BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P04798 (512 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6DWN-A nrPDB 998 0.0 2HI4-A nrPDB 743 0.0 6IQ5-A nrPDB 347 1e-95 6B82-A nrPDB 276 1e-74 4R20-A nrPDB 259 3e-69 5UYS-A nrPDB 255 4e-68 4R1Z-A nrPDB 250 8e-67 2PG7-A nrPDB 245 3e-65 1N6B-A nrPDB 242 4e-64 3TBG-A nrPDB 239 2e-63 4H1N-A nrPDB 239 2e-63 5W0C-A nrPDB 237 1e-62 3E6I-A nrPDB 231 6e-61 2NNH-A nrPDB 231 7e-61 4GQS-A nrPDB 227 9e-60 5E0E-A nrPDB 227 1e-59 3IBD-A nrPDB 226 1e-59 5E58-A nrPDB 222 3e-58 3DL9-A nrPDB 206 2e-53 3QZ1-A nrPDB 201 6e-52 5VBU-A nrPDB 189 3e-48 5YLW-A nrPDB 164 7e-41 5VEU-A nrPDB 109 3e-24 6DA2-A nrPDB 102 4e-22 3K9V-A nrPDB 101 6e-22 3JUS-A nrPDB 87 2e-17 6AYB-A nrPDB 86 3e-17 3EL3-A nrPDB 80 2e-15 6C94-A nrPDB 79 5e-15 2VE3-A nrPDB 75 7e-14 4KPA-A nrPDB 70 2e-12 4WMZ-A nrPDB 70 2e-12 2WX2-A nrPDB 69 5e-12 5FSA-A nrPDB 69 6e-12 3L4D-A nrPDB 68 1e-11 5JLC-A nrPDB 68 1e-11 3MDV-A nrPDB 66 3e-11 3S79-A nrPDB 66 5e-11 3N9Z-A nrPDB 65 6e-11 3MZS-A nrPDB 63 4e-10 2W0A-A nrPDB 62 6e-10 5M0P-A nrPDB 61 9e-10 6M7X-A nrPDB 59 7e-09 3ABB-A nrPDB 58 1e-08 2Y5N-A nrPDB 57 2e-08 5YSW-A nrPDB 57 3e-08 6FYJ-A nrPDB 56 5e-08 4ZGX-A nrPDB 55 7e-08 6CR2-A nrPDB 54 2e-07 3AWQ-A nrPDB 53 3e-07 3NC3-A nrPDB 53 4e-07 5LIE-A nrPDB 52 7e-07 2ZBZ-A nrPDB 51 1e-06 6F0B-A nrPDB 50 2e-06 2ZQJ-A nrPDB 50 3e-06 4GGV-A nrPDB 49 4e-06 2FR7-A nrPDB 49 4e-06 2X2N-A nrPDB 49 5e-06 5VWS-A nrPDB 49 6e-06 6G5O-A nrPDB 49 7e-06 1EHE-A nrPDB 48 9e-06 4OQR-A nrPDB 48 9e-06 4Z5Q-A nrPDB 48 9e-06 4OQS-A nrPDB 48 1e-05 3TKT-A nrPDB 48 1e-05 5HDI-A nrPDB 47 1e-05 4RM4-A nrPDB 47 3e-05 3EJB-B nrPDB 46 3e-05 2Z36-A nrPDB 46 3e-05 1CPT-A nrPDB 46 3e-05 5XW2-A nrPDB 46 4e-05 4WPZ-A nrPDB 46 5e-05 5Y1I-A nrPDB 46 5e-05 4JBT-A nrPDB 46 5e-05 6G71-A nrPDB 46 5e-05 3TYW-A nrPDB 45 6e-05 6A7J-A nrPDB 45 7e-05 6B11-A nrPDB 45 1e-04 3OFT-A nrPDB 44 1e-04 5EX6-C nrPDB 44 1e-04 2X9P-A nrPDB 44 2e-04 5XJN-A nrPDB 44 2e-04 6DCD-A nrPDB 44 2e-04 3MGX-A nrPDB 44 2e-04 4DO1-A nrPDB 43 3e-04 3P3Z-A nrPDB 43 3e-04 5GWE-A nrPDB 43 3e-04 6A7I-A nrPDB 43 4e-04 5OFQ-A nrPDB 43 4e-04 6GK6-A nrPDB 42 7e-04 3ABA-A nrPDB 42 7e-04 1WIY-A nrPDB 42 9e-04 5YHJ-A nrPDB 42 9e-04 3A1L-A nrPDB 41 0.001 4XE3-A nrPDB 41 0.001 5Z9I-A nrPDB 41 0.002 2IJ7-A nrPDB 40 0.002 3A50-A nrPDB 40 0.002 5FOI-A nrPDB 40 0.002 5IT1-A nrPDB 40 0.003 2QBO-A nrPDB 40 0.003 5NWS-A nrPDB 39 0.005 5L1U-A nrPDB 39 0.005 4YZR-A nrPDB 39 0.005 2RFC-A nrPDB 39 0.006 6FSH-A nrPDB 39 0.006 5DE9-A nrPDB 39 0.006 4UBS-A nrPDB 39 0.008 1LG9-A nrPDB 38 0.009 2UUQ-A nrPDB 38 0.011 3WVS-A nrPDB 38 0.013 2WIO-A nrPDB 38 0.013 5L94-A nrPDB 38 0.013 6HQG-A nrPDB 37 0.014 2VZM-A nrPDB 37 0.017 1Z8P-A nrPDB 37 0.021 4YT3-A nrPDB 37 0.022 5LIV-A nrPDB 37 0.023 6F88-A nrPDB 37 0.026 3B98-A nrPDB 37 0.027 4TX3-A nrPDB 37 0.030 6M7L-A nrPDB 36 0.031 5DQN-A nrPDB 36 0.034 3RWL-A nrPDB 36 0.035 1UED-A nrPDB 36 0.036 6GII-A nrPDB 36 0.037 2IAG-A nrPDB 35 0.054 6HQW-A nrPDB 35 0.058 3SN5-A nrPDB 35 0.067 5FYF-A nrPDB 35 0.081 1F4U-A nrPDB 35 0.083 2WIY-A nrPDB 35 0.097 5KYO-A nrPDB 34 0.13 5HIW-A nrPDB 34 0.14 1Q5D-A nrPDB 34 0.18 4MM0-A nrPDB 34 0.19 5D3U-A nrPDB 33 0.21 5XNT-A nrPDB 33 0.24 2RCM-A nrPDB 33 0.31 6GMF-A nrPDB 33 0.34 1ODO-A nrPDB 33 0.43 1UE8-A nrPDB 32 0.45 2NZA-A nrPDB 32 0.51 3BUJ-A nrPDB 32 0.63 4TRI-A nrPDB 32 0.64 2XKR-A nrPDB 32 0.79 3NV6-A nrPDB 32 0.85 5OMS-A nrPDB 32 0.91 3DBM-A nrPDB 30 1.7 5H1Z-A nrPDB 30 1.9 1NO7-A nrPDB 30 2.1 3IVY-A nrPDB 30 2.6 5GRN-A nrPDB 29 6.3 >6DWN-A nrPDB Length = 491 Score = 998 bits (2579), Expect = 0.0, Method: Compositional matrix adjust. Identities = 478/478 (100%), Positives = 478/478 (100%) Query: 35 KGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ 94 KGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ Sbjct: 8 KGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ 67 Query: 95 ALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASS 154 ALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASS Sbjct: 68 ALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASS 127 Query: 155 TSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQEL 214 TSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQEL Sbjct: 128 TSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQEL 187 Query: 215 LSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFE 274 LSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFE Sbjct: 188 LSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFE 247 Query: 275 KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 334 KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV Sbjct: 248 KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 307 Query: 335 MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDT 394 MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDT Sbjct: 308 MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDT 367 Query: 395 SLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGK 454 SLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGK Sbjct: 368 SLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGK 427 Query: 455 RKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS 512 RKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS Sbjct: 428 RKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS 485 >2HI4-A nrPDB Length = 495 Score = 743 bits (1917), Expect = 0.0, Method: Compositional matrix adjust. Identities = 355/486 (73%), Positives = 414/486 (85%), Gaps = 3/486 (0%) Query: 25 VIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVV 84 V++ RP+VPKGLK+PP PWGWPL+GH+LTLGKNPHLALSRMSQ+YGDVLQIRIGSTPV+ Sbjct: 3 VLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVL 62 Query: 85 VLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKS 144 VLS LDTIRQALVRQGDDFKGRPDLYT TLI++GQS++FS DSGPVWAARRRLAQN L + Sbjct: 63 VLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNT 122 Query: 145 FSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFG 204 FSIASDPASS+SCYLEEHVSKEA+ LIS LQELMAGPGHF+PY VVVSV NVI A+CFG Sbjct: 123 FSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFG 182 Query: 205 RRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQK 264 + + + E+LSLV + F E SGNP DF PILRYLPNP+L FK N++F F+QK Sbjct: 183 QHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQK 242 Query: 265 MVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTT 324 V+EHY+ F+K +RDIT +L +H + K + N+ + EKI+N+V D+FGAGFDTVTT Sbjct: 243 TVQEHYQDFDKNSVRDITGALFKHSK-KGPRASGNL-IPQEKIVNLVNDIFGAGFDTVTT 300 Query: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPF 384 AISWSLMYLV P +QRKIQ+ELDTVIGR RRPRLSDR LPY+EAFILETFRHSSF+PF Sbjct: 301 AISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPF 360 Query: 385 TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG-AIDKVL 443 TIPHSTTRDT+L GFYIPK CVFVNQWQ+NHD +LW +PSEF PERFLT DG AI+K L Sbjct: 361 TIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPL 420 Query: 444 SEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACC 503 SEK+++FGMGKR+CIGE +A+WE+FLFLAILLQ++EFSVP GVKVD+TPIYGLTMKHA C Sbjct: 421 SEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARC 480 Query: 504 EHFQMQ 509 EH Q + Sbjct: 481 EHVQAR 486 >6IQ5-A nrPDB Length = 463 Score = 347 bits (889), Expect = 1e-95, Method: Compositional matrix adjust. Identities = 183/446 (41%), Positives = 266/446 (59%), Gaps = 10/446 (2%) Query: 60 HLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQ 119 HL+ +R++++YGDV QIR+GS P+VVL+G I QALV+QG F RP +F ++S G+ Sbjct: 4 HLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGR 63 Query: 120 SMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMA 179 SM+F S W +RR A + +++F P S LE HV EA L++ L A Sbjct: 64 SMAFGHYSEH-WKVQRRAAHSMMRNF-FTRQPRSRQ--VLEGHVLSEARELVALLVRGSA 119 Query: 180 GPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPI 239 +P VV+V NV+ A+CFG RY H+ E L++ N FG VG+G+ D +P Sbjct: 120 DGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPW 179 Query: 240 LRYLPNPSLNAFKD---LNEKFYSFMQKMVKEHYKTFEKGHI-RDITDSLIEHCQEKQLD 295 L+Y PNP F++ LN F +F+ H ++ G RD+ D+ I ++K Sbjct: 180 LQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAG 239 Query: 296 EN--ANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGR 353 ++ +L E + + D+FGA DT++TA+ W L+ P VQ ++Q ELD V+GR Sbjct: 240 DSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGR 299 Query: 354 SRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQ 413 R P + D+ +LPY+ AF+ E R SSFVP TIPH+TT +TS+ G++IPK VFVNQW Sbjct: 300 DRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWS 359 Query: 414 INHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAI 473 +NHD W NP F P RFL DG I+K L+ +V+IF +GKR+CIGE +++ ++FLF++I Sbjct: 360 VNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISI 419 Query: 474 LLQRVEFSVPLGVKVDMTPIYGLTMK 499 L + +F M YGLT+K Sbjct: 420 LAHQCDFRANPNEPAKMNFSYGLTIK 445 >6B82-A nrPDB Length = 509 Score = 276 bits (707), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 157/476 (32%), Positives = 253/476 (53%), Gaps = 22/476 (4%) Query: 33 VPKGLKNPPGPWGWPLIGHMLTLGKN--PHLALSRMSQQYGDVLQIRIGSTPVVVLSGLD 90 VP G ++PP P+IG +++L + PH+ + ++YGD+ + +GS +++++ Sbjct: 18 VPAGNRSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHH 77 Query: 91 TIRQALVRQGDDFKGRPDLYTFTLIS-NGQSMSFSPDSGPVWAARRRLAQNGLKSFSIAS 149 ++ L+++G F GRP T L++ +G+ ++F+ D W R++ L F Sbjct: 78 HAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFA-DYSSTWKFHRKMVHGALCMFG--- 133 Query: 150 DPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDH 209 S +E+ + +EA + L E P + +VTNV+CA+CF Y Sbjct: 134 ----EGSVSIEKIICREASSMCEVLTESQNSAVDLGPE--LTRAVTNVVCALCFNSSYKR 187 Query: 210 NHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEH 269 E S++ + + V + D P L+ PN L + +QK +EH Sbjct: 188 GDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLRILRQCISIRDKLLQKKYEEH 247 Query: 270 YKTFEKGHIRDITDSLIEHCQEKQLDENAN-----VQLSDEKIINIVLDLFGAGFDTVTT 324 T+ RD+ D+L+ + K+ EN N V L+++ ++ V ++FGAG +T TT Sbjct: 248 KVTYSDNVQRDLLDALL---RAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTT 304 Query: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPF 384 + WS+ YLV NP+VQRKIQEELD+ IG+ R P+LSDR +LPY+EA I E R P Sbjct: 305 TLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPL 364 Query: 385 TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLS 444 IPH +D+S+ + + KG V +N W ++HD+K W NP F P RFL +G S Sbjct: 365 LIPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPS 424 Query: 445 EKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKV-DMTPIYGLTMK 499 + FG G R C+GE +A+ E+FLFLA +LQR +P G + D+ +G+ ++ Sbjct: 425 GSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQ 480 >4R20-A nrPDB Length = 486 Score = 259 bits (661), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 145/427 (33%), Positives = 227/427 (53%), Gaps = 18/427 (4%) Query: 59 PHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNG 118 PHL +++S QYG + + G +V+S + +R+ L+++G +F GRP + T L++ G Sbjct: 41 PHLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQG 100 Query: 119 -QSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQEL 177 + ++F+ D P+W RRL + F S+ L+ V + A+ L +EL Sbjct: 101 GKDIAFA-DYSPLWKNHRRLVHSSFTLFGEGSN-------KLQTIVQEAADSLC---EEL 149 Query: 178 MAGPGHFNPYRYVVV-SVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADF 236 A G + V++ +VTNVIC + F Y + EL +++ N+ + + G D Sbjct: 150 QACRGQSSDLSVVLMRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGGLVDI 209 Query: 237 IPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDE 296 P LR PN L K+ + K + EH K+ G RD+ D+L+ +Q Sbjct: 210 FPWLRIFPNKDLKRLKECVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALL---IGQQRGS 266 Query: 297 NANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRR 356 ++++ ++ + FGAG +T +T + W++ +L+ +P++Q ++Q ELD +G R Sbjct: 267 GGADDITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRP 326 Query: 357 PRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINH 416 P LSDR HLP ++A + E R P IPH +DTSL G +PKG V VN W I+H Sbjct: 327 PCLSDRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHH 386 Query: 417 DQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ 476 D K W P +F PERFL P G K + FG G R C+GE++AR E+FLF++ LQ Sbjct: 387 DPKHWDQPEQFNPERFLEPSG--KKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQ 444 Query: 477 RVEFSVP 483 R FS P Sbjct: 445 RFSFSCP 451 >5UYS-A nrPDB Length = 494 Score = 255 bits (651), Expect = 4e-68, Method: Compositional matrix adjust. Identities = 152/459 (33%), Positives = 241/459 (52%), Gaps = 25/459 (5%) Query: 36 GLKNPPGPWGWPLIGHMLTLGKNPHLALS--RMSQQYGDVLQIRIGSTPVVVLSGLDTIR 93 G K P PL+G + L ++ H+ + ++ ++YG + +R+G+ V++ + Sbjct: 6 GAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAK 65 Query: 94 QALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPAS 153 + L+++G DF GRP + T + SN + DSG W RRLA + +F++ D Sbjct: 66 EVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLA---MATFALFKDGDQ 122 Query: 154 STSCYLEEHVSKEAEVLISTLQELMAG-PGHFNPYRY-VVVSVTNVICAICFGRRYDHNH 211 LE+ + +E ISTL +++A G + V V+VTNVI ICF Y + Sbjct: 123 K----LEKIICQE----ISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGD 174 Query: 212 QELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYK 271 EL + N N + + + D +P L+ PN +L K + + K+++ + + Sbjct: 175 PELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKE 234 Query: 272 TFEKGHIRDITDSLIEHCQEKQLDENANVQ-------LSDEKIINIVLDLFGAGFDTVTT 324 F I ++ D+L+ Q K +N N LSD I+ + D+FGAG +T T+ Sbjct: 235 KFRSDSITNMLDTLM---QAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTS 291 Query: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPF 384 + W+L +L+ NP+V++K+ EE+D +G SR P +SDR+ L +EA I E R P Sbjct: 292 VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPM 351 Query: 385 TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLS 444 IPH D+S+ F + KG V +N W ++H++K W P +F+PERFL P G S Sbjct: 352 LIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPS 411 Query: 445 EKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483 + FG G R CIGE +AR E+FL +A LLQR + VP Sbjct: 412 VSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 450 >4R1Z-A nrPDB Length = 439 Score = 250 bits (639), Expect = 8e-67, Method: Compositional matrix adjust. Identities = 144/429 (33%), Positives = 226/429 (52%), Gaps = 20/429 (4%) Query: 78 IGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLIS-NGQSMSFSPDSGPVWAARRR 136 +GS +++++ ++ L+++G F GRP T L++ +G+ ++F+ D W R+ Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFA-DYSSTWKFHRK 59 Query: 137 LAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTN 196 + L F S +E+ + +EA + L E P + +VTN Sbjct: 60 MVHGALCMFG-------EGSVSIEKIICREASSMCEVLTESQNSAVDLGPE--LTRAVTN 110 Query: 197 VICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNE 256 V+CA+CF Y E S++ + + V + D P L+ PN L + Sbjct: 111 VVCALCFNSSYKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLTILRQCIS 170 Query: 257 KFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENAN-----VQLSDEKIINIV 311 +QK +EH T+ RD+ D+L+ + K+ EN N V L+++ ++ V Sbjct: 171 IRDKLLQKKYEEHKVTYSDNVQRDLLDALL---RAKRSSENNNSSTRDVGLTEDHVLMTV 227 Query: 312 LDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAF 371 D+FGAG +T TT + WS+ YLV NP+VQRKIQEELD+ IG+ R P+LSDR +LPY+EA Sbjct: 228 GDIFGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEAT 287 Query: 372 ILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPER 431 I E R P IPH +D+S+ + + KG V +N W ++HD+K W NP F P R Sbjct: 288 IREVLRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGR 347 Query: 432 FLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKV-DM 490 FL +G S + FG G R C+GE +A+ E+FLFLA +LQR +P G + D+ Sbjct: 348 FLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDL 407 Query: 491 TPIYGLTMK 499 +G+ ++ Sbjct: 408 QGKFGVVLQ 416 >2PG7-A nrPDB Length = 476 Score = 245 bits (626), Expect = 3e-65, Method: Compositional matrix adjust. Identities = 146/460 (31%), Positives = 241/460 (52%), Gaps = 21/460 (4%) Query: 38 KNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQAL 96 K PPGP P IG+ L L + + +L ++S++YG V I +G VVVL G D +R+AL Sbjct: 10 KLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREAL 69 Query: 97 VRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTS 156 V Q ++F GR + TF + G + FS +G RR + L+ F + Sbjct: 70 VDQAEEFSGRGEQATFDWVFKGYGVVFS--NGERAKQLRRFSIATLRDFGVGKRG----- 122 Query: 157 CYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLS 216 +EE + +EA LI L+ G + +P ++ +V+NVI +I FG R+D+ +E LS Sbjct: 123 --IEERIQEEAGFLIDALRG--TGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLS 178 Query: 217 LVNLNNNFGEVVGSGNP---ADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTF 273 L+ + + + F ++++LP P AF+ L + F+ K V+ + +T Sbjct: 179 LLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQ-LLQGLEDFIAKKVEHNQRTL 237 Query: 274 EKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYL 333 + RD DS + QE++ +N N + + ++ L LF G +TV+T + + + L Sbjct: 238 DPNSPRDFIDSFLIRMQEEE--KNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLL 295 Query: 334 VMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRD 393 + +P V+ K+ EE+D VIG++R+P+ DR+ +PYMEA I E R +P ++ +D Sbjct: 296 MKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKD 355 Query: 394 TSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMG 453 T + F++PKG V+ + D + NP +F P+ FL G K S+ + F +G Sbjct: 356 TKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKK--SDAFVPFSIG 413 Query: 454 KRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTP 492 KR C GE +AR E+FLF ++Q K +D++P Sbjct: 414 KRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSP 453 >1N6B-A nrPDB Length = 473 Score = 242 bits (617), Expect = 4e-64, Method: Compositional matrix adjust. Identities = 145/445 (32%), Positives = 241/445 (54%), Gaps = 27/445 (6%) Query: 38 KNPPGPWGWPLIGHMLTL-GKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQAL 96 K PPGP +P+IG++L + K+ +L++ S+ YG V + +G P VVL G + +++AL Sbjct: 10 KLPPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLHGYEAVKEAL 69 Query: 97 VRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTS 156 V G++F GR + +S G ++FS + W RR + L++F + Sbjct: 70 VDLGEEFAGRGSVPILEKVSKGLGIAFS--NAKTWKEMRRFSLMTLRNFGMGKRS----- 122 Query: 157 CYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLS 216 +E+ + +EA L+ L++ A P +P + + NVIC++ F R+D+ +E L Sbjct: 123 --IEDRIQEEARCLVEELRKTNASPC--DPTFILGCAPCNVICSVIFHNRFDYKDEEFLK 178 Query: 217 LVNLNNNFGEVVGSGNP-----ADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYK 271 L+ + E++G+ P +F +L Y P K+ + +F+ + VKEH K Sbjct: 179 LMESLHENVELLGT--PWLQVYNNFPALLDYFPGIHKTLLKNAD-YIKNFIMEKVKEHQK 235 Query: 272 TFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLM 331 + + RD D C ++++ N++ + E ++ V DLFGAG +T +T + +SL+ Sbjct: 236 LLDVNNPRDFID-----CFLIKMEQENNLEFTLESLVIAVSDLFGAGTETTSTTLRYSLL 290 Query: 332 YLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTT 391 L+ +P V ++QEE++ VIGR R P + DRS +PY +A I E R +P +PH+ T Sbjct: 291 LLLKHPEVAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVT 350 Query: 392 RDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFG 451 RD + ++IPKG + + + HD+K + NP F P FL G K S+ + F Sbjct: 351 RDVRFRNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKK--SDYFMPFS 408 Query: 452 MGKRKCIGETIARWEVFLFLAILLQ 476 GKR C+GE +AR E+FLFL +LQ Sbjct: 409 AGKRMCVGEGLARMELFLFLTSILQ 433 >3TBG-A nrPDB Length = 479 Score = 239 bits (610), Expect = 2e-63, Method: Compositional matrix adjust. Identities = 138/435 (31%), Positives = 230/435 (52%), Gaps = 21/435 (4%) Query: 57 KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLIS 116 +N ++ +++GDV +++ TPVVVL+GL +R+ALV G+D RP + ++ Sbjct: 30 QNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILG 89 Query: 117 NGQSMS--FSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTL 174 G F GP W +RR + + L++ + LE+ V++EA L + Sbjct: 90 FGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKK-------SLEQWVTEEAACLCAAF 142 Query: 175 QELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSG--- 231 P F P + +V+NVI ++ GRR++++ L L++L G SG Sbjct: 143 ANHSGRP--FRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE-GLKEESGFLR 199 Query: 232 NPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHI-RDITDSLIEHCQ 290 + +P+L ++P + + + F + + +++ EH T++ RD+T++ + + Sbjct: 200 EVLNAVPVLLHIPALAGKVLR-FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEME 258 Query: 291 EKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTV 350 + + N +DE + +V DLF AG T +T ++W L+ ++++P VQR++Q+E+D V Sbjct: 259 KAK--GNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDV 316 Query: 351 IGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVN 410 IG+ RRP + D++H+PY A I E R VP + H T+RD ++GF IPKG + N Sbjct: 317 IGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITN 376 Query: 411 QWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLF 470 + D+ +W P F PE FL G V E + F G+R C+GE +AR E+FLF Sbjct: 377 LSSVLKDEAVWEKPFRFHPEHFLDAQGHF--VKPEAFLPFSAGRRACLGEPLARMELFLF 434 Query: 471 LAILLQRVEFSVPLG 485 LLQ FSVP G Sbjct: 435 FTSLLQHFSFSVPTG 449 >4H1N-A nrPDB Length = 479 Score = 239 bits (610), Expect = 2e-63, Method: Compositional matrix adjust. Identities = 147/461 (31%), Positives = 244/461 (52%), Gaps = 23/461 (4%) Query: 38 KNPPGPWGWPLIGHMLTLGKNPHL-ALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQAL 96 K PPGP P++G++L + + L + R+ ++YGDV + +GS PVVVL G D IR+AL Sbjct: 10 KLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLCGTDAIREAL 69 Query: 97 VRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTS 156 V Q + F GR + I G + F+ +G W A RR + ++ F + Sbjct: 70 VDQAEAFSGRGKIAVVDPIFQGYGVIFA--NGERWRALRRFSLATMRDFGMGKRS----- 122 Query: 157 CYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVT-NVICAICFGRRYDHNHQELL 215 +EE + +EA L+ +EL G + S+T N+IC+I FG+R+D+ L Sbjct: 123 --VEERIQEEARCLV---EELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFL 177 Query: 216 SLVNLNNNFGEVVGSGNPADF---IPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKT 272 L++L ++ S + F L+Y P +++L E +F+ + V++H T Sbjct: 178 RLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQE-INTFIGQSVEKHRAT 236 Query: 273 FEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMY 332 + + RD D + ++ + D ++ + + +I VL LF AG +T +T + + + Sbjct: 237 LDPSNPRDFIDVYLLRMEKDKSDPSS--EFHHQNLILTVLSLFAAGTETTSTTLRYGFLL 294 Query: 333 LVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR 392 ++ P V ++Q+E++ VIG R P L DR+ +PY +A I E R +PF +PH+ T+ Sbjct: 295 MLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTK 354 Query: 393 DTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGM 452 DT +G+ IPK VF HD + + P+ F P FL +GA+ + +E + F + Sbjct: 355 DTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKR--NEGFMPFSL 412 Query: 453 GKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTP 492 GKR C+GE IAR E+FLF +LQ + P+ + +D+TP Sbjct: 413 GKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTP 453 >5W0C-A nrPDB Length = 477 Score = 237 bits (604), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 147/463 (31%), Positives = 249/463 (53%), Gaps = 25/463 (5%) Query: 38 KNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQAL 96 K PPGP P+IG++L +G K+ +L+ +S+ YG V + G P+VVL G + +++AL Sbjct: 11 KLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEAL 70 Query: 97 VRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTS 156 + G++F GR + G + FS +G W RR + L++F + Sbjct: 71 IDLGEEFSGRGIFPLAERANRGFGIVFS--NGKKWKEIRRFSLMTLRNFGMGKRS----- 123 Query: 157 CYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLS 216 +E+ V +EA L+ L++ A P +P + + NVIC+I F +R+D+ Q+ L+ Sbjct: 124 --IEDRVQEEARCLVEELRKTKASPC--DPTFILGCAPCNVICSIIFHKRFDYKDQQFLN 179 Query: 217 LVNLNNNFGEVVGSGNP-----ADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYK 271 L+ N +++ S P +F PI+ Y P K++ S++ + VKEH + Sbjct: 180 LMEKLNENIKILSS--PWIQICNNFSPIIDYFPGTHNKLLKNV-AFMKSYILEKVKEHQE 236 Query: 272 TFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLM 331 + + + +D D + ++++ N + + E + N +DLFGAG +T +T + ++L+ Sbjct: 237 SMDMNNPQDFIDCFLMKMEKEK--HNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALL 294 Query: 332 YLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTT 391 L+ +P V K+QEE++ VIGR+R P + DRSH+PY +A + E R+ +P ++PH+ T Sbjct: 295 LLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVT 354 Query: 392 RDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFG 451 D + + IPKG + ++ + HD K + NP F P FL G K S+ + F Sbjct: 355 CDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKK--SKYFMPFS 412 Query: 452 MGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTPI 493 GKR C+GE +A E+FLFL +LQ + K +D TP+ Sbjct: 413 AGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPV 455 >3E6I-A nrPDB Length = 476 Score = 231 bits (589), Expect = 6e-61, Method: Compositional matrix adjust. Identities = 147/465 (31%), Positives = 243/465 (52%), Gaps = 28/465 (6%) Query: 38 KNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQAL 96 K PPGP+ P+IG++ L KN + +R++Q++G V + +GS +VV+ G +++AL Sbjct: 10 KLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEAL 69 Query: 97 VRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTS 156 + D+F GR DL F + + F ++GP W RR + L+++ + Sbjct: 70 LDYKDEFSGRGDLPAFH-AHRDRGIIF--NNGPTWKDIRRFSLTTLRNYGMGKQGN---- 122 Query: 157 CYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLS 216 E + +EA L+ L++ P F+P + + NVI I F + +D+N ++ L Sbjct: 123 ---ESRIQREAHFLLEALRKTQGQP--FDPTFLIGCAPCNVIADILFRKHFDYNDEKFLR 177 Query: 217 LVNL-NNNFGEVVGSGNP-----ADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHY 270 L+ L N NF + P +F L YLP K++ E ++ + VKEH+ Sbjct: 178 LMYLFNENFHLL---STPWLQLYNNFPSFLHYLPGSHRKVIKNVAE-VKEYVSERVKEHH 233 Query: 271 KTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330 ++ + RD+TD L+ ++++ +A + + I V DLF AG +T +T + + L Sbjct: 234 QSLDPNCPRDLTDCLLVEMEKEK--HSAERLYTMDGITVTVADLFFAGTETTSTTLRYGL 291 Query: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390 + L+ P ++ K+ EE+D VIG SR P + DR +PYM+A + E R + VP +PH Sbjct: 292 LILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEA 351 Query: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIF 450 TRDT +G+ IPKG V + +D + + +P +F PE FL +G S+ F Sbjct: 352 TRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFK--YSDYFKPF 409 Query: 451 GMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTPIY 494 GKR C GE +AR E+FL L +LQ + K +D++PI+ Sbjct: 410 STGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIH 454 >2NNH-A nrPDB Length = 476 Score = 231 bits (588), Expect = 7e-61, Method: Compositional matrix adjust. Identities = 149/447 (33%), Positives = 237/447 (53%), Gaps = 28/447 (6%) Query: 38 KNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQAL 96 K PPGP P+IG+ML + K+ + + S+ YG V + G P+VV G + +++AL Sbjct: 10 KLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEAL 69 Query: 97 VRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTS 156 + G++F GR + I+ G + S +G W RR + L++F + Sbjct: 70 IDNGEEFSGRGNSPISQRITKGLGIISS--NGKRWKEIRRFSLTTLRNFGMGKRS----- 122 Query: 157 CYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLS 216 +E+ V +EA L+ L++ A P +P + + NVIC++ F +R+D+ Q L+ Sbjct: 123 --IEDRVQEEAHCLVEELRKTKASPC--DPTFILGCAPCNVICSVVFQKRFDYKDQNFLT 178 Query: 217 LVN-LNNNFGEVVGSGNP-----ADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHY 270 L+ N NF ++ S P +F ++ P K++ S++++ VKEH Sbjct: 179 LMKRFNENF-RILNS--PWIQVCNNFPLLIDCFPGTHNKVLKNV-ALTRSYIREKVKEHQ 234 Query: 271 KTFEKGHIRDITDS-LIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWS 329 + + + RD D LI+ QEK +N + + E ++ V DLF AG +T +T + + Sbjct: 235 ASLDVNNPRDFIDCFLIKMEQEK---DNQKSEFNIENLVGTVADLFVAGTETTSTTLRYG 291 Query: 330 LMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHS 389 L+ L+ +P V K+QEE+D VIGR R P + DRSH+PY +A + E R+S VP +PH+ Sbjct: 292 LLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHA 351 Query: 390 TTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVII 449 T DT + + IPKG + + HD K + NP+ F P FL +G K S+ + Sbjct: 352 VTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKK--SDYFMP 409 Query: 450 FGMGKRKCIGETIARWEVFLFLAILLQ 476 F GKR C GE +AR E+FLFL +LQ Sbjct: 410 FSAGKRICAGEGLARMELFLFLTTILQ 436 >4GQS-A nrPDB Length = 477 Score = 227 bits (579), Expect = 9e-60, Method: Compositional matrix adjust. Identities = 148/464 (31%), Positives = 242/464 (52%), Gaps = 27/464 (5%) Query: 38 KNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQAL 96 K PPGP P+IG++L + K+ +L+ +S+ YG V + G +VVL G + +++AL Sbjct: 11 KLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEAL 70 Query: 97 VRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTS 156 + G++F GR + G + FS +G W RR + L++F + Sbjct: 71 IDLGEEFSGRGHFPLAERANRGFGIVFS--NGKRWKEIRRFSLMTLRNFGMGKRS----- 123 Query: 157 CYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLS 216 +E+ V +EA L+ L++ A P +P + + NVIC+I F +R+D+ Q+ L+ Sbjct: 124 --IEDRVQEEARCLVEELRKTKASPC--DPTFILGCAPCNVICSIIFQKRFDYKDQQFLN 179 Query: 217 LVNLNNNFGEVVGSGNP-----ADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYK 271 L+ N +V + P +F I+ Y P K+L ++K VKEH + Sbjct: 180 LMEKLNENIRIVST--PWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK-VKEHQE 236 Query: 272 TFEKGHIRDITDS-LIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330 + + + RD D LI+ +EKQ N + + E ++ DL GAG +T +T + ++L Sbjct: 237 SMDINNPRDFIDCFLIKMEKEKQ---NQQSEFTIENLVITAADLLGAGTETTSTTLRYAL 293 Query: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390 + L+ +P V K+QEE++ V+GR+R P + DR H+PY +A + E R+ +P ++PH+ Sbjct: 294 LLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAV 353 Query: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIF 450 T D + + IPKG + + + HD K + NP F P FL G K S + F Sbjct: 354 TCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK--SNYFMPF 411 Query: 451 GMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTPI 493 GKR C+GE +AR E+FLFL +LQ + K +D TP+ Sbjct: 412 SAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPV 455 >5E0E-A nrPDB Length = 463 Score = 227 bits (578), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 135/435 (31%), Positives = 222/435 (51%), Gaps = 20/435 (4%) Query: 62 ALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSM 121 + R+ ++YGDV + +G PVV+L G + IR+ALV Q + F GR + I G + Sbjct: 26 SFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTIAVVEPIFRGYGV 85 Query: 122 SFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGP 181 F+ +G W A RR + ++ F + +EE + +EA L+ ++ P Sbjct: 86 VFA--NGERWKALRRFSLVTMRDFGMGKRS-------VEERIQEEARCLVEEFRKSQGAP 136 Query: 182 GHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADF---IP 238 +P N+IC+I FG R+D+ + L L+ L ++ S + F Sbjct: 137 --LDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFSG 194 Query: 239 ILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENA 298 L+Y P ++L E ++ + V++H T + H RD D+ + ++++ N Sbjct: 195 FLKYFPGTHRQISRNLQE-ILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEK--SNQ 251 Query: 299 NVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPR 358 + + + ++ VL LF AG +T +T + + + ++ P V K+Q+E+D VIG R P Sbjct: 252 HTEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPT 311 Query: 359 LSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQ 418 L DR+ +PY EA I E R S +P +PH T+DT +G+ +PK V+ HD Sbjct: 312 LEDRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDP 371 Query: 419 KLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 + + P F P+ FL +GA+ K SE + F +GKR C+GE IAR E+FLF +LQ Sbjct: 372 QYFEQPDTFNPDHFLDANGALKK--SEAFMPFSIGKRICLGEGIARNELFLFFTTILQNF 429 Query: 479 EFSVPLGVK-VDMTP 492 S P+ K +D++P Sbjct: 430 SLSSPVAPKDIDLSP 444 >3IBD-A nrPDB Length = 476 Score = 226 bits (577), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 137/433 (31%), Positives = 228/433 (52%), Gaps = 22/433 (5%) Query: 65 RMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFS 124 R ++YGDV + +G PVV+L G++ IR+ALV + + F GR + G + F+ Sbjct: 38 RFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFA 97 Query: 125 PDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHF 184 +G W RR + ++ F + +EE + +EA+ LI +EL G Sbjct: 98 --NGNRWKVLRRFSVTTMRDFGMGKRS-------VEERIQEEAQCLI---EELRKSKGAL 145 Query: 185 NPYRYVVVSVT-NVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGS--GNPAD-FIPIL 240 ++ S+T N+IC+I FG+R+ + QE L ++NL ++ S G + F L Sbjct: 146 MDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFL 205 Query: 241 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV 300 ++ P +K+L E +++ V++H +T + RD+ D+ + H ++++ NA+ Sbjct: 206 KHFPGAHRQVYKNLQE-INAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEK--SNAHS 262 Query: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360 + S + + L LF AG +T +T + + + ++ P V ++ E++ VIG R P L Sbjct: 263 EFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELH 322 Query: 361 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 420 DR+ +PY EA I E R S +P +PH T+ TS +G+ IPK VF+ HD Sbjct: 323 DRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHY 382 Query: 421 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 480 + P F P+ FL +GA+ K +E I F +GKR C+GE IAR E+FLF +LQ Sbjct: 383 FEKPDAFNPDHFLDANGALKK--TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSM 440 Query: 481 SVPLGVK-VDMTP 492 + P+ + +D+TP Sbjct: 441 ASPVAPEDIDLTP 453 >5E58-A nrPDB Length = 493 Score = 222 bits (566), Expect = 3e-58, Method: Compositional matrix adjust. Identities = 132/432 (30%), Positives = 220/432 (50%), Gaps = 20/432 (4%) Query: 65 RMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFS 124 R+ ++YGDV + +G PVV+L G + IR+ALV Q + F GR + + M FS Sbjct: 57 RIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTIAVIKPVIGDYGMIFS 116 Query: 125 PDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHF 184 +G W RR + ++ F + +E+ + +EA+ L+ LQ+ P Sbjct: 117 --NGERWKVLRRFSLATMRDFGMGKRS-------VEDRIQEEAQCLVEELQKSQGAP--L 165 Query: 185 NPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADF---IPILR 241 +P N+IC+I FG RYD+ ++ L L++L ++ S + F ++ Sbjct: 166 DPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFSGFMK 225 Query: 242 YLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQ 301 Y P ++L E ++ + V++H T + + RD D+ + ++++ N + + Sbjct: 226 YFPGAHRQITRNLQE-ILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEK--SNQHTE 282 Query: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSD 361 + ++ VL LF AG +T +T + + + ++ P V K+Q+E+D VIG R P L D Sbjct: 283 FHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLED 342 Query: 362 RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLW 421 R+ +PY +A I E R S P PH T+DT +G+ +PK V+ HD + + Sbjct: 343 RTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQYF 402 Query: 422 VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFS 481 P F P+ FL +GA+ K SE + F +GKR C+GE IAR E+FLF +LQ S Sbjct: 403 EQPGTFNPDHFLDANGALKK--SEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSVS 460 Query: 482 VPLGVK-VDMTP 492 + K +D++P Sbjct: 461 SSVAPKDIDLSP 472 >3DL9-A nrPDB Length = 479 Score = 206 bits (524), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 122/446 (27%), Positives = 222/446 (49%), Gaps = 22/446 (4%) Query: 59 PHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNG 118 PH+ + + SQ YG++ + +G VVL+G D +++ LV Q + F RP L F ++ Sbjct: 36 PHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM 95 Query: 119 QSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELM 178 + + G W RRLA N + F E + +E + ++ Sbjct: 96 GGL-LNSRYGRGWVDHRRLAVNSFRYFGYGQKS-------FESKILEETKFFNDAIETYK 147 Query: 179 AGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSG-----NP 233 P F+ + + +V+N+ I FG R+ + + ++ L + E+ S N Sbjct: 148 GRP--FDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNA 205 Query: 234 ADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQ 293 +I IL + + L F++ Y F+ +++++ + + D+ ++ + + Sbjct: 206 FPWIGILPFGKHQQL--FRNA-AVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGK 262 Query: 294 LDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGR 353 D ++ S E +I V +L AG +T T + W+++++ + P +Q ++Q+E+D ++G Sbjct: 263 NDPSST--FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGP 320 Query: 354 SRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQ 413 + +P D+ +PY EA + E R + VP I H+T+ D ++G+ IPKG V N + Sbjct: 321 NGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYS 380 Query: 414 INHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAI 473 ++ D+K W +P F PERFL G K E ++ F +G+R C+GE +AR E+FLF Sbjct: 381 VHFDEKYWRDPEVFHPERFLDSSGYFAK--KEALVPFSLGRRHCLGEHLARMEMFLFFTA 438 Query: 474 LLQRVEFSVPLGVKVDMTPIYGLTMK 499 LLQR P + D+ P G+T++ Sbjct: 439 LLQRFHLHFPHELVPDLKPRLGMTLQ 464 >3QZ1-A nrPDB Length = 496 Score = 201 bits (511), Expect = 6e-52, Method: Compositional matrix adjust. Identities = 136/439 (30%), Positives = 224/439 (51%), Gaps = 33/439 (7%) Query: 47 PLI-GHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKG 105 PL+ G + L N + L ++Q+ G V ++R+G VVVL+ TI +A++R+ DF G Sbjct: 32 PLVPGFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAG 91 Query: 106 RPDLYTFTLISN-GQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVS 164 RP + ++ L+S Q +S D +W A ++L ++ L T +E V Sbjct: 92 RPQIPSYKLVSQRCQDISLG-DYSLLWKAHKKLTRSAL---------LLGTRSSMEPWVD 141 Query: 165 KEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD---HN-HQELLSLVNL 220 + + ++ P + + ++IC + FG + D H H + L+ Sbjct: 142 QLTQEFCERMRVQAGAPVTIQ--KEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDLMKT 199 Query: 221 NNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRD 280 +++ S D +P LR+ PNP L K E ++K ++ H ++ G RD Sbjct: 200 WDHW-----SIQILDMVPFLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRD 254 Query: 281 ITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQ 340 +TD +++ ++++E QL + + V+DLF G +T + +SW++ +L+ +P +Q Sbjct: 255 MTDYMLQGVGRQRVEEGPG-QLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQ 313 Query: 341 RKIQEELDTVIG---RSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLK 397 R++QEELD +G R DR+ LP + A I E R VP +PH TTR +S+ Sbjct: 314 RRLQEELDRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIF 373 Query: 398 GFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKC 457 G+ IP+G V N + D+ +W P EF P+RFL P GA L+ FG G R C Sbjct: 374 GYDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEP-GANPSALA-----FGCGARVC 427 Query: 458 IGETIARWEVFLFLAILLQ 476 +GE++AR E+F+ LA LLQ Sbjct: 428 LGESLARLELFVVLARLLQ 446 >5VBU-A nrPDB Length = 476 Score = 189 bits (479), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 124/426 (29%), Positives = 209/426 (49%), Gaps = 44/426 (10%) Query: 66 MSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLIS-NGQSMSFS 124 ++Q++G + ++ +G VVVL+ TI +A+V++ DF GRP+ T+ L+S N +S Sbjct: 33 LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLG 92 Query: 125 PDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELM-AGPGH 183 D +W A ++L ++ L + + + E L E M A PG Sbjct: 93 -DYSLLWKAHKKLTRSAL-------------LLGIRDSMEPVVEQLTQEFCERMRAQPGT 138 Query: 184 FNPYRYVVVSVT-NVICAICFGRRYDHNHQELLSLVNLNNNFGEVVG---------SGNP 233 +T ++IC + FG + + NL + + + S Sbjct: 139 PVAIEEEFSLLTCSIICYLTFGDKIKDD--------NLMPAYYKCIQEVLKTWSHWSIQI 190 Query: 234 ADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQ 293 D IP LR+ PNP L K EK ++ +++H ++ G RD+ D +++ + Sbjct: 191 VDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPS 250 Query: 294 LDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIG- 352 ++E + QL + + +DL G +T +SW++++L+ +P +Q+++QEELD +G Sbjct: 251 MEEGSG-QLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGP 309 Query: 353 --RSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVN 410 S R DR+ LP + A I E R VP +PH TTR +S+ G+ IP+G + N Sbjct: 310 GASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPN 369 Query: 411 QWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLF 470 + D+ +W P EF P+RFL P + + + FG G R C+GE +AR E+F+ Sbjct: 370 LQGAHLDETVWERPHEFWPDRFLEPGK------NSRALAFGCGARVCLGEPLARLELFVV 423 Query: 471 LAILLQ 476 L LLQ Sbjct: 424 LTRLLQ 429 >5YLW-A nrPDB Length = 495 Score = 164 bits (416), Expect = 7e-41, Method: Compositional matrix adjust. Identities = 118/451 (26%), Positives = 207/451 (45%), Gaps = 25/451 (5%) Query: 40 PPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQ 99 PPGP+ +P++G+ML LG NPH +++S++YG ++ I +GS V++S + ++ L R Sbjct: 29 PPGPFPYPIVGNMLQLGANPHQVFAKLSKRYGPLMSIHLGSLYTVIVSSPEMAKEILHRH 88 Query: 100 GDDFKGRPDLYTFTLISNGQ-SMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCY 158 G F GR + + SM F P + W R++ + + FS S AS Sbjct: 89 GQVFSGRTIAQAVHACDHDKISMGFLPVASE-WRDMRKICKEQM--FSNQSMEAS----- 140 Query: 159 LEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRY-DHNHQELLSL 217 + ++ + L+ +Q+ + ++ N++ A F + + + + + Sbjct: 141 -QGLRRQKLQQLLDHVQKCSDSGRAVDIREAAFITTLNLMSATLFSSQATEFDSKATMEF 199 Query: 218 VNLNNNFGEVVGSGNPADFIPILRYLPNPSLNA-----FKDLNEKFYSFMQKMVKEHYKT 272 + +VG N AD+ PILR + F L K ++ + ++ Sbjct: 200 KEIIEGVATIVGVPNFADYFPILRPFDPQGVKRRADVFFGKLLAKIEGYLNERLESKRAN 259 Query: 273 FEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMY 332 D + +++ Q + +L +++LDLF G DT TT+I W++ Sbjct: 260 PNAPKKDDFLEIVVDIIQANEF------KLKTHHFTHLMLDLFVGGSDTNTTSIEWAMSE 313 Query: 333 LVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR 392 LVMNP +++ EL +V G + S LPY++A I E R P +P Sbjct: 314 LVMNPDKMARLKAELKSVAGDEKIVDESAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAES 373 Query: 393 DTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAID-KVLSEKVIIFG 451 D + G+ IPKG + +N + I D +W +P F PERFL D ID K +++ FG Sbjct: 374 DQEVNGYLIPKGTQILINAYAIGRDPSIWTDPETFDPERFL--DNKIDFKGQDYELLPFG 431 Query: 452 MGKRKCIGETIARWEVFLFLAILLQRVEFSV 482 G+R C G +A + + A L+ ++ + Sbjct: 432 SGRRVCPGMPLATRILHMATATLVHNFDWKL 462 >5VEU-A nrPDB Length = 480 Score = 109 bits (272), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 113/465 (24%), Positives = 199/465 (42%), Gaps = 64/465 (13%) Query: 41 PGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQG 100 PGP PL+G++L+ + + ++YG + G PV+ ++ D IR LV++ Sbjct: 18 PGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE- 76 Query: 101 DDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPA-------- 152 +++ +N +S+ GPV + + S+A D Sbjct: 77 ----------CYSVFTNRRSL------GPVGFMK--------SAISLAEDEEWKRIRSLL 112 Query: 153 --SSTSCYLEEH---VSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRY 207 + TS L+E +++ +VL+ L+ +VI FG Sbjct: 113 SPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNI 172 Query: 208 DHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLN-AFKDLNEKFY-----SF 261 D + V F + G +P F+ I+ + P L F+ LN + +F Sbjct: 173 DSLNNPQDPFVESTKKFLKF-GFLDPL-FLSIILF---PFLTPVFEALNVSLFPKDTINF 227 Query: 262 MQKMVKEHYKTF---EKGHIRDITDSLIEHCQEKQLDEN---ANVQLSDEKIINIVLDLF 315 + K V K+ ++ H D +I+ K+ + + ++++L+ + II I Sbjct: 228 LSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIF---- 283 Query: 316 GAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILET 375 AG++T ++ +S++L L +P VQ+K+Q+E+D V+ P + Y++ + ET Sbjct: 284 -AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNET 342 Query: 376 FRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTP 435 R V + + +D + G +IPKG V + + ++HD K W P EF PERF Sbjct: 343 LRLFP-VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK 401 Query: 436 DGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 480 +ID + FG G R CIG A + L L +LQ F Sbjct: 402 KDSIDPYIYTP---FGTGPRNCIGMRFALMNMKLALIRVLQNFSF 443 >6DA2-A nrPDB Length = 487 Score = 102 bits (254), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 115/468 (24%), Positives = 191/468 (40%), Gaps = 69/468 (14%) Query: 41 PGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQG 100 PGP P +G++L+ K + ++YG V G PV+ ++ D I+ LV++ Sbjct: 19 PGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE- 77 Query: 101 DDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPA-------- 152 +++ +N + GPV + + SIA D Sbjct: 78 ----------CYSVFTNRRPF------GPVGFMK--------SAISIAEDEEWKRLRSLL 113 Query: 153 --SSTSCYLEEHV---SKEAEVLISTLQELMAGPGHFNPYRYVVVSVT-NVICAICFGRR 206 + TS L+E V ++ +VL+ L+ A G + V + + +VI + FG Sbjct: 114 SPTFTSGKLKEMVPIIAQYGDVLVRNLRR-EAETGKPVTLKDVFGAYSMDVITSTSFGVN 172 Query: 207 YDHNHQELLSLVNLNNNFGEVVGSGNPADF--------------IPILRYLPNPSLNAFK 252 D SL N + F E DF IPIL L ++ F Sbjct: 173 ID-------SLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVL---NICVFP 222 Query: 253 DLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVL 312 F K +KE + H D +I+ K+ + + LSD +++ + Sbjct: 223 REVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHK--ALSDLELVAQSI 280 Query: 313 DLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFI 372 AG++T ++ +S+ + L +P VQ+K+QEE+D V+ P + Y++ + Sbjct: 281 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 340 Query: 373 LETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERF 432 ET R + + +D + G +IPKG V + + ++ D K W P +FLPERF Sbjct: 341 NETLRLFP-IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF 399 Query: 433 LTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 480 + D + FG G R CIG A + L L +LQ F Sbjct: 400 SKKNK--DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSF 445 >3K9V-A nrPDB Length = 482 Score = 101 bits (252), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 104/471 (22%), Positives = 205/471 (43%), Gaps = 55/471 (11%) Query: 41 PGPWGWPLIGHMLTLG-----KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQA 95 PGP WPL+G +L + K H L+ ++YG + ++++GS V L G ++ +A Sbjct: 27 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEA 85 Query: 96 LVRQGDDFKGRPDLYTFTLISNGQSMSFSPD--SGPVWAARRRLAQNGL-KSFSIASDPA 152 L R R ++ + + ++ ++ G W R Q L K I Sbjct: 86 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK--- 142 Query: 153 SSTSCYLEEHVSKEAEVLISTLQELMAGPGHF-NPYRYVVVSVTNVICAICFGRRY---- 207 L++ +++ + + EL G + Y + IC + + +R+ Sbjct: 143 ------LDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQ 196 Query: 208 DHNHQELLSLVN----LNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQ 263 +E L+ + + + FG+++ + P + K LN K + Sbjct: 197 KETEEEALTFITAIKTMMSTFGKMMVT--PVEL--------------HKRLNTKVWQAHT 240 Query: 264 KMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV----QLSDEKIINIVLDLFGAGF 319 +K+ + I + L + Q+ D ++ LS +++ V +L A Sbjct: 241 LAWDTIFKSVKPC----IDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAV 296 Query: 320 DTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHS 379 +T ++ W L L NP+ QR++ +E+ +V+ ++ PR D ++PY++A + E+ R + Sbjct: 297 ETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLT 356 Query: 380 SFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAI 439 VPFT + + T L + +PKG + +N + + + + +F PER+L + I Sbjct: 357 PSVPFTT-RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKI 415 Query: 440 DKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDM 490 + + FG+GKR CIG +A ++ L L ++Q+ + V+M Sbjct: 416 NPFAH---LPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEM 463 >3JUS-A nrPDB Length = 461 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 107/466 (22%), Positives = 200/466 (42%), Gaps = 53/466 (11%) Query: 29 SRPQVPKGLKNPPGPWG-WPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLS 87 ++ +P G+K+PP + P +GH + GK+P L ++YG V + L Sbjct: 2 AKKTLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLL 61 Query: 88 GLDTIRQALVRQGDDFKGRPDLYT-FTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFS 146 G D + +D D+Y+ T G+ +++ + PV+ ++++ ++GL + Sbjct: 62 GSDAAALLFNSKNEDLNAE-DVYSRLTTPVFGKGVAYDVPN-PVFLEQKKMLKSGL---N 116 Query: 147 IASDPASSTSCYLEEHVS---KEAEVLISTLQELMAGPGHFNPYRYV--VVSVTNVICAI 201 IA + ++HVS KE + + E G N + + ++ +T C Sbjct: 117 IA---------HFKQHVSIIEKETKEYFESWGE----SGEKNVFEALSELIILTASHCLH 163 Query: 202 CFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLN----AFKDLNEK 257 R N + +L+ F A +P +LP PS A +++ + Sbjct: 164 GKEIRSQLNEKVAQLYADLDGGFSHA------AWLLP--GWLPLPSFRRRDRAHREIKDI 215 Query: 258 FYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGA 317 FY +QK + K I DI +L++ + L+D+++ +++ L A Sbjct: 216 FYKAIQKRRQSQEK------IDDILQTLLDATYKD------GRPLTDDEVAGMLIGLLLA 263 Query: 318 GFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDR-SHLPYMEAFILETF 376 G T +T +W +L + +Q+K E TV G + P D+ L ++ I ET Sbjct: 264 GQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETL 323 Query: 377 RHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPD 436 R + + + T T + G+ IP G V V+ + WV +F P+R+L + Sbjct: 324 RLRPPIMIMMRMARTPQT-VAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDN 382 Query: 437 GAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSV 482 A + + + FG G+ +CIGE A ++ + +L+ EF + Sbjct: 383 PASGEKFA--YVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL 426 >6AYB-A nrPDB Length = 466 Score = 86.3 bits (212), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 110/449 (24%), Positives = 185/449 (41%), Gaps = 39/449 (8%) Query: 35 KGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG---LDT 91 KG P P P +G ++ KNP + S++YGDV I + L+ LDT Sbjct: 8 KGKLPPRVPNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFLNHPKILDT 67 Query: 92 IRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKS--FSIAS 149 +A D+ D+Y F G + + DS + + +GL + F + Sbjct: 68 FFKAT----DNELSLRDVYRFMRPVFGTGVVYDADSTERMMEQVKFVSSGLTTARFRVFV 123 Query: 150 DPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDH 209 D + + + E V ++ ELMA ++ T C + R Sbjct: 124 DIFEDEIAHKVKELGPEGTVDVA---ELMAD----------LIIFTASRCLLGDEVR--- 167 Query: 210 NHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLN-AFKDLNEKFYSFMQKMVKE 268 + LS NL + ++ +P F LP P + A K + E F + K +E Sbjct: 168 ---QYLSEKNLGKLYHDIDDGISPLSFF--YPSLPAPKRDKARKAVGEIFQELLDKRREE 222 Query: 269 HYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISW 328 H K E+ D +++H ++ + +L+D I I++ AG T + SW Sbjct: 223 HKKHPERLLDESKMD-VVDHLLTQKYKDGQ--ELTDVHRIGILIAGLFAGQHTSSITSSW 279 Query: 329 SLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPH 388 +LM ++ N +V K+++E + ++G + + Y+EA + E R + P + Sbjct: 280 TLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRM--YPPLIMIM 337 Query: 389 STTRD-TSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKV 447 R + + IPKG + V+ + NP F PER LT +K Sbjct: 338 RMARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPER-LTERKEHEK-FKYGA 395 Query: 448 IIFGMGKRKCIGETIARWEVFLFLAILLQ 476 + FG G+ KCIGE A +V ++ILL+ Sbjct: 396 VPFGAGRHKCIGENFALLQVKSIISILLR 424 >3EL3-A nrPDB Length = 467 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 111/457 (24%), Positives = 194/457 (42%), Gaps = 44/457 (9%) Query: 31 PQVPKGLKNPP-GPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGL 89 P P+ L+ PP G PL+GH L ++P LA + +GDV++I++G V ++ Sbjct: 16 PGAPE-LREPPVAGGGVPLLGHGWRLARDP-LAFMSQLRDHGDVVRIKLGPKTVYAVTNP 73 Query: 90 DTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIAS 149 + + AL D P + + + ++ + +GP+ +RR Q +F + + Sbjct: 74 E-LTGALALNPDYHIAGPLWESLEGLLGKEGVATA--NGPLHRRQRRTIQ---PAFRLDA 127 Query: 150 DPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICF--GRRY 207 PA +EE EA L Q PG V + A C G+ Sbjct: 128 IPAYGP--IMEE----EAHALTERWQ-----PGKTVDATSESFRVAVRVAARCLLRGQYM 176 Query: 208 DHNHQEL---LSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQK 264 D + L L+ V VV G P+ R LP P+ F D + + + Sbjct: 177 DERAERLCVALATVFRGMYRRMVVPLG------PLYR-LPLPANRRFNDALADLHLLVDE 229 Query: 265 MVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTT 324 ++ E + +K D L+ E + D+N + + +++I + V+ + G +T+ + Sbjct: 230 IIAERRASGQK------PDDLLTALLEAK-DDNGD-PIGEQEIHDQVVAILTPGSETIAS 281 Query: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPF 384 I W L L +P +I++E++ V G R D L + I+E R V + Sbjct: 282 TIMWLLQALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAV-W 339 Query: 385 TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLS 444 + ++ L G+ IP G + + + I D K + + EF P+R+L P+ A + V Sbjct: 340 VLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWL-PERAAN-VPK 397 Query: 445 EKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFS 481 + F GKRKC + + ++ L A L + F Sbjct: 398 YAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFE 434 >6C94-A nrPDB Length = 497 Score = 79.0 bits (193), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 111/474 (23%), Positives = 190/474 (40%), Gaps = 57/474 (12%) Query: 41 PGPWGWPLIGHMLTLGKNPHL-ALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQ 99 PGP L GH L + K L + +QQ+ + +G + +A+ + Sbjct: 25 PGPPTHWLFGHALEIQKTGSLDKVVTWTQQFPYAHPLWVGQFIGFLNIYEPDYAKAVYSR 84 Query: 100 GDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNG-----LKSFSIASDPASS 154 GD PD+Y F L G+ + GP W R+L G LK + A S Sbjct: 85 GD--PKAPDVYDFFLQWIGKGLLVL--DGPKWFQHRKLLTPGFHYDVLKPYVAIF--ADS 138 Query: 155 TSCYLEEHVSKEAE------------VLISTLQELMAGPG-----HFNPYRYVVVSVTNV 197 T LE+ K E + + TL + G G H + YV VS + Sbjct: 139 TRIMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSYYVAVSELTL 198 Query: 198 ICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEK 257 + Q+ + +N+F + + + F+ R + + + Sbjct: 199 LM------------QQRIDSFQYHNDFIYWL-TPHGRRFLRACRAAHDHTDRVIRQRKAA 245 Query: 258 FYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGA 317 + KE K + H+ D D L++ + + VQLSD + V Sbjct: 246 L-----QDEKEREKIQNRRHL-DFLDILLD------VRGESGVQLSDTDLRAEVDTFMFE 293 Query: 318 GFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFR 377 G DT T+ ISW L + + P Q++ +EE+ ++G + D + + Y+ + E FR Sbjct: 294 GHDTTTSGISWFLYCMALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFR 353 Query: 378 HSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG 437 VP + + + G +P G + ++ + ++ + +W +P F P RF +P+ Sbjct: 354 LYPPVPQVYRQLSKPVSFVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRF-SPEN 412 Query: 438 AIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSV-PLGVKVDM 490 + + I F G R CIG+ A E+ + A+ L R EFSV PL + + + Sbjct: 413 SSGR-HPYAFIPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSVDPLRLPIKL 465 >2VE3-A nrPDB Length = 444 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 104/458 (22%), Positives = 191/458 (41%), Gaps = 54/458 (11%) Query: 40 PPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQ 99 PPG +G P +G L + R QQ+G + + R+ V+ +SG R ++ Sbjct: 14 PPGDFGLPWLGETLNFLNDGDFGKKR-QQQFGPIFKTRLFGKNVIFISGALANRFLFTKE 72 Query: 100 GDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNG-----LKSFSIASDPASS 154 + F+ L T L+ + + G + +RR++ L S+ D Sbjct: 73 QETFQATWPLSTRILLGPN---ALATQMGEIHRSRRKILYQAFLPRTLDSYLPKMD--GI 127 Query: 155 TSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQEL 214 YLE+ K EV+ Y + +V + G + N Q Sbjct: 128 VQGYLEQW-GKANEVIW---------------YPQLRRMTFDVAATLFMGEKVSQNPQ-- 169 Query: 215 LSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVK--EHYKT 272 L + + + S +PI LPN + + ++K++K + Sbjct: 170 --LFPWFETYIQGLFS------LPI--PLPNTLFGKSQRARALLLAELEKIIKARQQQPP 219 Query: 273 FEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMY 332 E+ + + + ++ Q L E L D+ I+L LF AG +T+T+A+S + Sbjct: 220 SEEDALGILLAARDDNNQPLSLPE-----LKDQ----ILLLLF-AGHETLTSALSSFCLL 269 Query: 333 LVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR 392 L + ++ ++++E + + S+ +PY++ + E R V + Sbjct: 270 LGQHSDIRERVRQEQNK-LQLSQELTAETLKKMPYLDQVLQEVLRLIPPVGGGF-RELIQ 327 Query: 393 DTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGM 452 D +GF+ PKG V Q + D L+ +P +F PERF TPDG+ + FG Sbjct: 328 DCQFQGFHFPKGWLVSYQISQTHADPDLYPDPEKFDPERF-TPDGSATHNPPFAHVPFGG 386 Query: 453 GKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDM 490 G R+C+G+ AR E+ LF L+Q+ ++++ G +++ Sbjct: 387 GLRECLGKEFARLEMKLFATRLIQQFDWTLLPGQNLEL 424 >4KPA-A nrPDB Length = 494 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 64/221 (28%), Positives = 99/221 (44%), Gaps = 13/221 (5%) Query: 282 TDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQR 341 +D L+ H + D L DE I ++ AG +T + +S++L +LV NP V + Sbjct: 254 SDDLLTHMLNGK-DPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQ 312 Query: 342 KIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVP-FTIPHSTTRDTSLKGFY 400 K EE V+ P L Y+ + E R P F++ DT L G Y Sbjct: 313 KAAEEAARVL-VDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSL--YAKEDTVLGGEY 369 Query: 401 -IPKGRCVFVNQWQINHDQKLWVNP-SEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCI 458 + KG + V Q++ D+ +W + EF PERF P + FG G+R CI Sbjct: 370 PLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSA----IPQHAFKPFGNGQRACI 425 Query: 459 GETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMK 499 G+ A E L L ++L+ +F ++D+ LT+K Sbjct: 426 GQQFALHEATLVLGMMLKHFDFEDHTNYELDIKET--LTLK 464 >4WMZ-A nrPDB Length = 539 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 72/278 (25%), Positives = 125/278 (44%), Gaps = 37/278 (13%) Query: 236 FIPILRYLPNPSLNAFK--DLNEKFYS-FMQKMVKEHYKTFEKGHIRDITDSLIEHCQEK 292 F PI PN L ++ D +K S ++KE K + RD+ DSL+++ K Sbjct: 236 FTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDI-QDRDLIDSLMKNSTYK 294 Query: 293 QLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIG 352 V+++D++I N+++ + G T +W L++L P VQ+++ EE V+ Sbjct: 295 D-----GVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLD 349 Query: 353 RSRRPRLSDR-SHLPYMEAFILETFR-----HSSF--------VP---FTIPHS-----T 390 ++ D +P + I ET R HS F VP + IP + Sbjct: 350 GGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVS 409 Query: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIF 450 T L+ Y P +++W N+D + E + F GAI K +S + F Sbjct: 410 PGYTHLRDEYFPNAHQFNIHRW--NNDSASSYSVGEEVDYGF----GAISKGVSSPYLPF 463 Query: 451 GMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKV 488 G G+ +CIGE A ++ + ++I ++ +++ P G V Sbjct: 464 GGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTV 501 >2WX2-A nrPDB Length = 473 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 100/468 (21%), Positives = 192/468 (41%), Gaps = 61/468 (13%) Query: 29 SRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQY-GDVLQIRIGSTPVVVLS 87 +RP P P P P +GH++ GKNP + R + V I IG V ++ Sbjct: 13 TRPTDP-----PVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVG 67 Query: 88 GLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGL-KSFS 146 + + + R ++YT G+ ++++ P R +L N L + + Sbjct: 68 DPHEHSRFFSPRNEILSPR-EVYTIMTPVFGEGVAYA---APYPRMREQL--NFLAEELT 121 Query: 147 IAS----DPA--SSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICA 200 IA PA ++ E+ KE E +I+ L++ A + N C Sbjct: 122 IAKFQNFVPAIQHEVRKFMAEN-WKEDEGVINLLEDCGA-------------MIINTACQ 167 Query: 201 ICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPAD-FIPILRYLPNPSLNAFKDLNEKFY 259 FG + ++ L+ + ++ S PA F+P L LP P ++ + Sbjct: 168 CLFG----EDLRKRLNARHFAQLLSKMESSLIPAAVFMPWLLRLPLPQSARCREARAELQ 223 Query: 260 SFMQKMV--KEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGA 317 + +++ +E + + + D+ L++ ++S ++ +++ A Sbjct: 224 KILGEIIVAREKEEASKDNNTSDLLGGLLKAVYRD------GTRMSLHEVCGMIVAAMFA 277 Query: 318 GFDTVTTAISWSLMYLVMNPRVQR---KIQEELDTVIGRSRRPRLSDRSHLPYMEAFILE 374 G T T SWS+++L M+P+ ++ K+ +E+D + + D +P+ E + E Sbjct: 278 GQHTSTITTSWSMLHL-MHPKNKKWLDKLHKEIDEFPAQLNYDNVMD--EMPFAERCVRE 334 Query: 375 TFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 434 + R + + + + + +PKG + + +HD++ + NP + PER Sbjct: 335 SIRRDPPL-LMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEK 393 Query: 435 PDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSV 482 DGA I FG G KCIG+ A +V LA + +F + Sbjct: 394 VDGAF--------IGFGAGVHKCIGQKFALLQVKTILATAFREYDFQL 433 >5FSA-A nrPDB Length = 490 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 106/504 (21%), Positives = 189/504 (37%), Gaps = 102/504 (20%) Query: 38 KNPPGPWGW-PLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQAL 96 K PP + W P G + G+ P+ Q+YGDV + + V G Sbjct: 4 KTPPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGP------- 56 Query: 97 VRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAA--------RRRLAQNGLKSFSIA 148 KG ++ L ++ + PV+ R + Q F++ Sbjct: 57 -------KGHEFVFNAKLSDVSAEEAYKHLTTPVFGTGVIYDCPNSRLMEQKKFAKFALT 109 Query: 149 SDPASSTSCYLEEHVSKEAEVLIS--------TLQELMAGPGHFNPYR--YVVVSVTNVI 198 +D + +V K E +++ L+E G + + + + + + Sbjct: 110 TDS-------FKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSL 162 Query: 199 CAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKF 258 R +D + +L S +L+ F P +F+ PN L + + Sbjct: 163 FGDEMRRIFDRSFAQLYS--DLDKGF-------TPINFV-----FPNLPLPHYWRRDAAQ 208 Query: 259 YSFMQKMVKEHYKTFEKGHI---RDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLF 315 +KE E+G I RD+ DSL+ H K V+++D++I N+++ + Sbjct: 209 KKISATYMKEIKLRRERGDIDPNRDLIDSLLIHSTYKD-----GVKMTDQEIANLLIGIL 263 Query: 316 GAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVI----GRSRRPRLSDRSHLPYMEAF 371 G T + +W L++L P +Q I +E+ ++ G D LP + Sbjct: 264 MGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNT 323 Query: 372 ILETFR-----HSSFV----PFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWV 422 I ET R HS F P IP + + +PKG V V+ + ++ + Sbjct: 324 IKETLRMHMPLHSIFRKVTNPLRIPETN--------YIVPKGHYVLVSPGYAHTSERYFD 375 Query: 423 NPSEFLPERFLTPD------------------GAIDKVLSEKVIIFGMGKRKCIGETIAR 464 NP +F P R+ T G + K +S + FG G+ +CIGE A Sbjct: 376 NPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAY 435 Query: 465 WEVFLFLAILLQRVEFSVPLGVKV 488 ++ L + + +++ G KV Sbjct: 436 VQLGTILTTFVYNLRWTID-GYKV 458 >3L4D-A nrPDB Length = 453 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 84/443 (18%), Positives = 178/443 (40%), Gaps = 42/443 (9%) Query: 47 PLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGR 106 P +GH++ GK+P + + ++YG + + I + V+ + + + + R Sbjct: 13 PFVGHIIQFGKDPLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQHSKFFTPRNEILSPR 72 Query: 107 PDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGL-KSFSIASDPASSTSCYLEEHVSK 165 ++Y+F + G+ ++++ P R +L N L + ++A + S Sbjct: 73 -EVYSFMVPVFGEGVAYA---APYPRMREQL--NFLAEELTVAK--------FQNFAPSI 118 Query: 166 EAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFG 225 + EV G N + N C FG + ++ L Sbjct: 119 QHEVRKFMKANWNKDEGEINILDDCSAMIINTACQCLFG----EDLRKRLDARQFAQLLA 174 Query: 226 EVVGSGNPAD-FIPILRYLPNPSLNAFKDLNEKFYSFMQKMV--KEHYKTFEKGHIRDIT 282 ++ PA F+P + LP P +D + + +++ +E + + + D+ Sbjct: 175 KMESCLIPAAVFLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEEAQKDTNTSDLL 234 Query: 283 DSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQR- 341 L+ ++S ++ +++ AG T T +WSL++L M+PR +R Sbjct: 235 AGLLGAVYRD------GTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHL-MDPRNKRH 287 Query: 342 --KIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGF 399 K+ +E+D + + + +P+ E E+ R + + + + + Sbjct: 288 LAKLHQEIDEFPAQLNYDNVME--EMPFAEQCARESIRRDPPLVMLM-RKVLKPVQVGKY 344 Query: 400 YIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIG 459 +P+G + + + D++ + NP E+ PER + K++ FG G KCIG Sbjct: 345 VVPEGDIIACSPLLSHQDEEAFPNPREWNPERNM-------KLVDGAFCGFGAGVHKCIG 397 Query: 460 ETIARWEVFLFLAILLQRVEFSV 482 E +V LA +L+ +F + Sbjct: 398 EKFGLLQVKTVLATVLRDYDFEL 420 >5JLC-A nrPDB Length = 515 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 62/278 (22%), Positives = 120/278 (43%), Gaps = 46/278 (16%) Query: 236 FIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTF-----EKGHI--RDITDSLIEH 288 F PI PN L ++ + Q+ + Y + EK I RD+ D L+++ Sbjct: 218 FTPINFVFPNLPLEHYRKRDHA-----QQAISGTYMSLIKERREKNDIQNRDLIDELMKN 272 Query: 289 CQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKI-QEEL 347 K +++D++I N+++ + G T +W L++L P VQ ++ QE++ Sbjct: 273 STYKD-----GTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQEQM 327 Query: 348 DTVIGRSRRPRLSDRSHLPYMEAFILETFR-----HSSFVPFTIPHSTTRDTSL--KGFY 400 + ++ D ++P + I ET R HS F RD ++ + Sbjct: 328 RVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLF------RKVMRDVAIPNTSYV 381 Query: 401 IPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPD---------------GAIDKVLSE 445 +P+ V V+ + ++ + P+EF R+ GAI K +S Sbjct: 382 VPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVSS 441 Query: 446 KVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483 + FG G+ +CIGE A ++ + ++I ++ +++ P Sbjct: 442 PYLPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYP 479 >3MDV-A nrPDB Length = 456 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 49/184 (26%), Positives = 87/184 (47%), Gaps = 9/184 (4%) Query: 304 DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 363 DE +++ + F AG +T +++++M L P + ++Q E+D VIG R D Sbjct: 241 DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLG 300 Query: 364 HLPYMEAFILETFR--HSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLW 421 L Y+ + E+ R ++ F + +T + G +P + + + + + Sbjct: 301 RLQYLSQVLKESLRLYPPAWGTFRLLEE---ETLIDGVRVPGNTPLLFSTYVMGRMDTYF 357 Query: 422 VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFS 481 +P F P+RF GA + F +G R CIG+ A+ EV + +A LLQR+EF Sbjct: 358 EDPLTFNPDRF--GPGAPKPRFT--YFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR 413 Query: 482 VPLG 485 + G Sbjct: 414 LVPG 417 >3S79-A nrPDB Length = 503 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 59/234 (25%), Positives = 102/234 (43%), Gaps = 43/234 (18%) Query: 270 YKTFEKG--HIRDITDSLIEH-----CQEKQLDENANV-----------QLSDEKIINIV 311 YK +EK ++D + LI E++L+E + L+ E + + Sbjct: 241 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI 300 Query: 312 LDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAF 371 L++ A DT++ ++ + L + +P V+ I +E+ TVIG R ++ D L ME F Sbjct: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQKLKVMENF 359 Query: 372 ILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEF---- 427 I E+ R+ V + D + G+ + KG + +N ++ H + + P+EF Sbjct: 360 IYESMRYQPVVDLVM-RKALEDDVIDGYPVKKGTNIILNIGRM-HRLEFFPKPNEFTLEN 417 Query: 428 ----LPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477 +P R+ P FG G R C G+ IA + L LL+R Sbjct: 418 FAKNVPYRYFQP--------------FGFGPRGCAGKYIAMVMMKAILVTLLRR 457 >3N9Z-A nrPDB Length = 487 Score = 65.1 bits (157), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 48/184 (26%), Positives = 86/184 (46%), Gaps = 6/184 (3%) Query: 298 ANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRP 357 + ++S E I V ++ G DT + + W L + N +VQ ++ E+ +++ Sbjct: 267 GDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGD 326 Query: 358 RLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHD 417 + +P ++A I ET R + T+ D L+ + IP V V + + + Sbjct: 327 MATMLQLVPLLKASIKETLRLHP-ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGRE 385 Query: 418 QKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ- 476 + +P F P R+L+ D I + + FG G R+C+G IA E+ +FL +L+ Sbjct: 386 PTFFFDPENFDPTRWLSKDKNITYF---RNLGFGWGVRQCLGRRIAELEMTIFLINMLEN 442 Query: 477 -RVE 479 RVE Sbjct: 443 FRVE 446 >3MZS-A nrPDB Length = 486 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 51/198 (25%), Positives = 91/198 (45%), Gaps = 14/198 (7%) Query: 305 EKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSH 364 E + + ++ G +T + + W L + + VQ ++EE + +RR D S Sbjct: 275 EDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREE----VLNARRQAEGDISK 330 Query: 365 L----PYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 420 + P ++A I ET R + T+ D L+ + IP V V + + D Sbjct: 331 MLQMVPLLKASIKETLRLHP-ISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAF 389 Query: 421 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 480 + +P +F P R+L+ D ++ + + FG G R+C+G IA E+ LFL +L+ F Sbjct: 390 FSSPDKFDPTRWLSKD---KDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILE--NF 444 Query: 481 SVPLGVKVDMTPIYGLTM 498 V + D+ I+ L + Sbjct: 445 KVEMQHIGDVDTIFNLIL 462 >2W0A-A nrPDB Length = 455 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 92/440 (20%), Positives = 174/440 (39%), Gaps = 44/440 (10%) Query: 50 GHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDL 109 GH+ +P + R+ + GDV ++ VV+LSG + R GDD + Sbjct: 17 GHLEEFRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSG-SHANEFFFRAGDDDLDQAKA 75 Query: 110 YTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEV 169 Y F G+++ F D+ P R+ + N ++ + + +E+ V + Sbjct: 76 YPFMTPIFGEAVVF--DASP--ERRKEMLHNA----ALRGEQMKGHAATIEDQVRR---- 123 Query: 170 LISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFG---- 225 +I+ E AG + + T+ C I G+++ L+ F Sbjct: 124 MIADWGE--AGEIDLLDFFAELTIYTSSACLI--GKKFRDQ---------LDGRFAKLYH 170 Query: 226 EVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKT--FEKGHIRDITD 283 E+ +P ++ YLP S + + + ++ +K RD+ D Sbjct: 171 ELERGTDPLAYVDP--YLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSD-RDMLD 227 Query: 284 SLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKI 343 LI E + S ++I + + + AG T + SW+L+ L+ + + Sbjct: 228 VLI-----AVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAV 282 Query: 344 QEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR-DTSLKGFYIP 402 +ELD + G R +P +E + ET R P I + + ++G I Sbjct: 283 IDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHP--PLIILMRVAKGEFEVQGHRIH 340 Query: 403 KGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETI 462 +G V + N + + +P +F+P R+ P D + I FG G+ +C+G Sbjct: 341 EGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQE-DLLNRWTWIPFGAGRHRCVGAAF 399 Query: 463 ARWEVFLFLAILLQRVEFSV 482 A ++ ++LL+ EF + Sbjct: 400 AIMQIKAIFSVLLREYEFEM 419 >5M0P-A nrPDB Length = 428 Score = 61.2 bits (147), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 47/171 (27%), Positives = 76/171 (44%), Gaps = 21/171 (12%) Query: 326 ISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFT 385 +S+ L + NP + KI+ E D Y F E R+ FVPF Sbjct: 260 VSFGLHAMNENPITREKIKSEPD------------------YAYKFAQEVRRYYPFVPF- 300 Query: 386 IPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSE 445 +P D +G IP G + ++ + HD+ LW +P+EF PERF T DG+ ++ + Sbjct: 301 LPGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRPERFETWDGSPFDLIPQ 360 Query: 446 KVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP-LGVKVDMTPIYG 495 + R C GE I + + +++ + VP ++VD+ I G Sbjct: 361 GGGDYWTNHR-CAGEWITVIIMEETMKYFAEKITYDVPEQDLEVDLNSIPG 410 >6M7X-A nrPDB Length = 484 Score = 58.5 bits (140), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 44/162 (27%), Positives = 73/162 (45%), Gaps = 6/162 (3%) Query: 299 NVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKI-QEELDTVIGRSRRP 357 N +LS + I ++L DT + +L L NP VQ+ + QE L S P Sbjct: 273 NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHP 332 Query: 358 RLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHD 417 + + + LP + A + ET R V + + D L+ ++IP G V V + + + Sbjct: 333 QKAT-TELPLLRAALKETLRLYP-VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRN 390 Query: 418 QKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIG 459 L+ P + P+R+L G+ + FG G R+C+G Sbjct: 391 PALFPRPERYNPQRWLDIRGSGRNFYH---VPFGFGMRQCLG 429 >3ABB-A nrPDB Length = 408 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 57/237 (24%), Positives = 97/237 (40%), Gaps = 42/237 (17%) Query: 257 KFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFG 316 + Y+++ +V E D L++ +QL+E L ++++ I L L Sbjct: 194 ELYTYLHGLVGRKQAEPE--------DGLLDELIARQLEEG---DLDHDEVVMIALVLLV 242 Query: 317 AGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETF 376 AG +T AI+ + L+ +P E++D ++ R P + + E Sbjct: 243 AGHETTVNAIALGALTLIQHP-------EQIDVLL---RDPG--------AVSGVVEELL 284 Query: 377 RHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPD 436 R +S V I D + G I G V V+ +N D K + NP F R Sbjct: 285 RFTS-VSDHIVRMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFDARRN---- 339 Query: 437 GAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPI 493 + + FG G +C+G+ +AR E+ + L L R+ + L V +D PI Sbjct: 340 -------ARHHVGFGHGIHQCLGQNLARAELEIALGGLFARIP-GLRLAVPLDEVPI 388 >2Y5N-A nrPDB Length = 417 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 60/279 (21%), Positives = 120/279 (43%), Gaps = 61/279 (21%) Query: 226 EVVGSGNPADFIPI------------LRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTF 273 ++ +G PAD + + L +P+ + F + F S + +E + Sbjct: 144 QMAATGQPADLVAMFARQLPVRVICELLGVPSADHDRFTRWSGAFLSTAEVTAEEMQEAA 203 Query: 274 EKGHI----------RDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVT 323 E+ + ++ TD L+ + + +++ LS+++++++ + L AG+++ T Sbjct: 204 EQAYAYMGDLIDRRRKEPTDDLVSALVQARDQQDS---LSEQELLDLAIGLLVAGYESTT 260 Query: 324 TAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVP 383 T I+ + L+ P ++R++ LD RP L + + + E R +VP Sbjct: 261 TQIADFVYLLMTRPELRRQL---LD-------RPEL--------IPSAVEELTR---WVP 299 Query: 384 FTI----PHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAI 439 + P D +L+G I G V + N DQ + + +R TP+ Sbjct: 300 LGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDR--TPN--- 354 Query: 440 DKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 + + FG G C+G +AR E+ + L +LLQR+ Sbjct: 355 ------QHLGFGHGVHHCLGAPLARVELQVALEVLLQRL 387 >5YSW-A nrPDB Length = 441 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 65/241 (26%), Positives = 99/241 (41%), Gaps = 45/241 (18%) Query: 246 PSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDE 305 P A K+ + +FMQ +V + + G DI LI H A+ L+D+ Sbjct: 218 PVAEAVKNAD-ALRAFMQALVTDK-RANPAG---DIISGLIHHA-------GADPALTDD 265 Query: 306 KIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHL 365 ++INI L AG+DT + + + L+ P +L T+ R R++D Sbjct: 266 ELINIANLLLIAGYDTTASMLGLGIFVLLQRP-------AQLATL--RDDPSRIAD---- 312 Query: 366 PYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPS 425 + E R+ S V I D G +IP G V V+ N D + W +P Sbjct: 313 -----AVEELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDPD 367 Query: 426 EFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR---VEFSV 482 L P G + FG G +C+G+ +AR E+ A LL+R V +V Sbjct: 368 LDL----TRPRG--------PHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAV 415 Query: 483 P 483 P Sbjct: 416 P 416 >6FYJ-A nrPDB Length = 421 Score = 55.8 bits (133), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 33/117 (28%), Positives = 57/117 (48%), Gaps = 2/117 (1%) Query: 367 YMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSE 426 Y + F+ E R F PF + +D + KG+ +G ++ + NHD ++W NP Sbjct: 279 YSQMFVQEVRRFYPFFPFVVA-LVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDV 337 Query: 427 FLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483 F P+RF +G+ + + + MG R C GE + + + L L R+++ VP Sbjct: 338 FSPDRFAKWEGSPFSFIPQGGGDYFMGHR-CAGEWVTIEVMKVSLDYLTNRMDYEVP 393 >4ZGX-A nrPDB Length = 489 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 44/162 (27%), Positives = 72/162 (44%), Gaps = 6/162 (3%) Query: 299 NVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKI-QEELDTVIGRSRRP 357 +LS E I ++L DT + +L L NP VQ+ + QE L S P Sbjct: 273 KAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHP 332 Query: 358 RLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHD 417 + + + LP + A + ET R V + + D L+ ++IP G V V + + + Sbjct: 333 QKAT-TELPLLRAALKETLRLYP-VGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRN 390 Query: 418 QKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIG 459 L+ P + P+R+L G+ + FG G R+C+G Sbjct: 391 AALFPRPERYNPQRWLDIRGSGRNF---HHVPFGFGMRQCLG 429 >6CR2-A nrPDB Length = 477 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 98/486 (20%), Positives = 178/486 (36%), Gaps = 80/486 (16%) Query: 38 KNPPGPWGW-PLIGHMLTLGKNPHLALSRMSQQYGDVLQ-IRIGSTPVVVLSGLDTIRQA 95 K PP + W P IG ++ G +P+ +YGD+ I +G V L Sbjct: 4 KTPPVVFHWFPFIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLG-------- 55 Query: 96 LVRQGDDFKGRPDLYTFTLISNGQ------SMSFSPDSGPVWAAR--------RRLAQNG 141 +G+DF I NG+ +SP + PV+ + + Q Sbjct: 56 --TKGNDF-----------ILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKK 102 Query: 142 LKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYV----VVSVTNV 197 + + SD S ++ E E + G F+ + + + + + Sbjct: 103 FVKYGLTSDALRSYVPL----ITDEVESFVKNSPAFQGHKGVFDVCKTIAEITIYTASRS 158 Query: 198 ICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEK 257 + ++D EL NL+ F P +F+ L + P P K Sbjct: 159 LQGKEVRSKFDSTFAELYH--NLDMGFA-------PINFM--LPWAPLPHNRKRDAAQRK 207 Query: 258 FYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGA 317 +++K + K D+ +L+ C K + DE+I ++++ L A Sbjct: 208 LTETYMEIIKARRQAGSKKDSEDMVWNLMS-CVYKN-----GTPVPDEEIAHMMIALLMA 261 Query: 318 GFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDR-SHLPYMEAFILETF 376 G + ++ SW ++ L P + ++ +E V+G P D L I ET Sbjct: 262 GQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLHAKVIKETL 321 Query: 377 RHSSFVPFTIPHSTTRDTSLKG--FYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERF-- 432 R + + +I + ++ G + IP V + ++ + NP E+ P R+ Sbjct: 322 RLHAPI-HSIIRAVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWNPHRWDE 380 Query: 433 -----LTPD-------GAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 480 D G + K + + FG G+ +CIGE A ++ A+L++ F Sbjct: 381 NIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFRF 440 Query: 481 SVPLGV 486 GV Sbjct: 441 RNLPGV 446 >3AWQ-A nrPDB Length = 415 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 35/126 (27%), Positives = 53/126 (42%), Gaps = 20/126 (15%) Query: 367 YMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSE 426 Y E F+ E R F P + ++ +D +G P+GR V ++ + NHD W +P E Sbjct: 273 YAELFVQEVRRFYPFFPAVVARAS-QDFEWEGMAFPEGRQVVLDLYGSNHDAATWADPQE 331 Query: 427 FLPERF---------LTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477 F PERF P G D L +C GE I + + +L+ Sbjct: 332 FRPERFRAWDEDSFNFIPQGGGDHYLGH----------RCPGEWIVLAIMKVAAHLLVNA 381 Query: 478 VEFSVP 483 + + VP Sbjct: 382 MRYDVP 387 >3NC3-A nrPDB Length = 441 Score = 52.8 bits (125), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 48/185 (25%), Positives = 81/185 (43%), Gaps = 24/185 (12%) Query: 296 ENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSR 355 E + LSD+ I+ ++L++ A + ++ + +L+ NP E+++ V Sbjct: 248 EYEGMALSDKDILALILNVLLAATEPADKTLALMIYHLLNNP-------EQMNDV----- 295 Query: 356 RPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIN 415 L+DRS +P I ET R+ V IP ++DT + G I K VF N Sbjct: 296 ---LADRSLVPRA---IAETLRYKPPVQL-IPRQLSQDTVVGGMEIKKDTIVFCMIGAAN 348 Query: 416 HDQKLWVNPSEFLPERFLTPDGAIDKVLS--EKVIIFGMGKRKCIGETIARWEVFLFLAI 473 D + + P F R D I S + + FG G C+G A+ E+ + I Sbjct: 349 RDPEAFEQPDVFNIHR---EDLGIKSAFSGAARHLAFGSGIHNCVGTAFAKNEIEIVANI 405 Query: 474 LLQRV 478 +L ++ Sbjct: 406 VLDKM 410 >5LIE-A nrPDB Length = 414 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 61/267 (22%), Positives = 102/267 (38%), Gaps = 44/267 (16%) Query: 246 PSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDE 305 P LN +D + Y++ +++ G + D ++ +D+ LSD Sbjct: 191 PRLNV-EDAGSRLYTYALELIA--------GKRAEPADDMLSVVANATIDDPDAPALSDA 241 Query: 306 KIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHL 365 ++ LF AG +T +I+ L+ L NP ++L T+ RS Sbjct: 242 ELYLFFHLLFSAGAETTRNSIAGGLLALAENP-------DQLQTL-----------RSDF 283 Query: 366 PYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPS 425 + I E R +S P + + +R SL G I G+ V V + N D ++ Sbjct: 284 ELLPTAIEEIVRWTSPSP-SKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRAD 342 Query: 426 EFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLG 485 EF R P + FG G C+G +AR E+ + LL R Sbjct: 343 EFDITRKPNPH-----------LGFGQGVHYCLGANLARLELRVLFEELLSRFG-----S 386 Query: 486 VKVDMTPIYGLTMKHACCEHFQMQLRS 512 V+V + + +H H ++LR Sbjct: 387 VRVVEPAEWTRSNRHTGIRHLVVELRG 413 >2ZBZ-A nrPDB Length = 412 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 58/271 (21%), Positives = 106/271 (39%), Gaps = 48/271 (17%) Query: 226 EVVGSGNPADFIPILRYLPNPSLNAFKDLNEKF--YSFMQKMVKEHYKTFE-------KG 276 E++ +G AD + LP PS+ + L + + F Q K ++ + + Sbjct: 136 EMLAAGPTADLVSQF-ALPVPSMVICRLLGVPYADHEFFQDASKRLVQSTDAQSALTARN 194 Query: 277 HIRDITDSLIEHCQEKQ---------LDENANVQLSDEKIINIVLDLFGAGFDTVTTAIS 327 + D LI Q + D+ AN ++ E++I+ + L AG +T + S Sbjct: 195 DLAGYLDGLITQFQTEPGAGLVGALVADQLANGEIDREELISTAMLLLIAGHETTASMTS 254 Query: 328 WSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIP 387 S++ L+ +P ++ +DRS +P + E R+ + Sbjct: 255 LSVITLLDHPEQYAALR---------------ADRSLVP---GAVEELLRYLAIADIAGG 296 Query: 388 HSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKV 447 T D ++G I G V V N D ++ +P R + Sbjct: 297 RVATADIEVEGQLIRAGEGVIVVNSIANRDGTVYEDPDALDIHRS-----------ARHH 345 Query: 448 IIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 + FG G +C+G+ +AR E+ + L L+ RV Sbjct: 346 LAFGFGVHQCLGQNLARLELEVILNALMDRV 376 >6F0B-A nrPDB Length = 395 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 43/196 (21%), Positives = 75/196 (38%), Gaps = 32/196 (16%) Query: 283 DSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRK 342 DSLI E QL+ + I ++L L G+DT + IS SL+ + P Sbjct: 202 DSLIRRLVTGPYQEK---QLTFHETIGVILMLIVGGYDTTASTISLSLVSYALQPEKFSV 258 Query: 343 IQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIP 402 + E H + + E R+ + + T D + G + Sbjct: 259 VHE------------------HPERIPLLVEELLRYHTVSQLGLGRIATEDVEVGGVTVR 300 Query: 403 KGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETI 462 G+ V N D+ ++ NP E +R P + FG G +C+G+ + Sbjct: 301 AGQMVVAALPLANRDESVFPNPDELDFDRPSVPH-----------VGFGYGPHQCVGQAL 349 Query: 463 ARWEVFLFLAILLQRV 478 AR E+ + +++R+ Sbjct: 350 ARVELQEAIPAVIRRL 365 >2ZQJ-A nrPDB Length = 417 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 43/159 (27%), Positives = 68/159 (42%), Gaps = 15/159 (9%) Query: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPF 384 AIS+ L++ + K +E L + R R E F+ E R+ F PF Sbjct: 246 AISYFLVFSALALHEHPKYKEWLRSGNSRER-------------EMFVQEVRRYYPFGPF 292 Query: 385 TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLS 444 + +D KG V ++ + NHD +LW +P EF PERF + + ++ Sbjct: 293 -LGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFRPERFAEREENLFDMIP 351 Query: 445 EKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483 + G R C GE I + L L+ ++E+ VP Sbjct: 352 QGGGHAEKGHR-CPGEGITIEVMKASLDFLVHQIEYDVP 389 >4GGV-A nrPDB Length = 418 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 51/230 (22%), Positives = 88/230 (38%), Gaps = 46/230 (20%) Query: 252 KDLNEKFYSFMQKMVKEHYKTFEKGHI----RDITDSLIEHCQEKQLDENANVQLSDEKI 307 +D E+ + M GH+ R + L+ H + ++D +L+D +I Sbjct: 200 RDATERLRPLLDYMA---------GHVTERRRTPREDLLTHLVQAEVDGE---RLTDNEI 247 Query: 308 INIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPY 367 +N+ L G T T + +++ L +P V K++ +DRS +P Sbjct: 248 VNVANILLVTGHITTTMTLGNTVLCLDADPEVAAKVR---------------ADRSLVPG 292 Query: 368 MEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEF 427 L S+ + T+R+ + G IPK + V + N D + + +P + Sbjct: 293 AIEEALRVLSPSA----ALARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVY 348 Query: 428 LPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477 P R P FG G C+G +AR E + L L R Sbjct: 349 DPTRDPNPHFG-----------FGRGIHFCLGAPLARLEGRVALNALFDR 387 >2FR7-A nrPDB Length = 412 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 57/247 (23%), Positives = 96/247 (38%), Gaps = 36/247 (14%) Query: 248 LNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKI 307 NAF NE S +++ E+ ++ C D +++ E+ Sbjct: 185 FNAFGPPNELRQSAIERSAPHQAYVAEQCQRPNLAPGGFGACIHAFSDTG---EITPEEA 241 Query: 308 INIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPY 367 +V L AG DT I+ ++ L P +++ + P L+ + + Sbjct: 242 PLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRAD----------PSLARNA---F 288 Query: 368 MEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEF 427 EA E+ + F +TTRD L G I +G V + N D + W +P + Sbjct: 289 EEAVRFESPVQTFF------RTTTRDVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRY 342 Query: 428 LPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV---EFSVPL 484 I + S V FG G C+G+ +AR E + LA L ++V E + PL Sbjct: 343 ----------DITRKTSGHV-GFGSGVHMCVGQLVARLEGEVVLAALARKVAAIEIAGPL 391 Query: 485 GVKVDMT 491 + + T Sbjct: 392 KRRFNNT 398 >2X2N-A nrPDB Length = 475 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 38/183 (20%), Positives = 79/183 (43%), Gaps = 13/183 (7%) Query: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQ--RKIQEELDTVIGRSRRPRL 359 +S ++ +++ AG T + +WS+++L+ V+ +++E++ + + Sbjct: 262 MSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFPAQLNYNNV 321 Query: 360 SDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 419 D +P+ E E+ R + + D + + +PKG + + +HD++ Sbjct: 322 MD--EMPFAERCARESIRRDPPL-LMLMRKVMADVKVGSYVVPKGDIIACSPLLSHHDEE 378 Query: 420 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 + P + PER +GA I FG G KCIG+ +V LA + + Sbjct: 379 AFPEPRRWDPERDEKVEGAF--------IGFGAGVHKCIGQKFGLLQVKTILATAFRSYD 430 Query: 480 FSV 482 F + Sbjct: 431 FQL 433 >5VWS-A nrPDB Length = 393 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 58/240 (24%), Positives = 93/240 (38%), Gaps = 47/240 (19%) Query: 280 DITDSLIEHCQEKQLDENANV------------QLSDEKIINIVLDLFGAGFDTVTTAIS 327 ++ D L EHC+ ++ ++ +L E+++N L AG T T I Sbjct: 184 EMNDYLREHCRSRRTHPRDDLLTRLVQAEVEGKRLDLEEVVNTASLLLLAGHLTTTVLIG 243 Query: 328 WSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPF-TI 386 +++ L +P ++ ++ +D S +P A + E+ R S PF Sbjct: 244 NTMLCLWDHPEAEKAVR---------------ADPSLIP---AALEESLRLRS--PFLQA 283 Query: 387 PHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEK 446 TTRD ++ G IP R V NHD + + +P F R T Sbjct: 284 GRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFDLHRQTT-----------G 332 Query: 447 VIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPL---GVKVDMTPIYGLTMKHACC 503 I FG G C+G + R E + L LL R P G+ + I+G + C Sbjct: 333 HIAFGHGVHFCLGAQLGRLEGRIALERLLGRFTEIHPWPREGISFYQSAIFGASRMPVRC 392 >6G5O-A nrPDB Length = 399 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 41/179 (22%), Positives = 77/179 (43%), Gaps = 32/179 (17%) Query: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360 +L+ E++ +++ F G DTV A++ S+ YL +P ++++E P ++ Sbjct: 204 KLTKEEVKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRKE----------PEIT 253 Query: 361 DRSHLPYMEAFILETFRHSSFVPFT-IPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 419 R+ + E R+ F P T + T DT + + + + N D Sbjct: 254 GRA--------VEEMIRY--FSPLTQMGRVVTEDTHVCEHAVKADSRISLCWASANRDAA 303 Query: 420 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 ++ NP+E + +R + P + FG C+G T AR + + L L Q+V Sbjct: 304 VFENPNEIVLDRKVNPH-----------VGFGFSHHNCLGATHARQILKILLQTLAQKV 351 >1EHE-A nrPDB Length = 403 Score = 48.1 bits (113), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 44/198 (22%), Positives = 78/198 (39%), Gaps = 33/198 (16%) Query: 299 NVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPR 358 N+ SD + I L AG T+ I+ + L +P D + P Sbjct: 223 NIDKSD--AVQIAFLLLVAGNATMVNMIALGVATLAQHP----------DQLAQLKANPS 270 Query: 359 LSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQ 418 L+ + F+ E R+ + I + D + + + + N D+ Sbjct: 271 LAPQ--------FVEELCRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDE 322 Query: 419 KLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR- 477 +++ NP EF R P + FG G +CI E +A+ E+ + L Q+ Sbjct: 323 EVFENPDEFNMNRKWPPQDPLG---------FGFGDHRCIAEHLAKAELTTVFSTLYQKF 373 Query: 478 --VEFSVPLGVKVDMTPI 493 ++ +VPLG K++ TP+ Sbjct: 374 PDLKVAVPLG-KINYTPL 390 >4OQR-A nrPDB Length = 457 Score = 48.1 bits (113), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 44/180 (24%), Positives = 75/180 (41%), Gaps = 34/180 (18%) Query: 299 NVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPR 358 + L+DE++ NI L L AG +T + L+ +P E++ Sbjct: 261 DTDLTDEELTNIALILLVAGHETTANMLGLGTFALLQHP-------EQI----------- 302 Query: 359 LSDRSHLPYMEAFILETFRHSSFVPFTIPH-STTRDTSLKGFYIPKGRCVFVNQWQINHD 417 ++L +A + E R+ S V P+ + D L+G I KG V + +N D Sbjct: 303 ----ANLDSPDA-VEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRD 357 Query: 418 QKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477 K++ P +D+V + K FG G +C+G+ +AR E+ + L R Sbjct: 358 PKVFDEPDIL----------QLDRVDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFAR 407 >4Z5Q-A nrPDB Length = 423 Score = 48.1 bits (113), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 61/253 (24%), Positives = 109/253 (43%), Gaps = 46/253 (18%) Query: 231 GNPADFIPILRYLPNPSLNAFKDLNEK-FYSFM--QKMVKEHYKTFEKGHIRDITDSLIE 287 G P D LR + +L+ + +E+ SFM QK ++ K D+T +LIE Sbjct: 181 GVPEDDRTRLRGWCDAALSTGELTDEECVQSFMDLQKYFEDLVKERRAEPRDDLTSALIE 240 Query: 288 HCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEEL 347 +A+ +L++ ++I + + + GF+T + IS S ++++ R EL Sbjct: 241 A-------RDAHDRLAEPELIGLCISILIGGFETTASEIS-SFVHVLQQRR-------EL 285 Query: 348 DTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTI----PHSTTRDTSLKGFYIPK 403 T + +D +P A + E R FVPF P D ++ G + + Sbjct: 286 WTRL-------CADPEAIP---AAVEELLR---FVPFAANGISPRYALEDMTVGGVLVRE 332 Query: 404 GRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIA 463 G V V+ +N D ++ N E + +R + ++FG G C+G +A Sbjct: 333 GEPVIVDTSAVNRDGLVFDNADEVVIDR-----------ADNRHMVFGHGAHHCLGAHLA 381 Query: 464 RWEVFLFLAILLQ 476 R E+ L L++ Sbjct: 382 RVELQEALKALVE 394 >4OQS-A nrPDB Length = 433 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 44/180 (24%), Positives = 70/180 (38%), Gaps = 34/180 (18%) Query: 299 NVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPR 358 + L+DE++ NI L L AG +T + L+ +P Q + D V Sbjct: 222 DTDLTDEELTNIALLLLVAGHETTANMLGLGTFALLQHPE-QIAALDSPDAV-------- 272 Query: 359 LSDRSHLPYMEAFILETFRHSSFVPFTIPH-STTRDTSLKGFYIPKGRCVFVNQWQINHD 417 E R+ S V P+ + D L+G I KG V + +N D Sbjct: 273 --------------EELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRD 318 Query: 418 QKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477 K++ P +D+V + K FG G +C+G+ +AR E+ + L R Sbjct: 319 PKVFDEPDIL----------QLDRVDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFAR 368 >3TKT-A nrPDB Length = 450 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 35/120 (29%), Positives = 56/120 (46%), Gaps = 15/120 (12%) Query: 360 SDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 419 +DR+ LP + E R ++ V + + T DT L G I G + +N NHD Sbjct: 317 ADRNLLP---GIVEEAIRWTTPVQHFMRTAAT-DTELCGQKIAAGDWLMLNYVAANHDPA 372 Query: 420 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 + P +F P R + + + FG G +C+G +AR E+ + L +LL RV+ Sbjct: 373 QFPEPRKFDPTR-----------PANRHLAFGAGSHQCLGLHLARLEMRVLLDVLLDRVD 421 >5HDI-A nrPDB Length = 404 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 40/170 (23%), Positives = 70/170 (41%), Gaps = 31/170 (18%) Query: 310 IVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYME 369 +++ LF AG ++ + ++ L P +Q+++ R++ + Sbjct: 237 MMVTLFAAGGESTAALLGSAVWILATRPDIQQQV------------------RANPELLG 278 Query: 370 AFILETFRHSSFVPFTIPHSTTRD-TSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFL 428 AFI ET R+ PF + R+ T+L G +P + + N D + P EF Sbjct: 279 AFIEETLRYEP--PFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEF- 335 Query: 429 PERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 +D+ + I FG G C+G +AR E + L +LL R Sbjct: 336 ---------RLDRAGGKGHISFGKGAHFCVGAALARLEARIVLRLLLDRT 376 >4RM4-A nrPDB Length = 396 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 64/246 (26%), Positives = 92/246 (37%), Gaps = 50/246 (20%) Query: 256 EKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLF 315 E+ +F +++E E+ DI L+E E +LS E++I L Sbjct: 189 EELAAFFAGIIEEKRNKPEQ----DIISILVEA-------EETGEKLSGEELIPFCTLLL 237 Query: 316 GAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILET 375 AG +T T IS ++ ++ P V EEL RSH M + E Sbjct: 238 VAGNETTTNLISNAMYSILETPGVY----EEL--------------RSHPELMPQAVEEA 279 Query: 376 FRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTP 435 R + P + RDT + G I +G V N D+ + P F R P Sbjct: 280 LRFRAPAP-VLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRRHPNP 338 Query: 436 DGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTP--- 492 I FG G C+G +AR E + L L+ + P V +TP Sbjct: 339 H-----------IAFGHGIHFCLGAPLARLEANIALTSLIS----AFPHMECVSITPIEN 383 Query: 493 --IYGL 496 IYGL Sbjct: 384 SVIYGL 389 >3EJB-B nrPDB Length = 404 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 44/178 (24%), Positives = 75/178 (42%), Gaps = 30/178 (16%) Query: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360 +L++E+ + + L AG +T IS S++ L+ +P K++E D +IG + Sbjct: 218 KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPD-LIGTA------ 270 Query: 361 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 420 + E R+ S T + D + G I +G V++ N D + Sbjct: 271 -----------VEECLRYESPTQMTA-RVASEDIDICGVTIRQGEQVYLLLGAANRDPSI 318 Query: 421 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 + NP F R P + FG G C+G ++AR E + + LLQR+ Sbjct: 319 FTNPDVFDITRSPNPH-----------LSFGHGHHVCLGSSLARLEAQIAINTLLQRM 365 >2Z36-A nrPDB Length = 413 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 61/291 (20%), Positives = 113/291 (38%), Gaps = 49/291 (16%) Query: 232 NPADFIPILRYLPNPSLNAFKDL-----NEKFYSFMQKMVKEHYKTFEK----GHIRDIT 282 P D + L LP PSL + L + F+ M+ ++ +R Sbjct: 143 RPVDLVQAL-SLPVPSLVICELLGVPYTDHDFFQSRTTMMVSRTSMEDRRRAFAELRAYI 201 Query: 283 DSLIEHCQEKQLDENANVQLSDEK---------IINIVLDLFGAGFDTVTTAISWSLMYL 333 D LI + + D+ + Q++ ++ ++++ L AG +T IS ++ L Sbjct: 202 DDLITRKESEPGDDLFSRQIARQRQEGTLDHAGLVSLAFLLLTAGHETTANMISLGVVGL 261 Query: 334 VMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRD 393 + +P E+L V R ++ + E R+ + T D Sbjct: 262 LSHP-------EQLTVVKANPGRTPMA-----------VEELLRYFTIADGVTSRLATED 303 Query: 394 TSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMG 453 + G I G V V+ N D ++ +P+ ER GA + FG G Sbjct: 304 VEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVER-----GA------RHHLAFGFG 352 Query: 454 KRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCE 504 +C+G+ +AR E+ + L +R+ S+ L V ++ P G ++ + E Sbjct: 353 PHQCLGQNLARMELQIVFDTLFRRIP-SLRLAVPMEDVPFKGDSVIYGVHE 402 >1CPT-A nrPDB Length = 428 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 47/184 (25%), Positives = 82/184 (44%), Gaps = 34/184 (18%) Query: 304 DEKIINIV-LDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDR 362 D+K IN + + AG DT +++ +++ L NP Q + + +I PRL D Sbjct: 253 DDKYINAYYVAIATAGHDTTSSSSGGAIIGLSRNPE-QLALAKSDPALI-----PRLVDE 306 Query: 363 SHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWV 422 + + T SF+ + DT ++G I +G + ++ N D++++ Sbjct: 307 A--------VRWTAPVKSFM-----RTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFS 353 Query: 423 NPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR---VE 479 NP EF RF + + FG G C+G+ +A+ E+ +F LL + VE Sbjct: 354 NPDEFDITRF-----------PNRHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLKSVE 402 Query: 480 FSVP 483 S P Sbjct: 403 LSGP 406 >5XW2-A nrPDB Length = 419 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 68/287 (23%), Positives = 109/287 (37%), Gaps = 51/287 (17%) Query: 212 QELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNA--FKD-LNEKFYSF----MQK 264 QELL V + F + P + L PS + F+ + E +S M+ Sbjct: 130 QELLDAVADRDTFDLMTALAYPLPVTVVAELLSIPSADRHLFEGWMTEIVHSLGDVSMED 189 Query: 265 MVKEHYKTFEKGH--IRDITDSLIEHCQEKQLDENANV------------QLSDEKIINI 310 ++ + FE G +R + + L EH E + ++ +L+D I+N Sbjct: 190 APEDQERIFEAGMAPMRKMLEYLREHAAECRRRPRGDLMGKLIEAEVDGRRLTDNHIVNF 249 Query: 311 VLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEA 370 L AG+ T T I +++ L P +++ +DRS +P Sbjct: 250 AKMLLIAGYLTTTMLIGNTVLCLDSYPEQAARVR---------------ADRSLIP---G 291 Query: 371 FILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPE 430 + E+ R S V T +TTRD + G + + V V N D + + P F Sbjct: 292 LLEESMRFLSPVAATY-RATTRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPELFDMT 350 Query: 431 RFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477 R P + FG G C+G +AR E + L LL R Sbjct: 351 RGPNPH-----------LGFGRGIHFCLGGPLARMEGRVALDHLLDR 386 >4WPZ-A nrPDB Length = 397 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 58/199 (29%), Positives = 80/199 (40%), Gaps = 47/199 (23%) Query: 297 NANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRR 356 + + L++ +II + + + AG +T IS L+ L+ NP EELD Sbjct: 212 DGDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLHNP-------EELD-------- 256 Query: 357 PRLSD-RSHLPYMEAFILETFRHSSFVPFT-----IPHSTTRDTSLKGFYI-PKGRCVFV 409 +L D R +P + E R FVP T IP TT + L G + P G V Sbjct: 257 -KLRDNREAIPKA---VDELLR---FVPLTTTGGIIPRLTTAEVELSGGQVLPAGAVVLP 309 Query: 410 NQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKV--IIFGMGKRKCIGETIARWEV 467 N D PE F DG V E + FG G C+G +AR E+ Sbjct: 310 AVATANRD-----------PEVF--EDGERLNVTRENNPHLAFGAGIHHCLGAQLARIEL 356 Query: 468 FLFLAILLQR---VEFSVP 483 L +L R V +VP Sbjct: 357 QEALGAILDRMPQVRLAVP 375 >5Y1I-A nrPDB Length = 403 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 41/204 (20%), Positives = 80/204 (39%), Gaps = 26/204 (12%) Query: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360 +++ + I + L GAG +T I+ + L+ NP ++++ D + Sbjct: 221 EITQDDAAGIGMMLLGAGHETTANMIALGTLALLENPEQLAEVRDSDDPKV--------- 271 Query: 361 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 420 + + E R+ + T+ D + G I G + N D L Sbjct: 272 -------IVNTVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDL 324 Query: 421 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 480 + P+R I + + + + FG G +C+G T+AR E+ + + LL+R+ Sbjct: 325 YPE----APDRL-----DIHRANARRHLAFGYGVHQCLGATLARVELQIVYSTLLRRIP- 374 Query: 481 SVPLGVKVDMTPIYGLTMKHACCE 504 ++ L +D P + H E Sbjct: 375 TLALAGTLDEIPFKHDQIAHGVYE 398 >4JBT-A nrPDB Length = 410 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 53/222 (23%), Positives = 87/222 (39%), Gaps = 38/222 (17%) Query: 256 EKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLF 315 ++ + + +MV+ KT E G D+T +LI + L++E++I + L Sbjct: 194 DEMHGYFTEMVRR--KTAEPGD--DLTSALIYAT-------DGETPLTEEEVIGNLQALV 242 Query: 316 GAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILET 375 AG +T + I ++ L+ +P R ++ D IG E I ET Sbjct: 243 AAGHETTVSLILTAVRALLSHPEQLRLVR---DGEIG---------------WETAIEET 284 Query: 376 FRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTP 435 R V + T D L IP+G V ++ I D + ++ Sbjct: 285 LRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVHGADAD--------- 335 Query: 436 DGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477 D I + + + I FG G C G +AR E + L L R Sbjct: 336 DFDITRATAARHISFGHGPHICPGAALARLEAAIALPALFTR 377 >6G71-A nrPDB Length = 405 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 26/82 (31%), Positives = 38/82 (46%), Gaps = 11/82 (13%) Query: 386 IPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSE 445 +P T DT L G++IP+G + + N D+ +W +P F ER SE Sbjct: 286 VPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRFDIERG-----------SE 334 Query: 446 KVIIFGMGKRKCIGETIARWEV 467 + FG G C+G AR +V Sbjct: 335 AHLAFGKGVHVCLGAWAARSQV 356 >3TYW-A nrPDB Length = 417 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 38/177 (21%), Positives = 72/177 (40%), Gaps = 29/177 (16%) Query: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSD 361 ++ E++++ + AG +T T+ I+ S + L+ P + +++++ D Sbjct: 234 VTTEQLLSTLGITINAGRETTTSMIALSTLLLLDRPELPAELRKDPDL------------ 281 Query: 362 RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLW 421 +P +L + +P + D L G +P V NHD Sbjct: 282 ---MPAAVDELLRVLSVADSIPLRV---AAEDIELSGRTVPADDGVIALLAGANHD---- 331 Query: 422 VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 PE+F P+ + FG G +C+G+ +AR E+ + L LL+RV Sbjct: 332 -------PEQFDDPERVDFHRTDNHHVAFGYGVHQCVGQHLARLELEVALETLLRRV 381 >6A7J-A nrPDB Length = 411 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 58/253 (22%), Positives = 103/253 (40%), Gaps = 59/253 (23%) Query: 251 FKDLNEKFYS-----------------FMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQ 293 K+L EKF+S K+V+E K G D+T +LI ++ Sbjct: 168 LKELFEKFFSTQTPPEEVPQMMADLGTLFTKIVEE--KKANPGD--DLTSALIAASEDGD 223 Query: 294 LDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGR 353 L+DE+I+N + + AG +T + I + L ++P ++K+ Sbjct: 224 -------HLTDEEILNTLQLIIAAGHETTISLIVNVVEALAIHPEQRKKV---------- 266 Query: 354 SRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQ 413 LS +P+ E I ET R ++ + T D + +PKG + V+ Sbjct: 267 -----LS--GEIPW-EGVIEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGA 318 Query: 414 INHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAI 473 + D++ + P+ + TP+ + I FG G C G ++R E + L Sbjct: 319 LGRDEEQY-GPTAGDFDATRTPN---------RHIAFGHGPHVCPGAALSRLEAGIALPA 368 Query: 474 LLQR---VEFSVP 483 L +R ++ +VP Sbjct: 369 LYERFPELDLAVP 381 >6B11-A nrPDB Length = 440 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 44/198 (22%), Positives = 82/198 (41%), Gaps = 36/198 (18%) Query: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSD 361 LS +++ + L AG +T + ++ S++ L+ +P R++ TV P L Sbjct: 264 LSHADVLDNAVLLLAAGHETTASMVTMSVLVLLQHPTAWREL-----TV-----NPGL-- 311 Query: 362 RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLW 421 + + E R+ S + + S T D + G I G + N D+ ++ Sbjct: 312 ------LPGAVDELLRYLS-IADGLRRSATADIEIDGHTIRAGDGLVFLLAAANRDEAVF 364 Query: 422 VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFS 481 P F R + + + FG G +C+G+ +AR E+ + L +L+R+ Sbjct: 365 SEPEAFDIHRS-----------ARRHVAFGYGPHQCLGQNLARMELEVALGAVLERLPAL 413 Query: 482 VPLGVKVDMTPIYGLTMK 499 P T + GL +K Sbjct: 414 RP------TTDVAGLRLK 425 >3OFT-A nrPDB Length = 396 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 42/158 (26%), Positives = 61/158 (38%), Gaps = 30/158 (18%) Query: 314 LFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFIL 373 LFG G DTV I ++L +P QR ++E D + P +D Sbjct: 232 LFG-GLDTVAAMIGMVALHLARHPEDQRLLRERPDLI------PAAAD------------ 272 Query: 374 ETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFL 433 E R V + + D G I KG V++ N D + P E +R L Sbjct: 273 ELMRRYPTV--AVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGL 330 Query: 434 TPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFL 471 P + G+G +C+G +AR EV +FL Sbjct: 331 AP---------IRHTTMGVGAHRCVGAGLARMEVIVFL 359 >5EX6-C nrPDB Length = 434 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 56/251 (22%), Positives = 94/251 (37%), Gaps = 53/251 (21%) Query: 255 NEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDL 314 E F ++ MV K D D LI + D ++DE++ + + + Sbjct: 223 GEAFSRYLVTMVARERK--------DPGDGLIGMVVAEHGD-----TVTDEELRGVCVQM 269 Query: 315 FGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILE 374 AG D ++ I ++ L+ NP E++ + R +P E + E Sbjct: 270 MLAGDDNISGMIGLGVLALLRNP-------EQIAAL-----------RGDVPAAERAVDE 311 Query: 375 TFRHSSFVPFT-IPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFL 433 R+ + VP+ P + D+++ I G V + N D L Sbjct: 312 LIRYLT-VPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALL------------ 358 Query: 434 TPDGAIDKVLSEKV--IIFGMGKRKCIGETIARWEVFLFLAILLQR---VEFSVPLGVKV 488 PD V E V + FG G C+G +AR E+ + L +R + + P G Sbjct: 359 -PDADRLDVTREAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLADPDGATE 417 Query: 489 --DMTPIYGLT 497 TP YG++ Sbjct: 418 FRLSTPAYGIS 428 >2X9P-A nrPDB Length = 404 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 39/178 (21%), Positives = 66/178 (37%), Gaps = 28/178 (15%) Query: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360 +L+++++ ++ + L AG D+V + + ++ L +P R L+ Sbjct: 225 ELTEDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPD---------------QRAAALA 269 Query: 361 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 420 D + +L T R V P + D G I G V + N D++ Sbjct: 270 DPDVMARAVEEVLRTARAGGSV--LPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERA 327 Query: 421 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 + P EF R P + FG G CIG +AR E+ L R+ Sbjct: 328 FTGPEEFDAARTPNPH-----------LTFGHGIWHCIGAPLARLELRTMFTKLFTRL 374 >5XJN-A nrPDB Length = 455 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 54/228 (23%), Positives = 92/228 (40%), Gaps = 46/228 (20%) Query: 257 KFYSFMQKMVKEHYKTFEKGHIRD-ITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLF 315 +++ Q+MV + + H D +T L+ QE Q +++D +I +++ L Sbjct: 243 EYWQECQRMVADAH-----AHGGDNLTADLVRAQQEGQ-------EITDHEIASLLYSLL 290 Query: 316 GAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILET 375 AG +T TT IS L+ +P + I E P+L + A + E Sbjct: 291 FAGHETTTTLISNCFRVLLDHPEQWQAILE----------NPKL--------IPAAVDEV 332 Query: 376 FRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTP 435 R+S + +DT + G I +G V + N D+ + N EF Sbjct: 333 LRYSGSI-VGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEF-------- 383 Query: 436 DGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483 I + + + + FG G C+G +A+ L I L+ V VP Sbjct: 384 --DISRANAREHLSFGFGIHYCLGNMLAK----LQAKICLEEVTRLVP 425 >6DCD-A nrPDB Length = 424 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 45/179 (25%), Positives = 75/179 (41%), Gaps = 32/179 (17%) Query: 303 SDEKIINIVLD---LFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRL 359 S ++I++V LF AG +T ++ ++ L P +QR+++E Sbjct: 235 STPEVIDVVRSATFLFAAGQETTAKLLTAAMRVLGDRPDIQRRLRE-------------- 280 Query: 360 SDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 419 +RS +P FI E+ R S V + R T++ G I G V V N D + Sbjct: 281 -NRSLIP---NFIEESLRMDSPVKSDSRLARKR-TTVGGLDIAAGTVVMVLPGAANRDPR 335 Query: 420 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 + +P EF +D+ + + F G C G +AR E + L +L R+ Sbjct: 336 RFEDPHEF----------RLDRPNVREHMAFARGVHSCPGGPLARVEGRVSLERILDRM 384 >3MGX-A nrPDB Length = 415 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 27/89 (30%), Positives = 39/89 (43%), Gaps = 11/89 (12%) Query: 390 TTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVII 449 TT D ++ G +P G V N D + +P FLP R + I Sbjct: 308 TTADVTINGRDLPSGTPVVAWLPAANRDPAEFDDPDTFLPGRK-----------PNRHIT 356 Query: 450 FGMGKRKCIGETIARWEVFLFLAILLQRV 478 FG G C+G +AR E+ + L +L +RV Sbjct: 357 FGHGMHHCLGSALARIELSVVLRVLAERV 385 >4DO1-A nrPDB Length = 410 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 49/231 (21%), Positives = 88/231 (38%), Gaps = 33/231 (14%) Query: 248 LNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKI 307 NAF NE + +++ E+ ++ C D +++ ++ Sbjct: 183 FNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTG---EITPDEA 239 Query: 308 INIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPY 367 +V L AG DT I ++ L P ++++ D + R+ + Sbjct: 240 PLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRS--DPTLARNA-----------F 286 Query: 368 MEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEF 427 EA E+ + F +TTR+ L G I +G V + N D + W +P + Sbjct: 287 EEAVRFESPVQTFF------RTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLY 340 Query: 428 LPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 I + S V FG G C+G+ +AR E + L+ L ++V Sbjct: 341 ----------DITRKTSGHVG-FGSGVHMCVGQLVARLEGEVMLSALARKV 380 >3P3Z-A nrPDB Length = 416 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 39/178 (21%), Positives = 71/178 (39%), Gaps = 28/178 (15%) Query: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSD 361 L D ++ +V + AG++T ++ ++ +P KI+E P L+ Sbjct: 238 LDDYELRTLVATVLVAGYETTNHQLALAMYDFAQHPDQWMKIKEN----------PELAP 287 Query: 362 RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLW 421 ++ + E R S +P T D + G IP G VF+ + D +++ Sbjct: 288 QA--------VEEVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVF 339 Query: 422 VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 + F D + + I FG G C+G +AR E+ +A L R++ Sbjct: 340 ADADRF--------DITVKR--EAPSIAFGGGPHFCLGTALARLELTEAVAALATRLD 387 >5GWE-A nrPDB Length = 405 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 54/228 (23%), Positives = 92/228 (40%), Gaps = 46/228 (20%) Query: 257 KFYSFMQKMVKEHYKTFEKGHIRD-ITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLF 315 +++ Q+MV + + H D +T L+ QE Q +++D +I +++ L Sbjct: 193 EYWQECQRMVADAH-----AHGGDNLTADLVRAQQEGQ-------EITDHEIASLLYSLL 240 Query: 316 GAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILET 375 AG +T TT IS L+ +P + I E P+L + A + E Sbjct: 241 FAGHETTTTLISNCFRVLLDHPEQWQAILE----------NPKL--------IPAAVDEV 282 Query: 376 FRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTP 435 R+S + +DT + G I +G V + N D+ + N EF Sbjct: 283 LRYSGSI-VGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEF-------- 333 Query: 436 DGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483 I + + + + FG G C+G +A+ L I L+ V VP Sbjct: 334 --DISRANAREHLSFGFGIHYCLGNMLAK----LQAKICLEEVTRLVP 375 >6A7I-A nrPDB Length = 411 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 49/208 (23%), Positives = 87/208 (41%), Gaps = 40/208 (19%) Query: 280 DITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRV 339 D+T +LI EN + L+DE+I+N + + AG +T + I + L +P Sbjct: 210 DLTSALIAAS------ENGD-HLTDEEIVNTLQLIIAAGHETTISLIVNVVEALQTHPEQ 262 Query: 340 QRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGF 399 ++K+ L+ IG + I ET R ++ + T D + Sbjct: 263 RKKV---LNGEIG---------------WDGVIEETLRWNTPTSHVLIRFATEDIEVGDK 304 Query: 400 YIPKGRCVFVNQWQINHDQKLW-VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCI 458 +PKG + ++ + D++ + EF R TP+ + I FG G C Sbjct: 305 ILPKGEGLIISFGALGRDEEQYGPTAGEFDATR--TPN---------RHIAFGHGPHVCP 353 Query: 459 GETIARWEVFLFLAILLQR---VEFSVP 483 G ++R E + L L +R ++ +VP Sbjct: 354 GAALSRLEAGIALPALYERFPELDLAVP 381 >5OFQ-A nrPDB Length = 409 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 56/236 (23%), Positives = 92/236 (38%), Gaps = 45/236 (19%) Query: 255 NEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLD--------ENANVQLSDEK 306 +E F MQK + F +G+ ++I + E Q KQ D E L++E+ Sbjct: 176 DEAFAKMMQK--RNEGVIFLQGYFKEI---IAERQQNKQEDLISLLLEAEIDGEHLTEEE 230 Query: 307 IINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLP 366 ++ + L AG +T T I+ + Y+ + VQ +++ ++ V P L Sbjct: 231 VLGFCILLLVAGNETTTNLITNGVRYMTEDVDVQNEVRRDISLV------PNL------- 277 Query: 367 YMEAFILETFRHSSFVPF-TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPS 425 + ET R+ + P I D L I +G+ V N D + P Sbjct: 278 -----VEETLRY--YPPIQAIGRIAAEDVELGECKIKRGQQVISWAASANRDSAKFEWPD 330 Query: 426 EFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFS 481 F+ R P + FG G C+G +AR E + LL++ FS Sbjct: 331 TFVVHRKTNPH-----------VSFGFGIHFCLGAPLARMEGKIAFTKLLEKGGFS 375 >6GK6-A nrPDB Length = 411 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 48/227 (21%), Positives = 90/227 (39%), Gaps = 35/227 (15%) Query: 255 NEKFYSFMQKMVKE---HYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIV 311 + +F Q +V+E +++ + D LI L E +LS ++ ++V Sbjct: 181 DREFVERAQPVVEEFAAYFRALADARRKAPRDDLISGLL---LAEEQEHKLSPAELSSMV 237 Query: 312 LDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAF 371 L AG +T I+ ++ L+ +P +R++ E+ ++G + Sbjct: 238 FLLLVAGHETTVHLIASGMLLLLSHPAERRRLDED-PGLVGSA----------------- 279 Query: 372 ILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPER 431 + E R + + D L G +P G V N D + + +P F R Sbjct: 280 VEEALRCEGPAELSTIRWSLEDIELFGARVPAGEGVAAGLLAANRDPQHFPDPDRFDIGR 339 Query: 432 FLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 +P+ + I FG G C+G +AR E + + LL+R+ Sbjct: 340 --SPN---------RHIGFGGGIHFCLGAMLARIEAAIAFSTLLRRL 375 >3ABA-A nrPDB Length = 403 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 41/183 (22%), Positives = 66/183 (36%), Gaps = 29/183 (15%) Query: 296 ENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSR 355 E+ + + D ++N L A DT I L+ +P Q + E +++G + Sbjct: 216 EDPDGVVDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDSPD-QLALLREDPSLVGNA- 273 Query: 356 RPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIN 415 + E R+ + F TRD L G I KG V + + Sbjct: 274 ----------------VEELLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAAD 317 Query: 416 HDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILL 475 D P F R P + FG G +CIG+ +AR E+ + L Sbjct: 318 FDPAFVEEPERFDITRRPAPH-----------LAFGFGAHQCIGQQLARIELQIVFETLF 366 Query: 476 QRV 478 +R+ Sbjct: 367 RRL 369 >1WIY-A nrPDB Length = 389 Score = 41.6 bits (96), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 47/194 (24%), Positives = 69/194 (35%), Gaps = 59/194 (30%) Query: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKI-----------QEELD- 348 L E+ ++ + L AG +TV +A++WS + L P Q+++ QE L Sbjct: 205 HLPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRVAESEEAALAAFQEALRL 264 Query: 349 -----TVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPK 403 + R RP L LP +L P+ T R Y P+ Sbjct: 265 YPPAWILTRRLERPLLLGEDRLPQGTTLVLS------------PYVTQR------LYFPE 306 Query: 404 GRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIA 463 G F PERFL G S + FG+G+R C+G A Sbjct: 307 GEA--------------------FQPERFLAERGTP----SGRYFPFGLGQRLCLGRDFA 342 Query: 464 RWEVFLFLAILLQR 477 E + L +R Sbjct: 343 LLEGPIVLRAFFRR 356 >5YHJ-A nrPDB Length = 413 Score = 41.6 bits (96), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 32/119 (26%), Positives = 44/119 (36%), Gaps = 27/119 (22%) Query: 371 FILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPE 430 F+ E R F P T D G+ P+G ++ + NHD +W P F P Sbjct: 275 FVQEVRRFYPFFPVAAARVKT-DFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPS 333 Query: 431 RF---------LTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 480 RF P G D + FG +C GE + +AIL Q +E Sbjct: 334 RFKDWKESPFNFIPQGGGD-------VDFG---HRCAGEHVT-------IAILAQVIEL 375 >3A1L-A nrPDB Length = 425 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 46/179 (25%), Positives = 69/179 (38%), Gaps = 38/179 (21%) Query: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSD 361 LS + I+ + L AG +T T ++ +++ L R R + +EL Sbjct: 239 LSVDGIVGTCVHLLTAGHETTTNFLAKAVLTL----RAHRDVLDEL-------------- 280 Query: 362 RSHLPYMEAFILETFRHSSFVPFTIPHSTTR----DTSLKGFYIPKGRCVFVNQWQINHD 417 R+ A + E R+ V + TR D L IP+G V N D Sbjct: 281 RTTPESTPAAVEELMRYDPPV-----QAVTRWAYEDIRLGDHDIPRGSRVVALLGSANRD 335 Query: 418 QKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ 476 P RF PD +E+ + FG+G C+G T+AR E + L LL Sbjct: 336 -----------PARFPDPDVLDVHRAAERQVGFGLGIHYCLGATLARAEAEIGLRALLD 383 >4XE3-A nrPDB Length = 407 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 61/294 (20%), Positives = 117/294 (39%), Gaps = 51/294 (17%) Query: 204 GRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRY------------LPNPSLNAF 251 RR + + SLV+ + ++V G+PAD + L +P + F Sbjct: 114 ARRVEEMRPRVRSLVD--SLLDDMVAHGSPADLVEFLAVPFPVAVICELLGVPLEDRDLF 171 Query: 252 KDLNEKFYSFMQ------KMVKEHYKTFEKGHIRDITDSLIEHCQEK-QLDENANVQLSD 304 + ++ S + + V++ + + G + D+ E L + + L+ Sbjct: 172 RTFSDAMLSSTRLTAAEIQRVQQDFMVYMDGLVAQRRDAPTEDLLGALALATDNDDHLTK 231 Query: 305 EKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSH 364 +I+N+ + L AG +T I+ +L++L++ +RK E L ++D + Sbjct: 232 GEIVNMGVSLLIAGHETSVNQIT-NLVHLLLT---ERKRYESL-----------VADPAL 276 Query: 365 LPYMEAFILETFRHSSFVPF-TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 423 +P A + E R++ V + T D L + G V+ N D++++ + Sbjct: 277 VP---AAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASANRDEEVFDH 333 Query: 424 PSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477 E R P I FG G CIG + R E+ L+ L++R Sbjct: 334 ADELDFHRERNPH-----------IAFGHGAHHCIGAQLGRLELQEALSALVRR 376 >5Z9I-A nrPDB Length = 398 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 30/178 (16%) Query: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360 +L+D +I NI L G T I+ +++ L D + R R + Sbjct: 221 KLNDSQISNIANRLLVNGHLTTAMLIANTMLCL--------------DAFSDQDARVR-A 265 Query: 361 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 420 DRS +P A + E+ R+ S + + +T + + G IPK + + V N D++ Sbjct: 266 DRSLVP---ALLEESMRYMSPI-CGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQ 321 Query: 421 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 + P F R +P+ + FG G C+G +AR E + ILL R+ Sbjct: 322 FEKPDVFDAGR--SPNAHLG---------FGRGIHFCLGRQLARMESKAAVEILLDRL 368 >2IJ7-A nrPDB Length = 396 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 45/208 (21%), Positives = 82/208 (39%), Gaps = 32/208 (15%) Query: 280 DITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRV 339 +IT L+ + D A +SDE I + FGAG + + ++ +L+ L+ P++ Sbjct: 197 NITTGLMGELSRLRKDP-AYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQL 255 Query: 340 QRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGF 399 + + E +P L + A + E R + +P T D + Sbjct: 256 RNLLHE----------KPEL--------IPAGVEELLRINLSFADGLPRLATADIQVGDV 297 Query: 400 YIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIG 459 + KG V V N D + + NP +D+ + FG G+ C G Sbjct: 298 LVRKGELVLVLLEGANFDPEHFPNPGSI----------ELDRPNPTSHLAFGRGQHFCPG 347 Query: 460 ETIARWEVFLFLAILLQR---VEFSVPL 484 + R + + LL++ V+ +VP+ Sbjct: 348 SALGRRHAQIGIEALLKKMPGVDLAVPI 375 >3A50-A nrPDB Length = 411 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 44/187 (23%), Positives = 76/187 (40%), Gaps = 30/187 (16%) Query: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360 +LS E+++ + + L AG +T I ++ L+ +P QRK+ E ++I + Sbjct: 220 RLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPD-QRKLLAEDPSLISSA------ 272 Query: 361 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 420 + E R S V T D + G IP G V + N D Sbjct: 273 -----------VEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRD--- 318 Query: 421 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILL-QRVE 479 ++++PE PD + + FG G C+G +AR E + + L R E Sbjct: 319 ----ADWMPE----PDRLDITRDASGGVFFGHGIHFCLGAQLARLEGRVAIGRLFADRPE 370 Query: 480 FSVPLGV 486 ++ +G+ Sbjct: 371 LALAVGL 377 >5FOI-A nrPDB Length = 408 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 37/178 (20%), Positives = 74/178 (41%), Gaps = 30/178 (16%) Query: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360 +++ ++++N + L AG +T ++ S++ L+ +P +++E+ P L Sbjct: 231 EITHQELVNNAVLLLAAGHETSANQVTLSVLTLLRHPETAAELREQ----------PEL- 279 Query: 361 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 420 M + E R+ S + + + T D L I G + + NHD Sbjct: 280 -------MPNAVDELLRYHS-IADGLRRAATADIVLGDHTIRAGDGLIILLSSANHDGNT 331 Query: 421 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 + + F R + + FG G +C+G+ +AR E+ + L L +RV Sbjct: 332 FGAEATFDIHRP-----------ARHHVAFGYGPHQCLGQNLARLEMEVTLGKLFRRV 378 >5IT1-A nrPDB Length = 399 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 39/182 (21%), Positives = 66/182 (36%), Gaps = 29/182 (15%) Query: 296 ENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSR 355 E+ + + D ++N L A DT I L+ P +Q++ ++IG + Sbjct: 216 EDPDGVIDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDRPDQLALLQKD-PSLIGNA- 273 Query: 356 RPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIN 415 + E R+ + F T+D + G I KG V + + Sbjct: 274 ----------------VEELLRYLTIGQFGAERVATQDGEIGGVRIAKGEQVVTHLLSAD 317 Query: 416 HDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILL 475 D +P F R P + FG G +CIG+ +AR E+ + L Sbjct: 318 FDPAFVEDPERFDITRRPAPH-----------LAFGFGAHQCIGQQLARIELQIVFGTLF 366 Query: 476 QR 477 +R Sbjct: 367 RR 368 >2QBO-A nrPDB Length = 421 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 61/266 (22%), Positives = 100/266 (37%), Gaps = 50/266 (18%) Query: 230 SGNPADFIPILRYL------PNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITD 283 +G P + IP L+YL P+ S+ F + E Y ++ ++++ + I + + Sbjct: 168 AGLPEEDIPHLKYLTDQMTRPDGSMT-FAEAKEALYDYLIPIIEQRRQKPGTDAISIVAN 226 Query: 284 SLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKI 343 + N SDE L L G DTV +S+S+ +L +P Sbjct: 227 GQV----------NGRPITSDEAKRMCGL-LLVVGLDTVVNFLSFSMEFLAKSP------ 269 Query: 344 QEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPK 403 E +I R R + A E R S V T D G + K Sbjct: 270 -EHRQELIERPER-----------IPAACEELLRRFSLV--ADGRILTSDYEFHGVQLKK 315 Query: 404 GRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIA 463 G + + Q D++ P D + KV FG G C+G+ +A Sbjct: 316 GDQILLPQMLSGLDERENACPMHV--------DFSRQKV---SHTTFGHGSHLCLGQHLA 364 Query: 464 RWEVFLFLAILLQRV-EFSVPLGVKV 488 R E+ + L L R+ +FS+ G ++ Sbjct: 365 RREIIVTLKEWLTRIPDFSIAPGAQI 390 >5NWS-A nrPDB Length = 435 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 46/196 (23%), Positives = 76/196 (38%), Gaps = 27/196 (13%) Query: 281 ITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQ 340 +TD L+ Q D+ +LSD + + ++L L AG +T I L+ +P Sbjct: 233 LTDDLLSELIRAQDDDGG--RLSDIETVTMILTLVLAGHETSAHLIGNGTAALLTHPGQW 290 Query: 341 RKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFY 400 ++++ P L R+ + E R V T D L G Sbjct: 291 ALLRKD----------PALLPRA--------VHELMRWCGSVHVARLRYATEDLELAGTP 332 Query: 401 IPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGE 460 + +G V + N D + + +P R + +E + FG G C+G Sbjct: 333 VARGDAVQLVLVSANFDPRHYSDPDRLDITRH-------QEGQAENHVGFGHGIHYCLGA 385 Query: 461 TIARWEVFLFLAILLQ 476 T+AR E + LA LL+ Sbjct: 386 TLARQEGEVALARLLE 401 >5L1U-A nrPDB Length = 401 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 50/227 (22%), Positives = 82/227 (36%), Gaps = 37/227 (16%) Query: 255 NEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDL 314 NE + Q++V + + + D L E EK + LSD I ++ + Sbjct: 179 NEHSANTFQQVVDYMLELVARKRVEPGDDILSELIAEK------DGALSDADIAHLGNAV 232 Query: 315 FGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILE 374 G++T I + L+ NP + ++ E+ P L+ P IL Sbjct: 233 LLFGYETTIVRIDLGTLLLLRNPVQRAQLAED----------PGLA-----PAAVEEILR 277 Query: 375 TFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 434 IP D ++ I G V + N+D + + Sbjct: 278 LGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAF------------- 324 Query: 435 PDGAI---DKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 PDG + +V + FG G R CIG T+AR E+ L +R+ Sbjct: 325 PDGGLFDLTRVRPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRL 371 >4YZR-A nrPDB Length = 405 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 52/239 (21%), Positives = 94/239 (39%), Gaps = 51/239 (21%) Query: 241 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDIT--DSLIEHCQEKQLDENA 298 R L N +L FKD ++ K++ H R I D LI +EN Sbjct: 183 RELTNQALREFKD-------YIAKLI----------HDRRIKPKDDLISKLV--HAEENG 223 Query: 299 NVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPR 358 + +LS++++ +++ L AG +T + + L+ + + K++++ + + Sbjct: 224 S-KLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIA------- 275 Query: 359 LSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQ 418 + E R++S V D + KG I +G +F+ N D Sbjct: 276 -----------TAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDP 324 Query: 419 KLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477 + NP R +P+ + I FG G C+G +AR E + LL+R Sbjct: 325 NFFENPEILNINR--SPN---------RHISFGFGIHFCLGAPLARLEGHIAFKALLKR 372 >2RFC-A nrPDB Length = 343 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 47/174 (27%), Positives = 69/174 (39%), Gaps = 36/174 (20%) Query: 304 DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 363 DEKI I+L + G G +T T I + + NP + +D L +RS Sbjct: 176 DEKIKYIMLLIIG-GNETTTNLIGNMIRVIDENPDI-------IDDA--------LKNRS 219 Query: 364 HLPYMEAFILETFRHSSFVPFTIPHS-TTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWV 422 F+ ET R+ S + F +PH D+ + I KG V V N D+ + Sbjct: 220 ------GFVEETLRYYSPIQF-LPHRFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFD 272 Query: 423 NPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ 476 P F R E + FG+G C+G +AR E + L +L Sbjct: 273 EPDLFKIGR------------REMHLAFGIGIHMCLGAPLARLEASIALNDILN 314 >6FSH-A nrPDB Length = 398 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 53/250 (21%), Positives = 96/250 (38%), Gaps = 49/250 (19%) Query: 254 LNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLD 313 L +KF ++ M+ K G I I + EH ++DE++ + + Sbjct: 186 LGDKFSRYLLAMIARERKDPGDGFIGSI---VAEHGD----------TITDEELRGVCVQ 232 Query: 314 LFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFIL 373 L AG D V+ I ++ L+ +P E++ + G + +DR+ + Sbjct: 233 LMLAGDDNVSGMIGLGVLALLRHP-------EQIAALRGDDQS---ADRA--------VD 274 Query: 374 ETFRHSSFVPFT-IPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERF 432 E R+ + VP+ P + D + I +G V + N D+ L + R Sbjct: 275 ELIRYLT-VPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTRT 333 Query: 433 LTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR---VEFSVPLGVKV- 488 P + FG G C+G + R ++ + L +R ++ + P + Sbjct: 334 PVPH-----------VAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQEIMF 382 Query: 489 -DMTPIYGLT 497 TP YGLT Sbjct: 383 RTSTPAYGLT 392 >5DE9-A nrPDB Length = 410 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 42/100 (42%), Gaps = 16/100 (16%) Query: 393 DTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGM 452 D +KG I G V+V+ N D +++ +P ER P + FG Sbjct: 300 DVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFERSPNPH-----------VSFGF 348 Query: 453 GKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTP 492 G C G +AR E L + +L RV G+K+ + P Sbjct: 349 GPHYCPGGMLARLESELLVDAVLDRVP-----GLKLAVAP 383 >4UBS-A nrPDB Length = 393 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 50/239 (20%), Positives = 89/239 (37%), Gaps = 43/239 (17%) Query: 241 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV 300 R L P + +D + ++ ++ K E G D L++ ++QL+ Sbjct: 167 RLLRGPGIAEVQDARAQLDDYLYALIDRKRK--EPG------DGLLDDLIQEQLNRGT-- 216 Query: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360 + +++++ L AG +T IS L+ +P +++ E P L Sbjct: 217 -VDRAELVSLATLLLIAGHETTANMISLGTFTLLRHPEQLAELRAE----------PGL- 264 Query: 361 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 420 M A + E R S + T D + G I V IN D Sbjct: 265 -------MPAAVEELLRFLSIADGLL-RVATEDIEVAGTTIRADEGVVFATSVINRDAAG 316 Query: 421 WVNPSEFLPERFLTPDGAIDKVLSEKV-IIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 + P A+D S + + FG G +C+G+ +AR E+ + L L +R+ Sbjct: 317 FAEPD------------ALDWHRSARHHVAFGFGIHQCLGQNLARAEMEIALGTLFERL 363 >1LG9-A nrPDB Length = 398 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 58/259 (22%), Positives = 96/259 (37%), Gaps = 67/259 (25%) Query: 254 LNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLD 313 L +KF ++ M+ K +G I + + ++A +DE++ + Sbjct: 186 LGDKFSRYLLAMIARERKEPGEGMIGAVV---------AEYGDDA----TDEELRGFCVQ 232 Query: 314 LFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFIL 373 + AG D ++ I ++ ++ +P E++D G + + + + Sbjct: 233 VMLAGDDNISGMIGLGVLAMLRHP-------EQIDAFRGDEQSAQRA-----------VD 274 Query: 374 ETFRHSSFVPFT-IPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERF 432 E R+ + VP++ P D +L G I KG V + N D L Sbjct: 275 ELIRYLT-VPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPAL------------ 321 Query: 433 LTPDGAIDKVLSEKV--IIFGMGKRKCIGETIAR----------WEVF--LFLAILLQRV 478 PD V E + + FG G C+G +AR W F L LA Q Sbjct: 322 -APDVDRLDVTREPIPHVAFGHGVHHCLGAALARLELRTVFTELWRRFPALRLADPAQDT 380 Query: 479 EFSVPLGVKVDMTPIYGLT 497 EF + TP YGLT Sbjct: 381 EFRL-------TTPAYGLT 392 >2UUQ-A nrPDB Length = 414 Score = 37.7 bits (86), Expect = 0.011, Method: Compositional matrix adjust. Identities = 45/174 (25%), Positives = 65/174 (37%), Gaps = 33/174 (18%) Query: 306 KIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHL 365 I+ + G DTVT + S+ P + R+ + RR L D + Sbjct: 239 SILAFTFTMVTGGNDTVTGMLGGSM------PLLHRRPDQ---------RRLLLDDPEGI 283 Query: 366 PYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPS 425 P + E R +S V + +TTRD ++ IP GR V + N D Sbjct: 284 PDA---VEELLRLTSPVQ-GLARTTTRDVTIGDTTIPAGRRVLLLYGSANRD-------- 331 Query: 426 EFLPERFLTPDGAIDKVLS--EKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477 ER PD A V ++ F G C+G AR + + L LL R Sbjct: 332 ----ERQYGPDAAELDVTRCPRNILTFSHGAHHCLGAAAARMQCRVALTELLAR 381 >3WVS-A nrPDB Length = 401 Score = 37.7 bits (86), Expect = 0.013, Method: Compositional matrix adjust. Identities = 60/281 (21%), Positives = 105/281 (37%), Gaps = 65/281 (23%) Query: 226 EVVGSGNPADFIPILRYLPNPSLN-------AFKDLNEKFYSFMQKMVKEHYKTFEKGHI 278 +++ G PAD + LP P+ F+D EKF + ++ E+G + Sbjct: 131 DMLAKGEPADLVADY-ALPIPTTVICELLGVPFED-REKFGRWTDAILSTSTLNPEEGRV 188 Query: 279 RDI-----------------TDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDT 321 + + D LI E + + +L+++++++ + L AG +T Sbjct: 189 KRMELVGYIGGIIAARRAQPADDLISGMIEAR---DVQDKLTEQELLDHCIGLLIAGHET 245 Query: 322 VTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSF 381 + I + L+ P+ +++ L D +P + + E FR F Sbjct: 246 TASQIPSFVYALLDQPQHWKRL---------------LDDPELIP---SAVEELFR---F 284 Query: 382 VPF----TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG 437 VP P D + G + G V V N D + +P E +R Sbjct: 285 VPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVALGAANRDGLRFEDPEEIKLDR------ 338 Query: 438 AIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 S I FG G C+G +AR E+ L LL+R+ Sbjct: 339 -----PSNHHIGFGHGIHHCLGAPLARLELQEALRALLERL 374 >2WIO-A nrPDB Length = 431 Score = 37.7 bits (86), Expect = 0.013, Method: Compositional matrix adjust. Identities = 51/200 (25%), Positives = 72/200 (36%), Gaps = 35/200 (17%) Query: 280 DITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRV 339 D D LI ++D A L DE+ N L AG T T + + L +P Sbjct: 227 DPGDDLISRLVLAEVDGRA---LDDEEAANFSTALLLAGHITTTVLLGNIVRTLDEHPAH 283 Query: 340 QRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGF 399 E D +P A + E R+ P + +TT+ T + G Sbjct: 284 WDAAAE---------------DPGRIP---AIVEEVLRYRPPFP-QMQRTTTKATEVAGV 324 Query: 400 YIPKGRCVFVNQWQI--NHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKC 457 IP V VN W + N D +P F P R K + FG G C Sbjct: 325 PIPAD--VMVNTWVLSANRDSDAHDDPDRFDPSR---------KSGGAAQLSFGHGVHFC 373 Query: 458 IGETIARWEVFLFLAILLQR 477 +G +AR E + L ++ R Sbjct: 374 LGAPLARLENRVALEEIIAR 393 >5L94-A nrPDB Length = 410 Score = 37.7 bits (86), Expect = 0.013, Method: Compositional matrix adjust. Identities = 65/280 (23%), Positives = 116/280 (41%), Gaps = 51/280 (18%) Query: 222 NNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDI 281 ++ +++ +G + L L + A +L FY +++ K G DI Sbjct: 162 KDWSDIIVAGPSNNERETLEKLQQEKMKANDELETYFYRIIEE------KRTRPGD--DI 213 Query: 282 TDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQR 341 L++ +E + QL+DE+I+ + L AG +T T IS + +Y +M + Sbjct: 214 ISVLLQAKEEGK-------QLTDEEIVGFSILLLIAGNETTTNLIS-NTIYCLMEDKAS- 264 Query: 342 KIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR-DTSLKGFY 400 R +R ++ LP + I E R+ S P H + D +L G Sbjct: 265 ---------FERLKR----EKELLP---SGIEEVLRYRS--PVQALHRIVKEDVTLAGKK 306 Query: 401 IPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGE 460 + G V + D + + +P F +R P+ + FG G C+G Sbjct: 307 LKAGEHVVPWMGSAHRDAEYFEDPEVFKIDR--KPNVHM---------AFGRGIHFCLGA 355 Query: 461 TIARWEVFLFLAILLQR---VEFSVPLGVK-VDMTPIYGL 496 +AR E + LA L+ R +++S +K ++ T +YGL Sbjct: 356 PLARIEAKIMLAELIDRYPQMDWSPSFELKPIESTFVYGL 395 >6HQG-A nrPDB Length = 425 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 44/173 (25%), Positives = 75/173 (43%), Gaps = 30/173 (17%) Query: 305 EKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSH 364 E + N++L + G G DT IS S++ L NP RK++E P L Sbjct: 251 EYLGNLILLIVG-GNDTTRNTISGSVLALHQNPDQDRKLREN----------PGL----- 294 Query: 365 LPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNP 424 + A + ET R + + + + RD L G I +G V + N D+++ P Sbjct: 295 ---IPAMVSETIRWQTPLAY-MRRRAKRDFELGGKTIREGDKVAMWYVSGNRDEEVIDRP 350 Query: 425 SEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477 +++ ER + + LS FG G +C+G +A ++ + +L R Sbjct: 351 NDYWIER-----PRVRQHLS-----FGFGVHRCVGNRLAELQLKIIWEEILAR 393 >2VZM-A nrPDB Length = 436 Score = 37.4 bits (85), Expect = 0.017, Method: Compositional matrix adjust. Identities = 55/253 (21%), Positives = 93/253 (36%), Gaps = 39/253 (15%) Query: 233 PADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFE-KGHIRDITDSLIEHCQE 291 P I L +P P AF+ + F F + E G++ + DS E Sbjct: 173 PITVISELLGVPEPDRAAFRVWTDAFV-FPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGE 231 Query: 292 KQL-------DENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQ 344 L DE+ + +L+ E+++ + L AG +T I+ + L+ +P Sbjct: 232 DLLSALVRTSDEDGS-RLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHP------- 283 Query: 345 EELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKG 404 ++L + R+ + ++ + E R+ V L G IP G Sbjct: 284 DQLAAL-----------RADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAG 332 Query: 405 RCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIAR 464 V V + + PERF P + + + FG G CIG +AR Sbjct: 333 DTVLVV-----------LADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLAR 381 Query: 465 WEVFLFLAILLQR 477 E + + LL+R Sbjct: 382 LEARIAVRALLER 394 >1Z8P-A nrPDB Length = 404 Score = 37.0 bits (84), Expect = 0.021, Method: Compositional matrix adjust. Identities = 54/211 (25%), Positives = 87/211 (41%), Gaps = 41/211 (19%) Query: 283 DSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRK 342 D L+ Q D++ +LS +++ +I L L AGF++ + I L+ +P Sbjct: 209 DDLLSALIRVQDDDDG--RLSADELTSIALVLLLAGFESSVSLIGIGTYLLLTHP----- 261 Query: 343 IQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR----DTSLKG 398 ++L V RR D S LP + E R+ P +TTR + + G Sbjct: 262 --DQLALV----RR----DPSALPNA---VEEILRY-----IAPPETTTRFAAEEVEIGG 303 Query: 399 FYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCI 458 IP+ V V N D K + +P F +T D + + FG G C+ Sbjct: 304 VAIPQYSTVLVANGAANRDPKQFPDPHRF----DVTRD-------TRGHLSFGQGIHFCM 352 Query: 459 GETIARWEVFLFLAILLQRVEFSVPLGVKVD 489 G +A+ E + L L R ++ LG+ D Sbjct: 353 GRPLAKLEGEVALRALFGRFP-ALSLGIDAD 382 >4YT3-A nrPDB Length = 410 Score = 37.0 bits (84), Expect = 0.022, Method: Compositional matrix adjust. Identities = 36/177 (20%), Positives = 73/177 (41%), Gaps = 30/177 (16%) Query: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPR-VQRKIQEELDTVIGRSRRPRLS 360 +D++++ + + GAG +T + ++ S L+ + + V +++ E LD V P+ Sbjct: 228 FTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDLV------PQ-- 279 Query: 361 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 420 +E F + + D L G + +G V V N D+++ Sbjct: 280 -----------AVEEMLRFRFNLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEM 328 Query: 421 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477 + +P I + ++K + FG G C+G +AR E + L L++ Sbjct: 329 FEDPFTL----------NIHRPNNKKHLTFGNGPHFCLGAPLARLEAKIALTAFLKK 375 >5LIV-A nrPDB Length = 450 Score = 37.0 bits (84), Expect = 0.023, Method: Compositional matrix adjust. Identities = 46/201 (22%), Positives = 79/201 (39%), Gaps = 36/201 (17%) Query: 279 RDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPR 338 RD +D+L+ E+ + + E IVL L G++T + ++ ++ L+ +P Sbjct: 244 RDTSDTLLGEILRTLKAEHMD---TIEASRQIVLSLILGGYETTSWLVANTIHALLAHPD 300 Query: 339 VQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVP--FTIPHSTTRDTSL 396 ++++ D S LP A I E R + P F + RD L Sbjct: 301 TLARVRQ---------------DPSLLP---AAIEEGMR---WCPSSFGVLRMVERDVRL 339 Query: 397 KGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRK 456 + G V + N+D+ + +P + ID+ +FG G Sbjct: 340 DDQALSAGTVVCLAGIAGNYDETAYPSPEVY----------DIDRKPLPAANVFGGGAHF 389 Query: 457 CIGETIARWEVFLFLAILLQR 477 C+G +AR E + L LL R Sbjct: 390 CVGAPLARMEARVGLQALLAR 410 >6F88-A nrPDB Length = 400 Score = 36.6 bits (83), Expect = 0.026, Method: Compositional matrix adjust. Identities = 46/201 (22%), Positives = 79/201 (39%), Gaps = 36/201 (17%) Query: 279 RDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPR 338 RD +D+L+ E+ + + E IVL L G++T + ++ ++ L+ +P Sbjct: 194 RDTSDTLLGEILRTLKAEHMD---TIEASRQIVLSLILGGYETTSWLVANTIHALLAHPD 250 Query: 339 VQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVP--FTIPHSTTRDTSL 396 ++++ D S LP A I E R + P F + RD L Sbjct: 251 TLARVRQ---------------DPSLLP---AAIEEGMR---WCPSNFGVLRMVERDVRL 289 Query: 397 KGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRK 456 + G V + N+D+ + +P + ID+ +FG G Sbjct: 290 DDQALSAGTVVCLAGIAGNYDETAYPSPEVY----------DIDRKPLPAANVFGGGAHF 339 Query: 457 CIGETIARWEVFLFLAILLQR 477 C+G +AR E + L LL R Sbjct: 340 CVGAPLARMEARVGLQALLAR 360 >3B98-A nrPDB Length = 475 Score = 36.6 bits (83), Expect = 0.027, Method: Compositional matrix adjust. Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 8/60 (13%) Query: 27 RASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVL 86 R + P + KG+ PW +GH L GK+ L+RM +++GD+ +R + VL Sbjct: 16 RRNEPPLDKGMI----PW----LGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVL 67 >4TX3-A nrPDB Length = 404 Score = 36.6 bits (83), Expect = 0.030, Method: Compositional matrix adjust. Identities = 56/261 (21%), Positives = 100/261 (38%), Gaps = 51/261 (19%) Query: 245 NPSLNAFK--DLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQL 302 + SL+A K E F ++ M+ K G I I + EH + Sbjct: 181 DASLSARKRAAAGEAFARYLVAMMARERKDPGDGFIGSI---VAEHGD----------TI 227 Query: 303 SDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDR 362 +DE++ + + L AG D V+ I ++ L+ +P E++ + G + +DR Sbjct: 228 TDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHP-------EQIAALRGDDQS---ADR 277 Query: 363 SHLPYMEAFILETFRHSSFVPFT-IPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLW 421 + + E R+ + VP+ P + D + I +G V + N D+ L Sbjct: 278 A--------VDELIRYLT-VPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALL 328 Query: 422 VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR---V 478 + R P + FG G C+G + R ++ + L +R + Sbjct: 329 PDADRLDVTRTPVPH-----------VAFGHGIHHCLGAALTRLQLRIAYTALWRRFPAL 377 Query: 479 EFSVPLGVKV--DMTPIYGLT 497 + + P + TP YGLT Sbjct: 378 QLADPAQEIMFRTSTPAYGLT 398 >6M7L-A nrPDB Length = 404 Score = 36.2 bits (82), Expect = 0.031, Method: Compositional matrix adjust. Identities = 37/183 (20%), Positives = 70/183 (38%), Gaps = 34/183 (18%) Query: 295 DENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRS 354 D A++ SDE++ + + + + + ++ + L+ +P ++E Sbjct: 224 DHGADI--SDEELAGLCAVVMNSSVEQTESCLAAGTLLLLEHPEQFALLRE--------- 272 Query: 355 RRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQI 414 RP L +++ + E R+ S P + T D + G I KG VF + Sbjct: 273 -RPELGEQA--------VEEIVRYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAA 323 Query: 415 NHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAIL 474 N +P+ DG + + FG G C+G +AR E+ + L Sbjct: 324 NR-----ADPAL---------DGFDITRKESRHVAFGHGIHHCLGAPLARMELRIAFTTL 369 Query: 475 LQR 477 + R Sbjct: 370 VSR 372 >5DQN-A nrPDB Length = 426 Score = 36.2 bits (82), Expect = 0.034, Method: Compositional matrix adjust. Identities = 55/242 (22%), Positives = 91/242 (37%), Gaps = 47/242 (19%) Query: 245 NPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSD 304 +P++++F+ S+ KM +E DI LIE + + +LSD Sbjct: 195 DPAMSSFE-----LISYAMKMAEERAVN----PTEDIVTKLIEADIDGE-------KLSD 238 Query: 305 EKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSH 364 ++ V+ L AG +T +I+ ++ NP Q EL + RP Sbjct: 239 DEFGFFVVMLAVAGNETTRNSITHGMIAFAQNPD-----QWEL----YKKERP------- 282 Query: 365 LPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNP 424 E E R ++ V + D L G I KG+ V ++ N D++++ +P Sbjct: 283 ----ETAADEIVRWATPVS-AFQRTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFEDP 337 Query: 425 SEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPL 484 F R P V G G CIG +AR + L + + P+ Sbjct: 338 HTFNILRSPNP----------HVGFGGTGAHYCIGANLARMTINLIFNAIADNMPDLKPI 387 Query: 485 GV 486 G Sbjct: 388 GA 389 >3RWL-A nrPDB Length = 426 Score = 36.2 bits (82), Expect = 0.035, Method: Compositional matrix adjust. Identities = 37/180 (20%), Positives = 72/180 (40%), Gaps = 29/180 (16%) Query: 298 ANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRP 357 A ++ E+ + VL L G DT +++ ++ L NP K+ Sbjct: 246 ATRNMTPEEYLGNVLLLIVGGNDTTRNSMTGGVLALHKNPDQFAKL-------------- 291 Query: 358 RLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHD 417 +++ +E + E R + + + + D+ L G I KG V + + N D Sbjct: 292 ----KANPALVETMVPEIIRWQTPLAH-MRRTAIADSELGGKTIRKGDKVVMWYYSGNRD 346 Query: 418 QKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477 ++ P EF+ ID+ + + FG G +C+G +A ++ + +L R Sbjct: 347 DEVIDRPEEFI----------IDRPRPRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTR 396 >1UED-A nrPDB Length = 406 Score = 36.2 bits (82), Expect = 0.036, Method: Compositional matrix adjust. Identities = 46/211 (21%), Positives = 73/211 (34%), Gaps = 43/211 (20%) Query: 295 DENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRS 354 D NV +DE++ + L G +TV I + ++ L+ NP + E + Sbjct: 225 DHGDNV--TDEELKGLCTALILGGVETVAGMIGFGVLALLDNPGQIELLFESPEKA---- 278 Query: 355 RRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQI 414 E + E R+ S V P +D + G I G V + Sbjct: 279 --------------ERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMA 324 Query: 415 NHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIAR---------- 464 N D+ L +P R D + FG G C+G +AR Sbjct: 325 NRDEALTPDPDVLDANRAAVSD-----------VGFGHGIHYCVGAALARSMLRMAYQTL 373 Query: 465 WEVF--LFLAILLQRVEFSVPLGVKVDMTPI 493 W F L LA+ ++ V++ D P+ Sbjct: 374 WRRFPGLRLAVPIEEVKYRSAFVDCPDQVPV 404 >6GII-A nrPDB Length = 479 Score = 36.2 bits (82), Expect = 0.037, Method: Compositional matrix adjust. Identities = 21/89 (23%), Positives = 41/89 (46%), Gaps = 10/89 (11%) Query: 390 TTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVII 449 TTR+ ++G +P G + + NHD + +P F I + + + + Sbjct: 362 TTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFF----------DIGRSNASEHLN 411 Query: 450 FGMGKRKCIGETIARWEVFLFLAILLQRV 478 FG G +C+G + R E+ + + L +R+ Sbjct: 412 FGYGAHQCLGRNLGRMEMQIMIEELSRRL 440 >2IAG-A nrPDB Length = 482 Score = 35.4 bits (80), Expect = 0.054, Method: Compositional matrix adjust. Identities = 46/231 (19%), Positives = 98/231 (42%), Gaps = 36/231 (15%) Query: 275 KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 334 + H +S + H +E + E + +VL L+ A + A W L++L+ Sbjct: 227 RAHRSKWLESYLLHLEEMGVSEEMQAR-------ALVLQLW-ATQGNMGPAAFWLLLFLL 278 Query: 335 MNPRVQRKIQEELDTVIGRSRRPRLSDRSHL--------PYMEAFILETFRHSS------ 380 NP ++ EL++++ ++ +P +S + L P +++ + E+ R ++ Sbjct: 279 KNPEALAAVRGELESILWQAEQP-VSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITR 337 Query: 381 --FVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGA 438 V +P + R+ +L+ R + D +++ +P F RFL PDG+ Sbjct: 338 EVVVDLAMPMADGREFNLRR----GDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGS 393 Query: 439 ID-------KVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSV 482 K L + +G G C+G + A + F+ ++L ++ + Sbjct: 394 EKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLEL 444 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 15/40 (37%), Positives = 24/40 (60%) Query: 47 PLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVL 86 P +G+ L GK+ L+RM +++GD+ I +G V VL Sbjct: 16 PWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVL 55 >6HQW-A nrPDB Length = 445 Score = 35.4 bits (80), Expect = 0.058, Method: Compositional matrix adjust. Identities = 21/89 (23%), Positives = 41/89 (46%), Gaps = 10/89 (11%) Query: 389 STTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVI 448 + T DT L G I G V + N D+ ++ NP + + +D+ + + + Sbjct: 336 TATADTELFGNQIKAGEKVILWYISANRDETVFENPDKLM----------VDRPNARRHL 385 Query: 449 IFGMGKRKCIGETIARWEVFLFLAILLQR 477 FG G +C+G +A ++ + L + +R Sbjct: 386 SFGHGIHRCVGARLAELQLRILLEEMHER 414 >3SN5-A nrPDB Length = 491 Score = 35.4 bits (80), Expect = 0.067, Method: Compositional matrix adjust. Identities = 39/182 (21%), Positives = 72/182 (39%), Gaps = 23/182 (12%) Query: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRP----------RLSDRSHLPYMEAFILE 374 A WSL ++ NP + EE+ + + + ++ + LP +++ I E Sbjct: 276 ATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKE 335 Query: 375 TFRHSSFVPFTIPHSTTRDTSLK----GFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPE 430 + R SS I + D +L + I K + + ++ D +++ +P F + Sbjct: 336 SLRLSS-ASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYD 393 Query: 431 RFLTPDGAIDKV-------LSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483 R+L +G L + FG G C G A E+ FL ++L E + Sbjct: 394 RYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELI 453 Query: 484 LG 485 G Sbjct: 454 EG 455 >5FYF-A nrPDB Length = 470 Score = 35.0 bits (79), Expect = 0.081, Method: Compositional matrix adjust. Identities = 22/88 (25%), Positives = 41/88 (46%), Gaps = 10/88 (11%) Query: 392 RDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFG 451 +D L G I KG V + N D++ + NP +F+ ID+ + + FG Sbjct: 363 QDVELGGQTIKKGDRVVMWYASGNRDERKFDNPDQFI----------IDRKDARNHMSFG 412 Query: 452 MGKRKCIGETIARWEVFLFLAILLQRVE 479 G +C+G +A ++ + +L+R + Sbjct: 413 YGVHRCMGNRLAELQLRILWEEILKRFD 440 >1F4U-A nrPDB Length = 368 Score = 35.0 bits (79), Expect = 0.083, Method: Compositional matrix adjust. Identities = 44/170 (25%), Positives = 69/170 (40%), Gaps = 32/170 (18%) Query: 298 ANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRP 357 N LSD + + ++ L AG +T T IS S++ QR +E L Sbjct: 190 VNSNLSDIEKLGYIILLLIAGNETTTNLISNSVIDFTRFNLWQRIREENL---------- 239 Query: 358 RLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHD 417 Y++A I E R+S V T+ + R L I +G V V N D Sbjct: 240 ---------YLKA-IEEALRYSPPVMRTVRKTKER-VKLGDQTIEEGEYVRVWIASANRD 288 Query: 418 QKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEV 467 ++++ + +F+P+R P + FG G C+G +AR E Sbjct: 289 EEVFHDGEKFIPDRNPNPH-----------LSFGSGIHLCLGAPLARLEA 327 >2WIY-A nrPDB Length = 394 Score = 34.7 bits (78), Expect = 0.097, Method: Compositional matrix adjust. Identities = 24/89 (26%), Positives = 37/89 (41%), Gaps = 9/89 (10%) Query: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIF 450 T D + G I G + N D +++ +P F R P A + + F Sbjct: 288 TEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTR---PPAA------SRNLSF 338 Query: 451 GMGKRKCIGETIARWEVFLFLAILLQRVE 479 G+G C G+ I+R E A+L +R E Sbjct: 339 GLGPHSCAGQIISRAEATTVFAVLAERYE 367 >5KYO-A nrPDB Length = 430 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 53/257 (20%), Positives = 98/257 (38%), Gaps = 50/257 (19%) Query: 233 PADFIPILRYL------PNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLI 286 P + +P L++L P+ S+ D+ ++F +++ +++ + + G D+ +I Sbjct: 192 PVEDLPKLKHLADQYTRPDGSI-PLDDVTKQFREYLRPVIE--ARRIKPGE--DMISRMI 246 Query: 287 EHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEE 346 E L+D + NI + + G DTV + ++ +L + ++R I + Sbjct: 247 N-------GEVGGRPLTDIEAENICIQVLVGGLDTVVNMLGFTFSHLAKDHALRRAIAAD 299 Query: 347 LDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRC 406 P L D + +LE FR V + RD +G + G Sbjct: 300 ----------PSLIDDA--------LLEFFRRFPVV--SSAREVLRDQEFEGVLLKAGDM 339 Query: 407 VFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWE 466 V + D +P EF R + + FG G C G +AR E Sbjct: 340 VMAPTVVVAMDDARNEDPLEFRLGR-----------KARQHSTFGKGSHTCPGAHLARME 388 Query: 467 VFLFLAILLQRV-EFSV 482 + + L R+ EF + Sbjct: 389 MKVVLREWFARIPEFRI 405 >5HIW-A nrPDB Length = 398 Score = 34.3 bits (77), Expect = 0.14, Method: Compositional matrix adjust. Identities = 20/86 (23%), Positives = 43/86 (50%), Gaps = 11/86 (12%) Query: 392 RDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFG 451 R+ ++ G + G ++++ ++D++++ P F R P G ++ FG Sbjct: 284 REATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDIHR--RPVGMLN---------FG 332 Query: 452 MGKRKCIGETIARWEVFLFLAILLQR 477 G C+G +AR E + +++LL+R Sbjct: 333 GGLHYCVGAPLARMEARVGVSLLLER 358 >1Q5D-A nrPDB Length = 419 Score = 33.9 bits (76), Expect = 0.18, Method: Compositional matrix adjust. Identities = 42/200 (21%), Positives = 77/200 (38%), Gaps = 34/200 (17%) Query: 296 ENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSR 355 E +LS ++++ +V + AG DT I+++++ L+ +P ++ E Sbjct: 233 EADGSRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAE--------- 283 Query: 356 RPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIN 415 P L M + E R + + +D G I KG VF+ Sbjct: 284 -PGL--------MRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIPSAL 334 Query: 416 HDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILL 475 D ++ P F R D S + +G G C G ++AR E + + + Sbjct: 335 RDGTVFSRPDVFDVRR--------DTSAS---LAYGRGPHVCPGVSLARLEAEIAVGTIF 383 Query: 476 QRVEFSVPLGVKVDMTPIYG 495 +R +K+ TP++G Sbjct: 384 RRFP-----EMKLKETPVFG 398 >4MM0-A nrPDB Length = 399 Score = 33.9 bits (76), Expect = 0.19, Method: Compositional matrix adjust. Identities = 37/177 (20%), Positives = 67/177 (37%), Gaps = 29/177 (16%) Query: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360 +L+D + ++ L L AG++ + + S++ L+ P D + R P L Sbjct: 220 ELTDHDVRSLSLILLLAGYEPASNQLGSSVLTLLRFP----------DRLAELRRDPGL- 268 Query: 361 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 420 + + + E R++ + T D ++ +IP V + N D Sbjct: 269 -------LPSAVEELMRYAPAGDGALFRVTLEDVTIGDTHIPANSAVLASTQAANWD--- 318 Query: 421 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477 P RF P G + G G C+G +AR E+ + + LL+R Sbjct: 319 --------PRRFDDPTGLRLDRPDNQHTALGHGIHFCLGAALARVELQVAIGALLRR 367 >5D3U-A nrPDB Length = 427 Score = 33.5 bits (75), Expect = 0.21, Method: Compositional matrix adjust. Identities = 27/138 (19%), Positives = 53/138 (38%), Gaps = 16/138 (11%) Query: 374 ETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFL 433 E R+++ FT +D + G I G+ + + N D ++ P++F Sbjct: 306 EVLRYNASNQFTW-RVAAKDVEMGGVRIEAGQTLALFLGSANRDANMFERPNDF------ 358 Query: 434 TPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPI 493 +D+ S + + FG G C+ + ++ F LL R G++ PI Sbjct: 359 ----DLDRPNSARHLSFGQGVHACLAAQLISLQLKWFYVALLNRFP-----GIRTAGEPI 409 Query: 494 YGLTMKHACCEHFQMQLR 511 + ++ + LR Sbjct: 410 WNENLEFRSLRSLPLSLR 427 >5XNT-A nrPDB Length = 411 Score = 33.5 bits (75), Expect = 0.24, Method: Compositional matrix adjust. Identities = 36/177 (20%), Positives = 74/177 (41%), Gaps = 30/177 (16%) Query: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPR-VQRKIQEELDTVIGRSRRPRLS 360 +D++++ + + GAG +T + ++ S L+ + + V +++ E LD V P+ Sbjct: 228 FTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDLV------PQA- 280 Query: 361 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 420 + E R+ F + + D L G + +G V V N D+++ Sbjct: 281 -----------VEEMLRYR-FNLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEM 328 Query: 421 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477 + + I + ++K + FG G C+G +AR E + L L++ Sbjct: 329 FEDAFTL----------NIHRPNNKKHLTFGNGPHFCLGAPLARLEAKIALTTFLKK 375 >2RCM-A nrPDB Length = 495 Score = 33.1 bits (74), Expect = 0.31, Method: Compositional matrix adjust. Identities = 27/116 (23%), Positives = 51/116 (43%), Gaps = 15/116 (12%) Query: 398 GFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFG------ 451 F + G ++ Q D K++ EF+PERF+ +G +K+L + G Sbjct: 380 AFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEEG--EKLLRHVLWSNGPETETP 437 Query: 452 -MGKRKCIGETIARWEVFLFLAILLQRVE-FSV-----PLGVKVDMTPIYGLTMKH 500 +G ++C G+ LF+ + +R + F + PLG V+ + + + H Sbjct: 438 TVGNKQCAGKDFVVLVARLFVIEIFRRYDSFDIEVGTSPLGSSVNFSSLRKASFHH 493 >6GMF-A nrPDB Length = 397 Score = 33.1 bits (74), Expect = 0.34, Method: Compositional matrix adjust. Identities = 40/178 (22%), Positives = 66/178 (37%), Gaps = 30/178 (16%) Query: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360 +L+ ++++ L AG +T T+ I +L+ L +P Q +L V Sbjct: 217 KLTAGEVLSFANTLLIAGNETTTSLIGNALVALTDHPEQLAAAQADLSLV---------- 266 Query: 361 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 420 A + E R+ S I T D + IP V N D+ Sbjct: 267 --------PAVVEEVLRYESPAQ-CIFRQTMTDVEIGDERIPARSVVLPLLASANRDESR 317 Query: 421 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 + +P F R ++ + FG+ CIG +AR E + L +LL R+ Sbjct: 318 FPDPDRFDIHRD-----------TKGHLAFGLDIHFCIGAPLARLEAKVMLEVLLARL 364 >1ODO-A nrPDB Length = 408 Score = 32.7 bits (73), Expect = 0.43, Method: Compositional matrix adjust. Identities = 42/184 (22%), Positives = 68/184 (36%), Gaps = 30/184 (16%) Query: 295 DENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRS 354 DE +LS E++ + +L + AG++T I ++ L+ P ++L V R Sbjct: 220 DEGDGDRLSPEELRDTLLLMISAGYETTVNVIDQAVHTLLTRP-------DQLALV--RK 270 Query: 355 RRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSL-KGFYIPKGRCVFVNQWQ 413 +D + ET RH V D +L G I +G + + Sbjct: 271 GEVTWAD---------VVEETLRHEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAA 321 Query: 414 INHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAI 473 N + F R + ++ + FG G C+G +AR EV L L Sbjct: 322 ANRHPDWHEDADTFDATRTV-----------KEHLAFGHGVHFCLGAPLARMEVTLALES 370 Query: 474 LLQR 477 L R Sbjct: 371 LFGR 374 >1UE8-A nrPDB Length = 367 Score = 32.3 bits (72), Expect = 0.45, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 41/98 (41%), Gaps = 12/98 (12%) Query: 374 ETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFL 433 E R S V TI T ++ I +G V V N D++++ +P F+P+R Sbjct: 246 EALRFSPPVMRTI-RVTKEKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSFIPDRTP 304 Query: 434 TPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFL 471 P + FG G C+G +AR E + L Sbjct: 305 NPH-----------LSFGSGIHLCLGAPLARLEARIAL 331 >2NZA-A nrPDB Length = 413 Score = 32.3 bits (72), Expect = 0.51, Method: Compositional matrix adjust. Identities = 21/86 (24%), Positives = 35/86 (40%), Gaps = 11/86 (12%) Query: 393 DTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGM 452 D + G I G V+V+ N D ++ +P +R P + +G Sbjct: 303 DVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDRDPNPH-----------LAYGN 351 Query: 453 GKRKCIGETIARWEVFLFLAILLQRV 478 G C G +AR + L + LL+R+ Sbjct: 352 GHHFCTGAVLARMQTELLVDTLLERL 377 >3BUJ-A nrPDB Length = 397 Score = 32.0 bits (71), Expect = 0.63, Method: Compositional matrix adjust. Identities = 42/175 (24%), Positives = 71/175 (40%), Gaps = 38/175 (21%) Query: 294 LDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGR 353 LD + +S +I++ V+ G +TV + + +++ L+ +P ++LD + Sbjct: 210 LDAHDRGLMSRNEIVSTVVTFIFTGHETVASQVGNAVLSLLAHP-------DQLDLL--- 259 Query: 354 SRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR----DTSLKGFYIPKGRCVFV 409 RRP L + + E R+ V S TR D L+G + + V V Sbjct: 260 RRRPDL--------LAQAVEECLRYDPSV-----QSNTRQLDVDVELRGRRLRRDDVVVV 306 Query: 410 NQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIAR 464 N D + + P +F ER P + FG G R C+G +AR Sbjct: 307 LAGAANRDPRRYDRPDDFDIERDPVPS-----------MSFGAGMRYCLGSYLAR 350 >4TRI-A nrPDB Length = 407 Score = 32.0 bits (71), Expect = 0.64, Method: Compositional matrix adjust. Identities = 27/107 (25%), Positives = 46/107 (42%), Gaps = 12/107 (11%) Query: 372 ILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPER 431 I E R +S V + + T DT G + G + + N D+ ++ +P F +R Sbjct: 270 IEEMLRWTSPVK-NMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDR 328 Query: 432 FLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 P+ + FG G C+G +AR E+ L +L+R+ Sbjct: 329 --NPNSHV---------AFGFGTHFCLGNQLARLELRLMTERVLRRL 364 >2XKR-A nrPDB Length = 398 Score = 31.6 bits (70), Expect = 0.79, Method: Compositional matrix adjust. Identities = 49/213 (23%), Positives = 85/213 (39%), Gaps = 37/213 (17%) Query: 270 YKTFEKGHIR----DITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTA 325 Y F + I D TD L+ ++D +LSD++++ L + G +T Sbjct: 182 YNDFTRATIAARRADPTDDLVSVLVSSEVD---GERLSDDELVMETLLILIGGDETTRHT 238 Query: 326 ISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFT 385 +S L+ N +++ D + R P L LP I E R ++ V Sbjct: 239 LSGGTEQLLRN-------RDQWDLL---QRDPSL-----LP---GAIEEMLRWTAPVK-N 279 Query: 386 IPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSE 445 + T DT G + G + + N D+ ++ P +F +R P+ + Sbjct: 280 MCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQR--NPNSHL------ 331 Query: 446 KVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 FG G C+G +AR E+ L +L+R+ Sbjct: 332 ---AFGFGTHFCLGNQLARLELSLMTERVLRRL 361 >3NV6-A nrPDB Length = 452 Score = 31.6 bits (70), Expect = 0.85, Method: Compositional matrix adjust. Identities = 20/46 (43%), Positives = 25/46 (54%), Gaps = 5/46 (10%) Query: 450 FGMGKRKCIGETIARWEVFLFLAILLQRV-EFSVPLGVKVDMTPIY 494 FG G +C G +AR EV + L L+R+ EFS G TPIY Sbjct: 392 FGGGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEG----ETPIY 433 >5OMS-A nrPDB Length = 409 Score = 31.6 bits (70), Expect = 0.91, Method: Compositional matrix adjust. Identities = 41/190 (21%), Positives = 68/190 (35%), Gaps = 29/190 (15%) Query: 275 KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 334 K IR + D LI+ E D I + + D G T + +Y+ Sbjct: 195 KAEIRAVVDPLIDKWIEHP---------DDSAISHWLHDGMPPG-QTRDREYIYPTIYVY 244 Query: 335 MNPRVQRKIQEELDTVIGRSRRPR-----LSDRSHLPYMEAFILETFRHSSFVPFTIPHS 389 + +Q T++G RP + D + +P I E R +S + Sbjct: 245 LLGAMQEPGHGMASTLVGLFSRPEQLEEVVDDPTLIPRA---IAEGLRWTSPIWSATARI 301 Query: 390 TTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVII 449 +T+ ++ G +P G V ++ NHD + PS++ R P + Sbjct: 302 STKPVTIAGVDLPAGTPVMLSYGSANHDTGKYEAPSQYDLHRPPLPH-----------LA 350 Query: 450 FGMGKRKCIG 459 FG G C G Sbjct: 351 FGAGNHACAG 360 >3DBM-A nrPDB Length = 473 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 36/148 (24%), Positives = 61/148 (41%), Gaps = 27/148 (18%) Query: 364 HLPYMEAFILETFRHSSFVP---------FTI-PHSTTRDTSLKGFYIPKGRCVFVNQWQ 413 +P ++ + E+ R VP FTI H T F + KG +F Q Sbjct: 326 QMPLTKSVVYESLRIEPPVPPQYGKAKSNFTIESHDAT-------FEVKKGEMLFGYQPF 378 Query: 414 INHDQKLWVNPSEFLPERFLTPDGAIDKVL----SEKVIIFGMGKRKCIGETIARWEVFL 469 D K++ P E++P+RF+ A+ K + + + ++C G+ L Sbjct: 379 ATKDPKVFDRPEEYVPDRFVGDGEALLKYVWWSNGPETESPTVENKQCAGKDFVVLITRL 438 Query: 470 FLAILLQRVE-FSV-----PLGVKVDMT 491 F+ L +R + F + PLG V +T Sbjct: 439 FVIELFRRYDSFEIELGESPLGAAVTLT 466 >5H1Z-A nrPDB Length = 407 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 18/89 (20%), Positives = 40/89 (44%), Gaps = 10/89 (11%) Query: 389 STTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVI 448 + T D+ L+G I G + + N D+ ++ N + +D+ + + + Sbjct: 298 TATVDSELEGQQIKAGDKLALWYISANRDESVFENADRII----------VDRPNARRHL 347 Query: 449 IFGMGKRKCIGETIARWEVFLFLAILLQR 477 FG G +C+G +A ++ + L + +R Sbjct: 348 AFGHGIHRCVGARLAELQIAVLLEEMAKR 376 >1NO7-A nrPDB Length = 604 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 12/34 (35%), Positives = 20/34 (58%), Gaps = 2/34 (5%) Query: 407 VFVNQW--QINHDQKLWVNPSEFLPERFLTPDGA 438 +F+N W ++ H + WV + PE+F+ PD A Sbjct: 54 LFLNAWGQRLAHGRVRWVAEGQMTPEQFMQPDNA 87 >3IVY-A nrPDB Length = 433 Score = 30.0 bits (66), Expect = 2.6, Method: Compositional matrix adjust. Identities = 52/221 (23%), Positives = 82/221 (37%), Gaps = 44/221 (19%) Query: 252 KDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIV 311 K + + + KM +E K + D ++ + +D +LSD++ V Sbjct: 214 KASSAELIGYAMKMAEEKAK--------NPADDIVTQLIQADID---GEKLSDDEFGFFV 262 Query: 312 LDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAF 371 + L AG +T +I+ +M +P Q EL + RP E Sbjct: 263 VMLAVAGNETTRNSITQGMMAFAEHPD-----QWELYKKV----RP-----------ETA 302 Query: 372 ILETFRHSSFVPFTIPHSTT-RDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPE 430 E R ++ P T T RD L G I KG+ V + N D++++ +P F Sbjct: 303 ADEIVRWAT--PVTAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNIL 360 Query: 431 RFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFL 471 R P V G G CIG +AR + L Sbjct: 361 RNPNP----------HVGFGGTGAHYCIGANLARMTINLIF 391 >5GRN-A nrPDB Length = 356 Score = 28.9 bits (63), Expect = 6.3, Method: Compositional matrix adjust. Identities = 19/81 (23%), Positives = 33/81 (40%), Gaps = 12/81 (14%) Query: 392 RDTSLKGFYIPKGR----CVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKV 447 RD + + + +G+ C F I HD S FLP +++ P+ D + + Sbjct: 200 RDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLS 259 Query: 448 IIFGMGKRKCIGETIARWEVF 468 ++ G I WE+F Sbjct: 260 DVWSYG--------ILLWEIF 272 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6DWN-A nrPDB 611 e-175 2HI4-A nrPDB 540 e-154 6B82-A nrPDB 463 e-131 5W0C-A nrPDB 450 e-127 2NNH-A nrPDB 449 e-126 4GQS-A nrPDB 442 e-124 1N6B-A nrPDB 436 e-122 4H1N-A nrPDB 428 e-120 3E6I-A nrPDB 419 e-117 2PG7-A nrPDB 416 e-116 5E0E-A nrPDB 411 e-115 5E58-A nrPDB 410 e-115 4R1Z-A nrPDB 408 e-114 5UYS-A nrPDB 404 e-113 3IBD-A nrPDB 401 e-112 4R20-A nrPDB 399 e-111 6IQ5-A nrPDB 399 e-111 3DL9-A nrPDB 374 e-104 3TBG-A nrPDB 367 e-102 3QZ1-A nrPDB 349 2e-96 5VBU-A nrPDB 344 7e-95 5YLW-A nrPDB 330 7e-91 6DA2-A nrPDB 308 3e-84 2WX2-A nrPDB 307 1e-83 3JUS-A nrPDB 304 4e-83 5VEU-A nrPDB 303 1e-82 3L4D-A nrPDB 301 6e-82 5FSA-A nrPDB 298 3e-81 4WMZ-A nrPDB 295 3e-80 6AYB-A nrPDB 294 5e-80 6CR2-A nrPDB 293 2e-79 5JLC-A nrPDB 288 3e-78 3K9V-A nrPDB 274 5e-74 2W0A-A nrPDB 274 6e-74 2X2N-A nrPDB 272 2e-73 6C94-A nrPDB 271 4e-73 2VE3-A nrPDB 269 2e-72 3EL3-A nrPDB 260 1e-69 3MDV-A nrPDB 220 1e-57 4KPA-A nrPDB 205 6e-53 3N9Z-A nrPDB 199 2e-51 3MZS-A nrPDB 191 4e-49 3EJB-B nrPDB 181 6e-46 3S79-A nrPDB 178 5e-45 2Z36-A nrPDB 176 1e-44 5OFQ-A nrPDB 174 5e-44 5Y1I-A nrPDB 174 9e-44 5VWS-A nrPDB 170 1e-42 2ZBZ-A nrPDB 170 1e-42 4JBT-A nrPDB 169 3e-42 4RM4-A nrPDB 168 6e-42 5LIE-A nrPDB 164 8e-41 4GGV-A nrPDB 164 1e-40 4ZGX-A nrPDB 163 1e-40 2Y5N-A nrPDB 163 2e-40 6M7X-A nrPDB 163 2e-40 3NC3-A nrPDB 163 2e-40 6A7J-A nrPDB 160 1e-39 5YSW-A nrPDB 160 1e-39 3ABB-A nrPDB 159 2e-39 5XW2-A nrPDB 158 6e-39 4OQR-A nrPDB 158 6e-39 4OQS-A nrPDB 158 6e-39 1EHE-A nrPDB 158 8e-39 4XE3-A nrPDB 157 1e-38 3ABA-A nrPDB 156 3e-38 2FR7-A nrPDB 155 4e-38 6B11-A nrPDB 155 5e-38 4Z5Q-A nrPDB 154 7e-38 5XJN-A nrPDB 154 1e-37 6GK6-A nrPDB 153 1e-37 5GWE-A nrPDB 153 1e-37 6A7I-A nrPDB 152 3e-37 4WPZ-A nrPDB 152 4e-37 5EX6-C nrPDB 151 5e-37 4DO1-A nrPDB 150 1e-36 6F0B-A nrPDB 150 1e-36 3P3Z-A nrPDB 148 6e-36 3TYW-A nrPDB 147 7e-36 1CPT-A nrPDB 146 3e-35 5Z9I-A nrPDB 145 5e-35 6FYJ-A nrPDB 144 1e-34 2ZQJ-A nrPDB 142 5e-34 3A1L-A nrPDB 140 1e-33 3MGX-A nrPDB 139 3e-33 5HDI-A nrPDB 138 5e-33 5M0P-A nrPDB 137 8e-33 3TKT-A nrPDB 136 2e-32 6G5O-A nrPDB 136 2e-32 2X9P-A nrPDB 131 5e-31 6DCD-A nrPDB 130 1e-30 3OFT-A nrPDB 128 7e-30 2IJ7-A nrPDB 124 9e-29 1WIY-A nrPDB 121 6e-28 3AWQ-A nrPDB 120 1e-27 5YHJ-A nrPDB 118 7e-27 6G71-A nrPDB 108 5e-24 Sequences not found previously or not previously below threshold: 5L94-A nrPDB 171 7e-43 4UBS-A nrPDB 166 3e-41 2VZM-A nrPDB 159 2e-39 5IT1-A nrPDB 158 6e-39 5CJE-A nrPDB 158 8e-39 3WVS-A nrPDB 154 6e-38 6GMF-A nrPDB 153 1e-37 4YZR-A nrPDB 153 2e-37 3A50-A nrPDB 153 2e-37 5FOI-A nrPDB 152 2e-37 3R9C-A nrPDB 150 1e-36 4Z5P-A nrPDB 149 2e-36 1Z8P-A nrPDB 149 2e-36 3SN5-A nrPDB 147 1e-35 1GWI-A nrPDB 144 1e-34 5NWS-A nrPDB 144 1e-34 5XNT-A nrPDB 144 1e-34 2WIO-A nrPDB 143 2e-34 6FSH-A nrPDB 142 5e-34 4YT3-A nrPDB 142 5e-34 1F4U-A nrPDB 141 1e-33 1LG9-A nrPDB 141 1e-33 4MM0-A nrPDB 140 1e-33 4TX3-A nrPDB 140 1e-33 1UED-A nrPDB 140 2e-33 1ODO-A nrPDB 139 2e-33 2RFC-A nrPDB 137 1e-32 5DQN-A nrPDB 137 1e-32 6HQG-A nrPDB 135 5e-32 4TRI-A nrPDB 132 4e-31 2WM5-A nrPDB 132 4e-31 6HQW-A nrPDB 132 4e-31 3RWL-A nrPDB 132 5e-31 6M7L-A nrPDB 130 2e-30 1Q5D-A nrPDB 129 2e-30 6CVC-A nrPDB 129 3e-30 1UE8-A nrPDB 129 4e-30 5FYF-A nrPDB 129 4e-30 3IVY-A nrPDB 126 2e-29 2XKR-A nrPDB 126 3e-29 6GII-A nrPDB 124 7e-29 5DE9-A nrPDB 124 1e-28 5LIV-A nrPDB 123 2e-28 6F88-A nrPDB 122 3e-28 5L1U-A nrPDB 121 9e-28 5H1Z-A nrPDB 118 5e-27 5HH3-A nrPDB 118 6e-27 3OO3-A nrPDB 116 2e-26 2WIY-A nrPDB 116 3e-26 3WEC-A nrPDB 115 4e-26 2UUQ-A nrPDB 114 9e-26 4PWV-A nrPDB 114 9e-26 6HQD-A nrPDB 111 7e-25 4FB2-A nrPDB 110 2e-24 6BLD-A nrPDB 107 1e-23 3B98-A nrPDB 106 2e-23 5HIW-A nrPDB 106 3e-23 2QBO-A nrPDB 105 4e-23 2NZA-A nrPDB 104 8e-23 2IAG-A nrPDB 104 8e-23 5EX8-A nrPDB 103 2e-22 3BUJ-A nrPDB 103 2e-22 5KYO-A nrPDB 102 4e-22 5D3U-A nrPDB 102 5e-22 5OMS-A nrPDB 97 2e-20 3NV6-A nrPDB 87 1e-17 4C9K-A nrPDB 84 2e-16 2RCM-A nrPDB 79 3e-15 3DBM-A nrPDB 76 3e-14 2YJN-B nrPDB 56 3e-08 3HGT-A nrPDB 32 0.68 5L9W-B nrPDB 31 1.3 4YXC-B nrPDB 31 1.3 4YXB-D nrPDB 31 1.4 5EY3-A nrPDB 31 1.7 4YYC-A nrPDB 31 1.9 5CQF-A nrPDB 30 2.3 2YMZ-A nrPDB 30 2.3 6IRV-A nrPDB 30 2.9 2NYG-A nrPDB 30 3.2 4DJD-D nrPDB 29 5.0 2BKC-A nrPDB 29 5.7 4J6E-A nrPDB 29 6.0 3RFT-A nrPDB 29 6.7 >6DWN-A nrPDB Length = 491 Score = 611 bits (1575), Expect = e-175, Method: Composition-based stats. Identities = 478/484 (98%), Positives = 480/484 (99%) Query: 29 SRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 88 ++ KGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG Sbjct: 2 AKKTSSKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 61 Query: 89 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 148 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA Sbjct: 62 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 121 Query: 149 SDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD 208 SDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD Sbjct: 122 SDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD 181 Query: 209 HNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKE 268 HNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKE Sbjct: 182 HNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKE 241 Query: 269 HYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISW 328 HYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISW Sbjct: 242 HYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISW 301 Query: 329 SLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPH 388 SLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPH Sbjct: 302 SLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPH 361 Query: 389 STTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVI 448 STTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVI Sbjct: 362 STTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVI 421 Query: 449 IFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQM 508 IFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQM Sbjct: 422 IFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQM 481 Query: 509 QLRS 512 QLRS Sbjct: 482 QLRS 485 >2HI4-A nrPDB Length = 495 Score = 540 bits (1392), Expect = e-154, Method: Composition-based stats. Identities = 354/486 (72%), Positives = 412/486 (84%), Gaps = 3/486 (0%) Query: 25 VIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVV 84 V++ RP+VPKGLK+PP PWGWPL+GH+LTLGKNPHLALSRMSQ+YGDVLQIRIGSTPV+ Sbjct: 3 VLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVL 62 Query: 85 VLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKS 144 VLS LDTIRQALVRQGDDFKGRPDLYT TLI++GQS++FS DSGPVWAARRRLAQN L + Sbjct: 63 VLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNT 122 Query: 145 FSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFG 204 FSIASDPASS+SCYLEEHVSKEA+ LIS LQELMAGPGHF+PY VVVSV NVI A+CFG Sbjct: 123 FSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFG 182 Query: 205 RRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQK 264 + + + E+LSLV + F E SGNP DF PILRYLPNP+L FK N++F F+QK Sbjct: 183 QHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQK 242 Query: 265 MVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTT 324 V+EHY+ F+K +RDIT +L +H K+ + + EKI+N+V D+FGAGFDTVTT Sbjct: 243 TVQEHYQDFDKNSVRDITGALFKHS--KKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTT 300 Query: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPF 384 AISWSLMYLV P +QRKIQ+ELDTVIGR RRPRLSDR LPY+EAFILETFRHSSF+PF Sbjct: 301 AISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPF 360 Query: 385 TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG-AIDKVL 443 TIPHSTTRDT+L GFYIPK CVFVNQWQ+NHD +LW +PSEF PERFLT DG AI+K L Sbjct: 361 TIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPL 420 Query: 444 SEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACC 503 SEK+++FGMGKR+CIGE +A+WE+FLFLAILLQ++EFSVP GVKVD+TPIYGLTMKHA C Sbjct: 421 SEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARC 480 Query: 504 EHFQMQ 509 EH Q + Sbjct: 481 EHVQAR 486 >6B82-A nrPDB Length = 509 Score = 463 bits (1191), Expect = e-131, Method: Composition-based stats. Identities = 155/486 (31%), Positives = 254/486 (52%), Gaps = 17/486 (3%) Query: 33 VPKGLKNPPGPWGWPLIGHMLTLGKN--PHLALSRMSQQYGDVLQIRIGSTPVVVLSGLD 90 VP G ++PP P+IG +++L + PH+ + ++YGD+ + +GS +++++ Sbjct: 18 VPAGNRSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHH 77 Query: 91 TIRQALVRQGDDFKGRPDLYTFTLIS-NGQSMSFSPDSGPVWAARRRLAQNGLKSFSIAS 149 ++ L+++G F GRP T L++ +G+ ++F+ D W R++ L F S Sbjct: 78 HAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFA-DYSSTWKFHRKMVHGALCMFGEGS 136 Query: 150 DPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDH 209 +E+ + +EA + L E P + +VTNV+CA+CF Y Sbjct: 137 VS-------IEKIICREASSMCEVLTESQNSAVDLGP--ELTRAVTNVVCALCFNSSYKR 187 Query: 210 NHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEH 269 E S++ + + V + D P L+ PN L + +QK +EH Sbjct: 188 GDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLRILRQCISIRDKLLQKKYEEH 247 Query: 270 YKTFEKGHIRDITDSLIEH--CQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAIS 327 T+ RD+ D+L+ E +V L+++ ++ V ++FGAG +T TT + Sbjct: 248 KVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTTLK 307 Query: 328 WSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIP 387 WS+ YLV NP+VQRKIQEELD+ IG+ R P+LSDR +LPY+EA I E R P IP Sbjct: 308 WSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIP 367 Query: 388 HSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKV 447 H +D+S+ + + KG V +N W ++HD+K W NP F P RFL +G S Sbjct: 368 HVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSY 427 Query: 448 IIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKV-DMTPIYGLTMKHACCEHF 506 + FG G R C+GE +A+ E+FLFLA +LQR +P G + D+ +G+ ++ + Sbjct: 428 LPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKKFK-V 486 Query: 507 QMQLRS 512 ++R+ Sbjct: 487 VAKVRA 492 >5W0C-A nrPDB Length = 477 Score = 450 bits (1157), Expect = e-127, Method: Composition-based stats. Identities = 146/470 (31%), Positives = 250/470 (53%), Gaps = 21/470 (4%) Query: 29 SRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLS 87 ++ K PPGP P+IG++L +G K+ +L+ +S+ YG V + G P+VVL Sbjct: 2 AKKTSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH 61 Query: 88 GLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSI 147 G + +++AL+ G++F GR + G + FS +G W RR + L++F + Sbjct: 62 GYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFS--NGKKWKEIRRFSLMTLRNFGM 119 Query: 148 ASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRY 207 +E+ V +EA L+ L++ A P +P + + NVIC+I F +R+ Sbjct: 120 GKRS-------IEDRVQEEARCLVEELRKTKASPC--DPTFILGCAPCNVICSIIFHKRF 170 Query: 208 DHNHQELLSLVNLNNNFGEVVGSGNP---ADFIPILRYLPNPSLNAFKDLNEKFYSFMQK 264 D+ Q+ L+L+ N +++ S +F PI+ Y P K++ S++ + Sbjct: 171 DYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNV-AFMKSYILE 229 Query: 265 MVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTT 324 VKEH ++ + + +D D + ++++ N + + E + N +DLFGAG +T +T Sbjct: 230 KVKEHQESMDMNNPQDFIDCFLMKMEKEK--HNQPSEFTIESLENTAVDLFGAGTETTST 287 Query: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPF 384 + ++L+ L+ +P V K+QEE++ VIGR+R P + DRSH+PY +A + E R+ +P Sbjct: 288 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPT 347 Query: 385 TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLS 444 ++PH+ T D + + IPKG + ++ + HD K + NP F P FL G K S Sbjct: 348 SLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKK--S 405 Query: 445 EKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTPI 493 + + F GKR C+GE +A E+FLFL +LQ + K +D TP+ Sbjct: 406 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPV 455 >2NNH-A nrPDB Length = 476 Score = 449 bits (1155), Expect = e-126, Method: Composition-based stats. Identities = 148/492 (30%), Positives = 245/492 (49%), Gaps = 32/492 (6%) Query: 29 SRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLS 87 ++ KG K PPGP P+IG+ML + K+ + + S+ YG V + G P+VV Sbjct: 2 AKKTSSKG-KLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFH 60 Query: 88 GLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSI 147 G + +++AL+ G++F GR + I+ G + S +G W RR + L++F + Sbjct: 61 GYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISS--NGKRWKEIRRFSLTTLRNFGM 118 Query: 148 ASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRY 207 +E+ V +EA L+ L++ A P +P + + NVIC++ F +R+ Sbjct: 119 GKRS-------IEDRVQEEAHCLVEELRKTKASPC--DPTFILGCAPCNVICSVVFQKRF 169 Query: 208 DHNHQELLSLVNLNNNFGEVVGSGNP---ADFIPILRYLPNPSLNAFKDLNEKFYSFMQK 264 D+ Q L+L+ N ++ S +F ++ P K++ S++++ Sbjct: 170 DYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNV-ALTRSYIRE 228 Query: 265 MVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTT 324 VKEH + + + RD D + ++++ +N + + E ++ V DLF AG +T +T Sbjct: 229 KVKEHQASLDVNNPRDFIDCFLIKMEQEK--DNQKSEFNIENLVGTVADLFVAGTETTST 286 Query: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPF 384 + + L+ L+ +P V K+QEE+D VIGR R P + DRSH+PY +A + E R+S VP Sbjct: 287 TLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPT 346 Query: 385 TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLS 444 +PH+ T DT + + IPKG + + HD K + NP+ F P FL +G K S Sbjct: 347 GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKK--S 404 Query: 445 EKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-----------VDMTPI 493 + + F GKR C GE +AR E+FLFL +LQ +K V + P Sbjct: 405 DYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPS 464 Query: 494 YGLTMKHACCEH 505 Y + H Sbjct: 465 YQICFIPVHHHH 476 >4GQS-A nrPDB Length = 477 Score = 442 bits (1136), Expect = e-124, Method: Composition-based stats. Identities = 142/470 (30%), Positives = 242/470 (51%), Gaps = 21/470 (4%) Query: 29 SRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLS 87 ++ K PPGP P+IG++L + K+ +L+ +S+ YG V + G +VVL Sbjct: 2 AKKTSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLH 61 Query: 88 GLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSI 147 G + +++AL+ G++F GR + G + FS +G W RR + L++F + Sbjct: 62 GYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFS--NGKRWKEIRRFSLMTLRNFGM 119 Query: 148 ASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRY 207 +E+ V +EA L+ L++ A P +P + + NVIC+I F +R+ Sbjct: 120 GKRS-------IEDRVQEEARCLVEELRKTKASPC--DPTFILGCAPCNVICSIIFQKRF 170 Query: 208 DHNHQELLSLVNLNNNFGEVVGSGNP---ADFIPILRYLPNPSLNAFKDLNEKFYSFMQK 264 D+ Q+ L+L+ N +V + +F I+ Y P K+L S + + Sbjct: 171 DYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNL-AFMESDILE 229 Query: 265 MVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTT 324 VKEH ++ + + RD D + ++++ +N + + E ++ DL GAG +T +T Sbjct: 230 KVKEHQESMDINNPRDFIDCFLIKMEKEK--QNQQSEFTIENLVITAADLLGAGTETTST 287 Query: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPF 384 + ++L+ L+ +P V K+QEE++ V+GR+R P + DR H+PY +A + E R+ +P Sbjct: 288 TLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 347 Query: 385 TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLS 444 ++PH+ T D + + IPKG + + + HD K + NP F P FL G K S Sbjct: 348 SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK--S 405 Query: 445 EKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTPI 493 + F GKR C+GE +AR E+FLFL +LQ + K +D TP+ Sbjct: 406 NYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPV 455 >1N6B-A nrPDB Length = 473 Score = 436 bits (1121), Expect = e-122, Method: Composition-based stats. Identities = 151/492 (30%), Positives = 252/492 (51%), Gaps = 35/492 (7%) Query: 29 SRPQVPKGLKNPPGPWGWPLIGHMLTL-GKNPHLALSRMSQQYGDVLQIRIGSTPVVVLS 87 ++ KG K PPGP +P+IG++L + K+ +L++ S+ YG V + +G P VVL Sbjct: 2 AKKTSSKG-KLPPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLH 60 Query: 88 GLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSI 147 G + +++ALV G++F GR + +S G ++FS + W RR + L++F + Sbjct: 61 GYEAVKEALVDLGEEFAGRGSVPILEKVSKGLGIAFS--NAKTWKEMRRFSLMTLRNFGM 118 Query: 148 ASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRY 207 +E+ + +EA L+ L++ A P +P + + NVIC++ F R+ Sbjct: 119 GKRS-------IEDRIQEEARCLVEELRKTNASPC--DPTFILGCAPCNVICSVIFHNRF 169 Query: 208 DHNHQELLSLVNLNNNFGEVVGSGNP---ADFIPILRYLPNPSLNAFKDLNEKFYSFMQK 264 D+ +E L L+ + E++G+ +F +L Y P K+ + +F+ + Sbjct: 170 DYKDEEFLKLMESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNAD-YIKNFIME 228 Query: 265 MVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTT 324 VKEH K + + RD D + +++ N++ + E ++ V DLFGAG +T +T Sbjct: 229 KVKEHQKLLDVNNPRDFIDCFLIKMEQE-----NNLEFTLESLVIAVSDLFGAGTETTST 283 Query: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPF 384 + +SL+ L+ +P V ++QEE++ VIGR R P + DRS +PY +A I E R +P Sbjct: 284 TLRYSLLLLLKHPEVAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPT 343 Query: 385 TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLS 444 +PH+ TRD + ++IPKG + + + HD+K + NP F P FL G K S Sbjct: 344 NLPHAVTRDVRFRNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKK--S 401 Query: 445 EKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-----------VDMTPI 493 + + F GKR C+GE +AR E+FLFL +LQ + + K V + P Sbjct: 402 DYFMPFSAGKRMCVGEGLARMELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPS 461 Query: 494 YGLTMKHACCEH 505 Y L H Sbjct: 462 YQLCFIPIHHHH 473 >4H1N-A nrPDB Length = 479 Score = 428 bits (1101), Expect = e-120, Method: Composition-based stats. Identities = 145/469 (30%), Positives = 244/469 (52%), Gaps = 22/469 (4%) Query: 29 SRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHL-ALSRMSQQYGDVLQIRIGSTPVVVLS 87 ++ KG K PPGP P++G++L + + L + R+ ++YGDV + +GS PVVVL Sbjct: 2 AKKTSSKG-KLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLC 60 Query: 88 GLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSI 147 G D IR+ALV Q + F GR + I G + F+ +G W A RR + ++ F + Sbjct: 61 GTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFA--NGERWRALRRFSLATMRDFGM 118 Query: 148 ASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRY 207 +EE + +EA L+ L++ + +N+IC+I FG+R+ Sbjct: 119 GKRS-------VEERIQEEARCLVEELRKSKG--ALLDNTLLFHSITSNIICSIVFGKRF 169 Query: 208 DHNHQELLSLVNLNNNFGEVVGSGNPADF---IPILRYLPNPSLNAFKDLNEKFYSFMQK 264 D+ L L++L ++ S + F L+Y P +++L E +F+ + Sbjct: 170 DYKDPVFLRLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQE-INTFIGQ 228 Query: 265 MVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTT 324 V++H T + + RD D + ++ + D + + + +I VL LF AG +T +T Sbjct: 229 SVEKHRATLDPSNPRDFIDVYLLRMEKDKSDPS--SEFHHQNLILTVLSLFAAGTETTST 286 Query: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPF 384 + + + ++ P V ++Q+E++ VIG R P L DR+ +PY +A I E R +PF Sbjct: 287 TLRYGFLLMLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPF 346 Query: 385 TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLS 444 +PH+ T+DT +G+ IPK VF HD + + P+ F P FL +GA+ + + Sbjct: 347 GVPHTVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKR--N 404 Query: 445 EKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTP 492 E + F +GKR C+GE IAR E+FLF +LQ + P+ + +D+TP Sbjct: 405 EGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTP 453 >3E6I-A nrPDB Length = 476 Score = 419 bits (1076), Expect = e-117, Method: Composition-based stats. Identities = 145/471 (30%), Positives = 246/471 (52%), Gaps = 23/471 (4%) Query: 29 SRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLS 87 ++ KG K PPGP+ P+IG++ L KN + +R++Q++G V + +GS +VV+ Sbjct: 2 AKKTSSKG-KLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 60 Query: 88 GLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSI 147 G +++AL+ D+F GR DL F + + F ++GP W RR + L+++ + Sbjct: 61 GYKAVKEALLDYKDEFSGRGDLPAFHA-HRDRGIIF--NNGPTWKDIRRFSLTTLRNYGM 117 Query: 148 ASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRY 207 E + +EA L+ L++ P F+P + + NVI I F + + Sbjct: 118 GKQGN-------ESRIQREAHFLLEALRKTQGQP--FDPTFLIGCAPCNVIADILFRKHF 168 Query: 208 DHNHQELLSLVNLNNNFGEVVGSGNP---ADFIPILRYLPNPSLNAFKDLNEKFYSFMQK 264 D+N ++ L L+ L N ++ + +F L YLP K++ + ++ + Sbjct: 169 DYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNV-AEVKEYVSE 227 Query: 265 MVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTT 324 VKEH+++ + RD+TD L+ ++++ +A + + I V DLF AG +T +T Sbjct: 228 RVKEHHQSLDPNCPRDLTDCLLVEMEKEK--HSAERLYTMDGITVTVADLFFAGTETTST 285 Query: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPF 384 + + L+ L+ P ++ K+ EE+D VIG SR P + DR +PYM+A + E R + VP Sbjct: 286 TLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 345 Query: 385 TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLS 444 +PH TRDT +G+ IPKG V + +D + + +P +F PE FL +G S Sbjct: 346 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFK--YS 403 Query: 445 EKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTPIY 494 + F GKR C GE +AR E+FL L +LQ + K +D++PI+ Sbjct: 404 DYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIH 454 >2PG7-A nrPDB Length = 476 Score = 416 bits (1068), Expect = e-116, Method: Composition-based stats. Identities = 148/471 (31%), Positives = 245/471 (52%), Gaps = 22/471 (4%) Query: 29 SRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLS 87 ++ KG K PPGP P IG+ L L + + +L ++S++YG V I +G VVVL Sbjct: 2 AKKTSSKG-KLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLC 60 Query: 88 GLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSI 147 G D +R+ALV Q ++F GR + TF + G + FS +G RR + L+ F + Sbjct: 61 GHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFS--NGERAKQLRRFSIATLRDFGV 118 Query: 148 ASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRY 207 +EE + +EA LI L+ G + +P ++ +V+NVI +I FG R+ Sbjct: 119 GKRG-------IEERIQEEAGFLIDALRGT--GGANIDPTFFLSRTVSNVISSIVFGDRF 169 Query: 208 DHNHQELLSLVNLNNNFGEVVGSGNPA---DFIPILRYLPNPSLNAFKDLNEKFYSFMQK 264 D+ +E LSL+ + + + F ++++LP P AF L + F+ K Sbjct: 170 DYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAF-QLLQGLEDFIAK 228 Query: 265 MVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTT 324 V+ + +T + RD DS + QE+ ++N N + + ++ L LF G +TV+T Sbjct: 229 KVEHNQRTLDPNSPRDFIDSFLIRMQEE--EKNPNTEFYLKNLVMTTLQLFVGGTETVST 286 Query: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPF 384 + + + L+ +P V+ K+ EE+D VIG++R+P+ DR+ +PYMEA I E R +P Sbjct: 287 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPM 346 Query: 385 TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLS 444 ++ +DT + F++PKG V+ + D + NP +F P+ FL G K S Sbjct: 347 SLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKK--S 404 Query: 445 EKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTPIY 494 + + F +GKR C GE +AR E+FLF ++Q K +D++P + Sbjct: 405 DAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKH 455 >5E0E-A nrPDB Length = 463 Score = 411 bits (1055), Expect = e-115, Method: Composition-based stats. Identities = 137/447 (30%), Positives = 228/447 (51%), Gaps = 21/447 (4%) Query: 51 HMLTLGKNPHL-ALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDL 109 ++L + + L + R+ ++YGDV + +G PVV+L G + IR+ALV Q + F GR + Sbjct: 14 NLLQMDRGGFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 73 Query: 110 YTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEV 169 I G + F+ +G W A RR + ++ F + +EE + +EA Sbjct: 74 AVVEPIFRGYGVVFA--NGERWKALRRFSLVTMRDFGMGKRS-------VEERIQEEARC 124 Query: 170 LISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVG 229 L+ ++ P +P N+IC+I FG R+D+ + L L+ L ++ Sbjct: 125 LVEEFRKSQGAP--LDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLIS 182 Query: 230 SGNPADF---IPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLI 286 S + F L+Y P ++L E ++ + V++H T + H RD D+ + Sbjct: 183 SFSSQVFELFSGFLKYFPGTHRQISRNLQEIL-DYIGQSVEKHRATLDPSHPRDFIDTYL 241 Query: 287 EHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEE 346 ++++ N + + + ++ VL LF AG +T +T + + + ++ P V K+Q+E Sbjct: 242 LRMEKEK--SNQHTEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKE 299 Query: 347 LDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRC 406 +D VIG R P L DR+ +PY EA I E R S +P +PH T+DT +G+ +PK Sbjct: 300 IDQVIGSHRLPTLEDRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTE 359 Query: 407 VFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWE 466 V+ HD + + P F P+ FL +GA+ K SE + F +GKR C+GE IAR E Sbjct: 360 VYPILSSALHDPQYFEQPDTFNPDHFLDANGALKK--SEAFMPFSIGKRICLGEGIARNE 417 Query: 467 VFLFLAILLQRVEFSVPLGVK-VDMTP 492 +FLF +LQ S P+ K +D++P Sbjct: 418 LFLFFTTILQNFSLSSPVAPKDIDLSP 444 >5E58-A nrPDB Length = 493 Score = 410 bits (1053), Expect = e-115, Method: Composition-based stats. Identities = 134/447 (29%), Positives = 227/447 (50%), Gaps = 21/447 (4%) Query: 51 HMLTLGKNPHL-ALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDL 109 ++L + + L + R+ ++YGDV + +G PVV+L G + IR+ALV Q + F GR + Sbjct: 42 NLLQMDRGGFLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 101 Query: 110 YTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEV 169 + M FS +G W RR + ++ F + +E+ + +EA+ Sbjct: 102 AVIKPVIGDYGMIFS--NGERWKVLRRFSLATMRDFGMGKRS-------VEDRIQEEAQC 152 Query: 170 LISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVG 229 L+ LQ+ P +P N+IC+I FG RYD+ ++ L L++L ++ Sbjct: 153 LVEELQKSQGAP--LDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMS 210 Query: 230 SGNPADF---IPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLI 286 S + F ++Y P ++L E ++ + V++H T + + RD D+ + Sbjct: 211 SFSSQVFELFSGFMKYFPGAHRQITRNLQEIL-DYVGQSVEKHRATLDPSNPRDFIDTYL 269 Query: 287 EHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEE 346 ++++ N + + + ++ VL LF AG +T +T + + + ++ P V K+Q+E Sbjct: 270 LRMEKEK--SNQHTEFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKE 327 Query: 347 LDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRC 406 +D VIG R P L DR+ +PY +A I E R S P PH T+DT +G+ +PK Sbjct: 328 IDQVIGSHRLPTLEDRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTE 387 Query: 407 VFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWE 466 V+ HD + + P F P+ FL +GA+ K SE + F +GKR C+GE IAR E Sbjct: 388 VYPILSSALHDPQYFEQPGTFNPDHFLDANGALKK--SEAFMPFSIGKRICLGEGIARNE 445 Query: 467 VFLFLAILLQRVEFSVPLGVK-VDMTP 492 +FLF +LQ S + K +D++P Sbjct: 446 LFLFFTTILQNFSVSSSVAPKDIDLSP 472 >4R1Z-A nrPDB Length = 439 Score = 408 bits (1048), Expect = e-114, Method: Composition-based stats. Identities = 142/439 (32%), Positives = 227/439 (51%), Gaps = 15/439 (3%) Query: 78 IGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLIS-NGQSMSFSPDSGPVWAARRR 136 +GS +++++ ++ L+++G F GRP T L++ +G+ ++F+ D W R+ Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFA-DYSSTWKFHRK 59 Query: 137 LAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTN 196 + L F S +E+ + +EA + L E P + +VTN Sbjct: 60 MVHGALCMFGEGSVS-------IEKIICREASSMCEVLTESQNSAVDLGP--ELTRAVTN 110 Query: 197 VICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNE 256 V+CA+CF Y E S++ + + V + D P L+ PN L + Sbjct: 111 VVCALCFNSSYKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLTILRQCIS 170 Query: 257 KFYSFMQKMVKEHYKTFEKGHIRDITDSLIEH--CQEKQLDENANVQLSDEKIINIVLDL 314 +QK +EH T+ RD+ D+L+ E +V L+++ ++ V D+ Sbjct: 171 IRDKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDI 230 Query: 315 FGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILE 374 FGAG +T TT + WS+ YLV NP+VQRKIQEELD+ IG+ R P+LSDR +LPY+EA I E Sbjct: 231 FGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIRE 290 Query: 375 TFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 434 R P IPH +D+S+ + + KG V +N W ++HD+K W NP F P RFL Sbjct: 291 VLRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLN 350 Query: 435 PDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKV-DMTPI 493 +G S + FG G R C+GE +A+ E+FLFLA +LQR +P G + D+ Sbjct: 351 EEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGK 410 Query: 494 YGLTMKHACCEHFQMQLRS 512 +G+ ++ + ++R+ Sbjct: 411 FGVVLQPKKFK-VVAKVRA 428 >5UYS-A nrPDB Length = 494 Score = 404 bits (1038), Expect = e-113, Method: Composition-based stats. Identities = 143/459 (31%), Positives = 233/459 (50%), Gaps = 15/459 (3%) Query: 36 GLKNPPGPWGWPLIGHMLTLGKNPHLA--LSRMSQQYGDVLQIRIGSTPVVVLSGLDTIR 93 G K P PL+G + L ++ H+ ++ ++YG + +R+G+ V++ + Sbjct: 6 GAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAK 65 Query: 94 QALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPAS 153 + L+++G DF GRP + T + SN + DSG W RRL + +F++ D Sbjct: 66 EVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRL---AMATFALFKDGDQ 122 Query: 154 STSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQE 213 LE+ + +E L L + V V+VTNVI ICF Y + E Sbjct: 123 ----KLEKIICQEISTLCDMLATHNGQS--IDISFPVFVAVTNVISLICFNTSYKNGDPE 176 Query: 214 LLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTF 273 L + N N + + + D +P L+ PN +L K + + K+++ + + F Sbjct: 177 LNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKF 236 Query: 274 EKGHIRDITDSLIEH---CQEKQLDENANVQL-SDEKIINIVLDLFGAGFDTVTTAISWS 329 I ++ D+L++ + + +L SD I+ + D+FGAG +T T+ + W+ Sbjct: 237 RSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 296 Query: 330 LMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHS 389 L +L+ NP+V++K+ EE+D +G SR P +SDR+ L +EA I E R P IPH Sbjct: 297 LAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHK 356 Query: 390 TTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVII 449 D+S+ F + KG V +N W ++H++K W P +F+PERFL P G S + Sbjct: 357 ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLP 416 Query: 450 FGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKV 488 FG G R CIGE +AR E+FL +A LLQR + VP ++ Sbjct: 417 FGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQL 455 >3IBD-A nrPDB Length = 476 Score = 401 bits (1030), Expect = e-112, Method: Composition-based stats. Identities = 135/447 (30%), Positives = 230/447 (51%), Gaps = 21/447 (4%) Query: 51 HMLTLGKNPH-LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDL 109 ++L + + + R ++YGDV + +G PVV+L G++ IR+ALV + + F GR + Sbjct: 23 NLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKI 82 Query: 110 YTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEV 169 G + F+ +G W RR + ++ F + +EE + +EA+ Sbjct: 83 AMVDPFFRGYGVIFA--NGNRWKVLRRFSVTTMRDFGMGKRS-------VEERIQEEAQC 133 Query: 170 LISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVG 229 LI L++ +P N+IC+I FG+R+ + QE L ++NL ++ Sbjct: 134 LIEELRKSKG--ALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLIS 191 Query: 230 S--GNPAD-FIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLI 286 S G + F L++ P +K+L E +++ V++H +T + RD+ D+ + Sbjct: 192 SVFGQLFELFSGFLKHFPGAHRQVYKNLQE-INAYIGHSVEKHRETLDPSAPRDLIDTYL 250 Query: 287 EHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEE 346 H ++++ NA+ + S + + L LF AG +T +T + + + ++ P V ++ E Sbjct: 251 LHMEKEK--SNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYRE 308 Query: 347 LDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRC 406 ++ VIG R P L DR+ +PY EA I E R S +P +PH T+ TS +G+ IPK Sbjct: 309 IEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTE 368 Query: 407 VFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWE 466 VF+ HD + P F P+ FL +GA+ K +E I F +GKR C+GE IAR E Sbjct: 369 VFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK--TEAFIPFSLGKRICLGEGIARAE 426 Query: 467 VFLFLAILLQRVEFSVPLGVK-VDMTP 492 +FLF +LQ + P+ + +D+TP Sbjct: 427 LFLFFTTILQNFSMASPVAPEDIDLTP 453 >4R20-A nrPDB Length = 486 Score = 399 bits (1024), Expect = e-111, Method: Composition-based stats. Identities = 143/446 (32%), Positives = 225/446 (50%), Gaps = 15/446 (3%) Query: 59 PHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNG 118 PHL +++S QYG + + G +V+S + +R+ L+++G +F GRP + T L++ G Sbjct: 41 PHLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQG 100 Query: 119 QSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELM 178 D P+W RRL + F S+ L+ V + A+ L LQ Sbjct: 101 GKDIAFADYSPLWKNHRRLVHSSFTLFGEGSN-------KLQTIVQEAADSLCEELQACR 153 Query: 179 AGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIP 238 + ++ +VTNVIC + F Y + EL +++ N+ + + G D P Sbjct: 154 GQS--SDLSVVLMRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIFP 211 Query: 239 ILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENA 298 LR PN L K+ + K + EH K+ G RD+ D+L+ Q Sbjct: 212 WLRIFPNKDLKRLKECVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALLIGQQRG---SGG 268 Query: 299 NVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPR 358 ++++ ++ + FGAG +T +T + W++ +L+ +P++Q ++Q ELD +G R P Sbjct: 269 ADDITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPC 328 Query: 359 LSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQ 418 LSDR HLP ++A + E R P IPH +DTSL G +PKG V VN W I+HD Sbjct: 329 LSDRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDP 388 Query: 419 KLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 K W P +F PERFL P G K + FG G R C+GE++AR E+FLF++ LQR Sbjct: 389 KHWDQPEQFNPERFLEPSG--KKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRF 446 Query: 479 EFSVPLGVKV-DMTPIYGLTMKHACC 503 FS P + D+ +G+ ++ Sbjct: 447 SFSCPSEASLPDLQGRFGVVLQPERY 472 >6IQ5-A nrPDB Length = 463 Score = 399 bits (1024), Expect = e-111, Method: Composition-based stats. Identities = 180/447 (40%), Positives = 263/447 (58%), Gaps = 10/447 (2%) Query: 60 HLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQ 119 HL+ +R++++YGDV QIR+GS P+VVL+G I QALV+QG F RP +F ++S G+ Sbjct: 4 HLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGR 63 Query: 120 SMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMA 179 SM+F W +RR A + +++F + LE HV EA L++ L A Sbjct: 64 SMAFGH-YSEHWKVQRRAAHSMMRNF---FTRQPRSRQVLEGHVLSEARELVALLVRGSA 119 Query: 180 GPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPI 239 +P VV+V NV+ A+CFG RY H+ E L++ N FG VG+G+ D +P Sbjct: 120 DGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPW 179 Query: 240 LRYLPNPSLNAFKD---LNEKFYSFMQKMVKEHYKTFEKGH-IRDITDSLIEHCQEKQLD 295 L+Y PNP F++ LN F +F+ H ++ G RD+ D+ I ++K Sbjct: 180 LQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAG 239 Query: 296 E--NANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGR 353 + +L E + + D+FGA DT++TA+ W L+ P VQ ++Q ELD V+GR Sbjct: 240 DSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGR 299 Query: 354 SRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQ 413 R P + D+ +LPY+ AF+ E R SSFVP TIPH+TT +TS+ G++IPK VFVNQW Sbjct: 300 DRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWS 359 Query: 414 INHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAI 473 +NHD W NP F P RFL DG I+K L+ +V+IF +GKR+CIGE +++ ++FLF++I Sbjct: 360 VNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISI 419 Query: 474 LLQRVEFSVPLGVKVDMTPIYGLTMKH 500 L + +F M YGLT+K Sbjct: 420 LAHQCDFRANPNEPAKMNFSYGLTIKP 446 >3DL9-A nrPDB Length = 479 Score = 374 bits (959), Expect = e-104, Method: Composition-based stats. Identities = 120/445 (26%), Positives = 220/445 (49%), Gaps = 18/445 (4%) Query: 59 PHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNG 118 PH+ + + SQ YG++ + +G VVL+G D +++ LV Q + F RP L F ++ Sbjct: 36 PHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM 95 Query: 119 QSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELM 178 + + G W RRLA N + F E + +E + ++ Sbjct: 96 GGL-LNSRYGRGWVDHRRLAVNSFRYFGYGQKS-------FESKILEETKFFNDAIETYK 147 Query: 179 AGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPA--DF 236 P F+ + + +V+N+ I FG R+ + + ++ L + E+ S + + Sbjct: 148 GRP--FDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNA 205 Query: 237 IPILRYLP-NPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLD 295 P + LP F++ Y F+ +++++ + + D+ ++ + + D Sbjct: 206 FPWIGILPFGKHQQLFRNA-AVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKND 264 Query: 296 ENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSR 355 ++ S E +I V +L AG +T T + W+++++ + P +Q ++Q+E+D ++G + Sbjct: 265 PSST--FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNG 322 Query: 356 RPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIN 415 +P D+ +PY EA + E R + VP I H+T+ D ++G+ IPKG V N + ++ Sbjct: 323 KPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVH 382 Query: 416 HDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILL 475 D+K W +P F PERFL G K E ++ F +G+R C+GE +AR E+FLF LL Sbjct: 383 FDEKYWRDPEVFHPERFLDSSGYFAK--KEALVPFSLGRRHCLGEHLARMEMFLFFTALL 440 Query: 476 QRVEFSVPLGVKVDMTPIYGLTMKH 500 QR P + D+ P G+T++ Sbjct: 441 QRFHLHFPHELVPDLKPRLGMTLQP 465 >3TBG-A nrPDB Length = 479 Score = 367 bits (941), Expect = e-102, Method: Composition-based stats. Identities = 135/436 (30%), Positives = 228/436 (52%), Gaps = 19/436 (4%) Query: 57 KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLIS 116 +N ++ +++GDV +++ TPVVVL+GL +R+ALV G+D RP + ++ Sbjct: 30 QNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILG 89 Query: 117 NGQSM--SFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTL 174 G F GP W +RR + + L++ + LE+ V++EA L + Sbjct: 90 FGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKS-------LEQWVTEEAACLCAAF 142 Query: 175 QELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSG--N 232 P F P + +V+NVI ++ GRR++++ L L++L + Sbjct: 143 ANHSGRP--FRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLRE 200 Query: 233 PADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHI-RDITDSLIEHCQE 291 + +P+L ++P + + + F + + +++ EH T++ RD+T++ + ++ Sbjct: 201 VLNAVPVLLHIPALAGKVLR-FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEK 259 Query: 292 KQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVI 351 + N +DE + +V DLF AG T +T ++W L+ ++++P VQR++Q+E+D VI Sbjct: 260 AK--GNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVI 317 Query: 352 GRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQ 411 G+ RRP + D++H+PY A I E R VP + H T+RD ++GF IPKG + N Sbjct: 318 GQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNL 377 Query: 412 WQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFL 471 + D+ +W P F PE FL G K E + F G+R C+GE +AR E+FLF Sbjct: 378 SSVLKDEAVWEKPFRFHPEHFLDAQGHFVK--PEAFLPFSAGRRACLGEPLARMELFLFF 435 Query: 472 AILLQRVEFSVPLGVK 487 LLQ FSVP G Sbjct: 436 TSLLQHFSFSVPTGQP 451 >3QZ1-A nrPDB Length = 496 Score = 349 bits (894), Expect = 2e-96, Method: Composition-based stats. Identities = 137/476 (28%), Positives = 227/476 (47%), Gaps = 32/476 (6%) Query: 43 PWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDD 102 P P G + L N + L ++Q+ G V ++R+G VVVL+ TI +A++R+ D Sbjct: 31 PPLVP--GFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVD 88 Query: 103 FKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEH 162 F GRP + ++ L+S D +W A ++L ++ L T +E Sbjct: 89 FAGRPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSAL---------LLGTRSSMEPW 139 Query: 163 VSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLV-NLN 221 V + + ++ P ++ ++IC + FG + D V +L Sbjct: 140 VDQLTQEFCERMRVQAGAPVTIQKEFSLL--TCSIICYLTFGNKEDTLVHAFHDCVQDLM 197 Query: 222 NNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDI 281 + S D +P LR+ PNP L K E ++K ++ H ++ G RD+ Sbjct: 198 KTWDHW--SIQILDMVPFLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDM 255 Query: 282 TDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQR 341 TD +++ ++++E QL + + V+DLF G +T + +SW++ +L+ +P +QR Sbjct: 256 TDYMLQGVGRQRVEEGPG-QLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQR 314 Query: 342 KIQEELDTVIGRSR---RPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKG 398 ++QEELD +G R DR+ LP + A I E R VP +PH TTR +S+ G Sbjct: 315 RLQEELDRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFG 374 Query: 399 FYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCI 458 + IP+G V N + D+ +W P EF P+RFL P + FG G R C+ Sbjct: 375 YDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANPS------ALAFGCGARVCL 428 Query: 459 GETIARWEVFLFLAILLQRVEFSVPLG---VKVDMTPIYGLTMKHACCEHFQMQLR 511 GE++AR E+F+ LA LLQ P + P G+ +K + FQ++L+ Sbjct: 429 GESLARLELFVVLARLLQAFTLLPPPVGALPSLQPDPYCGVNLK---VQPFQVRLQ 481 >5VBU-A nrPDB Length = 476 Score = 344 bits (881), Expect = 7e-95, Method: Composition-based stats. Identities = 126/489 (25%), Positives = 226/489 (46%), Gaps = 33/489 (6%) Query: 29 SRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 88 ++ KG P P G + L + + L ++Q++G + ++ +G VVVL+ Sbjct: 2 AKKTSSKGKLPPLAP------GFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNS 55 Query: 89 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 148 TI +A+V++ DF GRP+ T+ L+S D +W A ++L ++ L Sbjct: 56 KRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSAL------ 109 Query: 149 SDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD 208 +E V + + ++ P ++ ++IC + FG + Sbjct: 110 ---LLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLL--TCSIICYLTFGDKIK 164 Query: 209 HNH---QELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKM 265 ++ + + + S D IP LR+ PNP L K EK ++ Sbjct: 165 DDNLMPAYYKCIQEVLKTWSHW--SIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQ 222 Query: 266 VKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTA 325 +++H ++ G RD+ D +++ + ++E + QL + + +DL G +T Sbjct: 223 LRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSG-QLLEGHVHMAAVDLLIGGTETTANT 281 Query: 326 ISWSLMYLVMNPRVQRKIQEELDTVIG---RSRRPRLSDRSHLPYMEAFILETFRHSSFV 382 +SW++++L+ +P +Q+++QEELD +G S R DR+ LP + A I E R V Sbjct: 282 LSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVV 341 Query: 383 PFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKV 442 P +PH TTR +S+ G+ IP+G + N + D+ +W P EF P+RFL P Sbjct: 342 PLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKN---- 397 Query: 443 LSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHAC 502 + + FG G R C+GE +AR E+F+ L LLQ + P+ ++ Sbjct: 398 --SRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVI-LK 454 Query: 503 CEHFQMQLR 511 + FQ++L+ Sbjct: 455 MQPFQVRLQ 463 >5YLW-A nrPDB Length = 495 Score = 330 bits (847), Expect = 7e-91, Method: Composition-based stats. Identities = 115/454 (25%), Positives = 205/454 (45%), Gaps = 23/454 (5%) Query: 39 NPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVR 98 PPGP+ +P++G+ML LG NPH +++S++YG ++ I +GS V++S + ++ L R Sbjct: 28 LPPGPFPYPIVGNMLQLGANPHQVFAKLSKRYGPLMSIHLGSLYTVIVSSPEMAKEILHR 87 Query: 99 QGDDFKGRPDLYTFTLISNGQ-SMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSC 157 G F GR + + SM F P + W R++ + + FS S AS Sbjct: 88 HGQVFSGRTIAQAVHACDHDKISMGFLPVASE-WRDMRKICKEQM--FSNQSMEAS---- 140 Query: 158 YLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRY-DHNHQELLS 216 + ++ + L+ +Q+ + ++ N++ A F + + + + + Sbjct: 141 --QGLRRQKLQQLLDHVQKCSDSGRAVDIREAAFITTLNLMSATLFSSQATEFDSKATME 198 Query: 217 LVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNA-----FKDLNEKFYSFMQKMVKEHYK 271 + +VG N AD+ PILR + F L K ++ + ++ Sbjct: 199 FKEIIEGVATIVGVPNFADYFPILRPFDPQGVKRRADVFFGKLLAKIEGYLNERLESKRA 258 Query: 272 TFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLM 331 D + +++ Q + +L +++LDLF G DT TT+I W++ Sbjct: 259 NPNAPKKDDFLEIVVDIIQANEF------KLKTHHFTHLMLDLFVGGSDTNTTSIEWAMS 312 Query: 332 YLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTT 391 LVMNP +++ EL +V G + S LPY++A I E R P +P Sbjct: 313 ELVMNPDKMARLKAELKSVAGDEKIVDESAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAE 372 Query: 392 RDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFG 451 D + G+ IPKG + +N + I D +W +P F PERFL + K +++ FG Sbjct: 373 SDQEVNGYLIPKGTQILINAYAIGRDPSIWTDPETFDPERFLD-NKIDFKGQDYELLPFG 431 Query: 452 MGKRKCIGETIARWEVFLFLAILLQRVEFSVPLG 485 G+R C G +A + + A L+ ++ + Sbjct: 432 SGRRVCPGMPLATRILHMATATLVHNFDWKLEDD 465 >6DA2-A nrPDB Length = 487 Score = 308 bits (789), Expect = 3e-84, Method: Composition-based stats. Identities = 103/476 (21%), Positives = 182/476 (38%), Gaps = 23/476 (4%) Query: 41 PGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQ- 99 PGP P +G++L+ K + ++YG V G PV+ ++ D I+ LV++ Sbjct: 19 PGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKEC 78 Query: 100 GDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYL 159 F R F + +S + S W R L S + Sbjct: 79 YSVFTNRR---PFGPVGFMKS-AISIAEDEEWKRLRSLLSPTFT---------SGKLKEM 125 Query: 160 EEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVN 219 +++ +VL+ L+ +VI + FG D + V Sbjct: 126 VPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVE 185 Query: 220 LNN---NFGEVVGSGNPADFIPIL-RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEK 275 F + P L L ++ F F K +KE + Sbjct: 186 NTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQ 245 Query: 276 GHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVM 335 H D +I+ K+ + ++ LSD +++ + AG++T ++ +S+ + L Sbjct: 246 KHRVDFLQLMIDSQNSKETE--SHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT 303 Query: 336 NPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTS 395 +P VQ+K+QEE+D V+ P + Y++ + ET R + + +D Sbjct: 304 HPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDVE 362 Query: 396 LKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKR 455 + G +IPKG V + + ++ D K W P +FLPERF + D + FG G R Sbjct: 363 INGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK--DNIDPYIYTPFGSGPR 420 Query: 456 KCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLR 511 CIG A + L L +LQ F ++ + G ++ +++ R Sbjct: 421 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 476 >2WX2-A nrPDB Length = 473 Score = 307 bits (785), Expect = 1e-83, Method: Composition-based stats. Identities = 91/467 (19%), Positives = 180/467 (38%), Gaps = 45/467 (9%) Query: 29 SRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQY-GDVLQIRIGSTPVVVLS 87 +RP P P P P +GH++ GKNP + R + V I IG V ++ Sbjct: 13 TRPTDP-----PVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVG 67 Query: 88 GLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSI 147 + + + R ++YT G+ ++++ P R +L +F Sbjct: 68 DPHEHSRFFSPRNEILSPR-EVYTIMTPVFGEGVAYAA---PYPRMREQL------NFLA 117 Query: 148 ASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRY 207 + ++ + + + +E G N + N C FG Sbjct: 118 EELTIAKFQNFVPAIQHEVRKFMAENWKE---DEGVINLLEDCGAMIINTACQCLFG--- 171 Query: 208 DHNHQELLSLVNLNNNFGEVVGSGNPAD-FIPILRYLPNPSLNAFKDLNEKFYSFMQKMV 266 + ++ L+ + ++ S PA F+P L LP P ++ + + +++ Sbjct: 172 -EDLRKRLNARHFAQLLSKMESSLIPAAVFMPWLLRLPLPQSARCREARAELQKILGEII 230 Query: 267 --KEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTT 324 +E + + + D+ L++ ++S ++ +++ AG T T Sbjct: 231 VAREKEEASKDNNTSDLLGGLLKAVYRD------GTRMSLHEVCGMIVAAMFAGQHTSTI 284 Query: 325 AISWSLMYLVM--NPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFV 382 SWS+++L+ N + K+ +E+D + + D +P+ E + E+ R + Sbjct: 285 TTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYDNVMD--EMPFAERCVRESIRRDPPL 342 Query: 383 PFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKV 442 + + + + +PKG + + +HD++ + NP + PER DGA Sbjct: 343 -LMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGA---- 397 Query: 443 LSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVD 489 I FG G KCIG+ A +V LA + +F + D Sbjct: 398 ----FIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPD 440 >3JUS-A nrPDB Length = 461 Score = 304 bits (779), Expect = 4e-83, Method: Composition-based stats. Identities = 100/463 (21%), Positives = 189/463 (40%), Gaps = 39/463 (8%) Query: 29 SRPQVPKGLKNPPGPW-GWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLS 87 ++ +P G+K+PP + P +GH + GK+P L ++YG V + L Sbjct: 2 AKKTLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLL 61 Query: 88 GLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSI 147 G D + +D T G+ +++ + PV+ ++++ ++GL Sbjct: 62 GSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPN-PVFLEQKKMLKSGLN---- 116 Query: 148 ASDPASSTSCYLEEHVS---KEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFG 204 + ++HVS KE + + E G + ++ +T C Sbjct: 117 --------IAHFKQHVSIIEKETKEYFESWGES--GEKNVFEALSELIILTASHCLHGKE 166 Query: 205 RRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQK 264 R N + +L+ F A +P +LP PS + + K Sbjct: 167 IRSQLNEKVAQLYADLDGGFSHA------AWLLP--GWLPLPSFRRRDRAHREIKDIFYK 218 Query: 265 MVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTT 324 +++ ++ EK I DI +L++ + L+D+++ +++ L AG T +T Sbjct: 219 AIQKRRQSQEK--IDDILQTLLDATYKD------GRPLTDDEVAGMLIGLLLAGQHTSST 270 Query: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDR-SHLPYMEAFILETFRHSSFVP 383 +W +L + +Q+K E TV G + P D+ L ++ I ET R + Sbjct: 271 TSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIM 330 Query: 384 FTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVL 443 + + T T + G+ IP G V V+ + WV +F P+R+L + A + Sbjct: 331 IMMRMARTPQT-VAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKF 389 Query: 444 SEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGV 486 + FG G+ +CIGE A ++ + +L+ EF + G Sbjct: 390 --AYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGY 430 >5VEU-A nrPDB Length = 480 Score = 303 bits (776), Expect = 1e-82, Method: Composition-based stats. Identities = 105/447 (23%), Positives = 178/447 (39%), Gaps = 26/447 (5%) Query: 41 PGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQ- 99 PGP PL+G++L+ + + ++YG + G PV+ ++ D IR LV++ Sbjct: 18 PGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKEC 77 Query: 100 GDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYL 159 F R + + +S + S W R L S + Sbjct: 78 YSVFTNRR---SLGPVGFMKS-AISLAEDEEWKRIRSLLSPTFT---------SGKLKEM 124 Query: 160 EEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVN 219 +++ +VL+ L+ +VI FG D + V Sbjct: 125 FPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVE 184 Query: 220 LNNNFGEVVGSGNPADFIPILRYLPNPSLNAFK--DLNEKFYSFMQKMVKEHYKTF---E 274 F + G +P IL P A + +F+ K V K+ + Sbjct: 185 STKKFLKF-GFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDK 243 Query: 275 KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 334 + H D +I+ K+ + ++ LSD ++ + AG++T ++ +S++L L Sbjct: 244 QKHRLDFLQLMIDSQNSKETE--SHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELA 301 Query: 335 MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDT 394 +P VQ+K+Q+E+D V+ P + Y++ + ET R V + + +D Sbjct: 302 THPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFP-VAIRLERTCKKDV 360 Query: 395 SLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGK 454 + G +IPKG V + + ++HD K W P EF PERF +ID FG G Sbjct: 361 EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID---PYIYTPFGTGP 417 Query: 455 RKCIGETIARWEVFLFLAILLQRVEFS 481 R CIG A + L L +LQ F Sbjct: 418 RNCIGMRFALMNMKLALIRVLQNFSFK 444 >3L4D-A nrPDB Length = 453 Score = 301 bits (770), Expect = 6e-82, Method: Composition-based stats. Identities = 86/479 (17%), Positives = 179/479 (37%), Gaps = 40/479 (8%) Query: 35 KGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQ 94 KG P P +GH++ GK+P + + ++YG + + I + V+ + + Sbjct: 1 KGKLPPVVHGTTPFVGHIIQFGKDPLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQHSK 60 Query: 95 ALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASS 154 + + R ++Y+F + G+ ++++ P + L Sbjct: 61 FFTPRNEILSPR-EVYSFMVPVFGEGVAYAAPY-PRMREQLNFLAEELT----------- 107 Query: 155 TSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQEL 214 + + S + EV G N + N C FG + ++ Sbjct: 108 VAKFQNFAPSIQHEVRKFMKANWNKDEGEINILDDCSAMIINTACQCLFG----EDLRKR 163 Query: 215 LSLVNLNNNFGEVVGSGNPAD-FIPILRYLPNPSLNAFKDLNEKFYSFMQKMV--KEHYK 271 L ++ PA F+P + LP P +D + + +++ +E + Sbjct: 164 LDARQFAQLLAKMESCLIPAAVFLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEE 223 Query: 272 TFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLM 331 + + D+ L+ ++S ++ +++ AG T T +WSL+ Sbjct: 224 AQKDTNTSDLLAGLLGAVYRD------GTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLL 277 Query: 332 YLV--MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHS 389 +L+ N R K+ +E+D + + +P+ E E+ R + + Sbjct: 278 HLMDPRNKRHLAKLHQEIDEFPAQLNYDNVM--EEMPFAEQCARESIRRDPPL-VMLMRK 334 Query: 390 TTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVII 449 + + + +P+G + + + D++ + NP E+ PER + K++ Sbjct: 335 VLKPVQVGKYVVPEGDIIACSPLLSHQDEEAFPNPREWNPERNM-------KLVDGAFCG 387 Query: 450 FGMGKRKCIGETIARWEVFLFLAILLQRVEFSV--PLGVKVDMTPIYGLTMKHACCEHF 506 FG G KCIGE +V LA +L+ +F + PL T + G T ++ Sbjct: 388 FGAGVHKCIGEKFGLLQVKTVLATVLRDYDFELLGPLPEPNYHTMVVGPTASQCRVKYI 446 >5FSA-A nrPDB Length = 490 Score = 298 bits (763), Expect = 3e-81, Method: Composition-based stats. Identities = 97/503 (19%), Positives = 180/503 (35%), Gaps = 52/503 (10%) Query: 37 LKNPPGPWGW-PLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQA 95 K PP + W P G + G+ P+ Q+YGDV + + V G Sbjct: 3 KKTPPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFV 62 Query: 96 LVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASST 155 + D T G + + + R + Q F++ +D Sbjct: 63 FNAKLSDVSAEEAYKHLTTPVFGTGVIYDCPNS------RLMEQKKFAKFALTTDSFKRY 116 Query: 156 SCYLEEHVSKE-AEVLISTLQELMAGPGHFNPY--RYVVVSVTNVICAICFGRRYDHNHQ 212 + E + L+E G + + + + + R +D + Sbjct: 117 VPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFA 176 Query: 213 ELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKT 272 +L S +L+ F P +F+ LP P +K + K +K + Sbjct: 177 QLYS--DLDKGF-------TPINFV--FPNLPLPHYWRRDAAQKKISATYMKEIKLRRER 225 Query: 273 FEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMY 332 + RD+ DSL+ H K V+++D++I N+++ + G T + +W L++ Sbjct: 226 GDIDPNRDLIDSLLIHSTYKD-----GVKMTDQEIANLLIGILMGGQHTSASTSAWFLLH 280 Query: 333 LVMNPRVQRKIQEELDTVI----GRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPH 388 L P +Q I +E+ ++ G D LP + I ET R + +I Sbjct: 281 LGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPL-HSIFR 339 Query: 389 STTRDTSL--KGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPD---------- 436 T + + +PKG V V+ + ++ + NP +F P R+ T Sbjct: 340 KVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNS 399 Query: 437 --------GAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKV 488 G + K +S + FG G+ +CIGE A ++ L + + +++ G KV Sbjct: 400 SDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTI-DGYKV 458 Query: 489 DMTPIYGLTMKHACCEHFQMQLR 511 + + + R Sbjct: 459 PDPDYSSMVVLPTEPAEIIWEKR 481 >4WMZ-A nrPDB Length = 539 Score = 295 bits (756), Expect = 3e-80, Method: Composition-based stats. Identities = 90/495 (18%), Positives = 175/495 (35%), Gaps = 47/495 (9%) Query: 40 PPGPWGW-PLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVR 98 PP + W P +G + G P+ ++YGD+ + + V G Sbjct: 56 PPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNA 115 Query: 99 QGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCY 158 + D T G+ + + + R + Q ++ + S Sbjct: 116 KLADVSAEAAYAHLTTPVFGKGVIYDCPNS------RLMEQKKFVKGALTKEAFKSYVPL 169 Query: 159 LEEHVSKE-AEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSL 217 + E V K + L E G + + T + R + Sbjct: 170 IAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLY 229 Query: 218 VNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEK---FYSFMQKMVKEHYKTFE 274 +L+ F PI PN L ++ + ++KE K + Sbjct: 230 SDLDKG------------FTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNND 277 Query: 275 KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 334 RD+ DSL+++ K V+++D++I N+++ + G T +W L++L Sbjct: 278 IQD-RDLIDSLMKNSTYKD-----GVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLA 331 Query: 335 MNPRVQRKIQEELDTVIGRSRRPRLSD-RSHLPYMEAFILETFRHSSFVPFTIPHSTTRD 393 P VQ+++ EE V+ ++ D +P + I ET R + ++ +D Sbjct: 332 ERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPL-HSLFRKVMKD 390 Query: 394 TSLKG--FYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPD--------------G 437 + + IP G V V+ + + + N +F R+ G Sbjct: 391 MHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFG 450 Query: 438 AIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLT 497 AI K +S + FG G+ +CIGE A ++ + ++I ++ +++ P G V + Sbjct: 451 AISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMV 510 Query: 498 MKHACCEHFQMQLRS 512 + R+ Sbjct: 511 TLPTGPAKIIWEKRN 525 >6AYB-A nrPDB Length = 466 Score = 294 bits (753), Expect = 5e-80, Method: Composition-based stats. Identities = 102/457 (22%), Positives = 181/457 (39%), Gaps = 31/457 (6%) Query: 29 SRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 88 ++ KG P P P +G ++ KNP + S++YGDV I + L+ Sbjct: 2 AKKTSSKGKLPPRVPNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFLNH 61 Query: 89 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKS--FS 146 + ++ R D+Y F G + + DS + + +GL + F Sbjct: 62 PKILDTFFKATDNELSLR-DVYRFMRPVFGTGVVYDADSTERMMEQVKFVSSGLTTARFR 120 Query: 147 IASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRR 206 + D + + + E V ++ L ++ T C + R Sbjct: 121 VFVDIFEDEIAHKVKELGPEGTVDVAELM-------------ADLIIFTASRCLLGDEVR 167 Query: 207 YDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLN-AFKDLNEKFYSFMQKM 265 + LS NL + ++ +P F LP P + A K + E F + K Sbjct: 168 ------QYLSEKNLGKLYHDIDDGISPLSF--FYPSLPAPKRDKARKAVGEIFQELLDKR 219 Query: 266 VKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTA 325 +EH K E+ D +++H ++ + +L+D I I++ AG T + Sbjct: 220 REEHKKHPERLLDESKMD-VVDHLLTQKYKDGQ--ELTDVHRIGILIAGLFAGQHTSSIT 276 Query: 326 ISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFT 385 SW+LM ++ N +V K+++E + ++G + + Y+EA + E R + Sbjct: 277 SSWTLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPL-IM 335 Query: 386 IPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSE 445 I + + + IPKG + V+ + NP F PER LT +K Sbjct: 336 IMRMARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPER-LTERKEHEK-FKY 393 Query: 446 KVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSV 482 + FG G+ KCIGE A +V ++ILL+ + Sbjct: 394 GAVPFGAGRHKCIGENFALLQVKSIISILLRYFDMEY 430 >6CR2-A nrPDB Length = 477 Score = 293 bits (749), Expect = 2e-79, Method: Composition-based stats. Identities = 87/472 (18%), Positives = 165/472 (34%), Gaps = 50/472 (10%) Query: 37 LKNPPGPWGW-PLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQA 95 K PP + W P IG ++ G +P+ +YGD+ + V G Sbjct: 3 KKTPPVVFHWFPFIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGNDFI 62 Query: 96 LVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASST 155 L + D T G+ + + + + + Q + + SD S Sbjct: 63 LNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNA------KLMEQKKFVKYGLTSDALRSY 116 Query: 156 SCYLEEHVSKEAEVLISTLQELMAGPGHFNPY----RYVVVSVTNVICAICFGRRYDHNH 211 ++ E E + G F+ + + + + ++D Sbjct: 117 VPL----ITDEVESFVKNSPAFQGHKGVFDVCKTIAEITIYTASRSLQGKEVRSKFDSTF 172 Query: 212 QELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYK 271 EL NL+ F P +F+ L + P P K +++K + Sbjct: 173 AELYH--NLDMGFA-------PINFM--LPWAPLPHNRKRDAAQRKLTETYMEIIKARRQ 221 Query: 272 TFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLM 331 K D+ +L+ + + DE+I ++++ L AG + ++ SW ++ Sbjct: 222 AGSKKDSEDMVWNLMSCVYK------NGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVL 275 Query: 332 YLVMNPRVQRKIQEELDTVIGRSRRPRLSD-RSHLPYMEAFILETFRHSSFVPFTIPHST 390 L P + ++ +E V+G P D L I ET R + + +I + Sbjct: 276 RLATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPI-HSIIRAV 334 Query: 391 TRDTSLKG--FYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT-------------- 434 ++ G + IP V + ++ + NP E+ P R+ Sbjct: 335 KNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVDY 394 Query: 435 PDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGV 486 G + K + + FG G+ +CIGE A ++ A+L++ F GV Sbjct: 395 GYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPGV 446 >5JLC-A nrPDB Length = 515 Score = 288 bits (737), Expect = 3e-78, Method: Composition-based stats. Identities = 84/491 (17%), Positives = 175/491 (35%), Gaps = 52/491 (10%) Query: 40 PPGPWGW-PLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVR 98 PP + W P +G + G P+ ++YGD+ + + V G Sbjct: 38 PPLVFYWIPWVGSAIPYGTKPYEFFEDCQKKYGDIFSFMLLGRIMTVYLGPKGHEFIFNA 97 Query: 99 QGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCY 158 + D T G+ + + + R + Q ++ + Sbjct: 98 KLADVSAEAAYSHLTTPVFGKGVIYDCPN------HRLMEQKKFVKGALTKEAFVRYVPL 151 Query: 159 LEEHVSKEAE-VLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSL 217 + E + K + E +G + + T + R + Sbjct: 152 IAEEIYKYFRNSKNFKINENNSGIVDVMVSQPEMTIFTASRSLLGKEMRDKLDTDFAYLY 211 Query: 218 VNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSF---MQKMVKEHYKTFE 274 +L+ F PI PN L ++ + + ++KE + + Sbjct: 212 SDLDKG------------FTPINFVFPNLPLEHYRKRDHAQQAISGTYMSLIKERREKND 259 Query: 275 KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 334 + RD+ D L+++ K +++D++I N+++ + G T +W L++L Sbjct: 260 IQN-RDLIDELMKNSTYKD-----GTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLA 313 Query: 335 MNPRVQRKIQEELDTVIGRS-RRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRD 393 P VQ ++ +E V+ + D ++P + I ET R + ++ RD Sbjct: 314 ERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPL-HSLFRKVMRD 372 Query: 394 TSLKG--FYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPD--------------- 436 ++ + +P+ V V+ + ++ + P+EF R+ Sbjct: 373 VAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGF 432 Query: 437 GAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLG----VKVDMTP 492 GAI K +S + FG G+ +CIGE A ++ + ++I ++ +++ P D T Sbjct: 433 GAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTEGETVPPSDFTS 492 Query: 493 IYGLTMKHACC 503 + L A Sbjct: 493 MVTLPTAPAKI 503 >3K9V-A nrPDB Length = 482 Score = 274 bits (701), Expect = 5e-74, Method: Composition-based stats. Identities = 100/466 (21%), Positives = 198/466 (42%), Gaps = 45/466 (9%) Query: 41 PGPWGWPLIGHMLTLG-----KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQA 95 PGP WPL+G +L + K H L+ ++YG + ++++GS V L G ++ +A Sbjct: 27 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEA 85 Query: 96 LVRQGDDFKGRPDLYTFTLISNGQSMSFSPD--SGPVWAARRRLAQNGLKSFSIASDPAS 153 L R R ++ + + ++ ++ G W R Q L Sbjct: 86 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMK--------P 137 Query: 154 STSCYLEEHVSKEAEVLISTLQELMAGPGHF-NPYRYVVVSVTNVICAICFGRRY----D 208 L++ +++ + + EL G + Y + IC + + +R+ Sbjct: 138 VEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQK 197 Query: 209 HNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKE 268 +E L+ + ++ + P+ K LN K + Sbjct: 198 ETEEEALTFITAIKT---MMSTFGKMMVTPV---------ELHKRLNTKVWQAHTLAWDT 245 Query: 269 HYKTFEKGHIRDITDSLIEHCQEKQLDENANV----QLSDEKIINIVLDLFGAGFDTVTT 324 +K+ + I + L + Q+ D ++ LS +++ V +L A +T Sbjct: 246 IFKSVKPC----IDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTAN 301 Query: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPF 384 ++ W L L NP+ QR++ +E+ +V+ ++ PR D ++PY++A + E+ R + VPF Sbjct: 302 SLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPF 361 Query: 385 TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLS 444 T + + T L + +PKG + +N + + + + +F PER+L + K+ Sbjct: 362 TT-RTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKE---KKINP 417 Query: 445 EKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDM 490 + FG+GKR CIG +A ++ L L ++Q+ + V+M Sbjct: 418 FAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEM 463 >2W0A-A nrPDB Length = 455 Score = 274 bits (701), Expect = 6e-74, Method: Composition-based stats. Identities = 85/439 (19%), Positives = 167/439 (38%), Gaps = 32/439 (7%) Query: 50 GHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDL 109 GH+ +P + R+ + GDV ++ VV+LSG + R GDD + Sbjct: 17 GHLEEFRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHA-NEFFFRAGDDDLDQAKA 75 Query: 110 YTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEV 169 Y F G+++ F R+ + N ++ + + +E+ V + Sbjct: 76 YPFMTPIFGEAVVFDAS----PERRKEMLHNA----ALRGEQMKGHAATIEDQVRR---- 123 Query: 170 LISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVG 229 +I+ E AG + + T+ C I G+++ + E+ Sbjct: 124 MIADWGE--AGEIDLLDFFAELTIYTSSACLI--GKKFRDQLDGR-----FAKLYHELER 174 Query: 230 SGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTF-EKGHIRDITDSLIEH 288 +P ++ YLP S + + + ++ RD+ D LI Sbjct: 175 GTDPLAYVD--PYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLI-- 230 Query: 289 CQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELD 348 E + S ++I + + + AG T + SW+L+ L+ + + +ELD Sbjct: 231 ---AVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELD 287 Query: 349 TVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVF 408 + G R +P +E + ET R + + + ++G I +G V Sbjct: 288 ELYGDGRSVSFHALRQIPQLENVLKETLRLHPPL-IILMRVAKGEFEVQGHRIHEGDLVA 346 Query: 409 VNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVF 468 + N + + +P +F+P R+ P D + I FG G+ +C+G A ++ Sbjct: 347 ASPAISNRIPEDFPDPHDFVPARYEQPRQE-DLLNRWTWIPFGAGRHRCVGAAFAIMQIK 405 Query: 469 LFLAILLQRVEFSVPLGVK 487 ++LL+ EF + + Sbjct: 406 AIFSVLLREYEFEMAQPPE 424 >2X2N-A nrPDB Length = 475 Score = 272 bits (696), Expect = 2e-73, Method: Composition-based stats. Identities = 80/467 (17%), Positives = 170/467 (36%), Gaps = 45/467 (9%) Query: 29 SRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQY-GDVLQIRIGSTPVVVLS 87 +RP P P P P++GH++ GK+P + +Q + I I V ++ Sbjct: 13 TRPTDP-----PVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVG 67 Query: 88 GLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSI 147 + + + + R ++Y+F + G+ ++++ P + + Sbjct: 68 DPHEHSRFFLPRNEVLSPR-EVYSFMVPVFGEGVAYAAPY-PRMREQLNF---------L 116 Query: 148 ASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRY 207 A + + + E ++ G N + N C FG Sbjct: 117 AEELTIAKFQNFVPAIQHEVRKFMAA--NWDKDEGEINLLEDCSTMIINTACQCLFG--- 171 Query: 208 DHNHQELLSLVNLNNNFGEVVGSGNPAD-FIPILRYLPNPSLNAFKDLNEKFYSFMQKMV 266 + ++ L ++ S PA F+PIL LP P + + + +++ Sbjct: 172 -EDLRKRLDARRFAQLLAKMESSLIPAAVFLPILLKLPLPQSARCHEARTELQKILSEII 230 Query: 267 --KEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTT 324 ++ + D+ L+ +S ++ +++ AG T + Sbjct: 231 IARKAAAVNKDSSTSDLLSGLLSAVYRD------GTPMSLHEVCGMIVAAMFAGQHTSSI 284 Query: 325 AISWSLMYLVM--NPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFV 382 +WS+++L+ N + +++E++ + + D +P+ E E+ R + Sbjct: 285 TTTWSMLHLMHPANVKHLEALRKEIEEFPAQLNYNNVMD--EMPFAERCARESIRRDPPL 342 Query: 383 PFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKV 442 + D + + +PKG + + +HD++ + P + PER +GA Sbjct: 343 -LMLMRKVMADVKVGSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPERDEKVEGA---- 397 Query: 443 LSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVD 489 I FG G KCIG+ +V LA + +F + D Sbjct: 398 ----FIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQLLRDEVPD 440 >6C94-A nrPDB Length = 497 Score = 271 bits (693), Expect = 4e-73, Method: Composition-based stats. Identities = 100/486 (20%), Positives = 182/486 (37%), Gaps = 48/486 (9%) Query: 41 PGPWGWPLIGHMLTLGKNPHL-ALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQ 99 PGP L GH L + K L + +QQ+ + +G + +A+ + Sbjct: 25 PGPPTHWLFGHALEIQKTGSLDKVVTWTQQFPYAHPLWVGQFIGFLNIYEPDYAKAVYSR 84 Query: 100 GDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYL 159 GD PD+Y F L G+ + GP W R+L G D Sbjct: 85 GD--PKAPDVYDFFLQWIGKGL--LVLDGPKWFQHRKLLTPGFHY-----DVLKPYVAIF 135 Query: 160 EEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGR-------------- 205 + +++ ++ F+ + V + + FG+ Sbjct: 136 ADS----TRIMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSYYV 191 Query: 206 ---RYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFM 262 Q+ + +N+F + + + F+ R + + + Sbjct: 192 AVSELTLLMQQRIDSFQYHNDFIYWL-TPHGRRFLRACRAAHDHTDRVIRQRKAALQDE- 249 Query: 263 QKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTV 322 KE K + H+ D D L++ + + VQLSD + V G DT Sbjct: 250 ----KEREKIQNRRHL-DFLDILLD------VRGESGVQLSDTDLRAEVDTFMFEGHDTT 298 Query: 323 TTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFV 382 T+ ISW L + + P Q++ +EE+ ++G + D + + Y+ + E FR V Sbjct: 299 TSGISWFLYCMALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPV 358 Query: 383 PFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKV 442 P + + + G +P G + ++ + ++ + +W +P F P RF + + Sbjct: 359 PQVYRQLSKPVSFVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRH- 417 Query: 443 LSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSV-PLGVKVDMTPIYGLTMKHA 501 I F G R CIG+ A E+ + A+ L R EFSV PL + + + P L K+ Sbjct: 418 -PYAFIPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSVDPLRLPIKL-PQLVLRSKNG 475 Query: 502 CCEHFQ 507 + + Sbjct: 476 IHLYLK 481 >2VE3-A nrPDB Length = 444 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 99/466 (21%), Positives = 187/466 (40%), Gaps = 46/466 (9%) Query: 29 SRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 88 + P L PPG +G P +G L + R QQ+G + + R+ V+ +SG Sbjct: 3 TSPTNLNSLPIPPGDFGLPWLGETLNFLNDGDFGKKR-QQQFGPIFKTRLFGKNVIFISG 61 Query: 89 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 148 R ++ + F+ L T L+ + + G + +RR++ ++ Sbjct: 62 ALANRFLFTKEQETFQATWPLSTRILLGPN---ALATQMGEIHRSRRKILYQAFLPRTLD 118 Query: 149 S---DPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGR 205 S YLE+ K EV+ Y + +V + G Sbjct: 119 SYLPKMDGIVQGYLEQW-GKANEVIW---------------YPQLRRMTFDVAATLFMGE 162 Query: 206 RYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKM 265 + N Q L + + + S LPN + + ++K+ Sbjct: 163 KVSQNPQ----LFPWFETYIQGLFSLPI--------PLPNTLFGKSQRARALLLAELEKI 210 Query: 266 VKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTA 325 +K + + D L+ ++ N LS ++ + +L L AG +T+T+A Sbjct: 211 IKARQQ--QPPSEEDALGILLAA------RDDNNQPLSLPELKDQILLLLFAGHETLTSA 262 Query: 326 ISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFT 385 +S + L + ++ ++++E + + S+ +PY++ + E R V Sbjct: 263 LSSFCLLLGQHSDIRERVRQEQNK-LQLSQELTAETLKKMPYLDQVLQEVLRLIPPVGGG 321 Query: 386 IPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSE 445 +D +GF+ PKG V Q + D L+ +P +F PERF TPDG+ Sbjct: 322 F-RELIQDCQFQGFHFPKGWLVSYQISQTHADPDLYPDPEKFDPERF-TPDGSATHNPPF 379 Query: 446 KVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMT 491 + FG G R+C+G+ AR E+ LF L+Q+ ++++ G +++ Sbjct: 380 AHVPFGGGLRECLGKEFARLEMKLFATRLIQQFDWTLLPGQNLELV 425 >3EL3-A nrPDB Length = 467 Score = 260 bits (664), Expect = 1e-69, Method: Composition-based stats. Identities = 97/453 (21%), Positives = 182/453 (40%), Gaps = 32/453 (7%) Query: 29 SRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 88 + P P+ + P G PL+GH L ++P +S++ +GDV++I++G V ++ Sbjct: 14 AAPGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQLR-DHGDVVRIKLGPKTVYAVTN 72 Query: 89 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 148 + + AL D P + + + ++ + +GP+ +RR Q F + Sbjct: 73 PE-LTGALALNPDYHIAGPLWESLEGLLGKEGVATA--NGPLHRRQRRTIQPA---FRLD 126 Query: 149 SDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD 208 + PA + +EA L Q PG V + A C R Sbjct: 127 AIPAYGP------IMEEEAHALTERWQ-----PGKTVDATSESFRVAVRVAARCL-LRGQ 174 Query: 209 HNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKE 268 + + L + P+ R LP P+ F D + + +++ E Sbjct: 175 YMDERAERLCVALATVFRGMYRRMVVPLGPLYR-LPLPANRRFNDALADLHLLVDEIIAE 233 Query: 269 HYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISW 328 + +K D+ +L+E ++ + +++I + V+ + G +T+ + I W Sbjct: 234 RRASGQK--PDDLLTALLEA------KDDNGDPIGEQEIHDQVVAILTPGSETIASTIMW 285 Query: 329 SLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPH 388 L L +P +I++E++ V G R D L + I+E R V + + Sbjct: 286 LLQALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAV-WVLTR 343 Query: 389 STTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVI 448 ++ L G+ IP G + + + I D K + + EF P+R+L A V + Sbjct: 344 RAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAA--NVPKYAMK 401 Query: 449 IFGMGKRKCIGETIARWEVFLFLAILLQRVEFS 481 F GKRKC + + ++ L A L + F Sbjct: 402 PFSAGKRKCPSDHFSMAQLTLITAALATKYRFE 434 >3MDV-A nrPDB Length = 456 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 83/441 (18%), Positives = 170/441 (38%), Gaps = 35/441 (7%) Query: 63 LSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVR---QGDDFKGRPDLYTFTLISNGQ 119 +++YG V+++ + V+++ +++++ L+ D R F GQ Sbjct: 16 FLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ 75 Query: 120 SMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMA 179 + + W +RR+ S+ L E +++AE L+ L+ Sbjct: 76 GLVSECNY-ERWHKQRRVIDLAFS---------RSSLVSLMETFNEKAEQLVEILEAKAD 125 Query: 180 GPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPI 239 G + + + +++ FG LL + +++ G A + Sbjct: 126 GQTPVSMQDMLTYTAMDILAKAAFGM----ETSMLLGAQKPLSQAVKLMLEGITASRNTL 181 Query: 240 LRYLPNP--SLNAFKDLNEKFYSFMQKMVKEHYKTFEKGH--IRDITDSLIEHCQEKQLD 295 ++LP L ++ + V+ + ++G DI +++ + Q Sbjct: 182 AKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQ-- 239 Query: 296 ENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSR 355 DE +++ + F AG +T +++++M L P + ++Q E+D VIG R Sbjct: 240 -------DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKR 292 Query: 356 RPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIN 415 D L Y+ + E+ R + +T + G +P + + + + Sbjct: 293 YLDFEDLGRLQYLSQVLKESLRLYPPA-WGTFRLLEEETLIDGVRVPGNTPLLFSTYVMG 351 Query: 416 HDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILL 475 + +P F P+RF G F +G R CIG+ A+ EV + +A LL Sbjct: 352 RMDTYFEDPLTFNPDRF----GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLL 407 Query: 476 QRVEFSVPLGVKVDMTPIYGL 496 QR+EF + G + + L Sbjct: 408 QRLEFRLVPGQRFGLQEQATL 428 >4KPA-A nrPDB Length = 494 Score = 205 bits (520), Expect = 6e-53, Method: Composition-based stats. Identities = 100/484 (20%), Positives = 176/484 (36%), Gaps = 43/484 (8%) Query: 37 LKNPPGPWGWPLIGHMLTLGKN-PHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQA 95 +K P P + + ++ L + P AL +++ + G++ + LS I++A Sbjct: 26 IKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEA 85 Query: 96 LVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASST 155 + K F G + S W + Sbjct: 86 -CDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFS-----QQAMKGY 139 Query: 156 SCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRY-----DHN 210 + + A L+ + L A H + + I F R+ D Sbjct: 140 HAMMVDI----AVQLVQKWERLNADE-HIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQP 194 Query: 211 HQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHY 270 H + S+V + + NP D + + F++ + + K++ + Sbjct: 195 HPFITSMVRALDEAMNKLQRANPDD------PAYDENKRQFQEDIKVMNDLVDKIIADRK 248 Query: 271 KTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330 + E+ D L+ H + D L DE I ++ AG +T + +S++L Sbjct: 249 ASGEQS------DDLLTHMLNGK-DPETGEPLDDENIRYQIITFLIAGHETTSGLLSFAL 301 Query: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390 +LV NP V +K EE V+ P L Y+ + E R P Sbjct: 302 YFLVKNPHVLQKAAEEAARVL-VDPVPSYKQVKQLKYVGMVLNEALRLWPTAP-AFSLYA 359 Query: 391 TRDTSLKG-FYIPKGRCVFVNQWQINHDQKLW-VNPSEFLPERFLTPDGAIDKVLSEKVI 448 DT L G + + KG + V Q++ D+ +W + EF PERF P + Sbjct: 360 KEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSA----IPQHAFK 415 Query: 449 IFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQM 508 FG G+R CIG+ A E L L ++L+ +F ++D+ LT+K E F + Sbjct: 416 PFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKET--LTLKP---EGFVV 470 Query: 509 QLRS 512 + +S Sbjct: 471 KAKS 474 >3N9Z-A nrPDB Length = 487 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 82/480 (17%), Positives = 170/480 (35%), Gaps = 24/480 (5%) Query: 28 ASRPQVPKGLKNPPGPWGWPLIGHMLTLG--KNPHLALSRMSQQYGDVLQIRIGSTPVVV 85 ++R P PG GW + H HL + Q+YG + + ++G+ V Sbjct: 1 STRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVY 60 Query: 86 LSGLDTIRQALVRQGDDFKGRPDLYTFTLISNG--QSMSFSPDSGPVWAARRRLAQNGLK 143 + + + +G + R + + + + W R L Sbjct: 61 VIDPEDVALLFKSEGPN-PERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDR----VALN 115 Query: 144 SFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICF 203 +A + + L+ VL +++ +G + + I + F Sbjct: 116 QEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIF 175 Query: 204 GRRYDHNHQELLSLVNLN-NNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFM 262 G R + + + ++ + P + LP F+ K + Sbjct: 176 GERQGMLEEVVNPEAQRFIDAIYQMFHTSVP------MLNLPPDLFRLFRTKTWKDHVAA 229 Query: 263 QKMVKEHYKTFEKGHIRDITDSLIEHCQEKQ--LDENANVQLSDEKIINIVLDLFGAGFD 320 ++ + + ++ H + + ++S E I V ++ G D Sbjct: 230 WDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVD 289 Query: 321 TVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSS 380 T + + W L + N +VQ ++ E+ +++ + +P ++A I ET R Sbjct: 290 TTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHP 349 Query: 381 FVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAID 440 + T+ D L+ + IP V V + + + + +P F P R+L+ D I Sbjct: 350 -ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNIT 408 Query: 441 KVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKH 500 + + FG G R+C+G IA E+ +FL +L+ V + D+ + L + Sbjct: 409 YF---RNLGFGWGVRQCLGRRIAELEMTIFLINMLENFR--VEIQHLSDVGTTFNLILMP 463 >3MZS-A nrPDB Length = 486 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 81/487 (16%), Positives = 173/487 (35%), Gaps = 35/487 (7%) Query: 26 IRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALS--RMSQQYGDVLQIRIGSTPV 83 + +++ P PG GW + H + + Q+YG + + ++G+ Sbjct: 1 MASTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLES 60 Query: 84 VVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNG--QSMSFSPDSGPVWAARRRLAQNG 141 V + + + +G + R D+ + + + W R Sbjct: 61 VYIIHPEDVAHLFKFEGS-YPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDR----VV 115 Query: 142 LKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAI 201 L + +A + + L +L +++ +G + + I + Sbjct: 116 LNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNV 175 Query: 202 CFGRRYDHNHQELL-SLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYS 260 FG R + + + ++ + P +P Y ++D + + Sbjct: 176 MFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELY-RLFRTKTWRDHVAAWDT 234 Query: 261 FMQKMVK-------EHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLD 313 K K + + E + I L++ ++ E + + + Sbjct: 235 IFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKS-----------EKMLLEDVKANITE 283 Query: 314 LFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFIL 373 + G +T + + W L + + VQ ++EE+ ++ +P ++A I Sbjct: 284 MLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIK 343 Query: 374 ETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFL 433 ET R + T+ D L+ + IP V V + + D + +P +F P R+L Sbjct: 344 ETLRLHP-ISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWL 402 Query: 434 TPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPI 493 + D + + + FG G R+C+G IA E+ LFL +L+ F V + D+ I Sbjct: 403 SKDKDLIHF---RNLGFGWGVRQCVGRRIAELEMTLFLIHILEN--FKVEMQHIGDVDTI 457 Query: 494 YGLTMKH 500 + L + Sbjct: 458 FNLILTP 464 >3EJB-B nrPDB Length = 404 Score = 181 bits (459), Expect = 6e-46, Method: Composition-based stats. Identities = 73/447 (16%), Positives = 154/447 (34%), Gaps = 79/447 (17%) Query: 54 TLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLY--- 110 KNP+ + + + + P ++G + A + + FK R L Sbjct: 10 EFLKNPYSFYDTLRAVH-PIYKGSFLKYPGWYVTGYE--ETAAILKDARFKVRTPLPESS 66 Query: 111 -TFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEV 169 + +S+ Q+ + P R LA T+ + ++ + Sbjct: 67 TKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP---------RTTESYQPYIIETVHH 117 Query: 170 LISTLQELMAGPGHFNP-YRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVV 228 L+ +Q + + + N+I +E L Sbjct: 118 LLDQVQGKKKMEVISDFAFPLASFVIANIIG-------VPEEDREQLKEWA--------A 162 Query: 229 GSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEH 288 DF + L ++ A + + ++ ++++++ + ++ D+ L++ Sbjct: 163 SLIQTIDFTRSRKALTEGNIMAVQAM-----AYFKELIQKRKRHPQQ----DMISMLLKG 213 Query: 289 CQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELD 348 ++ + L++E+ + + L AG +T IS S++ L+ +P K++E D Sbjct: 214 REKDK--------LTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPD 265 Query: 349 TVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVF 408 + + E R+ S T + D + G I +G V+ Sbjct: 266 ------------------LIGTAVEECLRYESPTQMT-ARVASEDIDICGVTIRQGEQVY 306 Query: 409 VNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVF 468 + N D ++ NP F R P + FG G C+G ++AR E Sbjct: 307 LLLGAANRDPSIFTNPDVFDITRSPNP-----------HLSFGHGHHVCLGSSLARLEAQ 355 Query: 469 LFLAILLQRVEFSVPLGVKVDMTPIYG 495 + + LLQR+ + P++G Sbjct: 356 IAINTLLQRMPSLNLADFEWRYRPLFG 382 >3S79-A nrPDB Length = 503 Score = 178 bits (451), Expect = 5e-45, Method: Composition-based stats. Identities = 81/471 (17%), Positives = 171/471 (36%), Gaps = 36/471 (7%) Query: 35 KGLKNPPGPWGWPLIGHMLTLGKNPHLALSR----MSQQYGDVLQIRIGSTPVVVLSGLD 90 +G + PGP IG +++ G+ + + ++ YG+ +++ I +++S Sbjct: 42 EGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSS 101 Query: 91 TIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASD 150 ++ + + I + ++ +W R L + Sbjct: 102 SMFHIM-KHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGL--- 157 Query: 151 PASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHN 210 + ++ + + L+E+ G+ + + + + + D + Sbjct: 158 ------VRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDES 211 Query: 211 HQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHY 270 +V + F D + +L + KDL + + + + Sbjct: 212 A----IVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRIS 267 Query: 271 KTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330 + D LI + L+ E + +L++ A DT++ ++ + L Sbjct: 268 TEEKLEECMDFATELILAEKRGD--------LTRENVNQCILEMLIAAPDTMSVSLFFML 319 Query: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390 + +P V+ I +E+ TVIG R ++ D L ME FI E+ R+ V + Sbjct: 320 FLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDLVM-RKA 377 Query: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIF 450 D + G+ + KG + +N +++ + + P+EF E F V F Sbjct: 378 LEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFA------KNVPYRYFQPF 430 Query: 451 GMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVD-MTPIYGLTMKH 500 G G R C G+ IA + L LL+R G V+ + I+ L++ Sbjct: 431 GFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHP 481 >2Z36-A nrPDB Length = 413 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 57/319 (17%), Positives = 112/319 (35%), Gaps = 52/319 (16%) Query: 205 RRYDHNHQELLSLVNLNNNFGEVVGSGN-PADFIPILRYLPNPSLNAFKDL-----NEKF 258 +R + +V+ +++ + P D + L LP PSL + L + F Sbjct: 117 KRLAALRPRIQDIVDHF--IDDMLATDQRPVDLVQAL-SLPVPSLVICELLGVPYTDHDF 173 Query: 259 YSFMQKMVKEHYKTFEK----GHIRDITDSLIEHCQEKQLDE---------NANVQLSDE 305 + M+ ++ +R D LI + + D+ L Sbjct: 174 FQSRTTMMVSRTSMEDRRRAFAELRAYIDDLITRKESEPGDDLFSRQIARQRQEGTLDHA 233 Query: 306 KIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHL 365 ++++ L AG +T IS ++ L+ +P ++ Sbjct: 234 GLVSLAFLLLTAGHETTANMISLGVVGLLSHPEQLTVVKANPGR---------------- 277 Query: 366 PYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPS 425 + E R+ + T D + G I G V V+ N D ++ +P+ Sbjct: 278 --TPMAVEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPA 335 Query: 426 EFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLG 485 ER + + FG G +C+G+ +AR E+ + L +R+ S+ L Sbjct: 336 VLDVER-----------GARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRIP-SLRLA 383 Query: 486 VKVDMTPIYGLTMKHACCE 504 V ++ P G ++ + E Sbjct: 384 VPMEDVPFKGDSVIYGVHE 402 >5OFQ-A nrPDB Length = 409 Score = 174 bits (442), Expect = 5e-44, Method: Composition-based stats. Identities = 70/347 (20%), Positives = 114/347 (32%), Gaps = 65/347 (18%) Query: 177 LMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADF 236 +M P H V + T G + LL V+ F V P Sbjct: 85 MMDPPKHTKLRNLVNKAFTPRAIQHLEG-HIEEIADYLLDEVSSKEKFDIVEDFAGPLPI 143 Query: 237 IPI--LRYLPNPSLNAFK------------DLNEKFYSFMQKM----------VKEHYKT 272 I I L +P FK + +E F MQK KE Sbjct: 144 IVIAELLGVPIQDRALFKKYSDDLVSGAENNSDEAFAKMMQKRNEGVIFLQGYFKEIIAE 203 Query: 273 FEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMY 332 ++ D+ L+E E L++E+++ + L AG +T T I+ + Y Sbjct: 204 RQQNKQEDLISLLLEA-------EIDGEHLTEEEVLGFCILLLVAGNETTTNLITNGVRY 256 Query: 333 LVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR 392 + + VQ +++ ++ V + ET R+ + I Sbjct: 257 MTEDVDVQNEVRRDISLV------------------PNLVEETLRYYPPIQ-AIGRIAAE 297 Query: 393 DTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGM 452 D L I +G+ V N D + P F+ R P + FG Sbjct: 298 DVELGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHRKTNP-----------HVSFGF 346 Query: 453 GKRKCIGETIARWEVFLFLAILLQRVEFSVPLGV---KVDMTPIYGL 496 G C+G +AR E + LL++ FS +D ++G+ Sbjct: 347 GIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPIDSPFVFGV 393 >5Y1I-A nrPDB Length = 403 Score = 174 bits (440), Expect = 9e-44, Method: Composition-based stats. Identities = 78/436 (17%), Positives = 134/436 (30%), Gaps = 80/436 (18%) Query: 75 QIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQ----SMSFSPDSGPV 130 +I GSTP VV D R L G D Y SF+ P Sbjct: 37 RIWDGSTPWVVTRHADQ-RALLSDPRVSHDGLRDGYPHISADFKFLSMAQPSFAGQDDPE 95 Query: 131 WAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYV 190 RR+ + I + + K + LI + +AGP + + Sbjct: 96 HGRIRRMVTLPFTARRI---------EAMRPAIQKITDELIDGM---LAGPKPVDLVEAL 143 Query: 191 VV-SVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLN 249 + VIC + + +E L N + + I YL Sbjct: 144 ALPVPVRVICEML---GVPYEDREFLQQNNNAMIYRDTAQGDAQKAAIAQAMYLKELVGT 200 Query: 250 AFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIIN 309 D + DI L + +++ + Sbjct: 201 KLGDRGD-----------------------DILSDLAVQVEAG--------EITQDDAAG 229 Query: 310 IVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYME 369 I + L GAG +T I+ + L+ NP ++++ D + + Sbjct: 230 IGMMLLGAGHETTANMIALGTLALLENPEQLAEVRDSDDPKV----------------IV 273 Query: 370 AFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN-PSEFL 428 + E R+ + T+ D + G I G + N D L+ P Sbjct: 274 NTVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLD 333 Query: 429 PERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKV 488 R + + + FG G +C+G T+AR E+ + + LL+R+ ++ L + Sbjct: 334 IHR----------ANARRHLAFGYGVHQCLGATLARVELQIVYSTLLRRIP-TLALAGTL 382 Query: 489 DMTPIYGLTMKHACCE 504 D P + H E Sbjct: 383 DEIPFKHDQIAHGVYE 398 >5L94-A nrPDB Length = 410 Score = 171 bits (433), Expect = 7e-43, Method: Composition-based stats. Identities = 68/408 (16%), Positives = 139/408 (34%), Gaps = 69/408 (16%) Query: 86 LSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSF 145 + D +++ L ++ R + G S+ P A R L Sbjct: 49 VFHYDGVKEVLEQKNIFSSDRRPPQNQRQTALGTSLI--NIDPPKHAEMRALVNKAFTP- 105 Query: 146 SIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGR 205 ++ K A + LQE+ + ++ + ++ A G Sbjct: 106 -----------KAMKAWEPKIARITNELLQEVEHLE-DIDIVEHLSYPLPVMVIADILGV 153 Query: 206 RYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKM 265 + Q ++ +++ +G + L L + N++ ++ ++ Sbjct: 154 PIEDQRQ--------FKDWSDIIVAGPSNNERETLEKLQQEKMK----ANDELETYFYRI 201 Query: 266 VKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTA 325 ++E DI L++ +E + QL+DE+I+ + L AG +T T Sbjct: 202 IEEKRTRP----GDDIISVLLQAKEEGK-------QLTDEEIVGFSILLLIAGNETTTNL 250 Query: 326 ISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFT 385 IS ++ L+ + +++ E + + + I E R+ S V Sbjct: 251 ISNTIYCLMEDKASFERLKREKE------------------LLPSGIEEVLRYRSPVQ-A 291 Query: 386 IPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSE 445 + D +L G + G V + D + + +P F +R Sbjct: 292 LHRIVKEDVTLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDRKPNV---------- 341 Query: 446 KVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPI 493 + FG G C+G +AR E + LA L+ R + ++ PI Sbjct: 342 -HMAFGRGIHFCLGAPLARIEAKIMLAELIDRYP-QMDWSPSFELKPI 387 >5VWS-A nrPDB Length = 393 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 84/435 (19%), Positives = 147/435 (33%), Gaps = 77/435 (17%) Query: 72 DVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVW 131 V + + G + + D +RQ L R L T G+ D P Sbjct: 32 PVWRDQFG---IYHVFRYDDVRQILGDYQTFSSDRTRLMP-TAQGFGKGGITMIDP-PEH 86 Query: 132 AARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVV 191 +RRL + SI +E + + A+ L+ L Y V Sbjct: 87 RHQRRLITHAFTPQSI---------SAMEPRIRQIADHLLDELPGPEFDLVEHFAYPLPV 137 Query: 192 VSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAF 251 + + ++ + G R +L + + + S ++ P + Sbjct: 138 IVIAELL-GVPPGDR------------HLFRTWSDRLMSLQVENYAD-----PELARTV- 178 Query: 252 KDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIV 311 + M ++EH ++ D+ L++ E + +L E+++N Sbjct: 179 ----AAAMTEMNDYLREHCRSRRTHPRDDLLTRLVQAEVEGK-------RLDLEEVVNTA 227 Query: 312 LDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAF 371 L AG T T I +++ L +P ++ ++ +D S +P A Sbjct: 228 SLLLLAGHLTTTVLIGNTMLCLWDHPEAEKAVR---------------ADPSLIP---AA 269 Query: 372 ILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPER 431 + E+ R S TTRD ++ G IP R V NHD + + +P F R Sbjct: 270 LEESLRLRSPF-LQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFDLHR 328 Query: 432 FLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPL---GVKV 488 + I FG G C+G + R E + L LL R P G+ Sbjct: 329 -----------QTTGHIAFGHGVHFCLGAQLGRLEGRIALERLLGRFTEIHPWPREGISF 377 Query: 489 DMTPIYGLTMKHACC 503 + I+G + C Sbjct: 378 YQSAIFGASRMPVRC 392 >2ZBZ-A nrPDB Length = 412 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 63/305 (20%), Positives = 118/305 (38%), Gaps = 53/305 (17%) Query: 205 RRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKF--YSFM 262 +R E+ +V+ E++ +G AD + LP PS+ + L + + F Sbjct: 117 KRIKGMRPEVEEVVHGF--LDEMLAAGPTADLVSQF-ALPVPSMVICRLLGVPYADHEFF 173 Query: 263 QKMVKEHYKTFE-------KGHIRDITDSLIEHCQEKQ---------LDENANVQLSDEK 306 Q K ++ + + + D LI Q + D+ AN ++ E+ Sbjct: 174 QDASKRLVQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGALVADQLANGEIDREE 233 Query: 307 IINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLP 366 +I+ + L AG +T + S S++ L+ +P ++ +DRS +P Sbjct: 234 LISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALR---------------ADRSLVP 278 Query: 367 YMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSE 426 + E R+ + T D ++G I G V V N D ++ +P Sbjct: 279 ---GAVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTVYEDPDA 335 Query: 427 FLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR---VEFSVP 483 R + + FG G +C+G+ +AR E+ + L L+ R + +VP Sbjct: 336 LDIHR-----------SARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRLAVP 384 Query: 484 LGVKV 488 + V Sbjct: 385 VEQLV 389 >4JBT-A nrPDB Length = 410 Score = 169 bits (428), Expect = 3e-42, Method: Composition-based stats. Identities = 79/434 (18%), Positives = 138/434 (31%), Gaps = 84/434 (19%) Query: 71 GDVLQIRIGSTPVVVLSGLDTIRQALVRQ-----------GDDFKGRPDLYTFTLISNGQ 119 G + +I + P + ++G RQ L +I + Sbjct: 30 GPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDINAWSLWQSGTVTRQWPLIGMIDVDR 89 Query: 120 SMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMA 179 SM GP R L + + L+ + + L+ L+ A Sbjct: 90 SM--FTVDGPEHRRLRIKTTQALTRRRLDA---------LKPTIERYVAELLDDLERAGA 138 Query: 180 GPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPI 239 + + + + G + Q L+ F ++ Sbjct: 139 DGAVVDLKSVFAYPLPMRVISALMGVPSEDQEQ----LLTWYKAFFSILT---------- 184 Query: 240 LRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENAN 299 P + ++E + + +MV KT E G D+T +LI + Sbjct: 185 ------PQDERLRVIDE-MHGYFTEMV--RRKTAEPGD--DLTSALIYA-------TDGE 226 Query: 300 VQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRL 359 L++E++I + L AG +T + I ++ L+ +P R ++ D IG Sbjct: 227 TPLTEEEVIGNLQALVAAGHETTVSLILTAVRALLSHPEQLRLVR---DGEIG------- 276 Query: 360 SDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 419 E I ET R V + T D L IP+G V ++ I D Sbjct: 277 --------WETAIEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDIT 328 Query: 420 LW-VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 + + +F R + + I FG G C G +AR E + L L R Sbjct: 329 VHGADADDFDITR----------ATAARHISFGHGPHICPGAALARLEAAIALPALFTRF 378 Query: 479 EFSVPLGVKVDMTP 492 + + +D P Sbjct: 379 P-HLHPALPLDQIP 391 >4RM4-A nrPDB Length = 396 Score = 168 bits (425), Expect = 6e-42, Method: Composition-based stats. Identities = 68/310 (21%), Positives = 105/310 (33%), Gaps = 51/310 (16%) Query: 206 RYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPI--LRYLPNPSLNAFKDLNEKFYSFMQ 263 R EL+ + F V P I I L +P+ + FK ++ S + Sbjct: 111 RIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKAWSDLLVSTPK 170 Query: 264 KMVKEHYKTF--EKGHIRDITDSLIEHCQEKQL-------------DENANVQLSDEKII 308 +E K F E+ + + E++ E +LS E++I Sbjct: 171 DKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAEETGEKLSGEELI 230 Query: 309 NIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYM 368 L AG +T T IS ++ ++ P V ++ RSH M Sbjct: 231 PFCTLLLVAGNETTTNLISNAMYSILETPGVYEEL------------------RSHPELM 272 Query: 369 EAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFL 428 + E R + P + RDT + G I +G V N D+ + P F Sbjct: 273 PQAVEEALRFRAPAP-VLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFD 331 Query: 429 PERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKV 488 R P I FG G C+G +AR E + L L+ P V Sbjct: 332 IRRHPNP-----------HIAFGHGIHFCLGAPLARLEANIALTSLISAF----PHMECV 376 Query: 489 DMTPIYGLTM 498 +TPI + Sbjct: 377 SITPIENSVI 386 >4UBS-A nrPDB Length = 393 Score = 166 bits (419), Expect = 3e-41, Method: Composition-based stats. Identities = 71/425 (16%), Positives = 128/425 (30%), Gaps = 81/425 (19%) Query: 80 STPVVVLSGLDTIRQALVRQ----GDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARR 135 V V++G R L Q P + ++ P +R Sbjct: 36 GRSVWVVTGHAAARALLSDQRLSSDRTLPRFPATTERFEAVRTRRVALLGVDDPEHRTQR 95 Query: 136 RLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVT 195 R+ + L + + + L+ + E P + + Sbjct: 96 RMLVPSFT---------LKRAAALRPRIQETVDGLLDAM-EAQGPPAELVSAFALP-LPS 144 Query: 196 NVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLN 255 VICA+ DH+ E S R L P + +D Sbjct: 145 MVICALLGVPYADHDFFESQSR-----------------------RLLRGPGIAEVQDAR 181 Query: 256 EKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLF 315 + ++ ++ K G + D LI+ + + +++++ L Sbjct: 182 AQLDDYLYALIDRKRKEPGDG----LLDDLIQEQLNRGT-------VDRAELVSLATLLL 230 Query: 316 GAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILET 375 AG +T IS L+ +P +++ E M A + E Sbjct: 231 IAGHETTANMISLGTFTLLRHPEQLAELRAEPG------------------LMPAAVEEL 272 Query: 376 FRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTP 435 R S + + T D + G I V IN D + P R Sbjct: 273 LRFLS-IADGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHR---- 327 Query: 436 DGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPI-Y 494 + + FG G +C+G+ +AR E+ + L L +R+ + L D P Sbjct: 328 -------SARHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLP-GLRLAAPADEIPFKP 379 Query: 495 GLTMK 499 G T++ Sbjct: 380 GDTIQ 384 >5LIE-A nrPDB Length = 414 Score = 164 bits (415), Expect = 8e-41, Method: Composition-based stats. Identities = 73/393 (18%), Positives = 131/393 (33%), Gaps = 71/393 (18%) Query: 120 SMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMA 179 + P RRL +GL +E+ + + A L+ ++ Sbjct: 92 GQVLNMMDDPRHTRIRRLVSSGLTP---------RMIRRVEDDLRRRARGLLDGVE---- 138 Query: 180 GPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPI 239 PG + + + + + + L V +F G+ +P Sbjct: 139 -PGAPFDFVVEIAAELPMQMICILLGVPETDRHWLFEAVEPGFDF-----RGSRRATMPR 192 Query: 240 LRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENAN 299 L +D + Y++ +++ G + D ++ +D+ Sbjct: 193 LNV---------EDAGSRLYTYALELI--------AGKRAEPADDMLSVVANATIDDPDA 235 Query: 300 VQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRL 359 LSD ++ LF AG +T +I+ L+ L NP + + Sbjct: 236 PALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTL---------------- 279 Query: 360 SDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 419 RS + I E R +S P + + +R SL G I G+ V V + N D Sbjct: 280 --RSDFELLPTAIEEIVRWTSPSP-SKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPS 336 Query: 420 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 ++ EF R P + FG G C+G +AR E+ + LL R Sbjct: 337 VFDRADEFDITRKPNP-----------HLGFGQGVHYCLGANLARLELRVLFEELLSRFG 385 Query: 480 FSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS 512 V+V + + +H H ++LR Sbjct: 386 -----SVRVVEPAEWTRSNRHTGIRHLVVELRG 413 >4GGV-A nrPDB Length = 418 Score = 164 bits (414), Expect = 1e-40, Method: Composition-based stats. Identities = 69/394 (17%), Positives = 124/394 (31%), Gaps = 62/394 (15%) Query: 86 LSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSF 145 + G L L ++ + S P R+L Sbjct: 58 VYGYPEAMDILNDHDTFTSDLAHLLPVSVDAPLLEGDMSQMDPPRHRKYRQLVSRAFTP- 116 Query: 146 SIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGR 205 +E V+ L+ + + + V V + + G Sbjct: 117 --------RLVADMETRVADITRELLDAVDGKPEIEIAADLAYPLPVIVIAELLGVPAGD 168 Query: 206 RYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKM 265 R D + ++ + F + SG + +D E+ + M Sbjct: 169 R-DLFKKWADDIIEGFSGFSFLDTSGQGEQDV--------------RDATERLRPLLDYM 213 Query: 266 VKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTA 325 + R + L+ H + ++D +L+D +I+N+ L G T T Sbjct: 214 AGHVTE-----RRRTPREDLLTHLVQAEVD---GERLTDNEIVNVANILLVTGHITTTMT 265 Query: 326 ISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFT 385 + +++ L +P V K++ +DRS +P I E R S Sbjct: 266 LGNTVLCLDADPEVAAKVR---------------ADRSLVP---GAIEEALRVLSPSA-A 306 Query: 386 IPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSE 445 + T+R+ + G IPK + V + N D + + +P + P R P Sbjct: 307 LARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDPTRDPNP---------- 356 Query: 446 KVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 FG G C+G +AR E + L L R Sbjct: 357 -HFGFGRGIHFCLGAPLARLEGRVALNALFDRFP 389 >4ZGX-A nrPDB Length = 489 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 68/410 (16%), Positives = 142/410 (34%), Gaps = 22/410 (5%) Query: 57 KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLIS 116 ++ HL + + Q+ G + + +G +V + + + + L + R L + Sbjct: 39 EHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDV-EKLQQVDSLHPCRMILEPWVAYR 97 Query: 117 NGQS--MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTL 174 + +GP W R L ++ ++ ++ L + Sbjct: 98 QHRGHKCGVFLLNGPEWRFNRL----RLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKV 153 Query: 175 QELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDH-NHQELLSLVNLNNNFGEVVGSGNP 233 + G + + FG R H + +N + + S Sbjct: 154 LQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQ 213 Query: 234 ADFIP--ILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQE 291 F+P + R++ + + + + +++ Y+ + T + E + Sbjct: 214 LMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLK 273 Query: 292 KQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVI 351 +LS E I ++L DT + +L L NP VQ+ +++E Sbjct: 274 A--------ELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAA 325 Query: 352 GRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQ 411 + LP + A + ET R V + + D L+ ++IP G V V Sbjct: 326 ASISEHPQKATTELPLLRAALKETLRLYP-VGLFLERVVSSDLVLQNYHIPAGTLVQVFL 384 Query: 412 WQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGET 461 + + + L+ P + P+R+L G+ + FG G R+C+G Sbjct: 385 YSLGRNAALFPRPERYNPQRWLDIRGSGRNF---HHVPFGFGMRQCLGRR 431 >2Y5N-A nrPDB Length = 417 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 52/282 (18%), Positives = 110/282 (39%), Gaps = 55/282 (19%) Query: 221 NNNFGEVVGSGNPADFIPI------------LRYLPNPSLNAFKDLNEKFYSFMQKMVKE 268 + ++ +G PAD + + L +P+ + F + F S + +E Sbjct: 139 HELVDQMAATGQPADLVAMFARQLPVRVICELLGVPSADHDRFTRWSGAFLSTAEVTAEE 198 Query: 269 HYKTFEKGH----------IRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAG 318 + E+ + ++ TD L+ + + +++ LS+++++++ + L AG Sbjct: 199 MQEAAEQAYAYMGDLIDRRRKEPTDDLVSALVQARDQQDS---LSEQELLDLAIGLLVAG 255 Query: 319 FDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRH 378 +++ TT I+ + L+ P ++R++ + + + E R Sbjct: 256 YESTTTQIADFVYLLMTRPELRRQL------------------LDRPELIPSAVEELTRW 297 Query: 379 SSF-VPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG 437 V P D +L+G I G V + N DQ + + +R Sbjct: 298 VPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDR------ 351 Query: 438 AIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 + + FG G C+G +AR E+ + L +LLQR+ Sbjct: 352 -----TPNQHLGFGHGVHHCLGAPLARVELQVALEVLLQRLP 388 >6M7X-A nrPDB Length = 484 Score = 163 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 72/414 (17%), Positives = 148/414 (35%), Gaps = 30/414 (7%) Query: 57 KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLIS 116 ++ HL + + Q+ G + + +G +V + + + + L + R L + Sbjct: 39 EDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYR 97 Query: 117 NGQS--MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTL 174 + +GP W R L ++ + ++ ++ L + Sbjct: 98 QHRGHKCGVFLLNGPEWRFNRL----RLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKV 153 Query: 175 QELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDH-NHQELLSLVNLNNNFGEVVGSGNP 233 + G + + FG R H + +N + + S Sbjct: 154 LQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQ 213 Query: 234 ADFIPI-LRYLPNPSL--NAFKDLNEKFY---SFMQKMVKEHYKTFEKGHIRDITDSLIE 287 F+P L +P + F+ + F + +QK+ +E + + + + + L+ Sbjct: 214 LMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLL- 272 Query: 288 HCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEEL 347 N +LS + I ++L DT + +L L NP VQ+ +++E Sbjct: 273 -----------NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQES 321 Query: 348 DTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCV 407 + LP + A + ET R V + + D L+ ++IP G V Sbjct: 322 LAAAASISEHPQKATTELPLLRAALKETLRLYP-VGLFLERVASSDLVLQNYHIPAGTLV 380 Query: 408 FVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGET 461 V + + + L+ P + P+R+L G+ + FG G R+C+G Sbjct: 381 RVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNF---YHVPFGFGMRQCLGRR 431 >3NC3-A nrPDB Length = 441 Score = 163 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 82/428 (19%), Positives = 147/428 (34%), Gaps = 68/428 (15%) Query: 54 TLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFT 113 NP+ S++ ++ V S +S +R L + D F + + Sbjct: 50 QFQNNPYAYFSQLREE-DPVH--YEESIDSYFISRYHDVRYIL-QHPDIFTTKSLVERAE 105 Query: 114 LISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLIST 173 + G + G +A+RR+ +L + + AE L++ Sbjct: 106 PVMRGP--VLAQMHGKEHSAKRRIVVRSF---------IGDALDHLSPLIKQNAENLLAP 154 Query: 174 LQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNP 233 E G +V + + +R E S V Sbjct: 155 YLER--GKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSGV--------------- 197 Query: 234 ADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQ 293 ADFI + P ++ +E+ ++ ++KE D+ L Sbjct: 198 ADFITSISQSPEARAHSLW-CSEQLSQYLMPVIKERRVNP----GSDLISILCTS----- 247 Query: 294 LDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGR 353 E + LSD+ I+ ++L++ A + ++ + +L+ NP + Sbjct: 248 --EYEGMALSDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDV---------- 295 Query: 354 SRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQ 413 L+DRS +P I ET R+ V IP ++DT + G I K VF Sbjct: 296 -----LADRSLVP---RAIAETLRYKPPVQL-IPRQLSQDTVVGGMEIKKDTIVFCMIGA 346 Query: 414 INHDQKLWVNPSEFLPERFLTPDGAIDKVLSE--KVIIFGMGKRKCIGETIARWEVFLFL 471 N D + + P F R D I S + + FG G C+G A+ E+ + Sbjct: 347 ANRDPEAFEQPDVFNIHR---EDLGIKSAFSGAARHLAFGSGIHNCVGTAFAKNEIEIVA 403 Query: 472 AILLQRVE 479 I+L ++ Sbjct: 404 NIVLDKMR 411 >6A7J-A nrPDB Length = 411 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 78/442 (17%), Positives = 140/442 (31%), Gaps = 96/442 (21%) Query: 71 GDVLQIRI-GSTPVVVLSGLDTIRQALVR--------------QGDDFKGRPDLYTFTLI 115 G + ++ + G V ++ R L +G+ D L+ Sbjct: 26 GPLAEVELPGGVHVYAVTHHKEARALLTDSRVVKDINVWNAWQRGEIPA---DWPLIGLV 82 Query: 116 SNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQ 175 + G+SM GP R L L + A + + L Sbjct: 83 NPGRSM--LTVDGPDHRRLRTLVAQALTVKRVEKLRAG---------IEALTNASLERLA 131 Query: 176 ELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPAD 235 L AG + NVI + D L F + + P + Sbjct: 132 ALPAGEPVDLKAEFAYPLPMNVISELM---GVDAADHPRLK-----ELFEKFFSTQTPPE 183 Query: 236 FIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLD 295 +P + + K+V+E D+T +LI + Sbjct: 184 EVP--------------QMMADLGTLFTKIVEEKKANP----GDDLTSALIAASE----- 220 Query: 296 ENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSR 355 L+DE+I+N + + AG +T + I + L ++P ++K+ Sbjct: 221 --DGDHLTDEEILNTLQLIIAAGHETTISLIVNVVEALAIHPEQRKKVLS---------- 268 Query: 356 RPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIN 415 +P E I ET R ++ + T D + +PKG + V+ + Sbjct: 269 -------GEIP-WEGVIEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALG 320 Query: 416 HDQKLW-VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAIL 474 D++ + +F R + I FG G C G ++R E + L L Sbjct: 321 RDEEQYGPTAGDFDATR-----------TPNRHIAFGHGPHVCPGAALSRLEAGIALPAL 369 Query: 475 LQRV---EFSVPLGVKVDMTPI 493 +R + +VP ++ PI Sbjct: 370 YERFPELDLAVP-AAELRNKPI 390 >5YSW-A nrPDB Length = 441 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 83/444 (18%), Positives = 143/444 (32%), Gaps = 86/444 (19%) Query: 71 GDVLQIRIG-STPVVVLSGLDTIRQALVR---QGDDFKGRPDLYTFTLISN-------GQ 119 G V + + P ++SG + R L D F+ P + + Sbjct: 64 GPVARATLAAGDPFWLVSGYEEARAVLSDPRFSSDRFQYHPWFKELSPEFRERLRDDKAR 123 Query: 120 SMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMA 179 + SF P R+L I A + + + + L Sbjct: 124 AGSFINMDPPEHTRYRKLLTGQFTVRRIRELGA---------RIDEIVAGRVDAM--LAG 172 Query: 180 GPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPI 239 G + + + +IC + G RY+ + L Sbjct: 173 GTTADLMTEFAFPAPSLMICELL-GVRYEDRAEFQQRASALLQMNA-------------- 217 Query: 240 LRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENAN 299 P A K+ + +FMQ +V + DI LI H A+ Sbjct: 218 ------PVAEAVKNADA-LRAFMQALVTDKRANP----AGDIISGLIHHA-------GAD 259 Query: 300 VQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRL 359 L+D+++INI L AG+DT + + + L+ P ++++ + Sbjct: 260 PALTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDDPSRIAD------- 312 Query: 360 SDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 419 + E R+ S V I D G +IP G V V+ N D + Sbjct: 313 -----------AVEELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDAR 361 Query: 420 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 W +P R + FG G +C+G+ +AR E+ A LL+R+ Sbjct: 362 HWPDPD-LDLTR-----------PRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLP 409 Query: 480 FSVPLGVKVDMTPIYGLTMKHACC 503 +V L V + P+ + + Sbjct: 410 -NVRLAVPPEEVPLRNDMLTYGVH 432 >3ABB-A nrPDB Length = 408 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 81/419 (19%), Positives = 145/419 (34%), Gaps = 80/419 (19%) Query: 80 STPVVVLSGLDTIRQALVR-QGDDFKGRPDLYTFTLISNGQSMSFSPDSG---PVWAARR 135 P +++G R LV + G PD + + P G PV A +R Sbjct: 47 GRPAWLITGHAEGRALLVDPRLSSDWGHPDFPVVVRRTEDRGGLAFPLIGVDDPVHARQR 106 Query: 136 RLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVT 195 R+ ++ L+ V + + +++ GPG + + + Sbjct: 107 RMLIPSF-----GVKRMNAIRPRLQSLVDRLLDDMLAK------GPGADLVSAFALPVPS 155 Query: 196 NVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLN 255 IC ELL + +++F E +F+ + Sbjct: 156 VAIC-------------ELLGVPYGDHDFFEECSR----NFVG------AATSAEADAAF 192 Query: 256 EKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLF 315 + Y+++ +V E D L++ +QL+E L ++++ I L L Sbjct: 193 GELYTYLHGLVGRKQAEPE--------DGLLDELIARQLEEG---DLDHDEVVMIALVLL 241 Query: 316 GAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILET 375 AG +T AI+ + L+ +P + + V G + E Sbjct: 242 VAGHETTVNAIALGALTLIQHPEQIDVLLRDPGAVSG------------------VVEEL 283 Query: 376 FRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTP 435 R +S + D + G I G V V+ +N D K + NP F R Sbjct: 284 LRFTSVSDHIV-RMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFDARR---- 338 Query: 436 DGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIY 494 + + FG G +C+G+ +AR E+ + L L R+ + L V +D PI Sbjct: 339 -------NARHHVGFGHGIHQCLGQNLARAELEIALGGLFARIP-GLRLAVPLDEVPIK 389 >2VZM-A nrPDB Length = 436 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 49/278 (17%), Positives = 93/278 (33%), Gaps = 44/278 (15%) Query: 223 NFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDIT 282 + E + P I L +P P AF+ + F + G++ + Sbjct: 163 DLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLI 222 Query: 283 D--------SLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 334 D L+ + + +L+ E+++ + L AG +T I+ + L+ Sbjct: 223 DSKRGQDGEDLLSALV--RTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALL 280 Query: 335 MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDT 394 +P + R+ + ++ + E R+ V Sbjct: 281 SHPDQLAAL------------------RADMTLLDGAVEEMLRYEGPVESATYRFPVEPV 322 Query: 395 SLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGK 454 L G IP G V V + + + +P F R + + FG G Sbjct: 323 DLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRR-----------DTAGHLAFGHGI 371 Query: 455 RKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTP 492 CIG +AR E + + LL+R + +D++P Sbjct: 372 HFCIGAPLARLEARIAVRALLERC-----PDLALDVSP 404 >5IT1-A nrPDB Length = 399 Score = 158 bits (399), Expect = 6e-39, Method: Composition-based stats. Identities = 56/340 (16%), Positives = 100/340 (29%), Gaps = 46/340 (13%) Query: 177 LMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGS---GNP 233 P H + + + T E L + ++V + P Sbjct: 89 WQDAPEHTDDRKLLAKEFTVRRMQAL-RPNIQRIVDEHLDAIEARGGPVDLVKTFANPVP 147 Query: 234 ADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFE---------KGHIRDITDS 284 + I L +P F+++ E Q + + D Sbjct: 148 SMVISDLFGVPAERRAEFQEIAEAMMRVDQDAAATEAAGMRLGGLLYQLVQERRANPGDD 207 Query: 285 LIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQ 344 LI E+ + + D ++N L A DT I L+ P +Q Sbjct: 208 LISALI---TTEDPDGVIDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDRPDQLALLQ 264 Query: 345 EELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKG 404 ++ + + E R+ + F T+D + G I KG Sbjct: 265 KDPS------------------LIGNAVEELLRYLTIGQFGAERVATQDGEIGGVRIAKG 306 Query: 405 RCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIAR 464 V + + D +P F R P + FG G +CIG+ +AR Sbjct: 307 EQVVTHLLSADFDPAFVEDPERFDITRRPAP-----------HLAFGFGAHQCIGQQLAR 355 Query: 465 WEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCE 504 E+ + L +R ++ L V+ + + E Sbjct: 356 IELQIVFGTLFRRFP-TLRLAKPVEELRFRNDMVFYGVHE 394 >5XW2-A nrPDB Length = 419 Score = 158 bits (399), Expect = 6e-39, Method: Composition-based stats. Identities = 69/305 (22%), Positives = 111/305 (36%), Gaps = 53/305 (17%) Query: 206 RYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAF---KDLNEKFYSF- 261 R QELL V + F + P + L PS + + E +S Sbjct: 124 RITALTQELLDAVADRDTFDLMTALAYPLPVTVVAELLSIPSADRHLFEGWMTEIVHSLG 183 Query: 262 ---MQKMVKEHYKTFEKGH--IRDITDSLIEHCQEKQLDENAN------------VQLSD 304 M+ ++ + FE G +R + + L EH E + + +L+D Sbjct: 184 DVSMEDAPEDQERIFEAGMAPMRKMLEYLREHAAECRRRPRGDLMGKLIEAEVDGRRLTD 243 Query: 305 EKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSH 364 I+N L AG+ T T I +++ L P +++ +DRS Sbjct: 244 NHIVNFAKMLLIAGYLTTTMLIGNTVLCLDSYPEQAARVR---------------ADRSL 288 Query: 365 LPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNP 424 +P + + E+ R S V T +TTRD + G + + V V N D + + P Sbjct: 289 IPGL---LEESMRFLSPVAATY-RATTRDVEVAGQRLSADQMVMVWFGAANRDARQFAEP 344 Query: 425 SEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE--FSV 482 F R P + FG G C+G +AR E + L LL R ++ Sbjct: 345 ELFDMTRGPNP-----------HLGFGRGIHFCLGGPLARMEGRVALDHLLDRFPELYTD 393 Query: 483 PLGVK 487 P Sbjct: 394 PERPP 398 >4OQR-A nrPDB Length = 457 Score = 158 bits (399), Expect = 6e-39, Method: Composition-based stats. Identities = 78/455 (17%), Positives = 140/455 (30%), Gaps = 102/455 (22%) Query: 43 PWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRI-GSTPVVVLSGLDTIRQALVRQGD 101 P P G + +P L + V +R +++ R ++ Sbjct: 50 PVTLP-TGRAVGYPFDPPPDLV----KLPPVSPMRFPDGHIGWLVTSHAAARTVMID--P 102 Query: 102 DFKGRPDLY-TFTLISNGQSMS--------FSPDSGPVWAARRRLAQNGLKSFSIASDPA 152 F RP+ + + F+ P RR+ + I Sbjct: 103 RFSNRPEHKHPVFSVIPRPGGATKAPAPGWFTNMDAPEHTRYRRMLISQFTVRRIKE--- 159 Query: 153 SSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQ 212 LE + + E + + + AGP + + + VIC + DH Sbjct: 160 ------LEPRIVRITEDHLDAMAK--AGPPVDLVQAFALPVPSLVICELLGVSYADHAFF 211 Query: 213 ELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKT 272 + + + +V D + K ++ ++V + Sbjct: 212 QEQTTI--------MVSVDKTQDEVT--------------TALGKLTRYIAELVATKRLS 249 Query: 273 FEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMY 332 + D+ SLI + L+DE++ NI L L AG +T + Sbjct: 250 PKD----DLLGSLIT-----------DTDLTDEELTNIALILLVAGHETTANMLGLGTFA 294 Query: 333 LVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIP-HSTT 391 L+ +P + + E R+ S V P + Sbjct: 295 LLQHPEQIANLDS-----------------------PDAVEELLRYLSIVHLGTPNRAAL 331 Query: 392 RDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFG 451 D L+G I KG V + +N D K++ P +R V + K FG Sbjct: 332 EDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR----------VDARKHAAFG 381 Query: 452 MGKRKCIGETIARWEVFLFLAILLQRV---EFSVP 483 G +C+G+ +AR E+ + L R +VP Sbjct: 382 GGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVP 416 >4OQS-A nrPDB Length = 433 Score = 158 bits (399), Expect = 6e-39, Method: Composition-based stats. Identities = 77/455 (16%), Positives = 138/455 (30%), Gaps = 102/455 (22%) Query: 43 PWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRI-GSTPVVVLSGLDTIRQALVRQGD 101 P P G + +P L + V +R +++ R ++ Sbjct: 11 PVTLP-TGRAVGYPFDPPPDLV----KLPPVSPMRFPDGHIGWLVTSHAAARTVMID--P 63 Query: 102 DFKGRPDLY-TFTLISNGQSMS--------FSPDSGPVWAARRRLAQNGLKSFSIASDPA 152 F RP+ + + F P RR+ + I Sbjct: 64 RFSNRPEHKHPVFSVIPRPGGATKAPAPGWFINMDAPEHTRYRRMLISQFTVRRIKE--- 120 Query: 153 SSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQ 212 LE + + E + + + AGP + + + VIC + DH Sbjct: 121 ------LEPRIVQITEDHLDAMAK--AGPPVDLVQAFALPVPSLVICELLGVSYADHAFF 172 Query: 213 ELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKT 272 + + + + D + K ++ ++V + Sbjct: 173 QEQTTI--------MASVDKTQDEVT--------------TALGKLTRYIAELVATKRLS 210 Query: 273 FEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMY 332 + D+ SLI + L+DE++ NI L L AG +T + Sbjct: 211 PKD----DLLGSLIT-----------DTDLTDEELTNIALLLLVAGHETTANMLGLGTFA 255 Query: 333 LVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIP-HSTT 391 L+ +P + + E R+ S V P + Sbjct: 256 LLQHPEQIAALDS-----------------------PDAVEELLRYLSIVHLGTPNRAAL 292 Query: 392 RDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFG 451 D L+G I KG V + +N D K++ P +R V + K FG Sbjct: 293 EDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR----------VDARKHAAFG 342 Query: 452 MGKRKCIGETIARWEVFLFLAILLQRV---EFSVP 483 G +C+G+ +AR E+ + L R +VP Sbjct: 343 GGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVP 377 >5CJE-A nrPDB Length = 393 Score = 158 bits (398), Expect = 8e-39, Method: Composition-based stats. Identities = 50/311 (16%), Positives = 95/311 (30%), Gaps = 45/311 (14%) Query: 206 RYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNA--FKDLNEKF----- 258 R LL + V P I L P ++ F+ L+ + Sbjct: 113 RIQEITDGLLDEMLPRGRADLVDSFAYPLPITVICELLGVPDIDRVTFRALSNEIVAPTG 172 Query: 259 ----YSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDL 314 + +++ + + D L+ + ++ + +LS E++ + L Sbjct: 173 GDAELAAYERLAAYLDELIDDKRSTAPADDLLGDLIRTRAED--DDRLSGEELRAMAFIL 230 Query: 315 FGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILE 374 AG +T I+ + L+ +P + R+ + ++ + E Sbjct: 231 LVAGHETTVNLITNGVHTLLTHPDQLAAL------------------RADMTLLDGAVEE 272 Query: 375 TFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 434 R V + G I +G V + D +P F R Sbjct: 273 VLRFEGPVETATYRYAAESMEIGGTAIAEGDPVMIGLDAAGRDPARHPDPHVFDIHR--- 329 Query: 435 PDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR---VEFSVPLGVKVDMT 491 + + FG G C+G +AR E + L LL+R + P G + Sbjct: 330 --------APQGHLAFGHGIHYCLGAPLARLEARVALRSLLERCPDLALDGPPGARPPGM 381 Query: 492 PIYGLTMKHAC 502 I G+ Sbjct: 382 LIRGVRRLPVR 392 >1EHE-A nrPDB Length = 403 Score = 158 bits (398), Expect = 8e-39, Method: Composition-based stats. Identities = 58/374 (15%), Positives = 122/374 (32%), Gaps = 72/374 (19%) Query: 123 FSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPG 182 F P +R + + L+ ++ + + L+ +++ G Sbjct: 86 FVDMDPPEHMHQRSMVEPTFTP---------EAVKNLQPYIQRTVDDLLEQMKQKGCANG 136 Query: 183 HFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRY 242 + + + V + I G + N E L+ N G A Sbjct: 137 PVDLVKEFALPVPSYIIYTLLGVPF--NDLEYLTQQNAIRTNGSSTAREASA-------- 186 Query: 243 LPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQL 302 N++ ++ +V++ + DI L + + ++ Sbjct: 187 -----------ANQELLDYLAILVEQRLVEPKD----DIISKLCTEQVKPGNIDKSDA-- 229 Query: 303 SDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDR 362 + I L AG T+ I+ + L +P +++ Sbjct: 230 -----VQIAFLLLVAGNATMVNMIALGVATLAQHPDQLAQLK------------------ 266 Query: 363 SHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWV 422 ++ F+ E R+ + I + D + + + + N D++++ Sbjct: 267 ANPSLAPQFVEELCRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFE 326 Query: 423 NPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV---E 479 NP EF R P + FG G +CI E +A+ E+ + L Q+ + Sbjct: 327 NPDEFNMNRKWPPQDP---------LGFGFGDHRCIAEHLAKAELTTVFSTLYQKFPDLK 377 Query: 480 FSVPLGVKVDMTPI 493 +VPLG K++ TP+ Sbjct: 378 VAVPLG-KINYTPL 390 >4XE3-A nrPDB Length = 407 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 66/322 (20%), Positives = 118/322 (36%), Gaps = 65/322 (20%) Query: 204 GRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRY------------LPNPSLNAF 251 RR + + SLV+ + ++V G+PAD + L +P + F Sbjct: 114 ARRVEEMRPRVRSLVD--SLLDDMVAHGSPADLVEFLAVPFPVAVICELLGVPLEDRDLF 171 Query: 252 KDLNEKFYSFMQKMVKEHYKTFEK---------GHIRD-ITDSLIEHCQEKQLDENANVQ 301 + ++ S + E + + RD T+ L+ L + + Sbjct: 172 RTFSDAMLSSTRLTAAEIQRVQQDFMVYMDGLVAQRRDAPTEDLLGALA---LATDNDDH 228 Query: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSD 361 L+ +I+N+ + L AG +T I+ + L+ +RK E L ++D Sbjct: 229 LTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLT----ERKRYESL-----------VAD 273 Query: 362 RSHLPYMEAFILETFRHSSFVPFT-IPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 420 + +P A + E R++ V T D L + G V+ N D+++ Sbjct: 274 PALVP---AAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASANRDEEV 330 Query: 421 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 480 + + E R P I FG G CIG + R E+ L+ L++R Sbjct: 331 FDHADELDFHRERNP-----------HIAFGHGAHHCIGAQLGRLELQEALSALVRRF-- 377 Query: 481 SVPLGVKVDMT-PIYGLTMKHA 501 +D+ P+ GL K Sbjct: 378 -----PTLDLAEPVAGLKWKQG 394 >3ABA-A nrPDB Length = 403 Score = 156 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 57/358 (15%), Positives = 109/358 (30%), Gaps = 65/358 (18%) Query: 147 IASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRR 206 +A + L ++ + + L + A G + + +V +++ + FG Sbjct: 102 LAKEFTVRRMQALRPNIQRIVD---EHLDAIEARGGPVDLVKTFANAVPSMVISDLFGVP 158 Query: 207 YDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMV 266 E + + + + + + ++V Sbjct: 159 V-ERRAEFQDIAEAMMRVDQDAAAT--------------------EAAGMRLGGLLYQLV 197 Query: 267 KEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAI 326 +E D+ +LI E+ + + D ++N L A DT I Sbjct: 198 QERRANP----GDDLISALIT-------TEDPDGVVDDMFLMNAAGTLLIAAHDTTACMI 246 Query: 327 SWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTI 386 L+ +P ++E+ V + E R+ + F Sbjct: 247 GLGTALLLDSPDQLALLREDPSLV------------------GNAVEELLRYLTIGQFGG 288 Query: 387 PHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEK 446 TRD L G I KG V + + D P F R P Sbjct: 289 ERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITRRPAP----------- 337 Query: 447 VIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCE 504 + FG G +CIG+ +AR E+ + L +R+ + L V+ + + E Sbjct: 338 HLAFGFGAHQCIGQQLARIELQIVFETLFRRLP-GLRLAKPVEELRFRHDMVFYGVHE 394 >2FR7-A nrPDB Length = 412 Score = 155 bits (392), Expect = 4e-38, Method: Composition-based stats. Identities = 55/255 (21%), Positives = 90/255 (35%), Gaps = 36/255 (14%) Query: 240 LRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENAN 299 L NAF NE S +++ E+ ++ C D Sbjct: 177 LLPYAGLVFNAFGPPNELRQSAIERSAPHQAYVAEQCQRPNLAPGGFGACIHAFSDTG-- 234 Query: 300 VQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRL 359 +++ E+ +V L AG DT I+ ++ L P +++ + Sbjct: 235 -EITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRADPS----------- 282 Query: 360 SDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 419 E R S V T +TTRD L G I +G V + N D + Sbjct: 283 -------LARNAFEEAVRFESPVQ-TFFRTTTRDVELAGATIGEGEKVLMFLGSANRDPR 334 Query: 420 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV- 478 W +P + R + + FG G C+G+ +AR E + LA L ++V Sbjct: 335 RWDDPDRYDITRK-----------TSGHVGFGSGVHMCVGQLVARLEGEVVLAALARKVA 383 Query: 479 --EFSVPLGVKVDMT 491 E + PL + + T Sbjct: 384 AIEIAGPLKRRFNNT 398 >6B11-A nrPDB Length = 440 Score = 155 bits (391), Expect = 5e-38, Method: Composition-based stats. Identities = 69/394 (17%), Positives = 138/394 (35%), Gaps = 73/394 (18%) Query: 126 DSGPVWAARRR-LAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLIS-TLQELMAGPGH 183 D PVW R+ + L ++ PA + ++ + L++ + A GH Sbjct: 85 DGAPVWLISRQDHVRALLADPRVSIHPAKLPRLSPSDGEAEASRSLLTLDPPDHGALRGH 144 Query: 184 FNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYL 243 F P + RR + +V ++ G+ AD + L Sbjct: 145 FIPEFGL--------------RRVRELRPSVEQIV--TGLLDDLTARGDEADLLADF-AL 187 Query: 244 PNPSLNAFKDLNEKF--YSFMQKMVKEHYKTFEKGHI-------RDITDSLIEHCQEKQL 294 P + + L+ + + Q+ ++ + RD D LI ++ Sbjct: 188 PMATQVICRLLDIPYEDRDYFQERTEQATRPAAGEEALEALLELRDYLDRLISGKTGRES 247 Query: 295 DENA---------NVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQE 345 + LS +++ + L AG +T + ++ S++ L+ +P R++ Sbjct: 248 GDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMSVLVLLQHPTAWREL-- 305 Query: 346 ELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGR 405 + + + E R+ S + + S T D + G I G Sbjct: 306 ----------------TVNPGLLPGAVDELLRYLS-IADGLRRSATADIEIDGHTIRAGD 348 Query: 406 CVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARW 465 + N D+ ++ P F R + + + FG G +C+G+ +AR Sbjct: 349 GLVFLLAAANRDEAVFSEPEAFDIHR-----------SARRHVAFGYGPHQCLGQNLARM 397 Query: 466 EVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMK 499 E+ + L +L+R+ P T + GL +K Sbjct: 398 ELEVALGAVLERLPALRPT------TDVAGLRLK 425 >3WVS-A nrPDB Length = 401 Score = 154 bits (390), Expect = 6e-38, Method: Composition-based stats. Identities = 54/298 (18%), Positives = 101/298 (33%), Gaps = 57/298 (19%) Query: 205 RRYDHNHQELLSLVNLNNNFGEVVGSGNPADFI-----PI-------LRYLPNPSLNAFK 252 RR + ++ L + +++ G PAD + PI L +P F Sbjct: 112 RRVEELRPKVHDLAHR--LIDDMLAKGEPADLVADYALPIPTTVICELLGVPFEDREKFG 169 Query: 253 DLNEKFYSFMQKMVKEHYKTFE----------KGHIRDITDSLIEHCQEKQLDENANVQL 302 + S +E D LI E + ++ +L Sbjct: 170 RWTDAILSTSTLNPEEGRVKRMELVGYIGGIIAARRAQPADDLISGMIEARDVQD---KL 226 Query: 303 SDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDR 362 +++++++ + L AG +T + I + L+ P+ +++ ++ + Sbjct: 227 TEQELLDHCIGLLIAGHETTASQIPSFVYALLDQPQHWKRLLDDPE-------------- 272 Query: 363 SHLPYMEAFILETFRHSSFVP-FTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLW 421 + + + E FR P D + G + G V V N D + Sbjct: 273 ----LIPSAVEELFRFVPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVALGAANRDGLRF 328 Query: 422 VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 +P E +R S I FG G C+G +AR E+ L LL+R+ Sbjct: 329 EDPEEIKLDR-----------PSNHHIGFGHGIHHCLGAPLARLELQEALRALLERLP 375 >4Z5Q-A nrPDB Length = 423 Score = 154 bits (389), Expect = 7e-38, Method: Composition-based stats. Identities = 79/450 (17%), Positives = 149/450 (33%), Gaps = 96/450 (21%) Query: 41 PGPWGWPLIGH-MLTLGKNPHLALSRMSQQYGDVLQIRI-GSTPVVVLSGLDTIRQALVR 98 P P +P G L L ++ GD +++++ P +++ D R L Sbjct: 33 PAPVAYPFTGSEGLELSQSYAKLFED-----GDPIRVQLPFGEPAWLVTRYDDARFVLTD 87 Query: 99 QG-DDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSC 157 + S P R L I S A Sbjct: 88 RRFSRHLATQRDEPRMTP-RAVPESILTMDPPDHTRLRTLVSKAFTPRRIESKRA----- 141 Query: 158 YLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSL 217 + + A L++ + + P + + VT VIC + Sbjct: 142 ----WIGELAAGLVADM-KAGGAPAELVGSYALAIPVT-VICELL--------------- 180 Query: 218 VNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEK-------FYSFMQKMVKEHY 270 G P D LR + +L+ + +E+ + + +VKE Sbjct: 181 -------------GVPEDDRTRLRGWCDAALSTGELTDEECVQSFMDLQKYFEDLVKERR 227 Query: 271 KTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330 D+T +LIE +A+ +L++ ++I + + + GF+T + IS + Sbjct: 228 AEP----RDDLTSALIEA-------RDAHDRLAEPELIGLCISILIGGFETTASEISSFV 276 Query: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTI-PHS 389 L + ++ +D +P A + E R F I P Sbjct: 277 HVLQQRRELWTRL---------------CADPEAIP---AAVEELLRFVPFAANGISPRY 318 Query: 390 TTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVII 449 D ++ G + +G V V+ +N D ++ N E + +R + ++ Sbjct: 319 ALEDMTVGGVLVREGEPVIVDTSAVNRDGLVFDNADEVVIDR-----------ADNRHMV 367 Query: 450 FGMGKRKCIGETIARWEVFLFLAILLQRVE 479 FG G C+G +AR E+ L L++ + Sbjct: 368 FGHGAHHCLGAHLARVELQEALKALVEGMP 397 >5XJN-A nrPDB Length = 455 Score = 154 bits (388), Expect = 1e-37, Method: Composition-based stats. Identities = 77/457 (16%), Positives = 149/457 (32%), Gaps = 94/457 (20%) Query: 58 NPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKG---------RPD 108 NP A + Q+ + RIG V++ D I+ + F R Sbjct: 63 NPFPAYKELRQEEPVMFDERIG---YWVVTKYDDIKTTF-DDWETFSSENAQAPVRKRGP 118 Query: 109 LYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAE 168 T ++++G ++S S + R+ K+F+ A LE + Sbjct: 119 QAT-QIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRYKA------LEPDIRAMVI 171 Query: 169 VLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVV 228 + + G + ++ I +S+V+ + + Sbjct: 172 DRVEKMLANDQHVGDMVSDLAYDIPTITILTLIG----------ADISMVDTYKRWSDSR 221 Query: 229 GSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEH 288 + D +P+ +++ Q+MV + + +T L+ Sbjct: 222 AAMTWGDLSDE-EQIPHAHNLV------EYWQECQRMVADAHAHGGDN----LTADLVRA 270 Query: 289 CQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELD 348 QE +++D +I +++ L AG +T TT IS L+ +P + I E Sbjct: 271 QQE-------GQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILE--- 320 Query: 349 TVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVF 408 + + A + E R+S + +DT + G I +G V Sbjct: 321 ---------------NPKLIPAAVDEVLRYSGSI-VGWRRKALKDTEIGGVAIKEGDGVL 364 Query: 409 VNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVF 468 + N D+ + N EF R + + + FG G C+G +A+ + Sbjct: 365 LLMGSANRDEARFENGEEFDISR----------ANAREHLSFGFGIHYCLGNMLAKLQAK 414 Query: 469 LFLAILLQ-----------------RVEFSVPLGVKV 488 + L + + + F VP V V Sbjct: 415 ICLEEVTRLVPSLHLVADKAIGFRENLSFRVPTSVPV 451 >6GMF-A nrPDB Length = 397 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 67/443 (15%), Positives = 139/443 (31%), Gaps = 71/443 (16%) Query: 52 MLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYT 111 + +NP+ + + + V +++ + + + + L F R + Sbjct: 9 APEVLRNPYALFAELRRT-SAVGRLQ--PQGFMAVGRYQDVARVLHD-AKGFSNRGWAAS 64 Query: 112 FTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLI 171 + + + P L++ + T LE + A L+ Sbjct: 65 LP-----RGVKWDTSMPPSIVQVDPPRHGKLRTL-VTKAFTPRTVAQLEPRIRDIAHELV 118 Query: 172 STLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSG 231 L+ + + V + + RR D Sbjct: 119 DGLRGKSTFEATVEVTVPMPMIVIAEMLGVAPERRADFKR-------------------- 158 Query: 232 NPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQE 291 D + L + + + ++FY++ +++ + + D+ L+ Sbjct: 159 WSDDMVGSLALVRVGNAAQLERSTQEFYAYFSEVL----EERRREPREDLISQLLAA--- 211 Query: 292 KQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVI 351 E +L+ ++++ L AG +T T+ I +L+ L +P Q +L V Sbjct: 212 ----EVDGEKLTAGEVLSFANTLLIAGNETTTSLIGNALVALTDHPEQLAAAQADLSLV- 266 Query: 352 GRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQ 411 A + E R+ S I T D + IP V Sbjct: 267 -----------------PAVVEEVLRYESPAQC-IFRQTMTDVEIGDERIPARSVVLPLL 308 Query: 412 WQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFL 471 N D+ + +P F R ++ + FG+ CIG +AR E + L Sbjct: 309 ASANRDESRFPDPDRFDIHR-----------DTKGHLAFGLDIHFCIGAPLARLEAKVML 357 Query: 472 AILLQRVEFSVPLGVKVDMTPIY 494 +LL R+ + +V +P + Sbjct: 358 EVLLARLGDIQRVSQEVSWSPSF 380 >6GK6-A nrPDB Length = 411 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 53/263 (20%), Positives = 92/263 (34%), Gaps = 44/263 (16%) Query: 229 GSGNPADFIPILRYLPNPSLNAFKDL---------NEKFYSFMQKMVKE---HYKTFEKG 276 P I L LP F+ + +F Q +V+E +++ Sbjct: 146 AFPLPTAVIAELLGLPVEDRGRFRRWTKILLAPAKDREFVERAQPVVEEFAAYFRALADA 205 Query: 277 HIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMN 336 + D LI L E +LS ++ ++V L AG +T I+ ++ L+ + Sbjct: 206 RRKAPRDDLISGLL---LAEEQEHKLSPAELSSMVFLLLVAGHETTVHLIASGMLLLLSH 262 Query: 337 PRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSL 396 P +R++ E+ V + + E R + + D L Sbjct: 263 PAERRRLDEDPGLV------------------GSAVEEALRCEGPAELSTIRWSLEDIEL 304 Query: 397 KGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRK 456 G +P G V N D + + +P F R + I FG G Sbjct: 305 FGARVPAGEGVAAGLLAANRDPQHFPDPDRFDIGR-----------SPNRHIGFGGGIHF 353 Query: 457 CIGETIARWEVFLFLAILLQRVE 479 C+G +AR E + + LL+R+ Sbjct: 354 CLGAMLARIEAAIAFSTLLRRLP 376 >5GWE-A nrPDB Length = 405 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 77/457 (16%), Positives = 149/457 (32%), Gaps = 94/457 (20%) Query: 58 NPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKG---------RPD 108 NP A + Q+ + RIG V++ D I+ + F R Sbjct: 13 NPFPAYKELRQEEPVMFDERIG---YWVVTKYDDIKTTF-DDWETFSSENAQAPVRKRGP 68 Query: 109 LYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAE 168 T ++++G ++S S + R+ K+F+ A LE + Sbjct: 69 QAT-QIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRYKA------LEPDIRAMVI 121 Query: 169 VLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVV 228 + + G + ++ I +S+V+ + + Sbjct: 122 DRVEKMLANDQHVGDMVSDLAYDIPTITILTLIG----------ADISMVDTYKRWSDSR 171 Query: 229 GSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEH 288 + D +P+ +++ Q+MV + + +T L+ Sbjct: 172 AAMTWGDLSDE-EQIPHAHNLV------EYWQECQRMVADAHAHGGDN----LTADLVRA 220 Query: 289 CQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELD 348 QE +++D +I +++ L AG +T TT IS L+ +P + I E Sbjct: 221 QQE-------GQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILE--- 270 Query: 349 TVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVF 408 + + A + E R+S + +DT + G I +G V Sbjct: 271 ---------------NPKLIPAAVDEVLRYSGSI-VGWRRKALKDTEIGGVAIKEGDGVL 314 Query: 409 VNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVF 468 + N D+ + N EF R + + + FG G C+G +A+ + Sbjct: 315 LLMGSANRDEARFENGEEFDISR----------ANAREHLSFGFGIHYCLGNMLAKLQAK 364 Query: 469 LFLAILLQ-----------------RVEFSVPLGVKV 488 + L + + + F VP V V Sbjct: 365 ICLEEVTRLVPSLHLVADKAIGFRENLSFRVPTSVPV 401 >4YZR-A nrPDB Length = 405 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 54/355 (15%), Positives = 109/355 (30%), Gaps = 73/355 (20%) Query: 125 PDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHF 184 P R L T L + + AE L+ +++ Sbjct: 93 AKDTPDHTRLRSLVHQAFTP---------RTIENLRGSIEQIAEQLLDEMEKENKADIMK 143 Query: 185 NPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLP 244 + + V + + I R ++V+ + E+ Sbjct: 144 SFASPLPFIVISELMGIPKEDRSQFQIW-TNAMVDTSEGNRELT---------------- 186 Query: 245 NPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSD 304 +F ++ K++ + + D LI E +LS+ Sbjct: 187 -------NQALREFKDYIAKLIHDRRIKPK--------DDLISKLVHA---EENGSKLSE 228 Query: 305 EKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSH 364 +++ +++ L AG +T + + L+ + + K++++ + + Sbjct: 229 KELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIA------------- 275 Query: 365 LPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNP 424 + E R++S V D + KG I +G +F+ N D + NP Sbjct: 276 -----TAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENP 330 Query: 425 SEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 R + I FG G C+G +AR E + LL+R Sbjct: 331 EILNINR-----------SPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFP 374 >3A50-A nrPDB Length = 411 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 82/437 (18%), Positives = 150/437 (34%), Gaps = 80/437 (18%) Query: 54 TLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALV--RQGDDFKGR-PDLY 110 T +NPH A + + + V ++ + PV +L+ +R+A V R D++ R P+ Sbjct: 17 TFWQNPHPAYAALRAE-DPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHRLPEDQ 75 Query: 111 TFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVL 170 + + M D P R+L + LE +++ A+ L Sbjct: 76 RADMPATPTPMMILMDP-PDHTRLRKLVGRSFTVRRMNE---------LEPRITEIADGL 125 Query: 171 ISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGS 230 ++ L GP Y VIC + D + + + V+ Sbjct: 126 LAGLP--TDGPVDLM-REYAFQIPVQVICELLGLPAEDRDD---------FSAWSSVLVD 173 Query: 231 GNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQ 290 +PAD K + ++ +++ + D+L+ Sbjct: 174 DSPADDK--------------NAAMGKLHGYLSDLLERKRTEPD--------DALLSSLL 211 Query: 291 EKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTV 350 + + +LS E+++ + + L AG +T I ++ L+ +P QRK+ E ++ Sbjct: 212 A--VSDMDGDRLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPD-QRKLLAEDPSL 268 Query: 351 IGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVN 410 I + E R S V T D + G IP G V + Sbjct: 269 ISS-----------------AVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLG 311 Query: 411 QWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLF 470 N D P R + + FG G C+G +AR E + Sbjct: 312 LAAANRDADWMPEPDRLDITR-----------DASGGVFFGHGIHFCLGAQLARLEGRVA 360 Query: 471 LAILL-QRVEFSVPLGV 486 + L R E ++ +G+ Sbjct: 361 IGRLFADRPELALAVGL 377 >5FOI-A nrPDB Length = 408 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 65/424 (15%), Positives = 140/424 (33%), Gaps = 84/424 (19%) Query: 80 STPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSM-SFSPDSGPVWAARRRLA 138 +P ++S + +R LV +G S P RR+ Sbjct: 55 GSPTWLVSRYEHVRALLVDPRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHTRLRRMF 114 Query: 139 QNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVI 198 + + +E+ V + L++ P + T VI Sbjct: 115 ISAFS-----VRQVETMRPEIEKIVDGILDRLLAL------EPPVDILTHLALPMSTQVI 163 Query: 199 CAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKF 258 C + + +E E+ P+ + + Sbjct: 164 CHLL---GVPYEDREF------FQERSELASR---------------PNDDRSMPALIEL 199 Query: 259 YSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAG 318 ++ +V+ + G L+ ++L + +++ ++++N + L AG Sbjct: 200 VEYLDGLVRTKTAHPDTG--------LLGTAVTERLLKG---EITHQELVNNAVLLLAAG 248 Query: 319 FDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRH 378 +T ++ S++ L+ +P +++E+ + M + E R+ Sbjct: 249 HETSANQVTLSVLTLLRHPETAAELREQPE------------------LMPNAVDELLRY 290 Query: 379 SSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGA 438 S + + + T D L I G + + NHD + + F R Sbjct: 291 HS-IADGLRRAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHR------- 342 Query: 439 IDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDM------TP 492 + + FG G +C+G+ +AR E+ + L L +RV ++ L + D +P Sbjct: 343 ----PARHHVAFGYGPHQCLGQNLARLEMEVTLGKLFRRVP-ALRLAQEPDALRVRQGSP 397 Query: 493 IYGL 496 I+G+ Sbjct: 398 IFGI 401 >6A7I-A nrPDB Length = 411 Score = 152 bits (384), Expect = 3e-37, Method: Composition-based stats. Identities = 52/268 (19%), Positives = 92/268 (34%), Gaps = 45/268 (16%) Query: 229 GSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFE---------KGHIR 279 P + I L + K+L EKF+S + + Sbjct: 146 AYPLPMNVISELMGVDAADHPRLKELFEKFFSTQTPPEEVPQMMADLGALFTKIVDAKRT 205 Query: 280 DITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRV 339 + D L L+DE+I+N + + AG +T + I + L +P Sbjct: 206 NPGDDLTSALIAA---SENGDHLTDEEIVNTLQLIIAAGHETTISLIVNVVEALQTHPEQ 262 Query: 340 QRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGF 399 ++K+ L+ IG + I ET R ++ + T D + Sbjct: 263 RKKV---LNGEIG---------------WDGVIEETLRWNTPTSHVLIRFATEDIEVGDK 304 Query: 400 YIPKGRCVFVNQWQINHDQKLW-VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCI 458 +PKG + ++ + D++ + EF R + I FG G C Sbjct: 305 ILPKGEGLIISFGALGRDEEQYGPTAGEFDATR-----------TPNRHIAFGHGPHVCP 353 Query: 459 GETIARWEVFLFLAILLQRV---EFSVP 483 G ++R E + L L +R + +VP Sbjct: 354 GAALSRLEAGIALPALYERFPELDLAVP 381 >4WPZ-A nrPDB Length = 397 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 63/339 (18%), Positives = 109/339 (32%), Gaps = 51/339 (15%) Query: 166 EAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFG 225 E L++ M P H + V + T R +LL + Sbjct: 73 ETGKLMNESLVGMDAPEHTRLRKLVTKAFTARRVETL-RPRITELVGQLLDELETLPRPV 131 Query: 226 EVV---GSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFE-------- 274 ++V P I L +P + F + Q++V++ T Sbjct: 132 DLVKNFSVPLPVRVICELLGVPAGDQDTFHAWSNALLGDWQQVVEKEAATVSLVNYFGEL 191 Query: 275 -KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYL 333 + D LI + + L++ +II + + + AG +T IS L+ L Sbjct: 192 IAVKRENPADDLISELIA---ISDGDSTLTEREIIALSIGILSAGHETTANQISMFLVTL 248 Query: 334 VMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFT--IPHSTT 391 + NP K+++ + + + E R IP TT Sbjct: 249 LHNPEELDKLRDNREAI------------------PKAVDELLRFVPLTTTGGIIPRLTT 290 Query: 392 RDTSL-KGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIF 450 + L G +P G V N D +++ + R P + F Sbjct: 291 AEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLNVTRENNP-----------HLAF 339 Query: 451 GMGKRKCIGETIARWEVFLFLAILLQRV---EFSVPLGV 486 G G C+G +AR E+ L +L R+ +VP Sbjct: 340 GAGIHHCLGAQLARIELQEALGAILDRMPQVRLAVPESE 378 >5EX6-C nrPDB Length = 434 Score = 151 bits (382), Expect = 5e-37, Method: Composition-based stats. Identities = 81/454 (17%), Positives = 139/454 (30%), Gaps = 112/454 (24%) Query: 71 GDVLQIRIGS----TPVVVLSGLDTIRQAL-----------VRQGDDFKGRPDLYTFTLI 115 G++ ++R+GS + +G D +RQ L + D+ G+ L+ Sbjct: 62 GELTRVRLGSGADAEHTWLATGHDVVRQVLGDHTRFSTRRRFDRNDEIGGKGVFRPRELV 121 Query: 116 SNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQ 175 N P RRL G + Y+E+ V++ + + Sbjct: 122 GN-----LMDYDPPEHTRLRRLLAPGFTH-----RKIRRMAPYIEQIVTERLDEM----- 166 Query: 176 ELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPAD 235 E P V V+C + G P D Sbjct: 167 EREGSPADLIELFADEV-PGPVLCELL----------------------------GVPRD 197 Query: 236 FIPILRYLPNPSL------NAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHC 289 + L + L E F ++ MV K D D LI Sbjct: 198 DRAMFLQLCHRHLDASLSGRRRAAAGEAFSRYLVTMVARERK--------DPGDGLIGMV 249 Query: 290 QEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDT 349 + D ++DE++ + + + AG D ++ I ++ L+ NP + Sbjct: 250 VAEHGDT-----VTDEELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAAL------ 298 Query: 350 VIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFV 409 R +P E + E R+ + P + D+++ I G V Sbjct: 299 ------------RGDVPAAERAVDELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLC 346 Query: 410 NQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFL 469 + N D L + R P + FG G C+G +AR E+ + Sbjct: 347 SLPTANRDPALLPDADRLDVTREAVP-----------HVAFGHGVHHCLGAALARLELRI 395 Query: 470 FLAILLQRV---EFSVPLGVKV--DMTPIYGLTM 498 L +R + P G TP YG++ Sbjct: 396 AYTALWRRFPDLRLADPDGATEFRLSTPAYGISR 429 >4DO1-A nrPDB Length = 410 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 51/255 (20%), Positives = 89/255 (34%), Gaps = 36/255 (14%) Query: 240 LRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENAN 299 L NAF NE + +++ E+ ++ C D Sbjct: 175 LLPYAGLVFNAFGPPNELRQTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTG-- 232 Query: 300 VQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRL 359 +++ ++ +V L AG DT I ++ L P +++ Sbjct: 233 -EITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRL---------------- 275 Query: 360 SDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQK 419 RS E R S V T +TTR+ L G I +G V + N D + Sbjct: 276 --RSDPTLARNAFEEAVRFESPVQ-TFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPR 332 Query: 420 LWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV- 478 W +P + R + + FG G C+G+ +AR E + L+ L ++V Sbjct: 333 RWSDPDLYDITRK-----------TSGHVGFGSGVHMCVGQLVARLEGEVMLSALARKVA 381 Query: 479 --EFSVPLGVKVDMT 491 + P+ + + T Sbjct: 382 AIDIDGPVKRRFNNT 396 >3R9C-A nrPDB Length = 418 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 59/348 (16%), Positives = 109/348 (31%), Gaps = 55/348 (15%) Query: 161 EHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNL 220 + + E L+ L + + GP VIC + D S + Sbjct: 122 KRLEPEITALVDQLLDAVDGPEFNLIDNLAYPLPVAVICRLLGVPIEDEPKFSRASALLA 181 Query: 221 NNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRD 280 + +G +D + +++ ++ E +T D Sbjct: 182 AALDPFLALTGETSDL-----------FDEQMKAGMWLRDYLRALIDERRRTP----GED 226 Query: 281 ITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQ 340 + L+ E + QL++++II L AG +T I+ + + ++ P Sbjct: 227 LMSGLVAV-------EESGDQLTEDEIIATCNLLLIAGHETTVNLIANAALAMLRTPGQW 279 Query: 341 RKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFY 400 + + A I ET R+ V + D ++ Sbjct: 280 AALAADGSR------------------ASAVIEETMRYDPPVQL-VSRYAGDDLTIGTHT 320 Query: 401 IPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGE 460 +PKG + + + D + P F P+R + + FG G C+G Sbjct: 321 VPKGDTMLLLLAAAHRDPTIVGAPDRFDPDR-----------AQIRHLGFGKGAHFCLGA 369 Query: 461 TIARWEVFLFLAILLQRV---EFSVPLGVKVDMTPIYGLTMKHACCEH 505 +AR E + L L R S K ++T T+ A H Sbjct: 370 PLARLEATVALPALAARFPEARLSGEPEYKRNLTLRGMSTLSIAVHHH 417 >6F0B-A nrPDB Length = 395 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 79/428 (18%), Positives = 141/428 (32%), Gaps = 77/428 (17%) Query: 80 STPVVVLSGLDTIRQALVRQG-DDFKGRPDLYTFTLISNGQSMS--FSPDSGPVWAARRR 136 TP V SG + +R L + RP+ T Q+ + F P R Sbjct: 37 GTPAHVFSGYEDVRTVLQDRRFSSDSRRPNFTELTPTLQSQAAAPPFVRTDNPDHRRLRG 96 Query: 137 LAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTN 196 +IA + L + + + ++ L E A P V V+ Sbjct: 97 ---------TIAREFLPKHIELLRPAIREIVQGVLDGLAE-TAPPQDMLEAFAVPVASAT 146 Query: 197 VICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNE 256 V + + LL+ VGS + F+ L E Sbjct: 147 VFRLLG----IPAEDRALLT--RCVKGVVSAVGSE-------------DEGAEVFRTLGE 187 Query: 257 KFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFG 316 ++ +V++ + E DSLI E QL+ + I ++L L Sbjct: 188 ----YIGGLVQDPSELPE--------DSLIRRLVTGPYQEK---QLTFHETIGVILMLIV 232 Query: 317 AGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETF 376 G+DT + IS SL+ + P + E + + + E Sbjct: 233 GGYDTTASTISLSLVSYALQPEKFSVVHEHPERI------------------PLLVEELL 274 Query: 377 RHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPD 436 R+ + + T D + G + G+ V N D+ ++ NP E +R Sbjct: 275 RYHTVSQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR----- 329 Query: 437 GAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGL 496 S + FG G +C+G+ +AR E+ + +++R+ + L ++ P Sbjct: 330 ------PSVPHVGFGYGPHQCVGQALARVELQEAIPAVIRRLP-GMRLACALEDLPFRHD 382 Query: 497 TMKHACCE 504 + E Sbjct: 383 MATYGIHE 390 >4Z5P-A nrPDB Length = 400 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 44/277 (15%), Positives = 85/277 (30%), Gaps = 44/277 (15%) Query: 223 NFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDIT 282 + + I L +P F+ +E S +E IR Sbjct: 136 DIVRDLAQPFTIAVICRLLGVPYEDRGRFQHWSEVIMSTTAYSKEE--AVSADASIRAYL 193 Query: 283 DSLIEHCQEKQLDE---------NANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYL 333 L+ + D+ + + +L+++++I + L AG +T + + L Sbjct: 194 ADLVSARRAAPHDDLLGVLVSARDDDDRLTEDELITFGVTLLVAGHETSAHQLGNMVYAL 253 Query: 334 VMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFV-PFTIPHSTTR 392 + + ++E+ + + + E R Sbjct: 254 LTHEDQLSLLREQPE------------------LLPRAVEELLRFVPLGNGVGNARIALE 295 Query: 393 DTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGM 452 D L G + G V N D + + +P R P + FG Sbjct: 296 DVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITREKNP-----------HLAFGH 344 Query: 453 GKRKCIGETIARWEVFLFLAILLQRV---EFSVPLGV 486 G C+G +AR E+ + + LL+R +VP Sbjct: 345 GAHYCLGAQLARMELRVAIGGLLERFPGLRLAVPADQ 381 >1Z8P-A nrPDB Length = 404 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 70/471 (14%), Positives = 145/471 (30%), Gaps = 89/471 (18%) Query: 54 TLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVR-------QGDDFKGR 106 + + + + + + V +R +++G D + AL + Sbjct: 11 SFHVDWYRTYAELRET-APVTPVRFLGQDAWLVTGYDEAKAALSDLRLSSDPKKKYPGVE 69 Query: 107 PDLYTFTLISNGQSMSFSPDSG----PVWAARRRLAQNGLKSFSIASDPASSTSCYLEEH 162 + + F+ + G P R+L + E Sbjct: 70 VEFPAYLGFPEDVRNYFATNMGTSDPPTHTRLRKLVSQEFTVRRV-------------EA 116 Query: 163 VSKEAEVLISTLQELMAGPGHFNPYRYVVV-SVTNVICAICFGRRYDHNHQELLSLVNLN 221 + E + + L + + G + VIC + D Sbjct: 117 MRPRVEQITAELLDEVGDSGVVDIVDRFAHPLPIKVICELL---GVDEK---------YR 164 Query: 222 NNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDI 281 FG D + +F+ +V+ E G D+ Sbjct: 165 GEFGRWSSEILVMD---------PERAEQRGQAAREVVNFILDLVERRR--TEPGD--DL 211 Query: 282 TDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQR 341 +LI ++ ++ + +LS +++ +I L L AGF++ + I L+ +P Sbjct: 212 LSALI------RVQDDDDGRLSADELTSIALVLLLAGFESSVSLIGIGTYLLLTHPDQLA 265 Query: 342 KIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYI 401 ++ + + + E R+ + P T + + G I Sbjct: 266 LVRRDPSA------------------LPNAVEEILRYIAP-PETTTRFAAEEVEIGGVAI 306 Query: 402 PKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGET 461 P+ V V N D K + +P F R + + FG G C+G Sbjct: 307 PQYSTVLVANGAANRDPKQFPDPHRFDVTR-----------DTRGHLSFGQGIHFCMGRP 355 Query: 462 IARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS 512 +A+ E + L L R ++ LG+ D ++ ++ +H ++L Sbjct: 356 LAKLEGEVALRALFGRFP-ALSLGIDADDV-VWRRSLLLRGIDHLPVRLDG 404 >3P3Z-A nrPDB Length = 416 Score = 148 bits (373), Expect = 6e-36, Method: Composition-based stats. Identities = 46/280 (16%), Positives = 96/280 (34%), Gaps = 39/280 (13%) Query: 211 HQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHY 270 Q + L + +F + PA + L P + L+ + + + Sbjct: 136 EQLIDKLPQGDFDFVQHFPHPLPALVMCQLLGFPLEDYDTVGRLSIETNLGLALSNDQDI 195 Query: 271 KTFEKGHIRDITDSLIEHCQEKQLDENANVQ-----------LSDEKIINIVLDLFGAGF 319 + + + D L+ ++++++ ++ L D ++ +V + AG+ Sbjct: 196 LVKVEQGLGRMFDYLVAAIEKRKVEPGDDLTSDIVRAFHDGVLDDYELRTLVATVLVAGY 255 Query: 320 DTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHS 379 +T ++ ++ +P KI+E + + E R S Sbjct: 256 ETTNHQLALAMYDFAQHPDQWMKIKE------------------NPELAPQAVEEVLRWS 297 Query: 380 SFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAI 439 +P T D + G IP G VF+ + D +++ + F Sbjct: 298 PTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADADRFDITVKREA---- 353 Query: 440 DKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 I FG G C+G +AR E+ +A L R++ Sbjct: 354 ------PSIAFGGGPHFCLGTALARLELTEAVAALATRLD 387 >3TYW-A nrPDB Length = 417 Score = 147 bits (372), Expect = 7e-36, Method: Composition-based stats. Identities = 69/400 (17%), Positives = 127/400 (31%), Gaps = 79/400 (19%) Query: 85 VLSGLDTIRQALVR-QGDDFKGRPDLYTFTLISNGQSMSFSP---DSGPVWAARRRLAQN 140 V++ D +R+ L + RP F P P RR+ Sbjct: 57 VVTRYDDVRELLSDPRVSADIRRPGFPALGEGEQEAGARFRPFIRTDAPEHTRYRRMLLP 116 Query: 141 GLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSV-TNVIC 199 + ++ V + + ++ A G + +V T+VIC Sbjct: 117 AF-----TVRRVRAMRPAVQARVDEILDGML-------AAGGPVDLVSAYANAVSTSVIC 164 Query: 200 AICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFY 259 ELL + + F V + + N + + + Sbjct: 165 -------------ELLGIPRHDLEFFRDVTRISGSR---------NSTAEQVSEALGGLF 202 Query: 260 SFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGF 319 + +V E + + D LI L ++ E++++ + AG Sbjct: 203 GLLGGLVAERRE--------EPRDDLISKLVTDHLVPGN---VTTEQLLSTLGITINAGR 251 Query: 320 DTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHS 379 +T T+ I+ S + L+ P + +++++ D M A + E R Sbjct: 252 ETTTSMIALSTLLLLDRPELPAELRKDPD------------------LMPAAVDELLRVL 293 Query: 380 SFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAI 439 S D L G +P V NHD + + +P R Sbjct: 294 SVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHR-------- 345 Query: 440 DKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 + FG G +C+G+ +AR E+ + L LL+RV Sbjct: 346 ---TDNHHVAFGYGVHQCVGQHLARLELEVALETLLRRVP 382 >3SN5-A nrPDB Length = 491 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 78/470 (16%), Positives = 158/470 (33%), Gaps = 49/470 (10%) Query: 39 NPPGPWGW-PLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALV 97 PP G P +G L G NP L +++G V ++ V ++ + + L Sbjct: 14 EPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLC 73 Query: 98 RQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSC 157 G F + + + + G P G L+ ++ +S + Sbjct: 74 -HGKYFDWKKFHFALSAKAFGHRSI-DPMDGNTTENINDTFIKTLQGHAL-----NSLTE 126 Query: 158 YLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSL 217 + E++ + +S+ + A Y + + FGR + + Sbjct: 127 SMMENLQRIMRPPVSSNSKTAAWVTEGM-YSFCYRVMFEAGYLTIFGRDLTRRDTQKAHI 185 Query: 218 VNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGH 277 +N +NF + F ++ LP + EK + H ++ Sbjct: 186 LNNLDNFKQFDKV-----FPALVAGLPIHMFRTAHNAREKLAESL-----RHENLQKRES 235 Query: 278 IRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNP 337 I ++ + L +++ + ++ + A A WSL ++ NP Sbjct: 236 ISELIS--LRMFLNDTLSTFDDLEKAKTHLV-----VLWASQANTIPATFWSLFQMIRNP 288 Query: 338 RVQRKIQEELDTVI----------GRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIP 387 + EE+ + G ++ + LP +++ I E+ R SS Sbjct: 289 EAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS--LNI 346 Query: 388 HSTTRDTSL----KGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVL 443 + D +L + I K + + ++ D +++ +P F +R+L +G Sbjct: 347 RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTF 406 Query: 444 -------SEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGV 486 + FG G C G A E+ FL ++L E + G Sbjct: 407 YCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQ 456 >1CPT-A nrPDB Length = 428 Score = 146 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 74/421 (17%), Positives = 151/421 (35%), Gaps = 71/421 (16%) Query: 69 QYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMS--FSPD 126 ++ DV ++IG P + + + + L Q + + + ++ + + Sbjct: 56 KHADV--MQIGKQPGLFSNAEGS--EILYDQNN------EAFMRSISGGCPHVIDSLTSM 105 Query: 127 SGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNP 186 P A R L N + SI LEE++ + A+ + L + G F Sbjct: 106 DPPTHTAYRGLTLNWFQPASIRK---------LEENIRRIAQASVQRLLDF-DGECDFMT 155 Query: 187 YRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNP 246 + + V+ A+ + + +L L E A R + Sbjct: 156 DCALYYPLHVVMTALGVP---EDDEPLMLKLTQDFFGVHEPDEQAVAAP-----RQSADE 207 Query: 247 SLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEK 306 + F + FY + + + D ++ +LD N + D+ Sbjct: 208 AARRFHETIATFYDYFNGFTVDRRSCPK--------DDVMSLLANSKLDGNY---IDDKY 256 Query: 307 IINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLP 366 I + + AG DT +++ +++ L NP SD + +P Sbjct: 257 INAYYVAIATAGHDTTSSSSGGAIIGLSRNPEQLA---------------LAKSDPALIP 301 Query: 367 YMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSE 426 + + E R ++ V + + DT ++G I +G + ++ N D++++ NP E Sbjct: 302 RL---VDEAVRWTAPVKSFM-RTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDE 357 Query: 427 FLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGV 486 F RF + + FG G C+G+ +A+ E+ +F LL +++ G Sbjct: 358 FDITRFPN-----------RHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSGP 406 Query: 487 K 487 Sbjct: 407 P 407 >5Z9I-A nrPDB Length = 398 Score = 145 bits (365), Expect = 5e-35, Method: Composition-based stats. Identities = 70/358 (19%), Positives = 122/358 (34%), Gaps = 58/358 (16%) Query: 146 SIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGR 205 +I S+P +S + K E ++ P H V + T + A Sbjct: 46 AILSNPKVFSSDTMRLDPIKLDEAIVEGDFAHTDPPKHRRLRGLVDHAFTPSLVAK-MES 104 Query: 206 RYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPI--LRYLPNPSLNAFKDLNEKFYSFMQ 263 R ELL V + F V P I I L +P F+ +K + Sbjct: 105 RVHGIIHELLDGVEGKSQFDLVAEFAAPLPLIMISDLLGVPESDRALFRQWMDKMLDGSE 164 Query: 264 K----------------------MVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQ 301 K +++++ + + LI ++D + Sbjct: 165 KFESPETVLEQEEELHKELELLWEMRDYWHERAAESRKRPREDLISQLVHAEVD---GQK 221 Query: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSD 361 L+D +I NI L G T I+ +++ L +++ +D Sbjct: 222 LNDSQISNIANRLLVNGHLTTAMLIANTMLCLDAFSDQDARVR---------------AD 266 Query: 362 RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLW 421 RS +P A + E+ R+ S + + +T + + G IPK + + V N D++ + Sbjct: 267 RSLVP---ALLEESMRYMSPI-CGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQF 322 Query: 422 VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 P F R + FG G C+G +AR E + ILL R+ Sbjct: 323 EKPDVFDAGR-----------SPNAHLGFGRGIHFCLGRQLARMESKAAVEILLDRLP 369 >6FYJ-A nrPDB Length = 421 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 67/445 (15%), Positives = 148/445 (33%), Gaps = 74/445 (16%) Query: 49 IGHMLTLGKNPHLALSRMSQQY-GDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRP 107 I L + ++ + + D+ + R+ + + G + + + FK + Sbjct: 15 IDSTWRLMEEGYMYILNRRHSFNSDIFETRLLGKKAICMGGKEAA-EIFYDT-EKFKRKD 72 Query: 108 DLYTFTLIS-NGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKE 166 + + G++ + D G R+ + + + L + K+ Sbjct: 73 AAPNRVVQTLFGKNGVQALD-GQTHKHRKEMFMSIMSP---------DELEKLTDITKKQ 122 Query: 167 AEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGE 226 E+ + +++ Y + C G N + L+ N G Sbjct: 123 WEIAVDKWEQMD----KVILYEEAKEIMCRTACQWA-GVPVQENEVKRLT-----KNLGA 172 Query: 227 VVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHI-------R 279 + S L ++ E + + V++ + R Sbjct: 173 MFESAAAVGLKHWLG-------RHARNYEEIWIEELIDRVRDGKVNPPENTTLHKFSWYR 225 Query: 280 DITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRV 339 D+ +L++ ++INI+ + + I++ + L P Sbjct: 226 DLEGNLLDTETAAV------------EVINILRPIVA-----IAIFINFIALALHHYPEE 268 Query: 340 QRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGF 399 + K++ Y + F+ E R F PF + +D + KG+ Sbjct: 269 KEKLKS-----------------GDKKYSQMFVQEVRRFYPFFPFVVA-LVKKDFTWKGY 310 Query: 400 YIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIG 459 +G ++ + NHD ++W NP F P+RF +G+ + + + MG +C G Sbjct: 311 KFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRFAKWEGSPFSFIPQGGGDYFMG-HRCAG 369 Query: 460 ETIARWEVFLFLAILLQRVEFSVPL 484 E + + + L L R+++ VP Sbjct: 370 EWVTIEVMKVSLDYLTNRMDYEVPD 394 >1GWI-A nrPDB Length = 411 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 74/459 (16%), Positives = 134/459 (29%), Gaps = 101/459 (22%) Query: 71 GDVLQIRI-GSTPVVVLSGLDTIRQALV--------------RQGDDFKGRPDLYTFTLI 115 G + + + G PV ++ + L R+G+ D L Sbjct: 30 GPLAAVELPGGVPVWAVTHHAEAKALLTDPRLVKDINVWGAWRRGEIPA---DWPLIGLA 86 Query: 116 SNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQ 175 + G+SM G R L L ++ +++ + L+ L Sbjct: 87 NPGRSM--LTVDGAEHRRLRTLVAQALT---------VRRVEHMRGRITELTDRLLDELP 135 Query: 176 ELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPAD 235 A G + + + A G L L L F P + Sbjct: 136 ---ADGGVVDLKAAFAYPLPMYVVADLMGI----EEARLPRLKVLFEKFFST--QTPPEE 186 Query: 236 FIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLD 295 + L + S M V D+T +LI+ + Sbjct: 187 VVATL---------------TELASIMTDTVAAKRAAP----GDDLTSALIQASEN---- 223 Query: 296 ENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSR 355 L+D +I++ + + AG +T + I +++ L +P + + Sbjct: 224 ---GDHLTDAEIVSTLQLMVAAGHETTISLIVNAVVNLSTHPEQRALVLSGEAE------ 274 Query: 356 RPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIN 415 A + ET R S+ + D + IP G + V+ + Sbjct: 275 ------------WSAVVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALG 322 Query: 416 HDQKLW-VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAIL 474 D++ F R + I FG G C G ++R E + L L Sbjct: 323 RDERAHGPTADRFDLTR----------TSGNRHISFGHGPHVCPGAALSRMEAGVALPAL 372 Query: 475 LQRV---EFSVPLG-----VKVDMTPIYGLTMKHACCEH 505 R + +VP V ++ L ++ A H Sbjct: 373 YARFPHLDLAVPAAELRNKPVVTQNDLFELPVRLAHHHH 411 >5NWS-A nrPDB Length = 435 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 54/294 (18%), Positives = 97/294 (32%), Gaps = 37/294 (12%) Query: 204 GRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPI--LRYLPNPSLNAFKDLNEKFYSF 261 R D EL + + P I L +P L +++ S Sbjct: 147 ERIADRLLAELPRREEEDGTVDLLEHFAYPLSITVICELVGIPATDLERWREWGGDLVSM 206 Query: 262 MQKMVKEHYKTFEK-------GHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDL 314 + ++ + +TD L+ Q D+ +LSD + + ++L L Sbjct: 207 RPERLRHSFPVMIDYCHRLIEQRRAALTDDLLSELIRAQDDDGG--RLSDIETVTMILTL 264 Query: 315 FGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILE 374 AG +T I L+ +P ++++ + + E Sbjct: 265 VLAGHETSAHLIGNGTAALLTHPGQWALLRKDPA------------------LLPRAVHE 306 Query: 375 TFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 434 R V T D L G + +G V + N D + + +P R Sbjct: 307 LMRWCGSVHVARLRYATEDLELAGTPVARGDAVQLVLVSANFDPRHYSDPDRLDITR--- 363 Query: 435 PDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV-EFSVPLGVK 487 + +E + FG G C+G T+AR E + LA LL+ + ++ G Sbjct: 364 ----HQEGQAENHVGFGHGIHYCLGATLARQEGEVALARLLETYPDLALADGDP 413 >5XNT-A nrPDB Length = 411 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 55/352 (15%), Positives = 119/352 (33%), Gaps = 69/352 (19%) Query: 129 PVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYR 188 P RR L S+ E + + A+ LI + E + + Sbjct: 94 PEHRKRRSLLAAAFTPRSLQ---------NWEPRIQEIADELIEEMDEET----EIDIVQ 140 Query: 189 YVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSL 248 + + ++ + G L + +++ F+P + Sbjct: 141 SLASPLPIIVMSDLMGVPSKDRL--------LFKKWVDIL-------FLPFDKEKQEEVN 185 Query: 249 NAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKII 308 + +++Y ++ +V + DI L++ E +D++++ Sbjct: 186 ELKQVAAKEYYQYLYPIVVQKRLNP----ADDIISDLLKA-------EVDGEMFTDDEVV 234 Query: 309 NIVLDLFGAGFDTVTTAISWSLMYLV-MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPY 367 + + GAG +T + ++ S L+ + V +++ E LD V Sbjct: 235 RTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDLV----------------- 277 Query: 368 MEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEF 427 + E R+ F + + D L G + +G V V N D++++ + Sbjct: 278 -PQAVEEMLRYR-FNLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMFEDAFTL 335 Query: 428 LPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 R ++K + FG G C+G +AR E + L L++ + Sbjct: 336 NIHR----------PNNKKHLTFGNGPHFCLGAPLARLEAKIALTTFLKKFK 377 >2WIO-A nrPDB Length = 431 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 55/272 (20%), Positives = 85/272 (31%), Gaps = 47/272 (17%) Query: 223 NFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSF---------MQKMVKE----- 268 + +V+ P + L LP F D + + + + + Sbjct: 154 DLVDVLAFPLPVTIVAELLGLPPMDHEQFGDWSGALVDIQMDDPTDPALAERIADVLNPL 213 Query: 269 --HYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAI 326 + K D D LI ++D L DE+ N L AG T T + Sbjct: 214 TAYLKARCAERRADPGDDLISRLVLAEVD---GRALDDEEAANFSTALLLAGHITTTVLL 270 Query: 327 SWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTI 386 + L +P E D +P A + E R+ P + Sbjct: 271 GNIVRTLDEHPAHWDAAAE---------------DPGRIP---AIVEEVLRYRPPFP-QM 311 Query: 387 PHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEK 446 +TT+ T + G IP V N D +P F P R K Sbjct: 312 QRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSR---------KSGGAA 362 Query: 447 VIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 + FG G C+G +AR E + L ++ R Sbjct: 363 QLSFGHGVHFCLGAPLARLENRVALEEIIARF 394 >2ZQJ-A nrPDB Length = 417 Score = 142 bits (357), Expect = 5e-34, Method: Composition-based stats. Identities = 71/436 (16%), Positives = 150/436 (34%), Gaps = 58/436 (13%) Query: 49 IGHMLTLGKNPHLALSRMSQQY-GDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRP 107 + + LTL K +L + +++Y D+ Q R+ + ++G + + + Sbjct: 11 LDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGKNFICMTGAEAAK-VFYDTDRFQRQNA 69 Query: 108 DLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEA 167 G + D R++ L + L E +++E Sbjct: 70 LPKRVQKSLFGVNAIQGMDGSAH--IHRKMLFLSLMT--------PPHQKRLAELMTEEW 119 Query: 168 EVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEV 227 + ++ ++ + + V C G + ++F ++ Sbjct: 120 KAAVTRWEKAD----EVVLFEEAKEILCRVACYWA-GVPLKETE-----VKERADDFIDM 169 Query: 228 VGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIE 287 V + P + + +++ M+++ K + Sbjct: 170 VDAFGAV----------GPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMAF 219 Query: 288 HCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEEL 347 H QE + +++ ++IN++ + IS+ L++ + K +E L Sbjct: 220 HTQEDGSQ--LDSRMAAIELINVLRPIVA---------ISYFLVFSALALHEHPKYKEWL 268 Query: 348 DTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCV 407 + R R E F+ E R+ F PF + +D KG V Sbjct: 269 RSGNSRER-------------EMFVQEVRRYYPFGPF-LGALVKKDFVWNNCEFKKGTSV 314 Query: 408 FVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEV 467 ++ + NHD +LW +P EF PERF + + ++ + G +C GE I + Sbjct: 315 LLDLYGTNHDPRLWDHPDEFRPERFAEREENLFDMIPQGGGHAEKG-HRCPGEGITIEVM 373 Query: 468 FLFLAILLQRVEFSVP 483 L L+ ++E+ VP Sbjct: 374 KASLDFLVHQIEYDVP 389 >6FSH-A nrPDB Length = 398 Score = 142 bits (357), Expect = 5e-34, Method: Composition-based stats. Identities = 48/272 (17%), Positives = 92/272 (33%), Gaps = 41/272 (15%) Query: 231 GNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQ 290 G P D + L + L+A L++K + + + +D D I Sbjct: 157 GVPRDDRDMFMKLCHGHLDA--SLSQKRRAALGDKFSRYLLAMIARERKDPGDGFIGSIV 214 Query: 291 EKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTV 350 + D ++DE++ + + L AG D V+ I ++ L+ +P ++ + + Sbjct: 215 AEHGDT-----ITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQS- 268 Query: 351 IGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVN 410 + + E R+ + P + D + I +G V + Sbjct: 269 -----------------ADRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCS 311 Query: 411 QWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLF 470 N D+ L + R + FG G C+G + R ++ + Sbjct: 312 LPMANRDRALLPDADRLDVTR-----------TPVPHVAFGHGIHHCLGAALTRLQLRIA 360 Query: 471 LAILLQRVE---FSVPLGVKV--DMTPIYGLT 497 L +R + P + TP YGLT Sbjct: 361 YTALWRRFPALQLADPAQEIMFRTSTPAYGLT 392 >4YT3-A nrPDB Length = 410 Score = 142 bits (357), Expect = 5e-34, Method: Composition-based stats. Identities = 55/326 (16%), Positives = 113/326 (34%), Gaps = 50/326 (15%) Query: 172 STLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSG 231 +Q + P R ++ + + R EL+ ++ V Sbjct: 84 EKIQITESDPPDHRKRRSLLAAAFTPRSLQNWEPRIQEIADELIGQMDGGTEIDIVASLA 143 Query: 232 NPADFIPILRYLPNPSLNAF--------------KDLNEKFYSFMQKMVKEHYKTFEK-- 275 +P I + + PS + ++ E+ Q KE+Y+ Sbjct: 144 SPLPIIVMADLMGVPSKDRLLFKKWVDTLFLPFDREKQEEVDKLKQVAAKEYYQYLYPIV 203 Query: 276 -GHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 334 + D +I + ++D +D++++ + + GAG +T + ++ S L+ Sbjct: 204 VQKRLNPADDIISDLLKSEVDGEM---FTDDEVVRTTMLILGAGVETTSHLLANSFYSLL 260 Query: 335 -MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRD 393 + V +++ E LD V + E R F + + D Sbjct: 261 YDDKEVYQELHENLDLV------------------PQAVEEMLRFR-FNLIKLDRTVKED 301 Query: 394 TSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMG 453 L G + +G V V N D++++ +P R ++K + FG G Sbjct: 302 NDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHR----------PNNKKHLTFGNG 351 Query: 454 KRKCIGETIARWEVFLFLAILLQRVE 479 C+G +AR E + L L++ + Sbjct: 352 PHFCLGAPLARLEAKIALTAFLKKFK 377 >1F4U-A nrPDB Length = 368 Score = 141 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 70/409 (17%), Positives = 141/409 (34%), Gaps = 48/409 (11%) Query: 109 LYTFTLISNGQSMSFSPDSGPVWAA-RRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEA 167 +Y + + + G +W R + L +FS S + LE+ + + Sbjct: 1 MYDWFSEMRKKDPVY--YDGNIWQVFSYRYTKEVLNNFSKFSSDLTGYHERLEDLRNGKI 58 Query: 168 EVLI-STLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNN-FG 225 I + L + P + R + + + + LL ++ + Sbjct: 59 RFDIPTRYTMLTSDPPLHDELRSMSADIFSPQKLQTLETFIRETTRSLLDSIDPREDDIV 118 Query: 226 EVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSL 285 + + P I + LP FK+ ++ +F E ++ +K ++ + Sbjct: 119 KKLAVPLPIIVISKILGLPIEDKEKFKEWSD-LVAFRLGKPGEIFELGKKYL--ELIGYV 175 Query: 286 IEHCQE--KQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKI 343 +H + + N LSD + + ++ L AG +T T IS S++ + ++I Sbjct: 176 KDHLNSGTEVVSRVVNSNLSDIEKLGYIILLLIAGNETTTNLISNSVIDFTRF-NLWQRI 234 Query: 344 QEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPK 403 +EE I E R+S V T L I + Sbjct: 235 REE-------------------NLYLKAIEEALRYSPPV-MRTVRKTKERVKLGDQTIEE 274 Query: 404 GRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIA 463 G V V N D++++ + +F+P+R P + FG G C+G +A Sbjct: 275 GEYVRVWIASANRDEEVFHDGEKFIPDRNPNP-----------HLSFGSGIHLCLGAPLA 323 Query: 464 RWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS 512 R E + + +R +D + + + ++L+S Sbjct: 324 RLEARIAIEEFSKRFR----HIEILDTEKVPNEVLN--GYKRLVVRLKS 366 >1LG9-A nrPDB Length = 398 Score = 141 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 52/272 (19%), Positives = 93/272 (34%), Gaps = 41/272 (15%) Query: 231 GNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQ 290 G P D + L + L+A L++K + + + ++ + +I Sbjct: 157 GVPRDDRDMFMKLCHGHLDA--SLSQKRRAALGDKFSRYLLAMIARERKEPGEGMIGAVV 214 Query: 291 EKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTV 350 + D+ +DE++ + + AG D ++ I ++ ++ +P E++D Sbjct: 215 AEYGDDA-----TDEELRGFCVQVMLAGDDNISGMIGLGVLAMLRHP-------EQIDAF 262 Query: 351 IGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVN 410 G + + + E R+ + P D +L G I KG V + Sbjct: 263 RGDEQS-----------AQRAVDELIRYLTVPYSPTPRIAREDLTLAGQEIKKGDSVICS 311 Query: 411 QWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLF 470 N D L + R P + FG G C+G +AR E+ Sbjct: 312 LPAANRDPALAPDVDRLDVTREPIP-----------HVAFGHGVHHCLGAALARLELRTV 360 Query: 471 LAILLQRVEFSVPLGVKVD-----MTPIYGLT 497 L +R D TP YGLT Sbjct: 361 FTELWRRFPALRLADPAQDTEFRLTTPAYGLT 392 >3A1L-A nrPDB Length = 425 Score = 140 bits (353), Expect = 1e-33, Method: Composition-based stats. Identities = 51/327 (15%), Positives = 96/327 (29%), Gaps = 46/327 (14%) Query: 165 KEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLV--NLNN 222 + ++ + P H + + I R LL + Sbjct: 88 RALRTVVENWLVFLDPPHHTELRSLLTTEFSPSI-VTGLRPRIAELASALLDRLRAQRRP 146 Query: 223 NFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKE-HYKTFEKGHIRDI 281 + E + P I L +P + ++ + ++ Sbjct: 147 DLVEGFAAPLPILVISALLGIPEEDHTWLRANAVALQEASTTRARDGRGYARAEAASQEF 206 Query: 282 TDSLIEHCQEKQLDE------------NANVQLSDEKIINIVLDLFGAGFDTVTTAISWS 329 T + D+ + LS + I+ + L AG +T T ++ + Sbjct: 207 TRYFRREVDRRGGDDRDDLLTLLVRARDTGSPLSVDGIVGTCVHLLTAGHETTTNFLAKA 266 Query: 330 LMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHS 389 ++ L + V ++ R+ A + E R+ V + Sbjct: 267 VLTLRAHRDVLDEL------------------RTTPESTPAAVEELMRYDPPVQ-AVTRW 307 Query: 390 TTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVII 449 D L IP+G V N D + +P R +E+ + Sbjct: 308 AYEDIRLGDHDIPRGSRVVALLGSANRDPARFPDPDVLDVHR-----------AAERQVG 356 Query: 450 FGMGKRKCIGETIARWEVFLFLAILLQ 476 FG+G C+G T+AR E + L LL Sbjct: 357 FGLGIHYCLGATLARAEAEIGLRALLD 383 >4MM0-A nrPDB Length = 399 Score = 140 bits (353), Expect = 1e-33, Method: Composition-based stats. Identities = 61/400 (15%), Positives = 130/400 (32%), Gaps = 74/400 (18%) Query: 80 STPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQ 139 P +++ + +R L F R DL ++ S PV RRL Sbjct: 44 GDPGFLVTRYEDVRFVLSD--PRFSVRQDLPGAPRLTEMTFESVMTTDPPVHTRLRRL-- 99 Query: 140 NGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVIC 199 ++ D + + + + AE L+ +++ P V +T VIC Sbjct: 100 -------LSRDFTARRIERMRPRLEEIAEGLLDEMEK-KGAPADIVESLAVPFPIT-VIC 150 Query: 200 AICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFY 259 + D V + + + S + Sbjct: 151 ELLGVPMVD---------VARFRGWADTMVSLTGYSMEDW------------TAARDALE 189 Query: 260 SFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGF 319 S++ +V + D+ +L+ E + +L+D + ++ L L AG+ Sbjct: 190 SYLDGLVAAKRENP----GSDLLSALVATAAE-------DNELTDHDVRSLSLILLLAGY 238 Query: 320 DTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHS 379 + + + S++ L+ P +++ + + + + E R++ Sbjct: 239 EPASNQLGSSVLTLLRFPDRLAELRRDPG------------------LLPSAVEELMRYA 280 Query: 380 SFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAI 439 + T D ++ +IP V + N D + + +P+ +R Sbjct: 281 PAGDGALFRVTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTGLRLDR-------- 332 Query: 440 DKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 + G G C+G +AR E+ + + LL+R Sbjct: 333 ---PDNQHTALGHGIHFCLGAALARVELQVAIGALLRRFP 369 >4TX3-A nrPDB Length = 404 Score = 140 bits (353), Expect = 1e-33, Method: Composition-based stats. Identities = 47/272 (17%), Positives = 91/272 (33%), Gaps = 41/272 (15%) Query: 231 GNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQ 290 G P D + L + L+A L+ + + + + +D D I Sbjct: 163 GVPRDDQAMFLQLCHRHLDA--SLSARKRAAAGEAFARYLVAMMARERKDPGDGFIGSIV 220 Query: 291 EKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTV 350 + D ++DE++ + + L AG D V+ I ++ L+ +P ++ + + Sbjct: 221 AEHGDT-----ITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQS- 274 Query: 351 IGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVN 410 + + E R+ + P + D + I +G V + Sbjct: 275 -----------------ADRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCS 317 Query: 411 QWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLF 470 N D+ L + R + FG G C+G + R ++ + Sbjct: 318 LPMANRDRALLPDADRLDVTR-----------TPVPHVAFGHGIHHCLGAALTRLQLRIA 366 Query: 471 LAILLQRVE---FSVPLGVKV--DMTPIYGLT 497 L +R + P + TP YGLT Sbjct: 367 YTALWRRFPALQLADPAQEIMFRTSTPAYGLT 398 >1UED-A nrPDB Length = 406 Score = 140 bits (352), Expect = 2e-33, Method: Composition-based stats. Identities = 68/438 (15%), Positives = 131/438 (29%), Gaps = 83/438 (18%) Query: 58 NPHLALSRMSQQYGDVLQI------RIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYT 111 +PH + +G +++I ++G V G + +R+ L + F RP Sbjct: 25 DPHEDNFGLRA-HGPLVRIVGESSTQLGRDFVWQAHGYEVVRRILGDH-EHFTTRPQFTQ 82 Query: 112 FTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLI 171 ++ ++ S RL + F++ + + LI Sbjct: 83 SKSGAHVEAQFVGQISTYDPPEHTRLRKMLTPEFTVRRI----------RRMEPAIQSLI 132 Query: 172 STLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSG 231 +L+ G + + + +E + + N + Sbjct: 133 DDRLDLLEAEGPSADLQGLFADPVGAHALCELLGIPRDDQREFVRRIRRNADLSR----- 187 Query: 232 NPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQE 291 L A + F ++ ++ D D L+ Sbjct: 188 ---------------GLKARAADSAAFNRYLDNLLARQRA--------DPDDGLLGMIVR 224 Query: 292 KQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVI 351 D ++DE++ + L G +TV I + ++ L+ NP + E + Sbjct: 225 DHGDN-----VTDEELKGLCTALILGGVETVAGMIGFGVLALLDNPGQIELLFESPEK-- 277 Query: 352 GRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQ 411 E + E R+ S V P +D + G I G V + Sbjct: 278 ----------------AERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSI 321 Query: 412 WQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFL 471 N D+ L +P R D + FG G C+G +AR + + Sbjct: 322 LMANRDEALTPDPDVLDANRAAVSD-----------VGFGHGIHYCVGAALARSMLRMAY 370 Query: 472 AILLQRV---EFSVPLGV 486 L +R +VP+ Sbjct: 371 QTLWRRFPGLRLAVPIEE 388 >1ODO-A nrPDB Length = 408 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 71/437 (16%), Positives = 128/437 (29%), Gaps = 80/437 (18%) Query: 71 GDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSF------- 123 G + + +S ++Q L R F + ++ Sbjct: 28 GPATWVDVLGVQAWSVSDPVLLKQLLTSSDVSKDARAHWPAFGEVVGTWPLALWVAVENM 87 Query: 124 SPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGH 183 GP RRL + + +E V+ L+ L EL AG Sbjct: 88 FTAYGPNHRKLRRLVAPAFSA-----RRVDAMRPAVEAMVT----GLVDRLAELPAGE-P 137 Query: 184 FNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVN--LNNNFGEVVGSGNPADFIPILR 241 + + + + + G D +LV+ + + N Sbjct: 138 VDLRQELAYPLPIAVIGHLMGVPQDRRDG-FRALVDGVFDTTLDQAEAQAN--------- 187 Query: 242 YLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQ 301 + Y + +++ T D+T LI + DE + Sbjct: 188 -------------TARLYEVLDQLIAAKRATP----GDDMTSLLIAA----RDDEGDGDR 226 Query: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSD 361 LS E++ + +L + AG++T I ++ L+ P +++ +D Sbjct: 227 LSPEELRDTLLLMISAGYETTVNVIDQAVHTLLTRPDQLALVRK---------GEVTWAD 277 Query: 362 RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSL-KGFYIPKGRCVFVNQWQINHDQKL 420 + ET RH V D +L G I +G + + N Sbjct: 278 ---------VVEETLRHEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDW 328 Query: 421 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 480 + F R + + FG G C+G +AR EV L L L R Sbjct: 329 HEDADTFDATRTVKE-----------HLAFGHGVHFCLGAPLARMEVTLALESLFGRFPD 377 Query: 481 SVPLGVKVDMTPIYGLT 497 ++ P+ L Sbjct: 378 LRLADPAEELPPVPSLI 394 >3MGX-A nrPDB Length = 415 Score = 139 bits (350), Expect = 3e-33, Method: Composition-based stats. Identities = 45/261 (17%), Positives = 92/261 (35%), Gaps = 50/261 (19%) Query: 252 KDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIV 311 + + + + +++ K E G D+ +L+ + L+ + ++ Sbjct: 204 RQAHTEILVYFDELITARRK--EPGD--DLVSTLVT-----------DDDLTIDDVLLNC 248 Query: 312 LDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAF 371 ++ G +T AI+ ++ L P + +++ V + Sbjct: 249 DNVLIGGNETTRHAITGAVHALATVPGLLTALRDGSADV------------------DTV 290 Query: 372 ILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPER 431 + E R +S + TT D ++ G +P G V N D + +P FLP R Sbjct: 291 VEEVLRWTSPAMHVL-RVTTADVTINGRDLPSGTPVVAWLPAANRDPAEFDDPDTFLPGR 349 Query: 432 FLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMT 491 + I FG G C+G +AR E+ + L +L +RV V ++ Sbjct: 350 KPN-----------RHITFGHGMHHCLGSALARIELSVVLRVLAERVS-----RVDLERE 393 Query: 492 PIYGLTMKHACCEHFQMQLRS 512 P + + ++ Sbjct: 394 PAWLRAIVVQGYRELPVRFTG 414 >5HDI-A nrPDB Length = 404 Score = 138 bits (348), Expect = 5e-33, Method: Composition-based stats. Identities = 71/432 (16%), Positives = 139/432 (32%), Gaps = 84/432 (19%) Query: 57 KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFK----------GR 106 ++P+ RM G V +I ++ + G D + +A + + +DF Sbjct: 17 QDPYPLYERMRAA-GSVHRI--ANSDFYAVCGWDAVNEA-IGRPEDFSSNLTATMTYTAE 72 Query: 107 PDLYTFTL-ISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSK 165 F + G + + P A R+L L + I +E+ + Sbjct: 73 GTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIR---------VMEQFTVQ 123 Query: 166 EAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFG 225 A+ L G + + ++ N + + ++ LV Sbjct: 124 AADRLWVD--------GMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGYAAT 175 Query: 226 EVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSL 285 +++ D L A + ++ + D D+L Sbjct: 176 QLLEGLVEND-----------QLVAAGVALMELSGYIFEQFDRAAA--------DPRDNL 216 Query: 286 IEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQE 345 + + L+ + +++ LF AG ++ + ++ L P +Q+++ Sbjct: 217 LGELATACASGELDT-LTAQ---VMMVTLFAAGGESTAALLGSAVWILATRPDIQQQV-- 270 Query: 346 ELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGR 405 R++ + AFI ET R+ H T+L G +P Sbjct: 271 ----------------RANPELLGAFIEETLRYEPPFRGHYRHVRNA-TTLDGTELPADS 313 Query: 406 CVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARW 465 + + N D + P EF +R + I FG G C+G +AR Sbjct: 314 HLLLLWGAANRDPAQFEAPGEFRLDR----------AGGKGHISFGKGAHFCVGAALARL 363 Query: 466 EVFLFLAILLQR 477 E + L +LL R Sbjct: 364 EARIVLRLLLDR 375 >5M0P-A nrPDB Length = 428 Score = 137 bits (346), Expect = 8e-33, Method: Composition-based stats. Identities = 81/450 (18%), Positives = 160/450 (35%), Gaps = 58/450 (12%) Query: 49 IGHMLTLGKNPHLALSRMSQQYG-DVLQIR-IGSTPVVVLSGLDTIRQALVRQGDDFKGR 106 + + L + K +L + + V Q + +G P VV++G + + D + Sbjct: 16 LDNTLKVLKQGYLYTTNQRNRLNTSVFQTKALGGKPFVVVTGKEGAE--MFYNNDVVQRE 73 Query: 107 PDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKE 166 L + + + G R+ L + + ++ +V + Sbjct: 74 GMLPKRIVNTLAGKGAIHTVDGKKHVDRKALFMSLMTEGNL-------------NYVREL 120 Query: 167 AEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGE 226 L + M N YR +V +T V + + + + + +++ + Sbjct: 121 TRTLWHANTQRMESMDEVNIYRESIVLLTKVGTRWAGVQAPPEDIERIATDMDIMIDSFR 180 Query: 227 VVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLI 286 +G A K+ + ++++ + E K H + T Sbjct: 181 ALGGAF-------------KGYKASKEARRRVEDWLEEQIIETRKGNI--HPPEGTALYE 225 Query: 287 EHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEE 346 E L + + ++N L + +S+ L + NP + KI+ E Sbjct: 226 FAHWEDYLGNPMDSRTCAIDLMNTFRPLIA-----INRFVSFGLHAMNENPITREKIKSE 280 Query: 347 LDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRC 406 D Y F E R+ FVPF +P D +G IP G Sbjct: 281 PD------------------YAYKFAQEVRRYYPFVPF-LPGKAKVDIDFQGVTIPAGVG 321 Query: 407 VFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWE 466 + ++ + HD+ LW +P+EF PERF T DG+ ++ + + +C GE I Sbjct: 322 LALDVYGTTHDESLWDDPNEFRPERFETWDGSPFDLIPQGGGDYWTN-HRCAGEWITVII 380 Query: 467 VFLFLAILLQRVEFSVP-LGVKVDMTPIYG 495 + + +++ + VP ++VD+ I G Sbjct: 381 MEETMKYFAEKITYDVPEQDLEVDLNSIPG 410 >2RFC-A nrPDB Length = 343 Score = 137 bits (345), Expect = 1e-32, Method: Composition-based stats. Identities = 47/255 (18%), Positives = 87/255 (34%), Gaps = 48/255 (18%) Query: 233 PADFIPILRYLPNPSLNAFKDLNEKF--------YSFMQKMVKEHYKTFEKGHIRDITDS 284 P + I + +P+ + FK ++ ++++ + K I + Sbjct: 103 PVNIISKILGIPDSDMPLFKLWSDYIIGNKRDENFNYVNNRMVSRLLEIFKSDSHGIINV 162 Query: 285 LIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQ 344 L + N +L+ ++ I ++ L G +T T I + + NP + Sbjct: 163 LAGSSLK-------NRKLTMDEKIKYIMLLIIGGNETTTNLIGNMIRVIDENPDI----- 210 Query: 345 EELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKG 404 +D + F+ ET R+ S + F D+ + I KG Sbjct: 211 --IDDALKNR--------------SGFVEETLRYYSPIQFLPHRFAAEDSYINNKKIKKG 254 Query: 405 RCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIAR 464 V V N D+ + P F R E + FG+G C+G +AR Sbjct: 255 DQVIVYLGSANRDETFFDEPDLFKIGR------------REMHLAFGIGIHMCLGAPLAR 302 Query: 465 WEVFLFLAILLQRVE 479 E + L +L + Sbjct: 303 LEASIALNDILNHFK 317 >5DQN-A nrPDB Length = 426 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 73/424 (17%), Positives = 130/424 (30%), Gaps = 83/424 (19%) Query: 85 VLSGLDTIRQALVRQGDDFKGRPD----LYTFTL---ISNGQSMSFSPDSGPVWAARRRL 137 +++ +++ R+ D F PD +Y + + Q P R++ Sbjct: 55 LVTKHADVKEV-SRRSDVFGSSPDGAIPVYPQDMTREAVDLQRAVLLNMDAPQHTRLRKI 113 Query: 138 AQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNV 197 G +I + E + + A G + V + Sbjct: 114 ISRGFTPRAIG-------------RLEDELRSRAQKIAQTAAAQGAGDFVEQVSCELPLQ 160 Query: 198 ICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEK 257 A G D + + AD P + + Sbjct: 161 AIAELLGVPQDDRDKLFRWSNEMTAG-----EDPEYADVDPAMSSF-------------E 202 Query: 258 FYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGA 317 S+ KM +E DI LIE + +LSD++ V+ L A Sbjct: 203 LISYAMKMAEERAVNP----TEDIVTKLIEA-------DIDGEKLSDDEFGFFVVMLAVA 251 Query: 318 GFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFR 377 G +T +I+ ++ NP ++E R +D E R Sbjct: 252 GNETTRNSITHGMIAFAQNPDQWELYKKE--------RPETAAD------------EIVR 291 Query: 378 HSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG 437 ++ V + D L G I KG+ V ++ N D++++ +P F R P Sbjct: 292 WATPVS-AFQRTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNILRSPNP-- 348 Query: 438 AIDKVLSEKVIIFGM-GKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGL 496 + FG G CIG +AR + L + + P+G + + Sbjct: 349 ---------HVGFGGTGAHYCIGANLARMTINLIFNAIADNMPDLKPIGAPERLKSGWLN 399 Query: 497 TMKH 500 +KH Sbjct: 400 GIKH 403 >3TKT-A nrPDB Length = 450 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 77/420 (18%), Positives = 137/420 (32%), Gaps = 66/420 (15%) Query: 80 STPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS---MSFSPDSGPVWAARRR 136 S V+ + D + F R I+ G S P RR Sbjct: 78 SFDGVMKASKDNATFLNNPKSTVFTLRVGEMMAKAITGGSPHLVESLVQMDAPKHPKLRR 137 Query: 137 LAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSV-- 194 L Q+ ++A L+ + K A I + G G + +V + Sbjct: 138 LTQDWFMPKNLAR---------LDGEIRKIANEAIDRML----GAGEEGDFMALVAAPYP 184 Query: 195 TNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDL 254 +V+ I G + + L + E + D P Sbjct: 185 LHVVMQIL-GVPPEDEPKMLFLTQQMFGGQDEDMNKSGLKDLP------PEQISQIVAGA 237 Query: 255 NEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDL 314 +F + + E R+ TD + +D +SD + Sbjct: 238 VAEFERYFAGLAAERR--------RNPTDDVATVIANAVVD---GEPMSDRDTAGYYIIT 286 Query: 315 FGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILE 374 AG DT + + + + + L +P + +++ +DR+ LP + E Sbjct: 287 ASAGHDTTSASSAGAALALARDPDLFARVK---------------ADRNLLP---GIVEE 328 Query: 375 TFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 434 R ++ V + + DT L G I G + +N NHD + P +F P R Sbjct: 329 AIRWTTPVQHFM-RTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTR--- 384 Query: 435 PDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIY 494 + + + FG G +C+G +AR E+ + L +LL RV+ G + + Sbjct: 385 --------PANRHLAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRVNSTF 436 >6G5O-A nrPDB Length = 399 Score = 136 bits (342), Expect = 2e-32, Method: Composition-based stats. Identities = 43/233 (18%), Positives = 85/233 (36%), Gaps = 41/233 (17%) Query: 250 AFKDLNEKFY----SFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDE 305 F+ E + + + E + D+ L+ E +L+ E Sbjct: 156 VFRSEGEALDGDKANILYHYIDEQIDRASENPGDDMYSVLL-------NSEFEGRKLTKE 208 Query: 306 KIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHL 365 ++ +++ F G DTV A++ S+ YL +P ++++E + Sbjct: 209 EVKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRKEPEI---------------- 252 Query: 366 PYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPS 425 + E R+ S + + T DT + + + + N D ++ NP+ Sbjct: 253 --TGRAVEEMIRYFSPL-TQMGRVVTEDTHVCEHAVKADSRISLCWASANRDAAVFENPN 309 Query: 426 EFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 E + +R + P + FG C+G T AR + + L L Q+V Sbjct: 310 EIVLDRKVNP-----------HVGFGFSHHNCLGATHARQILKILLQTLAQKV 351 >6HQG-A nrPDB Length = 425 Score = 135 bits (339), Expect = 5e-32, Method: Composition-based stats. Identities = 65/393 (16%), Positives = 125/393 (31%), Gaps = 63/393 (16%) Query: 95 ALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASS 154 A+ + F P + + F P +R+ Q + + Sbjct: 74 AVDTNHEVFSSEPTIVLPDPADDFTLPMFIAMDPPKHDVQRKTVQPIVAP---------N 124 Query: 155 TSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQEL 214 YLE + + A ++ L N V + +T + A F + + Sbjct: 125 HLAYLEPIIRERAGKILDDLP----IGEEINWVDKVSIELTTMTLATLFD--FPWEDRRK 178 Query: 215 LSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFE 274 L+ + G D P N + + + ++ E Sbjct: 179 LTFWSDVATSAPESGILGTTD--------PEEHENLRRQTLFECVDYFMRLWNERVNAPP 230 Query: 275 KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 334 K LI + +N + + + ++ L G DT IS S++ L Sbjct: 231 KPD-------LISMLAHGESTKN----MDRMEYLGNLILLIVGGNDTTRNTISGSVLALH 279 Query: 335 MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDT 394 NP RK++E + + A + ET R + + + + RD Sbjct: 280 QNPDQDRKLRE------------------NPGLIPAMVSETIRWQTPLAY-MRRRAKRDF 320 Query: 395 SLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGK 454 L G I +G V + N D+++ P+++ ER + + FG G Sbjct: 321 ELGGKTIREGDKVAMWYVSGNRDEEVIDRPNDYWIER----------PRVRQHLSFGFGV 370 Query: 455 RKCIGETIARWEVFLFLAILLQRVEFSVPLGVK 487 +C+G +A ++ + +L R +G Sbjct: 371 HRCVGNRLAELQLKIIWEEILARFPRLEVVGPP 403 >4TRI-A nrPDB Length = 407 Score = 132 bits (331), Expect = 4e-31, Method: Composition-based stats. Identities = 40/216 (18%), Positives = 79/216 (36%), Gaps = 34/216 (15%) Query: 278 IRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNP 337 + TD L +++ ++SD++I+ L + G +T +S L+ + Sbjct: 197 RAEPTDDLFSVLVNSEVE---GQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHR 253 Query: 338 RVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLK 397 + ++D + I E R +S V + + T DT Sbjct: 254 DQWDALVADVD------------------LLPGAIEEMLRWTSPVK-NMCRTLTADTVFH 294 Query: 398 GFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKC 457 G + G + + N D+ ++ +P F +R + FG G C Sbjct: 295 GTELRAGEKIMLMFESANFDESVFGDPDNFRIDR-----------NPNSHVAFGFGTHFC 343 Query: 458 IGETIARWEVFLFLAILLQRV-EFSVPLGVKVDMTP 492 +G +AR E+ L +L+R+ + + V + P Sbjct: 344 LGNQLARLELRLMTERVLRRLPDLRLADDAPVPLRP 379 >2WM5-A nrPDB Length = 435 Score = 132 bits (331), Expect = 4e-31, Method: Composition-based stats. Identities = 70/414 (16%), Positives = 134/414 (32%), Gaps = 72/414 (17%) Query: 85 VLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPD---SGPVWAARRRLAQNG 141 L+ D + A R D F P++ T + + F P R + Sbjct: 78 ALTKYDDVFYA-SRHPDIFSSYPNI-TINDQTPELAEYFGSMIVLDDPRHQRLRSIVSRA 135 Query: 142 LKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAI 201 +E V A L+S++ +IC + Sbjct: 136 FTP---------KVVARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDM 186 Query: 202 CFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSF 261 + DH Q + N+ FG+ + + +F+ ++ ++ Sbjct: 187 MGIPKADH--QRIFHWTNVILGFGDPDLATDFDEFM---------------QVSADIGAY 229 Query: 262 MQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDT 321 + ++ H D+T SL+E E +LS +I + + L AG +T Sbjct: 230 ATALAEDRRV----NHHDDLTSSLVEA-------EVDGERLSSREIASFFILLVVAGNET 278 Query: 322 VTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSF 381 AI+ ++ L P + + + D + + E R +S Sbjct: 279 TRNAITHGVLALSRYPEQRDRWWSDFDGL-----------------APTAVEEIVRWASP 321 Query: 382 VPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDK 441 V + + + T+D L+G + G V + N D+ + +P F R P Sbjct: 322 VVY-MRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNP------ 374 Query: 442 VLSEKVIIF-GMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIY 494 + F G G C+G +AR E+ + L +++ V + + Sbjct: 375 -----HLGFGGGGAHFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQF 423 >6HQW-A nrPDB Length = 445 Score = 132 bits (331), Expect = 4e-31, Method: Composition-based stats. Identities = 48/301 (15%), Positives = 108/301 (35%), Gaps = 34/301 (11%) Query: 189 YVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSL 248 + +V+ ++ +G R+D + + L + + + L Sbjct: 159 EIRRRTASVLDSLPWGERFDWVDKVSIELTTGMLAILFGFPWADRRLLTFWSDWAGDVEL 218 Query: 249 NAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKII 308 ++L + + F+ +M + + + LI A +S ++ + Sbjct: 219 TLARELADTRFGFLGEMAHYFQRLWGARMQAPPSGDLISMMIH----SEAMNHMSPQEFM 274 Query: 309 NIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYM 368 ++ L G DT +S + L P + ++ D S +P Sbjct: 275 GNLVLLIVGGNDTTRNTMSGIVHALDKFPDQRELLER---------------DASLIP-- 317 Query: 369 EAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFL 428 + E R+ + + + + T DT L G I G V + N D+ ++ NP + + Sbjct: 318 -NAVQECIRYVTPLAH-MRRTATADTELFGNQIKAGEKVILWYISANRDETVFENPDKLM 375 Query: 429 PERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKV 488 +R + + + FG G +C+G +A ++ + L + +R V + +V Sbjct: 376 VDR----------PNARRHLSFGHGIHRCVGARLAELQLRILLEEMHER-RMRVRVAGEV 424 Query: 489 D 489 + Sbjct: 425 E 425 >3RWL-A nrPDB Length = 426 Score = 132 bits (331), Expect = 5e-31, Method: Composition-based stats. Identities = 39/201 (19%), Positives = 76/201 (37%), Gaps = 33/201 (16%) Query: 279 RDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPR 338 +D + LI N ++ E+ + VL L G DT +++ ++ L NP Sbjct: 231 KDPGNDLISMLAHSPATRN----MTPEEYLGNVLLLIVGGNDTTRNSMTGGVLALHKNPD 286 Query: 339 VQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKG 398 K++ ++ +E + E R + + + + D+ L G Sbjct: 287 QFAKLK------------------ANPALVETMVPEIIRWQTPLAH-MRRTAIADSELGG 327 Query: 399 FYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCI 458 I KG V + + N D ++ P EF+ +R + + FG G +C+ Sbjct: 328 KTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDR----------PRPRQHLSFGFGIHRCV 377 Query: 459 GETIARWEVFLFLAILLQRVE 479 G +A ++ + +L R Sbjct: 378 GNRLAEMQLRILWEEILTRFS 398 >2X9P-A nrPDB Length = 404 Score = 131 bits (330), Expect = 5e-31, Method: Composition-based stats. Identities = 48/284 (16%), Positives = 92/284 (32%), Gaps = 42/284 (14%) Query: 233 PADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEK 292 P + + P + + + K+ + + L+EH + + Sbjct: 155 PFALTVLCEVIGVPPQR--RAELTTLLAGIAKLDDREGAVRAQDDLFGYVAGLVEHKRAE 212 Query: 293 QLDE----NANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELD 348 + + +L+++++ ++ + L AG D+V + + ++ L +P + + D Sbjct: 213 PGPDIISRLNDGELTEDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAAALADPD 272 Query: 349 TVIGRSRRPRLSDRSHLPYMEAFILETFR-HSSFVPFTIPHSTTRDTSLKGFYIPKGRCV 407 M + E R + P + D G I G V Sbjct: 273 V------------------MARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLV 314 Query: 408 FVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEV 467 + N D++ + P EF R P + FG G CIG +AR E+ Sbjct: 315 LFDLGLPNFDERAFTGPEEFDAARTPNP-----------HLTFGHGIWHCIGAPLARLEL 363 Query: 468 FLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLR 511 L R+ P P+ L +K +LR Sbjct: 364 RTMFTKLFTRLPELRP------ELPVEQLRLKEGQLSGGFAELR 401 >6DCD-A nrPDB Length = 424 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 43/213 (20%), Positives = 82/213 (38%), Gaps = 31/213 (14%) Query: 266 VKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTA 325 + + + + + R + ++ + + ++ D ++ LF AG +T Sbjct: 203 LDDKFSAYIEDRRRQPRNDVLTALATATYPDGSTPEVID--VVRSATFLFAAGQETTAKL 260 Query: 326 ISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFT 385 ++ ++ L P +QR+++E +RS +P FI E+ R S V Sbjct: 261 LTAAMRVLGDRPDIQRRLRE---------------NRSLIP---NFIEESLRMDSPVKSD 302 Query: 386 IPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSE 445 + T++ G I G V V N D + + +P EF +R Sbjct: 303 -SRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDR----------PNVR 351 Query: 446 KVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 + + F G C G +AR E + L +L R+ Sbjct: 352 EHMAFARGVHSCPGGPLARVEGRVSLERILDRM 384 >6M7L-A nrPDB Length = 404 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 46/293 (15%), Positives = 91/293 (31%), Gaps = 58/293 (19%) Query: 205 RRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPI------------LRYLPNPSLNAFK 252 RR + ++V+ ++ + +G P +F+ +P Sbjct: 122 RRMQALEPRVQAIVD--DHLDTMASTGPPVEFLREVAGPMAARVACEFLGIPLDDRGELI 179 Query: 253 DLNEKFYSFMQKMVKEHY-----KTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKI 307 L ++++ H + RD D ++ +SDE++ Sbjct: 180 RLTAHRGGKRRRVLNGHAYLAYMRELAARLRRDPGDGMLGMVARDH-----GADISDEEL 234 Query: 308 INIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPY 367 + + + + + ++ + L+ +P ++E Sbjct: 235 AGLCAVVMNSSVEQTESCLAAGTLLLLEHPEQFALLRE------------------RPEL 276 Query: 368 MEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINH-DQKLWVNPSE 426 E + E R+ S P + T D + G I KG VF + N D L Sbjct: 277 GEQAVEEIVRYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAANRADPAL----DG 332 Query: 427 FLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 F R + + FG G C+G +AR E+ + L+ R Sbjct: 333 FDITRKE-----------SRHVAFGHGIHHCLGAPLARMELRIAFTTLVSRFP 374 >1Q5D-A nrPDB Length = 419 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 64/406 (15%), Positives = 116/406 (28%), Gaps = 58/406 (14%) Query: 130 VWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRY 189 W R S E S E I L ++ P Sbjct: 43 YWDEGRSWVLTRYHDVSAVFRDERFAVSREEWESSAEYSSAIPELSDMKKYGLFGLPPED 102 Query: 190 ------VVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNF--GEVVGSGNPADFIPILR 241 +V +LL + F G P I L Sbjct: 103 HARVRKLVNPSFTSRAIDLLRAEIQRTVDQLLDARSGQEEFDVVRDYAEGIPMRAISALL 162 Query: 242 YLPNPSLNAFKDLNEKFYSFMQ----KMVKEHYKTFEKGHIR--DITDSLIEHCQEKQLD 295 +P F+ + V E KT + +++ + L+ Sbjct: 163 KVPAECDEKFRRFGSATARALGVGLVPRVDEETKTLVASVTEGLALLHGVLDERRRNPLE 222 Query: 296 ----------ENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQE 345 E +LS ++++ +V + AG DT I+++++ L+ +P ++ Sbjct: 223 NDVLTMLLQAEADGSRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKA 282 Query: 346 ELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGR 405 E M + E R + + +D G I KG Sbjct: 283 EPG------------------LMRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGE 324 Query: 406 CVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARW 465 VF+ D ++ P F R + + +G G C G ++AR Sbjct: 325 MVFLLIPSALRDGTVFSRPDVFDVRR-----------DTSASLAYGRGPHVCPGVSLARL 373 Query: 466 EVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLR 511 E + + + +R +K+ TP++G E + L+ Sbjct: 374 EAEIAVGTIFRRF-----PEMKLKETPVFGYHPAFRNIESLNVILK 414 >6CVC-A nrPDB Length = 433 Score = 129 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 78/487 (16%), Positives = 154/487 (31%), Gaps = 87/487 (17%) Query: 33 VPKGLKNPPGPWGWPL----IGHMLTLGKNPHL---ALSRMSQQYGDVL--QIRIGSTPV 83 +P+ PP PL +G + G++ A + + ++ I + Sbjct: 12 LPRVNGTPP--PEVPLADIELGSLEFWGRDDDFRDGAFATLRREAPISFWPPIELAGLTA 69 Query: 84 ----VVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPD---SGPVWAARRR 136 L+ D I A R + F P++ + + F P R Sbjct: 70 GKGHWALTKHDDIHFA-SRHPEIFHSSPNIVIHD-QTPELAEYFGSMIVLDDPRHQRLRS 127 Query: 137 LAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTN 196 + +E V + A L++ + E Sbjct: 128 IVSRAFTP---------KVVARIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQ 178 Query: 197 VICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNE 256 +IC + + +H+++ N+ FG+ + + +F+ ++ Sbjct: 179 IICDMM--GIPEEDHEQIFHWTNVILGFGDPDLTTDFDEFL---------------QVSM 221 Query: 257 KFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFG 316 + + + H D+T SL+E E +LS +I + L Sbjct: 222 AIGGYATALADDRRV----NHHGDLTTSLVEA-------EVDGERLSSSEIAMFFILLVV 270 Query: 317 AGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETF 376 AG +T AIS ++ L P + K + D + + E Sbjct: 271 AGNETTRNAISHGMLALSRYPDERAKWWSDFDGLAA-----------------TAVEEIV 313 Query: 377 RHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPD 436 R +S V + + + ++D L+G + G V + N D++ + +P F R P Sbjct: 314 RWASPVVY-MRRTLSQDVDLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQ 372 Query: 437 GAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDM--TPIY 494 G G C+G +AR E+ + L +++ V + I+ Sbjct: 373 VGFG----------GGGAHFCLGANLARREIRVVFDELRRQMPDVVATEEPARLLSQFIH 422 Query: 495 GLTMKHA 501 G+ Sbjct: 423 GIKRLPV 429 >1UE8-A nrPDB Length = 367 Score = 129 bits (323), Expect = 4e-30, Method: Composition-based stats. Identities = 48/270 (17%), Positives = 86/270 (31%), Gaps = 38/270 (14%) Query: 217 LVNLNNNFGEVVGSGNPADFIPILRYLP-NPSLNAFKDLNEKFYSFMQKMVK----EHYK 271 L L+ F + P + I + L NP + KD ++ + + + Sbjct: 105 LSELDEEFDVIESFAIPLPILVISKMLGINPDVKKVKDWSDLVALRLGRADEIFSIGRKY 164 Query: 272 TFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLM 331 + DS + AN LS+ + + L AG +T T I ++ Sbjct: 165 LELISFSKKELDSRKGKEIVDLTGKIANSNLSELEKEGYFILLMIAGNETTTNLIGNAIE 224 Query: 332 YLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTT 391 + ++E + E R S V T Sbjct: 225 DFTLY-NSWDYVRE--------------------KGALKAVEEALRFSPPV-MRTIRVTK 262 Query: 392 RDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFG 451 ++ I +G V V N D++++ +P F+P+R P + FG Sbjct: 263 EKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSFIPDRTPNP-----------HLSFG 311 Query: 452 MGKRKCIGETIARWEVFLFLAILLQRVEFS 481 G C+G +AR E + L ++ Sbjct: 312 SGIHLCLGAPLARLEARIALEEFAKKFRVK 341 >5FYF-A nrPDB Length = 470 Score = 129 bits (323), Expect = 4e-30, Method: Composition-based stats. Identities = 58/379 (15%), Positives = 118/379 (31%), Gaps = 60/379 (15%) Query: 101 DDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLE 160 D F P + F P +R Q + ++ +E Sbjct: 122 DLFSAEPQIILGDPPEGLSVEMFIAMDPPKHDVQRSSVQGVVAPKNLKE---------ME 172 Query: 161 EHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNL 220 + ++ +L + V +V+ + D ++E LV Sbjct: 173 GLIRSRTGDVLDSL--------PTDKPFNWVPAVSKELTGRMLATLLDFPYEERHKLVEW 224 Query: 221 NNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRD 280 ++ S +F + + D+ F + E G D Sbjct: 225 SDRMA-GAASATGGEFADENAMFDDAA-----DMARSFSRLWRDKEARRAAGEEPGF--D 276 Query: 281 ITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQ 340 + L + + K L + I + L G DT ++S L+ + PR Sbjct: 277 LISLLQSNKETKDLINRP------MEFIGNLTLLIVGGNDTTRNSMSGGLVAMNEFPREF 330 Query: 341 RKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFY 400 K++ + + + E R + + + + +D L G Sbjct: 331 EKLK------------------AKPELIPNMVSEIIRWQTPLAY-MRRIAKQDVELGGQT 371 Query: 401 IPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGE 460 I KG V + N D++ + NP +F+ +R + + FG G +C+G Sbjct: 372 IKKGDRVVMWYASGNRDERKFDNPDQFIIDRKDARN----------HMSFGYGVHRCMGN 421 Query: 461 TIARWEVFLFLAILLQRVE 479 +A ++ + +L+R + Sbjct: 422 RLAELQLRILWEEILKRFD 440 >3OFT-A nrPDB Length = 396 Score = 128 bits (321), Expect = 7e-30, Method: Composition-based stats. Identities = 54/278 (19%), Positives = 89/278 (32%), Gaps = 41/278 (14%) Query: 223 NFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDIT 282 +F P + L +P + L + M E K ++ Sbjct: 135 DFVSDFAEILPLNIFLTLIDVPLEDRPRLRQLGVQLTRPDGSMTVEQLKQAADDYLWPFI 194 Query: 283 --------DSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 334 D L + + + ++ + +L G DTV I ++L Sbjct: 195 EKRMAQPGDDLFSRILSEPV---GGRPWTVDEARRMCRNLLFGGLDTVAAMIGMVALHLA 251 Query: 335 MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDT 394 +P QR ++E D + A E R V + + D Sbjct: 252 RHPEDQRLLRERPD------------------LIPAAADELMRRYPTV--AVSRNAVADV 291 Query: 395 SLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGK 454 G I KG V++ N D + P E +R L P + G+G Sbjct: 292 DADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGLAP---------IRHTTMGVGA 342 Query: 455 RKCIGETIARWEVFLFLAILLQRV-EFSVPLGVKVDMT 491 +C+G +AR EV +FL L + EF++ V M Sbjct: 343 HRCVGAGLARMEVIVFLREWLGGMPEFALAPDKAVTMK 380 >3IVY-A nrPDB Length = 433 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 49/250 (19%), Positives = 89/250 (35%), Gaps = 44/250 (17%) Query: 252 KDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIV 311 K + + + KM +E K + D ++ + +D +LSD++ V Sbjct: 214 KASSAELIGYAMKMAEEKAK--------NPADDIVTQLIQADID---GEKLSDDEFGFFV 262 Query: 312 LDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAF 371 + L AG +T +I+ +M +P ++ R +D Sbjct: 263 VMLAVAGNETTRNSITQGMMAFAEHPDQWELYKK--------VRPETAAD---------- 304 Query: 372 ILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPER 431 E R ++ V + RD L G I KG+ V + N D++++ +P F R Sbjct: 305 --EIVRWATPV-TAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILR 361 Query: 432 FLTPDGAIDKVLSEKVIIFGM-GKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDM 490 P + FG G CIG +AR + L + + P+ + Sbjct: 362 NPNP-----------HVGFGGTGAHYCIGANLARMTINLIFNAVADHMPDLKPISAPERL 410 Query: 491 TPIYGLTMKH 500 + +KH Sbjct: 411 RSGWLNGIKH 420 >2XKR-A nrPDB Length = 398 Score = 126 bits (316), Expect = 3e-29, Method: Composition-based stats. Identities = 46/272 (16%), Positives = 91/272 (33%), Gaps = 48/272 (17%) Query: 223 NFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEH------------- 269 +F + + P I + + + F ++ +F+ V + Sbjct: 124 DFVRDLAAPLPMAVIGDMLGVRPEQRDMFLRWSDDLVTFLSSHVSQEDFQITMDAFAAYN 183 Query: 270 --YKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAIS 327 + D TD L+ ++D +LSD++++ L + G +T +S Sbjct: 184 DFTRATIAARRADPTDDLVSVLVSSEVD---GERLSDDELVMETLLILIGGDETTRHTLS 240 Query: 328 WSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIP 387 L+ N +Q + + I E R ++ V + Sbjct: 241 GGTEQLLRNRDQWDLLQRDPS------------------LLPGAIEEMLRWTAPVK-NMC 281 Query: 388 HSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKV 447 T DT G + G + + N D+ ++ P +F +R Sbjct: 282 RVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQR-----------NPNSH 330 Query: 448 IIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 + FG G C+G +AR E+ L +L+R+ Sbjct: 331 LAFGFGTHFCLGNQLARLELSLMTERVLRRLP 362 >6GII-A nrPDB Length = 479 Score = 124 bits (312), Expect = 7e-29, Method: Composition-based stats. Identities = 73/439 (16%), Positives = 155/439 (35%), Gaps = 80/439 (18%) Query: 63 LSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLIS------ 116 R +++ + V++ DTI+Q R F L +F S Sbjct: 83 FVRWAREQVPIF--YAPKLNYWVVTRYDTIKQIF-RDPVTFSPSNVLQSFAQPSAEVRQV 139 Query: 117 -NGQSMSFS----PDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLI 171 +F+ + P+ RRR+ ++ F AS+ + + E V + I Sbjct: 140 LERYGYAFNRTLVNEDEPMHLERRRVL---MEPF--ASEHLAEHEPMVRELVRRAVNRFI 194 Query: 172 STLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSG 231 T G + ++ V + G D + +E + + + Sbjct: 195 DT--------GRADLVDQMIWEVPFTVALHFLG--VDDDDREKMRRFAIAHTVN------ 238 Query: 232 NPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQE 291 R P L + + + F+ F +++++ +T + + ++ Sbjct: 239 ------AFGRPSPEEQLAVAETVGQ-FWQFCGEVLEKMRRTADGPGW------MRYSIRQ 285 Query: 292 KQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVI 351 ++L + ++D + +++ + A +T A + +L L+ + V R+I Sbjct: 286 QKLYPDV---VTDSYLHSMMQAIIVAAHETTVFATTNALKTLLEHETVWREI-------- 334 Query: 352 GRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQ 411 +D S +P A E R++ V TTR+ ++G +P G + + Sbjct: 335 -------CADPSLIP---AAAEECLRYNGPVA-GWRRRTTREVEVEGVRLPVGANILMVV 383 Query: 412 WQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFL 471 NHD + +P F R + + + FG G +C+G + R E+ + + Sbjct: 384 ASANHDSAHFDDPEFFDIGR----------SNASEHLNFGYGAHQCLGRNLGRMEMQIMI 433 Query: 472 AILLQRVEFSVPLGVKVDM 490 L +R+ + D Sbjct: 434 EELSRRLPHMRLAEQRFDY 452 >2IJ7-A nrPDB Length = 396 Score = 124 bits (311), Expect = 9e-29, Method: Composition-based stats. Identities = 43/213 (20%), Positives = 79/213 (37%), Gaps = 32/213 (15%) Query: 279 RDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPR 338 +IT L+ + D A +SDE I + FGAG + + ++ +L+ L+ P+ Sbjct: 196 PNITTGLMGELSRLRKDP-AYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQ 254 Query: 339 VQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKG 398 ++ + E + A + E R + +P T D + Sbjct: 255 LRNLLHE------------------KPELIPAGVEELLRINLSFADGLPRLATADIQVGD 296 Query: 399 FYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCI 458 + KG V V N D + + NP +R + FG G+ C Sbjct: 297 VLVRKGELVLVLLEGANFDPEHFPNPGSIELDR----------PNPTSHLAFGRGQHFCP 346 Query: 459 GETIARWEVFLFLAILLQRV---EFSVPLGVKV 488 G + R + + LL+++ + +VP+ V Sbjct: 347 GSALGRRHAQIGIEALLKKMPGVDLAVPIDQLV 379 >5DE9-A nrPDB Length = 410 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 61/371 (16%), Positives = 113/371 (30%), Gaps = 56/371 (15%) Query: 147 IASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRR 206 + +DP ++ V++ L + G +P + + + A R Sbjct: 63 VTNDPRFGREAVMDRQVTR----LAPHFRPARGAVGFLDPPDHTRLR--RSVAAAFTARG 116 Query: 207 YDHNHQELLSLVNLNNNFGEVVGSGNPADFI-PILRYLPN---------PSLNAFKDL-- 254 + + + L+ ++ +G PAD +L P P+ + Sbjct: 117 VERVRERSRGM--LDELVDAMLRAGPPADLTEAVLSPFPIAVICELMGVPATDRHSMHTW 174 Query: 255 -NEKFYSFMQKMVKEHYKTFEKGHIRDIT----DSLIEHCQEKQLDENANVQLSDEKIIN 309 S V E K + D+ DS E +++ + + Sbjct: 175 TQLILSSSHGAEVSERAKNEMNAYFSDLIGLRSDSAGEDVTSLLGAAVGRDEITLSEAVG 234 Query: 310 IVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYME 369 + + L G + VT L+ P + +++ E + Sbjct: 235 LAVLLQIGG-EAVTNNSGQMFHLLLSRPELAERLRSEPEIR------------------P 275 Query: 370 AFILETFRHSSFV-PFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFL 428 I E R + D +KG I G V+V+ N D +++ +P Sbjct: 276 RAIDELLRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRID 335 Query: 429 PERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKV 488 ER P + FG G C G +AR E L + +L RV Sbjct: 336 FERSPNP-----------HVSFGFGPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPE 384 Query: 489 DMTPIYGLTMK 499 D+ G ++ Sbjct: 385 DVPFKKGALIR 395 >5LIV-A nrPDB Length = 450 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 64/388 (16%), Positives = 123/388 (31%), Gaps = 70/388 (18%) Query: 95 ALVRQGDDFKGRPDLYTFTLISNGQSMS---FSPDSGPVWAARRRLAQNGLKSFSIASDP 151 L+R+ D TF+ + + G A RR+ Sbjct: 92 ILLRKSHITTAYRDTATFSTRMFQAGILNGGLAAMQGDEHARMRRVYNMFFLP------- 144 Query: 152 ASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNH 211 + S Y E V +E ++ L AG + + + + FG + H Sbjct: 145 -RAVSQYEERFVRPISEQVVDRL----AGKPRVDLLEDFAMELPRRVIGELFGFPAEKLH 199 Query: 212 QELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYK 271 + + + + P + + E + ++V+ Sbjct: 200 ETDERVRAMLRGLVRMHD--------------PAAVAESQRAYGETL-GLITEVVER--- 241 Query: 272 TFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLM 331 RD +D+L+ E+ + + E IVL L G++T + ++ ++ Sbjct: 242 -----ESRDTSDTLLGEILRTLKAEHMD---TIEASRQIVLSLILGGYETTSWLVANTIH 293 Query: 332 YLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTT 391 L+ +P +++++ + A I E R F + Sbjct: 294 ALLAHPDTLARVRQDPS------------------LLPAAIEEGMRWCP-SSFGVLRMVE 334 Query: 392 RDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFG 451 RD L + G V + N+D+ + +P + +R P + FG Sbjct: 335 RDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDRKPLPAANV----------FG 384 Query: 452 MGKRKCIGETIARWEVFLFLAILLQRVE 479 G C+G +AR E + L LL R Sbjct: 385 GGAHFCVGAPLARMEARVGLQALLARFP 412 >6F88-A nrPDB Length = 400 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 64/388 (16%), Positives = 123/388 (31%), Gaps = 70/388 (18%) Query: 95 ALVRQGDDFKGRPDLYTFTLISNGQSMS---FSPDSGPVWAARRRLAQNGLKSFSIASDP 151 L+R+ D TF+ + + G A RR+ Sbjct: 42 ILLRKSHITTAYRDTATFSTRMFQAGILNGGLAAMQGDEHARMRRVYNMFFLP------- 94 Query: 152 ASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNH 211 + S Y E V +E ++ L AG + + + + FG + H Sbjct: 95 -RAVSQYEERFVRPISEQVVDRL----AGKPRVDLLEDFAMELPRRVIGELFGFPAEKLH 149 Query: 212 QELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYK 271 + + + + P + + E + ++V+ Sbjct: 150 ETDERVRAMLRGLVRMHD--------------PAAVAESQRAYGETL-GLITEVVER--- 191 Query: 272 TFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLM 331 RD +D+L+ E+ + + E IVL L G++T + ++ ++ Sbjct: 192 -----ESRDTSDTLLGEILRTLKAEHMD---TIEASRQIVLSLILGGYETTSWLVANTIH 243 Query: 332 YLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTT 391 L+ +P +++++ + A I E R F + Sbjct: 244 ALLAHPDTLARVRQDPS------------------LLPAAIEEGMRWCP-SNFGVLRMVE 284 Query: 392 RDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFG 451 RD L + G V + N+D+ + +P + +R P + FG Sbjct: 285 RDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDRKPLPAANV----------FG 334 Query: 452 MGKRKCIGETIARWEVFLFLAILLQRVE 479 G C+G +AR E + L LL R Sbjct: 335 GGAHFCVGAPLARMEARVGLQALLARFP 362 >1WIY-A nrPDB Length = 389 Score = 121 bits (304), Expect = 6e-28, Method: Composition-based stats. Identities = 66/443 (14%), Positives = 133/443 (30%), Gaps = 85/443 (19%) Query: 46 WPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKG 105 WP + L ++P L + + + + + P+ ++ + + AL+ +G Sbjct: 10 WPYL---KDLQQDPLAVLLEWGRAHPRLF-LPLPRFPLALIFDPEGVEGALLAEGTTKA- 64 Query: 106 RPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSK 165 + + +S D G W R+ ++ +E Sbjct: 65 ---TFQYRALSRLTGRGLLTDWGKSWKEARKALKDPFLP-----KSVRGYREAME----- 111 Query: 166 EAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFG 225 E + E + ++ ++ FG+ Sbjct: 112 --EEAWAFFGEWRGEERDLD--HEMLALSLRLLGRALFGK-------------------- 147 Query: 226 EVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSL 285 P+ L +L A + + S + + F K Sbjct: 148 ------------PLSPSLAEHALKALDRIMAQTRSPLALLDLAAEARFRKDR------GA 189 Query: 286 IEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQE 345 + E + L E+ ++ + L AG +TV +A++WS + L P Q+++ E Sbjct: 190 LYREAEALIVHPPLSHLPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRVAE 249 Query: 346 ELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGR 405 + + E R + + R L +P+G Sbjct: 250 SEEAALAAF------------------QEALRLYPPA-WILTRRLERPLLLGEDRLPQGT 290 Query: 406 CVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARW 465 + ++ + + F PERFL G S + FG+G+R C+G A Sbjct: 291 TLVLSPYVTQR--LYFPEGEAFQPERFLAERGT----PSGRYFPFGLGQRLCLGRDFALL 344 Query: 466 EVFLFLAILLQRVEFSVPLGVKV 488 E + L +R +V Sbjct: 345 EGPIVLRAFFRRFRLDPLPFPRV 367 >5L1U-A nrPDB Length = 401 Score = 121 bits (303), Expect = 9e-28, Method: Composition-based stats. Identities = 66/424 (15%), Positives = 123/424 (29%), Gaps = 80/424 (18%) Query: 68 QQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDS 127 Q+ G + ++ +++ D +R L + + + ++ + Sbjct: 28 QKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKSAARAFMVALAAGD 87 Query: 128 GPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPY 187 R L ++ +E HV + L +L A + + Sbjct: 88 DHETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDE-------LLDQLAASAPPVDLH 140 Query: 188 RYV-VVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRY-LPN 245 R + T V+C + V + F R Sbjct: 141 RVLSFRLPTMVVCDLL------------------------GVPLADRERFGQWARGTFDQ 176 Query: 246 PSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDE 305 + ++ +M ++V DI LI + LSD Sbjct: 177 SDNEHSANTFQQVVDYMLELVARKRVEP----GDDILSELIAE---------KDGALSDA 223 Query: 306 KIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHL 365 I ++ + G++T I + L+ NP + ++ E+ Sbjct: 224 DIAHLGNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAEDPG----------------- 266 Query: 366 PYMEAFILETFRHS---SFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWV 422 A + E R IP D ++ I G V + N+D + + Sbjct: 267 -LAPAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFP 325 Query: 423 NPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR---VE 479 + F R V + FG G R CIG T+AR E+ L +R + Sbjct: 326 DGGLFDLTR----------VRPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLR 375 Query: 480 FSVP 483 +VP Sbjct: 376 LAVP 379 >3AWQ-A nrPDB Length = 415 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 67/439 (15%), Positives = 135/439 (30%), Gaps = 67/439 (15%) Query: 51 HMLTLGKNPHLALSRMSQQYG-DVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDL 109 L+L +P+ +SR Q+ G + + R L G + + Sbjct: 12 ETLSLLADPYRFISRQCQRLGANAFESRFLLKKTNCLKGAKAA-EIFYDTTRFEREGAMP 70 Query: 110 YTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEV 169 GQ D G R+++ + E V A++ Sbjct: 71 VAIQKTLFGQGGVQGLD-GETHRHRKQMFMGLMTP----------------ERVRALAQL 113 Query: 170 LISTLQELMAG---PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGE 226 + + + G G Y + +T +CA E + + Sbjct: 114 FEAEWRRAVPGWTRKGEIVFYDELHEPLTRAVCAW---AGVPLPDDEAGNRAGELRALFD 170 Query: 227 VVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLI 286 GS +P + + ++ +++++ T + Sbjct: 171 AAGSASPRHLWS-------------RLARRRVDAWAKRIIEGIRAGSIGSGSG--TAAYA 215 Query: 287 EHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEE 346 + D+ + ++ +++N++ P V + Sbjct: 216 IAWHRDRHDDLLSPHVAAVELVNVL------------------------RPTVAIAVYIT 251 Query: 347 -LDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGR 405 + + R + Y E F+ E R F P + ++D +G P+GR Sbjct: 252 FVAHALQTCSGIRAALVQQPDYAELFVQEVRRFYPFFPAVVAR-ASQDFEWEGMAFPEGR 310 Query: 406 CVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARW 465 V ++ + NHD W +P EF PERF D + + +G +C GE I Sbjct: 311 QVVLDLYGSNHDAATWADPQEFRPERFRAWDEDSFNFIPQGGGDHYLG-HRCPGEWIVLA 369 Query: 466 EVFLFLAILLQRVEFSVPL 484 + + +L+ + + VP Sbjct: 370 IMKVAAHLLVNAMRYDVPD 388 >5H1Z-A nrPDB Length = 407 Score = 118 bits (296), Expect = 5e-27, Method: Composition-based stats. Identities = 45/292 (15%), Positives = 96/292 (32%), Gaps = 50/292 (17%) Query: 203 FGRRYDHNHQELLSLVNLNNNF--GEVVGSGNPADFIPILRYLPNPSLNAFKDLNE---- 256 E+L + N F + V + IL P ++ Sbjct: 118 MSDNIRMRTAEVLDSLEWNTPFDWVDTVSVELTTQMLAILFDFPWEERRKLTFWSDWAGD 177 Query: 257 ----KFYSFMQKMVKEHYK-------TFEKGHIRDITDSLIEHCQEKQLDENANVQLSDE 305 K + ++ Y+ + + T LI +A ++ Sbjct: 178 IELVKNEELRLERLRHMYECGGYFQNLWNAKIGKPPTPDLISMMIH----SDAMAEMDQM 233 Query: 306 KIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHL 365 + + ++ L G DT +S L + P + K++ +D S + Sbjct: 234 EFLGNLILLIVGGNDTTRNTMSAVAYGLDLFPDQRAKLE---------------ADPSMI 278 Query: 366 PYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPS 425 P + E R + + + + T D+ L+G I G + + N D+ ++ N Sbjct: 279 P---NTVQEIIRWQTPLAH-MRRTATVDSELEGQQIKAGDKLALWYISANRDESVFENAD 334 Query: 426 EFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 477 + +R + + + FG G +C+G +A ++ + L + +R Sbjct: 335 RIIVDR----------PNARRHLAFGHGIHRCVGARLAELQIAVLLEEMAKR 376 >5HH3-A nrPDB Length = 397 Score = 118 bits (296), Expect = 6e-27, Method: Composition-based stats. Identities = 72/402 (17%), Positives = 114/402 (28%), Gaps = 82/402 (20%) Query: 79 GSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLA 138 G + +G D IRQ L DDF R LY T + P RR+ Sbjct: 50 GGRTAWLATGYDEIRQVLSS--DDFSAR-LLYGGTAAGITWPGFLTQYDPPEHTRLRRMV 106 Query: 139 QNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVI 198 +++ + V+ +L + A G + SV Sbjct: 107 APAFA------------VRRMQKFQPQVERVVQDSLDAIEALGGPVDFVPRFGWSVATTA 154 Query: 199 CAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKF 258 G D SL S KF Sbjct: 155 TCDFLGIPRDDQADLARSLHASRTER----------------------SGKRRTAAGNKF 192 Query: 259 YSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAG 318 ++M KM RD D + + DE ++D ++ + + GAG Sbjct: 193 MTYMNKMTARTR--------RDPGDDMFGVVVREYGDE-----ITDAELTGVAAFVMGAG 239 Query: 319 FDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRH 378 D V ++ + +P ++E+ DTV P D E R+ Sbjct: 240 ADQVARFLAAGAWLMADDPEQFALLREKPDTV------PDWLD------------EVIRY 281 Query: 379 SSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNP-SEFLPERFLTPDG 437 + T P T D + I G V + N + + P F R Sbjct: 282 LTTDEKTHPRVATDDVRIGDHLIKAGDTVTCSLLAANR--RNFPRPEDRFDITR------ 333 Query: 438 AIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 + + + FG G C+G ++A + L R Sbjct: 334 -----VRPEHLAFGHGIHHCLGRSLAELVFRTAIPALAHRFP 370 >5YHJ-A nrPDB Length = 413 Score = 118 bits (295), Expect = 7e-27, Method: Composition-based stats. Identities = 59/447 (13%), Positives = 138/447 (30%), Gaps = 82/447 (18%) Query: 49 IGHMLTLGKNPHLALSRMSQQY-GDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRP 107 + H + + +L ++ + + ++ + R+ V+ L G + + + Sbjct: 11 LDHSVDFLREGYLFVANRRKSFQSNIFESRLLGERVICLGGEEAA-EVFYDANKFTRQDA 69 Query: 108 DLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGL------KSFSIASDPASSTSCYLEE 161 G+ G R+++ + + + + + EE Sbjct: 70 APKRLLKTLFGEGGV-QTLDGSEHTHRKQMFMSLMTKENIDRLLRLTYREWNQIERMGEE 128 Query: 162 HV--SKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVN 219 V EVL+ + E P + G+R + S + Sbjct: 129 IVLYDIAQEVLMKAVCEWSGVP----------------LAKEEVGKRTEEMRLLFESGTS 172 Query: 220 LNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIR 279 L + + + ++++MVKE Sbjct: 173 LGPTYLQG------------------------RKARSSAEVWIRQMVKEVRSNR------ 202 Query: 280 DITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRV 339 + + E + + +L E+++ + + ++ + ++++ L P V Sbjct: 203 -LLPNEHTALYEFSWHRDESGELLPEEVVAVEVLNILRPTVAISVYVLFTVLALHQFPDV 261 Query: 340 QRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGF 399 + ++ +R + E F+ E R F P T D G+ Sbjct: 262 KEQV-----------------ERGEVSKTE-FVQEVRRFYPFFPVAAARVKT-DFEWDGY 302 Query: 400 YIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKV--IIFGMGKRKC 457 P+G ++ + NHD +W P F P RF + + + + FG +C Sbjct: 303 AFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSRFKDWKESPFNFIPQGGGDVDFG---HRC 359 Query: 458 IGETIARWEVFLFLAILLQRVEFSVPL 484 GE + + + + + ++VP Sbjct: 360 AGEHVTIAILAQVIELFTKEYAYTVPP 386 >3OO3-A nrPDB Length = 384 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 50/313 (15%), Positives = 98/313 (31%), Gaps = 63/313 (20%) Query: 204 GRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKF--YSF 261 RR + + +V + G P DF+ + P P+ A + L + Sbjct: 100 ARRMERLRPRIEEIVE--ECLDDFESVGAPVDFVRHAAW-PIPAYIACEFLGVPRDDQAE 156 Query: 262 MQKMVKEHYKTFEK-------------------GHIRDITDSLIEHCQEKQLDENANVQL 302 + +M++E ++ G RD D +I + ++ Sbjct: 157 LSRMIRESRESRLPRQRTLSGLGIVNYTKRLTSGKRRDPGDGMIGVIVREH-----GAEI 211 Query: 303 SDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDR 362 SDE++ + + + ++ +++ LV +P ++E Sbjct: 212 SDEELAGLAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLRE----------------- 254 Query: 363 SHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWV 422 +++ E RH+S V P D + G I G + + N Sbjct: 255 -KPELIDSATEEVLRHASIVEAPAPRVALADVRMAGRDIHAGDVLTCSMLATNRAPG--- 310 Query: 423 NPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSV 482 F R + FG G CIG +AR ++ + L ++ R Sbjct: 311 --DRFDITR-----------EKATHMAFGHGIHHCIGAPLARLQLRVALPAVVGRFPSLR 357 Query: 483 PLGVKVDMTPIYG 495 + D+ G Sbjct: 358 LAVPEEDLRFKPG 370 >2WIY-A nrPDB Length = 394 Score = 116 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 67/434 (15%), Positives = 127/434 (29%), Gaps = 77/434 (17%) Query: 46 WPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKG 105 P NP+ R+ Q + V ++ G +V D A + G Sbjct: 11 VPW--SDPEFRNNPYPWYRRLQQDH-PVHKLEDG--TYLVSRYADVSHFAKLPIMSVEPG 65 Query: 106 RPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSK 165 D + + S + D P RR ++ V + Sbjct: 66 WADAGPWAVAS---DTALGSDP-PHHTVLRRQTNKWFTP------------KLVDGWV-R 108 Query: 166 EAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFG 225 L+ L + + R + V T+V A D + ++ Sbjct: 109 TTRELVGDLLDGVEAGQVIEARRDLAVVPTHVTMARVLQLPEDDADAVMEAMFE-----A 163 Query: 226 EVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSL 285 ++ S PAD + + + ++ V E + + DSL Sbjct: 164 MLMQSAEPAD------------GDVDRAAVA--FGYLSARVAEMLEDKRVNPGDGLADSL 209 Query: 286 IEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQE 345 ++ + ++++ + I +L + G + I+ + P V + Sbjct: 210 LDAARAG--------EITESEAIATILVFYAVGHMAIGYLIASGIELFARRPEVFTAFRN 261 Query: 346 ELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGR 405 + A I E R + T D + G I G Sbjct: 262 DESARA------------------AIINEMVRMDPP-QLSFLRFPTEDVEIGGVLIEAGS 302 Query: 406 CVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARW 465 + N D +++ +P F R + + + FG+G C G+ I+R Sbjct: 303 PIRFMIGAANRDPEVFDDPDVFDHTR---------PPAASRNLSFGLGPHSCAGQIISRA 353 Query: 466 EVFLFLAILLQRVE 479 E A+L +R E Sbjct: 354 EATTVFAVLAERYE 367 >3WEC-A nrPDB Length = 419 Score = 115 bits (288), Expect = 4e-26, Method: Composition-based stats. Identities = 45/282 (15%), Positives = 81/282 (28%), Gaps = 45/282 (15%) Query: 228 VGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQK--MVKEHYKTFEKGHIRDITDSL 285 V P + + + +P+ F + + + + + I + D Sbjct: 152 VAEPFPVEVLSSILGIPDKDRGRFSEWSNLVAGVLDINFAIPKEVADRRSAAIEESIDYF 211 Query: 286 IEHCQEKQLDEN----------ANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVM 335 E QLS ++I L + AG +T + I L+ Sbjct: 212 RTLATSGNAPEGLVRRLSEVSHGGDQLSVDEIAATCLLITVAGQETTSNTIGNMLITFSR 271 Query: 336 NPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTS 395 + ++ R++ ++E + E R D Sbjct: 272 HADQFEQV------------------RANPQFIENAVAEVLRFEPPA-HEAGRIALEDCE 312 Query: 396 LKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKR 455 + G I KG V V N + F R + +G G Sbjct: 313 VSGANITKGDAVMVLLASGNR--EAVERGDTFSVTR-----------PDVSSLSYGRGIH 359 Query: 456 KCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLT 497 C+G +A + FL L QR S+ + ++ P GL Sbjct: 360 HCLGSALANSMLQHFLRELSQRYR-SIEVAEPINYKPGMGLR 400 >2UUQ-A nrPDB Length = 414 Score = 114 bits (285), Expect = 9e-26, Method: Composition-based stats. Identities = 64/401 (15%), Positives = 128/401 (31%), Gaps = 69/401 (17%) Query: 95 ALVRQGDDFKGRPDLYTFT-----LISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIAS 149 L R D + D TF+ ++ G+ P + + Sbjct: 55 VLSRHADVWSAARDHQTFSSAQGLTVNYGELEMIGLHDTPPMVMQDPPVHTEFRKLV--- 111 Query: 150 DPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDH 209 T +E + ++ L++L A G + + + +++ A G + Sbjct: 112 -SRGFTPRQVETVEPTVRKFVVERLEKLRANGGG-DIVTELFKPLPSMVVAHYLGVPEED 169 Query: 210 NHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEH 269 Q + + + + + N D + A D ++ +++ Sbjct: 170 WTQ--------FDGWTQAIVAANAVD---------GATTGAL-DAVGSMMAYFTGLIERR 211 Query: 270 YKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWS 329 + D I H + + + + I+ + G DTVT + S Sbjct: 212 R--------TEPADDAISHLVAAGVGADGDTAGTL-SILAFTFTMVTGGNDTVTGMLGGS 262 Query: 330 LMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHS 389 + L P +R + ++ + + + E R +S V + + Sbjct: 263 MPLLHRRPDQRRLLLDDPEGI------------------PDAVEELLRLTSPVQ-GLART 303 Query: 390 TTRDTSLKGFYIPKGRCVFVNQWQINHDQKLW-VNPSEFLPERFLTPDGAIDKVLSEKVI 448 TTRD ++ IP GR V + N D++ + + +E R ++ Sbjct: 304 TTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTR-----------CPRNIL 352 Query: 449 IFGMGKRKCIGETIARWEVFLFLAILLQRV-EFSVPLGVKV 488 F G C+G AR + + L LL R +F V V Sbjct: 353 TFSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESRIV 393 >4PWV-A nrPDB Length = 446 Score = 114 bits (285), Expect = 9e-26, Method: Composition-based stats. Identities = 43/254 (16%), Positives = 82/254 (32%), Gaps = 45/254 (17%) Query: 254 LNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLD 313 + + ++V E + I + +S+++ L++E I+ Sbjct: 218 ARNEILLYFSELVAERRAKPTEDVISVLANSMVD-----------GKPLTEEVIVLNCYS 266 Query: 314 LFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFIL 373 L G +T ++ S+ P +++ T +E+ Sbjct: 267 LILGGDETSRLSMIDSVQTFTQYPDQWELLRDGKVT------------------LESATE 308 Query: 374 ETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFL 433 E R ++ + T D L G I G V + N D++++ +P F R Sbjct: 309 EVLRWATPAMHFGRRAVT-DMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDLNR-- 365 Query: 434 TPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAIL---LQRVEFSVPLGVKVDM 490 K I FG G C+G + R EV L L E + ++ Sbjct: 366 ---------SPNKHITFGYGPHFCLGAYLGRAEVHALLDALRTYTTGFEITGEP-QRIHS 415 Query: 491 TPIYGLTMKHACCE 504 + GL+ + Sbjct: 416 NFLTGLSRLPVRIQ 429 >6HQD-A nrPDB Length = 420 Score = 111 bits (278), Expect = 7e-25, Method: Composition-based stats. Identities = 60/418 (14%), Positives = 133/418 (31%), Gaps = 53/418 (12%) Query: 91 TIRQALVRQGDDFKGRPDLYTFTLISNGQSMSF--SPDSGPVWAARRRLAQNGL-KSFSI 147 + V + + F+ F + + + + + GP W+ + + + + Sbjct: 17 ALEDIDVSKPELFERDGLHPYFERLRREDPVHYCKASEYGPYWSITKFSDIVAIDTNHKV 76 Query: 148 ASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRY 207 S ++ S L++ + I L P + +R VV + + F Sbjct: 77 FSSDHTNGSFVLDDTTLNAVDGGIYLPNFLGMDPPKHDVHRMVVSPIVAPQNLLRFEATI 136 Query: 208 DHNHQELLSLVNLNNNF--GEVVGSGNPADFIPILRYLPNPSLNAFKDLN---------- 255 + +LS + + F + V + L P + Sbjct: 137 RERTKRVLSELPIGEEFNWVDRVSIELTTMMLATLLDFPFDDRRKLTRWSDIITTRPGYG 196 Query: 256 -----EKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINI 310 E+ S + + + + + + LI ++ L+ + Sbjct: 197 LVDSWEQRESELMECLAYFQRLYAERQAMPPKPDLISMLAHSPEMQD----LTPTDFLGT 252 Query: 311 VLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEA 370 + L G DT +++S S M + P+ K+ R++ + + Sbjct: 253 LALLIVGGNDTTRSSMSGSAMACHLYPQEFDKV------------------RNNRALLAS 294 Query: 371 FILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPE 430 I E R + + + + D +G I KG V + N D ++ P +F+ + Sbjct: 295 VIPEVVRWQTPIAH-MRRTALEDVEFRGKQIRKGDKVVMWYLSGNRDDEVIDRPMDFIAD 353 Query: 431 RFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKV 488 R + + FG G +C+G +A ++ + + +R G V Sbjct: 354 R----------PRARHHLSFGFGIHRCLGNRLAELQLKILWEEMCERYSRIEVCGEPV 401 >4FB2-A nrPDB Length = 398 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 49/331 (14%), Positives = 110/331 (33%), Gaps = 48/331 (14%) Query: 171 ISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSL-VNLNNN-FGEVV 228 + P H YR +V + F + + +L+ + L + Sbjct: 80 FELMMAGQDDPVHK-KYRQLVAKPFSPEATDLFTEQLRQSTNDLIDARIELGEGDAATWL 138 Query: 229 GSGNPADFIPILRYLPNPSLNAFKDLN---------EKFYSFMQKMVKEHYKTFEKGHIR 279 + PA IL LP + ++ E+ ++V H +T Sbjct: 139 ANEIPARLTAILLGLPPEDGDTYRRWVWAITHVENPEEGAEIFAELVA-HARTLIAERRT 197 Query: 280 DITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRV 339 + + ++ ++D + LS++ +I L G D +S L + + Sbjct: 198 NPGNDIMSRVIMSKIDGES---LSEDDLIGFFTILLLGGIDNTARFLSSVFWRLAWDIEL 254 Query: 340 QRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGF 399 +R++ +H + + E R P + T++ ++ Sbjct: 255 RRRL------------------IAHPELIPNAVDELLRFY--GPAMVGRLVTQEVTVGDI 294 Query: 400 YIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIG 459 + G+ + + D+ + +P + ER + + G G +C+G Sbjct: 295 TMKPGQTAMLWFPIASRDRSAFDSPDNIVIER-----------TPNRHLSLGHGIHRCLG 343 Query: 460 ETIARWEVFLFLAILLQRV-EFSVPLGVKVD 489 + R E + + L+R+ EFS+ + + Sbjct: 344 AHLIRVEARVAITEFLKRIPEFSLDPNKECE 374 >6G71-A nrPDB Length = 405 Score = 108 bits (270), Expect = 5e-24, Method: Composition-based stats. Identities = 77/430 (17%), Positives = 141/430 (32%), Gaps = 76/430 (17%) Query: 51 HMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLY 110 H+ L +NP R+ + V + +++ + A V Q F Sbjct: 15 HLADLYQNPFPIFERLRSE-SPVAWVPEAGR--YLITSYSGVLAADVDQ-TTFSANEK-K 69 Query: 111 TFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVL 170 + L + G SM D P RR Q LK ++ E+ + + Sbjct: 70 SLMLRAMGHSMLRKDD--PDHQVERRAWQPSLKPGTVKK----VWKQKFAENADRYLDAY 123 Query: 171 ISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGS 230 I F N+ I F + + Q + + Sbjct: 124 IDA-----GSGSDFMQGFAAPFVAENLRALIGFENASEADLQR------WSQTLIDG-AG 171 Query: 231 GNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQ 290 P D + K +++ + +++M++ H + G DSL+ + Sbjct: 172 NYPDDPDVWAKA---------KQSSDEIDAALEEMIQWH--SGRPG------DSLLSYLL 214 Query: 291 EKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTV 350 +A+ Q+ E I + + G G + + S + L+ + + + Sbjct: 215 R-----SADYQMPLESIRSNIKMTIGGGLNEPRDVLGVSTLALLSSSKQLELV------- 262 Query: 351 IGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVN 410 A E+ R + + +P T DT L G++IP+G + + Sbjct: 263 -----------LRDPKLWGAVFEESIRWVAPIGM-VPRQTVVDTELDGYFIPRGAKLGLC 310 Query: 411 QWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVF-L 469 N D+ +W +P F ER SE + FG G C+G AR +V + Sbjct: 311 ILSANRDRSVWSDPDRFDIER-----------GSEAHLAFGKGVHVCLGAWAARSQVADV 359 Query: 470 FLAILLQRVE 479 L L R++ Sbjct: 360 GLPALFSRLK 369 >6BLD-A nrPDB Length = 419 Score = 107 bits (267), Expect = 1e-23, Method: Composition-based stats. Identities = 44/216 (20%), Positives = 66/216 (30%), Gaps = 32/216 (14%) Query: 261 FMQKMVKEHYKTFEKGHIRD-ITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGF 319 F +M RD D L ++D +L+D + + L AG Sbjct: 206 FENQMYLHQVAASLAAERRDRPGDDLFSALVNAEVD---GDRLADADVAAFFVLLAVAGN 262 Query: 320 DTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHS 379 DT IS L L P + + + DT IG + E R + Sbjct: 263 DTTRQTISHGLKALTDFPSQKAWLLADFDTRIG-----------------TAVEELVRWA 305 Query: 380 SFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAI 439 + V T + D L G I G V + N D+ + +P R P Sbjct: 306 TPV-MTFRRTAAADFELGGQLIRAGEKVVMFYASGNWDEDAFCHPERLDLSRSPNPHVGF 364 Query: 440 DKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILL 475 C+G +AR ++ LL Sbjct: 365 GGGGVHF----------CLGAHLARAQLRAIFGELL 390 >3B98-A nrPDB Length = 475 Score = 106 bits (265), Expect = 2e-23, Method: Composition-based stats. Identities = 78/496 (15%), Positives = 167/496 (33%), Gaps = 67/496 (13%) Query: 39 NPPGPWG-WPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALV 97 PP G P +GH L GK+ L+RM +++GD+ +R + VL + L Sbjct: 19 EPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVLLDSNCYDAVLS 78 Query: 98 RQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSC 157 ++ + +R+ L S + S+ + Sbjct: 79 D----------------------VASLDQTSYAQVLMKRIFNMILPSHNPESEKKRAEMH 116 Query: 158 YLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSL 217 + +++ + + + L+ + + + F Y + Sbjct: 117 FQGASLTQLSNSMQNNLR-------LLMTPSEMGLKTSEWKKDGLFNLCYSLLFKTGYLT 169 Query: 218 VNLNNNFGEVVGSGNPADFIPILRYLPNPSLN-AFKDLNEKFYSFMQKMVKEHYKTFEKG 276 V N + +F + LP + K+ + + +K+ K + Sbjct: 170 VFGAENNNSAALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASAAREKLWKWLTPSGLDR 229 Query: 277 HIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFG----AGFDTVTTAISWSLMY 332 R+ S + ++ DE + ++ + ++L L+ AG A W + Y Sbjct: 230 KPRE--QSWLGSYVKQLQDEGIDAEM---QRRAMLLQLWVTQGNAGP-----AAFWVMGY 279 Query: 333 LVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR 392 L+ +P R ++EE+ G + + P ++ + ET R + I T+ Sbjct: 280 LLTHPEALRAVREEIQ---GGKHLRLEERQKNTPVFDSVLWETLRLT--AAALITRDVTQ 334 Query: 393 DTSL-----KGFYIPKGRCVFVNQW-QINHDQKLWVNPSEFLPERFLTPDGAIDK----- 441 D + + +++ +G + V + D ++ P F +RFL D K Sbjct: 335 DKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKN 394 Query: 442 --VLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLG---VKVDMTPIYGL 496 + + +G C G A + + +L R + + V + YG Sbjct: 395 GARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGF 454 Query: 497 -TMKHACCEHFQMQLR 511 ++ A + ++R Sbjct: 455 GILQPAGDLEIRYRIR 470 >5HIW-A nrPDB Length = 398 Score = 106 bits (264), Expect = 3e-23, Method: Composition-based stats. Identities = 60/396 (15%), Positives = 129/396 (32%), Gaps = 76/396 (19%) Query: 84 VVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLK 143 VVL G D + A++R + F R + G RRL L Sbjct: 41 VVLRGADVV--AVLRDSETFSTRTYDTGIMK------GALVTLGGEAHTRMRRLFNAVLS 92 Query: 144 SFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICF 203 S Y E V+ A ++ L + + + VT+ + + Sbjct: 93 P--------RVISRYEEATVTPVARRVVERLVRKERAELFDDFAISMPMGVTSALFGLP- 143 Query: 204 GRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQ 263 R N + ++ P D + + + + + ++ Sbjct: 144 EERIAENDALIRKMIR---------SVVMPQDPVVVAEG---------RSAHAAMEAQLR 185 Query: 264 KMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVT 323 ++ + D+L+ + E E +VL L ++T + Sbjct: 186 EIAEREVAHPS--------DTLLGEIARAIVAEGLGGV---EACEGVVLTLILGSYETTS 234 Query: 324 TAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVP 383 ++ L+ L+ +P +++++ + I E+ R S Sbjct: 235 WMLANLLVALLAHPDAMNQLRQQPS------------------LLPQAIEESTRWCSSAA 276 Query: 384 FTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVL 443 I R+ ++ G + G ++++ ++D++++ P F R Sbjct: 277 -GIVRFVEREATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDIHR-----------R 324 Query: 444 SEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 ++ FG G C+G +AR E + +++LL+R Sbjct: 325 PVGMLNFGGGLHYCVGAPLARMEARVGVSLLLERFP 360 >2QBO-A nrPDB Length = 421 Score = 105 bits (262), Expect = 4e-23, Method: Composition-based stats. Identities = 51/299 (17%), Positives = 102/299 (34%), Gaps = 48/299 (16%) Query: 196 NVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLN-----A 250 + C++ R ++ +G P + IP L+YL + Sbjct: 134 ELACSLIESLRPQGQCNFTEDYAEPFPIRIFMLLAGLPEEDIPHLKYLTDQMTRPDGSMT 193 Query: 251 FKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINI 310 F + E Y ++ ++++ + I + + + ++ ++ + Sbjct: 194 FAEAKEALYDYLIPIIEQRRQKPGTDAISIVANG-----------QVNGRPITSDEAKRM 242 Query: 311 VLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEA 370 L G DTV +S+S+ +L +P ++++ E + + A Sbjct: 243 CGLLLVVGLDTVVNFLSFSMEFLAKSPEHRQELIERPERI------------------PA 284 Query: 371 FILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPE 430 E R S V T D G + KG + + Q D++ P Sbjct: 285 ACEELLRRFSLVADG--RILTSDYEFHGVQLKKGDQILLPQMLSGLDERENACPMHVDFS 342 Query: 431 RFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV-EFSVPLGVKV 488 R FG G C+G+ +AR E+ + L L R+ +FS+ G ++ Sbjct: 343 R-----------QKVSHTTFGHGSHLCLGQHLARREIIVTLKEWLTRIPDFSIAPGAQI 390 >2NZA-A nrPDB Length = 413 Score = 104 bits (260), Expect = 8e-23, Method: Composition-based stats. Identities = 46/285 (16%), Positives = 92/285 (32%), Gaps = 51/285 (17%) Query: 220 LNNNFGEVVGSGNPADFIP-ILRYLPN---------PSLNAFKDLNEKFYSFMQKMVKEH 269 L+ ++ G PAD + +L P P+ + + + E Sbjct: 131 LDGLVDGILAEGPPADLVERVLEPFPIAVVSEVMGVPAADRERVHSWTRQIISTSGGAEA 190 Query: 270 YKTFEKGHIRDITDSLIEHCQEKQLD-------ENANVQLSDEKIINIVLDLFGAGFDTV 322 + ++G IT+++ + D ++ + + + + L G + V Sbjct: 191 AERAKRGLYGWITETVRARAGSEGGDVYSMLGAAVGRGEVGETEAVGLAGPLQIGG-EAV 249 Query: 323 TTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSF- 381 T + L L+ + +++E + E R S Sbjct: 250 THNVGQMLYLLLTRRELMARMRERPGAR------------------GTALDELLRWISHR 291 Query: 382 VPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDK 441 + D + G I G V+V+ N D ++ +P +R P Sbjct: 292 TSVGLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDRDPNP------ 345 Query: 442 VLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR---VEFSVP 483 + +G G C G +AR + L + LL+R + +VP Sbjct: 346 -----HLAYGNGHHFCTGAVLARMQTELLVDTLLERLPGLRLAVP 385 >2IAG-A nrPDB Length = 482 Score = 104 bits (260), Expect = 8e-23, Method: Composition-based stats. Identities = 79/489 (16%), Positives = 167/489 (34%), Gaps = 78/489 (15%) Query: 27 RASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVL 86 R RP P P P +G+ L GK+ L+RM +++GD+ I +G V VL Sbjct: 1 RTRRPGEP-----PLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVL 55 Query: 87 SGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFS 146 + + T + F R+ L +S Sbjct: 56 LDPHSYDAVV------------WEPRTRLDFHAYAIFL---------MERIFDVQLPHYS 94 Query: 147 IASDPASSTSCYLEEHVSKEAEVLISTL------QELMAGPG-------HFNPYRYVVVS 193 + + A L + E + + L AG G F+ + Sbjct: 95 PSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAG 154 Query: 194 VTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKD 253 + R ++ Q+ + ++ + F ++ L + Sbjct: 155 YLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLA----RGSLSVGDKDHMCS 210 Query: 254 LNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLD 313 + + + + + + H +S + H +E + E + ++ Sbjct: 211 VKSRLWKLLSPA-----RLARRAHRSKWLESYLLHLEEMGVSEEMQAR--------ALVL 257 Query: 314 LFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHL-------P 366 A + A W L++L+ NP ++ EL++++ ++ +P + P Sbjct: 258 QLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTP 317 Query: 367 YMEAFILETFRHSSFVPFTIPHSTTRDTSL-----KGFYIPKGRCVFVNQ-WQINHDQKL 420 +++ + E+ R + PF I D ++ + F + +G + + D ++ Sbjct: 318 VLDSVLSESLRL-TAAPF-ITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEI 375 Query: 421 WVNPSEFLPERFLTPDGAID-------KVLSEKVIIFGMGKRKCIGETIARWEVFLFLAI 473 + +P F RFL PDG+ K L + +G G C+G + A + F+ + Sbjct: 376 YTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFL 435 Query: 474 LLQRVEFSV 482 +L ++ + Sbjct: 436 VLVHLDLEL 444 >5EX8-A nrPDB Length = 424 Score = 103 bits (257), Expect = 2e-22, Method: Composition-based stats. Identities = 44/291 (15%), Positives = 83/291 (28%), Gaps = 47/291 (16%) Query: 204 GRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPS-----LNAFKDLNEKF 258 RR + +V ++ + G P DF+P + L +D Sbjct: 139 HRRMQKFRPRVEQIVQ--DSLDTIESLGGPVDFVPHFGWAIATPATCDFLGIPRDDQADL 196 Query: 259 YSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDEN----------ANVQLSDEKII 308 + + + +H + + ++D ++ Sbjct: 197 ARILLASRTDRSDKRRTAAGNKFMTYMKQHVAQSRRGSGDDLFGIVGRENGDAITDAELT 256 Query: 309 NIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYM 368 + + GA D V ++ +V P ++E+ +TV P D Sbjct: 257 GVAAFVMGAAADQVARLLAAGAWLMVEQPAQFALLREKPETV------PEWLD------- 303 Query: 369 EAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFL 428 ET R+ + T P T+D + + G V + N EF Sbjct: 304 -----ETMRYLTTDEKTHPRVATQDVRIGNQLVKAGDTVTCSLLAANR-PNYPSAEDEFD 357 Query: 429 PERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 R + + FG G C+G +A + + L R Sbjct: 358 ITR-----------EKAEHLAFGHGIHHCLGRAMAELMFKVSIPALAHRFP 397 >3BUJ-A nrPDB Length = 397 Score = 103 bits (257), Expect = 2e-22, Method: Composition-based stats. Identities = 35/180 (19%), Positives = 64/180 (35%), Gaps = 30/180 (16%) Query: 287 EHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEE 346 E LD + +S +I++ V+ G +TV + + +++ L+ +P ++ Sbjct: 203 EDLLALMLDAHDRGLMSRNEIVSTVVTFIFTGHETVASQVGNAVLSLLAHPDQLDLLRRR 262 Query: 347 LDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRC 406 D + + E R+ V D L+G + + Sbjct: 263 PD------------------LLAQAVEECLRYDPSVQSNT-RQLDVDVELRGRRLRRDDV 303 Query: 407 VFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWE 466 V V N D + + P +F ER P + FG G R C+G +AR + Sbjct: 304 VVVLAGAANRDPRRYDRPDDFDIERDPVPS-----------MSFGAGMRYCLGSYLARTQ 352 >5KYO-A nrPDB Length = 430 Score = 102 bits (254), Expect = 4e-22, Method: Composition-based stats. Identities = 69/418 (16%), Positives = 131/418 (31%), Gaps = 53/418 (12%) Query: 97 VRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRR-LAQNGLKSFS--------I 147 V +G DF + ++P +G W A R LA+ + F + Sbjct: 53 VPEGLDFHQSWREIMRQAPHP---LMWTPHNGGHWVALRSDLAETVMSDFERFSNHTVLV 109 Query: 148 ASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRY 207 + A + + +L GP P V VT++ ++ G R Sbjct: 110 PKETAGEAYRLIPLSLDPPEHRPFRSLLNENLGPKPLRPIEQV---VTDLAVSLIEGFRP 166 Query: 208 DHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVK 267 + P + +P L++L + + + K + Sbjct: 167 KGRCNFTHEFAEQLPVRIFMRIVDLPVEDLPKLKHL---ADQYTRPDGSIPLDDVTKQFR 223 Query: 268 EHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAIS 327 E+ + + + +I ++ L+D + NI + + G DTV + Sbjct: 224 EYLRPVIEARRIKPGEDMISRMINGEV---GGRPLTDIEAENICIQVLVGGLDTVVNMLG 280 Query: 328 WSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIP 387 ++ +L + ++R I + ++ +LE FR V Sbjct: 281 FTFSHLAKDHALRRAIAADPS------------------LIDDALLEFFRRFPVVSSA-- 320 Query: 388 HSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKV 447 RD +G + G V + D +P EF R + + Sbjct: 321 REVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDPLEFRLGRK-----------ARQH 369 Query: 448 IIFGMGKRKCIGETIARWEVFLFLAILLQRV-EFSVPLGVKVDMTPIYGLTMKHACCE 504 FG G C G +AR E+ + L R+ EF + + + ++K E Sbjct: 370 STFGKGSHTCPGAHLARMEMKVVLREWFARIPEFRIEDDAPLRYSNGIVGSVKPFVLE 427 >5D3U-A nrPDB Length = 427 Score = 102 bits (253), Expect = 5e-22, Method: Composition-based stats. Identities = 38/232 (16%), Positives = 78/232 (33%), Gaps = 38/232 (16%) Query: 281 ITDSLIEHCQEKQLD-ENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRV 339 + D++I Q + + ++ + + LF T ++S + NPR Sbjct: 233 LPDTVIARLAAAQDGLTETTPEQTVHQLALVFIALFAP---TTPGSLSSGTLAFARNPRQ 289 Query: 340 QRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGF 399 + + V + E R+++ FT +D + G Sbjct: 290 VERFLADQACV------------------DNTANEVLRYNASNQFTW-RVAAKDVEMGGV 330 Query: 400 YIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIG 459 I G+ + + N D ++ P++F +R S + + FG G C+ Sbjct: 331 RIEAGQTLALFLGSANRDANMFERPNDFDLDR----------PNSARHLSFGQGVHACLA 380 Query: 460 ETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLR 511 + ++ F LL R G++ PI+ ++ + LR Sbjct: 381 AQLISLQLKWFYVALLNRF-----PGIRTAGEPIWNENLEFRSLRSLPLSLR 427 >5OMS-A nrPDB Length = 409 Score = 97.1 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 66/459 (14%), Positives = 134/459 (29%), Gaps = 75/459 (16%) Query: 52 MLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYT 111 M L +NP+ R+ + +GS V S + R+ PD Sbjct: 19 MTQLERNPYEVYERLRAEAPLAFVPVLGS---YVASTAEVCREV--------ATSPDFEA 67 Query: 112 FTLISNGQSM---SFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAE 168 + G++ + +G + A R + + L+ + ++++ V A Sbjct: 68 VITPAGGRTFGHPAIIGVNGDIHADLRSMVEPALQP--------AEVDRWIDDLVRPIAR 119 Query: 169 VLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVV 228 + + + + +V + G + L F ++ Sbjct: 120 RYLERFEN--------DGHAELVAQYCEPVSVRSLGDLLGLQEVDSDKLREW---FAKLN 168 Query: 229 GSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEH 288 S A + + + + ++ + + + DS I H Sbjct: 169 RSFTNAAVDENGEFANPEGFAEGDQAKAEIRAVVDPLIDKWIEHPD--------DSAISH 220 Query: 289 CQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELD 348 + E I + ++ +L+ L P ++ Sbjct: 221 WLHDGMPPGQTR--DREYIYPTIYVYLLGAMQEPGHGMASTLVGLFSRPEQLEEV----- 273 Query: 349 TVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVF 408 + D + +P I E R +S + +T+ ++ G +P G V Sbjct: 274 ----------VDDPTLIP---RAIAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTPVM 320 Query: 409 VNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVF 468 ++ NHD + PS++ R + FG G C G A + Sbjct: 321 LSYGSANHDTGKYEAPSQYDLHR-----------PPLPHLAFGAGNHACAGIYFANHVMR 369 Query: 469 LFLAILLQ---RVEFSVPLGVKVDMTPIYGLTMKHACCE 504 + L L + +E GV+ G T H E Sbjct: 370 IALEELFEAIPNLERDTREGVEFWGWGFRGPTSLHVTWE 408 >3NV6-A nrPDB Length = 452 Score = 87.1 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 53/285 (18%), Positives = 92/285 (32%), Gaps = 47/285 (16%) Query: 223 NFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIR--D 280 +F P L LP + + + +E E G+ Sbjct: 185 DFAAEYAELFPVHVFMALADLPLEDIPVLSEYARQMTRPEGNTPEEMATDLEAGNNGFYA 244 Query: 281 ITDSLIEHCQEKQLD---------ENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLM 331 D +I D E +++ +K ++ L G DTV +S+ ++ Sbjct: 245 YVDPIIRARVGGDGDDLITLMVNSEINGERIAHDKAQGLISLLLLGGLDTVVNFLSFFMI 304 Query: 332 YLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTT 391 +L +P + +++ + ++ + E FR V Sbjct: 305 HLARHPELVAELRSDPLKLMRGA------------------EEMFRRFPVVSEA--RMVA 344 Query: 392 RDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFG 451 +D KG ++ +G + + D P + R S FG Sbjct: 345 KDQEYKGVFLKRGDMILLPTALHGLDDAANPEPWKLDFSR-----------RSISHSTFG 393 Query: 452 MGKRKCIGETIARWEVFLFLAILLQRV-EFSVPLGVKVDMTPIYG 495 G +C G +AR EV + L L+R+ EFS G TPIY Sbjct: 394 GGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGE----TPIYH 434 >4C9K-A nrPDB Length = 421 Score = 84.0 bits (206), Expect = 2e-16, Method: Composition-based stats. Identities = 44/271 (16%), Positives = 79/271 (29%), Gaps = 48/271 (17%) Query: 223 NFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDI- 281 FG + P L LP L + +E ++ E + Sbjct: 151 EFGSEFSTVFPVRVFLALAGLPVEDATKLGLLANEMTRPSGNTPEEQGRSLEAANKGFFE 210 Query: 282 -------------TDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISW 328 LI ++D + D++ + +V L G DTV + + Sbjct: 211 YVAPIIAARRGGSGTDLITRILNVEID---GKPMPDDRALGLVSLLLLGGLDTVVNFLGF 267 Query: 329 SLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPH 388 ++YL +P +++ E ++ + E FR + V Sbjct: 268 MMIYLSRHPETVAEMRREPLK------------------LQRGVEELFRRFAVVSDA--R 307 Query: 389 STTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVI 448 D G + +G + + D + +P R Sbjct: 308 YVVSDMEFHGTMLKEGDLILLPTALHGLDDRHHDDPMTVDLSR-----------RDVTHS 356 Query: 449 IFGMGKRKCIGETIARWEVFLFLAILLQRVE 479 F G +C G +AR EV + L L R+ Sbjct: 357 TFAQGPHRCAGMHLARLEVTVMLQEWLARIP 387 >2RCM-A nrPDB Length = 495 Score = 79.4 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 30/183 (16%), Positives = 69/183 (37%), Gaps = 20/183 (10%) Query: 338 RVQRKIQEELDTVI-GRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSL 396 +V ++ EE+ +VI + + ++ + E R V +D + Sbjct: 316 QVHNRLAEEIRSVIKSNGGELTMGAIEKMELTKSVVYECLRFEPPVTAQYGR-AKKDLVI 374 Query: 397 KGFY----IPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGM 452 + + G ++ Q D K++ EF+PERF+ +G + +++ Sbjct: 375 ESHDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEEGEKLL----RHVLWSN 430 Query: 453 GK---------RKCIGETIARWEVFLFLAILLQRVE-FSVPLGVKVDMTPIYGLTMKHAC 502 G ++C G+ LF+ + +R + F + +G + + +++ A Sbjct: 431 GPETETPTVGNKQCAGKDFVVLVARLFVIEIFRRYDSFDIEVGTSPLGSSVNFSSLRKAS 490 Query: 503 CEH 505 H Sbjct: 491 FHH 493 >3DBM-A nrPDB Length = 473 Score = 76.0 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 79/503 (15%), Positives = 153/503 (30%), Gaps = 74/503 (14%) Query: 35 KGLKNPPGPWGWPLIGHM-----LTLGKNP-HLALSRMSQQY-GDVLQIRIGSTP----- 82 K L+ PG +G P + G Q+Y V + + P Sbjct: 6 KPLREIPGSYGIPFFQPIKDRLEYFYGTGGRDEYFRSRMQKYQSTVFRANMPPGPFVSSN 65 Query: 83 --VVVLSGLDTIRQAL----VRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRR 136 V+VL + V + D F G + + L + +S+ S P A + Sbjct: 66 PKVIVLLDAKSFPILFDVSKVEKKDLFTG-TYMPSTKLTGGYRVLSYLDPSEPRHAQLKN 124 Query: 137 LAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTN 196 L F + + ++ E ++ L L+ +A G + Sbjct: 125 LL------FFMLKNSSNRVIPQFETTYTE----LFEGLEAELAKNGKAAFNDVGEQAAFR 174 Query: 197 VICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILR-----YLPNPSLNAF 251 + F + L + ++ S + P L +L P L+ F Sbjct: 175 FLGRAYFNSNPEET--------KLGTSAPTLISSWVLFNLAPTLDLGLPWFLQEPLLHTF 226 Query: 252 KDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIV 311 + S K+ ++ + + + + Sbjct: 227 RLPAFLIKSTYNKLYDYFQSVATP------------VMEQAEKLGVPKDEAVHNILFAVC 274 Query: 312 LDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGR--SRRPRLSDRSHLPYME 369 + FG + W + N Q + EE+ I L +P + Sbjct: 275 FNTFGGVKILFPNTLKWIGLA-GENLHTQ--LAEEIRGAIKSYGDGNVTLEAIEQMPLTK 331 Query: 370 AFILETFRHSSFVPFTIPHSTTRDTSLKGFY----IPKGRCVFVNQWQINHDQKLWVNPS 425 + + E+ R VP + +++ + KG +F Q D K++ P Sbjct: 332 SVVYESLRIEPPVPPQYG-KAKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPE 390 Query: 426 EFLPERFLTPDGAIDKVLSEKVIIFGMGK----RKCIGETIARWEVFLFLAILLQRVEF- 480 E++P+RF+ A+ K + ++C G+ LF+ L +R + Sbjct: 391 EYVPDRFVGDGEALLKYVWWSNGPETESPTVENKQCAGKDFVVLITRLFVIELFRRYDSF 450 Query: 481 -----SVPLGVKVDMTPIYGLTM 498 PLG V +T + ++ Sbjct: 451 EIELGESPLGAAVTLTFLKRASI 473 >2YJN-B nrPDB Length = 381 Score = 56.3 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 19/137 (13%), Positives = 39/137 (28%), Gaps = 22/137 (16%) Query: 311 VLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEA 370 L AG + + +++ + P + +I ++ + Sbjct: 216 ALRALFAGAEMTANTVVDAVLAVSAEPGLAERIADDPAA------------------AQR 257 Query: 371 FILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPE 430 + E R + + T + L I +G V V N D +++ P + Sbjct: 258 TVAEVLRLHPALHLE-RRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVD 316 Query: 431 RFLTPDGAIDKVLSEKV 447 R PD Sbjct: 317 R---PDADRALSAHRGH 330 >3HGT-A nrPDB Length = 328 Score = 32.0 bits (71), Expect = 0.68, Method: Composition-based stats. Identities = 22/101 (21%), Positives = 32/101 (31%), Gaps = 2/101 (1%) Query: 142 LKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVI--C 199 + I S L+ V + + LQ G V + N I C Sbjct: 183 FTKYPIKSKARFDMLICLDTTVDTSQKDIQYLLQYKRERKGLERYAPIVRLVAINSIDHC 242 Query: 200 AICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL 240 + FG+++D N +E L V P D PI Sbjct: 243 RLFFGKKFDKNSREYLENVTAAMVILRDRLGTLPPDLRPIY 283 >5L9W-B nrPDB Length = 732 Score = 30.9 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 16/85 (18%), Positives = 34/85 (40%), Gaps = 2/85 (2%) Query: 264 KMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV--QLSDEKIINIVLDLFGAGFDT 321 + V E + + + + +++D + +V L +E + + L G Sbjct: 116 QRVAERRNIAVQNKPLPLIERDLILGVRERIDSSGSVVRPLDEEDVRTKLRMLMDRGARA 175 Query: 322 VTTAISWSLMYLVMNPRVQRKIQEE 346 + ++ WS M RV+ I+EE Sbjct: 176 IVVSLLWSFMNPAHEKRVREIIREE 200 >4YXC-B nrPDB Length = 227 Score = 30.9 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 10/48 (20%), Positives = 15/48 (31%), Gaps = 2/48 (4%) Query: 364 HLPYMEAFILETFRHSSFVPFTIPHSTTR--DTSLKGFYIPKGRCVFV 409 L I E R + + D + G+ I +G V V Sbjct: 157 ELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVV 204 >4YXB-D nrPDB Length = 80 Score = 30.9 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 10/49 (20%), Positives = 15/49 (30%), Gaps = 2/49 (4%) Query: 363 SHLPYMEAFILETFRHSSFVPFTIPHSTTR--DTSLKGFYIPKGRCVFV 409 L I E R + + D + G+ I +G V V Sbjct: 9 DELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVV 57 >5EY3-A nrPDB Length = 442 Score = 30.5 bits (67), Expect = 1.7, Method: Composition-based stats. Identities = 20/91 (21%), Positives = 35/91 (38%), Gaps = 1/91 (1%) Query: 282 TDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQR 341 D+L+ + +LS+ IV GAG T ++ L + Sbjct: 198 LDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTA-LLTDMNQVLASSAGNAV 256 Query: 342 KIQEELDTVIGRSRRPRLSDRSHLPYMEAFI 372 +++E + + G R PRL D + +E I Sbjct: 257 EVREAVQFLTGEYRNPRLFDVTMALCVEMLI 287 >4YYC-A nrPDB Length = 525 Score = 30.5 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 26/142 (18%), Positives = 48/142 (33%), Gaps = 12/142 (8%) Query: 93 RQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAA-----RRRLAQNGLKSF-- 145 R+ L DF G++ F+P GP + RR ++F Sbjct: 107 RELLKTAPKDFTWHARNPERNAQIGGKATVFAPVYGPPFVRDLDGNRRYATIEDFRNFVK 166 Query: 146 -SIASDPASSTSCYLEE----HVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICA 200 + + S+ + E V+K ++ + P + T + Sbjct: 167 LAYMAPSMHSSGGTVCEPVDIAVNKRHLDMVYSHIRYSDKPFMGSVTAPERAEDTVAMAK 226 Query: 201 ICFGRRYDHNHQELLSLVNLNN 222 I FG + N+ L+L+N N+ Sbjct: 227 ILFGDDFVENNAVTLNLINANS 248 >5CQF-A nrPDB Length = 443 Score = 30.1 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 20/119 (16%), Positives = 38/119 (31%), Gaps = 32/119 (26%) Query: 377 RHSSFVPFTIPHSTTRDTSLKGFYI--PKGR----CVFVNQWQINHDQKLWVN---PSEF 427 R + V P R+ L+ + P+G + ++ + + P+ F Sbjct: 130 RFDTPVTEIDP--VIRNGRLQEVRVRTPQGSFATRNLVLSSGSAPRIPQAFEALLGPTLF 187 Query: 428 LPERFLTPDGAIDKVLSEKVIIFGMG---------------------KRKCIGETIARW 465 RFLT A K L ++ ++ G G +C G + + Sbjct: 188 HTSRFLTRLQAFGKQLPKRWLVLGSGQSASESVLELVSRDPAIEVHSVHRCAGFKLTQL 246 >2YMZ-A nrPDB Length = 130 Score = 30.1 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 17/76 (22%), Positives = 31/76 (40%), Gaps = 2/76 (2%) Query: 143 KSFSIAS-DPASSTSCYLEEHVSKEAEVLISTL-QELMAGPGHFNPYRYVVVSVTNVICA 200 + F + + D S + ++ H+S++AE L + HFNP V V N +C+ Sbjct: 2 RMFEMFNLDWKSGGTMKIKGHISEDAESFAINLGCKSSDLALHFNPRFNESVIVCNSLCS 61 Query: 201 ICFGRRYDHNHQELLS 216 + + H Sbjct: 62 DNWQQEQRDKHFNFYK 77 >6IRV-A nrPDB Length = 508 Score = 29.7 bits (65), Expect = 2.9, Method: Composition-based stats. Identities = 32/189 (16%), Positives = 57/189 (30%), Gaps = 21/189 (11%) Query: 101 DDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLE 160 + F LY ++ I + F P VW RR F + + L Sbjct: 278 NYFSKLWLLYRYSCIDDSAFERFLPR---VWCLLRRYQMM----FGVGLYEGTGLQGSLP 330 Query: 161 EHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSV-------TNVICAIC--FGRRYDHNH 211 HV + L E A P + +Y + C ++ N Sbjct: 331 VHVFEALHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFAPLSGSFEANP 390 Query: 212 QELLSLVNLNNNFGE--VVGSGNPADFIPILRYL---PNPSLNAFKDLNEKFYSFMQKMV 266 L++ + E + S P FI + P P+L + K + + Sbjct: 391 PFCEELMDAMVSHFERLLESSPEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLILPAF 450 Query: 267 KEHYKTFEK 275 + Y++ + Sbjct: 451 EHEYRSGSQ 459 >2NYG-A nrPDB Length = 273 Score = 29.7 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 10/52 (19%), Positives = 14/52 (26%), Gaps = 2/52 (3%) Query: 398 GFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVII 449 +G V +Q D K W NP PE + + Sbjct: 58 DVVTEEGTIVMPSQSVELSDPKEWGNPPV--PEEWWDIIRESMPAYNSNYTP 107 >4DJD-D nrPDB Length = 323 Score = 29.0 bits (63), Expect = 5.0, Method: Composition-based stats. Identities = 7/47 (14%), Positives = 17/47 (36%), Gaps = 10/47 (21%) Query: 310 IVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRR 356 L AG + L+ +P +++E +D ++ + Sbjct: 287 TATALLQAGAH----------ILLMRHPEAVARVKENIDQLMVSNAY 323 >2BKC-A nrPDB Length = 156 Score = 29.0 bits (63), Expect = 5.7, Method: Composition-based stats. Identities = 7/60 (11%), Positives = 25/60 (41%) Query: 258 FYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGA 317 F++ E + + + + L+ + + + ++L+D++ ++ D+ A Sbjct: 75 LKEFLENASVEEAPYTKPKTMDQLMEDLVGTLELLRDEYKQGIELTDKEGDDVTNDMLIA 134 >4J6E-A nrPDB Length = 283 Score = 28.6 bits (62), Expect = 6.0, Method: Composition-based stats. Identities = 19/95 (20%), Positives = 28/95 (29%), Gaps = 7/95 (7%) Query: 385 TIPHSTTRDTSLKGFYIPKGRCVFVNQWQI-NHDQKLWVNPSEFLPERFLTPDGAIDKVL 443 + + +GF I V K+ P E D A+D Sbjct: 109 ALLRRVLDEFEKEGFEIEGAHEVMGEMTLPRGRLGKVSPAP-----EHMADIDKALDVAR 163 Query: 444 SEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRV 478 + G G C G +A E +L+RV Sbjct: 164 EIGRLDIGQGAVVCEGLVLA-VEAQEGTDAMLRRV 197 >3RFT-A nrPDB Length = 267 Score = 28.6 bits (62), Expect = 6.7, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 16/55 (29%), Gaps = 13/55 (23%) Query: 411 QWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARW 465 NH + P+ PDG G KC GE +AR Sbjct: 108 FASSNHTIGYYPQTERLGPDVPARPDGL-------------YGVSKCFGENLARM 149 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.313 0.126 0.331 Lambda K H 0.267 0.0386 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,170,733 Number of Sequences: 36641 Number of extensions: 728806 Number of successful extensions: 2942 Number of sequences better than 10.0: 184 Number of HSP's better than 10.0 without gapping: 240 Number of HSP's successfully gapped in prelim test: 99 Number of HSP's that attempted gapping in prelim test: 1979 Number of HSP's gapped (non-prelim): 368 length of query: 512 length of database: 10,336,785 effective HSP length: 101 effective length of query: 411 effective length of database: 6,636,044 effective search space: 2727414084 effective search space used: 2727414084 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.5 bits) S2: 61 (28.2 bits)