BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P04807 (486 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1IG8-A nrPDB 1003 0.0 3B8A-X nrPDB 782 0.0 3O1W-A nrPDB 767 0.0 1BG3-A nrPDB 270 1e-72 4FOI-A nrPDB 265 3e-71 4QS9-A nrPDB 263 1e-70 3W0L-A nrPDB 260 7e-70 5ZQT-A nrPDB 259 2e-69 5HFU-A nrPDB 258 5e-69 3HM8-A nrPDB 255 2e-68 4DCH-A nrPDB 239 2e-63 1BDG-A nrPDB 230 1e-60 2YHX-A nrPDB 227 9e-60 1HKG-A nrPDB 222 2e-58 2ITM-A nrPDB 32 0.48 1C01-A nrPDB 32 0.69 4JE0-A nrPDB 30 1.9 6MSK-b nrPDB 30 3.1 5DJW-A nrPDB 29 4.2 4JDZ-A nrPDB 29 4.2 4MAD-A nrPDB 29 5.1 4E1J-A nrPDB 28 6.4 4R8E-A nrPDB 28 7.5 3AAG-A nrPDB 28 8.8 >1IG8-A nrPDB Length = 486 Score = 1003 bits (2593), Expect = 0.0, Method: Compositional matrix adjust. Identities = 486/486 (100%), Positives = 486/486 (100%) Query: 1 MVHLGPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKG 60 MVHLGPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKG Sbjct: 1 MVHLGPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKG 60 Query: 61 GNIPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRT 120 GNIPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRT Sbjct: 61 GNIPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRT 120 Query: 121 TQNPDELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDI 180 TQNPDELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDI Sbjct: 121 TQNPDELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDI 180 Query: 181 PNIENHDVVPMLQKQITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAY 240 PNIENHDVVPMLQKQITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAY Sbjct: 181 PNIENHDVVPMLQKQITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAY 240 Query: 241 YDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQT 300 YDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQT Sbjct: 241 YDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQT 300 Query: 301 FEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLED 360 FEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLED Sbjct: 301 FEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLED 360 Query: 361 TDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGHIAADGSV 420 TDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGHIAADGSV Sbjct: 361 TDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGHIAADGSV 420 Query: 421 YNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAEGKS 480 YNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAEGKS Sbjct: 421 YNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAEGKS 480 Query: 481 VGIIGA 486 VGIIGA Sbjct: 481 VGIIGA 486 >3B8A-X nrPDB Length = 485 Score = 782 bits (2020), Expect = 0.0, Method: Compositional matrix adjust. Identities = 376/486 (77%), Positives = 433/486 (89%), Gaps = 1/486 (0%) Query: 1 MVHLGPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKG 60 MVHLGPKKPQARKGSMADVPKELM +I E +FTV +ETL+ V KHFI EL KGL+KKG Sbjct: 1 MVHLGPKKPQARKGSMADVPKELMDEIHQLEDMFTVDSETLRKVVKHFIDELNKGLTKKG 60 Query: 61 GNIPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRT 120 GNIPMIPGWVM+FPTGKESG++LAIDLGGTNLRVVLVKL G+ TFDTTQSKY+LP MRT Sbjct: 61 GNIPMIPGWVMEFPTGKESGNYLAIDLGGTNLRVVLVKLSGNHTFDTTQSKYKLPHDMRT 120 Query: 121 TQNPDELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDI 180 T++ +ELW FIADSLK F+ EQ + +PLGFTFS+PASQNKINEGILQRWTKGFDI Sbjct: 121 TKHQEELWSFIADSLKDFMVEQELLNTKDTLPLGFTFSYPASQNKINEGILQRWTKGFDI 180 Query: 181 PNIENHDVVPMLQKQITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAY 240 PN+E HDVVP+LQ +I+KR +PIE+VALINDT GTL+ASYYTDPETKMGVIFGTGVNGA+ Sbjct: 181 PNVEGHDVVPLLQNEISKRELPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGAF 240 Query: 241 YDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQT 300 YDV SDIEKL+GKL+DDIP ++PMAINCEYGSFDNEH+VLPRTKYD+ +DE+SPRPGQQ Sbjct: 241 YDVVSDIEKLEGKLADDIPSNSPMAINCEYGSFDNEHLVLPRTKYDVAVDEQSPRPGQQA 300 Query: 301 FEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLED 360 FEKM+SGYYLGE+LRL L+++ ++G + K+QDLSK +P++MDTSYPARIE+DPFENLED Sbjct: 301 FEKMTSGYYLGELLRLVLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLED 360 Query: 361 TDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGHIAADGSV 420 TDD+FQ +FG+ TT+ ERKLIRRL ELIG RAARL+VCGIAAICQKRGYKTGHIAADGSV Sbjct: 361 TDDIFQKDFGVKTTLPERKLIRRLCELIGTRAARLAVCGIAAICQKRGYKTGHIAADGSV 420 Query: 421 YNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAEGKS 480 YN+YPGFKE AA L+DIYGWT + D PI IVPAEDGSGAGAAVIAAL++KRIAEGKS Sbjct: 421 YNKYPGFKEAAAKGLRDIYGWTGDASKD-PITIVPAEDGSGAGAAVIAALSEKRIAEGKS 479 Query: 481 VGIIGA 486 +GIIGA Sbjct: 480 LGIIGA 485 >3O1W-A nrPDB Length = 485 Score = 767 bits (1981), Expect = 0.0, Method: Compositional matrix adjust. Identities = 356/485 (73%), Positives = 417/485 (85%), Gaps = 1/485 (0%) Query: 1 MVHLGPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKG 60 MV LGPKKP ARKGSMADVP LM+QI E +FTV +E ++++ KHFISEL+KGLSKKG Sbjct: 1 MVRLGPKKPPARKGSMADVPANLMEQIHGLETLFTVSSEKMRSIVKHFISELDKGLSKKG 60 Query: 61 GNIPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRT 120 GNIPMIPGWV+++PTGKE+GDFLA+DLGGTNLRVVLVKLGG+ FDTTQ+KYRLPD +RT Sbjct: 61 GNIPMIPGWVVEYPTGKETGDFLALDLGGTNLRVVLVKLGGNHDFDTTQNKYRLPDHLRT 120 Query: 121 TQNPDELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDI 180 + ++LW FIA LK F+DE +P G+SEP+PLGFTFS+PASQ KIN G+LQRWTKGFDI Sbjct: 121 GTS-EQLWSFIAKCLKEFVDEWYPDGVSEPLPLGFTFSYPASQKKINSGVLQRWTKGFDI 179 Query: 181 PNIENHDVVPMLQKQITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAY 240 +E HDVVPMLQ+QI K NIPI VVALINDTTGTLVAS YTDP+TKMG+I GTGVNGAY Sbjct: 180 EGVEGHDVVPMLQEQIEKLNIPINVVALINDTTGTLVASLYTDPQTKMGIIIGTGVNGAY 239 Query: 241 YDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQT 300 YDV S IEKL+G L +DI P +PMAINCEYGSFDNEH+VLPRTKYD+ IDEESPRPGQQ Sbjct: 240 YDVVSGIEKLEGLLPEDIGPDSPMAINCEYGSFDNEHLVLPRTKYDVIIDEESPRPGQQA 299 Query: 301 FEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLED 360 FEKM+SGYYLGEI+RL L+D+Y GFIFK+QD+SK + +VMDTSYP++IE+DPFENLED Sbjct: 300 FEKMTSGYYLGEIMRLVLLDLYDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFENLED 359 Query: 361 TDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGHIAADGSV 420 TDDLF+ I TTV ERKLIR+L+EL+G RAARL+VCG++AIC KRGYKT HIAADGSV Sbjct: 360 TDDLFKTNLNIETTVVERKLIRKLAELVGTRAARLTVCGVSAICDKRGYKTAHIAADGSV 419 Query: 421 YNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAEGKS 480 +NRYPG+KEKAA ALKDIY W ++D+PI++V AEDGSG GAA+IA L QKR+A GKS Sbjct: 420 FNRYPGYKEKAAQALKDIYNWDVEKMEDHPIQLVAAEDGSGVGAAIIACLTQKRLAAGKS 479 Query: 481 VGIIG 485 VGI G Sbjct: 480 VGIKG 484 >1BG3-A nrPDB Length = 918 Score = 270 bits (689), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 172/484 (35%), Positives = 260/484 (53%), Gaps = 36/484 (7%) Query: 5 GPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGN-- 62 G K A ++A E +QIE F + +TL V K +E+E GL K+ + Sbjct: 448 GTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKA 507 Query: 63 -IPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKL--GGDRTFDTTQSKYRLP-DAM 118 + M+P +V P G E GDFLA+DLGGTN RV+LVK+ G RT + Y +P + M Sbjct: 508 TVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIM 567 Query: 119 RTTQNPDELWEFIADSLKAFIDEQFPQGISEP-IPLGFTFSFPASQNKINEGILQRWTKG 177 + T DEL++ I + F+D GI P +PLGFTFSFP Q ++ GIL WTKG Sbjct: 568 QGT--GDELFDHIVSCISDFLD---YMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKG 622 Query: 178 FDIPNIENHDVVPMLQKQITKRN-IPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGV 236 F + E HDV +L+ + +R ++VVA++NDT GT++ Y +P ++G+I GTG Sbjct: 623 FKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGT 682 Query: 237 NGAYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPR 295 N Y + ++E ++G M IN E+G+F DN + RT +D +DE S Sbjct: 683 NACYMEEMKNVEMVEGN-------QGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLN 735 Query: 296 PGQQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPF 355 G+Q FEKM SG YLGEI+R L+D K+GF+F+ Q + +T + ++IE D Sbjct: 736 SGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRL 795 Query: 356 ENLEDTDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQK----RG--Y 409 L+ L Q G+N+T + L++ + ++ RAA+L G+AA+ +K RG + Sbjct: 796 ALLQVRAILQQ--LGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDH 853 Query: 410 KTGHIAADGSVYNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAA 469 + DG++Y +P F +K++ S + +EDGSG GAA+I A Sbjct: 854 LNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSF-------LLSEDGSGKGAALITA 906 Query: 470 LAQK 473 + + Sbjct: 907 VGVR 910 Score = 217 bits (552), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 137/467 (29%), Positives = 250/467 (53%), Gaps = 33/467 (7%) Query: 24 MQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKK---GGNIPMIPGWVMDFPTGKESG 80 +++I+ + + E L + F E++ GLS+ ++ M+P +V P G E G Sbjct: 19 VKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKG 78 Query: 81 DFLAIDLGGTNLRVVLVKLGGDRTFDTTQSK--YRLPDAMRTTQNPDELWEFIADSLKAF 138 DF+A+DLGG++ R++ V++ ++ + + Y P+ + + +L++ +AD L F Sbjct: 79 DFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENI-VHGSGTQLFDHVADCLGDF 137 Query: 139 IDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITK 198 ++++ + + +P+GFTFSFP Q+KI+E +L WTK F +E DVV +L K I K Sbjct: 138 MEKKKIK--DKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKK 195 Query: 199 R-NIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDD 257 R + +VA++NDT GT++ Y D + ++G+I GTG N Y + I+ ++G Sbjct: 196 RGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEG----- 250 Query: 258 IPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRL 316 M IN E+G+F D+ + RT++D +D S PG+Q FEKM SG Y+GE++RL Sbjct: 251 --DEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRL 308 Query: 317 ALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTVQ 376 L+ M K+G +F+ + + +TS + IE+D E +++ ++ G+ + Sbjct: 309 ILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDK-EGIQNAKEIL-TRLGVEPSDV 366 Query: 377 ERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGH------IAADGSVYNRYPGFKEK 430 + ++ + ++ R+A L + AI + G + DGS+Y +P + + Sbjct: 367 DCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRR 426 Query: 431 AANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAE 477 L+ + + D ++ + +E G+G GAA++ A+A R+AE Sbjct: 427 FHKTLRRL-------VPDSDVRFLLSESGTGKGAAMVTAVAY-RLAE 465 >4FOI-A nrPDB Length = 917 Score = 265 bits (677), Expect = 3e-71, Method: Compositional matrix adjust. Identities = 174/491 (35%), Positives = 261/491 (53%), Gaps = 36/491 (7%) Query: 5 GPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGN-- 62 G K A ++A E +QIE F + + L V K +E+E GL K+ N Sbjct: 448 GSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNA 507 Query: 63 -IPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKL--GGDRTFDTTQSKYRLP-DAM 118 + M+P +V P G E+GDFLA+DLGGTN RV+LVK+ G RT + Y +P + M Sbjct: 508 VVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIM 567 Query: 119 RTTQNPDELWEFIADSLKAFIDEQFPQGISEP-IPLGFTFSFPASQNKINEGILQRWTKG 177 + T +EL++ I + F+D GI P +PLGFTFSFP Q ++ GIL WTKG Sbjct: 568 QGT--GEELFDHIVSCISDFLD---YMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKG 622 Query: 178 FDIPNIENHDVVPMLQKQITKRN-IPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGV 236 F + HDVV +L+ I +R ++VVA++NDT GT++ Y +P ++G+I GTG Sbjct: 623 FKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGS 682 Query: 237 NGAYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPR 295 N Y + ++E ++G M IN E+G+F DN + RT YD +DE S Sbjct: 683 NACYMEEMKNVEMVEG-------DQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLN 735 Query: 296 PGQQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPF 355 G+Q +EKM SG YLGEI+R L+D K+GF+F+ Q + +T + ++IE D Sbjct: 736 AGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRL 795 Query: 356 ENLEDTDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQK----RGYKT 411 L+ L Q G+N+T + L++ + ++ RAA+L G+AA+ K RG Sbjct: 796 ALLQVRAILQQ--LGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDR 853 Query: 412 GH--IAADGSVYNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAA 469 + + DG++Y +P F +K++ S + +EDGSG GAA+I A Sbjct: 854 LNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSF-------LLSEDGSGKGAALITA 906 Query: 470 LAQKRIAEGKS 480 + + E S Sbjct: 907 VGVRLRTEASS 917 Score = 219 bits (558), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 140/467 (29%), Positives = 247/467 (52%), Gaps = 33/467 (7%) Query: 24 MQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKK---GGNIPMIPGWVMDFPTGKESG 80 +++I+ + + ETL + F E++ GLS+ + M+P +V P G E G Sbjct: 19 VKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKG 78 Query: 81 DFLAIDLGGTNLRVVLVKLGGDRTFDTTQSK--YRLPDAMRTTQNPDELWEFIADSLKAF 138 DF+A+DLGG++ R++ V++ ++ + Y P+ + + +L++ +A+ L F Sbjct: 79 DFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENI-VHGSGSQLFDHVAECLGDF 137 Query: 139 IDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITK 198 ++++ + + +P+GFTFSFP Q+KI+E IL WTK F +E DVV +L K I K Sbjct: 138 MEKRKIK--DKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKK 195 Query: 199 R-NIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDD 257 R + +VA++NDT GT++ Y D ++G+I GTG N Y + I+ ++G Sbjct: 196 RGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEG----- 250 Query: 258 IPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRL 316 M IN E+G+F D+ + RT++D ID S PG+Q FEKM SG YLGE++RL Sbjct: 251 --DEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRL 308 Query: 317 ALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTVQ 376 L+ M K+G +F+ + + +TS + IE++ E L + ++ G+ + Sbjct: 309 ILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNK-EGLHNAKEIL-TRLGVEPSDD 366 Query: 377 ERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGH------IAADGSVYNRYPGFKEK 430 + ++ + ++ R+A L + AI + G + +GS+Y +P + + Sbjct: 367 DCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVNGSLYKTHPQYSRR 426 Query: 431 AANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAE 477 L+ + + D ++ + +E GSG GAA++ A+A R+AE Sbjct: 427 FHKTLRRL-------VPDSDVRFLLSESGSGKGAAMVTAVAY-RLAE 465 >4QS9-A nrPDB Length = 474 Score = 263 bits (672), Expect = 1e-70, Method: Compositional matrix adjust. Identities = 164/460 (35%), Positives = 241/460 (52%), Gaps = 30/460 (6%) Query: 27 IENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGN-IPMIPGWVMDFPTGKESGDFLAI 85 ++ FE+ P L+ V E+ GL+ GG+ + M+ +V + P+G E G F A+ Sbjct: 19 LKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKGLFYAL 78 Query: 86 DLGGTNLRVVLVKLGG--DRTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLKAFI---- 139 DLGGTN RV+ V LGG +R + +P + T DEL+ FIA++L F+ Sbjct: 79 DLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHL-MTGGSDELFNFIAEALAKFVATEC 137 Query: 140 -DEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITK 198 D P+G LGFTF+FP Q ++ G L +WTKGF I DVV L K + + Sbjct: 138 EDFHLPEGRQRE--LGFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALER 195 Query: 199 RNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDDI 258 + + + AL+NDT GTL Y +P+ VI GTG N AY + + I K G L Sbjct: 196 VGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLL---- 251 Query: 259 PPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLAL 318 P S M IN E+G+F + H LP T++D T+D ES PG+Q EK+ SG YLGEILR L Sbjct: 252 PKSGEMVINMEWGNFRSSH--LPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVL 309 Query: 319 MDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTT-VQE 377 + M + F + SK PF++ T + + + D +L+ ++ + TT ++ Sbjct: 310 LKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKM 369 Query: 378 RKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGH--------IAADGSVYNRYPGFKE 429 RK++ L +I R ARLS GI I +K G T IA DG ++ Y F E Sbjct: 370 RKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSE 429 Query: 430 KAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAA 469 ++LK++ G + +++ + DGSG GAA++AA Sbjct: 430 CMESSLKELLGDEASG----SVEVTHSNDGSGIGAALLAA 465 >3W0L-A nrPDB Length = 458 Score = 260 bits (665), Expect = 7e-70, Method: Compositional matrix adjust. Identities = 159/457 (34%), Positives = 250/457 (54%), Gaps = 38/457 (8%) Query: 34 FTVPTETLQAVTKHFISELEKGL---SKKGGNIPMIPGWVMDFPTGKESGDFLAIDLGGT 90 F + E L + +E+E+GL + + ++ M+P +V P G E GDFLA+DLGGT Sbjct: 16 FHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSEVGDFLALDLGGT 75 Query: 91 NLRVVLVKLG----GDRTFDTTQSKYRLP-DAMRTTQNPDELWEFIADSLKAFIDEQFPQ 145 N RV+LVK+G G +T Y +P DAM T + L+++IA+ + ++D+Q + Sbjct: 76 NFRVMLVKVGEDLEGQWKVETKHKMYSIPVDAM--TGTAEMLFDYIAECISDYLDQQNMK 133 Query: 146 GISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITKR-NIPIE 204 + +PLGFTFSFP I++GIL WTKGF E ++VV +L+ I +R + ++ Sbjct: 134 --HKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMD 191 Query: 205 VVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDDIPPSAPM 264 VVA++NDT T+++ YY D ++G+I GTG N Y + S++E ++G+ M Sbjct: 192 VVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGE-------EGRM 244 Query: 265 AINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLALMDMYK 323 +N E+G+F D + R +YD +DE S PGQQ +EKM G Y+GE++RL L+ M Sbjct: 245 CVNTEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGELVRLVLIKMVN 304 Query: 324 QGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTVQERKLIRR 383 + +F + K +T + ++IE D + + T ++ + G+ T+ + +R Sbjct: 305 ENLLFGGESSEKLKTRGAFETQFVSQIEADT-SDFKQTLNILRT-LGVQATIGDCHAVRL 362 Query: 384 LSELIGARAARLSVCGIAAIC----QKRGYKTGHI--AADGSVYNRYPGFKEK-AANALK 436 E + RAA + G+A I Q R + I DGSVY +P FK+K A LK Sbjct: 363 ACESVSTRAAIMCSAGLAGILNRMRQSRREELLRITVGVDGSVYKLHPSFKDKFHATVLK 422 Query: 437 DIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQK 473 G I + +E+GSG GAA+I+A+A K Sbjct: 423 LTSGC--------EITFIQSEEGSGRGAALISAVAYK 451 >5ZQT-A nrPDB Length = 473 Score = 259 bits (662), Expect = 2e-69, Method: Compositional matrix adjust. Identities = 163/463 (35%), Positives = 241/463 (52%), Gaps = 34/463 (7%) Query: 27 IENFEKIFTVPTETLQAVTKHFISELEKGL-SKKGGNIPMIPGWVMDFPTGKESGDFLAI 85 IE E+ F+ PT L+ + + E+E+GL + + M+ +V + PTG E G F A+ Sbjct: 16 IEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFYAL 75 Query: 86 DLGGTNLRVVLVKLGGDRTFDTTQSKYRL---PDAMRTTQNPDELWEFIADSLKAFI--- 139 DLGGTN RV+ V+LGG +Q + P M T EL++FIA L++F+ Sbjct: 76 DLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSM--ELFDFIAAELESFVKTE 133 Query: 140 --DEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQIT 197 D P+G LGFTFSFP Q I+ G L +WTKGF I DVV L + + Sbjct: 134 GEDFHLPEGRQRE--LGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME 191 Query: 198 KRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDD 257 ++ + ++V AL+NDT GTL Y D + VI GTG N AY + + I K G L Sbjct: 192 RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLL--- 248 Query: 258 IPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLA 317 P S M IN E+G+F +E LPR+ YD +D ES PG+Q +EKM SG YLGEI+R Sbjct: 249 -PRSGNMVINMEWGNFKSER--LPRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRI 305 Query: 318 LMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGI-NTTVQ 376 L+ + +F + +K ++ F++ T + + D +L+ ++ G+ +T+++ Sbjct: 306 LLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLE 365 Query: 377 ERKLIRRLSELIGARAARLSVCGIAAICQKRGY----------KTGHIAADGSVYNRYPG 426 R + + +L+ R ARL+ GI I +K G + IA DG +Y Y Sbjct: 366 ARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKK 425 Query: 427 FKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAA 469 F+ L D+ G S + + A DGSG GAA++AA Sbjct: 426 FRTCLEATLADLLGEEAAS----SVVVKLANDGSGIGAALLAA 464 >5HFU-A nrPDB Length = 923 Score = 258 bits (658), Expect = 5e-69, Method: Compositional matrix adjust. Identities = 156/472 (33%), Positives = 259/472 (54%), Gaps = 38/472 (8%) Query: 16 MADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKK---GGNIPMIPGWVMD 72 +AD + + +E+ + + + L V + E+E+GLSK+ + M+P +V Sbjct: 469 LADQHRARQKTLEHLQ----LSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCA 524 Query: 73 FPTGKESGDFLAIDLGGTNLRVVLVKLGGDR--TFDTTQSKYRLP-DAMRTTQNPDELWE 129 P G E GDFLA+DLGGTN RV+LV++ + + Y +P + M T DEL++ Sbjct: 525 TPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGT--GDELFD 582 Query: 130 FIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVV 189 I + F++ +G+S +PLGFTFSFP QN ++E IL +WTKGF E DVV Sbjct: 583 HIVQCIADFLEYMGMKGVS--LPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVV 640 Query: 190 PMLQKQITKRN-IPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIE 248 +L++ I +R ++VVA++NDT GT++ + DP ++G+I GTG N Y + ++E Sbjct: 641 TLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVE 700 Query: 249 KLQGKLSDDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSG 307 ++G+ M +N E+G+F DN + RT++D+ +DE S PG+Q FEKM SG Sbjct: 701 LVEGE-------EGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISG 753 Query: 308 YYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQN 367 YLGEI+R L+D K+G +F+ + + + +T + ++IE D L+ + Q+ Sbjct: 754 MYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQ-VRAILQH 812 Query: 368 EFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTG------HIAADGSVY 421 G+ +T + +++ + ++ RAA+L G+AA+ + G + DG++Y Sbjct: 813 -LGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLY 871 Query: 422 NRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQK 473 +P F + +KD+ S + +EDGSG GAA+I A+A + Sbjct: 872 KLHPHFAKVMHETVKDLAPKCDVSF-------LQSEDGSGKGAALITAVACR 916 Score = 241 bits (615), Expect = 5e-64, Method: Compositional matrix adjust. Identities = 155/470 (32%), Positives = 253/470 (53%), Gaps = 46/470 (9%) Query: 24 MQQIENFEKIFTVPTETLQAVTKHFISELEKGL---SKKGGNIPMIPGWVMDFPTGKESG 80 +Q+++ + + ETL ++K F E+EKGL + + M+P +V P G E G Sbjct: 25 VQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHG 84 Query: 81 DFLAIDLGGTNLRVVLVKL--GGDRTFDTTQSKYRLP-DAMRTTQNPDELWEFIADSLKA 137 +FLA+DLGGTN RV+ VK+ G + + Y +P D MR + +L++ IA+ L Sbjct: 85 EFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGT--QLFDHIAECLAN 142 Query: 138 FIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQIT 197 F+D+ Q + +PLGFTFSFP Q K++E L WTKGF +E DVV +++K I Sbjct: 143 FMDK--LQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQ 200 Query: 198 KR-NIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSD 256 +R + I++VA++NDT GT++ Y D ++G+I GTG N Y + I+ ++G Sbjct: 201 RRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG---- 256 Query: 257 DIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILR 315 M IN E+G+F D+ + RT++D ID S PG+Q FEKM SG Y+GE++R Sbjct: 257 ---DEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVR 313 Query: 316 LALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQN------EF 369 L L+ M K+ +F + LS P +++T R E ++E D + Sbjct: 314 LILVKMAKEELLFGGK-LS----PELLNT---GRFETKDISDIEGEKDGIRKAREVLMRL 365 Query: 370 GINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGH------IAADGSVYNR 423 G++ T ++ R+ +++ R+A L +AA+ Q+ G I DGSVY + Sbjct: 366 GLDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKK 425 Query: 424 YPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQK 473 +P F ++ ++ + + ++ + +EDGSG GAA++ A+A + Sbjct: 426 HPHFAKRLHKTVRRL-------VPGCDVRFLRSEDGSGKGAAMVTAVAYR 468 >3HM8-A nrPDB Length = 445 Score = 255 bits (652), Expect = 2e-68, Method: Compositional matrix adjust. Identities = 148/449 (32%), Positives = 245/449 (54%), Gaps = 31/449 (6%) Query: 34 FTVPTETLQAVTKHFISELEKGLSKKGGNIPMIPGWVMDFPTGKESGDFLAIDLGGTNLR 93 F + + L AV + KGL + ++ M+P +V P G E GDFLA+DLGGTN R Sbjct: 13 FRLNHDQLAAVQAQMRKAMAKGLRGEASSLRMLPTFVRATPDGSERGDFLALDLGGTNFR 72 Query: 94 VVLVKLGGDRTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLKAFIDEQFPQGIS-EPIP 152 V+LV++ T Y +P+ + + +L++ I D + +D Q QG+S + +P Sbjct: 73 VLLVRV--TTGVQITSEIYSIPETV-AQGSGQQLFDHIVDCI---VDFQQKQGLSGQSLP 126 Query: 153 LGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITKRN-IPIEVVALIND 211 LGFTFSFP Q +++GIL WTKGF + E DVV +L++ IT+R + + VVA++ND Sbjct: 127 LGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVND 186 Query: 212 TTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYG 271 T GT+++ Y DP ++G+I GTG N Y + ++ + G S M IN E+G Sbjct: 187 TVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGD-------SGRMCINMEWG 239 Query: 272 SF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLALMDMYKQGFIFKN 330 +F D+ + + T++D ++D+ S PG+Q FEKM SG YLGEI+R L+ + G +F+ Sbjct: 240 AFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRG 299 Query: 331 QDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTVQERKLIRRLSELIGA 390 Q + + + T + + IE D L + ++ G+ T + ++ + + + Sbjct: 300 QQIQRLQTRDIFKTKFLSEIESDSLA-LRQVRAILED-LGLPLTSDDALMVLEVCQAVSQ 357 Query: 391 RAARLSVCGIAAICQK----RGYK--TGHIAADGSVYNRYPGFKEKAANALKDIYGWTQT 444 RAA+L G+AA+ +K RG + + DG++Y +P F A ++++ Sbjct: 358 RAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELA----- 412 Query: 445 SLDDYPIKIVPAEDGSGAGAAVIAALAQK 473 + + +EDGSG GAA++ A+A + Sbjct: 413 --PRCVVTFLQSEDGSGKGAALVTAVACR 439 >4DCH-A nrPDB Length = 473 Score = 239 bits (610), Expect = 2e-63, Method: Compositional matrix adjust. Identities = 144/466 (30%), Positives = 253/466 (54%), Gaps = 36/466 (7%) Query: 25 QQIENFEKIFTVPTETLQAVTKHFISELEKGL---SKKGGNIPMIPGWVMDFPTGKESGD 81 +++E F + E L+ V + E+++GL + + ++ M+P +V P G E GD Sbjct: 14 EKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGD 73 Query: 82 FLAIDLGGTNLRVVLVKLG----GDRTFDTTQSKYRLP-DAMRTTQNPDELWEFIADSLK 136 FL++DLGGTN RV+LVK+G G + T Y +P DAM T + L+++I++ + Sbjct: 74 FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAM--TGTAEMLFDYISECIS 131 Query: 137 AFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQI 196 F+D+ Q + +PLGFTFSFP I++GIL WTKGF E ++VV +L+ I Sbjct: 132 DFLDKH--QMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAI 189 Query: 197 TKR-NIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLS 255 +R + ++VVA++NDT T+++ YY D + ++G+I GTG N Y + ++E ++G Sbjct: 190 KRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEG--- 246 Query: 256 DDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEIL 314 M +N E+G+F D+ + +YD +DE S PGQQ +EK+ G Y+GE++ Sbjct: 247 ----DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELV 302 Query: 315 RLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTT 374 RL L+ + + +F + + +T + +++E D + + + L + G+ + Sbjct: 303 RLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNIL--STLGLRPS 360 Query: 375 VQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGH------IAADGSVYNRYPGFK 428 + ++RR E + RAA + G+A + + + DGSVY +P FK Sbjct: 361 TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK 420 Query: 429 EKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKR 474 E+ +++ + + I + +E+GSG GAA+++A+A K+ Sbjct: 421 ERFHASVRRLTPSCE-------ITFIESEEGSGRGAALVSAVACKK 459 >1BDG-A nrPDB Length = 451 Score = 230 bits (586), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 141/459 (30%), Positives = 240/459 (52%), Gaps = 19/459 (4%) Query: 21 KELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSK---KGGNIPMIPGWVMDFPTGK 77 ++L +++ K F + + + + GL K + +I M P +V P G Sbjct: 6 QQLFEKVVEILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGT 65 Query: 78 ESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLKA 137 E+G+FLA+DLGGTN RV+ V L G Q + A + + + EL+++IA++L Sbjct: 66 ETGNFLALDLGGTNYRVLSVTLEGKGKSPRIQERTYCIPAEKMSGSGTELFKYIAETLAD 125 Query: 138 FIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQIT 197 F++ + + LGFTFSFP Q + L RWTKGF +E H+V +LQ ++ Sbjct: 126 FLENNGMK--DKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTELD 183 Query: 198 KRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDD 257 KR + ++ VA++NDT GTL + DP+ +G+I GTG N AY + S +E + G + Sbjct: 184 KRELNVKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDGVKEPE 243 Query: 258 IPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRL 316 + IN E+G+F + + RT++D ++D +S PG+Q +EKM SG YLGE++R Sbjct: 244 V------VINTEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRH 297 Query: 317 ALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTVQ 376 ++ + +Q +F+ + + T Y +E DP L +T + ++ + Sbjct: 298 IIVYLVEQKILFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEP 357 Query: 377 -ERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGHIAADGSVYNRYPGFKEKAANAL 435 + +++R E++ RAA L+ GIA I ++ + DGS+Y +P F E+ + Sbjct: 358 IDNRIVRYACEMVVKRAAYLAGAGIACILRRINRSEVTVGVDGSLYKFHPKFCER----M 413 Query: 436 KDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKR 474 D+ + + +++ +EDGSG GAA IAA ++ Sbjct: 414 TDMVDKLKPKNTRFCLRL--SEDGSGKGAAAIAASCTRQ 450 >2YHX-A nrPDB Length = 457 Score = 227 bits (579), Expect = 9e-60, Method: Compositional matrix adjust. Identities = 152/446 (34%), Positives = 210/446 (47%), Gaps = 10/446 (2%) Query: 27 IENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGNIPMIPGWVMDFPTGKESGDFLAID 86 +E +F VP LQAV ++ +IPM+PGWV+ +G ++G FLAI Sbjct: 9 VEVHXXVFIVPPXILQAVVS-ILTTRXDDXDSSAASIPMVPGWVLKQVSGAQAGSFLAIV 67 Query: 87 LGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLKAFIDEQFPQG 146 +GG +L V+L+ L G + S+ L AM TT P +LW A S A Sbjct: 68 MGGGDLEVILISLAGRQESSIXASR-SLAAAMSTTAIPSDLWGNXAXS-NAAFSSXEFSS 125 Query: 147 ISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITKRNIPIEVV 206 + +PLGFTF ++ + +G + F + + ++ + V Sbjct: 126 XAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAXLXK--LISAMXNAXFPAGDXXXSV 183 Query: 207 ALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDDIPPSAPMAI 266 A I D+ G L YTD KMG+IFG+GVN AY+ C + M I Sbjct: 184 ADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYW--CDSTXIGDAADGGXXGGAGXMXI 241 Query: 267 NCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLALMDMYKQGF 326 C+ SF LP+ Y T++ SP +TF K S G+ LR LM G Sbjct: 242 CCDQSSFRKAFPSLPQIXYLXTLNXXSPX-AXKTFXKNSXAKNXGQSLRDVLMXFKXXGQ 300 Query: 327 IFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTVQERKLIRRLSE 386 S F V +TSYPA+I++ P +L DLF + GI + ++RR Sbjct: 301 XHXXXAXS-FXAANVENTSYPAKIQKLPHFDLRXXXDLFXGDQGIAXKTXMKXVVRRXLF 359 Query: 387 LIGARAARLSVCGIAAICQKRGYKTGHIAADGSVYNRYPGFKEKAANALKDIYGWTQTSL 446 LI A A RL VC I AICQK+GY +GHIAA GS Y GF +A +IYGW Q++ Sbjct: 360 LIAAYAFRLVVCXIXAICQKKGYSSGHIAAXGSX-RSYSGFSXNSATXNXNIYGWPQSAX 418 Query: 447 DDYPIKIVPAEDGSGAGAAVIAALAQ 472 PI I PA DG GA + VI ++A Sbjct: 419 XSKPIXITPAIDGXGAASXVIXSIAS 444 >1HKG-A nrPDB Length = 457 Score = 222 bits (566), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 150/448 (33%), Positives = 210/448 (46%), Gaps = 10/448 (2%) Query: 27 IENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGNIPMIPGWVMDFPTGKESGDFLAID 86 +E +F VP LQAV + +IPM+PGWV+ G ++G FLAI Sbjct: 9 VEVHXXVFIVPPXILQAVVS-IATTRXDDXDSAAASIPMVPGWVLKQVXGSQAGSFLAIV 67 Query: 87 LGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLKAFIDEQFPQG 146 +GG +L V+L+ L G + S+ L +M TT P +LW A S A Sbjct: 68 MGGGDLEVILIXLAGYQESSIXASR-SLAASMXTTAIPSDLWGNXAXS-NAAFSSXEFSS 125 Query: 147 ISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITKRNIPIEVV 206 + +PLGFTF ++ + +G + F + + ++ + V Sbjct: 126 XAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAXLXK--LISAMXNAXFPAGDXXXXV 183 Query: 207 ALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDDIPPSAPMAI 266 A I D+ G L YTD KMG+IFG+GVN AY+ C + + M + Sbjct: 184 ADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYW--CDSTXIADAADAGXXGGAGXMXV 241 Query: 267 NCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLALMDMYKQGF 326 C SF LP+ Y T++ SP +TFEK S G+ LR LM YK Sbjct: 242 CCXQDSFRKAFPSLPQIXYXXTLNXXSPX-AXKTFEKNSXAKNXGQSLRDVLM-XYKXXG 299 Query: 327 IFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTVQERKLIRRLSE 386 F V ++SYPA+I++ P +L DLF + GI + ++RR Sbjct: 300 QXHXXXAXDFXAANVENSSYPAKIQKLPHFDLRXXXDLFXGDQGIAXKTXMKXVVRRXLF 359 Query: 387 LIGARAARLSVCGIAAICQKRGYKTGHIAADGSVYNRYPGFKEKAANALKDIYGWTQTSL 446 LI A A RL VC I AICQK+GY +GHIAA GS + Y GF +A +IYGW Q++ Sbjct: 360 LIAAYAFRLVVCXIXAICQKKGYSSGHIAAXGSXRD-YSGFSXNSATXNXNIYGWPQSAX 418 Query: 447 DDYPIKIVPAEDGSGAGAAVIAALAQKR 474 PI I PA DG GA VI ++A + Sbjct: 419 XSKPIXITPAIDGEGAAXXVIXSIASSQ 446 >2ITM-A nrPDB Length = 484 Score = 32.3 bits (72), Expect = 0.48, Method: Compositional matrix adjust. Identities = 16/67 (23%), Positives = 35/67 (52%), Gaps = 1/67 (1%) Query: 82 FLAIDLGGTNLRVVLVKLGGDRTFDTTQS-KYRLPDAMRTTQNPDELWEFIADSLKAFID 140 ++ IDLG + ++V+L+ G+ T+ P + + Q+P++ W+ ++KA D Sbjct: 2 YIGIDLGTSGVKVILLNEQGEVVAAQTEKLTVSRPHPLWSEQDPEQWWQATDRAMKALGD 61 Query: 141 EQFPQGI 147 + Q + Sbjct: 62 QHSLQDV 68 >1C01-A nrPDB Length = 76 Score = 32.0 bits (71), Expect = 0.69, Method: Composition-based stats. Identities = 14/33 (42%), Positives = 19/33 (57%) Query: 391 RAARLSVCGIAAICQKRGYKTGHIAADGSVYNR 423 RA R S CG +AI QK GY + ++YN+ Sbjct: 14 RAERYSKCGCSAIHQKGGYDFSYTGQTAALYNQ 46 >4JE0-A nrPDB Length = 316 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 18/55 (32%), Positives = 32/55 (58%), Gaps = 2/55 (3%) Query: 241 YDVCSD-IEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESP 294 YDV ++ + + + D I A ++N ++GS +N +VV+ TK++ T ESP Sbjct: 241 YDVNTNQLIDVTEQFKDKITYGANDSVNVDFGSINNSYVVMVDTKFEYTT-SESP 294 >6MSK-b nrPDB Length = 377 Score = 29.6 bits (65), Expect = 3.1, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 23/42 (54%), Gaps = 1/42 (2%) Query: 319 MDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLED 360 M M QG F + + D MDTS PA+ EED ++ ++D Sbjct: 291 MQMSLQGAEFGQAESADIDASSAMDTSEPAK-EEDDYDVMQD 331 >5DJW-A nrPDB Length = 697 Score = 29.3 bits (64), Expect = 4.2, Method: Compositional matrix adjust. Identities = 14/42 (33%), Positives = 23/42 (54%), Gaps = 8/42 (19%) Query: 32 KIFTVPTETLQAVTKHFISELEKGLSKKGGNIPMIPGWVMDF 73 ++F + E+ QAV + GLS+ G +PMIP W + + Sbjct: 145 RVFIIDRESPQAVIR--------GLSELTGTMPMIPRWALGY 178 >4JDZ-A nrPDB Length = 438 Score = 29.3 bits (64), Expect = 4.2, Method: Compositional matrix adjust. Identities = 15/49 (30%), Positives = 29/49 (59%), Gaps = 1/49 (2%) Query: 241 YDVCSD-IEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDIT 288 YDV ++ + + + D I A ++N ++GS +N +VV+ TK++ T Sbjct: 236 YDVNTNQLIDVTEQFKDKITYGANDSVNVDFGSINNSYVVMVDTKFEYT 284 >4MAD-A nrPDB Length = 600 Score = 28.9 bits (63), Expect = 5.1, Method: Compositional matrix adjust. Identities = 17/42 (40%), Positives = 23/42 (54%), Gaps = 2/42 (4%) Query: 239 AYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVL 280 AY+DV E+L+ LS + P + I EYGSF N+ L Sbjct: 143 AYFDVL--FERLRPLLSSNGGPIIALQIENEYGSFGNDQKYL 182 >4E1J-A nrPDB Length = 520 Score = 28.5 bits (62), Expect = 6.4, Method: Compositional matrix adjust. Identities = 16/64 (25%), Positives = 33/64 (51%), Gaps = 3/64 (4%) Query: 80 GDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYR--LPDAMRTTQNPDELWEFIADSLKA 137 G LAID G T+ R ++ G + Q +++ P + +P+E+W+ + ++K Sbjct: 26 GYILAIDQGTTSTRAIVFD-GNQKIAGVGQKEFKQHFPKSGWVEHDPEEIWQTVVSTVKE 84 Query: 138 FIDE 141 I++ Sbjct: 85 AIEK 88 >4R8E-A nrPDB Length = 413 Score = 28.5 bits (62), Expect = 7.5, Method: Compositional matrix adjust. Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 6/80 (7%) Query: 410 KTGHIAADGS---VYNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAV 466 + G + DG+ V Y K++ A ++ G+ +S D Y + P EDGSGA A+ Sbjct: 227 RDGFVLGDGAGMMVLEEYEHAKKRGAKIYAEVVGFGMSS-DAYHMT-SPPEDGSGAALAM 284 Query: 467 IAALAQKRIAEGKSVGIIGA 486 + AL I + +G I A Sbjct: 285 VNALRDAGITTSQ-IGYINA 303 >3AAG-A nrPDB Length = 291 Score = 28.1 bits (61), Expect = 8.8, Method: Compositional matrix adjust. Identities = 15/44 (34%), Positives = 21/44 (47%) Query: 309 YLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEE 352 YL R++L+ F F N D DKPF T+YP ++ Sbjct: 139 YLYMPARMSLIFSTVASFSFINLDTGVLDKPFTFSTAYPLDVKN 182 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1IG8-A nrPDB 730 0.0 3O1W-A nrPDB 694 0.0 3B8A-X nrPDB 681 0.0 4FOI-A nrPDB 613 e-176 1BG3-A nrPDB 607 e-174 5HFU-A nrPDB 595 e-170 3W0L-A nrPDB 551 e-157 1BDG-A nrPDB 545 e-155 4DCH-A nrPDB 541 e-154 3HM8-A nrPDB 539 e-153 5ZQT-A nrPDB 507 e-144 4QS9-A nrPDB 503 e-143 2YHX-A nrPDB 374 e-104 1HKG-A nrPDB 360 1e-99 Sequences not found previously or not previously below threshold: 4W8B-A nrPDB 32 0.82 2FEZ-A nrPDB 31 1.5 6MSK-b nrPDB 30 2.0 3BDK-A nrPDB 30 3.3 2ITM-A nrPDB 29 5.1 5KJW-A nrPDB 28 8.8 CONVERGED! >1IG8-A nrPDB Length = 486 Score = 730 bits (1885), Expect = 0.0, Method: Composition-based stats. Identities = 486/486 (100%), Positives = 486/486 (100%) Query: 1 MVHLGPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKG 60 MVHLGPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKG Sbjct: 1 MVHLGPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKG 60 Query: 61 GNIPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRT 120 GNIPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRT Sbjct: 61 GNIPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRT 120 Query: 121 TQNPDELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDI 180 TQNPDELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDI Sbjct: 121 TQNPDELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDI 180 Query: 181 PNIENHDVVPMLQKQITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAY 240 PNIENHDVVPMLQKQITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAY Sbjct: 181 PNIENHDVVPMLQKQITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAY 240 Query: 241 YDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQT 300 YDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQT Sbjct: 241 YDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQT 300 Query: 301 FEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLED 360 FEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLED Sbjct: 301 FEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLED 360 Query: 361 TDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGHIAADGSV 420 TDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGHIAADGSV Sbjct: 361 TDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGHIAADGSV 420 Query: 421 YNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAEGKS 480 YNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAEGKS Sbjct: 421 YNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAEGKS 480 Query: 481 VGIIGA 486 VGIIGA Sbjct: 481 VGIIGA 486 >3O1W-A nrPDB Length = 485 Score = 694 bits (1792), Expect = 0.0, Method: Composition-based stats. Identities = 356/485 (73%), Positives = 416/485 (85%), Gaps = 1/485 (0%) Query: 1 MVHLGPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKG 60 MV LGPKKP ARKGSMADVP LM+QI E +FTV +E ++++ KHFISEL+KGLSKKG Sbjct: 1 MVRLGPKKPPARKGSMADVPANLMEQIHGLETLFTVSSEKMRSIVKHFISELDKGLSKKG 60 Query: 61 GNIPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRT 120 GNIPMIPGWV+++PTGKE+GDFLA+DLGGTNLRVVLVKLGG+ FDTTQ+KYRLPD +R Sbjct: 61 GNIPMIPGWVVEYPTGKETGDFLALDLGGTNLRVVLVKLGGNHDFDTTQNKYRLPDHLR- 119 Query: 121 TQNPDELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDI 180 T ++LW FIA LK F+DE +P G+SEP+PLGFTFS+PASQ KIN G+LQRWTKGFDI Sbjct: 120 TGTSEQLWSFIAKCLKEFVDEWYPDGVSEPLPLGFTFSYPASQKKINSGVLQRWTKGFDI 179 Query: 181 PNIENHDVVPMLQKQITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAY 240 +E HDVVPMLQ+QI K NIPI VVALINDTTGTLVAS YTDP+TKMG+I GTGVNGAY Sbjct: 180 EGVEGHDVVPMLQEQIEKLNIPINVVALINDTTGTLVASLYTDPQTKMGIIIGTGVNGAY 239 Query: 241 YDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQT 300 YDV S IEKL+G L +DI P +PMAINCEYGSFDNEH+VLPRTKYD+ IDEESPRPGQQ Sbjct: 240 YDVVSGIEKLEGLLPEDIGPDSPMAINCEYGSFDNEHLVLPRTKYDVIIDEESPRPGQQA 299 Query: 301 FEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLED 360 FEKM+SGYYLGEI+RL L+D+Y GFIFK+QD+SK + +VMDTSYP++IE+DPFENLED Sbjct: 300 FEKMTSGYYLGEIMRLVLLDLYDSGFIFKDQDISKLKEAYVMDTSYPSKIEDDPFENLED 359 Query: 361 TDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGHIAADGSV 420 TDDLF+ I TTV ERKLIR+L+EL+G RAARL+VCG++AIC KRGYKT HIAADGSV Sbjct: 360 TDDLFKTNLNIETTVVERKLIRKLAELVGTRAARLTVCGVSAICDKRGYKTAHIAADGSV 419 Query: 421 YNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAEGKS 480 +NRYPG+KEKAA ALKDIY W ++D+PI++V AEDGSG GAA+IA L QKR+A GKS Sbjct: 420 FNRYPGYKEKAAQALKDIYNWDVEKMEDHPIQLVAAEDGSGVGAAIIACLTQKRLAAGKS 479 Query: 481 VGIIG 485 VGI G Sbjct: 480 VGIKG 484 >3B8A-X nrPDB Length = 485 Score = 681 bits (1757), Expect = 0.0, Method: Composition-based stats. Identities = 376/486 (77%), Positives = 433/486 (89%), Gaps = 1/486 (0%) Query: 1 MVHLGPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKG 60 MVHLGPKKPQARKGSMADVPKELM +I E +FTV +ETL+ V KHFI EL KGL+KKG Sbjct: 1 MVHLGPKKPQARKGSMADVPKELMDEIHQLEDMFTVDSETLRKVVKHFIDELNKGLTKKG 60 Query: 61 GNIPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRT 120 GNIPMIPGWVM+FPTGKESG++LAIDLGGTNLRVVLVKL G+ TFDTTQSKY+LP MRT Sbjct: 61 GNIPMIPGWVMEFPTGKESGNYLAIDLGGTNLRVVLVKLSGNHTFDTTQSKYKLPHDMRT 120 Query: 121 TQNPDELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDI 180 T++ +ELW FIADSLK F+ EQ + +PLGFTFS+PASQNKINEGILQRWTKGFDI Sbjct: 121 TKHQEELWSFIADSLKDFMVEQELLNTKDTLPLGFTFSYPASQNKINEGILQRWTKGFDI 180 Query: 181 PNIENHDVVPMLQKQITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAY 240 PN+E HDVVP+LQ +I+KR +PIE+VALINDT GTL+ASYYTDPETKMGVIFGTGVNGA+ Sbjct: 181 PNVEGHDVVPLLQNEISKRELPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGAF 240 Query: 241 YDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQT 300 YDV SDIEKL+GKL+DDIP ++PMAINCEYGSFDNEH+VLPRTKYD+ +DE+SPRPGQQ Sbjct: 241 YDVVSDIEKLEGKLADDIPSNSPMAINCEYGSFDNEHLVLPRTKYDVAVDEQSPRPGQQA 300 Query: 301 FEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLED 360 FEKM+SGYYLGE+LRL L+++ ++G + K+QDLSK +P++MDTSYPARIE+DPFENLED Sbjct: 301 FEKMTSGYYLGELLRLVLLELNEKGLMLKDQDLSKLKQPYIMDTSYPARIEDDPFENLED 360 Query: 361 TDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGHIAADGSV 420 TDD+FQ +FG+ TT+ ERKLIRRL ELIG RAARL+VCGIAAICQKRGYKTGHIAADGSV Sbjct: 361 TDDIFQKDFGVKTTLPERKLIRRLCELIGTRAARLAVCGIAAICQKRGYKTGHIAADGSV 420 Query: 421 YNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAEGKS 480 YN+YPGFKE AA L+DIYGWT + D PI IVPAEDGSGAGAAVIAAL++KRIAEGKS Sbjct: 421 YNKYPGFKEAAAKGLRDIYGWTGDASKD-PITIVPAEDGSGAGAAVIAALSEKRIAEGKS 479 Query: 481 VGIIGA 486 +GIIGA Sbjct: 480 LGIIGA 485 >4FOI-A nrPDB Length = 917 Score = 613 bits (1580), Expect = e-176, Method: Composition-based stats. Identities = 169/489 (34%), Positives = 254/489 (51%), Gaps = 32/489 (6%) Query: 5 GPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGN-- 62 G K A ++A E +QIE F + + L V K +E+E GL K+ N Sbjct: 448 GSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNA 507 Query: 63 -IPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKL--GGDRTFDTTQSKYRLPDAMR 119 + M+P +V P G E+GDFLA+DLGGTN RV+LVK+ G RT + Y +P Sbjct: 508 VVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIP-IEI 566 Query: 120 TTQNPDELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFD 179 +EL++ I + F+D +G +PLGFTFSFP Q ++ GIL WTKGF Sbjct: 567 MQGTGEELFDHIVSCISDFLDYMGIKGPR--MPLGFTFSFPCQQTSLDAGILITWTKGFK 624 Query: 180 IPNIENHDVVPMLQKQITKRN-IPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNG 238 + HDVV +L+ I +R ++VVA++NDT GT++ Y +P ++G+I GTG N Sbjct: 625 ATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNA 684 Query: 239 AYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPG 297 Y + ++E ++G M IN E+G+F DN + RT YD +DE S G Sbjct: 685 CYMEEMKNVEMVEG-------DQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAG 737 Query: 298 QQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFEN 357 +Q +EKM SG YLGEI+R L+D K+GF+F+ Q + +T + ++IE D Sbjct: 738 KQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLAL 797 Query: 358 LEDTDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTG----- 412 L+ L Q G+N+T + L++ + ++ RAA+L G+AA+ K G Sbjct: 798 LQVRAILQQ--LGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLN 855 Query: 413 -HIAADGSVYNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALA 471 + DG++Y +P F +K++ S + +EDGSG GAA+I A+ Sbjct: 856 VTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVS-------FLLSEDGSGKGAALITAVG 908 Query: 472 QKRIAEGKS 480 + E S Sbjct: 909 VRLRTEASS 917 Score = 451 bits (1161), Expect = e-127, Method: Composition-based stats. Identities = 136/473 (28%), Positives = 243/473 (51%), Gaps = 32/473 (6%) Query: 22 ELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLS---KKGGNIPMIPGWVMDFPTGKE 78 + +++I+ + + ETL + F E++ GLS + M+P +V P G E Sbjct: 17 DQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSE 76 Query: 79 SGDFLAIDLGGTNLRVVLVKL--GGDRTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLK 136 GDF+A+DLGG++ R++ V++ ++ Y P+ + + +L++ +A+ L Sbjct: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVH-GSGSQLFDHVAECLG 135 Query: 137 AFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQI 196 F++++ + + +P+GFTFSFP Q+KI+E IL WTK F +E DVV +L K I Sbjct: 136 DFMEKRKIK--DKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAI 193 Query: 197 TKRNI-PIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLS 255 KR +VA++NDT GT++ Y D ++G+I GTG N Y + I+ ++G Sbjct: 194 KKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEG--- 250 Query: 256 DDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEIL 314 M IN E+G+F D+ + RT++D ID S PG+Q FEKM SG YLGE++ Sbjct: 251 ----DEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELV 306 Query: 315 RLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTT 374 RL L+ M K+G +F+ + + +TS + IE++ E L + ++ G+ + Sbjct: 307 RLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNK-EGLHNAKEIL-TRLGVEPS 364 Query: 375 VQERKLIRRLSELIGARAARLSVCGIAAICQKRG------YKTGHIAADGSVYNRYPGFK 428 + ++ + ++ R+A L + AI + + +GS+Y +P + Sbjct: 365 DDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVNGSLYKTHPQYS 424 Query: 429 EKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAEGKSV 481 + L+ + D ++ + +E GSG GAA++ A+A + + + + Sbjct: 425 RRFHKTLRRLVP-------DSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQI 470 >1BG3-A nrPDB Length = 918 Score = 607 bits (1565), Expect = e-174, Method: Composition-based stats. Identities = 167/488 (34%), Positives = 254/488 (52%), Gaps = 32/488 (6%) Query: 5 GPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGN-- 62 G K A ++A E +QIE F + +TL V K +E+E GL K+ + Sbjct: 448 GTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKA 507 Query: 63 -IPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKL--GGDRTFDTTQSKYRLPDAMR 119 + M+P +V P G E GDFLA+DLGGTN RV+LVK+ G RT + Y +P Sbjct: 508 TVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIP-LEI 566 Query: 120 TTQNPDELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFD 179 DEL++ I + F+D +G +PLGFTFSFP Q ++ GIL WTKGF Sbjct: 567 MQGTGDELFDHIVSCISDFLDYMGIKGPR--MPLGFTFSFPCHQTNLDCGILISWTKGFK 624 Query: 180 IPNIENHDVVPMLQKQITKRN-IPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNG 238 + E HDV +L+ + +R ++VVA++NDT GT++ Y +P ++G+I GTG N Sbjct: 625 ATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNA 684 Query: 239 AYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPG 297 Y + ++E ++G M IN E+G+F DN + RT +D +DE S G Sbjct: 685 CYMEEMKNVEMVEGN-------QGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSG 737 Query: 298 QQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFEN 357 +Q FEKM SG YLGEI+R L+D K+GF+F+ Q + +T + ++IE D Sbjct: 738 KQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLAL 797 Query: 358 LEDTDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTG----- 412 L+ L Q G+N+T + L++ + ++ RAA+L G+AA+ +K G Sbjct: 798 LQVRAILQQ--LGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLN 855 Query: 413 -HIAADGSVYNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALA 471 + DG++Y +P F +K++ S + +EDGSG GAA+I A+ Sbjct: 856 VTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVS-------FLLSEDGSGKGAALITAVG 908 Query: 472 QKRIAEGK 479 + + Sbjct: 909 VRLRGDPS 916 Score = 447 bits (1151), Expect = e-126, Method: Composition-based stats. Identities = 133/473 (28%), Positives = 244/473 (51%), Gaps = 32/473 (6%) Query: 22 ELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLS---KKGGNIPMIPGWVMDFPTGKE 78 + +++I+ + + E L + F E++ GLS ++ M+P +V P G E Sbjct: 17 DQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSE 76 Query: 79 SGDFLAIDLGGTNLRVVLVKL--GGDRTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLK 136 GDF+A+DLGG++ R++ V++ ++ Y P+ + + +L++ +AD L Sbjct: 77 KGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVH-GSGTQLFDHVADCLG 135 Query: 137 AFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQI 196 F++++ + +P+GFTFSFP Q+KI+E +L WTK F +E DVV +L K I Sbjct: 136 DFMEKKKIKDKK--LPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAI 193 Query: 197 TKRNI-PIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLS 255 KR +VA++NDT GT++ Y D + ++G+I GTG N Y + I+ ++G Sbjct: 194 KKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEG--- 250 Query: 256 DDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEIL 314 M IN E+G+F D+ + RT++D +D S PG+Q FEKM SG Y+GE++ Sbjct: 251 ----DEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELV 306 Query: 315 RLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTT 374 RL L+ M K+G +F+ + + +TS + IE+D E +++ ++ G+ + Sbjct: 307 RLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDK-EGIQNAKEIL-TRLGVEPS 364 Query: 375 VQERKLIRRLSELIGARAARLSVCGIAAICQKRG------YKTGHIAADGSVYNRYPGFK 428 + ++ + ++ R+A L + AI + + DGS+Y +P + Sbjct: 365 DVDCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYS 424 Query: 429 EKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKRIAEGKSV 481 + L+ + D ++ + +E G+G GAA++ A+A + + + + Sbjct: 425 RRFHKTLRRLVP-------DSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQI 470 >5HFU-A nrPDB Length = 923 Score = 595 bits (1535), Expect = e-170, Method: Composition-based stats. Identities = 159/489 (32%), Positives = 260/489 (53%), Gaps = 34/489 (6%) Query: 5 GPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKG---G 61 G K A ++A + + + + + + L V + E+E+GLSK+ Sbjct: 454 GSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASA 513 Query: 62 NIPMIPGWVMDFPTGKESGDFLAIDLGGTNLRVVLVKLG-GDRT-FDTTQSKYRLP-DAM 118 + M+P +V P G E GDFLA+DLGGTN RV+LV++ G + Y +P + M Sbjct: 514 PVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVM 573 Query: 119 RTTQNPDELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGF 178 T DEL++ I + F++ +G+S +PLGFTFSFP QN ++E IL +WTKGF Sbjct: 574 HGTG--DELFDHIVQCIADFLEYMGMKGVS--LPLGFTFSFPCQQNSLDESILLKWTKGF 629 Query: 179 DIPNIENHDVVPMLQKQITKRN-IPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVN 237 E DVV +L++ I +R ++VVA++NDT GT++ + DP ++G+I GTG N Sbjct: 630 KASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSN 689 Query: 238 GAYYDVCSDIEKLQGKLSDDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRP 296 Y + ++E ++G+ M +N E+G+F DN + RT++D+ +DE S P Sbjct: 690 ACYMEEMRNVELVEGE-------EGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNP 742 Query: 297 GQQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFE 356 G+Q FEKM SG YLGEI+R L+D K+G +F+ + + + +T + ++IE D Sbjct: 743 GKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLA 802 Query: 357 NLEDTDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTG---- 412 L+ L G+ +T + +++ + ++ RAA+L G+AA+ + G Sbjct: 803 LLQVRAILQH--LGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDAL 860 Query: 413 --HIAADGSVYNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAAL 470 + DG++Y +P F + +KD+ S + +EDGSG GAA+I A+ Sbjct: 861 KVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVS-------FLQSEDGSGKGAALITAV 913 Query: 471 AQKRIAEGK 479 A + G+ Sbjct: 914 ACRIREAGQ 922 Score = 486 bits (1251), Expect = e-138, Method: Composition-based stats. Identities = 148/466 (31%), Positives = 248/466 (53%), Gaps = 32/466 (6%) Query: 21 KELMQQIENFEKIFTVPTETLQAVTKHFISELEKGL---SKKGGNIPMIPGWVMDFPTGK 77 + +Q+++ + + ETL ++K F E+EKGL + + M+P +V P G Sbjct: 22 SDQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGT 81 Query: 78 ESGDFLAIDLGGTNLRVVLVKL--GGDRTFDTTQSKYRLPDAMRTTQNPDELWEFIADSL 135 E G+FLA+DLGGTN RV+ VK+ G + + Y +P+ + + +L++ IA+ L Sbjct: 82 EHGEFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDI-MRGSGTQLFDHIAECL 140 Query: 136 KAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQ 195 F+D+ Q + +PLGFTFSFP Q K++E L WTKGF +E DVV +++K Sbjct: 141 ANFMDK--LQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKA 198 Query: 196 ITKRN-IPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKL 254 I +R I++VA++NDT GT++ Y D ++G+I GTG N Y + I+ ++G Sbjct: 199 IQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEG-- 256 Query: 255 SDDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEI 313 M IN E+G+F D+ + RT++D ID S PG+Q FEKM SG Y+GE+ Sbjct: 257 -----DEGRMCINMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGEL 311 Query: 314 LRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINT 373 +RL L+ M K+ +F + + +T + IE + + + L + G++ Sbjct: 312 VRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMR--LGLDP 369 Query: 374 TVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTG------HIAADGSVYNRYPGF 427 T ++ R+ +++ R+A L +AA+ Q+ G I DGSVY ++P F Sbjct: 370 TQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHF 429 Query: 428 KEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQK 473 ++ ++ + ++ + +EDGSG GAA++ A+A + Sbjct: 430 AKRLHKTVRRLVPGCD-------VRFLRSEDGSGKGAAMVTAVAYR 468 >3W0L-A nrPDB Length = 458 Score = 551 bits (1419), Expect = e-157, Method: Composition-based stats. Identities = 152/466 (32%), Positives = 249/466 (53%), Gaps = 36/466 (7%) Query: 24 MQQIENFEKIFTVPTETLQAVTKHFISELEKGL---SKKGGNIPMIPGWVMDFPTGKESG 80 +++ F + E L + +E+E+GL + + ++ M+P +V P G E G Sbjct: 6 QNEVDQILSEFHLQEEDLHVLMCRMQAEMERGLHLETNEEASVKMLPTYVRSTPDGSEVG 65 Query: 81 DFLAIDLGGTNLRVVLVKLG----GDRTFDTTQSKYRLP-DAMRTTQNPDELWEFIADSL 135 DFLA+DLGGTN RV+LVK+G G +T Y +P DAM T + L+++IA+ + Sbjct: 66 DFLALDLGGTNFRVMLVKVGEDLEGQWKVETKHKMYSIPVDAM--TGTAEMLFDYIAECI 123 Query: 136 KAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQ 195 ++D+Q + + +PLGFTFSFP I++GIL WTKGF E ++VV +L+ Sbjct: 124 SDYLDQQNMK--HKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDA 181 Query: 196 ITKRN-IPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKL 254 I +R ++VVA++NDT T+++ YY D ++G+I GTG N Y + S++E ++G+ Sbjct: 182 IKRRGDFEMDVVAMVNDTVATMISCYYEDHHCEVGLIVGTGCNACYMEEMSNVELVEGE- 240 Query: 255 SDDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEI 313 M +N E+G+F D + R +YD +DE S PGQQ +EKM G Y+GE+ Sbjct: 241 ------EGRMCVNTEWGAFGDTGELEDFRLEYDRVVDEASLNPGQQLYEKMIGGKYMGEL 294 Query: 314 LRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINT 373 +RL L+ M + +F + K +T + ++IE D + + T ++ + G+ Sbjct: 295 VRLVLIKMVNENLLFGGESSEKLKTRGAFETQFVSQIEADTS-DFKQTLNILRT-LGVQA 352 Query: 374 TVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYK------TGHIAADGSVYNRYPGF 427 T+ + +R E + RAA + G+A I + + DGSVY +P F Sbjct: 353 TIGDCHAVRLACESVSTRAAIMCSAGLAGILNRMRQSRREELLRITVGVDGSVYKLHPSF 412 Query: 428 KEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQK 473 K+K + + + I + +E+GSG GAA+I+A+A K Sbjct: 413 KDKFHATVLKLTSGCE-------ITFIQSEEGSGRGAALISAVAYK 451 >1BDG-A nrPDB Length = 451 Score = 545 bits (1403), Expect = e-155, Method: Composition-based stats. Identities = 142/464 (30%), Positives = 240/464 (51%), Gaps = 19/464 (4%) Query: 16 MADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSK---KGGNIPMIPGWVMD 72 M ++L +++ K F + + + + GL K + +I M P +V Sbjct: 1 MVFSDQQLFEKVVEILKPFDLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTK 60 Query: 73 FPTGKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRTTQNPDELWEFIA 132 P G E+G+FLA+DLGGTN RV+ V L G Q + A + + + EL+++IA Sbjct: 61 TPNGTETGNFLALDLGGTNYRVLSVTLEGKGKSPRIQERTYCIPAEKMSGSGTELFKYIA 120 Query: 133 DSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPML 192 ++L F++ + + LGFTFSFP Q + L RWTKGF +E H+V +L Sbjct: 121 ETLADFLENNGMK--DKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELL 178 Query: 193 QKQITKRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQG 252 Q ++ KR + ++ VA++NDT GTL + DP+ +G+I GTG N AY + S +E + G Sbjct: 179 QTELDKRELNVKCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELMDG 238 Query: 253 KLSDDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLG 311 ++ IN E+G+F + + RT++D ++D +S PG+Q +EKM SG YLG Sbjct: 239 VKEPEV------VINTEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLG 292 Query: 312 EILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGI 371 E++R ++ + +Q +F+ + + T Y +E DP L +T + ++ + Sbjct: 293 ELVRHIIVYLVEQKILFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHV 352 Query: 372 NTTVQ-ERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGHIAADGSVYNRYPGFKEK 430 + +++R E++ RAA L+ GIA I ++ + DGS+Y +P F E+ Sbjct: 353 PVVEPIDNRIVRYACEMVVKRAAYLAGAGIACILRRINRSEVTVGVDGSLYKFHPKFCER 412 Query: 431 AANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKR 474 D+ + + +++ +EDGSG GAA IAA ++ Sbjct: 413 M----TDMVDKLKPKNTRFCLRL--SEDGSGKGAAAIAASCTRQ 450 >4DCH-A nrPDB Length = 473 Score = 541 bits (1393), Expect = e-154, Method: Composition-based stats. Identities = 141/473 (29%), Positives = 251/473 (53%), Gaps = 34/473 (7%) Query: 17 ADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLS---KKGGNIPMIPGWVMDF 73 A + +++E F + E L+ V + E+++GL + ++ M+P +V Sbjct: 6 ARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRST 65 Query: 74 PTGKESGDFLAIDLGGTNLRVVLVKLG----GDRTFDTTQSKYRLPDAMRTTQNPDELWE 129 P G E GDFL++DLGGTN RV+LVK+G G + T Y +P+ T + L++ Sbjct: 66 PEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPED-AMTGTAEMLFD 124 Query: 130 FIADSLKAFIDEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVV 189 +I++ + F+D+ + + +PLGFTFSFP I++GIL WTKGF E ++VV Sbjct: 125 YISECISDFLDKHQMK--HKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVV 182 Query: 190 PMLQKQITKRN-IPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIE 248 +L+ I +R ++VVA++NDT T+++ YY D + ++G+I GTG N Y + ++E Sbjct: 183 GLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVE 242 Query: 249 KLQGKLSDDIPPSAPMAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSG 307 ++G M +N E+G+F D+ + +YD +DE S PGQQ +EK+ G Sbjct: 243 LVEG-------DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGG 295 Query: 308 YYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQN 367 Y+GE++RL L+ + + +F + + +T + +++E D + + + L + Sbjct: 296 KYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNIL--S 353 Query: 368 EFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRGYKTG------HIAADGSVY 421 G+ + + ++RR E + RAA + G+A + + + DGSVY Sbjct: 354 TLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVY 413 Query: 422 NRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQKR 474 +P FKE+ +++ + + I + +E+GSG GAA+++A+A K+ Sbjct: 414 KLHPSFKERFHASVRRLTPSCE-------ITFIESEEGSGRGAALVSAVACKK 459 >3HM8-A nrPDB Length = 445 Score = 539 bits (1388), Expect = e-153, Method: Composition-based stats. Identities = 146/457 (31%), Positives = 243/457 (53%), Gaps = 29/457 (6%) Query: 25 QQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGNIPMIPGWVMDFPTGKESGDFLA 84 + +E F + + L AV + KGL + ++ M+P +V P G E GDFLA Sbjct: 4 RLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASSLRMLPTFVRATPDGSERGDFLA 63 Query: 85 IDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLKAFIDEQFP 144 +DLGGTN RV+LV++ T Y +P+ + + +L++ I D + F +Q Sbjct: 64 LDLGGTNFRVLLVRV--TTGVQITSEIYSIPETV-AQGSGQQLFDHIVDCIVDFQQKQGL 120 Query: 145 QGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITKRN-IPI 203 G + +PLGFTFSFP Q +++GIL WTKGF + E DVV +L++ IT+R + + Sbjct: 121 SG--QSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVEL 178 Query: 204 EVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDDIPPSAP 263 VVA++NDT GT+++ Y DP ++G+I GTG N Y + ++ + G S Sbjct: 179 NVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPG-------DSGR 231 Query: 264 MAINCEYGSF-DNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLALMDMY 322 M IN E+G+F D+ + + T++D ++D+ S PG+Q FEKM SG YLGEI+R L+ + Sbjct: 232 MCINMEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLT 291 Query: 323 KQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTVQERKLIR 382 G +F+ Q + + + T + + IE D L + + + G+ T + ++ Sbjct: 292 SLGVLFRGQQIQRLQTRDIFKTKFLSEIESDSLA-LRQVRAILE-DLGLPLTSDDALMVL 349 Query: 383 RLSELIGARAARLSVCGIAAICQKRGYKTG------HIAADGSVYNRYPGFKEKAANALK 436 + + + RAA+L G+AA+ +K G + DG++Y +P F A ++ Sbjct: 350 EVCQAVSQRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVR 409 Query: 437 DIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAALAQK 473 ++ + + +EDGSG GAA++ A+A + Sbjct: 410 ELAPRC-------VVTFLQSEDGSGKGAALVTAVACR 439 >5ZQT-A nrPDB Length = 473 Score = 507 bits (1305), Expect = e-144, Method: Composition-based stats. Identities = 162/463 (34%), Positives = 239/463 (51%), Gaps = 34/463 (7%) Query: 27 IENFEKIFTVPTETLQAVTKHFISELEKGLS-KKGGNIPMIPGWVMDFPTGKESGDFLAI 85 IE E+ F+ PT L+ + + E+E+GL + M+ +V + PTG E G F A+ Sbjct: 16 IEEVEQRFSTPTALLRGIADAMVEEMERGLRADPHAPLKMLISYVDNLPTGDEHGLFYAL 75 Query: 86 DLGGTNLRVVLVKLGGDRTFDTTQSKYRL---PDAMRTTQNPDELWEFIADSLKAFI--- 139 DLGGTN RV+ V+LGG +Q + P M T EL++FIA L++F+ Sbjct: 76 DLGGTNFRVIRVQLGGREKRVVSQQYEEVAIPPHLMVGTSM--ELFDFIAAELESFVKTE 133 Query: 140 --DEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQIT 197 D P+G LGFTFSFP Q I+ G L +WTKGF I DVV L + + Sbjct: 134 GEDFHLPEGRQRE--LGFTFSFPVHQTSISSGTLIKWTKGFSINGTVGEDVVAELSRAME 191 Query: 198 KRNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDD 257 ++ + ++V AL+NDT GTL Y D + VI GTG N AY + + I K G L Sbjct: 192 RQGLDMKVTALVNDTVGTLAGGRYVDNDVAAAVILGTGTNAAYVEHANAIPKWTGLL--- 248 Query: 258 IPPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLA 317 P S M IN E+G+F +E + PR+ YD +D ES PG+Q +EKM SG YLGEI+R Sbjct: 249 -PRSGNMVINMEWGNFKSERL--PRSDYDNALDFESLNPGEQIYEKMISGMYLGEIVRRI 305 Query: 318 LMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGI-NTTVQ 376 L+ + +F + +K ++ F++ T + + D +L+ ++ G+ +T+++ Sbjct: 306 LLKLAHDASLFGDVVPTKLEQRFILRTPDMSAMHHDTSHDLKHLGAKLKDILGVADTSLE 365 Query: 377 ERKLIRRLSELIGARAARLSVCGIAAICQKRGYK----------TGHIAADGSVYNRYPG 426 R + + +L+ R ARL+ GI I +K G IA DG +Y Y Sbjct: 366 ARYITLHVCDLVAERGARLAAAGIYGILKKLGRDRVPSDGSQKQRTVIALDGGLYEHYKK 425 Query: 427 FKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAA 469 F+ L D+ G S + + A DGSG GAA++AA Sbjct: 426 FRTCLEATLADLLGEEAAS----SVVVKLANDGSGIGAALLAA 464 >4QS9-A nrPDB Length = 474 Score = 503 bits (1296), Expect = e-143, Method: Composition-based stats. Identities = 162/460 (35%), Positives = 240/460 (52%), Gaps = 30/460 (6%) Query: 27 IENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGN-IPMIPGWVMDFPTGKESGDFLAI 85 ++ FE+ P L+ V E+ GL+ GG+ + M+ +V + P+G E G F A+ Sbjct: 19 LKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKGLFYAL 78 Query: 86 DLGGTNLRVVLVKLGGDRT--FDTTQSKYRLPDAMRTTQNPDELWEFIADSLKAFI---- 139 DLGGTN RV+ V LGG + + +P + T DEL+ FIA++L F+ Sbjct: 79 DLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHL-MTGGSDELFNFIAEALAKFVATEC 137 Query: 140 -DEQFPQGISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITK 198 D P+G LGFTF+FP Q ++ G L +WTKGF I DVV L K + + Sbjct: 138 EDFHLPEGRQRE--LGFTFAFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALER 195 Query: 199 RNIPIEVVALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDDI 258 + + + AL+NDT GTL Y +P+ VI GTG N AY + + I K G L Sbjct: 196 VGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLL---- 251 Query: 259 PPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLAL 318 P S M IN E+G+F + H+ P T++D T+D ES PG+Q EK+ SG YLGEILR L Sbjct: 252 PKSGEMVINMEWGNFRSSHL--PLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVL 309 Query: 319 MDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTT-VQE 377 + M + F + SK PF++ T + + + D +L+ ++ + TT ++ Sbjct: 310 LKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKM 369 Query: 378 RKLIRRLSELIGARAARLSVCGIAAICQKRGYKTGH--------IAADGSVYNRYPGFKE 429 RK++ L +I R ARLS GI I +K G T IA DG ++ Y F E Sbjct: 370 RKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSE 429 Query: 430 KAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIAA 469 ++LK++ G + +++ + DGSG GAA++AA Sbjct: 430 CMESSLKELLGDEASG----SVEVTHSNDGSGIGAALLAA 465 >2YHX-A nrPDB Length = 457 Score = 374 bits (959), Expect = e-104, Method: Composition-based stats. Identities = 152/446 (34%), Positives = 210/446 (47%), Gaps = 10/446 (2%) Query: 27 IENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGNIPMIPGWVMDFPTGKESGDFLAID 86 +E +F VP LQAV ++ +IPM+PGWV+ +G ++G FLAI Sbjct: 9 VEVHXXVFIVPPXILQAVVS-ILTTRXDDXDSSAASIPMVPGWVLKQVSGAQAGSFLAIV 67 Query: 87 LGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLKAFIDEQFPQG 146 +GG +L V+L+ L G + S+ L AM TT P +LW A S A Sbjct: 68 MGGGDLEVILISLAGRQESSIXASR-SLAAAMSTTAIPSDLWGNXAXS-NAAFSSXEFSS 125 Query: 147 ISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITKRNIPIEVV 206 + +PLGFTF ++ + +G + F + + ++ + V Sbjct: 126 XAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAXLXK--LISAMXNAXFPAGDXXXSV 183 Query: 207 ALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDDIPPSAPMAI 266 A I D+ G L YTD KMG+IFG+GVN AY+ C + M I Sbjct: 184 ADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYW--CDSTXIGDAADGGXXGGAGXMXI 241 Query: 267 NCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLALMDMYKQGF 326 C+ SF LP+ Y T++ SP +TF K S G+ LR LM G Sbjct: 242 CCDQSSFRKAFPSLPQIXYLXTLNXXSP-XAXKTFXKNSXAKNXGQSLRDVLMXFKXXGQ 300 Query: 327 IFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTVQERKLIRRLSE 386 S F V +TSYPA+I++ P +L DLF + GI + ++RR Sbjct: 301 XHXXXAXS-FXAANVENTSYPAKIQKLPHFDLRXXXDLFXGDQGIAXKTXMKXVVRRXLF 359 Query: 387 LIGARAARLSVCGIAAICQKRGYKTGHIAADGSVYNRYPGFKEKAANALKDIYGWTQTSL 446 LI A A RL VC I AICQK+GY +GHIAA GS Y GF +A +IYGW Q++ Sbjct: 360 LIAAYAFRLVVCXIXAICQKKGYSSGHIAAXGSX-RSYSGFSXNSATXNXNIYGWPQSAX 418 Query: 447 DDYPIKIVPAEDGSGAGAAVIAALAQ 472 PI I PA DG GA + VI ++A Sbjct: 419 XSKPIXITPAIDGXGAASXVIXSIAS 444 >1HKG-A nrPDB Length = 457 Score = 360 bits (923), Expect = 1e-99, Method: Composition-based stats. Identities = 149/452 (32%), Positives = 208/452 (46%), Gaps = 10/452 (2%) Query: 27 IENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGNIPMIPGWVMDFPTGKESGDFLAID 86 +E +F VP LQAV + +IPM+PGWV+ G ++G FLAI Sbjct: 9 VEVHXXVFIVPPXILQAVVS-IATTRXDDXDSAAASIPMVPGWVLKQVXGSQAGSFLAIV 67 Query: 87 LGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRTTQNPDELWEFIADSLKAFIDEQFPQG 146 +GG +L V+L+ L G + S+ L +M TT P +LW A S A Sbjct: 68 MGGGDLEVILIXLAGYQESSIXASR-SLAASMXTTAIPSDLWGNXAXS-NAAFSSXEFSS 125 Query: 147 ISEPIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDVVPMLQKQITKRNIPIEVV 206 + +PLGFTF ++ + +G + F + + ++ + V Sbjct: 126 XAGSVPLGFTFXEAGAKEXVIKGQITXQAXAFSLAXLXK--LISAMXNAXFPAGDXXXXV 183 Query: 207 ALINDTTGTLVASYYTDPETKMGVIFGTGVNGAYYDVCSDIEKLQGKLSDDIPPSAPMAI 266 A I D+ G L YTD KMG+IFG+GVN AY+ C + + M + Sbjct: 184 ADIXDSHGILXXVNYTDAXIKMGIIFGSGVNAAYW--CDSTXIADAADAGXXGGAGXMXV 241 Query: 267 NCEYGSFDNEHVVLPRTKYDITIDEESPRPGQQTFEKMSSGYYLGEILRLALMDMYKQGF 326 C SF LP+ Y T++ SP +TFEK S G+ LR LM G Sbjct: 242 CCXQDSFRKAFPSLPQIXYXXTLNXXSP-XAXKTFEKNSXAKNXGQSLRDVLMXYKXXGQ 300 Query: 327 IFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTVQERKLIRRLSE 386 F V ++SYPA+I++ P +L DLF + GI + ++RR Sbjct: 301 XHXXXAXD-FXAANVENSSYPAKIQKLPHFDLRXXXDLFXGDQGIAXKTXMKXVVRRXLF 359 Query: 387 LIGARAARLSVCGIAAICQKRGYKTGHIAADGSVYNRYPGFKEKAANALKDIYGWTQTSL 446 LI A A RL VC I AICQK+GY +GHIAA GS Y GF +A +IYGW Q++ Sbjct: 360 LIAAYAFRLVVCXIXAICQKKGYSSGHIAAXGSX-RDYSGFSXNSATXNXNIYGWPQSAX 418 Query: 447 DDYPIKIVPAEDGSGAGAAVIAALAQKRIAEG 478 PI I PA DG GA VI ++A + Sbjct: 419 XSKPIXITPAIDGEGAAXXVIXSIASSQXXXA 450 >4W8B-A nrPDB Length = 386 Score = 31.6 bits (70), Expect = 0.82, Method: Composition-based stats. Identities = 33/151 (21%), Positives = 59/151 (39%), Gaps = 12/151 (7%) Query: 105 FDTTQSKYRLPDAMRTTQNP--DELWEFIADSLKAFIDEQFPQGISEPIPLGFTFSFPAS 162 ++ S + +A T++ +LW IA+ K + + G++EP FS Sbjct: 109 SKSSSSYQAVDEATITSKITRLKDLWTQIANEFKDYDEHLLFAGLNEPFQEYSLFS--GH 166 Query: 163 QNKINEGILQRWTKGF--DIPNIENHDVVPMLQKQITKRNIPIEVVALIND----TTG-T 215 ++ IL R+ + F + ++ L Q NI V + D T G Sbjct: 167 HEELTP-ILCRYNQAFVEAVRATGGNNAQRTLVVQGPSTNINSSVNYMTADKLPETAGRL 225 Query: 216 LVASYYTDPETKMGVIFGTGVNGAYYDVCSD 246 +V +Y DP G +G N Y+ ++ Sbjct: 226 MVEVHYYDPGQFCGTFDASGDNAFYFWGAAN 256 >2FEZ-A nrPDB Length = 388 Score = 30.8 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 13/74 (17%), Positives = 26/74 (35%), Gaps = 3/74 (4%) Query: 346 YPARIEEDPFENLEDTDDLFQNEFGINTTVQERKLIRRLSE---LIGARAARLSVCGIAA 402 Y + + D ++ GI+ R L R+ L ++A+ + G Sbjct: 216 YLSDRQSDALGAYRRVKTTLADDLGIDPGPTLRALNERILRQQPLDAKKSAKTTAAGTVT 275 Query: 403 ICQKRGYKTGHIAA 416 + +R +G A Sbjct: 276 VLDQRTMASGQQAV 289 >6MSK-b nrPDB Length = 377 Score = 30.4 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 20/74 (27%), Positives = 33/74 (44%), Gaps = 1/74 (1%) Query: 319 MDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFENLEDTDDLFQNEFGINTTVQER 378 M M QG F + + D MDTS PA+ EED ++ ++D + L + Sbjct: 291 MQMSLQGAEFGQAESADIDASSAMDTSEPAK-EEDDYDVMQDPEFLQSVLENLPGVDPNN 349 Query: 379 KLIRRLSELIGARA 392 + IR + ++A Sbjct: 350 EAIRNAMGSLASQA 363 >3BDK-A nrPDB Length = 386 Score = 29.6 bits (65), Expect = 3.3, Method: Composition-based stats. Identities = 16/76 (21%), Positives = 30/76 (39%) Query: 73 FPTGKESGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLPDAMRTTQNPDELWEFIA 132 P G S FL DL G + + L G + + + + + R + ++LW + Sbjct: 140 LPDGSTSLAFLKSDLAGVDPVADDLNLPGWDSSYSKEEMKAIIENYRQNISEEDLWANLE 199 Query: 133 DSLKAFIDEQFPQGIS 148 +KA + G+ Sbjct: 200 YFIKAILPTAEEAGVK 215 >2ITM-A nrPDB Length = 484 Score = 28.9 bits (63), Expect = 5.1, Method: Composition-based stats. Identities = 16/68 (23%), Positives = 35/68 (51%), Gaps = 1/68 (1%) Query: 82 FLAIDLGGTNLRVVLVKLGGDRTFDTTQSKY-RLPDAMRTTQNPDELWEFIADSLKAFID 140 ++ IDLG + ++V+L+ G+ T+ P + + Q+P++ W+ ++KA D Sbjct: 2 YIGIDLGTSGVKVILLNEQGEVVAAQTEKLTVSRPHPLWSEQDPEQWWQATDRAMKALGD 61 Query: 141 EQFPQGIS 148 + Q + Sbjct: 62 QHSLQDVK 69 >5KJW-A nrPDB Length = 427 Score = 28.1 bits (61), Expect = 8.8, Method: Composition-based stats. Identities = 17/91 (18%), Positives = 30/91 (32%), Gaps = 19/91 (20%) Query: 3 HLGPKKPQARKGSMADVPKELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLSKKGGN 62 H+ + P A K + E IF + + L + E G + + Sbjct: 200 HVEYQPPPAMKT---------YEPAETVVSIFKLTKDQLTTLKA---KSKEDGNTTTYSS 247 Query: 63 IPMIPGWV-------MDFPTGKESGDFLAID 86 M+ G V P +E+ ++A D Sbjct: 248 YEMLSGHVWRCTCLARGLPEEQETKLYIATD 278 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.316 0.135 0.357 Lambda K H 0.267 0.0412 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,081,539 Number of Sequences: 36641 Number of extensions: 795148 Number of successful extensions: 2560 Number of sequences better than 10.0: 22 Number of HSP's better than 10.0 without gapping: 35 Number of HSP's successfully gapped in prelim test: 16 Number of HSP's that attempted gapping in prelim test: 2312 Number of HSP's gapped (non-prelim): 61 length of query: 486 length of database: 10,336,785 effective HSP length: 101 effective length of query: 385 effective length of database: 6,636,044 effective search space: 2554876940 effective search space used: 2554876940 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 61 (28.1 bits)