPA-----SSS 157 ++ T+ + GPV + + SIA D S Sbjct: 78 ----------CYSVFTNRRPF------GPVGFMK--------SAISIAEDEEWKRLRSLL 113 Query: 158 SCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEML 217 S KE +I++ +++ + V++ +V GA S + Sbjct: 114 SPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNI 173 Query: 218 SLVKNTHE-FVETASSGNPLDF----------FPILRYLPNPALQRFKAFNQRFLWFLQK 266 + N + FVE DF FP L +P + F + FL+K Sbjct: 174 DSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFL--IPILEVLNICVFPREVTNFLRK 231 Query: 267 TV----QEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 322 +V + +D K+ V + + + K + L E + + IF AG++T Sbjct: 232 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIF-AGYETT 290 Query: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 382 ++ +S+ + L T P++Q+K+Q+E+D V+ + P Q+ YL+ + ET R + Sbjct: 291 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP-I 349 Query: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442 + +D +NG +IPK V + + ++ DP+ W +P +F PERF + I+ Sbjct: 350 AMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP 409 Query: 443 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEF 481 + FG G R CIG A + L L +LQ F Sbjct: 410 YIYTP---FGSGPRNCIGMRFALMNMKLALIRVLQNFSF 445 >3K9V-A nrPDB Length = 482 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 106/470 (22%), Positives = 197/470 (41%), Gaps = 54/470 (11%) Query: 43 PEPWGWPLLGHVLTLG-----KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQA 97 P P WPLLG +L + K H L+ ++YG + ++++GS + L ++ +A Sbjct: 27 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGS-PSLLEA 85 Query: 98 LVRQGDDFKGRPDLYTSTLITDGQSLTFSTD--SGPVWAARRRLAQNALNTFSIASDPAS 155 L R R ++ D ++ + G W R Q L P Sbjct: 86 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKL------MKPVE 139 Query: 156 SSSCYLEEHVSKEAKALISRLQELMAGPGHF-DPYNQV----VVSVANVIGAMCFGQHFP 210 L++ +++ + R+ EL G D Y+++ S+ V+ FG Sbjct: 140 IMK--LDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQK 197 Query: 211 ESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQE 270 E+ +E L+ + + T F + P +R K Q Sbjct: 198 ETEEEALTFITAIKTMMST---------FGKMMVTPVELHKRLNT----------KVWQA 238 Query: 271 HYQDFDK--NSVRDITGALFKHSKKGPRAS-------GNLIPQEKIVNLVNDIFGAGFDT 321 H +D SV+ + + P A + + ++++ V ++ A +T Sbjct: 239 HTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVET 298 Query: 322 VTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSF 381 ++ W L L P+ QR++ +E+ +V+ + PR D +PYL+A + E+ R + Sbjct: 299 TANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPS 358 Query: 382 LPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAIN 441 +PFT + + T L + +PK + +N + + +ED +FRPER+L + IN Sbjct: 359 VPFTT-RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKE-KKIN 416 Query: 442 KPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDL 491 P + + FG+GKR CIG LA+ ++ L L ++Q+ + V++ Sbjct: 417 -PFAH--LPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEM 463 >3EL3-A nrPDB Length = 467 Score = 91.3 bits (225), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 112/452 (24%), Positives = 188/452 (41%), Gaps = 35/452 (7%) Query: 33 PRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLD 92 P P+ + P G PLLGH L ++P LA + +GDV++I++G V ++ + Sbjct: 16 PGAPELREPPVAGGGVPLLGHGWRLARDP-LAFMSQLRDHGDVVRIKLGPKTVYAVTNPE 74 Query: 93 TIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASD 152 + AL D P L+ S G+ +T +GP+ +RR Q A F + + Sbjct: 75 -LTGALALNPDYHIAGP-LWESLEGLLGKE-GVATANGPLHRRQRRTIQPA---FRLDAI 128 Query: 153 PASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCF--GQHFP 210 PA +EE EA AL R Q PG VA + A C GQ+ Sbjct: 129 PAYGP--IMEE----EAHALTERWQ-----PGKTVDATSESFRVAVRVAARCLLRGQYMD 177 Query: 211 ESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQE 270 E ++ + + + + P+ R LP PA +RF + + + E Sbjct: 178 ERAERLCVALATVFRGMYRRMV---VPLGPLYR-LPLPANRRFNDALADLHLLVDEIIAE 233 Query: 271 HYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSL 330 K D+ AL + +G+ I +++I + V I G +T+ + I W L Sbjct: 234 RRASGQKPD--DLLTALLEAKDD----NGDPIGEQEIHDQVVAILTPGSETIASTIMWLL 287 Query: 331 MYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHST 390 L PE +I+ E++ V G R D +L + I+E R + + + Sbjct: 288 QALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAV-WVLTRRA 345 Query: 391 TRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMML 450 ++ L G+ IP + + + + DP+ ++D EF P+R+L + K M Sbjct: 346 VAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPK---YAMKP 402 Query: 451 FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482 F GKR+C + + ++ L A L + F Sbjct: 403 FSAGKRKCPSDHFSMAQLTLITAALATKYRFE 434 >2VE3-A nrPDB Length = 444 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 107/461 (23%), Positives = 186/461 (40%), Gaps = 53/461 (11%) Query: 39 LKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 L PP +G P LG L + R Q++G + + R+ V+ +S R Sbjct: 11 LPIPPGDFGLPWLGETLNFLNDGDFGKKR-QQQFGPIFKTRLFGKNVIFISGALANRFLF 69 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 ++ + F+ L T L+ +T G + +RR++ A ++ S Sbjct: 70 TKEQETFQATWPLSTRILLGPN---ALATQMGEIHRSRRKILYQAFLPRTLDS------- 119 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218 YL + ++ E Y Q+ +V + G E +S Sbjct: 120 -YL-----PKMDGIVQGYLEQWGKANEVIWYPQLRRMTFDVAATLFMG--------EKVS 165 Query: 219 LVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKN 278 + ET G F + LPN + + L L+K ++ Q Sbjct: 166 QNPQLFPWFETYIQG----LFSLPIPLPNTLFGKSQRARALLLAELEKIIKARQQQ--PP 219 Query: 279 SVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPE 338 S D G L + +P+ K L+ + AG +T+T+A+S + L + Sbjct: 220 SEEDALGILLAARDDNNQPLS--LPELKDQILL--LLFAGHETLTSALSSFCLLLGQHSD 275 Query: 339 IQRKIQKELDTV-IGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIP------HSTT 391 I+ ++++E + + + +E + +PYL+ + E R IP Sbjct: 276 IRERVRQEQNKLQLSQELTAETLKK--MPYLDQVLQEVLR-------LIPPVGGGFRELI 326 Query: 392 RDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLF 451 +D GF+ PK V Q + DP+L+ DP +F PERF T DG+A + P + F Sbjct: 327 QDCQFQGFHFPKGWLVSYQISQTHADPDLYPDPEKFDPERF-TPDGSATHNP-PFAHVPF 384 Query: 452 GMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLT 492 G G R C+G+ A+ E+ LF L+QQ ++++ PG ++L Sbjct: 385 GGGLRECLGKEFARLEMKLFATRLIQQFDWTLLPGQNLELV 425 >3MDV-A nrPDB Length = 456 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 92/440 (20%), Positives = 185/440 (42%), Gaps = 54/440 (12%) Query: 69 SQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSL----T 124 +++YG V+++ + ++++ +++++ L+ + +Y + G+ L Sbjct: 20 AKKYGPVVRVNVFHKTSVIVTSPESVKKFLM--STKYNKDSKMYRALQTVFGERLFGQGL 77 Query: 125 FSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPG 184 S + W +RR+ A + S+ S L E +++A+ L+ L+ G Sbjct: 78 VSECNYERWHKQRRVIDLAFSRSSLVS---------LMETFNEKAEQLVEILEAKADGQT 128 Query: 185 HFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRY 244 + + + +++ FG + +L K + V+ G + ++ Sbjct: 129 PVSMQDMLTYTAMDILAKAAFGME----TSMLLGAQKPLSQAVKLMLEGITASRNTLAKF 184 Query: 245 LPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQ 304 LP Q + V+E + F + RD + K+G +++ Q Sbjct: 185 LPGKRKQ-------------LREVRESIR-FLRQVGRDWVQRRREALKRGEEVPADILTQ 230 Query: 305 -----------EKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGR 353 E +++ F AG +T +++++M L +PEI ++Q E+D VIG Sbjct: 231 ILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGS 290 Query: 354 ERRPRLSDRPQLPYLEAFILETFRHS--SFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQ 411 +R D +L YL + E+ R ++ F + +T ++G +P + + Sbjct: 291 KRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEE---ETLIDGVRVPGNTPLLFST 347 Query: 412 WQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLF 471 + + +EDP F P+RF G KP F +G R CIG+ A+ E+ + Sbjct: 348 YVMGRMDTYFEDPLTFNPDRF----GPGAPKP-RFTYFPFSLGHRSCIGQQFAQMEVKVV 402 Query: 472 LAILLQQLEFSVPPGVKVDL 491 +A LLQ+LEF + PG + L Sbjct: 403 MAKLLQRLEFRLVPGQRFGL 422 >3JUS-A nrPDB Length = 461 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 104/460 (22%), Positives = 185/460 (40%), Gaps = 44/460 (9%) Query: 35 VPKGLKSPPEPWG-WPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDT 93 +P G+KSPP + P LGH + GK+P L ++YG V + L D Sbjct: 6 LPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDA 65 Query: 94 IRQALVRQGDDFKGRPDLYTS-TLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASD 152 + +D D+Y+ T G+ + + + PV+ ++++ ++ LN Sbjct: 66 AALLFNSKNEDLNAE-DVYSRLTTPVFGKGVAYDVPN-PVFLEQKKMLKSGLNI------ 117 Query: 153 PASSSSCYLEEHVS---KEAKALISRLQELMAGPGH-FDPYNQVVVSVANVIGAMCFGQH 208 + ++HVS KE K E +G + F+ +++++ A+ H Sbjct: 118 ------AHFKQHVSIIEKETKEYFESWGE--SGEKNVFEALSELIILTAS---------H 160 Query: 209 FPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTV 268 + L + + G + + +LP P+ +R ++ K + Sbjct: 161 CLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAI 220 Query: 269 QEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISW 328 Q+ Q +K + DI L + K G + +++ ++ + AG T +T +W Sbjct: 221 QKRRQSQEK--IDDILQTLLDATYK----DGRPLTDDEVAGMLIGLLLAGQHTSSTTSAW 274 Query: 329 SLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDR-PQLPYLEAFILETFRHSSFLPFTIP 387 +L +Q+K E TV G P D+ L L+ I ET R P I Sbjct: 275 MGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRP--PIMIM 332 Query: 388 HSTTRD-TTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSE 446 R T+ G+ IP V V+ + W + +F P+R+L D A + + Sbjct: 333 MRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYL-QDNPASGEKFA- 390 Query: 447 KMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 486 + FG G+ RCIGE A +I + +L+ EF + G Sbjct: 391 -YVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDG 429 >6C94-A nrPDB Length = 497 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 48/188 (25%), Positives = 91/188 (48%), Gaps = 3/188 (1%) Query: 298 SGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRP 357 SG + + V+ G DT T+ ISW L + PE Q++ ++E+ ++G + Sbjct: 274 SGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQRCREEVREILGDQDSF 333 Query: 358 RLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHD 417 + D ++ YL + E FR +P + + ++G +P + ++ + ++ + Sbjct: 334 QWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKPVSFVDGRSLPAGSLISLHIYALHRN 393 Query: 418 PELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ 477 ++W DP F P RF + + ++ P + + F G R CIG+ A E+ + A+ L Sbjct: 394 SDVWPDPEVFDPLRF-SPENSSGRHPYA--FIPFSAGPRNCIGQQFAMNEMKVVTALCLL 450 Query: 478 QLEFSVPP 485 + EFSV P Sbjct: 451 RFEFSVDP 458 >6AYB-A nrPDB Length = 466 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 104/459 (22%), Positives = 182/459 (39%), Gaps = 50/459 (10%) Query: 37 KGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSR---LDT 93 KG P P P +G ++ KNP + S++YGDV I + L+ LDT Sbjct: 8 KGKLPPRVPNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFLNHPKILDT 67 Query: 94 IRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNT--FSIAS 151 +A D+ D+Y G + + DS + + + L T F + Sbjct: 68 FFKAT----DNELSLRDVYRFMRPVFGTGVVYDADSTERMMEQVKFVSSGLTTARFRVFV 123 Query: 152 DPASSSSCYLEEHVSKEAKAL----ISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207 D E+ ++ + K L + ELMA + ++ + + + Q Sbjct: 124 D-------IFEDEIAHKVKELGPEGTVDVAELMA--------DLIIFTASRCLLGDEVRQ 168 Query: 208 HFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRF-KAFNQRFLWFLQK 266 + E + L K H+ + S PL FF LP P + KA + F L K Sbjct: 169 YLSEKN-----LGKLYHDIDDGIS---PLSFF--YPSLPAPKRDKARKAVGEIFQELLDK 218 Query: 267 TVQEHYQDFDK---NSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVT 323 +EH + ++ S D+ L K + L +I L+ +F AG T + Sbjct: 219 RREEHKKHPERLLDESKMDVVDHLLTQKYKDGQ---ELTDVHRIGILIAGLF-AGQHTSS 274 Query: 324 TAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLP 383 SW+LM +++ ++ K++KE + ++G ++ ++ YLEA + E R L Sbjct: 275 ITSSWTLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPL- 333 Query: 384 FTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKP 443 I + + IPK + V+ + + +P F PER ++ Sbjct: 334 IMIMRMARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERLTERKE---HEK 390 Query: 444 LSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482 + FG G+ +CIGE A ++ ++ILL+ + Sbjct: 391 FKYGAVPFGAGRHKCIGENFALLQVKSIISILLRYFDME 429 >5JLC-A nrPDB Length = 515 Score = 71.6 bits (174), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 66/276 (23%), Positives = 119/276 (43%), Gaps = 43/276 (15%) Query: 238 FFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF-----DKNSV--RDITGALFKH 290 F PI PN L+ ++ + Q+ + Y +KN + RD+ L K+ Sbjct: 218 FTPINFVFPNLPLEHYRKRDH-----AQQAISGTYMSLIKERREKNDIQNRDLIDELMKN 272 Query: 291 SKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTV 350 S G + ++I NL+ + G T +W L++L +P++Q ++ +E V Sbjct: 273 ST---YKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQEQMRV 329 Query: 351 IGRERRPRLSDRPQ-LPYLEAFILETFR-----HSSFLPFTIPHSTTRDTTL--NGFYIP 402 + + + D Q +P L I ET R HS F RD + + +P Sbjct: 330 LNNDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLF------RKVMRDVAIPNTSYVVP 383 Query: 403 KKCCVFVNQWQVNHDPELWEDPSEFRPERF------LTADGT--------AINKPLSEKM 448 + V V+ + E + P+EF R+ +A G AI+K +S Sbjct: 384 RDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVSSPY 443 Query: 449 MLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVP 484 + FG G+ RCIGE+ A ++ + ++I ++ +++ P Sbjct: 444 LPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYP 479 >5FSA-A nrPDB Length = 490 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 109/493 (22%), Positives = 190/493 (38%), Gaps = 81/493 (16%) Query: 40 KSPPEPWGW-PLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 K+PP + W P G + G+ P+ Q+YGDV ++L ++ T+ L Sbjct: 4 KTPPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSF-------MLLGKIMTV--YL 54 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAA--------RRRLAQNALNTFSIA 150 +G +F ++ + L + + PV+ R + Q F++ Sbjct: 55 GPKGHEF-----VFNAKLSDVSAEEAYKHLTTPVFGTGVIYDCPNSRLMEQKKFAKFALT 109 Query: 151 SDPASSSSCYLEEHVSKEAKALIS-RLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHF 209 +D + E + S +L+E G VANV+ F Sbjct: 110 TDSFKRYVPKIREEILNYFVTDESFKLKEKTHG-------------VANVMKTQPEITIF 156 Query: 210 PES----SDEMLSLVKNTHE--FVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF 263 S DEM + + + + P++F + LP P R A ++ Sbjct: 157 TASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINF--VFPNLPLPHYWRRDAAQKKISAT 214 Query: 264 LQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVT 323 K ++ + D + RD+ +L HS G + ++I NL+ I G T Sbjct: 215 YMKEIKLRRERGDIDPNRDLIDSLLIHST---YKDGVKMTDQEIANLLIGILMGGQHTSA 271 Query: 324 TAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRP-----QLPYLEAFILETFR- 377 + +W L++L KP +Q I +E+ ++ +E+ L+D +LP + I ET R Sbjct: 272 STSAWFLLHLGEKPHLQDVIYQEVVELL-KEKGGDLNDLTYEDLQKLPSVNNTIKETLRM 330 Query: 378 ----HSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL 433 HS F T P + +PK V V+ + +++P +F P R+ Sbjct: 331 HMPLHSIFRKVTNPLRIPE----TNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWD 386 Query: 434 TADGTA-----------------INKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILL 476 TA A ++K +S + FG G+ RCIGE A ++ L + Sbjct: 387 TAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFV 446 Query: 477 QQLEFSVPPGVKV 489 L +++ G KV Sbjct: 447 YNLRWTI-DGYKV 458 >3MZS-A nrPDB Length = 486 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/237 (25%), Positives = 107/237 (45%), Gaps = 16/237 (6%) Query: 265 QKTVQEHYQDFD-KNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVT 323 +K + YQD K R+ G L+ K S ++ ++ N + ++ G +T + Sbjct: 240 EKYTEIFYQDLRRKTEFRNYPGILYCLLK-----SEKMLLEDVKAN-ITEMLAGGVNTTS 293 Query: 324 TAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQL-PYLEAFILETFRHSSFL 382 + W L + +Q +++E+ R+ +S Q+ P L+A I ET R + Sbjct: 294 MTLQWHLYEMARSLNVQEMLREEVLNA-RRQAEGDISKMLQMVPLLKASIKETLRLHP-I 351 Query: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442 T+ D L + IP K V V + + DP + P +F P R+L+ D I+ Sbjct: 352 SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHF 411 Query: 443 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTM 499 + + FG G R+C+G +A+ E+ LFL +L+ F V D+ I+ L + Sbjct: 412 ----RNLGFGWGVRQCVGRRIAELEMTLFLIHILEN--FKVEMQHIGDVDTIFNLIL 462 >3N9Z-A nrPDB Length = 487 Score = 65.1 bits (157), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 54/228 (23%), Positives = 94/228 (41%), Gaps = 20/228 (8%) Query: 256 FNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIF 315 + Q F W L++ H+ R I L SK + E I V ++ Sbjct: 240 YTQNFYWELRQKGSVHH------DYRGILYRLLGDSK---------MSFEDIKANVTEML 284 Query: 316 GAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILET 375 G DT + + W L + ++Q ++ E+ + + + +P L+A I ET Sbjct: 285 AGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKET 344 Query: 376 FRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTA 435 R + T+ D L + IP K V V + + +P + DP F P R+L+ Sbjct: 345 LRLHP-ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSK 403 Query: 436 DGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSV 483 D + + FG G R+C+G +A+ E+ +FL +L+ + Sbjct: 404 DKNIT----YFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEI 447 >6CR2-A nrPDB Length = 477 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 93/474 (19%), Positives = 180/474 (37%), Gaps = 57/474 (12%) Query: 40 KSPPEPWGW-PLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 K+PP + W P +G ++ G +P+ +YGD+ ++L + T+ L Sbjct: 4 KTPPVVFHWFPFIGSTISYGIDPYKFFFDCRAKYGDIFTF-------ILLGKKTTVY--L 54 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAAR--------RRLAQNALNTFSIA 150 +G+DF + L +S + PV+ + + Q + + Sbjct: 55 GTKGNDF-----ILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKYGLT 109 Query: 151 SDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFP 210 SD S ++ E ++ + G FD + G+ Sbjct: 110 SDALRSYVPL----ITDEVESFVKNSPAFQGHKGVFDVCKTIAEITIYTASRSLQGKEVR 165 Query: 211 ESSDEMLSLVKNTHEFVETASSG-NPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQ 269 D + E G P++F +L + P P ++ A ++ + ++ Sbjct: 166 SKFDSTFA------ELYHNLDMGFAPINF--MLPWAPLPHNRKRDAAQRKLTETYMEIIK 217 Query: 270 EHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWS 329 Q K D+ L K +G +P E+I +++ + AG + ++ SW Sbjct: 218 ARRQAGSKKDSEDMVWNLMSCVYK----NGTPVPDEEIAHMMIALLMAGQHSSSSTASWI 273 Query: 330 LMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFIL-ETFRHSSFLPFTIPH 388 ++ L T+P+I ++ +E V+G + P D Q L A ++ ET R + + +I Sbjct: 274 VLRLATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPI-HSIIR 332 Query: 389 STTRDTTLNG--FYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTA------- 439 + ++G + IP V + E + +P E+ P R+ + Sbjct: 333 AVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKV 392 Query: 440 ------INKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV 487 ++K + + FG G+ RCIGE A ++ A+L++ F PGV Sbjct: 393 DYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPGV 446 >5M0P-A nrPDB Length = 428 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 43/146 (29%), Positives = 67/146 (45%), Gaps = 14/146 (9%) Query: 356 RPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVN 415 R ++ P Y F E R+ F+PF +P D G IP + ++ + Sbjct: 274 REKIKSEPDYAY--KFAQEVRRYYPFVPF-LPGKAKVDIDFQGVTIPAGVGLALDVYGTT 330 Query: 416 HDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMG----KRRCIGEVLAKWEIFLF 471 HD LW+DP+EFRPERF T DG+ + ++ G G RC GE + + Sbjct: 331 HDESLWDDPNEFRPERFETWDGSPFD------LIPQGGGDYWTNHRCAGEWITVIIMEET 384 Query: 472 LAILLQQLEFSVPP-GVKVDLTPIYG 496 + +++ + VP ++VDL I G Sbjct: 385 MKYFAEKITYDVPEQDLEVDLNSIPG 410 >4WMZ-A nrPDB Length = 539 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 66/280 (23%), Positives = 117/280 (41%), Gaps = 42/280 (15%) Query: 238 FFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDK-----NSV--RDITGALFKH 290 F PI PN L+ ++ + QK + Y K N + RD+ +L K+ Sbjct: 236 FTPINFVFPNLPLEHYRKRDHA-----QKAISGTYMSLIKERRKNNDIQDRDLIDSLMKN 290 Query: 291 SKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTV 350 S G + ++I NL+ + G T +W L++L +P++Q+++ +E V Sbjct: 291 ST---YKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRV 347 Query: 351 IGRERRPRLSDRPQ-LPYLEAFILETFR-----HSSFLPFTIPHSTTRDTTL--NGFYIP 402 + ++ D Q +P L I ET R HS F +D + + IP Sbjct: 348 LDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLF------RKVMKDMHVPNTSYVIP 401 Query: 403 KKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGT-------------AINKPLSEKMM 449 V V+ + E + + +F R+ + AI+K +S + Sbjct: 402 AGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPYL 461 Query: 450 LFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKV 489 FG G+ RCIGE A ++ + ++I ++ L++ P G V Sbjct: 462 PFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTV 501 >2WX2-A nrPDB Length = 473 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 56/251 (22%), Positives = 104/251 (41%), Gaps = 22/251 (8%) Query: 238 FFPILRYLPNPALQRFKAFNQRFLWFLQKTV--QEHYQDFDKNSVRDITGALFKHSKKGP 295 F P L LP P R + L + + +E + N+ D+ G L K + Sbjct: 200 FMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNTSDLLGGLLKAVYR-- 257 Query: 296 RASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQR---KIQKELDTVIG 352 G + ++ ++ AG T T SWS+++L+ P+ ++ K+ KE+D Sbjct: 258 --DGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLM-HPKNKKWLDKLHKEIDEFPA 314 Query: 353 RERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQW 412 + + D ++P+ E + E+ R L + + + + +PK + + Sbjct: 315 QLNYDNVMD--EMPFAERCVRESIRRDPPL-LMVMRMVKAEVKVGSYVVPKGDIIACSPL 371 Query: 413 QVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFL 472 +HD E + +P + PER DG I FG G +CIG+ A ++ L Sbjct: 372 LSHHDEEAFPNPRLWDPERDEKVDGAFIG---------FGAGVHKCIGQKFALLQVKTIL 422 Query: 473 AILLQQLEFSV 483 A ++ +F + Sbjct: 423 ATAFREYDFQL 433 >2W0A-A nrPDB Length = 455 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 98/447 (21%), Positives = 171/447 (38%), Gaps = 53/447 (11%) Query: 52 GHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDL 111 GH+ +P + R+ GDV ++ V++LS + R GDD + Sbjct: 17 GHLEEFRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSG-SHANEFFFRAGDDDLDQAKA 75 Query: 112 YTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKA 171 Y G+++ F D+ P R+ + NA ++ + + +E+ V + Sbjct: 76 YPFMTPIFGEAVVF--DASP--ERRKEMLHNA----ALRGEQMKGHAATIEDQVRR---- 123 Query: 172 LISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETAS 231 +I+ E G D + A G+ F + D + + + E Sbjct: 124 MIADWGE----AGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKL-----YHELER 174 Query: 232 SGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQD--FDKNSVRDITGALF- 288 +PL + + YLP + +R + + + + DK S RD+ L Sbjct: 175 GTDPLAY--VDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDK-SDRDMLDVLIA 231 Query: 289 -KHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKEL 347 K PR S + +I + + AG T + SW+L+ L+ + + EL Sbjct: 232 VKAETGTPRFSAD-----EITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDEL 286 Query: 348 DTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR-DTTLNGFYIPKKCC 406 D + G R Q+P LE + ET R P I + + + G I + Sbjct: 287 DELYGDGRSVSFHALRQIPQLENVLKETLRLHP--PLIILMRVAKGEFEVQGHRIHEGDL 344 Query: 407 VFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMML------FGMGKRRCIG 460 V + N PE + DP +F P R+ +P E ++ FG G+ RC+G Sbjct: 345 VAASPAISNRIPEDFPDPHDFVPARY--------EQPRQEDLLNRWTWIPFGAGRHRCVG 396 Query: 461 EVLAKWEIFLFLAILLQQLEFSV--PP 485 A +I ++LL++ EF + PP Sbjct: 397 AAFAIMQIKAIFSVLLREYEFEMAQPP 423 >3S79-A nrPDB Length = 503 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 50/199 (25%), Positives = 93/199 (46%), Gaps = 11/199 (5%) Query: 302 IPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSD 361 + +E + + ++ A DT++ ++ + L + P ++ I KE+ TVIG ER ++ D Sbjct: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDD 349 Query: 362 RPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELW 421 +L +E FI E+ R+ + + D ++G+ + K + +N ++ H E + Sbjct: 350 IQKLKVMENFIYESMRYQPVVDLVM-RKALEDDVIDGYPVKKGTNIILNIGRM-HRLEFF 407 Query: 422 EDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEF 481 P+EF E F A N P FG G R C G+ +A + L LL++ Sbjct: 408 PKPNEFTLENF------AKNVPY-RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460 Query: 482 SVPPGVKVD-LTPIYGLTM 499 G V+ + I+ L++ Sbjct: 461 KTLQGQCVESIQKIHDLSL 479 >4KPA-A nrPDB Length = 494 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 63/229 (27%), Positives = 104/229 (45%), Gaps = 14/229 (6%) Query: 276 DKNSVRDITGALFKHSKKGPR-ASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLV 334 D+ + + + L H G +G + E I + AG +T + +S++L +LV Sbjct: 246 DRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLV 305 Query: 335 TKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLP-FTIPHSTTRD 393 P + +K +E V+ + P QL Y+ + E R P F++ D Sbjct: 306 KNPHVLQKAAEEAARVL-VDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSL--YAKED 362 Query: 394 TTLNGFY-IPKKCCVFVNQWQVNHDPELW-EDPSEFRPERFLTADGTAINKPLSEKMMLF 451 T L G Y + K + V Q++ D +W +D EFRPERF + +AI + F Sbjct: 363 TVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERF--ENPSAIPQ---HAFKPF 417 Query: 452 GMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMK 500 G G+R CIG+ A E L L ++L+ +F ++D+ LT+K Sbjct: 418 GNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKET--LTLK 464 >5HDI-A nrPDB Length = 404 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 61/259 (23%), Positives = 108/259 (41%), Gaps = 47/259 (18%) Query: 235 PLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKH---S 291 P+ L LP+P + + + L+ V+ ++ +++G +F+ + Sbjct: 149 PMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGVALMELSGYIFEQFDRA 208 Query: 292 KKGPR-----------ASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQ 340 PR ASG L V +V +F AG ++ + ++ L T+P+IQ Sbjct: 209 AADPRDNLLGELATACASGELDTLTAQVMMVT-LFAAGGESTAALLGSAVWILATRPDIQ 267 Query: 341 RKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRD-TTLNGF 399 ++++ P+L L AFI ET R+ PF + R+ TTL+G Sbjct: 268 QQVRAN----------------PEL--LGAFIEETLRYEP--PFRGHYRHVRNATTLDGT 307 Query: 400 YIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCI 459 +P + + N DP +E P EFR +++ + + FG G C+ Sbjct: 308 ELPADSHLLLLWGAANRDPAQFEAPGEFR-----------LDRAGGKGHISFGKGAHFCV 356 Query: 460 GEVLAKWEIFLFLAILLQQ 478 G LA+ E + L +LL + Sbjct: 357 GAALARLEARIVLRLLLDR 375 >3L4D-A nrPDB Length = 453 Score = 58.2 bits (139), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 88/454 (19%), Positives = 178/454 (39%), Gaps = 46/454 (10%) Query: 40 KSPPEPWGW-PLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 K PP G P +GH++ GK+P + + ++YG + + I + V+ + + Sbjct: 3 KLPPVVHGTTPFVGHIIQFGKDPLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQHSKFF 62 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 + + R ++Y+ + G+ + ++ P R +L A ++A + S Sbjct: 63 TPRNEILSPR-EVYSFMVPVFGEGVAYA---APYPRMREQLNFLA-EELTVAKFQNFAPS 117 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSD--EM 216 ++ V K KA ++ + G + + + N FG+ + D + Sbjct: 118 --IQHEVRKFMKANWNKDE------GEINILDDCSAMIINTACQCLFGEDLRKRLDARQF 169 Query: 217 LSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTV---QEHYQ 273 L+ + A+ F P + LP P R + L + + ++ Sbjct: 170 AQLLAKMESCLIPAAV-----FLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEEA 224 Query: 274 DFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYL 333 D N+ + G L + G R S Q ++ ++ AG T T +WSL++L Sbjct: 225 QKDTNTSDLLAGLLGAVYRDGTRMS-----QHEVCGMIVAAMFAGQHTSTITTTWSLLHL 279 Query: 334 VTKPEIQR---KIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHST 390 + P +R K+ +E+D + + + ++P+ E E+ R L + Sbjct: 280 M-DPRNKRHLAKLHQEIDEFPAQLNYDNVME--EMPFAEQCARESIRRDPPLVMLM-RKV 335 Query: 391 TRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT-ADGTAINKPLSEKMM 449 + + + +P+ + + + D E + +P E+ PER + DG Sbjct: 336 LKPVQVGKYVVPEGDIIACSPLLSHQDEEAFPNPREWNPERNMKLVDGAFCG-------- 387 Query: 450 LFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSV 483 FG G +CIGE ++ LA +L+ +F + Sbjct: 388 -FGAGVHKCIGEKFGLLQVKTVLATVLRDYDFEL 420 >2Y5N-A nrPDB Length = 417 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 66/297 (22%), Positives = 124/297 (41%), Gaps = 68/297 (22%) Query: 223 THEFVE-TASSGNPLDFFPI------------LRYLPNPALQRFKAFNQRFLWFLQKTVQ 269 HE V+ A++G P D + L +P+ RF ++ FL + T + Sbjct: 138 AHELVDQMAATGQPADLVAMFARQLPVRVICELLGVPSADHDRFTRWSGAFLSTAEVTAE 197 Query: 270 EHYQDFDKNSVRDITGALFKHSKKGP-----------RASGNLIPQEKIVNLVNDIFGAG 318 E + ++ G L +K P R + + ++++++L + AG Sbjct: 198 EMQEAAEQAYA--YMGDLIDRRRKEPTDDLVSALVQARDQQDSLSEQELLDLAIGLLVAG 255 Query: 319 FDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRH 378 +++ TT I+ + L+T+PE++R+ L DRP+L + + + E R Sbjct: 256 YESTTTQIADFVYLLMTRPELRRQ----------------LLDRPEL--IPSAVEELTR- 296 Query: 379 SSFLPFTI----PHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434 ++P + P D TL G I V + N D + D Sbjct: 297 --WVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPD----------- 343 Query: 435 ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDL 491 AD +++ ++ + FG G C+G LA+ E+ + L +LLQ+L PG+++ + Sbjct: 344 ADRIDVDRTPNQHLG-FGHGVHHCLGAPLARVELQVALEVLLQRL-----PGIRLGI 394 >2ZQJ-A nrPDB Length = 417 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 38/120 (31%), Positives = 54/120 (45%), Gaps = 11/120 (9%) Query: 369 EAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFR 428 E F+ E R+ F PF + +D N K V ++ + NHDP LW+ P EFR Sbjct: 277 EMFVQEVRRYYPFGPF-LGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFR 335 Query: 429 PERFLTADGTAINKPLSEKMMLFGMGK----RRCIGEVLAKWEIFLFLAILLQQLEFSVP 484 PERF + + M+ G G RC GE + + L L+ Q+E+ VP Sbjct: 336 PERFAEREENLFD------MIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVP 389 >3NC3-A nrPDB Length = 441 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 44/181 (24%), Positives = 75/181 (41%), Gaps = 21/181 (11%) Query: 299 GNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPR 358 G + + I+ L+ ++ A + ++ + +L+ PE + Sbjct: 251 GMALSDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDV--------------- 295 Query: 359 LSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDP 418 L+DR +P I ET R+ + IP ++DT + G I K VF N DP Sbjct: 296 LADRSLVPRA---IAETLRYKPPVQL-IPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDP 351 Query: 419 ELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQ 478 E +E P F R +A + + + + FG G C+G AK EI + I+L + Sbjct: 352 EAFEQPDVFNIHREDLGIKSAFSG--AARHLAFGSGIHNCVGTAFAKNEIEIVANIVLDK 409 Query: 479 L 479 + Sbjct: 410 M 410 >3TYW-A nrPDB Length = 417 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 41/181 (22%), Positives = 77/181 (42%), Gaps = 31/181 (17%) Query: 299 GNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPR 358 GN + E++++ + AG +T T+ I+ S + L+ +PE+ +++K+ D Sbjct: 232 GN-VTTEQLLSTLGITINAGRETTTSMIALSTLLLLDRPELPAELRKDPDL--------- 281 Query: 359 LSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDP 418 +P +L + +P + D L+G +P V NHDP Sbjct: 282 ------MPAAVDELLRVLSVADSIPLRV---AAEDIELSGRTVPADDGVIALLAGANHDP 332 Query: 419 ELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQ 478 E ++DP R + FG G +C+G+ LA+ E+ + L LL++ Sbjct: 333 EQFDDPERVDFHR------------TDNHHVAFGYGVHQCVGQHLARLELEVALETLLRR 380 Query: 479 L 479 + Sbjct: 381 V 381 >6FYJ-A nrPDB Length = 421 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 32/118 (27%), Positives = 58/118 (49%), Gaps = 3/118 (2%) Query: 367 YLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSE 426 Y + F+ E R F PF + +D T G+ + ++ + NHDPE+W++P Sbjct: 279 YSQMFVQEVRRFYPFFPFVVA-LVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDV 337 Query: 427 FRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVP 484 F P+RF +G+ + + + + MG RC GE + + + L L ++++ VP Sbjct: 338 FSPDRFAKWEGSPFS-FIPQGGGDYFMG-HRCAGEWVTIEVMKVSLDYLTNRMDYEVP 393 >3AWQ-A nrPDB Length = 415 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 36/122 (29%), Positives = 53/122 (43%), Gaps = 5/122 (4%) Query: 364 QLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWED 423 Q Y E F+ E R F P + ++ +D G P+ V ++ + NHD W D Sbjct: 270 QPDYAELFVQEVRRFYPFFPAVVARAS-QDFEWEGMAFPEGRQVVLDLYGSNHDAATWAD 328 Query: 424 PSEFRPERFLTADGTAIN-KPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482 P EFRPERF D + N P G RC GE + + + +L+ + + Sbjct: 329 PQEFRPERFRAWDEDSFNFIPQGGGDHYLG---HRCPGEWIVLAIMKVAAHLLVNAMRYD 385 Query: 483 VP 484 VP Sbjct: 386 VP 387 >5YSW-A nrPDB Length = 441 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 53/225 (23%), Positives = 90/225 (40%), Gaps = 39/225 (17%) Query: 264 LQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVT 323 L+ +Q D N DI L H+ P + ++++N+ N + AG+DT Sbjct: 229 LRAFMQALVTDKRANPAGDIISGLIHHAGADP-----ALTDDELINIANLLLIAGYDTTA 283 Query: 324 TAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLP 383 + + + L+ +P +L T+ R+ R++D + E R+ S + Sbjct: 284 SMLGLGIFVLLQRP-------AQLATL--RDDPSRIAD---------AVEELLRYLSVVN 325 Query: 384 FTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKP 443 I D G +IP V V+ N D W DP + +P Sbjct: 326 PGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDPD------------LDLTRP 373 Query: 444 LSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL---EFSVPP 485 + FG G +C+G+ LA+ E+ A LL++L +VPP Sbjct: 374 RGPHLA-FGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVPP 417 >3OFT-A nrPDB Length = 396 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 49/181 (27%), Positives = 75/181 (41%), Gaps = 32/181 (17%) Query: 312 NDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAF 371 N +FG G DTV I ++L PE QR +++ D + P +D Sbjct: 230 NLLFG-GLDTVAAMIGMVALHLARHPEDQRLLRERPDLI------PAAAD---------- 272 Query: 372 ILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPER 431 E R + + + D +G I K V++ N DP +E P E R +R Sbjct: 273 --ELMRR--YPTVAVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDR 328 Query: 432 FLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL-EFSVPPGVKVD 490 L P+ M G+G RC+G LA+ E+ +FL L + EF++ P V Sbjct: 329 GLA--------PIRHTTM--GVGAHRCVGAGLARMEVIVFLREWLGGMPEFALAPDKAVT 378 Query: 491 L 491 + Sbjct: 379 M 379 >6DCD-A nrPDB Length = 424 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 45/173 (26%), Positives = 72/173 (41%), Gaps = 30/173 (17%) Query: 307 IVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLP 366 +V +F AG +T ++ ++ L +P+IQR++ RE R + + Sbjct: 242 VVRSATFLFAAGQETTAKLLTAAMRVLGDRPDIQRRL---------RENRSLIPN----- 287 Query: 367 YLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSE 426 FI E+ R S + + R TT+ G I V V N DP +EDP E Sbjct: 288 ----FIEESLRMDSPVKSDSRLARKR-TTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHE 342 Query: 427 FRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 FR +++P + M F G C G LA+ E + L +L ++ Sbjct: 343 FR-----------LDRPNVREHMAFARGVHSCPGGPLARVEGRVSLERILDRM 384 >3SN5-A nrPDB Length = 491 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 51/182 (28%), Positives = 77/182 (42%), Gaps = 22/182 (12%) Query: 325 AISWSLMYLVTKPEIQRKIQKELD-TVIGRERRPRLSDRP---------QLPYLEAFILE 374 A WSL ++ PE + +E+ T+ ++ L P LP L++ I E Sbjct: 276 ATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKE 335 Query: 375 TFRHSSFLPFTIPHSTTRDTTL---NGFYIPKKCCVFVNQWQVNH-DPELWEDPSEFRPE 430 + R SS I + D TL +G Y +K + Q+ H DPE++ DP F+ + Sbjct: 336 SLRLSS-ASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYD 393 Query: 431 RFLTADGTAINK------PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVP 484 R+L +G L M FG G C G + A EI FL ++L E + Sbjct: 394 RYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELI 453 Query: 485 PG 486 G Sbjct: 454 EG 455 >6M7X-A nrPDB Length = 484 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 38/153 (24%), Positives = 65/153 (42%), Gaps = 15/153 (9%) Query: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQ-----LPY 367 ++ DT + +L L P +Q+ +++E +S+ PQ LP Sbjct: 287 ELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAAS-----ISEHPQKATTELPL 341 Query: 368 LEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEF 427 L A + ET R F + + D L ++IP V V + + +P L+ P + Sbjct: 342 LRAALKETLRLYPVGLF-LERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERY 400 Query: 428 RPERFLTADGTAINKPLSEKMMLFGMGKRRCIG 460 P+R+L G+ N + FG G R+C+G Sbjct: 401 NPQRWLDIRGSGRNF----YHVPFGFGMRQCLG 429 >2FR7-A nrPDB Length = 412 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 43/182 (23%), Positives = 77/182 (42%), Gaps = 32/182 (17%) Query: 298 SGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRP 357 +G + P+E + LV + AG DT I+ ++ L P+ +++ + P Sbjct: 233 TGEITPEEAPL-LVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRAD----------P 281 Query: 358 RLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHD 417 L+ + + EA E+ + F +TTRD L G I + V + N D Sbjct: 282 SLA---RNAFEEAVRFESPVQTFF------RTTTRDVELAGATIGEGEKVLMFLGSANRD 332 Query: 418 PELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ 477 P W+DP + R + + FG G C+G+++A+ E + LA L + Sbjct: 333 PRRWDDPDRYDITR------------KTSGHVGFGSGVHMCVGQLVARLEGEVVLAALAR 380 Query: 478 QL 479 ++ Sbjct: 381 KV 382 >4ZGX-A nrPDB Length = 489 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 46/198 (23%), Positives = 81/198 (40%), Gaps = 21/198 (10%) Query: 268 VQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAIS 327 +Q+ YQ+ N + TG + + K + E I ++ DT + Sbjct: 248 IQKIYQELAFNRPQHYTGIVAELLLKAE------LSLEAIKANSMELTAGSVDTTAFPLL 301 Query: 328 WSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQ-----LPYLEAFILETFRHSSFL 382 +L L P++Q+ +++E +S+ PQ LP L A + ET R Sbjct: 302 MTLFELARNPDVQQILRQESLAAAAS-----ISEHPQKATTELPLLRAALKETLRLYPVG 356 Query: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442 F + + D L ++IP V V + + + L+ P + P+R+L G+ N Sbjct: 357 LF-LERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNF 415 Query: 443 PLSEKMMLFGMGKRRCIG 460 + FG G R+C+G Sbjct: 416 ----HHVPFGFGMRQCLG 429 >2X2N-A nrPDB Length = 475 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 36/187 (19%), Positives = 77/187 (41%), Gaps = 14/187 (7%) Query: 299 GNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQ--RKIQKELDTVIGRERR 356 G + ++ ++ AG T + +WS+++L+ ++ ++KE++ + Sbjct: 259 GTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFPAQLNY 318 Query: 357 PRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNH 416 + D ++P+ E E+ R L + D + + +PK + + +H Sbjct: 319 NNVMD--EMPFAERCARESIRRDPPL-LMLMRKVMADVKVGSYVVPKGDIIACSPLLSHH 375 Query: 417 DPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILL 476 D E + +P + PER +G I FG G +CIG+ ++ LA Sbjct: 376 DEEAFPEPRRWDPERDEKVEGAFIG---------FGAGVHKCIGQKFGLLQVKTILATAF 426 Query: 477 QQLEFSV 483 + +F + Sbjct: 427 RSYDFQL 433 >1CPT-A nrPDB Length = 428 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 59/231 (25%), Positives = 93/231 (40%), Gaps = 44/231 (19%) Query: 264 LQKTVQEHYQDFDKNSV------RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGA 317 +T+ Y F+ +V +D +L +SK GN I + I I A Sbjct: 212 FHETIATFYDYFNGFTVDRRSCPKDDVMSLLANSK----LDGNYIDDKYINAYYVAIATA 267 Query: 318 GFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFR 377 G DT +++ +++ L PE Q + K +I PRL D + T Sbjct: 268 GHDTTSSSSGGAIIGLSRNPE-QLALAKSDPALI-----PRLVDEA--------VRWTAP 313 Query: 378 HSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADG 437 SF+ + DT + G I + + ++ N D E++ +P EF RF Sbjct: 314 VKSFM-----RTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITRF----- 363 Query: 438 TAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL---EFSVPP 485 + + FG G C+G+ LAK E+ +F LL +L E S PP Sbjct: 364 -------PNRHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSGPP 407 >4WPZ-A nrPDB Length = 397 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 52/190 (27%), Positives = 74/190 (38%), Gaps = 42/190 (22%) Query: 304 QEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRP 363 + +I+ L I AG +T IS L+ L+ PE K++ RE P+ D Sbjct: 219 EREIIALSIGILSAGHETTANQISMFLVTLLHNPEELDKLRD------NREAIPKAVD-- 270 Query: 364 QLPYLEAFILETFRHSSFLPFT-----IPHSTTRDTTLNGFYI-PKKCCVFVNQWQVNHD 417 E R F+P T IP TT + L+G + P V N D Sbjct: 271 ----------ELLR---FVPLTTTGGIIPRLTTAEVELSGGQVLPAGAVVLPAVATANRD 317 Query: 418 PELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ 477 PE++ED R N P + FG G C+G LA+ E+ L +L Sbjct: 318 PEVFEDGERLNVTRE--------NNP----HLAFGAGIHHCLGAQLARIELQEALGAILD 365 Query: 478 ---QLEFSVP 484 Q+ +VP Sbjct: 366 RMPQVRLAVP 375 >1EHE-A nrPDB Length = 403 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 34/127 (26%), Positives = 55/127 (43%), Gaps = 14/127 (11%) Query: 371 FILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPE 430 F+ E R+ + I + D + + + + N D E++E+P EF Sbjct: 275 FVEELCRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMN 334 Query: 431 RFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQ---LEFSVPPGV 487 R K + + FG G RCI E LAK E+ + L Q+ L+ +VP G Sbjct: 335 R----------KWPPQDPLGFGFGDHRCIAEHLAKAELTTVFSTLYQKFPDLKVAVPLG- 383 Query: 488 KVDLTPI 494 K++ TP+ Sbjct: 384 KINYTPL 390 >3MGX-A nrPDB Length = 415 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 46/183 (25%), Positives = 75/183 (40%), Gaps = 38/183 (20%) Query: 300 NLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQ---RKIQKELDTVIGRERR 356 +L + ++N N + G G +T AI+ ++ L T P + R ++DTV+ Sbjct: 238 DLTIDDVLLNCDNVLIG-GNETTRHAITGAVHALATVPGLLTALRDGSADVDTVVE---- 292 Query: 357 PRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNH 416 E R +S + TT D T+NG +P V N Sbjct: 293 -----------------EVLRWTSP-AMHVLRVTTADVTINGRDLPSGTPVVAWLPAANR 334 Query: 417 DPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILL 476 DP ++DP F P R KP + + FG G C+G LA+ E+ + L +L Sbjct: 335 DPAEFDDPDTFLPGR----------KP--NRHITFGHGMHHCLGSALARIELSVVLRVLA 382 Query: 477 QQL 479 +++ Sbjct: 383 ERV 385 >5VWS-A nrPDB Length = 393 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 53/211 (25%), Positives = 80/211 (37%), Gaps = 36/211 (17%) Query: 298 SGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRP 357 G + E++VN + + AG T T I +++ L PE ++ ++ + Sbjct: 214 EGKRLDLEEVVNTASLLLLAGHLTTTVLIGNTMLCLWDHPEAEKAVRAD----------- 262 Query: 358 RLSDRPQLPYLEAFILETFRHSSFLPF-TIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNH 416 P L + A + E+ R S PF TTRD T+ G IP V NH Sbjct: 263 -----PSL--IPAALEESLRLRS--PFLQAGRVTTRDVTIAGETIPANRFVMAWILSANH 313 Query: 417 DPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILL 476 D + DP F R T + FG G C+G L + E + L LL Sbjct: 314 DDRRFPDPERFDLHRQTTGH------------IAFGHGVHFCLGAQLGRLEGRIALERLL 361 Query: 477 QQLEFSVP---PGVKVDLTPIYGLTMKHARC 504 + P G+ + I+G + RC Sbjct: 362 GRFTEIHPWPREGISFYQSAIFGASRMPVRC 392 >3P3Z-A nrPDB Length = 416 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 44/187 (23%), Positives = 73/187 (39%), Gaps = 32/187 (17%) Query: 306 KIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQL 365 ++ LV + AG++T ++ ++ P+ KI++ P L+ PQ Sbjct: 242 ELRTLVATVLVAGYETTNHQLALAMYDFAQHPDQWMKIKEN----------PELA--PQA 289 Query: 366 PYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPS 425 + E R S LP T D +NG IP VF+ + DP ++ D Sbjct: 290 ------VEEVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADAD 343 Query: 426 EFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPP 485 F I + FG G C+G LA+ E+ +A L +L+ PP Sbjct: 344 RFD-----------ITVKREAPSIAFGGGPHFCLGTALARLELTEAVAALATRLD---PP 389 Query: 486 GVKVDLT 492 + ++T Sbjct: 390 QIAGEIT 396 >6G71-A nrPDB Length = 405 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 41/173 (23%), Positives = 71/173 (41%), Gaps = 31/173 (17%) Query: 296 RASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRER 355 R++ +P E I + + G G + + S + L++ K+L+ V+ R Sbjct: 215 RSADYQMPLESIRSNIKMTIGGGLNEPRDVLGVSTLALLSS-------SKQLELVL---R 264 Query: 356 RPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVN 415 P+L A E+ R + + +P T DT L+G++IP+ + + N Sbjct: 265 DPKL--------WGAVFEESIRWVAPIGM-VPRQTVVDTELDGYFIPRGAKLGLCILSAN 315 Query: 416 HDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEI 468 D +W DP F ER SE + FG G C+G A+ ++ Sbjct: 316 RDRSVWSDPDRFDIERG------------SEAHLAFGKGVHVCLGAWAARSQV 356 >3ABA-A nrPDB Length = 403 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 44/195 (22%), Positives = 74/195 (37%), Gaps = 36/195 (18%) Query: 307 IVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLP 366 ++N + A DT I L+ P+ Q + +E +++G Sbjct: 227 LMNAAGTLLIAAHDTTACMIGLGTALLLDSPD-QLALLREDPSLVGNA------------ 273 Query: 367 YLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSE 426 + E R+ + F TRD L G I K V + + DP E+P Sbjct: 274 -----VEELLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPER 328 Query: 427 FRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 486 F R +P + FG G +CIG+ LA+ E+ + L ++L PG Sbjct: 329 FDITR----------RPAPH--LAFGFGAHQCIGQQLARIELQIVFETLFRRL-----PG 371 Query: 487 VKVDLTPIYGLTMKH 501 +++ P+ L +H Sbjct: 372 LRL-AKPVEELRFRH 385 >5YHJ-A nrPDB Length = 413 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 44/193 (22%), Positives = 78/193 (40%), Gaps = 32/193 (16%) Query: 298 SGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTK----PEIQRKIQKELDTVIGR 353 SG L+P+E + V +I T AIS +++ V P+++ +++ Sbjct: 221 SGELLPEEVVAVEVLNILRP-----TVAISVYVLFTVLALHQFPDVKEQVE--------- 266 Query: 354 ERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQ 413 R ++ E F+ E R F P T D +G+ P+ ++ + Sbjct: 267 --------RGEVSKTE-FVQEVRRFYPFFPVAAARVKT-DFEWDGYAFPEGTLTLLDLYG 316 Query: 414 VNHDPELWEDPSEFRPERFLTADGTAIN-KPLSEKMMLFGMGKRRCIGEVLAKWEIFLFL 472 NHD +W +P F P RF + N P + FG RC GE + + + Sbjct: 317 TNHDVSIWTEPDRFDPSRFKDWKESPFNFIPQGGGDVDFG---HRCAGEHVTIAILAQVI 373 Query: 473 AILLQQLEFSVPP 485 + ++ ++VPP Sbjct: 374 ELFTKEYAYTVPP 386 >4YT3-A nrPDB Length = 410 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 47/206 (22%), Positives = 80/206 (38%), Gaps = 40/206 (19%) Query: 278 NSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAIS---WSLMYLV 334 N DI L K G + +++V I GAG +T + ++ +SL+Y Sbjct: 209 NPADDIISDLLK-----SEVDGEMFTDDEVVRTTMLILGAGVETTSHLLANSFYSLLY-- 261 Query: 335 TKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDT 394 E+ +++ + LD V PQ +E F + + D Sbjct: 262 DDKEVYQELHENLDLV------------PQ-------AVEEMLRFRFNLIKLDRTVKEDN 302 Query: 395 TLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMG 454 L G + + V V N D E++EDP I++P ++K + FG G Sbjct: 303 DLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLN-----------IHRPNNKKHLTFGNG 351 Query: 455 KRRCIGEVLAKWEIFLFLAILLQQLE 480 C+G LA+ E + L L++ + Sbjct: 352 PHFCLGAPLARLEAKIALTAFLKKFK 377 >3TKT-A nrPDB Length = 450 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 25/92 (27%), Positives = 43/92 (46%), Gaps = 12/92 (13%) Query: 389 STTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKM 448 + DT L G I + +N NHDP + +P +F P R + + Sbjct: 342 TAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTR------------PANRH 389 Query: 449 MLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480 + FG G +C+G LA+ E+ + L +LL +++ Sbjct: 390 LAFGAGSHQCLGLHLARLEMRVLLDVLLDRVD 421 >4DO1-A nrPDB Length = 410 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 44/183 (24%), Positives = 72/183 (39%), Gaps = 34/183 (18%) Query: 298 SGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKP-EIQRKIQKELDTVIGRERR 356 +G + P E + LV + AG DT I ++ L P E+QR D + R Sbjct: 231 TGEITPDEAPL-LVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRL---RSDPTLARNA- 285 Query: 357 PRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNH 416 + EA E+ + F +TTR+ L G I + V + N Sbjct: 286 ----------FEEAVRFESPVQTFF------RTTTREVELGGAVIGEGEKVLMFLGSANR 329 Query: 417 DPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILL 476 DP W DP + R + + FG G C+G+++A+ E + L+ L Sbjct: 330 DPRRWSDPDLYDITRKTSG------------HVGFGSGVHMCVGQLVARLEGEVMLSALA 377 Query: 477 QQL 479 +++ Sbjct: 378 RKV 380 >4Z5Q-A nrPDB Length = 423 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 59/251 (23%), Positives = 105/251 (41%), Gaps = 49/251 (19%) Query: 264 LQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVT 323 LQK ++ ++ D+T AL + R + + + + +++ L I GF+T Sbjct: 215 LQKYFEDLVKERRAEPRDDLTSALIE-----ARDAHDRLAEPELIGLCISILIGGFETTA 269 Query: 324 TAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLP 383 + IS S ++++ QR RE RL P+ + A + E R F+P Sbjct: 270 SEIS-SFVHVLQ----QR-----------RELWTRLCADPE--AIPAAVEELLR---FVP 308 Query: 384 FTI----PHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTA 439 F P D T+ G + + V V+ VN D + F AD Sbjct: 309 FAANGISPRYALEDMTVGGVLVREGEPVIVDTSAVNRDGLV-----------FDNADEVV 357 Query: 440 INKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKV--DLTPIYGL 497 I++ + M+FG G C+G LA+ E+ L L++ + PG+++ D+ + Sbjct: 358 IDRA-DNRHMVFGHGAHHCLGAHLARVELQEALKALVEGM-----PGLRLSGDVEWKADM 411 Query: 498 TMKHARCEHVQ 508 ++ R HV+ Sbjct: 412 IIRAPRVMHVE 422 >2Z36-A nrPDB Length = 413 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 45/201 (22%), Positives = 76/201 (37%), Gaps = 34/201 (16%) Query: 287 LFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKE 346 LF R G L +V+L + AG +T IS ++ L++ PE + Sbjct: 216 LFSRQIARQRQEGTL-DHAGLVSLAFLLLTAGHETTANMISLGVVGLLSHPE-------Q 267 Query: 347 LDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCC 406 L V R ++ + E R+ + T D + G I Sbjct: 268 LTVVKANPGRTPMA-----------VEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEG 316 Query: 407 VFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKW 466 V V+ N DP +++DP+ ER + + FG G +C+G+ LA+ Sbjct: 317 VIVSMLSANWDPAVFKDPAVLDVERG------------ARHHLAFGFGPHQCLGQNLARM 364 Query: 467 EIFLFLAILLQQ---LEFSVP 484 E+ + L ++ L +VP Sbjct: 365 ELQIVFDTLFRRIPSLRLAVP 385 >5IT1-A nrPDB Length = 399 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 50/226 (22%), Positives = 82/226 (36%), Gaps = 39/226 (17%) Query: 254 KAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVND 313 +A R L + VQE N D+ AL + + P +I ++N Sbjct: 183 EAAGMRLGGLLYQLVQERR----ANPGDDLISALI--TTEDP---DGVIDDMFLMNAAGT 233 Query: 314 IFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFIL 373 + A DT I L+ +P+ +QK+ ++IG + Sbjct: 234 LLIAAHDTTACMIGLGTALLLDRPDQLALLQKD-PSLIGNA-----------------VE 275 Query: 374 ETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL 433 E R+ + F T+D + G I K V + + DP EDP F R Sbjct: 276 ELLRYLTIGQFGAERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDITR-- 333 Query: 434 TADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 +P + FG G +CIG+ LA+ E+ + L ++ Sbjct: 334 --------RPAPH--LAFGFGAHQCIGQQLARIELQIVFGTLFRRF 369 >4MM0-A nrPDB Length = 399 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 42/217 (19%), Positives = 87/217 (40%), Gaps = 30/217 (13%) Query: 262 WFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDT 321 W + E Y D + R+ G+ + A N + + +L + AG++ Sbjct: 181 WTAARDALESYLDGLVAAKRENPGSDLLSALVATAAEDNELTDHDVRSLSLILLLAGYEP 240 Query: 322 VTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSF 381 + + S++ L+ P+ +++++ P L L + + E R++ Sbjct: 241 ASNQLGSSVLTLLRFPDRLAELRRD----------------PGL--LPSAVEELMRYAPA 282 Query: 382 LPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAIN 441 + T D T+ +IP V + N DP ++DP+ R ++ Sbjct: 283 GDGALFRVTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTGLR-----------LD 331 Query: 442 KPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQ 478 +P ++ L G G C+G LA+ E+ + + LL++ Sbjct: 332 RPDNQHTAL-GHGIHFCLGAALARVELQVAIGALLRR 367 >5Y1I-A nrPDB Length = 403 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 37/178 (20%), Positives = 73/178 (41%), Gaps = 26/178 (14%) Query: 302 IPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSD 361 I Q+ + + GAG +T I+ + L+ PE ++ R SD Sbjct: 222 ITQDDAAGIGMMLLGAGHETTANMIALGTLALLENPEQLAEV--------------RDSD 267 Query: 362 RPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELW 421 P++ + + E R+ + T+ D + G I + N DP+L+ Sbjct: 268 DPKV--IVNTVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLY 325 Query: 422 EDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 + P+R I++ + + + FG G +C+G LA+ E+ + + LL+++ Sbjct: 326 PEA----PDRL------DIHRANARRHLAFGYGVHQCLGATLARVELQIVYSTLLRRI 373 >4GGV-A nrPDB Length = 418 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 47/208 (22%), Positives = 75/208 (36%), Gaps = 36/208 (17%) Query: 271 HYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSL 330 H + + D+ L + G R + N +IVN+ N + G T T + ++ Sbjct: 216 HVTERRRTPREDLLTHLVQAEVDGERLTDN-----EIVNVANILLVTGHITTTMTLGNTV 270 Query: 331 MYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHST 390 + L PE+ K++ +DR +P L S+ L T Sbjct: 271 LCLDADPEVAAKVR---------------ADRSLVPGAIEEALRVLSPSAAL----ARGT 311 Query: 391 TRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMML 450 +R+ + G IPK V + N DP + DP + P R Sbjct: 312 SREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDPTRD------------PNPHFG 359 Query: 451 FGMGKRRCIGEVLAKWEIFLFLAILLQQ 478 FG G C+G LA+ E + L L + Sbjct: 360 FGRGIHFCLGAPLARLEGRVALNALFDR 387 >2WIY-A nrPDB Length = 394 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 26/101 (25%), Positives = 43/101 (42%), Gaps = 15/101 (14%) Query: 380 SFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTA 439 SFL F T D + G I + N DPE+++DP F R Sbjct: 282 SFLRFP-----TEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTR-------- 328 Query: 440 INKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480 P + + + FG+G C G+++++ E A+L ++ E Sbjct: 329 --PPAASRNLSFGLGPHSCAGQIISRAEATTVFAVLAERYE 367 >2ZBZ-A nrPDB Length = 412 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 40/186 (21%), Positives = 72/186 (38%), Gaps = 33/186 (17%) Query: 302 IPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSD 361 I +E++++ + AG +T + S S++ L+ PE ++ +D Sbjct: 229 IDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALR---------------AD 273 Query: 362 RPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELW 421 R +P + E R+ + T D + G I V V N D ++ Sbjct: 274 RSLVP---GAVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTVY 330 Query: 422 EDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQ--- 478 EDP R + + FG G +C+G+ LA+ E+ + L L+ + Sbjct: 331 EDPDALDIHRS------------ARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPT 378 Query: 479 LEFSVP 484 L +VP Sbjct: 379 LRLAVP 384 >6GMF-A nrPDB Length = 397 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 49/223 (21%), Positives = 79/223 (35%), Gaps = 43/223 (19%) Query: 264 LQKTVQEHYQDFDK-------NSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFG 316 L+++ QE Y F + D+ L G + + ++++ N + Sbjct: 178 LERSTQEFYAYFSEVLEERRREPREDLISQLLAAEVDGEKLTAG-----EVLSFANTLLI 232 Query: 317 AGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETF 376 AG +T T+ I +L+ L PE Q +L V A + E Sbjct: 233 AGNETTTSLIGNALVALTDHPEQLAAAQADLSLV------------------PAVVEEVL 274 Query: 377 RHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTAD 436 R+ S I T D + IP + V N D + DP F R Sbjct: 275 RYESPAQ-CIFRQTMTDVEIGDERIPARSVVLPLLASANRDESRFPDPDRFDIHRD---- 329 Query: 437 GTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 ++ + FG+ CIG LA+ E + L +LL +L Sbjct: 330 --------TKGHLAFGLDIHFCIGAPLARLEAKVMLEVLLARL 364 >5DE9-A nrPDB Length = 410 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 43/176 (24%), Positives = 71/176 (40%), Gaps = 34/176 (19%) Query: 318 GFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFR 377 G + VT L+++PE+ +++ E E RPR D +L Sbjct: 242 GGEAVTNNSGQMFHLLLSRPELAERLRSE------PEIRPRAIDE---------LLRWIP 286 Query: 378 HSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADG 437 H + + + D + G I V+V+ N DPE++ DP ER Sbjct: 287 HRNAVGLS--RIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFER------ 338 Query: 438 TAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTP 493 + N +S FG G C G +LA+ E L + +L ++ PG+K+ + P Sbjct: 339 -SPNPHVS-----FGFGPHYCPGGMLARLESELLVDAVLDRV-----PGLKLAVAP 383 >3RWL-A nrPDB Length = 426 Score = 41.6 bits (96), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 42/183 (22%), Positives = 77/183 (42%), Gaps = 31/183 (16%) Query: 297 ASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERR 356 A+ N+ P+E + N++ I G G DT +++ ++ L P+ + Sbjct: 246 ATRNMTPEEYLGNVLLLIVG-GNDTTRNSMTGGVLALHKNPD----------------QF 288 Query: 357 PRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNH 416 +L P L +E + E R + L + + D+ L G I K V + + N Sbjct: 289 AKLKANPAL--VETMVPEIIRWQTPLAH-MRRTAIADSELGGKTIRKGDKVVMWYYSGNR 345 Query: 417 DPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILL 476 D E+ + P EF I++P + + FG G RC+G LA+ ++ + +L Sbjct: 346 DDEVIDRPEEF-----------IIDRPRPRQHLSFGFGIHRCVGNRLAEMQLRILWEEIL 394 Query: 477 QQL 479 + Sbjct: 395 TRF 397 >6HQG-A nrPDB Length = 425 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 49/192 (25%), Positives = 80/192 (41%), Gaps = 34/192 (17%) Query: 297 ASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERR 356 ++ N+ E + NL+ I G G DT IS S++ L P+ RK Sbjct: 243 STKNMDRMEYLGNLILLIVG-GNDTTRNTISGSVLALHQNPDQDRK-------------- 287 Query: 357 PRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNH 416 L + P L + A + ET R + L + + RD L G I + V + N Sbjct: 288 --LRENPGL--IPAMVSETIRWQTPLAY-MRRRAKRDFELGGKTIREGDKVAMWYVSGNR 342 Query: 417 DPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILL 476 D E+ + P+++ I +P + + FG G RC+G LA+ ++ + +L Sbjct: 343 DEEVIDRPNDY-----------WIERPRVRQHLSFGFGVHRCVGNRLAELQLKIIWEEIL 391 Query: 477 Q---QLEFSVPP 485 +LE PP Sbjct: 392 ARFPRLEVVGPP 403 >2VZM-A nrPDB Length = 436 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 56/293 (19%), Positives = 105/293 (35%), Gaps = 59/293 (20%) Query: 214 DEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLW----------- 262 D ML+ + +E+ + P+ L +P P F+ + F++ Sbjct: 152 DAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAM 211 Query: 263 -----FLQKTVQ-EHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFG 316 +L + + + QD + D+ AL + S + G+ + E+++ + + + Sbjct: 212 AEMSGYLSRLIDSKRGQDGE-----DLLSALVRTSDE----DGSRLTSEELLGMAHILLV 262 Query: 317 AGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETF 376 AG +T I+ + L++ P+ + R + L+ + E Sbjct: 263 AGHETTVNLIANGMYALLSHPDQLAAL------------------RADMTLLDGAVEEML 304 Query: 377 RHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTAD 436 R+ + L+G IP V V + PE + DP F R Sbjct: 305 RYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRD---- 360 Query: 437 GTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQ---LEFSVPPG 486 + + FG G CIG LA+ E + + LL++ L V PG Sbjct: 361 --------TAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPG 405 >6A7I-A nrPDB Length = 411 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 49/211 (23%), Positives = 83/211 (39%), Gaps = 39/211 (18%) Query: 278 NSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKP 337 N D+T AL S+ +G+ + E+IVN + I AG +T + I + L T P Sbjct: 206 NPGDDLTSALIAASE-----NGDHLTDEEIVNTLQLIIAAGHETTISLIVNVVEALQTHP 260 Query: 338 EIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLN 397 E ++K+ L+ IG + I ET R ++ + T D + Sbjct: 261 EQRKKV---LNGEIG---------------WDGVIEETLRWNTPTSHVLIRFATEDIEVG 302 Query: 398 GFYIPKKCCVFVNQWQVNHDPELW-EDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKR 456 +PK + ++ + D E + EF R + + FG G Sbjct: 303 DKILPKGEGLIISFGALGRDEEQYGPTAGEFDATR------------TPNRHIAFGHGPH 350 Query: 457 RCIGEVLAKWEIFLFLAILLQ---QLEFSVP 484 C G L++ E + L L + +L+ +VP Sbjct: 351 VCPGAALSRLEAGIALPALYERFPELDLAVP 381 >6G5O-A nrPDB Length = 399 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 40/183 (21%), Positives = 74/183 (40%), Gaps = 33/183 (18%) Query: 298 SGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRP 357 G + +E++ ++ F G DTV A++ S+ YL PE +++KE P Sbjct: 201 EGRKLTKEEVKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRKE----------P 250 Query: 358 RLSDRPQLPYLEAFILETFRHSSFLPFT-IPHSTTRDTTLNGFYIPKKCCVFVNQWQVNH 416 ++ R + E R+ F P T + T DT + + + + N Sbjct: 251 EITGRA--------VEEMIRY--FSPLTQMGRVVTEDTHVCEHAVKADSRISLCWASANR 300 Query: 417 DPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILL 476 D ++E+P+E +R +N + FG C+G A+ + + L L Sbjct: 301 DAAVFENPNEIVLDR-------KVNPHVG-----FGFSHHNCLGATHARQILKILLQTLA 348 Query: 477 QQL 479 Q++ Sbjct: 349 QKV 351 >6A7J-A nrPDB Length = 411 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 50/210 (23%), Positives = 85/210 (40%), Gaps = 37/210 (17%) Query: 278 NSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKP 337 N D+T AL S+ G+ + E+I+N + I AG +T + I + L P Sbjct: 206 NPGDDLTSALIAASE-----DGDHLTDEEILNTLQLIIAAGHETTISLIVNVVEALAIHP 260 Query: 338 EIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLN 397 E ++K+ LS ++P+ E I ET R ++ + T D + Sbjct: 261 EQRKKV---------------LSG--EIPW-EGVIEETLRWNTPTSHVLIRFATEDIEVG 302 Query: 398 GFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRR 457 +PK + V+ + D E ++ P D A P + + FG G Sbjct: 303 DKVLPKGEGLVVSFGALGRDEE------QYGP---TAGDFDATRTP--NRHIAFGHGPHV 351 Query: 458 CIGEVLAKWEIFLFLAILLQ---QLEFSVP 484 C G L++ E + L L + +L+ +VP Sbjct: 352 CPGAALSRLEAGIALPALYERFPELDLAVP 381 >5XNT-A nrPDB Length = 411 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 48/206 (23%), Positives = 82/206 (39%), Gaps = 40/206 (19%) Query: 278 NSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAIS---WSLMYLV 334 N DI L K G + +++V I GAG +T + ++ +SL+Y Sbjct: 209 NPADDIISDLLK-----AEVDGEMFTDDEVVRTTMLILGAGVETTSHLLANSFYSLLY-- 261 Query: 335 TKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDT 394 E+ +++ + LD V PQ + E R+ F + + D Sbjct: 262 DDKEVYQELHENLDLV------------PQA------VEEMLRYR-FNLIKLDRTVKEDN 302 Query: 395 TLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMG 454 L G + + V V N D E++ED A I++P ++K + FG G Sbjct: 303 DLLGVELKEGENVVVWMSAANLDEEMFED-----------AFTLNIHRPNNKKHLTFGNG 351 Query: 455 KRRCIGEVLAKWEIFLFLAILLQQLE 480 C+G LA+ E + L L++ + Sbjct: 352 PHFCLGAPLARLEAKIALTTFLKKFK 377 >1WIY-A nrPDB Length = 389 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 38/166 (22%), Positives = 73/166 (43%), Gaps = 32/166 (19%) Query: 302 IPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSD 361 +P+E+ ++ + AG +TV +A++WS + L +P+ Q+++ + + + Sbjct: 206 LPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRVAESEEAALAA-------- 257 Query: 362 RPQLPYLEAFILETFRHSSFLP-FTIPHSTTRDTTLNGFYIPKKCCVFVNQW--QVNHDP 418 + EA L + P + + R L +P+ + ++ + Q + P Sbjct: 258 -----FQEALRL-------YPPAWILTRRLERPLLLGEDRLPQGTTLVLSPYVTQRLYFP 305 Query: 419 ELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLA 464 E F+PERFL GT S + FG+G+R C+G A Sbjct: 306 E----GEAFQPERFLAERGTP-----SGRYFPFGLGQRLCLGRDFA 342 >5XJN-A nrPDB Length = 455 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 45/186 (24%), Positives = 74/186 (39%), Gaps = 34/186 (18%) Query: 299 GNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPR 358 G I +I +L+ + AG +T TT IS L+ PE + I + P+ Sbjct: 274 GQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILE----------NPK 323 Query: 359 LSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDP 418 L + A + E R+S + +DT + G I + V + N D Sbjct: 324 L--------IPAAVDEVLRYSGSI-VGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDE 374 Query: 419 ELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQ 478 +E+ EF I++ + + + FG G C+G +LAK L I L++ Sbjct: 375 ARFENGEEFD-----------ISRANAREHLSFGFGIHYCLGNMLAK----LQAKICLEE 419 Query: 479 LEFSVP 484 + VP Sbjct: 420 VTRLVP 425 >2RFC-A nrPDB Length = 343 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 38/161 (23%), Positives = 65/161 (40%), Gaps = 18/161 (11%) Query: 321 TVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSS 380 T+ I + ++ ++ E + + VI + P + D L F+ ET R+ S Sbjct: 174 TMDEKIKYIMLLIIGGNETTTNLIGNMIRVI--DENPDIID-DALKNRSGFVEETLRYYS 230 Query: 381 FLPFTIPHS-TTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTA 439 + F +PH D+ +N I K V V N D +++P F+ R Sbjct: 231 PIQF-LPHRFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFDEPDLFKIGR-------- 281 Query: 440 INKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480 E + FG+G C+G LA+ E + L +L + Sbjct: 282 -----REMHLAFGIGIHMCLGAPLARLEASIALNDILNHFK 317 >5GWE-A nrPDB Length = 405 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 45/186 (24%), Positives = 74/186 (39%), Gaps = 34/186 (18%) Query: 299 GNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPR 358 G I +I +L+ + AG +T TT IS L+ PE + I + P+ Sbjct: 224 GQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILE----------NPK 273 Query: 359 LSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDP 418 L + A + E R+S + +DT + G I + V + N D Sbjct: 274 L--------IPAAVDEVLRYSGSI-VGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDE 324 Query: 419 ELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQ 478 +E+ EF I++ + + + FG G C+G +LAK L I L++ Sbjct: 325 ARFENGEEFD-----------ISRANAREHLSFGFGIHYCLGNMLAK----LQAKICLEE 369 Query: 479 LEFSVP 484 + VP Sbjct: 370 VTRLVP 375 >2WIO-A nrPDB Length = 431 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 30/102 (29%), Positives = 42/102 (41%), Gaps = 15/102 (14%) Query: 368 LEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQW--QVNHDPELWEDPS 425 + A + E R+ P + +TT+ T + G IP V VN W N D + +DP Sbjct: 294 IPAIVEEVLRYRPPFP-QMQRTTTKATEVAGVPIPAD--VMVNTWVLSANRDSDAHDDPD 350 Query: 426 EFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWE 467 F P R K + FG G C+G LA+ E Sbjct: 351 RFDPSR----------KSGGAAQLSFGHGVHFCLGAPLARLE 382 >5XW2-A nrPDB Length = 419 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 52/212 (24%), Positives = 83/212 (39%), Gaps = 36/212 (16%) Query: 268 VQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAIS 327 ++EH + + D+ G L + G R + N IVN + AG+ T T I Sbjct: 212 LREHAAECRRRPRGDLMGKLIEAEVDGRRLTDN-----HIVNFAKMLLIAGYLTTTMLIG 266 Query: 328 WSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIP 387 +++ L + PE +++ +DR +P L + E+ R S + T Sbjct: 267 NTVLCLDSYPEQAARVR---------------ADRSLIPGL---LEESMRFLSPVAATY- 307 Query: 388 HSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEK 447 +TTRD + G + V V N D + +P F D T P Sbjct: 308 RATTRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPELF--------DMTRGPNP---- 355 Query: 448 MMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 + FG G C+G LA+ E + L LL + Sbjct: 356 HLGFGRGIHFCLGGPLARMEGRVALDHLLDRF 387 >1Q5D-A nrPDB Length = 419 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 60/303 (19%), Positives = 106/303 (34%), Gaps = 55/303 (18%) Query: 214 DEMLSLVKNTHEF--VETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEH 271 D++L EF V + G P+ L +P ++F+ F L + Sbjct: 131 DQLLDARSGQEEFDVVRDYAEGIPMRAISALLKVPAECDEKFRRFGSATARALGVGLVPR 190 Query: 272 YQDFDKNSVRDITGAL------FKHSKKGP------------RASGNLIPQEKIVNLVND 313 + K V +T L ++ P A G+ + +++V LV Sbjct: 191 VDEETKTLVASVTEGLALLHGVLDERRRNPLENDVLTMLLQAEADGSRLSTKELVALVGA 250 Query: 314 IFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFIL 373 I AG DT I+++++ L+ PE ++ E P L + + Sbjct: 251 IIAAGTDTTIYLIAFAVLNLLRSPEALELVKAE----------------PGL--MRNALD 292 Query: 374 ETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL 433 E R + L +D G I K VF+ D ++ P F R Sbjct: 293 EVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIPSALRDGTVFSRPDVFDVRRDT 352 Query: 434 TADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTP 493 +A + +G G C G LA+ E + + + ++ P +K+ TP Sbjct: 353 SAS------------LAYGRGPHVCPGVSLARLEAEIAVGTIFRRF-----PEMKLKETP 395 Query: 494 IYG 496 ++G Sbjct: 396 VFG 398 >6B11-A nrPDB Length = 440 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 47/226 (20%), Positives = 88/226 (38%), Gaps = 43/226 (19%) Query: 281 RDITGALFKHSKKG------PRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLV 334 R I+G + S G +A G + +++ + AG +T + ++ S++ L+ Sbjct: 237 RLISGKTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMSVLVLL 296 Query: 335 TKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDT 394 P R+ L+ P L L + E R+ S + + S T D Sbjct: 297 QHPTAWRE----------------LTVNPGL--LPGAVDELLRYLS-IADGLRRSATADI 337 Query: 395 TLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMG 454 ++G I + N D ++ +P F R + + + FG G Sbjct: 338 EIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHRS------------ARRHVAFGYG 385 Query: 455 KRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMK 500 +C+G+ LA+ E+ + L +L++L P T + GL +K Sbjct: 386 PHQCLGQNLARMELEVALGAVLERLPALRP------TTDVAGLRLK 425 >3A50-A nrPDB Length = 411 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 40/170 (23%), Positives = 67/170 (39%), Gaps = 30/170 (17%) Query: 298 SGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRP 357 G+ + QE++V + + AG +T I ++ L+T P+ QRK+ Sbjct: 217 DGDRLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPD-QRKL-------------- 261 Query: 358 RLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHD 417 L++ P L + + + E R S + T D T +G IP V + N D Sbjct: 262 -LAEDPSL--ISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRD 318 Query: 418 PELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWE 467 + +P +T D + + FG G C+G LA+ E Sbjct: 319 ADWMPEPDRLD----ITRDASG--------GVFFGHGIHFCLGAQLARLE 356 >6M7L-A nrPDB Length = 404 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 46/193 (23%), Positives = 73/193 (37%), Gaps = 38/193 (19%) Query: 296 RASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRER 355 R G I E++ L + + + + ++ + L+ PE Q L Sbjct: 223 RDHGADISDEELAGLCAVVMNSSVEQTESCLAAGTLLLLEHPE-----QFAL-------- 269 Query: 356 RPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVN 415 L +RP+L E + E R+ S P + T D + G I K VF + N Sbjct: 270 ---LRERPELG--EQAVEEIVRYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAAN 324 Query: 416 H-DPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAI 474 DP L DG I + S + + FG G C+G LA+ E+ + Sbjct: 325 RADPAL---------------DGFDITRKES-RHVAFGHGIHHCLGAPLARMELRIAFTT 368 Query: 475 LLQQ---LEFSVP 484 L+ + L +VP Sbjct: 369 LVSRFPSLRTAVP 381 >2IAG-A nrPDB Length = 482 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 23/73 (31%), Positives = 34/73 (46%), Gaps = 6/73 (8%) Query: 417 DPELWEDPSEFRPERFLTADGTAI------NKPLSEKMMLFGMGKRRCIGEVLAKWEIFL 470 DPE++ DP F+ RFL DG+ K L M +G G C+G A I Sbjct: 372 DPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQ 431 Query: 471 FLAILLQQLEFSV 483 F+ ++L L+ + Sbjct: 432 FVFLVLVHLDLEL 444 Score = 35.4 bits (80), Expect = 0.059, Method: Compositional matrix adjust. Identities = 16/40 (40%), Positives = 24/40 (60%) Query: 49 PLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVL 88 P LG+ L GK+ L+RM +++GD+ I +G V VL Sbjct: 16 PWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVL 55 >6GK6-A nrPDB Length = 411 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 49/205 (23%), Positives = 82/205 (40%), Gaps = 41/205 (20%) Query: 286 ALFKHSKKGPR---ASGNLIPQEK--------IVNLVNDIFGAGFDTVTTAISWSLMYLV 334 AL +K PR SG L+ +E+ + ++V + AG +T I+ ++ L+ Sbjct: 201 ALADARRKAPRDDLISGLLLAEEQEHKLSPAELSSMVFLLLVAGHETTVHLIASGMLLLL 260 Query: 335 TKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDT 394 + P ERR RL + P L + + + E R + + D Sbjct: 261 SHPA---------------ERR-RLDEDPGL--VGSAVEEALRCEGPAELSTIRWSLEDI 302 Query: 395 TLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMG 454 L G +P V N DP+ + DP F G + N+ + FG G Sbjct: 303 ELFGARVPAGEGVAAGLLAANRDPQHFPDPDRF-------DIGRSPNRHIG-----FGGG 350 Query: 455 KRRCIGEVLAKWEIFLFLAILLQQL 479 C+G +LA+ E + + LL++L Sbjct: 351 IHFCLGAMLARIEAAIAFSTLLRRL 375 >2IJ7-A nrPDB Length = 396 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 37/175 (21%), Positives = 70/175 (40%), Gaps = 34/175 (19%) Query: 315 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILE 374 FGAG + + ++ +L+ L+ +P++ R L ++P+L + A + E Sbjct: 231 FGAGVISTGSFLTTALISLIQRPQL----------------RNLLHEKPEL--IPAGVEE 272 Query: 375 TFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434 R + +P T D + + K V V N DPE + +P Sbjct: 273 LLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIE------ 326 Query: 435 ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKV 489 +++P + FG G+ C G L + + + LL+++ PGV + Sbjct: 327 -----LDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKM-----PGVDL 371 >6HQW-A nrPDB Length = 445 Score = 38.1 bits (87), Expect = 0.010, Method: Compositional matrix adjust. Identities = 46/183 (25%), Positives = 79/183 (43%), Gaps = 35/183 (19%) Query: 297 ASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERR 356 A ++ PQE + NLV I G G DT +S +++ + K QR++ + ++I Sbjct: 264 AMNHMSPQEFMGNLVLLIVG-GNDTTRNTMS-GIVHALDKFPDQRELLERDASLIPNA-- 319 Query: 357 PRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNH 416 + E R+ + L + + T DT L G I V + N Sbjct: 320 ---------------VQECIRYVTPLAH-MRRTATADTELFGNQIKAGEKVILWYISANR 363 Query: 417 DPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILL 476 D ++E+P D +++P + + + FG G RC+G LA+ L L ILL Sbjct: 364 DETVFENP-----------DKLMVDRPNARRHLSFGHGIHRCVGARLAE----LQLRILL 408 Query: 477 QQL 479 +++ Sbjct: 409 EEM 411 >3B98-A nrPDB Length = 475 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 23/63 (36%), Positives = 31/63 (49%), Gaps = 4/63 (6%) Query: 27 VLKGLRPRVPKGLKSPPEPWGW-PLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPV 85 VL G R R PP G P LGH L GK+ L+RM +++GD+ +R + Sbjct: 8 VLYGRRTRRRN---EPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYI 64 Query: 86 LVL 88 VL Sbjct: 65 TVL 67 Score = 37.0 bits (84), Expect = 0.020, Method: Compositional matrix adjust. Identities = 40/140 (28%), Positives = 65/140 (46%), Gaps = 22/140 (15%) Query: 325 AISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQ-LPYLEAFILETFRHSSFLP 383 A W + YL+T PE R +++E I + RL +R + P ++ + ET R ++ Sbjct: 272 AAFWVMGYLLTHPEALRAVREE----IQGGKHLRLEERQKNTPVFDSVLWETLRLTA--A 325 Query: 384 FTIPHSTTRDTTL---NG--FYIPK--KCCVFVNQWQVNHDPELWEDPSEFRPERFLTAD 436 I T+D + NG +++ + + CVF DP++ + P F+ +RFL AD Sbjct: 326 ALITRDVTQDKKICLSNGQEYHLRRGDRLCVFPF-ISPQMDPQIHQQPEMFQFDRFLNAD 384 Query: 437 GTAINKPLSEKMMLFGMGKR 456 T EK F G R Sbjct: 385 RT-------EKKDFFKNGAR 397 >6F0B-A nrPDB Length = 395 Score = 37.4 bits (85), Expect = 0.016, Method: Compositional matrix adjust. Identities = 44/204 (21%), Positives = 79/204 (38%), Gaps = 36/204 (17%) Query: 286 ALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQK 345 +L + GP L E I ++ I G G+DT + IS SL+ +PE + + Sbjct: 203 SLIRRLVTGPYQEKQLTFHETIGVILMLIVG-GYDTTASTISLSLVSYALQPEKFSVVHE 261 Query: 346 ELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKC 405 ER P L + E R+ + + T D + G + Sbjct: 262 H------PERIPLL------------VEELLRYHTVSQLGLGRIATEDVEVGGVTVRAGQ 303 Query: 406 CVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAK 465 V N D ++ +P E ++P S + FG G +C+G+ LA+ Sbjct: 304 MVVAALPLANRDESVFPNPDELD-----------FDRP-SVPHVGFGYGPHQCVGQALAR 351 Query: 466 WEIFLFLAILLQQLEFSVPPGVKV 489 E+ + ++++L PG+++ Sbjct: 352 VELQEAIPAVIRRL-----PGMRL 370 >4OQR-A nrPDB Length = 457 Score = 37.0 bits (84), Expect = 0.019, Method: Compositional matrix adjust. Identities = 30/117 (25%), Positives = 51/117 (43%), Gaps = 15/117 (12%) Query: 372 ILETFRHSSFLPFTIPH-STTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPE 430 + E R+ S + P+ + D L G I K V + VN DP+++++P Sbjct: 311 VEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEP------ 364 Query: 431 RFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEI---FLFLAILLQQLEFSVP 484 D +++ + K FG G +C+G+ LA+ E+ F L L +VP Sbjct: 365 -----DILQLDRVDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVP 416 >5EX6-C nrPDB Length = 434 Score = 37.0 bits (84), Expect = 0.020, Method: Compositional matrix adjust. Identities = 44/205 (21%), Positives = 75/205 (36%), Gaps = 35/205 (17%) Query: 299 GNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPR 358 G+ + E++ + + AG D ++ I ++ L+ PE + Sbjct: 254 GDTVTDEELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAAL--------------- 298 Query: 359 LSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDP 418 R +P E + E R+ + P + D+T+ I V + N DP Sbjct: 299 ---RGDVPAAERAVDELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDP 355 Query: 419 ELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQ 478 L D D T P + FG G C+G LA+ E+ + L ++ Sbjct: 356 ALLPDADRL--------DVTREAVP----HVAFGHGVHHCLGAALARLELRIAYTALWRR 403 Query: 479 ---LEFSVPPGV-KVDL-TPIYGLT 498 L + P G + L TP YG++ Sbjct: 404 FPDLRLADPDGATEFRLSTPAYGIS 428 >4OQS-A nrPDB Length = 433 Score = 37.0 bits (84), Expect = 0.022, Method: Compositional matrix adjust. Identities = 30/117 (25%), Positives = 51/117 (43%), Gaps = 15/117 (12%) Query: 372 ILETFRHSSFLPFTIPH-STTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPE 430 + E R+ S + P+ + D L G I K V + VN DP+++++P Sbjct: 272 VEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEP------ 325 Query: 431 RFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEI---FLFLAILLQQLEFSVP 484 D +++ + K FG G +C+G+ LA+ E+ F L L +VP Sbjct: 326 -----DILQLDRVDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVP 377 >1Z8P-A nrPDB Length = 404 Score = 36.6 bits (83), Expect = 0.025, Method: Compositional matrix adjust. Identities = 26/85 (30%), Positives = 36/85 (42%), Gaps = 16/85 (18%) Query: 387 PHSTTR----DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442 P +TTR + + G IP+ V V N DP+ + DP F +T D Sbjct: 288 PETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRFD----VTRD------ 337 Query: 443 PLSEKMMLFGMGKRRCIGEVLAKWE 467 + + FG G C+G LAK E Sbjct: 338 --TRGHLSFGQGIHFCMGRPLAKLE 360 >1LG9-A nrPDB Length = 398 Score = 36.6 bits (83), Expect = 0.026, Method: Compositional matrix adjust. Identities = 51/217 (23%), Positives = 78/217 (35%), Gaps = 59/217 (27%) Query: 299 GNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPR 358 G+ E++ + AG D ++ I ++ ++ PE ++D G E+ + Sbjct: 218 GDDATDEELRGFCVQVMLAGDDNISGMIGLGVLAMLRHPE-------QIDAFRGDEQSAQ 270 Query: 359 LSDRPQLPYLEAFILETFRHSSFLPFTIPHSTT-----RDTTLNGFYIPKKCCVFVNQWQ 413 + + E R+ T+P+S T D TL G I K V + Sbjct: 271 RA-----------VDELIRY-----LTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPA 314 Query: 414 VNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEI----- 468 N DP L D R +P+ + FG G C+G LA+ E+ Sbjct: 315 ANRDPALAPDVDRLDVTR----------EPIPH--VAFGHGVHHCLGAALARLELRTVFT 362 Query: 469 -------FLFLAILLQQLEFSVPPGVKVDLTPIYGLT 498 L LA Q EF + TP YGLT Sbjct: 363 ELWRRFPALRLADPAQDTEFRL-------TTPAYGLT 392 >6GII-A nrPDB Length = 479 Score = 36.2 bits (82), Expect = 0.035, Method: Compositional matrix adjust. Identities = 21/90 (23%), Positives = 40/90 (44%), Gaps = 11/90 (12%) Query: 390 TTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMM 449 TTR+ + G +P + + NHD ++DP F I + + + + Sbjct: 362 TTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFF-----------DIGRSNASEHL 410 Query: 450 LFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 FG G +C+G L + E+ + + L ++L Sbjct: 411 NFGYGAHQCLGRNLGRMEMQIMIEELSRRL 440 >2X9P-A nrPDB Length = 404 Score = 36.2 bits (82), Expect = 0.035, Method: Compositional matrix adjust. Identities = 51/229 (22%), Positives = 84/229 (36%), Gaps = 41/229 (17%) Query: 289 KHSKKGP----RASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQ 344 K ++ GP R + + ++++ +L + AG D+V + + ++ L P+ Sbjct: 209 KRAEPGPDIISRLNDGELTEDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPD------ 262 Query: 345 KELDTVIGRERRPRLSDRPQLPYLEAFILETFRHS-SFLPFTIPHSTTRDTTLNGFYIPK 403 +R L+D + +L T R S LP P + D G I Sbjct: 263 ---------QRAAALADPDVMARAVEEVLRTARAGGSVLP---PRYASEDMEFGGVTIRA 310 Query: 404 KCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVL 463 V + N D + P EF D P + FG G CIG L Sbjct: 311 GDLVLFDLGLPNFDERAFTGPEEF--------DAARTPNP----HLTFGHGIWHCIGAPL 358 Query: 464 AKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLR 512 A+ E+ L +L P ++ +L P+ L +K + A LR Sbjct: 359 ARLELRTMFTKLFTRL-----PELRPEL-PVEQLRLKEGQLSGGFAELR 401 >5Z9I-A nrPDB Length = 398 Score = 35.4 bits (80), Expect = 0.053, Method: Compositional matrix adjust. Identities = 43/182 (23%), Positives = 70/182 (38%), Gaps = 31/182 (17%) Query: 298 SGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRP 357 G + +I N+ N + G T I+ +++ L D ++ R Sbjct: 218 DGQKLNDSQISNIANRLLVNGHLTTAMLIANTMLCL--------------DAFSDQDARV 263 Query: 358 RLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHD 417 R +DR +P A + E+ R+ S + + +T + + G IPK + V N D Sbjct: 264 R-ADRSLVP---ALLEESMRYMSPI-CGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRD 318 Query: 418 PELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ 477 +E P F R A + FG G C+G LA+ E + ILL Sbjct: 319 ERQFEKPDVFDAGRSPNA------------HLGFGRGIHFCLGRQLARMESKAAVEILLD 366 Query: 478 QL 479 +L Sbjct: 367 RL 368 >4YZR-A nrPDB Length = 405 Score = 35.4 bits (80), Expect = 0.058, Method: Compositional matrix adjust. Identities = 31/131 (23%), Positives = 55/131 (41%), Gaps = 17/131 (12%) Query: 358 RLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHD 417 +L +P++ + + E R++S + D T G I + +F+ N D Sbjct: 266 KLKQQPEM--IATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRD 323 Query: 418 PELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ 477 P +E+P R + N+ +S FG G C+G LA+ E + LL+ Sbjct: 324 PNFFENPEILNINR-------SPNRHIS-----FGFGIHFCLGAPLARLEGHIAFKALLK 371 Query: 478 Q---LEFSVPP 485 + +E +V P Sbjct: 372 RFPDIELAVAP 382 >1UED-A nrPDB Length = 406 Score = 35.4 bits (80), Expect = 0.059, Method: Compositional matrix adjust. Identities = 43/198 (21%), Positives = 73/198 (36%), Gaps = 42/198 (21%) Query: 296 RASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRER 355 R G+ + E++ L + G +TV I + ++ L+ P Q EL Sbjct: 224 RDHGDNVTDEELKGLCTALILGGVETVAGMIGFGVLALLDNPG-----QIEL-------- 270 Query: 356 RPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVN 415 L + P+ E + E R+ S + P +D ++G I V + N Sbjct: 271 ---LFESPE--KAERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMAN 325 Query: 416 HDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAK---------- 465 D L DP R +D + FG G C+G LA+ Sbjct: 326 RDEALTPDPDVLDANRAAVSD------------VGFGHGIHYCVGAALARSMLRMAYQTL 373 Query: 466 WEIF--LFLAILLQQLEF 481 W F L LA+ ++++++ Sbjct: 374 WRRFPGLRLAVPIEEVKY 391 >5LIE-A nrPDB Length = 414 Score = 35.4 bits (80), Expect = 0.062, Method: Compositional matrix adjust. Identities = 47/199 (23%), Positives = 75/199 (37%), Gaps = 36/199 (18%) Query: 314 IFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFIL 373 +F AG +T +I+ L+ L P+ +L T+ R L I Sbjct: 250 LFSAGAETTRNSIAGGLLALAENPD-------QLQTL-----------RSDFELLPTAIE 291 Query: 374 ETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL 433 E R +S P + + +R +L G I V V + N DP +++ EF R Sbjct: 292 EIVRWTSPSP-SKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITR-- 348 Query: 434 TADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTP 493 KP + FG G C+G LA+ E+ + LL + V+V Sbjct: 349 --------KP--NPHLGFGQGVHYCLGANLARLELRVLFEELLSRFG-----SVRVVEPA 393 Query: 494 IYGLTMKHARCEHVQARLR 512 + + +H H+ LR Sbjct: 394 EWTRSNRHTGIRHLVVELR 412 >5L94-A nrPDB Length = 410 Score = 35.4 bits (80), Expect = 0.068, Method: Compositional matrix adjust. Identities = 59/211 (27%), Positives = 88/211 (41%), Gaps = 45/211 (21%) Query: 296 RASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT-KPEIQR-KIQKELDTVIGR 353 + G + E+IV + AG +T T IS ++ L+ K +R K +KEL Sbjct: 221 KEEGKQLTDEEIVGFSILLLIAGNETTTNLISNTIYCLMEDKASFERLKREKEL------ 274 Query: 354 ERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR-DTTLNGFYIPKKCCVFVNQW 412 L + I E R+ S P H + D TL G + K V W Sbjct: 275 --------------LPSGIEEVLRYRS--PVQALHRIVKEDVTLAGKKL--KAGEHVVPW 316 Query: 413 --QVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFL 470 + D E +EDP F+ +R KP M FG G C+G LA+ E + Sbjct: 317 MGSAHRDAEYFEDPEVFKIDR----------KP--NVHMAFGRGIHFCLGAPLARIEAKI 364 Query: 471 FLAILLQ---QLEFSVPPGVK-VDLTPIYGL 497 LA L+ Q+++S +K ++ T +YGL Sbjct: 365 MLAELIDRYPQMDWSPSFELKPIESTFVYGL 395 >3EJB-B nrPDB Length = 404 Score = 35.0 bits (79), Expect = 0.081, Method: Compositional matrix adjust. Identities = 41/163 (25%), Positives = 66/163 (40%), Gaps = 31/163 (19%) Query: 317 AGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETF 376 AG +T IS S++ L+ PE K+++ D +IG + E Sbjct: 234 AGHETTVNLISNSVLCLLQHPEQLLKLRENPD-LIG-----------------TAVEECL 275 Query: 377 RHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTAD 436 R+ S T + D + G I + V++ N DP ++ +P F R Sbjct: 276 RYESPTQMT-ARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITR----- 329 Query: 437 GTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 + N LS FG G C+G LA+ E + + LLQ++ Sbjct: 330 --SPNPHLS-----FGHGHHVCLGSSLARLEAQIAINTLLQRM 365 >2NZA-A nrPDB Length = 413 Score = 35.0 bits (79), Expect = 0.085, Method: Compositional matrix adjust. Identities = 24/97 (24%), Positives = 42/97 (43%), Gaps = 17/97 (17%) Query: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFG 452 D ++G I V+V+ N DP+++ DP +R + +G Sbjct: 303 DVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDRD------------PNPHLAYG 350 Query: 453 MGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKV 489 G C G VLA+ + L + LL++L PG+++ Sbjct: 351 NGHHFCTGAVLARMQTELLVDTLLERL-----PGLRL 382 >5H1Z-A nrPDB Length = 407 Score = 34.7 bits (78), Expect = 0.093, Method: Compositional matrix adjust. Identities = 16/48 (33%), Positives = 29/48 (60%), Gaps = 4/48 (8%) Query: 432 FLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 F AD +++P + + + FG G RC+G LA+ +I A+LL+++ Sbjct: 330 FENADRIIVDRPNARRHLAFGHGIHRCVGARLAELQI----AVLLEEM 373 >1GWI-A nrPDB Length = 411 Score = 34.7 bits (78), Expect = 0.099, Method: Compositional matrix adjust. Identities = 47/206 (22%), Positives = 81/206 (39%), Gaps = 36/206 (17%) Query: 282 DITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQR 341 D+T AL + S+ +G+ + +IV+ + + AG +T + I +++ L T PE QR Sbjct: 212 DLTSALIQASE-----NGDHLTDAEIVSTLQLMVAAGHETTISLIVNAVVNLSTHPE-QR 265 Query: 342 KIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYI 401 + V+ E A + ET R S+ + D + I Sbjct: 266 AL------VLSGEAE-----------WSAVVEETLRFSTPTSHVLIRFAAEDVPVGDRVI 308 Query: 402 PKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGE 461 P + V+ + D E P TAD + + + + FG G C G Sbjct: 309 PAGDALIVSYGALGRD-ERAHGP---------TADRFDLTRTSGNRHISFGHGPHVCPGA 358 Query: 462 VLAKWEIFLFLAILLQQ---LEFSVP 484 L++ E + L L + L+ +VP Sbjct: 359 ALSRMEAGVALPALYARFPHLDLAVP 384 >3BUJ-A nrPDB Length = 397 Score = 34.3 bits (77), Expect = 0.14, Method: Compositional matrix adjust. Identities = 43/170 (25%), Positives = 68/170 (40%), Gaps = 39/170 (22%) Query: 300 NLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRL 359 L+ + +IV+ V G +TV + + +++ L+ P+ +LD + RRP L Sbjct: 216 GLMSRNEIVSTVVTFIFTGHETVASQVGNAVLSLLAHPD-------QLDLL---RRRPDL 265 Query: 360 SDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR----DTTLNGFYIPKKCCVFVNQWQVN 415 L + E R+ + S TR D L G + + V V N Sbjct: 266 --------LAQAVEECLRYDPSV-----QSNTRQLDVDVELRGRRLRRDDVVVVLAGAAN 312 Query: 416 HDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAK 465 DP ++ P +F ER P+ M FG G R C+G LA+ Sbjct: 313 RDPRRYDRPDDFDIER----------DPVPS--MSFGAGMRYCLGSYLAR 350 >1ODO-A nrPDB Length = 408 Score = 34.3 bits (77), Expect = 0.14, Method: Compositional matrix adjust. Identities = 38/195 (19%), Positives = 75/195 (38%), Gaps = 33/195 (16%) Query: 282 DITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQR 341 D+T L + + G+ + E++ + + + AG++T I ++ L+T+P+ Sbjct: 209 DMTSLLI--AARDDEGDGDRLSPEELRDTLLLMISAGYETTVNVIDQAVHTLLTRPDQLA 266 Query: 342 KIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTL-NGFY 400 ++K ++ + + + ET RH + D L +G Sbjct: 267 LVRKG-----------------EVTWAD-VVEETLRHEPAVKHLPLRYAVTDIALPDGRT 308 Query: 401 IPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIG 460 I + + + N P+ ED F R + ++ + FG G C+G Sbjct: 309 IARGEPILASYAAANRHPDWHEDADTFDATRTV------------KEHLAFGHGVHFCLG 356 Query: 461 EVLAKWEIFLFLAIL 475 LA+ E+ L L L Sbjct: 357 APLARMEVTLALESL 371 >5D3U-A nrPDB Length = 427 Score = 34.3 bits (77), Expect = 0.14, Method: Compositional matrix adjust. Identities = 26/127 (20%), Positives = 51/127 (40%), Gaps = 17/127 (13%) Query: 374 ETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL 433 E R+++ FT +D + G I + + N D ++E P++F Sbjct: 306 EVLRYNASNQFTW-RVAAKDVEMGGVRIEAGQTLALFLGSANRDANMFERPNDFD----- 359 Query: 434 TADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTP 493 +++P S + + FG G C+ L ++ F LL + PG++ P Sbjct: 360 ------LDRPNSARHLSFGQGVHACLAAQLISLQLKWFYVALLNRF-----PGIRTAGEP 408 Query: 494 IYGLTMK 500 I+ ++ Sbjct: 409 IWNENLE 415 >5FYF-A nrPDB Length = 470 Score = 33.9 bits (76), Expect = 0.18, Method: Compositional matrix adjust. Identities = 43/178 (24%), Positives = 72/178 (40%), Gaps = 31/178 (17%) Query: 303 PQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDR 362 P E I NL I G G DT ++S L V E R+ +K L + Sbjct: 294 PMEFIGNLTLLIVG-GNDTTRNSMSGGL---VAMNEFPREFEK-------------LKAK 336 Query: 363 PQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWE 422 P+L + + E R + L + + +D L G I K V + N D ++ Sbjct: 337 PEL--IPNMVSEIIRWQTPLAY-MRRIAKQDVELGGQTIKKGDRVVMWYASGNRDERKFD 393 Query: 423 DPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480 +P +F I++ + M FG G RC+G LA+ ++ + +L++ + Sbjct: 394 NPDQF-----------IIDRKDARNHMSFGYGVHRCMGNRLAELQLRILWEEILKRFD 440 >3A1L-A nrPDB Length = 425 Score = 33.9 bits (76), Expect = 0.18, Method: Compositional matrix adjust. Identities = 23/87 (26%), Positives = 33/87 (37%), Gaps = 12/87 (13%) Query: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFG 452 D L IP+ V N DP + DP R +E+ + FG Sbjct: 311 DIRLGDHDIPRGSRVVALLGSANRDPARFPDPDVLDVHR------------AAERQVGFG 358 Query: 453 MGKRRCIGEVLAKWEIFLFLAILLQQL 479 +G C+G LA+ E + L LL + Sbjct: 359 LGIHYCLGATLARAEAEIGLRALLDGI 385 >5FOI-A nrPDB Length = 408 Score = 33.5 bits (75), Expect = 0.23, Method: Compositional matrix adjust. Identities = 35/178 (19%), Positives = 74/178 (41%), Gaps = 31/178 (17%) Query: 302 IPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSD 361 I +++VN + AG +T ++ S++ L+ PE +++++ Sbjct: 232 ITHQELVNNAVLLLAAGHETSANQVTLSVLTLLRHPETAAELREQ--------------- 276 Query: 362 RPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELW 421 P+L + + E R+ S + + + T D L I + + NHD + Sbjct: 277 -PEL--MPNAVDELLRYHS-IADGLRRAATADIVLGDHTIRAGDGLIILLSSANHDGNTF 332 Query: 422 EDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 + F I++P + + FG G +C+G+ LA+ E+ + L L +++ Sbjct: 333 GAEATF-----------DIHRP-ARHHVAFGYGPHQCLGQNLARLEMEVTLGKLFRRV 378 >2QBO-A nrPDB Length = 421 Score = 32.7 bits (73), Expect = 0.41, Method: Compositional matrix adjust. Identities = 43/195 (22%), Positives = 72/195 (36%), Gaps = 33/195 (16%) Query: 296 RASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRER 355 + +G I ++ + + G DTV +S+S+ +L PE Sbjct: 228 QVNGRPITSDEAKRMCGLLLVVGLDTVVNFLSFSMEFLAKSPE----------------H 271 Query: 356 RPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVN 415 R L +RP+ + A E R S + T D +G + K + + Q Sbjct: 272 RQELIERPE--RIPAACEELLRRFSLV--ADGRILTSDYEFHGVQLKKGDQILLPQMLSG 327 Query: 416 HDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAIL 475 D P R + T FG G C+G+ LA+ EI + L Sbjct: 328 LDERENACPMHVDFSRQKVSHTT------------FGHGSHLCLGQHLARREIIVTLKEW 375 Query: 476 LQQL-EFSVPPGVKV 489 L ++ +FS+ PG ++ Sbjct: 376 LTRIPDFSIAPGAQI 390 >5DQN-A nrPDB Length = 426 Score = 32.7 bits (73), Expect = 0.44, Method: Compositional matrix adjust. Identities = 29/118 (24%), Positives = 44/118 (37%), Gaps = 11/118 (9%) Query: 392 RDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLF 451 D L G I K V ++ N D E++EDP F I + + + Sbjct: 305 EDVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFN-----------ILRSPNPHVGFG 353 Query: 452 GMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQA 509 G G CIG LA+ I L + + P G L + +KH + ++ A Sbjct: 354 GTGAHYCIGANLARMTINLIFNAIADNMPDLKPIGAPERLKSGWLNGIKHWQVDYTGA 411 >5OMS-A nrPDB Length = 409 Score = 32.3 bits (72), Expect = 0.51, Method: Compositional matrix adjust. Identities = 37/158 (23%), Positives = 61/158 (38%), Gaps = 22/158 (13%) Query: 331 MYLVTKPEIQRKIQKELDTVIGRERRPR----LSDRPQLPYLEAFILETFRHSSFLPFTI 386 +Y+ +Q T++G RP + D P L + I E R +S + Sbjct: 241 IYVYLLGAMQEPGHGMASTLVGLFSRPEQLEEVVDDPTL--IPRAIAEGLRWTSPIWSAT 298 Query: 387 PHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSE 446 +T+ T+ G +P V ++ NHD +E PS++ R PL Sbjct: 299 ARISTKPVTIAGVDLPAGTPVMLSYGSANHDTGKYEAPSQYDLHR----------PPLPH 348 Query: 447 KMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVP 484 + FG G C G A + I L++L ++P Sbjct: 349 --LAFGAGNHACAGIYFAN----HVMRIALEELFEAIP 380 >5MLC-D nrPDB Length = 272 Score = 32.0 bits (71), Expect = 0.61, Method: Compositional matrix adjust. Identities = 19/50 (38%), Positives = 21/50 (42%), Gaps = 11/50 (22%) Query: 30 GLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIR 79 G R P G KSP PWG+P LG SR +Y D IR Sbjct: 230 GGEGRAPIGRKSPTTPWGYPALGR-----------RSRKRNKYSDNFIIR 268 >3IVF-A nrPDB Length = 371 Score = 31.6 bits (70), Expect = 0.94, Method: Compositional matrix adjust. Identities = 26/95 (27%), Positives = 41/95 (43%), Gaps = 13/95 (13%) Query: 23 LVFWVLKGLRPRVPKGLKSPPEPWGW------PLLGHVLTLGKNPHLALSRMSQRYGDVL 76 +V+ + +R R+P+ L PP +G P G L GK AL R GD + Sbjct: 24 MVYDACRMIRERIPEALAGPPNDFGLFLSDDDPKKGIWLEAGK----ALDYYMLRNGDTM 79 Query: 77 QIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDL 111 + R P+ + T++ +V DD K D+ Sbjct: 80 EYRKKQRPLKIRMLDGTVKTIMV---DDSKTVTDM 111 >4RM4-A nrPDB Length = 396 Score = 31.2 bits (69), Expect = 1.0, Method: Compositional matrix adjust. Identities = 49/222 (22%), Positives = 80/222 (36%), Gaps = 45/222 (20%) Query: 281 RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQ 340 +DI L + + G + SG E+++ + AG +T T IS ++ ++ P + Sbjct: 208 QDIISILVEAEETGEKLSG-----EELIPFCTLLLVAGNETTTNLISNAMYSILETPGVY 262 Query: 341 RKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFY 400 + L P+L + + E R + P + RDT + G Sbjct: 263 EE----------------LRSHPEL--MPQAVEEALRFRAPAP-VLRRIAKRDTEIGGHL 303 Query: 401 IPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIG 460 I + V N D ++ P F R + FG G C+G Sbjct: 304 IKEGDMVLAFVASANRDEAKFDRPHMFDIRRH------------PNPHIAFGHGIHFCLG 351 Query: 461 EVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTP-----IYGL 497 LA+ E + L L+ + P V +TP IYGL Sbjct: 352 APLARLEANIALTSLIS----AFPHMECVSITPIENSVIYGL 389 >4TRI-A nrPDB Length = 407 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 24/92 (26%), Positives = 39/92 (42%), Gaps = 12/92 (13%) Query: 388 HSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEK 447 + T DT +G + + + N D ++ DP FR +R P S Sbjct: 285 RTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDR----------NPNSH- 333 Query: 448 MMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 + FG G C+G LA+ E+ L +L++L Sbjct: 334 -VAFGFGTHFCLGNQLARLELRLMTERVLRRL 364 >5MV8-A nrPDB Length = 527 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 15/50 (30%), Positives = 26/50 (52%), Gaps = 1/50 (2%) Query: 175 RLQELM-AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNT 223 R+Q+++ GP P+ V + + +C +FP + EML +V NT Sbjct: 181 RIQKVLRTGPRKQPPHEVEVEAAEQNVSRICHKIYFPNDTSEMLEVVANT 230 >2KMA-A nrPDB Length = 178 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 26/95 (27%), Positives = 41/95 (43%), Gaps = 13/95 (13%) Query: 23 LVFWVLKGLRPRVPKGLKSPPEPWGW------PLLGHVLTLGKNPHLALSRMSQRYGDVL 76 +V+ + +R R+P+ L PP +G P G L GK AL R GD + Sbjct: 30 MVYDACRMIRERIPEALAGPPNDFGLFLSDDDPKKGIWLEAGK----ALDYYMLRNGDTM 85 Query: 77 QIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDL 111 + R P+ + T++ +V DD K D+ Sbjct: 86 EYRKKQRPLKIRMLDGTVKTIMV---DDSKTVTDM 117 >6BHV-A nrPDB Length = 271 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 20/63 (31%), Positives = 27/63 (42%), Gaps = 7/63 (11%) Query: 211 ESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAF----NQRFLWFLQK 266 E ++ + VKNTH A +D F I R QR+K F N+R LW + Sbjct: 68 EEAEIIRKYVKNTHATTHNAYDLEVIDIFKIER---EGECQRYKPFKQLHNRRLLWHGSR 124 Query: 267 TVQ 269 T Sbjct: 125 TTN 127 >2QTV-A nrPDB Length = 772 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 24/82 (29%), Positives = 41/82 (50%), Gaps = 16/82 (19%) Query: 386 IPHSTTRDT--TLNGFYIPKKCCVF-VNQWQVNHDPELWEDPSEFRPERFLTADGTAIN- 441 +P++ + T +LN F++P + F +NQ N P+ W P+ RP R A G+A+N Sbjct: 216 LPNAMNKVTPFSLNRFFLPLEQVEFKLNQLLENLSPDQWSVPAGHRPLR---ATGSALNI 272 Query: 442 ---------KPLSEKMMLFGMG 454 K + +++LF G Sbjct: 273 ASLLLQGCYKNIPARIILFASG 294 >4OQA-C nrPDB Length = 505 Score = 30.0 bits (66), Expect = 2.3, Method: Compositional matrix adjust. Identities = 20/63 (31%), Positives = 27/63 (42%), Gaps = 7/63 (11%) Query: 211 ESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAF----NQRFLWFLQK 266 E ++ + VKNTH A +D F I R QR+K F N+R LW + Sbjct: 292 EEAEIIRKYVKNTHATTHNAYDLEVIDIFKIER---EGECQRYKPFKQLHNRRLLWHGSR 348 Query: 267 TVQ 269 T Sbjct: 349 TTN 351 >3DBM-A nrPDB Length = 473 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 16/88 (18%) Query: 364 QLPYLEAFILETFRHSSFLP---------FTIPHSTTRDTTLNGFYIPKKCCVFVNQWQV 414 Q+P ++ + E+ R +P FTI + D T F + K +F Q Sbjct: 326 QMPLTKSVVYESLRIEPPVPPQYGKAKSNFTI---ESHDAT---FEVKKGEMLFGYQPFA 379 Query: 415 NHDPELWEDPSEFRPERFLTADGTAINK 442 DP++++ P E+ P+RF+ DG A+ K Sbjct: 380 TKDPKVFDRPEEYVPDRFV-GDGEALLK 406 >4UND-A nrPDB Length = 373 Score = 30.0 bits (66), Expect = 2.6, Method: Compositional matrix adjust. Identities = 20/63 (31%), Positives = 27/63 (42%), Gaps = 7/63 (11%) Query: 211 ESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAF----NQRFLWFLQK 266 E ++ + VKNTH A +D F I R QR+K F N+R LW + Sbjct: 171 EEAEIIRKYVKNTHATTHNAYDLEVIDIFKIER---EGECQRYKPFKQLHNRRLLWHGSR 227 Query: 267 TVQ 269 T Sbjct: 228 TTN 230 >3NV6-A nrPDB Length = 452 Score = 30.0 bits (66), Expect = 2.9, Method: Compositional matrix adjust. Identities = 19/46 (41%), Positives = 25/46 (54%), Gaps = 5/46 (10%) Query: 451 FGMGKRRCIGEVLAKWEIFLFLAILLQQL-EFSVPPGVKVDLTPIY 495 FG G RC G LA+ E+ + L L+++ EFS G TPIY Sbjct: 392 FGGGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGE----TPIY 433 >6MYA-A nrPDB Length = 499 Score = 29.6 bits (65), Expect = 3.6, Method: Compositional matrix adjust. Identities = 20/63 (31%), Positives = 28/63 (44%), Gaps = 3/63 (4%) Query: 187 DPYNQVVVSVANVIGA---MCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILR 243 D Y ++ S N G + +G H P SS+E SL N + +V SS F P + Sbjct: 158 DSYPKLTNSYVNNKGKEVLVLWGVHHPSSSNEQQSLYHNVNAYVSVVSSNYNRRFTPEIA 217 Query: 244 YLP 246 P Sbjct: 218 ARP 220 >6AH0-L nrPDB Length = 499 Score = 29.3 bits (64), Expect = 4.2, Method: Compositional matrix adjust. Identities = 27/91 (29%), Positives = 42/91 (46%), Gaps = 24/91 (26%) Query: 161 LEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAM-------------CFGQ 207 +EE++SK+AKA E+M GP P +V+V N+ + + + Sbjct: 67 IEEYISKQAKA-----SEVM-GPVEAAPEYRVIVDANNLTVEIENELNIIHKFIRDKYSK 120 Query: 208 HFPESSDEMLSLVKNTHEFVETASS-GNPLD 237 FP E+ SLV N +++ T GN LD Sbjct: 121 RFP----ELESLVPNALDYIRTVKELGNSLD 147 >6HA1-C nrPDB Length = 277 Score = 28.9 bits (63), Expect = 5.6, Method: Compositional matrix adjust. Identities = 13/23 (56%), Positives = 13/23 (56%) Query: 30 GLRPRVPKGLKSPPEPWGWPLLG 52 G R P G KSP PWG P LG Sbjct: 234 GGEGRAPIGRKSPMSPWGKPTLG 256 >5MYJ-BD nrPDB Length = 276 Score = 28.9 bits (63), Expect = 6.0, Method: Compositional matrix adjust. Identities = 13/23 (56%), Positives = 13/23 (56%) Query: 30 GLRPRVPKGLKSPPEPWGWPLLG 52 G R P G KSP PWG P LG Sbjct: 234 GGEGRQPVGRKSPMTPWGKPALG 256 >4M9C-A nrPDB Length = 216 Score = 28.5 bits (62), Expect = 7.2, Method: Compositional matrix adjust. Identities = 16/51 (31%), Positives = 25/51 (49%), Gaps = 1/51 (1%) Query: 196 VANVIGAMCFGQH-FPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYL 245 + V GA FG+ P + +L K F++ SG L+ +P+L YL Sbjct: 4 IIGVYGASGFGKEVMPLVRQQFPTLSKEQFAFIDDGLSGTTLNGYPVLSYL 54 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2HI4-A nrPDB 615 e-176 6DWN-A nrPDB 553 e-158 6B82-A nrPDB 471 e-133 2NNH-A nrPDB 460 e-130 5W0C-A nrPDB 458 e-129 4GQS-A nrPDB 456 e-128 1N6B-A nrPDB 447 e-126 4H1N-A nrPDB 435 e-122 3E6I-A nrPDB 433 e-121 2PG7-A nrPDB 425 e-119 5E58-A nrPDB 419 e-117 5E0E-A nrPDB 419 e-117 4R1Z-A nrPDB 416 e-116 4R20-A nrPDB 413 e-116 3IBD-A nrPDB 411 e-115 5UYS-A nrPDB 408 e-114 6IQ5-A nrPDB 399 e-111 3DL9-A nrPDB 392 e-109 5YLW-A nrPDB 386 e-107 3TBG-A nrPDB 378 e-105 5VBU-A nrPDB 354 6e-98 3QZ1-A nrPDB 354 7e-98 3JUS-A nrPDB 323 1e-88 6CR2-A nrPDB 323 1e-88 5FSA-A nrPDB 315 3e-86 6DA2-A nrPDB 308 2e-84 3L4D-A nrPDB 308 2e-84 4WMZ-A nrPDB 301 5e-82 5JLC-A nrPDB 298 3e-81 5VEU-A nrPDB 298 3e-81 2WX2-A nrPDB 297 1e-80 6AYB-A nrPDB 295 2e-80 2VE3-A nrPDB 286 2e-77 3EL3-A nrPDB 284 7e-77 3K9V-A nrPDB 283 2e-76 2W0A-A nrPDB 278 4e-75 2X2N-A nrPDB 269 2e-72 3MDV-A nrPDB 269 2e-72 6C94-A nrPDB 226 2e-59 4KPA-A nrPDB 209 2e-54 3MZS-A nrPDB 209 3e-54 3N9Z-A nrPDB 206 2e-53 3S79-A nrPDB 201 6e-52 5VWS-A nrPDB 188 5e-48 2VZM-A nrPDB 187 1e-47 4ZGX-A nrPDB 179 4e-45 3NC3-A nrPDB 173 1e-43 4Z5Q-A nrPDB 172 4e-43 3SN5-A nrPDB 171 7e-43 6M7X-A nrPDB 171 9e-43 2Y5N-A nrPDB 170 2e-42 2ZBZ-A nrPDB 169 3e-42 4GGV-A nrPDB 167 9e-42 3ABA-A nrPDB 165 4e-41 5Y1I-A nrPDB 163 2e-40 6GMF-A nrPDB 163 2e-40 2Z36-A nrPDB 163 3e-40 4YT3-A nrPDB 163 3e-40 5IT1-A nrPDB 162 3e-40 6A7J-A nrPDB 161 6e-40 6A7I-A nrPDB 161 9e-40 4WPZ-A nrPDB 158 4e-39 1EHE-A nrPDB 158 6e-39 3P3Z-A nrPDB 156 2e-38 1CPT-A nrPDB 154 9e-38 4MM0-A nrPDB 154 1e-37 6HQG-A nrPDB 152 4e-37 5YSW-A nrPDB 151 5e-37 6FYJ-A nrPDB 151 7e-37 5HDI-A nrPDB 150 1e-36 3TYW-A nrPDB 148 6e-36 3RWL-A nrPDB 145 5e-35 3MGX-A nrPDB 143 2e-34 2ZQJ-A nrPDB 142 4e-34 6DCD-A nrPDB 141 7e-34 5YHJ-A nrPDB 139 3e-33 3OFT-A nrPDB 138 6e-33 6G5O-A nrPDB 137 1e-32 5M0P-A nrPDB 136 3e-32 3TKT-A nrPDB 134 1e-31 3AWQ-A nrPDB 131 5e-31 2FR7-A nrPDB 131 6e-31 5DE9-A nrPDB 131 6e-31 2WIY-A nrPDB 128 5e-30 4DO1-A nrPDB 126 2e-29 6G71-A nrPDB 119 2e-27 Sequences not found previously or not previously below threshold: 3EJB-B nrPDB 177 1e-44 5L94-A nrPDB 169 2e-42 5CJE-A nrPDB 165 4e-41 5OFQ-A nrPDB 165 4e-41 4RM4-A nrPDB 164 8e-41 5XNT-A nrPDB 163 1e-40 4UBS-A nrPDB 161 6e-40 3WVS-A nrPDB 160 2e-39 4JBT-A nrPDB 159 3e-39 4YZR-A nrPDB 158 5e-39 4Z5P-A nrPDB 154 1e-37 3A50-A nrPDB 152 4e-37 5XW2-A nrPDB 151 8e-37 6GK6-A nrPDB 150 1e-36 4OQS-A nrPDB 150 2e-36 2WIO-A nrPDB 149 2e-36 3R9C-A nrPDB 149 3e-36 4OQR-A nrPDB 148 5e-36 5XJN-A nrPDB 148 6e-36 5GWE-A nrPDB 147 8e-36 1ODO-A nrPDB 147 1e-35 1Z8P-A nrPDB 146 2e-35 1GWI-A nrPDB 146 3e-35 3ABB-A nrPDB 145 4e-35 6B11-A nrPDB 145 4e-35 4XE3-A nrPDB 144 6e-35 5EX6-C nrPDB 144 7e-35 5NWS-A nrPDB 144 9e-35 1F4U-A nrPDB 144 1e-34 5FOI-A nrPDB 142 4e-34 5LIE-A nrPDB 141 6e-34 6F0B-A nrPDB 141 1e-33 5Z9I-A nrPDB 140 1e-33 5DQN-A nrPDB 138 4e-33 2RFC-A nrPDB 138 5e-33 1UED-A nrPDB 137 1e-32 4TRI-A nrPDB 137 1e-32 6HQW-A nrPDB 137 1e-32 2WM5-A nrPDB 136 2e-32 3A1L-A nrPDB 133 1e-31 6FSH-A nrPDB 131 7e-31 2XKR-A nrPDB 131 7e-31 6CVC-A nrPDB 131 1e-30 1Q5D-A nrPDB 131 1e-30 5FYF-A nrPDB 129 2e-30 1LG9-A nrPDB 129 2e-30 4TX3-A nrPDB 128 6e-30 3IVY-A nrPDB 127 9e-30 5H1Z-A nrPDB 127 1e-29 1UE8-A nrPDB 126 2e-29 5LIV-A nrPDB 126 2e-29 4PWV-A nrPDB 126 4e-29 6F88-A nrPDB 125 4e-29 5L1U-A nrPDB 125 4e-29 6GII-A nrPDB 125 6e-29 6HQD-A nrPDB 124 7e-29 6M7L-A nrPDB 124 9e-29 2UUQ-A nrPDB 122 3e-28 5HH3-A nrPDB 122 3e-28 2X9P-A nrPDB 121 9e-28 3WEC-A nrPDB 119 4e-27 2NZA-A nrPDB 118 5e-27 1WIY-A nrPDB 116 3e-26 5EX8-A nrPDB 114 1e-25 3OO3-A nrPDB 112 3e-25 2IAG-A nrPDB 109 2e-24 5D3U-A nrPDB 109 3e-24 6BLD-A nrPDB 108 7e-24 4FB2-A nrPDB 107 8e-24 3B98-A nrPDB 107 9e-24 2IJ7-A nrPDB 106 2e-23 5HIW-A nrPDB 105 3e-23 2QBO-A nrPDB 105 6e-23 5KYO-A nrPDB 104 9e-23 5OMS-A nrPDB 103 2e-22 3BUJ-A nrPDB 102 3e-22 3NV6-A nrPDB 94 1e-19 4C9K-A nrPDB 93 4e-19 2RCM-A nrPDB 77 2e-14 3DBM-A nrPDB 77 2e-14 2YJN-B nrPDB 57 1e-08 5L9W-B nrPDB 32 0.64 4YXC-B nrPDB 32 0.86 4YXB-D nrPDB 31 0.94 5U4N-A nrPDB 30 2.7 5U1D-B nrPDB 29 6.0 >2HI4-A nrPDB Length = 495 Score = 615 bits (1585), Expect = e-176, Method: Composition-based stats. Identities = 489/490 (99%), Positives = 489/490 (99%), Gaps = 1/490 (0%) Query: 27 VLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVL 86 VLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVL Sbjct: 3 VLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVL 62 Query: 87 VLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNT 146 VLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNT Sbjct: 63 VLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNT 122 Query: 147 FSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFG 206 FSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFG Sbjct: 123 FSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFG 182 Query: 207 QHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQK 266 QHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQK Sbjct: 183 QHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQK 242 Query: 267 TVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAI 326 TVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAI Sbjct: 243 TVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAI 302 Query: 327 SWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTI 386 SWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTI Sbjct: 303 SWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTI 362 Query: 387 PHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSE 446 PHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSE Sbjct: 363 PHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSE 422 Query: 447 KMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEH 506 KMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEH Sbjct: 423 KMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEH 482 Query: 507 VQARLRFSIN 516 VQAR RFSIN Sbjct: 483 VQAR-RFSIN 491 >6DWN-A nrPDB Length = 491 Score = 553 bits (1425), Expect = e-158, Method: Composition-based stats. Identities = 350/478 (73%), Positives = 406/478 (84%), Gaps = 3/478 (0%) Query: 37 KGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQ 96 KGLK+PP PWGWPL+GH+LTLGKNPHLALSRMSQ+YGDVLQIRIGSTPV+VLS LDTIRQ Sbjct: 8 KGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ 67 Query: 97 ALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASS 156 ALVRQGDDFKGRPDLYT TLI++GQS++FS DSGPVWAARRRLAQN L +FSIASDPASS Sbjct: 68 ALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASS 127 Query: 157 SSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEM 216 +SCYLEEHVSKEA+ LIS LQELMAGPGHF+PY VVVSV NVI A+CFG+ + + E+ Sbjct: 128 TSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQEL 187 Query: 217 LSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFD 276 LSLV + F E SGNP DF PILRYLPNP+L FK N++F F+QK V+EHY+ F+ Sbjct: 188 LSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFE 247 Query: 277 KNSVRDITGALFKHSKKGP--RASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLV 334 K +RDIT +L +H ++ + + EKI+N+V D+FGAGFDTVTTAISWSLMYLV Sbjct: 248 KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 307 Query: 335 TKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDT 394 P +QRKIQ+ELDTVIGR RRPRLSDR LPY+EAFILETFRHSSF+PFTIPHSTTRDT Sbjct: 308 MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDT 367 Query: 395 TLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMG 454 +L GFYIPK CVFVNQWQ+NHD +LW +PSEF PERFLT DG AI+K LSEK+++FGMG Sbjct: 368 SLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG-AIDKVLSEKVIIFGMG 426 Query: 455 KRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLR 512 KR+CIGE +A+WE+FLFLAILLQ++EFSVP GVKVD+TPIYGLTMKHA CEH Q +LR Sbjct: 427 KRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLR 484 >6B82-A nrPDB Length = 509 Score = 471 bits (1213), Expect = e-133, Method: Composition-based stats. Identities = 151/476 (31%), Positives = 249/476 (52%), Gaps = 17/476 (3%) Query: 35 VPKGLKSPPEPWGWPLLGHVLTLGKN--PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLD 92 VP G +SPP P++G +++L + PH+ + ++YGD+ + +GS +L+++ Sbjct: 18 VPAGNRSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHH 77 Query: 93 TIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASD 152 ++ L+++G F GRP T+ L+T D W R++ AL F S Sbjct: 78 HAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGEGS- 136 Query: 153 PASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPES 212 +E+ + +EA ++ L E D ++ +V NV+ A+CF + Sbjct: 137 ------VSIEKIICREASSMCEVLTESQNSA--VDLGPELTRAVTNVVCALCFNSSYKRG 188 Query: 213 SDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHY 272 E S+++ + V+T + + +D FP L+ PN L+ + LQK +EH Sbjct: 189 DAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLRILRQCISIRDKLLQKKYEEHK 248 Query: 273 QDFDKNSVRDITGALFKHSKKGPRASGNL----IPQEKIVNLVNDIFGAGFDTVTTAISW 328 + N RD+ AL + + + + + ++ ++ V +IFGAG +T TT + W Sbjct: 249 VTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTTLKW 308 Query: 329 SLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPH 388 S+ YLV P++QRKIQ+ELD+ IG+ER P+LSDR LPYLEA I E R P IPH Sbjct: 309 SIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIPH 368 Query: 389 STTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKM 448 +D+++ + + K V +N W ++HD + W++P F P RFL +G + P S Sbjct: 369 VALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCP-SGSY 427 Query: 449 MLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKV-DLTPIYGLTMKHAR 503 + FG G R C+GE LAK E+FLFLA +LQ+ +P G + DL +G+ ++ + Sbjct: 428 LPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKK 483 >2NNH-A nrPDB Length = 476 Score = 460 bits (1183), Expect = e-130, Method: Composition-based stats. Identities = 133/453 (29%), Positives = 216/453 (47%), Gaps = 19/453 (4%) Query: 40 KSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 K PP P P++G++L + K+ + + S+ YG V + G P++V + +++AL Sbjct: 10 KLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEAL 69 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 + G++F GR + S IT G + S +G W RR + L F + Sbjct: 70 IDNGEEFSGRGNSPISQRITKGLGIISS--NGKRWKEIRRFSLTTLRNFGMGKRS----- 122 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218 +E+ V +EA L+ L++ A P DP + + NVI ++ F + F L+ Sbjct: 123 --IEDRVQEEAHCLVEELRKTKASPC--DPTFILGCAPCNVICSVVFQKRFDYKDQNFLT 178 Query: 219 LVKNTHEFVETASSG--NPLDFFPILRY-LPNPALQRFKAFNQRFLWFLQKTVQEHYQDF 275 L+K +E +S + FP+L P + K ++++ V+EH Sbjct: 179 LMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNV-ALTRSYIREKVKEHQASL 237 Query: 276 DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 335 D N+ RD ++ + E +V V D+F AG +T +T + + L+ L+ Sbjct: 238 DVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLK 297 Query: 336 KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTT 395 PE+ K+Q+E+D VIGR R P + DR +PY +A + E R+S +P +PH+ T DT Sbjct: 298 HPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTK 357 Query: 396 LNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK 455 + IPK + V HD + + +P+ F P FL +G N S+ M F GK Sbjct: 358 FRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNG---NFKKSDYFMPFSAGK 414 Query: 456 RRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVK 488 R C GE LA+ E+FLFL +LQ +K Sbjct: 415 RICAGEGLARMELFLFLTTILQNFNLKSVDDLK 447 >5W0C-A nrPDB Length = 477 Score = 458 bits (1178), Expect = e-129, Method: Composition-based stats. Identities = 138/460 (30%), Positives = 229/460 (49%), Gaps = 20/460 (4%) Query: 40 KSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 K PP P P++G++L +G K+ +L+ +S+ YG V + G P++VL + +++AL Sbjct: 11 KLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEAL 70 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 + G++F GR + G + FS +G W RR + L F + Sbjct: 71 IDLGEEFSGRGIFPLAERANRGFGIVFS--NGKKWKEIRRFSLMTLRNFGMGKRS----- 123 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218 +E+ V +EA+ L+ L++ A P DP + + NVI ++ F + F + L+ Sbjct: 124 --IEDRVQEEARCLVEELRKTKASPC--DPTFILGCAPCNVICSIIFHKRFDYKDQQFLN 179 Query: 219 LVKNTHEFVETASSGNPL---DFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF 275 L++ +E ++ SS +F PI+ Y P + K + L+K V+EH + Sbjct: 180 LMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEK-VKEHQESM 238 Query: 276 DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 335 D N+ +D +K + E + N D+FGAG +T +T + ++L+ L+ Sbjct: 239 DMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLK 298 Query: 336 KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTT 395 PE+ K+Q+E++ VIGR R P + DR +PY +A + E R+ LP ++PH+ T D Sbjct: 299 HPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIK 358 Query: 396 LNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK 455 + IPK + ++ V HD + + +P F P FL G N S+ M F GK Sbjct: 359 FRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGG---NFKKSKYFMPFSAGK 415 Query: 456 RRCIGEVLAKWEIFLFLAILLQQLEF-SVPPGVKVDLTPI 494 R C+GE LA E+FLFL +LQ S+ +D TP+ Sbjct: 416 RICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPV 455 >4GQS-A nrPDB Length = 477 Score = 456 bits (1172), Expect = e-128, Method: Composition-based stats. Identities = 133/460 (28%), Positives = 224/460 (48%), Gaps = 20/460 (4%) Query: 40 KSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 K PP P P++G++L + K+ +L+ +S+ YG V + G ++VL + +++AL Sbjct: 11 KLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEAL 70 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 + G++F GR + G + FS +G W RR + L F + Sbjct: 71 IDLGEEFSGRGHFPLAERANRGFGIVFS--NGKRWKEIRRFSLMTLRNFGMGKRS----- 123 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218 +E+ V +EA+ L+ L++ A P DP + + NVI ++ F + F + L+ Sbjct: 124 --IEDRVQEEARCLVEELRKTKASPC--DPTFILGCAPCNVICSIIFQKRFDYKDQQFLN 179 Query: 219 LVKNTHEFVETASSG--NPLDFFP-ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF 275 L++ +E + S+ + FP I+ Y P + K L+K V+EH + Sbjct: 180 LMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK-VKEHQESM 238 Query: 276 DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 335 D N+ RD +K + + E +V D+ GAG +T +T + ++L+ L+ Sbjct: 239 DINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLK 298 Query: 336 KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTT 395 PE+ K+Q+E++ V+GR R P + DR +PY +A + E R+ +P ++PH+ T D Sbjct: 299 HPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVK 358 Query: 396 LNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK 455 + IPK + + V HD + + +P F P FL G N S M F GK Sbjct: 359 FRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGG---NFKKSNYFMPFSAGK 415 Query: 456 RRCIGEVLAKWEIFLFLAILLQQLEF-SVPPGVKVDLTPI 494 R C+GE LA+ E+FLFL +LQ S+ +D TP+ Sbjct: 416 RICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPV 455 >1N6B-A nrPDB Length = 473 Score = 447 bits (1149), Expect = e-126, Method: Composition-based stats. Identities = 139/460 (30%), Positives = 231/460 (50%), Gaps = 23/460 (5%) Query: 40 KSPPEPWGWPLLGHVLTL-GKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 K PP P +P++G++L + K+ +L++ S+ YG V + +G P +VL + +++AL Sbjct: 10 KLPPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLHGYEAVKEAL 69 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 V G++F GR + ++ G + FS + W RR + L F + Sbjct: 70 VDLGEEFAGRGSVPILEKVSKGLGIAFS--NAKTWKEMRRFSLMTLRNFGMGKRS----- 122 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218 +E+ + +EA+ L+ L++ A P DP + + NVI ++ F F +E L Sbjct: 123 --IEDRIQEEARCLVEELRKTNASPC--DPTFILGCAPCNVICSVIFHNRFDYKDEEFLK 178 Query: 219 LVKNTHEFVETASSG--NPLDFFP-ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF 275 L+++ HE VE + + FP +L Y P K + F+ + V+EH + Sbjct: 179 LMESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADY-IKNFIMEKVKEHQKLL 237 Query: 276 DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 335 D N+ RD ++ E +V V+D+FGAG +T +T + +SL+ L+ Sbjct: 238 DVNNPRDFIDCFLIKMEQENNLE---FTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLK 294 Query: 336 KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTT 395 PE+ ++Q+E++ VIGR R P + DR ++PY +A I E R LP +PH+ TRD Sbjct: 295 HPEVAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVR 354 Query: 396 LNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK 455 ++IPK + + V HD + + +P F P FL G N S+ M F GK Sbjct: 355 FRNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESG---NFKKSDYFMPFSAGK 411 Query: 456 RRCIGEVLAKWEIFLFLAILLQQLEF-SVPPGVKVDLTPI 494 R C+GE LA+ E+FLFL +LQ + S+ +D+T + Sbjct: 412 RMCVGEGLARMELFLFLTSILQNFKLQSLVEPKDLDITAV 451 >4H1N-A nrPDB Length = 479 Score = 435 bits (1119), Expect = e-122, Method: Composition-based stats. Identities = 138/461 (29%), Positives = 222/461 (48%), Gaps = 20/461 (4%) Query: 40 KSPPEPWGWPLLGHVLTLGKNPHL-ALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 K PP P P+LG++L + + L + R+ ++YGDV + +GS PV+VL D IR+AL Sbjct: 10 KLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLCGTDAIREAL 69 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 V Q + F GR + I G + F+ +G W A RR + + F + Sbjct: 70 VDQAEAFSGRGKIAVVDPIFQGYGVIFA--NGERWRALRRFSLATMRDFGMGKRS----- 122 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218 +EE + +EA+ L+ L++ D +N+I ++ FG+ F L Sbjct: 123 --VEERIQEEARCLVEELRKSKG--ALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLR 178 Query: 219 LVKNTHEFVETASSGN---PLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF 275 L+ + SS + F L+Y P Q ++ Q F+ ++V++H Sbjct: 179 LLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNL-QEINTFIGQSVEKHRATL 237 Query: 276 DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 335 D ++ RD +K + + ++ V +F AG +T +T + + + ++ Sbjct: 238 DPSNPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLK 297 Query: 336 KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTT 395 P + ++QKE++ VIG R P L DR ++PY +A I E R +PF +PH+ T+DT Sbjct: 298 YPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQ 357 Query: 396 LNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK 455 G+ IPK VF HDP +E P+ F P FL A+G +E M F +GK Sbjct: 358 FRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGAL---KRNEGFMPFSLGK 414 Query: 456 RRCIGEVLAKWEIFLFLAILLQQLEFSVP-PGVKVDLTPIY 495 R C+GE +A+ E+FLF +LQ + P P +DLTP Sbjct: 415 RICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPRE 455 >3E6I-A nrPDB Length = 476 Score = 433 bits (1112), Expect = e-121, Method: Composition-based stats. Identities = 143/470 (30%), Positives = 232/470 (49%), Gaps = 22/470 (4%) Query: 40 KSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 K PP P+ P++G++ L KN + +R++QR+G V + +GS ++V+ +++AL Sbjct: 10 KLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEAL 69 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 + D+F GR DL D + + F ++GP W RR + L + + Sbjct: 70 LDYKDEFSGRGDLPAFHAHRD-RGIIF--NNGPTWKDIRRFSLTTLRNYGMGKQGN---- 122 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218 E + +EA L+ L++ P FDP + + NVI + F +HF + ++ L Sbjct: 123 ---ESRIQREAHFLLEALRKTQGQP--FDPTFLIGCAPCNVIADILFRKHFDYNDEKFLR 177 Query: 219 LVKNTHEFVETASSG--NPLDFFP-ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF 275 L+ +E S+ + FP L YLP + K ++ + V+EH+Q Sbjct: 178 LMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNV-AEVKEYVSERVKEHHQSL 236 Query: 276 DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 335 D N RD+T L +K ++ L + I V D+F AG +T +T + + L+ L+ Sbjct: 237 DPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMK 296 Query: 336 KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTT 395 PEI+ K+ +E+D VIG R P + DR ++PY++A + E R + +P +PH TRDT Sbjct: 297 YPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTI 356 Query: 396 LNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK 455 G+ IPK V V +D + + DP +F+PE FL +G S+ F GK Sbjct: 357 FRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKF---KYSDYFKPFSTGK 413 Query: 456 RRCIGEVLAKWEIFLFLAILLQQLEFS-VPPGVKVDLTPIY-GLTMKHAR 503 R C GE LA+ E+FL L +LQ + +DL+PI+ G R Sbjct: 414 RVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPR 463 >2PG7-A nrPDB Length = 476 Score = 425 bits (1092), Expect = e-119, Method: Composition-based stats. Identities = 135/461 (29%), Positives = 224/461 (48%), Gaps = 20/461 (4%) Query: 40 KSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 K PP P P +G+ L L + + +L ++S+RYG V I +G V+VL D +R+AL Sbjct: 10 KLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREAL 69 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 V Q ++F GR + T + G + FS +G RR + L F + Sbjct: 70 VDQAEEFSGRGEQATFDWVFKGYGVVFS--NGERAKQLRRFSIATLRDFGVGKRG----- 122 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218 +EE + +EA LI L+ G + DP + +V+NVI ++ FG F E LS Sbjct: 123 --IEERIQEEAGFLIDALRGT--GGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLS 178 Query: 219 LVK---NTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF 275 L++ +F T++ F ++++LP P Q F Q F+ K V+ + + Sbjct: 179 LLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAF-QLLQGLEDFIAKKVEHNQRTL 237 Query: 276 DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 335 D NS RD + ++ + + +V +F G +TV+T + + + L+ Sbjct: 238 DPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMK 297 Query: 336 KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTT 395 PE++ K+ +E+D VIG+ R+P+ DR ++PY+EA I E R +P ++ +DT Sbjct: 298 HPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTK 357 Query: 396 LNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK 455 F++PK V+ V DP + +P +F P+ FL G S+ + F +GK Sbjct: 358 FRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQF---KKSDAFVPFSIGK 414 Query: 456 RRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVK-VDLTPIY 495 R C GE LA+ E+FLF ++Q K +D++P + Sbjct: 415 RNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKH 455 >5E58-A nrPDB Length = 493 Score = 419 bits (1077), Expect = e-117, Method: Composition-based stats. Identities = 129/465 (27%), Positives = 214/465 (46%), Gaps = 20/465 (4%) Query: 53 HVLTLGKNPHL-ALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDL 111 ++L + + L + R+ ++YGDV + +G PV++L + IR+ALV Q + F GR + Sbjct: 42 NLLQMDRGGFLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 101 Query: 112 YTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKA 171 + + FS +G W RR + + F + +E+ + +EA+ Sbjct: 102 AVIKPVIGDYGMIFS--NGERWKVLRRFSLATMRDFGMGKRS-------VEDRIQEEAQC 152 Query: 172 LISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNT---HEFVE 228 L+ LQ+ P DP AN+I ++ FG+ + + L L+ + Sbjct: 153 LVEELQKSQGAP--LDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMS 210 Query: 229 TASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALF 288 + SS F ++Y P Q + Q L ++ ++V++H D ++ RD Sbjct: 211 SFSSQVFELFSGFMKYFPGAHRQITRNL-QEILDYVGQSVEKHRATLDPSNPRDFIDTYL 269 Query: 289 KHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELD 348 +K + ++ V +F AG +T +T + + + ++ P + K+QKE+D Sbjct: 270 LRMEKEKSNQHTEFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEID 329 Query: 349 TVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVF 408 VIG R P L DR ++PY +A I E R S P PH T+DT G+ +PK V+ Sbjct: 330 QVIGSHRLPTLEDRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVY 389 Query: 409 VNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEI 468 HDP+ +E P F P+ FL A+G SE M F +GKR C+GE +A+ E+ Sbjct: 390 PILSSALHDPQYFEQPGTFNPDHFLDANGAL---KKSEAFMPFSIGKRICLGEGIARNEL 446 Query: 469 FLFLAILLQQLEFSVPPGVK-VDLTPIYGLTMKHARCEHVQARLR 512 FLF +LQ S K +DL+P K + + R Sbjct: 447 FLFFTTILQNFSVSSSVAPKDIDLSPKESGIGKVPQTYQISFLAR 491 >5E0E-A nrPDB Length = 463 Score = 419 bits (1076), Expect = e-117, Method: Composition-based stats. Identities = 133/448 (29%), Positives = 214/448 (47%), Gaps = 20/448 (4%) Query: 53 HVLTLGKNPHL-ALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDL 111 ++L + + L + R+ ++YGDV + +G PV++L + IR+ALV Q + F GR + Sbjct: 14 NLLQMDRGGFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 73 Query: 112 YTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKA 171 I G + F+ +G W A RR + + F + +EE + +EA+ Sbjct: 74 AVVEPIFRGYGVVFA--NGERWKALRRFSLVTMRDFGMGKRS-------VEERIQEEARC 124 Query: 172 LISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETAS 231 L+ ++ P DP AN+I ++ FG+ F + L L+ ++ S Sbjct: 125 LVEEFRKSQGAP--LDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLIS 182 Query: 232 SGN---PLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALF 288 S + F L+Y P Q + Q L ++ ++V++H D + RD Sbjct: 183 SFSSQVFELFSGFLKYFPGTHRQISRNL-QEILDYIGQSVEKHRATLDPSHPRDFIDTYL 241 Query: 289 KHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELD 348 +K + +V V +F AG +T +T + + + ++ P + K+QKE+D Sbjct: 242 LRMEKEKSNQHTEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEID 301 Query: 349 TVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVF 408 VIG R P L DR ++PY EA I E R S +P +PH T+DT G+ +PK V+ Sbjct: 302 QVIGSHRLPTLEDRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVY 361 Query: 409 VNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEI 468 HDP+ +E P F P+ FL A+G SE M F +GKR C+GE +A+ E+ Sbjct: 362 PILSSALHDPQYFEQPDTFNPDHFLDANGAL---KKSEAFMPFSIGKRICLGEGIARNEL 418 Query: 469 FLFLAILLQQLEFSVPPGVK-VDLTPIY 495 FLF +LQ S P K +DL+P Sbjct: 419 FLFFTTILQNFSLSSPVAPKDIDLSPKE 446 >4R1Z-A nrPDB Length = 439 Score = 416 bits (1069), Expect = e-116, Method: Composition-based stats. Identities = 138/429 (32%), Positives = 221/429 (51%), Gaps = 15/429 (3%) Query: 80 IGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRL 139 +GS +L+++ ++ L+++G F GRP T+ L+T D W R++ Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKM 60 Query: 140 AQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANV 199 AL F S +E+ + +EA ++ L E D ++ +V NV Sbjct: 61 VHGALCMFGEGS-------VSIEKIICREASSMCEVLTESQNSA--VDLGPELTRAVTNV 111 Query: 200 IGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQR 259 + A+CF + E S+++ + V+T + + +D FP L+ PN L + Sbjct: 112 VCALCFNSSYKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLTILRQCISI 171 Query: 260 FLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNL----IPQEKIVNLVNDIF 315 LQK +EH + N RD+ AL + + + + + ++ ++ V DIF Sbjct: 172 RDKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIF 231 Query: 316 GAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILET 375 GAG +T TT + WS+ YLV P++QRKIQ+ELD+ IG+ER P+LSDR LPYLEA I E Sbjct: 232 GAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREV 291 Query: 376 FRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTA 435 R P IPH +D+++ + + K V +N W ++HD + W++P F P RFL Sbjct: 292 LRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNE 351 Query: 436 DGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKV-DLTPI 494 +G + P S + FG G R C+GE LAK E+FLFLA +LQ+ +P G + DL Sbjct: 352 EGDGLCCP-SGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGK 410 Query: 495 YGLTMKHAR 503 +G+ ++ + Sbjct: 411 FGVVLQPKK 419 >4R20-A nrPDB Length = 486 Score = 413 bits (1061), Expect = e-116, Method: Composition-based stats. Identities = 143/444 (32%), Positives = 228/444 (51%), Gaps = 14/444 (3%) Query: 61 PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG 120 PHL +++S +YG + + G LV+S + +R+ L+++G +F GRP + T+ L+T G Sbjct: 41 PHLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQG 100 Query: 121 QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM 180 D P+W RRL ++ F S+ L+ V + A +L LQ Sbjct: 101 GKDIAFADYSPLWKNHRRLVHSSFTLFGEGSN-------KLQTIVQEAADSLCEELQACR 153 Query: 181 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP 240 D ++ +V NVI + F + S E+ ++++ V+T + G +D FP Sbjct: 154 GQ--SSDLSVVLMRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIFP 211 Query: 241 ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN 300 LR PN L+R K L K + EH + RD+ AL ++G + + Sbjct: 212 WLRIFPNKDLKRLKECVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALLIGQQRGSGGADD 271 Query: 301 LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS 360 I ++ ++ + FGAG +T +T + W++ +L+ P++Q ++Q ELD +G +R P LS Sbjct: 272 -ITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLS 330 Query: 361 DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL 420 DRP LP L+A + E R P IPH +DT+L G +PK V VN W ++HDP+ Sbjct: 331 DRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKH 390 Query: 421 WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480 W+ P +F PERFL G K + FG G R C+GE LA+ E+FLF++ LQ+ Sbjct: 391 WDQPEQFNPERFLEPSGK---KKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFS 447 Query: 481 FSVPPGVKV-DLTPIYGLTMKHAR 503 FS P + DL +G+ ++ R Sbjct: 448 FSCPSEASLPDLQGRFGVVLQPER 471 >3IBD-A nrPDB Length = 476 Score = 411 bits (1056), Expect = e-115, Method: Composition-based stats. Identities = 124/446 (27%), Positives = 213/446 (47%), Gaps = 20/446 (4%) Query: 53 HVLTL-GKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDL 111 ++L + + + R ++YGDV + +G PV++L ++ IR+ALV + + F GR + Sbjct: 23 NLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKI 82 Query: 112 YTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKA 171 G + F+ +G W RR + + F + +EE + +EA+ Sbjct: 83 AMVDPFFRGYGVIFA--NGNRWKVLRRFSVTTMRDFGMGKRS-------VEERIQEEAQC 133 Query: 172 LISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETAS 231 LI L++ DP AN+I ++ FG+ F E L ++ ++ S Sbjct: 134 LIEELRKSKG--ALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLIS 191 Query: 232 S--GNPLDFFP-ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALF 288 S G + F L++ P Q +K Q ++ +V++H + D ++ RD+ Sbjct: 192 SVFGQLFELFSGFLKHFPGAHRQVYKNL-QEINAYIGHSVEKHRETLDPSAPRDLIDTYL 250 Query: 289 KHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELD 348 H +K + + + + +F AG +T +T + + + ++ P + ++ +E++ Sbjct: 251 LHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIE 310 Query: 349 TVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVF 408 VIG R P L DR ++PY EA I E R S LP +PH T+ T+ G+ IPK VF Sbjct: 311 QVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVF 370 Query: 409 VNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEI 468 + HDP +E P F P+ FL A+G +E + F +GKR C+GE +A+ E+ Sbjct: 371 LILSTALHDPHYFEKPDAFNPDHFLDANGAL---KKTEAFIPFSLGKRICLGEGIARAEL 427 Query: 469 FLFLAILLQQLEFSVPP-GVKVDLTP 493 FLF +LQ + P +DLTP Sbjct: 428 FLFFTTILQNFSMASPVAPEDIDLTP 453 >5UYS-A nrPDB Length = 494 Score = 408 bits (1049), Expect = e-114, Method: Composition-based stats. Identities = 136/471 (28%), Positives = 229/471 (48%), Gaps = 19/471 (4%) Query: 38 GLKSPPEPWGWPLLGHVLTLGKNPHLA--LSRMSQRYGDVLQIRIGSTPVLVLSRLDTIR 95 G K P PL+G + L ++ H+ ++ ++YG + +R+G+ +++ + Sbjct: 6 GAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAK 65 Query: 96 QALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPAS 155 + L+++G DF GRP + T + ++ + DSG W RRL A+ TF++ D Sbjct: 66 EVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRL---AMATFALFKD--- 119 Query: 156 SSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDE 215 LE+ + +E L L D V V+V NVI +CF + E Sbjct: 120 -GDQKLEKIICQEISTLCDMLATHNGQ--SIDISFPVFVAVTNVISLICFNTSYKNGDPE 176 Query: 216 MLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF 275 + + ++ S + +D P L+ PN L++ K+ + L K ++ + + F Sbjct: 177 LNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKF 236 Query: 276 DKNSVRDITGALFKHS------KKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWS 329 +S+ ++ L + GP L+ I+ + DIFGAG +T T+ + W+ Sbjct: 237 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 296 Query: 330 LMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHS 389 L +L+ P++++K+ +E+D +G R P +SDR +L LEA I E R P IPH Sbjct: 297 LAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHK 356 Query: 390 TTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMM 449 D+++ F + K V +N W ++H+ + W P +F PERFL GT + P S + Sbjct: 357 ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISP-SVSYL 415 Query: 450 LFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVP-PGVKVDLTPIYGLTM 499 FG G R CIGE+LA+ E+FL +A LLQ+ + VP G L I + Sbjct: 416 PFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVF 466 >6IQ5-A nrPDB Length = 463 Score = 399 bits (1026), Expect = e-111, Method: Composition-based stats. Identities = 177/448 (39%), Positives = 255/448 (56%), Gaps = 13/448 (2%) Query: 62 HLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQ 121 HL+ +R+++RYGDV QIR+GS P++VL+ I QALV+QG F RP + +++ G+ Sbjct: 4 HLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGR 63 Query: 122 SLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMA 181 S+ F W +RR A + + F P S LE HV EA+ L++ L A Sbjct: 64 SMAFGH-YSEHWKVQRRAAHSMMRNF-FTRQPRSRQV--LEGHVLSEARELVALLVRGSA 119 Query: 182 GPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPI 241 DP VV+VANV+ A+CFG + E L+ + EF T +G+ +D P Sbjct: 120 DGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPW 179 Query: 242 LRYLPNPALQRFKAF---NQRFLWFLQKTVQEHYQDFDKNS-VRDITGALFKHSKK---- 293 L+Y PNP F+ F N+ F F+ H + + RD+ A ++K Sbjct: 180 LQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAG 239 Query: 294 GPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGR 353 G + E + + DIFGA DT++TA+ W L+ P++Q ++Q ELD V+GR Sbjct: 240 DSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGR 299 Query: 354 ERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQ 413 +R P + D+P LPY+ AF+ E R SSF+P TIPH+TT +T++ G++IPK VFVNQW Sbjct: 300 DRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWS 359 Query: 414 VNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLA 473 VNHDP W +P F P RFL DG INK L+ ++M+F +GKRRCIGE L+K ++FLF++ Sbjct: 360 VNHDPVKWPNPENFDPARFLDKDG-LINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFIS 418 Query: 474 ILLQQLEFSVPPGVKVDLTPIYGLTMKH 501 IL Q +F P + YGLT+K Sbjct: 419 ILAHQCDFRANPNEPAKMNFSYGLTIKP 446 >3DL9-A nrPDB Length = 479 Score = 392 bits (1006), Expect = e-109, Method: Composition-based stats. Identities = 121/443 (27%), Positives = 209/443 (47%), Gaps = 15/443 (3%) Query: 61 PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG 120 PH+ + + SQ YG++ + +G +VL+ D +++ LV Q + F RP L +T Sbjct: 36 PHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM 95 Query: 121 QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM 180 L ++ G W RRLA N+ F E + +E K ++ Sbjct: 96 GGL-LNSRYGRGWVDHRRLAVNSFRYFGYGQKS-------FESKILEETKFFNDAIETYK 147 Query: 181 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPL--DF 238 P FD + +V+N+ + FG+ F + +++ E VE A+S + + Sbjct: 148 GRP--FDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNA 205 Query: 239 FPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRAS 298 FP + LP Q+ FL + +++ + + A +G Sbjct: 206 FPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDP 265 Query: 299 GNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPR 358 + +E ++ V ++ AG +T T + W+++++ P IQ ++QKE+D ++G +P Sbjct: 266 SSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS 325 Query: 359 LSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDP 418 D+ ++PY EA + E R + +P I H+T+ D + G+ IPK V N + V+ D Sbjct: 326 WDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDE 385 Query: 419 ELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQ 478 + W DP F PERFL + G K E ++ F +G+R C+GE LA+ E+FLF LLQ+ Sbjct: 386 KYWRDPEVFHPERFLDSSGYFAKK---EALVPFSLGRRHCLGEHLARMEMFLFFTALLQR 442 Query: 479 LEFSVPPGVKVDLTPIYGLTMKH 501 P + DL P G+T++ Sbjct: 443 FHLHFPHELVPDLKPRLGMTLQP 465 >5YLW-A nrPDB Length = 495 Score = 386 bits (991), Expect = e-107, Method: Composition-based stats. Identities = 125/484 (25%), Positives = 209/484 (43%), Gaps = 24/484 (4%) Query: 6 SVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLAL 65 S P A +A+ I L F + L PP P+ +P++G++L LG NPH Sbjct: 3 SFPLLAALFFIAATITFLSFRRRRNL----------PPGPFPYPIVGNMLQLGANPHQVF 52 Query: 66 SRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTF 125 +++S+RYG ++ I +GS +++S + ++ L R G F GR + + D ++ Sbjct: 53 AKLSKRYGPLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGR-TIAQAVHACDHDKISM 111 Query: 126 S-TDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPG 184 W R++ + + FS S AS ++ + L+ +Q+ Sbjct: 112 GFLPVASEWRDMRKICKEQM--FSNQSMEASQGLR------RQKLQQLLDHVQKCSDSGR 163 Query: 185 HFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVET-ASSGNPLDFFPILR 243 D ++ N++ A F E + K E V T N D+FPILR Sbjct: 164 AVDIREAAFITTLNLMSATLFSSQATEFDSKATMEFKEIIEGVATIVGVPNFADYFPILR 223 Query: 244 YL-PNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLI 302 P +R F + L ++ + E + N + +A+ + Sbjct: 224 PFDPQGVKRRADVFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQANEFKL 283 Query: 303 PQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDR 362 +L+ D+F G DT TT+I W++ LV P+ +++ EL +V G E+ S Sbjct: 284 KTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDESAM 343 Query: 363 PQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWE 422 P+LPYL+A I E R P +P D +NG+ IPK + +N + + DP +W Sbjct: 344 PKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSIWT 403 Query: 423 DPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482 DP F PERFL K +++ FG G+R C G LA + + A L+ ++ Sbjct: 404 DPETFDPERFLDNKIDF--KGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNFDWK 461 Query: 483 VPPG 486 + Sbjct: 462 LEDD 465 >3TBG-A nrPDB Length = 479 Score = 378 bits (971), Expect = e-105, Method: Composition-based stats. Identities = 136/435 (31%), Positives = 214/435 (49%), Gaps = 18/435 (4%) Query: 59 KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLIT 118 +N ++ +R+GDV +++ TPV+VL+ L +R+ALV G+D RP + + ++ Sbjct: 30 QNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILG 89 Query: 119 DG--QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRL 176 G F GP W +RR + + L + LE+ V++EA L + Sbjct: 90 FGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKS-------LEQWVTEEAACLCAAF 142 Query: 177 QELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSG--N 234 P F P + +V+NVI ++ G+ F L L+ E ++ S Sbjct: 143 ANHSGRP--FRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLRE 200 Query: 235 PLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDK-NSVRDITGALFKHSKK 293 L+ P+L ++P A + + F + FL L + + EH +D RD+T A +K Sbjct: 201 VLNAVPVLLHIPALAGKVLR-FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEK 259 Query: 294 GPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGR 353 + E + +V D+F AG T +T ++W L+ ++ P++QR++Q+E+D VIG+ Sbjct: 260 AKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQ 319 Query: 354 ERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQ 413 RRP + D+ +PY A I E R +P + H T+RD + GF IPK + N Sbjct: 320 VRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSS 379 Query: 414 VNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLA 473 V D +WE P F PE FL A G + E + F G+R C+GE LA+ E+FLF Sbjct: 380 VLKDEAVWEKPFRFHPEHFLDAQGHFVK---PEAFLPFSAGRRACLGEPLARMELFLFFT 436 Query: 474 ILLQQLEFSVPPGVK 488 LLQ FSVP G Sbjct: 437 SLLQHFSFSVPTGQP 451 >5VBU-A nrPDB Length = 476 Score = 354 bits (908), Expect = 6e-98, Method: Composition-based stats. Identities = 121/466 (25%), Positives = 217/466 (46%), Gaps = 33/466 (7%) Query: 37 KGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQ 96 KG P P G + L + + L ++Q++G + ++ +G V+VL+ TI + Sbjct: 8 KGKLPPLAP------GFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEE 61 Query: 97 ALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASS 156 A+V++ DF GRP+ T L++ D +W A ++L ++AL Sbjct: 62 AMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLL---------G 112 Query: 157 SSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEM 216 +E V + + R++ P + + + ++I + FG + + M Sbjct: 113 IRDSMEPVVEQLTQEFCERMRAQPGTPVAIE--EEFSLLTCSIICYLTFGDKI-KDDNLM 169 Query: 217 LSLVKNTHEFVETAS--SGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQD 274 + K E ++T S S +D P LR+ PNP L+R K ++ ++ +++H + Sbjct: 170 PAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKES 229 Query: 275 FDKNSVRDITGALFKHSKKGPRASGN-LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYL 333 RD+ + + + G+ + + + D+ G +T +SW++++L Sbjct: 230 LVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFL 289 Query: 334 VTKPEIQRKIQKELDTVIGRER---RPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHST 390 + PEIQ+++Q+ELD +G R DR +LP L A I E R +P +PH T Sbjct: 290 LHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRT 349 Query: 391 TRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMML 450 TR ++++G+ IP+ + N + D +WE P EF P+RFL + + + Sbjct: 350 TRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEP-------GKNSRALA 402 Query: 451 FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKV-DLTPIY 495 FG G R C+GE LA+ E+F+ L LLQ +P G + L P+ Sbjct: 403 FGCGARVCLGEPLARLELFVVLTRLLQAFTL-LPSGDALPSLQPLP 447 >3QZ1-A nrPDB Length = 496 Score = 354 bits (907), Expect = 7e-98, Method: Composition-based stats. Identities = 132/499 (26%), Positives = 222/499 (44%), Gaps = 54/499 (10%) Query: 26 WVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPV 85 W L+ L PP G + L N + L ++Q+ G V ++R+G V Sbjct: 23 WKLRNLH--------LPPLVP-----GFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEV 69 Query: 86 LVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALN 145 +VL+ TI +A++R+ DF GRP + + L++ D +W A ++L ++AL Sbjct: 70 VVLNSKRTIEEAMIRKWVDFAGRPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSALL 129 Query: 146 TFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCF 205 + +S +E V + + R++ P + + ++I + F Sbjct: 130 LGTRSS---------MEPWVDQLTQEFCERMRVQAGAPVTI--QKEFSLLTCSIICYLTF 178 Query: 206 GQHFPESSDEMLSLVKNTHEFVETAS--SGNPLDFFPILRYLPNPALQRFKAFNQRFLWF 263 G + + + + ++T S LD P LR+ PNP L R K + Sbjct: 179 GN---KEDTLVHAFHDCVQDLMKTWDHWSIQILDMVPFLRFFPNPGLWRLKQAIENRDHM 235 Query: 264 LQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASG-NLIPQEKIVNLVNDIFGAGFDTV 322 ++K ++ H + RD+T + + + G + + + V D+F G +T Sbjct: 236 VEKQLRRHKESMVAGQWRDMTDYMLQGVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETT 295 Query: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRER---RPRLSDRPQLPYLEAFILETFRHS 379 + +SW++ +L+ PEIQR++Q+ELD +G R DR +LP L A I E R Sbjct: 296 ASTLSWAVAFLLHHPEIQRRLQEELDRELGPGASCSRVTYKDRARLPLLNATIAEVLRLR 355 Query: 380 SFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTA 439 +P +PH TTR +++ G+ IP+ V N + D +WE P EFRP+RFL Sbjct: 356 PVVPLALPHRTTRPSSIFGYDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANP 415 Query: 440 INKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPP-------------G 486 + FG G R C+GE LA+ E+F+ LA LLQ PP G Sbjct: 416 -------SALAFGCGARVCLGESLARLELFVVLARLLQAFTLLPPPVGALPSLQPDPYCG 468 Query: 487 VKVDLTPIYGLTMKHARCE 505 V + + P + + ++ E Sbjct: 469 VNLKVQP-FQVRLQPRGVE 486 >3JUS-A nrPDB Length = 461 Score = 323 bits (828), Expect = 1e-88, Method: Composition-based stats. Identities = 94/455 (20%), Positives = 172/455 (37%), Gaps = 32/455 (7%) Query: 35 VPKGLKSPPEPW-GWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDT 93 +P G+KSPP + P LGH + GK+P L ++YG V + L D Sbjct: 6 LPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDA 65 Query: 94 IRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDP 153 + +D T G+ + + + PV+ ++++ ++ L + Sbjct: 66 AALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPN-PVFLEQKKMLKSGL-NIAHFKQH 123 Query: 154 ASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESS 213 S + KE K E F+ +++++ A H Sbjct: 124 VS--------IIEKETKEYFESWGE-SGEKNVFEALSELIILTA---------SHCLHGK 165 Query: 214 DEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQ 273 + L + + G + + +LP P+ +R ++ K +Q+ Q Sbjct: 166 EIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQ 225 Query: 274 DFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYL 333 +K + DI L + K G + +++ ++ + AG T +T +W +L Sbjct: 226 SQEK--IDDILQTLLDATYK----DGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFL 279 Query: 334 VTKPEIQRKIQKELDTVIGRERRPRLSDRPQ-LPYLEAFILETFRHSSFLPFTIPHSTTR 392 +Q+K E TV G P D+ + L L+ I ET R + + Sbjct: 280 ARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPI-MIMMRMART 338 Query: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFG 452 T+ G+ IP V V+ + W + +F P+R+L + + K + FG Sbjct: 339 PQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEK---FAYVPFG 395 Query: 453 MGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV 487 G+ RCIGE A +I + +L+ EF + G Sbjct: 396 AGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGY 430 >6CR2-A nrPDB Length = 477 Score = 323 bits (827), Expect = 1e-88, Method: Composition-based stats. Identities = 91/475 (19%), Positives = 175/475 (36%), Gaps = 55/475 (11%) Query: 39 LKSPPEPWGW-PLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQA 97 K+PP + W P +G ++ G +P+ +YGD+ + V Sbjct: 3 KKTPPVVFHWFPFIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTV---------Y 53 Query: 98 LVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAAR--------RRLAQNALNTFSI 149 L +G+DF + L +S + PV+ + + Q + + Sbjct: 54 LGTKGNDF-----ILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKYGL 108 Query: 150 ASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHF 209 SD S + + E ++ + G FD + G+ Sbjct: 109 TSDALRSYVPLITD----EVESFVKNSPAFQGHKGVFDVCKTIAEITIYTASRSLQGKEV 164 Query: 210 PESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQ 269 D + + + P++F +L + P P ++ A ++ + ++ Sbjct: 165 RSKFDSTFAEL-----YHNLDMGFAPINF--MLPWAPLPHNRKRDAAQRKLTETYMEIIK 217 Query: 270 EHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWS 329 Q K D+ L K +G +P E+I +++ + AG + ++ SW Sbjct: 218 ARRQAGSKKDSEDMVWNLMSCVYK----NGTPVPDEEIAHMMIALLMAGQHSSSSTASWI 273 Query: 330 LMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEA-FILETFRHSSFLPFTIPH 388 ++ L T+P+I ++ +E V+G + P D Q L A I ET R + + +I Sbjct: 274 VLRLATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPI-HSIIR 332 Query: 389 STTRDTTLNG--FYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTA------- 439 + ++G + IP V + E + +P E+ P R+ + Sbjct: 333 AVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKV 392 Query: 440 ------INKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVK 488 ++K + + FG G+ RCIGE A ++ A+L++ F PGV Sbjct: 393 DYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPGVD 447 >5FSA-A nrPDB Length = 490 Score = 315 bits (807), Expect = 3e-86, Method: Composition-based stats. Identities = 93/475 (19%), Positives = 164/475 (34%), Gaps = 43/475 (9%) Query: 39 LKSPPEPWGW-PLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQA 97 K+PP + W P G + G+ P+ Q+YGDV + + V Sbjct: 3 KKTPPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFV 62 Query: 98 LVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSS 157 + D T G + + + R + Q F++ +D Sbjct: 63 FNAKLSDVSAEEAYKHLTTPVFGTGVIYDCPNS------RLMEQKKFAKFALTTDSFKRY 116 Query: 158 SCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEML 217 + E + + G + FG D Sbjct: 117 VPKIREEILNYFVTD-ESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSF 175 Query: 218 SLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDK 277 + + + + P++F LP P R A ++ K ++ + D Sbjct: 176 AQLYS-----DLDKGFTPINFV--FPNLPLPHYWRRDAAQKKISATYMKEIKLRRERGDI 228 Query: 278 NSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKP 337 + RD+ +L HS G + ++I NL+ I G T + +W L++L KP Sbjct: 229 DPNRDLIDSLLIHS---TYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKP 285 Query: 338 EIQRKIQKELDTVI----GRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRD 393 +Q I +E+ ++ G D +LP + I ET R L +I T Sbjct: 286 HLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPL-HSIFRKVTNP 344 Query: 394 TTL--NGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTA------------ 439 + + +PK V V+ + +++P +F P R+ TA A Sbjct: 345 LRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVD 404 Query: 440 -----INKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKV 489 ++K +S + FG G+ RCIGE A ++ L + L +++ G KV Sbjct: 405 YGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTI-DGYKV 458 >6DA2-A nrPDB Length = 487 Score = 308 bits (790), Expect = 2e-84, Method: Composition-based stats. Identities = 99/475 (20%), Positives = 184/475 (38%), Gaps = 24/475 (5%) Query: 43 PEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQ- 101 P P P LG++L+ K + ++YG V G PVL ++ D I+ LV++ Sbjct: 19 PGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKEC 78 Query: 102 GDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYL 161 F R + +S S W R L S + Sbjct: 79 YSVFTNRR---PFGPVGFMKS-AISIAEDEEWKRLRSLLSPTFT---------SGKLKEM 125 Query: 162 EEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVK 221 +++ L+ L+ + +VI + FG + ++ V+ Sbjct: 126 VPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVE 185 Query: 222 NTHEFVETASSGNPLDFFPILRYL-PNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSV 280 NT + + + +L P + F + FL+K+V+ + +++ Sbjct: 186 NTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQ 245 Query: 281 R---DITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKP 337 + D + S + ++V AG++T ++ +S+ + L T P Sbjct: 246 KHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHP 305 Query: 338 EIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLN 397 ++Q+K+Q+E+D V+ + P Q+ YL+ + ET R + + +D +N Sbjct: 306 DVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDVEIN 364 Query: 398 GFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRR 457 G +IPK V + + ++ DP+ W +P +F PERF + I+ FG G R Sbjct: 365 GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID---PYIYTPFGSGPRN 421 Query: 458 CIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHAR--CEHVQAR 510 CIG A + L L +LQ F ++ L G ++ + V++R Sbjct: 422 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 476 >3L4D-A nrPDB Length = 453 Score = 308 bits (790), Expect = 2e-84, Method: Composition-based stats. Identities = 79/451 (17%), Positives = 170/451 (37%), Gaps = 40/451 (8%) Query: 40 KSPPEPWGW-PLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98 K PP G P +GH++ GK+P + + ++YG + + I + V+ + + Sbjct: 3 KLPPVVHGTTPFVGHIIQFGKDPLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQHSKFF 62 Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 + + R ++Y+ + G+ + ++ P + L ++A + Sbjct: 63 TPRNEILSPR-EVYSFMVPVFGEGVAYAAPY-PRMREQLNFLAEEL---TVAKFQNF--A 115 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSD--EM 216 ++ V K KA ++ + G + + + N FG+ + D + Sbjct: 116 PSIQHEVRKFMKANWNKDE------GEINILDDCSAMIINTACQCLFGEDLRKRLDARQF 169 Query: 217 LSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTV--QEHYQD 274 L+ + A+ F P + LP P R + L + + +E + Sbjct: 170 AQLLAKMESCLIPAAV-----FLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEEA 224 Query: 275 FDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLV 334 + D+ L + G + Q ++ ++ AG T T +WSL++L+ Sbjct: 225 QKDTNTSDLLAGLLGAVYR----DGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLM 280 Query: 335 --TKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392 K+ +E+D + + + ++P+ E E+ R L + + Sbjct: 281 DPRNKRHLAKLHQEIDEFPAQLNYDNVME--EMPFAEQCARESIRRDPPL-VMLMRKVLK 337 Query: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFG 452 + + +P+ + + + D E + +P E+ PER + K + FG Sbjct: 338 PVQVGKYVVPEGDIIACSPLLSHQDEEAFPNPREWNPERNM--------KLVDGAFCGFG 389 Query: 453 MGKRRCIGEVLAKWEIFLFLAILLQQLEFSV 483 G +CIGE ++ LA +L+ +F + Sbjct: 390 AGVHKCIGEKFGLLQVKTVLATVLRDYDFEL 420 >4WMZ-A nrPDB Length = 539 Score = 301 bits (770), Expect = 5e-82, Method: Composition-based stats. Identities = 83/465 (17%), Positives = 165/465 (35%), Gaps = 36/465 (7%) Query: 42 PPEPWGW-PLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVR 100 PP + W P +G + G P+ ++YGD+ + + V Sbjct: 56 PPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNA 115 Query: 101 QGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCY 160 + D T G+ + + + R + Q ++ + S Sbjct: 116 KLADVSAEAAYAHLTTPVFGKGVIYDCPNS------RLMEQKKFVKGALTKEAFKSYVPL 169 Query: 161 LEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLV 220 + E V K + + G D G+ D + + Sbjct: 170 IAEEVYKYFRD-SKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYL 228 Query: 221 KNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSV 280 + + P++F LP ++ + ++E ++ D Sbjct: 229 YS-----DLDKGFTPINFV--FPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQD- 280 Query: 281 RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQ 340 RD+ +L K+S G + ++I NL+ + G T +W L++L +P++Q Sbjct: 281 RDLIDSLMKNS---TYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQ 337 Query: 341 RKIQKELDTVIGRERRPRLSDRPQ-LPYLEAFILETFRHSSFLPFTIPHSTTRDTTL--N 397 +++ +E V+ ++ D Q +P L I ET R L ++ +D + Sbjct: 338 QELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPL-HSLFRKVMKDMHVPNT 396 Query: 398 GFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGT-------------AINKPL 444 + IP V V+ + E + + +F R+ + AI+K + Sbjct: 397 SYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGV 456 Query: 445 SEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKV 489 S + FG G+ RCIGE A ++ + ++I ++ L++ P G V Sbjct: 457 SSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTV 501 >5JLC-A nrPDB Length = 515 Score = 298 bits (763), Expect = 3e-81, Method: Composition-based stats. Identities = 85/503 (16%), Positives = 176/503 (34%), Gaps = 47/503 (9%) Query: 1 MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGW-PLLGHVLTLGK 59 + L+Q V + + + L++ + K PP + W P +G + G Sbjct: 7 LPLAQRVSIMVALPFVYTITWQLLYSLRKD----------RPPLVFYWIPWVGSAIPYGT 56 Query: 60 NPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITD 119 P+ ++YGD+ + + V + D T Sbjct: 57 KPYEFFEDCQKKYGDIFSFMLLGRIMTVYLGPKGHEFIFNAKLADVSAEAAYSHLTTPVF 116 Query: 120 GQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQEL 179 G+ + + + R + Q ++ + + E + K + + Sbjct: 117 GKGVIYDCPN------HRLMEQKKFVKGALTKEAFVRYVPLIAEEIYKYFR-NSKNFKIN 169 Query: 180 MAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFF 239 G D G+ + D + + + + P++F Sbjct: 170 ENNSGIVDVMVSQPEMTIFTASRSLLGKEMRDKLDTDFAYLYS-----DLDKGFTPINFV 224 Query: 240 PILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASG 299 LP ++ Q ++E + D + RD+ L K+S G Sbjct: 225 --FPNLPLEHYRKRDHAQQAISGTYMSLIKERREKNDIQN-RDLIDELMKNS---TYKDG 278 Query: 300 NLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRE-RRPR 358 + ++I NL+ + G T +W L++L +P++Q ++ +E V+ + + Sbjct: 279 TKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQEQMRVLNNDTKELT 338 Query: 359 LSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTL--NGFYIPKKCCVFVNQWQVNH 416 D +P L I ET R L ++ RD + + +P+ V V+ + Sbjct: 339 YDDLQNMPLLNQMIKETLRLHHPL-HSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHL 397 Query: 417 DPELWEDPSEFRPERFLTADGT--------------AINKPLSEKMMLFGMGKRRCIGEV 462 E + P+EF R+ + AI+K +S + FG G+ RCIGE+ Sbjct: 398 QEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGEL 457 Query: 463 LAKWEIFLFLAILLQQLEFSVPP 485 A ++ + ++I ++ +++ P Sbjct: 458 FAYCQLGVLMSIFIRTMKWRYPT 480 >5VEU-A nrPDB Length = 480 Score = 298 bits (763), Expect = 3e-81, Method: Composition-based stats. Identities = 103/446 (23%), Positives = 175/446 (39%), Gaps = 25/446 (5%) Query: 43 PEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQ- 101 P P PLLG+VL+ + + ++YG + G PVL ++ D IR LV++ Sbjct: 18 PGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKEC 77 Query: 102 GDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYL 161 F R L + +S S W R L S + Sbjct: 78 YSVFTNRRSLGP---VGFMKS-AISLAEDEEWKRIRSLLSPTFT---------SGKLKEM 124 Query: 162 EEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVK 221 +++ L+ L+ + +VI FG + ++ V+ Sbjct: 125 FPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVE 184 Query: 222 NTHEFVETASSGNPLDFFPILRYLPNPALQRFKA--FNQRFLWFLQKTVQEHYQDF---D 276 +T +F++ +PL IL P + F + + FL K+V + Sbjct: 185 STKKFLKFGFL-DPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDK 243 Query: 277 KNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTK 336 + D + S + ++ AG++T ++ +S++L L T Sbjct: 244 QKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATH 303 Query: 337 PEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTL 396 P++Q+K+QKE+D V+ + P Q+ YL+ + ET R + + + +D + Sbjct: 304 PDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFP-VAIRLERTCKKDVEI 362 Query: 397 NGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKR 456 NG +IPK V + + ++HDP+ W +P EFRPERF + FG G R Sbjct: 363 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSI----DPYIYTPFGTGPR 418 Query: 457 RCIGEVLAKWEIFLFLAILLQQLEFS 482 CIG A + L L +LQ F Sbjct: 419 NCIGMRFALMNMKLALIRVLQNFSFK 444 >2WX2-A nrPDB Length = 473 Score = 297 bits (759), Expect = 1e-80, Method: Composition-based stats. Identities = 87/457 (19%), Positives = 162/457 (35%), Gaps = 41/457 (8%) Query: 41 SPPEPWGWPLLGHVLTLGKNPHLALSRMSQRY-GDVLQIRIGSTPVLVLSRLDTIRQALV 99 P P P LGH++ GKNP + R + V I IG V ++ + Sbjct: 18 PPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFS 77 Query: 100 RQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSC 159 + + R ++YT G+ + ++ P + L +IA Sbjct: 78 PRNEILSPR-EVYTIMTPVFGEGVAYAAPY-PRMREQLNFLAEEL---TIAKFQNF--VP 130 Query: 160 YLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDE--ML 217 ++ V K + G + + N FG+ + + Sbjct: 131 AIQHEVRKFMAENWKEDE------GVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFA 184 Query: 218 SLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTV--QEHYQDF 275 L+ + A+ F P L LP P R + L + + +E + Sbjct: 185 QLLSKMESSLIPAAV-----FMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEAS 239 Query: 276 DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 335 N+ D+ G L K + G + ++ ++ AG T T SWS+++L+ Sbjct: 240 KDNNTSDLLGGLLKAVYR----DGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMH 295 Query: 336 --KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRD 393 + K+ KE+D + + D ++P+ E + E+ R L + + Sbjct: 296 PKNKKWLDKLHKEIDEFPAQLNYDNVMD--EMPFAERCVRESIRRDPPL-LMVMRMVKAE 352 Query: 394 TTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGM 453 + + +PK + + +HD E + +P + PER DG + FG Sbjct: 353 VKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDG---------AFIGFGA 403 Query: 454 GKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVD 490 G +CIG+ A ++ LA ++ +F + D Sbjct: 404 GVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPD 440 >6AYB-A nrPDB Length = 466 Score = 295 bits (756), Expect = 2e-80, Method: Composition-based stats. Identities = 89/452 (19%), Positives = 165/452 (36%), Gaps = 32/452 (7%) Query: 37 KGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQ 96 KG P P P +G ++ KNP + S++YGDV I + L+ + Sbjct: 8 KGKLPPRVPNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFLNHPKILDT 67 Query: 97 ALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASS 156 ++ R D+Y G + + DS + + + + + Sbjct: 68 FFKATDNELSLR-DVYRFMRPVFGTGVVYDADSTERMMEQVKFVSS-----GLTTARFRV 121 Query: 157 SSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEM 216 E+ ++ + K L G D + + G + E Sbjct: 122 FVDIFEDEIAHKVKEL--------GPEGTVDVAELMADLIIFTASRCLLGDEVRQYLSEK 173 Query: 217 LSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAF-NQRFLWFLQKTVQEHYQDF 275 +L K H+ + S PL FF LP P + + + F L K +EH + Sbjct: 174 -NLGKLYHDIDDGIS---PLSFF--YPSLPAPKRDKARKAVGEIFQELLDKRREEHKKHP 227 Query: 276 DK---NSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332 ++ S D+ L K G + + ++ AG T + SW+LM Sbjct: 228 ERLLDESKMDVVDHLLTQKYK----DGQELTDVHRIGILIAGLFAGQHTSSITSSWTLMN 283 Query: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392 +++ ++ K++KE + ++G ++ ++ YLEA + E R L I + Sbjct: 284 VISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPL-IMIMRMARK 342 Query: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFG 452 + IPK + V+ + + +P F PER ++ + FG Sbjct: 343 PRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERLTERKE---HEKFKYGAVPFG 399 Query: 453 MGKRRCIGEVLAKWEIFLFLAILLQQLEFSVP 484 G+ +CIGE A ++ ++ILL+ + Sbjct: 400 AGRHKCIGENFALLQVKSIISILLRYFDMEYI 431 >2VE3-A nrPDB Length = 444 Score = 286 bits (731), Expect = 2e-77, Method: Composition-based stats. Identities = 100/459 (21%), Positives = 181/459 (39%), Gaps = 39/459 (8%) Query: 33 PRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLD 92 P L PP +G P LG L + R Q++G + + R+ V+ +S Sbjct: 5 PTNLNSLPIPPGDFGLPWLGETLNFLNDGDFGKKR-QQQFGPIFKTRLFGKNVIFISGAL 63 Query: 93 TIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASD 152 R ++ + F+ L T L+ +T G + +RR++ A ++ S Sbjct: 64 ANRFLFTKEQETFQATWPLSTRILLGPN---ALATQMGEIHRSRRKILYQAFLPRTLDSY 120 Query: 153 PASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPES 212 + ++ E Y Q+ +V + G Sbjct: 121 -------------LPKMDGIVQGYLEQWGKANEVIWYPQLRRMTFDVAATLFMG------ 161 Query: 213 SDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHY 272 E +S + ET G F + LPN + + L L+K ++ Sbjct: 162 --EKVSQNPQLFPWFETYIQG----LFSLPIPLPNTLFGKSQRARALLLAELEKIIKARQ 215 Query: 273 QDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMY 332 Q S D G L + + ++ + + + AG +T+T+A+S + Sbjct: 216 Q--QPPSEEDALGILLAARDDNNQ----PLSLPELKDQILLLLFAGHETLTSALSSFCLL 269 Query: 333 LVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR 392 L +I+ ++++E + + + ++PYL+ + E R + + Sbjct: 270 LGQHSDIRERVRQEQNK-LQLSQELTAETLKKMPYLDQVLQEVLRLIPPVG-GGFRELIQ 327 Query: 393 DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFG 452 D GF+ PK V Q + DP+L+ DP +F PERF T DG+A + P + FG Sbjct: 328 DCQFQGFHFPKGWLVSYQISQTHADPDLYPDPEKFDPERF-TPDGSATHNP-PFAHVPFG 385 Query: 453 MGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDL 491 G R C+G+ A+ E+ LF L+QQ ++++ PG ++L Sbjct: 386 GGLRECLGKEFARLEMKLFATRLIQQFDWTLLPGQNLEL 424 >3EL3-A nrPDB Length = 467 Score = 284 bits (726), Expect = 7e-77, Method: Composition-based stats. Identities = 107/470 (22%), Positives = 190/470 (40%), Gaps = 35/470 (7%) Query: 33 PRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLD 92 P P+ + P G PLLGH L ++P +S++ +GDV++I++G V ++ + Sbjct: 16 PGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRD-HGDVVRIKLGPKTVYAVTNPE 74 Query: 93 TIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASD 152 + AL D P L+ S G+ +T +GP+ +RR Q A D Sbjct: 75 -LTGALALNPDYHIAGP-LWESLEGLLGKEGV-ATANGPLHRRQRRTIQPAFRL-----D 126 Query: 153 PASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCF-GQHFPE 211 + +E +EA AL R Q D ++ V GQ+ E Sbjct: 127 AIPAYGPIME----EEAHALTERWQ----PGKTVDATSESFRVAVRVAARCLLRGQYMDE 178 Query: 212 SSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEH 271 ++ + + + + P+ R LP PA +RF + + + E Sbjct: 179 RAERLCVALATVFRGMYRRM---VVPLGPLYR-LPLPANRRFNDALADLHLLVDEIIAER 234 Query: 272 YQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLM 331 K D+ AL + +G+ I +++I + V I G +T+ + I W L Sbjct: 235 RASGQK--PDDLLTALLEAKDD----NGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQ 288 Query: 332 YLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTT 391 L PE +I+ E++ V G R D +L + I+E R + + + Sbjct: 289 ALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAV-WVLTRRAV 346 Query: 392 RDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLF 451 ++ L G+ IP + + + + DP+ ++D EF P+R+L + K M F Sbjct: 347 AESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPK---YAMKPF 403 Query: 452 GMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKH 501 GKR+C + + ++ L A L + F G + G+T++ Sbjct: 404 SAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAV--RVGITLRP 451 >3K9V-A nrPDB Length = 482 Score = 283 bits (723), Expect = 2e-76, Method: Composition-based stats. Identities = 106/491 (21%), Positives = 201/491 (40%), Gaps = 56/491 (11%) Query: 43 PEPWGWPLLGHVLTLG-----KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQA 97 P P WPLLG +L + K H L+ ++YG + ++++GS + L ++ +A Sbjct: 27 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSP-SLLEA 85 Query: 98 LVRQGDDFKGRPDLYTSTLITDGQSLTFSTD--SGPVWAARRRLAQNALNTFSIASDPAS 155 L R R ++ D ++ + G W R Q L Sbjct: 86 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMK--------P 137 Query: 156 SSSCYLEEHVSKEAKALISRLQELMAGPGHF-DPYNQV----VVSVANVIGAMCFGQHFP 210 L++ +++ + R+ EL G D Y+++ S+ V+ FG Sbjct: 138 VEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQK 197 Query: 211 ESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQE 270 E+ +E L+ + + T F + P +R K Q Sbjct: 198 ETEEEALTFITAIKTMMST---------FGKMMVTPVELHKRLNT----------KVWQA 238 Query: 271 HYQDFDK--NSVRDITGALFKHSKKGPRAS-------GNLIPQEKIVNLVNDIFGAGFDT 321 H +D SV+ + + P A + + ++++ V ++ A +T Sbjct: 239 HTLAWDTIFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVET 298 Query: 322 VTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSF 381 ++ W L L P+ QR++ +E+ +V+ + PR D +PYL+A + E+ R + Sbjct: 299 TANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPS 358 Query: 382 LPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAIN 441 +PFT + + T L + +PK + +N + + +ED +FRPER+L + Sbjct: 359 VPFT-TRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEK---- 413 Query: 442 KPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKH 501 K + FG+GKR CIG LA+ ++ L L ++Q+ + V++ ++ + Sbjct: 414 KINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEM--LHLGILVP 471 Query: 502 ARCEHVQARLR 512 +R + R R Sbjct: 472 SRELPIAFRPR 482 >2W0A-A nrPDB Length = 455 Score = 278 bits (711), Expect = 4e-75, Method: Composition-based stats. Identities = 89/466 (19%), Positives = 169/466 (36%), Gaps = 31/466 (6%) Query: 52 GHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDL 111 GH+ +P + R+ GDV ++ V++LS + R GDD + Sbjct: 17 GHLEEFRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHA-NEFFFRAGDDDLDQAKA 75 Query: 112 YTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKA 171 Y G+++ F R+ + NA ++ + + +E+ V + Sbjct: 76 YPFMTPIFGEAVVFDAS----PERRKEMLHNA----ALRGEQMKGHAATIEDQVRR---- 123 Query: 172 LISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETAS 231 +I+ E G D + A G+ F + D + + + E Sbjct: 124 MIADWGE----AGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKL-----YHELER 174 Query: 232 SGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF-DKNSVRDITGALFKH 290 +PL + YLP + +R + + + + S RD+ L Sbjct: 175 GTDPLAYV--DPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAV 232 Query: 291 SKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTV 350 + ++I + + AG T + SW+L+ L+ + + ELD + Sbjct: 233 KAETGTP---RFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDEL 289 Query: 351 IGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVN 410 G R Q+P LE + ET R L + + + G I + V + Sbjct: 290 YGDGRSVSFHALRQIPQLENVLKETLRLHPPL-IILMRVAKGEFEVQGHRIHEGDLVAAS 348 Query: 411 QWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFL 470 N PE + DP +F P R+ + + + FG G+ RC+G A +I Sbjct: 349 PAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWT--WIPFGAGRHRCVGAAFAIMQIKA 406 Query: 471 FLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN 516 ++LL++ EF + + + ++ A+ V+ R R ++ Sbjct: 407 IFSVLLREYEFEMAQPPESYRNDHSKMVVQLAQPAAVRYRRRTGVH 452 >2X2N-A nrPDB Length = 475 Score = 269 bits (688), Expect = 2e-72, Method: Composition-based stats. Identities = 77/457 (16%), Positives = 159/457 (34%), Gaps = 41/457 (8%) Query: 41 SPPEPWGWPLLGHVLTLGKNPHLALSRMSQRY-GDVLQIRIGSTPVLVLSRLDTIRQALV 99 P P P+LGH++ GK+P + ++ + I I V ++ + + Sbjct: 18 PPVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHSRFFL 77 Query: 100 RQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSC 159 + + R ++Y+ + G+ + ++ P + L +IA Sbjct: 78 PRNEVLSPR-EVYSFMVPVFGEGVAYAAPY-PRMREQLNFLAEEL---TIAKFQNF--VP 130 Query: 160 YLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSD--EML 217 ++ V K A + + G + + N FG+ + D Sbjct: 131 AIQHEVRKFMAANWDKDE------GEINLLEDCSTMIINTACQCLFGEDLRKRLDARRFA 184 Query: 218 SLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF-- 275 L+ + A+ F PIL LP P R L + + Sbjct: 185 QLLAKMESSLIPAAV-----FLPILLKLPLPQSARCHEARTELQKILSEIIIARKAAAVN 239 Query: 276 DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 335 +S D+ L + G + ++ ++ AG T + +WS+++L+ Sbjct: 240 KDSSTSDLLSGLLSAVYR----DGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMH 295 Query: 336 KPEIQ--RKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRD 393 ++ ++KE++ + + D ++P+ E E+ R L + D Sbjct: 296 PANVKHLEALRKEIEEFPAQLNYNNVMD--EMPFAERCARESIRRDPPL-LMLMRKVMAD 352 Query: 394 TTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGM 453 + + +PK + + +HD E + +P + PER +G + FG Sbjct: 353 VKVGSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPERDEKVEG---------AFIGFGA 403 Query: 454 GKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVD 490 G +CIG+ ++ LA + +F + D Sbjct: 404 GVHKCIGQKFGLLQVKTILATAFRSYDFQLLRDEVPD 440 >3MDV-A nrPDB Length = 456 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 90/449 (20%), Positives = 181/449 (40%), Gaps = 37/449 (8%) Query: 65 LSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSL- 123 +++YG V+++ + ++++ +++++ L+ + +Y + G+ L Sbjct: 16 FLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLM--STKYNKDSKMYRALQTVFGERLF 73 Query: 124 ---TFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM 180 S + W +RR+ A + S+ S L E +++A+ L+ L+ Sbjct: 74 GQGLVSECNYERWHKQRRVIDLAFSRSSLVS---------LMETFNEKAEQLVEILEAKA 124 Query: 181 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP 240 G + + + +++ FG + +L K + V+ G Sbjct: 125 DGQTPVSMQDMLTYTAMDILAKAAFGME----TSMLLGAQKPLSQAVKLMLEGITASRNT 180 Query: 241 ILRYLPNP--ALQRFKAFNQRFLWFLQKTVQEHYQDFDKNS--VRDITGALFKHSKKGPR 296 + ++LP L+ + + + VQ + + DI + K + Sbjct: 181 LAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQ- 239 Query: 297 ASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERR 356 E +++ F AG +T +++++M L +PEI ++Q E+D VIG +R Sbjct: 240 ------DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY 293 Query: 357 PRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNH 416 D +L YL + E+ R + +T ++G +P + + + + Sbjct: 294 LDFEDLGRLQYLSQVLKESLRLYPPA-WGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGR 352 Query: 417 DPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILL 476 +EDP F P+RF G KP F +G R CIG+ A+ E+ + +A LL Sbjct: 353 MDTYFEDPLTFNPDRF----GPGAPKPR-FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLL 407 Query: 477 QQLEFSVPPGVKVDLTPIYGLT-MKHARC 504 Q+LEF + PG + L L + C Sbjct: 408 QRLEFRLVPGQRFGLQEQATLKPLDPVLC 436 >6C94-A nrPDB Length = 497 Score = 226 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 88/455 (19%), Positives = 165/455 (36%), Gaps = 33/455 (7%) Query: 43 PEPWGWPLLGHVLTLGKNPHL-ALSRMSQRYGDVLQIRIGST-PVLVLSRLDTIRQALVR 100 P P L GH L + K L + +Q++ + +G L + D + A+ Sbjct: 25 PGPPTHWLFGHALEIQKTGSLDKVVTWTQQFPYAHPLWVGQFIGFLNIYEPDYAK-AVYS 83 Query: 101 QGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCY 160 +GD PD+Y L G+ L GP W R+L + D Sbjct: 84 RGD--PKAPDVYDFFLQWIGKGLLV--LDGPKWFQHRKLLTPGFHY-----DVLKPYVAI 134 Query: 161 LEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQH---FPESSDEML 217 + + ++ + ++ FD ++ V + + FG+ Sbjct: 135 FADS----TRIMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSYY 190 Query: 218 SLVKNTHEFVE-TASSGNPL-DFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF 275 V ++ S DF L P +RF + + +++ Sbjct: 191 VAVSELTLLMQQRIDSFQYHNDFIYWL----TPHGRRFLRACRAAHDHTDRVIRQRKAAL 246 Query: 276 DKNSVRDITG-----ALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSL 330 R+ SG + + V+ G DT T+ ISW L Sbjct: 247 QDEKEREKIQNRRHLDFLDILLDVRGESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFL 306 Query: 331 MYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHST 390 + PE Q++ ++E+ ++G + + D ++ YL + E FR +P + Sbjct: 307 YCMALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLS 366 Query: 391 TRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMML 450 + ++G +P + ++ + ++ + ++W DP F P RF + + + + Sbjct: 367 KPVSFVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRH---PYAFIP 423 Query: 451 FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPP 485 F G R CIG+ A E+ + A+ L + EFSV P Sbjct: 424 FSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSVDP 458 >4KPA-A nrPDB Length = 494 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 93/469 (19%), Positives = 166/469 (35%), Gaps = 41/469 (8%) Query: 43 PEPWGWPLLGHVLTLGKN-PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQ 101 P+P + L ++ L + P AL +++ G++ + LS I++A + Sbjct: 30 PQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEA-CDE 88 Query: 102 GDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYL 161 K G L S W + + + + Sbjct: 89 SRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFS-----QQAMKGYHAMM 143 Query: 162 EEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFP--ESSDE---M 216 + A L+ + + L A H + + + IG F F + Sbjct: 144 VDI----AVQLVQKWERLNADE-HIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFI 198 Query: 217 LSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFD 276 S+V+ E + NP D P + ++F+ + + K + + + Sbjct: 199 TSMVRALDEAMNKLQRANPDD--PAY----DENKRQFQEDIKVMNDLVDKIIADRKASGE 252 Query: 277 KNSVRDITGALFKHSKKGPR-ASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 335 ++ L H G +G + E I + AG +T + +S++L +LV Sbjct: 253 QS------DDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVK 306 Query: 336 KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTT 395 P + +K +E V+ + P QL Y+ + E R P DT Sbjct: 307 NPHVLQKAAEEAARVL-VDPVPSYKQVKQLKYVGMVLNEALRLWPTAP-AFSLYAKEDTV 364 Query: 396 LNG-FYIPKKCCVFVNQWQVNHDPELW-EDPSEFRPERFLTADGTAINKPLSEKMMLFGM 453 L G + + K + V Q++ D +W +D EFRPERF FG Sbjct: 365 LGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIP-----QHAFKPFGN 419 Query: 454 GKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHA 502 G+R CIG+ A E L L ++L+ +F ++D+ LT+K Sbjct: 420 GQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKET--LTLKPE 466 >3MZS-A nrPDB Length = 486 Score = 209 bits (531), Expect = 3e-54, Method: Composition-based stats. Identities = 89/479 (18%), Positives = 172/479 (35%), Gaps = 32/479 (6%) Query: 36 PKGLKSPPEPWGWPLLGHVLTLGKNPHLALS--RMSQRYGDVLQIRIGSTPVLVLSRLDT 93 P P GW L H + + Q+YG + + ++G+ + + + Sbjct: 9 PYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPED 68 Query: 94 IRQALVRQGDDFKGRPDLYTSTLITD--GQSLTFSTDSGPVWAARRRLAQNALNTFSIAS 151 + +G + R D+ + + W R + LNT +A Sbjct: 69 VAHLFKFEGS-YPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVV----LNTEVMAP 123 Query: 152 DPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV----VSVANVIGAMCFGQ 207 + + L L R+++ +G D + S+ NV+ G Sbjct: 124 EAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGM 183 Query: 208 HFPESSDEMLSLVKNTHEFVETASSGNPLDFFP--ILRYLPNPALQRFKAFNQRFLWFLQ 265 + E + ++ T+ PL P + R + A + Sbjct: 184 LEETVNPEAQKFIDAVYKMFHTS---VPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAE 240 Query: 266 KTVQEHYQDFDKNSV-RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTT 324 K + YQD + + R+ G L+ K + E + + ++ G +T + Sbjct: 241 KYTEIFYQDLRRKTEFRNYPGILYCLLK------SEKMLLEDVKANITEMLAGGVNTTSM 294 Query: 325 AISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPF 384 + W L + +Q +++E+ + +P L+A I ET R + Sbjct: 295 TLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHP-ISV 353 Query: 385 TIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPL 444 T+ D L + IP K V V + + DP + P +F P R+L+ D I+ Sbjct: 354 TLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHF-- 411 Query: 445 SEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHAR 503 + + FG G R+C+G +A+ E+ LFL +L+ + + D+ I+ L + + Sbjct: 412 --RNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEM--QHIGDVDTIFNLILTPDK 466 >3N9Z-A nrPDB Length = 487 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 89/490 (18%), Positives = 169/490 (34%), Gaps = 45/490 (9%) Query: 32 RPRVPKGLKSPPEPWGWPLLGHVLTLG--KNPHLALSRMSQRYGDVLQIRIGSTPVLVLS 89 R P P GW L H HL + Q+YG + + ++G+ + + Sbjct: 3 RSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVI 62 Query: 90 RLDTIRQALVRQGDDFKGRPDLYTSTLITD--GQSLTFSTDSGPVWAARRRLAQNALNTF 147 + + +G + R + + + W R ALN Sbjct: 63 DPEDVALLFKSEGPN-PERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDR----VALNQE 117 Query: 148 SIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207 +A + + L+ L R+++ +G D + + I + FG+ Sbjct: 118 VMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGE 177 Query: 208 HF----PESSDEMLSLVKNTHEFVETA--SSGNPLDFFPILRYLPNPAL--------QRF 253 + E + ++ T+ P D F + R + Sbjct: 178 RQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKA 237 Query: 254 KAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVND 313 + Q F W L++ H+ R I L + + E I V + Sbjct: 238 DIYTQNFYWELRQKGSVHH------DYRGILYRLL---------GDSKMSFEDIKANVTE 282 Query: 314 IFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFIL 373 + G DT + + W L + ++Q ++ E+ + + + +P L+A I Sbjct: 283 MLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIK 342 Query: 374 ETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL 433 ET R + T+ D L + IP K V V + + +P + DP F P R+L Sbjct: 343 ETLRLHP-ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWL 401 Query: 434 TADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTP 493 + D + + FG G R+C+G +A+ E+ +FL +L+ + D+ Sbjct: 402 SKDKNI----TYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEI--QHLSDVGT 455 Query: 494 IYGLTMKHAR 503 + L + + Sbjct: 456 TFNLILMPEK 465 >3S79-A nrPDB Length = 503 Score = 201 bits (511), Expect = 6e-52, Method: Composition-based stats. Identities = 76/474 (16%), Positives = 173/474 (36%), Gaps = 43/474 (9%) Query: 37 KGLKSPPEPWGWPLLGHVLTLGKNPHLALSR----MSQRYGDVLQIRIGSTPVLVLSRLD 92 +G S P P +G +++ G+ + + ++ YG+ +++ I L++S+ Sbjct: 42 EGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSS 101 Query: 93 TIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASD 152 ++ + + I + ++ +W R AL+ + Sbjct: 102 SMFHIM-KHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVR- 159 Query: 153 PASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPES 212 + ++ K + RL+E+ G+ D + + + + ES Sbjct: 160 --------MVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDES 211 Query: 213 SDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHY 272 ++ + + + L ++++ + ++ + E Sbjct: 212 -AIVVKIQGYFDAWQALLIKPDIFFKISWL-------YKKYEKSVKDLKDAIEVLIAEKR 263 Query: 273 QDFDKNSV----RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISW 328 + D L K+G + +E + + ++ A DT++ ++ + Sbjct: 264 RRISTEEKLEECMDFATELILAEKRGD------LTRENVNQCILEMLIAAPDTMSVSLFF 317 Query: 329 SLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPH 388 L + P ++ I KE+ TVIG ER ++ D +L +E FI E+ R+ + + Sbjct: 318 MLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDL-VMR 375 Query: 389 STTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKM 448 D ++G+ + K + +N +++ E + P+EF E F Sbjct: 376 KALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAK-------NVPYRYF 427 Query: 449 MLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVD-LTPIYGLTMKH 501 FG G R C G+ +A + L LL++ G V+ + I+ L++ Sbjct: 428 QPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHP 481 >5VWS-A nrPDB Length = 393 Score = 188 bits (477), Expect = 5e-48, Method: Composition-based stats. Identities = 83/434 (19%), Positives = 143/434 (32%), Gaps = 76/434 (17%) Query: 74 DVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVW 133 V + + G + + R D +RQ L R L + +T P Sbjct: 32 PVWRDQFG---IYHVFRYDDVRQILGDYQTFSSDRTRLMPTAQGFGKGGITMIDP--PEH 86 Query: 134 AARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV 193 +RRL +A SI++ +E + + A L+ L FD Sbjct: 87 RHQRRLITHAFTPQSISA---------MEPRIRQIADHLLDELP-----GPEFDLVEHFA 132 Query: 194 VSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRF 253 + ++ A G + + + S ++ +P L R Sbjct: 133 YPLPVIVIAELLGVPPGDR--------HLFRTWSDRLMSLQVENYA-------DPELART 177 Query: 254 KAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVND 313 A + ++EH + + D+ L + +G R + E++VN + Sbjct: 178 VAAAM---TEMNDYLREHCRSRRTHPRDDLLTRLVQAEVEGKR-----LDLEEVVNTASL 229 Query: 314 IFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFIL 373 + AG T T I +++ L PE ++ ++ + + A + Sbjct: 230 LLLAGHLTTTVLIGNTMLCLWDHPEAEKAVRADP------------------SLIPAALE 271 Query: 374 ETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL 433 E+ R S TTRD T+ G IP V NHD + DP F R Sbjct: 272 ESLRLRSPF-LQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFDLHR-- 328 Query: 434 TADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVP---PGVKVD 490 + + FG G C+G L + E + L LL + P G+ Sbjct: 329 ----------QTTGHIAFGHGVHFCLGAQLGRLEGRIALERLLGRFTEIHPWPREGISFY 378 Query: 491 LTPIYGLTMKHARC 504 + I+G + RC Sbjct: 379 QSAIFGASRMPVRC 392 >2VZM-A nrPDB Length = 436 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 51/292 (17%), Positives = 101/292 (34%), Gaps = 51/292 (17%) Query: 214 DEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFL------------ 261 D ML+ + +E+ + P+ L +P P F+ + F+ Sbjct: 152 DAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAM 211 Query: 262 WFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDT 321 + + D+ AL + S + G+ + E+++ + + + AG +T Sbjct: 212 AEMSGYLSRLIDSKRGQDGEDLLSALVRTSDE----DGSRLTSEELLGMAHILLVAGHET 267 Query: 322 VTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSF 381 I+ + L++ P+ ++ + + L+ + E R+ Sbjct: 268 TVNLIANGMYALLSHPDQLAALRAD------------------MTLLDGAVEEMLRYEGP 309 Query: 382 LPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAIN 441 + L+G IP V V + PE + DP F R Sbjct: 310 VESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTA------- 362 Query: 442 KPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTP 493 + FG G CIG LA+ E + + LL++ P + +D++P Sbjct: 363 -----GHLAFGHGIHFCIGAPLARLEARIAVRALLERC-----PDLALDVSP 404 >4ZGX-A nrPDB Length = 489 Score = 179 bits (453), Expect = 4e-45, Method: Composition-based stats. Identities = 73/410 (17%), Positives = 145/410 (35%), Gaps = 23/410 (5%) Query: 59 KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLIT 118 ++ HL + + Q G + + +G ++ + + + + L + R L Sbjct: 39 EHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDV-EKLQQVDSLHPCRMILEPWVAYR 97 Query: 119 DGQS--LTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRL 176 + +GP W R + LN ++ ++ ++AL ++ Sbjct: 98 QHRGHKCGVFLLNGPEW----RFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKV 153 Query: 177 QELMAGPGHFDPYNQVVVSVANVIGAMCFGQHF-PESSDEMLSLVKNTHEFVETASSGNP 235 + G D + FG+ + + H S Sbjct: 154 LQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQ 213 Query: 236 LDFFP--ILRYL-PNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSK 292 L F P + R++ P + F+A++ F + +Q+ YQ+ N + TG + + Sbjct: 214 LMFMPRSLSRWISPKVWKEHFEAWDCIFQ-YGDNCIQKIYQELAFNRPQHYTGIVAELLL 272 Query: 293 KGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG 352 K + E I ++ DT + +L L P++Q+ +++E Sbjct: 273 KAE------LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAA 326 Query: 353 RERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQW 412 +LP L A + ET R F + + D L ++IP V V + Sbjct: 327 SISEHPQKATTELPLLRAALKETLRLYPVGLF-LERVVSSDLVLQNYHIPAGTLVQVFLY 385 Query: 413 QVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEV 462 + + L+ P + P+R+L G+ N + FG G R+C+G Sbjct: 386 SLGRNAALFPRPERYNPQRWLDIRGSGRNF----HHVPFGFGMRQCLGRR 431 >3EJB-B nrPDB Length = 404 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 75/448 (16%), Positives = 144/448 (32%), Gaps = 78/448 (17%) Query: 56 TLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYT-- 113 KNP+ + + + + P ++ + A + + FK R L Sbjct: 10 EFLKNPYSFYDTLRAVH-PIYKGSFLKYPGWYVTGYE--ETAAILKDARFKVRTPLPESS 66 Query: 114 --STLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKA 171 ++ Q+ + P R LA A + + + ++ + Sbjct: 67 TKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTPRT---------TESYQPYIIETVHH 117 Query: 172 LISRLQELMAGPGHFDPYNQV-VVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETA 230 L+ ++Q D + +AN+IG PE E L A Sbjct: 118 LLDQVQGKKKMEVISDFAFPLASFVIANIIG-------VPEEDREQLKEWA--------A 162 Query: 231 SSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKH 290 S +DF ++ +E Q ++ +D+ L K Sbjct: 163 SLIQTIDF---------TRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKG 213 Query: 291 SKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTV 350 +K + + +E+ + + AG +T IS S++ L+ PE K+++ D Sbjct: 214 REK------DKLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPD-- 265 Query: 351 IGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVN 410 + + E R+ S T + D + G I + V++ Sbjct: 266 ----------------LIGTAVEECLRYESPTQMT-ARVASEDIDICGVTIRQGEQVYLL 308 Query: 411 QWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFL 470 N DP ++ +P F R + FG G C+G LA+ E + Sbjct: 309 LGAANRDPSIFTNPDVFDITR------------SPNPHLSFGHGHHVCLGSSLARLEAQI 356 Query: 471 FLAILLQQLEFSVPPGVKVDLTPIYGLT 498 + LLQ++ + P++G Sbjct: 357 AINTLLQRMPSLNLADFEWRYRPLFGFR 384 >3NC3-A nrPDB Length = 441 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 82/425 (19%), Positives = 150/425 (35%), Gaps = 63/425 (14%) Query: 56 TLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTST 115 NP+ S++ + V S +SR +R L + D F + + + Sbjct: 50 QFQNNPYAYFSQLREE-DPVH--YEESIDSYFISRYHDVRYIL-QHPDIFTTKSLVERAE 105 Query: 116 LITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISR 175 + + + G +A+RR+ + ++ +L + + A+ L++ Sbjct: 106 PV--MRGPVLAQMHGKEHSAKRRIVVRSFIGDALD---------HLSPLIKQNAENLLAP 154 Query: 176 LQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNP 235 E G +V + +ML L K HE + SG Sbjct: 155 YLER--GKSDLVNDFGKTFAVCVTM--------------DMLGLDKRDHEKISEWHSG-V 197 Query: 236 LDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGP 295 DF + P A +++ +L ++E N D+ L Sbjct: 198 ADFITSISQSP-EARAHSLWCSEQLSQYLMPVIKERR----VNPGSDLISILCTSEY--- 249 Query: 296 RASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRER 355 G + + I+ L+ ++ A + ++ + +L+ PE + Sbjct: 250 --EGMALSDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDV------------ 295 Query: 356 RPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVN 415 L+DR +P I ET R+ + IP ++DT + G I K VF N Sbjct: 296 ---LADRSLVP---RAIAETLRYKPPVQL-IPRQLSQDTVVGGMEIKKDTIVFCMIGAAN 348 Query: 416 HDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAIL 475 DPE +E P F R +A + + + + FG G C+G AK EI + I+ Sbjct: 349 RDPEAFEQPDVFNIHREDLGIKSAFS--GAARHLAFGSGIHNCVGTAFAKNEIEIVANIV 406 Query: 476 LQQLE 480 L ++ Sbjct: 407 LDKMR 411 >4Z5Q-A nrPDB Length = 423 Score = 172 bits (435), Expect = 4e-43, Method: Composition-based stats. Identities = 84/487 (17%), Positives = 160/487 (32%), Gaps = 118/487 (24%) Query: 43 PEPWGWPLLGH-VLTLGKNPHLALSRMSQRYGDVLQIRI-GSTPVLVLSRLDTIRQALVR 100 P P +P G L L ++ GD +++++ P +++R D R L Sbjct: 33 PAPVAYPFTGSEGLELSQSYAKLFED-----GDPIRVQLPFGEPAWLVTRYDDARFVLTD 87 Query: 101 Q--GDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 + + D T +S+ T P R L A I S A Sbjct: 88 RRFSRHLATQRDEPRMTPRAVPESIL--TMDPPDHTRLRTLVSKAFTPRRIESKRA---- 141 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218 + + A L++ ++ A Sbjct: 142 -----WIGELAAGLVADMKAGGA------------------------------------- 159 Query: 219 LVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF--------------L 264 E V + + P+ L +P R + + L L Sbjct: 160 ----PAELVGSYALAIPVTVICELLGVPEDDRTRLRGWCDAALSTGELTDEECVQSFMDL 215 Query: 265 QKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTT 324 QK ++ ++ D+T AL + R + + + + +++ L I GF+T + Sbjct: 216 QKYFEDLVKERRAEPRDDLTSALIEA-----RDAHDRLAEPELIGLCISILIGGFETTAS 270 Query: 325 AISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPF 384 IS + L + E+ ++ + + + A + E R F Sbjct: 271 EISSFVHVLQQRRELWTRLCADPEAI------------------PAAVEELLRFVPFAAN 312 Query: 385 TI-PHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKP 443 I P D T+ G + + V V+ VN D ++++ E +R Sbjct: 313 GISPRYALEDMTVGGVLVREGEPVIVDTSAVNRDGLVFDNADEVVIDR------------ 360 Query: 444 LSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKV--DLTPIYGLTMKH 501 + M+FG G C+G LA+ E+ L L++ + PG+++ D+ + ++ Sbjct: 361 ADNRHMVFGHGAHHCLGAHLARVELQEALKALVEGM-----PGLRLSGDVEWKADMIIRA 415 Query: 502 ARCEHVQ 508 R HV+ Sbjct: 416 PRVMHVE 422 >3SN5-A nrPDB Length = 491 Score = 171 bits (433), Expect = 7e-43, Method: Composition-based stats. Identities = 85/486 (17%), Positives = 157/486 (32%), Gaps = 51/486 (10%) Query: 42 PPEPWGW-PLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVR 100 PP G P LG L G NP L +++G V ++ V ++ + + L Sbjct: 15 PPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLC- 73 Query: 101 QGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCY 160 G F + + + G G L ++ S + Sbjct: 74 HGKYFDWKKFHFALSAKAFGHRSI-DPMDGNTTENINDTFIKTLQGHALNS-----LTES 127 Query: 161 LEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLV 220 + E++ + + +S + A Y+ + FG+ + ++ Sbjct: 128 MMENLQRIMRPPVSSNSKTAAWVTE-GMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHIL 186 Query: 221 KNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSV 280 N F + F ++ LP + ++ L+ H + S+ Sbjct: 187 NNLDNFKQFDKV-----FPALVAGLPIHMFRTAHNAREKLAESLR-----HENLQKRESI 236 Query: 281 RDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQ 340 ++ + + + + A A WSL ++ PE Sbjct: 237 SELISLRM-----FLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAM 291 Query: 341 RKIQKELDTVI-GRERRPRLSDRP---------QLPYLEAFILETFRHSSFLPFTIPHST 390 + +E+ + ++ L P LP L++ I E+ R SS + Sbjct: 292 KAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS--LNIRTA 349 Query: 391 TRDTTL----NGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK---- 442 D TL + I K + + ++ DPE++ DP F+ +R+L +G Sbjct: 350 KEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCN 409 Query: 443 --PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV----KVDLTPIYG 496 L M FG G C G + A EI FL ++L E + G +D G Sbjct: 410 GLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLD-QSRAG 468 Query: 497 LTMKHA 502 L + Sbjct: 469 LGILPP 474 >6M7X-A nrPDB Length = 484 Score = 171 bits (432), Expect = 9e-43, Method: Composition-based stats. Identities = 70/410 (17%), Positives = 143/410 (34%), Gaps = 23/410 (5%) Query: 59 KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLIT 118 ++ HL + + Q G + + +G ++ + + + + L + R L Sbjct: 39 EDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYR 97 Query: 119 DGQS--LTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRL 176 + +GP W R + LN ++ + ++ ++AL ++ Sbjct: 98 QHRGHKCGVFLLNGPEW----RFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKV 153 Query: 177 QELMAGPGHFDPYNQVVVSVANVIGAMCFGQHF-PESSDEMLSLVKNTHEFVETASSGNP 235 + G D + FG+ + + H S Sbjct: 154 LQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQ 213 Query: 236 LDFFP--ILRYL-PNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSK 292 L F P + R+ P + F+A++ F + +Q+ YQ+ + + T + + Sbjct: 214 LMFMPRSLSRWTSPKVWKEHFEAWDCIFQ-YGDNCIQKIYQELAFSRPQQYTSIVAELLL 272 Query: 293 KGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG 352 + + I ++ DT + +L L P +Q+ +++E Sbjct: 273 NAE------LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAA 326 Query: 353 RERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQW 412 +LP L A + ET R F + + D L ++IP V V + Sbjct: 327 SISEHPQKATTELPLLRAALKETLRLYPVGLF-LERVASSDLVLQNYHIPAGTLVRVFLY 385 Query: 413 QVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEV 462 + +P L+ P + P+R+L G+ N + FG G R+C+G Sbjct: 386 SLGRNPALFPRPERYNPQRWLDIRGSGRNF----YHVPFGFGMRQCLGRR 431 >2Y5N-A nrPDB Length = 417 Score = 170 bits (430), Expect = 2e-42, Method: Composition-based stats. Identities = 60/298 (20%), Positives = 114/298 (38%), Gaps = 60/298 (20%) Query: 225 EFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQD---------- 274 + V + P+ L +P+ RF ++ FL + T +E + Sbjct: 153 DLVAMFARQLPVRVICELLGVPSADHDRFTRWSGAFLSTAEVTAEEMQEAAEQAYAYMGD 212 Query: 275 ----FDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSL 330 K D+ AL + R + + ++++++L + AG+++ TT I+ + Sbjct: 213 LIDRRRKEPTDDLVSALVQA-----RDQQDSLSEQELLDLAIGLLVAGYESTTTQIADFV 267 Query: 331 MYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSF-LPFTIPHS 389 L+T+PE++R++ DRP+L + + + E R + P Sbjct: 268 YLLMTRPELRRQL----------------LDRPEL--IPSAVEELTRWVPLGVGTAFPRY 309 Query: 390 TTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMM 449 D TL G I V + N D + D +R + + Sbjct: 310 AVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDR------------TPNQHL 357 Query: 450 LFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVD-----LTPIYGLTMKHA 502 FG G C+G LA+ E+ + L +LLQ+L PG+++ L G+ ++ Sbjct: 358 GFGHGVHHCLGAPLARVELQVALEVLLQRL-----PGIRLGIPETQLRWSEGMLLRGP 410 >5L94-A nrPDB Length = 410 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 72/417 (17%), Positives = 136/417 (32%), Gaps = 77/417 (18%) Query: 88 LSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTF 147 + D +++ L ++ R G SL P A R L A Sbjct: 49 VFHYDGVKEVLEQKNIFSSDRRPPQNQRQTALGTSLINIDP--PKHAEMRALVNKAFTPK 106 Query: 148 SIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207 ++ + + ++ E + L++ D + + ++ A G Sbjct: 107 AMKAWEPKIA------RITNELLQEVEHLED-------IDIVEHLSYPLPVMVIADILGV 153 Query: 208 HFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKT 267 + + ++ + +G + L L Q N + + Sbjct: 154 PIEDQ--------RQFKDWSDIIVAGPSNNERETLEKL----QQEKMKANDELETYFYRI 201 Query: 268 VQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAIS 327 ++E DI L + ++G + + E+IV + AG +T T IS Sbjct: 202 IEEKRTR----PGDDIISVLLQAKEEGKQ-----LTDEEIVGFSILLLIAGNETTTNLIS 252 Query: 328 WSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIP 387 ++ L+ ++++E + L + I E R+ S + + Sbjct: 253 NTIYCLMEDKASFERLKREKE------------------LLPSGIEEVLRYRSPVQ-ALH 293 Query: 388 HSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEK 447 D TL G + V + D E +EDP F+ +R Sbjct: 294 RIVKEDVTLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDR------------KPNV 341 Query: 448 MMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL-------EFSVPPGVKVDLTPIYGL 497 M FG G C+G LA+ E + LA L+ + F + P ++ T +YGL Sbjct: 342 HMAFGRGIHFCLGAPLARIEAKIMLAELIDRYPQMDWSPSFELKP---IESTFVYGL 395 >2ZBZ-A nrPDB Length = 412 Score = 169 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 69/447 (15%), Positives = 134/447 (29%), Gaps = 84/447 (18%) Query: 60 NPHLALSRMSQRYGDVLQIRIG-STPVLVLSRLDTIRQALVR----QGDDFKGRPDLYTS 114 +++ G + ++ + V+++ + R+ L P + Sbjct: 25 QLPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPA 84 Query: 115 TLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALIS 174 F P RRR+ + I + V + + Sbjct: 85 FEAVRESPQAFIGLDPPEHGTRRRMTISEFTVKRI---------KGMRPEVEEVVHGFLD 135 Query: 175 RLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGN 234 + L AGP + + VI + L + HEF + AS Sbjct: 136 EM--LAAGPTADLVSQFALPVPSMVICRL-------------LGVPYADHEFFQDASKRL 180 Query: 235 PLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKG 294 Q +L + F + GAL Sbjct: 181 VQS----------TDAQSALTARNDLAGYLDGLI----TQFQTEPGAGLVGALVADQLAN 226 Query: 295 PRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRE 354 I +E++++ + AG +T + S S++ L+ PE ++ + V G Sbjct: 227 GE-----IDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSLVPG-- 279 Query: 355 RRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQV 414 + E R+ + T D + G I V V Sbjct: 280 ----------------AVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIA 323 Query: 415 NHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAI 474 N D ++EDP R + + FG G +C+G+ LA+ E+ + L Sbjct: 324 NRDGTVYEDPDALDIHR------------SARHHLAFGFGVHQCLGQNLARLELEVILNA 371 Query: 475 LLQQLEFSVPPGVKVDLTPIYGLTMKH 501 L+ ++ P +++ + P+ L ++ Sbjct: 372 LMDRV-----PTLRLAV-PVEQLVLRP 392 >4GGV-A nrPDB Length = 418 Score = 167 bits (423), Expect = 9e-42, Method: Composition-based stats. Identities = 65/412 (15%), Positives = 112/412 (27%), Gaps = 62/412 (15%) Query: 88 LSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTF 147 + L L ++ S P R+L A Sbjct: 58 VYGYPEAMDILNDHDTFTSDLAHLLPVSVDAPLLEGDMSQMDPPRHRKYRQLVSRAFTP- 116 Query: 148 SIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207 +E V+ + L+ + D + V V Sbjct: 117 --------RLVADMETRVADITRELLDAVDGKPEIEIAADLAYPLPVIVI---------- 158 Query: 208 HFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKT 267 E+L + + + + F + ++ L L Sbjct: 159 ------AELLGVPAGDRDLFKKWADDIIEGFSGFSFLDTSGQGEQDVRDATERLRPLLDY 212 Query: 268 VQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAIS 327 + H + + D+ L + G + +IVN+ N + G T T + Sbjct: 213 MAGHVTERRRTPREDLLTHLVQA-----EVDGERLTDNEIVNVANILLVTGHITTTMTLG 267 Query: 328 WSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIP 387 +++ L PE+ K++ + V G I E R S + Sbjct: 268 NTVLCLDADPEVAAKVRADRSLVPG------------------AIEEALRVLSPSA-ALA 308 Query: 388 HSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEK 447 T+R+ + G IPK V + N DP + DP + P R Sbjct: 309 RGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDPTRD------------PNP 356 Query: 448 MMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE-FSVPPGVKVDLTPIYGLT 498 FG G C+G LA+ E + L L + P P + Sbjct: 357 HFGFGRGIHFCLGAPLARLEGRVALNALFDRFPVLRTDPAKPPTFFPTPDMI 408 >5CJE-A nrPDB Length = 393 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 51/301 (16%), Positives = 95/301 (31%), Gaps = 50/301 (16%) Query: 219 LVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRF------------LWFLQK 266 L + + V++ + P+ L +P+ F+A + L Sbjct: 126 LPRGRADLVDSFAYPLPITVICELLGVPDIDRVTFRALSNEIVAPTGGDAELAAYERLAA 185 Query: 267 TVQEHYQDFDKN-SVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTA 325 + E D D+ G L + + + + E++ + + AG +T Sbjct: 186 YLDELIDDKRSTAPADDLLGDLIRTRAE----DDDRLSGEELRAMAFILLVAGHETTVNL 241 Query: 326 ISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFT 385 I+ + L+T P+ ++ + + L+ + E R + Sbjct: 242 ITNGVHTLLTHPDQLAALRAD------------------MTLLDGAVEEVLRFEGPVETA 283 Query: 386 IPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLS 445 + G I + V + DP DP F R Sbjct: 284 TYRYAAESMEIGGTAIAEGDPVMIGLDAAGRDPARHPDPHVFDIHR------------AP 331 Query: 446 EKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQ---LEFSVPPGVKVDLTPIYGLTMKHA 502 + + FG G C+G LA+ E + L LL++ L PPG + I G+ Sbjct: 332 QGHLAFGHGIHYCLGAPLARLEARVALRSLLERCPDLALDGPPGARPPGMLIRGVRRLPV 391 Query: 503 R 503 R Sbjct: 392 R 392 >5OFQ-A nrPDB Length = 409 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 53/302 (17%), Positives = 99/302 (32%), Gaps = 61/302 (20%) Query: 221 KNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLW------------------ 262 K + VE + P+ L +P FK ++ + Sbjct: 128 KEKFDIVEDFAGPLPIIVIAELLGVPIQDRALFKKYSDDLVSGAENNSDEAFAKMMQKRN 187 Query: 263 ----FLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAG 318 FLQ +E + +N D+ L + G + +E+++ + AG Sbjct: 188 EGVIFLQGYFKEIIAERQQNKQEDLISLLLEA-----EIDGEHLTEEEVLGFCILLLVAG 242 Query: 319 FDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRH 378 +T T I+ + Y+ ++Q ++++++ V + ET R+ Sbjct: 243 NETTTNLITNGVRYMTEDVDVQNEVRRDISLV------------------PNLVEETLRY 284 Query: 379 SSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGT 438 + I D L I + V N D +E P F R Sbjct: 285 YPPIQ-AIGRIAAEDVELGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHR------- 336 Query: 439 AINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV---KVDLTPIY 495 + + FG G C+G LA+ E + LL++ FS +D ++ Sbjct: 337 -----KTNPHVSFGFGIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPIDSPFVF 391 Query: 496 GL 497 G+ Sbjct: 392 GV 393 >3ABA-A nrPDB Length = 403 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 62/353 (17%), Positives = 110/353 (31%), Gaps = 69/353 (19%) Query: 149 IASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQH 208 +A + L ++ + L + A G D +V +++ + FG Sbjct: 102 LAKEFTVRRMQALRPNIQRIVD---EHLDAIEARGGPVDLVKTFANAVPSMVISDLFGVP 158 Query: 209 FPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTV 268 E + ++ E + +A R L + V Sbjct: 159 V-----ERRAEFQDIAEAMMRVDQ----------------DAAATEAAGMRLGGLLYQLV 197 Query: 269 QEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISW 328 QE N D+ AL ++ ++N + A DT I Sbjct: 198 QERRA----NPGDDLISALIT-----TEDPDGVVDDMFLMNAAGTLLIAAHDTTACMIGL 248 Query: 329 SLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPH 388 L+ P+ ++++ V + E R+ + F Sbjct: 249 GTALLLDSPDQLALLREDPSLV------------------GNAVEELLRYLTIGQFGGER 290 Query: 389 STTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKM 448 TRD L G I K V + + DP E+P F R Sbjct: 291 VATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITR------------RPAPH 338 Query: 449 MLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKH 501 + FG G +CIG+ LA+ E+ + L ++L PG+++ P+ L +H Sbjct: 339 LAFGFGAHQCIGQQLARIELQIVFETLFRRL-----PGLRLA-KPVEELRFRH 385 >4RM4-A nrPDB Length = 396 Score = 164 bits (415), Expect = 8e-41, Method: Composition-based stats. Identities = 57/326 (17%), Positives = 108/326 (33%), Gaps = 64/326 (19%) Query: 208 HFPESSDEMLSLVKNTHEF--VETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF-- 263 E +DE++ + EF V S P+ L +P+ +++FKA++ + Sbjct: 111 RIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKAWSDLLVSTPK 170 Query: 264 -----LQKTVQEHY---------------QDFDKNSVRDITGALFKHSKKGPRASGNLIP 303 +K E ++ +DI L + + +G + Sbjct: 171 DKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAEE-----TGEKLS 225 Query: 304 QEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRP 363 E+++ + AG +T T IS ++ ++ P + +++ Sbjct: 226 GEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELR------------------S 267 Query: 364 QLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWED 423 + + E R + P + RDT + G I + V N D ++ Sbjct: 268 HPELMPQAVEEALRFRAPAPV-LRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDR 326 Query: 424 PSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSV 483 P F R + FG G C+G LA+ E + L L+ Sbjct: 327 PHMFDIRR------------HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAF---- 370 Query: 484 PPGVKVDLTPIYGLTMKHARCEHVQA 509 P V +TPI + + V+ Sbjct: 371 PHMECVSITPIENSVIYGLKSFRVKM 396 >5XNT-A nrPDB Length = 411 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 63/362 (17%), Positives = 116/362 (32%), Gaps = 69/362 (19%) Query: 131 PVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYN 190 P RR L A S+ E + + A LI + E D Sbjct: 94 PEHRKRRSLLAAAFTPRSL---------QNWEPRIQEIADELIEEMDE----ETEIDIVQ 140 Query: 191 QVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPAL 250 + + ++ + G + ++V+ F P + Sbjct: 141 SLASPLPIIVMSDLMGVPSKDRL--------LFKKWVDIL-------FLPFDKEKQEEVN 185 Query: 251 QRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNL 310 + + + + +L V N DI L K G + +++V Sbjct: 186 ELKQVAAKEYYQYLYPIV----VQKRLNPADDIISDLLKA-----EVDGEMFTDDEVVRT 236 Query: 311 VNDIFGAGFDTVTTAISWSLMYLV-TKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLE 369 I GAG +T + ++ S L+ E+ +++ + LD V Sbjct: 237 TMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDLV------------------P 278 Query: 370 AFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRP 429 + E R+ F + + D L G + + V V N D E++ED Sbjct: 279 QAVEEMLRYR-FNLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMFEDAFTLNI 337 Query: 430 ERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE-FSVPPGVK 488 R P ++K + FG G C+G LA+ E + L L++ + P + Sbjct: 338 HR-----------PNNKKHLTFGNGPHFCLGAPLARLEAKIALTTFLKKFKHIEAVPSFQ 386 Query: 489 VD 490 ++ Sbjct: 387 LE 388 >5Y1I-A nrPDB Length = 403 Score = 163 bits (413), Expect = 2e-40, Method: Composition-based stats. Identities = 76/409 (18%), Positives = 126/409 (30%), Gaps = 78/409 (19%) Query: 77 QIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITD----GQSLTFSTDSGPV 132 +I GSTP +V D R L G D Y +F+ P Sbjct: 37 RIWDGSTPWVVTRHADQ-RALLSDPRVSHDGLRDGYPHISADFKFLSMAQPSFAGQDDPE 95 Query: 133 WAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQV 192 RR+ I + + K LI + +AGP D + Sbjct: 96 HGRIRRMVTLPFTARRI---------EAMRPAIQKITDELIDGM---LAGPKPVDLVEAL 143 Query: 193 VVSV-ANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQ 251 + V VI M P E L N + +TA YL Sbjct: 144 ALPVPVRVICEML---GVPYEDREFLQQNNNAMIYRDTAQGDAQKAAIAQAMYL------ 194 Query: 252 RFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLV 311 +E + DI L + G I Q+ + Sbjct: 195 -----------------KELVGTKLGDRGDDILSDLAVQVEAGE------ITQDDAAGIG 231 Query: 312 NDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAF 371 + GAG +T I+ + L+ PE +++ SD P++ + Sbjct: 232 MMLLGAGHETTANMIALGTLALLENPEQLAEVRD--------------SDDPKV--IVNT 275 Query: 372 ILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWED-PSEFRPE 430 + E R+ + T+ D + G I + N DP+L+ + P Sbjct: 276 VEELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDIH 335 Query: 431 RFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 R + + + FG G +C+G LA+ E+ + + LL+++ Sbjct: 336 R-----------ANARRHLAFGYGVHQCLGATLARVELQIVYSTLLRRI 373 >6GMF-A nrPDB Length = 397 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 69/424 (16%), Positives = 126/424 (29%), Gaps = 76/424 (17%) Query: 59 KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRP---DLYTST 115 +NP+ + + + V +++ + + R + + L F R L Sbjct: 14 RNPYALFAELRRT-SAVGRLQ--PQGFMAVGRYQDVARVLHD-AKGFSNRGWAASLPRGV 69 Query: 116 LITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISR 175 + P R L A ++A LE + A L+ Sbjct: 70 KWDTSMPPSIVQVDPPRHGKLRTLVTKAFTPRTVAQ---------LEPRIRDIAHELVDG 120 Query: 176 LQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNP 235 L+ + + + V + + PE + + + GN Sbjct: 121 LRGKSTFEATVEVTVPMPMIVIAEMLGVA-----PERRADFKRWSDDMVGSLALVRVGNA 175 Query: 236 LDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGP 295 + + Q F + + + ++ + D+ L Sbjct: 176 A---------------QLERSTQEFYAYFSEVL----EERRREPREDLISQLLAA----- 211 Query: 296 RASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRER 355 G + ++++ N + AG +T T+ I +L+ L PE Q +L V Sbjct: 212 EVDGEKLTAGEVLSFANTLLIAGNETTTSLIGNALVALTDHPEQLAAAQADLSLV----- 266 Query: 356 RPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVN 415 A + E R+ S I T D + IP + V N Sbjct: 267 -------------PAVVEEVLRYESPAQ-CIFRQTMTDVEIGDERIPARSVVLPLLASAN 312 Query: 416 HDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAIL 475 D + DP F R + FG+ CIG LA+ E + L +L Sbjct: 313 RDESRFPDPDRFDIHRDTK------------GHLAFGLDIHFCIGAPLARLEAKVMLEVL 360 Query: 476 LQQL 479 L +L Sbjct: 361 LARL 364 >2Z36-A nrPDB Length = 413 Score = 163 bits (411), Expect = 3e-40, Method: Composition-based stats. Identities = 51/289 (17%), Positives = 95/289 (32%), Gaps = 42/289 (14%) Query: 207 QHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQK 266 D+ML+ + + V+ S P L +P F++ + Sbjct: 128 DIVDHFIDDMLATDQRPVDLVQALSLPVPSLVICELLGVPYTDHDFFQSRTTMMVSRTSM 187 Query: 267 TVQEHYQDFDKNSVRDIT--------GALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAG 318 + + + D+ LF R G + +V+L + AG Sbjct: 188 EDRRRAFAELRAYIDDLITRKESEPGDDLFSRQIARQRQEGT-LDHAGLVSLAFLLLTAG 246 Query: 319 FDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRH 378 +T IS ++ L++ PE ++ + E R+ Sbjct: 247 HETTANMISLGVVGLLSHPEQLTVVKANPGR------------------TPMAVEELLRY 288 Query: 379 SSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGT 438 + T D + G I V V+ N DP +++DP+ ER Sbjct: 289 FTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVER------- 341 Query: 439 AINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQ---LEFSVP 484 + + FG G +C+G+ LA+ E+ + L ++ L +VP Sbjct: 342 -----GARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRIPSLRLAVP 385 >4YT3-A nrPDB Length = 410 Score = 163 bits (411), Expect = 3e-40, Method: Composition-based stats. Identities = 67/351 (19%), Positives = 113/351 (32%), Gaps = 68/351 (19%) Query: 131 PVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYN 190 P RR L A S+ E + + A LI M G D Sbjct: 94 PDHRKRRSLLAAAFTPRSL---------QNWEPRIQEIADELI----GQMDGGTEIDIVA 140 Query: 191 QVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPAL 250 + + ++ A G + ++V+T F P R Sbjct: 141 SLASPLPIIVMADLMGVPSKDRL--------LFKKWVDTL-------FLPFDREKQEEVD 185 Query: 251 QRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNL 310 + + + + +L V N DI L K G + +++V Sbjct: 186 KLKQVAAKEYYQYLYPIV----VQKRLNPADDIISDLLK-----SEVDGEMFTDDEVVRT 236 Query: 311 VNDIFGAGFDTVTTAISWSLMYLV-TKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLE 369 I GAG +T + ++ S L+ E+ +++ + LD V Sbjct: 237 TMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDLV------------------P 278 Query: 370 AFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRP 429 + E R F + + D L G + + V V N D E++EDP Sbjct: 279 QAVEEMLRFR-FNLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLNI 337 Query: 430 ERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480 R P ++K + FG G C+G LA+ E + L L++ + Sbjct: 338 HR-----------PNNKKHLTFGNGPHFCLGAPLARLEAKIALTAFLKKFK 377 >5IT1-A nrPDB Length = 399 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 54/293 (18%), Positives = 92/293 (31%), Gaps = 62/293 (21%) Query: 225 EFVETASSGNPLDFFPILRYLPNPALQRFKA-----------------FNQRFLWFLQKT 267 + V+T ++ P L +P F+ R L + Sbjct: 137 DLVKTFANPVPSMVISDLFGVPAERRAEFQEIAEAMMRVDQDAAATEAAGMRLGGLLYQL 196 Query: 268 VQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAIS 327 VQE N D+ AL +I ++N + A DT I Sbjct: 197 VQERRA----NPGDDLISALIT-----TEDPDGVIDDMFLMNAAGTLLIAAHDTTACMIG 247 Query: 328 WSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIP 387 L+ +P+ +QK+ + + E R+ + F Sbjct: 248 LGTALLLDRPDQLALLQKDP------------------SLIGNAVEELLRYLTIGQFGAE 289 Query: 388 HSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEK 447 T+D + G I K V + + DP EDP F R Sbjct: 290 RVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDITR------------RPAP 337 Query: 448 MMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMK 500 + FG G +CIG+ LA+ E+ + L ++ P +++ P+ L + Sbjct: 338 HLAFGFGAHQCIGQQLARIELQIVFGTLFRRF-----PTLRLA-KPVEELRFR 384 >4UBS-A nrPDB Length = 393 Score = 161 bits (407), Expect = 6e-40, Method: Composition-based stats. Identities = 65/414 (15%), Positives = 124/414 (29%), Gaps = 87/414 (21%) Query: 82 STPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG------QSLTFSTDSGPVWAA 135 V V++ R L Q L T+ + + P Sbjct: 36 GRSVWVVTGHAAARALLSDQ--RLSSDRTLPRFPATTERFEAVRTRRVALLGVDDPEHRT 93 Query: 136 RRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVS 195 +RR+ + + L + + L+ + E P + Sbjct: 94 QRRMLVPSFTL---------KRAAALRPRIQETVDGLLDAM-EAQGPPAELVSAFALP-L 142 Query: 196 VANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKA 255 + VI A+ L + H+F E+ S R L P + + Sbjct: 143 PSMVICAL-------------LGVPYADHDFFESQSR----------RLLRGPGIAEVQD 179 Query: 256 FNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIF 315 + +L + K + L + + + + + ++V+L + Sbjct: 180 ARAQLDDYLYALIDR----KRKEPGDGLLDDLIQ-----EQLNRGTVDRAELVSLATLLL 230 Query: 316 GAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILET 375 AG +T IS L+ PE +++ E + A + E Sbjct: 231 IAGHETTANMISLGTFTLLRHPEQLAELRAEPG------------------LMPAAVEEL 272 Query: 376 FRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTA 435 R S + T D + G I V +N D + +P R Sbjct: 273 LRFLSIAD-GLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHR---- 327 Query: 436 DGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKV 489 + + FG G +C+G+ LA+ E+ + L L ++L PG+++ Sbjct: 328 --------SARHHVAFGFGIHQCLGQNLARAEMEIALGTLFERL-----PGLRL 368 >6A7J-A nrPDB Length = 411 Score = 161 bits (407), Expect = 6e-40, Method: Composition-based stats. Identities = 51/269 (18%), Positives = 94/269 (34%), Gaps = 52/269 (19%) Query: 233 GNPLDFFPILRYLPNPALQRFKAFNQRFLWF-------------LQKTVQEHYQDFDKNS 279 P++ L + R K ++F L + ++ N Sbjct: 148 PLPMNVISELMGVDAADHPRLKELFEKFFSTQTPPEEVPQMMADLGTLFTKIVEEKKANP 207 Query: 280 VRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEI 339 D+T AL S+ G+ + E+I+N + I AG +T + I + L PE Sbjct: 208 GDDLTSALIAASE-----DGDHLTDEEILNTLQLIIAAGHETTISLIVNVVEALAIHPEQ 262 Query: 340 QRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGF 399 ++K+ ++P+ E I ET R ++ + T D + Sbjct: 263 RKKVLS-----------------GEIPW-EGVIEETLRWNTPTSHVLIRFATEDIEVGDK 304 Query: 400 YIPKKCCVFVNQWQVNHDPELW-EDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRC 458 +PK + V+ + D E + +F R + + FG G C Sbjct: 305 VLPKGEGLVVSFGALGRDEEQYGPTAGDFDATR------------TPNRHIAFGHGPHVC 352 Query: 459 IGEVLAKWEIFLFLAILLQQL---EFSVP 484 G L++ E + L L ++ + +VP Sbjct: 353 PGAALSRLEAGIALPALYERFPELDLAVP 381 >6A7I-A nrPDB Length = 411 Score = 161 bits (406), Expect = 9e-40, Method: Composition-based stats. Identities = 54/271 (19%), Positives = 95/271 (35%), Gaps = 52/271 (19%) Query: 231 SSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF-------------LQKTVQEHYQDFDK 277 + P++ L + R K ++F L + Sbjct: 146 AYPLPMNVISELMGVDAADHPRLKELFEKFFSTQTPPEEVPQMMADLGALFTKIVDAKRT 205 Query: 278 NSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKP 337 N D+T AL S+ +G+ + E+IVN + I AG +T + I + L T P Sbjct: 206 NPGDDLTSALIAASE-----NGDHLTDEEIVNTLQLIIAAGHETTISLIVNVVEALQTHP 260 Query: 338 EIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLN 397 E ++K+ L+ IG + I ET R ++ + T D + Sbjct: 261 EQRKKV---LNGEIG---------------WDGVIEETLRWNTPTSHVLIRFATEDIEVG 302 Query: 398 GFYIPKKCCVFVNQWQVNHDPELW-EDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKR 456 +PK + ++ + D E + EF R + + FG G Sbjct: 303 DKILPKGEGLIISFGALGRDEEQYGPTAGEFDATR------------TPNRHIAFGHGPH 350 Query: 457 RCIGEVLAKWEIFLFLAILLQQL---EFSVP 484 C G L++ E + L L ++ + +VP Sbjct: 351 VCPGAALSRLEAGIALPALYERFPELDLAVP 381 >3WVS-A nrPDB Length = 401 Score = 160 bits (404), Expect = 2e-39, Method: Composition-based stats. Identities = 49/300 (16%), Positives = 98/300 (32%), Gaps = 57/300 (19%) Query: 225 EFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF--------------LQKTVQE 270 + V + P L +P ++F + L L + Sbjct: 140 DLVADYALPIPTTVICELLGVPFEDREKFGRWTDAILSTSTLNPEEGRVKRMELVGYIGG 199 Query: 271 HYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSL 330 D+ + + R + + ++++++ + AG +T + I + Sbjct: 200 IIAARRAQPADDLISGMIEA-----RDVQDKLTEQELLDHCIGLLIAGHETTASQIPSFV 254 Query: 331 MYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLP-FTIPHS 389 L+ +P+ +++ + + + + + E FR P Sbjct: 255 YALLDQPQHWKRLLDDPE------------------LIPSAVEELFRFVPLGSGSAAPRY 296 Query: 390 TTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMM 449 D + G + V V N D +EDP E + +R S + Sbjct: 297 AREDIEVGGTLVRAGEPVLVALGAANRDGLRFEDPEEIKLDR------------PSNHHI 344 Query: 450 LFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKV--DLTPIYGLTMKHARCEHV 507 FG G C+G LA+ E+ L LL++L P +KV D+ + ++ R V Sbjct: 345 GFGHGIHHCLGAPLARLELQEALRALLERL-----PTLKVAGDIAWKSEMMVRGPRSMPV 399 >4JBT-A nrPDB Length = 410 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 73/431 (16%), Positives = 136/431 (31%), Gaps = 79/431 (18%) Query: 73 GDVLQIRIGSTPVLVLSRLDTIRQALVR-QGDDFKGRPDLYTSTLITDGQSLT------- 124 G + +I + P L ++ RQ L + L+ S +T L Sbjct: 30 GPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDINAWSLWQSGTVTRQWPLIGMIDVDR 89 Query: 125 -FSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGP 183 T GP R AL + + L+ + + L+ L+ A Sbjct: 90 SMFTVDGPEHRRLRIKTTQALTRRRLDA---------LKPTIERYVAELLDDLERAGADG 140 Query: 184 GHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILR 243 D + + + + G E +++L+ K + Sbjct: 141 AVVDLKSVFAYPLPMRVISALMGVP-SEDQEQLLTWYKAFFSIL---------------- 183 Query: 244 YLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIP 303 P +R + + + E + D+T AL + + Sbjct: 184 ---TPQDERLR-----VIDEMHGYFTEMVRRKTAEPGDDLTSALIYATDGE-----TPLT 230 Query: 304 QEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRP 363 +E+++ + + AG +T + I ++ L++ PE R ++ D IG Sbjct: 231 EEEVIGNLQALVAAGHETTVSLILTAVRALLSHPEQLRLVR---DGEIG----------- 276 Query: 364 QLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELW-E 422 E I ET R + + T D L IP+ V ++ + D + Sbjct: 277 ----WETAIEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVHGA 332 Query: 423 DPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482 D +F R + + + FG G C G LA+ E + L L + Sbjct: 333 DADDFDITR-----------ATAARHISFGHGPHICPGAALARLEAAIALPALFTRFP-H 380 Query: 483 VPPGVKVDLTP 493 + P + +D P Sbjct: 381 LHPALPLDQIP 391 >4WPZ-A nrPDB Length = 397 Score = 158 bits (400), Expect = 4e-39, Method: Composition-based stats. Identities = 58/290 (20%), Positives = 95/290 (32%), Gaps = 54/290 (18%) Query: 217 LSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQ------- 269 L + + V+ S P+ L +P F A++ L Q+ V+ Sbjct: 124 LETLPRPVDLVKNFSVPLPVRVICELLGVPAGDQDTFHAWSNALLGDWQQVVEKEAATVS 183 Query: 270 ------EHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVT 323 E +N D+ L S + + + +I+ L I AG +T Sbjct: 184 LVNYFGELIAVKRENPADDLISELIAISDGD-----STLTEREIIALSIGILSAGHETTA 238 Query: 324 TAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLP 383 IS L+ L+ PE K++ + + + E R Sbjct: 239 NQISMFLVTLLHNPEELDKLRDNREAI------------------PKAVDELLRFVPLTT 280 Query: 384 FT--IPHSTTRDTTL-NGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAI 440 IP TT + L G +P V N DPE++ED R Sbjct: 281 TGGIIPRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLNVTR--------- 331 Query: 441 NKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL---EFSVPPGV 487 + + FG G C+G LA+ E+ L +L ++ +VP Sbjct: 332 ---ENNPHLAFGAGIHHCLGAQLARIELQEALGAILDRMPQVRLAVPESE 378 >4YZR-A nrPDB Length = 405 Score = 158 bits (400), Expect = 5e-39, Method: Composition-based stats. Identities = 43/297 (14%), Positives = 102/297 (34%), Gaps = 55/297 (18%) Query: 221 KNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF--------------LQK 266 +N + +++ +S P L +P +F+ + + + Sbjct: 136 ENKADIMKSFASPLPFIVISELMGIPKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKD 195 Query: 267 TVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAI 326 + + D D+ L + +G+ + ++++ +++ + AG +T + Sbjct: 196 YIAKLIHDRRIKPKDDLISKLVHAEE-----NGSKLSEKELYSMLFLLVVAGLETTVNLL 250 Query: 327 SWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTI 386 + L+ + K++++ + + + E R++S + Sbjct: 251 GSGTLALLQHKKECEKLKQQPEMIA------------------TAVEELLRYTSPVVMMA 292 Query: 387 PHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSE 446 D T G I + +F+ N DP +E+P R Sbjct: 293 NRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILNINR------------SPN 340 Query: 447 KMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL---EFSVPPGVKVDLTPIYGLTMK 500 + + FG G C+G LA+ E + LL++ E +V P D+ + ++ Sbjct: 341 RHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPD---DIQWRKNVFLR 394 >1EHE-A nrPDB Length = 403 Score = 158 bits (399), Expect = 6e-39, Method: Composition-based stats. Identities = 73/451 (16%), Positives = 141/451 (31%), Gaps = 89/451 (19%) Query: 58 GKNPHLALSRMSQRYGDVLQIRIG----------STPVLVLSRLDTIRQALVRQG-DDFK 106 G P +++ V Q+++ V ++ + + + RQG + Sbjct: 15 GPEPPAEFAKLRAT-NPVSQVKLFDGSLAWLVTKHKDVCFVATSEKLSKVRTRQGFPELS 73 Query: 107 GRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVS 166 T F P +R + + + L+ ++ Sbjct: 74 ASGKQAAKAKPT------FVDMDPPEHMHQRSMVEPTFTP---------EAVKNLQPYIQ 118 Query: 167 KEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEF 226 + L+ ++++ G D + + V + I G F + E L+ Sbjct: 119 RTVDDLLEQMKQKGCANGPVDLVKEFALPVPSYIIYTLLGVPF--NDLEYLTQQNAIRTN 176 Query: 227 VETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGA 286 + + + A NQ L +L V++ + DI Sbjct: 177 GSSTA-------------------REASAANQELLDYLAILVEQRLVE----PKDDIISK 213 Query: 287 LFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKE 346 L K I + V + + AG T+ I+ + L P+ +++ Sbjct: 214 LCTEQVKPGN-----IDKSDAVQIAFLLLVAGNATMVNMIALGVATLAQHPDQLAQLKAN 268 Query: 347 LDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCC 406 F+ E R+ + I + D + + Sbjct: 269 P------------------SLAPQFVEELCRYHTASALAIKRTAKEDVMIGDKLVRANEG 310 Query: 407 VFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKW 466 + + N D E++E+P EF R K + + FG G RCI E LAK Sbjct: 311 IIASNQSANRDEEVFENPDEFNMNR----------KWPPQDPLGFGFGDHRCIAEHLAKA 360 Query: 467 EIFLFLAILLQQL---EFSVPPGVKVDLTPI 494 E+ + L Q+ + +VP G K++ TP+ Sbjct: 361 ELTTVFSTLYQKFPDLKVAVPLG-KINYTPL 390 >3P3Z-A nrPDB Length = 416 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 55/295 (18%), Positives = 101/295 (34%), Gaps = 44/295 (14%) Query: 205 FGQHFPESSDE--MLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLW 262 F QHFP M L+ E +T + + L + + R Sbjct: 149 FVQHFPHPLPALVMCQLLGFPLEDYDTVGRLSIETNLGLALSNDQDILVKVEQGLGRMFD 208 Query: 263 FLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 322 +L +++ + D+T + + G ++ ++ LV + AG++T Sbjct: 209 YLVAAIEKRKVE----PGDDLTSDIVRAFHDG------VLDDYELRTLVATVLVAGYETT 258 Query: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 382 ++ ++ P+ KI++ + + E R S L Sbjct: 259 NHQLALAMYDFAQHPDQWMKIKENPE------------------LAPQAVEEVLRWSPTL 300 Query: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442 P T D +NG IP VF+ + DP ++ D F Sbjct: 301 PVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADADRFDIT-----------V 349 Query: 443 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGL 497 + FG G C+G LA+ E+ +A L +L+ PP + ++T + L Sbjct: 350 KREAPSIAFGGGPHFCLGTALARLELTEAVAALATRLD---PPQIAGEITWRHEL 401 >1CPT-A nrPDB Length = 428 Score = 154 bits (389), Expect = 9e-38, Method: Composition-based stats. Identities = 75/421 (17%), Positives = 136/421 (32%), Gaps = 75/421 (17%) Query: 71 RYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSG 130 ++ DV ++IG P L + + + L Q ++ R I+ G + + Sbjct: 56 KHADV--MQIGKQPGLFSNAEGS--EILYDQNNEAFMRS-------ISGGCPHVIDSLTS 104 Query: 131 ---PVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFD 187 P A R L N SI LEE++ + A+A + RL + + Sbjct: 105 MDPPTHTAYRGLTLNWFQPASIRK---------LEENIRRIAQASVQRLLDFDG-----E 150 Query: 188 PYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPN 247 ++ + + PE + ++ + V P Sbjct: 151 CDFMTDCALYYPLHVVMTALGVPEDDEPLMLKLTQDFFGVHEPDEQAVAA--------PR 202 Query: 248 PALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKI 307 + + D D+ L + GN I + I Sbjct: 203 QSADEAARRFHETIATFYDYFNGFTVDRRSCPKDDVMSLL-----ANSKLDGNYIDDKYI 257 Query: 308 VNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPY 367 I AG DT +++ +++ L PE + Sbjct: 258 NAYYVAIATAGHDTTSSSSGGAIIGLSRNPEQLA------------------LAKSDPAL 299 Query: 368 LEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEF 427 + + E R ++ + + + DT + G I + + ++ N D E++ +P EF Sbjct: 300 IPRLVDEAVRWTAPVK-SFMRTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEF 358 Query: 428 RPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL---EFSVP 484 RF + + FG G C+G+ LAK E+ +F LL +L E S P Sbjct: 359 DITRF------------PNRHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSGP 406 Query: 485 P 485 P Sbjct: 407 P 407 >4MM0-A nrPDB Length = 399 Score = 154 bits (389), Expect = 1e-37, Method: Composition-based stats. Identities = 65/407 (15%), Positives = 135/407 (33%), Gaps = 91/407 (22%) Query: 82 STPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQ 141 P +++R + +R L F R DL + +T+ + T PV RRL Sbjct: 44 GDPGFLVTRYEDVRFVLSDP--RFSVRQDLPGAPRLTEMTFESVMTTDPPVHTRLRRL-- 99 Query: 142 NALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIG 201 ++ D + + + + A+ L+ +++ A Sbjct: 100 -------LSRDFTARRIERMRPRLEEIAEGLLDEMEKKGA-------------------- 132 Query: 202 AMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRF- 260 + VE+ + P+ L +P + RF+ + Sbjct: 133 ---------------------PADIVESLAVPFPITVICELLGVPMVDVARFRGWADTMV 171 Query: 261 --------LWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVN 312 W + E Y D + R+ G+ + A N + + +L Sbjct: 172 SLTGYSMEDWTAARDALESYLDGLVAAKRENPGSDLLSALVATAAEDNELTDHDVRSLSL 231 Query: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 372 + AG++ + + S++ L+ P+ +++++ L + + Sbjct: 232 ILLLAGYEPASNQLGSSVLTLLRFPDRLAELRRDPG------------------LLPSAV 273 Query: 373 LETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432 E R++ + T D T+ +IP V + N DP ++DP+ R +R Sbjct: 274 EELMRYAPAGDGALFRVTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTGLRLDR- 332 Query: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 + G G C+G LA+ E+ + + LL++ Sbjct: 333 -----------PDNQHTALGHGIHFCLGAALARVELQVAIGALLRRF 368 >4Z5P-A nrPDB Length = 400 Score = 154 bits (388), Expect = 1e-37, Method: Composition-based stats. Identities = 43/336 (12%), Positives = 97/336 (28%), Gaps = 62/336 (18%) Query: 192 VVVSVANVIGAMCFGQHFPESSDEMLSLVKNTH------EFVETASSGNPLDFFPILRYL 245 + ++ A G + L+ + V + + L + Sbjct: 97 LRRLLSKAFTARRMGAMQSWLEELFAGLLDGVERTGHPADIVRDLAQPFTIAVICRLLGV 156 Query: 246 PNPALQRFKAFNQRFLWF--------------LQKTVQEHYQDFDKNSVRDITGALFKHS 291 P RF+ +++ + ++ + + D+ G L Sbjct: 157 PYEDRGRFQHWSEVIMSTTAYSKEEAVSADASIRAYLADLVSARRAAPHDDLLGVLVSA- 215 Query: 292 KKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVI 351 R + + +++++ + AG +T + + L+T + ++++ + Sbjct: 216 ----RDDDDRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSLLREQPE--- 268 Query: 352 GRERRPRLSDRPQLPYLEAFILETFRHSSFLP-FTIPHSTTRDTTLNGFYIPKKCCVFVN 410 L + E R D L+G + V Sbjct: 269 ---------------LLPRAVEELLRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAA 313 Query: 411 QWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFL 470 N DP ++DP R + FG G C+G LA+ E+ + Sbjct: 314 AVNANRDPRAFDDPDRLDITR------------EKNPHLAFGHGAHYCLGAQLARMELRV 361 Query: 471 FLAILLQQL---EFSVPPGVKVDLTPIYGLTMKHAR 503 + LL++ +VP + G + + Sbjct: 362 AIGGLLERFPGLRLAVPADQ---VEWKTGGLFRGPQ 394 >3A50-A nrPDB Length = 411 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 80/437 (18%), Positives = 143/437 (32%), Gaps = 79/437 (18%) Query: 56 TLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALV--RQGDDFKGR-PDLY 112 T +NPH A + + V ++ + PV +L+R +R+A V R D++ R P+ Sbjct: 17 TFWQNPHPAYAALRAE-DPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHRLPEDQ 75 Query: 113 TSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKAL 172 + + + D P R+L + + LE +++ A L Sbjct: 76 RADMPATPTPMMILMDP-PDHTRLRKLVGRSFTVRRMNE---------LEPRITEIADGL 125 Query: 173 ISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASS 232 ++ L GP VI + G + D + Sbjct: 126 LAGLP--TDGPVDL-MREYAFQIPVQVICELL-GLPAEDRDD--------FSAWSSVLVD 173 Query: 233 GNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSK 292 +P D A + +L ++ + D AL Sbjct: 174 DSPAD--------------DKNAAMGKLHGYLSDLLERKRTEPD--------DALLSSLL 211 Query: 293 KGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG 352 G+ + QE++V + + AG +T I ++ L+T P+ QRK+ E ++I Sbjct: 212 AVSDMDGDRLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPD-QRKLLAEDPSLIS 270 Query: 353 RERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQW 412 + E R S + T D T +G IP V + Sbjct: 271 S-----------------AVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLA 313 Query: 413 QVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFL 472 N D + +P R + + FG G C+G LA+ E + + Sbjct: 314 AANRDADWMPEPDRLDITRD------------ASGGVFFGHGIHFCLGAQLARLEGRVAI 361 Query: 473 AILL-QQLEFSVPPGVK 488 L + E ++ G+ Sbjct: 362 GRLFADRPELALAVGLD 378 >6HQG-A nrPDB Length = 425 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 64/386 (16%), Positives = 122/386 (31%), Gaps = 65/386 (16%) Query: 103 DDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLE 162 + F P + D F P +R+ Q + + YLE Sbjct: 80 EVFSSEPTIVLPDPADDFTLPMFIAMDPPKHDVQRKTVQPIVAP---------NHLAYLE 130 Query: 163 EHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKN 222 + + A ++ L + ++V + + + A F FP L+ + Sbjct: 131 PIIRERAGKILDDLP----IGEEINWVDKVSIELTTMTLATLF--DFPWEDRRKLTFWSD 184 Query: 223 THEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRD 282 + D P + + + + E + D Sbjct: 185 VATSAPESGILGTTD--------PEEHENLRRQTLFECVDYFMRLWNERV---NAPPKPD 233 Query: 283 ITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRK 342 + L S + + + + + + G DT IS S++ L P+ RK Sbjct: 234 LISML------AHGESTKNMDRMEYLGNLILLIVGGNDTTRNTISGSVLALHQNPDQDRK 287 Query: 343 IQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIP 402 +++ + A + ET R + L + + RD L G I Sbjct: 288 LRENPG------------------LIPAMVSETIRWQTPLAY-MRRRAKRDFELGGKTIR 328 Query: 403 KKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEV 462 + V + N D E+ + P+++ ER P + + FG G RC+G Sbjct: 329 EGDKVAMWYVSGNRDEEVIDRPNDYWIER-----------PRVRQHLSFGFGVHRCVGNR 377 Query: 463 LAKWEIFLFLAILLQQL---EFSVPP 485 LA+ ++ + +L + E PP Sbjct: 378 LAELQLKIIWEEILARFPRLEVVGPP 403 >5YSW-A nrPDB Length = 441 Score = 151 bits (382), Expect = 5e-37, Method: Composition-based stats. Identities = 72/429 (16%), Positives = 133/429 (31%), Gaps = 87/429 (20%) Query: 73 GDVLQIRIG-STPVLVLSRLDTIRQALVR---QGDDFKGRP-------DLYTSTLITDGQ 121 G V + + P ++S + R L D F+ P + + Sbjct: 64 GPVARATLAAGDPFWLVSGYEEARAVLSDPRFSSDRFQYHPWFKELSPEFRERLRDDKAR 123 Query: 122 SLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMA 181 + +F P R+L I A ++E V+ R+ ++A Sbjct: 124 AGSFINMDPPEHTRYRKLLTGQFTVRRIRELGAR-----IDEIVA-------GRVDAMLA 171 Query: 182 GPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPI 241 G D + +++ G + + ++ Sbjct: 172 GGTTADLMTEFAFPAPSLMICELLGVRYEDRAEFQQRASALLQMN--------------- 216 Query: 242 LRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNL 301 P + K + L+ +Q D N DI L H+ P Sbjct: 217 -----APVAEAVKNADA-----LRAFMQALVTDKRANPAGDIISGLIHHAGADPA----- 261 Query: 302 IPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSD 361 + ++++N+ N + AG+DT + + + L+ +P ++ + + Sbjct: 262 LTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDDPSRIAD--------- 312 Query: 362 RPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELW 421 + E R+ S + I D G +IP V V+ N D W Sbjct: 313 ---------AVEELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHW 363 Query: 422 EDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL-- 479 DP R + FG G +C+G+ LA+ E+ A LL++L Sbjct: 364 PDPD-LDLTR------------PRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPN 410 Query: 480 -EFSVPPGV 487 +VPP Sbjct: 411 VRLAVPPEE 419 >6FYJ-A nrPDB Length = 421 Score = 151 bits (381), Expect = 7e-37, Method: Composition-based stats. Identities = 64/441 (14%), Positives = 143/441 (32%), Gaps = 65/441 (14%) Query: 51 LGHVLTLGKNPHLALSRMSQRY-GDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRP 109 + L + ++ + + D+ + R+ + + + + + FK + Sbjct: 15 IDSTWRLMEEGYMYILNRRHSFNSDIFETRLLGKKAICMGGKEAA-EIFYDT-EKFKRKD 72 Query: 110 DLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEA 169 + T G R+ + + ++ + L + K+ Sbjct: 73 AAPNRVVQTLFGKNGVQALDGQTHKHRKEMFMSIMSPDELEK---------LTDITKKQW 123 Query: 170 KALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVET 229 + + + +++ Y + + P +E+ L KN E+ Sbjct: 124 EIAVDKWEQMD----KVILYEEAKEIMCRTACQWA---GVPVQENEVKRLTKNLGAMFES 176 Query: 230 ASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFK 289 A++ + ++++ + + +D N + T Sbjct: 177 AAAV-------------GLKHWLGRHARNYEEIWIEELI-DRVRDGKVNPPENTT---LH 219 Query: 290 HSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDT 349 GNL+ E V +I + I++ + L PE + K++ Sbjct: 220 KFSWYRDLEGNLLDTETAAVEVINILRPIV-AIAIFINFIALALHHYPEEKEKLKS---- 274 Query: 350 VIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFV 409 Y + F+ E R F PF + +D T G+ + + Sbjct: 275 -------------GDKKYSQMFVQEVRRFYPFFPFVVA-LVKKDFTWKGYKFEEGTLTLL 320 Query: 410 NQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK----RRCIGEVLAK 465 + + NHDPE+W++P F P+RF +G+ + + G G RC GE + Sbjct: 321 DLYGTNHDPEIWKNPDVFSPDRFAKWEGSPFS------FIPQGGGDYFMGHRCAGEWVTI 374 Query: 466 WEIFLFLAILLQQLEFSVPPG 486 + + L L ++++ VP Sbjct: 375 EVMKVSLDYLTNRMDYEVPDQ 395 >5XW2-A nrPDB Length = 419 Score = 151 bits (381), Expect = 8e-37, Method: Composition-based stats. Identities = 65/369 (17%), Positives = 114/369 (30%), Gaps = 62/369 (16%) Query: 131 PVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYN 190 P R+L +A LE ++ + L+ + + Sbjct: 100 PDHRELRKLVSHAFTP---------KVVAELEPRITALTQELLDAVADRDTFDLMTALAY 150 Query: 191 QVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPAL 250 + V+V E+LS+ E + + Sbjct: 151 PLPVTVV----------------AELLSIPSADRHLFEGWMTEIVHSLGDVSMEDAPEDQ 194 Query: 251 QRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNL 310 +R + + + ++EH + + D+ G L + G + IVN Sbjct: 195 ERIFEAGMAPMRKMLEYLREHAAECRRRPRGDLMGKLIEA-----EVDGRRLTDNHIVNF 249 Query: 311 VNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEA 370 + AG+ T T I +++ L + PE +++ DR +P L Sbjct: 250 AKMLLIAGYLTTTMLIGNTVLCLDSYPEQAARVRA---------------DRSLIPGL-- 292 Query: 371 FILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPE 430 + E+ R S + +TTRD + G + V V N D + +P F Sbjct: 293 -LEESMRFLSPVA-ATYRATTRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPELFDMT 350 Query: 431 RFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL-EFSVPPGVKV 489 R + FG G C+G LA+ E + L LL + E P Sbjct: 351 R------------GPNPHLGFGRGIHFCLGGPLARMEGRVALDHLLDRFPELYTDPERPP 398 Query: 490 DLTPIYGLT 498 P + T Sbjct: 399 TFMPGFDTT 407 >5HDI-A nrPDB Length = 404 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 52/273 (19%), Positives = 103/273 (37%), Gaps = 43/273 (15%) Query: 219 LVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKN 278 + E++ ++ P+ L LP+P + + + L+ V+ Sbjct: 133 MQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGV 192 Query: 279 SVRDITGALFKHSKKGPRASGNLIPQEKIVN-------------LVNDIFGAGFDTVTTA 325 ++ +++G +F+ + + + E ++ +F AG ++ Sbjct: 193 ALMELSGYIFEQFDRAAADPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGESTAAL 252 Query: 326 ISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFT 385 + ++ L T+P+IQ++++ + L AFI ET R+ Sbjct: 253 LGSAVWILATRPDIQQQVRANPE------------------LLGAFIEETLRYEPPFRGH 294 Query: 386 IPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLS 445 H TTL+G +P + + N DP +E P EFR +R Sbjct: 295 YRHVRNA-TTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDR-----------AGG 342 Query: 446 EKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQ 478 + + FG G C+G LA+ E + L +LL + Sbjct: 343 KGHISFGKGAHFCVGAALARLEARIVLRLLLDR 375 >6GK6-A nrPDB Length = 411 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 49/271 (18%), Positives = 93/271 (34%), Gaps = 51/271 (18%) Query: 225 EFVETASSGNPLDFFPILRYLPNPALQRFKAFN---------QRFLWFLQKTVQEHYQDF 275 E + + P L LP RF+ + + F+ Q V+E F Sbjct: 140 ELIADFAFPLPTAVIAELLGLPVEDRGRFRRWTKILLAPAKDREFVERAQPVVEEFAAYF 199 Query: 276 D-------KNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISW 328 K D+ L ++ + + ++ ++V + AG +T I+ Sbjct: 200 RALADARRKAPRDDLISGLLLAEEQEHK-----LSPAELSSMVFLLLVAGHETTVHLIAS 254 Query: 329 SLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPH 388 ++ L++ P +R++ ++ V + + E R + Sbjct: 255 GMLLLLSHPAERRRLDEDPGLV------------------GSAVEEALRCEGPAELSTIR 296 Query: 389 STTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKM 448 + D L G +P V N DP+ + DP F R + Sbjct: 297 WSLEDIELFGARVPAGEGVAAGLLAANRDPQHFPDPDRFDIGR------------SPNRH 344 Query: 449 MLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 + FG G C+G +LA+ E + + LL++L Sbjct: 345 IGFGGGIHFCLGAMLARIEAAIAFSTLLRRL 375 >4OQS-A nrPDB Length = 433 Score = 150 bits (378), Expect = 2e-36, Method: Composition-based stats. Identities = 61/411 (14%), Positives = 122/411 (29%), Gaps = 95/411 (23%) Query: 87 VLSRLDTIRQALVRQGDDFKGRPD----LYTSTLITDGQSLT-----FSTDSGPVWAARR 137 +++ R ++ F RP+ +++ G + F P R Sbjct: 49 LVTSHAAARTVMIDP--RFSNRPEHKHPVFSVIPRPGGATKAPAPGWFINMDAPEHTRYR 106 Query: 138 RLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVA 197 R+ + I LE + + + + + + P + V + Sbjct: 107 RMLISQFTVRRIKE---------LEPRIVQITEDHLDAMAK-AGPPVDLVQAFALPV-PS 155 Query: 198 NVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFN 257 VI + + V+ + + Sbjct: 156 LVICELL---GVSYADHAFFQEQTTIMASVD-----------------------KTQDEV 189 Query: 258 QRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGA 317 L L + + E + D+ G+L + + E++ N+ + A Sbjct: 190 TTALGKLTRYIAELVATKRLSPKDDLLGSLI---------TDTDLTDEELTNIALLLLVA 240 Query: 318 GFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFR 377 G +T + L+ PE + D P + E R Sbjct: 241 GHETTANMLGLGTFALLQHPEQIAAL-----------------DSPD------AVEELLR 277 Query: 378 HSSFLPFTIP-HSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTAD 436 + S + P + D L G I K V + VN DP+++++P + +R Sbjct: 278 YLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDRVD--- 334 Query: 437 GTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL---EFSVP 484 + K FG G +C+G+ LA+ E+ + L + +VP Sbjct: 335 --------ARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVP 377 >2WIO-A nrPDB Length = 431 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 47/292 (16%), Positives = 89/292 (30%), Gaps = 54/292 (18%) Query: 208 HFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF---- 263 + + +L+ + + V+ + P+ L LP ++F ++ + Sbjct: 137 RIRDVTRSLLADAGESFDLVDVLAFPLPVTIVAELLGLPPMDHEQFGDWSGALVDIQMDD 196 Query: 264 ----------------LQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKI 307 L ++ + + D+ L G + E+ Sbjct: 197 PTDPALAERIADVLNPLTAYLKARCAERRADPGDDLISRLVLA-----EVDGRALDDEEA 251 Query: 308 VNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPY 367 N + AG T T + + L P ++ + Sbjct: 252 ANFSTALLLAGHITTTVLLGNIVRTLDEHPAHWDAAAEDPGRI----------------- 294 Query: 368 LEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEF 427 A + E R+ P + +TT+ T + G IP V N D + +DP F Sbjct: 295 -PAIVEEVLRYRPPFP-QMQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRF 352 Query: 428 RPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 P R K + FG G C+G LA+ E + L ++ + Sbjct: 353 DPSR----------KSGGAAQLSFGHGVHFCLGAPLARLENRVALEEIIARF 394 >3R9C-A nrPDB Length = 418 Score = 149 bits (376), Expect = 3e-36, Method: Composition-based stats. Identities = 60/362 (16%), Positives = 115/362 (31%), Gaps = 55/362 (15%) Query: 148 SIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207 + + + + + + + E AL+ +L + + GP N VI + Sbjct: 107 RLRGLVSKAFAPRVIKRLEPEITALVDQLLDAVDGPEFNLIDNLAYPLPVAVICRLLGVP 166 Query: 208 HFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKT 267 E S + A +G D F +L+ Sbjct: 167 IEDEPKFSRASALLAAALDPFLALTGETSDLF-----------DEQMKAGMWLRDYLRAL 215 Query: 268 VQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAIS 327 + E + D+ L + SG+ + +++I+ N + AG +T I+ Sbjct: 216 IDERRRT----PGEDLMSGLVAVEE-----SGDQLTEDEIIATCNLLLIAGHETTVNLIA 266 Query: 328 WSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIP 387 + + ++ P + + A I ET R+ + + Sbjct: 267 NAALAMLRTPGQWAALAADGSR------------------ASAVIEETMRYDPPVQL-VS 307 Query: 388 HSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEK 447 D T+ +PK + + + DP + P F P+R + Sbjct: 308 RYAGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPDR------------AQIR 355 Query: 448 MMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL---EFSVPPGVKVDLTPIYGLTMKHARC 504 + FG G C+G LA+ E + L L + S P K +LT + G++ Sbjct: 356 HLGFGKGAHFCLGAPLARLEATVALPALAARFPEARLSGEPEYKRNLT-LRGMSTLSIAV 414 Query: 505 EH 506 H Sbjct: 415 HH 416 >4OQR-A nrPDB Length = 457 Score = 148 bits (374), Expect = 5e-36, Method: Composition-based stats. Identities = 61/411 (14%), Positives = 123/411 (29%), Gaps = 95/411 (23%) Query: 87 VLSRLDTIRQALVRQGDDFKGRPD----LYTSTLITDGQSLT-----FSTDSGPVWAARR 137 +++ R ++ F RP+ +++ G + F+ P R Sbjct: 88 LVTSHAAARTVMIDP--RFSNRPEHKHPVFSVIPRPGGATKAPAPGWFTNMDAPEHTRYR 145 Query: 138 RLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVA 197 R+ + I LE + + + + + + P + V + Sbjct: 146 RMLISQFTVRRIKE---------LEPRIVRITEDHLDAMAK-AGPPVDLVQAFALPV-PS 194 Query: 198 NVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFN 257 VI + + V+ + + Sbjct: 195 LVICELL---GVSYADHAFFQEQTTIMVSVD-----------------------KTQDEV 228 Query: 258 QRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGA 317 L L + + E + D+ G+L + + E++ N+ + A Sbjct: 229 TTALGKLTRYIAELVATKRLSPKDDLLGSLI---------TDTDLTDEELTNIALILLVA 279 Query: 318 GFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFR 377 G +T + L+ PE + D P + E R Sbjct: 280 GHETTANMLGLGTFALLQHPEQIANL-----------------DSPD------AVEELLR 316 Query: 378 HSSFLPFTIP-HSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTAD 436 + S + P + D L G I K V + VN DP+++++P + +R Sbjct: 317 YLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDRVD--- 373 Query: 437 GTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL---EFSVP 484 + K FG G +C+G+ LA+ E+ + L + +VP Sbjct: 374 --------ARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVP 416 >3TYW-A nrPDB Length = 417 Score = 148 bits (373), Expect = 6e-36, Method: Composition-based stats. Identities = 71/398 (17%), Positives = 131/398 (32%), Gaps = 78/398 (19%) Query: 87 VLSRLDTIRQALVR-QGDDFKGRPDLYTSTLITDGQSLTFST---DSGPVWAARRRLAQN 142 V++R D +R+ L + RP F P RR+ Sbjct: 57 VVTRYDDVRELLSDPRVSADIRRPGFPALGEGEQEAGARFRPFIRTDAPEHTRYRRMLLP 116 Query: 143 ALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVA-NVIG 201 A + ++ V L ++A G D + +V+ +VI Sbjct: 117 AF-----TVRRVRAMRPAVQARVD-------EILDGMLAAGGPVDLVSAYANAVSTSVIC 164 Query: 202 AMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFL 261 E+L + ++ EF + + N ++ Sbjct: 165 -------------ELLGIPRHDLEFFRDVTRISGSR---------NSTAEQVSEALGGLF 202 Query: 262 WFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDT 321 L V E ++ D+ L GN+ ++ +++ + AG +T Sbjct: 203 GLLGGLVAERREE----PRDDLISKLVT----DHLVPGNVTTEQ-LLSTLGITINAGRET 253 Query: 322 VTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSF 381 T+ I+ S + L+ +PE+ +++K+ D + A + E R S Sbjct: 254 TTSMIALSTLLLLDRPELPAELRKDPD------------------LMPAAVDELLRVLSV 295 Query: 382 LPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAIN 441 D L+G +P V NHDPE ++DP R Sbjct: 296 ADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHR---------- 345 Query: 442 KPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 + FG G +C+G+ LA+ E+ + L LL+++ Sbjct: 346 --TDNHHVAFGYGVHQCVGQHLARLELEVALETLLRRV 381 >5XJN-A nrPDB Length = 455 Score = 148 bits (373), Expect = 6e-36, Method: Composition-based stats. Identities = 81/458 (17%), Positives = 145/458 (31%), Gaps = 97/458 (21%) Query: 60 NPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYT------ 113 NP A + Q + RIG V+++ D I+ + F Sbjct: 63 NPFPAYKELRQEEPVMFDERIGYW---VVTKYDDIKTTF-DDWETFSSENAQAPVRKRGP 118 Query: 114 --STLITDGQSLTFSTDSG---PVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKE 168 + ++TDG +S S P R +AQ A + + V Sbjct: 119 QATQIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTP-----RRYKALEPDIRAMVIDR 173 Query: 169 AKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVE 228 + +++ Q + Y+ +++ +IGA S+V + + Sbjct: 174 VEKMLANDQHVGDMVSDL-AYDIPTITILTLIGADI-------------SMVDTYKRWSD 219 Query: 229 TASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALF 288 + ++ D + P + Q Q D + ++T L Sbjct: 220 SRAAMTWGDLSDEEQI---PHAHNLVEYWQEC--------QRMVADAHAHGGDNLTADLV 268 Query: 289 KHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELD 348 + + G I +I +L+ + AG +T TT IS L+ PE + I + Sbjct: 269 RA-----QQEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILENPK 323 Query: 349 TVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVF 408 + A + E R+S + +DT + G I + V Sbjct: 324 ------------------LIPAAVDEVLRYSGSI-VGWRRKALKDTEIGGVAIKEGDGVL 364 Query: 409 VNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEI 468 + N D +E+ EF R + + + FG G C+G +LAK + Sbjct: 365 LLMGSANRDEARFENGEEFDISR-----------ANAREHLSFGFGIHYCLGNMLAKLQA 413 Query: 469 FLFLAILLQ-----------------QLEFSVPPGVKV 489 + L + + L F VP V V Sbjct: 414 KICLEEVTRLVPSLHLVADKAIGFRENLSFRVPTSVPV 451 >5GWE-A nrPDB Length = 405 Score = 147 bits (372), Expect = 8e-36, Method: Composition-based stats. Identities = 81/458 (17%), Positives = 145/458 (31%), Gaps = 97/458 (21%) Query: 60 NPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYT------ 113 NP A + Q + RIG V+++ D I+ + F Sbjct: 13 NPFPAYKELRQEEPVMFDERIGYW---VVTKYDDIKTTF-DDWETFSSENAQAPVRKRGP 68 Query: 114 --STLITDGQSLTFSTDSG---PVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKE 168 + ++TDG +S S P R +AQ A + + V Sbjct: 69 QATQIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTP-----RRYKALEPDIRAMVIDR 123 Query: 169 AKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVE 228 + +++ Q + Y+ +++ +IGA S+V + + Sbjct: 124 VEKMLANDQHVGDMVSDL-AYDIPTITILTLIGADI-------------SMVDTYKRWSD 169 Query: 229 TASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALF 288 + ++ D + P + Q Q D + ++T L Sbjct: 170 SRAAMTWGDLSDEEQI---PHAHNLVEYWQEC--------QRMVADAHAHGGDNLTADLV 218 Query: 289 KHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELD 348 + + G I +I +L+ + AG +T TT IS L+ PE + I + Sbjct: 219 RA-----QQEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILENPK 273 Query: 349 TVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVF 408 + A + E R+S + +DT + G I + V Sbjct: 274 ------------------LIPAAVDEVLRYSGSI-VGWRRKALKDTEIGGVAIKEGDGVL 314 Query: 409 VNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEI 468 + N D +E+ EF R + + + FG G C+G +LAK + Sbjct: 315 LLMGSANRDEARFENGEEFDISR-----------ANAREHLSFGFGIHYCLGNMLAKLQA 363 Query: 469 FLFLAILLQ-----------------QLEFSVPPGVKV 489 + L + + L F VP V V Sbjct: 364 KICLEEVTRLVPSLHLVADKAIGFRENLSFRVPTSVPV 401 >1ODO-A nrPDB Length = 408 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 69/420 (16%), Positives = 123/420 (29%), Gaps = 77/420 (18%) Query: 88 LSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLT-------FSTDSGPVWAARRRLA 140 +S ++Q L R + L T GP RRL Sbjct: 43 VSDPVLLKQLLTSSDVSKDARAHWPAFGEVVGTWPLALWVAVENMFTAYGPNHRKLRRLV 102 Query: 141 QNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVI 200 A + + + + V L+ RL EL AG D ++ + + Sbjct: 103 APAFSARRVDA---------MRPAVEAMVTGLVDRLAELPAGE-PVDLRQELAYPLPIAV 152 Query: 201 GAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRF 260 G +LV + +A R Sbjct: 153 IGHLMGVPQDRRDG-FRALVDGVFDT--------------------TLDQAEAQANTARL 191 Query: 261 LWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFD 320 L + + D+T L G+ + E++ + + + AG++ Sbjct: 192 YEVLDQLI----AAKRATPGDDMTSLLIAARDDE--GDGDRLSPEELRDTLLLMISAGYE 245 Query: 321 TVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSS 380 T I ++ L+T+P+ ++K +D + ET RH Sbjct: 246 TTVNVIDQAVHTLLTRPDQLALVRK---------GEVTWAD---------VVEETLRHEP 287 Query: 381 FLPFTIPHSTTRDTTL-NGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTA 439 + D L +G I + + + N P+ ED F R + Sbjct: 288 AVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADTFDATRTVKE---- 343 Query: 440 INKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL-EFSVPPGVKVDLTPIYGLT 498 + FG G C+G LA+ E+ L L L + + + + +L P+ L Sbjct: 344 --------HLAFGHGVHFCLGAPLARMEVTLALESLFGRFPDLRLADPAE-ELPPVPSLI 394 >1Z8P-A nrPDB Length = 404 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 65/469 (13%), Positives = 142/469 (30%), Gaps = 90/469 (19%) Query: 56 TLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVR-------QGDDFKGR 108 + + + + + + V +R +++ D + AL + Sbjct: 11 SFHVDWYRTYAELRET-APVTPVRFLGQDAWLVTGYDEAKAALSDLRLSSDPKKKYPGVE 69 Query: 109 PDLYTSTLITDGQSLTFSTDSG----PVWAARRRLAQNALNTFSIASDPASSSSCYLEEH 164 + + F+T+ G P R+L + E Sbjct: 70 VEFPAYLGFPEDVRNYFATNMGTSDPPTHTRLRKLVSQEFTVRRV-------------EA 116 Query: 165 VSKEAKALISRLQELMAGPGHFDPYNQVVV-SVANVIGAMCFGQHFPESSDEMLSLVKNT 223 + + + + L + + G D ++ VI + Sbjct: 117 MRPRVEQITAELLDEVGDSGVVDIVDRFAHPLPIKVICELL------------------- 157 Query: 224 HEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDI 283 V+ G + + + ++ + + F+ V+ + D+ Sbjct: 158 --GVDEKYRGEFGRWSSEILVMDPERAEQRGQAAREVVNFILDLVERRRTE----PGDDL 211 Query: 284 TGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKI 343 AL + + +++ ++ + AGF++ + I L+T P+ + Sbjct: 212 LSALIRVQDD----DDGRLSADELTSIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALV 267 Query: 344 QKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPK 403 +++ L + E R+ + P T + + G IP+ Sbjct: 268 RRDPSA------------------LPNAVEEILRYIAP-PETTTRFAAEEVEIGGVAIPQ 308 Query: 404 KCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVL 463 V V N DP+ + DP F R + + FG G C+G L Sbjct: 309 YSTVLVANGAANRDPKQFPDPHRFDVTRD------------TRGHLSFGQGIHFCMGRPL 356 Query: 464 AKWEIFLFLAILLQQLEFSVPPGVKV-DLTPIYGLTMKHARCEHVQARL 511 AK E + L L + ++ G+ D+ L ++ +H+ RL Sbjct: 357 AKLEGEVALRALFGRFP-ALSLGIDADDVVWRRSLLLRG--IDHLPVRL 402 >1GWI-A nrPDB Length = 411 Score = 146 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 52/300 (17%), Positives = 97/300 (32%), Gaps = 54/300 (18%) Query: 205 FGQHFPESSDEMLSLVKNTHEFVETASS---GNPLDFFPILRYLPNPALQRFKAFNQRFL 261 E +D +L + V+ ++ P+ L + L R K ++F Sbjct: 119 MRGRITELTDRLLDELPADGGVVDLKAAFAYPLPMYVVADLMGIEEARLPRLKVLFEKFF 178 Query: 262 WF-------------LQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIV 308 L + + D+T AL + S+ +G+ + +IV Sbjct: 179 STQTPPEEVVATLTELASIMTDTVAAKRAAPGDDLTSALIQASE-----NGDHLTDAEIV 233 Query: 309 NLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYL 368 + + + AG +T + I +++ L T PE + + LS + Sbjct: 234 STLQLMVAAGHETTISLIVNAVVNLSTHPEQRALV---------------LSGEAE---W 275 Query: 369 EAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELW-EDPSEF 427 A + ET R S+ + D + IP + V+ + D F Sbjct: 276 SAVVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADRF 335 Query: 428 RPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL---EFSVP 484 R + + FG G C G L++ E + L L + + +VP Sbjct: 336 DLTR-----------TSGNRHISFGHGPHVCPGAALSRMEAGVALPALYARFPHLDLAVP 384 >3ABB-A nrPDB Length = 408 Score = 145 bits (366), Expect = 4e-35, Method: Composition-based stats. Identities = 71/420 (16%), Positives = 136/420 (32%), Gaps = 84/420 (20%) Query: 74 DVLQIRIG-STPVLVLSRLDTIRQALVR-QGDDFKGRPDLYTSTLITDGQSLTFSTDSG- 130 + Q+ + P +++ R LV + G PD T+ + G Sbjct: 38 PLTQVTLFDGRPAWLITGHAEGRALLVDPRLSSDWGHPDFPVVVRRTEDRGGLAFPLIGV 97 Query: 131 --PVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRL-QELMAGPGHFD 187 PV A +RR+ + + + + ++L+ RL +++A D Sbjct: 98 DDPVHARQRRMLIPSFGVKRMNA-------------IRPRLQSLVDRLLDDMLAKGPGAD 144 Query: 188 PYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPN 247 + + V +V A+C P + + + FV A+S F Sbjct: 145 LVSAFALPVPSV--AICELLGVPYGDHDFFE--ECSRNFVGAATSAEADAAF-------- 192 Query: 248 PALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKI 307 +L V + + L + + +++ Sbjct: 193 ----------GELYTYLHGLVGRKQAE----PEDGLLDELIARQLEEGD-----LDHDEV 233 Query: 308 VNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPY 367 V + + AG +T AI+ + L+ PE + ++ V G Sbjct: 234 VMIALVLLVAGHETTVNAIALGALTLIQHPEQIDVLLRDPGAVSG--------------- 278 Query: 368 LEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEF 427 + E R +S + D + G I V V+ +N D + +E+P F Sbjct: 279 ---VVEELLRFTSVSDHIV-RMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIF 334 Query: 428 RPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQ---LEFSVP 484 R + + FG G +C+G+ LA+ E+ + L L + L +VP Sbjct: 335 DARR------------NARHHVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLAVP 382 >6B11-A nrPDB Length = 440 Score = 145 bits (366), Expect = 4e-35, Method: Composition-based stats. Identities = 38/237 (16%), Positives = 78/237 (32%), Gaps = 42/237 (17%) Query: 254 KAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNL-----------I 302 + + Q + +RD L G L + Sbjct: 205 RDYFQERTEQATRPAAGEEALEALLELRDYLDRLISGKTGRESGDGMLGSMVAQARGGGL 264 Query: 303 PQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDR 362 +++ + AG +T + ++ S++ L+ P R++ + G Sbjct: 265 SHADVLDNAVLLLAAGHETTASMVTMSVLVLLQHPTAWRELTVNPGLLPG---------- 314 Query: 363 PQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWE 422 + E R+ S + S T D ++G I + N D ++ Sbjct: 315 --------AVDELLRYLSIAD-GLRRSATADIEIDGHTIRAGDGLVFLLAAANRDEAVFS 365 Query: 423 DPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 +P F R + + + FG G +C+G+ LA+ E+ + L +L++L Sbjct: 366 EPEAFDIHR------------SARRHVAFGYGPHQCLGQNLARMELEVALGAVLERL 410 >3RWL-A nrPDB Length = 426 Score = 145 bits (365), Expect = 5e-35, Method: Composition-based stats. Identities = 43/276 (15%), Positives = 90/276 (32%), Gaps = 55/276 (19%) Query: 224 HEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF----LQKTVQEHYQDF---- 275 ++V+ S L P ++ ++ + ++ + + Sbjct: 159 FDWVDRVSIEITTQMLATLFDFPFEERRKLTRWSDVTTAAPGGGVVESWDQRKTELLECA 218 Query: 276 -----------DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTT 324 +K+ D+ L + + E+ + V + G DT Sbjct: 219 AYFQVLWNERVNKDPGNDLISML------AHSPATRNMTPEEYLGNVLLLIVGGNDTTRN 272 Query: 325 AISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPF 384 +++ ++ L P+ K++ V E + E R + L Sbjct: 273 SMTGGVLALHKNPDQFAKLKANPALV------------------ETMVPEIIRWQTPLAH 314 Query: 385 TIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPL 444 + + D+ L G I K V + + N D E+ + P EF +R P Sbjct: 315 -MRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDR-----------PR 362 Query: 445 SEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480 + + FG G RC+G LA+ ++ + +L + Sbjct: 363 PRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFS 398 >4XE3-A nrPDB Length = 407 Score = 144 bits (364), Expect = 6e-35, Method: Composition-based stats. Identities = 72/477 (15%), Positives = 134/477 (28%), Gaps = 111/477 (23%) Query: 42 PPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRI--GSTPVLVLSRLDTIRQALV 99 P P+ P L +PH A R + V ++R+ G +++R+ R L Sbjct: 15 PAYPFSLP-----HALDLDPHYAELRRDE---PVSRVRLPYGEGTAWLVTRMSDARIVLG 66 Query: 100 R-QGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 + T + P RRL A + Sbjct: 67 DSRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHTRLRRLVGKAFTARRV--------- 117 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218 E + ++L+ L + M G Sbjct: 118 ----EEMRPRVRSLVDSLLDDMVAHGS--------------------------------- 140 Query: 219 LVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFN--------------QRFLWFL 264 + VE + P+ L +P F+ F+ QR Sbjct: 141 ----PADLVEFLAVPFPVAVICELLGVPLEDRDLFRTFSDAMLSSTRLTAAEIQRVQQDF 196 Query: 265 QKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTT 324 + D+ GAL + + + + + +IVN+ + AG +T Sbjct: 197 MVYMDGLVAQRRDAPTEDLLGALALATD-----NDDHLTKGEIVNMGVSLLIAGHETSVN 251 Query: 325 AISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPF 384 I+ + L+T+ + + + V A + E R++ + Sbjct: 252 QITNLVHLLLTERKRYESLVADPALV------------------PAAVEEMLRYTPLVSA 293 Query: 385 TIP-HSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKP 443 T D L+ + V+ N D E+++ E R Sbjct: 294 GSFVRVATEDVELSTVTVRAGEPCVVHFASANRDEEVFDHADELDFHR------------ 341 Query: 444 LSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMK 500 + FG G CIG L + E+ L+ L+++ L G+ ++ Sbjct: 342 ERNPHIAFGHGAHHCIGAQLGRLELQEALSALVRRFPTLDLAEPVAGLKWKQGMLIR 398 >5EX6-C nrPDB Length = 434 Score = 144 bits (364), Expect = 7e-35, Method: Composition-based stats. Identities = 69/430 (16%), Positives = 128/430 (29%), Gaps = 93/430 (21%) Query: 73 GDVLQIRIGS----TPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTD 128 G++ ++R+GS + + D +RQ L F R + I G F Sbjct: 62 GELTRVRLGSGADAEHTWLATGHDVVRQVLGDHTR-FSTRRRFDRNDEI--GGKGVFRPR 118 Query: 129 S---------GPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQEL 179 P RRL + Y+E+ V++ + E Sbjct: 119 ELVGNLMDYDPPEHTRLRRLLAPGFTH-----RKIRRMAPYIEQIVTERLDEM-----ER 168 Query: 180 MAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFF 239 P V+ + D+ ++ H ++ + SG Sbjct: 169 EGSPADLIELFA-DEVPGPVLCELLGVPR-----DDRAMFLQLCHRHLDASLSG------ 216 Query: 240 PILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASG 299 +R A + F +L V +D + G + G Sbjct: 217 -----------RRRAAAGEAFSRYLVTMVARERKD----PGDGLIGMVVA-------EHG 254 Query: 300 NLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRL 359 + + E++ + + AG D ++ I ++ L+ PE ++ Sbjct: 255 DTVTDEELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAALR--------------- 299 Query: 360 SDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPE 419 +P E + E R+ + P + D+T+ I V + N DP Sbjct: 300 ---GDVPAAERAVDELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPA 356 Query: 420 LWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 L D R + + FG G C+G LA+ E+ + L ++ Sbjct: 357 LLPDADRLDVTR------------EAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRF 404 Query: 480 ---EFSVPPG 486 + P G Sbjct: 405 PDLRLADPDG 414 >5NWS-A nrPDB Length = 435 Score = 144 bits (363), Expect = 9e-35, Method: Composition-based stats. Identities = 75/452 (16%), Positives = 131/452 (28%), Gaps = 90/452 (19%) Query: 57 LGKNPHLALSRMSQRYGDVLQIRIG-STPVLVLSRLDTIRQALVRQGDDFKGRPDLYTST 115 L +P R+ +R G V++ R TPV ++R D +R L + F P Sbjct: 32 LLADPFTGYGRLRER-GPVVRGRFVDGTPVWFVTRYDDVRAVL--RDPRFVNTPSPVPGE 88 Query: 116 LITDGQSLTFSTDSGPV-----------------WAARRRLAQNALNTFSIASDPASSSS 158 D + + P RRL A I Sbjct: 89 GGADPREGMMDLLNVPEPLRVYLLGSILDSDPPDHPRLRRLVTRAFAARRI--------- 139 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVV-SVANVIGAMCFGQHFPESSDEML 217 L + + A L++ L G D VI + Sbjct: 140 LGLRPGIERIADRLLAELPRREEEDGTVDLLEHFAYPLSITVICELVGIPATD------- 192 Query: 218 SLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDK 277 ++ E+ G+ + P +R + + + + +++ Sbjct: 193 --LERWREW-----GGDLVSMRP----------ERLRHSFPVMIDYCHRLIEQRRAA--- 232 Query: 278 NSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKP 337 +T L + G + + V ++ + AG +T I L+T P Sbjct: 233 -----LTDDLLSELIRAQDDDGGRLSDIETVTMILTLVLAGHETSAHLIGNGTAALLTHP 287 Query: 338 EIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLN 397 ++K+ L + E R + T D L Sbjct: 288 GQWALLRKDP------------------ALLPRAVHELMRWCGSVHVARLRYATEDLELA 329 Query: 398 GFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRR 457 G + + V + N DP + DP R +E + FG G Sbjct: 330 GTPVARGDAVQLVLVSANFDPRHYSDPDRLDITRHQE--------GQAENHVGFGHGIHY 381 Query: 458 CIGEVLAKWEIFLFLAILLQQL-EFSVPPGVK 488 C+G LA+ E + LA LL+ + ++ G Sbjct: 382 CLGATLARQEGEVALARLLETYPDLALADGDP 413 >1F4U-A nrPDB Length = 368 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 63/355 (17%), Positives = 122/355 (34%), Gaps = 37/355 (10%) Query: 130 GPVWAA-RRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALI-SRLQELMAGPGHFD 187 G +W R + LN FS S + LE+ + + + I +R L + P D Sbjct: 18 GNIWQVFSYRYTKEVLNNFSKFSSDLTGYHERLEDLRNGKIRFDIPTRYTMLTSDPPLHD 77 Query: 188 PYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHE-FVETASSGNPLDFFPILRYLP 246 + + + E++ +L + + V+ + P+ + LP Sbjct: 78 ELRSMSADIFSPQKLQTLETFIRETTRSLLDSIDPREDDIVKKLAVPLPIIVISKILGLP 137 Query: 247 NPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDIT-GALFKHSKKGPRASGNLIPQE 305 ++FK ++ + L K + + L ++ R + + Sbjct: 138 IEDKEKFKEWSDLVAFRLGKPGEIFELGKKYLELIGYVKDHLNSGTEVVSRVVNSNLSDI 197 Query: 306 KIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQL 365 + + + + AG +T T IS S++ + ++I++E Sbjct: 198 EKLGYIILLLIAGNETTTNLISNSVIDFTRF-NLWQRIREENL----------------- 239 Query: 366 PYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPS 425 YL+A I E R+S + T L I + V V N D E++ D Sbjct: 240 -YLKA-IEEALRYSPPV-MRTVRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVFHDGE 296 Query: 426 EFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480 +F P+R + FG G C+G LA+ E + + ++ Sbjct: 297 KFIPDR------------NPNPHLSFGSGIHLCLGAPLARLEARIAIEEFSKRFR 339 >3MGX-A nrPDB Length = 415 Score = 143 bits (361), Expect = 2e-34, Method: Composition-based stats. Identities = 41/227 (18%), Positives = 81/227 (35%), Gaps = 44/227 (19%) Query: 254 KAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVND 313 + + L + + + K D+ L + + + + ++ ++ Sbjct: 204 RQAHTEILVYFDELITARR----KEPGDDLVSTLV---------TDDDLTIDDVLLNCDN 250 Query: 314 IFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFIL 373 + G +T AI+ ++ L T P + ++ V + + Sbjct: 251 VLIGGNETTRHAITGAVHALATVPGLLTALRDGSADV------------------DTVVE 292 Query: 374 ETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL 433 E R +S + TT D T+NG +P V N DP ++DP F P R Sbjct: 293 EVLRWTSPA-MHVLRVTTADVTINGRDLPSGTPVVAWLPAANRDPAEFDDPDTFLPGR-- 349 Query: 434 TADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480 + + FG G C+G LA+ E+ + L +L +++ Sbjct: 350 ----------KPNRHITFGHGMHHCLGSALARIELSVVLRVLAERVS 386 >5FOI-A nrPDB Length = 408 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 67/413 (16%), Positives = 126/413 (30%), Gaps = 81/413 (19%) Query: 82 STPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSL-TFSTDSGPVWAARRRLA 140 +P ++SR + +R LV S DG + P RR+ Sbjct: 55 GSPTWLVSRYEHVRALLVDPRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHTRLRRMF 114 Query: 141 QNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVI 200 +A + + + K ++ RL L P + + VI Sbjct: 115 ISAFS---------VRQVETMRPEIEKIVDGILDRLLAL--EPPVDILTHLALPMSTQVI 163 Query: 201 GAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRF 260 + P E E E AS N P L Sbjct: 164 CHLL---GVPYEDREF------FQERSELASRPNDDRSMPALI---------------EL 199 Query: 261 LWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFD 320 + +L V+ D + R I +++VN + AG + Sbjct: 200 VEYLDGLVRTKTAHPDTG---------LLGTAVTERLLKGEITHQELVNNAVLLLAAGHE 250 Query: 321 TVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSS 380 T ++ S++ L+ PE +++++ + + + E R+ S Sbjct: 251 TSANQVTLSVLTLLRHPETAAELREQPE------------------LMPNAVDELLRYHS 292 Query: 381 FLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAI 440 + + T D L I + + NHD + + F R Sbjct: 293 IAD-GLRRAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHR--------- 342 Query: 441 NKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTP 493 + + FG G +C+G+ LA+ E+ + L L +++ P +++ P Sbjct: 343 ---PARHHVAFGYGPHQCLGQNLARLEMEVTLGKLFRRV-----PALRLAQEP 387 >2ZQJ-A nrPDB Length = 417 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 77/441 (17%), Positives = 153/441 (34%), Gaps = 65/441 (14%) Query: 51 LGHVLTLGKNPHLALSRMSQRY-GDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRP 109 L + LTL K +L + ++RY D+ Q R+ + ++ + + D F+ + Sbjct: 11 LDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGKNFICMTGAEAAK-VFYDT-DRFQRQN 68 Query: 110 DLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEA 169 L + G R++ +L T L E +++E Sbjct: 69 ALPKRVQKSLFGVNAIQGMDGSAH-IHRKMLFLSLMT--------PPHQKRLAELMTEEW 119 Query: 170 KALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVET 229 KA ++R ++ + + G E +D+ + +V Sbjct: 120 KAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVKERADDFIDMVDAFGAV--- 176 Query: 230 ASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFK 289 P + + R +++ +++ K + + Sbjct: 177 -----------------GPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMAF 219 Query: 290 HSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDT 349 H+++ + + +++N++ I ++ + +S + L P+ + ++ Sbjct: 220 HTQEDGSQLDSRMAAIELINVLRPIVA-----ISYFLVFSALALHEHPKYKEWLRS---- 270 Query: 350 VIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFV 409 G R E F+ E R+ F PF + +D N K V + Sbjct: 271 --GNSRER-----------EMFVQEVRRYYPFGPF-LGALVKKDFVWNNCEFKKGTSVLL 316 Query: 410 NQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK----RRCIGEVLAK 465 + + NHDP LW+ P EFRPERF + + M+ G G RC GE + Sbjct: 317 DLYGTNHDPRLWDHPDEFRPERFAEREENLFD------MIPQGGGHAEKGHRCPGEGITI 370 Query: 466 WEIFLFLAILLQQLEFSVPPG 486 + L L+ Q+E+ VP Sbjct: 371 EVMKASLDFLVHQIEYDVPEQ 391 >5LIE-A nrPDB Length = 414 Score = 141 bits (356), Expect = 6e-34, Method: Composition-based stats. Identities = 48/275 (17%), Positives = 86/275 (31%), Gaps = 52/275 (18%) Query: 224 HEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF-------------------L 264 +FV ++ P+ IL +P + F L Sbjct: 143 FDFVVEIAAELPMQMICILLGVPETDRHWLFEAVEPGFDFRGSRRATMPRLNVEDAGSRL 202 Query: 265 QKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTT 324 E D+ + + P A + ++ + +F AG +T Sbjct: 203 YTYALELIAGKRAEPADDMLSVVANATIDDPDAPA--LSDAELYLFFHLLFSAGAETTRN 260 Query: 325 AISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPF 384 +I+ L+ L P+ + ++ + + L I E R +S P Sbjct: 261 SIAGGLLALAENPDQLQTLRSDFE------------------LLPTAIEEIVRWTSPSPS 302 Query: 385 TIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPL 444 + +R +L G I V V + N DP +++ EF R Sbjct: 303 K-RRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITR------------K 349 Query: 445 SEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 + FG G C+G LA+ E+ + LL + Sbjct: 350 PNPHLGFGQGVHYCLGANLARLELRVLFEELLSRF 384 >6DCD-A nrPDB Length = 424 Score = 141 bits (355), Expect = 7e-34, Method: Composition-based stats. Identities = 56/287 (19%), Positives = 95/287 (33%), Gaps = 53/287 (18%) Query: 210 PESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQ----------- 258 DE L + EF+ + L +P + F+ Sbjct: 134 DRQLDEFLGAGEC--EFISEYAKPFATLVIADLLGVPEDDRKDFRVVLGADRMGRVGALD 191 Query: 259 ------RFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVN 312 L +L + +D + D+ AL + + +V Sbjct: 192 HESVGVNPLQWLDDKFSAYIEDRRRQPRNDVLTALATATYPDGSTPEVI----DVVRSAT 247 Query: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 372 +F AG +T ++ ++ L +P+IQR++++ + FI Sbjct: 248 FLFAAGQETTAKLLTAAMRVLGDRPDIQRRLRENR------------------SLIPNFI 289 Query: 373 LETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432 E+ R S + + TT+ G I V V N DP +EDP EFR +R Sbjct: 290 EESLRMDSPVKSD-SRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDR- 347 Query: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 P + M F G C G LA+ E + L +L ++ Sbjct: 348 ----------PNVREHMAFARGVHSCPGGPLARVEGRVSLERILDRM 384 >6F0B-A nrPDB Length = 395 Score = 141 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 64/420 (15%), Positives = 126/420 (30%), Gaps = 75/420 (17%) Query: 82 STPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQ 141 TP V S + +R L + R +T T RRL Sbjct: 37 GTPAHVFSGYEDVRTVLQDRRFSSDSRRPNFTELTPTLQSQAAAPPFVRTDNPDHRRL-- 94 Query: 142 NALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIG 201 +IA + L + + + ++ L E P + + V Sbjct: 95 ----RGTIAREFLPKHIELLRPAIREIVQGVLDGLAETAP------PQDMLEAFAVPVAS 144 Query: 202 AMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFL 261 A F + D L L + V S + Sbjct: 145 ATVFRLLGIPAEDRAL-LTRCVKGVVSAVGS---------------------EDEGAEVF 182 Query: 262 WFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDT 321 L + + QD + + L + + + + + ++ + G+DT Sbjct: 183 RTLGEYIGGLVQDPSELPEDSLIRRLVTGPYQEKQ-----LTFHETIGVILMLIVGGYDT 237 Query: 322 VTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSF 381 + IS SL+ +PE + + + + + E R+ + Sbjct: 238 TASTISLSLVSYALQPEKFSVVHEHPERI------------------PLLVEELLRYHTV 279 Query: 382 LPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAIN 441 + T D + G + V N D ++ +P E +R Sbjct: 280 SQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR---------- 329 Query: 442 KPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKH 501 S + FG G +C+G+ LA+ E+ + ++++L PG+++ + L +H Sbjct: 330 --PSVPHVGFGYGPHQCVGQALARVELQEAIPAVIRRL-----PGMRLACA-LEDLPFRH 381 >5Z9I-A nrPDB Length = 398 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 51/285 (17%), Positives = 91/285 (31%), Gaps = 62/285 (21%) Query: 221 KNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLW------------------ 262 K+ + V ++ PL L +P F+ + + L Sbjct: 120 KSQFDLVAEFAAPLPLIMISDLLGVPESDRALFRQWMDKMLDGSEKFESPETVLEQEEEL 179 Query: 263 --------FLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDI 314 ++ E + K D+ L G + +I N+ N + Sbjct: 180 HKELELLWEMRDYWHERAAESRKRPREDLISQLVHA-----EVDGQKLNDSQISNIANRL 234 Query: 315 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILE 374 G T I+ +++ L + +++ DR +P A + E Sbjct: 235 LVNGHLTTAMLIANTMLCLDAFSDQDARVRA---------------DRSLVP---ALLEE 276 Query: 375 TFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434 + R+ S + + +T + + G IPK + V N D +E P F R Sbjct: 277 SMRYMSPI-CGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGR--- 332 Query: 435 ADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 + FG G C+G LA+ E + ILL +L Sbjct: 333 ---------SPNAHLGFGRGIHFCLGRQLARMESKAAVEILLDRL 368 >5YHJ-A nrPDB Length = 413 Score = 139 bits (350), Expect = 3e-33, Method: Composition-based stats. Identities = 60/440 (13%), Positives = 140/440 (31%), Gaps = 67/440 (15%) Query: 51 LGHVLTLGKNPHLALSRMSQRY-GDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRP 109 L H + + +L ++ + + ++ + R+ V+ L + + + Sbjct: 11 LDHSVDFLREGYLFVANRRKSFQSNIFESRLLGERVICLGGEEAA-EVFYDANKFTRQDA 69 Query: 110 DLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEA 169 G+ + D R+ +L T +E++ + Sbjct: 70 APKRLLKTLFGEGGVQTLDGSE--HTHRKQMFMSLMT---------------KENIDRLL 112 Query: 170 KALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVET 229 + ++ Y+ + + E + ++ E + Sbjct: 113 RLTYREWNQIERMGEEIVLYDIAQEVLMKAVCEWSGVPLAKEEVGKRTEEMRLLFESGTS 172 Query: 230 ASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFK 289 P + + ++++ V+E + + Sbjct: 173 L----------------GPTYLQGRKARSSAEVWIRQMVKEVRSNRLLPNEHTALYEFSW 216 Query: 290 HSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAI--SWSLMYLVTKPEIQRKIQKEL 347 H + SG L+P+E + V +I TV ++ ++++ L P+++ ++ Sbjct: 217 HRDE----SGELLPEEVVAVEVLNILRP---TVAISVYVLFTVLALHQFPDVKEQV---- 265 Query: 348 DTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCV 407 +R ++ E F+ E R F P D +G+ P+ Sbjct: 266 -------------ERGEVSKTE-FVQEVRRFYPFFPVAAAR-VKTDFEWDGYAFPEGTLT 310 Query: 408 FVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK-PLSEKMMLFGMGKRRCIGEVLAKW 466 ++ + NHD +W +P F P RF + N P + FG RC GE + Sbjct: 311 LLDLYGTNHDVSIWTEPDRFDPSRFKDWKESPFNFIPQGGGDVDFG---HRCAGEHVTIA 367 Query: 467 EIFLFLAILLQQLEFSVPPG 486 + + + ++ ++VPP Sbjct: 368 ILAQVIELFTKEYAYTVPPQ 387 >5DQN-A nrPDB Length = 426 Score = 138 bits (348), Expect = 4e-33, Method: Composition-based stats. Identities = 58/353 (16%), Positives = 102/353 (28%), Gaps = 56/353 (15%) Query: 145 NTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVS-VANVIGAM 203 + + + +++EA L + M P H + IG + Sbjct: 67 RRSDVFGSSPDGAIPVYPQDMTREAVDLQRAVLLNMDAPQHTRLRKIISRGFTPRAIGRL 126 Query: 204 CFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLW- 262 + + +FVE S PL L +P + ++ Sbjct: 127 EDELRSRAQKIAQTAAAQGAGDFVEQVSCELPLQAIAELLGVPQDDRDKLFRWSNEMTAG 186 Query: 263 ---------------FLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKI 307 L + ++ N DI L + G + ++ Sbjct: 187 EDPEYADVDPAMSSFELISYAMKMAEERAVNPTEDIVTKLIEA-----DIDGEKLSDDEF 241 Query: 308 VNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPY 367 V + AG +T +I+ ++ P+ +KE R +D Sbjct: 242 GFFVVMLAVAGNETTRNSITHGMIAFAQNPDQWELYKKE--------RPETAAD------ 287 Query: 368 LEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEF 427 E R ++ + + D L G I K V ++ N D E++EDP F Sbjct: 288 ------EIVRWATPVS-AFQRTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTF 340 Query: 428 RPERFLTADGTAINKPLSEKMMLFGM-GKRRCIGEVLAKWEIFLFLAILLQQL 479 R + FG G CIG LA+ I L + + Sbjct: 341 NILR------------SPNPHVGFGGTGAHYCIGANLARMTINLIFNAIADNM 381 >2RFC-A nrPDB Length = 343 Score = 138 bits (348), Expect = 5e-33, Method: Composition-based stats. Identities = 46/284 (16%), Positives = 97/284 (34%), Gaps = 51/284 (17%) Query: 207 QHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQK 266 + F E + L + + + + P++ + +P+ + FK ++ + Sbjct: 75 KDFIEETSNDLIKNIDNKDIISEYAVRLPVNIISKILGIPDSDMPLFKLWSDYIIG---- 130 Query: 267 TVQEHYQDFDKNSVRDITGALFK----------HSKKGPRASGNLIPQEKIVNLVNDIFG 316 + ++F+ + R + L + + G + ++ + + + Sbjct: 131 --NKRDENFNYVNNR-MVSRLLEIFKSDSHGIINVLAGSSLKNRKLTMDEKIKYIMLLII 187 Query: 317 AGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETF 376 G +T T I + + P+I +D + F+ ET Sbjct: 188 GGNETTTNLIGNMIRVIDENPDI-------IDDALKNRS--------------GFVEETL 226 Query: 377 RHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTAD 436 R+ S + F D+ +N I K V V N D +++P F+ R Sbjct: 227 RYYSPIQFLPHRFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFDEPDLFKIGR----- 281 Query: 437 GTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480 E + FG+G C+G LA+ E + L +L + Sbjct: 282 --------REMHLAFGIGIHMCLGAPLARLEASIALNDILNHFK 317 >3OFT-A nrPDB Length = 396 Score = 138 bits (347), Expect = 6e-33, Method: Composition-based stats. Identities = 73/396 (18%), Positives = 130/396 (32%), Gaps = 54/396 (13%) Query: 111 LYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAK 170 + DG L +ST +G W A R + + ++ SS + + K + Sbjct: 27 FAAWKTLLDGPGLVWSTANGGHWIAAR---GDVVRELWGDAERLSSQCLAVTPGLGKVMQ 83 Query: 171 ALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETA 230 + LQ+ A F ++ V+ Q E L + + +FV Sbjct: 84 FI--PLQQDGAEHKAFRTPVMKGLASRFVVALEPKVQAVARKLMESLR-PRGSCDFVSDF 140 Query: 231 SSGNPLDFFPILRYLPNPALQRFKAFN------------QRFLWFLQKTVQEHYQDFDKN 278 + PL+ F L +P R + ++ + + Sbjct: 141 AEILPLNIFLTLIDVPLEDRPRLRQLGVQLTRPDGSMTVEQLKQAADDYLWPFIEKRMAQ 200 Query: 279 SVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPE 338 D+ + G ++ + ++ G DTV I ++L PE Sbjct: 201 PGDDLFSRILS-----EPVGGRPWTVDEARRMCRNLLFGGLDTVAAMIGMVALHLARHPE 255 Query: 339 IQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNG 398 QR +++ D + A E R + + + D +G Sbjct: 256 DQRLLRERPD------------------LIPAAADELMRRYPTV--AVSRNAVADVDADG 295 Query: 399 FYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRC 458 I K V++ N DP +E P E R +R L + G+G RC Sbjct: 296 VTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGLAPI----------RHTTMGVGAHRC 345 Query: 459 IGEVLAKWEIFLFLAILLQQL-EFSVPPGVKVDLTP 493 +G LA+ E+ +FL L + EF++ P V + Sbjct: 346 VGAGLARMEVIVFLREWLGGMPEFALAPDKAVTMKG 381 >1UED-A nrPDB Length = 406 Score = 137 bits (345), Expect = 1e-32, Method: Composition-based stats. Identities = 68/452 (15%), Positives = 134/452 (29%), Gaps = 91/452 (20%) Query: 60 NPHLALSRMSQRYGDVLQI------RIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYT 113 +PH + +G +++I ++G V + +R+ L + F RP Sbjct: 25 DPHEDNFGLRA-HGPLVRIVGESSTQLGRDFVWQAHGYEVVRRILGDH-EHFTTRPQFTQ 82 Query: 114 STLITDGQSLTFSTDSG---PVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAK 170 S ++ S P R++ I + S + EA+ Sbjct: 83 SKSGAHVEAQFVGQISTYDPPEHTRLRKMLTPEFTVRRIRRMEPAIQSLIDDRLDLLEAE 142 Query: 171 ALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETA 230 + LQ L A P +++ + E + ++ Sbjct: 143 GPSADLQGLFADPVGAHALCELLGIP-------------RDDQREFVRRIRR-------- 181 Query: 231 SSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKH 290 N L R + + + + G + Sbjct: 182 ----------------NADLSRGLKARAADSAAFNRYLDNLLARQRADPDDGLLGMIV-- 223 Query: 291 SKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTV 350 R G+ + E++ L + G +TV I + ++ L+ P + + + Sbjct: 224 -----RDHGDNVTDEELKGLCTALILGGVETVAGMIGFGVLALLDNPGQIELLFESPEK- 277 Query: 351 IGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVN 410 E + E R+ S + P +D ++G I V + Sbjct: 278 -----------------AERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCS 320 Query: 411 QWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFL 470 N D L DP R +D + FG G C+G LA+ + + Sbjct: 321 ILMANRDEALTPDPDVLDANRAAVSD------------VGFGHGIHYCVGAALARSMLRM 368 Query: 471 FLAILLQQLEFSVPPGVKVDLTPIYGLTMKHA 502 L ++ PG+++ + PI + + A Sbjct: 369 AYQTLWRRF-----PGLRLAV-PIEEVKYRSA 394 >6G5O-A nrPDB Length = 399 Score = 137 bits (345), Expect = 1e-32, Method: Composition-based stats. Identities = 42/226 (18%), Positives = 79/226 (34%), Gaps = 36/226 (15%) Query: 254 KAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVND 313 +A + L + E +N D+ L G + +E++ ++ Sbjct: 162 EALDGDKANILYHYIDEQIDRASENPGDDMYSVLL-----NSEFEGRKLTKEEVKGVMVL 216 Query: 314 IFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFIL 373 F G DTV A++ S+ YL PE +++KE + + Sbjct: 217 TFAGGRDTVINAVTNSIAYLAEHPEALERLRKEPE------------------ITGRAVE 258 Query: 374 ETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL 433 E R+ S L + T DT + + + + N D ++E+P+E +R Sbjct: 259 EMIRYFSPLT-QMGRVVTEDTHVCEHAVKADSRISLCWASANRDAAVFENPNEIVLDR-- 315 Query: 434 TADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 + FG C+G A+ + + L L Q++ Sbjct: 316 ----------KVNPHVGFGFSHHNCLGATHARQILKILLQTLAQKV 351 >4TRI-A nrPDB Length = 407 Score = 137 bits (345), Expect = 1e-32, Method: Composition-based stats. Identities = 44/247 (17%), Positives = 83/247 (33%), Gaps = 41/247 (16%) Query: 248 PALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKI 307 A+Q+ + F + + + + D+ L G + ++I Sbjct: 173 AAIQKLMDTFAAYTEFTKDVITKRRAE----PTDDLFSVLV-----NSEVEGQRMSDDEI 223 Query: 308 VNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPY 367 V I G +T +S L+ + + ++D + G Sbjct: 224 VFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVDLLPG--------------- 268 Query: 368 LEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEF 427 I E R +S + + + T DT +G + + + N D ++ DP F Sbjct: 269 ---AIEEMLRWTSPVK-NMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNF 324 Query: 428 RPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL-EFSVPPG 486 R +R + FG G C+G LA+ E+ L +L++L + + Sbjct: 325 RIDR------------NPNSHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADD 372 Query: 487 VKVDLTP 493 V L P Sbjct: 373 APVPLRP 379 >6HQW-A nrPDB Length = 445 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 42/303 (13%), Positives = 98/303 (32%), Gaps = 41/303 (13%) Query: 186 FDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYL 245 + ++ A+V+ ++ +G+ F + L + + + Sbjct: 154 VEMEAEIRRRTASVLDSLPWGERFDWVDKVSIELTTGMLAILFGFPWADRRLLTFWSDWA 213 Query: 246 PNPALQRFKAFNQRFLWFLQKTVQEHY----QDFDKNSVRDITGALFKHSKKGPRASGNL 301 + L + FL + D+ + N Sbjct: 214 GDVELTLARELADTRFGFLGEMAHYFQRLWGARMQAPPSGDLISMMIHSEAM------NH 267 Query: 302 IPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSD 361 + ++ + + + G DT +S + L P+ + ++++ Sbjct: 268 MSPQEFMGNLVLLIVGGNDTTRNTMSGIVHALDKFPDQRELLERDA-------------- 313 Query: 362 RPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELW 421 + + E R+ + L + + T DT L G I V + N D ++ Sbjct: 314 ----SLIPNAVQECIRYVTPLAH-MRRTATADTELFGNQIKAGEKVILWYISANRDETVF 368 Query: 422 EDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILL-QQLE 480 E+P + +R P + + + FG G RC+G LA+ ++ + L + +++ Sbjct: 369 ENPDKLMVDR-----------PNARRHLSFGHGIHRCVGARLAELQLRILLEEMHERRMR 417 Query: 481 FSV 483 V Sbjct: 418 VRV 420 >2WM5-A nrPDB Length = 435 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 53/304 (17%), Positives = 92/304 (30%), Gaps = 56/304 (18%) Query: 220 VKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF---------------- 263 + V + PL + +P QR + L F Sbjct: 164 PDRQADLVSELAGPLPLQIICDMMGIPKADHQRIFHWTNVILGFGDPDLATDFDEFMQVS 223 Query: 264 --LQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDT 321 + +D N D+T +L + G + +I + + AG +T Sbjct: 224 ADIGAYATALAEDRRVNHHDDLTSSLVEA-----EVDGERLSSREIASFFILLVVAGNET 278 Query: 322 VTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSF 381 AI+ ++ L PE + + + D + + E R +S Sbjct: 279 TRNAITHGVLALSRYPEQRDRWWSDFDGL-----------------APTAVEEIVRWASP 321 Query: 382 LPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAIN 441 + + + T+D L G + V + N D + DP F R Sbjct: 322 V-VYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLAR---------- 370 Query: 442 KPLSEKMMLF-GMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDL--TPIYGLT 498 + F G G C+G LA+ EI + L +Q+ V L I+G+ Sbjct: 371 --NPNPHLGFGGGGAHFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIK 428 Query: 499 MKHA 502 Sbjct: 429 TLPV 432 >5M0P-A nrPDB Length = 428 Score = 136 bits (341), Expect = 3e-32, Method: Composition-based stats. Identities = 79/453 (17%), Positives = 149/453 (32%), Gaps = 65/453 (14%) Query: 51 LGHVLTLGKNPHLALSRMSQRYG-DVLQIR-IGSTPVLVLSRLDTIRQALVRQGDDFKGR 108 L + L + K +L + R V Q + +G P +V++ + + D + Sbjct: 16 LDNTLKVLKQGYLYTTNQRNRLNTSVFQTKALGGKPFVVVTGKEGAE--MFYNNDVVQRE 73 Query: 109 PDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKE 168 L + T T G R+ L + + ++ +V + Sbjct: 74 GMLPKRIVNTLAGKGAIHTVDGKKHVDRKALFMSLMTEGNL-------------NYVREL 120 Query: 169 AKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVE 228 + L + M + Y + +V + V Q PE + + + + + Sbjct: 121 TRTLWHANTQRMESMDEVNIYRESIVLLTKVGTRWAGVQAPPEDIERIATDMDIMIDSFR 180 Query: 229 TASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALF 288 + K +R +L++ + E + Sbjct: 181 ALGGAF-------------KGYKASKEARRRVEDWLEEQIIETRKGNIHPPEGTALYEFA 227 Query: 289 KHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELD 348 + ++N + + +S+ L + P + KI+ E D Sbjct: 228 HWEDYLGNPMDSRTCAIDLMNTFRPLIA-----INRFVSFGLHAMNENPITREKIKSEPD 282 Query: 349 TVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVF 408 Y F E R+ F+PF +P D G IP + Sbjct: 283 ------------------YAYKFAQEVRRYYPFVPF-LPGKAKVDIDFQGVTIPAGVGLA 323 Query: 409 VNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMG----KRRCIGEVLA 464 ++ + HD LW+DP+EFRPERF T DG+ + ++ G G RC GE + Sbjct: 324 LDVYGTTHDESLWDDPNEFRPERFETWDGSPFD------LIPQGGGDYWTNHRCAGEWIT 377 Query: 465 KWEIFLFLAILLQQLEFSVPP-GVKVDLTPIYG 496 + + +++ + VP ++VDL I G Sbjct: 378 VIIMEETMKYFAEKITYDVPEQDLEVDLNSIPG 410 >3TKT-A nrPDB Length = 450 Score = 134 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 69/398 (17%), Positives = 129/398 (32%), Gaps = 61/398 (15%) Query: 86 LVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQS---LTFSTDSGPVWAARRRLAQN 142 ++ + D + F R + IT G + P RRL Q+ Sbjct: 82 VMKASKDNATFLNNPKSTVFTLRVGEMMAKAITGGSPHLVESLVQMDAPKHPKLRRLTQD 141 Query: 143 ALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGA 202 ++A L+ + K A I R+ G F + V+ Sbjct: 142 WFMPKNLAR---------LDGEIRKIANEAIDRML-GAGEEGDFMALVAAPYPLHVVM-- 189 Query: 203 MCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLW 262 G PE +ML L + + + + L P P Q F Sbjct: 190 QILGVP-PEDEPKMLFLTQQMFGGQDEDMNKSGLKDLP-----PEQISQIVAGAVAEFER 243 Query: 263 FLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 322 + E +N D+ + G + AG DT Sbjct: 244 YFAGLAAERR----RNPTDDVATVIANAVV-----DGEPMSDRDTAGYYIITASAGHDTT 294 Query: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 382 + + + + + L P++ +++ + + + G + E R ++ + Sbjct: 295 SASSAGAALALARDPDLFARVKADRNLLPG------------------IVEEAIRWTTPV 336 Query: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442 + + DT L G I + +N NHDP + +P +F P R Sbjct: 337 QHFM-RTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTR----------- 384 Query: 443 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480 + + + FG G +C+G LA+ E+ + L +LL +++ Sbjct: 385 -PANRHLAFGAGSHQCLGLHLARLEMRVLLDVLLDRVD 421 >3A1L-A nrPDB Length = 425 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 56/358 (15%), Positives = 112/358 (31%), Gaps = 54/358 (15%) Query: 137 RRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV--V 194 RRL +NA D ++ EH + + ++ + P H + + + Sbjct: 63 RRLGRNARVASG---DTDTAPVPIPTEH--RALRTVVENWLVFLDPPHHTELRSLLTTEF 117 Query: 195 SVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFK 254 S + V G + + L + + VE ++ P+ L +P + Sbjct: 118 SPSIVTGLRPRIAELASALLDRLRAQRRP-DLVEGFAAPLPILVISALLGIPEEDHTWLR 176 Query: 255 AFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGP---------------RASG 299 A ++ + F+ R +G Sbjct: 177 ANAVALQEASTTRARDGRGYARAEAASQEFTRYFRREVDRRGGDDRDDLLTLLVRARDTG 236 Query: 300 NLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRL 359 + + + IV + AG +T T ++ +++ L ++ +++ ++ Sbjct: 237 SPLSVDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELRTTPES---------- 286 Query: 360 SDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPE 419 A + E R+ + + D L IP+ V N DP Sbjct: 287 --------TPAAVEELMRYDPPVQ-AVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDPA 337 Query: 420 LWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ 477 + DP R +E+ + FG+G C+G LA+ E + L LL Sbjct: 338 RFPDPDVLDVHR------------AAERQVGFGLGIHYCLGATLARAEAEIGLRALLD 383 >3AWQ-A nrPDB Length = 415 Score = 131 bits (330), Expect = 5e-31, Method: Composition-based stats. Identities = 76/454 (16%), Positives = 140/454 (30%), Gaps = 73/454 (16%) Query: 53 HVLTLGKNPHLALSRMSQRYG-DVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDL 111 L+L +P+ +SR QR G + + R L + F+ + Sbjct: 12 ETLSLLADPYRFISRQCQRLGANAFESRFLLKKTNCLKGAKAA-EIFYDTTR-FEREGAM 69 Query: 112 YTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKA 171 + T G R+++ + E V A+ Sbjct: 70 PVAIQKTLFGQGGVQGLDGETHRHRKQMFMGLMTP----------------ERVRALAQL 113 Query: 172 LISRLQEL---MAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVE 228 + + G Y+++ + + A P DE + + Sbjct: 114 FEAEWRRAVPGWTRKGEIVFYDELHEPLTRAVCAWA---GVPLPDDEAGNRAGELRALFD 170 Query: 229 TASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALF 288 A S +P + L A +R A+ +R ++ + I Sbjct: 171 AAGSASPRHLWSRL------ARRRVDAWAKRI---IEGIRAGSIGSGSGTAAYAIAWHRD 221 Query: 289 KHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELD 348 +H +L+ + ++ T AI+ + ++ Sbjct: 222 RH--------DDLLSPHVAAVELVNVLRP-----TVAIAVYITFVAH------------- 255 Query: 349 TVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVF 408 + R + Q Y E F+ E R F P + ++D G P+ V Sbjct: 256 -ALQTCSGIRAALVQQPDYAELFVQEVRRFYPFFPAVVAR-ASQDFEWEGMAFPEGRQVV 313 Query: 409 VNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK----RRCIGEVLA 464 ++ + NHD W DP EFRPERF D + N + G G RC GE + Sbjct: 314 LDLYGSNHDAATWADPQEFRPERFRAWDEDSFN------FIPQGGGDHYLGHRCPGEWIV 367 Query: 465 KWEIFLFLAILLQQLEFSVPP-GVKVDLTPIYGL 497 + + +L+ + + VP + +D + L Sbjct: 368 LAIMKVAAHLLVNAMRYDVPDQDLSIDFARLPAL 401 >2FR7-A nrPDB Length = 412 Score = 131 bits (330), Expect = 6e-31, Method: Composition-based stats. Identities = 40/183 (21%), Positives = 68/183 (37%), Gaps = 31/183 (16%) Query: 297 ASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERR 356 + I E+ LV + AG DT I+ ++ L P+ +++ + Sbjct: 231 SDTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRADP--------- 281 Query: 357 PRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNH 416 E R S + T +TTRD L G I + V + N Sbjct: 282 ---------SLARNAFEEAVRFESPVQ-TFFRTTTRDVELAGATIGEGEKVLMFLGSANR 331 Query: 417 DPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILL 476 DP W+DP + R + + FG G C+G+++A+ E + LA L Sbjct: 332 DPRRWDDPDRYDITR------------KTSGHVGFGSGVHMCVGQLVARLEGEVVLAALA 379 Query: 477 QQL 479 +++ Sbjct: 380 RKV 382 >5DE9-A nrPDB Length = 410 Score = 131 bits (330), Expect = 6e-31, Method: Composition-based stats. Identities = 68/361 (18%), Positives = 116/361 (32%), Gaps = 56/361 (15%) Query: 149 IASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFG-Q 207 + +DP ++ V++ A + G DP + + + G + Sbjct: 63 VTNDPRFGREAVMDRQVTRLAP----HFRPARGAVGFLDPPDHTRLRRSVAAAFTARGVE 118 Query: 208 HFPESSDEMLSLV-------KNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRF 260 E S ML + + E S P+ L +P + Q Sbjct: 119 RVRERSRGMLDELVDAMLRAGPPADLTEAVLSPFPIAVICELMGVPATDRHSMHTWTQLI 178 Query: 261 LWFLQKT-VQEHYQDFDKNSVRDITGALFKHSKK------GPRASGNLIPQEKIVNLVND 313 L V E ++ D+ G + + G + I + V L Sbjct: 179 LSSSHGAEVSERAKNEMNAYFSDLIGLRSDSAGEDVTSLLGAAVGRDEITLSEAVGLAVL 238 Query: 314 IFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFIL 373 + G + VT L+++PE+ +++ E E RPR D Sbjct: 239 LQIGG-EAVTNNSGQMFHLLLSRPELAERLRSE------PEIRPRAID------------ 279 Query: 374 ETFRHSSFL-PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432 E R + D + G I V+V+ N DPE++ DP ER Sbjct: 280 ELLRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFER- 338 Query: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLT 492 + FG G C G +LA+ E L + +L ++ PG+K+ + Sbjct: 339 -----------SPNPHVSFGFGPHYCPGGMLARLESELLVDAVLDRV-----PGLKLAVA 382 Query: 493 P 493 P Sbjct: 383 P 383 >6FSH-A nrPDB Length = 398 Score = 131 bits (329), Expect = 7e-31, Method: Composition-based stats. Identities = 53/394 (13%), Positives = 100/394 (25%), Gaps = 76/394 (19%) Query: 90 RLDTIRQALVRQGDDFKGRPDLYTSTLI----TDGQSLTFSTDSGPVWAARRRLAQNALN 145 +RQ L F R I RL L Sbjct: 47 GHAVVRQVLGDHQQ-FSTRRRWDPRDEIGGKGIFRPRELVGNLMDYDPPEHTRLRH--LL 103 Query: 146 TFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCF 205 T + +EE V+ A+ AGP V+ + Sbjct: 104 TPGFTQRRMRRLAPRIEEIVTDRLDAM------EQAGPPADLIELFADEVPGAVLCELI- 156 Query: 206 GQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQ 265 G + +K H ++ + S + Sbjct: 157 GVPRDDRD----MFMKLCHGHLDASLS---------------------QKRRAALGDKFS 191 Query: 266 KTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTA 325 + + K+ G++ G+ I E++ + + AG D V+ Sbjct: 192 RYLLAMIARERKDPGDGFIGSIVA-------EHGDTITDEELRGVCVQLMLAGDDNVSGM 244 Query: 326 ISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFT 385 I ++ L+ PE ++ + + + + E R+ + Sbjct: 245 IGLGVLALLRHPEQIAALRGDDQS------------------ADRAVDELIRYLTVPYAP 286 Query: 386 IPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLS 445 P + D + I + V + N D L D R Sbjct: 287 TPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR------------TP 334 Query: 446 EKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 + FG G C+G L + ++ + L ++ Sbjct: 335 VPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRF 368 >2XKR-A nrPDB Length = 398 Score = 131 bits (329), Expect = 7e-31, Method: Composition-based stats. Identities = 53/349 (15%), Positives = 105/349 (30%), Gaps = 68/349 (19%) Query: 131 PVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYN 190 P RR+L + AS ++ LI + E D Sbjct: 81 PAHLLRRKLVNAGFTRKRVKDKEAS---------IAALCDTLIDAVCERGECDFVRDLAA 131 Query: 191 QVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPAL 250 + ++V G ++ ++ + + V SS ++ Sbjct: 132 PLPMAVI--------GDMLGVRPEQRDMFLRWSDDLVTFLSS-----------HVSQEDF 172 Query: 251 QRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNL 310 Q + F + T+ D D+ L G + +++V Sbjct: 173 QITMDAFAAYNDFTRATIAARRAD----PTDDLVSVLVS-----SEVDGERLSDDELVME 223 Query: 311 VNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEA 370 I G +T +S L+ + +Q++ + G Sbjct: 224 TLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDPSLLPG------------------ 265 Query: 371 FILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPE 430 I E R ++ + + T DT +G + + + N D ++ +P +F + Sbjct: 266 AIEEMLRWTAPVK-NMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQ 324 Query: 431 RFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 R + FG G C+G LA+ E+ L +L++L Sbjct: 325 R------------NPNSHLAFGFGTHFCLGNQLARLELSLMTERVLRRL 361 >6CVC-A nrPDB Length = 433 Score = 131 bits (328), Expect = 1e-30, Method: Composition-based stats. Identities = 80/490 (16%), Positives = 143/490 (29%), Gaps = 87/490 (17%) Query: 30 GLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPH---LALSRMSQR-----YGDVLQIRI- 80 GL PRV G P P LG + G++ A + + + + + + Sbjct: 10 GLLPRV-NGTPPPEVPLADIELGSLEFWGRDDDFRDGAFATLRREAPISFWPPIELAGLT 68 Query: 81 GSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLI-----TDGQSLTFSTDSGPVWAA 135 L++ D I A R + F P++ G + P Sbjct: 69 AGKGHWALTKHDDIHFA-SRHPEIFHSSPNIVIHDQTPELAEYFGSMIVLDD---PRHQR 124 Query: 136 RRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVS 195 R + A +E V + A L++ + E Sbjct: 125 LRSIVSRAFTP---------KVVARIEASVRERAHRLVAAMIENHPDGQADLVSELAGPL 175 Query: 196 VANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKA 255 +I +M+ + + HE + ++ +P L Sbjct: 176 PLQIIC-------------DMMGIPEEDHE--------QIFHWTNVILGFGDPDLTTDFD 214 Query: 256 FNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIF 315 + + D N D+T +L + G + +I + Sbjct: 215 EFLQVSMAIGGYATALADDRRVNHHGDLTTSLVEA-----EVDGERLSSSEIAMFFILLV 269 Query: 316 GAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILET 375 AG +T AIS ++ L P+ + K + D + + E Sbjct: 270 VAGNETTRNAISHGMLALSRYPDERAKWWSDFDGLAAT-----------------AVEEI 312 Query: 376 FRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTA 435 R +S + + + ++D L G + V + N D E + DP F R Sbjct: 313 VRWASPV-VYMRRTLSQDVDLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTR---- 367 Query: 436 DGTAINKPLSEKMMLF-GMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDL--T 492 + F G G C+G LA+ EI + L +Q+ V L Sbjct: 368 --------NPNPQVGFGGGGAHFCLGANLARREIRVVFDELRRQMPDVVATEEPARLLSQ 419 Query: 493 PIYGLTMKHA 502 I+G+ Sbjct: 420 FIHGIKRLPV 429 >1Q5D-A nrPDB Length = 419 Score = 131 bits (328), Expect = 1e-30, Method: Composition-based stats. Identities = 54/299 (18%), Positives = 100/299 (33%), Gaps = 69/299 (23%) Query: 224 HEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRF----------------------- 260 + V + G P+ L +P ++F+ F Sbjct: 143 FDVVRDYAEGIPMRAISALLKVPAECDEKFRRFGSATARALGVGLVPRVDEETKTLVASV 202 Query: 261 ---LWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGA 317 L L + E ++ +N D+ L + A G+ + +++V LV I A Sbjct: 203 TEGLALLHGVLDERRRNPLEN---DVLTMLLQA-----EADGSRLSTKELVALVGAIIAA 254 Query: 318 GFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFR 377 G DT I+++++ L+ PE ++ E + + E R Sbjct: 255 GTDTTIYLIAFAVLNLLRSPEALELVKAEPG------------------LMRNALDEVLR 296 Query: 378 HSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADG 437 + L +D G I K VF+ D ++ P F R +A Sbjct: 297 FDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIPSALRDGTVFSRPDVFDVRRDTSAS- 355 Query: 438 TAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYG 496 + +G G C G LA+ E + + + ++ P +K+ TP++G Sbjct: 356 -----------LAYGRGPHVCPGVSLARLEAEIAVGTIFRRF-----PEMKLKETPVFG 398 >5FYF-A nrPDB Length = 470 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 68/468 (14%), Positives = 144/468 (30%), Gaps = 70/468 (14%) Query: 22 CLVFWVLKGLRPR--VPKGLKSP-PEPWGWPL----LGHVLTLGKNPHLALSRMSQRYGD 74 L+ K PR +P+ +++P P+ L + + + A + + Sbjct: 34 FLMSAKRKTFGPRRPMPEFVETPIPDVNTLALEDIDVSNPFLYRQGQWRAYFKRLRDEAP 93 Query: 75 V-LQIRIGSTPVLVLSRLDTIRQALVRQGDD-FKGRPDLYTSTLITDGQSLTFSTDSGPV 132 V Q P ++R + I V + D F P + F P Sbjct: 94 VHYQKNSPFGPFWSVTRFEDI--LFVDKSHDLFSAEPQIILGDPPEGLSVEMFIAMDPPK 151 Query: 133 WAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQV 192 +R Q + ++ +E + ++ L F+ V Sbjct: 152 HDVQRSSVQGVVAPKNLKE---------MEGLIRSRTGDVLDSLPTDK----PFNWVPAV 198 Query: 193 VVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQR 252 + + A FP L + +A+ G D + + A Sbjct: 199 SKELTGRMLATLL--DFPYEERHKLVEWSDRMAGAASATGGEFADENAMFDDAADMARSF 256 Query: 253 FKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVN 312 + + + + + D+ L + +K+ + + + + Sbjct: 257 SRLWRDK---------EARRAAGE-EPGFDLIS-LLQSNKETKDLINRPM---EFIGNLT 302 Query: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFI 372 + G DT ++S L+ + P K++ + + + Sbjct: 303 LLIVGGNDTTRNSMSGGLVAMNEFPREFEKLKA------------------KPELIPNMV 344 Query: 373 LETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432 E R + L + + +D L G I K V + N D +++P +F +R Sbjct: 345 SEIIRWQTPLAY-MRRIAKQDVELGGQTIKKGDRVVMWYASGNRDERKFDNPDQFIIDR- 402 Query: 433 LTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480 + M FG G RC+G LA+ ++ + +L++ + Sbjct: 403 ----------KDARNHMSFGYGVHRCMGNRLAELQLRILWEEILKRFD 440 >1LG9-A nrPDB Length = 398 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 39/226 (17%), Positives = 67/226 (29%), Gaps = 37/226 (16%) Query: 254 KAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVND 313 + + + K + GA+ G+ E++ Sbjct: 180 QKRRAALGDKFSRYLLAMIARERKEPGEGMIGAVVAEY-------GDDATDEELRGFCVQ 232 Query: 314 IFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFIL 373 + AG D ++ I ++ ++ PE +D G E+ + + Sbjct: 233 VMLAGDDNISGMIGLGVLAMLRHPEQ-------IDAFRGDEQS-----------AQRAVD 274 Query: 374 ETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL 433 E R+ + P D TL G I K V + N DP L D R Sbjct: 275 ELIRYLTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTR-- 332 Query: 434 TADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 + FG G C+G LA+ E+ L ++ Sbjct: 333 ----------EPIPHVAFGHGVHHCLGAALARLELRTVFTELWRRF 368 >2WIY-A nrPDB Length = 394 Score = 128 bits (322), Expect = 5e-30, Method: Composition-based stats. Identities = 49/332 (14%), Positives = 102/332 (30%), Gaps = 54/332 (16%) Query: 149 IASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQH 208 + + L + + + L+ L + + + + V +V A Sbjct: 90 LRRQTNKWFTPKLVDGWVRTTRELVGDLLDGVEAGQVIEARRDLAVVPTHVTMARVLQLP 149 Query: 209 FPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTV 268 ++ M ++ + S P D + R +L V Sbjct: 150 EDDADAVMEAMFEAM-----LMQSAEPAD----------GDVDRAAVAFG----YLSARV 190 Query: 269 QEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISW 328 E +D N + +L ++ G I + + + + + G + I+ Sbjct: 191 AEMLEDKRVNPGDGLADSLLDAARAGE------ITESEAIATILVFYAVGHMAIGYLIAS 244 Query: 329 SLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPH 388 + +PE+ + + A I E R + Sbjct: 245 GIELFARRPEVFTAFRNDESARA------------------AIINEMVRMDPP-QLSFLR 285 Query: 389 STTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKM 448 T D + G I + N DPE+++DP F R P + + Sbjct: 286 FPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTR----------PPAASRN 335 Query: 449 MLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480 + FG+G C G+++++ E A+L ++ E Sbjct: 336 LSFGLGPHSCAGQIISRAEATTVFAVLAERYE 367 >4TX3-A nrPDB Length = 404 Score = 128 bits (321), Expect = 6e-30, Method: Composition-based stats. Identities = 58/394 (14%), Positives = 111/394 (28%), Gaps = 76/394 (19%) Query: 90 RLDTIRQALVRQGDDFKGRPDLYTSTLI----TDGQSLTFSTDSGPVWAARRRLAQNALN 145 +RQ L F R I RL L Sbjct: 53 GHAVVRQVLGDH-KRFSTRRRFDRRDEIGGTGVFRPRELVGNLMDYDPPEHTRLRH--LL 109 Query: 146 TFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCF 205 T + +EE V+ A+ AGP P + + + V GA+ Sbjct: 110 TPGFTQRRMRRLAPRIEEIVTDRLDAM------EQAGP----PADLIELFADEVPGAVLC 159 Query: 206 GQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQ 265 D+ + ++ H ++ + S ++ A + F +L Sbjct: 160 ELIGVPRDDQAM-FLQLCHRHLDASLSA-----------------RKRAAAGEAFARYLV 201 Query: 266 KTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTA 325 + +D G++ G+ I E++ + + AG D V+ Sbjct: 202 AMMARERKD----PGDGFIGSIVA-------EHGDTITDEELRGVCVQLMLAGDDNVSGM 250 Query: 326 ISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFT 385 I ++ L+ PE ++ + + + + E R+ + Sbjct: 251 IGLGVLALLRHPEQIAALRGDDQS------------------ADRAVDELIRYLTVPYAP 292 Query: 386 IPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLS 445 P + D + I + V + N D L D R Sbjct: 293 TPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR------------TP 340 Query: 446 EKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 + FG G C+G L + ++ + L ++ Sbjct: 341 VPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRF 374 >3IVY-A nrPDB Length = 433 Score = 127 bits (320), Expect = 9e-30, Method: Composition-based stats. Identities = 50/272 (18%), Positives = 84/272 (30%), Gaps = 55/272 (20%) Query: 225 EFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFL----------------WFLQKTV 268 +FVE S PL L +P + ++ L Sbjct: 165 DFVEQVSCELPLQAIAGLLGVPQEDRGKLFHWSNEMTGNEDPEYAHIDPKASSAELIGYA 224 Query: 269 QEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISW 328 + ++ KN DI L + G + ++ V + AG +T +I+ Sbjct: 225 MKMAEEKAKNPADDIVTQLIQA-----DIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQ 279 Query: 329 SLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPH 388 +M P+ + + R +D E R ++ + Sbjct: 280 GMMAFAEHPDQWE--------LYKKVRPETAAD------------EIVRWATPVT-AFQR 318 Query: 389 STTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKM 448 + RD L+G I K V + N D E+++DP F R Sbjct: 319 TALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILR------------NPNPH 366 Query: 449 MLFGM-GKRRCIGEVLAKWEIFLFLAILLQQL 479 + FG G CIG LA+ I L + + Sbjct: 367 VGFGGTGAHYCIGANLARMTINLIFNAVADHM 398 >5H1Z-A nrPDB Length = 407 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 44/303 (14%), Positives = 94/303 (31%), Gaps = 57/303 (18%) Query: 221 KNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF-LQKTVQEHYQDFD--- 276 ++V+T S IL P ++ ++ L K + + Sbjct: 136 NTPFDWVDTVSVELTTQMLAILFDFPWEERRKLTFWSDWAGDIELVKNEELRLERLRHMY 195 Query: 277 ---------------KNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDT 321 K D+ + + + Q + + + + G DT Sbjct: 196 ECGGYFQNLWNAKIGKPPTPDLISMMIH------SDAMAEMDQMEFLGNLILLIVGGNDT 249 Query: 322 VTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSF 381 +S L P+ + K++ + + + E R + Sbjct: 250 TRNTMSAVAYGLDLFPDQRAKLEADPSMI------------------PNTVQEIIRWQTP 291 Query: 382 LPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAIN 441 L + + T D+ L G I + + N D ++E+ +R Sbjct: 292 LAH-MRRTATVDSELEGQQIKAGDKLALWYISANRDESVFENADRIIVDR---------- 340 Query: 442 KPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILL-QQLEFSVP-PGVKVDLTPIYGLTM 499 P + + + FG G RC+G LA+ +I + L + +++ +V +V ++G Sbjct: 341 -PNARRHLAFGHGIHRCVGARLAELQIAVLLEEMAKRRMRVNVLGEPERVAACFVHGYRK 399 Query: 500 KHA 502 Sbjct: 400 LPV 402 >1UE8-A nrPDB Length = 367 Score = 126 bits (317), Expect = 2e-29, Method: Composition-based stats. Identities = 44/274 (16%), Positives = 89/274 (32%), Gaps = 41/274 (14%) Query: 215 EMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQK-----TVQ 269 ++LS + + +E+ + P+ + + NP +++ K ++ L + ++ Sbjct: 103 KLLSELDEEFDVIESFAIPLPILVISKMLGI-NPDVKKVKDWSDLVALRLGRADEIFSIG 161 Query: 270 EHYQDFDKNSVRDITGALFKHSKKGPRASGNL-IPQEKIVNLVNDIFGAGFDTVTTAISW 328 Y + S +++ K N + + + + AG +T T I Sbjct: 162 RKYLELISFSKKELDSRKGKEIVDLTGKIANSNLSELEKEGYFILLMIAGNETTTNLIGN 221 Query: 329 SLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPH 388 ++ E T+ R + + E R S + Sbjct: 222 AI---------------EDFTLYNSWDYVREKGALK------AVEEALRFSPPV-MRTIR 259 Query: 389 STTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKM 448 T + I + V V N D E+++DP F P+R Sbjct: 260 VTKEKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSFIPDR------------TPNPH 307 Query: 449 MLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFS 482 + FG G C+G LA+ E + L ++ Sbjct: 308 LSFGSGIHLCLGAPLARLEARIALEEFAKKFRVK 341 >5LIV-A nrPDB Length = 450 Score = 126 bits (317), Expect = 2e-29, Method: Composition-based stats. Identities = 55/389 (14%), Positives = 121/389 (31%), Gaps = 75/389 (19%) Query: 97 ALVRQGDDFKGRPDLYTSTLITDGQSLT---FSTDSGPVWAARRRLAQNALNTFSIASDP 153 L+R+ D T + + + G A RR+ +++ Sbjct: 92 ILLRKSHITTAYRDTATFSTRMFQAGILNGGLAAMQGDEHARMRRVYNMFFLPRAVSQYE 151 Query: 154 ASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFG---QHFP 210 + + + ++ + +AG D + + + FG + Sbjct: 152 E------------RFVRPISEQVVDRLAGKPRVDLLEDFAMELPRRVIGELFGFPAEKLH 199 Query: 211 ESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQE 270 E+ + + ++++ + A+ + L + + V+ Sbjct: 200 ETDERVRAMLRGLVRMHDPAAVAES------------------QRAYGETLGLITEVVER 241 Query: 271 HYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSL 330 RD + L + +A + E +V + G++T + ++ ++ Sbjct: 242 --------ESRDTSDTLLGEILRTLKAEH-MDTIEASRQIVLSLILGGYETTSWLVANTI 292 Query: 331 MYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHST 390 L+ P+ +++++ L A I E R F + Sbjct: 293 HALLAHPDTLARVRQDP------------------SLLPAAIEEGMRWCP-SSFGVLRMV 333 Query: 391 TRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMML 450 RD L+ + V + N+D + P + +R KPL + Sbjct: 334 ERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDR----------KPLPAANV- 382 Query: 451 FGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 FG G C+G LA+ E + L LL + Sbjct: 383 FGGGAHFCVGAPLARMEARVGLQALLARF 411 >4DO1-A nrPDB Length = 410 Score = 126 bits (317), Expect = 2e-29, Method: Composition-based stats. Identities = 50/294 (17%), Positives = 93/294 (31%), Gaps = 45/294 (15%) Query: 205 FGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFL 264 F DE+L + + + + PL FP L + + Sbjct: 129 FAAAADAKVDELLQ--RGCIDAIADLAEAYPLSVFPDAMGLKQEGREHLLPYAGLVFNAF 186 Query: 265 QKTVQEHYQDFDKNSVR-----------DITGALFKHSKKGPRASGNLIPQEKIVNLVND 313 + ++++ ++ F +G + P E + LV Sbjct: 187 GPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEITPDEAPL-LVRS 245 Query: 314 IFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFIL 373 + AG DT I ++ L P ++++ + Sbjct: 246 LLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDP------------------TLARNAFE 287 Query: 374 ETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL 433 E R S + T +TTR+ L G I + V + N DP W DP + R Sbjct: 288 EAVRFESPVQ-TFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITR-- 344 Query: 434 TADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV 487 + + FG G C+G+++A+ E + L+ L +++ G Sbjct: 345 ----------KTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDGP 388 >4PWV-A nrPDB Length = 446 Score = 126 bits (315), Expect = 4e-29, Method: Composition-based stats. Identities = 51/304 (16%), Positives = 88/304 (28%), Gaps = 56/304 (18%) Query: 225 EFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFL----------------WFLQKTV 268 +F + PL+ L +P + N+ L + Sbjct: 167 DFAADVAEQIPLNTISDLLGVPAADREFLLKLNKSALSSEDADQSATDAWLARNEILLYF 226 Query: 269 QEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISW 328 E + D+ L G + +E IV + G +T ++ Sbjct: 227 SELVAERRAKPTEDVISVL-----ANSMVDGKPLTEEVIVLNCYSLILGGDETSRLSMID 281 Query: 329 SLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPH 388 S+ P+ ++ T LE+ E R ++ Sbjct: 282 SVQTFTQYPDQWELLRDGKVT------------------LESATEEVLRWATPA-MHFGR 322 Query: 389 STTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKM 448 D L+G I V + N D E++ DP F R K Sbjct: 323 RAVTDMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDLNR------------SPNKH 370 Query: 449 MLFGMGKRRCIGEVLAKWEIFLFLAIL---LQQLEFSVPPGVKVDLTPIYGLTMKHARCE 505 + FG G C+G L + E+ L L E + P ++ + GL+ R + Sbjct: 371 ITFGYGPHFCLGAYLGRAEVHALLDALRTYTTGFEITGEP-QRIHSNFLTGLSRLPVRIQ 429 Query: 506 HVQA 509 +A Sbjct: 430 PNEA 433 >6F88-A nrPDB Length = 400 Score = 125 bits (314), Expect = 4e-29, Method: Composition-based stats. Identities = 55/389 (14%), Positives = 121/389 (31%), Gaps = 75/389 (19%) Query: 97 ALVRQGDDFKGRPDLYTSTLITDGQSLT---FSTDSGPVWAARRRLAQNALNTFSIASDP 153 L+R+ D T + + + G A RR+ +++ Sbjct: 42 ILLRKSHITTAYRDTATFSTRMFQAGILNGGLAAMQGDEHARMRRVYNMFFLPRAVSQYE 101 Query: 154 ASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFG---QHFP 210 + + + ++ + +AG D + + + FG + Sbjct: 102 E------------RFVRPISEQVVDRLAGKPRVDLLEDFAMELPRRVIGELFGFPAEKLH 149 Query: 211 ESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQE 270 E+ + + ++++ + A+ + L + + V+ Sbjct: 150 ETDERVRAMLRGLVRMHDPAAVAES------------------QRAYGETLGLITEVVER 191 Query: 271 HYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSL 330 RD + L + +A + E +V + G++T + ++ ++ Sbjct: 192 --------ESRDTSDTLLGEILRTLKAEH-MDTIEASRQIVLSLILGGYETTSWLVANTI 242 Query: 331 MYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHST 390 L+ P+ +++++ L A I E R F + Sbjct: 243 HALLAHPDTLARVRQDP------------------SLLPAAIEEGMRWCP-SNFGVLRMV 283 Query: 391 TRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMML 450 RD L+ + V + N+D + P + +R KPL + Sbjct: 284 ERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDR----------KPLPAANV- 332 Query: 451 FGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 FG G C+G LA+ E + L LL + Sbjct: 333 FGGGAHFCVGAPLARMEARVGLQALLARF 361 >5L1U-A nrPDB Length = 401 Score = 125 bits (314), Expect = 4e-29, Method: Composition-based stats. Identities = 58/434 (13%), Positives = 107/434 (24%), Gaps = 99/434 (22%) Query: 70 QRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDS 129 Q+ G + ++ +++R D +R L + ++ + + Sbjct: 28 QKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKSAARAFMVALAAGD 87 Query: 130 GPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPY 189 R +L ++ +E HV + L + Sbjct: 88 DHETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDELLDQLAAS-------------- 133 Query: 190 NQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPA 249 + S P L +P Sbjct: 134 -------------------------------APPVDLHRVLSFRLPTMVVCDLLGVPLAD 162 Query: 250 LQRFKAFNQRFLWF------------LQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRA 297 +RF + + + + E DI L Sbjct: 163 RERFGQWARGTFDQSDNEHSANTFQQVVDYMLELVARKRVEPGDDILSELIAEKDGA--- 219 Query: 298 SGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRP 357 + I +L N + G++T I + L+ P + ++ ++ Sbjct: 220 ----LSDADIAHLGNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAEDPG--------- 266 Query: 358 RLSDRPQLPYLEAFILETFRHSSFLP---FTIPHSTTRDTTLNGFYIPKKCCVFVNQWQV 414 A + E R IP D T+ I V + Sbjct: 267 ---------LAPAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAA 317 Query: 415 NHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAI 474 N+D + D F R + FG G R CIG LA+ E+ Sbjct: 318 NYDDRAFPDGGLFDLTR-----------VRPRSHLAFGHGARHCIGRTLARIELTAVFER 366 Query: 475 LLQQ---LEFSVPP 485 L ++ L +VP Sbjct: 367 LFRRLPDLRLAVPE 380 >6GII-A nrPDB Length = 479 Score = 125 bits (313), Expect = 6e-29, Method: Composition-based stats. Identities = 70/463 (15%), Positives = 148/463 (31%), Gaps = 82/463 (17%) Query: 57 LGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTL 116 +P + ++ + V++R DTI+Q R F L + Sbjct: 76 YMADPAQFVRWAREQV-PIF--YAPKLNYWVVTRYDTIKQIF-RDPVTFSPSNVLQSFAQ 131 Query: 117 IT-------DGQSLTFS----TDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHV 165 + + F+ + P+ RRR+ AS+ + + E V Sbjct: 132 PSAEVRQVLERYGYAFNRTLVNEDEPMHLERRRVLMEPF-----ASEHLAEHEPMVRELV 186 Query: 166 SKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHE 225 + I G D +Q++ V + G + E + H Sbjct: 187 RRAVNRFIDT--------GRADLVDQMIWEVPFTVALHFLG--VDDDDREKMRRFAIAH- 235 Query: 226 FVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITG 285 R P L + Q F F + +++ + D Sbjct: 236 -----------TVNAFGRPSPEEQLAVAETVGQ-FWQFCGEVLEKMRRTADGPGW----- 278 Query: 286 ALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQK 345 ++S + + +++ + +++ I A +T A + +L L+ + R+I Sbjct: 279 --MRYSIRQQKLYPDVVTDSYLHSMMQAIIVAAHETTVFATTNALKTLLEHETVWREICA 336 Query: 346 ELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKC 405 + + A E R++ + TTR+ + G +P Sbjct: 337 DP------------------SLIPAAAEECLRYNGPVA-GWRRRTTREVEVEGVRLPVGA 377 Query: 406 CVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAK 465 + + NHD ++DP F R + + + FG G +C+G L + Sbjct: 378 NILMVVASANHDSAHFDDPEFFDIGR-----------SNASEHLNFGYGAHQCLGRNLGR 426 Query: 466 WEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQ 508 E+ + + L ++L + D ++ ++ + R V+ Sbjct: 427 MEMQIMIEELSRRLPHMRLAEQRFDY--LHNVSFRAPRHLWVE 467 >6HQD-A nrPDB Length = 420 Score = 124 bits (312), Expect = 7e-29, Method: Composition-based stats. Identities = 66/430 (15%), Positives = 133/430 (30%), Gaps = 60/430 (13%) Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTF--STDSGPVWAARRRLAQNAL-NTFSIASDPAS 155 V + + F+ + + + +++ GP W+ + A+ + S + Sbjct: 23 VSKPELFERDGLHPYFERLRREDPVHYCKASEYGPYWSITKFSDIVAIDTNHKVFSSDHT 82 Query: 156 SSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDE 215 + S L++ I L P D + VV + + F E + Sbjct: 83 NGSFVLDDTTLNAVDGGIYLPNFLGMDPPKHDVHRMVVSPIVAPQNLLRFEATIRERTKR 142 Query: 216 MLSLVKNTHEF--VETASSGNPLDFFPILRYLPNPALQRFKAFNQRFL------------ 261 +LS + EF V+ S L P ++ ++ Sbjct: 143 VLSELPIGEEFNWVDRVSIELTTMMLATLLDFPFDDRRKLTRWSDIITTRPGYGLVDSWE 202 Query: 262 ---WFLQK---TVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIF 315 L + Q Y + + ++ HS + + + + + Sbjct: 203 QRESELMECLAYFQRLYAERQAMPPKPDLISMLAHSPEMQD-----LTPTDFLGTLALLI 257 Query: 316 GAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILET 375 G DT +++S S M P+ K++ L + I E Sbjct: 258 VGGNDTTRSSMSGSAMACHLYPQEFDKVRNNR------------------ALLASVIPEV 299 Query: 376 FRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTA 435 R + + + + D G I K V + N D E+ + P +F +R Sbjct: 300 VRWQTPIAH-MRRTALEDVEFRGKQIRKGDKVVMWYLSGNRDDEVIDRPMDFIADR---- 354 Query: 436 DGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDL--TP 493 P + + FG G RC+G LA+ ++ + + ++ G V + Sbjct: 355 -------PRARHHLSFGFGIHRCLGNRLAELQLKILWEEMCERYSRIEVCGEPVRVPSNL 407 Query: 494 IYGLTMKHAR 503 ++G R Sbjct: 408 VHGYIDIPVR 417 >6M7L-A nrPDB Length = 404 Score = 124 bits (311), Expect = 9e-29, Method: Composition-based stats. Identities = 43/284 (15%), Positives = 84/284 (29%), Gaps = 49/284 (17%) Query: 225 EFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEH-----YQDFDKNS 279 EF+ + +P ++ + H ++ Sbjct: 150 EFLREVAGPMAARVACEFLGIPLDDRGELIRLTAHRGGKRRRVLNGHAYLAYMRELAARL 209 Query: 280 VRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEI 339 RD + R G I E++ L + + + + ++ + L+ PE Sbjct: 210 RRDPGDGMLGMVA---RDHGADISDEELAGLCAVVMNSSVEQTESCLAAGTLLLLEHPEQ 266 Query: 340 QRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGF 399 +++ + E + E R+ S P + T D + G Sbjct: 267 FALLRERPE------------------LGEQAVEEIVRYLSVFEGLDPRTATEDVEIGGQ 308 Query: 400 YIPKKCCVFVNQWQVNH-DPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRC 458 I K VF + N DP L F R + + FG G C Sbjct: 309 VIKKGEAVFCSLLAANRADPAL----DGFDITR------------KESRHVAFGHGIHHC 352 Query: 459 IGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHA 502 +G LA+ E+ + L+ + P ++ + P + + Sbjct: 353 LGAPLARMELRIAFTTLVSRF-----PSLRTAV-PAEEIRFRPP 390 >2UUQ-A nrPDB Length = 414 Score = 122 bits (307), Expect = 3e-28, Method: Composition-based stats. Identities = 44/283 (15%), Positives = 81/283 (28%), Gaps = 52/283 (18%) Query: 225 EFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLW----------------FLQKTV 268 + V P +P +F + Q + + Sbjct: 145 DIVTELFKPLPSMVVAHYLGVPEEDWTQFDGWTQAIVAANAVDGATTGALDAVGSMMAYF 204 Query: 269 QEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISW 328 + D L + + I+ + G DTVT + Sbjct: 205 TGLIERRRTEPADDAISHLVAAGVGADGDTAGTLS---ILAFTFTMVTGGNDTVTGMLGG 261 Query: 329 SLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPH 388 S+ L +P+ +R + + + + + E R +S + + Sbjct: 262 SMPLLHRRPDQRRLLLDDPEGI------------------PDAVEELLRLTSPVQ-GLAR 302 Query: 389 STTRDTTLNGFYIPKKCCVFVNQWQVNHDPELW-EDPSEFRPERFLTADGTAINKPLSEK 447 +TTRD T+ IP V + N D + D +E R Sbjct: 303 TTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTR------------CPRN 350 Query: 448 MMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL-EFSVPPGVKV 489 ++ F G C+G A+ + + L LL + +F V V Sbjct: 351 ILTFSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESRIV 393 >5HH3-A nrPDB Length = 397 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 71/400 (17%), Positives = 118/400 (29%), Gaps = 81/400 (20%) Query: 81 GSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLA 140 G + + D IRQ L DDF R LY T + P RR+ Sbjct: 50 GGRTAWLATGYDEIRQVL--SSDDFSARL-LYGGTAAGITWPGFLTQYDPPEHTRLRRMV 106 Query: 141 QNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVI 200 A + +E V A+ E + GP F P V+ Sbjct: 107 APAFAVRRMQKFQ-----PQVERVVQDSLDAI-----EALGGPVDFVPRFGWSVATT--- 153 Query: 201 GAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRF 260 F + ++ + + T SG +R A +F Sbjct: 154 ATCDFLGIPRDDQADLARSLHAS----RTERSG-----------------KRRTAAGNKF 192 Query: 261 LWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFD 320 + ++ K +D D+ G + + G+ I ++ + + GAG D Sbjct: 193 MTYMNKMTARTRRD----PGDDMFGVVVREY-------GDEITDAELTGVAAFVMGAGAD 241 Query: 321 TVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSS 380 V ++ + PE ++++ DTV P D E R+ + Sbjct: 242 QVARFLAAGAWLMADDPEQFALLREKPDTV------PDWLD------------EVIRYLT 283 Query: 381 FLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDP-SEFRPERFLTADGTA 439 T P T D + I V + N + P F R Sbjct: 284 TDEKTHPRVATDDVRIGDHLIKAGDTVTCSLLAANR--RNFPRPEDRFDITR-------- 333 Query: 440 INKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 + + + FG G C+G LA+ + L + Sbjct: 334 ----VRPEHLAFGHGIHHCLGRSLAELVFRTAIPALAHRF 369 >2X9P-A nrPDB Length = 404 Score = 121 bits (303), Expect = 9e-28, Method: Composition-based stats. Identities = 69/455 (15%), Positives = 128/455 (28%), Gaps = 91/455 (20%) Query: 65 LSRMSQRYGDVLQIRI-GSTPVLVLSRLDTIRQALVRQ--GDDFKGRPDLYTSTLITDGQ 121 L R Q G + ++R +++R ++Q L + G P Sbjct: 31 LLRALQDRGPIHRVRTPAGDEAWLVTRHAELKQLLHDERIGRTHPDPPSAAQYVRSPFLD 90 Query: 122 SLTFSTDSGPVWAAR---RRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQE 178 L D+ RRL + + ++ V + A L+ Sbjct: 91 LLISDADAESGRRQHAETRRLLTPLFSARRVLE---------MQPKVEEAADTLLDAFIA 141 Query: 179 LMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDF 238 PG V ++ V+ + + E + LD Sbjct: 142 -QGPPGDLHGELTVPFALT-VLCEVI------------GVPPQRRAELTTLLAGIAKLD- 186 Query: 239 FPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRAS 298 + ++ V+ DI L + Sbjct: 187 ----------DREGAVRAQDDLFGYVAGLVE----HKRAEPGPDIISRL----------N 222 Query: 299 GNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPR 358 + ++++ +L + AG D+V + + ++ L P+ + + D Sbjct: 223 DGELTEDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAAALADPD---------- 272 Query: 359 LSDRPQLPYLEAFILETFRHSSFLPFTIP-HSTTRDTTLNGFYIPKKCCVFVNQWQVNHD 417 + + E R + +P + D G I V + N D Sbjct: 273 --------VMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFD 324 Query: 418 PELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQ 477 + P EF R + FG G CIG LA+ E+ L Sbjct: 325 ERAFTGPEEFDAAR------------TPNPHLTFGHGIWHCIGAPLARLELRTMFTKLFT 372 Query: 478 QLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLR 512 +L P ++ +L P+ L +K + A LR Sbjct: 373 RL-----PELRPEL-PVEQLRLKEGQLSGGFAELR 401 >6G71-A nrPDB Length = 405 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 71/438 (16%), Positives = 136/438 (31%), Gaps = 76/438 (17%) Query: 53 HVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLY 112 H+ L +NP R+ V + +++ + A V Q F Sbjct: 15 HLADLYQNPFPIFERLRSE-SPVAWVPEAGR--YLITSYSGVLAADVDQ-TTFSANEK-K 69 Query: 113 TSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKAL 172 + L G S+ D P RR Q +L ++ E+ + A Sbjct: 70 SLMLRAMGHSMLRKDD--PDHQVERRAWQPSLKPGTVKK----VWKQKFAENADRYLDAY 123 Query: 173 ISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASS 232 I F N+ + F + + ++ + + + Sbjct: 124 IDA-----GSGSDFMQGFAAPFVAENLRALIGF-------ENASEADLQRWSQTLIDGAG 171 Query: 233 GNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSK 292 P D + K + L++ +Q H + L Sbjct: 172 NYPDDPDVW---------AKAKQSSDEIDAALEEMIQWH----SGRPGDSLLSYLL---- 214 Query: 293 KGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG 352 R++ +P E I + + G G + + S + L++ + + ++ Sbjct: 215 ---RSADYQMPLESIRSNIKMTIGGGLNEPRDVLGVSTLALLSSSKQLELVLRDPK---- 267 Query: 353 RERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQW 412 A E+ R + + +P T DT L+G++IP+ + + Sbjct: 268 --------------LWGAVFEESIRWVAPIGM-VPRQTVVDTELDGYFIPRGAKLGLCIL 312 Query: 413 QVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIF-LF 471 N D +W DP F ER SE + FG G C+G A+ ++ + Sbjct: 313 SANRDRSVWSDPDRFDIER------------GSEAHLAFGKGVHVCLGAWAARSQVADVG 360 Query: 472 LAILLQQLE-FSVPPGVK 488 L L +L+ + P + Sbjct: 361 LPALFSRLKGLRLDPNQE 378 >3WEC-A nrPDB Length = 419 Score = 119 bits (297), Expect = 4e-27, Method: Composition-based stats. Identities = 43/293 (14%), Positives = 84/293 (28%), Gaps = 48/293 (16%) Query: 220 VKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQK--TVQEHYQDFDK 277 +++ + V + P++ + +P+ RF ++ L + + D Sbjct: 142 LEHCTDAVSEVAEPFPVEVLSSILGIPDKDRGRFSEWSNLVAGVLDINFAIPKEVADRRS 201 Query: 278 NSVRDITGAL------------FKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTA 325 ++ + G+ + ++I I AG +T + Sbjct: 202 AAIEESIDYFRTLATSGNAPEGLVRRLSEVSHGGDQLSVDEIAATCLLITVAGQETTSNT 261 Query: 326 ISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFT 385 I L+ + +++ ++E + E R Sbjct: 262 IGNMLITFSRHADQFEQVRANPQ------------------FIENAVAEVLRFEPPA-HE 302 Query: 386 IPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLS 445 D ++G I K V V N E E F R Sbjct: 303 AGRIALEDCEVSGANITKGDAVMVLLASGNR--EAVERGDTFSVTR------------PD 348 Query: 446 EKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLT 498 + +G G C+G LA + FL L Q+ S+ ++ P GL Sbjct: 349 VSSLSYGRGIHHCLGSALANSMLQHFLRELSQRYR-SIEVAEPINYKPGMGLR 400 >2NZA-A nrPDB Length = 413 Score = 118 bits (296), Expect = 5e-27, Method: Composition-based stats. Identities = 46/281 (16%), Positives = 95/281 (33%), Gaps = 56/281 (19%) Query: 225 EFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWF-------------LQKTVQEH 271 + VE P+ + +P +R ++ ++ + L + E Sbjct: 146 DLVERVLEPFPIAVVSEVMGVPAADRERVHSWTRQIISTSGGAEAAERAKRGLYGWITET 205 Query: 272 YQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLM 331 + + D+ L +G + + + V L + G + VT + L Sbjct: 206 VRARAGSEGGDVYSMLGAAVGRGE------VGETEAVGLAGPLQIGG-EAVTHNVGQMLY 258 Query: 332 YLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSF-LPFTIPHST 390 L+T+ E+ ++++ + E R S + Sbjct: 259 LLLTRRELMARMRERPGAR------------------GTALDELLRWISHRTSVGLARIA 300 Query: 391 TRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMML 450 D ++G I V+V+ N DP+++ DP +R + Sbjct: 301 LEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDRD------------PNPHLA 348 Query: 451 FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDL 491 +G G C G VLA+ + L + LL++L PG+++ + Sbjct: 349 YGNGHHFCTGAVLARMQTELLVDTLLERL-----PGLRLAV 384 >1WIY-A nrPDB Length = 389 Score = 116 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 71/455 (15%), Positives = 147/455 (32%), Gaps = 88/455 (19%) Query: 48 WPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKG 107 WP L L ++P L + + + + + P+ ++ + + AL+ +G Sbjct: 10 WPYL---KDLQQDPLAVLLEWGRAHPRLF-LPLPRFPLALIFDPEGVEGALLAEGTTKA- 64 Query: 108 RPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSK 167 + ++ TD G W R+ ++ S+ E + + Sbjct: 65 ---TFQYRALSRLTGRGLLTDWGKSWKEARKALKDPFLPKSVRG---------YREAMEE 112 Query: 168 EAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFV 227 EA A + D ++++ ++G FG+ S E +K + Sbjct: 113 EAWAFFGEWR-----GEERDLDHEMLALSLRLLGRALFGKPLSPSLAE--HALKALDRIM 165 Query: 228 ETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGAL 287 S L A RF+ + + Sbjct: 166 AQTRSPLALLD--------LAAEARFRKDRGALYREAEALI------------------- 198 Query: 288 FKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKEL 347 + +P+E+ ++ + AG +TV +A++WS + L +P+ Q+++ Sbjct: 199 -------VHPPLSHLPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRV---- 247 Query: 348 DTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCV 407 A E R + + R L +P+ + Sbjct: 248 --------------AESEEAALAAFQEALRLYPPA-WILTRRLERPLLLGEDRLPQGTTL 292 Query: 408 FVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWE 467 ++ + + + F+PERFL GT S + FG+G+R C+G A E Sbjct: 293 VLSPYVTQR--LYFPEGEAFQPERFLAERGTP-----SGRYFPFGLGQRLCLGRDFALLE 345 Query: 468 IFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHA 502 + L ++ P +V + +T++ Sbjct: 346 GPIVLRAFFRRFRLDPLPFPRV----LAQVTLRPE 376 >5EX8-A nrPDB Length = 424 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 77/466 (16%), Positives = 134/466 (28%), Gaps = 110/466 (23%) Query: 45 PWGWPLLG-----HVLTLGKNPHLALSRM----------SQRYGDVLQIR----IGSTPV 85 P PLLG ++ G +P + R+ V ++ G V Sbjct: 10 PIPNPLLGLDSTENLYFQGIDPFTMFEEINVVRASQLHRRDRFDPVPELHSLMKEGGLTV 69 Query: 86 L------------VLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVW 133 L + + +D +RQ L D F R LY T + P Sbjct: 70 LGTEDSTEGRTAWLATGIDEVRQVLG--SDKFSARL-LYGGTAAGITWPGFLTQYDPPEH 126 Query: 134 AARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVV 193 RR+ A + + +E+ V + E + GP F P+ Sbjct: 127 TRLRRMVVPAFSHRRMQKF-----RPRVEQIVQDSLDTI-----ESLGGPVDFVPHFGWA 176 Query: 194 VSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRF 253 ++ A C P L+ R L R Sbjct: 177 IATP----ATCDFLGIPRDDQADLA------------------------RILLASRTDRS 208 Query: 254 KAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVND 313 +++H + S D+ G + R +G+ I ++ + Sbjct: 209 DKRRTAAGNKFMTYMKQHVAQSRRGSGDDLFGIV-------GRENGDAITDAELTGVAAF 261 Query: 314 IFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFIL 373 + GA D V ++ +V +P ++++ +TV P D Sbjct: 262 VMGAAADQVARLLAAGAWLMVEQPAQFALLREKPETV------PEWLD------------ 303 Query: 374 ETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL 433 ET R+ + T P T+D + + V + N P EF R Sbjct: 304 ETMRYLTTDEKTHPRVATQDVRIGNQLVKAGDTVTCSLLAANR-PNYPSAEDEFDITREK 362 Query: 434 TADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 + FG G C+G +A+ + + L + Sbjct: 363 AE------------HLAFGHGIHHCLGRAMAELMFKVSIPALAHRF 396 >3OO3-A nrPDB Length = 384 Score = 112 bits (281), Expect = 3e-25, Method: Composition-based stats. Identities = 55/316 (17%), Positives = 100/316 (31%), Gaps = 65/316 (20%) Query: 211 ESSDEMLSLVKNTHEFVE-----TASSGNPLDFFPILRYLPNPALQRFK--AFNQRFLWF 263 S+ M L E VE S G P+DF + P PA + + Sbjct: 98 YSARRMERLRPRIEEIVEECLDDFESVGAPVDFVRHAAW-PIPAYIACEFLGVPRDDQAE 156 Query: 264 LQKTVQEHYQDFDKNSVR-------DITGALFKHSKKGP---------RASGNLIPQEKI 307 L + ++E + + T L ++ P R G I E++ Sbjct: 157 LSRMIRESRESRLPRQRTLSGLGIVNYTKRLTSGKRRDPGDGMIGVIVREHGAEISDEEL 216 Query: 308 VNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPY 367 L + + ++ +++ LVT P+ +++ + Sbjct: 217 AGLAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLRE------------------KPEL 258 Query: 368 LEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEF 427 +++ E RH+S + P D + G I + + N P F Sbjct: 259 IDSATEEVLRHASIVEAPAPRVALADVRMAGRDIHAGDVLTCSMLATNRAPG-----DRF 313 Query: 428 RPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV 487 R M FG G CIG LA+ ++ + L ++ + P + Sbjct: 314 DITR------------EKATHMAFGHGIHHCIGAPLARLQLRVALPAVVGRF-----PSL 356 Query: 488 KVDLTPIYGLTMKHAR 503 ++ + P L K R Sbjct: 357 RLAV-PEEDLRFKPGR 371 >2IAG-A nrPDB Length = 482 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 97/514 (18%), Positives = 179/514 (34%), Gaps = 67/514 (13%) Query: 29 KGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVL 88 + RP P P + P LG+ L GK+ L+RM +++GD+ I +G V VL Sbjct: 1 RTRRPGEP-----PLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVL 55 Query: 89 SRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFS 148 + A+V + T + F R+ L +S Sbjct: 56 LDPHS-YDAVVWE-----------PRTRLDFHAYAIFL---------MERIFDVQLPHYS 94 Query: 149 IASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ- 207 + + A L + +A+ + L ++ G + + + + Sbjct: 95 PSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAG 154 Query: 208 HFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRF----KAFNQRFLWF 263 + E L + S+ F + R LP A K Sbjct: 155 YLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSR 214 Query: 264 LQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVT 323 L K + + + + L + G + +E + A + Sbjct: 215 LWKLLSPARLARRAHRSKWLESYLLHLEEMG-------VSEEMQARALVLQLWATQGNMG 267 Query: 324 TAISWSLMYLVTKPEIQRKIQKELDTVIGRERRP--RLSDRPQL-----PYLEAFILETF 376 A W L++L+ PE ++ EL++++ + +P + + PQ P L++ + E+ Sbjct: 268 PAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESL 327 Query: 377 RHSSFLPFTIPHSTTRDTTL-----NGFYIPKKCCVFVNQ-WQVNHDPELWEDPSEFRPE 430 R + PF I D + F + + + + DPE++ DP F+ Sbjct: 328 RL-TAAPF-ITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYN 385 Query: 431 RFLTADGTAIN------KPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVP 484 RFL DG+ K L M +G G C+G A I F+ ++L L+ + Sbjct: 386 RFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELI 445 Query: 485 PGVKVDLTPIYGLT------MKHARCEHVQARLR 512 V++ P + L+ M+ V+ R+R Sbjct: 446 -NADVEI-PEFDLSRYGFGLMQPEHDVPVRYRIR 477 >5D3U-A nrPDB Length = 427 Score = 109 bits (272), Expect = 3e-24, Method: Composition-based stats. Identities = 62/408 (15%), Positives = 122/408 (29%), Gaps = 69/408 (16%) Query: 105 FKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEH 164 F G+P + +++ TD P+ A RR + ++ + ++ Sbjct: 89 FPGQPLPPDNIFHRWTKNVVMYTDP-PLHDALRRSVRAGFT---------RAAHQHYDQV 138 Query: 165 VSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTH 224 + K A L++ + AG D + + FG PE L+ + Sbjct: 139 LQKVAHDLVASIP---AGATEIDAVPALAAELPVRSAVHAFG--VPEEDLGF--LIPRVN 191 Query: 225 EFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDIT 284 + S + L L E Q + D Sbjct: 192 TIMTYFSGP--------------KDQPVTQEIILEKLTDLHTYASELLQGMRGKVLPDTV 237 Query: 285 GALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQ 344 A ++ G + ++ + +F T ++S + P + Sbjct: 238 IARLAAAQDGLTETTPEQTVHQLALVFIALFAP---TTPGSLSSGTLAFARNPRQVERFL 294 Query: 345 KELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKK 404 + V + E R+++ FT +D + G I Sbjct: 295 ADQACV------------------DNTANEVLRYNASNQFT-WRVAAKDVEMGGVRIEAG 335 Query: 405 CCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLA 464 + + N D ++E P++F +R P S + + FG G C+ L Sbjct: 336 QTLALFLGSANRDANMFERPNDFDLDR-----------PNSARHLSFGQGVHACLAAQLI 384 Query: 465 KWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLR 512 ++ F LL + PG++ PI+ ++ + LR Sbjct: 385 SLQLKWFYVALLNRF-----PGIRTAGEPIWNENLEFRSLRSLPLSLR 427 >6BLD-A nrPDB Length = 419 Score = 108 bits (269), Expect = 7e-24, Method: Composition-based stats. Identities = 64/382 (16%), Positives = 106/382 (27%), Gaps = 67/382 (17%) Query: 124 TFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGP 183 +F P R+L A +E+ + AK ++ L+ MAG Sbjct: 101 SFLAMDPPRHTKLRKLVSAAFTP---------RQVRRIEDSIKINAKGIVDELR--MAGG 149 Query: 184 GHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILR 243 G + + M PE+ E ++ H S +P R Sbjct: 150 GVDFVEHCAKELPIRTLSDMV---GIPEADRERVA-----HAADALVSWADP-------R 194 Query: 244 YLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIP 303 YL + A +L + + D+ AL G+ + Sbjct: 195 YLNG---REPLAVLFENQMYLHQVAASLAAERRDRPGDDLFSALVNA-----EVDGDRLA 246 Query: 304 QEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRP 363 + + AG DT IS L L P + + + DT IG Sbjct: 247 DADVAAFFVLLAVAGNDTTRQTISHGLKALTDFPSQKAWLLADFDTRIGT---------- 296 Query: 364 QLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWED 423 + E R ++ + T + D L G I V + N D + + Sbjct: 297 -------AVEELVRWATPV-MTFRRTAAADFELGGQLIRAGEKVVMFYASGNWDEDAFCH 348 Query: 424 PSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSV 483 P R + C+G LA+ ++ LL + Sbjct: 349 PERLDLSRSPNPHVGFGGGGVHF-----------CLGAHLARAQLRAIFGELL----VQL 393 Query: 484 PPGVKVDLTPIYGLTMKHARCE 505 P D + G + R Sbjct: 394 PDIQAGDPVYVPGNFVHAIRSM 415 >4FB2-A nrPDB Length = 398 Score = 107 bits (268), Expect = 8e-24, Method: Composition-based stats. Identities = 51/418 (12%), Positives = 118/418 (28%), Gaps = 78/418 (18%) Query: 89 SRLDTIRQALVRQGDDFK-GRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTF 147 +AL + + G + Y + G + V + + + Sbjct: 19 GTPHAFFEALRDEAETTPIGWSEAYGGHWVVAGYKEIQA-----VIQNTKAFSNKGVTFP 73 Query: 148 SIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207 + ++ V K+ + L+++ F P F + Sbjct: 74 RYETGEFELMMAGQDDPVHKKYRQLVAK---------PFSPE-----------ATDLFTE 113 Query: 208 HFPESSDEMLSLVKNTHEFVET--ASSGNPLDFFPILRYLPNPALQRFKAF--------- 256 +S+++++ E ++ P IL LP ++ + Sbjct: 114 QLRQSTNDLIDARIELGEGDAATWLANEIPARLTAILLGLPPEDGDTYRRWVWAITHVEN 173 Query: 257 ---NQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVND 313 L + + N DI + + G + ++ ++ Sbjct: 174 PEEGAEIFAELVAHARTLIAERRTNPGNDIMSRVIM-----SKIDGESLSEDDLIGFFTI 228 Query: 314 IFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFIL 373 + G D +S L E++R++ + + Sbjct: 229 LLLGGIDNTARFLSSVFWRLAWDIELRRRL------------------IAHPELIPNAVD 270 Query: 374 ETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL 433 E R P + T++ T+ + + + D ++ P ER Sbjct: 271 ELLRFY--GPAMVGRLVTQEVTVGDITMKPGQTAMLWFPIASRDRSAFDSPDNIVIER-- 326 Query: 434 TADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL-EFSVPPGVKVD 490 + + G G RC+G L + E + + L+++ EFS+ P + + Sbjct: 327 ----------TPNRHLSLGHGIHRCLGAHLIRVEARVAITEFLKRIPEFSLDPNKECE 374 >3B98-A nrPDB Length = 475 Score = 107 bits (268), Expect = 9e-24, Method: Composition-based stats. Identities = 83/493 (16%), Positives = 170/493 (34%), Gaps = 62/493 (12%) Query: 42 PPEPWG-WPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVR 100 PP G P LGH L GK+ L+RM +++GD+ +R + VL + L Sbjct: 20 PPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVLLDSNCYDAVL-- 77 Query: 101 QGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCY 160 D Y L+ ++ + + R + + +++ ++ Sbjct: 78 -SDVASLDQTSYAQVLMKRIFNMILPSHNPESEKKRAEMHFQGASLTQLSNSMQNNLRLL 136 Query: 161 LEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLV 220 + E S ++ G F+ ++ + FG + + + Sbjct: 137 MTP---SEMGLKTSEWKK----DGLFNLCYSLLFKTGYL---TVFGAE-----NNNSAAL 181 Query: 221 KNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF---DK 277 +E +F + LP A ++ ++ + + K Sbjct: 182 TQIYE-----------EFRRFDKLLPKLARTTVNKEEKQIASAAREKLWKWLTPSGLDRK 230 Query: 278 NSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKP 337 + G+ K + + + ++ L AG A W + YL+T P Sbjct: 231 PREQSWLGSYVKQL-QDEGIDAEMQRRAMLLQLWVTQGNAGP-----AAFWVMGYLLTHP 284 Query: 338 EIQRKIQKELDTVIGRERRPRLSDRPQ-LPYLEAFILETFRHSSFLPFTIPHSTTRDTTL 396 E R +++E+ + RL +R + P ++ + ET R ++ I T+D + Sbjct: 285 EALRAVREEIQ----GGKHLRLEERQKNTPVFDSVLWETLRLTAAA--LITRDVTQDKKI 338 Query: 397 -----NGFYIPKKCCVFVNQW-QVNHDPELWEDPSEFRPERFLTADGTAINKPLSE---- 446 +++ + + V + DP++ + P F+ +RFL AD T Sbjct: 339 CLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARV 398 Query: 447 --KMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG---VKVDLTPIYGL-TMK 500 + +G C G A I + +L + + + V + YG ++ Sbjct: 399 KYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQ 458 Query: 501 HARCEHVQARLRF 513 A ++ R+RF Sbjct: 459 PAGDLEIRYRIRF 471 >2IJ7-A nrPDB Length = 396 Score = 106 bits (265), Expect = 2e-23, Method: Composition-based stats. Identities = 38/209 (18%), Positives = 78/209 (37%), Gaps = 32/209 (15%) Query: 284 TGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKI 343 TG + + S+ + + + E + FGAG + + ++ +L+ L+ +P+++ + Sbjct: 200 TGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLL 259 Query: 344 QKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPK 403 + + + A + E R + +P T D + + K Sbjct: 260 HE------------------KPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRK 301 Query: 404 KCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVL 463 V V N DPE + +P +R P + FG G+ C G L Sbjct: 302 GELVLVLLEGANFDPEHFPNPGSIELDR-----------PNPTSHLAFGRGQHFCPGSAL 350 Query: 464 AKWEIFLFLAILLQQL---EFSVPPGVKV 489 + + + LL+++ + +VP V Sbjct: 351 GRRHAQIGIEALLKKMPGVDLAVPIDQLV 379 >5HIW-A nrPDB Length = 398 Score = 105 bits (263), Expect = 3e-23, Method: Composition-based stats. Identities = 66/394 (16%), Positives = 130/394 (32%), Gaps = 75/394 (19%) Query: 86 LVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALN 145 +VL D + A++R + F R T T G RRL L Sbjct: 41 VVLRGADVV--AVLRDSETFSTR----TYDTGIM--KGALVTLGGEAHTRMRRLFNAVL- 91 Query: 146 TFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCF 205 S Y E V+ A+ ++ RL + ++ +S+ + + F Sbjct: 92 -------SPRVISRYEEATVTPVARRVVERL----VRKERAELFDDFAISMPMGVTSALF 140 Query: 206 GQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQ 265 G E E +L++ V ++ P + ++ + L+ Sbjct: 141 GLP-EERIAENDALIRKMIRSV-------------VMPQDPV-VVAEGRSAHAAMEAQLR 185 Query: 266 KTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTA 325 + + L + A G L E +V + ++T + Sbjct: 186 EIAEREVAHPS--------DTLLGEIARAIVAEG-LGGVEACEGVVLTLILGSYETTSWM 236 Query: 326 ISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFT 385 ++ L+ L+ P+ ++++ Q L I E+ R S Sbjct: 237 LANLLVALLAHPDAMNQLRQ------------------QPSLLPQAIEESTRWCSSAA-G 277 Query: 386 IPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLS 445 I R+ T+ G + ++++ ++D E++ P F R Sbjct: 278 IVRFVEREATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDIHR------------RP 325 Query: 446 EKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479 M+ FG G C+G LA+ E + +++LL++ Sbjct: 326 VGMLNFGGGLHYCVGAPLARMEARVGVSLLLERF 359 >2QBO-A nrPDB Length = 421 Score = 105 bits (261), Expect = 6e-23, Method: Composition-based stats. Identities = 49/281 (17%), Positives = 91/281 (32%), Gaps = 58/281 (20%) Query: 226 FVETASSGNPLDFFPILRYLPNPALQRFK----------------AFNQRFLWFLQKTVQ 269 F E + P+ F +L LP + K + +L ++ Sbjct: 151 FTEDYAEPFPIRIFMLLAGLPEEDIPHLKYLTDQMTRPDGSMTFAEAKEALYDYLIPIIE 210 Query: 270 EHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWS 329 + Q D + + +G I ++ + + G DTV +S+S Sbjct: 211 QRRQ----KPGTDAISIV-----ANGQVNGRPITSDEAKRMCGLLLVVGLDTVVNFLSFS 261 Query: 330 LMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHS 389 + +L PE ++++ + + + A E R S + Sbjct: 262 MEFLAKSPEHRQELIERPERI------------------PAACEELLRRFSLVADG--RI 301 Query: 390 TTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMM 449 T D +G + K + + Q D P R Sbjct: 302 LTSDYEFHGVQLKKGDQILLPQMLSGLDERENACPMHVDFSR------------QKVSHT 349 Query: 450 LFGMGKRRCIGEVLAKWEIFLFLAILLQQL-EFSVPPGVKV 489 FG G C+G+ LA+ EI + L L ++ +FS+ PG ++ Sbjct: 350 TFGHGSHLCLGQHLARREIIVTLKEWLTRIPDFSIAPGAQI 390 >5KYO-A nrPDB Length = 430 Score = 104 bits (259), Expect = 9e-23, Method: Composition-based stats. Identities = 69/408 (16%), Positives = 129/408 (31%), Gaps = 66/408 (16%) Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRR-LAQNALNTFSIASDPASSS 157 V +G DF L ++ +G W A R LA+ ++ F + S+ Sbjct: 53 VPEGLDFHQSWREIMRQAP---HPLMWTPHNGGHWVALRSDLAETVMSDF----ERFSNH 105 Query: 158 SCYLEEHVSKEAKALI---------SRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQH 208 + + + + EA LI + L+ P + V ++ ++ G Sbjct: 106 TVLVPKETAGEAYRLIPLSLDPPEHRPFRSLLNENLGPKPLRPIEQVVTDLAVSLIEGFR 165 Query: 209 FPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYL------PNPALQRFKAFNQRFLW 262 + + + P++ P L++L P+ ++ ++F Sbjct: 166 PKGRCNFTHEFAEQLPVRIFMRIVDLPVEDLPKLKHLADQYTRPDGSIP-LDDVTKQFRE 224 Query: 263 FLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 322 +L+ ++ D+ + G + + N+ + G DTV Sbjct: 225 YLRPVIEARR----IKPGEDMISRMI-----NGEVGGRPLTDIEAENICIQVLVGGLDTV 275 Query: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 382 + ++ +L ++R I + P L D L E FR + Sbjct: 276 VNMLGFTFSHLAKDHALRRAIAAD----------PSLIDDALL--------EFFRRFPVV 317 Query: 383 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 442 RD G + V V D EDP EFR R Sbjct: 318 SSA--REVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDPLEFRLGR----------- 364 Query: 443 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL-EFSVPPGVKV 489 + + FG G C G LA+ E+ + L ++ EF + + Sbjct: 365 -KARQHSTFGKGSHTCPGAHLARMEMKVVLREWFARIPEFRIEDDAPL 411 >5OMS-A nrPDB Length = 409 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 60/440 (13%), Positives = 124/440 (28%), Gaps = 76/440 (17%) Query: 54 VLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYT 113 + L +NP+ R+ + + A V + PD Sbjct: 19 MTQLERNPYEVYERLRAE---------APLAFVPVLGSYVASTAEVCREVATS--PDFEA 67 Query: 114 STLITDGQSL---TFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAK 170 G++ +G + A R + + AL + ++++ V A+ Sbjct: 68 VITPAGGRTFGHPAIIGVNGDIHADLRSMVEPAL--------QPAEVDRWIDDLVRPIAR 119 Query: 171 ALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETA 230 + R + G VSV ++ + + + E + + + Sbjct: 120 RYLERFEN--DGHAELVAQYCEPVSVRSLGDLLGLQEVDSDKLREWFAKLNRSFTNAAVD 177 Query: 231 SSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKH 290 +G + P + + + + D + H Sbjct: 178 ENGEFAN--------P-EGFAEGDQAKAEIRAVVDPLIDKWIEHPD--------DSAISH 220 Query: 291 SKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTV 350 G +E I + ++ +L+ L ++PE ++ + Sbjct: 221 WLHDGMPPGQTRDREYIYPTIYVYLLGAMQEPGHGMASTLVGLFSRPEQLEEVVDDP--- 277 Query: 351 IGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVN 410 + I E R +S + +T+ T+ G +P V ++ Sbjct: 278 ---------------TLIPRAIAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTPVMLS 322 Query: 411 QWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFL 470 NHD +E PS++ R + FG G C G A + + Sbjct: 323 YGSANHDTGKYEAPSQYDLHR------------PPLPHLAFGAGNHACAGIYFANHVMRI 370 Query: 471 FLAILLQQLEFSVPPGVKVD 490 L L F P ++ D Sbjct: 371 ALEEL-----FEAIPNLERD 385 >3BUJ-A nrPDB Length = 397 Score = 102 bits (255), Expect = 3e-22, Method: Composition-based stats. Identities = 43/269 (15%), Positives = 84/269 (31%), Gaps = 44/269 (16%) Query: 212 SSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEH 271 +L + + V+ + L L LP +++ L + Sbjct: 115 DDLLRPALARGAMDVVDELAYPLALRAVLGLLGLPAADWGAVGRWSRDVGRTLDRGASAE 174 Query: 272 YQDFDKNSVRDITGALFKHSKKGPRASGN-------------LIPQEKIVNLVNDIFGAG 318 ++ + + + + R G L+ + +IV+ V G Sbjct: 175 DMRRGHAAIAEFADYVERALARRRREGGEDLLALMLDAHDRGLMSRNEIVSTVVTFIFTG 234 Query: 319 FDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRH 378 +TV + + +++ L+ P+ +++ D L + E R+ Sbjct: 235 HETVASQVGNAVLSLLAHPDQLDLLRRRPD------------------LLAQAVEECLRY 276 Query: 379 SSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGT 438 + D L G + + V V N DP ++ P +F ER Sbjct: 277 DPSVQSN-TRQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDFDIERD------ 329 Query: 439 AINKPLSEKMMLFGMGKRRCIGEVLAKWE 467 M FG G R C+G LA+ + Sbjct: 330 ------PVPSMSFGAGMRYCLGSYLARTQ 352 >3NV6-A nrPDB Length = 452 Score = 94.4 bits (233), Expect = 1e-19, Method: Composition-based stats. Identities = 56/349 (16%), Positives = 106/349 (30%), Gaps = 66/349 (18%) Query: 148 SIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQ 207 ++ + +E+ V + A +LI + V V Sbjct: 150 ALDKGLNLAKIRKVEDKVREVASSLIDSFAARGECDFAAEYAELFPVHV----------- 198 Query: 208 HFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKT 267 ++L E + S P P +A N F ++ Sbjct: 199 --------FMALADLPLEDIPVLSEYARQMTRPE-GNTPEEMATDLEAGNNGFYAYVDPI 249 Query: 268 VQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAIS 327 ++ D+ + +G I +K L++ + G DTV +S Sbjct: 250 IRARV----GGDGDDLITLMV-----NSEINGERIAHDKAQGLISLLLLGGLDTVVNFLS 300 Query: 328 WSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIP 387 + +++L PE+ +++ + ++ E FR + Sbjct: 301 FFMIHLARHPELVAELRSDPLKLMRG------------------AEEMFRRFPVVSEA-- 340 Query: 388 HSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEK 447 +D G ++ + + + D +P + R S Sbjct: 341 RMVAKDQEYKGVFLKRGDMILLPTALHGLDDAANPEPWKLDFSR------------RSIS 388 Query: 448 MMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL-EFSVPPGVKVDLTPIY 495 FG G RC G LA+ E+ + L L+++ EFS G TPIY Sbjct: 389 HSTFGGGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGE----TPIY 433 >4C9K-A nrPDB Length = 421 Score = 92.5 bits (228), Expect = 4e-19, Method: Composition-based stats. Identities = 55/381 (14%), Positives = 111/381 (29%), Gaps = 71/381 (18%) Query: 99 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158 R + F R ++ + + + P R+ LN I Sbjct: 77 YRSPERFSSR-VIWVPREAGEAYDMVPTKLDPPEHTPYRKAIDKGLNLAEIRK------- 128 Query: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218 LE+ + A +I + + V V + + ++ Sbjct: 129 --LEDQIRTIAVEIIEGFADRGHCEFGSEFSTVFPVRVFLALAGLPV--------EDATK 178 Query: 219 LVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKN 278 L +E + + P + +A N+ F ++ + Sbjct: 179 LGLLANEMTRPSGNT------------PEEQGRSLEAANKGFFEYVAPIIAARR----GG 222 Query: 279 SVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPE 338 S D+ + G +P ++ + LV+ + G DTV + + ++YL PE Sbjct: 223 SGTDLITRIL-----NVEIDGKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSRHPE 277 Query: 339 IQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNG 398 ++++E L+ + E FR + + D +G Sbjct: 278 TVAEMRREPLK------------------LQRGVEELFRRFAVVSDA--RYVVSDMEFHG 317 Query: 399 FYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRC 458 + + + + D +DP R F G RC Sbjct: 318 TMLKEGDLILLPTALHGLDDRHHDDPMTVDLSR------------RDVTHSTFAQGPHRC 365 Query: 459 IGEVLAKWEIFLFLAILLQQL 479 G LA+ E+ + L L ++ Sbjct: 366 AGMHLARLEVTVMLQEWLARI 386 >2RCM-A nrPDB Length = 495 Score = 77.1 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 65/495 (13%), Positives = 151/495 (30%), Gaps = 68/495 (13%) Query: 43 PEPWGWPLLGHV-----LTLGKNPHLALSRMSQRYGD-VLQIRI--------GSTPVLVL 88 P +G P++G + + ++Y V ++ + V +L Sbjct: 31 PGNYGLPIVGPIKDRWDYFYDQGAEEFFKSRIRKYNSTVYRVNMPPGAFIAENPQVVALL 90 Query: 89 SRLDTIRQALVRQGD--DFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNT 146 V + + D + ++ L + L++ S P Sbjct: 91 DGKSFPVLFDVDKVEKKDLLTGTYMPSTELTGGYRILSYLDPSEPKHEK----------L 140 Query: 147 FSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFG 206 ++ SS + L L++ ++ G D + N + +G Sbjct: 141 KNLLFFLLKSSRNRIFPEFQATYSELFDSLEKELSLKGKADFGGSSDGTAFNFLARAFYG 200 Query: 207 QH----FPESSDEMLSLVKNTHEFVETASSGNPLDFF-PILRYLPNPALQRFKAFNQRFL 261 + ++ L S G P P++ P + + + Sbjct: 201 TNPADTKLKADAPGLITKWVLFNLHPLLSIGLPRVIEEPLIHTFSLPPALVKSDYQRLYE 260 Query: 262 WFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDT 321 +FL+ + + R+ + G I N+V I AG Sbjct: 261 FFLESAGEILVEADKLGISREEATHNLLFATCFNTWGGMKIL---FPNMVKRIGRAGH-- 315 Query: 322 VTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRP-RLSDRPQLPYLEAFILETFRHSS 380 ++ ++ +E+ +VI + ++ ++ + E R Sbjct: 316 ----------------QVHNRLAEEIRSVIKSNGGELTMGAIEKMELTKSVVYECLRFEP 359 Query: 381 FLPFTIPHSTTRDTTLNG----FYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTAD 436 + +D + F + ++ Q DP++++ EF PERF+ + Sbjct: 360 PVTAQYGR-AKKDLVIESHDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEE 418 Query: 437 GTAINKPLSEKMMLF----GMGKRRCIGEVLAKWEIFLFLAILLQQLE-FSV-----PPG 486 G + + + +G ++C G+ LF+ + ++ + F + P G Sbjct: 419 GEKLLRHVLWSNGPETETPTVGNKQCAGKDFVVLVARLFVIEIFRRYDSFDIEVGTSPLG 478 Query: 487 VKVDLTPIYGLTMKH 501 V+ + + + H Sbjct: 479 SSVNFSSLRKASFHH 493 >3DBM-A nrPDB Length = 473 Score = 77.1 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 73/472 (15%), Positives = 147/472 (31%), Gaps = 69/472 (14%) Query: 43 PEPWGWPLLGHV-----LTLGKNP-HLALSRMSQRY-GDVLQIRIGSTP-------VLVL 88 P +G P + G Q+Y V + + P V+VL Sbjct: 12 PGSYGIPFFQPIKDRLEYFYGTGGRDEYFRSRMQKYQSTVFRANMPPGPFVSSNPKVIVL 71 Query: 89 SRLDTIRQAL----VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNAL 144 + V + D F G + ++ L + L++ S P A + L Sbjct: 72 LDAKSFPILFDVSKVEKKDLFTGTY-MPSTKLTGGYRVLSYLDPSEPRHAQLKNLL---- 126 Query: 145 NTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMC 204 F + + ++ E ++ L L+ +A G + + +G Sbjct: 127 --FFMLKNSSNRVIPQFETTYTE----LFEGLEAELAKNGKAAFNDVGEQAAFRFLGRAY 180 Query: 205 FGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFL 264 F + PE + S +V + P P R AF + Sbjct: 181 FNSN-PEETKLGTSAPTLISSWVLFNLAPTLDLGLPWFLQEPLLHTFRLPAF------LI 233 Query: 265 QKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV-T 323 + T + Y F + + + ++K + I+ V G + Sbjct: 234 KSTYNKLYDYFQS-----VATPVMEQAEKLGVPKDEAV--HNILFAVCFNTFGGVKILFP 286 Query: 324 TAISWSLMYLVTKPEIQRKIQKELDTVIGR--ERRPRLSDRPQLPYLEAFILETFRHSSF 381 + W + Q + +E+ I + L Q+P ++ + E+ R Sbjct: 287 NTLKWIGLA-GENLHTQ--LAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVVYESLRIEPP 343 Query: 382 LPFTIPHSTTRDTTLNG----FYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADG 437 +P + T+ F + K +F Q DP++++ P E+ P+RF+ Sbjct: 344 VPPQYG-KAKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRFVGDGE 402 Query: 438 TAINKPLSEKMMLFGMGK---------RRCIGEVLAKWEIFLFLAILLQQLE 480 + + + G ++C G+ LF+ L ++ + Sbjct: 403 ALLK------YVWWSNGPETESPTVENKQCAGKDFVVLITRLFVIELFRRYD 448 >2YJN-B nrPDB Length = 381 Score = 57.5 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 18/133 (13%), Positives = 41/133 (30%), Gaps = 19/133 (14%) Query: 315 FGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILE 374 AG + + +++ + +P + +I + + + E Sbjct: 220 LFAGAEMTANTVVDAVLAVSAEPGLAERIADDPAA------------------AQRTVAE 261 Query: 375 TFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLT 434 R L + T + L I + V V N DPE++ +P +R Sbjct: 262 VLRLHPAL-HLERRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVDRPDA 320 Query: 435 ADGTAINKPLSEK 447 + ++ + Sbjct: 321 DRALSAHRGHPGR 333 >5L9W-B nrPDB Length = 732 Score = 32.0 bits (71), Expect = 0.64, Method: Composition-based stats. Identities = 14/97 (14%), Positives = 35/97 (36%), Gaps = 4/97 (4%) Query: 257 NQRFLWFLQKTVQEHYQDFDKNSVRDITG-ALFKHSKKGPRASGN---LIPQEKIVNLVN 312 + W + V E +N + L ++ +SG+ + +E + + Sbjct: 107 GRGAQWTDGQRVAERRNIAVQNKPLPLIERDLILGVRERIDSSGSVVRPLDEEDVRTKLR 166 Query: 313 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDT 349 + G + ++ WS M + ++ I++E Sbjct: 167 MLMDRGARAIVVSLLWSFMNPAHEKRVREIIREEYKE 203 >4YXC-B nrPDB Length = 227 Score = 31.7 bits (70), Expect = 0.86, Method: Composition-based stats. Identities = 10/48 (20%), Positives = 16/48 (33%), Gaps = 2/48 (4%) Query: 364 QLPYLEAFILETFRHSSFLPFTIPHSTTR--DTTLNGFYIPKKCCVFV 409 +L I E R + + D +NG+ I + V V Sbjct: 157 ELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVV 204 >4YXB-D nrPDB Length = 80 Score = 31.3 bits (69), Expect = 0.94, Method: Composition-based stats. Identities = 10/48 (20%), Positives = 16/48 (33%), Gaps = 2/48 (4%) Query: 364 QLPYLEAFILETFRHSSFLPFTIPHSTTR--DTTLNGFYIPKKCCVFV 409 +L I E R + + D +NG+ I + V V Sbjct: 10 ELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVV 57 >5U4N-A nrPDB Length = 362 Score = 30.1 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 11/41 (26%), Positives = 21/41 (51%), Gaps = 5/41 (12%) Query: 422 EDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEV 462 E+PS+F P ++L A+ + ++ + FG C G+ Sbjct: 302 ENPSDFDPRKYLGKTIEAMKQICLDRYLAFG-----CEGQA 337 >5U1D-B nrPDB Length = 686 Score = 29.0 bits (63), Expect = 6.0, Method: Composition-based stats. Identities = 22/76 (28%), Positives = 34/76 (44%), Gaps = 2/76 (2%) Query: 323 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 382 +SWSL +++ P Q K Q +++ + R +LS RP LP L A + Sbjct: 108 AAGLSWSLWAVLSPPGAQEKEQDQVNNKVLMWRLLKLS-RPDLPLLVAAFF-FLVLAVLG 165 Query: 383 PFTIPHSTTRDTTLNG 398 IPH + R + G Sbjct: 166 ETLIPHYSGRVIDILG 181 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.126 0.328 Lambda K H 0.267 0.0389 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,933,137 Number of Sequences: 36641 Number of extensions: 704513 Number of successful extensions: 2940 Number of sequences better than 10.0: 179 Number of HSP's better than 10.0 without gapping: 248 Number of HSP's successfully gapped in prelim test: 79 Number of HSP's that attempted gapping in prelim test: 1977 Number of HSP's gapped (non-prelim): 359 length of query: 516 length of database: 10,336,785 effective HSP length: 101 effective length of query: 415 effective length of database: 6,636,044 effective search space: 2753958260 effective search space used: 2753958260 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 61 (28.2 bits)