BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P05154 (406 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2OL2-A nrPDB 763 0.0 3DY0-A nrPDB 691 0.0 6EE5-A nrPDB 359 1e-99 6HGE-B nrPDB 348 2e-96 6F02-A nrPDB 327 4e-90 3NE4-A nrPDB 324 4e-89 5HGC-A nrPDB 317 5e-87 1YXA-A nrPDB 312 2e-85 2VDY-A nrPDB 312 2e-85 6F4U-A nrPDB 303 1e-82 1QMB-A nrPDB 301 4e-82 4Y40-A nrPDB 284 5e-77 2XN5-A nrPDB 282 2e-76 2V95-A nrPDB 263 1e-70 1BY7-A nrPDB 195 3e-50 4AJT-A nrPDB 189 3e-48 4AJU-A nrPDB 188 4e-48 2H4Q-A nrPDB 187 8e-48 2H4P-A nrPDB 182 2e-46 4ZK0-A nrPDB 179 1e-45 3NDA-A nrPDB 178 4e-45 5INW-A nrPDB 177 6e-45 1UHG-A nrPDB 176 2e-44 4EB1-I nrPDB 170 1e-42 1HLE-A nrPDB 169 2e-42 4GA7-A nrPDB 169 2e-42 1ATT-A nrPDB 168 4e-42 3LW2-A nrPDB 167 6e-42 1C5G-A nrPDB 164 7e-41 3F02-A nrPDB 163 1e-40 1JMJ-A nrPDB 161 4e-40 3ZHA-A nrPDB 159 2e-39 4DY0-A nrPDB 149 2e-36 4KDS-A nrPDB 149 3e-36 4P0F-A nrPDB 147 8e-36 5NCS-A nrPDB 139 2e-33 1XQJ-A nrPDB 137 7e-33 1IMV-A nrPDB 137 7e-33 4DTE-A nrPDB 135 4e-32 1C8O-A nrPDB 134 8e-32 5NCU-A nrPDB 133 2e-31 2R9Y-A nrPDB 126 2e-29 6CJ7-A nrPDB 126 2e-29 1JJO-C nrPDB 125 4e-29 3LE2-A nrPDB 123 1e-28 2PEF-A nrPDB 123 1e-28 3PZF-A nrPDB 122 2e-28 1SEK-A nrPDB 117 7e-27 2OAY-A nrPDB 114 5e-26 1M93-B nrPDB 112 3e-25 3OZQ-A nrPDB 111 6e-25 3STO-A nrPDB 111 6e-25 1K9O-I nrPDB 111 7e-25 1SNG-A nrPDB 97 2e-20 6BJ5-B nrPDB 96 3e-20 1MTP-A nrPDB 94 7e-20 5M3Y-A nrPDB 80 2e-15 2WXZ-C nrPDB 79 3e-15 2WXX-A nrPDB 78 6e-15 5C98-A nrPDB 62 6e-10 4B5T-A nrPDB 30 1.8 2V5J-A nrPDB 30 1.9 5LQD-A nrPDB 29 3.1 4W8Y-A nrPDB 28 4.9 4QP0-A nrPDB 28 9.1 2AGK-A nrPDB 28 9.4 >2OL2-A nrPDB Length = 395 Score = 763 bits (1971), Expect = 0.0, Method: Compositional matrix adjust. Identities = 372/376 (98%), Positives = 374/376 (99%), Gaps = 1/376 (0%) Query: 32 EDLH-VGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQ 90 +D H VGATVAPSSRRDFTFDLYRALASAAPSQ+IFFSPVSISMSLAMLSLGAGSSTKMQ Sbjct: 20 DDKHMVGATVAPSSRRDFTFDLYRALASAAPSQNIFFSPVSISMSLAMLSLGAGSSTKMQ 79 Query: 91 ILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMK 150 ILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMK Sbjct: 80 ILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMK 139 Query: 151 TLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWE 210 TLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWE Sbjct: 140 TLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWE 199 Query: 211 TSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILP 270 TSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILP Sbjct: 200 TSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILP 259 Query: 271 SEGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSH 330 SEGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSH Sbjct: 260 SEGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSH 319 Query: 331 ADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLM 390 ADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLM Sbjct: 320 ADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLM 379 Query: 391 FIVDNNILFLGKVNRP 406 FIVDNNILFLGKVNRP Sbjct: 380 FIVDNNILFLGKVNRP 395 >3DY0-A nrPDB Length = 336 Score = 691 bits (1783), Expect = 0.0, Method: Compositional matrix adjust. Identities = 335/336 (99%), Positives = 336/336 (100%) Query: 37 GATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLG 96 GATVAPSSRRDFTFDLYRALASAAPSQ+IFFSPVSISMSLAMLSLGAGSSTKMQILEGLG Sbjct: 1 GATVAPSSRRDFTFDLYRALASAAPSQNIFFSPVSISMSLAMLSLGAGSSTKMQILEGLG 60 Query: 97 LNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLAD 156 LNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLAD Sbjct: 61 LNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLAD 120 Query: 157 TFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHK 216 TFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHK Sbjct: 121 TFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHK 180 Query: 217 GTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQ 276 GTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQ Sbjct: 181 GTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQ 240 Query: 277 QVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGI 336 QVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGI Sbjct: 241 QVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGI 300 Query: 337 SNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTF 372 SNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTF Sbjct: 301 SNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTF 336 >6EE5-A nrPDB Length = 379 Score = 359 bits (922), Expect = 1e-99, Method: Compositional matrix adjust. Identities = 190/368 (51%), Positives = 254/368 (69%), Gaps = 17/368 (4%) Query: 44 SRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSS 103 + DF F LYR LA ++P ++IFFSPVSIS +LAMLSLGA T QILEGLG N S Sbjct: 24 ANTDFAFSLYRELAKSSPDKNIFFSPVSISSALAMLSLGAKGDTHTQILEGLGFN----S 79 Query: 104 EKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFR 163 E ++H+GFQ LLQ LN+P+ G QL N LF D + L D+F+ K LY A+ F +F Sbjct: 80 EADIHQGFQHLLQTLNRPK-GLQLKTANGLFVDKSLKLLDSFLEDSKKLYQAEAFSVDF- 137 Query: 164 DSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDF 223 D A KQIND+V KQT GKI DLLK+LDS+ V+++VN I+FK KW+ F+ + T+E+DF Sbjct: 138 DPEEAKKQINDWVEKQTNGKIKDLLKDLDSDTVLVLVNAIYFKGKWKKPFDPENTKEEDF 197 Query: 224 YVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLS 283 +V +T V+VPMMS++ +++Y D LSC+V+ +PY+GNA+ L ILP EG +Q +E L+ Sbjct: 198 HVDEKTTVKVPMMSQKGKFYYYHDDELSCKVLELPYKGNASMLIILPDEGGLQHLEQSLT 257 Query: 284 EKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQ 343 +TL KWLK +R +ELYLPKF IEG+Y L++VL +LGI+++F+ ADLSGI+ + Sbjct: 258 PETLSKWLKSLTRRSVELYLPKFKIEGTYDLKEVLSNLGITDLFSPGADLSGIT-EEKLY 316 Query: 344 VSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVF--NRPFLMFIVDN---NIL 398 VS+ VHKAV+EV+E GT AAAA TF A S F +RPFL I +N +IL Sbjct: 317 VSKAVHKAVLEVNEEGTEAAAA-----TFLEAIPMSIPPEFKADRPFLFLIRENKTGSIL 371 Query: 399 FLGKVNRP 406 F+GKV P Sbjct: 372 FMGKVVNP 379 >6HGE-B nrPDB Length = 409 Score = 348 bits (894), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 188/381 (49%), Positives = 251/381 (65%), Gaps = 13/381 (3%) Query: 35 HVGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEG 94 HV +A S+ DF F LY+ L AP +++ FSP+SIS +LA LSLGA ++T +IL+G Sbjct: 30 HVDRGLA-SANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKG 88 Query: 95 LGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYL 154 L NL ++SE E+H+ FQ LL+ LNQ D QLS+GNA+F + L D F K LY Sbjct: 89 LKFNLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYG 148 Query: 155 ADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFN 214 ++ F T+F+DSA A K INDYV T+GKI DL+K+LDS ++++VNYIFFKAKWE F+ Sbjct: 149 SEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKWEMPFD 208 Query: 215 HKGTQEQDFYVTSETVVRVPMMSREDQYH----YLLDRNLSCRVVGVPYQGNATALFILP 270 + T + FY++ + V VPMMS +H Y D LSC VV + Y GNA+ALFILP Sbjct: 209 PQDTHQSRFYLSKKKWVMVPMMSL---HHLTIPYFRDEELSCTVVQLNYTGNASALFILP 265 Query: 271 SEGKMQQVENGLSEKTLRKWLKMFKKRQL-ELYLPKFSIEGSYQLEKVLPSLGISNVFTS 329 + KM++VE LS +TL +W + R++ ELYLPKFSI Y L +L LGI FTS Sbjct: 266 DQDKMEEVEAMLSRETLNRWGDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTS 325 Query: 330 HADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLV-FNRPF 388 ADLSGI+ N+ VS++VHKAV++V E GT A+AAT T SA + ++ +V FNRPF Sbjct: 326 KADLSGITGARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRFNRPF 385 Query: 389 LMFIVDN---NILFLGKVNRP 406 LM IVD+ +I F+ KV P Sbjct: 386 LMIIVDHFTWSIFFMSKVTNP 406 >6F02-A nrPDB Length = 389 Score = 327 bits (839), Expect = 4e-90, Method: Compositional matrix adjust. Identities = 177/375 (47%), Positives = 249/375 (66%), Gaps = 9/375 (2%) Query: 40 VAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNL 99 +AP++ DF F Y +AS P ++IFFSP+SIS + AMLSLGA S ++ QILEGLG NL Sbjct: 7 IAPANA-DFAFRFYYLIASETPGKNIFFSPLSISAAYAMLSLGACSHSRSQILEGLGFNL 65 Query: 100 QKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFP 159 + SE ++HRGFQ LL LN P G + +G+ALF + F++ +Y A F Sbjct: 66 TELSESDVHRGFQHLLHTLNLPGHGLETRVGSALFLSHNLKFLAKFLNDTMAVYEAKLFH 125 Query: 160 TNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQ 219 TNF D+ G ++ IND+V K+T+GKIVDL+ L + ++++VNYI+FKA WE F T Sbjct: 126 TNFYDTVGTIQLINDHVKKETRGKIVDLVSELKKDVLMVLVNYIYFKALWEKPFISSRTT 185 Query: 220 EQDFYVTSETVVRVPMMSREDQYH-YLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQV 278 +DFYV T VRVPMM ++ ++H YL DR L C V+ + Y+G+AT FILP++GKM+++ Sbjct: 186 PKDFYVDENTTVRVPMMLQDQEHHWYLHDRYLPCSVLRMDYKGDATVFFILPNQGKMREI 245 Query: 279 ENGLSEKTLRKWLKMFKKR----QLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLS 334 E L+ + L +W + +KR +LEL+LPKFSI GSY L+++LP LG +++F+ ADLS Sbjct: 246 EEVLTPEMLMRWNNLLRKRNFYKKLELHLPKFSISGSYVLDQILPRLGFTDLFSKWADLS 305 Query: 335 GISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVD 394 GI+ ++ S+ HKA ++VDE+GT AAAAT F SA+ N L FNRPFL+ I Sbjct: 306 GITKQQKLEASKSFHKATLDVDEAGTEAAAATSFAIKFFSAQTNRHILRFNRPFLVVIFS 365 Query: 395 N---NILFLGKVNRP 406 ++LFLGKV P Sbjct: 366 TSTQSVLFLGKVVDP 380 >3NE4-A nrPDB Length = 424 Score = 324 bits (831), Expect = 4e-89, Method: Compositional matrix adjust. Identities = 180/412 (43%), Positives = 249/412 (60%), Gaps = 22/412 (5%) Query: 6 LLCLVLLS----PQGASLHR----HHPREMKKRVEDLHVGATVAPSSRRDFTFDLYRALA 57 L CLV +S PQG + + HH ++ H + +F F LYR LA Sbjct: 21 LCCLVPVSLAEDPQGDAAQKTDTSHHDQD--------HPTFNKITPNLAEFAFSLYRQLA 72 Query: 58 SAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLLQE 117 + S +IFFSPVSI+ + AMLSLG + T +ILEGL NL + E ++H GFQ+LL+ Sbjct: 73 HQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRT 132 Query: 118 LNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVA 177 LNQP QL+ GN LF + L D F+ +K LY ++ F NF D+ A KQINDYV Sbjct: 133 LNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVE 192 Query: 178 KQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMS 237 K T+GKIVDL+K LD + V +VNYIFFK KWE F K T+E+DF+V T V+VPMM Sbjct: 193 KGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMK 252 Query: 238 REDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLSEKTLRKWLKMFKKR 297 R ++ + LS V+ + Y GNATA+F LP EGK+Q +EN L+ + K+L+ +R Sbjct: 253 RLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRR 312 Query: 298 QLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDE 357 L+LPK SI G+Y L+ VL LGI+ VF++ ADLSG++ + +++S+ VHKAV+ +DE Sbjct: 313 SASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDE 372 Query: 358 SGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNNI---LFLGKVNRP 406 GT AA G +F + FN+PF+ +++ N LF+GKV P Sbjct: 373 KGTEAA---GAMFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNP 421 >5HGC-A nrPDB Length = 380 Score = 317 bits (813), Expect = 5e-87, Method: Compositional matrix adjust. Identities = 160/363 (44%), Positives = 236/363 (65%), Gaps = 6/363 (1%) Query: 47 DFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKE 106 DF F +R + AP+++IF+SPVSIS + AML+LGA S+T+ QILEGL NL + EKE Sbjct: 17 DFAFQFFREVTQEAPNKNIFYSPVSISTAFAMLALGARSATQSQILEGLAFNLTEIQEKE 76 Query: 107 LHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSA 166 +H GF L+ LN P G QL++ NA+F + L F+ K LY + F T+F Sbjct: 77 IHEGFHNLIHMLNHPEGGVQLNMMNAIFVTAALALLRKFLDDAKALYQLEAFTTDFNKPT 136 Query: 167 GAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVT 226 A KQINDY+ ++T GKI +L+K++D V+++ ++++FK WE F + T+E++F+V Sbjct: 137 EAEKQINDYIERKTHGKITNLVKDMDPQTVMLLASFVYFKGSWEKPFEAEHTEEREFFVD 196 Query: 227 SETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLSEKT 286 +ET V+VPMM + ++ + D LSC VV + Y G+ATA +LP++GKM+Q+E L ++T Sbjct: 197 AETTVKVPMMYQMGRFDFYFDEELSCTVVRLHYNGSATAFLVLPAKGKMKQLEQTLDKET 256 Query: 287 LRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSE 346 ++KW +R + LY PKFSI GSY++ L +GI +VFT+ ADLSGI+ +++VS+ Sbjct: 257 IQKWSDHLFQRFMNLYFPKFSISGSYEISNTLRKMGIVDVFTNQADLSGITGSPDLKVSK 316 Query: 347 MVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVD---NNILFLGKV 403 +VHKA ++VDE GT AAAAT S + F+ PFLM I D N+ LF+GK+ Sbjct: 317 VVHKASLDVDEKGTEAAAATAVEIMPISF---PPTIEFSHPFLMLIFDRDTNSTLFIGKI 373 Query: 404 NRP 406 P Sbjct: 374 VNP 376 >1YXA-A nrPDB Length = 398 Score = 312 bits (799), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 177/365 (48%), Positives = 234/365 (64%), Gaps = 5/365 (1%) Query: 47 DFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKE 106 DF F LY+ L P +I FSP+SIS +LA++SLGA +T +ILEGL NL ++SE + Sbjct: 33 DFAFSLYKELVLKNPDTNIVFSPLSISAALALVSLGAKGNTLEEILEGLKFNLTETSEAD 92 Query: 107 LHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSA 166 +H+GF LLQ LNQP+D Q+S G+ALF + + F KTLY A+ F +F+ Sbjct: 93 IHQGFGHLLQRLNQPKDQVQISTGSALFIEKRQQILTEFQEKAKTLYQAEAFTADFQQPR 152 Query: 167 GAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVT 226 A K INDYV KQT+G I +L+ +LD ++++VNYI+FKAKW+ F+ T + +FY Sbjct: 153 QAKKLINDYVRKQTQGMIKELVSDLDKRTLMVLVNYIYFKAKWKVPFDPLDTFKSEFYCG 212 Query: 227 SETVVRVPMMSRED-QYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLSEK 285 V VPMMS ED Y D LSC VV + Y GNA+ALFILP +G+MQQVE L + Sbjct: 213 KRRPVIVPMMSMEDLTTPYFRDEELSCTVVELKYTGNASALFILPDQGRMQQVEASLQPE 272 Query: 286 TLRKWLKMFKKRQL-ELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQV 344 TLRKW K R + EL+LPKFSI Y LE VL LGI VF++ ADLS I+ +++V Sbjct: 273 TLRKWKNSLKPRMIDELHLPKFSISTDYSLEDVLSKLGIREVFSTQADLSAITGTKDLRV 332 Query: 345 SEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNNI---LFLG 401 S++VHKAV++V E+GT AAAATG F SA+L + FNRPFL+ I D F+ Sbjct: 333 SQVVHKAVLDVAETGTEAAAATGVKFVPMSAKLYPLTVYFNRPFLIMIFDTETEIAPFIA 392 Query: 402 KVNRP 406 K+ P Sbjct: 393 KIANP 397 >2VDY-A nrPDB Length = 373 Score = 312 bits (799), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 159/367 (43%), Positives = 232/367 (63%), Gaps = 6/367 (1%) Query: 43 SSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKS 102 S+ DF F LY+ L + +P ++IF SPVSISM+LAMLSLG T+ Q+L+GLG NL + Sbjct: 9 SANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTER 68 Query: 103 SEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNF 162 SE E+H+GFQ L Q + ++++GNALF D ++L ++F + +K Y ++ NF Sbjct: 69 SETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNF 128 Query: 163 RDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQD 222 +D A A +QIN YV +T+GKIVDL LDS A++++VNYIFFK W F+ T+E++ Sbjct: 129 QDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREEN 188 Query: 223 FYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGL 282 FYV TVV+VPMM + YL D L C++V + Y GN T FILP +GKM V L Sbjct: 189 FYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAAL 248 Query: 283 SEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNI 342 S T+ +W Q++LY+PK +I G Y L VL +GI+++FT+ A+ S I+ + + Sbjct: 249 SRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTTQANFSRITQDAQL 308 Query: 343 QVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDN---NILF 399 + S++VHKAV++++E GT AA G +F R L FN+PF++ I D+ + LF Sbjct: 309 KSSKVVHKAVLQLNEEGTEAA---GAMFLEAIPRSKPIILRFNQPFIIMIFDHFTWSSLF 365 Query: 400 LGKVNRP 406 L +V P Sbjct: 366 LARVMNP 372 >6F4U-A nrPDB Length = 341 Score = 303 bits (775), Expect = 1e-82, Method: Compositional matrix adjust. Identities = 150/322 (46%), Positives = 217/322 (67%), Gaps = 6/322 (1%) Query: 40 VAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNL 99 +AP++ DF F Y +AS P ++IFFSP+SIS + AMLSLGA S ++ QILEGLG NL Sbjct: 5 IAPANA-DFAFRFYYLIASETPGKNIFFSPLSISAAYAMLSLGACSHSRSQILEGLGFNL 63 Query: 100 QKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFP 159 + SE ++HRGFQ LL LN P G + +G+ALF + F++ +Y A F Sbjct: 64 TELSESDVHRGFQHLLHTLNLPGHGLETRVGSALFLSHNLKFLAKFLNDTMAVYEAKLFH 123 Query: 160 TNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQ 219 TNF D+ G ++ IND+V K+T+GKIVDL+ L + ++++VNYI+FKA WE F T Sbjct: 124 TNFYDTVGTIQLINDHVKKETRGKIVDLVSELKKDVLMVLVNYIYFKALWEKPFISSRTT 183 Query: 220 EQDFYVTSETVVRVPMMSREDQYH-YLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQV 278 +DFYV T VRVPMM ++ ++H YL DR L C V+ + Y+G+AT FILP++GKM+++ Sbjct: 184 PKDFYVDENTTVRVPMMLQDQEHHWYLHDRYLPCSVLRMDYKGDATVFFILPNQGKMREI 243 Query: 279 ENGLSEKTLRKWLKMFKKR----QLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLS 334 E L+ + L +W + +KR +LEL+LPKFSI GSY L+++LP LG +++F+ ADLS Sbjct: 244 EEVLTPEMLMRWNNLLRKRNFYKKLELHLPKFSISGSYVLDQILPRLGFTDLFSKWADLS 303 Query: 335 GISNHSNIQVSEMVHKAVVEVD 356 GI+ ++ S+ HKA ++VD Sbjct: 304 GITKQQKLEASKSFHKATLDVD 325 >1QMB-A nrPDB Length = 326 Score = 301 bits (771), Expect = 4e-82, Method: Compositional matrix adjust. Identities = 157/319 (49%), Positives = 211/319 (66%), Gaps = 2/319 (0%) Query: 47 DFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKE 106 +F F LYR LA + S +IFFSPVSI+ + AMLSLG + T +ILEGL NL + E Sbjct: 8 EFAFSLYRQLAHQS-STNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAA 66 Query: 107 LHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSA 166 +H GFQ+LL+ LNQP QL+ GN LF + L D F+ +K LY ++ F NF D+ Sbjct: 67 IHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTE 126 Query: 167 GAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVT 226 A KQINDYV K T+GKIVDL+K LD + V +VNYIFFK KWE F K T+E+DF+V Sbjct: 127 EAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVD 186 Query: 227 SETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLSEKT 286 T V+VPMM R ++ + LS V+ + Y GNATA+F LP EGK+Q +EN L+ Sbjct: 187 QVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDI 246 Query: 287 LRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSE 346 + K+L+ +R L+LPK SI G+Y L+ VL LGI+ VF++ ADLSG++ + +++S+ Sbjct: 247 ITKFLEN-DRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSK 305 Query: 347 MVHKAVVEVDESGTRAAAA 365 VHKAV+ +DE GT AA A Sbjct: 306 AVHKAVLTIDEKGTEAAGA 324 >4Y40-A nrPDB Length = 414 Score = 284 bits (727), Expect = 5e-77, Method: Compositional matrix adjust. Identities = 143/364 (39%), Positives = 222/364 (60%), Gaps = 10/364 (2%) Query: 47 DFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKE 106 D F L + LA P ++IF SP+SIS + +ML LGA ST +I +G N +K EK+ Sbjct: 54 DLGFKLLKKLAFYNPGRNIFLSPLSISTAFSMLCLGAQDSTLDEIKQGF--NFRKMPEKD 111 Query: 107 LHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSA 166 LH GF ++ EL Q +LS+GN LF D + Q F+ K Y A+T TNF++ Sbjct: 112 LHEGFHYIIHELTQKTQDLKLSIGNTLFIDQRLQPQRKFLEDAKNFYSAETILTNFQNLE 171 Query: 167 GAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVT 226 A KQIND+++++T GKI +L++N+D V+++ NYIFF+A+W+ F+ T+E+DF++ Sbjct: 172 MAQKQINDFISQKTHGKINNLIENIDPGTVMLLANYIFFRARWKHEFDPNVTKEEDFFLE 231 Query: 227 SETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLSEKT 286 + V+VPMM R Y D LSC ++ +PYQ N TA+FILP EGK++ +E GL T Sbjct: 232 KNSSVKVPMMFRSGIYQVGYDDKLSCTILEIPYQKNITAIFILPDEGKLKHLEKGLQVDT 291 Query: 287 LRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSE 346 +W + +R + + +P+ + G++ L+K L +G+S +F H DL+ I+ H +++V E Sbjct: 292 FSRWKTLLSRRVVCVSVPRLHMTGTFDLKKTLSYIGVSKIFEEHGDLTKIAPHRSLKVGE 351 Query: 347 MVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLV-FNRPFLMFIVDNNI---LFLGK 402 VHKA +++DE GT AA TG ++ + + V ++P+L+ I I LFLGK Sbjct: 352 AVHKAELKMDERGTEGAAGTGA----QTLPMETPLCVKIDKPYLLLIYSEKIPSVLFLGK 407 Query: 403 VNRP 406 + P Sbjct: 408 IVNP 411 >2XN5-A nrPDB Length = 350 Score = 282 bits (721), Expect = 2e-76, Method: Compositional matrix adjust. Identities = 136/324 (41%), Positives = 208/324 (64%), Gaps = 1/324 (0%) Query: 43 SSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKS 102 S DF F+LYR P ++IFFSPVSIS +L MLS GA ST+ +I+E LG NL + Sbjct: 13 SINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDT 72 Query: 103 SEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNF 162 E+ GFQ L+ LN P+ +L +GNALF + F++ +KTLY + F T+F Sbjct: 73 PMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDF 132 Query: 163 RDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQE-Q 221 + + A ++IN +V QTKGK+V L+++L N ++++VNYI FKA+W F+ T++ Sbjct: 133 SNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSS 192 Query: 222 DFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENG 281 F + T V+VPMM + +QY++L+D L+C V+ + Y NA ALF+LP EG+M+ VE Sbjct: 193 SFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEAA 252 Query: 282 LSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSN 341 +S KTL+KW ++ +K ++L++PKFSI +Y L L +GI + ++ +AD SG++ + Sbjct: 253 MSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNG 312 Query: 342 IQVSEMVHKAVVEVDESGTRAAAA 365 +++S HKAV+ + E GT AA A Sbjct: 313 LKLSNAAHKAVLHIGEKGTEAAGA 336 >2V95-A nrPDB Length = 371 Score = 263 bits (671), Expect = 1e-70, Method: Compositional matrix adjust. Identities = 137/355 (38%), Positives = 215/355 (60%), Gaps = 8/355 (2%) Query: 40 VAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNL 99 +AP++ DF F+LY+ L + P ++ SPVSISM+LAM+SLG S + Q L+ LG NL Sbjct: 9 LAPTNV-DFAFNLYQRLVALNPDKNTLISPVSISMALAMVSLG---SAQTQSLQSLGFNL 64 Query: 100 QKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFP 159 ++SE E+H+ FQ L L Q G ++++GNA+F + L+D+F++ +K Y ++ Sbjct: 65 TETSEAEIHQSFQYLNYLLKQSDTGLEMNMGNAMFLLQKLKLKDSFLADVKQYYESEALA 124 Query: 160 TNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQ 219 +F D A +QIN +V +T+GKI + +LDS A I+VNYIF + WE F+ + T+ Sbjct: 125 IDFEDWTKASQQINQHVKDKTQGKIEHVFSDLDSPASFILVNYIFLRGIWELPFSPENTR 184 Query: 220 EQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVE 279 E+DFYV + V+VPMM + Y D C+++ + Y GN TA FILP +G+M V Sbjct: 185 EEDFYVNETSTVKVPMMVQSGSIGYFRDSVFPCQLIQMDYVGNGTAFFILPDQGQMDTVI 244 Query: 280 NGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNH 339 LS T+ +W K+ RQ+ LY+PKFS+ +Y L+ VL L I ++ T+ +D SG + Sbjct: 245 AALSRDTIDRWGKLMTPRQVNLYIPKFSMSDTYDLKDVLEDLNIKDLLTNQSDFSGNTKD 304 Query: 340 SNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVD 394 + ++ MVHKA++++DE + G RS L+ + FN+PF++ + D Sbjct: 305 VPLTLT-MVHKAMLQLDEGNVLPNSTNGAPLHLRSEPLD---IKFNKPFILLLFD 355 >1BY7-A nrPDB Length = 382 Score = 195 bits (495), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 121/390 (31%), Positives = 213/390 (54%), Gaps = 22/390 (5%) Query: 31 VEDLHVGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQ 90 +EDL V T+ F +L++ LA A+P+Q++F SP SIS ++AM+ +G+ ST+ Q Sbjct: 1 MEDLCVANTL-------FALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQ 53 Query: 91 ILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMK 150 + + L N ++ ++H F+ L +N + L N LF + ++ ++ + Sbjct: 54 MAKVLQFNEVGAAADKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQ 113 Query: 151 TLYLADTFPTNFRDSA-GAMKQINDYVAKQTKGKIVDLLK--NLDSNAVVIMVNYIFFKA 207 Y ++ +F + A A K+IN +V QTKGKI +LL ++D + +++VN ++FK Sbjct: 114 KYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKG 173 Query: 208 KWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALF 267 KW+T F K F V S V MM ++ + +L +++ +PY G+ + Sbjct: 174 KWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFL 233 Query: 268 ILPSE-----GKMQQVENGLSEKTLRKWLKMFK--KRQLELYLPKFSIEGSYQLEKVLPS 320 +LP E ++ +E+ ++ L KW K + ++E+Y+P+F +E Y+L +L S Sbjct: 234 LLPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRS 293 Query: 321 LGISNVFT-SHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNS 379 +G+ + F A+ SG+S +++ +SE+ H+A+V+V+E GT AAA TG + T R+ Sbjct: 294 MGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGP 353 Query: 380 QRLVFNRPFLMFI---VDNNILFLGKVNRP 406 Q V + PFL I + N ILF G+ + P Sbjct: 354 Q-FVADHPFLFLIMHKITNCILFFGRFSSP 382 >4AJT-A nrPDB Length = 427 Score = 189 bits (479), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 117/365 (32%), Positives = 198/365 (54%), Gaps = 11/365 (3%) Query: 48 FTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLN-LQKSSEKE 106 F F+L R + S ++ FSP +S+++ L LG TK+QI GL L L ++ Sbjct: 65 FGFNLLRKI-SMRHDGNVIFSPFGLSVAMVNLMLGTKGETKVQIENGLNLQALSQAGPLI 123 Query: 107 LHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSA 166 L F+++ + + RD LS G+ F D+++T+ + K + + NF++S+ Sbjct: 124 LPALFKKVKETFSSNRD-LGLSQGSFAFIHKDFDIKETYFNLSKKYFDIEYVSINFQNSS 182 Query: 167 GAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVT 226 A IN + K+T+GKI L ++ +I+V+Y+ FK KW T F+ T+ F++ Sbjct: 183 QARGLINHCIVKETEGKIPKLFDEINPETKLILVDYVLFKGKWLTPFDPSFTEADTFHLD 242 Query: 227 SETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSE-GKMQQVENGLSEK 285 ++VPMM RE + D+ C ++ +PYQGNAT L +L + G +E+ L+ Sbjct: 243 KYRAIKVPMMYREGNFTSTFDKKFRCHILKLPYQGNATMLVVLMEKTGDYLALEDYLTVD 302 Query: 286 TLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHS-NIQV 344 + WL+ K R++E++ PKF + Y++ ++L +GI +F++ ADLS +S + N+QV Sbjct: 303 LVETWLQNMKTRKMEVFFPKFKLNQRYEMHELLKQMGIRRLFSTSADLSELSAMARNLQV 362 Query: 345 SEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDN---NILFLG 401 S ++ ++V+EVDE GT A + T + S + NRPF I + +LFLG Sbjct: 363 SRVLQQSVLEVDERGTEAVSGTLSEIIAYSM---PPAIKVNRPFHFIIYEEMSRMLLFLG 419 Query: 402 KVNRP 406 +V P Sbjct: 420 RVVNP 424 >4AJU-A nrPDB Length = 387 Score = 188 bits (477), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 108/329 (32%), Positives = 179/329 (54%), Gaps = 3/329 (0%) Query: 47 DFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKE 106 +F F L R + S ++ FSP +S+++ L LGA T+ QI GL L K ++ Sbjct: 60 NFGFSLLRKI-SMRHDGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPG 118 Query: 107 LHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSA 166 L + L+E L+ G+ F D+++TF + K + + P NFR+++ Sbjct: 119 LLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNAS 178 Query: 167 GAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVT 226 A + +N Y+ K+T+GKI L ++ +I+V+YI FK KW T F+ T+ F++ Sbjct: 179 QAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLD 238 Query: 227 SETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSE-GKMQQVENGLSEK 285 ++VPMM ++ D+N C V+ +PYQGNAT L +L + G +E+ L+ Sbjct: 239 KYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTTD 298 Query: 286 TLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGIS-NHSNIQV 344 + WL+ K R +E++ PKF ++ Y++ ++L +GI +F+ ADLS +S N+QV Sbjct: 299 LVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQV 358 Query: 345 SEMVHKAVVEVDESGTRAAAATGTIFTFR 373 S ++ + V+EVDE GT A A + T R Sbjct: 359 SRVLQRTVIEVDERGTEAVAGILSEITAR 387 >2H4Q-A nrPDB Length = 382 Score = 187 bits (475), Expect = 8e-48, Method: Compositional matrix adjust. Identities = 113/350 (32%), Positives = 192/350 (54%), Gaps = 15/350 (4%) Query: 33 DLHVGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQIL 92 +L + +S +FT DL+ L ++IFFSP SIS +LA+ L A ST ++ Sbjct: 37 ELEISMEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMA 96 Query: 93 EGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTL 152 E L + +H GF++LL N+PR+ + L N ++ + L T++ K Sbjct: 97 EVLHF----EQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTYLQLSKKY 152 Query: 153 YLADTFPTNFRDS-AGAMKQINDYVAKQTKGKIVDLLKNLDSNAV--VIMVNYIFFKAKW 209 Y A+ NF+ + + K+IN +V KQT+ KI +LL + D A +I+VN I+FKA+W Sbjct: 153 YKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILVNAIYFKAEW 212 Query: 210 ETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFIL 269 E F + T Q F ++ V MM D + L+ ++ +++ +PY ++FIL Sbjct: 213 EVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPYVKRELSMFIL 272 Query: 270 -PSEGK-----MQQVENGLSEKTLRKWL--KMFKKRQLELYLPKFSIEGSYQLEKVLPSL 321 P + K ++Q+E L+ + L +W KM + ++L+LPKFS+E L L ++ Sbjct: 273 LPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDRIDLRDTLRNM 332 Query: 322 GISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFT 371 G++ FT++AD G+++ ++ +S+++H++ V VDE GT A AAT I + Sbjct: 333 GMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAVAATAVIIS 382 >2H4P-A nrPDB Length = 394 Score = 182 bits (462), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 114/374 (30%), Positives = 196/374 (52%), Gaps = 35/374 (9%) Query: 33 DLHVGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQIL 92 +L + +S +FT DL+ L ++IFFSP SIS +LA+ L A ST ++ Sbjct: 21 ELEISMEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMA 80 Query: 93 EGLG------------------------LNLQKSSEKELHRGFQQLLQELNQPRDGFQLS 128 E L ++ + + +H GF++LL N+PR+ + L Sbjct: 81 EVLHFTEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLR 140 Query: 129 LGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAG-AMKQINDYVAKQTKGKIVDL 187 N ++ + L T++ K Y A+ NF+ + + K+IN +V KQT+ KI +L Sbjct: 141 SANRIYVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNL 200 Query: 188 LKNLDSNAV--VIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYL 245 L + D A +I+VN I+FKA+WE F + T Q F ++ V MM D + L Sbjct: 201 LSSDDVKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVL 260 Query: 246 LDRNLSCRVVGVPYQGNATALFIL-PSEGK-----MQQVENGLSEKTLRKWL--KMFKKR 297 + ++ +++ +PY ++FIL P + K ++Q+E L+ + L +W KM + Sbjct: 261 IMEKMNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTET 320 Query: 298 QLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDE 357 ++L+LPKFS+E L L ++G++ FT++AD G+++ ++ +S+++H++ V VDE Sbjct: 321 LVDLHLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDE 380 Query: 358 SGTRAAAATGTIFT 371 GT AAAAT I + Sbjct: 381 KGTEAAAATAVIIS 394 >4ZK0-A nrPDB Length = 390 Score = 179 bits (455), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 119/381 (31%), Positives = 206/381 (54%), Gaps = 23/381 (6%) Query: 48 FTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILE------------GL 95 F FDL++ + + +IF+SP+SI+ +L M+ LGA +T QI + G Sbjct: 11 FMFDLFQQFRKSKEN-NIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQVTENTTGK 69 Query: 96 GLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLA 155 +H FQ+LL E N+ D ++L + N LF + ++ A+K Y Sbjct: 70 AATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLDAIKKFYQT 129 Query: 156 DTFPTNFRDS-AGAMKQINDYVAKQTKGKIVDLLK--NLDSNAVVIMVNYIFFKAKWETS 212 +F ++ + K+IN +V QT KI +L+ N+ SN +++VN I+FK +WE Sbjct: 130 SVESVDFANAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKK 189 Query: 213 FNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFIL-PS 271 FN + T+E+ F+ T + MM + +H+ ++ +V+ +PY+G ++ +L P+ Sbjct: 190 FNKEDTKEEKFWPNKNTYKSIQMMRQYTSFHFASLEDVQAKVLEIPYKGKDLSMIVLLPN 249 Query: 272 E-GKMQQVENGLSEKTLRKW--LKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFT 328 E +Q++E L+ + L +W L+ ++ +++L+LP+F +E SY L+ L ++G+ ++F Sbjct: 250 EIDGLQKLEEKLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLRTMGMVDIFN 309 Query: 329 SHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPF 388 ADLSG++ + +S ++HKA VEV E G AAAAT + S ++ N PF Sbjct: 310 GDADLSGMTGSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFGSSPTSTNEEFHCNHPF 369 Query: 389 LMFIVD---NNILFLGKVNRP 406 L FI N+ILF G+ + P Sbjct: 370 LFFIRQNKTNSILFYGRFSSP 390 >3NDA-A nrPDB Length = 377 Score = 178 bits (451), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 118/367 (32%), Positives = 202/367 (55%), Gaps = 13/367 (3%) Query: 48 FTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKEL 107 F L RAL S P +++FFSP S+S ++ M GA T+ ++ +GLG + ++ + Sbjct: 14 FGLRLLRALPSG-PEKNVFFSPYSVSTAMGMAFAGARGQTQQELSQGLGFSDVDLTDAGV 72 Query: 108 HRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFR-DSA 166 + + L L + NA + L +++ SA+++ + A+ +F + Sbjct: 73 LDAYTHHTERLKSTPSNSTLDVANAAAIQRTLALLNSYESALQSSFGAELHKVDFAGEPQ 132 Query: 167 GAMKQINDYVAKQTKGKIVDLLKN-LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYV 225 A+ +N++V ++T KI L LD + +++++N I+FK +W T+F + T+++ F+ Sbjct: 133 AAVDFVNNWVKRKTHDKIEKLFNEPLDPDTLLVLLNAIYFKGEWNTAFVKEHTEKRQFFN 192 Query: 226 TSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQG-NATALFILPSEGK-MQQVENGLS 283 T V V M E + Y +L VV +PY+G + T +LP E ++ ++ L+ Sbjct: 193 GGVTPVEVDTMRLEARIKYRFFDDLQVEVVELPYRGLDYTMAILLPKENTGVEGLKQNLT 252 Query: 284 EKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQ 343 + +L ++R++ + LPKF +E Y L+ L SLGI +F S ADLSGI N +++ Sbjct: 253 IDRFQNYLSDLRERKITVLLPKFKLETKYSLKAPLQSLGIKQIFESGADLSGI-NDGSLR 311 Query: 344 VSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVF--NRPFLMFIVD---NNIL 398 VS + HKAVVEV+E GT AAA TG + S L + +VF + PFL FI + ++I Sbjct: 312 VSAVEHKAVVEVNEEGTVAAATTGVVIVPYS--LGPEPVVFRVDHPFLFFIRNTRTDDIF 369 Query: 399 FLGKVNR 405 F+G+VN+ Sbjct: 370 FVGQVNK 376 >5INW-A nrPDB Length = 421 Score = 177 bits (450), Expect = 6e-45, Method: Compositional matrix adjust. Identities = 105/323 (32%), Positives = 178/323 (55%), Gaps = 6/323 (1%) Query: 50 FDLYR-ALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLN--LQKSSEKE 106 F LY+ L A P+ +IFFSP+SI+ +L +++ GA ST+ ++ LG L + + Sbjct: 90 FRLYKQVLGGAGPADNIFFSPLSIASALGVVTAGANGSTRAELDTALGFKEFLHGKKKAK 149 Query: 107 LHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSA 166 + F +L L + GF+L N +F+ + L F + L+ ++ +F DS Sbjct: 150 SMKYFARLNGALYKRSAGFELMGKNVVFSKKGLWLYRQFTRTVAHLFKSNVRSVDFGDSK 209 Query: 167 GAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVT 226 A++ +N Y+ K T K D++ ++D++ +++VN I+FK W F T+ F+V Sbjct: 210 NAVELMNAYIEKVTSKKFPDVISDVDTDTSLVIVNVIYFKGSWGNKFEPDLTKNVRFWVN 269 Query: 227 SETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGK-MQQVENGLSEK 285 S + VP M + + Y DR L VV +PY+G A+ L I+P + + +VE +S++ Sbjct: 270 SSYSMMVPTMHQRAKLSYTQDRKLRSTVVKLPYEGGASMLVIVPHRTEDLPKVEESVSQE 329 Query: 286 TLRKWLKMF--KKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQ 343 L +WL + ++L LPKF I SY L+ L ++G+S++F+ ADLS I+ + Sbjct: 330 QLEEWLSLLGPSNHYVQLSLPKFKISVSYDLKAYLSAMGMSSMFSYGADLSRITGMQKLH 389 Query: 344 VSEMVHKAVVEVDESGTRAAAAT 366 V ++ HK+V+ V+E GT A A T Sbjct: 390 VDKITHKSVLHVNEEGTEAKAET 412 >1UHG-A nrPDB Length = 385 Score = 176 bits (446), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 111/380 (29%), Positives = 203/380 (53%), Gaps = 23/380 (6%) Query: 47 DFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQI--------LEGLG-- 96 +F FD+++ L +++IF+ P++I +LAM+ LGA ST+ QI L G G Sbjct: 9 EFCFDVFKELKVHHANENIFYCPIAIMSALAMVYLGAKDSTRTQINKVVRFDKLPGFGDS 68 Query: 97 LNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLAD 156 + Q + +H + +L ++ +P D + SL + L+ + + ++ +K LY Sbjct: 69 IEAQCGTSVNVHSSLRDILNQITKPNDVYSFSLASRLYAEERYPILPEYLQCVKELYRGG 128 Query: 157 TFPTNFRDSAGAMKQ-INDYVAKQTKGKIVDLLK--NLDSNAVVIMVNYIFFKAKWETSF 213 P NF+ +A ++ IN +V QT G I ++L+ ++DS +++VN I FK WE +F Sbjct: 129 LEPINFQTAADQARELINSWVESQTNGIIRNVLQPSSVDSQTAMVLVNAIVFKGLWEKAF 188 Query: 214 NHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPY-QGNATALFILPSE 272 + TQ F VT + V MM + + + +++ +P+ G + L +LP E Sbjct: 189 KDEDTQAMPFRVTEQESKPVQMMYQIGLFRVASMASEKMKILELPFASGTMSMLVLLPDE 248 Query: 273 -GKMQQVENGLSEKTLRKWL--KMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTS 329 ++Q+E+ ++ + L +W + ++R++++YLP+ +E Y L VL ++GI++VF+S Sbjct: 249 VSGLEQLESIINFEKLTEWTSSNVMEERKIKVYLPRMKMEEKYNLTSVLMAMGITDVFSS 308 Query: 330 HADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFL 389 A+LSGIS+ ++++S+ VH A E++E+G G+ A S+ + PFL Sbjct: 309 SANLSGISSAESLKISQAVHAAHAEINEAGRE---VVGSAEAGVDAASVSEEFRADHPFL 365 Query: 390 MF---IVDNNILFLGKVNRP 406 I N +LF G+ P Sbjct: 366 FCIKHIATNAVLFFGRCVSP 385 >4EB1-I nrPDB Length = 440 Score = 170 bits (430), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 118/385 (30%), Positives = 211/385 (54%), Gaps = 31/385 (8%) Query: 48 FTFDLYRALA-SAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLN-LQKSSEK 105 F Y+ LA S + +IF SP+SIS + AM LGA + T Q++E + + + + Sbjct: 58 FATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSD 117 Query: 106 ELHRGFQQLLQEL-NQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRD 164 ++H F +L L + +L N LF D + +T+ + +Y A P +F++ Sbjct: 118 QIHFFFAKLNCRLYRKANKASKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKE 177 Query: 165 SAGAMKQ-INDYVAKQTKGKIVDL----------LKNLDSNAVVIMVNYIFFKAKWETSF 213 +A + IN +V+ +T+G+I D+ L N ++ V+++VN I+FK W++ F Sbjct: 178 NAEQSRAAINKWVSNKTEGRITDVIPSEAINVLVLVNTRTSTVLVLVNTIYFKGLWKSKF 237 Query: 214 NHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLS--CRVVGVPYQGN-ATALFILP 270 + + T+++ FY MM +E ++ Y R ++ +V+ +P++G+ T + ILP Sbjct: 238 SPENTRKELFYKADGESCSASMMYQEGKFRY---RRVAEGTQVLELPFKGDDITMVLILP 294 Query: 271 S-EGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTS 329 E + +VE L+ + L++WL ++ L +++P+F IE + L++ L +G+ ++F+ Sbjct: 295 KPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSP 354 Query: 330 H-ADLSGI--SNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVF-- 384 + L GI ++ VS+ HKA +EV+E G+ AAA+T + RS LN R+ F Sbjct: 355 EKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRS--LNPNRVTFKA 412 Query: 385 NRPFLMFIVD---NNILFLGKVNRP 406 NRPFL+FI + N I+F+G+V P Sbjct: 413 NRPFLVFIREVPLNTIIFMGRVANP 437 >1HLE-A nrPDB Length = 345 Score = 169 bits (429), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 101/321 (31%), Positives = 185/321 (57%), Gaps = 16/321 (4%) Query: 48 FTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKEL 107 F DL+RAL + P+ +IF SP+SIS +LAM+ LG +T Q+ + L + + +++ Sbjct: 12 FAVDLFRALNESDPTGNIFISPLSISSALAMIFLGTRGNTAAQVSKALYFD----TVEDI 67 Query: 108 HRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSA- 166 H FQ L ++N+P + L L N L+ + + F+++ + +Y A+ +F+ + Sbjct: 68 HSRFQSLNADINKPGAPYILKLANRLYGEKTYNFLADFLASTQKMYGAELASVDFQQAPE 127 Query: 167 GAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFY 224 A K+IN++V QT+GKI +LL +D+ +++VN I+FK W+ F + T++ F Sbjct: 128 DARKEINEWVKGQTEGKIPELLVKGMVDNMTKLVLVNAIYFKGNWQQKFMKEATRDAPFR 187 Query: 225 VTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFI-LPSEGK-----MQQV 278 + + V MM ++ ++ Y +L CRV+ +PYQG ++ I LP + + ++++ Sbjct: 188 LNKKDTKTVKMMYQKKKFPYNYIEDLKCRVLELPYQGKELSMIILLPDDIEDESTGLEKI 247 Query: 279 ENGLSEKTLRKWLK--MFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFT-SHADLSG 335 E L+ LR+W K ++ ++LP+F +E SY L L LG+ ++F ADLSG Sbjct: 248 EKQLTLDKLREWTKPENLYLAEVNVHLPRFKLEESYDLTSHLARLGVQDLFNRGKADLSG 307 Query: 336 ISNHSNIQVSEMVHKAVVEVD 356 +S ++ VS+++HK+ V+++ Sbjct: 308 MSGARDLFVSKIIHKSFVDLN 328 >4GA7-A nrPDB Length = 389 Score = 169 bits (427), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 128/379 (33%), Positives = 207/379 (54%), Gaps = 20/379 (5%) Query: 43 SSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKS 102 S+ F DL+ AL+ P+ +IF SP SIS ++AM+ LG +T Q+ + N Sbjct: 16 SANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHFN---- 71 Query: 103 SEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNF 162 + +E+H FQ L ++N+ + L L N L+ + + F+ + + Y AD +F Sbjct: 72 TVEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDF 131 Query: 163 RD-SAGAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQ 219 + S A K IN +V QT+GKI +LL + +D+ +++VN I+FK W+ F + T Sbjct: 132 QHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATT 191 Query: 220 EQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFI-LPSEGK---- 274 F + + V MM ++ ++ Y +L CRV+ +PYQG ++ I LP + + Sbjct: 192 NAPFRLNKKDRKTVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIEDEST 251 Query: 275 -MQQVENGLSEKTLRKWLK--MFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVF-TSH 330 ++++E L+ + L +W K ++ + LP+F +E SY L L LG+ ++F +S Sbjct: 252 GLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSK 311 Query: 331 ADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLM 390 ADLSG+S +I +S++VHK+ VEV+E GT AAAAT I TF + + PFL Sbjct: 312 ADLSGMSGARDIFISKIVHKSFVEVNEEGTEAAAATAGIATF-CMDDPEENFTADHPFLF 370 Query: 391 FIVDN---NILFLGKVNRP 406 FI N +ILFLG+ + P Sbjct: 371 FIRHNSSGSILFLGRFSSP 389 >1ATT-A nrPDB Length = 429 Score = 168 bits (426), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 118/377 (31%), Positives = 211/377 (55%), Gaps = 23/377 (6%) Query: 48 FTFDLYRALA-SAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLN-LQKSSEK 105 F Y+ LA S + +IF SP+SIS + AM LGA ++T Q++E + + + + Sbjct: 55 FATAFYQHLADSKNNNDNIFLSPLSISTAFAMTKLGACNNTLTQLMEVFKFDTISEKTSD 114 Query: 106 ELHRGFQQLLQEL-NQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRD 164 ++H F +L L + +L N LF D + +T+ + +Y A P +F+ Sbjct: 115 QIHFFFAKLNCRLYRKANKSSELVSANRLFGDKSITFNETYQDISEVVYGAKLQPLDFKG 174 Query: 165 SAGAMK-QINDYVAKQTKGKIVDLL--KNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQ 221 +A + IN +++ +T+G+I D++ + ++ V+++VN I+FK W++ F+ + T+++ Sbjct: 175 NAEQSRLTINQWISNKTEGRITDVIPPQAINEFTVLVLVNTIYFKGLWKSKFSPENTRKE 234 Query: 222 DFYVTSETVVRVPMMSREDQYHYLLDRNL--SCRVVGVPYQGN-ATALFILPS-EGKMQQ 277 FY V MM +E ++ Y R + S +V+ +P++G+ T + ILP E + + Sbjct: 235 LFYKADGESCSVLMMYQESKFRY---RRVAESTQVLELPFKGDDITMVLILPKLEKTLAK 291 Query: 278 VENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSH-ADLSGI 336 VE L+ L++WL + L +++P+F IE S+ +++ L +G+ ++F+ + L GI Sbjct: 292 VEQELTPDMLQEWLDELTETLLVVHMPRFRIEDSFSVKEQLQDMGLEDLFSPEKSRLPGI 351 Query: 337 --SNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVF--NRPFLMFI 392 S++ VS+ HKA +EV+E G+ AAA+T RS LNS R+ F NRPFL+ I Sbjct: 352 VAEGRSDLYVSDAFHKAFLEVNEEGSEAAASTVISIAGRS--LNSDRVTFKANRPFLVLI 409 Query: 393 VD---NNILFLGKVNRP 406 + N I+F+G+V P Sbjct: 410 REVALNTIIFMGRVANP 426 >3LW2-A nrPDB Length = 379 Score = 167 bits (424), Expect = 6e-42, Method: Compositional matrix adjust. Identities = 111/373 (29%), Positives = 196/373 (52%), Gaps = 20/373 (5%) Query: 47 DFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKE 106 DF +++ + A+ +++ FSP +S LAML + T+ QI + +G K +EK Sbjct: 14 DFGVKVFQQVVQASKDRNVVFSPYGVSSVLAMLQMTTAGKTRRQIQDAMGF---KVNEKG 70 Query: 107 LHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSA 166 +QL +EL P + ++S +A+F ++L F+ L+ +F + Sbjct: 71 TAHALRQLSKELMGPWNKNEISTADAIFVQRDLELVQGFMPHFFKLFQTMVKQVDFSEVE 130 Query: 167 GAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFY 224 A IND+V + TKG I DLL +D +++VN ++F +W+T F T ++ F+ Sbjct: 131 RARFIINDWVERHTKGMINDLLAKGAVDELTRLVLVNALYFSGQWKTPFLEASTHQRLFH 190 Query: 225 VTSETVVRVPMMSREDQYHY---LLDRNLSCRVVGVPYQGNATALFI---LPSEGKMQQV 278 + + V VPMM++ ++++Y L VV +PYQG+ ++FI + + + Sbjct: 191 KSDGSTVSVPMMAQSNKFNYTEFTTPDGLEYDVVELPYQGDTLSMFIAAPFEKDVHLSAL 250 Query: 279 ENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSH-ADLSGIS 337 N L + +R+W + L LPKFS+E L L LG+ ++F++ AD + +S Sbjct: 251 TNILDAELIRQWKGNMTRLPRLLILPKFSLETEVDLRGPLEKLGMPDMFSATLADFTSLS 310 Query: 338 NHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNN- 396 + + V++ + K +EV+ESGT A+++T + SAR+ +V +R FL F+V +N Sbjct: 311 DQEQLSVAQALQKVRIEVNESGTVASSSTAFVI---SARMAPTEMVIDRSFL-FVVRHNP 366 Query: 397 ---ILFLGKVNRP 406 ILF+G+V P Sbjct: 367 TETILFMGQVMEP 379 >1C5G-A nrPDB Length = 402 Score = 164 bits (415), Expect = 7e-41, Method: Compositional matrix adjust. Identities = 117/415 (28%), Positives = 212/415 (51%), Gaps = 35/415 (8%) Query: 5 LLLCLVLLSPQGASLHRHHPREMKKRVEDLHVGATVAPSSRRDFTFDLYRALASAAPSQS 64 L+L L L+ +G+++H H P + H+ + DF +++ +A A+ ++ Sbjct: 10 LVLGLALVFGEGSAVH-HPPSYVA------HLAS--------DFGVRVFQQVAQASKDRN 54 Query: 65 IFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDG 124 + FSP ++ LAML L G T+ QI +G K +K + + L +EL P + Sbjct: 55 VVFSPYGVASVLAMLQLTTGGETQQQIQAAMGF---KIDDKGMAPALRHLYKELMGPWNK 111 Query: 125 FQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKI 184 ++S +A+F + L F+ L+ + +F + A IND+V TKG I Sbjct: 112 DEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMI 171 Query: 185 VDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQY 242 +LL +D +++VN ++F +W+T F T + F+ + + V VPMM++ +++ Sbjct: 172 SNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKF 231 Query: 243 HY---LLDRNLSCRVVGVPYQGNATALFI---LPSEGKMQQVENGLSEKTLRKWLKMFKK 296 +Y ++ +PY G+ ++FI E + + N LS + + W + Sbjct: 232 NYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTR 291 Query: 297 RQLELYLPKFSIEGSYQLEKVLPSLGISNVFTS-HADLSGISNHSNIQVSEMVHKAVVEV 355 L LPKFS+E L K L +LG++++F AD + +S+ + V++ + K +EV Sbjct: 292 LPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEV 351 Query: 356 DESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNN----ILFLGKVNRP 406 +ESGT A+++T I SAR+ + ++ +RPFL F+V +N +LF+G+V P Sbjct: 352 NESGTVASSSTAVIV---SARMAPEEIIMDRPFL-FVVRHNPTGTVLFMGQVMEP 402 >3F02-A nrPDB Length = 359 Score = 163 bits (412), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 92/344 (26%), Positives = 186/344 (54%), Gaps = 14/344 (4%) Query: 37 GATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLG 96 GAT + D + ++Y L + ++I FSP+SI++++ M+ LGA ST+ +I +G Sbjct: 15 GATFPEEAIADLSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMG 74 Query: 97 LN-LQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLA 155 + L+ E + F ++ + + + N+LF + + F+ MK + A Sbjct: 75 YDSLKNGEEFSFLKEFSNMV---TAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNA 131 Query: 156 DTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLL--KNLDSNAVVIMVNYIFFKAKWETSF 213 +F + IN +V T + DL+ ++ D+ + ++N ++FK W++ F Sbjct: 132 AVNHVDFSQNVAVANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQF 191 Query: 214 NHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLS------CRVVGVPYQGNATALF 267 + T+ F E+ V++PMM ++ +++Y + S +V+ +PY+G+ ++ Sbjct: 192 RPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMM 251 Query: 268 ILPS--EGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISN 325 ++ S E + +E + + + +W KK+++E+YLP+F++E L+ VL +LGI+ Sbjct: 252 LVLSRQEVPLATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITE 311 Query: 326 VFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTI 369 +F A+L+G+S++ I +S+ +HK+ +EV+E G+ AAA +G I Sbjct: 312 IFIKDANLTGLSDNKEIFLSKAIHKSFLEVNEEGSEAAAVSGMI 355 >1JMJ-A nrPDB Length = 480 Score = 161 bits (408), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 108/369 (29%), Positives = 186/369 (50%), Gaps = 15/369 (4%) Query: 48 FTFDLYRALASAAPS-QSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLN--LQKSSE 104 F F+LYR L + +IF +PV IS ++ M+SLG T Q+ L + SS+ Sbjct: 114 FAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSK 173 Query: 105 KEL---HRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTN 161 E+ H F++L L + G+ L N L+ + F + ++ Y A+ + Sbjct: 174 YEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIAD 233 Query: 162 FRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQ 221 F D A + + N+++ K TKG I D L+N+D ++++N I+FK W F + T Sbjct: 234 FSDPA-FISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNH 292 Query: 222 DFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSE-GKMQQVEN 280 +F + VV+V MM + + D+ L C ++ + Y G + L ++P + M+ +E Sbjct: 293 NFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEA 352 Query: 281 GLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHS 340 L+ + + +W K R E+ LPKF +E +Y L + L +GI +F + +++GIS+ Sbjct: 353 QLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQR 412 Query: 341 NIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNN---I 397 I + H+ + V+E GT+A T F S ++ R +RPFL I ++ + Sbjct: 413 -IAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQV---RFTVDRPFLFLIYEHRTSCL 468 Query: 398 LFLGKVNRP 406 LF+G+V P Sbjct: 469 LFMGRVANP 477 >3ZHA-A nrPDB Length = 392 Score = 159 bits (401), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 108/377 (28%), Positives = 191/377 (50%), Gaps = 14/377 (3%) Query: 37 GATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLG 96 AT+A S F LY+A+A ++I SPV ++ SL ++SLG ++T Q Sbjct: 6 AATLAERSA-GLAFSLYQAMAKDQAVENILLSPVVVASSLGLVSLGGKATTASQA--KAV 62 Query: 97 LNLQKSSEKELHRGFQQLLQEL-NQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLA 155 L+ ++ ++E+H G +LL+ L N LG+ L+ V + FV + K Y Sbjct: 63 LSAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFAEDFVRSSKQHYNC 122 Query: 156 DTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNH 215 + NFRD A++ IN++ A+ T GK+ ++ K+++ ++VN +FFK W+ F+H Sbjct: 123 EHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHH 182 Query: 216 KGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFIL-PSEGK 274 K + F VT V V MM R Y+Y D ++V +P ++L IL P + Sbjct: 183 KMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVE 242 Query: 275 -MQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSH-AD 332 ++++E L+++ L+ W+ +K+ + + LPK +E ++ L+K L LG++ + AD Sbjct: 243 PLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKAD 302 Query: 333 LSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFI 392 LS +S ++ ++ + H E D G RS +L + PF+ + Sbjct: 303 LSRMSGKKDLYLASVFHATAFEWDTEGNPFDQDIYGREELRSPKL----FYADHPFIFLV 358 Query: 393 VD---NNILFLGKVNRP 406 D ++LF+G++ RP Sbjct: 359 RDTQSGSLLFIGRLVRP 375 >4DY0-A nrPDB Length = 379 Score = 149 bits (376), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 104/375 (27%), Positives = 195/375 (52%), Gaps = 34/375 (9%) Query: 52 LYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGL--GLNLQKSSEKELHR 109 ++ + + P +I SP I+ L ML LGA TK Q+ + G+N Sbjct: 19 VFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN----------- 67 Query: 110 GFQQLLQELNQP----RDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDS 165 G ++L+++N+ ++ +++ NA+F +++ FV+ K ++ + NF D Sbjct: 68 GVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDP 127 Query: 166 AGAMKQINDYVAKQTKGKIVDLLKNLDSNAVV---IMVNYIFFKAKWETSFNHKGTQEQD 222 A A IN +V +T+ I +LL + V+ ++VN ++FK W++ F + T+++ Sbjct: 128 ASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRT 187 Query: 223 FYVTSETVVRVPMMSREDQYHY---LLDRNLSCRVVGVPYQGNATALFI-LPSEGK--MQ 276 F +VPM+++ + +L + +PY G + ++ I LP+E + Sbjct: 188 FVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLS 247 Query: 277 QVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVF-TSHADLSG 335 + +S KT+ W+ + +++++ LPKF+ L++ L LGI+++F +S A+ + Sbjct: 248 AIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAK 307 Query: 336 ISNHS-NIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVD 394 I+ S N+ VS ++ KA +EV E GT+A+AAT I RS+ + +RPFL FI Sbjct: 308 ITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSS---PPWFIVDRPFLFFIRH 364 Query: 395 N---NILFLGKVNRP 406 N +LF+G++N+P Sbjct: 365 NPTGAVLFMGQINKP 379 >4KDS-A nrPDB Length = 386 Score = 149 bits (375), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 100/372 (26%), Positives = 194/372 (52%), Gaps = 21/372 (5%) Query: 47 DFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKE 106 DF ++ +A + ++ FSP ++ LAM LGAG +T + LG +LQ E+ Sbjct: 21 DFGMRVFSQVAQNSKGSNLAFSPYGVATILAMAQLGAGGNTLKTLNAKLGFSLQ---ERG 77 Query: 107 LHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSA 166 + R Q+LLQ +G +L+ G + + + L+ F + + A +F Sbjct: 78 MARQ-QRLLQRDISSEEGVELASG--VMVERKMALEKGFRRGLGKAFQASPHQLDFSRPD 134 Query: 167 GAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFY 224 A+ IN +V+ T G I L + L ++++N + F+ W+ F+ K T+E+ F+ Sbjct: 135 QALDIINAWVSDHTAGTIPSFLSSGALTDETRMVLLNALHFQGLWKVPFDPKMTEERLFH 194 Query: 225 VTSETVVRVPMMSREDQYHY---LLDRNLSCRVVGVPYQGNATALFILP---SEGKMQQV 278 + + V VPMM ++ Y + + V+ VPY+G + ++ ++ E + + Sbjct: 195 CANGSSVPVPMMRLTHRFKYGEFVTPDGVDYDVIEVPYEGESLSMLLVSPFEPETPVSSL 254 Query: 279 ENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFT-SHADLSGIS 337 + L+ + L++W + + + +L LP+F+++ +L+ +L +G+ ++F + AD + I+ Sbjct: 255 SSELTTQRLQQWRQEMRSVKRQLVLPRFTLDSEVELKSILIQMGLGDMFNLAKADFTRIT 314 Query: 338 NHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNN- 396 + VS+++ K +EV+E GT+A+AAT I +R+ + + NRPFL I + Sbjct: 315 TEQPLCVSKVLQKVKIEVNEEGTKASAATAAILF---SRMAVEEITMNRPFLFLIHHKST 371 Query: 397 --ILFLGKVNRP 406 +LF+G+VN+P Sbjct: 372 GAVLFMGQVNQP 383 >4P0F-A nrPDB Length = 393 Score = 147 bits (371), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 107/368 (29%), Positives = 185/368 (50%), Gaps = 15/368 (4%) Query: 48 FTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKEL 107 F+ ++Y L+ P ++I FSP SI AM LGA + T Q+ +GLGL S +++ Sbjct: 17 FSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQLDQGLGL--ASSDPEQI 74 Query: 108 HRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAG 167 F Q+L +D L + N +F L+ F + +L+ +F + Sbjct: 75 AHSFHQVLAAY---QDSQILRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNVQ 131 Query: 168 AMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYV 225 A IN++V ++T I DL+ L+S + +++VN I FK W+ F T+ F++ Sbjct: 132 AAATINNWVEQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHL 191 Query: 226 TSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQ-GNATALFILP-SEGKMQQVENGLS 283 E V+VPMMS ++++ Y L + +PY+ + + L +LP ++ + +E L Sbjct: 192 DGERTVQVPMMSLKERFRYADLPALDAMALELPYKDSDLSMLIVLPNTKTGLPALEEKLR 251 Query: 284 EKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSG-ISNHSNI 342 TL + + + ++ L LP+F E +L +V LG+S +F+ A+ + + + Sbjct: 252 LTTLSQITQSLYETKVALKLPRFKAEFQVELSEVFQKLGMSRMFSDQAEFGKMLQSPEPL 311 Query: 343 QVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLV---FNRPFLMFIVDNN--I 397 +VS ++HKA +EV+E GT AAAATG + A ++ + + + PF +V Sbjct: 312 KVSAIIHKAFIEVNEEGTEAAAATGMAVRRKRAIMSPEEPIEFFADHPFTYVLVHQKDLP 371 Query: 398 LFLGKVNR 405 LF G V R Sbjct: 372 LFWGSVVR 379 >5NCS-A nrPDB Length = 375 Score = 139 bits (351), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 103/367 (28%), Positives = 183/367 (49%), Gaps = 21/367 (5%) Query: 48 FTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGL---GLNLQKSSE 104 F FDL + ++F SP+S+SM+L M GA T ++ L G ++ +E Sbjct: 14 FAFDLLQTTRKHVTEANVFISPLSVSMALNMTLNGAAGVTADEMKTALRETGYTMEDINE 73 Query: 105 KELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRD 164 L + L + + + N+++ +++ F+ A +T Y A+ +F Sbjct: 74 YS-----HSLREALLKVDPSTTIGMANSIWYKQGELVKEPFILANRTHYDAEVKAVDF-S 127 Query: 165 SAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFY 224 S + IN + A++T KI +L + NA + ++N ++FK W T F T+ F Sbjct: 128 SPATLPAINGWCAQKTNDKITKILDYIPGNAFMYLINAVYFKGIWVTQFKKSDTKRAPFR 187 Query: 225 VTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFI-LPSEGK-MQQVENGL 282 T V MM+++ + Y D C+ + + Y A ++ + LP+EG+ + V L Sbjct: 188 KADGTTQEVNMMAQKSTFGYTTDE--CCQYLEMDYGNKAFSMIVMLPNEGQTTRDVIEQL 245 Query: 283 SEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLE-KVLPSLGISNVFTSHADLSGISNHSN 341 K +K + Q+ L +P+F E Y LE K+LP +G++ FT AD GI++ + Sbjct: 246 DNKHWSMIIKGIRPTQVSLRMPRFKTECKYGLEKKILPEMGMNVPFTETADFPGITDAA- 304 Query: 342 IQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVF--NRPFLMFIVDNN--- 396 I +S ++HK V+VDE GT AAA T + +++ ++ + F N+PF+ I + + Sbjct: 305 IFISRVIHKTFVQVDEEGTEAAAVTA-VEMVKTSSPSTTPINFHINKPFVFAIREKSTGV 363 Query: 397 ILFLGKV 403 ILF+G++ Sbjct: 364 ILFIGEI 370 >1XQJ-A nrPDB Length = 389 Score = 137 bits (346), Expect = 7e-33, Method: Compositional matrix adjust. Identities = 96/374 (25%), Positives = 184/374 (49%), Gaps = 24/374 (6%) Query: 48 FTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKEL 107 F DL++ L+ P ++ FSP+++S SL++ +GA T +I G L + K++ Sbjct: 25 FAVDLFKQLSEKEPLGNVLFSPIALSTSLSLAQVGAKGDTANEI----GQVLHFENVKDV 80 Query: 108 HRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAG 167 GFQ + ++N+ + L L L+ D ++L F+S+ K Y + +F+D Sbjct: 81 PFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYAKELETVDFKDKLE 140 Query: 168 AMK-QINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFY 224 K QIN+ + T G ++L + ++ +++VN +F KW F+ T+E F Sbjct: 141 ETKGQINNSIKDLTDGHFENILADNSVNDQTKILVVNAAYFVGKWMKKFSESETKESPFR 200 Query: 225 VTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFI-LPSEGK-----MQQV 278 V V MM+ E + +++ +++ +P+Q ++FI LP + + ++++ Sbjct: 201 VNKTDTKPVQMMNMEATFSMGNIDSINSKIIELPFQNKHLSMFILLPKDVEDESTGLEKI 260 Query: 279 ENGLSEKTLRKWLK--MFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSH-ADLSG 335 E L+ ++L +W +++L +PKF +E + L +LG+ ++F+ +D SG Sbjct: 261 EKQLNSESLSQWTNPSTMANAKVKLSIPKFKVEKMIDPKASLENLGLKHIFSEDTSDFSG 320 Query: 336 ISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDN 395 +S + +S ++HK +E+ E G + G LN+ + PF+ I N Sbjct: 321 MSETKGVALSNVIHKVSLEITEDGGDSIEVPGARILQHKDELNA-----DHPFIYIIRHN 375 Query: 396 ---NILFLGKVNRP 406 NI+F GK + P Sbjct: 376 KTRNIIFFGKFSSP 389 >1IMV-A nrPDB Length = 398 Score = 137 bits (346), Expect = 7e-33, Method: Compositional matrix adjust. Identities = 101/373 (27%), Positives = 187/373 (50%), Gaps = 30/373 (8%) Query: 47 DFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKE 106 +F +DLYR +S +P+ ++ SP+S++ +L+ LSLGA T+ I L +L S + Sbjct: 40 NFGYDLYRVRSSMSPTTNVLLSPLSVATALSALSLGADERTESIIHRALYYDLISSPD-- 97 Query: 107 LHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSA 166 +H +++LL + P+ + S +F + + ++ +FV+ ++ Y T P + Sbjct: 98 IHGTYKELLDTVTAPQKNLK-SASRIVF-EKKLRIKSSFVAPLEKSY--GTRPRVLTGNP 153 Query: 167 G-AMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYV 225 +++IN++V Q KGK+ K + ++++ FK +W T F+ + T +DFY+ Sbjct: 154 RLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGVAHFKGQWVTKFDSRKTSLEDFYL 213 Query: 226 TSETVVRVPMMSREDQY-HYLLDRNLSCRVVGVPYQGNATALFILPSE--GKMQQVENGL 282 E VRVPMMS Y LD +LSC++ +P G+ + +F LP + + +E L Sbjct: 214 DEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSIIFFLPLKVTQNLTLIEESL 273 Query: 283 SEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNI 342 + + + + K Q L +PK + ++ K L + + ++F S D S I+ I Sbjct: 274 TSEFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLFDS-PDFSKITGKP-I 331 Query: 343 QVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVF------NRPFLMFIVDNN 396 +++++ H+A E +E G + G L L F N+PF+ + D + Sbjct: 332 KLTQVEHRAGFEWNEDGAGTTPSPG---------LQPAHLTFPLDYHLNQPFIFVLRDTD 382 Query: 397 ---ILFLGKVNRP 406 +LF+GK+ P Sbjct: 383 TGALLFIGKILDP 395 >4DTE-A nrPDB Length = 374 Score = 135 bits (339), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 92/372 (24%), Positives = 183/372 (49%), Gaps = 21/372 (5%) Query: 47 DFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKE 106 DF ++ +AP +++ SP I+ L M +GA +T + +G +LQ+ + Sbjct: 9 DFGLQVFAEAVQSAPDRNLALSPYGIASVLGMAQMGAYGATLKLLASKMGYSLQERGMPK 68 Query: 107 LHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSA 166 L R LLQ DG +++ G + D + L+ F ++ + + +F Sbjct: 69 LQR----LLQRDLASEDGVEVASG--VMVDRKIILEKVFRRSLSKAFQSVPHQIDFSQPE 122 Query: 167 GAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFY 224 A + IN + + T G I + L + L ++ +N + F W+T F+ + T+EQ F+ Sbjct: 123 MARQVINSWTSDHTDGMISEFLPSGVLSELTRLVFLNALHFHGVWKTPFDPRNTREQLFH 182 Query: 225 VTSETVVRVPMMSREDQYHY---LLDRNLSCRVVGVPYQGNATA-LFILPSEGK--MQQV 278 + + V VPMM+ +++Y + + V+ +PY+G + + L + P E + + Sbjct: 183 TVNGSAVSVPMMTTTQKFNYGEFVSKDGVDYDVIEMPYEGESISMLLVTPFEKDVPLSAL 242 Query: 279 ENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFT-SHADLSGIS 337 LS + +W + +K +L +P+FS++ L+ L +G+ ++F+ S AD S I+ Sbjct: 243 NKELSSSRIHQWRQEMRKISKQLSIPRFSMDTEIDLKSTLSRMGLGDIFSQSRADFSRIT 302 Query: 338 NHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFI---VD 394 + VS+++ + +EV+E GT+ ++AT + +R+ + + +RPF I Sbjct: 303 TEEPLCVSKVLQRVKLEVNEEGTKGSSATAAVIY---SRMAVEEITLDRPFFFLIQHKPT 359 Query: 395 NNILFLGKVNRP 406 +LF G++ +P Sbjct: 360 GALLFSGQLTQP 371 >1C8O-A nrPDB Length = 300 Score = 134 bits (337), Expect = 8e-32, Method: Compositional matrix adjust. Identities = 99/325 (30%), Positives = 160/325 (49%), Gaps = 32/325 (9%) Query: 51 DLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRG 110 D++R +AS+ +++F SP SIS L +L GA ST Q L K EKE + Sbjct: 2 DIFREIASSMKGENVFISPPSISSVLTILYYGANGSTAEQ--------LSKYVEKEADKN 53 Query: 111 FQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPT-NFRDSAGAM 169 +D N ++ +D+F+ + D F T +F DS + Sbjct: 54 -----------KDDISFKSMNKVYGRYSAVFKDSFLRK-----IGDNFQTVDFTDSR-TV 96 Query: 170 KQINDYVAKQTKGKIVDLLKN-LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSE 228 IN V T+GKI LL L + ++ ++ ++FKAKW F + T + FYV+ Sbjct: 97 DAINKSVDIFTEGKINPLLDEPLSPDTSLLAISAVYFKAKWLMPFEKEFTSDYPFYVSPT 156 Query: 229 TVVRVPMMSR--EDQYHYLLDRNL-SCRVVGVPYQGNATALFILPSE-GKMQQVENGLSE 284 +V V MMS E H + + + ++ +PY G+ + + ILP ++ +E L++ Sbjct: 157 EMVDVSMMSMYGEAFNHASVKESFGNFSIIELPYVGDTSMVVILPDNIDGLESIEQNLTD 216 Query: 285 KTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQV 344 +KW +++++PKF + GSY L L LG++ VF S D S +SN S++ V Sbjct: 217 TNFKKWSDSMDAMFIDVHIPKFKVTGSYNLVDALVKLGLTEVFGSTGDYSNMSN-SDVSV 275 Query: 345 SEMVHKAVVEVDESGTRAAAATGTI 369 M+HK ++V+E T AAAAT + Sbjct: 276 DAMIHKTYIDVNEEYTEAAAATSAL 300 >5NCU-A nrPDB Length = 336 Score = 133 bits (334), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 94/326 (28%), Positives = 160/326 (49%), Gaps = 15/326 (4%) Query: 48 FTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGL---GLNLQKSSE 104 F FDL + ++F SP+S+SM+L M GA T ++ L G ++ +E Sbjct: 14 FAFDLLQTTRKHVTEANVFISPLSVSMALNMTLNGAAGVTADEMKTALRETGYTMEDINE 73 Query: 105 KELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRD 164 L + L + + + N+++ +++ F+ A +T Y A+ +F Sbjct: 74 YS-----HSLREALLKVDPSTTIGMANSIWYKQGELVKEPFILANRTHYDAEVKAVDF-S 127 Query: 165 SAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFY 224 S + IN + A++T KI +L + NA + ++N ++FK W T F T+ F Sbjct: 128 SPATLPAINGWCAQKTNDKITKILDYIPGNAFMYLINAVYFKGIWVTQFKKSDTKRAPFR 187 Query: 225 VTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFI-LPSEGK-MQQVENGL 282 T V MM+++ + Y D C+ + + Y A ++ + LP+EG+ + V L Sbjct: 188 KADGTTQEVNMMAQKSTFGYTTDE--CCQYLEMDYGNKAFSMIVMLPNEGQTTRDVIEQL 245 Query: 283 SEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLE-KVLPSLGISNVFTSHADLSGISNHSN 341 K +K + Q+ L +P+F E Y LE K+LP +G++ FT AD GI++ + Sbjct: 246 DNKHWSMIIKGIRPTQVSLRMPRFKTECKYGLEKKILPEMGMNVPFTETADFPGITDAA- 304 Query: 342 IQVSEMVHKAVVEVDESGTRAAAATG 367 I +S ++HK V+VDE GT AAA T Sbjct: 305 IFISRVIHKTFVQVDEEGTEAAAVTA 330 >2R9Y-A nrPDB Length = 430 Score = 126 bits (316), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 99/365 (27%), Positives = 172/365 (47%), Gaps = 23/365 (6%) Query: 48 FTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKEL 107 FT DL+ +A + S ++ SP+S++++L+ L+LGA + T + L +N Sbjct: 28 FTTDLFSLVAQTSTSSNLVLSPLSVALALSHLALGAQNQTLHSLHRVLHMNTGSC----- 82 Query: 108 HRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAG 167 LL Q + L ++ ++D F+ + L+ A + Sbjct: 83 ---LPHLLSHFYQNLGPGTIRLAARIYLQKGFPIKDDFLEQSERLFGAKPVKLTGKQEED 139 Query: 168 AMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTS 227 + IN +V + T+GKI D L L + V++++N I F W T F+ TQ+ F++ Sbjct: 140 -LANINQWVKEATEGKIEDFLSELPDSTVLLLLNAIHFHGFWRTKFDPSLTQKDFFHLDE 198 Query: 228 ETVVRVPMM-SREDQYHYLLDRNLSCRVVGVPYQGNATALFILPS--EGKMQQVENGLSE 284 V V MM + + L +V P++ N + + ++P+ E + +V L+ Sbjct: 199 RFTVSVDMMHAVSYPLRWFLLEQPEIQVAHFPFKNNMSFVVVMPTYFEWNVSEVLANLTW 258 Query: 285 KTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQV 344 TL + ++R +++LPK ++ L L LG+ +F DL GIS N+ V Sbjct: 259 DTL--YHPSLQERPTKVWLPKLHLQQQLDLVATLSQLGLQELFQG-PDLRGISEQ-NLVV 314 Query: 345 SEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNNI---LFLG 401 S + H++ +E+ E+G AAAAT R++ NRPFL FI+++ I LF+G Sbjct: 315 SSVQHQSTMELSEAGVEAAAATSVAMN----RMSLSSFTVNRPFLFFIMEDTIGVPLFVG 370 Query: 402 KVNRP 406 V P Sbjct: 371 SVRNP 375 >6CJ7-A nrPDB Length = 390 Score = 126 bits (316), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 106/368 (28%), Positives = 181/368 (49%), Gaps = 16/368 (4%) Query: 48 FTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKEL 107 F ++++ +A+ S ++ SP SI++ LAML GA +T +I L + +KS+E Sbjct: 20 FGVNVFKQMATEQ-SGNLAASPFSITILLAMLQQGAAGNTLDEITRALQMTPEKSAEI-- 76 Query: 108 HRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAG 167 F+++ +E+ + L N +F +L F + +D PT F A Sbjct: 77 ---FKKVNEEIQKRNSRNILKTANNVFLSENFNLNPQFKRIAVNNFDSDLTPTYFGKPAL 133 Query: 168 AMKQINDYVAKQTKGKIVDLLK--NLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYV 225 A + IN ++A +T KI L+ +L N ++MVN ++FK WE F + TQ+++F + Sbjct: 134 AAQNINSWIASKTNDKIDKLVSPDDLSGNTQMVMVNAVYFKGLWEIPFREQATQKRNFTL 193 Query: 226 TSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFI-LP-SEGKMQQVENGLS 283 M + + +VV +P++ N +L + LP + + + LS Sbjct: 194 NGGEKKVASFMQTRRYFKAGTHKPAMAKVVVLPFEYNEYSLIVVLPLKSSNVDALLSSLS 253 Query: 284 EKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNI- 342 + + +L + + + L LPKFSI+ LE VL +G+S++FT A+L + +H ++ Sbjct: 254 MEDVASFLDL-PPKDVALELPKFSIKADINLEPVLNKMGVSSIFTQQAELYNLGSHGSLS 312 Query: 343 -QVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNN---IL 398 QVS +H AV+ +DE G AAAAT S S N+PFL + DN L Sbjct: 313 PQVSSALHSAVLTIDERGGSAAAATSFAAVALSYDEPSLYFRANKPFLAILWDNRSSIPL 372 Query: 399 FLGKVNRP 406 F+ ++ P Sbjct: 373 FMARIMDP 380 >1JJO-C nrPDB Length = 261 Score = 125 bits (313), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 69/255 (27%), Positives = 140/255 (54%), Gaps = 10/255 (3%) Query: 125 FQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKI 184 + + L N+LF + + F+ +K + A+ +F + IN +V T + Sbjct: 4 YVMKLANSLFVQNGFHVNEEFLQMLKMYFNAEVNHVDFSQNVAVANSINKWVENYTNSLL 63 Query: 185 VDLLKNLDSNAV--VIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQY 242 DL+ D + V + ++N ++FK W++ F + T+ F E+ V++PMM ++ ++ Sbjct: 64 KDLVSPEDFDGVTNLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEF 123 Query: 243 HYLLDRNLS------CRVVGVPYQGNATALFILPS--EGKMQQVENGLSEKTLRKWLKMF 294 +Y + S +V+ +PY+G+ ++ + S E + +E L + + +W Sbjct: 124 YYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLALSRQEVPLATLEPLLKAQLIEEWANSV 183 Query: 295 KKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVE 354 KK+++E+YLP+F++E L+ +L +LG++ +F A+L+ +S+ + +S+ VHK+ +E Sbjct: 184 KKQKVEVYLPRFTVEQEIDLKDILKALGVTEIFIKDANLTAMSDKKELFLSKAVHKSCIE 243 Query: 355 VDESGTRAAAATGTI 369 V+E G+ AAAA+G I Sbjct: 244 VNEEGSEAAAASGMI 258 >3LE2-A nrPDB Length = 393 Score = 123 bits (309), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 104/382 (27%), Positives = 183/382 (47%), Gaps = 45/382 (11%) Query: 56 LASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLL 115 + + + + ++ FSP SI++ L++++ G+ +TK QIL L SS +L+ +++ Sbjct: 24 ITTVSQNSNVIFSPASINVVLSIIAAGSAGATKDQILSFLKF----SSTDQLNSFSSEIV 79 Query: 116 QEL---NQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSA-GAMKQ 171 + G +LS+ N + D + + +F ++ Y A + +F+ A + + Sbjct: 80 SAVLADGSANGGPKLSVANGAWIDKSLSFKPSFKQLLEDSYKAASNQADFQSKAVEVIAE 139 Query: 172 INDYVAKQTKGKIVDLLK--NLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSET 229 +N + K+T G I ++L + DS +I N ++FK W F+ TQE +F++ Sbjct: 140 VNSWAEKETNGLITEVLPEGSADSMTKLIFANALYFKGTWNEKFDESLTQEGEFHLLDGN 199 Query: 230 VVRVPMM-SREDQYHYLLDRNLSCRVVGVPY-QGNA----TALFILPSEGKMQQVENGLS 283 V P M S++ QY D +V+G+PY QG + F LP NGLS Sbjct: 200 KVTAPFMTSKKKQYVSAYD---GFKVLGLPYLQGQDKRQFSMYFYLP------DANNGLS 250 Query: 284 EKTLRKWLKM-------FKKRQL---ELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADL 333 + L K + +RQ+ E +PKF + VL LG+++ F+ L Sbjct: 251 D-LLDKIVSTPGFLDNHIPRRQVKVREFKIPKFKFSFGFDASNVLKGLGLTSPFSGEEGL 309 Query: 334 SGISNH----SNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVF--NRP 387 + + N+ VS + HKA +EV+E GT AAAA+ + R + + F + P Sbjct: 310 TEMVESPEMGKNLCVSNIFHKACIEVNEEGTEAAAASAGVIKLRGLLMEEDEIDFVADHP 369 Query: 388 FLMFIVDN---NILFLGKVNRP 406 FL+ + +N +LF+G+V P Sbjct: 370 FLLVVTENITGVVLFIGQVVDP 391 >2PEF-A nrPDB Length = 373 Score = 123 bits (309), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 106/373 (28%), Positives = 186/373 (49%), Gaps = 34/373 (9%) Query: 47 DFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKE 106 DF+ +L++ S ++ SP+S ++LAM + GA + T Q+ + LG ++ S ++ Sbjct: 15 DFSIELFKN--SIDDKENSLISPLSAMLALAMTANGADNETLAQMEKALGKDI---SIED 69 Query: 107 LHRGFQQLLQEL-NQPRDGFQLSLGNALF---TDLVVDLQDTFVSAMKTLYLADTFPTNF 162 L++ +++L N+ + +L++ N+++ D + F+ + Y AD F F Sbjct: 70 LNKYLYTYMKKLPNEEKS--KLTIANSIWFKENDFMP--SKDFLQIIADYYKADIFKAAF 125 Query: 163 RDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQD 222 S + IN++V +T G I +L +D V+ ++N + F A+WET + E Sbjct: 126 DSST--VSDINNWVKSKTNGMIDKILNKIDPEDVMYLINAVAFDAEWETVYEKASVHEDI 183 Query: 223 FYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGV--PYQGNATALF-ILPSEGKMQQVE 279 F +V M+ E+ Y+ + N VG PY N + ILP E V Sbjct: 184 FTDVYGNRQKVEFMNSEENL-YIEEEN----AVGFVKPYAKNHYSFVAILPDEN--ISVN 236 Query: 280 NGLSEKTLRKWLKMFKKRQLELY---LPKFSIEGSYQLEKVLPSLGISNVF-TSHADLS- 334 + T +K++ + K ++ L LPKF E + ++ + L SLG+++ F AD S Sbjct: 237 EYIKTLTGQKFIDLIKNAKITLVRASLPKFKYEYTIKMNETLESLGMTDAFLPDKADFSK 296 Query: 335 -GISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIV 393 G S+ N+ +SE++HK + VDE GT+A A T T +N + + NRPF+ I+ Sbjct: 297 LGKSDIGNLYISEVLHKTFISVDELGTKAGAVTSVDITAAGIPVNFKTVKLNRPFIFAII 356 Query: 394 DNNI---LFLGKV 403 DN+ +F+G V Sbjct: 357 DNSTNLPIFIGTV 369 >3PZF-A nrPDB Length = 397 Score = 122 bits (307), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 92/360 (25%), Positives = 169/360 (46%), Gaps = 21/360 (5%) Query: 64 SIFFSPVSISMSLAML------SLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLLQE 117 ++ SP S+ + L ++ S G S + L + +Q + ++QLL+ Sbjct: 40 NVVLSPFSVKILLTLIYEASDTSFGNAVSNTKRELSSV---IQNDNIDHTRSYYKQLLES 96 Query: 118 LNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVA 177 Q + L++ F D +++ + + T Y A ++ + IN++V+ Sbjct: 97 AQQDNKDYDLNIATNFFVDDFIEVINKYQQIANTHYHAMLEKVSYSNPTQTAATINNWVS 156 Query: 178 KQTKGKIVDLLKNLDS--NAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPM 235 + T G++ +++ DS AV+ +VN I+FK W F + FY T Sbjct: 157 EHTNGRLREIVT-PDSLEGAVITLVNVIYFKGLWTYPFPEVANNVKPFYGTRGKPTNAQY 215 Query: 236 MSREDQYHYLLDRNLSCRVVGVPYQGNATAL-FILPS-EGKMQQVENGLSEKTLRKWLKM 293 M + Q++Y +L +++ +PY+GN A+ FILP+ + + QV + ++ +L + L Sbjct: 216 MEQNGQFYYDNSADLGAQILRLPYRGNKLAMYFILPNPDNTVNQVLDRINSASLHQALWY 275 Query: 294 FKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLS----GISNHSNIQVSEMVH 349 ++ ++ + LPKF + S QL + L +GI +F+ +A L G ++VS + Sbjct: 276 MEENEVNVTLPKFKFDFSEQLNEPLQQVGIREIFSQNASLPLLARGRGARDEVRVSRIFQ 335 Query: 350 KAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNNI---LFLGKVNRP 406 KA + ++E G+ A AAT + Q NRPF+ FI D + LF GK+ P Sbjct: 336 KAGITINELGSEAYAATEIQLVNKFGGDGVQIFNANRPFIFFIEDETLGTMLFAGKIENP 395 >1SEK-A nrPDB Length = 378 Score = 117 bits (294), Expect = 7e-27, Method: Compositional matrix adjust. Identities = 78/296 (26%), Positives = 148/296 (50%), Gaps = 16/296 (5%) Query: 44 SRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGL---NLQ 100 S FT ++ + A P Q++ S S+ L L+L + + ++L L L N+ Sbjct: 14 SNDQFTAQMFSEVVKANPGQNVVLSAFSVLPPLGQLALASVGESHDELLRALALPNDNVT 73 Query: 101 KSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPT 160 K +L+RG + + G L + + ++ ++L D F + + ++ ++ Sbjct: 74 KDVFADLNRGVRAV--------KGVDLKMASKIYVAKGLELNDDFAAVSRDVFGSEVQNV 125 Query: 161 NFRDSAGAMKQINDYVAKQTKGKIVDLLK--NLDSNAVVIMVNYIFFKAKWETSFNHKGT 218 +F S A IN +V QT +I +L+ LD ++VN I+FK W+ FN + T Sbjct: 126 DFVKSVEAAGAINKWVEDQTNNRIKNLVDPDALDETTRSVLVNAIYFKGSWKDKFNKERT 185 Query: 219 QEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGN-ATALFILPSE-GKMQ 276 ++DF+V+ + ++VP M + Y L +++ + Y+G+ A+ + ILP++ + Sbjct: 186 MDRDFHVSKDKTIKVPTMIGKKDVRYADVPELDAKMIEMSYEGDQASMIIILPNQVDGIT 245 Query: 277 QVENGLSE-KTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHA 331 +E L + K L + + ++E+YLPKF IE + L++VL ++ I +FT A Sbjct: 246 ALEQKLKDPKALSRAEERLYNTEVEIYLPKFKIETTTDLKEVLSNMNIKKLFTPGA 301 >2OAY-A nrPDB Length = 390 Score = 114 bits (286), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 104/373 (27%), Positives = 194/373 (52%), Gaps = 35/373 (9%) Query: 47 DFTFDLYRALASAAPSQS-IFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEK 105 DF+ LY A ++ ++ + FSP SI+ L + LGAG +TK + L + Sbjct: 38 DFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDFTCVH 97 Query: 106 ELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDS 165 + +GF G ++ + +F + ++DTFV+A +TLY + P ++ Sbjct: 98 QALKGFTT---------KG--VTSVSQIFHSPDLAIRDTFVNASRTLYSSS--PRVLSNN 144 Query: 166 AGA-MKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFY 224 + A ++ IN +VAK T KI LL +L S+ ++++N I+ AKW+T+F+ K T+ + F+ Sbjct: 145 SDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWKTTFDPKKTRMEPFH 204 Query: 225 VTSETVVRVPMM-SREDQYHYLLDRNLSCRVVGVPYQGNATALFILPS--EGKMQQVENG 281 + +V++VPMM S++ + +D+ L +V + N + + ++P + +++ +E Sbjct: 205 FKN-SVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLKHRLEDMEQA 263 Query: 282 LSE---KTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISN 338 LS K + + L+M K + L LP+ + S + ++ L + F+ +L G++ Sbjct: 264 LSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFD-FSYDLNLCGLTE 322 Query: 339 HSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFN--RPFLMFIVDNN 396 ++QVS M H+ V+E+ E+G AAAA+ + + LVF +PFL + D Sbjct: 323 DPDLQVSAMQHQTVLELTETGVEAAAAS-------AISVARTLLVFEVQQPFLFMLWDQQ 375 Query: 397 ---ILFLGKVNRP 406 +F+G+V P Sbjct: 376 HKFPVFMGRVYDP 388 >1M93-B nrPDB Length = 245 Score = 112 bits (280), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 73/222 (32%), Positives = 119/222 (53%), Gaps = 8/222 (3%) Query: 154 LADTFPT-NFRDSAGAMKQINDYVAKQTKGKIVDLLKN-LDSNAVVIMVNYIFFKAKWET 211 + D F T +F DS + IN V T+GKI LL L + ++ ++ ++FKAKW Sbjct: 26 IGDNFQTVDFTDSR-TVDAINKSVDIFTEGKINPLLDEPLSPDTSLLAISAVYFKAKWLM 84 Query: 212 SFNHKGTQEQDFYVTSETVVRVPMMSR--EDQYHYLLDRNL-SCRVVGVPYQGNATALFI 268 F + T + FYV+ +V V MMS E H + + + ++ +PY G+ + + I Sbjct: 85 PFEKEFTSDYPFYVSPTEMVDVSMMSMYGEAFNHASVKESFGNFSIIELPYVGDTSMVVI 144 Query: 269 LPSE-GKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVF 327 LP ++ +E L++ +KW +++++PKF + GSY L L LG++ VF Sbjct: 145 LPDNIDGLESIEQNLTDTNFKKWSDSMDAMFIDVHIPKFKVTGSYNLVDALVKLGLTEVF 204 Query: 328 TSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTI 369 S D S +SN S++ V M+HK ++V+E T AAAAT + Sbjct: 205 GSTGDYSNMSN-SDVSVDAMIHKTYIDVNEEYTEAAAATSAL 245 >3OZQ-A nrPDB Length = 376 Score = 111 bits (277), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 102/373 (27%), Positives = 187/373 (50%), Gaps = 23/373 (6%) Query: 42 PSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQK 101 P++ FT +Y+ + + + SP S + LA+ G T +I + L Sbjct: 12 PNAVNSFTPSVYKEVLKTEKA-NFLVSPFSAATLLALAQSGCRGDTAEEIRQVLHF---- 66 Query: 102 SSEKELHRG-FQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPT 160 ++E G +++L +L + + L N ++ +++ F +Y A + Sbjct: 67 VGDREKAEGAVKEVLSKLT--NEEYTLHTANKIYVKTNFSVREEFQKIAVEVYGAQSENV 124 Query: 161 NFRDSAGAMKQINDYVAKQTKGKIVDLL--KNLDSNAVVIMVNYIFFKAKWETSFNHKGT 218 +F + A K +N +V +QT+ KI +L+ + L++ V+++N ++F AKW F T Sbjct: 125 DFSEKNDAAKLMNAWVEEQTQHKIQNLVDPEILNNLTRVVLINALYFNAKWLVPFPPFHT 184 Query: 219 QEQDFYVTSETVVRVPMMSREDQY-HYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQ 277 ++ DF+ +++ VV+V M ++QY +Y +L +++ +P++G A+ +L + Q Sbjct: 185 RKSDFHKSAKEVVQVDTMYLDEQYFNYYECHHLDAKLLELPFKGGASLTIVLSN-----Q 239 Query: 278 VEN--GLSEKTLRKWLKMFKKRQL-ELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLS 334 +E L K R +L +QL + LPKF IE + +KVL LG+ F ADLS Sbjct: 240 IEGLVSLESKIKRSFLPHNLTKQLVNVALPKFKIESTVDFKKVLKKLGVKKAFGDEADLS 299 Query: 335 GISNH-SNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARL--NSQRLVFNRPFLMF 391 GI+ ++ +S +V K+ ++V E G AAAAT L + ++ + + PF+ + Sbjct: 300 GIAGEKGDLVISNIVQKSFIDVSEEGVEAAAATYIPVILPEMALPDSPKQFIVDHPFIFY 359 Query: 392 I-VDNNILFLGKV 403 I V ILF G+V Sbjct: 360 IKVKGMILFAGRV 372 >3STO-A nrPDB Length = 406 Score = 111 bits (277), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 94/374 (25%), Positives = 172/374 (45%), Gaps = 25/374 (6%) Query: 43 SSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAML--SLGAGSSTKMQILEGLGLNLQ 100 SS + FT + + + P+ I +L +L S GA T QI + + L Sbjct: 17 SSHKAFTHAYLSTVTADFGGDNFLTCPLGILFTLGILLGSGGAQGRTGYQIGKTMRLKST 76 Query: 101 KSSEK--ELHRGFQQLLQELNQP----------RDGFQLSLGNALFTDLVVDLQDTFVSA 148 SS E + + L QELN ++ + + +F + +++ F + Sbjct: 77 SSSWNSSEAQQEMKSLYQELNNSLTSEKTFLNEKEENVVRISTGIFVEKTYEVERRFNES 136 Query: 149 MKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLL-KNLDSNAVVIMVNYIFFKA 207 + + +F + A IND+V +Q+ G + ++ + +I+VN +F+ Sbjct: 137 IANDSEGELKQVDFSNRTSATVDINDWVDQQSNGLLEKFFTDDIPDDTAMILVNVFYFRD 196 Query: 208 KWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNA-TAL 266 W++ F T+++DFY++ + + V MM++E Y + +V P T + Sbjct: 197 FWQSPFEPHYTRKEDFYISPDRQITVDMMTQEGVMKYGKFEDEGFEIVSKPLNNTRFTFV 256 Query: 267 FILPSEGKMQQVENGLSE-----KTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSL 321 +LP E + NG +E K L +++K K+ + L LPKF+++ + L L S+ Sbjct: 257 IVLPLE---KWSLNGATELLNGNKVLSEYVKNLKETTVSLRLPKFTLKNTLDLVPTLKSI 313 Query: 322 GISNVFTS-HADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQ 380 G+ ++F +DLSGI+ + N+ V+E + V++++ESG A T IF SA + Sbjct: 314 GVVDLFDPVKSDLSGITPNPNLYVNEFIQTNVLKLNESGIEATTVTSPIFVPFSAIIPEV 373 Query: 381 RLVFNRPFLMFIVD 394 PF+ FI D Sbjct: 374 DFHVTHPFICFIYD 387 >1K9O-I nrPDB Length = 378 Score = 111 bits (277), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 76/296 (25%), Positives = 146/296 (49%), Gaps = 16/296 (5%) Query: 44 SRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGL---NLQ 100 S FT ++ + A P Q++ S S+ L L+L + + ++L L L N+ Sbjct: 14 SNDQFTAQMFSEVVKANPGQNVVLSAFSVLPPLGQLALASVGESHDELLRALALPNDNVT 73 Query: 101 KSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPT 160 K +L+RG + + G L + + ++ ++L D F + + ++ ++ Sbjct: 74 KDVFADLNRGVRAV--------KGVDLKMASKIYVAKGLELNDDFAAVSRDVFGSEVQNV 125 Query: 161 NFRDSAGAMKQINDYVAKQTKGKIVDLLK--NLDSNAVVIMVNYIFFKAKWETSFNHKGT 218 +F S A IN +V QT +I +L+ LD ++VN I+FK W+ F + T Sbjct: 126 DFVKSVEAAGAINKWVEDQTNNRIKNLVDPDALDETTRSVLVNAIYFKGSWKDKFVKERT 185 Query: 219 QEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGN-ATALFILPSE-GKMQ 276 ++DF+V+ + ++VP M + Y L +++ + Y+G+ A+ + ILP++ + Sbjct: 186 MDRDFHVSKDKTIKVPTMIGKKDVRYADVPELDAKMIEMSYEGDQASMIIILPNQVDGIT 245 Query: 277 QVENGLSE-KTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHA 331 +E L + K L + + ++E+ LPKF IE + L++VL ++ I +FT A Sbjct: 246 ALEQKLKDPKALSRAEERLYNTEVEITLPKFKIETTTDLKEVLSNMNIKKLFTPGA 301 >1SNG-A nrPDB Length = 370 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 101/367 (27%), Positives = 162/367 (44%), Gaps = 26/367 (7%) Query: 47 DFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKE 106 +F L+R LA A P + +SP S++ +L +L+ GA ++T+ ++ LG + Sbjct: 16 EFALHLHRRLAEAVPDGEVIWSPYSVACALGVLAAGARATTRTELTTLLGTDPAP----- 70 Query: 107 LHRGFQQLLQELNQP-RDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFR-D 164 LL L++ D L+ L+ V ++ +F + M +D +FR + Sbjct: 71 -------LLAALDRAVTDSPDLASRTVLWVSADVPVRSSFRATMHDRPDSDVRTADFRTN 123 Query: 165 SAGAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQD 222 G +N +A T+G I +LL + + I+ N ++ KA+W T F T+ Sbjct: 124 PEGVRATVNADIADATRGMIRELLPQGAVTPDLRAILTNALWAKARWTTPFEAHLTRAGT 183 Query: 223 FYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGL 282 F T RVP M R Y R R+V + +LP V Sbjct: 184 FR-TPRGPKRVPFMHRTKTMPYATARG--WRMVTLHAHDELAVDVLLPPGTNAAAVPTA- 239 Query: 283 SEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNI 342 L + +EL LP+F + +QL +VL G+ +FT+ ADLSGIS + Sbjct: 240 --PLLTALHRRSASTSVELALPRFELTQPHQLVEVLAEAGVRTLFTASADLSGIST-VPL 296 Query: 343 QVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVF--NRPFLMFIVDNN-ILF 399 V ++H+A + VDE G AAAT + A + + F +RPF + + ILF Sbjct: 297 YVDTVIHQARLRVDERGAEGAAATAAMMLLAGAMPPRRTIRFSVDRPFHIVVRRRGAILF 356 Query: 400 LGKVNRP 406 LG + P Sbjct: 357 LGSIADP 363 >6BJ5-B nrPDB Length = 315 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 78/311 (25%), Positives = 146/311 (46%), Gaps = 32/311 (10%) Query: 62 SQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLLQELNQP 121 S ++ FSP ++ +L++L + AG +TK +I + + + + Sbjct: 30 SDNVVFSPYGLTSALSVLRIAAGGNTKREI---------------------DVPESVVED 68 Query: 122 RDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTK 181 D F L+L LF D V L+ F + + + F +S IN YV +T Sbjct: 69 SDAF-LAL-RELFVDASVPLRPEFTAEFSSRFNTSVQRVTF-NSENVKDVINSYVKDKTG 125 Query: 182 GKIVDLLK-NLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSRED 240 G + +L +LD + +++++ + K W F+ T +Q FY + +V MM++ D Sbjct: 126 GDVPRVLDASLDRDTKMLLLSSVRMKTSWRHVFDPSFTTDQPFY-SGNVTYKVRMMNKID 184 Query: 241 --QYHYLLDRNLSCRVVGVPYQGNATA-LFILPSEGKMQQVENGLSEKTLRKWLKMFKKR 297 + RN+ V +PY+ TA L ++P + + ++ L +R W++ +K Sbjct: 185 TLKTETFTLRNVGYSVTELPYKRRQTAMLLVVPDD--LGEIVRALDLSLVRFWIRNMRKD 242 Query: 298 QLELYLPKFSIEGSYQLEKVLPSLGISNVFT-SHADLSGISNHSNIQVSEMVHKAVVEVD 356 ++ +PKFS+E L L LG+ + F S AD S +++ V++++ + +E D Sbjct: 243 VCQVVMPKFSVESVLDLRDALQRLGVRDAFDPSRADFGQASPSNDLYVTKVLQTSKIEAD 302 Query: 357 ESGTRAAAATG 367 E GT A++ T Sbjct: 303 ERGTTASSDTA 313 >1MTP-A nrPDB Length = 323 Score = 94.4 bits (233), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 86/315 (27%), Positives = 140/315 (44%), Gaps = 23/315 (7%) Query: 47 DFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKE 106 +F L+R LA A P + +SP S++ +L +L+ GA ++T+ ++ LG + Sbjct: 12 EFALHLHRRLAEAVPDGEVIWSPYSVACALGVLAAGARATTRTELTTLLGTDPAP----- 66 Query: 107 LHRGFQQLLQELNQP-RDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFR-D 164 LL L++ D L+ L+ V ++ +F + M +D +FR + Sbjct: 67 -------LLAALDRAVTDSPDLASRTVLWVSADVPVRSSFRATMHDRPDSDVRTADFRTN 119 Query: 165 SAGAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQD 222 G +N +A T+G I +LL + + I+ N ++ KA+W T F T+E Sbjct: 120 PEGVRATVNADIADATRGMIRELLPQGAVTPDLRAILTNALWAKARWTTPFEAHLTREGT 179 Query: 223 FYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGL 282 F T RVP M R Y R R+V + +LP V Sbjct: 180 FR-TPRGPKRVPFMHRTKTMPYATARG--WRMVTLHAHDELAVDVLLPPGTNAAAVPTAP 236 Query: 283 SEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNI 342 L + +EL LP+F + +QL +VL G+ +FT+ ADLSGIS + Sbjct: 237 LLTALHR---RSASTSVELALPRFELTQPHQLVEVLAEAGVRTLFTASADLSGIST-VPL 292 Query: 343 QVSEMVHKAVVEVDE 357 V ++H+A + VDE Sbjct: 293 YVDTVIHQARLRVDE 307 >5M3Y-A nrPDB Length = 458 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 89/364 (24%), Positives = 156/364 (42%), Gaps = 40/364 (10%) Query: 67 FSPVSISMSLAMLSLGAGSSTKMQILEGLGL---NLQKSSEKELHR------GFQQLLQE 117 SP ++ +LA L LGA T ++ LG+ + Q +S + H+ Q LL Sbjct: 101 LSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKQCTSRLDAHKVLSALQAVQGLLVA 160 Query: 118 LNQPRDGFQLSLGN--ALFTDLVVDLQDTFVSAMKTLYLADTFPT--NFRDSAGAMKQIN 173 + QL L +FT + L+ FV + LY P +F + A ++I+ Sbjct: 161 QGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGL-ALYTPVVLPRSLDFTELDVAAEKID 219 Query: 174 DYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKG----TQEQDFYVTSET 229 ++ T K L ++ + Y+ F+ K KG + Q+F+V T Sbjct: 220 RFMQAVTGWKTGSSLMGASVDSTLAFNTYVHFQGK------MKGFSLLAEPQEFWVDQST 273 Query: 230 VVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPS-EGKMQQVENGLSEKTLR 288 V VPM+S + + D V VP+ +A+ L I P + +VE ++ Sbjct: 274 SVSVPMLSGMGTFQHWSDIQDQFSVTQVPFTESASLLLIQPHYASDLDKVEGLTFQQNSL 333 Query: 289 KWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMV 348 W+K R + L +P+ ++GSY L+ +L + + + +L +SN I+V E++ Sbjct: 334 NWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSN-DRIRVGEVL 392 Query: 349 HKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLV---FNRPFLMFIVDNN---ILFLGK 402 + E++ +T +LN ++ NRPFL + D + + FLG+ Sbjct: 393 NSIFFELEADEREPTEST--------QQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGR 444 Query: 403 VNRP 406 V P Sbjct: 445 VANP 448 >2WXZ-C nrPDB Length = 453 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 73/286 (25%), Positives = 128/286 (44%), Gaps = 23/286 (8%) Query: 132 ALFTDLVVDLQDTFVSAMKTLYLADTFPTNF---RDSAGAMKQINDYVAKQTKGKIVDLL 188 LFT + L+ FV ++ A FP + D A ++IN +V T K+ L Sbjct: 176 GLFTAPGLRLKQPFVESLGPFTPA-IFPRSLDLSTDPVLAAQKINRFVQAVTGWKMNLPL 234 Query: 189 KNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDR 248 + + +++ + Y+ F+ K G E F+V + T V VPM+S + + D Sbjct: 235 EGVSTDSTLFFNTYVHFQGKMRGFSQLTGLHE--FWVDNSTSVSVPMLSGTGNFQHWSDA 292 Query: 249 NLSCRVVGVPYQGNATALFILP-SEGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFS 307 + V VP + T L I P + +VE + + W+K R + L LP+ Sbjct: 293 QNNFSVTRVPLGESVTLLLIQPQCASDLDRVEVLVFQHDFLTWIKNPPPRAIRLTLPQLE 352 Query: 308 IEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEV----DESGTRAA 363 I GSY L+ +L +S + + A+L G +N +V E+++ ++E+ +E T +A Sbjct: 353 IRGSYNLQDLLAQAKLSTLLGAEANL-GKMGDTNPRVGEVLNSILLELQAGEEEQPTESA 411 Query: 364 AATGTIFTFRSARLNSQRLVFNRPFLMFIVDNN---ILFLGKVNRP 406 G+ + + PFL I + + + FLG+V+ P Sbjct: 412 QQPGSPEVL--------DVTLSSPFLFAIYERDSGALHFLGRVDNP 449 >2WXX-A nrPDB Length = 453 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 70/282 (24%), Positives = 129/282 (45%), Gaps = 15/282 (5%) Query: 132 ALFTDLVVDLQDTFVSAMKTLYLADTFPTNF---RDSAGAMKQINDYVAKQTKGKIVDLL 188 LFT L+ +FV ++ L+ FP + D A ++IN ++ T K+ L Sbjct: 176 GLFTAPGFRLKHSFVQSL-ALFTPALFPRSLDLSTDPVLATEKINRFIKAVTGWKMNLPL 234 Query: 189 KNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDR 248 + + +++ ++ Y+ F+ G E F+V + V VPM+S + + D Sbjct: 235 EGVSTDSTLLFNTYVHFQGTMRGFSQLPGVHE--FWVDNSISVSVPMISGTGNFQHWSDA 292 Query: 249 NLSCRVVGVPYQGNATALFILP-SEGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFS 307 + V VP AT L I P + +VE + + L W++ R + L LP+ Sbjct: 293 QNNFSVTCVPLGERATLLLIQPHCISDLDRVEALIFQNDLLTWIENPPPRAIRLTLPQLE 352 Query: 308 IEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATG 367 I GSY L+ +L + + + A+L+ I + +N +V E+++ ++E+ ++G T Sbjct: 353 IRGSYNLQDLLAEDKLPTLLGAEANLNNIGD-TNPRVGEVLNSILLEL-KAGEEEQPTTS 410 Query: 368 TIFTFRSARLNSQRLVFNRPFLMFIVDNN---ILFLGKVNRP 406 L+ + + PFL I + + + FLG+VN P Sbjct: 411 VQQPGSPEALD---VTLSSPFLFAIYEQDSGTLHFLGRVNNP 449 >5C98-A nrPDB Length = 382 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 81/383 (21%), Positives = 159/383 (41%), Gaps = 39/383 (10%) Query: 38 ATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTK--MQILEGL 95 A VA +++ FT + ++A + ++ SP + ++L+M AG++ + Q+ GL Sbjct: 16 AIVAANNK--FTLEYFKACYDEKCNCAV--SPYHVRLALSMFYPLAGAAVQEDFQVAFGL 71 Query: 96 GLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLA 155 ++ + E++ Q+L Q+L+ DG L + + + + L F + Sbjct: 72 PEDVHAAIEQQ-----QRLAQQLH---DGQHLKALSFVLVEETLRLDSEFERLFHRTFQT 123 Query: 156 DTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKA-----KWE 210 P + D + +N + ++ +I D + D ++ + F Sbjct: 124 TVEPVDLTDDIPSALAVNSFY-QRANTEIEDFIGEGDVFSLPPCHKLMLFSGVSVLTPLA 182 Query: 211 TSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNA--TALFI 268 FN T + F + RV M L L C+VV +P+ + + L + Sbjct: 183 IRFNPADTALELFQFINAPTQRVSTMHTTAFVRRCLHNELRCKVVDMPFDAASGLSMLVL 242 Query: 269 LPSEG-KMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVF 327 LP +G +++Q+ N ++ L + + + +L LPKF + ++ L LG VF Sbjct: 243 LPYDGTELRQIVNSITPAHLAQIDERLQSCWTDLKLPKFFVREKTDPKQTLGKLGYGGVF 302 Query: 328 TSHADLSGISNHSNIQVSEMVHKAVVEVDESGT--RAAAATGTIFTFRSARLNSQRLVFN 385 DL + +++ + + V ESG+ A T + F F + N Sbjct: 303 EID-DLHVFHDSGRTRLNGFIQHCYLAVSESGSGIPAPPDTPSEFEFHA----------N 351 Query: 386 RPFLMFI---VDNNILFLGKVNR 405 RPF+ I +D N+L +G ++ Sbjct: 352 RPFMFLIRRTMDGNVLQVGNFSK 374 >4B5T-A nrPDB Length = 251 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 17/55 (30%), Positives = 27/55 (49%), Gaps = 4/55 (7%) Query: 309 EGSYQLEKVLPSLGISNVFTSHADLSG----ISNHSNIQVSEMVHKAVVEVDESG 359 E L ++L G+ VF ADLS N + +V + +A+V++ ESG Sbjct: 152 EAMKNLPQILDVEGVDGVFIGPADLSADMGYAGNPQHPEVQAAIEQAIVQIRESG 206 >2V5J-A nrPDB Length = 287 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 17/55 (30%), Positives = 27/55 (49%), Gaps = 4/55 (7%) Query: 309 EGSYQLEKVLPSLGISNVFTSHADLSG----ISNHSNIQVSEMVHKAVVEVDESG 359 E L ++L G+ VF ADLS N + +V + +A+V++ ESG Sbjct: 177 EAMKNLPQILDVEGVDGVFIGPADLSADMGYAGNPQHPEVQAAIEQAIVQIRESG 231 >5LQD-A nrPDB Length = 465 Score = 29.3 bits (64), Expect = 3.1, Method: Compositional matrix adjust. Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 1/46 (2%) Query: 23 HPREMKKRVEDLHVGATVAPSSRRDFTFDLYRALASAAPSQSIFFS 68 HP ++ + E LH T+ P R D T L A A+A P Q F + Sbjct: 413 HPYDVSETAEALHTALTMPPPERADRTKRLASA-ATALPPQRWFLN 457 >4W8Y-A nrPDB Length = 888 Score = 28.5 bits (62), Expect = 4.9, Method: Compositional matrix adjust. Identities = 26/74 (35%), Positives = 36/74 (48%), Gaps = 9/74 (12%) Query: 272 EGKMQQVEN-GLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQ-LEKVLPSLGISNV--- 326 E Q EN GLS++ ++KWLK +K++ L + +I Y L K+L SLG V Sbjct: 396 EDIYQVTENAGLSDEDVKKWLKFAEKKENSRVLERIAI---YPLLVKILDSLGERKVTEE 452 Query: 327 -FTSHADLSGISNH 339 F L G H Sbjct: 453 RFEKSEQLKGWKCH 466 >4QP0-A nrPDB Length = 359 Score = 27.7 bits (60), Expect = 9.1, Method: Compositional matrix adjust. Identities = 13/41 (31%), Positives = 24/41 (58%) Query: 183 KIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDF 223 +I + +K++DSN +V + + FF K E+ + + G DF Sbjct: 201 EISEYIKSIDSNHLVAVGDEGFFNRKGESDYEYNGGSGMDF 241 >2AGK-A nrPDB Length = 260 Score = 27.7 bits (60), Expect = 9.4, Method: Compositional matrix adjust. Identities = 19/72 (26%), Positives = 36/72 (50%), Gaps = 3/72 (4%) Query: 247 DRNL-SCRVVGVPYQGNATALFILPSEGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPK 305 DR++ C V+ + + A L + QV G+++ +WLK K + +L Sbjct: 49 DRDVQGCHVIKLGPNNDDAAREALQESPQFLQVGGGINDTNCLEWLKWASKVIVTSWL-- 106 Query: 306 FSIEGSYQLEKV 317 F+ EG +QL+++ Sbjct: 107 FTKEGHFQLKRL 118 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6EE5-A nrPDB 517 e-147 2OL2-A nrPDB 502 e-143 3NE4-A nrPDB 462 e-131 3DY0-A nrPDB 452 e-127 6HGE-B nrPDB 447 e-126 2VDY-A nrPDB 433 e-122 5HGC-A nrPDB 432 e-121 1YXA-A nrPDB 427 e-120 1BY7-A nrPDB 416 e-117 6F02-A nrPDB 408 e-114 1C5G-A nrPDB 400 e-112 4Y40-A nrPDB 396 e-111 1QMB-A nrPDB 395 e-110 2XN5-A nrPDB 386 e-107 4GA7-A nrPDB 385 e-107 4EB1-I nrPDB 385 e-107 1ATT-A nrPDB 384 e-107 2V95-A nrPDB 379 e-105 4ZK0-A nrPDB 376 e-105 6F4U-A nrPDB 376 e-104 2H4Q-A nrPDB 374 e-104 4AJT-A nrPDB 374 e-104 2H4P-A nrPDB 371 e-103 3LW2-A nrPDB 370 e-103 3NDA-A nrPDB 369 e-102 1UHG-A nrPDB 366 e-101 4KDS-A nrPDB 364 e-101 1HLE-A nrPDB 364 e-101 1JMJ-A nrPDB 363 e-100 4P0F-A nrPDB 359 1e-99 5NCS-A nrPDB 358 4e-99 4DY0-A nrPDB 354 3e-98 5INW-A nrPDB 354 4e-98 4DTE-A nrPDB 354 5e-98 3F02-A nrPDB 353 8e-98 4AJU-A nrPDB 346 1e-95 3ZHA-A nrPDB 333 8e-92 5NCU-A nrPDB 332 2e-91 1XQJ-A nrPDB 321 3e-88 2R9Y-A nrPDB 319 1e-87 1IMV-A nrPDB 310 8e-85 3OZQ-A nrPDB 306 2e-83 6CJ7-A nrPDB 304 4e-83 3PZF-A nrPDB 299 2e-81 3STO-A nrPDB 298 2e-81 1K9O-I nrPDB 294 5e-80 1SEK-A nrPDB 290 7e-79 3LE2-A nrPDB 287 7e-78 1C8O-A nrPDB 286 2e-77 2PEF-A nrPDB 281 4e-76 1SNG-A nrPDB 281 5e-76 1JJO-C nrPDB 278 3e-75 2OAY-A nrPDB 274 6e-74 5M3Y-A nrPDB 259 2e-69 1MTP-A nrPDB 254 7e-68 2WXZ-C nrPDB 252 2e-67 2WXX-A nrPDB 252 2e-67 6BJ5-B nrPDB 239 2e-63 1M93-B nrPDB 239 2e-63 5C98-A nrPDB 237 6e-63 Sequences not found previously or not previously below threshold: 4R9I-A nrPDB 97 1e-20 5NSQ-A nrPDB 31 0.92 4P2L-A nrPDB 31 1.0 3DO6-A nrPDB 30 1.9 3H1Q-A nrPDB 30 2.0 5NSS-F nrPDB 29 2.4 2C98-A nrPDB 29 2.4 3T59-A nrPDB 29 3.7 5U6P-A nrPDB 29 3.9 1F2V-A nrPDB 29 4.4 5W76-A nrPDB 29 5.1 2I0Q-B nrPDB 28 7.6 5MRJ-A nrPDB 28 9.9 >6EE5-A nrPDB Length = 379 Score = 517 bits (1332), Expect = e-147, Method: Composition-based stats. Identities = 187/368 (50%), Positives = 250/368 (67%), Gaps = 13/368 (3%) Query: 42 PSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQK 101 + DF F LYR LA ++P ++IFFSPVSIS +LAMLSLGA T QILEGLG N Sbjct: 22 AEANTDFAFSLYRELAKSSPDKNIFFSPVSISSALAMLSLGAKGDTHTQILEGLGFN--- 78 Query: 102 SSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTN 161 SE ++H+GFQ LLQ LN+P G QL N LF D + L D+F+ K LY A+ F + Sbjct: 79 -SEADIHQGFQHLLQTLNRP-KGLQLKTANGLFVDKSLKLLDSFLEDSKKLYQAEAFSVD 136 Query: 162 FRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQ 221 F D A KQIND+V KQT GKI DLLK+LDS+ V+++VN I+FK KW+ F+ + T+E+ Sbjct: 137 F-DPEEAKKQINDWVEKQTNGKIKDLLKDLDSDTVLVLVNAIYFKGKWKKPFDPENTKEE 195 Query: 222 DFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENG 281 DF+V +T V+VPMMS++ +++Y D LSC+V+ +PY+GNA+ L ILP EG +Q +E Sbjct: 196 DFHVDEKTTVKVPMMSQKGKFYYYHDDELSCKVLELPYKGNASMLIILPDEGGLQHLEQS 255 Query: 282 LSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSN 341 L+ +TL KWLK +R +ELYLPKF IEG+Y L++VL +LGI+++F+ ADLSGI+ Sbjct: 256 LTPETLSKWLKSLTRRSVELYLPKFKIEGTYDLKEVLSNLGITDLFSPGADLSGITEEK- 314 Query: 342 IQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDN---NIL 398 + VS+ VHKAV+EV+E GT AAAAT F +RPFL I +N +IL Sbjct: 315 LYVSKAVHKAVLEVNEEGTEAAAAT---FLEAIPMSIPPEFKADRPFLFLIRENKTGSIL 371 Query: 399 FLGKVNRP 406 F+GKV P Sbjct: 372 FMGKVVNP 379 >2OL2-A nrPDB Length = 395 Score = 502 bits (1294), Expect = e-143, Method: Composition-based stats. Identities = 372/376 (98%), Positives = 374/376 (99%), Gaps = 1/376 (0%) Query: 32 EDLH-VGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQ 90 +D H VGATVAPSSRRDFTFDLYRALASAAPSQ+IFFSPVSISMSLAMLSLGAGSSTKMQ Sbjct: 20 DDKHMVGATVAPSSRRDFTFDLYRALASAAPSQNIFFSPVSISMSLAMLSLGAGSSTKMQ 79 Query: 91 ILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMK 150 ILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMK Sbjct: 80 ILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMK 139 Query: 151 TLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWE 210 TLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWE Sbjct: 140 TLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWE 199 Query: 211 TSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILP 270 TSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILP Sbjct: 200 TSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILP 259 Query: 271 SEGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSH 330 SEGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSH Sbjct: 260 SEGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSH 319 Query: 331 ADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLM 390 ADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLM Sbjct: 320 ADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLM 379 Query: 391 FIVDNNILFLGKVNRP 406 FIVDNNILFLGKVNRP Sbjct: 380 FIVDNNILFLGKVNRP 395 >3NE4-A nrPDB Length = 424 Score = 462 bits (1190), Expect = e-131, Method: Composition-based stats. Identities = 179/412 (43%), Positives = 249/412 (60%), Gaps = 22/412 (5%) Query: 6 LLCLVLLS----PQGASLHR----HHPREMKKRVEDLHVGATVAPSSRRDFTFDLYRALA 57 L CLV +S PQG + + HH ++ H + +F F LYR LA Sbjct: 21 LCCLVPVSLAEDPQGDAAQKTDTSHHDQD--------HPTFNKITPNLAEFAFSLYRQLA 72 Query: 58 SAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLLQE 117 + S +IFFSPVSI+ + AMLSLG + T +ILEGL NL + E ++H GFQ+LL+ Sbjct: 73 HQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRT 132 Query: 118 LNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVA 177 LNQP QL+ GN LF + L D F+ +K LY ++ F NF D+ A KQINDYV Sbjct: 133 LNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVE 192 Query: 178 KQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMS 237 K T+GKIVDL+K LD + V +VNYIFFK KWE F K T+E+DF+V T V+VPMM Sbjct: 193 KGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMK 252 Query: 238 REDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLSEKTLRKWLKMFKKR 297 R ++ + LS V+ + Y GNATA+F LP EGK+Q +EN L+ + K+L+ +R Sbjct: 253 RLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRR 312 Query: 298 QLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDE 357 L+LPK SI G+Y L+ VL LGI+ VF++ ADLSG++ + +++S+ VHKAV+ +DE Sbjct: 313 SASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDE 372 Query: 358 SGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDN---NILFLGKVNRP 406 GT AA G +F + FN+PF+ +++ + LF+GKV P Sbjct: 373 KGTEAA---GAMFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNP 421 >3DY0-A nrPDB Length = 336 Score = 452 bits (1162), Expect = e-127, Method: Composition-based stats. Identities = 335/336 (99%), Positives = 336/336 (100%) Query: 37 GATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLG 96 GATVAPSSRRDFTFDLYRALASAAPSQ+IFFSPVSISMSLAMLSLGAGSSTKMQILEGLG Sbjct: 1 GATVAPSSRRDFTFDLYRALASAAPSQNIFFSPVSISMSLAMLSLGAGSSTKMQILEGLG 60 Query: 97 LNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLAD 156 LNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLAD Sbjct: 61 LNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLAD 120 Query: 157 TFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHK 216 TFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHK Sbjct: 121 TFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHK 180 Query: 217 GTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQ 276 GTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQ Sbjct: 181 GTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQ 240 Query: 277 QVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGI 336 QVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGI Sbjct: 241 QVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGI 300 Query: 337 SNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTF 372 SNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTF Sbjct: 301 SNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTF 336 >6HGE-B nrPDB Length = 409 Score = 447 bits (1151), Expect = e-126, Method: Composition-based stats. Identities = 186/378 (49%), Positives = 248/378 (65%), Gaps = 7/378 (1%) Query: 35 HVGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEG 94 HV +A S+ DF F LY+ L AP +++ FSP+SIS +LA LSLGA ++T +IL+G Sbjct: 30 HVDRGLA-SANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKG 88 Query: 95 LGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYL 154 L NL ++SE E+H+ FQ LL+ LNQ D QLS+GNA+F + L D F K LY Sbjct: 89 LKFNLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYG 148 Query: 155 ADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFN 214 ++ F T+F+DSA A K INDYV T+GKI DL+K+LDS ++++VNYIFFKAKWE F+ Sbjct: 149 SEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKWEMPFD 208 Query: 215 HKGTQEQDFYVTSETVVRVPMMSRED-QYHYLLDRNLSCRVVGVPYQGNATALFILPSEG 273 + T + FY++ + V VPMMS Y D LSC VV + Y GNA+ALFILP + Sbjct: 209 PQDTHQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVQLNYTGNASALFILPDQD 268 Query: 274 KMQQVENGLSEKTLRKWLKMFKKRQL-ELYLPKFSIEGSYQLEKVLPSLGISNVFTSHAD 332 KM++VE LS +TL +W + R++ ELYLPKFSI Y L +L LGI FTS AD Sbjct: 269 KMEEVEAMLSRETLNRWGDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKAD 328 Query: 333 LSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRL-VFNRPFLMF 391 LSGI+ N+ VS++VHKAV++V E GT A+AAT T SA + ++ + FNRPFLM Sbjct: 329 LSGITGARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRFNRPFLMI 388 Query: 392 IVDN---NILFLGKVNRP 406 IVD+ +I F+ KV P Sbjct: 389 IVDHFTWSIFFMSKVTNP 406 >2VDY-A nrPDB Length = 373 Score = 433 bits (1113), Expect = e-122, Method: Composition-based stats. Identities = 159/368 (43%), Positives = 232/368 (63%), Gaps = 6/368 (1%) Query: 42 PSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQK 101 S+ DF F LY+ L + +P ++IF SPVSISM+LAMLSLG T+ Q+L+GLG NL + Sbjct: 8 ASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTE 67 Query: 102 SSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTN 161 SE E+H+GFQ L Q + ++++GNALF D ++L ++F + +K Y ++ N Sbjct: 68 RSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMN 127 Query: 162 FRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQ 221 F+D A A +QIN YV +T+GKIVDL LDS A++++VNYIFFK W F+ T+E+ Sbjct: 128 FQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREE 187 Query: 222 DFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENG 281 +FYV TVV+VPMM + YL D L C++V + Y GN T FILP +GKM V Sbjct: 188 NFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAA 247 Query: 282 LSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSN 341 LS T+ +W Q++LY+PK +I G Y L VL +GI+++FT+ A+ S I+ + Sbjct: 248 LSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTTQANFSRITQDAQ 307 Query: 342 IQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDN---NIL 398 ++ S++VHKAV++++E GT AA G +F R L FN+PF++ I D+ + L Sbjct: 308 LKSSKVVHKAVLQLNEEGTEAA---GAMFLEAIPRSKPIILRFNQPFIIMIFDHFTWSSL 364 Query: 399 FLGKVNRP 406 FL +V P Sbjct: 365 FLARVMNP 372 >5HGC-A nrPDB Length = 380 Score = 432 bits (1111), Expect = e-121, Method: Composition-based stats. Identities = 161/374 (43%), Positives = 239/374 (63%), Gaps = 6/374 (1%) Query: 36 VGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGL 95 + A + DF F +R + AP+++IF+SPVSIS + AML+LGA S+T+ QILEGL Sbjct: 6 MAALKLVPNNADFAFQFFREVTQEAPNKNIFYSPVSISTAFAMLALGARSATQSQILEGL 65 Query: 96 GLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLA 155 NL + EKE+H GF L+ LN P G QL++ NA+F + L F+ K LY Sbjct: 66 AFNLTEIQEKEIHEGFHNLIHMLNHPEGGVQLNMMNAIFVTAALALLRKFLDDAKALYQL 125 Query: 156 DTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNH 215 + F T+F A KQINDY+ ++T GKI +L+K++D V+++ ++++FK WE F Sbjct: 126 EAFTTDFNKPTEAEKQINDYIERKTHGKITNLVKDMDPQTVMLLASFVYFKGSWEKPFEA 185 Query: 216 KGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKM 275 + T+E++F+V +ET V+VPMM + ++ + D LSC VV + Y G+ATA +LP++GKM Sbjct: 186 EHTEEREFFVDAETTVKVPMMYQMGRFDFYFDEELSCTVVRLHYNGSATAFLVLPAKGKM 245 Query: 276 QQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSG 335 +Q+E L ++T++KW +R + LY PKFSI GSY++ L +GI +VFT+ ADLSG Sbjct: 246 KQLEQTLDKETIQKWSDHLFQRFMNLYFPKFSISGSYEISNTLRKMGIVDVFTNQADLSG 305 Query: 336 ISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVD- 394 I+ +++VS++VHKA ++VDE GT AAAAT S + F+ PFLM I D Sbjct: 306 ITGSPDLKVSKVVHKASLDVDEKGTEAAAATAVEIMPISF---PPTIEFSHPFLMLIFDR 362 Query: 395 --NNILFLGKVNRP 406 N+ LF+GK+ P Sbjct: 363 DTNSTLFIGKIVNP 376 >1YXA-A nrPDB Length = 398 Score = 427 bits (1098), Expect = e-120, Method: Composition-based stats. Identities = 180/398 (45%), Positives = 241/398 (60%), Gaps = 12/398 (3%) Query: 14 PQGASLHRHHPREMKKRVEDLHVGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSIS 73 A++ H + + S DF F LY+ L P +I FSP+SIS Sbjct: 7 GMDAAVQEDHD-------NGTQLDSLTLASINTDFAFSLYKELVLKNPDTNIVFSPLSIS 59 Query: 74 MSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNAL 133 +LA++SLGA +T +ILEGL NL ++SE ++H+GF LLQ LNQP+D Q+S G+AL Sbjct: 60 AALALVSLGAKGNTLEEILEGLKFNLTETSEADIHQGFGHLLQRLNQPKDQVQISTGSAL 119 Query: 134 FTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDS 193 F + + F KTLY A+ F +F+ A K INDYV KQT+G I +L+ +LD Sbjct: 120 FIEKRQQILTEFQEKAKTLYQAEAFTADFQQPRQAKKLINDYVRKQTQGMIKELVSDLDK 179 Query: 194 NAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSRED-QYHYLLDRNLSC 252 ++++VNYI+FKAKW+ F+ T + +FY V VPMMS ED Y D LSC Sbjct: 180 RTLMVLVNYIYFKAKWKVPFDPLDTFKSEFYCGKRRPVIVPMMSMEDLTTPYFRDEELSC 239 Query: 253 RVVGVPYQGNATALFILPSEGKMQQVENGLSEKTLRKWLKMFKKRQL-ELYLPKFSIEGS 311 VV + Y GNA+ALFILP +G+MQQVE L +TLRKW K R + EL+LPKFSI Sbjct: 240 TVVELKYTGNASALFILPDQGRMQQVEASLQPETLRKWKNSLKPRMIDELHLPKFSISTD 299 Query: 312 YQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFT 371 Y LE VL LGI VF++ ADLS I+ +++VS++VHKAV++V E+GT AAAATG F Sbjct: 300 YSLEDVLSKLGIREVFSTQADLSAITGTKDLRVSQVVHKAVLDVAETGTEAAAATGVKFV 359 Query: 372 FRSARLNSQRLVFNRPFLMFIVDNNI---LFLGKVNRP 406 SA+L + FNRPFL+ I D F+ K+ P Sbjct: 360 PMSAKLYPLTVYFNRPFLIMIFDTETEIAPFIAKIANP 397 >1BY7-A nrPDB Length = 382 Score = 416 bits (1071), Expect = e-117, Method: Composition-based stats. Identities = 119/390 (30%), Positives = 211/390 (54%), Gaps = 22/390 (5%) Query: 31 VEDLHVGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQ 90 +EDL V T+ F +L++ LA A+P+Q++F SP SIS ++AM+ +G+ ST+ Q Sbjct: 1 MEDLCVANTL-------FALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQ 53 Query: 91 ILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMK 150 + + L N ++ ++H F+ L +N + L N LF + ++ ++ + Sbjct: 54 MAKVLQFNEVGAAADKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQ 113 Query: 151 TLYLADTFPTNFRD-SAGAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKA 207 Y ++ +F + + A K+IN +V QTKGKI +LL +D + +++VN ++FK Sbjct: 114 KYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKG 173 Query: 208 KWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALF 267 KW+T F K F V S V MM ++ + +L +++ +PY G+ + Sbjct: 174 KWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFL 233 Query: 268 ILPSE-----GKMQQVENGLSEKTLRKWL--KMFKKRQLELYLPKFSIEGSYQLEKVLPS 320 +LP E ++ +E+ ++ L KW + ++E+Y+P+F +E Y+L +L S Sbjct: 234 LLPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRS 293 Query: 321 LGISNVFTS-HADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNS 379 +G+ + F A+ SG+S +++ +SE+ H+A+V+V+E GT AAA TG + T R+ Sbjct: 294 MGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGP 353 Query: 380 QRLVFNRPFLMFIVD---NNILFLGKVNRP 406 Q V + PFL I+ N ILF G+ + P Sbjct: 354 Q-FVADHPFLFLIMHKITNCILFFGRFSSP 382 >6F02-A nrPDB Length = 389 Score = 408 bits (1048), Expect = e-114, Method: Composition-based stats. Identities = 175/374 (46%), Positives = 245/374 (65%), Gaps = 8/374 (2%) Query: 41 APSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQ 100 + DF F Y +AS P ++IFFSP+SIS + AMLSLGA S ++ QILEGLG NL Sbjct: 7 IAPANADFAFRFYYLIASETPGKNIFFSPLSISAAYAMLSLGACSHSRSQILEGLGFNLT 66 Query: 101 KSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPT 160 + SE ++HRGFQ LL LN P G + +G+ALF + F++ +Y A F T Sbjct: 67 ELSESDVHRGFQHLLHTLNLPGHGLETRVGSALFLSHNLKFLAKFLNDTMAVYEAKLFHT 126 Query: 161 NFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQE 220 NF D+ G ++ IND+V K+T+GKIVDL+ L + ++++VNYI+FKA WE F T Sbjct: 127 NFYDTVGTIQLINDHVKKETRGKIVDLVSELKKDVLMVLVNYIYFKALWEKPFISSRTTP 186 Query: 221 QDFYVTSETVVRVPMMSREDQYH-YLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVE 279 +DFYV T VRVPMM ++ ++H YL DR L C V+ + Y+G+AT FILP++GKM+++E Sbjct: 187 KDFYVDENTTVRVPMMLQDQEHHWYLHDRYLPCSVLRMDYKGDATVFFILPNQGKMREIE 246 Query: 280 NGLSEKTLRKWLKMFKKR----QLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSG 335 L+ + L +W + +KR +LEL+LPKFSI GSY L+++LP LG +++F+ ADLSG Sbjct: 247 EVLTPEMLMRWNNLLRKRNFYKKLELHLPKFSISGSYVLDQILPRLGFTDLFSKWADLSG 306 Query: 336 ISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIV-- 393 I+ ++ S+ HKA ++VDE+GT AAAAT F SA+ N L FNRPFL+ I Sbjct: 307 ITKQQKLEASKSFHKATLDVDEAGTEAAAATSFAIKFFSAQTNRHILRFNRPFLVVIFST 366 Query: 394 -DNNILFLGKVNRP 406 ++LFLGKV P Sbjct: 367 STQSVLFLGKVVDP 380 >1C5G-A nrPDB Length = 402 Score = 400 bits (1027), Expect = e-112, Method: Composition-based stats. Identities = 115/414 (27%), Positives = 209/414 (50%), Gaps = 33/414 (7%) Query: 5 LLLCLVLLSPQGASLHRHHPREMKKRVEDLHVGATVAPSSRRDFTFDLYRALASAAPSQS 64 L+L L L+ +G+++H H P + H+ + DF +++ +A A+ ++ Sbjct: 10 LVLGLALVFGEGSAVH-HPPSYVA------HLAS--------DFGVRVFQQVAQASKDRN 54 Query: 65 IFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDG 124 + FSP ++ LAML L G T+ QI +G K +K + + L +EL P + Sbjct: 55 VVFSPYGVASVLAMLQLTTGGETQQQIQAAMGF---KIDDKGMAPALRHLYKELMGPWNK 111 Query: 125 FQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKI 184 ++S +A+F + L F+ L+ + +F + A IND+V TKG I Sbjct: 112 DEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMI 171 Query: 185 VDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQY 242 +LL +D +++VN ++F +W+T F T + F+ + + V VPMM++ +++ Sbjct: 172 SNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKF 231 Query: 243 HY---LLDRNLSCRVVGVPYQGNATALFI---LPSEGKMQQVENGLSEKTLRKWLKMFKK 296 +Y ++ +PY G+ ++FI E + + N LS + + W + Sbjct: 232 NYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTR 291 Query: 297 RQLELYLPKFSIEGSYQLEKVLPSLGISNVFTS-HADLSGISNHSNIQVSEMVHKAVVEV 355 L LPKFS+E L K L +LG++++F AD + +S+ + V++ + K +EV Sbjct: 292 LPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEV 351 Query: 356 DESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDN---NILFLGKVNRP 406 +ESGT A+++T I SAR+ + ++ +RPFL + N +LF+G+V P Sbjct: 352 NESGTVASSSTAVIV---SARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP 402 >4Y40-A nrPDB Length = 414 Score = 396 bits (1019), Expect = e-111, Method: Composition-based stats. Identities = 143/374 (38%), Positives = 222/374 (59%), Gaps = 8/374 (2%) Query: 36 VGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGL 95 + A D F L + LA P ++IF SP+SIS + +ML LGA ST +I + Sbjct: 43 MAAKELARQNMDLGFKLLKKLAFYNPGRNIFLSPLSISTAFSMLCLGAQDSTLDEIKQ-- 100 Query: 96 GLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLA 155 G N +K EK+LH GF ++ EL Q +LS+GN LF D + Q F+ K Y A Sbjct: 101 GFNFRKMPEKDLHEGFHYIIHELTQKTQDLKLSIGNTLFIDQRLQPQRKFLEDAKNFYSA 160 Query: 156 DTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNH 215 +T TNF++ A KQIND+++++T GKI +L++N+D V+++ NYIFF+A+W+ F+ Sbjct: 161 ETILTNFQNLEMAQKQINDFISQKTHGKINNLIENIDPGTVMLLANYIFFRARWKHEFDP 220 Query: 216 KGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKM 275 T+E+DF++ + V+VPMM R Y D LSC ++ +PYQ N TA+FILP EGK+ Sbjct: 221 NVTKEEDFFLEKNSSVKVPMMFRSGIYQVGYDDKLSCTILEIPYQKNITAIFILPDEGKL 280 Query: 276 QQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSG 335 + +E GL T +W + +R + + +P+ + G++ L+K L +G+S +F H DL+ Sbjct: 281 KHLEKGLQVDTFSRWKTLLSRRVVCVSVPRLHMTGTFDLKKTLSYIGVSKIFEEHGDLTK 340 Query: 336 ISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDN 395 I+ H +++V E VHKA +++DE GT AA TG L + ++P+L+ I Sbjct: 341 IAPHRSLKVGEAVHKAELKMDERGTEGAAGTGAQTLPMETPLC---VKIDKPYLLLIYSE 397 Query: 396 ---NILFLGKVNRP 406 ++LFLGK+ P Sbjct: 398 KIPSVLFLGKIVNP 411 >1QMB-A nrPDB Length = 326 Score = 395 bits (1015), Expect = e-110, Method: Composition-based stats. Identities = 157/325 (48%), Positives = 212/325 (65%), Gaps = 2/325 (0%) Query: 41 APSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQ 100 + +F F LYR LA + S +IFFSPVSI+ + AMLSLG + T +ILEGL NL Sbjct: 2 ITPNLAEFAFSLYRQLAHQS-STNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLT 60 Query: 101 KSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPT 160 + E +H GFQ+LL+ LNQP QL+ GN LF + L D F+ +K LY ++ F Sbjct: 61 EIPEAAIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTV 120 Query: 161 NFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQE 220 NF D+ A KQINDYV K T+GKIVDL+K LD + V +VNYIFFK KWE F K T+E Sbjct: 121 NFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEE 180 Query: 221 QDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVEN 280 +DF+V T V+VPMM R ++ + LS V+ + Y GNATA+F LP EGK+Q +EN Sbjct: 181 EDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLEN 240 Query: 281 GLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHS 340 L+ + K+L+ +R L+LPK SI G+Y L+ VL LGI+ VF++ ADLSG++ + Sbjct: 241 ELTHDIITKFLEN-DRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEA 299 Query: 341 NIQVSEMVHKAVVEVDESGTRAAAA 365 +++S+ VHKAV+ +DE GT AA A Sbjct: 300 PLKLSKAVHKAVLTIDEKGTEAAGA 324 >2XN5-A nrPDB Length = 350 Score = 386 bits (991), Expect = e-107, Method: Composition-based stats. Identities = 138/342 (40%), Positives = 211/342 (61%), Gaps = 4/342 (1%) Query: 42 PSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQK 101 S DF F+LYR P ++IFFSPVSIS +L MLS GA ST+ +I+E LG NL Sbjct: 12 SSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTD 71 Query: 102 SSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTN 161 + E+ GFQ L+ LN P+ +L +GNALF + F++ +KTLY + F T+ Sbjct: 72 TPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTD 131 Query: 162 FRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQE- 220 F + + A ++IN +V QTKGK+V L+++L N ++++VNYI FKA+W F+ T++ Sbjct: 132 FSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDS 191 Query: 221 QDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVEN 280 F + T V+VPMM + +QY++L+D L+C V+ + Y NA ALF+LP EG+M+ VE Sbjct: 192 SSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEA 251 Query: 281 GLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHS 340 +S KTL+KW ++ +K ++L++PKFSI +Y L L +GI + ++ +AD SG++ + Sbjct: 252 AMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDN 311 Query: 341 NIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRL 382 +++S HKAV+ + E GT AA G +F R Sbjct: 312 GLKLSNAAHKAVLHIGEKGTEAA---GAMFLEAIPRSIPNTF 350 >4GA7-A nrPDB Length = 389 Score = 385 bits (990), Expect = e-107, Method: Composition-based stats. Identities = 122/385 (31%), Positives = 200/385 (51%), Gaps = 20/385 (5%) Query: 37 GATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLG 96 G S+ F DL+ AL+ P+ +IF SP SIS ++AM+ LG +T Q+ + Sbjct: 10 GMEQLSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFH 69 Query: 97 LNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLAD 156 N + +E+H FQ L ++N+ + L L N L+ + + F+ + + Y AD Sbjct: 70 FN----TVEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGAD 125 Query: 157 TFPTNFRD-SAGAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSF 213 +F+ S A K IN +V QT+GKI +LL + +D+ +++VN I+FK W+ F Sbjct: 126 LASVDFQHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKF 185 Query: 214 NHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFI-LPSE 272 + T F + + V MM ++ ++ Y +L CRV+ +PYQG ++ I LP + Sbjct: 186 MKEATTNAPFRLNKKDRKTVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDD 245 Query: 273 -----GKMQQVENGLSEKTLRKWLK--MFKKRQLELYLPKFSIEGSYQLEKVLPSLGISN 325 ++++E L+ + L +W K ++ + LP+F +E SY L L LG+ + Sbjct: 246 IEDESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQD 305 Query: 326 VF-TSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVF 384 +F +S ADLSG+S +I +S++VHK+ VEV+E AAA + Sbjct: 306 LFNSSKADLSGMSGARDIFISKIVHKSFVEVNEE-GTEAAAATAGIATFCMDDPEENFTA 364 Query: 385 NRPFLMFIVDN---NILFLGKVNRP 406 + PFL FI N +ILFLG+ + P Sbjct: 365 DHPFLFFIRHNSSGSILFLGRFSSP 389 >4EB1-I nrPDB Length = 440 Score = 385 bits (989), Expect = e-107, Method: Composition-based stats. Identities = 112/387 (28%), Positives = 204/387 (52%), Gaps = 23/387 (5%) Query: 42 PSSRRDFTFDLYRALA-SAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLN-L 99 + F Y+ LA S + +IF SP+SIS + AM LGA + T Q++E + + Sbjct: 52 SKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTI 111 Query: 100 QKSSEKELHRGFQQLLQELN-QPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTF 158 + + ++H F +L L + +L N LF D + +T+ + +Y A Sbjct: 112 SEKTSDQIHFFFAKLNCRLYRKANKASKLVSANRLFGDKSLTFNETYQDISELVYGAKLQ 171 Query: 159 PTNFRDS-AGAMKQINDYVAKQTKGKIVDLLK----------NLDSNAVVIMVNYIFFKA 207 P +F+++ + IN +V+ +T+G+I D++ N ++ V+++VN I+FK Sbjct: 172 PLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINVLVLVNTRTSTVLVLVNTIYFKG 231 Query: 208 KWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQG-NATAL 266 W++ F+ + T+++ FY MM +E ++ Y +V+ +P++G + T + Sbjct: 232 LWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAE-GTQVLELPFKGDDITMV 290 Query: 267 FILPS-EGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISN 325 ILP E + +VE L+ + L++WL ++ L +++P+F IE + L++ L +G+ + Sbjct: 291 LILPKPEKSLAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVD 350 Query: 326 VFTSH-ADLSGI--SNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRL 382 +F+ + L GI ++ VS+ HKA +EV+E G+ AAA+T + RS N Sbjct: 351 LFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTF 410 Query: 383 VFNRPFLMFIVD---NNILFLGKVNRP 406 NRPFL+FI + N I+F+G+V P Sbjct: 411 KANRPFLVFIREVPLNTIIFMGRVANP 437 >1ATT-A nrPDB Length = 429 Score = 384 bits (987), Expect = e-107, Method: Composition-based stats. Identities = 116/406 (28%), Positives = 213/406 (52%), Gaps = 22/406 (5%) Query: 15 QGASLHRHHPREMKKRVEDLHVGATVAPSSRRDFTFDLYRALA-SAAPSQSIFFSPVSIS 73 +G + P +RV +L + F Y+ LA S + +IF SP+SIS Sbjct: 29 EGQGSEQKIPGATNRRVWEL-------SKANSHFATAFYQHLADSKNNNDNIFLSPLSIS 81 Query: 74 MSLAMLSLGAGSSTKMQILEGLGLN-LQKSSEKELHRGFQQLLQELN-QPRDGFQLSLGN 131 + AM LGA ++T Q++E + + + + ++H F +L L + +L N Sbjct: 82 TAFAMTKLGACNNTLTQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSELVSAN 141 Query: 132 ALFTDLVVDLQDTFVSAMKTLYLADTFPTNFR-DSAGAMKQINDYVAKQTKGKIVDLLKN 190 LF D + +T+ + +Y A P +F+ ++ + IN +++ +T+G+I D++ Sbjct: 142 RLFGDKSITFNETYQDISEVVYGAKLQPLDFKGNAEQSRLTINQWISNKTEGRITDVIPP 201 Query: 191 --LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDR 248 ++ V+++VN I+FK W++ F+ + T+++ FY V MM +E ++ Y Sbjct: 202 QAINEFTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSVLMMYQESKFRYRRVA 261 Query: 249 NLSCRVVGVPYQG-NATALFILPS-EGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKF 306 S +V+ +P++G + T + ILP E + +VE L+ L++WL + L +++P+F Sbjct: 262 E-STQVLELPFKGDDITMVLILPKLEKTLAKVEQELTPDMLQEWLDELTETLLVVHMPRF 320 Query: 307 SIEGSYQLEKVLPSLGISNVFTSH-ADLSGI--SNHSNIQVSEMVHKAVVEVDESGTRAA 363 IE S+ +++ L +G+ ++F+ + L GI S++ VS+ HKA +EV+E G+ AA Sbjct: 321 RIEDSFSVKEQLQDMGLEDLFSPEKSRLPGIVAEGRSDLYVSDAFHKAFLEVNEEGSEAA 380 Query: 364 AATGTIFTFRSARLNSQRLVFNRPFLMFIVD---NNILFLGKVNRP 406 A+T RS + NRPFL+ I + N I+F+G+V P Sbjct: 381 ASTVISIAGRSLNSDRVTFKANRPFLVLIREVALNTIIFMGRVANP 426 >2V95-A nrPDB Length = 371 Score = 379 bits (973), Expect = e-105, Method: Composition-based stats. Identities = 136/368 (36%), Positives = 215/368 (58%), Gaps = 10/368 (2%) Query: 42 PSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQK 101 + DF F+LY+ L + P ++ SPVSISM+LAM+SLG+ + Q L+ LG NL + Sbjct: 10 APTNVDFAFNLYQRLVALNPDKNTLISPVSISMALAMVSLGSA---QTQSLQSLGFNLTE 66 Query: 102 SSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTN 161 +SE E+H+ FQ L L Q G ++++GNA+F + L+D+F++ +K Y ++ + Sbjct: 67 TSEAEIHQSFQYLNYLLKQSDTGLEMNMGNAMFLLQKLKLKDSFLADVKQYYESEALAID 126 Query: 162 FRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQ 221 F D A +QIN +V +T+GKI + +LDS A I+VNYIF + WE F+ + T+E+ Sbjct: 127 FEDWTKASQQINQHVKDKTQGKIEHVFSDLDSPASFILVNYIFLRGIWELPFSPENTREE 186 Query: 222 DFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENG 281 DFYV + V+VPMM + Y D C+++ + Y GN TA FILP +G+M V Sbjct: 187 DFYVNETSTVKVPMMVQSGSIGYFRDSVFPCQLIQMDYVGNGTAFFILPDQGQMDTVIAA 246 Query: 282 LSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSN 341 LS T+ +W K+ RQ+ LY+PKFS+ +Y L+ VL L I ++ T+ +D SG + Sbjct: 247 LSRDTIDRWGKLMTPRQVNLYIPKFSMSDTYDLKDVLEDLNIKDLLTNQSDFSGNTKDVP 306 Query: 342 IQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDN---NIL 398 + ++ MVHKA++++DE + G RS + FN+PF++ + D + L Sbjct: 307 LTLT-MVHKAMLQLDEGNVLPNSTNGAPLHLRS---EPLDIKFNKPFILLLFDKFTWSSL 362 Query: 399 FLGKVNRP 406 + +V P Sbjct: 363 MMSQVVNP 370 >4ZK0-A nrPDB Length = 390 Score = 376 bits (967), Expect = e-105, Method: Composition-based stats. Identities = 118/387 (30%), Positives = 207/387 (53%), Gaps = 23/387 (5%) Query: 42 PSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLN--- 98 + F FDL++ + + +IF+SP+SI+ +L M+ LGA +T QI + L + Sbjct: 5 SEANTKFMFDLFQQFRKSKEN-NIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQVT 63 Query: 99 ---------LQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAM 149 +H FQ+LL E N+ D ++L + N LF + ++ A+ Sbjct: 64 ENTTGKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLDAI 123 Query: 150 KTLYLADTFPTNFRD-SAGAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFK 206 K Y +F + + K+IN +V QT KI +L+ + SN +++VN I+FK Sbjct: 124 KKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFK 183 Query: 207 AKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQG-NATA 265 +WE FN + T+E+ F+ T + MM + +H+ ++ +V+ +PY+G + + Sbjct: 184 GQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTSFHFASLEDVQAKVLEIPYKGKDLSM 243 Query: 266 LFILPSE-GKMQQVENGLSEKTLRKW--LKMFKKRQLELYLPKFSIEGSYQLEKVLPSLG 322 + +LP+E +Q++E L+ + L +W L+ ++ +++L+LP+F +E SY L+ L ++G Sbjct: 244 IVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLRTMG 303 Query: 323 ISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRL 382 + ++F ADLSG++ + +S ++HKA VEV E G AAAAT + S ++ Sbjct: 304 MVDIFNGDADLSGMTGSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFGSSPTSTNEEF 363 Query: 383 VFNRPFLMFIV---DNNILFLGKVNRP 406 N PFL FI N+ILF G+ + P Sbjct: 364 HCNHPFLFFIRQNKTNSILFYGRFSSP 390 >6F4U-A nrPDB Length = 341 Score = 376 bits (966), Expect = e-104, Method: Composition-based stats. Identities = 149/325 (45%), Positives = 215/325 (66%), Gaps = 5/325 (1%) Query: 37 GATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLG 96 G+ + DF F Y +AS P ++IFFSP+SIS + AMLSLGA S ++ QILEGLG Sbjct: 1 GSLKIAPANADFAFRFYYLIASETPGKNIFFSPLSISAAYAMLSLGACSHSRSQILEGLG 60 Query: 97 LNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLAD 156 NL + SE ++HRGFQ LL LN P G + +G+ALF + F++ +Y A Sbjct: 61 FNLTELSESDVHRGFQHLLHTLNLPGHGLETRVGSALFLSHNLKFLAKFLNDTMAVYEAK 120 Query: 157 TFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHK 216 F TNF D+ G ++ IND+V K+T+GKIVDL+ L + ++++VNYI+FKA WE F Sbjct: 121 LFHTNFYDTVGTIQLINDHVKKETRGKIVDLVSELKKDVLMVLVNYIYFKALWEKPFISS 180 Query: 217 GTQEQDFYVTSETVVRVPMMSREDQYH-YLLDRNLSCRVVGVPYQGNATALFILPSEGKM 275 T +DFYV T VRVPMM ++ ++H YL DR L C V+ + Y+G+AT FILP++GKM Sbjct: 181 RTTPKDFYVDENTTVRVPMMLQDQEHHWYLHDRYLPCSVLRMDYKGDATVFFILPNQGKM 240 Query: 276 QQVENGLSEKTLRKWLKMFKKR----QLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHA 331 +++E L+ + L +W + +KR +LEL+LPKFSI GSY L+++LP LG +++F+ A Sbjct: 241 REIEEVLTPEMLMRWNNLLRKRNFYKKLELHLPKFSISGSYVLDQILPRLGFTDLFSKWA 300 Query: 332 DLSGISNHSNIQVSEMVHKAVVEVD 356 DLSGI+ ++ S+ HKA ++VD Sbjct: 301 DLSGITKQQKLEASKSFHKATLDVD 325 >2H4Q-A nrPDB Length = 382 Score = 374 bits (961), Expect = e-104, Method: Composition-based stats. Identities = 110/349 (31%), Positives = 189/349 (54%), Gaps = 15/349 (4%) Query: 33 DLHVGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQIL 92 +L + +S +FT DL+ L ++IFFSP SIS +LA+ L A ST ++ Sbjct: 37 ELEISMEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMA 96 Query: 93 EGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTL 152 E L + +H GF++LL N+PR+ + L N ++ + L T++ K Sbjct: 97 EVLHFEQAE----NIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTYLQLSKKY 152 Query: 153 YLADTFPTNFRD-SAGAMKQINDYVAKQTKGKIVDLL--KNLDSNAVVIMVNYIFFKAKW 209 Y A+ NF+ + K+IN +V KQT+ KI +LL ++ + +I+VN I+FKA+W Sbjct: 153 YKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILVNAIYFKAEW 212 Query: 210 ETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFIL 269 E F + T Q F ++ V MM D + L+ ++ +++ +PY ++FIL Sbjct: 213 EVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPYVKRELSMFIL 272 Query: 270 -PSE-----GKMQQVENGLSEKTLRKW--LKMFKKRQLELYLPKFSIEGSYQLEKVLPSL 321 P + ++Q+E L+ + L +W KM + ++L+LPKFS+E L L ++ Sbjct: 273 LPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDRIDLRDTLRNM 332 Query: 322 GISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIF 370 G++ FT++AD G+++ ++ +S+++H++ V VDE GT A AAT I Sbjct: 333 GMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAVAATAVII 381 >4AJT-A nrPDB Length = 427 Score = 374 bits (960), Expect = e-104, Method: Composition-based stats. Identities = 113/375 (30%), Positives = 193/375 (51%), Gaps = 9/375 (2%) Query: 37 GATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLG 96 + + F F+L R + S ++ FSP +S+++ L LG TK+QI GL Sbjct: 54 ASQQLSNETSSFGFNLLRKI-SMRHDGNVIFSPFGLSVAMVNLMLGTKGETKVQIENGLN 112 Query: 97 LNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLAD 156 L + + + ++E LS G+ F D+++T+ + K + + Sbjct: 113 LQALSQAGPLILPALFKKVKETFSSNRDLGLSQGSFAFIHKDFDIKETYFNLSKKYFDIE 172 Query: 157 TFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHK 216 NF++S+ A IN + K+T+GKI L ++ +I+V+Y+ FK KW T F+ Sbjct: 173 YVSINFQNSSQARGLINHCIVKETEGKIPKLFDEINPETKLILVDYVLFKGKWLTPFDPS 232 Query: 217 GTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSE-GKM 275 T+ F++ ++VPMM RE + D+ C ++ +PYQGNAT L +L + G Sbjct: 233 FTEADTFHLDKYRAIKVPMMYREGNFTSTFDKKFRCHILKLPYQGNATMLVVLMEKTGDY 292 Query: 276 QQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSG 335 +E+ L+ + WL+ K R++E++ PKF + Y++ ++L +GI +F++ ADLS Sbjct: 293 LALEDYLTVDLVETWLQNMKTRKMEVFFPKFKLNQRYEMHELLKQMGIRRLFSTSADLSE 352 Query: 336 ISN-HSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVD 394 +S N+QVS ++ ++V+EVDE GT A + T + S + NRPF I + Sbjct: 353 LSAMARNLQVSRVLQQSVLEVDERGTEAVSGTLSEIIAYSM---PPAIKVNRPFHFIIYE 409 Query: 395 N---NILFLGKVNRP 406 +LFLG+V P Sbjct: 410 EMSRMLLFLGRVVNP 424 >2H4P-A nrPDB Length = 394 Score = 371 bits (952), Expect = e-103, Method: Composition-based stats. Identities = 111/379 (29%), Positives = 194/379 (51%), Gaps = 35/379 (9%) Query: 27 MKKRVEDLHVGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSS 86 + + +L + +S +FT DL+ L ++IFFSP SIS +LA+ L A S Sbjct: 15 VPRGSHELEISMEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGS 74 Query: 87 TKMQILEGLGL------------------------NLQKSSEKELHRGFQQLLQELNQPR 122 T ++ E L + + + +H GF++LL N+PR Sbjct: 75 TAREMAEVLHFTEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPR 134 Query: 123 DGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRD-SAGAMKQINDYVAKQTK 181 + + L N ++ + L T++ K Y A+ NF+ + K+IN +V KQT+ Sbjct: 135 NNYSLRSANRIYVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTE 194 Query: 182 GKIVDLL--KNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSRE 239 KI +LL ++ + +I+VN I+FKA+WE F + T Q F ++ V MM Sbjct: 195 SKIKNLLSSDDVKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMR 254 Query: 240 DQYHYLLDRNLSCRVVGVPYQGNATALFIL-PSE-----GKMQQVENGLSEKTLRKW--L 291 D + L+ ++ +++ +PY ++FIL P + ++Q+E L+ + L +W Sbjct: 255 DTFPVLIMEKMNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADS 314 Query: 292 KMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKA 351 KM + ++L+LPKFS+E L L ++G++ FT++AD G+++ ++ +S+++H++ Sbjct: 315 KMMTETLVDLHLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQS 374 Query: 352 VVEVDESGTRAAAATGTIF 370 V VDE GT AAAAT I Sbjct: 375 FVAVDEKGTEAAAATAVII 393 >3LW2-A nrPDB Length = 379 Score = 370 bits (951), Expect = e-103, Method: Composition-based stats. Identities = 109/374 (29%), Positives = 193/374 (51%), Gaps = 18/374 (4%) Query: 45 RRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSE 104 DF +++ + A+ +++ FSP +S LAML + T+ QI + +G K +E Sbjct: 12 ATDFGVKVFQQVVQASKDRNVVFSPYGVSSVLAMLQMTTAGKTRRQIQDAMGF---KVNE 68 Query: 105 KELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRD 164 K +QL +EL P + ++S +A+F ++L F+ L+ +F + Sbjct: 69 KGTAHALRQLSKELMGPWNKNEISTADAIFVQRDLELVQGFMPHFFKLFQTMVKQVDFSE 128 Query: 165 SAGAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQD 222 A IND+V + TKG I DLL +D +++VN ++F +W+T F T ++ Sbjct: 129 VERARFIINDWVERHTKGMINDLLAKGAVDELTRLVLVNALYFSGQWKTPFLEASTHQRL 188 Query: 223 FYVTSETVVRVPMMSREDQYHY---LLDRNLSCRVVGVPYQGNATALFI---LPSEGKMQ 276 F+ + + V VPMM++ ++++Y L VV +PYQG+ ++FI + + Sbjct: 189 FHKSDGSTVSVPMMAQSNKFNYTEFTTPDGLEYDVVELPYQGDTLSMFIAAPFEKDVHLS 248 Query: 277 QVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSH-ADLSG 335 + N L + +R+W + L LPKFS+E L L LG+ ++F++ AD + Sbjct: 249 ALTNILDAELIRQWKGNMTRLPRLLILPKFSLETEVDLRGPLEKLGMPDMFSATLADFTS 308 Query: 336 ISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDN 395 +S+ + V++ + K +EV+ESGT A+++T + SAR+ +V +R FL + N Sbjct: 309 LSDQEQLSVAQALQKVRIEVNESGTVASSSTAFVI---SARMAPTEMVIDRSFLFVVRHN 365 Query: 396 ---NILFLGKVNRP 406 ILF+G+V P Sbjct: 366 PTETILFMGQVMEP 379 >3NDA-A nrPDB Length = 377 Score = 369 bits (947), Expect = e-102, Method: Composition-based stats. Identities = 115/371 (30%), Positives = 197/371 (53%), Gaps = 9/371 (2%) Query: 42 PSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQK 101 + F L RAL S P +++FFSP S+S ++ M GA T+ ++ +GLG + Sbjct: 8 TKANNRFGLRLLRALPS-GPEKNVFFSPYSVSTAMGMAFAGARGQTQQELSQGLGFSDVD 66 Query: 102 SSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTN 161 ++ + + + L L + NA + L +++ SA+++ + A+ + Sbjct: 67 LTDAGVLDAYTHHTERLKSTPSNSTLDVANAAAIQRTLALLNSYESALQSSFGAELHKVD 126 Query: 162 F-RDSAGAMKQINDYVAKQTKGKIVDLLKN-LDSNAVVIMVNYIFFKAKWETSFNHKGTQ 219 F + A+ +N++V ++T KI L LD + +++++N I+FK +W T+F + T+ Sbjct: 127 FAGEPQAAVDFVNNWVKRKTHDKIEKLFNEPLDPDTLLVLLNAIYFKGEWNTAFVKEHTE 186 Query: 220 EQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQG-NATALFILPSE-GKMQQ 277 ++ F+ T V V M E + Y +L VV +PY+G + T +LP E ++ Sbjct: 187 KRQFFNGGVTPVEVDTMRLEARIKYRFFDDLQVEVVELPYRGLDYTMAILLPKENTGVEG 246 Query: 278 VENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGIS 337 ++ L+ + +L ++R++ + LPKF +E Y L+ L SLGI +F S ADLSGI Sbjct: 247 LKQNLTIDRFQNYLSDLRERKITVLLPKFKLETKYSLKAPLQSLGIKQIFESGADLSGI- 305 Query: 338 NHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFI---VD 394 N +++VS + HKAVVEV+E GT AAA TG + S + PFL FI Sbjct: 306 NDGSLRVSAVEHKAVVEVNEEGTVAAATTGVVIVPYSLGPEPVVFRVDHPFLFFIRNTRT 365 Query: 395 NNILFLGKVNR 405 ++I F+G+VN+ Sbjct: 366 DDIFFVGQVNK 376 >1UHG-A nrPDB Length = 385 Score = 366 bits (939), Expect = e-101, Method: Composition-based stats. Identities = 109/384 (28%), Positives = 202/384 (52%), Gaps = 23/384 (5%) Query: 43 SSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNL--- 99 ++ +F FD+++ L +++IF+ P++I +LAM+ LGA ST+ QI + + + Sbjct: 5 AASMEFCFDVFKELKVHHANENIFYCPIAIMSALAMVYLGAKDSTRTQINKVVRFDKLPG 64 Query: 100 -------QKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTL 152 Q + +H + +L ++ +P D + SL + L+ + + ++ +K L Sbjct: 65 FGDSIEAQCGTSVNVHSSLRDILNQITKPNDVYSFSLASRLYAEERYPILPEYLQCVKEL 124 Query: 153 YLADTFPTNFRDSA-GAMKQINDYVAKQTKGKIVDLL--KNLDSNAVVIMVNYIFFKAKW 209 Y P NF+ +A A + IN +V QT G I ++L ++DS +++VN I FK W Sbjct: 125 YRGGLEPINFQTAADQARELINSWVESQTNGIIRNVLQPSSVDSQTAMVLVNAIVFKGLW 184 Query: 210 ETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPY-QGNATALFI 268 E +F + TQ F VT + V MM + + + +++ +P+ G + L + Sbjct: 185 EKAFKDEDTQAMPFRVTEQESKPVQMMYQIGLFRVASMASEKMKILELPFASGTMSMLVL 244 Query: 269 LPSE-GKMQQVENGLSEKTLRKWLKM--FKKRQLELYLPKFSIEGSYQLEKVLPSLGISN 325 LP E ++Q+E+ ++ + L +W ++R++++YLP+ +E Y L VL ++GI++ Sbjct: 245 LPDEVSGLEQLESIINFEKLTEWTSSNVMEERKIKVYLPRMKMEEKYNLTSVLMAMGITD 304 Query: 326 VFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFN 385 VF+S A+LSGIS+ ++++S+ VH A E++E+G G+ A S+ + Sbjct: 305 VFSSSANLSGISSAESLKISQAVHAAHAEINEAGRE---VVGSAEAGVDAASVSEEFRAD 361 Query: 386 RPFLMFIVD---NNILFLGKVNRP 406 PFL I N +LF G+ P Sbjct: 362 HPFLFCIKHIATNAVLFFGRCVSP 385 >4KDS-A nrPDB Length = 386 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 97/373 (26%), Positives = 189/373 (50%), Gaps = 21/373 (5%) Query: 46 RDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEK 105 DF ++ +A + ++ FSP ++ LAM LGAG +T + LG +LQ+ Sbjct: 20 TDFGMRVFSQVAQNSKGSNLAFSPYGVATILAMAQLGAGGNTLKTLNAKLGFSLQERGMA 79 Query: 106 ELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDS 165 Q+LLQ +G +L + + + + L+ F + + A +F Sbjct: 80 RQ----QRLLQRDISSEEGVEL--ASGVMVERKMALEKGFRRGLGKAFQASPHQLDFSRP 133 Query: 166 AGAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDF 223 A+ IN +V+ T G I L + L ++++N + F+ W+ F+ K T+E+ F Sbjct: 134 DQALDIINAWVSDHTAGTIPSFLSSGALTDETRMVLLNALHFQGLWKVPFDPKMTEERLF 193 Query: 224 YVTSETVVRVPMMSREDQYHYL---LDRNLSCRVVGVPYQGNATALFILP---SEGKMQQ 277 + + + V VPMM ++ Y + V+ VPY+G + ++ ++ E + Sbjct: 194 HCANGSSVPVPMMRLTHRFKYGEFVTPDGVDYDVIEVPYEGESLSMLLVSPFEPETPVSS 253 Query: 278 VENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFT-SHADLSGI 336 + + L+ + L++W + + + +L LP+F+++ +L+ +L +G+ ++F + AD + I Sbjct: 254 LSSELTTQRLQQWRQEMRSVKRQLVLPRFTLDSEVELKSILIQMGLGDMFNLAKADFTRI 313 Query: 337 SNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNN 396 + + VS+++ K +EV+E GT+A+AAT I +R+ + + NRPFL I + Sbjct: 314 TTEQPLCVSKVLQKVKIEVNEEGTKASAATAAILF---SRMAVEEITMNRPFLFLIHHKS 370 Query: 397 ---ILFLGKVNRP 406 +LF+G+VN+P Sbjct: 371 TGAVLFMGQVNQP 383 >1HLE-A nrPDB Length = 345 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 101/331 (30%), Positives = 185/331 (55%), Gaps = 16/331 (4%) Query: 38 ATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGL 97 ++ F DL+RAL + P+ +IF SP+SIS +LAM+ LG +T Q+ + L Sbjct: 2 MEQLSTANTHFAVDLFRALNESDPTGNIFISPLSISSALAMIFLGTRGNTAAQVSKALYF 61 Query: 98 NLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADT 157 + + +++H FQ L ++N+P + L L N L+ + + F+++ + +Y A+ Sbjct: 62 D----TVEDIHSRFQSLNADINKPGAPYILKLANRLYGEKTYNFLADFLASTQKMYGAEL 117 Query: 158 FPTNFRD-SAGAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFN 214 +F+ A K+IN++V QT+GKI +LL +D+ +++VN I+FK W+ F Sbjct: 118 ASVDFQQAPEDARKEINEWVKGQTEGKIPELLVKGMVDNMTKLVLVNAIYFKGNWQQKFM 177 Query: 215 HKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFI-LPSE- 272 + T++ F + + V MM ++ ++ Y +L CRV+ +PYQG ++ I LP + Sbjct: 178 KEATRDAPFRLNKKDTKTVKMMYQKKKFPYNYIEDLKCRVLELPYQGKELSMIILLPDDI 237 Query: 273 ----GKMQQVENGLSEKTLRKWLK--MFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNV 326 ++++E L+ LR+W K ++ ++LP+F +E SY L L LG+ ++ Sbjct: 238 EDESTGLEKIEKQLTLDKLREWTKPENLYLAEVNVHLPRFKLEESYDLTSHLARLGVQDL 297 Query: 327 FT-SHADLSGISNHSNIQVSEMVHKAVVEVD 356 F ADLSG+S ++ VS+++HK+ V+++ Sbjct: 298 FNRGKADLSGMSGARDLFVSKIIHKSFVDLN 328 >1JMJ-A nrPDB Length = 480 Score = 363 bits (931), Expect = e-100, Method: Composition-based stats. Identities = 107/372 (28%), Positives = 181/372 (48%), Gaps = 15/372 (4%) Query: 45 RRDFTFDLYRALASAAPS-QSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLN----- 98 F F+LYR L + +IF +PV IS ++ M+SLG T Q+ L Sbjct: 111 NAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNA 170 Query: 99 LQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTF 158 K +H F++L L + G+ L N L+ + F + ++ Y A+ Sbjct: 171 SSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQ 230 Query: 159 PTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGT 218 +F D A K N+++ K TKG I D L+N+D ++++N I+FK W F + T Sbjct: 231 IADFSDPAFISKT-NNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMT 289 Query: 219 QEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSE-GKMQQ 277 +F + VV+V MM + + D+ L C ++ + Y G + L ++P + M+ Sbjct: 290 HNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKT 349 Query: 278 VENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGIS 337 +E L+ + + +W K R E+ LPKF +E +Y L + L +GI +F + +++GIS Sbjct: 350 LEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGIS 409 Query: 338 NHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNN- 396 + I + H+ + V+E GT+A T F S ++ R +RPFL I ++ Sbjct: 410 DQR-IAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQV---RFTVDRPFLFLIYEHRT 465 Query: 397 --ILFLGKVNRP 406 +LF+G+V P Sbjct: 466 SCLLFMGRVANP 477 >4P0F-A nrPDB Length = 393 Score = 359 bits (922), Expect = 1e-99, Method: Composition-based stats. Identities = 107/368 (29%), Positives = 184/368 (50%), Gaps = 15/368 (4%) Query: 48 FTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKEL 107 F+ ++Y L+ P ++I FSP SI AM LGA + T Q+ +GLG L S +++ Sbjct: 17 FSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQLDQGLG--LASSDPEQI 74 Query: 108 HRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAG 167 F Q+L +D L + N +F L+ F + +L+ +F + Sbjct: 75 AHSFHQVLAAY---QDSQILRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNVQ 131 Query: 168 AMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYV 225 A IN++V ++T I DL+ L+S + +++VN I FK W+ F T+ F++ Sbjct: 132 AAATINNWVEQRTNHLIKDLVPADVLNSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHL 191 Query: 226 TSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQG-NATALFILPS-EGKMQQVENGLS 283 E V+VPMMS ++++ Y L + +PY+ + + L +LP+ + + +E L Sbjct: 192 DGERTVQVPMMSLKERFRYADLPALDAMALELPYKDSDLSMLIVLPNTKTGLPALEEKLR 251 Query: 284 EKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGI-SNHSNI 342 TL + + + ++ L LP+F E +L +V LG+S +F+ A+ + + + Sbjct: 252 LTTLSQITQSLYETKVALKLPRFKAEFQVELSEVFQKLGMSRMFSDQAEFGKMLQSPEPL 311 Query: 343 QVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQ---RLVFNRPFLMFIVDNN--I 397 +VS ++HKA +EV+E GT AAAATG + A ++ + + PF +V Sbjct: 312 KVSAIIHKAFIEVNEEGTEAAAATGMAVRRKRAIMSPEEPIEFFADHPFTYVLVHQKDLP 371 Query: 398 LFLGKVNR 405 LF G V R Sbjct: 372 LFWGSVVR 379 >5NCS-A nrPDB Length = 375 Score = 358 bits (918), Expect = 4e-99, Method: Composition-based stats. Identities = 100/365 (27%), Positives = 176/365 (48%), Gaps = 13/365 (3%) Query: 46 RDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEK 105 F FDL + ++F SP+S+SM+L M GA T ++ L + + Sbjct: 12 NAFAFDLLQTTRKHVTEANVFISPLSVSMALNMTLNGAAGVTADEMKTALRE--TGYTME 69 Query: 106 ELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDS 165 +++ L + L + + + N+++ +++ F+ A +T Y A+ +F Sbjct: 70 DINEYSHSLREALLKVDPSTTIGMANSIWYKQGELVKEPFILANRTHYDAEVKAVDFSSP 129 Query: 166 AGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYV 225 A + IN + A++T KI +L + NA + ++N ++FK W T F T+ F Sbjct: 130 A-TLPAINGWCAQKTNDKITKILDYIPGNAFMYLINAVYFKGIWVTQFKKSDTKRAPFRK 188 Query: 226 TSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFI-LPSEGK-MQQVENGLS 283 T V MM+++ + Y D C+ + + Y A ++ + LP+EG+ + V L Sbjct: 189 ADGTTQEVNMMAQKSTFGYTTDE--CCQYLEMDYGNKAFSMIVMLPNEGQTTRDVIEQLD 246 Query: 284 EKTLRKWLKMFKKRQLELYLPKFSIEGSYQL-EKVLPSLGISNVFTSHADLSGISNHSNI 342 K +K + Q+ L +P+F E Y L +K+LP +G++ FT AD GI++ + I Sbjct: 247 NKHWSMIIKGIRPTQVSLRMPRFKTECKYGLEKKILPEMGMNVPFTETADFPGITDAA-I 305 Query: 343 QVSEMVHKAVVEVDESGTRAAAATGTIFT-FRSARLNSQRLVFNRPFLMFIVDNN---IL 398 +S ++HK V+VDE GT AAA T S N+PF+ I + + IL Sbjct: 306 FISRVIHKTFVQVDEEGTEAAAVTAVEMVKTSSPSTTPINFHINKPFVFAIREKSTGVIL 365 Query: 399 FLGKV 403 F+G++ Sbjct: 366 FIGEI 370 >4DY0-A nrPDB Length = 379 Score = 354 bits (910), Expect = 3e-98, Method: Composition-based stats. Identities = 97/372 (26%), Positives = 188/372 (50%), Gaps = 22/372 (5%) Query: 49 TFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELH 108 ++ + + P +I SP I+ L ML LGA TK Q+ + + Sbjct: 16 GIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRY-----GVNGVG 70 Query: 109 RGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGA 168 + +++ + + ++ +++ NA+F +++ FV+ K ++ + NF D A A Sbjct: 71 KILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASA 130 Query: 169 MKQINDYVAKQTKGKIVDLLKNLDSN---AVVIMVNYIFFKAKWETSFNHKGTQEQDFYV 225 IN +V +T+ I +LL + +++VN ++FK W++ F + T+++ F Sbjct: 131 CDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVA 190 Query: 226 TSETVVRVPMMSREDQYHYLL---DRNLSCRVVGVPYQGNATALFI-LPSEG--KMQQVE 279 +VPM+++ + +L + +PY G + ++ I LP+E + + Sbjct: 191 ADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAII 250 Query: 280 NGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVF-TSHADLSGI-S 337 +S KT+ W+ + +++++ LPKF+ L++ L LGI+++F +S A+ + I + Sbjct: 251 PHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITT 310 Query: 338 NHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDN-- 395 N+ VS ++ KA +EV E GT+A+AAT I RS + + +RPFL FI N Sbjct: 311 GSENLHVSHILQKAKIEVSEDGTKASAATTAILIARS---SPPWFIVDRPFLFFIRHNPT 367 Query: 396 -NILFLGKVNRP 406 +LF+G++N+P Sbjct: 368 GAVLFMGQINKP 379 >5INW-A nrPDB Length = 421 Score = 354 bits (909), Expect = 4e-98, Method: Composition-based stats. Identities = 109/365 (29%), Positives = 185/365 (50%), Gaps = 6/365 (1%) Query: 15 QGASLHRHHPREMKKRVEDLHVGATVAPSSRRDFTFDLYRA-LASAAPSQSIFFSPVSIS 73 +G H + R + S+ F LY+ L A P+ +IFFSP+SI+ Sbjct: 55 KGDEREPHGDEGKRGRKDKKKSKTQRIASAVNGLGFRLYKQVLGGAGPADNIFFSPLSIA 114 Query: 74 MSLAMLSLGAGSSTKMQILEGLGLN--LQKSSEKELHRGFQQLLQELNQPRDGFQLSLGN 131 +L +++ GA ST+ ++ LG L + + + F +L L + GF+L N Sbjct: 115 SALGVVTAGANGSTRAELDTALGFKEFLHGKKKAKSMKYFARLNGALYKRSAGFELMGKN 174 Query: 132 ALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNL 191 +F+ + L F + L+ ++ +F DS A++ +N Y+ K T K D++ ++ Sbjct: 175 VVFSKKGLWLYRQFTRTVAHLFKSNVRSVDFGDSKNAVELMNAYIEKVTSKKFPDVISDV 234 Query: 192 DSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLS 251 D++ +++VN I+FK W F T+ F+V S + VP M + + Y DR L Sbjct: 235 DTDTSLVIVNVIYFKGSWGNKFEPDLTKNVRFWVNSSYSMMVPTMHQRAKLSYTQDRKLR 294 Query: 252 CRVVGVPYQGNATALFILPSEG-KMQQVENGLSEKTLRKWLKMF--KKRQLELYLPKFSI 308 VV +PY+G A+ L I+P + +VE +S++ L +WL + ++L LPKF I Sbjct: 295 STVVKLPYEGGASMLVIVPHRTEDLPKVEESVSQEQLEEWLSLLGPSNHYVQLSLPKFKI 354 Query: 309 EGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGT 368 SY L+ L ++G+S++F+ ADLS I+ + V ++ HK+V+ V+E GT A A T Sbjct: 355 SVSYDLKAYLSAMGMSSMFSYGADLSRITGMQKLHVDKITHKSVLHVNEEGTEAKAETVV 414 Query: 369 IFTFR 373 Sbjct: 415 GIMAA 419 >4DTE-A nrPDB Length = 374 Score = 354 bits (908), Expect = 5e-98, Method: Composition-based stats. Identities = 90/380 (23%), Positives = 184/380 (48%), Gaps = 21/380 (5%) Query: 39 TVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLN 98 + + DF ++ +AP +++ SP I+ L M +GA +T + +G + Sbjct: 1 NLIQDKQTDFGLQVFAEAVQSAPDRNLALSPYGIASVLGMAQMGAYGATLKLLASKMGYS 60 Query: 99 LQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTF 158 LQ+ +L Q+LLQ DG ++ + + D + L+ F ++ + + Sbjct: 61 LQERGMPKL----QRLLQRDLASEDGVEV--ASGVMVDRKIILEKVFRRSLSKAFQSVPH 114 Query: 159 PTNFRDSAGAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHK 216 +F A + IN + + T G I + L + L ++ +N + F W+T F+ + Sbjct: 115 QIDFSQPEMARQVINSWTSDHTDGMISEFLPSGVLSELTRLVFLNALHFHGVWKTPFDPR 174 Query: 217 GTQEQDFYVTSETVVRVPMMSREDQYHYLLD---RNLSCRVVGVPYQGNA-TALFILP-- 270 T+EQ F+ + + V VPMM+ +++Y + V+ +PY+G + + L + P Sbjct: 175 NTREQLFHTVNGSAVSVPMMTTTQKFNYGEFVSKDGVDYDVIEMPYEGESISMLLVTPFE 234 Query: 271 SEGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFT-S 329 + + + LS + +W + +K +L +P+FS++ L+ L +G+ ++F+ S Sbjct: 235 KDVPLSALNKELSSSRIHQWRQEMRKISKQLSIPRFSMDTEIDLKSTLSRMGLGDIFSQS 294 Query: 330 HADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFL 389 AD S I+ + VS+++ + +EV+E GT+ ++AT + +R+ + + +RPF Sbjct: 295 RADFSRITTEEPLCVSKVLQRVKLEVNEEGTKGSSATAAVIY---SRMAVEEITLDRPFF 351 Query: 390 MFIVD---NNILFLGKVNRP 406 I +LF G++ +P Sbjct: 352 FLIQHKPTGALLFSGQLTQP 371 >3F02-A nrPDB Length = 359 Score = 353 bits (906), Expect = 8e-98, Method: Composition-based stats. Identities = 92/347 (26%), Positives = 185/347 (53%), Gaps = 12/347 (3%) Query: 37 GATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLG 96 GAT + D + ++Y L + ++I FSP+SI++++ M+ LGA ST+ +I +G Sbjct: 15 GATFPEEAIADLSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMG 74 Query: 97 LNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLAD 156 + K+ E+ ++ + + + + N+LF + + F+ MK + A Sbjct: 75 YDSLKNGEE--FSFLKEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAA 132 Query: 157 TFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLK--NLDSNAVVIMVNYIFFKAKWETSFN 214 +F + IN +V T + DL+ + D+ + ++N ++FK W++ F Sbjct: 133 VNHVDFSQNVAVANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFR 192 Query: 215 HKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLS------CRVVGVPYQGNA-TALF 267 + T+ F E+ V++PMM ++ +++Y + S +V+ +PY+G+ + + Sbjct: 193 PENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMML 252 Query: 268 ILP-SEGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNV 326 +L E + +E + + + +W KK+++E+YLP+F++E L+ VL +LGI+ + Sbjct: 253 VLSRQEVPLATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEI 312 Query: 327 FTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFR 373 F A+L+G+S++ I +S+ +HK+ +EV+E G+ AAA +G I R Sbjct: 313 FIKDANLTGLSDNKEIFLSKAIHKSFLEVNEEGSEAAAVSGMIAISR 359 >4AJU-A nrPDB Length = 387 Score = 346 bits (888), Expect = 1e-95, Method: Composition-based stats. Identities = 108/330 (32%), Positives = 179/330 (54%), Gaps = 3/330 (0%) Query: 46 RDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEK 105 +F F L R + S ++ FSP +S+++ L LGA T+ QI GL L K ++ Sbjct: 59 SNFGFSLLRKI-SMRHDGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKP 117 Query: 106 ELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDS 165 L + L+E L+ G+ F D+++TF + K + + P NFR++ Sbjct: 118 GLLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNA 177 Query: 166 AGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYV 225 + A + +N Y+ K+T+GKI L ++ +I+V+YI FK KW T F+ T+ F++ Sbjct: 178 SQAKRLMNHYINKETRGKIPKLFDEINPETKLILVDYILFKGKWLTPFDPVFTEVDTFHL 237 Query: 226 TSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSE-GKMQQVENGLSE 284 ++VPMM ++ D+N C V+ +PYQGNAT L +L + G +E+ L+ Sbjct: 238 DKYKTIKVPMMYGAGKFASTFDKNFRCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTT 297 Query: 285 KTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGIS-NHSNIQ 343 + WL+ K R +E++ PKF ++ Y++ ++L +GI +F+ ADLS +S N+Q Sbjct: 298 DLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQ 357 Query: 344 VSEMVHKAVVEVDESGTRAAAATGTIFTFR 373 VS ++ + V+EVDE GT A A + T R Sbjct: 358 VSRVLQRTVIEVDERGTEAVAGILSEITAR 387 >3ZHA-A nrPDB Length = 392 Score = 333 bits (855), Expect = 8e-92, Method: Composition-based stats. Identities = 108/377 (28%), Positives = 191/377 (50%), Gaps = 14/377 (3%) Query: 37 GATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLG 96 AT+A S F LY+A+A ++I SPV ++ SL ++SLG ++T Q L Sbjct: 6 AATLAERSAG-LAFSLYQAMAKDQAVENILLSPVVVASSLGLVSLGGKATTASQAKAVL- 63 Query: 97 LNLQKSSEKELHRGFQQLLQEL-NQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLA 155 + ++ ++E+H G +LL+ L N LG+ L+ V + FV + K Y Sbjct: 64 -SAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFAEDFVRSSKQHYNC 122 Query: 156 DTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNH 215 + NFRD A++ IN++ A+ T GK+ ++ K+++ ++VN +FFK W+ F+H Sbjct: 123 EHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHH 182 Query: 216 KGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFIL-PSEGK 274 K + F VT V V MM R Y+Y D ++V +P ++L IL P + Sbjct: 183 KMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVE 242 Query: 275 -MQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSH-AD 332 ++++E L+++ L+ W+ +K+ + + LPK +E ++ L+K L LG++ + AD Sbjct: 243 PLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKAD 302 Query: 333 LSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFI 392 LS +S ++ ++ + H E D G RS +L + PF+ + Sbjct: 303 LSRMSGKKDLYLASVFHATAFEWDTEGNPFDQDIYGREELRSPKL----FYADHPFIFLV 358 Query: 393 VD---NNILFLGKVNRP 406 D ++LF+G++ RP Sbjct: 359 RDTQSGSLLFIGRLVRP 375 >5NCU-A nrPDB Length = 336 Score = 332 bits (851), Expect = 2e-91, Method: Composition-based stats. Identities = 91/329 (27%), Positives = 160/329 (48%), Gaps = 9/329 (2%) Query: 46 RDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEK 105 F FDL + ++F SP+S+SM+L M GA T ++ L + + Sbjct: 12 NAFAFDLLQTTRKHVTEANVFISPLSVSMALNMTLNGAAGVTADEMKTALRE--TGYTME 69 Query: 106 ELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDS 165 +++ L + L + + + N+++ +++ F+ A +T Y A+ +F Sbjct: 70 DINEYSHSLREALLKVDPSTTIGMANSIWYKQGELVKEPFILANRTHYDAEVKAVDFSSP 129 Query: 166 AGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYV 225 A + IN + A++T KI +L + NA + ++N ++FK W T F T+ F Sbjct: 130 A-TLPAINGWCAQKTNDKITKILDYIPGNAFMYLINAVYFKGIWVTQFKKSDTKRAPFRK 188 Query: 226 TSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFI-LPSEGK-MQQVENGLS 283 T V MM+++ + Y D C+ + + Y A ++ + LP+EG+ + V L Sbjct: 189 ADGTTQEVNMMAQKSTFGYTTDE--CCQYLEMDYGNKAFSMIVMLPNEGQTTRDVIEQLD 246 Query: 284 EKTLRKWLKMFKKRQLELYLPKFSIEGSYQL-EKVLPSLGISNVFTSHADLSGISNHSNI 342 K +K + Q+ L +P+F E Y L +K+LP +G++ FT AD GI++ + I Sbjct: 247 NKHWSMIIKGIRPTQVSLRMPRFKTECKYGLEKKILPEMGMNVPFTETADFPGITDAA-I 305 Query: 343 QVSEMVHKAVVEVDESGTRAAAATGTIFT 371 +S ++HK V+VDE GT AAA T Sbjct: 306 FISRVIHKTFVQVDEEGTEAAAVTAVEMV 334 >1XQJ-A nrPDB Length = 389 Score = 321 bits (824), Expect = 3e-88, Method: Composition-based stats. Identities = 93/378 (24%), Positives = 181/378 (47%), Gaps = 24/378 (6%) Query: 44 SRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSS 103 + F DL++ L+ P ++ FSP+++S SL++ +GA T +I + L + Sbjct: 21 ANSAFAVDLFKQLSEKEPLGNVLFSPIALSTSLSLAQVGAKGDTANEIGQVLHFE----N 76 Query: 104 EKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFR 163 K++ GFQ + ++N+ + L L L+ D ++L F+S+ K Y + +F+ Sbjct: 77 VKDVPFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYAKELETVDFK 136 Query: 164 DS-AGAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQE 220 D QIN+ + T G ++L + ++ +++VN +F KW F+ T+E Sbjct: 137 DKLEETKGQINNSIKDLTDGHFENILADNSVNDQTKILVVNAAYFVGKWMKKFSESETKE 196 Query: 221 QDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFI-LPSE-----GK 274 F V V MM+ E + +++ +++ +P+Q ++FI LP + Sbjct: 197 SPFRVNKTDTKPVQMMNMEATFSMGNIDSINSKIIELPFQNKHLSMFILLPKDVEDESTG 256 Query: 275 MQQVENGLSEKTLRKWLK--MFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSH-A 331 ++++E L+ ++L +W +++L +PKF +E + L +LG+ ++F+ + Sbjct: 257 LEKIEKQLNSESLSQWTNPSTMANAKVKLSIPKFKVEKMIDPKASLENLGLKHIFSEDTS 316 Query: 332 DLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMF 391 D SG+S + +S ++HK +E+ E G + G L + PF+ Sbjct: 317 DFSGMSETKGVALSNVIHKVSLEITEDGGDSIEVPGARILQH-----KDELNADHPFIYI 371 Query: 392 IVDN---NILFLGKVNRP 406 I N NI+F GK + P Sbjct: 372 IRHNKTRNIIFFGKFSSP 389 >2R9Y-A nrPDB Length = 430 Score = 319 bits (818), Expect = 1e-87, Method: Composition-based stats. Identities = 99/371 (26%), Positives = 172/371 (46%), Gaps = 23/371 (6%) Query: 42 PSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQK 101 + FT DL+ +A + S ++ SP+S++++L+ L+LGA + T + L +N Sbjct: 22 AQAMMAFTTDLFSLVAQTSTSSNLVLSPLSVALALSHLALGAQNQTLHSLHRVLHMNTGS 81 Query: 102 SSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTN 161 LL Q + L ++ ++D F+ + L+ A Sbjct: 82 C--------LPHLLSHFYQNLGPGTIRLAARIYLQKGFPIKDDFLEQSERLFGAKPVKLT 133 Query: 162 FRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQ 221 + + IN +V + T+GKI D L L + V++++N I F W T F+ TQ+ Sbjct: 134 GKQEED-LANINQWVKEATEGKIEDFLSELPDSTVLLLLNAIHFHGFWRTKFDPSLTQKD 192 Query: 222 DFYVTSETVVRVPMMS-REDQYHYLLDRNLSCRVVGVPYQGNATALFILPS--EGKMQQV 278 F++ V V MM + L +V P++ N + + ++P+ E + +V Sbjct: 193 FFHLDERFTVSVDMMHAVSYPLRWFLLEQPEIQVAHFPFKNNMSFVVVMPTYFEWNVSEV 252 Query: 279 ENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISN 338 L+ TL + ++R +++LPK ++ L L LG+ +F DL GIS Sbjct: 253 LANLTWDTL--YHPSLQERPTKVWLPKLHLQQQLDLVATLSQLGLQELF-QGPDLRGISE 309 Query: 339 HSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNNI- 397 N+ VS + H++ +E+ E+G AAAAT R++ NRPFL FI+++ I Sbjct: 310 Q-NLVVSSVQHQSTMELSEAGVEAAAATSVAMN----RMSLSSFTVNRPFLFFIMEDTIG 364 Query: 398 --LFLGKVNRP 406 LF+G V P Sbjct: 365 VPLFVGSVRNP 375 >1IMV-A nrPDB Length = 398 Score = 310 bits (794), Expect = 8e-85, Method: Composition-based stats. Identities = 97/377 (25%), Positives = 187/377 (49%), Gaps = 16/377 (4%) Query: 36 VGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGL 95 V ++ +F +DLYR +S +P+ ++ SP+S++ +L+ LSLGA T+ I L Sbjct: 29 VPVNKLAAAVSNFGYDLYRVRSSMSPTTNVLLSPLSVATALSALSLGADERTESIIHRAL 88 Query: 96 GLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLA 155 +L S ++H +++LL + P+ L + + + + ++ +FV+ ++ Y Sbjct: 89 YYDL--ISSPDIHGTYKELLDTVTAPQKN--LKSASRIVFEKKLRIKSSFVAPLEKSYGT 144 Query: 156 DTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNH 215 + +++IN++V Q KGK+ K + ++++ FK +W T F+ Sbjct: 145 RPRVLT-GNPRLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGVAHFKGQWVTKFDS 203 Query: 216 KGTQEQDFYVTSETVVRVPMMSR-EDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEG- 273 + T +DFY+ E VRVPMMS + Y LD +LSC++ +P G+ + +F LP + Sbjct: 204 RKTSLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSIIFFLPLKVT 263 Query: 274 -KMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHAD 332 + +E L+ + + + K Q L +PK + ++ K L + + ++F S D Sbjct: 264 QNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLFDS-PD 322 Query: 333 LSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFI 392 S I+ I+++++ H+A E +E G A T + + N+PF+ + Sbjct: 323 FSKITG-KPIKLTQVEHRAGFEWNEDG---AGTTPSPGLQPAHLTFPLDYHLNQPFIFVL 378 Query: 393 VDNN---ILFLGKVNRP 406 D + +LF+GK+ P Sbjct: 379 RDTDTGALLFIGKILDP 395 >3OZQ-A nrPDB Length = 376 Score = 306 bits (783), Expect = 2e-83, Method: Composition-based stats. Identities = 94/371 (25%), Positives = 183/371 (49%), Gaps = 17/371 (4%) Query: 42 PSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQK 101 P++ FT +Y+ + + + SP S + LA+ G T +I + L Sbjct: 12 PNAVNSFTPSVYKEVLKTEKA-NFLVSPFSAATLLALAQSGCRGDTAEEIRQVLHF---V 67 Query: 102 SSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTN 161 ++ +++L +L + + L N ++ +++ F +Y A + + Sbjct: 68 GDREKAEGAVKEVLSKLT--NEEYTLHTANKIYVKTNFSVREEFQKIAVEVYGAQSENVD 125 Query: 162 FRDSAGAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQ 219 F + A K +N +V +QT+ KI +L+ L++ V+++N ++F AKW F T+ Sbjct: 126 FSEKNDAAKLMNAWVEEQTQHKIQNLVDPEILNNLTRVVLINALYFNAKWLVPFPPFHTR 185 Query: 220 EQDFYVTSETVVRVPMMSREDQ-YHYLLDRNLSCRVVGVPYQGNATALFILPSEGK-MQQ 277 + DF+ +++ VV+V M ++Q ++Y +L +++ +P++G A+ +L ++ + + Sbjct: 186 KSDFHKSAKEVVQVDTMYLDEQYFNYYECHHLDAKLLELPFKGGASLTIVLSNQIEGLVS 245 Query: 278 VENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGIS 337 +E+ + L K+ + + LPKF IE + +KVL LG+ F ADLSGI+ Sbjct: 246 LESKIKRSFLPH---NLTKQLVNVALPKFKIESTVDFKKVLKKLGVKKAFGDEADLSGIA 302 Query: 338 NHS-NIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLN--SQRLVFNRPFLMFI-V 393 ++ +S +V K+ ++V E G AAAAT L ++ + + PF+ +I V Sbjct: 303 GEKGDLVISNIVQKSFIDVSEEGVEAAAATYIPVILPEMALPDSPKQFIVDHPFIFYIKV 362 Query: 394 DNNILFLGKVN 404 ILF G+V Sbjct: 363 KGMILFAGRVT 373 >6CJ7-A nrPDB Length = 390 Score = 304 bits (780), Expect = 4e-83, Method: Composition-based stats. Identities = 107/378 (28%), Positives = 183/378 (48%), Gaps = 16/378 (4%) Query: 38 ATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGL 97 A + + F ++++ +A+ S ++ SP SI++ LAML GA +T +I L + Sbjct: 10 AIHSGPASTSFGVNVFKQMATEQ-SGNLAASPFSITILLAMLQQGAAGNTLDEITRALQM 68 Query: 98 NLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADT 157 +KS+E F+++ +E+ + L N +F +L F + +D Sbjct: 69 TPEKSAEI-----FKKVNEEIQKRNSRNILKTANNVFLSENFNLNPQFKRIAVNNFDSDL 123 Query: 158 FPTNFRDSAGAMKQINDYVAKQTKGKIVDLL--KNLDSNAVVIMVNYIFFKAKWETSFNH 215 PT F A A + IN ++A +T KI L+ +L N ++MVN ++FK WE F Sbjct: 124 TPTYFGKPALAAQNINSWIASKTNDKIDKLVSPDDLSGNTQMVMVNAVYFKGLWEIPFRE 183 Query: 216 KGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALF-ILP-SEG 273 + TQ+++F + M + + +VV +P++ N +L +LP Sbjct: 184 QATQKRNFTLNGGEKKVASFMQTRRYFKAGTHKPAMAKVVVLPFEYNEYSLIVVLPLKSS 243 Query: 274 KMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADL 333 + + + LS + + +L + + L LPKFSI+ LE VL +G+S++FT A+L Sbjct: 244 NVDALLSSLSMEDVASFLD-LPPKDVALELPKFSIKADINLEPVLNKMGVSSIFTQQAEL 302 Query: 334 SGISNHSNI--QVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMF 391 + +H ++ QVS +H AV+ +DE G AAAAT S S N+PFL Sbjct: 303 YNLGSHGSLSPQVSSALHSAVLTIDERGGSAAAATSFAAVALSYDEPSLYFRANKPFLAI 362 Query: 392 IVDNN---ILFLGKVNRP 406 + DN LF+ ++ P Sbjct: 363 LWDNRSSIPLFMARIMDP 380 >3PZF-A nrPDB Length = 397 Score = 299 bits (765), Expect = 2e-81, Method: Composition-based stats. Identities = 92/378 (24%), Positives = 175/378 (46%), Gaps = 22/378 (5%) Query: 46 RDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLS------LG-AGSSTKMQILEGLGLN 98 +F + + + ++ SP S+ + L ++ G A S+TK ++ Sbjct: 23 NEFDLMFVKEIFK-NHNSNVVLSPFSVKILLTLIYEASDTSFGNAVSNTKRELSSV---- 77 Query: 99 LQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTF 158 +Q + ++QLL+ Q + L++ F D +++ + + T Y A Sbjct: 78 IQNDNIDHTRSYYKQLLESAQQDNKDYDLNIATNFFVDDFIEVINKYQQIANTHYHAMLE 137 Query: 159 PTNFRDSAGAMKQINDYVAKQTKGKIVDLL-KNLDSNAVVIMVNYIFFKAKWETSFNHKG 217 ++ + IN++V++ T G++ +++ + AV+ +VN I+FK W F Sbjct: 138 KVSYSNPTQTAATINNWVSEHTNGRLREIVTPDSLEGAVITLVNVIYFKGLWTYPFPEVA 197 Query: 218 TQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATAL-FILPS-EGKM 275 + FY T M + Q++Y +L +++ +PY+GN A+ FILP+ + + Sbjct: 198 NNVKPFYGTRGKPTNAQYMEQNGQFYYDNSADLGAQILRLPYRGNKLAMYFILPNPDNTV 257 Query: 276 QQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLS- 334 QV + ++ +L + L ++ ++ + LPKF + S QL + L +GI +F+ +A L Sbjct: 258 NQVLDRINSASLHQALWYMEENEVNVTLPKFKFDFSEQLNEPLQQVGIREIFSQNASLPL 317 Query: 335 ---GISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMF 391 G ++VS + KA + ++E G+ A AAT + Q NRPF+ F Sbjct: 318 LARGRGARDEVRVSRIFQKAGITINELGSEAYAATEIQLVNKFGGDGVQIFNANRPFIFF 377 Query: 392 IVDNNI---LFLGKVNRP 406 I D + LF GK+ P Sbjct: 378 IEDETLGTMLFAGKIENP 395 >3STO-A nrPDB Length = 406 Score = 298 bits (764), Expect = 2e-81, Method: Composition-based stats. Identities = 95/386 (24%), Positives = 175/386 (45%), Gaps = 22/386 (5%) Query: 43 SSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAML--SLGAGSSTKMQILEGLGLNLQ 100 SS + FT + + + P+ I +L +L S GA T QI + + L Sbjct: 17 SSHKAFTHAYLSTVTADFGGDNFLTCPLGILFTLGILLGSGGAQGRTGYQIGKTMRLKST 76 Query: 101 KSSEK--ELHRGFQQLLQELNQP----------RDGFQLSLGNALFTDLVVDLQDTFVSA 148 SS E + + L QELN ++ + + +F + +++ F + Sbjct: 77 SSSWNSSEAQQEMKSLYQELNNSLTSEKTFLNEKEENVVRISTGIFVEKTYEVERRFNES 136 Query: 149 MKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLL-KNLDSNAVVIMVNYIFFKA 207 + + +F + A IND+V +Q+ G + ++ + +I+VN +F+ Sbjct: 137 IANDSEGELKQVDFSNRTSATVDINDWVDQQSNGLLEKFFTDDIPDDTAMILVNVFYFRD 196 Query: 208 KWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNA-TAL 266 W++ F T+++DFY++ + + V MM++E Y + +V P T + Sbjct: 197 FWQSPFEPHYTRKEDFYISPDRQITVDMMTQEGVMKYGKFEDEGFEIVSKPLNNTRFTFV 256 Query: 267 FILPSE-GKMQQVENGLS-EKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGIS 324 +LP E + L+ K L +++K K+ + L LPKF+++ + L L S+G+ Sbjct: 257 IVLPLEKWSLNGATELLNGNKVLSEYVKNLKETTVSLRLPKFTLKNTLDLVPTLKSIGVV 316 Query: 325 NVFTS-HADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLV 383 ++F +DLSGI+ + N+ V+E + V++++ESG A T IF SA + Sbjct: 317 DLFDPVKSDLSGITPNPNLYVNEFIQTNVLKLNESGIEATTVTSPIFVPFSAIIPEVDFH 376 Query: 384 FNRPFLMFIVDNNI---LFLGKVNRP 406 PF+ FI D + + KV P Sbjct: 377 VTHPFICFIYDQQLTMPIMAAKVMNP 402 >1K9O-I nrPDB Length = 378 Score = 294 bits (753), Expect = 5e-80, Method: Composition-based stats. Identities = 99/377 (26%), Positives = 180/377 (47%), Gaps = 24/377 (6%) Query: 43 SSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGL---NL 99 S FT ++ + A P Q++ S S+ L L+L + + ++L L L N+ Sbjct: 13 ESNDQFTAQMFSEVVKANPGQNVVLSAFSVLPPLGQLALASVGESHDELLRALALPNDNV 72 Query: 100 QKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFP 159 K +L+RG + + G L + + ++ ++L D F + + ++ ++ Sbjct: 73 TKDVFADLNRGVRAV--------KGVDLKMASKIYVAKGLELNDDFAAVSRDVFGSEVQN 124 Query: 160 TNFRDSAGAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKG 217 +F S A IN +V QT +I +L+ LD ++VN I+FK W+ F + Sbjct: 125 VDFVKSVEAAGAINKWVEDQTNNRIKNLVDPDALDETTRSVLVNAIYFKGSWKDKFVKER 184 Query: 218 TQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGN-ATALFILPSEGK-M 275 T ++DF+V+ + ++VP M + Y L +++ + Y+G+ A+ + ILP++ + Sbjct: 185 TMDRDFHVSKDKTIKVPTMIGKKDVRYADVPELDAKMIEMSYEGDQASMIIILPNQVDGI 244 Query: 276 QQVENGL-SEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHA--- 331 +E L K L + + ++E+ LPKF IE + L++VL ++ I +FT A Sbjct: 245 TALEQKLKDPKALSRAEERLYNTEVEITLPKFKIETTTDLKEVLSNMNIKKLFTPGAARL 304 Query: 332 -DLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLM 390 +L + ++ V + KA +EV+E G AAAA +S L + +RPF Sbjct: 305 ENL--LKTKESLTVDAAIQKAFIEVNEEGAEAAAANAFGIVPKSLILYP-EVHIDRPFYF 361 Query: 391 -FIVDNNILFLGKVNRP 406 +D +F GKV P Sbjct: 362 ELKIDGIPMFNGKVIEP 378 >1SEK-A nrPDB Length = 378 Score = 290 bits (743), Expect = 7e-79, Method: Composition-based stats. Identities = 99/377 (26%), Positives = 182/377 (48%), Gaps = 24/377 (6%) Query: 43 SSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGL---NL 99 S FT ++ + A P Q++ S S+ L L+L + + ++L L L N+ Sbjct: 13 ESNDQFTAQMFSEVVKANPGQNVVLSAFSVLPPLGQLALASVGESHDELLRALALPNDNV 72 Query: 100 QKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFP 159 K +L+RG + + G L + + ++ ++L D F + + ++ ++ Sbjct: 73 TKDVFADLNRGVRAV--------KGVDLKMASKIYVAKGLELNDDFAAVSRDVFGSEVQN 124 Query: 160 TNFRDSAGAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKG 217 +F S A IN +V QT +I +L+ LD ++VN I+FK W+ FN + Sbjct: 125 VDFVKSVEAAGAINKWVEDQTNNRIKNLVDPDALDETTRSVLVNAIYFKGSWKDKFNKER 184 Query: 218 TQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGN-ATALFILPSEGK-M 275 T ++DF+V+ + ++VP M + Y L +++ + Y+G+ A+ + ILP++ + Sbjct: 185 TMDRDFHVSKDKTIKVPTMIGKKDVRYADVPELDAKMIEMSYEGDQASMIIILPNQVDGI 244 Query: 276 QQVENGL-SEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHA--- 331 +E L K L + + ++E+YLPKF IE + L++VL ++ I +FT A Sbjct: 245 TALEQKLKDPKALSRAEERLYNTEVEIYLPKFKIETTTDLKEVLSNMNIKKLFTPGAARL 304 Query: 332 -DLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLM 390 +L + ++ V + KA +EV+E G AAAA T S + + N+PF Sbjct: 305 ENL--LKTKESLYVDAAIQKAFIEVNEEGAEAAAANAFKITTYSFHFVPK-VEINKPFFF 361 Query: 391 FI-VDNNILFLGKVNRP 406 + + N +F G +P Sbjct: 362 SLKYNRNSMFSGVCVQP 378 >3LE2-A nrPDB Length = 393 Score = 287 bits (734), Expect = 7e-78, Method: Composition-based stats. Identities = 95/377 (25%), Positives = 178/377 (47%), Gaps = 31/377 (8%) Query: 54 RALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQ 113 + + + + ++ FSP SI++ L++++ G+ +TK QIL L SS +L+ + Sbjct: 22 HVITTVSQNSNVIFSPASINVVLSIIAAGSAGATKDQILSFLKF----SSTDQLNSFSSE 77 Query: 114 LLQEL---NQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSA-GAM 169 ++ + G +LS+ N + D + + +F ++ Y A + +F+ A + Sbjct: 78 IVSAVLADGSANGGPKLSVANGAWIDKSLSFKPSFKQLLEDSYKAASNQADFQSKAVEVI 137 Query: 170 KQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTS 227 ++N + K+T G I ++L DS +I N ++FK W F+ TQE +F++ Sbjct: 138 AEVNSWAEKETNGLITEVLPEGSADSMTKLIFANALYFKGTWNEKFDESLTQEGEFHLLD 197 Query: 228 ETVVRVPMM-SREDQYHYLLDRNLSCRVVGVPY-----QGNATALFILPSEGK-MQQVEN 280 V P M S++ QY D +V+G+PY + + F LP + + + Sbjct: 198 GNKVTAPFMTSKKKQYVSAYD---GFKVLGLPYLQGQDKRQFSMYFYLPDANNGLSDLLD 254 Query: 281 GL--SEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISN 338 + + L + + + E +PKF + VL LG+++ F+ L+ + Sbjct: 255 KIVSTPGFLDNHIPRRQVKVREFKIPKFKFSFGFDASNVLKGLGLTSPFSGEEGLTEMVE 314 Query: 339 HS----NIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVF--NRPFLMFI 392 N+ VS + HKA +EV+E GT AAAA+ + R + + F + PFL+ + Sbjct: 315 SPEMGKNLCVSNIFHKACIEVNEEGTEAAAASAGVIKLRGLLMEEDEIDFVADHPFLLVV 374 Query: 393 VDN---NILFLGKVNRP 406 +N +LF+G+V P Sbjct: 375 TENITGVVLFIGQVVDP 391 >1C8O-A nrPDB Length = 300 Score = 286 bits (731), Expect = 2e-77, Method: Composition-based stats. Identities = 89/324 (27%), Positives = 158/324 (48%), Gaps = 30/324 (9%) Query: 50 FDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHR 109 D++R +AS+ +++F SP SIS L +L GA ST Q+ Sbjct: 1 MDIFREIASSMKGENVFISPPSISSVLTILYYGANGSTAEQLS----------------- 43 Query: 110 GFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAM 169 + + +E ++ +D N ++ +D+F+ + + +F DS + Sbjct: 44 --KYVEKEADKNKDDISFKSMNKVYGRYSAVFKDSFLRKIGDNFQT----VDFTDSR-TV 96 Query: 170 KQINDYVAKQTKGKIVDLLKN-LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSE 228 IN V T+GKI LL L + ++ ++ ++FKAKW F + T + FYV+ Sbjct: 97 DAINKSVDIFTEGKINPLLDEPLSPDTSLLAISAVYFKAKWLMPFEKEFTSDYPFYVSPT 156 Query: 229 TVVRVPMMSREDQ-YHYLLDRN--LSCRVVGVPYQGNATALFILPSE-GKMQQVENGLSE 284 +V V MMS + +++ + + ++ +PY G+ + + ILP ++ +E L++ Sbjct: 157 EMVDVSMMSMYGEAFNHASVKESFGNFSIIELPYVGDTSMVVILPDNIDGLESIEQNLTD 216 Query: 285 KTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQV 344 +KW +++++PKF + GSY L L LG++ VF S D S +SN ++ V Sbjct: 217 TNFKKWSDSMDAMFIDVHIPKFKVTGSYNLVDALVKLGLTEVFGSTGDYSNMSNS-DVSV 275 Query: 345 SEMVHKAVVEVDESGTRAAAATGT 368 M+HK ++V+E T AAAAT Sbjct: 276 DAMIHKTYIDVNEEYTEAAAATSA 299 >2PEF-A nrPDB Length = 373 Score = 281 bits (719), Expect = 4e-76, Method: Composition-based stats. Identities = 101/373 (27%), Positives = 180/373 (48%), Gaps = 24/373 (6%) Query: 44 SRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSS 103 + DF+ +L++ S ++ SP+S ++LAM + GA + T Q+ + LG ++ S Sbjct: 12 NTADFSIELFKN--SIDDKENSLISPLSAMLALAMTANGADNETLAQMEKALGKDI---S 66 Query: 104 EKELHRGFQQLLQELNQPRDGFQLSLGNAL-FTDLVVDLQDTFVSAMKTLYLADTFPTNF 162 ++L++ +++L +L++ N++ F + F+ + Y AD F F Sbjct: 67 IEDLNKYLYTYMKKLPNEEKS-KLTIANSIWFKENDFMPSKDFLQIIADYYKADIFKAAF 125 Query: 163 RDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQD 222 S + IN++V +T G I +L +D V+ ++N + F A+WET + E Sbjct: 126 DSS--TVSDINNWVKSKTNGMIDKILNKIDPEDVMYLINAVAFDAEWETVYEKASVHEDI 183 Query: 223 FYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALF-ILPSEGKMQQVENG 281 F +V M+ E+ + + + PY N + ILP E V Sbjct: 184 FTDVYGNRQKVEFMNSEENLYIEEENAVGF---VKPYAKNHYSFVAILPDEN--ISVNEY 238 Query: 282 LSEKTLRKWLKMFKKRQLEL---YLPKFSIEGSYQLEKVLPSLGISNVF-TSHADLS--G 335 + T +K++ + K ++ L LPKF E + ++ + L SLG+++ F AD S G Sbjct: 239 IKTLTGQKFIDLIKNAKITLVRASLPKFKYEYTIKMNETLESLGMTDAFLPDKADFSKLG 298 Query: 336 ISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDN 395 S+ N+ +SE++HK + VDE GT+A A T T +N + + NRPF+ I+DN Sbjct: 299 KSDIGNLYISEVLHKTFISVDELGTKAGAVTSVDITAAGIPVNFKTVKLNRPFIFAIIDN 358 Query: 396 N---ILFLGKVNR 405 + +F+G V Sbjct: 359 STNLPIFIGTVLS 371 >1SNG-A nrPDB Length = 370 Score = 281 bits (718), Expect = 5e-76, Method: Composition-based stats. Identities = 100/369 (27%), Positives = 162/369 (43%), Gaps = 26/369 (7%) Query: 45 RRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSE 104 +F L+R LA A P + +SP S++ +L +L+ GA ++T+ ++ LG + Sbjct: 14 HLEFALHLHRRLAEAVPDGEVIWSPYSVACALGVLAAGARATTRTELTTLLGTDPAP--- 70 Query: 105 KELHRGFQQLLQELNQP-RDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNF- 162 LL L++ D L+ L+ V ++ +F + M +D +F Sbjct: 71 ---------LLAALDRAVTDSPDLASRTVLWVSADVPVRSSFRATMHDRPDSDVRTADFR 121 Query: 163 RDSAGAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQE 220 + G +N +A T+G I +LL + + I+ N ++ KA+W T F T+ Sbjct: 122 TNPEGVRATVNADIADATRGMIRELLPQGAVTPDLRAILTNALWAKARWTTPFEAHLTRA 181 Query: 221 QDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVEN 280 F T RVP M R Y R R+V + +LP V Sbjct: 182 GTFR-TPRGPKRVPFMHRTKTMPYATARG--WRMVTLHAHDELAVDVLLPPGTNAAAVP- 237 Query: 281 GLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHS 340 + L + +EL LP+F + +QL +VL G+ +FT+ ADLSGIS Sbjct: 238 --TAPLLTALHRRSASTSVELALPRFELTQPHQLVEVLAEAGVRTLFTASADLSGIST-V 294 Query: 341 NIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVF--NRPFLMFI-VDNNI 397 + V ++H+A + VDE G AAAT + A + + F +RPF + + I Sbjct: 295 PLYVDTVIHQARLRVDERGAEGAAATAAMMLLAGAMPPRRTIRFSVDRPFHIVVRRRGAI 354 Query: 398 LFLGKVNRP 406 LFLG + P Sbjct: 355 LFLGSIADP 363 >1JJO-C nrPDB Length = 261 Score = 278 bits (712), Expect = 3e-75, Method: Composition-based stats. Identities = 68/258 (26%), Positives = 140/258 (54%), Gaps = 10/258 (3%) Query: 122 RDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTK 181 + + + L N+LF + + F+ +K + A+ +F + IN +V T Sbjct: 1 ENQYVMKLANSLFVQNGFHVNEEFLQMLKMYFNAEVNHVDFSQNVAVANSINKWVENYTN 60 Query: 182 GKIVDLLKNLDSN--AVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSRE 239 + DL+ D + + ++N ++FK W++ F + T+ F E+ V++PMM ++ Sbjct: 61 SLLKDLVSPEDFDGVTNLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQ 120 Query: 240 DQYHYLLDRNLS------CRVVGVPYQGNATALFILPS--EGKMQQVENGLSEKTLRKWL 291 +++Y + S +V+ +PY+G+ ++ + S E + +E L + + +W Sbjct: 121 GEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLALSRQEVPLATLEPLLKAQLIEEWA 180 Query: 292 KMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKA 351 KK+++E+YLP+F++E L+ +L +LG++ +F A+L+ +S+ + +S+ VHK+ Sbjct: 181 NSVKKQKVEVYLPRFTVEQEIDLKDILKALGVTEIFIKDANLTAMSDKKELFLSKAVHKS 240 Query: 352 VVEVDESGTRAAAATGTI 369 +EV+E G+ AAAA+G I Sbjct: 241 CIEVNEEGSEAAAASGMI 258 >2OAY-A nrPDB Length = 390 Score = 274 bits (700), Expect = 6e-74, Method: Composition-based stats. Identities = 99/385 (25%), Positives = 188/385 (48%), Gaps = 31/385 (8%) Query: 33 DLHVGATVAPSSRRDFTFDLYRALASAAPSQ-SIFFSPVSISMSLAMLSLGAGSSTKMQI 91 + H V + DF+ LY A ++ + ++ FSP SI+ L + LGAG +TK + Sbjct: 24 ESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNL 83 Query: 92 LEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKT 151 L + + +GF ++ + +F + ++DTFV+A +T Sbjct: 84 ESILSYPKDFTCVHQALKGFTT-----------KGVTSVSQIFHSPDLAIRDTFVNASRT 132 Query: 152 LYLADTFPTNFRDSAGA-MKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWE 210 LY + P +++ A ++ IN +VAK T KI LL +L S+ ++++N I+ AKW+ Sbjct: 133 LYSSS--PRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK 190 Query: 211 TSFNHKGTQEQDFYVTSETVVRVPMM-SREDQYHYLLDRNLSCRVVGVPYQGNATALFIL 269 T+F+ K T+ + F+ +V++VPMM S++ + +D+ L +V + N + + ++ Sbjct: 191 TTFDPKKTRMEPFHF-KNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILV 249 Query: 270 PS--EGKMQQVENGLSE---KTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGIS 324 P + +++ +E LS K + + L+M K + L LP+ + S + ++ L Sbjct: 250 PQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFF 309 Query: 325 NVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVF 384 + F+ +L G++ ++QVS M H+ V+E+ E+G + S Sbjct: 310 D-FSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVE-----AAAASAISVARTLLVFEV 363 Query: 385 NRPFLMFIVDNN---ILFLGKVNRP 406 +PFL + D +F+G+V P Sbjct: 364 QQPFLFMLWDQQHKFPVFMGRVYDP 388 >5M3Y-A nrPDB Length = 458 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 86/358 (24%), Positives = 155/358 (43%), Gaps = 26/358 (7%) Query: 66 FFSPVSISMSLAMLSLGAGSSTKMQILEGLGL---NLQKSSEKELHR------GFQQLLQ 116 SP ++ +LA L LGA T ++ LG+ + Q +S + H+ Q LL Sbjct: 100 VLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKQCTSRLDAHKVLSALQAVQGLLV 159 Query: 117 ELNQPRDGFQLSLGN--ALFTDLVVDLQDTFVSAMKTLYLADTFPT--NFRDSAGAMKQI 172 + QL L +FT + L+ FV + LY P +F + A ++I Sbjct: 160 AQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGL-ALYTPVVLPRSLDFTELDVAAEKI 218 Query: 173 NDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVR 232 + ++ T K L ++ + Y+ F+ K + F+ + Q+F+V T V Sbjct: 219 DRFMQAVTGWKTGSSLMGASVDSTLAFNTYVHFQGKMKG-FSL-LAEPQEFWVDQSTSVS 276 Query: 233 VPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPS-EGKMQQVENGLSEKTLRKWL 291 VPM+S + + D V VP+ +A+ L I P + +VE ++ W+ Sbjct: 277 VPMLSGMGTFQHWSDIQDQFSVTQVPFTESASLLLIQPHYASDLDKVEGLTFQQNSLNWM 336 Query: 292 KMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKA 351 K R + L +P+ ++GSY L+ +L + + + +L +SN I+V E+++ Sbjct: 337 KKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDR-IRVGEVLNSI 395 Query: 352 VVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNN---ILFLGKVNRP 406 E++ +T + + + NRPFL + D + + FLG+V P Sbjct: 396 FFELEADEREPTEST-----QQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVANP 448 >1MTP-A nrPDB Length = 323 Score = 254 bits (648), Expect = 7e-68, Method: Composition-based stats. Identities = 85/318 (26%), Positives = 140/318 (44%), Gaps = 23/318 (7%) Query: 45 RRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSE 104 +F L+R LA A P + +SP S++ +L +L+ GA ++T+ ++ LG + Sbjct: 10 HLEFALHLHRRLAEAVPDGEVIWSPYSVACALGVLAAGARATTRTELTTLLGTDPAP--- 66 Query: 105 KELHRGFQQLLQELNQP-RDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNF- 162 LL L++ D L+ L+ V ++ +F + M +D +F Sbjct: 67 ---------LLAALDRAVTDSPDLASRTVLWVSADVPVRSSFRATMHDRPDSDVRTADFR 117 Query: 163 RDSAGAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIMVNYIFFKAKWETSFNHKGTQE 220 + G +N +A T+G I +LL + + I+ N ++ KA+W T F T+E Sbjct: 118 TNPEGVRATVNADIADATRGMIRELLPQGAVTPDLRAILTNALWAKARWTTPFEAHLTRE 177 Query: 221 QDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVEN 280 F T RVP M R Y R R+V + +LP V Sbjct: 178 GTFR-TPRGPKRVPFMHRTKTMPYATARG--WRMVTLHAHDELAVDVLLPPGTNAAAVP- 233 Query: 281 GLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHS 340 + L + +EL LP+F + +QL +VL G+ +FT+ ADLSGIS Sbjct: 234 --TAPLLTALHRRSASTSVELALPRFELTQPHQLVEVLAEAGVRTLFTASADLSGIST-V 290 Query: 341 NIQVSEMVHKAVVEVDES 358 + V ++H+A + VDE Sbjct: 291 PLYVDTVIHQARLRVDER 308 >2WXZ-C nrPDB Length = 453 Score = 252 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 96/403 (23%), Positives = 171/403 (42%), Gaps = 38/403 (9%) Query: 28 KKRVEDLHVGATVAPSSRRDF-TFDLYRALASAAP-SQSIFFSPVSISMSLAMLSLGAGS 85 K ED A VA +F F +Y+ L+ A + SP ++ +L LG+ Sbjct: 61 KLEAEDRQRAAQVAM--IANFMGFRMYKMLSEARGVASGAVLSPPALFGTLVSFYLGSLD 118 Query: 86 STKMQILEGLGLNLQK---SSEKELHR------GFQQLLQELNQPRDGFQLSLGN--ALF 134 T Q+ LG+ +++ +S + H+ Q LL L LF Sbjct: 119 PTASQLQVLLGVPVKEGDCTSRLDGHKVLTALQAVQGLLVTQGGSSSQTPLLQSTVVGLF 178 Query: 135 TDLVVDLQDTFVSAMKTLYLADTFPTNF---RDSAGAMKQINDYVAKQTKGKIVDLLKNL 191 T + L+ FV ++ + FP + D A ++IN +V T K+ L+ + Sbjct: 179 TAPGLRLKQPFVESLGP-FTPAIFPRSLDLSTDPVLAAQKINRFVQAVTGWKMNLPLEGV 237 Query: 192 DSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLS 251 +++ + Y+ F+ K T +F+V + T V VPM+S + + D + Sbjct: 238 STDSTLFFNTYVHFQGKMRGFSQ--LTGLHEFWVDNSTSVSVPMLSGTGNFQHWSDAQNN 295 Query: 252 CRVVGVPYQGNATALFILP-SEGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEG 310 V VP + T L I P + +VE + + W+K R + L LP+ I G Sbjct: 296 FSVTRVPLGESVTLLLIQPQCASDLDRVEVLVFQHDFLTWIKNPPPRAIRLTLPQLEIRG 355 Query: 311 SYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEV----DESGTRAAAAT 366 SY L+ +L +S + + A+L + +N +V E+++ ++E+ +E T +A Sbjct: 356 SYNLQDLLAQAKLSTLLGAEANLGKM-GDTNPRVGEVLNSILLELQAGEEEQPTESAQQP 414 Query: 367 GTIFTFRSARLNSQRLVFNRPFLMFIVDNN---ILFLGKVNRP 406 G+ + + PFL I + + + FLG+V+ P Sbjct: 415 GSPEVL--------DVTLSSPFLFAIYERDSGALHFLGRVDNP 449 >2WXX-A nrPDB Length = 453 Score = 252 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 94/406 (23%), Positives = 173/406 (42%), Gaps = 30/406 (7%) Query: 23 HPREM--KKRVEDLHVGATVAPSSRRDF-TFDLYRALASAAPSQS-IFFSPVSISMSLAM 78 H + + +++ED + +F F +Y+ L A S SP ++ +L Sbjct: 52 HDQLVLAAEKLEDEDRKRAAQVAMITNFVGFRMYKMLNEAGSGASGAILSPPALFGTLVS 111 Query: 79 LSLGAGSSTKMQILEGLGLNLQK---SSEKELHR------GFQQLLQELNQPRDGFQL-- 127 LG+ T Q+ L + +++ +S + H+ Q LL L Sbjct: 112 FYLGSLDPTASQLQTLLDVPVKEGDCTSRLDGHKVLAALRAVQGLLVTQGGSSSQTPLLQ 171 Query: 128 SLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNF---RDSAGAMKQINDYVAKQTKGKI 184 S+ LFT L+ +FV ++ L+ FP + D A ++IN ++ T K+ Sbjct: 172 SIVVGLFTAPGFRLKHSFVQSL-ALFTPALFPRSLDLSTDPVLATEKINRFIKAVTGWKM 230 Query: 185 VDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHY 244 L+ + +++ ++ Y+ F+ G E F+V + V VPM+S + + Sbjct: 231 NLPLEGVSTDSTLLFNTYVHFQGTMRGFSQLPGVHE--FWVDNSISVSVPMISGTGNFQH 288 Query: 245 LLDRNLSCRVVGVPYQGNATALFILPS-EGKMQQVENGLSEKTLRKWLKMFKKRQLELYL 303 D + V VP AT L I P + +VE + + L W++ R + L L Sbjct: 289 WSDAQNNFSVTCVPLGERATLLLIQPHCISDLDRVEALIFQNDLLTWIENPPPRAIRLTL 348 Query: 304 PKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAA 363 P+ I GSY L+ +L + + + A+L+ I +N +V E+++ ++E+ ++G Sbjct: 349 PQLEIRGSYNLQDLLAEDKLPTLLGAEANLNNI-GDTNPRVGEVLNSILLEL-KAGEEEQ 406 Query: 364 AATGTIFTFRSARLNSQRLVFNRPFLMFIVDNN---ILFLGKVNRP 406 T L + + PFL I + + + FLG+VN P Sbjct: 407 PTTSVQQPGSPEAL---DVTLSSPFLFAIYEQDSGTLHFLGRVNNP 449 >6BJ5-B nrPDB Length = 315 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 80/334 (23%), Positives = 147/334 (44%), Gaps = 34/334 (10%) Query: 40 VAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNL 99 + + RD +R + S ++ FSP ++ +L++L + AG +TK +I Sbjct: 10 LTSCACRDIGLWTFRYVY--NESDNVVFSPYGLTSALSVLRIAAGGNTKREID------- 60 Query: 100 QKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFP 159 S E F L + LF D V L+ F + + + Sbjct: 61 VPESVVEDSDAFLALRE----------------LFVDASVPLRPEFTAEFSSRFNTSVQR 104 Query: 160 TNFRDSAGAMKQINDYVAKQTKGKIVDLLK-NLDSNAVVIMVNYIFFKAKWETSFNHKGT 218 F +S IN YV +T G + +L +LD + +++++ + K W F+ T Sbjct: 105 VTF-NSENVKDVINSYVKDKTGGDVPRVLDASLDRDTKMLLLSSVRMKTSWRHVFDPSFT 163 Query: 219 QEQDFYVTSETVVRVPMMSREDQYHY--LLDRNLSCRVVGVPYQGNAT-ALFILPSEGKM 275 +Q FY + +V MM++ D RN+ V +PY+ T L ++P + + Sbjct: 164 TDQPFY-SGNVTYKVRMMNKIDTLKTETFTLRNVGYSVTELPYKRRQTAMLLVVPDD--L 220 Query: 276 QQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFT-SHADLS 334 ++ L +R W++ +K ++ +PKFS+E L L LG+ + F S AD Sbjct: 221 GEIVRALDLSLVRFWIRNMRKDVCQVVMPKFSVESVLDLRDALQRLGVRDAFDPSRADFG 280 Query: 335 GISNHSNIQVSEMVHKAVVEVDESGTRAAAATGT 368 S +++ V++++ + +E DE GT A++ T Sbjct: 281 QASPSNDLYVTKVLQTSKIEADERGTTASSDTAI 314 >1M93-B nrPDB Length = 245 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 70/250 (28%), Positives = 124/250 (49%), Gaps = 11/250 (4%) Query: 124 GFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGK 183 N ++ +D+F+ + + +F DS + IN V T+GK Sbjct: 1 DISFKSMNKVYGRYSAVFKDSFLRKIGDNFQT----VDFTDSR-TVDAINKSVDIFTEGK 55 Query: 184 IVDLLKN-LDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQ- 241 I LL L + ++ ++ ++FKAKW F + T + FYV+ +V V MMS + Sbjct: 56 INPLLDEPLSPDTSLLAISAVYFKAKWLMPFEKEFTSDYPFYVSPTEMVDVSMMSMYGEA 115 Query: 242 YHYLLDRN--LSCRVVGVPYQGNATALFILPSE-GKMQQVENGLSEKTLRKWLKMFKKRQ 298 +++ + + ++ +PY G+ + + ILP ++ +E L++ +KW Sbjct: 116 FNHASVKESFGNFSIIELPYVGDTSMVVILPDNIDGLESIEQNLTDTNFKKWSDSMDAMF 175 Query: 299 LELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDES 358 +++++PKF + GSY L L LG++ VF S D S +SN ++ V M+HK ++V+E Sbjct: 176 IDVHIPKFKVTGSYNLVDALVKLGLTEVFGSTGDYSNMSNS-DVSVDAMIHKTYIDVNEE 234 Query: 359 GTRAAAATGT 368 T AAAAT Sbjct: 235 YTEAAAATSA 244 >5C98-A nrPDB Length = 382 Score = 237 bits (605), Expect = 6e-63, Method: Composition-based stats. Identities = 77/378 (20%), Positives = 151/378 (39%), Gaps = 37/378 (9%) Query: 43 SSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKM--QILEGLGLNLQ 100 ++ FT + ++A + ++ SP + ++L+M AG++ + Q+ GL ++ Sbjct: 19 AANNKFTLEYFKACYDEKCNCAV--SPYHVRLALSMFYPLAGAAVQEDFQVAFGLPEDVH 76 Query: 101 KSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPT 160 + E++ Q+L Q+L+ DG L + + + + L F + P Sbjct: 77 AAIEQQ-----QRLAQQLH---DGQHLKALSFVLVEETLRLDSEFERLFHRTFQTTVEPV 128 Query: 161 NFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKA-----KWETSFNH 215 + D + +N + ++ +I D + D ++ + F FN Sbjct: 129 DLTDDIPSALAVNSFY-QRANTEIEDFIGEGDVFSLPPCHKLMLFSGVSVLTPLAIRFNP 187 Query: 216 KGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQG--NATALFILPSEG 273 T + F + RV M L L C+VV +P+ + L +LP +G Sbjct: 188 ADTALELFQFINAPTQRVSTMHTTAFVRRCLHNELRCKVVDMPFDAASGLSMLVLLPYDG 247 Query: 274 -KMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHAD 332 +++Q+ N ++ L + + + +L LPKF + ++ L LG VF D Sbjct: 248 TELRQIVNSITPAHLAQIDERLQSCWTDLKLPKFFVREKTDPKQTLGKLGYGGVFEID-D 306 Query: 333 LSGISNHSNIQVSEMVHKAVVEVDESGT--RAAAATGTIFTFRSARLNSQRLVFNRPFLM 390 L + +++ + + V ESG+ A T + F NRPF+ Sbjct: 307 LHVFHDSGRTRLNGFIQHCYLAVSESGSGIPAPPDTPSEF----------EFHANRPFMF 356 Query: 391 FIV---DNNILFLGKVNR 405 I D N+L +G ++ Sbjct: 357 LIRRTMDGNVLQVGNFSK 374 >4R9I-A nrPDB Length = 378 Score = 97.3 bits (241), Expect = 1e-20, Method: Composition-based stats. Identities = 74/399 (18%), Positives = 143/399 (35%), Gaps = 36/399 (9%) Query: 22 HHPREMKKRVEDLHVGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSL 81 HH M K + + A + D P ++ F + + L+ LSL Sbjct: 1 HHHHHMTKNYTEAQLKYYDANTGLCGIGID---QWFQYEPERNQFSTAFPLLFMLSELSL 57 Query: 82 GAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDL 141 + T + L NL SE E+ Q + LN + +Q +L +TD+ Sbjct: 58 NSKEDTTAE----LYKNLNLRSEDEVVNVNQAVNTNLNTKNEVYQSTLILNAYTDIDSPF 113 Query: 142 QDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKN--LDSNAVVIM 199 +TF+ ++ ++ + A+ I D + + I LK+ ++ + +I+ Sbjct: 114 SETFIQNFAKVFNGTVKNIDYSN--DAVATIRDSLQSDSGNDIEIALKDGDINKDTGIIL 171 Query: 200 VNY--IFFKAKWETSFNHKGTQEQ---DFYVTSETVVRVPMMSREDQYHYLLDRNLSCRV 254 Y I+F W + + +Q F T E Y NL +V Sbjct: 172 TAYTNIYF--PWGEASDSYRPYKQIDISFTALDGTQSNKQAWYSEGAGKYAEIENLGIKV 229 Query: 255 VGVPYQGNATALF--ILPSEGKMQQVENGL-SEKTLRKWLKMFKKRQLELYLP-KFSIEG 310 + T + L + N L TL L + + L+L +P + ++ Sbjct: 230 FQFSLKPGLTVVLGTSLNDNNDLSGAFNKLRDPATLAYILTQTESKYLKLAVPIELTMRD 289 Query: 311 SYQLEKVLPSLGI-SNVFTSHAD-LSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGT 368 S + G+ + +F + D + ++ + +S M+ +E E T AA+ Sbjct: 290 SRDYIPEVKRAGLLTELFEKNFDGFDTVYDNKSGYISYMLSHTRLEF-EQPTEEQAASVV 348 Query: 369 IFTFRSARLNSQRLVFNRPFLMFIVD--NNILFLGKVNR 405 +F++P+ ++D N F+G + Sbjct: 349 ---------AEPDFIFDKPYFFLVLDQFNTPAFIGLITN 378 >5NSQ-A nrPDB Length = 521 Score = 31.0 bits (69), Expect = 0.92, Method: Composition-based stats. Identities = 12/69 (17%), Positives = 19/69 (27%), Gaps = 11/69 (15%) Query: 327 FTSHA--DLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIF-------TFRSARL 377 FT D++ ++ I H A + V+E G AA Sbjct: 391 FTPDVVIDMATLTGAQGIATGR--HHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEY 448 Query: 378 NSQRLVFNR 386 + N Sbjct: 449 HEPEFKSNH 457 >4P2L-A nrPDB Length = 506 Score = 31.0 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 24/71 (33%), Gaps = 22/71 (30%) Query: 137 LVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAV 196 + FV+ + + NF + IND++ KQ K KI Sbjct: 285 QRLVALKKFVAVLAKYFPGQPLVQNF------LHSINDWLQKQQKKKIP----------- 327 Query: 197 VIMVNYIFFKA 207 Y +FKA Sbjct: 328 -----YSYFKA 333 >3DO6-A nrPDB Length = 543 Score = 29.9 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 17/109 (15%), Positives = 38/109 (34%), Gaps = 2/109 (1%) Query: 11 LLSPQGASLHRHHPREMKKRVEDLHVGATVA-PSSRRDFTFDLYRALASAAPSQSIF-FS 68 ++ G S + + V A +A + +D L + + + + I S Sbjct: 166 IVIGLGGSANGFPREDSFIITAASEVMAILALSENMKDLKERLGKIIVALDADRKIVRIS 225 Query: 69 PVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLLQE 117 + I ++A+L A + +Q EG + + G ++ Sbjct: 226 DLGIQGAMAVLLKDAINPNLVQTTEGTPALIHCGPFANIAHGTNSIIAT 274 >3H1Q-A nrPDB Length = 272 Score = 29.9 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 9/43 (20%), Positives = 15/43 (34%), Gaps = 4/43 (9%) Query: 181 KGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDF 223 KGKI + +V ++ F T ++DF Sbjct: 158 KGKITATFDEPTGGTHLSLVLA----GSYKIPFEEAETIKKDF 196 >5NSS-F nrPDB Length = 295 Score = 29.5 bits (65), Expect = 2.4, Method: Composition-based stats. Identities = 13/71 (18%), Positives = 25/71 (35%) Query: 234 PMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLSEKTLRKWLKM 293 P M E + L L+ VV +P + +L +E Q+ + + + Sbjct: 173 PAMVNEGTFRADLLDRLAFDVVQLPPLRERESDIMLMAEYFAIQMCREIKLPLFPGFTER 232 Query: 294 FKKRQLELYLP 304 ++ L P Sbjct: 233 ARETLLNYRWP 243 >2C98-A nrPDB Length = 265 Score = 29.5 bits (65), Expect = 2.4, Method: Composition-based stats. Identities = 13/71 (18%), Positives = 25/71 (35%) Query: 234 PMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLSEKTLRKWLKM 293 P M E + L L+ VV +P + +L +E Q+ + + + Sbjct: 153 PAMVNEGTFRADLLDRLAFDVVQLPPLRERESDIMLMAEYFAIQMCREIKLPLFPGFTER 212 Query: 294 FKKRQLELYLP 304 ++ L P Sbjct: 213 ARETLLNYRWP 223 >3T59-A nrPDB Length = 519 Score = 29.1 bits (64), Expect = 3.7, Method: Composition-based stats. Identities = 11/49 (22%), Positives = 19/49 (38%), Gaps = 6/49 (12%) Query: 137 LVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIV 185 + FV+ + + NF + IND++ KQ K +I Sbjct: 297 QRLVALKKFVAVLAKYFPGQPLVQNF------LHSINDWLQKQQKKRIP 339 >5U6P-A nrPDB Length = 660 Score = 29.1 bits (64), Expect = 3.9, Method: Composition-based stats. Identities = 16/78 (20%), Positives = 31/78 (39%), Gaps = 9/78 (11%) Query: 132 ALFTDLVVDLQDTFVSAMKTLYLADTFPT----NFRD-SAGAMKQINDYVAKQTKGKI-- 184 A+F L + + + + Y +F A ++I+DY + +GKI Sbjct: 387 AMFVGHATALIQS-LDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFD 445 Query: 185 -VDLLKNLDSNAVVIMVN 201 ++L L+ +VN Sbjct: 446 EENILNELNDPLREEIVN 463 >1F2V-A nrPDB Length = 219 Score = 28.7 bits (63), Expect = 4.4, Method: Composition-based stats. Identities = 11/38 (28%), Positives = 16/38 (42%) Query: 46 RDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGA 83 D + A S ++ FSP +S + A L GA Sbjct: 44 ADLAVRMVHACGSVEATRQFVFSPDFVSSARAALKAGA 81 >5W76-A nrPDB Length = 385 Score = 28.7 bits (63), Expect = 5.1, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 17/42 (40%), Gaps = 3/42 (7%) Query: 353 VEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVD 394 +E DE G A + + + ++PFLM I D Sbjct: 171 LEGDEEGEEA---IMKLMDAVDSYIPEPERAIDKPFLMPIED 209 >2I0Q-B nrPDB Length = 385 Score = 27.9 bits (61), Expect = 7.6, Method: Composition-based stats. Identities = 20/145 (13%), Positives = 36/145 (24%), Gaps = 19/145 (13%) Query: 102 SSEKELHRGFQQLLQELNQPRDGFQLSLGN-----ALFTDLVVD----------LQDTFV 146 +S + F+QL EL F N + + F Sbjct: 5 ASAPQQQSAFKQLYTELFNNEGDFSKVSSNLKKPLKCYVKESYPHFLVTDGYFFVAPYFT 64 Query: 147 SAMKTLYLADTFPTNFRDSAGAMKQINDY-VAKQTKGKIVDLLKNLDSNAVVIMVNYIFF 205 + A N D + IN++ + + + A +I+ + F Sbjct: 65 KEAVNEFHAKFPNVNIVDLTDKVIVINNWSLELRRVNSAEVFTSYANLEARLIVHS---F 121 Query: 206 KAKWETSFNHKGTQEQDFYVTSETV 230 K + N F Sbjct: 122 KPNLQERLNPTRYPVNLFRDDEFKT 146 >5MRJ-A nrPDB Length = 396 Score = 27.6 bits (60), Expect = 9.9, Method: Composition-based stats. Identities = 13/69 (18%), Positives = 23/69 (33%), Gaps = 6/69 (8%) Query: 125 FQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDY------VAK 178 + N +F++ F + ++ F A INDY AK Sbjct: 214 VHWDVVNEIFSEDGNLRDSVFSRVLGEDFVGIAFRAARAADPNAKLYINDYNLDNANYAK 273 Query: 179 QTKGKIVDL 187 T+G + + Sbjct: 274 VTRGMVEKV 282 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.149 0.431 Lambda K H 0.267 0.0455 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,083,094 Number of Sequences: 36641 Number of extensions: 649012 Number of successful extensions: 2412 Number of sequences better than 10.0: 78 Number of HSP's better than 10.0 without gapping: 123 Number of HSP's successfully gapped in prelim test: 27 Number of HSP's that attempted gapping in prelim test: 1814 Number of HSP's gapped (non-prelim): 155 length of query: 406 length of database: 10,336,785 effective HSP length: 99 effective length of query: 307 effective length of database: 6,709,326 effective search space: 2059763082 effective search space used: 2059763082 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (28.0 bits)