BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P05093 (508 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5UYS-A nrPDB 1001 0.0 6B82-A nrPDB 487 e-138 4R1Z-A nrPDB 460 e-130 4R20-A nrPDB 406 e-113 3QZ1-A nrPDB 261 5e-70 6DWN-A nrPDB 248 4e-66 5VBU-A nrPDB 248 4e-66 2HI4-A nrPDB 236 2e-62 6IQ5-A nrPDB 214 9e-56 3DL9-A nrPDB 213 1e-55 4GQS-A nrPDB 198 4e-51 2PG7-A nrPDB 196 1e-50 3E6I-A nrPDB 194 7e-50 1N6B-A nrPDB 193 1e-49 5W0C-A nrPDB 190 1e-48 3TBG-A nrPDB 188 5e-48 5E58-A nrPDB 185 4e-47 2NNH-A nrPDB 185 5e-47 4H1N-A nrPDB 183 2e-46 3IBD-A nrPDB 182 2e-46 5E0E-A nrPDB 182 4e-46 5YLW-A nrPDB 170 2e-42 6DA2-A nrPDB 120 1e-27 5VEU-A nrPDB 115 7e-26 3K9V-A nrPDB 112 5e-25 4KPA-A nrPDB 104 9e-23 3MDV-A nrPDB 96 3e-20 6C94-A nrPDB 94 1e-19 3EL3-A nrPDB 86 3e-17 3JUS-A nrPDB 82 6e-16 3S79-A nrPDB 76 4e-14 6AYB-A nrPDB 74 2e-13 5JLC-A nrPDB 72 6e-13 3MZS-A nrPDB 70 3e-12 2VE3-A nrPDB 69 5e-12 4WMZ-A nrPDB 69 6e-12 2W0A-A nrPDB 64 1e-10 6M7X-A nrPDB 64 2e-10 2WX2-A nrPDB 64 2e-10 3N9Z-A nrPDB 63 4e-10 6CR2-A nrPDB 61 1e-09 2IJ7-A nrPDB 60 2e-09 2X2N-A nrPDB 60 2e-09 4ZGX-A nrPDB 59 5e-09 5FSA-A nrPDB 59 6e-09 6FYJ-A nrPDB 59 6e-09 3L4D-A nrPDB 58 9e-09 6A7J-A nrPDB 55 7e-08 3NC3-A nrPDB 55 8e-08 4YT3-A nrPDB 55 1e-07 1WIY-A nrPDB 54 2e-07 4RM4-A nrPDB 54 2e-07 3TYW-A nrPDB 54 2e-07 6A7I-A nrPDB 54 2e-07 5L1U-A nrPDB 52 5e-07 5M0P-A nrPDB 52 5e-07 3R9C-A nrPDB 52 6e-07 5L94-A nrPDB 52 8e-07 6B11-A nrPDB 50 2e-06 5XNT-A nrPDB 50 2e-06 5LIE-A nrPDB 50 2e-06 5IT1-A nrPDB 50 3e-06 6F0B-A nrPDB 49 5e-06 3SN5-A nrPDB 49 5e-06 2X9P-A nrPDB 48 1e-05 2Z36-A nrPDB 48 1e-05 3P3Z-A nrPDB 47 1e-05 1GWI-A nrPDB 47 2e-05 5Y1I-A nrPDB 47 2e-05 3WVS-A nrPDB 47 2e-05 1F4U-A nrPDB 47 2e-05 2ZQJ-A nrPDB 47 2e-05 3AWQ-A nrPDB 47 3e-05 3TKT-A nrPDB 47 3e-05 2Y5N-A nrPDB 46 4e-05 2RFC-A nrPDB 46 4e-05 5FOI-A nrPDB 45 7e-05 2WIY-A nrPDB 45 7e-05 5OFQ-A nrPDB 45 8e-05 4GGV-A nrPDB 45 1e-04 3ABA-A nrPDB 44 1e-04 3MGX-A nrPDB 44 2e-04 2XKR-A nrPDB 44 2e-04 4MM0-A nrPDB 44 2e-04 5HIW-A nrPDB 43 3e-04 4TRI-A nrPDB 43 3e-04 3EJB-B nrPDB 43 3e-04 4WPZ-A nrPDB 43 3e-04 5FYF-A nrPDB 43 4e-04 1Q5D-A nrPDB 43 4e-04 1EHE-A nrPDB 43 4e-04 1ODO-A nrPDB 42 5e-04 6M7L-A nrPDB 42 5e-04 4YZR-A nrPDB 42 7e-04 2VZM-A nrPDB 42 8e-04 3RWL-A nrPDB 42 8e-04 1UE8-A nrPDB 42 9e-04 5XW2-A nrPDB 42 0.001 2WIO-A nrPDB 41 0.001 3ABB-A nrPDB 41 0.001 3BUJ-A nrPDB 41 0.001 6GMF-A nrPDB 41 0.001 5XJN-A nrPDB 41 0.001 5GWE-A nrPDB 41 0.001 2ZBZ-A nrPDB 40 0.002 6G71-A nrPDB 40 0.003 5YSW-A nrPDB 40 0.003 3B98-A nrPDB 40 0.003 4Z5Q-A nrPDB 40 0.003 5NWS-A nrPDB 40 0.003 5YHJ-A nrPDB 39 0.004 4XE3-A nrPDB 39 0.004 1UED-A nrPDB 39 0.004 5VWS-A nrPDB 39 0.006 4JBT-A nrPDB 39 0.006 5HDI-A nrPDB 39 0.007 4Z5P-A nrPDB 38 0.011 5CJE-A nrPDB 38 0.012 5EX6-C nrPDB 37 0.014 5LIV-A nrPDB 37 0.015 6HQG-A nrPDB 37 0.015 5DE9-A nrPDB 37 0.016 6G5O-A nrPDB 37 0.017 4OQR-A nrPDB 37 0.020 3WEC-A nrPDB 37 0.020 4OQS-A nrPDB 37 0.023 6GK6-A nrPDB 37 0.023 1Z8P-A nrPDB 37 0.025 6F88-A nrPDB 37 0.026 2FR7-A nrPDB 37 0.029 4UBS-A nrPDB 36 0.037 4PWV-A nrPDB 35 0.100 1CPT-A nrPDB 34 0.12 4DO1-A nrPDB 34 0.13 2IAG-A nrPDB 33 0.41 3NV6-A nrPDB 32 0.44 6CA8-A nrPDB 32 0.52 5Z9I-A nrPDB 32 0.61 5DQN-A nrPDB 32 0.61 2QBO-A nrPDB 32 0.62 5OWV-A nrPDB 32 0.75 3A50-A nrPDB 32 0.94 1LG9-A nrPDB 31 1.0 4BDV-A nrPDB 31 1.4 3ZHP-A nrPDB 30 1.9 6HQW-A nrPDB 30 2.4 6HQD-A nrPDB 30 2.6 5OMS-A nrPDB 30 3.3 3CDK-A nrPDB 30 3.4 4BN9-A nrPDB 30 3.6 2NZA-A nrPDB 29 3.8 3A1L-A nrPDB 29 4.1 3OFT-A nrPDB 29 4.2 6CVC-A nrPDB 29 4.3 3IVY-A nrPDB 29 4.9 4ONJ-A nrPDB 28 7.7 5KYO-A nrPDB 28 8.0 3A52-A nrPDB 28 8.1 1ZBU-A nrPDB 28 8.8 >5UYS-A nrPDB Length = 494 Score = 1001 bits (2589), Expect = 0.0, Method: Compositional matrix adjust. Identities = 485/485 (100%), Positives = 485/485 (100%) Query: 24 GAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAK 83 GAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAK Sbjct: 6 GAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAK 65 Query: 84 EVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLE 143 EVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLE Sbjct: 66 EVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLE 125 Query: 144 KIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNE 203 KIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNE Sbjct: 126 KIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNE 185 Query: 204 GIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNML 263 GIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNML Sbjct: 186 GIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNML 245 Query: 264 DTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQ 323 DTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQ Sbjct: 246 DTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQ 305 Query: 324 VKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGE 383 VKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGE Sbjct: 306 VKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGE 365 Query: 384 FAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCI 443 FAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCI Sbjct: 366 FAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCI 425 Query: 444 GEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 503 GEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ Sbjct: 426 GEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 485 Query: 504 AEGST 508 AEGST Sbjct: 486 AEGST 490 >6B82-A nrPDB Length = 509 Score = 487 bits (1253), Expect = e-138, Method: Compositional matrix adjust. Identities = 234/479 (48%), Positives = 325/479 (67%), Gaps = 2/479 (0%) Query: 24 GAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAK 83 G + P SL SLP++GSL L H F LQKKYG +YS+ MG+ +IV +H AK Sbjct: 21 GNRSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHHHAK 80 Query: 84 EVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLE 143 E+LIKKGK F+GRP+ T D+ + + K IAFAD + W+ HR++ +F +G +E Sbjct: 81 EILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGEGSVSIE 140 Query: 144 KIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNE 203 KIIC+E S++C++L ++D+ + AVTNV+ +CFN+SYK GD E + Y++ Sbjct: 141 KIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSSYKRGDAEFESMLQYSQ 200 Query: 204 GIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNML 263 GI+D ++KDSLVD+ PWL+IFPNK L L+ + IR+ LL K E +K + + ++L Sbjct: 201 GIVDTVAKDSLVDIFPWLQIFPNKDLRILRQCISIRDKLLQKKYEEHKVTYSDNVQRDLL 260 Query: 264 DTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQ 323 D L++AK +S+N N+ L+++H+L T+G+IFGAGVETTT+ +KW++A+L+HNPQ Sbjct: 261 DALLRAKRSSENNNSSTRDVG--LTEDHVLMTVGEIFGAGVETTTTTLKWSIAYLVHNPQ 318 Query: 324 VKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGE 383 V++K+ EE+D +G R P +SDR L LEATI EV+R+RPV+P+LIPH A DSS+GE Sbjct: 319 VQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIPHVALQDSSVGE 378 Query: 384 FAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCI 443 + V KGT V+IN+W+LHH+EKEW P+ F P RFLN G L PS SYLPFGAG R C+ Sbjct: 379 YTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCL 438 Query: 444 GEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREA 502 GE LA+ ELFL +AW+LQRF LE+P LP L+G VV FKV KVR W ++ Sbjct: 439 GEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKKFKVVAKVRADWEKS 497 >4R1Z-A nrPDB Length = 439 Score = 460 bits (1184), Expect = e-130, Method: Compositional matrix adjust. Identities = 217/435 (49%), Positives = 301/435 (69%), Gaps = 2/435 (0%) Query: 68 MGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRL 127 MG+ +IV +H AKE+LIKKGK F+GRP+ T D+ + + K IAFAD + W+ HR++ Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKM 60 Query: 128 AMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTS 187 +F +G +EKIIC+E S++C++L ++D+ + AVTNV+ +CFN+S Sbjct: 61 VHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSS 120 Query: 188 YKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKIL 247 YK GD E + Y++GI+D ++KDSLVD+ PWL+IFPNK L L+ + IR+ LL K Sbjct: 121 YKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLTILRQCISIRDKLLQKKY 180 Query: 248 ENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETT 307 E +K + + ++LD L++AK +S+N N+ L+++H+L T+GDIFGAGVETT Sbjct: 181 EEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVG--LTEDHVLMTVGDIFGAGVETT 238 Query: 308 TSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVA 367 T+V+KW++A+L+HNPQV++K+ EE+D +G R P +SDR L LEATIREVLR+RPV+ Sbjct: 239 TTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPVS 298 Query: 368 PMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLIS 427 P+LIPH A DSS+GE+ V KGT V+INLW+LHH++KEW P+ F P RFLN G L Sbjct: 299 PLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEGDGLCC 358 Query: 428 PSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLID 487 PS SYLPFGAG R C+GE LA+ ELFL +AW+LQRF LE+P LP L+G VV Sbjct: 359 PSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPK 418 Query: 488 SFKVKIKVRQAWREA 502 FKV KVR W ++ Sbjct: 419 KFKVVAKVRADWEKS 433 >4R20-A nrPDB Length = 486 Score = 406 bits (1044), Expect = e-113, Method: Compositional matrix adjust. Identities = 195/447 (43%), Positives = 290/447 (64%), Gaps = 9/447 (2%) Query: 50 HNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNR 109 H F +L +YGP++ + G T++V L +EVL+++G++F+GRP+M T D+ + Sbjct: 42 HLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQGG 101 Query: 110 KGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISF 169 K IAFAD W+ HRRL ++F LF +G KL+ I+ + +LC+ L GQS D+S Sbjct: 102 KDIAFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSDLSV 161 Query: 170 PVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTL 229 + AVTNVI + F++SY+ DPEL + YN+GI+ +++ LVD+ PWL+IFPNK L Sbjct: 162 VLMRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIFPWLRIFPNKDL 221 Query: 230 EKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSD 289 ++LK V IR+ LL K L +K+ ++LD L+ + G+ G D +++ Sbjct: 222 KRLKECVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALL---IGQQRGSGGADD----ITE 274 Query: 290 NHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNR 349 +H+L T + FGAGVETT++ + WT+AFLLH+PQ+++++ E+D+ VG R P +SDR Sbjct: 275 DHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPH 334 Query: 350 LLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQP 409 L LL+A + EV+R+RPV+P+LIPH A D+S+G +V KGT V++N+WA+HH+ K W QP Sbjct: 335 LPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQP 394 Query: 410 DQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPD 469 +QF PERFL P+G + S+LPFGAGPR C+GE LAR ELFL ++ LQRF P Sbjct: 395 EQFNPERFLEPSGKK--KTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFSCPS 452 Query: 470 DGQLPSLEGIPKVVFLIDSFKVKIKVR 496 + LP L+G VV + + V + R Sbjct: 453 EASLPDLQGRFGVVLQPERYTVTVTPR 479 >3QZ1-A nrPDB Length = 496 Score = 261 bits (667), Expect = 5e-70, Method: Compositional matrix adjust. Identities = 159/480 (33%), Positives = 250/480 (52%), Gaps = 41/480 (8%) Query: 41 PFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMA 100 P LP H L +K GP+Y +R+G + V++ + +E +I+K DF+GRPQ+ Sbjct: 43 PNLPIH------LLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAGRPQIP 96 Query: 101 TLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATH 160 + + S + I+ D W+ H++L + AL +E + Q C+ + Sbjct: 97 SYKLVSQRCQDISLGDYSLLWKAHKKLTRS--ALLLGTRSSMEPWVDQLTQEFCERMRVQ 154 Query: 161 NGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLS-----KDSLV 215 G + I + ++I + F G+ E ++ +++ + D + ++ Sbjct: 155 AGAPVTIQKEFSLLTCSIICYLTF------GNKEDTLVHAFHDCVQDLMKTWDHWSIQIL 208 Query: 216 DLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDN 275 D+VP+L+ FPN L +LK ++ R+ ++ K L +KE + +M D ++Q + Sbjct: 209 DMVPFLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDYMLQG-VGRQR 267 Query: 276 GNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQN 335 GP Q L + H+ ++ D+F G ETT S + W +AFLLH+P+++++L EE+D+ Sbjct: 268 VEEGPGQ----LLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELDRE 323 Query: 336 VG----FSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTE 391 +G SR T DR RL LL ATI EVLRLRPV P+ +PH+ SSI + + +G Sbjct: 324 LGPGASCSRV-TYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMV 382 Query: 392 VIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQE 451 VI NL H +E W QP +F P+RFL P S L FG G R C+GE LAR E Sbjct: 383 VIPNLQGAHLDETVWEQPHEFRPDRFLEPGANP------SALAFGCGARVCLGESLARLE 436 Query: 452 LFLIMAWLLQRFDLEVPDDGQLPSLEGIP--KVVFLIDSFKVKIKVR----QAWREAQAE 505 LF+++A LLQ F L P G LPSL+ P V + F+V+++ R AW A A+ Sbjct: 437 LFVVLARLLQAFTLLPPPVGALPSLQPDPYCGVNLKVQPFQVRLQPRGVEAGAWESASAQ 496 >6DWN-A nrPDB Length = 491 Score = 248 bits (634), Expect = 4e-66, Method: Compositional matrix adjust. Identities = 153/464 (32%), Positives = 241/464 (51%), Gaps = 25/464 (5%) Query: 19 KRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGH 78 K G K P PL+G + L ++ H+ ++ ++YG + +R+G+ V++ Sbjct: 4 KTSSKGLKNPPGPWGWPLIGHMLTLGKNPHL--ALSRMSQQYGDVLQIRIGSTPVVVLSG 61 Query: 79 HQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLA---MATFALF 135 ++ L+++G DF GRP + T + SN + DSG W RRLA + +F++ Sbjct: 62 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 121 Query: 136 KDGDQK----LEKIICQE----ISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTS 187 D LE+ + +E ISTL +++A G + V V+VTNVI ICF Sbjct: 122 SDPASSTSCYLEEHVSKEAEVLISTLQELMAG-PGHFNPYRY-VVVSVTNVICAICFGRR 179 Query: 188 YKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKIL 247 Y + EL + N N + + + D +P L+ PN +L K + + K++ Sbjct: 180 YDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMV 239 Query: 248 ENYKEKFRSDSITNMLDTLM---QAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGV 304 + + + F I ++ D+L+ Q K +N N LSD I+ + D+FGAG Sbjct: 240 KEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQ-------LSDEKIINIVLDLFGAGF 292 Query: 305 ETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLR 364 +T T+ + W+L +L+ NP+V++K+ EE+D +G SR P +SDR+ L +EA I E R Sbjct: 293 DTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHS 352 Query: 365 PVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQ 424 P IPH D+S+ F + KG V +N W ++H++K W P +F+PERFL P G Sbjct: 353 SFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAI 412 Query: 425 LISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468 S + FG G R CIGE +AR E+FL +A LLQR + VP Sbjct: 413 DKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 456 >5VBU-A nrPDB Length = 476 Score = 248 bits (634), Expect = 4e-66, Method: Compositional matrix adjust. Identities = 147/457 (32%), Positives = 239/457 (52%), Gaps = 34/457 (7%) Query: 53 FFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGI 112 L +K+GPIY + +G + V++ + +E ++KK DF+GRP+ T + S N + Sbjct: 30 LLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL 89 Query: 113 AFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVF 172 + D W+ H++L + AL +E ++ Q C+ + G + I Sbjct: 90 SLGDYSLLWKAHKKLTRS--ALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFS 147 Query: 173 VAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDS-----LVDLVPWLKIFPNK 227 + ++I + F K+ N++ Y + I + L S +VD++P+L+ FPN Sbjct: 148 LLTCSIICYLTFGDKIKDD----NLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNP 203 Query: 228 TLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGP--DQDSE 285 L +LK ++ R+ ++ L +KE + +M+D ++Q G A P ++ S Sbjct: 204 GLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQ-------GVAQPSMEEGSG 256 Query: 286 LLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVG----FSRT 341 L + H+ D+ G ETT + + W + FLLH+P+++++L EE+D +G SR Sbjct: 257 QLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRV 316 Query: 342 PTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHH 401 P DR RL LL ATI EVLRLRPV P+ +PH+ SSI + + +GT +I NL H Sbjct: 317 P-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHL 375 Query: 402 NEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQ 461 +E W +P +F P+RFL P L FG G R C+GE LAR ELF+++ LLQ Sbjct: 376 DETVWERPHEFWPDRFLEPGKNS------RALAFGCGARVCLGEPLARLELFVVLTRLLQ 429 Query: 462 RFDLEVPDDGQLPSLEGIP--KVVFLIDSFKVKIKVR 496 F L +P LPSL+ +P V+ + F+V+++ R Sbjct: 430 AFTL-LPSGDALPSLQPLPHCSVILKMQPFQVRLQPR 465 >2HI4-A nrPDB Length = 495 Score = 236 bits (602), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 140/462 (30%), Positives = 241/462 (52%), Gaps = 25/462 (5%) Query: 21 RCP-GAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHH 79 R P G K P PL+G + L ++ H+ ++ ++YG + +R+G+ +++ Sbjct: 10 RVPKGLKSPPEPWGWPLLGHVLTLGKNPHL--ALSRMSQRYGDVLQIRIGSTPVLVLSRL 67 Query: 80 QLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLA---MATFALFK 136 ++ L+++G DF GRP + T + ++ + DSG W RRLA + TF++ Sbjct: 68 DTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIAS 127 Query: 137 DGDQK----LEKIICQE----ISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSY 188 D LE+ + +E IS L +++A D V V+V NVI +CF + Sbjct: 128 DPASSSSCYLEEHVSKEAKALISRLQELMA--GPGHFDPYNQVVVSVANVIGAMCFGQHF 185 Query: 189 -KNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKIL 247 ++ D L++++N +E ++ S + +D P L+ PN L++ K+ + L K + Sbjct: 186 PESSDEMLSLVKNTHE-FVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTV 244 Query: 248 ENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETT 307 + + + F +S+ ++ L + + GP L+ I+ + DIFGAG +T Sbjct: 245 QEHYQDFDKNSVRDITGALFK------HSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 298 Query: 308 TSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVA 367 T+ + W+L +L+ P++++K+ +E+D +G R P +SDR +L LEA I E R Sbjct: 299 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 358 Query: 368 PMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLIS 427 P IPH D+++ F + K V +N W ++H+ + W P +F PERFL GT + Sbjct: 359 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 418 Query: 428 P-SVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468 P S + FG G R CIGE+LA+ E+FL +A LLQ+ + VP Sbjct: 419 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVP 460 >6IQ5-A nrPDB Length = 463 Score = 214 bits (544), Expect = 9e-56, Method: Compositional matrix adjust. Identities = 129/462 (27%), Positives = 225/462 (48%), Gaps = 20/462 (4%) Query: 50 HNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNR 109 H +F +L ++YG ++ +R+G+ V++ + + L+++G F+ RP A+ + S R Sbjct: 4 HLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGR 63 Query: 110 KGIAFADSGAHWQLHRRLAMATFALF----KDGDQKLEKIICQEISTLCDML--ATHNGQ 163 +AF HW++ RR A + F Q LE + E L +L + +G Sbjct: 64 S-MAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGA 122 Query: 164 SIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKI 223 +D VAV NV+S +CF Y + DPE + ++NE + SLVD++PWL+ Sbjct: 123 FLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQY 182 Query: 224 FPNKTLEKLKSHVKIRNDLLNKILENY---KEKFRSDSI-TNMLDTLM---QAKMNSDNG 276 FPN + ++ + N IL+ + E R + +M+D + + K D+ Sbjct: 183 FPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSH 242 Query: 277 NAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV 336 G D E ++ TI DIFGA +T ++ ++W L P V+ ++ E+DQ V Sbjct: 243 GGGARLDLE-----NVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVV 297 Query: 337 GFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINL 396 G R P + D+ L + A + E +R P+ IPH ++S+ + + K T V +N Sbjct: 298 GRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQ 357 Query: 397 WALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIM 456 W+++H+ +W P+ F P RFL+ G + + F G R CIGE L++ +LFL + Sbjct: 358 WSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFI 417 Query: 457 AWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQA 498 + L + D + + + + SFKV + +R++ Sbjct: 418 SILAHQCDFRA-NPNEPAKMNFSYGLTIKPKSFKVNVTLRES 458 >3DL9-A nrPDB Length = 479 Score = 213 bits (543), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 122/418 (29%), Positives = 221/418 (52%), Gaps = 11/418 (2%) Query: 55 KLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAF 114 K + YG I+S+ +G +TV++ + + KE L+ + + F+ RP + L + G+ Sbjct: 42 KQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLP-LFMKMTKMGGLLN 100 Query: 115 ADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVA 174 + G W HRRLA+ +F F G + E I +E D + T+ G+ D + A Sbjct: 101 SRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNA 160 Query: 175 VTNVISLICFNTSYKNGDPEL-NVIQNYNEGI-IDNLSKDSLVDLVPWLKIFPNKTLEKL 232 V+N+ +LI F + D + ++I+ ++E + + + L + PW+ I P ++L Sbjct: 161 VSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQL 220 Query: 233 KSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292 + + D L++++E + + +D + D + G + S S ++ Sbjct: 221 FRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYL------DEMDQGKNDPSSTFSKENL 274 Query: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352 + ++G++ AG ETTT+V++W + F+ P ++ ++ +EID +G + P+ D+ ++ Sbjct: 275 IFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPY 334 Query: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412 EA + EVLR + P+ I H + D+ + +++ KGT VI NL+++H +EK W P+ F Sbjct: 335 TEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVF 394 Query: 413 MPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDD 470 PERFL+ +G + + +PF G R C+GE LAR E+FL LLQRF L P + Sbjct: 395 HPERFLDSSG--YFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHE 450 >4GQS-A nrPDB Length = 477 Score = 198 bits (504), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 130/422 (30%), Positives = 218/422 (51%), Gaps = 30/422 (7%) Query: 56 LQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFA 115 L K YGP++++ G + V++ +++ KE LI G++FSGR + A N GI F+ Sbjct: 40 LSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERA-NRGFGIVFS 98 Query: 116 DSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAV 175 + G W+ RR ++ T F G + +E + +E L + L D +F + A Sbjct: 99 N-GKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAP 157 Query: 176 TNVISLICFNTSYKNGDPE-LNVIQNYNEGIIDNLSKDSLVDLVPWLKI----------F 224 NVI I F + D + LN+++ NE I + PW++I F Sbjct: 158 CNVICSIIFQKRFDYKDQQFLNLMEKLNENI--------RIVSTPWIQICNNFPTIIDYF 209 Query: 225 PNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDS 284 P + LK+ + +D+L K+ E ++E ++ + +D + KM + N Q S Sbjct: 210 PGTHNKLLKNLAFMESDILEKVKE-HQESMDINNPRDFIDCFL-IKMEKEKQN----QQS 263 Query: 285 ELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTI 344 E +N ++T D+ GAG ETT++ +++ L LL +P+V K+ EEI++ VG +R+P + Sbjct: 264 EFTIENLVITA-ADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCM 322 Query: 345 SDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEK 404 DR + +A + EV R + P +PH D + + KGT ++ +L ++ H+ K Sbjct: 323 QDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNK 382 Query: 405 EWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFD 464 E+ P+ F P FL+ G S ++PF AG R C+GE LAR ELFL + ++LQ F+ Sbjct: 383 EFPNPEMFDPRHFLDEGGN--FKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFN 440 Query: 465 LE 466 L+ Sbjct: 441 LK 442 >2PG7-A nrPDB Length = 476 Score = 196 bits (499), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 129/451 (28%), Positives = 226/451 (50%), Gaps = 15/451 (3%) Query: 19 KRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGH 78 K+ K P LP +G+ L M+N+ K+ ++YGP++++ +G + V++ Sbjct: 3 KKTSSKGKLPPGPTPLPFIGNYLQLNTE-QMYNSLMKISERYGPVFTIHLGPRRVVVLCG 61 Query: 79 HQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDG 138 H +E L+ + ++FSGR + AT D G+ F++ QL RR ++AT F G Sbjct: 62 HDAVREALVDQAEEFSGRGEQATFDWVFKG-YGVVFSNGERAKQL-RRFSIATLRDFGVG 119 Query: 139 DQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVI 198 + +E+ I +E L D L G +ID +F + V+NVIS I F + D E + Sbjct: 120 KRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSL 179 Query: 199 QNYNEGIID--NLSKDSLVDLVPW-LKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255 GI + S L ++ +K P + + ++ D + K +E+ + Sbjct: 180 LRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQL-LQGLEDFIAKKVEHNQRTLD 238 Query: 256 SDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTL 315 +S + +D+ + +M + N ++E N ++TT+ +F G ET ++ +++ Sbjct: 239 PNSPRDFIDSFL-IRMQEEEKNP----NTEFYLKNLVMTTL-QLFVGGTETVSTTLRYGF 292 Query: 316 AFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKA 375 L+ +P+V+ K++EEID+ +G +R P DR ++ +EA I E+ R V PM + + Sbjct: 293 LLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRV 352 Query: 376 NVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPF 435 D+ +F + KGTEV L ++ + + P F P+ FLN G S +++PF Sbjct: 353 KKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQ--FKKSDAFVPF 410 Query: 436 GAGPRSCIGEILARQELFLIMAWLLQRFDLE 466 G R+C GE LAR ELFL ++Q F L+ Sbjct: 411 SIGKRNCFGEGLARMELFLFFTTVMQNFRLK 441 >3E6I-A nrPDB Length = 476 Score = 194 bits (493), Expect = 7e-50, Method: Compositional matrix adjust. Identities = 137/458 (29%), Positives = 240/458 (52%), Gaps = 30/458 (6%) Query: 19 KRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGH 78 K+ K P LP++G+L F ++ +F +L +++GP++++ +G++ V++ Sbjct: 3 KKTSSKGKLPPGPFPLPIIGNL-FQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHG 61 Query: 79 HQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDG 138 ++ KE L+ +FSGR + ++ +GI F ++G W+ RR ++ T + G Sbjct: 62 YKAVKEALLDYKDEFSGRGDLPAFH--AHRDRGIIF-NNGPTWKDIRRFSLTTLRNYGMG 118 Query: 139 DQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE-LNV 197 Q E I +E L + L GQ D +F + A NVI+ I F + D + L + Sbjct: 119 KQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL 178 Query: 198 IQNYNEGIIDNLSKDSLVDLVPWLKIFPN--KTLEKLK-SHVK-IRN--DLLNKILENYK 251 + +NE L+ PWL+++ N L L SH K I+N ++ + E K Sbjct: 179 MYLFNENF-------HLLS-TPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVK 230 Query: 252 EKFRS---DSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTT 308 E +S + ++ D L+ +M + +A L + + I T+ D+F AG ETT+ Sbjct: 231 EHHQSLDPNCPRDLTDCLL-VEMEKEKHSA-----ERLYTMDGITVTVADLFFAGTETTS 284 Query: 309 SVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAP 368 + +++ L L+ P++++KL+EEID+ +G SR P I DR + ++A + E+ R + P Sbjct: 285 TTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVP 344 Query: 369 MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISP 428 +PH+A D+ + + KGT V+ L ++ ++ +E+ P++F PE FLN G Sbjct: 345 SNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK--FKY 402 Query: 429 SVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466 S + PF G R C GE LAR ELFL++ +LQ F+L+ Sbjct: 403 SDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 440 >1N6B-A nrPDB Length = 473 Score = 193 bits (491), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 135/465 (29%), Positives = 233/465 (50%), Gaps = 46/465 (9%) Query: 19 KRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGH 78 K+ K P P++G++ + + + K + YGP+++V +G K TV++ Sbjct: 3 KKTSSKGKLPPGPTPFPIIGNILQIDAKD-ISKSLTKFSECYGPVFTVYLGMKPTVVLHG 61 Query: 79 HQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDG 138 ++ KE L+ G++F+GR + L+ S GIAF+++ W+ RR ++ T F G Sbjct: 62 YEAVKEALVDLGEEFAGRGSVPILEKVSKGL-GIAFSNAKT-WKEMRRFSLMTLRNFGMG 119 Query: 139 DQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE-LNV 197 + +E I +E L + L N D +F + A NVI + F+ + D E L + Sbjct: 120 KRSIEDRIQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKL 179 Query: 198 IQNYNEGIIDNLSKDSLVDLV--PWLKIFPN------------KTLEKLKSHVKIRNDLL 243 +++ +E V+L+ PWL+++ N KTL K ++K Sbjct: 180 MESLHEN----------VELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIK------ 223 Query: 244 NKILENYKEKFRSDSITNMLDTL--MQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFG 301 N I+E KE + + N D + KM +N + ++ + D+FG Sbjct: 224 NFIMEKVKEHQKLLDVNNPRDFIDCFLIKMEQENNLE--------FTLESLVIAVSDLFG 275 Query: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361 AG ETT++ ++++L LL +P+V ++ EEI++ +G R+P + DR+R+ +A I E+ Sbjct: 276 AGTETTSTTLRYSLLLLLKHPEVAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQ 335 Query: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA 421 R + P +PH D + + KGT++I +L ++ H+EK + P F P FL+ + Sbjct: 336 RFIDLLPTNLPHAVTRDVRFRNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDES 395 Query: 422 GTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466 G S ++PF AG R C+GE LAR ELFL + +LQ F L+ Sbjct: 396 GN--FKKSDYFMPFSAGKRMCVGEGLARMELFLFLTSILQNFKLQ 438 >5W0C-A nrPDB Length = 477 Score = 190 bits (483), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 127/414 (30%), Positives = 218/414 (52%), Gaps = 14/414 (3%) Query: 56 LQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFA 115 L K YGP++++ G K V++ ++ KE LI G++FSGR + L +N GI F+ Sbjct: 40 LSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGR-GIFPLAERANRGFGIVFS 98 Query: 116 DSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAV 175 + G W+ RR ++ T F G + +E + +E L + L D +F + A Sbjct: 99 N-GKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAP 157 Query: 176 TNVISLICFNTSYKNGDPE-LNVIQNYNEGI--IDNLSKDSLVDLVPWLKIFPNKTLEKL 232 NVI I F+ + D + LN+++ NE I + + + P + FP + L Sbjct: 158 CNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLL 217 Query: 233 KSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292 K+ +++ +L K+ E ++E ++ + +D + KM + N Q SE ++ + Sbjct: 218 KNVAFMKSYILEKVKE-HQESMDMNNPQDFIDCFLM-KMEKEKHN----QPSEFTIES-L 270 Query: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352 T D+FGAG ETT++ +++ L LL +P+V K+ EEI++ +G +R+P + DR+ + Sbjct: 271 ENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPY 330 Query: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412 +A + EV R + P +PH D + + KGT ++I+L ++ H+ KE+ P+ F Sbjct: 331 TDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMF 390 Query: 413 MPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466 P FL+ G S ++PF AG R C+GE LA ELFL + +LQ F+L+ Sbjct: 391 DPHHFLDEGGN--FKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLK 442 >3TBG-A nrPDB Length = 479 Score = 188 bits (477), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 119/431 (27%), Positives = 213/431 (49%), Gaps = 12/431 (2%) Query: 53 FFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS--NNRK 110 F +L++++G ++S+++ V++ +E L+ G+D + RP + I + Sbjct: 36 FDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQ 95 Query: 111 GIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFP 170 G+ A G W+ RR +++T G + LE+ + +E + LC A H+G+ + Sbjct: 96 GVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGL 155 Query: 171 VFVAVTNVISLICFNTSYKNGDPE-LNVIQNYNEGIIDNLS-KDSLVDLVPWLKIFPNKT 228 + AV+NVI+ + ++ DP L ++ EG+ + +++ VP L P Sbjct: 156 LDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALA 215 Query: 229 LEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLS 288 + L+ L +++L ++ + L A+M GN P+ + Sbjct: 216 GKVLRFQKAFLTQL-DELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGN--PESS---FN 269 Query: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348 D ++ + D+F AG+ TT++ + W L ++ +P V++++ +EID +G R P + D+ Sbjct: 270 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 329 Query: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408 + A I EV R + P+ + H + D + F + KGT +I NL ++ +E W + Sbjct: 330 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 389 Query: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468 P +F PE FL+ G + P ++LPF AG R+C+GE LAR ELFL LLQ F VP Sbjct: 390 PFRFHPEHFLDAQG-HFVKPE-AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVP 447 Query: 469 DDGQLPSLEGI 479 PS G+ Sbjct: 448 TGQPRPSHHGV 458 >5E58-A nrPDB Length = 493 Score = 185 bits (470), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 124/443 (27%), Positives = 221/443 (49%), Gaps = 18/443 (4%) Query: 47 GHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS 106 G N+F ++++KYG +++V +G + V++ + +E L+ + + FSGR +A + Sbjct: 49 GGFLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTIAVIKPVI 108 Query: 107 NNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSID 166 + G+ F++ G W++ RR ++AT F G + +E I +E L + L G +D Sbjct: 109 GD-YGMIFSN-GERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVEELQKSQGAPLD 166 Query: 167 ISFPVFVAVTNVISLICFNTSYKNGDPE-LNVIQNYNE--GIIDNLSKDSLVDLVPWLKI 223 +F N+I I F Y D + L ++ + ++ + S ++K Sbjct: 167 PTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFSGFMKY 226 Query: 224 FPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQD 283 FP + ++ +I D + + +E ++ + + +DT + +M + N Q Sbjct: 227 FPGAHRQITRNLQEIL-DYVGQSVEKHRATLDPSNPRDFIDTYL-LRMEKEKSN----QH 280 Query: 284 SELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPT 343 +E N +L ++ +F AG ETT++ +++ +L P V +K+ +EIDQ +G R PT Sbjct: 281 TEFHHQN-LLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPT 339 Query: 344 ISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNE 403 + DR ++ +A I E+ R +AP+ PHK D+ + + K TEV L + H+ Sbjct: 340 LEDRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDP 399 Query: 404 KEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 + + QP F P+ FL+ G + S +++PF G R C+GE +AR ELFL +LQ F Sbjct: 400 QYFEQPGTFNPDHFLDANGA--LKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNF 457 Query: 464 DLE---VPDDGQL-PSLEGIPKV 482 + P D L P GI KV Sbjct: 458 SVSSSVAPKDIDLSPKESGIGKV 480 >2NNH-A nrPDB Length = 476 Score = 185 bits (469), Expect = 5e-47, Method: Compositional matrix adjust. Identities = 133/456 (29%), Positives = 223/456 (48%), Gaps = 17/456 (3%) Query: 19 KRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGH 78 K+ K P LP++G++ + + +F K YGP+++V G V+ Sbjct: 3 KKTSSKGKLPPGPTPLPIIGNMLQIDVKD-ICKSFTNFSKVYGPVFTVYFGMNPIVVFHG 61 Query: 79 HQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADS-GAHWQLHRRLAMATFALFKD 137 ++ KE LI G++FSGR I+ KG+ S G W+ RR ++ T F Sbjct: 62 YEAVKEALIDNGEEFSGR---GNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGM 118 Query: 138 GDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE-LN 196 G + +E + +E L + L D +F + A NVI + F + D L Sbjct: 119 GKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLT 178 Query: 197 VIQNYNEGI-IDNLSKDSLVDLVPWL-KIFPNKTLEKLKSHVKIRNDLLNKILENYKEKF 254 +++ +NE I N + + P L FP + LK+ R+ + K+ E ++ Sbjct: 179 LMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKE-HQASL 237 Query: 255 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314 ++ + +D + KM + N Q SE +N ++ T+ D+F AG ETT++ +++ Sbjct: 238 DVNNPRDFIDCFL-IKMEQEKDN----QKSEFNIEN-LVGTVADLFVAGTETTSTTLRYG 291 Query: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHK 374 L LL +P+V K+ EEID +G R+P + DR+ + +A + E+ R + P +PH Sbjct: 292 LLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHA 351 Query: 375 ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLP 434 D+ + + KGT ++ L ++ H++KE+ P+ F P FL+ G S ++P Sbjct: 352 VTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGN--FKKSDYFMP 409 Query: 435 FGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDD 470 F AG R C GE LAR ELFL + +LQ F+L+ DD Sbjct: 410 FSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDD 445 >4H1N-A nrPDB Length = 479 Score = 183 bits (464), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 124/453 (27%), Positives = 222/453 (49%), Gaps = 15/453 (3%) Query: 19 KRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGH 78 K+ K P LP++G+L + R G + + F +L++KYG +++V +G++ V++ Sbjct: 3 KKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRS-FLRLREKYGDVFTVYLGSRPVVVLCG 61 Query: 79 HQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDG 138 +E L+ + + FSGR ++A +D G+ FA+ G W+ RR ++AT F G Sbjct: 62 TDAIREALVDQAEAFSGRGKIAVVDPIFQG-YGVIFAN-GERWRALRRFSLATMRDFGMG 119 Query: 139 DQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDP---EL 195 + +E+ I +E L + L G +D + +N+I I F + DP L Sbjct: 120 KRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRL 179 Query: 196 NVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255 + + +I + S +LK FP T ++ +++ N + + +E ++ Sbjct: 180 LDLFFQSFSLISSFSSQVFELFSGFLKYFPG-THRQIYRNLQEINTFIGQSVEKHRATLD 238 Query: 256 SDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTL 315 + + +D + +M D D SE N ILT + +F AG ETT++ +++ Sbjct: 239 PSNPRDFIDVYL-LRMEKDKS----DPSSEFHHQNLILTVL-SLFAAGTETTSTTLRYGF 292 Query: 316 AFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKA 375 +L P V +++ +EI+Q +G R P + DR ++ +A I E+ RL + P +PH Sbjct: 293 LLMLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTV 352 Query: 376 NVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPF 435 D+ + + K TEV L + H+ + + P+ F P FL+ G + + ++PF Sbjct: 353 TKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGA--LKRNEGFMPF 410 Query: 436 GAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468 G R C+GE +AR ELFL +LQ F + P Sbjct: 411 SLGKRICLGEGIARTELFLFFTTILQNFSIASP 443 >3IBD-A nrPDB Length = 476 Score = 182 bits (463), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 123/422 (29%), Positives = 213/422 (50%), Gaps = 16/422 (3%) Query: 51 NNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRK 110 +F + ++KYG +++V +G + V++ + +E L+ K + FSGR ++A +D Sbjct: 34 KSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRG-Y 92 Query: 111 GIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFP 170 G+ FA+ G W++ RR ++ T F G + +E+ I +E L + L G +D +F Sbjct: 93 GVIFAN-GNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTF- 150 Query: 171 VFVAVT-NVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSK--DSLVDLVP-WLKIFPN 226 +F ++T N+I I F + D E + N +S L +L +LK FP Sbjct: 151 LFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPG 210 Query: 227 KTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSEL 286 + K+ +I N + +E ++E + +++DT + M + NA SE Sbjct: 211 AHRQVYKNLQEI-NAYIGHSVEKHRETLDPSAPRDLIDTYL-LHMEKEKSNA----HSEF 264 Query: 287 LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD 346 N L T+ +F AG ETT++ +++ +L P V +++Y EI+Q +G R P + D Sbjct: 265 SHQNLNLNTL-SLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHD 323 Query: 347 RNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW 406 R ++ EA I E+ R + PM +PH +S + + K TEV + L H+ + Sbjct: 324 RAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYF 383 Query: 407 HQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466 +PD F P+ FL+ G + + +++PF G R C+GE +AR ELFL +LQ F + Sbjct: 384 EKPDAFNPDHFLDANGA--LKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMA 441 Query: 467 VP 468 P Sbjct: 442 SP 443 >5E0E-A nrPDB Length = 463 Score = 182 bits (461), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 116/425 (27%), Positives = 212/425 (49%), Gaps = 14/425 (3%) Query: 47 GHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS 106 G N+F ++++KYG +++V +G + V++ + +E L+ + + FSGR +A ++ Sbjct: 21 GGFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTIAVVEPIF 80 Query: 107 NNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSID 166 G+ FA+ G W+ RR ++ T F G + +E+ I +E L + G +D Sbjct: 81 RG-YGVVFAN-GERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEFRKSQGAPLD 138 Query: 167 ISFPVFVAVTNVISLICFNTSYKNGDPELNVIQN--YNEGIIDNLSKDSLVDLVP-WLKI 223 +F N+I I F + D + + Y + + + +L +LK Sbjct: 139 PTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFSGFLKY 198 Query: 224 FPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQD 283 FP T ++ +++ D + + +E ++ + +DT + +M + N Q Sbjct: 199 FPG-THRQISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYL-LRMEKEKSN----QH 252 Query: 284 SELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPT 343 +E N +++ + +F AG ET+++ +++ +L P V +K+ +EIDQ +G R PT Sbjct: 253 TEFDHQNLVISVLS-LFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPT 311 Query: 344 ISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNE 403 + DR ++ EA I E+ R + P+ +PHK D+ + + K TEV L + H+ Sbjct: 312 LEDRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDP 371 Query: 404 KEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 + + QPD F P+ FL+ G + S +++PF G R C+GE +AR ELFL +LQ F Sbjct: 372 QYFEQPDTFNPDHFLDANGA--LKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNF 429 Query: 464 DLEVP 468 L P Sbjct: 430 SLSSP 434 >5YLW-A nrPDB Length = 495 Score = 170 bits (430), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 132/488 (27%), Positives = 230/488 (47%), Gaps = 50/488 (10%) Query: 4 LVALLLL--TLAYLFWPKRR-CPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY 60 L AL + T+ +L + +RR P +P P+VG++ L + H F KL K+Y Sbjct: 7 LAALFFIAATITFLSFRRRRNLPPGPFP-----YPIVGNM--LQLGANPHQVFAKLSKRY 59 Query: 61 GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH 120 GP+ S+ +G+ TVIV ++AKE+L + G+ FSGR + +++ + F + Sbjct: 60 GPLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDKISMGFLPVASE 119 Query: 121 WQLHRRLAMATFALFK----DGDQKLEKIICQEISTLCDML--ATHNGQSIDISFPVFVA 174 W+ R++ +F + Q L + Q++ L D + + +G+++DI F+ Sbjct: 120 WRDMRKICKEQ--MFSNQSMEASQGLRR---QKLQQLLDHVQKCSDSGRAVDIREAAFIT 174 Query: 175 VTNVISLICFNTSYKNGDPELNV-IQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLK 233 N++S F++ D + + + EG+ + + D P L+ F + Sbjct: 175 TLNLMSATLFSSQATEFDSKATMEFKEIIEGVATIVGVPNFADYFPILRPFDPQG----- 229 Query: 234 SHVKIRNDLL-NKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPD---------QD 283 VK R D+ K+L I L+ +++K + N D Q Sbjct: 230 --VKRRADVFFGKLLAK---------IEGYLNERLESKRANPNAPKKDDFLEIVVDIIQA 278 Query: 284 SEL-LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTP 342 +E L +H + D+F G +T T+ ++W ++ L+ NP +L E+ G + Sbjct: 279 NEFKLKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIV 338 Query: 343 TISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHN 402 S +L L+A I+EV+R+ P P+L+P KA D + + + KGT+++IN +A+ + Sbjct: 339 DESAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRD 398 Query: 403 EKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 W P+ F PERFL+ LPFG+G R C G LA + L + A L+ Sbjct: 399 PSIWTDPETFDPERFLD-NKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHN 457 Query: 463 FDLEVPDD 470 FD ++ DD Sbjct: 458 FDWKLEDD 465 >6DA2-A nrPDB Length = 487 Score = 120 bits (301), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 125/459 (27%), Positives = 205/459 (44%), Gaps = 36/459 (7%) Query: 32 LSLPLVGSLPFLPRHGHMHNNF----FKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLI 87 L +P LPFL H F + KKYG ++ G + + + + K VL+ Sbjct: 16 LGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLV 75 Query: 88 KKGKD-FSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKII 146 K+ F+ R + + I+ A+ W+ R L TF K +++ II Sbjct: 76 KECYSVFTNRRPFGPVGFM---KSAISIAED-EEWKRLRSLLSPTFTSGKL--KEMVPII 129 Query: 147 CQEISTLCDML--ATHNGQSIDISFPVFVAVT-NVISLICFNTSYKNGDPELNVIQNYNE 203 Q L L G+ + + VF A + +VI+ F + ++ + N + Sbjct: 130 AQYGDVLVRNLRREAETGKPVTLK-DVFGAYSMDVITSTSFGVN-------IDSLNNPQD 181 Query: 204 GIIDNLSK----DSLVDLVPWLKIFPN--KTLEKLKSHVKIR--NDLLNKILENYKEKFR 255 ++N K D L + +FP LE L V R + L K ++ KE Sbjct: 182 PFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRL 241 Query: 256 SDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTL 315 D+ + +D L ++ D+ N+ + + LSD ++ AG ETT+SV+ + + Sbjct: 242 EDTQKHRVDFL---QLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIM 298 Query: 316 AFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKA 375 L +P V++KL EEID + PT ++ L+ + E LRL P+A M + Sbjct: 299 YELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVC 357 Query: 376 NVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPF 435 D I + KG V+I +ALH + K W +P++F+PERF + I P + Y PF Sbjct: 358 KKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF-SKKNKDNIDPYI-YTPF 415 Query: 436 GAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLP 474 G+GPR+CIG A + L + +LQ F + + Q+P Sbjct: 416 GSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 454 >5VEU-A nrPDB Length = 480 Score = 115 bits (287), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 118/435 (27%), Positives = 195/435 (44%), Gaps = 45/435 (10%) Query: 58 KKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKD-FSGRPQMATLDIASNNRKGIAFAD 116 KKYG ++ G + + + + VL+K+ F+ R + + + I+ A+ Sbjct: 45 KKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFM---KSAISLAE 101 Query: 117 SGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDML--ATHNGQSIDISFPVFVA 174 W+ R L TF K +++ II Q L L G+ + + +F A Sbjct: 102 D-EEWKRIRSLLSPTFTSGKL--KEMFPIIAQYGDVLVRNLRREAEKGKPVTLK-DIFGA 157 Query: 175 VT-NVISLICFNTSYKN----GDPELNVIQNYNE-GIIDNLSKDSLVDLVPWL------- 221 + +VI+ F + + DP + + + + G +D L + L P+L Sbjct: 158 YSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLS--IILFPFLTPVFEAL 215 Query: 222 --KIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAG 279 +FP T+ L V + + K N K+K R D + M+D+ N+ Sbjct: 216 NVSLFPKDTINFLSKSV----NRMKKSRLNDKQKHRLDFLQLMIDS----------QNSK 261 Query: 280 PDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFS 339 + + LSD + AG ETT+SV+ +TL L +P V++KL +EID + Sbjct: 262 ETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNK 321 Query: 340 RTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWAL 399 PT ++ L+ + E LRL PVA + + D I + KG+ V+I +AL Sbjct: 322 APPTYDAVVQMEYLDMVVNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYAL 380 Query: 400 HHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWL 459 HH+ K W +P++F PERF + I P + Y PFG GPR+CIG A + L + + Sbjct: 381 HHDPKYWTEPEEFRPERFSKKKDS--IDPYI-YTPFGTGPRNCIGMRFALMNMKLALIRV 437 Query: 460 LQRFDLEVPDDGQLP 474 LQ F + + Q+P Sbjct: 438 LQNFSFKPCKETQIP 452 >3K9V-A nrPDB Length = 482 Score = 112 bits (279), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 102/451 (22%), Positives = 203/451 (45%), Gaps = 40/451 (8%) Query: 35 PLVGSLPFLPRHGHM---HNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGK 91 PL+GSL + G + H+ + KKYG I+ +++G+ +V +G L E L + Sbjct: 33 PLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLL-EALYRTES 91 Query: 92 DFSGRPQMATLDIASNNRK---GIAFADSGAHWQLHR----RLAMATFALFKDGDQKLEK 144 R ++ ++R G+ + G WQ R + M + K D+K+ + Sbjct: 92 AHPQRLEIKPWKAYRDHRNEAYGLMILE-GQEWQRVRSAFQKKLMKPVEIMK-LDKKINE 149 Query: 145 IICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEG 204 ++ + + D L G+ D+ + I L+ + + G Sbjct: 150 VLADFLERM-DELCDERGRIPDLYSELNKWSFESICLVLYEKRF---------------G 193 Query: 205 IIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLD 264 ++ +++ + + +K + + + + V++ L K+ + + + D+I + Sbjct: 194 LLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAW--DTIFKSVK 251 Query: 265 TLMQAKMNSDNGNAGPD-----QDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLL 319 + ++ + G D + LS + + ++ A VETT + + W L L Sbjct: 252 PCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLS 311 Query: 320 HNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDS 379 NPQ +++L +E+ + ++TP D + L+A ++E +RL P P + + Sbjct: 312 RNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVP-FTTRTLDKPT 370 Query: 380 SIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGP 439 +GE+A+ KGT + +N L +E + +F PER+L + I+P ++LPFG G Sbjct: 371 VLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQ--KEKKINP-FAHLPFGIGK 427 Query: 440 RSCIGEILARQELFLIMAWLLQRFDLEVPDD 470 R CIG LA +L L + W++Q++D+ D+ Sbjct: 428 RMCIGRRLAELQLHLALCWIIQKYDIVATDN 458 >4KPA-A nrPDB Length = 494 Score = 104 bits (260), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 71/237 (29%), Positives = 115/237 (48%), Gaps = 17/237 (7%) Query: 231 KLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDN 290 + + +K+ NDL++KI+ + K + D L+ +N + G E L D Sbjct: 228 QFQEDIKVMNDLVDKIIADRK------ASGEQSDDLLTHMLNGKDPETG-----EPLDDE 276 Query: 291 HILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRL 350 +I I AG ETT+ ++ + L FL+ NP V +K EE V P+ +L Sbjct: 277 NIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEA-ARVLVDPVPSYKQVKQL 335 Query: 351 LLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQP- 409 + + E LRL P AP + GE+ ++KG E+++ + LH ++ W Sbjct: 336 KYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDV 395 Query: 410 DQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466 ++F PERF NP+ P ++ PFG G R+CIG+ A E L++ +L+ FD E Sbjct: 396 EEFRPERFENPSAI----PQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFE 448 >3MDV-A nrPDB Length = 456 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 101/430 (23%), Positives = 185/430 (43%), Gaps = 38/430 (8%) Query: 49 MHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNN 108 + + F KKYGP+ V + KT+VIV + K+ L+ + + A + Sbjct: 12 LQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGER 71 Query: 109 RKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDML-ATHNGQS-ID 166 G + + H++ + A + L + ++ L ++L A +GQ+ + Sbjct: 72 LFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVS 131 Query: 167 ISFPVFVAVTNVISLICFN--TSYKNG--DPELNVIQNYNEGIIDNLSKDSLVDLVPWLK 222 + + ++++ F TS G P ++ EGI S+++L +P + Sbjct: 132 MQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGI--TASRNTLAKFLPGKR 189 Query: 223 IFPNKTLEKLKSHVKIRNDLLNKILENYK--EKFRSDSITNMLDTLMQAKMNSDNGNAGP 280 + E ++ ++ D + + E K E+ +D +T +L ++ G Sbjct: 190 KQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQIL--------KAEEGA--- 238 Query: 281 DQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSR 340 QD E L DN + F AG ET+ + + +T+ L P++ +L E+D+ +G R Sbjct: 239 -QDDEGLLDNFV-----TFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKR 292 Query: 341 TPTISDRNRLLLLEATIREVLRLRPVA---PMLIPHKANVDSSIGEFAVDKGTEVIINLW 397 D RL L ++E LRL P A L+ + +D V T ++ + + Sbjct: 293 YLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDG----VRVPGNTPLLFSTY 348 Query: 398 ALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMA 457 + + + P F P+RF G P +Y PF G RSCIG+ A+ E+ ++MA Sbjct: 349 VMGRMDTYFEDPLTFNPDRF----GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMA 404 Query: 458 WLLQRFDLEV 467 LLQR + + Sbjct: 405 KLLQRLEFRL 414 >6C94-A nrPDB Length = 497 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 97/394 (24%), Positives = 164/394 (41%), Gaps = 62/394 (15%) Query: 110 KGIAFADSGAHWQLHRRLAMATF---------ALFKDGD----QKLEKIICQEISTLCDM 156 KG+ D G W HR+L F A+F D +K EK C+ Sbjct: 102 KGLLVLD-GPKWFQHRKLLTPGFHYDVLKPYVAIFADSTRIMLEKWEKKACE-------- 152 Query: 157 LATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSK----- 211 G+S DI F V ++ ++ GD LN + + L+ Sbjct: 153 -----GKSFDI----FSDVGHMALDTLMKCTFGKGDSGLNHRDSSYYVAVSELTLLMQQR 203 Query: 212 -DSLV---DLVPWLKIFPNKTLEKLKSH-------VKIRNDLLNKILENYKEKFRSDSIT 260 DS D + WL + L ++ ++ R L E +EK ++ Sbjct: 204 IDSFQYHNDFIYWLTPHGRRFLRACRAAHDHTDRVIRQRKAALQD--EKEREKIQNRRHL 261 Query: 261 NMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLH 320 + LD L+ + G +G LSD + + G +TTTS + W L + Sbjct: 262 DFLDILLDVR-----GESGVQ-----LSDTDLRAEVDTFMFEGHDTTTSGISWFLYCMAL 311 Query: 321 NPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSS 380 P+ +++ EE+ + +G + D ++ L ++E RL P P + + S Sbjct: 312 YPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKPVSF 371 Query: 381 IGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPR 440 + ++ G+ + ++++ALH N W P+ F P RF +P + P +++PF AGPR Sbjct: 372 VDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRF-SPENSSGRHP-YAFIPFSAGPR 429 Query: 441 SCIGEILARQELFLIMAWLLQRFDLEVPDDGQLP 474 +CIG+ A E+ ++ A L RF+ V D +LP Sbjct: 430 NCIGQQFAMNEMKVVTALCLLRFEFSV-DPLRLP 462 >3EL3-A nrPDB Length = 467 Score = 86.3 bits (212), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 98/458 (21%), Positives = 187/458 (40%), Gaps = 40/458 (8%) Query: 18 PKRRCPGAKYPKSLLSLPLVGS-LPFLPRHGHMHNN---FFKLQKKYGPIYSVRMGTKTT 73 P+ R P A L P+ G +P L + + F + +G + +++G KT Sbjct: 8 PETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTV 67 Query: 74 VIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFA 133 V + +L + + +G P +L+ ++G+A A+ H + RR F Sbjct: 68 YAVTNPELTGALALNPDYHIAG-PLWESLE-GLLGKEGVATANGPLH-RRQRRTIQPAFR 124 Query: 134 LFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDP 193 L D I+ +E L + G+++D + F V + Y + Sbjct: 125 L--DAIPAYGPIMEEEAHALTERW--QPGKTVDATSESFRVAVRVAARCLLRGQYMDERA 180 Query: 194 ELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK 253 E + + + + +V L P ++ P + + + L+++I+ + Sbjct: 181 ERLCVALAT--VFRGMYRRMVVPLGPLYRL-PLPANRRFNDALADLHLLVDEIIAERRAS 237 Query: 254 FRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313 + ++L L++AK DNG+ + + I + I G ET S + W Sbjct: 238 GQKPD--DLLTALLEAK--DDNGDP--------IGEQEIHDQVVAILTPGSETIASTIMW 285 Query: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 373 L L +P+ ++ +E++ G R D +L I E +RLRP A ++ Sbjct: 286 LLQALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRP-AVWVLTR 343 Query: 374 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ-----PDQFMPERFLNPAGTQLISP 428 +A +S +G + + G ++I + +A+ + K + PD+++PER N P Sbjct: 344 RAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAAN-------VP 396 Query: 429 SVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466 + PF AG R C + + +L LI A L ++ E Sbjct: 397 KYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFE 434 >3JUS-A nrPDB Length = 461 Score = 82.0 bits (201), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 64/247 (25%), Positives = 120/247 (48%), Gaps = 22/247 (8%) Query: 233 KSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292 ++H +I+ D+ K ++ K + + I ++L TL+ A +D L+D+ + Sbjct: 207 RAHREIK-DIFYKAIQ--KRRQSQEKIDDILQTLLDATY----------KDGRPLTDDEV 253 Query: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNR-LL 351 + + AG T+++ W FL + ++KK Y E G + P D+ + L Sbjct: 254 AGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLN 313 Query: 352 LLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQ 411 LL+ I+E LRLRP M++ A ++ + + G +V ++ + W + Sbjct: 314 LLDRCIKETLRLRPPI-MIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLD 372 Query: 412 FMPERFL--NPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPD 469 F P+R+L NPA + +Y+PFGAG CIGE A ++ I + +L+ ++ ++ Sbjct: 373 FNPDRYLQDNPASGE----KFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL-I 427 Query: 470 DGQLPSL 476 DG P++ Sbjct: 428 DGYFPTV 434 >3S79-A nrPDB Length = 503 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 96/430 (22%), Positives = 179/430 (41%), Gaps = 42/430 (9%) Query: 58 KKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGR-PQMATLDIASNNRKGIAFAD 116 + YG V + + T+I+ + + I K +S R L + KGI F + Sbjct: 79 RVYGEFMRVWISGEETLIIS--KSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNN 136 Query: 117 SGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVT 176 + W+ R M AL G ++ + + + T D L +S +V V Sbjct: 137 NPELWKTTRPFFMK--ALSGPGLVRMVTVCAESLKTHLDRLEEVTNES------GYVDVL 188 Query: 177 NVISLICFNTSYK-------NGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTL 229 ++ + +TS + + IQ Y + L K + + WL K++ Sbjct: 189 TLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSV 248 Query: 230 EKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSD 289 + LK +++ I E + + + +D + + G+ L+ Sbjct: 249 KDLKDAIEVL------IAEKRRRISTEEKLEECMDFATELILAEKRGD---------LTR 293 Query: 290 NHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNR 349 ++ I ++ A +T + + + L + +P V++ + +EI +G R I D + Sbjct: 294 ENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQK 352 Query: 350 LLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQP 409 L ++E I E +R +PV L+ KA D I + V KGT +I+N+ +H E + +P Sbjct: 353 LKVMENFIYESMRYQPVVD-LVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEF-FPKP 410 Query: 410 DQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPD 469 ++F E F P + PFG GPR C G+ +A + I+ LL+RF ++ Sbjct: 411 NEFTLENFAKNV------PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQ 464 Query: 470 DGQLPSLEGI 479 + S++ I Sbjct: 465 GQCVESIQKI 474 >6AYB-A nrPDB Length = 466 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 73/288 (25%), Positives = 130/288 (45%), Gaps = 23/288 (7%) Query: 191 GDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHV-KIRNDLLNKILEN 249 GD + N G + + D + L + P +K + V +I +LL+K E Sbjct: 163 GDEVRQYLSEKNLGKLYHDIDDGISPLSFFYPSLPAPKRDKARKAVGEIFQELLDKRREE 222 Query: 250 YK---EKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNH-ILTTIGDIFGAGVE 305 +K E+ +S +++D L+ K +D + L+D H I I +F AG Sbjct: 223 HKKHPERLLDESKMDVVDHLLTQKY----------KDGQELTDVHRIGILIAGLF-AGQH 271 Query: 306 TTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRP 365 T++ WTL ++ N +V +K+ +E ++ +G + ++ LEA ++E LR+ P Sbjct: 272 TSSITSSWTLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYP 331 Query: 366 VAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQL 425 M++ A ++ + KG ++++ + PD F PER + Sbjct: 332 PLIMIM-RMARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERLTERKEHEK 390 Query: 426 ISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE----VPD 469 +PFGAG CIGE A ++ I++ LL+ FD+E +PD Sbjct: 391 F--KYGAVPFGAGRHKCIGENFALLQVKSIISILLRYFDMEYIGKIPD 436 >5JLC-A nrPDB Length = 515 Score = 72.0 bits (175), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 66/269 (24%), Positives = 116/269 (43%), Gaps = 28/269 (10%) Query: 223 IFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITN--MLDTLMQAKMNSDNGNAGP 280 +FPN LE + + + + KE+ + I N ++D LM+ NS Sbjct: 224 VFPNLPLEHYRKRDHAQQAISGTYMSLIKERREKNDIQNRDLIDELMK---NSTY----- 275 Query: 281 DQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGF-S 339 +D ++D I + + G T+ + W L L P V+++LY+E + + + Sbjct: 276 -KDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQEQMRVLNNDT 334 Query: 340 RTPTISDRNRLLLLEATIREVLRLR-PVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWA 398 + T D + LL I+E LRL P+ + +V + V + V+++ Sbjct: 335 KELTYDDLQNMPLLNQMIKETLRLHHPLHSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGY 394 Query: 399 LHHNEKEWHQPDQFMPERFLNPA-------------GTQLISPSVS--YLPFGAGPRSCI 443 H E+ + +P++F R+ A G IS VS YLPFG G CI Sbjct: 395 THLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCI 454 Query: 444 GEILARQELFLIMAWLLQRFDLEVPDDGQ 472 GE+ A +L ++M+ ++ P +G+ Sbjct: 455 GELFAYCQLGVLMSIFIRTMKWRYPTEGE 483 >3MZS-A nrPDB Length = 486 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 100/446 (22%), Positives = 189/446 (42%), Gaps = 60/446 (13%) Query: 58 KKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGR---PQMATLDIASNNRKGIAF 114 +KYGPIY ++G +V + H + + +G + R P G+ F Sbjct: 45 QKYGPIYREKLGNLESVYIIHPEDVAHLFKFEG-SYPERYDIPPWLAYHRYYQKPIGVLF 103 Query: 115 ADSGAHWQLHRRLAMATFALFKDGDQKLEKI---ICQEISTLCDMLATHNGQSI------ 165 SG W+ R+ + T + + + + + Q+ +L G Sbjct: 104 KKSGT-WK-KDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIK 161 Query: 166 -DISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKD-SLVDLVPWL-K 222 D+ F ++TNV+ + +PE Q + + + L+++ P L + Sbjct: 162 EDLFHFAFESITNVMFGERLGMLEETVNPE---AQKFIDAVYKMFHTSVPLLNVPPELYR 218 Query: 223 IFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSD--------SITNMLDTLMQAKMNSD 274 +F KT + HV + + NK E Y E F D + +L L+++ Sbjct: 219 LFRTKTW---RDHVAAWDTIFNKA-EKYTEIFYQDLRRKTEFRNYPGILYCLLKS----- 269 Query: 275 NGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQ 334 + LL D + I ++ GV TT+ ++W L + + V++ L EE+ Sbjct: 270 --------EKMLLED--VKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLN 319 Query: 335 NVGFSRTPTISDRNRLL----LLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGT 390 +R D +++L LL+A+I+E LRL P++ L + + D + ++ + T Sbjct: 320 ----ARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPES-DLVLQDYLIPAKT 374 Query: 391 EVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQ 450 V + ++A+ + + PD+F P R+L+ LI L FG G R C+G +A Sbjct: 375 LVQVAIYAMGRDPAFFSSPDKFDPTRWLS-KDKDLI--HFRNLGFGWGVRQCVGRRIAEL 431 Query: 451 ELFLIMAWLLQRFDLEVPDDGQLPSL 476 E+ L + +L+ F +E+ G + ++ Sbjct: 432 EMTLFLIHILENFKVEMQHIGDVDTI 457 >2VE3-A nrPDB Length = 444 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 92/413 (22%), Positives = 172/413 (41%), Gaps = 40/413 (9%) Query: 55 KLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAF 114 K Q+++GPI+ R+ K + + + + K+ + F ++T + N A Sbjct: 38 KRQQQFGPIFKTRLFGKNVIFISGALANRFLFTKEQETFQATWPLSTRILLGPN----AL 93 Query: 115 ADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVA 174 A RR + L + D L K+ + L + I +P Sbjct: 94 ATQMGEIHRSRRKILYQAFLPRTLDSYLPKMD----GIVQGYLEQWGKANEVIWYPQLRR 149 Query: 175 VTNVISLICFNTSYKNGDPEL-NVIQNYNEGIIDNLSKDSLVDLVPWLKI-FPNKTLEKL 232 +T ++ F + +P+L + Y +G+ L I PN K Sbjct: 150 MTFDVAATLFMGEKVSQNPQLFPWFETYIQGLFS-------------LPIPLPNTLFGKS 196 Query: 233 KSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292 + + L KI++ +++ S+ + L L+ A+ D +++ LS + Sbjct: 197 QRARALLLAELEKIIKARQQQPPSEE--DALGILLAAR----------DDNNQPLSLPEL 244 Query: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352 I + AG ET TS + L + +++++ +E ++ + S+ T ++ Sbjct: 245 KDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQNK-LQLSQELTAETLKKMPY 303 Query: 353 LEATIREVLRLRPVAPMLIPHKANV-DSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQ 411 L+ ++EVLRL P P+ + + D F KG V + H + + P++ Sbjct: 304 LDQVLQEVLRLIP--PVGGGFRELIQDCQFQGFHFPKGWLVSYQISQTHADPDLYPDPEK 361 Query: 412 FMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFD 464 F PERF P G+ +P +++PFG G R C+G+ AR E+ L L+Q+FD Sbjct: 362 FDPERF-TPDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKLFATRLIQQFD 413 >4WMZ-A nrPDB Length = 539 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 64/270 (23%), Positives = 116/270 (42%), Gaps = 27/270 (10%) Query: 223 IFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITN--MLDTLMQAKMNSDNGNAGP 280 +FPN LE + + + + KE+ +++ I + ++D+LM+ NS Sbjct: 242 VFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMK---NSTY----- 293 Query: 281 DQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFS 339 +D ++D I + + G T+ + W L L P V+++LYEE + + G Sbjct: 294 -KDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGK 352 Query: 340 RTPTISDRNRLLLLEATIREVLRLR-PVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWA 398 + T + LL TI+E LR+ P+ + ++ + + G V+++ Sbjct: 353 KELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGY 412 Query: 399 LHHNEKEWHQPDQFMPERFLNPA------------GTQLISPSVS--YLPFGAGPRSCIG 444 H ++ + QF R+ N + G IS VS YLPFG G CIG Sbjct: 413 THLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIG 472 Query: 445 EILARQELFLIMAWLLQRFDLEVPDDGQLP 474 E A +L ++M+ ++ P+ +P Sbjct: 473 EHFAYCQLGVLMSIFIRTLKWHYPEGKTVP 502 >2W0A-A nrPDB Length = 455 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 63/262 (24%), Positives = 121/262 (46%), Gaps = 25/262 (9%) Query: 212 DSLVDLVPWLKIFPNKTLEKLKSH-VKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAK 270 D L + P+L I + ++ ++ V + D++N + N +SD +MLD L+ K Sbjct: 177 DPLAYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTD-KSDR--DMLDVLIAVK 233 Query: 271 MNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYE 330 + D+ + + I +F AG T++ WTL L+ + + + Sbjct: 234 AETGTPRFSADEITGMF--------ISMMF-AGHHTSSGTASWTLIELMRHRDAYAAVID 284 Query: 331 EIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVD--- 387 E+D+ G R+ + ++ LE ++E LRL P P++I + + GEF V Sbjct: 285 ELDELYGDGRSVSFHALRQIPQLENVLKETLRLHP--PLIILMRV----AKGEFEVQGHR 338 Query: 388 --KGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGE 445 +G V + + +++ P F+P R+ P L++ +++PFGAG C+G Sbjct: 339 IHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLN-RWTWIPFGAGRHRCVGA 397 Query: 446 ILARQELFLIMAWLLQRFDLEV 467 A ++ I + LL+ ++ E+ Sbjct: 398 AFAIMQIKAIFSVLLREYEFEM 419 >6M7X-A nrPDB Length = 484 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 98/206 (47%), Gaps = 17/206 (8%) Query: 250 YKEKFRS-DSITNMLDTLMQAKMNSDNGNAGPDQDSEL---------LSDNHILTTIGDI 299 +KE F + D I D +Q K+ + + P Q + + LS + I ++ Sbjct: 230 WKEHFEAWDCIFQYGDNCIQ-KIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMEL 288 Query: 300 FGAGVETTTSVVKWTLAFLLHNPQVKKKLYEE-IDQNVGFSRTPTISDRNRLLLLEATIR 358 V+TT + TL L NP V++ L +E + S P + L LL A ++ Sbjct: 289 TAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT-TELPLLRAALK 347 Query: 359 EVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418 E LRL PV + + A+ D + + + GT V + L++L N + +P+++ P+R+L Sbjct: 348 ETLRLYPVG-LFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWL 406 Query: 419 NPAGTQLISPSVSYLPFGAGPRSCIG 444 + G+ + ++PFG G R C+G Sbjct: 407 DIRGS---GRNFYHVPFGFGMRQCLG 429 >2WX2-A nrPDB Length = 473 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 63/264 (23%), Positives = 115/264 (43%), Gaps = 34/264 (12%) Query: 217 LVPWLKIFPNKTLEKLKSHVKIRNDLLNKIL--ENYKEKFRSDSITNMLDTLMQAKMNSD 274 +PWL P + + +L +I+ +E + ++ +++L L++A Sbjct: 200 FMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNTSDLLGGLLKAVY--- 256 Query: 275 NGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKK---KLYEE 331 +D +S + + I AG T+T W++ L+H P+ KK KL++E Sbjct: 257 -------RDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMH-PKNKKWLDKLHKE 308 Query: 332 IDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHK-ANVDSSIGEFAVDKGT 390 ID+ + D + E +RE +R P P+L+ + + +G + V KG Sbjct: 309 IDEFPAQLNYDNVMDE--MPFAERCVRESIRRDP--PLLMVMRMVKAEVKVGSYVVPKGD 364 Query: 391 EVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQ 450 + + HH+E+ + P + PER G +++ FGAG CIG+ A Sbjct: 365 IIACSPLLSHHDEEAFPNPRLWDPERDEKVDG--------AFIGFGAGVHKCIGQKFALL 416 Query: 451 ELFLIMAWLLQRFDL-----EVPD 469 ++ I+A + +D EVPD Sbjct: 417 QVKTILATAFREYDFQLLRDEVPD 440 >3N9Z-A nrPDB Length = 487 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 46/184 (25%), Positives = 91/184 (49%), Gaps = 10/184 (5%) Query: 287 LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD 346 +S I + ++ GV+TT+ ++W L + N +V+ L E+ ++ + Sbjct: 271 MSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATM 330 Query: 347 RNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW 406 + LL+A+I+E LRL P++ L + N D + ++ + T V + ++AL + Sbjct: 331 LQLVPLLKASIKETLRLHPISVTLQRYLVN-DLVLRDYMIPAKTLVQVAIYALGREPTFF 389 Query: 407 HQPDQFMPERFLNPAGTQLISPSVSY---LPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 P+ F P R+L+ +++Y L FG G R C+G +A E+ + + +L+ F Sbjct: 390 FDPENFDPTRWLSK------DKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENF 443 Query: 464 DLEV 467 +E+ Sbjct: 444 RVEI 447 >6CR2-A nrPDB Length = 477 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 98/456 (21%), Positives = 174/456 (38%), Gaps = 63/456 (13%) Query: 53 FFKLQKKYGPIYS-VRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKG 111 FF + KYG I++ + +G KTTV +G + +L K +D + L R Sbjct: 30 FFDCRAKYGDIFTFILLGKKTTVYLGT-KGNDFILNGKLRDVCAEEVYSPLTTPVFGRHV 88 Query: 112 IAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPV 171 + + +L + + L D + +I E+ + G V Sbjct: 89 VYDCPNA---KLMEQKKFVKYGLTSDALRSYVPLITDEVESFVKNSPAFQGHK-----GV 140 Query: 172 FVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEK 231 F + + + S E +++ + L + + P + P L Sbjct: 141 FDVCKTIAEITIYTASRSLQGKE---VRSKFDSTFAELYHNLDMGFAPINFMLPWAPL-- 195 Query: 232 LKSHVKIRNDLLNKILENYKEKFRS-----------DSITNMLDTLMQAKMNSDNGNAGP 280 H + R+ K+ E Y E ++ D + N++ + + NG P Sbjct: 196 --PHNRKRDAAQRKLTETYMEIIKARRQAGSKKDSEDMVWNLMSCVYK------NGTPVP 247 Query: 281 DQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSR 340 D++ I + + AG +++S W + L P + ++LY+E + +G Sbjct: 248 DEE--------IAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLGSDL 299 Query: 341 TPTISDRNRLLLLEA-TIREVLRLR-PVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWA 398 P D + L L A I+E LRL P+ ++ K + + + V+ + Sbjct: 300 PPLTYDNLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNVLSSPGV 359 Query: 399 LHHNEKEWHQPDQFMPERF-LNPA-----------GTQLISPSVS--YLPFGAGPRSCIG 444 +E+ + P ++ P R+ N A G L+S + YLPFGAG CIG Sbjct: 360 TARSEEHFPNPLEWNPHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHRCIG 419 Query: 445 EILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480 E A +L I A L++ F LP ++GIP Sbjct: 420 EQFAYLQLGTITAVLVRLFRFR-----NLPGVDGIP 450 >2IJ7-A nrPDB Length = 396 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 54/186 (29%), Positives = 82/186 (44%), Gaps = 34/186 (18%) Query: 290 NHILTTIG-DIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348 + + TIG FGAGV +T S + L L+ PQ++ L+E+ + Sbjct: 220 DELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPE--------------- 264 Query: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408 L+ A + E+LR+ +P A D +G+ V KG V++ L + Sbjct: 265 ---LIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGAN-------- 313 Query: 409 PDQFMPERFLNPAGTQLISPS-VSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF---D 464 F PE F NP +L P+ S+L FG G C G L R+ + + LL++ D Sbjct: 314 ---FDPEHFPNPGSIELDRPNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVD 370 Query: 465 LEVPDD 470 L VP D Sbjct: 371 LAVPID 376 >2X2N-A nrPDB Length = 475 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 49/198 (24%), Positives = 85/198 (42%), Gaps = 24/198 (12%) Query: 282 QDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVK-----KKLYEEIDQNV 336 +D +S + + I AG T++ W++ L+H VK +K EE + Sbjct: 257 RDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFPAQL 316 Query: 337 GFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINL 396 ++ + + E RE +R P ML+ K D +G + V KG + + Sbjct: 317 NYNNV-----MDEMPFAERCARESIRRDPPLLMLM-RKVMADVKVGSYVVPKGDIIACSP 370 Query: 397 WALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIM 456 HH+E+ + +P ++ PER G +++ FGAG CIG+ ++ I+ Sbjct: 371 LLSHHDEEAFPEPRRWDPERDEKVEG--------AFIGFGAGVHKCIGQKFGLLQVKTIL 422 Query: 457 AWLLQRFDL-----EVPD 469 A + +D EVPD Sbjct: 423 ATAFRSYDFQLLRDEVPD 440 >4ZGX-A nrPDB Length = 489 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 42/149 (28%), Positives = 75/149 (50%), Gaps = 6/149 (4%) Query: 298 DIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEE-IDQNVGFSRTPTISDRNRLLLLEAT 356 ++ V+TT + TL L NP V++ L +E + S P + L LL A Sbjct: 287 ELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKAT-TELPLLRAA 345 Query: 357 IREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPER 416 ++E LRL PV + + + D + + + GT V + L++L N + +P+++ P+R Sbjct: 346 LKETLRLYPVG-LFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 404 Query: 417 FLNPAGTQLISPSVSYLPFGAGPRSCIGE 445 +L+ G+ + ++PFG G R C+G Sbjct: 405 WLDIRGS---GRNFHHVPFGFGMRQCLGR 430 >5FSA-A nrPDB Length = 490 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 56/226 (24%), Positives = 88/226 (38%), Gaps = 46/226 (20%) Query: 282 QDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEI----DQNVG 337 +D ++D I + I G T+ S W L L P ++ +Y+E+ + G Sbjct: 245 KDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGG 304 Query: 338 FSRTPTISDRNRLLLLEATIREVLRL---------RPVAPMLIPHKANVDSSIGEFAVDK 388 T D +L + TI+E LR+ + P+ IP + V K Sbjct: 305 DLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPET--------NYIVPK 356 Query: 389 GTEVIINLWALHHNEKEWHQPDQFMPERFLNPA----------------GTQLISPSVS- 431 G V+++ H +E+ + P+ F P R+ A G +S VS Sbjct: 357 GHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSS 416 Query: 432 -YLPFGAGPRSCIGEILARQELFLIMA-------WLLQRFDLEVPD 469 YLPFG G CIGE A +L I+ W + + + PD Sbjct: 417 PYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPD 462 >6FYJ-A nrPDB Length = 421 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 38/144 (26%), Positives = 68/144 (47%), Gaps = 13/144 (9%) Query: 357 IREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPER 416 ++EV R P P ++ D + + ++GT +++L+ +H+ + W PD F P+R Sbjct: 284 VQEVRRFYPFFPFVVA-LVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDR 342 Query: 417 FLNPAGTQLISPSVSYLPFGAGP----RSCIGEILARQELFLIMAWLLQRFDLEVPDDG- 471 F G+ S++P G G C GE + + + + + +L R D EVPD Sbjct: 343 FAKWEGSPF-----SFIPQGGGDYFMGHRCAGEWVTIEVMKVSLDYLTNRMDYEVPDQDL 397 Query: 472 --QLPSLEGIPKVVFLIDSFKVKI 493 + S+ IP +I + K +I Sbjct: 398 SFSMASMPSIPHSKVVIKNVKKRI 421 >3L4D-A nrPDB Length = 453 Score = 58.2 bits (139), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 60/256 (23%), Positives = 115/256 (44%), Gaps = 26/256 (10%) Query: 217 LVPWLKIFPNKTLEKLKSHVKIRNDLLNKIL-ENYKEKFRSDSIT-NMLDTLMQAKMNSD 274 +PW+ P + + D+L++I+ KE+ + D+ T ++L L+ A Sbjct: 186 FLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEEAQKDTNTSDLLAGLLGAVY--- 242 Query: 275 NGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKK---KLYEE 331 +D +S + + I AG T+T W+L L+ +P+ K+ KL++E Sbjct: 243 -------RDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLM-DPRNKRHLAKLHQE 294 Query: 332 IDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTE 391 ID+ + + + E RE +R P ML+ K +G++ V +G Sbjct: 295 IDEFPAQLNYDNVMEE--MPFAEQCARESIRRDPPLVMLM-RKVLKPVQVGKYVVPEGDI 351 Query: 392 VIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQE 451 + + H +E+ + P ++ PER +L+ + + FGAG CIGE + Sbjct: 352 IACSPLLSHQDEEAFPNPREWNPER-----NMKLVDGA--FCGFGAGVHKCIGEKFGLLQ 404 Query: 452 LFLIMAWLLQRFDLEV 467 + ++A +L+ +D E+ Sbjct: 405 VKTVLATVLRDYDFEL 420 >6A7J-A nrPDB Length = 411 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 86/220 (39%), Gaps = 44/220 (20%) Query: 263 LDTLMQAKMNSDNGNAGPD---------QDSELLSDNHILTTIGDIFGAGVETTTS-VVK 312 L TL + N G D +D + L+D IL T+ I AG ETT S +V Sbjct: 192 LGTLFTKIVEEKKANPGDDLTSALIAASEDGDHLTDEEILNTLQLIIAAGHETTISLIVN 251 Query: 313 WTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIP 372 A +H Q KK L EI E I E LR ++ Sbjct: 252 VVEALAIHPEQRKKVLSGEIP-------------------WEGVIEETLRWNTPTSHVLI 292 Query: 373 HKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWH-QPDQFMPERFLNPAGTQLISPSVS 431 A D +G+ + KG ++++ AL +E+++ F R N Sbjct: 293 RFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGPTAGDFDATRTPN-----------R 341 Query: 432 YLPFGAGPRSCIGEILARQELFLIMAWLLQRF---DLEVP 468 ++ FG GP C G L+R E + + L +RF DL VP Sbjct: 342 HIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVP 381 >3NC3-A nrPDB Length = 441 Score = 55.1 bits (131), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 44/177 (24%), Positives = 77/177 (43%), Gaps = 20/177 (11%) Query: 287 LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD 346 LSD IL I ++ A E + + LL+NP+ ++D Sbjct: 254 LSDKDILALILNVLLAATEPADKTLALMIYHLLNNPE---------------QMNDVLAD 298 Query: 347 RNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW 406 R+ L+ I E LR +P LIP + + D+ +G + K T V + A + + + + Sbjct: 299 RS---LVPRAIAETLRYKPPV-QLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAF 354 Query: 407 HQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 QPD F R + S + +L FG+G +C+G A+ E+ ++ +L + Sbjct: 355 EQPDVFNIHR-EDLGIKSAFSGAARHLAFGSGIHNCVGTAFAKNEIEIVANIVLDKM 410 >4YT3-A nrPDB Length = 410 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 46/182 (25%), Positives = 85/182 (46%), Gaps = 30/182 (16%) Query: 283 DSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTP 342 D E+ +D+ ++ T I GAGVETT+ ++ + LL++ K++Y+E+ +N Sbjct: 224 DGEMFTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYD---DKEVYQELHEN------- 273 Query: 343 TISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHN 402 L L+ + E+LR R + + D+ + + +G V++ + A + + Sbjct: 274 -------LDLVPQAVEEMLRFR-FNLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMD 325 Query: 403 EKEWHQPDQFMPERFLNPAGTQLISP-SVSYLPFGAGPRSCIGEILARQELFLIMAWLLQ 461 E E F +P + P + +L FG GP C+G LAR E + + L+ Sbjct: 326 E-----------EMFEDPFTLNIHRPNNKKHLTFGNGPHFCLGAPLARLEAKIALTAFLK 374 Query: 462 RF 463 +F Sbjct: 375 KF 376 >1WIY-A nrPDB Length = 389 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 51/183 (27%), Positives = 78/183 (42%), Gaps = 31/183 (16%) Query: 287 LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD 346 L L+ + AG ET S + W+ L H P +K++ E + + Sbjct: 206 LPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRVAESEEAAL---------- 255 Query: 347 RNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWA---LHHNE 403 A +E LRL P A +L + +GE + +GT ++++ + L+ E Sbjct: 256 --------AAFQEALRLYPPAWILT-RRLERPLLLGEDRLPQGTTLVLSPYVTQRLYFPE 306 Query: 404 KEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 E F PERFL GT PS Y PFG G R C+G A E +++ +RF Sbjct: 307 GE-----AFQPERFLAERGT----PSGRYFPFGLGQRLCLGRDFALLEGPIVLRAFFRRF 357 Query: 464 DLE 466 L+ Sbjct: 358 RLD 360 >4RM4-A nrPDB Length = 396 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 54/219 (24%), Positives = 93/219 (42%), Gaps = 46/219 (21%) Query: 281 DQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSR 340 ++ E LS ++ + AG ETTT+++ + +L P V YEE+ Sbjct: 218 EETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGV----YEEL-------- 265 Query: 341 TPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALH 400 R+ L+ + E LR R AP+L A D+ IG + +G V+ + + + Sbjct: 266 ------RSHPELMPQAVEEALRFRAPAPVL-RRIAKRDTEIGGHLIKEGDMVLAFVASAN 318 Query: 401 HNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLL 460 +E ++ +P F R NP ++ FG G C+G LAR E + + L+ Sbjct: 319 RDEAKFDRPHMFDIRRHPNP-----------HIAFGHGIHFCLGAPLARLEANIALTSLI 367 Query: 461 QRFDLEVPDDGQLPSLEGIP------KVVFLIDSFKVKI 493 F P +E + V++ + SF+VK+ Sbjct: 368 SAF----------PHMECVSITPIENSVIYGLKSFRVKM 396 >3TYW-A nrPDB Length = 417 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 46/176 (26%), Positives = 76/176 (43%), Gaps = 29/176 (16%) Query: 287 LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD 346 ++ +L+T+G AG ETTTS++ + LL P++ +L ++ D Sbjct: 234 VTTEQLLSTLGITINAGRETTTSMIALSTLLLLDRPELPAELRKDPD------------- 280 Query: 347 RNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW 406 L+ A + E+LR+ VA + A D + V VI L +H+ Sbjct: 281 -----LMPAAVDELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHD---- 331 Query: 407 HQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 PE+F +P ++ FG G C+G+ LAR EL + + LL+R Sbjct: 332 -------PEQFDDPERVDFHRTDNHHVAFGYGVHQCVGQHLARLELEVALETLLRR 380 >6A7I-A nrPDB Length = 411 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 54/218 (24%), Positives = 93/218 (42%), Gaps = 44/218 (20%) Query: 255 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314 R++ ++ L+ A N D+ L+D I+ T+ I AG ETT S++ Sbjct: 204 RTNPGDDLTSALIAASENGDH-----------LTDEEIVNTLQLIIAAGHETTISLIVNV 252 Query: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHK 374 + L +P+ +KK+ ++ +G+ + I E LR ++ Sbjct: 253 VEALQTHPEQRKKV---LNGEIGW---------------DGVIEETLRWNTPTSHVLIRF 294 Query: 375 ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWH-QPDQFMPERFLNPAGTQLISPSVSYL 433 A D +G+ + KG +II+ AL +E+++ +F R N ++ Sbjct: 295 ATEDIEVGDKILPKGEGLIISFGALGRDEEQYGPTAGEFDATRTPN-----------RHI 343 Query: 434 PFGAGPRSCIGEILARQELFLIMAWLLQRF---DLEVP 468 FG GP C G L+R E + + L +RF DL VP Sbjct: 344 AFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVP 381 >5L1U-A nrPDB Length = 401 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 52/190 (27%), Positives = 79/190 (41%), Gaps = 34/190 (17%) Query: 287 LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD 346 LSD I + G ETT + LL NP + +L E+ Sbjct: 220 LSDADIAHLGNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAEDPG------------- 266 Query: 347 RNRLLLLEATIREVLRLR---PVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNE 403 L A + E+LRL + LIP A+ D ++GE + G V++ + A ++++ Sbjct: 267 -----LAPAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDD 321 Query: 404 KEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR- 462 + + F R + P S+L FG G R CIG LAR EL + L +R Sbjct: 322 RAFPDGGLFDLTR---------VRPR-SHLAFGHGARHCIGRTLARIELTAVFERLFRRL 371 Query: 463 --FDLEVPDD 470 L VP++ Sbjct: 372 PDLRLAVPEE 381 >5M0P-A nrPDB Length = 428 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 44/177 (24%), Positives = 69/177 (38%), Gaps = 32/177 (18%) Query: 315 LAFLLH----NPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPML 370 ++F LH NP ++K+ E D F++ EV R P P L Sbjct: 260 VSFGLHAMNENPITREKIKSEPDYAYKFAQ------------------EVRRYYPFVPFL 301 Query: 371 IPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSV 430 P KA VD + G + ++++ H+E W P++F PERF G+ Sbjct: 302 -PGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRPERFETWDGSPF----- 355 Query: 431 SYLPFGAGP----RSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVV 483 +P G G C GE + + M + ++ +VP+ L IP V Sbjct: 356 DLIPQGGGDYWTNHRCAGEWITVIIMEETMKYFAEKITYDVPEQDLEVDLNSIPGYV 412 >3R9C-A nrPDB Length = 418 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 47/183 (25%), Positives = 75/183 (40%), Gaps = 30/183 (16%) Query: 281 DQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSR 340 ++ + L+++ I+ T + AG ETT +++ +L P L Sbjct: 235 EESGDQLTEDEIIATCNLLLIAGHETTVNLIANAALAMLRTPGQWAAL------------ 282 Query: 341 TPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALH 400 +D +R A I E +R P L+ A D +IG V KG +++ L A H Sbjct: 283 ---AADGSRA---SAVIEETMRYDPPV-QLVSRYAGDDLTIGTHTVPKGDTMLLLLAAAH 335 Query: 401 HNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLL 460 + PD+F P+R + +L FG G C+G LAR E + + L Sbjct: 336 RDPTIVGAPDRFDPDRA-----------QIRHLGFGKGAHFCLGAPLARLEATVALPALA 384 Query: 461 QRF 463 RF Sbjct: 385 ARF 387 >5L94-A nrPDB Length = 410 Score = 51.6 bits (122), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 58/238 (24%), Positives = 105/238 (44%), Gaps = 43/238 (18%) Query: 227 KTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSEL 286 +TLEKL+ ND L E+ R+ +++ L+QAK ++ + Sbjct: 178 ETLEKLQQEKMKANDELETYFYRIIEEKRTRPGDDIISVLLQAK-----------EEGKQ 226 Query: 287 LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD 346 L+D I+ + AG ETTT+++ T+ L+ + ++L E + Sbjct: 227 LTDEEIVGFSILLLIAGNETTTNLISNTIYCLMEDKASFERLKREKE------------- 273 Query: 347 RNRLLLLEATIREVLRLRPVAPMLIPHK-ANVDSSIGEFAVDKGTEVIINLWALHHNEKE 405 LL + I EVLR R +P+ H+ D ++ + G V+ + + H + + Sbjct: 274 -----LLPSGIEEVLRYR--SPVQALHRIVKEDVTLAGKKLKAGEHVVPWMGSAHRDAEY 326 Query: 406 WHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 + P+ F +R P+V ++ FG G C+G LAR E +++A L+ R+ Sbjct: 327 FEDPEVFKIDR----------KPNV-HMAFGRGIHFCLGAPLARIEAKIMLAELIDRY 373 >6B11-A nrPDB Length = 440 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 53/214 (24%), Positives = 88/214 (41%), Gaps = 47/214 (21%) Query: 261 NMLDTLMQAKMNSDNGNA-----------GPDQDSELLSDNHILTTIGDIFGAGVETTTS 309 + LD L+ K ++G+ G +++L DN +L + AG ETT S Sbjct: 233 DYLDRLISGKTGRESGDGMLGSMVAQARGGGLSHADVL-DNAVL-----LLAAGHETTAS 286 Query: 310 VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPM 369 +V ++ LL +P + E+ N G LL + E+LR +A Sbjct: 287 MVTMSVLVLLQHPTA----WRELTVNPG--------------LLPGAVDELLRYLSIADG 328 Query: 370 LIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPS 429 L A D I + G ++ L A + +E + +P+ F R Sbjct: 329 LR-RSATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHRSAR---------- 377 Query: 430 VSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 ++ FG GP C+G+ LAR EL + + +L+R Sbjct: 378 -RHVAFGYGPHQCLGQNLARMELEVALGAVLERL 410 >5XNT-A nrPDB Length = 411 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 44/182 (24%), Positives = 84/182 (46%), Gaps = 30/182 (16%) Query: 283 DSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTP 342 D E+ +D+ ++ T I GAGVETT+ ++ + LL++ K++Y+E+ +N+ Sbjct: 224 DGEMFTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYD---DKEVYQELHENLD----- 275 Query: 343 TISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHN 402 L+ + E+LR R + + D+ + + +G V++ + A + + Sbjct: 276 ---------LVPQAVEEMLRYR-FNLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLD 325 Query: 403 EKEWHQPDQFMPERFLNPAGTQLISP-SVSYLPFGAGPRSCIGEILARQELFLIMAWLLQ 461 E E F + + P + +L FG GP C+G LAR E + + L+ Sbjct: 326 E-----------EMFEDAFTLNIHRPNNKKHLTFGNGPHFCLGAPLARLEAKIALTTFLK 374 Query: 462 RF 463 +F Sbjct: 375 KF 376 >5LIE-A nrPDB Length = 414 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 52/209 (24%), Positives = 85/209 (40%), Gaps = 38/209 (18%) Query: 255 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314 R++ +ML + A ++ D D+ LSD + +F AG ETT + + Sbjct: 214 RAEPADDMLSVVANATID--------DPDAPALSDAELYLFFHLLFSAGAETTRNSIAGG 265 Query: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHK 374 L L NP + L R+ LL I E++R +P Sbjct: 266 LLALAENPDQLQTL------------------RSDFELLPTAIEEIVRWTSPSPSKR-RT 306 Query: 375 ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLP 434 A+ S+G ++ G +V++ + + + + + D+F R NP +L Sbjct: 307 ASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITRKPNP-----------HLG 355 Query: 435 FGAGPRSCIGEILARQELFLIMAWLLQRF 463 FG G C+G LAR EL ++ LL RF Sbjct: 356 FGQGVHYCLGANLARLELRVLFEELLSRF 384 >5IT1-A nrPDB Length = 399 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 49/204 (24%), Positives = 81/204 (39%), Gaps = 36/204 (17%) Query: 260 TNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLL 319 N D L+ A + +++ PD ++ D ++ G + A +TT ++ A LL Sbjct: 202 ANPGDDLISALITTED----PDG---VIDDMFLMNAAGTLLIAAHDTTACMIGLGTALLL 254 Query: 320 HNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDS 379 P DQ + P+ L+ + E+LR + A D Sbjct: 255 DRP----------DQLALLQKDPS--------LIGNAVEELLRYLTIGQFGAERVATQDG 296 Query: 380 SIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGP 439 IG + KG +V+ +L + + P++F R P +L FG G Sbjct: 297 EIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDITRRPAP-----------HLAFGFGA 345 Query: 440 RSCIGEILARQELFLIMAWLLQRF 463 CIG+ LAR EL ++ L +RF Sbjct: 346 HQCIGQQLARIELQIVFGTLFRRF 369 >6F0B-A nrPDB Length = 395 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 47/185 (25%), Positives = 78/185 (42%), Gaps = 30/185 (16%) Query: 279 GPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGF 338 GP Q+ +L I + I G G +TT S + +L P+ ++E + Sbjct: 211 GPYQEKQLTFHETIGVILMLIVG-GYDTTASTISLSLVSYALQPEKFSVVHEHPE----- 264 Query: 339 SRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWA 398 R+ LL + E+LR V+ + + A D +G V G V+ L Sbjct: 265 ----------RIPLL---VEELLRYHTVSQLGLGRIATEDVEVGGVTVRAGQMVVAALPL 311 Query: 399 LHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAW 458 + +E + PD+ +R PSV ++ FG GP C+G+ LAR EL + Sbjct: 312 ANRDESVFPNPDELDFDR-----------PSVPHVGFGYGPHQCVGQALARVELQEAIPA 360 Query: 459 LLQRF 463 +++R Sbjct: 361 VIRRL 365 >3SN5-A nrPDB Length = 491 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 45/196 (22%), Positives = 84/196 (42%), Gaps = 20/196 (10%) Query: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEID-------QNVGFSRTPTI---SDRNRLL 351 A T W+L ++ NP+ K EE+ Q V P ++ N L Sbjct: 268 ASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLP 327 Query: 352 LLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWA--LHHNEKEWHQP 409 +L++ I+E LRL + + K + + + + + + II L+ +H + + + P Sbjct: 328 VLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDP 387 Query: 410 DQFMPERFLNPAGTQLISPSVS-------YLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 F +R+L+ G + + Y+PFG+G C G + A E+ + +L Sbjct: 388 LTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSY 447 Query: 463 FDLE-VPDDGQLPSLE 477 F+LE + + P L+ Sbjct: 448 FELELIEGQAKCPPLD 463 >2X9P-A nrPDB Length = 404 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 51/191 (26%), Positives = 75/191 (39%), Gaps = 36/191 (18%) Query: 279 GPD-----QDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEID 333 GPD D EL D +G +F AG+++ S++ + L +P D Sbjct: 214 GPDIISRLNDGELTEDRVAHLAMGLLF-AGLDSVASIMDNGVVLLAAHP----------D 262 Query: 334 QNVGFSRTPTISDRNRLLLLEATIREVLRL-RPVAPMLIPHKANVDSSIGEFAVDKGTEV 392 Q P + R + EVLR R +L P A+ D G + G V Sbjct: 263 QRAAALADPDVMAR--------AVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLV 314 Query: 393 IINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQEL 452 + +L + +E+ + P++F R NP +L FG G CIG LAR EL Sbjct: 315 LFDLGLPNFDERAFTGPEEFDAARTPNP-----------HLTFGHGIWHCIGAPLARLEL 363 Query: 453 FLIMAWLLQRF 463 + L R Sbjct: 364 RTMFTKLFTRL 374 >2Z36-A nrPDB Length = 413 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 43/165 (26%), Positives = 71/165 (43%), Gaps = 29/165 (17%) Query: 299 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIR 358 + AG ETT +++ + LL +P+ + N G RTP + Sbjct: 242 LLTAGHETTANMISLGVVGLLSHPE----QLTVVKANPG--RTPM------------AVE 283 Query: 359 EVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418 E+LR +A + A D IG ++ G VI+++ + + W P F Sbjct: 284 ELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSAN-----WD------PAVFK 332 Query: 419 NPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 +PA + + +L FG GP C+G+ LAR EL ++ L +R Sbjct: 333 DPAVLDVERGARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRI 377 >3P3Z-A nrPDB Length = 416 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 43/179 (24%), Positives = 69/179 (38%), Gaps = 28/179 (15%) Query: 286 LLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTIS 345 +L D + T + + AG ETT + + +P DQ + P ++ Sbjct: 237 VLDDYELRTLVATVLVAGYETTNHQLALAMYDFAQHP----------DQWMKIKENPELA 286 Query: 346 DRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKE 405 + + EVLR P P+ A D + + GT V + H + + Sbjct: 287 PQ--------AVEEVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRV 338 Query: 406 WHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFD 464 + D+F + +PS++ FG GP C+G LAR EL +A L R D Sbjct: 339 FADADRF-------DITVKREAPSIA---FGGGPHFCLGTALARLELTEAVAALATRLD 387 >1GWI-A nrPDB Length = 411 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 61/238 (25%), Positives = 96/238 (40%), Gaps = 59/238 (24%) Query: 243 LNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGA 302 L I+ + R+ ++ L+QA N D+ L+D I++T+ + A Sbjct: 194 LASIMTDTVAAKRAAPGDDLTSALIQASENGDH-----------LTDAEIVSTLQLMVAA 242 Query: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLE------AT 356 G ETT S++ + L +P+ R L+L A Sbjct: 243 GHETTISLIVNAVVNLSTHPE------------------------QRALVLSGEAEWSAV 278 Query: 357 IREVLRLR-PVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQP--DQFM 413 + E LR P + +LI A D +G+ + G +I++ AL +E+ H P D+F Sbjct: 279 VEETLRFSTPTSHVLIRFAAE-DVPVGDRVIPAGDALIVSYGALGRDERA-HGPTADRF- 335 Query: 414 PERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF---DLEVP 468 +G + IS FG GP C G L+R E + + L RF DL VP Sbjct: 336 --DLTRTSGNRHIS-------FGHGPHVCPGAALSRMEAGVALPALYARFPHLDLAVP 384 >5Y1I-A nrPDB Length = 403 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 50/198 (25%), Positives = 81/198 (40%), Gaps = 43/198 (21%) Query: 281 DQDSELLSDNHILTTIGDI------------FGAGVETTTSVVKWTLAFLLHNPQVKKKL 328 D+ ++LSD + G+I GAG ETT +++ LL NP+ ++ Sbjct: 204 DRGDDILSDLAVQVEAGEITQDDAAGIGMMLLGAGHETTANMIALGTLALLENPEQLAEV 263 Query: 329 YEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDK 388 + D V + T+ E+LR +A + A D IG + Sbjct: 264 RDSDDPKV----------------IVNTVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKA 307 Query: 389 GTEVIINLWALHHNEKEWHQPDQF--MPERF-LNPAGTQLISPSVSYLPFGAGPRSCIGE 445 G ++ L N W PD + P+R ++ A + +L FG G C+G Sbjct: 308 GEGIVFPL-----NAANW-DPDLYPEAPDRLDIHRANAR------RHLAFGYGVHQCLGA 355 Query: 446 ILARQELFLIMAWLLQRF 463 LAR EL ++ + LL+R Sbjct: 356 TLARVELQIVYSTLLRRI 373 >3WVS-A nrPDB Length = 401 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 46/178 (25%), Positives = 73/178 (41%), Gaps = 30/178 (16%) Query: 287 LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD 346 L++ +L + AG ETT S + + LL PQ K+L ++ + Sbjct: 226 LTEQELLDHCIGLLIAGHETTASQIPSFVYALLDQPQHWKRLLDDPE------------- 272 Query: 347 RNRLLLLEATIREVLRLRPVAP-MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKE 405 L+ + + E+ R P+ P A D +G V G V++ L A + + Sbjct: 273 -----LIPSAVEELFRFVPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVALGAANRDGL- 326 Query: 406 WHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 RF +P +L PS ++ FG G C+G LAR EL + LL+R Sbjct: 327 ----------RFEDPEEIKLDRPSNHHIGFGHGIHHCLGAPLARLELQEALRALLERL 374 >1F4U-A nrPDB Length = 368 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 40/145 (27%), Positives = 71/145 (48%), Gaps = 16/145 (11%) Query: 347 RNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW 406 R L L+A I E LR P M K +G+ +++G V + + + + +E+ + Sbjct: 235 REENLYLKA-IEEALRYSPPV-MRTVRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVF 292 Query: 407 HQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF-DL 465 H ++F+P+R NP +L FG+G C+G LAR E + + +RF + Sbjct: 293 HDGEKFIPDRNPNP-----------HLSFGSGIHLCLGAPLARLEARIAIEEFSKRFRHI 341 Query: 466 EVPDDGQLPS--LEGIPKVVFLIDS 488 E+ D ++P+ L G ++V + S Sbjct: 342 EILDTEKVPNEVLNGYKRLVVRLKS 366 >2ZQJ-A nrPDB Length = 417 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 35/146 (23%), Positives = 62/146 (42%), Gaps = 13/146 (8%) Query: 354 EATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFM 413 E ++EV R P P L D KGT V+++L+ +H+ + W PD+F Sbjct: 277 EMFVQEVRRYYPFGPFLGA-LVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFR 335 Query: 414 PERFLNPAGTQLISPSVSYLPFGAG----PRSCIGEILARQELFLIMAWLLQRFDLEVPD 469 PERF +P G G C GE + + + + +L+ + + +VP+ Sbjct: 336 PERFAEREENLF-----DMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPE 390 Query: 470 DG---QLPSLEGIPKVVFLIDSFKVK 492 L + +P+ F++ + K Sbjct: 391 QSLHYSLARMPSLPESGFVMSGIRRK 416 >3AWQ-A nrPDB Length = 415 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 35/145 (24%), Positives = 63/145 (43%), Gaps = 13/145 (8%) Query: 354 EATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFM 413 E ++EV R P P ++ +A+ D A +G +V+++L+ +H+ W P +F Sbjct: 275 ELFVQEVRRFYPFFPAVVA-RASQDFEWEGMAFPEGRQVVLDLYGSNHDAATWADPQEFR 333 Query: 414 PERFLNPAGTQLISPSVSYLPFGAGP----RSCIGEILARQELFLIMAWLLQRFDLEVPD 469 PERF S +++P G G C GE + + + L+ +VPD Sbjct: 334 PERF-----RAWDEDSFNFIPQGGGDHYLGHRCPGEWIVLAIMKVAAHLLVNAMRYDVPD 388 Query: 470 DG---QLPSLEGIPKVVFLIDSFKV 491 L +PK F++ + + Sbjct: 389 QDLSIDFARLPALPKSGFVMRNVHI 413 >3TKT-A nrPDB Length = 450 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 35/121 (28%), Positives = 58/121 (47%), Gaps = 17/121 (14%) Query: 345 SDRNRLLLLEATIREVLR-LRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNE 403 +DRN LL + E +R PV + A D+ + + G +++N A +H+ Sbjct: 317 ADRN---LLPGIVEEAIRWTTPVQHFM--RTAATDTELCGQKIAAGDWLMLNYVAANHDP 371 Query: 404 KEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 ++ +P +F P R P+ +L FGAG C+G LAR E+ +++ LL R Sbjct: 372 AQFPEPRKFDPTR-----------PANRHLAFGAGSHQCLGLHLARLEMRVLLDVLLDRV 420 Query: 464 D 464 D Sbjct: 421 D 421 >2Y5N-A nrPDB Length = 417 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 45/213 (21%), Positives = 89/213 (41%), Gaps = 41/213 (19%) Query: 252 EKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVV 311 ++ R + +++ L+QA+ D+ LS+ +L + AG E+TT+ + Sbjct: 215 DRRRKEPTDDLVSALVQARDQQDS-----------LSEQELLDLAIGLLVAGYESTTTQI 263 Query: 312 KWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVA-PML 370 + L+ P+++++L +R L+ + + E+ R P+ Sbjct: 264 ADFVYLLMTRPELRRQLL------------------DRPELIPSAVEELTRWVPLGVGTA 305 Query: 371 IPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSV 430 P A D ++ + G V+ + A + ++ ++ D+ +R N Sbjct: 306 FPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDRTPN----------- 354 Query: 431 SYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 +L FG G C+G LAR EL + + LLQR Sbjct: 355 QHLGFGHGVHHCLGAPLARVELQVALEVLLQRL 387 >2RFC-A nrPDB Length = 343 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 44/164 (26%), Positives = 70/164 (42%), Gaps = 37/164 (22%) Query: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361 G ETTT+++ + + NP + ID + +NR +E T Sbjct: 188 GGNETTTNLIGNMIRVIDENPDI-------IDDAL----------KNRSGFVEET----- 225 Query: 362 RLRPVAPM-LIPHK-ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLN 419 LR +P+ +PH+ A DS I + KG +VI+ L + + +E + +PD F Sbjct: 226 -LRYYSPIQFLPHRFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFDEPDLFK------ 278 Query: 420 PAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 I +L FG G C+G LAR E + + +L F Sbjct: 279 ------IGRREMHLAFGIGIHMCLGAPLARLEASIALNDILNHF 316 >5FOI-A nrPDB Length = 408 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 39/164 (23%), Positives = 70/164 (42%), Gaps = 30/164 (18%) Query: 299 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIR 358 + AG ET+ + V ++ LL +P+ +L E+ + L+ + Sbjct: 244 LLAAGHETSANQVTLSVLTLLRHPETAAELREQPE------------------LMPNAVD 285 Query: 359 EVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418 E+LR +A L A D +G+ + G +II L + +H+ + F R Sbjct: 286 ELLRYHSIADGLR-RAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHR-- 342 Query: 419 NPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 P+ ++ FG GP C+G+ LAR E+ + + L +R Sbjct: 343 ---------PARHHVAFGYGPHQCLGQNLARLEMEVTLGKLFRR 377 >2WIY-A nrPDB Length = 394 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 36/131 (27%), Positives = 65/131 (49%), Gaps = 16/131 (12%) Query: 338 FSRTPTI--SDRNRLLLLEATIREVLRLRP--VAPMLIPHKANVDSSIGEFAVDKGTEVI 393 F+R P + + RN A I E++R+ P ++ + P + D IG ++ G+ + Sbjct: 249 FARRPEVFTAFRNDESARAAIINEMVRMDPPQLSFLRFPTE---DVEIGGVLIEAGSPIR 305 Query: 394 INLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELF 453 + A + + + + PD F R PA ++ +S FG GP SC G+I++R E Sbjct: 306 FMIGAANRDPEVFDDPDVFDHTR--PPAASRNLS-------FGLGPHSCAGQIISRAEAT 356 Query: 454 LIMAWLLQRFD 464 + A L +R++ Sbjct: 357 TVFAVLAERYE 367 >5OFQ-A nrPDB Length = 409 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 48/185 (25%), Positives = 77/185 (41%), Gaps = 40/185 (21%) Query: 283 DSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTP 342 D E L++ +L + AG ETTT+++ + ++ + V+ ++ Sbjct: 222 DGEHLTEEEVLGFCILLLVAGNETTTNLITNGVRYMTEDVDVQNEV-------------- 267 Query: 343 TISDRNRLLLLEATIREVLRLRPVAPM-LIPHKANVDSSIGEFAVDKGTEVIINLWALHH 401 R + L+ + E LR P P+ I A D +GE + +G +VI WA Sbjct: 268 ----RRDISLVPNLVEETLRYYP--PIQAIGRIAAEDVELGECKIKRGQQVI--SWAASA 319 Query: 402 NEK----EWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMA 457 N EW PD F+ R NP ++ FG G C+G LAR E + Sbjct: 320 NRDSAKFEW--PDTFVVHRKTNP-----------HVSFGFGIHFCLGAPLARMEGKIAFT 366 Query: 458 WLLQR 462 LL++ Sbjct: 367 KLLEK 371 >4GGV-A nrPDB Length = 418 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 72/321 (22%), Positives = 130/321 (40%), Gaps = 59/321 (18%) Query: 164 SIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKI 223 + D+++P+ V V I GD +L + + + II+ S S +D + Sbjct: 146 AADLAYPLPVIV------IAELLGVPAGDRDL--FKKWADDIIEGFSGFSFLDTSGQGEQ 197 Query: 224 FPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQD 283 E+L+ LL+ + + E+ R+ ++L L+QA++ D Sbjct: 198 DVRDATERLRP-------LLDYMAGHVTERRRTPR-EDLLTHLVQAEV-----------D 238 Query: 284 SELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPT 343 E L+DN I+ + G TTT + T+ L +P+V K+ Sbjct: 239 GERLTDNEIVNVANILLVTGHITTTMTLGNTVLCLDADPEVAAKVR-------------- 284 Query: 344 ISDRNRLLLLEATIREVLR-LRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHN 402 +DR+ L+ I E LR L P A + + + + + K V++ L A + + Sbjct: 285 -ADRS---LVPGAIEEALRVLSPSAALA--RGTSREVEVAGTVIPKDQIVMLWLGAGNRD 338 Query: 403 EKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 +++ P+ + P R NP + FG G C+G LAR E + + L R Sbjct: 339 PRQFTDPEVYDPTRDPNP-----------HFGFGRGIHFCLGAPLARLEGRVALNALFDR 387 Query: 463 FDLEVPDDGQLPSLEGIPKVV 483 F + D + P+ P ++ Sbjct: 388 FPVLRTDPAKPPTFFPTPDMI 408 >3ABA-A nrPDB Length = 403 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 49/233 (21%), Positives = 88/233 (37%), Gaps = 38/233 (16%) Query: 240 NDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLS---------DN 290 D+ ++ ++ +++ L L+ + N G D S L++ D Sbjct: 166 QDIAEAMMRVDQDAAATEAAGMRLGGLLYQLVQERRANPGDDLISALITTEDPDGVVDDM 225 Query: 291 HILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRL 350 ++ G + A +TT ++ A LL +P DQ P+ Sbjct: 226 FLMNAAGTLLIAAHDTTACMIGLGTALLLDSP----------DQLALLREDPS------- 268 Query: 351 LLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPD 410 L+ + E+LR + A D +G + KG +V+ ++ A + +P+ Sbjct: 269 -LVGNAVEELLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPE 327 Query: 411 QFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 +F R P +L FG G CIG+ LAR EL ++ L +R Sbjct: 328 RFDITRRPAP-----------HLAFGFGAHQCIGQQLARIELQIVFETLFRRL 369 >3MGX-A nrPDB Length = 415 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 35/117 (29%), Positives = 53/117 (45%), Gaps = 15/117 (12%) Query: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412 ++ + EVLR A M + D +I + GT V+ L A + + E+ PD F Sbjct: 287 VDTVVEEVLRWTSPA-MHVLRVTTADVTINGRDLPSGTPVVAWLPAANRDPAEFDDPDTF 345 Query: 413 MPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWL---LQRFDLE 466 +P R N ++ FG G C+G LAR EL +++ L + R DLE Sbjct: 346 LPGRKPN-----------RHITFGHGMHHCLGSALARIELSVVLRVLAERVSRVDLE 391 >2XKR-A nrPDB Length = 398 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 63/213 (29%), Positives = 89/213 (41%), Gaps = 43/213 (20%) Query: 283 DSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTP 342 D E LSD+ ++ I G ETT + LL N DQ R P Sbjct: 211 DGERLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNR----------DQWDLLQRDP 260 Query: 343 TISDRNRLLLLEATIREVLR-LRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHH 401 + LL I E+LR PV M D+ A+ G ++++ + + Sbjct: 261 S--------LLPGAIEEMLRWTAPVKNMC--RVLTADTEFHGTALCAGEKMMLLFESANF 310 Query: 402 NEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQ 461 +E + +P++F +R NP S+L FG G C+G LAR EL L+ +L+ Sbjct: 311 DEAVFCEPEKFDVQR--NPN---------SHLAFGFGTHFCLGNQLARLELSLMTERVLR 359 Query: 462 RF-DLE-VPDDGQLP--------SLEGIPKVVF 484 R DL V DD LP LE +P VVF Sbjct: 360 RLPDLRLVADDSVLPLRPANFVSGLESMP-VVF 391 >4MM0-A nrPDB Length = 399 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 61/285 (21%), Positives = 112/285 (39%), Gaps = 51/285 (17%) Query: 198 IQNYNEGIIDNLSKDSL-VDLVPWLKI------------FPNKTLEKLKSHVKIRNDLLN 244 ++ EG++D + K D+V L + P + + + L Sbjct: 116 LEEIAEGLLDEMEKKGAPADIVESLAVPFPITVICELLGVPMVDVARFRGWADTMVSLTG 175 Query: 245 KILENYKEKFRSDSITNMLDTLMQAKMNSDNGN------AGPDQDSELLSDNHILTTIGD 298 +E++ D++ + LD L+ AK + + A +D+EL +D+ + + Sbjct: 176 YSMEDWTAA--RDALESYLDGLVAAKRENPGSDLLSALVATAAEDNEL-TDHDVRSLSLI 232 Query: 299 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIR 358 + AG E ++ + ++ LL P D+ R P LL + + Sbjct: 233 LLLAGYEPASNQLGSSVLTLLRFP----------DRLAELRRDPG--------LLPSAVE 274 Query: 359 EVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418 E++R P + D +IG+ + + V+ + A + W P RF Sbjct: 275 ELMRYAPAGDGALFRVTLEDVTIGDTHIPANSAVLASTQAAN-----WD------PRRFD 323 Query: 419 NPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 +P G +L P + G G C+G LAR EL + + LL+RF Sbjct: 324 DPTGLRLDRPDNQHTALGHGIHFCLGAALARVELQVAIGALLRRF 368 >5HIW-A nrPDB Length = 398 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 30/104 (28%), Positives = 50/104 (48%), Gaps = 11/104 (10%) Query: 378 DSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGA 437 +++IG + GT + ++L A H++E+ + +P+ F R P G L FG Sbjct: 285 EATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDIHR--RPVG---------MLNFGG 333 Query: 438 GPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPK 481 G C+G LAR E + ++ LL+RF D P+ P+ Sbjct: 334 GLHYCVGAPLARMEARVGVSLLLERFPALRADPTVQPTFSTAPR 377 >4TRI-A nrPDB Length = 407 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 62/251 (24%), Positives = 99/251 (39%), Gaps = 48/251 (19%) Query: 232 LKSHVKIRNDLLNKILENYKE--KFRSDSITNM----LDTLMQAKMNSDNGNAGPDQDSE 285 L SHV + K+++ + +F D IT D L +NS+ + + Sbjct: 166 LSSHVD--EAAIQKLMDTFAAYTEFTKDVITKRRAEPTDDLFSVLVNSE-------VEGQ 216 Query: 286 LLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTIS 345 +SD+ I+ I G ETT + LL + L ++D Sbjct: 217 RMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVD------------ 264 Query: 346 DRNRLLLLEATIREVLR-LRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEK 404 LL I E+LR PV M D+ + G ++++ + + +E Sbjct: 265 ------LLPGAIEEMLRWTSPVKNMC--RTLTADTVFHGTELRAGEKIMLMFESANFDES 316 Query: 405 EWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF- 463 + PD F +R NP S++ FG G C+G LAR EL L+ +L+R Sbjct: 317 VFGDPDNFRIDR--NPN---------SHVAFGFGTHFCLGNQLARLELRLMTERVLRRLP 365 Query: 464 DLEVPDDGQLP 474 DL + DD +P Sbjct: 366 DLRLADDAPVP 376 >3EJB-B nrPDB Length = 404 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 44/161 (27%), Positives = 65/161 (40%), Gaps = 30/161 (18%) Query: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361 AG ETT +++ ++ LL +P+ KL E D L+ + E L Sbjct: 234 AGHETTVNLISNSVLCLLQHPEQLLKLRENPD------------------LIGTAVEECL 275 Query: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA 421 R M A+ D I + +G +V + L A + + + PD F R NP Sbjct: 276 RYESPTQM-TARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP- 333 Query: 422 GTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 +L FG G C+G LAR E + + LLQR Sbjct: 334 ----------HLSFGHGHHVCLGSSLARLEAQIAINTLLQR 364 >4WPZ-A nrPDB Length = 397 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 53/187 (28%), Positives = 79/187 (42%), Gaps = 35/187 (18%) Query: 281 DQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSR 340 D DS L I +IG I AG ETT + + L LLHNP+ KL + Sbjct: 212 DGDSTLTEREIIALSIG-ILSAGHETTANQISMFLVTLLHNPEELDKLRD---------- 260 Query: 341 TPTISDRNRLLLLEATIREVLRLRPVAPM--LIPH--KANVDSSIGEFAVDKGTEVIINL 396 NR + +A + E+LR P+ +IP A V+ S G+ + G V+ + Sbjct: 261 -------NREAIPKA-VDELLRFVPLTTTGGIIPRLTTAEVELSGGQV-LPAGAVVLPAV 311 Query: 397 WALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIM 456 + + + + ++ R NP +L FGAG C+G LAR EL + Sbjct: 312 ATANRDPEVFEDGERLNVTRENNP-----------HLAFGAGIHHCLGAQLARIELQEAL 360 Query: 457 AWLLQRF 463 +L R Sbjct: 361 GAILDRM 367 >5FYF-A nrPDB Length = 470 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 30/114 (26%), Positives = 58/114 (50%), Gaps = 13/114 (11%) Query: 352 LLEATIREVLRLR-PVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPD 410 L+ + E++R + P+A M A D +G + KG V++ + + +E+++ PD Sbjct: 339 LIPNMVSEIIRWQTPLAYMR--RIAKQDVELGGQTIKKGDRVVMWYASGNRDERKFDNPD 396 Query: 411 QFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFD 464 QF+ +R + +++ FG G C+G LA +L ++ +L+RFD Sbjct: 397 QFIIDR----------KDARNHMSFGYGVHRCMGNRLAELQLRILWEEILKRFD 440 >1Q5D-A nrPDB Length = 419 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 64/295 (21%), Positives = 113/295 (38%), Gaps = 65/295 (22%) Query: 189 KNGDPELNVIQNYNEGIIDNLSKDSLVDLVPW-----LKIFPNKTLEKLKSHVKIRND-- 241 ++G E +V+++Y EGI + S + VP + F + T L + R D Sbjct: 137 RSGQEEFDVVRDYAEGI--PMRAISALLKVPAECDEKFRRFGSATARALGVGLVPRVDEE 194 Query: 242 -------------LLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLS 288 LL+ +L+ E+ R+ ++L L+QA + D LS Sbjct: 195 TKTLVASVTEGLALLHGVLD---ERRRNPLENDVLTMLLQA-----------EADGSRLS 240 Query: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348 ++ +G I AG +TT ++ + + LL +P+ E + G R Sbjct: 241 TKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEA----LELVKAEPGLMRN------- 289 Query: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408 + EVLR + + A D ++ KG V + + + + + + Sbjct: 290 -------ALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIPSALRDGTVFSR 342 Query: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 PD F R + + L +G GP C G LAR E + + + +RF Sbjct: 343 PDVFDVRR-----------DTSASLAYGRGPHVCPGVSLARLEAEIAVGTIFRRF 386 >1EHE-A nrPDB Length = 403 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 32/112 (28%), Positives = 50/112 (44%), Gaps = 10/112 (8%) Query: 357 IREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPER 416 + E+ R + + I A D IG+ V +I + + + +E+ + PD+F R Sbjct: 276 VEELCRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNR 335 Query: 417 FLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF-DLEV 467 P L FG G CI E LA+ EL + + L Q+F DL+V Sbjct: 336 KWPPQDP---------LGFGFGDHRCIAEHLAKAELTTVFSTLYQKFPDLKV 378 >1ODO-A nrPDB Length = 408 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 62/266 (23%), Positives = 105/266 (39%), Gaps = 44/266 (16%) Query: 240 NDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGN-------AGPDQ-DSELLSDNH 291 + + + L+ + + + + +LD L+ AK + + A D+ D + LS Sbjct: 172 DGVFDTTLDQAEAQANTARLYEVLDQLIAAKRATPGDDMTSLLIAARDDEGDGDRLSPEE 231 Query: 292 ILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLL 351 + T+ + AG ETT +V+ + LL P DQ + R ++ + Sbjct: 232 LRDTLLLMISAGYETTVNVIDQAVHTLLTRP----------DQ-LALVRKGEVTWAD--- 277 Query: 352 LLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ-PD 410 + E LR P L A D ++ + E I+ +A + +WH+ D Sbjct: 278 ----VVEETLRHEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDAD 333 Query: 411 QFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF-DLEVPD 469 F R + +L FG G C+G LAR E+ L + L RF DL + D Sbjct: 334 TFDATRTVK-----------EHLAFGHGVHFCLGAPLARMEVTLALESLFGRFPDLRLAD 382 Query: 470 DGQLPSLEGIPKVVFLIDSFKVKIKV 495 E +P V LI + ++ V Sbjct: 383 PA-----EELPPVPSLISNGHQRLPV 403 >6M7L-A nrPDB Length = 404 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 48/204 (23%), Positives = 74/204 (36%), Gaps = 42/204 (20%) Query: 267 MQAKMNSDNGNA-----GPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHN 321 + A++ D G+ D +++ SD + + + VE T S + LL + Sbjct: 205 LAARLRRDPGDGMLGMVARDHGADI-SDEELAGLCAVVMNSSVEQTESCLAAGTLLLLEH 263 Query: 322 PQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSI 381 P+ L R R L E + E++R V L P A D I Sbjct: 264 PEQFALL------------------RERPELGEQAVEEIVRYLSVFEGLDPRTATEDVEI 305 Query: 382 GEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA--GTQLISPSVSYLPFGAGP 439 G + KG V +L A + +PA G + ++ FG G Sbjct: 306 GGQVIKKGEAVFCSLLAANRA----------------DPALDGFDITRKESRHVAFGHGI 349 Query: 440 RSCIGEILARQELFLIMAWLLQRF 463 C+G LAR EL + L+ RF Sbjct: 350 HHCLGAPLARMELRIAFTTLVSRF 373 >4YZR-A nrPDB Length = 405 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 61/280 (21%), Positives = 113/280 (40%), Gaps = 63/280 (22%) Query: 212 DSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKM 271 +++VD + N+ L + K D + K++ + + K + D I+ ++ Sbjct: 173 NAMVDTSEGNRELTNQALREFK-------DYIAKLIHDRRIKPKDDLISKLVHA------ 219 Query: 272 NSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVV-KWTLAFLLHNPQVKKKLYE 330 +NG+ LS+ + + + + AG+ETT +++ TLA L H + +K Sbjct: 220 -EENGSK--------LSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEK---- 266 Query: 331 EIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGT 390 + P ++ + E+LR M+ A D + ++ +G Sbjct: 267 -------LKQQPE--------MIATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGD 311 Query: 391 EVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQ 450 + I + + + + P F NP + ++ FG G C+G LAR Sbjct: 312 MIFIGIGSANRD-----------PNFFENPEILNINRSPNRHISFGFGIHFCLGAPLARL 360 Query: 451 ELFLIMAWLLQRF-DLEV---PDDGQ------LPSLEGIP 480 E + LL+RF D+E+ PDD Q L LE +P Sbjct: 361 EGHIAFKALLKRFPDIELAVAPDDIQWRKNVFLRGLESLP 400 >2VZM-A nrPDB Length = 436 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 47/192 (24%), Positives = 74/192 (38%), Gaps = 49/192 (25%) Query: 281 DQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSR 340 D+D L+ +L + AG ETT +++ + LL +P DQ Sbjct: 242 DEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHP----------DQLAAL-- 289 Query: 341 TPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVD----------KGT 390 R + LL+ + E+LR ++ V+S+ F V+ G Sbjct: 290 ------RADMTLLDGAVEEMLR----------YEGPVESATYRFPVEPVDLDGTVIPAGD 333 Query: 391 EVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQ 450 V++ L H PERF +P + + +L FG G CIG LAR Sbjct: 334 TVLVVLADAHRT-----------PERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARL 382 Query: 451 ELFLIMAWLLQR 462 E + + LL+R Sbjct: 383 EARIAVRALLER 394 >3RWL-A nrPDB Length = 426 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 31/113 (27%), Positives = 59/113 (52%), Gaps = 13/113 (11%) Query: 352 LLEATIREVLRLR-PVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPD 410 L+E + E++R + P+A M A DS +G + KG +V++ ++ + +++ +P+ Sbjct: 297 LVETMVPEIIRWQTPLAHMR--RTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPE 354 Query: 411 QFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 +F+ +R P Q +L FG G C+G LA +L ++ +L RF Sbjct: 355 EFIIDR---PRPRQ-------HLSFGFGIHRCVGNRLAEMQLRILWEEILTRF 397 >1UE8-A nrPDB Length = 367 Score = 41.6 bits (96), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 52/109 (47%), Gaps = 14/109 (12%) Query: 356 TIREVLRLRPVAPMLIPHKANVDS-SIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMP 414 + E LR P P++ + + I + +D+G V + + + + +E+ + PD F+P Sbjct: 243 AVEEALRFSP--PVMRTIRVTKEKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSFIP 300 Query: 415 ERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 +R NP +L FG+G C+G LAR E + + ++F Sbjct: 301 DRTPNP-----------HLSFGSGIHLCLGAPLARLEARIALEEFAKKF 338 >5XW2-A nrPDB Length = 419 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 53/225 (23%), Positives = 96/225 (42%), Gaps = 46/225 (20%) Query: 243 LNKILENYKE---KFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDI 299 + K+LE +E + R +++ L++A++ D L+DNHI+ + Sbjct: 205 MRKMLEYLREHAAECRRRPRGDLMGKLIEAEV-----------DGRRLTDNHIVNFAKML 253 Query: 300 FGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIRE 359 AG TTT ++ T+ L P+ ++ +DR+ L+ + E Sbjct: 254 LIAGYLTTTMLIGNTVLCLDSYPEQAARVR---------------ADRS---LIPGLLEE 295 Query: 360 VLR-LRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418 +R L PVA +V+ + + D+ V++ A + + +++ +P+ F R Sbjct: 296 SMRFLSPVAATYRATTRDVEVAGQRLSADQ--MVMVWFGAANRDARQFAEPELFDMTRGP 353 Query: 419 NPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 NP +L FG G C+G LAR E + + LL RF Sbjct: 354 NP-----------HLGFGRGIHFCLGGPLARMEGRVALDHLLDRF 387 >2WIO-A nrPDB Length = 431 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/113 (30%), Positives = 49/113 (43%), Gaps = 14/113 (12%) Query: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHN-EKEWHQ-PD 410 + A + EVLR RP P + G V +V++N W L N + + H PD Sbjct: 294 IPAIVEEVLRYRPPFPQMQRTTTKATEVAG---VPIPADVMVNTWVLSANRDSDAHDDPD 350 Query: 411 QFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 +F P R S + L FG G C+G LAR E + + ++ RF Sbjct: 351 RFDPSR---------KSGGAAQLSFGHGVHFCLGAPLARLENRVALEEIIARF 394 >3ABB-A nrPDB Length = 408 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 38/162 (23%), Positives = 66/162 (40%), Gaps = 30/162 (18%) Query: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361 AG ETT + + L+ +P E+ID R P + + E+L Sbjct: 243 AGHETTVNAIALGALTLIQHP-------EQIDV---LLRDPGA--------VSGVVEELL 284 Query: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA 421 R V+ ++ A D +G + G V++++ ++ + K + PD F R Sbjct: 285 RFTSVSDHIV-RMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFDARRN---- 339 Query: 422 GTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 + ++ FG G C+G+ LAR EL + + L R Sbjct: 340 -------ARHHVGFGHGIHQCLGQNLARAELEIALGGLFARI 374 >3BUJ-A nrPDB Length = 397 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 46/170 (27%), Positives = 69/170 (40%), Gaps = 30/170 (17%) Query: 282 QDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRT 341 D L+S N I++T+ G ET S V + LL +P L Sbjct: 213 HDRGLMSRNEIVSTVVTFIFTGHETVASQVGNAVLSLLAHPDQLDLL------------- 259 Query: 342 PTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHH 401 R R LL + E LR P + +VD + + + V++ A + Sbjct: 260 -----RRRPDLLAQAVEECLRYDPSVQSNT-RQLDVDVELRGRRLRRDDVVVVLAGAANR 313 Query: 402 NEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQE 451 + + + +PD F ER +P PS+S FGAG R C+G LAR + Sbjct: 314 DPRRYDRPDDFDIER--DPV------PSMS---FGAGMRYCLGSYLARTQ 352 >6GMF-A nrPDB Length = 397 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 46/181 (25%), Positives = 72/181 (39%), Gaps = 30/181 (16%) Query: 283 DSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTP 342 D E L+ +L+ + AG ETTTS++ L L +P+ + Sbjct: 214 DGEKLTAGEVLSFANTLLIAGNETTTSLIGNALVALTDHPEQLAAAQAD----------- 262 Query: 343 TISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHN 402 L L+ A + EVLR A I + D IG+ + + V+ L + + + Sbjct: 263 -------LSLVPAVVEEVLRYESPA-QCIFRQTMTDVEIGDERIPARSVVLPLLASANRD 314 Query: 403 EKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 E + PD+F R + +L FG CIG LAR E +++ LL R Sbjct: 315 ESRFPDPDRFDIHR-----------DTKGHLAFGLDIHFCIGAPLARLEAKVMLEVLLAR 363 Query: 463 F 463 Sbjct: 364 L 364 >5XJN-A nrPDB Length = 455 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 39/168 (23%), Positives = 76/168 (45%), Gaps = 29/168 (17%) Query: 282 QDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRT 341 Q+ + ++D+ I + + + AG ETTT+++ LL +P+ + + E Sbjct: 272 QEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILE----------N 321 Query: 342 PTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHH 401 P L+ A + EVLR + + KA D+ IG A+ +G V++ + + + Sbjct: 322 PK--------LIPAAVDEVLRYSG-SIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANR 372 Query: 402 NEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILAR 449 +E + ++F R + + +L FG G C+G +LA+ Sbjct: 373 DEARFENGEEFDISR----------ANAREHLSFGFGIHYCLGNMLAK 410 >5GWE-A nrPDB Length = 405 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 39/168 (23%), Positives = 76/168 (45%), Gaps = 29/168 (17%) Query: 282 QDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRT 341 Q+ + ++D+ I + + + AG ETTT+++ LL +P+ + + E Sbjct: 222 QEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILE----------N 271 Query: 342 PTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHH 401 P L+ A + EVLR + + KA D+ IG A+ +G V++ + + + Sbjct: 272 PK--------LIPAAVDEVLRYSG-SIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANR 322 Query: 402 NEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILAR 449 +E + ++F R + + +L FG G C+G +LA+ Sbjct: 323 DEARFENGEEFDISR----------ANAREHLSFGFGIHYCLGNMLAK 360 >2ZBZ-A nrPDB Length = 412 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 53/230 (23%), Positives = 92/230 (40%), Gaps = 41/230 (17%) Query: 233 KSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292 +S + RNDL L+ +F+++ ++ L+ ++ A + D E L + Sbjct: 187 QSALTARNDLAG-YLDGLITQFQTEPGAGLVGALVADQL------ANGEIDREELISTAM 239 Query: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352 L I AG ETT S+ ++ LL +P+ L +DR+ L Sbjct: 240 LLLI-----AGHETTASMTSLSVITLLDHPEQYAALR---------------ADRS---L 276 Query: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412 + + E+LR +A + A D + + G VI+ + + + PD Sbjct: 277 VPGAVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTVYEDPDAL 336 Query: 413 MPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 R + +L FG G C+G+ LAR EL +I+ L+ R Sbjct: 337 DIHR-----------SARHHLAFGFGVHQCLGQNLARLELEVILNALMDR 375 >6G71-A nrPDB Length = 405 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 23/91 (25%), Positives = 46/91 (50%), Gaps = 12/91 (13%) Query: 363 LRPVAPM-LIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA 421 +R VAP+ ++P + VD+ + + + +G ++ + + + + + W PD+F ER Sbjct: 277 IRWVAPIGMVPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRFDIER----- 331 Query: 422 GTQLISPSVSYLPFGAGPRSCIGEILARQEL 452 S ++L FG G C+G AR ++ Sbjct: 332 ------GSEAHLAFGKGVHVCLGAWAARSQV 356 >5YSW-A nrPDB Length = 441 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 50/213 (23%), Positives = 81/213 (38%), Gaps = 39/213 (18%) Query: 260 TNMLDTLMQAKMNSDNGNAGPDQDSEL---------LSDNHILTTIGDIFGAGVETTTSV 310 + L MQA + N D S L L+D+ ++ + AG +TT S+ Sbjct: 226 ADALRAFMQALVTDKRANPAGDIISGLIHHAGADPALTDDELINIANLLLIAGYDTTASM 285 Query: 311 VKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPML 370 + + LL P L ++ + I+D + E+LR V Sbjct: 286 LGLGIFVLLQRPAQLATLRDDPSR---------IAD---------AVEELLRYLSVVNPG 327 Query: 371 IPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSV 430 I A D + G+ V++++ A + + + W PD L P Sbjct: 328 IFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDPD------------LDLTRPRG 375 Query: 431 SYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 +L FG G C+G+ LAR E+ A LL+R Sbjct: 376 PHLAFGHGVHQCLGQQLARMEMQAGYAELLRRL 408 >3B98-A nrPDB Length = 475 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 42/173 (24%), Positives = 72/173 (41%), Gaps = 24/173 (13%) Query: 313 WTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIP 372 W + +LL +P+ + + EEI G + + ++ + E LRL A LI Sbjct: 275 WVMGYLLTHPEALRAVREEIQ---GGKHLRLEERQKNTPVFDSVLWETLRL--TAAALIT 329 Query: 373 HKANVDSSIG-----EFAVDKGTEVIINLWALHHNEKEWHQ-PDQFMPERFLNP------ 420 D I E+ + +G + + + + + HQ P+ F +RFLN Sbjct: 330 RDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKK 389 Query: 421 ----AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPD 469 G ++ PSV P+G C G A + ++ +L RFD+E+ D Sbjct: 390 DFFKNGARVKYPSV---PWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCD 439 >4Z5Q-A nrPDB Length = 423 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 48/211 (22%), Positives = 88/211 (41%), Gaps = 41/211 (19%) Query: 243 LNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGA 302 L K E+ ++ R++ ++ L++A+ D L++ ++ I Sbjct: 215 LQKYFEDLVKERRAEPRDDLTSALIEARDAHDR-----------LAEPELIGLCISILIG 263 Query: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLR 362 G ETT S ++ +H Q +++L+ T +D + A + E+LR Sbjct: 264 GFETTAS----EISSFVHVLQQRRELW-----------TRLCADPE---AIPAAVEELLR 305 Query: 363 LRPVAPMLI-PHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA 421 P A I P A D ++G V +G VI++ A++ + + D+ + +R N Sbjct: 306 FVPFAANGISPRYALEDMTVGGVLVREGEPVIVDTSAVNRDGLVFDNADEVVIDRADN-- 363 Query: 422 GTQLISPSVSYLPFGAGPRSCIGEILARQEL 452 ++ FG G C+G LAR EL Sbjct: 364 ---------RHMVFGHGAHHCLGAHLARVEL 385 >5NWS-A nrPDB Length = 435 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 54/241 (22%), Positives = 95/241 (39%), Gaps = 40/241 (16%) Query: 230 EKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSD 289 E+L+ + D ++++E + D +L L++A+ D D LSD Sbjct: 209 ERLRHSFPVMIDYCHRLIEQRRAALTDD----LLSELIRAQ----------DDDGGRLSD 254 Query: 290 NHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNR 349 +T I + AG ET+ ++ A LL +P L R Sbjct: 255 IETVTMILTLVLAGHETSAHLIGNGTAALLTHPGQWALL------------------RKD 296 Query: 350 LLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQP 409 LL + E++R + A D + V +G V + L + + + + + P Sbjct: 297 PALLPRAVHELMRWCGSVHVARLRYATEDLELAGTPVARGDAVQLVLVSANFDPRHYSDP 356 Query: 410 DQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF-DLEVP 468 D+ R + +++ FG G C+G LARQE + +A LL+ + DL + Sbjct: 357 DRLDITRHQE-------GQAENHVGFGHGIHYCLGATLARQEGEVALARLLETYPDLALA 409 Query: 469 D 469 D Sbjct: 410 D 410 >5YHJ-A nrPDB Length = 413 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 27/116 (23%), Positives = 51/116 (43%), Gaps = 10/116 (8%) Query: 357 IREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPER 416 ++EV R P P+ + D +A +GT +++L+ +H+ W +PD+F P R Sbjct: 276 VQEVRRFYPFFPVAAA-RVKTDFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSR 334 Query: 417 FLNPAGTQLISPSVSYLPFGAGP----RSCIGEILARQELFLIMAWLLQRFDLEVP 468 F + + +++P G G C GE + L ++ + + VP Sbjct: 335 FKDWKESPF-----NFIPQGGGDVDFGHRCAGEHVTIAILAQVIELFTKEYAYTVP 385 >4XE3-A nrPDB Length = 407 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 46/184 (25%), Positives = 74/184 (40%), Gaps = 33/184 (17%) Query: 286 LLSDNHILTTIGDIFGAGVET-----TTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSR 340 L +DN T G+I GV TSV + T L+H ++K YE + + Sbjct: 221 LATDNDDHLTKGEIVNMGVSLLIAGHETSVNQIT--NLVHLLLTERKRYESLVADPA--- 275 Query: 341 TPTISDRNRLLLLEATIREVLRLRP-VAPMLIPHKANVDSSIGEFAVDKGTEVIINLWAL 399 L+ A + E+LR P V+ A D + V G +++ + Sbjct: 276 -----------LVPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASA 324 Query: 400 HHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWL 459 + +E+ + D+ R NP ++ FG G CIG L R EL ++ L Sbjct: 325 NRDEEVFDHADELDFHRERNP-----------HIAFGHGAHHCIGAQLGRLELQEALSAL 373 Query: 460 LQRF 463 ++RF Sbjct: 374 VRRF 377 >1UED-A nrPDB Length = 406 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 55/223 (24%), Positives = 91/223 (40%), Gaps = 46/223 (20%) Query: 243 LNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGA 302 N+ L+N + R+D +L +++ D+G+ D++ + L IL Sbjct: 199 FNRYLDNLLARQRADPDDGLLGMIVR-----DHGDNVTDEELKGLCTALIL--------G 245 Query: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLR 362 GVET ++ + + LL NP + L+E +P ++R + E++R Sbjct: 246 GVETVAGMIGFGVLALLDNPGQIELLFE----------SPEKAER--------VVNELVR 287 Query: 363 -LRPV-APMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420 L PV AP P A D I + G V+ ++ + +E PD R Sbjct: 288 YLSPVQAPN--PRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPDVLDANR---- 341 Query: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 +VS + FG G C+G LAR L + L +RF Sbjct: 342 -------AAVSDVGFGHGIHYCVGAALARSMLRMAYQTLWRRF 377 >5VWS-A nrPDB Length = 393 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 53/222 (23%), Positives = 89/222 (40%), Gaps = 43/222 (19%) Query: 243 LNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGA 302 +N L + R+ ++L L+QA++ + + L ++ T + A Sbjct: 185 MNDYLREHCRSRRTHPRDDLLTRLVQAEV-----------EGKRLDLEEVVNTASLLLLA 233 Query: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLR 362 G TTT ++ T+ L +P+ +K + + P+ L+ A + E LR Sbjct: 234 GHLTTTVLIGNTMLCLWDHPEAEKAVRAD----------PS--------LIPAALEESLR 275 Query: 363 LRPVAPMLIPHKANV-DSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA 421 LR +P L + D +I + V+ W L N + PD PERF Sbjct: 276 LR--SPFLQAGRVTTRDVTIAGETIPANRFVMA--WILSANHDDRRFPD---PERF---- 324 Query: 422 GTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 L + ++ FG G C+G L R E + + LL RF Sbjct: 325 --DLHRQTTGHIAFGHGVHFCLGAQLGRLEGRIALERLLGRF 364 >4JBT-A nrPDB Length = 410 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 41/178 (23%), Positives = 71/178 (39%), Gaps = 29/178 (16%) Query: 287 LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD 346 L++ ++ + + AG ETT S++ + LL +P+ +L D +G+ Sbjct: 229 LTEEEVIGNLQALVAAGHETTVSLILTAVRALLSHPE---QLRLVRDGEIGW-------- 277 Query: 347 RNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHN-EKE 405 E I E LR L+ A D +G+ + +G V+++ A+ + Sbjct: 278 -------ETAIEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVH 330 Query: 406 WHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 D F R + + ++ FG GP C G LAR E + + L RF Sbjct: 331 GADADDFDITR----------ATAARHISFGHGPHICPGAALARLEAAIALPALFTRF 378 >5HDI-A nrPDB Length = 404 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 47/186 (25%), Positives = 79/186 (42%), Gaps = 43/186 (23%) Query: 299 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIR 358 +F AG E+T +++ + L P +++++ R LL A I Sbjct: 241 LFAAGGESTAALLGSAVWILATRPDIQQQV------------------RANPELLGAFIE 282 Query: 359 EVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEV-----IINLW-ALHHNEKEWHQPDQF 412 E LR P P + + +D GTE+ ++ LW A + + ++ P +F Sbjct: 283 ETLRYEP------PFRGHYRHVRNATTLD-GTELPADSHLLLLWGAANRDPAQFEAPGEF 335 Query: 413 MPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFD-LEVPD-D 470 +R AG + ++ FG G C+G LAR E +++ LL R +E D Sbjct: 336 RLDR----AGGK------GHISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVG 385 Query: 471 GQLPSL 476 G LPS+ Sbjct: 386 GWLPSI 391 >4Z5P-A nrPDB Length = 400 Score = 37.7 bits (86), Expect = 0.011, Method: Compositional matrix adjust. Identities = 35/123 (28%), Positives = 52/123 (42%), Gaps = 15/123 (12%) Query: 352 LLEATIREVLRLRPVAPMLIPHK-ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPD 410 LL + E+LR P+ + + A D + V G V+ + + + + PD Sbjct: 269 LLPRAVEELLRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPD 328 Query: 411 QFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF---DLEV 467 + R NP +L FG G C+G LAR EL + + LL+RF L V Sbjct: 329 RLDITREKNP-----------HLAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRLAV 377 Query: 468 PDD 470 P D Sbjct: 378 PAD 380 >5CJE-A nrPDB Length = 393 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 53/220 (24%), Positives = 86/220 (39%), Gaps = 42/220 (19%) Query: 243 LNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGA 302 L++++++ + +D ++L L++ + D+ +G EL + IL A Sbjct: 187 LDELIDDKRSTAPAD---DLLGDLIRTRAEDDDRLSG----EELRAMAFILLV------A 233 Query: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLR 362 G ETT +++ + LL +P L R + LL+ + EVLR Sbjct: 234 GHETTVNLITNGVHTLLTHPDQLAAL------------------RADMTLLDGAVEEVLR 275 Query: 363 LRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAG 422 A IG A+ +G V+I L A + P F R P G Sbjct: 276 FEGPVETATYRYAAESMEIGGTAIAEGDPVMIGLDAAGRDPARHPDPHVFDIHR--APQG 333 Query: 423 TQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 +L FG G C+G LAR E + + LL+R Sbjct: 334 ---------HLAFGHGIHYCLGAPLARLEARVALRSLLER 364 >5EX6-C nrPDB Length = 434 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 30/117 (25%), Positives = 50/117 (42%), Gaps = 12/117 (10%) Query: 354 EATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFM 413 E + E++R V P A DS++G+ + G V+ +L + + D+ Sbjct: 306 ERAVDELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADRL- 364 Query: 414 PERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF-DLEVPD 469 + +V ++ FG G C+G LAR EL + L +RF DL + D Sbjct: 365 ----------DVTREAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLAD 411 >5LIV-A nrPDB Length = 450 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 44/180 (24%), Positives = 72/180 (40%), Gaps = 39/180 (21%) Query: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361 G ETT+ +V T+ LL +P ++ ++ P+ LL A I E + Sbjct: 279 GGYETTSWLVANTIHALLAHPDTLARVRQD----------PS--------LLPAAIEEGM 320 Query: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA 421 R P + + D + + A+ GT V + A +++E + P+ + +R PA Sbjct: 321 RWCP-SSFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDRKPLPA 379 Query: 422 GTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPK 481 FG G C+G LAR E + + LL RF P L +P+ Sbjct: 380 ANV----------FGGGAHFCVGAPLARMEARVGLQALLARF----------PGLRAVPE 419 >6HQG-A nrPDB Length = 425 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 52/199 (26%), Positives = 84/199 (42%), Gaps = 50/199 (25%) Query: 290 NHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNR 349 N IL +G G +TT + + ++ L NP +KL E N G Sbjct: 255 NLILLIVG-----GNDTTRNTISGSVLALHQNPDQDRKLRE----NPG------------ 293 Query: 350 LLLLEATIREVLRLR-PVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408 L+ A + E +R + P+A M +A D +G + +G +V + + + +E+ + Sbjct: 294 --LIPAMVSETIRWQTPLAYMR--RRAKRDFELGGKTIREGDKVAMWYVSGNRDEEVIDR 349 Query: 409 PDQFMPERFLNPAGTQLISPSV-SYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEV 467 P+ + ER P V +L FG G C+G LA +L +I +L RF Sbjct: 350 PNDYWIER-----------PRVRQHLSFGFGVHRCVGNRLAELQLKIIWEEILARF---- 394 Query: 468 PDDGQLPSLE--GIPKVVF 484 P LE G P+ V+ Sbjct: 395 ------PRLEVVGPPRRVY 407 >5DE9-A nrPDB Length = 410 Score = 37.4 bits (85), Expect = 0.016, Method: Compositional matrix adjust. Identities = 54/217 (24%), Positives = 82/217 (37%), Gaps = 56/217 (25%) Query: 254 FRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313 RSDS + +L+ A + +D LS+ L + I G E T+ Sbjct: 205 LRSDSAGEDVTSLLGAAVG---------RDEITLSEAVGLAVLLQIGG---EAVTNNSGQ 252 Query: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 373 LL P++ ++L E P I R I E+LR IPH Sbjct: 253 MFHLLLSRPELAERLRSE----------PEIRPR--------AIDELLRW-------IPH 287 Query: 374 KANV--------DSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQL 425 + V D I + G V ++ A + + + + PD+ ER NP Sbjct: 288 RNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFERSPNP----- 342 Query: 426 ISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 ++ FG GP C G +LAR E L++ +L R Sbjct: 343 ------HVSFGFGPHYCPGGMLARLESELLVDAVLDR 373 >6G5O-A nrPDB Length = 399 Score = 37.4 bits (85), Expect = 0.017, Method: Compositional matrix adjust. Identities = 34/164 (20%), Positives = 71/164 (43%), Gaps = 32/164 (19%) Query: 300 FGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIRE 359 F G +T + V ++A+L +P+ ++L +E P I+ R + E Sbjct: 218 FAGGRDTVINAVTNSIAYLAEHPEALERLRKE----------PEITGR--------AVEE 259 Query: 360 VLR-LRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418 ++R P+ M D+ + E AV + + + + + + + P++ + +R + Sbjct: 260 MIRYFSPLTQM--GRVVTEDTHVCEHAVKADSRISLCWASANRDAAVFENPNEIVLDRKV 317 Query: 419 NPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 NP ++ FG +C+G ARQ L +++ L Q+ Sbjct: 318 NP-----------HVGFGFSHHNCLGATHARQILKILLQTLAQK 350 >4OQR-A nrPDB Length = 457 Score = 37.0 bits (84), Expect = 0.020, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 49/109 (44%), Gaps = 11/109 (10%) Query: 356 TIREVLRLRPVAPMLIPHKANV-DSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMP 414 + E+LR + + P++A + D + + KG V I L A++ + K + +PD Sbjct: 310 AVEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQL 369 Query: 415 ERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 +R + + FG G C+G+ LAR E+ + L RF Sbjct: 370 DRV----------DARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARF 408 >3WEC-A nrPDB Length = 419 Score = 37.0 bits (84), Expect = 0.020, Method: Compositional matrix adjust. Identities = 51/190 (26%), Positives = 73/190 (38%), Gaps = 46/190 (24%) Query: 279 GPDQDSELLSDNHILTTIGDIFGAGVETTTSVV-KWTLAFLLHNPQVKKKLYEEIDQNVG 337 G DQ LS + I T I AG ETT++ + + F H Q +E++ N Sbjct: 234 GGDQ----LSVDEIAATCLLITVAGQETTSNTIGNMLITFSRHADQ-----FEQVRANPQ 284 Query: 338 FSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKAN----VDSSIGEFAVDKGTEVI 393 F +E + EVLR P A H+A D + + KG V+ Sbjct: 285 F--------------IENAVAEVLRFEPPA-----HEAGRIALEDCEVSGANITKGDAVM 325 Query: 394 INLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELF 453 + L + N + + D F R P VS L +G G C+G LA L Sbjct: 326 VLLAS--GNREAVERGDTFSVTR-----------PDVSSLSYGRGIHHCLGSALANSMLQ 372 Query: 454 LIMAWLLQRF 463 + L QR+ Sbjct: 373 HFLRELSQRY 382 >4OQS-A nrPDB Length = 433 Score = 37.0 bits (84), Expect = 0.023, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 49/109 (44%), Gaps = 11/109 (10%) Query: 356 TIREVLRLRPVAPMLIPHKANV-DSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMP 414 + E+LR + + P++A + D + + KG V I L A++ + K + +PD Sbjct: 271 AVEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQL 330 Query: 415 ERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 +R + + FG G C+G+ LAR E+ + L RF Sbjct: 331 DRV----------DARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARF 369 >6GK6-A nrPDB Length = 411 Score = 36.6 bits (83), Expect = 0.023, Method: Compositional matrix adjust. Identities = 41/177 (23%), Positives = 72/177 (40%), Gaps = 29/177 (16%) Query: 287 LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD 346 LS + + + + AG ETT ++ + LL +P +++L D++ G Sbjct: 228 LSPAELSSMVFLLLVAGHETTVHLIASGMLLLLSHPAERRRL----DEDPG--------- 274 Query: 347 RNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW 406 L+ + + E LR A + + D + V G V L A + + + + Sbjct: 275 -----LVGSAVEEALRCEGPAELSTIRWSLEDIELFGARVPAGEGVAAGLLAANRDPQHF 329 Query: 407 HQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 PD+F R N ++ FG G C+G +LAR E + + LL+R Sbjct: 330 PDPDRFDIGRSPN-----------RHIGFGGGIHFCLGAMLARIEAAIAFSTLLRRL 375 >1Z8P-A nrPDB Length = 404 Score = 36.6 bits (83), Expect = 0.025, Method: Compositional matrix adjust. Identities = 52/236 (22%), Positives = 100/236 (42%), Gaps = 45/236 (19%) Query: 230 EKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSD 289 E+ + + +++N IL + E+ R++ ++L L++ + + D+G D+ Sbjct: 180 ERAEQRGQAAREVVNFIL-DLVERRRTEPGDDLLSALIRVQ-DDDDGRLSADE------- 230 Query: 290 NHILTTIGDIFG-AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348 LT+I + AG E++ S++ LL +P DQ R P+ Sbjct: 231 ---LTSIALVLLLAGFESSVSLIGIGTYLLLTHP----------DQLALVRRDPSA---- 273 Query: 349 RLLLLEATIREVLRLRPVAPMLIPHK-ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWH 407 L + E+LR +AP + A + IG A+ + + V++ A + + K++ Sbjct: 274 ----LPNAVEEILRY--IAPPETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFP 327 Query: 408 QPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 P +F + + +L FG G C+G LA+ E + + L RF Sbjct: 328 DPHRF-----------DVTRDTRGHLSFGQGIHFCMGRPLAKLEGEVALRALFGRF 372 >6F88-A nrPDB Length = 400 Score = 36.6 bits (83), Expect = 0.026, Method: Compositional matrix adjust. Identities = 44/180 (24%), Positives = 72/180 (40%), Gaps = 39/180 (21%) Query: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361 G ETT+ +V T+ LL +P ++ ++ P+ LL A I E + Sbjct: 229 GGYETTSWLVANTIHALLAHPDTLARVRQD----------PS--------LLPAAIEEGM 270 Query: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA 421 R P + + D + + A+ GT V + A +++E + P+ + +R PA Sbjct: 271 RWCP-SNFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDRKPLPA 329 Query: 422 GTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPK 481 FG G C+G LAR E + + LL RF P L +P+ Sbjct: 330 ANV----------FGGGAHFCVGAPLARMEARVGLQALLARF----------PGLRAVPE 369 >2FR7-A nrPDB Length = 412 Score = 36.6 bits (83), Expect = 0.029, Method: Compositional matrix adjust. Identities = 17/85 (20%), Positives = 43/85 (50%), Gaps = 11/85 (12%) Query: 378 DSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGA 437 D + + +G +V++ L + + + + W PD++ + + ++ FG+ Sbjct: 308 DVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRY-----------DITRKTSGHVGFGS 356 Query: 438 GPRSCIGEILARQELFLIMAWLLQR 462 G C+G+++AR E +++A L ++ Sbjct: 357 GVHMCVGQLVARLEGEVVLAALARK 381 >4UBS-A nrPDB Length = 393 Score = 36.2 bits (82), Expect = 0.037, Method: Compositional matrix adjust. Identities = 48/221 (21%), Positives = 88/221 (39%), Gaps = 41/221 (18%) Query: 243 LNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGA 302 L+ L ++ R + +LD L+Q ++N G +EL+S L T+ + A Sbjct: 184 LDDYLYALIDRKRKEPGDGLLDDLIQEQLNR-----GTVDRAELVS----LATL--LLIA 232 Query: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLR 362 G ETT +++ LL +P+ +L E L+ A + E+LR Sbjct: 233 GHETTANMISLGTFTLLRHPEQLAELRAEPG------------------LMPAAVEELLR 274 Query: 363 LRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAG 422 +A L+ A D + + V+ ++ + + +PD R Sbjct: 275 FLSIADGLL-RVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHR------ 327 Query: 423 TQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 + ++ FG G C+G+ LAR E+ + + L +R Sbjct: 328 -----SARHHVAFGFGIHQCLGQNLARAEMEIALGTLFERL 363 >4PWV-A nrPDB Length = 446 Score = 34.7 bits (78), Expect = 0.100, Method: Compositional matrix adjust. Identities = 29/110 (26%), Positives = 44/110 (40%), Gaps = 12/110 (10%) Query: 347 RNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW 406 R+ + LE+ EVLR A M +A D + + G ++ LW N E Sbjct: 297 RDGKVTLESATEEVLRWATPA-MHFGRRAVTDMELHGQVIAAGD--VVTLWNNSANRDE- 352 Query: 407 HQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIM 456 E F +P L ++ FG GP C+G L R E+ ++ Sbjct: 353 --------EVFADPYAFDLNRSPNKHITFGYGPHFCLGAYLGRAEVHALL 394 >1CPT-A nrPDB Length = 428 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 29/131 (22%), Positives = 56/131 (42%), Gaps = 16/131 (12%) Query: 336 VGFSRTP---TISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEV 392 +G SR P ++ + L+ V PV + A D+ + + +G + Sbjct: 281 IGLSRNPEQLALAKSDPALIPRLVDEAVRWTAPVKSFM--RTALADTEVRGQNIKRGDRI 338 Query: 393 IINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQEL 452 +++ + + +E+ + PD+F RF N +L FG G C+G+ LA+ E+ Sbjct: 339 MLSYPSANRDEEVFSNPDEFDITRFPN-----------RHLGFGWGAHMCLGQHLAKLEM 387 Query: 453 FLIMAWLLQRF 463 + LL + Sbjct: 388 KIFFEELLPKL 398 >4DO1-A nrPDB Length = 410 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 16/82 (19%), Positives = 42/82 (51%), Gaps = 11/82 (13%) Query: 381 IGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPR 440 +G + +G +V++ L + + + + W PD + + + ++ FG+G Sbjct: 309 LGGAVIGEGEKVLMFLGSANRDPRRWSDPDLY-----------DITRKTSGHVGFGSGVH 357 Query: 441 SCIGEILARQELFLIMAWLLQR 462 C+G+++AR E ++++ L ++ Sbjct: 358 MCVGQLVARLEGEVMLSALARK 379 >2IAG-A nrPDB Length = 482 Score = 32.7 bits (73), Expect = 0.41, Method: Compositional matrix adjust. Identities = 36/138 (26%), Positives = 64/138 (46%), Gaps = 22/138 (15%) Query: 352 LLEATIREVLRLRPVAPMLIPHKANVDSSI-----GEFAVDKGTEVIINLWALHHNEKE- 405 +L++ + E LRL A I + VD ++ EF + +G +++ + + E Sbjct: 318 VLDSVLSESLRL--TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEI 375 Query: 406 WHQPDQFMPERFLNPAGTQLISPSVS-------YLPFGAGPRSCIGEILA----RQELFL 454 + P+ F RFLNP G++ +P+GAG C+G A +Q +FL Sbjct: 376 YTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFL 435 Query: 455 IMAWL---LQRFDLEVPD 469 ++ L L D+E+P+ Sbjct: 436 VLVHLDLELINADVEIPE 453 >3NV6-A nrPDB Length = 452 Score = 32.3 bits (72), Expect = 0.44, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 24/46 (52%) Query: 429 SVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLP 474 S+S+ FG GP C G LAR E+ + + L+R +G+ P Sbjct: 386 SISHSTFGGGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGETP 431 >6CA8-A nrPDB Length = 751 Score = 32.3 bits (72), Expect = 0.52, Method: Compositional matrix adjust. Identities = 32/117 (27%), Positives = 53/117 (45%), Gaps = 22/117 (18%) Query: 116 DSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAV 175 D+ A + +LA +T ++F + D + K + +E GQ I+ + + Sbjct: 356 DASAARYIFTKLASSTRSIFNEYDDPILKYLNEE------------GQKIEPQYYI---- 399 Query: 176 TNVISLICFNTSYKNGDPELNVIQNYN-EGIIDNL----SKDSLVDLVPWLKIFPNK 227 VI I N G + I NYN + IIDN+ +K+ L+ +VPW K F + Sbjct: 400 -PVIPTILVNGCEGIGTGYSSFIPNYNYKDIIDNIKRYINKEPLIPMVPWYKDFKGR 455 >5Z9I-A nrPDB Length = 398 Score = 32.0 bits (71), Expect = 0.61, Method: Compositional matrix adjust. Identities = 34/151 (22%), Positives = 62/151 (41%), Gaps = 24/151 (15%) Query: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPML-IP 372 T A L+ N + + + D V R+ L+ A + E +R ++P+ + Sbjct: 241 TTAMLIANTMLCLDAFSDQDARVRADRS----------LVPALLEESMRY--MSPICGVG 288 Query: 373 HKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSY 432 N + + + K +++ A + +E+++ +PD F R N ++ Sbjct: 289 RATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGRSPN-----------AH 337 Query: 433 LPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 L FG G C+G LAR E + LL R Sbjct: 338 LGFGRGIHFCLGRQLARMESKAAVEILLDRL 368 >5DQN-A nrPDB Length = 426 Score = 32.0 bits (71), Expect = 0.61, Method: Compositional matrix adjust. Identities = 45/178 (25%), Positives = 72/178 (40%), Gaps = 35/178 (19%) Query: 281 DQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSR 340 D D E LSD+ + + AG ETT + + + NP + +LY++ R Sbjct: 230 DIDGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFAQNPD-QWELYKK-------ER 281 Query: 341 TPTISDRNRLLLLEATIREVLR-LRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWAL 399 T +D E++R PV+ A D +G + KG V+++ + Sbjct: 282 PETAAD------------EIVRWATPVS--AFQRTALEDVELGGVQIKKGQRVVMSYRSA 327 Query: 400 HHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGA-GPRSCIGEILARQELFLIM 456 + +E+ + P F R NP ++ FG G CIG LAR + LI Sbjct: 328 NFDEEVFEDPHTFNILRSPNP-----------HVGFGGTGAHYCIGANLARMTINLIF 374 >2QBO-A nrPDB Length = 421 Score = 32.0 bits (71), Expect = 0.62, Method: Compositional matrix adjust. Identities = 17/51 (33%), Positives = 27/51 (52%), Gaps = 1/51 (1%) Query: 430 VSYLPFGAGPRSCIGEILARQELFLIM-AWLLQRFDLEVPDDGQLPSLEGI 479 VS+ FG G C+G+ LAR+E+ + + WL + D + Q+ GI Sbjct: 346 VSHTTFGHGSHLCLGQHLARREIIVTLKEWLTRIPDFSIAPGAQIQHKSGI 396 >5OWV-A nrPDB Length = 732 Score = 31.6 bits (70), Expect = 0.75, Method: Compositional matrix adjust. Identities = 24/82 (29%), Positives = 48/82 (58%), Gaps = 3/82 (3%) Query: 189 KNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILE 248 KN +LN+ + N I+D +KD + D++ +K K +E+LK+++ ++ D L + Sbjct: 537 KNNAQKLNLSRILN--IVDITTKDGINDILREIKFENIKKIEELKTNLSLKYDFLKDDFD 594 Query: 249 NYKEKFRSDSITNMLDTLMQAK 270 N E F+ D I+ +D++ Q++ Sbjct: 595 NGFEGFK-DGISKNIDSIFQSE 615 >3A50-A nrPDB Length = 411 Score = 31.6 bits (70), Expect = 0.94, Method: Compositional matrix adjust. Identities = 49/210 (23%), Positives = 84/210 (40%), Gaps = 41/210 (19%) Query: 243 LNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGA 302 L+ L + E+ R++ +L +L+ D D + LS ++ + A Sbjct: 187 LHGYLSDLLERKRTEPDDALLSSLLAVS----------DMDGDRLSQEELVAMAMLLLIA 236 Query: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLR 362 G ETT +++ + LL +P +K L E+ P+ L+ + + E LR Sbjct: 237 GHETTVNLIGNGVLALLTHPDQRKLLAED----------PS--------LISSAVEEFLR 278 Query: 363 L-RPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA 421 PV+ I A D + + G V++ L A + + +W MPE P Sbjct: 279 FDSPVSQAPIRFTAE-DVTYSGVTIPAGEMVMLGL-AAANRDADW------MPE----PD 326 Query: 422 GTQLISPSVSYLPFGAGPRSCIGEILARQE 451 + + + FG G C+G LAR E Sbjct: 327 RLDITRDASGGVFFGHGIHFCLGAQLARLE 356 >1LG9-A nrPDB Length = 398 Score = 31.2 bits (69), Expect = 1.0, Method: Compositional matrix adjust. Identities = 26/110 (23%), Positives = 44/110 (40%), Gaps = 11/110 (10%) Query: 354 EATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFM 413 + + E++R V P A D ++ + KG VI +L A + + D+ Sbjct: 270 QRAVDELIRYLTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRL- 328 Query: 414 PERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 + + ++ FG G C+G LAR EL + L +RF Sbjct: 329 ----------DVTREPIPHVAFGHGVHHCLGAALARLELRTVFTELWRRF 368 >4BDV-A nrPDB Length = 760 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 20/64 (31%), Positives = 33/64 (51%), Gaps = 6/64 (9%) Query: 366 VAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL-NPAGTQ 424 + P+LI +K +VD + DK + L+++ + W+ + +RFL NPAG Q Sbjct: 548 IGPLLICYKESVDQRGNQIMSDKRNVI---LFSVFDENRSWYLTENI--QRFLPNPAGVQ 602 Query: 425 LISP 428 L P Sbjct: 603 LEDP 606 >3ZHP-A nrPDB Length = 340 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 25/90 (27%), Positives = 41/90 (45%), Gaps = 15/90 (16%) Query: 20 RRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY-GPIYSVRMGTKTTVIVGH 78 RR G + P ++ ++ H H+ F L K Y P ++R G + H Sbjct: 109 RRQIGTRSP----------TVEYISAHPHI---LFMLLKGYEAPQIALRCGIMLRECIRH 155 Query: 79 HQLAKEVLIK-KGKDFSGRPQMATLDIASN 107 LAK +L + +DF +++T DIAS+ Sbjct: 156 EPLAKIILFSNQFRDFFKYVELSTFDIASD 185 >6HQW-A nrPDB Length = 445 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 27/112 (24%), Positives = 53/112 (47%), Gaps = 13/112 (11%) Query: 352 LLEATIREVLR-LRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPD 410 L+ ++E +R + P+A M A D+ + + G +VI+ + + +E + PD Sbjct: 315 LIPNAVQECIRYVTPLAHMR--RTATADTELFGNQIKAGEKVILWYISANRDETVFENPD 372 Query: 411 QFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 + M +R P + +L FG G C+G LA +L +++ + +R Sbjct: 373 KLMVDR---PNARR-------HLSFGHGIHRCVGARLAELQLRILLEEMHER 414 >6HQD-A nrPDB Length = 420 Score = 30.0 bits (66), Expect = 2.6, Method: Compositional matrix adjust. Identities = 30/118 (25%), Positives = 54/118 (45%), Gaps = 13/118 (11%) Query: 347 RNRLLLLEATIREVLRLR-PVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKE 405 RN LL + I EV+R + P+A M A D + KG +V++ + + +++ Sbjct: 286 RNNRALLASVIPEVVRWQTPIAHMR--RTALEDVEFRGKQIRKGDKVVMWYLSGNRDDEV 343 Query: 406 WHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 +P F+ +R P +L FG G C+G LA +L ++ + +R+ Sbjct: 344 IDRPMDFIADR---PRARH-------HLSFGFGIHRCLGNRLAELQLKILWEEMCERY 391 >5OMS-A nrPDB Length = 409 Score = 29.6 bits (65), Expect = 3.3, Method: Compositional matrix adjust. Identities = 17/73 (23%), Positives = 33/73 (45%), Gaps = 11/73 (15%) Query: 389 GTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILA 448 GT V+++ + +H+ ++ P Q+ L P + +L FGAG +C G A Sbjct: 316 GTPVMLSYGSANHDTGKYEAPSQY-----------DLHRPPLPHLAFGAGNHACAGIYFA 364 Query: 449 RQELFLIMAWLLQ 461 + + + L + Sbjct: 365 NHVMRIALEELFE 377 >3CDK-A nrPDB Length = 241 Score = 29.6 bits (65), Expect = 3.4, Method: Compositional matrix adjust. Identities = 21/80 (26%), Positives = 31/80 (38%) Query: 304 VETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRL 363 V V W L LL N Q+KK + + +N F R + L+ + T+ E +R Sbjct: 53 VSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGTLAERIRA 112 Query: 364 RPVAPMLIPHKANVDSSIGE 383 V +SI E Sbjct: 113 GGAGIPGFYTATGVGTSIAE 132 >4BN9-A nrPDB Length = 201 Score = 29.6 bits (65), Expect = 3.6, Method: Compositional matrix adjust. Identities = 21/57 (36%), Positives = 29/57 (50%) Query: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPML 370 T+ L N Q ++K+ E I + V FS T S RLL+L ++ L VAP L Sbjct: 11 TIYALGRNVQDEEKVIETIKEAVRFSPTAFNSQTGRLLILTGDAQDKLWDEIVAPEL 67 >2NZA-A nrPDB Length = 413 Score = 29.3 bits (64), Expect = 3.8, Method: Compositional matrix adjust. Identities = 20/78 (25%), Positives = 35/78 (44%), Gaps = 11/78 (14%) Query: 386 VDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGE 445 + G V ++ A + + + PD+ +R NP +L +G G C G Sbjct: 311 IAAGEPVYVSYLAANRDPDVFPDPDRIDLDRDPNP-----------HLAYGNGHHFCTGA 359 Query: 446 ILARQELFLIMAWLLQRF 463 +LAR + L++ LL+R Sbjct: 360 VLARMQTELLVDTLLERL 377 >3A1L-A nrPDB Length = 425 Score = 29.3 bits (64), Expect = 4.1, Method: Compositional matrix adjust. Identities = 41/175 (23%), Positives = 71/175 (40%), Gaps = 32/175 (18%) Query: 287 LSDNHILTTIGDIFGAGVETTTS-VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTIS 345 LS + I+ T + AG ETTT+ + K L H + + +E+ TP + Sbjct: 239 LSVDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAH-----RDVLDELRT------TPEST 287 Query: 346 DRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKE 405 A + E++R P + A D +G+ + +G+ V+ L + + + Sbjct: 288 --------PAAVEELMRYDPPV-QAVTRWAYEDIRLGDHDIPRGSRVVALLGSANRD--- 335 Query: 406 WHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLL 460 P RF +P + + + FG G C+G LAR E + + LL Sbjct: 336 --------PARFPDPDVLDVHRAAERQVGFGLGIHYCLGATLARAEAEIGLRALL 382 >3OFT-A nrPDB Length = 396 Score = 29.3 bits (64), Expect = 4.2, Method: Compositional matrix adjust. Identities = 36/164 (21%), Positives = 67/164 (40%), Gaps = 35/164 (21%) Query: 299 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIR 358 +FG G++T +++ L +P+ ++ L E D L+ A Sbjct: 232 LFG-GLDTVAAMIGMVALHLARHPEDQRLLRERPD------------------LIPAAAD 272 Query: 359 EVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHN--EKEWHQPDQFMPER 416 E++R P + A+VD+ + KG ++ L ++ HN + P++ +R Sbjct: 273 ELMRRYPTVAVSRNAVADVDAD--GVTIRKGD--LVYLPSVLHNLDPASFEAPEEVRFDR 328 Query: 417 FLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIM-AWL 459 L P + + G G C+G LAR E+ + + WL Sbjct: 329 GLAP---------IRHTTMGVGAHRCVGAGLARMEVIVFLREWL 363 >6CVC-A nrPDB Length = 433 Score = 29.3 bits (64), Expect = 4.3, Method: Compositional matrix adjust. Identities = 42/176 (23%), Positives = 65/176 (36%), Gaps = 32/176 (18%) Query: 283 DSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTP 342 D E LS + I + AG ETT + + + L P + K + + D Sbjct: 252 DGERLSSSEIAMFFILLVVAGNETTRNAISHGMLALSRYPDERAKWWSDFDG-------- 303 Query: 343 TISDRNRLLLLEATIREVLR-LRPVAPMLIPHKANVDSSIGEFAV-DKGTEVIINLWALH 400 L + E++R PV M +VD + A DK + LW Sbjct: 304 ---------LAATAVEEIVRWASPVVYMRRTLSQDVDLRGTKMAAGDK-----VTLWYCS 349 Query: 401 HNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIM 456 N E D + + NP +P V + G G C+G LAR+E+ ++ Sbjct: 350 ANRDEEKFADPWTFDVTRNP------NPQVGF--GGGGAHFCLGANLARREIRVVF 397 >3IVY-A nrPDB Length = 433 Score = 28.9 bits (63), Expect = 4.9, Method: Compositional matrix adjust. Identities = 46/177 (25%), Positives = 70/177 (39%), Gaps = 33/177 (18%) Query: 281 DQDSELLSDNHILTTIGDIFGAGVETT-TSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFS 339 D D E LSD+ + + AG ETT S+ + +AF H Q + LY+++ Sbjct: 247 DIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFAEHPDQWE--LYKKV------- 297 Query: 340 RTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWAL 399 R T +D T + LR D + + KG V++ + Sbjct: 298 RPETAADEIVRWATPVTAFQRTALR-------------DYELSGVQIKKGQRVVMFYRSA 344 Query: 400 HHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIM 456 + +E+ + P F R NP +P V + G G CIG LAR + LI Sbjct: 345 NFDEEVFQDPFTFNILR--NP------NPHVGF--GGTGAHYCIGANLARMTINLIF 391 >4ONJ-A nrPDB Length = 357 Score = 28.5 bits (62), Expect = 7.7, Method: Compositional matrix adjust. Identities = 26/103 (25%), Positives = 42/103 (40%), Gaps = 7/103 (6%) Query: 1 MWELVALLLLTLAYLFW-PKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKK 59 +W+ ++ L + F K C A+ + +LP+ P P + L KK Sbjct: 52 VWDTISRFLYDIEPEFVDSKYFCAAARKRGYIHNLPVENRFPLFPLAPRTIHEALPLSKK 111 Query: 60 YGPIYSVRMGTKTTVI---VGHHQLAKEVLIKKGKDFSGRPQM 99 + P + R TK + +G QL + K +DF G P M Sbjct: 112 WWPSWDPR--TKLNCLQTAIGSAQLTNRIR-KAVEDFDGEPPM 151 >5KYO-A nrPDB Length = 430 Score = 28.5 bits (62), Expect = 8.0, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 23/46 (50%), Gaps = 1/46 (2%) Query: 435 FGAGPRSCIGEILARQELFLIM-AWLLQRFDLEVPDDGQLPSLEGI 479 FG G +C G LAR E+ +++ W + + + DD L GI Sbjct: 372 FGKGSHTCPGAHLARMEMKVVLREWFARIPEFRIEDDAPLRYSNGI 417 >3A52-A nrPDB Length = 400 Score = 28.5 bits (62), Expect = 8.1, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 31/72 (43%), Gaps = 5/72 (6%) Query: 101 TLDIASNNRKGIAFADSGA--HWQLHRR---LAMATFALFKDGDQKLEKIICQEISTLCD 155 +LD+ S N KG G+ W H AMA F + + +E+ I Q TL Sbjct: 206 SLDLLSQNEKGFVLLVEGSLIDWAGHNNDIATAMAEMQGFANAIEVVEQYIRQHPDTLLV 265 Query: 156 MLATHNGQSIDI 167 + A HN + I Sbjct: 266 VTADHNTGGLSI 277 >1ZBU-A nrPDB Length = 349 Score = 28.1 bits (61), Expect = 8.8, Method: Compositional matrix adjust. Identities = 19/73 (26%), Positives = 31/73 (42%), Gaps = 11/73 (15%) Query: 56 LQKKYGPIYSV-RMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAF 114 ++K YG Y V R TK T++ L K G D+ GRP D + R + Sbjct: 260 IRKSYGNFYKVPRSQTKLTIM----------LEKLGMDYDGRPHCGLDDSKNIARIAVRM 309 Query: 115 ADSGAHWQLHRRL 127 G +++ ++ Sbjct: 310 LQDGCELRINEKM 322 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5UYS-A nrPDB 612 e-175 6B82-A nrPDB 548 e-156 4R1Z-A nrPDB 496 e-140 4R20-A nrPDB 469 e-133 2NNH-A nrPDB 460 e-130 5W0C-A nrPDB 455 e-128 4GQS-A nrPDB 448 e-126 4H1N-A nrPDB 446 e-125 1N6B-A nrPDB 443 e-125 6DWN-A nrPDB 433 e-122 3E6I-A nrPDB 430 e-121 2PG7-A nrPDB 426 e-119 3IBD-A nrPDB 423 e-118 5E58-A nrPDB 422 e-118 5E0E-A nrPDB 417 e-117 2HI4-A nrPDB 411 e-115 5VBU-A nrPDB 403 e-113 3QZ1-A nrPDB 401 e-112 6IQ5-A nrPDB 400 e-112 3DL9-A nrPDB 394 e-110 3TBG-A nrPDB 384 e-107 5YLW-A nrPDB 364 e-101 6DA2-A nrPDB 336 1e-92 5VEU-A nrPDB 322 3e-88 3K9V-A nrPDB 293 9e-80 3EL3-A nrPDB 292 2e-79 3MDV-A nrPDB 278 4e-75 6CR2-A nrPDB 274 7e-74 2VE3-A nrPDB 270 9e-73 6AYB-A nrPDB 258 5e-69 4WMZ-A nrPDB 257 7e-69 3S79-A nrPDB 255 4e-68 5JLC-A nrPDB 253 2e-67 3MZS-A nrPDB 249 2e-66 6C94-A nrPDB 246 2e-65 5FSA-A nrPDB 243 1e-64 2WX2-A nrPDB 239 3e-63 3L4D-A nrPDB 233 2e-61 3JUS-A nrPDB 230 1e-60 3N9Z-A nrPDB 226 2e-59 2W0A-A nrPDB 218 5e-57 4KPA-A nrPDB 212 3e-55 2X2N-A nrPDB 203 2e-52 4GGV-A nrPDB 199 2e-51 5L94-A nrPDB 197 9e-51 3EJB-B nrPDB 193 1e-49 5OFQ-A nrPDB 191 7e-49 4RM4-A nrPDB 187 1e-47 6M7X-A nrPDB 183 2e-46 4ZGX-A nrPDB 183 2e-46 2Y5N-A nrPDB 180 1e-45 2VZM-A nrPDB 180 1e-45 4YZR-A nrPDB 178 4e-45 5XW2-A nrPDB 178 6e-45 1ODO-A nrPDB 178 7e-45 4MM0-A nrPDB 177 8e-45 5XNT-A nrPDB 177 1e-44 6GMF-A nrPDB 176 2e-44 3WVS-A nrPDB 176 3e-44 4YT3-A nrPDB 174 6e-44 6A7J-A nrPDB 173 3e-43 3ABB-A nrPDB 169 3e-42 2Z36-A nrPDB 168 5e-42 5LIE-A nrPDB 168 8e-42 5IT1-A nrPDB 167 1e-41 6A7I-A nrPDB 166 3e-41 5Y1I-A nrPDB 165 4e-41 3NC3-A nrPDB 165 4e-41 6B11-A nrPDB 165 4e-41 3TYW-A nrPDB 165 5e-41 4WPZ-A nrPDB 165 5e-41 3ABA-A nrPDB 164 6e-41 1GWI-A nrPDB 164 6e-41 3R9C-A nrPDB 164 9e-41 5XJN-A nrPDB 163 2e-40 5GWE-A nrPDB 162 2e-40 2WIO-A nrPDB 162 3e-40 4TRI-A nrPDB 161 8e-40 5FOI-A nrPDB 161 1e-39 3SN5-A nrPDB 160 1e-39 1F4U-A nrPDB 158 5e-39 1EHE-A nrPDB 158 6e-39 3P3Z-A nrPDB 156 3e-38 2XKR-A nrPDB 151 5e-37 1Q5D-A nrPDB 151 5e-37 2X9P-A nrPDB 151 1e-36 2RFC-A nrPDB 150 1e-36 6F0B-A nrPDB 149 2e-36 6M7L-A nrPDB 149 2e-36 5L1U-A nrPDB 149 3e-36 6FYJ-A nrPDB 146 2e-35 3RWL-A nrPDB 144 9e-35 1UE8-A nrPDB 142 4e-34 5FYF-A nrPDB 142 4e-34 3MGX-A nrPDB 142 4e-34 3TKT-A nrPDB 139 2e-33 2ZQJ-A nrPDB 132 4e-31 5HIW-A nrPDB 130 1e-30 1WIY-A nrPDB 127 9e-30 3AWQ-A nrPDB 123 2e-28 2WIY-A nrPDB 122 4e-28 2IJ7-A nrPDB 122 5e-28 5M0P-A nrPDB 120 1e-27 3BUJ-A nrPDB 117 8e-27 Sequences not found previously or not previously below threshold: 5VWS-A nrPDB 185 4e-47 4Z5P-A nrPDB 182 4e-46 4UBS-A nrPDB 178 4e-45 5CJE-A nrPDB 178 7e-45 2ZBZ-A nrPDB 171 6e-43 4JBT-A nrPDB 170 1e-42 3A50-A nrPDB 169 2e-42 4OQS-A nrPDB 165 5e-41 5NWS-A nrPDB 164 9e-41 4OQR-A nrPDB 163 2e-40 1Z8P-A nrPDB 159 3e-39 5EX6-C nrPDB 158 6e-39 1UED-A nrPDB 157 1e-38 4XE3-A nrPDB 155 4e-38 1CPT-A nrPDB 155 4e-38 6GK6-A nrPDB 155 5e-38 1LG9-A nrPDB 153 2e-37 4Z5Q-A nrPDB 152 3e-37 5YSW-A nrPDB 152 4e-37 5Z9I-A nrPDB 151 6e-37 6HQG-A nrPDB 150 2e-36 6FSH-A nrPDB 149 2e-36 4TX3-A nrPDB 144 6e-35 2WM5-A nrPDB 144 7e-35 6HQW-A nrPDB 141 5e-34 6CVC-A nrPDB 141 8e-34 3A1L-A nrPDB 141 1e-33 5DQN-A nrPDB 138 4e-33 6DCD-A nrPDB 133 2e-31 5HDI-A nrPDB 132 3e-31 2FR7-A nrPDB 132 4e-31 5LIV-A nrPDB 130 2e-30 3IVY-A nrPDB 130 2e-30 6F88-A nrPDB 129 2e-30 4DO1-A nrPDB 128 5e-30 6G5O-A nrPDB 127 9e-30 5DE9-A nrPDB 127 1e-29 5HH3-A nrPDB 126 2e-29 6GII-A nrPDB 126 2e-29 6HQD-A nrPDB 126 3e-29 2UUQ-A nrPDB 125 5e-29 3WEC-A nrPDB 124 6e-29 3OO3-A nrPDB 124 9e-29 5H1Z-A nrPDB 123 2e-28 4PWV-A nrPDB 122 2e-28 2NZA-A nrPDB 118 5e-27 6BLD-A nrPDB 116 3e-26 4FB2-A nrPDB 115 4e-26 5EX8-A nrPDB 115 6e-26 3OFT-A nrPDB 114 7e-26 5KYO-A nrPDB 111 8e-25 6G71-A nrPDB 109 2e-24 5YHJ-A nrPDB 107 1e-23 5OMS-A nrPDB 106 2e-23 2QBO-A nrPDB 105 3e-23 5D3U-A nrPDB 100 2e-21 2IAG-A nrPDB 99 3e-21 3B98-A nrPDB 94 2e-19 3NV6-A nrPDB 91 2e-18 4C9K-A nrPDB 85 7e-17 2RCM-A nrPDB 82 6e-16 3DBM-A nrPDB 72 5e-13 2YJN-B nrPDB 59 7e-09 4YXC-B nrPDB 35 0.096 4YXB-D nrPDB 32 0.45 2NYG-A nrPDB 32 0.54 4E22-A nrPDB 30 3.4 3RFT-A nrPDB 29 5.5 2ZX8-A nrPDB 29 6.4 >5UYS-A nrPDB Length = 494 Score = 612 bits (1578), Expect = e-175, Method: Composition-based stats. Identities = 485/485 (100%), Positives = 485/485 (100%) Query: 24 GAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAK 83 GAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAK Sbjct: 6 GAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAK 65 Query: 84 EVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLE 143 EVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLE Sbjct: 66 EVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLE 125 Query: 144 KIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNE 203 KIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNE Sbjct: 126 KIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNE 185 Query: 204 GIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNML 263 GIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNML Sbjct: 186 GIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNML 245 Query: 264 DTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQ 323 DTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQ Sbjct: 246 DTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQ 305 Query: 324 VKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGE 383 VKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGE Sbjct: 306 VKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGE 365 Query: 384 FAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCI 443 FAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCI Sbjct: 366 FAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCI 425 Query: 444 GEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 503 GEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ Sbjct: 426 GEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 485 Query: 504 AEGST 508 AEGST Sbjct: 486 AEGST 490 >6B82-A nrPDB Length = 509 Score = 548 bits (1412), Expect = e-156, Method: Composition-based stats. Identities = 235/497 (47%), Positives = 326/497 (65%), Gaps = 15/497 (3%) Query: 19 KRRCPGAK-------------YPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYS 65 K+ K P SL SLP++GSL L H F LQKKYG +YS Sbjct: 3 KKTSSKGKKQKMNGFVPAGNRSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDLYS 62 Query: 66 VRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHR 125 + MG+ +IV +H AKE+LIKKGK F+GRP+ T D+ + + K IAFAD + W+ HR Sbjct: 63 LMMGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHR 122 Query: 126 RLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFN 185 ++ +F +G +EKIIC+E S++C++L ++D+ + AVTNV+ +CFN Sbjct: 123 KMVHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFN 182 Query: 186 TSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNK 245 +SYK GD E + Y++GI+D ++KDSLVD+ PWL+IFPNK L L+ + IR+ LL K Sbjct: 183 SSYKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLRILRQCISIRDKLLQK 242 Query: 246 ILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVE 305 E +K + + ++LD L++AK +S+N N+ L+++H+L T+G+IFGAGVE Sbjct: 243 KYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVG--LTEDHVLMTVGEIFGAGVE 300 Query: 306 TTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRP 365 TTT+ +KW++A+L+HNPQV++K+ EE+D +G R P +SDR L LEATI EV+R+RP Sbjct: 301 TTTTTLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRP 360 Query: 366 VAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQL 425 V+P+LIPH A DSS+GE+ V KGT V+IN+W+LHH+EKEW P+ F P RFLN G L Sbjct: 361 VSPLLIPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGL 420 Query: 426 ISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFL 485 PS SYLPFGAG R C+GE LA+ ELFL +AW+LQRF LE+P LP L+G VV Sbjct: 421 CCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQ 480 Query: 486 IDSFKVKIKVRQAWREA 502 FKV KVR W ++ Sbjct: 481 PKKFKVVAKVRADWEKS 497 >4R1Z-A nrPDB Length = 439 Score = 496 bits (1276), Expect = e-140, Method: Composition-based stats. Identities = 217/435 (49%), Positives = 301/435 (69%), Gaps = 2/435 (0%) Query: 68 MGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRL 127 MG+ +IV +H AKE+LIKKGK F+GRP+ T D+ + + K IAFAD + W+ HR++ Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKM 60 Query: 128 AMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTS 187 +F +G +EKIIC+E S++C++L ++D+ + AVTNV+ +CFN+S Sbjct: 61 VHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSS 120 Query: 188 YKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKIL 247 YK GD E + Y++GI+D ++KDSLVD+ PWL+IFPNK L L+ + IR+ LL K Sbjct: 121 YKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLTILRQCISIRDKLLQKKY 180 Query: 248 ENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETT 307 E +K + + ++LD L++AK +S+N N+ L+++H+L T+GDIFGAGVETT Sbjct: 181 EEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVG--LTEDHVLMTVGDIFGAGVETT 238 Query: 308 TSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVA 367 T+V+KW++A+L+HNPQV++K+ EE+D +G R P +SDR L LEATIREVLR+RPV+ Sbjct: 239 TTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPVS 298 Query: 368 PMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLIS 427 P+LIPH A DSS+GE+ V KGT V+INLW+LHH++KEW P+ F P RFLN G L Sbjct: 299 PLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEGDGLCC 358 Query: 428 PSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLID 487 PS SYLPFGAG R C+GE LA+ ELFL +AW+LQRF LE+P LP L+G VV Sbjct: 359 PSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPK 418 Query: 488 SFKVKIKVRQAWREA 502 FKV KVR W ++ Sbjct: 419 KFKVVAKVRADWEKS 433 >4R20-A nrPDB Length = 486 Score = 469 bits (1208), Expect = e-133, Method: Composition-based stats. Identities = 203/490 (41%), Positives = 301/490 (61%), Gaps = 25/490 (5%) Query: 19 KRRCPGAKYPKSLLSLPLVGSLPFLPR------------HGHMHNNFFKLQKKYGPIYSV 66 K+ K S+ S P LPR + H F +L +YGP++ + Sbjct: 3 KKTSSKGKEGVGSSSV----SFPCLPRLPLLGSLLHLRSNLPPHLLFTQLSSQYGPLFGL 58 Query: 67 RMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRR 126 G T++V L +EVL+++G++F+GRP+M T D+ + K IAFAD W+ HRR Sbjct: 59 YAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQGGKDIAFADYSPLWKNHRR 118 Query: 127 LAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNT 186 L ++F LF +G KL+ I+ + +LC+ L GQS D+S + AVTNVI + F++ Sbjct: 119 LVHSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSDLSVVLMRAVTNVICRLVFSS 178 Query: 187 SYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKI 246 SY+ DPEL + YN+GI+ +++ LVD+ PWL+IFPNK L++LK V IR+ LL K Sbjct: 179 SYQPSDPELQTVIQYNDGIVQTIARGGLVDIFPWLRIFPNKDLKRLKECVSIRDQLLYKK 238 Query: 247 LENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVET 306 L +K+ ++LD L+ + G+ G D ++++H+L T + FGAGVET Sbjct: 239 LLEHKKSLTPGEPRDLLDALL---IGQQRGSGGADD----ITEDHVLMTAAEAFGAGVET 291 Query: 307 TTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPV 366 T++ + WT+AFLLH+PQ+++++ E+D+ VG R P +SDR L LL+A + EV+R+RPV Sbjct: 292 TSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPHLPLLDAVLCEVMRIRPV 351 Query: 367 APMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLI 426 +P+LIPH A D+S+G +V KGT V++N+WA+HH+ K W QP+QF PERFL P+G + Sbjct: 352 SPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQPEQFNPERFLEPSGKK-- 409 Query: 427 SPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLI 486 S+LPFGAGPR C+GE LAR ELFL ++ LQRF P + LP L+G VV Sbjct: 410 KTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFSCPSEASLPDLQGRFGVVLQP 469 Query: 487 DSFKVKIKVR 496 + + V + R Sbjct: 470 ERYTVTVTPR 479 >2NNH-A nrPDB Length = 476 Score = 460 bits (1184), Expect = e-130, Method: Composition-based stats. Identities = 126/477 (26%), Positives = 226/477 (47%), Gaps = 16/477 (3%) Query: 19 KRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGH 78 K+ K P LP++G++ + + +F K YGP+++V G V+ Sbjct: 3 KKTSSKGKLPPGPTPLPIIGNMLQIDVKD-ICKSFTNFSKVYGPVFTVYFGMNPIVVFHG 61 Query: 79 HQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDG 138 ++ KE LI G++FSGR + + +G W+ RR ++ T F G Sbjct: 62 YEAVKEALIDNGEEFSGRGNSPISQRITKGLG--IISSNGKRWKEIRRFSLTTLRNFGMG 119 Query: 139 DQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPEL-NV 197 + +E + +E L + L D +F + A NVI + F + D + Sbjct: 120 KRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTL 179 Query: 198 IQNYNEGI-IDNLSKDSLVDLVPWL-KIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255 ++ +NE I N + + P L FP + LK+ V + + + ++ ++ Sbjct: 180 MKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKN-VALTRSYIREKVKEHQASLD 238 Query: 256 SDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTL 315 ++ + +D + KM + N + + +++ T+ D+F AG ETT++ +++ L Sbjct: 239 VNNPRDFIDCFL-IKMEQEKDNQKSE-----FNIENLVGTVADLFVAGTETTSTTLRYGL 292 Query: 316 AFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKA 375 LL +P+V K+ EEID +G R+P + DR+ + +A + E+ R + P +PH Sbjct: 293 LLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAV 352 Query: 376 NVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPF 435 D+ + + KGT ++ L ++ H++KE+ P+ F P FL+ G S ++PF Sbjct: 353 TTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGN--FKKSDYFMPF 410 Query: 436 GAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDD-GQLPSLEGIPKVVFLIDSFKV 491 AG R C GE LAR ELFL + +LQ F+L+ DD L + +V L S+++ Sbjct: 411 SAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQI 467 >5W0C-A nrPDB Length = 477 Score = 455 bits (1170), Expect = e-128, Method: Composition-based stats. Identities = 130/477 (27%), Positives = 234/477 (49%), Gaps = 16/477 (3%) Query: 18 PKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVG 77 K K P LP++G++ + + + L K YGP++++ G K V++ Sbjct: 3 KKTSSGRGKLPPGPTPLPVIGNILQIGIKD-ISKSLTNLSKVYGPVFTLYFGLKPIVVLH 61 Query: 78 HHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKD 137 ++ KE LI G++FSGR + +N GI F++ G W+ RR ++ T F Sbjct: 62 GYEAVKEALIDLGEEFSGRGIFPLAER-ANRGFGIVFSN-GKKWKEIRRFSLMTLRNFGM 119 Query: 138 GDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPEL-N 196 G + +E + +E L + L D +F + A NVI I F+ + D + N Sbjct: 120 GKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLN 179 Query: 197 VIQNYNEGI--IDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKF 254 +++ NE I + + + P + FP + LK+ +++ +L K+ E ++E Sbjct: 180 LMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKE-HQESM 238 Query: 255 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314 ++ + +D + KM + N + + + T D+FGAG ETT++ +++ Sbjct: 239 DMNNPQDFIDCFLM-KMEKEKHNQPSE-----FTIESLENTAVDLFGAGTETTSTTLRYA 292 Query: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHK 374 L LL +P+V K+ EEI++ +G +R+P + DR+ + +A + EV R + P +PH Sbjct: 293 LLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHA 352 Query: 375 ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLP 434 D + + KGT ++I+L ++ H+ KE+ P+ F P FL+ G S ++P Sbjct: 353 VTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGN--FKKSKYFMP 410 Query: 435 FGAGPRSCIGEILARQELFLIMAWLLQRFDLE-VPDDGQLPSLEGIPKVVFLIDSFK 490 F AG R C+GE LA ELFL + +LQ F+L+ + D L + + + ++ Sbjct: 411 FSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQ 467 >4GQS-A nrPDB Length = 477 Score = 448 bits (1153), Expect = e-126, Method: Composition-based stats. Identities = 129/473 (27%), Positives = 231/473 (48%), Gaps = 16/473 (3%) Query: 18 PKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVG 77 K K P LP++G++ + + + L K YGP++++ G + V++ Sbjct: 3 KKTSSGRGKLPPGPTPLPVIGNILQIDIKD-VSKSLTNLSKIYGPVFTLYFGLERMVVLH 61 Query: 78 HHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKD 137 +++ KE LI G++FSGR + +N GI F++ G W+ RR ++ T F Sbjct: 62 GYEVVKEALIDLGEEFSGRGHFPLAER-ANRGFGIVFSN-GKRWKEIRRFSLMTLRNFGM 119 Query: 138 GDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPEL-N 196 G + +E + +E L + L D +F + A NVI I F + D + N Sbjct: 120 GKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLN 179 Query: 197 VIQNYNEGI--IDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKF 254 +++ NE I + + + FP + LK+ + +D+L K+ E ++E Sbjct: 180 LMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKE-HQESM 238 Query: 255 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314 ++ + +D + KM + N + + +++ T D+ GAG ETT++ +++ Sbjct: 239 DINNPRDFIDCFL-IKMEKEKQNQQSE-----FTIENLVITAADLLGAGTETTSTTLRYA 292 Query: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHK 374 L LL +P+V K+ EEI++ VG +R+P + DR + +A + EV R + P +PH Sbjct: 293 LLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHA 352 Query: 375 ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLP 434 D + + KGT ++ +L ++ H+ KE+ P+ F P FL+ G S ++P Sbjct: 353 VTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGN--FKKSNYFMP 410 Query: 435 FGAGPRSCIGEILARQELFLIMAWLLQRFDLE-VPDDGQLPSLEGIPKVVFLI 486 F AG R C+GE LAR ELFL + ++LQ F+L+ + D L + + + Sbjct: 411 FSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP 463 >4H1N-A nrPDB Length = 479 Score = 446 bits (1146), Expect = e-125, Method: Composition-based stats. Identities = 121/482 (25%), Positives = 228/482 (47%), Gaps = 16/482 (3%) Query: 19 KRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGH 78 K+ K P LP++G+L + R G + +F +L++KYG +++V +G++ V++ Sbjct: 3 KKTSSKGKLPPGPSPLPVLGNLLQMDRKG-LLRSFLRLREKYGDVFTVYLGSRPVVVLCG 61 Query: 79 HQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDG 138 +E L+ + + FSGR ++A +D G+ FA+ G W+ RR ++AT F G Sbjct: 62 TDAIREALVDQAEAFSGRGKIAVVDPIFQG-YGVIFAN-GERWRALRRFSLATMRDFGMG 119 Query: 139 DQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVI 198 + +E+ I +E L + L G +D + +N+I I F + DP + Sbjct: 120 KRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRL 179 Query: 199 QNYNEGIIDNLSKDS---LVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255 + +S S +LK FP + ++ +I N + + +E ++ Sbjct: 180 LDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEI-NTFIGQSVEKHRATLD 238 Query: 256 SDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTL 315 + + +D + +M D + + +++ T+ +F AG ETT++ +++ Sbjct: 239 PSNPRDFIDVYL-LRMEKDKSDPSSE-----FHHQNLILTVLSLFAAGTETTSTTLRYGF 292 Query: 316 AFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKA 375 +L P V +++ +EI+Q +G R P + DR ++ +A I E+ RL + P +PH Sbjct: 293 LLMLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTV 352 Query: 376 NVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPF 435 D+ + + K TEV L + H+ + + P+ F P FL+ G + + ++PF Sbjct: 353 TKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGA--LKRNEGFMPF 410 Query: 436 GAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGI-PKVVFLIDSFKVKIK 494 G R C+GE +AR ELFL +LQ F + P + L V + S++++ Sbjct: 411 SLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNVPPSYQIRFL 470 Query: 495 VR 496 R Sbjct: 471 AR 472 >1N6B-A nrPDB Length = 473 Score = 443 bits (1139), Expect = e-125, Method: Composition-based stats. Identities = 129/476 (27%), Positives = 236/476 (49%), Gaps = 19/476 (3%) Query: 19 KRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGH 78 K+ K P P++G++ + + + K + YGP+++V +G K TV++ Sbjct: 3 KKTSSKGKLPPGPTPFPIIGNILQIDAKD-ISKSLTKFSECYGPVFTVYLGMKPTVVLHG 61 Query: 79 HQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDG 138 ++ KE L+ G++F+GR + L+ S GIAF++ W+ RR ++ T F G Sbjct: 62 YEAVKEALVDLGEEFAGRGSVPILEKVSKGL-GIAFSN-AKTWKEMRRFSLMTLRNFGMG 119 Query: 139 DQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELN-V 197 + +E I +E L + L N D +F + A NVI + F+ + D E + Sbjct: 120 KRSIEDRIQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKL 179 Query: 198 IQNYNEGI--IDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255 +++ +E + + + L FP LK+ I+N ++ K+ E +++ Sbjct: 180 MESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKE-HQKLLD 238 Query: 256 SDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTL 315 ++ + +D + KM +N + ++ + D+FGAG ETT++ ++++L Sbjct: 239 VNNPRDFIDCFL-IKMEQENNLE--------FTLESLVIAVSDLFGAGTETTSTTLRYSL 289 Query: 316 AFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKA 375 LL +P+V ++ EEI++ +G R+P + DR+R+ +A I E+ R + P +PH Sbjct: 290 LLLLKHPEVAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAV 349 Query: 376 NVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPF 435 D + + KGT++I +L ++ H+EK + P F P FL+ +G S ++PF Sbjct: 350 TRDVRFRNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGN--FKKSDYFMPF 407 Query: 436 GAGPRSCIGEILARQELFLIMAWLLQRFDL-EVPDDGQLPSLEGIPKVVFLIDSFK 490 AG R C+GE LAR ELFL + +LQ F L + + L + V + S++ Sbjct: 408 SAGKRMCVGEGLARMELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPSYQ 463 >6DWN-A nrPDB Length = 491 Score = 433 bits (1113), Expect = e-122, Method: Composition-based stats. Identities = 146/477 (30%), Positives = 237/477 (49%), Gaps = 16/477 (3%) Query: 18 PKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVG 77 K G K P PL+G + L ++ H+ ++ ++YG + +R+G+ V++ Sbjct: 3 KKTSSKGLKNPPGPWGWPLIGHMLTLGKNPHL--ALSRMSQQYGDVLQIRIGSTPVVVLS 60 Query: 78 HHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLA---MATFAL 134 ++ L+++G DF GRP + T + SN + DSG W RRLA + +F++ Sbjct: 61 GLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSI 120 Query: 135 FKDGDQK----LEKIICQEISTLCDMLATHNGQS--IDISFPVFVAVTNVISLICFNTSY 188 D LE+ + +E L L + V V+VTNVI ICF Y Sbjct: 121 ASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRY 180 Query: 189 KNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILE 248 + EL + N N + + + D +P L+ PN +L K + + K+++ Sbjct: 181 DHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVK 240 Query: 249 NYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTT 308 + + F I ++ D+L++ + + LSD I+ + D+FGAG +T T Sbjct: 241 EHYKTFEKGHIRDITDSLIEHCQEKQ----LDENANVQLSDEKIINIVLDLFGAGFDTVT 296 Query: 309 SVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAP 368 + + W+L +L+ NP+V++K+ EE+D +G SR P +SDR+ L +EA I E R P Sbjct: 297 TAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVP 356 Query: 369 MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISP 428 IPH D+S+ F + KG V +N W ++H++K W P +F+PERFL P G Sbjct: 357 FTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVL 416 Query: 429 SVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFL 485 S + FG G R CIGE +AR E+FL +A LLQR + VP ++ + I + Sbjct: 417 SEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKV-DMTPIYGLTMK 472 >3E6I-A nrPDB Length = 476 Score = 430 bits (1105), Expect = e-121, Method: Composition-based stats. Identities = 129/483 (26%), Positives = 241/483 (49%), Gaps = 17/483 (3%) Query: 19 KRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGH 78 K+ K P LP++G+L L ++ +F +L +++GP++++ +G++ V++ Sbjct: 3 KKTSSKGKLPPGPFPLPIIGNLFQLELK-NIPKSFTRLAQRFGPVFTLYVGSQRMVVMHG 61 Query: 79 HQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDG 138 ++ KE L+ +FSGR + + +GI F ++G W+ RR ++ T + G Sbjct: 62 YKAVKEALLDYKDEFSGRGDLPAFHA--HRDRGIIF-NNGPTWKDIRRFSLTTLRNYGMG 118 Query: 139 DQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPEL-NV 197 Q E I +E L + L GQ D +F + A NVI+ I F + D + + Sbjct: 119 KQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRL 178 Query: 198 IQNYNEGI--IDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255 + +NE + + +L P + +K+ V + +++ ++ + + Sbjct: 179 MYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKN-VAEVKEYVSERVKEHHQSLD 237 Query: 256 SDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTL 315 + ++ D L+ +M + +A L + + I T+ D+F AG ETT++ +++ L Sbjct: 238 PNCPRDLTDCLL-VEMEKEKHSAE-----RLYTMDGITVTVADLFFAGTETTSTTLRYGL 291 Query: 316 AFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKA 375 L+ P++++KL+EEID+ +G SR P I DR + ++A + E+ R + P +PH+A Sbjct: 292 LILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEA 351 Query: 376 NVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPF 435 D+ + + KGT V+ L ++ ++ +E+ P++F PE FLN G S + PF Sbjct: 352 TRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK--FKYSDYFKPF 409 Query: 436 GAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP-KVVFLIDSFKVKIK 494 G R C GE LAR ELFL++ +LQ F+L+ D + L I + +K+ + Sbjct: 410 STGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVI 469 Query: 495 VRQ 497 R Sbjct: 470 PRS 472 >2PG7-A nrPDB Length = 476 Score = 426 bits (1094), Expect = e-119, Method: Composition-based stats. Identities = 126/482 (26%), Positives = 228/482 (47%), Gaps = 16/482 (3%) Query: 19 KRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGH 78 K+ K P LP +G+ L M+N+ K+ ++YGP++++ +G + V++ Sbjct: 3 KKTSSKGKLPPGPTPLPFIGNYLQLNTE-QMYNSLMKISERYGPVFTIHLGPRRVVVLCG 61 Query: 79 HQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDG 138 H +E L+ + ++FSGR + AT D G+ F++ G + RR ++AT F G Sbjct: 62 HDAVREALVDQAEEFSGRGEQATFDWVFKG-YGVVFSN-GERAKQLRRFSIATLRDFGVG 119 Query: 139 DQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVI 198 + +E+ I +E L D L G +ID +F + V+NVIS I F + D E + Sbjct: 120 KRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSL 179 Query: 199 QNYNEGIID--NLSKDSLVDLVPW-LKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255 GI + S L ++ +K P + + ++ D + K +E+ + Sbjct: 180 LRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQ-LLQGLEDFIAKKVEHNQRTLD 238 Query: 256 SDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTL 315 +S + +D+ + +M + N + +++ T +F G ET ++ +++ Sbjct: 239 PNSPRDFIDSFL-IRMQEEEKNP-----NTEFYLKNLVMTTLQLFVGGTETVSTTLRYGF 292 Query: 316 AFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKA 375 L+ +P+V+ K++EEID+ +G +R P DR ++ +EA I E+ R V PM + + Sbjct: 293 LLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRV 352 Query: 376 NVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPF 435 D+ +F + KGTEV L ++ + + P F P+ FLN G S +++PF Sbjct: 353 KKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQ--FKKSDAFVPF 410 Query: 436 GAGPRSCIGEILARQELFLIMAWLLQRFDLE-VPDDGQLPSLEGIPKVVFLIDSFKVKIK 494 G R+C GE LAR ELFL ++Q F L+ + + ++ + Sbjct: 411 SIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFL 470 Query: 495 VR 496 R Sbjct: 471 PR 472 >3IBD-A nrPDB Length = 476 Score = 423 bits (1087), Expect = e-118, Method: Composition-based stats. Identities = 130/484 (26%), Positives = 230/484 (47%), Gaps = 20/484 (4%) Query: 19 KRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGH 78 K+ K P LPL+G+L + R G + +F + ++KYG +++V +G + V++ Sbjct: 3 KKTSSKGKLPPGPRPLPLLGNLLQMDRRG-LLKSFLRFREKYGDVFTVHLGPRPVVMLCG 61 Query: 79 HQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDG 138 + +E L+ K + FSGR ++A +D G+ FA+ G W++ RR ++ T F G Sbjct: 62 VEAIREALVDKAEAFSGRGKIAMVDPFFRG-YGVIFAN-GNRWKVLRRFSVTTMRDFGMG 119 Query: 139 DQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVI 198 + +E+ I +E L + L G +D +F N+I I F + D E + Sbjct: 120 KRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKM 179 Query: 199 QNYNEGIIDNLSK---DSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255 N +S +LK FP + K+ +I N + +E ++E Sbjct: 180 LNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEI-NAYIGHSVEKHRETLD 238 Query: 256 SDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTL 315 + +++DT + M + NA + S ++ +F AG ETT++ +++ Sbjct: 239 PSAPRDLIDTYL-LHMEKEKSNAHSE-----FSHQNLNLNTLSLFFAGTETTSTTLRYGF 292 Query: 316 AFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKA 375 +L P V +++Y EI+Q +G R P + DR ++ EA I E+ R + PM +PH Sbjct: 293 LLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIV 352 Query: 376 NVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPF 435 +S + + K TEV + L H+ + +PD F P+ FL+ G + + +++PF Sbjct: 353 TQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGA--LKKTEAFIPF 410 Query: 436 GAGPRSCIGEILARQELFLIMAWLLQRFDLE---VPDDGQLPSLEGIPKVVFLIDSFKVK 492 G R C+GE +AR ELFL +LQ F + P+D L E V + +++++ Sbjct: 411 SLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQEC--GVGKIPPTYQIR 468 Query: 493 IKVR 496 R Sbjct: 469 FLPR 472 >5E58-A nrPDB Length = 493 Score = 422 bits (1085), Expect = e-118, Method: Composition-based stats. Identities = 123/465 (26%), Positives = 226/465 (48%), Gaps = 22/465 (4%) Query: 39 SLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQ 98 +L + R G + N+F ++++KYG +++V +G + V++ + +E L+ + + FSGR Sbjct: 42 NLLQMDRGGFL-NSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGT 100 Query: 99 MATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLA 158 +A + G+ F++ G W++ RR ++AT F G + +E I +E L + L Sbjct: 101 IAVIKPVI-GDYGMIFSN-GERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVEELQ 158 Query: 159 THNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNE---GIIDNLSKDSLV 215 G +D +F N+I I F Y D + + + ++ + S Sbjct: 159 KSQGAPLDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFE 218 Query: 216 DLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDN 275 ++K FP + ++ +I D + + +E ++ + + +DT + +M + Sbjct: 219 LFSGFMKYFPGAHRQITRNLQEIL-DYVGQSVEKHRATLDPSNPRDFIDTYL-LRMEKEK 276 Query: 276 GNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQN 335 N + ++L ++ +F AG ETT++ +++ +L P V +K+ +EIDQ Sbjct: 277 SNQHTE-----FHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQV 331 Query: 336 VGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIIN 395 +G R PT+ DR ++ +A I E+ R +AP+ PHK D+ + + K TEV Sbjct: 332 IGSHRLPTLEDRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPI 391 Query: 396 LWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLI 455 L + H+ + + QP F P+ FL+ G + S +++PF G R C+GE +AR ELFL Sbjct: 392 LSSALHDPQYFEQPGTFNPDHFLDANGA--LKKSEAFMPFSIGKRICLGEGIARNELFLF 449 Query: 456 MAWLLQRFDLE---VPDDGQL-PSLEGIPKVVFLIDSFKVKIKVR 496 +LQ F + P D L P GI KV ++++ R Sbjct: 450 FTTILQNFSVSSSVAPKDIDLSPKESGIGKV---PQTYQISFLAR 491 >5E0E-A nrPDB Length = 463 Score = 417 bits (1072), Expect = e-117, Method: Composition-based stats. Identities = 121/452 (26%), Positives = 218/452 (48%), Gaps = 19/452 (4%) Query: 39 SLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQ 98 +L + R G + N+F ++++KYG +++V +G + V++ + +E L+ + + FSGR Sbjct: 14 NLLQMDRGGFL-NSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGT 72 Query: 99 MATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLA 158 +A ++ G+ FA+ G W+ RR ++ T F G + +E+ I +E L + Sbjct: 73 IAVVEPIFRG-YGVVFAN-GERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEFR 130 Query: 159 THNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDS---LV 215 G +D +F N+I I F + D + + +S S Sbjct: 131 KSQGAPLDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFE 190 Query: 216 DLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDN 275 +LK FP + ++ +I D + + +E ++ + +DT + +M + Sbjct: 191 LFSGFLKYFPGTHRQISRNLQEIL-DYIGQSVEKHRATLDPSHPRDFIDTYL-LRMEKEK 248 Query: 276 GNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQN 335 N + D + +++ ++ +F AG ET+++ +++ +L P V +K+ +EIDQ Sbjct: 249 SNQHTEFDHQ-----NLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQV 303 Query: 336 VGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIIN 395 +G R PT+ DR ++ EA I E+ R + P+ +PHK D+ + + K TEV Sbjct: 304 IGSHRLPTLEDRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPI 363 Query: 396 LWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLI 455 L + H+ + + QPD F P+ FL+ G + S +++PF G R C+GE +AR ELFL Sbjct: 364 LSSALHDPQYFEQPDTFNPDHFLDANGA--LKKSEAFMPFSIGKRICLGEGIARNELFLF 421 Query: 456 MAWLLQRFDLEVP----DDGQLPSLEGIPKVV 483 +LQ F L P D P G KV Sbjct: 422 FTTILQNFSLSSPVAPKDIDLSPKESGFGKVP 453 >2HI4-A nrPDB Length = 495 Score = 411 bits (1056), Expect = e-115, Method: Composition-based stats. Identities = 138/485 (28%), Positives = 236/485 (48%), Gaps = 20/485 (4%) Query: 12 LAYLFWPKRRCPGA-KYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGT 70 +A L + R P K P PL+G + L ++ H+ ++ ++YG + +R+G+ Sbjct: 1 MAVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHL--ALSRMSQRYGDVLQIRIGS 58 Query: 71 KTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLA-- 128 +++ ++ L+++G DF GRP + T + ++ + DSG W RRLA Sbjct: 59 TPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQN 118 Query: 129 -MATFALFKDGDQK----LEKIICQEISTLCDMLATHNGQS--IDISFPVFVAVTNVISL 181 + TF++ D LE+ + +E L L D V V+V NVI Sbjct: 119 ALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGA 178 Query: 182 ICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRND 241 +CF + E+ + ++ S + +D P L+ PN L++ K+ + Sbjct: 179 MCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLW 238 Query: 242 LLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFG 301 L K ++ + + F +S+ ++ L + + GP L+ I+ + DIFG Sbjct: 239 FLQKTVQEHYQDFDKNSVRDITGALFK------HSKKGPRASGNLIPQEKIVNLVNDIFG 292 Query: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361 AG +T T+ + W+L +L+ P++++K+ +E+D +G R P +SDR +L LEA I E Sbjct: 293 AGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETF 352 Query: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA 421 R P IPH D+++ F + K V +N W ++H+ + W P +F PERFL Sbjct: 353 RHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTAD 412 Query: 422 GTQLISP-SVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480 GT + P S + FG G R CIGE+LA+ E+FL +A LLQ+ + VP ++ L I Sbjct: 413 GTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKV-DLTPIY 471 Query: 481 KVVFL 485 + Sbjct: 472 GLTMK 476 >5VBU-A nrPDB Length = 476 Score = 403 bits (1036), Expect = e-113, Method: Composition-based stats. Identities = 145/489 (29%), Positives = 241/489 (49%), Gaps = 35/489 (7%) Query: 19 KRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGH 78 K+ K P P L + L +K+GPIY + +G + V++ Sbjct: 3 KKTSSKGKLPPLA---PGFLHLLQ----PDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNS 55 Query: 79 HQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDG 138 + +E ++KK DF+GRP+ T + S N ++ D W+ H++L + L Sbjct: 56 KRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLG--I 113 Query: 139 DQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVI 198 +E ++ Q C+ + G + I + ++I + F K+ + ++ Sbjct: 114 RDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDN----LM 169 Query: 199 QNYNEGIIDNLSKDS-----LVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK 253 Y + I + L S +VD++P+L+ FPN L +LK ++ R+ ++ L +KE Sbjct: 170 PAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKES 229 Query: 254 FRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313 + +M+D ++Q ++ S L + H+ D+ G ETT + + W Sbjct: 230 LVAGQWRDMMDYMLQGVAQ-----PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSW 284 Query: 314 TLAFLLHNPQVKKKLYEEIDQNVG---FSRTPTISDRNRLLLLEATIREVLRLRPVAPML 370 + FLLH+P+++++L EE+D +G S DR RL LL ATI EVLRLRPV P+ Sbjct: 285 AVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLA 344 Query: 371 IPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSV 430 +PH+ SSI + + +GT +I NL H +E W +P +F P+RFL P + Sbjct: 345 LPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPG------KNS 398 Query: 431 SYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPK--VVFLIDS 488 L FG G R C+GE LAR ELF+++ LLQ F L +P LPSL+ +P V+ + Sbjct: 399 RALAFGCGARVCLGEPLARLELFVVLTRLLQAFTL-LPSGDALPSLQPLPHCSVILKMQP 457 Query: 489 FKVKIKVRQ 497 F+V+++ R Sbjct: 458 FQVRLQPRG 466 >3QZ1-A nrPDB Length = 496 Score = 401 bits (1029), Expect = e-112, Method: Composition-based stats. Identities = 154/486 (31%), Positives = 249/486 (51%), Gaps = 34/486 (6%) Query: 34 LPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDF 93 PLV L ++ + L +K GP+Y +R+G + V++ + +E +I+K DF Sbjct: 31 PPLVPGFLHL-LQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDF 89 Query: 94 SGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTL 153 +GRPQ+ + + S + I+ D W+ H++L + AL +E + Q Sbjct: 90 AGRPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRS--ALLLGTRSSMEPWVDQLTQEF 147 Query: 154 CDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNL---- 209 C+ + G + I + ++I + F + E ++ +++ + D + Sbjct: 148 CERMRVQAGAPVTIQKEFSLLTCSIICYLTFG------NKEDTLVHAFHDCVQDLMKTWD 201 Query: 210 -SKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQ 268 ++D+VP+L+ FPN L +LK ++ R+ ++ K L +KE + +M D ++Q Sbjct: 202 HWSIQILDMVPFLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDYMLQ 261 Query: 269 AKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKL 328 G ++ L + H+ ++ D+F G ETT S + W +AFLLH+P+++++L Sbjct: 262 GV-----GRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRL 316 Query: 329 YEEIDQNVGFSR---TPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFA 385 EE+D+ +G T DR RL LL ATI EVLRLRPV P+ +PH+ SSI + Sbjct: 317 QEELDRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYD 376 Query: 386 VDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGE 445 + +G VI NL H +E W QP +F P+RFL P S L FG G R C+GE Sbjct: 377 IPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANP------SALAFGCGARVCLGE 430 Query: 446 ILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP--KVVFLIDSFKVKIKVR----QAW 499 LAR ELF+++A LLQ F L P G LPSL+ P V + F+V+++ R AW Sbjct: 431 SLARLELFVVLARLLQAFTLLPPPVGALPSLQPDPYCGVNLKVQPFQVRLQPRGVEAGAW 490 Query: 500 REAQAE 505 A A+ Sbjct: 491 ESASAQ 496 >6IQ5-A nrPDB Length = 463 Score = 400 bits (1028), Expect = e-112, Method: Composition-based stats. Identities = 126/461 (27%), Positives = 223/461 (48%), Gaps = 14/461 (3%) Query: 50 HNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNR 109 H +F +L ++YG ++ +R+G+ V++ + + L+++G F+ RP A+ + S R Sbjct: 4 HLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGR 63 Query: 110 KGIAFADSGAHWQLHRRLAMATFALF----KDGDQKLEKIICQEISTLCDML--ATHNGQ 163 +AF HW++ RR A + F Q LE + E L +L + +G Sbjct: 64 S-MAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGA 122 Query: 164 SIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKI 223 +D VAV NV+S +CF Y + DPE + ++NE + SLVD++PWL+ Sbjct: 123 FLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQY 182 Query: 224 FPNKTLEKLKSHVKIRNDLLNKILEN---YKEKFRSDS-ITNMLDTLMQAKMNSDNGNAG 279 FPN + ++ + N IL+ + E R + +M+D + + G++ Sbjct: 183 FPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSH 242 Query: 280 PDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFS 339 L ++ TI DIFGA +T ++ ++W L P V+ ++ E+DQ VG Sbjct: 243 G--GGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRD 300 Query: 340 RTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWAL 399 R P + D+ L + A + E +R P+ IPH ++S+ + + K T V +N W++ Sbjct: 301 RLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSV 360 Query: 400 HHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWL 459 +H+ +W P+ F P RFL+ G + + F G R CIGE L++ +LFL ++ L Sbjct: 361 NHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISIL 420 Query: 460 LQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWR 500 + D + + + + SFKV + +R++ Sbjct: 421 AHQCDFR-ANPNEPAKMNFSYGLTIKPKSFKVNVTLRESME 460 >3DL9-A nrPDB Length = 479 Score = 394 bits (1011), Expect = e-110, Method: Composition-based stats. Identities = 124/450 (27%), Positives = 228/450 (50%), Gaps = 12/450 (2%) Query: 49 MHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNN 108 H K + YG I+S+ +G +TV++ + + KE L+ + + F+ RP + + Sbjct: 36 PHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMT-K 94 Query: 109 RKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDIS 168 G+ + G W HRRLA+ +F F G + E I +E D + T+ G+ D Sbjct: 95 MGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFK 154 Query: 169 FPVFVAVTNVISLICFNTSYKNGDPELNVI-QNYNEGI-IDNLSKDSLVDLVPWLKIFPN 226 + AV+N+ +LI F + D + + + ++E + + + L + PW+ I P Sbjct: 155 QLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF 214 Query: 227 KTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSEL 286 ++L + + D L++++E + + +D + D + G + S Sbjct: 215 GKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYL------DEMDQGKNDPSST 268 Query: 287 LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD 346 S +++ ++G++ AG ETTT+V++W + F+ P ++ ++ +EID +G + P+ D Sbjct: 269 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 328 Query: 347 RNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW 406 + ++ EA + EVLR + P+ I H + D+ + +++ KGT VI NL+++H +EK W Sbjct: 329 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 388 Query: 407 HQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466 P+ F PERFL+ +G + + +PF G R C+GE LAR E+FL LLQRF L Sbjct: 389 RDPEVFHPERFLDSSG--YFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLH 446 Query: 467 VPDDGQLPSLEGIPKVVFLIDSFKVKIKVR 496 P + +P L+ + + + + R Sbjct: 447 FPHEL-VPDLKPRLGMTLQPQPYLICAERR 475 >3TBG-A nrPDB Length = 479 Score = 384 bits (987), Expect = e-107, Method: Composition-based stats. Identities = 125/482 (25%), Positives = 226/482 (46%), Gaps = 13/482 (2%) Query: 19 KRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGH 78 K+ K P L LP +G+L + + F +L++++G ++S+++ V++ Sbjct: 3 KKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVLNG 61 Query: 79 HQLAKEVLIKKGKDFSGRPQMATLDIASNNR--KGIAFADSGAHWQLHRRLAMATFALFK 136 +E L+ G+D + RP + I +G+ A G W+ RR +++T Sbjct: 62 LAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLG 121 Query: 137 DGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPEL- 195 G + LE+ + +E + LC A H+G+ + + AV+NVI+ + ++ DP Sbjct: 122 LGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFL 181 Query: 196 NVIQNYNEGIIDNLS-KDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKF 254 ++ EG+ + +++ VP L P + L+ L+++L ++ + Sbjct: 182 RLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQ-LDELLTEHRMTW 240 Query: 255 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314 L A+M GN +D ++ + D+F AG+ TT++ + W Sbjct: 241 DPAQPPRDLTEAFLAEMEKAKGNPESS-----FNDENLRIVVADLFSAGMVTTSTTLAWG 295 Query: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHK 374 L ++ +P V++++ +EID +G R P + D+ + A I EV R + P+ + H Sbjct: 296 LLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHM 355 Query: 375 ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLP 434 + D + F + KGT +I NL ++ +E W +P +F PE FL+ G ++LP Sbjct: 356 TSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGH--FVKPEAFLP 413 Query: 435 FGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIK 494 F AG R+C+GE LAR ELFL LLQ F VP PS G+ + +++ Sbjct: 414 FSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAV 473 Query: 495 VR 496 R Sbjct: 474 PR 475 >5YLW-A nrPDB Length = 495 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 122/480 (25%), Positives = 224/480 (46%), Gaps = 32/480 (6%) Query: 4 LVALLLL--TLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYG 61 L AL + T+ +L + +RR P P+VG++ L + H F KL K+YG Sbjct: 7 LAALFFIAATITFLSFRRRRN----LPPGPFPYPIVGNMLQLG--ANPHQVFAKLSKRYG 60 Query: 62 PIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHW 121 P+ S+ +G+ TVIV ++AKE+L + G+ FSGR + +++ + F + W Sbjct: 61 PLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDKISMGFLPVASEW 120 Query: 122 QLHRRLAMATFAL--FKDGDQKLEKIICQEISTLCDML--ATHNGQSIDISFPVFVAVTN 177 + R++ + Q L + Q++ L D + + +G+++DI F+ N Sbjct: 121 RDMRKICKEQMFSNQSMEASQGLRR---QKLQQLLDHVQKCSDSGRAVDIREAAFITTLN 177 Query: 178 VISLICFNTSYKNGDPELNV-IQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEK----- 231 ++S F++ D + + + EG+ + + D P L+ F + +++ Sbjct: 178 LMSATLFSSQATEFDSKATMEFKEIIEGVATIVGVPNFADYFPILRPFDPQGVKRRADVF 237 Query: 232 LKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNH 291 + LN+ LE+ + + + L+ ++ ++ L +H Sbjct: 238 FGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQANEF----------KLKTHH 287 Query: 292 ILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLL 351 + D+F G +T T+ ++W ++ L+ NP +L E+ G + S +L Sbjct: 288 FTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDESAMPKLP 347 Query: 352 LLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQ 411 L+A I+EV+R+ P P+L+P KA D + + + KGT+++IN +A+ + W P+ Sbjct: 348 YLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSIWTDPET 407 Query: 412 FMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDG 471 F PERFL+ LPFG+G R C G LA + L + A L+ FD ++ DD Sbjct: 408 FDPERFLD-NKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNFDWKLEDDS 466 >6DA2-A nrPDB Length = 487 Score = 336 bits (862), Expect = 1e-92, Method: Composition-based stats. Identities = 118/475 (24%), Positives = 201/475 (42%), Gaps = 24/475 (5%) Query: 29 KSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIK 88 LP +G++ H + KKYG ++ G + + + + K VL+K Sbjct: 19 PGPTPLPFLGNILS--YHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVK 76 Query: 89 KGKD-FSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIIC 147 + F+ R + + I+ A+ W+ R L TF K +++ II Sbjct: 77 ECYSVFTNRRPFGPVGFM---KSAISIAED-EEWKRLRSLLSPTFTSGK--LKEMVPIIA 130 Query: 148 QEISTLCDMLA--THNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGI 205 Q L L G+ + + +VI+ F + + + N + E Sbjct: 131 QYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLN---NPQDPFVENT 187 Query: 206 IDNLSKDSLVDLVPWLKIFPN--KTLEKLKSHVKIRN--DLLNKILENYKEKFRSDSITN 261 L D L + +FP LE L V R + L K ++ KE D+ + Sbjct: 188 KKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKH 247 Query: 262 MLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHN 321 +D L ++ D+ N+ + + LSD ++ AG ETT+SV+ + + L + Sbjct: 248 RVDFL---QLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 304 Query: 322 PQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSI 381 P V++KL EEID + PT ++ L+ + E LRL P+A M + D I Sbjct: 305 PDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEI 363 Query: 382 GEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRS 441 + KG V+I +ALH + K W +P++F+PERF + Y PFG+GPR+ Sbjct: 364 NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNI--DPYIYTPFGSGPRN 421 Query: 442 CIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVR 496 CIG A + L + +LQ F + + Q+P + ++ +K++ R Sbjct: 422 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 476 >5VEU-A nrPDB Length = 480 Score = 322 bits (824), Expect = 3e-88, Method: Composition-based stats. Identities = 114/456 (25%), Positives = 198/456 (43%), Gaps = 31/456 (6%) Query: 29 KSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIK 88 LPL+G++ + + KKYG ++ G + + + + VL+K Sbjct: 18 PGPTPLPLLGNVLS--YRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVK 75 Query: 89 KGKD-FSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIIC 147 + F+ R + + + I+ A+ W+ R L TF K +++ II Sbjct: 76 ECYSVFTNRRSLGPVGFM---KSAISLAED-EEWKRIRSLLSPTFTSGK--LKEMFPIIA 129 Query: 148 QEISTLCDMLA--THNGQSIDISFPVFVAVTNVISLICFNTSYKN----GDPELNVIQNY 201 Q L L G+ + + +VI+ F + + DP + + + Sbjct: 130 QYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKF 189 Query: 202 NE-GIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN--DLLNKILENYKEKFRSDS 258 + G +D L ++ P+L E L + ++ + L+K + K+ +D Sbjct: 190 LKFGFLDPLFLSIIL--FPFLT----PVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDK 243 Query: 259 ITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFL 318 + LD L ++ D+ N+ + + LSD + AG ETT+SV+ +TL L Sbjct: 244 QKHRLDFL---QLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL 300 Query: 319 LHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVD 378 +P V++KL +EID + PT ++ L+ + E LRL PVA + + D Sbjct: 301 ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA-IRLERTCKKD 359 Query: 379 SSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAG 438 I + KG+ V+I +ALHH+ K W +P++F PERF + Y PFG G Sbjct: 360 VEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSI---DPYIYTPFGTG 416 Query: 439 PRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLP 474 PR+CIG A + L + +LQ F + + Q+P Sbjct: 417 PRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 452 >3K9V-A nrPDB Length = 482 Score = 293 bits (751), Expect = 9e-80, Method: Composition-based stats. Identities = 101/464 (21%), Positives = 202/464 (43%), Gaps = 40/464 (8%) Query: 29 KSLLSLPLVGSLPFLPRHGHM---HNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEV 85 + PL+GSL + G + H+ + KKYG I+ +++G+ +V +G L E Sbjct: 27 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLL-EA 85 Query: 86 LIKKGKDFSGRPQMATLDIASNNR---KGIAFADSGAHWQLHR----RLAMATFALFKDG 138 L + R ++ ++R G+ + G WQ R + M + K Sbjct: 86 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILE-GQEWQRVRSAFQKKLMKPVEIMKL- 143 Query: 139 DQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVI 198 D+K+ +++ + + D L G+ D+ + I L+ + + Sbjct: 144 DKKINEVLADFLERM-DELCDERGRIPDLYSELNKWSFESICLVLYEKRF---------- 192 Query: 199 QNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDS 258 G++ +++ + + +K + + + + V++ L K+ + + + D+ Sbjct: 193 -----GLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAW--DT 245 Query: 259 ITNMLDTLMQAKMNSDNGNAGPD-----QDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313 I + + ++ + G D + LS + + ++ A VETT + + W Sbjct: 246 IFKSVKPCIDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMW 305 Query: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 373 L L NPQ +++L +E+ + ++TP D + L+A ++E +RL P P Sbjct: 306 ILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF-TTR 364 Query: 374 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYL 433 + + +GE+A+ KGT + +N L +E + +F PER+L ++L Sbjct: 365 TLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKIN---PFAHL 421 Query: 434 PFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLE 477 PFG G R CIG LA +L L + W++Q++D+ D+ + L Sbjct: 422 PFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLH 465 >3EL3-A nrPDB Length = 467 Score = 292 bits (748), Expect = 2e-79, Method: Composition-based stats. Identities = 94/453 (20%), Positives = 182/453 (40%), Gaps = 30/453 (6%) Query: 18 PKRRCPGAKYPKSLLSLPLVGS-LPFLPRHGHMHN---NFFKLQKKYGPIYSVRMGTKTT 73 P+ R P A L P+ G +P L + F + +G + +++G KT Sbjct: 8 PETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTV 67 Query: 74 VIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFA 133 V + +L + + +G P +L+ ++G+A A+ H + RR F Sbjct: 68 YAVTNPELTGALALNPDYHIAG-PLWESLEGLL-GKEGVATANGPLH-RRQRRTIQPAFR 124 Query: 134 LFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDP 193 L D I+ +E L + G+++D + F V + Y + Sbjct: 125 L--DAIPAYGPIMEEEAHALTERW--QPGKTVDATSESFRVAVRVAARCLLRGQYMDERA 180 Query: 194 ELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK 253 E + + + + +V L P + P + + + L+++I+ + Sbjct: 181 ERLCVALAT--VFRGMYRRMVVPLGPLYR-LPLPANRRFNDALADLHLLVDEIIAERRAS 237 Query: 254 FRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313 + ++L L++AK D + + + + I + I G ET S + W Sbjct: 238 GQK--PDDLLTALLEAK----------DDNGDPIGEQEIHDQVVAILTPGSETIASTIMW 285 Query: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 373 L L +P+ ++ +E++ G R D +L I E +RLRP +L Sbjct: 286 LLQALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVL-TR 343 Query: 374 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYL 433 +A +S +G + + G ++I + +A+ + K + +F P+R+L + P + Sbjct: 344 RAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANV--PKYAMK 401 Query: 434 PFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466 PF AG R C + + +L LI A L ++ E Sbjct: 402 PFSAGKRKCPSDHFSMAQLTLITAALATKYRFE 434 >3MDV-A nrPDB Length = 456 Score = 278 bits (711), Expect = 4e-75, Method: Composition-based stats. Identities = 89/431 (20%), Positives = 175/431 (40%), Gaps = 28/431 (6%) Query: 49 MHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNN 108 + + F KKYGP+ V + KT+VIV + K+ L+ + + A + Sbjct: 12 LQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGER 71 Query: 109 RKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLA-THNGQ-SID 166 G + + H++ + A + L + ++ L ++L +GQ + Sbjct: 72 LFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVS 131 Query: 167 ISFPVFVAVTNVISLICFNTSYK----NGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLK 222 + + ++++ F P ++ EGI S+++L +P + Sbjct: 132 MQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGI--TASRNTLAKFLPGKR 189 Query: 223 IFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQ 282 + E ++ ++ D + + E K + ++L +++A+ + + Sbjct: 190 KQLREVRESIRFLRQVGRDWVQRRREALK--RGEEVPADILTQILKAEEGAQD------- 240 Query: 283 DSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTP 342 D +L F AG ET+ + + +T+ L P++ +L E+D+ +G R Sbjct: 241 ------DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYL 294 Query: 343 TISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHN 402 D RL L ++E LRL P A ++ I V T ++ + + + Sbjct: 295 DFEDLGRLQYLSQVLKESLRLYPPA-WGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRM 353 Query: 403 EKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 + + P F P+RF G P +Y PF G RSCIG+ A+ E+ ++MA LLQR Sbjct: 354 DTYFEDPLTFNPDRF----GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR 409 Query: 463 FDLEVPDDGQL 473 + + + Sbjct: 410 LEFRLVPGQRF 420 >6CR2-A nrPDB Length = 477 Score = 274 bits (700), Expect = 7e-74, Method: Composition-based stats. Identities = 91/474 (19%), Positives = 171/474 (36%), Gaps = 44/474 (9%) Query: 26 KYPKSLLSL-PLVGSLPFLPRHGHMHNNFFKLQKKYGPIYS-VRMGTKTTVIVGHHQLAK 83 K P + P +GS + + FF + KYG I++ + +G KTTV + + Sbjct: 4 KTPPVVFHWFPFIGS--TISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYL-GTKGND 60 Query: 84 EVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLE 143 +L K +D + L R + + +L + + L D + Sbjct: 61 FILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNA---KLMEQKKFVKYGLTSDALRSYV 117 Query: 144 KIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNE 203 +I E+ + G VF + + + S E +++ + Sbjct: 118 PLITDEVESFVKNSPAFQGHK-----GVFDVCKTIAEITIYTASRSLQGKE---VRSKFD 169 Query: 204 GIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNML 263 L + + P + P L + + L +E K + ++ S + Sbjct: 170 STFAELYHNLDMGFAPINFMLPWAPLPHNRKRDAAQRKLTETYMEIIKARRQAGSKKDSE 229 Query: 264 DTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQ 323 D + + ++ + D I + + AG +++S W + L P Sbjct: 230 DMVWNLM-------SCVYKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPD 282 Query: 324 VKKKLYEEIDQNVGFSRTP-TISDRNRLLLLEATIREVLRLR-PVAPMLIPHKANVDSSI 381 + ++LY+E + +G P T + +L L I+E LRL P+ ++ K + Sbjct: 283 IMEELYQEQIRVLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDG 342 Query: 382 GEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA--------------GTQLIS 427 + + V+ + +E+ + P ++ P R+ G Sbjct: 343 TSYVIPTSHNVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVDYGYGLVSKG 402 Query: 428 PSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPK 481 + YLPFGAG CIGE A +L I A L++ F LP ++GIP Sbjct: 403 TNSPYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFRFR-----NLPGVDGIPD 451 >2VE3-A nrPDB Length = 444 Score = 270 bits (690), Expect = 9e-73, Method: Composition-based stats. Identities = 94/455 (20%), Positives = 173/455 (38%), Gaps = 39/455 (8%) Query: 20 RRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHH 79 P LP +G G K Q+++GPI+ R+ K + + Sbjct: 6 TNLNSLPIPPGDFGLPWLGETLNFLNDGDFGK---KRQQQFGPIFKTRLFGKNVIFISGA 62 Query: 80 QLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGD 139 + + K+ + F ++T + N A A RR + L + D Sbjct: 63 LANRFLFTKEQETFQATWPLSTRILLGPN----ALATQMGEIHRSRRKILYQAFLPRTLD 118 Query: 140 QKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE-LNVI 198 L K+ + L + I +P +T ++ F + +P+ Sbjct: 119 SYLPKMD----GIVQGYLEQWGKANEVIWYPQLRRMTFDVAATLFMGEKVSQNPQLFPWF 174 Query: 199 QNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDS 258 + Y +G+ PN K + + L KI++ +++ S+ Sbjct: 175 ETYIQGLFSLPI------------PLPNTLFGKSQRARALLLAELEKIIKARQQQPPSE- 221 Query: 259 ITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFL 318 + L L+ A+ D +++ LS + I + AG ET TS + L Sbjct: 222 -EDALGILLAAR----------DDNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLL 270 Query: 319 LHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVD 378 + +++++ +E + + S+ T ++ L+ ++EVLRL P + D Sbjct: 271 GQHSDIRERVRQEQN-KLQLSQELTAETLKKMPYLDQVLQEVLRLIPPV-GGGFRELIQD 328 Query: 379 SSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAG 438 F KG V + H + + P++F PERF P G+ +P +++PFG G Sbjct: 329 CQFQGFHFPKGWLVSYQISQTHADPDLYPDPEKFDPERF-TPDGSATHNPPFAHVPFGGG 387 Query: 439 PRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQL 473 R C+G+ AR E+ L L+Q+FD + L Sbjct: 388 LRECLGKEFARLEMKLFATRLIQQFDWTLLPGQNL 422 >6AYB-A nrPDB Length = 466 Score = 258 bits (658), Expect = 5e-69, Method: Composition-based stats. Identities = 96/484 (19%), Positives = 183/484 (37%), Gaps = 31/484 (6%) Query: 19 KRRCPGAKYPKS-LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVG 77 K+ K P +P VGS F+ + KKYG +++ + K + Sbjct: 3 KKTSSKGKLPPRVPNLIPYVGS--FVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFLN 60 Query: 78 HHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKD 137 H ++ + S R + + ADS + + + Sbjct: 61 HPKILDTFFKATDNELSLR-DVYRFMRPVFGTGVVYDADSTERMMEQVKFVSSGLTTARF 119 Query: 138 GDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNV 197 + I EI+ L ++D++ + + S D Sbjct: 120 --RVFVDIFEDEIAHKVKELGPEG--TVDVAELMADLIIFTASRCLLG------DEVRQY 169 Query: 198 IQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHV-KIRNDLLNKILENYK---EK 253 + N G + + D + L + P +K + V +I +LL+K E +K E+ Sbjct: 170 LSEKNLGKLYHDIDDGISPLSFFYPSLPAPKRDKARKAVGEIFQELLDKRREEHKKHPER 229 Query: 254 FRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313 +S +++D L+ K +D + L+D H + + AG T++ W Sbjct: 230 LLDESKMDVVDHLLTQKY----------KDGQELTDVHRIGILIAGLFAGQHTSSITSSW 279 Query: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 373 TL ++ N +V +K+ +E ++ +G + ++ LEA ++E LR+ P ++I Sbjct: 280 TLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPL-IMIMR 338 Query: 374 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYL 433 A ++ + KG ++++ + PD F PER + + Sbjct: 339 MARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGA--V 396 Query: 434 PFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKI 493 PFGAG CIGE A ++ I++ LL+ FD+E PS + + K+ Sbjct: 397 PFGAGRHKCIGENFALLQVKSIISILLRYFDMEYIGKIPDPSYTSLVVGPSPPTRMRYKL 456 Query: 494 KVRQ 497 + +Q Sbjct: 457 RKQQ 460 >4WMZ-A nrPDB Length = 539 Score = 257 bits (657), Expect = 7e-69, Method: Composition-based stats. Identities = 99/499 (19%), Positives = 179/499 (35%), Gaps = 48/499 (9%) Query: 28 PKSLLSL-PLVGSLPFLPRHGHMHNNFFKLQKKYGPIYS-VRMGTKTTVIVGHHQLAKEV 85 P + P VGS + F + QKKYG I+S V +G TV + + + V Sbjct: 56 PPLVFYWIPWVGSAVVYGMK--PYEFFEECQKKYGDIFSFVLLGRVMTVYL-GPKGHEFV 112 Query: 86 LIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKI 145 K D S A L + I + +L + AL K+ + + Sbjct: 113 FNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNS---RLMEQKKFVKGALTKEAFKSYVPL 169 Query: 146 ICQEISTLCDMLATHNG-QSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEG 204 I +E+ + + + + + F S E ++ + Sbjct: 170 IAEEVY---KYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKE---MRAKLDT 223 Query: 205 IIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSI--TNM 262 L D P +FPN LE + + + + KE+ +++ I ++ Sbjct: 224 DFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDL 283 Query: 263 LDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNP 322 +D+LM+ +D ++D I + + G T+ + W L L P Sbjct: 284 IDSLMK---------NSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERP 334 Query: 323 QVKKKLYEEIDQNV-GFSRTPTISDRNRLLLLEATIREVLRL-RPVAPMLIPHKANVDSS 380 V+++LYEE + + G + T + LL TI+E LR+ P+ + ++ Sbjct: 335 DVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVP 394 Query: 381 IGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA--------------GTQLI 426 + + G V+++ H ++ + QF R+ N + G Sbjct: 395 NTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISK 454 Query: 427 SPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLI 486 S YLPFG G CIGE A +L ++M+ ++ P+ +P + V Sbjct: 455 GVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMVTLPT 514 Query: 487 DSFKVKIKVRQAWREAQAE 505 K+ W + E Sbjct: 515 GPAKII------WEKRNPE 527 >3S79-A nrPDB Length = 503 Score = 255 bits (650), Expect = 4e-68, Method: Composition-based stats. Identities = 103/478 (21%), Positives = 193/478 (40%), Gaps = 35/478 (7%) Query: 17 WPKRRCPGAKYPKSLLSL-PLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVI 75 W P + + PL+ FL N+ + YG V + + T+I Sbjct: 39 WNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNY--YNRVYGEFMRVWISGEETLI 96 Query: 76 VGHHQLAKEVLIKKGKDFSGR-PQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFAL 134 + + + I K +S R L + KGI F ++ W+ R M AL Sbjct: 97 IS--KSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMK--AL 152 Query: 135 FKDGDQKLEKIICQEISTLCDMLATHNGQS--IDISFPVFVAVTNVISLICFNTSYKNGD 192 G ++ + + + T D L +S +D+ + + + S F + Sbjct: 153 SGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLD-TSNTLFLRIPLDES 211 Query: 193 PELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKE 252 + IQ Y + L K + + WL K+++ LK +++ I E + Sbjct: 212 AIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVL------IAEKRRR 265 Query: 253 KFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVK 312 + + +D + + G+ L+ ++ I ++ A +T + + Sbjct: 266 ISTEEKLEECMDFATELILAEKRGD---------LTRENVNQCILEMLIAAPDTMSVSLF 316 Query: 313 WTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIP 372 + L + +P V++ + +EI +G R I D +L ++E I E +R +PV +++ Sbjct: 317 FMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDLVM- 374 Query: 373 HKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSY 432 KA D I + V KGT +I+N+ +H E + +P++F E F P + Sbjct: 375 RKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAK------NVPYRYF 427 Query: 433 LPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFK 490 PFG GPR C G+ +A + I+ LL+RF ++ + S++ I + D K Sbjct: 428 QPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETK 485 >5JLC-A nrPDB Length = 515 Score = 253 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 98/499 (19%), Positives = 179/499 (35%), Gaps = 46/499 (9%) Query: 28 PKSLLSL-PLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVL 86 P + P VGS +P + F QKKYG I+S + + + + + + Sbjct: 38 PPLVFYWIPWVGS--AIPYGTKPYEFFEDCQKKYGDIFSFMLLGRIMTVYLGPKGHEFIF 95 Query: 87 IKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKII 146 K D S + L + I + +L + AL K+ + +I Sbjct: 96 NAKLADVSAEAAYSHLTTPVFGKGVIYDCPNH---RLMEQKKFVKGALTKEAFVRYVPLI 152 Query: 147 CQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGII 206 +EI + + + + + + + F S E +++ + Sbjct: 153 AEEIYKYFRNSKNF--KINENNSGIVDVMVSQPEMTIFTASRSLLGKE---MRDKLDTDF 207 Query: 207 DNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSI--TNMLD 264 L D P +FPN LE + + + + KE+ + I +++D Sbjct: 208 AYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQQAISGTYMSLIKERREKNDIQNRDLID 267 Query: 265 TLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQV 324 LM+ +D ++D I + + G T+ + W L L P V Sbjct: 268 ELMK---------NSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDV 318 Query: 325 KKKLYEEIDQNVGFS-RTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGE 383 +++LY+E + + + T D + LL I+E LRL L K D +I Sbjct: 319 QEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSL-FRKVMRDVAIPN 377 Query: 384 --FAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA---------------GTQLI 426 + V + V+++ H E+ + +P++F R+ A G Sbjct: 378 TSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISK 437 Query: 427 SPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLI 486 S YLPFG G CIGE+ A +L ++M+ ++ P +G+ +V L Sbjct: 438 GVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTEGETVPPSDFTSMVTLP 497 Query: 487 DSFKVKIKVRQAWREAQAE 505 + W + E Sbjct: 498 -----TAPAKIYWEKRHPE 511 >3MZS-A nrPDB Length = 486 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 98/479 (20%), Positives = 186/479 (38%), Gaps = 42/479 (8%) Query: 22 CPGAKYPKSLLSLPLVGSLPFLPRHGH------MHNNFFKLQKKYGPIYSVRMGTKTTVI 75 P S + P L +H + +KYGPIY ++G +V Sbjct: 3 STKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVY 62 Query: 76 VGHHQLAKEVLIKKGKDFSGR---PQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATF 132 + H + + +G + R P G+ F SG W+ R+ + T Sbjct: 63 IIHPEDVAHLFKFEG-SYPERYDIPPWLAYHRYYQKPIGVLFKKSGT-WK-KDRVVLNTE 119 Query: 133 ALFKDGDQKLEKI---ICQEISTLCDMLATHNGQ-------SIDISFPVFVAVTNVISLI 182 + + + + + Q+ +L G D+ F ++TNV+ Sbjct: 120 VMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGE 179 Query: 183 CFNTSYKNGDPELNVIQNYNEGIIDNLSKD-SLVDLVPWL-KIFPNKTLEKLKSHVKIRN 240 + +PE Q + + + L+++ P L ++F KT + HV + Sbjct: 180 RLGMLEETVNPEA---QKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTW---RDHVAAWD 233 Query: 241 DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF 300 + NK E Y E F D + + + G SE + + I ++ Sbjct: 234 TIFNKA-EKYTEIFYQDLRR-------KTEFRNYPGILYCLLKSEKMLLEDVKANITEML 285 Query: 301 GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV 360 GV TT+ ++W L + + V++ L EE+ + + LL+A+I+E Sbjct: 286 AGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKET 345 Query: 361 LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420 LRL P++ L D + ++ + T V + ++A+ + + PD+F P R+L+ Sbjct: 346 LRLHPISVTLQ-RYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSK 404 Query: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGI 479 + L FG G R C+G +A E+ L + +L+ F +E+ G + ++ + Sbjct: 405 DKDLIH---FRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNL 460 >6C94-A nrPDB Length = 497 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 100/501 (19%), Positives = 189/501 (37%), Gaps = 55/501 (10%) Query: 29 KSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIK 88 + L G + + G + +++ + + +G + ++ Sbjct: 25 PGPPTHWLFGHALEIQKTGSLDKVVT-WTQQFPYAHPLWVGQF-IGFLNIYEP------D 76 Query: 89 KGKDFSGRPQMATLDIASN----NRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEK 144 K R D+ KG+ D G W HR+L F D + Sbjct: 77 YAKAVYSRGDPKAPDVYDFFLQWIGKGLLVLD-GPKWFQHRKLLTPGFHY--DVLKPYVA 133 Query: 145 IICQEISTLCDMLAT--HNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYN 202 I + + G+S DI F V ++ ++ GD LN + Sbjct: 134 IFADSTRIMLEKWEKKACEGKSFDI----FSDVGHMALDTLMKCTFGKGDSGLNHRDSSY 189 Query: 203 EGIIDNLSK------DSLV---DLVPWLKIFPNKTLEKLKSHVKIRNDLLNKIL-----E 248 + L+ DS D + WL + L ++ + ++ + E Sbjct: 190 YVAVSELTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACRAAHDHTDRVIRQRKAALQDE 249 Query: 249 NYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTT 308 +EK ++ + LD L+ + + LSD + + G +TTT Sbjct: 250 KEREKIQNRRHLDFLDILLDVR----------GESGVQLSDTDLRAEVDTFMFEGHDTTT 299 Query: 309 SVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAP 368 S + W L + P+ +++ EE+ + +G + D ++ L ++E RL P P Sbjct: 300 SGISWFLYCMALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVP 359 Query: 369 MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISP 428 + + S + ++ G+ + ++++ALH N W P+ F P RF + Sbjct: 360 QVYRQLSKPVSFVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRH-- 417 Query: 429 SVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDS 488 +++PF AGPR+CIG+ A E+ ++ A L RF+ V D +LP +P++V + Sbjct: 418 PYAFIPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSV-DPLRLPI--KLPQLVLRSKN 474 Query: 489 -FKVKIKVRQAWREAQAEGST 508 + +K +AE ST Sbjct: 475 GIHLYLKPLG----PKAEKST 491 >5FSA-A nrPDB Length = 490 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 98/501 (19%), Positives = 173/501 (34%), Gaps = 49/501 (9%) Query: 26 KYPKSLLSL-PLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKE 84 K P + P GS + + F ++KYG ++S + K + + + Sbjct: 4 KTPPLVFYWIPWFGSAASYGQ--QPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEF 61 Query: 85 VLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEK 144 V K D S L I + +L + A FAL D ++ Sbjct: 62 VFNAKLSDVSAEEAYKHLTTPVFGTGVIYDCPNS---RLMEQKKFAKFALTTDSFKRYVP 118 Query: 145 IICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEG 204 I +EI L + + + + + V + + F S E ++ + Sbjct: 119 KIREEI--LNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDE---MRRIFDR 173 Query: 205 IIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILEN---YKEKFRSDSITN 261 L D P +FPN L + + ++ +E+ D + Sbjct: 174 SFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKLRRERGDIDPNRD 233 Query: 262 MLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHN 321 ++D+L+ +D ++D I + I G T+ S W L L Sbjct: 234 LIDSLLIH---------STYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEK 284 Query: 322 PQVKKKLYEEI----DQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANV 377 P ++ +Y+E+ + G T D +L + TI+E LR+ I K Sbjct: 285 PHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHS-IFRKVTN 343 Query: 378 DSSI--GEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA-------------- 421 I + V KG V+++ H +E+ + P+ F P R+ A Sbjct: 344 PLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEV 403 Query: 422 ----GTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLE 477 G S YLPFG G CIGE A +L I+ + + D ++P + Sbjct: 404 DYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTI-DGYKVPDPD 462 Query: 478 GIPKVVFLIDSFKVKIKVRQA 498 VV + ++ + R+ Sbjct: 463 YSSMVVLPTEPAEIIWEKRET 483 >2WX2-A nrPDB Length = 473 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 85/458 (18%), Positives = 166/458 (36%), Gaps = 48/458 (10%) Query: 28 PKSLLSLPLVGSLPFLPRHGHMHNNFFKLQK---KYGPIYSVRMGTKTTVIVGHHQLAKE 84 P +++P +G + ++ F + K K G ++++ +G + IVG Sbjct: 19 PVYPVTVPFLGHIVQFGKNP---LEFMQRCKRDLKSG-VFTISIGGQRVTIVGDPHEHSR 74 Query: 85 VLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEK 144 + + S R + +G+A+A + + K Q Sbjct: 75 FFSPRNEILSPREVYTIMTPVF--GEGVAYAAPYPRMREQLNFLAEELTIAKF--QNFVP 130 Query: 145 IICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNT--SYKNGDPELNVIQNYN 202 I E+ + I++ + N F + + + Sbjct: 131 AIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKM 190 Query: 203 EGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKIL--ENYKEKFRSDSIT 260 E S +PWL P + + +L +I+ +E + ++ + Sbjct: 191 ES-----SLIPAAVFMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNTS 245 Query: 261 NMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLH 320 ++L L++A +D +S + + I AG T+T W++ L+H Sbjct: 246 DLLGGLLKAVY----------RDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMH 295 Query: 321 --NPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVD 378 N + KL++EID+ + D + E +RE +R P M++ + Sbjct: 296 PKNKKWLDKLHKEIDEFPAQLNYDNVMD--EMPFAERCVRESIRRDPPLLMVM-RMVKAE 352 Query: 379 SSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAG 438 +G + V KG + + HH+E+ + P + PER G +++ FGAG Sbjct: 353 VKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDG--------AFIGFGAG 404 Query: 439 PRSCIGEILARQELFLIMAWLLQRFDL-----EVPDDG 471 CIG+ A ++ I+A + +D EVPD Sbjct: 405 VHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPD 442 >3L4D-A nrPDB Length = 453 Score = 233 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 86/479 (17%), Positives = 172/479 (35%), Gaps = 43/479 (8%) Query: 24 GAKYPKSLLSL-PLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLA 82 K P + P VG + + K +KKYG I+++ + +VG Sbjct: 1 KGKLPPVVHGTTPFVGHIIQFGKD--PLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQH 58 Query: 83 KEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKL 142 + + + S R + + +G+A+A + + K Q Sbjct: 59 SKFFTPRNEILSPREVYSFMVPVF--GEGVAYAAPYPRMREQLNFLAEELTVAKF--QNF 114 Query: 143 EKIICQEISTLCD-MLATHNGQSIDISFPVFVAVTNVISLICFNT--SYKNGDPELNVIQ 199 I E+ G+ I+I + N F + + + Sbjct: 115 APSIQHEVRKFMKANWNKDEGE-INILDDCSAMIINTACQCLFGEDLRKRLDARQFAQLL 173 Query: 200 NYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKIL--ENYKEKFRSD 257 E + +PW+ P + + D+L++I+ +E + Sbjct: 174 AKMESCL-----IPAAVFLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEEAQKDT 228 Query: 258 SITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAF 317 + +++L L+ A +D +S + + I AG T+T W+L Sbjct: 229 NTSDLLAGLLGAVY----------RDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLH 278 Query: 318 LL--HNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKA 375 L+ N + KL++EID+ + + + E RE +R P ML+ K Sbjct: 279 LMDPRNKRHLAKLHQEIDEFPAQLNYDNVME--EMPFAEQCARESIRRDPPLVMLM-RKV 335 Query: 376 NVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPF 435 +G++ V +G + + H +E+ + P ++ PER + ++ F Sbjct: 336 LKPVQVGKYVVPEGDIIACSPLLSHQDEEAFPNPREWNPER-------NMKLVDGAFCGF 388 Query: 436 GAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIK 494 GAG CIGE ++ ++A +L+ +D E+ P+ +V + + ++K Sbjct: 389 GAGVHKCIGEKFGLLQVKTVLATVLRDYDFELLGPLPEPNYHT---MVVGPTASQCRVK 444 >3JUS-A nrPDB Length = 461 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 95/484 (19%), Positives = 190/484 (39%), Gaps = 35/484 (7%) Query: 19 KRRCPGA-KYPKSLL-SLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIV 76 K+ P K P + +P +G + +KYGP++S M KT + Sbjct: 3 KKTLPAGVKSPPYIFSPIPFLGHAIAFGK--SPIEFLENAYEKYGPVFSFTMVGKTFTYL 60 Query: 77 GHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFK 136 A + K +D + + L KG+A+ + +++ + + Sbjct: 61 LGSDAAALLFNSKNEDLNAEDVYSRLTTPVFG-KGVAYDVPNPVFLEQKKMLKSGLNIAH 119 Query: 137 DGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNG-DPEL 195 ++ II +E + +++ F A++ +I L + + +L Sbjct: 120 F--KQHVSIIEKETKEYFESWGESGEKNV------FEALSELIILTASHCLHGKEIRSQL 171 Query: 196 NVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255 N +D + L WL P + + + D+ K ++ ++ Sbjct: 172 NEKVAQLYADLDGGFSHAAWLLPGWL---PLPSFRRRDRAHREIKDIFYKAIQKRRQS-- 226 Query: 256 SDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTL 315 + I ++L TL+ A +D L+D+ + + + AG T+++ W Sbjct: 227 QEKIDDILQTLLDATY----------KDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMG 276 Query: 316 AFLLHNPQVKKKLYEEIDQNVGFSRTP-TISDRNRLLLLEATIREVLRLRPVAPMLIPHK 374 FL + ++KK Y E G + P T L LL+ I+E LRLRP M++ Sbjct: 277 FFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPI-MIMMRM 335 Query: 375 ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLP 434 A ++ + + G +V ++ + W + F P+R+L +Y+P Sbjct: 336 ARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEK--FAYVP 393 Query: 435 FGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIK 494 FGAG CIGE A ++ I + +L+ ++ ++ DG P++ ++ ++ ++ K Sbjct: 394 FGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL-IDGYFPTVN-YTTMIHTPENPVIRYK 451 Query: 495 VRQA 498 R Sbjct: 452 RRST 455 >3N9Z-A nrPDB Length = 487 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 89/495 (17%), Positives = 179/495 (36%), Gaps = 51/495 (10%) Query: 22 CPGAKYPKSLLSLPLVGSLPFLPRHGH------MHNNFFKLQKKYGPIYSVRMGTKTTVI 75 + P + + P L +H + + +KYGPIY ++G +V Sbjct: 1 STRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVY 60 Query: 76 VGHHQLAKEVLIKKGKDFSGR---PQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATF 132 V + + +G + R P G+ S W+ R+A+ Sbjct: 61 VIDPEDVALLFKSEGPN-PERFLIPPWVAYHQYYQRPIGVLLKKSA-AWK-KDRVALNQE 117 Query: 133 ALFKDGDQKLEKI---ICQEISTLCDMLATHNGQ---SIDISFPVFVAVTNVISLICFNT 186 + + + + + ++ ++ G S DIS +F I+ + F Sbjct: 118 VMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGE 177 Query: 187 SYKNGDPELN-VIQNYNEGIIDNLSKDSLVDLVP--WLKIFPNKTLEKLKSHVKIRNDLL 243 + +N Q + + I + +P ++F KT K HV + + Sbjct: 178 RQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTW---KDHVAAWDVIF 234 Query: 244 NK--------ILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTT 295 +K E ++ +L L+ +S I Sbjct: 235 SKADIYTQNFYWELRQKGSVHHDYRGILYRLL---------------GDSKMSFEDIKAN 279 Query: 296 IGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEA 355 + ++ GV+TT+ ++W L + N +V+ L E+ ++ + + LL+A Sbjct: 280 VTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKA 339 Query: 356 TIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPE 415 +I+E LRL P++ L D + ++ + T V + ++AL + P+ F P Sbjct: 340 SIKETLRLHPISVTLQ-RYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPT 398 Query: 416 RFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPS 475 R+L+ L FG G R C+G +A E+ + + +L+ F +E+ + + Sbjct: 399 RWLSKDKNIT---YFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGT 455 Query: 476 LEGIPKVVFLIDSFK 490 + + SF Sbjct: 456 TFNLILMPEKPISFT 470 >2W0A-A nrPDB Length = 455 Score = 218 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 76/443 (17%), Positives = 165/443 (37%), Gaps = 27/443 (6%) Query: 55 KLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAF 114 +++ + G + + ++ K V++ E + G D + + + Sbjct: 32 RVRDELGDVGTFQLAGKQVVLLSGSHAN-EFFFRAGDDDLDQAKAYPFMTPIFGEAVVFD 90 Query: 115 ADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVA 174 A R+ + AL + + I ++ + ID+ Sbjct: 91 ASP-----ERRKEMLHNAALRGEQMKGHAATIEDQVRRMIADWGEAG--EIDLLDFFAEL 143 Query: 175 VTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKS 234 S +++ + + Y+E D L + P+L I + ++ ++ Sbjct: 144 TIYTSSACLIGKKFRDQ-LDGRFAKLYHE---LERGTDPLAYVDPYLPIESFRRRDEARN 199 Query: 235 H-VKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHIL 293 V + D++N + N +MLD L+ K + S + I Sbjct: 200 GLVALVADIMNGRIANPPTDKSD---RDMLDVLIAVKAETGTP---------RFSADEIT 247 Query: 294 TTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLL 353 + AG T++ WTL L+ + + +E+D+ G R+ + ++ L Sbjct: 248 GMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQL 307 Query: 354 EATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFM 413 E ++E LRL P +++ A + + + +G V + + +++ P F+ Sbjct: 308 ENVLKETLRLHPPL-IILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFV 366 Query: 414 PERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQL 473 P R+ P L++ +++PFGAG C+G A ++ I + LL+ ++ E+ + Sbjct: 367 PARYEQPRQEDLLN-RWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPES 425 Query: 474 PSLEGIPKVVFLIDSFKVKIKVR 496 + VV L V+ + R Sbjct: 426 YRNDHSKMVVQLAQPAAVRYRRR 448 >4KPA-A nrPDB Length = 494 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 100/478 (20%), Positives = 193/478 (40%), Gaps = 40/478 (8%) Query: 29 KSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIK 88 + + +LP L + K+ + G I+ + T + +L KE Sbjct: 30 PQPKTFGELKNLPLLNTDKPVQ-ALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEAC-- 86 Query: 89 KGKDFSGRPQMATLDIASNNRKGIAFA-DSGAHWQLHRRLAMATFALFKDGDQKLEKIIC 147 F A + G+ + +W+ + + +F + + ++ Sbjct: 87 DESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSF--SQQAMKGYHAMMV 144 Query: 148 QEISTLCDMLATHNG-QSIDISFPVFVAVTNVISLICFNTSYKNG-----DPELNVIQNY 201 L N + I++ + + I L FN + + P + + Sbjct: 145 DIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRA 204 Query: 202 NEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITN 261 + ++ L + + D ++ + + +K+ NDL++KI+ + K + + Sbjct: 205 LDEAMNKLQRANPDD------PAYDENKRQFQEDIKVMNDLVDKIIADRKASG--EQSDD 256 Query: 262 MLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHN 321 +L ++ N + E L D +I I AG ETT+ ++ + L FL+ N Sbjct: 257 LLTHML---------NGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKN 307 Query: 322 PQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSI 381 P V +K EE + + P+ +L + + E LRL P AP A D+ + Sbjct: 308 PHVLQKAAEEAARVL-VDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSL-YAKEDTVL 365 Query: 382 GE-FAVDKGTEVIINLWALHHNEKEW-HQPDQFMPERFLNPAGTQLISPSVSYLPFGAGP 439 G + ++KG E+++ + LH ++ W ++F PERF NP+ P ++ PFG G Sbjct: 366 GGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAI----PQHAFKPFGNGQ 421 Query: 440 RSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQ 497 R+CIG+ A E L++ +L+ FD E + +L E + + F VK K ++ Sbjct: 422 RACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETL---TLKPEGFVVKAKSKK 476 >2X2N-A nrPDB Length = 475 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 86/456 (18%), Positives = 163/456 (35%), Gaps = 44/456 (9%) Query: 28 PKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLI 87 P +++P++G + + K Q K G I+++ + K IVG + Sbjct: 19 PVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSG-IFTINIVGKRVTIVGDPHEHSRFFL 77 Query: 88 KKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIIC 147 + + S R + + +G+A+A + + K Q I Sbjct: 78 PRNEVLSPREVYSFMVPVF--GEGVAYAAPYPRMREQLNFLAEELTIAKF--QNFVPAIQ 133 Query: 148 QEIS-TLCDMLATHNGQSIDISFPVFVAVTNVISLICFNT--SYKNGDPELNVIQNYNEG 204 E+ + G+ I++ + N F + + E Sbjct: 134 HEVRKFMAANWDKDEGE-INLLEDCSTMIINTACQCLFGEDLRKRLDARRFAQLLAKMES 192 Query: 205 IIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKF--RSDSITNM 262 S +P L P + +L++I+ K + S +++ Sbjct: 193 -----SLIPAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKAAAVNKDSSTSDL 247 Query: 263 LDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLH-- 320 L L+ A +D +S + + I AG T++ W++ L+H Sbjct: 248 LSGLLSAVY----------RDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPA 297 Query: 321 NPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSS 380 N + + L +EI++ + D + E RE +R P ML+ K D Sbjct: 298 NVKHLEALRKEIEEFPAQLNYNNVMD--EMPFAERCARESIRRDPPLLMLM-RKVMADVK 354 Query: 381 IGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPR 440 +G + V KG + + HH+E+ + +P ++ PER G +++ FGAG Sbjct: 355 VGSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPERDEKVEG--------AFIGFGAGVH 406 Query: 441 SCIGEILARQELFLIMAWLLQRFDL-----EVPDDG 471 CIG+ ++ I+A + +D EVPD Sbjct: 407 KCIGQKFGLLQVKTILATAFRSYDFQLLRDEVPDPD 442 >4GGV-A nrPDB Length = 418 Score = 199 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 78/413 (18%), Positives = 153/413 (37%), Gaps = 67/413 (16%) Query: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALF 135 V + A ++L S + + + + +G + +R+L F Sbjct: 58 VYGYPEAMDILNDHDTFTSDLAHLLPVSVDAPLLEGDMSQMDPPRHRKYRQLVSRAFT-- 115 Query: 136 KDGDQKLEKIICQEISTLCDMLATHNGQS-----IDISFPVFVAVTNVISLICFNTSYKN 190 +E + L D + +G+ D+++P+ V V I Sbjct: 116 PRLVADMETRVADITRELLDAV---DGKPEIEIAADLAYPLPVIV------IAELLGVPA 166 Query: 191 GDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENY 250 GD +L + + + II+ S S +D + + ++ + LL+ + + Sbjct: 167 GDRDL--FKKWADDIIEGFSGFSFLDTS-------GQGEQDVRDATERLRPLLDYMAGHV 217 Query: 251 KEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSV 310 E+ R+ ++L L+QA++ D E L+DN I+ + G TTT Sbjct: 218 TERRRTPR-EDLLTHLVQAEV-----------DGERLTDNEIVNVANILLVTGHITTTMT 265 Query: 311 VKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPML 370 + T+ L +P+V K+ R L+ I E LR+ + Sbjct: 266 LGNTVLCLDADPEVAAKV------------------RADRSLVPGAIEEALRVLSPSA-A 306 Query: 371 IPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSV 430 + + + + + K V++ L A + + +++ P+ + P R NP Sbjct: 307 LARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDPTRDPNP---------- 356 Query: 431 SYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVV 483 + FG G C+G LAR E + + L RF + D + P+ P ++ Sbjct: 357 -HFGFGRGIHFCLGAPLARLEGRVALNALFDRFPVLRTDPAKPPTFFPTPDMI 408 >5L94-A nrPDB Length = 410 Score = 197 bits (501), Expect = 9e-51, Method: Composition-based stats. Identities = 81/405 (20%), Positives = 146/405 (36%), Gaps = 67/405 (16%) Query: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALF 135 V H+ KEVL +K S R + I R L F Sbjct: 49 VFHYDGVKEVLEQKNIFSSDRRPPQNQRQTALGTSLINI--DPPKHAEMRALVNKAFT-- 104 Query: 136 KDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPEL 195 + E I + + L + + IDI + + ++ ++ Sbjct: 105 PKAMKAWEPKIARITNELLQEVEHL--EDIDIVEHLSYPLPVMVIADILGVPIEDQRQ-- 160 Query: 196 NVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255 +++++ I+ S + +TLEKL+ ND L E+ R Sbjct: 161 --FKDWSDIIVAGPSNNE------------RETLEKLQQEKMKANDELETYFYRIIEEKR 206 Query: 256 SDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTL 315 + +++ L+QAK ++ + L+D I+ + AG ETTT+++ T+ Sbjct: 207 TRPGDDIISVLLQAK-----------EEGKQLTDEEIVGFSILLLIAGNETTTNLISNTI 255 Query: 316 AFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKA 375 L+ + ++L E + LL + I EVLR R + Sbjct: 256 YCLMEDKASFERLKREKE------------------LLPSGIEEVLRYRSPV-QALHRIV 296 Query: 376 NVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPF 435 D ++ + G V+ + + H + + + P+ F +R N ++ F Sbjct: 297 KEDVTLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDRKPNV-----------HMAF 345 Query: 436 GAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480 G G C+G LAR E +++A L+ R+ P PS E P Sbjct: 346 GRGIHFCLGAPLARIEAKIMLAELIDRY----PQMDWSPSFELKP 386 >3EJB-B nrPDB Length = 404 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 86/461 (18%), Positives = 156/461 (33%), Gaps = 81/461 (17%) Query: 52 NFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRK- 110 +F+ + PIY V ++ +L K F R + + Sbjct: 17 SFYDTLRAVHPIYKGSFLKYPGWYVTGYEETAAIL--KDARFKVRTPLPESSTKYQDLSH 74 Query: 111 ----GIAFADSGAHWQLHRRL-AMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSI 165 + F + HRRL +A+ A + + I + + L D + + Sbjct: 75 VQNQMMLFQNQP----DHRRLRTLASGAFTPRTTESYQPYIIETVHHLLDQVQG-KKKME 129 Query: 166 DISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFP 225 IS F + VI+ I D E ++ + +I +D Sbjct: 130 VISDFAFPLASFVIANII---GVPEEDRE--QLKEWAASLIQT------IDFTRS----- 173 Query: 226 NKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSE 285 K L + ++++ K + +M+ L++ + + + Sbjct: 174 RKALTEGNIMAVQAMAYFKELIQKRKRHPQ----QDMISMLLKGR------------EKD 217 Query: 286 LLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTIS 345 L++ +T + AG ETT +++ ++ LL +P+ KL E D Sbjct: 218 KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPD------------ 265 Query: 346 DRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKE 405 L+ + E LR M A+ D I + +G +V + L A + + Sbjct: 266 ------LIGTAVEECLRYESPTQM-TARVASEDIDICGVTIRQGEQVYLLLGAANRDPSI 318 Query: 406 WHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL 465 + PD F R NP +L FG G C+G LAR E + + LLQR Sbjct: 319 FTNPDVFDITRSPNP-----------HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMP- 366 Query: 466 EVPDDGQLPSLEGIPKVVFLIDSF-KVKIKVRQAWREAQAE 505 L E + +F + ++ + +W Q E Sbjct: 367 ----SLNLADFEWRYRPLFGFRALEELPVTFEASWSHPQFE 403 >5OFQ-A nrPDB Length = 409 Score = 191 bits (484), Expect = 7e-49, Method: Composition-based stats. Identities = 68/416 (16%), Positives = 141/416 (33%), Gaps = 71/416 (17%) Query: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALF 135 V ++ K +L P + + A R+ R L F Sbjct: 54 VFDYETVKYILKN--------PSLFSSKRAMEERQESILMMDPPKHTKLRNLVNKAFT-- 103 Query: 136 KDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPEL 195 Q LE I + L D + + + DI + ++ + Sbjct: 104 PRAIQHLEGHIEEIADYLLDEV--SSKEKFDIVEDFAGPLPIIVIAELLGVPI----QDR 157 Query: 196 NVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255 + + Y++ ++ +S K+ L + + + Sbjct: 158 ALFKKYSDDLVSGAENNSDEAF------------AKMMQKRNEGVIFLQGYFKEIIAERQ 205 Query: 256 SDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTL 315 + +++ L++A++ D E L++ +L + AG ETTT+++ + Sbjct: 206 QNKQEDLISLLLEAEI-----------DGEHLTEEEVLGFCILLLVAGNETTTNLITNGV 254 Query: 316 AFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKA 375 ++ + V+ ++ +I L+ + E LR P I A Sbjct: 255 RYMTEDVDVQNEVRRDI------------------SLVPNLVEETLRYYPPI-QAIGRIA 295 Query: 376 NVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPF 435 D +GE + +G +VI + + + ++ PD F+ R NP ++ F Sbjct: 296 AEDVELGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHRKTNP-----------HVSF 344 Query: 436 GAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKV 491 G G C+G LAR E + LL++ + L ++ VF + +++ Sbjct: 345 GFGIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPIDS--PFVFGVKKYEI 398 >4RM4-A nrPDB Length = 396 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 76/416 (18%), Positives = 146/416 (35%), Gaps = 73/416 (17%) Query: 79 HQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDG 138 + K+V + + FS T I I D H + R + F Sbjct: 53 YDDVKKV-VGDKELFSSCMPQQTSSI----GNSIINMDPPKHTK-IRSVVNKAFT--PRV 104 Query: 139 DQKLEKIICQEISTLCDMLATHNGQS-IDISFPVFVAVTNVISLICFNTSYKNGDPELNV 197 ++ E I + L G+S D+ + ++ + Sbjct: 105 MKQWEPRIQEITDELI---QKFQGRSEFDLVHDFSYPLPVIVISELLGV----PSAHMEQ 157 Query: 198 IQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSD 257 + +++ ++ S + LE+ + I+E R+ Sbjct: 158 FKAWSDLLVSTPKDKS--------EEAEKAFLEERDKCEEELAAFFAGIIEE----KRNK 205 Query: 258 SITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAF 317 +++ L++A ++ E LS ++ + AG ETTT+++ + Sbjct: 206 PEQDIISILVEA-----------EETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYS 254 Query: 318 LLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANV 377 +L P V ++L R+ L+ + E LR R AP+L A Sbjct: 255 ILETPGVYEEL------------------RSHPELMPQAVEEALRFRAPAPVL-RRIAKR 295 Query: 378 DSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGA 437 D+ IG + +G V+ + + + +E ++ +P F R NP ++ FG Sbjct: 296 DTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRRHPNP-----------HIAFGH 344 Query: 438 GPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKI 493 G C+G LAR E + + L+ F P + V++ + SF+VK+ Sbjct: 345 GIHFCLGAPLARLEANIALTSLISAF----PHMECVSITPIENSVIYGLKSFRVKM 396 >5VWS-A nrPDB Length = 393 Score = 185 bits (470), Expect = 4e-47, Method: Composition-based stats. Identities = 74/424 (17%), Positives = 145/424 (34%), Gaps = 69/424 (16%) Query: 41 PFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMA 100 P L G + + + P++ + G V + +++L S R ++ Sbjct: 11 PSLTDGGAALFAWLRTMRNEHPVWRDQFG---IYHVFRYDDVRQILGDYQTFSSDRTRLM 67 Query: 101 TLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATH 160 + GI D H + RRL T A +E I Q L D L Sbjct: 68 P-TAQGFGKGGITMIDPPEH-RHQRRLI--THAFTPQSISAMEPRIRQIADHLLDEL--- 120 Query: 161 NGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPW 220 G D+ + ++ GD ++ + +++ ++ ++ Sbjct: 121 PGPEFDLVEHFAYPLPVIVIAELLG--VPPGDR--HLFRTWSDRLMSLQVENYADP---- 172 Query: 221 LKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGP 280 +L V +N L + R+ ++L L+QA++ Sbjct: 173 ----------ELARTVAAAMTEMNDYLREHCRSRRTHPRDDLLTRLVQAEVE-------- 214 Query: 281 DQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSR 340 + L ++ T + AG TTT ++ T+ L +P+ +K + + Sbjct: 215 ---GKRLDLEEVVNTASLLLLAGHLTTTVLIGNTMLCLWDHPEAEKAVRADP-------- 263 Query: 341 TPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALH 400 L+ A + E LRLR + D +I + V+ + + + Sbjct: 264 ----------SLIPAALEESLRLRSPF-LQAGRVTTRDVTIAGETIPANRFVMAWILSAN 312 Query: 401 HNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLL 460 H+++ + P++F R + ++ FG G C+G L R E + + LL Sbjct: 313 HDDRRFPDPERFDLHR-----------QTTGHIAFGHGVHFCLGAQLGRLEGRIALERLL 361 Query: 461 QRFD 464 RF Sbjct: 362 GRFT 365 >6M7X-A nrPDB Length = 484 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 85/456 (18%), Positives = 169/456 (37%), Gaps = 56/456 (12%) Query: 16 FWPKRRCPGAKYPKSLLSLPLVGS----LPFLPRHGHMHNNFFKLQKKY---GPIYSVRM 68 P+ P P+ G+ L + R + ++ + + GPI+ + Sbjct: 7 SVPRTVLPFEAMPRRP------GNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDL 60 Query: 69 GTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRK---GIAFADSGAHWQLHR 125 G V V + E L + R + +R G+ + G W+ +R Sbjct: 61 GGAGMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLN-GPEWRFNR 118 Query: 126 RLAMATFALFKDGDQKLEKIICQEISTLCDMLAT-----HNGQ-SIDISFPVFVAVTNVI 179 L + L + Q+ ++ L G ++D+ +F Sbjct: 119 -LRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEAS 177 Query: 180 SLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIR 239 +L F G++ + + ++ + L++ T++ + + Sbjct: 178 NLALFGERL---------------GLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLS 222 Query: 240 NDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSEL---------LSDN 290 K+ + + E + D I D +Q K+ + + P Q + + LS + Sbjct: 223 RWTSPKVWKEHFEAW--DCIFQYGDNCIQ-KIYQELAFSRPQQYTSIVAELLLNAELSPD 279 Query: 291 HILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRL 350 I ++ V+TT + TL L NP V++ L +E L Sbjct: 280 AIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTEL 339 Query: 351 LLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPD 410 LL A ++E LRL PV + + A+ D + + + GT V + L++L N + +P+ Sbjct: 340 PLLRAALKETLRLYPVG-LFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPE 398 Query: 411 QFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEI 446 ++ P+R+L+ G+ + ++PFG G R C+G Sbjct: 399 RYNPQRWLDIRGSG---RNFYHVPFGFGMRQCLGRR 431 >4ZGX-A nrPDB Length = 489 Score = 183 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 81/418 (19%), Positives = 151/418 (36%), Gaps = 45/418 (10%) Query: 46 HGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIA 105 H MH F +L GPI+ +G V V + E L + R + Sbjct: 42 HLEMHQTFQEL----GPIFRYNLGGPRMVCVMLPEDV-EKLQQVDSLHPCRMILEPWVAY 96 Query: 106 SNNRK---GIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLAT--- 159 +R G+ + G W+ +R L + L Q+ ++ L Sbjct: 97 RQHRGHKCGVFLLN-GPEWRFNR-LRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVL 154 Query: 160 --HNGQ-SIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVD 216 G ++D+ +F +L F G++ + + ++ Sbjct: 155 QNARGSLTLDVQPSIFHYTIEASNLALFGERL---------------GLVGHSPSSASLN 199 Query: 217 LVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNG 276 + L++ T++ + + + K+ + + E + D I D +Q Sbjct: 200 FLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAW--DCIFQYGDNCIQKIYQELAF 257 Query: 277 NAGPDQDS--------ELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKL 328 N LS I ++ V+TT + TL L NP V++ L Sbjct: 258 NRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQIL 317 Query: 329 YEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDK 388 +E L LL A ++E LRL PV + + + D + + + Sbjct: 318 RQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVG-LFLERVVSSDLVLQNYHIPA 376 Query: 389 GTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEI 446 GT V + L++L N + +P+++ P+R+L+ G+ + ++PFG G R C+G Sbjct: 377 GTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSG---RNFHHVPFGFGMRQCLGRR 431 >4Z5P-A nrPDB Length = 400 Score = 182 bits (461), Expect = 4e-46, Method: Composition-based stats. Identities = 78/431 (18%), Positives = 142/431 (32%), Gaps = 73/431 (16%) Query: 46 HGHMHNNFFKLQKKYGPIYSVRM-GTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDI 104 +H F +L++ P+ VR+ +V + + + + Sbjct: 19 GLEIHPKFAELRET-DPLARVRLPYGGEGWMVTRYDDVRAANSDPRFSRAQIGEDTPRTT 77 Query: 105 ASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQS 164 R + RRL F + G ++ + + + L D + G Sbjct: 78 PLARRSDTILSLDPPEHTRLRRLLSKAFTARRMG--AMQSWLEELFAGLLDGVERT-GHP 134 Query: 165 IDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIF 224 DI + A I++IC D Q+++E I+ + Sbjct: 135 ADIVRDL--AQPFTIAVICRLLGVPYEDRGR--FQHWSEVIMSTTAYS------------ 178 Query: 225 PNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDS 284 K + + L + R+ ++L L+ A+ D Sbjct: 179 --------KEEAVSADASIRAYLADLVSARRAAPHDDLLGVLVSAR-----------DDD 219 Query: 285 ELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTI 344 + L+++ ++T + AG ET+ + + LL + L E+ + Sbjct: 220 DRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSLLREQPE----------- 268 Query: 345 SDRNRLLLLEATIREVLRLRPVAP-MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNE 403 LL + E+LR P+ + A D + V G V+ + + Sbjct: 269 -------LLPRAVEELLRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDP 321 Query: 404 KEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 + + PD+ R NP +L FG G C+G LAR EL + + LL+RF Sbjct: 322 RAFDDPDRLDITREKNP-----------HLAFGHGAHYCLGAQLARMELRVAIGGLLERF 370 Query: 464 ---DLEVPDDG 471 L VP D Sbjct: 371 PGLRLAVPADQ 381 >2Y5N-A nrPDB Length = 417 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 69/393 (17%), Positives = 134/393 (34%), Gaps = 76/393 (19%) Query: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNR---KGIAFADSGAHWQLHRRLAMATF 132 V ++ + VL G R T D KG + RRL + F Sbjct: 66 VTRYEDVRAVL---GDGRFVRGPSMTRDEPRTRPEMVKGGLLSMDPPEHSRLRRLVVKAF 122 Query: 133 ALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFV-AVTNVISLICFNTSYKNG 191 + L + L D +A GQ D+ VI + S + Sbjct: 123 T--ARRAESLRPRAREIAHELVDQMAAT-GQPADLVAMFARQLPVRVICELLGVPSADHD 179 Query: 192 DPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYK 251 ++ + T E+++ + + +++ + Sbjct: 180 R-----FTRWSGAFLSTAEV----------------TAEEMQEAAEQAYAYMGDLIDRRR 218 Query: 252 EKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVV 311 + +++ L+QA+ D+ LS+ +L + AG E+TT+ + Sbjct: 219 ----KEPTDDLVSALVQARDQQDS-----------LSEQELLDLAIGLLVAGYESTTTQI 263 Query: 312 KWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAP-ML 370 + L+ P+++++L +R L+ + + E+ R P+ Sbjct: 264 ADFVYLLMTRPELRRQL------------------LDRPELIPSAVEELTRWVPLGVGTA 305 Query: 371 IPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSV 430 P A D ++ + G V+ + A + ++ ++ D+ +R N Sbjct: 306 FPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDRTPN----------- 354 Query: 431 SYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 +L FG G C+G LAR EL + + LLQR Sbjct: 355 QHLGFGHGVHHCLGAPLARVELQVALEVLLQRL 387 >2VZM-A nrPDB Length = 436 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 76/446 (17%), Positives = 146/446 (32%), Gaps = 75/446 (16%) Query: 19 KRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRM-GTKTTVIVG 77 +R G +L L +G + + +L+ + GP + VR +V Sbjct: 22 RRTQQGTTASPPVLDLGALG----QDFAADPYPTYARLRAE-GPAHRVRTPEGNEVWLVV 76 Query: 78 HHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKD 137 + A+ VL R L A R+L F + + Sbjct: 77 GYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRV 136 Query: 138 GDQKLEKIICQEISTLCDM-LATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELN 196 L + + + L D LA +G++ + + VIS + +P+ Sbjct: 137 EL--LRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELL-----GVPEPDRA 189 Query: 197 VIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRS 256 + + + + FP+ + ++ + + L+++++ R Sbjct: 190 AFRVWTDAFV-----------------FPDDPAQA-QTAMAEMSGYLSRLID----SKRG 227 Query: 257 DSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLA 316 ++L L++ D+D L+ +L + AG ETT +++ + Sbjct: 228 QDGEDLLSALVR----------TSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMY 277 Query: 317 FLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKAN 376 LL +P L R + LL+ + E+LR Sbjct: 278 ALLSHPDQLAAL------------------RADMTLLDGAVEEMLRYEGPVESATYRFPV 319 Query: 377 VDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFG 436 + + G V++ L H + + P +F R + +L FG Sbjct: 320 EPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRR-----------DTAGHLAFG 368 Query: 437 AGPRSCIGEILARQELFLIMAWLLQR 462 G CIG LAR E + + LL+R Sbjct: 369 HGIHFCIGAPLARLEARIAVRALLER 394 >4UBS-A nrPDB Length = 393 Score = 178 bits (452), Expect = 4e-45, Method: Composition-based stats. Identities = 69/432 (15%), Positives = 145/432 (33%), Gaps = 81/432 (18%) Query: 64 YSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMAT-----LDIASNNRKGIAFADSG 118 S+ G ++ +V H A+ +L + + R + D Sbjct: 31 VSLYDG-RSVWVVTGHAAARALLSDQRLSSDRTLPRFPATTERFEAVRTRRVALLGVDDP 89 Query: 119 AHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNV 178 H + RR+ + +F L + L I + + L D + + +S + V Sbjct: 90 EH-RTQRRMLVPSFTLKRAA--ALRPRIQETVDGLLDAMEAQGPPAELVSAFALPLPSMV 146 Query: 179 ISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKI 238 I + D + Q+ ++ + +++ Sbjct: 147 ICALL---GVPYADHDFFESQSR--------------------RLLRGPGIAEVQDARAQ 183 Query: 239 RNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGD 298 +D L +++ + R + +LD L+Q ++N + +++ Sbjct: 184 LDDYLYALID----RKRKEPGDGLLDDLIQEQLNRGTVDRA-----------ELVSLATL 228 Query: 299 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIR 358 + AG ETT +++ LL +P+ +L E L+ A + Sbjct: 229 LLIAGHETTANMISLGTFTLLRHPEQLAELRAEP------------------GLMPAAVE 270 Query: 359 EVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418 E+LR +A L+ A D + + V+ ++ + + +PD R Sbjct: 271 ELLRFLSIADGLL-RVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHR-- 327 Query: 419 NPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR---FDLEVP-DDGQLP 474 + ++ FG G C+G+ LAR E+ + + L +R L P D+ Sbjct: 328 ---------SARHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLAAPADEIPFK 378 Query: 475 SLEGIPKVVFLI 486 + I ++ L Sbjct: 379 PGDTIQGMLELP 390 >4YZR-A nrPDB Length = 405 Score = 178 bits (452), Expect = 4e-45, Method: Composition-based stats. Identities = 67/378 (17%), Positives = 132/378 (34%), Gaps = 78/378 (20%) Query: 113 AFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVF 172 A R L F + L I Q L D + N DI Sbjct: 91 MLAKDTPDHTRLRSLVHQAFT--PRTIENLRGSIEQIAEQLLDEMEKENKA--DIMKSFA 146 Query: 173 VAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKL 232 + ++ ++ + +++VD + N+ L + Sbjct: 147 SPLPFIVISELMGIPKEDRSQF-------------QIWTNAMVDTSEGNRELTNQALREF 193 Query: 233 KSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292 K D + K++ + + K + D I+ ++ +++ LS+ + Sbjct: 194 K-------DYIAKLIHDRRIKPKDDLISKLVHA---------------EENGSKLSEKEL 231 Query: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352 + + + AG+ETT +++ LL + + +KL ++ + + Sbjct: 232 YSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPE------------------M 273 Query: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412 + + E+LR M+ A D + ++ +G + I + + + + + P+ Sbjct: 274 IATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEIL 333 Query: 413 MPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF-DLEV---P 468 R N ++ FG G C+G LAR E + LL+RF D+E+ P Sbjct: 334 NINRSPN-----------RHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAP 382 Query: 469 DDGQ------LPSLEGIP 480 DD Q L LE +P Sbjct: 383 DDIQWRKNVFLRGLESLP 400 >5XW2-A nrPDB Length = 419 Score = 178 bits (451), Expect = 6e-45, Method: Composition-based stats. Identities = 71/401 (17%), Positives = 137/401 (34%), Gaps = 57/401 (14%) Query: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALF 135 V + A EVL G S ++ + +G + R+L F Sbjct: 57 VYGYAEAIEVLGDPGTFSSHMSRLLPMGADEAFTEGDLLQTDPPDHRELRKLVSHAFT-- 114 Query: 136 KDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPEL 195 +LE I L D +A + +F + A+ + + + Sbjct: 115 PKVVAELEPRITALTQELLDAVADRD------TFDLMTALAYPLPVTVVAELLSIPSADR 168 Query: 196 NVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255 ++ + + I+ +L S+ D P ++ + +L + E + + R Sbjct: 169 HLFEGWMTEIVHSLGDVSMEDA-------PEDQERIFEAGMAPMRKMLEYLRE-HAAECR 220 Query: 256 SDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTL 315 +++ L++A++ D L+DNHI+ + AG TTT ++ T+ Sbjct: 221 RRPRGDLMGKLIEAEV-----------DGRRLTDNHIVNFAKMLLIAGYLTTTMLIGNTV 269 Query: 316 AFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKA 375 L P+ ++ R L+ + E +R Sbjct: 270 LCLDSYPEQAARV------------------RADRSLIPGLLEESMRFLSPVAATY-RAT 310 Query: 376 NVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPF 435 D + + V++ A + + +++ +P+ F R NP +L F Sbjct: 311 TRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPELFDMTRGPNP-----------HLGF 359 Query: 436 GAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSL 476 G G C+G LAR E + + LL RF D + P+ Sbjct: 360 GRGIHFCLGGPLARMEGRVALDHLLDRFPELYTDPERPPTF 400 >1ODO-A nrPDB Length = 408 Score = 178 bits (450), Expect = 7e-45, Method: Composition-based stats. Identities = 75/430 (17%), Positives = 137/430 (31%), Gaps = 79/430 (18%) Query: 76 VGHHQLAKEVLIKKGKDFSGRPQMATL-DIASNNRKGI------AFADSGAHWQLHRRLA 128 V L K++L R ++ + F G + + RRL Sbjct: 43 VSDPVLLKQLLTSSDVSKDARAHWPAFGEVVGTWPLALWVAVENMFTAYGPNHRKLRRLV 102 Query: 129 MATFALFKDGDQKLEKIICQEISTLCDMLATHN-GQSIDISFPVFVAVTNVISLICFNTS 187 F + + ++ L D LA G+ +D+ + + + Sbjct: 103 APAF--SARRVDAMRPAVEAMVTGLVDRLAELPAGEPVDLRQELAYPLPIAVIGHLMGVP 160 Query: 188 YKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKIL 247 D ++ + +D ++ + L ++L Sbjct: 161 QDRRDGFRALVDGVFDTTLD-------------------------QAEAQANTARLYEVL 195 Query: 248 ENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETT 307 + R+ +M L+ A+ + D + LS + T+ + AG ETT Sbjct: 196 DQLIAAKRATPGDDMTSLLIAAR--------DDEGDGDRLSPEELRDTLLLMISAGYETT 247 Query: 308 TSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVA 367 +V+ + LL P + + T +D + E LR P Sbjct: 248 VNVIDQAVHTLLTRPDQLALVRK---------GEVTWAD---------VVEETLRHEPAV 289 Query: 368 PMLIPHKANVDSSI-GEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLI 426 L A D ++ + +G ++ + A + + D F R + Sbjct: 290 KHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADTFDATRTVKE------ 343 Query: 427 SPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF-DLEVPDDGQLPSLEGIPKVVFL 485 +L FG G C+G LAR E+ L + L RF DL + D E +P V L Sbjct: 344 -----HLAFGHGVHFCLGAPLARMEVTLALESLFGRFPDLRLADPA-----EELPPVPSL 393 Query: 486 IDSFKVKIKV 495 I + ++ V Sbjct: 394 ISNGHQRLPV 403 >5CJE-A nrPDB Length = 393 Score = 178 bits (450), Expect = 7e-45, Method: Composition-based stats. Identities = 79/452 (17%), Positives = 154/452 (34%), Gaps = 83/452 (18%) Query: 37 VGSLPFLPRHG-----HMHNNFFKLQKKYGPIYSVRMGTKTTV---IVGHHQLAKEVLIK 88 +G++ L +G + + +L+++ GP++ VR +V H+ A+ L Sbjct: 1 MGNVIDLGEYGARFTEDPYPVYAELRER-GPVHWVRTPPPEAFEGWLVVGHEEARAALAD 59 Query: 89 KGKDFSGRPQ-MATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIIC 147 G + + +LD+ + R L F + + + L I Sbjct: 60 PRLSKDGTKKGLTSLDVELMGPYLLVV--DPPEHTRLRSLVARAFTMRR--VEALRPRIQ 115 Query: 148 QEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIID 207 + L D + G++ + + VI + D + + + I+ Sbjct: 116 EITDGLLDEMLP-RGRADLVDSFAYPLPITVICELL-----GVPDIDRVTFRALSNEIVA 169 Query: 208 NLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLM 267 D+ + + + L++++++ + +D ++L L+ Sbjct: 170 PTGGDAEL------------------AAYERLAAYLDELIDDKRSTAPAD---DLLGDLI 208 Query: 268 QAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKK 327 + + +D + LS + + AG ETT +++ + LL +P Sbjct: 209 RTRA----------EDDDRLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAA 258 Query: 328 LYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVD 387 L R + LL+ + EVLR A IG A+ Sbjct: 259 L------------------RADMTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIA 300 Query: 388 KGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEIL 447 +G V+I L A + P F R +L FG G C+G L Sbjct: 301 EGDPVMIGLDAAGRDPARHPDPHVFDIHRAPQ-----------GHLAFGHGIHYCLGAPL 349 Query: 448 ARQELFLIMAWLLQR---FDLEVPDDGQLPSL 476 AR E + + LL+R L+ P + P + Sbjct: 350 ARLEARVALRSLLERCPDLALDGPPGARPPGM 381 >4MM0-A nrPDB Length = 399 Score = 177 bits (449), Expect = 8e-45, Method: Composition-based stats. Identities = 69/394 (17%), Positives = 132/394 (33%), Gaps = 81/394 (20%) Query: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALF 135 V ++ + VL FS R + + RRL F Sbjct: 50 VTRYEDVRFVLSDPR--FSVRQDLPGAPRLTEMTFESVMTTDPPVHTRLRRLLSRDFT-- 105 Query: 136 KDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPEL 195 +++ + + L D + G D Sbjct: 106 ARRIERMRPRLEEIAEGLLDEMEK-KGAPAD----------------------------- 135 Query: 196 NVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255 I+++L+ + ++ L P + + + L +E++ Sbjct: 136 ---------IVESLAVPFPITVICELLGVPMVDVARFRGWADTMVSLTGYSMEDWTAAR- 185 Query: 256 SDSITNMLDTLMQAKMNSDNGN------AGPDQDSELLSDNHILTTIGDIFGAGVETTTS 309 D++ + LD L+ AK + + A +D+E L+D+ + + + AG E ++ Sbjct: 186 -DALESYLDGLVAAKRENPGSDLLSALVATAAEDNE-LTDHDVRSLSLILLLAGYEPASN 243 Query: 310 VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPM 369 + ++ LL P +L R LL + + E++R P Sbjct: 244 QLGSSVLTLLRFPDRLAEL------------------RRDPGLLPSAVEELMRYAPAGDG 285 Query: 370 LIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPS 429 + D +IG+ + + V+ + A + + P RF +P G +L P Sbjct: 286 ALFRVTLEDVTIGDTHIPANSAVLASTQAAN-----------WDPRRFDDPTGLRLDRPD 334 Query: 430 VSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 + G G C+G LAR EL + + LL+RF Sbjct: 335 NQHTALGHGIHFCLGAALARVELQVAIGALLRRF 368 >5XNT-A nrPDB Length = 411 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 68/405 (16%), Positives = 151/405 (37%), Gaps = 73/405 (18%) Query: 79 HQLAKEVLIKKGKDFSGRPQMATLDIASNNRKG-----IAFADSGAHWQLHRRLAMATFA 133 ++ K VL K FS + T+ + +++ +G I ++ RR ++ A Sbjct: 49 YEDVKRVLSDY-KHFSSVRKRTTISVGTDSEEGSVPDKIKITEADPPEHRKRR-SLLAAA 106 Query: 134 LFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDP 193 Q E I + L + + + ++ + + +I + Sbjct: 107 FTPRSLQNWEPRIQEIADELIEEMDEET------EIDIVQSLASPLPIIVMSDLMGVPSK 160 Query: 194 ELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK 253 + + + + + + F + E++ ++ + L + Sbjct: 161 DRLLFKKWVDILF---------------LPFDKEKQEEVNELKQVAAKEYYQYLYPIVVQ 205 Query: 254 FRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313 R + +++ L++A++ D E+ +D+ ++ T I GAGVETT+ ++ Sbjct: 206 KRLNPADDIISDLLKAEV-----------DGEMFTDDEVVRTTMLILGAGVETTSHLLAN 254 Query: 314 TLAFLL-HNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIP 372 + LL + +V ++L+E +D L+ + E+LR R + + Sbjct: 255 SFYSLLYDDKEVYQELHENLD------------------LVPQAVEEMLRYR-FNLIKLD 295 Query: 373 HKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSY 432 D+ + + +G V++ + A + +E+ + R N + Sbjct: 296 RTVKEDNDLLGVELKEGENVVVWMSAANLDEEMFEDAFTLNIHRPNNKK----------H 345 Query: 433 LPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLE 477 L FG GP C+G LAR E + + L++F +PS + Sbjct: 346 LTFGNGPHFCLGAPLARLEAKIALTTFLKKFK----HIEAVPSFQ 386 >6GMF-A nrPDB Length = 397 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 84/401 (20%), Positives = 143/401 (35%), Gaps = 71/401 (17%) Query: 67 RMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATL----DIASNNRKGIAFADSGAHWQ 122 R+ + + VG +Q VL K FS R A+L ++ I D H + Sbjct: 31 RLQPQGFMAVGRYQDVARVLHD-AKGFSNRGWAASLPRGVKWDTSMPPSIVQVDPPRHGK 89 Query: 123 LHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLI 182 L + T A +LE I L D L + +F V VT + +I Sbjct: 90 LR---TLVTKAFTPRTVAQLEPRIRDIAHELVDGLRGKS------TFEATVEVTVPMPMI 140 Query: 183 CFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDL 242 + +++ D+V L + +L+ + Sbjct: 141 VIAEMLGVAPERRADFKRWSD------------DMVGSLALVRVGNAAQLERSTQEFYAY 188 Query: 243 LNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGA 302 +++L E+ R + +++ L+ A++ D E L+ +L+ + A Sbjct: 189 FSEVL----EERRREPREDLISQLLAAEV-----------DGEKLTAGEVLSFANTLLIA 233 Query: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLR 362 G ETTTS++ L L +P+ L L+ A + EVLR Sbjct: 234 GNETTTSLIGNALVALTDHPEQLAAAQ------------------ADLSLVPAVVEEVLR 275 Query: 363 LRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAG 422 A I + D IG+ + + V+ L + + +E + PD+F R Sbjct: 276 YESPA-QCIFRQTMTDVEIGDERIPARSVVLPLLASANRDESRFPDPDRFDIHR------ 328 Query: 423 TQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 + +L FG CIG LAR E +++ LL R Sbjct: 329 -----DTKGHLAFGLDIHFCIGAPLARLEAKVMLEVLLARL 364 >3WVS-A nrPDB Length = 401 Score = 176 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 65/366 (17%), Positives = 123/366 (33%), Gaps = 70/366 (19%) Query: 100 ATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLAT 159 N + F RRL F + + ++L + L D + Sbjct: 77 PPRARKFNAQAKSMFNMDAPDHTRLRRLISKAFTIRR--VEELRPKVHDLAHRLIDDMLA 134 Query: 160 HNGQSIDI-SFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLV 218 G+ D+ + T VI + D E + + I+ + + Sbjct: 135 -KGEPADLVADYALPIPTTVICELL---GVPFEDRE--KFGRWTDAILSTSTLNP----- 183 Query: 219 PWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNA 278 E+ + + I+ + + +++ +++A+ D Sbjct: 184 -----------EEGRVKRMELVGYIGGIIAARRAQ----PADDLISGMIEARDVQDK--- 225 Query: 279 GPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGF 338 L++ +L + AG ETT S + + LL PQ K+L ++ + Sbjct: 226 --------LTEQELLDHCIGLLIAGHETTASQIPSFVYALLDQPQHWKRLLDDPE----- 272 Query: 339 SRTPTISDRNRLLLLEATIREVLRLRPVAP-MLIPHKANVDSSIGEFAVDKGTEVIINLW 397 L+ + + E+ R P+ P A D +G V G V++ L Sbjct: 273 -------------LIPSAVEELFRFVPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVALG 319 Query: 398 ALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMA 457 A + + + P++ +R PS ++ FG G C+G LAR EL + Sbjct: 320 AANRDGLRFEDPEEIKLDR-----------PSNHHIGFGHGIHHCLGAPLARLELQEALR 368 Query: 458 WLLQRF 463 LL+R Sbjct: 369 ALLERL 374 >4YT3-A nrPDB Length = 410 Score = 174 bits (442), Expect = 6e-44, Method: Composition-based stats. Identities = 73/405 (18%), Positives = 153/405 (37%), Gaps = 73/405 (18%) Query: 79 HQLAKEVLIKKGKDFSGRPQMATLDIASNNRKG-----IAFADSGAHWQLHRRLAMATFA 133 ++ K VL K FS + T+ + +++ +G I +S RR ++ A Sbjct: 49 YEDVKRVLSDY-KHFSSVRKRTTISVGTDSEEGSVPEKIQITESDPPDHRKRR-SLLAAA 106 Query: 134 LFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDP 193 Q E I + L + G IDI ++ + + +I Sbjct: 107 FTPRSLQNWEPRIQEIADELIGQM--DGGTEIDI----VASLASPLPIIVMADLMGVPSK 160 Query: 194 ELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK 253 + + + + + + F + E++ ++ + L + Sbjct: 161 DRLLFKKWVDTLF---------------LPFDREKQEEVDKLKQVAAKEYYQYLYPIVVQ 205 Query: 254 FRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313 R + +++ L+++++ D E+ +D+ ++ T I GAGVETT+ ++ Sbjct: 206 KRLNPADDIISDLLKSEV-----------DGEMFTDDEVVRTTMLILGAGVETTSHLLAN 254 Query: 314 TLAFLL-HNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIP 372 + LL + +V ++L+E +D L+ + E+LR R + + Sbjct: 255 SFYSLLYDDKEVYQELHENLD------------------LVPQAVEEMLRFR-FNLIKLD 295 Query: 373 HKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSY 432 D+ + + +G V++ + A + +E+ + P R N + Sbjct: 296 RTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHRPNNKK----------H 345 Query: 433 LPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLE 477 L FG GP C+G LAR E + + L++F +PS + Sbjct: 346 LTFGNGPHFCLGAPLARLEAKIALTAFLKKFK----HIEAVPSFQ 386 >6A7J-A nrPDB Length = 411 Score = 173 bits (437), Expect = 3e-43, Method: Composition-based stats. Identities = 85/426 (19%), Positives = 145/426 (34%), Gaps = 88/426 (20%) Query: 61 GPIYSVRM-GTKTTVIVGHHQLAKEVLIKKGKDFS-------GRPQMA---TLDIASNNR 109 GP+ V + G V HH+ A+ +L R ++ L N Sbjct: 26 GPLAEVELPGGVHVYAVTHHKEARALLTDSRVVKDINVWNAWQRGEIPADWPLIGLVNPG 85 Query: 110 KGIAFADSGAHWQLHRRL-AMATFALFKDGDQKLEKIICQEISTLCDMLATHN-GQSIDI 167 + + D HRRL + AL +KL I + + LA G+ +D+ Sbjct: 86 RSMLTVDGP----DHRRLRTLVAQALTVKRVEKLRAGIEALTNASLERLAALPAGEPVDL 141 Query: 168 SFPV-FVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPN 226 + NVIS + + ++ E + V Sbjct: 142 KAEFAYPLPMNVISELM-----GVDAADHPRLKELFEKFFSTQTPPEEVP---------- 186 Query: 227 KTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSEL 286 L + E+ +++ ++ L+ A +D + Sbjct: 187 -----------QMMADLGTLFTKIVEEKKANPGDDLTSALIAAS-----------EDGDH 224 Query: 287 LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD 346 L+D IL T+ I AG ETT S++ + L +P+ +KK+ Sbjct: 225 LTDEEILNTLQLIIAAGHETTISLIVNVVEALAIHPEQRKKVLSGEIPW----------- 273 Query: 347 RNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW 406 E I E LR ++ A D +G+ + KG ++++ AL +E+++ Sbjct: 274 -------EGVIEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQY 326 Query: 407 -HQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF-- 463 F R N ++ FG GP C G L+R E + + L +RF Sbjct: 327 GPTAGDFDATRTPN-----------RHIAFGHGPHVCPGAALSRLEAGIALPALYERFPE 375 Query: 464 -DLEVP 468 DL VP Sbjct: 376 LDLAVP 381 >2ZBZ-A nrPDB Length = 412 Score = 171 bits (433), Expect = 6e-43, Method: Composition-based stats. Identities = 67/437 (15%), Positives = 151/437 (34%), Gaps = 83/437 (18%) Query: 48 HMHNNFFKLQKKYGPIYSVRMG-TKTTVIVGHHQLAKEVL-------IKKGKDFSGRPQM 99 + + + +L+ GP++ V + + +V H+ A+++L + +F Sbjct: 25 QLPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSP- 83 Query: 100 ATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLAT 159 + + + D H RR+ ++ F + + + + + + + D + Sbjct: 84 -AFEAVRESPQAFIGLDPPEH-GTRRRMTISEFTVKR--IKGMRPEVEEVVHGFLDEMLA 139 Query: 160 HNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVP 219 + +S + VI + D E Q+ ++ ++ + S + Sbjct: 140 AGPTADLVSQFALPVPSMVICRLL---GVPYADHEF--FQDASKRLVQSTDAQSAL---- 190 Query: 220 WLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAG 279 + L+ ++ F+++ ++ L+ ++ + Sbjct: 191 --------------TARNDLAGYLDGLITQ----FQTEPGAGLVGALVADQLANGE---- 228 Query: 280 PDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFS 339 + +++T + AG ETT S+ ++ LL +P+ L Sbjct: 229 -------IDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAAL----------- 270 Query: 340 RTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWAL 399 R L+ + E+LR +A + A D + + G VI+ Sbjct: 271 -------RADRSLVPGAVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIA 323 Query: 400 HHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWL 459 + + + PD R + +L FG G C+G+ LAR EL +I+ L Sbjct: 324 NRDGTVYEDPDALDIHR-----------SARHHLAFGFGVHQCLGQNLARLELEVILNAL 372 Query: 460 LQR---FDLEVPDDGQL 473 + R L VP + + Sbjct: 373 MDRVPTLRLAVPVEQLV 389 >4JBT-A nrPDB Length = 410 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 78/443 (17%), Positives = 150/443 (33%), Gaps = 88/443 (19%) Query: 61 GPIYSVRMGTKTTVIVGHHQLAKEVLIKK-----------GKDFSGRPQMATLDIASNNR 109 GP+ + + + V H LA+++L + + Q + + +R Sbjct: 30 GPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDINAWSLWQSGTVTRQWPLIGMIDVDR 89 Query: 110 KGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLA--THNGQSIDI 167 F G + R T AL + L+ I + ++ L D L +G +D+ Sbjct: 90 S--MFTVDGPEHRRLR--IKTTQALTRRRLDALKPTIERYVAELLDDLERAGADGAVVDL 145 Query: 168 SFPV-FVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPN 226 + VIS + + D E + + + L+ Sbjct: 146 KSVFAYPLPMRVISALM---GVPSEDQE--QLLTWYKAFFSILT---------------- 184 Query: 227 KTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSEL 286 E+L+ D ++ + ++ ++ L+ A Sbjct: 185 PQDERLR-----VIDEMHGYFTEMVRRKTAEPGDDLTSALIYATDGE-----------TP 228 Query: 287 LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD 346 L++ ++ + + AG ETT S++ + LL +P+ + + D +G+ Sbjct: 229 LTEEEVIGNLQALVAAGHETTVSLILTAVRALLSHPEQLRLVR---DGEIGW-------- 277 Query: 347 RNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW 406 E I E LR L+ A D +G+ + +G V+++ A+ + Sbjct: 278 -------ETAIEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVH 330 Query: 407 H-QPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDL 465 D F R + + ++ FG GP C G LAR E + + L RF Sbjct: 331 GADADDFDITR----------ATAARHISFGHGPHICPGAALARLEAAIALPALFTRF-- 378 Query: 466 EVPDDGQLPSLEGIPKVVFLIDS 488 P L+ IP + L + Sbjct: 379 --PHLHPALPLDQIPNLPVLTQN 399 >3A50-A nrPDB Length = 411 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 76/461 (16%), Positives = 149/461 (32%), Gaps = 84/461 (18%) Query: 48 HMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGR---PQMATLDI 104 + H + L+ + P+ + + ++ + +E + R P+ D+ Sbjct: 21 NPHPAYAALRAE-DPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHRLPEDQRADM 79 Query: 105 ASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQS 164 + + D H R+L +F + + +LE I + L L T Sbjct: 80 PATPTPMMILMDPPDH-TRLRKLVGRSFTVRRM--NELEPRITEIADGLLAGLPTDG--P 134 Query: 165 IDI-SFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKI 223 +D+ F VI + L + D W + Sbjct: 135 VDLMREYAFQIPVQVICELL------------------------GLPAEDRDDFSAWSSV 170 Query: 224 FPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQD 283 + + K+ + L+ L + E+ R++ +L +L+ D D Sbjct: 171 LVDDSPADDKNAAMGK---LHGYLSDLLERKRTEPDDALLSSLLAV----------SDMD 217 Query: 284 SELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPT 343 + LS ++ + AG ETT +++ + LL +P +K L E+ Sbjct: 218 GDRLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPDQRKLLAEDP----------- 266 Query: 344 ISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNE 403 L+ + + E LR D + + G V++ L A + + Sbjct: 267 -------SLISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDA 319 Query: 404 KEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 +PD+ R + +G FG G C+G LAR E + + L Sbjct: 320 DWMPEPDRLDITR--DASGGVF---------FGHGIHFCLGAQLARLEGRVAIGRLFA-- 366 Query: 464 DLEVPDDGQLPSLEGI----PKVVFLIDSFKVKIKVRQAWR 500 + P+ L+ + +V + V + R A Sbjct: 367 --DRPELALAVGLDELVYRRSTLVRGLSRMPVTMGPRSALE 405 >3ABB-A nrPDB Length = 408 Score = 169 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 69/420 (16%), Positives = 139/420 (33%), Gaps = 78/420 (18%) Query: 62 PIYSVRMG-TKTTVIVGHHQLAKEVLIKKGKDFS-GRPQMATLDIASNNRKGIAFADSG- 118 P+ V + + ++ H + +L+ G P + + +R G+AF G Sbjct: 38 PLTQVTLFDGRPAWLITGHAEGRALLVDPRLSSDWGHPDFPVVVRRTEDRGGLAFPLIGV 97 Query: 119 --AHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVT 176 RR+ + +F + + + + + L D + G D+ + V Sbjct: 98 DDPVHARQRRMLIPSFGVKRM--NAIRPRLQSLVDRLLDDMLA-KGPGADLVSAFALPVP 154 Query: 177 NVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHV 236 +V IC GD + + + + + L Sbjct: 155 SV--AICELLGVPYGDHDF--FEECSRNFVGAATSAEADAAFGELY-------------- 196 Query: 237 KIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTI 296 L + +++ +LD L+ ++ + L + ++ Sbjct: 197 --------TYLHGLVGRKQAEPEDGLLDELIARQLEEGD-----------LDHDEVVMIA 237 Query: 297 GDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEAT 356 + AG ETT + + L+ +P+ L + G Sbjct: 238 LVLLVAGHETTVNAIALGALTLIQHPEQIDVLLRDPGAVSG------------------V 279 Query: 357 IREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPER 416 + E+LR V+ ++ A D +G + G V++++ ++ + K + PD F R Sbjct: 280 VEELLRFTSVSDHIV-RMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFDARR 338 Query: 417 FLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR---FDLEVPDDGQL 473 + ++ FG G C+G+ LAR EL + + L R L VP D Sbjct: 339 -----------NARHHVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLAVPLDEVP 387 >2Z36-A nrPDB Length = 413 Score = 168 bits (426), Expect = 5e-42, Method: Composition-based stats. Identities = 62/408 (15%), Positives = 129/408 (31%), Gaps = 78/408 (19%) Query: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIAS-------NNRKGIAFADSGAHWQLHRRLA 128 V H+ A+ VL R L ++ + GA RR Sbjct: 51 VSGHEEARAVLADGRFSSDKRKDGFPLFTLDAATLQQLRSQPPLMLGMDGAEHSAARRPV 110 Query: 129 MATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSY 188 + F + + L I + D + + + +D+ + + V +++ Y Sbjct: 111 IGEFTVKRLA--ALRPRIQDIVDHFIDDMLATDQRPVDLVQALSLPVPSLVICELLGVPY 168 Query: 189 KNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILE 248 + D + + + ++E + ++ ++ Sbjct: 169 TDHD--------FFQSRTTMMVS--------------RTSMEDRRRAFAELRAYIDDLIT 206 Query: 249 NYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTT 308 + + D L ++ D +++ + AG ETT Sbjct: 207 RKESEP--------GDDLFSRQIARQRQEGTLDHAG-------LVSLAFLLLTAGHETTA 251 Query: 309 SVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAP 368 +++ + LL +P+ + + + E+LR +A Sbjct: 252 NMISLGVVGLLSHPEQLTVVKANPGR------------------TPMAVEELLRYFTIAD 293 Query: 369 MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISP 428 + A D IG ++ G VI+++ + + + + P ER Sbjct: 294 GVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVER-----------G 342 Query: 429 SVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR---FDLEVPDDGQL 473 + +L FG GP C+G+ LAR EL ++ L +R L VP + Sbjct: 343 ARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRIPSLRLAVPMEDVP 390 >5LIE-A nrPDB Length = 414 Score = 168 bits (424), Expect = 8e-42, Method: Composition-based stats. Identities = 65/342 (19%), Positives = 116/342 (33%), Gaps = 63/342 (18%) Query: 123 LHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVF-VAVTNVISL 181 RRL + +++E + + L D + G D + +I + Sbjct: 105 RIRRLVSSGLT--PRMIRRVEDDLRRRARGLLDGVE--PGAPFDFVVEIAAELPMQMICI 160 Query: 182 ICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRND 241 + G+ + + P ++ + +V+ Sbjct: 161 LL--------------------GVPETDRHWLFEAVEPGFDFRGSRRATMPRLNVEDAGS 200 Query: 242 LLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFG 301 L R++ +ML + A + D D+ LSD + +F Sbjct: 201 RLYTYALELIAGKRAEPADDMLSVVANATI--------DDPDAPALSDAELYLFFHLLFS 252 Query: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361 AG ETT + + L L NP + L R+ LL I E++ Sbjct: 253 AGAETTRNSIAGGLLALAENPDQLQTL------------------RSDFELLPTAIEEIV 294 Query: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA 421 R +P A+ S+G ++ G +V++ + + + + + D+F R NP Sbjct: 295 RWTSPSPSK-RRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITRKPNP- 352 Query: 422 GTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 +L FG G C+G LAR EL ++ LL RF Sbjct: 353 ----------HLGFGQGVHYCLGANLARLELRVLFEELLSRF 384 >5IT1-A nrPDB Length = 399 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 66/396 (16%), Positives = 125/396 (31%), Gaps = 70/396 (17%) Query: 70 TKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNR--KGIAFADSGAHWQLHRRL 127 +V ++ + VL + T D + +G R+L Sbjct: 42 GHEAWLVTGYEQVRAVLRDPSFSVGVPHALHTQDGVVTQKPGRGSLLWQDAPEHTDDRKL 101 Query: 128 AMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTS 187 F + + Q L I + + D + G +D+ V +++ F Sbjct: 102 LAKEFTVRRM--QALRPNIQRIVDEHLDAIEA-RGGPVDLVKTFANPVPSMVISDLFGVP 158 Query: 188 YKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKIL 247 + E I + + + + L +L Sbjct: 159 AER-RAEFQEIAEAMMRVDQDAAATEAAGM------------------------RLGGLL 193 Query: 248 ENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETT 307 ++ R++ +++ L+ D D ++ D ++ G + A +TT Sbjct: 194 YQLVQERRANPGDDLISALIT----------TEDPDG-VIDDMFLMNAAGTLLIAAHDTT 242 Query: 308 TSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVA 367 ++ A LL P L ++ L+ + E+LR + Sbjct: 243 ACMIGLGTALLLDRPDQLALLQKDP------------------SLIGNAVEELLRYLTIG 284 Query: 368 PMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLIS 427 A D IG + KG +V+ +L + + P++F R P Sbjct: 285 QFGAERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDITRRPAP------- 337 Query: 428 PSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 +L FG G CIG+ LAR EL ++ L +RF Sbjct: 338 ----HLAFGFGAHQCIGQQLARIELQIVFGTLFRRF 369 >6A7I-A nrPDB Length = 411 Score = 166 bits (419), Expect = 3e-41, Method: Composition-based stats. Identities = 84/423 (19%), Positives = 149/423 (35%), Gaps = 82/423 (19%) Query: 61 GPIYSVRM-GTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDI--ASNNRKGIAFADS 117 GP+ V + G V H A+ +L + + I A+ Sbjct: 26 GPLAEVELPGGVHVYAVTRHAEARALLTD-SRVVKDIDVWNAWRRGEIPMDWPLIGLANP 84 Query: 118 GAHW-----QLHRRL-AMATFALFKDGDQKLEKIICQEISTLCDMLATHN-GQSIDISFP 170 G HRRL + AL ++L I + + LA G+ +D+ Sbjct: 85 GRSMLTVDGADHRRLRTLVAQALTVKRVERLRAGIEALTNASLEKLAALPAGEPVDLKAE 144 Query: 171 V-FVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTL 229 + NVIS + + ++ E + V Sbjct: 145 FAYPLPMNVISELM-----GVDAADHPRLKELFEKFFSTQTPPEEVP------------- 186 Query: 230 EKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSD 289 + L KI++ R++ ++ L+ A ++ + L+D Sbjct: 187 ----QMMADLGALFTKIVD----AKRTNPGDDLTSALIAAS-----------ENGDHLTD 227 Query: 290 NHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNR 349 I+ T+ I AG ETT S++ + L +P+ +KK+ ++ +G+ Sbjct: 228 EEIVNTLQLIIAAGHETTISLIVNVVEALQTHPEQRKKV---LNGEIGW----------- 273 Query: 350 LLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW-HQ 408 + I E LR ++ A D +G+ + KG +II+ AL +E+++ Sbjct: 274 ----DGVIEETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGALGRDEEQYGPT 329 Query: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF---DL 465 +F R N ++ FG GP C G L+R E + + L +RF DL Sbjct: 330 AGEFDATRTPN-----------RHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDL 378 Query: 466 EVP 468 VP Sbjct: 379 AVP 381 >5Y1I-A nrPDB Length = 403 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 76/471 (16%), Positives = 143/471 (30%), Gaps = 99/471 (21%) Query: 17 WPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIV 76 WP +R G + + L + + G+ V+ Sbjct: 8 WPMKRDTGCPFDPPP-------GVRKLLAEKPLSRA------------RIWDGSTPWVV- 47 Query: 77 GHHQLAKEVLIKKGKDFSGRPQMAT-----LDIASNNRKGIAFADSGAHWQLHRRLAMAT 131 H + +L G S + A D H ++ R M T Sbjct: 48 TRHADQRALLSDPRVSHDGLRDGYPHISADFKFLSMAQPSFAGQDDPEHGRIRR---MVT 104 Query: 132 FALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFV-AVTNVISLICFNTSYKN 190 + + I + L D + + +D+ + + VI + Sbjct: 105 LPFTARRIEAMRPAIQKITDELIDGMLAGP-KPVDLVEALALPVPVRVICEML---GVPY 160 Query: 191 GDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENY 250 D E +Q N +I + + + L+ Sbjct: 161 EDREF--LQQNNNAMIY---------------------RDTAQGDAQKAAIAQAMYLKEL 197 Query: 251 KEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSV 310 D ++L L + ++ + + GAG ETT ++ Sbjct: 198 VGTKLGDRGDDILSDLAVQVEAGE------------ITQDDAAGIGMMLLGAGHETTANM 245 Query: 311 VKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPML 370 + LL NP+ ++ D + ++ T+ E+LR +A Sbjct: 246 IALGTLALLENPEQLAEVR----------------DSDDPKVIVNTVEELLRYLTIAQDT 289 Query: 371 IPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ-PDQFMPERFLNPAGTQLISPS 429 + A D IG + G ++ L A + + + + PD+ R + + Sbjct: 290 VRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDIHR----------ANA 339 Query: 430 VSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480 +L FG G C+G LAR EL ++ + LL+R +P +L+ IP Sbjct: 340 RRHLAFGYGVHQCLGATLARVELQIVYSTLLRR----IPTLALAGTLDEIP 386 >3NC3-A nrPDB Length = 441 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 71/426 (16%), Positives = 145/426 (34%), Gaps = 59/426 (13%) Query: 39 SLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQ 98 S+ + + F +L+++ P++ + + + + + +L + F+ + Sbjct: 45 SVLSDQFQNNPYAYFSQLREE-DPVH--YEESIDSYFISRYHDVRYIL-QHPDIFTTKSL 100 Query: 99 MATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLA 158 + + + G RR+ + +F D L +I Q L Sbjct: 101 VERAEPVMRGP--VLAQMHGKEHSAKRRIVVRSF--IGDALDHLSPLIKQNAENLLAPYL 156 Query: 159 THNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLV 218 D+ T + + D E I ++ G+ D + Sbjct: 157 ERGKS--DLVNDFGK--TFAVCVTMDMLGLDKRDHE--KISEWHSGV---------ADFI 201 Query: 219 PWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNA 278 + P L ++ L+ I E R + ++++ L ++ Sbjct: 202 TSISQSPEARAHSLWCSEQLSQYLMPVIKER-----RVNPGSDLISILCTSEYE------ 250 Query: 279 GPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGF 338 LSD IL I ++ A E + + LL+NP+ + Sbjct: 251 -----GMALSDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDV---------- 295 Query: 339 SRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWA 398 L+ I E LR +P LIP + + D+ +G + K T V + A Sbjct: 296 --------LADRSLVPRAIAETLRYKPPV-QLIPRQLSQDTVVGGMEIKKDTIVFCMIGA 346 Query: 399 LHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAW 458 + + + + QPD F R + S + +L FG+G +C+G A+ E+ ++ Sbjct: 347 ANRDPEAFEQPDVFNIHR-EDLGIKSAFSGAARHLAFGSGIHNCVGTAFAKNEIEIVANI 405 Query: 459 LLQRFD 464 +L + Sbjct: 406 VLDKMR 411 >6B11-A nrPDB Length = 440 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 49/217 (22%), Positives = 83/217 (38%), Gaps = 35/217 (16%) Query: 260 TNMLDTLMQAKMNSDNGNA-----GPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314 + LD L+ K ++G+ LS +L + AG ETT S+V + Sbjct: 232 RDYLDRLISGKTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMS 291 Query: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHK 374 + LL +P ++L LL + E+LR +A + Sbjct: 292 VLVLLQHPTAWRELT------------------VNPGLLPGAVDELLRYLSIAD-GLRRS 332 Query: 375 ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLP 434 A D I + G ++ L A + +E + +P+ F R + ++ Sbjct: 333 ATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHR-----------SARRHVA 381 Query: 435 FGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDG 471 FG GP C+G+ LAR EL + + +L+R P Sbjct: 382 FGYGPHQCLGQNLARMELEVALGAVLERLPALRPTTD 418 >3TYW-A nrPDB Length = 417 Score = 165 bits (417), Expect = 5e-41, Method: Composition-based stats. Identities = 76/394 (19%), Positives = 144/394 (36%), Gaps = 76/394 (19%) Query: 75 IVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFAD----SGAHWQLHRRLAMA 130 +V + +E+L R G F +RR+ + Sbjct: 57 VVTRYDDVRELLSDPRVSADIRRPGFPALGEGEQEAGARFRPFIRTDAPEHTRYRRMLLP 116 Query: 131 TFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTN-VISLICFNTSYK 189 F + + + + + + + D + G +D+ AV+ VI Sbjct: 117 AFTVRR--VRAMRPAVQARVDEILDGMLAAGG-PVDLVSAYANAVSTSVIC--------- 164 Query: 190 NGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILEN 249 EL I ++ ++++ S N T E++ + LL ++ Sbjct: 165 ----ELLGIPRHDLEFFRDVTRISGS---------RNSTAEQVSEALGGLFGLLGGLVAE 211 Query: 250 YKEKFRSDSITNML-DTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTT 308 +E+ R D I+ ++ D L+ + + +L+T+G AG ETTT Sbjct: 212 RREEPRDDLISKLVTDHLVPGNV----------------TTEQLLSTLGITINAGRETTT 255 Query: 309 SVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAP 368 S++ + LL P++ +L ++ D L+ A + E+LR+ VA Sbjct: 256 SMIALSTLLLLDRPELPAELRKDPD------------------LMPAAVDELLRVLSVAD 297 Query: 369 MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISP 428 + A D + V VI L +H+ +++ P++ R N Sbjct: 298 SIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHRTDN--------- 348 Query: 429 SVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 ++ FG G C+G+ LAR EL + + LL+R Sbjct: 349 --HHVAFGYGVHQCVGQHLARLELEVALETLLRR 380 >4OQS-A nrPDB Length = 433 Score = 165 bits (417), Expect = 5e-41, Method: Composition-based stats. Identities = 78/425 (18%), Positives = 138/425 (32%), Gaps = 92/425 (21%) Query: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQ---------LHRR 126 V H A+ V+I FS RP+ + R G A W +RR Sbjct: 50 VTSHAAARTVMIDPR--FSNRPEHKHPVFSVIPRPGGATKAPAPGWFINMDAPEHTRYRR 107 Query: 127 LAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNT 186 + ++ F + + ++LE I Q D +A G +D+ + V +++ Sbjct: 108 MLISQFTVRR--IKELEPRIVQITEDHLDAMAKA-GPPVDLVQAFALPVPSLVICELLGV 164 Query: 187 SYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKI 246 SY + + +++K + V L + Sbjct: 165 SYAD------------HAFFQEQTTI-------------MASVDKTQDEVTTALGKLTRY 199 Query: 247 LENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVET 306 + R ++L +L+ L+D + + AG ET Sbjct: 200 IAELVATKRLSPKDDLLGSLIT---------------DTDLTDEELTNIALLLLVAGHET 244 Query: 307 TTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPV 366 T +++ LL +P+ L + E+LR + Sbjct: 245 TANMLGLGTFALLQHPEQIAALDS-----------------------PDAVEELLRYLSI 281 Query: 367 APMLIP-HKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQL 425 + P A D + + KG V I L A++ + K + +PD +R Sbjct: 282 VHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR--------- 332 Query: 426 ISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF---DLEVP-DDGQLPSLEGIPK 481 + + FG G C+G+ LAR E+ + L RF L VP ++ +L Sbjct: 333 -VDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKLREKSAAYG 391 Query: 482 VVFLI 486 V L Sbjct: 392 VWALP 396 >4WPZ-A nrPDB Length = 397 Score = 165 bits (417), Expect = 5e-41, Method: Composition-based stats. Identities = 75/407 (18%), Positives = 131/407 (32%), Gaps = 83/407 (20%) Query: 75 IVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADS-----GAHWQLHRRLAM 129 +V H ++VL+ FS + S G +S R+L Sbjct: 41 MVTKHADVRKVLVD--SRFSSKVMATAAAAMSETETGKLMNESLVGMDAPEHTRLRKLVT 98 Query: 130 ATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFV-AVTNVISLICFNTSY 188 F + L I + + L D L T + +D+ V VI + Sbjct: 99 KAFT--ARRVETLRPRITELVGQLLDELETLP-RPVDLVKNFSVPLPVRVICELL---GV 152 Query: 189 KNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILE 248 GD D S L W ++ + + +++ Sbjct: 153 PAGDQ-------------DTFHAWSNALLGDWQQVVEKEA------ATVSLVNYFGELIA 193 Query: 249 NYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTT 308 +E + +++ L+ L++ I+ I AG ETT Sbjct: 194 VKRE----NPADDLISELIAIS-----------DGDSTLTEREIIALSIGILSAGHETTA 238 Query: 309 SVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAP 368 + + L LLHNP+ KL + + + + E+LR P+ Sbjct: 239 NQISMFLVTLLHNPEELDKLRDNREA------------------IPKAVDELLRFVPLTT 280 Query: 369 M--LIPHKANVDSSI-GEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQL 425 +IP + + G + G V+ + + + + + ++ R NP Sbjct: 281 TGGIIPRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLNVTRENNP----- 335 Query: 426 ISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF---DLEVPD 469 +L FGAG C+G LAR EL + +L R L VP+ Sbjct: 336 ------HLAFGAGIHHCLGAQLARIELQEALGAILDRMPQVRLAVPE 376 >3ABA-A nrPDB Length = 403 Score = 164 bits (416), Expect = 6e-41, Method: Composition-based stats. Identities = 66/409 (16%), Positives = 124/409 (30%), Gaps = 96/409 (23%) Query: 70 TKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLH----- 124 +V ++ + +L + T D + G WQ Sbjct: 42 GHEAWLVTGYEEVRALLRDSSFSVQVPHALHTQDGVVTQKPG----RGSLLWQDEPEHTS 97 Query: 125 -RRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLIC 183 R+L F + + Q L I + + D + G +D+ AV +++ Sbjct: 98 DRKLLAKEFTVRRM--QALRPNIQRIVDEHLDAIEA-RGGPVDLVKTFANAVPSMVISDL 154 Query: 184 FNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLL 243 F + D+ Sbjct: 155 FGVPVE---------------------------------------------RRAEFQDIA 169 Query: 244 NKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNH---------ILT 294 ++ ++ +++ L L+ + N G D S L++ ++ Sbjct: 170 EAMMRVDQDAAATEAAGMRLGGLLYQLVQERRANPGDDLISALITTEDPDGVVDDMFLMN 229 Query: 295 TIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLE 354 G + A +TT ++ A LL +P L E+ L+ Sbjct: 230 AAGTLLIAAHDTTACMIGLGTALLLDSPDQLALLREDP------------------SLVG 271 Query: 355 ATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMP 414 + E+LR + A D +G + KG +V+ ++ A + +P++F Sbjct: 272 NAVEELLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDI 331 Query: 415 ERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 R P +L FG G CIG+ LAR EL ++ L +R Sbjct: 332 TRRPAP-----------HLAFGFGAHQCIGQQLARIELQIVFETLFRRL 369 >1GWI-A nrPDB Length = 411 Score = 164 bits (416), Expect = 6e-41, Method: Composition-based stats. Identities = 78/424 (18%), Positives = 140/424 (33%), Gaps = 85/424 (20%) Query: 61 GPIYSVRM-GTKTTVIVGHHQLAKEVLIKKGKDFS-------GRPQMA---TLDIASNNR 109 GP+ +V + G V HH AK +L R ++ L +N Sbjct: 30 GPLAAVELPGGVPVWAVTHHAEAKALLTDPRLVKDINVWGAWRRGEIPADWPLIGLANPG 89 Query: 110 KGIAFADSGAHWQLHRRL-AMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDIS 168 + + D HRRL + AL + + I + L D L G + Sbjct: 90 RSMLTVDGAE----HRRLRTLVAQALTVRRVEHMRGRITELTDRLLDELPADGGVVDLKA 145 Query: 169 FPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKT 228 + V++ + + L ++ E + Sbjct: 146 AFAYPLPMYVVADLM-----GIEEARLPRLKVLFEKFFSTQTPP---------------- 184 Query: 229 LEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLS 288 V L I+ + R+ ++ L+QA ++ + L+ Sbjct: 185 -----EEVVATLTELASIMTDTVAAKRAAPGDDLTSALIQAS-----------ENGDHLT 228 Query: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348 D I++T+ + AG ETT S++ + L +P+ + + + Sbjct: 229 DAEIVSTLQLMVAAGHETTISLIVNAVVNLSTHPEQRALVLSGEAEW------------- 275 Query: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW-H 407 A + E LR ++ A D +G+ + G +I++ AL +E+ Sbjct: 276 -----SAVVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGP 330 Query: 408 QPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF---D 464 D+F R + ++ FG GP C G L+R E + + L RF D Sbjct: 331 TADRFDLTR----------TSGNRHISFGHGPHVCPGAALSRMEAGVALPALYARFPHLD 380 Query: 465 LEVP 468 L VP Sbjct: 381 LAVP 384 >3R9C-A nrPDB Length = 418 Score = 164 bits (415), Expect = 9e-41, Method: Composition-based stats. Identities = 74/411 (18%), Positives = 128/411 (31%), Gaps = 78/411 (18%) Query: 88 KKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIIC 147 + R A F D H R + + A ++LE I Sbjct: 73 RTKSTIFQRQLAAETQPRPQGPASFLFLDPPDH---TRLRGLVSKAFAPRVIKRLEPEIT 129 Query: 148 QEISTLCDMLATHNGQSID-ISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGII 206 + L D + ID +++P+ VA VI + Sbjct: 130 ALVDQLLDAVDGPEFNLIDNLAYPLPVA---VICRLLGVPIEDEPKFSRASALLAAALDP 186 Query: 207 DNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTL 266 DL ++ D L +++ + +++ L Sbjct: 187 FLALTGETSDLF-----------DEQMKAGMWLRDYLRALIDERRRT----PGEDLMSGL 231 Query: 267 MQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKK 326 + ++ + L+++ I+ T + AG ETT +++ +L P Sbjct: 232 VAV-----------EESGDQLTEDEIIATCNLLLIAGHETTVNLIANAALAMLRTPGQWA 280 Query: 327 KLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAV 386 L + + A I E +R P L+ A D +IG V Sbjct: 281 ALAADGSRA------------------SAVIEETMRYDPPV-QLVSRYAGDDLTIGTHTV 321 Query: 387 DKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEI 446 KG +++ L A H + PD+F P+R + +L FG G C+G Sbjct: 322 PKGDTMLLLLAAAHRDPTIVGAPDRFDPDR-----------AQIRHLGFGKGAHFCLGAP 370 Query: 447 LARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQ 497 LAR E + + L RF L G P+ +K + +R Sbjct: 371 LARLEATVALPALAARF--------PEARLSGEPE-------YKRNLTLRG 406 >5NWS-A nrPDB Length = 435 Score = 164 bits (414), Expect = 9e-41, Method: Composition-based stats. Identities = 78/466 (16%), Positives = 144/466 (30%), Gaps = 90/466 (19%) Query: 39 SLPFLPRHGHMHNNFFKLQKKYGPIYSVRM-GTKTTVIVGHHQLAKEVLIKKGKDFSGRP 97 + + +L+++ GP+ R V + + VL F P Sbjct: 26 HMMDPDLLADPFTGYGRLRER-GPVVRGRFVDGTPVWFVTRYDDVRAVLRDPR--FVNTP 82 Query: 98 QMATLDIASNNRKGI-----------------AFADSGAHWQLHRRLAMATFALFKDGDQ 140 + ++ R+G+ RRL FA Sbjct: 83 SPVPGEGGADPREGMMDLLNVPEPLRVYLLGSILDSDPPDHPRLRRLVTRAFA--ARRIL 140 Query: 141 KLEKIICQEISTLCDML---ATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNV 197 L I + L L +G + + VI + Sbjct: 141 GLRPGIERIADRLLAELPRREEEDGTVDLLEHFAYPLSITVICELV-------------- 186 Query: 198 IQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSD 257 + L W + E+L+ + D ++++E + Sbjct: 187 ----------GIPATDLERWREWGGDLVSMRPERLRHSFPVMIDYCHRLIEQRRAALT-- 234 Query: 258 SITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAF 317 ++L L++A+ D D LSD +T I + AG ET+ ++ A Sbjct: 235 --DDLLSELIRAQ----------DDDGGRLSDIETVTMILTLVLAGHETSAHLIGNGTAA 282 Query: 318 LLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANV 377 LL +P L ++ LL + E++R + A Sbjct: 283 LLTHPGQWALLRKDP------------------ALLPRAVHELMRWCGSVHVARLRYATE 324 Query: 378 DSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGA 437 D + V +G V + L + + + + + PD+ R + +++ FG Sbjct: 325 DLELAGTPVARGDAVQLVLVSANFDPRHYSDPDRLDITR-------HQEGQAENHVGFGH 377 Query: 438 GPRSCIGEILARQELFLIMAWLLQRF-DLEVPDDGQLPSLEGIPKV 482 G C+G LARQE + +A LL+ + DL + D +P Sbjct: 378 GIHYCLGATLARQEGEVALARLLETYPDLALADGDPEVRRARLPGS 423 >4OQR-A nrPDB Length = 457 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 77/425 (18%), Positives = 139/425 (32%), Gaps = 92/425 (21%) Query: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQ---------LHRR 126 V H A+ V+I FS RP+ + R G A W +RR Sbjct: 89 VTSHAAARTVMIDPR--FSNRPEHKHPVFSVIPRPGGATKAPAPGWFTNMDAPEHTRYRR 146 Query: 127 LAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNT 186 + ++ F + + ++LE I + D +A G +D+ + V +++ Sbjct: 147 MLISQFTVRR--IKELEPRIVRITEDHLDAMAKA-GPPVDLVQAFALPVPSLVICELLGV 203 Query: 187 SYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKI 246 SY + + + +++K + V L + Sbjct: 204 SYAD------------HAFFQEQTTIMV-------------SVDKTQDEVTTALGKLTRY 238 Query: 247 LENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVET 306 + R ++L +L+ L+D + + AG ET Sbjct: 239 IAELVATKRLSPKDDLLGSLIT---------------DTDLTDEELTNIALILLVAGHET 283 Query: 307 TTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPV 366 T +++ LL +P+ L + E+LR + Sbjct: 284 TANMLGLGTFALLQHPEQIANLDS-----------------------PDAVEELLRYLSI 320 Query: 367 APMLIP-HKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQL 425 + P A D + + KG V I L A++ + K + +PD +R Sbjct: 321 VHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR--------- 371 Query: 426 ISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF---DLEVP-DDGQLPSLEGIPK 481 + + FG G C+G+ LAR E+ + L RF L VP ++ +L Sbjct: 372 -VDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKLREKSAAYG 430 Query: 482 VVFLI 486 V L Sbjct: 431 VWALP 435 >5XJN-A nrPDB Length = 455 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 57/398 (14%), Positives = 130/398 (32%), Gaps = 73/398 (18%) Query: 75 IVGHHQLAKEVLIKKGKDFSG---------RPQMATLDIASNN--RKGIAFADSGAHWQL 123 +V + K + FS R AT + A Sbjct: 87 VVTKYDDIKTTF-DDWETFSSENAQAPVRKRGPQATQIMTDGGFTAYSGLSARIPPEHTR 145 Query: 124 HRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLIC 183 R +A F + LE I + + + ++ D+ + + + L Sbjct: 146 IRAIAQKAFT--PRRYKALEPDIRAMVIDRVEKMLANDQHVGDMVSDLAYDIPTITILTL 203 Query: 184 FNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLL 243 D + + W + + + + V+ + Sbjct: 204 IGADISMVDTYKRWSDSRA--------------AMTWGDLSDEEQIPHAHNLVEYWQE-C 248 Query: 244 NKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAG 303 +++ + + +++ Q+ + ++D+ I + + + AG Sbjct: 249 QRMVADAHAHGGDNLTADLV---------------RAQQEGQEITDHEIASLLYSLLFAG 293 Query: 304 VETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRL 363 ETTT+++ LL +P+ + + E L+ A + EVLR Sbjct: 294 HETTTTLISNCFRVLLDHPEQWQAILENPK------------------LIPAAVDEVLRY 335 Query: 364 RPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGT 423 + + KA D+ IG A+ +G V++ + + + +E + ++F R Sbjct: 336 -SGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFDISR------- 387 Query: 424 QLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQ 461 + + +L FG G C+G +LA+ + + + + + Sbjct: 388 ---ANAREHLSFGFGIHYCLGNMLAKLQAKICLEEVTR 422 >5GWE-A nrPDB Length = 405 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 57/398 (14%), Positives = 130/398 (32%), Gaps = 73/398 (18%) Query: 75 IVGHHQLAKEVLIKKGKDFSG---------RPQMATLDIASNN--RKGIAFADSGAHWQL 123 +V + K + FS R AT + A Sbjct: 37 VVTKYDDIKTTF-DDWETFSSENAQAPVRKRGPQATQIMTDGGFTAYSGLSARIPPEHTR 95 Query: 124 HRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLIC 183 R +A F + LE I + + + ++ D+ + + + L Sbjct: 96 IRAIAQKAFT--PRRYKALEPDIRAMVIDRVEKMLANDQHVGDMVSDLAYDIPTITILTL 153 Query: 184 FNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLL 243 D + + W + + + + V+ + Sbjct: 154 IGADISMVDTYKRWSDSRA--------------AMTWGDLSDEEQIPHAHNLVEYWQE-C 198 Query: 244 NKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAG 303 +++ + + +++ Q+ + ++D+ I + + + AG Sbjct: 199 QRMVADAHAHGGDNLTADLV---------------RAQQEGQEITDHEIASLLYSLLFAG 243 Query: 304 VETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRL 363 ETTT+++ LL +P+ + + E L+ A + EVLR Sbjct: 244 HETTTTLISNCFRVLLDHPEQWQAILENPK------------------LIPAAVDEVLRY 285 Query: 364 RPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGT 423 + + KA D+ IG A+ +G V++ + + + +E + ++F R Sbjct: 286 -SGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFDISR------- 337 Query: 424 QLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQ 461 + + +L FG G C+G +LA+ + + + + + Sbjct: 338 ---ANAREHLSFGFGIHYCLGNMLAKLQAKICLEEVTR 372 >2WIO-A nrPDB Length = 431 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 72/428 (16%), Positives = 138/428 (32%), Gaps = 72/428 (16%) Query: 37 VGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGR 96 + +P + + + +++K P++ R G V H + VL FS Sbjct: 38 IDEVPGMADETALLDWLGTMREKQ-PVWQDRYG---VWHVFRHADVQTVLRDTA-TFSSD 92 Query: 97 PQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDM 156 P + ++ G+ + R++ + F LE I +L Sbjct: 93 PTR--VIEGASPTPGMIHEIDPPEHRALRKVVSSAFT--PRTISDLEPRIRDVTRSLL-- 146 Query: 157 LATHNGQSIDISFPV-FVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLV 215 G+S D+ + F +++ + + +LV Sbjct: 147 --ADAGESFDLVDVLAFPLPVTIVAELLGLPPMDHE--------------QFGDWSGALV 190 Query: 216 DLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDN 275 D+ + T L + + L L+ + R+D +++ L+ A++ Sbjct: 191 DI-----QMDDPTDPALAERIADVLNPLTAYLKARCAERRADPGDDLISRLVLAEV---- 241 Query: 276 GNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQN 335 D L D + AG TTT ++ + L +P E+ + Sbjct: 242 -------DGRALDDEEAANFSTALLLAGHITTTVLLGNIVRTLDEHPAHWDAAAEDPGR- 293 Query: 336 VGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIIN 395 + A + EVLR RP P + + + + V Sbjct: 294 -----------------IPAIVEEVLRYRPPFPQMQ-RTTTKATEVAGVPIPADVMVNTW 335 Query: 396 LWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLI 455 + + + + PD+F P R S + L FG G C+G LAR E + Sbjct: 336 VLSANRDSDAHDDPDRFDPSR---------KSGGAAQLSFGHGVHFCLGAPLARLENRVA 386 Query: 456 MAWLLQRF 463 + ++ RF Sbjct: 387 LEEIIARF 394 >4TRI-A nrPDB Length = 407 Score = 161 bits (406), Expect = 8e-40, Method: Composition-based stats. Identities = 76/443 (17%), Positives = 146/443 (32%), Gaps = 87/443 (19%) Query: 62 PIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHW 121 P++ R G +Q + + + FS + + D H Sbjct: 35 PVFRDRNG---LAAATTYQAVLDA-ERNPELFSSTGGIRPDQ---PGMPYMIDMDDPQH- 86 Query: 122 QLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLAT---HNGQ---SIDISFPVFVAV 175 L RR + +++ + I LCD L G+ DI+ P+ +AV Sbjct: 87 -LLRRKLV----NAGFTRKRVMDKV-DSIGRLCDTLIDAVCERGECDFVRDIAAPLPMAV 140 Query: 176 TNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSH 235 + + E +++ +++ ++ LS ++KL Sbjct: 141 IGDMLGVL--------PTERDMLLKWSDDLVCGLSS-----------HVDEAAIQKLMDT 181 Query: 236 VKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTT 295 + ++ + + ++ L+ +++ + +SD+ I+ Sbjct: 182 FAAYTEFTKDVITKRRA----EPTDDLFSVLVNSEVE-----------GQRMSDDEIVFE 226 Query: 296 IGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEA 355 I G ETT + LL + L ++D LL Sbjct: 227 TLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVD------------------LLPG 268 Query: 356 TIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPE 415 I E+LR + D+ + G ++++ + + +E + PD F + Sbjct: 269 AIEEMLRWTSPVKNMC-RTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRID 327 Query: 416 RFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF-DLEVPDDGQLP 474 R N S++ FG G C+G LAR EL L+ +L+R DL + DD +P Sbjct: 328 RNPN-----------SHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDAPVP 376 Query: 475 SLEGIPKVVFLIDSFKVKIKVRQ 497 V +S V Sbjct: 377 LRPANF--VSGPESMPVVFTPSA 397 >5FOI-A nrPDB Length = 408 Score = 161 bits (406), Expect = 1e-39, Method: Composition-based stats. Identities = 63/399 (15%), Positives = 132/399 (33%), Gaps = 73/399 (18%) Query: 65 SVRMGTKTTVIVGHHQLAKEVLIKKGKDF-SGRPQMATLDIASNNRKGIAFADSGAHWQL 123 V G+ T +V ++ + +L+ R + + Sbjct: 51 KVWDGS-PTWLVSRYEHVRALLVDPRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHTR 109 Query: 124 HRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLIC 183 RR+ ++ F++ + + I + + + D L ++ T VI + Sbjct: 110 LRRMFISAFSV--RQVETMRPEIEKIVDGILDRLLALEPPVDILTHLALPMSTQVICHLL 167 Query: 184 FNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLL 243 D E Q +E L PN + + L Sbjct: 168 ---GVPYEDREF--FQERSE-----------------LASRPNDDRSM--PALIELVEYL 203 Query: 244 NKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAG 303 + ++ + +L T + ++ ++ ++ + AG Sbjct: 204 DGLVRTKTAHPDTG----LLGTAVTERLLKGE-----------ITHQELVNNAVLLLAAG 248 Query: 304 VETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRL 363 ET+ + V ++ LL +P+ +L E+ + L+ + E+LR Sbjct: 249 HETSANQVTLSVLTLLRHPETAAELREQPE------------------LMPNAVDELLRY 290 Query: 364 RPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGT 423 +A + A D +G+ + G +II L + +H+ + F R Sbjct: 291 HSIAD-GLRRAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHR------- 342 Query: 424 QLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 P+ ++ FG GP C+G+ LAR E+ + + L +R Sbjct: 343 ----PARHHVAFGYGPHQCLGQNLARLEMEVTLGKLFRR 377 >3SN5-A nrPDB Length = 491 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 83/494 (16%), Positives = 167/494 (33%), Gaps = 55/494 (11%) Query: 20 RRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHH 79 RR + P +P +G + Q+K+G +++ ++ K + + Sbjct: 8 RRRQTGEPPLENGLIPYLGCALQFG--ANPLEFLRANQRKHGHVFTCKLMGKYVHFITNP 65 Query: 80 QLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGD 139 +VL GK F + L + + I D ++ L Sbjct: 66 LSYHKVLC-HGKYFDWKKFHFALSAKAFGHRSIDPMDGNTTENINDTFIK---TLQGHAL 121 Query: 140 QKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQ 199 L ++ + L + + VT + C+ ++ G + Sbjct: 122 NSL-------TESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRD 174 Query: 200 NYNEGIIDNLSKDSLVDLVPWLKIFP----NKTLEKLKSHVKIRNDLLNKILENYKEKFR 255 ++L + + K+FP + ++ R L + +K Sbjct: 175 LTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRE 234 Query: 256 SDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTL 315 S + L+ +M ++ + D D T + A T W+L Sbjct: 235 S------ISELISLRMFLNDTLSTFD-------DLEKAKTHLVVLWASQANTIPATFWSL 281 Query: 316 AFLLHNPQVKKKLYEEID-------QNVGFSRTPTI---SDRNRLLLLEATIREVLRLRP 365 ++ NP+ K EE+ Q V P ++ N L +L++ I+E LRL Sbjct: 282 FQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSS 341 Query: 366 VAPMLIPHKANVDSSI----GEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA 421 + + A D ++ G + + K + + +H + + + P F +R+L+ Sbjct: 342 ASLNI--RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDEN 399 Query: 422 GTQL-------ISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE-VPDDGQL 473 G + Y+PFG+G C G + A E+ + +L F+LE + + Sbjct: 400 GKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKC 459 Query: 474 PSL-EGIPKVVFLI 486 P L + + L Sbjct: 460 PPLDQSRAGLGILP 473 >1Z8P-A nrPDB Length = 404 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 71/414 (17%), Positives = 138/414 (33%), Gaps = 81/414 (19%) Query: 62 PIYSVRMGTKTTVIVGHHQLAKEVLIK------KGKDFSGRPQMATLDIASNNRKGIAFA 115 P+ VR + +V + AK L K + G + FA Sbjct: 28 PVTPVRFLGQDAWLVTGYDEAKAALSDLRLSSDPKKKYPGVEVEFPAYLGFPEDVRNYFA 87 Query: 116 DS-----GAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISF- 169 + R+L F + + + + + Q + L D + +DI Sbjct: 88 TNMGTSDPPTHTRLRKLVSQEFTVRR--VEAMRPRVEQITAELLDEVGDSG--VVDIVDR 143 Query: 170 PVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTL 229 VI EL + G + S L + P + Sbjct: 144 FAHPLPIKVIC-------------ELLGVDEKYRG---EFGRWS----SEILVMDPERAE 183 Query: 230 EKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSD 289 ++ ++ ++ N +L+ + E+ R++ ++L L++ + D D LS Sbjct: 184 QRGQAAREVVNFILDLV-----ERRRTEPGDDLLSALIRVQ----------DDDDGRLSA 228 Query: 290 NHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNR 349 + + + + AG E++ S++ LL +P + + Sbjct: 229 DELTSIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVRRDPSA--------------- 273 Query: 350 LLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQP 409 L + E+LR P A + IG A+ + + V++ A + + K++ P Sbjct: 274 ---LPNAVEEILRYIAP-PETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDP 329 Query: 410 DQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 +F R + +L FG G C+G LA+ E + + L RF Sbjct: 330 HRFDVTR-----------DTRGHLSFGQGIHFCMGRPLAKLEGEVALRALFGRF 372 >1F4U-A nrPDB Length = 368 Score = 158 bits (399), Expect = 5e-39, Method: Composition-based stats. Identities = 68/297 (22%), Positives = 124/297 (41%), Gaps = 40/297 (13%) Query: 195 LNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKF 254 L+ I + I+ L+ + ++ + P + EK K +DL+ L E F Sbjct: 107 LDSIDPREDDIVKKLAVPLPIIVISKILGLPIEDKEKFKEW----SDLVAFRLGKPGEIF 162 Query: 255 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314 L ++ +NS + LSD L I + AG ETTT+++ + Sbjct: 163 ELGKKYLELIGYVKDHLNS-GTEVVSRVVNSNLSDIEKLGYIILLLIAGNETTTNLISNS 221 Query: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHK 374 + + +++ EE L L+A I E LR P M K Sbjct: 222 VIDFTRF-NLWQRIREE------------------NLYLKA-IEEALRYSPPV-MRTVRK 260 Query: 375 ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLP 434 +G+ +++G V + + + + +E+ +H ++F+P+R NP +L Sbjct: 261 TKERVKLGDQTIEEGEYVRVWIASANRDEEVFHDGEKFIPDRNPNP-----------HLS 309 Query: 435 FGAGPRSCIGEILARQELFLIMAWLLQRFD-LEVPDDGQLPS--LEGIPKVVFLIDS 488 FG+G C+G LAR E + + +RF +E+ D ++P+ L G ++V + S Sbjct: 310 FGSGIHLCLGAPLARLEARIAIEEFSKRFRHIEILDTEKVPNEVLNGYKRLVVRLKS 366 >5EX6-C nrPDB Length = 434 Score = 158 bits (399), Expect = 6e-39, Method: Composition-based stats. Identities = 68/423 (16%), Positives = 130/423 (30%), Gaps = 83/423 (19%) Query: 61 GPIYSVRMGT----KTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRK------ 110 G + VR+G+ + T + H + ++VL + FS R + D Sbjct: 62 GELTRVRLGSGADAEHTWLATGHDVVRQVLGDHTR-FSTRRRFDRNDEIGGKGVFRPREL 120 Query: 111 -GIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISF 169 G RRL F K +++ I Q ++ D + G D+ Sbjct: 121 VGNLMDYDPPEHTRLRRLLAPGFTHRK--IRRMAPYIEQIVTERLDEMERE-GSPADLIE 177 Query: 170 PVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTL 229 V + + L + + + + Sbjct: 178 LFADEVPGPVLCELLGVPRDDRAMFLQLCHRHLDASLSG--------------------- 216 Query: 230 EKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSD 289 + ++ L + R D ++ ++ + + ++D Sbjct: 217 ----RRRAAAGEAFSRYLVTMVARERKDPGDGLIGMVVA-------------EHGDTVTD 259 Query: 290 NHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNR 349 + + AG + + ++ + LL NP+ L R Sbjct: 260 EELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAAL------------------RGD 301 Query: 350 LLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQP 409 + E + E++R V P A DS++G+ + G V+ +L + + Sbjct: 302 VPAAERAVDELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDA 361 Query: 410 DQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF-DLEVP 468 D+ R P ++ FG G C+G LAR EL + L +RF DL + Sbjct: 362 DRLDVTREAVP-----------HVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLA 410 Query: 469 DDG 471 D Sbjct: 411 DPD 413 >1EHE-A nrPDB Length = 403 Score = 158 bits (399), Expect = 6e-39, Method: Composition-based stats. Identities = 68/439 (15%), Positives = 138/439 (31%), Gaps = 84/439 (19%) Query: 45 RHGHMHNNFFKLQKKYGPIYSVRMG----------TKTTVIVGHHQLAKEVLIKKGKDFS 94 F KL+ P+ V++ K V + +V ++G Sbjct: 14 SGPEPPAEFAKLRAT-NPVSQVKLFDGSLAWLVTKHKDVCFVATSEKLSKVRTRQGF--- 69 Query: 95 GRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLC 154 P+++ + K R + TF + + L+ I + + L Sbjct: 70 --PELSASGKQAAKAKPTFVDMDPPEHMHQRSMVEPTFT--PEAVKNLQPYIQRTVDDLL 125 Query: 155 DMLATHN--GQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKD 212 + + +D+ + V + I + + L + N Sbjct: 126 EQMKQKGCANGPVDLVKEFALPVPSYIIYTLLGVPFND----LEYLTQQN---------- 171 Query: 213 SLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMN 272 ++ + T + + + D L ++ E+ + +++ L ++ Sbjct: 172 -------AIRTNGSSTAREASAANQELLDYLAILV----EQRLVEPKDDIISKLCTEQVK 220 Query: 273 SDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEI 332 N + + + AG T +++ +A L +P +L Sbjct: 221 PGNIDKSDA-----------VQIAFLLLVAGNATMVNMIALGVATLAQHPDQLAQL---- 265 Query: 333 DQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEV 392 + L + E+ R + + I A D IG+ V + Sbjct: 266 --------------KANPSLAPQFVEELCRYHTASALAIKRTAKEDVMIGDKLVRANEGI 311 Query: 393 IINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQEL 452 I + + + +E+ + PD+F R P L FG G CI E LA+ EL Sbjct: 312 IASNQSANRDEEVFENPDEFNMNRKWPPQDP---------LGFGFGDHRCIAEHLAKAEL 362 Query: 453 FLIMAWLLQRF-DLEVPDD 470 + + L Q+F DL+V Sbjct: 363 TTVFSTLYQKFPDLKVAVP 381 >1UED-A nrPDB Length = 406 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 74/442 (16%), Positives = 140/442 (31%), Gaps = 84/442 (19%) Query: 42 FLPRHGHMHNNFFKLQKKYGPIYSV------RMGTKTTVIVGHHQLAKEVLIKKGKDFSG 95 L + H + F L+ +GP+ + ++G +++ + +L + F+ Sbjct: 19 QLRTNCDPHEDNFGLRA-HGPLVRIVGESSTQLGRDFVWQAHGYEVVRRILGDH-EHFTT 76 Query: 96 RPQMATLDIASNNRK---GIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEIST 152 RPQ ++ G R++ F + + +++E I I Sbjct: 77 RPQFTQSKSGAHVEAQFVGQISTYDPPEHTRLRKMLTPEFTVRR--IRRMEPAIQSLIDD 134 Query: 153 LCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKD 212 D+L G S D+ V + + I+ Sbjct: 135 RLDLLEAE-GPSADLQGLFADPVGAHALCELLGIPRDDQREFVRRIRR------------ 181 Query: 213 SLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMN 272 N L + + N+ L+N + R+D +L ++ Sbjct: 182 -------------NADLSRGLKARAADSAAFNRYLDNLLARQRADPDDGLLGMIV----- 223 Query: 273 SDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEI 332 + ++D + + GVET ++ + + LL NP + L+E Sbjct: 224 --------RDHGDNVTDEELKGLCTALILGGVETVAGMIGFGVLALLDNPGQIELLFESP 275 Query: 333 DQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEV 392 ++ E + E++R P A D I + G V Sbjct: 276 EKA------------------ERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYV 317 Query: 393 IINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQEL 452 + ++ + +E PD R +VS + FG G C+G LAR L Sbjct: 318 LCSILMANRDEALTPDPDVLDANR-----------AAVSDVGFGHGIHYCVGAALARSML 366 Query: 453 FLIMAWLLQRF---DLEVPDDG 471 + L +RF L VP + Sbjct: 367 RMAYQTLWRRFPGLRLAVPIEE 388 >3P3Z-A nrPDB Length = 416 Score = 156 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 62/343 (18%), Positives = 107/343 (31%), Gaps = 63/343 (18%) Query: 123 LHRRLA-MATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISL 181 HRRL +AT ++ + + L D L G + V+ Sbjct: 107 DHRRLRGLATHPFTPRRITAVQPFVRSTVEQLIDKLP--QGDFDFVQHFPHPLPALVMCQ 164 Query: 182 ICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRND 241 + + D + + + LS D + + K++ + D Sbjct: 165 LL---GFPLEDYDTVGRLSIETNLGLALSNDQDILV-------------KVEQGLGRMFD 208 Query: 242 LLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFG 301 L +E K + D ++++ +L D + T + + Sbjct: 209 YLVAAIEKRKVEPGDDLTSDIVRAF----------------HDGVLDDYELRTLVATVLV 252 Query: 302 AGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVL 361 AG ETT + + +P K+ E + L + EVL Sbjct: 253 AGYETTNHQLALAMYDFAQHPDQWMKIKENPE------------------LAPQAVEEVL 294 Query: 362 RLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA 421 R P P+ A D + + GT V + H + + + D+F Sbjct: 295 RWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADADRFDIT------ 348 Query: 422 GTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFD 464 + + FG GP C+G LAR EL +A L R D Sbjct: 349 ----VKREAPSIAFGGGPHFCLGTALARLELTEAVAALATRLD 387 >4XE3-A nrPDB Length = 407 Score = 155 bits (392), Expect = 4e-38, Method: Composition-based stats. Identities = 76/439 (17%), Positives = 149/439 (33%), Gaps = 73/439 (16%) Query: 30 SLLSLPLVGSLPF-LPRHGHMHNNFFKLQKKYGPIYSVRM--GTKTTVIVGHHQLAKEVL 86 V + PF LP + ++ +L++ P+ VR+ G T +V A+ VL Sbjct: 7 GPTPADAVPAYPFSLPHALDLDPHYAELRRDE-PVSRVRLPYGEGTAWLVTRMSDARIVL 65 Query: 87 IKKGKDFSG-RPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKI 145 + + A RRL F +++ Sbjct: 66 GDSRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHTRLRRLVGKAFT--ARRVEEMRPR 123 Query: 146 ICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGI 205 + + +L D + H G D+ F+AV +++IC D +L + +++ + Sbjct: 124 VRSLVDSLLDDMVAH-GSPADLVE--FLAVPFPVAVICELLGVPLEDRDL--FRTFSDAM 178 Query: 206 IDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDT 265 + + T +++ + ++ ++ ++ ++L Sbjct: 179 LSST----------------RLTAAEIQRVQQDFMVYMDGLVAQRRDA----PTEDLLGA 218 Query: 266 LMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVK 325 L A N D+ L+ I+ + AG ET+ + + + LL Sbjct: 219 LALATDNDDH-----------LTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLT----- 262 Query: 326 KKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPML-IPHKANVDSSIGEF 384 R S L+ A + E+LR P+ A D + Sbjct: 263 -------------ERKRYESLVADPALVPAAVEEMLRYTPLVSAGSFVRVATEDVELSTV 309 Query: 385 AVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIG 444 V G +++ + + +E+ + D+ R NP ++ FG G CIG Sbjct: 310 TVRAGEPCVVHFASANRDEEVFDHADELDFHRERNP-----------HIAFGHGAHHCIG 358 Query: 445 EILARQELFLIMAWLLQRF 463 L R EL ++ L++RF Sbjct: 359 AQLGRLELQEALSALVRRF 377 >1CPT-A nrPDB Length = 428 Score = 155 bits (392), Expect = 4e-38, Method: Composition-based stats. Identities = 61/440 (13%), Positives = 142/440 (32%), Gaps = 67/440 (15%) Query: 56 LQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFA 115 + K+ + + G + + E+L + + R ++ + + Sbjct: 53 IATKHADVMQI--GKQPGLFSNAEGS--EILYDQNNEAFMR----SISGGCPHVIDSLTS 104 Query: 116 DSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAV 175 +R L + F +KLE+ I + L +G+ ++ Sbjct: 105 MDPPTHTAYRGLTLNWFQ--PASIRKLEENIRRIAQASVQRLLDFDGECDFMTDCALYYP 162 Query: 176 TNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSH 235 +V+ + + ++ + D P + ++ + Sbjct: 163 LHVV-MTALGVPEDDE----PLMLKLTQDFFGVHEPDEQAVAAP--RQSADEAARRFHET 215 Query: 236 VKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTT 295 + D N + RS +++ L +K+ D + D +I Sbjct: 216 IATFYDYFNG----FTVDRRSCPKDDVMSLLANSKL-----------DGNYIDDKYINAY 260 Query: 296 IGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEA 355 I AG +TT+S + L NP+ ++ L+ Sbjct: 261 YVAIATAGHDTTSSSSGGAIIGLSRNPEQLAL------------------AKSDPALIPR 302 Query: 356 TIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPE 415 + E +R + A D+ + + +G ++++ + + +E+ + PD+F Sbjct: 303 LVDEAVRWTAPVKSFM-RTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDIT 361 Query: 416 RFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFD-LEVPDDGQLP 474 RF N +L FG G C+G+ LA+ E+ + LL + +E+ +L Sbjct: 362 RFPN-----------RHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSGPPRLV 410 Query: 475 SLEGIPKVVFLIDSFKVKIK 494 + + + ++ Sbjct: 411 ATNFVGG----PKNVPIRFT 426 >6GK6-A nrPDB Length = 411 Score = 155 bits (391), Expect = 5e-38, Method: Composition-based stats. Identities = 66/388 (17%), Positives = 130/388 (33%), Gaps = 69/388 (17%) Query: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALF 135 + +L ++ +K D R D + + + AD H R A+ A Sbjct: 57 LKDPRLIRDF--RKLPDEVRRRYFPLSDRTTFMDQHMLDADPPDH---TRLRAIVQRAFS 111 Query: 136 KDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPEL 195 + L I + L D + + I+ F T VI+ + + Sbjct: 112 PRMMEGLRPRIQEIADGLIDAVIDRR-RMELIADFAFPLPTAVIAELL-----GLPVEDR 165 Query: 196 NVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFR 255 + + + ++ V E+ + V+ + + ++ R Sbjct: 166 GRFRRWTKILLAPAKDREFV--------------ERAQPVVEEFAAYFRALADARRKAPR 211 Query: 256 SDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTL 315 +++ L+ A+ LS + + + + AG ETT ++ + Sbjct: 212 ----DDLISGLLLAEEQEHK-----------LSPAELSSMVFLLLVAGHETTVHLIASGM 256 Query: 316 AFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKA 375 LL +P +++L E+ L+ + + E LR A + + Sbjct: 257 LLLLSHPAERRRLDEDP------------------GLVGSAVEEALRCEGPAELSTIRWS 298 Query: 376 NVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPF 435 D + V G V L A + + + + PD+F R N ++ F Sbjct: 299 LEDIELFGARVPAGEGVAAGLLAANRDPQHFPDPDRFDIGRSPN-----------RHIGF 347 Query: 436 GAGPRSCIGEILARQELFLIMAWLLQRF 463 G G C+G +LAR E + + LL+R Sbjct: 348 GGGIHFCLGAMLARIEAAIAFSTLLRRL 375 >1LG9-A nrPDB Length = 398 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 65/405 (16%), Positives = 124/405 (30%), Gaps = 81/405 (20%) Query: 77 GHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRK-------GIAFADSGAHWQLHRRLAM 129 H + ++V+ + FS R + D G RR Sbjct: 46 TAHAVVRQVMGDHQQ-FSTRRRWDPRDEIGGKGIFRPRELVGNLMDYDPPEHTRLRRKLT 104 Query: 130 ATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSID-ISFPVFVAVTNVISLICFNTSY 188 F L K Q++ I Q ++ D + G D I+F V+ + Sbjct: 105 PGFTLRKM--QRMAPYIEQIVNDRLDEMERA-GSPADLIAFVADKVPGAVLCELV-GVPR 160 Query: 189 KNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILE 248 + D + + + + + + D ++ L Sbjct: 161 DDRDMFMKLCHGHLDASLS-------------------------QKRRAALGDKFSRYLL 195 Query: 249 NYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTT 308 + R + M+ ++ + + +D + + AG + + Sbjct: 196 AMIARERKEPGEGMIGAVVA-------------EYGDDATDEELRGFCVQVMLAGDDNIS 242 Query: 309 SVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAP 368 ++ + +L +P+ ID G ++ + E++R V Sbjct: 243 GMIGLGVLAMLRHPEQ-------IDAFRGDEQSAQ-----------RAVDELIRYLTVPY 284 Query: 369 MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISP 428 P A D ++ + KG VI +L A + + D+ R P Sbjct: 285 SPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTREPIP-------- 336 Query: 429 SVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFD-LEVPDDGQ 472 ++ FG G C+G LAR EL + L +RF L + D Q Sbjct: 337 ---HVAFGHGVHHCLGAALARLELRTVFTELWRRFPALRLADPAQ 378 >4Z5Q-A nrPDB Length = 423 Score = 152 bits (385), Expect = 3e-37, Method: Composition-based stats. Identities = 72/439 (16%), Positives = 150/439 (34%), Gaps = 79/439 (17%) Query: 29 KSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRM-GTKTTVIVGHHQLAKEVLI 87 + ++ P GS + ++ KL + G V++ + +V + A+ VL Sbjct: 33 PAPVAYPFTGS-----EGLELSQSYAKLFED-GDPIRVQLPFGEPAWLVTRYDDARFVLT 86 Query: 88 KK--GKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKI 145 + + + + + + + I D H R + + A + Sbjct: 87 DRRFSRHLATQRDEPRMTPRAV-PESILTMDPPDH---TRLRTLVSKAFTPRRIESKRAW 142 Query: 146 ICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGI 205 I + + L + + + VI + D ++ + + Sbjct: 143 IGELAAGLVADMKAGGAPAELVGSYALAIPVTVICELL---GVPEDDR--TRLRGWCD-- 195 Query: 206 IDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDT 265 LS L D + V+ D L K E+ ++ R++ ++ Sbjct: 196 -AALSTGELTD----------------EECVQSFMD-LQKYFEDLVKERRAEPRDDLTSA 237 Query: 266 LMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVK 325 L++A+ + L++ ++ I G ETT S + + L ++ Sbjct: 238 LIEAR-----------DAHDRLAEPELIGLCISILIGGFETTASEISSFVHVLQQRRELW 286 Query: 326 KKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLI-PHKANVDSSIGEF 384 +L + + + A + E+LR P A I P A D ++G Sbjct: 287 TRLCADPEA------------------IPAAVEELLRFVPFAANGISPRYALEDMTVGGV 328 Query: 385 AVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIG 444 V +G VI++ A++ + + D+ + +R N ++ FG G C+G Sbjct: 329 LVREGEPVIVDTSAVNRDGLVFDNADEVVIDRADN-----------RHMVFGHGAHHCLG 377 Query: 445 EILARQELFLIMAWLLQRF 463 LAR EL + L++ Sbjct: 378 AHLARVELQEALKALVEGM 396 >5YSW-A nrPDB Length = 441 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 76/473 (16%), Positives = 145/473 (30%), Gaps = 99/473 (20%) Query: 18 PKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHN--NFFKLQKKYGPIYSVRMG-TKTTV 74 P + P F+ R H + ++ GP+ + Sbjct: 31 PSTESLRSPLPPE-----------FVRREDPFHVPPALVAVSER-GPVARATLAAGDPFW 78 Query: 75 IVGHHQLAKEVLIKKGKDFSGRPQMATLD-----------IASNNRKGIAFADSGAHWQL 123 +V ++ A+ VL S R Q R G Sbjct: 79 LVSGYEEARAVLSDPRFS-SDRFQYHPWFKELSPEFRERLRDDKARAGSFINMDPPEHTR 137 Query: 124 HRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLIC 183 +R+L F + + ++L I + ++ D + + ++ F A + +I + Sbjct: 138 YRKLLTGQFTVRR--IRELGARIDEIVAGRVDAMLAGGTTADLMTEFAFPAPSLMICELL 195 Query: 184 FNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLL 243 Y++ + L E +K+ D L Sbjct: 196 -GVRYED--------------------RAEFQQRASALLQMNAPVAEAVKNA-----DAL 229 Query: 244 NKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAG 303 ++ R++ +++ L+ L+D+ ++ + AG Sbjct: 230 RAFMQALVTDKRANPAGDIISGLIHHAGADP-----------ALTDDELINIANLLLIAG 278 Query: 304 VETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRL 363 +TT S++ + LL P L ++ + + E+LR Sbjct: 279 YDTTASMLGLGIFVLLQRPAQLATLRDDPSRIAD------------------AVEELLRY 320 Query: 364 RPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGT 423 V I A D + G+ V++++ A + + + W PD Sbjct: 321 LSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDPD------------L 368 Query: 424 QLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF---DLEVPDDGQL 473 L P +L FG G C+G+ LAR E+ A LL+R L VP + Sbjct: 369 DLTRPRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVPPEEVP 421 >2XKR-A nrPDB Length = 398 Score = 151 bits (382), Expect = 5e-37, Method: Composition-based stats. Identities = 59/247 (23%), Positives = 94/247 (38%), Gaps = 52/247 (21%) Query: 252 EKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVV 311 R+D +++ L+ +++ D E LSD+ ++ I G ETT + Sbjct: 191 AARRADPTDDLVSVLVSSEV-----------DGERLSDDELVMETLLILIGGDETTRHTL 239 Query: 312 KWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLI 371 LL N L + LL I E+LR + Sbjct: 240 SGGTEQLLRNRDQWDLLQRDP------------------SLLPGAIEEMLRWTAPVKNMC 281 Query: 372 PHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVS 431 D+ A+ G ++++ + + +E + +P++F +R N S Sbjct: 282 -RVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQRNPN-----------S 329 Query: 432 YLPFGAGPRSCIGEILARQELFLIMAWLLQRF-DLE-VPDDGQLP--------SLEGIPK 481 +L FG G C+G LAR EL L+ +L+R DL V DD LP LE +P Sbjct: 330 HLAFGFGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMP- 388 Query: 482 VVFLIDS 488 VVF Sbjct: 389 VVFTPSP 395 >1Q5D-A nrPDB Length = 419 Score = 151 bits (382), Expect = 5e-37, Method: Composition-based stats. Identities = 67/327 (20%), Positives = 121/327 (37%), Gaps = 62/327 (18%) Query: 189 KNGDPELNVIQNYNEGIIDNLSKDSLVDLVPW-----LKIFPNKTLEKLKSHVKIRNDLL 243 ++G E +V+++Y EGI + S + VP + F + T L + R D Sbjct: 137 RSGQEEFDVVRDYAEGI--PMRAISALLKVPAECDEKFRRFGSATARALGVGLVPRVDEE 194 Query: 244 NKILEN------------YKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNH 291 K L E+ R+ ++L L+QA + D LS Sbjct: 195 TKTLVASVTEGLALLHGVLDERRRNPLENDVLTMLLQA-----------EADGSRLSTKE 243 Query: 292 ILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLL 351 ++ +G I AG +TT ++ + + LL +P+ + + E Sbjct: 244 LVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAEP------------------G 285 Query: 352 LLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQ 411 L+ + EVLR + + A D ++ KG V + + + + + +PD Sbjct: 286 LMRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIPSALRDGTVFSRPDV 345 Query: 412 FMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDG 471 F R + + L +G GP C G LAR E + + + +RF + Sbjct: 346 FDVRR-----------DTSASLAYGRGPHVCPGVSLARLEAEIAVGTIFRRFPEMKLKET 394 Query: 472 QLPSLEGIPKVVFLIDSFKVKIKVRQA 498 + + I+S V +K +A Sbjct: 395 PVFGYHPAFR---NIESLNVILKPSKA 418 >5Z9I-A nrPDB Length = 398 Score = 151 bits (382), Expect = 6e-37, Method: Composition-based stats. Identities = 55/354 (15%), Positives = 108/354 (30%), Gaps = 56/354 (15%) Query: 124 HRRLA-MATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLI 182 HRRL + A K+E + I L D + D+ + ++ Sbjct: 83 HRRLRGLVDHAFTPSLVAKMESRVHGIIHELLDGVE--GKSQFDLVAEFAAPLPLIMISD 140 Query: 183 CFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDL 242 + + +G S +++ E+ Sbjct: 141 LLGVPESDRALFRQWMDKMLDGSEKFESPETV------------LEQEEELHKELELLWE 188 Query: 243 LNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGA 302 + + R +++ L+ A++ D + L+D+ I + Sbjct: 189 MRDYWHERAAESRKRPREDLISQLVHAEV-----------DGQKLNDSQISNIANRLLVN 237 Query: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLR 362 G TT ++ T+ L ++ R L+ A + E +R Sbjct: 238 GHLTTAMLIANTMLCLDAFSDQDARV------------------RADRSLVPALLEESMR 279 Query: 363 LRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAG 422 + N + + + K +++ A + +E+++ +PD F R N Sbjct: 280 YMSPI-CGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGRSPN--- 335 Query: 423 TQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSL 476 ++L FG G C+G LAR E + LL R D P+ Sbjct: 336 --------AHLGFGRGIHFCLGRQLARMESKAAVEILLDRLPTLRADPANPPTF 381 >2X9P-A nrPDB Length = 404 Score = 151 bits (380), Expect = 1e-36, Method: Composition-based stats. Identities = 74/425 (17%), Positives = 139/425 (32%), Gaps = 83/425 (19%) Query: 53 FFKLQKKYGPIYSVRM-GTKTTVIVGHHQLAKEVLIKK--GKDFSGRPQMATLDIASNNR 109 + + GPI+ VR +V H K++L + G+ P A + Sbjct: 31 LLRALQDRGPIHRVRTPAGDEAWLVTRHAELKQLLHDERIGRTHPDPPSAAQYVRSPFLD 90 Query: 110 KGIAFADSGAHWQLH---RRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSID 166 I+ AD+ + + H RRL F+ + +++ + + TL D G D Sbjct: 91 LLISDADAESGRRQHAETRRLLTPLFSARRVL--EMQPKVEEAADTLLDAFIA-QGPPGD 147 Query: 167 ISFPVFVA-VTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFP 225 + + V V+ + + Sbjct: 148 LHGELTVPFALTVLCEVI------------------------------------GVPPQR 171 Query: 226 NKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSE 285 L L + + +D D + + L++ K + + Sbjct: 172 RAELTTLLAGIAKLDD-------REGAVRAQDDLFGYVAGLVEHKRAEPGPDIISRLNDG 224 Query: 286 LLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTIS 345 L+++ + + AG+++ S++ + L +P + + D Sbjct: 225 ELTEDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAAALADPD------------ 272 Query: 346 DRNRLLLLEATIREVLRL-RPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEK 404 ++ + EVLR R +L P A+ D G + G V+ +L + +E+ Sbjct: 273 ------VMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDER 326 Query: 405 EWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFD 464 + P++F R NP +L FG G CIG LAR EL + L R Sbjct: 327 AFTGPEEFDAARTPNP-----------HLTFGHGIWHCIGAPLARLELRTMFTKLFTRLP 375 Query: 465 LEVPD 469 P+ Sbjct: 376 ELRPE 380 >2RFC-A nrPDB Length = 343 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 54/267 (20%), Positives = 99/267 (37%), Gaps = 44/267 (16%) Query: 202 NEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITN 261 N+ II + V+++ + P+ + K + I+ N +++ + Sbjct: 91 NKDIISEYAVRLPVNIISKILGIPDSDMPLFKLW-------SDYIIGNKRDENFNYVNNR 143 Query: 262 MLDTLMQAKMNSDNG----NAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAF 317 M+ L++ + +G AG + L+ + + I + G ETTT+++ + Sbjct: 144 MVSRLLEIFKSDSHGIINVLAGSSLKNRKLTMDEKIKYIMLLIIGGNETTTNLIGNMIRV 203 Query: 318 LLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANV 377 + NP + ID + + E LR L A Sbjct: 204 IDENPDI-------IDDALKNR--------------SGFVEETLRYYSPIQFLPHRFAAE 242 Query: 378 DSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGA 437 DS I + KG +VI+ L + + +E + +PD F R +L FG Sbjct: 243 DSYINNKKIKKGDQVIVYLGSANRDETFFDEPDLFKIGR------------REMHLAFGI 290 Query: 438 GPRSCIGEILARQELFLIMAWLLQRFD 464 G C+G LAR E + + +L F Sbjct: 291 GIHMCLGAPLARLEASIALNDILNHFK 317 >6HQG-A nrPDB Length = 425 Score = 150 bits (378), Expect = 2e-36, Method: Composition-based stats. Identities = 65/382 (17%), Positives = 133/382 (34%), Gaps = 59/382 (15%) Query: 90 GKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQE 149 + FS P + D A + + A + R+ A + LE II + Sbjct: 79 HEVFSSEPTIVLPDPADDFTLPMFIAMDPPKHDVQRKTVQPIVA--PNHLAYLEPIIRER 136 Query: 150 ISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNL 209 + D L G+ I+ V + +T + F+ + D + +++ Sbjct: 137 AGKILDDLPI--GEEINWVDKVSIELTTMTLATLFD--FPWEDR--RKLTFWSDVATSAP 190 Query: 210 SKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQA 269 L P + E L+ + + ++ + + E+ + +++ L Sbjct: 191 ESGILGTTDP-------EEHENLR--RQTLFECVDYFMRLWNERVNAPPKPDLISML--- 238 Query: 270 KMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLY 329 + ++ + L + + G +TT + + ++ L NP +KL Sbjct: 239 ---------AHGESTKNMDRMEYLGNLILLIVGGNDTTRNTISGSVLALHQNPDQDRKLR 289 Query: 330 EEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKG 389 E L+ A + E +R + + +A D +G + +G Sbjct: 290 E------------------NPGLIPAMVSETIRWQTPLA-YMRRRAKRDFELGGKTIREG 330 Query: 390 TEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILAR 449 +V + + + +E+ +P+ + ER +L FG G C+G LA Sbjct: 331 DKVAMWYVSGNRDEEVIDRPNDYWIER----------PRVRQHLSFGFGVHRCVGNRLAE 380 Query: 450 QELFLIMAWLLQRF-DLEVPDD 470 +L +I +L RF LEV Sbjct: 381 LQLKIIWEEILARFPRLEVVGP 402 >6F0B-A nrPDB Length = 395 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 66/398 (16%), Positives = 129/398 (32%), Gaps = 73/398 (18%) Query: 70 TKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFAD--SGAHWQLHRRL 127 + ++ + VL + + FS + + + A A HRRL Sbjct: 37 GTPAHVFSGYEDVRTVL--QDRRFSSDSRRPNFTELTPTLQSQAAAPPFVRTDNPDHRRL 94 Query: 128 AMATFALF-KDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNT 186 F + L I + + + D LA + V S F Sbjct: 95 RGTIAREFLPKHIELLRPAIREIVQGVLDGLAET----APPQDMLEAFAVPVASATVFRL 150 Query: 187 -SYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNK 245 D L + +G++ + + + E + + + Sbjct: 151 LGIPAEDRAL--LTRCVKGVVSAVGSED-------------EGAEVFR----TLGEYIGG 191 Query: 246 ILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVE 305 ++++ E I ++ Q K L+ + + I + G + Sbjct: 192 LVQDPSELPEDSLIRRLVTGPYQEK---------------QLTFHETIGVILMLIVGGYD 236 Query: 306 TTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRP 365 TT S + +L P+ ++E ++ + + E+LR Sbjct: 237 TTASTISLSLVSYALQPEKFSVVHEHPER------------------IPLLVEELLRYHT 278 Query: 366 VAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQL 425 V+ + + A D +G V G V+ L + +E + PD+ +R Sbjct: 279 VSQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR--------- 329 Query: 426 ISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 PSV ++ FG GP C+G+ LAR EL + +++R Sbjct: 330 --PSVPHVGFGYGPHQCVGQALARVELQEAIPAVIRRL 365 >6M7L-A nrPDB Length = 404 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 70/406 (17%), Positives = 114/406 (28%), Gaps = 83/406 (20%) Query: 61 GPIYSVRM--GTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSG 118 GP+ + + G+ + + +EVL + F R + G Sbjct: 48 GPLVRIPLEDGSAVHWFALGYDVVREVL--GSEKFDKRVIGTHFNHQEMALPGNLLQLDP 105 Query: 119 AHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNV 178 RR+ +++ + Q LE + + D +A+ + V Sbjct: 106 PEHTRLRRMVAPAYSVRRM--QALEPRVQAIVDDHLDTMASTGPPVEFLREVAGPMAARV 163 Query: 179 ISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKI 238 D + + G K L H + Sbjct: 164 ACEFL---GIPLDDRGELIRLTAHRG---------------------GKRRRVLNGHAYL 199 Query: 239 RNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGD 298 + + R D ML + +SD + Sbjct: 200 A------YMRELAARLRRDPGDGMLGMV-------------ARDHGADISDEELAGLCAV 240 Query: 299 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIR 358 + + VE T S + LL +P+ L E R L E + Sbjct: 241 VMNSSVEQTESCLAAGTLLLLEHPEQFALLRE------------------RPELGEQAVE 282 Query: 359 EVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHH-NEKEWHQPDQFMPERF 417 E++R V L P A D IG + KG V +L A + + D F R Sbjct: 283 EIVRYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAANRADPAL----DGFDITR- 337 Query: 418 LNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 ++ FG G C+G LAR EL + L+ RF Sbjct: 338 ----------KESRHVAFGHGIHHCLGAPLARMELRIAFTTLVSRF 373 >6FSH-A nrPDB Length = 398 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 59/424 (13%), Positives = 128/424 (30%), Gaps = 83/424 (19%) Query: 61 GPIYSVRMGT----KTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRK------ 110 G + + +G+ +TT + H + ++VL + FS R + D Sbjct: 26 GTLTKISIGSGADAETTWLAAGHAVVRQVLGDHQQ-FSTRRRWDPRDEIGGKGIFRPREL 84 Query: 111 -GIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISF 169 G R L F + ++L I + ++ D + G D+ Sbjct: 85 VGNLMDYDPPEHTRLRHLLTPGFTQRRM--RRLAPRIEEIVTDRLDAME-QAGPPADLIE 141 Query: 170 PVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTL 229 V + + D + + + + + Sbjct: 142 LFADEVPGAVLCELIGVPRDDRDMFMKLCHGHLDASLS---------------------- 179 Query: 230 EKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSD 289 + D ++ L + R D + +++ + + ++D Sbjct: 180 ---QKRRAALGDKFSRYLLAMIARERKDPGDGFIGSIVA-------------EHGDTITD 223 Query: 290 NHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNR 349 + + AG + + ++ + LL +P+ L + Sbjct: 224 EELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQSA-------------- 269 Query: 350 LLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQP 409 + + E++R V P A D + + + +G V+ +L + + Sbjct: 270 ----DRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDA 325 Query: 410 DQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFD-LEVP 468 D+ R P ++ FG G C+G L R +L + L +RF L++ Sbjct: 326 DRLDVTRTPVP-----------HVAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLA 374 Query: 469 DDGQ 472 D Q Sbjct: 375 DPAQ 378 >5L1U-A nrPDB Length = 401 Score = 149 bits (375), Expect = 3e-36, Method: Composition-based stats. Identities = 84/427 (19%), Positives = 141/427 (33%), Gaps = 85/427 (19%) Query: 58 KKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFA-- 115 +K GPI V + +V + + +L + S P ++ +A A Sbjct: 28 QKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSN-PNPQPSAKSAARAFMVALAAG 86 Query: 116 ----DSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDI-SFP 170 A R L + + ++ I + L D LA +D+ Sbjct: 87 DDHETEPARHAQMRSLLIP--RFSTRRLRLMKTRIEHHVDELLDQLAASAP-PVDLHRVL 143 Query: 171 VFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLE 230 F T V+ + D E + G D + + Sbjct: 144 SFRLPTMVVCDLL---GVPLADRER--FGQWARGTFDQSDNEHSANTF------------ 186 Query: 231 KLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDN 290 +++ +LE + R + ++L L+ K LSD Sbjct: 187 ---------QQVVDYMLELV-ARKRVEPGDDILSELIAEK-------------DGALSDA 223 Query: 291 HILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRL 350 I + G ETT + LL NP + +L E+ Sbjct: 224 DIAHLGNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAEDP------------------ 265 Query: 351 LLLEATIREVLRLR---PVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWH 407 L A + E+LRL + LIP A+ D ++GE + G V++ + A +++++ + Sbjct: 266 GLAPAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFP 325 Query: 408 QPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR---FD 464 F R S+L FG G R CIG LAR EL + L +R Sbjct: 326 DGGLFDLTR----------VRPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLR 375 Query: 465 LEVPDDG 471 L VP++ Sbjct: 376 LAVPEES 382 >6FYJ-A nrPDB Length = 421 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 75/444 (16%), Positives = 154/444 (34%), Gaps = 73/444 (16%) Query: 62 PIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS--NNRKGIAFADSGA 119 I+ R+ K + +G + A E+ + F R A + + G+ D Sbjct: 39 DIFETRLLGKKAICMGGKEAA-EIFYDT-EKFK-RKDAAPNRVVQTLFGKNGVQALDGQT 95 Query: 120 HWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVI 179 H HR+ + + D +KL I ++ D + ++ ++ Sbjct: 96 H--KHRKEMFMSI-MSPDELEKLTDITKKQWEIAVDKWEQMD------KVILYEEAKEIM 146 Query: 180 SLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIR 239 + + N ++ + + + V L WL +++ +I Sbjct: 147 CRTA--CQWAGVPVQENEVKRLTKNLGAMFESAAAVGLKHWL-------GRHARNYEEI- 196 Query: 240 NDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDI 299 + ++++ ++ + L + D + LL + +I Sbjct: 197 --WIEELIDRVRDGKVNPPENTTLHKF----------SWYRDLEGNLLDTETAAVEVINI 244 Query: 300 F---GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEAT 356 A + + L H P+ K+KL + Sbjct: 245 LRPIVA----IAIFINFIALALHHYPEEKEKLKS-----------------GDKKYSQMF 283 Query: 357 IREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPER 416 ++EV R P P ++ D + + ++GT +++L+ +H+ + W PD F P+R Sbjct: 284 VQEVRRFYPFFPFVVA-LVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDR 342 Query: 417 FLNPAGTQLISPSVSYLPFGAGP----RSCIGEILARQELFLIMAWLLQRFDLEVPDDG- 471 F G+ S++P G G C GE + + + + + +L R D EVPD Sbjct: 343 FAKWEGSP-----FSFIPQGGGDYFMGHRCAGEWVTIEVMKVSLDYLTNRMDYEVPDQDL 397 Query: 472 --QLPSLEGIPKVVFLIDSFKVKI 493 + S+ IP +I + K +I Sbjct: 398 SFSMASMPSIPHSKVVIKNVKKRI 421 >4TX3-A nrPDB Length = 404 Score = 144 bits (364), Expect = 6e-35, Method: Composition-based stats. Identities = 51/402 (12%), Positives = 115/402 (28%), Gaps = 77/402 (19%) Query: 78 HHQLAKEVLIKKGK-----DFSGRPQMATLDIASNNRKGIAFADS-GAHWQLHRRLAMAT 131 H + ++VL + F R ++ + D R L Sbjct: 53 GHAVVRQVLGDHKRFSTRRRFDRRDEIGGTGVFRPRELVGNLMDYDPPEHTRLRHLLTPG 112 Query: 132 FALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNG 191 F + ++L I + ++ D + G D+ V + + Sbjct: 113 FTQRRM--RRLAPRIEEIVTDRLDAME-QAGPPADLIELFADEVPGAVLCELIGVPRDDQ 169 Query: 192 DPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYK 251 L + + + + + ++ Sbjct: 170 AMFLQLCHRHLDASLSA------------------------RKRAAAGEAFARYLVA-MM 204 Query: 252 EKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVV 311 + R D + +++ + + ++D + + AG + + ++ Sbjct: 205 ARERKDPGDGFIGSIVA-------------EHGDTITDEELRGVCVQLMLAGDDNVSGMI 251 Query: 312 KWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLI 371 + LL +P+ L + + + E++R V Sbjct: 252 GLGVLALLRHPEQIAALRGDDQSA------------------DRAVDELIRYLTVPYAPT 293 Query: 372 PHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVS 431 P A D + + + +G V+ +L + + D+ R P Sbjct: 294 PRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTRTPVP----------- 342 Query: 432 YLPFGAGPRSCIGEILARQELFLIMAWLLQRFD-LEVPDDGQ 472 ++ FG G C+G L R +L + L +RF L++ D Q Sbjct: 343 HVAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQ 384 >2WM5-A nrPDB Length = 435 Score = 144 bits (364), Expect = 7e-35, Method: Composition-based stats. Identities = 43/250 (17%), Positives = 86/250 (34%), Gaps = 41/250 (16%) Query: 224 FPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQD 283 F + L + + E R + ++ +L++A++ D Sbjct: 207 FGDPDLATDFDEFMQVSADIGAYATALAEDRRVNHHDDLTSSLVEAEV-----------D 255 Query: 284 SELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPT 343 E LS I + + AG ETT + + + L P+ + + + + D Sbjct: 256 GERLSSREIASFFILLVVAGNETTRNAITHGVLALSRYPEQRDRWWSDFD---------- 305 Query: 344 ISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNE 403 L + E++R + + D + + G +V + + + +E Sbjct: 306 -------GLAPTAVEEIVRWASPV-VYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDE 357 Query: 404 KEWHQPDQFMPERFLNPAGTQLISPSVSYLPF-GAGPRSCIGEILARQELFLIMAWLLQR 462 ++ P F R NP +L F G G C+G LAR+E+ + L ++ Sbjct: 358 SKFADPWTFDLARNPNP-----------HLGFGGGGAHFCLGANLARREIRVAFDELRRQ 406 Query: 463 FDLEVPDDGQ 472 V + Sbjct: 407 MPDVVATEEP 416 >3RWL-A nrPDB Length = 426 Score = 144 bits (363), Expect = 9e-35, Method: Composition-based stats. Identities = 66/445 (14%), Positives = 144/445 (32%), Gaps = 95/445 (21%) Query: 39 SLPFLPRHGHMHNNFFKLQKK----------YGPIYSVRMGTKTTVIVGHHQLAKEVLIK 88 S+P L + + F +L+K +GP +S+ + + + Sbjct: 30 SIPELFYNDSVGEYFKRLRKDDPVHYCADSAFGPYWSI------------TKYNDIMHVD 77 Query: 89 KGKDF----SGRPQMATLDIASNNRKGIAFADS-----GAHWQLHRRLAMATFALFKDGD 139 D +G + D G + R+ A Sbjct: 78 TNHDIFSSDAGYGGIIIDDGIQKGGDGGLDLPNFIAMDRPRHDEQRKAVSPIVAPANLA- 136 Query: 140 QKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQ 199 LE I + +S D L G+ D V + +T + F+ + E + Sbjct: 137 -ALEGTIRERVSKTLDGLPV--GEEFDWVDRVSIEITTQMLATLFDFPF----EERRKLT 189 Query: 200 NYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSI 259 +++ + ++ ++ K+ + + + E+ D Sbjct: 190 RWSDVTTAAPGGGVV------------ESWDQRKTELLECAAYFQVL---WNERVNKDPG 234 Query: 260 TNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLL 319 +++ L + ++ L + + G +TT + + + L Sbjct: 235 NDLISML------------AHSPATRNMTPEEYLGNVLLLIVGGNDTTRNSMTGGVLALH 282 Query: 320 HNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDS 379 NP KL + L+E + E++R + + A DS Sbjct: 283 KNPDQFAKL------------------KANPALVETMVPEIIRWQTPLAH-MRRTAIADS 323 Query: 380 SIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGP 439 +G + KG +V++ ++ + +++ +P++F+ +R +L FG G Sbjct: 324 ELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDR----------PRPRQHLSFGFGI 373 Query: 440 RSCIGEILARQELFLIMAWLLQRFD 464 C+G LA +L ++ +L RF Sbjct: 374 HRCVGNRLAEMQLRILWEEILTRFS 398 >1UE8-A nrPDB Length = 367 Score = 142 bits (358), Expect = 4e-34, Method: Composition-based stats. Identities = 53/314 (16%), Positives = 107/314 (34%), Gaps = 47/314 (14%) Query: 153 LCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKD 212 L D L + + S V V + D E +VI+++ + + Sbjct: 75 LHDELRNLTADAFNPSNLPVDFVREVTVKLL-----SELDEEFDVIESFAIPLPILVISK 129 Query: 213 SLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMN 272 L N ++K+K + L + E + + + + + ++ Sbjct: 130 MLGI---------NPDVKKVKDWSDLVALRLGRADEIFSIGRKYLELISFSKKELDSRKG 180 Query: 273 SDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEI 332 + + + LS+ + AG ETTT+++ + + E+ Sbjct: 181 KEIVDLTGKIANSNLSELEKEGYFILLMIAGNETTTNLIGNAIEDFTLY-NSWDYVREKG 239 Query: 333 DQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEV 392 + E LR P M I + +D+G V Sbjct: 240 ALK--------------------AVEEALRFSPPV-MRTIRVTKEKVKIRDQVIDEGELV 278 Query: 393 IINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQEL 452 + + + + +E+ + PD F+P+R NP +L FG+G C+G LAR E Sbjct: 279 RVWIASANRDEEVFKDPDSFIPDRTPNP-----------HLSFGSGIHLCLGAPLARLEA 327 Query: 453 FLIMAWLLQRFDLE 466 + + ++F ++ Sbjct: 328 RIALEEFAKKFRVK 341 >5FYF-A nrPDB Length = 470 Score = 142 bits (358), Expect = 4e-34, Method: Composition-based stats. Identities = 77/476 (16%), Positives = 161/476 (33%), Gaps = 90/476 (18%) Query: 12 LAYLFWPKRRCPGAKYP-KSLLSLPLVG-----------SLPFLPRHGHMHNNFFKLQ-- 57 L +L KR+ G + P + P+ S PFL R G F +L+ Sbjct: 32 LKFLMSAKRKTFGPRRPMPEFVETPIPDVNTLALEDIDVSNPFLYRQGQWRAYFKRLRDE 91 Query: 58 -----KK---YGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKD-FSGRPQMATLDIASNN 108 +K +GP +S V + + + K D FS PQ+ D Sbjct: 92 APVHYQKNSPFGPFWS----------VTRFEDI--LFVDKSHDLFSAEPQIILGDPPEGL 139 Query: 109 RKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDIS 168 + A + R + + +++E +I + D L T + + Sbjct: 140 SVEMFIAMDPPKHDVQR--SSVQGVVAPKNLKEMEGLIRSRTGDVLDSLPTD--KPFNWV 195 Query: 169 FPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKT 228 V +T + + Y+ + + + + + + Sbjct: 196 PAVSKELTGRMLATLLDFPYEERHKLVEWSDRMAGAASATGGEFADENAMF------DDA 249 Query: 229 LEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLS 288 + +S ++ D + + + +++ L K D N Sbjct: 250 ADMARSFSRLWRD------KEARRAAGEEPGFDLISLLQSNKETKDLINR---------- 293 Query: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRN 348 + + + G +TT + + L + P+ +KL + Sbjct: 294 PMEFIGNLTLLIVGGNDTTRNSMSGGLVAMNEFPREFEKL------------------KA 335 Query: 349 RLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQ 408 + L+ + E++R + + A D +G + KG V++ + + +E+++ Sbjct: 336 KPELIPNMVSEIIRWQTPLA-YMRRIAKQDVELGGQTIKKGDRVVMWYASGNRDERKFDN 394 Query: 409 PDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFD 464 PDQF+ +R + +++ FG G C+G LA +L ++ +L+RFD Sbjct: 395 PDQFIIDR----------KDARNHMSFGYGVHRCMGNRLAELQLRILWEEILKRFD 440 >3MGX-A nrPDB Length = 415 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 44/202 (21%), Positives = 74/202 (36%), Gaps = 31/202 (15%) Query: 262 MLDTLMQAKMNSDNGN-AGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLH 320 D L+ A+ + + L+ + +L ++ G ETT + + L Sbjct: 213 YFDELITARRKEPGDDLVSTLVTDDDLTIDDVLLNCDNVLIGGNETTRHAITGAVHALAT 272 Query: 321 NPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSS 380 P + L + + + EVLR A M + D + Sbjct: 273 VPGLLTALRDGSADV------------------DTVVEEVLRWTSPA-MHVLRVTTADVT 313 Query: 381 IGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPR 440 I + GT V+ L A + + E+ PD F+P R N ++ FG G Sbjct: 314 INGRDLPSGTPVVAWLPAANRDPAEFDDPDTFLPGRKPN-----------RHITFGHGMH 362 Query: 441 SCIGEILARQELFLIMAWLLQR 462 C+G LAR EL +++ L +R Sbjct: 363 HCLGSALARIELSVVLRVLAER 384 >6HQW-A nrPDB Length = 445 Score = 141 bits (356), Expect = 5e-34, Method: Composition-based stats. Identities = 42/323 (13%), Positives = 105/323 (32%), Gaps = 38/323 (11%) Query: 160 HNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVP 219 + +++ + +V+ + + + D + I+ L Sbjct: 149 TPAKMVEMEAEIRRRTASVLDSLPWGERFDWVDKVSIELTTGMLAILFGFPWADRRLLTF 208 Query: 220 WLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAG 279 W + L + R L ++ ++ + + L+ ++S+ N Sbjct: 209 WSDWAGDVELTLARELADTRFGFLGEMAHYFQRLWGARMQAPPSGDLISMMIHSEAMN-- 266 Query: 280 PDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFS 339 +S + + + G +TT + + + L P ++ L Sbjct: 267 ------HMSPQEFMGNLVLLIVGGNDTTRNTMSGIVHALDKFPDQRELL----------- 309 Query: 340 RTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWAL 399 L+ ++E +R + A D+ + + G +VI+ + Sbjct: 310 -------ERDASLIPNAVQECIRYVTPLAH-MRRTATADTELFGNQIKAGEKVILWYISA 361 Query: 400 HHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWL 459 + +E + PD+ M +R + +L FG G C+G LA +L +++ + Sbjct: 362 NRDETVFENPDKLMVDR----------PNARRHLSFGHGIHRCVGARLAELQLRILLEEM 411 Query: 460 L-QRFDLEVPDDGQLPSLEGIPK 481 +R + V + + + Sbjct: 412 HERRMRVRVAGEVERVRANFVHG 434 >6CVC-A nrPDB Length = 433 Score = 141 bits (354), Expect = 8e-34, Method: Composition-based stats. Identities = 72/464 (15%), Positives = 146/464 (31%), Gaps = 76/464 (16%) Query: 21 RCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIY---SVRMGTKTT---- 73 R G P+ L+ +GSL F R + F ++ PI + + T Sbjct: 14 RVNGTPPPEVPLADIELGSLEFWGRDDDFRDGAFATLRREAPISFWPPIELAGLTAGKGH 73 Query: 74 VIVGHHQLAKEVLIKKGKDFSGRPQMAT--LDIASNNRKGIAFADSGAHWQLHRRLAMAT 131 + H + + F P + G Q R + Sbjct: 74 WALTKHDDIHFA-SRHPEIFHSSPNIVIHDQTPELAEYFGSMIVLDDPRHQRLRSIVSRA 132 Query: 132 FALFKDGDQKLEKIICQEISTLCDMLATH--NGQSIDISFPVFVAVTNVISLICFNTSYK 189 F ++E + + L + + +GQ+ +S +I + + Sbjct: 133 FT--PKVVARIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMM--GIPE 188 Query: 190 NGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILEN 249 ++ N G D D D +L++ + + Sbjct: 189 EDHEQIFHWTNVILGFGDP---DLTTDFDEFLQV----------------SMAIGGYATA 229 Query: 250 YKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTS 309 + R + ++ +L++A++ D E LS + I + AG ETT + Sbjct: 230 LADDRRVNHHGDLTTSLVEAEV-----------DGERLSSSEIAMFFILLVVAGNETTRN 278 Query: 310 VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPM 369 + + L P + K + + D L + E++R + Sbjct: 279 AISHGMLALSRYPDERAKWWSDFD-----------------GLAATAVEEIVRWASPV-V 320 Query: 370 LIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPS 429 + + D + + G +V + + + +E+++ P F R NP Sbjct: 321 YMRRTLSQDVDLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQ-------- 372 Query: 430 VSYLPF-GAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQ 472 + F G G C+G LAR+E+ ++ L ++ V + Sbjct: 373 ---VGFGGGGAHFCLGANLARREIRVVFDELRRQMPDVVATEEP 413 >3A1L-A nrPDB Length = 425 Score = 141 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 42/266 (15%), Positives = 93/266 (34%), Gaps = 39/266 (14%) Query: 205 IIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLD 264 +++ + + ++ L P + L+++ + + + R+++ + Sbjct: 148 LVEGFAAPLPILVISALLGIPEEDHTWLRANAVALQEASTTRARDGRGYARAEAASQEFT 207 Query: 265 TLMQAKMNSDNGNA---------GPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTL 315 + +++ G+ LS + I+ T + AG ETTT+ + + Sbjct: 208 RYFRREVDRRGGDDRDDLLTLLVRARDTGSPLSVDGIVGTCVHLLTAGHETTTNFLAKAV 267 Query: 316 AFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKA 375 L + V +L + A + E++R P + A Sbjct: 268 LTLRAHRDVLDELRTTPES------------------TPAAVEELMRYDPPV-QAVTRWA 308 Query: 376 NVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPF 435 D +G+ + +G+ V+ L + + + + PD R + + F Sbjct: 309 YEDIRLGDHDIPRGSRVVALLGSANRDPARFPDPDVLDVHR-----------AAERQVGF 357 Query: 436 GAGPRSCIGEILARQELFLIMAWLLQ 461 G G C+G LAR E + + LL Sbjct: 358 GLGIHYCLGATLARAEAEIGLRALLD 383 >3TKT-A nrPDB Length = 450 Score = 139 bits (351), Expect = 2e-33, Method: Composition-based stats. Identities = 59/309 (19%), Positives = 112/309 (36%), Gaps = 52/309 (16%) Query: 183 CFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDL 242 ++ L + Q G ++++K L DL P E++ V Sbjct: 191 ILGVPPEDEPKMLFLTQQMFGGQDEDMNKSGLKDLPP----------EQISQIVAGAVAE 240 Query: 243 LNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGA 302 + + R + ++ + A + D E +SD A Sbjct: 241 FERYFAGLAAERRRNPTDDVATVIANAVV-----------DGEPMSDRDTAGYYIITASA 289 Query: 303 GVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLR 362 G +TT++ L +P + ++ +DRN LL + E +R Sbjct: 290 GHDTTSASSAGAALALARDPDLFARVK---------------ADRN---LLPGIVEEAIR 331 Query: 363 LRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAG 422 + A D+ + + G +++N A +H+ ++ +P +F P R Sbjct: 332 WTTPVQHFM-RTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTR------ 384 Query: 423 TQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFD-LEVPDDGQLPSLEGIPK 481 P+ +L FGAG C+G LAR E+ +++ LL R D LE+ + + + + Sbjct: 385 -----PANRHLAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRVNSTFVGG 439 Query: 482 VVFLIDSFK 490 L +K Sbjct: 440 FKSLPMRWK 448 >5DQN-A nrPDB Length = 426 Score = 138 bits (348), Expect = 4e-33, Method: Composition-based stats. Identities = 44/225 (19%), Positives = 75/225 (33%), Gaps = 44/225 (19%) Query: 249 NYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTT 308 E+ + +++ L++A D D E LSD+ + + AG ETT Sbjct: 209 KMAEERAVNPTEDIVTKLIEA-----------DIDGEKLSDDEFGFFVVMLAVAGNETTR 257 Query: 309 SVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAP 368 + + + NP + +E E E++R Sbjct: 258 NSITHGMIAFAQNPDQWELYKKERP--------------------ETAADEIVRWATPVS 297 Query: 369 MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISP 428 A D +G + KG V+++ + + +E+ + P F R NP Sbjct: 298 AFQ-RTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNILRSPNP-------- 348 Query: 429 SVSYLPFGA-GPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQ 472 ++ FG G CIG LAR + LI + P Sbjct: 349 ---HVGFGGTGAHYCIGANLARMTINLIFNAIADNMPDLKPIGAP 390 >6DCD-A nrPDB Length = 424 Score = 133 bits (334), Expect = 2e-31, Method: Composition-based stats. Identities = 43/223 (19%), Positives = 77/223 (34%), Gaps = 39/223 (17%) Query: 241 DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF 300 L+ Y E R ++L L A + D ++ + +F Sbjct: 201 QWLDDKFSAYIEDRRRQPRNDVLTALATATYPDGSTPEVID----------VVRSATFLF 250 Query: 301 GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV 360 AG ETT ++ + L P ++++L E L+ I E Sbjct: 251 AAGQETTAKLLTAAMRVLGDRPDIQRRLRE------------------NRSLIPNFIEES 292 Query: 361 LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420 LR+ A +++G + GT V++ A + + + + P +F +R Sbjct: 293 LRMDSPVKS-DSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDR---- 347 Query: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 ++ F G SC G LAR E + + +L R Sbjct: 348 ------PNVREHMAFARGVHSCPGGPLARVEGRVSLERILDRM 384 >5HDI-A nrPDB Length = 404 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 47/293 (16%), Positives = 103/293 (35%), Gaps = 41/293 (13%) Query: 181 LICFNTSYKNGDPELNVIQNYNEG---IIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVK 237 I + + + +G + ++ + +V L P+ + +L Sbjct: 113 RIRVMEQFTVQAADRLWVDGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGY 172 Query: 238 IRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSEL--------LSD 289 LL ++EN + ++ L + + + + + EL L Sbjct: 173 AATQLLEGLVENDQLVAAGVALME-LSGYIFEQFDRAAADPRDNLLGELATACASGELDT 231 Query: 290 NHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNR 349 + +F AG E+T +++ + L P +++++ + Sbjct: 232 LTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQVRANPE---------------- 275 Query: 350 LLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQP 409 LL A I E LR P H N +++ + + +++ A + + ++ P Sbjct: 276 --LLGAFIEETLRYEPPFRGHYRHVRNA-TTLDGTELPADSHLLLLWGAANRDPAQFEAP 332 Query: 410 DQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 +F +R + ++ FG G C+G LAR E +++ LL R Sbjct: 333 GEFRLDR----------AGGKGHISFGKGAHFCVGAALARLEARIVLRLLLDR 375 >2ZQJ-A nrPDB Length = 417 Score = 132 bits (331), Expect = 4e-31, Method: Composition-based stats. Identities = 70/470 (14%), Positives = 154/470 (32%), Gaps = 76/470 (16%) Query: 42 FLPRHGHMHNNFFKLQKKY-----------GPIYSVRMGTKTTVIVGHHQLAKEVLIKKG 90 +P + N+ L++ Y ++ R+ K + + + AK V Sbjct: 4 QIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGKNFICMTGAEAAK-VFYDTD 62 Query: 91 KDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEI 150 + + + I D AH HR++ + + ++L +++ +E Sbjct: 63 RFQRQNALPKRVQKSLFGVNAIQGMDGSAHI--HRKMLFLSL-MTPPHQKRLAELMTEEW 119 Query: 151 STLCDMLATHNGQSIDISFPVFVAVTNVISLI-CFNTSYKNGDPELNVIQNYNEGIIDNL 209 + +F ++ + C+ + E ++ + ID + Sbjct: 120 KAAVTRWEKAD------EVVLFEEAKEILCRVACYWAGVPLKETE---VKERADDFIDMV 170 Query: 210 SKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQA 269 V K + + + ++E+ + + L + Sbjct: 171 DAFGAV----------GPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMAFH 220 Query: 270 KMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLY 329 + Q ++ ++ + I + + ++ L +P+ K+ L Sbjct: 221 TQEDGS------QLDSRMAAIELINVLRPIVA-----ISYFLVFSALALHEHPKYKEWLR 269 Query: 330 EEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKG 389 G SR E ++EV R P P L D KG Sbjct: 270 S------GNSRER-----------EMFVQEVRRYYPFGPFLGA-LVKKDFVWNNCEFKKG 311 Query: 390 TEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGP----RSCIGE 445 T V+++L+ +H+ + W PD+F PERF +P G G C GE Sbjct: 312 TSVLLDLYGTNHDPRLWDHPDEFRPERFAEREENLFD-----MIPQGGGHAEKGHRCPGE 366 Query: 446 ILARQELFLIMAWLLQRFDLEVPDDG---QLPSLEGIPKVVFLIDSFKVK 492 + + + + +L+ + + +VP+ L + +P+ F++ + K Sbjct: 367 GITIEVMKASLDFLVHQIEYDVPEQSLHYSLARMPSLPESGFVMSGIRRK 416 >2FR7-A nrPDB Length = 412 Score = 132 bits (331), Expect = 4e-31, Method: Composition-based stats. Identities = 34/205 (16%), Positives = 75/205 (36%), Gaps = 37/205 (18%) Query: 283 DSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTP 342 D+ ++ + + AG++TT + + + L P +L + Sbjct: 232 DTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRADP---------- 281 Query: 343 TISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHN 402 L E +R D + + +G +V++ L + + + Sbjct: 282 --------SLARNAFEEAVRFESPVQTF-FRTTTRDVELAGATIGEGEKVLMFLGSANRD 332 Query: 403 EKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 + W PD++ R + ++ FG+G C+G+++AR E +++A L ++ Sbjct: 333 PRRWDDPDRYDITR-----------KTSGHVGFGSGVHMCVGQLVARLEGEVVLAALARK 381 Query: 463 F-------DLEVPDDGQLPSLEGIP 480 L+ + L LE +P Sbjct: 382 VAAIEIAGPLKRRFNNTLRGLESLP 406 >5HIW-A nrPDB Length = 398 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 68/409 (16%), Positives = 133/409 (32%), Gaps = 73/409 (17%) Query: 74 VIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFA 133 V++ + +++ + FS R T D + G RRL Sbjct: 41 VVLRGADVV--AVLRDSETFSTR----TYDTGIMKGALVTLG--GEAHTRMRRL-FNAVL 91 Query: 134 LFKDGDQKLEKIICQEISTLCDML-ATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGD 192 + + E + + + L + D +++ ++ F Sbjct: 92 SPRVISRYEEATVTPVARRVVERLVRKERAELFD---DFAISMPMGVTSALFGL------ 142 Query: 193 PELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKE 252 PE + + N+ +I + + ++ P + + L E Sbjct: 143 PEERIAE--NDALIRKMIRSVVMPQDPVVVAEGRSAH-----------AAMEAQLREIAE 189 Query: 253 KFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVK 312 + + +L + +A + G + + + ETT+ ++ Sbjct: 190 REVAHPSDTLLGEIARAIVAEGLGGVEACE-----------GVVLTLILGSYETTSWMLA 238 Query: 313 WTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIP 372 L LL +P +L ++ LL I E R A I Sbjct: 239 NLLVALLAHPDAMNQLRQQP------------------SLLPQAIEESTRWCSSAA-GIV 279 Query: 373 HKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSY 432 +++IG + GT + ++L A H++E+ + +P+ F R V Sbjct: 280 RFVEREATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDIHRRP-----------VGM 328 Query: 433 LPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPK 481 L FG G C+G LAR E + ++ LL+RF D P+ P+ Sbjct: 329 LNFGGGLHYCVGAPLARMEARVGVSLLLERFPALRADPTVQPTFSTAPR 377 >5LIV-A nrPDB Length = 450 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 59/303 (19%), Positives = 111/303 (36%), Gaps = 49/303 (16%) Query: 194 ELNVIQNYNEGIIDNLSKDSLVDLVP-WLKIFPNK--------TLEKLKSHVKIRNDLLN 244 E ++ +E ++D L+ VDL+ + P + EKL + +L Sbjct: 151 EERFVRPISEQVVDRLAGKPRVDLLEDFAMELPRRVIGELFGFPAEKLHETDERVRAMLR 210 Query: 245 KILENYKEKFRSDSITNMLDTL--MQAKMNSDNGNAGPDQDSELL---------SDNHIL 293 ++ + ++S +TL + + ++ + E+L + Sbjct: 211 GLVRMHDPAAVAESQRAYGETLGLITEVVERESRDTSDTLLGEILRTLKAEHMDTIEASR 270 Query: 294 TTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLL 353 + + G ETT+ +V T+ LL +P ++ ++ LL Sbjct: 271 QIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQDP------------------SLL 312 Query: 354 EATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFM 413 A I E +R P + + D + + A+ GT V + A +++E + P+ + Sbjct: 313 PAAIEEGMRWCP-SSFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYD 371 Query: 414 PERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQL 473 +R PA FG G C+G LAR E + + LL RF + Sbjct: 372 IDRKPLPAANV----------FGGGAHFCVGAPLARMEARVGLQALLARFPGLRAVPEER 421 Query: 474 PSL 476 PS Sbjct: 422 PSF 424 >3IVY-A nrPDB Length = 433 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 43/216 (19%), Positives = 75/216 (34%), Gaps = 44/216 (20%) Query: 249 NYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTT 308 E+ + +++ L+QA D D E LSD+ + + AG ETT Sbjct: 226 KMAEEKAKNPADDIVTQLIQA-----------DIDGEKLSDDEFGFFVVMLAVAGNETTR 274 Query: 309 SVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAP 368 + + + +P + LY+++ E E++R Sbjct: 275 NSITQGMMAFAEHPDQWE-LYKKVRP-------------------ETAADEIVRWATPV- 313 Query: 369 MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISP 428 A D + + KG V++ + + +E+ + P F R NP Sbjct: 314 TAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPNP-------- 365 Query: 429 SVSYLPFGA-GPRSCIGEILARQELFLIMAWLLQRF 463 ++ FG G CIG LAR + LI + Sbjct: 366 ---HVGFGGTGAHYCIGANLARMTINLIFNAVADHM 398 >6F88-A nrPDB Length = 400 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 59/303 (19%), Positives = 111/303 (36%), Gaps = 49/303 (16%) Query: 194 ELNVIQNYNEGIIDNLSKDSLVDLVP-WLKIFPNK--------TLEKLKSHVKIRNDLLN 244 E ++ +E ++D L+ VDL+ + P + EKL + +L Sbjct: 101 EERFVRPISEQVVDRLAGKPRVDLLEDFAMELPRRVIGELFGFPAEKLHETDERVRAMLR 160 Query: 245 KILENYKEKFRSDSITNMLDTL--MQAKMNSDNGNAGPDQDSELL---------SDNHIL 293 ++ + ++S +TL + + ++ + E+L + Sbjct: 161 GLVRMHDPAAVAESQRAYGETLGLITEVVERESRDTSDTLLGEILRTLKAEHMDTIEASR 220 Query: 294 TTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLL 353 + + G ETT+ +V T+ LL +P ++ ++ LL Sbjct: 221 QIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQDP------------------SLL 262 Query: 354 EATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFM 413 A I E +R P + + D + + A+ GT V + A +++E + P+ + Sbjct: 263 PAAIEEGMRWCP-SNFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYD 321 Query: 414 PERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQL 473 +R PA FG G C+G LAR E + + LL RF + Sbjct: 322 IDRKPLPAANV----------FGGGAHFCVGAPLARMEARVGLQALLARFPGLRAVPEER 371 Query: 474 PSL 476 PS Sbjct: 372 PSF 374 >4DO1-A nrPDB Length = 410 Score = 128 bits (322), Expect = 5e-30, Method: Composition-based stats. Identities = 35/205 (17%), Positives = 80/205 (39%), Gaps = 37/205 (18%) Query: 283 DSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTP 342 D+ ++ + + + AG++TT + + + L P ++L Sbjct: 230 DTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRL-------------- 275 Query: 343 TISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHN 402 R+ L E +R + +G + +G +V++ L + + + Sbjct: 276 ----RSDPTLARNAFEEAVRFESPVQTF-FRTTTREVELGGAVIGEGEKVLMFLGSANRD 330 Query: 403 EKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 + W PD + R + ++ FG+G C+G+++AR E ++++ L ++ Sbjct: 331 PRRWSDPDLYDITR-----------KTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARK 379 Query: 463 ---FDLEVPD----DGQLPSLEGIP 480 D++ P + L LE +P Sbjct: 380 VAAIDIDGPVKRRFNNTLRGLESLP 404 >6G5O-A nrPDB Length = 399 Score = 127 bits (320), Expect = 9e-30, Method: Composition-based stats. Identities = 35/232 (15%), Positives = 89/232 (38%), Gaps = 42/232 (18%) Query: 239 RNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGD 298 + ++L ++ ++ + +M L+ ++ L+ + + Sbjct: 168 KANILYHYIDEQIDRASENPGDDMYSVLLNSEFE-----------GRKLTKEEVKGVMVL 216 Query: 299 IFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIR 358 F G +T + V ++A+L +P+ ++L +E + + + Sbjct: 217 TFAGGRDTVINAVTNSIAYLAEHPEALERLRKEPE------------------ITGRAVE 258 Query: 359 EVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 418 E++R + D+ + E AV + + + + + + + P++ + +R + Sbjct: 259 EMIRYFSPLTQ-MGRVVTEDTHVCEHAVKADSRISLCWASANRDAAVFENPNEIVLDRKV 317 Query: 419 NPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF-DLEVPD 469 NP ++ FG +C+G ARQ L +++ L Q+ E+ D Sbjct: 318 NP-----------HVGFGFSHHNCLGATHARQILKILLQTLAQKVASFEILD 358 >1WIY-A nrPDB Length = 389 Score = 127 bits (320), Expect = 9e-30, Method: Composition-based stats. Identities = 71/418 (16%), Positives = 131/418 (31%), Gaps = 81/418 (19%) Query: 72 TTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMAT 131 ++ + + L+ +G + A + D G W+ R+ Sbjct: 42 PLALIFDPEGVEGALLAEGTTKATFQYRALSRLTGRG----LLTDWGKSWKEARKALKDP 97 Query: 132 FALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNG 191 F + + + +E G+ D+ + ++ F Sbjct: 98 F--LPKSVRGYREAMEEEAWAFFGEWR---GEERDLDHEMLALSLRLLGRALFGK----- 147 Query: 192 DPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYK 251 L P L K L+++ + L + + Sbjct: 148 ------------------------PLSPSLAEHALKALDRI---MAQTRSPLALLDLAAE 180 Query: 252 EKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVV 311 +FR D + + L L+ + AG ET S + Sbjct: 181 ARFRKDR----------GALYREAEALIVHPPLSHLPRERALSEAVTLLVAGHETVASAL 230 Query: 312 KWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLI 371 W+ L H P +K++ E + + +E LRL P A +L Sbjct: 231 TWSFLLLSHRPDWQKRVAESEEAALAA------------------FQEALRLYPPAWIL- 271 Query: 372 PHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVS 431 + +GE + +GT ++++ + + + + F PERFL GT PS Sbjct: 272 TRRLERPLLLGEDRLPQGTTLVLSPYVTQRL--YFPEGEAFQPERFLAERGT----PSGR 325 Query: 432 YLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSF 489 Y PFG G R C+G A E +++ +RF L D P + + +V + Sbjct: 326 YFPFGLGQRLCLGRDFALLEGPIVLRAFFRRFRL---DPLPFPRV--LAQVTLRPEGG 378 >5DE9-A nrPDB Length = 410 Score = 127 bits (319), Expect = 1e-29, Method: Composition-based stats. Identities = 73/408 (17%), Positives = 134/408 (32%), Gaps = 77/408 (18%) Query: 61 GPIYSVRM--GTKTTVIVGHHQLAKEVLIKKG---KDFSGRPQMATLDIASNNRKGIAFA 115 GP+ + + G +V H + V + R R + F Sbjct: 37 GPVTRISLPNGEGWAWLVTRHDDVRLVTNDPRFGREAVMDRQVTRLAPHFRPARGAVGFL 96 Query: 116 DSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAV 175 D H +L R +A A G +++ + + L D + G D++ V Sbjct: 97 DPPDHTRLRRSVA---AAFTARGVERVRERSRGMLDELVDAMLRA-GPPADLTEAVLS-- 150 Query: 176 TNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSH 235 I++IC D + + + + I+ + + + Sbjct: 151 PFPIAVICELMGVPATDR--HSMHTWTQLILSSSHGAEVSE-------------RAKNEM 195 Query: 236 VKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTT 295 +DL+ RSDS + +L+ A + D ++ + + Sbjct: 196 NAYFSDLIG---------LRSDSAGEDVTSLLGAAVGRDE-----------ITLSEAVGL 235 Query: 296 IGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEA 355 + G E T+ LL P++ ++L E + Sbjct: 236 AVLLQIGG-EAVTNNSGQMFHLLLSRPELAERLRSEPEIR------------------PR 276 Query: 356 TIREVLRLRPV-APMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMP 414 I E+LR P + + A D I + G V ++ A + + + + PD+ Sbjct: 277 AIDELLRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDF 336 Query: 415 ERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQR 462 ER NP ++ FG GP C G +LAR E L++ +L R Sbjct: 337 ERSPNP-----------HVSFGFGPHYCPGGMLARLESELLVDAVLDR 373 >5HH3-A nrPDB Length = 397 Score = 126 bits (317), Expect = 2e-29, Method: Composition-based stats. Identities = 64/414 (15%), Positives = 119/414 (28%), Gaps = 78/414 (18%) Query: 69 GTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLA 128 G +T + + ++VL DFS R A G RR+ Sbjct: 50 GGRTAWLATGYDEIRQVL--SSDDFSARLLYGG-TAAGITWPGFLTQYDPPEHTRLRRMV 106 Query: 129 MATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSY 188 FA+ + QK + + + + D + G +D +V + Sbjct: 107 APAFAVRRM--QKFQPQVERVVQDSLDAIEALGG-PVDFVPRFGWSVATTATCDFLGIPR 163 Query: 189 KNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILE 248 + + ++T K N + + Sbjct: 164 DDQADLARSLHA-------------------------SRTERSGKRRTAAGNKFM-TYMN 197 Query: 249 NYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTT 308 + R D +M ++ + + ++D + + GAG + Sbjct: 198 KMTARTRRDPGDDMFGVVV-------------REYGDEITDAELTGVAAFVMGAGADQVA 244 Query: 309 SVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAP 368 + + +P+ L E+ D + + EV+R Sbjct: 245 RFLAAGAWLMADDPEQFALLREKPDTVPDW------------------LDEVIRYLTTDE 286 Query: 369 MLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQP-DQFMPERFLNPAGTQLIS 427 P A D IG+ + G V +L A + + + +P D+F R Sbjct: 287 KTHPRVATDDVRIGDHLIKAGDTVTCSLLAANR--RNFPRPEDRFDITR----------- 333 Query: 428 PSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF-DLEVPDDGQLPSLEGIP 480 +L FG G C+G LA + L RF L + + + L P Sbjct: 334 VRPEHLAFGHGIHHCLGRSLAELVFRTAIPALAHRFPTLRLAEPHREIRLGPPP 387 >6GII-A nrPDB Length = 479 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 56/433 (12%), Positives = 130/433 (30%), Gaps = 73/433 (16%) Query: 41 PFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVL----------IKKG 90 PF + F + ++ PI+ +V + K++ + + Sbjct: 71 PFQDAYMADPAQFVRWAREQVPIF--YAPKLNYWVVTRYDTIKQIFRDPVTFSPSNVLQS 128 Query: 91 KDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEI 150 L+ + RR+ M FA + + E ++ + + Sbjct: 129 FAQPSAEVRQVLERYGYAFNRTLVNEDEPMHLERRRVLMEPFA--SEHLAEHEPMVRELV 186 Query: 151 STLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLS 210 + G++ + ++ V + D E + Sbjct: 187 RRAVNRFIDT-GRADLVDQMIWEVPFTVALHFL---GVDDDDREKMRRFAIAHTVNA--- 239 Query: 211 KDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAK 270 + + P + L ++ + ++LE + + Sbjct: 240 ---------FGRPSPEEQLAVAETVGQFWQ-FCGEVLEKMRRTADGPGWM---------R 280 Query: 271 MNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYE 330 + PD +++D+++ + + I A ETT L LL + V +++ Sbjct: 281 YSIRQQKLYPD----VVTDSYLHSMMQAIIVAAHETTVFATTNALKTLLEHETVWREICA 336 Query: 331 EIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGT 390 + L+ A E LR + + + + G Sbjct: 337 DP------------------SLIPAAAEECLRYNGPVA-GWRRRTTREVEVEGVRLPVGA 377 Query: 391 EVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQ 450 +++ + + +H+ + P+ F R S + +L FG G C+G L R Sbjct: 378 NILMVVASANHDSAHFDDPEFFDIGR----------SNASEHLNFGYGAHQCLGRNLGRM 427 Query: 451 ELFLIMAWLLQRF 463 E+ +++ L +R Sbjct: 428 EMQIMIEELSRRL 440 >6HQD-A nrPDB Length = 420 Score = 126 bits (316), Expect = 3e-29, Method: Composition-based stats. Identities = 69/461 (14%), Positives = 146/461 (31%), Gaps = 78/461 (16%) Query: 41 PFLPRHGHMHNNFFKLQKK----------YGPIYSVRMGTKTTVIVGHHQLAKEVLIKKG 90 P L +H F +L+++ YGP +S+ + V + +V Sbjct: 26 PELFERDGLHPYFERLRREDPVHYCKASEYGPYWSITKFS-DIVAI---DTNHKVFSSDH 81 Query: 91 KDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEI 150 + S TL+ F R+ ++ ++ + E I + Sbjct: 82 TNGSFVLDDTTLNAVDGGIYLPNFLGMDPPKHDVHRMVVSPIVAPQNLLR-FEATIRERT 140 Query: 151 STLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLS 210 + L G+ + V + +T ++ + + + II Sbjct: 141 KRVLSELPI--GEEFNWVDRVSIELTTMMLATLLDFPFDDRRKLTRW-----SDIITTRP 193 Query: 211 KDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAK 270 LVD + E+ +S + ++ + +++ L + Sbjct: 194 GYGLVD-----------SWEQRESELMECLAYFQRLYAERQAMPPKP---DLISMLAHSP 239 Query: 271 MNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYE 330 D L+ L T+ + G +TT S + + PQ K+ Sbjct: 240 EMQD------------LTPTDFLGTLALLIVGGNDTTRSSMSGSAMACHLYPQEFDKV-- 285 Query: 331 EIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGT 390 RN LL + I EV+R + + A D + KG Sbjct: 286 ----------------RNNRALLASVIPEVVRWQTPIAH-MRRTALEDVEFRGKQIRKGD 328 Query: 391 EVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQ 450 +V++ + + +++ +P F+ +R + +L FG G C+G LA Sbjct: 329 KVVMWYLSGNRDDEVIDRPMDFIADR----------PRARHHLSFGFGIHRCLGNRLAEL 378 Query: 451 ELFLIMAWLLQRF-DLEVPDDGQLPSLEGIPKVVFLIDSFK 490 +L ++ + +R+ +EV + + + + Sbjct: 379 QLKILWEEMCERYSRIEVCGEPVRVPSNLVHGYIDIPVRLH 419 >2UUQ-A nrPDB Length = 414 Score = 125 bits (313), Expect = 5e-29, Method: Composition-based stats. Identities = 58/373 (15%), Positives = 121/373 (32%), Gaps = 67/373 (17%) Query: 99 MATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLA 158 L++ + R+L F + +E + + + + L Sbjct: 82 YGELEMIGLHDTPPMVMQDPPVHTEFRKLVSRGFT--PRQVETVEPTVRKFVVERLEKLR 139 Query: 159 THNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLV 218 + G DI +F + +++ PE + Q +G + + VD Sbjct: 140 ANGGG--DIVTELFKPLPSMVVAHYLGV------PEEDWTQ--FDGWTQAIVAANAVD-- 187 Query: 219 PWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNA 278 T L V ++ E+ R++ + + L+ A + +D A Sbjct: 188 -------GATTGAL-DAVGSMMAYFTGLI----ERRRTEPADDAISHLVAAGVGADGDTA 235 Query: 279 GPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGF 338 G IL + G +T T ++ ++ L P ++ L ++ + Sbjct: 236 GTLS---------ILAFTFTMVTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEG---- 282 Query: 339 SRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWA 398 + + E+LRL + D +IG+ + G V++ + Sbjct: 283 --------------IPDAVEELLRLTSPV-QGLARTTTRDVTIGDTTIPAGRRVLLLYGS 327 Query: 399 LHHNEKEW-HQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMA 457 + +E+++ + R + L F G C+G AR + + + Sbjct: 328 ANRDERQYGPDAAELDVTRCP-----------RNILTFSHGAHHCLGAAAARMQCRVALT 376 Query: 458 WLLQRF-DLEVPD 469 LL R D EV + Sbjct: 377 ELLARCPDFEVAE 389 >3WEC-A nrPDB Length = 419 Score = 124 bits (312), Expect = 6e-29, Method: Composition-based stats. Identities = 53/289 (18%), Positives = 98/289 (33%), Gaps = 46/289 (15%) Query: 206 IDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLN--KILENYKEKFRSDSITNML 263 + +++ V+++ + P+K + + +L+ + RS +I + Sbjct: 149 VSEVAEPFPVEVLSSILGIPDKDRGRFSEWSNLVAGVLDINFAIPKEVADRRSAAIEESI 208 Query: 264 DTLMQAKMNSDNGNAGPD------QDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAF 317 D + + + LS + I T I AG ETT++ + L Sbjct: 209 DYFRTLATSGNAPEGLVRRLSEVSHGGDQLSVDEIAATCLLITVAGQETTSNTIGNMLIT 268 Query: 318 LLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANV 377 + +++ R +E + EVLR P A A Sbjct: 269 FSRHADQFEQV------------------RANPQFIENAVAEVLRFEPPAHEA-GRIALE 309 Query: 378 DSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGA 437 D + + KG V++ L + + + + D F R P VS L +G Sbjct: 310 DCEVSGANITKGDAVMVLLASGNR--EAVERGDTFSVTR-----------PDVSSLSYGR 356 Query: 438 GPRSCIGEILARQELFLIMAWLLQRFD-LEVPDDGQLPSLEGIPKVVFL 485 G C+G LA L + L QR+ +EV + + P + Sbjct: 357 GIHHCLGSALANSMLQHFLRELSQRYRSIEVAEP-----INYKPGMGLR 400 >3OO3-A nrPDB Length = 384 Score = 124 bits (311), Expect = 9e-29, Method: Composition-based stats. Identities = 62/401 (15%), Positives = 122/401 (30%), Gaps = 85/401 (21%) Query: 76 VGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALF 135 V H + +L + S RP D A GI A RR ++ Sbjct: 44 VTGHDEVRAILADHERFSSMRPVDDEADRAL--LPGILQAYDPPDHTRLRRTVAPAYSAR 101 Query: 136 KDGDQKLEKIICQEISTLCDMLATHNGQSIDI-SFPVFVAVTNVISLICFNTSYKNGDPE 194 + ++L I + + D + G +D + + F ++ E Sbjct: 102 RM--ERLRPRIEEIVEECLDDFESV-GAPVDFVRHAAWPIPAYIACE--FLGVPRDDQAE 156 Query: 195 LNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKI-LENYKEK 253 L+ + + + + R L+ + + NY ++ Sbjct: 157 LSRM------------------------------IRESRESRLPRQRTLSGLGIVNYTKR 186 Query: 254 FRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313 S + D ++ + + +SD + E + + Sbjct: 187 LTSGKRRDPGDGMIGVIV---------REHGAEISDEELAGLAEGNLIMAAEQMAAQLAV 237 Query: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 373 + L+ +P L E + L+++ EVLR + P Sbjct: 238 AVLLLVTHPDQMALLRE------------------KPELIDSATEEVLRHASIVEAPAPR 279 Query: 374 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYL 433 A D + + G + ++ A + D+F R +++ Sbjct: 280 VALADVRMAGRDIHAGDVLTCSMLATNRAP-----GDRFDITR-----------EKATHM 323 Query: 434 PFGAGPRSCIGEILARQELFLIMAWLLQRF---DLEVPDDG 471 FG G CIG LAR +L + + ++ RF L VP++ Sbjct: 324 AFGHGIHHCIGAPLARLQLRVALPAVVGRFPSLRLAVPEED 364 >3AWQ-A nrPDB Length = 415 Score = 123 bits (309), Expect = 2e-28, Method: Composition-based stats. Identities = 35/152 (23%), Positives = 63/152 (41%), Gaps = 13/152 (8%) Query: 347 RNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEW 406 + E ++EV R P P ++ A+ D A +G +V+++L+ +H+ W Sbjct: 268 VQQPDYAELFVQEVRRFYPFFPAVVAR-ASQDFEWEGMAFPEGRQVVLDLYGSNHDAATW 326 Query: 407 HQPDQFMPERFLNPAGTQLISPSVSYLPFGAGP----RSCIGEILARQELFLIMAWLLQR 462 P +F PERF S +++P G G C GE + + + L+ Sbjct: 327 ADPQEFRPERF-----RAWDEDSFNFIPQGGGDHYLGHRCPGEWIVLAIMKVAAHLLVNA 381 Query: 463 FDLEVPDDG---QLPSLEGIPKVVFLIDSFKV 491 +VPD L +PK F++ + + Sbjct: 382 MRYDVPDQDLSIDFARLPALPKSGFVMRNVHI 413 >5H1Z-A nrPDB Length = 407 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 43/269 (15%), Positives = 94/269 (34%), Gaps = 44/269 (16%) Query: 205 IIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLD 264 +D +S + ++ L FP + KL +D I E+ R + + +M + Sbjct: 141 WVDTVSVELTTQMLAILFDFPWEERRKLTFW----SDWAGDIELVKNEELRLERLRHMYE 196 Query: 265 T------LMQAKMNSDNGNAG-----PDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313 L AK+ + L + + G +TT + + Sbjct: 197 CGGYFQNLWNAKIGKPPTPDLISMMIHSDAMAEMDQMEFLGNLILLIVGGNDTTRNTMSA 256 Query: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 373 L P + KL + ++ T++E++R + + Sbjct: 257 VAYGLDLFPDQRAKLEADP------------------SMIPNTVQEIIRWQTPLAH-MRR 297 Query: 374 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYL 433 A VDS + + G ++ + + + +E + D+ + +R + +L Sbjct: 298 TATVDSELEGQQIKAGDKLALWYISANRDESVFENADRIIVDR----------PNARRHL 347 Query: 434 PFGAGPRSCIGEILARQELFLIMAWLLQR 462 FG G C+G LA ++ +++ + +R Sbjct: 348 AFGHGIHRCVGARLAELQIAVLLEEMAKR 376 >4PWV-A nrPDB Length = 446 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 52/341 (15%), Positives = 104/341 (30%), Gaps = 50/341 (14%) Query: 163 QSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLK 222 + V N L+ D +V + I +L D +L Sbjct: 138 SPQALKPIVDQIRVNTTRLVVDAARRGECDFAADVAEQIPLNTISDLLGVPAADR-EFLL 196 Query: 223 IFPNKTLEKLKSHVKIRNDLLNK-----ILENYKEKFRSDSITNMLDTLMQAKMNSDNGN 277 L + + L + + R+ +++ L + + Sbjct: 197 KLNKSALSSEDADQSATDAWLARNEILLYFSELVAERRAKPTEDVISVLANSMV------ 250 Query: 278 AGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVG 337 D + L++ I+ + G ET+ + ++ P + L + Sbjct: 251 -----DGKPLTEEVIVLNCYSLILGGDETSRLSMIDSVQTFTQYPDQWELLRDGKVT--- 302 Query: 338 FSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLW 397 LE+ EVLR A M +A D + + G V + Sbjct: 303 ---------------LESATEEVLRWATPA-MHFGRRAVTDMELHGQVIAAGDVVTLWNN 346 Query: 398 ALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMA 457 + + +E+ + P F R N ++ FG GP C+G L R E+ ++ Sbjct: 347 SANRDEEVFADPYAFDLNRSPN-----------KHITFGYGPHFCLGAYLGRAEVHALLD 395 Query: 458 WLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQA 498 L + + G+ + + + V+I+ +A Sbjct: 396 AL-RTYTTGFEITGEPQRIHSNF--LTGLSRLPVRIQPNEA 433 >2WIY-A nrPDB Length = 394 Score = 122 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 58/355 (16%), Positives = 115/355 (32%), Gaps = 63/355 (17%) Query: 110 KGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISF 169 A H + RR F + + + L D + GQ I+ Sbjct: 76 SDTALGSDPPHHTVLRRQTNKWFT--PKLVDGWVRTTRELVGDLLDGVEA--GQVIEARR 131 Query: 170 PVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTL 229 + V T+V + D V++ E ++ ++ + D+ Sbjct: 132 DLAVVPTHVTMARVLQLPEDDADA---VMEAMFEAMLMQSAEPADGDV------------ 176 Query: 230 EKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSD 289 + L+ + E R + + D+L+ A + +++ Sbjct: 177 ----DRAAVAFGYLSARVAEMLEDKRVNPGDGLADSLLDAARAGE------------ITE 220 Query: 290 NHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNR 349 + + TI + G ++ + P+V + RN Sbjct: 221 SEAIATILVFYAVGHMAIGYLIASGIELFARRPEVF------------------TAFRND 262 Query: 350 LLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQP 409 A I E++R+ P + D IG ++ G+ + + A + + + + P Sbjct: 263 ESARAAIINEMVRMDPP-QLSFLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDP 321 Query: 410 DQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFD 464 D F R + L FG GP SC G+I++R E + A L +R++ Sbjct: 322 DVFDHTRPPAASRN---------LSFGLGPHSCAGQIISRAEATTVFAVLAERYE 367 >2IJ7-A nrPDB Length = 396 Score = 122 bits (305), Expect = 5e-28, Method: Composition-based stats. Identities = 51/210 (24%), Positives = 83/210 (39%), Gaps = 31/210 (14%) Query: 267 MQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKK 326 + + + D +SD T FGAGV +T S + L L+ PQ++ Sbjct: 198 ITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRN 257 Query: 327 KLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAV 386 L+E + L+ A + E+LR+ +P A D +G+ V Sbjct: 258 LLHE------------------KPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLV 299 Query: 387 DKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEI 446 KG V++ L + + + + P +R NP S+L FG G C G Sbjct: 300 RKGELVLVLLEGANFDPEHFPNPGSIELDR-PNP---------TSHLAFGRGQHFCPGSA 349 Query: 447 LARQELFLIMAWLLQRF---DLEVPDDGQL 473 L R+ + + LL++ DL VP D + Sbjct: 350 LGRRHAQIGIEALLKKMPGVDLAVPIDQLV 379 >5M0P-A nrPDB Length = 428 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 45/190 (23%), Positives = 74/190 (38%), Gaps = 31/190 (16%) Query: 311 VKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPML 370 V + L + NP ++K+ E D F++ EV R P P L Sbjct: 260 VSFGLHAMNENPITREKIKSEPDYAYKFAQ------------------EVRRYYPFVPFL 301 Query: 371 IPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSV 430 P KA VD + G + ++++ H+E W P++F PERF G+ Sbjct: 302 -PGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRPERFETWDGSPFDL--- 357 Query: 431 SYLPFGAGP----RSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVV--- 483 +P G G C GE + + M + ++ +VP+ L IP V Sbjct: 358 --IPQGGGDYWTNHRCAGEWITVIIMEETMKYFAEKITYDVPEQDLEVDLNSIPGYVKSG 415 Query: 484 FLIDSFKVKI 493 F+I + + + Sbjct: 416 FVIKNVREVV 425 >2NZA-A nrPDB Length = 413 Score = 118 bits (296), Expect = 5e-27, Method: Composition-based stats. Identities = 74/462 (16%), Positives = 137/462 (29%), Gaps = 86/462 (18%) Query: 19 KRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRM--GTKTTVIV 76 + + P + P L G + + GP+ VR+ G + Sbjct: 4 ETTTLTGQSPPPVRDWP------ALDLDGPEFDPVLAELMREGPLTRVRLPHGEGWAWLA 57 Query: 77 GHHQLAKEVLIKKG---KDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFA 133 + K + + + R +AFAD H RR F Sbjct: 58 TRYDDVKAITNDPRFGRAEVTQRQITRLAPHFKPRPGSLAFADQPDH-NRLRRAVAGAFT 116 Query: 134 LFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDP 193 + ++L + + L D + G D+ V I+++ D Sbjct: 117 VG--ATKRLRPRAQEILDGLVDGILAE-GPPADLVERVLE--PFPIAVVSEVMGVPAADR 171 Query: 194 ELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK 253 E + ++ II + + + L I E + + Sbjct: 172 ER--VHSWTRQIISTSGGAEAAE--------------------RAKRGLYGWITETVRAR 209 Query: 254 FRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 313 S+ ++ L A + G + + G + G E T V Sbjct: 210 AGSE-GGDVYSMLGAAVGRGEVG------------ETEAVGLAGPLQIGG-EAVTHNVGQ 255 Query: 314 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPV-APMLIP 372 L LL ++ ++ E + E+LR + + Sbjct: 256 MLYLLLTRRELMARMRERPGAR------------------GTALDELLRWISHRTSVGLA 297 Query: 373 HKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSY 432 A D + + G V ++ A + + + PD+ +R NP + Sbjct: 298 RIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDRDPNP-----------H 346 Query: 433 LPFGAGPRSCIGEILARQELFLIMAWLLQR---FDLEVPDDG 471 L +G G C G +LAR + L++ LL+R L VP + Sbjct: 347 LAYGNGHHFCTGAVLARMQTELLVDTLLERLPGLRLAVPAEQ 388 >3BUJ-A nrPDB Length = 397 Score = 117 bits (294), Expect = 8e-27, Method: Composition-based stats. Identities = 42/172 (24%), Positives = 65/172 (37%), Gaps = 30/172 (17%) Query: 280 PDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFS 339 D L+S N I++T+ G ET S V + LL +P L D Sbjct: 211 DAHDRGLMSRNEIVSTVVTFIFTGHETVASQVGNAVLSLLAHPDQLDLLRRRPD------ 264 Query: 340 RTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWAL 399 LL + E LR P + +VD + + + V++ A Sbjct: 265 ------------LLAQAVEECLRYDPSVQSN-TRQLDVDVELRGRRLRRDDVVVVLAGAA 311 Query: 400 HHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQE 451 + + + + +PD F ER P+ + FGAG R C+G LAR + Sbjct: 312 NRDPRRYDRPDDFDIERDPVPS-----------MSFGAGMRYCLGSYLARTQ 352 >6BLD-A nrPDB Length = 419 Score = 116 bits (290), Expect = 3e-26, Method: Composition-based stats. Identities = 62/364 (17%), Positives = 114/364 (31%), Gaps = 60/364 (16%) Query: 113 AFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVF 172 A R+L A F +++E I + D L G + F Sbjct: 102 FLAMDPPRHTKLRKLVSAAFT--PRQVRRIEDSIKINAKGIVDELRMAGGG---VDFVEH 156 Query: 173 VAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKL 232 A I + D E + + + ++ L P +F N+ Sbjct: 157 CAKELPIRTLSDMVGIPEADRER--VAHAADALVSWADPRYLNGREPLAVLFENQM---- 210 Query: 233 KSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292 L+++ + + R ++ L+ A++ D + L+D + Sbjct: 211 ---------YLHQVAASLAAERRDRPGDDLFSALVNAEV-----------DGDRLADADV 250 Query: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352 + AG +TT + L L P K L + D +G Sbjct: 251 AAFFVLLAVAGNDTTRQTISHGLKALTDFPSQKAWLLADFDTRIG--------------- 295 Query: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412 + E++R M A D +G + G +V++ + + +E + P++ Sbjct: 296 --TAVEELVRWATPV-MTFRRTAAADFELGGQLIRAGEKVVMFYASGNWDEDAFCHPERL 352 Query: 413 MPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF-DLEVPDDG 471 R NP C+G LAR +L I LL + D++ D Sbjct: 353 DLSRSPNPHVGFGGGGVHF----------CLGAHLARAQLRAIFGELLVQLPDIQAGDPV 402 Query: 472 QLPS 475 +P Sbjct: 403 YVPG 406 >4FB2-A nrPDB Length = 398 Score = 115 bits (288), Expect = 4e-26, Method: Composition-based stats. Identities = 43/398 (10%), Positives = 125/398 (31%), Gaps = 63/398 (15%) Query: 78 HHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKD 137 + +D + + + + + + A Q + + + Sbjct: 16 GPDGTPHAFFEALRDEAETTPIGWSEAYGGHWVVAGYKEIQAVIQNTKAFSNKGVTFPRY 75 Query: 138 GDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNV 197 + E ++ + + + T++ + ++ D + + Sbjct: 76 ETGEFELMMAGQDDPVHKKYRQLVAKPFSPE------ATDLFTEQLRQSTNDLIDARIEL 129 Query: 198 IQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHV---------KIRNDLLNKILE 248 + + N L L P + + + V + ++ +++ Sbjct: 130 GEGDAATWLANEI---PARLTAILLGLPPEDGDTYRRWVWAITHVENPEEGAEIFAELVA 186 Query: 249 NYK---EKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVE 305 + + + R++ +++ ++ +K+ D E LS++ ++ + G++ Sbjct: 187 HARTLIAERRTNPGNDIMSRVIMSKI-----------DGESLSEDDLIGFFTILLLGGID 235 Query: 306 TTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRP 365 T + L + +++++L + L+ + E+LR Sbjct: 236 NTARFLSSVFWRLAWDIELRRRLIAHPE------------------LIPNAVDELLRFY- 276 Query: 366 VAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQL 425 P ++ + ++G+ + G ++ + + PD + ER N Sbjct: 277 -GPAMVGRLVTQEVTVGDITMKPGQTAMLWFPIASRDRSAFDSPDNIVIERTPN------ 329 Query: 426 ISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 +L G G C+G L R E + + L+R Sbjct: 330 -----RHLSLGHGIHRCLGAHLIRVEARVAITEFLKRI 362 >5EX8-A nrPDB Length = 424 Score = 115 bits (287), Expect = 6e-26, Method: Composition-based stats. Identities = 47/294 (15%), Positives = 88/294 (29%), Gaps = 39/294 (13%) Query: 196 NVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNK--TLEKLKSHVKIRNDLLNKILENYKEK 253 ++Q+ + I V W P L + +L + +K Sbjct: 151 QIVQDSLDTIESLGGPVDFVPHFGWAIATPATCDFLGIPRDDQADLARILLASRTDRSDK 210 Query: 254 FRSDSITNMLDTLMQAKMNSDNGNAGP------DQDSELLSDNHILTTIGDIFGAGVETT 307 R+ + + + Q S G+ ++ + ++D + + GA + Sbjct: 211 RRTAAGNKFMTYMKQHVAQSRRGSGDDLFGIVGRENGDAITDAELTGVAAFVMGAAADQV 270 Query: 308 TSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVA 367 ++ ++ P L E+ + + + E +R Sbjct: 271 ARLLAAGAWLMVEQPAQFALLREKPETVPEW------------------LDETMRYLTTD 312 Query: 368 PMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLIS 427 P A D IG V G V +L A + D+F R Sbjct: 313 EKTHPRVATQDVRIGNQLVKAGDTVTCSLLAANR-PNYPSAEDEFDITR----------- 360 Query: 428 PSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF-DLEVPDDGQLPSLEGIP 480 +L FG G C+G +A + + L RF L + D + +L P Sbjct: 361 EKAEHLAFGHGIHHCLGRAMAELMFKVSIPALAHRFPTLRLADPQREITLGPPP 414 >3OFT-A nrPDB Length = 396 Score = 114 bits (286), Expect = 7e-26, Method: Composition-based stats. Identities = 46/271 (16%), Positives = 88/271 (32%), Gaps = 38/271 (14%) Query: 199 QNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDS 258 + E + S D + D L + TL + + R L L + Sbjct: 122 RKLMESLRPRGSCDFVSDFAEILPLNIFLTLIDVPLEDRPRLRQLGVQLTRPDGSMTVEQ 181 Query: 259 ITNMLDTLMQAKMNSDNGNAGPDQDSELLSD---------NHILTTIGDIFGAGVETTTS 309 + D + + G D S +LS+ + ++ G++T + Sbjct: 182 LKQAADDYLWPFIEKRMAQPGDDLFSRILSEPVGGRPWTVDEARRMCRNLLFGGLDTVAA 241 Query: 310 VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPM 369 ++ L +P+ ++ L E D L+ A E++R P Sbjct: 242 MIGMVALHLARHPEDQRLLRERPD------------------LIPAAADELMRRYPTV-- 281 Query: 370 LIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPS 429 + A D + KG V + + + + P++ +R L P Sbjct: 282 AVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGLAP--------- 332 Query: 430 VSYLPFGAGPRSCIGEILARQELFLIMAWLL 460 + + G G C+G LAR E+ + + L Sbjct: 333 IRHTTMGVGAHRCVGAGLARMEVIVFLREWL 363 >5KYO-A nrPDB Length = 430 Score = 111 bits (277), Expect = 8e-25, Method: Composition-based stats. Identities = 51/395 (12%), Positives = 116/395 (29%), Gaps = 75/395 (18%) Query: 91 KDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRL-AMATFALFKDGDQKLEKIICQE 149 + FS + + A + I + HR ++ L + +E+++ Sbjct: 100 ERFSNHTVLVPKETAGEAYRLIPLSLDPPE---HRPFRSLLNENLGPKPLRPIEQVVTDL 156 Query: 150 ISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNL 209 +L + + F + V F +L +++ + Sbjct: 157 AVSLIEGFRPKGRCNFTHEFAEQLPVR------IFMRIVDLPVEDLPKLKHLADQYTRPD 210 Query: 210 SKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQA 269 L D+ + + + E R +M+ ++ Sbjct: 211 GSIPLDDVTKQFREYLRPVI----------------------EARRIKPGEDMISRMING 248 Query: 270 KMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLY 329 ++ L+D + G++T +++ +T + L + +++ + Sbjct: 249 EVG-----------GRPLTDIEAENICIQVLVGGLDTVVNMLGFTFSHLAKDHALRRAIA 297 Query: 330 EEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKG 389 + L++ + E R PV + D + G Sbjct: 298 ADP------------------SLIDDALLEFFRRFPVVSS--AREVLRDQEFEGVLLKAG 337 Query: 390 TEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILAR 449 V+ + ++ P +F R + + FG G +C G LAR Sbjct: 338 DMVMAPTVVVAMDDARNEDPLEFRLGR-----------KARQHSTFGKGSHTCPGAHLAR 386 Query: 450 QELFLIMAWLLQRF-DLEVPDDGQLPSLEGIPKVV 483 E+ +++ R + + DD L GI V Sbjct: 387 MEMKVVLREWFARIPEFRIEDDAPLRYSNGIVGSV 421 >6G71-A nrPDB Length = 405 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 44/282 (15%), Positives = 96/282 (34%), Gaps = 38/282 (13%) Query: 205 IIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLD 264 + + + + + L F N + L+ + D ++ ++ ++ +D Sbjct: 132 FMQGFAAPFVAENLRALIGFENASEADLQRWSQTLIDGAGNYPDDPDVWAKAKQSSDEID 191 Query: 265 TLMQAKMNSDNGNAGP-------DQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAF 317 ++ + +G G + I + I G G+ V+ + Sbjct: 192 AALEEMIQWHSGRPGDSLLSYLLRSADYQMPLESIRSNIKMTIGGGLNEPRDVLGVSTLA 251 Query: 318 LLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANV 377 LL + + + + + L A E +R M +P + V Sbjct: 252 LLSSSKQLELVLRDPK------------------LWGAVFEESIRWVAPIGM-VPRQTVV 292 Query: 378 DSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGA 437 D+ + + + +G ++ + + + + + W PD+F ER S ++L FG Sbjct: 293 DTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRFDIER-----------GSEAHLAFGK 341 Query: 438 GPRSCIGEILARQE-LFLIMAWLLQRFDLEVPDDGQLPSLEG 478 G C+G AR + + + L R D Q + G Sbjct: 342 GVHVCLGAWAARSQVADVGLPALFSRLKGLRLDPNQEATHGG 383 >5YHJ-A nrPDB Length = 413 Score = 107 bits (267), Expect = 1e-23, Method: Composition-based stats. Identities = 54/289 (18%), Positives = 107/289 (37%), Gaps = 39/289 (13%) Query: 218 VPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDS-ITNMLDTLMQAKMNSDNG 276 VP K K E+++ + L L+ K + ++ I M+ + ++ + Sbjct: 149 VPLAKEEVGKRTEEMRLLFESGTSLGPTYLQGRKARSSAEVWIRQMVKEVRSNRLLPNEH 208 Query: 277 NA------GPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYE 330 A D+ ELL + + + +I V + V+ +T+ L P VK+++ Sbjct: 209 TALYEFSWHRDESGELLPEEVVAVEVLNILRPTVAISVYVL-FTVLALHQFPDVKEQV-- 265 Query: 331 EIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGT 390 +R + E ++EV R P P+ D +A +GT Sbjct: 266 ---------------ERGEVSKTE-FVQEVRRFYPFFPVAAAR-VKTDFEWDGYAFPEGT 308 Query: 391 EVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGP----RSCIGEI 446 +++L+ +H+ W +PD+F P RF + + +++P G G C GE Sbjct: 309 LTLLDLYGTNHDVSIWTEPDRFDPSRFKDWKESP-----FNFIPQGGGDVDFGHRCAGEH 363 Query: 447 LARQELFLIMAWLLQRFDLEVPDDG---QLPSLEGIPKVVFLIDSFKVK 492 + L ++ + + VP + +PK + Sbjct: 364 VTIAILAQVIELFTKEYAYTVPPQDLSYSFVDMPSLPKSKLRLTHLTRN 412 >5OMS-A nrPDB Length = 409 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 46/375 (12%), Positives = 113/375 (30%), Gaps = 56/375 (14%) Query: 90 GKDFSGRPQMATLDIASNNR---KGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKII 146 ++ + P + + R +G R + + D+ ++ ++ Sbjct: 56 CREVATSPDFEAVITPAGGRTFGHPAIIGVNGDIHADLRSMVEPALQ-PAEVDRWIDDLV 114 Query: 147 CQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGII 206 + + + V+V ++ + D N Sbjct: 115 RPIARRYLERFENDGHAELVAQYCEPVSVRSL--GDLLGLQEVDSDKLREWFAKLNRSFT 172 Query: 207 DNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTL 266 + ++ P + + +++ +++ + E +I++ L Sbjct: 173 NAAVDENGEFANP-------EGFAEGDQAKAEIRAVVDPLIDKWIEHPDDSAISHWLH-- 223 Query: 267 MQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKK 326 D G +D E + + +G + G + TL L P+ + Sbjct: 224 -------DGMPPGQTRDREYIYPTIYVYLLGAMQEPGH-----GMASTLVGLFSRPEQLE 271 Query: 327 KLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAV 386 ++ ++ L+ I E LR + +I + Sbjct: 272 EVVDDP------------------TLIPRAIAEGLRWTSPIWSATARISTKPVTIAGVDL 313 Query: 387 DKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEI 446 GT V+++ + +H+ ++ P Q+ R P + +L FGAG +C G Sbjct: 314 PAGTPVMLSYGSANHDTGKYEAPSQYDLHR-----------PPLPHLAFGAGNHACAGIY 362 Query: 447 LARQELFLIMAWLLQ 461 A + + + L + Sbjct: 363 FANHVMRIALEELFE 377 >2QBO-A nrPDB Length = 421 Score = 105 bits (263), Expect = 3e-23, Method: Composition-based stats. Identities = 59/404 (14%), Positives = 125/404 (30%), Gaps = 81/404 (20%) Query: 80 QLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGD 139 QL +E + FS + + F + R+ + Sbjct: 70 QLIREAYEDY-RHFSSECPFIPREA----GEAYDFIPTSMDPPEQRQFRALANQVVGMPV 124 Query: 140 Q-KLEKIICQEISTLCDMLATHN--GQSIDISFPVFVAVTNVISLICFNTSYKNGDPELN 196 KLE I + +L + L + D + P + F + ++ Sbjct: 125 VDKLENRIQELACSLIESLRPQGQCNFTEDYAEPFPIR--------IFMLLAGLPEEDIP 176 Query: 197 VIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRS 256 ++ + + + + D L I+E ++K + Sbjct: 177 HLKYLTDQMTRPDGSMTFA------------------EAKEALYDYLIPIIEQRRQKPGT 218 Query: 257 DSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLA 316 D+I + A + ++ + G + G++T + + +++ Sbjct: 219 DAI---------------SIVANGQVNGRPITSDEAKRMCGLLLVVGLDTVVNFLSFSME 263 Query: 317 FLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKAN 376 FL +P+ +++L E ++ + A E+LR + Sbjct: 264 FLAKSPEHRQELIERPER------------------IPAACEELLRRFSLVADG--RILT 303 Query: 377 VDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFG 436 D + KG ++++ +E+E P VS+ FG Sbjct: 304 SDYEFHGVQLKKGDQILLPQMLSGLDERE-----------NACPMHVDFSRQKVSHTTFG 352 Query: 437 AGPRSCIGEILARQELFLIMAWLLQRF-DLEVPDDGQLPSLEGI 479 G C+G+ LAR+E+ + + L R D + Q+ GI Sbjct: 353 HGSHLCLGQHLARREIIVTLKEWLTRIPDFSIAPGAQIQHKSGI 396 >5D3U-A nrPDB Length = 427 Score = 99.8 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 32/187 (17%), Positives = 59/187 (31%), Gaps = 30/187 (16%) Query: 278 AGPDQDSELLSDNHILTTIGDIFGAGVE-TTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV 336 A + + + +F A TT + NP+ ++ + Sbjct: 242 AAAQDGLTETTPEQTVHQLALVFIALFAPTTPGSLSSGTLAFARNPRQVERFLADQACV- 300 Query: 337 GFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINL 396 + T EVLR + A D +G ++ G + + L Sbjct: 301 -----------------DNTANEVLRYN-ASNQFTWRVAAKDVEMGGVRIEAGQTLALFL 342 Query: 397 WALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIM 456 + + + + +P+ F +R S +L FG G +C+ L +L Sbjct: 343 GSANRDANMFERPNDFDLDR----------PNSARHLSFGQGVHACLAAQLISLQLKWFY 392 Query: 457 AWLLQRF 463 LL RF Sbjct: 393 VALLNRF 399 >2IAG-A nrPDB Length = 482 Score = 99.4 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 77/509 (15%), Positives = 159/509 (31%), Gaps = 68/509 (13%) Query: 20 RRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHH 79 R + P L S+P +G + + ++++K+G I+++ +G + ++ Sbjct: 1 RTRRPGEPPLDLGSIPWLGYALDFGKDA--ASFLTRMKEKHGDIFTILVGGRYVTVLLDP 58 Query: 80 QLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFAD-----SGAHWQLHRRLAMATFAL 134 V + I + H+ A L Sbjct: 59 HSYDAV------------VWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTL 106 Query: 135 FKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISL---ICFNTSYKNG 191 Q L + + + + AT G + + + ++ + Sbjct: 107 LHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPR 166 Query: 192 DPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKL----KSHVKIRNDLLNKIL 247 E + S D ++ P L K H+ L K+L Sbjct: 167 THESQAQDRVH-------SADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLL 219 Query: 248 ENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETT 307 + R+ + L+ + +S+ + A Sbjct: 220 SPARLARRAHRSKWLESYLLHLEEMG-------------VSEEMQARALVLQLWATQGNM 266 Query: 308 TSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISD-------RNRLLLLEATIREV 360 W L FLL NP+ + E++ + + P + +L++ + E Sbjct: 267 GPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSES 326 Query: 361 LRLRPVAPMLIPHKANVDSSI-----GEFAVDKGTEVIINL-WALHHNEKEWHQPDQFMP 414 LRL A I + VD ++ EF + +G +++ + + + + P+ F Sbjct: 327 LRLT--AAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKY 384 Query: 415 ERFLNPAGTQLISPS-------VSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEV 467 RFLNP G++ +P+GAG C+G A + + +L DLE+ Sbjct: 385 NRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLEL 444 Query: 468 PDDGQLPSLEGIPKVVFLIDSFKVKIKVR 496 + + + F + + + VR Sbjct: 445 INADVEIPEFDLSRYGFGLMQPEHDVPVR 473 >3B98-A nrPDB Length = 475 Score = 93.7 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 73/485 (15%), Positives = 143/485 (29%), Gaps = 49/485 (10%) Query: 15 LFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTV 74 + + +R + P +P +G + ++++K+G I++VR Sbjct: 8 VLYGRRTRRRNEPPLDKGMIPWLGHALEFGKDA--AKFLTRMKEKHGDIFTVRAAGLYIT 65 Query: 75 IVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFAL 134 ++ VL D + Q + + + + R A Sbjct: 66 VLLDSNCYDAVL----SDVASLDQTSYAQVLMKRIFNMILPSHNPESEKKRAEMHFQGAS 121 Query: 135 FKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE 194 + + L S +F +++ + T + + Sbjct: 122 LTQLSNSM----QNNLRLLMTPSEMGLKTSEWKKDGLFNLCYSLLFKTGYLTVFGAENNN 177 Query: 195 LNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKF 254 + E L T+ K +I + K+ + Sbjct: 178 SAALTQIYEEFRR---------FDKLLPKLARTTVN--KEEKQIASAAREKLWKWLTPSG 226 Query: 255 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314 K D G Q +L + AG W Sbjct: 227 LDRKPREQSWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQG-----NAG-----PAAFWV 276 Query: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHK 374 + +LL +P+ + + EEI G + + ++ + E LRL A LI Sbjct: 277 MGYLLTHPEALRAVREEIQ---GGKHLRLEERQKNTPVFDSVLWETLRLT--AAALITRD 331 Query: 375 ANVDSSI-----GEFAVDKGTEVIINLW-ALHHNEKEWHQPDQFMPERFLNPAGTQLISP 428 D I E+ + +G + + + + + + QP+ F +RFLN T+ Sbjct: 332 VTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDF 391 Query: 429 -------SVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPK 481 +P+G C G A + ++ +L RFD+E+ D L + Sbjct: 392 FKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSR 451 Query: 482 VVFLI 486 F I Sbjct: 452 YGFGI 456 >3NV6-A nrPDB Length = 452 Score = 90.6 bits (223), Expect = 2e-18, Method: Composition-based stats. Identities = 40/288 (13%), Positives = 91/288 (31%), Gaps = 46/288 (15%) Query: 191 GDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENY 250 D V + + D + + L L + + Sbjct: 164 EDKVREVASSLIDSFAARGECDFAAEYAELFPVHVFMALADLPLEDIPVLSEYARQMTRP 223 Query: 251 KEKFRSDSITNM----------LDTLMQAKMNSDNGN-----AGPDQDSELLSDNHILTT 295 + + T++ +D +++A++ D + + + E ++ + Sbjct: 224 EGNTPEEMATDLEAGNNGFYAYVDPIIRARVGGDGDDLITLMVNSEINGERIAHDKAQGL 283 Query: 296 IGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEA 355 I + G++T + + + + L +P++ +L + L L+ Sbjct: 284 ISLLLLGGLDTVVNFLSFFMIHLARHPELVAELRSDP-----------------LKLMRG 326 Query: 356 TIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPE 415 E+ R PV D + +G +++ ++ +P + Sbjct: 327 A-EEMFRRFPVVS--EARMVAKDQEYKGVFLKRGDMILLPTALHGLDDAANPEPWKLDFS 383 Query: 416 RFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF 463 R S+S+ FG GP C G LAR E+ + + L+R Sbjct: 384 R-----------RSISHSTFGGGPHRCAGMHLARMEVIVTLEEWLKRI 420 >4C9K-A nrPDB Length = 421 Score = 84.8 bits (208), Expect = 7e-17, Method: Composition-based stats. Identities = 41/297 (13%), Positives = 95/297 (31%), Gaps = 46/297 (15%) Query: 184 FNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLL 243 F + + P + + D L + + + N E+ +S Sbjct: 152 FGSEFSTVFPVRVFLALAGLPVEDATKLGLLANEMT--RPSGNTPEEQGRSLEAANKGFF 209 Query: 244 NKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAG 303 + R S T+++ ++ ++ D + + D+ L + + G Sbjct: 210 EY-VAPIIAARRGGSGTDLITRILNVEI-----------DGKPMPDDRALGLVSLLLLGG 257 Query: 304 VETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRL 363 ++T + + + + +L +P+ ++ E + L+ + E+ R Sbjct: 258 LDTVVNFLGFMMIYLSRHPETVAEMRREPLK------------------LQRGVEELFRR 299 Query: 364 RPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGT 423 A + D + +G +++ +++ P R Sbjct: 300 --FAVVSDARYVVSDMEFHGTMLKEGDLILLPTALHGLDDRHHDDPMTVDLSR------- 350 Query: 424 QLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRF-DLEVPDDGQLPSLEGI 479 V++ F GP C G LAR E+ +++ L R + + D GI Sbjct: 351 ----RDVTHSTFAQGPHRCAGMHLARLEVTVMLQEWLARIPEFRLKDRAVPIYHSGI 403 >2RCM-A nrPDB Length = 495 Score = 81.7 bits (200), Expect = 6e-16, Method: Composition-based stats. Identities = 34/156 (21%), Positives = 61/156 (39%), Gaps = 19/156 (12%) Query: 323 QVKKKLYEEIDQNVGFSR-TPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSI 381 QV +L EEI + + T+ ++ L ++ + E LR P A D I Sbjct: 316 QVHNRLAEEIRSVIKSNGGELTMGAIEKMELTKSVVYECLRFEPPVTAQYGR-AKKDLVI 374 Query: 382 GE----FAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGA 437 F V G + + K + + D+F+PERF+ G +L+ ++ + Sbjct: 375 ESHDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEEGEKLL----RHVLWSN 430 Query: 438 GP---------RSCIGEILARQELFLIMAWLLQRFD 464 GP + C G+ L + + +R+D Sbjct: 431 GPETETPTVGNKQCAGKDFVVLVARLFVIEIFRRYD 466 >3DBM-A nrPDB Length = 473 Score = 72.1 bits (175), Expect = 5e-13, Method: Composition-based stats. Identities = 70/480 (14%), Positives = 154/480 (32%), Gaps = 71/480 (14%) Query: 21 RCPGAKYPKSLLSLPLVGSL---PFLPRHGHMHNNFFKLQ-KKY-GPIYSVRMGTKT--- 72 + +P + + +F+ + +KY ++ M Sbjct: 4 SSKPLREIPGSYGIPFFQPIKDRLEYFYGTGGRDEYFRSRMQKYQSTVFRANMPPGPFVS 63 Query: 73 ----TVIVGHHQLAKEVL----IKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLH 124 +++ + + ++K F+G + + +++ D H Sbjct: 64 SNPKVIVLLDAKSFPILFDVSKVEKKDLFTG--TYMPSTKLTGGYRVLSYLDPSEP--RH 119 Query: 125 RRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICF 184 +L F + K+ ++ + L + L ++ F V + Sbjct: 120 AQLKNLLFFMLKNSSNRVIPQFETTYTELFEGLEAELAKN---GKAAFNDVGEQAAFRFL 176 Query: 185 NTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLV----PWLKIFPNKTLEKLKSHVKIRN 240 +Y N +PE + +I + +L + PW P +L + + Sbjct: 177 GRAYFNSNPEETKLGTSAPTLISSWVLFNLAPTLDLGLPWFLQEPLLHTFRLPAFL---- 232 Query: 241 DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF 300 K + + + ++ M P ++ ++IL + Sbjct: 233 -----------IKSTYNKLYDYFQSVATPVMEQAEKLGVPKDEAV----HNILFAVCFNT 277 Query: 301 GAGVETT-TSVVKWTLAFLLHNPQVKKKLYEEIDQNVGF--SRTPTISDRNRLLLLEATI 357 GV+ + +KW N + L EEI + T+ ++ L ++ + Sbjct: 278 FGGVKILFPNTLKWIGLA-GENLHTQ--LAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVV 334 Query: 358 REVLRLRPVAPMLIPHKANVDSSIGE----FAVDKGTEVIINLWALHHNEKEWHQPDQFM 413 E LR+ P P KA + +I F V KG + + K + +P++++ Sbjct: 335 YESLRIEPPVPPQYG-KAKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYV 393 Query: 414 PERFLNPAGTQLISPSVSYLPFGAGP---------RSCIGEILARQELFLIMAWLLQRFD 464 P+RF+ L Y+ + GP + C G+ L + L +R+D Sbjct: 394 PDRFVGDGEALL-----KYVWWSNGPETESPTVENKQCAGKDFVVLITRLFVIELFRRYD 448 >2YJN-B nrPDB Length = 381 Score = 58.6 bits (140), Expect = 7e-09, Method: Composition-based stats. Identities = 27/133 (20%), Positives = 55/133 (41%), Gaps = 22/133 (16%) Query: 300 FGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIRE 359 AG E T + V + + P + +++ ++ + T+ E Sbjct: 220 LFAGAEMTANTVVDAVLAVSAEPGLAERIADDPAAA------------------QRTVAE 261 Query: 360 VLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLN 419 VLRL P A L A + +GE + +G EV++ + A + + + + +PD+ +R Sbjct: 262 VLRLHP-ALHLERRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVDR--- 317 Query: 420 PAGTQLISPSVSY 432 P + +S + Sbjct: 318 PDADRALSAHRGH 330 >4YXC-B nrPDB Length = 227 Score = 34.7 bits (78), Expect = 0.096, Method: Composition-based stats. Identities = 25/140 (17%), Positives = 51/140 (36%), Gaps = 12/140 (8%) Query: 258 SITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAF 317 + ++++ ++ + N D+++ L D D TTT + Sbjct: 76 RVEHLINPILNSLNEEQPKNNPSDENTGALDD-----LWADALNEQKATTTKSAADAVFQ 130 Query: 318 LLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANV 377 L V + + ID + T+ L TI+E+LRL + + + A Sbjct: 131 QLGGGDVSGAMQD-IDLIMDIPVKLTVE----LGRTRMTIKELLRLTQGSVVALDGLAGE 185 Query: 378 --DSSIGEFAVDKGTEVIIN 395 D I + + +G V++ Sbjct: 186 PLDILINGYLIAQGEVVVVA 205 >4YXB-D nrPDB Length = 80 Score = 32.4 bits (72), Expect = 0.45, Method: Composition-based stats. Identities = 12/52 (23%), Positives = 23/52 (44%), Gaps = 2/52 (3%) Query: 346 DRNRLLLLEATIREVLRLRPVAPMLIPHKANV--DSSIGEFAVDKGTEVIIN 395 + L TI+E+LRL + + + A D I + + +G V++ Sbjct: 7 WADELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVVA 58 >2NYG-A nrPDB Length = 273 Score = 32.4 bits (72), Expect = 0.54, Method: Composition-based stats. Identities = 11/52 (21%), Positives = 23/52 (44%), Gaps = 2/52 (3%) Query: 383 EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLP 434 + ++GT V+ + + KEW P PE + + + + + +Y P Sbjct: 58 DVVTEEGTIVMPSQSVELSDPKEWGNPPV--PEEWWDIIRESMPAYNSNYTP 107 >4E22-A nrPDB Length = 252 Score = 29.7 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 13/72 (18%), Positives = 27/72 (37%), Gaps = 5/72 (6%) Query: 82 AKEVLIKKGKDFSGRPQMATL-----DIASNNRKGIAFADSGAHWQLHRRLAMATFALFK 136 +E L+++ + F P + I + F D+ + + HRR+ F Sbjct: 131 VREALLRRQRAFREAPGLIADGRDMGTIVFPDAPVKIFLDASSQERAHRRMLQLQERGFN 190 Query: 137 DGDQKLEKIICQ 148 ++L I + Sbjct: 191 VNFERLLAEIQE 202 >3RFT-A nrPDB Length = 267 Score = 28.9 bits (63), Expect = 5.5, Method: Composition-based stats. Identities = 13/57 (22%), Positives = 19/57 (33%), Gaps = 13/57 (22%) Query: 394 INLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQ 450 I + +H + Q ++ P+ P G G C GE LAR Sbjct: 106 IVFASSNHTIGYYPQTERLGPDVPARPDGL-------------YGVSKCFGENLARM 149 >2ZX8-A nrPDB Length = 455 Score = 28.6 bits (62), Expect = 6.4, Method: Composition-based stats. Identities = 12/65 (18%), Positives = 25/65 (38%) Query: 50 HNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNR 109 H+ F KY SV+ G K ++ + +E ++ G +SG Sbjct: 129 HDGFCLWGTKYTDFNSVKRGPKRDLVGDLAKAVREAGLRFGVYYSGGLDWRFTTEPIRYP 188 Query: 110 KGIAF 114 + +++ Sbjct: 189 EDLSY 193 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.128 0.335 Lambda K H 0.267 0.0395 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,342,768 Number of Sequences: 36641 Number of extensions: 736124 Number of successful extensions: 3148 Number of sequences better than 10.0: 177 Number of HSP's better than 10.0 without gapping: 273 Number of HSP's successfully gapped in prelim test: 69 Number of HSP's that attempted gapping in prelim test: 2179 Number of HSP's gapped (non-prelim): 363 length of query: 508 length of database: 10,336,785 effective HSP length: 101 effective length of query: 407 effective length of database: 6,636,044 effective search space: 2700869908 effective search space used: 2700869908 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 61 (28.2 bits)