BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P04181 (439 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1OAT-A nrPDB 907 0.0 5VIU-A nrPDB 524 e-149 3NTJ-A nrPDB 468 e-132 1Z7D-A nrPDB 456 e-128 5EAV-A nrPDB 426 e-120 3RUY-A nrPDB 404 e-113 2EH6-A nrPDB 245 3e-65 4JF0-A nrPDB 239 1e-63 1WKH-A nrPDB 235 3e-62 2E54-A nrPDB 231 6e-61 3NX3-A nrPDB 215 2e-56 5X3F-A nrPDB 212 3e-55 4ADC-A nrPDB 210 1e-54 1SFF-A nrPDB 196 1e-50 3OKS-A nrPDB 192 3e-49 2EO5-A nrPDB 184 7e-47 4PPM-A nrPDB 181 6e-46 3DOD-A nrPDB 180 9e-46 3R4T-A nrPDB 177 6e-45 6IO1-A nrPDB 173 1e-43 6FYQ-A nrPDB 173 2e-43 3Q8N-A nrPDB 170 1e-42 5LL2-A nrPDB 167 1e-41 5LH9-A nrPDB 155 2e-38 5KR6-A nrPDB 154 6e-38 4FFC-A nrPDB 153 2e-37 3N5M-A nrPDB 153 2e-37 5UC7-A nrPDB 151 5e-37 1ZOD-A nrPDB 151 6e-37 4UHN-A nrPDB 150 1e-36 6ERK-A nrPDB 148 6e-36 3L44-A nrPDB 147 8e-36 5KQW-A nrPDB 146 1e-35 6G4F-A nrPDB 146 2e-35 5KR3-A nrPDB 145 3e-35 5KR5-A nrPDB 145 3e-35 4ATP-A nrPDB 144 1e-34 5GHG-A nrPDB 143 2e-34 6GWI-A nrPDB 142 3e-34 5TI8-A nrPDB 141 6e-34 4BQ0-A nrPDB 140 7e-34 3I4J-A nrPDB 139 3e-33 5KQU-A nrPDB 138 5e-33 5G4J-A nrPDB 134 7e-32 1S09-A nrPDB 132 2e-31 5KQT-A nrPDB 132 3e-31 2CFB-A nrPDB 131 8e-31 3GJU-A nrPDB 130 1e-30 4GRX-A nrPDB 130 1e-30 4BA4-A nrPDB 129 2e-30 5M46-A nrPDB 126 2e-29 4WYG-A nrPDB 126 2e-29 3A8U-X nrPDB 126 2e-29 4GSA-A nrPDB 125 4e-29 3FCR-A nrPDB 123 2e-28 4E3Q-A nrPDB 122 2e-28 3HMU-A nrPDB 122 4e-28 2JJG-A nrPDB 119 2e-27 3K28-A nrPDB 117 9e-27 5HDM-A nrPDB 117 1e-26 3BS8-A nrPDB 115 3e-26 2EPJ-A nrPDB 115 3e-26 2E7U-A nrPDB 115 4e-26 4E77-A nrPDB 114 8e-26 4AOA-A nrPDB 114 1e-25 6GIO-D nrPDB 112 4e-25 5G0A-A nrPDB 108 6e-24 5I92-A nrPDB 107 8e-24 3I5T-A nrPDB 103 1e-22 2ZUK-A nrPDB 103 1e-22 4ZM4-A nrPDB 86 4e-17 5YKR-A nrPDB 80 2e-15 5DDW-A nrPDB 75 5e-14 1OHW-A nrPDB 75 6e-14 2YKV-A nrPDB 72 4e-13 4A0G-A nrPDB 69 4e-12 2CY8-A nrPDB 65 8e-11 6CBN-A nrPDB 42 5e-04 3L8A-A nrPDB 37 0.019 5Z8A-A nrPDB 33 0.25 6M9X-A nrPDB 32 0.39 3DZZ-A nrPDB 32 0.55 2ZTC-A nrPDB 32 0.77 5NRM-A nrPDB 31 1.3 1XRE-A nrPDB 29 3.2 5T51-A nrPDB 29 3.7 4QWV-A nrPDB 28 7.2 >1OAT-A nrPDB Length = 439 Score = 907 bits (2343), Expect = 0.0, Method: Compositional matrix adjust. Identities = 439/439 (100%), Positives = 439/439 (100%) Query: 1 MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPV 60 MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPV Sbjct: 1 MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPV 60 Query: 61 ALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVL 120 ALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVL Sbjct: 61 ALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVL 120 Query: 121 GEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGR 180 GEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGR Sbjct: 121 GEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGR 180 Query: 181 TLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVV 240 TLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVV Sbjct: 181 TLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVV 240 Query: 241 PDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYP 300 PDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYP Sbjct: 241 PDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYP 300 Query: 301 VSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNEL 360 VSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNEL Sbjct: 301 VSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNEL 360 Query: 361 MKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVI 420 MKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVI Sbjct: 361 MKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVI 420 Query: 421 KEDELRESIEIINKTILSF 439 KEDELRESIEIINKTILSF Sbjct: 421 KEDELRESIEIINKTILSF 439 >5VIU-A nrPDB Length = 419 Score = 524 bits (1349), Expect = e-149, Method: Compositional matrix adjust. Identities = 251/406 (61%), Positives = 316/406 (77%), Gaps = 5/406 (1%) Query: 39 TSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIV 98 S+ E E K+GAHNYHPLPV L+RG+G+++WDVEG+KY+DFLS+YSAVNQGH HPKIV Sbjct: 14 NSEYFIELEEKHGAHNYHPLPVVLDRGEGVFVWDVEGKKYYDFLSAYSAVNQGHSHPKIV 73 Query: 99 NALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGY 158 AL Q KL LTSRAFYN+ LGEYE+ IT L + KVLPMN+G EA ETA KLARKW Y Sbjct: 74 EALVEQASKLALTSRAFYNSKLGEYEQKITSLLGFDKVLPMNSGAEAVETAVKLARKWSY 133 Query: 159 TVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERA 218 VKGI + AKI+ NF GRT + +S S DP + +GPF PGF IPYND+ ALE Sbjct: 134 EVKGIAENAAKIIVCENNFHGRTTTIVSFSNDPDANQNYGPFTPGFIRIPYNDIAALEEV 193 Query: 219 LQDP--NVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWL 276 L N+AAF+VEPIQGEAGV VP+ G+L ELC +H VLFIADE+QTG+ARTG+ + Sbjct: 194 LSKEAGNIAAFLVEPIQGEAGVYVPNEGFLKQSSELCKKHNVLFIADEVQTGIARTGKLI 253 Query: 277 AVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAA 336 A +E+V+PDI++LGKALSGG+YPVSAVL +++IM IKPG+HGST+GGNPL C VA+AA Sbjct: 254 ACHHEDVQPDILILGKALSGGMYPVSAVLANNNIMDVIKPGQHGSTFGGNPLACAVAMAA 313 Query: 337 LEVLEEENLAENADKLGIILRNELMKL--PSDVVTAVRGKGLLNAIVIKETKDWD-AWKV 393 L+V+++E L+E A+KLG + R+E+ KL +D++T VRGKGLLNAI+I +T D AW + Sbjct: 314 LDVVQDEKLSERAEKLGNLFRSEIEKLIEKTDLITKVRGKGLLNAILINDTPDSSTAWNL 373 Query: 394 CLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF 439 CL L++NGLLAKPTHG+IIR APPLVI E++L + ++II KTIL F Sbjct: 374 CLALKENGLLAKPTHGNIIRLAPPLVITEEQLLDCVKIIEKTILEF 419 >3NTJ-A nrPDB Length = 422 Score = 468 bits (1203), Expect = e-132, Method: Compositional matrix adjust. Identities = 224/403 (55%), Positives = 287/403 (71%), Gaps = 3/403 (0%) Query: 39 TSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIV 98 +S D E YGAHNY P+PV L+RGKG++++D+E R+Y+DFLS+YS+VNQGHCHP I+ Sbjct: 9 SSQDYMNNELTYGAHNYDPIPVVLKRGKGVFVYDIEDRRYYDFLSAYSSVNQGHCHPDIL 68 Query: 99 NALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGY 158 NA+ +Q KLT+ SRAF+++ LG E Y+T LF Y KVL MNTG EA ETA KL RKWGY Sbjct: 69 NAMINQAKKLTICSRAFFSDSLGVCERYLTNLFGYDKVLMMNTGAEASETAYKLCRKWGY 128 Query: 159 TVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERA 218 VK I + AKI+ NF GRTL +S+STD + FGPF+P F +PY+DL ALE+ Sbjct: 129 EVKKIPENSAKIIVCNNNFSGRTLGCVSASTDKKCKNNFGPFVPNFLKVPYDDLEALEKE 188 Query: 219 LQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAV 278 LQDPNV AF+VEP+QGEAGV+VP Y GV LC ++ VLF+ADE+QTGL RTG+ L Sbjct: 189 LQDPNVCAFIVEPVQGEAGVIVPSDSYFPGVASLCKKYNVLFVADEVQTGLGRTGKLLCT 248 Query: 279 DYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALE 338 + V+PD++LLGKALSGG YP+SA+L +DD+ML +KPGEHGSTYGGNPL + + AL+ Sbjct: 249 HHYGVKPDVILLGKALSGGHYPISAILANDDVMLVLKPGEHGSTYGGNPLAAAICVEALK 308 Query: 339 VLEEENLAENADKLGI-ILRNELMKLP-SDVVTAVRGKGLLNAIVIKETKDWDAWKVCLR 396 VL E L ENADKLG L+N +L S VV VRGKGLL AI K + W +CL+ Sbjct: 309 VLINEKLCENADKLGAPFLQNLKEQLKDSKVVREVRGKGLLCAIEFKNDL-VNVWDICLK 367 Query: 397 LRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF 439 ++NGL+ + H +R PPL I +++L E EII KT+ F Sbjct: 368 FKENGLITRSVHDKTVRLTPPLCITKEQLDECTEIIVKTVKFF 410 >1Z7D-A nrPDB Length = 433 Score = 456 bits (1172), Expect = e-128, Method: Compositional matrix adjust. Identities = 227/408 (55%), Positives = 284/408 (69%), Gaps = 3/408 (0%) Query: 34 VQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHC 93 V+ T +D E KYGAHNY P+PV L+R KG++++DV ++Y+DFLS+YS+VNQGHC Sbjct: 23 VKDLKTPEDYINNELKYGAHNYDPIPVVLKRAKGVFVYDVNDKRYYDFLSAYSSVNQGHC 82 Query: 94 HPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLA 153 HP I+NA+ +Q LT+ SRAF++ LG E Y+T L Y KVL MNTG EA ETA KL Sbjct: 83 HPNILNAMINQAKNLTICSRAFFSVPLGICERYLTNLLGYDKVLMMNTGAEANETAYKLC 142 Query: 154 RKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLP 213 RKWGY VK I + AKIV NF GRTL IS+ST FGPF P F +PY+DL Sbjct: 143 RKWGYEVKKIPENMAKIVVCKNNFSGRTLGCISASTTKKCTSNFGPFAPQFSKVPYDDLE 202 Query: 214 ALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTG 273 ALE L+DPNV AF+VEPIQGEAGV+VP YL GV ++C ++ VLF+ADE+QTGL RTG Sbjct: 203 ALEEELKDPNVCAFIVEPIQGEAGVIVPSDNYLQGVYDICKKYNVLFVADEVQTGLGRTG 262 Query: 274 RWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVA 333 + L V + NV+PD++LLGKALSGG YP+SAVL +DDIML IKPGEHGSTYGGNPL + Sbjct: 263 KLLCVHHYNVKPDVILLGKALSGGHYPISAVLANDDIMLVIKPGEHGSTYGGNPLAASIC 322 Query: 334 IAALEVLEEENLAENADKL-GIILRNELMKLP-SDVVTAVRGKGLLNAIVIKETKDWDAW 391 + AL VL E L ENA+KL G L N +L S +V VRGKGLL AI K + + Sbjct: 323 VEALNVLINEKLCENAEKLGGPFLENLKRELKDSKIVRDVRGKGLLCAIEFK-NELVNVL 381 Query: 392 KVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF 439 +CL+L++NGL+ + H IR PPL I +++L E EII KT+ F Sbjct: 382 DICLKLKENGLITRDVHDKTIRLTPPLCITKEQLDECTEIIVKTVKFF 429 >5EAV-A nrPDB Length = 441 Score = 426 bits (1096), Expect = e-120, Method: Compositional matrix adjust. Identities = 208/405 (51%), Positives = 284/405 (70%), Gaps = 8/405 (1%) Query: 39 TSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIV 98 T +D F + +Y NY P+PV + +GKG +WD+ G +Y+DFL+ S+++QGHCHP+++ Sbjct: 33 TEEDFFACDRQYVCQNYAPVPVVISKGKGARVWDINGNEYYDFLAGVSSLSQGHCHPRVI 92 Query: 99 NALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGY 158 AL Q ++LTLT RAF N+V G ++ ++F Y +VL MNTG EAGE+A K+ARKW Y Sbjct: 93 AALCRQAERLTLTLRAFGNDVTGPACRFMAEMFGYDRVLLMNTGAEAGESALKIARKWAY 152 Query: 159 TVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERA 218 VK I AK++ N+WGRT++A SSST Y+ FGPF PGF++I Y+D+ ALE A Sbjct: 153 EVKEIPPDSAKVILCNNNYWGRTITACSSSTTFDCYNNFGPFTPGFELIDYDDVGALEEA 212 Query: 219 LQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAV 278 L+DPNVAAF VEPIQGE GV VP PGYL ELC VL I DEIQTGL RTGR LA Sbjct: 213 LKDPNVAAFFVEPIQGEGGVNVPKPGYLKRAHELCRSKNVLLIVDEIQTGLCRTGRLLAA 272 Query: 279 DYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALE 338 D++ V PDI+LLGK+LS G+ P+SAV+ D+M +KPG HGST+GGNPL C VA+ AL Sbjct: 273 DHDEVHPDILLLGKSLSAGVVPISAVMGRADVMDVLKPGTHGSTFGGNPLACAVAVEALT 332 Query: 339 VLEEENLAENADKLGI----ILRNELM-KLPSDVVTAVRGKGLLNAIVIKETKDWDAWKV 393 VL++E LA+ A++LG LR EL K+P + +RG+GLLNA+ + ++ D V Sbjct: 333 VLKDEKLADRAERLGAQFRDCLRRELYGKVPW--IKEIRGRGLLNAVEV-DSDAIDPNDV 389 Query: 394 CLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILS 438 ++L++NG+L+KPT G ++RF PPLVI ++E R++ I K+ L+ Sbjct: 390 VMKLKENGILSKPTRGRVMRFIPPLVITDEEHRDATTRIIKSFLA 434 >3RUY-A nrPDB Length = 392 Score = 404 bits (1039), Expect = e-113, Method: Compositional matrix adjust. Identities = 202/397 (50%), Positives = 274/397 (69%), Gaps = 6/397 (1%) Query: 42 DIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNAL 101 DI E YGA+NYHPLP+ + + +G+++ D EG +Y D LS+YSAVNQGH HPKI+NAL Sbjct: 2 DIIELTDTYGANNYHPLPIVISKAEGVWVEDPEGNRYMDLLSAYSAVNQGHRHPKIINAL 61 Query: 102 KSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVK 161 Q +++TLTSRAF+++ LG + E + KL N VLPMNTG EA ETA K AR+W Y VK Sbjct: 62 IDQANRVTLTSRAFHSDQLGPWYEKVAKLTNKEMVLPMNTGAEAVETAIKTARRWAYDVK 121 Query: 162 GIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQD 221 ++ +A+I+ NF GRT+ A+S S++ GFGP +PG +IPY DL AL+ A+ Sbjct: 122 KVEANRAEIIVCEDNFHGRTMGAVSMSSNEEYKRGFGPMLPGIIVIPYGDLEALKAAIT- 180 Query: 222 PNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYE 281 PN AAF++EPIQGEAG+ +P G+L E+C + VLF+ADEIQTGL RTG+ A D++ Sbjct: 181 PNTAAFILEPIQGEAGINIPPAGFLKEALEVCKKENVLFVADEIQTGLGRTGKVFACDWD 240 Query: 282 NVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLE 341 NV PD+ +LGKAL GG++P+S + DI+ +PG HGST+GGNPL C V+IAALEVLE Sbjct: 241 NVTPDMYILGKALGGGVFPISCAAANRDILGVFEPGSHGSTFGGNPLACAVSIAALEVLE 300 Query: 342 EENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNG 401 EE L E + +LG L +L ++ + ++T VRGKGL I + E A C +L+ G Sbjct: 301 EEKLTERSLQLGEKLVGQLKEIDNPMITEVRGKGLFIGIELNEP----ARPYCEQLKAAG 356 Query: 402 LLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILS 438 LL K TH ++IR APPLVI E++L + + I K +LS Sbjct: 357 LLCKETHENVIRIAPPLVISEEDLEWAFQKI-KAVLS 392 >2EH6-A nrPDB Length = 375 Score = 245 bits (625), Expect = 3e-65, Method: Compositional matrix adjust. Identities = 141/389 (36%), Positives = 220/389 (56%), Gaps = 17/389 (4%) Query: 50 YGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLT 109 Y +NY LPV RGKG+YL+D EG++Y DF+S + GH +PK+ ALK QV+KL Sbjct: 2 YLMNNYARLPVKFVRGKGVYLYDEEGKEYLDFVSGIGVNSLGHAYPKLTEALKEQVEKLL 61 Query: 110 LTSRAFYNNVLGEYEEYITKLF-NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKA 168 S + N E + K F KV N+G E+ E A KLARK+ + KG K K Sbjct: 62 HVSNLYENPWQEELAHKLVKHFWTEGKVFFANSGTESVEAAIKLARKY-WRDKG--KNKW 118 Query: 169 KIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFM 228 K + +F GRT ++S++ P + GF P +PGF ND+ ++ + L D A + Sbjct: 119 KFISFENSFHGRTYGSLSATGQPKFHKGFEPLVPGFSYAKLNDIDSVYKLL-DEETAGII 177 Query: 229 VEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIV 288 +E IQGE GV +L ++E+C VL I DE+QTG+ RTG + A + N++PD++ Sbjct: 178 IEVIQGEGGVNEASEDFLSKLQEICKEKDVLLIIDEVQTGIGRTGEFYAYQHFNLKPDVI 237 Query: 289 LLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAEN 348 L K L GG+ P+ A+L +++ + PG HGST+GGNPL CR ++ E E L + Sbjct: 238 ALAKGLGGGV-PIGAILAREEVAQSFTPGSHGSTFGGNPLACRAGTVVVD--EVEKLLPH 294 Query: 349 ADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVI-KETKDWDAWKVCLRLRDNGLLAKPT 407 ++G + +L +L V+G+GL+ + + +E KD+ L+ + GLL T Sbjct: 295 VREVGNYFKEKLKELGKG---KVKGRGLMLGLELERECKDY-----VLKALEKGLLINCT 346 Query: 408 HGDIIRFAPPLVIKEDELRESIEIINKTI 436 G ++RF PPL+I+++ + +I ++ + + Sbjct: 347 AGKVLRFLPPLIIQKEHIDRAISVLREIL 375 >4JF0-A nrPDB Length = 422 Score = 239 bits (611), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 145/414 (35%), Positives = 211/414 (50%), Gaps = 13/414 (3%) Query: 25 ATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSS 84 A+ +AT++T T D++ Y P +GKG +WD +G++Y DF Sbjct: 13 ASHMATEQTAITRATFDEVILPVYA-------PADFIPVKGKGSRVWDQQGKEYIDFAGG 65 Query: 85 YSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVE 144 + GHCHP +V ALKSQ + L TSR F N + +VL MN+G E Sbjct: 66 IAVTALGHCHPALVEALKSQGETLWHTSRVFTNEPALRLGRKLIDATFAERVLFMNSGTE 125 Query: 145 AGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGF 204 A ETA KLAR Y +K KI+ F GR+L +S P DGFGP Sbjct: 126 ANETAFKLARH--YACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADI 183 Query: 205 DIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADE 264 +P+NDL A+ +A+ D + A +VEPIQGE GV P +L G+R+LC HQ L + DE Sbjct: 184 IHVPFNDLHAV-KAVMDDHTCAVVVEPIQGEGGVQAATPEFLKGLRDLCDEHQALLVFDE 242 Query: 265 IQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYG 324 +Q G+ RTG A + V PDI+ KAL GG +PVSA+L +I G HGSTYG Sbjct: 243 VQCGMGRTGDLFAYMHYGVTPDILTSAKALGGG-FPVSAMLTTQEIASAFHVGSHGSTYG 301 Query: 325 GNPLGCRVAIAALEVLEEENLAE--NADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVI 382 GNPL C VA A +++ + + + + + + + D+ + +RG GLL + Sbjct: 302 GNPLACAVAGATFDIINTPEVLQGIHTKRQQFVQHLQAIDEQFDIFSDIRGMGLLIGAEL 361 Query: 383 KETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTI 436 K A + G++ D++RFAP LV++E ++ E ++ + + Sbjct: 362 KPKYKGRARDFLYAGAEAGVMVLNAGADVMRFAPSLVVEEADIHEGMQRFAQAV 415 >1WKH-A nrPDB Length = 395 Score = 235 bits (599), Expect = 3e-62, Method: Compositional matrix adjust. Identities = 137/394 (34%), Positives = 210/394 (53%), Gaps = 17/394 (4%) Query: 45 EREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQ 104 E+ G +N H L + RG+G +WD EG +Y D + Y N GH +P++V A+K Q Sbjct: 16 EKTLDSGVYNKHDLLIV--RGQGARVWDAEGNEYIDCVGGYGVANLGHGNPEVVEAVKRQ 73 Query: 105 VDKLTLTSRAFYNNVLGEYEEYITKLF--NYHKVLPMNTGVEAGETACKLARKWGYTVKG 162 + L + + GE+ +T + ++V P+N+G EA E A K AR Sbjct: 74 AETLMAMPQTLPTPMRGEFYRTLTAILPPELNRVFPVNSGTEANEAALKFARA------- 126 Query: 163 IQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDP 222 + K V A F GRT+ ++S + +P + F P + + IPYND+ AL+RA+ D Sbjct: 127 -HTGRKKFVAAMRGFSGRTMGSLSVTWEPKYREPFLPLVEPVEFIPYNDVEALKRAV-DE 184 Query: 223 NVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYEN 282 AA ++EP+QGE GV P +L RE+ L I DEIQTG+ RTG+ A ++ Sbjct: 185 ETAAVILEPVQGEGGVRPATPEFLRAAREITQEKGALLILDEIQTGMGRTGKRFAFEHFG 244 Query: 283 VRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEE 342 + PDI+ L KAL GG+ P+ + +++ ++ G HG+T+GGNPL +AA+ LE Sbjct: 245 IVPDILTLAKALGGGV-PLGVAVMREEVARSMPKGGHGTTFGGNPLAMAAGVAAIRYLER 303 Query: 343 ENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGL 402 L E A +LG +L +PS + VRG GL+ + +KE ++ R L Sbjct: 304 TRLWERAAELGPWFMEKLRAIPSPKIREVRGMGLMVGLELKEKAAPYIARLEKEHRVLAL 363 Query: 403 LAKPTHGDIIRFAPPLVIKEDELRESIEIINKTI 436 A PT +IRF PPLVI++++L +E + + Sbjct: 364 QAGPT---VIRFLPPLVIEKEDLERVVEAVRAVL 394 >2E54-A nrPDB Length = 385 Score = 231 bits (588), Expect = 6e-61, Method: Compositional matrix adjust. Identities = 136/389 (34%), Positives = 211/389 (54%), Gaps = 10/389 (2%) Query: 50 YGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLT 109 Y + Y P GKG +++D +G Y DF S + GH HP++V A+K Q +KL Sbjct: 2 YLMNTYSRFPATFVYGKGSWIYDEKGNAYLDFTSGIAVNVLGHSHPRLVEAIKDQAEKLI 61 Query: 110 LTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAK 169 S F+N E E ++K KV NTG EA E A K+ARK K + K + Sbjct: 62 HCSNLFWNRPQMELAELLSKNTFGGKVFFANTGTEANEAAIKIARK---YGKKKSEKKYR 118 Query: 170 IVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMV 229 I+ A +F GRTL +++++ P F P +PGF+ +N++ L R + + +V A + Sbjct: 119 ILSAHNSFHGRTLGSLTATGQPKYQKPFEPLVPGFEYFEFNNVEDLRRKMSE-DVCAVFL 177 Query: 230 EPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVL 289 EPIQGE+G+V +L R+LC + L + DE+Q G+ RTG+ A V PD++ Sbjct: 178 EPIQGESGIVPATKEFLEEARKLCDEYDALLVFDEVQCGMGRTGKLFAYQKYGVVPDVLT 237 Query: 290 LGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENA 349 K L GG+ P+ AV+ ++ + ++PG+HG+T+GGNPL CR + ++ L +E E Sbjct: 238 TAKGLGGGV-PIGAVIVNERANV-LEPGDHGTTFGGNPLACRAGVTVIKELTKEGFLEEV 295 Query: 350 DKLGIILRNEL--MKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPT 407 ++ G L +L MK DVV VRG GL+ I +E + +V + +N LL P Sbjct: 296 EEKGNYLMKKLQEMKEEYDVVADVRGMGLMIGIQFRE--EVSNREVATKCFENKLLVVPA 353 Query: 408 HGDIIRFAPPLVIKEDELRESIEIINKTI 436 + IRF PPL ++ E+ ++E + K + Sbjct: 354 GNNTIRFLPPLTVEYGEIDLAVETLKKVL 382 >3NX3-A nrPDB Length = 395 Score = 215 bits (548), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 128/398 (32%), Positives = 209/398 (52%), Gaps = 11/398 (2%) Query: 47 EYKYGAH---NYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKS 103 +YK +H Y + LE+G+G+YL+D + +KY DF S G+ H K +K+ Sbjct: 4 DYKEQSHIIPTYKRFDIVLEKGQGVYLFDDKAKKYLDFSSGIGVCALGYNHAKFNAKIKA 63 Query: 104 QVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGI 163 QVDKL TS +YN + + + K +V N+G E+ E A K ARK+ + KG+ Sbjct: 64 QVDKLLHTSNLYYNENIAAAAKNLAKASALERVFFTNSGTESIEGAMKTARKYAFN-KGV 122 Query: 164 QKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPN 223 + + + +F GRTL A+S + + F P + G YND+ ++E+ L + Sbjct: 123 K--GGQFIAFKHSFHGRTLGALSLTANEKYQKPFKPLISGVKFAKYNDISSVEK-LVNEK 179 Query: 224 VAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENV 283 A ++E +QGE G+ + + +R+LC +L IADEIQ G+ R+G++ A ++ + Sbjct: 180 TCAIILESVQGEGGINPANKDFYKALRKLCDEKDILLIADEIQCGMGRSGKFFAYEHAQI 239 Query: 284 RPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEE 343 PDI+ KAL GL + V+ +++ G+HGSTYGGNPL C A E+ +EE Sbjct: 240 LPDIMTSAKALGCGLSVGAFVINQKVASNSLEAGDHGSTYGGNPLVCAGVNAVFEIFKEE 299 Query: 344 NLAENADKLGIILRNELMKLPS--DVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNG 401 + EN +KL L L +L + D +G G + + + K KV + ++N Sbjct: 300 KILENVNKLTPYLEQSLDELINEFDFCKKRKGLGFMQGLSL--DKSVKVAKVIQKCQENA 357 Query: 402 LLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF 439 LL + +RF PPL+++++ + E E + K + SF Sbjct: 358 LLLISCGENDLRFLPPLILQKEHIDEMSEKLRKALKSF 395 >5X3F-A nrPDB Length = 501 Score = 212 bits (539), Expect = 3e-55, Method: Compositional matrix adjust. Identities = 129/384 (33%), Positives = 207/384 (53%), Gaps = 27/384 (7%) Query: 70 LWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITK 129 L D +G+++ D L + N GH +P +V+A+++Q+ K L S+ + + + + Sbjct: 74 LVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVQNQLAKQPLHSQELLDPLRAMLAKTLAA 133 Query: 130 LF--NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAA--GNFWGRTLSAI 185 L N+G E+ E A KLA+ + Q + K F A G F G++L A+ Sbjct: 134 LTPGKLKYSFFCNSGTESVEAALKLAKAY-------QSPRGKFTFIATSGAFHGKSLGAL 186 Query: 186 SSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQD-----PNVAAFMVEPIQGEAGVVV 240 S++ T F P +PGF +P+ ++ A+ AL + +VAA ++EPIQGE GV++ Sbjct: 187 SATAKSTFRKPFMPLLPGFRHVPFGNIEAMRTALNECKKTGDDVAAVILEPIQGEGGVIL 246 Query: 241 PDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYP 300 P PGYL VR+LC L I DE+QTG+ RTG+ A ++ENV+PDI+ L KAL GG+ P Sbjct: 247 PPPGYLTAVRKLCDEFGALMILDEVQTGMGRTGKMFACEHENVQPDILCLAKALGGGVMP 306 Query: 301 VSAVLCDDDI--MLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRN 358 + A + +++ +L P H +T+GGNPL C A+A + VL E+NL A++ G +L + Sbjct: 307 IGATIATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLLEQNLPAQAEQKGDMLLD 366 Query: 359 ELMKLPS---DVVTAVRGKGLLNAIVIKETK---DWDAWKVCLRLRDNGLLAKPTHGDII 412 +L D+V RGKG+L AI + + ++ + R+ G L + I Sbjct: 367 GFRQLAREYPDLVQEARGKGMLMAIEFVDNEIGYNFASEMFRQRVLVAGTL---NNAKTI 423 Query: 413 RFAPPLVIKEDELRESIEIINKTI 436 R PPL + ++ I+ K + Sbjct: 424 RIEPPLTLTIEQCELVIKAARKAL 447 >4ADC-A nrPDB Length = 406 Score = 210 bits (534), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 132/379 (34%), Positives = 188/379 (49%), Gaps = 8/379 (2%) Query: 55 YHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRA 114 Y P P RG+G LWD +G++Y DF + GH HP++ AL Q K T Sbjct: 18 YAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNG 77 Query: 115 FYNN-VLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFA 173 + N VL ++ I F +V N+G EA E A KLARK+ + G +K+ IV Sbjct: 78 YTNEPVLRLAKKLIDATF-ADRVFFCNSGAEANEAALKLARKFAHDRYG--SHKSGIVAF 134 Query: 174 AGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQ 233 F GRTL +S+ P F P YND+ + AL D + A +VEPIQ Sbjct: 135 KNAFHGRTLFTVSAGGQPAYSQDFAPLPADIRHAAYNDINSAS-ALIDDSTCAVIVEPIQ 193 Query: 234 GEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKA 293 GE GVV +L G+RELC RH L I DE+QTG+ RTG A + V PD++ KA Sbjct: 194 GEGGVVPASNAFLQGLRELCNRHNALLIFDEVQTGVGRTGELYAYMHYGVTPDLLTTAKA 253 Query: 294 LSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLG 353 L GG +PV A+L ++ + G HG+TYGGNPL VA LE++ + + Sbjct: 254 LGGG-FPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRH 312 Query: 354 --IILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDI 411 + R + + + VRG GLL V+ A ++ G++ G++ Sbjct: 313 DWFVERLNTINHRYGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNV 372 Query: 412 IRFAPPLVIKEDELRESIE 430 +RFAP L + E+E+ ++ Sbjct: 373 VRFAPALNVSEEEVTTGLD 391 >1SFF-A nrPDB Length = 426 Score = 196 bits (499), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 128/410 (31%), Positives = 210/410 (51%), Gaps = 48/410 (11%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNN 118 P+ +R + +WDVEGR+Y DF + +N GH HPK+V A+++Q+ KL+ T Sbjct: 24 PIFADRAENCRVWDVEGREYLDFAGGIAVLNTGHLHPKVVAAVEAQLKKLSHTCF----Q 79 Query: 119 VLGEYEEYI--TKLFNYH-------KVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAK 169 VL YE Y+ ++ N K L + TG EA E A K+AR K Sbjct: 80 VLA-YEPYLELCEIMNQKVPGDFAKKTLLVTTGSEAVENAVKIARAA-------TKRSGT 131 Query: 170 IVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGF-----------DIIPYNDLPALERA 218 I F+ G + GRT ++ + Y MPG I + + ++ R Sbjct: 132 IAFS-GAYHGRTHYTLALTGKVNPYSAGMGLMPGHVYRALYPCPLHGISEDDAIASIHRI 190 Query: 219 LQD----PNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGR 274 ++ ++AA ++EP+QGE G P ++ +R LC H ++ IADE+Q+G RTG Sbjct: 191 FKNDAAPEDIAAIVIEPVQGEGGFYASSPAFMQRLRALCDEHGIMLIADEVQSGAGRTGT 250 Query: 275 WLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAI 334 A++ V PD+ K+++GG +P++ V ++M + PG G TY GNP+ C A+ Sbjct: 251 LFAMEQMGVAPDLTTFAKSIAGG-FPLAGVTGRAEVMDAVAPGGLGGTYAGNPIACVAAL 309 Query: 335 AALEVLEEENLAENADKLGIILRNELMKLPSD--VVTAVRGKGLLNAIVIKETKDWD--- 389 L+V E+ENL + A+ LG L++ L+ + + VRG G + AI + E D + Sbjct: 310 EVLKVFEQENLLQKANDLGQKLKDGLLAIAEKHPEIGDVRGLGAMIAIELFEDGDHNKPD 369 Query: 390 ---AWKVCLRLRDNG--LLAKPTHGDIIRFAPPLVIKEDELRESIEIINK 434 ++ R RD G LL+ + +++R PL I++ ++R+ +EII++ Sbjct: 370 AKLTAEIVARARDKGLILLSCGPYYNVLRILVPLTIEDAQIRQGLEIISQ 419 >3OKS-A nrPDB Length = 451 Score = 192 bits (487), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 132/420 (31%), Positives = 215/420 (51%), Gaps = 55/420 (13%) Query: 58 LPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYN 117 +PV R G + DV+G + D S + G+ PK+V A++SQV T T Sbjct: 43 MPVYAVRAGGGIVEDVDGNRLIDLGSGIAVTTVGNSAPKVVEAVRSQVGDFTHTC----- 97 Query: 118 NVLGEYEEYITKLFNYHKVLPM---------NTGVEAGETACKLARKWGYTVKGIQKYKA 168 ++ YE Y+ +++ P+ N+G EA E A K+AR +K Sbjct: 98 FMVTPYEGYVAVCEQLNRLTPVRGDKRSALFNSGSEAVENAVKIARS--------HTHKP 149 Query: 169 KIVFAAGNFWGRTLSAISSSTDPTSY-DGFGPFMP----------------GFDIIPYND 211 +V + GRT ++ + Y DGFGPF P G ++ + Sbjct: 150 AVVAFDHAYHGRTNLTMALTAKVMPYKDGFGPFAPEIYRAPLSYPFRDAEFGKELATDGE 209 Query: 212 LPA------LERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEI 265 L A +++ + N+AA ++EPIQGE G +VP G+L + + C ++ V+FIADE+ Sbjct: 210 LAAKRAITVIDKQIGADNLAAVVIEPIQGEGGFIVPADGFLPTLLDWCRKNDVVFIADEV 269 Query: 266 QTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGG 325 QTG ARTG A ++E + PD+++ K ++GGL P+SAV +IM + G TYGG Sbjct: 270 QTGFARTGAMFACEHEGIDPDLIVTAKGIAGGL-PLSAVTGRAEIMDSPHVSGLGGTYGG 328 Query: 326 NPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPS--DVVTAVRGKGLLNA--IV 381 NP+ C A+A +E +E E L A ++ I+++ L +L + D + VRG+G + A +V Sbjct: 329 NPIACAAALATIETIESEGLVARAQQIEKIMKDRLGRLQAEDDRIGDVRGRGAMIAMELV 388 Query: 382 IKETKDWDA---WKVCLRLRDNG--LLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTI 436 T + DA +C G +L+ T+G+++RF PPL I +D L E ++++ + + Sbjct: 389 KAGTTEPDADLTKALCAGAHAAGVIVLSCGTYGNVVRFLPPLSIGDDLLNEGLDVLEEVL 448 >2EO5-A nrPDB Length = 419 Score = 184 bits (467), Expect = 7e-47, Method: Compositional matrix adjust. Identities = 128/413 (30%), Positives = 198/413 (47%), Gaps = 55/413 (13%) Query: 58 LPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQG-HCHPKIVNALKSQVDKLTLTSRAFY 116 P+ ++ G+G++++DV+G KY DF S N G HP+++ Q+ KL + + Sbjct: 24 FPLVIDHGEGVWIYDVDGNKYLDFTSGIGVNNLGWPSHPEVIKIGIEQMQKLAHAAANDF 83 Query: 117 NNVLGEYEEYITKLFNY------HKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKI 170 N+ E KL Y KV N+G EA E + K+ + G +KY I Sbjct: 84 YNI--PQLELAKKLVTYSPGNFQKKVFFSNSGTEAIEASIKVVKNTG------RKY---I 132 Query: 171 VFAAGNFWGRTLSAIS-SSTDPTSYDGFGPFMPGFDIIPY--------------NDLPAL 215 + G F GRT +IS +++ GPFMPG +PY N + Sbjct: 133 IAFLGGFHGRTFGSISLTASKAVQRSIVGPFMPGVIHVPYPNPYRNPWHINGYENPSELV 192 Query: 216 ERALQ------------DPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIAD 263 R ++ VA EPIQGE G V+P + +++L ++ +L + D Sbjct: 193 NRVIEFIEDYIFVNLVPPEEVAGIFFEPIQGEGGYVIPPKNFFAELQKLAKKYGILLVDD 252 Query: 264 EIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTY 323 E+Q GL RTG+ A++ N PD++ L KAL GG+ P+ A + D L KPG H +T+ Sbjct: 253 EVQMGLGRTGKLFAIENFNTVPDVITLAKALGGGIMPIGATIFRKD--LDFKPGMHSNTF 310 Query: 324 GGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIK 383 GGN L C + ++++++ L + +++G I EL L D VRG GL + Sbjct: 311 GGNALACAIGSKVIDIVKD--LLPHVNEIGKIFAEELQGLADD----VRGIGLAWGLEYN 364 Query: 384 ETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTI 436 E K D ++ GLL P IR PPLVI E+E ++ ++I+ K I Sbjct: 365 EKKVRD--RIIGESFKRGLLLLPAGRSAIRVIPPLVISEEEAKQGLDILKKVI 415 >4PPM-A nrPDB Length = 861 Score = 181 bits (459), Expect = 6e-46, Method: Compositional matrix adjust. Identities = 117/364 (32%), Positives = 184/364 (50%), Gaps = 33/364 (9%) Query: 38 PTSDDIFEREYKYGAHNYHPLPV---ALER-------GKGIYLWDVEGRKYFDFLSSYSA 87 P +D +R ++Y +P+ V L+R G L+D G + D ++ Y Sbjct: 389 PAREDTLDRYHQY----INPMMVDFLKLQRCDNVFRSAAGTQLYDDAGEAFLDMVAGYGC 444 Query: 88 VNQGHCHPKIVNALKSQVDKLTLTSRAFYN--NVLGEYEEYITKLF--NYHKVLPMNTGV 143 +N GH +VNALK+ +D + + + E + +L N +V N+G Sbjct: 445 LNLGHNPQPVVNALKNYLDAQGPNFIQYISIPEQTAKLAEVLCRLAPGNMGRVFFSNSGT 504 Query: 144 EAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPG 203 EA E A K+A+ K I + ++ G+TL A+S + F P + Sbjct: 505 EAVEAAMKIAKA--------STGKPGIAYLRNSYHGKTLGALSITGRDKHRRYFTPLLDA 556 Query: 204 FDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIAD 263 +P+ DL AL AL +V A M+EPIQGE GV +P GYL V++LC VL + D Sbjct: 557 MVEVPFGDLAALREALNREDVGALMIEPIQGEGGVHIPPAGYLQAVQQLCRETGVLLMVD 616 Query: 264 EIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE----- 318 E+QTGL RTG+ A +++ + PD+++L K+LSGGL P+ A LC D+ Sbjct: 617 EVQTGLGRTGKLFACEWDGIEPDVLMLSKSLSGGLIPIGATLCRADLWQKAYGTADRFLV 676 Query: 319 HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSD--VVTAVRGKGL 376 H STYGG L VA++AL + ++L +A+++G + L ++ + V+ VRG+GL Sbjct: 677 HSSTYGGGNLASVVALSALREILAQDLVGHAERMGAYFKQALSEIAARYPFVSEVRGRGL 736 Query: 377 LNAI 380 + I Sbjct: 737 MLGI 740 >3DOD-A nrPDB Length = 448 Score = 180 bits (457), Expect = 9e-46, Method: Compositional matrix adjust. Identities = 134/427 (31%), Positives = 216/427 (50%), Gaps = 52/427 (12%) Query: 54 NYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSR 113 +Y P+ +E G GI + D+ G++Y+D SS GH ++ +A+K Q+ K+ ++ Sbjct: 22 DYDENPLIIESGTGIKVKDINGKEYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTL 81 Query: 114 AFYNNV-LGEYEEYITKLF--NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKI 170 NV + E + + +V ++G EA E A K+A ++ + + K K Sbjct: 82 LGMTNVPATQLAETLIDISPKKLTRVFYSDSGAEAMEIALKMAFQYWKNIG--KPEKQKF 139 Query: 171 VFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDI----IPY--------------NDL 212 + + G T+ A+S + + +GP M F+ IPY L Sbjct: 140 IAMKNGYHGDTIGAVSVGSIELFHHVYGPLM--FESYKAPIPYVYRSESGDPDECRDQCL 197 Query: 213 PALERALQDPN--VAAFMVEP-IQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGL 269 L + L++ + +AA +E +QG +G++V GYL GVRELCT + VL I DE+ TG Sbjct: 198 RELAQLLEEHHEEIAALSIESMVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGF 257 Query: 270 ARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIML-------TIKPGEHGST 322 RTG+ A ++ENV+PD++ GK ++GG P++ +DI +K HG + Sbjct: 258 GRTGKMFACEHENVQPDLMAAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHS 317 Query: 323 YGGNPLGCRVAIAALEVLEEENL----AENADKLGIILRNELMKLPSDVVTAVRGKGLL- 377 Y GN LGC VA+ L + E EN+ AE + KL +L++ L LP V +R G + Sbjct: 318 YTGNQLGCAVALENLALFESENIVEQVAEKSKKLHFLLQD-LHALPH--VGDIRQLGFMC 374 Query: 378 --NAIVIKETKD------WDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESI 429 + KETK+ +KV L++R+ G+L +P GD+I F PPL +EL E + Sbjct: 375 GAELVRSKETKEPYPADRRIGYKVSLKMRELGMLTRPL-GDVIAFLPPLASTAEELSEMV 433 Query: 430 EIINKTI 436 I+ + I Sbjct: 434 AIMKQAI 440 >3R4T-A nrPDB Length = 467 Score = 177 bits (450), Expect = 6e-45, Method: Compositional matrix adjust. Identities = 125/420 (29%), Positives = 208/420 (49%), Gaps = 55/420 (13%) Query: 58 LPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYN 117 LPV + R G + D +G + D S + G+ P++V+A++ QV++ T T Sbjct: 60 LPVFVVRAGGGIVEDADGNRLIDLGSGIAVTTIGNSAPRVVDAVRDQVEQFTHTC----- 114 Query: 118 NVLGEYEEYITKLFNYHKVLP---------MNTGVEAGETACKLARKWGYTVKGIQKYKA 168 ++ YE+Y+ +++ P N+G EA E + K+AR K Sbjct: 115 FMVTPYEQYVAVAEQLNRITPGSGEKRTVLFNSGAEAVENSIKVARA--------HTRKQ 166 Query: 169 KIVFAAGNFWGRTLSAISSSTDPTSY-DGFGPFMPGF----------------DIIPYND 211 +V + GRT ++ + Y GFGPF P DI + Sbjct: 167 AVVAFDYAYHGRTNLTMALTAKSMPYKSGFGPFAPEIYRAPVSYPYRDNLLDKDIATDGE 226 Query: 212 LPA------LERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEI 265 L A +++ + N+AA ++EPI GE G +VP G+L ++ C + V+FIADE+ Sbjct: 227 LAAERAINLIDKQIGAANLAAVIIEPIAGEGGFIVPADGFLPALQRWCRDNDVVFIADEV 286 Query: 266 QTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGG 325 QTG ARTG A D+ENV PD+++ K ++ G +P+SAV +IM G T+GG Sbjct: 287 QTGFARTGAMFACDHENVEPDLIVTAKGIADG-FPLSAVTGRAEIMDAPHTSGLGGTFGG 345 Query: 326 NPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPS--DVVTAVRGKGLLNA--IV 381 NP+ C A+A +E +E + + E A ++ ++ + L++L + D + VRG+G + A +V Sbjct: 346 NPVACAAALATIETIERDGMVERARQIERLVMDRLLRLQAADDRLGDVRGRGAMIAMELV 405 Query: 382 IKETKDWDA---WKVCLRLRDNG--LLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTI 436 T + DA K+ G +L G++IR PPL I ++ L E ++I+ + + Sbjct: 406 KSGTAEPDAALTQKLAAAAHAAGVIVLTCGMFGNVIRLLPPLTISDELLSEGLDILCQIL 465 >6IO1-A nrPDB Length = 451 Score = 173 bits (439), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 133/427 (31%), Positives = 205/427 (48%), Gaps = 51/427 (11%) Query: 52 AHNYHPL----------PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNAL 101 AH+ HPL P+ L RG+G+++WD EG++Y D + VN GH ++ A Sbjct: 17 AHHLHPLTNLYQLRREGPLVLVRGEGVWVWDAEGKRYLDGFAGLWNVNIGHGRRELAEAA 76 Query: 102 KSQVDKLTLTSRAF--YNNVLGEYEEYITKLFN--YHKVLPMNTGVEAGETACKLARKWG 157 + Q++++ F + E + +LF + G E+ ETA K+AR + Sbjct: 77 REQMERVAFVPTFFGLASPPTIELAARLAELFPGPLDHFQFTSGGAESNETAIKIARYY- 135 Query: 158 YTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDII--PY------ 209 + +KG Q + KI+ + G + A+S++ P ++GFGP PGF + PY Sbjct: 136 WWLKG-QPERVKILSRRMAYHGIAMGALSATGVPAYWEGFGPRPPGFIHLTAPYKYRFGE 194 Query: 210 --NDLPALERALQD----------PNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQ 257 D + R +Q+ +AAF+ EP+QG GVVVP GY + + ++ Sbjct: 195 GLTDEEFVARLVQELEETIEREGSETIAAFIGEPVQGAGGVVVPPDGYWPAIAAVLRKYG 254 Query: 258 VLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPG 317 +L I DE+ TG RTG + V+PDIV K ++ G P+ V D+I T+ Sbjct: 255 ILLILDEVITGFGRTGTLFGMQQYGVQPDIVTFAKGITSGYVPLGGVGVSDEIAETLASA 314 Query: 318 E----HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSD-VVTAVR 372 + HG TY G+P+ C VA+ L++L E L ENA G L EL +L V VR Sbjct: 315 DRVFMHGFTYSGHPVACAVALRNLDILLAERLWENAAASGAYLLQELKRLEERPYVGEVR 374 Query: 373 GKGLLNAI-VIKETKDWDAWKVCLRL--------RDNGLLAKPTHGDIIRFAPPLVIKED 423 GKGL+ + V+++ + + +L R G++ + T D I APPL I Sbjct: 375 GKGLMLLVEVVRDKASKEKFPPEFKLGPKLEAATRRRGIIVRCTP-DGIVMAPPLTISRA 433 Query: 424 ELRESIE 430 E IE Sbjct: 434 ECDVLIE 440 >6FYQ-A nrPDB Length = 484 Score = 173 bits (438), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 119/411 (28%), Positives = 205/411 (49%), Gaps = 35/411 (8%) Query: 60 VALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTS--RAFYN 117 V ++ G GIYL DV G+ Y D +SS VN GH ++ A Q+ K+ +S F + Sbjct: 65 VIMKEGDGIYLTDVTGKTYIDGVSSLWNVNVGHGRVELAEAAAQQMKKMAFSSAFSTFSH 124 Query: 118 NVLGEYEEYITKLF--NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAG 175 E I + + V + G E+ ++A KL R + + ++G + K KI+ Sbjct: 125 EPAIRLAEKIASITPEGLNAVFFTSGGSESNDSAVKLVRHY-WKIQG-KPNKRKIISLKR 182 Query: 176 NFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQD----------PNVA 225 ++ G ++ S + P + G M F + + E+A+Q +A Sbjct: 183 SYHGVAAASTSVTGIPEFWGMAGHMMTDFLHVDTHYNNTTEQAVQSLCQAIEEAGPETIA 242 Query: 226 AFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRP 285 AF EP+QG GV++P Y + +RE+C + +LF+ADE+ TG RTG+ ++ +V P Sbjct: 243 AFFAEPVQGAGGVIIPPEDYFLRIREVCNAYGILFVADEVITGFGRTGKMFGIENWDVIP 302 Query: 286 DIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE-----HGSTYGGNPLGCRVAIAALEVL 340 D++ K ++ G +P+ V+ D I +K HG TY G+P VA+ + ++ Sbjct: 303 DVMTFAKGVTSGYFPLGGVVVSDPIHEVLKEKSVGTLFHGFTYSGHPTAAAVALKNIAII 362 Query: 341 EEENLAENADKLGIILRNELMKLPS--DVVTAVRGKGLLNAIVIKETKDWD--------- 389 +EE L EN+ ++G L + L K+ + ++V VR GLL A+ + + + Sbjct: 363 KEERLVENSKRMGDALLHGLKKVKNRLEIVGDVRFVGLLGAVELMQNPATNKPFSSNLQV 422 Query: 390 AWKVCLRLRDNGLLAKPT---HGDIIRFAPPLVIKEDELRESIEIINKTIL 437 A KV L + G++ + H +II APPL+I + ++ + +E+I + IL Sbjct: 423 APKVIEALHELGVICRSVTYDHTNIICLAPPLIINQKQVDKLVEVIYEAIL 473 >3Q8N-A nrPDB Length = 453 Score = 170 bits (430), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 134/411 (32%), Positives = 209/411 (50%), Gaps = 51/411 (12%) Query: 58 LPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYN 117 LPV + G L D +G + DF S + G+ P +V+A+ QV T T Sbjct: 50 LPVYVVAAGGGVLADADGNQLIDFGSGIAVTTVGNSAPAVVDAVTQQVAAFTHTCF---- 105 Query: 118 NVLGEYEEYITKLFNYHKVLP---------MNTGVEAGETACKLARKWGYTVKGIQKYKA 168 ++ YE Y+ + +++ P N+G EA E A K+AR + + +A Sbjct: 106 -MVTPYEGYVKVAEHLNRLTPGDHEKRTALFNSGAEAVENAVKIARAY-------TRRQA 157 Query: 169 KIVFAAGNFWGRT--LSAISSSTDPTSYDGFGPFMPGFDIIP----YND----------- 211 +VF + GRT A+++ P + GFGPF +P + D Sbjct: 158 VVVFDHA-YHGRTNLTMAMTAKNQPYKH-GFGPFANEVYRVPTSYPFRDGETDGAAAAAH 215 Query: 212 -LPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLA 270 L + + + NVAA ++EP+ GE G VVP PG+L +++ CT + +F+ADE+QTG A Sbjct: 216 ALDLINKQVGADNVAAVVIEPVHGEGGFVVPAPGFLGALQKWCTDNGAVFVADEVQTGFA 275 Query: 271 RTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGC 330 RTG A ++ENV PD+++ K ++GGL P+SAV +IM + G G TYGGNPL C Sbjct: 276 RTGALFACEHENVVPDLIVTAKGIAGGL-PLSAVTGRAEIMDGPQSGGLGGTYGGNPLAC 334 Query: 331 RVAIAALEVLEEENLAENADKLGIILRNELMKLPSD--VVTAVRGKGLLNAI--VIKETK 386 A+A ++ +E ENL A +G + + L L + + VRG+G + A+ V T Sbjct: 335 AAALAVIDTIERENLVARARAIGETMLSRLGALAAADPRIGEVRGRGAMIAVELVKPGTT 394 Query: 387 DWDA---WKVCLRLRDNGL--LAKPTHGDIIRFAPPLVIKEDELRESIEII 432 + DA +V GL L T+G+++RF PPL + + L E ++I+ Sbjct: 395 EPDADLTKRVAAAAHAQGLVVLTCGTYGNVLRFLPPLSMPDHLLDEGLDIL 445 >5LL2-A nrPDB Length = 480 Score = 167 bits (422), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 127/430 (29%), Positives = 212/430 (49%), Gaps = 50/430 (11%) Query: 43 IFEREYKYGAH----NYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIV 98 + + E KY A NY+ L ++ G L DV+G KY D L+S SA+N GH H K+V Sbjct: 40 LIDEENKYYARSARINYYNL--VIDHAHGATLVDVDGNKYIDLLASASAINVGHTHEKVV 97 Query: 99 NALKSQVDKLTLTSRAFYNNVLG-EYEEYITKLF--NYHKVLPM-NTGVEAGETACKLAR 154 A+ Q KL + A++++V G E E + K+ N K++ N+G +A + K AR Sbjct: 98 KAIADQAQKLIHYTPAYFHHVPGMELSEKLAKIAPGNSPKMVSFGNSGSDANDAIIKFAR 157 Query: 155 KWGYTVKGIQKYKAKIVFAAGNFWGRTL-SAISSSTDPTSYDGFGPFMPGFDIIPYND-- 211 + + IV G++ G T S S + GP +P +PY D Sbjct: 158 AY--------TGRQYIVSYMGSYHGSTYGSQTLSGSSLNMTRKIGPMLPSVVHVPYPDSY 209 Query: 212 --LPA-----------------LERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVREL 252 P E L A ++EPIQG+ G++ Y+ V + Sbjct: 210 RTYPGETEHDVSLRYFNEFKKPFESFLPADETACVLIEPIQGDGGIIKAPEEYMQLVYKF 269 Query: 253 CTRHQVLFIADEIQTGLARTGR-WLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIM 311 C H +LF DE+ GL RTG+ W ++++ PD++ +GK+L+ G+ P+SAV+ ++M Sbjct: 270 CHEHGILFAIDEVNQGLGRTGKMWAIQQFKDIEPDLMSVGKSLASGM-PLSAVIGKKEVM 328 Query: 312 LTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSD--VVT 369 ++ H T GNP+ ++A L+V+E E L E + G + +++ ++ Sbjct: 329 QSLDAPAHLFTTAGNPVCSAASLATLDVIEYEGLVEKSATDGAYAKQRFLEMQQRHPMIG 388 Query: 370 AVRGKGLLNAI-VIKE--TKDWD---AWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKED 423 VR GL I ++K+ TK+ D A KV +G++ G+I+RF PPLVI + Sbjct: 389 DVRMWGLNGGIELVKDPKTKEPDSDAATKVIYYAFAHGVVIITLAGNILRFQPPLVIPRE 448 Query: 424 ELRESIEIIN 433 +L +++++++ Sbjct: 449 QLDQALQVLD 458 >5LH9-A nrPDB Length = 458 Score = 155 bits (393), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 123/417 (29%), Positives = 193/417 (46%), Gaps = 63/417 (15%) Query: 60 VALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNV 119 + + RG G Y+ D++G++ D + VN GH + A+ +Q+D+L A+Y Sbjct: 37 LVIARGDGNYITDIDGQRMLDGVGGLWNVNIGHNRASVKAAIAAQLDEL-----AYYQTF 91 Query: 120 LG-------EYEEYITKLF---NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAK 169 G + E +T +F +VL + G +A ETA K+AR+ Y + + + + Sbjct: 92 DGIAHPRVFDLAERLTGMFAQERMARVLFSSGGSDAVETALKMARQ--YWIASGEPGRTR 149 Query: 170 IVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERA---LQDPN--- 223 + + G + S + + G + G ++ D P L R +DP Sbjct: 150 FLSLRNGYHGVHMGGTSVGGNGVYHYNHGQLLAGCHLL---DTPWLYRNPWDCRDPQALT 206 Query: 224 ------------------VAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEI 265 +AA + EP+QG GV+VP Y +RE+C RH +L IADE+ Sbjct: 207 AHCIRQLEEQIALLGAQTIAALIAEPVQGAGGVIVPPADYWPRLREVCDRHGILLIADEV 266 Query: 266 QTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE------- 318 TG R+G L V PDI+ L K ++ G P+ A L + I I+ G+ Sbjct: 267 VTGFGRSGCMLGSRGWGVAPDILCLAKGITAGYIPLGATLFNQRIADAIENGQGFSHMIM 326 Query: 319 HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSD--VVTAVRGKGL 376 HG TY G+P C A+A L+++E E+L NA K+G L +L L VV VRGKGL Sbjct: 327 HGYTYSGHPTACAAALAVLDIVEAEDLPGNAAKVGAQLLEQLQPLVERYAVVGEVRGKGL 386 Query: 377 LNAIVI---KETKD------WDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDE 424 + A+ + K T+ ++ R G+L +P G+ I +PPL + DE Sbjct: 387 MIALDLVSDKRTRQPLDPAAGQPSRIADEARRAGVLVRPI-GNKIILSPPLTLTRDE 442 >5KR6-A nrPDB Length = 479 Score = 154 bits (390), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 131/456 (28%), Positives = 207/456 (45%), Gaps = 67/456 (14%) Query: 40 SDDIFEREYKYGAHNYHP-----------LP-VALERGKGIYLWDVEGRKYFDFLSSYSA 87 +DD+ E + AH +HP LP + GKGI + D EGR+Y D + Sbjct: 24 TDDLLEMDR---AHFFHPSTHLRDHASGELPGRIITGGKGIRIQDSEGREYIDAFAGLYC 80 Query: 88 VNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKL----------FNYHKVL 137 VN G+ +I +A+ Q +L A+Y+ +G E I +L KV Sbjct: 81 VNVGYGRTEIADAIYEQAKEL-----AYYHTYVGHSNEPIIELSERIIREWAPAGMSKVY 135 Query: 138 PMNTGVEAGETACKL-----------------ARKWGYTVKGIQKYKAKIVFAAGNFWGR 180 +G +A ET KL +R+ GY GI + A N + Sbjct: 136 YGMSGSDANETQIKLVWYYNNVLGRPQKKKIISRQRGYHGSGIMTGSLTGLPAFHNHFDL 195 Query: 181 TLSAISSSTDPTSYDG-FGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVV 239 L I +T P Y G F ++L + A VAAF+ EP+ G G+V Sbjct: 196 PLEPIRHTTCPHYYRAPAGMSEAEFSRHCADELEKMILAEGPDTVAAFIGEPVMGTGGIV 255 Query: 240 VPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLY 299 P GY ++ + ++ +L IADE+ G RTG + ++PD++ + K L+ Sbjct: 256 PPPEGYWEAIQAVLNKYDILLIADEVVCGFGRTGSMFGSHHYGMKPDLITVAKGLTSAYA 315 Query: 300 PVSAVLCDDDIMLTIKPGE-------HGSTYGGNPLGCRVAIAALEVLEEENLAENADKL 352 P+S V+ + + ++ G HG TY G+P+ A+A L+++E ENL NA Sbjct: 316 PLSGVIVGEKVWKVLEQGSDQYGPIGHGWTYSGHPICAAAALANLDIIERENLTGNAADT 375 Query: 353 GIILRNELMKLPSD--VVTAVRGKGLLNAIVIKETKD----WD-AWKVCLRLR----DNG 401 G + + + D +V VRG GL+ A+ KD +D + KV R+ ++G Sbjct: 376 GAYFQQRMRETFGDHPLVGEVRGVGLMAALEFVADKDKRTRFDPSLKVGPRVSAACLEDG 435 Query: 402 LLAKPT-HGDIIRFAPPLVIKEDELRESIEIINKTI 436 ++A+ HGDI+ FAPPLVI E+ E ++I + + Sbjct: 436 MIARAMPHGDILGFAPPLVITRAEVDEIVDIAKQAV 471 >4FFC-A nrPDB Length = 453 Score = 153 bits (386), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 139/449 (30%), Positives = 210/449 (46%), Gaps = 54/449 (12%) Query: 28 VATKKTVQGP---PTSDDIFERE-YKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLS 83 +A K+T+ P P S + ER A PV G + D +G + D + Sbjct: 12 LAQKRTIVTPLPGPRSGALAERRRAAVSAGVGSTAPVYAVDADGGVIVDADGNSFIDLGA 71 Query: 84 SYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYI--TKLFNY-------H 134 + G HP + A+ Q T T ++ YE+Y+ +L N Sbjct: 72 GIAVTTVGASHPAVAAAIADQATHFTHTC-----FMVTPYEQYVQVAELLNALTPGDHDK 126 Query: 135 KVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSY 194 + N+G EA E A K+AR + + +V + GRT ++ + Y Sbjct: 127 RTALFNSGAEAVENAIKVAR--------LATGRPAVVAFDNAYHGRTNLTMALTAKSMPY 178 Query: 195 DG-FGPFMPGFDIIPYN----DLPAL-------------ERALQDPNVAAFMVEPIQGEA 236 FGPF P +P + D P L E + ++AA ++EPIQGE Sbjct: 179 KSQFGPFAPEVYRMPASYPLRDEPGLTGEEAARRAISRIETQIGAQSLAAIIIEPIQGEG 238 Query: 237 GVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSG 296 G +VP PG+L + + + V+FIADE+QTG ARTG W A ++E + PDIV + K ++G Sbjct: 239 GFIVPAPGFLATLTAWASENGVVFIADEVQTGFARTGAWFASEHEGIVPDIVTMAKGIAG 298 Query: 297 GLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIIL 356 G+ P+SAV ++M + G G TYGGNP+ C A+AAL V+ E +L A + + Sbjct: 299 GM-PLSAVTGRAELMDAVYAGGLGGTYGGNPVTCAAAVAALGVMRELDLPARARAIEASV 357 Query: 357 RNELMKLPS--DVVTAVRGKGLLNAIVIKE--TKDWDAW---KVCLRLRDNG--LLAKPT 407 + L L D++ VRG+G + AI I + T + DA + G +L T Sbjct: 358 TSRLSALAEEVDIIGEVRGRGAMLAIEIVKPGTLEPDAALTKSIAAEALSQGVLILTCGT 417 Query: 408 HGDIIRFAPPLVIKEDELRESIEIINKTI 436 G++IR PPLVI +D L E I ++ I Sbjct: 418 FGNVIRLLPPLVIGDDLLDEGITALSDII 446 >3N5M-A nrPDB Length = 452 Score = 153 bits (386), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 118/432 (27%), Positives = 208/432 (48%), Gaps = 48/432 (11%) Query: 40 SDDIFEREYKYGAHNYHPLP----VALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHP 95 +D++ ++ +Y H P + +G ++ D++G++Y D +S VN G+ Sbjct: 9 TDELLAKDEQYVWHGMRPFSPNSTTVGAKAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRK 68 Query: 96 KIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITK-LFNYHKVLPMNTGVEAGETACKLAR 154 ++ A Q+ L+ + + + E + + L + + N+G EA ETA K+AR Sbjct: 69 ELAEAAYKQLQTLSYFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIAR 128 Query: 155 KWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYND--- 211 ++ Y KG + ++ K + + G T++ ++++ + PF GF + D Sbjct: 129 QY-YAQKG-EPHRYKFMSRYRGYHGNTMATMAATGQAQRRYQYEPFASGFLHVTPPDCYR 186 Query: 212 LPALERA-LQD----------------PNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCT 254 +P +ER + D +AAF++EPI G+++ Y+ V E C Sbjct: 187 MPGIERENIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMAPQDYMKAVHETCQ 246 Query: 255 RHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTI 314 +H L I+DE+ G RTG+ +V+PDI+ + K ++ P+SA +I Sbjct: 247 KHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKREIYEAF 306 Query: 315 K-PGE-----HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSD-- 366 K GE H +T+GGNP C +A+ LE++E ENL E + ++G +L +L + + Sbjct: 307 KGKGEYEFFRHINTFGGNPAACALALKNLEIIENENLIERSAQMGSLLLEQLKEEIGEHP 366 Query: 367 VVTAVRGKGLLNAIVI---KETK---DWDA-WKVCLRLRDNGL------LAKPTHGDIIR 413 +V +RGKGLL I + KETK D D V ++ GL + + +I+ Sbjct: 367 LVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVNACKEKGLIIGRNGMTTAGYNNILT 426 Query: 414 FAPPLVIKEDEL 425 APPLVI +E+ Sbjct: 427 LAPPLVISSEEI 438 >5UC7-A nrPDB Length = 431 Score = 151 bits (382), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 132/439 (30%), Positives = 205/439 (46%), Gaps = 53/439 (12%) Query: 35 QGPPTSDDIFEREYKYGAHNY----HPLPV-ALERGKGIYLWDVEGRKYFDFLSSYSAVN 89 QG T D F+R + + H Y PLPV +ER +G L G + D +SS+ A Sbjct: 1 QGMTTDDLAFDRRHIW--HPYTSMTSPLPVFPVERAEGCELILSGGERLVDGMSSWWAAI 58 Query: 90 QGHCHPKIVNALKSQVDKLTLTSRAFYNNVL-GEYEEYITKLFNY-----HKVLPMNTGV 143 G+ HP++ A+K+Q+D + S + + E KL V ++G Sbjct: 59 HGYNHPQLNAAMKTQIDAM---SHVMFGGITHAPAIELCRKLVAMTPAPLECVFLADSGS 115 Query: 144 EAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTS--------YD 195 A E A K+A ++ + KG + + + + + G T A+S DP + Y Sbjct: 116 VAVEVAMKMALQY-WQAKG--ESRQRFLTFRNGYHGDTFGAMSVC-DPHNSMHSLWKGYL 171 Query: 196 GFGPFMPG-----------FDIIPYNDLPALERALQDPNVAAFMVEPI-QGEAGVVVPDP 243 F P D++ + L A R +AA ++EPI QG G+ + P Sbjct: 172 AENLFAPAPQSRMGGEWDERDMVAFARLMAAHRH----EIAAVILEPIVQGAGGMRIYHP 227 Query: 244 GYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSA 303 +L +R++C R +L IADEI TG RTGR A ++ + PDI+ LGKAL+GG +SA Sbjct: 228 QWLQRIRQMCDREGILLIADEIATGFGRTGRLFACEHAGIAPDILCLGKALTGGTMTLSA 287 Query: 304 VLCDDDIMLTIKPGE-----HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRN 358 L + TI GE HG T+ GNPL C VA A+L +LE + + LR Sbjct: 288 TLTSRQVAETISNGEAGCFMHGPTFMGNPLACAVANASLTLLESGDWRRQVAAIEAQLRE 347 Query: 359 ELMKLPSDVVTAVRGKGLLNAI-VIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPP 417 EL P+ V +L AI V++ T+ + + G+ +P G +I PP Sbjct: 348 ELA--PAADSPQVADVRVLGAIGVVETTRPVNIAALQQFFVRQGVWVRP-FGKLIYLMPP 404 Query: 418 LVIKEDELRESIEIINKTI 436 +I+ ++LR + +N+ + Sbjct: 405 YIIQPEQLRRLTQAVNEAV 423 >1ZOD-A nrPDB Length = 433 Score = 151 bits (381), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 128/420 (30%), Positives = 195/420 (46%), Gaps = 58/420 (13%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLT-LTSRAFYN 117 P+ +ER KG +++D +GR DF S + GHCHP+IV+ + KL L S Sbjct: 26 PMIIERAKGSFVYDADGRAILDFTSGQMSAVLGHCHPEIVSVIGEYAGKLDHLFSEMLSR 85 Query: 118 NVLGEYEEYITKLFN-----YHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVF 172 V+ + T+L N + L ++TG E+ E A ++A+ V G K +IV Sbjct: 86 PVV----DLATRLANITPPGLDRALLLSTGAESNEAAIRMAK----LVTG----KYEIVG 133 Query: 173 AAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIP--------------YNDLPALERA 218 A ++ G T A +S+T G GP G IP Y+ L L+ A Sbjct: 134 FAQSWHGMT-GAAASATYSAGRKGVGPAAVGSFAIPAPFTYRPRFERNGAYDYLAELDYA 192 Query: 219 L------QDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLART 272 N+AAF+ EPI G++ GY+ ++ C +L I DE QTG+ RT Sbjct: 193 FDLIDRQSSGNLAAFIAEPILSSGGIIELPDGYMAALKRKCEARGMLLILDEAQTGVGRT 252 Query: 273 GRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHG----STYGGNPL 328 G A + V PDI+ L K L GL P++A++ I + E G +T+ +PL Sbjct: 253 GTMFACQRDGVTPDILTLSKTLGAGL-PLAAIVTSAAI--EERAHELGYLFYTTHVSDPL 309 Query: 329 GCRVAIAALEVLEEENLAENADKLGIILRNELMKLPS--DVVTAVRGKGLLNAIVI---- 382 V + L+V++ + L A+ +G LR L+ L D + VRG+GLL + I Sbjct: 310 PAAVGLRVLDVVQRDGLVARANVMGDRLRRGLLDLMERFDCIGDVRGRGLLLGVEIVKDR 369 Query: 383 --KETKDWDAWKVCLRLRDNGL----LAKPTHGDIIRFAPPLVIKEDELRESIEIINKTI 436 KE D K+ + GL + P G + R APPL + EDE+ + ++ + I Sbjct: 370 RTKEPADGLGAKITRECMNLGLSMNIVQLPGMGGVFRIAPPLTVSEDEIDLGLSLLGQAI 429 >4UHN-A nrPDB Length = 468 Score = 150 bits (379), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 117/421 (27%), Positives = 192/421 (45%), Gaps = 43/421 (10%) Query: 54 NYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSR 113 N+H P + +G +L D +GR+ +D LS GH +I +A+ Q+ L + Sbjct: 49 NFHKDPRIIVAAEGSWLVDDKGRRIYDSLSGLWTCGAGHSRKEIADAVAKQIGTLDYSPG 108 Query: 114 AFYNNVLG-EYEEYITKLF--NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKI 170 Y + L + E I ++ V +G E +T+ K+AR + + +KG Q K K+ Sbjct: 109 FQYGHPLSFQLAEKIAQMTPGTLDHVFFTGSGSECADTSIKMARAY-WRIKG-QAQKTKL 166 Query: 171 VFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPY--------------------- 209 + A + G ++ S + FGP M D +P+ Sbjct: 167 IGRARGYHGVNVAGTSLGGIGGNRKMFGPLMD-VDHLPHTLQPGMAFTKGAAETGGVELA 225 Query: 210 NDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGL 269 N+L L N+AA +VEP+ G AGV+VP GYL +RE+C + +L I DE+ T Sbjct: 226 NELLKLIELHDASNIAAVIVEPMSGSAGVIVPPKGYLQRLREICDANDILLIFDEVITAF 285 Query: 270 ARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE---------HG 320 R G+ +Y V PDI+ + K ++ G P+ AV+ +I T HG Sbjct: 286 GRMGKATGAEYFGVTPDIMNVAKQVTNGAVPMGAVIASSEIYDTFMNQNLPEYAVEFGHG 345 Query: 321 STYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLP-SDVVTAVRGKGLLNA 379 TY +P+ C IAAL++L++ENL + + +L L L + V +R GL A Sbjct: 346 YTYSAHPVACAAGIAALDLLQKENLIQQSAELAPHFEKALHGLKGTKNVIDIRNCGLAGA 405 Query: 380 IVIKETKDWDA----WKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKT 435 I I +D DA ++ ++L G + GD ++F P K ++L + + + Sbjct: 406 IQIA-ARDGDAIVRPFEASMKLWKEGFYVR-FGGDTLQFGPTFNAKPEDLDRLFDAVGEA 463 Query: 436 I 436 + Sbjct: 464 L 464 >6ERK-A nrPDB Length = 451 Score = 148 bits (373), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 127/442 (28%), Positives = 211/442 (47%), Gaps = 50/442 (11%) Query: 35 QGPPTSDDIFEREYKYGAHNYHPLP-----VALERGKGIYLWDVEGRKYFDFLSSYSAVN 89 QG T+ + + ++ H Y LP + ++R +GIY+ +G + D +SS+ A Sbjct: 18 QGHMTTVSTNDFDQQHLWHPYASLPPTYPNIVIDRAEGIYIVTEDGTRLIDGMSSWWASV 77 Query: 90 QGHCHPKIVNALKSQVDKLT------LTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGV 143 G+ HPK+ A+ Q+ K+ LT + + LG+ I + ++G Sbjct: 78 HGYNHPKLNAAMIEQLGKMAHVMFGGLTHQPAID--LGKKLLSIVPA-GLDAIFYADSGS 134 Query: 144 EAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTS--YDGFGPFM 201 A E A K+A + Y + + K + ++G T A+S DP + + +G + Sbjct: 135 IAVEVALKMALQ--YQIAAKRPSKCQFASTHSGYYGDTWHAMSVC-DPINGMHSLYGKQL 191 Query: 202 P----------GFDIIPYNDLPALER-ALQD------PNVAAFMVEPI-QGEAGVVVPDP 243 P GF+ DL ER AL + +A F++EPI QG G+ P Sbjct: 192 PMQHFVAAPPMGFE----RDLTQSEREALTEFFVKNSDKLAGFIIEPIIQGAGGMRFYSP 247 Query: 244 GYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSA 303 YL +R+LC + VL IADEI TG R+G+ A ++ + PDI+ +GKAL+GG +A Sbjct: 248 QYLQLLRKLCDEYDVLLIADEIATGFGRSGKLFACEHAAISPDIMTIGKALTGGYMTFAA 307 Query: 304 VLCDDDIMLTIKPGE-----HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRN 358 L +I TI + HG T+ GNPL C VA A+++++ ++ + + I+ Sbjct: 308 TLSTREIADTISQSDYPALMHGPTFMGNPLACAVACASIDLIVSYDIEARTENMQAIMNE 367 Query: 359 ELMKLPS-DVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPP 417 +L S + V VR G + I + E D ++ L +NG+ +P G ++ PP Sbjct: 368 QLAPAVSLEGVKEVRCLGAVAVIELNEAVDMPIFQTL--LINNGIWVRP-FGKLVYIMPP 424 Query: 418 LVIKEDELRESIEIINKTILSF 439 VI +DEL + + K + S+ Sbjct: 425 YVITDDELTTLCQALLKVVSSY 446 >3L44-A nrPDB Length = 434 Score = 147 bits (372), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 118/350 (33%), Positives = 170/350 (48%), Gaps = 31/350 (8%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTL--TSRAFY 116 P+A+ERGKG Y WDV+G KY D+L++Y + GH HP I A+ + + L T A Sbjct: 38 PIAMERGKGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITKAITTAAENGVLYGTPTALE 97 Query: 117 NNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGN 176 +E + L KV +N+G EA T ++AR + + KI+ AG Sbjct: 98 VKFAKMLKEAMPAL---DKVRFVNSGTEAVMTTIRVARAY--------TGRTKIMKFAGC 146 Query: 177 FWGRT-LSAISSSTDPTSY---DGFG-PFMPGFDII--PYNDLPALERALQD--PNVAAF 227 + G + L +++ + P++ D G P ++I P+N++ L+ AL VAA Sbjct: 147 YHGHSDLVLVAAGSGPSTLGTPDSAGVPQSIAQEVITVPFNNVETLKEALDKWGHEVAAI 206 Query: 228 MVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDI 287 +VEPI G G+V P PG+L V EL L I DE+ T R A D V PD+ Sbjct: 207 LVEPIVGNFGIVEPKPGFLEKVNELVHEAGALVIYDEVITAF-RFMYGGAQDLLGVTPDL 265 Query: 288 VLLGKALSGGLYPVSAVLCDDDIMLTIK---PGEHGSTYGGNPLGCRVAIAALEVLEEEN 344 LGK + GGL P+ A +IM + P T GNP IA LEVL++E Sbjct: 266 TALGKVIGGGL-PIGAYGGKKEIMEQVAPLGPAYQAGTMAGNPASMASGIACLEVLQQEG 324 Query: 345 LAENADKLGIILRNELMKLPSDV---VTAVRGKGLLNAIVIKET-KDWDA 390 L E D+LG L +++ + +T R KG L T +D+DA Sbjct: 325 LYEKLDELGATLEKGILEQAAKHNIDITLNRLKGALTVYFTTNTIEDYDA 374 >5KQW-A nrPDB Length = 479 Score = 146 bits (369), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 128/457 (28%), Positives = 203/457 (44%), Gaps = 71/457 (15%) Query: 41 DDIFEREYKYGAHNYHPLPVALER------------GKGIYLWDVEGRKYFDFLSSYSAV 88 D +FE + AH HP A + GKGI + D EGR+Y D + V Sbjct: 25 DQLFEMDR---AHFMHPSTHAHDHASGALPGRIITGGKGIRIQDHEGREYIDAFAGLYCV 81 Query: 89 NQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFN----------YHKVLP 138 N G+ ++ +A+ Q +L A+Y+ +G E I +L + KV Sbjct: 82 NIGYGRTEVADAIYEQAKEL-----AYYHTYVGHSTEAIIELSSRIIRDWAPAGMKKVYY 136 Query: 139 MNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFG 198 +G +A ET KL W Y + K KI+ + G + S + P+ + F Sbjct: 137 GMSGSDANETQIKLV--WYYNNVLGRPQKKKIISRQRGYHGSGIMTGSLTGLPSFHQHFD 194 Query: 199 -PF-----------------MPGFDIIPY--NDLPALERALQDPNVAAFMVEPIQGEAGV 238 P M + Y ++L L A VAAF+ EP+ G G+ Sbjct: 195 LPIERIKHTVCPHWYKAPAGMSEAQFVRYCADELEKLILAEGPDTVAAFIGEPVMGTGGI 254 Query: 239 VVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGL 298 + P GY ++ + ++ +L IADE+ G R G + + ++PD++ + K L+ Sbjct: 255 IPPPQGYWEAIQAVLNKYDILLIADEVVCGFGRLGSKMGSQHYGMKPDLITVAKGLTSAY 314 Query: 299 YPVSAVLCDDDIMLTIKPGE-------HGSTYGGNPLGCRVAIAALEVLEEENLAENADK 351 P+S V+ + + I+ G HG TY G+P+ A+A L++LE ENL NA Sbjct: 315 APLSGVIVGEKVWDVIEKGSQEHGPMGHGWTYSGHPICAAAALANLDILERENLTGNAAD 374 Query: 352 LGIILRNELMKL--PSDVVTAVRGKGLLNAIVIKETKD----WD-----AWKVCLRLRDN 400 +G L+ L + +V VRG G+L A+ KD +D KV ++ Sbjct: 375 VGAYLQQRLRETFGGHPLVGEVRGVGMLAALEFMADKDARTPFDPALKVGPKVSAACLED 434 Query: 401 GLLAKPT-HGDIIRFAPPLVIKEDELRESIEIINKTI 436 G++A+ HGDI+ FAPPLVI E+ E + I + + Sbjct: 435 GMIARAMPHGDILGFAPPLVITRAEVDEIVGIAKQAV 471 >6G4F-A nrPDB Length = 464 Score = 146 bits (368), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 116/442 (26%), Positives = 206/442 (46%), Gaps = 54/442 (12%) Query: 45 EREYKYGAHNYHPL-------PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKI 97 E++ +Y H Y P+ +ERG+GIY++D +G+ Y + ++ + G + ++ Sbjct: 10 EKDIQYQLHPYTNARLHQELGPLIIERGEGIYVYDDQGKGYIEAMAGLWSAALGFSNQRL 69 Query: 98 VNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNY-----HKVLPMNTGVEAGETACKL 152 + A + Q + L F + E KL KV N+G EA +T K+ Sbjct: 70 IKAAEQQFNTLPFY-HLFSHKSHRPSIELAEKLIEMAPVPMSKVFFTNSGSEANDTVVKM 128 Query: 153 ARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDII--PYN 210 W + K K + + G T+++ S + P + GF +PGF + P++ Sbjct: 129 V--WYLNNALGKPAKKKFISRVNGYHGITVASASLTGLPGNQRGFDLPLPGFLHVGCPHH 186 Query: 211 DLPAL----ERALQD---------------PNVAAFMVEPIQGEAGVVVPDPGYLMGVRE 251 AL E D +AAF+ EP+ G GV+VP Y +++ Sbjct: 187 YRFALAGESEEHFADRLAVELEQKILAEGPETIAAFIGEPLMGAGGVIVPPRTYWEKIQK 246 Query: 252 LCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIM 311 +C ++ +L IADE+ G RTG+ ++PDI++L K LS P++A+L + + Sbjct: 247 VCRKYDILVIADEVICGFGRTGQMFGSQTFGIQPDIMVLSKQLSSSYQPIAAILINAPVF 306 Query: 312 LTIKPGE-------HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMK-L 363 I HG T G+P+ VA+ L+++EEE+L E+A ++G +LR+ L + Sbjct: 307 EGIADQSQALGALGHGFTGSGHPVATAVALENLKIIEEESLVEHAAQMGQLLRSGLQHFI 366 Query: 364 PSDVVTAVRGKGLLNAIVIKETKDWDAWKVCL---------RLRDNGLLAKPTHGDIIRF 414 +V +RG GL+ A+ + + A L R +++G++ + GD + F Sbjct: 367 DHPLVGEIRGCGLIAAVELVGDRVSKAPYQALGTLGRYMAGRAQEHGMITRAM-GDAVAF 425 Query: 415 APPLVIKEDELRESIEIINKTI 436 PPL++ E E+ +E + + Sbjct: 426 CPPLIVNEQEVGMIVERFARAL 447 >5KR3-A nrPDB Length = 479 Score = 145 bits (366), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 125/460 (27%), Positives = 201/460 (43%), Gaps = 77/460 (16%) Query: 41 DDIFEREYKYGAHNYHPLPVALER------------GKGIYLWDVEGRKYFDFLSSYSAV 88 D +FE + AH HP A + GKGI + D EGR+Y D + V Sbjct: 25 DQLFEMDR---AHFMHPSTHAHDHASGALPGRIITGGKGIRIEDHEGREYIDAFAGLYCV 81 Query: 89 NQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFN----------YHKVLP 138 N G+ ++ +A+ Q +L A+Y+ +G + I +L + KV Sbjct: 82 NIGYGRTEVADAIYEQAKQL-----AYYHTYVGHSTDAIIELSSRIIRDWAPAGMKKVYY 136 Query: 139 MNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFG 198 +G +A ET KL W Y + K KI+ + G + S + P+ + F Sbjct: 137 GMSGSDANETQIKLV--WYYNNVLGRPNKKKIISRERGYHGSGIVTGSLTGLPSFHQHFD 194 Query: 199 PFMPGFDIIPYNDLPALERALQD-----------------------PNVAAFMVEPIQGE 235 +P D + + P RA +AAF+ EP+ G Sbjct: 195 --LP-IDRVKHTVCPHWYRAPAGMSEAQFVAYCVEELEKLIAREGADTIAAFIAEPVMGT 251 Query: 236 AGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALS 295 G++ P GY ++ + +H +L IADE+ G R G + + ++PD++ + K L+ Sbjct: 252 GGIIPPPQGYWEAIQAVLRKHDILLIADEVVCGFGRLGSKMGSQHYGIKPDLITVAKGLT 311 Query: 296 GGLYPVSAVLCDDDIMLTIKPGE-------HGSTYGGNPLGCRVAIAALEVLEEENLAEN 348 P+S V+ + + I+ G HG TY G+P+ A+A L++LE ENL N Sbjct: 312 SAYAPLSGVIVGEKVWDVIEKGSQEHGPMGHGWTYSGHPICAAAALANLDILERENLTGN 371 Query: 349 ADKLGIILRNELMKL--PSDVVTAVRGKGLLNAIVIKETKD----WD-----AWKVCLRL 397 A +G L+ L + +V VRG G+L A+ KD +D KV Sbjct: 372 AADVGAYLQQRLHEAFGAHPLVGEVRGVGMLAALEFMADKDARTPFDPALKVGPKVSAAA 431 Query: 398 RDNGLLAKPT-HGDIIRFAPPLVIKEDELRESIEIINKTI 436 ++G++A+ HGDI+ FAPPLV E+ E + I + + Sbjct: 432 LEDGMIARAMPHGDILGFAPPLVTTRAEVDEIVGIAKQAV 471 >5KR5-A nrPDB Length = 479 Score = 145 bits (366), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 117/421 (27%), Positives = 189/421 (44%), Gaps = 56/421 (13%) Query: 65 GKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYE 124 GKGI + D EGR+Y D + VN G+ ++ +A+ Q +L A+Y+ +G Sbjct: 58 GKGIRIEDHEGREYIDAFAGLYCVNIGYGREEVADAIYEQAKQL-----AYYHTYVGHSN 112 Query: 125 EYITKLFN----------YHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAA 174 + + +L + KV +G +A ET KL W Y + K KI+ Sbjct: 113 DPVIELSSRIIEDWAPAGMKKVFYGMSGSDANETQIKLV--WYYNNVLGRPNKKKIIARE 170 Query: 175 GNFWGRTLSAISSSTDPTSYDGFG------------------PFMPGFDIIPY--NDLPA 214 ++ G + S + P+ + F P M + Y +L Sbjct: 171 RSYHGSGIVTGSLTGLPSFHQHFDLPIDRVKHTVCPHWYNAPPGMSEAQFVAYCVEELEK 230 Query: 215 LERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGR 274 L +AAF+ EP+ G G+V P GY ++ + +H +L IADE+ G R G Sbjct: 231 LIAREGADTIAAFIAEPVMGTGGIVPPPQGYWEAIQAVLRKHDILLIADEVVCGFGRLGS 290 Query: 275 WLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE-------HGSTYGGNP 327 ++ ++PD++ + K L+ P+SAV+ + + I+ G HG TY G+P Sbjct: 291 KTGSEHYGIKPDLITVAKGLTSAYAPLSAVIVSEKVWDVIEKGSREHGVMGHGWTYSGHP 350 Query: 328 LGCRVAIAALEVLEEENLAENADKLGIILRNELMKL--PSDVVTAVRGKGLLNAIVIKET 385 + A+A L++LE ENL NA +G L+ L + +V VRG G+L A+ Sbjct: 351 VCAAAALANLDILERENLTGNAADVGAYLQQRLHEAFGAHPLVGEVRGVGMLAALEFMAD 410 Query: 386 KD----WD-----AWKVCLRLRDNGLLAKPT-HGDIIRFAPPLVIKEDELRESIEIINKT 435 K +D + KV ++GL+ + HGDI+ FAPPLV E+ E + I + Sbjct: 411 KGARTPFDPALKVSQKVAAAALEDGLIVRALPHGDILGFAPPLVTTRAEVDEIVAIAKEA 470 Query: 436 I 436 Sbjct: 471 F 471 >4ATP-A nrPDB Length = 456 Score = 144 bits (362), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 131/456 (28%), Positives = 217/456 (47%), Gaps = 62/456 (13%) Query: 28 VATKKTVQGP---PTSDDIFEREYKYGAHNYHP-LPVALERGKGIYLWDVEGRKYFDFLS 83 + K+ + G P S + ER A +PV +E G + DV+G + D S Sbjct: 12 IEQKRNINGAFPGPKSQALAERRSAVVAAGVASGVPVYVEDADGGIIRDVDGNSFIDLGS 71 Query: 84 SYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLP----- 138 + + G P +V A++ T T ++ YE Y+ +++ P Sbjct: 72 GIAVTSVGASDPAVVAAVQEAAAHFTHTCF-----MVTPYEGYVAVTEQLNRLTPGDHAK 126 Query: 139 ----MNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSY 194 N+G EA E A K+AR + + +V + GRT ++ + Y Sbjct: 127 RTVLFNSGAEAVENAVKVAR--------LATGRDAVVAFDHAYHGRTNLTMALTAKAMPY 178 Query: 195 D-GFGPFMPGFDIIPYN------------------DLPALERALQDPNVAAFMVEPIQGE 235 FGPF P +P + + +E+ + VAA ++EPIQGE Sbjct: 179 KTNFGPFAPEVYRMPMSYPFREENPEITGAEAAKRAITMIEKQIGGDQVAAIIIEPIQGE 238 Query: 236 AGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALS 295 G +VP G+L + E ++FIADE+Q+G RTG W AVD+E V PDI+ + K ++ Sbjct: 239 GGFIVPAEGFLPALSEWAKEKGIVFIADEVQSGFCRTGEWFAVDHEGVVPDIITMAKGIA 298 Query: 296 GGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGII 355 GGL P+SA+ D++ + PG G TYGGNP+ C A+AA++ +E+ +L A + + Sbjct: 299 GGL-PLSAITGRADLLDAVHPGGLGGTYGGNPVACAAALAAIDTMEQHDLNGRARHIEEL 357 Query: 356 LRNELMKLPSD-------VVTAVRGKGLLNAIVIKE--TKDWDA------WKVCLRLRDN 400 +L +L ++ VV +RG+G + AI + + +K+ +A CL+ Sbjct: 358 ALGKLRELAAELSAGGGSVVGDIRGRGAMLAIELVQPGSKEPNAELTKAVAAACLK-EGV 416 Query: 401 GLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTI 436 +L T+G++IR PPLVI ++ L + +E++ I Sbjct: 417 IILTCGTYGNVIRLLPPLVISDELLIDGLEVLAAAI 452 >5GHG-A nrPDB Length = 456 Score = 143 bits (360), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 118/442 (26%), Positives = 195/442 (44%), Gaps = 56/442 (12%) Query: 46 REYKYGAHNYHPL-------PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIV 98 R+ +Y H+Y P+ +ERG GIY+ DV G++Y + +S +V G P++ Sbjct: 11 RDIRYHLHSYTDAVRLEAEGPLVIERGDGIYVEDVSGKRYIEAMSGLLSVGVGFSEPRLA 70 Query: 99 NALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPM------NTGVEAGETACKL 152 A Q+ KL Y + G + KL + V PM N+G EA +T KL Sbjct: 71 EAAARQMKKLPFYHTFSYRS-HGPVIDLAEKLVSMAPV-PMSKAYFTNSGSEANDTVVKL 128 Query: 153 ARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGF--------------- 197 W + + + KI+ + G T+++ S + P ++ F Sbjct: 129 I--WYRSNALGEPERKKIISRKRGYHGVTIASASLTGLPNNHRSFDLPIDRILHTGCPHF 186 Query: 198 ------GPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRE 251 G F ++L L A +AAF+ EP+ G GVVVP Y V+ Sbjct: 187 YREGQAGESEEQFATRLADELEQLIIAEGPHTIAAFIGEPVMGAGGVVVPPKTYWEKVQA 246 Query: 252 LCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIM 311 + R+ +L IADE+ G RTG +++PDI+++ K LS P+SA L ++ + Sbjct: 247 VLKRYDILLIADEVICGFGRTGNLFGSQTFDMKPDILVMSKQLSSSYLPISAFLINERVY 306 Query: 312 LTIKPGEH-------GSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLP 364 I H G T G+P+ VA+ L ++EE +L NA G ++ L +L Sbjct: 307 APIAEESHKIGTLGTGFTASGHPVAAAVALENLAIIEERDLVANARDRGTYMQKRLRELQ 366 Query: 365 SD-VVTAVRGKGLLNAIVIKETKDWD---------AWKVCLRLRDNGLLAKPTHGDIIRF 414 +V VRG GL+ + + K K L++ G++++ GD + F Sbjct: 367 DHPLVGEVRGVGLIAGVELVTDKQAKTGLEPTGALGAKANAVLQERGVISR-AMGDTLAF 425 Query: 415 APPLVIKEDELRESIEIINKTI 436 PPL+I + ++ + + T+ Sbjct: 426 CPPLIINDQQVDTMVSALEATL 447 >6GWI-A nrPDB Length = 462 Score = 142 bits (358), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 122/439 (27%), Positives = 199/439 (45%), Gaps = 62/439 (14%) Query: 52 AHNYHPL----------PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNAL 101 AH+ HP + +G+Y+ D EG + D ++ VN G+ ++V A Sbjct: 13 AHHLHPFTDFKALGEEGSRVVTHAEGVYIHDSEGNRILDGMAGLWCVNLGYGRRELVEAA 72 Query: 102 KSQVDKLTLTSRAFYNNVLG-------EYEEYITKLFNYH--KVLPMNTGVEAGETACKL 152 +Q+++L +YN E + L H +V +G EA +T ++ Sbjct: 73 TAQLEQLP-----YYNTFFKTTHPPAVRLAEKLCDLAPAHINRVFFTGSGSEANDTVLRM 127 Query: 153 ARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDII--PY- 209 R++ + +KG Q K I+ + G TL+ +S + GP +PG I PY Sbjct: 128 VRRY-WALKG-QPDKQWIIGRENAYHGSTLAGMSLGGMAPMHAQGGPCVPGIAHIRQPYW 185 Query: 210 ----NDLP----------ALERA---LQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVREL 252 D+ ALE L + VAAF+ EP+QG G ++P Y V+++ Sbjct: 186 FGEGRDMSPEAFGQTCAEALEEKILELGEEKVAAFIAEPVQGAGGAIMPPESYWPAVKKV 245 Query: 253 CTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIML 312 ++ +L +ADE+ G R G W + + PD++ + K LS G P+ VL D + Sbjct: 246 LAKYDILLVADEVICGFGRLGEWFGSQHYGLEPDLMPIAKGLSSGYLPIGGVLVGDRVAE 305 Query: 313 TI--KPGE--HGSTYGGNPLGCRVAIAALEVLEEENLAENA-DKLGIILRNELMKLPSD- 366 T+ + GE HG TY G+P VA+ LE+LE E + + D LG L L Sbjct: 306 TLIEEGGEFFHGFTYSGHPTCAAVALKNLELLEAEGVVDRVRDDLGPYLAERWASLVDHP 365 Query: 367 VVTAVRGKGLLNAIVI--------KETKDWDAWKVCLRL-RDNGLLAKPTHGDIIRFAPP 417 +V R GL+ A+ + + K A +C L NGL+ + GD + +PP Sbjct: 366 IVGEARSLGLMGALELVADKTTGQRFDKSLGAGNLCRDLCFANGLVMRSV-GDTMIISPP 424 Query: 418 LVIKEDELRESIEIINKTI 436 LVI+ +E+ E +E+ + + Sbjct: 425 LVIRREEIDELVELARRAL 443 >5TI8-A nrPDB Length = 474 Score = 141 bits (356), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 115/413 (27%), Positives = 198/413 (47%), Gaps = 43/413 (10%) Query: 62 LERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLG 121 + + +G+YLWD EG K D ++ +N G+ ++ Q+ +L + F+ Sbjct: 58 ITKAEGVYLWDSEGNKILDGMAGLWCMNVGYGRKELAEVAYKQMLELPYYN-LFFQTAHP 116 Query: 122 EYEEYITKLFN-----YHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGN 176 E + + + V +G E+ +T ++ R + +++KG K + K+V N Sbjct: 117 PALELAKAIADIAPEGMNHVFFTGSGSESNDTVLRMVRHY-WSIKG--KPQKKVVIGRWN 173 Query: 177 -FWGRTLSAISSSTDPTSYDGFGPFMPGFDII--PY-----NDLPA----------LERA 218 + G T++ +S + +PG I PY D+ A LE+ Sbjct: 174 GYHGSTVAGVSLGGMKALHSQGDLPIPGIVHIAQPYWYGEGGDMSAEEFGVWAAEQLEKK 233 Query: 219 L---QDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRW 275 + + NVAAF+ EPIQG GV+VP Y +RE+ ++++LFIADE+ G RTG W Sbjct: 234 ILEVGEENVAAFIAEPIQGAGGVIVPPDTYWPKIREILAKYEILFIADEVICGFGRTGEW 293 Query: 276 LAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRV 332 Y PD++ + K L+ G P+ V+ D+I+ T+ G HG TY G+P+ V Sbjct: 294 FGSQYYGNAPDLMPIAKGLTSGYIPMGGVIVRDEIVDTLNEGGEFYHGFTYSGHPVAAAV 353 Query: 333 AIAALEVLEEENLAENAD-KLGIILRNELMKLPSD-VVTAVRGKGLLNAIVI---KETKD 387 A+ + +L EE + E + L+ +L +V RG G++ A+ + K+T++ Sbjct: 354 ALENIRILREEKIVETVKAETAPYLQKRWQELADHPLVGEARGVGMVGALELVKNKKTRE 413 Query: 388 WDAWKVCLRLRD----NGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTI 436 V + R+ NGL+ + GD + +PPLVI + E+ E I + K + Sbjct: 414 RFENGVGMLCREHCFRNGLIMRAV-GDTMIISPPLVITKPEIDELITLARKCL 465 >4BQ0-A nrPDB Length = 448 Score = 140 bits (354), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 119/441 (26%), Positives = 197/441 (44%), Gaps = 46/441 (10%) Query: 37 PPTSDDIFEREY--KYGAH-NYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHC 93 PP S ++ R + + A+ N+ P + +G +L D +GRK +D LS GH Sbjct: 9 PPVSSELNLRAHWMPFSANRNFQKDPRIIVAAEGSWLTDDKGRKVYDSLSGLWTCGAGHS 68 Query: 94 HPKIVNALKSQVDKLTLTSRAFYNNVLG-EYEEYITKLF--NYHKVLPMNTGVEAGETAC 150 +I A+ Q+ L + Y + L + E I L + V +G E +T+ Sbjct: 69 RKEIQEAVARQLGTLDYSPGFQYGHPLSFQLAEKIAGLLPGELNHVFFTGSGSECADTSI 128 Query: 151 KLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYN 210 K+AR + + +KG Q K K++ A + G ++ S + FG M D +P+ Sbjct: 129 KMARAY-WRLKG-QPQKTKLIGRARGYHGVNVAGTSLGGIGGNRKMFGQLMD-VDHLPHT 185 Query: 211 DLP--ALERALQD-------------------PNVAAFMVEPIQGEAGVVVPDPGYLMGV 249 P A R + N+AA +VEP+ G AGV+VP GYL + Sbjct: 186 LQPGMAFTRGMAQTGGVELANELLKLIELHDASNIAAVIVEPMSGSAGVLVPPVGYLQRL 245 Query: 250 RELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDD 309 RE+C +H +L I DE+ T R G + +Y V PD++ + K ++ G P+ AV+ + Sbjct: 246 REICDQHNILLIFDEVITAFGRLGTYSGAEYFGVTPDLMNVAKQVTNGAVPMGAVIASSE 305 Query: 310 IMLTIKPG---------EHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNEL 360 I T HG TY +P+ C +AAL++L +NL + + +L L Sbjct: 306 IYDTFMNQALPEHAVEFSHGYTYSAHPVACAAGLAALDILARDNLVQQSAELAPHFEKGL 365 Query: 361 MKLP-SDVVTAVRGKGLLNAIVIKETKDWD----AWKVCLRLRDNGLLAKPTHGDIIRFA 415 L + V +R GL AI I +D D ++ ++L G + GD ++F Sbjct: 366 HGLQGAKNVIDIRNCGLAGAIQIA-PRDGDPTVRPFEAGMKLWQQGFYVR-FGGDTLQFG 423 Query: 416 PPLVIKEDELRESIEIINKTI 436 P + +EL + + + + Sbjct: 424 PTFNARPEELDRLFDAVGEAL 444 >3I4J-A nrPDB Length = 430 Score = 139 bits (349), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 102/345 (29%), Positives = 168/345 (48%), Gaps = 32/345 (9%) Query: 41 DDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNA 100 ++F R K P PVA+ RG+G++L+D GR+Y D S N GH ++ Sbjct: 2 SNVFYRSSK-------PYPVAV-RGEGVFLYDDAGRRYLDGSSGALVANIGHGRAEVGER 53 Query: 101 LKSQVDKLTLT-SRAFYNNVLGEYEEYITKLFNY--HKVLPMNTGVEAGETACKLARKWG 157 + +Q +L F ++VL EY + + + ++ G EA E+A KLAR+ Sbjct: 54 MAAQAARLPFVHGSQFSSDVLEEYAGRLARFVGLPTFRFWAVSGGSEATESAVKLARQ-- 111 Query: 158 YTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFM--PGFDIIPYND---- 211 Y V+ + + K++ ++ G +L ++++S + + P M + +P D Sbjct: 112 YHVERGEPGRFKVITRVPSYHGASLGSLAASGMGARRELYTPLMRPEAWPKLPKPDPARN 171 Query: 212 -------LPALERALQDPNVAAFMVEPIQGEA-GVVVPDPGYLMGVRELCTRHQVLFIAD 263 L AL VAAFM EP+ G + + P PGY VR++C ++FIAD Sbjct: 172 GAEDAEGLRALLEREGPETVAAFMAEPVVGASDAALAPAPGYYERVRDICDEAGIIFIAD 231 Query: 264 EIQTGLARTGRWLAVD-YENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE---- 318 E+ +G+ R G LA+ + V PDI +LGK L+ G P++ +L + T+ G Sbjct: 232 EVMSGMGRCGSPLALSRWSGVTPDIAVLGKGLAAGYAPLAGLLAAPQVYETVMGGSGAFM 291 Query: 319 HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKL 363 HG TY G+P+ ++ L+++E E+L A + G L L L Sbjct: 292 HGFTYAGHPVSVAAGLSVLDIVEREDLTGAAKERGAQLLAGLQAL 336 >5KQU-A nrPDB Length = 479 Score = 138 bits (347), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 125/457 (27%), Positives = 200/457 (43%), Gaps = 71/457 (15%) Query: 41 DDIFEREYKYGAHNYHP-----------LPVALERG-KGIYLWDVEGRKYFDFLSSYSAV 88 D +FE++ AH HP LP + G GI + D EGR+ D + V Sbjct: 25 DQLFEQDR---AHFMHPSTHAHDHASGALPGRIITGASGIRIRDHEGRELIDAFAGLYCV 81 Query: 89 NQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFN----------YHKVLP 138 N G+ ++ +A+ Q +L A+Y+ +G E I +L + KV Sbjct: 82 NIGYGRTEVADAIYKQAKEL-----AYYHTYVGHSTEAIIELSSRIIRDWAPAGMKKVYY 136 Query: 139 MNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFG 198 +G +A ET KL R + + QK KI+ + G + S + P+ + F Sbjct: 137 GLSGSDANETQIKLVRYYNNVLGRPQK--KKIISRQRGYHGSGIMTGSLTGLPSFHQHFD 194 Query: 199 PFMPGFD--IIPY------------------NDLPALERALQDPNVAAFMVEPIQGEAGV 238 + G + P+ ++L L A VAAF+ EP+ G G+ Sbjct: 195 LPVEGIKHTVCPHWYKAPAGMDEAAFVRYCADELEKLILAEGPDTVAAFIGEPVMGTGGI 254 Query: 239 VVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGL 298 +VP GY ++ + ++ VL IADE+ R G + +RPD++ K L+ Sbjct: 255 IVPPKGYWEAIQAVLNKYDVLLIADEVVCAFGRLGSKMGSQRYGMRPDLITTAKGLTSAY 314 Query: 299 YPVSAVLCDDDIMLTIKPGE-------HGSTYGGNPLGCRVAIAALEVLEEENLAENADK 351 P+SAV+ + + I+ HG TY G+P+ A+A L++LE ENL NA Sbjct: 315 APLSAVIVGEKVWDVIEKASQKEGAMGHGWTYSGHPICAAAALANLDILERENLTANAAD 374 Query: 352 LGIILRNELMKL--PSDVVTAVRGKGLLNAIVIKETKD----WD-----AWKVCLRLRDN 400 +G L L + +V VRG G+L A+ ++ +D KV ++ Sbjct: 375 VGAYLNQRLRETFEGHPLVGEVRGDGMLAALEFMADREARTPFDPALKVGPKVSAACLED 434 Query: 401 GLLAKPT-HGDIIRFAPPLVIKEDELRESIEIINKTI 436 G++A+ HGDI+ FAPPLV+ E E + I + Sbjct: 435 GMIARAMPHGDILGFAPPLVLTRAEADEIVGIAKAAV 471 >5G4J-A nrPDB Length = 446 Score = 134 bits (337), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 119/444 (26%), Positives = 208/444 (46%), Gaps = 55/444 (12%) Query: 26 TSVATKKTVQGPPTSDDIFEREY-KYGAHN--YHPLPVALERGKGIYLWDVEGRKYFDFL 82 TS T + P T++D+ R Y G H+ ++ P+ L G G++L D +G+ Y D Sbjct: 2 TSETTTTPSRVPQTANDLLARRYATIGPHSPLFYRQPLELVSGSGVWLTDAQGKVYLDGY 61 Query: 83 SSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFN--YHKVLPMN 140 ++ V GH +P + +A+ Q+ + L +R + N+ + EY E + F+ ++ N Sbjct: 62 NNVPHV--GHANPAVADAIYQQLLTVNLHTR-YLNSRVVEYAEALLSKFDGALERLFLTN 118 Query: 141 TGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPF 200 +G EA E A ++AR+ ++ + ++ G T S +T T ++ G Sbjct: 119 SGSEANELALRIARQ--------HTGNTGVLVSDFSYHGNTTSLAEITTGLTVHEPLGAH 170 Query: 201 -----MPGFDIIPYNDLPAL-ERALQDPN------------VAAFMVEPIQGEAGVVVPD 242 +P I D+P L E++L D + V+ F+ +P+ G++ Sbjct: 171 VRALRIPDVSGIAEVDVPVLLEQSLADVDAAIASLQAAGHGVSVFLFDPLFSTEGLLQLP 230 Query: 243 PGYLMGVRELCTRHQVLFIADEIQTGLARTGRWL-AVDYENVRPDIVLLGKALSGGLYPV 301 GY+ GV L I+DE+Q+G RTG + NV P++V +GK + G +P+ Sbjct: 231 SGYIEGVATRVRAAGGLVISDEVQSGFGRTGSGMWGYQMFNVEPELVTMGKPMGNG-HPI 289 Query: 302 SAVLCDDDIMLTIKPGEHG---STYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRN 358 AV+ +++ G H +T+ GNP+ +A L +++E+L AD+LG +R Sbjct: 290 GAVVTTAELLDEF--GRHNMFFNTFAGNPVSSAAGLAVLRYMDQEDLMAKADQLGKYIRK 347 Query: 359 ELMKLP--SDVVTAVRGKGLLNAIVIKETKDWDAWKVCLR------LRDNGLLAKPT--H 408 L + S V +VRG+GL I I E+ L +R+ G+L H Sbjct: 348 RLENIAQRSGNVGSVRGRGLFFGIDIIESDGSRNPAPALTKILIEDMRERGVLISRVGPH 407 Query: 409 GDIIRFAPPLVIKEDELRESIEII 432 ++++ PPLV RE +I+ Sbjct: 408 DNVLKMRPPLVFG----REHADIL 427 >1S09-A nrPDB Length = 429 Score = 132 bits (333), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 126/435 (28%), Positives = 207/435 (47%), Gaps = 52/435 (11%) Query: 39 TSDDIFEREYKYGAHNY----HPLPV-ALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHC 93 T+DD+ + ++ H Y PLPV + +G L +GR+ D +SS+ A G+ Sbjct: 2 TTDDL-AFDQRHILHPYTSMTSPLPVYPVVSAEGCELILSDGRRLVDGMSSWWAAIHGYN 60 Query: 94 HPKIVNALKSQVDKLTLTSRAFYNNVL-GEYEEYITKLFNY-----HKVLPMNTGVEAGE 147 HP++ A+KSQ+D + S + + E KL V ++G A E Sbjct: 61 HPQLNAAMKSQIDAM---SHVMFGGITHAPAIELCRKLVAMTPQPLECVFLADSGSVAVE 117 Query: 148 TACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTS-----YDGFGP--- 199 A K+A ++ + KG + + + + F G T A+S DP + + G+ P Sbjct: 118 VAMKMALQY-WQAKG--EARQRFLTFRNGFHGDTFGAMSVC-DPDNSMHSLWKGYLPENL 173 Query: 200 FMPG-----------FDIIPYNDLPALERALQDPNVAAFMVEPI-QGEAGVVVPDPGYLM 247 F P D++ + L A R +AA ++EPI QG G+ + P +L Sbjct: 174 FAPAPQSRMDGEWDERDMVGFARLMAAHRH----EIAAVIIEPIVQGAGGMRMYHPEWLK 229 Query: 248 GVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCD 307 +R++C R +L IADEI TG RTG+ A ++ + PDI+ LGKAL+GG +SA L Sbjct: 230 RIRKICDREGILLIADEIATGFGRTGKLFACEHAEIAPDILCLGKALTGGTMTLSATLTT 289 Query: 308 DDIMLTIKPGE-----HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMK 362 ++ TI GE HG T+ GNPL C A A+L +LE + + + + LR +L Sbjct: 290 REVAETISNGEAGCFMHGPTFMGNPLACAAANASLAILESGDWQQQVADIEVQLREQLAP 349 Query: 363 L-PSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIK 421 +++V VR G + V++ T + + + G+ +P G +I PP +I Sbjct: 350 ARDAEMVADVRVLGAIG--VVETTHPVNMAALQKFFVEQGVWIRP-FGKLIYLMPPYIIL 406 Query: 422 EDELRESIEIINKTI 436 +L+ +N+ + Sbjct: 407 PQQLQRLTAAVNRAV 421 >5KQT-A nrPDB Length = 479 Score = 132 bits (332), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 114/422 (27%), Positives = 182/422 (43%), Gaps = 70/422 (16%) Query: 66 KGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEE 125 G+ + D +GR+ D + VN G+ ++ +A+ Q +L A+Y+ +G E Sbjct: 59 SGVRIRDHQGRELLDAFAGLYCVNIGYGRLEVADAIHEQAKQL-----AYYHTYVGHASE 113 Query: 126 YITKL----------FNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAG 175 I +L KV +G +A ET KL R + + QK KI+ Sbjct: 114 AIIELSARIIRDWAPAGMKKVYYGLSGSDANETQVKLVRYYNNVLGRPQK--KKIISRQR 171 Query: 176 NFWGRTLSAISSSTDPTSYDGFGPFMPGFDI----IPYNDLPALERA------------- 218 + G S S G F FD+ + + P +A Sbjct: 172 GYHG-------SGIVTGSLTGLASFHQHFDLPVEGVKHTLCPHFYKAPAGMDEAAFVRHC 224 Query: 219 ---------LQDPN-VAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTG 268 + P+ VAAF+ EP+ G G++VP GY ++ + ++ VL IADE+ Sbjct: 225 AQELENLILAEGPDTVAAFIGEPVMGTGGIIVPPKGYWEAIQAVLAKYDVLLIADEVVCA 284 Query: 269 LARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE-------HGS 321 R G + +RPD++ K L+ P+SAV+ + + I HG Sbjct: 285 FGRLGDKMGSQRHAMRPDLITTAKGLTSAYAPLSAVIVGEKVWDVIDSASTREGAMGHGW 344 Query: 322 TYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKL--PSDVVTAVRGKGLLNA 379 TY G+P+ A+A L++LE EN+ NA +G L +L + +V VRG G+L A Sbjct: 345 TYSGHPICAAAALANLDILERENITANAADVGGYLNQQLRQAFEGHPLVGEVRGDGMLAA 404 Query: 380 IVIKETKD----WDAW-----KVCLRLRDNGLLAKPT-HGDIIRFAPPLVIKEDELRESI 429 + ++ +DA KV + G++A+ HGDI+ FAPPLV+ E E + Sbjct: 405 LEFMADREARTPFDAALKVGPKVSAACLERGMIARAMPHGDILGFAPPLVLSRAEADEVV 464 Query: 430 EI 431 I Sbjct: 465 GI 466 >2CFB-A nrPDB Length = 411 Score = 131 bits (329), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 96/305 (31%), Positives = 148/305 (48%), Gaps = 21/305 (6%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLT-LTSRAFYN 117 P+ + KG ++WDV+G +Y D++ S+ GH HP++++AL + ++K T + Sbjct: 19 PIVFDHVKGAHIWDVDGNQYIDYVGSWGPAIVGHAHPEVIDALHAALEKGTSFGAPCLLE 78 Query: 118 NVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNF 177 N+L E I + + V +N+G EA +L R + K I K++ A F Sbjct: 79 NILAEM--VIAAVPSVEMVRFVNSGTEACMAVLRLMRAYTQREKVI-KFEGCYHGHADMF 135 Query: 178 WGRTLSAISSSTDPTSYDGFGPFMP-----GFDIIPYNDLPALERAL-QDPN-VAAFMVE 230 + S +++ P S P +P PYNDL A+ R Q PN +A ++E Sbjct: 136 LVKAGSGVATLGLPDS-----PGVPKATTAATLTAPYNDLEAVSRLFEQYPNDIAGVILE 190 Query: 231 PIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLL 290 P+ G AG + PD G+L G+REL ++ L + DE+ TG R A + V PD+ L Sbjct: 191 PVVGNAGFIPPDAGFLEGLRELTKQYGALLVFDEVMTGF-RIAYGGAQEKFGVTPDLTTL 249 Query: 291 GKALSGGLYPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAALEVLEEENLAE 347 GK + GGL PV A +IM + P T GNPL I LE+L E Sbjct: 250 GKVIGGGL-PVGAYGGRAEIMKMVAPAGPVYQAGTLSGNPLAMTAGIKTLEILSRPGSYE 308 Query: 348 NADKL 352 + D++ Sbjct: 309 HLDRI 313 >3GJU-A nrPDB Length = 460 Score = 130 bits (327), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 122/449 (27%), Positives = 184/449 (40%), Gaps = 75/449 (16%) Query: 41 DDIFEREYKYGAHNYHPLPV-ALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVN 99 D F G H P + G+G+ +WD GRK D + VN G+ KI + Sbjct: 15 DHFFHPSTHMGTHARGESPTRIMAGGEGVTVWDNNGRKSIDAFAGLYCVNVGYGRQKIAD 74 Query: 100 ALKSQVDKLTLTSRAFYNNVLGEYEEYITKLF---------NYHKVLPMNTGVEAGETAC 150 A+ +Q L A+Y+ +G E L +V +G +A ET Sbjct: 75 AIATQAKNL-----AYYHAYVGHGTEASITLAKMIIDRAPKGMSRVYFGLSGSDANETNI 129 Query: 151 KLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDI---- 206 KL W Y + K KI+ + G S S G F FD+ Sbjct: 130 KLI--WYYNNVLGRPEKKKIISRWRGYHG-------SGVMTGSLTGLDLFHNAFDLPRAP 180 Query: 207 -----IPY-------------------NDLPALERALQDPNVAAFMVEPIQGEAGVVVPD 242 PY + L + A +AAF+ EPI G G+V P Sbjct: 181 VLHTEAPYYFRRTDRSMSEEQFSQHCADKLEEMILAEGPETIAAFIGEPILGTGGIVPPP 240 Query: 243 PGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVS 302 GY ++ + ++ VL +ADE+ TG R G D+ ++PD++ + K L+ P+S Sbjct: 241 AGYWEKIQAVLKKYDVLLVADEVVTGFGRLGTMFGSDHYGIKPDLITIAKGLTSAYAPLS 300 Query: 303 AVLCDDDIMLTIKPGE-------HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGII 355 V+ D + + G HG TY +P+ +A LE+++E +L NA + G Sbjct: 301 GVIVADRVWQVLVQGSDKLGSLGHGWTYSAHPICVAAGVANLELIDEMDLVTNAGETGAY 360 Query: 356 LRNELMKLPS--DVVTAVRGKGLLNAIVIKETKD----WDAW-----KVCLRLRDNGLLA 404 R EL K V VRG G+L A+ KD +DA +V L +G++ Sbjct: 361 FRAELAKAVGGHKNVGEVRGDGMLAAVEFVADKDDRVFFDASQKIGPQVATALAASGVIG 420 Query: 405 KPT-HGDIIRFAPPLVIKEDELRESIEII 432 + GDI+ FAPPL + RE +I+ Sbjct: 421 RAMPQGDILGFAPPLCLT----REQADIV 445 >4GRX-A nrPDB Length = 465 Score = 130 bits (326), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 116/422 (27%), Positives = 190/422 (45%), Gaps = 52/422 (12%) Query: 60 VALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNV 119 V + G+G Y+ DV GR+Y D S + G H ++ A K+Q D+ AF+ + Sbjct: 43 VVVTHGEGPYIVDVHGRRYLDANSGLWNMVAGFDHKGLIEAAKAQYDRFP-GYHAFFGRM 101 Query: 120 LGEYEEYITKL-----FNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAA 174 + KL F+ +V N+G EA +T K+ W + K KI+ Sbjct: 102 SDQTVMLSEKLVEVSPFDNGRVFYTNSGSEANDTMVKML--WFLHAAEGKPQKRKILTRW 159 Query: 175 GNFWGRTLSAISSSTDPTSYDG-FGPFMPGFDIIP------YND--------LPALERAL 219 + G ++A+S+S Y+ FG +PGF + Y + + L R L Sbjct: 160 NAYHG--VTAVSASMTGKPYNSVFGLPLPGFIHLTCPHYWRYGEEGETEAQFVARLAREL 217 Query: 220 QDP-------NVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLART 272 +D +A F EP+ G GV+ P GY + + ++ + I+DE+ G RT Sbjct: 218 EDTITREGADTIAGFFAEPVMGAGGVIPPAKGYFQAILPILRKYDIPMISDEVICGFGRT 277 Query: 273 GR-WLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDI-------MLTIKPGEHGSTYG 324 G W + Y + PD ++ K L+ G +P+ AV+ D+ + I+ HG T Sbjct: 278 GNTWGCLTY-DFMPDAIISSKNLTAGFFPMGAVILGPDLAKRVEAAVEAIEEFPHGFTAS 336 Query: 325 GNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDV-VTAVRGKGL---LNAI 380 G+P+GC +A+ A++V+ E LAEN +L L ++ + RG G L A+ Sbjct: 337 GHPVGCAIALKAIDVVMNEGLAENVRRLAPRFEAGLKRIADRPNIGEYRGIGFMWALEAV 396 Query: 381 VIKETKD-WDA-----WKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINK 434 K TK +DA ++ D GL+ +P G I PP ++ E ++ E E + K Sbjct: 397 KDKPTKTPFDANLSVSERIANTCTDLGLICRPL-GQSIVLCPPFILTEAQMDEMFEKLEK 455 Query: 435 TI 436 + Sbjct: 456 AL 457 >4BA4-A nrPDB Length = 459 Score = 129 bits (325), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 115/442 (26%), Positives = 190/442 (42%), Gaps = 62/442 (14%) Query: 52 AHNYHPL----------PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNAL 101 AH+ HP + RG+G+YLWD EG K D ++ VN G+ A Sbjct: 16 AHHLHPFTDTASLNQAGARVMTRGEGVYLWDSEGNKIIDGMAGLWCVNVGYGRKDFAEAA 75 Query: 102 KSQVDKLTLTSRAFYNNVLGEYEEYITKLFN---------YHKVLPMNTGVEAGETACKL 152 + Q+++L FYN + +L + + +V N+G E+ +T ++ Sbjct: 76 RRQMEEL-----PFYNTFFKTTHPAVVELSSLLAEVTPAGFDRVFYTNSGSESVDTMIRM 130 Query: 153 ARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGF-------- 204 R++ + V+G + K ++ + G T+ S ++ +PG Sbjct: 131 VRRY-WDVQG-KPEKKTLIGRWNGYHGSTIGGASLGGMKYMHEQGDLPIPGMAHIEQPWW 188 Query: 205 -----DIIPYNDLPALERALQDP-------NVAAFMVEPIQGEAGVVVPDPGYLMGVREL 252 D+ P R L++ VAAF+ EPIQG GV+VP Y + + Sbjct: 189 YKHGKDMTPDEFGVVAARWLEEKILEIGADKVAAFVGEPIQGAGGVIVPPATYWPEIERI 248 Query: 253 CTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIML 312 C ++ VL +ADE+ G RTG W + +PD+ K LS G P+ AV + Sbjct: 249 CRKYDVLLVADEVICGFGRTGEWFGHQHFGFQPDLFTAAKGLSSGYLPIGAVFVGKRVAE 308 Query: 313 TIKPG---EHGSTYGGNPLGCRVAIAALEVLEEENLAENA-DKLGIILRNELMKLPS--D 366 + G HG TY G+P+ VA A + L +E + + D +G ++ + S + Sbjct: 309 GLIAGGDFNHGFTYSGHPVCAAVAHANVAALRDEGIVQRVKDDIGPYMQKRWRETFSRFE 368 Query: 367 VVTAVRGKGLLNAIVIKETKDW-----DAWKVCLRLRD----NGLLAKPTHGDIIRFAPP 417 V VRG G++ A + + K D ++ RD N L+ + GD I APP Sbjct: 369 HVDDVRGVGMVQAFTLVKNKAKRELFPDFGEIGTLCRDIFFRNNLIMRAC-GDHIVSAPP 427 Query: 418 LVIKEDELRESIEIINKTILSF 439 LV+ E+ E + + + + F Sbjct: 428 LVMTRAEVDEMLAVAERCLEEF 449 >5M46-A nrPDB Length = 440 Score = 126 bits (317), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 118/435 (27%), Positives = 206/435 (47%), Gaps = 45/435 (10%) Query: 35 QGPPTSDDIFEREYKY--GAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGH 92 QGP + +++ R+ P+A+ G+G L + +GR+ D ++ A + G+ Sbjct: 1 QGPAMAGNLYGRDGAAIGSLQKLRFFPLAVAGGQGARLVEEDGRELIDLSGAWGAASLGY 60 Query: 93 CHPKIVNAL-KSQVDKLTLTSRAFYNNVLGEYEEYITKLF---NYHKVLPMNTGVEAGET 148 HP I+ A+ ++ + + + N E +T F HKV ++G +A E Sbjct: 61 GHPAIIEAVSRAAANPAGASILSASNAPAVALAERLTASFPGRGTHKVWFGHSGSDANEA 120 Query: 149 ACK-LARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSS-----TDPTSYDGFGPFMP 202 A + + R G T ++ G + G T+ +++ S D DG +P Sbjct: 121 AYRAITRATGRT---------GVIAFIGAYHGCTVGSMAFSGHSVQADAAKADGL-ILLP 170 Query: 203 GFD-IIPYNDLP------AL--ERALQDP--NVAAFMVEPIQGEAGVVVPDPGYLMGVRE 251 D PY D P AL ER P ++AA +EPIQ + G++VP G+L + Sbjct: 171 YPDPYRPYQDDPTGDAVLALLKERLAAVPAGSIAAAFIEPIQSDGGLIVPPDGFLRKFAD 230 Query: 252 LCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIM 311 +C H + + DE++ GLAR+GR ++E PDI++L GG P+SAV+ +I Sbjct: 231 ICRAHGISVVCDEVKVGLARSGRLHCFEHEGFVPDILVL-GKGLGGGLPLSAVIAPAEI- 288 Query: 312 LTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPS--DVVT 369 L T GNP+ +A LE +E ENL A++ G +LR L +L +++ Sbjct: 289 LDCASAFAMQTLHGNPVCAAAGLAVLETIEAENLTTAAERKGKLLREGLARLAERHELIG 348 Query: 370 AVRGKGLLNAIVI------KETKDWDAWKVCLRLRDNGLLAK--PTHGDIIRFAPPLVIK 421 +RG+GL + + +E + K+ R + GL+ +G+++ PPL + Sbjct: 349 DIRGRGLACGVELVRNRQSREPARAETAKLIYRAYELGLVLYYVGMNGNVLEMTPPLTMT 408 Query: 422 EDELRESIEIINKTI 436 EDE+R ++ ++++ Sbjct: 409 EDEVRHAVNLLDQAF 423 >4WYG-A nrPDB Length = 457 Score = 126 bits (317), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 109/376 (28%), Positives = 174/376 (46%), Gaps = 35/376 (9%) Query: 77 KYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLF----- 131 + D +SS+ GH HP + AL +Q L + + + + E + KL Sbjct: 76 EVLDAMSSWWTAIHGHGHPALDQALTTQ---LRVMNHVMFGGLTHEPAARLAKLLVDITP 132 Query: 132 -NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSS-- 188 V ++G + E A K+A ++ + +G+ K +++ G + G T A+S Sbjct: 133 AGLDTVFFSDSGSVSVEVAAKMALQY-WRGRGLPG-KRRLMTWRGGYHGDTFLAMSICDP 190 Query: 189 --------TDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPI-QGEAGVV 239 TD + F P +P Y+ + A +AA +VEP+ QG G+ Sbjct: 191 HGGMHSLWTDVLAAQVFAPQVPRDYDPAYSAAFEAQLAQHAGELAAVVVEPVVQGAGGMR 250 Query: 240 VPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLY 299 DP YL +R++C R++VL I DEI TG RTG A D+ V PDI+ +GKAL+GG Sbjct: 251 FHDPRYLHDLRDICRRYEVLLIFDEIATGFGRTGALFAADHAGVSPDIMCVGKALTGGYL 310 Query: 300 PVSAVLCDDDIMLTIKPGE-----HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGI 354 ++A LC D+ TI G HG T+ NPL C V++A++E+L ++ +L Sbjct: 311 SLAATLCTADVAHTISAGAAGALMHGPTFMANPLACAVSVASVELLLGQDWRTRITELAA 370 Query: 355 ILRNEL---MKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDI 411 L L LP+ VT VR G + VI+ + D D G+ +P ++ Sbjct: 371 GLTAGLDTARALPA--VTDVRVCGAIG--VIECDRPVDLAVATPAALDRGVWLRPFR-NL 425 Query: 412 IRFAPPLVIKEDELRE 427 + PP + E+ + Sbjct: 426 VYAMPPYICTPAEITQ 441 >3A8U-X nrPDB Length = 449 Score = 126 bits (316), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 125/425 (29%), Positives = 195/425 (45%), Gaps = 46/425 (10%) Query: 54 NYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSR 113 N+ P + +G +L D +GRK +D LS GH +I A+ Q+ L + Sbjct: 28 NFLRDPRLIVAAEGSWLVDDKGRKVYDSLSGLWTCGAGHTRKEIQEAVAKQLSTLDYSPG 87 Query: 114 AFYNNVLG-EYEEYITKLF--NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKI 170 Y + L + E IT L N + V ++G E TA K+ R + + +KG Q K K+ Sbjct: 88 FQYGHPLSFQLAEKITDLTPGNLNHVFFTDSGSECALTAVKMVRAY-WRLKG-QATKTKM 145 Query: 171 VFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLP--ALER--------ALQ 220 + A + G ++ S + FG M D +P+ L A R AL Sbjct: 146 IGRARGYHGVNIAGTSLGGVNGNRKLFGQPMQDVDHLPHTLLASNAYSRGMPKEGGIALA 205 Query: 221 D-----------PNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGL 269 D N+AA VEP+ G AGV+VP GYL RE+C +H +L + DE+ TG Sbjct: 206 DELLKLIELHDASNIAAVFVEPLAGSAGVLVPPEGYLKRNREICNQHNILLVFDEVITGF 265 Query: 270 ARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTI--KPG-------EHG 320 RTG D V PD++ + K ++ G P+ AV+ +I T +P HG Sbjct: 266 GRTGSMFGADSFGVTPDLMCIAKQVTNGAIPMGAVIASTEIYQTFMNQPTPEYAVEFPHG 325 Query: 321 STYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLP-SDVVTAVRGKGLLNA 379 TY +P+ C +AAL +L++ENL ++ ++ L + + V +R GL A Sbjct: 326 YTYSAHPVACAAGLAALCLLQKENLVQSVAEVAPHFEKALHGIKGAKNVIDIRNFGLAGA 385 Query: 380 IVIKETKDWDA----WKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKE---DELRESI-EI 431 I I +D DA ++ + L G + GD ++F P K D L +++ E+ Sbjct: 386 IQIA-PRDGDAIVRPFEAGMALWKAGFYVR-FGGDTLQFGPTFNSKPQDLDRLFDAVGEV 443 Query: 432 INKTI 436 +NK + Sbjct: 444 LNKLL 448 >4GSA-A nrPDB Length = 432 Score = 125 bits (313), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 98/326 (30%), Positives = 153/326 (46%), Gaps = 21/326 (6%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLT-LTSRAFYN 117 P+ +R K Y WDV+G +Y D++ ++ GH HP+++ ALK ++K T + Sbjct: 40 PIVFDRVKDAYAWDVDGNRYIDYVGTWGPAICGHAHPEVIEALKVAMEKGTSFGAPCALE 99 Query: 118 NVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNF 177 NVL E + + V +N+G EA +L R + K I K++ A F Sbjct: 100 NVLAEMVN--DAVPSIEMVRFVNSGTEACMAVLRLMRAYTGRDK-IIKFEGCYHGHADMF 156 Query: 178 WGRTLSAISSSTDPTSYDGFGPFMPGFD-----IIPYNDLPALERAL-QDPN-VAAFMVE 230 + S +++ P+S P +P PYNDL A++ ++P +A ++E Sbjct: 157 LVKAGSGVATLGLPSS-----PGVPKKTTANTLTTPYNDLEAVKALFAENPGEIAGVILE 211 Query: 231 PIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLL 290 PI G +G +VPD G+L G+RE+ H L + DE+ TG R + V PD+ L Sbjct: 212 PIVGNSGFIVPDAGFLEGLREITLEHDALLVFDEVMTGF-RIAYGGVQEKFGVTPDLTTL 270 Query: 291 GKALSGGLYPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAALEVLEEENLAE 347 GK + GGL PV A +IM + P T GNPL I LE+L + E Sbjct: 271 GKIIGGGL-PVGAYGGKREIMQLVAPAGPMYQAGTLSGNPLAMTAGIKTLELLRQPGTYE 329 Query: 348 NADKLGIILRNELMKLPSDVVTAVRG 373 D++ L + L+ + + A G Sbjct: 330 YLDQITKRLSDGLLAIAQETGHAACG 355 >3FCR-A nrPDB Length = 458 Score = 123 bits (308), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 116/427 (27%), Positives = 181/427 (42%), Gaps = 73/427 (17%) Query: 62 LERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLG 121 ++ G+++ D +G K D + VN G+ +I A+ Q +L A+Y++ +G Sbjct: 36 IKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIAEAIADQAREL-----AYYHSYVG 90 Query: 122 EYEEYITKLF---------NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVF 172 E L N KV G +A ET KL W Y + K KI+ Sbjct: 91 HGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETNVKLI--WYYNNILGRPEKKKIIS 148 Query: 173 AAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDI---------IPY-------------- 209 + G L S G F FD+ PY Sbjct: 149 RWRGYHGSGLVT-------GSLTGLELFHKKFDLPVEQVIHTEAPYYFRREDLNQTEEQF 201 Query: 210 -----NDLPAL-ERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIAD 263 +L AL ER D +AAF+ EPI G G+V P GY ++ + +H +L +AD Sbjct: 202 VAHCVAELEALIEREGAD-TIAAFIGEPILGTGGIVPPPAGYWEAIQTVLNKHDILLVAD 260 Query: 264 EIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE----- 318 E+ TG R G D+ + PDI+ + K L+ P+S + D + ++ G Sbjct: 261 EVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSDKVWKVLEQGTDENGP 320 Query: 319 --HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSD--VVTAVRGK 374 HG TY +P+G +A L++L+E NL NA ++G L + + S V VRG+ Sbjct: 321 IGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMAEALSQHANVGDVRGE 380 Query: 375 GLLNAIVIKETKD----WDAW-----KVCLRL--RDNGLLAKPTHGDIIRFAPPLVIKED 423 GLL A+ + +D +DA ++ +L +D + GDI+ FAPP + Sbjct: 381 GLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQGDILGFAPPFCLTRA 440 Query: 424 ELRESIE 430 E + +E Sbjct: 441 EADQVVE 447 >4E3Q-A nrPDB Length = 473 Score = 122 bits (307), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 110/422 (26%), Positives = 190/422 (45%), Gaps = 52/422 (12%) Query: 60 VALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNV 119 V + G+G Y+ DV GR+Y D S + G H +++A K+Q ++ AF+ + Sbjct: 51 VVVTHGEGPYIVDVNGRRYLDANSGLWNMVAGFDHKGLIDAAKAQYERFP-GYHAFFGRM 109 Query: 120 LGEYEEYITKL-----FNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAA 174 + KL F+ +V N+G EA +T K+ W + K KI+ Sbjct: 110 SDQTVMLSEKLVEVSPFDSGRVFYTNSGSEANDTMVKML--WFLHAAEGKPQKRKILTRW 167 Query: 175 GNFWGRTLSAISSSTDPTSYDG-FGPFMPGFDIIP------YND--------LPALERAL 219 + G ++A+S+S Y+ FG +PGF + Y + + L R L Sbjct: 168 NAYHG--VTAVSASMTGKPYNSVFGLPLPGFVHLTCPHYWRYGEEGETEEQFVARLAREL 225 Query: 220 QDP-------NVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLART 272 ++ +A F EP+ G GV+ P GY + + ++ + I+DE+ G RT Sbjct: 226 EETIQREGADTIAGFFAEPVMGAGGVIPPAKGYFQAILPILRKYDIPVISDEVICGFGRT 285 Query: 273 GR-WLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDI-------MLTIKPGEHGSTYG 324 G W V Y + PD ++ K L+ G +P+ AV+ ++ + I+ HG T Sbjct: 286 GNTWGCVTY-DFTPDAIISSKNLTAGFFPMGAVILGPELSKRLETAIEAIEEFPHGFTAS 344 Query: 325 GNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDV-VTAVRGKGL---LNAI 380 G+P+GC +A+ A++V+ E LAEN +L L + + RG G L A+ Sbjct: 345 GHPVGCAIALKAIDVVMNEGLAENVRRLAPRFEERLKHIAERPNIGEYRGIGFMWALEAV 404 Query: 381 VIKETKD-WD-----AWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINK 434 K +K +D + ++ D GL+ +P G + PP ++ E ++ E + + K Sbjct: 405 KDKASKTPFDGNLSVSERIANTCTDLGLICRPL-GQSVVLCPPFILTEAQMDEMFDKLEK 463 Query: 435 TI 436 + Sbjct: 464 AL 465 >3HMU-A nrPDB Length = 472 Score = 122 bits (305), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 111/432 (25%), Positives = 186/432 (43%), Gaps = 50/432 (11%) Query: 52 AHNYHPLPV----------ALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNAL 101 AH+ HP + R +G++L D EG + D ++ VN G+ ++ Sbjct: 21 AHHLHPFSANNALGEEGTRVITRARGVWLNDSEGEEILDAMAGLWCVNIGYGRDELAEVA 80 Query: 102 KSQVDKLTLTSRAFYNNVLGE--YEEYITKLF--NYHKVLPMNTGVEAGETACKLARKWG 157 Q+ +L + F + + + +L + + V G EA +T ++ R + Sbjct: 81 ARQMRELPYYNTFFKTTHVPAIALAQKLAELAPGDLNHVFFAGGGSEANDTNIRMVRTY- 139 Query: 158 YTVKGIQKYKAKIVFAAGNFWGRTL--SAISSSTDPTSYDGFGP----------FMPGFD 205 + KG Q K I+ + G T+ SA+ + G P + G D Sbjct: 140 WQNKG-QPEKTVIISRKNAYHGSTVASSALGGMAGMHAQSGLIPDVHHINQPNWWAEGGD 198 Query: 206 IIPYNDLPALERALQDP-------NVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQV 258 + P A R L++ VAAF+ EP+QG GV+V Y ++ +C ++ + Sbjct: 199 MDPEEFGLARARELEEAILELGENRVAAFIAEPVQGAGGVIVAPDSYWPEIQRICDKYDI 258 Query: 259 LFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE 318 L IADE+ G RTG W +RP I+ + K LS G P+ + D++ I E Sbjct: 259 LLIADEVICGFGRTGNWFGTQTMGIRPHIMTIAKGLSSGYAPIGGSIVCDEVAHVIGKDE 318 Query: 319 --HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSD--VVTAVRGK 374 HG TY G+P+ VA+ L +LEEEN+ ++ + E + +D +V + Sbjct: 319 FNHGYTYSGHPVAAAVALENLRILEEENILDHVRNVAAPYLKEKWEALTDHPLVGEAKIV 378 Query: 375 GLLNAIVIKETKDWDA---------WKVCL-RLRDNGLLAKPTHGDIIRFAPPLVIKEDE 424 G++ +I + K A +C R N L+ + GD + +PPLVI E Sbjct: 379 GMMASIALTPNKASRAKFASEPGTIGYICRERCFANNLIMRHV-GDRMIISPPLVITPAE 437 Query: 425 LRESIEIINKTI 436 + E I K++ Sbjct: 438 IDEMFVRIRKSL 449 >2JJG-A nrPDB Length = 449 Score = 119 bits (298), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 118/417 (28%), Positives = 174/417 (41%), Gaps = 52/417 (12%) Query: 62 LERGKGIYLWD-VEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTL-----TSRAF 115 L R G YL D + GR+Y D + ++ G P +V+ + + + ++ Sbjct: 39 LTRSGGSYLVDAITGRRYLDMFTFVASSALGMNPPALVDDREFHAELMQAALNKPSNSDV 98 Query: 116 YNNVLGEYEEYITKLFNYHKVLPMNTGVEAG----ETACKLARKWGY---TVKGIQ-KYK 167 Y+ + + E ++ LP VE G E A K A W GI Sbjct: 99 YSVAMARFVETFARVLG-DPALPHLFFVEGGALAVENALKAAFDWKSRHNQAHGIDPALG 157 Query: 168 AKIVFAAGNFWGRTLSAIS-SSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDP---- 222 +++ G F GR+ +S ++T PT F P FD P D P + L +P Sbjct: 158 TQVLHLRGAFHGRSGYTLSLTNTKPTITARF----PKFDW-PRIDAPYMRPGLDEPAMAA 212 Query: 223 ------------------NVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADE 264 ++A F+ EPIQGE G P + +RELC L I DE Sbjct: 213 LEAEALRQARAAFETRPHDIACFVAEPIQGEGGDRHFRPEFFAAMRELCDEFDALLIFDE 272 Query: 265 IQTGLARTGRWLAVDYENVRPDIVLLGK--ALSGGLYPVSAVLCDDDIMLTIKPGEHGST 322 +QTG TG A +V PDIV GK + G + D++ P ST Sbjct: 273 VQTGCGLTGTAWAYQQLDVAPDIVAFGKKTQVCGVMAGRRVDEVADNVFAV--PSRLNST 330 Query: 323 YGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSD---VVTAVRGKGLLNA 379 +GGN A LEV+E E L E A + G LR L +L +D VV RG+GL+ A Sbjct: 331 WGGNLTDMVRARRILEVIEAEGLFERAVQHGKYLRARLDELAADFPAVVLDPRGRGLMCA 390 Query: 380 IVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTI 436 + T D D ++ +L ++ P D +RF PPL + E+ +I + + Sbjct: 391 FSLPTTADRD--ELIRQLWQRAVIVLPAGADTVRFRPPLTVSTAEIDAAIAAVRSAL 445 >3K28-A nrPDB Length = 429 Score = 117 bits (293), Expect = 9e-27, Method: Compositional matrix adjust. Identities = 94/303 (31%), Positives = 146/303 (48%), Gaps = 27/303 (8%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLT-LTSRAFYN 117 P+ +ERGKG ++D++G +Y D++ S+ + GH + ++V ALK+ ++ T + Sbjct: 36 PLFMERGKGSKVYDIDGNEYIDYVLSWGPLIHGHANDRVVEALKAVAERGTSFGAPTEIE 95 Query: 118 NVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNF 177 N L + I ++ + V +N+G EA +A +LAR GYT + KI+ G + Sbjct: 96 NKLAKL--VIERVPSIEIVRMVNSGTEATMSALRLAR--GYTGRN------KILKFIGCY 145 Query: 178 WGRTLSAISSSTDPTSYDGFGPFMPGFD--------IIPYNDLPALERALQD--PNVAAF 227 G S + + + G P PG + YNDL +++ A + ++A Sbjct: 146 HGHGDSLLIKAGSGVATLGL-PDSPGVPEGVAKNTITVAYNDLESVKYAFEQFGDDIACV 204 Query: 228 MVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDI 287 +VEP+ G GVV P PG+L G+RE+ ++ L I DE+ TG R Y V PD+ Sbjct: 205 IVEPVAGNMGVVPPQPGFLEGLREVTEQNGALLIFDEVMTGF-RVAYNCGQGYYGVTPDL 263 Query: 288 VLLGKALSGGLYPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAALEVLEEEN 344 LGK + GGL PV A +IM + P T GNPL L L E+ Sbjct: 264 TCLGKVIGGGL-PVGAYGGKAEIMRQVAPSGPIYQAGTLSGNPLAMAAGYETLVQLTPES 322 Query: 345 LAE 347 E Sbjct: 323 YVE 325 >5HDM-A nrPDB Length = 434 Score = 117 bits (292), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 95/315 (30%), Positives = 150/315 (47%), Gaps = 21/315 (6%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLT-LTSRAFYN 117 PV ++ KG +WD++G +Y D++ S+ GH +++ AL + K T + Sbjct: 42 PVLIDSVKGSKMWDIDGNEYIDYVGSWGPAIIGHADDEVLAALAETMKKGTSFGAPCLLE 101 Query: 118 NVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNF 177 NVL E I+ + + V +N+G EA +LAR + K I K++ A F Sbjct: 102 NVLAEM--VISAVPSIEMVRFVNSGTEACMGVLRLARAFTNKEKFI-KFEGCYHGHANAF 158 Query: 178 WGRTLSAISSSTDPTSYDGFGPFMPGFDI-----IPYNDLPALER--ALQDPNVAAFMVE 230 + S +++ P S P +P PYNDL A+E+ A ++A ++E Sbjct: 159 LVKAGSGVATLGLPDS-----PGVPKAATSDTLTAPYNDLEAVEKLFAAHKGEISAVILE 213 Query: 231 PIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLL 290 P+ G +G + P P ++ G+R+L + VL I DE+ TG R A +Y + PD+ L Sbjct: 214 PVVGNSGFIPPTPEFINGLRQLTKDNGVLLIFDEVMTGF-RLAYGGAQEYFGITPDLTTL 272 Query: 291 GKALSGGLYPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAALEVLEEENLAE 347 GK + GGL PV A DIM + P T GNPL I L+ L++ E Sbjct: 273 GKIIGGGL-PVGAYGGRRDIMEMVAPAGPMYQAGTLSGNPLAMTAGIHTLKRLKQAGTYE 331 Query: 348 NADKLGIILRNELMK 362 DK+ L N +++ Sbjct: 332 YLDKITKELTNGILE 346 >3BS8-A nrPDB Length = 438 Score = 115 bits (289), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 97/318 (30%), Positives = 149/318 (46%), Gaps = 44/318 (13%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNN 118 P+ +ERGKG ++D++G +Y D++ S+ + GH + ++V +LK + Y Sbjct: 44 PIFMERGKGSKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAE---------YGT 94 Query: 119 VLG---EYEEYITKLF-----NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKI 170 G E E + KL + V +++G EA +A +LAR GYT + KI Sbjct: 95 SFGAPTEVENELAKLVIDRVPSVEIVRMVSSGTEATMSALRLAR--GYTGRN------KI 146 Query: 171 VFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFD--------IIPYNDLPALERALQD- 221 + G + G S + + + G P PG +PYNDL +++ A Q Sbjct: 147 LKFEGCYHGHGDSLLIKAGSGVATLGL-PDSPGVPEGIAKNTITVPYNDLESVKLAFQQF 205 Query: 222 -PNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDY 280 ++A +VEP+ G GVV P G+L G+R++ ++ L I DE+ TG R A Y Sbjct: 206 GEDIAGVIVEPVAGNMGVVPPQEGFLQGLRDITEQYGSLLIFDEVMTGF-RVDYNCAQGY 264 Query: 281 ENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAAL 337 V PD+ LGK + GGL PV A +IM I P T GNPL + L Sbjct: 265 FGVTPDLTCLGKVIGGGL-PVGAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETL 323 Query: 338 EVLEEE---NLAENADKL 352 + L + N + D+L Sbjct: 324 KQLTPDSYKNFIKKGDRL 341 >2EPJ-A nrPDB Length = 434 Score = 115 bits (289), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 91/305 (29%), Positives = 149/305 (48%), Gaps = 35/305 (11%) Query: 57 PLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFY 116 P P ++RG+G YL+ V+G + D + +Y + GH HP+++ A++ + +R + Sbjct: 37 PYPFYVKRGEGAYLYTVDGARIVDLVLAYGPLILGHKHPRVLEAVEEAL------ARGWL 90 Query: 117 NNVLGEYEEYIT-KLFNYHK----VLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIV 171 GE E + K+ Y K + +N+G EA TA +LAR GYT + + I+ Sbjct: 91 YGAPGEAEVLLAEKILGYVKRGGMIRFVNSGTEATMTAIRLAR--GYTGRDL------IL 142 Query: 172 FAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFD--------IIPYNDLPALERALQD-- 221 G + G + + ++ ++ G P G + PYND+ ALER + Sbjct: 143 KFDGCYHGSHDAVLVAAGSAAAHYGV-PTSAGVPEAVARLTLVTPYNDVEALERVFAEYG 201 Query: 222 PNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYE 281 +A +VEP+ AGV+ P +L ++ L L I DE+ TG R G A Y Sbjct: 202 DRIAGVIVEPVIANAGVIPPRREFLAALQRLSRESGALLILDEVVTGF-RLGLEGAQGYF 260 Query: 282 NVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAALE 338 N+ DI++LGK + GG +PV AV ++M + P + T+ +P+ +A L+ Sbjct: 261 NIEGDIIVLGKIIGGG-FPVGAVAGSREVMSLLTPQGKVFNAGTFNAHPITMAAGLATLK 319 Query: 339 VLEEE 343 LEEE Sbjct: 320 ALEEE 324 >2E7U-A nrPDB Length = 424 Score = 115 bits (288), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 95/303 (31%), Positives = 143/303 (47%), Gaps = 38/303 (12%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDK-LTLTSRAFYN 117 P L RG+G Y+WD +G +Y D++ S+ + GH HPK++ ++ +++ LT + + Sbjct: 35 PPFLVRGEGAYVWDADGNRYLDYVMSWGPLILGHAHPKVLARVRETLERGLTFGAPSPLE 94 Query: 118 NVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNF 177 L + + + + +N+G EA +A +LAR GYT + IV GN+ Sbjct: 95 VALAKKVKRAYPFVDLVRF--VNSGTEATMSALRLAR--GYTG------RPYIVKFRGNY 144 Query: 178 WGR-------------TLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQ--DP 222 G TL SS+ P Y ++ YND L L+ Sbjct: 145 HGHADGLLVEAGSGALTLGVPSSAGVPEEYAKL------TLVLEYNDPEGLREVLKRRGE 198 Query: 223 NVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYEN 282 +AA + EP+ G AGV+VP +L + E + VL IADE+ TG R A + Sbjct: 199 EIAAIIFEPVVGNAGVLVPTEDFLKALHE-AKAYGVLLIADEVMTGF-RLAFGGATELLG 256 Query: 283 VRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIK---PGEHGSTYGGNPLGCRVAIAALEV 339 ++PD+V LGK L GGL P +A +IM + P T GNPL +A LE+ Sbjct: 257 LKPDLVTLGKILGGGL-PAAAYAGRREIMEKVAPLGPVYQAGTLSGNPLAMAAGLATLEL 315 Query: 340 LEE 342 LEE Sbjct: 316 LEE 318 >4E77-A nrPDB Length = 429 Score = 114 bits (285), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 96/318 (30%), Positives = 141/318 (44%), Gaps = 29/318 (9%) Query: 58 LPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYN 117 +P+ +ER G YL+DV+G+ Y D++ S+ + GH HP I A+ V++ Sbjct: 35 IPLFIERADGAYLFDVDGKAYIDYVGSWGPMILGHNHPAIRQAVIEAVERGLSFGAPTEM 94 Query: 118 NVLGEYEEYITKLFNYHKVLPM-NTGVEAGETACKLARKWGYT-------VKGIQKYKAK 169 V + + +T L ++ M N+G EA +A +LAR GYT +G A Sbjct: 95 EV--KMAQLVTDLVPTMDMVRMVNSGTEATMSAIRLAR--GYTGRDKIIKFEGCYHGHAD 150 Query: 170 IVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQD--PNVAAF 227 + TL +S PT F YNDL ++ +A + VA Sbjct: 151 CLLVKAGSGALTLGQPNSPGVPTD------FAKHTLTCTYNDLASVRQAFEQYPQEVACI 204 Query: 228 MVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDI 287 +VEP+ G + P P +L G+R LC L I DE+ TG R A DY +V PD+ Sbjct: 205 IVEPVAGNMNCIPPLPEFLPGLRALCDEFGALLIIDEVMTGF-RVALAGAQDYYHVIPDL 263 Query: 288 VLLGKALSGGLYPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAALEVLEE-- 342 LGK + GG+ PV A ++M + P T GNP+ A L + + Sbjct: 264 TCLGKIIGGGM-PVGAFGGRREVMNALAPTGPVYQAGTLSGNPIAMAAGFACLTEISQVG 322 Query: 343 --ENLAENADKLGIILRN 358 E L E D L LR+ Sbjct: 323 VYETLTELTDSLATGLRH 340 >4AOA-A nrPDB Length = 454 Score = 114 bits (284), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 104/387 (26%), Positives = 171/387 (44%), Gaps = 39/387 (10%) Query: 15 SRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKY--GAHN-----YHPLPVALERGKG 67 S H+++ A + A ++ P S FE + +Y GA++ Y P P+ + RG+G Sbjct: 19 SHMTHAAIDQALADAYRRFTDANPASQRQFEAQARYMPGANSRSVLFYAPFPLTIARGEG 78 Query: 68 IYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNA-LKSQVDKLTLTSRAFYNNVLGEYEEY 126 LWD +G +Y DF++ Y+A GH P+I +A +++ + LT +N + G Sbjct: 79 AALWDADGHRYADFIAEYTAGVYGHSAPEIRDAVIEAMQGGINLTG---HNLLEGRLARL 135 Query: 127 ITKLF-NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAI 185 I + F ++ N+G EA A A + + KIV +G + G L Sbjct: 136 ICERFPQIEQLRFTNSGTEANLMALTAALHF--------TGRRKIVVFSGGYHGGVL-GF 186 Query: 186 SSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQ--DPNVAAFMVEPIQGEAGVVVPDP 243 + PT+ PF F ++PYND ++ P +A +VEP+QG +G + P Sbjct: 187 GARPSPTTV----PF--DFLVLPYNDAQTARAQIERHGPEIAVVLVEPMQGASGCIPGQP 240 Query: 244 GYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSA 303 +L +RE T+ L + DE+ T +R + +R D+ LGK + GG+ A Sbjct: 241 DFLQALRESATQVGALLVFDEVMT--SRLAPHGLANKLGIRSDLTTLGKYIGGGM-SFGA 297 Query: 304 VLCDDDIMLTIKPG----EHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNE 359 D+M P H T+ N + A L L A + G LR Sbjct: 298 FGGRADVMALFDPRTGPLAHSGTFNNNVMTMAAGYAGLTKLFTPEAAGALAERGEALRAR 357 Query: 360 LMKLPSDVVTAVRGKG---LLNAIVIK 383 L L ++ A++ G L+NA ++ Sbjct: 358 LNALCANEGVAMQFTGIGSLMNAHFVQ 384 >6GIO-D nrPDB Length = 439 Score = 112 bits (279), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 114/406 (28%), Positives = 182/406 (44%), Gaps = 38/406 (9%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNN 118 P++L GKG L + GR D S G+ HP IV A++ V + S Y N Sbjct: 25 PLSLIGGKGNRLIEEGGRSILDLSGSAGPAALGYGHPAIVEAVEKSVRDMAGASLLLYPN 84 Query: 119 ----VLGEYEEYITKLFNYHKVLPMNTGVEAGETACKL---ARKWGYTVKGIQKYKAKIV 171 L E IT +V ++G +A + A ++ A K + I Y + Sbjct: 85 EAAVSLAEDLLRITPGNGERRVWFGHSGSDANDCAVRVLTAATKRSRIISFIGSYHGNLT 144 Query: 172 FAAGNFWGRTLSAISSSTDPTSYDGF------GPFMPGFDIIPYNDLPALERALQDP--N 223 + G +S ++ T G PF P F +L A P Sbjct: 145 GSMG------ISGHTAMTHTLPRPGVLLLPYPDPFRPRFSAEAVLELLDYHFATSCPPEQ 198 Query: 224 VAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENV 283 VAA +EPI + G+VVP P +L +++ C +H +L + DE++ GL RTG +E + Sbjct: 199 VAAVFIEPILSDGGLVVPPPAFLEALQDRCRKHGILVVVDEVKVGLGRTGLMHCFQHEGL 258 Query: 284 RPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEE 343 PD+V+ GK L GGL +SAV+ +M P T GNP+ A L +E + Sbjct: 259 EPDMVVFGKGLGGGLP-LSAVVGPQWVM-DHAPAFVLQTTAGNPVATAAGRAVLNTIERQ 316 Query: 344 NLAENADKLGIILRNELMKLPS--DVVTAVRGKGLLNAIVIKETKDWDAWKVC------- 394 LA+ ++++G I + L +L ++ VRG+GL AI + D + + Sbjct: 317 GLAQRSERVGGIFADRLRRLSDKHSIIGDVRGRGL--AIGVDLVSDRGSREPAPVTTTAK 374 Query: 395 LRLRDNGLLAKPTH----GDIIRFAPPLVIKEDELRESIEIINKTI 436 + R L A T+ +++ F PPL + E E+ E+ +I+++ I Sbjct: 375 IIYRGYQLGAAFTYVGLNANVLEFMPPLTLTEPEIDEAADIVDQAI 420 >5G0A-A nrPDB Length = 483 Score = 108 bits (269), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 100/378 (26%), Positives = 162/378 (42%), Gaps = 54/378 (14%) Query: 53 HNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTS 112 + Y P+P+ E +G YL +G + DF + VN G + K+ A+K +D+ Sbjct: 29 NEYQPVPI--ESTEGDYLIMPDGTRLLDFFNQLYCVNLGQKNQKVNAAIKEALDRYGFVW 86 Query: 113 RAFYNNVLGEYEEYITKLFNYHKVLP-----MNTGVEAGETACKLARKW----------- 156 + + + + I + + P ++TG EA ETA +AR + Sbjct: 87 DTYATDYKAKAAKIIIEDILGDEDWPGKVRFVSTGSEAVETALNIARLYTNRPLVVTREH 146 Query: 157 --------GYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIP 208 TV ++ Y++ +V G + S+ +SY+ P ++ Sbjct: 147 DYHGWTGGAATVTRLRSYRSGLV-------GENSESFSAQIPGSSYNSAVLMAPSPNMFQ 199 Query: 209 YNDLPALE-------------RALQD---PNVAAFMVEPIQGEAGVVVPDPGYLMGVREL 252 +D L+ R +++ VAA + E QG AG +P Y+ +R++ Sbjct: 200 DSDGNLLKDENGELLSVKYTRRMIENYGPEQVAAVITEVSQG-AGSAMPPYEYIPQIRKM 258 Query: 253 CTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDI-- 310 VL+I DE+ TG RTG+W + V+PDI+ +GK LS P AVL +I Sbjct: 259 TKELGVLWINDEVLTGFGRTGKWFGYQHYGVQPDIITMGKGLSSSSLPAGAVLVSKEIAA 318 Query: 311 MLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRN--ELMKLPSDVV 368 + E STY G+P+ A LEV+ EEN E A G +R+ EL++ + Sbjct: 319 FMDKHRWESVSTYAGHPVAMAAVCANLEVMMEENFVEQAKDSGEYIRSKLELLQEKHKSI 378 Query: 369 TAVRGKGLLNAIVIKETK 386 G GLL + I K Sbjct: 379 GNFDGYGLLWIVDIVNAK 396 >5I92-A nrPDB Length = 435 Score = 107 bits (268), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 83/290 (28%), Positives = 136/290 (46%), Gaps = 13/290 (4%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNN 118 P+ + +G Y+ D + ++Y D++ S+ + GH HP +++A++ Q+D Sbjct: 41 PLFFKHAEGAYVLDEDDKRYVDYVGSWGPMILGHSHPDVLDAVRRQLDHGLSYGAPTALE 100 Query: 119 VLGEYEEYITKLFNYHKVLPM-NTGVEAGETACKLARKWGYTVK-GIQKYKAKIVFAAGN 176 V E + + + +++ M ++G EA +A +LAR GYT + I K++ + + Sbjct: 101 V--EMADLVCSMVPSMEMVRMVSSGTEATMSAIRLAR--GYTGRDSIIKFEGCYHGHSDS 156 Query: 177 FWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQD--PNVAAFMVEPIQG 234 + S + P S F +P+ND+ A+ + L + VA +VEP+ G Sbjct: 157 LLVKAGSGALTFGVPNSPGVPAAFAKHTLTLPFNDIEAVRKTLGEVGKEVACIIVEPVAG 216 Query: 235 EAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKAL 294 V P PG+L G+RE C H V+ I DE+ TG R A Y V PD+ GK + Sbjct: 217 NMNCVPPAPGFLEGLREACDEHGVVLIFDEVMTGF-RVALGGAQAYYGVTPDLSTFGKII 275 Query: 295 SGGLYPVSAVLCDDDIMLTIK---PGEHGSTYGGNPLGCRVAIAALEVLE 341 GG+ PV A +IM I P T GNPL + L ++ Sbjct: 276 GGGM-PVGAFGGKREIMQQISPLGPVYQAGTLSGNPLAMAAGLTTLRLIS 324 >3I5T-A nrPDB Length = 476 Score = 103 bits (258), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 101/424 (23%), Positives = 178/424 (41%), Gaps = 61/424 (14%) Query: 62 LERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFY-NNVL 120 L +GIY+ +GR+ D + G+ +IV+A+ Q L S + + Sbjct: 40 LTHAEGIYVHTEDGRRLIDGPAGMWCAQVGYGRREIVDAMAHQAMVLPYASPWYMATSPA 99 Query: 121 GEYEEYITKLF--NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFW 178 E I L + +++ G A ++A + + + + QK +I+ + Sbjct: 100 ARLAEKIATLTPGDLNRIFFTTGGSTAVDSALRFSEFYNNVLGRPQK--KRIIVRYDGYH 157 Query: 179 GRTLSAISSSTDPTSYDGFGPFMPGFDI----IPYNDLPALERA---------------- 218 G T + + ++ P FDI I + P A Sbjct: 158 GSTALTAACTGRTGNW-------PNFDIAQDRISFLSSPNPRHAGNRSQEAFLDDLVQEF 210 Query: 219 ------LQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLART 272 L +AAF+ EPI GV++P GY + +C +H +L+I+DE+ TG R Sbjct: 211 EDRIESLGPDTIAAFLAEPILASGGVIIPPAGYHARFKAICEKHDILYISDEVVTGFGRC 270 Query: 273 GRWLAVD-YENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE--------HGSTY 323 G W A + V PDI+ K ++ G P+ + + ++ I GE +G TY Sbjct: 271 GEWFASEKVFGVVPDIITFAKGVTSGYVPLGGLAISEAVLARIS-GENAKGSWFTNGYTY 329 Query: 324 GGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDV--VTAVRGKGLLNAI- 380 P+ C A+A +E++E E + + A ++ L L D+ V R GL+ + Sbjct: 330 SNQPVACAAALANIELMEREGIVDQAREMADYFAAALASL-RDLPGVAETRSVGLVGCVQ 388 Query: 381 -VIKETK-DWDA------WKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEII 432 ++ T+ D A K+ R + GL+ +P GD+ +PPL+I ++ E + I+ Sbjct: 389 CLLDPTRADGTAEDKAFTLKIDERCFELGLIVRPL-GDLCVISPPLIISRAQIDEMVAIM 447 Query: 433 NKTI 436 + I Sbjct: 448 RQAI 451 >2ZUK-A nrPDB Length = 439 Score = 103 bits (257), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 101/410 (24%), Positives = 188/410 (45%), Gaps = 43/410 (10%) Query: 58 LPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYN 117 P+A+ G+G L + GR+ D ++ A + G+ HP IV A+ + + + Sbjct: 25 FPLAISGGRGARLIEENGRELIDLSGAWGAASLGYGHPAIVAAVSAAAANPAGATILSAS 84 Query: 118 NVLG-EYEEYITKLF---NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFA 173 N E + F HK+ ++G +A E A + K ++ ++ Sbjct: 85 NAPAVTLAERLLASFPGEGTHKIWFGHSGSDANEAAYRAIVK--------ATGRSGVIAF 136 Query: 174 AGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYND-----------------LPALE 216 AG + G T+ +++ S D G ++PY D L Sbjct: 137 AGAYHGCTVGSMAFSGHSVQADA--AKADGLILLPYPDPYRPYRNDPTGDAILTLLTEKL 194 Query: 217 RALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWL 276 A+ ++ A +EPIQ + G++VP G+L ++C H +L + DE++ GLAR+GR Sbjct: 195 AAVPAGSIGAAFIEPIQSDGGLIVPPDGFLRKFADICRAHGILVVCDEVKVGLARSGRLH 254 Query: 277 AVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAA 336 ++E PDI++L GG P+SAV+ +I L T GNP+ +A Sbjct: 255 CFEHEGFVPDILVL-GKGLGGGLPLSAVIAPAEI-LDCASAFAMQTLHGNPISAAAGLAV 312 Query: 337 LEVLEEENLAENADKLGIILRNELMKLPSD--VVTAVRGKGLLNAIVI------KETKDW 388 LE ++ ++L A++ G +LR+ L +L ++ +RG+GL + + +E Sbjct: 313 LETIDRDDLPAMAERKGRLLRDGLSELAKRHPLIGDIRGRGLACGMELVCDRQSREPARA 372 Query: 389 DAWKVCLRLRDNGLLAK--PTHGDIIRFAPPLVIKEDELRESIEIINKTI 436 + K+ R GL+ +G+++ F PPL I E ++ ++++++++ Sbjct: 373 ETAKLIYRAYQLGLVVYYVGMNGNVLEFTPPLTITETDIHKALDLLDRAF 422 >4ZM4-A nrPDB Length = 447 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 81/299 (27%), Positives = 128/299 (42%), Gaps = 30/299 (10%) Query: 57 PLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFY 116 PLP+ + G L DVE + D Y G+ ++++A+ Q K +T Sbjct: 39 PLPLVVRSAGGCLLRDVEDGEIIDLNMGYGPHLFGYADREVLDAVADQFAKGHMTG--LP 96 Query: 117 NNVLGEYEEYITKLF-NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAG 175 + + I +L +V N+G EA +A +LAR + +V G Sbjct: 97 HELDARAGALIAELVPGVEQVRFANSGTEAVASALRLARA--------TTGRTLVVTFEG 148 Query: 176 NFWGRTLSAISSSTDPTSYDGFGP--FMPG-FDIIP----------YNDLPALER--ALQ 220 ++ G + + + + +G P +PG +IP +ND AL A Sbjct: 149 HYHGWSETVLRAGKTALHMEGTRPTDVVPGALGMIPEALAHTVQLGWNDPDALRELFARD 208 Query: 221 DPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDY 280 +AA +VEP+ AGV+ P PG+L +REL R + + DE+ TG R R A + Sbjct: 209 GDRIAAVIVEPVLANAGVIPPAPGFLQLLRELTGRSGAMLVFDEVITGF-RVARGGAQER 267 Query: 281 ENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE--HGSTYGGNPLGCRVAIAAL 337 V PD+ +L + + GG +PV+A M + E H Y GN R +A L Sbjct: 268 YGVEPDLTVLSRVMGGG-FPVAAFGGRRHAMRMLASNEAHHAGVYAGNHAALRAVVAML 325 >5YKR-A nrPDB Length = 461 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 75/313 (23%), Positives = 127/313 (40%), Gaps = 41/313 (13%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNN 118 P+ ++ +G + D++G++Y DF S GH P + +A+ Q + + ++ Sbjct: 58 PLLVKEAQGARVTDIDGQQYVDFALGDSGAMFGHAQPAVADAIARQARRGSTLMLPTEDS 117 Query: 119 VLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFW 178 + E + + F + +A +L R + + K+V N+ Sbjct: 118 LWVGAE--LARRFGLPYWQVTTSATDANRFVLRLCR--------MLSGRDKVVVFNCNYH 167 Query: 179 GRTLSAISSSTDPTSYDGFGPFMPGFDIIP-------------YNDLPALERALQDPNVA 225 G S +D G +P + P +NDL ALE AL +VA Sbjct: 168 G------SVDESQVEFDAAGRMVPRAGVHPNGVRHATTTRLVEFNDLDALEAALAHGDVA 221 Query: 226 AFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRP 285 A + EP G+V P G+ G+REL RH V I DE T G + P Sbjct: 222 AVLTEPFMTNVGMVPPAEGFHAGLRELTRRHDVALIIDETHT--ISCGPAGYSGAHGLEP 279 Query: 286 DIVLLGKALSGGLYPVSAVLCDD-------DIMLTIKPGE--HGSTYGGNPLGCRVAIAA 336 D +LGK ++GG+ P + C ++ +PG+ + +GG G + +AA Sbjct: 280 DFFVLGKCIAGGI-PSAVWGCSQAQAERIWAVLPHFRPGQAINHFGFGGTLAGNALQLAA 338 Query: 337 LEVLEEENLAENA 349 + E + E+A Sbjct: 339 MRATFAEVMTEDA 351 >5DDW-A nrPDB Length = 523 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 60/226 (26%), Positives = 102/226 (45%), Gaps = 23/226 (10%) Query: 222 PNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYE 281 P VAA VEP++G +G+ P + L + DE+QTG+ RTG + Sbjct: 274 PVVAAIFVEPVRGGSGMKTVTPELAEELHRLRDTLGCPLVVDEVQTGIGRTGAFFGSALL 333 Query: 282 NVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLE 341 +R D L KA+ GG+ S L D L H ST+ + L +A+ LE++E Sbjct: 334 GIRGDYYTLAKAIGGGIVKNSVALIRQDRFLPAMEVIHSSTFAKDGLSASIALKVLEMVE 393 Query: 342 E------ENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCL 395 + + E +L +L + + SDVV+AV G GL+ A+ +++ + + + Sbjct: 394 ADGGRVYQRVRERGQRLEAMLES-VRADHSDVVSAVWGTGLMLALELRDQSNATSQAIRE 452 Query: 396 R--------------LRDNGLLAKPT--HGDIIRFAPPLVIKEDEL 425 + LR++ + P +RF+P L I ++E+ Sbjct: 453 KAAHGFLGYVLAGFLLREHHIRVLPAGPRSGFLRFSPSLYITDEEI 498 Score = 32.7 bits (73), Expect = 0.32, Method: Compositional matrix adjust. Identities = 26/99 (26%), Positives = 44/99 (44%), Gaps = 10/99 (10%) Query: 65 GKGIYLWDVEGRKY--FDFLSSYSAVNQGHCHPKIVNALKSQVD-------KLTLTSRAF 115 G +Y D EGR+ D + ++ GH HP+I+ K+ +D +L+ RA Sbjct: 33 GNTVYYLDDEGREVPVLDHACGFGSLIFGHNHPEIIAHAKAALDAGTVVHAQLSRQPRAN 92 Query: 116 Y-NNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLA 153 + +L + T + + + N+G EA E K A Sbjct: 93 QISRILNDIMRRETGRDDRYNAIFANSGAEANEICMKHA 131 >1OHW-A nrPDB Length = 472 Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 94/440 (21%), Positives = 171/440 (38%), Gaps = 81/440 (18%) Query: 63 ERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGE 122 E +G YL DV+G + D S S++ G+ HP +V ++ + T +R LG Sbjct: 50 EESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRP----ALGI 105 Query: 123 Y--EEYITKLFN---------YHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAK-- 169 E ++ KL +++ M G + E A K W + + Q +K Sbjct: 106 LPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEE 165 Query: 170 ----------------IVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLP 213 I+ G F GRT+ ++++ + +P FD P P Sbjct: 166 LETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHK---IDIPSFDW-PIAPFP 221 Query: 214 ALERALQD---------------------------PNVAAFMVEPIQGEAGVVVPDPGYL 246 L+ L++ VA +VEPIQ E G + Sbjct: 222 RLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFF 281 Query: 247 MGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVR--PDIVLLGKA-LSGGLYPVSA 303 +R++ +H F+ DE+QTG TG++ A ++ + D++ K ++GG + Sbjct: 282 RKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFF---- 337 Query: 304 VLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKL 363 + P +T+ G+P + + +++ E+L NA G +L L+ L Sbjct: 338 ---HKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDL 394 Query: 364 PS---DVVTAVRGKGLLNAIVIKETKDWDAWKVCLRL-RDNGLLAKPTHGDIIRFAPPLV 419 + ++ VRG+G + +T D + + R+ G++ IRF P LV Sbjct: 395 QARYPQFISRVRGRGTFCSF---DTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLV 451 Query: 420 IKEDELRESIEIINKTILSF 439 ++ + I + + F Sbjct: 452 FRDHHAHLFLNIFSDILADF 471 >2YKV-A nrPDB Length = 465 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 87/341 (25%), Positives = 132/341 (38%), Gaps = 38/341 (11%) Query: 31 KKTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQ 90 ++++ G T +F R P P+ + +G G DV+G Y +FL Y+A Sbjct: 65 RRSMPGGNTRSILFHR----------PFPLVIAQGTGSRFQDVDGHAYVNFLGEYTAGLF 114 Query: 91 GHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLF-NYHKVLPMNTGVEAGETA 149 GH HP I A++ + S N L + E + F + V N+G EA A Sbjct: 115 GHSHPVIRAAVERALAVGLNLSTQTENEAL--FAEAVCDRFPSIDLVRFTNSGTEANLMA 172 Query: 150 CKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPY 209 T I K + F G G L +S PT+ P+ + Y Sbjct: 173 LA-------TATAITGRKTVLAFDGGYHGG--LLNFASGHAPTN----APYHVVLGV--Y 217 Query: 210 NDLPALERALQ--DPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQT 267 ND+ L+ + AA +VEP+ G G V + +L +R +R L I DE+ T Sbjct: 218 NDVEGTADLLKRHGHDCAAILVEPMLGAGGCVPAERAFLDLLRAEASRCGALLIFDEVMT 277 Query: 268 GLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE-----HGST 322 +R A + + D+ LGK + GG+ A D+M P H T Sbjct: 278 --SRLSGGGAQEMLGISADLTTLGKYIGGGM-SFGAFGGRRDLMERFDPARDGAFAHAGT 334 Query: 323 YGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKL 363 + N L AAL + A + G R L ++ Sbjct: 335 FNNNILTMSAGHAALTQIYTRQAASDLSASGDRFRANLNRI 375 >4A0G-A nrPDB Length = 831 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 55/212 (25%), Positives = 94/212 (44%), Gaps = 20/212 (9%) Query: 220 QDPNVAAFMVEP-IQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAV 278 Q +V A ++EP I G G+ + DP + + C ++ I DE+ TG R G Sbjct: 591 QSAHVGALIIEPVIHGAGGMHMVDPLFQRVLVNECRNRKIPVIFDEVFTGFWRLGVETTT 650 Query: 279 DYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLT------IKPGEHGSTYGGNPLGCRV 332 + +PDI K L+GG+ P++ L D + + +K HG +Y + +GC Sbjct: 651 ELLGCKPDIACFAKLLTGGMVPLAVTLATDAVFDSFSGDSKLKALLHGHSYSAHAMGCAT 710 Query: 333 AIAALEVLEEENLAENADKLGIILR----NELMKLPS--DVVTAVRGKGLLNAIVIKETK 386 A A++ ++ N G LR EL++ S V V G L A+ +K Sbjct: 711 AAKAIQWFKDPETNHNITSQGKTLRELWDEELVQQISSHSAVQRVVVIGTLFALELKADA 770 Query: 387 DWDAW------KVCLRLRDNGLLAKPTHGDII 412 + + + LR++G+ +P G++I Sbjct: 771 SNSGYASLYAKSLLIMLREDGIFTRPL-GNVI 801 >2CY8-A nrPDB Length = 453 Score = 64.7 bits (156), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 78/326 (23%), Positives = 139/326 (42%), Gaps = 34/326 (10%) Query: 55 YHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRA 114 + P + + +G++ DV+G Y DF + A+ GH HP+ VNA ++ + A Sbjct: 36 FDPHGLFISDAQGVHKTDVDGNVYLDFFGGHGALVLGHGHPR-VNAAIAEALSHGVQYAA 94 Query: 115 FYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAA 174 + + E + + K+ +G E A ++AR + + I+ Sbjct: 95 SHPLEVRWAERIVAAFPSIRKLRFTGSGTETTLLALRVARAF--------TGRRMILRFE 146 Query: 175 GNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPY----------NDLPALERALQD--P 222 G++ G S+S + +DG P ++P +D+ + + Sbjct: 147 GHYHG--WHDFSASGYNSHFDG----QPAPGVLPETTANTLLIRPDDIEGMREVFANHGS 200 Query: 223 NVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYEN 282 ++AAF+ EP+ GV +L EL ++ LFI DE+ +G R G + Sbjct: 201 DIAAFIAEPVGSHFGVTPVSDSFLREGAELARQYGALFILDEVISGF-RVGNHGMQALLD 259 Query: 283 VRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE-----HGSTYGGNPLGCRVAIAAL 337 V+PD+ L KA S G P + +D+M + G H T+ GNP+ AIAA+ Sbjct: 260 VQPDLTCLAKA-SAGGLPGGILGGREDVMGVLSRGSDRKVLHQGTFTGNPITAAAAIAAI 318 Query: 338 EVLEEENLAENADKLGIILRNELMKL 363 + + E+++ + LG R + L Sbjct: 319 DTILEDDVCAKINDLGQFAREAMNHL 344 >6CBN-A nrPDB Length = 438 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 41/126 (32%), Positives = 61/126 (48%), Gaps = 11/126 (8%) Query: 182 LSAISSSTDPTSYDGFGPFMPGFDIIP--YNDLPALERALQDPN-VAAFMVEPIQGEAGV 238 LSA DP Y P P D + + DL L L+ P VAA +V P Sbjct: 147 LSAGYHGYDPMWYPSEAPLEPNADGVVDFFFDLGLLRELLRAPERVAAVVVSPDH----- 201 Query: 239 VVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGL 298 + PG+ +R LC+ V+ +ADE++ GL R L+ E + PD+ ++ K ++ G Sbjct: 202 MHLSPGWYRELRRLCSAAGVVLVADEVKVGL-RYAPGLST-AELLAPDVWVVAKGMANG- 258 Query: 299 YPVSAV 304 + VSAV Sbjct: 259 HAVSAV 264 >3L8A-A nrPDB Length = 421 Score = 37.0 bits (84), Expect = 0.019, Method: Compositional matrix adjust. Identities = 21/63 (33%), Positives = 32/63 (50%), Gaps = 1/63 (1%) Query: 211 DLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLA 270 D LE+ + D NV +++ G V D L+ + ELC +H V+ ++DEI LA Sbjct: 182 DFEQLEKDIIDNNVKIYLLCSPHNPGGRVW-DNDDLIKIAELCKKHGVILVSDEIHQDLA 240 Query: 271 RTG 273 G Sbjct: 241 LFG 243 >5Z8A-A nrPDB Length = 437 Score = 33.1 bits (74), Expect = 0.25, Method: Compositional matrix adjust. Identities = 60/267 (22%), Positives = 101/267 (37%), Gaps = 47/267 (17%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAF--- 115 P G G YL D +GR++ DF ++ +V GH ++ A+ + A+ Sbjct: 45 PRVFVEGSGAYLTDPDGRRWIDFDNARGSVVLGHGDEEVAEAIARAARGRSGVGTAWSPV 104 Query: 116 YNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAG 175 +++LG+ +E + V TG A + R IV ++G Sbjct: 105 LDSLLGQLQE----VCGGDVVGLYRTGTAALRSVTCAVR---------DARDRSIVLSSG 151 Query: 176 NFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGE 235 Y G+ P + N +E +A ++ P Q Sbjct: 152 ------------------YHGYDPMWHCDEPFTPNQHGIVEFLFDLDVLAEWLSRPEQVA 193 Query: 236 AGVVVPDPGYLMGVR------ELCTRHQVLFIADEIQTGLA-RTGRWLAVDYENVRPDIV 288 A V+ PD +L G R L V IADE++ GL R G + + P + Sbjct: 194 AVVISPDHMHL-GERWYTEFTRLTKEADVPVIADEVKVGLRYRAG----LSTPLLDPAVW 248 Query: 289 LLGKALSGGLYPVSAVLCDDDIMLTIK 315 ++ K L+ G PV+AV D ++ ++ Sbjct: 249 IVAKCLANG-SPVAAVGGDAHLLAALE 274 >6M9X-A nrPDB Length = 227 Score = 32.3 bits (72), Expect = 0.39, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 25/44 (56%), Gaps = 5/44 (11%) Query: 396 RLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF 439 ++R+N AKP DI++ P V ++ EL+ S KT L+F Sbjct: 168 KMRENNTFAKPMAADILQKQPMFVFRKSELQHS-----KTELTF 206 >3DZZ-A nrPDB Length = 391 Score = 32.0 bits (71), Expect = 0.55, Method: Compositional matrix adjust. Identities = 13/24 (54%), Positives = 16/24 (66%) Query: 249 VRELCTRHQVLFIADEIQTGLART 272 + ELC +HQVL I+DEI L T Sbjct: 185 IAELCAKHQVLLISDEIHGDLVLT 208 >2ZTC-A nrPDB Length = 212 Score = 31.6 bits (70), Expect = 0.77, Method: Compositional matrix adjust. Identities = 27/96 (28%), Positives = 40/96 (41%), Gaps = 19/96 (19%) Query: 193 SYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVREL 252 S G GP + + +D PAL + L D NVAA P G+ + Sbjct: 92 SVSGVGPRLA-MAALAVHDAPALRQVLADGNVAALTRVP----------------GIGKR 134 Query: 253 CTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIV 288 VL + D++ G+A TG L+ + VR +V Sbjct: 135 GAERMVLELRDKV--GVAATGGALSTNGHAVRSPVV 168 >5NRM-A nrPDB Length = 141 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 21/69 (30%), Positives = 34/69 (49%), Gaps = 1/69 (1%) Query: 226 AFMVEPIQGEAGVVVPDPGYLMGV-RELCTRHQVLFIADEIQTGLARTGRWLAVDYENVR 284 A +E I G+AG +V +PG G+ +E + +VLF+ + TG T A N++ Sbjct: 43 ATKLEYISGDAGSIVTNPGVNFGINKESDGKLKVLFLDYTMSTGYISTDGVFANLNFNIK 102 Query: 285 PDIVLLGKA 293 + KA Sbjct: 103 SSAAIGSKA 111 >1XRE-A nrPDB Length = 217 Score = 29.3 bits (64), Expect = 3.2, Method: Compositional matrix adjust. Identities = 25/68 (36%), Positives = 32/68 (47%), Gaps = 11/68 (16%) Query: 308 DDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDV 367 D L+I G+H +TY N AALE N +E +K L L LP ++ Sbjct: 30 DSNTLSIHHGKHHATYVNN------LNAALE-----NYSELHNKSLEELLCNLETLPKEI 78 Query: 368 VTAVRGKG 375 VTAVR G Sbjct: 79 VTAVRNNG 86 >5T51-A nrPDB Length = 120 Score = 29.3 bits (64), Expect = 3.7, Method: Composition-based stats. Identities = 13/42 (30%), Positives = 25/42 (59%) Query: 331 RVAIAALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVR 372 ++ A LE L E ++ +N DKL + + ++ +PSD++ R Sbjct: 62 KIGTAKLESLLENSVDKNFDKLELYVLRNILSIPSDLLEENR 103 >4QWV-A nrPDB Length = 321 Score = 28.1 bits (61), Expect = 7.2, Method: Compositional matrix adjust. Identities = 31/123 (25%), Positives = 55/123 (44%), Gaps = 30/123 (24%) Query: 186 SSSTDPTS--YDGFGPFMPGFDIIPYNDLPALER-------------ALQDPNVAAFMVE 230 SSST P S Y+ G M I P P L + + Q P A +++E Sbjct: 80 SSSTQPASDIYEDEGILM----ISPGATNPELTQRGYQHIMRTAGLDSSQGPTAAKYILE 135 Query: 231 PIQGEAGVVVPDPGYL-MGVRELCTR--HQVLFIADEIQTGLARTGRWLAVDYENVRPDI 287 ++ + ++V D ++ M ++++ T+ ++V G A GR Y+ ++PDI Sbjct: 136 TVKPQRVLIVDDAAFMRMMLKDIITKAGYEV--------AGEATNGREAVEKYKELKPDI 187 Query: 288 VLL 290 V + Sbjct: 188 VTM 190 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1OAT-A nrPDB 622 e-178 5VIU-A nrPDB 508 e-144 3NTJ-A nrPDB 496 e-140 1Z7D-A nrPDB 491 e-139 5EAV-A nrPDB 471 e-133 3RUY-A nrPDB 461 e-130 2EH6-A nrPDB 428 e-120 2E54-A nrPDB 427 e-120 4JF0-A nrPDB 411 e-115 5KR6-A nrPDB 407 e-114 5KQW-A nrPDB 403 e-113 1WKH-A nrPDB 403 e-113 3N5M-A nrPDB 403 e-112 4ADC-A nrPDB 402 e-112 6IO1-A nrPDB 402 e-112 5KR3-A nrPDB 398 e-111 5KR5-A nrPDB 394 e-110 3NX3-A nrPDB 392 e-109 6GWI-A nrPDB 389 e-108 5TI8-A nrPDB 388 e-108 6FYQ-A nrPDB 387 e-108 6G4F-A nrPDB 385 e-107 5KQU-A nrPDB 383 e-107 5GHG-A nrPDB 380 e-106 4BQ0-A nrPDB 373 e-104 5X3F-A nrPDB 371 e-103 4UHN-A nrPDB 370 e-103 4BA4-A nrPDB 368 e-102 5LL2-A nrPDB 368 e-102 5LH9-A nrPDB 367 e-102 3GJU-A nrPDB 366 e-101 3DOD-A nrPDB 364 e-101 2EO5-A nrPDB 362 e-100 5KQT-A nrPDB 360 e-100 3HMU-A nrPDB 359 2e-99 3FCR-A nrPDB 358 3e-99 3R4T-A nrPDB 357 5e-99 3OKS-A nrPDB 356 8e-99 1SFF-A nrPDB 356 9e-99 4E3Q-A nrPDB 351 4e-97 6ERK-A nrPDB 350 1e-96 4GRX-A nrPDB 350 1e-96 5UC7-A nrPDB 340 6e-94 3A8U-X nrPDB 340 9e-94 4PPM-A nrPDB 334 6e-92 3I5T-A nrPDB 333 1e-91 3Q8N-A nrPDB 330 6e-91 1S09-A nrPDB 326 1e-89 5M46-A nrPDB 312 2e-85 1ZOD-A nrPDB 312 3e-85 4FFC-A nrPDB 310 7e-85 5G4J-A nrPDB 310 1e-84 5G0A-A nrPDB 308 2e-84 4ATP-A nrPDB 306 1e-83 2CFB-A nrPDB 303 1e-82 4WYG-A nrPDB 301 4e-82 6GIO-D nrPDB 301 5e-82 4GSA-A nrPDB 293 8e-80 4E77-A nrPDB 293 1e-79 5HDM-A nrPDB 290 7e-79 3L44-A nrPDB 289 1e-78 2JJG-A nrPDB 289 1e-78 2ZUK-A nrPDB 287 5e-78 3I4J-A nrPDB 286 1e-77 4AOA-A nrPDB 286 2e-77 1OHW-A nrPDB 285 3e-77 3K28-A nrPDB 285 3e-77 5I92-A nrPDB 282 1e-76 3BS8-A nrPDB 280 8e-76 2E7U-A nrPDB 273 9e-74 2EPJ-A nrPDB 253 8e-68 2YKV-A nrPDB 242 2e-64 4ZM4-A nrPDB 235 2e-62 2CY8-A nrPDB 217 6e-57 5YKR-A nrPDB 216 2e-56 5DDW-A nrPDB 214 8e-56 4A0G-A nrPDB 194 9e-50 6CBN-A nrPDB 117 7e-27 Sequences not found previously or not previously below threshold: 5Z8A-A nrPDB 111 6e-25 2BWN-A nrPDB 60 3e-09 6HRH-B nrPDB 58 6e-09 1FC4-A nrPDB 56 3e-08 1V2E-A nrPDB 55 7e-08 3TQX-A nrPDB 54 2e-07 1GC4-A nrPDB 53 2e-07 2DR1-A nrPDB 51 7e-07 3A2B-A nrPDB 51 8e-07 5JAY-A nrPDB 50 2e-06 6ONN-A nrPDB 50 3e-06 4ISY-A nrPDB 49 4e-06 5TXT-B nrPDB 49 4e-06 3WY7-A nrPDB 46 2e-05 3BB8-A nrPDB 46 3e-05 2CH1-A nrPDB 45 7e-05 2X8U-A nrPDB 41 8e-04 5HH9-A nrPDB 41 9e-04 5YHV-A nrPDB 40 0.002 2YRI-A nrPDB 40 0.002 3UWC-A nrPDB 40 0.002 3LWS-A nrPDB 40 0.002 3WGB-A nrPDB 40 0.003 1O4S-A nrPDB 39 0.004 1VJO-A nrPDB 38 0.007 2OGE-A nrPDB 37 0.018 3PJ0-A nrPDB 36 0.022 5XT5-A nrPDB 36 0.026 4OBV-D nrPDB 36 0.026 5Z0Y-A nrPDB 36 0.041 4WP0-A nrPDB 35 0.051 3FVS-A nrPDB 35 0.051 3L8A-A nrPDB 35 0.099 4GDY-A nrPDB 35 0.10 3NYS-A nrPDB 34 0.11 5VC2-A nrPDB 34 0.14 2YIU-B nrPDB 34 0.15 4BMK-A nrPDB 33 0.19 5WGB-A nrPDB 33 0.20 4HGV-A nrPDB 33 0.22 3KE3-A nrPDB 33 0.25 1I43-A nrPDB 33 0.29 1M32-A nrPDB 33 0.37 2C44-A nrPDB 33 0.38 3DZZ-A nrPDB 32 0.49 2GB3-A nrPDB 32 0.54 3O59-X nrPDB 32 0.60 3I4K-A nrPDB 32 0.66 2X5D-A nrPDB 32 0.67 3B1C-A nrPDB 31 0.68 2GMS-A nrPDB 31 0.71 4Q75-A nrPDB 31 0.72 1F1U-A nrPDB 31 0.86 3B46-A nrPDB 31 0.91 4GHC-A nrPDB 31 0.96 1E19-A nrPDB 31 0.96 3IF2-A nrPDB 31 0.98 4CVQ-A nrPDB 31 1.0 3MAF-B nrPDB 31 1.1 1O69-A nrPDB 31 1.1 5W1B-A nrPDB 31 1.3 5JD3-A nrPDB 31 1.3 4Q6R-A nrPDB 30 1.6 1YIY-A nrPDB 30 1.6 5WT2-A nrPDB 30 1.6 2HUU-A nrPDB 30 1.6 4H6W-A nrPDB 30 1.8 5K8B-A nrPDB 30 1.9 4EXQ-A nrPDB 30 2.1 3RI6-A nrPDB 30 2.2 4CO7-A nrPDB 30 2.2 1YFM-A nrPDB 30 2.3 3KGX-A nrPDB 30 2.6 3VK2-A nrPDB 30 2.9 1GDE-A nrPDB 30 3.3 5VKU-h nrPDB 30 3.3 1WZC-A nrPDB 29 3.4 3V4G-A nrPDB 29 3.5 6ACF-A nrPDB 29 3.6 3ZXX-A nrPDB 29 3.7 4W8Y-A nrPDB 29 3.7 2ZJG-A nrPDB 29 3.9 2BS2-A nrPDB 29 4.1 3J9R-A nrPDB 29 4.5 2EZ1-A nrPDB 29 4.7 1NU5-A nrPDB 29 4.8 6J36-A nrPDB 29 5.4 3ISL-A nrPDB 29 5.6 3WYD-A nrPDB 28 7.3 3NNK-A nrPDB 28 8.2 1KNR-A nrPDB 28 8.8 3NL2-A nrPDB 28 9.1 >1OAT-A nrPDB Length = 439 Score = 622 bits (1604), Expect = e-178, Method: Composition-based stats. Identities = 439/439 (100%), Positives = 439/439 (100%) Query: 1 MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPV 60 MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPV Sbjct: 1 MFSKLAHLQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPV 60 Query: 61 ALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVL 120 ALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVL Sbjct: 61 ALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVL 120 Query: 121 GEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGR 180 GEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGR Sbjct: 121 GEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGR 180 Query: 181 TLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVV 240 TLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVV Sbjct: 181 TLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVV 240 Query: 241 PDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYP 300 PDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYP Sbjct: 241 PDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYP 300 Query: 301 VSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNEL 360 VSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNEL Sbjct: 301 VSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNEL 360 Query: 361 MKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVI 420 MKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVI Sbjct: 361 MKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVI 420 Query: 421 KEDELRESIEIINKTILSF 439 KEDELRESIEIINKTILSF Sbjct: 421 KEDELRESIEIINKTILSF 439 >5VIU-A nrPDB Length = 419 Score = 508 bits (1309), Expect = e-144, Method: Composition-based stats. Identities = 251/407 (61%), Positives = 316/407 (77%), Gaps = 5/407 (1%) Query: 38 PTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKI 97 S+ E E K+GAHNYHPLPV L+RG+G+++WDVEG+KY+DFLS+YSAVNQGH HPKI Sbjct: 13 KNSEYFIELEEKHGAHNYHPLPVVLDRGEGVFVWDVEGKKYYDFLSAYSAVNQGHSHPKI 72 Query: 98 VNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWG 157 V AL Q KL LTSRAFYN+ LGEYE+ IT L + KVLPMN+G EA ETA KLARKW Sbjct: 73 VEALVEQASKLALTSRAFYNSKLGEYEQKITSLLGFDKVLPMNSGAEAVETAVKLARKWS 132 Query: 158 YTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALER 217 Y VKGI + AKI+ NF GRT + +S S DP + +GPF PGF IPYND+ ALE Sbjct: 133 YEVKGIAENAAKIIVCENNFHGRTTTIVSFSNDPDANQNYGPFTPGFIRIPYNDIAALEE 192 Query: 218 AL--QDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRW 275 L + N+AAF+VEPIQGEAGV VP+ G+L ELC +H VLFIADE+QTG+ARTG+ Sbjct: 193 VLSKEAGNIAAFLVEPIQGEAGVYVPNEGFLKQSSELCKKHNVLFIADEVQTGIARTGKL 252 Query: 276 LAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIA 335 +A +E+V+PDI++LGKALSGG+YPVSAVL +++IM IKPG+HGST+GGNPL C VA+A Sbjct: 253 IACHHEDVQPDILILGKALSGGMYPVSAVLANNNIMDVIKPGQHGSTFGGNPLACAVAMA 312 Query: 336 ALEVLEEENLAENADKLGIILRNELMKLPS--DVVTAVRGKGLLNAIVIKETKDWD-AWK 392 AL+V+++E L+E A+KLG + R+E+ KL D++T VRGKGLLNAI+I +T D AW Sbjct: 313 ALDVVQDEKLSERAEKLGNLFRSEIEKLIEKTDLITKVRGKGLLNAILINDTPDSSTAWN 372 Query: 393 VCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF 439 +CL L++NGLLAKPTHG+IIR APPLVI E++L + ++II KTIL F Sbjct: 373 LCLALKENGLLAKPTHGNIIRLAPPLVITEEQLLDCVKIIEKTILEF 419 >3NTJ-A nrPDB Length = 422 Score = 496 bits (1276), Expect = e-140, Method: Composition-based stats. Identities = 223/409 (54%), Positives = 286/409 (69%), Gaps = 3/409 (0%) Query: 33 TVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGH 92 V+ +S D E YGAHNY P+PV L+RGKG++++D+E R+Y+DFLS+YS+VNQGH Sbjct: 3 FVKELKSSQDYMNNELTYGAHNYDPIPVVLKRGKGVFVYDIEDRRYYDFLSAYSSVNQGH 62 Query: 93 CHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKL 152 CHP I+NA+ +Q KLT+ SRAF+++ LG E Y+T LF Y KVL MNTG EA ETA KL Sbjct: 63 CHPDILNAMINQAKKLTICSRAFFSDSLGVCERYLTNLFGYDKVLMMNTGAEASETAYKL 122 Query: 153 ARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDL 212 RKWGY VK I + AKI+ NF GRTL +S+STD + FGPF+P F +PY+DL Sbjct: 123 CRKWGYEVKKIPENSAKIIVCNNNFSGRTLGCVSASTDKKCKNNFGPFVPNFLKVPYDDL 182 Query: 213 PALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLART 272 ALE+ LQDPNV AF+VEP+QGEAGV+VP Y GV LC ++ VLF+ADE+QTGL RT Sbjct: 183 EALEKELQDPNVCAFIVEPVQGEAGVIVPSDSYFPGVASLCKKYNVLFVADEVQTGLGRT 242 Query: 273 GRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRV 332 G+ L + V+PD++LLGKALSGG YP+SA+L +DD+ML +KPGEHGSTYGGNPL + Sbjct: 243 GKLLCTHHYGVKPDVILLGKALSGGHYPISAILANDDVMLVLKPGEHGSTYGGNPLAAAI 302 Query: 333 AIAALEVLEEENLAENADKLGIILRNELMKL--PSDVVTAVRGKGLLNAIVIKETKDWDA 390 + AL+VL E L ENADKLG L + S VV VRGKGLL AI K + Sbjct: 303 CVEALKVLINEKLCENADKLGAPFLQNLKEQLKDSKVVREVRGKGLLCAIEFKNDL-VNV 361 Query: 391 WKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF 439 W +CL+ ++NGL+ + H +R PPL I +++L E EII KT+ F Sbjct: 362 WDICLKFKENGLITRSVHDKTVRLTPPLCITKEQLDECTEIIVKTVKFF 410 >1Z7D-A nrPDB Length = 433 Score = 491 bits (1265), Expect = e-139, Method: Composition-based stats. Identities = 225/410 (54%), Positives = 283/410 (69%), Gaps = 3/410 (0%) Query: 32 KTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQG 91 + V+ T +D E KYGAHNY P+PV L+R KG++++DV ++Y+DFLS+YS+VNQG Sbjct: 21 EFVKDLKTPEDYINNELKYGAHNYDPIPVVLKRAKGVFVYDVNDKRYYDFLSAYSSVNQG 80 Query: 92 HCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACK 151 HCHP I+NA+ +Q LT+ SRAF++ LG E Y+T L Y KVL MNTG EA ETA K Sbjct: 81 HCHPNILNAMINQAKNLTICSRAFFSVPLGICERYLTNLLGYDKVLMMNTGAEANETAYK 140 Query: 152 LARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYND 211 L RKWGY VK I + AKIV NF GRTL IS+ST FGPF P F +PY+D Sbjct: 141 LCRKWGYEVKKIPENMAKIVVCKNNFSGRTLGCISASTTKKCTSNFGPFAPQFSKVPYDD 200 Query: 212 LPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLAR 271 L ALE L+DPNV AF+VEPIQGEAGV+VP YL GV ++C ++ VLF+ADE+QTGL R Sbjct: 201 LEALEEELKDPNVCAFIVEPIQGEAGVIVPSDNYLQGVYDICKKYNVLFVADEVQTGLGR 260 Query: 272 TGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCR 331 TG+ L V + NV+PD++LLGKALSGG YP+SAVL +DDIML IKPGEHGSTYGGNPL Sbjct: 261 TGKLLCVHHYNVKPDVILLGKALSGGHYPISAVLANDDIMLVIKPGEHGSTYGGNPLAAS 320 Query: 332 VAIAALEVLEEENLAENADKLGIILRNELMKL--PSDVVTAVRGKGLLNAIVIKETKDWD 389 + + AL VL E L ENA+KLG L + S +V VRGKGLL AI K + + Sbjct: 321 ICVEALNVLINEKLCENAEKLGGPFLENLKRELKDSKIVRDVRGKGLLCAIEFK-NELVN 379 Query: 390 AWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF 439 +CL+L++NGL+ + H IR PPL I +++L E EII KT+ F Sbjct: 380 VLDICLKLKENGLITRDVHDKTIRLTPPLCITKEQLDECTEIIVKTVKFF 429 >5EAV-A nrPDB Length = 441 Score = 471 bits (1213), Expect = e-133, Method: Composition-based stats. Identities = 206/416 (49%), Positives = 283/416 (68%), Gaps = 4/416 (0%) Query: 26 TSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSY 85 T++ + T +D F + +Y NY P+PV + +GKG +WD+ G +Y+DFL+ Sbjct: 20 TNIEAYRDGLKLKTEEDFFACDRQYVCQNYAPVPVVISKGKGARVWDINGNEYYDFLAGV 79 Query: 86 SAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEA 145 S+++QGHCHP+++ AL Q ++LTLT RAF N+V G ++ ++F Y +VL MNTG EA Sbjct: 80 SSLSQGHCHPRVIAALCRQAERLTLTLRAFGNDVTGPACRFMAEMFGYDRVLLMNTGAEA 139 Query: 146 GETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFD 205 GE+A K+ARKW Y VK I AK++ N+WGRT++A SSST Y+ FGPF PGF+ Sbjct: 140 GESALKIARKWAYEVKEIPPDSAKVILCNNNYWGRTITACSSSTTFDCYNNFGPFTPGFE 199 Query: 206 IIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEI 265 +I Y+D+ ALE AL+DPNVAAF VEPIQGE GV VP PGYL ELC VL I DEI Sbjct: 200 LIDYDDVGALEEALKDPNVAAFFVEPIQGEGGVNVPKPGYLKRAHELCRSKNVLLIVDEI 259 Query: 266 QTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGG 325 QTGL RTGR LA D++ V PDI+LLGK+LS G+ P+SAV+ D+M +KPG HGST+GG Sbjct: 260 QTGLCRTGRLLAADHDEVHPDILLLGKSLSAGVVPISAVMGRADVMDVLKPGTHGSTFGG 319 Query: 326 NPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDVV---TAVRGKGLLNAIVI 382 NPL C VA+ AL VL++E LA+ A++LG R+ L + V +RG+GLLNA+ + Sbjct: 320 NPLACAVAVEALTVLKDEKLADRAERLGAQFRDCLRRELYGKVPWIKEIRGRGLLNAVEV 379 Query: 383 KETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILS 438 D V ++L++NG+L+KPT G ++RF PPLVI ++E R++ I K+ L+ Sbjct: 380 DSDA-IDPNDVVMKLKENGILSKPTRGRVMRFIPPLVITDEEHRDATTRIIKSFLA 434 >3RUY-A nrPDB Length = 392 Score = 461 bits (1186), Expect = e-130, Method: Composition-based stats. Identities = 199/396 (50%), Positives = 271/396 (68%), Gaps = 5/396 (1%) Query: 42 DIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNAL 101 DI E YGA+NYHPLP+ + + +G+++ D EG +Y D LS+YSAVNQGH HPKI+NAL Sbjct: 2 DIIELTDTYGANNYHPLPIVISKAEGVWVEDPEGNRYMDLLSAYSAVNQGHRHPKIINAL 61 Query: 102 KSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVK 161 Q +++TLTSRAF+++ LG + E + KL N VLPMNTG EA ETA K AR+W Y VK Sbjct: 62 IDQANRVTLTSRAFHSDQLGPWYEKVAKLTNKEMVLPMNTGAEAVETAIKTARRWAYDVK 121 Query: 162 GIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQD 221 ++ +A+I+ NF GRT+ A+S S++ GFGP +PG +IPY DL AL+ A+ Sbjct: 122 KVEANRAEIIVCEDNFHGRTMGAVSMSSNEEYKRGFGPMLPGIIVIPYGDLEALKAAIT- 180 Query: 222 PNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYE 281 PN AAF++EPIQGEAG+ +P G+L E+C + VLF+ADEIQTGL RTG+ A D++ Sbjct: 181 PNTAAFILEPIQGEAGINIPPAGFLKEALEVCKKENVLFVADEIQTGLGRTGKVFACDWD 240 Query: 282 NVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLE 341 NV PD+ +LGKAL GG++P+S + DI+ +PG HGST+GGNPL C V+IAALEVLE Sbjct: 241 NVTPDMYILGKALGGGVFPISCAAANRDILGVFEPGSHGSTFGGNPLACAVSIAALEVLE 300 Query: 342 EENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNG 401 EE L E + +LG L +L ++ + ++T VRGKGL I + E A C +L+ G Sbjct: 301 EEKLTERSLQLGEKLVGQLKEIDNPMITEVRGKGLFIGIELNEP----ARPYCEQLKAAG 356 Query: 402 LLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTIL 437 LL K TH ++IR APPLVI E++L + + I + Sbjct: 357 LLCKETHENVIRIAPPLVISEEDLEWAFQKIKAVLS 392 >2EH6-A nrPDB Length = 375 Score = 428 bits (1101), Expect = e-120, Method: Composition-based stats. Identities = 138/389 (35%), Positives = 216/389 (55%), Gaps = 15/389 (3%) Query: 49 KYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKL 108 Y +NY LPV RGKG+YL+D EG++Y DF+S + GH +PK+ ALK QV+KL Sbjct: 1 TYLMNNYARLPVKFVRGKGVYLYDEEGKEYLDFVSGIGVNSLGHAYPKLTEALKEQVEKL 60 Query: 109 TLTSRAFYNNVLGEYEEYITKLF-NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYK 167 S + N E + K F KV N+G E+ E A KLARK+ + KG K K Sbjct: 61 LHVSNLYENPWQEELAHKLVKHFWTEGKVFFANSGTESVEAAIKLARKY-WRDKG--KNK 117 Query: 168 AKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAF 227 K + +F GRT ++S++ P + GF P +PGF ND+ ++ + L D A Sbjct: 118 WKFISFENSFHGRTYGSLSATGQPKFHKGFEPLVPGFSYAKLNDIDSVYKLL-DEETAGI 176 Query: 228 MVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDI 287 ++E IQGE GV +L ++E+C VL I DE+QTG+ RTG + A + N++PD+ Sbjct: 177 IIEVIQGEGGVNEASEDFLSKLQEICKEKDVLLIIDEVQTGIGRTGEFYAYQHFNLKPDV 236 Query: 288 VLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAE 347 + L K L GG P+ A+L +++ + PG HGST+GGNPL CR ++ E E L Sbjct: 237 IALAKGLGGG-VPIGAILAREEVAQSFTPGSHGSTFGGNPLACRAGTVVVD--EVEKLLP 293 Query: 348 NADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPT 407 + ++G + +L +L V+G+GL+ + + + + L+ + GLL T Sbjct: 294 HVREVGNYFKEKLKELGK---GKVKGRGLMLGLEL----ERECKDYVLKALEKGLLINCT 346 Query: 408 HGDIIRFAPPLVIKEDELRESIEIINKTI 436 G ++RF PPL+I+++ + +I ++ + + Sbjct: 347 AGKVLRFLPPLIIQKEHIDRAISVLREIL 375 >2E54-A nrPDB Length = 385 Score = 427 bits (1099), Expect = e-120, Method: Composition-based stats. Identities = 134/389 (34%), Positives = 208/389 (53%), Gaps = 10/389 (2%) Query: 50 YGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLT 109 Y + Y P GKG +++D +G Y DF S + GH HP++V A+K Q +KL Sbjct: 2 YLMNTYSRFPATFVYGKGSWIYDEKGNAYLDFTSGIAVNVLGHSHPRLVEAIKDQAEKLI 61 Query: 110 LTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAK 169 S F+N E E ++K KV NTG EA E A K+ARK K + K + Sbjct: 62 HCSNLFWNRPQMELAELLSKNTFGGKVFFANTGTEANEAAIKIARK---YGKKKSEKKYR 118 Query: 170 IVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMV 229 I+ A +F GRTL +++++ P F P +PGF+ +N++ L R + +V A + Sbjct: 119 ILSAHNSFHGRTLGSLTATGQPKYQKPFEPLVPGFEYFEFNNVEDLRRKM-SEDVCAVFL 177 Query: 230 EPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVL 289 EPIQGE+G+V +L R+LC + L + DE+Q G+ RTG+ A V PD++ Sbjct: 178 EPIQGESGIVPATKEFLEEARKLCDEYDALLVFDEVQCGMGRTGKLFAYQKYGVVPDVLT 237 Query: 290 LGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENA 349 K L GG P+ AV+ + + ++PG+HG+T+GGNPL CR + ++ L +E E Sbjct: 238 TAKGLGGG-VPIGAVIVN-ERANVLEPGDHGTTFGGNPLACRAGVTVIKELTKEGFLEEV 295 Query: 350 DKLGIILRNELMKLPS--DVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPT 407 ++ G L +L ++ DVV VRG GL+ I +E + +V + +N LL P Sbjct: 296 EEKGNYLMKKLQEMKEEYDVVADVRGMGLMIGIQFRE--EVSNREVATKCFENKLLVVPA 353 Query: 408 HGDIIRFAPPLVIKEDELRESIEIINKTI 436 + IRF PPL ++ E+ ++E + K + Sbjct: 354 GNNTIRFLPPLTVEYGEIDLAVETLKKVL 382 >4JF0-A nrPDB Length = 422 Score = 411 bits (1057), Expect = e-115, Method: Composition-based stats. Identities = 145/414 (35%), Positives = 208/414 (50%), Gaps = 13/414 (3%) Query: 25 ATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSS 84 A+ +AT++T T D++ Y P +GKG +WD +G++Y DF Sbjct: 13 ASHMATEQTAITRATFDEVILP-------VYAPADFIPVKGKGSRVWDQQGKEYIDFAGG 65 Query: 85 YSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVE 144 + GHCHP +V ALKSQ + L TSR F N + +VL MN+G E Sbjct: 66 IAVTALGHCHPALVEALKSQGETLWHTSRVFTNEPALRLGRKLIDATFAERVLFMNSGTE 125 Query: 145 AGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGF 204 A ETA KLAR + +K KI+ F GR+L +S P DGFGP Sbjct: 126 ANETAFKLARHYA--CVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADI 183 Query: 205 DIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADE 264 +P+NDL A+ +A+ D + A +VEPIQGE GV P +L G+R+LC HQ L + DE Sbjct: 184 IHVPFNDLHAV-KAVMDDHTCAVVVEPIQGEGGVQAATPEFLKGLRDLCDEHQALLVFDE 242 Query: 265 IQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYG 324 +Q G+ RTG A + V PDI+ KAL GG +PVSA+L +I G HGSTYG Sbjct: 243 VQCGMGRTGDLFAYMHYGVTPDILTSAKALGGG-FPVSAMLTTQEIASAFHVGSHGSTYG 301 Query: 325 GNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPS--DVVTAVRGKGLLNAIVI 382 GNPL C VA A +++ + + L + D+ + +RG GLL + Sbjct: 302 GNPLACAVAGATFDIINTPEVLQGIHTKRQQFVQHLQAIDEQFDIFSDIRGMGLLIGAEL 361 Query: 383 KETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTI 436 K A + G++ D++RFAP LV++E ++ E ++ + + Sbjct: 362 KPKYKGRARDFLYAGAEAGVMVLNAGADVMRFAPSLVVEEADIHEGMQRFAQAV 415 >5KR6-A nrPDB Length = 479 Score = 407 bits (1045), Expect = e-114, Method: Composition-based stats. Identities = 125/458 (27%), Positives = 201/458 (43%), Gaps = 71/458 (15%) Query: 40 SDDIFEREYKYGAHNYHP-----------LP-VALERGKGIYLWDVEGRKYFDFLSSYSA 87 +DD+ E + AH +HP LP + GKGI + D EGR+Y D + Sbjct: 24 TDDLLEMDR---AHFFHPSTHLRDHASGELPGRIITGGKGIRIQDSEGREYIDAFAGLYC 80 Query: 88 VNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKL----------FNYHKVL 137 VN G+ +I +A+ Q +L A+Y+ +G E I +L KV Sbjct: 81 VNVGYGRTEIADAIYEQAKEL-----AYYHTYVGHSNEPIIELSERIIREWAPAGMSKVY 135 Query: 138 PMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGF 197 +G +A ET KL W Y + K KI+ + G + S + P ++ F Sbjct: 136 YGMSGSDANETQIKLV--WYYNNVLGRPQKKKIISRQRGYHGSGIMTGSLTGLPAFHNHF 193 Query: 198 G-PFMP-------------------GFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAG 237 P P F ++L + A VAAF+ EP+ G G Sbjct: 194 DLPLEPIRHTTCPHYYRAPAGMSEAEFSRHCADELEKMILAEGPDTVAAFIGEPVMGTGG 253 Query: 238 VVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGG 297 +V P GY ++ + ++ +L IADE+ G RTG + ++PD++ + K L+ Sbjct: 254 IVPPPEGYWEAIQAVLNKYDILLIADEVVCGFGRTGSMFGSHHYGMKPDLITVAKGLTSA 313 Query: 298 LYPVSAVLCDDDIMLTIKPG-------EHGSTYGGNPLGCRVAIAALEVLEEENLAENAD 350 P+S V+ + + ++ G HG TY G+P+ A+A L+++E ENL NA Sbjct: 314 YAPLSGVIVGEKVWKVLEQGSDQYGPIGHGWTYSGHPICAAAALANLDIIERENLTGNAA 373 Query: 351 KLGIILRNELMKL--PSDVVTAVRGKGLLNAIVIKETKDWD---------AWKVCLRLRD 399 G + + + +V VRG GL+ A+ KD +V + Sbjct: 374 DTGAYFQQRMRETFGDHPLVGEVRGVGLMAALEFVADKDKRTRFDPSLKVGPRVSAACLE 433 Query: 400 NGLLAKPT-HGDIIRFAPPLVIKEDELRESIEIINKTI 436 +G++A+ HGDI+ FAPPLVI E+ E ++I + + Sbjct: 434 DGMIARAMPHGDILGFAPPLVITRAEVDEIVDIAKQAV 471 >5KQW-A nrPDB Length = 479 Score = 403 bits (1037), Expect = e-113, Method: Composition-based stats. Identities = 126/459 (27%), Positives = 200/459 (43%), Gaps = 71/459 (15%) Query: 41 DDIFEREYKYGAHNYHP-----------LP-VALERGKGIYLWDVEGRKYFDFLSSYSAV 88 D +FE + AH HP LP + GKGI + D EGR+Y D + V Sbjct: 25 DQLFEMDR---AHFMHPSTHAHDHASGALPGRIITGGKGIRIQDHEGREYIDAFAGLYCV 81 Query: 89 NQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKL----------FNYHKVLP 138 N G+ ++ +A+ Q +L A+Y+ +G E I +L KV Sbjct: 82 NIGYGRTEVADAIYEQAKEL-----AYYHTYVGHSTEAIIELSSRIIRDWAPAGMKKVYY 136 Query: 139 MNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFG 198 +G +A ET KL W Y + K KI+ + G + S + P+ + F Sbjct: 137 GMSGSDANETQIKLV--WYYNNVLGRPQKKKIISRQRGYHGSGIMTGSLTGLPSFHQHFD 194 Query: 199 PFMPGFDI--IPY------------------NDLPALERALQDPNVAAFMVEPIQGEAGV 238 + P+ ++L L A VAAF+ EP+ G G+ Sbjct: 195 LPIERIKHTVCPHWYKAPAGMSEAQFVRYCADELEKLILAEGPDTVAAFIGEPVMGTGGI 254 Query: 239 VVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGL 298 + P GY ++ + ++ +L IADE+ G R G + + ++PD++ + K L+ Sbjct: 255 IPPPQGYWEAIQAVLNKYDILLIADEVVCGFGRLGSKMGSQHYGMKPDLITVAKGLTSAY 314 Query: 299 YPVSAVLCDDDIMLTIKPG-------EHGSTYGGNPLGCRVAIAALEVLEEENLAENADK 351 P+S V+ + + I+ G HG TY G+P+ A+A L++LE ENL NA Sbjct: 315 APLSGVIVGEKVWDVIEKGSQEHGPMGHGWTYSGHPICAAAALANLDILERENLTGNAAD 374 Query: 352 LGIILRNELMKL--PSDVVTAVRGKGLLNAIVIKETKDWD---------AWKVCLRLRDN 400 +G L+ L + +V VRG G+L A+ KD KV ++ Sbjct: 375 VGAYLQQRLRETFGGHPLVGEVRGVGMLAALEFMADKDARTPFDPALKVGPKVSAACLED 434 Query: 401 GLLAKPT-HGDIIRFAPPLVIKEDELRESIEIINKTILS 438 G++A+ HGDI+ FAPPLVI E+ E + I + + Sbjct: 435 GMIARAMPHGDILGFAPPLVITRAEVDEIVGIAKQAVDE 473 >1WKH-A nrPDB Length = 395 Score = 403 bits (1035), Expect = e-113, Method: Composition-based stats. Identities = 135/397 (34%), Positives = 209/397 (52%), Gaps = 15/397 (3%) Query: 43 IFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALK 102 + E E + Y+ + + RG+G +WD EG +Y D + Y N GH +P++V A+K Sbjct: 12 LLEAEKTLDSGVYNKHDLLIVRGQGARVWDAEGNEYIDCVGGYGVANLGHGNPEVVEAVK 71 Query: 103 SQVDKLTLTSRAFYNNVLGEYEEYITKL--FNYHKVLPMNTGVEAGETACKLARKWGYTV 160 Q + L + + GE+ +T + ++V P+N+G EA E A K AR Sbjct: 72 RQAETLMAMPQTLPTPMRGEFYRTLTAILPPELNRVFPVNSGTEANEAALKFARA----- 126 Query: 161 KGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQ 220 + K V A F GRT+ ++S + +P + F P + + IPYND+ AL+RA+ Sbjct: 127 ---HTGRKKFVAAMRGFSGRTMGSLSVTWEPKYREPFLPLVEPVEFIPYNDVEALKRAV- 182 Query: 221 DPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDY 280 D AA ++EP+QGE GV P +L RE+ L I DEIQTG+ RTG+ A ++ Sbjct: 183 DEETAAVILEPVQGEGGVRPATPEFLRAAREITQEKGALLILDEIQTGMGRTGKRFAFEH 242 Query: 281 ENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVL 340 + PDI+ L KAL GG P+ + +++ ++ G HG+T+GGNPL +AA+ L Sbjct: 243 FGIVPDILTLAKALGGG-VPLGVAVMREEVARSMPKGGHGTTFGGNPLAMAAGVAAIRYL 301 Query: 341 EEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDN 400 E L E A +LG +L +PS + VRG GL+ + +KE ++ R Sbjct: 302 ERTRLWERAAELGPWFMEKLRAIPSPKIREVRGMGLMVGLELKEKAAPYIARLEKEHRVL 361 Query: 401 GLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTIL 437 L A PT +IRF PPLVI++++L +E + + Sbjct: 362 ALQAGPT---VIRFLPPLVIEKEDLERVVEAVRAVLA 395 >3N5M-A nrPDB Length = 452 Score = 403 bits (1035), Expect = e-112, Method: Composition-based stats. Identities = 108/444 (24%), Positives = 198/444 (44%), Gaps = 48/444 (10%) Query: 40 SDDIFEREYKYGAHNYHPLP----VALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHP 95 +D++ ++ +Y H P + +G ++ D++G++Y D +S VN G+ Sbjct: 9 TDELLAKDEQYVWHGMRPFSPNSTTVGAKAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRK 68 Query: 96 KIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKV-LPMNTGVEAGETACKLAR 154 ++ A Q+ L+ + + + E + + V N+G EA ETA K+AR Sbjct: 69 ELAEAAYKQLQTLSYFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIAR 128 Query: 155 KWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYND--- 211 ++ + + ++ K + + G T++ ++++ + PF GF + D Sbjct: 129 QYY--AQKGEPHRYKFMSRYRGYHGNTMATMAATGQAQRRYQYEPFASGFLHVTPPDCYR 186 Query: 212 LPALERA-----------------LQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCT 254 +P +ER +AAF++EPI G+++ Y+ V E C Sbjct: 187 MPGIERENIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMAPQDYMKAVHETCQ 246 Query: 255 RHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTI 314 +H L I+DE+ G RTG+ +V+PDI+ + K ++ P+SA +I Sbjct: 247 KHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKREIYEAF 306 Query: 315 KP------GEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLP--SD 366 K H +T+GGNP C +A+ LE++E ENL E + ++G +L +L + Sbjct: 307 KGKGEYEFFRHINTFGGNPAACALALKNLEIIENENLIERSAQMGSLLLEQLKEEIGEHP 366 Query: 367 VVTAVRGKGLLNAIVIKETKDW-------DAWKVCLRLRDNGLLAK------PTHGDIIR 413 +V +RGKGLL I + K+ V ++ GL+ + +I+ Sbjct: 367 LVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVNACKEKGLIIGRNGMTTAGYNNILT 426 Query: 414 FAPPLVIKEDELRESIEIINKTIL 437 APPLVI +E+ I + + Sbjct: 427 LAPPLVISSEEIAFVIGTLKTAME 450 >4ADC-A nrPDB Length = 406 Score = 402 bits (1033), Expect = e-112, Method: Composition-based stats. Identities = 129/387 (33%), Positives = 185/387 (47%), Gaps = 6/387 (1%) Query: 55 YHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRA 114 Y P P RG+G LWD +G++Y DF + GH HP++ AL Q K T Sbjct: 18 YAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNG 77 Query: 115 FYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAA 174 + N + + + +V N+G EA E A KLARK+ + G +K+ IV Sbjct: 78 YTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYG--SHKSGIVAFK 135 Query: 175 GNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQG 234 F GRTL +S+ P F P YND+ + AL D + A +VEPIQG Sbjct: 136 NAFHGRTLFTVSAGGQPAYSQDFAPLPADIRHAAYNDINSAS-ALIDDSTCAVIVEPIQG 194 Query: 235 EAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKAL 294 E GVV +L G+RELC RH L I DE+QTG+ RTG A + V PD++ KAL Sbjct: 195 EGGVVPASNAFLQGLRELCNRHNALLIFDEVQTGVGRTGELYAYMHYGVTPDLLTTAKAL 254 Query: 295 SGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGI 354 GG +PV A+L ++ + G HG+TYGGNPL VA LE++ + + Sbjct: 255 GGG-FPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHD 313 Query: 355 ILRNELMKLPSD--VVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDII 412 L + + + VRG GLL V+ A ++ G++ G+++ Sbjct: 314 WFVERLNTINHRYGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVV 373 Query: 413 RFAPPLVIKEDELRESIEIINKTILSF 439 RFAP L + E+E+ ++ F Sbjct: 374 RFAPALNVSEEEVTTGLDRFAAACEHF 400 >6IO1-A nrPDB Length = 451 Score = 402 bits (1032), Expect = e-112, Method: Composition-based stats. Identities = 126/445 (28%), Positives = 198/445 (44%), Gaps = 48/445 (10%) Query: 39 TSDDIFEREYKYGAHNYHPL-------PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQG 91 + ++ ++ + H L P+ L RG+G+++WD EG++Y D + VN G Sbjct: 7 NAAELVAKDIAHHLHPLTNLYQLRREGPLVLVRGEGVWVWDAEGKRYLDGFAGLWNVNIG 66 Query: 92 HCHPKIVNALKSQVDKLTLTSRAF--YNNVLGEYEEYITKLFN--YHKVLPMNTGVEAGE 147 H ++ A + Q++++ F + E + +LF + G E+ E Sbjct: 67 HGRRELAEAAREQMERVAFVPTFFGLASPPTIELAARLAELFPGPLDHFQFTSGGAESNE 126 Query: 148 TACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDII 207 TA K+AR + + Q + KI+ + G + A+S++ P ++GFGP PGF + Sbjct: 127 TAIKIARYYWWL--KGQPERVKILSRRMAYHGIAMGALSATGVPAYWEGFGPRPPGFIHL 184 Query: 208 --PY------------------NDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLM 247 PY +L +AAF+ EP+QG GVVVP GY Sbjct: 185 TAPYKYRFGEGLTDEEFVARLVQELEETIEREGSETIAAFIGEPVQGAGGVVVPPDGYWP 244 Query: 248 GVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCD 307 + + ++ +L I DE+ TG RTG + V+PDIV K ++ G P+ V Sbjct: 245 AIAAVLRKYGILLILDEVITGFGRTGTLFGMQQYGVQPDIVTFAKGITSGYVPLGGVGVS 304 Query: 308 DDIMLTIKPGE----HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKL 363 D+I T+ + HG TY G+P+ C VA+ L++L E L ENA G L EL +L Sbjct: 305 DEIAETLASADRVFMHGFTYSGHPVACAVALRNLDILLAERLWENAAASGAYLLQELKRL 364 Query: 364 PSD-VVTAVRGKGLLNAIVIKETKDWD---------AWKVCLRLRDNGLLAKPTHGDIIR 413 V VRGKGL+ + + K K+ R G++ + T D I Sbjct: 365 EERPYVGEVRGKGLMLLVEVVRDKASKEKFPPEFKLGPKLEAATRRRGIIVRCTP-DGIV 423 Query: 414 FAPPLVIKEDELRESIEIINKTILS 438 APPL I E IE + + Sbjct: 424 MAPPLTISRAECDVLIEGVAAALSD 448 >5KR3-A nrPDB Length = 479 Score = 398 bits (1023), Expect = e-111, Method: Composition-based stats. Identities = 123/463 (26%), Positives = 198/463 (42%), Gaps = 71/463 (15%) Query: 37 PPTSDDIFEREYKYGAHNYHP-----------LP-VALERGKGIYLWDVEGRKYFDFLSS 84 + D +FE + AH HP LP + GKGI + D EGR+Y D + Sbjct: 21 MQSLDQLFEMDR---AHFMHPSTHAHDHASGALPGRIITGGKGIRIEDHEGREYIDAFAG 77 Query: 85 YSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKL----------FNYH 134 VN G+ ++ +A+ Q +L A+Y+ +G + I +L Sbjct: 78 LYCVNIGYGRTEVADAIYEQAKQL-----AYYHTYVGHSTDAIIELSSRIIRDWAPAGMK 132 Query: 135 KVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSY 194 KV +G +A ET KL W Y + K KI+ + G + S + P+ + Sbjct: 133 KVYYGMSGSDANETQIKLV--WYYNNVLGRPNKKKIISRERGYHGSGIVTGSLTGLPSFH 190 Query: 195 DGFGPFMPGFDI--IPY------------------NDLPALERALQDPNVAAFMVEPIQG 234 F + P+ +L L +AAF+ EP+ G Sbjct: 191 QHFDLPIDRVKHTVCPHWYRAPAGMSEAQFVAYCVEELEKLIAREGADTIAAFIAEPVMG 250 Query: 235 EAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKAL 294 G++ P GY ++ + +H +L IADE+ G R G + + ++PD++ + K L Sbjct: 251 TGGIIPPPQGYWEAIQAVLRKHDILLIADEVVCGFGRLGSKMGSQHYGIKPDLITVAKGL 310 Query: 295 SGGLYPVSAVLCDDDIMLTIKPG-------EHGSTYGGNPLGCRVAIAALEVLEEENLAE 347 + P+S V+ + + I+ G HG TY G+P+ A+A L++LE ENL Sbjct: 311 TSAYAPLSGVIVGEKVWDVIEKGSQEHGPMGHGWTYSGHPICAAAALANLDILERENLTG 370 Query: 348 NADKLGIILRNELMKL--PSDVVTAVRGKGLLNAIVIKETKDWD---------AWKVCLR 396 NA +G L+ L + +V VRG G+L A+ KD KV Sbjct: 371 NAADVGAYLQQRLHEAFGAHPLVGEVRGVGMLAALEFMADKDARTPFDPALKVGPKVSAA 430 Query: 397 LRDNGLLAKPT-HGDIIRFAPPLVIKEDELRESIEIINKTILS 438 ++G++A+ HGDI+ FAPPLV E+ E + I + + Sbjct: 431 ALEDGMIARAMPHGDILGFAPPLVTTRAEVDEIVGIAKQAVDE 473 >5KR5-A nrPDB Length = 479 Score = 394 bits (1012), Expect = e-110, Method: Composition-based stats. Identities = 121/459 (26%), Positives = 195/459 (42%), Gaps = 71/459 (15%) Query: 41 DDIFEREYKYGAHNYHP-----------LP-VALERGKGIYLWDVEGRKYFDFLSSYSAV 88 + + E + AH HP LP + GKGI + D EGR+Y D + V Sbjct: 25 EQLLEMDR---AHFMHPSTHAYDHASGALPGRIITGGKGIRIEDHEGREYIDAFAGLYCV 81 Query: 89 NQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKL----------FNYHKVLP 138 N G+ ++ +A+ Q +L A+Y+ +G + + +L KV Sbjct: 82 NIGYGREEVADAIYEQAKQL-----AYYHTYVGHSNDPVIELSSRIIEDWAPAGMKKVFY 136 Query: 139 MNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFG 198 +G +A ET KL W Y + K KI+ ++ G + S + P+ + F Sbjct: 137 GMSGSDANETQIKLV--WYYNNVLGRPNKKKIIARERSYHGSGIVTGSLTGLPSFHQHFD 194 Query: 199 PFMPGFDI--IPY------------------NDLPALERALQDPNVAAFMVEPIQGEAGV 238 + P+ +L L +AAF+ EP+ G G+ Sbjct: 195 LPIDRVKHTVCPHWYNAPPGMSEAQFVAYCVEELEKLIAREGADTIAAFIAEPVMGTGGI 254 Query: 239 VVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGL 298 V P GY ++ + +H +L IADE+ G R G ++ ++PD++ + K L+ Sbjct: 255 VPPPQGYWEAIQAVLRKHDILLIADEVVCGFGRLGSKTGSEHYGIKPDLITVAKGLTSAY 314 Query: 299 YPVSAVLCDDDIMLTIKPG-------EHGSTYGGNPLGCRVAIAALEVLEEENLAENADK 351 P+SAV+ + + I+ G HG TY G+P+ A+A L++LE ENL NA Sbjct: 315 APLSAVIVSEKVWDVIEKGSREHGVMGHGWTYSGHPVCAAAALANLDILERENLTGNAAD 374 Query: 352 LGIILRNELMKL--PSDVVTAVRGKGLLNAIVIKETKDWDAW---------KVCLRLRDN 400 +G L+ L + +V VRG G+L A+ K KV ++ Sbjct: 375 VGAYLQQRLHEAFGAHPLVGEVRGVGMLAALEFMADKGARTPFDPALKVSQKVAAAALED 434 Query: 401 GLLAKPT-HGDIIRFAPPLVIKEDELRESIEIINKTILS 438 GL+ + HGDI+ FAPPLV E+ E + I + Sbjct: 435 GLIVRALPHGDILGFAPPLVTTRAEVDEIVAIAKEAFDE 473 >3NX3-A nrPDB Length = 395 Score = 392 bits (1008), Expect = e-109, Method: Composition-based stats. Identities = 129/400 (32%), Positives = 211/400 (52%), Gaps = 13/400 (3%) Query: 46 REYKYGAH---NYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALK 102 +YK +H Y + LE+G+G+YL+D + +KY DF S G+ H K +K Sbjct: 3 MDYKEQSHIIPTYKRFDIVLEKGQGVYLFDDKAKKYLDFSSGIGVCALGYNHAKFNAKIK 62 Query: 103 SQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKG 162 +QVDKL TS +YN + + + K +V N+G E+ E A K ARK+ + KG Sbjct: 63 AQVDKLLHTSNLYYNENIAAAAKNLAKASALERVFFTNSGTESIEGAMKTARKYAFN-KG 121 Query: 163 IQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDP 222 ++ + + +F GRTL A+S + + F P + G YND+ ++E+ L + Sbjct: 122 VKGG--QFIAFKHSFHGRTLGALSLTANEKYQKPFKPLISGVKFAKYNDISSVEK-LVNE 178 Query: 223 NVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYEN 282 A ++E +QGE G+ + + +R+LC +L IADEIQ G+ R+G++ A ++ Sbjct: 179 KTCAIILESVQGEGGINPANKDFYKALRKLCDEKDILLIADEIQCGMGRSGKFFAYEHAQ 238 Query: 283 VRPDIVLLGKALSGGLYPVSAVLCDDDIM-LTIKPGEHGSTYGGNPLGCRVAIAALEVLE 341 + PDI+ KAL GL V A + + + +++ G+HGSTYGGNPL C A E+ + Sbjct: 239 ILPDIMTSAKALGCGL-SVGAFVINQKVASNSLEAGDHGSTYGGNPLVCAGVNAVFEIFK 297 Query: 342 EENLAENADKLGIILRNELMKLPS--DVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRD 399 EE + EN +KL L L +L + D +G G + + + K KV + ++ Sbjct: 298 EEKILENVNKLTPYLEQSLDELINEFDFCKKRKGLGFMQGLSL--DKSVKVAKVIQKCQE 355 Query: 400 NGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF 439 N LL + +RF PPL+++++ + E E + K + SF Sbjct: 356 NALLLISCGENDLRFLPPLILQKEHIDEMSEKLRKALKSF 395 >6GWI-A nrPDB Length = 462 Score = 389 bits (999), Expect = e-108, Method: Composition-based stats. Identities = 112/448 (25%), Positives = 189/448 (42%), Gaps = 49/448 (10%) Query: 37 PPTSDDIFEREYKYGAHNYHPL-------PVALERGKGIYLWDVEGRKYFDFLSSYSAVN 89 + D + + H + + +G+Y+ D EG + D ++ VN Sbjct: 1 GMQTQDYQALDRAHHLHPFTDFKALGEEGSRVVTHAEGVYIHDSEGNRILDGMAGLWCVN 60 Query: 90 QGHCHPKIVNALKSQVDKLTLTSRAF--YNNVLGEYEEYITKLFN--YHKVLPMNTGVEA 145 G+ ++V A +Q+++L + F + E + L ++V +G EA Sbjct: 61 LGYGRRELVEAATAQLEQLPYYNTFFKTTHPPAVRLAEKLCDLAPAHINRVFFTGSGSEA 120 Query: 146 GETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFD 205 +T ++ R++ Q K I+ + G TL+ +S + GP +PG Sbjct: 121 NDTVLRMVRRYW--ALKGQPDKQWIIGRENAYHGSTLAGMSLGGMAPMHAQGGPCVPGIA 178 Query: 206 II--PY---------------NDLPALER---ALQDPNVAAFMVEPIQGEAGVVVPDPGY 245 I PY ALE L + VAAF+ EP+QG G ++P Y Sbjct: 179 HIRQPYWFGEGRDMSPEAFGQTCAEALEEKILELGEEKVAAFIAEPVQGAGGAIMPPESY 238 Query: 246 LMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVL 305 V+++ ++ +L +ADE+ G R G W + + PD++ + K LS G P+ VL Sbjct: 239 WPAVKKVLAKYDILLVADEVICGFGRLGEWFGSQHYGLEPDLMPIAKGLSSGYLPIGGVL 298 Query: 306 CDDDIMLTI----KPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENA-DKLGIILRNEL 360 D + T+ HG TY G+P VA+ LE+LE E + + D LG L Sbjct: 299 VGDRVAETLIEEGGEFFHGFTYSGHPTCAAVALKNLELLEAEGVVDRVRDDLGPYLAERW 358 Query: 361 MKLP-SDVVTAVRGKGLLNAIVIKE--------TKDWDAWKVCLR-LRDNGLLAKPTHGD 410 L +V R GL+ A+ + K A +C NGL+ + GD Sbjct: 359 ASLVDHPIVGEARSLGLMGALELVADKTTGQRFDKSLGAGNLCRDLCFANGLVMRSV-GD 417 Query: 411 IIRFAPPLVIKEDELRESIEIINKTILS 438 + +PPLVI+ +E+ E +E+ + + Sbjct: 418 TMIISPPLVIRREEIDELVELARRALDE 445 >5TI8-A nrPDB Length = 474 Score = 388 bits (997), Expect = e-108, Method: Composition-based stats. Identities = 114/447 (25%), Positives = 198/447 (44%), Gaps = 49/447 (10%) Query: 36 GPPTSDDIFEREYKYGAHNYHPLP----------VALERGKGIYLWDVEGRKYFDFLSSY 85 TS + H+ P + + +G+YLWD EG K D ++ Sbjct: 22 TKQTSAQTQHWQALSREHHLAPFTDYKQLNEKGARIITKAEGVYLWDSEGNKILDGMAGL 81 Query: 86 SAVNQGHCHPKIVNALKSQVDKLTLTSRAF--YNNVLGEYEEYITKLF--NYHKVLPMNT 141 +N G+ ++ Q+ +L + F + E + I + + V + Sbjct: 82 WCMNVGYGRKELAEVAYKQMLELPYYNLFFQTAHPPALELAKAIADIAPEGMNHVFFTGS 141 Query: 142 GVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFM 201 G E+ +T ++ R + +++KG + K ++ + G T++ +S + + Sbjct: 142 GSESNDTVLRMVRHY-WSIKG-KPQKKVVIGRWNGYHGSTVAGVSLGGMKALHSQGDLPI 199 Query: 202 PGFDII--PY------------------NDLPALERALQDPNVAAFMVEPIQGEAGVVVP 241 PG I PY L + + NVAAF+ EPIQG GV+VP Sbjct: 200 PGIVHIAQPYWYGEGGDMSAEEFGVWAAEQLEKKILEVGEENVAAFIAEPIQGAGGVIVP 259 Query: 242 DPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPV 301 Y +RE+ ++++LFIADE+ G RTG W Y PD++ + K L+ G P+ Sbjct: 260 PDTYWPKIREILAKYEILFIADEVICGFGRTGEWFGSQYYGNAPDLMPIAKGLTSGYIPM 319 Query: 302 SAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAALEVLEEENLAENA-DKLGIILR 357 V+ D+I+ T+ G HG TY G+P+ VA+ + +L EE + E + L+ Sbjct: 320 GGVIVRDEIVDTLNEGGEFYHGFTYSGHPVAAAVALENIRILREEKIVETVKAETAPYLQ 379 Query: 358 NELMKLP-SDVVTAVRGKGLLNAIVI---KETKDWDAWKVCLRLRD----NGLLAKPTHG 409 +L +V RG G++ A+ + K+T++ V + R+ NGL+ + G Sbjct: 380 KRWQELADHPLVGEARGVGMVGALELVKNKKTRERFENGVGMLCREHCFRNGLIMRAV-G 438 Query: 410 DIIRFAPPLVIKEDELRESIEIINKTI 436 D + +PPLVI + E+ E I + K + Sbjct: 439 DTMIISPPLVITKPEIDELITLARKCL 465 >6FYQ-A nrPDB Length = 484 Score = 387 bits (995), Expect = e-108, Method: Composition-based stats. Identities = 122/442 (27%), Positives = 209/442 (47%), Gaps = 43/442 (9%) Query: 37 PPTSDDIFEREYKYGAHNYHPL--------PVALERGKGIYLWDVEGRKYFDFLSSYSAV 88 P T + E + K+ H + + V ++ G GIYL DV G+ Y D +SS V Sbjct: 34 PFTMRSLTELDKKHFIHPFSSIQEQQHKGAKVIMKEGDGIYLTDVTGKTYIDGVSSLWNV 93 Query: 89 NQGHCHPKIVNALKSQVDKLTLTSRA--FYNNVLGEYEEYITKLF--NYHKVLPMNTGVE 144 N GH ++ A Q+ K+ +S F + E I + + V + G E Sbjct: 94 NVGHGRVELAEAAAQQMKKMAFSSAFSTFSHEPAIRLAEKIASITPEGLNAVFFTSGGSE 153 Query: 145 AGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGF 204 + ++A KL R + + K KI+ ++ G ++ S + P + G M F Sbjct: 154 SNDSAVKLVRHYWKIQ--GKPNKRKIISLKRSYHGVAAASTSVTGIPEFWGMAGHMMTDF 211 Query: 205 DIIPYNDLPALERAL----------QDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCT 254 + + E+A+ +AAF EP+QG GV++P Y + +RE+C Sbjct: 212 LHVDTHYNNTTEQAVQSLCQAIEEAGPETIAAFFAEPVQGAGGVIIPPEDYFLRIREVCN 271 Query: 255 RHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTI 314 + +LF+ADE+ TG RTG+ ++ +V PD++ K ++ G +P+ V+ D I + Sbjct: 272 AYGILFVADEVITGFGRTGKMFGIENWDVIPDVMTFAKGVTSGYFPLGGVVVSDPIHEVL 331 Query: 315 KPGE-----HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDV-- 367 K HG TY G+P VA+ + +++EE L EN+ ++G L + L K+ + + Sbjct: 332 KEKSVGTLFHGFTYSGHPTAAAVALKNIAIIKEERLVENSKRMGDALLHGLKKVKNRLEI 391 Query: 368 VTAVRGKGLLNAIVIKETKDWD---------AWKVCLRLRDNGLLAKPT---HGDIIRFA 415 V VR GLL A+ + + + A KV L + G++ + H +II A Sbjct: 392 VGDVRFVGLLGAVELMQNPATNKPFSSNLQVAPKVIEALHELGVICRSVTYDHTNIICLA 451 Query: 416 PPLVIKEDELRESIEIINKTIL 437 PPL+I + ++ + +E+I + IL Sbjct: 452 PPLIINQKQVDKLVEVIYEAIL 473 >6G4F-A nrPDB Length = 464 Score = 385 bits (989), Expect = e-107, Method: Composition-based stats. Identities = 112/451 (24%), Positives = 209/451 (46%), Gaps = 52/451 (11%) Query: 37 PPTSDDIFEREYKYGAHNYHPL-------PVALERGKGIYLWDVEGRKYFDFLSSYSAVN 89 + + E++ +Y H Y P+ +ERG+GIY++D +G+ Y + ++ + Sbjct: 2 NQSVSSLPEKDIQYQLHPYTNARLHQELGPLIIERGEGIYVYDDQGKGYIEAMAGLWSAA 61 Query: 90 QGHCHPKIVNALKSQVDKLTLTSRAFY--NNVLGEYEEYITKL--FNYHKVLPMNTGVEA 145 G + +++ A + Q + L + + E E + ++ KV N+G EA Sbjct: 62 LGFSNQRLIKAAEQQFNTLPFYHLFSHKSHRPSIELAEKLIEMAPVPMSKVFFTNSGSEA 121 Query: 146 GETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFD 205 +T K+ W + K K + + G T+++ S + P + GF +PGF Sbjct: 122 NDTVVKMV--WYLNNALGKPAKKKFISRVNGYHGITVASASLTGLPGNQRGFDLPLPGFL 179 Query: 206 II--PYN-------------------DLPALERALQDPNVAAFMVEPIQGEAGVVVPDPG 244 + P++ +L A +AAF+ EP+ G GV+VP Sbjct: 180 HVGCPHHYRFALAGESEEHFADRLAVELEQKILAEGPETIAAFIGEPLMGAGGVIVPPRT 239 Query: 245 YLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAV 304 Y ++++C ++ +L IADE+ G RTG+ ++PDI++L K LS P++A+ Sbjct: 240 YWEKIQKVCRKYDILVIADEVICGFGRTGQMFGSQTFGIQPDIMVLSKQLSSSYQPIAAI 299 Query: 305 LCDDDIMLTIK-------PGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILR 357 L + + I HG T G+P+ VA+ L+++EEE+L E+A ++G +LR Sbjct: 300 LINAPVFEGIADQSQALGALGHGFTGSGHPVATAVALENLKIIEEESLVEHAAQMGQLLR 359 Query: 358 NELMK-LPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCL---------RLRDNGLLAKPT 407 + L + +V +RG GL+ A+ + + A L R +++G++ + Sbjct: 360 SGLQHFIDHPLVGEIRGCGLIAAVELVGDRVSKAPYQALGTLGRYMAGRAQEHGMITRAM 419 Query: 408 HGDIIRFAPPLVIKEDELRESIEIINKTILS 438 GD + F PPL++ E E+ +E + + Sbjct: 420 -GDAVAFCPPLIVNEQEVGMIVERFARALDD 449 >5KQU-A nrPDB Length = 479 Score = 383 bits (985), Expect = e-107, Method: Composition-based stats. Identities = 123/459 (26%), Positives = 194/459 (42%), Gaps = 71/459 (15%) Query: 41 DDIFEREYKYGAHNYHP-----------LP-VALERGKGIYLWDVEGRKYFDFLSSYSAV 88 D +FE++ AH HP LP + GI + D EGR+ D + V Sbjct: 25 DQLFEQDR---AHFMHPSTHAHDHASGALPGRIITGASGIRIRDHEGRELIDAFAGLYCV 81 Query: 89 NQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKL----------FNYHKVLP 138 N G+ ++ +A+ Q +L A+Y+ +G E I +L KV Sbjct: 82 NIGYGRTEVADAIYKQAKEL-----AYYHTYVGHSTEAIIELSSRIIRDWAPAGMKKVYY 136 Query: 139 MNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFG 198 +G +A ET KL R Y + K KI+ + G + S + P+ + F Sbjct: 137 GLSGSDANETQIKLVR--YYNNVLGRPQKKKIISRQRGYHGSGIMTGSLTGLPSFHQHFD 194 Query: 199 PFMPGFDI--IPY------------------NDLPALERALQDPNVAAFMVEPIQGEAGV 238 + G P+ ++L L A VAAF+ EP+ G G+ Sbjct: 195 LPVEGIKHTVCPHWYKAPAGMDEAAFVRYCADELEKLILAEGPDTVAAFIGEPVMGTGGI 254 Query: 239 VVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGL 298 +VP GY ++ + ++ VL IADE+ R G + +RPD++ K L+ Sbjct: 255 IVPPKGYWEAIQAVLNKYDVLLIADEVVCAFGRLGSKMGSQRYGMRPDLITTAKGLTSAY 314 Query: 299 YPVSAVLCDDDIMLTIKPG-------EHGSTYGGNPLGCRVAIAALEVLEEENLAENADK 351 P+SAV+ + + I+ HG TY G+P+ A+A L++LE ENL NA Sbjct: 315 APLSAVIVGEKVWDVIEKASQKEGAMGHGWTYSGHPICAAAALANLDILERENLTANAAD 374 Query: 352 LGIILRNELMK--LPSDVVTAVRGKGLLNAIVIKETKDWD---------AWKVCLRLRDN 400 +G L L + +V VRG G+L A+ ++ KV ++ Sbjct: 375 VGAYLNQRLRETFEGHPLVGEVRGDGMLAALEFMADREARTPFDPALKVGPKVSAACLED 434 Query: 401 GLLAKPT-HGDIIRFAPPLVIKEDELRESIEIINKTILS 438 G++A+ HGDI+ FAPPLV+ E E + I + Sbjct: 435 GMIARAMPHGDILGFAPPLVLTRAEADEIVGIAKAAVDE 473 >5GHG-A nrPDB Length = 456 Score = 380 bits (977), Expect = e-106, Method: Composition-based stats. Identities = 113/448 (25%), Positives = 196/448 (43%), Gaps = 52/448 (11%) Query: 40 SDDIFEREYKYGAHNYHPL-------PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGH 92 + + R+ +Y H+Y P+ +ERG GIY+ DV G++Y + +S +V G Sbjct: 5 PNSLEARDIRYHLHSYTDAVRLEAEGPLVIERGDGIYVEDVSGKRYIEAMSGLLSVGVGF 64 Query: 93 CHPKIVNALKSQVDKLTLTSRAFY--NNVLGEYEEYITKL--FNYHKVLPMNTGVEAGET 148 P++ A Q+ KL Y + + + E + + K N+G EA +T Sbjct: 65 SEPRLAEAAARQMKKLPFYHTFSYRSHGPVIDLAEKLVSMAPVPMSKAYFTNSGSEANDT 124 Query: 149 ACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDI-- 206 KL W + + + KI+ + G T+++ S + P ++ F + Sbjct: 125 VVKLI--WYRSNALGEPERKKIISRKRGYHGVTIASASLTGLPNNHRSFDLPIDRILHTG 182 Query: 207 IPY-------------------NDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLM 247 P+ ++L L A +AAF+ EP+ G GVVVP Y Sbjct: 183 CPHFYREGQAGESEEQFATRLADELEQLIIAEGPHTIAAFIGEPVMGAGGVVVPPKTYWE 242 Query: 248 GVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCD 307 V+ + R+ +L IADE+ G RTG +++PDI+++ K LS P+SA L + Sbjct: 243 KVQAVLKRYDILLIADEVICGFGRTGNLFGSQTFDMKPDILVMSKQLSSSYLPISAFLIN 302 Query: 308 DDIMLTIKPGEH-------GSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNEL 360 + + I H G T G+P+ VA+ L ++EE +L NA G ++ L Sbjct: 303 ERVYAPIAEESHKIGTLGTGFTASGHPVAAAVALENLAIIEERDLVANARDRGTYMQKRL 362 Query: 361 MKLP-SDVVTAVRGKGLLNAIVIKETKDWD---------AWKVCLRLRDNGLLAKPTHGD 410 +L +V VRG GL+ + + K K L++ G++++ GD Sbjct: 363 RELQDHPLVGEVRGVGLIAGVELVTDKQAKTGLEPTGALGAKANAVLQERGVISRAM-GD 421 Query: 411 IIRFAPPLVIKEDELRESIEIINKTILS 438 + F PPL+I + ++ + + T+ Sbjct: 422 TLAFCPPLIINDQQVDTMVSALEATLND 449 >4BQ0-A nrPDB Length = 448 Score = 373 bits (958), Expect = e-104, Method: Composition-based stats. Identities = 115/441 (26%), Positives = 190/441 (43%), Gaps = 44/441 (9%) Query: 36 GPPTSDDIFEREY--KYGAH-NYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGH 92 PP S ++ R + + A+ N+ P + +G +L D +GRK +D LS GH Sbjct: 8 APPVSSELNLRAHWMPFSANRNFQKDPRIIVAAEGSWLTDDKGRKVYDSLSGLWTCGAGH 67 Query: 93 CHPKIVNALKSQVDKLTLTSRAFYNNVLG-EYEEYITKLF--NYHKVLPMNTGVEAGETA 149 +I A+ Q+ L + Y + L + E I L + V +G E +T+ Sbjct: 68 SRKEIQEAVARQLGTLDYSPGFQYGHPLSFQLAEKIAGLLPGELNHVFFTGSGSECADTS 127 Query: 150 CKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPY 209 K+AR + Q K K++ A + G ++ S + FG M D +P+ Sbjct: 128 IKMARAYWRL--KGQPQKTKLIGRARGYHGVNVAGTSLGGIGGNRKMFGQLM-DVDHLPH 184 Query: 210 ---------------------NDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMG 248 N+L L N+AA +VEP+ G AGV+VP GYL Sbjct: 185 TLQPGMAFTRGMAQTGGVELANELLKLIELHDASNIAAVIVEPMSGSAGVLVPPVGYLQR 244 Query: 249 VRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDD 308 +RE+C +H +L I DE+ T R G + +Y V PD++ + K ++ G P+ AV+ Sbjct: 245 LREICDQHNILLIFDEVITAFGRLGTYSGAEYFGVTPDLMNVAKQVTNGAVPMGAVIASS 304 Query: 309 DIMLTIK---------PGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNE 359 +I T HG TY +P+ C +AAL++L +NL + + +L Sbjct: 305 EIYDTFMNQALPEHAVEFSHGYTYSAHPVACAAGLAALDILARDNLVQQSAELAPHFEKG 364 Query: 360 LMKLP-SDVVTAVRGKGLLNAIVIKE---TKDWDAWKVCLRLRDNGLLAKPTHGDIIRFA 415 L L + V +R GL AI I ++ ++L G + GD ++F Sbjct: 365 LHGLQGAKNVIDIRNCGLAGAIQIAPRDGDPTVRPFEAGMKLWQQGFYVR-FGGDTLQFG 423 Query: 416 PPLVIKEDELRESIEIINKTI 436 P + +EL + + + + Sbjct: 424 PTFNARPEELDRLFDAVGEAL 444 >5X3F-A nrPDB Length = 501 Score = 371 bits (954), Expect = e-103, Method: Composition-based stats. Identities = 124/383 (32%), Positives = 204/383 (53%), Gaps = 21/383 (5%) Query: 70 LWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITK 129 L D +G+++ D L + N GH +P +V+A+++Q+ K L S+ + + + + Sbjct: 74 LVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVQNQLAKQPLHSQELLDPLRAMLAKTLAA 133 Query: 130 LFN--YHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISS 187 L N+G E+ E A KLA+ + + K + +G F G++L A+S+ Sbjct: 134 LTPGKLKYSFFCNSGTESVEAALKLAKAYQS-----PRGKFTFIATSGAFHGKSLGALSA 188 Query: 188 STDPTSYDGFGPFMPGFDIIPYNDLPALERALQD-----PNVAAFMVEPIQGEAGVVVPD 242 + T F P +PGF +P+ ++ A+ AL + +VAA ++EPIQGE GV++P Sbjct: 189 TAKSTFRKPFMPLLPGFRHVPFGNIEAMRTALNECKKTGDDVAAVILEPIQGEGGVILPP 248 Query: 243 PGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVS 302 PGYL VR+LC L I DE+QTG+ RTG+ A ++ENV+PDI+ L KAL GG+ P+ Sbjct: 249 PGYLTAVRKLCDEFGALMILDEVQTGMGRTGKMFACEHENVQPDILCLAKALGGGVMPIG 308 Query: 303 AVLCDDDIMLTI--KPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNEL 360 A + +++ + P H +T+GGNPL C A+A + VL E+NL A++ G +L + Sbjct: 309 ATIATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLLEQNLPAQAEQKGDMLLDGF 368 Query: 361 MKLPS---DVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGD--IIRFA 415 +L D+V RGKG+L AI + + + + +L T + IR Sbjct: 369 RQLAREYPDLVQEARGKGMLMAIEFVDNE--IGYNFASEMFRQRVLVAGTLNNAKTIRIE 426 Query: 416 PPLVIKEDELRESIEIINKTILS 438 PPL + ++ I+ K + + Sbjct: 427 PPLTLTIEQCELVIKAARKALAA 449 >4UHN-A nrPDB Length = 468 Score = 370 bits (950), Expect = e-103, Method: Composition-based stats. Identities = 119/455 (26%), Positives = 202/455 (44%), Gaps = 45/455 (9%) Query: 22 VASATSVATKKTVQGPPTSDDIFEREY--KYGAH-NYHPLPVALERGKGIYLWDVEGRKY 78 V + + + V P + D+ + + + A+ N+H P + +G +L D +GR+ Sbjct: 15 VPRGSHMNQQVNV-APSAAADLNLKAHWMPFSANRNFHKDPRIIVAAEGSWLVDDKGRRI 73 Query: 79 FDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLG-EYEEYITKLFN--YHK 135 +D LS GH +I +A+ Q+ L + Y + L + E I ++ Sbjct: 74 YDSLSGLWTCGAGHSRKEIADAVAKQIGTLDYSPGFQYGHPLSFQLAEKIAQMTPGTLDH 133 Query: 136 VLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYD 195 V +G E +T+ K+AR + + +KG Q K K++ A + G ++ S + Sbjct: 134 VFFTGSGSECADTSIKMARAY-WRIKG-QAQKTKLIGRARGYHGVNVAGTSLGGIGGNRK 191 Query: 196 GFGPFMPGFDIIPY---------------------NDLPALERALQDPNVAAFMVEPIQG 234 FGP M D +P+ N+L L N+AA +VEP+ G Sbjct: 192 MFGPLM-DVDHLPHTLQPGMAFTKGAAETGGVELANELLKLIELHDASNIAAVIVEPMSG 250 Query: 235 EAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKAL 294 AGV+VP GYL +RE+C + +L I DE+ T R G+ +Y V PDI+ + K + Sbjct: 251 SAGVIVPPKGYLQRLREICDANDILLIFDEVITAFGRMGKATGAEYFGVTPDIMNVAKQV 310 Query: 295 SGGLYPVSAVLCDDDIMLTIK---------PGEHGSTYGGNPLGCRVAIAALEVLEEENL 345 + G P+ AV+ +I T HG TY +P+ C IAAL++L++ENL Sbjct: 311 TNGAVPMGAVIASSEIYDTFMNQNLPEYAVEFGHGYTYSAHPVACAAGIAALDLLQKENL 370 Query: 346 AENADKLGIILRNELMKLP-SDVVTAVRGKGLLNAIVIKE---TKDWDAWKVCLRLRDNG 401 + + +L L L + V +R GL AI I ++ ++L G Sbjct: 371 IQQSAELAPHFEKALHGLKGTKNVIDIRNCGLAGAIQIAARDGDAIVRPFEASMKLWKEG 430 Query: 402 LLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTI 436 + GD ++F P K ++L + + + + Sbjct: 431 FYVR-FGGDTLQFGPTFNAKPEDLDRLFDAVGEAL 464 >4BA4-A nrPDB Length = 459 Score = 368 bits (944), Expect = e-102, Method: Composition-based stats. Identities = 109/452 (24%), Positives = 188/452 (41%), Gaps = 49/452 (10%) Query: 34 VQGPPTSDDIFEREYKYGAHNYHPLP-------VALERGKGIYLWDVEGRKYFDFLSSYS 86 +Q T+ E + + H + + RG+G+YLWD EG K D ++ Sbjct: 1 MQKQRTTSQWRELDAAHHLHPFTDTASLNQAGARVMTRGEGVYLWDSEGNKIIDGMAGLW 60 Query: 87 AVNQGHCHPKIVNALKSQVDKLTLTSRAF--YNNVLGEYEEYITKLF--NYHKVLPMNTG 142 VN G+ A + Q+++L + F + + E + ++ + +V N+G Sbjct: 61 CVNVGYGRKDFAEAARRQMEELPFYNTFFKTTHPAVVELSSLLAEVTPAGFDRVFYTNSG 120 Query: 143 VEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMP 202 E+ +T ++ R++ + K ++ + G T+ S ++ +P Sbjct: 121 SESVDTMIRMVRRYW--DVQGKPEKKTLIGRWNGYHGSTIGGASLGGMKYMHEQGDLPIP 178 Query: 203 G--------------------FDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPD 242 G F ++ L + VAAF+ EPIQG GV+VP Sbjct: 179 GMAHIEQPWWYKHGKDMTPDEFGVVAARWLEEKILEIGADKVAAFVGEPIQGAGGVIVPP 238 Query: 243 PGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVS 302 Y + +C ++ VL +ADE+ G RTG W + +PD+ K LS G P+ Sbjct: 239 ATYWPEIERICRKYDVLLVADEVICGFGRTGEWFGHQHFGFQPDLFTAAKGLSSGYLPIG 298 Query: 303 AVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAALEVLEEENLAENA-DKLGIILRN 358 AV + + G HG TY G+P+ VA A + L +E + + D +G ++ Sbjct: 299 AVFVGKRVAEGLIAGGDFNHGFTYSGHPVCAAVAHANVAALRDEGIVQRVKDDIGPYMQK 358 Query: 359 ELMKLPSDV--VTAVRGKGLLNAIVIKETKD-----WDAWKVCLRLRD----NGLLAKPT 407 + S V VRG G++ A + + K D ++ RD N L+ + Sbjct: 359 RWRETFSRFEHVDDVRGVGMVQAFTLVKNKAKRELFPDFGEIGTLCRDIFFRNNLIMRAC 418 Query: 408 HGDIIRFAPPLVIKEDELRESIEIINKTILSF 439 GD I APPLV+ E+ E + + + + F Sbjct: 419 -GDHIVSAPPLVMTRAEVDEMLAVAERCLEEF 449 >5LL2-A nrPDB Length = 480 Score = 368 bits (944), Expect = e-102, Method: Composition-based stats. Identities = 121/437 (27%), Positives = 206/437 (47%), Gaps = 50/437 (11%) Query: 39 TSDDIFEREYKYGAH----NYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCH 94 + + + E KY A NY+ + ++ G L DV+G KY D L+S SA+N GH H Sbjct: 36 KASKLIDEENKYYARSARINYYN--LVIDHAHGATLVDVDGNKYIDLLASASAINVGHTH 93 Query: 95 PKIVNALKSQVDKLTLTSRAFYNNVLG-EYEEYITKLFNYH---KVLPMNTGVEAGETAC 150 K+V A+ Q KL + A++++V G E E + K+ + V N+G +A + Sbjct: 94 EKVVKAIADQAQKLIHYTPAYFHHVPGMELSEKLAKIAPGNSPKMVSFGNSGSDANDAII 153 Query: 151 KLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTS-YDGFGPFMPGFDIIPY 209 K AR + + IV G++ G T + + S + GP +P +PY Sbjct: 154 KFARAY--------TGRQYIVSYMGSYHGSTYGSQTLSGSSLNMTRKIGPMLPSVVHVPY 205 Query: 210 NDLPA---------------------LERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMG 248 D E L A ++EPIQG+ G++ Y+ Sbjct: 206 PDSYRTYPGETEHDVSLRYFNEFKKPFESFLPADETACVLIEPIQGDGGIIKAPEEYMQL 265 Query: 249 VRELCTRHQVLFIADEIQTGLARTGRWLAVDYE-NVRPDIVLLGKALSGGLYPVSAVLCD 307 V + C H +LF DE+ GL RTG+ A+ ++ PD++ +GK+L+ G+ P+SAV+ Sbjct: 266 VYKFCHEHGILFAIDEVNQGLGRTGKMWAIQQFKDIEPDLMSVGKSLASGM-PLSAVIGK 324 Query: 308 DDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLP--S 365 ++M ++ H T GNP+ ++A L+V+E E L E + G + +++ Sbjct: 325 KEVMQSLDAPAHLFTTAGNPVCSAASLATLDVIEYEGLVEKSATDGAYAKQRFLEMQQRH 384 Query: 366 DVVTAVRGKGLLNAIVIKET-----KDWDAW-KVCLRLRDNGLLAKPTHGDIIRFAPPLV 419 ++ VR GL I + + D DA KV +G++ G+I+RF PPLV Sbjct: 385 PMIGDVRMWGLNGGIELVKDPKTKEPDSDAATKVIYYAFAHGVVIITLAGNILRFQPPLV 444 Query: 420 IKEDELRESIEIINKTI 436 I ++L +++++++ Sbjct: 445 IPREQLDQALQVLDDAF 461 >5LH9-A nrPDB Length = 458 Score = 367 bits (943), Expect = e-102, Method: Composition-based stats. Identities = 115/422 (27%), Positives = 189/422 (44%), Gaps = 47/422 (11%) Query: 60 VALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRA--FYN 117 + + RG G Y+ D++G++ D + VN GH + A+ +Q+D+L + Sbjct: 37 LVIARGDGNYITDIDGQRMLDGVGGLWNVNIGHNRASVKAAIAAQLDELAYYQTFDGIAH 96 Query: 118 NVLGEYEEYITKLFN---YHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAA 174 + + E +T +F +VL + G +A ETA K+AR++ + + + + + Sbjct: 97 PRVFDLAERLTGMFAQERMARVLFSSGGSDAVETALKMARQYW--IASGEPGRTRFLSLR 154 Query: 175 GNFWGRTLSAISSSTDPTSYDGFGPFMPGFDII--------PYND-------------LP 213 + G + S + + G + G ++ P++ L Sbjct: 155 NGYHGVHMGGTSVGGNGVYHYNHGQLLAGCHLLDTPWLYRNPWDCRDPQALTAHCIRQLE 214 Query: 214 ALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTG 273 L +AA + EP+QG GV+VP Y +RE+C RH +L IADE+ TG R+G Sbjct: 215 EQIALLGAQTIAALIAEPVQGAGGVIVPPADYWPRLREVCDRHGILLIADEVVTGFGRSG 274 Query: 274 RWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE-------HGSTYGGN 326 L V PDI+ L K ++ G P+ A L + I I+ G+ HG TY G+ Sbjct: 275 CMLGSRGWGVAPDILCLAKGITAGYIPLGATLFNQRIADAIENGQGFSHMIMHGYTYSGH 334 Query: 327 PLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSD--VVTAVRGKGLLNAIVIKE 384 P C A+A L+++E E+L NA K+G L +L L VV VRGKGL+ A+ + Sbjct: 335 PTACAAALAVLDIVEAEDLPGNAAKVGAQLLEQLQPLVERYAVVGEVRGKGLMIALDLVS 394 Query: 385 TK---------DWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKT 435 K ++ R G+L +P G+ I +PPL + DE + + Sbjct: 395 DKRTRQPLDPAAGQPSRIADEARRAGVLVRPI-GNKIILSPPLTLTRDEAGLMVSALEAA 453 Query: 436 IL 437 Sbjct: 454 FA 455 >3GJU-A nrPDB Length = 460 Score = 366 bits (940), Expect = e-101, Method: Composition-based stats. Identities = 114/449 (25%), Positives = 180/449 (40%), Gaps = 57/449 (12%) Query: 40 SDDIFEREYKYGAHNYHPLP-VALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIV 98 D F G H P + G+G+ +WD GRK D + VN G+ KI Sbjct: 14 RDHFFHPSTHMGTHARGESPTRIMAGGEGVTVWDNNGRKSIDAFAGLYCVNVGYGRQKIA 73 Query: 99 NALKSQVDKLTLTSRAFYNNVLGEYEEYITKLF---------NYHKVLPMNTGVEAGETA 149 +A+ +Q L A+Y+ +G E L +V +G +A ET Sbjct: 74 DAIATQAKNL-----AYYHAYVGHGTEASITLAKMIIDRAPKGMSRVYFGLSGSDANETN 128 Query: 150 CKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDI--I 207 KL W Y + K KI+ + G + S + ++ F Sbjct: 129 IKLI--WYYNNVLGRPEKKKIISRWRGYHGSGVMTGSLTGLDLFHNAFDLPRAPVLHTEA 186 Query: 208 PY-------------------NDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMG 248 PY + L + A +AAF+ EPI G G+V P GY Sbjct: 187 PYYFRRTDRSMSEEQFSQHCADKLEEMILAEGPETIAAFIGEPILGTGGIVPPPAGYWEK 246 Query: 249 VRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDD 308 ++ + ++ VL +ADE+ TG R G D+ ++PD++ + K L+ P+S V+ D Sbjct: 247 IQAVLKKYDVLLVADEVVTGFGRLGTMFGSDHYGIKPDLITIAKGLTSAYAPLSGVIVAD 306 Query: 309 DIMLTIKPG-------EHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELM 361 + + G HG TY +P+ +A LE+++E +L NA + G R EL Sbjct: 307 RVWQVLVQGSDKLGSLGHGWTYSAHPICVAAGVANLELIDEMDLVTNAGETGAYFRAELA 366 Query: 362 KLP--SDVVTAVRGKGLLNAIVIKETKDWD---------AWKVCLRLRDNGLLAKPT-HG 409 K V VRG G+L A+ KD +V L +G++ + G Sbjct: 367 KAVGGHKNVGEVRGDGMLAAVEFVADKDDRVFFDASQKIGPQVATALAASGVIGRAMPQG 426 Query: 410 DIIRFAPPLVIKEDELRESIEIINKTILS 438 DI+ FAPPL + ++ + + S Sbjct: 427 DILGFAPPLCLTREQADIVVSKTADAVKS 455 >3DOD-A nrPDB Length = 448 Score = 364 bits (935), Expect = e-101, Method: Composition-based stats. Identities = 126/445 (28%), Positives = 208/445 (46%), Gaps = 48/445 (10%) Query: 39 TSDDIFEREYKYGA------HNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGH 92 + D+ E+ K+ +Y P+ +E G GI + D+ G++Y+D SS GH Sbjct: 1 MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGKEYYDGFSSVWLNVHGH 60 Query: 93 CHPKIVNALKSQVDKLTLTSRA-FYNNVLGEYEEYITKLFN--YHKVLPMNTGVEAGETA 149 ++ +A+K Q+ K+ ++ N + E + + +V ++G EA E A Sbjct: 61 RKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPKKLTRVFYSDSGAEAMEIA 120 Query: 150 CKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPY 209 K+A ++ + + K K + + G T+ A+S + + +GP M P Sbjct: 121 LKMAFQYWKNI--GKPEKQKFIAMKNGYHGDTIGAVSVGSIELFHHVYGPLMFESYKAPI 178 Query: 210 ND----------------LPALERALQD--PNVAAFMVEP-IQGEAGVVVPDPGYLMGVR 250 L L + L++ +AA +E +QG +G++V GYL GVR Sbjct: 179 PYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIESMVQGASGMIVMPEGYLAGVR 238 Query: 251 ELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDI 310 ELCT + VL I DE+ TG RTG+ A ++ENV+PD++ GK ++GG P++ +DI Sbjct: 239 ELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLMAAGKGITGGYLPIAVTFATEDI 298 Query: 311 MLTI-------KPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKL 363 K HG +Y GN LGC VA+ L + E EN+ E + L L L Sbjct: 299 YKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLALFESENIVEQVAEKSKKLHFLLQDL 358 Query: 364 PS-DVVTAVRGKGLLNAIVIKETKDWD---------AWKVCLRLRDNGLLAKPTHGDIIR 413 + V +R G + + +K+ +KV L++R+ G+L +P GD+I Sbjct: 359 HALPHVGDIRQLGFMCGAELVRSKETKEPYPADRRIGYKVSLKMRELGMLTRPL-GDVIA 417 Query: 414 FAPPLVIKEDELRESIEIINKTILS 438 F PPL +EL E + I+ + I Sbjct: 418 FLPPLASTAEELSEMVAIMKQAIHE 442 >2EO5-A nrPDB Length = 419 Score = 362 bits (930), Expect = e-100, Method: Composition-based stats. Identities = 122/412 (29%), Positives = 192/412 (46%), Gaps = 51/412 (12%) Query: 58 LPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQG-HCHPKIVNALKSQVDKLTLTS-RAF 115 P+ ++ G+G++++DV+G KY DF S N G HP+++ Q+ KL + F Sbjct: 24 FPLVIDHGEGVWIYDVDGNKYLDFTSGIGVNNLGWPSHPEVIKIGIEQMQKLAHAAANDF 83 Query: 116 YNNVLGEYEEYITKLFNYH---KVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVF 172 YN E + + + KV N+G EA E + K+ + + I+ Sbjct: 84 YNIPQLELAKKLVTYSPGNFQKKVFFSNSGTEAIEASIKVVKN---------TGRKYIIA 134 Query: 173 AAGNFWGRTLSAISSSTDPTSYDG-FGPFMPGFDIIPY--------------NDLPALER 217 G F GRT +IS + GPFMPG +PY N + R Sbjct: 135 FLGGFHGRTFGSISLTASKAVQRSIVGPFMPGVIHVPYPNPYRNPWHINGYENPSELVNR 194 Query: 218 ALQ------------DPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEI 265 ++ VA EPIQGE G V+P + +++L ++ +L + DE+ Sbjct: 195 VIEFIEDYIFVNLVPPEEVAGIFFEPIQGEGGYVIPPKNFFAELQKLAKKYGILLVDDEV 254 Query: 266 QTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGG 325 Q GL RTG+ A++ N PD++ L KAL GG+ P+ A + D+ KPG H +T+GG Sbjct: 255 QMGLGRTGKLFAIENFNTVPDVITLAKALGGGIMPIGATIFRKDL--DFKPGMHSNTFGG 312 Query: 326 NPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKET 385 N L C + +++++ +L + +++G I EL L VRG GL + E Sbjct: 313 NALACAIGSKVIDIVK--DLLPHVNEIGKIFAEELQGLAD----DVRGIGLAWGLEYNEK 366 Query: 386 KDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTIL 437 K D ++ GLL P IR PPLVI E+E ++ ++I+ K I Sbjct: 367 KVRD--RIIGESFKRGLLLLPAGRSAIRVIPPLVISEEEAKQGLDILKKVIK 416 >5KQT-A nrPDB Length = 479 Score = 360 bits (924), Expect = e-100, Method: Composition-based stats. Identities = 113/442 (25%), Positives = 181/442 (40%), Gaps = 57/442 (12%) Query: 40 SDDIFEREYKYGAHNYHPLP-VALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIV 98 H LP + G+ + D +GR+ D + VN G+ ++ Sbjct: 32 RAHFMHPSTHAHDHASGALPGRIITGASGVRIRDHQGRELLDAFAGLYCVNIGYGRLEVA 91 Query: 99 NALKSQVDKLTLTSRAFYNNVLGEYEEYITKL----------FNYHKVLPMNTGVEAGET 148 +A+ Q +L A+Y+ +G E I +L KV +G +A ET Sbjct: 92 DAIHEQAKQL-----AYYHTYVGHASEAIIELSARIIRDWAPAGMKKVYYGLSGSDANET 146 Query: 149 ACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDI-- 206 KL R Y + K KI+ + G + S + + + F + G Sbjct: 147 QVKLVR--YYNNVLGRPQKKKIISRQRGYHGSGIVTGSLTGLASFHQHFDLPVEGVKHTL 204 Query: 207 IPY------------------NDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMG 248 P+ +L L A VAAF+ EP+ G G++VP GY Sbjct: 205 CPHFYKAPAGMDEAAFVRHCAQELENLILAEGPDTVAAFIGEPVMGTGGIIVPPKGYWEA 264 Query: 249 VRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDD 308 ++ + ++ VL IADE+ R G + +RPD++ K L+ P+SAV+ + Sbjct: 265 IQAVLAKYDVLLIADEVVCAFGRLGDKMGSQRHAMRPDLITTAKGLTSAYAPLSAVIVGE 324 Query: 309 DIMLTIKPG-------EHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELM 361 + I HG TY G+P+ A+A L++LE EN+ NA +G L +L Sbjct: 325 KVWDVIDSASTREGAMGHGWTYSGHPICAAAALANLDILERENITANAADVGGYLNQQLR 384 Query: 362 K--LPSDVVTAVRGKGLLNAIVIKETKDWD---------AWKVCLRLRDNGLLAKPT-HG 409 + +V VRG G+L A+ ++ KV + G++A+ HG Sbjct: 385 QAFEGHPLVGEVRGDGMLAALEFMADREARTPFDAALKVGPKVSAACLERGMIARAMPHG 444 Query: 410 DIIRFAPPLVIKEDELRESIEI 431 DI+ FAPPLV+ E E + I Sbjct: 445 DILGFAPPLVLSRAEADEVVGI 466 >3HMU-A nrPDB Length = 472 Score = 359 bits (921), Expect = 2e-99, Method: Composition-based stats. Identities = 101/450 (22%), Positives = 182/450 (40%), Gaps = 47/450 (10%) Query: 33 TVQGPPTSDDIFEREYKYGAHNYH-------PLPVALERGKGIYLWDVEGRKYFDFLSSY 85 T+ + ++ + + H + + R +G++L D EG + D ++ Sbjct: 5 TITNHMPTAELQALDAAHHLHPFSANNALGEEGTRVITRARGVWLNDSEGEEILDAMAGL 64 Query: 86 SAVNQGHCHPKIVNALKSQVDKLTLTSRAF--YNNVLGEYEEYITKLF--NYHKVLPMNT 141 VN G+ ++ Q+ +L + F + + + +L + + V Sbjct: 65 WCVNIGYGRDELAEVAARQMRELPYYNTFFKTTHVPAIALAQKLAELAPGDLNHVFFAGG 124 Query: 142 GVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGP-- 199 G EA +T ++ R + Q K I+ + G T+++ + + G Sbjct: 125 GSEANDTNIRMVRTYWQN--KGQPEKTVIISRKNAYHGSTVASSALGGMAGMHAQSGLIP 182 Query: 200 ----------FMPGFDIIPYN-------DLPALERALQDPNVAAFMVEPIQGEAGVVVPD 242 + G D+ P +L L + VAAF+ EP+QG GV+V Sbjct: 183 DVHHINQPNWWAEGGDMDPEEFGLARARELEEAILELGENRVAAFIAEPVQGAGGVIVAP 242 Query: 243 PGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVS 302 Y ++ +C ++ +L IADE+ G RTG W +RP I+ + K LS G P+ Sbjct: 243 DSYWPEIQRICDKYDILLIADEVICGFGRTGNWFGTQTMGIRPHIMTIAKGLSSGYAPIG 302 Query: 303 AVLCDDDIMLTI--KPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKL-GIILRNE 359 + D++ I HG TY G+P+ VA+ L +LEEEN+ ++ + L+ + Sbjct: 303 GSIVCDEVAHVIGKDEFNHGYTYSGHPVAAAVALENLRILEEENILDHVRNVAAPYLKEK 362 Query: 360 LMKL-PSDVVTAVRGKGLLNAIVIKETKDWDAWKVC----------LRLRDNGLLAKPTH 408 L +V + G++ +I + K A R N L+ + Sbjct: 363 WEALTDHPLVGEAKIVGMMASIALTPNKASRAKFASEPGTIGYICRERCFANNLIMRHV- 421 Query: 409 GDIIRFAPPLVIKEDELRESIEIINKTILS 438 GD + +PPLVI E+ E I K++ Sbjct: 422 GDRMIISPPLVITPAEIDEMFVRIRKSLDE 451 >3FCR-A nrPDB Length = 458 Score = 358 bits (918), Expect = 3e-99, Method: Composition-based stats. Identities = 110/450 (24%), Positives = 182/450 (40%), Gaps = 58/450 (12%) Query: 40 SDDIFEREYKYGAHNYHPLP-VALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIV 98 D+ F H ++ G+++ D +G K D + VN G+ +I Sbjct: 13 RDNFFHPSTHLAQHARGESANRVIKTASGVFIEDRDGTKLLDAFAGLYCVNVGYGRQEIA 72 Query: 99 NALKSQVDKLTLTSRAFYNNVLGEYEEYITKLF---------NYHKVLPMNTGVEAGETA 149 A+ Q +L A+Y++ +G E L N KV G +A ET Sbjct: 73 EAIADQAREL-----AYYHSYVGHGTEASITLAKMILDRAPKNMSKVYFGLGGSDANETN 127 Query: 150 CKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDI--I 207 KL W Y + K KI+ + G L S + + F + Sbjct: 128 VKLI--WYYNNILGRPEKKKIISRWRGYHGSGLVTGSLTGLELFHKKFDLPVEQVIHTEA 185 Query: 208 PY-------------------NDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMG 248 PY +L AL +AAF+ EPI G G+V P GY Sbjct: 186 PYYFRREDLNQTEEQFVAHCVAELEALIEREGADTIAAFIGEPILGTGGIVPPPAGYWEA 245 Query: 249 VRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDD 308 ++ + +H +L +ADE+ TG R G D+ + PDI+ + K L+ P+S + D Sbjct: 246 IQTVLNKHDILLVADEVVTGFGRLGTMFGSDHYGLEPDIITIAKGLTSAYAPLSGSIVSD 305 Query: 309 DIMLTIKPG-------EHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELM 361 + ++ G HG TY +P+G +A L++L+E NL NA ++G L + Sbjct: 306 KVWKVLEQGTDENGPIGHGWTYSAHPIGAAAGVANLKLLDELNLVSNAGEVGAYLNATMA 365 Query: 362 KL--PSDVVTAVRGKGLLNAIVIKETKDWD---------AWKVCLRLRDN-GLLAKPT-H 408 + V VRG+GLL A+ + +D ++ +L + ++A+ Sbjct: 366 EALSQHANVGDVRGEGLLCAVEFVKDRDSRTFFDAADKIGPQISAKLLEQDKIIARAMPQ 425 Query: 409 GDIIRFAPPLVIKEDELRESIEIINKTILS 438 GDI+ FAPP + E + +E + + + Sbjct: 426 GDILGFAPPFCLTRAEADQVVEGTLRAVKA 455 >3R4T-A nrPDB Length = 467 Score = 357 bits (917), Expect = 5e-99, Method: Composition-based stats. Identities = 126/455 (27%), Positives = 216/455 (47%), Gaps = 47/455 (10%) Query: 20 SSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYF 79 +S+ + + T+ + GP + + R LPV + R G + D +G + Sbjct: 24 ASLDQSRLLVTE--IPGPASLELNKRRAAAVSGGVGVTLPVFVVRAGGGIVEDADGNRLI 81 Query: 80 DFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYN----NVLGEYEEYITKLFNYHK 135 D S + G+ P++V+A++ QV++ T T + E IT + Sbjct: 82 DLGSGIAVTTIGNSAPRVVDAVRDQVEQFTHTCFMVTPYEQYVAVAEQLNRITPGSGEKR 141 Query: 136 VLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYD 195 + N+G EA E + K+AR K +V + GRT ++ + Y Sbjct: 142 TVLFNSGAEAVENSIKVARA--------HTRKQAVVAFDYAYHGRTNLTMALTAKSMPYK 193 Query: 196 -GFGPFMPGFDIIP----YND------------------LPALERALQDPNVAAFMVEPI 232 GFGPF P P Y D + +++ + N+AA ++EPI Sbjct: 194 SGFGPFAPEIYRAPVSYPYRDNLLDKDIATDGELAAERAINLIDKQIGAANLAAVIIEPI 253 Query: 233 QGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGK 292 GE G +VP G+L ++ C + V+FIADE+QTG ARTG A D+ENV PD+++ K Sbjct: 254 AGEGGFIVPADGFLPALQRWCRDNDVVFIADEVQTGFARTGAMFACDHENVEPDLIVTAK 313 Query: 293 ALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKL 352 ++ G +P+SAV +IM G T+GGNP+ C A+A +E +E + + E A ++ Sbjct: 314 GIADG-FPLSAVTGRAEIMDAPHTSGLGGTFGGNPVACAAALATIETIERDGMVERARQI 372 Query: 353 GIILRNELMKLPS--DVVTAVRGKGLLNAIVIKE--TKDWDAW---KVCLRLRDNGLLA- 404 ++ + L++L + D + VRG+G + A+ + + T + DA K+ G++ Sbjct: 373 ERLVMDRLLRLQAADDRLGDVRGRGAMIAMELVKSGTAEPDAALTQKLAAAAHAAGVIVL 432 Query: 405 -KPTHGDIIRFAPPLVIKEDELRESIEIINKTILS 438 G++IR PPL I ++ L E ++I+ + + Sbjct: 433 TCGMFGNVIRLLPPLTISDELLSEGLDILCQILAD 467 >3OKS-A nrPDB Length = 451 Score = 356 bits (915), Expect = 8e-99, Method: Composition-based stats. Identities = 134/451 (29%), Positives = 220/451 (48%), Gaps = 49/451 (10%) Query: 23 ASATSVATKKTVQGPPTSDDIFEREYKYGAHNY-HPLPVALERGKGIYLWDVEGRKYFDF 81 + +AT P S + +R+ A +PV R G + DV+G + D Sbjct: 10 EQSRHLATAIP---GPRSQALIDRKGTAVARGVGTTMPVYAVRAGGGIVEDVDGNRLIDL 66 Query: 82 LSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAF--YNNVLGEYEE--YITKLFNYHKVL 137 S + G+ PK+V A++SQV T T Y + E+ +T + + Sbjct: 67 GSGIAVTTVGNSAPKVVEAVRSQVGDFTHTCFMVTPYEGYVAVCEQLNRLTPVRGDKRSA 126 Query: 138 PMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSY-DG 196 N+G EA E A K+AR +K +V + GRT ++ + Y DG Sbjct: 127 LFNSGSEAVENAVKIARS--------HTHKPAVVAFDHAYHGRTNLTMALTAKVMPYKDG 178 Query: 197 FGPFMPGFDIIP----YNDLP------------------ALERALQDPNVAAFMVEPIQG 234 FGPF P P + D +++ + N+AA ++EPIQG Sbjct: 179 FGPFAPEIYRAPLSYPFRDAEFGKELATDGELAAKRAITVIDKQIGADNLAAVVIEPIQG 238 Query: 235 EAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKAL 294 E G +VP G+L + + C ++ V+FIADE+QTG ARTG A ++E + PD+++ K + Sbjct: 239 EGGFIVPADGFLPTLLDWCRKNDVVFIADEVQTGFARTGAMFACEHEGIDPDLIVTAKGI 298 Query: 295 SGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGI 354 +GGL P+SAV +IM + G TYGGNP+ C A+A +E +E E L A ++ Sbjct: 299 AGGL-PLSAVTGRAEIMDSPHVSGLGGTYGGNPIACAAALATIETIESEGLVARAQQIEK 357 Query: 355 ILRNELMKLPS--DVVTAVRGKGLLNAIVIKE--TKDWDA---WKVCLRLRDNGLLA--K 405 I+++ L +L + D + VRG+G + A+ + + T + DA +C G++ Sbjct: 358 IMKDRLGRLQAEDDRIGDVRGRGAMIAMELVKAGTTEPDADLTKALCAGAHAAGVIVLSC 417 Query: 406 PTHGDIIRFAPPLVIKEDELRESIEIINKTI 436 T+G+++RF PPL I +D L E ++++ + + Sbjct: 418 GTYGNVVRFLPPLSIGDDLLNEGLDVLEEVL 448 >1SFF-A nrPDB Length = 426 Score = 356 bits (915), Expect = 9e-99, Method: Composition-based stats. Identities = 120/432 (27%), Positives = 210/432 (48%), Gaps = 39/432 (9%) Query: 37 PPTSDDIFEREYKYGAHNYHPL-PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHP 95 ++ ++ +R + + P+ +R + +WDVEGR+Y DF + +N GH HP Sbjct: 1 MNSNKELMQRRSQAIPRGVGQIHPIFADRAENCRVWDVEGREYLDFAGGIAVLNTGHLHP 60 Query: 96 KIVNALKSQVDKLTLTS-RAFYNNVLGEYEEYITKLFNYH---KVLPMNTGVEAGETACK 151 K+V A+++Q+ KL+ T + E E + + K L + TG EA E A K Sbjct: 61 KVVAAVEAQLKKLSHTCFQVLAYEPYLELCEIMNQKVPGDFAKKTLLVTTGSEAVENAVK 120 Query: 152 LARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIP--- 208 +AR ++ + +G + GRT ++ + Y MPG Sbjct: 121 IARA--------ATKRSGTIAFSGAYHGRTHYTLALTGKVNPYSAGMGLMPGHVYRALYP 172 Query: 209 --------YNDLPALERAL----QDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRH 256 + + ++ R ++AA ++EP+QGE G P ++ +R LC H Sbjct: 173 CPLHGISEDDAIASIHRIFKNDAAPEDIAAIVIEPVQGEGGFYASSPAFMQRLRALCDEH 232 Query: 257 QVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKP 316 ++ IADE+Q+G RTG A++ V PD+ K+++GG +P++ V ++M + P Sbjct: 233 GIMLIADEVQSGAGRTGTLFAMEQMGVAPDLTTFAKSIAGG-FPLAGVTGRAEVMDAVAP 291 Query: 317 GEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLP--SDVVTAVRGK 374 G G TY GNP+ C A+ L+V E+ENL + A+ LG L++ L+ + + VRG Sbjct: 292 GGLGGTYAGNPIACVAALEVLKVFEQENLLQKANDLGQKLKDGLLAIAEKHPEIGDVRGL 351 Query: 375 GLLNAIVIKETKDWD------AWKVCLRLRDNGLLA--KPTHGDIIRFAPPLVIKEDELR 426 G + AI + E D + ++ R RD GL+ + +++R PL I++ ++R Sbjct: 352 GAMIAIELFEDGDHNKPDAKLTAEIVARARDKGLILLSCGPYYNVLRILVPLTIEDAQIR 411 Query: 427 ESIEIINKTILS 438 + +EII++ Sbjct: 412 QGLEIISQCFDE 423 >4E3Q-A nrPDB Length = 473 Score = 351 bits (900), Expect = 4e-97, Method: Composition-based stats. Identities = 101/441 (22%), Positives = 181/441 (41%), Gaps = 53/441 (12%) Query: 45 EREYKYGAHNYHPLP-------VALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKI 97 R Y + + +P V + G+G Y+ DV GR+Y D S + G H + Sbjct: 29 ARAETYSLYGFTDMPSLHQRGTVVVTHGEGPYIVDVNGRRYLDANSGLWNMVAGFDHKGL 88 Query: 98 VNALKSQVDKLTLTSRAF--YNNVLGEYEEYITKLFNYH--KVLPMNTGVEAGETACKLA 153 ++A K+Q ++ F ++ E + ++ + +V N+G EA +T K+ Sbjct: 89 IDAAKAQYERFPGYHAFFGRMSDQTVMLSEKLVEVSPFDSGRVFYTNSGSEANDTMVKM- 147 Query: 154 RKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDII--PY-- 209 W + K KI+ + G T + S + P FG +PGF + P+ Sbjct: 148 -LWFLHAAEGKPQKRKILTRWNAYHGVTAVSASMTGKP-YNSVFGLPLPGFVHLTCPHYW 205 Query: 210 -----------------NDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVREL 252 +L + +A F EP+ G GV+ P GY + + Sbjct: 206 RYGEEGETEEQFVARLARELEETIQREGADTIAGFFAEPVMGAGGVIPPAKGYFQAILPI 265 Query: 253 CTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDI-- 310 ++ + I+DE+ G RTG + PD ++ K L+ G +P+ AV+ ++ Sbjct: 266 LRKYDIPVISDEVICGFGRTGNTWGCVTYDFTPDAIISSKNLTAGFFPMGAVILGPELSK 325 Query: 311 -----MLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPS 365 + I+ HG T G+P+GC +A+ A++V+ E LAEN +L L + Sbjct: 326 RLETAIEAIEEFPHGFTASGHPVGCAIALKAIDVVMNEGLAENVRRLAPRFEERLKHIAE 385 Query: 366 D-VVTAVRGKGLLNAIVIKETKDWDAW---------KVCLRLRDNGLLAKPTHGDIIRFA 415 + RG G + A+ + K ++ D GL+ +P G + Sbjct: 386 RPNIGEYRGIGFMWALEAVKDKASKTPFDGNLSVSERIANTCTDLGLICRPL-GQSVVLC 444 Query: 416 PPLVIKEDELRESIEIINKTI 436 PP ++ E ++ E + + K + Sbjct: 445 PPFILTEAQMDEMFDKLEKAL 465 >6ERK-A nrPDB Length = 451 Score = 350 bits (897), Expect = 1e-96, Method: Composition-based stats. Identities = 117/434 (26%), Positives = 201/434 (46%), Gaps = 34/434 (7%) Query: 35 QGPPTSDDIFEREYKYGAHNYHPLP-----VALERGKGIYLWDVEGRKYFDFLSSYSAVN 89 QG T+ + + ++ H Y LP + ++R +GIY+ +G + D +SS+ A Sbjct: 18 QGHMTTVSTNDFDQQHLWHPYASLPPTYPNIVIDRAEGIYIVTEDGTRLIDGMSSWWASV 77 Query: 90 QGHCHPKIVNALKSQVDKLTLTSRA-FYNNVLGEYEEYITKLF--NYHKVLPMNTGVEAG 146 G+ HPK+ A+ Q+ K+ + + + + + + ++G A Sbjct: 78 HGYNHPKLNAAMIEQLGKMAHVMFGGLTHQPAIDLGKKLLSIVPAGLDAIFYADSGSIAV 137 Query: 147 ETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSS-TDPTSYDGFGPFMP--G 203 E A K+A ++ + + K + ++G T A+S + +G +P Sbjct: 138 EVALKMALQY--QIAAKRPSKCQFASTHSGYYGDTWHAMSVCDPINGMHSLYGKQLPMQH 195 Query: 204 FDIIP----YNDLPALERAL-------QDPNVAAFMVEPI-QGEAGVVVPDPGYLMGVRE 251 F P DL ER +A F++EPI QG G+ P YL +R+ Sbjct: 196 FVAAPPMGFERDLTQSEREALTEFFVKNSDKLAGFIIEPIIQGAGGMRFYSPQYLQLLRK 255 Query: 252 LCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIM 311 LC + VL IADEI TG R+G+ A ++ + PDI+ +GKAL+GG +A L +I Sbjct: 256 LCDEYDVLLIADEIATGFGRSGKLFACEHAAISPDIMTIGKALTGGYMTFAATLSTREIA 315 Query: 312 LTIKPGE-----HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPS- 365 TI + HG T+ GNPL C VA A+++++ ++ + + I+ +L S Sbjct: 316 DTISQSDYPALMHGPTFMGNPLACAVACASIDLIVSYDIEARTENMQAIMNEQLAPAVSL 375 Query: 366 DVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDEL 425 + V VR G + I + E D ++ L +NG+ +P G ++ PP VI +DEL Sbjct: 376 EGVKEVRCLGAVAVIELNEAVDMPIFQTL--LINNGIWVRP-FGKLVYIMPPYVITDDEL 432 Query: 426 RESIEIINKTILSF 439 + + K + S+ Sbjct: 433 TTLCQALLKVVSSY 446 >4GRX-A nrPDB Length = 465 Score = 350 bits (897), Expect = 1e-96, Method: Composition-based stats. Identities = 109/454 (24%), Positives = 186/454 (40%), Gaps = 53/454 (11%) Query: 32 KTVQGPPTSDDIFEREYKYGAHNYHPLP-------VALERGKGIYLWDVEGRKYFDFLSS 84 + +G R Y + + +P V + G+G Y+ DV GR+Y D S Sbjct: 8 QFEKGANQPQSWEARAETYSLYGFTDMPSVHQRGTVVVTHGEGPYIVDVHGRRYLDANSG 67 Query: 85 YSAVNQGHCHPKIVNALKSQVDKLTLTSRAF--YNNVLGEYEEYITKLFNYH--KVLPMN 140 + G H ++ A K+Q D+ F ++ E + ++ + +V N Sbjct: 68 LWNMVAGFDHKGLIEAAKAQYDRFPGYHAFFGRMSDQTVMLSEKLVEVSPFDNGRVFYTN 127 Query: 141 TGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPF 200 +G EA +T K+ W + K KI+ + G T + S + P FG Sbjct: 128 SGSEANDTMVKM--LWFLHAAEGKPQKRKILTRWNAYHGVTAVSASMTGKP-YNSVFGLP 184 Query: 201 MPGFDIIP------YND--------LPALERALQD-------PNVAAFMVEPIQGEAGVV 239 +PGF + Y + + L R L+D +A F EP+ G GV+ Sbjct: 185 LPGFIHLTCPHYWRYGEEGETEAQFVARLARELEDTITREGADTIAGFFAEPVMGAGGVI 244 Query: 240 VPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLY 299 P GY + + ++ + I+DE+ G RTG + PD ++ K L+ G + Sbjct: 245 PPAKGYFQAILPILRKYDIPMISDEVICGFGRTGNTWGCLTYDFMPDAIISSKNLTAGFF 304 Query: 300 PVSAVLCDDDIM-------LTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKL 352 P+ AV+ D+ I+ HG T G+P+GC +A+ A++V+ E LAEN +L Sbjct: 305 PMGAVILGPDLAKRVEAAVEAIEEFPHGFTASGHPVGCAIALKAIDVVMNEGLAENVRRL 364 Query: 353 GIILRNELMKLPSD-VVTAVRGKGLLNAIVIKETKDWDAW---------KVCLRLRDNGL 402 L ++ + RG G + A+ + K ++ D GL Sbjct: 365 APRFEAGLKRIADRPNIGEYRGIGFMWALEAVKDKPTKTPFDANLSVSERIANTCTDLGL 424 Query: 403 LAKPTHGDIIRFAPPLVIKEDELRESIEIINKTI 436 + +P G I PP ++ E ++ E E + K + Sbjct: 425 ICRPL-GQSIVLCPPFILTEAQMDEMFEKLEKAL 457 >5UC7-A nrPDB Length = 431 Score = 340 bits (873), Expect = 6e-94, Method: Composition-based stats. Identities = 125/436 (28%), Positives = 200/436 (45%), Gaps = 46/436 (10%) Query: 37 PPTSDDIFEREYKYGAHNY----HPLPVA-LERGKGIYLWDVEGRKYFDFLSSYSAVNQG 91 T+DD+ + ++ H Y PLPV +ER +G L G + D +SS+ A G Sbjct: 2 GMTTDDL-AFDRRHIWHPYTSMTSPLPVFPVERAEGCELILSGGERLVDGMSSWWAAIHG 60 Query: 92 HCHPKIVNALKSQVDKLTLTSRA-FYNNVLGEYEEYITKLFN--YHKVLPMNTGVEAGET 148 + HP++ A+K+Q+D ++ + E + + V ++G A E Sbjct: 61 YNHPQLNAAMKTQIDAMSHVMFGGITHAPAIELCRKLVAMTPAPLECVFLADSGSVAVEV 120 Query: 149 ACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTS--------YDGFGPF 200 A K+A ++ + KG + + + + + G T A+S DP + Y F Sbjct: 121 AMKMALQY-WQAKG--ESRQRFLTFRNGYHGDTFGAMSVC-DPHNSMHSLWKGYLAENLF 176 Query: 201 MPGF-----------DIIPYNDLPALERALQDPNVAAFMVEPI-QGEAGVVVPDPGYLMG 248 P D++ + L A R +AA ++EPI QG G+ + P +L Sbjct: 177 APAPQSRMGGEWDERDMVAFARLMAAHR----HEIAAVILEPIVQGAGGMRIYHPQWLQR 232 Query: 249 VRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDD 308 +R++C R +L IADEI TG RTGR A ++ + PDI+ LGKAL+GG +SA L Sbjct: 233 IRQMCDREGILLIADEIATGFGRTGRLFACEHAGIAPDILCLGKALTGGTMTLSATLTSR 292 Query: 309 DIMLTIKPGE-----HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKL 363 + TI GE HG T+ GNPL C VA A+L +LE + + LR EL Sbjct: 293 QVAETISNGEAGCFMHGPTFMGNPLACAVANASLTLLESGDWRRQVAAIEAQLREELAPA 352 Query: 364 P-SDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKE 422 S V VR G + + T+ + + G+ +P G +I PP +I+ Sbjct: 353 ADSPQVADVRVLGAIGVVE--TTRPVNIAALQQFFVRQGVWVRP-FGKLIYLMPPYIIQP 409 Query: 423 DELRESIEIINKTILS 438 ++LR + +N+ + Sbjct: 410 EQLRRLTQAVNEAVRE 425 >3A8U-X nrPDB Length = 449 Score = 340 bits (872), Expect = 9e-94, Method: Composition-based stats. Identities = 116/427 (27%), Positives = 185/427 (43%), Gaps = 43/427 (10%) Query: 49 KYGAH-NYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDK 107 Y A+ N+ P + +G +L D +GRK +D LS GH +I A+ Q+ Sbjct: 22 PYTANRNFLRDPRLIVAAEGSWLVDDKGRKVYDSLSGLWTCGAGHTRKEIQEAVAKQLST 81 Query: 108 LTLTSRAFYNNVLG-EYEEYITKLF--NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQ 164 L + Y + L + E IT L N + V ++G E TA K+ R + Q Sbjct: 82 LDYSPGFQYGHPLSFQLAEKITDLTPGNLNHVFFTDSGSECALTAVKMVRAYWRL--KGQ 139 Query: 165 KYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPY--------------- 209 K K++ A + G ++ S + FG M D +P+ Sbjct: 140 ATKTKMIGRARGYHGVNIAGTSLGGVNGNRKLFGQPMQDVDHLPHTLLASNAYSRGMPKE 199 Query: 210 ------NDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIAD 263 ++L L N+AA VEP+ G AGV+VP GYL RE+C +H +L + D Sbjct: 200 GGIALADELLKLIELHDASNIAAVFVEPLAGSAGVLVPPEGYLKRNREICNQHNILLVFD 259 Query: 264 EIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIK-------- 315 E+ TG RTG D V PD++ + K ++ G P+ AV+ +I T Sbjct: 260 EVITGFGRTGSMFGADSFGVTPDLMCIAKQVTNGAIPMGAVIASTEIYQTFMNQPTPEYA 319 Query: 316 -PGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLP-SDVVTAVRG 373 HG TY +P+ C +AAL +L++ENL ++ ++ L + + V +R Sbjct: 320 VEFPHGYTYSAHPVACAAGLAALCLLQKENLVQSVAEVAPHFEKALHGIKGAKNVIDIRN 379 Query: 374 KGLLNAIVIKETKDWDA----WKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESI 429 GL AI I +D DA ++ + L G + GD ++F P K +L Sbjct: 380 FGLAGAIQI-APRDGDAIVRPFEAGMALWKAGFYVR-FGGDTLQFGPTFNSKPQDLDRLF 437 Query: 430 EIINKTI 436 + + + + Sbjct: 438 DAVGEVL 444 >4PPM-A nrPDB Length = 861 Score = 334 bits (856), Expect = 6e-92, Method: Composition-based stats. Identities = 125/461 (27%), Positives = 200/461 (43%), Gaps = 74/461 (16%) Query: 38 PTSDDIFEREYKYGAHNYHPL------PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQG 91 P +D +R ++Y G L+D G + D ++ Y +N G Sbjct: 389 PAREDTLDRYHQYINPMMVDFLKLQRCDNVFRSAAGTQLYDDAGEAFLDMVAGYGCLNLG 448 Query: 92 HCHPKIVNALKSQVDKLTLTSRAFYN--NVLGEYEEYITKLF--NYHKVLPMNTGVEAGE 147 H +VNALK+ +D + + + E + +L N +V N+G EA E Sbjct: 449 HNPQPVVNALKNYLDAQGPNFIQYISIPEQTAKLAEVLCRLAPGNMGRVFFSNSGTEAVE 508 Query: 148 TACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDII 207 A K+A+ K I + ++ G+TL A+S + F P + + Sbjct: 509 AAMKIAKA--------STGKPGIAYLRNSYHGKTLGALSITGRDKHRRYFTPLLDAMVEV 560 Query: 208 PYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQT 267 P+ DL AL AL +V A M+EPIQGE GV +P GYL V++LC VL + DE+QT Sbjct: 561 PFGDLAALREALNREDVGALMIEPIQGEGGVHIPPAGYLQAVQQLCRETGVLLMVDEVQT 620 Query: 268 GLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE-----HGST 322 GL RTG+ A +++ + PD+++L K+LSGGL P+ A LC D+ H ST Sbjct: 621 GLGRTGKLFACEWDGIEPDVLMLSKSLSGGLIPIGATLCRADLWQKAYGTADRFLVHSST 680 Query: 323 YGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSD--VVTAVRGKGLLNAI 380 YGG L VA++AL + ++L +A+++G + L ++ + V+ VRG+GL+ I Sbjct: 681 YGGGNLASVVALSALREILAQDLVGHAERMGAYFKQALSEIAARYPFVSEVRGRGLMLGI 740 Query: 381 VIKE----TKDWDAWKVCLR---------------------------------------- 396 + + A + R Sbjct: 741 QFDQAFTGAVNASAREFATRLPGDWHTTWKFLPDPVQAHLRAAMDRMEQALGEMFCMKFV 800 Query: 397 ---LRDNGLLAKPTHGD--IIRFAPPLVIKEDELRESIEII 432 +D+ +L T +IR PPL+I + E+ + Sbjct: 801 TKLCQDHKILTFITANSSTVIRIQPPLIISKAEIDRFVGAF 841 >3I5T-A nrPDB Length = 476 Score = 333 bits (854), Expect = 1e-91, Method: Composition-based stats. Identities = 94/445 (21%), Positives = 170/445 (38%), Gaps = 44/445 (9%) Query: 34 VQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHC 93 G D I + P L +GIY+ +GR+ D + G+ Sbjct: 13 AVGAAMRDHILLPAQEMAKLGKSAQP-VLTHAEGIYVHTEDGRRLIDGPAGMWCAQVGYG 71 Query: 94 HPKIVNALKSQVDKLTLTSRAFY-NNVLGEYEEYITKLF--NYHKVLPMNTGVEAGETAC 150 +IV+A+ Q L S + + E I L + +++ G A ++A Sbjct: 72 RREIVDAMAHQAMVLPYASPWYMATSPAARLAEKIATLTPGDLNRIFFTTGGSTAVDSAL 131 Query: 151 KLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYN 210 + Y + K +I+ + G T + + ++ F + Sbjct: 132 R--FSEFYNNVLGRPQKKRIIVRYDGYHGSTALTAACTGRTGNWPNFDIAQDRISFLSSP 189 Query: 211 -------------------DLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRE 251 + +L +AAF+ EPI GV++P GY + Sbjct: 190 NPRHAGNRSQEAFLDDLVQEFEDRIESLGPDTIAAFLAEPILASGGVIIPPAGYHARFKA 249 Query: 252 LCTRHQVLFIADEIQTGLARTGRWLAVDY-ENVRPDIVLLGKALSGGLYPVSAVLCDDDI 310 +C +H +L+I+DE+ TG R G W A + V PDI+ K ++ G P+ + + + Sbjct: 250 ICEKHDILYISDEVVTGFGRCGEWFASEKVFGVVPDIITFAKGVTSGYVPLGGLAISEAV 309 Query: 311 MLTIKP-------GEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKL 363 + I +G TY P+ C A+A +E++E E + + A ++ L L Sbjct: 310 LARISGENAKGSWFTNGYTYSNQPVACAAALANIELMEREGIVDQAREMADYFAAALASL 369 Query: 364 PS-DVVTAVRGKGLLNAIV--IKETKDWDAW-------KVCLRLRDNGLLAKPTHGDIIR 413 V R GL+ + + T+ K+ R + GL+ +P GD+ Sbjct: 370 RDLPGVAETRSVGLVGCVQCLLDPTRADGTAEDKAFTLKIDERCFELGLIVRPL-GDLCV 428 Query: 414 FAPPLVIKEDELRESIEIINKTILS 438 +PPL+I ++ E + I+ + I Sbjct: 429 ISPPLIISRAQIDEMVAIMRQAITE 453 >3Q8N-A nrPDB Length = 453 Score = 330 bits (847), Expect = 6e-91, Method: Composition-based stats. Identities = 132/437 (30%), Positives = 211/437 (48%), Gaps = 39/437 (8%) Query: 32 KTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQG 91 + GP + + ++ A LPV + G L D +G + DF S + G Sbjct: 24 TAIPGPISQELQARKQSAVAAGVGVTLPVYVVAAGGGVLADADGNQLIDFGSGIAVTTVG 83 Query: 92 HCHPKIVNALKSQVDKLTLTS---RAFYNNV-LGEYEEYITKLFNYHKVLPMNTGVEAGE 147 + P +V+A+ QV T T + V + E+ +T + + N+G EA E Sbjct: 84 NSAPAVVDAVTQQVAAFTHTCFMVTPYEGYVKVAEHLNRLTPGDHEKRTALFNSGAEAVE 143 Query: 148 TACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYD-GFGPFMPGFDI 206 A K+AR + + +V + GRT ++ + Y GFGPF Sbjct: 144 NAVKIARAY--------TRRQAVVVFDHAYHGRTNLTMAMTAKNQPYKHGFGPFANEVYR 195 Query: 207 IP----YND------------LPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVR 250 +P + D L + + + NVAA ++EP+ GE G VVP PG+L ++ Sbjct: 196 VPTSYPFRDGETDGAAAAAHALDLINKQVGADNVAAVVIEPVHGEGGFVVPAPGFLGALQ 255 Query: 251 ELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDI 310 + CT + +F+ADE+QTG ARTG A ++ENV PD+++ K ++GGL P+SAV +I Sbjct: 256 KWCTDNGAVFVADEVQTGFARTGALFACEHENVVPDLIVTAKGIAGGL-PLSAVTGRAEI 314 Query: 311 MLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPS--DVV 368 M + G G TYGGNPL C A+A ++ +E ENL A +G + + L L + + Sbjct: 315 MDGPQSGGLGGTYGGNPLACAAALAVIDTIERENLVARARAIGETMLSRLGALAAADPRI 374 Query: 369 TAVRGKGLLNAIVIKE--TKDWDA---WKVCLRLRDNGL--LAKPTHGDIIRFAPPLVIK 421 VRG+G + A+ + + T + DA +V GL L T+G+++RF PPL + Sbjct: 375 GEVRGRGAMIAVELVKPGTTEPDADLTKRVAAAAHAQGLVVLTCGTYGNVLRFLPPLSMP 434 Query: 422 EDELRESIEIINKTILS 438 + L E ++I+ Sbjct: 435 DHLLDEGLDILAAVFAE 451 >1S09-A nrPDB Length = 429 Score = 326 bits (836), Expect = 1e-89, Method: Composition-based stats. Identities = 117/430 (27%), Positives = 200/430 (46%), Gaps = 36/430 (8%) Query: 38 PTSDDIFEREYKYGAHNY----HPLPVA-LERGKGIYLWDVEGRKYFDFLSSYSAVNQGH 92 T+DD+ + ++ H Y PLPV + +G L +GR+ D +SS+ A G+ Sbjct: 1 MTTDDL-AFDQRHILHPYTSMTSPLPVYPVVSAEGCELILSDGRRLVDGMSSWWAAIHGY 59 Query: 93 CHPKIVNALKSQVDKLTLTSRAFYNNVLG-EYEEYITKLFN--YHKVLPMNTGVEAGETA 149 HP++ A+KSQ+D ++ + E + + V ++G A E A Sbjct: 60 NHPQLNAAMKSQIDAMSHVMFGGITHAPAIELCRKLVAMTPQPLECVFLADSGSVAVEVA 119 Query: 150 CKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSS-TDPTSYDGFGPFMPGFDIIP 208 K+A ++ + KG + + + + F G T A+S D + + + ++P P Sbjct: 120 MKMALQY-WQAKG--EARQRFLTFRNGFHGDTFGAMSVCDPDNSMHSLWKGYLPENLFAP 176 Query: 209 -----------YNDLPALERALQDP--NVAAFMVEPI-QGEAGVVVPDPGYLMGVRELCT 254 D+ R + +AA ++EPI QG G+ + P +L +R++C Sbjct: 177 APQSRMDGEWDERDMVGFARLMAAHRHEIAAVIIEPIVQGAGGMRMYHPEWLKRIRKICD 236 Query: 255 RHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTI 314 R +L IADEI TG RTG+ A ++ + PDI+ LGKAL+GG +SA L ++ TI Sbjct: 237 REGILLIADEIATGFGRTGKLFACEHAEIAPDILCLGKALTGGTMTLSATLTTREVAETI 296 Query: 315 KPGE-----HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKL-PSDVV 368 GE HG T+ GNPL C A A+L +LE + + + + LR +L +++V Sbjct: 297 SNGEAGCFMHGPTFMGNPLACAAANASLAILESGDWQQQVADIEVQLREQLAPARDAEMV 356 Query: 369 TAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRES 428 VR G + + T + + + G+ +P G +I PP +I +L+ Sbjct: 357 ADVRVLGAIGVVE--TTHPVNMAALQKFFVEQGVWIRP-FGKLIYLMPPYIILPQQLQRL 413 Query: 429 IEIINKTILS 438 +N+ + Sbjct: 414 TAAVNRAVQD 423 >5M46-A nrPDB Length = 440 Score = 312 bits (800), Expect = 2e-85, Method: Composition-based stats. Identities = 110/437 (25%), Positives = 199/437 (45%), Gaps = 45/437 (10%) Query: 35 QGPPTSDDIFEREYKY--GAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGH 92 QGP + +++ R+ P+A+ G+G L + +GR+ D ++ A + G+ Sbjct: 1 QGPAMAGNLYGRDGAAIGSLQKLRFFPLAVAGGQGARLVEEDGRELIDLSGAWGAASLGY 60 Query: 93 CHPKIVNALKSQVDKLTLTSRAFYNNVLG-EYEEYITKLF---NYHKVLPMNTGVEAGET 148 HP I+ A+ S +N E +T F HKV ++G +A E Sbjct: 61 GHPAIIEAVSRAAANPAGASILSASNAPAVALAERLTASFPGRGTHKVWFGHSGSDANEA 120 Query: 149 ACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIP 208 A + + + ++ G + G T+ +++ S D G ++P Sbjct: 121 AYRAITR--------ATGRTGVIAFIGAYHGCTVGSMAFSGHSVQADAAK--ADGLILLP 170 Query: 209 YND--------------LPALER---ALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRE 251 Y D L L+ A+ ++AA +EPIQ + G++VP G+L + Sbjct: 171 YPDPYRPYQDDPTGDAVLALLKERLAAVPAGSIAAAFIEPIQSDGGLIVPPDGFLRKFAD 230 Query: 252 LCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIM 311 +C H + + DE++ GLAR+GR ++E PDI++LG GG P+SAV+ +I+ Sbjct: 231 ICRAHGISVVCDEVKVGLARSGRLHCFEHEGFVPDILVLG-KGLGGGLPLSAVIAPAEIL 289 Query: 312 LTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLP--SDVVT 369 T GNP+ +A LE +E ENL A++ G +LR L +L +++ Sbjct: 290 D-CASAFAMQTLHGNPVCAAAGLAVLETIEAENLTTAAERKGKLLREGLARLAERHELIG 348 Query: 370 AVRGKGLLNAIVI------KETKDWDAWKVCLRLRDNGLLAK--PTHGDIIRFAPPLVIK 421 +RG+GL + + +E + K+ R + GL+ +G+++ PPL + Sbjct: 349 DIRGRGLACGVELVRNRQSREPARAETAKLIYRAYELGLVLYYVGMNGNVLEMTPPLTMT 408 Query: 422 EDELRESIEIINKTILS 438 EDE+R ++ ++++ Sbjct: 409 EDEVRHAVNLLDQAFTE 425 >1ZOD-A nrPDB Length = 433 Score = 312 bits (799), Expect = 3e-85, Method: Composition-based stats. Identities = 121/437 (27%), Positives = 193/437 (44%), Gaps = 48/437 (10%) Query: 39 TSDDIFEREYKYGAHNY--HPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPK 96 D F R ++ Y P+ +ER KG +++D +GR DF S + GHCHP+ Sbjct: 4 NDDATFWRNARHHLVRYGGTFEPMIIERAKGSFVYDADGRAILDFTSGQMSAVLGHCHPE 63 Query: 97 IVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLF--NYHKVLPMNTGVEAGETACKLAR 154 IV+ + KL + + + + + + L ++TG E+ E A ++A+ Sbjct: 64 IVSVIGEYAGKLDHLFSEMLSRPVVDLATRLANITPPGLDRALLLSTGAESNEAAIRMAK 123 Query: 155 KWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIP------ 208 + K +IV A ++ G T +A S++ G GP G IP Sbjct: 124 --------LVTGKYEIVGFAQSWHGMTGAAASATYSAG-RKGVGPAAVGSFAIPAPFTYR 174 Query: 209 --------YNDLPALERALQ------DPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCT 254 Y+ L L+ A N+AAF+ EPI G++ GY+ ++ C Sbjct: 175 PRFERNGAYDYLAELDYAFDLIDRQSSGNLAAFIAEPILSSGGIIELPDGYMAALKRKCE 234 Query: 255 RHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTI 314 +L I DE QTG+ RTG A + V PDI+ L K L GL P++A++ I Sbjct: 235 ARGMLLILDEAQTGVGRTGTMFACQRDGVTPDILTLSKTLGAGL-PLAAIVTSAAIEERA 293 Query: 315 KPGEHGS--TYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPS--DVVTA 370 + T+ +PL V + L+V++ + L A+ +G LR L+ L D + Sbjct: 294 HELGYLFYTTHVSDPLPAAVGLRVLDVVQRDGLVARANVMGDRLRRGLLDLMERFDCIGD 353 Query: 371 VRGKGLLNAIVI------KETKDWDAWKVCLRLRDNGL----LAKPTHGDIIRFAPPLVI 420 VRG+GLL + I KE D K+ + GL + P G + R APPL + Sbjct: 354 VRGRGLLLGVEIVKDRRTKEPADGLGAKITRECMNLGLSMNIVQLPGMGGVFRIAPPLTV 413 Query: 421 KEDELRESIEIINKTIL 437 EDE+ + ++ + I Sbjct: 414 SEDEIDLGLSLLGQAIE 430 >4FFC-A nrPDB Length = 453 Score = 310 bits (795), Expect = 7e-85, Method: Composition-based stats. Identities = 134/454 (29%), Positives = 205/454 (45%), Gaps = 44/454 (9%) Query: 20 SSVASATSVATKKTVQGP---PTSDDIFEREYK-YGAHNYHPLPVALERGKGIYLWDVEG 75 S +A K+T+ P P S + ER A PV G + D +G Sbjct: 4 SMTDITYRLAQKRTIVTPLPGPRSGALAERRRAAVSAGVGSTAPVYAVDADGGVIVDADG 63 Query: 76 RKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRA-FYNNVLGEYEEYITKLFNYH 134 + D + + G HP + A+ Q T T + E + L Sbjct: 64 NSFIDLGAGIAVTTVGASHPAVAAAIADQATHFTHTCFMVTPYEQYVQVAELLNALTPGD 123 Query: 135 ---KVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDP 191 + N+G EA E A K+AR + + +V + GRT ++ + Sbjct: 124 HDKRTALFNSGAEAVENAIKVAR--------LATGRPAVVAFDNAYHGRTNLTMALTAKS 175 Query: 192 TSYDG-FGPFMPGFDIIPYND-----------------LPALERALQDPNVAAFMVEPIQ 233 Y FGPF P +P + + +E + ++AA ++EPIQ Sbjct: 176 MPYKSQFGPFAPEVYRMPASYPLRDEPGLTGEEAARRAISRIETQIGAQSLAAIIIEPIQ 235 Query: 234 GEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKA 293 GE G +VP PG+L + + + V+FIADE+QTG ARTG W A ++E + PDIV + K Sbjct: 236 GEGGFIVPAPGFLATLTAWASENGVVFIADEVQTGFARTGAWFASEHEGIVPDIVTMAKG 295 Query: 294 LSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLG 353 ++GG+ P+SAV ++M + G G TYGGNP+ C A+AAL V+ E +L A + Sbjct: 296 IAGGM-PLSAVTGRAELMDAVYAGGLGGTYGGNPVTCAAAVAALGVMRELDLPARARAIE 354 Query: 354 IILRNELMKLPS--DVVTAVRGKGLLNAIVIKE--TKDWDAW---KVCLRLRDNGL--LA 404 + + L L D++ VRG+G + AI I + T + DA + G+ L Sbjct: 355 ASVTSRLSALAEEVDIIGEVRGRGAMLAIEIVKPGTLEPDAALTKSIAAEALSQGVLILT 414 Query: 405 KPTHGDIIRFAPPLVIKEDELRESIEIINKTILS 438 T G++IR PPLVI +D L E I ++ I + Sbjct: 415 CGTFGNVIRLLPPLVIGDDLLDEGITALSDIIRA 448 >5G4J-A nrPDB Length = 446 Score = 310 bits (794), Expect = 1e-84, Method: Composition-based stats. Identities = 116/450 (25%), Positives = 207/450 (46%), Gaps = 51/450 (11%) Query: 26 TSVATKKTVQGPPTSDDIFEREYK-YGAHN--YHPLPVALERGKGIYLWDVEGRKYFDFL 82 TS T + P T++D+ R Y G H+ ++ P+ L G G++L D +G+ Y D Sbjct: 2 TSETTTTPSRVPQTANDLLARRYATIGPHSPLFYRQPLELVSGSGVWLTDAQGKVYLDGY 61 Query: 83 SSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFN--YHKVLPMN 140 ++ V GH +P + +A+ Q+ + L +R + N+ + EY E + F+ ++ N Sbjct: 62 NNVPHV--GHANPAVADAIYQQLLTVNLHTR-YLNSRVVEYAEALLSKFDGALERLFLTN 118 Query: 141 TGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPF 200 +G EA E A ++AR+ ++ + ++ G T S +T T ++ G Sbjct: 119 SGSEANELALRIARQ--------HTGNTGVLVSDFSYHGNTTSLAEITTGLTVHEPLGAH 170 Query: 201 M-----PGFDIIPYNDLP-ALERALQDPN------------VAAFMVEPIQGEAGVVVPD 242 + P I D+P LE++L D + V+ F+ +P+ G++ Sbjct: 171 VRALRIPDVSGIAEVDVPVLLEQSLADVDAAIASLQAAGHGVSVFLFDPLFSTEGLLQLP 230 Query: 243 PGYLMGVRELCTRHQVLFIADEIQTGLARTGR-WLAVDYENVRPDIVLLGKALSGGLYPV 301 GY+ GV L I+DE+Q+G RTG NV P++V +GK + G +P+ Sbjct: 231 SGYIEGVATRVRAAGGLVISDEVQSGFGRTGSGMWGYQMFNVEPELVTMGKPMGNG-HPI 289 Query: 302 SAVLCDDDIMLTIKPGEHG---STYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRN 358 AV+ +++ G H +T+ GNP+ +A L +++E+L AD+LG +R Sbjct: 290 GAVVTTAELLDEF--GRHNMFFNTFAGNPVSSAAGLAVLRYMDQEDLMAKADQLGKYIRK 347 Query: 359 ELMKLPSD--VVTAVRGKGLLNAIVIKETKDWDAWKVCLR------LRDNGLLAK--PTH 408 L + V +VRG+GL I I E+ L +R+ G+L H Sbjct: 348 RLENIAQRSGNVGSVRGRGLFFGIDIIESDGSRNPAPALTKILIEDMRERGVLISRVGPH 407 Query: 409 GDIIRFAPPLVIKEDELRESIEIINKTILS 438 ++++ PPLV + + + ++ S Sbjct: 408 DNVLKMRPPLVFGREHADILLGQLELSLAS 437 >5G0A-A nrPDB Length = 483 Score = 308 bits (790), Expect = 2e-84, Method: Composition-based stats. Identities = 104/464 (22%), Positives = 179/464 (38%), Gaps = 77/464 (16%) Query: 41 DDIFEREYKYGAHNYHPL----PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPK 96 + + E + KY + PV +E +G YL +G + DF + VN G + K Sbjct: 11 EQVKEWDRKYLMRTFSTQNEYQPVPIESTEGDYLIMPDGTRLLDFFNQLYCVNLGQKNQK 70 Query: 97 IVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYH-----KVLPMNTGVEAGETACK 151 + A+K +D+ + + + + I + KV ++TG EA ETA Sbjct: 71 VNAAIKEALDRYGFVWDTYATDYKAKAAKIIIEDILGDEDWPGKVRFVSTGSEAVETALN 130 Query: 152 LARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSA--------------------ISSSTDP 191 +AR + + +V ++ G T A S+ Sbjct: 131 IARLY--------TNRPLVVTREHDYHGWTGGAATVTRLRSYRSGLVGENSESFSAQIPG 182 Query: 192 TSYDGFGPFMPGFDIIPYNDLPALE----------------RALQDPNVAAFMVEPIQGE 235 +SY+ P ++ +D L+ VAA + E QG Sbjct: 183 SSYNSAVLMAPSPNMFQDSDGNLLKDENGELLSVKYTRRMIENYGPEQVAAVITEVSQGA 242 Query: 236 AGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALS 295 G +P Y+ +R++ VL+I DE+ TG RTG+W + V+PDI+ +GK LS Sbjct: 243 -GSAMPPYEYIPQIRKMTKELGVLWINDEVLTGFGRTGKWFGYQHYGVQPDIITMGKGLS 301 Query: 296 GGLYPVSAVLCDDDI--MLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLG 353 P AVL +I + E STY G+P+ A LEV+ EEN E A G Sbjct: 302 SSSLPAGAVLVSKEIAAFMDKHRWESVSTYAGHPVAMAAVCANLEVMMEENFVEQAKDSG 361 Query: 354 IILRN--ELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWK------------------- 392 +R+ EL++ + G GLL + I K + Sbjct: 362 EYIRSKLELLQEKHKSIGNFDGYGLLWIVDIVNAKTKTPYVKLDRNFTHGMNPNQIPTQI 421 Query: 393 VCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTI 436 + + + G+L + +R L + ++ ++++ ++ + Sbjct: 422 IMKKALEKGVLIGGVMPNTMRIGASLNVSRGDIDKAMDALDYAL 465 >4ATP-A nrPDB Length = 456 Score = 306 bits (784), Expect = 1e-83, Method: Composition-based stats. Identities = 129/468 (27%), Positives = 219/468 (46%), Gaps = 60/468 (12%) Query: 17 GVHSSVASATSVATKKTVQG---PPTSDDIFEREYKYGAHNYHP-LPVALERGKGIYLWD 72 ++ + + K+ + G P S + ER A +PV +E G + D Sbjct: 1 MTTTANELSYRIEQKRNINGAFPGPKSQALAERRSAVVAAGVASGVPVYVEDADGGIIRD 60 Query: 73 VEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFN 132 V+G + D S + + G P +V A++ T T ++ YE Y+ Sbjct: 61 VDGNSFIDLGSGIAVTSVGASDPAVVAAVQEAAAHFTHTCF-----MVTPYEGYVAVTEQ 115 Query: 133 YHKVLPM---------NTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLS 183 +++ P N+G EA E A K+AR + + +V + GRT Sbjct: 116 LNRLTPGDHAKRTVLFNSGAEAVENAVKVAR--------LATGRDAVVAFDHAYHGRTNL 167 Query: 184 AISSSTDPTSYD-GFGPFMPGFDIIPYND------------------LPALERALQDPNV 224 ++ + Y FGPF P +P + + +E+ + V Sbjct: 168 TMALTAKAMPYKTNFGPFAPEVYRMPMSYPFREENPEITGAEAAKRAITMIEKQIGGDQV 227 Query: 225 AAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVR 284 AA ++EPIQGE G +VP G+L + E ++FIADE+Q+G RTG W AVD+E V Sbjct: 228 AAIIIEPIQGEGGFIVPAEGFLPALSEWAKEKGIVFIADEVQSGFCRTGEWFAVDHEGVV 287 Query: 285 PDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEEN 344 PDI+ + K ++GGL P+SA+ D++ + PG G TYGGNP+ C A+AA++ +E+ + Sbjct: 288 PDIITMAKGIAGGL-PLSAITGRADLLDAVHPGGLGGTYGGNPVACAAALAAIDTMEQHD 346 Query: 345 LAENADKLGIILRNELMKLPSDV-------VTAVRGKGLLNAIVIKET--KDWDA---WK 392 L A + + +L +L +++ V +RG+G + AI + + K+ +A Sbjct: 347 LNGRARHIEELALGKLRELAAELSAGGGSVVGDIRGRGAMLAIELVQPGSKEPNAELTKA 406 Query: 393 VCLRLRDNGLL--AKPTHGDIIRFAPPLVIKEDELRESIEIINKTILS 438 V G++ T+G++IR PPLVI ++ L + +E++ I + Sbjct: 407 VAAACLKEGVIILTCGTYGNVIRLLPPLVISDELLIDGLEVLAAAIKA 454 >2CFB-A nrPDB Length = 411 Score = 303 bits (775), Expect = 1e-82, Method: Composition-based stats. Identities = 102/404 (25%), Positives = 165/404 (40%), Gaps = 38/404 (9%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLT-LTSRAFYN 117 P+ + KG ++WDV+G +Y D++ S+ GH HP++++AL + ++K T + Sbjct: 19 PIVFDHVKGAHIWDVDGNQYIDYVGSWGPAIVGHAHPEVIDALHAALEKGTSFGAPCLLE 78 Query: 118 NVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNF 177 N+L E I + + V +N+G EA +L R + + K++ G + Sbjct: 79 NILAEMV--IAAVPSVEMVRFVNSGTEACMAVLRLMRAY--------TQREKVIKFEGCY 128 Query: 178 WGRTLSAISSSTDPTSYDGFGPFMPGFD--------IIPYNDLPALERALQ--DPNVAAF 227 G + + + G P PG PYNDL A+ R + ++A Sbjct: 129 HGHADMFLVKAGSGVATLGL-PDSPGVPKATTAATLTAPYNDLEAVSRLFEQYPNDIAGV 187 Query: 228 MVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDI 287 ++EP+ G AG + PD G+L G+REL ++ L + DE+ TG R A + V PD+ Sbjct: 188 ILEPVVGNAGFIPPDAGFLEGLRELTKQYGALLVFDEVMTGF-RIAYGGAQEKFGVTPDL 246 Query: 288 VLLGKALSGGLYPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAALEVLEEEN 344 LGK + GGL PV A +IM + P T GNPL I LE+L Sbjct: 247 TTLGKVIGGGL-PVGAYGGRAEIMKMVAPAGPVYQAGTLSGNPLAMTAGIKTLEILSRPG 305 Query: 345 LAENADKLGIILRNELMKLPSDVVTAVRG---KGLLNAIVIKETKDWDAWKVCLRLRDNG 401 E+ D++ L L+ + V G G+ L+ Sbjct: 306 SYEHLDRITGKLVQGLLDAAREFGHEVCGGHISGMFGLFFTAGPVTNYEQAKQSDLKKFA 365 Query: 402 LLAKPTHGDIIRFAP--------PLVIKEDELRESIEIINKTIL 437 + I AP L E ++ +I + Sbjct: 366 AFHRGMLEQGIYLAPSQFEAGFTSLAHTEADIERTIAAARTVLS 409 >4WYG-A nrPDB Length = 457 Score = 301 bits (771), Expect = 4e-82, Method: Composition-based stats. Identities = 109/429 (25%), Positives = 181/429 (42%), Gaps = 34/429 (7%) Query: 36 GPPTSDDIFEREYKYGAHNYHPLPV------ALERGKGIYLWDV-EGR--KYFDFLSSYS 86 G T + I + + H Y + G +L + +G+ + D +SS+ Sbjct: 26 GGLTPEQIIAVDGAHLWHPYSSIGREAVSPVVAVAAHGAWLTLIRDGQPIEVLDAMSSWW 85 Query: 87 AVNQGHCHPKIVNALKSQVDKLTLTSRA-FYNNVLGEYEEYITKLF--NYHKVLPMNTGV 143 GH HP + AL +Q+ + + + + + V ++G Sbjct: 86 TAIHGHGHPALDQALTTQLRVMNHVMFGGLTHEPAARLAKLLVDITPAGLDTVFFSDSGS 145 Query: 144 EAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSS----------TDPTS 193 + E A K+A ++ K +++ G + G T A+S TD + Sbjct: 146 VSVEVAAKMALQYWR--GRGLPGKRRLMTWRGGYHGDTFLAMSICDPHGGMHSLWTDVLA 203 Query: 194 YDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPI-QGEAGVVVPDPGYLMGVREL 252 F P +P Y+ + A +AA +VEP+ QG G+ DP YL +R++ Sbjct: 204 AQVFAPQVPRDYDPAYSAAFEAQLAQHAGELAAVVVEPVVQGAGGMRFHDPRYLHDLRDI 263 Query: 253 CTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIML 312 C R++VL I DEI TG RTG A D+ V PDI+ +GKAL+GG ++A LC D+ Sbjct: 264 CRRYEVLLIFDEIATGFGRTGALFAADHAGVSPDIMCVGKALTGGYLSLAATLCTADVAH 323 Query: 313 TIKPGE-----HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPS-D 366 TI G HG T+ NPL C V++A++E+L ++ +L L L + Sbjct: 324 TISAGAAGALMHGPTFMANPLACAVSVASVELLLGQDWRTRITELAAGLTAGLDTARALP 383 Query: 367 VVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELR 426 VT VR G + I + D D G+ +P +++ PP + E+ Sbjct: 384 AVTDVRVCGAIGVIE--CDRPVDLAVATPAALDRGVWLRPFR-NLVYAMPPYICTPAEIT 440 Query: 427 ESIEIINKT 435 + + + Sbjct: 441 QITSAMVEV 449 >6GIO-D nrPDB Length = 439 Score = 301 bits (770), Expect = 5e-82, Method: Composition-based stats. Identities = 108/434 (24%), Positives = 183/434 (42%), Gaps = 44/434 (10%) Query: 37 PPTSDDIFEREYKYGA--HNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCH 94 T + ER+ + A P++L GKG L + GR D S G+ H Sbjct: 1 MQTPLSLRERDARVIAEIGRLRFSPLSLIGGKGNRLIEEGGRSILDLSGSAGPAALGYGH 60 Query: 95 PKIVNALKSQVDKLTLTSRAFYNN----VLGEYEEYITKLFNYHKVLPMNTGVEAGETAC 150 P IV A++ V + S Y N L E IT +V ++G +A + A Sbjct: 61 PAIVEAVEKSVRDMAGASLLLYPNEAAVSLAEDLLRITPGNGERRVWFGHSGSDANDCAV 120 Query: 151 KLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYN 210 ++ +++I+ G++ G ++ S PG ++PY Sbjct: 121 RVLTA--------ATKRSRIISFIGSYHGNLTGSMGISGHTAMTHTL--PRPGVLLLPYP 170 Query: 211 D-----------LPALERALQ----DPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTR 255 D L L+ VAA +EPI + G+VVP P +L +++ C + Sbjct: 171 DPFRPRFSAEAVLELLDYHFATSCPPEQVAAVFIEPILSDGGLVVPPPAFLEALQDRCRK 230 Query: 256 HQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIK 315 H +L + DE++ GL RTG +E + PD+V+ G GG P+SAV+ +M Sbjct: 231 HGILVVVDEVKVGLGRTGLMHCFQHEGLEPDMVVFG-KGLGGGLPLSAVVGPQWVMDH-A 288 Query: 316 PGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKL--PSDVVTAVRG 373 P T GNP+ A L +E + LA+ ++++G I + L +L ++ VRG Sbjct: 289 PAFVLQTTAGNPVATAAGRAVLNTIERQGLAQRSERVGGIFADRLRRLSDKHSIIGDVRG 348 Query: 374 KGLLNAIVIKETKDWD-------AWKVCLRLRDNG--LLAKPTHGDIIRFAPPLVIKEDE 424 +GL + + + K+ R G + +++ F PPL + E E Sbjct: 349 RGLAIGVDLVSDRGSREPAPVTTTAKIIYRGYQLGAAFTYVGLNANVLEFMPPLTLTEPE 408 Query: 425 LRESIEIINKTILS 438 + E+ +I+++ I Sbjct: 409 IDEAADIVDQAIGD 422 >4GSA-A nrPDB Length = 432 Score = 293 bits (751), Expect = 8e-80, Method: Composition-based stats. Identities = 102/405 (25%), Positives = 165/405 (40%), Gaps = 38/405 (9%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLT-LTSRAFYN 117 P+ +R K Y WDV+G +Y D++ ++ GH HP+++ ALK ++K T + Sbjct: 40 PIVFDRVKDAYAWDVDGNRYIDYVGTWGPAICGHAHPEVIEALKVAMEKGTSFGAPCALE 99 Query: 118 NVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNF 177 NVL E + + V +N+G EA +L R + + KI+ G + Sbjct: 100 NVLAEMVN--DAVPSIEMVRFVNSGTEACMAVLRLMRAY--------TGRDKIIKFEGCY 149 Query: 178 WGRTLSAISSSTDPTSYDGFGPFMPGFD--------IIPYNDLPALERALQD--PNVAAF 227 G + + + G P PG PYNDL A++ + +A Sbjct: 150 HGHADMFLVKAGSGVATLGL-PSSPGVPKKTTANTLTTPYNDLEAVKALFAENPGEIAGV 208 Query: 228 MVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDI 287 ++EPI G +G +VPD G+L G+RE+ H L + DE+ TG R + V PD+ Sbjct: 209 ILEPIVGNSGFIVPDAGFLEGLREITLEHDALLVFDEVMTGF-RIAYGGVQEKFGVTPDL 267 Query: 288 VLLGKALSGGLYPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAALEVLEEEN 344 LGK + GGL PV A +IM + P T GNPL I LE+L + Sbjct: 268 TTLGKIIGGGL-PVGAYGGKREIMQLVAPAGPMYQAGTLSGNPLAMTAGIKTLELLRQPG 326 Query: 345 LAENADKLGIILRNELMKLPSDVVTAVRG---KGLLNAIVIKETKDWDAWKVCLRLRDNG 401 E D++ L + L+ + + A G G+ + L+ Sbjct: 327 TYEYLDQITKRLSDGLLAIAQETGHAACGGQVSGMFGFFFTEGPVHNYEDAKKSDLQKFS 386 Query: 402 LLAKPTHGDIIRFAP--------PLVIKEDELRESIEIINKTILS 438 + I AP L E+++ ++ + + Sbjct: 387 RFHRGMLEQGIYLAPSQFEAGFTSLAHTEEDIDATLAAARTVMSA 431 >4E77-A nrPDB Length = 429 Score = 293 bits (750), Expect = 1e-79, Method: Composition-based stats. Identities = 96/407 (23%), Positives = 162/407 (39%), Gaps = 41/407 (10%) Query: 58 LPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYN 117 +P+ +ER G YL+DV+G+ Y D++ S+ + GH HP I A+ V++ Sbjct: 35 IPLFIERADGAYLFDVDGKAYIDYVGSWGPMILGHNHPAIRQAVIEAVERGLSFGAPTEM 94 Query: 118 NVLGEYEEYITKLFN-YHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGN 176 V + + +T L V +N+G EA +A +LAR + + KI+ G Sbjct: 95 EV--KMAQLVTDLVPTMDMVRMVNSGTEATMSAIRLARGY--------TGRDKIIKFEGC 144 Query: 177 FWGR-------TLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQ--DPNVAAF 227 + G S + P S F YNDL ++ +A + VA Sbjct: 145 YHGHADCLLVKAGSGALTLGQPNSPGVPTDFAKHTLTCTYNDLASVRQAFEQYPQEVACI 204 Query: 228 MVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDI 287 +VEP+ G + P P +L G+R LC L I DE+ TG R A DY +V PD+ Sbjct: 205 IVEPVAGNMNCIPPLPEFLPGLRALCDEFGALLIIDEVMTGF-RVALAGAQDYYHVIPDL 263 Query: 288 VLLGKALSGGLYPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAALEVLEEEN 344 LGK + GG+ PV A ++M + P T GNP+ A L + + Sbjct: 264 TCLGKIIGGGM-PVGAFGGRREVMNALAPTGPVYQAGTLSGNPIAMAAGFACLTEISQVG 322 Query: 345 LAENADKLGIILRNELMKLP-SDVVTAVRG-KGLLNAIVIKETKDWDAWKVCLRL----- 397 + E +L L L + + V G + + ++ + Sbjct: 323 VYETLTELTDSLATGLRHAAKEENIPLVVNHVGGMFGLFFTNADTVTCYQDVMNCDVERF 382 Query: 398 -------RDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTIL 437 + G+ P+ + F L +++++++ + Sbjct: 383 KRFFHLMLEEGVYLAPSAFEA-GFM-SLAHSNEDIQKTVNAARRCFA 427 >5HDM-A nrPDB Length = 434 Score = 290 bits (743), Expect = 7e-79, Method: Composition-based stats. Identities = 100/404 (24%), Positives = 169/404 (41%), Gaps = 38/404 (9%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLT-LTSRAFYN 117 PV ++ KG +WD++G +Y D++ S+ GH +++ AL + K T + Sbjct: 42 PVLIDSVKGSKMWDIDGNEYIDYVGSWGPAIIGHADDEVLAALAETMKKGTSFGAPCLLE 101 Query: 118 NVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNF 177 NVL E I+ + + V +N+G EA +LAR + K K + G + Sbjct: 102 NVLAEMV--ISAVPSIEMVRFVNSGTEACMGVLRLARAF--------TNKEKFIKFEGCY 151 Query: 178 WGRTLSAISSSTDPTSYDGFGPFMPGFD--------IIPYNDLPALERALQDP--NVAAF 227 G + + + + G P PG PYNDL A+E+ ++A Sbjct: 152 HGHANAFLVKAGSGVATLGL-PDSPGVPKAATSDTLTAPYNDLEAVEKLFAAHKGEISAV 210 Query: 228 MVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDI 287 ++EP+ G +G + P P ++ G+R+L + VL I DE+ TG R A +Y + PD+ Sbjct: 211 ILEPVVGNSGFIPPTPEFINGLRQLTKDNGVLLIFDEVMTGF-RLAYGGAQEYFGITPDL 269 Query: 288 VLLGKALSGGLYPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAALEVLEEEN 344 LGK + GGL PV A DIM + P T GNPL I L+ L++ Sbjct: 270 TTLGKIIGGGL-PVGAYGGRRDIMEMVAPAGPMYQAGTLSGNPLAMTAGIHTLKRLKQAG 328 Query: 345 LAENADKLGIILRNELMKLPSDVVTAVRG--KGLLNAIVIKETKDWDAWKVCLRLRDN-G 401 E DK+ L N +++ + G + E ++ + G Sbjct: 329 TYEYLDKITKELTNGILEAGKKTGHPMCGGYISGMFGFFFAEGPVYNFADSKKSDTEKFG 388 Query: 402 LLAKPTHGDIIRFAP--------PLVIKEDELRESIEIINKTIL 437 + + + FAP L ++++ +I + + Sbjct: 389 RFFRGMLEEGVYFAPSQFEAGFTSLAHTPEDIQLTIAAAERVLS 432 >3L44-A nrPDB Length = 434 Score = 289 bits (741), Expect = 1e-78, Method: Composition-based stats. Identities = 112/351 (31%), Positives = 163/351 (46%), Gaps = 29/351 (8%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNN 118 P+A+ERGKG Y WDV+G KY D+L++Y + GH HP I A+ + + L Sbjct: 38 PIAMERGKGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITKAITTAAENGVLYGTPTALE 97 Query: 119 VLGEYEEYITK-LFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNF 177 V ++ + + + + KV +N+G EA T ++AR + + KI+ AG + Sbjct: 98 V--KFAKMLKEAMPALDKVRFVNSGTEAVMTTIRVARAY--------TGRTKIMKFAGCY 147 Query: 178 WGRT-------LSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQ--DPNVAAFM 228 G + S S+ P S +P+N++ L+ AL VAA + Sbjct: 148 HGHSDLVLVAAGSGPSTLGTPDSAGVPQSIAQEVITVPFNNVETLKEALDKWGHEVAAIL 207 Query: 229 VEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIV 288 VEPI G G+V P PG+L V EL L I DE+ T R A D V PD+ Sbjct: 208 VEPIVGNFGIVEPKPGFLEKVNELVHEAGALVIYDEVITAF-RFMYGGAQDLLGVTPDLT 266 Query: 289 LLGKALSGGLYPVSAVLCDDDIMLTIK---PGEHGSTYGGNPLGCRVAIAALEVLEEENL 345 LGK + GGL P+ A +IM + P T GNP IA LEVL++E L Sbjct: 267 ALGKVIGGGL-PIGAYGGKKEIMEQVAPLGPAYQAGTMAGNPASMASGIACLEVLQQEGL 325 Query: 346 AENADKLGIILRNELMKLPSDVVTAV---RGKGLLNAIVIKET-KDWDAWK 392 E D+LG L +++ + + R KG L T +D+DA + Sbjct: 326 YEKLDELGATLEKGILEQAAKHNIDITLNRLKGALTVYFTTNTIEDYDAAQ 376 >2JJG-A nrPDB Length = 449 Score = 289 bits (741), Expect = 1e-78, Method: Composition-based stats. Identities = 120/458 (26%), Positives = 188/458 (41%), Gaps = 55/458 (12%) Query: 20 SSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWD-VEGRKY 78 ++V + ++A + P T D + E + + + + L R G YL D + GR+Y Sbjct: 2 AAVVKSVALAGR-----PTTPDRVHEVLGRSMLVDGLDIVLDLTRSGGSYLVDAITGRRY 56 Query: 79 FDFLSSYSAVNQGHCHPKIVNALKSQVDKLTL-----TSRAFYNNVLGEYEEYITKLFN- 132 D + ++ G P +V+ + + + ++ Y+ + + E ++ Sbjct: 57 LDMFTFVASSALGMNPPALVDDREFHAELMQAALNKPSNSDVYSVAMARFVETFARVLGD 116 Query: 133 --YHKVLPMNTGVEAGETACKLARKWG---YTVKGIQKY-KAKIVFAAGNFWGRTLSAIS 186 + + G A E A K A W GI +++ G F GR+ +S Sbjct: 117 PALPHLFFVEGGALAVENALKAAFDWKSRHNQAHGIDPALGTQVLHLRGAFHGRSGYTLS 176 Query: 187 SS-TDPTSYDGFGPFMPGFDIIPYNDLPALERALQDP----------------------N 223 + T PT F P FD P D P + L +P + Sbjct: 177 LTNTKPTITARF----PKFDW-PRIDAPYMRPGLDEPAMAALEAEALRQARAAFETRPHD 231 Query: 224 VAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENV 283 +A F+ EPIQGE G P + +RELC L I DE+QTG TG A +V Sbjct: 232 IACFVAEPIQGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLTGTAWAYQQLDV 291 Query: 284 RPDIVLLGK--ALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLE 341 PDIV GK + G + D++ P ST+GGN A LEV+E Sbjct: 292 APDIVAFGKKTQVCGVMAGRRVDEVADNVFAV--PSRLNSTWGGNLTDMVRARRILEVIE 349 Query: 342 EENLAENADKLGIILRNELMKLPSDV---VTAVRGKGLLNAIVIKETKDWDAWKVCLRLR 398 E L E A + G LR L +L +D V RG+GL+ A + T D D ++ +L Sbjct: 350 AEGLFERAVQHGKYLRARLDELAADFPAVVLDPRGRGLMCAFSLPTTADRD--ELIRQLW 407 Query: 399 DNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTI 436 ++ P D +RF PPL + E+ +I + + Sbjct: 408 QRAVIVLPAGADTVRFRPPLTVSTAEIDAAIAAVRSAL 445 >2ZUK-A nrPDB Length = 439 Score = 287 bits (736), Expect = 5e-78, Method: Composition-based stats. Identities = 103/436 (23%), Positives = 197/436 (45%), Gaps = 45/436 (10%) Query: 36 GPPTSDDIFEREYKYGAH--NYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHC 93 G + +++R+ + P+A+ G+G L + GR+ D ++ A + G+ Sbjct: 1 GSHMTKALYDRDGAAIGNLQKLRFFPLAISGGRGARLIEENGRELIDLSGAWGAASLGYG 60 Query: 94 HPKIVNALKSQVDKLTLTSRAFYNNVLG-EYEEYITKLF---NYHKVLPMNTGVEAGETA 149 HP IV A+ + + +N E + F HK+ ++G +A E A Sbjct: 61 HPAIVAAVSAAAANPAGATILSASNAPAVTLAERLLASFPGEGTHKIWFGHSGSDANEAA 120 Query: 150 CKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPY 209 + K ++ ++ AG + G T+ +++ S D G ++PY Sbjct: 121 YRAIVK--------ATGRSGVIAFAGAYHGCTVGSMAFSGHSVQADAAK--ADGLILLPY 170 Query: 210 ND-----------------LPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVREL 252 D L A+ ++ A +EPIQ + G++VP G+L ++ Sbjct: 171 PDPYRPYRNDPTGDAILTLLTEKLAAVPAGSIGAAFIEPIQSDGGLIVPPDGFLRKFADI 230 Query: 253 CTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIML 312 C H +L + DE++ GLAR+GR ++E PDI++LG GG P+SAV+ +I+ Sbjct: 231 CRAHGILVVCDEVKVGLARSGRLHCFEHEGFVPDILVLG-KGLGGGLPLSAVIAPAEILD 289 Query: 313 TIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLP--SDVVTA 370 T GNP+ +A LE ++ ++L A++ G +LR+ L +L ++ Sbjct: 290 -CASAFAMQTLHGNPISAAAGLAVLETIDRDDLPAMAERKGRLLRDGLSELAKRHPLIGD 348 Query: 371 VRGKGLLNAIVI------KETKDWDAWKVCLRLRDNGLLAK--PTHGDIIRFAPPLVIKE 422 +RG+GL + + +E + K+ R GL+ +G+++ F PPL I E Sbjct: 349 IRGRGLACGMELVCDRQSREPARAETAKLIYRAYQLGLVVYYVGMNGNVLEFTPPLTITE 408 Query: 423 DELRESIEIINKTILS 438 ++ ++++++++ Sbjct: 409 TDIHKALDLLDRAFSE 424 >3I4J-A nrPDB Length = 430 Score = 286 bits (732), Expect = 1e-77, Method: Composition-based stats. Identities = 116/408 (28%), Positives = 190/408 (46%), Gaps = 41/408 (10%) Query: 57 PLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTL-TSRAF 115 P PVA+ RG+G++L+D GR+Y D S N GH ++ + +Q +L F Sbjct: 11 PYPVAV-RGEGVFLYDDAGRRYLDGSSGALVANIGHGRAEVGERMAAQAARLPFVHGSQF 69 Query: 116 YNNVLGEYEEYITKLFNYHKVLP--MNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFA 173 ++VL EY + + ++ G EA E+A KLAR++ V+ + + K++ Sbjct: 70 SSDVLEEYAGRLARFVGLPTFRFWAVSGGSEATESAVKLARQY--HVERGEPGRFKVITR 127 Query: 174 AGNFWGRTLSAISSSTDPTSYDGFGPFM--PGFDIIPYND-----------LPALERALQ 220 ++ G +L ++++S + + P M + +P D L AL Sbjct: 128 VPSYHGASLGSLAASGMGARRELYTPLMRPEAWPKLPKPDPARNGAEDAEGLRALLEREG 187 Query: 221 DPNVAAFMVEPIQGEA-GVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLA-V 278 VAAFM EP+ G + + P PGY VR++C ++FIADE+ +G+ R G LA Sbjct: 188 PETVAAFMAEPVVGASDAALAPAPGYYERVRDICDEAGIIFIADEVMSGMGRCGSPLALS 247 Query: 279 DYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE----HGSTYGGNPLGCRVAI 334 + V PDI +LGK L+ G P++ +L + T+ G HG TY G+P+ + Sbjct: 248 RWSGVTPDIAVLGKGLAAGYAPLAGLLAAPQVYETVMGGSGAFMHGFTYAGHPVSVAAGL 307 Query: 335 AALEVLEEENLAENADKLGIILRNELMKLPSDV--VTAVRGKGLLNAIVIKETKDWDAWK 392 + L+++E E+L A + G L L L + + VRG GLL +V+ + A++ Sbjct: 308 SVLDIVEREDLTGAAKERGAQLLAGLQALQARFPQMMQVRGTGLLLGVVLGDLATGQAFE 367 Query: 393 -------VCLRLRDNGLLAKP-------THGDIIRFAPPLVIKEDELR 426 + GL+ P GD + PPL I E+ Sbjct: 368 TPGIASRIGAAALKRGLITYPGSGAEPNGRGDHLLLGPPLSITAAEVD 415 >4AOA-A nrPDB Length = 454 Score = 286 bits (731), Expect = 2e-77, Method: Composition-based stats. Identities = 106/445 (23%), Positives = 178/445 (40%), Gaps = 43/445 (9%) Query: 15 SRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAH-------NYHPLPVALERGKG 67 S H+++ A + A ++ P S FE + +Y Y P P+ + RG+G Sbjct: 19 SHMTHAAIDQALADAYRRFTDANPASQRQFEAQARYMPGANSRSVLFYAPFPLTIARGEG 78 Query: 68 IYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYI 127 LWD +G +Y DF++ Y+A GH P+I +A+ + + +N + G I Sbjct: 79 AALWDADGHRYADFIAEYTAGVYGHSAPEIRDAVIEAMQGG--INLTGHNLLEGRLARLI 136 Query: 128 TKLF-NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAIS 186 + F ++ N+G EA A A + + KIV +G + G + Sbjct: 137 CERFPQIEQLRFTNSGTEANLMALTAALHF--------TGRRKIVVFSGGYHG---GVLG 185 Query: 187 SSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQ--DPNVAAFMVEPIQGEAGVVVPDPG 244 P+ PF F ++PYND ++ P +A +VEP+QG +G + P Sbjct: 186 FGARPSPTTV--PF--DFLVLPYNDAQTARAQIERHGPEIAVVLVEPMQGASGCIPGQPD 241 Query: 245 YLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAV 304 +L +RE T+ L + DE+ T +R + +R D+ LGK + GG+ A Sbjct: 242 FLQALRESATQVGALLVFDEVMT--SRLAPHGLANKLGIRSDLTTLGKYIGGGM-SFGAF 298 Query: 305 LCDDDIMLTIKPG----EHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNEL 360 D+M P H T+ N + A L L A + G LR L Sbjct: 299 GGRADVMALFDPRTGPLAHSGTFNNNVMTMAAGYAGLTKLFTPEAAGALAERGEALRARL 358 Query: 361 MKLPSDVVTAVRGKG---LLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAP- 416 L ++ A++ G L+NA ++ + R LL + I +P Sbjct: 359 NALCANEGVAMQFTGIGSLMNAHFVQGDVRSSEDLAAVDGRLRQLLFFHLLNEDIYSSPR 418 Query: 417 -----PLVIKEDELRESIEIINKTI 436 L + + ++ + I I Sbjct: 419 GFVVLSLPLTDADIDRYVAAIGSFI 443 >1OHW-A nrPDB Length = 472 Score = 285 bits (730), Expect = 3e-77, Method: Composition-based stats. Identities = 92/466 (19%), Positives = 177/466 (37%), Gaps = 70/466 (15%) Query: 31 KKTVQGPPTSD---DIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSA 87 K V GP + + + + H + E +G YL DV+G + D S S+ Sbjct: 19 KTEVPGPRSRELMKQLNIIQNAEAVHFFCNY----EESRGNYLVDVDGNRMLDLYSQISS 74 Query: 88 VNQGHCHPKIVNALKSQVDKLTLTSRAFYN-----NVLGEYEEYITKLF--NYHKVLPMN 140 + G+ HP +V ++ + T +R N + + E + + +++ M Sbjct: 75 IPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMA 134 Query: 141 TGVEAGETACKLARKWGYTVKGIQKYKAK------------------IVFAAGNFWGRTL 182 G + E A K W + + Q +K I+ G F GRT+ Sbjct: 135 CGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTM 194 Query: 183 SAISSSTDPTSYD----GFGPFMPGFDIIPYNDLPALERALQDP---------------- 222 ++++ + F + F + Y ++ Q+ Sbjct: 195 GCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRK 254 Query: 223 ---NVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVD 279 VA +VEPIQ E G + +R++ +H F+ DE+QTG TG++ A + Sbjct: 255 KKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHE 314 Query: 280 YENVR--PDIVLLGKA-LSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAA 336 + + D++ K ++GG + + P +T+ G+P + Sbjct: 315 HWGLDDPADVMTFSKKMMTGGFF-------HKEEFRPNAPYRIFNTWLGDPSKNLLLAEV 367 Query: 337 LEVLEEENLAENADKLGIILRNELMKLPSD---VVTAVRGKGLLNAIVIKETKDWDAWKV 393 + +++ E+L NA G +L L+ L + ++ VRG+G + + + K+ Sbjct: 368 INIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRN--KL 425 Query: 394 CLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF 439 R+ G++ IRF P LV ++ + I + + F Sbjct: 426 ISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADF 471 >3K28-A nrPDB Length = 429 Score = 285 bits (729), Expect = 3e-77, Method: Composition-based stats. Identities = 101/375 (26%), Positives = 164/375 (43%), Gaps = 41/375 (10%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFY-N 117 P+ +ERGKG ++D++G +Y D++ S+ + GH + ++V ALK+ ++ T Sbjct: 36 PLFMERGKGSKVYDIDGNEYIDYVLSWGPLIHGHANDRVVEALKAVAERGTSFGAPTEIE 95 Query: 118 NVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNF 177 N L + I ++ + V +N+G EA +A +LAR + + KI+ G + Sbjct: 96 NKLAKLV--IERVPSIEIVRMVNSGTEATMSALRLARGY--------TGRNKILKFIGCY 145 Query: 178 WGRTLSAISSSTDPTSYDGFGPFMPGF--------DIIPYNDLPALERALQD--PNVAAF 227 G S + + + G P PG + YNDL +++ A + ++A Sbjct: 146 HGHGDSLLIKAGSGVATLGL-PDSPGVPEGVAKNTITVAYNDLESVKYAFEQFGDDIACV 204 Query: 228 MVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDI 287 +VEP+ G GVV P PG+L G+RE+ ++ L I DE+ TG R Y V PD+ Sbjct: 205 IVEPVAGNMGVVPPQPGFLEGLREVTEQNGALLIFDEVMTGF-RVAYNCGQGYYGVTPDL 263 Query: 288 VLLGKALSGGLYPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAALEVLEEEN 344 LGK + GGL PV A +IM + P T GNPL L L E+ Sbjct: 264 TCLGKVIGGGL-PVGAYGGKAEIMRQVAPSGPIYQAGTLSGNPLAMAAGYETLVQLTPES 322 Query: 345 LAENADKLGIILRNELMKLPSDVV--TAVRGKGLLNAIVIKETK--DWDAWKVC------ 394 E ++ +L L K + G + I + ++DA K Sbjct: 323 YVE-FERKAEMLEAGLRKAAEKHGIPHHINRAGSMIGIFFTDEPVINYDAAKSSNLQFFA 381 Query: 395 ---LRLRDNGLLAKP 406 + + G+ P Sbjct: 382 AYYREMVEQGVFLPP 396 >5I92-A nrPDB Length = 435 Score = 282 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 82/320 (25%), Positives = 137/320 (42%), Gaps = 25/320 (7%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNN 118 P+ + +G Y+ D + ++Y D++ S+ + GH HP +++A++ Q+D Sbjct: 41 PLFFKHAEGAYVLDEDDKRYVDYVGSWGPMILGHSHPDVLDAVRRQLDHGLSYGAPTALE 100 Query: 119 VLGEYEEYITKLF-NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNF 177 V E + + + + V +++G EA +A +LAR + + I+ G + Sbjct: 101 V--EMADLVCSMVPSMEMVRMVSSGTEATMSAIRLARGY--------TGRDSIIKFEGCY 150 Query: 178 WGRT-------LSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQD--PNVAAFM 228 G + S + P S F +P+ND+ A+ + L + VA + Sbjct: 151 HGHSDSLLVKAGSGALTFGVPNSPGVPAAFAKHTLTLPFNDIEAVRKTLGEVGKEVACII 210 Query: 229 VEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIV 288 VEP+ G V P PG+L G+RE C H V+ I DE+ TG R A Y V PD+ Sbjct: 211 VEPVAGNMNCVPPAPGFLEGLREACDEHGVVLIFDEVMTGF-RVALGGAQAYYGVTPDLS 269 Query: 289 LLGKALSGGLYPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAALEVLEEENL 345 GK + GG+ PV A +IM I P T GNPL + L ++ Sbjct: 270 TFGKIIGGGM-PVGAFGGKREIMQQISPLGPVYQAGTLSGNPLAMAAGLTTLRLISRPGF 328 Query: 346 AENADKLGIILRNELMKLPS 365 + + + L + Sbjct: 329 HDELTAYTTRMLDGLQQRAD 348 >3BS8-A nrPDB Length = 438 Score = 280 bits (717), Expect = 8e-76, Method: Composition-based stats. Identities = 105/400 (26%), Positives = 168/400 (42%), Gaps = 39/400 (9%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNN 118 P+ +ERGKG ++D++G +Y D++ S+ + GH + ++V +LK + T Sbjct: 44 PIFMERGKGSKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAP--TE 101 Query: 119 VLGEYEEYIT-KLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNF 177 V E + + ++ + V +++G EA +A +LAR + + KI+ G + Sbjct: 102 VENELAKLVIDRVPSVEIVRMVSSGTEATMSALRLARGY--------TGRNKILKFEGCY 153 Query: 178 WGRTLSAISSSTDPTSYDGFGPFMPGF--------DIIPYNDLPALERALQD--PNVAAF 227 G S + + + G P PG +PYNDL +++ A Q ++A Sbjct: 154 HGHGDSLLIKAGSGVATLGL-PDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGV 212 Query: 228 MVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDI 287 +VEP+ G GVV P G+L G+R++ ++ L I DE+ TG R A Y V PD+ Sbjct: 213 IVEPVAGNMGVVPPQEGFLQGLRDITEQYGSLLIFDEVMTGF-RVDYNCAQGYFGVTPDL 271 Query: 288 VLLGKALSGGLYPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAALEVLEEEN 344 LGK + GGL PV A +IM I P T GNPL + L+ L + Sbjct: 272 TCLGKVIGGGL-PVGAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQL-TPD 329 Query: 345 LAENADKLGIILRNEL--MKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGL 402 +N K G L + + G + T + + D L Sbjct: 330 SYKNFIKKGDRLEEGISKAAEAHGIPHTFNRAGSMIGFFF--TNEPVINYETAKASDLKL 387 Query: 403 LAKPTHG--DIIRFAPP-----LVIKEDELRESIEIINKT 435 A G + F PP L + E IE + Sbjct: 388 FASYYKGMANEGVFLPPSQFEGLFLSTAHTDEDIENTIQA 427 >2E7U-A nrPDB Length = 424 Score = 273 bits (699), Expect = 9e-74, Method: Composition-based stats. Identities = 107/409 (26%), Positives = 176/409 (43%), Gaps = 50/409 (12%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDK-LTLTSRAFYN 117 P L RG+G Y+WD +G +Y D++ S+ + GH HPK++ ++ +++ LT + + Sbjct: 35 PPFLVRGEGAYVWDADGNRYLDYVMSWGPLILGHAHPKVLARVRETLERGLTFGAPSPLE 94 Query: 118 NVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNF 177 L + + + V +N+G EA +A +LAR + + IV GN+ Sbjct: 95 VALAKKVKRAYPFVDL--VRFVNSGTEATMSALRLARGY--------TGRPYIVKFRGNY 144 Query: 178 WGRTLS-------AISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQ--DPNVAAFM 228 G + P+S + ++ YND L L+ +AA + Sbjct: 145 HGHADGLLVEAGSGALTLGVPSSAGVPEEYAKLTLVLEYNDPEGLREVLKRRGEEIAAII 204 Query: 229 VEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIV 288 EP+ G AGV+VP +L + E + VL IADE+ TG R A + ++PD+V Sbjct: 205 FEPVVGNAGVLVPTEDFLKALHE-AKAYGVLLIADEVMTGF-RLAFGGATELLGLKPDLV 262 Query: 289 LLGKALSGGLYPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAALEVLEE-EN 344 LGK L GGL P +A +IM + P T GNPL +A LE+LEE Sbjct: 263 TLGKILGGGL-PAAAYAGRREIMEKVAPLGPVYQAGTLSGNPLAMAAGLATLELLEENPG 321 Query: 345 LAENADKLGIILRNELMKLPSDVV--TAVRGKGLLNAIVIKETKDW---DAWKVCLRLRD 399 + LG L L ++ + V G + + E DA + L Sbjct: 322 YYAYLEDLGARLEAGLKEVLKEKGLPHTVNRVGSMITVFFTEGPVVTFQDARRTDTELFK 381 Query: 400 ---NGLLAKPTHGDIIRFAPPLVI---------KEDELRESIEIINKTI 436 +GLL + + PP +E+++ +++E + K + Sbjct: 382 RFFHGLLDRGIY------WPPSNFEAAFLSVAHREEDVEKTLEALRKAL 424 >2EPJ-A nrPDB Length = 434 Score = 253 bits (647), Expect = 8e-68, Method: Composition-based stats. Identities = 86/301 (28%), Positives = 141/301 (46%), Gaps = 27/301 (8%) Query: 57 PLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFY 116 P P ++RG+G YL+ V+G + D + +Y + GH HP+++ A++ + + L Sbjct: 37 PYPFYVKRGEGAYLYTVDGARIVDLVLAYGPLILGHKHPRVLEAVEEALARGWLYGAPGE 96 Query: 117 NNVLGEYEEYITKLFN-YHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAG 175 VL E I + +N+G EA TA +LAR + + I+ G Sbjct: 97 AEVL--LAEKILGYVKRGGMIRFVNSGTEATMTAIRLARGY--------TGRDLILKFDG 146 Query: 176 NFWGRTLSAISSSTDPTSYDGFGPFMPGFD--------IIPYNDLPALERALQD--PNVA 225 + G + + ++ ++ G P G + PYND+ ALER + +A Sbjct: 147 CYHGSHDAVLVAAGSAAAHYGV-PTSAGVPEAVARLTLVTPYNDVEALERVFAEYGDRIA 205 Query: 226 AFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRP 285 +VEP+ AGV+ P +L ++ L L I DE+ TG R G A Y N+ Sbjct: 206 GVIVEPVIANAGVIPPRREFLAALQRLSRESGALLILDEVVTGF-RLGLEGAQGYFNIEG 264 Query: 286 DIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAIAALEVLEE 342 DI++LGK + GG +PV AV ++M + P + T+ +P+ +A L+ LEE Sbjct: 265 DIIVLGKIIGGG-FPVGAVAGSREVMSLLTPQGKVFNAGTFNAHPITMAAGLATLKALEE 323 Query: 343 E 343 E Sbjct: 324 E 324 >2YKV-A nrPDB Length = 465 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 95/431 (22%), Positives = 153/431 (35%), Gaps = 43/431 (9%) Query: 22 VASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDF 81 V++ ++++ G T +F R P P+ + +G G DV+G Y +F Sbjct: 56 VSAGHHERARRSMPGGNTRSILFHR----------PFPLVIAQGTGSRFQDVDGHAYVNF 105 Query: 82 LSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLF-NYHKVLPMN 140 L Y+A GH HP I A++ + S N L + E + F + V N Sbjct: 106 LGEYTAGLFGHSHPVIRAAVERALAVGLNLSTQTENEAL--FAEAVCDRFPSIDLVRFTN 163 Query: 141 TGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPF 200 +G EA A A + ++ G + G L +S PT+ Sbjct: 164 SGTEANLMALATATA--------ITGRKTVLAFDGGYHG-GLLNFASGHAPTNAPY---- 210 Query: 201 MPGFDIIPYNDLPALERALQ--DPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQV 258 + YND+ L+ + AA +VEP+ G G V + +L +R +R Sbjct: 211 --HVVLGVYNDVEGTADLLKRHGHDCAAILVEPMLGAGGCVPAERAFLDLLRAEASRCGA 268 Query: 259 LFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE 318 L I DE+ T +R A + + D+ LGK + GG+ A D+M P Sbjct: 269 LLIFDEVMT--SRLSGGGAQEMLGISADLTTLGKYIGGGM-SFGAFGGRRDLMERFDPAR 325 Query: 319 -----HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVRG 373 H T+ N L AAL + A + G R L ++ + ++ Sbjct: 326 DGAFAHAGTFNNNILTMSAGHAALTQIYTRQAASDLSASGDRFRANLNRIAVENQAPLQF 385 Query: 374 KGL--LNAIVIKETKDWDAWKVCLRLRDNG-LLAKPTHGDIIRFAPP--LVIKEDELRES 428 GL L I A V + L I AP + + Sbjct: 386 TGLGSLGTIHFSRAPIRSAGDVRAADQQLKELFFFHMLRKGIYLAPRGMYALSLEIADAG 445 Query: 429 IEIINKTILSF 439 + + + F Sbjct: 446 RDAFAEALADF 456 >4ZM4-A nrPDB Length = 447 Score = 235 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 88/356 (24%), Positives = 150/356 (42%), Gaps = 34/356 (9%) Query: 57 PLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFY 116 PLP+ + G L DVE + D Y G+ ++++A+ Q K +T Sbjct: 39 PLPLVVRSAGGCLLRDVEDGEIIDLNMGYGPHLFGYADREVLDAVADQFAKGHMTGLP-- 96 Query: 117 NNVLGEYEEYITKLF-NYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAG 175 + + I +L +V N+G EA +A +LAR + +V G Sbjct: 97 HELDARAGALIAELVPGVEQVRFANSGTEAVASALRLARA--------TTGRTLVVTFEG 148 Query: 176 NFWGRTLSAISSSTDPTSYDGFGP--FMPGF-DIIP----------YNDLPALERALQ-- 220 ++ G + + + + +G P +PG +IP +ND AL Sbjct: 149 HYHGWSETVLRAGKTALHMEGTRPTDVVPGALGMIPEALAHTVQLGWNDPDALRELFARD 208 Query: 221 DPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDY 280 +AA +VEP+ AGV+ P PG+L +REL R + + DE+ TG R R A + Sbjct: 209 GDRIAAVIVEPVLANAGVIPPAPGFLQLLRELTGRSGAMLVFDEVITGF-RVARGGAQER 267 Query: 281 ENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE--HGSTYGGNPLGCRVAIAALE 338 V PD+ +L + + GG +PV+A M + E H Y GN R +A L Sbjct: 268 YGVEPDLTVLSRVMGGG-FPVAAFGGRRHAMRMLASNEAHHAGVYAGNHAALRAVVAMLG 326 Query: 339 VLEE-ENLAENADKLGIILRNELMKLPS---DVVTAVRGKGLLNAIVIKETKDWDA 390 + +L E + G + + + ++ + V R L++ ++K + + A Sbjct: 327 KIRSLPDLYERLEDTGQYMEDTVREVFATEKRPVHINRVGTLMSVALLKGSAEPSA 382 >2CY8-A nrPDB Length = 453 Score = 217 bits (554), Expect = 6e-57, Method: Composition-based stats. Identities = 77/327 (23%), Positives = 139/327 (42%), Gaps = 30/327 (9%) Query: 55 YHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRA 114 + P + + +G++ DV+G Y DF + A+ GH HP++ A+ + + A Sbjct: 36 FDPHGLFISDAQGVHKTDVDGNVYLDFFGGHGALVLGHGHPRVNAAIAEALSHGVQYA-A 94 Query: 115 FYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAA 174 + + E + + K+ +G E A ++AR + + I+ Sbjct: 95 SHPLEVRWAERIVAAFPSIRKLRFTGSGTETTLLALRVARAF--------TGRRMILRFE 146 Query: 175 GNFWGRTLSAISSSTDPTSYDGFGPFMPGF--------DIIPYNDLPALERALQDP--NV 224 G++ G S+S + +D G PG +I +D+ + + ++ Sbjct: 147 GHYHG--WHDFSASGYNSHFD--GQPAPGVLPETTANTLLIRPDDIEGMREVFANHGSDI 202 Query: 225 AAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVR 284 AAF+ EP+ GV +L EL ++ LFI DE+ +G R G +V+ Sbjct: 203 AAFIAEPVGSHFGVTPVSDSFLREGAELARQYGALFILDEVISGF-RVGNHGMQALLDVQ 261 Query: 285 PDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE-----HGSTYGGNPLGCRVAIAALEV 339 PD+ L KA S G P + +D+M + G H T+ GNP+ AIAA++ Sbjct: 262 PDLTCLAKA-SAGGLPGGILGGREDVMGVLSRGSDRKVLHQGTFTGNPITAAAAIAAIDT 320 Query: 340 LEEENLAENADKLGIILRNELMKLPSD 366 + E+++ + LG R + L + Sbjct: 321 ILEDDVCAKINDLGQFAREAMNHLFAR 347 >5YKR-A nrPDB Length = 461 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 76/335 (22%), Positives = 128/335 (38%), Gaps = 45/335 (13%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNN 118 P+ ++ +G + D++G++Y DF S GH P + +A+ Q + + ++ Sbjct: 58 PLLVKEAQGARVTDIDGQQYVDFALGDSGAMFGHAQPAVADAIARQARRGSTLMLPTEDS 117 Query: 119 VLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFW 178 + E + + F + +A +L R + + K+V N+ Sbjct: 118 LWVGAE--LARRFGLPYWQVTTSATDANRFVLRLCR--------MLSGRDKVVVFNCNYH 167 Query: 179 GRTLSAISSSTDPTSYDGFGPFMPGFDIIP-------------YNDLPALERALQDPNVA 225 G S +D G +P + P +NDL ALE AL +VA Sbjct: 168 G------SVDESQVEFDAAGRMVPRAGVHPNGVRHATTTRLVEFNDLDALEAALAHGDVA 221 Query: 226 AFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRP 285 A + EP G+V P G+ G+REL RH V I DE T G + P Sbjct: 222 AVLTEPFMTNVGMVPPAEGFHAGLRELTRRHDVALIIDETHT--ISCGPAGYSGAHGLEP 279 Query: 286 DIVLLGKALSGGLYPVSAVLCDD-------DIMLTIKPGEH------GSTYGGNPLGCRV 332 D +LGK ++GG+ P + C ++ +PG+ G T GN L Sbjct: 280 DFFVLGKCIAGGI-PSAVWGCSQAQAERIWAVLPHFRPGQAINHFGFGGTLAGNALQLAA 338 Query: 333 AIAALEVLEEENLAENADKLGIILRNELMKLPSDV 367 A + E+ + +L L + ++ Sbjct: 339 MRATFAEVMTEDAYRHMFQLAAQLEAGVRATLEEL 373 >5DDW-A nrPDB Length = 523 Score = 214 bits (544), Expect = 8e-56, Method: Composition-based stats. Identities = 91/483 (18%), Positives = 166/483 (34%), Gaps = 111/483 (22%) Query: 63 ERGKGIYLW--DVEGRKY--FDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNN 118 R +G ++ D EGR+ D + ++ GH HP+I+ K+ +D T+ Sbjct: 29 VRAEGNTVYYLDDEGREVPVLDHACGFGSLIFGHNHPEIIAHAKAALDAGTVVHAQLSRQ 88 Query: 119 VLGEYEEYITKLFNYHK----------VLPMNTGVEAGETACK----------------- 151 I L + + + N+G EA E K Sbjct: 89 PRANQISRI--LNDIMRRETGRDDRYNAIFANSGAEANEICMKHAELERQERITALFAEI 146 Query: 152 -----LARKW------------------------------GYTVKGIQKYKAKIVFAAGN 176 AR+ + + + G+ Sbjct: 147 DAELDTAREALTTGTATLDTASLPLVGGGAGDVDGVIADIHRHNDERRAERPLFLTLDGS 206 Query: 177 FWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPN------------- 223 F G+ + +I + + F +P ++ + + ++D Sbjct: 207 FHGKLVGSIQLTQNEPWRTPFTALSSPARFLPADEPELIGKIVEDERRSVLTLSLDKDTV 266 Query: 224 ---------VAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGR 274 VAA VEP++G +G+ P + L + DE+QTG+ RTG Sbjct: 267 RVVERDFPVVAAIFVEPVRGGSGMKTVTPELAEELHRLRDTLGCPLVVDEVQTGIGRTGA 326 Query: 275 WLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAI 334 + +R D L KA+ GG+ S L D L H ST+ + L +A+ Sbjct: 327 FFGSALLGIRGDYYTLAKAIGGGIVKNSVALIRQDRFLPAMEVIHSSTFAKDGLSASIAL 386 Query: 335 AALEVLEEEN--LAENADKLGIILRNEL---MKLPSDVVTAVRGKGLLNAIVIKETKDWD 389 LE++E + + + + G L L SDVV+AV G GL+ A+ +++ + Sbjct: 387 KVLEMVEADGGRVYQRVRERGQRLEAMLESVRADHSDVVSAVWGTGLMLALELRDQSNAT 446 Query: 390 AWKVCLR--------------LRDNGLLAKPTH--GDIIRFAPPLVIKEDELRESIEIIN 433 + + + LR++ + P +RF+P L I ++E+ + + Sbjct: 447 SQAIREKAAHGFLGYVLAGFLLREHHIRVLPAGPRSGFLRFSPSLYITDEEIDRTETALR 506 Query: 434 KTI 436 Sbjct: 507 SLF 509 >4A0G-A nrPDB Length = 831 Score = 194 bits (492), Expect = 9e-50, Method: Composition-based stats. Identities = 81/448 (18%), Positives = 143/448 (31%), Gaps = 91/448 (20%) Query: 80 DFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFN------- 132 D +S+ QG + + + E +L Sbjct: 384 DACASWWT--QGPDPTFQAELAREMGYTAARFGHVMFPENVYEPALKCAELLLDGVGKGW 441 Query: 133 YHKVLPMNTGVEAGETACKLA-RKWGYTVKGIQKYKA------KIVFAAGNFWGRTLSAI 185 +V + G A E A K+A RK+ + + K++ G++ G TL A+ Sbjct: 442 ASRVYFSDNGSTAIEIALKMAFRKFCVDHNFCEATEEEKHIVVKVIALRGSYHGDTLGAM 501 Query: 186 SSSTDPTSY--------------------------------DGFGPFMPGFDIIPYND-- 211 + + F P + D Sbjct: 502 EAQAPSPYTGFLQQPWYTGRGLFLDPPTVFLSNGSWNISLPESFSEIAPEYGTFTSRDEI 561 Query: 212 --------------LPALERALQDP-------NVAAFMVEP-IQGEAGVVVPDPGYLMGV 249 L + LQ+ +V A ++EP I G G+ + DP + + Sbjct: 562 FDKSRDASTLARIYSAYLSKHLQEHSGVRQSAHVGALIIEPVIHGAGGMHMVDPLFQRVL 621 Query: 250 RELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDD 309 C ++ I DE+ TG R G + +PDI K L+GG+ P++ L D Sbjct: 622 VNECRNRKIPVIFDEVFTGFWRLGVETTTELLGCKPDIACFAKLLTGGMVPLAVTLATDA 681 Query: 310 IMLTIKPGE------HGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKL 363 + + HG +Y + +GC A A++ ++ N G LR + Sbjct: 682 VFDSFSGDSKLKALLHGHSYSAHAMGCATAAKAIQWFKDPETNHNITSQGKTLRELWDEE 741 Query: 364 ------PSDVVTAVRGKGLLNAIVIKETKDWD------AWKVCLRLRDNGLLAKPTHGDI 411 V V G L A+ +K A + + LR++G+ +P G++ Sbjct: 742 LVQQISSHSAVQRVVVIGTLFALELKADASNSGYASLYAKSLLIMLREDGIFTRPL-GNV 800 Query: 412 IRFAPPLVIKEDELRESIEIINKTILSF 439 I + R + + K + F Sbjct: 801 IYLMCGPCTSPEICRRLLTKLYKRLGEF 828 >6CBN-A nrPDB Length = 438 Score = 117 bits (294), Expect = 7e-27, Method: Composition-based stats. Identities = 59/286 (20%), Positives = 105/286 (36%), Gaps = 31/286 (10%) Query: 36 GPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHP 95 G T + E+ + P G +L D G ++ DF ++ ++ GH P Sbjct: 21 GHMTKNSSLLAEFPTCPRDEKDRPRVFTAASGAWLTDESGFRWIDFDNARGSILLGHGDP 80 Query: 96 KIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARK 155 V ++ + ++ + E + L V +G A + Sbjct: 81 V-VAEAVARAATGADGTATGWSRRVDAVLERLHALCGGEVVGLFRSGT--------AAVR 131 Query: 156 WGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIP--YNDLP 213 + ++ A + G DP Y P P D + + DL Sbjct: 132 AAVLAVREATGRPLLLSA--GYHG---------YDPMWYPSEAPLEPNADGVVDFFFDLG 180 Query: 214 ALERALQDPN-VAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLART 272 L L+ P VAA +V P + PG+ +R LC+ V+ +ADE++ GL R Sbjct: 181 LLRELLRAPERVAAVVVSPDH-----MHLSPGWYRELRRLCSAAGVVLVADEVKVGL-RY 234 Query: 273 GRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE 318 L+ + PD+ ++ K ++ G + VSAV ++ +K Sbjct: 235 APGLSTAEL-LAPDVWVVAKGMANG-HAVSAVGGSRRLLKPLKEVS 278 >5Z8A-A nrPDB Length = 437 Score = 111 bits (278), Expect = 6e-25, Method: Composition-based stats. Identities = 72/383 (18%), Positives = 122/383 (31%), Gaps = 45/383 (11%) Query: 59 PVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNN 118 P G G YL D +GR++ DF ++ +V GH ++ A+ + ++ Sbjct: 45 PRVFVEGSGAYLTDPDGRRWIDFDNARGSVVLGHGDEEVAEAIARAA-RGRSGVGTAWSP 103 Query: 119 VLGEYEEYITKLFNYHKVLPMNTGVEA---GETACKLARKWGYTVKGIQKYKAKIVFAAG 175 VL + ++ V TG A A + AR + + Sbjct: 104 VLDSLLGQLQEVCGGDVVGLYRTGTAALRSVTCAVRDARDRS-------------IVLSS 150 Query: 176 NFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPY--NDLPALERALQDPN-VAAFMVEPI 232 + G DP + PF P I DL L L P VAA ++ P Sbjct: 151 GYHG---------YDPMWHCD-EPFTPNQHGIVEFLFDLDVLAEWLSRPEQVAAVVISPD 200 Query: 233 QGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGK 292 + + L V IADE++ GL R L+ + P + ++ K Sbjct: 201 H-----MHLGERWYTEFTRLTKEADVPVIADEVKVGL-RYRAGLSTPLLD--PAVWIVAK 252 Query: 293 ALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKL 352 L+ G PV+AV D ++ ++ S + P A L + + Sbjct: 253 CLANG-SPVAAVGGDAHLLAALEDVSFTSYF--EPTAMAAATTTLRRMATGEPQQAIRAA 309 Query: 353 GIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDII 412 G ++ + G N D A GLL Sbjct: 310 GDRFIAHTRAAFANAGVPIDLAGNGNLFQFVCADDEVADAFHAAAAAEGLLFFEGDNQT- 368 Query: 413 RFAPPLVIKEDELRESIEIINKT 435 P ++ + ++ I++ Sbjct: 369 ---PSAAFTDEVVEDACGRIDRV 388 >2BWN-A nrPDB Length = 401 Score = 59.6 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 64/379 (16%), Positives = 114/379 (30%), Gaps = 64/379 (16%) Query: 85 YSAVN--QGHC-HPKIVNALKSQVDKLTLTSRAFYN-----NVLGEYEEYITKLFNYHKV 136 N G HP ++ A+ ++ + S N E I L Sbjct: 50 VWCGNDYLGMGQHPVVLAAMHEALEAVGAGSGGTRNISGTTAYHRRLEAEIAGLHQKEAA 109 Query: 137 LPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDG 196 L ++ A + R + I+++ + I + P Sbjct: 110 LVFSSAYNANDATLSTLRVLFPGL---------IIYSDSLNHASMIEGIKRNAGPKR--- 157 Query: 197 FGPFMPGFDIIPYNDLPALERALQDPNVAA---FMVEPIQGEAGVVVPDPGYLMGVRELC 253 I +ND+ L + + AA E + G P + + ++ Sbjct: 158 ---------IFRHNDVAHLRELIAADDPAAPKLIAFESVYSMDGDFGP----IKEICDIA 204 Query: 254 TRHQVLFIADEIQTGLARTGRWLA--VDYENV--RPDIV--LLGKALS--GGLYPVSAVL 305 L DE+ + G A + + + R DI L KA GG SA + Sbjct: 205 EEFGALTYIDEVH-AVGMYGPRGAGVAERDGLMHRIDIFNGTLAKAYGVFGGYIAASARM 263 Query: 306 CDDDIMLTIKPGEHGSTYGGNPLGCRVA----IAALEVLEEENLAENADKLGIILRNELM 361 D + + PG ST P IA L+ E + L + +L+ L Sbjct: 264 V--DAVRSYAPGFIFSTSL--PPAIAAGAQASIAFLKTAEGQKLRDAQQMHAKVLKMRLK 319 Query: 362 KLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPT-------HGDIIRF 414 L ++ G V+ + L D G+ +P + +RF Sbjct: 320 ALGMPIIDH----GSHIVPVVIGDPVHTKAVSDMLLSDYGVYVQPINFPTVPRGTERLRF 375 Query: 415 APPLVIKEDELRESIEIIN 433 P V ++ + ++ Sbjct: 376 TPSPVHDLKQIDGLVHAMD 394 >6HRH-B nrPDB Length = 469 Score = 58.4 bits (140), Expect = 6e-09, Method: Composition-based stats. Identities = 47/284 (16%), Positives = 100/284 (35%), Gaps = 56/284 (19%) Query: 84 SYSAVN--QGHC-HPKIVNALKSQVDKLTLTSRAFYN-----NVLGEYEEYITKLFNYHK 135 S N G HP+++ A + + + + + N E E+ + +L Sbjct: 74 SVWCSNDYLGMSRHPQVLQATQETLQRHGVGAGGTRNISGTSKFHVELEQELAELHQKDS 133 Query: 136 VLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYD 195 L ++ A ++ +T+ I +++ + I +S Sbjct: 134 ALLFSSCFVANDSTL-------FTLAKILPG--CEIYSDAGNHASMIQGIRNSGAAKF-- 182 Query: 196 GFGPFMPGFDIIPYNDLPALERALQD-----PNVAAFMVEPIQGEAGVVVPDPGYLMGVR 250 + +ND L++ L+ P + AF E + G + P L + Sbjct: 183 ----------VFRHNDPDHLKKLLEKSNPKIPKIVAF--ETVHSMDGAICP----LEELC 226 Query: 251 ELCTRHQVLFIADEIQTGLARTGRWLA--VDYENV--RPDIV--LLGKALS--GGLYPVS 302 ++ ++ L DE+ + G A + + + + DI+ LGKA GG Sbjct: 227 DVSHQYGALTFVDEVH-AVGLYGSRGAGIGERDGIMHKIDIISGTLGKAFGCVGGY---- 281 Query: 303 AVLCDDDIMLTIKPGEHG--STYGGNPLGCRVAIAALEVLEEEN 344 + D++ ++ G T P+ A+ ++ +L+ E Sbjct: 282 -IASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEE 324 >1FC4-A nrPDB Length = 401 Score = 56.1 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 59/404 (14%), Positives = 122/404 (30%), Gaps = 67/404 (16%) Query: 60 VALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAF---- 115 + + + +G +F ++ HP ++ A K+ +D + Sbjct: 29 RIITSAQQADITVADGSHVINFCANNYLGLA--NHPDLIAAAKAGMDSHGFGMASVRFIC 86 Query: 116 -YNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAA 174 + E E+ + + ++ +A G + + + I+ A Sbjct: 87 GTQDSHKELEQKLAAFLGMEDAILYSSCFDAN----------GGLFETLLGAEDAIISDA 136 Query: 175 GNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAA-----FMV 229 N + + ND+ LE L++ A Sbjct: 137 LN-HASIIDGVRLCKAKRYRYAN------------NDMQELEARLKEAREAGARHVLIAT 183 Query: 230 EPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQ-TGLARTGRWLAVDYENVRP--D 286 + + GV+ L GV +L ++ L + D+ G + +Y +V D Sbjct: 184 DGVFSMDGVIAN----LKGVCDLADKYDALVMVDDSHAVGFVGENGRGSHEYCDVMGRVD 239 Query: 287 IV--LLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEEN 344 I+ LGKAL G +++ ++ + N L + A+++VLE Sbjct: 240 IITGTLGKALGG--ASGGYTAARKEVVEWLRQRSRPYLFS-NSLAPAIVAASIKVLE--- 293 Query: 345 LAENADKLGIILRNELMKLPSDVVTAVRGKGLLNA------IVIKETKDWDAWKVCLRLR 398 + G LR+ L + G A I + A K L+ Sbjct: 294 ----MVEAGSELRDRLWANARQFREQMSAAGFTLAGADHAIIPVMLGDAVVAQKFARELQ 349 Query: 399 DNGLLAKPTHGDI-------IRFAPPLVIKEDELRESIEIINKT 435 G+ + IR +++ ++E + Sbjct: 350 KEGIYVTGFFYPVVPKGQARIRTQMSAAHTPEQITRAVEAFTRI 393 >1V2E-A nrPDB Length = 381 Score = 55.0 bits (131), Expect = 7e-08, Method: Composition-based stats. Identities = 67/381 (17%), Positives = 122/381 (32%), Gaps = 62/381 (16%) Query: 85 YSAVNQGHC------HPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHK--V 136 AVN G P ++ A++ + + + L E + + F V Sbjct: 25 LGAVNLGQGFPSNPPPPFLLEAVRRALGRQDQYAPPAG---LPALREALAEEFAVEPESV 81 Query: 137 LPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVF--AAGNFWGRTLSAISSSTDPTSY 194 + + EA + + +V + A Sbjct: 82 VVTSGATEA---------LYVLLQSLVGPGDEVVVLEPFFDVYLPDAFLA----GAKARL 128 Query: 195 DGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCT 254 GF + DL ALE+AL A + P+ +V L + L Sbjct: 129 VRLDLTPEGFRL----DLSALEKALTPRTRALLLNTPMNPTG--LVFGERELEAIARLAR 182 Query: 255 RHQVLFIADEIQTGL-----ARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDD 309 H + I+DE+ L R R A + + GK L Y V ++ + Sbjct: 183 AHDLFLISDEVYDELYYGERPRRLREFAPER---TFTVGSAGKRLEATGYRVGWIVGPKE 239 Query: 310 IMLTIKPGEHGSTYGGNPLGCRVAIA-ALEVLEEENLAENADKLGIILRNELMKLPSDVV 368 M + +++ P + +A AL++ E E LR + + Sbjct: 240 FMPRLAGMRQWTSFSA-PTPLQAGVAEALKLARREGFYEA-------LREGYRRRRDLLA 291 Query: 369 TAVRGKGLLNAI------VIKETKDWDAWKVCLRLR-----DNGLLAKPTHGDIIRFAPP 417 +R GL + ++ E WDA+++ R + + D+ RFA Sbjct: 292 GGLRAMGLRVYVPEGTYFLMAELPGWDAFRLVEEARVALIPASAFYLEDPPKDLFRFA-- 349 Query: 418 LVIKEDELRESIEIINKTILS 438 E+EL ++E + + + S Sbjct: 350 FCKTEEELHLALERLGRVVNS 370 >3TQX-A nrPDB Length = 399 Score = 53.8 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 38/206 (18%), Positives = 67/206 (32%), Gaps = 23/206 (11%) Query: 246 LMGVRELCTRHQVLFIADEIQ-TGLARTGRWLAVDYENVRP--DIVL--LGKALSGGLYP 300 L + +L ++ L + D+ G +Y V DI+ LGKAL G Sbjct: 194 LKSICDLADKYNALVMVDDSHAVGFIGENGRGTPEYCGVADRVDILTGTLGKALGG--AS 251 Query: 301 VSAVLCDDDIMLTIKPGEHGSTYGGN--PLGCRVAIAALEVLEEEN--LAENADKLGIIL 356 +I+ ++ + P+ ++ LE+L+ E L + + Sbjct: 252 GGYTSGHKEIIEWLRNRSRPYLFSNTVAPVIVATSLKVLELLKTEGPQLRKQLQENSRYF 311 Query: 357 RNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAK-------PTHG 409 R + KL +V G I + A + L G+ P Sbjct: 312 RAGMEKLGFQLVP-----GNHPIIPVMLGDAQLATNMADHLLQEGIYVVGFSYPVVPMGK 366 Query: 410 DIIRFAPPLVIKEDELRESIEIINKT 435 IR V + +L +IE + Sbjct: 367 ARIRVQMSAVHTQQQLDRAIEAFGQV 392 >1GC4-A nrPDB Length = 385 Score = 53.4 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 45/246 (18%), Positives = 84/246 (34%), Gaps = 18/246 (7%) Query: 201 MPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLF 260 +P +P D + RA+ A + P V L + L H Sbjct: 145 LPEEGFVP--DPERVRRAITPRTKALVVNSPNNPTGAV--YPKEVLEALARLAVEHDFYL 200 Query: 261 IADEIQTGLARTGRWLAVDYENVRPDIVLL----GKALSGGLYPVSAVLCDDDIMLTIKP 316 ++DEI L G + V P+ L KA + + + +++ + Sbjct: 201 VSDEIYEHLLYEGEHFSPGR--VAPEHTLTVNGAAKAFAMTGWRIGYACGPKEVIKAMAS 258 Query: 317 GEHGSTYGGNPLGCRVAIAALEVLEEEN-LAENADKLGIILRNELMK-LPSDVVTAVRGK 374 ST + + + AL E E A + R+ L++ L + + AVR Sbjct: 259 VSRQSTTSPDTIAQWATLEALTNQEASRAFVEMAREAYRRRRDLLLEGLTALGLKAVRPS 318 Query: 375 GLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHG----DIIRFAPPLVIKEDELRESIE 430 G ++ D + RL + G+ P +R + E+ LR+++E Sbjct: 319 GAFYVLMDTSPIAPDEVRAAERLLEAGVAVVPGTDFAAFGHVRLS--YATSEENLRKALE 376 Query: 431 IINKTI 436 + + Sbjct: 377 RFARVL 382 >2DR1-A nrPDB Length = 386 Score = 51.5 bits (122), Expect = 7e-07, Method: Composition-based stats. Identities = 64/374 (17%), Positives = 130/374 (34%), Gaps = 58/374 (15%) Query: 95 PKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHK---VLPMNTGVEAGETACK 151 P+++ +K Q+ + S+ Y V + E + + K +L ++G E + + Sbjct: 33 PEVLEIMKVQM--FSHRSKE-YRKVHMDTVERLREFLEVEKGEVLLVPSSGTGIMEASIR 89 Query: 152 LARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYND 211 G+ K +V G F R + S+ + PG + P + Sbjct: 90 ---------NGVSKGGKVLVTIIGAFGKRYKEVVESNGRKAVVLEYE---PGKAVKPEDL 137 Query: 212 LPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLAR 271 AL + +P+V A + + GV+ P L + ++ H L D + + + Sbjct: 138 DDALRK---NPDVEAVTITYNETSTGVLNP----LPELAKVAKEHDKLVFVDAV-SAMG- 188 Query: 272 TGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKP--------------- 316 G + D + D+V + G+ P A+ + L I Sbjct: 189 -GADIKFDKWGL--DVVFSSSQKAFGVPPGLAIGAFSERFLEIAEKMPERGWYFDIPLYV 245 Query: 317 ---GEHGSTYGGNPLGCRVAI-AALEVLE----EENLAENADKLGIILRNELMKLPSDVV 368 E ST P+ I AL ++E +E E +K ++R + ++ D++ Sbjct: 246 KYLKEKESTPSTPPMPQVFGINVALRIIEKMGGKEKWLEMYEKRAKMVREGVREIGLDIL 305 Query: 369 TAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHG----DIIRFAPPLVIKEDE 424 G + +V +R G +G R +K ++ Sbjct: 306 AEP-GHESPTITAVLTPPGIKGDEVYEAMRKRGFELAKGYGSVKEKTFRIGHMGYMKFED 364 Query: 425 LRESIEIINKTILS 438 ++E ++ + + I Sbjct: 365 IQEMLDNLREVINE 378 >3A2B-A nrPDB Length = 398 Score = 51.5 bits (122), Expect = 8e-07, Method: Composition-based stats. Identities = 59/389 (15%), Positives = 122/389 (31%), Gaps = 62/389 (15%) Query: 73 VEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRA--FYN---NVLGEYEEYI 127 ++GR+ F S+ +I+ A + ++K F N ++ E EE + Sbjct: 40 IDGRRVLMFGSNSYLGLT--TDTRIIKAAQDALEKYGTGCAGSRFLNGTLDIHVELEEKL 97 Query: 128 TKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISS 187 + + +TG ++ + + + Sbjct: 98 SAYVGKEAAILFSTGFQSNLGPL-----------SCLMGRNDYILLDERDHASIIDGSRL 146 Query: 188 STDPTSYDGFGPFMPGFDIIPYNDLPALERALQ--DPNVAAFM-VEPIQGEAGVVVPDPG 244 S G +N++ L L + A + + I G +V Sbjct: 147 SFSKVIKYG------------HNNMEDLRAKLSRLPEDSAKLICTDGIFSMEGDIVN--- 191 Query: 245 YLMGVRELCTRHQVLFIADEIQTGLARTGRWLA--VDYENVRPDI----VLLGKALSGGL 298 L + + + D+ + L G A + + D+ K+L+ Sbjct: 192 -LPELTSIANEFDAAVMVDDAHS-LGVIGHKGAGTASHFGLNDDVDLIMGTFSKSLASLG 249 Query: 299 YPVSAVLCDDDIMLTIKPGEHGSTYGG--NPLGCRVAIAALEVLEEE-NLAENADKLGII 355 V D D++ +K + P + ALE+++ E E K Sbjct: 250 ---GFVAGDADVIDFLKHNARSVMFSASMTPASVASTLKALEIIQNEPEHIEKLWKNTDY 306 Query: 356 LRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKP-------TH 408 + +L+ D+ + + I I+ + + V L+D+G+ P Sbjct: 307 AKAQLLDHGFDLGAT---ESPILPIFIRSNE--KTFWVTKMLQDDGVFVNPVVSPAVPAE 361 Query: 409 GDIIRFAPPLVIKEDELRESIEIINKTIL 437 +IRF+ D++ E+IE + K Sbjct: 362 ESLIRFSLMATHTYDQIDEAIEKMVKVFK 390 >5JAY-A nrPDB Length = 402 Score = 50.3 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 47/300 (15%), Positives = 89/300 (29%), Gaps = 46/300 (15%) Query: 73 VEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNN-----VLGEYEEYI 127 V+GR F S+ HP+++ A+ + S + + E+ + Sbjct: 44 VDGRAIIGFASNDYLGLA--AHPQLIAAIAEGAQRYGAGSGGSHLLGGHSRAHAQLEDDL 101 Query: 128 TKLFNY----HKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLS 183 + + L +TG A + G TL Sbjct: 102 AEFVGGFVENARALYFSTGYMANLATL-----------------TALAGR-----GTTLF 139 Query: 184 AISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQ--DPNVAAFMVEPIQGEAGVVVP 241 + + + DG I P+ D AL L+ D +V + + + G + P Sbjct: 140 SDALNHASLI-DGARLSRADVQIYPHCDTDALSAMLEASDADVKVIVSDTVFSMDGDIAP 198 Query: 242 DPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWL---AVDYENVRPDIVLLGKALSGGL 298 L + EL +H I D+ G G P+++ +G Sbjct: 199 ----LPRLLELAEQHGAWLIVDDAH-GFGVLGPQGRGAIAQAALRSPNLISIGTLDKAAG 253 Query: 299 YPVSAVLCDDDI--MLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIIL 356 + V + + L + + T P A+L ++ E L ++ Sbjct: 254 VSGAFVAAHETVIEWLVQRARPYIFTTASVPAAAHAVSASLRIIGGEEGDARRAHLQQLI 313 >6ONN-A nrPDB Length = 402 Score = 49.6 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 52/315 (16%), Positives = 95/315 (30%), Gaps = 49/315 (15%) Query: 73 VEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNN-----VLGEYEEYI 127 V+GR F S+ HP +V A+ + S + + E+ + Sbjct: 44 VDGRNMIGFASNDYLGLA--AHPLLVAAITEGARRYGAGSGGSHLLGGHSRAHAQLEDDL 101 Query: 128 TKLFNY----HKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLS 183 + + L +TG A + G TL Sbjct: 102 AEFAGGFVDNPRALYFSTGYMANLATL-----------------TALAGR-----GTTLF 139 Query: 184 AISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAA--FMVEPIQGEAGVVVP 241 + S + DG I P+ D AL L+ + A + + + G + P Sbjct: 140 SDSLNHASLI-DGARLSRADIQIYPHADAEALGAMLEASDAAVKLIVSDTVFSMDGDIAP 198 Query: 242 DPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWL---AVDYENVRPDIVLLGKALSGGL 298 L + EL H + D+ G G + P ++++G Sbjct: 199 ----LARLLELAEHHGAWLVVDDAH-GFGVLGPQGRGAVAEAALRSPHLIVVGTLGKAAG 253 Query: 299 YPVSAVLCDDDI--MLTIKPGEHGSTYGGNPLGCRVAIAALEVL---EEENLAENADKLG 353 + V+ + + L + + T P A+L ++ E E+ + L Sbjct: 254 VSGAFVVAHETVIEWLVQRARPYIFTTASVPSAAHAVSASLRIIGGDEGEHRRAHLRSLI 313 Query: 354 IILRNELMKLPSDVV 368 + R+ L P V Sbjct: 314 ALTRDMLKSTPWLPV 328 >4ISY-A nrPDB Length = 404 Score = 48.8 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 49/271 (18%), Positives = 86/271 (31%), Gaps = 32/271 (11%) Query: 94 HPKIVNALKSQVDKLT-----LTSRAFYNNVLGEYEEYITKLFNY--HKVLPMNTGVEAG 146 HP + A+ + + TS + E E I +V+ G E+ Sbjct: 24 HPAAIEAMAAVQRTIGNASSLHTSGRSARRRIEEARELIADKLGARPSEVIFTAGGTESD 83 Query: 147 ETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDI 206 A K + + + ++ +IV S ++ + P + Sbjct: 84 NLAVK---GIYWARRDAEPHRRRIVTTEVEHHAVLDSVNWLVEHEGAHVTWLPTAADGSV 140 Query: 207 IPYNDLPALERALQ-DPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEI 265 AL ALQ +VA V E G ++P + + + V +D I Sbjct: 141 SA----TALREALQSHDDVALVSVMWANNEVGTILP----IAEMSVVAMEFGVPMHSDAI 192 Query: 266 QTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTY-- 323 Q + + + + + GG V A+L D+ T P HG Sbjct: 193 Q-AVGQLPLDFGASGLS----AMSVAGHKFGGPPGVGALLLRRDV--TCVPLMHGGGQER 245 Query: 324 ---GGNP-LGCRVAIAALEVLEEENLAENAD 350 G P + V +A + + L EN+ Sbjct: 246 DIRSGTPDVASAVGMATAAQIAVDGLEENSA 276 >5TXT-B nrPDB Length = 491 Score = 48.8 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 58/316 (18%), Positives = 102/316 (32%), Gaps = 72/316 (22%) Query: 94 HPKIVNALKSQVDK-----LTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGET 148 HP++++A+ +DK + A +N E + L L ++ A + Sbjct: 72 HPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDA 131 Query: 149 ACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIP 208 L QK K ++F+ + I + I Sbjct: 132 VLSL---------LGQKMKDLVIFSDELNHASMIVGIKHANVKKH------------IFK 170 Query: 209 YNDLPALERALQD-----PNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIAD 263 +NDL LE+ LQ P + AF E + AG V + + +L ++ L D Sbjct: 171 HNDLNELEQLLQSYPKSVPKLIAF--ESVYSMAGSVAD----IEKICDLADKYGALTFLD 224 Query: 264 EIQTGLARTGRWLA--VDYENVRP------------------------DIV--LLGKALS 295 E+ + G A ++ + D++ LGK+ Sbjct: 225 EVH-AVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFG 283 Query: 296 --GGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEE-NLAENADKL 352 GG S L D + PG +T P A AA+ +L + K Sbjct: 284 SVGGYVAASRKLI--DWFRSFAPGFIFTTTLP-PSVMAGATAAIRYQRCHIDLRTSQQKH 340 Query: 353 GIILRNELMKLPSDVV 368 + ++ +L V+ Sbjct: 341 TMYVKKAFHELGIPVI 356 >3WY7-A nrPDB Length = 404 Score = 46.5 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 46/232 (19%), Positives = 72/232 (31%), Gaps = 32/232 (13%) Query: 222 PNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYE 281 A + E + G + P L + +C RH L + DE GL G Sbjct: 185 EERAVVVTESVFSADGDLAP----LRDLHAVCRRHGALLLVDEAH-GLGVRGTRGQGLLH 239 Query: 282 NV----RPDI---VLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTY--GGNPLGCRV 332 V PDI L KAL AVL + + + + G P Sbjct: 240 EVGLAGAPDIVMTTTLSKALGSQG---GAVLGPEAVRAHLIDTARSFIFDTGLAPAAVGA 296 Query: 333 AIAALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWK 392 A AAL VL+ E A + + V+AV + + A Sbjct: 297 ASAALRVLDAEPQRARAVLDRAAELATIAGVTEAPVSAV--------VSVILGDPEIAVG 348 Query: 393 VCLRLRDNGLLAK-------PTHGDIIRFAPPLVIKEDELRESIEIINKTIL 437 D G+ P +R A + +DE+ + +++ + Sbjct: 349 AAAACLDRGVRVGCFRPPTVPAGTSRLRLAARASLTDDEMALARQVLTDVLA 400 >3BB8-A nrPDB Length = 437 Score = 46.1 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 29/141 (20%), Positives = 47/141 (33%), Gaps = 16/141 (11%) Query: 123 YEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTL 182 +E+ + + VL +G A A V+ ++ I AAG Sbjct: 67 FEKKLGEYLGVPYVLTTTSGSSANLLALTALTSPKLGVRALKPGDEVITVAAG------- 119 Query: 183 SAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPD 242 ++ +PT +G P DI YN +L A A M+ G Sbjct: 120 --FPTTVNPTIQNGLIPVFVDVDIPTYNVNASLIEAAVSDKTKAIMIAHTLGNLFD---- 173 Query: 243 PGYLMGVRELCTRHQVLFIAD 263 L VR + ++ + I D Sbjct: 174 ---LAEVRRVADKYNLWLIED 191 >2CH1-A nrPDB Length = 396 Score = 44.9 bits (105), Expect = 7e-05, Method: Composition-based stats. Identities = 47/228 (20%), Positives = 75/228 (32%), Gaps = 39/228 (17%) Query: 201 MPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLF 260 + G P++ L L RA++ + +G++ P L GV ++C +H L Sbjct: 122 IEGPPDRPFS-LETLARAIELHQPKCLFLTHGDSSSGLLQP----LEGVGQICHQHDCLL 176 Query: 261 IADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSG--GLYPVSAVLCDDDI-------- 310 I D + + G +D + K L G+ P+S D+ Sbjct: 177 IVDAVAS---LCGVPFYMDKWEIDAVYTGAQKVLGAPPGITPISISPKALDVIRNRRTKS 233 Query: 311 ----MLTI----------KPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKL---G 353 + +P + T N + AL + EE L + Sbjct: 234 KVFYWDLLLLGNYWGCYDEPKRYHHTVASNLIF--ALREALAQIAEEGLENQIKRRIECA 291 Query: 354 IILRNELMKLPSD-VVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDN 400 IL L K+ D V R + L I K D WKV +N Sbjct: 292 QILYEGLGKMGLDIFVKDPRHR-LPTVTGIMIPKGVDWWKVSQYAMNN 338 >2X8U-A nrPDB Length = 412 Score = 41.5 bits (96), Expect = 8e-04, Method: Composition-based stats. Identities = 50/330 (15%), Positives = 99/330 (30%), Gaps = 49/330 (14%) Query: 95 PKIVNALKSQVDK---LTLTSRAFYNNVLGE--YEEYITKLFNYHKVLPMNTGVEAGETA 149 P ++ A K +D+ T SR G E+ + + + + +TG +A Sbjct: 61 PDVIAAGKQALDEFGSGTTGSRVLNGTYQGHKACEDALKEFYGTEHAIVFSTGYQANLGM 120 Query: 150 CKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPY 209 K + + + YDG + Sbjct: 121 I-----------STLAGKGDYIILDADSH------------ASIYDGCWLGDAEIVRFRH 157 Query: 210 NDLPALERALQDPNVAA---FMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQ 266 N + L++ L A ++E + G + P L + + +H + + DE Sbjct: 158 NSVEDLDKRLGRLPAEAGKLVVLEGVYSMMGDIAP----LQEMVAVSKKHGAMILVDEAH 213 Query: 267 TGLARTGRW--LAVDYENVRPD----IVLLGKALSG-GLYPVSAVLCDDDIMLTIKPGEH 319 G+ G + V D + K++ G + VS + + L +P Sbjct: 214 -GMGFFGEHGRGVFEEAGVEADVDFVVGTFSKSVGTVGGFCVSNHPKFEVLRLVCRPY-- 270 Query: 320 GSTYGGNPLGCRVAIAALE-VLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLN 378 T P A ++ ++ + + K L L + + T ++ Sbjct: 271 VFTASLPPSVVATAATSIRKLMHAGDKRAHLWKNSRRLHQGLRDMGYKLGTETAQSAIIA 330 Query: 379 AIVIKETKDWDAWKVCLRLRDNGLLAKPTH 408 I+ T A + L + GL Sbjct: 331 VIL---TDMAQAVALWQGLLEAGLYVNTAR 357 >5HH9-A nrPDB Length = 390 Score = 41.1 bits (95), Expect = 9e-04, Method: Composition-based stats. Identities = 55/344 (15%), Positives = 102/344 (29%), Gaps = 44/344 (12%) Query: 115 FYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAA 174 + + Y +V + + G A Y +Q K + + Sbjct: 60 YEDEARAWAGRYFAVQPG--QVALTGSTTD-GLAAI-------YGGLLVQPGKEILTSSH 109 Query: 175 GNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQG 234 ++ T T F P + +++ + A P + +Q Sbjct: 110 EHYSTYTTLEYRHKRMGTQVREF-PLFKDPHRVSADEILSSIAAQIRPQTRVLGMTWVQS 168 Query: 235 EAGVVVPDPGYLMGVRELCTRHQ----VLFIADEIQTGLARTGRWLA---VDYE------ 281 +GV +P VREL + ++++ D + G A DY Sbjct: 169 GSGVKLPIREIGKLVRELNQKRDEQDRIIYVVDGVH-GFGVEDVSFADFDCDYFIAGTHK 227 Query: 282 --------NVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIK--PGEHGSTYGGNPLGCR 331 V I+ + L L P D T+ G H + L Sbjct: 228 WLFGPRGTGV---IIARSEQLQEHLVPSIPTFSRADNFGTLMTPGGYHAFE---HRLALG 281 Query: 332 VAIAALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAW 391 A L + + +L L+ L + P + L + + D Sbjct: 282 TAFELHLQLGKAEVQARIHQLNAYLKQRLGEHPKVRLVTPTSPELSSGFTFFRVEGRDCE 341 Query: 392 KVCLRLRDNGLLAKPTHGDI---IRFAPPLVIKEDELRESIEII 432 V L + +++ D+ +R AP L+ E E+ +EI+ Sbjct: 342 AVAKHLMAHRVISDAVDRDVGPVVRLAPSLLNDEAEIDRVLEIL 385 >5YHV-A nrPDB Length = 394 Score = 40.3 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 18/106 (16%), Positives = 32/106 (30%), Gaps = 8/106 (7%) Query: 170 IVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIP------YNDLPALERALQDPN 223 ++ F A++S P + IP + + + P Sbjct: 111 LLAFLACFDAGDRVAMASPGYPCYRNILSALGCEVVEIPCGPQTRFQPTAQMLAEIDPPL 170 Query: 224 VAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGL 269 + P V+ P+ L + C V I+DE+ GL Sbjct: 171 RGVVVASPANPTGTVIPPEE--LAAIASWCDASDVRLISDEVYHGL 214 >2YRI-A nrPDB Length = 353 Score = 40.3 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 54/264 (20%), Positives = 92/264 (34%), Gaps = 37/264 (14%) Query: 196 GFGPFMPGFDIIPYNDLPALERALQDPN---VAAFMVEPIQGEAGVVVPDPGYLMGVREL 252 G P + F D A+ RAL+ VA E GV+ P + L Sbjct: 97 GLDPEVLDFPPGEPVDPEAVARALKRRRYRMVALVHGE---TSTGVLNPA----EAIGAL 149 Query: 253 CTRHQVLFIADEIQTGLARTGRW-LAVDYENVRPDIVLLGKALSG--GLYPVSAVLCDD- 308 LF D + T G ++ V K LS GL P++A L Sbjct: 150 AKEAGALFFLDAVTT----LGMLPFSMRAMGVDYAFTGSQKCLSAPPGLAPIAASLEARK 205 Query: 309 ----------DIMLTIKPGEHGSTYGGNPLGCR-VAIAALEVLEEENLAENADKLGIILR 357 D+ + E G + P+ + AL+++ EE +A + + Sbjct: 206 AFTGKRGWYLDLARVAEHWERGGYHHTTPVLLHYALLEALDLVLEEGVAARERRAREVYA 265 Query: 358 NELMKLPSDVVTAV-RGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLA----KPTHGDII 412 L +L + + L +V++ + DA ++ L G+ PT G ++ Sbjct: 266 WVLEELKARGFRPYPKASPLPTVLVVRPPEGVDADRLVRALYAEGVAVAGGIGPTRGQVL 325 Query: 413 RFAPPLVIKEDELRESIEIINKTI 436 R ++ E RE+ + K + Sbjct: 326 RLG---LMGEGARREAYQAFLKAL 346 >3UWC-A nrPDB Length = 374 Score = 39.9 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 28/186 (15%), Positives = 61/186 (32%), Gaps = 30/186 (16%) Query: 105 VDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQ 164 + + T+ L ++E+ L N + + TG +A + K+ Sbjct: 25 LREFIKTADFTLGAELEKFEKRFAALHNAPHAIGVGTGTDALAMSFKM---------LNI 75 Query: 165 KYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNV 224 +++ A F + + + P D ++ D +E A+ D Sbjct: 76 GAGDEVITCANTFIASVGAIVQAGATPVLVDSENGYV--------IDPEKIEAAITDKTK 127 Query: 225 AAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLAR-----TGRWLAVD 279 A + P+ + + + ++ +H + + D QT L R G W Sbjct: 128 A---IMPVHYTGNIAD-----MPALAKIAKKHNLHIVEDACQTILGRINDKFVGSWGQFA 179 Query: 280 YENVRP 285 ++ P Sbjct: 180 CFSLHP 185 >3LWS-A nrPDB Length = 357 Score = 39.9 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 23/182 (12%), Positives = 50/182 (27%), Gaps = 29/182 (15%) Query: 89 NQGHCHPKIV------NALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTG 142 GH + A+ ++ + A ++ +E+ + + +G Sbjct: 16 ISGHGKRNVGVLKTAFAAVADEMASDQYGTGA----IIEPFEQKFADVLGMDDAVFFPSG 71 Query: 143 VEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWG-RTLSAISSSTDPTSYDGFGPFM 201 A + A ++ + + + L + + Sbjct: 72 TMAQQVALRI--------WSDETDNRTV-----AYHPLCHLEIHEQDGLKELHPIETILV 118 Query: 202 PGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFI 261 D L L+ P++A ++E Q E G V P L + C + Sbjct: 119 GAADR-----LMTLDEIKALPDIACLLLELPQREIGGVAPAFSELETISRYCRERGIRLH 173 Query: 262 AD 263 D Sbjct: 174 LD 175 >3WGB-A nrPDB Length = 341 Score = 39.5 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 53/345 (15%), Positives = 108/345 (31%), Gaps = 31/345 (8%) Query: 99 NALKSQVDKLTLTSRAFYNNV-LGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWG 157 +A++ + + + + + E Y L L + +G + A Sbjct: 19 DAMRQCMLHAEVGDDVYGEDPGVNALEAYGADLLGKEAALFVPSGTMSNLLAV---MSHC 75 Query: 158 YTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALER 217 +G A ++ L +++ P DG I +D+ Sbjct: 76 QRGEGAVLGSAAHIYRYEAQGSAVLGSVALQPVPMQADGSLALADVRAAIAPDDVHFTPT 135 Query: 218 ALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIAD-----EIQTGLART 272 L +E V+ YL +REL H + D T Sbjct: 136 RL-------VCLENTH-NGKVLPLP--YLREMRELVDEHGLQLHLDGARLFNAVVASGHT 185 Query: 273 GRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRV 332 R L +++V + L K L PV ++L + GG + Sbjct: 186 VRELVAPFDSVS---ICLSKGLGA---PVGSLLVGSHAFIARARRLRKMVGGGMRQAGIL 239 Query: 333 AIAALEVLEEENL-AENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAW 391 A A L L++ + + + L L LP + + + + + + ++ Sbjct: 240 AQAGLFALQQHVVRLADDHRRARQLAEGLAALPGIRLDLAQVQTNMVFLQLT---SGESA 296 Query: 392 KVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTI 436 + ++ G+L +R L I +D++ E I+ + + Sbjct: 297 PLLAFMKARGILFSGYGE--LRLVTHLQIHDDDIEEVIDAFTEYL 339 >1O4S-A nrPDB Length = 389 Score = 39.2 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 41/234 (17%), Positives = 79/234 (33%), Gaps = 16/234 (6%) Query: 212 LPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLAR 271 L +E L A + P VV +L G+ L + I+DE+ L Sbjct: 164 LEEVEGLLVGKTKAVLINSPNNPTG--VVYRREFLEGLVRLAKKRNFYIISDEVYDSLVY 221 Query: 272 TGRWLA----VDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNP 327 T + + + + I K+ S + V ++ + + + + +T N Sbjct: 222 TDEFTSILDVSEGFDRIVYINGFSKSHSMTGWRVGYLISSEKVATAVSKIQSHTTSCINT 281 Query: 328 LGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKD 387 + A+ ALEV + + + + + L K+ V G A + Sbjct: 282 VAQYAALKALEV-DNSYMVQTFKERKNFVVERLKKMGVKFV-EPEG-----AFYLFFKVR 334 Query: 388 WDAWKVCLRLRDNGLLAKPTHGDIIR---FAPPLVIKEDELRESIEIINKTILS 438 D K C RL + +A ++ + L E+++ I + S Sbjct: 335 GDDVKFCERLLEEKKVALVPGSAFLKPGFVRLSFATSIERLTEALDRIEDFLNS 388 >1VJO-A nrPDB Length = 393 Score = 38.4 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 43/212 (20%), Positives = 67/212 (31%), Gaps = 27/212 (12%) Query: 93 CHPKIVNALK-SQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACK 151 HP ++ A+ S V L A + + Y+ + N + TG A E Sbjct: 45 AHPSVLQAMNVSPVGHLDPAFLALMDEIQS-LLRYVWQTENPLTIAVSGTGTAAMEATI- 102 Query: 152 LARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYND 211 ++ ++ AG ++G L ++ P+ F Sbjct: 103 --------ANAVEPGDVVLIGVAG-YFGNRLVDMAGRYGADVRTISKPWGEVFS------ 147 Query: 212 LPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLAR 271 L L AL+ A + + G P L GV ELC L + D + T L Sbjct: 148 LEELRTALETHRPAILALVHAETSTGARQP----LEGVGELCREFGTLLLVDTV-TSLG- 201 Query: 272 TGRWLAVDYENVRPDIVLLGKALSG--GLYPV 301 G + +D V K L G P Sbjct: 202 -GVPIFLDAWGVDLAYSCSQKGLGCSPGASPF 232 >2OGE-A nrPDB Length = 399 Score = 36.8 bits (84), Expect = 0.018, Method: Composition-based stats. Identities = 39/227 (17%), Positives = 73/227 (32%), Gaps = 38/227 (16%) Query: 94 HPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLA 153 + A+ +D E+ Y + +N+G++A + A + Sbjct: 43 RAETDAAIARVLDSGRYLLGPELEGFEAEFAAYC----ETDHAVGVNSGMDALQLALR-- 96 Query: 154 RKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLP 213 GI +++ + + L+ ++ P P P D P D Sbjct: 97 ------GLGIGPG-DEVIVPSHTYIASWLAVSATGATPV------PVEPHEDH-PTLDPL 142 Query: 214 ALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLART- 272 +E+A+ A P+ P + +REL RH + + D Q AR Sbjct: 143 LVEKAITPRTRALL---PVHLYG---HPAD--MDALRELADRHGLHIVEDAAQAHGARYR 194 Query: 273 ----GRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIK 315 G +V + P GK L + V D ++ ++ Sbjct: 195 GRRIGAGSSVAAFSFYP-----GKNLGCFGDGGAVVTGDPELAERLR 236 >3PJ0-A nrPDB Length = 359 Score = 36.5 bits (83), Expect = 0.022, Method: Composition-based stats. Identities = 32/185 (17%), Positives = 60/185 (32%), Gaps = 27/185 (14%) Query: 82 LSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGE-YEEYITKLFNYHKVLPMN 140 L N G + AL++ D L S + N + E +E I K+ + Sbjct: 17 LGGNGPRNVG----VLTEALQNIDDNLE--SDIYGNGAVIEDFETKIAKILGKQSAVFFP 70 Query: 141 TGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPF 200 +G A + A ++ W + + + I P Sbjct: 71 SGTMAQQIALRI---WADRKEN----------RRVAYHPLSHLEIHEQDGLKELQQITPL 117 Query: 201 MPGF--DIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQV 258 + G ++ +D+ +L V++ ++E Q E G +P L + E C + Sbjct: 118 LLGTANQLLTIDDIKSLREP-----VSSVLIELPQREIGGQLPAFEELEKISEYCHEQGI 172 Query: 259 LFIAD 263 D Sbjct: 173 SLHLD 177 >5XT5-A nrPDB Length = 419 Score = 36.5 bits (83), Expect = 0.026, Method: Composition-based stats. Identities = 38/230 (16%), Positives = 74/230 (32%), Gaps = 44/230 (19%) Query: 246 LMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVL 305 + + ++ + + + D Q+ + +D +++ D L G V + Sbjct: 184 IKEMAKIAHDNGAVIVVDGAQST-----PHMKIDVQDLDCDFFALSSHKMCGPTGVGVLY 238 Query: 306 CDDDIMLTIKPGEHGS-----------TY--------GGNPL-GCRVAI-AALEVLEEEN 344 ++ ++P E G T+ G P+ + + AA++ LEE Sbjct: 239 GKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTPIIAGAIGLGAAIDFLEEIG 298 Query: 345 LAE---NADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNG 401 L E + KL +L V + +V D V L G Sbjct: 299 LDEISRHEHKLAAYALERFRQLDGVTVYGPEER---AGLVTFNLDDVHPHDVATVLDAEG 355 Query: 402 LLAKPTH------------GDIIRFAPPLVIKEDELRESIEIINKTILSF 439 + + H R + L E+E+ + +E + KT F Sbjct: 356 IAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLVEALQKTKEYF 405 >4OBV-D nrPDB Length = 490 Score = 36.5 bits (83), Expect = 0.026, Method: Composition-based stats. Identities = 25/127 (19%), Positives = 40/127 (31%), Gaps = 8/127 (6%) Query: 138 PMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGF 197 ++ G A TA AR T + A I + + S Sbjct: 155 FVSGGSMANITALTAARDNKLTDINLHLGTAYI---SDQTHSSVAKGLRIIGITDSRIRR 211 Query: 198 GPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAG-VVVPDPGYLMGVRELCTRH 256 P F + D LE A++ + ++ + G AG L + LC +H Sbjct: 212 IPTNSHFQM----DTTKLEEAIETDKKSGYIPFVVIGTAGTTNTGSIDPLTEISALCKKH 267 Query: 257 QVLFIAD 263 + F D Sbjct: 268 DMWFHID 274 >5Z0Y-A nrPDB Length = 470 Score = 35.7 bits (81), Expect = 0.041, Method: Composition-based stats. Identities = 30/185 (16%), Positives = 55/185 (29%), Gaps = 41/185 (22%) Query: 246 LMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRP------DIVLLG--KALSGG 297 +RE+ + + D + V P DIV K+L G Sbjct: 203 YKRMREIADKVGAYLVVD--------MAHISGLIAAGVIPSPFEYADIVTTTTHKSLRG- 253 Query: 298 LYPVSAVL------------CDDDIMLTIKPGEHGSTYGGNP--------LGCRVAIAAL 337 P A++ +I ++ + S + G+ A+ Sbjct: 254 --PRGAMIFFRKGVRSVNPKTGKEIYYDLENPINFSVFPGHQGGPHNHTIAALATALKQA 311 Query: 338 EVLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRL 397 E + E K L NE +L +V+ G +V + KD D ++ Sbjct: 312 ATPEFKQYQEQVLKNAKALENEFKRLGYKLVSD--GTDSHMVLVSLKDKDIDGARIETVC 369 Query: 398 RDNGL 402 + + Sbjct: 370 ENINI 374 >4WP0-A nrPDB Length = 472 Score = 35.3 bits (80), Expect = 0.051, Method: Composition-based stats. Identities = 28/116 (24%), Positives = 43/116 (37%), Gaps = 16/116 (13%) Query: 240 VPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVR--PDIV-------LL 290 V L V LC +H V+ I DE+ + + + ++ P + Sbjct: 190 VFSREELELVASLCQQHDVVCITDEVYQWM----VYDGHQHISIASLPGMWERTLTIGSA 245 Query: 291 GKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLA 346 GK S + V VL D IM ++ S + P + A+A E E E L Sbjct: 246 GKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHC-PTQSQAAVA--ESFEREQLL 298 >3FVS-A nrPDB Length = 422 Score = 35.3 bits (80), Expect = 0.051, Method: Composition-based stats. Identities = 28/116 (24%), Positives = 43/116 (37%), Gaps = 16/116 (13%) Query: 240 VPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVR--PDIV-------LL 290 V L V LC +H V+ I DE+ + + + ++ P + Sbjct: 190 VFSREELELVASLCQQHDVVCITDEVYQWM----VYDGHQHISIASLPGMWERTLTIGSA 245 Query: 291 GKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLA 346 GK S + V VL D IM ++ S + P + A+A E E E L Sbjct: 246 GKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHC-PTQSQAAVA--ESFEREQLL 298 >3L8A-A nrPDB Length = 421 Score = 34.5 bits (78), Expect = 0.099, Method: Composition-based stats. Identities = 20/64 (31%), Positives = 32/64 (50%), Gaps = 1/64 (1%) Query: 211 DLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLA 270 D LE+ + D NV +++ G V + L+ + ELC +H V+ ++DEI LA Sbjct: 182 DFEQLEKDIIDNNVKIYLLCSPHNPGGRVWDNDD-LIKIAELCKKHGVILVSDEIHQDLA 240 Query: 271 RTGR 274 G Sbjct: 241 LFGN 244 >4GDY-A nrPDB Length = 439 Score = 34.5 bits (78), Expect = 0.10, Method: Composition-based stats. Identities = 36/220 (16%), Positives = 76/220 (34%), Gaps = 38/220 (17%) Query: 247 MGVRELCTRHQVLFIADE----IQTGLARTGRWLAVDYEN--VRPDIVLLGKALSGGLYP 300 + EL ++ L I D+ +Q R +L++D + +R D K +S GL Sbjct: 214 KEIYELARKYDFLIIEDDPYYFLQFNSGRVPTFLSMDVDGRVIRAD--SFSKIISSGLR- 270 Query: 301 VSAVLCDDDIMLTIKPGEHGSTYGGNPLG----CRVAIAALEVLEEENLAENADKLGIIL 356 + + ++ + ST +P + L EE + D++ Sbjct: 271 IGFLTGPKPLIERVILHIQVSTL--HPSTFNQLMISQL--LHEWGEEGFMAHVDRVIDFY 326 Query: 357 RNELMKLPSDVVTAVRGK--------GLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTH 408 N+ + + + G G+ I +K D + + G+L P Sbjct: 327 SNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKEL-IEEKAVKMGVLMLP-- 383 Query: 409 GDIIRF---AP-PLV------IKEDELRESIEIINKTILS 438 G+ AP P + +++ + +++ + I Sbjct: 384 GNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKE 423 >3NYS-A nrPDB Length = 367 Score = 34.2 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 22/172 (12%), Positives = 52/172 (30%), Gaps = 24/172 (13%) Query: 96 KIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARK 155 +I + + + + ++ + + E E+ + + G +A ++A Sbjct: 13 RIKDKIDAGIQRVLRHGQYILGPEVTELEDRLADFVGAKYCISCANGTDA-LQIVQMALG 71 Query: 156 WGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPAL 215 G + I + ++ + + G P D YN P L Sbjct: 72 VGPGDEVITPGFTYV----------------ATAETVALLGAKPVYVDIDPRTYNLDPQL 115 Query: 216 ERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQT 267 A P A + P+ + + +++ + I D Q+ Sbjct: 116 LEAAITPRTKAII--PVSLYGQCAD-----FDAINAIASKYGIPVIEDAAQS 160 >5VC2-A nrPDB Length = 424 Score = 33.8 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 42/279 (15%), Positives = 84/279 (30%), Gaps = 44/279 (15%) Query: 139 MNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFG 198 ++G +A + K KI+ + G S Y F Sbjct: 100 AHSGSQANNAVY----------HALLKPYDKILGMDLSCGGHLTHGAKVSLTGKHYQSFS 149 Query: 199 PFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGY-LMGVRELCTRHQ 257 + I Y + + ++++ + G RE+ Sbjct: 150 YGVNLDGYIDYEEALKIAQSVKPEIIVC----------GFSAYPREIDFKKFREIADEVG 199 Query: 258 VLFIADEIQTGLARTGRWLAVDYENVRPDIVLLG----KALSGGLYPVSAVLCD--DDIM 311 L + D G + ++ + P ++ K L G P ++ ++I Sbjct: 200 ALLLGDIAHVA----GLVVTNEHAHPFPHCHVVSSTTHKTLRG---PRGGIILTNDEEIA 252 Query: 312 LTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELM----KLPSDV 367 I T GG PL +A A+ +ENL ++++ + L Sbjct: 253 AKIDKAIFPGTQGG-PLMHVIAAKAVG--FKENLKPEFKAYAKLVKSNMQVLAKALKEKN 309 Query: 368 VTAVRGKGLLNAIVIKE--TKDWDAWKVCLRLRDNGLLA 404 V G G N +++ + K + + L + G+ Sbjct: 310 HKLVSG-GTSNHLLLMDFLDKPYSGKDADIALGNAGITV 347 >2YIU-B nrPDB Length = 263 Score = 33.8 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 19/122 (15%), Positives = 42/122 (34%), Gaps = 20/122 (16%) Query: 281 ENVRPDIVLLGKALSGGLYPVS--------AVLCDDDIMLTIKPGE------------HG 320 E + PD+ L+ KA +G P + + I + + H Sbjct: 117 EGMGPDLSLMAKARAGFHGPYGTGLSQLFNGIGGPEYIHAVLTGYDGEEKEEAGAVLYHN 176 Query: 321 STYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAI 380 + + GN + ++ +V E+ D++ + LM + + G ++ I Sbjct: 177 AAFAGNWIQMAAPLSDDQVTYEDGTPATVDQMATDVAAFLMWTAEPKMMDRKQVGFVSVI 236 Query: 381 VI 382 + Sbjct: 237 FL 238 >4BMK-A nrPDB Length = 442 Score = 33.4 bits (75), Expect = 0.19, Method: Composition-based stats. Identities = 41/281 (14%), Positives = 84/281 (29%), Gaps = 44/281 (15%) Query: 95 PKIVNALKSQVDK---LTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACK 151 P ++ A K ++K T SR ++ + TG A Sbjct: 103 PDVIAAGKEALEKFGSGTNGSRMLNGTFHDHM-----EVEQALRDFYGTTG------AIV 151 Query: 152 LARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYND 211 + + + I + G + + + + + YDG +N Sbjct: 152 FSTGYMANLGIIST-----LAGKGEY-----VILDADSHASIYDGCQQGNAEIVRFRHNS 201 Query: 212 LPALERALQ---DPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQT- 267 + L++ L ++E + G + P L + + +H + + DE + Sbjct: 202 VEDLDKRLGRLPKEPAKLVVLEGVYSMLGDIAP----LKEMVAVAKKHGAMVLVDEAHSM 257 Query: 268 GLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCD-----DDIMLTIKPGEHGST 322 G + + + I + S + V + + + L +P T Sbjct: 258 GFFGPNGRGVYEAQGLEGQIDFVVGTFSASVGTVGGFVVSNHPKFEAVRLACRPYI--FT 315 Query: 323 YGGNPLGCRVAIAALEVL-----EEENLAENADKLGIILRN 358 P A ++ L + E L NA L L+ Sbjct: 316 ASLPPSVVATATTSIRKLMTAHEKRERLWSNARALHGGLKA 356 >5WGB-A nrPDB Length = 426 Score = 33.4 bits (75), Expect = 0.20, Method: Composition-based stats. Identities = 31/182 (17%), Positives = 60/182 (32%), Gaps = 27/182 (14%) Query: 95 PKIVNALKSQVDKL-------TLTSRAFYNNVLGEYEEYITKLFNYHK--VLPMNTGVEA 145 P++++A+ + T + + + L ++ + E+ Sbjct: 40 PRVLDAMLPYLINYYGNPHSRTHAYGWESEAAMERARQQVASLIGADPREIIFTSGATES 99 Query: 146 GETACK-LARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGF 204 A K +AR + K + + + L + S + P Sbjct: 100 NNIAIKGVARFYRSRKKHLITTQTE--------HKCVLDSCRSLEAEGFQVTYLPVQKSG 151 Query: 205 DIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADE 264 I DL LE A+Q P+ + V + E GV P + + +C+ +V F D Sbjct: 152 II----DLKELEAAIQ-PDTSLVSVMTVNNEIGVKQP----IAEIGRICSSRKVYFHTDA 202 Query: 265 IQ 266 Q Sbjct: 203 AQ 204 >4HGV-A nrPDB Length = 495 Score = 33.4 bits (75), Expect = 0.22, Method: Composition-based stats. Identities = 33/223 (14%), Positives = 65/223 (29%), Gaps = 38/223 (17%) Query: 11 FAVLSRGVHSSVA-SATSVATKKTVQGPPTSDDIFEREYKYGAHNYH----PLPVALERG 65 F ++R + + ++T T SD + + + N+ P+A+ R Sbjct: 20 FQSMNRMTKAGITMTSTRTETDTFGPIEVASDRYWGAQAQRSLGNFKIGWEKQPLAIVRA 79 Query: 66 KGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEE 125 GI ++ + + G P I +A+ ++ + ++ Sbjct: 80 LGIVKQ----------AAARANMALGRLDPAIGDAIVKAAQEVIDGKLDEHFPLV----- 124 Query: 126 YITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAI 185 V +G ++ A ++ + G K V + Sbjct: 125 ----------VWQTGSGTQSNMNANEVVSNRAIELLGGVMGSKKPV------HPNDHVNM 168 Query: 186 S-SSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAF 227 S SS D L L +AL + V AF Sbjct: 169 SQSSNDTYPTAMHIACAERVIHDLLPALKHLHKAL-EEKVKAF 210 >3KE3-A nrPDB Length = 379 Score = 33.0 bits (74), Expect = 0.25, Method: Composition-based stats. Identities = 50/321 (15%), Positives = 93/321 (28%), Gaps = 54/321 (16%) Query: 106 DKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGV---EAGETACKLARKWGYTVKG 162 L S+AF + T V+ +G EA + G Sbjct: 24 RALNHMSKAFQEVMNDLLSNLKTVYNAEAAVIIPGSGTYGMEAVARQLTIDEDCLIIRNG 83 Query: 163 IQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDP 222 Y+ + G F S + ++ + PF P D+ +++ Sbjct: 84 WFSYRWTQILEKGKF--AKSSTVLTAERTEDTEAPKPFAP-------VDIETAVAKIKED 134 Query: 223 NVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYEN 282 A ++ +G++ Y+ + E L + D I +G WL + Sbjct: 135 KSAIVYAPHVETSSGII-LSEEYIKALSEAVHSVGGLLVIDCIASGC----VWLDMKELG 189 Query: 283 VRPDIVLLG--KALSG----GLYPVSAVLCDD-----------------DIMLTIKPGEH 319 + D+++ K S GL +SA IM + G H Sbjct: 190 I--DVLISAPQKGWSSTPCAGLVMLSAAAIKKVESTESNCFSLDLKQWLTIMRAYENGGH 247 Query: 320 GSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNA 379 + P L + L A ++G + L ++ VR Sbjct: 248 AY-HATMPTDS------LRQFRDAIL--EAKEIGF---DILRDAQWELGNRVRKVLTDKG 295 Query: 380 IVIKETKDWDAWKVCLRLRDN 400 I + ++A V + + Sbjct: 296 IESVAAEGFEAPGVVVSYTER 316 >1I43-A nrPDB Length = 445 Score = 33.0 bits (74), Expect = 0.29, Method: Composition-based stats. Identities = 54/302 (17%), Positives = 84/302 (27%), Gaps = 54/302 (17%) Query: 106 DKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQK 165 + + + N EE I+ L L M +G+ A T LA + Sbjct: 102 RRASFEYGRYGNPTTVVLEEKISALEGAESTLLMASGMCAS-TVMLLA---------LVP 151 Query: 166 YKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVA 225 IV + R + P P D+ ALE AL V Sbjct: 152 AGGHIVTTTDCY--RKTRIFIETILPKMGITATVIDPA-------DVGALELALNQKKVN 202 Query: 226 AFMVEPIQGEAGVVVPDPGYL-----MGVRELCTRHQVLFIADEIQTGLARTGRWLAVDY 280 F E P +L V +LC L D L Sbjct: 203 LFFTES---------PTNPFLRCVDIELVSKLCHEKGALVCID------GTFATPLNQKA 247 Query: 281 ENVRPDIVLLG--KALSGGLYPVSAVL-CDDDIMLTIKPGEHGSTYGGNPLGCRVAIAAL 337 + D+VL K L G ++ + ++ I+ H NP + I + Sbjct: 248 LALGADLVLHSATKFLGGHNDVLAGCISGPLKLVSEIRNLHHILGGALNPNAAYLIIRGM 307 Query: 338 EV--LEEENLAENADKLGIILRN----------ELMKLPSDVVTAVRGKGLLNAIVIKET 385 + L + A ++ IL L P + + G A+ + Sbjct: 308 KTLHLRVQQQNSTALRMAEILEAHPKVRHVYYPGLQSHPEHHIAKKQMTGFGGAVSFEVD 367 Query: 386 KD 387 D Sbjct: 368 GD 369 >1M32-A nrPDB Length = 366 Score = 32.6 bits (73), Expect = 0.37, Method: Composition-based stats. Identities = 42/317 (13%), Positives = 87/317 (27%), Gaps = 64/317 (20%) Query: 122 EYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRT 181 + T Y VL +G A E + ++ + G + R Sbjct: 45 QLTALATASEGYTSVLLQGSGSYAVEAVL---------GSALGPQDKVLIVSNGAYGARM 95 Query: 182 LSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDP----NVAAFMVEPIQGEAG 237 + + D+ A++ L ++A E G Sbjct: 96 VEMAGLMGIAHHAY-------DCGEVARPDVQAIDAILNADPTISHIAMVHSE---TTTG 145 Query: 238 VVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGG 297 ++ P + V L R+ +I D + +A + + ++ G Sbjct: 146 MLNP----IDEVGALAHRYGKTYIVD-AMSSFGGIPMDIAALHIDY---LISSANKCIQG 197 Query: 298 LYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALE---------------VLEE 342 + + V+ + + K H + L +E + Sbjct: 198 VPGFAFVIAREQKLAACK--GHSRSLS---LDLYAQWRCMEDNHGKWRFTSPTHTVLAFA 252 Query: 343 ENLAENADKLGIILR-NELMKLPSDVVTAVRGKGL------------LNAIVIKETKDWD 389 + L E A + G+ R + +V +R G + A E + Sbjct: 253 QALKELAKEGGVAARHQRYQQNQRSLVAGMRALGFNTLLDDELHSPIITAFYSPEDPQYR 312 Query: 390 AWKVCLRLRDNGLLAKP 406 + RL++ G + P Sbjct: 313 FSEFYRRLKEQGFVIYP 329 >2C44-A nrPDB Length = 471 Score = 32.6 bits (73), Expect = 0.38, Method: Composition-based stats. Identities = 34/210 (16%), Positives = 74/210 (35%), Gaps = 20/210 (9%) Query: 61 ALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVL 120 ++ G +L D E + D L+ + ++++ + + + Sbjct: 31 IIKSGMNPFLLDSED-VFIDLLTDSGTG-------AVTQSMQAAMMRGDEAYSGSRSYYA 82 Query: 121 GEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGR 180 E + +F Y +P + G A + + K KG+ ++K+V + F+ Sbjct: 83 --LAESVKNIFGYQYTIPTHQGRGAEQIYIPVLIKKREQEKGLD--RSKMVAFSNYFFDT 138 Query: 181 TLSAISSSTDPT----SYDGFGPFMPGFDIIPYNDLPALERALQD--PNVAAFMVEPIQG 234 T + + F + +D DL LER +++ PN ++V I Sbjct: 139 TQGHSQINGCTVRNVYIKEAFDTGV-RYDFKGNFDLEGLERGIEEVGPNNVPYIVATITS 197 Query: 235 E-AGVVVPDPGYLMGVRELCTRHQVLFIAD 263 AG L + + ++ + + D Sbjct: 198 NSAGGQPVSLANLKAMYSIAKKYDIPVVMD 227 >3DZZ-A nrPDB Length = 391 Score = 32.2 bits (72), Expect = 0.49, Method: Composition-based stats. Identities = 22/105 (20%), Positives = 39/105 (37%), Gaps = 28/105 (26%) Query: 247 MGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLC 306 + ELC +HQVL I+DEI G + D E++ P + Sbjct: 183 KRIAELCAKHQVLLISDEIH------GDLVLTD-EDITPAFTV-------------DWDA 222 Query: 307 DDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADK 351 + ++ I P + T+ AA ++ +L A++ Sbjct: 223 KNWVVSLISPSK---TFN-----LAALHAACAIIPNPDLRARAEE 259 >2GB3-A nrPDB Length = 409 Score = 31.8 bits (71), Expect = 0.54, Method: Composition-based stats. Identities = 53/328 (16%), Positives = 104/328 (31%), Gaps = 50/328 (15%) Query: 134 HKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTS 193 VL N G EA + + G + ++ + A A P + Sbjct: 103 ENVLVTNGGSEAILFSFAVIANPGDEILVLEPFYANYNAFAK--------IAGVKLIPVT 154 Query: 194 YDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELC 253 F IP N LE + + + P VV + + E+ Sbjct: 155 RRMEEGFA-----IPQN----LESFINERTKGIVLSNPCNPTG--VVYGKDEMRYLVEIA 203 Query: 254 TRHQVLFIADEIQTGLARTGRWLAVDYENVRPD----IVLLGKALSGGLYPVSAVLCDDD 309 RH + I DE+ + + G + ++ D I + K S V ++ ++ Sbjct: 204 ERHGLFLIVDEVYSEIVFRGEF--ASALSIESDKVVVIDSVSKKFSACGARVGCLITRNE 261 Query: 310 IM----LTIKPGEHGSTYGGNPL---GCRVAIAALEVLEEENLAENADKLGIILRNELMK 362 + + + G PL V + L+ + + E + + +L + Sbjct: 262 ELISHAMKLAQGRLAP-----PLLEQIGSVGLLNLDDSFFDFVRETYRERVETVLKKLEE 316 Query: 363 LPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNG--LLAKPTHGDIIRFAPPL-- 418 T G + A + E + A + +G + P G P L Sbjct: 317 HGLKRFTKPSGAFYITAELPVEDAEEFARWMLTDFNMDGETTMVAPLRG--FYLTPGLGK 374 Query: 419 -------VIKEDELRESIEIINKTILSF 439 V+++D L +I+++ + + F Sbjct: 375 KEIRIACVLEKDLLSRAIDVLMEGLKMF 402 >3O59-X nrPDB Length = 300 Score = 31.8 bits (71), Expect = 0.60, Method: Composition-based stats. Identities = 13/41 (31%), Positives = 16/41 (39%), Gaps = 5/41 (12%) Query: 239 VVPDPGYLMGVRELCTRHQ----VLFIADEIQTG-LARTGR 274 +V PG +REL + L I DEI G G Sbjct: 57 LVGPPGVAERIRELVKEYGKEIAALKIVDEIIDGKFGDLGS 97 >3I4K-A nrPDB Length = 383 Score = 31.8 bits (71), Expect = 0.66, Method: Composition-based stats. Identities = 29/115 (25%), Positives = 40/115 (34%), Gaps = 25/115 (21%) Query: 231 PIQGEAGV----VVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENV--- 283 PI EAGV L +RE+ R V +ADE W + V Sbjct: 215 PILAEAGVELFEQPTPADDLETLREITRRTNVSVMADE--------SVWTPAEALAVVKA 266 Query: 284 -RPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGE---HGSTYGGNPLGCRVAI 334 D++ L GGL L I + G HG+T P+G ++ Sbjct: 267 QAADVIALKTTKHGGL------LESKKIAAIAEAGGLACHGATSLEGPIGTAASL 315 >2X5D-A nrPDB Length = 412 Score = 31.8 bits (71), Expect = 0.67, Method: Composition-based stats. Identities = 48/287 (16%), Positives = 103/287 (35%), Gaps = 37/287 (12%) Query: 178 WGRTLSAISSSTDPTSYDGF--------GPFMPGFDIIPYNDLP-ALERALQDPNVAAFM 228 G T+ + S Y P +PG D +N+L A+ ++ P + + Sbjct: 122 HGDTILVPNPSYPIHIYGAVIAGAQVRSVPLVPGIDF--FNELERAIRESIPKPRM-MIL 178 Query: 229 VEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFI-----ADEIQTGLARTGRWLAVDYENV 283 P A V + V L ++ V+ + AD + G +++ Sbjct: 179 GFPSNPTAQCVEL--DFFERVVALAKQYDVMVVHDLAYADIVYDGWKAPSIMQVPGAKDI 236 Query: 284 RPDIVLLGKALSGGLYPVSAVLCDDDIMLTIK--PGEHG-STYGGNPLGCRVAIAALEVL 340 + L K+ + + + ++ + +++ + H T+ PL IAALE Sbjct: 237 AVEFFTLSKSYNMAGWRIGFMVGNPELVSALARIKSYHDYGTFT--PLQVAA-IAALEGD 293 Query: 341 EE--ENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLR 398 ++ ++A + +L L + +V + + A + + + + +L Sbjct: 294 QQCVRDIARQYQQRRDVLVKGLREAGW-MVENPKASMYVWAKIPEPYAHLGSLEFAKKLL 352 Query: 399 DN-------GLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILS 438 + G+ D +RFA L+ D LR+++ I + Sbjct: 353 QDAKVSVSPGIGFGDYGDDHVRFA--LIENRDRLRQAVRGIKAMFRA 397 >3B1C-A nrPDB Length = 392 Score = 31.5 bits (70), Expect = 0.68, Method: Composition-based stats. Identities = 16/64 (25%), Positives = 25/64 (39%), Gaps = 7/64 (10%) Query: 237 GVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYEN---VRPDIVLLGKA 293 G V + L + LC +H V+ ++DEI L ++ + V PD Sbjct: 177 GGRVWEREVLEQIGHLCQKHHVILVSDEIHQDL----TLFGHEHVSFNTVSPDFKDFALV 232 Query: 294 LSGG 297 LS Sbjct: 233 LSSA 236 >2GMS-A nrPDB Length = 390 Score = 31.5 bits (70), Expect = 0.71, Method: Composition-based stats. Identities = 25/163 (15%), Positives = 54/163 (33%), Gaps = 20/163 (12%) Query: 102 KSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVK 161 + + + + +YE K F + +++G A + +T K Sbjct: 18 YKAIQSVLDSKMFTMGEYVKQYETQFAKTFGSKYAVMVSSGSTAN---LLMIAALFFTKK 74 Query: 162 GIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYN-DLPALERALQ 220 K +I+ A ++ S++ P G DI N D+ +L+ A+ Sbjct: 75 PRLKKGDEIIVPAVSW--------STTYYPLQQYGLRVKFVDIDINTLNIDIESLKEAVT 126 Query: 221 DPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIAD 263 D A + + G P + ++ ++ + D Sbjct: 127 DST-KAILTVNLLGN-------PNNFDEINKIIGGRDIILLED 161 >4Q75-A nrPDB Length = 429 Score = 31.5 bits (70), Expect = 0.72, Method: Composition-based stats. Identities = 23/145 (15%), Positives = 44/145 (30%), Gaps = 10/145 (6%) Query: 269 LARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPL 328 TG ++ + + L GG L E G+ G + Sbjct: 243 CGPTGIGFLYGKSDL---LHSMPPFLGGGEMISDVFLDHSTYAEPPSRFEAGTPAIGEAI 299 Query: 329 GCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVR-----GKGLLNAIVIK 383 A+ L + + E ++G L +L LP + R +G L + ++ Sbjct: 300 ALGAAVDYLSGIGMPKIHEYEVEIGKYLYEKLSSLPDVRIYGPRPSESVHRGALCSFNVE 359 Query: 384 ETKDWDAWKVCLRLRDNGLLAKPTH 408 D + +G+ + H Sbjct: 360 GLHPTDLATFLD--QQHGVAIRSGH 382 >1F1U-A nrPDB Length = 323 Score = 31.5 bits (70), Expect = 0.86, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 17/36 (47%) Query: 251 ELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPD 286 ++C + L I+D I+ G R G A + PD Sbjct: 227 QICDKMGALRISDRIERGPGRHGVSNAFYLYILDPD 262 >3B46-A nrPDB Length = 447 Score = 31.1 bits (69), Expect = 0.91, Method: Composition-based stats. Identities = 14/55 (25%), Positives = 23/55 (41%), Gaps = 2/55 (3%) Query: 211 DLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEI 265 D E+A+ A + P G V L + +C +H V+ I+DE+ Sbjct: 190 DFEQFEKAITSKTKAVIINTP-HNPIGKVFTREE-LTTLGNICVKHNVVIISDEV 242 >4GHC-A nrPDB Length = 365 Score = 31.1 bits (69), Expect = 0.96, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 17/36 (47%) Query: 251 ELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPD 286 ++C + L I+D I+ G R G A + PD Sbjct: 227 QICDKMGALRISDRIERGPGRHGVSNAFYLFILDPD 262 >1E19-A nrPDB Length = 314 Score = 31.1 bits (69), Expect = 0.96, Method: Composition-based stats. Identities = 12/80 (15%), Positives = 34/80 (42%), Gaps = 4/80 (5%) Query: 358 NELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPP 417 L + +V G+G + + K + +L + G++ + G + P Sbjct: 143 KRLAREKGWIVKEDSGRGWRRVVPSPDPKGHVEAETIKKLVERGVIVIASGGGGV----P 198 Query: 418 LVIKEDELRESIEIINKTIL 437 +++++ E++ +I+K + Sbjct: 199 VILEDGEIKGVEAVIDKDLA 218 >3IF2-A nrPDB Length = 444 Score = 31.1 bits (69), Expect = 0.98, Method: Composition-based stats. Identities = 16/82 (19%), Positives = 29/82 (35%), Gaps = 15/82 (18%) Query: 195 DGFGPFMPGFDIIPYN----------DLPALE--RALQDPNVAAFMVE-PIQGEAGVVVP 241 F +P D + ++ D ALE AL++ + A P V+ Sbjct: 166 QHFAAVLPHIDEVTHDGEEGFFKYRVDFEALENLPALKEGRIGAICCSRPTNPTGNVL-- 223 Query: 242 DPGYLMGVRELCTRHQVLFIAD 263 + + E+ R+ + I D Sbjct: 224 TDEEMAHLAEIAKRYDIPLIID 245 >4CVQ-A nrPDB Length = 431 Score = 31.1 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 12/57 (21%), Positives = 22/57 (38%), Gaps = 2/57 (3%) Query: 209 YNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEI 265 + DL + + ++ P V LM + E+ +H ++ ADEI Sbjct: 181 FPDLDDIRAKITPRTRGIVIINPNNPTGAV--YSKELLMEIVEIARQHNLIIFADEI 235 >3MAF-B nrPDB Length = 518 Score = 31.1 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 61/335 (18%), Positives = 101/335 (30%), Gaps = 69/335 (20%) Query: 139 MNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFG 198 + G E+ A K R W KGI +A + +SA ++ Y G Sbjct: 170 TSGGTESLLLAMKTYRDWARATKGITAPEAVV----------PVSAHAAFDKAAQYFGIK 219 Query: 199 PFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEA-----GVVVPDPGYLMGVRELC 253 D D+ A+ A+ V + G A GVV P + + L Sbjct: 220 LVRTPLDADYRADVAAMREAITPNTV------VVAGSAPGYPHGVVDP----IPEIAALA 269 Query: 254 TRHQVLFIADEIQTGLA-----RTG---RWLAVDYENVRPDIVLLGKALSGGLYPVSAVL 305 H + D G R G E V K G S +L Sbjct: 270 AEHGIGCHVDACLGGFILPWAERLGYPVPPFDFRLEGVTSVSADTHKY-GYGAKGTSVIL 328 Query: 306 CDDDIMLTIK-------PGEH--GSTYGGN-PLG-CRVAIAALEVLEEENLAENADKL-- 352 +L + PG T+ G+ P A AA+ L EE + ++ Sbjct: 329 YRRPDLLHYQYFIAADWPGGLYFSPTFAGSRPGALSATAWAAMLSLGEEGYLDATRRILQ 388 Query: 353 -GIILRNELMKLPS-DVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGD 410 L+ + +PS ++ L I + + + ++V + G H Sbjct: 389 AADRLKAGVRAIPSLKILGDP-----LWVIAVASD-ELNIYQVMEEMAGRGWRLNGLH-- 440 Query: 411 IIRFAPP-----LVIKEDE---LRESIEIINKTIL 437 PP L ++ E + + + + Sbjct: 441 ----RPPAFHVALTLRHTEPGVVDRFLADLQDAVA 471 >1O69-A nrPDB Length = 394 Score = 31.1 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 32/204 (15%), Positives = 63/204 (30%), Gaps = 32/204 (15%) Query: 106 DKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQK 165 ++L F +N + E++ + K + E A A + + Sbjct: 13 NELKYIEEVFKSNYIAPLGEFVNRFEQSVKDY---SKSE-NALALNSATAALHLALRVAG 68 Query: 166 YKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQD--PN 223 K + A +F +S P Y P D D+ L+ A+++ Sbjct: 69 VKQDDIVLASSF------TFIASVAPICYLKAKPVFIDCDETYNIDVDLLKLAIKECEKK 122 Query: 224 VAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIAD--EIQTGL------ARTGRW 275 A ++ + G A + + E+C + ++ I D E G + Sbjct: 123 PKALILTHLYGNAAK-------MDEIVEICKENDIVLIEDAAEALGSFYKNKALGTFGEF 175 Query: 276 LAVDYENVRPDIVLLGKALSGGLY 299 Y + I+ GG+ Sbjct: 176 GVYSYNGNK--IITTS---GGGML 194 >5W1B-A nrPDB Length = 467 Score = 30.7 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 28/150 (18%), Positives = 49/150 (32%), Gaps = 16/150 (10%) Query: 123 YEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTL 182 ++ +LFNY ++P + G A + K+ ++ KAK NF T Sbjct: 81 LKDKAKELFNYDYIIPAHQGRGAENILFPVLLKY-----KQKEGKAKNPVFISNFHFDT- 134 Query: 183 SAISSSTDPTSYDGFGPFMPGFDIIPYND------LPALERAL---QDPNVAAFMVEPIQ 233 + FD Y+D + L+ + N+ A + Sbjct: 135 -TAAHVELNGCKAINIVTEKAFDSETYDDWKGDFDIKKLKENIAQHGADNIVAIVSTVTC 193 Query: 234 GEAGVVVPDPGYLMGVRELCTRHQVLFIAD 263 AG L V E+ +H + + D Sbjct: 194 NSAGGQPVSMSNLKEVYEIAKQHGIFVVMD 223 >5JD3-A nrPDB Length = 238 Score = 30.7 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 32/199 (16%), Positives = 60/199 (30%), Gaps = 30/199 (15%) Query: 81 FLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMN 140 F + V G I +A + + A + + ++ F ++ +N Sbjct: 24 FAAGSKLVIIG---DSITDAGRDKGIGGEGLFNAHGSGYVALLNAHLFARFPERRLRLVN 80 Query: 141 TGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPF 200 G T LA +W V G++ A+ + P Sbjct: 81 QGNSGN-TVRDLAARWQNDVFGLKPD---------------YVAMMIGINDVWRQFDLPL 124 Query: 201 MPGFDIIPYNDLPALERALQ--DPNVAAFM------VEPIQGEAGVVVPDPGYLMGVREL 252 M + P L+ + P V + +EP + E + Y +R + Sbjct: 125 MTDRHVCPEEYEKTLDELVARTAPTVKGMILLTPYFIEPNR-EDAMRARMDVYGDLMRRV 183 Query: 253 CTRHQVLFIADEIQTGLAR 271 RH L + ++Q R Sbjct: 184 AERHGCLLV--DVQGAFDR 200 >4Q6R-A nrPDB Length = 511 Score = 30.3 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 25/131 (19%), Positives = 40/131 (30%), Gaps = 16/131 (12%) Query: 139 MNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFG 198 + G E+ ACK R + + A + A S Sbjct: 150 TSGGTESILMACKAYRDLAFEKGIKTPE----IVAPQSAHAAFNKAASYFGMKIVRVPLT 205 Query: 199 PFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQV 258 M D+ A+ RA+ N A + Q GV+ P P V +L ++++ Sbjct: 206 KMME-------VDVRAMRRAISR-NTAMLVCSTPQFPHGVIDPVPE----VAKLAVKYKI 253 Query: 259 LFIADEIQTGL 269 D G Sbjct: 254 PLHVDACLGGF 264 >1YIY-A nrPDB Length = 429 Score = 30.3 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 32/215 (14%), Positives = 58/215 (26%), Gaps = 46/215 (21%) Query: 77 KYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKV 136 +Y + Y +N G P K L + A N T+ F + ++ Sbjct: 29 EYIQLAAQYKPLNLGQGFPD------YHAPKYALNALAAAANSPDPLANQYTRGFGHPRL 82 Query: 137 LPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNF-------WGRTLSAISSST 189 + + + + V +++ G + G Sbjct: 83 VQALS------------KLYSQLVDRTINPMTEVLVTVGAYEALYATIQGHVDEGDEVII 130 Query: 190 DPTSYDGFGPFMPGFDIIPYN-------------------DLPALERALQDPNVAAFMVE 230 +D + P + IP D LE + + Sbjct: 131 IEPFFDCYEPMVKAAGGIPRFIPLKPNKTGGTISSADWVLDNNELEALFNEKTKMIIINT 190 Query: 231 PIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEI 265 P G V+ L V LC + VL ++DE+ Sbjct: 191 P-HNPLGKVMDRAE-LEVVANLCKKWNVLCVSDEV 223 >5WT2-A nrPDB Length = 401 Score = 30.3 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 54/357 (15%), Positives = 106/357 (29%), Gaps = 63/357 (17%) Query: 117 NNVLGEYEEYITKLFN---YHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFA 173 + + E + + K N V+ + E+ K Y + ++K K IV Sbjct: 45 HPAIAEALDKLYKGINARDIDDVIITSCATESNNWVLKGV----YFDECLKKGKNHIVTT 100 Query: 174 AGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYND-----LPALERALQDPNVAAFM 228 + + + G +P N+ + A+ + A Sbjct: 101 VAEH-------PAVRSTCNFLESLG---VEVTYLPINEHGSITAEQVREAITEKT-ALVS 149 Query: 229 VEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIV 288 V E G++ P + + +C VLF D +Q + + VD D + Sbjct: 150 VMWANNETGLIFP----IEEIGAICKEKGVLFHTDAVQ-AIGKI----PVDVLKANADFL 200 Query: 289 LLG-------KALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYG-----GNPLGCRVAIAA 336 K + G L G T G ++A+ Sbjct: 201 SFSAHKFHGPKGIGGLYIRSGVGLTPLFHGGEHMNGRRSGTLNVPYIVGMGEAMKLAVEH 260 Query: 337 LEVLEEENLAENADKLGIILRN---------ELMKLPSDVVTAVRGK---GLLNAIVIKE 384 L+ E+E + + DKL L + ++P+ + +VRG +L + Sbjct: 261 LDY-EKEVVGKLRDKLEEALLKIPDVMVVGDRIHRVPNTTLVSVRGIEGEAMLWDLNRSN 319 Query: 385 TKDWDAWKVCLRLRDNGLLAKPTHGD------IIRFAPPLVIKEDELRESIEIINKT 435 + + IR + E E+ ++IE+ ++ Sbjct: 320 IAASTGSACASEDLEANPVMVAIGASKELAHTAIRLSLSRFNTEAEIDKTIEVFSQA 376 >2HUU-A nrPDB Length = 393 Score = 30.3 bits (67), Expect = 1.6, Method: Composition-based stats. Identities = 42/228 (18%), Positives = 70/228 (30%), Gaps = 43/228 (18%) Query: 246 LMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSG--GLYPVS- 302 L GV LC +H L I D + + L G + +D + K L G+ PVS Sbjct: 163 LEGVGALCHQHNCLLIVDTVAS-LG--GAPMFMDRWEIDAMYTGSQKVLGAPPGITPVSF 219 Query: 303 ---AVLCDDDIMLTIKPGEHGSTYGGNPLGC---------------------RVAIAALE 338 AV +K + G+ GC +A+A E Sbjct: 220 SHRAVERYKRRNTKVKVYYWDMSLVGDYWGCFGRPRIYHHTISSTLLYGLREAIAMACEE 279 Query: 339 VLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLR 398 L L + L L ++ + + L IK + D K Sbjct: 280 GL--PALIARHEDCAKRLYRGLQDAGFELYADPKDR-LSTVTTIKVPQGVDWLKAAQYAM 336 Query: 399 DNGLL-----AKPTHGDIIRFAPPL---VIKEDELRESIEIINKTILS 438 L+ PT G + R L + + +++ + + + Sbjct: 337 KTYLVEISGGLGPTAGQVFRIG--LMGQNATTERVDRVLQVFQEAVAA 382 >4H6W-A nrPDB Length = 306 Score = 30.3 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 18/92 (19%), Positives = 30/92 (32%), Gaps = 7/92 (7%) Query: 178 WGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYND-------LPALERALQDPNVAAFMVE 230 G +++I + G P G + + D L Q N A ++ Sbjct: 64 HGTHVASIIFGQHDSPVTGIAPQCRGLIVPVFADESLKLSQLDLSRAIEQAVNNGANIIN 123 Query: 231 PIQGEAGVVVPDPGYLMGVRELCTRHQVLFIA 262 G+ +L +LC + VL IA Sbjct: 124 VSAGQLTDAGEADTWLEKAIQLCQENNVLLIA 155 >5K8B-A nrPDB Length = 403 Score = 30.3 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 23/181 (12%), Positives = 56/181 (30%), Gaps = 31/181 (17%) Query: 246 LMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLG----KALSGGLYPV 301 + ++ +C +H ++ + D Q G D+ K ++ G Sbjct: 140 MDEIKAICKKHNLVLLEDACQA----IGGSYKGQALGTIGDVGCYSFDSVKTITCGE--G 193 Query: 302 SAVLCDD-DIMLTIKPGE-HGSTYGG-------NPL----------GCRVAIAALEVLEE 342 AV+ ++ +I HG + G +P+ + +A L L+ Sbjct: 194 GAVITNNTEIYDNAHMFSDHGHDHIGKDRGAESHPIMGLNFRISEMNAALGLAQLRKLDT 253 Query: 343 ENLAENADKLG-IILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNG 401 + +K + ++ + G + + ++ +L NG Sbjct: 254 IIDIQRKNKKAIKDAMASIPEVSFREIPDPEGDSA-GFLSFMLPTEARTQEISKKLAANG 312 Query: 402 L 402 + Sbjct: 313 V 313 >4EXQ-A nrPDB Length = 368 Score = 29.9 bits (66), Expect = 2.1, Method: Composition-based stats. Identities = 17/91 (18%), Positives = 31/91 (34%), Gaps = 3/91 (3%) Query: 53 HNYHPLP-VALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLT 111 H+ +P +A +G G++L D+ D + VN G ++ + Q L T Sbjct: 248 HDGARVPAIAFTKGGGLWLEDLAATG-VDAVGLDWTVNLGRARERVAGRVALQ-GNLDPT 305 Query: 112 SRAFYNNVLGEYEEYITKLFNYHKVLPMNTG 142 + + + H N G Sbjct: 306 ILFAPPEAIRAEARAVLDSYGNHPGHVFNLG 336 >3RI6-A nrPDB Length = 430 Score = 29.9 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 34/163 (20%), Positives = 54/163 (33%), Gaps = 26/163 (15%) Query: 106 DKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETAC-KLARKWGYTVKGIQ 164 L N + + E+ + L VL + +G+ A TA LAR Sbjct: 70 RALGHVYSRSSNPTVEDLEQRLKNLTGALGVLALGSGMAAISTAILTLARA--------- 120 Query: 165 KYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNV 224 +V F G TLS + FG + D++ D A+E A D Sbjct: 121 --GDSVVTTDRLF-GHTLSLFQKT-----LPSFGIEVRFVDVM---DSLAVEHAC-DETT 168 Query: 225 AAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQT 267 +E I + V D L + ++ + + D T Sbjct: 169 KLLFLETI-SNPQLQVAD---LEALSKVVHAKGIPLVVDTTMT 207 >4CO7-A nrPDB Length = 119 Score = 29.9 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 8/24 (33%), Positives = 14/24 (58%) Query: 56 HPLPVALERGKGIYLWDVEGRKYF 79 +PV +E+ G + D++ RKY Sbjct: 29 DRVPVIVEKVSGSQIVDIDKRKYL 52 >1YFM-A nrPDB Length = 488 Score = 29.9 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 13/115 (11%), Positives = 35/115 (30%), Gaps = 25/115 (21%) Query: 57 PLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFY 116 +P+ L G+ ++ + G PKI A++ D++ + Sbjct: 65 RMPLPLVHAFGV----------LKKSAAIVNESLGGLDPKISKAIQQAADEVASGKLDDH 114 Query: 117 NNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIV 171 ++ V +G ++ A ++ + G + ++ Sbjct: 115 FPLV---------------VFQTGSGTQSNMNANEVISNRAIEILGGKIGSKQVH 154 >3KGX-A nrPDB Length = 393 Score = 29.5 bits (65), Expect = 2.6, Method: Composition-based stats. Identities = 17/58 (29%), Positives = 26/58 (44%), Gaps = 8/58 (13%) Query: 212 LPALERALQDPNVAAFMVEPIQGEA--GVVVPDPGYLMGVRELCTRHQVLFIADEIQT 267 L +E L + + GE+ GVV P G+ ELC R+Q L + D + + Sbjct: 137 LQEVEEGLAQHKPVLLFL--VHGESSTGVVQPLDGF----GELCHRYQCLLLVDSVAS 188 >3VK2-A nrPDB Length = 398 Score = 29.5 bits (65), Expect = 2.9, Method: Composition-based stats. Identities = 24/125 (19%), Positives = 42/125 (33%), Gaps = 14/125 (11%) Query: 194 YDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELC 253 + G G F + DL ALE A+ + P + + D + GV ++ Sbjct: 122 HHGIGEFGVKLRHVDMADLQALEAAMTPATRVIYFESP--ANPNMHMAD---IAGVAKIA 176 Query: 254 TRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLG--KALSG-GLYPVSAVLCDDDI 310 +H + D + D+V+ K LSG G V+ + Sbjct: 177 RKHGATVVVDNTYC------TPYLQRPLELGADLVVHSATKYLSGHGDITAGIVVGSQAL 230 Query: 311 MLTIK 315 + I+ Sbjct: 231 VDRIR 235 >1GDE-A nrPDB Length = 389 Score = 29.5 bits (65), Expect = 3.3, Method: Composition-based stats. Identities = 10/55 (18%), Positives = 23/55 (41%), Gaps = 2/55 (3%) Query: 211 DLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEI 265 ++ L++ + D A + P V+ L + + H ++ I+DE+ Sbjct: 149 NVDELKKYVTDKTRALIINSPCNPTGAVLTKKD--LEEIADFVVEHDLIVISDEV 201 >5VKU-h nrPDB Length = 306 Score = 29.5 bits (65), Expect = 3.3, Method: Composition-based stats. Identities = 16/73 (21%), Positives = 28/73 (38%), Gaps = 8/73 (10%) Query: 354 IILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLL--AKPTH--- 408 + L + VR +GLL + + + + ++ L + +GLL T Sbjct: 42 KHYQLGLHQFVDHTRGYVRLRGLLRNMTLTLMRRVEGNQILLHVPTHGLLYTVLNTGPVT 101 Query: 409 ---GDIIRFAPPL 418 GD + PPL Sbjct: 102 WEKGDALCVLPPL 114 >1WZC-A nrPDB Length = 249 Score = 29.1 bits (64), Expect = 3.4, Method: Composition-based stats. Identities = 29/158 (18%), Positives = 52/158 (32%), Gaps = 23/158 (14%) Query: 66 KGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKL-TLTSRAFYNNVLGEYE 124 KG + +DV+G++ + +Y + G V ++ ++ KL + +Y N E Sbjct: 72 KGYFPFDVKGKE----VGNYIVIELGIR----VEKIREELKKLENIYGLKYYGNSTKEEI 123 Query: 125 EYITKLFN------YHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFW 178 E T + + E ET + +R V +K + Sbjct: 124 EKFTGMPPELVPLAMER--------EYSETIFEWSRDGWEEVLVEGGFKVTMGSRFYTVH 175 Query: 179 GRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALE 216 G + ++ Y G YND P E Sbjct: 176 GNSDKGKAAKILLDFYKRLGQIESYAVGDSYNDFPMFE 213 >3V4G-A nrPDB Length = 180 Score = 29.1 bits (64), Expect = 3.5, Method: Composition-based stats. Identities = 14/55 (25%), Positives = 23/55 (41%), Gaps = 4/55 (7%) Query: 379 AIVIKETKDWDAWKVCLRL----RDNGLLAKPTHGDIIRFAPPLVIKEDELRESI 429 A+V+ T A + L + G+L D I P L I ++L +S+ Sbjct: 118 ALVVIHTGPGAAQLIARMLDSLGKSEGILGVVAGDDTIFITPTLTITTEQLFKSV 172 >6ACF-A nrPDB Length = 367 Score = 29.1 bits (64), Expect = 3.6, Method: Composition-based stats. Identities = 11/51 (21%), Positives = 18/51 (35%), Gaps = 4/51 (7%) Query: 126 YITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKG----IQKYKAKIVF 172 + ++ N+ EA E A +LAR Y + K I+ Sbjct: 35 TLGPALGGTRMWMYNSEEEALEDALRLARGMTYKNAAAGLNLGGGKTVIIG 85 >3ZXX-A nrPDB Length = 307 Score = 29.1 bits (64), Expect = 3.7, Method: Composition-based stats. Identities = 20/92 (21%), Positives = 33/92 (35%), Gaps = 7/92 (7%) Query: 178 WGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYND-------LPALERALQDPNVAAFMVE 230 G +++I TS G P G + ++D L + N A ++ Sbjct: 70 HGTHVASIIFGQPETSVPGIAPQCRGLIVPIFSDDRRRITQLDLARGIERAVNAGAHIIN 129 Query: 231 PIQGEAGVVVPDPGYLMGVRELCTRHQVLFIA 262 GE G+L LC ++ VL +A Sbjct: 130 ISGGELTDFGEADGWLENAVSLCRQNNVLLVA 161 >4W8Y-A nrPDB Length = 888 Score = 29.1 bits (64), Expect = 3.7, Method: Composition-based stats. Identities = 10/54 (18%), Positives = 22/54 (40%), Gaps = 8/54 (14%) Query: 386 KDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF 439 ++ +V ++D GLL D++ P + +++E+ K F Sbjct: 667 ANFSIREVRSVVKDEGLLIYAGGDDVLAILP--------VDKALEVAYKIRKEF 712 >2ZJG-A nrPDB Length = 410 Score = 29.1 bits (64), Expect = 3.9, Method: Composition-based stats. Identities = 42/270 (15%), Positives = 75/270 (27%), Gaps = 45/270 (16%) Query: 77 KYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKV 136 + D ++ Y +G HP +V A L+ Y + EE + + Y + Sbjct: 49 AFIDNMNQY---TRGFGHPALVKA-------LSCLYGKIYQRQIDPNEEILVAVGAYGSL 98 Query: 137 LPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIV--FAAGNFWGRTLSAISSSTDPTSY 194 N+ + I+ + + ++ P Sbjct: 99 F--NS-----------------IQGLVDPGDEVIIMVPFYDCY--EPMVRMA-GAVPVFI 136 Query: 195 DGFGPFMPGFDIIPYN---DLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRE 251 G + D LE A + P V L + + Sbjct: 137 PLRSKPTDGMKWTSSDWTFDPRELESKFSSKTKAIILNTPHNPLGKVYTRQE--LQVIAD 194 Query: 252 LCTRHQVLFIADE-----IQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLC 306 LC +H L I+DE + TG I GK S + + + Sbjct: 195 LCVKHDTLCISDEVYEWLVYTGHTHVKIATLPGMWERTITIGSAGKTFSVTGWKLGWSIG 254 Query: 307 DDDIMLTIKPGEHGSTYG-GNPLGCRVAIA 335 ++ ++ + S Y PL +A A Sbjct: 255 PAHLIKHLQTVQQNSFYTCATPLQAALAEA 284 >2BS2-A nrPDB Length = 660 Score = 29.1 bits (64), Expect = 4.1, Method: Composition-based stats. Identities = 16/76 (21%), Positives = 28/76 (36%), Gaps = 24/76 (31%) Query: 12 AVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPVALE-------- 63 AV+ G +++A T +A ++ +HP P+ Sbjct: 229 AVVCEGTGTAIALETGIAQLGNMEAVQ----------------FHPTPLFPSGILLTEGC 272 Query: 64 RGKGIYLWDVEGRKYF 79 RG G L DV+G ++ Sbjct: 273 RGDGGILRDVDGHRFM 288 >3J9R-A nrPDB Length = 386 Score = 28.8 bits (63), Expect = 4.5, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 25/65 (38%), Gaps = 1/65 (1%) Query: 91 GHC-HPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETA 149 GH + A+ +KL + N E K F ++ ++ GV+ ++A Sbjct: 132 GHSAQQAVATAMDGLAEKLRAIAILDGPNSTDEAAVAYAKNFGSKRLFMVDPGVQVWDSA 191 Query: 150 CKLAR 154 AR Sbjct: 192 TNAAR 196 >2EZ1-A nrPDB Length = 456 Score = 28.8 bits (63), Expect = 4.7, Method: Composition-based stats. Identities = 27/146 (18%), Positives = 43/146 (29%), Gaps = 6/146 (4%) Query: 122 EYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRT 181 E + +LF + ++P + G A +LA K G V G + + Sbjct: 79 HLERTVQELFGFKHIVPTHQGRGAENLLSQLAIKPGQYVAGNMYFTTT------RYHQEK 132 Query: 182 LSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVP 241 A+ G + I L L N+A + AG Sbjct: 133 NGAVFVDIVRDEAHDAGLNIAFKGDIDLKKLQKLIDEKGAENIAYICLAVTVNLAGGQPV 192 Query: 242 DPGYLMGVRELCTRHQVLFIADEIQT 267 + VREL H + D + Sbjct: 193 SMANMRAVRELTEAHGIKVFYDATRC 218 >1NU5-A nrPDB Length = 370 Score = 28.8 bits (63), Expect = 4.8, Method: Composition-based stats. Identities = 36/175 (20%), Positives = 61/175 (34%), Gaps = 21/175 (12%) Query: 221 DPNVAAFMVEPIQGEAGV----VVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWL 276 D A+ + P EAGV +R L ++ V +ADE + L+ + L Sbjct: 200 DEQTASIWI-PRLEEAGVELVEQPVPRANFGALRRLTEQNGVAILADESLSSLS-SAFEL 257 Query: 277 AVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAA 336 A D+ D L GG ++ L + +G T + +G A+ Sbjct: 258 ARDH---AVDAFSLKLCNMGG---IANTLKVAAVAEAAGISSYGGTMLDSTVGTAAALHV 311 Query: 337 LEVLEEENLAENAD-----KLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETK 386 L +L + LG L + +++ V G GL + + K Sbjct: 312 YATL--PSLPYGCELIGPWVLGDRLTQQDLEIKDFEVHLPLGSGL--GVDLDHDK 362 >6J36-A nrPDB Length = 460 Score = 28.8 bits (63), Expect = 5.4, Method: Composition-based stats. Identities = 4/30 (13%), Positives = 10/30 (33%) Query: 283 VRPDIVLLGKALSGGLYPVSAVLCDDDIML 312 ++ D+ L + P A + + Sbjct: 21 IQVDVYTLAGGFGSAIVPSGASTGSREALE 50 >3ISL-A nrPDB Length = 416 Score = 28.8 bits (63), Expect = 5.6, Method: Composition-based stats. Identities = 25/110 (22%), Positives = 39/110 (35%), Gaps = 18/110 (16%) Query: 228 MVEPIQGEA--GVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRP 285 +V + GE G + P L + E C LFI D + T + G + VD + Sbjct: 139 IVAMVHGETSTGRIHP----LKAIGEACRTEDALFIVDAVAT-IG--GCEVKVDEWKIDA 191 Query: 286 DIVLLGKALS--GGLYPVS-------AVLCDDDIMLTIKPGEHGSTYGGN 326 I K LS G+ P++ + + I + GN Sbjct: 192 AIGGTQKCLSVPSGMAPITYNERVADVIAARKKVERGIATQADRAALSGN 241 >3WYD-A nrPDB Length = 228 Score = 28.4 bits (62), Expect = 7.3, Method: Composition-based stats. Identities = 13/51 (25%), Positives = 19/51 (37%), Gaps = 4/51 (7%) Query: 281 ENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCR 331 + PD + + GG S + D+ + P G GNPLG Sbjct: 104 YKIDPDRIYMTGHSMGGYGTWSIAMNHPDVFAALAPVAGG----GNPLGMA 150 >3NNK-A nrPDB Length = 411 Score = 28.0 bits (61), Expect = 8.2, Method: Composition-based stats. Identities = 19/72 (26%), Positives = 29/72 (40%), Gaps = 7/72 (9%) Query: 232 IQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLG 291 +QG+ + P L + E+C R+ LF D + L G L D + + Sbjct: 145 VQGDTSTTMLQP--LAELGEICRRYDALFYTDATAS-LG--GNPLETDVWGLDAVSAGMQ 199 Query: 292 KALSG--GLYPV 301 K L G G P+ Sbjct: 200 KCLGGPSGTSPI 211 >1KNR-A nrPDB Length = 540 Score = 28.0 bits (61), Expect = 8.8, Method: Composition-based stats. Identities = 15/110 (13%), Positives = 39/110 (35%), Gaps = 11/110 (10%) Query: 27 SVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYF---DFLS 83 ++A + + + F Y + L RG+G YL +G ++ D Sbjct: 226 AMAWRAGCRVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERG 285 Query: 84 SYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNY 133 + + A+ ++ +L + + ++ + ++I + F Sbjct: 286 ELAP------RDIVARAIDHEMKRLG--ADCMFLDISHKPADFIRQHFPM 327 >3NL2-A nrPDB Length = 540 Score = 28.0 bits (61), Expect = 9.1, Method: Composition-based stats. Identities = 25/115 (21%), Positives = 43/115 (37%), Gaps = 22/115 (19%) Query: 248 GVRELCTRHQVLFIAD---EIQTGLARTGRWLAVD-------YENVRPDIVLLGKALSGG 297 ++ELC H V I + ++ + G + D + V PD +++G ++ Sbjct: 60 QIKELCHAHNVPLIINDRIDVAMAIGADGIHVGQDDMPIPMIRKLVGPD-MVIGWSVG-- 116 Query: 298 LYPVSAVLCDD---DIMLTIKPGEHGSTYGGN-----PLGCRVAIAALEVLEEEN 344 +P D++ I G T P+G AI L+ LE N Sbjct: 117 -FPEEVDELSKMGPDMVDYIGVGTLFPTLTKKNPKKAPMGTAGAIRVLDALERNN 170 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.313 0.145 0.396 Lambda K H 0.267 0.0448 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,392,482 Number of Sequences: 36641 Number of extensions: 839016 Number of successful extensions: 3628 Number of sequences better than 10.0: 198 Number of HSP's better than 10.0 without gapping: 184 Number of HSP's successfully gapped in prelim test: 103 Number of HSP's that attempted gapping in prelim test: 2695 Number of HSP's gapped (non-prelim): 323 length of query: 439 length of database: 10,336,785 effective HSP length: 100 effective length of query: 339 effective length of database: 6,672,685 effective search space: 2262040215 effective search space used: 2262040215 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 61 (28.0 bits)