BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P05108 (521 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3N9Z-A nrPDB 1000 0.0 3MZS-A nrPDB 759 0.0 4ZGX-A nrPDB 332 3e-91 6M7X-A nrPDB 321 5e-88 3K9V-A nrPDB 219 3e-57 5VEU-A nrPDB 102 4e-22 6DA2-A nrPDB 101 6e-22 6B82-A nrPDB 92 4e-19 5YLW-A nrPDB 91 9e-19 4R1Z-A nrPDB 91 1e-18 4R20-A nrPDB 83 3e-16 6C94-A nrPDB 80 2e-15 6IQ5-A nrPDB 79 3e-15 2VE3-A nrPDB 79 6e-15 5FSA-A nrPDB 76 4e-14 3QZ1-A nrPDB 75 5e-14 2PG7-A nrPDB 72 4e-13 3DL9-A nrPDB 72 4e-13 5VBU-A nrPDB 72 7e-13 5W0C-A nrPDB 70 2e-12 2NNH-A nrPDB 70 2e-12 4GQS-A nrPDB 70 2e-12 4H1N-A nrPDB 69 7e-12 1N6B-A nrPDB 68 7e-12 3EL3-A nrPDB 67 2e-11 3MDV-A nrPDB 67 2e-11 2X2N-A nrPDB 66 3e-11 2HI4-A nrPDB 66 4e-11 6DWN-A nrPDB 66 4e-11 2WX2-A nrPDB 65 5e-11 3L4D-A nrPDB 65 7e-11 3E6I-A nrPDB 64 2e-10 5UYS-A nrPDB 62 4e-10 2W0A-A nrPDB 62 7e-10 3R9C-A nrPDB 62 8e-10 6AYB-A nrPDB 61 1e-09 5JLC-A nrPDB 59 6e-09 3TBG-A nrPDB 59 6e-09 1CPT-A nrPDB 59 7e-09 3S79-A nrPDB 58 8e-09 3IBD-A nrPDB 57 2e-08 4WMZ-A nrPDB 57 2e-08 5E0E-A nrPDB 57 3e-08 5E58-A nrPDB 56 3e-08 4GGV-A nrPDB 56 3e-08 3MGX-A nrPDB 56 3e-08 6B11-A nrPDB 56 3e-08 3A1L-A nrPDB 55 6e-08 2WIY-A nrPDB 55 6e-08 6GK6-A nrPDB 54 1e-07 3SN5-A nrPDB 53 3e-07 3NC3-A nrPDB 53 4e-07 1WIY-A nrPDB 52 4e-07 4Z5P-A nrPDB 52 5e-07 1UE8-A nrPDB 52 6e-07 5VWS-A nrPDB 51 1e-06 5CJE-A nrPDB 51 1e-06 6F0B-A nrPDB 50 2e-06 3JUS-A nrPDB 50 2e-06 1ODO-A nrPDB 50 2e-06 4YZR-A nrPDB 49 4e-06 1UED-A nrPDB 49 4e-06 5FOI-A nrPDB 49 4e-06 4UBS-A nrPDB 49 5e-06 3TYW-A nrPDB 49 5e-06 2Y5N-A nrPDB 49 6e-06 3TKT-A nrPDB 49 6e-06 4JBT-A nrPDB 49 7e-06 2WIO-A nrPDB 48 1e-05 1Z8P-A nrPDB 48 1e-05 2VZM-A nrPDB 47 2e-05 6GII-A nrPDB 47 2e-05 2FR7-A nrPDB 47 2e-05 6CR2-A nrPDB 47 2e-05 6GMF-A nrPDB 47 2e-05 2RFC-A nrPDB 47 3e-05 6HQW-A nrPDB 46 3e-05 5NWS-A nrPDB 46 3e-05 4WPZ-A nrPDB 46 4e-05 6A7J-A nrPDB 46 5e-05 3ABB-A nrPDB 45 5e-05 3P3Z-A nrPDB 45 7e-05 5XW2-A nrPDB 45 8e-05 6A7I-A nrPDB 45 9e-05 4OQR-A nrPDB 45 9e-05 1EHE-A nrPDB 45 1e-04 6HQG-A nrPDB 45 1e-04 5LIE-A nrPDB 45 1e-04 2ZBZ-A nrPDB 45 1e-04 3A50-A nrPDB 45 1e-04 4OQS-A nrPDB 45 1e-04 3WVS-A nrPDB 44 1e-04 4DO1-A nrPDB 44 1e-04 4RM4-A nrPDB 44 1e-04 5IT1-A nrPDB 44 1e-04 3RWL-A nrPDB 44 2e-04 5HDI-A nrPDB 44 2e-04 4TRI-A nrPDB 43 3e-04 1Q5D-A nrPDB 43 3e-04 5EX6-C nrPDB 43 4e-04 5YSW-A nrPDB 43 4e-04 2XKR-A nrPDB 43 4e-04 5FYF-A nrPDB 43 4e-04 3OFT-A nrPDB 43 4e-04 2NZA-A nrPDB 42 4e-04 5L1U-A nrPDB 42 5e-04 5L94-A nrPDB 42 6e-04 3EJB-B nrPDB 42 6e-04 3ABA-A nrPDB 42 6e-04 6G71-A nrPDB 42 7e-04 1GWI-A nrPDB 42 8e-04 6HQD-A nrPDB 41 0.001 4MM0-A nrPDB 41 0.002 5OFQ-A nrPDB 40 0.002 1F4U-A nrPDB 40 0.002 5XJN-A nrPDB 40 0.002 5GWE-A nrPDB 40 0.003 4PWV-A nrPDB 40 0.003 5EX8-A nrPDB 40 0.003 5DE9-A nrPDB 40 0.003 5Z9I-A nrPDB 39 0.004 4FB2-A nrPDB 39 0.006 5Y1I-A nrPDB 39 0.006 5HH3-A nrPDB 39 0.006 2WM5-A nrPDB 38 0.010 2Z36-A nrPDB 37 0.014 5D3U-A nrPDB 36 0.033 5H1Z-A nrPDB 36 0.034 2IAG-A nrPDB 36 0.041 6DCD-A nrPDB 35 0.084 3BUJ-A nrPDB 35 0.093 6CVC-A nrPDB 35 0.10 5HIW-A nrPDB 34 0.15 5YHJ-A nrPDB 33 0.20 1LG9-A nrPDB 33 0.22 2X9P-A nrPDB 33 0.24 6FSH-A nrPDB 33 0.32 4C9K-A nrPDB 33 0.32 4TX3-A nrPDB 33 0.40 3OO3-A nrPDB 32 0.49 6M7L-A nrPDB 32 0.74 4XE3-A nrPDB 32 0.89 5CLR-A nrPDB 31 1.2 2YJN-B nrPDB 30 2.2 2X44-D nrPDB 30 2.7 6G5O-A nrPDB 30 3.6 3MPG-A nrPDB 29 5.1 1KA4-A nrPDB 29 5.2 3AWQ-A nrPDB 29 5.2 3TB2-A nrPDB 28 7.1 4KVO-A nrPDB 28 7.7 >3N9Z-A nrPDB Length = 487 Score = 1000 bits (2586), Expect = 0.0, Method: Compositional matrix adjust. Identities = 481/481 (100%), Positives = 481/481 (100%) Query: 41 STRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVY 100 STRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVY Sbjct: 1 STRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVY 60 Query: 101 VIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMA 160 VIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMA Sbjct: 61 VIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMA 120 Query: 161 PEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQG 220 PEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQG Sbjct: 121 PEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQG 180 Query: 221 MLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIY 280 MLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIY Sbjct: 181 MLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIY 240 Query: 281 TQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLY 340 TQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLY Sbjct: 241 TQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLY 300 Query: 341 EMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVN 400 EMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVN Sbjct: 301 EMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVN 360 Query: 401 DLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVR 460 DLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVR Sbjct: 361 DLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVR 420 Query: 461 QCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQ 520 QCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQ Sbjct: 421 QCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQ 480 Query: 521 Q 521 Q Sbjct: 481 Q 481 >3MZS-A nrPDB Length = 486 Score = 759 bits (1959), Expect = 0.0, Method: Compositional matrix adjust. Identities = 353/480 (73%), Positives = 418/480 (87%), Gaps = 1/480 (0%) Query: 41 STRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVY 100 ST++PRP++EIPSPGDNGWLNLYHFWRE G+ ++H H++NFQKYGPIYREKLGN+ESVY Sbjct: 3 STKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVY 62 Query: 101 VIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMA 160 +I PEDVA LFK EG PER+ IPPW+AYH+YYQ+PIGVL KKS WKKDRV LN EVMA Sbjct: 63 IIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMA 122 Query: 161 PEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQG 220 PEA KNF+PLL+ VS+DFVS+LH+RIK+ GSG + GDI +DLF FAFESITNV+FGER G Sbjct: 123 PEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLG 182 Query: 221 MLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIY 280 MLEE VNPEAQ+FIDA+Y+MFHTSVP+LN+PP+L+RLFRTKTW+DHVAAWD IF+KA+ Y Sbjct: 183 MLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKY 242 Query: 281 TQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLY 340 T+ FY +LR+K +Y GILY LL KM ED+KAN+TEMLAGGV+TTSMTLQWHLY Sbjct: 243 TEIFYQDLRRKTEF-RNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLY 301 Query: 341 EMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVN 400 EMAR+L VQ+MLR EVL AR QA+GD++ MLQ+VPLLKASIKETLRLHPISVTLQRY + Sbjct: 302 EMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPES 361 Query: 401 DLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVR 460 DLVL+DY+IPAKTLVQVAIYA+GR+P FF P+ FDPTRWLSKDK++ +FRNLGFGWGVR Sbjct: 362 DLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVR 421 Query: 461 QCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQ 520 QC+GRRIAELEMT+FLI++LENF+VE+QH+ DV T FNLIL P+KPI F PFNQ+ Q Sbjct: 422 QCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQDPPQ 481 >4ZGX-A nrPDB Length = 489 Score = 332 bits (851), Expect = 3e-91, Method: Compositional matrix adjust. Identities = 189/481 (39%), Positives = 275/481 (57%), Gaps = 5/481 (1%) Query: 38 AGISTRSPR---PFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLG 94 A + R+PR PF +P N WL L WRE G +HL Q FQ+ GPI+R LG Sbjct: 2 ATKAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLG 61 Query: 95 NVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVAL 154 V V+ PEDV L + + +P R ++ PWVAY Q+ GV L W+ +R+ L Sbjct: 62 GPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRL 121 Query: 155 NQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVI 214 N +V++P+A + FLP++DAV+RDF L +++ + G+ + D+ +F + E+ + Sbjct: 122 NPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL 181 Query: 215 FGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIF 274 FGER G++ + + F+ A+ MF ++V ++ +P L R K WK+H AWD IF Sbjct: 182 FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIF 241 Query: 275 SKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMT 334 D Q Y EL H Y GI+ LL +++S E IKAN E+ AG VDTT+ Sbjct: 242 QYGDNCIQKIYQELAFNRPQH--YTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFP 299 Query: 335 LQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTL 394 L L+E+ARN VQ +LR E LAA +PLL+A++KETLRL+P+ + L Sbjct: 300 LLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 359 Query: 395 QRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLG 454 +R + +DLVL++Y IPA TLVQV +Y+LGR F PE ++P RWL + F ++ Sbjct: 360 ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVP 419 Query: 455 FGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPF 514 FG+G+RQCLGRR+AE EM + L ++L++F VE D+ ++ IL P TF Sbjct: 420 FGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAI 479 Query: 515 N 515 N Sbjct: 480 N 480 >6M7X-A nrPDB Length = 484 Score = 321 bits (822), Expect = 5e-88, Method: Compositional matrix adjust. Identities = 184/474 (38%), Positives = 267/474 (56%), Gaps = 2/474 (0%) Query: 43 RSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVI 102 R+ PF +P N WL L WRE G +HL Q FQ+ GPI+R LG V V+ Sbjct: 10 RTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVM 69 Query: 103 DPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPE 162 PEDV L + + +P R + PWVAY Q+ GV L W+ +R+ LN EV++P Sbjct: 70 LPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPN 129 Query: 163 ATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGML 222 A + FLP++DAV+RDF L +++ + G+ + D+ +F + E+ +FGER G++ Sbjct: 130 AVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLV 189 Query: 223 EEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQ 282 + + F+ A+ MF ++V ++ +P L R K WK+H AWD IF D Q Sbjct: 190 GHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQ 249 Query: 283 NFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEM 342 Y EL S Y I+ LL ++++S + IKAN E+ AG VDTT L L+E+ Sbjct: 250 KIYQEL--AFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFEL 307 Query: 343 ARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDL 402 ARN VQ LR E LAA +PLL+A++KETLRL+P+ + L+R +DL Sbjct: 308 ARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDL 367 Query: 403 VLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQC 462 VL++Y IPA TLV+V +Y+LGR P F PE ++P RWL + F ++ FG+G+RQC Sbjct: 368 VLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQC 427 Query: 463 LGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQ 516 LGRR+AE EM + L ++L++ +VE D+ ++ IL P TF N Sbjct: 428 LGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAINH 481 >3K9V-A nrPDB Length = 482 Score = 219 bits (557), Expect = 3e-57, Method: Compositional matrix adjust. Identities = 143/470 (30%), Positives = 231/470 (49%), Gaps = 11/470 (2%) Query: 46 RPFNEIPSPGDNGWLN--LYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVID 103 R ++P P + L L FW+ G K H + +KYG I+R KLG+ +SV++ Sbjct: 21 RNVTDLPGPTNWPLLGSLLEIFWK-GGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGS 79 Query: 104 PEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEA 163 P + L+++E +P+R I PW AY + G+++ + W++ R A +++M P Sbjct: 80 PSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVE 139 Query: 164 TKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLE 223 ++ V DF+ + + G D+ +L +++FESI V++ +R G+L+ Sbjct: 140 IMKLDKKINEVLADFLERMDELCDERGR---IPDLYSELNKWSFESICLVLYEKRFGLLQ 196 Query: 224 EVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQN 283 + EA FI AI M T M+ P +L + TK W+ H AWD IF N Sbjct: 197 KETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDN 256 Query: 284 FYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMA 343 Q+ D+ +Y+ +S +++ A VTE+ V+TT+ +L W LY ++ Sbjct: 257 RLQRYSQQPGA--DFLCDIYQ---QDHLSKKELYAAVTELQLAAVETTANSLMWILYNLS 311 Query: 344 RNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLV 403 RN + Q L EV + Q A L+ +P LKA +KE++RL P R L V Sbjct: 312 RNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTV 371 Query: 404 LRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCL 463 L +Y +P T++ + LG F D F P RWL K+K I F +L FG G R C+ Sbjct: 372 LGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCI 431 Query: 464 GRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWP 513 GRR+AEL++ + L +++ + + V IL+P + + F P Sbjct: 432 GRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRP 481 >5VEU-A nrPDB Length = 480 Score = 102 bits (254), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 106/455 (23%), Positives = 189/455 (41%), Gaps = 54/455 (11%) Query: 79 VQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQR--- 135 + ++KYG ++ G + + + DP+ + + E Y + R Sbjct: 41 TECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE-------------CYSVFTNRRSL 87 Query: 136 -PIGVL-----LKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKA 189 P+G + L + WK+ R +++P T L + + + VL R +++ Sbjct: 88 GPVGFMKSAISLAEDEEWKRIR-----SLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRRE 142 Query: 190 GSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLN 249 + D ++ + IT FG ++ + NP+ F+++ + Sbjct: 143 AEKGKPVTLKDIFGAYSMDVITGTSFGVN---IDSLNNPQ-DPFVESTKKFLKFGF---- 194 Query: 250 LPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWEL--RQKGSVHHD---YRGILYR 304 L P + A +V D T NF + R K S +D +R + Sbjct: 195 LDPLFLSIILFPFLTPVFEALNVSLFPKD--TINFLSKSVNRMKKSRLNDKQKHRLDFLQ 252 Query: 305 LLGDSKMSFE----------DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRA 354 L+ DS+ S E ++ A + G +TTS L + LYE+A + VQ L+ Sbjct: 253 LMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQK 312 Query: 355 EVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTL 414 E+ A + + L + ETLRL P+++ L+R D+ + IP ++ Sbjct: 313 EIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSM 372 Query: 415 VQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTI 474 V + YAL +P ++ +PE F P R+ K +I + FG G R C+G R A + M + Sbjct: 373 VVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKL 432 Query: 475 FLINMLENFRVEIQHLSDVGTTFNL--ILMPEKPI 507 LI +L+NF + + + + +L PEKPI Sbjct: 433 ALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPI 467 >6DA2-A nrPDB Length = 487 Score = 101 bits (252), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 65/186 (34%), Positives = 102/186 (54%), Gaps = 5/186 (2%) Query: 326 GGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR-HQAQGDMATMLQLVPLLKASIKET 384 G +TTS L + +YE+A + VQ L+ E+ A ++A T+LQ+ L + ET Sbjct: 285 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQM-EYLDMVVNET 343 Query: 385 LRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKD 444 LRL PI++ L+R D+ + IP +V + YAL R+P ++ +PE F P R+ K+ Sbjct: 344 LRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKN 403 Query: 445 K-NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNL--IL 501 K NI + FG G R C+G R A + M + LI +L+NF + + + +L +L Sbjct: 404 KDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLL 463 Query: 502 MPEKPI 507 PEKP+ Sbjct: 464 QPEKPV 469 >6B82-A nrPDB Length = 509 Score = 92.4 bits (228), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 114/209 (54%), Gaps = 15/209 (7%) Query: 308 DSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARN----LKVQDMLRAEVLAARHQA 363 D ++ + + V E+ GV+TT+ TL+W + + N K+Q+ L +++ RH Sbjct: 279 DVGLTEDHVLMTVGEIFGAGVETTTTTLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQ 338 Query: 364 QGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL-VNDLVLRDYMIPAKTLVQVAIYAL 422 D + P L+A+I E +R+ P+S L ++ + D + +Y + T V + +++L Sbjct: 339 LSDRGNL----PYLEATICEVMRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINMWSL 394 Query: 423 GREPTFFFDPENFDPTRWLSKDKNITYFRN---LGFGWGVRQCLGRRIAELEMTIFLINM 479 + + +PE FDP R+L+++ + + L FG GVR CLG +A++E+ +FL + Sbjct: 395 HHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWI 454 Query: 480 LENFRVEI---QHLSDVGTTFNLILMPEK 505 L+ F +E+ Q L D+ F ++L P+K Sbjct: 455 LQRFTLEMPTGQPLPDLQGKFGVVLQPKK 483 >5YLW-A nrPDB Length = 495 Score = 91.3 bits (225), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 93/415 (22%), Positives = 176/415 (42%), Gaps = 27/415 (6%) Query: 83 QKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLK 142 ++YGP+ LG++ +V V PE + G I V + + +G L Sbjct: 57 KRYGPLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDKISMG-FLP 115 Query: 143 KSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDL 202 ++ W+ R +++ + ++ + + R + L ++K + DI + Sbjct: 116 VASEWRDMRKICKEQMFSNQSMEAS----QGLRRQKLQQLLDHVQKCSDSGRAVDIREAA 171 Query: 203 FRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKT 262 F ++ +F + + E + I+ + + VP D F + R Sbjct: 172 FITTLNLMSATLFSSQATEFDSKATMEFKEIIEGVATI--VGVPNFA---DYFPILRPFD 226 Query: 263 WKDHVAAWDVIFSKADIYTQNFYWELRQKGSVH------HDYRGILYRLL--GDSKMSFE 314 + DV F K + + E + + D+ I+ ++ + K+ Sbjct: 227 PQGVKRRADVFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQANEFKLKTH 286 Query: 315 DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLA-ARHQAQGDMATMLQL 373 + ++ GG DT + +++W + E+ N L+AE+ + A + D + M +L Sbjct: 287 HFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDESAMPKL 346 Query: 374 VPLLKASIKETLRLHPIS-VTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDP 432 P L+A IKE +R+HP + L R +D + Y+IP T + + YA+GR+P+ + DP Sbjct: 347 -PYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSIWTDP 405 Query: 433 ENFDPTRWLSKDKNITY----FRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 E FDP R+L D I + + L FG G R C G +A + + ++ NF Sbjct: 406 ETFDPERFL--DNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNF 458 >4R1Z-A nrPDB Length = 439 Score = 91.3 bits (225), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 60/209 (28%), Positives = 114/209 (54%), Gaps = 15/209 (7%) Query: 308 DSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARN----LKVQDMLRAEVLAARHQA 363 D ++ + + V ++ GV+TT+ L+W + + N K+Q+ L +++ RH Sbjct: 215 DVGLTEDHVLMTVGDIFGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQ 274 Query: 364 QGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL-VNDLVLRDYMIPAKTLVQVAIYAL 422 D + P L+A+I+E LR+ P+S L ++ + D + +Y + T V + +++L Sbjct: 275 LSDRGNL----PYLEATIREVLRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSL 330 Query: 423 GREPTFFFDPENFDPTRWLSKDKNITYFRN---LGFGWGVRQCLGRRIAELEMTIFLINM 479 + + +PE FDP R+L+++ + + L FG GVR CLG +A++E+ +FL + Sbjct: 331 HHDKKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWI 390 Query: 480 LENFRVEI---QHLSDVGTTFNLILMPEK 505 L+ F +E+ Q L D+ F ++L P+K Sbjct: 391 LQRFTLEMPTGQPLPDLQGKFGVVLQPKK 419 >4R20-A nrPDB Length = 486 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 55/204 (26%), Positives = 99/204 (48%), Gaps = 5/204 (2%) Query: 307 GDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGD 366 G ++ + + E GV+TTS TL W + + + ++Q+ ++AE+ + Sbjct: 268 GADDITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPP 327 Query: 367 MATMLQLVPLLKASIKETLRLHPIS-VTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGRE 425 + +PLL A + E +R+ P+S + + + D L + +P T V V ++A+ + Sbjct: 328 CLSDRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHD 387 Query: 426 PTFFFDPENFDPTRWLS-KDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFR 484 P + PE F+P R+L K T L FG G R C+G +A +E+ +F+ L+ F Sbjct: 388 PKHWDQPEQFNPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFS 447 Query: 485 VEI---QHLSDVGTTFNLILMPEK 505 L D+ F ++L PE+ Sbjct: 448 FSCPSEASLPDLQGRFGVVLQPER 471 >6C94-A nrPDB Length = 497 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 97/402 (24%), Positives = 163/402 (40%), Gaps = 34/402 (8%) Query: 138 GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGD 197 G+L+ W + R +++ P + L A+ D ++ + +K S D Sbjct: 103 GLLVLDGPKWFQHR-----KLLTPGFHYDVLKPYVAIFADSTRIMLEKWEKKACEGKSFD 157 Query: 198 ISDDLFRFAFESITNVIFGERQGMLEE------VVNPE----AQRFIDAIYQMFHTSVPM 247 I D+ A +++ FG+ L V E Q+ ID+ +H + Sbjct: 158 IFSDVGHMALDTLMKCTFGKGDSGLNHRDSSYYVAVSELTLLMQQRIDSF--QYHNDF-I 214 Query: 248 LNLPPDLFRLFR-TKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLL 306 L P R R + DH D + + Q+ + + H D+ IL + Sbjct: 215 YWLTPHGRRFLRACRAAHDHT---DRVIRQRKAALQDEKEREKIQNRRHLDFLDILLDVR 271 Query: 307 GDS--KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQ 364 G+S ++S D++A V + G DTT+ + W LY MA + Q R EV + Sbjct: 272 GESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQRCREEV----REIL 327 Query: 365 GDMATM----LQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD-YMIPAKTLVQVAI 419 GD + L + L +KE RL+P + R L + D +PA +L+ + I Sbjct: 328 GDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKPVSFVDGRSLPAGSLISLHI 387 Query: 420 YALGREPTFFFDPENFDPTRWLSKDKNITY-FRNLGFGWGVRQCLGRRIAELEMTIFLIN 478 YAL R + DPE FDP R+ ++ + + + + F G R C+G++ A EM + Sbjct: 388 YALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAGPRNCIGQQFAMNEMKVVTAL 447 Query: 479 MLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQ 520 L F + L L+L + I P +A + Sbjct: 448 CLLRFEFSVDPLRLPIKLPQLVLRSKNGIHLYLKPLGPKAEK 489 >6IQ5-A nrPDB Length = 463 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 56/210 (26%), Positives = 103/210 (49%), Gaps = 16/210 (7%) Query: 307 GDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAE----VLAARHQ 362 G +++ E++ A +T++ DT S LQW L R VQ ++AE V R Sbjct: 244 GGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLP 303 Query: 363 AQGDMATMLQLVPLLKASIKETLRLHP-ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYA 421 GD + P + A + E +R + VT+ + + Y IP T+V V ++ Sbjct: 304 CMGDQPNL----PYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWS 359 Query: 422 LGREPTFFFDPENFDPTRWLSKD----KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLI 477 + +P + +PENFDP R+L KD K++T R + F G R+C+G ++++++ +F+ Sbjct: 360 VNHDPVKWPNPENFDPARFLDKDGLINKDLTS-RVMIFSVGKRRCIGEELSKMQLFLFIS 418 Query: 478 NMLE--NFRVEIQHLSDVGTTFNLILMPEK 505 + +FR + + ++ L + P+ Sbjct: 419 ILAHQCDFRANPNEPAKMNFSYGLTIKPKS 448 >2VE3-A nrPDB Length = 444 Score = 78.6 bits (192), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 101/450 (22%), Positives = 179/450 (39%), Gaps = 51/450 (11%) Query: 44 SPRPFNEIP-SPGDNG--WLN-LYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESV 99 SP N +P PGD G WL +F + K + Q++GPI++ +L + Sbjct: 4 SPTNLNSLPIPPGDFGLPWLGETLNFLNDGDFGK------KRQQQFGPIFKTRLFGKNVI 57 Query: 100 YVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVM 159 ++ LF E + W + P + + + R L Q + Sbjct: 58 FISGALANRFLFTKE----QETFQATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFL 113 Query: 160 APEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQ 219 P ++LP +D + + + +++ G N L R F+ + GE+ Sbjct: 114 -PRTLDSYLPKMDGIVQGY-------LEQWGKAN-EVIWYPQLRRMTFDVAATLFMGEKV 164 Query: 220 GMLEEVVNPEAQRFIDAIYQ-MFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD 278 NP+ + + Q +F +P+ N T K A ++ Sbjct: 165 SQ-----NPQLFPWFETYIQGLFSLPIPLPN----------TLFGKSQRARALLLAELEK 209 Query: 279 IYTQNFYWELRQKGSVHHDYRGILYRLLGDSK--MSFEDIKANVTEMLAGGVDTTSMTLQ 336 I +Q+ D GIL D+ +S ++K + +L G +T + L Sbjct: 210 IIKAR-----QQQPPSEEDALGILLAARDDNNQPLSLPELKDQILLLLFAGHETLTSALS 264 Query: 337 WHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQR 396 + ++ +++ +R E +Q A L+ +P L ++E LRL P R Sbjct: 265 SFCLLLGQHSDIRERVRQEQ-NKLQLSQELTAETLKKMPYLDQVLQEVLRLIPPVGGGFR 323 Query: 397 YLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITY---FRNL 453 L+ D + + P LV I +P + DPE FDP R+ + D + T+ F ++ Sbjct: 324 ELIQDCQFQGFHFPKGWLVSYQISQTHADPDLYPDPEKFDPERF-TPDGSATHNPPFAHV 382 Query: 454 GFGWGVRQCLGRRIAELEMTIFLINMLENF 483 FG G+R+CLG+ A LEM +F +++ F Sbjct: 383 PFGGGLRECLGKEFARLEMKLFATRLIQQF 412 >5FSA-A nrPDB Length = 490 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 56/225 (24%), Positives = 106/225 (47%), Gaps = 28/225 (12%) Query: 310 KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMAT 369 KM+ ++I + +L GG T++ T W L + +QD++ EV+ + GD+ Sbjct: 249 KMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLND 308 Query: 370 M----LQLVPLLKASIKETLRLHPISVTLQRYLVNDLVL--RDYMIPAKTLVQVAIYALG 423 + LQ +P + +IKETLR+H ++ R + N L + +Y++P V V+ Sbjct: 309 LTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAH 368 Query: 424 REPTFFFDPENFDPTRW---LSKDKNITYFRN------------------LGFGWGVRQC 462 +F +PE+FDPTRW +K ++++ + L FG G +C Sbjct: 369 TSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRC 428 Query: 463 LGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTF-NLILMPEKP 506 +G + A +++ L + N R I + +++++P +P Sbjct: 429 IGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEP 473 >3QZ1-A nrPDB Length = 496 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 96/434 (22%), Positives = 173/434 (39%), Gaps = 58/434 (13%) Query: 76 LHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQR 135 +H + QK GP+YR +LG E V + + E +I WV + Q Sbjct: 47 IHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTI-----------EEAMIRKWVDFAGRPQI 95 Query: 136 PIGVLLKK----------SAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRR 185 P L+ + S WK + L + + + P +D ++++F R Sbjct: 96 PSYKLVSQRCQDISLGDYSLLWKAHK-KLTRSALLLGTRSSMEPWVDQLTQEFCE---RM 151 Query: 186 IKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSV 245 +AG+ I + I + FG ++ L + Q D + H S+ Sbjct: 152 RVQAGA---PVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQ---DLMKTWDHWSI 205 Query: 246 PMLNL--------PPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHD 297 +L++ P L+RL + +DH+ + K + + + + Sbjct: 206 QILDMVPFLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQW------RDMTDYM 259 Query: 298 YRGILYRLL--GDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAE 355 +G+ + + G ++ + +V ++ GG +TT+ TL W + + + ++Q L+ E Sbjct: 260 LQGVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEE 319 Query: 356 VLAARHQAQGDMATMLQL-----VPLLKASIKETLRLHPI-SVTLQRYLVNDLVLRDYMI 409 + R G + + +PLL A+I E LRL P+ + L + Y I Sbjct: 320 L--DRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDI 377 Query: 410 PAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAE 469 P +V + + T + P F P R+L N + L FG G R CLG +A Sbjct: 378 PEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANPS---ALAFGCGARVCLGESLAR 434 Query: 470 LEMTIFLINMLENF 483 LE+ + L +L+ F Sbjct: 435 LELFVVLARLLQAF 448 >2PG7-A nrPDB Length = 476 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 48/187 (25%), Positives = 96/187 (51%), Gaps = 14/187 (7%) Query: 308 DSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAE---VLAARHQAQ 364 +++ +++ ++ GG +T S TL++ + ++ +V+ + E V+ Q + Sbjct: 261 NTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPK 320 Query: 365 -GDMATMLQLVPLLKASIKETLRLHP-ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYAL 422 D A M P ++A I E R I ++L R + D RD+ +P T V + ++ Sbjct: 321 FEDRAKM----PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSV 376 Query: 423 GREPTFFFDPENFDPTRWLSKD---KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINM 479 R+P+FF +P++F+P +L++ K F + F G R C G +A +E+ +F + Sbjct: 377 LRDPSFFSNPQDFNPQHFLNEKGQFKKSDAF--VPFSIGKRNCFGEGLARMELFLFFTTV 434 Query: 480 LENFRVE 486 ++NFR++ Sbjct: 435 MQNFRLK 441 >3DL9-A nrPDB Length = 479 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 95/207 (45%), Gaps = 16/207 (7%) Query: 308 DSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV---LAARHQAQ 364 S S E++ +V E++ G +TT+ L+W + MA +Q ++ E+ + + Sbjct: 266 SSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS 325 Query: 365 GDMATMLQLVPLLKASIKETLRL-HPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALG 423 D + P +A + E LR + + + + D V+R Y IP T V +Y++ Sbjct: 326 WDDKCKM---PYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVH 382 Query: 424 REPTFFFDPENFDPTRWLSKDKNITYFRN----LGFGWGVRQCLGRRIAELEMTIFLINM 479 + ++ DPE F P R+L YF + F G R CLG +A +EM +F + Sbjct: 383 FDEKYWRDPEVFHPERFLDSS---GYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTAL 439 Query: 480 LENFRVEIQH--LSDVGTTFNLILMPE 504 L+ F + H + D+ + L P+ Sbjct: 440 LQRFHLHFPHELVPDLKPRLGMTLQPQ 466 >5VBU-A nrPDB Length = 476 Score = 71.6 bits (174), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 98/438 (22%), Positives = 180/438 (41%), Gaps = 78/438 (17%) Query: 83 QKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAY--------HQYYQ 134 QK+GPIYR LG ++ V V++ + E ++ W + ++ Sbjct: 35 QKFGPIYRLHLG-LQDVVVLNSKRTI----------EEAMVKKWADFAGRPEPLTYKLVS 83 Query: 135 R--PIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSG 192 R P L S WK + L + + + P+++ ++++F + +A G Sbjct: 84 RNYPDLSLGDYSLLWKAHK-KLTRSALLLGIRDSMEPVVEQLTQEFCERM-----RAQPG 137 Query: 193 NYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMF-HTSVPMLNL- 250 I ++ I + FG++ + ++ + P + I + + + H S+ ++++ Sbjct: 138 TPVA-IEEEFSLLTCSIICYLTFGDK--IKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVI 194 Query: 251 -------PPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGIL- 302 P L RL + +DH+ + K + V +R ++ Sbjct: 195 PFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESL--------------VAGQWRDMMD 240 Query: 303 YRLLGDSKMSFEDIKANVTE---------MLAGGVDTTSMTLQWHLYEMARNLKVQDMLR 353 Y L G ++ S E+ + E +L GG +TT+ TL W + + + ++Q L+ Sbjct: 241 YMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQ 300 Query: 354 AEV-------LAARHQAQGDMATMLQLVPLLKASIKETLRLHPI-SVTLQRYLVNDLVLR 405 E+ ++ D A + PLL A+I E LRL P+ + L + Sbjct: 301 EELDHELGPGASSSRVPYKDRARL----PLLNATIAEVLRLRPVVPLALPHRTTRPSSIS 356 Query: 406 DYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGR 465 Y IP T++ + + T + P F P R+L KN R L FG G R CLG Sbjct: 357 GYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKN---SRALAFGCGARVCLGE 413 Query: 466 RIAELEMTIFLINMLENF 483 +A LE+ + L +L+ F Sbjct: 414 PLARLELFVVLTRLLQAF 431 >5W0C-A nrPDB Length = 477 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 48/186 (25%), Positives = 93/186 (50%), Gaps = 14/186 (7%) Query: 309 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARN----LKVQDMLRAEVLAARHQAQ 364 S+ + E ++ ++ G +TTS TL++ L + ++ KVQ+ + + R Sbjct: 263 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 322 Query: 365 GDMATMLQLVPLLKASIKETLR-LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALG 423 D + M P A + E R + + +L + D+ R+Y+IP T + +++ ++ Sbjct: 323 QDRSHM----PYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVL 378 Query: 424 REPTFFFDPENFDPTRWLSKDKNI---TYFRNLGFGWGVRQCLGRRIAELEMTIFLINML 480 + F +PE FDP +L + N YF + F G R C+G +A +E+ +FL ++L Sbjct: 379 HDNKEFPNPEMFDPHHFLDEGGNFKKSKYF--MPFSAGKRICVGEALAGMELFLFLTSIL 436 Query: 481 ENFRVE 486 +NF ++ Sbjct: 437 QNFNLK 442 >2NNH-A nrPDB Length = 476 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 52/207 (25%), Positives = 102/207 (49%), Gaps = 18/207 (8%) Query: 309 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV--LAARHQAQG- 365 S+ + E++ V ++ G +TTS TL++ L + ++ +V ++ E+ + RH++ Sbjct: 262 SEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCM 321 Query: 366 -DMATMLQLVPLLKASIKETLRLHPISVT-LQRYLVNDLVLRDYMIPAKTLVQVAIYALG 423 D + M P A + E R + T + + D R+Y+IP T + + ++ Sbjct: 322 QDRSHM----PYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVL 377 Query: 424 REPTFFFDPENFDPTRWLSKDKNIT---YFRNLGFGWGVRQCLGRRIAELEMTIFLINML 480 + F +P FDP +L K+ N YF + F G R C G +A +E+ +FL +L Sbjct: 378 HDDKEFPNPNIFDPGHFLDKNGNFKKSDYF--MPFSAGKRICAGEGLARMELFLFLTTIL 435 Query: 481 ENFRV----EIQHLSDVGTTFNLILMP 503 +NF + ++++L+ T ++ +P Sbjct: 436 QNFNLKSVDDLKNLNTTAVTKGIVSLP 462 >4GQS-A nrPDB Length = 477 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 51/186 (27%), Positives = 91/186 (48%), Gaps = 14/186 (7%) Query: 309 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARN----LKVQDMLRAEVLAARHQAQ 364 S+ + E++ ++L G +TTS TL++ L + ++ KVQ+ + V R Sbjct: 263 SEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCM 322 Query: 365 GDMATMLQLVPLLKASIKETLR-LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALG 423 D M P A + E R + I +L + D+ R+Y+IP T + ++ ++ Sbjct: 323 QDRGHM----PYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVL 378 Query: 424 REPTFFFDPENFDPTRWLSKDKNI---TYFRNLGFGWGVRQCLGRRIAELEMTIFLINML 480 + F +PE FDP +L + N YF + F G R C+G +A +E+ +FL +L Sbjct: 379 HDNKEFPNPEMFDPRHFLDEGGNFKKSNYF--MPFSAGKRICVGEGLARMELFLFLTFIL 436 Query: 481 ENFRVE 486 +NF ++ Sbjct: 437 QNFNLK 442 >4H1N-A nrPDB Length = 479 Score = 68.6 bits (166), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 55/185 (29%), Positives = 82/185 (44%), Gaps = 14/185 (7%) Query: 309 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMAR----NLKVQDMLRAEVLAARHQAQ 364 S+ +++ V + A G +TTS TL++ M + +VQ + + + R A Sbjct: 262 SEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLKYPHVTERVQKEIEQVIGSHRPPAL 321 Query: 365 GDMATMLQLVPLLKASIKETLRLHP-ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALG 423 D A M P A I E RL I + + D R Y+IP T V + + Sbjct: 322 DDRAKM----PYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRGYVIPKNTEVFPVLSSAL 377 Query: 424 REPTFFFDPENFDPTRWLSKDKNITYFRNLGF---GWGVRQCLGRRIAELEMTIFLINML 480 +P +F P F+P +L D N RN GF G R CLG IA E+ +F +L Sbjct: 378 HDPRYFETPNTFNPGHFL--DANGALKRNEGFMPFSLGKRICLGEGIARTELFLFFTTIL 435 Query: 481 ENFRV 485 +NF + Sbjct: 436 QNFSI 440 >1N6B-A nrPDB Length = 473 Score = 68.2 bits (165), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 48/185 (25%), Positives = 95/185 (51%), Gaps = 14/185 (7%) Query: 310 KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV--LAARHQAQG-- 365 + + E + V+++ G +TTS TL++ L + ++ +V ++ E+ + RH++ Sbjct: 260 EFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPEVAARVQEEIERVIGRHRSPCMQ 319 Query: 366 DMATMLQLVPLLKASIKETLR-LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGR 424 D + M P A I E R + + L + D+ R+Y IP T + ++ ++ Sbjct: 320 DRSRM----PYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRNYFIPKGTDIITSLTSVLH 375 Query: 425 EPTFFFDPENFDPTRWLSKDKNIT---YFRNLGFGWGVRQCLGRRIAELEMTIFLINMLE 481 + F +P+ FDP +L + N YF + F G R C+G +A +E+ +FL ++L+ Sbjct: 376 DEKAFPNPKVFDPGHFLDESGNFKKSDYF--MPFSAGKRMCVGEGLARMELFLFLTSILQ 433 Query: 482 NFRVE 486 NF+++ Sbjct: 434 NFKLQ 438 >3EL3-A nrPDB Length = 467 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 52/194 (26%), Positives = 84/194 (43%), Gaps = 8/194 (4%) Query: 314 EDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQL 373 ++I V +L G +T + T+ W L +A + + D +R EV A G + Sbjct: 262 QEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAV----TGGRPVAFED 317 Query: 374 VPLLKAS---IKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFF 430 V L+ + I E +RL P L R V + L Y IPA + + YA+ R+P + Sbjct: 318 VRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYD 377 Query: 431 DPENFDPTRWL-SKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQH 489 D FDP RWL + N+ + F G R+C + ++T+ + +R E Sbjct: 378 DNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVA 437 Query: 490 LSDVGTTFNLILMP 503 S+ + L P Sbjct: 438 GSNDAVRVGITLRP 451 >3MDV-A nrPDB Length = 456 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 96/443 (21%), Positives = 175/443 (39%), Gaps = 35/443 (7%) Query: 83 QKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYY-QRPIGVLL 141 +KYGP+ R + + SV V PE V S N + + + A + +R G L Sbjct: 21 KKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKM---YRALQTVFGERLFGQGL 77 Query: 142 KKSA---AWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDI 198 W K R ++ + + + + + + V +L + G + Sbjct: 78 VSECNYERWHKQRRVIDL-AFSRSSLVSLMETFNEKAEQLVEILEAK----ADGQTPVSM 132 Query: 199 SDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLF 258 D L A + + FG ML P +Q A+ M N F Sbjct: 133 QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQ----AVKLMLEGITASRNTLAK-FLPG 187 Query: 259 RTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFED--I 316 + K ++ + + + Q L++ V D IL ++L + + +D + Sbjct: 188 KRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPAD---ILTQILKAEEGAQDDEGL 244 Query: 317 KANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV----LAARHQAQGDMATMLQ 372 N G +T++ L + + E++R ++ L+AEV + R+ D+ + Sbjct: 245 LDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQY 304 Query: 373 LVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDP 432 L +LK E+LRL+P + R L + ++ +P T + + Y +GR T+F DP Sbjct: 305 LSQVLK----ESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDP 360 Query: 433 ENFDPTRW--LSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHL 490 F+P R+ + TYF F G R C+G++ A++E+ + + +L+ + Sbjct: 361 LTFNPDRFGPGAPKPRFTYF---PFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPG 417 Query: 491 SDVGTTFNLILMPEKPISFTFWP 513 G L P P+ T P Sbjct: 418 QRFGLQEQATLKPLDPVLCTLRP 440 >2X2N-A nrPDB Length = 475 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 69/334 (20%), Positives = 145/334 (43%), Gaps = 26/334 (7%) Query: 166 NFLP--LLDAVSRDFVSVLHRRIKKAGSGNYSGD-----ISDDLFRFAFESITNVIFGE- 217 NFL L A ++FV + ++K + N+ D + +D + +FGE Sbjct: 114 NFLAEELTIAKFQNFVPAIQHEVRKFMAANWDKDEGEINLLEDCSTMIINTACQCLFGED 173 Query: 218 -RQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSK 276 R+ + +A+RF + +M + +P P L +L ++ + H A ++ Sbjct: 174 LRKRL-------DARRFAQLLAKMESSLIPAAVFLPILLKLPLPQSARCHEARTELQKIL 226 Query: 277 ADIYTQNFYWELRQKGSVHHDYRGILYRLLGD-SKMSFEDIKANVTEMLAGGVDTTSMTL 335 ++I + + S G+L + D + MS ++ + + G T+S+T Sbjct: 227 SEIIIARKAAAVNKDSSTSDLLSGLLSAVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITT 286 Query: 336 QWHLYEMAR--NLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVT 393 W + + N+K + LR E+ AQ + ++ +P + +E++R P + Sbjct: 287 TWSMLHLMHPANVKHLEALRKEI--EEFPAQLNYNNVMDEMPFAERCARESIRRDPPLLM 344 Query: 394 LQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNL 453 L R ++ D+ + Y++P ++ + + F +P +DP R +K F + Sbjct: 345 LMRKVMADVKVGSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPER---DEKVEGAF--I 399 Query: 454 GFGWGVRQCLGRRIAELEMTIFLINMLENFRVEI 487 GFG GV +C+G++ L++ L ++ ++ Sbjct: 400 GFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQL 433 >2HI4-A nrPDB Length = 495 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 54/228 (23%), Positives = 94/228 (41%), Gaps = 20/228 (8%) Query: 280 YTQNFYWELRQKGSVHH------DYRGILYRLLGDSK---------MSFEDIKANVTEML 324 + Q F W L++ H+ R I L SK + E I V ++ Sbjct: 232 FNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIF 291 Query: 325 AGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKET 384 G DT + + W L + ++Q ++ E+ + + + +P L+A I ET Sbjct: 292 GAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILET 351 Query: 385 LRLHP-ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSK 443 R + T+ D L + IP K V V + + +P + DP F P R+L+ Sbjct: 352 FRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTA 411 Query: 444 DKNIT----YFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEI 487 D + + FG G R+C+G +A+ E+ +FL +L+ + Sbjct: 412 DGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSV 459 >6DWN-A nrPDB Length = 491 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 48/184 (26%), Positives = 86/184 (46%), Gaps = 6/184 (3%) Query: 307 GDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGD 366 + ++S E I V ++ G DT + + W L + N +VQ ++ E+ +++ Sbjct: 271 ANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRP 330 Query: 367 MATMLQLVPLLKASIKETLRLHP-ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGRE 425 + +P ++A I ET R + T+ D L+ + IP V V + + + Sbjct: 331 RLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHD 390 Query: 426 PTFFFDPENFDPTRWLSKDKNITYF---RNLGFGWGVRQCLGRRIAELEMTIFLINMLEN 482 + +P F P R+L+ D I + + FG G R+C+G IA E+ +FL +L+ Sbjct: 391 QKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ- 449 Query: 483 FRVE 486 RVE Sbjct: 450 -RVE 452 >2WX2-A nrPDB Length = 473 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 72/356 (20%), Positives = 147/356 (41%), Gaps = 31/356 (8%) Query: 166 NFLP--LLDAVSRDFVSVLHRRIKKAGSGNYSGD-----ISDDLFRFAFESITNVIFGER 218 NFL L A ++FV + ++K + N+ D + +D + +FGE Sbjct: 114 NFLAEELTIAKFQNFVPAIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGED 173 Query: 219 QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD 278 L + +N A+ F + +M + +P P L RL ++ + A ++ + Sbjct: 174 ---LRKRLN--ARHFAQLLSKMESSLIPAAVFMPWLLRLPLPQSARCREARAELQKILGE 228 Query: 279 IYTQNFYWELRQKGSVHHDYRGILYRLLGD-SKMSFEDIKANVTEMLAGGVDTTSMTLQW 337 I E + + G+L + D ++MS ++ + + G T+++T W Sbjct: 229 IIVAREKEEASKDNNTSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSW 288 Query: 338 HLYEM--ARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQ 395 + + +N K D L E+ AQ + ++ +P + ++E++R P + + Sbjct: 289 SMLHLMHPKNKKWLDKLHKEI--DEFPAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVM 346 Query: 396 RYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGF 455 R + ++ + Y++P ++ + + F +P +DP R D +GF Sbjct: 347 RMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGAF-----IGF 401 Query: 456 GWGVRQCLGRRIAELEMTIFLINMLENFRVEI---------QHLSDVGTTFNLILM 502 G GV +C+G++ A L++ L + ++ H VG T N L+ Sbjct: 402 GAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLV 457 >3L4D-A nrPDB Length = 453 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 68/342 (19%), Positives = 144/342 (42%), Gaps = 41/342 (11%) Query: 166 NFLP--LLDAVSRDFVSVLHRRIKKAGSGNYSGD-----ISDDLFRFAFESITNVIFGE- 217 NFL L A ++F + ++K N++ D I DD + +FGE Sbjct: 100 NFLAEELTVAKFQNFAPSIQHEVRKFMKANWNKDEGEINILDDCSAMIINTACQCLFGED 159 Query: 218 -RQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSK 276 R+ + +A++F + +M +P P + +L ++++ A ++ Sbjct: 160 LRKRL-------DARQFAQLLAKMESCLIPAAVFLPWILKLPLPQSYRCRDARAEL---- 208 Query: 277 ADIYTQNFYWELRQKGSVHHDYRGILYRLLG-----DSKMSFEDIKANVTEMLAGGVDTT 331 DI ++ +++ + +L LLG ++MS ++ + + G T+ Sbjct: 209 QDILSEIIIAREKEEAQKDTNTSDLLAGLLGAVYRDGTRMSQHEVCGMIVAAMFAGQHTS 268 Query: 332 SMTLQWHLYEMARNLKVQDMLRAEVLAARHQ------AQGDMATMLQLVPLLKASIKETL 385 ++T W L L + D LA HQ AQ + +++ +P + +E++ Sbjct: 269 TITTTWSL------LHLMDPRNKRHLAKLHQEIDEFPAQLNYDNVMEEMPFAEQCARESI 322 Query: 386 RLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDK 445 R P V L R ++ + + Y++P ++ + ++ F +P ++P R + Sbjct: 323 RRDPPLVMLMRKVLKPVQVGKYVVPEGDIIACSPLLSHQDEEAFPNPREWNPER----NM 378 Query: 446 NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEI 487 + GFG GV +C+G + L++ L +L ++ E+ Sbjct: 379 KLVDGAFCGFGAGVHKCIGEKFGLLQVKTVLATVLRDYDFEL 420 >3E6I-A nrPDB Length = 476 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 44/179 (24%), Positives = 86/179 (48%), Gaps = 6/179 (3%) Query: 312 SFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATML 371 + + I V ++ G +TTS TL++ L + + ++++ L E+ ++ Sbjct: 264 TMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDR 323 Query: 372 QLVPLLKASIKETLR-LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFF 430 Q +P + A + E R + + L D + R Y+IP T+V + ++ + F Sbjct: 324 QEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFP 383 Query: 431 DPENFDPTRWLSKD---KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVE 486 DPE F P +L+++ K YF+ F G R C G +A +E+ + L +L++F ++ Sbjct: 384 DPEKFKPEHFLNENGKFKYSDYFK--PFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 440 >5UYS-A nrPDB Length = 494 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 46/184 (25%), Positives = 91/184 (49%), Gaps = 10/184 (5%) Query: 311 MSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATM 370 +S I + ++ GV+TT+ ++W L + N +V+ L E+ ++ + Sbjct: 269 LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD 328 Query: 371 LQLVPLLKASIKETLRLHPISVTLQRYLVN-DLVLRDYMIPAKTLVQVAIYALGREPTFF 429 + LL+A+I+E LRL P++ L + N D + ++ + T V + ++AL + Sbjct: 329 RNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW 388 Query: 430 FDPENFDPTRWLSK------DKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 P+ F P R+L+ +++Y L FG G R C+G +A E+ + + +L+ F Sbjct: 389 HQPDQFMPERFLNPAGTQLISPSVSY---LPFGAGPRSCIGEILARQELFLIMAWLLQRF 445 Query: 484 RVEI 487 +E+ Sbjct: 446 DLEV 449 >2W0A-A nrPDB Length = 455 Score = 62.0 bits (149), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 48/187 (25%), Positives = 84/187 (44%), Gaps = 10/187 (5%) Query: 307 GDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGD 366 G + S ++I M+ G T+S T W L E+ R+ A V+ + GD Sbjct: 237 GTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAY----AAVIDELDELYGD 292 Query: 367 MATM----LQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYAL 422 ++ L+ +P L+ +KETLRLHP + L R + ++ + I LV + Sbjct: 293 GRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAIS 352 Query: 423 GREPTFFFDPENFDPTRWLS--KDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML 480 R P F DP +F P R+ ++ + + + FG G +C+G A +++ +L Sbjct: 353 NRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLL 412 Query: 481 ENFRVEI 487 + E+ Sbjct: 413 REYEFEM 419 >3R9C-A nrPDB Length = 418 Score = 61.6 bits (148), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 35/106 (33%), Positives = 51/106 (48%), Gaps = 8/106 (7%) Query: 378 KASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDP 437 A I+ET+R P + RY +DL + + +P + + + A R+PT P+ FDP Sbjct: 290 SAVIEETMRYDPPVQLVSRYAGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDP 349 Query: 438 TRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 R R+LGFG G CLG +A LE T+ L + F Sbjct: 350 DR--------AQIRHLGFGKGAHFCLGAPLARLEATVALPALAARF 387 >6AYB-A nrPDB Length = 466 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 48/193 (24%), Positives = 88/193 (45%), Gaps = 9/193 (4%) Query: 324 LAGGVDTTSMTLQWHLYEMARNLKVQDMLRAE---VLAARHQAQGDMATMLQLVPLLKAS 380 L G T+S+T W L + N KV + +R E ++ + D + L+A Sbjct: 266 LFAGQHTSSITSSWTLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDY---LEAC 322 Query: 381 IKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRW 440 +KE LR++P + + R Y+IP ++ V+ GR + +P+ FDP R Sbjct: 323 MKEALRMYPPLIMIMRMARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERL 382 Query: 441 LSKDKNITY-FRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVE-IQHLSDVGTTFN 498 + ++ + + + FG G +C+G A L++ + +L F +E I + D T + Sbjct: 383 TERKEHEKFKYGAVPFGAGRHKCIGENFALLQVKSIISILLRYFDMEYIGKIPDPSYT-S 441 Query: 499 LILMPEKPISFTF 511 L++ P P + Sbjct: 442 LVVGPSPPTRMRY 454 >5JLC-A nrPDB Length = 515 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 67/255 (26%), Positives = 110/255 (43%), Gaps = 41/255 (16%) Query: 287 ELRQKGSVHHDYRGILYRLLGDS------KMSFEDIKANVTEMLAGGVDTTSMTLQWHLY 340 E R+K + + R ++ L+ +S KM+ ++I + +L GG T++ T W L Sbjct: 253 ERREKNDIQN--RDLIDELMKNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLL 310 Query: 341 EMARNLKVQDMLRAEVLAARHQAQGDMA-TMLQLVPLLKASIKETLRLHPISVTLQRYLV 399 +A VQ+ L E + + ++ LQ +PLL IKETLRLH +L R ++ Sbjct: 311 HLAERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLFRKVM 370 Query: 400 NDLVLRD--YMIPAKTLVQVAIYALGREPTFFFDPENFDPTRW----------------- 440 D+ + + Y++P V V+ + FF P F+ RW Sbjct: 371 RDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDY 430 Query: 441 ----LSKDKNITYFRNLGFGWGVRQCLGRRIAELE----MTIFLINMLENFRVEIQHL-- 490 +SK + Y L FG G +C+G A + M+IF+ M + E + + Sbjct: 431 GFGAISKGVSSPY---LPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTEGETVPP 487 Query: 491 SDVGTTFNLILMPEK 505 SD + L P K Sbjct: 488 SDFTSMVTLPTAPAK 502 >3TBG-A nrPDB Length = 479 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 50/191 (26%), Positives = 87/191 (45%), Gaps = 16/191 (8%) Query: 307 GDSKMSF--EDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAE----VLAAR 360 G+ + SF E+++ V ++ + G+ TTS TL W L M + VQ ++ E + R Sbjct: 262 GNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVR 321 Query: 361 HQAQGDMATMLQLVPLLKASIKETLR---LHPISVTLQRYLVNDLVLRDYMIPAKTLVQV 417 GD A M P A I E R + P+ VT D+ ++ + IP T + Sbjct: 322 RPEMGDQAHM----PYTTAVIHEVQRFGDIVPLGVT--HMTSRDIEVQGFRIPKGTTLIT 375 Query: 418 AIYALGREPTFFFDPENFDPTRWLSKDKNITYFRN-LGFGWGVRQCLGRRIAELEMTIFL 476 + ++ ++ + P F P +L + L F G R CLG +A +E+ +F Sbjct: 376 NLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFF 435 Query: 477 INMLENFRVEI 487 ++L++F + Sbjct: 436 TSLLQHFSFSV 446 >1CPT-A nrPDB Length = 428 Score = 58.5 bits (140), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 96/213 (45%), Gaps = 34/213 (15%) Query: 305 LLGDSKMS---FED--IKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAA 359 LL +SK+ +D I A + G DTTS + + ++RN E LA Sbjct: 241 LLANSKLDGNYIDDKYINAYYVAIATAGHDTTSSSSGGAIIGLSRN--------PEQLAL 292 Query: 360 RHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAI 419 A+ D A L+P L + E +R + R + D +R I + ++ Sbjct: 293 ---AKSDPA----LIPRL---VDEAVRWTAPVKSFMRTALADTEVRGQNIKRGDRIMLSY 342 Query: 420 YALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINM 479 + R+ F +P+ FD TR+ + R+LGFGWG CLG+ +A+LEM IF + Sbjct: 343 PSANRDEEVFSNPDEFDITRFPN--------RHLGFGWGAHMCLGQHLAKLEMKIFFEEL 394 Query: 480 LENFR-VEIQHLSDVGTTFNLILMPEK-PISFT 510 L + VE+ + T N + P+ PI FT Sbjct: 395 LPKLKSVELSGPPRLVAT-NFVGGPKNVPIRFT 426 >3S79-A nrPDB Length = 503 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 58/226 (25%), Positives = 104/226 (46%), Gaps = 19/226 (8%) Query: 301 ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAE---VL 357 IL GD ++ E++ + EML DT S++L + L+ +A++ V++ + E V+ Sbjct: 283 ILAEKRGD--LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVI 340 Query: 358 AARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQV 417 R D +Q + +++ I E++R P+ + R + D V+ Y + T + + Sbjct: 341 GERDIKIDD----IQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIIL 396 Query: 418 AIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLI 477 I + R FF P F + KN+ Y FG+G R C G+ IA + M L+ Sbjct: 397 NIGRMHR-LEFFPKPNEFTLENF---AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILV 452 Query: 478 NMLENFRVEI---QHLSDVGTTFNLILMPEKP---ISFTFWPFNQE 517 +L F V+ Q + + +L L P++ + F P N + Sbjct: 453 TLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSD 498 >3IBD-A nrPDB Length = 476 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 51/185 (27%), Positives = 80/185 (43%), Gaps = 18/185 (9%) Query: 309 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAA----RHQAQ 364 S+ S +++ N + G +TTS TL++ M + V + + E+ R Sbjct: 262 SEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPEL 321 Query: 365 GDMATMLQLVPLLKASIKETLR---LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYA 421 D A M P +A I E R L P+ V + R Y+IP T V + + Sbjct: 322 HDRAKM----PYTEAVIYEIQRFSDLLPMGVP--HIVTQHTSFRGYIIPKDTEVFLILST 375 Query: 422 LGREPTFFFDPENFDPTRWLSKD---KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLIN 478 +P +F P+ F+P +L + K F + F G R CLG IA E+ +F Sbjct: 376 ALHDPHYFEKPDAFNPDHFLDANGALKKTEAF--IPFSLGKRICLGEGIARAELFLFFTT 433 Query: 479 MLENF 483 +L+NF Sbjct: 434 ILQNF 438 >4WMZ-A nrPDB Length = 539 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 50/190 (26%), Positives = 85/190 (44%), Gaps = 26/190 (13%) Query: 310 KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMA- 368 KM+ ++I + +L GG T++ T W L +A VQ L E + + ++ Sbjct: 298 KMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTY 357 Query: 369 TMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD--YMIPAKTLVQVAIYALGREP 426 +LQ +PLL +IKETLR+H +L R ++ D+ + + Y+IPA V V+ Sbjct: 358 DLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRD 417 Query: 427 TFFFDPENFDPTRW--------------------LSKDKNITYFRNLGFGWGVRQCLGRR 466 +F + F+ RW +SK + Y L FG G +C+G Sbjct: 418 EYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPY---LPFGGGRHRCIGEH 474 Query: 467 IAELEMTIFL 476 A ++ + + Sbjct: 475 FAYCQLGVLM 484 >5E0E-A nrPDB Length = 463 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 44/183 (24%), Positives = 81/183 (44%), Gaps = 10/183 (5%) Query: 309 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMAR----NLKVQDMLRAEVLAARHQAQ 364 ++ +++ +V + G +T+S TL++ M + KVQ + + + R Sbjct: 253 TEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTL 312 Query: 365 GDMATMLQLVPLLKASIKETLRLHP-ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALG 423 D M P +A I E R I + + + D + R Y++P T V + + Sbjct: 313 EDRTKM----PYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSAL 368 Query: 424 REPTFFFDPENFDPTRWLSKDKNITYFRN-LGFGWGVRQCLGRRIAELEMTIFLINMLEN 482 +P +F P+ F+P +L + + + F G R CLG IA E+ +F +L+N Sbjct: 369 HDPQYFEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQN 428 Query: 483 FRV 485 F + Sbjct: 429 FSL 431 >5E58-A nrPDB Length = 493 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 41/174 (23%), Positives = 76/174 (43%), Gaps = 2/174 (1%) Query: 314 EDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQL 373 +++ +V + G +TTS TL++ M + V + ++ E+ + Sbjct: 286 QNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLEDRTK 345 Query: 374 VPLLKASIKETLRLHPIS-VTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDP 432 +P A I E R ++ + + D + R Y++P T V + + +P +F P Sbjct: 346 MPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQYFEQP 405 Query: 433 ENFDPTRWLSKDKNITYFRN-LGFGWGVRQCLGRRIAELEMTIFLINMLENFRV 485 F+P +L + + + F G R CLG IA E+ +F +L+NF V Sbjct: 406 GTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSV 459 >4GGV-A nrPDB Length = 418 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 51/168 (30%), Positives = 78/168 (46%), Gaps = 28/168 (16%) Query: 318 ANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLL 377 AN+ +L G TT+MTL + + + +V +RA+ LVP Sbjct: 251 ANI--LLVTGHITTTMTLGNTVLCLDADPEVAAKVRAD---------------RSLVP-- 291 Query: 378 KASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDP 437 +I+E LR+ S L R ++ + +IP +V + + A R+P F DPE +DP Sbjct: 292 -GAIEEALRVLSPSAALARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDP 350 Query: 438 TRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRV 485 TR D N + GFG G+ CLG +A LE + L + + F V Sbjct: 351 TR----DPNPHF----GFGRGIHFCLGAPLARLEGRVALNALFDRFPV 390 >3MGX-A nrPDB Length = 415 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 44/189 (23%), Positives = 85/189 (44%), Gaps = 27/189 (14%) Query: 301 ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR 360 ++ L+ D ++ +D+ N +L GG +TT + ++ +A +L A Sbjct: 229 LVSTLVTDDDLTIDDVLLNCDNVLIGGNETTRHAITGAVHALA--------TVPGLLTAL 280 Query: 361 HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIY 420 D+ T+ ++E LR ++ + R D+ + +P+ T V + Sbjct: 281 RDGSADVDTV----------VEEVLRWTSPAMHVLRVTTADVTINGRDLPSGTPVVAWLP 330 Query: 421 ALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML 480 A R+P F DP+ F P R + R++ FG G+ CLG +A +E+++ L + Sbjct: 331 AANRDPAEFDDPDTFLPGRKPN--------RHITFGHGMHHCLGSALARIELSVVLRVLA 382 Query: 481 ENF-RVEIQ 488 E RV+++ Sbjct: 383 ERVSRVDLE 391 >6B11-A nrPDB Length = 440 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 41/143 (28%), Positives = 64/143 (44%), Gaps = 23/143 (16%) Query: 356 VLAARHQAQGDMATMLQLV---------------PLLKASIKETLRLHPISVTLQRYLVN 400 +LAA H+ M TM LV LL ++ E LR I+ L+R Sbjct: 276 LLAAGHETTASMVTMSVLVLLQHPTAWRELTVNPGLLPGAVDELLRYLSIADGLRRSATA 335 Query: 401 DLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVR 460 D+ + + I A + + A R+ F +PE FD R + R++ FG+G Sbjct: 336 DIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHR--------SARRHVAFGYGPH 387 Query: 461 QCLGRRIAELEMTIFLINMLENF 483 QCLG+ +A +E+ + L +LE Sbjct: 388 QCLGQNLARMELEVALGAVLERL 410 >3A1L-A nrPDB Length = 425 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 45/175 (25%), Positives = 72/175 (41%), Gaps = 26/175 (14%) Query: 309 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMA 368 S +S + I +L G +TT+ L + + + V D LR Sbjct: 237 SPLSVDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELR--------------- 281 Query: 369 TMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTF 428 T + P A+++E +R P + R+ D+ L D+ IP + V + + R+P Sbjct: 282 TTPESTP---AAVEELMRYDPPVQAVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDPAR 338 Query: 429 FFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 F DP+ D R R +GFG G+ CLG +A E I L +L+ Sbjct: 339 FPDPDVLDVHRAAE--------RQVGFGLGIHYCLGATLARAEAEIGLRALLDGI 385 >2WIY-A nrPDB Length = 394 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 7/110 (6%) Query: 379 ASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPT 438 A I E +R+ P ++ R+ D+ + +I A + ++ I A R+P F DP+ FD T Sbjct: 268 AIINEMVRMDPPQLSFLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHT 327 Query: 439 RWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF-RVEI 487 R + RNL FG G C G+ I+ E T + E + R+E+ Sbjct: 328 RPPAAS------RNLSFGLGPHSCAGQIISRAEATTVFAVLAERYERIEL 371 >6GK6-A nrPDB Length = 411 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 34/114 (29%), Positives = 58/114 (50%), Gaps = 10/114 (8%) Query: 376 LLKASIKETLRLH-PISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPEN 434 L+ ++++E LR P ++ R+ + D+ L +PA V + A R+P F DP+ Sbjct: 275 LVGSAVEEALRCEGPAELSTIRWSLEDIELFGARVPAGEGVAAGLLAANRDPQHFPDPDR 334 Query: 435 FDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF-RVEI 487 FD + + N R++GFG G+ CLG +A +E I +L R+E+ Sbjct: 335 FD----IGRSPN----RHIGFGGGIHFCLGAMLARIEAAIAFSTLLRRLPRIEL 380 >3SN5-A nrPDB Length = 491 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 91/213 (42%), Gaps = 29/213 (13%) Query: 302 LYRLLGDSKMSFEDIKANVTEML---AGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLA 358 L L D+ +F+D++ T ++ A +T T W L++M RN + EV Sbjct: 242 LRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATF-WSLFQMIRNPEAMKAATEEVKR 300 Query: 359 ARHQA------QGDMATMLQL----VPLLKASIKETLRLHPISVTLQRYLVNDLVLR--- 405 A +G+ + Q +P+L + IKE+LRL S+ + R D L Sbjct: 301 TLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLED 359 Query: 406 -DYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKD--KNITYFRN--------LG 454 Y I ++ + + +P + DP F R+L ++ T++ N + Sbjct: 360 GSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMP 419 Query: 455 FGWGVRQCLGRRIAELEMTIFLINMLENFRVEI 487 FG G C GR A E+ FLI ML F +E+ Sbjct: 420 FGSGATICPGRLFAIHEIKQFLILMLSYFELEL 452 >3NC3-A nrPDB Length = 441 Score = 52.8 bits (125), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 52/184 (28%), Positives = 80/184 (43%), Gaps = 29/184 (15%) Query: 311 MSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATM 370 +S +DI A + +L + TL +Y + N + + +VLA R Sbjct: 254 LSDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMN----DVLADR---------- 299 Query: 371 LQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFF 430 LVP +I ETLR P + R L D V+ I T+V I A R+P F Sbjct: 300 -SLVP---RAIAETLRYKPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFE 355 Query: 431 DPENFDPTRWLSKDKNITY-----FRNLGFGWGVRQCLGRRIAELEMTI---FLINMLEN 482 P+ F+ R +D I R+L FG G+ C+G A+ E+ I +++ + N Sbjct: 356 QPDVFNIHR---EDLGIKSAFSGAARHLAFGSGIHNCVGTAFAKNEIEIVANIVLDKMRN 412 Query: 483 FRVE 486 R+E Sbjct: 413 IRLE 416 >1WIY-A nrPDB Length = 389 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 36/106 (33%), Positives = 53/106 (50%), Gaps = 3/106 (2%) Query: 381 IKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRW 440 +E LRL+P + L R L L+L + +P T + ++ Y R +F + E F P R+ Sbjct: 258 FQEALRLYPPAWILTRRLERPLLLGEDRLPQGTTLVLSPYVTQR--LYFPEGEAFQPERF 315 Query: 441 LSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVE 486 L+ ++ R FG G R CLGR A LE I L FR++ Sbjct: 316 LA-ERGTPSGRYFPFGLGQRLCLGRDFALLEGPIVLRAFFRRFRLD 360 >4Z5P-A nrPDB Length = 400 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 55/199 (27%), Positives = 87/199 (43%), Gaps = 33/199 (16%) Query: 290 QKGSVHHDYRGILYRLLGDSKMSFED--IKANVTEMLAGGVDTTSMTLQWHLYEMARNLK 347 ++ + H D G+L D ED I VT +L G +T++ L +Y + L Sbjct: 200 RRAAPHDDLLGVLVSARDDDDRLTEDELITFGVT-LLVAGHETSAHQLGNMVYAL---LT 255 Query: 348 VQDMLRAEVLAARHQAQGDMATMLQLVP-LLKASIKETLRLHPIS--VTLQRYLVNDLVL 404 +D L ++L+ P LL +++E LR P+ V R + D+ L Sbjct: 256 HEDQL----------------SLLREQPELLPRAVEELLRFVPLGNGVGNARIALEDVEL 299 Query: 405 RDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLG 464 + A V A R+P F DP+ D TR +KN +L FG G CLG Sbjct: 300 SGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITR----EKNP----HLAFGHGAHYCLG 351 Query: 465 RRIAELEMTIFLINMLENF 483 ++A +E+ + + +LE F Sbjct: 352 AQLARMELRVAIGGLLERF 370 >1UE8-A nrPDB Length = 367 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 35/107 (32%), Positives = 52/107 (48%), Gaps = 8/107 (7%) Query: 380 SIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTR 439 +++E LR P + R + +RD +I LV+V I + R+ F DP++F P R Sbjct: 243 AVEEALRFSPPVMRTIRVTKEKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSFIPDR 302 Query: 440 WLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVE 486 T +L FG G+ CLG +A LE I L + FRV+ Sbjct: 303 --------TPNPHLSFGSGIHLCLGAPLARLEARIALEEFAKKFRVK 341 >5VWS-A nrPDB Length = 393 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 61/264 (23%), Positives = 102/264 (38%), Gaps = 42/264 (15%) Query: 247 MLNLPPDLFRLFRTKTWKDHVAAWDV---------IFSKADIYTQNFYWELRQKGSVHHD 297 +L +PP LFRT W D + + V A + N Y + H Sbjct: 143 LLGVPPGDRHLFRT--WSDRLMSLQVENYADPELARTVAAAMTEMNDYLREHCRSRRTHP 200 Query: 298 YRGILYRLLG----DSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLR 353 +L RL+ ++ E++ + +L G TT++ + + + + + + +R Sbjct: 201 RDDLLTRLVQAEVEGKRLDLEEVVNTASLLLLAGHLTTTVLIGNTMLCLWDHPEAEKAVR 260 Query: 354 AEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKT 413 A+ L+ A+++E+LRL + R D+ + IPA Sbjct: 261 ADP------------------SLIPAALEESLRLRSPFLQAGRVTTRDVTIAGETIPANR 302 Query: 414 LVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMT 473 V I + + F DPE FD R + ++ FG GV CLG ++ LE Sbjct: 303 FVMAWILSANHDDRRFPDPERFDLHRQTTG--------HIAFGHGVHFCLGAQLGRLEGR 354 Query: 474 IFLINMLENFRVEIQHLSDVGTTF 497 I L +L F EI G +F Sbjct: 355 IALERLLGRF-TEIHPWPREGISF 377 >5CJE-A nrPDB Length = 393 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 45/183 (24%), Positives = 74/183 (40%), Gaps = 27/183 (14%) Query: 301 ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR 360 I R D ++S E+++A +L G +TT + ++ + + LRA++ Sbjct: 208 IRTRAEDDDRLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRADMT--- 264 Query: 361 HQAQGDMATMLQLVPLLKASIKETLRLH-PISVTLQRYLVNDLVLRDYMIPAKTLVQVAI 419 LL +++E LR P+ RY + + I V + + Sbjct: 265 ---------------LLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPVMIGL 309 Query: 420 YALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINM 479 A GR+P DP FD R +L FG G+ CLG +A LE + L ++ Sbjct: 310 DAAGRDPARHPDPHVFDIHRAPQG--------HLAFGHGIHYCLGAPLARLEARVALRSL 361 Query: 480 LEN 482 LE Sbjct: 362 LER 364 >6F0B-A nrPDB Length = 395 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 40/166 (24%), Positives = 76/166 (45%), Gaps = 27/166 (16%) Query: 308 DSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDM 367 + +++F + + ++ GG DTT+ T+ L A L+ E + H+ Sbjct: 215 EKQLTFHETIGVILMLIVGGYDTTASTISLSLVSYA--------LQPEKFSVVHEHP--- 263 Query: 368 ATMLQLVPLLKASIKETLRLHPIS-VTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREP 426 + +PLL ++E LR H +S + L R D+ + + A +V A+ R+ Sbjct: 264 ----ERIPLL---VEELLRYHTVSQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDE 316 Query: 427 TFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEM 472 + F +P+ D R ++GFG+G QC+G+ +A +E+ Sbjct: 317 SVFPNPDELDFDR--------PSVPHVGFGYGPHQCVGQALARVEL 354 >3JUS-A nrPDB Length = 461 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 53/233 (22%), Positives = 97/233 (41%), Gaps = 10/233 (4%) Query: 284 FYWELRQKGSVHHDYRGILYRLLGDS-----KMSFEDIKANVTEMLAGGVDTTSMTLQWH 338 FY ++++ IL LL + ++ +++ + +L G T+S T W Sbjct: 216 FYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWM 275 Query: 339 LYEMARNLKVQDMLRAEVLAARHQAQGDMA-TMLQLVPLLKASIKETLRLHPISVTLQRY 397 + +AR+ +Q E + + L+ + LL IKETLRL P + + R Sbjct: 276 GFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRM 335 Query: 398 LVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKD-KNITYFRNLGFG 456 + Y IP V V+ R + + +F+P R+L + + F + FG Sbjct: 336 ARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFG 395 Query: 457 WGVRQCLGRRIAELEMTIFLINMLENFRVEI--QHLSDVGTTFNLILMPEKPI 507 G +C+G A +++ ML + ++ + V T +I PE P+ Sbjct: 396 AGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYT-TMIHTPENPV 447 >1ODO-A nrPDB Length = 408 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 37/105 (35%), Positives = 51/105 (48%), Gaps = 10/105 (9%) Query: 381 IKETLRLHPISVTLQ-RYLVNDLVLRDYMIPAKTLVQVAIYALG-REPTFFFDPENFDPT 438 ++ETLR P L RY V D+ L D A+ +A YA R P + D + FD T Sbjct: 279 VEETLRHEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADTFDAT 338 Query: 439 RWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 R T +L FG GV CLG +A +E+T+ L ++ F Sbjct: 339 R--------TVKEHLAFGHGVHFCLGAPLARMEVTLALESLFGRF 375 >4YZR-A nrPDB Length = 405 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 30/123 (24%), Positives = 59/123 (47%), Gaps = 9/123 (7%) Query: 362 QAQGDMATMLQLVPLLKASIKETLR-LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIY 420 Q + + + Q ++ +++E LR P+ + R+ + D + + I ++ + I Sbjct: 259 QHKKECEKLKQQPEMIATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIG 318 Query: 421 ALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML 480 + R+P FF +PE + R + R++ FG+G+ CLG +A LE I +L Sbjct: 319 SANRDPNFFENPEILNINR--------SPNRHISFGFGIHFCLGAPLARLEGHIAFKALL 370 Query: 481 ENF 483 + F Sbjct: 371 KRF 373 >1UED-A nrPDB Length = 406 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 49/231 (21%), Positives = 91/231 (39%), Gaps = 31/231 (13%) Query: 242 HTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWE---LRQKGSVHHDY 298 H +L +P D R F + ++ + + AD N Y + RQ+ Sbjct: 159 HALCELLGIPRDDQREFVRRIRRNADLSRGLKARAADSAAFNRYLDNLLARQRADPDDGL 218 Query: 299 RGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLA 358 G++ R GD+ ++ E++K T ++ GGV+T + + + + + N Sbjct: 219 LGMIVRDHGDN-VTDEELKGLCTALILGGVETVAGMIGFGVLALLDN------------- 264 Query: 359 ARHQAQGDMATMLQLVPLLKASIKETLR-LHPISVTLQRYLVNDLVLRDYMIPAKTLVQV 417 G + + + + + E +R L P+ R + D+V+ +I A V Sbjct: 265 -----PGQIELLFESPEKAERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLC 319 Query: 418 AIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIA 468 +I R+ DP+ D R D +GFG G+ C+G +A Sbjct: 320 SILMANRDEALTPDPDVLDANRAAVSD--------VGFGHGIHYCVGAALA 362 >5FOI-A nrPDB Length = 408 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 45/177 (25%), Positives = 78/177 (44%), Gaps = 27/177 (15%) Query: 300 GILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAA 359 + RLL +++ +++ N +LA G +T++ + L V +LR AA Sbjct: 222 AVTERLL-KGEITHQELVNNAVLLLAAGHETSANQV---------TLSVLTLLRHPETAA 271 Query: 360 RHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAI 419 + Q + L+ ++ E LR H I+ L+R D+VL D+ I A + + + Sbjct: 272 ELREQPE---------LMPNAVDELLRYHSIADGLRRAATADIVLGDHTIRAGDGLIILL 322 Query: 420 YALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFL 476 + + F FD R ++ FG+G QCLG+ +A LEM + L Sbjct: 323 SSANHDGNTFGAEATFDIHR--------PARHHVAFGYGPHQCLGQNLARLEMEVTL 371 >4UBS-A nrPDB Length = 393 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 8/108 (7%) Query: 376 LLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENF 435 L+ A+++E LR I+ L R D+ + I A V A + R+ F +P+ Sbjct: 264 LMPAAVEELLRFLSIADGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDAL 323 Query: 436 DPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 D W ++ ++ FG+G+ QCLG+ +A EM I L + E Sbjct: 324 D---WHRSARH-----HVAFGFGIHQCLGQNLARAEMEIALGTLFERL 363 >3TYW-A nrPDB Length = 417 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 31/106 (29%), Positives = 52/106 (49%), Gaps = 9/106 (8%) Query: 376 LLKASIKETLRLHPISVTLQ-RYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPEN 434 L+ A++ E LR+ ++ ++ R D+ L +PA V + +P F DPE Sbjct: 281 LMPAAVDELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPER 340 Query: 435 FDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML 480 D R T ++ FG+GV QC+G+ +A LE+ + L +L Sbjct: 341 VDFHR--------TDNHHVAFGYGVHQCVGQHLARLELEVALETLL 378 >2Y5N-A nrPDB Length = 417 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 34/110 (30%), Positives = 52/110 (47%), Gaps = 10/110 (9%) Query: 376 LLKASIKETLRLHPISV--TLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPE 433 L+ ++++E R P+ V RY V D+ LR I A V + A R+ F D + Sbjct: 286 LIPSAVEELTRWVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDAD 345 Query: 434 NFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 D R T ++LGFG GV CLG +A +E+ + L +L+ Sbjct: 346 RIDVDR--------TPNQHLGFGHGVHHCLGAPLARVELQVALEVLLQRL 387 >3TKT-A nrPDB Length = 450 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 33/106 (31%), Positives = 46/106 (43%), Gaps = 8/106 (7%) Query: 376 LLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENF 435 LL ++E +R R D L I A + + A +P F +P F Sbjct: 321 LLPGIVEEAIRWTTPVQHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKF 380 Query: 436 DPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLE 481 DPTR + R+L FG G QCLG +A LEM + L +L+ Sbjct: 381 DPTRPAN--------RHLAFGAGSHQCLGLHLARLEMRVLLDVLLD 418 >4JBT-A nrPDB Length = 410 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 46/186 (24%), Positives = 84/186 (45%), Gaps = 27/186 (14%) Query: 300 GILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAA 359 ++Y G++ ++ E++ N+ ++A G +TT + + + + + ++R Sbjct: 218 ALIYATDGETPLTEEEVIGNLQALVAAGHETTVSLILTAVRALLSHPEQLRLVR------ 271 Query: 360 RHQAQGDMATMLQLVPLLKASIKETLRLH-PISVTLQRYLVNDLVLRDYMIPAKTLVQVA 418 G++ + +I+ETLR P+ L R+ D+ L D +IP V ++ Sbjct: 272 ----DGEIG--------WETAIEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMS 319 Query: 419 IYALGREPTFF-FDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLI 477 A+GR+ T D ++FD TR T R++ FG G C G +A LE I L Sbjct: 320 YRAIGRDITVHGADADDFDITR-------ATAARHISFGHGPHICPGAALARLEAAIALP 372 Query: 478 NMLENF 483 + F Sbjct: 373 ALFTRF 378 >2WIO-A nrPDB Length = 431 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 31/107 (28%), Positives = 46/107 (42%), Gaps = 6/107 (5%) Query: 377 LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFD 436 + A ++E LR P +QR + IPA +V + + R+ DP+ FD Sbjct: 294 IPAIVEEVLRYRPPFPQMQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFD 353 Query: 437 PTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 P+R L FG GV CLG +A LE + L ++ F Sbjct: 354 PSR------KSGGAAQLSFGHGVHFCLGAPLARLENRVALEEIIARF 394 >1Z8P-A nrPDB Length = 404 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 33/107 (30%), Positives = 49/107 (45%), Gaps = 8/107 (7%) Query: 377 LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFD 436 L +++E LR T R+ ++ + IP + V VA A R+P F DP FD Sbjct: 274 LPNAVEEILRYIAPPETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRFD 333 Query: 437 PTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 TR +L FG G+ C+GR +A+LE + L + F Sbjct: 334 VTRDTRG--------HLSFGQGIHFCMGRPLAKLEGEVALRALFGRF 372 >2VZM-A nrPDB Length = 436 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 44/174 (25%), Positives = 72/174 (41%), Gaps = 27/174 (15%) Query: 309 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMA 368 S+++ E++ +L G +TT + +Y + + LRA++ Sbjct: 246 SRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMT----------- 294 Query: 369 TMLQLVPLLKASIKETLRLH-PISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPT 427 LL +++E LR P+ R+ V + L +IPA V V + R P Sbjct: 295 -------LLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPE 347 Query: 428 FFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLE 481 F DP FD R + +L FG G+ C+G +A LE I + +LE Sbjct: 348 RFPDPHRFDIRRDTAG--------HLAFGHGIHFCIGAPLARLEARIAVRALLE 393 >6GII-A nrPDB Length = 479 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 30/125 (24%), Positives = 55/125 (44%), Gaps = 11/125 (8%) Query: 376 LLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENF 435 L+ A+ +E LR + +R ++ + +P + + + + + F DPE F Sbjct: 340 LIPAAAEECLRYNGPVAGWRRRTTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFF 399 Query: 436 DPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGT 495 D R + + +L FG+G QCLGR + +EM I M+E + H+ Sbjct: 400 DIGRSNASE-------HLNFGYGAHQCLGRNLGRMEMQI----MIEELSRRLPHMRLAEQ 448 Query: 496 TFNLI 500 F+ + Sbjct: 449 RFDYL 453 >2FR7-A nrPDB Length = 412 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 47/199 (23%), Positives = 82/199 (41%), Gaps = 27/199 (13%) Query: 282 QNFYWELRQKGSVHHDYRGILYRLLGDS-KMSFEDIKANVTEMLAGGVDTTSMTLQWHLY 340 Q + E Q+ ++ G D+ +++ E+ V +L+ G+DTT + +Y Sbjct: 206 QAYVAEQCQRPNLAPGGFGACIHAFSDTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVY 265 Query: 341 EMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVN 400 +AR LRA+ AR+ + +E +R T R Sbjct: 266 CLARFPDEFARLRADPSLARN------------------AFEEAVRFESPVQTFFRTTTR 307 Query: 401 DLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVR 460 D+ L I V + + + R+P + DP+ +D TR S ++GFG GV Sbjct: 308 DVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRYDITRKTSG--------HVGFGSGVH 359 Query: 461 QCLGRRIAELEMTIFLINM 479 C+G+ +A LE + L + Sbjct: 360 MCVGQLVARLEGEVVLAAL 378 >6CR2-A nrPDB Length = 477 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 48/197 (24%), Positives = 79/197 (40%), Gaps = 32/197 (16%) Query: 314 EDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATM--- 370 E+I + +L G ++S T W + +A + + L E + D+ + Sbjct: 249 EEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRV---LGSDLPPLTYD 305 Query: 371 -LQLVPLLKASIKETLRLHPISVTLQRYLVNDLVL--RDYMIPAKTLVQVAIYALGREPT 427 LQ + L IKETLRLH ++ R + N + + Y+IP V + R Sbjct: 306 NLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEE 365 Query: 428 FFFDPENFDPTRW--------------------LSKDKNITYFRNLGFGWGVRQCLGRRI 467 F +P ++P RW +SK N Y L FG G +C+G + Sbjct: 366 HFPNPLEWNPHRWDENIAASAEDDEKVDYGYGLVSKGTNSPY---LPFGAGRHRCIGEQF 422 Query: 468 AELEMTIFLINMLENFR 484 A L++ ++ FR Sbjct: 423 AYLQLGTITAVLVRLFR 439 >6GMF-A nrPDB Length = 397 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 42/137 (30%), Positives = 67/137 (48%), Gaps = 19/137 (13%) Query: 355 EVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTL 414 E LAA AQ D L LVP A ++E LR + + R + D+ + D IPA+++ Sbjct: 254 EQLAA---AQAD----LSLVP---AVVEEVLRYESPAQCIFRQTMTDVEIGDERIPARSV 303 Query: 415 VQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTI 474 V + + R+ + F DP+ FD + +D +L FG + C+G +A LE + Sbjct: 304 VLPLLASANRDESRFPDPDRFD----IHRDTK----GHLAFGLDIHFCIGAPLARLEAKV 355 Query: 475 FLINMLENFRVEIQHLS 491 L +L +IQ +S Sbjct: 356 MLEVLLARLG-DIQRVS 371 >2RFC-A nrPDB Length = 343 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 34/111 (30%), Positives = 55/111 (49%), Gaps = 11/111 (9%) Query: 381 IKETLRLH-PISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTR 439 ++ETLR + PI R+ D + + I V V + + R+ TFF +P+ F R Sbjct: 222 VEETLRYYSPIQFLPHRFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFDEPDLFKIGR 281 Query: 440 WLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF-RVEIQH 489 +L FG G+ CLG +A LE +I L ++L +F R++I + Sbjct: 282 RE---------MHLAFGIGIHMCLGAPLARLEASIALNDILNHFKRIKIDY 323 >6HQW-A nrPDB Length = 445 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 42/196 (21%), Positives = 81/196 (41%), Gaps = 25/196 (12%) Query: 286 WELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARN 345 W R + D ++ + MS ++ N+ ++ GG DTT T+ ++ + + Sbjct: 243 WGARMQAPPSGDLISMMIHSEAMNHMSPQEFMGNLVLLIVGGNDTTRNTMSGIVHALDKF 302 Query: 346 LKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLR 405 +++L + L+ +++E +R ++R D L Sbjct: 303 PDQRELLERDA------------------SLIPNAVQECIRYVTPLAHMRRTATADTELF 344 Query: 406 DYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGR 465 I A V + + R+ T F +P+ R ++ R+L FG G+ +C+G Sbjct: 345 GNQIKAGEKVILWYISANRDETVFENPDKLMVDRPNAR-------RHLSFGHGIHRCVGA 397 Query: 466 RIAELEMTIFLINMLE 481 R+AEL++ I L M E Sbjct: 398 RLAELQLRILLEEMHE 413 >5NWS-A nrPDB Length = 435 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 30/109 (27%), Positives = 48/109 (44%), Gaps = 5/109 (4%) Query: 376 LLKASIKETLR-LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPEN 434 LL ++ E +R + V RY DL L + VQ+ + + +P + DP+ Sbjct: 299 LLPRAVHELMRWCGSVHVARLRYATEDLELAGTPVARGDAVQLVLVSANFDPRHYSDPDR 358 Query: 435 FDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 D TR ++GFG G+ CLG +A E + L +LE + Sbjct: 359 LDITRHQEGQAE----NHVGFGHGIHYCLGATLARQEGEVALARLLETY 403 >4WPZ-A nrPDB Length = 397 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 45/181 (24%), Positives = 78/181 (43%), Gaps = 30/181 (16%) Query: 307 GDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGD 366 GDS ++ +I A +L+ G +TT+ + L + N + D LR A Sbjct: 213 GDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLHNPEELDKLRDNREA-------- 264 Query: 367 MATMLQLVPLLKASIKETLRLHPISVT---LQRYLVNDLVLRD-YMIPAKTLVQVAIYAL 422 + ++ E LR P++ T + R ++ L ++PA +V A+ Sbjct: 265 ----------IPKAVDELLRFVPLTTTGGIIPRLTTAEVELSGGQVLPAGAVVLPAVATA 314 Query: 423 GREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLEN 482 R+P F D E + TR + N +L FG G+ CLG ++A +E+ L +L+ Sbjct: 315 NRDPEVFEDGERLNVTR----ENN----PHLAFGAGIHHCLGAQLARIELQEALGAILDR 366 Query: 483 F 483 Sbjct: 367 M 367 >6A7J-A nrPDB Length = 411 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 35/104 (33%), Positives = 50/104 (48%), Gaps = 8/104 (7%) Query: 381 IKETLRLH-PISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTR 439 I+ETLR + P S L R+ D+ + D ++P + V+ ALGR D E + PT Sbjct: 277 IEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGR------DEEQYGPTA 330 Query: 440 WLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 D T R++ FG G C G ++ LE I L + E F Sbjct: 331 G-DFDATRTPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERF 373 >3ABB-A nrPDB Length = 408 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 47/100 (47%), Gaps = 8/100 (8%) Query: 377 LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFD 436 + ++E LR +S + R D+ + I A V V+I + R+ + +P+ FD Sbjct: 276 VSGVVEELLRFTSVSDHIVRMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFD 335 Query: 437 PTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFL 476 R ++GFG G+ QCLG+ +A E+ I L Sbjct: 336 ARR--------NARHHVGFGHGIHQCLGQNLARAELEIAL 367 >3P3Z-A nrPDB Length = 416 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 45/193 (23%), Positives = 76/193 (39%), Gaps = 40/193 (20%) Query: 289 RQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARN--- 345 ++K D + R D + +++ V +L G +TT+ L +Y+ A++ Sbjct: 216 KRKVEPGDDLTSDIVRAFHDGVLDDYELRTLVATVLVAGYETTNHQLALAMYDFAQHPDQ 275 Query: 346 -LKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHP-ISVTLQRYLVNDLV 403 +K+++ L +++E LR P + VT R D Sbjct: 276 WMKIKENPE----------------------LAPQAVEEVLRWSPTLPVTATRVAAEDFE 313 Query: 404 LRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFR---NLGFGWGVR 460 + IP T V + + R+P F D + FD IT R ++ FG G Sbjct: 314 VNGVRIPTGTPVFMCAHVAHRDPRVFADADRFD----------ITVKREAPSIAFGGGPH 363 Query: 461 QCLGRRIAELEMT 473 CLG +A LE+T Sbjct: 364 FCLGTALARLELT 376 >5XW2-A nrPDB Length = 419 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 33/109 (30%), Positives = 55/109 (50%), Gaps = 10/109 (9%) Query: 376 LLKASIKETLR-LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPEN 434 L+ ++E++R L P++ T R D+ + + A +V V A R+ F +PE Sbjct: 288 LIPGLLEESMRFLSPVAATY-RATTRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPEL 346 Query: 435 FDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 FD TR + +LGFG G+ CLG +A +E + L ++L+ F Sbjct: 347 FDMTRGPNP--------HLGFGRGIHFCLGGPLARMEGRVALDHLLDRF 387 >6A7I-A nrPDB Length = 411 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 34/104 (32%), Positives = 50/104 (48%), Gaps = 8/104 (7%) Query: 381 IKETLRLH-PISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTR 439 I+ETLR + P S L R+ D+ + D ++P + ++ ALGR D E + PT Sbjct: 277 IEETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGALGR------DEEQYGPTA 330 Query: 440 WLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 D T R++ FG G C G ++ LE I L + E F Sbjct: 331 G-EFDATRTPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERF 373 >4OQR-A nrPDB Length = 457 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 25/91 (27%), Positives = 42/91 (46%), Gaps = 7/91 (7%) Query: 393 TLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRN 452 T R + D+ L MI V + + A+ R+P F +P+ R + ++ Sbjct: 325 TPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR-------VDARKH 377 Query: 453 LGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 FG G+ QCLG+++A +EM I + F Sbjct: 378 AAFGGGIHQCLGQQLARVEMRIGFTRLFARF 408 >1EHE-A nrPDB Length = 403 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 42/179 (23%), Positives = 78/179 (43%), Gaps = 21/179 (11%) Query: 309 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLA-ARHQAQGDM 367 SK+ E +K G +D + L +A N + +M+ V A+H D Sbjct: 212 SKLCTEQVKP-------GNIDKSDAVQIAFLLLVAGNATMVNMIALGVATLAQHP---DQ 261 Query: 368 ATMLQLVPLLKAS-IKETLRLHPIS-VTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGRE 425 L+ P L ++E R H S + ++R D+++ D ++ A + + + R+ Sbjct: 262 LAQLKANPSLAPQFVEELCRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRD 321 Query: 426 PTFFFDPENFDPTR-WLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 F +P+ F+ R W +D LGFG+G +C+ +A+ E+T + + F Sbjct: 322 EEVFENPDEFNMNRKWPPQDP-------LGFGFGDHRCIAEHLAKAELTTVFSTLYQKF 373 >6HQG-A nrPDB Length = 425 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 43/177 (24%), Positives = 77/177 (43%), Gaps = 14/177 (7%) Query: 317 KANVTEMLAGGVDTTSMTLQWHLYEM-----ARNLKVQDMLRAEVLAARHQAQGDMATML 371 K ++ MLA G T +M +L + N ++ + VLA HQ + Sbjct: 231 KPDLISMLAHGESTKNMDRMEYLGNLILLIVGGNDTTRNTISGSVLAL-HQNPDQDRKLR 289 Query: 372 QLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFD 431 + L+ A + ET+R ++R D L I V + + R+ Sbjct: 290 ENPGLIPAMVSETIRWQTPLAYMRRRAKRDFELGGKTIREGDKVAMWYVSGNRDEEVIDR 349 Query: 432 PENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF-RVEI 487 P ++ W+ + + ++L FG+GV +C+G R+AEL++ I +L F R+E+ Sbjct: 350 PNDY----WIERPR---VRQHLSFGFGVHRCVGNRLAELQLKIIWEEILARFPRLEV 399 >5LIE-A nrPDB Length = 414 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 41/161 (25%), Positives = 65/161 (40%), Gaps = 26/161 (16%) Query: 323 MLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIK 382 + + G +TT ++ L +A N LR++ LL +I+ Sbjct: 250 LFSAGAETTRNSIAGGLLALAENPDQLQTLRSDF------------------ELLPTAIE 291 Query: 383 ETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLS 442 E +R S + +R + L I A V V + R+P+ F + FD TR + Sbjct: 292 EIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITRKPN 351 Query: 443 KDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 +LGFG GV CLG +A LE+ + +L F Sbjct: 352 P--------HLGFGQGVHYCLGANLARLELRVLFEELLSRF 384 >2ZBZ-A nrPDB Length = 412 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 30/107 (28%), Positives = 52/107 (48%), Gaps = 9/107 (8%) Query: 376 LLKASIKETLRLHPIS-VTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPEN 434 L+ +++E LR I+ + R D+ + +I A V V R+ T + DP+ Sbjct: 276 LVPGAVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTVYEDPDA 335 Query: 435 FDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLE 481 D R + +L FG+GV QCLG+ +A LE+ + L +++ Sbjct: 336 LDIHR--------SARHHLAFGFGVHQCLGQNLARLELEVILNALMD 374 >3A50-A nrPDB Length = 411 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 29/97 (29%), Positives = 48/97 (49%), Gaps = 9/97 (9%) Query: 376 LLKASIKETLRL-HPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPEN 434 L+ ++++E LR P+S R+ D+ IPA +V + + A R+ + +P+ Sbjct: 268 LISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDR 327 Query: 435 FDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELE 471 D TR D + F FG G+ CLG ++A LE Sbjct: 328 LDITR----DASGGVF----FGHGIHFCLGAQLARLE 356 >4OQS-A nrPDB Length = 433 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 25/91 (27%), Positives = 42/91 (46%), Gaps = 7/91 (7%) Query: 393 TLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRN 452 T R + D+ L MI V + + A+ R+P F +P+ R + ++ Sbjct: 286 TPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR-------VDARKH 338 Query: 453 LGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 FG G+ QCLG+++A +EM I + F Sbjct: 339 AAFGGGIHQCLGQQLARVEMRIGFTRLFARF 369 >3WVS-A nrPDB Length = 401 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 32/110 (29%), Positives = 51/110 (46%), Gaps = 10/110 (9%) Query: 376 LLKASIKETLRLHPISV--TLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPE 433 L+ ++++E R P+ RY D+ + ++ A V VA+ A R+ F DPE Sbjct: 273 LIPSAVEELFRFVPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVALGAANRDGLRFEDPE 332 Query: 434 NFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 L + N ++GFG G+ CLG +A LE+ L +LE Sbjct: 333 EIK----LDRPSN----HHIGFGHGIHHCLGAPLARLELQEALRALLERL 374 >4DO1-A nrPDB Length = 410 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 39/157 (24%), Positives = 67/157 (42%), Gaps = 26/157 (16%) Query: 320 VTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKA 379 V +L+ G+DTT + +Y +AR LR++ AR+ Sbjct: 243 VRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARN------------------ 284 Query: 380 SIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTR 439 + +E +R T R ++ L +I V + + + R+P + DP+ +D TR Sbjct: 285 AFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITR 344 Query: 440 WLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFL 476 S ++GFG GV C+G+ +A LE + L Sbjct: 345 KTSG--------HVGFGSGVHMCVGQLVARLEGEVML 373 >4RM4-A nrPDB Length = 396 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 39/174 (22%), Positives = 71/174 (40%), Gaps = 26/174 (14%) Query: 310 KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMAT 369 K+S E++ T +L G +TT+ + +Y + V + LR+ Sbjct: 223 KLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHP------------- 269 Query: 370 MLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFF 429 L+ +++E LR + L+R D + ++I +V + + R+ F Sbjct: 270 -----ELMPQAVEEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKF 324 Query: 430 FDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 P FD R + ++ FG G+ CLG +A LE I L +++ F Sbjct: 325 DRPHMFDIRRHPNP--------HIAFGHGIHFCLGAPLARLEANIALTSLISAF 370 >5IT1-A nrPDB Length = 399 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 33/120 (27%), Positives = 53/120 (44%), Gaps = 10/120 (8%) Query: 366 DMATMLQLVP-LLKASIKETLRLHPIS-VTLQRYLVNDLVLRDYMIPAKTLVQVAIYALG 423 D +LQ P L+ +++E LR I +R D + I V + + Sbjct: 258 DQLALLQKDPSLIGNAVEELLRYLTIGQFGAERVATQDGEIGGVRIAKGEQVVTHLLSAD 317 Query: 424 REPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 +P F DPE FD TR + +L FG+G QC+G+++A +E+ I + F Sbjct: 318 FDPAFVEDPERFDITRRPAP--------HLAFGFGAHQCIGQQLARIELQIVFGTLFRRF 369 >3RWL-A nrPDB Length = 426 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 53/226 (23%), Positives = 92/226 (40%), Gaps = 32/226 (14%) Query: 267 VAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDS----KMSFEDIKANVTE 322 V +WD K ++ Y+++ V+ D L +L S M+ E+ NV Sbjct: 204 VESWDQ--RKTELLECAAYFQVLWNERVNKDPGNDLISMLAHSPATRNMTPEEYLGNVLL 261 Query: 323 MLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIK 382 ++ GG DTT RN +L A H+ A + L++ + Sbjct: 262 LIVGGNDTT------------RNSMTGGVL------ALHKNPDQFAKLKANPALVETMVP 303 Query: 383 ETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLS 442 E +R ++R + D L I V + Y+ R+ PE F R Sbjct: 304 EIIRWQTPLAHMRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDRPRP 363 Query: 443 KDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF-RVEI 487 + ++L FG+G+ +C+G R+AE+++ I +L F R+E+ Sbjct: 364 R-------QHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFSRIEV 402 >5HDI-A nrPDB Length = 404 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 39/127 (30%), Positives = 56/127 (44%), Gaps = 9/127 (7%) Query: 376 LLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENF 435 LL A I+ETLR P R++ N L +PA + + + A R+P F P F Sbjct: 276 LLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEF 335 Query: 436 DPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGT 495 R K ++ FG G C+G +A LE I L +L+ R + +DVG Sbjct: 336 RLDRAGGKG-------HISFGKGAHFCVGAALARLEARIVLRLLLD--RTSVIEAADVGG 386 Query: 496 TFNLILM 502 IL+ Sbjct: 387 WLPSILV 393 >4TRI-A nrPDB Length = 407 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 41/166 (24%), Positives = 70/166 (42%), Gaps = 26/166 (15%) Query: 310 KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMAT 369 +MS ++I +L GG +TT TL ++ R+ D L A+V Sbjct: 217 RMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADV------------- 263 Query: 370 MLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFF 429 LL +I+E LR + R L D V + A + + + + + F Sbjct: 264 -----DLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVF 318 Query: 430 FDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIF 475 DP+NF + ++ N ++ FG+G CLG ++A LE+ + Sbjct: 319 GDPDNF----RIDRNPN----SHVAFGFGTHFCLGNQLARLELRLM 356 >1Q5D-A nrPDB Length = 419 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 51/228 (22%), Positives = 96/228 (42%), Gaps = 37/228 (16%) Query: 289 RQKGSVHHDYRGILYRLLGD-SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLK 347 R++ + +D +L + D S++S +++ A V ++A G DTT + + + + R+ + Sbjct: 216 RRRNPLENDVLTMLLQAEADGSRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPE 275 Query: 348 VQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPI-SVTLQRYLVNDLVLRD 406 ++++AE L++ ++ E LR I + R+ DL Sbjct: 276 ALELVKAE------------------PGLMRNALDEVLRFDNILRIGTVRFARQDLEYCG 317 Query: 407 YMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRR 466 I +V + I + R+ T F P+ FD R S +L +G G C G Sbjct: 318 ASIKKGEMVFLLIPSALRDGTVFSRPDVFDVRRDTSA--------SLAYGRGPHVCPGVS 369 Query: 467 IAELEMTIFLINMLENF-RVEIQHLSDVG--------TTFNLILMPEK 505 +A LE I + + F ++++ G + N+IL P K Sbjct: 370 LARLEAEIAVGTIFRRFPEMKLKETPVFGYHPAFRNIESLNVILKPSK 417 >5EX6-C nrPDB Length = 434 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 41/177 (23%), Positives = 68/177 (38%), Gaps = 26/177 (14%) Query: 307 GDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGD 366 GD+ ++ E+++ +M+ G D S + + + RN + LR +V AA Sbjct: 254 GDT-VTDEELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAALRGDVPAAERAVD-- 310 Query: 367 MATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREP 426 +L+ L T R + D + D +I A V ++ R+P Sbjct: 311 -----ELIRYLTVPYAPT----------PRTAIEDSTVGDQVIKAGETVLCSLPTANRDP 355 Query: 427 TFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 D + D TR ++ FG GV CLG +A LE+ I + F Sbjct: 356 ALLPDADRLDVTR--------EAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRF 404 >5YSW-A nrPDB Length = 441 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 46/194 (23%), Positives = 82/194 (42%), Gaps = 35/194 (18%) Query: 300 GILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAA 359 G+++ D ++ +++ +L G DTT+ L ++ + Sbjct: 251 GLIHHAGADPALTDDELINIANLLLIAGYDTTASMLGLGIFVLL---------------- 294 Query: 360 RHQAQGDMATMLQLVPLLKASIKETLR-LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVA 418 Q +AT+ + +++E LR L ++ + R+ DL IPA + V V+ Sbjct: 295 --QRPAQLATLRDDPSRIADAVEELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVS 352 Query: 419 IYALGREPTFFFDPENFDPTRWLSKDKNITYFR--NLGFGWGVRQCLGRRIAELEMTIF- 475 + A R D W D ++T R +L FG GV QCLG+++A +EM Sbjct: 353 VVATNR-----------DARHWPDPDLDLTRPRGPHLAFGHGVHQCLGQQLARMEMQAGY 401 Query: 476 --LINMLENFRVEI 487 L+ L N R+ + Sbjct: 402 AELLRRLPNVRLAV 415 >2XKR-A nrPDB Length = 398 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 44/200 (22%), Positives = 83/200 (41%), Gaps = 33/200 (16%) Query: 310 KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMAT 369 ++S +++ +L GG +TT TL ++ RN D+L+ + Sbjct: 214 RLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDP------------- 260 Query: 370 MLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFF 429 LL +I+E LR + R L D + A + + + + F Sbjct: 261 -----SLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVF 315 Query: 430 FDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQH 489 +PE FD + ++ N +L FG+G CLG ++A LE+++ +L + Sbjct: 316 CEPEKFD----VQRNPN----SHLAFGFGTHFCLGNQLARLELSLMTERVL-------RR 360 Query: 490 LSDVGTTFNLILMPEKPISF 509 L D+ + ++P +P +F Sbjct: 361 LPDLRLVADDSVLPLRPANF 380 >5FYF-A nrPDB Length = 470 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 42/167 (25%), Positives = 75/167 (44%), Gaps = 27/167 (16%) Query: 318 ANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLL 377 N+T ++ GG DTT ++ L M + + L+A+ +L+P + Sbjct: 299 GNLTLLIVGGNDTTRNSMSGGLVAMNEFPREFEKLKAKP---------------ELIPNM 343 Query: 378 KASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALG-REPTFFFDPENFD 436 + E +R ++R D+ L I V V YA G R+ F +P+ F Sbjct: 344 ---VSEIIRWQTPLAYMRRIAKQDVELGGQTIKKGDRV-VMWYASGNRDERKFDNPDQFI 399 Query: 437 PTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 R +++ ++ FG+GV +C+G R+AEL++ I +L+ F Sbjct: 400 IDRKDARN-------HMSFGYGVHRCMGNRLAELQLRILWEEILKRF 439 >3OFT-A nrPDB Length = 396 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 39/178 (21%), Positives = 74/178 (41%), Gaps = 29/178 (16%) Query: 301 ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR 360 IL +G + ++ + +L GG+DT + + +AR+ + Q +LR Sbjct: 209 ILSEPVGGRPWTVDEARRMCRNLLFGGLDTVAAMIGMVALHLARHPEDQRLLR------- 261 Query: 361 HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIY 420 + L+ A+ E +R +P +V + R V D+ I LV + Sbjct: 262 -----------ERPDLIPAAADELMRRYP-TVAVSRNAVADVDADGVTIRKGDLVYL--- 306 Query: 421 ALGREPTFF--FDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFL 476 P+ DP +F+ + D+ + R+ G G +C+G +A +E+ +FL Sbjct: 307 -----PSVLHNLDPASFEAPEEVRFDRGLAPIRHTTMGVGAHRCVGAGLARMEVIVFL 359 >2NZA-A nrPDB Length = 413 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 34/119 (28%), Positives = 52/119 (43%), Gaps = 10/119 (8%) Query: 367 MATMLQLVPLLKASIKETLR--LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGR 424 MA M + ++ E LR H SV L R + D+ + I A V V+ A R Sbjct: 267 MARMRERPGARGTALDELLRWISHRTSVGLARIALEDVEVHGTRIAAGEPVYVSYLAANR 326 Query: 425 EPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 +P F DP+ D L +D N +L +G G C G +A ++ + + +LE Sbjct: 327 DPDVFPDPDRID----LDRDPNP----HLAYGNGHHFCTGAVLARMQTELLVDTLLERL 377 >5L1U-A nrPDB Length = 401 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 34/119 (28%), Positives = 54/119 (45%), Gaps = 14/119 (11%) Query: 376 LLKASIKETLRL----HPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFD 431 L A+++E LRL + + RY D+ + + +I V +AI A + F D Sbjct: 267 LAPAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPD 326 Query: 432 PENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIF---LINMLENFRVEI 487 FD TR + +L FG G R C+GR +A +E+T L L + R+ + Sbjct: 327 GGLFDLTRVRPRS-------HLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLRLAV 378 >5L94-A nrPDB Length = 410 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 37/136 (27%), Positives = 59/136 (43%), Gaps = 18/136 (13%) Query: 376 LLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENF 435 LL + I+E LR L R + D+ L + A V + + R+ +F DPE F Sbjct: 274 LLPSGIEEVLRYRSPVQALHRIVKEDVTLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVF 333 Query: 436 DPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGT 495 + + N+ ++ FG G+ CLG +A +E I L +++ + D Sbjct: 334 K----IDRKPNV----HMAFGRGIHFCLGAPLARIEAKIMLAELIDRY-----PQMDWSP 380 Query: 496 TFNLILMPEKPISFTF 511 +F L KPI TF Sbjct: 381 SFEL-----KPIESTF 391 >3EJB-B nrPDB Length = 404 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 29/106 (27%), Positives = 48/106 (45%), Gaps = 8/106 (7%) Query: 376 LLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENF 435 L+ +++E LR + R D+ + I V + + A R+P+ F +P+ F Sbjct: 266 LIGTAVEECLRYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVF 325 Query: 436 DPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLE 481 D TR + +L FG G CLG +A LE I + +L+ Sbjct: 326 DITRSPNP--------HLSFGHGHHVCLGSSLARLEAQIAINTLLQ 363 >3ABA-A nrPDB Length = 403 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 29/100 (29%), Positives = 47/100 (47%), Gaps = 9/100 (9%) Query: 376 LLKASIKETLRLHPIS-VTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPEN 434 L+ +++E LR I +R D+ L I V + A +P F +PE Sbjct: 269 LVGNAVEELLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPER 328 Query: 435 FDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTI 474 FD TR + +L FG+G QC+G+++A +E+ I Sbjct: 329 FDITRRPAP--------HLAFGFGAHQCIGQQLARIELQI 360 >6G71-A nrPDB Length = 405 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 40/159 (25%), Positives = 69/159 (43%), Gaps = 28/159 (17%) Query: 307 GDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGD 366 D +M E I++N+ + GG++ + +D+L LA ++ Sbjct: 217 ADYQMPLESIRSNIKMTIGGGLN-----------------EPRDVLGVSTLALLSSSK-Q 258 Query: 367 MATMLQLVPLLKASIKETLR-LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGRE 425 + +L+ L A +E++R + PI + + R V D L Y IP + + I + R+ Sbjct: 259 LELVLRDPKLWGAVFEESIRWVAPIGM-VPRQTVVDTELDGYFIPRGAKLGLCILSANRD 317 Query: 426 PTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLG 464 + + DP+ FD R +L FG GV CLG Sbjct: 318 RSVWSDPDRFDIER--------GSEAHLAFGKGVHVCLG 348 >1GWI-A nrPDB Length = 411 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 33/108 (30%), Positives = 50/108 (46%), Gaps = 9/108 (8%) Query: 378 KASIKETLRLH-PISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGR-EPTFFFDPENF 435 A ++ETLR P S L R+ D+ + D +IPA + V+ ALGR E + F Sbjct: 276 SAVVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADRF 335 Query: 436 DPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 D TR + R++ FG G C G ++ +E + L + F Sbjct: 336 DLTR-------TSGNRHISFGHGPHVCPGAALSRMEAGVALPALYARF 376 >6HQD-A nrPDB Length = 420 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 30/113 (26%), Positives = 52/113 (46%), Gaps = 8/113 (7%) Query: 376 LLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENF 435 LL + I E +R ++R + D+ R I V + + R+ P +F Sbjct: 291 LLASVIPEVVRWQTPIAHMRRTALEDVEFRGKQIRKGDKVVMWYLSGNRDDEVIDRPMDF 350 Query: 436 DPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF-RVEI 487 R ++ +L FG+G+ +CLG R+AEL++ I M E + R+E+ Sbjct: 351 IADRPRAR-------HHLSFGFGIHRCLGNRLAELQLKILWEEMCERYSRIEV 396 >4MM0-A nrPDB Length = 399 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 29/109 (26%), Positives = 50/109 (45%), Gaps = 9/109 (8%) Query: 376 LLKASIKETLRLHPIS-VTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPEN 434 LL ++++E +R P L R + D+ + D IPA + V + A +P F DP Sbjct: 268 LLPSAVEELMRYAPAGDGALFRVTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTG 327 Query: 435 FDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 L + N ++ G G+ CLG +A +E+ + + +L F Sbjct: 328 L----RLDRPDN----QHTALGHGIHFCLGAALARVELQVAIGALLRRF 368 >5OFQ-A nrPDB Length = 409 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 49/225 (21%), Positives = 92/225 (40%), Gaps = 32/225 (14%) Query: 279 IYTQNFYWEL---RQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTL 335 I+ Q ++ E+ RQ+ +L + ++ E++ +L G +TT+ + Sbjct: 191 IFLQGYFKEIIAERQQNKQEDLISLLLEAEIDGEHLTEEEVLGFCILLLVAGNETTTNLI 250 Query: 336 QWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQ 395 + M ++ VQ+ +R ++ LVP L ++ETLR +P + Sbjct: 251 TNGVRYMTEDVDVQNEVRRDI---------------SLVPNL---VEETLRYYPPIQAIG 292 Query: 396 RYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGF 455 R D+ L + I V + R+ F P+ F R + ++ F Sbjct: 293 RIAAEDVELGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHRKTNP--------HVSF 344 Query: 456 GWGVRQCLGRRIAELEMTIFLINMLEN---FRVEIQHLSDVGTTF 497 G+G+ CLG +A +E I +LE +V+ Q L + + F Sbjct: 345 GFGIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPIDSPF 389 >1F4U-A nrPDB Length = 368 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 35/108 (32%), Positives = 47/108 (43%), Gaps = 9/108 (8%) Query: 377 LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFD 436 LKA I+E LR P + R + L D I V+V I + R+ F D E F Sbjct: 241 LKA-IEEALRYSPPVMRTVRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVFHDGEKFI 299 Query: 437 PTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFR 484 P R + +L FG G+ CLG +A LE I + + FR Sbjct: 300 PDRNPNP--------HLSFGSGIHLCLGAPLARLEARIAIEEFSKRFR 339 >5XJN-A nrPDB Length = 455 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 28/108 (25%), Positives = 51/108 (47%), Gaps = 7/108 (6%) Query: 369 TMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTF 428 +L+ L+ A++ E LR V +R + D + I V + + + R+ Sbjct: 317 AILENPKLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEAR 376 Query: 429 FFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFL 476 F + E FD +R +++ +L FG+G+ CLG +A+L+ I L Sbjct: 377 FENGEEFDISRANARE-------HLSFGFGIHYCLGNMLAKLQAKICL 417 >5GWE-A nrPDB Length = 405 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 28/108 (25%), Positives = 51/108 (47%), Gaps = 7/108 (6%) Query: 369 TMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTF 428 +L+ L+ A++ E LR V +R + D + I V + + + R+ Sbjct: 267 AILENPKLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEAR 326 Query: 429 FFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFL 476 F + E FD +R +++ +L FG+G+ CLG +A+L+ I L Sbjct: 327 FENGEEFDISRANARE-------HLSFGFGIHYCLGNMLAKLQAKICL 367 >4PWV-A nrPDB Length = 446 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 30/100 (30%), Positives = 47/100 (47%), Gaps = 8/100 (8%) Query: 377 LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFD 436 L+++ +E LR ++ R V D+ L +I A +V + + R+ F DP FD Sbjct: 303 LESATEEVLRWATPAMHFGRRAVTDMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFD 362 Query: 437 PTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFL 476 R S +K+IT FG+G CLG + E+ L Sbjct: 363 LNR--SPNKHIT------FGYGPHFCLGAYLGRAEVHALL 394 >5EX8-A nrPDB Length = 424 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 39/139 (28%), Positives = 61/139 (43%), Gaps = 22/139 (15%) Query: 381 IKETLR-LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTR 439 + ET+R L T R D+ + + ++ A V ++ A R P + + FD TR Sbjct: 302 LDETMRYLTTDEKTHPRVATQDVRIGNQLVKAGDTVTCSLLAANR-PNYPSAEDEFDITR 360 Query: 440 WLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNL 499 ++ +L FG G+ CLGR +AEL F+V I L+ T L Sbjct: 361 EKAE--------HLAFGHGIHHCLGRAMAEL-----------MFKVSIPALAHRFPTLRL 401 Query: 500 ILMPEKPISFTFWPFNQEA 518 P++ I+ PF+ EA Sbjct: 402 A-DPQREITLGPPPFDVEA 419 >5DE9-A nrPDB Length = 410 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 34/119 (28%), Positives = 58/119 (48%), Gaps = 11/119 (9%) Query: 366 DMATMLQLVPLLKA-SIKETLR--LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYAL 422 ++A L+ P ++ +I E LR H +V L R + D+ ++ I A V V+ A Sbjct: 262 ELAERLRSEPEIRPRAIDELLRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAA 321 Query: 423 GREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLE 481 R+P F DP+ D R S + +++ FG+G C G +A LE + + +L+ Sbjct: 322 NRDPEVFPDPDRIDFER--SPNPHVS------FGFGPHYCPGGMLARLESELLVDAVLD 372 >5Z9I-A nrPDB Length = 398 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 30/114 (26%), Positives = 53/114 (46%), Gaps = 11/114 (9%) Query: 376 LLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENF 435 L+ A ++E++R + R +++ + +IP L+ V A R+ F P+ F Sbjct: 269 LVPALLEESMRYMSPICGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVF 328 Query: 436 DPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTI---FLINMLENFRVE 486 D R + +LGFG G+ CLGR++A +E L++ L R + Sbjct: 329 DAGR--------SPNAHLGFGRGIHFCLGRQLARMESKAAVEILLDRLPTLRAD 374 >4FB2-A nrPDB Length = 398 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 50/239 (20%), Positives = 100/239 (41%), Gaps = 32/239 (13%) Query: 247 MLNLPPDLFRLFRTKTWK-DHVAAWDV---IFSKADIYTQNFYWELRQKGSVHHDYRGIL 302 +L LPP+ +R W HV + IF++ + + E R R I+ Sbjct: 150 LLGLPPEDGDTYRRWVWAITHVENPEEGAEIFAELVAHARTLIAERRTNPGNDIMSRVIM 209 Query: 303 YRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQ 362 ++ G+S +S +D+ T +L GG+D T+ L + +A +++++ L A Sbjct: 210 SKIDGES-LSEDDLIGFFTILLLGGIDNTARFLSSVFWRLAWDIELRRRLIAHP------ 262 Query: 363 AQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYAL 422 +L+P ++ E LR + ++ + R + ++ + D + + Sbjct: 263 ---------ELIP---NAVDELLRFYGPAM-VGRLVTQEVTVGDITMKPGQTAMLWFPIA 309 Query: 423 GREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLE 481 R+ + F P+N R T R+L G G+ +CLG + +E + + L+ Sbjct: 310 SRDRSAFDSPDNIVIER--------TPNRHLSLGHGIHRCLGAHLIRVEARVAITEFLK 360 >5Y1I-A nrPDB Length = 403 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 51/103 (49%), Gaps = 9/103 (8%) Query: 380 SIKETLRLHPISV-TLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFD-PENFDP 437 +++E LR I+ T++R D+ + +I A + + A +P + + P+ D Sbjct: 275 TVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDI 334 Query: 438 TRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML 480 R ++ R+L FG+GV QCLG +A +E+ I +L Sbjct: 335 HRANAR-------RHLAFGYGVHQCLGATLARVELQIVYSTLL 370 >5HH3-A nrPDB Length = 397 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 39/127 (30%), Positives = 54/127 (42%), Gaps = 23/127 (18%) Query: 393 TLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPEN-FDPTRWLSKDKNITYFR 451 T R +D+ + D++I A V ++ A R F PE+ FD TR + Sbjct: 288 THPRVATDDVRIGDHLIKAGDTVTCSLLAANRR--NFPRPEDRFDITRVRPE-------- 337 Query: 452 NLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTF 511 +L FG G+ CLGR +AEL FR I L+ T L P + I Sbjct: 338 HLAFGHGIHHCLGRSLAEL-----------VFRTAIPALAHRFPTLRLA-EPHREIRLGP 385 Query: 512 WPFNQEA 518 PF+ EA Sbjct: 386 PPFDVEA 392 >2WM5-A nrPDB Length = 435 Score = 38.1 bits (87), Expect = 0.010, Method: Compositional matrix adjust. Identities = 29/100 (29%), Positives = 48/100 (48%), Gaps = 9/100 (9%) Query: 376 LLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENF 435 L +++E +R V ++R L D+ LR + A V + + R+ + F DP F Sbjct: 307 LAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTF 366 Query: 436 DPTRWLSKDKNITYFRNLGFGWGVRQ-CLGRRIAELEMTI 474 D L+++ N +LGFG G CLG +A E+ + Sbjct: 367 D----LARNPN----PHLGFGGGGAHFCLGANLARREIRV 398 >2Z36-A nrPDB Length = 413 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 27/96 (28%), Positives = 44/96 (45%), Gaps = 9/96 (9%) Query: 380 SIKETLRLHPISVTL-QRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPT 438 +++E LR I+ + R D+ + I A V V++ + +P F DP D Sbjct: 281 AVEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVE 340 Query: 439 RWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTI 474 R +L FG+G QCLG+ +A +E+ I Sbjct: 341 RGARH--------HLAFGFGPHQCLGQNLARMELQI 368 >5D3U-A nrPDB Length = 427 Score = 36.2 bits (82), Expect = 0.033, Method: Compositional matrix adjust. Identities = 26/104 (25%), Positives = 44/104 (42%), Gaps = 7/104 (6%) Query: 380 SIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTR 439 + E LR + + R D+ + I A + + + + R+ F P +FD R Sbjct: 303 TANEVLRYNASNQFTWRVAAKDVEMGGVRIEAGQTLALFLGSANRDANMFERPNDFDLDR 362 Query: 440 WLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 S R+L FG GV CL ++ L++ F + +L F Sbjct: 363 PNSA-------RHLSFGQGVHACLAAQLISLQLKWFYVALLNRF 399 >5H1Z-A nrPDB Length = 407 Score = 36.2 bits (82), Expect = 0.034, Method: Compositional matrix adjust. Identities = 39/171 (22%), Positives = 74/171 (43%), Gaps = 25/171 (14%) Query: 309 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMA 368 ++M + N+ ++ GG DTT T+ Y + D+ + R + + D + Sbjct: 228 AEMDQMEFLGNLILLIVGGNDTTRNTMSAVAYGL-------DLFPDQ----RAKLEADPS 276 Query: 369 TMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTF 428 ++ +++E +R ++R D L I A + + + R+ + Sbjct: 277 -------MIPNTVQEIIRWQTPLAHMRRTATVDSELEGQQIKAGDKLALWYISANRDESV 329 Query: 429 FFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINM 479 F EN D R + N R+L FG G+ +C+G R+AEL++ + L M Sbjct: 330 F---ENAD--RIIVDRPNAR--RHLAFGHGIHRCVGARLAELQIAVLLEEM 373 >2IAG-A nrPDB Length = 482 Score = 36.2 bits (82), Expect = 0.041, Method: Compositional matrix adjust. Identities = 41/174 (23%), Positives = 76/174 (43%), Gaps = 24/174 (13%) Query: 337 WHLYEMARNLKVQDMLRAEVLAARHQAQGDMA-------TMLQLVPLLKASIKETLRLHP 389 W L + +N + +R E+ + QA+ ++ +L P+L + + E+LRL Sbjct: 272 WLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-T 330 Query: 390 ISVTLQRYLVNDLVL-----RDYMIP-AKTLVQVAIYALGREPTFFFDPENFDPTRWLSK 443 + + R +V DL + R++ + L+ + R+P + DPE F R+L+ Sbjct: 331 AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNP 390 Query: 444 D--------KNITYFRNLGFGWGV--RQCLGRRIAELEMTIFLINMLENFRVEI 487 D K+ +N WG CLGR A + F+ +L + +E+ Sbjct: 391 DGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLEL 444 >6DCD-A nrPDB Length = 424 Score = 35.0 bits (79), Expect = 0.084, Method: Compositional matrix adjust. Identities = 40/167 (23%), Positives = 64/167 (38%), Gaps = 25/167 (14%) Query: 315 DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLV 374 D+ + T + A G +TT+ L + VL R Q + L+ Sbjct: 241 DVVRSATFLFAAGQETTAKLLTAAM---------------RVLGDRPDIQRRLRENRSLI 285 Query: 375 PLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPEN 434 P I+E+LR+ + R + I A T+V V A R+P F DP Sbjct: 286 PNF---IEESLRMDSPVKSDSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHE 342 Query: 435 FDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLE 481 F R ++ ++ F GV C G +A +E + L +L+ Sbjct: 343 FRLDRPNVRE-------HMAFARGVHSCPGGPLARVEGRVSLERILD 382 >3BUJ-A nrPDB Length = 397 Score = 34.7 bits (78), Expect = 0.093, Method: Compositional matrix adjust. Identities = 32/110 (29%), Positives = 52/110 (47%), Gaps = 9/110 (8%) Query: 363 AQGDMATMLQLVP-LLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYA 421 A D +L+ P LL +++E LR P + R L D+ LR + +V V A Sbjct: 251 AHPDQLDLLRRRPDLLAQAVEECLRYDPSVQSNTRQLDVDVELRGRRLRRDDVVVVLAGA 310 Query: 422 LGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELE 471 R+P + P++FD + +D ++ FG G+R CLG +A + Sbjct: 311 ANRDPRRYDRPDDFD----IERDP----VPSMSFGAGMRYCLGSYLARTQ 352 >6CVC-A nrPDB Length = 433 Score = 34.7 bits (78), Expect = 0.10, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 44/100 (44%), Gaps = 9/100 (9%) Query: 376 LLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENF 435 L +++E +R V ++R L D+ LR + A V + + R+ F DP F Sbjct: 304 LAATAVEEIVRWASPVVYMRRTLSQDVDLRGTKMAAGDKVTLWYCSANRDEEKFADPWTF 363 Query: 436 DPTRWLSKDKNITYFRNLGFGWGVRQ-CLGRRIAELEMTI 474 D TR + +GFG G CLG +A E+ + Sbjct: 364 DVTRNPNP--------QVGFGGGGAHFCLGANLARREIRV 395 >5HIW-A nrPDB Length = 398 Score = 34.3 bits (77), Expect = 0.15, Method: Compositional matrix adjust. Identities = 27/117 (23%), Positives = 52/117 (44%), Gaps = 8/117 (6%) Query: 367 MATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREP 426 M + Q LL +I+E+ R + + R++ + + + A T++ +++ A + Sbjct: 251 MNQLRQQPSLLPQAIEESTRWCSSAAGIVRFVEREATIGGETLAAGTILYLSLIARHYDE 310 Query: 427 TFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 + PE FD R L FG G+ C+G +A +E + + +LE F Sbjct: 311 EIYPRPETFDIHRR--------PVGMLNFGGGLHYCVGAPLARMEARVGVSLLLERF 359 >5YHJ-A nrPDB Length = 413 Score = 33.5 bits (75), Expect = 0.20, Method: Compositional matrix adjust. Identities = 32/130 (24%), Positives = 56/130 (43%), Gaps = 5/130 (3%) Query: 381 IKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRW 440 ++E R +P + D Y P TL + +Y + + + +P+ FDP+R+ Sbjct: 276 VQEVRRFYPFFPVAAARVKTDFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSRF 335 Query: 441 LSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTI-FLINMLENFRVEIQH-LSDVGTTFN 498 KD + F + G G G R A +TI L ++E F E + + +++ Sbjct: 336 --KDWKESPFNFIPQGGGDVD-FGHRCAGEHVTIAILAQVIELFTKEYAYTVPPQDLSYS 392 Query: 499 LILMPEKPIS 508 + MP P S Sbjct: 393 FVDMPSLPKS 402 >1LG9-A nrPDB Length = 398 Score = 33.5 bits (75), Expect = 0.22, Method: Compositional matrix adjust. Identities = 24/88 (27%), Positives = 33/88 (37%), Gaps = 8/88 (9%) Query: 396 RYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGF 455 R DL L I V ++ A R+P D + D TR ++ F Sbjct: 289 RIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTR--------EPIPHVAF 340 Query: 456 GWGVRQCLGRRIAELEMTIFLINMLENF 483 G GV CLG +A LE+ + F Sbjct: 341 GHGVHHCLGAALARLELRTVFTELWRRF 368 >2X9P-A nrPDB Length = 404 Score = 33.5 bits (75), Expect = 0.24, Method: Compositional matrix adjust. Identities = 45/141 (31%), Positives = 60/141 (42%), Gaps = 23/141 (16%) Query: 356 VLAARHQAQGDMATMLQLVPLLKASIKETLRLHPI--SVTLQRYLVNDLVLRDYMIPAKT 413 VL A H Q A L ++ +++E LR SV RY D+ I A Sbjct: 255 VLLAAHPDQ--RAAALADPDVMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGD 312 Query: 414 LVQVAIYALGREPTF----FFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAE 469 LV ++ LG P F F PE FD R T +L FG G+ C+G +A Sbjct: 313 LV---LFDLGL-PNFDERAFTGPEEFDAAR--------TPNPHLTFGHGIWHCIGAPLAR 360 Query: 470 LEM-TIF--LINMLENFRVEI 487 LE+ T+F L L R E+ Sbjct: 361 LELRTMFTKLFTRLPELRPEL 381 >6FSH-A nrPDB Length = 398 Score = 33.1 bits (74), Expect = 0.32, Method: Compositional matrix adjust. Identities = 21/88 (23%), Positives = 36/88 (40%), Gaps = 8/88 (9%) Query: 396 RYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGF 455 R V D+++ D +I V ++ R+ D + D TR T ++ F Sbjct: 289 RTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR--------TPVPHVAF 340 Query: 456 GWGVRQCLGRRIAELEMTIFLINMLENF 483 G G+ CLG + L++ I + F Sbjct: 341 GHGIHHCLGAALTRLQLRIAYTALWRRF 368 >4C9K-A nrPDB Length = 421 Score = 33.1 bits (74), Expect = 0.32, Method: Compositional matrix adjust. Identities = 33/133 (24%), Positives = 57/133 (42%), Gaps = 17/133 (12%) Query: 377 LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFD 436 L+ ++E R + V+ RY+V+D+ M+ L+ + G + DP D Sbjct: 289 LQRGVEELFRRFAV-VSDARYVVSDMEFHGTMLKEGDLILLPTALHGLDDRHHDDPMTVD 347 Query: 437 PTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFL---INMLENFR-----VEIQ 488 +R +++T+ F G +C G +A LE+T+ L + + FR V I Sbjct: 348 LSR-----RDVTHST---FAQGPHRCAGMHLARLEVTVMLQEWLARIPEFRLKDRAVPIY 399 Query: 489 HLSDVGTTFNLIL 501 H V N+ L Sbjct: 400 HSGIVAAVENIPL 412 >4TX3-A nrPDB Length = 404 Score = 32.7 bits (73), Expect = 0.40, Method: Compositional matrix adjust. Identities = 21/88 (23%), Positives = 36/88 (40%), Gaps = 8/88 (9%) Query: 396 RYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGF 455 R V D+++ D +I V ++ R+ D + D TR T ++ F Sbjct: 295 RTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR--------TPVPHVAF 346 Query: 456 GWGVRQCLGRRIAELEMTIFLINMLENF 483 G G+ CLG + L++ I + F Sbjct: 347 GHGIHHCLGAALTRLQLRIAYTALWRRF 374 >3OO3-A nrPDB Length = 384 Score = 32.3 bits (72), Expect = 0.49, Method: Compositional matrix adjust. Identities = 26/118 (22%), Positives = 53/118 (44%), Gaps = 14/118 (11%) Query: 367 MATMLQLVPLLKASIKETLRLHPI-SVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGRE 425 MA + + L+ ++ +E LR I R + D+ + I A ++ ++ A R Sbjct: 249 MALLREKPELIDSATEEVLRHASIVEAPAPRVALADVRMAGRDIHAGDVLTCSMLATNRA 308 Query: 426 PTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 P FD ++++K ++ FG G+ C+G +A L++ + L ++ F Sbjct: 309 PGDRFD---------ITREKAT----HMAFGHGIHHCIGAPLARLQLRVALPAVVGRF 353 >6M7L-A nrPDB Length = 404 Score = 32.0 bits (71), Expect = 0.74, Method: Compositional matrix adjust. Identities = 18/55 (32%), Positives = 27/55 (49%), Gaps = 10/55 (18%) Query: 431 DP--ENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 DP + FD TR S R++ FG G+ CLG +A +E+ I ++ F Sbjct: 327 DPALDGFDITRKES--------RHVAFGHGIHHCLGAPLARMELRIAFTTLVSRF 373 >4XE3-A nrPDB Length = 407 Score = 31.6 bits (70), Expect = 0.89, Method: Compositional matrix adjust. Identities = 24/110 (21%), Positives = 47/110 (42%), Gaps = 10/110 (9%) Query: 376 LLKASIKETLRLHPI--SVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPE 433 L+ A+++E LR P+ + + R D+ L + A V + R+ F + Sbjct: 276 LVPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASANRDEEVFDHAD 335 Query: 434 NFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 D +++N ++ FG G C+G ++ LE+ L ++ F Sbjct: 336 ELD----FHRERN----PHIAFGHGAHHCIGAQLGRLELQEALSALVRRF 377 >5CLR-A nrPDB Length = 451 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 15/38 (39%), Positives = 21/38 (55%), Gaps = 1/38 (2%) Query: 60 LNLYHFWRETGTHKVHLHHVQNFQKYGPIYRE-KLGNV 96 +NL HFW G H V+ F + G I+R+ K GN+ Sbjct: 170 VNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNI 207 >2YJN-B nrPDB Length = 381 Score = 30.4 bits (67), Expect = 2.2, Method: Compositional matrix adjust. Identities = 20/73 (27%), Positives = 35/73 (47%), Gaps = 1/73 (1%) Query: 380 SIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTR 439 ++ E LRLHP +R ++ L +++I V V + A R+P F +P+ D R Sbjct: 258 TVAEVLRLHPALHLERRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVDR 317 Query: 440 WLSKDKNITYFRN 452 D+ ++ R Sbjct: 318 -PDADRALSAHRG 329 >2X44-D nrPDB Length = 131 Score = 30.0 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 15/40 (37%), Positives = 20/40 (50%), Gaps = 10/40 (25%) Query: 85 YGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIP 124 Y P Y +GN +YVIDPE P+P+ L+P Sbjct: 101 YPPPYYLGIGNGTQIYVIDPE----------PSPDSDLVP 130 >6G5O-A nrPDB Length = 399 Score = 29.6 bits (65), Expect = 3.6, Method: Compositional matrix adjust. Identities = 30/167 (17%), Positives = 64/167 (38%), Gaps = 26/167 (15%) Query: 310 KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMAT 369 K++ E++K + AGG DT + + +A + + + LR E Sbjct: 204 KLTKEEVKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRKE-------------- 249 Query: 370 MLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFF 429 + +++E +R + R + D + ++ + A + + + + R+ F Sbjct: 250 ----PEITGRAVEEMIRYFSPLTQMGRVVTEDTHVCEHAVKADSRISLCWASANRDAAVF 305 Query: 430 FDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFL 476 +P R ++ ++GFG+ CLG A + I L Sbjct: 306 ENPNEIVLDRKVNP--------HVGFGFSHHNCLGATHARQILKILL 344 >3MPG-A nrPDB Length = 428 Score = 28.9 bits (63), Expect = 5.1, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 19/36 (52%) Query: 433 ENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIA 468 E DPT +LSK KN + GW V +G +IA Sbjct: 385 EEIDPTTFLSKGKNTPFAGWKCQGWPVMTIVGGKIA 420 >1KA4-A nrPDB Length = 499 Score = 28.9 bits (63), Expect = 5.2, Method: Compositional matrix adjust. Identities = 24/93 (25%), Positives = 43/93 (46%), Gaps = 12/93 (12%) Query: 204 RFAFESITNVI---FGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLN--LPPDLFRLF 258 RF F I + E Q E + ++ F++ IY + ++P ++ P D++ F Sbjct: 283 RFMFTPIAGGVSLGIHESQSRFWENIIGRSKEFVELIYPVLKENLPFMSNYTPEDVYLYF 342 Query: 259 RTKTWKDHVAAWDVIFSKADIYTQNFYWELRQK 291 ++ D I ++AD+ T NF+ LR K Sbjct: 343 -------NIVRPDFIRTEADVVTYNFHILLRFK 368 >3AWQ-A nrPDB Length = 415 Score = 28.9 bits (63), Expect = 5.2, Method: Compositional matrix adjust. Identities = 41/218 (18%), Positives = 78/218 (35%), Gaps = 24/218 (11%) Query: 309 SKMSFEDIKANVTEMLAGGVDTTSMTLQWH-------LYEMARNLKVQDMLRAEVLAARH 361 +K E I+A + G T + + WH L +++ ++LR V A + Sbjct: 193 AKRIIEGIRAG---SIGSGSGTAAYAIAWHRDRHDDLLSPHVAAVELVNVLRPTVAIAVY 249 Query: 362 ---------QAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAK 412 G A ++Q + ++E R +P + D P Sbjct: 250 ITFVAHALQTCSGIRAALVQQPDYAELFVQEVRRFYPFFPAVVARASQDFEWEGMAFPEG 309 Query: 413 TLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFG--WGVRQCLGRRIAEL 470 V + +Y + + DP+ F P R+ + D++ F G G + +C G I Sbjct: 310 RQVVLDLYGSNHDAATWADPQEFRPERFRAWDEDSFNFIPQGGGDHYLGHRCPGEWIVLA 369 Query: 471 EMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPIS 508 M + ++ R ++ D + + +P P S Sbjct: 370 IMKVAAHLLVNAMRYDV---PDQDLSIDFARLPALPKS 404 >3TB2-A nrPDB Length = 220 Score = 28.5 bits (62), Expect = 7.1, Method: Compositional matrix adjust. Identities = 18/56 (32%), Positives = 30/56 (53%), Gaps = 7/56 (12%) Query: 269 AWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLG---DSKMS----FEDIK 317 +W ++FS + +T EL + G +H D+ + +L+G +SK S EDIK Sbjct: 32 SWAILFSHPNDFTPVCTTELAELGKMHEDFLKLNCKLIGFSCNSKESHDKWIEDIK 87 >4KVO-A nrPDB Length = 731 Score = 28.5 bits (62), Expect = 7.7, Method: Compositional matrix adjust. Identities = 15/85 (17%), Positives = 43/85 (50%), Gaps = 7/85 (8%) Query: 299 RGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLA 358 +GIL LG++K +++++ + + GV WH++ + + A+ Sbjct: 50 KGILLHSLGNTKEGYDNVRLGLRNDVGSGV-------CWHIFGLISRADKDYVQAAKCYI 102 Query: 359 ARHQAQGDMATMLQLVPLLKASIKE 383 H+ + + +++L+ + LL++ +++ Sbjct: 103 NAHKLEKNNSSLLRDLALLQSQLRQ 127 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3N9Z-A nrPDB 627 e-180 3MZS-A nrPDB 579 e-165 4ZGX-A nrPDB 480 e-136 6M7X-A nrPDB 473 e-134 3K9V-A nrPDB 435 e-122 5VEU-A nrPDB 335 2e-92 5YLW-A nrPDB 328 3e-90 2VE3-A nrPDB 325 3e-89 3QZ1-A nrPDB 322 3e-88 3MDV-A nrPDB 319 2e-87 6C94-A nrPDB 315 2e-86 6DA2-A nrPDB 313 1e-85 5VBU-A nrPDB 310 6e-85 2WX2-A nrPDB 303 2e-82 3L4D-A nrPDB 300 9e-82 2X2N-A nrPDB 283 2e-76 6B82-A nrPDB 273 1e-73 4R20-A nrPDB 264 6e-71 3DL9-A nrPDB 261 5e-70 4R1Z-A nrPDB 256 2e-68 5W0C-A nrPDB 250 1e-66 1N6B-A nrPDB 250 2e-66 2NNH-A nrPDB 249 2e-66 3IBD-A nrPDB 247 1e-65 5E0E-A nrPDB 246 2e-65 4GQS-A nrPDB 245 3e-65 5E58-A nrPDB 245 3e-65 4H1N-A nrPDB 245 4e-65 2HI4-A nrPDB 242 3e-64 5UYS-A nrPDB 240 8e-64 3E6I-A nrPDB 239 3e-63 6DWN-A nrPDB 238 4e-63 2PG7-A nrPDB 237 7e-63 3JUS-A nrPDB 235 5e-62 6AYB-A nrPDB 228 3e-60 6IQ5-A nrPDB 228 4e-60 3EL3-A nrPDB 225 3e-59 3TBG-A nrPDB 225 5e-59 4WMZ-A nrPDB 221 6e-58 5FSA-A nrPDB 220 9e-58 5JLC-A nrPDB 220 2e-57 2W0A-A nrPDB 215 4e-56 3EJB-B nrPDB 200 1e-51 5VWS-A nrPDB 200 1e-51 6CR2-A nrPDB 198 4e-51 3S79-A nrPDB 197 8e-51 4RM4-A nrPDB 193 1e-49 5L94-A nrPDB 191 4e-49 3RWL-A nrPDB 191 5e-49 4JBT-A nrPDB 191 7e-49 5OFQ-A nrPDB 191 7e-49 1UED-A nrPDB 188 4e-48 2ZBZ-A nrPDB 187 8e-48 4Z5P-A nrPDB 187 1e-47 4GGV-A nrPDB 184 6e-47 6HQW-A nrPDB 180 1e-45 4UBS-A nrPDB 180 1e-45 5EX6-C nrPDB 179 2e-45 5CJE-A nrPDB 179 2e-45 2VZM-A nrPDB 179 2e-45 3R9C-A nrPDB 179 2e-45 5XW2-A nrPDB 179 3e-45 2XKR-A nrPDB 178 4e-45 4TRI-A nrPDB 178 6e-45 6B11-A nrPDB 177 8e-45 1CPT-A nrPDB 177 8e-45 4YZR-A nrPDB 177 9e-45 6GMF-A nrPDB 176 2e-44 1Z8P-A nrPDB 176 3e-44 2FR7-A nrPDB 175 5e-44 6A7J-A nrPDB 174 6e-44 6HQG-A nrPDB 174 6e-44 6GK6-A nrPDB 173 2e-43 5LIE-A nrPDB 173 2e-43 2Y5N-A nrPDB 173 2e-43 3MGX-A nrPDB 173 2e-43 1ODO-A nrPDB 172 4e-43 3ABB-A nrPDB 171 5e-43 3WVS-A nrPDB 171 6e-43 4WPZ-A nrPDB 171 8e-43 1Q5D-A nrPDB 170 1e-42 5YSW-A nrPDB 170 1e-42 6A7I-A nrPDB 169 2e-42 4DO1-A nrPDB 169 4e-42 4OQS-A nrPDB 168 6e-42 5FOI-A nrPDB 166 2e-41 4MM0-A nrPDB 166 2e-41 5FYF-A nrPDB 166 2e-41 3A50-A nrPDB 166 2e-41 1EHE-A nrPDB 165 4e-41 2WIO-A nrPDB 165 4e-41 3A1L-A nrPDB 165 4e-41 4OQR-A nrPDB 165 5e-41 3TYW-A nrPDB 164 7e-41 3P3Z-A nrPDB 163 1e-40 5NWS-A nrPDB 163 2e-40 3NC3-A nrPDB 162 3e-40 5IT1-A nrPDB 162 5e-40 6HQD-A nrPDB 160 1e-39 1UE8-A nrPDB 160 1e-39 3ABA-A nrPDB 158 5e-39 3TKT-A nrPDB 158 6e-39 5HDI-A nrPDB 158 7e-39 3SN5-A nrPDB 157 1e-38 2RFC-A nrPDB 157 1e-38 6F0B-A nrPDB 156 2e-38 3OFT-A nrPDB 154 6e-38 1GWI-A nrPDB 152 5e-37 5L1U-A nrPDB 147 1e-35 6GII-A nrPDB 143 2e-34 2WIY-A nrPDB 136 2e-32 2NZA-A nrPDB 135 5e-32 1WIY-A nrPDB 134 1e-31 6G71-A nrPDB 133 2e-31 Sequences not found previously or not previously below threshold: 4KPA-A nrPDB 191 7e-49 5XJN-A nrPDB 178 5e-45 5GWE-A nrPDB 178 5e-45 4YT3-A nrPDB 171 5e-43 5XNT-A nrPDB 171 6e-43 4TX3-A nrPDB 167 1e-41 2Z36-A nrPDB 166 3e-41 5Y1I-A nrPDB 165 4e-41 1LG9-A nrPDB 164 6e-41 6FSH-A nrPDB 163 2e-40 5LIV-A nrPDB 160 1e-39 4XE3-A nrPDB 160 2e-39 6F88-A nrPDB 159 2e-39 5H1Z-A nrPDB 159 4e-39 2WM5-A nrPDB 157 1e-38 6M7L-A nrPDB 156 3e-38 1F4U-A nrPDB 155 4e-38 5Z9I-A nrPDB 155 4e-38 6DCD-A nrPDB 154 9e-38 5DQN-A nrPDB 153 1e-37 4PWV-A nrPDB 150 1e-36 5DE9-A nrPDB 148 5e-36 6CVC-A nrPDB 148 6e-36 4Z5Q-A nrPDB 146 3e-35 5HIW-A nrPDB 145 4e-35 3IVY-A nrPDB 142 2e-34 6G5O-A nrPDB 140 1e-33 2X9P-A nrPDB 140 2e-33 2UUQ-A nrPDB 137 9e-33 3WEC-A nrPDB 137 1e-32 3OO3-A nrPDB 136 3e-32 5HH3-A nrPDB 131 6e-31 6BLD-A nrPDB 127 1e-29 3BUJ-A nrPDB 126 2e-29 4FB2-A nrPDB 125 4e-29 5EX8-A nrPDB 125 4e-29 2IJ7-A nrPDB 123 2e-28 5KYO-A nrPDB 116 3e-26 5D3U-A nrPDB 112 3e-25 2IAG-A nrPDB 109 3e-24 6FYJ-A nrPDB 109 4e-24 2QBO-A nrPDB 108 5e-24 2ZQJ-A nrPDB 104 7e-23 5YHJ-A nrPDB 104 9e-23 5OMS-A nrPDB 103 1e-22 3NV6-A nrPDB 99 5e-21 2RCM-A nrPDB 97 2e-20 4C9K-A nrPDB 96 3e-20 5M0P-A nrPDB 94 9e-20 3B98-A nrPDB 89 5e-18 3AWQ-A nrPDB 87 2e-17 3DBM-A nrPDB 87 2e-17 2YJN-B nrPDB 71 2e-12 5XF8-3 nrPDB 34 0.11 4YXC-B nrPDB 33 0.38 3RFT-A nrPDB 31 0.94 2B8N-A nrPDB 31 1.2 3G6B-A nrPDB 31 1.2 6F73-A nrPDB 31 1.7 4YXB-D nrPDB 31 2.1 1H4I-A nrPDB 30 2.4 1R6B-X nrPDB 30 3.5 5NL1-A nrPDB 29 4.1 1SJ8-A nrPDB 29 4.1 1SJ7-A nrPDB 29 4.1 1V02-A nrPDB 29 4.5 4ZMU-A nrPDB 29 6.3 6MDR-a nrPDB 29 7.0 2D0V-A nrPDB 28 8.6 2C4R-L nrPDB 28 9.6 >3N9Z-A nrPDB Length = 487 Score = 627 bits (1616), Expect = e-180, Method: Composition-based stats. Identities = 481/481 (100%), Positives = 481/481 (100%) Query: 41 STRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVY 100 STRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVY Sbjct: 1 STRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVY 60 Query: 101 VIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMA 160 VIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMA Sbjct: 61 VIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMA 120 Query: 161 PEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQG 220 PEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQG Sbjct: 121 PEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQG 180 Query: 221 MLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIY 280 MLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIY Sbjct: 181 MLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIY 240 Query: 281 TQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLY 340 TQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLY Sbjct: 241 TQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLY 300 Query: 341 EMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVN 400 EMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVN Sbjct: 301 EMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVN 360 Query: 401 DLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVR 460 DLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVR Sbjct: 361 DLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVR 420 Query: 461 QCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQ 520 QCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQ Sbjct: 421 QCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQ 480 Query: 521 Q 521 Q Sbjct: 481 Q 481 >3MZS-A nrPDB Length = 486 Score = 579 bits (1491), Expect = e-165, Method: Composition-based stats. Identities = 353/480 (73%), Positives = 418/480 (87%), Gaps = 1/480 (0%) Query: 41 STRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVY 100 ST++PRP++EIPSPGDNGWLNLYHFWRE G+ ++H H++NFQKYGPIYREKLGN+ESVY Sbjct: 3 STKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVY 62 Query: 101 VIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMA 160 +I PEDVA LFK EG PER+ IPPW+AYH+YYQ+PIGVL KKS WKKDRV LN EVMA Sbjct: 63 IIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMA 122 Query: 161 PEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQG 220 PEA KNF+PLL+ VS+DFVS+LH+RIK+ GSG + GDI +DLF FAFESITNV+FGER G Sbjct: 123 PEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLG 182 Query: 221 MLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIY 280 MLEE VNPEAQ+FIDA+Y+MFHTSVP+LN+PP+L+RLFRTKTW+DHVAAWD IF+KA+ Y Sbjct: 183 MLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKY 242 Query: 281 TQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLY 340 T+ FY +LR+K +Y GILY LL KM ED+KAN+TEMLAGGV+TTSMTLQWHLY Sbjct: 243 TEIFYQDLRRKTEF-RNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLY 301 Query: 341 EMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVN 400 EMAR+L VQ+MLR EVL AR QA+GD++ MLQ+VPLLKASIKETLRLHPISVTLQRY + Sbjct: 302 EMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPES 361 Query: 401 DLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVR 460 DLVL+DY+IPAKTLVQVAIYA+GR+P FF P+ FDPTRWLSKDK++ +FRNLGFGWGVR Sbjct: 362 DLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVR 421 Query: 461 QCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQ 520 QC+GRRIAELEMT+FLI++LENF+VE+QH+ DV T FNLIL P+KPI F PFNQ+ Q Sbjct: 422 QCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQDPPQ 481 >4ZGX-A nrPDB Length = 489 Score = 480 bits (1235), Expect = e-136, Method: Composition-based stats. Identities = 189/481 (39%), Positives = 275/481 (57%), Gaps = 5/481 (1%) Query: 38 AGISTRSPR---PFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLG 94 A + R+PR PF +P N WL L WRE G +HL Q FQ+ GPI+R LG Sbjct: 2 ATKAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLG 61 Query: 95 NVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVAL 154 V V+ PEDV L + + +P R ++ PWVAY Q+ GV L W+ +R+ L Sbjct: 62 GPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRL 121 Query: 155 NQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVI 214 N +V++P+A + FLP++DAV+RDF L +++ + G+ + D+ +F + E+ + Sbjct: 122 NPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL 181 Query: 215 FGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIF 274 FGER G++ + + F+ A+ MF ++V ++ +P L R K WK+H AWD IF Sbjct: 182 FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIF 241 Query: 275 SKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMT 334 D Q Y EL H Y GI+ LL +++S E IKAN E+ AG VDTT+ Sbjct: 242 QYGDNCIQKIYQELAFNRPQH--YTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFP 299 Query: 335 LQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTL 394 L L+E+ARN VQ +LR E LAA +PLL+A++KETLRL+P+ + L Sbjct: 300 LLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 359 Query: 395 QRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLG 454 +R + +DLVL++Y IPA TLVQV +Y+LGR F PE ++P RWL + F ++ Sbjct: 360 ERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVP 419 Query: 455 FGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPF 514 FG+G+RQCLGRR+AE EM + L ++L++F VE D+ ++ IL P TF Sbjct: 420 FGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAI 479 Query: 515 N 515 N Sbjct: 480 N 480 >6M7X-A nrPDB Length = 484 Score = 473 bits (1217), Expect = e-134, Method: Composition-based stats. Identities = 183/474 (38%), Positives = 266/474 (56%), Gaps = 2/474 (0%) Query: 43 RSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVI 102 R+ PF +P N WL L WRE G +HL Q FQ+ GPI+R LG V V+ Sbjct: 10 RTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVM 69 Query: 103 DPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPE 162 PEDV L + + +P R + PWVAY Q+ GV L W+ +R+ LN EV++P Sbjct: 70 LPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPN 129 Query: 163 ATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGML 222 A + FLP++DAV+RDF L +++ + G+ + D+ +F + E+ +FGER G++ Sbjct: 130 AVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLV 189 Query: 223 EEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQ 282 + + F+ A+ MF ++V ++ +P L R K WK+H AWD IF D Q Sbjct: 190 GHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQ 249 Query: 283 NFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEM 342 Y EL Y I+ LL ++++S + IKAN E+ AG VDTT L L+E+ Sbjct: 250 KIYQELAFSRPQQ--YTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFEL 307 Query: 343 ARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDL 402 ARN VQ LR E LAA +PLL+A++KETLRL+P+ + L+R +DL Sbjct: 308 ARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDL 367 Query: 403 VLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQC 462 VL++Y IPA TLV+V +Y+LGR P F PE ++P RWL + F ++ FG+G+RQC Sbjct: 368 VLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQC 427 Query: 463 LGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQ 516 LGRR+AE EM + L ++L++ +VE D+ ++ IL P TF N Sbjct: 428 LGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAINH 481 >3K9V-A nrPDB Length = 482 Score = 435 bits (1118), Expect = e-122, Method: Composition-based stats. Identities = 143/471 (30%), Positives = 231/471 (49%), Gaps = 11/471 (2%) Query: 46 RPFNEIPSPGDNGWLN--LYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVID 103 R ++P P + L L FW+ G K H + +KYG I+R KLG+ +SV++ Sbjct: 21 RNVTDLPGPTNWPLLGSLLEIFWK-GGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGS 79 Query: 104 PEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEA 163 P + L+++E +P+R I PW AY + G+++ + W++ R A +++M P Sbjct: 80 PSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVE 139 Query: 164 TKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLE 223 ++ V DF+ + + G D+ +L +++FESI V++ +R G+L+ Sbjct: 140 IMKLDKKINEVLADFLERMDELCDERGR---IPDLYSELNKWSFESICLVLYEKRFGLLQ 196 Query: 224 EVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQN 283 + EA FI AI M T M+ P +L + TK W+ H AWD IF N Sbjct: 197 KETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDN 256 Query: 284 FYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMA 343 Q+ D+ +Y+ +S +++ A VTE+ V+TT+ +L W LY ++ Sbjct: 257 RLQRYSQQPGA--DFLCDIYQ---QDHLSKKELYAAVTELQLAAVETTANSLMWILYNLS 311 Query: 344 RNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLV 403 RN + Q L EV + Q A L+ +P LKA +KE++RL P R L V Sbjct: 312 RNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTV 371 Query: 404 LRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCL 463 L +Y +P T++ + LG F D F P RWL K+K I F +L FG G R C+ Sbjct: 372 LGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCI 431 Query: 464 GRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPF 514 GRR+AEL++ + L +++ + + V IL+P + + F P Sbjct: 432 GRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRPR 482 >5VEU-A nrPDB Length = 480 Score = 335 bits (860), Expect = 2e-92, Method: Composition-based stats. Identities = 108/483 (22%), Positives = 193/483 (39%), Gaps = 54/483 (11%) Query: 51 IPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALL 110 IP P L +R+ + + ++KYG ++ G + + + DP+ + + Sbjct: 17 IPGPTPLPLLGNVLSYRQG----LWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTV 72 Query: 111 FKSEGPNPERFLIPPWVAYHQYYQR----PIGVL-----LKKSAAWKKDRVALNQEVMAP 161 E Y + R P+G + L + WK+ R +++P Sbjct: 73 LVKE-------------CYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIR-----SLLSP 114 Query: 162 EATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGM 221 T L + + + VL R +++ + D ++ + IT FG Sbjct: 115 TFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVN--- 171 Query: 222 LEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYT 281 ++ + NP+ F+++ + L P + A +V D Sbjct: 172 IDSLNNPQ-DPFVESTKKFLKFGF----LDPLFLSIILFPFLTPVFEALNVSLFPKDTIN 226 Query: 282 QNFYWELRQKGSVHHD---YRGILYRLLGDSKMSFE----------DIKANVTEMLAGGV 328 R K S +D +R +L+ DS+ S E ++ A + G Sbjct: 227 FLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGY 286 Query: 329 DTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLH 388 +TTS L + LYE+A + VQ L+ E+ A + + L + ETLRL Sbjct: 287 ETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLF 346 Query: 389 PISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNIT 448 P+++ L+R D+ + IP ++V + YAL +P ++ +PE F P R+ K +I Sbjct: 347 PVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID 406 Query: 449 YFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNL--ILMPEKP 506 + FG G R C+G R A + M + LI +L+NF + + + + +L PEKP Sbjct: 407 PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKP 466 Query: 507 ISF 509 I Sbjct: 467 IVL 469 >5YLW-A nrPDB Length = 495 Score = 328 bits (841), Expect = 3e-90, Method: Composition-based stats. Identities = 100/490 (20%), Positives = 196/490 (40%), Gaps = 29/490 (5%) Query: 37 GAGISTRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNV 96 A I+ S R +P PG + + + + H + ++YGP+ LG++ Sbjct: 14 AATITFLSFRRRRNLP-PGPFPYPIVGNMLQLGA--NPHQVFAKLSKRYGPLMSIHLGSL 70 Query: 97 ESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQ 156 +V V PE + G I V + + +G L ++ W+ R + Sbjct: 71 YTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDKISMG-FLPVASEWRDMRKICKE 129 Query: 157 EVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFG 216 ++ + ++ + + R + L ++K + DI + F ++ +F Sbjct: 130 QMFSNQSMEAS----QGLRRQKLQQLLDHVQKCSDSGRAVDIREAAFITTLNLMSATLFS 185 Query: 217 ERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSK 276 + + E + I+ + + VP D F + R + DV F K Sbjct: 186 SQATEFDSKATMEFKEIIEGVATI--VGVPNF---ADYFPILRPFDPQGVKRRADVFFGK 240 Query: 277 ADIYTQNFYWELRQKGSVH------HDYRGILYRLL--GDSKMSFEDIKANVTEMLAGGV 328 + + E + + D+ I+ ++ + K+ + ++ GG Sbjct: 241 LLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQANEFKLKTHHFTHLMLDLFVGGS 300 Query: 329 DTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLH 388 DT + +++W + E+ N L+AE+ + + + + +P L+A IKE +R+H Sbjct: 301 DTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDESAMPKLPYLQAVIKEVMRIH 360 Query: 389 PI-SVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSK--DK 445 P + L R +D + Y+IP T + + YA+GR+P+ + DPE FDP R+L D Sbjct: 361 PPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSIWTDPETFDPERFLDNKIDF 420 Query: 446 NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSD-----VGTTFNLI 500 + L FG G R C G +A + + ++ NF +++ S G F + Sbjct: 421 KGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNFDWKLEDDSTAAADHAGELFGVA 480 Query: 501 LMPEKPISFT 510 + P+ Sbjct: 481 VRRAVPLRII 490 >2VE3-A nrPDB Length = 444 Score = 325 bits (832), Expect = 3e-89, Method: Composition-based stats. Identities = 100/477 (20%), Positives = 180/477 (37%), Gaps = 49/477 (10%) Query: 44 SPRPFNEIP-SPGDNG--WLN-LYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESV 99 SP N +P PGD G WL +F + K + Q++GPI++ +L + Sbjct: 4 SPTNLNSLPIPPGDFGLPWLGETLNFLNDGDFGK------KRQQQFGPIFKTRLFGKNVI 57 Query: 100 YVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVM 159 ++ LF E + W + P + + + R L Q + Sbjct: 58 FISGALANRFLFTKE----QETFQATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFL 113 Query: 160 APEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQ 219 P ++LP +D + + ++ + G N L R F+ + GE+ Sbjct: 114 -PRTLDSYLPKMDGIVQGYLE-------QWGKAN-EVIWYPQLRRMTFDVAATLFMGEKV 164 Query: 220 GMLEEVVNPEAQRFIDAIYQ-MFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD 278 NP+ + + Q +F +P+ N T K A ++ Sbjct: 165 SQ-----NPQLFPWFETYIQGLFSLPIPLPN----------TLFGKSQRARALLLAELEK 209 Query: 279 IYTQNFYWELRQKGSVHHDYRGILYRLLGDS--KMSFEDIKANVTEMLAGGVDTTSMTLQ 336 I +Q+ D GIL D+ +S ++K + +L G +T + L Sbjct: 210 IIKAR-----QQQPPSEEDALGILLAARDDNNQPLSLPELKDQILLLLFAGHETLTSALS 264 Query: 337 WHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQR 396 + ++ +++ +R E +Q A L+ +P L ++E LRL P R Sbjct: 265 SFCLLLGQHSDIRERVRQEQ-NKLQLSQELTAETLKKMPYLDQVLQEVLRLIPPVGGGFR 323 Query: 397 YLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKD--KNITYFRNLG 454 L+ D + + P LV I +P + DPE FDP R+ + F ++ Sbjct: 324 ELIQDCQFQGFHFPKGWLVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVP 383 Query: 455 FGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTF 511 FG G+R+CLG+ A LEM +F +++ F + ++ P+ + Sbjct: 384 FGGGLRECLGKEFARLEMKLFATRLIQQFDWTLLPGQNLELVVTPSPRPKDNLRVKL 440 >3QZ1-A nrPDB Length = 496 Score = 322 bits (824), Expect = 3e-88, Method: Composition-based stats. Identities = 97/478 (20%), Positives = 175/478 (36%), Gaps = 68/478 (14%) Query: 74 VHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYY 133 + +H + QK GP+YR +LG E V + + E +I WV + Sbjct: 45 LPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTI-----------EEAMIRKWVDFAGRP 93 Query: 134 QRPIGVLLKK----------SAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLH 183 Q P L+ + S WK + L + + + P +D ++++F + Sbjct: 94 QIPSYKLVSQRCQDISLGDYSLLWKAHKK-LTRSALLLGTRSSMEPWVDQLTQEFCERM- 151 Query: 184 RRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHT 243 I + I + FG ++ L + Q D + H Sbjct: 152 -----RVQAGAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQ---DLMKTWDHW 203 Query: 244 SVPMLNL--------PPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVH 295 S+ +L++ P L+RL + +DH+ + K + + + Sbjct: 204 SIQILDMVPFLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAG------QWRDMTD 257 Query: 296 HDYRGILYRLL--GDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLR 353 + +G+ + + G ++ + +V ++ GG +TT+ TL W + + + ++Q L+ Sbjct: 258 YMLQGVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQ 317 Query: 354 AEVLAARHQ---AQGDMATMLQLVPLLKASIKETLRLHPISV-TLQRYLVNDLVLRDYMI 409 E+ +PLL A+I E LRL P+ L + Y I Sbjct: 318 EELDRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDI 377 Query: 410 PAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAE 469 P +V + + T + P F P R+L N + L FG G R CLG +A Sbjct: 378 PEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANPSA---LAFGCGARVCLGESLAR 434 Query: 470 LEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEK---------PISFTFWPFNQEA 518 LE+ + L +L+ F + + + L P+ P P EA Sbjct: 435 LELFVVLARLLQAFTLLPPPVGALP-----SLQPDPYCGVNLKVQPFQVRLQPRGVEA 487 >3MDV-A nrPDB Length = 456 Score = 319 bits (816), Expect = 2e-87, Method: Composition-based stats. Identities = 90/452 (19%), Positives = 167/452 (36%), Gaps = 19/452 (4%) Query: 68 ETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWV 127 E G + + +KYGP+ R + + SV V PE V S N + + + Sbjct: 6 EVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKM---YR 62 Query: 128 AYHQYY-QRPIGVLLKKSA---AWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLH 183 A + +R G L W K R ++ + + + + + + V +L Sbjct: 63 ALQTVFGERLFGQGLVSECNYERWHKQRRVIDL-AFSRSSLVSLMETFNEKAEQLVEILE 121 Query: 184 RRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHT 243 + G + D L A + + FG ML P +Q A+ M Sbjct: 122 AK----ADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQ----AVKLMLEG 173 Query: 244 SVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILY 303 N + K ++ + + + Q L++ V D + Sbjct: 174 ITASRNTLAKFLP-GKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQIL 232 Query: 304 RLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQA 363 + ++ E + N G +T++ L + + E++R ++ L+AEV Sbjct: 233 KAEEGAQ-DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSK 291 Query: 364 QGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALG 423 + L + L +KE+LRL+P + R L + ++ +P T + + Y +G Sbjct: 292 RYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMG 351 Query: 424 REPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 R T+F DP F+P R+ F F G R C+G++ A++E+ + + +L+ Sbjct: 352 RMDTYFEDPLTFNPDRFGPGAPK-PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRL 410 Query: 484 RVEIQHLSDVGTTFNLILMPEKPISFTFWPFN 515 + G L P P+ T P Sbjct: 411 EFRLVPGQRFGLQEQATLKPLDPVLCTLRPRG 442 >6C94-A nrPDB Length = 497 Score = 315 bits (808), Expect = 2e-86, Method: Composition-based stats. Identities = 101/488 (20%), Positives = 184/488 (37%), Gaps = 34/488 (6%) Query: 48 FNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDV 107 + P P + ++TG+ + Q F P++ + ++Y +P+ Sbjct: 21 MDSFPGPPTHWLFGHALEIQKTGSLDKVVTWTQQFPYAHPLWVGQFIGFLNIY--EPDYA 78 Query: 108 ALLFKSEGPNPERFLIPPWVAYHQYYQRPIG--VLLKKSAAWKKDRVALNQEVMAPEATK 165 ++ P + ++ + IG +L+ W + R +++ P Sbjct: 79 KAVYSRGD--------PKAPDVYDFFLQWIGKGLLVLDGPKWFQHR-----KLLTPGFHY 125 Query: 166 NFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEV 225 + L A+ D ++ + +K S DI D+ A +++ FG+ L Sbjct: 126 DVLKPYVAIFADSTRIMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSGLNHR 185 Query: 226 VNPEAQRFIDAIYQM--------FHTSVPMLNLPPDLFRLFR-TKTWKDHVAAWDVIFSK 276 + + M +H + L P R R + DH D + + Sbjct: 186 DSSYYVAVSELTLLMQQRIDSFQYHNDF-IYWLTPHGRRFLRACRAAHDHT---DRVIRQ 241 Query: 277 ADIYTQNFYWELRQKGSVHHDYRGILYRLLGDS--KMSFEDIKANVTEMLAGGVDTTSMT 334 Q+ + + H D+ IL + G+S ++S D++A V + G DTT+ Sbjct: 242 RKAALQDEKEREKIQNRRHLDFLDILLDVRGESGVQLSDTDLRAEVDTFMFEGHDTTTSG 301 Query: 335 LQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTL 394 + W LY MA + Q R EV L + L +KE RL+P + Sbjct: 302 ISWFLYCMALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQV 361 Query: 395 QRYLVNDLV-LRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNIT-YFRN 452 R L + + +PA +L+ + IYAL R + DPE FDP R+ ++ + + Sbjct: 362 YRQLSKPVSFVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAF 421 Query: 453 LGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFW 512 + F G R C+G++ A EM + L F + L L+L + I Sbjct: 422 IPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSVDPLRLPIKLPQLVLRSKNGIHLYLK 481 Query: 513 PFNQEATQ 520 P +A + Sbjct: 482 PLGPKAEK 489 >6DA2-A nrPDB Length = 487 Score = 313 bits (802), Expect = 1e-85, Method: Composition-based stats. Identities = 106/484 (21%), Positives = 196/484 (40%), Gaps = 55/484 (11%) Query: 51 IPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALL 110 IP P +L + + + ++ +KYG ++ G + + DP+ + + Sbjct: 18 IPGPTPLPFLGNILSYHKG----FCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTV 73 Query: 111 FKSEGPNPERFLIPPWVAYHQYYQR----PIGVL-----LKKSAAWKKDRVALNQEVMAP 161 E Y + R P+G + + + WK+ R +++P Sbjct: 74 LVKE-------------CYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLR-----SLLSP 115 Query: 162 EATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGM 221 T L + + + VL R +++ + D ++ + IT+ FG Sbjct: 116 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVN--- 172 Query: 222 LEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYT 281 ++ + NP+ F++ ++ L P + + ++ ++ Sbjct: 173 IDSLNNPQ-DPFVENTKKLLRFDF----LDPFFLSITVFPFLIPILEVLNICVFPREVTN 227 Query: 282 QNFYWELRQKGSVHHD---YRGILYRLLGDSKMSFE----------DIKANVTEMLAGGV 328 R K S D +R +L+ DS+ S E ++ A + G Sbjct: 228 FLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGY 287 Query: 329 DTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLH 388 +TTS L + +YE+A + VQ L+ E+ A + + L + ETLRL Sbjct: 288 ETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF 347 Query: 389 PISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDK-NI 447 PI++ L+R D+ + IP +V + YAL R+P ++ +PE F P R+ K+K NI Sbjct: 348 PIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNI 407 Query: 448 TYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNL--ILMPEK 505 + FG G R C+G R A + M + LI +L+NF + + + +L +L PEK Sbjct: 408 DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEK 467 Query: 506 PISF 509 P+ Sbjct: 468 PVVL 471 >5VBU-A nrPDB Length = 476 Score = 310 bits (795), Expect = 6e-85, Method: Composition-based stats. Identities = 94/494 (19%), Positives = 181/494 (36%), Gaps = 64/494 (12%) Query: 53 SPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFK 112 P G+L+L + ++ + QK+GPIYR LG + V + + Sbjct: 12 PPLAPGFLHLLQ-------PDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTI----- 59 Query: 113 SEGPNPERFLIPPWVAYHQY----------YQRPIGVLLKKSAAWKKDRVALNQEVMAPE 162 E ++ W + P L S WK + L + + Sbjct: 60 ------EEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKK-LTRSALLLG 112 Query: 163 ATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGML 222 + P+++ ++++F + I ++ I + FG++ + Sbjct: 113 IRDSMEPVVEQLTQEFCERM------RAQPGTPVAIEEEFSLLTCSIICYLTFGDK--IK 164 Query: 223 EEVVNPEAQRFIDAI-YQMFHTSVPMLNL--------PPDLFRLFRTKTWKDHVAAWDVI 273 ++ + P + I + H S+ ++++ P L RL + +DH+ + Sbjct: 165 DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLR 224 Query: 274 FSKADIYTQNFYWELRQKGSVHHDYRGIL--YRLLGDSKMSFEDIKANVTEMLAGGVDTT 331 K + + + + + +G+ G ++ + ++L GG +TT Sbjct: 225 QHKESLVAG------QWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETT 278 Query: 332 SMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGD---MATMLQLVPLLKASIKETLRLH 388 + TL W + + + ++Q L+ E+ +PLL A+I E LRL Sbjct: 279 ANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLR 338 Query: 389 PISV-TLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNI 447 P+ L + Y IP T++ + + T + P F P R+L KN Sbjct: 339 PVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNS 398 Query: 448 TYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRV--EIQHLSDVGT-TFNLILMPE 504 R L FG G R CLG +A LE+ + L +L+ F + L + +++ Sbjct: 399 ---RALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKM 455 Query: 505 KPISFTFWPFNQEA 518 +P P A Sbjct: 456 QPFQVRLQPRGMGA 469 >2WX2-A nrPDB Length = 473 Score = 303 bits (775), Expect = 2e-82, Method: Composition-based stats. Identities = 82/446 (18%), Positives = 173/446 (38%), Gaps = 40/446 (8%) Query: 71 THKVHLHHVQNFQ---KYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWV 127 K L +Q + K G ++ +G V DP + + F +P ++ P Sbjct: 34 FGKNPLEFMQRCKRDLKSG-VFTISIGGQRVTIVGDPHEHSRFF-----SPRNEILSPRE 87 Query: 128 AYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIK 187 Y G + +A + + R LN L A ++FV + ++ Sbjct: 88 VYTIMTPV-FGEGVAYAAPYPRMREQLNFLA---------EELTIAKFQNFVPAIQHEVR 137 Query: 188 KAGSGNYSGD-----ISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFH 242 K + N+ D + +D + +FGE L + +N A+ F + +M Sbjct: 138 KFMAENWKEDEGVINLLEDCGAMIINTACQCLFGED---LRKRLN--ARHFAQLLSKMES 192 Query: 243 TSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGIL 302 + +P P L RL ++ + A ++ +I E + + G+L Sbjct: 193 SLIPAAVFMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNTSDLLGGLL 252 Query: 303 YRLLGD-SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMAR--NLKVQDMLRAEVLAA 359 + D ++MS ++ + + G T+++T W + + N K D L E+ Sbjct: 253 KAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEID-- 310 Query: 360 RHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAI 419 AQ + ++ +P + ++E++R P + + R + ++ + Y++P ++ + Sbjct: 311 EFPAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSP 370 Query: 420 YALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINM 479 + F +P +DP R D +GFG GV +C+G++ A L++ L Sbjct: 371 LLSHHDEEAFPNPRLWDPERDEKVDG-----AFIGFGAGVHKCIGQKFALLQVKTILATA 425 Query: 480 LENFRVEIQHLSDVGTTF-NLILMPE 504 + ++ + +++ P Sbjct: 426 FREYDFQLLRDEVPDPDYHTMVVGPT 451 >3L4D-A nrPDB Length = 453 Score = 300 bits (768), Expect = 9e-82, Method: Composition-based stats. Identities = 77/435 (17%), Positives = 169/435 (38%), Gaps = 34/435 (7%) Query: 78 HVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPI 137 ++ +KYG I+ + V D + F P ++ P Y + Sbjct: 29 MLKAKKKYGGIFTMNICGNRITVVGDVHQHSKFFT-----PRNEILSPREVYS-FMVPVF 82 Query: 138 GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGD 197 G + +A + + R LN L A ++F + ++K N++ D Sbjct: 83 GEGVAYAAPYPRMREQLNFLA---------EELTVAKFQNFAPSIQHEVRKFMKANWNKD 133 Query: 198 -----ISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPP 252 I DD + +FGE +A++F + +M +P P Sbjct: 134 EGEINILDDCSAMIINTACQCLFGEDLRKRL-----DARQFAQLLAKMESCLIPAAVFLP 188 Query: 253 DLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGD-SKM 311 + +L ++++ A ++ ++I E ++ + G+L + D ++M Sbjct: 189 WILKLPLPQSYRCRDARAELQDILSEIIIAREKEEAQKDTNTSDLLAGLLGAVYRDGTRM 248 Query: 312 SFEDIKANVTEMLAGGVDTTSMTLQWHLYEMA--RNLKVQDMLRAEVLAARHQAQGDMAT 369 S ++ + + G T+++T W L + RN + L E+ AQ + Sbjct: 249 SQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEID--EFPAQLNYDN 306 Query: 370 MLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFF 429 +++ +P + +E++R P V L R ++ + + Y++P ++ + ++ F Sbjct: 307 VMEEMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDIIACSPLLSHQDEEAF 366 Query: 430 FDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQH 489 +P ++P R + + GFG GV +C+G + L++ L +L ++ E+ Sbjct: 367 PNPREWNPER----NMKLVDGAFCGFGAGVHKCIGEKFGLLQVKTVLATVLRDYDFELLG 422 Query: 490 LSDVGTTFNLILMPE 504 +++ P Sbjct: 423 PLPEPNYHTMVVGPT 437 >2X2N-A nrPDB Length = 475 Score = 283 bits (723), Expect = 2e-76, Method: Composition-based stats. Identities = 74/426 (17%), Positives = 163/426 (38%), Gaps = 36/426 (8%) Query: 88 IYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAW 147 I+ + V DP + + F + + + G + +A + Sbjct: 53 IFTINIVGKRVTIVGDPHEHSRFFLPRNEVLSPREV------YSFMVPVFGEGVAYAAPY 106 Query: 148 KKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGD-----ISDDL 202 + R LN L A ++FV + ++K + N+ D + +D Sbjct: 107 PRMREQLNFLA---------EELTIAKFQNFVPAIQHEVRKFMAANWDKDEGEINLLEDC 157 Query: 203 FRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKT 262 + +FGE +A+RF + +M + +P P L +L ++ Sbjct: 158 STMIINTACQCLFGEDLRKRL-----DARRFAQLLAKMESSLIPAAVFLPILLKLPLPQS 212 Query: 263 WKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGD-SKMSFEDIKANVT 321 + H A ++ ++I + + S G+L + D + MS ++ + Sbjct: 213 ARCHEARTELQKILSEIIIARKAAAVNKDSSTSDLLSGLLSAVYRDGTPMSLHEVCGMIV 272 Query: 322 EMLAGGVDTTSMTLQWHLYEMAR--NLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKA 379 + G T+S+T W + + N+K + LR E+ AQ + ++ +P + Sbjct: 273 AAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEI--EEFPAQLNYNNVMDEMPFAER 330 Query: 380 SIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTR 439 +E++R P + L R ++ D+ + Y++P ++ + + F +P +DP R Sbjct: 331 CARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPER 390 Query: 440 WLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTF-N 498 + +GFG GV +C+G++ L++ L ++ ++ + Sbjct: 391 DEKVEG-----AFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQLLRDEVPDPDYHT 445 Query: 499 LILMPE 504 +++ P Sbjct: 446 MVVGPT 451 >6B82-A nrPDB Length = 509 Score = 273 bits (699), Expect = 1e-73, Method: Composition-based stats. Identities = 103/497 (20%), Positives = 197/497 (39%), Gaps = 54/497 (10%) Query: 32 VPTGEGAGISTRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYRE 91 VP G RSP +P G L ++ H+ +KYG +Y Sbjct: 18 VPAGN------RSPPSLPSLPIIGS-----LMSLVSDS---PPHIFFQDLQKKYGDLYSL 63 Query: 92 KLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDR 151 +G+ + + V + + +G + I S+ WK R Sbjct: 64 MMGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIA-FADYSSTWKFHR 122 Query: 152 VALNQEV-MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESI 210 ++ + M E + + ++ + VL S N + D+ +L R + Sbjct: 123 KMVHGALCMFGEGSVSIEKIICREASSMCEVLTE------SQNSAVDLGPELTRAVTNVV 176 Query: 211 TNVIFGERQGMLEEVVNPE---AQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHV 267 + F + +Q +D + + + D+F + KD Sbjct: 177 CALCFNSSYKRGDAEFESMLQYSQGIVDTVAK---------DSLVDIFPWLQIFPNKDLR 227 Query: 268 AAWDVIFSKADIYTQNFYWELR--QKGSVHHDYRGILYRLLGDSK----------MSFED 315 I D Q Y E + +V D L R S+ ++ + Sbjct: 228 ILRQCISI-RDKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDH 286 Query: 316 IKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVP 375 + V E+ GV+TT+ TL+W + + N +VQ ++ E+ + + + + +P Sbjct: 287 VLMTVGEIFGAGVETTTTTLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLP 346 Query: 376 LLKASIKETLRLHPI-SVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPEN 434 L+A+I E +R+ P+ + + + D + +Y + T V + +++L + + +PE Sbjct: 347 YLEATICEVMRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPEL 406 Query: 435 FDPTRWLSKDKNI---TYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEI---Q 488 FDP R+L+++ + L FG GVR CLG +A++E+ +FL +L+ F +E+ Q Sbjct: 407 FDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQ 466 Query: 489 HLSDVGTTFNLILMPEK 505 L D+ F ++L P+K Sbjct: 467 PLPDLQGKFGVVLQPKK 483 >4R20-A nrPDB Length = 486 Score = 264 bits (675), Expect = 6e-71, Method: Composition-based stats. Identities = 94/445 (21%), Positives = 164/445 (36%), Gaps = 29/445 (6%) Query: 75 HLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQ 134 HL Q +YGP++ G ++ V + V + G Sbjct: 42 HLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLT-QG 100 Query: 135 RPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRD-FVSVLHRRIKKAGSGN 193 S WK R ++ N L + + D L Sbjct: 101 GKDIAFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEELQ------ACRG 154 Query: 194 YSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPD 253 S D+S L R I ++F + +PE Q I + T D Sbjct: 155 QSSDLSVVLMRAVTNVICRLVFSSSY----QPSDPELQTVIQYNDGIVQTI--ARGGLVD 208 Query: 254 LFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLL------- 306 +F R KD + + + + + +K + R +L LL Sbjct: 209 IFPWLRIFPNKDLKRLKECVSIRDQLLYKKLLE--HKKSLTPGEPRDLLDALLIGQQRGS 266 Query: 307 -GDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQG 365 G ++ + + E GV+TTS TL W + + + ++Q+ ++AE+ + Sbjct: 267 GGADDITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRP 326 Query: 366 DMATMLQLVPLLKASIKETLRLHPI-SVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGR 424 + +PLL A + E +R+ P+ + + + D L + +P T V V ++A+ Sbjct: 327 PCLSDRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHH 386 Query: 425 EPTFFFDPENFDPTRWLSK-DKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 +P + PE F+P R+L K T L FG G R C+G +A +E+ +F+ L+ F Sbjct: 387 DPKHWDQPEQFNPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRF 446 Query: 484 RVEIQ---HLSDVGTTFNLILMPEK 505 L D+ F ++L PE+ Sbjct: 447 SFSCPSEASLPDLQGRFGVVLQPER 471 >3DL9-A nrPDB Length = 479 Score = 261 bits (667), Expect = 5e-70, Method: Composition-based stats. Identities = 85/448 (18%), Positives = 162/448 (36%), Gaps = 20/448 (4%) Query: 75 HLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQ 134 H++ + Q YG I+ LG + +V + + V + P + + + Sbjct: 37 HVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADR--PCLPLFMKMTK 94 Query: 135 RPIGVLLKKSAAWKKDRVALNQEVMAPEA-TKNFLPLLDAVSRDFVSVLHRRIKKAGSGN 193 + + W R K+F + ++ F + Sbjct: 95 MGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETY------KG 148 Query: 194 YSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPD 253 D + +IFGER + + F + + SV + N P Sbjct: 149 RPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPW 208 Query: 254 LFRLF---RTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGD-- 308 + L + +++ +D + + + N +L Q Y + + D Sbjct: 209 IGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQH--FVDAYLDEMDQGKNDPS 266 Query: 309 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMA 368 S S E++ +V E++ G +TT+ L+W + MA +Q ++ E+ Sbjct: 267 STFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSW 326 Query: 369 TMLQLVPLLKASIKETLRL-HPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPT 427 +P +A + E LR + + + + D V+R Y IP T V +Y++ + Sbjct: 327 DDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEK 386 Query: 428 FFFDPENFDPTRWLSKDKNITYFRNL-GFGWGVRQCLGRRIAELEMTIFLINMLENFRVE 486 ++ DPE F P R+L L F G R CLG +A +EM +F +L+ F + Sbjct: 387 YWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLH 446 Query: 487 IQH--LSDVGTTFNLILMPEKPISFTFW 512 H + D+ + L P+ + Sbjct: 447 FPHELVPDLKPRLGMTLQPQPYLICAER 474 >4R1Z-A nrPDB Length = 439 Score = 256 bits (654), Expect = 2e-68, Method: Composition-based stats. Identities = 88/436 (20%), Positives = 177/436 (40%), Gaps = 40/436 (9%) Query: 93 LGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRV 152 +G+ + + V + + +G + I S+ WK R Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIA-FADYSSTWKFHRK 59 Query: 153 ALNQEV-MAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESIT 211 ++ + M E + + ++ + VL S N + D+ +L R + Sbjct: 60 MVHGALCMFGEGSVSIEKIICREASSMCEVLTE------SQNSAVDLGPELTRAVTNVVC 113 Query: 212 NVIFGERQGMLEEVVNPE---AQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVA 268 + F + +Q +D + + + D+F + KD Sbjct: 114 ALCFNSSYKRGDAEFESMLQYSQGIVDTVAK---------DSLVDIFPWLQIFPNKDLTI 164 Query: 269 AWDVIFSKADIYTQNFYWELR--QKGSVHHDYRGILYRLLGDSK----------MSFEDI 316 I D Q Y E + +V D L R S+ ++ + + Sbjct: 165 LRQCISI-RDKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHV 223 Query: 317 KANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPL 376 V ++ GV+TT+ L+W + + N +VQ ++ E+ + + + + +P Sbjct: 224 LMTVGDIFGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPY 283 Query: 377 LKASIKETLRLHPI-SVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENF 435 L+A+I+E LR+ P+ + + + D + +Y + T V + +++L + + +PE F Sbjct: 284 LEATIREVLRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELF 343 Query: 436 DPTRWLSKDKNI---TYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEI---QH 489 DP R+L+++ + L FG GVR CLG +A++E+ +FL +L+ F +E+ Q Sbjct: 344 DPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQP 403 Query: 490 LSDVGTTFNLILMPEK 505 L D+ F ++L P+K Sbjct: 404 LPDLQGKFGVVLQPKK 419 >5W0C-A nrPDB Length = 477 Score = 250 bits (638), Expect = 1e-66, Method: Composition-based stats. Identities = 80/481 (16%), Positives = 173/481 (35%), Gaps = 35/481 (7%) Query: 52 PSPGDNGWLN-LYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALL 110 P P + + G + + YGP++ G V + E V Sbjct: 14 PGPTPLPVIGNILQI----GIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEA 69 Query: 111 FKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNF--- 167 G I P + R G++ WK+ R + +NF Sbjct: 70 LIDLGEEFSGRGIFP---LAERANRGFGIVFSNGKKWKEIRR------FSLMTLRNFGMG 120 Query: 168 LPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVN 227 ++ ++ L ++K + L I ++IF +R ++ Sbjct: 121 KRSIEDRVQEEARCLVEELRKTKASPCDPTF--ILGCAPCNVICSIIFHKRFDYKDQQFL 178 Query: 228 PEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWE 287 ++ + I + + + N + + + +V F K+ I + + Sbjct: 179 NLMEKLNENIKILSSPWIQICN---NFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQ 235 Query: 288 LRQKGSVHHDYRGILYRLLGD------SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYE 341 + D+ + S+ + E ++ ++ G +TTS TL++ L Sbjct: 236 ESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLL 295 Query: 342 MARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRL-HPISVTLQRYLVN 400 + ++ +V ++ E+ + + +P A + E R + +L + Sbjct: 296 LLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTC 355 Query: 401 DLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRN-LGFGWGV 459 D+ R+Y+IP T + +++ ++ + F +PE FDP +L + N + + F G Sbjct: 356 DIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGK 415 Query: 460 RQCLGRRIAELEMTIFLINMLENFRVE----IQHLSDVGTTFNLILMPEKPISFTFWPFN 515 R C+G +A +E+ +FL ++L+NF ++ ++L +P F P + Sbjct: 416 RICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP-PFYQLCFIPIH 474 Query: 516 Q 516 Sbjct: 475 H 475 >1N6B-A nrPDB Length = 473 Score = 250 bits (637), Expect = 2e-66, Method: Composition-based stats. Identities = 89/484 (18%), Positives = 178/484 (36%), Gaps = 44/484 (9%) Query: 52 PSPGDNGWLN-LYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALL 110 P P + + + + + YGP++ LG +V + E V Sbjct: 13 PGPTPFPIIGNILQI----DAKDISKSLTKFSECYGPVFTVYLGMKPTVVLHGYEAVKEA 68 Query: 111 FKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNF--- 167 G P + + + +G+ + WK+ R + +NF Sbjct: 69 LVDLGEEFAGRGSVPIL---EKVSKGLGIAFSNAKTWKEMRR------FSLMTLRNFGMG 119 Query: 168 LPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVN 227 ++ ++ L ++K + L I +VIF R +E Sbjct: 120 KRSIEDRIQEEARCLVEELRKTNASPCDPTF--ILGCAPCNVICSVIFHNRFDYKDE--- 174 Query: 228 PEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWE 287 E + ++++ H +V +L P L D+ K Y +NF E Sbjct: 175 -EFLKLMESL----HENVELLGT-PWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIME 228 Query: 288 LRQKGSVHHDYRG---------ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH 338 ++ D I + + + E + V+++ G +TTS TL++ Sbjct: 229 KVKEHQKLLDVNNPRDFIDCFLIKMEQENNLEFTLESLVIAVSDLFGAGTETTSTTLRYS 288 Query: 339 LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVT-LQRY 397 L + ++ +V ++ E+ + + +P A I E R + T L Sbjct: 289 LLLLLKHPEVAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHA 348 Query: 398 LVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYF-RNLGFG 456 + D+ R+Y IP T + ++ ++ + F +P+ FDP +L + N + F Sbjct: 349 VTRDVRFRNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFS 408 Query: 457 WGVRQCLGRRIAELEMTIFLINMLENFRVE-IQHLSDVGTTF---NLILMPEKPISFTFW 512 G R C+G +A +E+ +FL ++L+NF+++ + D+ T + +P F Sbjct: 409 AGKRMCVGEGLARMELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVP-PSYQLCFI 467 Query: 513 PFNQ 516 P + Sbjct: 468 PIHH 471 >2NNH-A nrPDB Length = 476 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 83/483 (17%), Positives = 169/483 (34%), Gaps = 39/483 (8%) Query: 52 PSPGDNGWLN-LYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALL 110 P P + + + + YGP++ G V E V Sbjct: 13 PGPTPLPIIGNMLQI----DVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEA 68 Query: 111 FKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNF--- 167 G P Q + +G++ WK+ R + +NF Sbjct: 69 LIDNGEEFSGRGNSP---ISQRITKGLGIISSNGKRWKEIRR------FSLTTLRNFGMG 119 Query: 168 LPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVN 227 ++ ++ L ++K + L I +V+F +R ++ Sbjct: 120 KRSIEDRVQEEAHCLVEELRKTKASPCDPTF--ILGCAPCNVICSVVFQKRFDYKDQNFL 177 Query: 228 PEAQRFIDAIYQMFHTSVPMLNLPPDL---FRLFRTKTWKDHVAAWDVIFSKADIYTQNF 284 +RF + + + + N P L F K K+ I K Sbjct: 178 TLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVK-----E 232 Query: 285 YWELRQKGSVHHDYRGILYRLLGD-----SKMSFEDIKANVTEMLAGGVDTTSMTLQWHL 339 + + L ++ + S+ + E++ V ++ G +TTS TL++ L Sbjct: 233 HQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGL 292 Query: 340 YEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHP-ISVTLQRYL 398 + ++ +V ++ E+ + + +P A + E R + + + Sbjct: 293 LLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAV 352 Query: 399 VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYF-RNLGFGW 457 D R+Y+IP T + + ++ + F +P FDP +L K+ N + F Sbjct: 353 TTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSA 412 Query: 458 GVRQCLGRRIAELEMTIFLINMLENFRVE----IQHLSDVGTTFNLILMPEKPISFTFWP 513 G R C G +A +E+ +FL +L+NF ++ +++L+ T ++ +P F P Sbjct: 413 GKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP-PSYQICFIP 471 Query: 514 FNQ 516 + Sbjct: 472 VHH 474 >3IBD-A nrPDB Length = 476 Score = 247 bits (630), Expect = 1e-65, Method: Composition-based stats. Identities = 79/452 (17%), Positives = 154/452 (34%), Gaps = 36/452 (7%) Query: 83 QKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLK 142 +KYG ++ LG V + E + + +A + R GV+ Sbjct: 41 EKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGK---IAMVDPFFRGYGVIFA 97 Query: 143 KSAAWKKDRVALNQEVMAPEATKNF---LPLLDAVSRDFVSVLHRRIKKAGSGNYSGDIS 199 WK R + ++F ++ ++ L ++K+ Sbjct: 98 NGNRWKVLRR------FSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFL 151 Query: 200 DDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFR 259 I +++FG+R + E + ++ YQ F + +LF F Sbjct: 152 --FQSITANIICSIVFGKRF----HYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFL 205 Query: 260 TKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLL----------GDS 309 H V + +I + + + ++ L S Sbjct: 206 KHFPGAHR---QVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSNAHS 262 Query: 310 KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMAT 369 + S +++ N + G +TTS TL++ M + V + + E+ + Sbjct: 263 EFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELH 322 Query: 370 MLQLVPLLKASIKETLRLHP-ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTF 428 +P +A I E R + + + + R Y+IP T V + + +P + Sbjct: 323 DRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHY 382 Query: 429 FFDPENFDPTRWLSKDKNITY-FRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRV-E 486 F P+ F+P +L + + + F G R CLG IA E+ +F +L+NF + Sbjct: 383 FEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMAS 442 Query: 487 IQHLSDVGTTFNLILMPEKPI--SFTFWPFNQ 516 D+ T + + P F P + Sbjct: 443 PVAPEDIDLTPQECGVGKIPPTYQIRFLPRHH 474 >5E0E-A nrPDB Length = 463 Score = 246 bits (628), Expect = 2e-65, Method: Composition-based stats. Identities = 73/434 (16%), Positives = 148/434 (34%), Gaps = 30/434 (6%) Query: 83 QKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLK 142 +KYG ++ LG V + E + + +A + R GV+ Sbjct: 32 EKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGT---IAVVEPIFRGYGVVFA 88 Query: 143 KSAAWKKDRVALNQEVMAPEATKNF---LPLLDAVSRDFVSVLHRRIKKAGSGNYSGDIS 199 WK R + ++F ++ ++ L +K+ Sbjct: 89 NGERWKALRR------FSLVTMRDFGMGKRSVEERIQEEARCLVEEFRKSQGAPLDPTFL 142 Query: 200 DDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFR 259 I +++FGER + F + + S + L + F Sbjct: 143 FQC--ITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFSGFLKYF- 199 Query: 260 TKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGI-LYRLLG-----DSKMSF 313 + ++ I S D+ L R+ ++ Sbjct: 200 --PGTHRQISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSNQHTEFDH 257 Query: 314 EDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQL 373 +++ +V + G +T+S TL++ M + V + ++ E+ + Sbjct: 258 QNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLEDRTK 317 Query: 374 VPLLKASIKETLRLHP-ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDP 432 +P +A I E R I + + + D + R Y++P T V + + +P +F P Sbjct: 318 MPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQYFEQP 377 Query: 433 ENFDPTRWLSKDKNITYF-RNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLS 491 + F+P +L + + + F G R CLG IA E+ +F +L+NF + Sbjct: 378 DTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSLSSPVAP 437 Query: 492 DVGTTFNLILMPEK 505 ++ L P++ Sbjct: 438 K-----DIDLSPKE 446 >4GQS-A nrPDB Length = 477 Score = 245 bits (626), Expect = 3e-65, Method: Composition-based stats. Identities = 85/480 (17%), Positives = 176/480 (36%), Gaps = 33/480 (6%) Query: 52 PSPGDNGWLN-LYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALL 110 P P + + V + YGP++ G V + E V Sbjct: 14 PGPTPLPVIGNILQI----DIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEA 69 Query: 111 FKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNF--- 167 G P + R G++ WK+ R + +NF Sbjct: 70 LIDLGEEFSGRGHFP---LAERANRGFGIVFSNGKRWKEIRR------FSLMTLRNFGMG 120 Query: 168 LPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVN 227 ++ ++ L ++K + L I ++IF +R ++ Sbjct: 121 KRSIEDRVQEEARCLVEELRKTKASPCDPTF--ILGCAPCNVICSIIFQKRFDYKDQQFL 178 Query: 228 PEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWE 287 ++ + I + + + N P + F + ++ F ++DI + + Sbjct: 179 NLMEKLNENIRIVSTPWIQICNNFPTIIDYF---PGTHNKLLKNLAFMESDILEKVKEHQ 235 Query: 288 LRQKGSVHHDYRG-ILYRLLGD-----SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYE 341 + D+ L ++ + S+ + E++ ++L G +TTS TL++ L Sbjct: 236 ESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLL 295 Query: 342 MARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRL-HPISVTLQRYLVN 400 + ++ +V ++ E+ + + +P A + E R I +L + Sbjct: 296 LLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTC 355 Query: 401 DLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITY-FRNLGFGWGV 459 D+ R+Y+IP T + ++ ++ + F +PE FDP +L + N + F G Sbjct: 356 DVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGK 415 Query: 460 RQCLGRRIAELEMTIFLINMLENFRVE-IQHLSDVGTTFNLILMPEKPIS--FTFWPFNQ 516 R C+G +A +E+ +FL +L+NF ++ + D+ TT + P F P + Sbjct: 416 RICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPIHH 475 >5E58-A nrPDB Length = 493 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 72/446 (16%), Positives = 141/446 (31%), Gaps = 24/446 (5%) Query: 83 QKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLK 142 +KYG ++ LG V + E + + +A + G++ Sbjct: 60 EKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGT---IAVIKPVIGDYGMIFS 116 Query: 143 KSAAWKKDRVALNQEVMAPEATKNF---LPLLDAVSRDFVSVLHRRIKKAGSGNYSGDIS 199 WK R + ++F ++ ++ L ++K+ Sbjct: 117 NGERWKVLRR------FSLATMRDFGMGKRSVEDRIQEEAQCLVEELQKSQGAPLDPTFL 170 Query: 200 DDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFR 259 I +++FGER + F M S + L + F Sbjct: 171 FQC--ITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFSGFMKYF- 227 Query: 260 TKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLL----GDSKMSFED 315 + I + L +L ++ ++ Sbjct: 228 PGAHRQITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSNQHTEFHHQN 287 Query: 316 IKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVP 375 + +V + G +TTS TL++ M + V + ++ E+ + +P Sbjct: 288 LLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLEDRTKMP 347 Query: 376 LLKASIKETLRLHP-ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPEN 434 A I E R + + D + R Y++P T V + + +P +F P Sbjct: 348 YTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQYFEQPGT 407 Query: 435 FDPTRWLSKDKNITYF-RNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLS-- 491 F+P +L + + + F G R CLG IA E+ +F +L+NF V Sbjct: 408 FNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSVSSSVAPKD 467 Query: 492 -DVGTTFNLILMPEKPISFTFWPFNQ 516 D+ + I + +F + Sbjct: 468 IDLSPKESGIGKVPQTYQISFLARHH 493 >4H1N-A nrPDB Length = 479 Score = 245 bits (625), Expect = 4e-65, Method: Composition-based stats. Identities = 87/474 (18%), Positives = 161/474 (33%), Gaps = 31/474 (6%) Query: 52 PSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLF 111 P P L G + L + KYG ++ LG+ V + + + Sbjct: 13 PGPSPLPVLGNLLQMDRKGLLRSFLRLRE---KYGDVFTVYLGSRPVVVLCGTDAIREAL 69 Query: 112 KSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNF---L 168 + +A + GV+ W+ R + ++F Sbjct: 70 VDQAEAFSGRGK---IAVVDPIFQGYGVIFANGERWRALRR------FSLATMRDFGMGK 120 Query: 169 PLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNP 228 ++ ++ L ++K+ + I +++FG+R + P Sbjct: 121 RSVEERIQEEARCLVEELRKSKGALLDNTLL--FHSITSNIICSIVFGKRFDYKD----P 174 Query: 229 EAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQN-FYWE 287 R +D +Q F + +LF F H + + Q+ Sbjct: 175 VFLRLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHR 234 Query: 288 LRQKGSVHHDYRGI-LYRLLGD-----SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYE 341 S D+ + L R+ D S+ +++ V + A G +TTS TL++ Sbjct: 235 ATLDPSNPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLL 294 Query: 342 MARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRL-HPISVTLQRYLVN 400 M + V + ++ E+ + +P A I E RL I + + Sbjct: 295 MLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTK 354 Query: 401 DLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFR-NLGFGWGV 459 D R Y+IP T V + + +P +F P F+P +L + + + F G Sbjct: 355 DTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGK 414 Query: 460 RQCLGRRIAELEMTIFLINMLENFRV-EIQHLSDVGTTFNLILMPEKPISFTFW 512 R CLG IA E+ +F +L+NF + D+ T + P S+ Sbjct: 415 RICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNVPPSYQIR 468 >2HI4-A nrPDB Length = 495 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 91/494 (18%), Positives = 171/494 (34%), Gaps = 53/494 (10%) Query: 39 GISTRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVES 98 G+ R P+ P P L H HL + Q+YG + + ++G+ Sbjct: 6 GLRPRVPKGLKSPPEPWGWPLLG--HVLTLG--KNPHLALSRMSQRYGDVLQIRIGSTPV 61 Query: 99 VYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLL----KKSAAWKKDRV-- 152 + + + + +G + + + G L W R Sbjct: 62 LVLSRLDTIRQALVRQGDDFKGR-----PDLYTSTLITDGQSLTFSTDSGPVWAARRRLA 116 Query: 153 --ALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESI 210 ALN +A + + L+ L R+++ +G D + + I Sbjct: 117 QNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVI 176 Query: 211 TNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAW 270 + FG+ + + + + + +S L+ P L L Sbjct: 177 GAMCFGQHFPESSDEMLSLVKNTHEFVET--ASSGNPLDFFPILRYLPNP---------- 224 Query: 271 DVIFSKADIYTQNFYWELRQKGSVHHD------YRGILYRLLGDSK---------MSFED 315 + + Q F W L++ H+ R I L SK + E Sbjct: 225 --ALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEK 282 Query: 316 IKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVP 375 I V ++ G DT + + W L + ++Q ++ E+ + + + +P Sbjct: 283 IVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLP 342 Query: 376 LLKASIKETLRLHP-ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPEN 434 L+A I ET R + T+ D L + IP K V V + + +P + DP Sbjct: 343 YLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSE 402 Query: 435 FDPTRWLSKDK----NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHL 490 F P R+L+ D + + FG G R+C+G +A+ E+ +FL +L+ + Sbjct: 403 FRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 462 Query: 491 --SDVGTTFNLILM 502 D+ + L + Sbjct: 463 VKVDLTPIYGLTMK 476 >5UYS-A nrPDB Length = 494 Score = 240 bits (613), Expect = 8e-64, Method: Composition-based stats. Identities = 87/482 (18%), Positives = 175/482 (36%), Gaps = 44/482 (9%) Query: 42 TRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYV 101 + P+ +P + F G +H + + +KYGPIY ++G +V V Sbjct: 7 AKYPKSLLSLP------LVGSLPFLPRHG--HMHNNFFKLQKKYGPIYSVRMGTKTTVIV 58 Query: 102 IDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRV-ALNQEVMA 160 + + +G + + R A W+ R A+ + Sbjct: 59 GHHQLAKEVLIKKGKDFSGRPQMATLDIAS-NNRKGIAFADSGAHWQLHRRLAMATFALF 117 Query: 161 PEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQG 220 + + ++ +L S DIS +F I+ + F Sbjct: 118 KDGDQKLEKIICQEISTLCDMLATH------NGQSIDISFPVFVAVTNVISLICFNTSYK 171 Query: 221 MLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRT---KTWKDHVAAWDVIFSKA 277 + +N Q + + I +++L P L K D++ Sbjct: 172 NGDPELN-VIQNYNEGIIDNLSKD-SLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKIL 229 Query: 278 DIYTQNFYWELRQKGSVHHDYRGILYRLLGDSK-----------MSFEDIKANVTEMLAG 326 + Y + F + S+ + ++ + +S I + ++ Sbjct: 230 ENYKEKF-----RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGA 284 Query: 327 GVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLR 386 GV+TT+ ++W L + N +V+ L E+ ++ + + LL+A+I+E LR Sbjct: 285 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLR 344 Query: 387 LHPISVTL-QRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDK 445 L P++ L D + ++ + T V + ++AL + P+ F P R+L+ Sbjct: 345 LRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAG 404 Query: 446 N---ITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILM 502 L FG G R C+G +A E+ + + +L+ F +E+ D G +L + Sbjct: 405 TQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEV---PDDGQLPSLEGI 461 Query: 503 PE 504 P+ Sbjct: 462 PK 463 >3E6I-A nrPDB Length = 476 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 71/457 (15%), Positives = 160/457 (35%), Gaps = 30/457 (6%) Query: 53 SPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFK 112 PG + + ++ + + Q++GP++ +G+ V + + V Sbjct: 12 PPGPFPLPIIGNLFQLE-LKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALL 70 Query: 113 SEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNF---LP 169 P A+H + R G++ WK R + +N+ Sbjct: 71 DYKDEFSGRGDLP--AFHAHRDR--GIIFNNGPTWKDIRR------FSLTTLRNYGMGKQ 120 Query: 170 LLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPE 229 ++ + L ++K D + + I +++F + +E Sbjct: 121 GNESRIQREAHFLLEALRKTQ--GQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL 178 Query: 230 AQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELR 289 F + + + + + N P H + + ++ + Sbjct: 179 MYLFNENFHLLSTPWLQLYNNFPSFLHYL----PGSHRKVIKNVAEVKEYVSERVKEHHQ 234 Query: 290 QKGS--VHHDYRGILYRLLGDSKM-----SFEDIKANVTEMLAGGVDTTSMTLQWHLYEM 342 +L + + + + I V ++ G +TTS TL++ L + Sbjct: 235 SLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLIL 294 Query: 343 ARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHP-ISVTLQRYLVND 401 + ++++ L E+ ++ Q +P + A + E R + L D Sbjct: 295 MKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRD 354 Query: 402 LVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNL-GFGWGVR 460 + R Y+IP T+V + ++ + F DPE F P +L+++ Y F G R Sbjct: 355 TIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKR 414 Query: 461 QCLGRRIAELEMTIFLINMLENFRVE-IQHLSDVGTT 496 C G +A +E+ + L +L++F ++ + D+ + Sbjct: 415 VCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLS 451 >6DWN-A nrPDB Length = 491 Score = 238 bits (608), Expect = 4e-63, Method: Composition-based stats. Identities = 83/481 (17%), Positives = 165/481 (34%), Gaps = 52/481 (10%) Query: 53 SPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFK 112 PG GW + H HL + Q+YG + + ++G+ V + + + Sbjct: 13 PPGPWGWPLIGHMLTLG--KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALV 70 Query: 113 SEGPNPERFLIPPWVAYHQYYQRPIGVLL----KKSAAWKKDRVALNQEVMAPEATKNFL 168 +G + + + + G + W R + + + Sbjct: 71 RQGDDFKGR-----PDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPA 125 Query: 169 PLLDAVSRDFV----SVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEE 224 + V VL +++ +G + + I + FG R Sbjct: 126 SSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDH-NH 184 Query: 225 VVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNF 284 + ++ + P + P L L + + F Sbjct: 185 QELLSLVNLNNNFGEVVGSGNPA-DFIPILRYLPNP------------SLNAFKDLNEKF 231 Query: 285 YWELRQKGSVHHD------YRGILYRLL-----------GDSKMSFEDIKANVTEMLAGG 327 Y +++ H+ R I L+ + ++S E I V ++ G Sbjct: 232 YSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAG 291 Query: 328 VDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRL 387 DT + + W L + N +VQ ++ E+ +++ + +P ++A I ET R Sbjct: 292 FDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRH 351 Query: 388 HP-ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKN 446 + T+ D L+ + IP V V + + + + +P F P R+L+ D Sbjct: 352 SSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGA 411 Query: 447 ITY---FRNLGFGWGVRQCLGRRIAELEMTIFLINMLEN--FRVEIQHLSDVGTTFNLIL 501 I + + FG G R+C+G IA E+ +FL +L+ F V + D+ + L + Sbjct: 412 IDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTM 471 Query: 502 M 502 Sbjct: 472 K 472 >2PG7-A nrPDB Length = 476 Score = 237 bits (605), Expect = 7e-63, Method: Composition-based stats. Identities = 75/482 (15%), Positives = 180/482 (37%), Gaps = 37/482 (7%) Query: 52 PSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLF 111 P P ++ Y T +++ ++ ++YGP++ LG V + + V Sbjct: 13 PGPTPLPFIGNYLQLN---TEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREAL 69 Query: 112 KSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNF---L 168 + A + + GV+ K+ R + ++F Sbjct: 70 VDQAEEFSGRGEQ---ATFDWVFKGYGVVFSNGERAKQLRR------FSIATLRDFGVGK 120 Query: 169 PLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNP 228 ++ ++ L ++ G N L R I++++FG+R ++ Sbjct: 121 RGIEERIQEEAGFLIDALRGTGGANIDPTFF--LSRTVSNVISSIVFGDRFDYKDKEFLS 178 Query: 229 EAQRFIDAIYQMFHTSVPMLNLPPD-LFRLFRTKTWKDHVAAWDVIFSKADIYTQN-FYW 286 + + ++ + + + L + A+ ++ D + + Sbjct: 179 LLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQ-----QAFQLLQGLEDFIAKKVEHN 233 Query: 287 ELRQKGSVHHDYRGILYRLLG------DSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLY 340 + + D+ + +++ +++ ++ GG +T S TL++ Sbjct: 234 QRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFL 293 Query: 341 EMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPI-SVTLQRYLV 399 + ++ +V+ + E+ + + +P ++A I E R + ++L R + Sbjct: 294 LLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVK 353 Query: 400 NDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYF-RNLGFGWG 458 D RD+ +P T V + ++ R+P+FF +P++F+P +L++ + F G Sbjct: 354 KDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIG 413 Query: 459 VRQCLGRRIAELEMTIFLINMLENFRVEIQHLS---DVGTTF-NLILMPEKPISFTFWPF 514 R C G +A +E+ +F +++NFR++ DV +P +F P Sbjct: 414 KRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYT-MSFLPR 472 Query: 515 NQ 516 + Sbjct: 473 HH 474 >3JUS-A nrPDB Length = 461 Score = 235 bits (598), Expect = 5e-62, Method: Composition-based stats. Identities = 81/452 (17%), Positives = 163/452 (36%), Gaps = 48/452 (10%) Query: 71 THKVHLHHVQN-FQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAY 129 K + ++N ++KYGP++ + Y++ + ALLF S+ + + Y Sbjct: 29 FGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDV-----Y 83 Query: 130 HQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKK- 188 + G + + V + L A + VS++ + K+ Sbjct: 84 SRLTTPVFGKGVAYD---------VPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEY 134 Query: 189 ---AGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSV 245 G ++ + L + ++ + G+ + ++ + Sbjct: 135 FESWGESG-EKNVFEALSELIILTASHCLHGKEIR------SQLNEKVAQLYADLDGGFS 187 Query: 246 PMLNLPPDLFRLFRTKTW-KDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYR 304 L P L + + H D+ FY ++++ IL Sbjct: 188 HAAWLLPGWLPLPSFRRRDRAHREIKDI-----------FYKAIQKRRQSQEKIDDILQT 236 Query: 305 LLGDS-----KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAA 359 LL + ++ +++ + +L G T+S T W + +AR+ +Q E Sbjct: 237 LLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTV 296 Query: 360 RHQAQGDMA-TMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVA 418 + + L+ + LL IKETLRL P + + R + Y IP V V+ Sbjct: 297 CGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVS 356 Query: 419 IYALGREPTFFFDPENFDPTRWLSKDK-NITYFRNLGFGWGVRQCLGRRIAELEMTIFLI 477 R + + +F+P R+L + + F + FG G +C+G A +++ Sbjct: 357 PTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWS 416 Query: 478 NMLENFRVEI--QHLSDVGTTFNLILMPEKPI 507 ML + ++ + V T +I PE P+ Sbjct: 417 TMLRLYEFDLIDGYFPTVNYT-TMIHTPENPV 447 >6AYB-A nrPDB Length = 466 Score = 228 bits (582), Expect = 3e-60, Method: Composition-based stats. Identities = 77/443 (17%), Positives = 165/443 (37%), Gaps = 21/443 (4%) Query: 78 HVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPI 137 + N +KYG ++ + E ++ P+ + FK+ + +++ + Sbjct: 36 IIDNSKKYGDVFTATILGKEMTFLNHPKILDTFFKATDNELSLRDV------YRFMRPVF 89 Query: 138 GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGD 197 G + A +R+ + ++ T + + D + ++K+ G + D Sbjct: 90 GTGVVYDAD-STERMMEQVKFVSSGLTTARFRVFVDIFED---EIAHKVKELGPEG-TVD 144 Query: 198 ISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRL 257 +++ + + + + G+ N + + P+ P L Sbjct: 145 VAELMADLIIFTASRCLLGDEVRQYLSEKN-----LGKLYHDIDDGISPLSFFYPSLPAP 199 Query: 258 FRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDS-KMSFEDI 316 R K K + + K + E S +L + D +++ Sbjct: 200 KRDKARKAVGEIFQELLDKRRE-EHKKHPERLLDESKMDVVDHLLTQKYKDGQELTDVHR 258 Query: 317 KANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPL 376 + L G T+S+T W L + N KV + +R E + + + Sbjct: 259 IGILIAGLFAGQHTSSITSSWTLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDY 318 Query: 377 LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFD 436 L+A +KE LR++P + + R Y+IP ++ V+ GR + +P+ FD Sbjct: 319 LEACMKEALRMYPPLIMIMRMARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFD 378 Query: 437 PTRWLSKDKNITY-FRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVE-IQHLSDVG 494 P R + ++ + + + FG G +C+G A L++ + +L F +E I + D Sbjct: 379 PERLTERKEHEKFKYGAVPFGAGRHKCIGENFALLQVKSIISILLRYFDMEYIGKIPDPS 438 Query: 495 TTFNLILMPEKPISFTFWPFNQE 517 T +L++ P P + Q+ Sbjct: 439 YT-SLVVGPSPPTRMRYKLRKQQ 460 >6IQ5-A nrPDB Length = 463 Score = 228 bits (581), Expect = 4e-60, Method: Composition-based stats. Identities = 82/468 (17%), Positives = 180/468 (38%), Gaps = 39/468 (8%) Query: 72 HKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQ 131 HL + ++YG +++ +LG+ V + + +G P + ++ Sbjct: 1 QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADR--PSFASFRV 58 Query: 132 YYQRPIGVLLKKSAAWKKDRVA---LNQEVMA--PEATKNFLPLLDAVSRDFVSVLHRRI 186 S WK R A + + P + + + + +R+ V++L + Sbjct: 59 VSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALL---V 115 Query: 187 KKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVP 246 + + G + D ++ V FG R + PE + + + T Sbjct: 116 RGSADGAF-LDPRPLTVVAVANVMSAVCFGCRYSHDD----PEFRELLSHNEEFGRTVGA 170 Query: 247 --MLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYR 304 ++++ P L + ++ + + + + + R ++ Sbjct: 171 GSLVDVMPWLQYFPNPV--RTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDA 228 Query: 305 LL-------------GDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDM 351 + G +++ E++ A +T++ DT S LQW L R VQ Sbjct: 229 FILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTR 288 Query: 352 LRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHP-ISVTLQRYLVNDLVLRDYMIP 410 ++AE+ + + +P + A + E +R + VT+ + + Y IP Sbjct: 289 VQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIP 348 Query: 411 AKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITY---FRNLGFGWGVRQCLGRRI 467 T+V V +++ +P + +PENFDP R+L KD I R + F G R+C+G + Sbjct: 349 KDTVVFVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEEL 408 Query: 468 AELEMTIFLINMLEN--FRVEIQHLSDVGTTFNLILMPEKP-ISFTFW 512 +++++ +F+ + FR + + ++ L + P+ ++ T Sbjct: 409 SKMQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLR 456 >3EL3-A nrPDB Length = 467 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 100/478 (20%), Positives = 170/478 (35%), Gaps = 36/478 (7%) Query: 34 TGEGAGISTRSPR----PFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIY 89 T E TR+P P P G L H WR + L + + +G + Sbjct: 2 TVESVNPETRAPAAPGAPELREPPVAGGGVPLLGHGWR---LARDPLAFMSQLRDHGDVV 58 Query: 90 REKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKK 149 R KLG V +PE L + + P W + + GV ++ Sbjct: 59 RIKLGPKTVYAVTNPELTGALALNPDYHIAG---PLWESLEGLLGKE-GVATANGPLHRR 114 Query: 150 DRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFES 209 R + P + +P + + L R + + D + + FR A Sbjct: 115 QRRTIQ-----PAFRLDAIPAYGPIMEEEAHALTERWQ----PGKTVDATSESFRVAVRV 165 Query: 210 ITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPD-LFRLFRTKTWKDHVA 268 + + + ++ A+R A+ +F + +P L+RL + + A Sbjct: 166 AARCL------LRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDA 219 Query: 269 AWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGD--SKMSFEDIKANVTEMLAG 326 D+ +I + R G D L D + ++I V +L Sbjct: 220 LADLHLLVDEIIAER-----RASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTP 274 Query: 327 GVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLR 386 G +T + T+ W L +A + + D +R EV A + + I E +R Sbjct: 275 GSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVR-KLRHTGNVIVEAMR 333 Query: 387 LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWL-SKDK 445 L P L R V + L Y IPA + + YA+ R+P + D FDP RWL + Sbjct: 334 LRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAA 393 Query: 446 NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMP 503 N+ + F G R+C + ++T+ + +R E S+ + L P Sbjct: 394 NVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRP 451 >3TBG-A nrPDB Length = 479 Score = 225 bits (572), Expect = 5e-59, Method: Composition-based stats. Identities = 73/457 (15%), Positives = 150/457 (32%), Gaps = 17/457 (3%) Query: 70 GTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAY 129 Q +++G ++ +L V + V + G + P Sbjct: 28 DFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQI 87 Query: 130 HQYYQRPIGVLLK-KSAAWKKDRVALNQEVMAPEA-TKNFLPLLDAVSRDFVSVLHRRIK 187 + R GV L AW++ R + K+ + + + Sbjct: 88 LGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSG 147 Query: 188 KAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPM 247 + N D + I ++ G R + + + + + Sbjct: 148 RPFRPNGLLD------KAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREV 201 Query: 248 LNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGS-VHHDYRGILYRLL 306 LN P L + + + W+ Q + + + + Sbjct: 202 LNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAK 261 Query: 307 GDSKMS--FEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQ 364 G+ + S E+++ V ++ + G+ TTS TL W L M + VQ ++ E+ Q + Sbjct: 262 GNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVR 321 Query: 365 GDMATMLQLVPLLKASIKETLRLHP-ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALG 423 +P A I E R + + + D+ ++ + IP T + + ++ Sbjct: 322 RPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVL 381 Query: 424 REPTFFFDPENFDPTRWLSKDKNI-TYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLEN 482 ++ + P F P +L + L F G R CLG +A +E+ +F ++L++ Sbjct: 382 KDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQH 441 Query: 483 FRVEI---QHLSDVGTTFNLILMPEKPISFTFWPFNQ 516 F + Q F ++ P P P + Sbjct: 442 FSFSVPTGQPRPSHHGVFAFLVSPS-PYELCAVPRHH 477 >4WMZ-A nrPDB Length = 539 Score = 221 bits (563), Expect = 6e-58, Method: Composition-based stats. Identities = 82/490 (16%), Positives = 166/490 (33%), Gaps = 56/490 (11%) Query: 58 GWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPN 117 W+ + + +KYG I+ L + P+ +F N Sbjct: 64 PWVGSAVVYGMKPYE----FFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVF-----N 114 Query: 118 PERFLIPPWVAYHQYYQRPIGVLLKKSAAWKK--DRVALNQEVMAPEATKNFLPLLDAVS 175 + + AY G + + ++ + + EA K+++PL+ Sbjct: 115 AKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEV 174 Query: 176 RDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFID 235 + + + + D+ + + + G+ + F Sbjct: 175 YKYFRD-SKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDT------DFAY 227 Query: 236 AIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVH 295 + P+ + P+L +H D + E R+ + Sbjct: 228 LYSDLDKGFTPINFVFPNL--------PLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQ 279 Query: 296 HDYRGILYRLLGDS------KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQ 349 R ++ L+ +S KM+ ++I + +L GG T++ T W L +A VQ Sbjct: 280 D--RDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQ 337 Query: 350 DMLRAEVLAARHQAQGDMA-TMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD-- 406 L E + + ++ +LQ +PLL +IKETLR+H +L R ++ D+ + + Sbjct: 338 QELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTS 397 Query: 407 YMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKN-----------------ITY 449 Y+IPA V V+ +F + F+ RW + + Sbjct: 398 YVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVS 457 Query: 450 FRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTT--FNLILMPEKPI 507 L FG G +C+G A ++ + + + + V +++ +P P Sbjct: 458 SPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMVTLPTGPA 517 Query: 508 SFTFWPFNQE 517 + N E Sbjct: 518 KIIWEKRNPE 527 >5FSA-A nrPDB Length = 490 Score = 220 bits (561), Expect = 9e-58, Method: Composition-based stats. Identities = 85/492 (17%), Positives = 176/492 (35%), Gaps = 59/492 (11%) Query: 58 GWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPN 117 W + + QKYG ++ L + P+ +F N Sbjct: 14 PWFGSAASYGQQPYE----FFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVF-----N 64 Query: 118 PERFLIPPWVAYHQYYQRPIGVLLKKSAAWKK--DRVALNQEVMAPEATKNFLPLL-DAV 174 + + AY G + + ++ + + ++ K ++P + + + Sbjct: 65 AKLSDVSAEEAYKHLTTPVFGTGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEI 124 Query: 175 SRDFVSVLHRRIKKAGSGNYSG-DISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRF 233 FV+ ++K+ G + ++ F + +FG+ + + + F Sbjct: 125 LNYFVTDESFKLKEKTHGVANVMKTQPEITIFT---ASRSLFGDEMRRIFD------RSF 175 Query: 234 IDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGS 293 + P+ + P+L W+ A + R Sbjct: 176 AQLYSDLDKGFTPINFVFPNL---PLPHYWR---RDAAQKKISATYMKEIKLRRERGDID 229 Query: 294 VHHDYRG--ILYRLLGDS-KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQD 350 + D +++ D KM+ ++I + +L GG T++ T W L + +QD Sbjct: 230 PNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQD 289 Query: 351 MLRAEVLAARHQAQGDMATM----LQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLR- 405 ++ EV+ + GD+ + LQ +P + +IKETLR+H ++ R + N L + Sbjct: 290 VIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPE 349 Query: 406 -DYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNIT---------------- 448 +Y++P V V+ +F +PE+FDPTRW + Sbjct: 350 TNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGK 409 Query: 449 -----YFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTF-NLILM 502 L FG G +C+G + A +++ L + N R I + +++++ Sbjct: 410 VSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVL 469 Query: 503 PEKPISFTFWPF 514 P +P + Sbjct: 470 PTEPAEIIWEKR 481 >5JLC-A nrPDB Length = 515 Score = 220 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 91/494 (18%), Positives = 176/494 (35%), Gaps = 62/494 (12%) Query: 58 GWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPN 117 W+ + +KYG I+ L + P+ +F N Sbjct: 46 PWVGSAIPYGTKPYEFFED----CQKKYGDIFSFMLLGRIMTVYLGPKGHEFIF-----N 96 Query: 118 PERFLIPPWVAYHQYYQRPIGVLLKKSAAWKK--DRVALNQEVMAPEATKNFLPLL-DAV 174 + + AY G + + ++ + + EA ++PL+ + + Sbjct: 97 AKLADVSAEAAYSHLTTPVFGKGVIYDCPNHRLMEQKKFVKGALTKEAFVRYVPLIAEEI 156 Query: 175 SRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFI 234 + F + + +I + SG D+ + + + G+ + F Sbjct: 157 YKYFRNSKNFKINENNSG--IVDVMVSQPEMTIFTASRSLLGKEMRDKLDT------DFA 208 Query: 235 DAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSV 294 + P+ + P+L +H D + E R+K + Sbjct: 209 YLYSDLDKGFTPINFVFPNL--------PLEHYRKRDHAQQAISGTYMSLIKERREKNDI 260 Query: 295 HHDYRGILYRLLGDS------KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKV 348 + R ++ L+ +S KM+ ++I + +L GG T++ T W L +A V Sbjct: 261 QN--RDLIDELMKNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDV 318 Query: 349 QDMLRAEVLAARHQAQGDMA-TMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD- 406 Q+ L E + + ++ LQ +PLL IKETLRLH +L R ++ D+ + + Sbjct: 319 QEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLFRKVMRDVAIPNT 378 Query: 407 -YMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITY---------------- 449 Y++P V V+ + FF P F+ RW + + Sbjct: 379 SYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKG 438 Query: 450 --FRNLGFGWGVRQCLGRRIAELE----MTIFLINMLENFRVEIQHLSDVGTTFNLILMP 503 L FG G +C+G A + M+IF+ M + E + + T +++ +P Sbjct: 439 VSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTEGETVPPSDFT-SMVTLP 497 Query: 504 EKPISFTFWPFNQE 517 P + + E Sbjct: 498 TAPAKIYWEKRHPE 511 >2W0A-A nrPDB Length = 455 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 79/464 (17%), Positives = 163/464 (35%), Gaps = 43/464 (9%) Query: 67 RETGTHKVHLHHVQNF-----------QKYGPIYREKLGNVESVYVIDPEDVALLFKSEG 115 R +G H H H + + G + +L + V + F++ Sbjct: 8 RVSGGHDEHGHLEEFRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHANEFFFRAGD 67 Query: 116 PNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVS 175 + ++ P + G + A+ ++ + L+ + E K ++ Sbjct: 68 DDLDQAKAYP------FMTPIFGEAVVFDASPERRKEMLHNAALRGEQMKGHAATIE--- 118 Query: 176 RDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFID 235 + R I G D+ D + + + G++ + RF Sbjct: 119 ----DQVRRMIADWGEAG-EIDLLDFFAELTIYTSSACLIGKKFRDQLDG------RFAK 167 Query: 236 AIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVH 295 +++ + P+ + P L + A ++ ADI K Sbjct: 168 LYHELERGTDPLAYVDPYL---PIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDR- 223 Query: 296 HDYRGILYRLLGDS---KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDML 352 D +L + ++ + S ++I M+ G T+S T W L E+ R+ + Sbjct: 224 -DMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAV 282 Query: 353 RAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAK 412 E+ + L+ +P L+ +KETLRLHP + L R + ++ + I Sbjct: 283 IDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEG 342 Query: 413 TLVQVAIYALGREPTFFFDPENFDPTRWLSK--DKNITYFRNLGFGWGVRQCLGRRIAEL 470 LV + R P F DP +F P R+ + + + + FG G +C+G A + Sbjct: 343 DLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIM 402 Query: 471 EMTIFLINMLENFRVEI-QHLSDVGTTFN-LILMPEKPISFTFW 512 ++ +L + E+ Q + +++ +P + + Sbjct: 403 QIKAIFSVLLREYEFEMAQPPESYRNDHSKMVVQLAQPAAVRYR 446 >3EJB-B nrPDB Length = 404 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 68/396 (17%), Positives = 133/396 (33%), Gaps = 58/396 (14%) Query: 87 PIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAA 146 PIY+ YV E+ A + K L Y ++L ++ Sbjct: 27 PIYKGSFLKYPGWYVTGYEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQP 86 Query: 147 WKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFA 206 + L P T+++ P + +H + + ISD F A Sbjct: 87 DHRRLRTLASGAFTPRTTESYQPYII-------ETVHHLLDQVQGKKKMEVISDFAFPLA 139 Query: 207 FESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDH 266 I N+I PE R + + + + + ++ R + + Sbjct: 140 SFVIANII-----------GVPEEDR--EQLKEWAASLIQTIDFTRS-----RKALTEGN 181 Query: 267 VAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAG 326 + A + ++ ++K D +L + K++ E+ + + Sbjct: 182 IMAVQAMAYFKELI-------QKRKRHPQQDMISMLLKGREKDKLTEEEAASTCILLAIA 234 Query: 327 GVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLR 386 G +TT + + + ++ + LR + L+ +++E LR Sbjct: 235 GHETTVNLISNSVLCLLQHPEQLLKLR------------------ENPDLIGTAVEECLR 276 Query: 387 LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKN 446 + R D+ + I V + + A R+P+ F +P+ FD TR + Sbjct: 277 YESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP--- 333 Query: 447 ITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLEN 482 +L FG G CLG +A LE I + +L+ Sbjct: 334 -----HLSFGHGHHVCLGSSLARLEAQIAINTLLQR 364 >5VWS-A nrPDB Length = 393 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 76/424 (17%), Positives = 140/424 (33%), Gaps = 91/424 (21%) Query: 87 PIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAA 146 P++R++ G D + +++ + R + P + G+ + Sbjct: 32 PVWRDQFGIYHVFRYDDVRQILGDYQTFSSDRTRLM-PTAQGF-----GKGGITMIDPPE 85 Query: 147 WKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFA 206 + R + P++ P + ++ + L Sbjct: 86 HRHQRRLITH-AFTPQSISAMEPRIRQIADHLLDELP----------------------- 121 Query: 207 FESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDH 266 G ++E P I +L +PP LFRT W D Sbjct: 122 ---------GPEFDLVEHFAYPLPVIVI----------AELLGVPPGDRHLFRT--WSDR 160 Query: 267 VAAWDV---------IFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLG----DSKMSF 313 + + V A + N Y + H +L RL+ ++ Sbjct: 161 LMSLQVENYADPELARTVAAAMTEMNDYLREHCRSRRTHPRDDLLTRLVQAEVEGKRLDL 220 Query: 314 EDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQL 373 E++ + +L G TT++ + + + + + + +RA+ Sbjct: 221 EEVVNTASLLLLAGHLTTTVLIGNTMLCLWDHPEAEKAVRAD------------------ 262 Query: 374 VPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPE 433 L+ A+++E+LRL + R D+ + IPA V I + + F DPE Sbjct: 263 PSLIPAALEESLRLRSPFLQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPE 322 Query: 434 NFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDV 493 FD R + ++ FG GV CLG ++ LE I L +L F EI Sbjct: 323 RFDLHRQTTG--------HIAFGHGVHFCLGAQLGRLEGRIALERLLGRF-TEIHPWPRE 373 Query: 494 GTTF 497 G +F Sbjct: 374 GISF 377 >6CR2-A nrPDB Length = 477 Score = 198 bits (504), Expect = 4e-51, Method: Composition-based stats. Identities = 67/453 (14%), Positives = 141/453 (31%), Gaps = 39/453 (8%) Query: 80 QNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGV 139 KYG I+ L ++ + + + + + + Y G Sbjct: 32 DCRAKYGDIFTFILLGKKTTVYLGTKGNDFILNGKLRDVCAEEV-----YSPLTTPVFGR 86 Query: 140 LLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDIS 199 + ++ ++ + T + L + D V + D+ Sbjct: 87 HVVYDCP--NAKLMEQKKFVKYGLTSDALRSYVPLITDEVESFVKNSPAFQGHKGVFDVC 144 Query: 200 DDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFR 259 + + + + G+ + F + + + P+ + P Sbjct: 145 KTIAEITIYTASRSLQGKEVRSKFDST------FAELYHNLDMGFAPINFMLPWA---PL 195 Query: 260 TKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGD-SKMSFEDIKA 318 K A + + +I ++ ++ + + + + E+I Sbjct: 196 PHNRKRDAAQRKLTETYMEIIKARRQAGSKK--DSEDMVWNLMSCVYKNGTPVPDEEIAH 253 Query: 319 NVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATM-LQLVPLL 377 + +L G ++S T W + +A + + L E + + LQ + L Sbjct: 254 MMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLH 313 Query: 378 KASIKETLRLHPISVTLQRYLVNDLVLRD--YMIPAKTLVQVAIYALGREPTFFFDPENF 435 IKETLRLH ++ R + N + + Y+IP V + R F +P + Sbjct: 314 AKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEW 373 Query: 436 DPTRWLSKDK-----------------NITYFRNLGFGWGVRQCLGRRIAELEMTIFLIN 478 +P RW T L FG G +C+G + A L++ Sbjct: 374 NPHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITAV 433 Query: 479 MLENFRVEIQHLSDVGTTFNLILMPEKPISFTF 511 ++ FR D + + KP+ +F Sbjct: 434 LVRLFRFRNLPGVDGIPDTDYSSLFSKPLGRSF 466 >3S79-A nrPDB Length = 503 Score = 197 bits (501), Expect = 8e-51, Method: Composition-based stats. Identities = 86/443 (19%), Positives = 167/443 (37%), Gaps = 35/443 (7%) Query: 85 YGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKS 144 YG R + E++ + + + RF + G++ + Sbjct: 81 YGEFMRVWISGEETLIISKSSSMFHI-MKHNHYSSRFGSK--LGLQCIGMHEKGIIFNNN 137 Query: 145 AA-WKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLF 203 WK R + + P L + V + + R+++ + + D+ L Sbjct: 138 PELWKTTRPFFMKALSGPG-----LVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR 192 Query: 204 RFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLF---RLFRT 260 R ++ + R + E + + Q + DA L + PD+F Sbjct: 193 RVMLDTSNTLFL--RIPLDESAIVVKIQGYFDAW--------QALLIKPDIFFKISWLYK 242 Query: 261 KTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANV 320 K K D I + E + + + IL GD ++ E++ + Sbjct: 243 KYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD--LTRENVNQCI 300 Query: 321 TEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKAS 380 EML DT S++L + L+ +A++ V++ + E+ + +Q + +++ Sbjct: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDI-KIDDIQKLKVMENF 359 Query: 381 IKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRW 440 I E++R P+ + R + D V+ Y + T + + I + R FF P F + Sbjct: 360 IYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENF 418 Query: 441 LSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEI---QHLSDVGTTF 497 KN+ Y FG+G R C G+ IA + M L+ +L F V+ Q + + Sbjct: 419 ---AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIH 475 Query: 498 NLILMPEKP---ISFTFWPFNQE 517 +L L P++ + F P N + Sbjct: 476 DLSLHPDETKNMLEMIFTPRNSD 498 >4RM4-A nrPDB Length = 396 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 59/352 (16%), Positives = 117/352 (33%), Gaps = 58/352 (16%) Query: 145 AAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFR 204 K R +N + P K + P + ++ + + G D+ D Sbjct: 87 PKHTKIRSVVN-KAFTPRVMKQWEPRIQEITDELIQKFQ--------GRSEFDLVHDFSY 137 Query: 205 FAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWK 264 + + + G + + + + D +L P + K Sbjct: 138 PLPVIVISELLG-----VPSAHMEQFKAWSD-----------LLVSTPKDKSE---EAEK 178 Query: 265 DHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLL-GDSKMSFEDIKANVTEM 323 + D + + E ++ D IL K+S E++ T + Sbjct: 179 AFLEERDKCEEELAAFFAGIIEE--KRNKPEQDIISILVEAEETGEKLSGEELIPFCTLL 236 Query: 324 LAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKE 383 L G +TT+ + +Y + V + LR L+ +++E Sbjct: 237 LVAGNETTTNLISNAMYSILETPGVYEELR------------------SHPELMPQAVEE 278 Query: 384 TLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSK 443 LR + L+R D + ++I +V + + R+ F P FD R + Sbjct: 279 ALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRRHPNP 338 Query: 444 DKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF-RVEIQHLSDVG 494 ++ FG G+ CLG +A LE I L +++ F +E ++ + Sbjct: 339 --------HIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIE 382 >5L94-A nrPDB Length = 410 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 68/369 (18%), Positives = 132/369 (35%), Gaps = 69/369 (18%) Query: 145 AAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFR 204 + R +N + P+A K + P + ++ + + + DI + L Sbjct: 90 PKHAEMRALVN-KAFTPKAMKAWEPKIARITNELLQEVEHL--------EDIDIVEHLSY 140 Query: 205 -FAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTW 263 I +++ V + ++F D S ++ P + R K Sbjct: 141 PLPVMVIADIL---------GVPIEDQRQFKD-------WSDIIVAGPSNNERETLEKLQ 184 Query: 264 KDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRL-LGDSKMSFEDIKANVTE 322 ++ + A D ++ T + ++ D +L + +++ E+I Sbjct: 185 QEKMKAND------ELETYFYRIIEEKRTRPGDDIISVLLQAKEEGKQLTDEEIVGFSIL 238 Query: 323 MLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIK 382 +L G +TT+ + +Y + + + L+ E LL + I+ Sbjct: 239 LLIAGNETTTNLISNTIYCLMEDKASFERLKRE------------------KELLPSGIE 280 Query: 383 ETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLS 442 E LR L R + D+ L + A V + + R+ +F DPE F R + Sbjct: 281 EVLRYRSPVQALHRIVKEDVTLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDRKPN 340 Query: 443 KDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILM 502 ++ FG G+ CLG +A +E I L +++ + D +F L Sbjct: 341 --------VHMAFGRGIHFCLGAPLARIEAKIMLAELIDRY-----PQMDWSPSFEL--- 384 Query: 503 PEKPISFTF 511 KPI TF Sbjct: 385 --KPIESTF 391 >3RWL-A nrPDB Length = 426 Score = 191 bits (486), Expect = 5e-49, Method: Composition-based stats. Identities = 58/287 (20%), Positives = 107/287 (37%), Gaps = 45/287 (15%) Query: 221 MLEEVVNPEAQRFID--AIYQMFHTSVPMLNLPPDLFRLFRTKTWKDH---------VAA 269 L+ + E ++D +I + + P + R W D V + Sbjct: 149 TLDGLPVGEEFDWVDRVSIEITTQMLATLFDFPFEERRKLTR--WSDVTTAAPGGGVVES 206 Query: 270 WDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSK----MSFEDIKANVTEMLA 325 WD K ++ Y+++ V+ D L +L S M+ E+ NV ++ Sbjct: 207 WD--QRKTELLECAAYFQVLWNERVNKDPGNDLISMLAHSPATRNMTPEEYLGNVLLLIV 264 Query: 326 GGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETL 385 GG DTT ++ + + +N L+A L++ + E + Sbjct: 265 GGNDTTRNSMTGGVLALHKNPDQFAKLKA------------------NPALVETMVPEII 306 Query: 386 RLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDK 445 R ++R + D L I V + Y+ R+ PE F R Sbjct: 307 RWQTPLAHMRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDR------ 360 Query: 446 NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF-RVEIQHLS 491 ++L FG+G+ +C+G R+AE+++ I +L F R+E+ Sbjct: 361 -PRPRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFSRIEVMAEP 406 >4KPA-A nrPDB Length = 494 Score = 191 bits (485), Expect = 7e-49, Method: Composition-based stats. Identities = 85/479 (17%), Positives = 159/479 (33%), Gaps = 30/479 (6%) Query: 32 VPTGEGAGISTRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYRE 91 +PT E + + E+P P G L T K ++ + G I++ Sbjct: 12 IPTTE--NLYFQGAMTIKEMPQPKTFGELKNLPLLN---TDKPVQALMKIADELGEIFKF 66 Query: 92 KLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDR 151 + + Y+ + + ++ L + + WKK Sbjct: 67 EAPGRVTRYLSSQRLIKE--ACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAH 124 Query: 152 VALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESIT 211 L + +A K + ++ ++ V R + + ++ +D+ R ++I Sbjct: 125 NILLPS-FSQQAMKGYHAMMVDIAVQLVQKWERL-----NADEHIEVPEDMTRLTLDTIG 178 Query: 212 NVIFGERQGMLEEVVNPEAQRFIDA-IYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAW 270 F R + FI + + + + PD + ++ + Sbjct: 179 LCGFNYR---FNSFYRDQPHPFITSMVRALDEAMNKLQRANPDD------PAYDENKRQF 229 Query: 271 DVIFSKADIYTQNFYWELRQKGSVHHDYRGILY---RLLGDSKMSFEDIKANVTEMLAGG 327 + + + G D + + E+I+ + L G Sbjct: 230 QEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAG 289 Query: 328 VDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRL 387 +TTS L + LY + +N V E ++ + + + E LRL Sbjct: 290 HETTSGLLSFALYFLVKNPHVLQKAAEEAARVL-VDPVPSYKQVKQLKYVGMVLNEALRL 348 Query: 388 HPISVTLQRYLVNDLVLRD-YMIPAKTLVQVAIYALGREPTFF-FDPENFDPTRWLSKDK 445 P + Y D VL Y + + V I L R+ T + D E F P R+ + Sbjct: 349 WPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSA 408 Query: 446 NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPE 504 I FG G R C+G++ A E T+ L ML++F E ++ L L PE Sbjct: 409 -IPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPE 466 >4JBT-A nrPDB Length = 410 Score = 191 bits (485), Expect = 7e-49, Method: Composition-based stats. Identities = 73/439 (16%), Positives = 147/439 (33%), Gaps = 74/439 (16%) Query: 79 VQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPI- 137 + GP+ R L V ++ V L + W + Q P+ Sbjct: 23 TSRLRAAGPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDINAWSLWQSGTVTRQWPLI 82 Query: 138 -------GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAG 190 + ++ R+ + + P + +V+ L +++AG Sbjct: 83 GMIDVDRSMFTVDGPEHRRLRIK-TTQALTRRRLDALKPTI----ERYVAELLDDLERAG 137 Query: 191 SGNYSGDISDDLFR-FAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLN 249 + D+ I+ ++ V + + ++ + F P Sbjct: 138 ADGAVVDLKSVFAYPLPMRVISALM---------GVPSEDQEQLLTWYKAFFSILTP--- 185 Query: 250 LPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRG-ILYRLLGD 308 VI +T+ R+ D ++Y G+ Sbjct: 186 ----------------QDERLRVIDEMHGYFTEMV---RRKTAEPGDDLTSALIYATDGE 226 Query: 309 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMA 368 + ++ E++ N+ ++A G +TT + + + + + ++R + Sbjct: 227 TPLTEEEVIGNLQALVAAGHETTVSLILTAVRALLSHPEQLRLVRDGEIG---------- 276 Query: 369 TMLQLVPLLKASIKETLRLH-PISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPT 427 + +I+ETLR P+ L R+ D+ L D +IP V ++ A+GR+ T Sbjct: 277 --------WETAIEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDIT 328 Query: 428 FF-FDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVE 486 D ++FD TR T R++ FG G C G +A LE I L + F Sbjct: 329 VHGADADDFDITR-------ATAARHISFGHGPHICPGAALARLEAAIALPALFTRFP-H 380 Query: 487 IQHLSDVGTTFNLILMPEK 505 + + NL ++ + Sbjct: 381 LHPALPLDQIPNLPVLTQN 399 >5OFQ-A nrPDB Length = 409 Score = 191 bits (485), Expect = 7e-49, Method: Composition-based stats. Identities = 43/221 (19%), Positives = 85/221 (38%), Gaps = 29/221 (13%) Query: 265 DHVAAWDVIFSKADIYTQNFYWE---LRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVT 321 + A ++ I+ Q ++ E RQ+ +L + ++ E++ Sbjct: 177 EAFAKMMQKRNEGVIFLQGYFKEIIAERQQNKQEDLISLLLEAEIDGEHLTEEEVLGFCI 236 Query: 322 EMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASI 381 +L G +TT+ + + M ++ VQ+ +R ++ L+ + Sbjct: 237 LLLVAGNETTTNLITNGVRYMTEDVDVQNEVRRDI------------------SLVPNLV 278 Query: 382 KETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWL 441 +ETLR +P + R D+ L + I V + R+ F P+ F R Sbjct: 279 EETLRYYPPIQAIGRIAAEDVELGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHRKT 338 Query: 442 SKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLEN 482 + ++ FG+G+ CLG +A +E I +LE Sbjct: 339 NP--------HVSFGFGIHFCLGAPLARMEGKIAFTKLLEK 371 >1UED-A nrPDB Length = 406 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 53/281 (18%), Positives = 102/281 (36%), Gaps = 31/281 (11%) Query: 207 FESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDH 266 E + +R +LE + + A H +L +P D R F + ++ Sbjct: 124 MEPAIQSLIDDRLDLLEAEGPSADLQGLFADPVGAHALCELLGIPRDDQREFVRRIRRNA 183 Query: 267 VAAWDVIFSKADIYTQNFYWE---LRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEM 323 + + AD N Y + RQ+ G++ R GD+ ++ E++K T + Sbjct: 184 DLSRGLKARAADSAAFNRYLDNLLARQRADPDDGLLGMIVRDHGDN-VTDEELKGLCTAL 242 Query: 324 LAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKE 383 + GGV+T + + + + + N ++L + + + E Sbjct: 243 ILGGVETVAGMIGFGVLALLDNPGQIELL------------------FESPEKAERVVNE 284 Query: 384 TLRLHPISVTL-QRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLS 442 +R R + D+V+ +I A V +I R+ DP+ D R Sbjct: 285 LVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPDVLDANRAAV 344 Query: 443 KDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 D +GFG G+ C+G +A + + + F Sbjct: 345 SD--------VGFGHGIHYCVGAALARSMLRMAYQTLWRRF 377 >2ZBZ-A nrPDB Length = 412 Score = 187 bits (475), Expect = 8e-48, Method: Composition-based stats. Identities = 70/428 (16%), Positives = 138/428 (32%), Gaps = 75/428 (17%) Query: 86 GPIYREKLG-NVESVYVIDPEDVALLF---KSEGPNPERFLIPPWVAYHQYYQRPIGVLL 141 GP++R L ++ V E L + + A+ + P + Sbjct: 38 GPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPAFEAVRESPQAFIG 97 Query: 142 KKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDD 201 R + + K P ++ V F+ + + + D+ Sbjct: 98 LDPPEH-GTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEML-------AAGPTADLVSQ 149 Query: 202 LFRFAFE-SITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRT 260 I ++ V + + F DA RL ++ Sbjct: 150 FALPVPSMVICRLL---------GVPYADHEFFQDASK-----------------RLVQS 183 Query: 261 KTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANV 320 + + A + + D F Q ++ L + ++ E++ + Sbjct: 184 TDAQSALTARNDLAGYLDGLITQF-----QTEPGAGLVGALVADQLANGEIDREELISTA 238 Query: 321 TEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKAS 380 +L G +TT+ + + + + LRA+ L+ + Sbjct: 239 MLLLIAGHETTASMTSLSVITLLDHPEQYAALRADR------------------SLVPGA 280 Query: 381 IKETLRLHPIS-VTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTR 439 ++E LR I+ + R D+ + +I A V V R+ T + DP+ D R Sbjct: 281 VEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTVYEDPDALDIHR 340 Query: 440 WLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNL 499 + +L FG+GV QCLG+ +A LE+ + L +++ + L L Sbjct: 341 --------SARHHLAFGFGVHQCLGQNLARLELEVILNALMDR----VPTLRLAVPVEQL 388 Query: 500 ILMPEKPI 507 +L P I Sbjct: 389 VLRPGTTI 396 >4Z5P-A nrPDB Length = 400 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 67/339 (19%), Positives = 128/339 (37%), Gaps = 52/339 (15%) Query: 179 VSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIY 238 + L + A ++LF + + ER G ++V AQ F A+ Sbjct: 97 LRRLLSKAFTARRMGAMQSWLEELFAGLLDGV------ERTGHPADIVRDLAQPFTIAV- 149 Query: 239 QMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAW----DVIFSKADIYTQNFYWEL--RQKG 292 +L +P + R + W + + + AD + + +L ++ Sbjct: 150 -----ICRLLGVPYEDR--GRFQHWSEVIMSTTAYSKEEAVSADASIRAYLADLVSARRA 202 Query: 293 SVHHDYRGILYRLLGDS-KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDM 351 + H D G+L D +++ +++ +L G +T++ L +Y + + + Sbjct: 203 APHDDLLGVLVSARDDDDRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSL 262 Query: 352 LRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTL--QRYLVNDLVLRDYMI 409 LR + LL +++E LR P+ + R + D+ L + Sbjct: 263 LR------------------EQPELLPRAVEELLRFVPLGNGVGNARIALEDVELSGGTV 304 Query: 410 PAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAE 469 A V A R+P F DP+ D TR + +L FG G CLG ++A Sbjct: 305 RAGEGVVAAAVNANRDPRAFDDPDRLDITREKNP--------HLAFGHGAHYCLGAQLAR 356 Query: 470 LEMTIFLINMLENF---RVEIQHLSDVGTTFNLILMPEK 505 +E+ + + +LE F R+ + T L P++ Sbjct: 357 MELRVAIGGLLERFPGLRLAVPADQVEWKTGGLFRGPQR 395 >4GGV-A nrPDB Length = 418 Score = 184 bits (468), Expect = 6e-47, Method: Composition-based stats. Identities = 66/366 (18%), Positives = 130/366 (35%), Gaps = 53/366 (14%) Query: 138 GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGD 197 G + + + L P + + ++R+ + + G + Sbjct: 93 GDMSQMDPPRHRKYRQLVSRAFTPRLVADMETRVADITRELLDAV--------DGKPEIE 144 Query: 198 ISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRL 257 I+ DL + + G G + +++ D I + F F Sbjct: 145 IAADLAYPLPVIVIAELLGVPAGDRD-----LFKKWADDIIEGFSGF---------SFLD 190 Query: 258 FRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIK 317 + +D A + + D + R++ ++ + +++ +I Sbjct: 191 TSGQGEQDVRDATERLRPLLDYMAGHVTE--RRRTPREDLLTHLVQAEVDGERLTDNEIV 248 Query: 318 ANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLL 377 +L G TT+MTL + + + +V +RA+ L+ Sbjct: 249 NVANILLVTGHITTTMTLGNTVLCLDADPEVAAKVRADR------------------SLV 290 Query: 378 KASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDP 437 +I+E LR+ S L R ++ + +IP +V + + A R+P F DPE +DP Sbjct: 291 PGAIEEALRVLSPSAALARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDP 350 Query: 438 TRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF---RVEIQHLSDVG 494 TR + + GFG G+ CLG +A LE + L + + F R + Sbjct: 351 TRDPNP--------HFGFGRGIHFCLGAPLARLEGRVALNALFDRFPVLRTDPAKPPTFF 402 Query: 495 TTFNLI 500 T ++I Sbjct: 403 PTPDMI 408 >6HQW-A nrPDB Length = 445 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 62/329 (18%), Positives = 122/329 (37%), Gaps = 48/329 (14%) Query: 165 KNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEE 224 + LP+ A+ R + R + A + ++ ++ R + ++ +GER +++ Sbjct: 123 ERQLPMFIAMDRPDHTGQRRTVAPAFTPAKMVEMEAEIRRRTASVLDSLPWGERFDWVDK 182 Query: 225 VVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKD---------HVAAWDVIF- 274 V I+ M + P RL W D D F Sbjct: 183 VS-------IELTTGMLAI---LFGFPWADRRLLT--FWSDWAGDVELTLARELADTRFG 230 Query: 275 SKADIY-TQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSM 333 ++ W R + D ++ + MS ++ N+ ++ GG DTT Sbjct: 231 FLGEMAHYFQRLWGARMQAPPSGDLISMMIHSEAMNHMSPQEFMGNLVLLIVGGNDTTRN 290 Query: 334 TLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVT 393 T+ ++ + + +++L + L+ +++E +R Sbjct: 291 TMSGIVHALDKFPDQRELLERD------------------ASLIPNAVQECIRYVTPLAH 332 Query: 394 LQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNL 453 ++R D L I A V + + R+ T F +P+ R ++ R+L Sbjct: 333 MRRTATADTELFGNQIKAGEKVILWYISANRDETVFENPDKLMVDRPNAR-------RHL 385 Query: 454 GFGWGVRQCLGRRIAELEMTIFLINMLEN 482 FG G+ +C+G R+AEL++ I L M E Sbjct: 386 SFGHGIHRCVGARLAELQLRILLEEMHER 414 >4UBS-A nrPDB Length = 393 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 75/429 (17%), Positives = 142/429 (33%), Gaps = 80/429 (18%) Query: 87 PIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVA----YHQYYQRPIGVLLK 142 P+ R L + SV+V+ A S+ +P + A + R + +L Sbjct: 27 PLSRVSLYDGRSVWVVTGHAAARALLSDQRLSSDRTLPRFPATTERFEAVRTRRVALLGV 86 Query: 143 KSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDL 202 + R ++ P T L ++ V L ++ G + + Sbjct: 87 DDPEHRTQRR-----MLVPSFTLKRAAALRPRIQETVDGLLDAMEAQGPPA------ELV 135 Query: 203 FRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKT 262 FA + VI +L +P F +++ Sbjct: 136 SAFALPLPSMVI------------------------------CALLGVPYADHDFFESQS 165 Query: 263 WK----DHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKA 318 + +A ++ D Y + ++K ++ L + ++ + Sbjct: 166 RRLLRGPGIAEVQDARAQLDDYLYA-LIDRKRKEPGDGLLDDLIQEQLNRGTVDRAELVS 224 Query: 319 NVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLK 378 T +L G +TT+ + + + R+ + LRAE L+ Sbjct: 225 LATLLLIAGHETTANMISLGTFTLLRHPEQLAELRAE------------------PGLMP 266 Query: 379 ASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPT 438 A+++E LR I+ L R D+ + I A V A + R+ F +P+ D Sbjct: 267 AAVEELLRFLSIADGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWH 326 Query: 439 RWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFN 498 R + ++ FG+G+ QCLG+ +A EM I L + E + L Sbjct: 327 R--------SARHHVAFGFGIHQCLGQNLARAEMEIALGTLFER----LPGLRLAAPADE 374 Query: 499 LILMPEKPI 507 + P I Sbjct: 375 IPFKPGDTI 383 >5EX6-C nrPDB Length = 434 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 53/271 (19%), Positives = 96/271 (35%), Gaps = 31/271 (11%) Query: 217 ERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSK 276 ER +E +P + A +L +P D +F + A+ Sbjct: 161 ERLDEMEREGSPADLIELFADEVPGPVLCELLGVPRDDRAMFLQLCHRHLDASLSGRRRA 220 Query: 277 ADIYTQNFYWE---LRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSM 333 A + Y R++ G++ GD+ ++ E+++ +M+ G D S Sbjct: 221 AAGEAFSRYLVTMVARERKDPGDGLIGMVVAEHGDT-VTDEELRGVCVQMMLAGDDNISG 279 Query: 334 TLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVT 393 + + + RN + LR +V P + ++ E +R + Sbjct: 280 MIGLGVLALLRNPEQIAALRGDV------------------PAAERAVDELIRYLTVPYA 321 Query: 394 -LQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRN 452 R + D + D +I A V ++ R+P D + D TR + Sbjct: 322 PTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADRLDVTR--------EAVPH 373 Query: 453 LGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 + FG GV CLG +A LE+ I + F Sbjct: 374 VAFGHGVHHCLGAALARLELRIAYTALWRRF 404 >5CJE-A nrPDB Length = 393 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 51/245 (20%), Positives = 92/245 (37%), Gaps = 32/245 (13%) Query: 244 SVPMLNLPPDLFRLFRTKTWKDHVAA---WDVIFSKADIYTQNFYWELRQKGSVHHDYRG 300 +L +P FR + + ++ + + + ++ + D G Sbjct: 146 ICELLGVPDIDRVTFRALSNEIVAPTGGDAELAAYERLAAYLDELIDDKRSTAPADDLLG 205 Query: 301 ILYR--LLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLA 358 L R D ++S E+++A +L G +TT + ++ + + LRA+ Sbjct: 206 DLIRTRAEDDDRLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRAD--- 262 Query: 359 ARHQAQGDMATMLQLVPLLKASIKETLRLH-PISVTLQRYLVNDLVLRDYMIPAKTLVQV 417 + LL +++E LR P+ RY + + I V + Sbjct: 263 ---------------MTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPVMI 307 Query: 418 AIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLI 477 + A GR+P DP FD R +L FG G+ CLG +A LE + L Sbjct: 308 GLDAAGRDPARHPDPHVFDIHRAPQG--------HLAFGHGIHYCLGAPLARLEARVALR 359 Query: 478 NMLEN 482 ++LE Sbjct: 360 SLLER 364 >2VZM-A nrPDB Length = 436 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 55/244 (22%), Positives = 89/244 (36%), Gaps = 35/244 (14%) Query: 246 PMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKA-DIYTQNFYWELRQKGSVHHDYRGILYR 304 +L +P FR W D D + + Y D +L Sbjct: 179 ELLGVPEPDRAAFR--VWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSA 236 Query: 305 LL-----GDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAA 359 L+ S+++ E++ +L G +TT + +Y + + LRA+ Sbjct: 237 LVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRAD---- 292 Query: 360 RHQAQGDMATMLQLVPLLKASIKETLRLH-PISVTLQRYLVNDLVLRDYMIPAKTLVQVA 418 + LL +++E LR P+ R+ V + L +IPA V V Sbjct: 293 --------------MTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVV 338 Query: 419 IYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLIN 478 + R P F DP FD R + +L FG G+ C+G +A LE I + Sbjct: 339 LADAHRTPERFPDPHRFDIRRDTAG--------HLAFGHGIHFCIGAPLARLEARIAVRA 390 Query: 479 MLEN 482 +LE Sbjct: 391 LLER 394 >3R9C-A nrPDB Length = 418 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 89/460 (19%), Positives = 145/460 (31%), Gaps = 71/460 (15%) Query: 57 NGWLNLYHFWRE-TGTHKVHLHHVQNFQKYGPIY-REKLGNV------ESVYVIDPEDVA 108 NGW++ +E G L Y PIY R + G D Sbjct: 3 NGWMSTAATAQEAQGLLLQLLDPATRADPY-PIYDRIRRGGPLALPEANLAVFSSFSDCD 61 Query: 109 LLFKSEGPNPERF----LIPPWVAYHQ-YYQRPIGVLLKKSAAWKKDRVALNQEVMAPEA 163 + + +R A Q Q P L + R L + AP Sbjct: 62 DVLRHPSSCSDRTKSTIFQRQLAAETQPRPQGPASFLFLDPPDHTRLRG-LVSKAFAPRV 120 Query: 164 TKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFR-FAFESITNVIFGERQGML 222 K P + A+ + + ++ D+L I ++ Sbjct: 121 IKRLEPEITALVDQLLDAVD---------GPEFNLIDNLAYPLPVAVICRLL-------- 163 Query: 223 EEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQ 282 V + +F A + P L L + LF + + Sbjct: 164 -GVPIEDEPKFSRASALLAAALDPFLALTGETSDLFDEQMKAGMWLRDYLRA-------- 214 Query: 283 NFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEM 342 + R++ G++ +++ ++I A +L G +TT + M Sbjct: 215 --LIDERRRTPGEDLMSGLVAVEESGDQLTEDEIIATCNLLLIAGHETTVNLIANAALAM 272 Query: 343 ARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDL 402 R L A+ A A I+ET+R P + RY +DL Sbjct: 273 LRTPGQWAALAADGSRA------------------SAVIEETMRYDPPVQLVSRYAGDDL 314 Query: 403 VLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQC 462 + + +P + + + A R+PT P+ FDP R R+LGFG G C Sbjct: 315 TIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPDR--------AQIRHLGFGKGAHFC 366 Query: 463 LGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILM 502 LG +A LE T+ L + F E + + NL L Sbjct: 367 LGAPLARLEATVALPALAARFP-EARLSGEPEYKRNLTLR 405 >5XW2-A nrPDB Length = 419 Score = 179 bits (453), Expect = 3e-45, Method: Composition-based stats. Identities = 56/378 (14%), Positives = 126/378 (33%), Gaps = 55/378 (14%) Query: 138 GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGD 197 G LL+ ++ L P+ P + A++++ + + R Sbjct: 92 GDLLQTDPPDHRELRKLVSHAFTPKVVAELEPRITALTQELLDAVADRD----------- 140 Query: 198 ISDDLFRFAFESITNVIFGERQGMLEEVVN-PEAQRFIDAIYQMFHTSVPMLNLPPDLFR 256 F+ +T + + ++ E+++ P A R V L Sbjct: 141 --------TFDLMTALAYPLPVTVVAELLSIPSADR--HLFEGWMTEIVHSL----GDVS 186 Query: 257 LFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDI 316 + ++ + + + + + ++ ++ + +++ I Sbjct: 187 MEDAPEDQERIFEAGMAPMRKMLEYLREHAAECRRRPRGDLMGKLIEAEVDGRRLTDNHI 246 Query: 317 KANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPL 376 +L G TT+M + + + + +RA+ L Sbjct: 247 VNFAKMLLIAGYLTTTMLIGNTVLCLDSYPEQAARVRADR------------------SL 288 Query: 377 LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFD 436 + ++E++R R D+ + + A +V V A R+ F +PE FD Sbjct: 289 IPGLLEESMRFLSPVAATYRATTRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPELFD 348 Query: 437 PTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFR---VEIQHLSDV 493 TR + +LGFG G+ CLG +A +E + L ++L+ F + + Sbjct: 349 MTRGPNP--------HLGFGRGIHFCLGGPLARMEGRVALDHLLDRFPELYTDPERPPTF 400 Query: 494 GTTFNLILMPEKPISFTF 511 F+ + P+ + Sbjct: 401 MPGFDTTGVSSLPLRTSL 418 >2XKR-A nrPDB Length = 398 Score = 178 bits (452), Expect = 4e-45, Method: Composition-based stats. Identities = 50/273 (18%), Positives = 95/273 (34%), Gaps = 52/273 (19%) Query: 257 LFRTKTWKDHVAAW--DVIFSKADIYTQNFYW-----------------ELRQKGSVHHD 297 L +D W D++ + +Q + R+ Sbjct: 142 LGVRPEQRDMFLRWSDDLVTFLSSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDL 201 Query: 298 YRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVL 357 ++ + ++S +++ +L GG +TT TL ++ RN D+L+ + Sbjct: 202 VSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRD-- 259 Query: 358 AARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQV 417 LL +I+E LR + R L D + A + + Sbjct: 260 ----------------PSLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALCAGEKMML 303 Query: 418 AIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLI 477 + + F +PE FD R +L FG+G CLG ++A LE+++ Sbjct: 304 LFESANFDEAVFCEPEKFDVQR--------NPNSHLAFGFGTHFCLGNQLARLELSLMTE 355 Query: 478 NMLENFRVEIQHLSDVGTTFNLILMPEKPISFT 510 +L L D+ + ++P +P +F Sbjct: 356 RVLRR-------LPDLRLVADDSVLPLRPANFV 381 >5XJN-A nrPDB Length = 455 Score = 178 bits (451), Expect = 5e-45, Method: Composition-based stats. Identities = 62/378 (16%), Positives = 126/378 (33%), Gaps = 58/378 (15%) Query: 138 GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGD 197 G+ + + R A+ Q+ P K P + A+ D V + + + GD Sbjct: 134 GLSARIPPEHTRIR-AIAQKAFTPRRYKALEPDIRAMVIDRVEKML------ANDQHVGD 186 Query: 198 ISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRL 257 + DL + G M++ +R+ D+ M + P L Sbjct: 187 MVSDLAYDIPTITILTLIGADISMVDT-----YKRWSDSRAAMTWGDLSDEEQIPHAHNL 241 Query: 258 FRTKTWK-DHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDI 316 + W+ D D T ++ +++ +I Sbjct: 242 V--EYWQECQRMVADAHAHGGDNLTA-----------------DLVRAQQEGQEITDHEI 282 Query: 317 KANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPL 376 + + +L G +TT+ + + + + + L+ L Sbjct: 283 ASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAI------------------LENPKL 324 Query: 377 LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFD 436 + A++ E LR V +R + D + I V + + + R+ F + E FD Sbjct: 325 IPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFD 384 Query: 437 PTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF-RVEIQHLSDVGT 495 +R +++ +L FG+G+ CLG +A+L+ I L + + + +G Sbjct: 385 ISRANARE-------HLSFGFGIHYCLGNMLAKLQAKICLEEVTRLVPSLHLVADKAIGF 437 Query: 496 TFNLILMPEKPISFTFWP 513 NL + T+ Sbjct: 438 RENLSFRVPTSVPVTWNA 455 >5GWE-A nrPDB Length = 405 Score = 178 bits (451), Expect = 5e-45, Method: Composition-based stats. Identities = 62/378 (16%), Positives = 126/378 (33%), Gaps = 58/378 (15%) Query: 138 GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGD 197 G+ + + R A+ Q+ P K P + A+ D V + + + GD Sbjct: 84 GLSARIPPEHTRIR-AIAQKAFTPRRYKALEPDIRAMVIDRVEKML------ANDQHVGD 136 Query: 198 ISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRL 257 + DL + G M++ +R+ D+ M + P L Sbjct: 137 MVSDLAYDIPTITILTLIGADISMVDT-----YKRWSDSRAAMTWGDLSDEEQIPHAHNL 191 Query: 258 FRTKTWK-DHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDI 316 + W+ D D T ++ +++ +I Sbjct: 192 V--EYWQECQRMVADAHAHGGDNLTA-----------------DLVRAQQEGQEITDHEI 232 Query: 317 KANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPL 376 + + +L G +TT+ + + + + + L+ L Sbjct: 233 ASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAI------------------LENPKL 274 Query: 377 LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFD 436 + A++ E LR V +R + D + I V + + + R+ F + E FD Sbjct: 275 IPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFD 334 Query: 437 PTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF-RVEIQHLSDVGT 495 +R +++ +L FG+G+ CLG +A+L+ I L + + + +G Sbjct: 335 ISRANARE-------HLSFGFGIHYCLGNMLAKLQAKICLEEVTRLVPSLHLVADKAIGF 387 Query: 496 TFNLILMPEKPISFTFWP 513 NL + T+ Sbjct: 388 RENLSFRVPTSVPVTWNA 405 >4TRI-A nrPDB Length = 407 Score = 178 bits (451), Expect = 6e-45, Method: Composition-based stats. Identities = 50/231 (21%), Positives = 87/231 (37%), Gaps = 30/231 (12%) Query: 289 RQKGSVHHDYRGILY-RLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLK 347 +++ D +L + +MS ++I +L GG +TT TL ++ R+ Sbjct: 195 KRRAEPTDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRD 254 Query: 348 VQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDY 407 D L A+V LL +I+E LR + R L D V Sbjct: 255 QWDALVADVD------------------LLPGAIEEMLRWTSPVKNMCRTLTADTVFHGT 296 Query: 408 MIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRI 467 + A + + + + + F DP+NF R ++ FG+G CLG ++ Sbjct: 297 ELRAGEKIMLMFESANFDESVFGDPDNFRIDR--------NPNSHVAFGFGTHFCLGNQL 348 Query: 468 AELEMTIFLINMLENF-RVEIQHLSDVGTTF-NLILMPEKPISFTFWPFNQ 516 A LE+ + +L + + + V N + PE + F P Sbjct: 349 ARLELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPES-MPVVFTPSAP 398 >6B11-A nrPDB Length = 440 Score = 177 bits (449), Expect = 8e-45, Method: Composition-based stats. Identities = 57/283 (20%), Positives = 113/283 (39%), Gaps = 40/283 (14%) Query: 216 GERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFS 275 G+ +L + P A + I +L++P + F+ +T + A Sbjct: 176 GDEADLLADFALPMATQVI----------CRLLDIPYEDRDYFQERTEQATRPAAGEEAL 225 Query: 276 KADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSK---MSFEDIKANVTEMLAGGVDTTS 332 +A + +++ L + G+L ++ ++ +S D+ N +LA G +TT+ Sbjct: 226 EALLELRDYLDRLISGKTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTA 285 Query: 333 MTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISV 392 + + + ++ L LL ++ E LR I+ Sbjct: 286 SMVTMSVLVLLQHPTAWREL------------------TVNPGLLPGAVDELLRYLSIAD 327 Query: 393 TLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRN 452 L+R D+ + + I A + + A R+ F +PE FD R + R+ Sbjct: 328 GLRRSATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHR--------SARRH 379 Query: 453 LGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGT 495 + FG+G QCLG+ +A +E+ + L +LE ++ +DV Sbjct: 380 VAFGYGPHQCLGQNLARMELEVALGAVLERLP-ALRPTTDVAG 421 >1CPT-A nrPDB Length = 428 Score = 177 bits (449), Expect = 8e-45, Method: Composition-based stats. Identities = 52/224 (23%), Positives = 92/224 (41%), Gaps = 30/224 (13%) Query: 290 QKGSVHHDYRGILY-RLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKV 348 ++ D +L L + + + I A + G DTTS + + ++RN + Sbjct: 230 RRSCPKDDVMSLLANSKLDGNYIDDKYINAYYVAIATAGHDTTSSSSGGAIIGLSRNPEQ 289 Query: 349 QDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYM 408 + +++ L+ + E +R + R + D +R Sbjct: 290 LALAKSD------------------PALIPRLVDEAVRWTAPVKSFMRTALADTEVRGQN 331 Query: 409 IPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIA 468 I + ++ + R+ F +P+ FD TR+ + R+LGFGWG CLG+ +A Sbjct: 332 IKRGDRIMLSYPSANRDEEVFSNPDEFDITRFPN--------RHLGFGWGAHMCLGQHLA 383 Query: 469 ELEMTIFLINMLENF-RVEIQHLSDVGTTFNLILMPEK-PISFT 510 +LEM IF +L VE+ + T N + P+ PI FT Sbjct: 384 KLEMKIFFEELLPKLKSVELSGPPRLVAT-NFVGGPKNVPIRFT 426 >4YZR-A nrPDB Length = 405 Score = 177 bits (449), Expect = 9e-45, Method: Composition-based stats. Identities = 68/456 (14%), Positives = 156/456 (34%), Gaps = 76/456 (16%) Query: 69 TGTHKVHLHHVQNFQKYGPIYREKLGNVESVY----VIDPEDVALLFKSEGPNPE----- 119 H + F++ PI+R +L + Y + +D K + Sbjct: 11 KEFHHNPFSVLGRFREEEPIHRFELKRFGATYPAWLITRYDDCMAFLKDNRITRDVKNVM 70 Query: 120 -RFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDF 178 + I +L K + + R L + P +N ++ ++ Sbjct: 71 NQEQIKMLNVSEDIDFVSDHMLAKDTPDHTRLRS-LVHQAFTPRTIENLRGSIEQIAEQL 129 Query: 179 VSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIY 238 + + + N + + F I+ ++ + + + Q + +A+ Sbjct: 130 LDEMEKE-------NKADIMKSFASPLPFIVISELM------GIPKEDRSQFQIWTNAMV 176 Query: 239 QMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDY 298 + + N F+ + K D R+ Sbjct: 177 DTSEGNRELTNQALREFKDYIAKLIHD-----------------------RRIKPKDDLI 213 Query: 299 RGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLA 358 +++ SK+S +++ + + ++ G++TT L + ++ K + L+ Sbjct: 214 SKLVHAEENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLK----- 268 Query: 359 ARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQ-RYLVNDLVLRDYMIPAKTLVQV 417 Q ++ +++E LR V + R+ + D + + I ++ + Sbjct: 269 -------------QQPEMIATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFI 315 Query: 418 AIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLI 477 I + R+P FF +PE + R + R++ FG+G+ CLG +A LE I Sbjct: 316 GIGSANRDPNFFENPEILNINR--------SPNRHISFGFGIHFCLGAPLARLEGHIAFK 367 Query: 478 NMLENF-RVEIQHLS-DVGTTFNLILMPEKPISFTF 511 +L+ F +E+ D+ N+ L + + + Sbjct: 368 ALLKRFPDIELAVAPDDIQWRKNVFLRGLESLPVSL 403 >6GMF-A nrPDB Length = 397 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 37/188 (19%), Positives = 76/188 (40%), Gaps = 26/188 (13%) Query: 296 HDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAE 355 +L + K++ ++ + +L G +TT+ + L + + + +A+ Sbjct: 203 DLISQLLAAEVDGEKLTAGEVLSFANTLLIAGNETTTSLIGNALVALTDHPEQLAAAQAD 262 Query: 356 VLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLV 415 + L+ A ++E LR + + R + D+ + D IPA+++V Sbjct: 263 ------------------LSLVPAVVEEVLRYESPAQCIFRQTMTDVEIGDERIPARSVV 304 Query: 416 QVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIF 475 + + R+ + F DP+ FD R +L FG + C+G +A LE + Sbjct: 305 LPLLASANRDESRFPDPDRFDIHRDTKG--------HLAFGLDIHFCIGAPLARLEAKVM 356 Query: 476 LINMLENF 483 L +L Sbjct: 357 LEVLLARL 364 >1Z8P-A nrPDB Length = 404 Score = 176 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 60/348 (17%), Positives = 116/348 (33%), Gaps = 68/348 (19%) Query: 139 VLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDI 198 + + R ++QE + P ++ ++ + + + G DI Sbjct: 90 MGTSDPPTHTRLRKLVSQE-FTVRRVEAMRPRVEQITAELLD-------EVGDSG-VVDI 140 Query: 199 SDDLFR-FAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRL 257 D + I ++ ++E E R+ I M Sbjct: 141 VDRFAHPLPIKVICELL------GVDEKYRGEFGRWSSEILVM----------------- 177 Query: 258 FRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDS--KMSFED 315 D A + ++ R++ D L R+ D ++S ++ Sbjct: 178 -------DPERAEQRGQAAREVVNFILDLVERRRTEPGDDLLSALIRVQDDDDGRLSADE 230 Query: 316 IKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVP 375 + + +L G +++ + Y + + ++R + A Sbjct: 231 LTSIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVRRDPSA----------------- 273 Query: 376 LLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENF 435 L +++E LR T R+ ++ + IP + V VA A R+P F DP F Sbjct: 274 -LPNAVEEILRYIAPPETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRF 332 Query: 436 DPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 D TR +L FG G+ C+GR +A+LE + L + F Sbjct: 333 DVTRDTRG--------HLSFGQGIHFCMGRPLAKLEGEVALRALFGRF 372 >2FR7-A nrPDB Length = 412 Score = 175 bits (443), Expect = 5e-44, Method: Composition-based stats. Identities = 51/233 (21%), Positives = 90/233 (38%), Gaps = 28/233 (12%) Query: 282 QNFYWELRQKGSVHHDYRGILYRLLGDS-KMSFEDIKANVTEMLAGGVDTTSMTLQWHLY 340 Q + E Q+ ++ G D+ +++ E+ V +L+ G+DTT + +Y Sbjct: 206 QAYVAEQCQRPNLAPGGFGACIHAFSDTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVY 265 Query: 341 EMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVN 400 +AR LRA+ L + + +E +R T R Sbjct: 266 CLARFPDEFARLRAD------------------PSLARNAFEEAVRFESPVQTFFRTTTR 307 Query: 401 DLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVR 460 D+ L I V + + + R+P + DP+ +D TR S ++GFG GV Sbjct: 308 DVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRYDITRKTSG--------HVGFGSGVH 359 Query: 461 QCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWP 513 C+G+ +A LE + L + I+ + FN L + + P Sbjct: 360 MCVGQLVARLEGEVVLAALARKV-AAIEIAGPLKRRFNNTLRGLESLPIQLTP 411 >6A7J-A nrPDB Length = 411 Score = 174 bits (442), Expect = 6e-44, Method: Composition-based stats. Identities = 67/413 (16%), Positives = 136/413 (32%), Gaps = 80/413 (19%) Query: 86 GPIYREKL-GNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQ-----------YY 133 GP+ +L G V V ++ L + I W A+ + Sbjct: 26 GPLAEVELPGGVHVYAVTHHKEARALLTDSRVVKD---INVWNAWQRGEIPADWPLIGLV 82 Query: 134 QRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGN 193 +L ++ R L + + + + ++A++ + L Sbjct: 83 NPGRSMLTVDGPDHRRLRT-LVAQALTVKRVEKLRAGIEALTNASLERLAAL-----PAG 136 Query: 194 YSGDISDDLFR-FAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPP 252 D+ + I+ ++ ++ +P + + + F T P +P Sbjct: 137 EPVDLKAEFAYPLPMNVISELM------GVDAADHPRLK---ELFEKFFSTQTPPEEVP- 186 Query: 253 DLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMS 312 D+ I E ++ ++ ++ Sbjct: 187 --------------QMMADLGTLFTKIV------EEKKANPGDDLTSALIAASEDGDHLT 226 Query: 313 FEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQ 372 E+I + ++A G +TT + + +A + + + + + Sbjct: 227 DEEILNTLQLIIAAGHETTISLIVNVVEALAIHPEQRKKV-----------------LSG 269 Query: 373 LVPLLKASIKETLRL-HPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFF-F 430 +P + I+ETLR P S L R+ D+ + D ++P + V+ ALGR+ + Sbjct: 270 EIP-WEGVIEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGP 328 Query: 431 DPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 +FD TR T R++ FG G C G ++ LE I L + E F Sbjct: 329 TAGDFDATR--------TPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERF 373 >6HQG-A nrPDB Length = 425 Score = 174 bits (442), Expect = 6e-44, Method: Composition-based stats. Identities = 60/355 (16%), Positives = 113/355 (31%), Gaps = 52/355 (14%) Query: 139 VLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDI 198 + + + Q ++AP N L L+ + R+ + + N+ + Sbjct: 101 MFIAMDPPKHDVQRKTVQPIVAP----NHLAYLEPIIRERAGKILDDLPIGEEINWVDKV 156 Query: 199 SDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLF 258 S +L +F + D F + V + Sbjct: 157 SIELTTMTL----ATLFD--------------FPWEDRRKLTFWSDVATSAPESGILGTT 198 Query: 259 RTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKA 318 + ++ +F D + W R D +L M + Sbjct: 199 DPEEHEN--LRRQTLFECVDYFM--RLWNERVNAPPKPDLISMLAHGESTKNMDRMEYLG 254 Query: 319 NVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLK 378 N+ ++ GG DTT T+ + + +N LR + L+ Sbjct: 255 NLILLIVGGNDTTRNTISGSVLALHQNPDQDRKLR------------------ENPGLIP 296 Query: 379 ASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPT 438 A + ET+R ++R D L I V + + R+ P ++ Sbjct: 297 AMVSETIRWQTPLAYMRRRAKRDFELGGKTIREGDKVAMWYVSGNRDEEVIDRPNDYWIE 356 Query: 439 RWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF-RVEIQHLSD 492 R ++L FG+GV +C+G R+AEL++ I +L F R+E+ Sbjct: 357 R-------PRVRQHLSFGFGVHRCVGNRLAELQLKIIWEEILARFPRLEVVGPPR 404 >6GK6-A nrPDB Length = 411 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 74/374 (19%), Positives = 131/374 (35%), Gaps = 61/374 (16%) Query: 142 KKSAAWKKDRVALNQEVMA-PEATKNFLPLLDAVSRDFVSVLHRR--IKKAGSGNYSGDI 198 W R E++ P ++F L D V R + + R + + D Sbjct: 40 LDVPIWVAVRYDDCVELLKDPRLIRDFRKLPDEVRRRYFPLSDRTTFMDQHMLDADPPD- 98 Query: 199 SDDLFRFAFESITNVIFGERQ-GMLEEVVNPEAQRFIDAI---YQMF-----------HT 243 +I F R L + A IDA+ +M Sbjct: 99 -----HTRLRAIVQRAFSPRMMEGLRPRIQEIADGLIDAVIDRRRMELIADFAFPLPTAV 153 Query: 244 SVPMLNLPPDLFRLFRTKTW--------KDHVAAWDVIFSKADIYTQNFYWELRQKGSVH 295 +L LP + FR T ++ V + + Y + R+K Sbjct: 154 IAELLGLPVEDRGRFRRWTKILLAPAKDREFVERAQPVVEEFAAY-FRALADARRKAPRD 212 Query: 296 HDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAE 355 G+L + K+S ++ + V +L G +TT + + + + + L + Sbjct: 213 DLISGLLLAEEQEHKLSPAELSSMVFLLLVAGHETTVHLIASGMLLLLSHPAERRRLDED 272 Query: 356 VLAARHQAQGDMATMLQLVPLLKASIKETLRLH-PISVTLQRYLVNDLVLRDYMIPAKTL 414 L+ ++++E LR P ++ R+ + D+ L +PA Sbjct: 273 ------------------PGLVGSAVEEALRCEGPAELSTIRWSLEDIELFGARVPAGEG 314 Query: 415 VQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTI 474 V + A R+P F DP+ FD R + R++GFG G+ CLG +A +E I Sbjct: 315 VAAGLLAANRDPQHFPDPDRFDIGR--------SPNRHIGFGGGIHFCLGAMLARIEAAI 366 Query: 475 FLINMLENF-RVEI 487 +L R+E+ Sbjct: 367 AFSTLLRRLPRIEL 380 >5LIE-A nrPDB Length = 414 Score = 173 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 54/279 (19%), Positives = 97/279 (34%), Gaps = 41/279 (14%) Query: 220 GMLEEVVNPEAQRFIDAIYQM--FHTSVPMLNLPPDLFRLFR---------TKTWKDHVA 268 G+L+ V F+ I +L +P + + + Sbjct: 132 GLLDGVEPGAPFDFVVEIAAELPMQMICILLGVPETDRHWLFEAVEPGFDFRGSRRATMP 191 Query: 269 AWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSK----MSFEDIKANVTEML 324 +V + + +YT ++ D ++ D +S ++ + Sbjct: 192 RLNVEDAGSRLYTYALELIAGKRAEPADDMLSVVANATIDDPDAPALSDAELYLFFHLLF 251 Query: 325 AGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKET 384 + G +TT ++ L +A N LR++ LL +I+E Sbjct: 252 SAGAETTRNSIAGGLLALAENPDQLQTLRSDF------------------ELLPTAIEEI 293 Query: 385 LRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKD 444 +R S + +R + L I A V V + R+P+ F + FD TR + Sbjct: 294 VRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITRKPNP- 352 Query: 445 KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 +LGFG GV CLG +A LE+ + +L F Sbjct: 353 -------HLGFGQGVHYCLGANLARLELRVLFEELLSRF 384 >2Y5N-A nrPDB Length = 417 Score = 173 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 62/405 (15%), Positives = 121/405 (29%), Gaps = 68/405 (16%) Query: 83 QKYGPIYREKL-GNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLL 141 Q+ P+ R + E+ V EDV + + + G LL Sbjct: 47 QETEPVSRVRPPYGEEAWLVTRYEDVRAVLGDGRFVRGPSMTRDEP--RTRPEMVKGGLL 104 Query: 142 KKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDD 201 L + ++ P ++ H + + + D+ Sbjct: 105 SMDPPEHSRLRRLVVKAFTARRAESLRPRAREIA-------HELVDQMAATGQPADLVAM 157 Query: 202 LFR-FAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRT 260 R I ++ VP + Sbjct: 158 FARQLPVRVICELL-----------------------------GVPSADHDRFTRWSGAF 188 Query: 261 KTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANV 320 + + A ++ + R+K ++ +S +++ Sbjct: 189 LSTAEVTAEEMQEAAEQAYAYMGDLIDRRRKEPTDDLVSALVQARDQQDSLSEQELLDLA 248 Query: 321 TEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKAS 380 +L G ++T+ + +Y + +++ L L L+ ++ Sbjct: 249 IGLLVAGYESTTTQIADFVYLLMTRPELRRQL------------------LDRPELIPSA 290 Query: 381 IKETLRLHP--ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPT 438 ++E R P + RY V D+ LR I A V + A R+ F D + D Sbjct: 291 VEELTRWVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVD 350 Query: 439 RWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 R T ++LGFG GV CLG +A +E+ + L +L+ Sbjct: 351 R--------TPNQHLGFGHGVHHCLGAPLARVELQVALEVLLQRL 387 >3MGX-A nrPDB Length = 415 Score = 173 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 47/229 (20%), Positives = 90/229 (39%), Gaps = 27/229 (11%) Query: 285 YWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMAR 344 Y++ ++ L+ D ++ +D+ N +L GG +TT + ++ +A Sbjct: 213 YFDELITARRKEPGDDLVSTLVTDDDLTIDDVLLNCDNVLIGGNETTRHAITGAVHALAT 272 Query: 345 NLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVL 404 + LR ++E LR ++ + R D+ + Sbjct: 273 VPGLLTALRDGSADV------------------DTVVEEVLRWTSPAMHVLRVTTADVTI 314 Query: 405 RDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLG 464 +P+ T V + A R+P F DP+ F P R + R++ FG G+ CLG Sbjct: 315 NGRDLPSGTPVVAWLPAANRDPAEFDDPDTFLPGRKPN--------RHITFGHGMHHCLG 366 Query: 465 RRIAELEMTIFLINMLENF-RVEIQHLSDVGTTFNLILMPEKPISFTFW 512 +A +E+++ L + E RV+++ + E P+ FT Sbjct: 367 SALARIELSVVLRVLAERVSRVDLEREPAWLRAIVVQGYRELPVRFTGR 415 >1ODO-A nrPDB Length = 408 Score = 172 bits (435), Expect = 4e-43, Method: Composition-based stats. Identities = 72/427 (16%), Positives = 137/427 (32%), Gaps = 78/427 (18%) Query: 71 THKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYH 130 T H + ++ GP + V++ V DP + L S + + W A+ Sbjct: 13 TGADHHTEHRTLREGGPATWVDVLGVQAWSVSDPVLLKQLLTSSDVSKDAR--AHWPAFG 70 Query: 131 QYYQR-PIGV-------LLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVL 182 + P+ + +K R + + P ++A+ V L Sbjct: 71 EVVGTWPLALWVAVENMFTAYGPNHRKLRRLVAP-AFSARRVDAMRPAVEAMVTGLVDRL 129 Query: 183 HRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFH 242 D+ +L ++ + G P+ + Sbjct: 130 AEL-----PAGEPVDLRQELAYPLPIAVIGHLMG----------VPQDR----------- 163 Query: 243 TSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGIL 302 D FR + + + + A +Y ++ + D +L Sbjct: 164 ---------RDGFRALVDGVFDTTLDQAEAQANTARLYEVLDQLIAAKRATPGDDMTSLL 214 Query: 303 YRLLGD----SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLA 358 D ++S E+++ + M++ G +TT + ++ + ++R + Sbjct: 215 IAARDDEGDGDRLSPEELRDTLLLMISAGYETTVNVIDQAVHTLLTRPDQLALVRKGEVT 274 Query: 359 ARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQ-RYLVNDLVL-RDYMIPAKTLVQ 416 ++ETLR P L RY V D+ L I + Sbjct: 275 ------------------WADVVEETLRHEPAVKHLPLRYAVTDIALPDGRTIARGEPIL 316 Query: 417 VAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFL 476 + A R P + D + FD TR T +L FG GV CLG +A +E+T+ L Sbjct: 317 ASYAAANRHPDWHEDADTFDATR--------TVKEHLAFGHGVHFCLGAPLARMEVTLAL 368 Query: 477 INMLENF 483 ++ F Sbjct: 369 ESLFGRF 375 >4YT3-A nrPDB Length = 410 Score = 171 bits (434), Expect = 5e-43, Method: Composition-based stats. Identities = 63/356 (17%), Positives = 115/356 (32%), Gaps = 62/356 (17%) Query: 148 KKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAF 207 + R +L P + +N+ P + ++ + + + G DI L Sbjct: 96 HRKRRSLLAAAFTPRSLQNWEPRIQEIADELIGQM--------DGGTEIDIVASLASPLP 147 Query: 208 ESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHV 267 + + G + ++++D LF + Sbjct: 148 IIVMADLMG-----VPSKDRLLFKKWVDT--------------------LFLPFDREKQE 182 Query: 268 AAWDVIFSKADIYTQNFYWELRQK--GSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLA 325 + A Y Q Y + QK +L + + +++ +L Sbjct: 183 EVDKLKQVAAKEYYQYLYPIVVQKRLNPADDIISDLLKSEVDGEMFTDDEVVRTTMLILG 242 Query: 326 GGVDTTSMTLQWHLYEMA-RNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKET 384 GV+TTS L Y + + +V L + + L+ +++E Sbjct: 243 AGVETTSHLLANSFYSLLYDDKEVYQELH------------------ENLDLVPQAVEEM 284 Query: 385 LRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKD 444 LR + L R + D L + V V + A + F DP + R +K Sbjct: 285 LRFRFNLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHRPNNK- 343 Query: 445 KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLI 500 ++L FG G CLG +A LE I L L+ F+ I+ + NL Sbjct: 344 ------KHLTFGNGPHFCLGAPLARLEAKIALTAFLKKFK-HIEAVPSFQLEENLT 392 >3ABB-A nrPDB Length = 408 Score = 171 bits (434), Expect = 5e-43, Method: Composition-based stats. Identities = 38/195 (19%), Positives = 75/195 (38%), Gaps = 27/195 (13%) Query: 289 RQKGSVHHDYRG-ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLK 347 R++ ++ R L + + +++ +L G +TT + + ++ + Sbjct: 205 RKQAEPEDGLLDELIARQLEEGDLDHDEVVMIALVLLVAGHETTVNAIALGALTLIQHPE 264 Query: 348 VQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDY 407 D+L + A ++E LR +S + R D+ + Sbjct: 265 QIDVLLRDPGAVSG------------------VVEELLRFTSVSDHIVRMAKEDIEVGGA 306 Query: 408 MIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRI 467 I A V V+I + R+ + +P+ FD R ++GFG G+ QCLG+ + Sbjct: 307 TIKAGDAVLVSITLMNRDAKAYENPDIFDARR--------NARHHVGFGHGIHQCLGQNL 358 Query: 468 AELEMTIFLINMLEN 482 A E+ I L + Sbjct: 359 ARAELEIALGGLFAR 373 >5XNT-A nrPDB Length = 411 Score = 171 bits (434), Expect = 6e-43, Method: Composition-based stats. Identities = 62/359 (17%), Positives = 116/359 (32%), Gaps = 63/359 (17%) Query: 145 AAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFR 204 +K R L P + +N+ P + ++ + + + + DI L Sbjct: 94 PEHRKRRSLL-AAAFTPRSLQNWEPRIQEIADELIEEMDEETE--------IDIVQSLAS 144 Query: 205 FAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWK 264 + + + G + ++++D LF + Sbjct: 145 PLPIIVMSDLMG-----VPSKDRLLFKKWVDI--------------------LFLPFDKE 179 Query: 265 DHVAAWDVIFSKADIYTQNFYWELRQK--GSVHHDYRGILYRLLGDSKMSFEDIKANVTE 322 ++ A Y Q Y + QK +L + + +++ Sbjct: 180 KQEEVNELKQVAAKEYYQYLYPIVVQKRLNPADDIISDLLKAEVDGEMFTDDEVVRTTML 239 Query: 323 MLAGGVDTTSMTLQWHLYEMA-RNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASI 381 +L GV+TTS L Y + + +V L + + L+ ++ Sbjct: 240 ILGAGVETTSHLLANSFYSLLYDDKEVYQELH------------------ENLDLVPQAV 281 Query: 382 KETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWL 441 +E LR + L R + D L + V V + A + F D + R Sbjct: 282 EEMLRYRFNLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMFEDAFTLNIHRPN 341 Query: 442 SKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLI 500 +K ++L FG G CLG +A LE I L L+ F+ I+ + NL Sbjct: 342 NK-------KHLTFGNGPHFCLGAPLARLEAKIALTTFLKKFK-HIEAVPSFQLEDNLT 392 >3WVS-A nrPDB Length = 401 Score = 171 bits (433), Expect = 6e-43, Method: Composition-based stats. Identities = 46/249 (18%), Positives = 87/249 (34%), Gaps = 37/249 (14%) Query: 244 SVPMLNLPPDLFRLFRTKTWKDHVAAWDVI-------FSKADIYTQNFYWELRQKGSVHH 296 +L +P + F W D + + + + R+ Sbjct: 154 ICELLGVPFEDREKFGR--WTDAILSTSTLNPEEGRVKRMELVGYIGGIIAARRAQPADD 211 Query: 297 DYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV 356 G++ K++ +++ + +L G +TT+ + +Y + + L Sbjct: 212 LISGMIEARDVQDKLTEQELLDHCIGLLIAGHETTASQIPSFVYALLDQPQHWKRL---- 267 Query: 357 LAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVT--LQRYLVNDLVLRDYMIPAKTL 414 L L+ ++++E R P+ RY D+ + ++ A Sbjct: 268 --------------LDDPELIPSAVEELFRFVPLGSGSAAPRYAREDIEVGGTLVRAGEP 313 Query: 415 VQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTI 474 V VA+ A R+ F DPE R ++GFG G+ CLG +A LE+ Sbjct: 314 VLVALGAANRDGLRFEDPEEIKLDR--------PSNHHIGFGHGIHHCLGAPLARLELQE 365 Query: 475 FLINMLENF 483 L +LE Sbjct: 366 ALRALLERL 374 >4WPZ-A nrPDB Length = 397 Score = 171 bits (432), Expect = 8e-43, Method: Composition-based stats. Identities = 67/398 (16%), Positives = 134/398 (33%), Gaps = 51/398 (12%) Query: 96 VESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALN 155 SV + PE +G + P ++ + + + + +A Sbjct: 9 PPSVCELPPELAE---IRDGQSVVEVKFPDGISGWMVTKHADVRKVLVDSRFSSKVMATA 65 Query: 156 QEVMAPEATKNFL-PLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVI 214 M+ T + L + + L + + KA + + + Sbjct: 66 AAAMSETETGKLMNESLVGMDAPEHTRLRKLVTKAFTARRVETLRPRITELV-------- 117 Query: 215 FGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVA-AWDVI 273 G+ LE + P ++ +L +P F W + + W + Sbjct: 118 -GQLLDELETLPRPVDLVKNFSVPLPVRVICELLGVPAGDQDTFHA--WSNALLGDWQQV 174 Query: 274 FSKADIYT-----QNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGV 328 K ++++ ++ GDS ++ +I A +L+ G Sbjct: 175 VEKEAATVSLVNYFGELIAVKRENPADDLISELIAISDGDSTLTEREIIALSIGILSAGH 234 Query: 329 DTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLH 388 +TT+ + L + N + D LR A + ++ E LR Sbjct: 235 ETTANQISMFLVTLLHNPEELDKLRDNREA------------------IPKAVDELLRFV 276 Query: 389 PISVT---LQRYLVNDLVL-RDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKD 444 P++ T + R ++ L ++PA +V A+ R+P F D E + TR + Sbjct: 277 PLTTTGGIIPRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLNVTRENNP- 335 Query: 445 KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLEN 482 +L FG G+ CLG ++A +E+ L +L+ Sbjct: 336 -------HLAFGAGIHHCLGAQLARIELQEALGAILDR 366 >1Q5D-A nrPDB Length = 419 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 80/453 (17%), Positives = 156/453 (34%), Gaps = 75/453 (16%) Query: 70 GTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAY 129 G + ++ ++ PI+ G S + DV+ +F+ E R Y Sbjct: 23 GYAEDPFPAIERLREATPIFYWDEG--RSWVLTRYHDVSAVFRDERFAVSREEWESSAEY 80 Query: 130 HQY-----YQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHR 184 + G+ + R +N P T + LL A + V L Sbjct: 81 SSAIPELSDMKKYGLFGLPPEDHARVRKLVN-----PSFTSRAIDLLRAEIQRTVDQLLD 135 Query: 185 RIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTS 244 + D ++ + A ++ V + + +RF A Sbjct: 136 ARSGQEEFDVVRDYAEGIPMRAISALLKV---------PAECDEKFRRFGSATA------ 180 Query: 245 VPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD-IYTQNFYWELRQKGSVHHDYRGILY 303 L + ++ S + + + + R++ + +D +L Sbjct: 181 ----------RALGVGLVPRVDEETKTLVASVTEGLALLHGVLDERRRNPLENDVLTMLL 230 Query: 304 RLLGD-SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQ 362 + D S++S +++ A V ++A G DTT + + + + R+ + ++++AE Sbjct: 231 QAEADGSRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAE------- 283 Query: 363 AQGDMATMLQLVPLLKASIKETLRLHPIS-VTLQRYLVNDLVLRDYMIPAKTLVQVAIYA 421 L++ ++ E LR I + R+ DL I +V + I + Sbjct: 284 -----------PGLMRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIPS 332 Query: 422 LGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLE 481 R+ T F P+ FD R S L +G G C G +A LE I + + Sbjct: 333 ALRDGTVFSRPDVFDVRRDTSAS--------LAYGRGPHVCPGVSLARLEAEIAVGTIFR 384 Query: 482 NF-RVEIQHLSDVGT--------TFNLILMPEK 505 F ++++ G + N+IL P K Sbjct: 385 RFPEMKLKETPVFGYHPAFRNIESLNVILKPSK 417 >5YSW-A nrPDB Length = 441 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 72/422 (17%), Positives = 131/422 (31%), Gaps = 78/422 (18%) Query: 86 GPIYREKLG-NVESVYVIDPEDVALLFKSEGPNPERFLIPPWVA---------YHQYYQR 135 GP+ R L V E+ + + +RF PW R Sbjct: 64 GPVARATLAAGDPFWLVSGYEEARAVLSDPRFSSDRFQYHPWFKELSPEFRERLRDDKAR 123 Query: 136 PIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYS 195 + + R L + + +D + V + +G + Sbjct: 124 AGSFINMDPPEHTRYRKLLTGQFTVRRIRE-LGARIDEIVAGRVDAML-------AGGTT 175 Query: 196 GDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLF 255 D+ + A + + G R E Q+ A+ QM + V D Sbjct: 176 ADLMTEFAFPAPSLMICELLGVR-----YEDRAEFQQRASALLQM-NAPVAEAVKNADAL 229 Query: 256 RLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFED 315 R F D ++ G+++ D ++ ++ Sbjct: 230 RAFMQALVTD-----------------------KRANPAGDIISGLIHHAGADPALTDDE 266 Query: 316 IKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVP 375 + +L G DTT+ L ++ + + LR + Sbjct: 267 LINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDD------------------PS 308 Query: 376 LLKASIKETLRLHPIS-VTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPEN 434 + +++E LR + + R+ DL IPA + V V++ A R+ + DP+ Sbjct: 309 RIADAVEELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDPD- 367 Query: 435 FDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF---RVEIQHLS 491 D TR +L FG GV QCLG+++A +EM +L R+ + Sbjct: 368 LDLTR--------PRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVPPEE 419 Query: 492 DV 493 Sbjct: 420 VP 421 >6A7I-A nrPDB Length = 411 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 67/415 (16%), Positives = 135/415 (32%), Gaps = 84/415 (20%) Query: 86 GPIYREKL-GNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPI------- 137 GP+ +L G V V + L + I W A+ + + P+ Sbjct: 26 GPLAEVELPGGVHVYAVTRHAEARALLTDSRVVKD---IDVWNAWRR-GEIPMDWPLIGL 81 Query: 138 -----GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSG 192 +L A ++ R L + + + + ++A++ + L Sbjct: 82 ANPGRSMLTVDGADHRRLRT-LVAQALTVKRVERLRAGIEALTNASLEKLAAL-----PA 135 Query: 193 NYSGDISDDLFR-FAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLP 251 D+ + I+ ++ ++ +P + + + F T P +P Sbjct: 136 GEPVDLKAEFAYPLPMNVISELM------GVDAADHPRLK---ELFEKFFSTQTPPEEVP 186 Query: 252 PDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKM 311 D+ I + ++ ++ + Sbjct: 187 ---------------QMMADLGALFTKIV------DAKRTNPGDDLTSALIAASENGDHL 225 Query: 312 SFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDM-LRAEVLAARHQAQGDMATM 370 + E+I + ++A G +TT + + + + + + L E+ Sbjct: 226 TDEEIVNTLQLIIAAGHETTISLIVNVVEALQTHPEQRKKVLNGEIG------------- 272 Query: 371 LQLVPLLKASIKETLRL-HPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFF 429 I+ETLR P S L R+ D+ + D ++P + ++ ALGR+ + Sbjct: 273 ------WDGVIEETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGALGRDEEQY 326 Query: 430 -FDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 FD TR T R++ FG G C G ++ LE I L + E F Sbjct: 327 GPTAGEFDATR--------TPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERF 373 >4DO1-A nrPDB Length = 410 Score = 169 bits (427), Expect = 4e-42, Method: Composition-based stats. Identities = 65/380 (17%), Positives = 127/380 (33%), Gaps = 64/380 (16%) Query: 135 RPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNY 194 RP ++L+ A+ +V++P + + + + G + Sbjct: 93 RPPSLILEADPPAHTRPRAVLSKVLSPAT----MKTIRDGFAAAADAKVDELLQRGCIDA 148 Query: 195 SGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDL 254 D+++ F + R+ +L + V PP+ Sbjct: 149 IADLAEAYPLSVFPDAMGLKQEGREHLLP-----------------YAGLVFNAFGPPNE 191 Query: 255 FRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDS-KMSF 313 R + H Q + E Q+ ++ G D+ +++ Sbjct: 192 LRQTAIERSAPH---------------QAYVNEQCQRPNLAPGGFGACIHAFTDTGEITP 236 Query: 314 EDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQL 373 ++ V +L+ G+DTT + +Y +AR LR++ Sbjct: 237 DEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSD------------------ 278 Query: 374 VPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPE 433 L + + +E +R T R ++ L +I V + + + R+P + DP+ Sbjct: 279 PTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPD 338 Query: 434 NFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDV 493 +D TR S ++GFG GV C+G+ +A LE + L + I V Sbjct: 339 LYDITRKTSG--------HVGFGSGVHMCVGQLVARLEGEVMLSALARKV-AAIDIDGPV 389 Query: 494 GTTFNLILMPEKPISFTFWP 513 FN L + + P Sbjct: 390 KRRFNNTLRGLESLPVKLTP 409 >4OQS-A nrPDB Length = 433 Score = 168 bits (425), Expect = 6e-42, Method: Composition-based stats. Identities = 52/352 (14%), Positives = 107/352 (30%), Gaps = 77/352 (21%) Query: 136 PIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYS 195 P + + + R L + K P + ++ D + + Sbjct: 91 PGWFINMDAPEHTRYRRMLISQ-FTVRRIKELEPRIVQITEDHLDAM-------AKAGPP 142 Query: 196 GDISDDLFRFAFE-SITNVIFGERQGMLEEVVNPEAQRFIDAI-YQMFHTSVPMLNLPPD 253 D+ I ++ + E + ++ + + L Sbjct: 143 VDLVQAFALPVPSLVICELL---GVSYADHAFFQEQTTIMASVDKTQDEVTTALGKLTRY 199 Query: 254 LFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSF 313 + L TK +L L+ D+ ++ Sbjct: 200 IAELVATKRLSPKD--------------------------------DLLGSLITDTDLTD 227 Query: 314 EDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQL 373 E++ +L G +TT+ L + + ++ + L + Sbjct: 228 EELTNIALLLLVAGHETTANMLGLGTFALLQHPEQIAALDS------------------- 268 Query: 374 VPLLKASIKETLRLHPISV--TLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFD 431 +++E LR I T R + D+ L MI V + + A+ R+P F + Sbjct: 269 ----PDAVEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDE 324 Query: 432 PENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 P+ R + ++ FG G+ QCLG+++A +EM I + F Sbjct: 325 PDILQLDR-------VDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARF 369 >4TX3-A nrPDB Length = 404 Score = 167 bits (423), Expect = 1e-41, Method: Composition-based stats. Identities = 41/244 (16%), Positives = 86/244 (35%), Gaps = 31/244 (12%) Query: 244 SVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYW---ELRQKGSVHHDYRG 300 ++ +P D +F + A+ A Y R++ + G Sbjct: 158 LCELIGVPRDDQAMFLQLCHRHLDASLSARKRAAAGEAFARYLVAMMARERKDPGDGFIG 217 Query: 301 ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR 360 + GD+ ++ E+++ +++ G D S + + + R+ + LR + +A Sbjct: 218 SIVAEHGDT-ITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQSA- 275 Query: 361 HQAQGDMATMLQLVPLLKASIKETLRLHPISVT-LQRYLVNDLVLRDYMIPAKTLVQVAI 419 ++ E +R + R V D+++ D +I V ++ Sbjct: 276 -----------------DRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSL 318 Query: 420 YALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINM 479 R+ D + D TR T ++ FG G+ CLG + L++ I + Sbjct: 319 PMANRDRALLPDADRLDVTR--------TPVPHVAFGHGIHHCLGAALTRLQLRIAYTAL 370 Query: 480 LENF 483 F Sbjct: 371 WRRF 374 >5FOI-A nrPDB Length = 408 Score = 166 bits (421), Expect = 2e-41, Method: Composition-based stats. Identities = 59/347 (17%), Positives = 114/347 (32%), Gaps = 71/347 (20%) Query: 139 VLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDI 198 +L+ + R + + P ++ + + L DI Sbjct: 99 MLMLDPPEHTRLRRMF-ISAFSVRQVETMRPEIEKIVDGILDRLLAL-------EPPVDI 150 Query: 199 SDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLF 258 L A T VI +L +P + F Sbjct: 151 ---LTHLALPMSTQVI------------------------------CHLLGVPYEDREFF 177 Query: 259 RTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGI---LYRLLGDSKMSFED 315 + ++ D A I + L + + H D + + L +++ ++ Sbjct: 178 QERSELASRPNDD-RSMPALIELVEYLDGLVRTKTAHPDTGLLGTAVTERLLKGEITHQE 236 Query: 316 IKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVP 375 + N +LA G +T++ + + + R+ + LR + Sbjct: 237 LVNNAVLLLAAGHETSANQVTLSVLTLLRHPETAAELR------------------EQPE 278 Query: 376 LLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENF 435 L+ ++ E LR H I+ L+R D+VL D+ I A + + + + + F F Sbjct: 279 LMPNAVDELLRYHSIADGLRRAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATF 338 Query: 436 DPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLEN 482 D R ++ FG+G QCLG+ +A LEM + L + Sbjct: 339 DIHR--------PARHHVAFGYGPHQCLGQNLARLEMEVTLGKLFRR 377 >4MM0-A nrPDB Length = 399 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 65/385 (16%), Positives = 127/385 (32%), Gaps = 68/385 (17%) Query: 101 VIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMA 160 V EDV + S+ R +P + V+ + R L+++ A Sbjct: 50 VTRYEDVRFVL-SDPRFSVRQDLPGAPRLTEMTFES--VMTTDPPVHTRLRRLLSRDFTA 106 Query: 161 PEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFR-FAFESITNVIFGERQ 219 + P L+ ++ + + ++ DI + L F I ++ Sbjct: 107 RR-IERMRPRLEEIAEGLLDEMEKK-------GAPADIVESLAVPFPITVICELL----- 153 Query: 220 GMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADI 279 V + RF M + + +D AA D + S D Sbjct: 154 ----GVPMVDVARFRGWADTMVSLTGYSM---------------EDWTAARDALESYLDG 194 Query: 280 YTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHL 339 +++ ++ D++++ D+++ +L G + S L + Sbjct: 195 LVA-----AKRENPGSDLLSALVATAAEDNELTDHDVRSLSLILLLAGYEPASNQLGSSV 249 Query: 340 YEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVT-LQRYL 398 + R LR + LL ++++E +R P L R Sbjct: 250 LTLLRFPDRLAELRRD------------------PGLLPSAVEELMRYAPAGDGALFRVT 291 Query: 399 VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWG 458 + D+ + D IPA + V + A +P F DP R ++ G G Sbjct: 292 LEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTGLRLDR--------PDNQHTALGHG 343 Query: 459 VRQCLGRRIAELEMTIFLINMLENF 483 + CLG +A +E+ + + +L F Sbjct: 344 IHFCLGAALARVELQVAIGALLRRF 368 >5FYF-A nrPDB Length = 470 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 85/497 (17%), Positives = 165/497 (33%), Gaps = 85/497 (17%) Query: 8 PRSVLVKGCQTFLSAPREGLGRLR-VPTGEGAGISTRSPRPFNEIPSPGDNGWLNLYHFW 66 P ++G + +SA R+ G R +P I + +I N +L W Sbjct: 24 PMQRQIQGLKFLMSAKRKTFGPRRPMPEFVETPIPDVNTLALEDI--DVSNPFLYRQGQW 81 Query: 67 RETGTHKVHLHHVQNFQK---YGPIYREKLGNVESVYVIDPEDV--ALLFKSEGPNPERF 121 R ++ ++QK +GP + + ++V D+ A G PE Sbjct: 82 RAY-FKRLRDEAPVHYQKNSPFGPFWSVTRFE-DILFVDKSHDLFSAEPQIILGDPPEGL 139 Query: 122 LIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSV 181 + + + + + Q V+AP+ L ++ + R Sbjct: 140 SVE--------------MFIAMDPPKHDVQRSSVQGVVAPKN----LKEMEGLIRSRTGD 181 Query: 182 LHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLE------EVVNPEAQRFID 235 + + N+ +S +L ++ + + ER ++E + F D Sbjct: 182 VLDSLPTDKPFNWVPAVSKELTGRMLATLLDFPYEERHKLVEWSDRMAGAASATGGEFAD 241 Query: 236 AIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVH 295 ++ RL W+D A L Q Sbjct: 242 ENAMFDD----AADMARSFSRL-----WRDKEARRAAGEEPGFDLI-----SLLQSNKET 287 Query: 296 HDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAE 355 D + M + N+T ++ GG DTT ++ L M + + L+A Sbjct: 288 KDLI--------NRPM---EFIGNLTLLIVGGNDTTRNSMSGGLVAMNEFPREFEKLKA- 335 Query: 356 VLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLV 415 L+ + E +R ++R D+ L I V Sbjct: 336 -----------------KPELIPNMVSEIIRWQTPLAYMRRIAKQDVELGGQTIKKGDRV 378 Query: 416 QVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIF 475 + + R+ F +P+ F R +++ ++ FG+GV +C+G R+AEL++ I Sbjct: 379 VMWYASGNRDERKFDNPDQFIIDRKDARN-------HMSFGYGVHRCMGNRLAELQLRIL 431 Query: 476 LINMLENFR-VEIQHLS 491 +L+ F +E+ Sbjct: 432 WEEILKRFDNIEVVEEP 448 >3A50-A nrPDB Length = 411 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 58/342 (16%), Positives = 123/342 (35%), Gaps = 45/342 (13%) Query: 144 SAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLF 203 S W+ R+ +Q P + L+D H R++K +++ ++L Sbjct: 64 SKDWR-HRLPEDQRADMPATPTPMMILMD-------PPDHTRLRKLVGRSFTVRRMNELE 115 Query: 204 RFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTW 263 E ++ G +++ A + + +L LP + F + Sbjct: 116 PRITEIADGLLAGLPTDGPVDLMREYAFQIPVQV------ICELLGLPAEDRDDFSAWSS 169 Query: 264 KDHVAAWDVIFSKADIYTQNFYWEL--RQKGSVHHDYRGILYRL--LGDSKMSFEDIKAN 319 + + A + +L R++ L + + ++S E++ A Sbjct: 170 VLVDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDMDGDRLSQEELVAM 229 Query: 320 VTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKA 379 +L G +TT + + + + + +L + L+ + Sbjct: 230 AMLLLIAGHETTVNLIGNGVLALLTHPDQRKLLAED------------------PSLISS 271 Query: 380 SIKETLRL-HPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPT 438 +++E LR P+S R+ D+ IPA +V + + A R+ + +P+ D T Sbjct: 272 AVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDIT 331 Query: 439 RWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML 480 R S + FG G+ CLG ++A LE + + + Sbjct: 332 RDASGG--------VFFGHGIHFCLGAQLARLEGRVAIGRLF 365 >2Z36-A nrPDB Length = 413 Score = 166 bits (419), Expect = 3e-41, Method: Composition-based stats. Identities = 59/433 (13%), Positives = 133/433 (30%), Gaps = 75/433 (17%) Query: 80 QNFQKYGPIYREKL-GNVESVYVIDPEDVALLFKSEGPNPERF------LIPPWVAYHQY 132 + ++ PI + +L ++ +V E+ + + ++ Q Sbjct: 29 ERLRERAPINKVRLTSGGQAWWVSGHEEARAVLADGRFSSDKRKDGFPLFTLDAATLQQL 88 Query: 133 YQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSG 192 +P +L A R + E + P + + F+ + + Sbjct: 89 RSQPPLMLGMDGAEHSAARRPVIGE-FTVKRLAALRPRIQDIVDHFIDDML------ATD 141 Query: 193 NYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPP 252 D+ L + + G + F + M + Sbjct: 142 QRPVDLVQALSLPVPSLVICELLGVPYTDHD---------FFQSRTTMMVS--------- 183 Query: 253 DLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMS 312 RT A ++ D+ T ++ + + R + + Sbjct: 184 ------RTSMEDRRRAFAELRAYIDDLIT------RKESEPGDDLFSRQIARQRQEGTLD 231 Query: 313 FEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQ 372 + + +L G +TT+ + + + + + +++A Sbjct: 232 HAGLVSLAFLLLTAGHETTANMISLGVVGLLSHPEQLTVVKA------------------ 273 Query: 373 LVPLLKASIKETLRLHPISVTLQ-RYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFD 431 +++E LR I+ + R D+ + I A V V++ + +P F D Sbjct: 274 NPGRTPMAVEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKD 333 Query: 432 PENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLEN---FRVEIQ 488 P D R +L FG+G QCLG+ +A +E+ I + R+ + Sbjct: 334 PAVLDVER--------GARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRIPSLRLAV- 384 Query: 489 HLSDVGTTFNLIL 501 + DV + ++ Sbjct: 385 PMEDVPFKGDSVI 397 >5Y1I-A nrPDB Length = 403 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 47/247 (19%), Positives = 89/247 (36%), Gaps = 34/247 (13%) Query: 244 SVPMLNLPPDLFRLFR----TKTWKDHVAAWDVIFSKADIYTQNFYWEL--RQKGSVHHD 297 ML +P + + ++D KA I + EL + G D Sbjct: 152 ICEMLGVPYEDREFLQQNNNAMIYRD---TAQGDAQKAAIAQAMYLKELVGTKLGDRGDD 208 Query: 298 YRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVL 357 L + +++ +D +L G +TT+ + + N + +R Sbjct: 209 ILSDLAVQVEAGEITQDDAAGIGMMLLGAGHETTANMIALGTLALLENPEQLAEVR---- 264 Query: 358 AARHQAQGDMATMLQLVPLLKASIKETLRLHPISV-TLQRYLVNDLVLRDYMIPAKTLVQ 416 ++ +++E LR I+ T++R D+ + +I A + Sbjct: 265 ------------DSDDPKVIVNTVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIV 312 Query: 417 VAIYALGREPTFFFD-PENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIF 475 + A +P + + P+ D R R+L FG+GV QCLG +A +E+ I Sbjct: 313 FPLNAANWDPDLYPEAPDRLDIHR-------ANARRHLAFGYGVHQCLGATLARVELQIV 365 Query: 476 LINMLEN 482 +L Sbjct: 366 YSTLLRR 372 >1EHE-A nrPDB Length = 403 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 63/425 (14%), Positives = 133/425 (31%), Gaps = 81/425 (19%) Query: 95 NVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVAL 154 + + +V E ++ + +G + + + ++ Sbjct: 48 HKDVCFVATSEKLSKVRTRQGFPELSASGKQAA-------KAKPTFVDMDPPEHMHQRSM 100 Query: 155 NQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVI 214 + PEA KN P + D + + K+ G N D+ + I + Sbjct: 101 VEPTFTPEAVKNLQPYIQRTVDDLLEQM----KQKGCANGPVDLVKEFALPVPSYIIYTL 156 Query: 215 FGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIF 274 G F D Y ++ R + T ++ AA + Sbjct: 157 LGV--------------PFNDLEYLTQQNAI----------RTNGSSTAREASAANQELL 192 Query: 275 SKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMT 334 I + E + + + D +L G T Sbjct: 193 DYLAILVEQRLVE-----PKDDIISKLCTEQVKPGNIDKSDAVQIAFLLLVAGNATMVNM 247 Query: 335 LQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPIS-VT 393 + + +A++ L+A L ++E R H S + Sbjct: 248 IALGVATLAQHPDQLAQLKA------------------NPSLAPQFVEELCRYHTASALA 289 Query: 394 LQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTR-WLSKDKNITYFRN 452 ++R D+++ D ++ A + + + R+ F +P+ F+ R W +D Sbjct: 290 IKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNRKWPPQDP------- 342 Query: 453 LGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFW 512 LGFG+G +C+ +A+ E+T + + F D+ + +P I+ + Sbjct: 343 LGFGFGDHRCIAEHLAKAELTTVFSTLYQKF-------PDLK-----VAVPLGKIN--YT 388 Query: 513 PFNQE 517 P N++ Sbjct: 389 PLNRD 393 >2WIO-A nrPDB Length = 431 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 57/339 (16%), Positives = 104/339 (30%), Gaps = 57/339 (16%) Query: 145 AAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFR 204 + R ++ P + P + V+R + S D+ D L Sbjct: 113 PEHRALRKVVS-SAFTPRTISDLEPRIRDVTRSLL----------ADAGESFDLVDVLAF 161 Query: 205 FAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWK 264 +I + G + + ++F D S ++++ D Sbjct: 162 PLPVTIVAELLG--------LPPMDHEQFGD-------WSGALVDIQMDD-----PTDPA 201 Query: 265 DHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEML 324 DV+ R+ ++ + + E+ T +L Sbjct: 202 LAERIADVLNPLTAYLKAR--CAERRADPGDDLISRLVLAEVDGRALDDEEAANFSTALL 259 Query: 325 AGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKET 384 G TT++ L + + + D + + A ++E Sbjct: 260 LAGHITTTVLLGNIVRTLDEHPAHWDAAAEDPGR------------------IPAIVEEV 301 Query: 385 LRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKD 444 LR P +QR + IPA +V + + R+ DP+ FDP+R Sbjct: 302 LRYRPPFPQMQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSR----- 356 Query: 445 KNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 L FG GV CLG +A LE + L ++ F Sbjct: 357 -KSGGAAQLSFGHGVHFCLGAPLARLENRVALEEIIARF 394 >3A1L-A nrPDB Length = 425 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 51/247 (20%), Positives = 90/247 (36%), Gaps = 37/247 (14%) Query: 246 PMLNLPPDLFRLFRT-----KTWKDHVAAWDVIFSKADIYTQNFYWELRQK------GSV 294 +L +P + R + A +++A+ +Q F R++ Sbjct: 163 ALLGIPEEDHTWLRANAVALQEASTTRARDGRGYARAEAASQEFTRYFRREVDRRGGDDR 222 Query: 295 HHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRA 354 ++ S +S + I +L G +TT+ L + + + V D LR Sbjct: 223 DDLLTLLVRARDTGSPLSVDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELR- 281 Query: 355 EVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTL 414 A+++E +R P + R+ D+ L D+ IP + Sbjct: 282 -----------------TTPESTPAAVEELMRYDPPVQAVTRWAYEDIRLGDHDIPRGSR 324 Query: 415 VQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTI 474 V + + R+P F DP+ D R R +GFG G+ CLG +A E I Sbjct: 325 VVALLGSANRDPARFPDPDVLDVHR--------AAERQVGFGLGIHYCLGATLARAEAEI 376 Query: 475 FLINMLE 481 L +L+ Sbjct: 377 GLRALLD 383 >4OQR-A nrPDB Length = 457 Score = 165 bits (417), Expect = 5e-41, Method: Composition-based stats. Identities = 51/346 (14%), Positives = 105/346 (30%), Gaps = 77/346 (22%) Query: 142 KKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDD 201 + + R L + K P + ++ D + + D+ Sbjct: 136 MDAPEHTRYRRMLISQ-FTVRRIKELEPRIVRITEDHLDAM-------AKAGPPVDLVQA 187 Query: 202 LFRFAFE-SITNVIFGERQGMLEEVVNPEAQRFIDAI-YQMFHTSVPMLNLPPDLFRLFR 259 I ++ + E + ++ + + L + L Sbjct: 188 FALPVPSLVICELL---GVSYADHAFFQEQTTIMVSVDKTQDEVTTALGKLTRYIAELVA 244 Query: 260 TKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKAN 319 TK +L L+ D+ ++ E++ Sbjct: 245 TKRLSPKD--------------------------------DLLGSLITDTDLTDEELTNI 272 Query: 320 VTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKA 379 +L G +TT+ L + + ++ + L + Sbjct: 273 ALILLVAGHETTANMLGLGTFALLQHPEQIANLDS-----------------------PD 309 Query: 380 SIKETLRLHPISV--TLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDP 437 +++E LR I T R + D+ L MI V + + A+ R+P F +P+ Sbjct: 310 AVEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQL 369 Query: 438 TRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 R + ++ FG G+ QCLG+++A +EM I + F Sbjct: 370 DR-------VDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARF 408 >1LG9-A nrPDB Length = 398 Score = 164 bits (416), Expect = 6e-41, Method: Composition-based stats. Identities = 49/271 (18%), Positives = 89/271 (32%), Gaps = 31/271 (11%) Query: 217 ERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSK 276 +R +E +P A ++ +P D +F A+ Sbjct: 125 DRLDEMERAGSPADLIAFVADKVPGAVLCELVGVPRDDRDMFMKLCHGHLDASLSQKRRA 184 Query: 277 ADIYTQNFYWEL---RQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSM 333 A + Y R++ G + GD + E+++ +++ G D S Sbjct: 185 ALGDKFSRYLLAMIARERKEPGEGMIGAVVAEYGDDA-TDEELRGFCVQVMLAGDDNISG 243 Query: 334 TLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVT 393 + + M R+ + D R + +A+ ++ E +R + + Sbjct: 244 MIGLGVLAMLRHPEQIDAFRGDEQSAQR------------------AVDELIRYLTVPYS 285 Query: 394 -LQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRN 452 R DL L I V ++ A R+P D + D TR + Sbjct: 286 PTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTR--------EPIPH 337 Query: 453 LGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 + FG GV CLG +A LE+ + F Sbjct: 338 VAFGHGVHHCLGAALARLELRTVFTELWRRF 368 >3TYW-A nrPDB Length = 417 Score = 164 bits (415), Expect = 7e-41, Method: Composition-based stats. Identities = 45/246 (18%), Positives = 87/246 (35%), Gaps = 31/246 (12%) Query: 242 HTSVPMLNLPPDLFRLFRTKTW----KDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHD 297 +L +P FR T ++ A R++ Sbjct: 161 SVICELLGIPRHDLEFFRDVTRISGSRNSTAEQVSEALGGLFGLLGGLVAERREEPRDDL 220 Query: 298 YRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVL 357 ++ L ++ E + + + + G +TT+ + + ++ LR + Sbjct: 221 ISKLVTDHLVPGNVTTEQLLSTLGITINAGRETTTSMIALSTLLLLDRPELPAELRKD-- 278 Query: 358 AARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQ-RYLVNDLVLRDYMIPAKTLVQ 416 L+ A++ E LR+ ++ ++ R D+ L +PA V Sbjct: 279 ----------------PDLMPAAVDELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVI 322 Query: 417 VAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFL 476 + +P F DPE D R T ++ FG+GV QC+G+ +A LE+ + L Sbjct: 323 ALLAGANHDPEQFDDPERVDFHR--------TDNHHVAFGYGVHQCVGQHLARLELEVAL 374 Query: 477 INMLEN 482 +L Sbjct: 375 ETLLRR 380 >3P3Z-A nrPDB Length = 416 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 44/221 (19%), Positives = 78/221 (35%), Gaps = 26/221 (11%) Query: 265 DHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEML 324 D V ++ ++K D + R D + +++ V +L Sbjct: 192 DQDILVKVEQGLGRMFDYLVAAIEKRKVEPGDDLTSDIVRAFHDGVLDDYELRTLVATVL 251 Query: 325 AGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKET 384 G +TT+ L +Y+ A++ ++ + L +++E Sbjct: 252 VAGYETTNHQLALAMYDFAQHPDQWMKIK------------------ENPELAPQAVEEV 293 Query: 385 LRLHP-ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSK 443 LR P + VT R D + IP T V + + R+P F D + FD T Sbjct: 294 LRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADADRFDIT----- 348 Query: 444 DKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFR 484 ++ FG G CLG +A LE+T + + Sbjct: 349 --VKREAPSIAFGGGPHFCLGTALARLELTEAVAALATRLD 387 >6FSH-A nrPDB Length = 398 Score = 163 bits (413), Expect = 2e-40, Method: Composition-based stats. Identities = 41/244 (16%), Positives = 86/244 (35%), Gaps = 31/244 (12%) Query: 244 SVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWEL---RQKGSVHHDYRG 300 ++ +P D +F A+ A + Y R++ + G Sbjct: 152 LCELIGVPRDDRDMFMKLCHGHLDASLSQKRRAALGDKFSRYLLAMIARERKDPGDGFIG 211 Query: 301 ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR 360 + GD+ ++ E+++ +++ G D S + + + R+ + LR + +A Sbjct: 212 SIVAEHGDT-ITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQSA- 269 Query: 361 HQAQGDMATMLQLVPLLKASIKETLRLHPISVT-LQRYLVNDLVLRDYMIPAKTLVQVAI 419 ++ E +R + R V D+++ D +I V ++ Sbjct: 270 -----------------DRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSL 312 Query: 420 YALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINM 479 R+ D + D TR T ++ FG G+ CLG + L++ I + Sbjct: 313 PMANRDRALLPDADRLDVTR--------TPVPHVAFGHGIHHCLGAALTRLQLRIAYTAL 364 Query: 480 LENF 483 F Sbjct: 365 WRRF 368 >5NWS-A nrPDB Length = 435 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 63/422 (14%), Positives = 133/422 (31%), Gaps = 79/422 (18%) Query: 81 NFQKYGPIYREK-LGNVESVYVIDPEDVALLFK------SEGPNPERFLIPPWVAYHQYY 133 ++ GP+ R + + +V +DV + + + P P P Sbjct: 42 RLRERGPVVRGRFVDGTPVWFVTRYDDVRAVLRDPRFVNTPSPVPGEGGADPREGMMDLL 101 Query: 134 QRP-------IGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRI 186 P +G +L L A P ++ ++ L + Sbjct: 102 NVPEPLRVYLLGSILDSDPPDHPRLRRLVTRAFAARRILGLRPGIERIA----DRLLAEL 157 Query: 187 KKAGSGNYSGDISDDLFR-FAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSV 245 + + + D+ + + I L + + +R+ + Sbjct: 158 PRREEEDGTVDLLEHFAYPLSITVIC---------ELVGIPATDLERWRE-------WGG 201 Query: 246 PMLNLPPD-LFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYR 304 ++++ P+ L F H +++ ++ D L R Sbjct: 202 DLVSMRPERLRHSFPVMIDYCHRL------------------IEQRRAALTDDLLSELIR 243 Query: 305 LLGDS--KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQ 362 D ++S + + ++ G +T++ + + + +LR + Sbjct: 244 AQDDDGGRLSDIETVTMILTLVLAGHETSAHLIGNGTAALLTHPGQWALLRKD------- 296 Query: 363 AQGDMATMLQLVPLLKASIKETLRL-HPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYA 421 LL ++ E +R + V RY DL L + VQ+ + + Sbjct: 297 -----------PALLPRAVHELMRWCGSVHVARLRYATEDLELAGTPVARGDAVQLVLVS 345 Query: 422 LGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLE 481 +P + DP+ D TR ++GFG G+ CLG +A E + L +LE Sbjct: 346 ANFDPRHYSDPDRLDITRHQEGQAE----NHVGFGHGIHYCLGATLARQEGEVALARLLE 401 Query: 482 NF 483 + Sbjct: 402 TY 403 >3NC3-A nrPDB Length = 441 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 67/394 (17%), Positives = 122/394 (30%), Gaps = 59/394 (14%) Query: 95 NVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVAL 154 +++S ++ DV + + +P+ F V + R + R + Sbjct: 73 SIDSYFISRYHDVRYILQ----HPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIV 128 Query: 155 NQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRF--AFESITN 212 + + L L + + L + G D+ +D + ++ Sbjct: 129 VRS-----FIGDALDHLSPLIKQNAENLLAPYLERGKS----DLVNDFGKTFAVCVTMDM 179 Query: 213 VIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDV 272 + +R + FI +I Q L L + Sbjct: 180 LGLDKRDHEKISEWHSGVADFITSISQSPEARAHSLWCSEQLSQYLMPVI---------- 229 Query: 273 IFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTS 332 + R+ + +S +DI A + +L + Sbjct: 230 --------------KERRVNPGSDLISILCTSEYEGMALSDKDILALILNVLLAATEPAD 275 Query: 333 MTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISV 392 TL +Y + N + + +L L+ +I ETLR P Sbjct: 276 KTLALMIYHLLNNPEQMN------------------DVLADRSLVPRAIAETLRYKPPVQ 317 Query: 393 TLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRW--LSKDKNITYF 450 + R L D V+ I T+V I A R+P F P+ F+ R K Sbjct: 318 LIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIKSAFSGAA 377 Query: 451 RNLGFGWGVRQCLGRRIAELEMTIFLINMLENFR 484 R+L FG G+ C+G A+ E+ I +L+ R Sbjct: 378 RHLAFGSGIHNCVGTAFAKNEIEIVANIVLDKMR 411 >5IT1-A nrPDB Length = 399 Score = 162 bits (409), Expect = 5e-40, Method: Composition-based stats. Identities = 52/360 (14%), Positives = 104/360 (28%), Gaps = 64/360 (17%) Query: 139 VLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDI 198 +L + + DR L +E + A+ + ++ + + D+ Sbjct: 87 LLWQDAPEHTDDRKLLAKEFTVRR--------MQALRPNIQRIVDEHLDAIEARGGPVDL 138 Query: 199 SDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLF 258 + + +FG + E Q +A+ ++ Sbjct: 139 VKTFANPVPSMVISDLFG-----VPAERRAEFQEIAEAMMRV------------------ 175 Query: 259 RTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKA 318 D AA + R+ ++ D + + Sbjct: 176 ------DQDAAATEAAGMRLGGLLYQLVQERRANPGDDLISALITTEDPDGVIDDMFLMN 229 Query: 319 NVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLK 378 +L DTT+ + + +L+ + L+ Sbjct: 230 AAGTLLIAAHDTTACMIGLGTALLLDRPDQLALLQKD------------------PSLIG 271 Query: 379 ASIKETLRLHPISV-TLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDP 437 +++E LR I +R D + I V + + +P F DPE FD Sbjct: 272 NAVEELLRYLTIGQFGAERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDI 331 Query: 438 TRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTF 497 TR + +L FG+G QC+G+++A +E+ I + F F Sbjct: 332 TRRPAP--------HLAFGFGAHQCIGQQLARIELQIVFGTLFRRFPTLRLAKPVEELRF 383 >6HQD-A nrPDB Length = 420 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 65/426 (15%), Positives = 132/426 (30%), Gaps = 66/426 (15%) Query: 84 KYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKK 143 +YGP + + + V + + +F S+ N L + L Sbjct: 54 EYGPYWSITKFS-DIVAI---DTNHKVFSSDHTNGSFVLDDTTLNAVDGGIYLPNFLGMD 109 Query: 144 SAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLF 203 R+ ++ ++AP+ F + R+ + + N+ +S +L Sbjct: 110 PPKHDVHRMVVSP-IVAPQNLLRFEATI----RERTKRVLSELPIGEEFNWVDRVSIELT 164 Query: 204 RFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTW 263 ++ + F +R+ + + + ++ RL+ Sbjct: 165 TMMLATLLDFPFDDRRKLTRWSDIITTRPGYGLVDSWEQRESELMECLAYFQRLY----- 219 Query: 264 KDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEM 323 RQ D +L ++ D + + Sbjct: 220 -----------------------AERQAMPPKPDLISMLAHSPEMQDLTPTDFLGTLALL 256 Query: 324 LAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKE 383 + GG DTT ++ + D +R LL + I E Sbjct: 257 IVGGNDTTRSSMSGSAMACHLYPQEFDKVR------------------NNRALLASVIPE 298 Query: 384 TLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSK 443 +R ++R + D+ R I V + + R+ P +F R ++ Sbjct: 299 VVRWQTPIAHMRRTALEDVEFRGKQIRKGDKVVMWYLSGNRDDEVIDRPMDFIADRPRAR 358 Query: 444 DKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF-RVEIQHLS---DVGTTFNL 499 +L FG+G+ +CLG R+AEL++ I M E + R+E+ Sbjct: 359 -------HHLSFGFGIHRCLGNRLAELQLKILWEEMCERYSRIEVCGEPVRVPSNLVHGY 411 Query: 500 ILMPEK 505 I +P + Sbjct: 412 IDIPVR 417 >1UE8-A nrPDB Length = 367 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 58/245 (23%), Positives = 97/245 (39%), Gaps = 36/245 (14%) Query: 246 PMLNLPPDLFRLFRTKTWKDHVA----AWDVIFSKADIYTQNFYWELRQKGSVHHDYRGI 301 ML + PD+ ++ K W D VA D IFS Y + + ++ S Sbjct: 129 KMLGINPDVKKV---KDWSDLVALRLGRADEIFSIGRKYLELISFSKKELDSRKGKEIVD 185 Query: 302 LYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARH 361 L + +S +S + + ++ G +TT+ + + + D +R + Sbjct: 186 LTGKIANSNLSELEKEGYFILLMIAGNETTTNLIGNAIEDFTLY-NSWDYVREKGALK-- 242 Query: 362 QAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYA 421 +++E LR P + R + +RD +I LV+V I + Sbjct: 243 ------------------AVEEALRFSPPVMRTIRVTKEKVKIRDQVIDEGELVRVWIAS 284 Query: 422 LGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLE 481 R+ F DP++F P R T +L FG G+ CLG +A LE I L + Sbjct: 285 ANRDEEVFKDPDSFIPDR--------TPNPHLSFGSGIHLCLGAPLARLEARIALEEFAK 336 Query: 482 NFRVE 486 FRV+ Sbjct: 337 KFRVK 341 >5LIV-A nrPDB Length = 450 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 63/363 (17%), Positives = 117/363 (32%), Gaps = 59/363 (16%) Query: 138 GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGD 197 G+ + + R N P A + FV + ++ +G D Sbjct: 122 GLAAMQGDEHARMRRVYNM-FFLPRAVSQYE-------ERFVRPISEQVVDRLAGKPRVD 173 Query: 198 ISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRL 257 + +D + +FG ++ T + + L R+ Sbjct: 174 LLEDFAMELPRRVIGELFGFPA------------------EKLHETDERVRAMLRGLVRM 215 Query: 258 FRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKM-SFEDI 316 D A + + + R+ G + R L M + E Sbjct: 216 ------HDPAAVAESQRAYGETLGLITEVVERESRDTSDTLLGEILRTLKAEHMDTIEAS 269 Query: 317 KANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPL 376 + V ++ GG +TTS + ++ + + +R + L Sbjct: 270 RQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQD------------------PSL 311 Query: 377 LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFD 436 L A+I+E +R P S + R + D+ L D + A T+V +A A + T + PE +D Sbjct: 312 LPAAIEEGMRWCPSSFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYD 371 Query: 437 PTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFR-VEIQHLSDVGT 495 R N+ FG G C+G +A +E + L +L F + Sbjct: 372 IDRKPLPAANV-------FGGGAHFCVGAPLARMEARVGLQALLARFPGLRAVPEERPSF 424 Query: 496 TFN 498 + Sbjct: 425 MYG 427 >4XE3-A nrPDB Length = 407 Score = 160 bits (404), Expect = 2e-39, Method: Composition-based stats. Identities = 41/247 (16%), Positives = 84/247 (34%), Gaps = 33/247 (13%) Query: 244 SVPMLNLPPDLFRLFRTKT----WKDHVAAWDVIFSKAD-IYTQNFYWELRQKGSVHHDY 298 +L +P + LFRT + + A ++ + D + + R+ Sbjct: 157 ICELLGVPLEDRDLFRTFSDAMLSSTRLTAAEIQRVQQDFMVYMDGLVAQRRDAPTEDLL 216 Query: 299 RGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLA 358 + D ++ +I +L G +T+ + ++ + K + L A+ Sbjct: 217 GALALATDNDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLTERKRYESLVAD--- 273 Query: 359 ARHQAQGDMATMLQLVPLLKASIKETLRLHPISVT--LQRYLVNDLVLRDYMIPAKTLVQ 416 L+ A+++E LR P+ R D+ L + A Sbjct: 274 ---------------PALVPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCV 318 Query: 417 VAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFL 476 V + R+ F + D R + ++ FG G C+G ++ LE+ L Sbjct: 319 VHFASANRDEEVFDHADELDFHRERNP--------HIAFGHGAHHCIGAQLGRLELQEAL 370 Query: 477 INMLENF 483 ++ F Sbjct: 371 SALVRRF 377 >6F88-A nrPDB Length = 400 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 62/363 (17%), Positives = 117/363 (32%), Gaps = 59/363 (16%) Query: 138 GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGD 197 G+ + + R N P A + FV + ++ +G D Sbjct: 72 GLAAMQGDEHARMRRVYNM-FFLPRAVSQYE-------ERFVRPISEQVVDRLAGKPRVD 123 Query: 198 ISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRL 257 + +D + +FG ++ T + + L R+ Sbjct: 124 LLEDFAMELPRRVIGELFGFPA------------------EKLHETDERVRAMLRGLVRM 165 Query: 258 FRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKM-SFEDI 316 D A + + + R+ G + R L M + E Sbjct: 166 ------HDPAAVAESQRAYGETLGLITEVVERESRDTSDTLLGEILRTLKAEHMDTIEAS 219 Query: 317 KANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPL 376 + V ++ GG +TTS + ++ + + +R + L Sbjct: 220 RQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQD------------------PSL 261 Query: 377 LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFD 436 L A+I+E +R P + + R + D+ L D + A T+V +A A + T + PE +D Sbjct: 262 LPAAIEEGMRWCPSNFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYD 321 Query: 437 PTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFR-VEIQHLSDVGT 495 R N+ FG G C+G +A +E + L +L F + Sbjct: 322 IDRKPLPAANV-------FGGGAHFCVGAPLARMEARVGLQALLARFPGLRAVPEERPSF 374 Query: 496 TFN 498 + Sbjct: 375 MYG 377 >5H1Z-A nrPDB Length = 407 Score = 159 bits (401), Expect = 4e-39, Method: Composition-based stats. Identities = 48/274 (17%), Positives = 96/274 (35%), Gaps = 39/274 (14%) Query: 231 QRFIDAIYQMFHT-SVPMLNLPPDLFRLFRTKTWKDHVAAWDVIF-------SKADIYTQ 282 ++D + T + +L P R T W D +++ +Y Sbjct: 139 FDWVDTVSVELTTQMLAILFDFPWEERRKLT-FWSDWAGDIELVKNEELRLERLRHMYEC 197 Query: 283 NFY----WELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWH 338 Y W + D ++ ++M + N+ ++ GG DTT T+ Sbjct: 198 GGYFQNLWNAKIGKPPTPDLISMMIHSDAMAEMDQMEFLGNLILLIVGGNDTTRNTMSAV 257 Query: 339 LYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYL 398 Y + + L A+ ++ +++E +R ++R Sbjct: 258 AYGLDLFPDQRAKLEAD------------------PSMIPNTVQEIIRWQTPLAHMRRTA 299 Query: 399 VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWG 458 D L I A + + + R+ + F + + R ++ R+L FG G Sbjct: 300 TVDSELEGQQIKAGDKLALWYISANRDESVFENADRIIVDRPNAR-------RHLAFGHG 352 Query: 459 VRQCLGRRIAELEMTIFLINML-ENFRVEIQHLS 491 + +C+G R+AEL++ + L M RV + Sbjct: 353 IHRCVGARLAELQIAVLLEEMAKRRMRVNVLGEP 386 >3ABA-A nrPDB Length = 403 Score = 158 bits (399), Expect = 5e-39, Method: Composition-based stats. Identities = 59/407 (14%), Positives = 124/407 (30%), Gaps = 73/407 (17%) Query: 101 VIDPEDVALLFKSEGPNPERFLIPPWVAYHQ--YYQRPI--GVLLKKSAAWKKDRVALNQ 156 V E+V L + + + +P + Q+P +L + DR L + Sbjct: 48 VTGYEEVRALLRDSSFSVQ---VPHALHTQDGVVTQKPGRGSLLWQDEPEHTSDRKLLAK 104 Query: 157 EVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFG 216 E + A+ + ++ + + D+ + + +FG Sbjct: 105 EFTVRR--------MQALRPNIQRIVDEHLDAIEARGGPVDLVKTFANAVPSMVISDLFG 156 Query: 217 ERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSK 276 V F D M RL +++ Sbjct: 157 --------VPVERRAEFQDIAEAMMRVDQDAAATEAAGMRLG------------GLLYQL 196 Query: 277 ADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQ 336 + R+ ++ D + + +L DTT+ + Sbjct: 197 V---------QERRANPGDDLISALITTEDPDGVVDDMFLMNAAGTLLIAAHDTTACMIG 247 Query: 337 WHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISV-TLQ 395 + + +LR + L+ +++E LR I + Sbjct: 248 LGTALLLDSPDQLALLRED------------------PSLVGNAVEELLRYLTIGQFGGE 289 Query: 396 RYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGF 455 R D+ L I V + A +P F +PE FD TR + +L F Sbjct: 290 RVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITRRPAP--------HLAF 341 Query: 456 GWGVRQCLGRRIAELEMTIFLINMLENFR-VEI-QHLSDVGTTFNLI 500 G+G QC+G+++A +E+ I + + + + + ++ +++ Sbjct: 342 GFGAHQCIGQQLARIELQIVFETLFRRLPGLRLAKPVEELRFRHDMV 388 >3TKT-A nrPDB Length = 450 Score = 158 bits (399), Expect = 6e-39, Method: Composition-based stats. Identities = 47/208 (22%), Positives = 73/208 (35%), Gaps = 27/208 (12%) Query: 285 YWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMAR 344 R++ I ++ MS D + G DTTS + +AR Sbjct: 248 LAAERRRNPTDDVATVIANAVVDGEPMSDRDTAGYYIITASAGHDTTSASSAGAALALAR 307 Query: 345 NLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVL 404 + + ++A+ LL ++E +R R D L Sbjct: 308 DPDLFARVKADRN------------------LLPGIVEEAIRWTTPVQHFMRTAATDTEL 349 Query: 405 RDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLG 464 I A + + A +P F +P FDPTR R+L FG G QCLG Sbjct: 350 CGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTR--------PANRHLAFGAGSHQCLG 401 Query: 465 RRIAELEMTIFLINMLENFR-VEIQHLS 491 +A LEM + L +L+ +E+ Sbjct: 402 LHLARLEMRVLLDVLLDRVDSLELAGEP 429 >5HDI-A nrPDB Length = 404 Score = 158 bits (398), Expect = 7e-39, Method: Composition-based stats. Identities = 76/434 (17%), Positives = 137/434 (31%), Gaps = 71/434 (16%) Query: 78 HVQNFQKYGPIYREKLGNVESVY--------VIDPEDVALLFKSEGPNPERFLIPPWVAY 129 + + G ++R + +V + PED + + P+ Sbjct: 22 LYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTYTAEGTAKPFEM- 80 Query: 130 HQYYQRPIGVL-LKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKK 188 P VL A R + + + + + V+ + + Sbjct: 81 -DPLGGPTHVLATADDPAHAVHRKLVLRHL----------------AAKRIRVMEQFTVQ 123 Query: 189 AGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPML 248 A + + D + ++ N + L + +P+ I Q+ Sbjct: 124 AADRLWVDGMQDGCIEW-MGAMANRLPMMVVAELIGLPDPD-------IAQLVKWGYAAT 175 Query: 249 NLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGD 308 L L D + A V + Y F R + G L Sbjct: 176 QLLEGL-------VENDQLVAAGVALMELSGYI--FEQFDRAAADPRDNLLGELATACAS 226 Query: 309 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMA 368 ++ + + + A G ++T+ L ++ +A +Q +RA Sbjct: 227 GELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQVRA-------------- 272 Query: 369 TMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTF 428 LL A I+ETLR P R++ N L +PA + + + A R+P Sbjct: 273 ----NPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQ 328 Query: 429 FFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQ 488 F P F R K ++ FG G C+G +A LE I L +L+ + Sbjct: 329 FEAPGEFRLDRAGGKG-------HISFGKGAHFCVGAALARLEARIVLRLLLDR--TSVI 379 Query: 489 HLSDVGTTFNLILM 502 +DVG IL+ Sbjct: 380 EAADVGGWLPSILV 393 >3SN5-A nrPDB Length = 491 Score = 157 bits (397), Expect = 1e-38, Method: Composition-based stats. Identities = 87/494 (17%), Positives = 162/494 (32%), Gaps = 59/494 (11%) Query: 53 SPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFK 112 P +NG + + G + + N +K+G ++ KL ++ +P + Sbjct: 15 PPLENGLIPYLGCALQFGANPLEF-LRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVL- 72 Query: 113 SEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLD 172 G + ++ + R I + + +N + L + Sbjct: 73 CHGKYFDWKKFHFALSAKAFGHRSIDPMDGNTTE------NINDTFIKTLQGHALNSLTE 126 Query: 173 AVSRDFVSVLHRRIKKAGSGNYSGD--ISDDLFRFAFESITNVIFGERQGMLEEVVNPEA 230 ++ + ++ + + +R FE+ IFG R + Sbjct: 127 SMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFG-RDLTRRDTQKAHI 185 Query: 231 QRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQ 290 +D Q P + L H A + + L++ Sbjct: 186 LNNLDNFKQFDK------VFPALVAGLPIHMFRTAHNAR-------EKLAESLRHENLQK 232 Query: 291 KGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLA--GGVDTTSMTLQWHLYEMARNLKV 348 + S+ L L D+ +F+D++ T ++ T W L++M RN + Sbjct: 233 RESISELIS--LRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEA 290 Query: 349 QDMLRAEVLAARHQAQGDMA----------TMLQLVPLLKASIKETLRLHPISVTLQRYL 398 EV A ++ L +P+L + IKE+LRL S+ + R Sbjct: 291 MKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI-RTA 349 Query: 399 VNDLVL----RDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNIT------ 448 D L Y I ++ + + +P + DP F R+L ++ Sbjct: 350 KEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCN 409 Query: 449 ----YFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEI-----QHLSDVGTTFNL 499 + + FG G C GR A E+ FLI ML F +E+ + + L Sbjct: 410 GLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGL 469 Query: 500 -ILMPEKPISFTFW 512 IL P I F + Sbjct: 470 GILPPLNDIEFKYK 483 >2WM5-A nrPDB Length = 435 Score = 157 bits (397), Expect = 1e-38, Method: Composition-based stats. Identities = 56/375 (14%), Positives = 124/375 (33%), Gaps = 59/375 (15%) Query: 139 VLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDI 198 +++ ++ R +++ T + ++A RD L + + + Sbjct: 117 MIVLDDPRHQRLR-----SIVSRAFTPKVVARIEAAVRDRAHRLVSSMIANNPDRQADLV 171 Query: 199 SDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLF 258 S+ + I +++ + + QR + P L D Sbjct: 172 SELAGPLPLQIICDMM---------GIPKADHQRIFHWTNVILGFGDPDLATDFD----- 217 Query: 259 RTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRL-LGDSKMSFEDIK 317 + + ADI ++ + H D L + ++S +I Sbjct: 218 ------------EFMQVSADIGAYATALAEDRRVNHHDDLTSSLVEAEVDGERLSSREIA 265 Query: 318 ANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLL 377 + ++ G +TT + + ++R + +D ++ L Sbjct: 266 SFFILLVVAGNETTRNAITHGVLALSRYPEQRDRWWSDFDG-----------------LA 308 Query: 378 KASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDP 437 +++E +R V ++R L D+ LR + A V + + R+ + F DP FD Sbjct: 309 PTAVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDL 368 Query: 438 TRWLSKDKNITYFRNLGF-GWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTT 496 R + +LGF G G CLG +A E+ + + ++ + Sbjct: 369 ARNPNP--------HLGFGGGGAHFCLGANLARREIRVAFDELRRQMP-DVVATEEPARL 419 Query: 497 FNLILMPEKPISFTF 511 + + K + T+ Sbjct: 420 LSQFIHGIKTLPVTW 434 >2RFC-A nrPDB Length = 343 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 53/248 (21%), Positives = 98/248 (39%), Gaps = 37/248 (14%) Query: 246 PMLNLPPDLFRLFRTKTWKDHVA--AWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILY 303 +L +P LF K W D++ D F+ + + E+ K H + Sbjct: 109 KILGIPDSDMPLF--KLWSDYIIGNKRDENFNYVNNRMVSRLLEI-FKSDSHGIINVLAG 165 Query: 304 RLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQA 363 L + K++ ++ + ++ GG +TT+ + + + N + D Sbjct: 166 SSLKNRKLTMDEKIKYIMLLIIGGNETTTNLIGNMIRVIDENPDIID------------- 212 Query: 364 QGDMATMLQLVPLLKASIKETLRLHPISVTLQ-RYLVNDLVLRDYMIPAKTLVQVAIYAL 422 + ++ETLR + L R+ D + + I V V + + Sbjct: 213 --------DALKNRSGFVEETLRYYSPIQFLPHRFAAEDSYINNKKIKKGDQVIVYLGSA 264 Query: 423 GREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLEN 482 R+ TFF +P+ F R +L FG G+ CLG +A LE +I L ++L + Sbjct: 265 NRDETFFDEPDLFKIGR---------REMHLAFGIGIHMCLGAPLARLEASIALNDILNH 315 Query: 483 F-RVEIQH 489 F R++I + Sbjct: 316 FKRIKIDY 323 >6F0B-A nrPDB Length = 395 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 57/301 (18%), Positives = 115/301 (38%), Gaps = 35/301 (11%) Query: 219 QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKAD 278 L E P+ A+ T +L +P + R T+ K V+A A+ Sbjct: 122 LDGLAETAPPQDMLEAFAVPVASATVFRLLGIPAED-RALLTRCVKGVVSAVGSEDEGAE 180 Query: 279 IY-TQNFYWELRQKGSVHHDYRGILYRLLGDS----KMSFEDIKANVTEMLAGGVDTTSM 333 ++ T Y + ++ RL+ +++F + + ++ GG DTT+ Sbjct: 181 VFRTLGEYIGGLVQDPSELPEDSLIRRLVTGPYQEKQLTFHETIGVILMLIVGGYDTTAS 240 Query: 334 TLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISV- 392 T+ L A + ++ + +PLL ++E LR H +S Sbjct: 241 TISLSLVSYALQPEKFSVVHEHP---------------ERIPLL---VEELLRYHTVSQL 282 Query: 393 TLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRN 452 L R D+ + + A +V A+ R+ + F +P+ D R + Sbjct: 283 GLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR--------PSVPH 334 Query: 453 LGFGWGVRQCLGRRIAELEMTIFLINMLENFR-VEI-QHLSDVGTTFNLILMPEKPISFT 510 +GFG+G QC+G+ +A +E+ + ++ + + L D+ ++ + T Sbjct: 335 VGFGYGPHQCVGQALARVELQEAIPAVIRRLPGMRLACALEDLPFRHDMATYGIHELPMT 394 Query: 511 F 511 + Sbjct: 395 W 395 >6M7L-A nrPDB Length = 404 Score = 156 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 63/402 (15%), Positives = 123/402 (30%), Gaps = 80/402 (19%) Query: 86 GPIYREKL--GNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKK 143 GP+ R L G+ + + + V + SE ++ +I HQ P +L Sbjct: 48 GPLVRIPLEDGSAVHWFALGYDVVREVLGSEK--FDKRVIGTHFN-HQEMALPGNLLQLD 104 Query: 144 SAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLF 203 + R + + + P + A+ D + + A +G + + Sbjct: 105 PPEHTRLRRMVAP-AYSVRRMQALEPRVQAIVDDHLDTM------ASTGPPVEFLREVAG 157 Query: 204 RFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTW 263 A L +P D T Sbjct: 158 PMAARVAC----------------------------------EFLGIPLDDRGELIRLTA 183 Query: 264 KDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEM 323 V+ A + ++ G++ R G +S E++ + Sbjct: 184 HRGGKRRRVLNGHAYLAYMRELAARLRR-DPGDGMLGMVARDHGAD-ISDEELAGLCAVV 241 Query: 324 LAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKE 383 + V+ T L + + + +LR + L + +++E Sbjct: 242 MNSSVEQTESCLAAGTLLLLEHPEQFALLR------------------ERPELGEQAVEE 283 Query: 384 TLRLHPISVTL-QRYLVNDLVLRDYMIPAKTLVQVAIYALGR-EPTFFFDPENFDPTRWL 441 +R + L R D+ + +I V ++ A R +P + FD TR Sbjct: 284 IVRYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAANRADPAL----DGFDITRKE 339 Query: 442 SKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 S R++ FG G+ CLG +A +E+ I ++ F Sbjct: 340 S--------RHVAFGHGIHHCLGAPLARMELRIAFTTLVSRF 373 >1F4U-A nrPDB Length = 368 Score = 155 bits (392), Expect = 4e-38, Method: Composition-based stats. Identities = 68/361 (18%), Positives = 120/361 (33%), Gaps = 57/361 (15%) Query: 143 KSAAWKKDRVALNQEVMAP---------EATKNFLPLLDAVSRDFVSVLHRRIKKAGSGN 193 W+ +EV+ + L + R + + + Sbjct: 17 DGNIWQVFSYRYTKEVLNNFSKFSSDLTGYHERLEDLRNGKIRFDIPTRYTML------T 70 Query: 194 YSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLP-- 251 + D+L + + + ++ LE + + +D+I V L +P Sbjct: 71 SDPPLHDELRSMSADIFSP----QKLQTLETFIRETTRSLLDSIDPREDDIVKKLAVPLP 126 Query: 252 --PDLFRLFRTKTWKDHVAAW-DVIF----SKADIYT-QNFYWELRQKGSVHHDYRGILY 303 L K+ W D++ +I+ Y EL H + + Sbjct: 127 IIVISKILGLPIEDKEKFKEWSDLVAFRLGKPGEIFELGKKYLELIGYVKDHLNSGTEVV 186 Query: 304 RLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQA 363 + +S +S + + +L G +TT+ + + + R + +R E L Sbjct: 187 SRVVNSNLSDIEKLGYIILLLIAGNETTTNLISNSVIDFTRF-NLWQRIREENL------ 239 Query: 364 QGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALG 423 LKA I+E LR P + R + L D I V+V I + Sbjct: 240 ------------YLKA-IEEALRYSPPVMRTVRKTKERVKLGDQTIEEGEYVRVWIASAN 286 Query: 424 REPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 R+ F D E F P R + +L FG G+ CLG +A LE I + + F Sbjct: 287 RDEEVFHDGEKFIPDRNPNP--------HLSFGSGIHLCLGAPLARLEARIAIEEFSKRF 338 Query: 484 R 484 R Sbjct: 339 R 339 >5Z9I-A nrPDB Length = 398 Score = 155 bits (392), Expect = 4e-38, Method: Composition-based stats. Identities = 43/233 (18%), Positives = 85/233 (36%), Gaps = 33/233 (14%) Query: 282 QNFYWELR----QKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQW 337 YW R +K +++ + K++ I +L G TT+M + Sbjct: 189 MRDYWHERAAESRKRPREDLISQLVHAEVDGQKLNDSQISNIANRLLVNGHLTTAMLIAN 248 Query: 338 HLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRY 397 + + +RA+ L+ A ++E++R + R Sbjct: 249 TMLCLDAFSDQDARVRADR------------------SLVPALLEESMRYMSPICGVGRA 290 Query: 398 LVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGW 457 +++ + +IP L+ V A R+ F P+ FD R + +LGFG Sbjct: 291 TNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGR--------SPNAHLGFGR 342 Query: 458 GVRQCLGRRIAELEMTIFLINMLEN---FRVEIQHLSDVGTTFNLILMPEKPI 507 G+ CLGR++A +E + +L+ R + + + + P+ Sbjct: 343 GIHFCLGRQLARMESKAAVEILLDRLPTLRADPANPPTFLQVVDASGVATLPV 395 >3OFT-A nrPDB Length = 396 Score = 154 bits (390), Expect = 6e-38, Method: Composition-based stats. Identities = 72/370 (19%), Positives = 125/370 (33%), Gaps = 77/370 (20%) Query: 140 LLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDIS 199 L + A K R + + +A P + AV+R + L + GS ++ D + Sbjct: 87 LQQDGAEHKAFRTPV-MKGLASRFVVALEPKVQAVARKLMESL----RPRGSCDFVSDFA 141 Query: 200 DDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFR 259 + L F ++ +V +R P L +L Sbjct: 142 EILPLNIFLTLIDVPLEDR---------------------------------PRLRQLGV 168 Query: 260 TKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKAN 319 T D + + AD Y F E R + IL +G + ++ + Sbjct: 169 QLTRPDGSMTVEQLKQAADDYLWPFI-EKRMAQPGDDLFSRILSEPVGGRPWTVDEARRM 227 Query: 320 VTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKA 379 +L GG+DT + + +AR+ + Q +LR + L+ A Sbjct: 228 CRNLLFGGLDTVAAMIGMVALHLARHPEDQRLLR------------------ERPDLIPA 269 Query: 380 SIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTR 439 + E +R +P + R V D+ I LV + +P F PE R Sbjct: 270 AADELMRRYPTV-AVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDR 328 Query: 440 WLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNL 499 L+ R+ G G +C+G +A +E+ +FL L G Sbjct: 329 GLAP------IRHTTMGVGAHRCVGAGLARMEVIVFLREWL-------------GGMPEF 369 Query: 500 ILMPEKPISF 509 L P+K ++ Sbjct: 370 ALAPDKAVTM 379 >6DCD-A nrPDB Length = 424 Score = 154 bits (389), Expect = 9e-38, Method: Composition-based stats. Identities = 63/318 (19%), Positives = 106/318 (33%), Gaps = 48/318 (15%) Query: 219 QGMLEEVVNPEAQRFIDAIYQMFHTSV--PMLNLPPDLFRLFRTKTWKDHVAAWDVIFSK 276 L+E + FI + F T V +L +P D + FR D + + + Sbjct: 134 DRQLDEFLGAGECEFISEYAKPFATLVIADLLGVPEDDRKDFRVVLGADRMGRVGALDHE 193 Query: 277 A---------DIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFE--DIKANVTEMLA 325 + D + + R++ +D L + E D+ + T + A Sbjct: 194 SVGVNPLQWLDDKFSAYIEDRRRQPR--NDVLTALATATYPDGSTPEVIDVVRSATFLFA 251 Query: 326 GGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETL 385 G +TT+ L + + +Q LR + L+ I+E+L Sbjct: 252 AGQETTAKLLTAAMRVLGDRPDIQRRLR------------------ENRSLIPNFIEESL 293 Query: 386 RLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDK 445 R+ + R + I A T+V V A R+P F DP F R Sbjct: 294 RMDSPVKSDSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDR------ 347 Query: 446 NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLEN-FRVEIQ---HLSDVGTTF---- 497 ++ F GV C G +A +E + L +L+ + I H + Sbjct: 348 -PNVREHMAFARGVHSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADDRRYTYEP 406 Query: 498 NLILMPEKPISFTFWPFN 515 IL + TF P Sbjct: 407 TYILRGLTELHITFTPAG 424 >5DQN-A nrPDB Length = 426 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 43/250 (17%), Positives = 82/250 (32%), Gaps = 36/250 (14%) Query: 241 FHTSVPMLNLPPD----LFRLFRTKTWKDHVAAWDV---IFSKADIYTQNFYWELRQKGS 293 +L +P D LFR T + DV + S I E R Sbjct: 159 LQAIAELLGVPQDDRDKLFRWSNEMTAGEDPEYADVDPAMSSFELISYAMKMAEERAVNP 218 Query: 294 VHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLR 353 ++ + K+S ++ V + G +TT ++ + A+N ++ + Sbjct: 219 TEDIVTKLIEADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFAQNPDQWELYK 278 Query: 354 AEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKT 413 E + + E +R QR + D+ L I Sbjct: 279 KERP--------------------ETAADEIVRWATPVSAFQRTALEDVELGGVQIKKGQ 318 Query: 414 LVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGW-GVRQCLGRRIAELEM 472 V ++ + + F DP F+ R + ++GFG G C+G +A + + Sbjct: 319 RVVMSYRSANFDEEVFEDPHTFNILRSPNP--------HVGFGGTGAHYCIGANLARMTI 370 Query: 473 TIFLINMLEN 482 + + +N Sbjct: 371 NLIFNAIADN 380 >1GWI-A nrPDB Length = 411 Score = 152 bits (383), Expect = 5e-37, Method: Composition-based stats. Identities = 37/199 (18%), Positives = 76/199 (38%), Gaps = 27/199 (13%) Query: 287 ELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNL 346 ++ ++ ++ +I + + M+A G +TT + + ++ + Sbjct: 203 AAKRAAPGDDLTSALIQASENGDHLTDAEIVSTLQLMVAAGHETTISLIVNAVVNLSTHP 262 Query: 347 KVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPI-SVTLQRYLVNDLVLR 405 + + ++ + A ++ETLR S L R+ D+ + Sbjct: 263 EQRALVLSGEAE------------------WSAVVEETLRFSTPTSHVLIRFAAEDVPVG 304 Query: 406 DYMIPAKTLVQVAIYALGREPTFF-FDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLG 464 D +IPA + V+ ALGR+ + FD TR + R++ FG G C G Sbjct: 305 DRVIPAGDALIVSYGALGRDERAHGPTADRFDLTR-------TSGNRHISFGHGPHVCPG 357 Query: 465 RRIAELEMTIFLINMLENF 483 ++ +E + L + F Sbjct: 358 AALSRMEAGVALPALYARF 376 >4PWV-A nrPDB Length = 446 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 51/341 (14%), Positives = 121/341 (35%), Gaps = 61/341 (17%) Query: 139 VLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDI 198 + + A + R L + +P+A K P++D + + ++ ++ G +++ D+ Sbjct: 118 LAVTDGAMHRGLRNVLLKS-FSPQALK---PIVDQIRVNTTRLVVDAARR-GECDFAADV 172 Query: 199 SDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLF 258 ++ + + V +R+ +L+ + + D Sbjct: 173 AEQIPLNTISDLLGVPAADREFLLKLNKSALSSEDAD----------------------- 209 Query: 259 RTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKA 318 + AW + + + R+ + ++ ++ E I Sbjct: 210 -----QSATDAW--LARNEILLYFSELVAERRAKPTEDVISVLANSMVDGKPLTEEVIVL 262 Query: 319 NVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLK 378 N ++ GG +T+ +++ + + ++LR + L+ Sbjct: 263 NCYSLILGGDETSRLSMIDSVQTFTQYPDQWELLRDGKVT------------------LE 304 Query: 379 ASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPT 438 ++ +E LR ++ R V D+ L +I A +V + + R+ F DP FD Sbjct: 305 SATEEVLRWATPAMHFGRRAVTDMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDLN 364 Query: 439 RWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINM 479 R + +++ FG+G CLG + E+ L + Sbjct: 365 R--------SPNKHITFGYGPHFCLGAYLGRAEVHALLDAL 397 >5DE9-A nrPDB Length = 410 Score = 148 bits (373), Expect = 5e-36, Method: Composition-based stats. Identities = 71/469 (15%), Positives = 136/469 (28%), Gaps = 91/469 (19%) Query: 49 NEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKL--GNVESVYVIDPED 106 +P D ++L + + GP+ R L G + V +D Sbjct: 8 QAVPPVRDWPAVDL--------PGSDFDPVLTELMREGPVTRISLPNGEGWAWLVTRHDD 59 Query: 107 VALLFKSEGPNPERFLIPPWVAYHQYYQRPIG-VLLKKSAAWKKDRVALNQEVMAPEATK 165 V L+ E + +++ G V + R ++ A Sbjct: 60 VRLVTNDPRFGREAVMDRQVTRLAPHFRPARGAVGFLDPPDHTRLRRSVAAAFTARG--- 116 Query: 166 NFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDD-LFRFAFESITNVIFGERQGMLEE 224 ++ V +L + D+++ L F I Sbjct: 117 -----VERVRERSRGMLDELVDAMLRAGPPADLTEAVLSPFPIAVIC------------- 158 Query: 225 VVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFR----LFRTKTWKDHVAAWDVIFSKADIY 280 ++ +P + H A Sbjct: 159 ---------------------ELMGVPATDRHSMHTWTQLILSSSHGAEVSERAKNEMNA 197 Query: 281 TQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLY 340 + LR S D +L +G +++ + + GG + + + Sbjct: 198 YFSDLIGLR-SDSAGEDVTSLLGAAVGRDEITLSEAVGLAVLLQIGG-EAVTNNSGQMFH 255 Query: 341 EMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHP--ISVTLQRYL 398 + ++ + LR+E + +I E LR P +V L R Sbjct: 256 LLLSRPELAERLRSE------------------PEIRPRAIDELLRWIPHRNAVGLSRIA 297 Query: 399 VNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWG 458 + D+ ++ I A V V+ A R+P F DP+ D R + ++ FG+G Sbjct: 298 LEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFERSPNP--------HVSFGFG 349 Query: 459 VRQCLGRRIAELEMTIFLINMLEN---FRVEIQHLSDVGTTFNLILMPE 504 C G +A LE + + +L+ ++ + LI PE Sbjct: 350 PHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDVPFKKGALIRGPE 398 >6CVC-A nrPDB Length = 433 Score = 148 bits (373), Expect = 6e-36, Method: Composition-based stats. Identities = 64/463 (13%), Positives = 134/463 (28%), Gaps = 65/463 (14%) Query: 53 SPGDNGW----LNLYHFW-RETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDV 107 P + L FW R+ ++ +L + + Sbjct: 19 PPPEVPLADIELGSLEFWGRDDDFRDGAFATLRREAPISFWPPIELAGLTAGKGHWALTK 78 Query: 108 ALLFKSEGPNPERFLIPPWVAYHQYYQRP---IGVLL-KKSAAWKKDRVALNQEVMAPEA 163 +PE F P + H G ++ ++ R +++ Sbjct: 79 HDDIHFASRHPEIFHSSPNIVIHDQTPELAEYFGSMIVLDDPRHQRLR-----SIVSRAF 133 Query: 164 TKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLE 223 T + ++A R+ L + + + +S+ + I + Sbjct: 134 TPKVVARIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIIC-----------D 182 Query: 224 EVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQN 283 + PE Q+FH + +L D V + T Sbjct: 183 MMGIPEEDH-----EQIFHWTNVILGF-------GDPDLTTDFDEFLQVSMAIGGYATA- 229 Query: 284 FYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMA 343 + R+ ++ + ++S +I ++ G +TT + + ++ Sbjct: 230 -LADDRRVNHHGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNAISHGMLALS 288 Query: 344 RNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLV 403 R + ++ L +++E +R V ++R L D+ Sbjct: 289 RYPDERAKWWSDFDG-----------------LAATAVEEIVRWASPVVYMRRTLSQDVD 331 Query: 404 LRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGF-GWGVRQC 462 LR + A V + + R+ F DP FD TR + +GF G G C Sbjct: 332 LRGTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQ--------VGFGGGGAHFC 383 Query: 463 LGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEK 505 LG +A E+ + + + I ++ Sbjct: 384 LGANLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKR 426 >5L1U-A nrPDB Length = 401 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 74/408 (18%), Positives = 128/408 (31%), Gaps = 71/408 (17%) Query: 83 QKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLK 142 QK GPI R ++ V ++V L P + R V L Sbjct: 28 QKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQP---SAKSAARAFMVALA 84 Query: 143 KSAAWKKD--RVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISD 200 + + R A + ++ P + L L+ V L + + + D+ Sbjct: 85 AGDDHETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDEL---LDQLAASAPPVDLHR 141 Query: 201 DL-FRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFR 259 L FR + +++ VP+ + Sbjct: 142 VLSFRLPTMVVCDLL-----------------------------GVPLADRERFGQWARG 172 Query: 260 TKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKAN 319 T D+ + + D + R++ D L D +S DI Sbjct: 173 TFDQSDNEHSANTFQQVVDYMLE---LVARKRVEPGDDILSELI-AEKDGALSDADIAHL 228 Query: 320 VTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKA 379 +L G +TT + + + RN + L + L A Sbjct: 229 GNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAED------------------PGLAPA 270 Query: 380 SIKETLRL----HPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENF 435 +++E LRL + + RY D+ + + +I V +AI A + F D F Sbjct: 271 AVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGGLF 330 Query: 436 DPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 D TR + +L FG G R C+GR +A +E+T + Sbjct: 331 DLTR-------VRPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRL 371 >4Z5Q-A nrPDB Length = 423 Score = 146 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 62/441 (14%), Positives = 134/441 (30%), Gaps = 84/441 (19%) Query: 49 NEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKL-GNVESVYVIDPEDV 107 E P+P + K+ F+ PI R +L + V +D Sbjct: 30 TEKPAPVAYPFTGSEGLELSQSYAKL-------FEDGDPI-RVQLPFGEPAWLVTRYDDA 81 Query: 108 ALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNF 167 + + P +L + R L + P ++ Sbjct: 82 RFVLTDRRFSRHLATQRDEPRMTP-RAVPESILTMDPPDHTRLRT-LVSKAFTPRRIESK 139 Query: 168 LPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVN 227 + ++ V+ + +G ++ + +A VI Sbjct: 140 RAWIGELAAGLVADMK-------AGGAPAEL---VGSYALAIPVTVI------------- 176 Query: 228 PEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFR--TKTWKDHVAAWDVIFSKADIYTQNFY 285 +L +P D R D ++ + Q ++ Sbjct: 177 -----------------CELLGVPEDDRTRLRGWCDAALSTGELTDEECVQSFMDLQKYF 219 Query: 286 WEL---RQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEM 342 +L R+ ++ +++ ++ +L GG +TT+ + ++ + Sbjct: 220 EDLVKERRAEPRDDLTSALIEARDAHDRLAEPELIGLCISILIGGFETTASEISSFVHVL 279 Query: 343 ARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTL--QRYLVN 400 + ++ L A+ A + A+++E LR P + RY + Sbjct: 280 QQRRELWTRLCADPEA------------------IPAAVEELLRFVPFAANGISPRYALE 321 Query: 401 DLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVR 460 D+ + ++ V V A+ R+ F + + R R++ FG G Sbjct: 322 DMTVGGVLVREGEPVIVDTSAVNRDGLVFDNADEVVIDR--------ADNRHMVFGHGAH 373 Query: 461 QCLGRRIAELEMTIFLINMLE 481 CLG +A +E+ L ++E Sbjct: 374 HCLGAHLARVELQEALKALVE 394 >5HIW-A nrPDB Length = 398 Score = 145 bits (366), Expect = 4e-35, Method: Composition-based stats. Identities = 64/362 (17%), Positives = 120/362 (33%), Gaps = 59/362 (16%) Query: 138 GVLLKKSAAWKKDRVALNQEVMAPEATKNFL-PLLDAVSRDFVSVLHRRIKKAGSGNYSG 196 G L+ L V++P + + V+R V L R+ + Sbjct: 70 GALVTLGGEAHTRMRRLFNAVLSPRVISRYEEATVTPVARRVVERLVRKER--------A 121 Query: 197 DISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFR 256 ++ DD +T+ +FG + + E I +M + + +P D Sbjct: 122 ELFDDFAISMPMGVTSALFGLPEERIAENDA--------LIRKM----IRSVVMPQD--- 166 Query: 257 LFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDI 316 V A A E I ++ + E Sbjct: 167 --------PVVVAEGRSAHAAMEAQLREIAEREVAHPSDTLLGEIARAIVAEGLGGVEAC 218 Query: 317 KANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPL 376 + V ++ G +TTS L L + + + LR Q L Sbjct: 219 EGVVLTLILGSYETTSWMLANLLVALLAHPDAMNQLR------------------QQPSL 260 Query: 377 LKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFD 436 L +I+E+ R + + R++ + + + A T++ +++ A + + PE FD Sbjct: 261 LPQAIEESTRWCSSAAGIVRFVEREATIGGETLAAGTILYLSLIARHYDEEIYPRPETFD 320 Query: 437 PTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTT 496 R L FG G+ C+G +A +E + + +LE F ++ V T Sbjct: 321 IHR--------RPVGMLNFGGGLHYCVGAPLARMEARVGVSLLLERFP-ALRADPTVQPT 371 Query: 497 FN 498 F+ Sbjct: 372 FS 373 >6GII-A nrPDB Length = 479 Score = 143 bits (361), Expect = 2e-34, Method: Composition-based stats. Identities = 38/244 (15%), Positives = 82/244 (33%), Gaps = 29/244 (11%) Query: 258 FRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIK 317 F + ++ +A + + + R I + L ++ + Sbjct: 240 FGRPSPEEQLAVAETVGQFWQFCGEVLEKMRRTADGPGWMRYSIRQQKLYPDVVTDSYLH 299 Query: 318 ANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLL 377 + + ++ +TT L + + V + A+ L+ Sbjct: 300 SMMQAIIVAAHETTVFATTNALKTLLEHETVWREICAD------------------PSLI 341 Query: 378 KASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDP 437 A+ +E LR + +R ++ + +P + + + + + F DPE FD Sbjct: 342 PAAAEECLRYNGPVAGWRRRTTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFFDI 401 Query: 438 TRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTF 497 R +L FG+G QCLGR + +EM I + + + H+ F Sbjct: 402 GR-------SNASEHLNFGYGAHQCLGRNLGRMEMQIMIEELSRR----LPHMRLAEQRF 450 Query: 498 NLIL 501 + + Sbjct: 451 DYLH 454 >3IVY-A nrPDB Length = 433 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 33/212 (15%), Positives = 67/212 (31%), Gaps = 36/212 (16%) Query: 286 WELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARN 345 E + K ++ + K+S ++ V + G +TT ++ + A + Sbjct: 228 AEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFAEH 287 Query: 346 LKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLR 405 + L +V + + E +R QR + D L Sbjct: 288 PDQWE-LYKKVRP-------------------ETAADEIVRWATPVTAFQRTALRDYELS 327 Query: 406 DYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGW-GVRQCLG 464 I V + + + F DP F+ R + ++GFG G C+G Sbjct: 328 GVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPNP--------HVGFGGTGAHYCIG 379 Query: 465 RRIAELEMTIFLINMLENFRVEIQHLSDVGTT 496 +A + + + + H+ D+ Sbjct: 380 ANLARMTINLIFNAVA-------DHMPDLKPI 404 >6G5O-A nrPDB Length = 399 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 37/227 (16%), Positives = 83/227 (36%), Gaps = 31/227 (13%) Query: 261 KTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSK-----MSFED 315 +W HV + D +++ Q + +Y +L +S+ ++ E+ Sbjct: 150 ISWGTHVFRSEGEALDGDKANILYHYIDEQIDRASENPGDDMYSVLLNSEFEGRKLTKEE 209 Query: 316 IKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVP 375 +K + AGG DT + + +A + + + LR E Sbjct: 210 VKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRKE------------------PE 251 Query: 376 LLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENF 435 + +++E +R + R + D + ++ + A + + + + R+ F +P Sbjct: 252 ITGRAVEEMIRYFSPLTQMGRVVTEDTHVCEHAVKADSRISLCWASANRDAAVFENPNEI 311 Query: 436 DPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLEN 482 R ++ ++GFG+ CLG A + I L + + Sbjct: 312 VLDRKVNP--------HVGFGFSHHNCLGATHARQILKILLQTLAQK 350 >2X9P-A nrPDB Length = 404 Score = 140 bits (352), Expect = 2e-33, Method: Composition-based stats. Identities = 64/425 (15%), Positives = 122/425 (28%), Gaps = 72/425 (16%) Query: 78 HVQNFQKYGPIYREKL-GNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRP 136 ++ Q GPI+R + E+ V ++ L E P + QY + P Sbjct: 31 LLRALQDRGPIHRVRTPAGDEAWLVTRHAELKQLLHDERI---GRTHPDPPSAAQYVRSP 87 Query: 137 IGVLLKKSAAWKKDRV--ALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNY 194 LL A + R A + ++ P + + + + L + + Sbjct: 88 FLDLLISDADAESGRRQHAETRRLLTPLFSARRVLEMQPKVEEAADTL---LDAFIAQGP 144 Query: 195 SGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDL 254 GD+ +L F + ++ +PP Sbjct: 145 PGDLHGELTV---------------------------PFALTV------LCEVIGVPPQR 171 Query: 255 FRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFE 314 T +A + L + + L D +++ + Sbjct: 172 RAELTTLLAGIAKLDDREGAVRAQDDLFGYVAGLVEHKRAEPGP--DIISRLNDGELTED 229 Query: 315 DIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLV 374 + +L G+D+ + + + +A + A L Sbjct: 230 RVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQ------------------RAAALADP 271 Query: 375 PLLKASIKETLRLHPISVTL--QRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDP 432 ++ +++E LR ++ RY D+ I A LV + + F P Sbjct: 272 DVMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAFTGP 331 Query: 433 ENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSD 492 E FD R T +L FG G+ C+G +A LE+ + L Sbjct: 332 EEFDAAR--------TPNPHLTFGHGIWHCIGAPLARLELRTMFTKLFTRLPELRPELPV 383 Query: 493 VGTTF 497 Sbjct: 384 EQLRL 388 >2UUQ-A nrPDB Length = 414 Score = 137 bits (346), Expect = 9e-33, Method: Composition-based stats. Identities = 47/230 (20%), Positives = 75/230 (32%), Gaps = 34/230 (14%) Query: 288 LRQKGSVHHDYRGILYRL----LGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMA 343 R++ D L GD+ + I A M+ GG DT + L + + Sbjct: 209 ERRRTEPADDAISHLVAAGVGADGDTAGTL-SILAFTFTMVTGGNDTVTGMLGGSMPLLH 267 Query: 344 RNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLV 403 R + +L L + +++E LRL L R D+ Sbjct: 268 RRPDQRRLL------------------LDDPEGIPDAVEELLRLTSPVQGLARTTTRDVT 309 Query: 404 LRDYMIPAKTLVQVAIYALGREPTFF-FDPENFDPTRWLSKDKNITYFRNLGFGWGVRQC 462 + D IPA V + + R+ + D D TR L F G C Sbjct: 310 IGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTR--------CPRNILTFSHGAHHC 361 Query: 463 LGRRIAELEMTIFLINMLENF-RVEIQHLSDVGTTFNLILMPEK-PISFT 510 LG A ++ + L +L E+ V + + + P P T Sbjct: 362 LGAAAARMQCRVALTELLARCPDFEVAESRIVWSGGSYVRRPLSVPFRVT 411 >3WEC-A nrPDB Length = 419 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 41/236 (17%), Positives = 77/236 (32%), Gaps = 29/236 (12%) Query: 267 VAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAG 326 D + + F + R + G ++S ++I A + Sbjct: 194 KEVADRRSAAIEESIDYFRTLATSGNAPEGLVRRLSEVSHGGDQLSVDEIAATCLLITVA 253 Query: 327 GVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLR 386 G +TTS T+ L +R+ + +RA ++ ++ E LR Sbjct: 254 GQETTSNTIGNMLITFSRHADQFEQVRA------------------NPQFIENAVAEVLR 295 Query: 387 LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKN 446 P + R + D + I V V + + R + F TR Sbjct: 296 FEPPAHEAGRIALEDCEVSGANITKGDAVMVLLASGNR--EAVERGDTFSVTR------- 346 Query: 447 ITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILM 502 +L +G G+ CLG +A + FL + + +R I+ + + L Sbjct: 347 -PDVSSLSYGRGIHHCLGSALANSMLQHFLRELSQRYR-SIEVAEPINYKPGMGLR 400 >2WIY-A nrPDB Length = 394 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 43/206 (20%), Positives = 76/206 (36%), Gaps = 25/206 (12%) Query: 290 QKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQ 349 ++ + L +++ + A + A G + + AR +V Sbjct: 197 KRVNPGDGLADSLLDAARAGEITESEAIATILVFYAVGHMAIGYLIASGIELFARRPEVF 256 Query: 350 DMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMI 409 R + A A I E +R+ P ++ R+ D+ + +I Sbjct: 257 TAFRNDESAR------------------AAIINEMVRMDPPQLSFLRFPTEDVEIGGVLI 298 Query: 410 PAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAE 469 A + ++ I A R+P F DP+ FD TR + +N L FG G C G+ I+ Sbjct: 299 EAGSPIRFMIGAANRDPEVFDDPDVFDHTRPPAASRN------LSFGLGPHSCAGQIISR 352 Query: 470 LEMTIFLINMLENF-RVEIQHLSDVG 494 E T + E + R+E+ V Sbjct: 353 AEATTVFAVLAERYERIELAEEPTVA 378 >3OO3-A nrPDB Length = 384 Score = 136 bits (341), Expect = 3e-32, Method: Composition-based stats. Identities = 44/269 (16%), Positives = 91/269 (33%), Gaps = 39/269 (14%) Query: 245 VPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELR--QKGSVHHDYRGIL 302 L +P D + + + + + N+ L ++ G++ Sbjct: 144 CEFLGVPRDDQAELSRMIRESRESRLPRQRTLSGLGIVNYTKRLTSGKRRDPGDGMIGVI 203 Query: 303 YRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQ 362 R G +++S E++ L + + L + + + +LR Sbjct: 204 VREHG-AEISDEELAGLAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLR--------- 253 Query: 363 AQGDMATMLQLVPLLKASIKETLRLHPISVT-LQRYLVNDLVLRDYMIPAKTLVQVAIYA 421 + L+ ++ +E LR I R + D+ + I A ++ ++ A Sbjct: 254 ---------EKPELIDSATEEVLRHASIVEAPAPRVALADVRMAGRDIHAGDVLTCSMLA 304 Query: 422 LGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLE 481 R P + FD TR ++ FG G+ C+G +A L++ + L ++ Sbjct: 305 TNRAP-----GDRFDITR--------EKATHMAFGHGIHHCIGAPLARLQLRVALPAVVG 351 Query: 482 NFRVEIQHLSDVGTTFNLILMPEKPISFT 510 F L +L P +P F Sbjct: 352 RF----PSLRLAVPEEDLRFKPGRPAPFA 376 >2NZA-A nrPDB Length = 413 Score = 135 bits (339), Expect = 5e-32, Method: Composition-based stats. Identities = 74/491 (15%), Positives = 145/491 (29%), Gaps = 98/491 (19%) Query: 34 TGEGAGISTRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKL 93 T E ++ +SP P D L+L + + GP+ R +L Sbjct: 2 TQETTTLTGQSP------PPVRDWPALDLD--------GPEFDPVLAELMREGPLTRVRL 47 Query: 94 --GNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQ-RPIGVLLKKSAAWKKD 150 G + +DV + +++ RP + + Sbjct: 48 PHGEGWAWLATRYDDVKAITNDPRFGRAEVTQRQITRLAPHFKPRPGSLAFADQPDHNRL 107 Query: 151 RVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESI 210 R A+ ATK P + V + + D+ + + Sbjct: 108 RRAV-AGAFTVGATKRLRPRAQEILDGLVDGIL-------AEGPPADLVERV-------- 151 Query: 211 TNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAW 270 + F A+ ++ +P R +W + + Sbjct: 152 -------------------LEPFPIAVVS------EVMGVPAADRE--RVHSWTRQIIST 184 Query: 271 DVIFSKADIYTQNFYWELRQKGSV-----HHDYRGILYRLLGDSKMSFEDIKANVTEMLA 325 A+ + Y + + D +L +G ++ + + Sbjct: 185 SGGAEAAERAKRGLYGWITETVRARAGSEGGDVYSMLGAAVGRGEVGETEAVGLAGPLQI 244 Query: 326 GGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETL 385 GG + + + LY + ++ +R A ++ E L Sbjct: 245 GG-EAVTHNVGQMLYLLLTRRELMARMRERPGAR------------------GTALDELL 285 Query: 386 RL--HPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSK 443 R H SV L R + D+ + I A V V+ A R+P F DP+ D R + Sbjct: 286 RWISHRTSVGLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDRDPNP 345 Query: 444 DKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLEN---FRVEIQHLSDVGTTFNLI 500 +L +G G C G +A ++ + + +LE R+ + +I Sbjct: 346 --------HLAYGNGHHFCTGAVLARMQTELLVDTLLERLPGLRLAVPAEQVAWRRKTMI 397 Query: 501 LMPEKPISFTF 511 P + + T+ Sbjct: 398 RGP-RTLPCTW 407 >1WIY-A nrPDB Length = 389 Score = 134 bits (337), Expect = 1e-31, Method: Composition-based stats. Identities = 78/420 (18%), Positives = 134/420 (31%), Gaps = 73/420 (17%) Query: 93 LGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRV 152 L + DPE V +EG F + A + R G+L +WK+ R Sbjct: 38 LPRFPLALIFDPEGVEGALLAEGTTKATF---QYRALSRLTGR--GLLTDWGKSWKEARK 92 Query: 153 ALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITN 212 AL + P++ + + ++ + F + D+ ++ + + Sbjct: 93 ALKDPFL-PKSVRGYREAMEEEAWAFF----GEWR-----GEERDLDHEMLALSLRLLGR 142 Query: 213 VIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDV 272 +FG+ A+ + + L + KD Sbjct: 143 ALFGKPLSPSLAE---------HALKALDRIMAQTRSPLALLDLAAEARFRKDR------ 187 Query: 273 IFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTS 332 + + VH S + E + +L G +T + Sbjct: 188 ----------GALYREAEALIVHPPL----------SHLPRERALSEAVTLLVAGHETVA 227 Query: 333 MTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISV 392 L W ++ Q + AA +E LRL+P + Sbjct: 228 SALTWSFLLLSHRPDWQKRVAESEEAALAA------------------FQEALRLYPPAW 269 Query: 393 TLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRN 452 L R L L+L + +P T + ++ Y R +F + E F P R+L+ ++ R Sbjct: 270 ILTRRLERPLLLGEDRLPQGTTLVLSPYVTQR--LYFPEGEAFQPERFLA-ERGTPSGRY 326 Query: 453 LGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFW 512 FG G R CLGR A LE I L FR++ V + L PE + Sbjct: 327 FPFGLGQRLCLGRDFALLEGPIVLRAFFRRFRLDPLPFPRV--LAQVTLRPEGGLPARPR 384 >6G71-A nrPDB Length = 405 Score = 133 bits (335), Expect = 2e-31, Method: Composition-based stats. Identities = 69/415 (16%), Positives = 118/415 (28%), Gaps = 65/415 (15%) Query: 76 LHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPN-----PERFLIPPWVAYH 130 +H +Q PI+ +V PE L S + Sbjct: 14 VHLADLYQNPFPIFERLRSESPVAWV--PEAGRYLITSYSGVLAADVDQTTFSANEKKSL 71 Query: 131 QYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAG 190 +L K + +R A + P K + F R + Sbjct: 72 MLRAMGHSMLRKDDPDHQVERRAWQPS-LKPGTVKKVWK------QKFAENADRYLDAYI 124 Query: 191 SGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNL 250 D + G E + QR+ + + Sbjct: 125 DAGSGSDFMQGFAAPFVAENLRALIG-----FENASEADLQRWSQTL-------IDGAGN 172 Query: 251 PPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSK 310 PD W + D I + + Q G L R D + Sbjct: 173 YPDD-----PDVWAKAKQSSDEIDAALEEMIQ------WHSGRPGDSLLSYLLRS-ADYQ 220 Query: 311 MSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATM 370 M E I++N+ + GG++ L + + K +++ Sbjct: 221 MPLESIRSNIKMTIGGGLNEPRDVLGVSTLALLSSSKQLELV------------------ 262 Query: 371 LQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFF 430 L+ L A +E++R + R V D L Y IP + + I + R+ + + Sbjct: 263 LRDPKLWGAVFEESIRWVAPIGMVPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWS 322 Query: 431 DPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMT-IFLINMLENFR 484 DP+ FD R +L FG GV CLG A ++ + L + + Sbjct: 323 DPDRFDIER--------GSEAHLAFGKGVHVCLGAWAARSQVADVGLPALFSRLK 369 >5HH3-A nrPDB Length = 397 Score = 131 bits (330), Expect = 6e-31, Method: Composition-based stats. Identities = 55/350 (15%), Positives = 101/350 (28%), Gaps = 73/350 (20%) Query: 138 GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGD 197 G L + + A + F P ++ V +D + + D Sbjct: 89 GFLTQYDPPEHTRLRRMVAPAFAVRRMQKFQPQVERVVQDSLDAIEAL-------GGPVD 141 Query: 198 ISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRL 257 ++ + F L +P D Sbjct: 142 FVPRFG-WSVATTATCDF--------------------------------LGIPRDDQAD 168 Query: 258 FRTKTWKDHVAAWDVIFSKADIYTQNFYWE--LRQKGSVHHDYRGILYRLLGDSKMSFED 315 + A + + R + D G++ R GD +++ + Sbjct: 169 LARSLHASRTERSGKRRTAAGNKFMTYMNKMTARTRRDPGDDMFGVVVREYGD-EITDAE 227 Query: 316 IKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVP 375 + ++ G D + L + MA + + +LR + Sbjct: 228 LTGVAAFVMGAGADQVARFLAAGAWLMADDPEQFALLREKPDTV---------------- 271 Query: 376 LLKASIKETLRLHPI-SVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDP-E 433 + E +R T R +D+ + D++I A V ++ A R F P + Sbjct: 272 --PDWLDEVIRYLTTDEKTHPRVATDDVRIGDHLIKAGDTVTCSLLAANR--RNFPRPED 327 Query: 434 NFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 FD TR +L FG G+ CLGR +AEL + + F Sbjct: 328 RFDITR--------VRPEHLAFGHGIHHCLGRSLAELVFRTAIPALAHRF 369 >6BLD-A nrPDB Length = 419 Score = 127 bits (319), Expect = 1e-29, Method: Composition-based stats. Identities = 34/233 (14%), Positives = 71/233 (30%), Gaps = 30/233 (12%) Query: 281 TQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLY 340 R+ + ++ + +++ D+ A + G DTT T+ L Sbjct: 215 VAASLAAERRDRPGDDLFSALVNAEVDGDRLADADVAAFFVLLAVAGNDTTRQTISHGLK 274 Query: 341 EMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVN 400 + + L A+ + +++E +R +T +R Sbjct: 275 ALTDFPSQKAWLLADFDTR-----------------IGTAVEELVRWATPVMTFRRTAAA 317 Query: 401 DLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVR 460 D L +I A V + + + F PE D +R + Sbjct: 318 DFELGGQLIRAGEKVVMFYASGNWDEDAFCHPERLDLSRSPNPHVGFGGGGVH------- 370 Query: 461 QCLGRRIAELEMTIFLINMLENFRVEIQHLS--DVGTTFNLILMPEKPISFTF 511 CLG +A ++ +L V++ + D + + + TF Sbjct: 371 FCLGAHLARAQLRAIFGELL----VQLPDIQAGDPVYVPGNFVHAIRSMPCTF 419 >3BUJ-A nrPDB Length = 397 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 38/176 (21%), Positives = 65/176 (36%), Gaps = 26/176 (14%) Query: 296 HDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAE 355 D ++ MS +I + V + G +T + + + + + D+LR Sbjct: 203 EDLLALMLDAHDRGLMSRNEIVSTVVTFIFTGHETVASQVGNAVLSLLAHPDQLDLLRR- 261 Query: 356 VLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLV 415 LL +++E LR P + R L D+ LR + +V Sbjct: 262 -----------------RPDLLAQAVEECLRYDPSVQSNTRQLDVDVELRGRRLRRDDVV 304 Query: 416 QVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELE 471 V A R+P + P++FD R + FG G+R CLG +A + Sbjct: 305 VVLAGAANRDPRRYDRPDDFDIERDPVPS--------MSFGAGMRYCLGSYLARTQ 352 >4FB2-A nrPDB Length = 398 Score = 125 bits (314), Expect = 4e-29, Method: Composition-based stats. Identities = 43/265 (16%), Positives = 95/265 (35%), Gaps = 35/265 (13%) Query: 247 MLNLPPDLFRLFRTKTWK-DHVA--AWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILY 303 +L LPP+ +R W HV + R+ + ++ Sbjct: 150 LLGLPPEDGDTYRRWVWAITHVENPEEGAEIFAELVAHARTLIAERRTNPGNDIMSRVIM 209 Query: 304 RLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQA 363 + +S +D+ T +L GG+D T+ L + +A +++++ L Sbjct: 210 SKIDGESLSEDDLIGFFTILLLGGIDNTARFLSSVFWRLAWDIELRRRL----------- 258 Query: 364 QGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALG 423 + L+ ++ E LR + + + R + ++ + D + + Sbjct: 259 -------IAHPELIPNAVDELLRFYGPA-MVGRLVTQEVTVGDITMKPGQTAMLWFPIAS 310 Query: 424 REPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 R+ + F P+N R T R+L G G+ +CLG + +E + + L+ Sbjct: 311 RDRSAFDSPDNIVIER--------TPNRHLSLGHGIHRCLGAHLIRVEARVAITEFLKRI 362 Query: 484 -RVEIQHLSD----VGTTFNLILMP 503 + + +G ++ +P Sbjct: 363 PEFSLDPNKECEWLMGQVAGMLHVP 387 >5EX8-A nrPDB Length = 424 Score = 125 bits (314), Expect = 4e-29, Method: Composition-based stats. Identities = 54/369 (14%), Positives = 102/369 (27%), Gaps = 75/369 (20%) Query: 138 GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGD 197 G L + + + + F P ++ + +D + + D Sbjct: 116 GFLTQYDPPEHTRLRRMVVPAFSHRRMQKFRPRVEQIVQDSLDTIESL-------GGPVD 168 Query: 198 ISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRL 257 +A + F L +P D Sbjct: 169 FVPHFG-WAIATPATCDF--------------------------------LGIPRDDQAD 195 Query: 258 FRTKTWKDHVAAWDVIFSKADIYTQNFYWE--LRQKGSVHHDYRGILYRLLGDSKMSFED 315 D + A + + + + D GI+ R GD+ ++ + Sbjct: 196 LARILLASRTDRSDKRRTAAGNKFMTYMKQHVAQSRRGSGDDLFGIVGRENGDA-ITDAE 254 Query: 316 IKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVP 375 + ++ D + L + M +LR + Sbjct: 255 LTGVAAFVMGAAADQVARLLAAGAWLMVEQPAQFALLREKPETV---------------- 298 Query: 376 LLKASIKETLRLHPI-SVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPEN 434 + ET+R T R D+ + + ++ A V ++ A R P + + Sbjct: 299 --PEWLDETMRYLTTDEKTHPRVATQDVRIGNQLVKAGDTVTCSLLAANR-PNYPSAEDE 355 Query: 435 FDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVG 494 FD TR +L FG G+ CLGR +AEL + + + F L Sbjct: 356 FDITR--------EKAEHLAFGHGIHHCLGRAMAELMFKVSIPALAHRF----PTLRLAD 403 Query: 495 TTFNLILMP 503 + L P Sbjct: 404 PQREITLGP 412 >2IJ7-A nrPDB Length = 396 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 45/266 (16%), Positives = 94/266 (35%), Gaps = 33/266 (12%) Query: 223 EEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQ 282 E F D + H +L +P + +++ D I + + + Sbjct: 127 EGAPADLRNDFADPLATALH--CKVLGIPQEDGPKLFRSLSIAFMSSADPIPAAKINWDR 184 Query: 283 N--FYWELRQKGSVHHDYRGILYRLLGDSKMSF--EDIKANV-TEMLAGGVDTTSMTLQW 337 + + + + ++ G L RL D S +++ A + GV +T L Sbjct: 185 DIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTT 244 Query: 338 HLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLH-PISVTLQR 396 L + + +++++L + L+ A ++E LR++ + L R Sbjct: 245 ALISLIQRPQLRNLLH------------------EKPELIPAGVEELLRINLSFADGLPR 286 Query: 397 YLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFG 456 D+ + D ++ LV V + +P F +P + + R +L FG Sbjct: 287 LATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDR-------PNPTSHLAFG 339 Query: 457 WGVRQCLGRRIAELEMTIFLINMLEN 482 G C G + I + +L+ Sbjct: 340 RGQHFCPGSALGRRHAQIGIEALLKK 365 >5KYO-A nrPDB Length = 430 Score = 116 bits (290), Expect = 3e-26, Method: Composition-based stats. Identities = 61/377 (16%), Positives = 119/377 (31%), Gaps = 72/377 (19%) Query: 113 SEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLD 172 E + L+P A Y P L + R LN+ + P+ L ++ Sbjct: 99 FERFSNHTVLVPKETAGEAYRLIP---LSLDPPEHRPFRSLLNEN-LGPKP----LRPIE 150 Query: 173 AVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQR 232 V D L + G N++ + ++ L F R L P+ + Sbjct: 151 QVVTDLAVSLIEGFRPKGRCNFTHEFAEQLPVRIF---------MRIVDLPVEDLPKLKH 201 Query: 233 FIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKG 292 D + S+P+ ++ R E R+ Sbjct: 202 LADQYTRPD-GSIPLDDVTKQFREYLRPVI------------------------EARRIK 236 Query: 293 SVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDML 352 ++ +G ++ + + ++L GG+DT L + +A++ ++ + Sbjct: 237 PGEDMISRMINGEVGGRPLTDIEAENICIQVLVGGLDTVVNMLGFTFSHLAKDHALRRAI 296 Query: 353 RAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAK 412 A+ L+ ++ E R P+ + R ++ D ++ A Sbjct: 297 AAD------------------PSLIDDALLEFFRRFPVVSS-AREVLRDQEFEGVLLKAG 337 Query: 413 TLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEM 472 +V + + DP F R ++ FG G C G +A +EM Sbjct: 338 DMVMAPTVVVAMDDARNEDPLEFRLGR--------KARQHSTFGKGSHTCPGAHLARMEM 389 Query: 473 TIFLINMLEN---FRVE 486 + L FR+E Sbjct: 390 KVVLREWFARIPEFRIE 406 >5D3U-A nrPDB Length = 427 Score = 112 bits (281), Expect = 3e-25, Method: Composition-based stats. Identities = 33/175 (18%), Positives = 59/175 (33%), Gaps = 28/175 (16%) Query: 309 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMA 368 + + + + A TT +L ARN + + A+ Sbjct: 253 PEQTVHQLALVFIALFAP---TTPGSLSSGTLAFARNPRQVERFLADQACV--------- 300 Query: 369 TMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTF 428 + E LR + + R D+ + I A + + + + R+ Sbjct: 301 ---------DNTANEVLRYNASNQFTWRVAAKDVEMGGVRIEAGQTLALFLGSANRDANM 351 Query: 429 FFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 483 F P +FD R R+L FG GV CL ++ L++ F + +L F Sbjct: 352 FERPNDFDLDR-------PNSARHLSFGQGVHACLAAQLISLQLKWFYVALLNRF 399 >2IAG-A nrPDB Length = 482 Score = 109 bits (272), Expect = 3e-24, Method: Composition-based stats. Identities = 94/516 (18%), Positives = 181/516 (35%), Gaps = 77/516 (14%) Query: 43 RSPRPFNEIPSPGDNGWLN-LYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYV 101 R+ RP G WL F ++ + + +K+G I+ +G + Sbjct: 1 RTRRPGEPPLDLGSIPWLGYALDFGKDAAS-----FLTRMKEKHGDIFTILVGGRYVTVL 55 Query: 102 IDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKK----------SAAWKKDR 151 +DP + W + + L + S + +K R Sbjct: 56 LDP--------------HSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKAR 101 Query: 152 VALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESIT 211 + L + L +A+ + +VL +AGSG + + D + F + Sbjct: 102 MKLTL------LHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGY 155 Query: 212 NVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWD 271 ++G L +AQ + + +FHT + L P L R + KDH+ + Sbjct: 156 LTLYGIEA--LPRTHESQAQDRVHS-ADVFHTFRQLDRLLPKLARGSLSVGDKDHMCS-- 210 Query: 272 VIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTT 331 V + + + Y L + +M +A V ++ Sbjct: 211 VKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEM---QARALVLQL-WATQGNM 266 Query: 332 SMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGD-------MATMLQLVPLLKASIKET 384 W L + +N + +R E+ + QA+ +L P+L + + E+ Sbjct: 267 GPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSES 326 Query: 385 LRLHPISVTLQRYLVNDLVL-----RDYMIPAKTLVQVAI-YALGREPTFFFDPENFDPT 438 LRL + R +V DL + R++ + + + + R+P + DPE F Sbjct: 327 LRLTAAPF-ITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYN 385 Query: 439 RWLSKDKNIT----------YFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQ 488 R+L+ D + N+ +G G CLGR A + F+ +L + +E+ Sbjct: 386 RFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELI 445 Query: 489 HLSDVGTTFNL------ILMPEK--PISFTFWPFNQ 516 + F+L ++ PE P+ + P + Sbjct: 446 NADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRPHHH 481 >6FYJ-A nrPDB Length = 421 Score = 109 bits (271), Expect = 4e-24, Method: Composition-based stats. Identities = 64/471 (13%), Positives = 150/471 (31%), Gaps = 72/471 (15%) Query: 44 SPRPFNEIPSPGDNGWLNLYHFWR--ETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYV 101 S N++P + WR E G + I+ +L +++ + Sbjct: 2 SMSNINQMPREE-----GIDSTWRLMEEGYMYILNRRHSFNSD---IFETRLLGKKAICM 53 Query: 102 IDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAP 161 E + + +E +R P + + GV K R + +M+P Sbjct: 54 GGKEAAEIFYDTEK--FKRKDAAPNRVVQTLFGK-NGVQALDGQTHK-HRKEMFMSIMSP 109 Query: 162 EATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGM 221 + L L +++ + + ++ + ++ + Sbjct: 110 DE----LEKLTDITKKQWEIAVDKWEQMDK----VILYEEAKEIMCRTACQWA------- 154 Query: 222 LEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAW--DVIFSKADI 279 V E +R + MF ++ + L + +++ W ++I D Sbjct: 155 GVPVQENEVKRLTKNLGAMFESAAAV-----GLKHWLG-RHARNYEEIWIEELIDRVRDG 208 Query: 280 YTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHL 339 K S + D G L D++ + ++ + ++A ++ + + Sbjct: 209 KVNPPENTTLHKFSWYRDLEGNLL----DTETAAVEVINILRPIVA-----IAIFINFIA 259 Query: 340 YEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLV 399 + + ++ L++ + ++E R +P + + Sbjct: 260 LALHHYPEEKEKLKSG-----------------DKKYSQMFVQEVRRFYPFFPFVVALVK 302 Query: 400 NDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGV 459 D + Y TL + +Y +P + +P+ F P R+ + + F + G G Sbjct: 303 KDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRFAKWEGS--PFSFIPQGGGD 360 Query: 460 ----RQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKP 506 +C G + M + L + E+ D +F++ MP P Sbjct: 361 YFMGHRCAGEWVTIEVMKVSLDYLTNRMDYEV---PDQDLSFSMASMPSIP 408 >2QBO-A nrPDB Length = 421 Score = 108 bits (270), Expect = 5e-24, Method: Composition-based stats. Identities = 32/215 (14%), Positives = 71/215 (33%), Gaps = 28/215 (13%) Query: 287 ELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNL 346 E R++ + + ++ ++ K +L G+DT L + + +A++ Sbjct: 210 EQRRQKPGTDAISIVANGQVNGRPITSDEAKRMCGLLLVVGLDTVVNFLSFSMEFLAKSP 269 Query: 347 KVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD 406 + + L ++ + A+ +E LR + R L +D Sbjct: 270 EHRQEL------------------IERPERIPAACEELLRRFSLVAD-GRILTSDYEFHG 310 Query: 407 YMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRR 466 + + + G + P + D +R + FG G CLG+ Sbjct: 311 VQLKKGDQILLPQMLSGLDERENACPMHVDFSR--------QKVSHTTFGHGSHLCLGQH 362 Query: 467 IAELEMTIFLINMLENF-RVEIQHLSDVGTTFNLI 500 +A E+ + L L I + + ++ Sbjct: 363 LARREIIVTLKEWLTRIPDFSIAPGAQIQHKSGIV 397 >2ZQJ-A nrPDB Length = 417 Score = 104 bits (260), Expect = 7e-23, Method: Composition-based stats. Identities = 65/464 (14%), Positives = 138/464 (29%), Gaps = 65/464 (14%) Query: 54 PGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGP-IYREKLGNVESVYVIDPEDVALLFK 112 P D N +E +L ++Y +++ +L + + E + + Sbjct: 6 PHDKSLDNSLTLLKEG-----YLFIKNRTERYNSDLFQARLLGKNFICMTGAEAAKVFYD 60 Query: 113 SEGPNPERFLIPPWVAYHQYYQRPIGVLLKKS--AAWKKDRVALNQEVMAPEATKNFLPL 170 ++ + L + + GV + + R L +M P K L Sbjct: 61 TDRFQRQNALPK------RVQKSLFGVNAIQGMDGSAHIHRKMLFLSLMTPPHQKRLAEL 114 Query: 171 LDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEA 230 + + + + + ++ + E V A Sbjct: 115 M-------TEEWKAAVTRWEKADEVV-LFEEAKEILCRVACYWA---GVPLKETEVKERA 163 Query: 231 QRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQ 290 FID + F P R + W + + D + E+ Sbjct: 164 DDFIDMVDA-FGAVGPRHW--KGRRARPRAEEWIEVMIE-DARAGLLKTTSGTALHEMAF 219 Query: 291 KGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQD 350 DS+M+ ++ + ++A S L + + + K ++ Sbjct: 220 HTQEDGSQL--------DSRMAAIELINVLRPIVA-----ISYFLVFSALALHEHPKYKE 266 Query: 351 MLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIP 410 LR+ R + ++E R +P L + D V + Sbjct: 267 WLRSGNSRER-----------------EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFK 309 Query: 411 AKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGV----RQCLGRR 466 T V + +Y +P + P+ F P R+ +++N+ F + G G +C G Sbjct: 310 KGTSVLLDLYGTNHDPRLWDHPDEFRPERFAEREENL--FDMIPQGGGHAEKGHRCPGEG 367 Query: 467 IAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFT 510 I M L ++ ++ S + + +PE + Sbjct: 368 ITIEVMKASLDFLVHQIEYDVPEQSLHYSLARMPSLPESGFVMS 411 >5YHJ-A nrPDB Length = 413 Score = 104 bits (259), Expect = 9e-23, Method: Composition-based stats. Identities = 59/472 (12%), Positives = 141/472 (29%), Gaps = 73/472 (15%) Query: 54 PGDNGWLNLYHFWRETGTHKVHLHHVQNFQKY-GPIYREKLGNVESVYVIDPEDVALLFK 112 P G + F RE +L + + I+ +L + + E + + Sbjct: 6 PKQEGLDHSVDFLREG-----YLFVANRRKSFQSNIFESRLLGERVICLGGEEAAEVFY- 59 Query: 113 SEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLD 172 + R P + GV + R + +M E L L Sbjct: 60 -DANKFTRQDAAPKRLLKTLFGEG-GVQTLDGSEH-THRKQMFMSLMTKENIDRLLRLT- 115 Query: 173 AVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQR 232 +R + + D +++ + + E + Sbjct: 116 ----------YREWNQIERMGEEIVLYDIAQEVLMKAVC-------EWSGVPLAKEEVGK 158 Query: 233 FIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKG 292 + + +F + + + A S A+++ + E+R Sbjct: 159 RTEEMRLLFESGTSL-----------GPTYLQGRKAR-----SSAEVWIRQMVKEVRSNR 202 Query: 293 SVHHDYRGILY---RLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQ 349 + +++ + ++ E++ A + S+ + + + + + V+ Sbjct: 203 LLPNEHTALYEFSWHRDESGELLPEEVVAVEVLNILRPTVAISVYVLFTVLALHQFPDVK 262 Query: 350 DML-RAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYM 408 + + R EV ++E R +P + D Y Sbjct: 263 EQVERGEVSKTE-------------------FVQEVRRFYPFFPVAAARVKTDFEWDGYA 303 Query: 409 IPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGV----RQCLG 464 P TL + +Y + + + +P+ FDP+R+ KD + F + G G +C G Sbjct: 304 FPEGTLTLLDLYGTNHDVSIWTEPDRFDPSRF--KDWKESPFNFIPQGGGDVDFGHRCAG 361 Query: 465 RRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQ 516 + + + + + + + ++ +P+ + T NQ Sbjct: 362 EHVTIAILAQVIELFTKEYAYTVPPQDLSYSFVDMPSLPKSKLRLTHLTRNQ 413 >5OMS-A nrPDB Length = 409 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 24/123 (19%), Positives = 40/123 (32%), Gaps = 9/123 (7%) Query: 360 RHQAQGDMATMLQLVPLLKASIKETLRLHPISV-TLQRYLVNDLVLRDYMIPAKTLVQVA 418 + ++ L+ +I E LR R + + +PA T V ++ Sbjct: 263 LFSRPEQLEEVVDDPTLIPRAIAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTPVMLS 322 Query: 419 IYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLIN 478 + + + P +D R +L FG G C G A M I L Sbjct: 323 YGSANHDTGKYEAPSQYDLHR--------PPLPHLAFGAGNHACAGIYFANHVMRIALEE 374 Query: 479 MLE 481 + E Sbjct: 375 LFE 377 >3NV6-A nrPDB Length = 452 Score = 99.1 bits (245), Expect = 5e-21, Method: Composition-based stats. Identities = 32/208 (15%), Positives = 76/208 (36%), Gaps = 30/208 (14%) Query: 287 ELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNL 346 R G ++ + +++ + + ++ +L GG+DT L + + +AR+ Sbjct: 251 RARVGGDGDDLITLMVNSEINGERIAHDKAQGLISLLLLGGLDTVVNFLSFFMIHLARHP 310 Query: 347 KVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD 406 ++ LR++ + L++ + +E R P+ + R + D + Sbjct: 311 ELVAELRSDP-----------------LKLMRGA-EEMFRRFPVV-SEARMVAKDQEYKG 351 Query: 407 YMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRR 466 + ++ + G + +P D +R + FG G +C G Sbjct: 352 VFLKRGDMILLPTALHGLDDAANPEPWKLDFSR--------RSISHSTFGGGPHRCAGMH 403 Query: 467 IAELEMTIFLINMLEN---FRVEIQHLS 491 +A +E+ + L L+ F + Sbjct: 404 LARMEVIVTLEEWLKRIPEFSFKEGETP 431 >2RCM-A nrPDB Length = 495 Score = 97.2 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 65/489 (13%), Positives = 152/489 (31%), Gaps = 64/489 (13%) Query: 38 AGISTRSPRPFNEIPSPGDNGWLNLYH----FWRETGTHKVHLHHVQNFQKYGP-IYREK 92 A + P IP + ++ + G + +KY +YR Sbjct: 17 ATRTGSKDLPIRNIPGNYGLPIVGPIKDRWDYFYDQGAEEF---FKSRIRKYNSTVYRVN 73 Query: 93 L-------GNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSA 145 + N + V ++D + +LF + + L ++ + + + Sbjct: 74 MPPGAFIAENPQVVALLDGKSFPVLFDVDKVEKKDLLTGTYMPSTELTGGYRILSYLDPS 133 Query: 146 AWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRF 205 K +++ + + P A + L + + G D Sbjct: 134 EPKHEKLKNLLFFLLKSSRNRIFPEFQATYSELFDSLEKELSLKGKA----DFGGSSDGT 189 Query: 206 AFESITNVIFGER---QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPP--DLFRLFRT 260 AF + +G + + + + ++ + +P + P F L Sbjct: 190 AFNFLARAFYGTNPADTKLKADAPGLITKWVLFNLHPLLSIGLPRVIEEPLIHTFSLPPA 249 Query: 261 KTWKDHVAAWDVIFS-KADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKAN 319 D+ ++ +I + + ++ + H+ + G K+ F ++ Sbjct: 250 LVKSDYQRLYEFFLESAGEILVEADKLGISREEATHNLLFATCFNTWGGMKILFPNMVKR 309 Query: 320 VTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMAT-MLQLVPLLK 378 + G +V + L E+ + G++ ++ + L K Sbjct: 310 IGR---AGH------------------QVHNRLAEEIRSVIKSNGGELTMGAIEKMELTK 348 Query: 379 ASIKETLRLHPISVTLQRYLVNDLVLRDY----MIPAKTLVQVAIYALGREPTFFFDPEN 434 + + E LR P DLV+ + + A ++ R+P F + Sbjct: 349 SVVYECLRFEPPVTAQYGRAKKDLVIESHDAAFKVKAGEMLYGYQPLATRDPKIFDRADE 408 Query: 435 FDPTRWLSKDKNITYFRNLGFGWGV---------RQCLGRRIAELEMTIFLINMLEN--- 482 F P R++ ++ R++ + G +QC G+ L +F+I + Sbjct: 409 FVPERFVGEEGE-KLLRHVLWSNGPETETPTVGNKQCAGKDFVVLVARLFVIEIFRRYDS 467 Query: 483 FRVEIQHLS 491 F +E+ Sbjct: 468 FDIEVGTSP 476 >4C9K-A nrPDB Length = 421 Score = 96.0 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 43/208 (20%), Positives = 78/208 (37%), Gaps = 30/208 (14%) Query: 287 ELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNL 346 R+ GS IL + M + V+ +L GG+DT L + + ++R+ Sbjct: 217 AARRGGSGTDLITRILNVEIDGKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSRHP 276 Query: 347 KVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRD 406 + +R E L L+ ++E R + + RY+V+D+ Sbjct: 277 ETVAEMRREPLK------------------LQRGVEELFRRFAVV-SDARYVVSDMEFHG 317 Query: 407 YMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRR 466 M+ L+ + G + DP D +R + F G +C G Sbjct: 318 TMLKEGDLILLPTALHGLDDRHHDDPMTVDLSR--------RDVTHSTFAQGPHRCAGMH 369 Query: 467 IAELEMTIFLINMLEN---FRVEIQHLS 491 +A LE+T+ L L FR++ + + Sbjct: 370 LARLEVTVMLQEWLARIPEFRLKDRAVP 397 >5M0P-A nrPDB Length = 428 Score = 94.5 bits (233), Expect = 9e-20, Method: Composition-based stats. Identities = 59/394 (14%), Positives = 113/394 (28%), Gaps = 76/394 (19%) Query: 88 IYREK-LGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAA 146 +++ K LG V V E + + ++ E L + G + Sbjct: 41 VFQTKALGGKPFVVVTGKEGAEMFYNNDVVQREGMLPK------RIVNTLAGKGAIHTVD 94 Query: 147 WKKD--RVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFR 204 KK R AL +M R+ L + +I + Sbjct: 95 GKKHVDRKALFMSLMTEGNLN--------YVRELTRTLWHANTQRMESMDEVNIYRE--- 143 Query: 205 FAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWK 264 + G R ++ I+ I + F K Sbjct: 144 ---SIVLLTKVGTRWAGVQAPPED-----IERIATDMDIMIDSFRALGGAF--------K 187 Query: 265 DHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLG---------DSKMSFED 315 + A+ + D + +KG++H LY DS+ D Sbjct: 188 GYKASKEARRRVEDWLEEQIIE--TRKGNIHPPEGTALYEFAHWEDYLGNPMDSRTCAID 245 Query: 316 IKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVP 375 + ++A + + + L+ M N ++ +++E Sbjct: 246 LMNTFRPLIA-----INRFVSFGLHAMNENPITREKIKSE------------------PD 282 Query: 376 LLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENF 435 +E R +P L D+ + IPA + + +Y + + + DP F Sbjct: 283 YAYKFAQEVRRYYPFVPFLPGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEF 342 Query: 436 DPTRWLSKDKNITYFRNLGFGWGV----RQCLGR 465 P R+ + D + F + G G +C G Sbjct: 343 RPERFETWDGS--PFDLIPQGGGDYWTNHRCAGE 374 >3B98-A nrPDB Length = 475 Score = 88.7 bits (218), Expect = 5e-18, Method: Composition-based stats. Identities = 64/500 (12%), Positives = 151/500 (30%), Gaps = 73/500 (14%) Query: 43 RSPRPFNEIP-SPGDNGWLN-LYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVY 100 R R NE P G WL F ++ + +K+G I+ + + Sbjct: 12 RRTRRRNEPPLDKGMIPWLGHALEFGKDAA-----KFLTRMKEKHGDIFTVRAAGLYITV 66 Query: 101 VIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKK-SAAWKKDRVALNQEVM 159 ++D + + + +R ++L + +K R ++ + Sbjct: 67 LLDSNCYDAVLS------DVASLDQTSYAQVLMKRIFNMILPSHNPESEKKRAEMHFQGA 120 Query: 160 APEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQ 219 + N + + + + + G + + + F++ +FG Sbjct: 121 SLTQLSNSMQNNLRLLMTPSEMGLKTSEWKKDG-----LFNLCYSLLFKTGYLTVFGA-- 173 Query: 220 GMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADI 279 E + + + + + + ++ + W Sbjct: 174 ---ENNNSAALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASAAREKLWKWLTPSGLD-- 228 Query: 280 YTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFE-DIKANVTEMLA----GGVDTTSMT 334 + + G + L D + E +A + ++ G Sbjct: 229 -----------RKPREQSWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQGNAGP-----A 272 Query: 335 LQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTL 394 W + + + + +R E+ +H + P+ + + ETLRL + + Sbjct: 273 AFWVMGYLLTHPEALRAVREEIQGGKHLRLEERQK---NTPVFDSVLWETLRL-TAAALI 328 Query: 395 QRYLVNDLVL-----RDYMIPAKTLVQVAIY-ALGREPTFFFDPENFDPTRWLSKDKNIT 448 R + D + ++Y + + V + + +P PE F R+L+ D+ Sbjct: 329 TRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEK 388 Query: 449 Y----------FRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQ----HLSDVG 494 + ++ +G C GR A + + +L F VE+ + V Sbjct: 389 KDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVD 448 Query: 495 T-TFNL-ILMPEKPISFTFW 512 + IL P + + Sbjct: 449 PSRYGFGILQPAGDLEIRYR 468 >3AWQ-A nrPDB Length = 415 Score = 87.1 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 65/430 (15%), Positives = 126/430 (29%), Gaps = 62/430 (14%) Query: 83 QKYGP-IYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLL 141 Q+ G + + ++ + + + + + E + VA + GV Sbjct: 29 QRLGANAFESRFLLKKTNCLKGAKAAEIFYDTTRFEREGAMP---VAIQKTLFGQGGVQG 85 Query: 142 KKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDD 201 + R + +M PE + L +A R V + G + ++ + Sbjct: 86 LDGETHR-HRKQMFMGLMTPERVRALAQLFEAEWRRAVPG----WTRKGEIVFYDELHEP 140 Query: 202 LFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTK 261 L R + + EA + +F + P L+ + Sbjct: 141 LTRAVCAWAGVPL-----------PDDEAGNRAGELRALFDAAGSA--SPRHLWS----R 183 Query: 262 TWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVT 321 + V AW A + GS Y +R D +S Sbjct: 184 LARRRVDAW------AKRIIEGIRAGSIGSGSGTAAYAIAWHRDRHDDLLSPH------- 230 Query: 322 EMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAE-VLAARHQAQGDMATMLQLVPLLKAS 380 V+ L + R V + V A G A ++Q + Sbjct: 231 ---VAAVE---------LVNVLR-PTVAIAVYITFVAHALQTCSGIRAALVQQPDYAELF 277 Query: 381 IKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRW 440 ++E R +P + D P V + +Y + + DP+ F P R+ Sbjct: 278 VQEVRRFYPFFPAVVARASQDFEWEGMAFPEGRQVVLDLYGSNHDAATWADPQEFRPERF 337 Query: 441 LSKDKNITYFRNLGFGWGV----RQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTT 496 + + F + G G +C G I M + ++ R ++ D + Sbjct: 338 --RAWDEDSFNFIPQGGGDHYLGHRCPGEWIVLAIMKVAAHLLVNAMRYDV---PDQDLS 392 Query: 497 FNLILMPEKP 506 + +P P Sbjct: 393 IDFARLPALP 402 >3DBM-A nrPDB Length = 473 Score = 86.8 bits (213), Expect = 2e-17, Method: Composition-based stats. Identities = 75/486 (15%), Positives = 156/486 (32%), Gaps = 69/486 (14%) Query: 44 SPRPFNEIPSPGDNGWL-----NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKL----- 93 S +P EIP + L +F+ G + +Q +Q ++R + Sbjct: 4 SSKPLREIPGSYGIPFFQPIKDRLEYFYGTGGRDEYFRSRMQKYQS--TVFRANMPPGPF 61 Query: 94 --GNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQ--RPIGVLLKKSAAWKK 149 N + + ++D + +LF + ++ + R + L + Sbjct: 62 VSSNPKVIVLLDAKSFPILFDVSKVEKKDLFTGTYMPSTKLTGGYRVLSYLDPSEPRHAQ 121 Query: 150 DRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFES 209 + L M ++ +P + + L + K G ++ D+ + AF Sbjct: 122 LKNLLF--FMLKNSSNRVIPQFETTYTELFEGLEAELAKNGKAAFN-DVGEQA---AFRF 175 Query: 210 ITNVIFG---ERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDL--FRLFRTKTWK 264 + F E + + + + +P P L FRL Sbjct: 176 LGRAYFNSNPEETKLGTSAPTLISSWVLFNLAPTLDLGLPWFLQEPLLHTFRLPAFLIKS 235 Query: 265 DHVAAWDVIFSKADIY-TQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEM 323 + +D S A Q + + +VH+ + + G K+ F Sbjct: 236 TYNKLYDYFQSVATPVMEQAEKLGVPKDEAVHNILFAVCFNTFGGVKILF---------- 285 Query: 324 LAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATM--LQLVPLLKASI 381 TL+W NL Q L E+ A T+ ++ +PL K+ + Sbjct: 286 --------PNTLKWIGLA-GENLHTQ--LAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVV 334 Query: 382 KETLRLHPISVTLQRYLVNDLVLRDY----MIPAKTLVQVAIYALGREPTFFFDPENFDP 437 E+LR+ P ++ + + + ++ ++P F PE + P Sbjct: 335 YESLRIEPPVPPQYGKAKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVP 394 Query: 438 TRWLSKDKNITYFRNLGFGWGV---------RQCLGRRIAELEMTIFLINMLEN---FRV 485 R++ + + + + G +QC G+ L +F+I + F + Sbjct: 395 DRFVGDGEALLKYVW--WSNGPETESPTVENKQCAGKDFVVLITRLFVIELFRRYDSFEI 452 Query: 486 EIQHLS 491 E+ Sbjct: 453 ELGESP 458 >2YJN-B nrPDB Length = 381 Score = 70.6 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 26/156 (16%), Positives = 57/156 (36%), Gaps = 29/156 (18%) Query: 308 DSKMSFEDIKAN-----------VTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEV 356 D+++S + + L G + T+ T+ + ++ + + + + Sbjct: 193 DAQLSPQQLAVTEAAVAALPADPALRALFAGAEMTANTVVDAVLAVSAEPGLAERIADDP 252 Query: 357 LAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQ 416 AA+ ++ E LRLHP +R ++ L +++I V Sbjct: 253 AAAQR------------------TVAEVLRLHPALHLERRTATAEVRLGEHVIGEGEEVV 294 Query: 417 VAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRN 452 V + A R+P F +P+ D R + + + Sbjct: 295 VVVAAANRDPEVFAEPDRLDVDRPDADRALSAHRGH 330 >5XF8-3 nrPDB Length = 997 Score = 34.4 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 33/215 (15%), Positives = 63/215 (29%), Gaps = 27/215 (12%) Query: 291 KGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQD 350 K S D IL + L S + IK + ML GGV+ +NL+ Sbjct: 378 KLSKKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVE--------------KNLENGS 423 Query: 351 MLRAE--VLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYM 408 LR + +L + + ++ +I T R V L + D + Sbjct: 424 HLRGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGR-GSSGVGLTAAVTTDRETGERR 482 Query: 409 IPAKTLVQVAIYALGREP-TFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRI 467 + A +V + + D + + + G+ L Sbjct: 483 LEAGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAK------AGIHTTLN--- 533 Query: 468 AELEMTIFLINMLENFRVEIQHLSDVGTTFNLILM 502 A + + + V ++ +L+ Sbjct: 534 ARCSVIAAANPVFGQYDVNRDPHQNIALPDSLLSR 568 >4YXC-B nrPDB Length = 227 Score = 32.8 bits (73), Expect = 0.38, Method: Composition-based stats. Identities = 24/141 (17%), Positives = 47/141 (33%), Gaps = 22/141 (15%) Query: 281 TQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLY 340 N E + K + + G L L D+ ++ + TT+ + ++ Sbjct: 84 ILNSLNEEQPKNNPSDENTGALDDLWADA-LNEQKA-------------TTTKSAADAVF 129 Query: 341 EMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRL-HPISVTLQRYLV 399 + V ++ + + + +IKE LRL V L Sbjct: 130 QQLGGGDVSGAMQ-----DIDLIMDIPVKLTVELGRTRMTIKELLRLTQGSVVALDGLAG 184 Query: 400 N--DLVLRDYMIPAKTLVQVA 418 D+++ Y+I +V VA Sbjct: 185 EPLDILINGYLIAQGEVVVVA 205 >3RFT-A nrPDB Length = 267 Score = 31.3 bits (69), Expect = 0.94, Method: Composition-based stats. Identities = 8/54 (14%), Positives = 16/54 (29%), Gaps = 10/54 (18%) Query: 417 VAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAEL 470 + + ++ E P D +GV +C G +A + Sbjct: 106 IVFASSNHTIGYYPQTERLGPDVPARPDGL----------YGVSKCFGENLARM 149 >2B8N-A nrPDB Length = 429 Score = 31.3 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 10/73 (13%), Positives = 21/73 (28%), Gaps = 7/73 (9%) Query: 345 NLKVQDMLRAEVLAARHQAQGDMATMLQLVPLL--KASIKETLRLHPISVTLQRYLVNDL 402 + + L E++ +A + + +P L I L + R Sbjct: 15 DPESLKKLAIEIVKKSIEAVFPDRAVKETLPKLNLDRVI-----LVAVGKAAWRMAKAAY 69 Query: 403 VLRDYMIPAKTLV 415 + I +V Sbjct: 70 EVLGKKIRKGVVV 82 >3G6B-A nrPDB Length = 213 Score = 30.9 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 24/170 (14%), Positives = 50/170 (29%), Gaps = 10/170 (5%) Query: 216 GERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFS 275 G + E V + + + + + + N+ AA Sbjct: 52 GTNVDQIVERVKEASSQIGETLENIRSIEKLIQNIMRIARETNILALNATIEAARAGEAG 111 Query: 276 KADIYTQNFYWELR-QKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMT 334 K + N L + V +L S+ S E+++ +T T Sbjct: 112 KGFMIVANEVQNLSNETNEVTKQIVEKAREILESSQRSLENLEFMANLF-----ETVGKT 166 Query: 335 LQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKET 384 L M R ++ L EV + ++ ++ + ++ET Sbjct: 167 ----LQNMVRFMENIVKLLQEVRNSLDTSKESLSEKSAEIDSATKVLEET 212 >6F73-A nrPDB Length = 574 Score = 30.5 bits (67), Expect = 1.7, Method: Composition-based stats. Identities = 14/60 (23%), Positives = 29/60 (48%), Gaps = 6/60 (10%) Query: 41 STRSPRPFNEIPSPGDNGWLN----LYHFWRETGTHKVHLHHVQNFQKYGP--IYREKLG 94 + + +P + +PG + +LN LY W+E+ + ++ +KY P ++ K G Sbjct: 498 AAETLQPMMDAATPGGSVYLNEANHLYANWKESFYGDNYARLLRVKKKYDPDSVFYVKTG 557 >4YXB-D nrPDB Length = 80 Score = 30.5 bits (67), Expect = 2.1, Method: Composition-based stats. Identities = 14/50 (28%), Positives = 22/50 (44%), Gaps = 3/50 (6%) Query: 372 QLVPLLKASIKETLRL-HPISVTLQRYLVN--DLVLRDYMIPAKTLVQVA 418 + + +IKE LRL V L D+++ Y+I +V VA Sbjct: 9 DELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVVA 58 >1H4I-A nrPDB Length = 599 Score = 30.1 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 33/170 (19%), Positives = 58/170 (34%), Gaps = 13/170 (7%) Query: 42 TRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYV 101 T +P P+NE PGDN W + F R+ T + + + P V + + Sbjct: 259 TGNPAPWNETMRPGDNKW-TMTIFGRDADTGEAKFGYQKT-----PHDEWDYAGVNVMML 312 Query: 102 IDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAP 161 + +D + +P+R I + L +K + Q V P Sbjct: 313 SEQKDKDGKARKLLTHPDRNGIVYTLDRTDGALVSANKLDDTVNVFKSVDLKTGQPVRDP 372 Query: 162 EATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESIT 211 E + +D +++D + G+ S D +LF I Sbjct: 373 E----YGTRMDHLAKDICPSAMGYHNQ---GHDSYDPKRELFFMGINHIC 415 >1R6B-X nrPDB Length = 758 Score = 29.7 bits (65), Expect = 3.5, Method: Composition-based stats. Identities = 18/70 (25%), Positives = 31/70 (44%), Gaps = 2/70 (2%) Query: 333 MTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISV 392 MT++ L + N ++ L A + Q A + Q P+L AS +E R ++ Sbjct: 25 MTVEHLLLALLSNPSAREALEACSVDLVALRQELEAFIEQTTPVLPASEEE--RDTQPTL 82 Query: 393 TLQRYLVNDL 402 + QR L + Sbjct: 83 SFQRVLQRAV 92 >5NL1-A nrPDB Length = 156 Score = 29.4 bits (64), Expect = 4.1, Method: Composition-based stats. Identities = 17/97 (17%), Positives = 31/97 (31%), Gaps = 11/97 (11%) Query: 312 SFEDIKANVTEM---------LAGGV--DTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR 360 S +I + V + L G +T + + ++ NL + A Sbjct: 60 SKHEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALL 119 Query: 361 HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRY 397 G+ +LQ L ++ E LR + R Sbjct: 120 EDEGGNGRPLLQAAKGLAGAVSELLRSAQPASAEPRQ 156 >1SJ8-A nrPDB Length = 308 Score = 29.4 bits (64), Expect = 4.1, Method: Composition-based stats. Identities = 17/97 (17%), Positives = 31/97 (31%), Gaps = 11/97 (11%) Query: 312 SFEDIKANVTEM---------LAGGV--DTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR 360 S +I + V + L G +T + + ++ NL + A Sbjct: 58 SKHEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALL 117 Query: 361 HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRY 397 G+ +LQ L ++ E LR + R Sbjct: 118 EDEGGNGRPLLQAAKGLAGAVSELLRSAQPASAEPRQ 154 >1SJ7-A nrPDB Length = 174 Score = 29.4 bits (64), Expect = 4.1, Method: Composition-based stats. Identities = 17/97 (17%), Positives = 31/97 (31%), Gaps = 11/97 (11%) Query: 312 SFEDIKANVTEM---------LAGGV--DTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR 360 S +I + V + L G +T + + ++ NL + A Sbjct: 58 SKHEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALL 117 Query: 361 HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRY 397 G+ +LQ L ++ E LR + R Sbjct: 118 EDEGGNGRPLLQAAKGLAGAVSELLRSAQPASAEPRQ 154 >1V02-A nrPDB Length = 565 Score = 29.4 bits (64), Expect = 4.5, Method: Composition-based stats. Identities = 20/114 (17%), Positives = 40/114 (35%), Gaps = 12/114 (10%) Query: 38 AGISTRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYG--PIYREK--L 93 A T+ P N I P N W+N+Y +H + KYG P+Y + + Sbjct: 407 ASQETKGPDG-NAIGPPTGNAWINMYP-------KGLHDILMTMKNKYGNPPMYITENGM 458 Query: 94 GNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAW 147 G+++ + P + + + ++ + + L + W Sbjct: 459 GDIDKGDLPKPVALEDHTRLDYIQRHLSVLKQSIDLGADVRGYFAWSLLDNFEW 512 >4ZMU-A nrPDB Length = 345 Score = 28.6 bits (62), Expect = 6.3, Method: Composition-based stats. Identities = 9/33 (27%), Positives = 14/33 (42%), Gaps = 2/33 (6%) Query: 400 NDLVLRDYMIPAKTLVQVAIYALGREPTFFFDP 432 DL + I A + V + R+P F +P Sbjct: 76 RDLSFCGHAILASEPLMVTDAS--RDPRFHDNP 106 >6MDR-a nrPDB Length = 247 Score = 28.6 bits (62), Expect = 7.0, Method: Composition-based stats. Identities = 7/22 (31%), Positives = 8/22 (36%) Query: 330 TTSMTLQWHLYEMARNLKVQDM 351 T TL W + AR K Sbjct: 60 TLVTTLTWGVQCFARYPKHMKR 81 >2D0V-A nrPDB Length = 597 Score = 28.2 bits (61), Expect = 8.6, Method: Composition-based stats. Identities = 34/176 (19%), Positives = 58/176 (32%), Gaps = 29/176 (16%) Query: 44 SPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVID 103 +P P+NE PGDN W + R+ T K+ + + P V + + + Sbjct: 261 NPAPWNETMRPGDNKW-TMTITARDADTGKMKFGYQKT-----PHDEWDFAGVNVIMLSE 314 Query: 104 PEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEA 163 D + +P+R I + R G L+ D++ V Sbjct: 315 QTDKTGKKRKLLTHPDRNGIVYTLD------RENGDLIS------ADKLDDTVNVFKTVD 362 Query: 164 TKNFLPLLDAVSRDFVSVLHRR----IKKAG----SGNYSGDISDDLFRFAFESIT 211 K LP+ D ++ + + + A G+ S D LF I Sbjct: 363 LKTGLPVRDP---EYGTRMDHKGTDICPSAMGYHNQGHDSYDPQKQLFFMGINHIC 415 >2C4R-L nrPDB Length = 517 Score = 28.2 bits (61), Expect = 9.6, Method: Composition-based stats. Identities = 30/180 (16%), Positives = 56/180 (31%), Gaps = 26/180 (14%) Query: 242 HTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKG--------- 292 H +P+ + + F + DV+ ++ Q E KG Sbjct: 72 HGFLPLKEIAREYF--PANYSAHGRPNIKDVLREGQEVIVQIDKEERGNKGAALTTFISL 129 Query: 293 --------SVHHDYRGILYRLLGDSKMSFEDIKANV-----TEMLA--GGVDTTSMTLQW 337 + GI R+ GD + ++ A++ ++ GV ++ LQW Sbjct: 130 AGSYLVLMPNNPRAGGISRRIEGDDRTELKEALASLELPEGMGLIVRTAGVGKSAEALQW 189 Query: 338 HLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRY 397 L ++ + A Q + L+ I E L +P + L R Sbjct: 190 DLSFRLKHWEAIKKAAESRPAPFLIHQESNVIVRAFRDYLRQDIGEILIDNPKVLELARQ 249 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.306 0.125 0.329 Lambda K H 0.267 0.0386 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,843,781 Number of Sequences: 36641 Number of extensions: 767364 Number of successful extensions: 2832 Number of sequences better than 10.0: 186 Number of HSP's better than 10.0 without gapping: 279 Number of HSP's successfully gapped in prelim test: 61 Number of HSP's that attempted gapping in prelim test: 1997 Number of HSP's gapped (non-prelim): 367 length of query: 521 length of database: 10,336,785 effective HSP length: 101 effective length of query: 420 effective length of database: 6,636,044 effective search space: 2787138480 effective search space used: 2787138480 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 61 (28.2 bits)