BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P04397 (699 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1Z45-A nrPDB 1450 0.0 4LIS-A nrPDB 429 e-120 1I3M-A nrPDB 370 e-102 3ENK-A nrPDB 360 e-99 1UDA-A nrPDB 336 3e-92 1YGA-A nrPDB 335 4e-92 2C20-A nrPDB 251 1e-66 4WOK-A nrPDB 203 2e-52 1GY8-A nrPDB 187 1e-47 1SNZ-A nrPDB 146 3e-35 1LUR-A nrPDB 101 9e-22 6BI4-A nrPDB 99 6e-21 4RNL-A nrPDB 98 1e-20 6BWL-A nrPDB 87 2e-17 1BXK-A nrPDB 87 2e-17 1KEU-A nrPDB 86 4e-17 1L7J-A nrPDB 82 6e-16 3RUE-A nrPDB 79 7e-15 2HUN-A nrPDB 78 1e-14 1ORR-A nrPDB 74 3e-13 2Q1T-A nrPDB 71 2e-12 1OC2-A nrPDB 69 1e-11 2PZM-A nrPDB 68 2e-11 1R66-A nrPDB 68 2e-11 3IMH-A nrPDB 65 1e-10 1WVG-A nrPDB 63 5e-10 2PK3-A nrPDB 63 5e-10 4EJ0-A nrPDB 60 2e-09 1GFS-A nrPDB 60 3e-09 2Q1W-A nrPDB 57 2e-08 3M2P-A nrPDB 55 1e-07 3SXP-A nrPDB 54 2e-07 5UZH-A nrPDB 52 8e-07 2Z95-A nrPDB 51 2e-06 1DB3-A nrPDB 50 4e-06 2X86-A nrPDB 48 1e-05 1EQ2-A nrPDB 48 2e-05 6GPK-A nrPDB 47 3e-05 1RPN-A nrPDB 45 8e-05 4R1T-A nrPDB 44 2e-04 4BZF-A nrPDB 43 5e-04 1RKX-A nrPDB 42 8e-04 4G5H-A nrPDB 42 0.001 1N7G-A nrPDB 41 0.002 3SLK-A nrPDB 40 0.003 2GN9-A nrPDB 40 0.005 2NNL-D nrPDB 39 0.011 2C54-A nrPDB 38 0.018 4WKG-A nrPDB 37 0.021 4J2O-A nrPDB 37 0.028 5IZ4-A nrPDB 36 0.051 5ILO-A nrPDB 36 0.072 2P4H-X nrPDB 35 0.077 5B6K-A nrPDB 35 0.090 3OS7-A nrPDB 35 0.10 4BKP-A nrPDB 34 0.17 1ZZE-A nrPDB 34 0.22 4R1U-A nrPDB 34 0.23 3A28-C nrPDB 34 0.26 5ITV-A nrPDB 33 0.44 3PXX-A nrPDB 33 0.53 3WYE-A nrPDB 32 0.68 1GEG-A nrPDB 32 0.91 5U9C-A nrPDB 32 1.2 4K6F-A nrPDB 31 1.6 4AVY-A nrPDB 31 1.9 4KMS-A nrPDB 31 2.1 3VR3-A nrPDB 30 2.7 1KO7-A nrPDB 30 3.1 2AX4-A nrPDB 30 3.6 5XCC-A nrPDB 30 4.4 6GCS-E nrPDB 30 4.8 1YXM-A nrPDB 29 6.5 3S8M-A nrPDB 29 8.1 >1Z45-A nrPDB Length = 699 Score = 1450 bits (3754), Expect = 0.0, Method: Compositional matrix adjust. Identities = 698/699 (99%), Positives = 699/699 (100%) Query: 1 MTAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTK 60 MTAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTK Sbjct: 1 MTAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTK 60 Query: 61 HHIPFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLE 120 HHIPFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLE Sbjct: 61 HHIPFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLE 120 Query: 121 LMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNS 180 LMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNS Sbjct: 121 LMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNS 180 Query: 181 DKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSR 240 DKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSR Sbjct: 181 DKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSR 240 Query: 241 DGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASG 300 DGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASG Sbjct: 241 DGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASG 300 Query: 301 IDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQLRGV 360 IDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQLRGV Sbjct: 301 IDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQLRGV 360 Query: 361 EARFSAEDMRYDARFVTIGAGTRFQATFANLGASIVDLKVNGQSVVLGYENEEGYLNPDS 420 EARFSAEDMRYDARFVTIGAGTRFQATFANLGASIVDLKVNGQSVVLGYENEEGYLNPDS Sbjct: 361 EARFSAEDMRYDARFVTIGAGTRFQATFANLGASIVDLKVNGQSVVLGYENEEGYLNPDS 420 Query: 421 AYIGATIGRYANRISKGKFSLCNKDYQLTVNNGVNANHSSIGSFHRKRFLGPIIQNPSKD 480 AYIGATIGRYANRISKGKFSLCNKDYQLTVNNGVNANHSSIGSFHRKRFLGPIIQNPSKD Sbjct: 421 AYIGATIGRYANRISKGKFSLCNKDYQLTVNNGVNANHSSIGSFHRKRFLGPIIQNPSKD 480 Query: 481 VFTAEYMLIDNEKDTEFPGDLLVTIQYTVNVAQKSLEMVYKGKLTAGEATPINLTNHSYF 540 VFTAEYMLIDNEKDTEFPGDLLVTIQYTVNVAQKSLE+VYKGKLTAGEATPINLTNHSYF Sbjct: 481 VFTAEYMLIDNEKDTEFPGDLLVTIQYTVNVAQKSLEIVYKGKLTAGEATPINLTNHSYF 540 Query: 541 NLNKPYGDTIEGTEIMVRSKKSVDVDKNMIPTGNIVDREIATFNSTKPTVLGPKNPQFDC 600 NLNKPYGDTIEGTEIMVRSKKSVDVDKNMIPTGNIVDREIATFNSTKPTVLGPKNPQFDC Sbjct: 541 NLNKPYGDTIEGTEIMVRSKKSVDVDKNMIPTGNIVDREIATFNSTKPTVLGPKNPQFDC 600 Query: 601 CFVVDENAKPSQINTLNNELTLIVKAFHPDSNITLEVLSTEPTYQFYTGDFLSAGYEARQ 660 CFVVDENAKPSQINTLNNELTLIVKAFHPDSNITLEVLSTEPTYQFYTGDFLSAGYEARQ Sbjct: 601 CFVVDENAKPSQINTLNNELTLIVKAFHPDSNITLEVLSTEPTYQFYTGDFLSAGYEARQ 660 Query: 661 GFAIEPGRYIDAINQENWKDCVTLKNGETYGSKIVYRFS 699 GFAIEPGRYIDAINQENWKDCVTLKNGETYGSKIVYRFS Sbjct: 661 GFAIEPGRYIDAINQENWKDCVTLKNGETYGSKIVYRFS 699 >4LIS-A nrPDB Length = 371 Score = 429 bits (1103), Expect = e-120, Method: Compositional matrix adjust. Identities = 207/359 (57%), Positives = 259/359 (72%), Gaps = 16/359 (4%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 S VLVTGG GYIGS T + L+E GY VVADNL NS+ +++ R+E+++ F ++D+ Sbjct: 3 SGSVLVTGGTGYIGSFTTLALLEAGYKVVVADNLYNSSAEALNRIELISGKKAEFAQLDV 62 Query: 71 CDRKGLEKVFKEY-KIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSK 129 D +KVF+ + IDSVIHFA LKAVGES + PL YYH N+ GT+ LL M ++NV+ Sbjct: 63 TDEAAFDKVFEAHPDIDSVIHFAALKAVGESGEKPLDYYHVNVYGTICLLRSMVRHNVTN 122 Query: 130 FVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKS----- 184 VFSSSATVYGDATRFP+MIPIPE CPLGPTNPYG+TK+AIE + D+ N+ + + Sbjct: 123 IVFSSSATVYGDATRFPDMIPIPEHCPLGPTNPYGNTKFAIELAITDVINAQRNNAKKAG 182 Query: 185 -------WKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDY 237 W A+LRYFNP GAHPSG++GEDP G+P NLLP +AQVA G+REKL +FGDDY Sbjct: 183 NETEAAKWNGALLRYFNPAGAHPSGIMGEDPQGVPYNLLPLLAQVATGKREKLLVFGDDY 242 Query: 238 DSRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCK 297 S DGT IRDYIH++DLA GH+ AL YL A N R WNLG+G+GSTV+E+ AF K Sbjct: 243 ASHDGTAIRDYIHILDLADGHLKALNYLRANNPG---VRAWNLGTGRGSTVYEMIRAFSK 299 Query: 298 ASGIDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQ 356 A G DLPY+V RRAGDVLNLT+ P RA EL W+ + +E +C+DLW WT NP GY+ Sbjct: 300 AVGRDLPYEVAPRRAGDVLNLTSNPTRANTELGWKAQRTLEQACEDLWLWTKNNPQGYR 358 >1I3M-A nrPDB Length = 348 Score = 370 bits (949), Expect = e-102, Method: Compositional matrix adjust. Identities = 188/349 (53%), Positives = 242/349 (69%), Gaps = 16/349 (4%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSN------STYDSVARLEVLTKHHIPFYE 67 VLVTGGAGYIGSHTV+EL+E GY VV DN N S +S+ R++ LT + F E Sbjct: 5 VLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEE 64 Query: 68 VDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNV 127 +D+ D+ L+++FK+Y +VIHFAGLKA+GES Q PL YY N+ GT+ LLE+M+ + V Sbjct: 65 MDILDQGALQRLFKKYSFMAVIHFAGLKAMGESVQKPLDYYRVNLTGTIQLLEIMKAHGV 124 Query: 128 SKFVFSSSATVYGDATRFPNMIPIPEECPLGP-TNPYGHTKYAIENILNDLYNSDKKSWK 186 VFSSSATVYG+ P +P+ E P G TNPYG +K+ IE ++ DL +DK +W Sbjct: 125 KNLVFSSSATVYGN----PQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADK-TWN 179 Query: 187 FAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIR 246 +LRYFNP GAH SG IGEDP GIPNNL+PY++QVA+GRRE L +FG+DYD+ DGT +R Sbjct: 180 VVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVR 239 Query: 247 DYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYK 306 DYIHVVDLAKGHIAAL+ L+ E G CR +NLG+G G +V ++ A KASG +PYK Sbjct: 240 DYIHVVDLAKGHIAALRKLK---EQCG-CRIYNLGTGTGYSVLQMVQAMEKASGKKIPYK 295 Query: 307 VTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGY 355 V RR GDV A P A+ EL W L ++ C+DLW+W +NP G+ Sbjct: 296 VVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGF 344 >3ENK-A nrPDB Length = 341 Score = 360 bits (925), Expect = e-99, Method: Compositional matrix adjust. Identities = 184/349 (52%), Positives = 232/349 (66%), Gaps = 9/349 (2%) Query: 7 SESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFY 66 S ST +LVTGGAGYIGSHT VEL+ +GYD V+ADNL NS +++AR+E +T F+ Sbjct: 1 SMSTKGTILVTGGAGYIGSHTAVELLAHGYDVVIADNLVNSKREAIARIEKITGKTPAFH 60 Query: 67 EVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN 126 E D+ D + L ++F + I + IHFA LKAVGES P+ YY NN+ + LL +M++ Sbjct: 61 ETDVSDERALARIFDAHPITAAIHFAALKAVGESVAKPIEYYRNNLDSLLSLLRVMRERA 120 Query: 127 VSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWK 186 V + VFSSSATVYG P PI E PL TNPYG TK E IL D+ +D SW+ Sbjct: 121 VKRIVFSSSATVYG----VPERSPIDETFPLSATNPYGQTKLMAEQILRDVEAAD-PSWR 175 Query: 187 FAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIR 246 A LRYFNP+GAH SGLIGEDP GIPNNL+PY+AQVAVG+ EKL +FG DY + DGT +R Sbjct: 176 VATLRYFNPVGAHESGLIGEDPAGIPNNLMPYVAQVAVGKLEKLRVFGSDYPTPDGTGVR 235 Query: 247 DYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYK 306 DYIHVVDLA+GHIAAL LE + + + NLG+G+G +V EV AF KASG +PY+ Sbjct: 236 DYIHVVDLARGHIAALDALERRDASLTV----NLGTGRGYSVLEVVRAFEKASGRAVPYE 291 Query: 307 VTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGY 355 + RR GDV A P A + W+ E +E C D W+W NP G+ Sbjct: 292 LVARRPGDVAECYANPAAAAETIGWKAERDLERMCADHWRWQENNPRGF 340 >1UDA-A nrPDB Length = 338 Score = 336 bits (861), Expect = 3e-92, Method: Compositional matrix adjust. Identities = 169/343 (49%), Positives = 227/343 (66%), Gaps = 10/343 (2%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCDR 73 VLVTGG+GYIGSHT V+L++NG+D ++ DNL NS + +E L H F E D+ + Sbjct: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 Query: 74 KGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFVFS 133 + ++ ++ ID+VIHFAGLKAVGES Q PL YY NN+ GT+ L+ M+ NV F+FS Sbjct: 63 ALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFS 122 Query: 134 SSATVYGDATRFPNMIPIPEECPLG-PTNPYGHTKYAIENILNDLYNSDKKSWKFAILRY 192 SSATVYGD + IP E P G P +PYG +K +E IL DL + + W A+LRY Sbjct: 123 SSATVYGDNPK----IPYVESFPTGTPQSPYGKSKLMVEQILTDLQKA-QPDWSIALLRY 177 Query: 193 FNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYIHVV 252 FNP+GAHPSG +GEDP GIPNNL+PY+AQVAVGRR+ L IFG+DY + DGT +RDYIHV+ Sbjct: 178 FNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVM 237 Query: 253 DLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYKVTGRRA 312 DLA GH+ A++ L N+ +NLG+G G++V +V +AF KA G + Y RR Sbjct: 238 DLADGHVVAMEKL----ANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRRE 293 Query: 313 GDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGY 355 GD+ A +A REL W+ +++ +D W W + +P GY Sbjct: 294 GDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGY 336 >1YGA-A nrPDB Length = 342 Score = 335 bits (859), Expect = 4e-92, Method: Compositional matrix adjust. Identities = 171/329 (51%), Positives = 232/329 (70%), Gaps = 7/329 (2%) Query: 376 VTIGAGTRFQATFANLGASIVDLKVNGQSVVLGYENEEGYLNPDSAYIGATIGRYANRIS 435 +TIG +FQAT A LGA++VDLKVNGQSVV GY N + YL D +GAT+GRYANRI+ Sbjct: 13 ITIGDEKKFQATIAPLGATLVDLKVNGQSVVQGYSNVQDYLT-DGNMMGATVGRYANRIA 71 Query: 436 KGKFSLCNKDYQLTVNNGVNANHSSIGSFHRKRFLGPIIQNPSKDVFTAEYMLIDNEKD- 494 KG FSL + ++LTVNN N NHSSI S + K++ ++NPSK V+ E+ L+D+ Sbjct: 72 KGVFSLDDGPHKLTVNNCGNTNHSSISSLNLKQYKASPVENPSKGVYVVEFKLLDDHTQP 131 Query: 495 --TEFPGDLLVTIQYTVNVAQKSLEMVYKGKLTAGEATPINLTNHSYFNLNKPYGD-TIE 551 EFPGDL VT++YT+NVA+ +L+M Y+ +L G+ATPIN+TNHSYFNLNK + +I Sbjct: 132 NPNEFPGDLEVTVKYTLNVAEMTLDMEYQAQLVRGDATPINMTNHSYFNLNKVKSEKSIR 191 Query: 552 GTEIMVRSKKSVDVDKN-MIPTGNIVDREIATFNSTKPTVLGPKNPQFDCCFVVDENAKP 610 GTE+ V S KS++V + ++PTG I++R IATF+STKPTVL P FDC F++D N Sbjct: 192 GTEVKVCSNKSLEVTEGALLPTGKIIERNIATFDSTKPTVLHEDTPVFDCTFIIDANKDL 251 Query: 611 SQINTLN-NELTLIVKAFHPDSNITLEVLSTEPTYQFYTGDFLSAGYEARQGFAIEPGRY 669 ++++ N+L + KA+HP+S+I EV +TEPT YTGD L + R GFA++ GRY Sbjct: 252 KTTDSVSVNKLVPVFKAYHPESHIKFEVSTTEPTVHLYTGDNLCGKFVPRSGFAVQQGRY 311 Query: 670 IDAINQENWKDCVTLKNGETYGSKIVYRF 698 +DAIN++ W+ CV LK GE Y SK Y+F Sbjct: 312 VDAINRDEWRGCVLLKRGEVYTSKTQYKF 340 >2C20-A nrPDB Length = 330 Score = 251 bits (640), Expect = 1e-66, Method: Compositional matrix adjust. Identities = 141/344 (40%), Positives = 201/344 (58%), Gaps = 19/344 (5%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCDR 73 +L+ GGAGYIGSH V +L++ G VV DNL D++ FY DL D+ Sbjct: 4 ILICGGAGYIGSHAVKKLVDEGLSVVVVDNLQTGHEDAITE-------GAKFYNGDLRDK 56 Query: 74 KGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFVFS 133 L VF + I++V+HFA VG S + PL+YY+NN+ G + LLE+M ++ V KF+FS Sbjct: 57 AFLRDVFTQENIEAVMHFAADSLVGVSMEKPLQYYNNNVYGALCLLEVMDEFKVDKFIFS 116 Query: 134 SSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAILRYF 193 S+A YG+ ++ I EE PTN YG TK AIE +L+ + S + ++ I RYF Sbjct: 117 STAATYGEV----DVDLITEETMTNPTNTYGETKLAIEKMLH--WYSQASNLRYKIFRYF 170 Query: 194 NPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYIHVVD 253 N GA P+G+IGED +L+P + QVA+G+REK+ +FGDDY++ DGT IRDYIHV D Sbjct: 171 NVAGATPNGIIGEDHRP-ETHLIPLVLQVALGQREKIMMFGDDYNTPDGTCIRDYIHVED 229 Query: 254 LAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYKVTGRRAG 313 L H L+ L +N G +NLG+G G +V E+ A + + ++P +V RRAG Sbjct: 230 LVAAHFLGLKDL----QNGGESDFYNLGNGNGFSVKEIVDAVREVTNHEIPAEVAPRRAG 285 Query: 314 DVLNLTAKPDRAKRELKWQTE-LQVEDSCKDLWKWTTENPFGYQ 356 D L A +AK +L W + V+ + W W + P GY+ Sbjct: 286 DPARLVASSQKAKEKLGWDPRYVNVKTIIEHAWNWHQKQPNGYE 329 >4WOK-A nrPDB Length = 336 Score = 203 bits (516), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 131/348 (37%), Positives = 183/348 (52%), Gaps = 27/348 (7%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCDR 73 VLV GGAG+IGSHT L GY VV DNLS +V + F E D+ D+ Sbjct: 14 VLVVGGAGFIGSHTAKLLAGQGYAPVVYDNLSTGHQSAVRWGD--------FVEGDILDQ 65 Query: 74 KGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFVFS 133 L + ++Y +VIHFA VGES + P +YY NN+ GT LL+ + +FS Sbjct: 66 ARLVETMEKYAPVAVIHFAASAYVGESVEDPAKYYRNNVGGTQSLLDACRLTRTQNVIFS 125 Query: 134 SSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAILRYF 193 SS YG P+ +PI E P NPYG TK E++L D + ++ LRYF Sbjct: 126 SSCATYG----VPSRLPIGEGEAQNPINPYGRTKLIAEHMLADY--AVAYGLRYVALRYF 179 Query: 194 NPIGAHPSGLIGE--DPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYIHV 251 N GA G +GE DP +L+P A GR + L ++GDDY++ DGT IRDYIHV Sbjct: 180 NASGADIDGELGEKHDP---ETHLIPRAMMAAAGRLDVLEVYGDDYETPDGTCIRDYIHV 236 Query: 252 VDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYKVTGRR 311 DLA+ H+ A+++L+ N + NLG+G+G+++ E+ + + +G +P + RR Sbjct: 237 TDLARAHVLAVEHLKEAGGNLAV----NLGTGRGTSIREIVQSIGRLTGRSVPVAMRARR 292 Query: 312 AGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQLRG 359 AGD L A P A +L + T S D T FG ++RG Sbjct: 293 AGDPPALYADPALAAEKLGFHTVY----SDLDTIIRTAAPHFGLEVRG 336 >1GY8-A nrPDB Length = 397 Score = 187 bits (475), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 135/380 (35%), Positives = 193/380 (50%), Gaps = 40/380 (10%) Query: 14 VLVTGGAGYIGSHTVVELIEN-GYDCVVADNLSNS--------TYDSVARLEVLTKHHIP 64 VLV GGAGYIGSH V L+ + + V+ D+L + T ++VAR + P Sbjct: 5 VLVCGGAGYIGSHFVRALLRDTNHSVVIVDSLVGTHGKSDHVETRENVARKLQQSDGPKP 64 Query: 65 FY-------EV-DLCDRKGLEKVFKEY-KIDSVIHFAGLKAVGESTQIPLRYYHNNILGT 115 + EV D+ + L VF + ID+V+H AVGES + PL+YY NN++G Sbjct: 65 PWADRYAALEVGDVRNEDFLNGVFTRHGPIDAVVHMCAFLAVGESVRDPLKYYDNNVVGI 124 Query: 116 VVLLELMQQYNVSKFVFSSSATVYGDATR---FPNMIPIPEECPLGPTNPYGHTKYAIEN 172 + LL+ M + K +FSSSA ++G+ T N PI P +PYG +K E Sbjct: 125 LRLLQAMLLHKCDKIIFSSSAAIFGNPTMGSVSTNAEPIDINAKKSPESPYGESKLIAER 184 Query: 173 ILNDLYNSDKKSWKFAILRYFNPIGAHPSGLIGEDPLG----IPNNLLPYMAQVAVGRR- 227 ++ D ++ K LRYFN GAH G IGE G IP L M+ +A +R Sbjct: 185 MIRDC--AEAYGIKGICLRYFNACGAHEDGDIGEHYQGSTHLIPIILGRVMSDIAPDQRL 242 Query: 228 ---------EKLYIFGDDYDSRDGTPIRDYIHVVDLAKGHIAALQYLEAY--NENEGLCR 276 +++ IFG DY + DGT +RDY+HV DLA HI AL Y+E N+ Sbjct: 243 TIHEDASTDKRMPIFGTDYPTPDGTCVRDYVHVCDLASAHILALDYVEKLGPNDKSKYFS 302 Query: 277 EWNLGSGKGSTVFEVYHAFCKASGIDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQ 336 +NLG+ +G +V EV K +G +P + GRR GD L A D+A+ L W+ + Sbjct: 303 VFNLGTSRGYSVREVIEVARKTTGHPIPVRECGRREGDPAYLVAASDKAREVLGWKPKYD 362 Query: 337 -VEDSCKDLWKWTTENPFGY 355 +E + WK+ +P GY Sbjct: 363 TLEAIMETSWKFQRTHPNGY 382 >1SNZ-A nrPDB Length = 344 Score = 146 bits (369), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 101/319 (31%), Positives = 151/319 (47%), Gaps = 37/319 (11%) Query: 395 IVDLKVNGQSVVLGYENEEGYLNPDSAYIGATIGRYANRISKGKFSLCNKDYQLTVNNGV 454 + D + VVLG+ EGYL Y GA IGR ANRI+KG F + K+Y L +N Sbjct: 47 VKDRQGRASDVVLGFAELEGYLQ-KQPYFGAVIGRVANRIAKGTFKVDGKEYHLAINKEP 105 Query: 455 NANHSSIGSFHRKRFLGPIIQNPSKDVFTAEYMLIDNEKDTEFPGDLLVTIQYTVNVAQK 514 N+ H + F + + ++ N ++ I + + +PG+L V + YT++ Sbjct: 106 NSLHGGVRGFDKVLWTPRVLSN------GVQFSRISPDGEEGYPGELKVWVTYTLDGG-- 157 Query: 515 SLEMVYKGKLTAGEATPINLTNHSYFNLNKPYGDTIEGTEIMVRSKKSVDVDKNMIPTGN 574 E++ + A +ATP+NLTNHSYFNL I E+ + + + VD+ +IPTG Sbjct: 158 --ELIVNYRAQASQATPVNLTNHSYFNLAGQASPNINDHEVTIEADTYLPVDETLIPTGE 215 Query: 575 IVDREIATFNSTKPTVLGPKNPQ------FDCCFVVDENAKPSQINTLNNELTLIVKAFH 628 + + F+ KP LG K+ Q FD F + + E + H Sbjct: 216 VAPVQGTAFDLRKPVELG-KHLQDFHLNGFDHNFCLKG----------SKEKHFCARVHH 264 Query: 629 PDSNITLEVLSTEPTYQFYTGDFL--------SAGYEARQGFAIEPGRYIDAINQENWKD 680 S LEV +T+P QFYTG+FL A Y GF +E + DA+NQ + Sbjct: 265 AASGRVLEVYTTQPGVQFYTGNFLDGTLKGKNGAVYPKHSGFCLETQNWPDAVNQPRFPP 324 Query: 681 CVTLKNGETYGSKIVYRFS 699 V L+ GE Y ++FS Sbjct: 325 -VLLRPGEEYDHTTWFKFS 342 >1LUR-A nrPDB Length = 339 Score = 101 bits (252), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 94/342 (27%), Positives = 154/342 (45%), Gaps = 36/342 (10%) Query: 375 FVTIGAGTRFQATFANLGASIVDLKV---NG--QSVVLGYENEEGYLNPDSAYIGATIGR 429 F+ I AT GA++ L NG Q +VLG++ + + D+A IG T+GR Sbjct: 14 FIEIANKQGLTATLLPFGATLAKLTFPDKNGKNQDLVLGFDTIDEF-EKDAASIGKTVGR 72 Query: 430 YANRISKGKFSLCNKDYQLTVNNGVNANHSSIGSFHRKRFLGPIIQNPSKDVFTAEYMLI 489 ANRI K Y +T NNG + H +++ ++++ + V + + Sbjct: 73 VANRIKNSTLHFDGKQYTMTPNNGPHYLHGGPNGLGYRKW--EVVRHAPESV---SFSVR 127 Query: 490 DNEKDTEFPGDLLVTIQYTVNVAQKSLEMVYKGKLTAGEATPINLTNHSYFNLNKPYGDT 549 NE+D PGD + + YTVN +++ + T + LTNH+Y+NL+ DT Sbjct: 128 ANEQDDGLPGDAKIDVTYTVNDRN---QLIIEHHATCDTPGLLALTNHAYWNLDG--SDT 182 Query: 550 IEGTEIMVRSKKSVDVDKNMIPTGNI--VDREIATFNSTKPTVLGPKNPQ----FDCCFV 603 + + + + + V+VD PTG I V F S K K+ + D V Sbjct: 183 VAEHFLEMEADEFVEVDDTFCPTGAIRSVTDTGFDFRSGKQLKESGKDAEELLDLDNDLV 242 Query: 604 VDENAKPSQINTLNNELTLIVKAFHPDSNITLEVLSTEPTYQFYTGDFLSAG------YE 657 + + PS +T ++ + S I L + ++ P Y FL Y+ Sbjct: 243 ITKKTPPSTPSTY-------LRFWSEKSGIELSITTSYPVIHLYASKFLDCKGKKGEHYK 295 Query: 658 ARQGFAIEPGRYIDAINQENWKDCVTLKNGETYGSKIVYRFS 699 A + AIEP + A N +++ D V+L+ G+ Y +IVY FS Sbjct: 296 ANKALAIEPQFHSAAPNFDHFPD-VSLRPGDHYCQEIVYTFS 336 >6BI4-A nrPDB Length = 346 Score = 99.0 bits (245), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 99/358 (27%), Positives = 162/358 (45%), Gaps = 43/358 (12%) Query: 2 TAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKH 61 T L +S + +LVTGGAG+IGS+ V ++++ Y+ N TY + Sbjct: 15 TENLYFQSNAMNILVTGGAGFIGSNFVHYMLQS-YETYKIINFDALTYSGNLNNVKSIQD 73 Query: 62 HIPFYEV--DLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLL 119 H +Y V ++ + + LE V KE + +++FA V S + P+ +Y N++GTV LL Sbjct: 74 HPNYYFVKGEIQNGELLEHVIKERDVQVIVNFAAESHVDRSIENPIPFYDTNVIGTVTLL 133 Query: 120 ELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYN 179 EL+++Y K V S+ VYG + EE PL P +PY +K + + I Y Sbjct: 134 ELVKKYPHIKLVQVSTDEVYGSLGKTGRFT---EETPLAPNSPYSSSKASADMIALAYY- 189 Query: 180 SDKKSWKFAIL--RYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDY 237 K+++ ++ R N G P P L+P M A+ +KL ++G Sbjct: 190 ---KTYQLPVIVTRCSNNYG----------PYQYPEKLIPLMVTNAL-EGKKLPLYG--- 232 Query: 238 DSRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCRE-WNLGSGKGSTVFEVYHAFC 296 DG +RD++HV D H +A+ + ++G E +N+G T EV Sbjct: 233 ---DGLNVRDWLHVTD----HCSAIDVV----LHKGRVGEVYNIGGNNEKTNVEVVEQII 281 Query: 297 KASG---IDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTEN 351 G D+ Y VT R D ++ K E W+ + E ++ +W +N Sbjct: 282 TLLGKTKKDIEY-VTDRLGHD-RRYAINAEKMKNEFDWEPKYTFEQGLQETVQWYEKN 337 >4RNL-A nrPDB Length = 343 Score = 98.2 bits (243), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 85/311 (27%), Positives = 135/311 (43%), Gaps = 36/311 (11%) Query: 400 VNGQSVVLGYENEEGYLNPDSAYIGATIGRYANRISKGKFSLCNKDYQLTVNNGVNANHS 459 + GQ + LG+ + Y +Y GA +GRYANRI+ F L + LT NNG ++ H Sbjct: 56 MRGQ-LALGFADLASYAAHGGSYFGALVGRYANRIAGASFVLDGRTDALTPNNGRHSLHG 114 Query: 460 SIGSFHRKRFLGPIIQNPSKDVFTAEYMLIDNEKDTEFPGDLLVTIQYTVNVAQKSLEMV 519 G F R ++ + + + + + + FPG L V + YT++ +L +V Sbjct: 115 GPGGFSR------VVWDAREVDGGVQLHRVSPDGEEGFPGALDVRVTYTLSAG--ALRIV 166 Query: 520 YKGKLTAGEATPINLTNHSYFNLNKPYGDTIEGTEIMVRSKKSVDVDKNMIPTGNIVDRE 579 A T +NLTNH+Y NL + G E+ + + + VD IP Sbjct: 167 SCATTDA--PTVVNLTNHTYLNLGGDGSGSAAGHELRLAASRYTPVDGTGIPVPGAPAEV 224 Query: 580 IAT---FNSTKPTVLGPKNPQFDCCFVVDENAKPSQINTLNNELTLIVKAFHPDSNITLE 636 T F + + V G +D F +D + + + + + P S L Sbjct: 225 TGTRFDFRAAR-AVAG----AYDHNFALDGGVREAPRT--------VAELYDPRSGRALA 271 Query: 637 VLSTEPTYQFYTGDFLSAG--------YEARQGFAIEPGRYIDAINQENWKDCVTLKNGE 688 + +TEP Q YT D L Y G A+E + D+ N+ ++ V L+ GE Sbjct: 272 LATTEPGLQLYTADHLDGTLTGTSGVPYGPAAGLALETQHFPDSPNRPDFPSTV-LRPGE 330 Query: 689 TYGSKIVYRFS 699 +Y S+ VY FS Sbjct: 331 SYRSETVYAFS 341 >6BWL-A nrPDB Length = 328 Score = 87.4 bits (215), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 89/339 (26%), Positives = 148/339 (43%), Gaps = 38/339 (11%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEV---DL 70 +LVTGGAG+IG V L+++ ++ + DNL+NST ++ H + + D+ Sbjct: 3 ILVTGGAGFIGRWVVKRLLQDKHEVWILDNLANSTTANITEF----AHDLNLKQCIQGDI 58 Query: 71 CDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKF 130 D+K + ++F+ D H A V +S + N+ +GT LLE Y+V K Sbjct: 59 KDKKLVAQLFENNSFDLCYHLAASINVQDSIDDARATFENDTIGTFNLLEQCLNYDV-KM 117 Query: 131 VFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAIL 190 VF S+ VY AT N+ I E P+ P +PY +K A EN++ Y + K ++ Sbjct: 118 VFMSTCMVYDKAT---NIQGISELDPIKPASPYAGSKIAAENMVLSYYYAYK--LPVVVI 172 Query: 191 RYFNPIG--AHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDY 248 R FN G G G + I N L L I+G DG RD Sbjct: 173 RPFNTYGPFQKTGGEGGVVAIFINNKL----------DNVPLNIYG------DGKQTRDL 216 Query: 249 IHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYKVT 308 ++V D A +AA +A N G+G+ ++ ++ + + + + Sbjct: 217 LYVEDCADFVVAAGYSAKANG------HIINAGTGQDISINKLAE-LISGNKVSIQHVTH 269 Query: 309 GRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKW 347 ++ L ++AK L W+ ++ +ED +W Sbjct: 270 IHPQSEIQKLLCNYEKAKTILNWEPKVSLEDGVIKTEEW 308 >1BXK-A nrPDB Length = 355 Score = 87.4 bits (215), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 70/253 (27%), Positives = 113/253 (44%), Gaps = 30/253 (11%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCDR 73 +L+TGGAG+IGS V +I D VV + + ++ V F +VD+CDR Sbjct: 4 ILITGGAGFIGSALVRYIINETSDAVVVVDKLTYAGNLMSLAPVAQSERFAFEKVDICDR 63 Query: 74 KGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQY-------- 125 L +VF E++ D V+H A V S P + NI+GT LLE + Y Sbjct: 64 AELARVFTEHQPDCVMHLAAESHVDRSIDGPAAFIETNIVGTYTLLEAARAYWNALTEDK 123 Query: 126 -NVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKS 184 + +F S+ VYGD + E P P++PY +K + ++++ ++ Sbjct: 124 KSAFRFHHISTDEVYGDLHSTDDF--FTETTPYAPSSPYSASKASSDHLV--------RA 173 Query: 185 WKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTP 244 W LR + + P P L+P M A+ + L ++G +G Sbjct: 174 W----LRTYGLPTLITNCSNNYGPYHFPEKLIPLMILNALAGK-SLPVYG------NGQQ 222 Query: 245 IRDYIHVVDLAKG 257 IRD+++V D A+ Sbjct: 223 IRDWLYVEDHARA 235 >1KEU-A nrPDB Length = 361 Score = 86.3 bits (212), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 97/367 (26%), Positives = 152/367 (41%), Gaps = 61/367 (16%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLT----KHHIPFYEVD 69 +L+TGGAG+IGS V +I+N D VV N+ TY LE L+ + F D Sbjct: 3 ILITGGAGFIGSAVVRHIIKNTQDTVV--NIDKLTY--AGNLESLSDISESNRYNFEHAD 58 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQY---- 125 +CD + ++F++Y+ D+V+H A V S P + NI+GT LLE+ ++Y Sbjct: 59 ICDSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYALLEVARKYWSAL 118 Query: 126 -----NVSKFVFSSSATVYGD---ATRFPNMIPIP---EECPLGPTNPYGHTKYAIENIL 174 N +F S+ VYGD N + +P E P++PY +K + ++++ Sbjct: 119 GEDKKNNFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDHLV 178 Query: 175 NDLYNSDKKSWKFAILRYFNP-IGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIF 233 ++W+ Y P I + S G P P L+P + A+ + L I+ Sbjct: 179 --------RAWRRT---YGLPTIVTNCSNNYG--PYHFPEKLIPLVILNAL-EGKPLPIY 224 Query: 234 GDDYDSRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCRE-WNLGSGKGSTVFEVY 292 G G IRD+++V D H AL + EG E +N+G +V Sbjct: 225 G------KGDQIRDWLYVED----HARALHMVVT----EGKAGETYNIGGHNEKKNLDVV 270 Query: 293 HAFC--------KASGIDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDL 344 C KA+ R G + REL W+ E + Sbjct: 271 FTICDLLDEIVPKATSYREQITYVADRPGHDRRYAIDAGKISRELGWKPLETFESGIRKT 330 Query: 345 WKWTTEN 351 +W N Sbjct: 331 VEWYLAN 337 >1L7J-A nrPDB Length = 347 Score = 82.4 bits (202), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 89/342 (26%), Positives = 153/342 (44%), Gaps = 61/342 (17%) Query: 387 TFANLGASIVDLKVNGQSVVLGYENEEGYLNPDSAYIGATIGRYANRISKGKFSLCNKDY 446 +F NLGA IVD + +G+ ++LG+++ + YL D AY GAT+G A RI G + KDY Sbjct: 26 SFTNLGARIVDWQKDGKHLILGFDSAKEYLEKD-AYPGATVGPTAGRIKDGLVKISGKDY 84 Query: 447 QLTVNNGVNANHSSIGSFHRKRF------LGPIIQNPSKDVFTAEYMLIDNEKDTEFPGD 500 L N G H S H K + LG +Q ++ L+ N+ +PG Sbjct: 85 ILNQNEGPQTLHGGEESIHTKLWTYEVTDLGAEVQ--------VKFSLVSNDGTNGYPGK 136 Query: 501 LLVTIQYTVNVAQKSLEMVYKGKLTAGEATPINLTNHSYFNLNKPYGDTIEGTEIMVRSK 560 + +++ ++ + K ++ Y+ + + T N T H YFNLN +++E + + + Sbjct: 137 IEMSVTHSFDDDNK-WKIHYEA--ISDKDTVFNPTGHVYFNLNGDASESVENHGLRLAAS 193 Query: 561 KSVDV-DKNMIPTGNIVD-----------REIA-TFNSTKPTVLGPKNPQFDCCFVVDEN 607 + V + D+ I G+IVD ++++ FNS V K D F++D+ Sbjct: 194 RFVPLKDQTEIVRGDIVDIKNTDLDFRQEKQLSNAFNSNMEQVQLVKG--IDHPFLLDQL 251 Query: 608 AKPSQINTLNNELTLIVKAFHPDSNITLEVLSTEPTYQFYTGDFLSAG---YEARQ---- 660 ++ LTL + ++ V + +P+ +T +F G +E +Q Sbjct: 252 G----LDKEQARLTL--------DDTSISVFTDQPSIVIFTANFGDLGTLYHEKKQVHHG 299 Query: 661 GFAIE----PGRYIDAINQENWKDCVTLKNGETYGSKIVYRF 698 G E PG Q ++LK GE Y + +Y Sbjct: 300 GITFECQVSPGS-----EQIPELGDISLKAGEKYQATTIYSL 336 >3RUE-A nrPDB Length = 351 Score = 79.0 bits (193), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 91/345 (26%), Positives = 149/345 (43%), Gaps = 35/345 (10%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTK----HHIPFYE 67 K L+TG AG+IGS+ + +L++ + DN S ++ ++ L F E Sbjct: 26 KTWLITGVAGFIGSNLLEKLLKLNQVVIGLDNFSTGHQYNLDEVKTLVSTEQWSRFCFIE 85 Query: 68 VDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNV 127 D+ D E+V K +D V+H A L +V S P+ NI G + +L + V Sbjct: 86 GDIRDLTTCEQVMK--GVDHVLHQAALGSVPRSIVDPITTNATNITGFLNILHAAKNAQV 143 Query: 128 SKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKF 187 F +++S++ YGD P + EE P +PY TKY + I +Y + +K Sbjct: 144 QSFTYAASSSTYGDHPALPKV----EENIGNPLSPYAVTKY-VNEIYAQVY-ARTYGFKT 197 Query: 188 AILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRD 247 LRYFN G +DP G ++P A+ + + +YI GD SRD I + Sbjct: 198 IGLRYFNVFGRR------QDPNGAYAAVIPKWT-AAMLKGDDVYINGDGETSRDFCYIDN 250 Query: 248 YIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFE----VYHAFCKASGID- 302 I + L A ++ +N+ G +T+ E +Y ID Sbjct: 251 VIQ-----------MNILSALAKDSAKDNIYNVAVGDRTTLNELSGYIYDELNLIHHIDK 299 Query: 303 LPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKW 347 L K R+GDV + A +A LK++ +++ + + W Sbjct: 300 LSIKYREFRSGDVRHSQADVTKAIDLLKYRPNIKIREGLRLSMPW 344 >2HUN-A nrPDB Length = 336 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 90/351 (25%), Positives = 161/351 (45%), Gaps = 45/351 (12%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDS-VARLEVLTKH-HIPFYEVDLC 71 +LVTGG G+IGS+ + ++E D V N+ Y S A L+ L F + D+ Sbjct: 6 LLVTGGMGFIGSNFIRYILEKHPDWEVI-NIDKLGYGSNPANLKDLEDDPRYTFVKGDVA 64 Query: 72 DRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVS-KF 130 D + ++++ + K+D V+H A V S P + H+N++GT LLE +++ N +F Sbjct: 65 DYELVKELVR--KVDGVVHLAAESHVDRSISSPEIFLHSNVIGTYTLLESIRRENPEVRF 122 Query: 131 VFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENIL---NDLYNSDKKSWKF 187 V S+ VYGD + E L P++PY TK A + ++ YN + Sbjct: 123 VHVSTDEVYGDILKG----SFTENDRLMPSSPYSATKAASDMLVLGWTRTYNLNA----- 173 Query: 188 AILRYFNPIGAHPSGLIGEDPLGIPNNLLP-YMAQVAVGRREKLYIFGDDYDSRDGTPIR 246 +I R N G P P L+P + + ++G K+ I+G G +R Sbjct: 174 SITRCTNNYG----------PYQFPEKLIPKTIIRASLGL--KIPIYG------TGKNVR 215 Query: 247 DYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGI-DLPY 305 D+++V D H+ A++ + E+ + +N+ +G+ T EV + G + Sbjct: 216 DWLYVED----HVRAIELVLLKGESREI---YNISAGEEKTNLEVVKIILRLMGKGEELI 268 Query: 306 KVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQ 356 ++ R G L + + R+LKW+ + ++ K W +N + ++ Sbjct: 269 ELVEDRPGHDLRYSLDSWKITRDLKWRPKYTFDEGIKKTIDWYLKNEWWWK 319 >1ORR-A nrPDB Length = 347 Score = 73.6 bits (179), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 83/361 (22%), Positives = 147/361 (40%), Gaps = 50/361 (13%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLS-NSTYDSVARLEVLTKHHIPFYEVDLCD 72 +L+TGG G++GS+ + G D +V DNLS D++ L L + F D+ + Sbjct: 4 LLITGGCGFLGSNLASFALSQGIDLIVFDNLSRKGATDNLHWLSSLG--NFEFVHGDIRN 61 Query: 73 RKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVS-KFV 131 + + ++ +Y DS H AG A+ S P + N+ GT+ LLE ++QYN + + Sbjct: 62 KNDVTRLITKYMPDSCFHLAGQVAMTTSIDNPCMDFEINVGGTLNLLEAVRQYNSNCNII 121 Query: 132 FSSSATVYGDATRFP--------NMIPIP----EECPLGPTNPYGHTKYAIENILNDLYN 179 +SS+ VYGD ++ + P E L +PYG +K A + + D Sbjct: 122 YSSTNKVYGDLEQYKYNETETRYTCVDKPNGYDESTQLDFHSPYGCSKGAADQYMLD--- 178 Query: 180 SDKKSWKFAILRYFNPIGAHPSGLIGEDPLGI-PNNLLPYMAQVAV----GRREKLYIFG 234 +A + N + S + G + + Q AV G + I G Sbjct: 179 -------YARIFGLNTVVFRHSSMYGGRQFATYDQGWVGWFCQKAVEIKNGINKPFTISG 231 Query: 235 DDYDSRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGS-----GKGSTVF 289 +G +RD +H D+ + AL + N +N+G +F Sbjct: 232 ------NGKQVRDVLHAEDMISLYFTALANVSKIRGN-----AFNIGGTIVNSLSLLELF 280 Query: 290 EVYHAFCKASGIDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTT 349 ++ +C ID+ + R D A + + W ++ +D + ++ WT+ Sbjct: 281 KLLEDYCN---IDMRFTNLPVRESDQRVFVADIKKITNAIDWSPKVSAKDGVQKMYDWTS 337 Query: 350 E 350 Sbjct: 338 S 338 >2Q1T-A nrPDB Length = 377 Score = 71.2 bits (173), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 88/357 (24%), Positives = 151/357 (42%), Gaps = 53/357 (14%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCV-VADNLSNSTYDSVARLEVLTKHHIPFYEVDLCD 72 V+V GGAG++GS+ V L+E G + V V DNL S ++ V + F E + D Sbjct: 35 VMVVGGAGFVGSNLVKRLLELGVNQVHVVDNLL-----SAEKINVPDHPAVRFSETSITD 89 Query: 73 RKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN-VSKFV 131 L + EY D V H A S PL + NN L T+ L E ++ + + K V Sbjct: 90 DALLASLQDEY--DYVFHLATYHGNQSSIHDPLADHENNTLTTLKLYERLKHFKRLKKVV 147 Query: 132 FSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYN---SDKKSWKFA 188 +S++ + T F + E + N + Y++ I + Y+ + Sbjct: 148 YSAAGCSIAEKT-FDDAKATEETDIVSLHN--NDSPYSMSKIFGEFYSVYYHKQHQLPTV 204 Query: 189 ILRYFNPIGAHPSGLIGE-----DPLGIPNNLLP-YMAQVAVGRREKLYIFGDDYDSRDG 242 R+ N G P ++G P + N+ P ++ + G L G Sbjct: 205 RARFQNVYG--PGEILGAGRWRGTPATVWRNVTPTFIYKALKGMPLPL--------ENGG 254 Query: 243 TPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGID 302 RD+I V D+A G IA A + G +N+ SGK +++ ++ + +G + Sbjct: 255 VATRDFIFVEDVANGLIAC-----AADGTPGGV--YNIASGKETSIADLATKINEITGNN 307 Query: 303 L--------PYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTEN 351 P+ +G+R G P++A+REL + ++ ++D + +WT N Sbjct: 308 TELDRLPKRPWDNSGKRFG-------SPEKARRELGFSADVSIDDGLRKTIEWTKAN 357 >1OC2-A nrPDB Length = 348 Score = 68.6 bits (166), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 90/366 (24%), Positives = 146/366 (39%), Gaps = 65/366 (17%) Query: 9 STSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTY-DSVARLEVLTKHHIPFYE 67 S K ++VTGGAG+IGS+ V + N + V L TY + A LE + + Sbjct: 2 SQFKNIIVTGGAGFIGSN-FVHYVYNNHPDVHVTVLDKLTYAGNKANLEAILGDRVELVV 60 Query: 68 VDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNV 127 D+ D + ++K+ K D+++H+A S P + H N +GT LLE ++Y++ Sbjct: 61 GDIADAELVDKLAA--KADAIVHYAAESHNDNSLNDPSPFIHTNFIGTYTLLEAARKYDI 118 Query: 128 SKFVFSSSATVYGDATRFPNMIPIPEECP---------------LGPTNPYGHTKYAIEN 172 +F S+ VYGD +P+ E+ P P++PY TK A + Sbjct: 119 -RFHHVSTDEVYGD-------LPLREDLPGHGEGPGEKFTAETNYNPSSPYSSTKAASDL 170 Query: 173 ILNDLYNSDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLP-YMAQVAVGRREKLY 231 I+ K+W +R F + P +P + + G + KLY Sbjct: 171 IV--------KAW----VRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILAGIKPKLY 218 Query: 232 IFGDDYDSRDGTPIRDYIHVVDLAKGHIAAL-------QYLEAYNENEGLCREWNLGSGK 284 +G +RD+IH D + G A L YL + + L K Sbjct: 219 --------GEGKNVRDWIHTNDHSTGVWAILTKGRMGETYLIGADGEKNNKEVLELILEK 270 Query: 285 GSTVFEVYHAFCKASGIDLPYKVTGRRAGDVLNLTAK----PDRAKRELKWQTELQVEDS 340 + Y +G DL Y + + D L T + + + ++W T+ Q Sbjct: 271 MGQPKDAYDHVTDRAGHDLRYAIDASKLRDELGWTPQFTDFSEGLEETIQWYTDNQ---- 326 Query: 341 CKDLWK 346 D WK Sbjct: 327 --DWWK 330 >2PZM-A nrPDB Length = 330 Score = 67.8 bits (164), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 81/342 (23%), Positives = 138/342 (40%), Gaps = 60/342 (17%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYD---SVARLEVLTKHHIPFYEVDL 70 +L+TGGAG +GS+ + + G++ +V DN + + VA L V+ E + Sbjct: 23 ILITGGAGCLGSNLIEHWLPQGHEILVIDNFATGKREVLPPVAGLSVI--------EGSV 74 Query: 71 CDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHN---NILGTVVLLELMQQYNV 127 D LE+ F +K V+H A + + P + + N+ G++ + + + V Sbjct: 75 TDAGLLERAFDSFKPTHVVHSAA------AYKDPDDWAEDAATNVQGSINVAKAASKAGV 128 Query: 128 SKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKF 187 + + +A YG P +PIP + P P YG +K A E L SD Sbjct: 129 KRLLNFQTALCYGR----PATVPIPIDSPTAPFTSYGISKTAGEAF---LMMSDV---PV 178 Query: 188 AILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRD 247 LR N G P IG P + ++ G++ F D +RD Sbjct: 179 VSLRLANVTG--PRLAIGPIPT--------FYKRLKAGQK----CFCSDT-------VRD 217 Query: 248 YIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDL--PY 305 ++ + D IA L E +N+ +G+G ++ EV+ G L P Sbjct: 218 FLDMSDFLA--IADLSLQEGRPTG-----VFNVSTGEGHSIKEVFDVVLDYVGATLAEPV 270 Query: 306 KVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKW 347 V A DV ++ P + + E W+ ++ +D+ W Sbjct: 271 PVVAPGADDVPSVVLDPSKTETEFGWKAKVDFKDTITGQLAW 312 >1R66-A nrPDB Length = 337 Score = 67.8 bits (164), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 91/350 (26%), Positives = 138/350 (39%), Gaps = 50/350 (14%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADN---LSNSTY--DSVARLEVLTKHHIPFYEV 68 +LVTGGAG+IGSH V +L+ Y V AD L + TY + V + F Sbjct: 3 LLVTGGAGFIGSHFVRQLLAGAYPDVPADEVIVLDSLTYAGNRANLAPVDADPRLRFVHG 62 Query: 69 DLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVS 128 D+ D L + + +D+++HFA V S + N+ GT LL+ V Sbjct: 63 DIRDAGLLARELR--GVDAIVHFAAESHVDRSIAGASVFTETNVQGTQTLLQCAVDAGVG 120 Query: 129 KFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYA---IENILNDLYNSDKKSW 185 + V S+ VYG + E PL P +PY +K + + Y D + Sbjct: 121 RVVHVSTDEVYGSI----DSGSWTESSPLEPNSPYAASKAGSDLVARAYHRTYGLDVR-- 174 Query: 186 KFAILRYFNPIG--AHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGT 243 I R N G HP LI PL + N L L ++G DG Sbjct: 175 ---ITRCCNNYGPYQHPEKLI---PLFVTNLL----------DGGTLPLYG------DGA 212 Query: 244 PIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDL 303 +R+++H D +G L A +++G G T E+ + G D Sbjct: 213 NVREWVHTDDHCRGIALVLAGGRA-------GEIYHIGGGLELTNRELTGILLDSLGADW 265 Query: 304 P--YKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTEN 351 KV R+ D L + + +REL ++ ++ D +W EN Sbjct: 266 SSVRKVADRKGHD-LRYSLDGGKIERELGYRPQVSFADGLARTVRWYREN 314 >3IMH-A nrPDB Length = 338 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 52/206 (25%), Positives = 101/206 (49%), Gaps = 17/206 (8%) Query: 390 NLGASIVDLKVNGQSVVLGYENEEGYLNPDSAYIGATIGRYANRISKGKFSLCNKDYQLT 449 N GA++ + ++G++++L + E Y + + ++G T+GR A R+ G++ N+ +QL Sbjct: 35 NYGATLEKVLLDGENMILSLNSPEDY-SKERNFLGGTVGRIAGRVRAGQWKHGNEIHQLP 93 Query: 450 VNNGVNANHSSIGS-FHRKRFLGPIIQNPSKDVFTA--EYMLIDNEKDTEFPGDLLVTIQ 506 +N+G N H IG+ H F PS D A + L D + + ++PG+L + + Sbjct: 94 LNDGDNHIHGGIGTDMHVWDF------RPSCDSEHARVDLTLFDPDGNNDYPGNLKLHAR 147 Query: 507 YTVNVAQKSLEMVYKGKLTAGEATPINLTNHSYFNLNKPYGDTIEGTEIMVRSKKSVDVD 566 Y ++ + Y + + + T N NH+YFNL G+ E + + + + VD Sbjct: 148 YELDNENN---LHYLLEAVSDKLTIFNPVNHTYFNL----GERAEDLNLQMNADYYLPVD 200 Query: 567 KNMIPTGNIVDREIATFNSTKPTVLG 592 + +P + + F+ K +G Sbjct: 201 EAGLPDRGMAEVAGTAFDFRKTKRIG 226 >1WVG-A nrPDB Length = 359 Score = 62.8 bits (151), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 91/352 (25%), Positives = 138/352 (39%), Gaps = 45/352 (12%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDS---VARLEVLTKHHIPFYEV 68 K V VTG G+ GS + L E G V L T S + RL L + HI Sbjct: 10 KRVFVTGHTGFKGSWLSLWLTEMG-AIVKGYALDAPTVPSLFEIVRLNDLMESHIG---- 64 Query: 69 DLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQY-NV 127 D+ D + L E+K + V H A V S + P++ Y N++GTV LLE ++Q N+ Sbjct: 65 DIRDFEKLRSSIAEFKPEIVFHMAAQPLVRLSYEQPIKTYSTNVMGTVHLLETVKQVGNI 124 Query: 128 SKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNS------- 180 V +S Y + + E P+G +PY ++K E + + NS Sbjct: 125 KAVVNITSDKCYDNREW---VWGYRENEPMGGYDPYSNSKGCAELVASAFRNSFFNPANY 181 Query: 181 DKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYM--AQVAVGRREKLYIFGDDYD 238 ++ A +R N IG G +D L IP+ L + QV + Sbjct: 182 EQHGVGLASVRAGNVIGG---GDWAKDRL-IPDILRSFENNQQVII-------------- 223 Query: 239 SRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLG--SGKGSTVFEVYHAFC 296 R+ IR + HV++ G+I Q L Y E WN G TV + Sbjct: 224 -RNPYSIRPWQHVLEPLSGYIVVAQRL--YTEGAKFSEGWNFGPRDEDAKTVEFIVDKMV 280 Query: 297 KASGIDLPYKVTGR-RAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKW 347 G D + + G + L +A +L W + ++ + KW Sbjct: 281 TLWGDDASWLLDGENHPHEAHYLKLDCSKANMQLGWHPRWGLTETLSRIVKW 332 >2PK3-A nrPDB Length = 321 Score = 62.8 bits (151), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 75/333 (22%), Positives = 139/333 (41%), Gaps = 43/333 (12%) Query: 15 LVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCDRK 74 L+TG AG++G + L E + ++ ++ A+L ++ +D+ D + Sbjct: 16 LITGVAGFVGKYLANHLTEQNVEVF------GTSRNNEAKLP-----NVEMISLDIMDSQ 64 Query: 75 GLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFVFS- 133 ++KV + K D + H A +V +S + N+ GT+ +L+ ++ N+ + + Sbjct: 65 RVKKVISDIKPDYIFHLAAKSSVKDSWLNKKGTFSTNVFGTLHVLDAVRDSNLDCRILTI 124 Query: 134 SSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAIL--R 191 S+ YG P P+ EE L P +PYG +K ++ +L Y K++ I+ R Sbjct: 125 GSSEEYG--MILPEESPVSEENQLRPMSPYGVSKASV-GMLARQY---VKAYGMDIIHTR 178 Query: 192 YFNPIGAHPS-GLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYIH 250 FN IG S G + +D + + + ++E + G+ RD T +RD + Sbjct: 179 TFNHIGPGQSLGFVTQD-------FAKQIVDIEMEKQEPIIKVGNLEAVRDFTDVRDIVQ 231 Query: 251 VVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASG--IDLPYKVT 308 A L Y + + +N+ SG G+ + +V + ID Sbjct: 232 ----------AYWLLSQYGKTGDV---YNVCSGIGTRIQDVLDLLLAMANVKIDTELNPL 278 Query: 309 GRRAGDVLNLTAKPDRAKRELKWQTELQVEDSC 341 R +V L R K W+ + +E S Sbjct: 279 QLRPSEVPTLIGSNKRLKDSTGWKPRIPLEKSL 311 >4EJ0-A nrPDB Length = 342 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 72/281 (25%), Positives = 126/281 (44%), Gaps = 45/281 (16%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVA-DNLSNSTYDSVARLEVLTKHHIPFYEVDLCD 72 ++VTG AG+IG++ V L E G ++A DNL+ + + + L I D D Sbjct: 15 LIVTGAAGFIGANLVKALNERGETRIIAVDNLTRAD-----KFKNLVDCEID----DYLD 65 Query: 73 RKGLEKVFKE---YKIDSVIHFAGLKAVGESTQIPLRYYHNNIL--GTVVLLELMQQYNV 127 + + F K+ +V H A ++ + RY +N VL + Q Sbjct: 66 KTEFVERFARGDFGKVRAVFHEG---ACSDTMETDGRYMMDNNFRYSRAVLDACLAQ--G 120 Query: 128 SKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKF 187 ++F+++SSA +YG ++RF + E P N YG++K+ + ++ + K + Sbjct: 121 AQFLYASSAAIYGGSSRF-----VEEREVEAPLNVYGYSKFLFDQVIRRVMPGAKS--QI 173 Query: 188 AILRYFNPIGAHPS--GLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPI 245 A RYFN G S G + +N + A+ K+ +FG+ G Sbjct: 174 AGFRYFNVYGPRESHKGRMASVAF---HNFNQFRAE------GKVKLFGEYSGYGPGEQT 224 Query: 246 RDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGS 286 RD++ V D+AK ++ Y + E G+ +NLG+G+ Sbjct: 225 RDFVSVEDVAKVNL----YFFDHPEKSGI---FNLGTGRAQ 258 >1GFS-A nrPDB Length = 321 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 71/307 (23%), Positives = 122/307 (39%), Gaps = 51/307 (16%) Query: 67 EVDLCDRKGLEKVFKEYKIDSV-IHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQY 125 E++L D + + F +ID V + A + + + P + + N++ ++ Q Sbjct: 38 ELNLLDSRAVHDFFASERIDQVYLAAAKVGGIVANNTYPADFIYQNMMIESNIIHAAHQN 97 Query: 126 NVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTN-PYGHTKYA---IENILNDLYNSD 181 +V+K +F S+ +Y + P + L PTN PY K A + N Y D Sbjct: 98 DVNKLLFLGSSCIYPKLAKQPMAESELLQGTLEPTNEPYAIAKIAGIKLCESYNRQYGRD 157 Query: 182 KKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNN------LLPYMAQVAVGRREKLYIFGD 235 +S P+ L G P+N LL + + ++G Sbjct: 158 YRS-------------VMPTNLYGPHDNFHPSNSHVIPALLRRFHEATAQNAPDVVVWGS 204 Query: 236 DYDSRDGTPIRDYIHVVDLAKGHIAALQYL-EAYNEN-EGLCREWNLGSGKGSTVFEVYH 293 GTP+R+++HV D+A I ++ E + EN + + N+G+G T+ E+ Sbjct: 205 ------GTPMREFLHVDDMAAASIHVMELAHEVWLENTQPMLSHINVGTGVDCTIRELAQ 258 Query: 294 AFCKASGIDLPYKVTGRRAGDVLNLTAKPDRAKR---------ELKWQTELQVEDSCKDL 344 K G YK G V+ +KPD R +L W E+ +E Sbjct: 259 TIAKVVG----YK------GRVVFDASKPDGTPRKLLDVTRLHQLGWYHEISLEAGLAST 308 Query: 345 WKWTTEN 351 ++W EN Sbjct: 309 YQWFLEN 315 >2Q1W-A nrPDB Length = 333 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 73/298 (24%), Positives = 128/298 (42%), Gaps = 55/298 (18%) Query: 9 STSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKH-HIPFYE 67 S K V +TG G IGSH L+E G V DN + R E L H ++ F E Sbjct: 19 SHMKKVFITGICGQIGSHIAELLLERGDKVVGIDNFAT------GRREHLKDHPNLTFVE 72 Query: 68 VDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHN---NILGTVVLLELMQQ 124 + D + ++ + + D+V+H A S + P +Y++ N +G +++ ++ Sbjct: 73 GSIADHALVNQLIGDLQPDAVVHTAA------SYKDPDDWYNDTLTNCVGGSNVVQAAKK 126 Query: 125 YNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKS 184 NV +FV+ +A YG P P+ + P P N + YAI N+ Y + Sbjct: 127 NNVGRFVYFQTALCYGVK---PIQQPVRLDHPRNPAN----SSYAISKSANEDY-LEYSG 178 Query: 185 WKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTP 244 F R N +G P + G P+ + +++ G+ K ++ +R Sbjct: 179 LDFVTFRLANVVG--PRNVSGPLPI--------FFQRLSEGK--KCFV----TKAR---- 218 Query: 245 IRDYIHVVDLAKGHIAALQYLEAYNENEGLCR-EWNLGSGKGSTVFEVYHAFCKASGI 301 RD++ V DLA+ + A+ +G+ ++ SG + E+Y A +A + Sbjct: 219 -RDFVFVKDLARATVRAV---------DGVGHGAYHFSSGTDVAIKELYDAVVEAMAL 266 >3M2P-A nrPDB Length = 311 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 72/293 (24%), Positives = 124/293 (42%), Gaps = 59/293 (20%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCDR 73 + VTGG G++G + V + +G ++ L+ S + I YE + D Sbjct: 5 IAVTGGTGFLGQYVVESIKNDGNTPII---LTRS----------IGNKAINDYEYRVSDY 51 Query: 74 KGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFVFS 133 + + + +D+V+H A + +Q + +H+N + T L + + N+S V++ Sbjct: 52 TLEDLINQLNDVDAVVHLAATRG----SQGKISEFHDNEILTQNLYDACYENNISNIVYA 107 Query: 134 SSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDK----KSWKFAI 189 S+ + Y D T P +E PL P YG +K A E+I N +Y+ K K+ +FA Sbjct: 108 STISAYSDETSLP---WNEKELPL-PDLMYGVSKLACEHIGN-IYSRKKGLCIKNLRFAH 162 Query: 190 LRYFNPIGAHPSGLIGEDPLGIPNNLL--PYMAQVAVGRREKLYIFGDDYDSRDGTPIRD 247 L FN NN + + Q G + L+ + R+ Sbjct: 163 LYGFNE----------------KNNYMINRFFRQAFHGEQLTLH--------ANSVAKRE 198 Query: 248 YIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASG 300 +++ D AK I AL+ E + +N+GSG T +EV + A G Sbjct: 199 FLYAKDAAKSVIYALK-------QEKVSGTFNIGSGDALTNYEVANTINNAFG 244 >3SXP-A nrPDB Length = 362 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 76/293 (25%), Positives = 132/293 (45%), Gaps = 52/293 (17%) Query: 5 LQSESTSKIVLVTGGAGYIGSHTVVELIEN--GYDCVVADNLSNSTYDSVARLEVLT--K 60 + E ++ +L+TGGAG++GS+ EN VV D ++T S R L K Sbjct: 4 IDDELENQTILITGGAGFVGSNLAFHFQENHPKAKVVVLDKFRSNTLFSNNRPSSLGHFK 63 Query: 61 HHIPF----YEVDL---CDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRY-YHNNI 112 + I F D+ D + LEK+ D + H A AV ++T + N Sbjct: 64 NLIGFKGEVIAADINNPLDLRRLEKL----HFDYLFHQA---AVSDTTMLNQELVMKTNY 116 Query: 113 LGTVVLLELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIEN 172 + LLE+ + +K +++SSA VYG+ T+ PN++ E P N YG +K ++ Sbjct: 117 QAFLNLLEIARS-KKAKVIYASSAGVYGN-TKAPNVVGKNE----SPENVYGFSKLCMDE 170 Query: 173 ILNDLYNSDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVG----RRE 228 + N + + LRYFN G P E + + Q+A+G + Sbjct: 171 FVLSHSNDNVQVG----LRYFNVYG--PREFYKEKTASM-------VLQLALGAMAFKEV 217 Query: 229 KLYIFGDDYDSRDGTPIRDYIHVVDLAKGHIAALQYLEA--YNENEGLCREWN 279 KL+ FG+ +RD++++ D+ + ++ A++ ++ YN R +N Sbjct: 218 KLFEFGEQ--------LRDFVYIEDVIQANVKAMKAQKSGVYNVGYSQARSYN 262 >5UZH-A nrPDB Length = 345 Score = 52.0 bits (123), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 70/259 (27%), Positives = 116/259 (44%), Gaps = 36/259 (13%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVL------TKHHIP 64 SK+ L+TG G GS+ L+E GY +V + S+ + R+E L TK Sbjct: 1 SKVALITGITGQDGSYLAEFLLEKGY--MVYGIIRRSSSFNTGRVEHLYKDIHITKAKFK 58 Query: 65 FYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQ 124 DL D L + + K D + + A V S ++P + + +GT+ LLE ++ Sbjct: 59 LLYGDLTDTGNLISIIAKIKPDEIYNLAAQSHVKVSFEMPEYTANVDGIGTLRLLEAIRA 118 Query: 125 YNV---SKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTK-YAIENILN--DLY 178 + +KF +S++ +YG +P E P P +PY K Y+ ++N + Y Sbjct: 119 CGLEKKTKFYQASTSELYG----LVQEVPQKETTPFYPRSPYACAKLYSYWIVVNYREAY 174 Query: 179 NSDKKSWKFA---ILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGD 235 N FA IL FN H S I P + + +A++ +G ++ LY+ G+ Sbjct: 175 NM------FALNGIL--FN----HES--IRRGPTFVTRKITMAVARIKLGLQDCLYL-GN 219 Query: 236 DYDSRDGTPIRDYIHVVDL 254 RD +DY+ + L Sbjct: 220 LDAERDWGHAKDYVEAMWL 238 >2Z95-A nrPDB Length = 345 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 78/349 (22%), Positives = 144/349 (41%), Gaps = 58/349 (16%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 + K L+TG G G++ L+E GY+ AD S + S E+ ++ + +D Sbjct: 2 SGKRALITGIRGQDGAYLAKLLLEKGYEVYGADRRSGE-FASWRLKELGIENDVKIIHMD 60 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNV-S 128 L + + + ++ + D V + A VG S + P+ + +G + +LE ++ + Sbjct: 61 LLEFSNIIRTIEKVQPDEVYNLAAQSFVGVSFEQPILTAEVDAIGVLRILEALRTVKPDT 120 Query: 129 KFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTK---YAIENILNDLYNSDKKSW 185 KF +S++ ++G IP E+ P P +PY K + I + YN S Sbjct: 121 KFYQASTSEMFGKVQE----IPQTEKTPFYPRSPYAVAKLFGHWITVNYREAYNMFACS- 175 Query: 186 KFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPI 245 IL FN H S L G + + + +A++ G ++KL + G+ RD Sbjct: 176 --GIL--FN----HESPLRGIE--FVTRKITYSLARIKYGLQDKL-VLGNLNAKRDWGYA 224 Query: 246 RDYIHVVDL------------AKGHIAAL-QYLEAYNENEGLCREWNLGSG--------- 283 +Y+ + L A G + +++E + G EW +G G Sbjct: 225 PEYVEAMWLMMQQPEPDDYVIATGETHTVREFVEKAAKIAGFDIEW-VGEGINEKGIDRN 283 Query: 284 KGSTVFEVYHAFCKASGIDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQ 332 G + EV F + + +D+ L P++A ++L W+ Sbjct: 284 TGKVIVEVSEEFFRPAEVDI--------------LVGNPEKAMKKLGWK 318 >1DB3-A nrPDB Length = 372 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 84/359 (23%), Positives = 139/359 (38%), Gaps = 39/359 (10%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDC----VVADNLSNSTYDSVARLEVLTKHHIPFY 66 SK+ L+TG G GS+ L+E GY+ A + + D + + + Sbjct: 1 SKVALITGVTGQDGSYLAEFLLEKGYEVHGIKRRASSFNTERVDHIYQDPHTCNPKFHLH 60 Query: 67 EVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN 126 DL D L ++ +E + D V + + V S + P + +GT+ LLE ++ Sbjct: 61 YGDLSDTSNLTRILREVQPDEVYNLGAMSHVAVSFESPEYTADVDAMGTLRLLEAIRFLG 120 Query: 127 VSK---FVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKK 183 + K F +S++ +YG IP E P P +PY K I + S Sbjct: 121 LEKKTRFYQASTSELYG----LVQEIPQKETTPFYPRSPYAVAKLYAYWITVNYRESYGM 176 Query: 184 SWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGT 243 IL FN H S GE + + +A +A G LY+ G+ RD Sbjct: 177 YACNGIL--FN----HESPRRGET--FVTRKITRAIANIAQGLESCLYL-GNMDSLRDWG 227 Query: 244 PIRDYIHV------------VDLAKG-HIAALQYLEAYNENEGLCREWNLGSG---KGST 287 +DY+ + +A G + Q++E G+ + G+G KG Sbjct: 228 HAKDYVKMQWMMLQQEQPEDFVIATGVQYSVRQFVEMAAAQLGIKLRFE-GTGVEEKGIV 286 Query: 288 VFEVYHAFCKASGIDLPYKVTGR--RAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDL 344 V H D+ V R R +V L P +A +L W+ E+ + + ++ Sbjct: 287 VSVTGHDAPGVKPGDVIIAVDPRYFRPAEVETLLGDPTKAHEKLGWKPEITLREMVSEM 345 >2X86-A nrPDB Length = 357 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 79/325 (24%), Positives = 136/325 (41%), Gaps = 55/325 (16%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGY-DCVVADNLSNST-YDSVARLEV---LTKHHIPFY 66 ++++VTGGAG+IGS+ V L + G D +V DNL + T + ++ L + + K Sbjct: 47 RMIIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDGTKFVNLVDLNIADYMDKEDFLIQ 106 Query: 67 EVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN 126 + + +E +F E S + G + + Q Y +L + E+ Sbjct: 107 IMAGEEFGDVEAIFHEGACSSTTEWDGKYMMDNNYQ-----YSKELLHYCLEREI----- 156 Query: 127 VSKFVFSSSATVYGDATRFPNMIPIPE-ECPLGPTNPYGHTKYAIENILNDLYNSDKKSW 185 F+++SSA YG T + I E E PL N +G++K+ + + + + + Sbjct: 157 --PFLYASSAATYGGRT--SDFIESREYEKPL---NVFGYSKFLFDEYVRQIL--PEANS 207 Query: 186 KFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPI 245 + RYFN G + N Q+ G KL+ +++ Sbjct: 208 QIVGFRYFNVYGPREGHKGSMASVAFHLN-----TQLNNGESPKLFEGSENFK------- 255 Query: 246 RDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEV------YHAFCKAS 299 RD+++V D+A L +LE G+ +NLG+G+ + V YH + Sbjct: 256 RDFVYVGDVAD---VNLWFLE-----NGVSGIFNLGTGRAESFQAVADATLAYHKKGQIE 307 Query: 300 GIDLPYKVTGR----RAGDVLNLTA 320 I P K+ GR D+ NL A Sbjct: 308 YIPFPDKLKGRYQAFTQADLTNLRA 332 >1EQ2-A nrPDB Length = 310 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 80/324 (24%), Positives = 135/324 (41%), Gaps = 55/324 (16%) Query: 13 IVLVTGGAGYIGSHTVVELIENGY-DCVVADNLSNST-YDSVARLEV---LTKHHIPFYE 67 +++VTGGAG+IGS+ V L + G D +V DNL + T + ++ L + + K Sbjct: 1 MIIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDGTKFVNLVDLNIADYMDKEDFLIQI 60 Query: 68 VDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNV 127 + + +E +F E S + G + + Q Y +L + E+ Sbjct: 61 MAGEEFGDVEAIFHEGACSSTTEWDGKYMMDNNYQ-----YSKELLHYCLEREI------ 109 Query: 128 SKFVFSSSATVYGDATRFPNMIPIPE-ECPLGPTNPYGHTKYAIENILNDLYNSDKKSWK 186 F+++SSA YG R + I E E PL N YG++K+ + + + + + + Sbjct: 110 -PFLYASSAATYG--GRTSDFIESREYEKPL---NVYGYSKFLFDEYVRQIL--PEANSQ 161 Query: 187 FAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIR 246 RYFN G + N Q+ G KL+ +++ R Sbjct: 162 IVGFRYFNVYGPREGHKGSMASVAFHLN-----TQLNNGESPKLFEGSENFK-------R 209 Query: 247 DYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEV------YHAFCKASG 300 D+++V D+A L +LE G+ +NLG+G+ + V YH + Sbjct: 210 DFVYVGDVAD---VNLWFLE-----NGVSGIFNLGTGRAESFQAVADATLAYHKKGQIEY 261 Query: 301 IDLPYKVTGR----RAGDVLNLTA 320 I P K+ GR D+ NL A Sbjct: 262 IPFPDKLKGRYQAFTQADLTNLRA 285 >6GPK-A nrPDB Length = 373 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 50/185 (27%), Positives = 81/185 (43%), Gaps = 17/185 (9%) Query: 2 TAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKH 61 T L +S + L+TG G GS+ L+E GY+ V + S+ + R+E L K+ Sbjct: 15 TENLYFQSMRNVALITGITGQDGSYLAEFLLEKGYE--VHGIVRRSSSFNTGRIEHLYKN 72 Query: 62 -------HIPFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILG 114 ++ + DL D L K+ E K + + V S + + +G Sbjct: 73 PQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVG 132 Query: 115 TVVLLELMQQ---YNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTK-YAI 170 T+ LL+ ++ N KF +S++ +YG IP E P P +PYG K YA Sbjct: 133 TLRLLDAVKTCGLINSVKFYQASTSQLYGKVQE----IPQKETTPFYPRSPYGAAKLYAY 188 Query: 171 ENILN 175 ++N Sbjct: 189 WIVVN 193 >1RPN-A nrPDB Length = 335 Score = 45.4 bits (106), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 42/161 (26%), Positives = 75/161 (46%), Gaps = 6/161 (3%) Query: 9 STSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARL-EVLTKHHIPFYE 67 S ++ LVTG G G++ L+E GY V ++ + D+ RL E+ + I + + Sbjct: 12 SMTRSALVTGITGQDGAYLAKLLLEKGYR--VHGLVARRSSDTRWRLRELGIEGDIQYED 69 Query: 68 VDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN- 126 D+ D +++ + + V + A VG S P+ + LG LLE ++Q++ Sbjct: 70 GDMADACSVQRAVIKAQPQEVYNLAAQSFVGASWNQPVTTGVVDGLGVTHLLEAIRQFSP 129 Query: 127 VSKFVFSSSATVYG--DATRFPNMIPIPEECPLGPTNPYGH 165 ++F +S++ ++G A R P P G YGH Sbjct: 130 ETRFYQASTSEMFGLIQAERQDENTPFYPRSPYGVAKLYGH 170 >4R1T-A nrPDB Length = 337 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 42/149 (28%), Positives = 62/149 (41%), Gaps = 13/149 (8%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVL--TKHHIPFYE 67 + ++V VTG G+I S V L+E GY V + N L L K + + Sbjct: 9 SGQVVCVTGAGGFIASWLVKILLEKGY--TVRGTVRNPDDPKNGHLRELEGAKERLTLCK 66 Query: 68 VDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNV 127 DL D + L + D V H A T P + ++GT ++ + NV Sbjct: 67 ADLLDYQSLREAIN--GCDGVFHTA-----SPVTDDPEQMVEPAVIGTKNVINAAAEANV 119 Query: 128 SKFVFSSS-ATVYGDATRFPNMIPIPEEC 155 + VF+SS VY D R P + + E C Sbjct: 120 RRVVFTSSIGAVYMDPNRDPETV-VDETC 147 >4BZF-A nrPDB Length = 324 Score = 43.1 bits (100), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 49/194 (25%), Positives = 82/194 (42%), Gaps = 29/194 (14%) Query: 394 SIVDLKVNGQSVVLGYENEEGYLNPDSAYIGATIGRYANRISKGKFSLCNKDYQLTVNNG 453 S+VD N Q ++ E E + + + Y G I NRIS G FS + Y +N Sbjct: 36 SLVDKTTNVQ-LLREPETAESFHDTPTLY-GIPILFPPNRISDGTFSFRGRTYHFDINEK 93 Query: 454 VNANHSSIGSFHRKRFLGPIIQNPSKDVFTAEYMLIDNEKD--------TEFPGDLLVTI 505 NH +H K + Q T E ++++ E D +FP +V + Sbjct: 94 DKHNHLHGFLYHEKWNVVTTKQ-------TDEGVIVETEIDLSELPHVQKQFPHHAVVRM 146 Query: 506 QYTV--NVAQKSLEMVYKGKLTAGEATPINLTNHSYFNLNKPYGDTIEGTEIMVRSKKSV 563 YT+ N K ++ KGK EA P + H+ F E + + + + Sbjct: 147 TYTIKENTLFKHATVMNKGK----EAFPWGIGYHTTFIF------PAESSLFSLTADQQW 196 Query: 564 DVDKNMIPTGNIVD 577 ++D+ ++PTG ++D Sbjct: 197 ELDERLLPTGKLMD 210 >1RKX-A nrPDB Length = 357 Score = 42.4 bits (98), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 77/352 (21%), Positives = 138/352 (39%), Gaps = 45/352 (12%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSV---ARLEVLTKHHIPFYEV 68 K V VTG G+ G + L G V +L+ T S+ AR+ + I Sbjct: 10 KRVFVTGHTGFKGGWLSLWLQTMG-ATVKGYSLTAPTVPSLFETARVADGMQSEIG---- 64 Query: 69 DLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVS 128 D+ D+ L + +E++ + V H A V S P+ Y N++GTV LLE ++ Sbjct: 65 DIRDQNKLLESIREFQPEIVFHMAAQPLVRLSYSEPVETYSTNVMGTVYLLEAIRHVGGV 124 Query: 129 KFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFA 188 K V + ++ D + + E +G +PY ++K E + + NS Sbjct: 125 KAVVNITSDKCYDNKEW--IWGYRENEAMGGYDPYSNSKGCAELVTSSYRNS-------- 174 Query: 189 ILRYFNPI--GAHPSG--------LIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYD 238 +FNP G H + +IG + + ++P + + A + + + I Sbjct: 175 ---FFNPANYGQHGTAVATVRAGNVIGGGDWAL-DRIVPDILR-AFEQSQPVII------ 223 Query: 239 SRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLG--SGKGSTVFEVYHAFC 296 R+ IR + HV++ G++ Q L Y + WN G + V + Sbjct: 224 -RNPHAIRPWQHVLEPLSGYLLLAQKL--YTDGAEYAEGWNFGPNDADATPVKNIVEQMV 280 Query: 297 KASGIDLPYKVTGR-RAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKW 347 K G +++ G + L +AK +L W + + + + W Sbjct: 281 KYWGEGASWQLDGNAHPHEAHYLKLDCSKAKMQLGWHPRWNLNTTLEYIVGW 332 >4G5H-A nrPDB Length = 363 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 31/124 (25%), Positives = 55/124 (44%), Gaps = 4/124 (3%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLC 71 KI+L+TGG G G+ + +++ + + D + + + FY D+ Sbjct: 26 KILLITGGTGSFGNAVMKRFLDSNIKEIRIFSRDEKKQDDIRK--KYNNSKLKFYIGDVR 83 Query: 72 DRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFV 131 D + +E ++ +D V H A LK V P+ NI+GT +L+ NV K + Sbjct: 84 DSQSVETAMRD--VDYVFHAAALKQVPSCEFFPVEAVKTNIIGTENVLQSAIHQNVKKVI 141 Query: 132 FSSS 135 S+ Sbjct: 142 CLST 145 >1N7G-A nrPDB Length = 381 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 75/341 (21%), Positives = 129/341 (37%), Gaps = 34/341 (9%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCV-VADNLSNSTYDSVARLEV----LTKHHIPFY 66 KI L+TG G GS+ L+ GY+ + SN + + + + K + + Sbjct: 29 KIALITGITGQDGSYLTEFLLGKGYEVHGLIRRSSNFNTQRINHIYIDPHNVNKALMKLH 88 Query: 67 EVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN 126 DL D L + K D V + A V S +IP G + LLE ++ + Sbjct: 89 YADLTDASSLRRWIDVIKPDEVYNLAAQSHVAVSFEIPDYTADVVATGALRLLEAVRSHT 148 Query: 127 VS-----KFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSD 181 + K+ + S+ ++G P E P P +PY +K A Y + Sbjct: 149 IDSGRTVKYYQAGSSEMFGSTPP-----PQSETTPFHPRSPYAASKCAAH-----WYTVN 198 Query: 182 KKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRD 241 + + + + H S GE+ + + + ++ VG + KL++ G+ SRD Sbjct: 199 YRE-AYGLFACNGILFNHESPRRGEN--FVTRKITRALGRIKVGLQTKLFL-GNLQASRD 254 Query: 242 GTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGI 301 DY+ + L Y+ A E + ++ G ++ Y I Sbjct: 255 WGFAGDYVEAMWLMLQQEKPDDYVVATEEGHTVEEFLDVSFGYLGLNWKDY------VEI 308 Query: 302 DLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCK 342 D Y R +V NL +AK L W+ ++ E K Sbjct: 309 DQRY----FRPAEVDNLQGDASKAKEVLGWKPQVGFEKLVK 345 >3SLK-A nrPDB Length = 795 Score = 40.4 bits (93), Expect = 0.003, Method: Compositional matrix adjust. Identities = 41/139 (29%), Positives = 63/139 (45%), Gaps = 13/139 (9%) Query: 14 VLVTGGAGYIGSHTVVEL-IENGYDCVVADNLSNSTYDSVARLEV-LTKH--HIPFYEVD 69 VLVTGG G +G+ L IE G +V + A L LT + + D Sbjct: 533 VLVTGGTGALGAEVARHLVIERGVRNLVLVSRRGPAASGAAELVAQLTAYGAEVSLQACD 592 Query: 70 LCDRKGLEKVFK----EYKIDSVIHFAGLKAVGESTQIPL----RYYHNNILGTVVLLEL 121 + DR+ L KV E+ + +V+H AG+ G S + + + + G LLEL Sbjct: 593 VADRETLAKVLASIPDEHPLTAVVHAAGVLDDGVSESLTVERLDQVLRPKVDGARNLLEL 652 Query: 122 MQQYNVSKFVFSSSATVYG 140 + +V+ +FSS + V G Sbjct: 653 IDP-DVALVLFSSVSGVLG 670 >2GN9-A nrPDB Length = 344 Score = 39.7 bits (91), Expect = 0.005, Method: Compositional matrix adjust. Identities = 44/198 (22%), Positives = 83/198 (41%), Gaps = 24/198 (12%) Query: 6 QSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPF 65 Q+ ++ +L+TGG G G V +++ D A + + D + + E+ + + P Sbjct: 16 QNMLDNQTILITGGTGSFGKCFVRKVL----DTTNAKKIIVYSRDELKQSEMAMEFNDPR 71 Query: 66 YEVDLCDRKGLEKV-FKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQ 124 + D + LE++ + +D IH A LK V + PL NI+G ++ + Sbjct: 72 MRFFIGDVRDLERLNYALEGVDICIHAAALKHVPIAEYNPLECIKTNIMGASNVINACLK 131 Query: 125 YNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKS 184 +S+ +I + + P N YG TK + + N S Sbjct: 132 NAISQ------------------VIALSTDKAANPINLYGATKLCSDKLFVSANNFKGSS 173 Query: 185 W-KFAILRYFNPIGAHPS 201 +F+++RY N +G+ S Sbjct: 174 QTQFSVVRYGNVVGSRGS 191 >2NNL-D nrPDB Length = 337 Score = 38.5 bits (88), Expect = 0.011, Method: Compositional matrix adjust. Identities = 26/75 (34%), Positives = 37/75 (49%), Gaps = 3/75 (4%) Query: 9 STSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKH--HIPFY 66 S S+ V VTG +G+IGS V+ L+E GY V A + V L L K H+ + Sbjct: 3 SQSETVCVTGASGFIGSWLVMRLLERGYT-VRATVRDPTNVKKVKHLLDLPKAETHLTLW 61 Query: 67 EVDLCDRKGLEKVFK 81 + DL D ++ K Sbjct: 62 KADLADEGSFDEAIK 76 >2C54-A nrPDB Length = 379 Score = 37.7 bits (86), Expect = 0.018, Method: Compositional matrix adjust. Identities = 40/175 (22%), Positives = 74/175 (42%), Gaps = 20/175 (11%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCDR 73 + +TG G+I SH L G+ + +D N E +T+ E L D Sbjct: 32 ISITGAGGFIASHIARRLKHEGHYVIASDWKKN---------EHMTEDMF-CDEFHLVDL 81 Query: 74 KGLEKVFKEYK-IDSVIHFAG-LKAVG--ESTQIPLRYYHNNILGTVVLLELMQQYNVSK 129 + +E K + +D V + A + +G +S + Y NN + + ++E + + + Sbjct: 82 RVMENCLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMY--NNTMISFNMIEAARINGIKR 139 Query: 130 FVFSSSATVYGDATRFPNM---IPIPEECPLGPTNPYGHTKYAIENILNDLYNSD 181 F ++SSA +Y + + + + P P + YG + A E + YN D Sbjct: 140 FFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLERLATEELCKH-YNKD 193 >4WKG-A nrPDB Length = 660 Score = 37.4 bits (85), Expect = 0.021, Method: Compositional matrix adjust. Identities = 48/198 (24%), Positives = 86/198 (43%), Gaps = 34/198 (17%) Query: 14 VLVTGGAGYIGSHTVVELI-ENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCD 72 VL+ G G+IG+H L+ E+ Y+ D S D+++R L H F E D+ Sbjct: 318 VLILGVNGFIGNHLTERLLREDHYEVYGLDIGS----DAISRF--LNHPHFHFVEGDI-- 369 Query: 73 RKGLEKVFKEY---KIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSK 129 + + EY K D V+ + E T+ PLR + + + ++ +Y + Sbjct: 370 --SIHSEWIEYHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYCVKYR-KR 426 Query: 130 FVFSSSATVYGDAT------RFPNMIPIPEECPLGPTNP----YGHTKYAIENILNDLYN 179 +F S++ VYG + N+I +GP N Y +K ++ ++ Sbjct: 427 IIFPSTSEVYGMCSDKYFDEDHSNLI-------VGPVNKPRWIYSVSKQLLDRVI--WAY 477 Query: 180 SDKKSWKFAILRYFNPIG 197 +K+ +F + R FN +G Sbjct: 478 GEKEGLQFTLFRPFNWMG 495 >4J2O-A nrPDB Length = 363 Score = 37.0 bits (84), Expect = 0.028, Method: Compositional matrix adjust. Identities = 39/167 (23%), Positives = 66/167 (39%), Gaps = 30/167 (17%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHH---IPFYEV 68 K++L+TGG G G+ + +E + + D + + K+H + FY Sbjct: 24 KVLLITGGTGSFGNAVLKRFLETDIKEIRIFSRDEKKQDDMRK-----KYHSAKLKFYIG 78 Query: 69 DLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVS 128 D+ D + + +D + H A LK V P+ N+LGT +LE Q +V Sbjct: 79 DVRDYNSILNATR--GVDYIYHAAALKQVPSCEFHPMEAVKTNVLGTENVLEAAIQNHVK 136 Query: 129 KFV-FSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENIL 174 + V S+ VY P N G +K +E ++ Sbjct: 137 RVVCLSTDKAVY-------------------PINAMGISKAMMEKVM 164 >5IZ4-A nrPDB Length = 271 Score = 36.2 bits (82), Expect = 0.051, Method: Compositional matrix adjust. Identities = 23/97 (23%), Positives = 50/97 (51%), Gaps = 11/97 (11%) Query: 6 QSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTK---HH 62 ++S++ + ++TG A IG+ T + + G+ + N +ST D+ + +E L + Sbjct: 9 MTQSSTPVCVITGSASGIGAATALRFAQAGWSVAIG-NFDDSTRDAASTVEALCRDAGAQ 67 Query: 63 IPFYEVDL-----CDRKGLEKVFKEY-KIDSVIHFAG 93 ++ D+ C R ++ V + +ID++I+ AG Sbjct: 68 TLIFDADVGKDADC-RHAVDMVASRWQRIDALINCAG 103 >5ILO-A nrPDB Length = 271 Score = 35.8 bits (81), Expect = 0.072, Method: Compositional matrix adjust. Identities = 23/85 (27%), Positives = 42/85 (49%), Gaps = 5/85 (5%) Query: 15 LVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCDRK 74 +VTGGAG IG +L+ G V +L ++ + V + ++D+ ++K Sbjct: 19 VVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEFVKLRAAHPTQSVMIIKMDVANKK 78 Query: 75 GLEKVFKEYK-----IDSVIHFAGL 94 G+E ++E ID V++ AG+ Sbjct: 79 GVEATYEEIAKTFGNIDIVVNVAGI 103 >2P4H-X nrPDB Length = 322 Score = 35.4 bits (80), Expect = 0.077, Method: Compositional matrix adjust. Identities = 34/130 (26%), Positives = 54/130 (41%), Gaps = 12/130 (9%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVL--TKHHIPFYEVDLC 71 V VTGG G++GS + L+ENGY V+ L L + F+ DL Sbjct: 4 VCVTGGTGFLGSWIIKSLLENGYSVNTTIRADPERKRDVSFLTNLPGASEKLHFFNADLS 63 Query: 72 D----RKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNV 127 + +E + S I F AV E +I + + LG +L + V Sbjct: 64 NPDSFAAAIEGCVGIFHTASPIDF----AVSEPEEIVTKRTVDGALG--ILKACVNSKTV 117 Query: 128 SKFVFSSSAT 137 +F+++SS + Sbjct: 118 KRFIYTSSGS 127 >5B6K-A nrPDB Length = 366 Score = 35.4 bits (80), Expect = 0.090, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 84/206 (40%), Gaps = 31/206 (15%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEV--DLC 71 V V+G G+I H V +L++ Y V+ S D + V+ K YE+ D+ Sbjct: 24 VFVSGATGFIAQHVVRQLLDQNYK-VIGSVRSAEKGDHLKN--VIFKGGDFNYEIVKDIS 80 Query: 72 DRKGLEKVFKEY--KIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQY---N 126 D + VF+++ I V+H A +T I + GT +LE +++Y Sbjct: 81 DPTAFDHVFEKHGKDIKVVLHTASPFHFN-TTDIEKDLLIPAVNGTKGILESIKKYAAQT 139 Query: 127 VSKFVFSSSATVYGDATRFPNMI-------PIPEE---------CPLGPTNPYGHTKYAI 170 V + V +SS + T +M I EE C P Y +K Sbjct: 140 VERVVVTSS---FAANTSTVDMFYAKDSSKTITEESWNQDTWESCQSDPIRGYCGSKKFA 196 Query: 171 ENILNDLYNSDKKSWKFAILRYFNPI 196 E D YN++K S KF L NP+ Sbjct: 197 EKAAWDFYNANKDSVKFK-LSIINPV 221 >3OS7-A nrPDB Length = 341 Score = 35.0 bits (79), Expect = 0.10, Method: Compositional matrix adjust. Identities = 52/218 (23%), Positives = 88/218 (40%), Gaps = 29/218 (13%) Query: 372 DARFVTIGAGTRFQATFANLGASIVDLKVNGQSVVLGYENE-----EGYLNPDSAYIGAT 426 + + + AG ++G ++V+LK + V + + E + N Y G Sbjct: 17 EHKCIRFAAGGYEALIIPDVGGNVVELKDTNKGVTILRTPKKDLKFEDFKNRPQVY-GLP 75 Query: 427 IGRYANRISKGKFSLCNKDYQLTVNNGVNANH------SSIGSFHRKRFLGPIIQNPSKD 480 + NRI G F L +K Y+ +N N N+ +S + H+K+ I Sbjct: 76 VLFPPNRIDDGTFKLGDKTYKFPINEAKNNNYIHGFIKNSKWTVHKKK-----IDQDKAL 130 Query: 481 VFTAEYMLIDNEKDTEFPGDLLVTIQYTVNVAQKSLEMVYKGKLTAGEATPINLTNHSYF 540 V +NE F + + Y ++ K L+ + E P+++ HS F Sbjct: 131 VEVVFDFTKENEAYKYFSHEFQFKLSY--ELSSKGLKQTTSVVNLSSEEMPLSVGYHSAF 188 Query: 541 NLNKPYGDTIEGTEIM-VRSKKSVD----VDKNMIPTG 573 N+ P+ IEG+E R K S+D D +PTG Sbjct: 189 NV--PF---IEGSEDSNCRVKISIDKFWKQDSRNLPTG 221 >4BKP-A nrPDB Length = 336 Score = 34.3 bits (77), Expect = 0.17, Method: Compositional matrix adjust. Identities = 61/264 (23%), Positives = 105/264 (39%), Gaps = 34/264 (12%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 S +LVTGG+G +G + +++ +G D + S+ D+ DL Sbjct: 22 SMRILVTGGSGLVGK-AIQKVVADGAGLPGEDWVFVSSKDA-----------------DL 63 Query: 71 CDRKGLEKVFKEYKIDSVIHFAGL-KAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSK 129 D +F++ + VIH A + + + + L ++ N+ +L + K Sbjct: 64 TDTAQTRALFEKVQPTHVIHLAAMVGGLFRNIKYNLDFWRKNVHMNDNVLHSAFEVGARK 123 Query: 130 FVFSSSATVYGDATRFP-NMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFA 188 V S ++ D T +P + I P Y + K I+ + N Y + F Sbjct: 124 VVSCLSTCIFPDKTTYPIDETMIHNGPPHNSNFGYSYAKRMID-VQNRAY-FQQYGCTFT 181 Query: 189 ILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDY 248 + N G H + I ED +P L + +A L ++G G P R + Sbjct: 182 AVIPTNVFGPHDNFNI-EDGHVLPG--LIHKVHLAKSSGSALTVWG------TGNPRRQF 232 Query: 249 IHVVDLAKGHIAALQYLEAYNENE 272 I+ +DLA+ I L+ YNE E Sbjct: 233 IYSLDLAQLFIWVLR---EYNEVE 253 >1ZZE-A nrPDB Length = 342 Score = 33.9 bits (76), Expect = 0.22, Method: Compositional matrix adjust. Identities = 13/24 (54%), Positives = 19/24 (79%) Query: 13 IVLVTGGAGYIGSHTVVELIENGY 36 +VLVTG G++ SH V +L+E+GY Sbjct: 13 LVLVTGANGFVASHVVEQLLEHGY 36 >4R1U-A nrPDB Length = 349 Score = 33.9 bits (76), Expect = 0.23, Method: Compositional matrix adjust. Identities = 37/133 (27%), Positives = 56/133 (42%), Gaps = 12/133 (9%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVL--TKHHIPFYEVD 69 + V VTG G+I S V L+E GY V + N L+ L + + ++VD Sbjct: 28 QTVCVTGAGGFIASWLVKLLLERGY--TVRGTVRNPEDPKNGHLKELEGARERLTLHKVD 85 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSK 129 L D + ++ V + V H A T P + GT ++ + V + Sbjct: 86 LLDLQSIQSVV--HGCHGVFHTA-----SPVTDNPDEMLEPAVNGTKNVIIASAEAKVRR 138 Query: 130 FVFSSS-ATVYGD 141 VF+SS TVY D Sbjct: 139 VVFTSSIGTVYMD 151 >3A28-C nrPDB Length = 258 Score = 33.9 bits (76), Expect = 0.26, Method: Compositional matrix adjust. Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 3/74 (4%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVAD--NLSNSTYDSVARLEVLTKHHIPFYEV 68 SK+ +VTGGA IG +L +G+D VAD +++ +E + + F + Sbjct: 2 SKVAMVTGGAQGIGRGISEKLAADGFDIAVADLPQQEEQAAETIKLIEAADQKAV-FVGL 60 Query: 69 DLCDRKGLEKVFKE 82 D+ D+ + E Sbjct: 61 DVTDKANFDSAIDE 74 >5ITV-A nrPDB Length = 255 Score = 33.1 bits (74), Expect = 0.44, Method: Compositional matrix adjust. Identities = 26/86 (30%), Positives = 42/86 (48%), Gaps = 9/86 (10%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 T K VL+TGGA IG V + + VVAD + + +++ R E + H F + D Sbjct: 6 TDKTVLITGGASGIGYAAVQAFLGQQANVVVAD-IDEAQGEAMVRKENNDRLH--FVQTD 62 Query: 70 LCDRKGLEKVFKEYKIDSVIH-FAGL 94 + D ++ ++S +H F GL Sbjct: 63 ITDEAAC-----QHAVESAVHTFGGL 83 >3PXX-A nrPDB Length = 287 Score = 32.7 bits (73), Expect = 0.53, Method: Compositional matrix adjust. Identities = 35/115 (30%), Positives = 53/115 (46%), Gaps = 18/115 (15%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVAD----------NLSNSTYDSVARLEV-LTK 60 K+VLVTGGA G V+L E G D ++ D L+ S A LEV T Sbjct: 11 KVVLVTGGARGQGRSHAVKLAEEGADIILFDICHDIETNEYPLATSRDLEEAGLEVEKTG 70 Query: 61 HHIPFYEVDLCDRKGLEK----VFKEY-KIDSVIHFAGLKAVGESTQIPLRYYHN 110 EVD+ DR + + E+ K+D V+ AG+ +G +P++ + + Sbjct: 71 RKAYTAEVDVRDRAAVSRELANAVAEFGKLDVVVANAGICPLG--AHLPVQAFAD 123 >3WYE-A nrPDB Length = 256 Score = 32.3 bits (72), Expect = 0.68, Method: Compositional matrix adjust. Identities = 19/62 (30%), Positives = 32/62 (51%), Gaps = 1/62 (1%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLC 71 K+ LVTG IG + L+++G+ +AD +++T +VA H +VD+ Sbjct: 3 KVALVTGAGQGIGKAIALRLVKDGFAVAIAD-YNDATAKAVASEINQAGGHAVAVKVDVS 61 Query: 72 DR 73 DR Sbjct: 62 DR 63 >1GEG-A nrPDB Length = 256 Score = 32.0 bits (71), Expect = 0.91, Method: Compositional matrix adjust. Identities = 19/62 (30%), Positives = 32/62 (51%), Gaps = 1/62 (1%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLC 71 K+ LVTG IG + L+++G+ +AD +++T +VA H +VD+ Sbjct: 3 KVALVTGAGQGIGKAIALRLVKDGFAVAIAD-YNDATAKAVASEINQAGGHAVAVKVDVS 61 Query: 72 DR 73 DR Sbjct: 62 DR 63 >5U9C-A nrPDB Length = 292 Score = 31.6 bits (70), Expect = 1.2, Method: Compositional matrix adjust. Identities = 21/76 (27%), Positives = 40/76 (52%), Gaps = 9/76 (11%) Query: 7 SESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVAD----NLSNS----TYDSVARLEVL 58 S + + +L+TGG G +G++ L + Y+ +V + NLS +Y + + +V+ Sbjct: 1 SNAMKRKILITGGTGMLGAYVTSALKDTDYNVIVTERNTLNLSVPEAIFSYITAEKPDVI 60 Query: 59 TKHHIPFYEVDLCDRK 74 H +VDLC+R+ Sbjct: 61 L-HFAAETDVDLCERE 75 >4K6F-A nrPDB Length = 255 Score = 31.2 bits (69), Expect = 1.6, Method: Compositional matrix adjust. Identities = 27/104 (25%), Positives = 49/104 (47%), Gaps = 15/104 (14%) Query: 1 MTAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTK 60 M T +I +VTGG G +G + L + G+ VV + +N+ D LT+ Sbjct: 1 MAHHHHHHMTKRIAVVTGGMGGLGEAVSIRLNDAGHRVVVTYSPNNTGAD-----RWLTE 55 Query: 61 HHIP-----FYEVDLCD----RKGLEKVFKEY-KIDSVIHFAGL 94 H Y VD+ D ++ +EK+ ++ +D +++ AG+ Sbjct: 56 MHAAGREFHAYPVDVADHDSCQQCIEKIVRDVGPVDILVNNAGI 99 >4AVY-A nrPDB Length = 242 Score = 30.8 bits (68), Expect = 1.9, Method: Compositional matrix adjust. Identities = 22/87 (25%), Positives = 43/87 (49%), Gaps = 16/87 (18%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVV----ADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 VLVTGG+ IG+ ++ E G + V AD + + + R E+D Sbjct: 14 VLVTGGSSGIGAAIAMQFAELGAEVVALGLDADGVHAPRHPRIRR-----------EELD 62 Query: 70 LCDRKGLEKVFKEY-KIDSVIHFAGLK 95 + D + L+++F+ ++D +++ AG+ Sbjct: 63 ITDSQRLQRLFEALPRLDVLVNNAGIS 89 >4KMS-A nrPDB Length = 249 Score = 30.8 bits (68), Expect = 2.1, Method: Compositional matrix adjust. Identities = 28/90 (31%), Positives = 49/90 (54%), Gaps = 11/90 (12%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 S+I +VTGG IG T +EL G VVA+ SN YD+ +E K+ I ++ Sbjct: 10 SEIAIVTGGTRGIGKATALELKNKGL-TVVANFFSN--YDAAKEME--EKYGIKTKCWNV 64 Query: 71 CD----RKGLEKVFKEYK--IDSVIHFAGL 94 D R+ ++++ +E+K + +++ AG+ Sbjct: 65 ADFEECRQAVKEIEEEFKKPVSILVNNAGI 94 >3VR3-A nrPDB Length = 600 Score = 30.4 bits (67), Expect = 2.7, Method: Compositional matrix adjust. Identities = 11/22 (50%), Positives = 16/22 (72%) Query: 662 FAIEPGRYIDAINQENWKDCVT 683 ++ E GRY+D I Q++W D VT Sbjct: 444 YSTEVGRYMDQILQQDWSDMVT 465 >1KO7-A nrPDB Length = 314 Score = 30.0 bits (66), Expect = 3.1, Method: Compositional matrix adjust. Identities = 14/31 (45%), Positives = 20/31 (64%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNL 44 VL+TG +G S T +ELI+ G+ V DN+ Sbjct: 147 VLITGDSGIGKSETALELIKRGHRLVADDNV 177 >2AX4-A nrPDB Length = 198 Score = 30.0 bits (66), Expect = 3.6, Method: Compositional matrix adjust. Identities = 18/76 (23%), Positives = 39/76 (51%), Gaps = 12/76 (15%) Query: 63 IPFYEV------DLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTV 116 +PF+E+ ++C+ + ++ ++K + + F G+ + E + P R N L TV Sbjct: 121 LPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSDYEKPETPERVLKTN-LSTV 179 Query: 117 V-----LLELMQQYNV 127 ++EL+Q+ N+ Sbjct: 180 SDCVHQVVELLQEQNI 195 >5XCC-A nrPDB Length = 476 Score = 29.6 bits (65), Expect = 4.4, Method: Compositional matrix adjust. Identities = 24/101 (23%), Positives = 46/101 (45%), Gaps = 2/101 (1%) Query: 288 VFEVYHAFCKASGIDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKW 347 V+E A+ + +GI L Y+ T + + N + +L + V+DS K L Sbjct: 262 VYENIKAYAE-TGITLNYQATLNKDAVISNKENLGNTNNIQLDYTNNPHVKDSYKKLTDK 320 Query: 348 TTENPFGYQLRGVEARFSAEDMRYDARFVTIGAGTRFQATF 388 T FG+ + V++ +++ ++ A F AG + A + Sbjct: 321 VTTYTFGFGITKVDSELNSKLLQ-GAEFSVKDAGGKIVAKY 360 >6GCS-E nrPDB Length = 375 Score = 29.6 bits (65), Expect = 4.8, Method: Compositional matrix adjust. Identities = 27/132 (20%), Positives = 60/132 (45%), Gaps = 13/132 (9%) Query: 6 QSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVA--DNLSNSTYDSVARLEVLTKHHI 63 +S T V G G++GS+ +L ++G VV + ++ L V+ Sbjct: 48 RSSRTGYTATVFGANGFLGSYLTAKLAKHGTTVVVPYREEMAKRHLKVTGDLGVVN---- 103 Query: 64 PFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQ 123 F E+DL + + +++ + D V++ G E YY ++ G + E ++ Sbjct: 104 -FLEMDLRNLESIDEAVRHS--DIVVNLIG----REYETKNFNYYDVHVEGARRIAEAVK 156 Query: 124 QYNVSKFVFSSS 135 ++N+++++ S+ Sbjct: 157 KHNIARYIHVSA 168 >1YXM-A nrPDB Length = 303 Score = 29.3 bits (64), Expect = 6.5, Method: Compositional matrix adjust. Identities = 14/31 (45%), Positives = 20/31 (64%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVAD 42 ++ +VTGGA IG V EL+E G + V+A Sbjct: 19 QVAIVTGGATGIGKAIVKELLELGSNVVIAS 49 >3S8M-A nrPDB Length = 422 Score = 28.9 bits (63), Expect = 8.1, Method: Compositional matrix adjust. Identities = 20/55 (36%), Positives = 28/55 (50%), Gaps = 8/55 (14%) Query: 331 WQTELQVEDSCKDLW-KWTTENPF------GYQLRGVEA-RFSAEDMRYDARFVT 377 W+ V+D+CK LW + TTEN F GY+ ++ F D+ YDA T Sbjct: 358 WELRDDVQDACKALWPQVTTENLFELTDYAGYKHEFLKLFGFGRTDVDYDADVAT 412 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1Z45-A nrPDB 993 0.0 4LIS-A nrPDB 398 e-111 1YGA-A nrPDB 397 e-111 1UDA-A nrPDB 382 e-106 1I3M-A nrPDB 378 e-105 3ENK-A nrPDB 374 e-104 1SNZ-A nrPDB 344 1e-94 2C20-A nrPDB 338 6e-93 1LUR-A nrPDB 331 1e-90 1GY8-A nrPDB 315 4e-86 4WOK-A nrPDB 315 6e-86 6BI4-A nrPDB 292 3e-79 4RNL-A nrPDB 287 9e-78 1L7J-A nrPDB 284 7e-77 1BXK-A nrPDB 275 3e-74 2HUN-A nrPDB 274 9e-74 1KEU-A nrPDB 267 1e-71 6BWL-A nrPDB 263 2e-70 1R66-A nrPDB 263 3e-70 1DB3-A nrPDB 255 4e-68 1WVG-A nrPDB 255 4e-68 1ORR-A nrPDB 245 6e-65 1N7G-A nrPDB 243 1e-64 5UZH-A nrPDB 240 2e-63 6GPK-A nrPDB 240 2e-63 3RUE-A nrPDB 239 3e-63 2Z95-A nrPDB 238 6e-63 3IMH-A nrPDB 238 8e-63 1OC2-A nrPDB 237 1e-62 1RKX-A nrPDB 236 3e-62 2Q1T-A nrPDB 233 1e-61 2PK3-A nrPDB 232 3e-61 2PZM-A nrPDB 217 1e-56 1RPN-A nrPDB 215 4e-56 2Q1W-A nrPDB 200 2e-51 1GFS-A nrPDB 198 8e-51 2X86-A nrPDB 192 5e-49 1EQ2-A nrPDB 192 5e-49 3SXP-A nrPDB 185 9e-47 4EJ0-A nrPDB 179 5e-45 3M2P-A nrPDB 178 6e-45 4BZF-A nrPDB 171 8e-43 4G5H-A nrPDB 126 2e-29 4R1T-A nrPDB 125 8e-29 Sequences not found previously or not previously below threshold: 2C54-A nrPDB 137 1e-32 4WKG-A nrPDB 116 3e-26 4J2O-A nrPDB 115 9e-26 4BKP-A nrPDB 112 7e-25 2GN9-A nrPDB 107 2e-23 4R1U-A nrPDB 103 3e-22 3WMX-A nrPDB 101 1e-21 6AQY-A nrPDB 98 1e-20 2NNL-D nrPDB 94 2e-19 5B6K-A nrPDB 92 7e-19 4KTT-E nrPDB 91 1e-18 3OS7-A nrPDB 89 5e-18 2P4H-X nrPDB 87 2e-17 4QUK-A nrPDB 85 1e-16 3RFT-A nrPDB 81 2e-15 3HFS-A nrPDB 81 2e-15 5U9C-A nrPDB 80 3e-15 1VL0-A nrPDB 79 4e-15 4PVC-A nrPDB 78 2e-14 3SC6-A nrPDB 77 2e-14 4WPG-A nrPDB 74 1e-13 2GGS-A nrPDB 73 6e-13 3PVZ-A nrPDB 66 5e-11 1KC3-A nrPDB 66 7e-11 1ZZE-A nrPDB 65 1e-10 5YWN-A nrPDB 62 1e-09 3U5T-A nrPDB 61 2e-09 6GCS-E nrPDB 61 3e-09 3SLK-A nrPDB 60 3e-09 4QQR-A nrPDB 59 6e-09 3NRE-A nrPDB 54 2e-07 2GDZ-A nrPDB 53 4e-07 6NRP-A nrPDB 53 5e-07 3V8B-A nrPDB 51 1e-06 3V2G-A nrPDB 51 1e-06 3UN1-A nrPDB 50 3e-06 4IIV-A nrPDB 50 4e-06 3KZV-A nrPDB 49 5e-06 5ILO-A nrPDB 49 5e-06 1YXM-A nrPDB 49 5e-06 3A28-C nrPDB 49 8e-06 4AVY-A nrPDB 49 1e-05 5ITV-A nrPDB 48 1e-05 3WYE-A nrPDB 48 1e-05 4MOW-A nrPDB 48 1e-05 5U9P-A nrPDB 48 2e-05 1K2W-A nrPDB 48 2e-05 1QYC-A nrPDB 48 2e-05 4B4O-A nrPDB 47 2e-05 5VT6-A nrPDB 47 2e-05 4K6F-A nrPDB 47 3e-05 2V6G-A nrPDB 47 3e-05 6G2J-P nrPDB 47 4e-05 2QYS-A nrPDB 46 4e-05 6CI9-A nrPDB 46 7e-05 3WOH-A nrPDB 46 8e-05 4IIN-A nrPDB 45 1e-04 2PNF-A nrPDB 45 1e-04 3VZS-A nrPDB 45 1e-04 2NM0-A nrPDB 45 1e-04 3U9L-A nrPDB 44 1e-04 1GEG-A nrPDB 44 1e-04 3WTC-A nrPDB 44 2e-04 3Q1N-A nrPDB 44 2e-04 5GUP-L nrPDB 44 3e-04 1N5D-A nrPDB 44 3e-04 3PXX-A nrPDB 44 3e-04 3RWB-A nrPDB 43 4e-04 3DCD-A nrPDB 43 4e-04 4E6P-A nrPDB 43 4e-04 5OVL-A nrPDB 42 6e-04 1UZM-A nrPDB 42 6e-04 4CQL-A nrPDB 42 6e-04 1BDB-A nrPDB 42 7e-04 1QYD-A nrPDB 42 7e-04 3D3W-A nrPDB 42 8e-04 2HSD-A nrPDB 42 0.001 3DWF-A nrPDB 42 0.001 6CGE-A nrPDB 42 0.001 1A27-A nrPDB 42 0.001 5OVJ-A nrPDB 42 0.001 5YSS-A nrPDB 42 0.001 3EZL-A nrPDB 42 0.001 5IZ4-A nrPDB 41 0.001 3OSU-A nrPDB 41 0.001 4NBT-A nrPDB 41 0.002 2EW8-A nrPDB 41 0.002 5PGZ-A nrPDB 41 0.002 2Q2Q-A nrPDB 41 0.002 4JRO-A nrPDB 41 0.002 3ZV3-A nrPDB 40 0.003 3EMK-A nrPDB 40 0.003 4IS3-A nrPDB 40 0.003 4BO1-A nrPDB 40 0.004 1OOE-A nrPDB 39 0.006 5LCX-A nrPDB 39 0.008 4KMS-A nrPDB 39 0.008 5F5N-A nrPDB 39 0.008 4RGB-A nrPDB 39 0.008 2Q4B-A nrPDB 39 0.009 1HE4-A nrPDB 39 0.010 2O23-A nrPDB 39 0.010 2HRB-A nrPDB 38 0.013 3RKU-A nrPDB 37 0.020 2B4Q-A nrPDB 37 0.020 3GRP-A nrPDB 37 0.021 2GAS-A nrPDB 37 0.022 3RSH-A nrPDB 37 0.022 3F9I-A nrPDB 37 0.023 4CR6-A nrPDB 37 0.028 1H5Q-A nrPDB 37 0.032 2C07-A nrPDB 37 0.032 2VO1-A nrPDB 37 0.036 1AHH-A nrPDB 37 0.036 4FC7-A nrPDB 37 0.037 2X9N-A nrPDB 37 0.037 3OEC-A nrPDB 36 0.057 2BC1-A nrPDB 36 0.057 3ORF-A nrPDB 36 0.065 3UVE-A nrPDB 36 0.072 1AE1-A nrPDB 36 0.075 5B1Y-A nrPDB 36 0.077 1Q7C-A nrPDB 36 0.079 4DBZ-A nrPDB 36 0.083 1E3W-A nrPDB 36 0.084 2UVD-A nrPDB 36 0.088 3OML-A nrPDB 35 0.091 3O4R-A nrPDB 35 0.12 2ZCU-A nrPDB 35 0.12 3H0K-A nrPDB 35 0.13 2QK4-A nrPDB 35 0.13 5CDY-A nrPDB 35 0.13 3T7C-A nrPDB 35 0.13 3VKI-A nrPDB 35 0.13 3PPI-A nrPDB 35 0.14 5O3Z-A nrPDB 34 0.16 1HXH-A nrPDB 34 0.19 3KYB-A nrPDB 34 0.19 3MJ4-A nrPDB 34 0.26 6BAL-A nrPDB 34 0.32 6ACQ-A nrPDB 34 0.33 4E21-A nrPDB 34 0.33 3LYL-A nrPDB 33 0.34 5ER0-A nrPDB 33 0.34 3UF0-A nrPDB 33 0.36 3BHI-A nrPDB 33 0.37 2DKN-A nrPDB 33 0.42 4NBV-A nrPDB 33 0.48 4OV4-A nrPDB 33 0.50 2ZAT-A nrPDB 33 0.52 1CYD-A nrPDB 33 0.52 3PQF-A nrPDB 33 0.54 4DA9-A nrPDB 33 0.56 5A9T-A nrPDB 32 0.57 4ECM-A nrPDB 32 0.58 4RZI-B nrPDB 32 0.59 3AUT-A nrPDB 32 0.60 4TRR-A nrPDB 32 0.61 4HP8-A nrPDB 32 0.62 3OIC-A nrPDB 32 0.63 1GEE-A nrPDB 32 0.66 4DMM-A nrPDB 32 0.68 2CDH-G nrPDB 32 0.70 4CQM-B nrPDB 32 0.77 1V9L-A nrPDB 32 0.83 3E9N-A nrPDB 32 0.86 1LSS-A nrPDB 32 0.87 4DRY-A nrPDB 32 0.99 1NFF-A nrPDB 32 1.1 4J8L-A nrPDB 32 1.2 6AQE-A nrPDB 32 1.3 4UUM-A nrPDB 32 1.3 5EJ2-A nrPDB 31 1.4 5X6R-A nrPDB 31 1.4 3F6T-A nrPDB 31 1.5 1P33-A nrPDB 31 1.5 2PH3-A nrPDB 31 1.5 2LDB-A nrPDB 31 1.6 5T5Q-A nrPDB 31 1.6 3RP7-A nrPDB 31 1.7 5OJG-A nrPDB 31 1.9 5OKP-A nrPDB 31 1.9 2UYY-A nrPDB 31 2.0 3NR8-B nrPDB 31 2.0 3IB3-A nrPDB 31 2.1 6CHD-A nrPDB 31 2.1 2BK5-A nrPDB 31 2.4 2ATV-A nrPDB 31 2.8 4G65-A nrPDB 30 2.9 1O5W-A nrPDB 30 3.1 3TTE-A nrPDB 30 3.1 4YU5-A nrPDB 30 3.2 1O89-A nrPDB 30 3.3 5DBI-A nrPDB 30 3.4 2YV2-A nrPDB 30 4.5 4RZH-A nrPDB 30 4.5 5JS6-A nrPDB 29 5.4 4RHL-A nrPDB 29 6.1 >1Z45-A nrPDB Length = 699 Score = 993 bits (2567), Expect = 0.0, Method: Composition-based stats. Identities = 698/699 (99%), Positives = 699/699 (100%) Query: 1 MTAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTK 60 MTAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTK Sbjct: 1 MTAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTK 60 Query: 61 HHIPFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLE 120 HHIPFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLE Sbjct: 61 HHIPFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLE 120 Query: 121 LMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNS 180 LMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNS Sbjct: 121 LMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNS 180 Query: 181 DKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSR 240 DKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSR Sbjct: 181 DKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSR 240 Query: 241 DGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASG 300 DGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASG Sbjct: 241 DGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASG 300 Query: 301 IDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQLRGV 360 IDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQLRGV Sbjct: 301 IDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQLRGV 360 Query: 361 EARFSAEDMRYDARFVTIGAGTRFQATFANLGASIVDLKVNGQSVVLGYENEEGYLNPDS 420 EARFSAEDMRYDARFVTIGAGTRFQATFANLGASIVDLKVNGQSVVLGYENEEGYLNPDS Sbjct: 361 EARFSAEDMRYDARFVTIGAGTRFQATFANLGASIVDLKVNGQSVVLGYENEEGYLNPDS 420 Query: 421 AYIGATIGRYANRISKGKFSLCNKDYQLTVNNGVNANHSSIGSFHRKRFLGPIIQNPSKD 480 AYIGATIGRYANRISKGKFSLCNKDYQLTVNNGVNANHSSIGSFHRKRFLGPIIQNPSKD Sbjct: 421 AYIGATIGRYANRISKGKFSLCNKDYQLTVNNGVNANHSSIGSFHRKRFLGPIIQNPSKD 480 Query: 481 VFTAEYMLIDNEKDTEFPGDLLVTIQYTVNVAQKSLEMVYKGKLTAGEATPINLTNHSYF 540 VFTAEYMLIDNEKDTEFPGDLLVTIQYTVNVAQKSLE+VYKGKLTAGEATPINLTNHSYF Sbjct: 481 VFTAEYMLIDNEKDTEFPGDLLVTIQYTVNVAQKSLEIVYKGKLTAGEATPINLTNHSYF 540 Query: 541 NLNKPYGDTIEGTEIMVRSKKSVDVDKNMIPTGNIVDREIATFNSTKPTVLGPKNPQFDC 600 NLNKPYGDTIEGTEIMVRSKKSVDVDKNMIPTGNIVDREIATFNSTKPTVLGPKNPQFDC Sbjct: 541 NLNKPYGDTIEGTEIMVRSKKSVDVDKNMIPTGNIVDREIATFNSTKPTVLGPKNPQFDC 600 Query: 601 CFVVDENAKPSQINTLNNELTLIVKAFHPDSNITLEVLSTEPTYQFYTGDFLSAGYEARQ 660 CFVVDENAKPSQINTLNNELTLIVKAFHPDSNITLEVLSTEPTYQFYTGDFLSAGYEARQ Sbjct: 601 CFVVDENAKPSQINTLNNELTLIVKAFHPDSNITLEVLSTEPTYQFYTGDFLSAGYEARQ 660 Query: 661 GFAIEPGRYIDAINQENWKDCVTLKNGETYGSKIVYRFS 699 GFAIEPGRYIDAINQENWKDCVTLKNGETYGSKIVYRFS Sbjct: 661 GFAIEPGRYIDAINQENWKDCVTLKNGETYGSKIVYRFS 699 >4LIS-A nrPDB Length = 371 Score = 398 bits (1023), Expect = e-111, Method: Composition-based stats. Identities = 207/359 (57%), Positives = 259/359 (72%), Gaps = 16/359 (4%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 S VLVTGG GYIGS T + L+E GY VVADNL NS+ +++ R+E+++ F ++D+ Sbjct: 3 SGSVLVTGGTGYIGSFTTLALLEAGYKVVVADNLYNSSAEALNRIELISGKKAEFAQLDV 62 Query: 71 CDRKGLEKVFKEY-KIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSK 129 D +KVF+ + IDSVIHFA LKAVGES + PL YYH N+ GT+ LL M ++NV+ Sbjct: 63 TDEAAFDKVFEAHPDIDSVIHFAALKAVGESGEKPLDYYHVNVYGTICLLRSMVRHNVTN 122 Query: 130 FVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKS----- 184 VFSSSATVYGDATRFP+MIPIPE CPLGPTNPYG+TK+AIE + D+ N+ + + Sbjct: 123 IVFSSSATVYGDATRFPDMIPIPEHCPLGPTNPYGNTKFAIELAITDVINAQRNNAKKAG 182 Query: 185 -------WKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDY 237 W A+LRYFNP GAHPSG++GEDP G+P NLLP +AQVA G+REKL +FGDDY Sbjct: 183 NETEAAKWNGALLRYFNPAGAHPSGIMGEDPQGVPYNLLPLLAQVATGKREKLLVFGDDY 242 Query: 238 DSRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCK 297 S DGT IRDYIH++DLA GH+ AL YL A N R WNLG+G+GSTV+E+ AF K Sbjct: 243 ASHDGTAIRDYIHILDLADGHLKALNYLRA---NNPGVRAWNLGTGRGSTVYEMIRAFSK 299 Query: 298 ASGIDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQ 356 A G DLPY+V RRAGDVLNLT+ P RA EL W+ + +E +C+DLW WT NP GY+ Sbjct: 300 AVGRDLPYEVAPRRAGDVLNLTSNPTRANTELGWKAQRTLEQACEDLWLWTKNNPQGYR 358 >1YGA-A nrPDB Length = 342 Score = 397 bits (1020), Expect = e-111, Method: Composition-based stats. Identities = 171/329 (51%), Positives = 232/329 (70%), Gaps = 7/329 (2%) Query: 376 VTIGAGTRFQATFANLGASIVDLKVNGQSVVLGYENEEGYLNPDSAYIGATIGRYANRIS 435 +TIG +FQAT A LGA++VDLKVNGQSVV GY N + YL D +GAT+GRYANRI+ Sbjct: 13 ITIGDEKKFQATIAPLGATLVDLKVNGQSVVQGYSNVQDYL-TDGNMMGATVGRYANRIA 71 Query: 436 KGKFSLCNKDYQLTVNNGVNANHSSIGSFHRKRFLGPIIQNPSKDVFTAEYMLIDNEKD- 494 KG FSL + ++LTVNN N NHSSI S + K++ ++NPSK V+ E+ L+D+ Sbjct: 72 KGVFSLDDGPHKLTVNNCGNTNHSSISSLNLKQYKASPVENPSKGVYVVEFKLLDDHTQP 131 Query: 495 --TEFPGDLLVTIQYTVNVAQKSLEMVYKGKLTAGEATPINLTNHSYFNLNKPYGD-TIE 551 EFPGDL VT++YT+NVA+ +L+M Y+ +L G+ATPIN+TNHSYFNLNK + +I Sbjct: 132 NPNEFPGDLEVTVKYTLNVAEMTLDMEYQAQLVRGDATPINMTNHSYFNLNKVKSEKSIR 191 Query: 552 GTEIMVRSKKSVDVDKN-MIPTGNIVDREIATFNSTKPTVLGPKNPQFDCCFVVDENAKP 610 GTE+ V S KS++V + ++PTG I++R IATF+STKPTVL P FDC F++D N Sbjct: 192 GTEVKVCSNKSLEVTEGALLPTGKIIERNIATFDSTKPTVLHEDTPVFDCTFIIDANKDL 251 Query: 611 SQINTLN-NELTLIVKAFHPDSNITLEVLSTEPTYQFYTGDFLSAGYEARQGFAIEPGRY 669 ++++ N+L + KA+HP+S+I EV +TEPT YTGD L + R GFA++ GRY Sbjct: 252 KTTDSVSVNKLVPVFKAYHPESHIKFEVSTTEPTVHLYTGDNLCGKFVPRSGFAVQQGRY 311 Query: 670 IDAINQENWKDCVTLKNGETYGSKIVYRF 698 +DAIN++ W+ CV LK GE Y SK Y+F Sbjct: 312 VDAINRDEWRGCVLLKRGEVYTSKTQYKF 340 >1UDA-A nrPDB Length = 338 Score = 382 bits (981), Expect = e-106, Method: Composition-based stats. Identities = 169/345 (48%), Positives = 227/345 (65%), Gaps = 10/345 (2%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLC 71 VLVTGG+GYIGSHT V+L++NG+D ++ DNL NS + +E L H F E D+ Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 Query: 72 DRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFV 131 + + ++ ++ ID+VIHFAGLKAVGES Q PL YY NN+ GT+ L+ M+ NV F+ Sbjct: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120 Query: 132 FSSSATVYGDATRFPNMIPIPEECPLG-PTNPYGHTKYAIENILNDLYNSDKKSWKFAIL 190 FSSSATVYGD + IP E P G P +PYG +K +E IL DL + + W A+L Sbjct: 121 FSSSATVYGDNPK----IPYVESFPTGTPQSPYGKSKLMVEQILTDLQKA-QPDWSIALL 175 Query: 191 RYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYIH 250 RYFNP+GAHPSG +GEDP GIPNNL+PY+AQVAVGRR+ L IFG+DY + DGT +RDYIH Sbjct: 176 RYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIH 235 Query: 251 VVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYKVTGR 310 V+DLA GH+ A++ L N+ +NLG+G G++V +V +AF KA G + Y R Sbjct: 236 VMDLADGHVVAMEKL----ANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPR 291 Query: 311 RAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGY 355 R GD+ A +A REL W+ +++ +D W W + +P GY Sbjct: 292 REGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGY 336 >1I3M-A nrPDB Length = 348 Score = 378 bits (971), Expect = e-105, Method: Composition-based stats. Identities = 186/353 (52%), Positives = 242/353 (68%), Gaps = 16/353 (4%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSN------STYDSVARLEVLTKHHI 63 ++ VLVTGGAGYIGSHTV+EL+E GY VV DN N S +S+ R++ LT + Sbjct: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 Query: 64 PFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQ 123 F E+D+ D+ L+++FK+Y +VIHFAGLKA+GES Q PL YY N+ GT+ LLE+M+ Sbjct: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAMGESVQKPLDYYRVNLTGTIQLLEIMK 120 Query: 124 QYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGP-TNPYGHTKYAIENILNDLYNSDK 182 + V VFSSSATVYG+ P +P+ E P G TNPYG +K+ IE ++ DL +D Sbjct: 121 AHGVKNLVFSSSATVYGN----PQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQAD- 175 Query: 183 KSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDG 242 K+W +LRYFNP GAH SG IGEDP GIPNNL+PY++QVA+GRRE L +FG+DYD+ DG Sbjct: 176 KTWNVVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDG 235 Query: 243 TPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGID 302 T +RDYIHVVDLAKGHIAAL+ L+ CR +NLG+G G +V ++ A KASG Sbjct: 236 TGVRDYIHVVDLAKGHIAALRKLKEQCG----CRIYNLGTGTGYSVLQMVQAMEKASGKK 291 Query: 303 LPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGY 355 +PYKV RR GDV A P A+ EL W L ++ C+DLW+W +NP G+ Sbjct: 292 IPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGF 344 >3ENK-A nrPDB Length = 341 Score = 374 bits (960), Expect = e-104, Method: Composition-based stats. Identities = 184/349 (52%), Positives = 232/349 (66%), Gaps = 9/349 (2%) Query: 7 SESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFY 66 S ST +LVTGGAGYIGSHT VEL+ +GYD V+ADNL NS +++AR+E +T F+ Sbjct: 1 SMSTKGTILVTGGAGYIGSHTAVELLAHGYDVVIADNLVNSKREAIARIEKITGKTPAFH 60 Query: 67 EVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN 126 E D+ D + L ++F + I + IHFA LKAVGES P+ YY NN+ + LL +M++ Sbjct: 61 ETDVSDERALARIFDAHPITAAIHFAALKAVGESVAKPIEYYRNNLDSLLSLLRVMRERA 120 Query: 127 VSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWK 186 V + VFSSSATVYG P PI E PL TNPYG TK E IL D+ +D SW+ Sbjct: 121 VKRIVFSSSATVYG----VPERSPIDETFPLSATNPYGQTKLMAEQILRDVEAAD-PSWR 175 Query: 187 FAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIR 246 A LRYFNP+GAH SGLIGEDP GIPNNL+PY+AQVAVG+ EKL +FG DY + DGT +R Sbjct: 176 VATLRYFNPVGAHESGLIGEDPAGIPNNLMPYVAQVAVGKLEKLRVFGSDYPTPDGTGVR 235 Query: 247 DYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYK 306 DYIHVVDLA+GHIAAL LE + + + NLG+G+G +V EV AF KASG +PY+ Sbjct: 236 DYIHVVDLARGHIAALDALERRDASLTV----NLGTGRGYSVLEVVRAFEKASGRAVPYE 291 Query: 307 VTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGY 355 + RR GDV A P A + W+ E +E C D W+W NP G+ Sbjct: 292 LVARRPGDVAECYANPAAAAETIGWKAERDLERMCADHWRWQENNPRGF 340 >1SNZ-A nrPDB Length = 344 Score = 344 bits (881), Expect = 1e-94, Method: Composition-based stats. Identities = 100/319 (31%), Positives = 150/319 (47%), Gaps = 37/319 (11%) Query: 395 IVDLKVNGQSVVLGYENEEGYLNPDSAYIGATIGRYANRISKGKFSLCNKDYQLTVNNGV 454 + D + VVLG+ EGYL Y GA IGR ANRI+KG F + K+Y L +N Sbjct: 47 VKDRQGRASDVVLGFAELEGYLQK-QPYFGAVIGRVANRIAKGTFKVDGKEYHLAINKEP 105 Query: 455 NANHSSIGSFHRKRFLGPIIQNPSKDVFTAEYMLIDNEKDTEFPGDLLVTIQYTVNVAQK 514 N+ H + F + + ++ N ++ I + + +PG+L V + YT++ Sbjct: 106 NSLHGGVRGFDKVLWTPRVLSN------GVQFSRISPDGEEGYPGELKVWVTYTLDGG-- 157 Query: 515 SLEMVYKGKLTAGEATPINLTNHSYFNLNKPYGDTIEGTEIMVRSKKSVDVDKNMIPTGN 574 E++ + A +ATP+NLTNHSYFNL I E+ + + + VD+ +IPTG Sbjct: 158 --ELIVNYRAQASQATPVNLTNHSYFNLAGQASPNINDHEVTIEADTYLPVDETLIPTGE 215 Query: 575 IVDREIATFNSTKPTVLGPKNPQ------FDCCFVVDENAKPSQINTLNNELTLIVKAFH 628 + + F+ KP LG K+ Q FD F + + E + H Sbjct: 216 VAPVQGTAFDLRKPVELG-KHLQDFHLNGFDHNFCLKG----------SKEKHFCARVHH 264 Query: 629 PDSNITLEVLSTEPTYQFYTGDFLSAG--------YEARQGFAIEPGRYIDAINQENWKD 680 S LEV +T+P QFYTG+FL Y GF +E + DA+NQ + Sbjct: 265 AASGRVLEVYTTQPGVQFYTGNFLDGTLKGKNGAVYPKHSGFCLETQNWPDAVNQPRFPP 324 Query: 681 CVTLKNGETYGSKIVYRFS 699 V L+ GE Y ++FS Sbjct: 325 -VLLRPGEEYDHTTWFKFS 342 >2C20-A nrPDB Length = 330 Score = 338 bits (866), Expect = 6e-93, Method: Composition-based stats. Identities = 141/347 (40%), Positives = 201/347 (57%), Gaps = 19/347 (5%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 +L+ GGAGYIGSH V +L++ G VV DNL D++ FY DL Sbjct: 1 MNSILICGGAGYIGSHAVKKLVDEGLSVVVVDNLQTGHEDAIT-------EGAKFYNGDL 53 Query: 71 CDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKF 130 D+ L VF + I++V+HFA VG S + PL+YY+NN+ G + LLE+M ++ V KF Sbjct: 54 RDKAFLRDVFTQENIEAVMHFAADSLVGVSMEKPLQYYNNNVYGALCLLEVMDEFKVDKF 113 Query: 131 VFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAIL 190 +FSS+A YG+ ++ I EE PTN YG TK AIE +L+ + S + ++ I Sbjct: 114 IFSSTAATYGEV----DVDLITEETMTNPTNTYGETKLAIEKMLH--WYSQASNLRYKIF 167 Query: 191 RYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYIH 250 RYFN GA P+G+IGED +L+P + QVA+G+REK+ +FGDDY++ DGT IRDYIH Sbjct: 168 RYFNVAGATPNGIIGEDHRP-ETHLIPLVLQVALGQREKIMMFGDDYNTPDGTCIRDYIH 226 Query: 251 VVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYKVTGR 310 V DL H L+ L +N G +NLG+G G +V E+ A + + ++P +V R Sbjct: 227 VEDLVAAHFLGLKDL----QNGGESDFYNLGNGNGFSVKEIVDAVREVTNHEIPAEVAPR 282 Query: 311 RAGDVLNLTAKPDRAKRELKWQTE-LQVEDSCKDLWKWTTENPFGYQ 356 RAGD L A +AK +L W + V+ + W W + P GY+ Sbjct: 283 RAGDPARLVASSQKAKEKLGWDPRYVNVKTIIEHAWNWHQKQPNGYE 329 >1LUR-A nrPDB Length = 339 Score = 331 bits (847), Expect = 1e-90, Method: Composition-based stats. Identities = 93/342 (27%), Positives = 153/342 (44%), Gaps = 36/342 (10%) Query: 375 FVTIGAGTRFQATFANLGASIVDLKV---NG--QSVVLGYENEEGYLNPDSAYIGATIGR 429 F+ I AT GA++ L NG Q +VLG++ + + D+A IG T+GR Sbjct: 14 FIEIANKQGLTATLLPFGATLAKLTFPDKNGKNQDLVLGFDTIDEF-EKDAASIGKTVGR 72 Query: 430 YANRISKGKFSLCNKDYQLTVNNGVNANHSSIGSFHRKRFLGPIIQNPSKDVFTAEYMLI 489 ANRI K Y +T NNG + H +++ ++++ + + + Sbjct: 73 VANRIKNSTLHFDGKQYTMTPNNGPHYLHGGPNGLGYRKW--EVVRHAPES---VSFSVR 127 Query: 490 DNEKDTEFPGDLLVTIQYTVNVAQKSLEMVYKGKLTAGEATPINLTNHSYFNLNKPYGDT 549 NE+D PGD + + YTVN +++ + T + LTNH+Y+NL+ DT Sbjct: 128 ANEQDDGLPGDAKIDVTYTVNDRN---QLIIEHHATCDTPGLLALTNHAYWNLDG--SDT 182 Query: 550 IEGTEIMVRSKKSVDVDKNMIPTGNI--VDREIATFNSTKPTVLGPKNPQ----FDCCFV 603 + + + + + V+VD PTG I V F S K K+ + D V Sbjct: 183 VAEHFLEMEADEFVEVDDTFCPTGAIRSVTDTGFDFRSGKQLKESGKDAEELLDLDNDLV 242 Query: 604 VDENAKPSQINTLNNELTLIVKAFHPDSNITLEVLSTEPTYQFYTGDFLSAG------YE 657 + + PS +T ++ + S I L + ++ P Y FL Y+ Sbjct: 243 ITKKTPPSTPSTY-------LRFWSEKSGIELSITTSYPVIHLYASKFLDCKGKKGEHYK 295 Query: 658 ARQGFAIEPGRYIDAINQENWKDCVTLKNGETYGSKIVYRFS 699 A + AIEP + A N +++ D V+L+ G+ Y +IVY FS Sbjct: 296 ANKALAIEPQFHSAAPNFDHFPD-VSLRPGDHYCQEIVYTFS 336 >1GY8-A nrPDB Length = 397 Score = 315 bits (807), Expect = 4e-86, Method: Composition-based stats. Identities = 133/384 (34%), Positives = 190/384 (49%), Gaps = 40/384 (10%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIEN-GYDCVVADNLSNS--------TYDSVAR-LEVLT 59 + VLV GGAGYIGSH V L+ + + V+ D+L + T ++VAR L+ Sbjct: 1 SHMRVLVCGGAGYIGSHFVRALLRDTNHSVVIVDSLVGTHGKSDHVETRENVARKLQQSD 60 Query: 60 KHHIP-------FYEVDLCDRKGLEKVFKEYKI-DSVIHFAGLKAVGESTQIPLRYYHNN 111 P D+ + L VF + D+V+H AVGES + PL+YY NN Sbjct: 61 GPKPPWADRYAALEVGDVRNEDFLNGVFTRHGPIDAVVHMCAFLAVGESVRDPLKYYDNN 120 Query: 112 ILGTVVLLELMQQYNVSKFVFSSSATVYGDATRFP---NMIPIPEECPLGPTNPYGHTKY 168 ++G + LL+ M + K +FSSSA ++G+ T N PI P +PYG +K Sbjct: 121 VVGILRLLQAMLLHKCDKIIFSSSAAIFGNPTMGSVSTNAEPIDINAKKSPESPYGESKL 180 Query: 169 AIENILNDLYNSDKKSWKFAILRYFNPIGAHPSGLIGEDPLG----IPNNLLPYMAQVAV 224 E ++ D ++ K LRYFN GAH G IGE G IP L M+ +A Sbjct: 181 IAERMIRDC--AEAYGIKGICLRYFNACGAHEDGDIGEHYQGSTHLIPIILGRVMSDIAP 238 Query: 225 GRR----------EKLYIFGDDYDSRDGTPIRDYIHVVDLAKGHIAALQYLEAYNEN--E 272 +R +++ IFG DY + DGT +RDY+HV DLA HI AL Y+E N Sbjct: 239 DQRLTIHEDASTDKRMPIFGTDYPTPDGTCVRDYVHVCDLASAHILALDYVEKLGPNDKS 298 Query: 273 GLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQ 332 +NLG+ +G +V EV K +G +P + GRR GD L A D+A+ L W+ Sbjct: 299 KYFSVFNLGTSRGYSVREVIEVARKTTGHPIPVRECGRREGDPAYLVAASDKAREVLGWK 358 Query: 333 TEL-QVEDSCKDLWKWTTENPFGY 355 + +E + WK+ +P GY Sbjct: 359 PKYDTLEAIMETSWKFQRTHPNGY 382 >4WOK-A nrPDB Length = 336 Score = 315 bits (806), Expect = 6e-86, Method: Composition-based stats. Identities = 128/350 (36%), Positives = 181/350 (51%), Gaps = 23/350 (6%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 ++ VLV GGAG+IGSHT L GY VV DNLS +V F E D Sbjct: 10 SANNVLVVGGAGFIGSHTAKLLAGQGYAPVVYDNLSTGHQSAVRWG--------DFVEGD 61 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSK 129 + D+ L + ++Y +VIHFA VGES + P +YY NN+ GT LL+ + Sbjct: 62 ILDQARLVETMEKYAPVAVIHFAASAYVGESVEDPAKYYRNNVGGTQSLLDACRLTRTQN 121 Query: 130 FVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAI 189 +FSSS YG P+ +PI E P NPYG TK E++L D + ++ Sbjct: 122 VIFSSSCATYG----VPSRLPIGEGEAQNPINPYGRTKLIAEHMLADY--AVAYGLRYVA 175 Query: 190 LRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYI 249 LRYFN GA G +GE +L+P A GR + L ++GDDY++ DGT IRDYI Sbjct: 176 LRYFNASGADIDGELGEKHDP-ETHLIPRAMMAAAGRLDVLEVYGDDYETPDGTCIRDYI 234 Query: 250 HVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYKVTG 309 HV DLA+ H+ A+++L+ N + NLG+G+G+++ E+ + + +G +P + Sbjct: 235 HVTDLARAHVLAVEHLKEAGGNLAV----NLGTGRGTSIREIVQSIGRLTGRSVPVAMRA 290 Query: 310 RRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQLRG 359 RRAGD L A P A +L + T D T FG ++RG Sbjct: 291 RRAGDPPALYADPALAAEKLGFHTVYS----DLDTIIRTAAPHFGLEVRG 336 >6BI4-A nrPDB Length = 346 Score = 292 bits (747), Expect = 3e-79, Method: Composition-based stats. Identities = 90/358 (25%), Positives = 152/358 (42%), Gaps = 33/358 (9%) Query: 2 TAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYD-SVARLEVLTK 60 T L +S + +LVTGGAG+IGS+ V ++++ Y+ N TY ++ ++ + Sbjct: 15 TENLYFQSNAMNILVTGGAGFIGSNFVHYMLQS-YETYKIINFDALTYSGNLNNVKSIQD 73 Query: 61 H-HIPFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLL 119 H + F + ++ + + LE V KE + +++FA V S + P+ +Y N++GTV LL Sbjct: 74 HPNYYFVKGEIQNGELLEHVIKERDVQVIVNFAAESHVDRSIENPIPFYDTNVIGTVTLL 133 Query: 120 ELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYN 179 EL+++Y K V S+ VYG + EE PL P +PY +K + + I Y Sbjct: 134 ELVKKYPHIKLVQVSTDEVYGSLGKTGRF---TEETPLAPNSPYSSSKASADMIALAYY- 189 Query: 180 SDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDS 239 + R N G P P L+P M A+ +KL ++G Sbjct: 190 -KTYQLPVIVTRCSNNYG----------PYQYPEKLIPLMVTNAL-EGKKLPLYG----- 232 Query: 240 RDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKAS 299 DG +RD++HV D L + +N+G T EV Sbjct: 233 -DGLNVRDWLHVTDHCSAIDVVLH-------KGRVGEVYNIGGNNEKTNVEVVEQIITLL 284 Query: 300 GIDLP-YKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQ 356 G + R G ++ K E W+ + E ++ +W +N ++ Sbjct: 285 GKTKKDIEYVTDRLGHDRRYAINAEKMKNEFDWEPKYTFEQGLQETVQWYEKNEEWWK 342 >4RNL-A nrPDB Length = 343 Score = 287 bits (735), Expect = 9e-78, Method: Composition-based stats. Identities = 82/309 (26%), Positives = 133/309 (43%), Gaps = 32/309 (10%) Query: 400 VNGQSVVLGYENEEGYLNPDSAYIGATIGRYANRISKGKFSLCNKDYQLTVNNGVNANHS 459 + GQ + LG+ + Y +Y GA +GRYANRI+ F L + LT NNG ++ H Sbjct: 56 MRGQ-LALGFADLASYAAHGGSYFGALVGRYANRIAGASFVLDGRTDALTPNNGRHSLHG 114 Query: 460 SIGSFHRKRFLGPIIQNPSKDVFTAEYMLIDNEKDTEFPGDLLVTIQYTVNVAQKSLEMV 519 G F R ++ + + + + + + FPG L V + YT++ +L +V Sbjct: 115 GPGGFSR------VVWDAREVDGGVQLHRVSPDGEEGFPGALDVRVTYTLSAG--ALRIV 166 Query: 520 YKGKLTAGEATPINLTNHSYFNLNKPYGDTIEGTEIMVRSKKSVDVDKNMIPTGNIV-DR 578 A T +NLTNH+Y NL + G E+ + + + VD IP + Sbjct: 167 SCATTDA--PTVVNLTNHTYLNLGGDGSGSAAGHELRLAASRYTPVDGTGIPVPGAPAEV 224 Query: 579 EIATFNSTKPTVLGPKNPQFDCCFVVDENAKPSQINTLNNELTLIVKAFHPDSNITLEVL 638 F+ + +D F +D + + + + + P S L + Sbjct: 225 TGTRFDFRAARAVAG---AYDHNFALDGGVREAPRT--------VAELYDPRSGRALALA 273 Query: 639 STEPTYQFYTGDFLSAG--------YEARQGFAIEPGRYIDAINQENWKDCVTLKNGETY 690 +TEP Q YT D L Y G A+E + D+ N+ ++ V L+ GE+Y Sbjct: 274 TTEPGLQLYTADHLDGTLTGTSGVPYGPAAGLALETQHFPDSPNRPDFPSTV-LRPGESY 332 Query: 691 GSKIVYRFS 699 S+ VY FS Sbjct: 333 RSETVYAFS 341 >1L7J-A nrPDB Length = 347 Score = 284 bits (727), Expect = 7e-77, Method: Composition-based stats. Identities = 85/351 (24%), Positives = 153/351 (43%), Gaps = 41/351 (11%) Query: 368 DMRYDARFVTIGAGTRFQATFANLGASIVDLKVNGQSVVLGYENEEGYLNPDSAYIGATI 427 D + +++ +F NLGA IVD + +G+ ++LG+++ + YL D AY GAT+ Sbjct: 7 DFGLGSDLISLTNKAGVTISFTNLGARIVDWQKDGKHLILGFDSAKEYLEKD-AYPGATV 65 Query: 428 GRYANRISKGKFSLCNKDYQLTVNNGVNANHSSIGSFHRKRFLGPIIQNPSKDVFTAEYM 487 G A RI G + KDY L N G H S H K + + ++ ++ Sbjct: 66 GPTAGRIKDGLVKISGKDYILNQNEGPQTLHGGEESIHTKLWTYEVTDLGAEVQ--VKFS 123 Query: 488 LIDNEKDTEFPGDLLVTIQYTVNVAQKSLEMVYKGKLTAGEATPINLTNHSYFNLNKPYG 547 L+ N+ +PG + +++ ++ + K ++ Y+ + + T N T H YFNLN Sbjct: 124 LVSNDGTNGYPGKIEMSVTHSFDDDNK-WKIHYE--AISDKDTVFNPTGHVYFNLNGDAS 180 Query: 548 DTIEGTEIMVRSKKSVDV-DKNMIPTGNIVDREIA------------TFNSTKPTVLGPK 594 +++E + + + + V + D+ I G+IVD + FNS V K Sbjct: 181 ESVENHGLRLAASRFVPLKDQTEIVRGDIVDIKNTDLDFRQEKQLSNAFNSNMEQVQLVK 240 Query: 595 NPQFDCCFVVDENAKPSQINTLNNELTLIVKAFHPDSNITLEVLSTEPTYQFYTGDFLSA 654 D F++D+ ++ LTL + ++ V + +P+ +T +F Sbjct: 241 G--IDHPFLLDQLG----LDKEQARLTL--------DDTSISVFTDQPSIVIFTANFGDL 286 Query: 655 G---YEARQ----GFAIEPGRYIDAINQENWKDCVTLKNGETYGSKIVYRF 698 G +E +Q G E + Q ++LK GE Y + +Y Sbjct: 287 GTLYHEKKQVHHGGITFECQVSPGS-EQIPELGDISLKAGEKYQATTIYSL 336 >1BXK-A nrPDB Length = 355 Score = 275 bits (704), Expect = 3e-74, Method: Composition-based stats. Identities = 85/367 (23%), Positives = 136/367 (37%), Gaps = 49/367 (13%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 + +L+TGGAG+IGS V +I D VV + + ++ V F +VD+ Sbjct: 1 MRKILITGGAGFIGSALVRYIINETSDAVVVVDKLTYAGNLMSLAPVAQSERFAFEKVDI 60 Query: 71 CDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQY----- 125 CDR L +VF E++ D V+H A V S P + NI+GT LLE + Y Sbjct: 61 CDRAELARVFTEHQPDCVMHLAAESHVDRSIDGPAAFIETNIVGTYTLLEAARAYWNALT 120 Query: 126 ----NVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSD 181 + +F S+ VYGD + E P P++PY +K + ++++ Sbjct: 121 EDKKSAFRFHHISTDEVYGDLHSTDDF--FTETTPYAPSSPYSASKASSDHLVRAW--LR 176 Query: 182 KKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRD 241 I N G P P L+P M A+ + L ++G + Sbjct: 177 TYGLPTLITNCSNNYG----------PYHFPEKLIPLMILNALA-GKSLPVYG------N 219 Query: 242 GTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGI 301 G IRD+++V D A+ L + +N+G +V C+ Sbjct: 220 GQQIRDWLYVEDHARA-------LYCVATTGKVGETYNIGGHNERKNLDVVETICELLEE 272 Query: 302 DLP------------YKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTT 349 P R G L + REL + E + +W Sbjct: 273 LAPNKPHGVAHYRDLITFVADRPGHDLRYAIDASKIARELGCVPQETFESGMRKTVQWYL 332 Query: 350 ENPFGYQ 356 N ++ Sbjct: 333 ANESWWK 339 >2HUN-A nrPDB Length = 336 Score = 274 bits (701), Expect = 9e-74, Method: Composition-based stats. Identities = 86/351 (24%), Positives = 157/351 (44%), Gaps = 37/351 (10%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVL-TKHHIPFYEV 68 S +LVTGG G+IGS+ + ++E D V + + A L+ L F + Sbjct: 2 HSMKLLVTGGMGFIGSNFIRYILEKHPDWEVINIDKLGYGSNPANLKDLEDDPRYTFVKG 61 Query: 69 DLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVS 128 D+ D + ++++ + K+D V+H A V S P + H+N++GT LLE +++ N Sbjct: 62 DVADYELVKELVR--KVDGVVHLAAESHVDRSISSPEIFLHSNVIGTYTLLESIRRENPE 119 Query: 129 -KFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKF 187 +FV S+ VYGD + E L P++PY TK A + ++ + + Sbjct: 120 VRFVHVSTDEVYGDILKG----SFTENDRLMPSSPYSATKAASDMLVLGW--TRTYNLNA 173 Query: 188 AILRYFNPIGAHPSGLIGEDPLGIPNNLLPY-MAQVAVGRREKLYIFGDDYDSRDGTPIR 246 +I R N G P P L+P + + ++G K+ I+G G +R Sbjct: 174 SITRCTNNYG----------PYQFPEKLIPKTIIRASLGL--KIPIYGT------GKNVR 215 Query: 247 DYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLP-Y 305 D+++V D H+ A++ + E+ +N+ +G+ T EV + G Sbjct: 216 DWLYVED----HVRAIELVLLKGESR---EIYNISAGEEKTNLEVVKIILRLMGKGEELI 268 Query: 306 KVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQ 356 ++ R G L + + R+LKW+ + ++ K W +N + ++ Sbjct: 269 ELVEDRPGHDLRYSLDSWKITRDLKWRPKYTFDEGIKKTIDWYLKNEWWWK 319 >1KEU-A nrPDB Length = 361 Score = 267 bits (682), Expect = 1e-71, Method: Composition-based stats. Identities = 85/368 (23%), Positives = 140/368 (38%), Gaps = 53/368 (14%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTY-DSVARLEVLTK-HHIPFYEVD 69 +L+TGGAG+IGS V +I+N D VV N+ TY ++ L +++ + F D Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQDTVV--NIDKLTYAGNLESLSDISESNRYNFEHAD 58 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQY---- 125 +CD + ++F++Y+ D+V+H A V S P + NI+GT LLE+ ++Y Sbjct: 59 ICDSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYALLEVARKYWSAL 118 Query: 126 -----NVSKFVFSSSATVYGDATRFPNMIP------IPEECPLGPTNPYGHTKYAIENIL 174 N +F S+ VYGD + E P++PY +K + ++++ Sbjct: 119 GEDKKNNFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDHLV 178 Query: 175 NDLYNSDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFG 234 + N G P P L+P + A+ + L I+G Sbjct: 179 RAWR--RTYGLPTIVTNCSNNYG----------PYHFPEKLIPLVILNAL-EGKPLPIYG 225 Query: 235 DDYDSRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHA 294 G IRD+++V D A+ L +N+G +V Sbjct: 226 K------GDQIRDWLYVEDHARA-------LHMVVTEGKAGETYNIGGHNEKKNLDVVFT 272 Query: 295 FC--------KASGIDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWK 346 C KA+ R G + REL W+ E + + Sbjct: 273 ICDLLDEIVPKATSYREQITYVADRPGHDRRYAIDAGKISRELGWKPLETFESGIRKTVE 332 Query: 347 WTTENPFG 354 W N Sbjct: 333 WYLANTQW 340 >6BWL-A nrPDB Length = 328 Score = 263 bits (671), Expect = 2e-70, Method: Composition-based stats. Identities = 91/351 (25%), Positives = 150/351 (42%), Gaps = 35/351 (9%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLC 71 +LVTGGAG+IG V L+++ ++ + DNL+NST ++ + D+ Sbjct: 1 MKILVTGGAGFIGRWVVKRLLQDKHEVWILDNLANSTTANITEFAHDLNLKQC-IQGDIK 59 Query: 72 DRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFV 131 D+K + ++F+ D H A V +S + N+ +GT LLE Y+V K V Sbjct: 60 DKKLVAQLFENNSFDLCYHLAASINVQDSIDDARATFENDTIGTFNLLEQCLNYDV-KMV 118 Query: 132 FSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAILR 191 F S+ VY AT N+ I E P+ P +PY +K A EN++ Y + K ++R Sbjct: 119 FMSTCMVYDKAT---NIQGISELDPIKPASPYAGSKIAAENMVLSYYYAYK--LPVVVIR 173 Query: 192 YFNPIGA--HPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYI 249 FN G G G + I N L L I+G DG RD + Sbjct: 174 PFNTYGPFQKTGGEGGVVAIFINNKL----------DNVPLNIYG------DGKQTRDLL 217 Query: 250 HVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYKVTG 309 +V D A +AA +A N G+G+ ++ ++ + + + + Sbjct: 218 YVEDCADFVVAAGYSAKANG------HIINAGTGQDISINKLAELI-SGNKVSIQHVTHI 270 Query: 310 RRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTE---NPFGYQL 357 ++ L ++AK L W+ ++ +ED +W NP +L Sbjct: 271 HPQSEIQKLLCNYEKAKTILNWEPKVSLEDGVIKTEEWIKSLKINPKEKEL 321 >1R66-A nrPDB Length = 337 Score = 263 bits (671), Expect = 3e-70, Method: Composition-based stats. Identities = 79/352 (22%), Positives = 130/352 (36%), Gaps = 40/352 (11%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGY------DCVVADNLSNSTYDSVARLEVLTKHHIPF 65 +LVTGGAG+IGSH V +L+ Y + +V D+L + V + F Sbjct: 1 MRLLVTGGAGFIGSHFVRQLLAGAYPDVPADEVIVLDSL-TYAGNRANLAPVDADPRLRF 59 Query: 66 YEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQY 125 D+ D L + + +D+++HFA V S + N+ GT LL+ Sbjct: 60 VHGDIRDAGLLARELR--GVDAIVHFAAESHVDRSIAGASVFTETNVQGTQTLLQCAVDA 117 Query: 126 NVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSW 185 V + V S+ VYG + E PL P +PY +K + + Sbjct: 118 GVGRVVHVSTDEVYGSI----DSGSWTESSPLEPNSPYAASKAGSDLVARAY--HRTYGL 171 Query: 186 KFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPI 245 I R N G P P L+P + L ++G DG + Sbjct: 172 DVRITRCCNNYG----------PYQHPEKLIPLFVTNLL-DGGTLPLYG------DGANV 214 Query: 246 RDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDL-P 304 R+++H D +G L +++G G T E+ + G D Sbjct: 215 REWVHTDDHCRGIALVL-------AGGRAGEIYHIGGGLELTNRELTGILLDSLGADWSS 267 Query: 305 YKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQ 356 + R G L + + +REL ++ ++ D +W EN ++ Sbjct: 268 VRKVADRKGHDLRYSLDGGKIERELGYRPQVSFADGLARTVRWYRENRGWWE 319 >1DB3-A nrPDB Length = 372 Score = 255 bits (652), Expect = 4e-68, Method: Composition-based stats. Identities = 81/360 (22%), Positives = 136/360 (37%), Gaps = 39/360 (10%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVA----DNLSNSTYDSVARLEVLTKHHIPFY 66 SK+ L+TG G GS+ L+E GY+ + + D + + + Sbjct: 1 SKVALITGVTGQDGSYLAEFLLEKGYEVHGIKRRASSFNTERVDHIYQDPHTCNPKFHLH 60 Query: 67 EVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN 126 DL D L ++ +E + D V + + V S + P + +GT+ LLE ++ Sbjct: 61 YGDLSDTSNLTRILREVQPDEVYNLGAMSHVAVSFESPEYTADVDAMGTLRLLEAIRFLG 120 Query: 127 VSK---FVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKK 183 + K F +S++ +YG IP E P P +PY K I + S Sbjct: 121 LEKKTRFYQASTSELYG----LVQEIPQKETTPFYPRSPYAVAKLYAYWITVNYRESYGM 176 Query: 184 SWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGT 243 IL FN H S GE + + +A +A G LY+ G+ RD Sbjct: 177 YACNGIL--FN----HESPRRGET--FVTRKITRAIANIAQGLESCLYL-GNMDSLRDWG 227 Query: 244 PIRDYIHVVDLAKG-------------HIAALQYLEAYNENEGLCREWNLGSG---KGST 287 +DY+ + + + Q++E G+ + G+G KG Sbjct: 228 HAKDYVKMQWMMLQQEQPEDFVIATGVQYSVRQFVEMAAAQLGIKLRFE-GTGVEEKGIV 286 Query: 288 VFEVYHAFCKASGIDLPYKVTGR--RAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLW 345 V H D+ V R R +V L P +A +L W+ E+ + + ++ Sbjct: 287 VSVTGHDAPGVKPGDVIIAVDPRYFRPAEVETLLGDPTKAHEKLGWKPEITLREMVSEMV 346 >1WVG-A nrPDB Length = 359 Score = 255 bits (652), Expect = 4e-68, Method: Composition-based stats. Identities = 83/352 (23%), Positives = 135/352 (38%), Gaps = 35/352 (9%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 K V VTG G+ GS + L E G V L T S+ + L + + D Sbjct: 8 QGKRVFVTGHTGFKGSWLSLWLTEMG-AIVKGYALDAPTVPSLFEIVRL-NDLMESHIGD 65 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQY-NVS 128 + D + L E+K + V H A V S + P++ Y N++GTV LLE ++Q N+ Sbjct: 66 IRDFEKLRSSIAEFKPEIVFHMAAQPLVRLSYEQPIKTYSTNVMGTVHLLETVKQVGNIK 125 Query: 129 KFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNS-------D 181 V +S Y + + E P+G +PY ++K E + + NS + Sbjct: 126 AVVNITSDKCYDNREW---VWGYRENEPMGGYDPYSNSKGCAELVASAFRNSFFNPANYE 182 Query: 182 KKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRD 241 + A +R N IG G +D L+P + + ++ + R+ Sbjct: 183 QHGVGLASVRAGNVIG---GGDWAKD------RLIPDILRSFENNQQVII--------RN 225 Query: 242 GTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLG--SGKGSTVFEVYHAFCKAS 299 IR + HV++ G+I Q L Y E WN G TV + Sbjct: 226 PYSIRPWQHVLEPLSGYIVVAQRL--YTEGAKFSEGWNFGPRDEDAKTVEFIVDKMVTLW 283 Query: 300 GIDLPYKVTG-RRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTE 350 G D + + G + L +A +L W + ++ + KW Sbjct: 284 GDDASWLLDGENHPHEAHYLKLDCSKANMQLGWHPRWGLTETLSRIVKWHKA 335 >1ORR-A nrPDB Length = 347 Score = 245 bits (624), Expect = 6e-65, Method: Composition-based stats. Identities = 77/354 (21%), Positives = 141/354 (39%), Gaps = 34/354 (9%) Query: 13 IVLVTGGAGYIGSHTVVELIENGYDCVVADNLSN-STYDSVARLEVLTKHHIPFYEVDLC 71 +L+TGG G++GS+ + G D +V DNLS D++ L L F D+ Sbjct: 3 KLLITGGCGFLGSNLASFALSQGIDLIVFDNLSRKGATDNLHWLSSLGN--FEFVHGDIR 60 Query: 72 DRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVS-KF 130 ++ + ++ +Y DS H AG A+ S P + N+ GT+ LLE ++QYN + Sbjct: 61 NKNDVTRLITKYMPDSCFHLAGQVAMTTSIDNPCMDFEINVGGTLNLLEAVRQYNSNCNI 120 Query: 131 VFSSSATVYGDATRF------------PNMIPIPEECPLGPTNPYGHTKYAIENILNDLY 178 ++SS+ VYGD ++ E L +PYG +K A + + D Sbjct: 121 IYSSTNKVYGDLEQYKYNETETRYTCVDKPNGYDESTQLDFHSPYGCSKGAADQYMLDY- 179 Query: 179 NSDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYD 238 + + R+ + G + +G ++ G + I G Sbjct: 180 -ARIFGLNTVVFRHSSMYGGRQFATYDQGWVGW---FCQKAVEIKNGINKPFTISG---- 231 Query: 239 SRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSG--KGSTVFEVYHAFC 296 +G +RD +H D+ + AL + N +N+G ++ E++ Sbjct: 232 --NGKQVRDVLHAEDMISLYFTALANVSKIRGNA-----FNIGGTIVNSLSLLELFKLLE 284 Query: 297 KASGIDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTE 350 ID+ + R D A + + W ++ +D + ++ WT+ Sbjct: 285 DYCNIDMRFTNLPVRESDQRVFVADIKKITNAIDWSPKVSAKDGVQKMYDWTSS 338 >1N7G-A nrPDB Length = 381 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 75/348 (21%), Positives = 129/348 (37%), Gaps = 38/348 (10%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVL-------TKHHI 63 KI L+TG G GS+ L+ GY+ V + S+ + R+ + K + Sbjct: 28 RKIALITGITGQDGSYLTEFLLGKGYE--VHGLIRRSSNFNTQRINHIYIDPHNVNKALM 85 Query: 64 PFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQ 123 + DL D L + K D V + A V S +IP G + LLE ++ Sbjct: 86 KLHYADLTDASSLRRWIDVIKPDEVYNLAAQSHVAVSFEIPDYTADVVATGALRLLEAVR 145 Query: 124 QYNVS-----KFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLY 178 + + K+ + S+ ++G P E P P +PY +K A + Sbjct: 146 SHTIDSGRTVKYYQAGSSEMFGSTPP-----PQSETTPFHPRSPYAASKCAAHWYTVNYR 200 Query: 179 NSDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYD 238 + + + + H S GE + + + ++ VG + KL++ G+ Sbjct: 201 EA------YGLFACNGILFNHESPRRGE--NFVTRKITRALGRIKVGLQTKLFL-GNLQA 251 Query: 239 SRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKA 298 SRD DY+ + L Y+ A E + ++ G ++ Y Sbjct: 252 SRDWGFAGDYVEAMWLMLQQEKPDDYVVATEEGHTVEEFLDVSFGYLGLNWKDY------ 305 Query: 299 SGIDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWK 346 ID Y R +V NL +AK L W+ ++ E K + Sbjct: 306 VEIDQRY----FRPAEVDNLQGDASKAKEVLGWKPQVGFEKLVKMMVD 349 >5UZH-A nrPDB Length = 345 Score = 240 bits (612), Expect = 2e-63, Method: Composition-based stats. Identities = 74/364 (20%), Positives = 138/364 (37%), Gaps = 55/364 (15%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVA----DNLSNSTYDSVARLEVLTKHHIPFY 66 SK+ L+TG G GS+ L+E GY + + + + + +TK Sbjct: 1 SKVALITGITGQDGSYLAEFLLEKGYMVYGIIRRSSSFNTGRVEHLYKDIHITKAKFKLL 60 Query: 67 EVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN 126 DL D L + + K D + + A V S ++P + + +GT+ LLE ++ Sbjct: 61 YGDLTDTGNLISIIAKIKPDEIYNLAAQSHVKVSFEMPEYTANVDGIGTLRLLEAIRACG 120 Query: 127 V---SKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKK 183 + +KF +S++ +YG +P E P P +PY K I+ + + Sbjct: 121 LEKKTKFYQASTSELYG----LVQEVPQKETTPFYPRSPYACAKLYSYWIVVNYREAYNM 176 Query: 184 SWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGT 243 IL FN H S G P + + +A++ +G ++ LY+ G+ RD Sbjct: 177 FALNGIL--FN----HESIRRG--PTFVTRKITMAVARIKLGLQDCLYL-GNLDAERDWG 227 Query: 244 PIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDL 303 +DY+ + L + R++ + +G+ +V E G + Sbjct: 228 HAKDYVEAMWLML--------------QQEQPRDFCVATGEKHSVREFVEKAFACIGQTV 273 Query: 304 PYK---------------------VTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCK 342 +K R +V L P A+ L W+ ++ E+ + Sbjct: 274 EWKGERGTVEEHGVVDGVVRVRVDPRYFRPTEVDQLLGDPTLAETVLGWKRKVSFEELVR 333 Query: 343 DLWK 346 + + Sbjct: 334 GMVE 337 >6GPK-A nrPDB Length = 373 Score = 240 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 75/373 (20%), Positives = 141/373 (37%), Gaps = 36/373 (9%) Query: 2 TAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKH 61 T L +S + L+TG G GS+ L+E GY+ + S+ + R+E L K+ Sbjct: 15 TENLYFQSMRNVALITGITGQDGSYLAEFLLEKGYEVHGI--VRRSSSFNTGRIEHLYKN 72 Query: 62 -------HIPFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILG 114 ++ + DL D L K+ E K + + V S + + +G Sbjct: 73 PQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVG 132 Query: 115 TVVLLELMQQY---NVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIE 171 T+ LL+ ++ N KF +S++ +YG IP E P P +PYG K Sbjct: 133 TLRLLDAVKTCGLINSVKFYQASTSQLYGKVQE----IPQKETTPFYPRSPYGAAKLYAY 188 Query: 172 NILNDLYNSDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLY 231 I+ + + IL FN H S G + + +A++ +G+ E Sbjct: 189 WIVVNFREAYNLFAVNGIL--FN----HESPRRG--ANFVTRKISRSVAKIYLGQLECFS 240 Query: 232 IFGDDYDSRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCR-----EWNLGSGK-- 284 + G+ RD +DY+ + L + ++ A E + ++G Sbjct: 241 L-GNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVW 299 Query: 285 GSTVFEVYHAFCKASGIDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDL 344 + + + + R +V L +AK++L W+ + ++ +++ Sbjct: 300 EGKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREM 359 Query: 345 ----WKWTTENPF 353 + NP Sbjct: 360 VHADVELMRTNPN 372 >3RUE-A nrPDB Length = 351 Score = 239 bits (610), Expect = 3e-63, Method: Composition-based stats. Identities = 94/357 (26%), Positives = 154/357 (43%), Gaps = 37/357 (10%) Query: 1 MTAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTK 60 +T QL + K L+TG AG+IGS+ + +L++ + DN S ++ ++ L Sbjct: 17 ITQQLIF--SPKTWLITGVAGFIGSNLLEKLLKLNQVVIGLDNFSTGHQYNLDEVKTLVS 74 Query: 61 ----HHIPFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTV 116 F E D+ D E+V K +D V+H A L +V S P+ NI G + Sbjct: 75 TEQWSRFCFIEGDIRDLTTCEQVMK--GVDHVLHQAALGSVPRSIVDPITTNATNITGFL 132 Query: 117 VLLELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILND 176 +L + V F +++S++ YGD P + EE P +PY TKY + I Sbjct: 133 NILHAAKNAQVQSFTYAASSSTYGDHPALPKV----EENIGNPLSPYAVTKY-VNEIYAQ 187 Query: 177 LYNSDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDD 236 +Y + +K LRYFN G +DP G ++P A+ + + +YI GD Sbjct: 188 VY-ARTYGFKTIGLRYFNVFGRR------QDPNGAYAAVIPKWT-AAMLKGDDVYINGDG 239 Query: 237 YDSRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFE----VY 292 SRD I + I + L A ++ +N+ G +T+ E +Y Sbjct: 240 ETSRDFCYIDNVIQ-----------MNILSALAKDSAKDNIYNVAVGDRTTLNELSGYIY 288 Query: 293 HAFCKASGID-LPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWT 348 ID L K R+GDV + A +A LK++ +++ + + W Sbjct: 289 DELNLIHHIDKLSIKYREFRSGDVRHSQADVTKAIDLLKYRPNIKIREGLRLSMPWY 345 >2Z95-A nrPDB Length = 345 Score = 238 bits (607), Expect = 6e-63, Method: Composition-based stats. Identities = 72/359 (20%), Positives = 140/359 (38%), Gaps = 50/359 (13%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 + K L+TG G G++ L+E GY+ AD + + S E+ ++ + +D Sbjct: 2 SGKRALITGIRGQDGAYLAKLLLEKGYEVYGADR-RSGEFASWRLKELGIENDVKIIHMD 60 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVS- 128 L + + + ++ + D V + A VG S + P+ + +G + +LE ++ Sbjct: 61 LLEFSNIIRTIEKVQPDEVYNLAAQSFVGVSFEQPILTAEVDAIGVLRILEALRTVKPDT 120 Query: 129 KFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFA 188 KF +S++ ++G IP E+ P P +PY K I + + Sbjct: 121 KFYQASTSEMFGKVQE----IPQTEKTPFYPRSPYAVAKLFGHWITVNYREAYNMFACSG 176 Query: 189 ILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDY 248 IL FN H S L G + + + +A++ G ++KL + G+ RD +Y Sbjct: 177 IL--FN----HESPLRGIE--FVTRKITYSLARIKYGLQDKL-VLGNLNAKRDWGYAPEY 227 Query: 249 IHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYKVT 308 + + L Y+ + +G+ TV E K +G D+ + Sbjct: 228 VEAMWLMMQQPEPDDYV--------------IATGETHTVREFVEKAAKIAGFDIEWVGE 273 Query: 309 G---------------------RRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWK 346 G R +V L P++A ++L W+ ++ + + + Sbjct: 274 GINEKGIDRNTGKVIVEVSEEFFRPAEVDILVGNPEKAMKKLGWKPRTTFDELVEIMME 332 >3IMH-A nrPDB Length = 338 Score = 238 bits (606), Expect = 8e-63, Method: Composition-based stats. Identities = 68/341 (19%), Positives = 136/341 (39%), Gaps = 50/341 (14%) Query: 376 VTIGAGTRFQATFANLGASIVDLKVNGQSVVLGYENEEGYLNPDSAYIGATIGRYANRIS 435 +T+ N GA++ + ++G++++L + E Y + + ++G T+GR A R+ Sbjct: 21 ITLENDAGMAVKVLNYGATLEKVLLDGENMILSLNSPEDY-SKERNFLGGTVGRIAGRVR 79 Query: 436 KGKFSLCNKDYQLTVNNGVNANHSSIGS-FHRKRFLGPIIQNPSKDVFT--AEYMLIDNE 492 G++ N+ +QL +N+G N H IG+ H F PS D + L D + Sbjct: 80 AGQWKHGNEIHQLPLNDGDNHIHGGIGTDMHVWDF------RPSCDSEHARVDLTLFDPD 133 Query: 493 KDTEFPGDLLVTIQYTVNVAQKSLEMVYKGKLTAGEATPINLTNHSYFNLNKPYGDTIEG 552 + ++PG+L + +Y ++ + Y + + + T N NH+YFNL G+ E Sbjct: 134 GNNDYPGNLKLHARYELDNENN---LHYLLEAVSDKLTIFNPVNHTYFNL----GERAED 186 Query: 553 TEIMVRSKKSVDVDKNMIPTGNIVDREIATFNSTKPTVLG----PKNPQF------DCCF 602 + + + + VD+ +P + + F+ K +G + Q D F Sbjct: 187 LNLQMNADYYLPVDEAGLPDRGMAEVAGTAFDFRKTKRIGDALNSDDSQIKLRNGLDHPF 246 Query: 603 VVDENAKPSQINTLNNELTLIVKAFHPDSNITLEVLSTEPTYQFYTGDFLSAG-----YE 657 +++ N + +++ + L V + P Y G+ + Sbjct: 247 ILNGNNPAALLSSNKHRLI---------------VKTNAPALVLYAGNHFNHTGIVNNIG 291 Query: 658 ARQGFAIEPGRYIDAINQENWKDCVTLKNGETYGSKIVYRF 698 G E N +TL E + + ++F Sbjct: 292 QYDGITFEAQCPPAEGND---LGQITLLPFEKFKRTVDWKF 329 >1OC2-A nrPDB Length = 348 Score = 237 bits (605), Expect = 1e-62, Method: Composition-based stats. Identities = 87/372 (23%), Positives = 146/372 (39%), Gaps = 45/372 (12%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTY-DSVARLEVLTKHHIPFY 66 S K ++VTGGAG+IGS+ V + N + V L TY + A LE + + Sbjct: 1 MSQFKNIIVTGGAGFIGSNFV-HYVYNNHPDVHVTVLDKLTYAGNKANLEAILGDRVELV 59 Query: 67 EVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN 126 D+ D + ++K+ K D+++H+A S P + H N +GT LLE ++Y+ Sbjct: 60 VGDIADAELVDKLAA--KADAIVHYAAESHNDNSLNDPSPFIHTNFIGTYTLLEAARKYD 117 Query: 127 VSKFVFSSSATVYGDATRFPNMIPIPE--------ECPLGPTNPYGHTKYAIENILNDLY 178 + +F S+ VYGD ++ E E P++PY TK A + I+ Sbjct: 118 I-RFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETNYNPSSPYSSTKAASDLIVKAW- 175 Query: 179 NSDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPY-MAQVAVGRREKLYIFGDDY 237 +R F + P +P + + G + KLY Sbjct: 176 -----------VRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILAGIKPKLY------ 218 Query: 238 DSRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCK 297 +G +RD+IH D + G A L + + +G+ EV + Sbjct: 219 --GEGKNVRDWIHTNDHSTGVWAIL-------TKGRMGETYLIGADGEKNNKEVLELILE 269 Query: 298 ASGIDL-PYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQ-VEDSCKDLWKWTTENPFGY 355 G Y RAG L + + EL W + + ++ +W T+N + Sbjct: 270 KMGQPKDAYDHVTDRAGHDLRYAIDASKLRDELGWTPQFTDFSEGLEETIQWYTDNQDWW 329 Query: 356 QL--RGVEARFS 365 + VEA ++ Sbjct: 330 KAEKEAVEANYA 341 >1RKX-A nrPDB Length = 357 Score = 236 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 75/352 (21%), Positives = 131/352 (37%), Gaps = 35/352 (9%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 K V VTG G+ G + L G V +L+ T S+ + + D Sbjct: 8 QGKRVFVTGHTGFKGGWLSLWLQTMG-ATVKGYSLTAPTVPSLFETARVADG-MQSEIGD 65 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSK 129 + D+ L + +E++ + V H A V S P+ Y N++GTV LLE ++ K Sbjct: 66 IRDQNKLLESIREFQPEIVFHMAAQPLVRLSYSEPVETYSTNVMGTVYLLEAIRHVGGVK 125 Query: 130 -FVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSD------- 181 V +S Y + + E +G +PY ++K E + + NS Sbjct: 126 AVVNITSDKCYDNKEW---IWGYRENEAMGGYDPYSNSKGCAELVTSSYRNSFFNPANYG 182 Query: 182 KKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRD 241 + A +R N IG G D ++P + + A + + + I R+ Sbjct: 183 QHGTAVATVRAGNVIG---GGDWALD------RIVPDILR-AFEQSQPVII-------RN 225 Query: 242 GTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLG--SGKGSTVFEVYHAFCKAS 299 IR + HV++ G++ Q L Y + WN G + V + K Sbjct: 226 PHAIRPWQHVLEPLSGYLLLAQKL--YTDGAEYAEGWNFGPNDADATPVKNIVEQMVKYW 283 Query: 300 GIDLPYKVTGR-RAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTE 350 G +++ G + L +AK +L W + + + + W Sbjct: 284 GEGASWQLDGNAHPHEAHYLKLDCSKAKMQLGWHPRWNLNTTLEYIVGWHKN 335 >2Q1T-A nrPDB Length = 377 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 88/355 (24%), Positives = 147/355 (41%), Gaps = 35/355 (9%) Query: 7 SESTSKIVLVTGGAGYIGSHTVVELIENGYDCV-VADNLSNSTYDSVARLEVLTKHHIPF 65 S+ + V+V GGAG++GS+ V L+E G + V V DNL S ++ V + F Sbjct: 28 SKLANTNVMVVGGAGFVGSNLVKRLLELGVNQVHVVDNLL-----SAEKINVPDHPAVRF 82 Query: 66 YEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQY 125 E + D L + EY D V H A S PL + NN L T+ L E ++ + Sbjct: 83 SETSITDDALLASLQDEY--DYVFHLATYHGNQSSIHDPLADHENNTLTTLKLYERLKHF 140 Query: 126 N-VSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTN---PYGHTKYAIENILNDLYNSD 181 + K V+S++ + T F + E + N PY +K E +Y Sbjct: 141 KRLKKVVYSAAGCSIAEKT-FDDAKATEETDIVSLHNNDSPYSMSKIFGEFY--SVYYHK 197 Query: 182 KKSWKFAILRYFNPIGAHP---SGLIGEDPLGIPNNLLP-YMAQVAVGRREKLYIFGDDY 237 + R+ N G +G P + N+ P ++ + G L Sbjct: 198 QHQLPTVRARFQNVYGPGEILGAGRWRGTPATVWRNVTPTFIYKALKGMPLPL------- 250 Query: 238 DSRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCK 297 G RD+I V D+A G IA A + G +N+ SGK +++ ++ + Sbjct: 251 -ENGGVATRDFIFVEDVANGLIAC-----AADGTPG--GVYNIASGKETSIADLATKINE 302 Query: 298 ASGIDLPYKVTGRRAGDVLNLT-AKPDRAKRELKWQTELQVEDSCKDLWKWTTEN 351 +G + +R D P++A+REL + ++ ++D + +WT N Sbjct: 303 ITGNNTELDRLPKRPWDNSGKRFGSPEKARRELGFSADVSIDDGLRKTIEWTKAN 357 >2PK3-A nrPDB Length = 321 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 68/343 (19%), Positives = 133/343 (38%), Gaps = 37/343 (10%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 S L+TG AG++G + L E + ++ ++ A+L ++ +D+ Sbjct: 12 SMRALITGVAGFVGKYLANHLTEQNVEVF------GTSRNNEAKLP-----NVEMISLDI 60 Query: 71 CDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVS-K 129 D + ++KV + K D + H A +V +S + N+ GT+ +L+ ++ N+ + Sbjct: 61 MDSQRVKKVISDIKPDYIFHLAAKSSVKDSWLNKKGTFSTNVFGTLHVLDAVRDSNLDCR 120 Query: 130 FVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAI 189 + S+ YG P P+ EE L P +PYG +K ++ + Sbjct: 121 ILTIGSSEEYG--MILPEESPVSEENQLRPMSPYGVSKASVGMLARQY--VKAYGMDIIH 176 Query: 190 LRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYI 249 R FN IG G+ + + + + + ++E + G+ RD T +RD + Sbjct: 177 TRTFNHIGP------GQSLGFVTQDFAKQIVDIEMEKQEPIIKVGNLEAVRDFTDVRDIV 230 Query: 250 HVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASG--IDLPYKV 307 L + +N+ SG G+ + +V + ID Sbjct: 231 QAYWLLSQY-------------GKTGDVYNVCSGIGTRIQDVLDLLLAMANVKIDTELNP 277 Query: 308 TGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTE 350 R +V L R K W+ + +E S ++ + + Sbjct: 278 LQLRPSEVPTLIGSNKRLKDSTGWKPRIPLEKSLFEILQSYRQ 320 >2PZM-A nrPDB Length = 330 Score = 217 bits (553), Expect = 1e-56, Method: Composition-based stats. Identities = 76/346 (21%), Positives = 136/346 (39%), Gaps = 54/346 (15%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 + +L+TGGAG +GS+ + + G++ +V DN + + + + L+ E Sbjct: 19 SHMRILITGGAGCLGSNLIEHWLPQGHEILVIDNFATGKREVLPPVAGLS-----VIEGS 73 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYH---NNILGTVVLLELMQQYN 126 + D LE+ F +K V+H A + + P + N+ G++ + + + Sbjct: 74 VTDAGLLERAFDSFKPTHVVHSAA------AYKDPDDWAEDAATNVQGSINVAKAASKAG 127 Query: 127 VSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWK 186 V + + +A YG P +PIP + P P YG +K A E L Sbjct: 128 VKRLLNFQTALCYGR----PATVPIPIDSPTAPFTSYGISKTAGEAFLM------MSDVP 177 Query: 187 FAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIR 246 LR N G P IG P + ++ G++ F D +R Sbjct: 178 VVSLRLANVTG--PRLAIGPIPT--------FYKRLKAGQK----CFCSDT-------VR 216 Query: 247 DYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDL--P 304 D++ + D IA L E +N+ +G+G ++ EV+ G L P Sbjct: 217 DFLDMSDFLA--IADLSLQEGRPTG-----VFNVSTGEGHSIKEVFDVVLDYVGATLAEP 269 Query: 305 YKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTE 350 V A DV ++ P + + E W+ ++ +D+ W + Sbjct: 270 VPVVAPGADDVPSVVLDPSKTETEFGWKAKVDFKDTITGQLAWYDK 315 >1RPN-A nrPDB Length = 335 Score = 215 bits (548), Expect = 4e-56, Method: Composition-based stats. Identities = 74/344 (21%), Positives = 139/344 (40%), Gaps = 35/344 (10%) Query: 9 STSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLT-KHHIPFYE 67 S ++ LVTG G G++ L+E GY V ++ + D+ RL L + I + + Sbjct: 12 SMTRSALVTGITGQDGAYLAKLLLEKGYR--VHGLVARRSSDTRWRLRELGIEGDIQYED 69 Query: 68 VDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNV 127 D+ D +++ + + V + A VG S P+ + LG LLE ++Q++ Sbjct: 70 GDMADACSVQRAVIKAQPQEVYNLAAQSFVGASWNQPVTTGVVDGLGVTHLLEAIRQFSP 129 Query: 128 -SKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWK 186 ++F +S++ ++G E P P +PYG K I + S Sbjct: 130 ETRFYQASTSEMFG----LIQAERQDENTPFYPRSPYGVAKLYGHWITVNYRESFGLHAS 185 Query: 187 FAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIR 246 IL FN H S L G + + + +A++ +G++++L + G+ RD Sbjct: 186 SGIL--FN----HESPLRGIE--FVTRKVTDAVARIKLGKQQELRL-GNVDAKRDWGFAG 236 Query: 247 DYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGID---- 302 DY+ + L A Y+ A + ++ + G+D Sbjct: 237 DYVEAMWLMLQQDKADDYVVATGVTTTV--------------RDMCQIAFEHVGLDYRDF 282 Query: 303 LPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWK 346 L R +V L P +A+R L W+ +++ + + + Sbjct: 283 LKIDPAFFRPAEVDVLLGNPAKAQRVLGWKPRTSLDELIRMMVE 326 >2Q1W-A nrPDB Length = 333 Score = 200 bits (508), Expect = 2e-51, Method: Composition-based stats. Identities = 70/348 (20%), Positives = 132/348 (37%), Gaps = 55/348 (15%) Query: 9 STSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEV 68 S K V +TG G IGSH L+E G V DN + + + ++ F E Sbjct: 19 SHMKKVFITGICGQIGSHIAELLLERGDKVVGIDNFATGRREHLK-----DHPNLTFVEG 73 Query: 69 DLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYH---NNILGTVVLLELMQQY 125 + D + ++ + + D+V+H A S + P +Y+ N +G +++ ++ Sbjct: 74 SIADHALVNQLIGDLQPDAVVHTAA------SYKDPDDWYNDTLTNCVGGSNVVQAAKKN 127 Query: 126 NVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTN-PYGHTKYAIENILNDLYNSDKKS 184 NV +FV+ +A YG P P+ + P P N Y +K A E+ L + Sbjct: 128 NVGRFVYFQTALCYGVK---PIQQPVRLDHPRNPANSSYAISKSANEDYL------EYSG 178 Query: 185 WKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTP 244 F R N +G P + G P+ + +K ++ Sbjct: 179 LDFVTFRLANVVG--PRNVSGPLPIFFQR----------LSEGKKCFVT---------KA 217 Query: 245 IRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDL- 303 RD++ V DLA+ + A+ + ++ SG + E+Y A +A + Sbjct: 218 RRDFVFVKDLARATVRAVDGV--------GHGAYHFSSGTDVAIKELYDAVVEAMALPSY 269 Query: 304 -PYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTE 350 ++ D ++ P R ++ ++++ + E Sbjct: 270 PEPEIRELGPDDAPSILLDPSRTIQDFGKIEFTPLKETVAAAVAYFRE 317 >1GFS-A nrPDB Length = 321 Score = 198 bits (503), Expect = 8e-51, Method: Composition-based stats. Identities = 72/360 (20%), Positives = 129/360 (35%), Gaps = 54/360 (15%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 + + V + G G +GS +L + G +V E++ Sbjct: 2 SKQRVFIAGHRGMVGSAIRRQLEQRGDVELVLRTRD---------------------ELN 40 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAGL-KAVGESTQIPLRYYHNNILGTVVLLELMQQYNVS 128 L D + + F +ID V A + + P + + N++ ++ Q +V+ Sbjct: 41 LLDSRAVHDFFASERIDQVYLAAAKVGGIVANNTYPADFIYQNMMIESNIIHAAHQNDVN 100 Query: 129 KFVFSSSATVYGDATRFPNMIPIPEECPLGPTN-PYGHTKYA---IENILNDLYNSDKKS 184 K +F S+ +Y + P + L PTN PY K A + N Y D +S Sbjct: 101 KLLFLGSSCIYPKLAKQPMAESELLQGTLEPTNEPYAIAKIAGIKLCESYNRQYGRDYRS 160 Query: 185 WKFAILRYFNPIGAHPSGLIGEDPLGIPNN------LLPYMAQVAVGRREKLYIFGDDYD 238 P+ L G P+N LL + + ++G Sbjct: 161 V-------------MPTNLYGPHDNFHPSNSHVIPALLRRFHEATAQNAPDVVVWGS--- 204 Query: 239 SRDGTPIRDYIHVVDLAKGHIAALQYL-EAYNEN-EGLCREWNLGSGKGSTVFEVYHAFC 296 GTP+R+++HV D+A I ++ E + EN + + N+G+G T+ E+ Sbjct: 205 ---GTPMREFLHVDDMAAASIHVMELAHEVWLENTQPMLSHINVGTGVDCTIRELAQTIA 261 Query: 297 KASGIDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQ 356 K G + R +L W E+ +E ++W EN ++ Sbjct: 262 KVVGYKGRVVFDASKPDGTPRKLLDVTRLH-QLGWYHEISLEAGLASTYQWFLENQDRFR 320 >2X86-A nrPDB Length = 357 Score = 192 bits (487), Expect = 5e-49, Method: Composition-based stats. Identities = 79/352 (22%), Positives = 141/352 (40%), Gaps = 62/352 (17%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGY-DCVVADNLSNST-YDSVARLEV---LTKHHIPFY 66 ++++VTGGAG+IGS+ V L + G D +V DNL + T + ++ L + + K Sbjct: 47 RMIIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDGTKFVNLVDLNIADYMDKEDFLIQ 106 Query: 67 EVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN 126 + + +E +F E S + G + + Q Y +L + E+ Sbjct: 107 IMAGEEFGDVEAIFHEGACSSTTEWDGKYMMDNNYQ-----YSKELLHYCLEREI----- 156 Query: 127 VSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWK 186 F+++SSA YG T + I E P N +G++K+ + + + + + + Sbjct: 157 --PFLYASSAATYGGRT--SDFIESREYE--KPLNVFGYSKFLFDEYVRQI--LPEANSQ 208 Query: 187 FAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIR 246 RYFN G + N Q+ G KL+ +++ R Sbjct: 209 IVGFRYFNVYGPREGHKGSMASVAFHLN-----TQLNNGESPKLFEGSENFK-------R 256 Query: 247 DYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEV------YHAFCKASG 300 D+++V D+A + L +LE G+ +NLG+G+ + V YH + Sbjct: 257 DFVYVGDVADVN---LWFLE-----NGVSGIFNLGTGRAESFQAVADATLAYHKKGQIEY 308 Query: 301 IDLPYKVTGR----RAGDVLNLTAKPDRAKRELKW-QTELQVEDSCKDLWKW 347 I P K+ GR D+ NL A + + V + + W Sbjct: 309 IPFPDKLKGRYQAFTQADLTNLRAA--------GYDKPFKTVAEGVTEYMAW 352 >1EQ2-A nrPDB Length = 310 Score = 192 bits (487), Expect = 5e-49, Method: Composition-based stats. Identities = 80/351 (22%), Positives = 140/351 (39%), Gaps = 62/351 (17%) Query: 13 IVLVTGGAGYIGSHTVVELIENGY-DCVVADNLSNST-YDSVARLEV---LTKHHIPFYE 67 +++VTGGAG+IGS+ V L + G D +V DNL + T + ++ L + + K Sbjct: 1 MIIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDGTKFVNLVDLNIADYMDKEDFLIQI 60 Query: 68 VDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNV 127 + + +E +F E S + G + + Q Y +L + E+ Sbjct: 61 MAGEEFGDVEAIFHEGACSSTTEWDGKYMMDNNYQ-----YSKELLHYCLEREI------ 109 Query: 128 SKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKF 187 F+++SSA YG T + I E P N YG++K+ + + + + + + Sbjct: 110 -PFLYASSAATYGGRT--SDFIESREYE--KPLNVYGYSKFLFDEYVRQI--LPEANSQI 162 Query: 188 AILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRD 247 RYFN G + N Q+ G KL+ +++ RD Sbjct: 163 VGFRYFNVYGPREGHKGSMASVAFHLN-----TQLNNGESPKLFEGSENFK-------RD 210 Query: 248 YIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEV------YHAFCKASGI 301 +++V D+A + L +LE G+ +NLG+G+ + V YH + I Sbjct: 211 FVYVGDVADVN---LWFLE-----NGVSGIFNLGTGRAESFQAVADATLAYHKKGQIEYI 262 Query: 302 DLPYKVTGR----RAGDVLNLTAKPDRAKRELKW-QTELQVEDSCKDLWKW 347 P K+ GR D+ NL A + + V + + W Sbjct: 263 PFPDKLKGRYQAFTQADLTNLRAA--------GYDKPFKTVAEGVTEYMAW 305 >3SXP-A nrPDB Length = 362 Score = 185 bits (468), Expect = 9e-47, Method: Composition-based stats. Identities = 76/357 (21%), Positives = 142/357 (39%), Gaps = 62/357 (17%) Query: 5 LQSESTSKIVLVTGGAGYIGSHTVVELIENGY--DCVVADNLSNSTYDSVARLEVLT--K 60 + E ++ +L+TGGAG++GS+ EN VV D ++T S R L K Sbjct: 4 IDDELENQTILITGGAGFVGSNLAFHFQENHPKAKVVVLDKFRSNTLFSNNRPSSLGHFK 63 Query: 61 HHIPF----YEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTV 116 + I F D+ + L ++ ++ D + H A + + N + Sbjct: 64 NLIGFKGEVIAADINNPLDLRRL-EKLHFDYLFHQAAVS--DTTMLNQELVMKTNYQAFL 120 Query: 117 VLLELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILND 176 LLE+ + +K +++SSA VYG+ T+ PN++ E P N YG +K ++ + Sbjct: 121 NLLEIARS-KKAKVIYASSAGVYGN-TKAPNVVGKNE----SPENVYGFSKLCMDEFVLS 174 Query: 177 LYNSDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVG----RREKLYI 232 N + + LRYFN G + Q+A+G + KL+ Sbjct: 175 HSNDNVQ----VGLRYFNVYGPRE---------FYKEKTASMVLQLALGAMAFKEVKLFE 221 Query: 233 FGDDYDSRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVY 292 FG+ +RD++++ D+ + ++ A++ + +N+G + + E+ Sbjct: 222 FGE--------QLRDFVYIEDVIQANVKAMKAQK--------SGVYNVGYSQARSYNEIV 265 Query: 293 HAF------CKASGIDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKD 343 K + I PY + A + +L + +E KD Sbjct: 266 SILKEHLGDFKVTYIKNPYAFFQKHT------QAHIEPTILDLDYTPLYDLESGIKD 316 >4EJ0-A nrPDB Length = 342 Score = 179 bits (453), Expect = 5e-45, Method: Composition-based stats. Identities = 76/360 (21%), Positives = 137/360 (38%), Gaps = 59/360 (16%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVV-ADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 ++VTG AG+IG++ V L E G ++ DNL+ + + + L I D Sbjct: 13 MTLIVTGAAGFIGANLVKALNERGETRIIAVDNLTRAD-----KFKNLVDCEID----DY 63 Query: 71 CDRKGLEKVFKE---YKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVV-LLELMQQYN 126 D+ + F K+ +V H ++ + RY +N +L+ Sbjct: 64 LDKTEFVERFARGDFGKVRAVFHEGA---CSDTMETDGRYMMDNNFRYSRAVLDACLAQG 120 Query: 127 VSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWK 186 ++F+++SSA +YG ++RF + E P N YG++K+ + ++ + K + Sbjct: 121 -AQFLYASSAAIYGGSSRF-----VEEREVEAPLNVYGYSKFLFDQVIRRVMPGAKS--Q 172 Query: 187 FAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIR 246 A RYFN G S + N + A+ K+ +FG+ G R Sbjct: 173 IAGFRYFNVYGPRESHKGRMASVAFH-NFNQFRAE------GKVKLFGEYSGYGPGEQTR 225 Query: 247 DYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFE----VYHAFCKASGID 302 D++ V D+AK ++ Y + E G +NLG+G+ + V + G Sbjct: 226 DFVSVEDVAKVNL----YFFDHPEKSG---IFNLGTGRAQPFNDIAATVVNTLRALEGQP 278 Query: 303 LPYKVTGRRAGDVLNL--------------TAKPDRAKRELKWQ-TELQVEDSCKDLWKW 347 G V + A + R + L V++ +W Sbjct: 279 ALTLAEQVEQGLVEYVPFPDALRGKYQCFTQADQTKL-RAAGYDAPFLTVQEGVDRYVRW 337 >3M2P-A nrPDB Length = 311 Score = 178 bits (452), Expect = 6e-45, Method: Composition-based stats. Identities = 73/336 (21%), Positives = 133/336 (39%), Gaps = 48/336 (14%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 S + VTGG G++G + V + +G ++ + I YE Sbjct: 1 MSLKIAVTGGTGFLGQYVVESIKNDGNTPIILTR-------------SIGNKAINDYEYR 47 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSK 129 + D + + + +D+V+H A + +Q + +H+N + T L + + N+S Sbjct: 48 VSDYTLEDLINQLNDVDAVVHLAATRG----SQGKISEFHDNEILTQNLYDACYENNISN 103 Query: 130 FVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAI 189 V++S+ + Y D T P +E PL P YG +K A E+I N S KK Sbjct: 104 IVYASTISAYSDETSLP---WNEKELPL-PDLMYGVSKLACEHIGNIY--SRKKGLCIKN 157 Query: 190 LRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYI 249 LR+ + G + + + Q G + L+ + R+++ Sbjct: 158 LRFAHLYGFNEKNNY---------MINRFFRQAFHGEQLTLH--------ANSVAKREFL 200 Query: 250 HVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYKVTG 309 + D AK I AL+ E + +N+GSG T +EV + A G V Sbjct: 201 YAKDAAKSVIYALK-------QEKVSGTFNIGSGDALTNYEVANTINNAFGNKDNLLVKN 253 Query: 310 RRAGD-VLNLTAKPDRAKRELKWQTELQVEDSCKDL 344 A + + + +AK L + T+ + +++ Sbjct: 254 PNANEGIHSSYMDSSKAKELLDFSTDYNFATAVEEI 289 >4BZF-A nrPDB Length = 324 Score = 171 bits (433), Expect = 8e-43, Method: Composition-based stats. Identities = 62/310 (20%), Positives = 114/310 (36%), Gaps = 39/310 (12%) Query: 394 SIVDLKVNGQSVVLGYENEEGYLNPDSAYIGATIGRYANRISKGKFSLCNKDYQLTVNNG 453 S+VD N Q ++ E E + + + Y G I NRIS G FS + Y +N Sbjct: 36 SLVDKTTNVQ-LLREPETAESFHDTPTLY-GIPILFPPNRISDGTFSFRGRTYHFDINEK 93 Query: 454 VNANHSSIGSFHRKRFLGPIIQNPSKDVFTAEYMLID-NEKDTEFPGDLLVTIQYTV--N 510 NH +H K + Q + E L + +FP +V + YT+ N Sbjct: 94 DKHNHLHGFLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKEN 153 Query: 511 VAQKSLEMVYKGKLTAGEATPINLTNHSYFNLNKPYGDTIEGTEIMVRSKKSVDVDKNMI 570 K ++ KGK EA P + H+ F E + + + + ++D+ ++ Sbjct: 154 TLFKHATVMNKGK----EAFPWGIGYHTTFIF------PAESSLFSLTADQQWELDERLL 203 Query: 571 PTGNIVDREIATFNSTKPTVLGPKNPQFDCCFVVDENAKPSQINTLNNELTLIVKAFHPD 630 PTG ++D + + ++ Q D F+ + + + +H Sbjct: 204 PTGKLMDV---PYKEALHEGMDLRHKQLDDVFLSSYQKRGGENQAV---------IYHQH 251 Query: 631 SNITLEVLSTEPTYQ--FYTGDFLSAGYEARQGFAIEPGRYIDAINQENWKDCVT----L 684 ++I++ + E Y D + EP ++ + +T L Sbjct: 252 AHISIIYKADEQFKHWVVYNAD------GKQGYLCPEPYTWVTNAVNLDLPSSLTGLQVL 305 Query: 685 KNGETYGSKI 694 + GE +K Sbjct: 306 EPGEETTAKS 315 >2C54-A nrPDB Length = 379 Score = 137 bits (345), Expect = 1e-32, Method: Composition-based stats. Identities = 61/360 (16%), Positives = 125/360 (34%), Gaps = 40/360 (11%) Query: 6 QSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHI-- 63 S + + +TG G+I SH L G+ + +D + E +T+ Sbjct: 24 YWPSENLKISITGAGGFIASHIARRLKHEGHYVIASD---------WKKNEHMTEDMFCD 74 Query: 64 PFYEVDLCDRKGLEKVFKEYKIDSVIHFAG-LKAVGESTQIPLRYYHNNILGTVVLLELM 122 F+ VDL + KV +D V + A + +G +NN + + ++E Sbjct: 75 EFHLVDLRVMENCLKV--TEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAA 132 Query: 123 QQYNVSKFVFSSSATVYGDATRFPNM-IPIPEEC--PLGPTNPYGHTKYAIENILNDLYN 179 + + +F ++SSA +Y + + + + E P P + YG + A E + Sbjct: 133 RINGIKRFFYASSACIYPEFKQLETTNVSLKESDAWPAEPQDAYGLERLATEELCKHYNK 192 Query: 180 SDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDS 239 + R+ N G + G + A ++ ++G Sbjct: 193 DFGIECRIG--RFHNIYGPFGTWKGGR------EKAPAAFCRKAQTSTDRFEMWG----- 239 Query: 240 RDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKAS 299 DG R + + + +G + N+GS + ++ E+ Sbjct: 240 -DGLQTRSFTFIDECVEGVLRL--------TKSDFREPVNIGSDEMVSMNEMAEMVLSFE 290 Query: 300 GIDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQLRG 359 LP G V + + K +L W +++++ + + W E + +G Sbjct: 291 EKKLPIHHIPGPEG-VRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQIEKEKAKG 349 >4G5H-A nrPDB Length = 363 Score = 126 bits (317), Expect = 2e-29, Method: Composition-based stats. Identities = 56/304 (18%), Positives = 103/304 (33%), Gaps = 52/304 (17%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLC 71 KI+L+TGG G G+ + +++ + + D + + + FY D+ Sbjct: 26 KILLITGGTGSFGNAVMKRFLDSNIKEIRIFSRDEKKQDDIRK--KYNNSKLKFYIGDVR 83 Query: 72 DRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFV 131 D + +E ++ +D V H A LK V P+ NI+GT +L+ NV K + Sbjct: 84 DSQSVETAMRD--VDYVFHAAALKQVPSCEFFPVEAVKTNIIGTENVLQSAIHQNVKKVI 141 Query: 132 FSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENI-LNDLYNSDKKSWKFAIL 190 S+ P N G +K +E + + N + Sbjct: 142 CLSTD------------------KAAYPINAMGISKAMMEKVFVAKSRNIRSEQTLICGT 183 Query: 191 RYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYIH 250 RY N + + S ++P G+ D R + Sbjct: 184 RYGNVMASRGS-------------VIPLFIDKIKA--------GEPLTITDPDMTRFLMS 222 Query: 251 VVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYKVTGR 310 + D + + A ++ E + STV ++ A + D ++ G Sbjct: 223 LEDAVELVVHAFKHAETGDIMVQKAPS--------STVGDLATALLELFEADNAIEIIGT 274 Query: 311 RAGD 314 R G+ Sbjct: 275 RHGE 278 >4R1T-A nrPDB Length = 337 Score = 125 bits (313), Expect = 8e-29, Method: Composition-based stats. Identities = 70/328 (21%), Positives = 109/328 (33%), Gaps = 49/328 (14%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVL--TKHHIPFYE 67 + ++V VTG G+I S V L+E GY V + N L L K + + Sbjct: 9 SGQVVCVTGAGGFIASWLVKILLEKGYT--VRGTVRNPDDPKNGHLRELEGAKERLTLCK 66 Query: 68 VDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNV 127 DL D + L + D V H A T P + ++GT ++ + NV Sbjct: 67 ADLLDYQSLREAI--NGCDGVFHTA-----SPVTDDPEQMVEPAVIGTKNVINAAAEANV 119 Query: 128 SKFVFSSS-ATVYGDATRFPNMIPIPEECPLGPT------NPYGHTKYAIENILNDLYNS 180 + VF+SS VY D R P + + E C P N Y + K E + Sbjct: 120 RRVVFTSSIGAVYMDPNRDPETV-VDETCWSDPDFCKNTKNWYCYGKMVAEQ--AAWEEA 176 Query: 181 DKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSR 240 +K ++ +P+ + LL +V K Y+ G Sbjct: 177 KEKGVDLVVI----------------NPVLVQGPLLQTTVNASVLHILK-YLTGSAKTYA 219 Query: 241 DGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKAS- 299 + Y+ V D+A HI + EA + G +V K Sbjct: 220 NSVQA--YVDVKDVALAHILLYETPEASGRYLCAESVLHRG--------DVVEILSKFFP 269 Query: 300 GIDLPYKVTGRRAGDVLNLTAKPDRAKR 327 +P K + V + K Sbjct: 270 EYPIPTKCSDVTKPRVKPYKFSNQKLKD 297 >4WKG-A nrPDB Length = 660 Score = 116 bits (291), Expect = 3e-26, Method: Composition-based stats. Identities = 69/358 (19%), Positives = 129/358 (36%), Gaps = 43/358 (12%) Query: 13 IVLVTGGAGYIGSHTVVELI-ENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLC 71 VL+ G G+IG+H L+ E+ Y+ D D+++R L H F E D+ Sbjct: 317 RVLILGVNGFIGNHLTERLLREDHYEVYGLDI----GSDAISRF--LNHPHFHFVEGDIS 370 Query: 72 DRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFV 131 + + K D V+ + E T+ PLR + + + ++ +Y + + Sbjct: 371 IHSEWIE-YHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYCVKYR-KRII 428 Query: 132 FSSSATVYG--DATRFPNMIPIPEECPLG-PTNPYGHTKYAIENILNDLYNSDKKSWKFA 188 F S++ VYG F P+ P Y +K ++ ++ +K+ +F Sbjct: 429 FPSTSEVYGMCSDKYFDEDHSNLIVGPVNKPRWIYSVSKQLLDRVI--WAYGEKEGLQFT 486 Query: 189 ILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDY 248 + R FN +G L +G + + + G KL G R T IRD Sbjct: 487 LFRPFNWMGPRLDNLNAAR-IGSSRAITQLILNLVEGSPIKLIDGGKQ--KRCFTDIRDG 543 Query: 249 IHVVDLAKGHIAALQYLEAYNENEGLCREWNLGS-GKGSTVFEVYHAFCKASG-IDLPYK 306 I AL + N N+G+ +++ E+ + L + Sbjct: 544 IE----------ALYRIIENAGNRCDGEIINIGNPENEASIEELGEMLLASFEKHPLRHH 593 Query: 307 --------------VTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTE 350 G+ DV + A R L W+ ++ ++++ + + Sbjct: 594 FPPFAGFRVVESSSYYGKGYQDVEHRKPSIRNAHRCLDWEPKIDMQETIDETLDFFLR 651 >4J2O-A nrPDB Length = 363 Score = 115 bits (287), Expect = 9e-26, Method: Composition-based stats. Identities = 49/236 (20%), Positives = 84/236 (35%), Gaps = 31/236 (13%) Query: 7 SESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFY 66 S K++L+TGG G G+ + +E + + D + + + FY Sbjct: 19 SMFKDKVLLITGGTGSFGNAVLKRFLETDIKEIRIFSRDEKKQDDMRKKYH--SAKLKFY 76 Query: 67 EVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN 126 D+ D + + +D + H A LK V P+ N+LGT +LE Q + Sbjct: 77 IGDVRDYNSI--LNATRGVDYIYHAAALKQVPSCEFHPMEAVKTNVLGTENVLEAAIQNH 134 Query: 127 VSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIEN-ILNDLYNSDKKSW 185 V + V S+ + P N G +K +E ++ N + Sbjct: 135 VKRVVCLSTD------------------KAVYPINAMGISKAMMEKVMVAKSRNLEGLDT 176 Query: 186 KFAILRYFNPIGAHPS-------GLIGEDPLGIPN-NLLPYMAQVAVGRREKLYIF 233 RY N + + S + PL I + N+ +M + LY F Sbjct: 177 VICGTRYGNVMASRGSVIPLFVDQIRQGKPLTITDPNMTRFMMTLEDAVDLVLYAF 232 >4BKP-A nrPDB Length = 336 Score = 112 bits (279), Expect = 7e-25, Method: Composition-based stats. Identities = 72/357 (20%), Positives = 128/357 (35%), Gaps = 48/357 (13%) Query: 2 TAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKH 61 T L +S +LVTGG+G +G VVAD + + V +K Sbjct: 15 TENLYFQSM--RILVTGGSGLVGKAIQK---------VVAD---GAGLPGEDWVFVSSKD 60 Query: 62 HIPFYEVDLCDRKGLEKVFKEYKIDSVIHFAGL-KAVGESTQIPLRYYHNNILGTVVLLE 120 DL D +F++ + VIH A + + + + L ++ N+ +L Sbjct: 61 ------ADLTDTAQTRALFEKVQPTHVIHLAAMVGGLFRNIKYNLDFWRKNVHMNDNVLH 114 Query: 121 LMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNP---YGHTKYAIENILNDL 177 + K V S ++ D T +P + P P N Y + K I+ Sbjct: 115 SAFEVGARKVVSCLSTCIFPDKTTYPIDETMIHNGP--PHNSNFGYSYAKRMIDVQNRAY 172 Query: 178 YNSDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDY 237 + ++ I N G H + I + + L+ + +A L ++G Sbjct: 173 FQQYGCTFTAVI--PTNVFGPHDNFNI--EDGHVLPGLIHKVH-LAKSSGSALTVWGT-- 225 Query: 238 DSRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCK 297 G P R +I+ +DLA+ I L YNE E + ++G ++ E A + Sbjct: 226 ----GNPRRQFIYSLDLAQLFI---WVLREYNEVEPI--ILSVGEEDEVSIKEAAEAVVE 276 Query: 298 ASGIDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTEL---QVEDSCKDLWKWTTEN 351 A ++ TA + + L + + + K+ W T+N Sbjct: 277 AMDFHGEVTFDTTKSDGQFKKTASNSKLRTYL---PDFRFTPFKQAVKETCAWFTDN 330 >2GN9-A nrPDB Length = 344 Score = 107 bits (267), Expect = 2e-23, Method: Composition-based stats. Identities = 41/200 (20%), Positives = 77/200 (38%), Gaps = 24/200 (12%) Query: 4 QLQSESTSKIVLVTGGAGYIGSHTVVELIEN-GYDCVVADNLSNSTYDSVARLEVLTKHH 62 Q+ ++ +L+TGG G G V ++++ ++ + +A Sbjct: 14 NHQNMLDNQTILITGGTGSFGKCFVRKVLDTTNAKKIIVYSRDELKQSEMA--MEFNDPR 71 Query: 63 IPFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELM 122 + F+ D+ D + L + +D IH A LK V + PL NI+G ++ Sbjct: 72 MRFFIGDVRDLERLNYALE--GVDICIHAAALKHVPIAEYNPLECIKTNIMGASNVINAC 129 Query: 123 QQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDK 182 + +S+ + S+ P N YG TK + + N Sbjct: 130 LKNAISQVIALSTD------------------KAANPINLYGATKLCSDKLFVSANNFKG 171 Query: 183 KS-WKFAILRYFNPIGAHPS 201 S +F+++RY N +G+ S Sbjct: 172 SSQTQFSVVRYGNVVGSRGS 191 >4R1U-A nrPDB Length = 349 Score = 103 bits (256), Expect = 3e-22, Method: Composition-based stats. Identities = 64/325 (19%), Positives = 103/325 (31%), Gaps = 47/325 (14%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTK--HHIPFYEVD 69 + V VTG G+I S V L+E GY V + N L+ L + ++VD Sbjct: 28 QTVCVTGAGGFIASWLVKLLLERGYT--VRGTVRNPEDPKNGHLKELEGARERLTLHKVD 85 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSK 129 L D + ++ V + V H A T P + GT ++ + V + Sbjct: 86 LLDLQSIQSVV--HGCHGVFHTA-----SPVTDNPDEMLEPAVNGTKNVIIASAEAKVRR 138 Query: 130 FVFSSS-ATVYGDATRFPNMI-----PIPEECPLGPTNPYGHTKYAIENILNDLYNSDKK 183 VF+SS TVY D +++ E N Y + K E D+ + + Sbjct: 139 VVFTSSIGTVYMDPNTSRDVVVDESYWSDLEHCKNTKNWYCYGKTVAEQSAWDI--AKEN 196 Query: 184 SWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGT 243 ++ +G I + I Y+ G + T Sbjct: 197 QVDLVVVNPVVVLGPLLQPTINASTIHILK-----------------YLNGAAKTYVNAT 239 Query: 244 PIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKAS-GID 302 Y+HV D+A H+ E + + EV K Sbjct: 240 QS--YVHVKDVALAHLLVY-------ETNSASGRY-ICCETALHRGEVVEILAKYFPEYP 289 Query: 303 LPYKVTGRRAGDVLNLTAKPDRAKR 327 LP K + + V + K Sbjct: 290 LPTKCSDEKNPRVKPYKFSNQKLKD 314 >3WMX-A nrPDB Length = 358 Score = 101 bits (250), Expect = 1e-21, Method: Composition-based stats. Identities = 64/341 (18%), Positives = 117/341 (34%), Gaps = 36/341 (10%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYE 67 E+ +L+ G G IGS + L E N+ S R LT + Sbjct: 22 EAGKPKILIVGANGQIGSELALALAER----YGRTNVITSDVVPTGRHVHLTHEMLN--- 74 Query: 68 VDLCDRKGLEKVFKEYKIDSVIHF-AGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN 126 DR L V + + I V A L A GE + P ++ N+ + +LEL +Q Sbjct: 75 --ATDRGELATVVERHGITQVYLLAAALSATGE--KAPQWAWNLNMTSLLNVLELARQTG 130 Query: 127 VSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWK 186 + + + SS +G T P++ + PT YG +K A E + Sbjct: 131 LERVFWPSSIAAFGPTTPAGQT---PQKTVMEPTTVYGISKQAGEGWCR--WYHANHGVD 185 Query: 187 FAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIR 246 +RY I G + G ++ D+ Sbjct: 186 VRSVRYPGLISHKTPPGGGTTDYAVD-----IFHAAVTGEPYTCFLKEDEAL-------- 232 Query: 247 DYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKAS-GIDLPY 305 +++ D + I + +EA + +N+ G T ++ A + G + Y Sbjct: 233 PMMYMPDAIRATI---ELMEAPADKLSERGSYNIA-GMSFTPAQIAAAIREQVPGFQIRY 288 Query: 306 KVTGRRA-GDVLNLTAKPDRAKRELKWQTELQVEDSCKDLW 345 + R+A + A+ + W+ + +++ D+ Sbjct: 289 EPDYRQAIAQGWPDSIDDSVARADWGWKAQYGLKEMVADML 329 >6AQY-A nrPDB Length = 341 Score = 98.0 bits (242), Expect = 1e-20, Method: Composition-based stats. Identities = 63/352 (17%), Positives = 117/352 (33%), Gaps = 55/352 (15%) Query: 13 IVLVTGGAGYIGS---HTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 ++LVTGG G G H V + G V + D Sbjct: 26 VILVTGGTGLFGKAVEHIVKKEQIKG-KWVFLGSKD----------------------GD 62 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAG-LKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVS 128 L D ++ F++Y+ VIH A + + ++ + ++ +N+ +L + V Sbjct: 63 LRDADACKQPFEKYRPTYVIHLAAFVGGLFKNMNFKVSFWLDNVNMNNNILTCCYDFGVK 122 Query: 129 KFVFSSSATVYGDATRFPNMIPIPEECPLGPT-NPYGHTKYAIENILNDLYNSDKKSWKF 187 K + S V+ D +P E P + N Y + K ++ +L YN + Sbjct: 123 KTISCLSTCVFPDKIEYPITEEKLHEGPPHFSNNAYAYAKRMLD-MLGRWYNEKAVNEGK 181 Query: 188 AILRYFNPIGAHPSGLIGEDPLGIPN--NLLPYMAQ---VAVGRREKLYIFGDDYDSRDG 242 + L P+ L G ++LP + A +FG G Sbjct: 182 SCLF----TSVIPTNLFGPHDNFNVEAGHVLPGLMHKCYKAQQNGTDFVVFGS------G 231 Query: 243 TPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGID 302 P+R +++ D A+ L + Y E + + ++ +V A Sbjct: 232 KPLRQFLYSHDAAR---MLLWTMFNYQSEEPIMLC--VSEEDEKSIGQVAQTIKDAFNFT 286 Query: 303 LPYKVTGRRAGDVLNLTAKPDRAKR---ELKWQTELQVEDSCKDLWKWTTEN 351 +A T+ + R ++ E + K+ +W EN Sbjct: 287 GNMVFDTSKADGQYKKTSSNAKFLRLNPTFQYTP---FEQAIKETVQWFLEN 335 >2NNL-D nrPDB Length = 337 Score = 94.1 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 66/345 (19%), Positives = 126/345 (36%), Gaps = 37/345 (10%) Query: 9 STSKIVLVTGGAGYIGSHTVVELIENGYDC--VVADNLSNSTYDSVARLEVLTKHHIPFY 66 S S+ V VTG +G+IGS V+ L+E GY V D + + L + H+ + Sbjct: 3 SQSETVCVTGASGFIGSWLVMRLLERGYTVRATVRDPTNVKKVKHLLDLPK-AETHLTLW 61 Query: 67 EVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPL-RYYHNNILGTVVLLELMQQY 125 + DL D ++ K V H A + ++ P I G + +++ Sbjct: 62 KADLADEGSFDEAIK--GCTGVFHVATP--MDFESKDPENEVIKPTIEGMLGIMKSCAAA 117 Query: 126 N-VSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKS 184 V + VF+SSA G + +P+ +E K +++ + Sbjct: 118 KTVRRLVFTSSA---GTVNIQEHQLPVYDESCWSDMEFCRAKKMTAWMYFVSKTLAEQAA 174 Query: 185 WKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTP 244 WK+A + I P+ ++G I +++ P + I G++ + Sbjct: 175 WKYAKENNIDFITIIPTLVVGP---FIMSSMPPSLITALS------PITGNEAHY---SI 222 Query: 245 IR--DYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFC-KASGI 301 IR ++H+ DL HI EN + + S + ++ K Sbjct: 223 IRQGQFVHLDDLCNAHIYLF-------ENPKAEGRY-ICSSHDCIILDLAKMLREKYPEY 274 Query: 302 DLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWK 346 ++P + G + L + +L ++ + +ED Sbjct: 275 NIPTEFKGV--DENLKSVCFSSKKLTDLGFEFKYSLEDMFTGAVD 317 >5B6K-A nrPDB Length = 366 Score = 92.2 bits (227), Expect = 7e-19, Method: Composition-based stats. Identities = 68/356 (19%), Positives = 121/356 (33%), Gaps = 38/356 (10%) Query: 9 STSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEV 68 S V V+G G+I H V +L++ Y V ++ ++ + + + V Sbjct: 19 SHMTTVFVSGATGFIAQHVVRQLLDQNYK--VIGSVRSAEKGDHLKNVIFKGGDFNYEIV 76 Query: 69 -DLCDRKGLEKVFKEYKIDS--VIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQY 125 D+ D + VF+++ D V+H A +T I + GT +LE +++Y Sbjct: 77 KDISDPTAFDHVFEKHGKDIKVVLHTASPFHF-NTTDIEKDLLIPAVNGTKGILESIKKY 135 Query: 126 ---NVSKFVFSSS--------ATVYGD-----ATRFPNMIPIPEECPLGPTNPYGHTKYA 169 V + V +SS Y T E C P Y +K Sbjct: 136 AAQTVERVVVTSSFAANTSTVDMFYAKDSSKTITEESWNQDTWESCQSDPIRGYCGSKKF 195 Query: 170 IENILNDLYNSDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREK 229 E D YN++K S KF + P + + + + V + + + Sbjct: 196 AEKAAWDFYNANKDSVKFKLSIINPVYVFGPQNYVEPGKKILNTSSEVINSLVHLKKDDP 255 Query: 230 LYIFGDDYDSRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVF 289 L F + I V D+AK HI A Q E + + G T+ Sbjct: 256 LPEFAGGH-----------IDVRDVAKAHILAFQKDELIEQRL----MLHAGLFTTQTLL 300 Query: 290 EVYHAFCKASGIDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLW 345 ++ + +P G D + K+ L ++ + ++ D Sbjct: 301 DIINEQFPELKGKIPAGKPGTGNPDDALTPVDNSKTKKLLGFE-FIDLKKDLYDTI 355 >4KTT-E nrPDB Length = 327 Score = 91.4 bits (225), Expect = 1e-18, Method: Composition-based stats. Identities = 54/342 (15%), Positives = 94/342 (27%), Gaps = 54/342 (15%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 ++ VLVTG G +G E +N + V F +V+L Sbjct: 21 NRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGFRRA---------------RPKFEQVNL 65 Query: 71 CDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKF 130 D + + +++ ++H A + P N+ + L + Sbjct: 66 LDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNLAKEAAAVGAF-L 124 Query: 131 VFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAIL 190 ++ SS V+ P EE P N YG TK E + + + A+L Sbjct: 125 IYISSDYVFDGTNP-----PYREEDIPAPLNLYGKTKLDGEKAVLE------NNLGAAVL 173 Query: 191 RYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYIH 250 R G + F + + D R H Sbjct: 174 RIPILYGEVEKLEESAVTVMFDK-----------------VQFSNKSANMDHWQQRFPTH 216 Query: 251 VVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDL----PYK 306 V D+A Q E + + ++ + T +E+ A A + P Sbjct: 217 VKDVAT---VCRQLAEKRMLDPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPIT 273 Query: 307 VTGRRAG-DVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKW 347 + N + L K+ W Sbjct: 274 DSPVLGAQRPRNAQLDCSKL-ETLGIGQRTPFRIGIKESL-W 313 >3OS7-A nrPDB Length = 341 Score = 89.5 bits (220), Expect = 5e-18, Method: Composition-based stats. Identities = 60/322 (18%), Positives = 109/322 (33%), Gaps = 32/322 (9%) Query: 383 RFQATFAN-LGASIVDL--KVNGQSVVLGYEN---EEGYLNPDSAYIGATIGRYANRISK 436 ++A +G ++V+L G +++ + E + N Y G + NRI Sbjct: 27 GYEALIIPDVGGNVVELKDTNKGVTILRTPKKDLKFEDFKNRPQVY-GLPVLFPPNRIDD 85 Query: 437 GKFSLCNKDYQLTVNNGVNANHSSIGSFHRKRFLGPIIQNPSKDVFTAEYMLI-DNEKDT 495 G F L +K Y+ +N N N+ + K + + K + + +NE Sbjct: 86 GTFKLGDKTYKFPINEAKNNNYIHGFIKNSKWTVHKKKIDQDKALVEVVFDFTKENEAYK 145 Query: 496 EFPGDLLVTIQYTVNVAQKSLEMVYKGKLTAGEATPINLTNHSYFNLNKPYGDTIEGTEI 555 F + + Y ++ K L+ + E P+++ HS FN+ G + Sbjct: 146 YFSHEFQFKLSYELSS--KGLKQTTSVVNLSSEEMPLSVGYHSAFNVPFIEGSEDSNCRV 203 Query: 556 MVRSKKSVDVDKNMIPTGNIVDREIATFNSTKPTVLGPKNPQFDCCFVVDENAKPSQINT 615 + K D +PTG +F T +N ++ I+ Sbjct: 204 KISIDKFWKQDSRNLPTGE-------SFAPTGEQKEYLENGVAVASHPIESLFSLKDIDV 256 Query: 616 LNNELT-LIVKAFHPDSNITLEVLSTEPTYQFYTGDFLSAGYEARQGFAIEPGRYIDAIN 674 ++ ++ + E+ S + D Y IEP I IN Sbjct: 257 NGKTFRGACIEDASKNTRVVYEMSSEYKYLVIWN-DMGDKKYA-----CIEPQTSI--IN 308 Query: 675 QENWK------DCVTLKNGETY 690 N K TLK E++ Sbjct: 309 SPNVKLDRSVSGFKTLKPNESW 330 >2P4H-X nrPDB Length = 322 Score = 87.2 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 56/347 (16%), Positives = 103/347 (29%), Gaps = 44/347 (12%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDC---VVADNLSNSTYDSVARLEVLTKHHIPFYE 67 V VTGG G++GS + L+ENGY + AD + L + F+ Sbjct: 1 KGRVCVTGGTGFLGSWIIKSLLENGYSVNTTIRADPERKRDVSFLTNLP-GASEKLHFFN 59 Query: 68 VDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN- 126 DL + + + H A S + + G + +L+ Sbjct: 60 ADLSNPDSFAAAIE--GCVGIFHTASPIDFAVSEPEEIVTKRT-VDGALGILKACVNSKT 116 Query: 127 VSKFVFSSSATVY---GDATRFPNMIPIPEECPLGPTNP----YGHTKYAIENILNDLYN 179 V +F+++SS + G + + L P Y +K E + + Sbjct: 117 VKRFIYTSSGSAVSFNGKDKDVLDESDWSDVDLLRSVKPFGWNYAVSKTLAEKAVLEF-- 174 Query: 180 SDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDS 239 ++ L +P + ++ EK + Sbjct: 175 GEQNGIDVVTL-------------------ILPFIVGRFVCPKLPDSIEKALVLVLGKKE 215 Query: 240 RDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKAS 299 + G +HV D+A+ HI L EN +N S + E+ Sbjct: 216 QIGVTRFHMVHVDDVARAHIYLL-------ENSVPGGRYN-CSPFIVPIEEMSQLLSAKY 267 Query: 300 GIDLPYKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWK 346 V + L + + + + +ED D + Sbjct: 268 PEYQILTVDELKEIKGARLPDLNTKKLVDAGFDFKYTIEDMFDDAIQ 314 >4QUK-A nrPDB Length = 319 Score = 84.9 bits (208), Expect = 1e-16, Method: Composition-based stats. Identities = 65/343 (18%), Positives = 129/343 (37%), Gaps = 42/343 (12%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDC--VVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 +V VTG +GYI S V L+ GY V D D + +L K + ++ + Sbjct: 1 NVVCVTGASGYIASWLVRLLLHRGYTVKATVRDPNDPKKVDHLVKL-DGAKERLQLFKAN 59 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIP-LRYYHNNILGTVVLLE-LMQQYNV 127 L + + V + V H A + P + GT+ +L + ++ Sbjct: 60 LLEEGAFDSVVQ--GCHGVFHTASPFYHD--VKDPQAELIDPALKGTLNVLNSCAKSPSL 115 Query: 128 SKFVFSSS--ATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSW 185 + V +SS A Y R P+++ + E T+ K + +++ +++ +W Sbjct: 116 KRVVLTSSIAAVAYNGKPRTPDVV-VDET---WFTDADFCAKSNLWYVVSATL-AEEAAW 170 Query: 186 KFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRRE-KLYIFGDDYDSRDGTP 244 KF + + +P+ +IG + N + + G + FG Sbjct: 171 KFVKENNIDMVTINPAMVIGPLLQPVLNTSAAAILNLINGAQTFPNASFG---------- 220 Query: 245 IRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASG-IDL 303 +++V D+A HI A + A + + R + EV + + L Sbjct: 221 ---WVNVKDVANAHILAYENASASGRHCLVERVAHYS--------EVVRILRELYPSLQL 269 Query: 304 PYKVTGRRAGDVLNLTAKPDRAKRE-LKWQT-ELQVEDSCKDL 344 P K + V ++AK L++ E+ ++++ + L Sbjct: 270 PEKCADDKPY-VPIYQVSKEKAKSLGLEYTPLEVSIKETVESL 311 >3RFT-A nrPDB Length = 267 Score = 81.0 bits (198), Expect = 2e-15, Method: Composition-based stats. Identities = 38/210 (18%), Positives = 69/210 (32%), Gaps = 24/210 (11%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 K +LVTG AG +G L + + +LS + + DL Sbjct: 3 MKRLLVTGAAGQLGRVMRERLAPMA-EILRLADLS---------PLDPAGPNEECVQCDL 52 Query: 71 CDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHN-NILGTVVLLELMQQYNVSK 129 D + + D ++H G S + P NI+G L E + + + Sbjct: 53 ADANAVNAMVA--GCDGIVHLG-----GISVEKPFEQILQGNIIGLYNLYEAARAHGQPR 105 Query: 130 FVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAI 189 VF+SS G +P + + P P YG +K EN+ ++ + Sbjct: 106 IVFASSNHTIG---YYPQTERLGPDVPARPDGLYGVSKCFGENLARMYFDKFGQETALVR 162 Query: 190 LRYFNPIGAHPSGLIGEDPLGIPNNLLPYM 219 + P+ ++ + + Sbjct: 163 I---GSCTPEPNNYRMLSTWFSHDDFVSLI 189 >3HFS-A nrPDB Length = 338 Score = 81.0 bits (198), Expect = 2e-15, Method: Composition-based stats. Identities = 58/358 (16%), Positives = 114/358 (31%), Gaps = 52/358 (14%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTK----HHIPFY 66 K V GG G++ S V L++ GY N + D+ ++ L + + + Sbjct: 9 KKTACVVGGTGFVASLLVKLLLQKGYAV----NTTVRDPDNQKKVSHLLELQELGDLKIF 64 Query: 67 EVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPL-RYYHNNILGTVVLLELM-QQ 124 DL D E D V H A + P I G V +++ + Sbjct: 65 RADLTDELSFEAPIA--GCDFVFHVATPVHFAS--EDPENDMIKPAIQGVVNVMKACTRA 120 Query: 125 YNVSKFVFSSSATVYGDATRFPNMIPIPE---------ECPLGPTNPYGHTKYAIENILN 175 +V + + +SSA + + E PT Y +K E Sbjct: 121 KSVKRVILTSSAAAVTINQLDGTGLVVDEKNWTDIEFLTSAKPPTWGYPASKTLAEK--A 178 Query: 176 DLYNSDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGD 235 +++ + + G+ + + +G+ +L+ + G + + G Sbjct: 179 AWKFAEENNIDLITVIPTLMAGSSLTSDV-PSSIGLAMSLITGNEFLINGMKGMQMLSGS 237 Query: 236 DYDSRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAF 295 + HV D+ + HI E E + + ++V E+ Sbjct: 238 VSIA----------HVEDVCRAHIFV-------AEKESASGRY-ICCAANTSVPELAKFL 279 Query: 296 CKASGIDLPYKVTGRRAGDVL---NLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTE 350 K YKV GD L ++ +E + + +E+ + ++ Sbjct: 280 SKRYP---QYKV-PTDFGDFPPKSKLIISSEKLVKE-GFSFKYGIEEIYDESVEYFKA 332 >5U9C-A nrPDB Length = 292 Score = 80.2 bits (196), Expect = 3e-15, Method: Composition-based stats. Identities = 41/219 (18%), Positives = 75/219 (34%), Gaps = 40/219 (18%) Query: 7 SESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFY 66 S + + +L+TGG G +G++ L + Y+ +V T + L V Sbjct: 1 SNAMKRKILITGGTGMLGAYVTSALKDTDYNVIV-------TERNTLNLSVP-------- 45 Query: 67 EVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN 126 + + K D ++HFA V + P R N L T + + + Sbjct: 46 -------EAIFSYITAEKPDVILHFAAETDVDLCEREPARAGIYNHLATEQIAQAAKFCG 98 Query: 127 VSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWK 186 ++ SS+ V+G + E P N YG +K E+ + + + Sbjct: 99 AW-LLYLSSSNVFGGEGKL----SYNELDIPLPMNYYGRSKLIGESSVRNACTN------ 147 Query: 187 FAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVG 225 N + +IG P + + Q+ G Sbjct: 148 -------NHLIIRAGWMIGGGPDKDHKFVGKIIQQIKAG 179 >1VL0-A nrPDB Length = 292 Score = 79.5 bits (194), Expect = 4e-15, Method: Composition-based stats. Identities = 35/181 (19%), Positives = 60/181 (33%), Gaps = 27/181 (14%) Query: 2 TAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKH 61 + ++ +L+TG G +G +L + + D Sbjct: 3 SDKIHHHHHHMKILITGANGQLGREIQKQLKGKNVEVIPTD------------------- 43 Query: 62 HIPFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLEL 121 ++D+ + + K F E K + VI+ A AV + + Y N +G L Sbjct: 44 ---VQDLDITNVLAVNKFFNEKKPNVVINCAAHTAVDKCEEQYDLAYKINAIGPKNLAAA 100 Query: 122 MQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSD 181 V S+ V+ + PI E + P + YG TK EN + L Sbjct: 101 AYSVGAE-IVQISTDYVFDGEAK----EPITEFDEVNPQSAYGKTKLEGENFVKALNPKY 155 Query: 182 K 182 Sbjct: 156 Y 156 >4PVC-A nrPDB Length = 342 Score = 77.5 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 65/356 (18%), Positives = 124/356 (34%), Gaps = 48/356 (13%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPF---YEV 68 V V+G G+I H V L++ Y + S + + L ++ F Sbjct: 1 MSVFVSGANGFIAQHIVDLLLKEDYKVIG----SARSQEKAENLTEAFGNNPKFSMEVVP 56 Query: 69 DLCDRKGLEKVFKEYKID--SVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQY- 125 D+ + VF+++ D V+H A + T + G +L +++Y Sbjct: 57 DISKLDAFDHVFQKHGKDIKIVLHTA-SPFCFDITDSERDLLIPAVNGVKGILHSIKKYA 115 Query: 126 --NVSKFVFSSS-ATVYGDATRFPNMIPIPEE---------CPLGPTNPYGHTKYAIENI 173 +V + V +SS A V+ A + EE C P N Y +K E Sbjct: 116 ADSVERVVLTSSYAAVFDMAKENDKSLTFNEESWNPATWESCQSDPVNAYCGSKKFAEKA 175 Query: 174 LNDLYNSDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLY-I 232 + ++ S KF + P + + + + + + +K+ + Sbjct: 176 AWEFLEENRDSVKFELTAVNPVYVFGPQMFDKDVKKHLNTSCELVNSLMHLSPEDKIPEL 235 Query: 233 FGDDYDSRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVY 292 FG YI V D+AK H+ A Q E + + T+ +V Sbjct: 236 FGG------------YIDVRDVAKAHLVAFQKRETIGQRLIVSEA-------RFTMQDVL 276 Query: 293 HAFCK---ASGIDLPYKVTGRRA-GDVLNLTAKPDRAKRELKWQTELQVEDSCKDL 344 + ++P G A + L T ++K+ L ++ ++++ D Sbjct: 277 DILNEDFPVLKGNIPVGKPGSGATHNTLGATLDNKKSKKLLGFKFR-NLKETIDDT 331 >3SC6-A nrPDB Length = 287 Score = 77.2 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 43/199 (21%), Positives = 76/199 (38%), Gaps = 35/199 (17%) Query: 7 SESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFY 66 S + + V++TG G +G EL YD D Sbjct: 1 SNAMKERVIITGANGQLGKQLQEELNPEEYDIYPFDKKL--------------------- 39 Query: 67 EVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN 126 +D+ + +++V +E + +IH A V ++ + Y N +G + + Q Sbjct: 40 -LDITNISQVQQVVQEIRPHIIIHCAAYTKVDQAEKERDLAYVINAIGARNV-AVASQLV 97 Query: 127 VSKFVFSSSATVY-GDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSW 185 +K V+ S+ V+ GD E P N YG +KYA E + +L+N Sbjct: 98 GAKLVYISTDYVFQGDRPE-----GYDEFHNPAPINIYGASKYAGEQFVKELHN------ 146 Query: 186 KFAILRYFNPIGAHPSGLI 204 K+ I+R G + + + Sbjct: 147 KYFIVRTSWLYGKYGNNFV 165 >4WPG-A nrPDB Length = 289 Score = 74.5 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 36/171 (21%), Positives = 57/171 (33%), Gaps = 26/171 (15%) Query: 13 IVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCD 72 ++L+TG G +G+ L E G D V D E+D+ + Sbjct: 6 MILITGSNGQLGTELRYLLDERGVDYVAVD----------------------VAEMDITN 43 Query: 73 RKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYH-NNILGTVVLLELMQQYNVSKFV 131 +E VF + K V H A AV + N+ G+ + + +Y + V Sbjct: 44 EDKVEAVFAQVKPTLVYHCAAYTAVDAAEDEGKALNEAINVTGSENIAKACGKYGAT-LV 102 Query: 132 FSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDK 182 + S+ V+ P E P YG TK E + Sbjct: 103 YISTDYVFDGNK--PVGQEWVETDHPDPKTEYGRTKRLGELAVERYAEHFY 151 >2GGS-A nrPDB Length = 273 Score = 72.5 bits (176), Expect = 6e-13, Method: Composition-based stats. Identities = 33/185 (17%), Positives = 59/185 (31%), Gaps = 22/185 (11%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLC 71 L+TG +G +G L E ++ + N S Y++DL Sbjct: 1 MRTLITGASGQLGIELSRLLSER-HEVIKVYNSSEIQGG---------------YKLDLT 44 Query: 72 DRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFV 131 D LE + + D +I+ A + V + + Y N ++ + + V Sbjct: 45 DFPRLEDFIIKKRPDVIINAAAMTDVDKCEIEKEKAYKINAEAVRHIVRAGKVIDSY-IV 103 Query: 132 FSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAILR 191 S+ V+ EE P N YG +K E + ++ + Sbjct: 104 HISTDYVFDG-----EKGNYKEEDIPNPINYYGLSKLLGETFALQDDSLIIRTSGIFRNK 158 Query: 192 YFNPI 196 F Sbjct: 159 GFPIY 163 >3PVZ-A nrPDB Length = 399 Score = 66.4 bits (160), Expect = 5e-11, Method: Composition-based stats. Identities = 49/254 (19%), Positives = 85/254 (33%), Gaps = 47/254 (18%) Query: 3 AQLQSESTSKIVLVTGGAGYIGSHTVVELIENG-YDCVVADNLSNSTYDSVARLEVLTKH 61 +LQS + LV GGAG IG E+ + V D + +++ L + Sbjct: 27 KELQSVVSQSRFLVLGGAGSIGQAVTKEIFKRNPQKLHVVDI----SENNMVELVRDIRS 82 Query: 62 HIPFYEVDL----CDRKGLEK---VFKEYKIDSVIHFAGLKAVGESTQIP---LRYYHNN 111 + D D +E + + + D V++ + LK V S + P +R N Sbjct: 83 SFGYINGDFQTFALDIGSIEYDAFIKADGQYDYVLNLSALKHV-RSEKDPFTLMRMIDVN 141 Query: 112 ILGTVVLLELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIE 171 + T ++ K+ S+ P N G +K +E Sbjct: 142 VFNTDKTIQQSIDAGAKKYFCVSTD------------------KAANPVNMMGASKRIME 183 Query: 172 NILNDLYNSDKKSWKFAILRYFNPIGAHPSGLIGED-------PLGIPNNLLPYMAQVAV 224 L + + R+ N + S L G + P+ PN++ Y Sbjct: 184 MFLMR----KSEEIAISTARFANVAFSDGSLLHGFNQRIQKNQPIVAPNDIKRYFVTPQE 239 Query: 225 GRREKLY--IFGDD 236 L IFG++ Sbjct: 240 SGELCLMSCIFGEN 253 >1KC3-A nrPDB Length = 299 Score = 65.6 bits (158), Expect = 7e-11, Method: Composition-based stats. Identities = 65/346 (18%), Positives = 101/346 (29%), Gaps = 66/346 (19%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLC 71 +L+ G G +G L V L L H F D Sbjct: 1 MNILLFGKTGQVGWELQRSL------------------APVGNLIALDVHSKEFC-GDFS 41 Query: 72 DRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFV 131 + KG+ + ++ + D +++ A AV ++ P N + + + V Sbjct: 42 NPKGVAETVRKLRPDVIVNAAAHTAVDKAESEPELAQLLNATSVEAIAKAANETGAW-VV 100 Query: 132 FSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAILR 191 S+ V+ IP E P N YG TK A E L D K I R Sbjct: 101 HYSTDYVFPGTGD----IPWQETDATSPLNVYGKTKLAGEKALQDNCP------KHLIFR 150 Query: 192 YFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYIHV 251 NN M ++A R+ L + D Y + G Sbjct: 151 TSWVYAGKG------------NNFAKTMLRLAK-ERQTLSVINDQYGAPTG--------A 189 Query: 252 VDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDL-------- 303 LA A++ E GL G+ + + +GI L Sbjct: 190 ELLADCTAHAIRVALNKPEVAGLYHLVAGGTTTWHDYAALVFDEARKAGITLALTELNAV 249 Query: 304 PYKVTGRRAGDVLNLTAKPDRAKRELK-----WQTELQVEDSCKDL 344 P A N ++ +R W EL V+ ++ Sbjct: 250 PTSAYPTPASRPGNSRLNTEKFQRNFDLILPQW--ELGVKRMLTEM 293 >1ZZE-A nrPDB Length = 342 Score = 64.8 bits (156), Expect = 1e-10, Method: Composition-based stats. Identities = 45/197 (22%), Positives = 69/197 (35%), Gaps = 29/197 (14%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 +VLVTG G++ SH V +L+E+GY T S ++L L K Y Sbjct: 10 EGSLVLVTGANGFVASHVVEQLLEHGYKV-------RGTARSASKLANLQKRWDAKYPGR 62 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNIL----GTVV-LLELMQQ 124 + +E + K+ D VI A A S Y + GT+ L Sbjct: 63 F-ETAVVEDMLKQGAYDEVIKGAAGVAHIASVVSFSNKYDEVVTPAIGGTLNALRAAAAT 121 Query: 125 YNVSKFVFSSSA-----------TVYGDATRF-----PNMIPIPEECPLGPTNPYGHTKY 168 +V +FV +SS +Y D + +PE P Y +K Sbjct: 122 PSVKRFVLTSSTVSALIPKPNVEGIYLDEKSWNLESIDKAKTLPESDPQKSLWVYAASKT 181 Query: 169 AIENILNDLYNSDKKSW 185 E + +K + Sbjct: 182 EAELAAWKFMDENKPHF 198 >5YWN-A nrPDB Length = 334 Score = 61.8 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 63/354 (17%), Positives = 124/354 (35%), Gaps = 44/354 (12%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 + V V+G GY+ + ++ GY V S + + A L+ L + V Sbjct: 1 MTTSVFVSGATGYLAQQIIALVLSKGYKVVG----SVRSEEKGANLKKLYGDDFSYEVVK 56 Query: 70 LCD-RKGLEKVFKEYKIDSVI-HFAGLKAVGESTQIPLRYYH-NNILGTVVLLELMQQY- 125 + + + ++ K++ ++ H A V + + I GT +L+ ++ Sbjct: 57 VLEQKGAFDEALKKHPEVTIFLHTA--SPVTFEVEDTEKEILIPAINGTKYVLQSIKDVA 114 Query: 126 -NVSKFVFSSS--ATVYGDATRFPNMIPIP--------EECPLGPTNPYGHTKYAIENIL 174 +++ V++SS A + P+++ E+ Y +K E Sbjct: 115 PQITRVVYTSSVVAMSVPEELGSPDVVLSEASWSSLSYEQSKTHGVLAYFGSKQFAERAA 174 Query: 175 NDLYNSDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFG 234 + +K ++ + + G + L ++ + ++ Sbjct: 175 WEFVEQEKPNFALSTVNPVYIFGPQAKDEEVKGTLNHSAEMVNSVLKLNKD--------- 225 Query: 235 DDYDSRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCRE-WNLGSGKGSTVFEVYH 293 DD + GT +I V D+AK H+AA + EA E L +N G T+ +V Sbjct: 226 DDVPATTGT----FIDVRDVAKAHLAAFEKDEAKGERLLLSNTRFN-----GQTLLDVVR 276 Query: 294 AFCKASGIDLPYKVTGRRAGDVLNLTA-KPDRAKRELKWQTELQVEDSCKDLWK 346 LP V + D + K+ L ++ E S D K Sbjct: 277 KNFPQLADKLP--VGKPHSDDFSAFKEWNDKKTKKILGFE-YFDFETSVVDSIK 327 >3U5T-A nrPDB Length = 267 Score = 60.6 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 29/151 (19%), Positives = 59/151 (39%), Gaps = 14/151 (9%) Query: 2 TAQLQSEST---SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVL 58 T L +S +K+ +VTG + IG+ L +G+ V+ + + VA Sbjct: 15 TENLYFQSMMETNKVAIVTGASRGIGAAIAARLASDGFTVVINYAGKAAAAEEVAGKIEA 74 Query: 59 TKHHIPFYEVDLCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGESTQIPLRYYH---- 109 + D+ D + ++F +D +++ AG+ + + + Sbjct: 75 AGGKALTAQADVSDPAAVRRLFATAEEAFGGVDVLVNNAGIMPLTTIAETGDAVFDRVIA 134 Query: 110 NNILGTVV-LLELMQQYNV-SKFVFSSSATV 138 N+ GT L E Q+ V + + S++ V Sbjct: 135 VNLKGTFNTLREAAQRLRVGGRIINMSTSQV 165 >6GCS-E nrPDB Length = 375 Score = 60.6 bits (145), Expect = 3e-09, Method: Composition-based stats. Identities = 48/335 (14%), Positives = 114/335 (34%), Gaps = 72/335 (21%) Query: 7 SESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTK-HHIPF 65 S T V G G++GS+ +L ++G VV + L+V + F Sbjct: 49 SSRTGYTATVFGANGFLGSYLTAKLAKHGTTVVVPYR----EEMAKRHLKVTGDLGVVNF 104 Query: 66 YEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQY 125 E+DL + + +++ + D V++ G + ++ YY ++ G + E ++++ Sbjct: 105 LEMDLRNLESIDEAVR--HSDIVVNLIGREYETKNFN----YYDVHVEGARRIAEAVKKH 158 Query: 126 NVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSW 185 N+++++ S + P + + HTK E + D+ W Sbjct: 159 NIARYIHVS-------------AFNAEIDSP----SEFNHTKGLGEQVTKDIVP-----W 196 Query: 186 KFAILRYFNPIGAHPSGLIG-EDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTP 244 + P+ + G ED + + R L ++ + Sbjct: 197 ATIV---------RPAPMFGREDKWFLDR----------MARSPCLVSANKFQETSNP-- 235 Query: 245 IRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLP 304 +HV+D+A ++ + + + L + T ++ + ++ Sbjct: 236 ----VHVIDVAAALERI------CFDDSTVAQTFELYGPQKFTQKQIIDMVSETLRKEVR 285 Query: 305 YKVTGRRAGDVLNLTAKPDRAKRELKWQTELQVED 339 + + L +A + + W + Sbjct: 286 HIELPK------ALYQAYTKATQAI-WWPTYSPDQ 313 >3SLK-A nrPDB Length = 795 Score = 60.2 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 40/143 (27%), Positives = 61/143 (42%), Gaps = 13/143 (9%) Query: 11 SKIVLVTGGAGYIGSHTVVEL-IENGYDCVVADNLSNSTYDSVARLE---VLTKHHIPFY 66 + VLVTGG G +G+ L IE G +V + A L + Sbjct: 530 AGTVLVTGGTGALGAEVARHLVIERGVRNLVLVSRRGPAASGAAELVAQLTAYGAEVSLQ 589 Query: 67 EVDLCDRKGLEKVF----KEYKIDSVIHFAGLK--AVGES--TQIPLRYYHNNILGTVVL 118 D+ DR+ L KV E+ + +V+H AG+ V ES + + + G L Sbjct: 590 ACDVADRETLAKVLASIPDEHPLTAVVHAAGVLDDGVSESLTVERLDQVLRPKVDGARNL 649 Query: 119 LELMQQYNVSKFVFSSSATVYGD 141 LEL+ +V+ +FSS + V G Sbjct: 650 LELI-DPDVALVLFSSVSGVLGS 671 >4QQR-A nrPDB Length = 301 Score = 59.1 bits (141), Expect = 6e-09, Method: Composition-based stats. Identities = 24/134 (17%), Positives = 49/134 (36%), Gaps = 7/134 (5%) Query: 52 VARLEVLTKHHIPFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKA---VGESTQIPLRYY 108 + +L + L DR+ + + K V + AG+ V + Sbjct: 28 LGKLCEAQGITYTYGSGRLQDRQSIVADIESVKPSHVFNAAGVTGRPNVDWCESHKVETI 87 Query: 109 HNNILGTVVLLELMQQYNVSKFVFSSSATV--YGDATRFPNMIPIPEECPLGPT-NPYGH 165 N+ GT+ L ++ ++ + ++ + + Y + I EE T + Y Sbjct: 88 RTNVAGTLTLADICREKGLVLINYA-TGCIFEYDSGHPLGSGIGFKEEDTPNFTGSFYSK 146 Query: 166 TKYAIENILNDLYN 179 TK +E +L + N Sbjct: 147 TKAMVEELLKNYEN 160 >3NRE-A nrPDB Length = 291 Score = 54.0 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 44/274 (16%), Positives = 84/274 (30%), Gaps = 46/274 (16%) Query: 426 TIGRYANRISKGKFSLCNKDYQLTVNNG--VNANHSSIGSFHRKRFLGPIIQNPSKDVFT 483 + +ANR+S +F ++YQL N + H +LG D Sbjct: 50 PLVPFANRVSGNRFVWQGREYQLQPNVEWDAHYLHGDG-------WLGEWQCVSHSD--- 99 Query: 484 AEYMLIDNEKDTEFPGDLLVTIQYTVNVAQKSLEMVYKGKLTAGEATPINLTNHSYFNLN 543 L+ + + + T + +L + +G E P H YF L+ Sbjct: 100 DSLCLVYEHRSGVYHYRVSQAFHLTADTLTVTLSVTNQG----AETLPFGTGWHPYFPLS 155 Query: 544 KPYGDTIEGTEIMVRSKKSVDVDKNMIPTGNIVDREIATFNSTKPTVLGPKNPQFDCCFV 603 + + + ++ + G ++ + +P L Sbjct: 156 PQTRIQAQASGYWLEREQWL--------AGEFCEQLPQELDFNQPAPL------------ 195 Query: 604 VDENAKPSQINTLNNELTLIVKAFHPDSNITLEVLSTEPT--YQFYTGD-FLSAGYEARQ 660 +N + P + + +T P Y + D GY A Sbjct: 196 -----PRQWVNNGFAGWNGQARIEQPQEGYAIIMETTPPAPCYFIFVSDPAFDKGY-AFD 249 Query: 661 GFAIEPGRY-IDAINQENWKDCVTLKNGETYGSK 693 F +EP + D ++ D + L GE+ S+ Sbjct: 250 FFCLEPMSHAPDDHHRPEGGDLIALAPGESTTSE 283 >2GDZ-A nrPDB Length = 267 Score = 53.3 bits (126), Expect = 4e-07, Method: Composition-based stats. Identities = 31/138 (22%), Positives = 58/138 (42%), Gaps = 11/138 (7%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVAD-NLSNSTYDSVARLEVLTKHHIPFY 66 K+ LVTG A IG L+ G + D NL A E F Sbjct: 4 MVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALHEQFEPQKTLFI 63 Query: 67 EVDLCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGESTQIPLRYYHNNIL-GTVVLLE 120 + D+ D++ L F++ ++D +++ AG+ ++ + L+ +++ GT + L+ Sbjct: 64 QCDVADQQQLRDTFRKVVDHFGRLDILVNNAGV-NNEKNWEKTLQINLVSVISGTYLGLD 122 Query: 121 LMQQYNVSK---FVFSSS 135 M + N + + SS Sbjct: 123 YMSKQNGGEGGIIINMSS 140 >6NRP-A nrPDB Length = 263 Score = 52.5 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 27/148 (18%), Positives = 59/148 (39%), Gaps = 14/148 (9%) Query: 2 TAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKH 61 T L +S ++ +LVTG + IG ++L + G+D V + + V + Sbjct: 15 TENLYFQSMTRRILVTGSSRGIGKAIALQLAKAGFDVTVHARSRQAEAEQVVQEIQALGQ 74 Query: 62 HIPFYEVDLCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGE----STQIPLRYYHNNI 112 + + D+ +R+ ++++ ++ V+ AGL G + Q ++ Sbjct: 75 NSHYLMFDVNERQTVQQILEQDVEQHGGFYGVVLNAGLTHDGAFPALTDQDWDEVISTSL 134 Query: 113 LGTVVLLE-----LMQQYNVSKFVFSSS 135 G +L+ ++ + V SS Sbjct: 135 DGFYNVLKPLIMPMIHLRKGGRIVTLSS 162 >3V8B-A nrPDB Length = 283 Score = 51.4 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 30/152 (19%), Positives = 48/152 (31%), Gaps = 19/152 (12%) Query: 2 TAQLQSESTSK----IVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEV 57 T L +S + L+TG IG T + L +G + + Sbjct: 15 TENLYFQSMMNQPSPVALITGAGSGIGRATALALAADGVTVGALGRTRTEVEEVADEIVG 74 Query: 58 LTKHHIPFYEVDLCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGESTQI--P---LRY 107 I E D+ D + ++ +D V+ AG+ V P Sbjct: 75 AGGQAIAL-EADVSDELQMRNAVRDLVLKFGHLDIVVANAGINGVWAPIDDLKPFEWDET 133 Query: 108 YHNNILGTVVLLEL----MQQYNVSKFVFSSS 135 N+ GT + L L ++Q V SS Sbjct: 134 IAVNLRGTFLTLHLTVPYLKQRGGGAIVVVSS 165 >3V2G-A nrPDB Length = 271 Score = 51.4 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 36/184 (19%), Positives = 66/184 (35%), Gaps = 26/184 (14%) Query: 2 TAQLQSEST-------SKIVLVTGGAGYIGSHTVVEL-IENGYDCVVADNLSNSTYDSVA 53 T L +S K VTGG+ IG+ L +E + N + V+ Sbjct: 15 TENLYFQSMMTSISLAGKTAFVTGGSRGIGAAIAKRLALEGAAVALTYVNAAERAQAVVS 74 Query: 54 RLEVLTKHHIPFYEVDLCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGESTQIPLRYY 108 +E + D D + +E+ +E +D +++ AG+ + + + Sbjct: 75 EIEQAGGRAVA-IRADNRDAEAIEQAIRETVEALGGLDILVNSAGIWHSAPLEETTVADF 133 Query: 109 HNNILGTVVLLELMQQYNVSKFVFSSSATVY-GDATRFPNMIP-IPEECPLGPTNPYGHT 166 E+M + FV SA+ + GD R + + E P + Y + Sbjct: 134 D----------EVMAVNFRAPFVAIRSASRHLGDGGRIITIGSNLAELVPWPGISLYSAS 183 Query: 167 KYAI 170 K A+ Sbjct: 184 KAAL 187 >3UN1-A nrPDB Length = 260 Score = 50.2 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 22/141 (15%), Positives = 49/141 (34%), Gaps = 23/141 (16%) Query: 2 TAQLQSESTS----KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEV 57 T L +S K+V++TG + IG+ V + Y V + ++ Sbjct: 15 TENLYFQSMMRNQQKVVVITGASQGIGAGLVRAYRDRNYRVV----------ATSRSIKP 64 Query: 58 LTKHHIPFYEVDLCDRKGLEKVFKE-----YKIDSVIHFA----GLKAVGESTQIPLRYY 108 I D+ + +++ +E +IDS+++ A V + + Sbjct: 65 SADPDIHTVAGDISKPETADRIVREGIERFGRIDSLVNNAGVFLAKPFVEMTQEDYDHNL 124 Query: 109 HNNILGTVVLLELMQQYNVSK 129 N+ G + + + + Sbjct: 125 GVNVAGFFHITQRAAAEMLKQ 145 >4IIV-A nrPDB Length = 267 Score = 49.8 bits (117), Expect = 4e-06, Method: Composition-based stats. Identities = 28/164 (17%), Positives = 52/164 (31%), Gaps = 23/164 (14%) Query: 2 TAQLQSES--TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLT 59 T L +S S+ VLVTG + IG +L +G++ V + + V Sbjct: 15 TENLYFQSNAMSRSVLVTGASKGIGRAIARQLAADGFNIGVHYHRDAAGAQETLNAIVAN 74 Query: 60 KHHIPFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGE------------STQIPLRY 107 + D+ +R+ +V + H A V S Sbjct: 75 GGNGRLLSFDVANREQCREVLEHEIAQ---HGAWYGVVSNAGIARDAAFPALSNDDWDAV 131 Query: 108 YHNNILGTVVLLELMQ-----QYNVSKFVFSSS-ATVYGDATRF 145 H N+ +++ + + SS + V G+ + Sbjct: 132 IHTNLDSFYNVIQPCIMPMIGARQGGRIITLSSVSGVMGNRGQV 175 >3KZV-A nrPDB Length = 254 Score = 49.4 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 39/193 (20%), Positives = 70/193 (36%), Gaps = 30/193 (15%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 K++LVTG + IG V L D VV + + +L+ + D Sbjct: 1 MGKVILVTGVSRGIGKSIVDVLFSLDKDTVVYG--VARSEAPLKKLKEKYGDRFFYVVGD 58 Query: 70 LCDRKGLEKVFKE-----YKIDSVIHFAG-LKAVGESTQIPL----RYYHNNILGTVVLL 119 + + L+++ KIDS++ AG L+ V +I + + Y N V L+ Sbjct: 59 ITEDSVLKQLVNAAVKGHGKIDSLVANAGVLEPVQNVNEIDVNAWKKLYDINFFSIVSLV 118 Query: 120 ELM---QQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILND 176 + + VF SS + + YG +K A+ + Sbjct: 119 GIALPELKKTNGNVVFVSSDACNMYFSSWGA---------------YGSSKAALNHFAMT 163 Query: 177 LYNSDKKSWKFAI 189 L N +++ A+ Sbjct: 164 LANEERQVKAIAV 176 >5ILO-A nrPDB Length = 271 Score = 49.4 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 43/193 (22%), Positives = 71/193 (36%), Gaps = 33/193 (17%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENG-YDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 K +VTGGAG IG +L+ G + D N R T+ + ++D Sbjct: 15 GKNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEFVKLRAAHPTQS-VMIIKMD 73 Query: 70 LCDRKGLEKVFKEYK-----IDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQ 124 + ++KG+E ++E ID V++ AG+ + ++ T+++ Sbjct: 74 VANKKGVEATYEEIAKTFGNIDIVVNVAGI------------FNDKDVQRTLLV------ 115 Query: 125 YNVSKFVFSS-SATVY------GDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDL 177 N+ + S+ SA Y G NM + P+ YG TK I N L Sbjct: 116 -NLGGIINSTLSALPYMGKDNGGKGGIVVNMSSVVGLDPMFIIPVYGATKAGIINFTRCL 174 Query: 178 YNSDKKSWKFAIL 190 N Sbjct: 175 ANEKYYQRSGIKF 187 >1YXM-A nrPDB Length = 303 Score = 49.4 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 35/180 (19%), Positives = 71/180 (39%), Gaps = 29/180 (16%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVA----DNLSNSTYDSVARLEVLTKHHIPF 65 ++ +VTGGA IG V EL+E G + V+A + L ++ + A L + + Sbjct: 17 QGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIP 76 Query: 66 YEVDLCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGE----STQIPLRYYHNNILGTV 116 + ++ + + + + K KI+ +++ G + + S++ N+ GT Sbjct: 77 IQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTF 136 Query: 117 VLLELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTN------PYGHTKYAI 170 + + V+SS +G + ++P PL + Y TK Sbjct: 137 YMCKA---------VYSSWMKEHGG-SIVNIIVPTKAGFPLAVHSGAARAGVYNLTKSLA 186 >3A28-C nrPDB Length = 258 Score = 48.7 bits (114), Expect = 8e-06, Method: Composition-based stats. Identities = 25/123 (20%), Positives = 47/123 (38%), Gaps = 10/123 (8%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVA-RLEVLTKHHIPFYEV 68 SK+ +VTGGA IG +L +G+D VAD + +L F + Sbjct: 1 MSKVAMVTGGAQGIGRGISEKLAADGFDIAVADLPQQEEQAAETIKLIEAADQKAVFVGL 60 Query: 69 DLCDRKGLEKVFKE-----YKIDSVIHFAGLKAVG----ESTQIPLRYYHNNILGTVVLL 119 D+ D+ + E D +++ AG+ + + + + Y N+ + Sbjct: 61 DVTDKANFDSAIDEAAEKLGGFDVLVNNAGIAQIKPLLEVTEEDLKQIYSVNVFSVFFGI 120 Query: 120 ELM 122 + Sbjct: 121 QAA 123 >4AVY-A nrPDB Length = 242 Score = 48.7 bits (114), Expect = 1e-05, Method: Composition-based stats. Identities = 28/168 (16%), Positives = 65/168 (38%), Gaps = 18/168 (10%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 + VLVTGG+ IG+ ++ E G + V ++ + I E+D+ Sbjct: 11 GQQVLVTGGSSGIGAAIAMQFAELGAEVVALGLDADG-------VHAPRHPRIRREELDI 63 Query: 71 CDRKGLEKVFKEY-KIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSK 129 D + L+++F+ ++D +++ AG+ + + L + + + L M +++ Sbjct: 64 TDSQRLQRLFEALPRLDVLVNNAGIS--RDREEYDLATFER--VLRLNLSAAMLASQLAR 119 Query: 130 FVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDL 177 + + + + + Y +K AI + L Sbjct: 120 PLLAQRGGSILNIASMYSTFGSADRPA------YSASKGAIVQLTRSL 161 >5ITV-A nrPDB Length = 255 Score = 48.3 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 33/152 (21%), Positives = 64/152 (42%), Gaps = 19/152 (12%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 T K VL+TGGA IG V + + VVAD + + +++ R E + F + D Sbjct: 6 TDKTVLITGGASGIGYAAVQAFLGQQANVVVAD-IDEAQGEAMVRKE--NNDRLHFVQTD 62 Query: 70 LCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGESTQIPLRYYH----NNILG----TV 116 + D + + +D +I+ AG++ V ++ L ++ N+ G + Sbjct: 63 ITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELSDWNKVLQVNLTGMFLMSK 122 Query: 117 VLLELMQQYNVSKFVFSSSATVYGDATRFPNM 148 L+ M + + +V G +P++ Sbjct: 123 HALKHMLAAGKGNIIN--TCSV-GGLVAWPDI 151 >3WYE-A nrPDB Length = 256 Score = 48.3 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 30/171 (17%), Positives = 64/171 (37%), Gaps = 22/171 (12%) Query: 10 TSKIVLVTGGAGY-IGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEV 68 K+ LVTG AG IG + L+++G+ +AD + + + H + +V Sbjct: 1 MKKVALVTG-AGQGIGKAIALRLVKDGFAVAIADYNDATAKAVASEINQAGGHAVA-VKV 58 Query: 69 DLCDRKGLEKVFKE-----YKIDSVIHFAGLKAVG----ESTQIPLRYYHNNILGTVVLL 119 D+ DR + ++ D +++ AG+ + + + + Y N+ + Sbjct: 59 DVSDRDQVFAAVEQARKTLGGFDVIVNNAGIAQIKPLLEVTEEDLKQIYSVNVFSVFFGI 118 Query: 120 ELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAI 170 + + +G I + P+ + Y TK+A+ Sbjct: 119 QAAVEAFKK--------EGHGGKIINAASIAAIQGFPI--LSAYSTTKFAV 159 >4MOW-A nrPDB Length = 256 Score = 47.9 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 41/220 (18%), Positives = 77/220 (35%), Gaps = 39/220 (17%) Query: 7 SESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFY 66 S+ K+ +VTG + IG+ L + G VV S + D+V Sbjct: 10 SKLAGKVAIVTGASKGIGAAIAKALADEGAAVVVNYASSKAGADAVVSAITEAGGRAVAV 69 Query: 67 EVDLCDRKGLEKVFKE-----YKID------SVIHFAGLKAVGESTQIPLRYYHNNILGT 115 D+ +++ ++D V FA ++A+ E + R + N+ G Sbjct: 70 GGDVSKAADAQRIVDTAIETYGRLDVLVNNSGVYEFAPIEAITE--EHYRRQFDTNVFGV 127 Query: 116 VVLLELMQQY--NVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTN-PYGHTKYAIEN 172 ++ + ++ + + SS P + Y TK A++ Sbjct: 128 LLTTQAAVKHLGEGASIINISSVV----------------TSITPPASAVYSGTKGAVDA 171 Query: 173 ILNDLYNSDKKSWKFAILRYFNP-----IGAHPSGLIGED 207 I L + + + + NP G H +G+IG D Sbjct: 172 ITGVL--ALELGPRKIRVNAINPGMIVTEGTHSAGIIGSD 209 >5U9P-A nrPDB Length = 265 Score = 47.9 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 33/181 (18%), Positives = 61/181 (33%), Gaps = 24/181 (13%) Query: 1 MTAQLQ-SESTSKIVLVTG-GAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVL 58 MT L + L+TG G G IG L E G V+ D + ++AR Sbjct: 9 MTHALDRFRLDGRRALITGSGRG-IGLTLARGLAEAGAAIVINDR-NEEKAATLARRFRD 66 Query: 59 TKHHIPFYEVDLCDRKGLEKVFKEY-----KIDSVIHFAG-LKAVGESTQIPLRY---YH 109 D+ + + E+ ID +++ AG + P + Sbjct: 67 EGFAADHAVFDVAEHAQVRAAIDEFEARVGAIDILVNNAGIQRRAPLDAFEPDDWHALMR 126 Query: 110 NNILGTVVLLELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYA 169 N+ G + + + ++ +++ + N+ + E PY TK A Sbjct: 127 VNLDGVFNVAQAVARHMIAR-----------GHGKIINICSVQSELARPTIAPYAATKGA 175 Query: 170 I 170 + Sbjct: 176 V 176 >1K2W-A nrPDB Length = 256 Score = 47.5 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 25/139 (17%), Positives = 54/139 (38%), Gaps = 18/139 (12%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 K L+TG A IG + G +AD + + A + +D+ Sbjct: 5 GKTALITGSARGIGRAFAEAYVREGARVAIADINLEAARATAAEI----GPAACAIALDV 60 Query: 71 CDRKGLEKVFKE-----YKIDSVIHFAGL----KAVGESTQIPLRYYHNNILGTVVLLEL 121 D+ +++ E ID +++ A L V + + R + N+ GT+ +++ Sbjct: 61 TDQASIDRCVAELLDRWGSIDILVNNAALFDLAPIVEITRESYDRLFAINVSGTLFMMQA 120 Query: 122 MQQYNVS-----KFVFSSS 135 + + ++ K + +S Sbjct: 121 VARAMIAGGRGGKIINMAS 139 >1QYC-A nrPDB Length = 308 Score = 47.5 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 25/128 (19%), Positives = 47/128 (36%), Gaps = 20/128 (15%) Query: 9 STSKIVLVTGGAGYIGSHTVVELIENGYDC--VVADNLSNSTYDSVARLEVLTKHHIPFY 66 S S+I+L+ G GYIG H ++ G+ +V ++ ++S + LE Sbjct: 3 SRSRILLI-GATGYIGRHVAKASLDLGHPTFLLVRESTASSNSEKAQLLESFKASGANIV 61 Query: 67 EVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN 126 + D L + K +D VI G + +++ +++ Sbjct: 62 HGSIDDHASLVEAVKN--VDVVISTVGSLQIESQV---------------NIIKAIKEVG 104 Query: 127 VSKFVFSS 134 K F S Sbjct: 105 TVKRFFPS 112 >4B4O-A nrPDB Length = 298 Score = 47.1 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 56/325 (17%), Positives = 91/325 (28%), Gaps = 80/325 (24%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLC 71 VLV GG G+IG+ L G++ + + L Sbjct: 1 MRVLVGGGTGFIGTALTQLLNARGHEVTLVSRKPGPGRITWDELAASGLP---------- 50 Query: 72 DRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPL----RYYHNNILG-----TVVLLELM 122 D+ ++ A GE+ PL + +LG T +L + + Sbjct: 51 ------------SCDAAVNLA-----GENILNPLRRWNETFQKEVLGSRLETTQLLAKAI 93 Query: 123 QQY-NVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYG--HTKYAIENILNDLYN 179 + K + Y + E+ P G + + TK L Sbjct: 94 TKAPQPPKAWVLVTGVAYYQPSLTAE---YDEDSPGGDFDFFSNLVTK---WEAAARLPG 147 Query: 180 SDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDS 239 + ++R +G G +G + LLP+ G Sbjct: 148 DSTRQ---VVVRSGVVLG-RGGGAMG-------HMLLPFRL-------------GLGGPI 183 Query: 240 RDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKAS 299 G +IH+ DLA AL+ + G+ +T E F A Sbjct: 184 GSGHQFFPWIHIGDLAGILTHALEANHVHGVLNGVAP-------SSATNAEFAQTFGAAL 236 Query: 300 G----IDLPYKVTGRRAGDVLNLTA 320 G I LP V G + Sbjct: 237 GRRAFIPLPSAVVQAVFGRQRAIML 261 >5VT6-A nrPDB Length = 269 Score = 47.1 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 22/92 (23%), Positives = 38/92 (41%), Gaps = 5/92 (5%) Query: 7 SESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFY 66 S ++ VTGG G +G+ L + G V+ + N + E Y Sbjct: 21 SMQAKRVAFVTGGMGGLGAAISRRLHDAGMAVAVSHSERNDHVSTWLMHERDAGRDFKAY 80 Query: 67 EVDLCDRKGLEKVFKE-----YKIDSVIHFAG 93 VD+ D + E+ ++ K+D +I+ AG Sbjct: 81 AVDVADFESCERCAEKVLADFGKVDVLINNAG 112 >4K6F-A nrPDB Length = 255 Score = 47.1 bits (110), Expect = 3e-05, Method: Composition-based stats. Identities = 28/139 (20%), Positives = 55/139 (39%), Gaps = 13/139 (9%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 T +I +VTGG G +G + L + G+ VV + +N+ D Y VD Sbjct: 10 TKRIAVVTGGMGGLGEAVSIRLNDAGHRVVVTYSPNNTGADRWLTEMHAAGREFHAYPVD 69 Query: 70 LCDRKGLEKVFKE-----YKIDSVIHFAG-------LKAVGESTQIPLRYYHNNILG-TV 116 + D ++ ++ +D +++ AG K + +R +++ T Sbjct: 70 VADHDSCQQCIEKIVRDVGPVDILVNNAGITRDMTLRKLDKVNWDAVIRTNLDSVFNMTK 129 Query: 117 VLLELMQQYNVSKFVFSSS 135 + + M + + V SS Sbjct: 130 PVCDGMVERGWGRIVNISS 148 >2V6G-A nrPDB Length = 364 Score = 46.7 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 42/285 (14%), Positives = 89/285 (31%), Gaps = 41/285 (14%) Query: 11 SKIVLVTGGAGYIGSHTVVEL-IENGY-DCVVADNLSNSTYDSVARLEVLTKHHIPFYEV 68 S + L+ G G IG+ L + + ++ T + + I + + Sbjct: 1 SSVALIVGVTGIIGNSLAEILPLADTPGGPWKVYGVARRTRPAWHE-----DNPINYVQC 55 Query: 69 DLCD-RKGLEKVFKEYKIDSVIH--FAGLKAVGESTQIPLRYYHNNILGTV----VLLEL 121 D+ D K+ + V + +A E+ + + + N + + L + Sbjct: 56 DISDPDDSQAKLSPLTDVTHVFYVTWANRSTEQENCEANSKMFRNVLDAVIPNCPNLKHI 115 Query: 122 MQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECP-LGPTNPYGHTKYAIENILNDLYNS 180 Q + + YG P E+ P L N Y + +L ++ Sbjct: 116 SLQTG--RKHYMGPFESYGKIESHDP--PYTEDLPRLKYMNFYYD---LEDIMLEEVEKK 168 Query: 181 DKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGR-REKLYIFGDDYDS 239 + +W P + G P + N + A+ + K+ F + Sbjct: 169 EGLTWSV----------HRPGNIFGFSPYSMMNLVGTLCVYAAICKHEGKVLRFTGCKAA 218 Query: 240 RDGTPIRDYIHVVDLAKGHIAALQYLEAYNENEGLCREWNLGSGK 284 DG D + + A ++ A + +N+ +G Sbjct: 219 WDGYS--------DCSDADLIAEHHIWAAVDPYAKNEAFNVSNGD 255 >6G2J-P nrPDB Length = 377 Score = 46.7 bits (109), Expect = 4e-05, Method: Composition-based stats. Identities = 19/126 (15%), Positives = 46/126 (36%), Gaps = 10/126 (7%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 + + V G G++G + V L G ++ + + L + + F E D Sbjct: 52 SGVVATVFGATGFLGRYVVNHLGRMGSQVIIPYRCDVYDIMHLRLMGDLGQ--LTFLEWD 109 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVV-LLELMQQYNVS 128 D+ + K + + VI+ +G + + + + + + ++ V Sbjct: 110 ARDKDSIRKAVQHSNV--VINL-----IGREWETRNFDFEDVFVNIPRAIAQASKEAGVE 162 Query: 129 KFVFSS 134 +F+ S Sbjct: 163 RFIHVS 168 >2QYS-A nrPDB Length = 318 Score = 46.3 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 23/123 (18%), Positives = 47/123 (38%), Gaps = 21/123 (17%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 +L+ GG GYIG+H V ++ G+ V + L+ + + Sbjct: 10 MKSKILIFGGTGYIGNHMVKGSLKLGHPTYV---FTRPNSSKTTLLDEFQSLGAIIVKGE 66 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQY-NVS 128 L + + L ++ K K+D VI + + + +LE ++ N+ Sbjct: 67 LDEHEKLVELMK--KVDVVISALAFPQILDQFK---------------ILEAIKVAGNIK 109 Query: 129 KFV 131 +F+ Sbjct: 110 RFL 112 >6CI9-A nrPDB Length = 259 Score = 45.6 bits (106), Expect = 7e-05, Method: Composition-based stats. Identities = 37/180 (20%), Positives = 62/180 (34%), Gaps = 28/180 (15%) Query: 3 AQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHH 62 + + + + +VTGG+ IG G D V+ + +VA L T+ Sbjct: 1 SHMFTSLEGRSAIVTGGSKGIGRGIAETFANAGVDVVITGRNQDDLDRTVADLS-GTRGK 59 Query: 63 IPFYEVDLCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGESTQIPLRYYH----NNIL 113 + D+ D + + E +D V AG+ G + N Sbjct: 60 VTAVRADVTDPEDARRTVAETVSRHGGLDIVCANAGIFPSGRLEDLTPDDIEQVLGVNFK 119 Query: 114 GTVVLLELMQQY----NVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYA 169 GTV +++ Q + V +SS T G T +P + YG +K A Sbjct: 120 GTVYIVQAALQALTASGHGRVVVTSSIT--GPITGYP------------GWSHYGASKAA 165 >3WOH-A nrPDB Length = 251 Score = 45.6 bits (106), Expect = 8e-05, Method: Composition-based stats. Identities = 29/150 (19%), Positives = 62/150 (41%), Gaps = 16/150 (10%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDC-VVADNLSNSTYDSVARLEVLTKHHIPFYEV 68 + K+ LVTGG+ +G + L +G +V + +S ++ +E L Y Sbjct: 10 SGKVALVTGGSRGLGRAMALRLARDGAAVAIVYVSDDSSAKETQGEIERLGGTA-RSYRC 68 Query: 69 DLCDRKGLEKVFKE-----YKIDSVIHFAGLK--AVGESTQIPLRY--YHNNILGTVVLL 119 D+ D + + + K +D +++ AG+ + S + + N+ G + + Sbjct: 69 DVSDAEQVTRCVKAVTADLGPVDILVNNAGIIRDGLAASIKDEDYDAVMNTNLKGAFLFI 128 Query: 120 ELMQQYNVSK----FVFSSS-ATVYGDATR 144 + + K + SS + V+G A + Sbjct: 129 KACYFGFIRKRSGSIINISSVSGVFGSAGQ 158 >4IIN-A nrPDB Length = 271 Score = 45.2 bits (105), Expect = 1e-04, Method: Composition-based stats. Identities = 33/202 (16%), Positives = 70/202 (34%), Gaps = 28/202 (13%) Query: 2 TAQLQSES-----TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLE 56 T L +S T K VL+TG + IG+ L G + + D++ Sbjct: 15 TENLYFQSNAMQFTGKNVLITGASKGIGAEIAKTLASMGLKVWINYRSNAEVADALKNEL 74 Query: 57 VLTKHHIPFYEVDLCDRKGLEKVFK-----EYKIDSVIHFAGLKAVGESTQIPLRYYH-- 109 + + D + + + + +++ AG+ + ++ +H Sbjct: 75 EEKGYKAAVIKFDAASESDFIEAIQTIVQSDGGLSYLVNNAGVVRDKLAIKMKTEDFHHV 134 Query: 110 --NNILG-TVVLLELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHT 166 NN+ + E ++ + S+F G ++I E +G TN Y + Sbjct: 135 IDNNLTSAFIGCREALKVMSKSRF---------GSVVNVASIIG--ERGNMGQTN-YSAS 182 Query: 167 KYAIENILNDL-YNSDKKSWKF 187 K + + Y ++ +F Sbjct: 183 KGGMIAMSKSFAYEGALRNIRF 204 >2PNF-A nrPDB Length = 248 Score = 44.8 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 27/144 (18%), Positives = 49/144 (34%), Gaps = 13/144 (9%) Query: 5 LQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIP 64 ++ + K+ LVTG IG +L G ++ + Sbjct: 1 MEIKLQGKVSLVTGSTRGIGRAIAEKLASAGSTVIITGTSGERAKAVAEEIANKYGVKAH 60 Query: 65 FYEVDLCDRKGLEKVFKEY-----KIDSVIHFAG----LKAVGESTQIPLRYYHNNILGT 115 E++L + + K F+E ID +++ AG + S N+ GT Sbjct: 61 GVEMNLLSEESINKAFEEIYNLVDGIDILVNNAGITRDKLFLRMSLLDWEEVLKVNLTGT 120 Query: 116 VVL----LELMQQYNVSKFVFSSS 135 ++ L M + + V SS Sbjct: 121 FLVTQNSLRKMIKQRWGRIVNISS 144 >3VZS-A nrPDB Length = 257 Score = 44.8 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 27/140 (19%), Positives = 50/140 (35%), Gaps = 13/140 (9%) Query: 9 STSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEV 68 ST +I VTGG G IG+ L ++G+ V ++ + + E Sbjct: 12 STQRIAYVTGGMGGIGTAICQRLAKDGFRVVAGCGPNSPRREKWLEQQKALGFDFIASEG 71 Query: 69 DLCDRKGLEKVFKEYK-----IDSVIHFAG----LKAVGESTQIPLRYYHNNILG----T 115 ++ D + F + K +D +I+ AG + + N+ T Sbjct: 72 NVADWDSTKTAFDKVKSEVGEVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVT 131 Query: 116 VVLLELMQQYNVSKFVFSSS 135 +++ M + V SS Sbjct: 132 KQVIDGMADRGWGRIVNISS 151 >2NM0-A nrPDB Length = 253 Score = 44.8 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 27/139 (19%), Positives = 47/139 (33%), Gaps = 25/139 (17%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 S+ VLVTGG IG + G + +A + D Sbjct: 20 MSRSVLVTGGNRGIGLAIARAFADAGDKVAITYRSGEPPEGFLA------------VKCD 67 Query: 70 LCDRKGLEKVFKE-----YKIDSVIHFAG----LKAVGESTQIPLRYYHNNILGTVVLL- 119 + D + +E+ +KE ++ +I AG + S + N+ GT ++ Sbjct: 68 ITDTEQVEQAYKEIEETHGPVEVLIANAGVTKDQLLMRMSEEDFTSVVETNLTGTFRVVK 127 Query: 120 ---ELMQQYNVSKFVFSSS 135 M + + V SS Sbjct: 128 RANRAMLRAKKGRVVLISS 146 >3U9L-A nrPDB Length = 324 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 25/126 (19%), Positives = 49/126 (38%), Gaps = 13/126 (10%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVV----ADNLSNSTYDSVARLEVLTKHHIPF 65 + KI+L+TG + G T L G+ + S +++A + Sbjct: 4 SKKIILITGASSGFGRLTAEALAGAGHRVYASMRDIVGRNASNVEAIAGFARDNDVDLRT 63 Query: 66 YEVDLCDRKGLEKVFK-----EYKIDSVIHFAGLKAVGESTQ-IPLRY---YHNNILGTV 116 E+D+ + +++ + +ID +IH AG G + P ++ Y N+L T Sbjct: 64 LELDVQSQVSVDRAIDQIIGEDGRIDVLIHNAGHMVFGPAEAFTPEQFAELYDINVLSTQ 123 Query: 117 VLLELM 122 + Sbjct: 124 RVNRAA 129 >1GEG-A nrPDB Length = 256 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 33/176 (18%), Positives = 68/176 (38%), Gaps = 32/176 (18%) Query: 10 TSKIVLVTGGAGY-IGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEV 68 K+ LVTG AG IG + L+++G+ +AD + + + H + +V Sbjct: 1 MKKVALVTG-AGQGIGKAIALRLVKDGFAVAIADYNDATAKAVASEINQAGGHAVA-VKV 58 Query: 69 DLCDRKGLEKVFKE-----YKIDSVIHFA--GLKAVGEST--QIPLRYYHNNILGTVVLL 119 D+ DR + ++ D +++ A ES +I + Y+ N+ G + + Sbjct: 59 DVSDRDQVFAAVEQARKTLGGFDVIVNNAGVAPSTPIESITPEIVDKVYNINVKGVIWGI 118 Query: 120 ELM-----QQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAI 170 + ++ + K + + S + PE Y +K+A+ Sbjct: 119 QAAVEAFKKEGHGGKIINACSQA---------GHVGNPE------LAVYSSSKFAV 159 >3WTC-A nrPDB Length = 262 Score = 44.4 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 42/234 (17%), Positives = 80/234 (34%), Gaps = 28/234 (11%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 + KI VTG A IG + L ++G D ++ D ++ ++ +E L + + D Sbjct: 7 SGKIAAVTGAAQGIGKAIALRLAKDGADVILLDVKQDTLAETAKEVEALGRRAVALT-AD 65 Query: 70 LCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGESTQ-IPLR---YYHNNILGTVVLLE 120 + +R + +D +++ AG+ V P + N+ G + ++ Sbjct: 66 ISNRDQFRSTLADAAKTLGGLDIMVNNAGICQVKPILDIEPAEIEKIFSINVQGVLWGMQ 125 Query: 121 LMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNS 180 K G + N I Y TK+A + L S Sbjct: 126 AAATLFKEK----------GTKGKIINACSIAGHEGYPLLGAYSATKFA----VRALTQS 171 Query: 181 DKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFG 234 K + + N G++G D + + + +G K Y+ G Sbjct: 172 AAKELASSGI-TVNSYCP---GIVGTDMWVTIDKRMAEITGTEIGATYKKYVEG 221 >3Q1N-A nrPDB Length = 294 Score = 44.0 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 57/318 (17%), Positives = 107/318 (33%), Gaps = 47/318 (14%) Query: 376 VTIGAGTRFQATFANLGASIVDLKVNGQSVVLGYENEEGYLNPDSAYIG--ATIGRYA-N 432 +TI ++F+A A GA + QS+V +N E D + A I + Sbjct: 3 ITIEN-SKFKAGIAERGAEL-------QSLVNKADNYEYVWTGDKTFWNRHAPILFPSIG 54 Query: 433 RISKGKFSLCNKDYQLTVNNGVNANHSSIGSFHRKRFLGPIIQNPSKDVFTAEYMLIDN- 491 + ++ ++ L K Y + H + K + N Sbjct: 55 KSNQDQYRLGAKTY-------PMSQHGFARDYDF--------DVSDKSDSAVTFTQHQNA 99 Query: 492 EKDTEFPGDLLVTIQYTVNVAQKSLEMVYKGKLTAGEATPINLTNHSYFNLNKPYGDTIE 551 E +FP + + + Y + L + Y ++ P L H FN+ + + Sbjct: 100 ETLKKFPFEYTLAVTYMLTDG--GLSVHYTVTNDDSKSMPFALGFHPAFNVGLKADGSFD 157 Query: 552 GTEIMVRSKKSVDVDKNMIPTGNIVDREIATFNSTKPTVLGPKNPQFDCCFVVDENAKPS 611 ++ V S + + I G + R + P G + P + + Sbjct: 158 DYDLTVEPLNS-PLQRFGI--GPVPFRNGDVEDI--PGAEGNRLP-LTHDLLDGGLVILA 211 Query: 612 QINTLNNELTLIVKAFHPDSNITLEVLSTEPTYQFYTGDFLSAGYEARQGFAIEPGRYID 671 N+ + TL H D +ITL++ S P ++ + ++ A+EP + Sbjct: 212 --NSEIAKATLASP--HHDHSITLDI-SDFPYLTIWSPE-----HKKAPFIAVEP--FDG 259 Query: 672 AINQENWKDCVTLKNGET 689 +Q K G T Sbjct: 260 LPDQAGEPTDWYTKLGNT 277 >5GUP-L nrPDB Length = 377 Score = 43.6 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 29/166 (17%), Positives = 60/166 (36%), Gaps = 20/166 (12%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 + + V G G++G + V L G +V YD++ + I F E + Sbjct: 52 SGIVATVFGATGFLGRYVVNHLGRMGSQVIVPY--RCEPYDTMHLRPMGDLGQIIFMEWN 109 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVV-LLELMQQYNVS 128 D+ + KV + + VI+ VG + + + + + ++ ++ V Sbjct: 110 GKDKDSIRKVVEHSNV--VINL-----VGREWETKNFDFEDVFVKIPHAIAQVSKEAGVE 162 Query: 129 KFVFSS-------SATVYGDATRFPNMI---PIPEECPLGPTNPYG 164 K + S S + Y + PE + P++ +G Sbjct: 163 KLIHISHLNADIKSPSRYLRSKAVGEKEVRAAFPEATIIKPSDIFG 208 >1N5D-A nrPDB Length = 288 Score = 43.6 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 48/290 (16%), Positives = 90/290 (31%), Gaps = 56/290 (19%) Query: 9 STSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEV 68 S +++ LVTG IG V +L VV + + + F+++ Sbjct: 2 SNTRVALVTGANKGIGFAIVRDLCRQFAGDVVLTARDVARGQAAVKQLQAEGLSPRFHQL 61 Query: 69 DLCDRKGLEKVFK-----EYKIDSVIHFAGLKAVGESTQ----IPLRYYHNNILGTVV-- 117 D+ D + + + +D +++ A + ++ N +GT Sbjct: 62 DIIDLQSIRALCDFLRKEYGGLDVLVNNAAIAFQLDNPTPFHIQAELTMKTNFMGTRNVC 121 Query: 118 --LLELMQQYNVSKFVFSSS-------ATVYGDATRFPNMIPIPEECPLGPTN------- 161 LL L++ + V SS + + I EE +G N Sbjct: 122 TELLPLIKPQG--RVVNVSSTEGVRALNECSPELQQKFKSETITEEELVGLMNKFVEDTK 179 Query: 162 ------------PYGHTKYAIENILNDLYNSDKKSWKFAILRYFNPI--GAHPSGLIGED 207 YG TK + +L+ +Y + + N G + + G Sbjct: 180 NGVHRKEGWSDSTYGVTKIGVS-VLSRIYARKLREQRAGDKILLNACCPGWVRTDMGGPK 238 Query: 208 PLGIPN---------NLLPYMAQVAVGR---REKLYIFGDDYDSRDGTPI 245 P LLP A+ G+ +K+ +G +S Sbjct: 239 APKSPEVGAETPVYLALLPSDAEGPHGQFVTDKKVVEWGVPPESYPWVNA 288 >3PXX-A nrPDB Length = 287 Score = 43.6 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 55/269 (20%), Positives = 88/269 (32%), Gaps = 34/269 (12%) Query: 10 TSKIVLVTGGA-GYIGSHTVVELIENGYDCVVADN----------LSNSTYDSVARLEVL 58 K+VLVTGGA G SH V L E G D ++ D L+ S A LEV Sbjct: 9 QDKVVLVTGGARGQGRSHAVK-LAEEGADIILFDICHDIETNEYPLATSRDLEEAGLEVE 67 Query: 59 TKHHIPF-YEVDLCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGES--TQIPLRYYHN 110 + EVD+ DR + + K+D V+ AG+ +G Q + Sbjct: 68 KTGRKAYTAEVDVRDRAAVSRELANAVAEFGKLDVVVANAGICPLGAHLPVQAFADAFDV 127 Query: 111 NILGTVVLLELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAI 170 + +G + + Y S ++ +V G + P G Y + K + Sbjct: 128 DFVGVINTVHAALPYLTSGASIITTGSVAGLIAAAQPPGAGGPQGPGGAG--YSYAKQLV 185 Query: 171 ENILNDLYNSDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKL 230 ++ L +R N I + + P + A R + L Sbjct: 186 DSYTLQL----AAQLAPQSIR-ANVIHPTNVNTDMLNSAPMYRQFRPDLE--APSRADAL 238 Query: 231 YIFGDDYDSRDGTPIRDYIHVVDLAKGHI 259 F Y+ D++ Sbjct: 239 LAFPAMQAMPTP-----YVEASDISNAVC 262 >3RWB-A nrPDB Length = 247 Score = 43.3 bits (100), Expect = 4e-04, Method: Composition-based stats. Identities = 26/147 (17%), Positives = 49/147 (33%), Gaps = 18/147 (12%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 K LVTG A IG L +G +V+D + D+ Sbjct: 6 GKTALVTGAAQGIGKAIAARLAADGATVIVSDI----NAEGAKAAAASIGKKARAIAADI 61 Query: 71 CDRKGLEKVFKEYK-----IDSVIHFAG-LKAV---GESTQIPLRYYHNNILGTVVLLEL 121 D ++ +F E + ID +++ A + V + N+ GT ++ Sbjct: 62 SDPGSVKALFAEIQALTGGIDILVNNASIVPFVAWDDVDLDHWRKIIDVNLTGTFIVTRA 121 Query: 122 ----MQQYNVS-KFVFSSSATVYGDAT 143 M+ + + + +S T + Sbjct: 122 GTDQMRAAGKAGRVISIASNTFFAGTP 148 >3DCD-A nrPDB Length = 307 Score = 42.9 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 43/266 (16%), Positives = 89/266 (33%), Gaps = 33/266 (12%) Query: 429 RYANRISKGKFSLCNKDYQLTVNNGVNANHSSIGSFHRKRFLGPIIQNPSKDVFTAEYML 488 R+ +++ K Y L G R ++N +K+ T ++L Sbjct: 51 PIVGRLKNDEYTYKGKTYHL-------------GQHGFARNADFEVENHTKESIT--FLL 95 Query: 489 IDNEKDTE-FPGDLLVTIQYTVNVAQKSLEMVYKGKLTAGEATPINLTNHSYFNLNKPYG 547 DNE+ + +P + Y N+ LE + + E + H FNL +G Sbjct: 96 KDNEETRKVYPFKFEFRVNY--NLMNNLLEENFSVVNKSDETMIFGVGGHPGFNLPTDHG 153 Query: 548 DTIEGTEIMVRSKKSVDVDKNMIPTGNI-VDREIATFNSTKPTVLGPKNPQFDCCFVVDE 606 + E + V + IP + +D + T + + D + + Sbjct: 154 ENKEDFYFDMHPS----VTRVRIPLKDASLDWNNRSLAPTDSLIALSDDLFKDDALIYEL 209 Query: 607 NAKPSQINTLNNELTLIVKAFHPDSNITLEVLSTEPTYQFYTGDFLSAGYEARQGFAIEP 666 ++++ ++ V + + + S P T +++ E G A Sbjct: 210 RGNDNKVSLRTDKNKFHVNVWT-RDAPFVGIWSQYPK----TDNYVCI--EPWWGIA--- 259 Query: 667 GRYIDAINQENWKDCVTLKNGETYGS 692 R + E+ LK G+ + + Sbjct: 260 DRDDADGDLEHKYGMNHLKPGKEFQA 285 >4E6P-A nrPDB Length = 259 Score = 42.9 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 26/142 (18%), Positives = 45/142 (31%), Gaps = 18/142 (12%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYE 67 K L+TG A IG + G +AD + A + + Sbjct: 5 RLEGKSALITGSARGIGRAFAEAYVREGATVAIADIDIERARQAAAEI----GPAAYAVQ 60 Query: 68 VDLC-----DRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHN----NILGTVVL 118 +D+ D V +D +++ A L + +I Y N+ GT+ Sbjct: 61 MDVTRQDSIDAAIAATVEHAGGLDILVNNAALFDLAPIVEITRESYEKLFAINVAGTLFT 120 Query: 119 LELM-----QQYNVSKFVFSSS 135 L+ Q K + +S Sbjct: 121 LQAAARQMIAQGRGGKIINMAS 142 >5OVL-A nrPDB Length = 300 Score = 42.5 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 27/168 (16%), Positives = 51/168 (30%), Gaps = 46/168 (27%) Query: 2 TAQLQSEST---------------------SKIVLVTGGAGYIGSHTVVELIENGYDCVV 40 T L + S+ VLVTGG IG L +G+ V Sbjct: 38 TENLYFQGMTVTDNPADTAGEATAGRPAFVSRSVLVTGGNRGIGLAIARRLAADGHKVAV 97 Query: 41 ADNLSNSTYDSVARLEVLTKHHIPFYEVDLCDRKGLEKVFKE-----YKIDSVIHFAGLK 95 + + D+ D +++ FKE ++ ++ AG+ Sbjct: 98 ------------THRGSGAPDDLFGVQCDVTDSAAVDRAFKEVEEHQGPVEVLVANAGIS 145 Query: 96 ----AVGESTQIPLRYYHNNILGTVVLLE----LMQQYNVSKFVFSSS 135 + + + + N+ G + MQ+ + +F S Sbjct: 146 KDAFLMRMTEERFEEVINTNLTGAFRCAQRASRTMQRKRFGRIIFIGS 193 >1UZM-A nrPDB Length = 247 Score = 42.5 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 27/138 (19%), Positives = 51/138 (36%), Gaps = 25/138 (18%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 S+ VLVTGG IG L +G+ V + EVD+ Sbjct: 15 SRSVLVTGGNRGIGLAIAQRLAADGHKVAV------------THRGSGAPKGLFGVEVDV 62 Query: 71 CDRKGLEKVF-----KEYKIDSVIHFAGLKA----VGESTQIPLRYYHNNILGTVVLLE- 120 D +++ F + ++ ++ AGL A + + + + + N+ G + + Sbjct: 63 TDSDAVDRAFTAVEEHQGPVEVLVSNAGLSADAFLMRMTEEKFEKVINANLTGAFRVAQR 122 Query: 121 ---LMQQYNVSKFVFSSS 135 MQ+ + +F S Sbjct: 123 ASRSMQRNKFGRMIFIGS 140 >4CQL-A nrPDB Length = 261 Score = 42.5 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 43/267 (16%), Positives = 83/267 (31%), Gaps = 41/267 (15%) Query: 1 MTAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTK 60 M +QLQ+ S + LVTG IG V L G D + ++V L Sbjct: 1 MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGS 60 Query: 61 HHIPF------YEVDLCDRKGLEKVFKEYK------IDSVIHFAG----LKAVGESTQIP 104 P ++ D+ + + + ++ + V+ AG + S Sbjct: 61 KEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDW 120 Query: 105 LRYYHNNILGTVVLLELMQQYNVSK-----FVFSSSATVYGDATRFPNMIPIPEECPLGP 159 + N+ GT ++ + Q VS + SS + G Sbjct: 121 DKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISS--IVGKVGNVGQTN---------- 168 Query: 160 TNPYGHTKYAIENILNDLYNSDKKSWKFAILRYFNPI-GAHPSGLIGEDPLGIPNNLLPY 218 Y +K + L + + +R + + G + + + P + + + Sbjct: 169 ---YAASKAG----VIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEM 221 Query: 219 MAQVAVGRREKLYIFGDDYDSRDGTPI 245 + +G E + S D I Sbjct: 222 IPMGHLGDPEDVADVVAFLASEDSGYI 248 >1BDB-A nrPDB Length = 277 Score = 42.5 bits (98), Expect = 7e-04, Method: Composition-based stats. Identities = 55/297 (18%), Positives = 100/297 (33%), Gaps = 47/297 (15%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYE 67 + + VL+TGGA +G V + G V D + + +A LE ++ Sbjct: 2 KLKGEAVLITGGASGLGRALVDRFVAEGAKVAVLDK----SAERLAELETDHGDNVLGIV 57 Query: 68 VDLCDRKGLEKVFKE-----YKIDSVIHFAG-----LKAVG---ESTQIP-LRYYHNNIL 113 D+ + ++ KID++I AG V ES +H N+ Sbjct: 58 GDVRSLEDQKQAASRCVARFGKIDTLIPNAGIWDYSTALVDLPEESLDAAFDEVFHINVK 117 Query: 114 GTVVLLELMQQYNVS---KFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAI 170 G + ++ V+ +F+ S + P G Y K+AI Sbjct: 118 GYIHAVKACLPALVASRGNVIFTISNAGFY---------------PNGGGPLYTAAKHAI 162 Query: 171 ENILNDLYNSDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKL 230 ++ +L + + G S L G LG+ + + + + + L Sbjct: 163 VGLVRELAFELAPYVRVNGV----GSGGINSDLRGPSSLGMGSKAISTVPLADMLKSV-L 217 Query: 231 YIFGDDYDSRDGTPIRDYIHVVDLAKGHIA-ALQYLEAYNENEGLCREWNLGSGKGS 286 I G + + T +V +G A A L Y+ G+ ++ G Sbjct: 218 PI-GRMPEVEEYTGA----YVFFATRGDAAPATGALLNYDGGLGVRGFFSGAGGNDL 269 >1QYD-A nrPDB Length = 313 Score = 42.5 bits (98), Expect = 7e-04, Method: Composition-based stats. Identities = 29/123 (23%), Positives = 50/123 (40%), Gaps = 19/123 (15%) Query: 13 IVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVL---TKHHIPFYEVD 69 VL+ GG GYIG V I G+ V ++ ++++L + E Sbjct: 6 RVLIVGGTGYIGKRIVNASISLGHPTYVL--FRPEVVSNIDKVQMLLYFKQLGAKLIEAS 63 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQY-NVS 128 L D + L K ++D VI + L S IL + L+E +++ N+ Sbjct: 64 LDDHQRLVDALK--QVDVVI--SALAGGVLSHH---------ILEQLKLVEAIKEAGNIK 110 Query: 129 KFV 131 +F+ Sbjct: 111 RFL 113 >3D3W-A nrPDB Length = 244 Score = 42.1 bits (97), Expect = 8e-04, Method: Composition-based stats. Identities = 39/221 (17%), Positives = 81/221 (36%), Gaps = 24/221 (10%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 + VLVTG IG TV L G VVA + + + DS+ R I VDL Sbjct: 7 GRRVLVTGAGKGIGRGTVQALHATG-ARVVAVSRTQADLDSLVR----ECPGIEPVCVDL 61 Query: 71 CDRKGLEKVFKEYKI-DSVIHFAG----LKAVGESTQIPLRYYHNNILGTVVLLELMQQY 125 D + E+ D +++ A + + + R + N+ + + +++ + Sbjct: 62 GDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARG 121 Query: 126 NVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSW 185 +++ G N+ + + + Y TK A++ + + + Sbjct: 122 LIAR----------GVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTK--VMALELGP 169 Query: 186 KFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGR 226 + NP S +G+ P+ + ++ +G+ Sbjct: 170 HKIRVNAVNPTVVMTS--MGQATWSDPHKAKTMLNRIPLGK 208 >2HSD-A nrPDB Length = 253 Score = 41.7 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 33/173 (19%), Positives = 62/173 (35%), Gaps = 32/173 (18%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYE 67 + + K V++TGGA +G+ + + G V+AD L + L + Sbjct: 2 DLSGKTVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATAREL----GDAARYQH 57 Query: 68 VDLC---DRKGLEKVFKE--YKIDSVIHFAGLK----AVGESTQIPLRYYHNNILGTV-- 116 +D+ D + + +E +D +++ AG+ ES + + N+ G Sbjct: 58 LDVTIEEDWQRVVAYAREEFGSVDGLVNNAGISTGMFLETESVERFRKVVEINLTGVFIG 117 Query: 117 --VLLELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTK 167 ++ M+ V SSA L T+ YG +K Sbjct: 118 MKTVIPAMKDAGGGSIVNISSAAGLMG---------------LALTSSYGASK 155 >3DWF-A nrPDB Length = 276 Score = 41.7 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 37/180 (20%), Positives = 61/180 (33%), Gaps = 19/180 (10%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYE 67 K V+VTG + IG L + G VV + VAR L + Sbjct: 8 MLQGKKVIVTGASKGIGREIAYHLAKMGAHVVVTARSKEALQKVVARCLELGAASAHYIA 67 Query: 68 VDLCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELM 122 + D E+ E +D +I L V L ++H I + + M Sbjct: 68 GSMEDMTFAEEFVAEAGNLMGGLDMLI----LNHV---LYNRLTFFHGEID---NVRKSM 117 Query: 123 QQYNVSKFVFSSSAT--VYGDATRFPNMIPIPEECPLGPT-NPYGHTKYAIENILNDLYN 179 + N FV S A + + ++ P PY +K+A++ + L + Sbjct: 118 -EVNFHSFVVLSVAAMPMLMQSQGSIAVVSSVAGKITYPLIAPYSASKFALDGFFSTLRS 176 >6CGE-A nrPDB Length = 328 Score = 41.7 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 34/175 (19%), Positives = 64/175 (36%), Gaps = 31/175 (17%) Query: 13 IVLVTGGAGYIGSHTVVELIENGYDCVVA-----DNLSNSTYDSVARLEVLTKHHIPFYE 67 +VL+TG + IG H V L + D + AR + + Sbjct: 5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQ 64 Query: 68 VDLCDRKGL---EKVFKEYKIDSVIHFAGLKAVGESTQIPLRYY----HNNILGTVVLLE 120 +D+ D K + + E ++D ++ AGL +G + N++GTV +L+ Sbjct: 65 LDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQ 124 Query: 121 L----MQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIE 171 M++ + + + S G P + Y +K+A+E Sbjct: 125 AFLPDMKRRGSGRVLVTGSV---GGLMGLP------------FNDVYCASKFALE 164 >1A27-A nrPDB Length = 289 Score = 41.7 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 34/175 (19%), Positives = 64/175 (36%), Gaps = 31/175 (17%) Query: 13 IVLVTGGAGYIGSHTVVELIENGYDCVVA-----DNLSNSTYDSVARLEVLTKHHIPFYE 67 +VL+TG + IG H V L + D + AR + + Sbjct: 4 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQ 63 Query: 68 VDLCDRKGL---EKVFKEYKIDSVIHFAGLKAVGESTQIPLRYY----HNNILGTVVLLE 120 +D+ D K + + E ++D ++ AGL +G + N++GTV +L+ Sbjct: 64 LDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQ 123 Query: 121 L----MQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIE 171 M++ + + + S G P + Y +K+A+E Sbjct: 124 AFLPDMKRRGSGRVLVTGSV---GGLMGLP------------FNDVYCASKFALE 163 >5OVJ-A nrPDB Length = 256 Score = 41.7 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 25/138 (18%), Positives = 48/138 (34%), Gaps = 25/138 (18%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 S+ VLVTGG IG L +G+ V + + D+ Sbjct: 24 SRSVLVTGGNRGIGLAIARRLAADGHKVAV------------THRGSGAPDDLFGVQCDV 71 Query: 71 CDRKGLEKVFKE-----YKIDSVIHFAGLK----AVGESTQIPLRYYHNNILGTVVLLE- 120 D +++ FKE ++ ++ AG+ + + + + N+ G + Sbjct: 72 TDSAAVDRAFKEVEEHQGPVEVLVANAGISKDAFLMRMTEERFEEVINTNLTGAFRCAQR 131 Query: 121 ---LMQQYNVSKFVFSSS 135 MQ+ + +F S Sbjct: 132 ASRTMQRKRFGRIIFIGS 149 >5YSS-A nrPDB Length = 256 Score = 41.7 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 26/139 (18%), Positives = 50/139 (35%), Gaps = 16/139 (11%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 T K LVTG IG L + G ++ D+ ++ D Sbjct: 4 TGKTALVTGSTSGIGLGIAQVLAQAGATLILNGF---GDVDAAKDAVAQYGKTPGYHGAD 60 Query: 70 LCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGESTQIPLRYYH-------NNILGTVV 117 L D + + + +D +I+ AG++ V P+ ++ +++ T Sbjct: 61 LSDEAQIADMMRYAESEFGGVDILINNAGIQHVSPIETFPVDKWNAIIAINLSSVFHTTR 120 Query: 118 L-LELMQQYNVSKFVFSSS 135 L L M+ N + + +S Sbjct: 121 LALPGMRARNWGRIINIAS 139 >3EZL-A nrPDB Length = 256 Score = 41.7 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 24/139 (17%), Positives = 51/139 (36%), Gaps = 13/139 (9%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 + +I VTGG G IG+ L ++G+ V ++ + E + Sbjct: 12 SQRIAYVTGGMGGIGTSICQRLHKDGFRVVAGCGPNSPRRVKWLEDQKALGFDFYASEGN 71 Query: 70 LCDRKGLEKVFKEYK-----IDSVIHFAG----LKAVGESTQIPLRYYHNNILG----TV 116 + D ++ F + K ID +++ AG + + + N+ T Sbjct: 72 VGDWDSTKQAFDKVKAEVGEIDVLVNNAGITRDVVFRKMTREDWQAVIDTNLTSLFNVTK 131 Query: 117 VLLELMQQYNVSKFVFSSS 135 +++ M + + + SS Sbjct: 132 QVIDGMVERGWGRIINISS 150 >5IZ4-A nrPDB Length = 271 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 30/151 (19%), Positives = 57/151 (37%), Gaps = 24/151 (15%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHH---IP 64 +S++ + ++TG A IG+ T + + G+ V N +ST D+ + +E L + Sbjct: 11 QSSTPVCVITGSASGIGAATALRFAQAGWS-VAIGNFDDSTRDAASTVEALCRDAGAQTL 69 Query: 65 FYEVDLCDRKGLEKVFKEY-----KIDSVIHFAGLKAV--GESTQIPLRY-----YHNNI 112 ++ D+ +ID++I+ AG V + + Y N+ Sbjct: 70 IFDADVGKDADCRHAVDMVASRWQRIDALINCAGTTRVIPHNAFDQIDDFEFERVYRVNL 129 Query: 113 LGTVV--------LLELMQQYNVSKFVFSSS 135 +G L E + V SS Sbjct: 130 IGLYQMTRAAVPLLRESASATRSTSVVNVSS 160 >3OSU-A nrPDB Length = 246 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 26/141 (18%), Positives = 50/141 (35%), Gaps = 13/141 (9%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYE 67 +K LVTG + IG ++L E GY+ V S ++V + Sbjct: 1 MKMTKSALVTGASRGIGRSIALQLAEEGYNVAVNYAGSKEKAEAVVEEIKAKGVDSFAIQ 60 Query: 68 VDLCDRKGLEKVFKE-----YKIDSVIHFAGLK----AVGESTQIPLRYYHNNILGTVVL 118 ++ D ++ + KE +D +++ AG+ + Q N+ G Sbjct: 61 ANVADADEVKAMIKEVVSQFGSLDVLVNNAGITRDNLLMRMKEQEWDDVIDTNLKGVFNC 120 Query: 119 LE----LMQQYNVSKFVFSSS 135 ++ M + + SS Sbjct: 121 IQKATPQMLRQRSGAIINLSS 141 >4NBT-A nrPDB Length = 240 Score = 41.3 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 44/253 (17%), Positives = 86/253 (33%), Gaps = 43/253 (16%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYE 67 + K+ ++TGGA +G + E G + D L + TY ++ Sbjct: 3 KLEGKVAVITGGAKGLGQAIALAYAEEGAKVIAGD-LGDLTYS---------HPNVEGMY 52 Query: 68 VDLCDRKGLEKVFKE-----YKIDSVIHFAG--LKAVGESTQIP--LRYYHNNILGTVVL 118 +++ D G+EK ++ KID +++ AG A+ N+ G L Sbjct: 53 LNVTDVTGVEKFYQSVIDKYGKIDILVNNAGITKDAMTRKMTEAQWDAVIDVNLKGVFNL 112 Query: 119 LE----LMQQYNVSKFVFSSS-ATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENI 173 MQ + SS V+G+ + Y TK + I Sbjct: 113 TRLVGPQMQTNGYGSIINISSVVGVFGNIGQAN----------------YAATKAGV--I 154 Query: 174 LNDLYNSDKKSWKFAILRYFNPI-GAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYI 232 + + + + K A +R G + ++ P + + +G+ E++ Sbjct: 155 GLTMTWAKEFALKGANVRVNAIAPGYIMTDILKTVPQDLLDKFAALTMLNRLGQPEEIAK 214 Query: 233 FGDDYDSRDGTPI 245 S D + + Sbjct: 215 VALFLASDDASYV 227 >2EW8-A nrPDB Length = 249 Score = 41.3 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 25/152 (16%), Positives = 58/152 (38%), Gaps = 21/152 (13%) Query: 1 MTAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTK 60 MT +L+ K+ ++TGGA IG G D +AD + ++ R Sbjct: 1 MTQRLKD----KLAVITGGANGIGRAIAERFAVEGADIAIADLVPAPEAEAAIRN---LG 53 Query: 61 HHIPFYEVDLCDRKGLEKVFKE-----YKIDSVIHFAGLK----AVGESTQIPLRYYHNN 111 + + D+ +E K+ + D +++ AG+ + + + + N Sbjct: 54 RRVLTVKCDVSQPGDVEAFGKQVISTFGRCDILVNNAGIYPLIPFDELTFEQWKKTFEIN 113 Query: 112 ILGTVVLLEL----MQQYNVSKFVFSSSATVY 139 + ++ + M++ + + ++T Y Sbjct: 114 VDSGFLMAKAFVPGMKRNGWGRIINL-TSTTY 144 >5PGZ-A nrPDB Length = 276 Score = 41.0 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 34/176 (19%), Positives = 62/176 (35%), Gaps = 11/176 (6%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYE 67 K V+VTG + IG L + G V+ V+R L + Sbjct: 15 MLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIA 74 Query: 68 VDLCDRKGLEKVF-KEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN 126 + D E+ K K+ + L + TQ L +H++I ++E+ N Sbjct: 75 GTMEDMTFAEQFIVKAGKLMGGLDMLILNHI---TQTSLSLFHDDIHSVRRVMEV----N 127 Query: 127 VSKFVFSSSAT--VYGDATRFPNMIPIPEECPLGPT-NPYGHTKYAIENILNDLYN 179 +V S+A + + +I P PY +K+A++ + + Sbjct: 128 FLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRT 183 >2Q2Q-A nrPDB Length = 255 Score = 41.0 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 33/140 (23%), Positives = 53/140 (37%), Gaps = 20/140 (14%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYE--V 68 K LVTG IG L G + V+ N D L + +H + Sbjct: 4 GKTALVTGSTSGIGLGIAQVLARAGANIVL-----NGFGDPAPALAEIARHGVKAVHHPA 58 Query: 69 DLCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGESTQIPLRYYHN----NIL----GT 115 DL D +E +F +D +++ AG++ V Q PL + N+ GT Sbjct: 59 DLSDVAQIEALFALAEREFGGVDILVNNAGIQHVAPVEQFPLESWDKIIALNLSAVFHGT 118 Query: 116 VVLLELMQQYNVSKFVFSSS 135 + L M+ N + + +S Sbjct: 119 RLALPGMRARNWGRIINIAS 138 >4JRO-A nrPDB Length = 271 Score = 41.0 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 27/152 (17%), Positives = 58/152 (38%), Gaps = 18/152 (11%) Query: 2 TAQLQSEST-----SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLE 56 T L +S K+ +VTGG+ IG + L + G + N S + A+L Sbjct: 15 TENLYFQSNAMTLQGKVAVVTGGSRGIGRDIAINLAKEGANIFFNYNGSPEAAEETAKLV 74 Query: 57 VLTKHHIPFYEVDLCDRKGLEKVFKE-----YKIDSVIHFAGLK----AVGESTQIPLRY 107 + + ++ + ++ FK+ ++D +++ AG+ + Sbjct: 75 AEHGVEVEAMKANVAIAEDVDAFFKQAIERFGRVDILVNNAGITRDNLLMRMKEDEWDDV 134 Query: 108 YHNNILGTVVLLEL----MQQYNVSKFVFSSS 135 + N+ GT + + M + K + +S Sbjct: 135 ININLKGTFLCTKAVSRTMMKQRAGKIINMAS 166 >3ZV3-A nrPDB Length = 281 Score = 40.2 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 36/186 (19%), Positives = 68/186 (36%), Gaps = 36/186 (19%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYE 67 + T ++ L+TGGA +G V + G V D + + + LEV + Sbjct: 2 KLTGEVALITGGASGLGRALVDRFVAEGARVAVLDK----SAERLRELEVAHGGNAVGVV 57 Query: 68 VDLCDRKGLEKVFKE-----YKIDSVIHFAG----LKAVGESTQIPLRY-----YHNNIL 113 D+ + ++ + KID++I AG A+ + + + +H N+ Sbjct: 58 GDVRSLQDQKRAAERCLAAFGKIDTLIPNAGIWDYSTALADLPEDKIDAAFDDIFHVNVK 117 Query: 114 GTVVLLELMQQYNVS---KFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAI 170 G + ++ VS VF+ S + P G Y TK+A+ Sbjct: 118 GYIHAVKACLPALVSSRGSVVFTISNAGFY---------------PNGGGPLYTATKHAV 162 Query: 171 ENILND 176 ++ Sbjct: 163 VGLVRQ 168 >3EMK-A nrPDB Length = 246 Score = 40.2 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 22/121 (18%), Positives = 43/121 (35%), Gaps = 13/121 (10%) Query: 7 SESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFY 66 + T + LVTG G +G L G L + + + L I + Sbjct: 3 FDLTGRKALVTGATGGLGEAIARALHAQGA----IVGLHGTREEKLKELAAELGERIFVF 58 Query: 67 EVDLCDRKGLEKVFKE-----YKIDSVIHFAGLK----AVGESTQIPLRYYHNNILGTVV 117 +L DR+ ++ + ++ +D +++ AG+ V S + N+ Sbjct: 59 PANLSDREAVKALGQKAEEEMGGVDILVNNAGITRDGLFVRMSDEDWDAVLTVNLTSVFN 118 Query: 118 L 118 L Sbjct: 119 L 119 >4IS3-A nrPDB Length = 268 Score = 40.2 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 27/160 (16%), Positives = 59/160 (36%), Gaps = 19/160 (11%) Query: 3 AQLQSESTS----KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVL 58 L + + K+ ++TGG IG I+NG + ++A+L+ L Sbjct: 13 ENLYFQGMNLVQDKVTIITGGTRGIGFAAAKIFIDNGAKVSIFGETQEEVDTALAQLKEL 72 Query: 59 T-KHHIPFYEVDLCDRKGLEKVFKE-----YKIDSVIHFAGLKAV----GESTQIPLRYY 108 + + + DL R + + ++D +I+ AG+ + S + Sbjct: 73 YPEEEVLGFAPDLTSRDAVMAAVGQVAQKYGRLDVMINNAGITSNNVFSRVSEEEFKHIM 132 Query: 109 HNNILGTVV----LLELMQQYNVSKFVFSSSAT-VYGDAT 143 N+ G + M+ + ++S T ++G + Sbjct: 133 DINVTGVFNGAWCAYQCMKDAKKGVIINTASVTGIFGSLS 172 >4BO1-A nrPDB Length = 269 Score = 39.8 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 29/141 (20%), Positives = 50/141 (35%), Gaps = 18/141 (12%) Query: 2 TAQLQSESTS---KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVL 58 T L +S S K+ LVTG + IG +EL G V+ S S + +A Sbjct: 15 TENLYFQSMSLQGKVALVTGASRGIGQAIALELGRLG-AVVIGTATSASGAEKIAETLKA 73 Query: 59 TKHHIPFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVL 118 +D+ + + A L+ + + PL +N + L Sbjct: 74 NGVEGAGLVLDVSSDESVA--------------ATLEHIQQHLGQPLIVVNNAGITRDNL 119 Query: 119 LELMQQYNVSKFVFSSSATVY 139 L M+ V ++ ++Y Sbjct: 120 LVRMKDDEWFDVVNTNLNSLY 140 >1OOE-A nrPDB Length = 236 Score = 39.4 bits (90), Expect = 0.006, Method: Composition-based stats. Identities = 21/84 (25%), Positives = 36/84 (42%), Gaps = 4/84 (4%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 +S V+V GG G +GS + +NGY + D +N DS + V + E Sbjct: 2 SSGKVIVYGGKGALGSAILEFFKKNGYTVLNIDLSANDQADS--NILVDGNKNWTEQEQS 59 Query: 70 LCDRKGLEKVFKEYKIDSVIHFAG 93 + ++ + ++D V AG Sbjct: 60 ILEQT--ASSLQGSQVDGVFCVAG 81 >5LCX-A nrPDB Length = 316 Score = 39.0 bits (89), Expect = 0.008, Method: Composition-based stats. Identities = 24/96 (25%), Positives = 43/96 (44%), Gaps = 12/96 (12%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVL-----TKHHIPFY 66 + LVTG IG +L E G +V N AR ++L +++ + F+ Sbjct: 8 RYALVTGANKGIGFEICRQLAEKG--IIVILTSRNEKRGLEARQKLLKELNVSENRLVFH 65 Query: 67 EVDLCDRKGLEKVF-----KEYKIDSVIHFAGLKAV 97 ++D+ D + V K K+D +++ AG+ V Sbjct: 66 QLDVTDLASVAAVAVFIKSKFGKLDILVNNAGVSGV 101 >4KMS-A nrPDB Length = 249 Score = 38.6 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 43/235 (18%), Positives = 80/235 (34%), Gaps = 37/235 (15%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 S+I +VTGG IG T +EL G V N S YD+ +E + + Sbjct: 9 MSEIAIVTGGTRGIGKATALELKNKGLTVVA--NFF-SNYDAAKEMEEKYGIKTKCW--N 63 Query: 70 LCDRKGLEKVFKEY------KIDSVIHFAG----LKAVGESTQIPLRYYHNNILGTVV-- 117 + D + + KE + +++ AG S Q + N+ Sbjct: 64 VADFEECRQAVKEIEEEFKKPVSILVNNAGITKDKMLHRMSHQDWNDVINVNLNSCFNMS 123 Query: 118 --LLELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILN 175 ++E M+ + + V SS N Y K I Sbjct: 124 SSVMEQMRNQDYGRIVNISSINAQAGQVGQTN---------------YSAAKAGIIGFTK 168 Query: 176 DLYNSDKKSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKL 230 L + + + K + P G + ++G P + ++ + + +G+ E++ Sbjct: 169 AL--ARETASKNITVNCIAP-GYIATEMVGAVPEDVLAKIINSIPKKRLGQPEEI 220 >5F5N-A nrPDB Length = 289 Score = 38.6 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 18/74 (24%), Positives = 26/74 (35%), Gaps = 5/74 (6%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 ++ +LVTG G G TV L+ G V A T + A + DL Sbjct: 1 NRTILVTGATGTQGGATVRALLARG-RPVRALVRDPGTDAARALAAAG----VSLVTGDL 55 Query: 71 CDRKGLEKVFKEYK 84 D+ L + Sbjct: 56 NDQASLRAAMADVH 69 >4RGB-A nrPDB Length = 294 Score = 38.6 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 39/193 (20%), Positives = 68/193 (35%), Gaps = 38/193 (19%) Query: 11 SKIVLVTGGA-GYIGSHTVVELIENGYDCVVADNLSN--------STYDSV---ARLEVL 58 ++V +TG A G SH V E G + V D + TY+ + ARL Sbjct: 25 GRVVFITGAARGQGRSH-AVMCAEQGANIVGVDICEDIDIVPYKLGTYEELEETARLVEK 83 Query: 59 TKHHIPFYEVDLCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGESTQIPLRY----YH 109 T + F + D+ D+ L++VF ID+VI AG+ + Sbjct: 84 TGQEMLFRKADVRDKAVLQEVFDAGVEQFGHIDTVIANAGVVLTNPDERDASEALRLGLD 143 Query: 110 NNILGTVVLLELMQQY-----NVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYG 164 ++G ++ + + +SS + + G T+ Y Sbjct: 144 IMLIGVWNTFQVAIPHMKERGQGGNLIATSS-----------MIALLDLTDGRGGTDAYL 192 Query: 165 HTKYAIENILNDL 177 +K AI ++ Sbjct: 193 TSKLAITGLVRSY 205 >2Q4B-A nrPDB Length = 253 Score = 38.6 bits (88), Expect = 0.009, Method: Composition-based stats. Identities = 35/192 (18%), Positives = 60/192 (31%), Gaps = 37/192 (19%) Query: 13 IVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCD 72 VLVTG +G G +L E G D VA L S + + D+ D Sbjct: 6 TVLVTGASGRTGQIVYKKLKE-GSDKFVAKGLVRSAQG-----KEKIGGEADVFIGDITD 59 Query: 73 RKGLEKVFKEYKIDS-VIHFAGLKAVGESTQ-----IPLRYYHN-------NILGTVVLL 119 + F+ ID+ VI + + + P + + + +G + Sbjct: 60 ADSINPAFQ--GIDALVILTSAVPKMKPGFDPTKGGRPEFIFEDGQYPEQVDWIGQKNQI 117 Query: 120 ELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYN 179 + + V V S + P P N G+ + + Y Sbjct: 118 DAAKVAGVKHIVVVGS---------------MGGTNPDHPLNKLGNGNILVWKRKAEQYL 162 Query: 180 SDKKSWKFAILR 191 +D + I+R Sbjct: 163 AD-SGTPYTIIR 173 >1HE4-A nrPDB Length = 206 Score = 38.6 bits (88), Expect = 0.010, Method: Composition-based stats. Identities = 27/135 (20%), Positives = 47/135 (34%), Gaps = 16/135 (11%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLC 71 K + + G G G T+ + ++ GY+ V +RL D+ Sbjct: 4 KKIAIFGATGQTGLTTLAQAVQAGYEVTVLVR-------DSSRLPSEGPRPAHVVVGDVL 56 Query: 72 DRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFV 131 ++K D+VI G + P G ++ M+ + V K V Sbjct: 57 QAADVDKTVA--GQDAVIVLLGT----RNDLSPTTVMSE---GARNIVAAMKAHGVDKVV 107 Query: 132 FSSSATVYGDATRFP 146 +SA + D T+ P Sbjct: 108 ACTSAFLLWDPTKVP 122 >2O23-A nrPDB Length = 265 Score = 38.6 bits (88), Expect = 0.010, Method: Composition-based stats. Identities = 23/125 (18%), Positives = 49/125 (39%), Gaps = 19/125 (15%) Query: 13 IVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCD 72 + ++TGGA +G T L+ G V+ D ++ +L ++ F D+ Sbjct: 14 VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL----GNNCVFAPADVTS 69 Query: 73 RKGLEKVFKEYK-----IDSVIHFAGLKAVGEST----------QIPLRYYHNNILGTVV 117 K ++ K +D ++ AG+ ++ + R N++GT Sbjct: 70 EKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFN 129 Query: 118 LLELM 122 ++ L+ Sbjct: 130 VIRLV 134 >2HRB-A nrPDB Length = 274 Score = 38.3 bits (87), Expect = 0.013, Method: Composition-based stats. Identities = 32/202 (15%), Positives = 62/202 (30%), Gaps = 47/202 (23%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 S++ LVTG IG EL VV + + + F+++D+ Sbjct: 2 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 61 Query: 71 CDRKGLEKVFKEYKIDS-----VIHFAGLKAVGESTQIPLRY-------YHNNILGTVV- 117 D + + + + + +++ A V + P+ + N T Sbjct: 62 DDLQSIRALRDFLRKEYGGLNVLVNNAA---VAFKSDDPMPFDIKAEMTLKTNFFATRNM 118 Query: 118 ---LLELMQQYNVSKFVFSSS-------------------ATVYGDATRFPNMIPIPEEC 155 LL +M+ + + V SS + + M E+ Sbjct: 119 CNELLPIMKPHG--RVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 176 Query: 156 PLG-------PTNPYGHTKYAI 170 P +PYG +K + Sbjct: 177 KNEVHEREGWPNSPYGVSKLGV 198 >3RKU-A nrPDB Length = 287 Score = 37.5 bits (85), Expect = 0.020, Method: Composition-based stats. Identities = 26/175 (14%), Positives = 62/175 (35%), Gaps = 27/175 (15%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIP-----F 65 K VL+TG + IG T +E +E + L+ + + L+ P Sbjct: 33 KKTVLITGASAGIGKATALEYLEASNGDMKL-ILAARRLEKLEELKKTIDQEFPNAKVHV 91 Query: 66 YEVDLCDRKGLEKVFKEY-----KIDSVIHFAGLKAVGE-----STQIPLRYYHNNILGT 115 ++D+ + ++ + ID +++ AG + +T+ + N+ Sbjct: 92 AQLDITQAEKIKPFIENLPQEFKDIDILVNNAGKALGSDRVGQIATEDIQDVFDTNVTAL 151 Query: 116 VVLLELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAI 170 + + + V + ++ GD ++ + Y +K+A+ Sbjct: 152 INITQA-----VLPIFQAKNS---GDIVNLGSIAG---RDAYPTGSIYCASKFAV 195 >2B4Q-A nrPDB Length = 276 Score = 37.5 bits (85), Expect = 0.020, Method: Composition-based stats. Identities = 29/187 (15%), Positives = 53/187 (28%), Gaps = 33/187 (17%) Query: 6 QSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPF 65 +I LVTGG+ IG L+E G + + + D+ RL Sbjct: 24 YFSLAGRIALVTGGSRGIGQMIAQGLLEAGARVFICARDAEACADTATRLSAYGDCQA-- 81 Query: 66 YEVDLCDRKGLEKVFK-----EYKIDSVIHFAGLKAVGESTQIPLRYYHN----NILGTV 116 DL G ++ + ++D +++ AG P+ + N+ Sbjct: 82 IPADLSSEAGARRLAQALGELSARLDILVNNAGTSWGAALESYPVSGWEKVMQLNVTSVF 141 Query: 117 V--------LLELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKY 168 L N ++ + S YG +K Sbjct: 142 SCIQQLLPLLRRSASAENPARVINIGSVAGISAMGEQAYA--------------YGPSKA 187 Query: 169 AIENILN 175 A+ + Sbjct: 188 ALHQLSR 194 >3GRP-A nrPDB Length = 266 Score = 37.5 bits (85), Expect = 0.021, Method: Composition-based stats. Identities = 26/142 (18%), Positives = 49/142 (34%), Gaps = 17/142 (11%) Query: 7 SESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFY 66 + T + LVTG G IG G L + D + + + + Sbjct: 23 FKLTGRKALVTGATGGIGEAIARCFHAQGA----IVGLHGTREDKLKEIAADLGKDVFVF 78 Query: 67 EVDLCDRKGLEKVFKE-----YKIDSVIHFAGLK----AVGESTQIPLRYYHNNILG--- 114 +L DRK ++++ + ID +++ AG+ V Q N+ Sbjct: 79 SANLSDRKSIKQLAEVAEREMEGIDILVNNAGITRDGLFVRMQDQDWDDVLAVNLTAAST 138 Query: 115 -TVVLLELMQQYNVSKFVFSSS 135 T L+ M + + + +S Sbjct: 139 LTRELIHSMMRRRYGRIINITS 160 >2GAS-A nrPDB Length = 307 Score = 37.5 bits (85), Expect = 0.022, Method: Composition-based stats. Identities = 22/93 (23%), Positives = 39/93 (41%), Gaps = 5/93 (5%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHH---IPFY 66 T +L+ G G IG H V I+ G + + + + E++ + + Sbjct: 1 TENKILILGPTGAIGRHIVWASIKAGNPTYALVRKTITAANPETKEELIDNYQSLGVILL 60 Query: 67 EVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGE 99 E D+ D + L K K ++D VI AG + + Sbjct: 61 EGDINDHETLVKAIK--QVDIVICAAGRLLIED 91 >3RSH-A nrPDB Length = 251 Score = 37.5 bits (85), Expect = 0.022, Method: Composition-based stats. Identities = 21/139 (15%), Positives = 46/139 (33%), Gaps = 17/139 (12%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 K+ LVTG + IG L E G + + ++ + + ++ Sbjct: 11 EGKVALVTGASRGIGKAIAELLAERGAKVIG----TATSESGAQAISDYLGDNGKGMALN 66 Query: 70 LCDRKGLEKVFKE-----YKIDSVIHFAGLK----AVGESTQIPLRYYHNNILGTVVL-- 118 + + + +E V K +D +++ AG+ + + N+ L Sbjct: 67 VTNPESIEAVLKAITDEFGGVDILVNNAGITRDNLLMRMKEEEWSDIMETNLTSIFRLSK 126 Query: 119 --LELMQQYNVSKFVFSSS 135 L M + + + S Sbjct: 127 AVLRGMMKKRQGRIINVGS 145 >3F9I-A nrPDB Length = 249 Score = 37.1 bits (84), Expect = 0.023, Method: Composition-based stats. Identities = 15/75 (20%), Positives = 30/75 (40%), Gaps = 4/75 (5%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYE 67 + T K L+TG + IGS L + G ++ S S + + L K + Sbjct: 11 DLTGKTSLITGASSGIGSAIARLLHKLGSKVII----SGSNEEKLKSLGNALKDNYTIEV 66 Query: 68 VDLCDRKGLEKVFKE 82 +L +++ + + Sbjct: 67 CNLANKEECSNLISK 81 >4CR6-A nrPDB Length = 271 Score = 37.1 bits (84), Expect = 0.028, Method: Composition-based stats. Identities = 25/114 (21%), Positives = 39/114 (34%), Gaps = 12/114 (10%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVAD---NLSNSTYDSVARLEVLTKHHIPFYE 67 K +VTG AG IG TV + G V D L+ + Y+ + + Sbjct: 15 GKAAIVTGAAGGIGRATVEAYLREGASVVAMDLAPRLAATRYEEPGAIPIACDLADRAAI 74 Query: 68 VDLCDRKGLEKVFKEYKIDSVIHFAGLKA-----VGESTQIPLRYYHNNILGTV 116 + V + +D ++ LK + S RY N+ GT Sbjct: 75 D----AAMADAVARLGGLDILVAGGALKGGTGNFLDLSDADWDRYVDVNMTGTF 124 >1H5Q-A nrPDB Length = 265 Score = 36.7 bits (83), Expect = 0.032, Method: Composition-based stats. Identities = 32/190 (16%), Positives = 61/190 (32%), Gaps = 16/190 (8%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 +K ++VTGG IG + G + V + + ++ Y+ D+ Sbjct: 14 NKTIIVTGGNRGIGLAFTRAVAAAGANVAVIYRSAADAVEVTEKVGKEFGVKTKAYQCDV 73 Query: 71 CDRKGLEKVFKEYKID-----SVIHFAGLKAVGESTQIPLRY----YHNNILGTVVLLEL 121 + + K ++ D +I AG+ V +T++ Y N+ G Sbjct: 74 SNTDIVTKTIQQIDADLGPISGLIANAGVSVVKPATELTHEDFAFVYDVNVFGVFNTCRA 133 Query: 122 MQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSD 181 + + + K S V + Y +K A N++ L Sbjct: 134 VAKLWLQK-QQKGSIVVTSSMSSQIINQSSLNGSLTQVF--YNSSKAACSNLVKGL---- 186 Query: 182 KKSWKFAILR 191 W A +R Sbjct: 187 AAEWASAGIR 196 >2C07-A nrPDB Length = 285 Score = 36.7 bits (83), Expect = 0.032, Method: Composition-based stats. Identities = 25/146 (17%), Positives = 53/146 (36%), Gaps = 14/146 (9%) Query: 3 AQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHH 62 +K+ LVTG IG ++ V+ + + + DSV + Sbjct: 36 ENYYYCGENKVALVTGAGRGIGREIAK-MLAKSVSHVICISRTQKSCDSVVDEIKSFGYE 94 Query: 63 IPFYEVDLCDRKGLEKVFKEY-----KIDSVIHFAG-------LKAVGESTQIPLRYYHN 110 Y D+ ++ + +V + +D +++ AG L+ + + LR N Sbjct: 95 SSGYAGDVSKKEEISEVINKILTEHKNVDILVNNAGITRDNLFLRMKNDEWEDVLRTNLN 154 Query: 111 NIL-GTVVLLELMQQYNVSKFVFSSS 135 ++ T + + M + + SS Sbjct: 155 SLFYITQPISKRMINNRYGRIINISS 180 >2VO1-A nrPDB Length = 295 Score = 36.7 bits (83), Expect = 0.036, Method: Composition-based stats. Identities = 21/89 (23%), Positives = 31/89 (34%), Gaps = 12/89 (13%) Query: 2 TAQLQSESTSKIVLVTGGA------GYIGSHTVVELIENGYDC--VVAD---NLSNSTYD 50 T L +S K +LVTGG G I S L G + D N+ T+ Sbjct: 15 TENLYFQSM-KYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFS 73 Query: 51 SVARLEVLTKHHIPFYEVDLCDRKGLEKV 79 EV ++DL + + + Sbjct: 74 PYEHGEVFVLDDGGEVDLDLGNYERFLDI 102 >1AHH-A nrPDB Length = 255 Score = 36.7 bits (83), Expect = 0.036, Method: Composition-based stats. Identities = 22/121 (18%), Positives = 44/121 (36%), Gaps = 11/121 (9%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 K ++TG IG + G VV+D +++ V ++ L D+ Sbjct: 11 GKCAIITGAGAGIGKEIAITFATAGASVVVSDINADAANHVVDEIQQLGGQAFA-CRCDI 69 Query: 71 CDRKGLEKVFK-----EYKIDSVIHFAGLKAVGESTQIPLRY----YHNNILGTVVLLEL 121 + L + K+D +++ AG + +P+ Y N+ L +L Sbjct: 70 TSEQELSALADFAISKLGKVDILVNNAGGGG-PKPFDMPMADFRRAYELNVFSFFHLSQL 128 Query: 122 M 122 + Sbjct: 129 V 129 >4FC7-A nrPDB Length = 277 Score = 36.7 bits (83), Expect = 0.037, Method: Composition-based stats. Identities = 25/126 (19%), Positives = 49/126 (38%), Gaps = 10/126 (7%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLC 71 K+ +TGG IG + +G V+A + +L T +D+ Sbjct: 28 KVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSMDVR 87 Query: 72 D----RKGLEKVFKEY-KIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYN 126 +++ KE+ +ID +I+ A + P N TV+ ++ +N Sbjct: 88 APPAVMAAVDQALKEFGRIDILINCAA-----GNFLCPAGALSFNAFKTVMDIDTSGTFN 142 Query: 127 VSKFVF 132 VS+ ++ Sbjct: 143 VSRVLY 148 >2X9N-A nrPDB Length = 288 Score = 36.7 bits (83), Expect = 0.037, Method: Composition-based stats. Identities = 24/132 (18%), Positives = 45/132 (34%), Gaps = 10/132 (7%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVAD-NLSNSTYDSVARLEVLTKHHIPFYEVDLCD 72 +VTG A IG V+L + GY V+ N + + L + + DL + Sbjct: 26 AVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVCQADLTN 85 Query: 73 R----KGLEKVFKE-----YKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQ 123 E++ + D +++ A Q N + EL+ Sbjct: 86 SNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTPLVQGDHEDNSNGKTVETQVAELIG 145 Query: 124 QYNVSKFVFSSS 135 ++ F+ + S Sbjct: 146 TNAIAPFLLTMS 157 >3OEC-A nrPDB Length = 317 Score = 35.9 bits (81), Expect = 0.057, Method: Composition-based stats. Identities = 31/153 (20%), Positives = 49/153 (32%), Gaps = 25/153 (16%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVAD------NLSNSTYDS-----VARLE 56 K+ +TG A G V L ++G D V D NL + RL Sbjct: 43 RLQGKVAFITGAARGQGRTHAVRLAQDGADIVAIDLCRQQPNLDYAQGSPEELKETVRLV 102 Query: 57 VLTKHHIPFYEVDLCDRKGLEKVFKE-----YKIDSVIHFAGLKA----VGESTQIPLRY 107 I + D+ D L+ V E ID ++ G+ V + Q Sbjct: 103 EEQGRRIIARQADVRDLASLQAVVDEALAEFGHIDILVSNVGISNQGEVVSLTDQQWSDI 162 Query: 108 YHNNILGTVVLLELMQQYNVSK-----FVFSSS 135 N++G + + + +F SS Sbjct: 163 LQTNLIGAWHACRAVLPSMIERGQGGSVIFVSS 195 >2BC1-A nrPDB Length = 490 Score = 35.9 bits (81), Expect = 0.057, Method: Composition-based stats. Identities = 23/101 (22%), Positives = 32/101 (31%), Gaps = 22/101 (21%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLC 71 K V V G AGYIG G + V+ D + +Y+ DL Sbjct: 195 KRVAVVG-AGYIGVELAEAFQRKGKEVVLIDVVDT--------------CLAGYYDRDLT 239 Query: 72 DRKGLEKVFKEYKIDSVI-----HFAGLKAVGESTQIPLRY 107 D + K +E+ I AG V + Y Sbjct: 240 D--LMAKNMEEHGIQLAFGETVKEVAGNGKVEKIITDKNEY 278 >3ORF-A nrPDB Length = 251 Score = 35.9 bits (81), Expect = 0.065, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 23/55 (41%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIP 64 SK +LV GG+G +G+ V ++ + D N D ++ + I Sbjct: 21 MSKNILVLGGSGALGAEVVKFFKSKSWNTISIDFRENPNADHSFTIKDSGEEEIK 75 >3UVE-A nrPDB Length = 286 Score = 35.6 bits (80), Expect = 0.072, Method: Composition-based stats. Identities = 32/131 (24%), Positives = 48/131 (36%), Gaps = 27/131 (20%) Query: 10 TSKIVLVTGGA-GYIGSHTVVELIENGYDCVVADN------------LSNSTYDSVARLE 56 K+ VTG A G SH V L + G D + D + ST + +A Sbjct: 10 EGKVAFVTGAARGQGRSHAVR-LAQEGADIIAVDICKPIRAGVVDTAIPASTPEDLAETA 68 Query: 57 VLTKHH---IPFYEVDLCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGE-----STQI 103 L K H I EVD+ D L+ ++D ++ AG+ G+ S + Sbjct: 69 DLVKGHNRRIVTAEVDVRDYDALKAAVDSGVEQLGRLDIIVANAGIGNGGDTLDKTSEED 128 Query: 104 PLRYYHNNILG 114 N+ G Sbjct: 129 WTEMIDINLAG 139 >1AE1-A nrPDB Length = 273 Score = 35.6 bits (80), Expect = 0.075, Method: Composition-based stats. Identities = 34/185 (18%), Positives = 61/185 (32%), Gaps = 38/185 (20%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 LVTGG+ IG V EL G S + + LE+ + + E + Sbjct: 21 GTTALVTGGSKGIGYAIVEELAGLGARVY---TCSRNEKELDECLEIWREKGLN-VEGSV 76 Query: 71 CDR----------KGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYH----NNILGTV 116 CD + + VF + K++ +++ AG+ E+ + Y+ N Sbjct: 77 CDLLSRTERDKLMQTVAHVF-DGKLNILVNNAGVVIHKEAKDFTEKDYNIIMGTNFEAAY 135 Query: 117 VLLELM----QQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIEN 172 L ++ + +F SS + + Y +K AI Sbjct: 136 HLSQIAYPLLKASQNGNVIFLSSIAGFSALPSV---------------SLYSASKGAINQ 180 Query: 173 ILNDL 177 + L Sbjct: 181 MTKSL 185 >5B1Y-A nrPDB Length = 270 Score = 35.6 bits (80), Expect = 0.077, Method: Composition-based stats. Identities = 25/138 (18%), Positives = 53/138 (38%), Gaps = 14/138 (10%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVAD-NLSNSTYDSVARLEVLTKHHIPFYEVDLCD 72 LVTGG+ IG TV+ G+ V+A + ++ + L VD+ D Sbjct: 26 ALVTGGSRGIGRATVLRFAREGWSVVIAYKSRADLAEKTAEEARRLGSPEAYTVRVDVGD 85 Query: 73 RKGLEKVFKEY-----KIDSVIHFAGLKAVG----ESTQIPLRYYHNNILGTVVLLE--- 120 + ++ ++ +++ AG+ +G S N+ G ++ + Sbjct: 86 PDSVTEMSSRVGELIPHLNVLVNAAGVLQLGGIEETSISEWEETLRVNLTGVYLVTKLLL 145 Query: 121 -LMQQYNVSKFVFSSSAT 137 L+++ + V +S Sbjct: 146 PLLRKAKWASIVNVASIA 163 >1Q7C-A nrPDB Length = 244 Score = 35.6 bits (80), Expect = 0.079, Method: Composition-based stats. Identities = 19/131 (14%), Positives = 46/131 (35%), Gaps = 13/131 (9%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 KI LVTG + IG L G + + ++ + + + ++ Sbjct: 4 EGKIALVTGASRGIGRAIAETLAARGAKVIG----TATSENGAQAISDYLGANGKGLMLN 59 Query: 70 LCDRKGLEKVFKEYK-----IDSVIHFAGLK----AVGESTQIPLRYYHNNILGTVVLLE 120 + D +E V ++ + +D +++ AG+ + + N+ L + Sbjct: 60 VTDPASIESVLEKIRAEFGEVDILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLSK 119 Query: 121 LMQQYNVSKFV 131 + + + K Sbjct: 120 AVMRAMMKKRH 130 >4DBZ-A nrPDB Length = 281 Score = 35.6 bits (80), Expect = 0.083, Method: Composition-based stats. Identities = 29/175 (16%), Positives = 53/175 (30%), Gaps = 31/175 (17%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 S++ LVTG IG L + G V ++ L D+ Sbjct: 26 SEVALVTGATSGIGLEIARRLGKEGLRVFVCARGEEGLRTTLKELREAGVEADG-RTCDV 84 Query: 71 CD----RKGLEKVFKEYKI-DSVIHFAGLKAVGESTQIPLRY----YHNNILG----TVV 117 + V + Y D +++ AG G + ++ N+ G T Sbjct: 85 RSVPEIEALVAAVVERYGPVDVLVNNAGRPGGGATAELADELWLDVVETNLTGVFRVTKQ 144 Query: 118 LLEL--MQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAI 170 +L+ M + + V +S G + PY +K+ + Sbjct: 145 VLKAGGMLERGTGRIVNIAST---GGKQGLVHAA------------PYSASKHGV 184 >1E3W-A nrPDB Length = 261 Score = 35.6 bits (80), Expect = 0.084, Method: Composition-based stats. Identities = 24/125 (19%), Positives = 47/125 (37%), Gaps = 19/125 (15%) Query: 13 IVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCD 72 + ++TGGA +G T L+ G V+ D + + L + I F ++ Sbjct: 12 VAVITGGASGLGLSTAKRLVGQGATAVLLDV---PNSEGETEAKKLGGNCI-FAPANVTS 67 Query: 73 RKGLEKVFKEYK-----IDSVIHFAGLKAVGESTQIPLRYYHN----------NILGTVV 117 K ++ K ID ++ AG+ ++ H N++GT Sbjct: 68 EKEVQAALTLAKEKFGRIDVAVNCAGIAVAIKTYHEKKNQVHTLEDFQRVINVNLIGTFN 127 Query: 118 LLELM 122 ++ L+ Sbjct: 128 VIRLV 132 >2UVD-A nrPDB Length = 246 Score = 35.6 bits (80), Expect = 0.088, Method: Composition-based stats. Identities = 21/141 (14%), Positives = 52/141 (36%), Gaps = 13/141 (9%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYE 67 K+ LVTG + IG ++L + G + VV + + V Sbjct: 1 MLKGKVALVTGASRGIGRAIAIDLAKQGANVVVNYAGNEQKANEVVDEIKKLGSDAIAVR 60 Query: 68 VDLCDRKGLEKVFKE-----YKIDSVIHFAGLK----AVGESTQIPLRYYHNNILGTVVL 118 D+ + + + + K+ ++D +++ AG+ + + + N+ G + Sbjct: 61 ADVANAEDVTNMVKQTVDVFGQVDILVNNAGVTKDNLLMRMKEEEWDTVINTNLKGVFLC 120 Query: 119 LELMQQY----NVSKFVFSSS 135 + + ++ + V +S Sbjct: 121 TKAVSRFMMRQRHGRIVNIAS 141 >3OML-A nrPDB Length = 613 Score = 35.2 bits (79), Expect = 0.091, Method: Composition-based stats. Identities = 30/151 (19%), Positives = 58/151 (38%), Gaps = 21/151 (13%) Query: 11 SKIVLVTG-GAGYIGSHTVVELIENGYDCVVAD---------NLSNSTYDSVARLEVLTK 60 ++ +VTG GAG +G + E G VV D + V + Sbjct: 19 GRVAVVTGAGAG-LGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRKAGG 77 Query: 61 HHIPFYEVDLCDRKGLEKVFKEY-KIDSVIHFAG----LKAVGESTQIPLRYYHNNILGT 115 + Y + K +E K + ++D +++ AG V S Q ++ G+ Sbjct: 78 EAVADYNSVIDGAKVIETAIKAFGRVDILVNNAGILRDRSLVKTSEQDWNLVNDVHLKGS 137 Query: 116 VVLLEL----MQQYNVSKFVFSSS-ATVYGD 141 + M++ N + + +SS + +YG+ Sbjct: 138 FKCTQAAFPYMKKQNYGRIIMTSSNSGIYGN 168 >3O4R-A nrPDB Length = 261 Score = 34.8 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 33/173 (19%), Positives = 61/173 (35%), Gaps = 28/173 (16%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARL--EVLTKHHIPFYEV 68 +K+ LVT IG L ++G VV+ + +VA L E L+ + Sbjct: 15 NKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVG 74 Query: 69 DLCDRKGLEKVFKE--YKIDSVIHFAGL-----KAVGESTQIPLRYYHNNI----LGTVV 117 DR+ L + ID ++ A + + + ++ + N+ L T Sbjct: 75 KAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKA 134 Query: 118 LLELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAI 170 ++ M++ V SS + P +PY +K A+ Sbjct: 135 VVPEMEKRGGGSVVIVSSIAAF---------------SPSPGFSPYNVSKTAL 172 >2ZCU-A nrPDB Length = 286 Score = 34.8 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 33/226 (14%), Positives = 67/226 (29%), Gaps = 27/226 (11%) Query: 13 IVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCD 72 ++ +TG G +G + + L++ + + N A+ + L I + D D Sbjct: 1 MIAITGATGQLGHYVIESLMKTVPASQIVAIVRNP-----AKAQALAAQGITVRQADYGD 55 Query: 73 RKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFVF 132 L + + L + S H N++ + V + Sbjct: 56 EAALTSALQGVE--------KLLLISSSEVGQRAPQHRNVI------NAAKAAGVKFIAY 101 Query: 133 SSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAILRY 192 ++ ++ D + E + + + N Y+ + + A L + Sbjct: 102 --TSLLHADTSPLGLADEHIETEKML-----ADSGIVYTLLRNGWYSENYLASAPAALEH 154 Query: 193 FNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYD 238 IGA G I + A G K+Y D Sbjct: 155 GVFIGAAGDGKIASATRADYAAAAARVISEA-GHEGKVYELAGDSA 199 >3H0K-A nrPDB Length = 178 Score = 34.8 bits (78), Expect = 0.13, Method: Composition-based stats. Identities = 17/81 (20%), Positives = 28/81 (34%), Gaps = 3/81 (3%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARL-EVLTK--HHIPFYEV 68 K++L+TG G S L E G +V ++ Y A+ E L + Sbjct: 1 KVILITGMPGSGKSEFAKLLKERGAKVIVMSDVVRKRYSIEAKPGERLMDFAKRLREIYG 60 Query: 69 DLCDRKGLEKVFKEYKIDSVI 89 D + + D V+ Sbjct: 61 DGVVARLCVEELGTSNHDLVV 81 >2QK4-A nrPDB Length = 452 Score = 34.8 bits (78), Expect = 0.13, Method: Composition-based stats. Identities = 27/160 (16%), Positives = 44/160 (27%), Gaps = 17/160 (10%) Query: 2 TAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKH 61 T L +S + VL+ G G HT+ + + + Sbjct: 15 TENLYFQSMAARVLIIGSGGR--EHTLAWKLAQSHHV-------KQVLVAPGNAGTACSE 65 Query: 62 HIPFYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLEL 121 I + + D L + KE KI+ V+ + LR G E Sbjct: 66 KISNTAISISDHTALAQFCKEKKIEFVV-VGPEAPLAAGIVGNLRSAGVQCFGPTA--EA 122 Query: 122 MQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTN 161 Q + +F A + D P P + Sbjct: 123 AQLESSKRF-----AKEFMDRHGIPTAQWKAFTKPEEACS 157 >5CDY-A nrPDB Length = 244 Score = 34.8 bits (78), Expect = 0.13, Method: Composition-based stats. Identities = 20/132 (15%), Positives = 46/132 (34%), Gaps = 19/132 (14%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 KI LVTG + IG L+E G + + ++ + + ++ Sbjct: 4 EGKIALVTGASRGIGRAIAELLVERGACVIG----TATSEKGAEAISAYLGENGKGLMLN 59 Query: 70 LCDRKGLEKVFKEYK-----IDSVIHFAG-------LKAVGESTQIPLRYYHNNILGTVV 117 + D ++ V + +D +++ AG ++ + Q N+ Sbjct: 60 VVDPTSIDTVLATIRAEFGEVDILVNNAGITRDNLLMRMKDDEWQD---IIDTNLTSVFR 116 Query: 118 LLELMQQYNVSK 129 L + + + + K Sbjct: 117 LSKAVMRAMMKK 128 >3T7C-A nrPDB Length = 299 Score = 34.8 bits (78), Expect = 0.13, Method: Composition-based stats. Identities = 35/153 (22%), Positives = 55/153 (35%), Gaps = 28/153 (18%) Query: 10 TSKIVLVTGGA-GYIGSHTVVELIENGYDCVVAD--------NLSNSTYDSVA---RLEV 57 K+ +TG A G SH + L G D + D L ST D +A R Sbjct: 27 EGKVAFITGAARGQGRSH-AITLAREGADIIAIDVCKQLDGVKLPMSTPDDLAETVRQVE 85 Query: 58 LTKHHIPFYEVDLCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGE--STQIPLRY--- 107 I +VD+ D ++ + ++D V+ A L + G + P + Sbjct: 86 ALGRRIIASQVDVRDFDAMQAAVDDGVTQLGRLDIVLANAALASEGTRLNRMDPKTWRDM 145 Query: 108 YHNNILG-----TVVLLELMQQYNVSKFVFSSS 135 N+ G V + +M VF+SS Sbjct: 146 IDVNLNGAWITARVAIPHIMAGKRGGSIVFTSS 178 >3VKI-A nrPDB Length = 219 Score = 34.8 bits (78), Expect = 0.13, Method: Composition-based stats. Identities = 30/165 (18%), Positives = 55/165 (33%), Gaps = 14/165 (8%) Query: 135 SATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAILRYFN 194 S V PN++P E+ + G K + ++K+ + + N Sbjct: 19 SDEVVVTLRSSPNLLPSCEQPAF---SMTGSAKLWGNVNVVARCANEKRYLQVNVQATGN 75 Query: 195 PIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYIHVVDL 254 + P+ L P + GR ++L D I+D + + DL Sbjct: 76 YVAV-------AAPIARGGKLTPANVTLKRGRLDQLP----PRTVLDIRQIQDAVSLRDL 124 Query: 255 AKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKAS 299 A G L + + R + +G+G +V A A+ Sbjct: 125 APGQPVQLTMIRQAWRVKAGQRVQVIANGEGFSVNAEGQAMNNAA 169 >3PPI-A nrPDB Length = 281 Score = 34.8 bits (78), Expect = 0.14, Method: Composition-based stats. Identities = 15/74 (20%), Positives = 27/74 (36%), Gaps = 4/74 (5%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYE 67 + +V+GGAG +G TV L +G V+AD + L + F Sbjct: 27 QFEGASAIVSGGAGGLGEATVRRLHADGLGVVIADLAAEKGKALADEL----GNRAEFVS 82 Query: 68 VDLCDRKGLEKVFK 81 ++ + + Sbjct: 83 TNVTSEDSVLAAIE 96 >5O3Z-A nrPDB Length = 263 Score = 34.4 bits (77), Expect = 0.16, Method: Composition-based stats. Identities = 18/83 (21%), Positives = 33/83 (39%), Gaps = 3/83 (3%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVAD-NLSNSTYDSVARLEVLTKHHIPFY 66 + ++ +V GG +G+ L + GY VAD N SN+ + + Sbjct: 3 MAMEQVAVVIGGGQTLGAFLCEGLAQAGYHVAVADLNESNANRLADTINSRYGAGRAYGF 62 Query: 67 EVDLCDRKGLEKVFKEYKIDSVI 89 +VD D +E + + +D Sbjct: 63 KVDATDEASVEALAR--AVDETF 83 >1HXH-A nrPDB Length = 253 Score = 34.4 bits (77), Expect = 0.19, Method: Composition-based stats. Identities = 17/77 (22%), Positives = 24/77 (31%), Gaps = 4/77 (5%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYE 67 K+ LVTGGA +G V L+ G +D + A L F Sbjct: 3 RLQGKVALVTGGASGVGLEVVKLLLGEGAKVAFSDINEAAGQQLAAEL----GERSMFVR 58 Query: 68 VDLCDRKGLEKVFKEYK 84 D+ V + Sbjct: 59 HDVSSEADWTLVMAAVQ 75 >3KYB-A nrPDB Length = 390 Score = 34.4 bits (77), Expect = 0.19, Method: Composition-based stats. Identities = 11/35 (31%), Positives = 18/35 (51%), Gaps = 1/35 (2%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLS 45 SK +L+ G AG+ G+ +L E G+ + D Sbjct: 3 SKKILIVG-AGFSGAVIGRQLAEKGHQVHIIDQRD 36 >3MJ4-A nrPDB Length = 397 Score = 33.6 bits (75), Expect = 0.26, Method: Composition-based stats. Identities = 13/42 (30%), Positives = 18/42 (42%), Gaps = 1/42 (2%) Query: 2 TAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADN 43 T Q ES L+ G AG+ GS L +G ++ D Sbjct: 20 TTNEQQESKGFDYLIVG-AGFAGSVLAERLASSGQRVLIVDR 60 >6BAL-A nrPDB Length = 335 Score = 33.6 bits (75), Expect = 0.32, Method: Composition-based stats. Identities = 10/23 (43%), Positives = 12/23 (52%) Query: 2 TAQLQSESTSKIVLVTGGAGYIG 24 T L +S + V V G AG IG Sbjct: 15 TENLYFQSNAMKVAVLGAAGGIG 37 >6ACQ-A nrPDB Length = 302 Score = 33.6 bits (75), Expect = 0.33, Method: Composition-based stats. Identities = 17/97 (17%), Positives = 30/97 (30%), Gaps = 12/97 (12%) Query: 9 STSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEV 68 S K V V G AG +GS G++ V+ D + + + + Sbjct: 19 SHMKKVCVIG-AGTMGSGIAQAFAAKGFEVVLRDIKDEFVDRGLDFINKNLSKLVK--KG 75 Query: 69 DLCDRKGLE---------KVFKEYKIDSVIHFAGLKA 96 + + +E + D VI A + Sbjct: 76 KIEEATKVEILTRISGTVDLNMAADCDLVIEAAVERM 112 >4E21-A nrPDB Length = 358 Score = 33.6 bits (75), Expect = 0.33, Method: Composition-based stats. Identities = 14/41 (34%), Positives = 23/41 (56%), Gaps = 3/41 (7%) Query: 2 TAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVAD 42 T L +S +I ++ G G +G+ V L + G++CVV D Sbjct: 15 TENLYFQSM-QIGMI--GLGRMGADMVRRLRKGGHECVVYD 52 >3LYL-A nrPDB Length = 247 Score = 33.2 bits (74), Expect = 0.34, Method: Composition-based stats. Identities = 23/115 (20%), Positives = 42/115 (36%), Gaps = 16/115 (13%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKH---HIPFY 66 K+ LVTG + IG L G V + ++ S + E K Sbjct: 4 NEKVALVTGASRGIGFEVAHALASKGATVVG----TATSQASAEKFENSMKEKGFKARGL 59 Query: 67 EVDLCDRKGLEKVFKEYK-----IDSVIHFAGLK----AVGESTQIPLRYYHNNI 112 +++ D + ++ F E K ID +++ AG+ + S + N+ Sbjct: 60 VLNISDIESIQNFFAEIKAENLAIDILVNNAGITRDNLMMRMSEDEWQSVINTNL 114 >5ER0-A nrPDB Length = 518 Score = 33.2 bits (74), Expect = 0.34, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 24/71 (33%), Gaps = 9/71 (12%) Query: 5 LQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIP 64 ++ +K + V G AGYIG+ G+D + D ++ + Sbjct: 191 IEDAKEAKRITVIG-AGYIGAELAEAYSTTGHDVTLIDAMARV-------MPKYFDADFT 242 Query: 65 FY-EVDLCDRK 74 E D D Sbjct: 243 DVIEQDYRDHG 253 >3UF0-A nrPDB Length = 273 Score = 33.2 bits (74), Expect = 0.36, Method: Composition-based stats. Identities = 22/109 (20%), Positives = 36/109 (33%), Gaps = 19/109 (17%) Query: 2 TAQLQSEST-------SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVAR 54 T L +S + +VTG IG GY A L+ D V Sbjct: 15 TENLYFQSMTGPFSLAGRTAVVTGAGSGIGRAIAH-----GYARAGAHVLAWGRTDGVKE 69 Query: 55 LEVLTKHHIPFYEVDLCDRKGL-------EKVFKEYKIDSVIHFAGLKA 96 + E + D L E++ ++D +++ AG+ A Sbjct: 70 VADEIADGGGSAEAVVADLADLEGAANVAEELAATRRVDVLVNNAGIIA 118 >3BHI-A nrPDB Length = 276 Score = 33.2 bits (74), Expect = 0.37, Method: Composition-based stats. Identities = 36/200 (18%), Positives = 64/200 (32%), Gaps = 47/200 (23%) Query: 13 IVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCD 72 + LVTGG IG V +L VV + + + F+++D+ D Sbjct: 6 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDD 65 Query: 73 RKGLEKVFK-----EYKIDSVIHFAGLKAVGESTQIPLRY-------YHNNILGT----V 116 + + + +D +++ AG+ P + N GT Sbjct: 66 LQSIRALRDFLRKEYGGLDVLVNNAGIAF---KVADPTPFHIQAEVTMKTNFFGTRDVCT 122 Query: 117 VLLELMQQYNVSKFVFSSSA-------TVYGDATRFPNMIPIPEECPLG----------- 158 LL L++ + V SS + + + I EE +G Sbjct: 123 ELLPLIKPQG--RVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKK 180 Query: 159 --------PTNPYGHTKYAI 170 P++ YG TK + Sbjct: 181 GVHQKEGWPSSAYGVTKIGV 200 >2DKN-A nrPDB Length = 255 Score = 33.2 bits (74), Expect = 0.42, Method: Composition-based stats. Identities = 36/201 (17%), Positives = 60/201 (29%), Gaps = 35/201 (17%) Query: 13 IVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCD 72 ++ +TG A IG+ L G+ + D D A L + D Sbjct: 3 VIAITGSASGIGAALKELLARAGHTVIGID---RGQADIEADLSTPGGRETAV--AAVLD 57 Query: 73 RKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQY-----NV 127 R G +D ++ AG VG + N G LL+ + + Sbjct: 58 RCG-------GVLDGLVCCAG---VGVTAANSGLVVAVNYFGVSALLDGLAEALSRGQQP 107 Query: 128 SKFVFSSSATVYGDATRFPNMIPI---PE-------ECPLGPTNPYGHTKYAIENILNDL 177 + + S A A P + + E E Y +KYA+ + Sbjct: 108 AAVIVGSIAATQPGAAELPMVEAMLAGDEARAIELAEQQGQTHLAYAGSKYAVTCLARR- 166 Query: 178 YNSDKKSWKFAILRYFNPIGA 198 + W +R N + Sbjct: 167 ---NVVDWAGRGVRL-NVVAP 183 >4NBV-A nrPDB Length = 246 Score = 32.9 bits (73), Expect = 0.48, Method: Composition-based stats. Identities = 26/148 (17%), Positives = 55/148 (37%), Gaps = 15/148 (10%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYE 67 + ++ ++TG A IG T E+G VV ++ + A T + Y Sbjct: 2 KLQGRVAIITGAAAGIGFATAQRFAEDG-AIVVLCDVQEARVREAAARLAATGATVSAYR 60 Query: 68 VDLCDRKGLEKVFKEY-----KIDSVIHFAGL----KAVGESTQIPLRYYHNNILGTVVL 118 VD+ R ++ + ++D +++ AG+ + + N+ G Sbjct: 61 VDVTRRDEVDAMVAAVLAAHQRVDILVNNAGITKDARLAKMTEAQFDAVIDVNLKGVFNC 120 Query: 119 LEL----MQQYNVSKFVFSSS-ATVYGD 141 + M + + +SS +YG+ Sbjct: 121 AQAVAGLMTEQGKGVILNASSVVGLYGN 148 >4OV4-A nrPDB Length = 414 Score = 32.9 bits (73), Expect = 0.50, Method: Composition-based stats. Identities = 29/140 (20%), Positives = 50/140 (35%), Gaps = 8/140 (5%) Query: 359 GVEARFSAEDMRYDARFVTIG-AGTRFQATFANLGASIVDLKVNGQSVVLGYENEEGYLN 417 G+ S E + A + + G +A NL + + L NG+++ + ++ Sbjct: 233 GMATATSVESVYVGAEQIEVALNGLGERAGNTNLYETAIALHQNGENLNINFQRIYPTAK 292 Query: 418 PDSAYIGATIGRYANRISKGKFSLCNKDYQLTVNNGVNANHSSIGSFHRKRFLGPIIQNP 477 S G IG I + FS + +Q V H S G++ + F + Sbjct: 293 RISELTGIPIGEKTPIIGEDIFSHRSGIHQDGVT---KTLHQSKGAY--RTFSPEFV--G 345 Query: 478 SKDVFTAEYMLIDNEKDTEF 497 D T + K EF Sbjct: 346 RMDKETISFTNQSGHKAIEF 365 >2ZAT-A nrPDB Length = 260 Score = 32.9 bits (73), Expect = 0.52, Method: Composition-based stats. Identities = 33/178 (18%), Positives = 61/178 (34%), Gaps = 36/178 (20%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 +K+ LVT IG L ++G VV S+ ++V R + Sbjct: 13 ENKVALVTASTDGIGLAIARRLAQDGAHVVV----SSRKQENVDRTVATLQGEGLSVTGT 68 Query: 70 LC------DRKGLE--KVFKEYKIDSVIHFAGL-----KAVGESTQIPLRYYHNNILGTV 116 +C DR+ L V +D ++ A + + + ++ + H N+ TV Sbjct: 69 VCHVGKAEDRERLVAMAVNLHGGVDILVSNAAVNPFFGNIIDATEEVWDKILHVNVKATV 128 Query: 117 VLLEL----MQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAI 170 ++ + M++ + SS Y P PY +K A+ Sbjct: 129 LMTKAVVPEMEKRGGGSVLIVSSVGAY---------------HPFPNLGPYNVSKTAL 171 >1CYD-A nrPDB Length = 244 Score = 32.9 bits (73), Expect = 0.52, Method: Composition-based stats. Identities = 27/90 (30%), Positives = 36/90 (40%), Gaps = 6/90 (6%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 + LVTG IG TV L +G VVA +NS S+A+ I VD Sbjct: 6 SGLRALVTGAGKGIGRDTVKALHASGAK-VVAVTRTNSDLVSLAK----ECPGIEPVCVD 60 Query: 70 LCDRKGLEKVFKEYKI-DSVIHFAGLKAVG 98 L D EK D +++ A L + Sbjct: 61 LGDWDATEKALGGIGPVDLLVNNAALVIMQ 90 >3PQF-A nrPDB Length = 326 Score = 32.9 bits (73), Expect = 0.54, Method: Composition-based stats. Identities = 15/71 (21%), Positives = 24/71 (33%), Gaps = 4/71 (5%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGY--DCVVADNLSNSTYDSVARLEVLTKHHIPFYEV 68 +K+ L+ GAG++GS LI G + VV D V L + Sbjct: 6 NKVALI--GAGFVGSSYAFALINQGITDELVVIDVNKEKAMGDVMDLNHGKAFAPQPVKT 63 Query: 69 DLCDRKGLEKV 79 + + Sbjct: 64 SYGTYEDCKDA 74 >4DA9-A nrPDB Length = 280 Score = 32.9 bits (73), Expect = 0.56, Method: Composition-based stats. Identities = 29/140 (20%), Positives = 51/140 (36%), Gaps = 16/140 (11%) Query: 2 TAQLQSESTSK-----IVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLE 56 T L +S + +VTGG IG L +G+D + V Sbjct: 15 TENLYFQSMMTQKARPVAIVTGGRRGIGLGIARALAASGFDIAITGIGDAEGVAPVIAEL 74 Query: 57 VLTKHHIPFYEVDLCD----RKGLEKVFKEY-KIDSVIHFAGL-KAVGESTQI--PLRY- 107 + F DL D + ++ V E+ +ID +++ AG+ V + P + Sbjct: 75 SGLGARVIFLRADLADLSSHQATVDAVVAEFGRIDCLVNNAGIASIVRDDFLDLKPENFD 134 Query: 108 --YHNNILGTVVLLELMQQY 125 N+ GTV + + + Sbjct: 135 TIVGVNLRGTVFFTQAVLKA 154 >5A9T-A nrPDB Length = 290 Score = 32.5 bits (72), Expect = 0.57, Method: Composition-based stats. Identities = 27/145 (18%), Positives = 49/145 (33%), Gaps = 17/145 (11%) Query: 10 TSKIVLVT-GGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEV 68 T + + VT G G +GS L++ G+D V + VA+ + Sbjct: 2 TDQNLPVTVAGLGPMGSALAAALLDRGHDVTVWNRSPGKAAPLVAKGARQADDIVDAVSA 61 Query: 69 D------LCDRKGLEKVF----KEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVV- 117 L D L + + V++ + LR+ + G + Sbjct: 62 SRLLVVCLADYDALYSALGPAREALRGRVVVNL--NSGTPKEANEALRWAERHGTGYLDG 119 Query: 118 ---LLELMQQYNVSKFVFSSSATVY 139 + M + S F++S SA V+ Sbjct: 120 AIMVPPAMVGHPGSVFLYSGSAEVF 144 >4ECM-A nrPDB Length = 269 Score = 32.5 bits (72), Expect = 0.58, Method: Composition-based stats. Identities = 12/72 (16%), Positives = 22/72 (30%), Gaps = 15/72 (20%) Query: 2 TAQLQSEST-SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTK 60 T L +S K +++ GG G ++N V R ++ Sbjct: 15 TENLYFQSNAMKGIILAGGTG--------------SRLYPITKVTNKHLLPVGRYPMIYH 60 Query: 61 HHIPFYEVDLCD 72 + D+ D Sbjct: 61 AVYKLKQCDITD 72 >4RZI-B nrPDB Length = 240 Score = 32.5 bits (72), Expect = 0.59, Method: Composition-based stats. Identities = 14/64 (21%), Positives = 27/64 (42%), Gaps = 2/64 (3%) Query: 12 KIVLVTGGAGYIGSHTVVELIENGYDCVVAD-NLSNSTYDSVARLEVLTK-HHIPFYEVD 69 K+++VTGG IG+ V L E G D +++ + +T + + Sbjct: 9 KVIVVTGGNRGIGAAIVKLLQEMGAKVAFTDLATDGGNTEALGVVANVTDLESMTAAAAE 68 Query: 70 LCDR 73 + D+ Sbjct: 69 ITDK 72 >3AUT-A nrPDB Length = 269 Score = 32.5 bits (72), Expect = 0.60, Method: Composition-based stats. Identities = 33/185 (17%), Positives = 70/185 (37%), Gaps = 31/185 (16%) Query: 5 LQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVV-ADNLSNSTYDSVARLEVLTKHHI 63 + ++ K+V++TGG+ +G V + V+ N D+ +E I Sbjct: 9 MYTDLKDKVVVITGGSTGLGRAMAVRFGQEEAKVVINYYNNEEEALDAKKEVEEAGGQAI 68 Query: 64 PFYEVDLCDRK----GLEKVFKEYK-IDSVIHFAGLKAVGESTQIPLR----YYHNNILG 114 + D+ + ++ KE+ +D +I+ AG++ S ++ L N+ G Sbjct: 69 -IVQGDVTKEEDVVNLVQTAIKEFGTLDVMINNAGVENPVPSHELSLDNWNKVIDTNLTG 127 Query: 115 -TVVLLELMQ---QYNVS-KFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYA 169 + E ++ + ++ + SS MIP PL Y +K Sbjct: 128 AFLGSREAIKYFVENDIKGNVINMSS---------VHEMIPW----PLFVH--YAASKGG 172 Query: 170 IENIL 174 ++ + Sbjct: 173 MKLMT 177 >4TRR-A nrPDB Length = 269 Score = 32.5 bits (72), Expect = 0.61, Method: Composition-based stats. Identities = 21/108 (19%), Positives = 39/108 (36%), Gaps = 11/108 (10%) Query: 7 SESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFY 66 S K +VTG A IG +EL + G +AD + + I Sbjct: 10 SNLNGKTAVVTGAASGIGKEIALELAKAGAAVAIADLNQDGANAVADEINKAGGKAIG-V 68 Query: 67 EVDLCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGESTQIPLRYYH 109 +D+ + + + + +D ++ AG++ V P+ Y Sbjct: 69 AMDVTNEEAVNTGIDKVAEAFGSVDILVSNAGIQIV-----NPIENYS 111 >4HP8-A nrPDB Length = 247 Score = 32.5 bits (72), Expect = 0.62, Method: Composition-based stats. Identities = 31/191 (16%), Positives = 55/191 (28%), Gaps = 19/191 (9%) Query: 7 SESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFY 66 + LVTG +G V L G + V A + D + + Sbjct: 5 FSLEGRKALVTGANTGLGQAIAVGLAAAGAEVVCA---ARRAPDETLDIIAKDGGNASAL 61 Query: 67 EVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQ----IPLRYYHNNI----LGTVVL 118 +D D + F + D +++ AG+ +S + N+ T Sbjct: 62 LIDFADPLAAKDSFTDAGFDILVNNAGIIRRADSVEFSELDWDEVMDVNLKALFFTTQAF 121 Query: 119 L-ELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDL 177 EL+ + K V +S + R P+ G TK Sbjct: 122 AKELLAKGRSGKVVNIASLLSFQGGIRVPSYTAAK-------HGVAGLTKLLANEWAAKG 174 Query: 178 YNSDKKSWKFA 188 N + + + Sbjct: 175 INVNAIAPGYI 185 >3OIC-A nrPDB Length = 258 Score = 32.5 bits (72), Expect = 0.63, Method: Composition-based stats. Identities = 17/82 (20%), Positives = 33/82 (40%), Gaps = 2/82 (2%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYE 67 +K LVTG + +G + L ENGY+ V+ S A + + Sbjct: 1 MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALETAEEIEKLGVKVLVVK 60 Query: 68 VDLCDRKGLEKVFKEYKIDSVI 89 ++ ++++F+ +ID Sbjct: 61 ANVGQPAKIKEMFQ--QIDETF 80 >1GEE-A nrPDB Length = 261 Score = 32.5 bits (72), Expect = 0.66, Method: Composition-based stats. Identities = 27/180 (15%), Positives = 59/180 (32%), Gaps = 21/180 (11%) Query: 5 LQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIP 64 + + K+V++TG + +G + VV +SV Sbjct: 1 MYKDLEGKVVVITGSSTGLGKSMAIRFATEKAKVVVNYRSKEDEANSVLEEIKKVGGEAI 60 Query: 65 FYEVDLCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGESTQIPLRY----YHNNILG- 114 + D+ + + + K+D +I+ AGL+ S ++ L N+ G Sbjct: 61 AVKGDVTVESDVINLVQSAIKEFGKLDVMINNAGLENPVSSHEMSLSDWNKVIDTNLTGA 120 Query: 115 TVVLLELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENIL 174 + E ++ + + NM + E+ P Y +K ++ + Sbjct: 121 FLGSREAIKYFVENDI-----------KGTVINMSSVHEKIPWPLFVHYAASKGGMKLMT 169 >4DMM-A nrPDB Length = 269 Score = 32.5 bits (72), Expect = 0.68, Method: Composition-based stats. Identities = 21/89 (23%), Positives = 33/89 (37%), Gaps = 5/89 (5%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 T +I LVTG + IG +EL G V S D V + D Sbjct: 27 TDRIALVTGASRGIGRAIALELAAAGAKVAVNYASSAGAADEVVAAIAAAGGEAFAVKAD 86 Query: 70 LCDRKGLEKVFKE-----YKIDSVIHFAG 93 + +E +F ++D +++ AG Sbjct: 87 VSQESEVEALFAAVIERWGRLDVLVNNAG 115 >2CDH-G nrPDB Length = 244 Score = 32.5 bits (72), Expect = 0.70, Method: Composition-based stats. Identities = 22/87 (25%), Positives = 37/87 (42%), Gaps = 7/87 (8%) Query: 13 IVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVAR-LEVLTKHHIPFYEVDLC 71 +V+VTG + IG + L + G +V S + V++ +E I F D+ Sbjct: 3 VVVVTGASRGIGKAIALSLGKAGCKVLVNYARSAKAAEEVSKQIEAYGGQAITF-GGDVS 61 Query: 72 DRKGLEKVFKE-----YKIDSVIHFAG 93 +E + K ID V++ AG Sbjct: 62 KEADVEAMMKTAIDAWGTIDVVVNNAG 88 >4CQM-B nrPDB Length = 244 Score = 32.1 bits (71), Expect = 0.77, Method: Composition-based stats. Identities = 30/169 (17%), Positives = 60/169 (35%), Gaps = 26/169 (15%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDC-VVADNLSNSTYDSVARLEVLTKHHIPFYEV 68 K+ V GG+ IG + GY V+A NL + + L H+ F Sbjct: 8 MDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAA----GDLGGDHLAF-SC 62 Query: 69 DLCDRKGLEKVFKE-----YKIDSVIHFAGLK----AVGESTQIPLRYYHNNILGTVVLL 119 D+ ++ F+E +++ +++ AG+ V T+ + H N+LG+++ Sbjct: 63 DVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTC 122 Query: 120 ELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKY 168 + + + + S G + Y +K Sbjct: 123 KAAMRTMIQQ--QGGSIVNVGSIVGLKGNSGQ---------SVYSASKG 160 >1V9L-A nrPDB Length = 421 Score = 32.1 bits (71), Expect = 0.83, Method: Composition-based stats. Identities = 17/109 (15%), Positives = 31/109 (28%), Gaps = 12/109 (11%) Query: 1 MTAQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTK 60 M +L K V + G G +G T L + G + +++ Y L + Sbjct: 200 MAKKLWGGIEGKTVAIQG-MGNVGRWTAYWLEKMGAKVIAVSDINGVAYRKEGLNVELIQ 258 Query: 61 HHIPFYEVDL------CDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQI 103 + L D K D++ V + + Sbjct: 259 KNKGLTGPALVELFTTKDNAEFVK-----NPDAIFKLDVDIFVPAAIEN 302 >3E9N-A nrPDB Length = 245 Score = 32.1 bits (71), Expect = 0.86, Method: Composition-based stats. Identities = 28/182 (15%), Positives = 67/182 (36%), Gaps = 27/182 (14%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 KI +VTG G +G V +L + + N ++A +E + + ++ Sbjct: 5 KKIAVVTGATGGMGIEIVKDLSRDHIVYALGRN--PEHLAALAEIEGVEPIESDIVK-EV 61 Query: 71 CDRKGLEKVFKEYKIDSVIHFAGLKAVGE----STQIPLRYYHNNIL----GTVVLLELM 122 + G++K+ +D+++H A + S + N++ + LL + Sbjct: 62 LEEGGVDKLKNLDHVDTLVHAAAVARDTTIEAGSVAEWHAHLDLNVIVPAELSRQLLPAL 121 Query: 123 QQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDK 182 + + ++ +S G+ N I Y +K+A+ + + + Sbjct: 122 RAASG-CVIYINSGA--GNGPHPGNTI-------------YAASKHALRGLADAFRKEEA 165 Query: 183 KS 184 + Sbjct: 166 NN 167 >1LSS-A nrPDB Length = 140 Score = 32.1 bits (71), Expect = 0.87, Method: Composition-based stats. Identities = 10/34 (29%), Positives = 16/34 (47%), Gaps = 1/34 (2%) Query: 9 STSKIVLVTGGAGYIGSHTVVELIENGYDCVVAD 42 S +++ G G +G L E G+D V+ D Sbjct: 2 SHGMYIIIAGI-GRVGYTLAKSLSEKGHDIVLID 34 >4DRY-A nrPDB Length = 281 Score = 31.7 bits (70), Expect = 0.99, Method: Composition-based stats. Identities = 34/184 (18%), Positives = 62/184 (33%), Gaps = 20/184 (10%) Query: 2 TAQLQSEST---------SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSV 52 T L +S +I LVTGG +G L GY V+ + + Sbjct: 15 TENLYFQSMMAQGKGSGEGRIALVTGGGTGVGRGIAQALSAEGYSVVITGRRPDVLDAAA 74 Query: 53 ARLEVLTKHHIPFYEVDLCDRKGLEKVFKEYKI-----DSVIHFAGLKAVGESTQIPLRY 107 + T + + D+ D + +F + D +++ AG V + + Sbjct: 75 GEIGGRTGNIVRAVVCDVGDPDQVAALFAAVRAEFARLDLLVNNAG-SNVPPVPLEEVTF 133 Query: 108 YHNNILGTVVLLEL-MQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHT 166 N + L + + + + + + R N I + P + PY T Sbjct: 134 EQWNGIVAANLTGAFLCTQHAFRMMKAQT----PRGGRIINNGSISAQTPRPNSAPYTAT 189 Query: 167 KYAI 170 K+AI Sbjct: 190 KHAI 193 >1NFF-A nrPDB Length = 260 Score = 31.7 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 26/143 (18%), Positives = 50/143 (34%), Gaps = 17/143 (11%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYE 67 T K+ LV+GGA +G+ V ++ G V D L A L + Sbjct: 4 RLTGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAMAAELADAA----RYVH 59 Query: 68 VDLCD----RKGLEKVFKEYKIDSV-IHFAGLKAVGESTQIPLRYY----HNNILGTVVL 118 +D+ + ++ + V ++ AG+ +G L + N+ G + Sbjct: 60 LDVTQPAQWKAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLG 119 Query: 119 LEL----MQQYNVSKFVFSSSAT 137 + M++ + SS Sbjct: 120 IRAVVKPMKEAGRGSIINISSIE 142 >4J8L-A nrPDB Length = 361 Score = 31.7 bits (70), Expect = 1.2, Method: Composition-based stats. Identities = 24/105 (22%), Positives = 41/105 (39%), Gaps = 15/105 (14%) Query: 15 LVTG-GAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCDR 73 LV G G G I + L++ G +V D T + + + + VD D Sbjct: 70 LVQGAGTGAIRAGLA-ALLKPGQRLLVHDAPVYPTTRVI-----IEQMGLTLITVDFNDL 123 Query: 74 KGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYH-NNILGTVV 117 L++V E + D+ + V + Q P Y ++L T+ Sbjct: 124 SALKQVVDEQQPDAAL-------VQHTRQQPQDSYVLADVLATLR 161 >6AQE-A nrPDB Length = 266 Score = 31.7 bits (70), Expect = 1.3, Method: Composition-based stats. Identities = 34/208 (16%), Positives = 64/208 (30%), Gaps = 43/208 (20%) Query: 132 FSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAILR 191 + +A + G+ + + Y K ++ IL + K ++ Sbjct: 33 QAQTAKLAGELAEWQERL-------------YAEGKQSLLLILQARDAAGKDGAVKKVIG 79 Query: 192 YFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRR----------EKLYIFGDDYDSRD 241 FNP G + + ++ L + Q A + E + + D Sbjct: 80 AFNPAGVQITSFKQPSAEELSHDFLWRIHQKAPAKGYVGVFNRSQYEDVLVTRVYDMIDD 139 Query: 242 GTPIRDYIHV-------VDLAKGHIAAL---------QYLEAYNENEGLCREWNLGSGKG 285 T R H+ D A + + L+A +N G ++N G K Sbjct: 140 KTAKRRLEHIRHFEELLTDNATRIVKVYLHISPEEQKERLQARLDNPGKHWKFNPGDLKD 199 Query: 286 STVF----EVYHAFCKASGIDLPYKVTG 309 + + +VY S D P+ V Sbjct: 200 RSNWDKFNDVYEDALTTSTDDAPWYVVP 227 >4UUM-A nrPDB Length = 341 Score = 31.7 bits (70), Expect = 1.3, Method: Composition-based stats. Identities = 11/28 (39%), Positives = 16/28 (57%), Gaps = 1/28 (3%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELIENG 35 S + VL+TG AG IG + + I +G Sbjct: 1 MSEAAHVLITGAAGQIG-YILSHWIASG 27 >5EJ2-A nrPDB Length = 308 Score = 31.3 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 29/133 (21%), Positives = 50/133 (37%), Gaps = 23/133 (17%) Query: 11 SKIVLVTGGA-GYIGSHTVVELIENGYDCVVAD------NLS--NSTYDSVARLEVLTKH 61 K+ ++G A G SH V L + G D + D NL+ +ST + +A L K Sbjct: 37 GKVAFISGAARGQGRSHAVR-LAQEGADIIAIDICGPIENLAYPHSTPEDLAETADLVKD 95 Query: 62 ---HIPFYEVDLCDRKGLEKVFKE-----YKIDSVIHFAGLKAVGESTQIP-----LRYY 108 I +VD+ D + L+ ++D ++ AG+ G Sbjct: 96 LDRRIVTAQVDVRDFEALKSAVDSGVEQLGRLDIIVANAGVGTDGRKLHKIRDNVWQDMI 155 Query: 109 HNNILGTVVLLEL 121 N+ G ++ Sbjct: 156 DINLTGVWHTVKA 168 >5X6R-A nrPDB Length = 420 Score = 31.3 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 17/91 (18%), Positives = 31/91 (34%), Gaps = 11/91 (12%) Query: 2 TAQLQS--ESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLT 59 T L S S+ V + G AG +G + + GY+ + D + RL+ Sbjct: 17 TENLYYFQGSMSESVAIIG-AGLVGCLAALAFSKEGYNVTLYDFRQDP------RLDTTK 69 Query: 60 KHHIPFYEVDLCDRKGLEKVFKEYKIDSVIH 90 ++ + + K D+ H Sbjct: 70 NKNLKSINLAI--SARGIDALKSIDPDACEH 98 >3F6T-A nrPDB Length = 533 Score = 31.3 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 22/143 (15%), Positives = 46/143 (32%), Gaps = 14/143 (9%) Query: 30 ELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCDRKGLEKVFKEYKIDSVI 89 L++ G + + + R+ L EVDL + + + +I+ + Sbjct: 188 HLLKKGDKIAI----NEPIFTPYLRIPEL--KDYELVEVDLHSYEKNDWEIEPNEIEKLK 241 Query: 90 HFAGLKAVGESTQIP-LRYYHNNILGTVVLLELMQQYNVSKFVFSSSATVYGDATRFPNM 148 + + + P + + N + ++ + N + S VYG PN Sbjct: 242 DPSIKALIVVNPTNPTSKEFDTNA---LNAIKQAVEKNPKLMI--ISDEVYG--AFVPNF 294 Query: 149 IPIPEECPLGPTNPYGHTKYAIE 171 I P Y ++K Sbjct: 295 KSIYSVVPYNTMLVYSYSKLFGC 317 >1P33-A nrPDB Length = 289 Score = 31.3 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 13/44 (29%), Positives = 21/44 (47%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVA 53 T+ + LVTG A +GS L GY + + S + ++A Sbjct: 6 TAPVALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAADASTLA 49 >2PH3-A nrPDB Length = 245 Score = 31.3 bits (69), Expect = 1.5, Method: Composition-based stats. Identities = 21/130 (16%), Positives = 43/130 (33%), Gaps = 15/130 (11%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDL 70 + L+TG + IG + L E+G+ + + + VA + Sbjct: 1 MRKALITGASRGIGRAIALRLAEDGFALAIHYGQNREKAEEVAEEARRRGSPLVAVLG-- 58 Query: 71 CDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTV-VLLELMQQYNVSK 129 + + +++H A G L NN T LL M+ + Sbjct: 59 ------ANLLEAEAATALVHQAAEVLGG------LDTLVNNAGITRDTLLVRMKDEDWEA 106 Query: 130 FVFSSSATVY 139 + ++ + V+ Sbjct: 107 VLEANLSAVF 116 >2LDB-A nrPDB Length = 317 Score = 31.3 bits (69), Expect = 1.6, Method: Composition-based stats. Identities = 43/259 (16%), Positives = 86/259 (33%), Gaps = 48/259 (18%) Query: 11 SKIVLVTGGAGYIGSHTVVELIENGY--DCVVAD---NLSNSTYDSVARLEVLTKHHIPF 65 +++V++ GAG++G+ V L+ G + V+ D + + +V + Sbjct: 7 ARVVVI--GAGFVGASYVFALMNQGIADEIVLIDANESKAIGDAMDFNHGKVFAPKPVDI 64 Query: 66 YEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQY 125 + D D + D V+ AG A + + L NI ++E + Sbjct: 65 WHGDYDDCRD---------ADLVVICAG--ANQKPGETRLDLVDKNIAIFRSIVESVMAS 113 Query: 126 NVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAI---ENILNDLYNSDK 182 ++ P+ Y K++ E ++ D Sbjct: 114 GFQGLFLVATN-------------PVDILT-------YATWKFSGLPHERVIGSGTILDT 153 Query: 183 KSWKFAILRYFNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRRE--KLYIFGDDYDSR 240 ++F + YF+ P + + LP +Q +G KL + + Sbjct: 154 ARFRFLLGEYFSVA---PQNVHAYIIGEHGDTELPVWSQAYIGVMPIRKLVESKGEEAQK 210 Query: 241 DGTPIRDYIHVVDLAKGHI 259 D R +++V D A I Sbjct: 211 DLE--RIFVNVRDAAYQII 227 >5T5Q-A nrPDB Length = 247 Score = 31.3 bits (69), Expect = 1.6, Method: Composition-based stats. Identities = 24/124 (19%), Positives = 41/124 (33%), Gaps = 11/124 (8%) Query: 4 QLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHI 63 ++ E ++ +++TG G IG +G + V+ D L D+ A + + I Sbjct: 2 SMKFEFENRTLVLTGANGGIGRAIAELFHASGANLVLTD-LDREGLDAFA-ASLGSPERI 59 Query: 64 PFYEVDLCDRKGLEKVFKE-----YKIDSVIHFA----GLKAVGESTQIPLRYYHNNILG 114 + D EK ID ++ A S R N+ G Sbjct: 60 ATIKADASSADDAEKTVALAMERFGGIDFLVPSAGIYQAKPFAEMSDADWHRTISINLDG 119 Query: 115 TVVL 118 L Sbjct: 120 VFYL 123 >3RP7-A nrPDB Length = 407 Score = 30.9 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 14/72 (19%), Positives = 27/72 (37%), Gaps = 4/72 (5%) Query: 3 AQLQSESTSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLS--NSTYDSVARLEVLTK 60 L + K +++ GAG G V L ++G DC V + + +++ K Sbjct: 16 ENLYFQGHMKAIVI--GAGIGGLSAAVALKQSGIDCDVYEAVKEIKPVGAAISVWPNGVK 73 Query: 61 HHIPFYEVDLCD 72 D+ + Sbjct: 74 CMAHLGMGDIME 85 >5OJG-A nrPDB Length = 260 Score = 30.9 bits (68), Expect = 1.9, Method: Composition-based stats. Identities = 10/72 (13%), Positives = 24/72 (33%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 K+ +VT IG L++ G V+ + +++ L+ + Sbjct: 9 EGKVAIVTAATKGIGLAIAERLLDEGASVVIGSRNQKNVDEAIEYLKNKGLTKVAGIAGH 68 Query: 70 LCDRKGLEKVFK 81 + +K+ Sbjct: 69 IASTDDQKKLVD 80 >5OKP-A nrPDB Length = 461 Score = 30.9 bits (68), Expect = 1.9, Method: Composition-based stats. Identities = 6/31 (19%), Positives = 14/31 (45%) Query: 326 KRELKWQTELQVEDSCKDLWKWTTENPFGYQ 356 + E+ + + E +D + W + P G + Sbjct: 235 EEEISFPPTYRYERGSRDTYAWHKQKPTGVR 265 >2UYY-A nrPDB Length = 316 Score = 30.9 bits (68), Expect = 2.0, Method: Composition-based stats. Identities = 13/47 (27%), Positives = 19/47 (40%), Gaps = 11/47 (23%) Query: 2 TAQLQSESTSKIVLVT------G--GAGYIGSHTVVELIENGYDCVV 40 T L +S +T G G G +GS V L++ G+ V Sbjct: 15 TENLYFQSMGS---ITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTV 58 >3NR8-B nrPDB Length = 316 Score = 30.9 bits (68), Expect = 2.0, Method: Composition-based stats. Identities = 6/31 (19%), Positives = 14/31 (45%) Query: 326 KRELKWQTELQVEDSCKDLWKWTTENPFGYQ 356 + E+ + + E +D + W + P G + Sbjct: 236 EEEISFPPTYRYERGSRDTYAWHKQKPTGVR 266 >3IB3-A nrPDB Length = 560 Score = 30.9 bits (68), Expect = 2.1, Method: Composition-based stats. Identities = 41/209 (19%), Positives = 71/209 (33%), Gaps = 42/209 (20%) Query: 435 SKGKFSLCNKDYQ-LTVNNGVNA-NHSSIGSFHRKRFLGPIIQNPSKDVFTAEYMLIDNE 492 S F L N +Y L +N + NH+ I S H ++ Q +T + Sbjct: 348 SASAFPLPNAEYTPLYLNAENHTLNHAKISSAHVAQYDSEDKQQDVSFKYTF-------D 400 Query: 493 KDTEFPGD--LLVTIQYTVNVAQKSLEMVYKGKLTAGEATPINLTNH------------- 537 KDTE G+ L + + T + L K G NH Sbjct: 401 KDTELVGNMNLKLWVS-TKDSDDMDLFAGIKKLDRRGNEVNFPDFNHIENGQVATGWLRV 459 Query: 538 SYFNLNKPYGDTIE-----GTEIMVRSKKSVDVDKNMIPTGNIVDREIATFNSTKPTVLG 592 S+ L++ + TE+ + + V V+ ++P+G + F + + Sbjct: 460 SHRELDQEKSSIAQPWHKHETELKLSQDEIVPVEIELLPSGTL-------FKQGETLEVV 512 Query: 593 PKNPQFDCCFVVDENAKPSQINTLNNELT 621 K + +V N+ P +E T Sbjct: 513 VKGSE-----IVIGNSTPGMKTRYEHEET 536 >6CHD-A nrPDB Length = 597 Score = 30.9 bits (68), Expect = 2.1, Method: Composition-based stats. Identities = 21/136 (15%), Positives = 45/136 (33%), Gaps = 6/136 (4%) Query: 194 NPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLY-IFGDDYDSRDGTPIRDYIHVV 252 N +G + DP + Q+ V + F D D ++ Sbjct: 62 NGVGPEEESV---DPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPG 118 Query: 253 DLA-KGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYKVTGRR 311 D + + A + G ++L G+G + + ++ S + + R Sbjct: 119 DHLTDITLKVAGRIHAKRASGGKLIFYDL-RGEGVKLQVMANSRNYKSEEEFIHINNKLR 177 Query: 312 AGDVLNLTAKPDRAKR 327 GD++ + P + K+ Sbjct: 178 RGDIIGVQGNPGKTKK 193 >2BK5-A nrPDB Length = 520 Score = 30.6 bits (67), Expect = 2.4, Method: Composition-based stats. Identities = 18/78 (23%), Positives = 29/78 (37%), Gaps = 2/78 (2%) Query: 424 GATIGRYANRISKGKFSLCNKDYQLTVNNGVNANHSSIGSFHRKRFLGPIIQNPSKDVFT 483 G+ +G NRI + L + Y+ VN H G + R P + NP + Sbjct: 58 GSYVGPTQNRILRLAKELGLETYK--VNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDH 115 Query: 484 AEYMLIDNEKDTEFPGDL 501 + ++ E P D Sbjct: 116 NNFWRTMDDMGREIPSDA 133 >2ATV-A nrPDB Length = 196 Score = 30.6 bits (67), Expect = 2.8, Method: Composition-based stats. Identities = 17/87 (19%), Positives = 30/87 (34%), Gaps = 11/87 (12%) Query: 2 TAQLQSESTSKI----VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEV 57 T L +S +K + + G AG S VV + + D T +S R + Sbjct: 15 TENLYFQSMAKSAEVKLAIFGRAGVGKSALVVRFLTKRF-IWEYD----PTLESTYRHQA 69 Query: 58 LTKHHIPFYEVDLCDRKGLEKVFKEYK 84 + +++ D G E + Sbjct: 70 TIDDEV--VSMEILDTAGQEDTIQREG 94 >4G65-A nrPDB Length = 461 Score = 30.2 bits (66), Expect = 2.9, Method: Composition-based stats. Identities = 8/34 (23%), Positives = 15/34 (44%), Gaps = 1/34 (2%) Query: 9 STSKIVLVTGGAGYIGSHTVVELIENGYDCVVAD 42 S + +++ G AG +G L+ D + D Sbjct: 1 SNAMKIIILG-AGQVGGTLAENLVGENNDITIVD 33 >1O5W-A nrPDB Length = 534 Score = 30.2 bits (66), Expect = 3.1, Method: Composition-based stats. Identities = 20/85 (23%), Positives = 30/85 (35%), Gaps = 4/85 (4%) Query: 424 GATIGRYANRISKGKFSLCNKDYQLTVNNG-VNANHSSIGSFHRKRFLGPIIQNPSKDVF 482 GA +G NRI + L + Y++ VN V F R P + NP + Sbjct: 75 GAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPF---RGAFPPVWNPLAYLD 131 Query: 483 TAEYMLIDNEKDTEFPGDLLVTIQY 507 +E E P D ++ Sbjct: 132 YNNLWRTMDEMGKEIPVDAPWQARH 156 >3TTE-A nrPDB Length = 383 Score = 30.2 bits (66), Expect = 3.1, Method: Composition-based stats. Identities = 5/19 (26%), Positives = 7/19 (36%) Query: 2 TAQLQSESTSKIVLVTGGA 20 T L +S +TG Sbjct: 15 TENLYFQSMMTTAAITGVT 33 >4YU5-A nrPDB Length = 756 Score = 30.2 bits (66), Expect = 3.2, Method: Composition-based stats. Identities = 51/340 (15%), Positives = 96/340 (28%), Gaps = 46/340 (13%) Query: 85 IDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFVFSSSATVYGDATR 144 + +H A K + S Y N G + + + + + + G Sbjct: 221 VKEALHAAAEKGLDLSQFDQFDRYDTNSDGNQNEPDGVIDHLM--VIHAGVGQEAGGGKL 278 Query: 145 FPNMIPIPEECPLGPTNPYGHTKYAIENILNDLYNSDKKSWKFAILRYFNPIGAHPSGLI 204 + I +K AI+ + + S YF A I Sbjct: 279 GDDAIWSH------------RSKLAIDPVAIEGTKSKVD--------YFGGKVAAHDYTI 318 Query: 205 GEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDY-IHVVDLAKGHIAALQ 263 + + + A G L D + G+P+ + + G IA + Sbjct: 319 EPEDGAVG------VFAHAFGHDLGLPDEYDTKYTGTGSPVEAWSLMSGGSWTGKIAGTE 372 Query: 264 YLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYK---VTGRRAGDVLNLTA 320 +N+ ++ N+G + Y + G+ R G V Sbjct: 373 PTSFSPQNKDFLQK-NMGGNWAKILEVDYDKIKRGVGVPTYIDQSVTKSNRPGVVRVNLP 431 Query: 321 --KPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGYQLRGVEARFSAE---DMRYDARF 375 + K E T E PF +G A+F + ++ + F Sbjct: 432 GKSVETIKPEFGKHAYYSTRGDDMHT---TLETPFFDLTKGTNAKFDYKANYELEAECDF 488 Query: 376 VTIGA--GTRFQATFANLGASIV---DLKVNGQSVVLGYE 410 V + A + LG +V +G+ + Y+ Sbjct: 489 VEVHAVTEDGTKTLIDRLGEKVVQGDKDTTDGKWIDKSYD 528 >1O89-A nrPDB Length = 345 Score = 30.2 bits (66), Expect = 3.3, Method: Composition-based stats. Identities = 19/75 (25%), Positives = 29/75 (38%), Gaps = 5/75 (6%) Query: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCDR 73 ++VTG +G +GS V L + GY V ++ + F E Sbjct: 171 IVVTGASGGVGSTAVALLHKLGYQVVAVSGRESTHEYLKSLGASRVLPRDEFAE-----S 225 Query: 74 KGLEKVFKEYKIDSV 88 + LEK ID+V Sbjct: 226 RPLEKQVWAGAIDTV 240 >5DBI-A nrPDB Length = 374 Score = 30.2 bits (66), Expect = 3.4, Method: Composition-based stats. Identities = 32/167 (19%), Positives = 55/167 (32%), Gaps = 25/167 (14%) Query: 8 ESTSKIVLVTGGAGYIGSHTVVELI---ENGYDCVVADNLSNSTYDSVARLEVLTKHHIP 64 +S + LV G G +GS L G V +A+ + Sbjct: 1 KSYKSVALVVGVTGIVGSSLAEVLKLPDTPGGPWKVYGVARRPCPVWLAKKP------VE 54 Query: 65 FYEVDLCDRKGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTV-----VLL 119 + + D+ D + E + K + + H + +G NIL +V L Sbjct: 55 YIQCDVSDNQ--ETISKLSPLKDITHIFYVSWIGSEDCQTNATMFKNILNSVIPNASNLQ 112 Query: 120 ELMQQYNVSKF--VFSSSATVYGDATRFPNMIPIPEECP-LGPTNPY 163 + Q + + +F + V P+ P E+ P L N Y Sbjct: 113 HVCLQTGIKHYFGIFEEGSKV------VPHDSPFTEDLPRLNVPNFY 153 >2YV2-A nrPDB Length = 297 Score = 29.8 bits (65), Expect = 4.5, Method: Composition-based stats. Identities = 15/82 (18%), Positives = 22/82 (26%), Gaps = 10/82 (12%) Query: 13 IVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCD 72 VLV G G GS ++E G V EV + L + Sbjct: 15 RVLVQGITGREGSFHAKAMLEYGTKVV------AGVTPGKGGSEVHGVPVYDSVKEALAE 68 Query: 73 RKGLEKVF----KEYKIDSVIH 90 + + D+V Sbjct: 69 HPEINTSIVFVPAPFAPDAVYE 90 >4RZH-A nrPDB Length = 247 Score = 29.8 bits (65), Expect = 4.5, Method: Composition-based stats. Identities = 28/149 (18%), Positives = 61/149 (40%), Gaps = 14/149 (9%) Query: 10 TSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVD 69 T+++ LVTG + IG T + L G VV S++ D+V + + + Sbjct: 5 TAQVALVTGASRGIGKATALALAATGMKVVVNYAQSSTAADAVVAEIIANGGEAIAVQAN 64 Query: 70 LCDRKGLEKVFKE-----YKIDSVIHFAG----LKAVGESTQIPLRYYHNNILG----TV 116 + + ++++ K +ID +++ AG + + N+ G T Sbjct: 65 VANADEVDQLIKTTLDKFSRIDVLVNNAGITRDTLLLRMKLEDWQAVIDLNLTGVFLCTK 124 Query: 117 VLLELMQQYNVSKFVFSSS-ATVYGDATR 144 + +LM + + + +S A + G+ + Sbjct: 125 AVSKLMLKQKSGRIINITSVAGMMGNPGQ 153 >5JS6-A nrPDB Length = 274 Score = 29.4 bits (64), Expect = 5.4, Method: Composition-based stats. Identities = 30/157 (19%), Positives = 51/157 (32%), Gaps = 24/157 (15%) Query: 28 VVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCDRKGLEKVFKE----- 82 V + +G V+ D +S R F D+ ++ + E Sbjct: 28 VRAFVNSGARVVICD-----KDESGGRALEQELPGAVFILCDVTQEDDVKTLVSETIRRF 82 Query: 83 YKIDSVIHFAG-----LKAVGESTQIPLRYYHNNILGTVVLLELMQQY---NVSKFVFSS 134 ++D V++ AG + S Q + N+LGT L +L Y + + S Sbjct: 83 GRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALPYLRKSQGNVINIS 142 Query: 135 S-ATVYGDATRFPNMIPIPEECPLGP-----TNPYGH 165 S G A P + + +PYG Sbjct: 143 SLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGV 179 >4RHL-A nrPDB Length = 351 Score = 29.4 bits (64), Expect = 6.1, Method: Composition-based stats. Identities = 13/69 (18%), Positives = 26/69 (37%) Query: 213 NNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYIHVVDLAKGHIAALQYLEAYNENE 272 N P + + + D G RD +H+++ +G + YN + Sbjct: 234 RNDYPVFISIDADVLDPAFAPAVDSPVAGGLSTRDLLHIMNGIRGPKVVGIDVYGYNPDL 293 Query: 273 GLCREWNLG 281 + R+ N+G Sbjct: 294 DVYRKDNVG 302 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.122 0.304 Lambda K H 0.267 0.0371 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 23,683,451 Number of Sequences: 36641 Number of extensions: 913814 Number of successful extensions: 3707 Number of sequences better than 10.0: 249 Number of HSP's better than 10.0 without gapping: 200 Number of HSP's successfully gapped in prelim test: 134 Number of HSP's that attempted gapping in prelim test: 3129 Number of HSP's gapped (non-prelim): 352 length of query: 699 length of database: 10,336,785 effective HSP length: 104 effective length of query: 595 effective length of database: 6,526,121 effective search space: 3883041995 effective search space used: 3883041995 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 62 (28.6 bits)