BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P00490 (797 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1AHP-A nrPDB 1625 0.0 5OX0-A nrPDB 665 0.0 2ZB2-A nrPDB 657 0.0 5IKP-A nrPDB 649 0.0 4BQE-A nrPDB 635 0.0 2C4M-A nrPDB 633 0.0 1YGP-A nrPDB 603 e-173 4L22-A nrPDB 496 e-140 5LR8-A nrPDB 372 e-103 4BHW-A nrPDB 35 0.11 5XZC-A nrPDB 35 0.11 6HMF-A nrPDB 33 0.48 2HTW-A nrPDB 33 0.48 6HMS-A nrPDB 33 0.52 4B7M-A nrPDB 32 1.1 3TI5-A nrPDB 32 1.3 2HU4-A nrPDB 32 1.4 4V8M-A0 nrPDB 32 1.4 3CYE-A nrPDB 32 1.5 3TQQ-A nrPDB 31 2.0 4AMU-A nrPDB 29 6.4 2F3D-A nrPDB 29 7.3 5NCK-A nrPDB 29 8.3 >1AHP-A nrPDB Length = 797 Score = 1625 bits (4209), Expect = 0.0, Method: Compositional matrix adjust. Identities = 785/797 (98%), Positives = 788/797 (98%) Query: 1 MSQPIFNDKQFQEALSRQWQRYGLNSAAEMTPRQWWLAVSEALAEMLRAQPFAKPVANQR 60 MSQPIFNDKQFQEALSRQWQRYGLNSAAEMTPRQWWLAVSEALAEMLRAQPFAKPVANQR Sbjct: 1 MSQPIFNDKQFQEALSRQWQRYGLNSAAEMTPRQWWLAVSEALAEMLRAQPFAKPVANQR 60 Query: 61 HVNYISMEFLIGRLTGNNLLNLGWYQDVQDSLKAYDINLTDLLEEEIDPALGNGGLGRLA 120 HVNYISMEFLIGRLTGNNLLNLGWYQDVQDSLKAYDINLTDLLEEEIDPALG GGLGRLA Sbjct: 61 HVNYISMEFLIGRLTGNNLLNLGWYQDVQDSLKAYDINLTDLLEEEIDPALGAGGLGRLA 120 Query: 121 ACFLDSMATVGQSATGYGLNYQYGLFRQSFVDGKQVEAPDDWHRSNYPWFRHNEALDVQV 180 ACFLDSMATVGQSATGYGLNYQYGLFRQSFVDGKQVEAPDDWHRSNYPWFRHNEALDVQV Sbjct: 121 ACFLDSMATVGQSATGYGLNYQYGLFRQSFVDGKQVEAPDDWHRSNYPWFRHNEALDVQV 180 Query: 181 GIGGKVTKDGRWEPEFTITGQAWDLPVVGYRNGVAQPLRLWQATHAHPFDLTKFNDGDFL 240 GIGG VTKDGRWEPEFTITGQAWDLPVVGYRNGVAQPLRLWQATHAHPFDLTKFNDGDFL Sbjct: 181 GIGGAVTKDGRWEPEFTITGQAWDLPVVGYRNGVAQPLRLWQATHAHPFDLTKFNDGDFL 240 Query: 241 RAEQQGINAEKLTKVLYPNDNHTAGKKLRLMQQYFQCACSVADILRRHHLAGRKLHELAD 300 RAEQQGINAEKLTKVLYPNDNHTAGKKLRLMQQYFQCACSVADILRRHHLAGR+LHELAD Sbjct: 241 RAEQQGINAEKLTKVLYPNDNHTAGKKLRLMQQYFQCACSVADILRRHHLAGRELHELAD 300 Query: 301 YEVIQLNDTHPTIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKL 360 YEVIQLNDTHPTIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKL Sbjct: 301 YEVIQLNDTHPTIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKL 360 Query: 361 VKGLLPRHMQIINEINTRFKTLVEKTWPGDEKVWAKLAVVHDKQVHMANLCVVGGFAVNG 420 VKGLLPRHMQIINEINTRFKTLVEKTWPGDEKVWAKLAVVHDKQVHMANLCVVGGFAVNG Sbjct: 361 VKGLLPRHMQIINEINTRFKTLVEKTWPGDEKVWAKLAVVHDKQVHMANLCVVGGFAVNG 420 Query: 421 VAALHSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPALAALLDKSLQKEWAND 480 VAALHSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPALAALLDKSLQKEWAND Sbjct: 421 VAALHSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPALAALLDKSLQKEWAND 480 Query: 481 LDQLINLEKFADDAKFRQQYREIKQANKVRLAEFVKVRTGIEINPQAIFDIQIKRLHEYK 540 LDQLINL K ADDAKFR YR IKQANKVRLAEFVKVRTGI+INPQAIFDIQIKRLHEYK Sbjct: 481 LDQLINLVKLADDAKFRDLYRVIKQANKVRLAEFVKVRTGIDINPQAIFDIQIKRLHEYK 540 Query: 541 RQHLNLLHILALYKEIRENPQADRVPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDP 600 RQHLNLL ILALYKEIRENPQADRVPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDP Sbjct: 541 RQHLNLLRILALYKEIRENPQADRVPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDP 600 Query: 601 LVGDKLKVVFLPDYCVSAAEKLIPAADISEQISTAGKEASGTGNMKLALNGALTVGTLDG 660 LVGDKLKVVFLPDYCVSAAEKLIPAADISEQISTAGKEASGTGNMKLALNGALTVGTLDG Sbjct: 601 LVGDKLKVVFLPDYCVSAAEKLIPAADISEQISTAGKEASGTGNMKLALNGALTVGTLDG 660 Query: 661 ANVEIAEKVGEENIFIFGHTVEQVKAILAKGYDPVKWRKKDKVLDAVLKELESGKYSDGD 720 ANVEIAEKVGEENIFIFGHTV+QVKAILAKGYDPVKWRKKDKVLDAVLKELESGKYSDGD Sbjct: 661 ANVEIAEKVGEENIFIFGHTVKQVKAILAKGYDPVKWRKKDKVLDAVLKELESGKYSDGD 720 Query: 721 KHAFDQMLHSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRDQEAWTRAAILNTARCGMFS 780 KHAFDQMLHSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRDQEAWTRAAILNTARCGMFS Sbjct: 721 KHAFDQMLHSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRDQEAWTRAAILNTARCGMFS 780 Query: 781 SDRSIRDYQARIWQAKR 797 SDRSIRDYQARIWQA R Sbjct: 781 SDRSIRDYQARIWQAAR 797 >5OX0-A nrPDB Length = 843 Score = 665 bits (1716), Expect = 0.0, Method: Compositional matrix adjust. Identities = 349/785 (44%), Positives = 497/785 (63%), Gaps = 28/785 (3%) Query: 31 TPRQWWLAVSEALAEMLRAQPFAKPVANQRH--------VNYISMEFLIGRLTGNNLLNL 82 TPR ++ A LA +R + + Q+H + Y+S+EF +GR N ++NL Sbjct: 48 TPRDYYFA----LAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNL 103 Query: 83 GWYQDVQDSLKAYDINLTDLLEEEIDPALGNGGLGRLAACFLDSMATVGQSATGYGLNYQ 142 ++ +++ +L E E D LGNGGLGRLAACFLDSMAT+G +A GYG+ Y+ Sbjct: 104 ALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYE 163 Query: 143 YGLFRQSFVDGKQVEAPDDWHRSNYPWFRHNEALDVQVGIGGKV---TKDGRWEPEFTIT 199 +G+F Q G Q+E DDW R PW + + V G+V ++ +W + Sbjct: 164 FGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVL 223 Query: 200 GQAWDLPVVGYRNGVAQPLRLWQATHAHPFDLTKFNDGDFLRAEQQGINAEKLTKVLYPN 259 +D PV GYRN V +RLW A + F+L FN G +++A AE +++VLYPN Sbjct: 224 AMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPN 283 Query: 260 DNHTAGKKLRLMQQYFQCACSVADILRRHHLAG--------RKLHELADYEVIQLNDTHP 311 DN GK+LRL Q+YF A ++ DI+RR + D IQLNDTHP Sbjct: 284 DNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHP 343 Query: 312 TIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQI 371 ++AIPEL+RVL+D ++ WD AW +T KT AYTNHT++PEALERW V L++ LLPRH+QI Sbjct: 344 SLAIPELMRVLVDLERLDWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQI 403 Query: 372 INEINTRFKTLVEKTWPGDEKVWAKLAVVHD---KQVHMANLCVVGGFAVNGVAALHSDL 428 I EIN RF V +PGD ++++V + K+++MA+LC+ G AVNGVA +HS++ Sbjct: 404 IYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEI 463 Query: 429 VVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPALAALLDKSLQKEWANDLDQLINLE 488 + K +F ++++L P+KF N TNGITPRRW+ CNP LA ++ + + +E+ +DLDQL L Sbjct: 464 LKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLL 523 Query: 489 KFADDAKFRQQYREIKQANKVRLAEFVKVRTGIEINPQAIFDIQIKRLHEYKRQHLNLLH 548 + DD F + ++KQ NK++ A +++ + INP ++FD+Q+KR+HEYKRQ LN LH Sbjct: 524 SYVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLH 583 Query: 549 ILALYKEIRENPQADRVPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDPLVGDKLKV 608 ++ LY I++ P VPR + G KAAPGY++AK II I + DV+N+DP+VGD+L+V Sbjct: 584 VITLYNRIKKEPNKFVVPRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRV 643 Query: 609 VFLPDYCVSAAEKLIPAADISEQISTAGKEASGTGNMKLALNGALTVGTLDGANVEIAEK 668 +FL +Y VS AEK+IPAAD+SEQISTAG EASGTGNMK LNGALT+GT+DGANVE+AE+ Sbjct: 644 IFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEE 703 Query: 669 VGEENIFIFGHTVEQVKAILAKGYDPVKWRKKDKVLDAVLKELESGKYSDGDKHAFDQML 728 GEEN FIFG VE V + +GY+ ++ + L ++++L SG +S F ++ Sbjct: 704 AGEENFFIFGMRVEDVDRLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIV 763 Query: 729 HSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRDQEAWTRAAILNTARCGMFSSDRSIRDY 788 + + D + V AD+ YV+ Q++V LY++ WTR I N A G FSSDR+I Y Sbjct: 764 NMLMHH--DRFKVFADYEEYVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQY 821 Query: 789 QARIW 793 IW Sbjct: 822 AREIW 826 >2ZB2-A nrPDB Length = 849 Score = 657 bits (1694), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/788 (44%), Positives = 499/788 (63%), Gaps = 28/788 (3%) Query: 31 TPRQWWLAVSEALAEMLRAQPFAKPVANQRH--------VNYISMEFLIGRLTGNNLLNL 82 T R ++ A LA +R + + Q+H V Y+S+EF +GR N ++NL Sbjct: 50 TTRDYYFA----LAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINL 105 Query: 83 GWYQDVQDSLKAYDINLTDLLEEEIDPALGNGGLGRLAACFLDSMATVGQSATGYGLNYQ 142 G +++ +++ +L E E D LGNGGLGRLAACFLDSMAT+G +A GYG+ Y+ Sbjct: 106 GLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYE 165 Query: 143 YGLFRQSFVDGKQVEAPDDWHRSNYPWFRHNEALDVQVGIGGKV--TKDG-RWEPEFTIT 199 YG+F Q DG QVE DDW R PW + + V GKV T G +W + Sbjct: 166 YGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVL 225 Query: 200 GQAWDLPVVGYRNGVAQPLRLWQATHAHPFDLTKFNDGDFLRAEQQGINAEKLTKVLYPN 259 +D PV GY N +RLW A + F+L FN GD+++A AE +++VLYPN Sbjct: 226 ALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPN 285 Query: 260 DNHTAGKKLRLMQQYFQCACSVADILRRHHL--------AGRKLHELADYEVIQLNDTHP 311 DN GK+LRL Q+YF A ++ DI+RR AG D IQLNDTHP Sbjct: 286 DNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHP 345 Query: 312 TIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQI 371 +AIPEL+R+ +D ++ W AW +T KTFAYTNHT++PEALERW V LV+ LLPRH++I Sbjct: 346 ALAIPELMRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEI 405 Query: 372 INEINTRFKTLVEKTWPGDEKVWAKLAVVHD---KQVHMANLCVVGGFAVNGVAALHSDL 428 I EIN + + +P D +++++ + K+++MA+LC+VG AVNGVA +HSD+ Sbjct: 406 IYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDI 465 Query: 429 VVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPALAALLDKSLQKEWANDLDQLINLE 488 V +F ++ +L P+KF N TNGITPRRW+ CNP LA L+ + + +++ DL QL L Sbjct: 466 VKTKVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLH 525 Query: 489 KFADDAKFRQQYREIKQANKVRLAEFVKVRTGIEINPQAIFDIQIKRLHEYKRQHLNLLH 548 F D F ++ ++KQ NK++ ++F++ ++INP ++FD+Q+KR+HEYKRQ LN LH Sbjct: 526 SFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLH 585 Query: 549 ILALYKEIRENPQADRVPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDPLVGDKLKV 608 ++ +Y I+++P+ VPR + G KAAPGY++AK II I VADV+NNDP+VG KLKV Sbjct: 586 VITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKV 645 Query: 609 VFLPDYCVSAAEKLIPAADISEQISTAGKEASGTGNMKLALNGALTVGTLDGANVEIAEK 668 +FL +Y VS AEK+IPA D+SEQISTAG EASGTGNMK LNGALT+GT+DGANVE+AE+ Sbjct: 646 IFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEE 705 Query: 669 VGEENIFIFGHTVEQVKAILAKGYDPVKWRKKDKVLDAVLKELESGKYSDGDKHAFDQML 728 GEEN+FIFG ++ V A+ KGY+ ++ + L V+ ++++G +S F ++ Sbjct: 706 AGEENLFIFGMRIDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDII 765 Query: 729 HSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRDQEAWTRAAILNTARCGMFSSDRSIRDY 788 + + D + V AD+ AYV+ Q +V LY + +AW + N A G FSSDR+I++Y Sbjct: 766 NMLFYH--DRFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEY 823 Query: 789 QARIWQAK 796 IW + Sbjct: 824 AQNIWNVE 831 >5IKP-A nrPDB Length = 846 Score = 649 bits (1675), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/785 (44%), Positives = 496/785 (63%), Gaps = 28/785 (3%) Query: 31 TPRQWWLAVSEALAEMLRAQPFAKPVANQRH--------VNYISMEFLIGRLTGNNLLNL 82 TPR ++ A LA +R + + Q+H + Y+S+EF +GR N ++NL Sbjct: 51 TPRDYFFA----LAHTVRDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTMVNL 106 Query: 83 GWYQDVQDSLKAYDINLTDLLEEEIDPALGNGGLGRLAACFLDSMATVGQSATGYGLNYQ 142 G +++ ++L +L E E D LGNGGLGRLAACFLDSMAT+G +A GYG+ Y+ Sbjct: 107 GLQNACDEAIYQLGLDLEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYE 166 Query: 143 YGLFRQSFVDGKQVEAPDDWHRSNYPWFRHNEALDVQVGIGGKV--TKDG-RWEPEFTIT 199 +G+F Q V+G QVE DDW R PW + + V G+V T DG +W + Sbjct: 167 FGIFNQKIVNGWQVEEADDWLRYGNPWEKARPEYMLPVHFYGRVEHTPDGVKWLDTQVVL 226 Query: 200 GQAWDLPVVGYRNGVAQPLRLWQATHAHPFDLTKFNDGDFLRAEQQGINAEKLTKVLYPN 259 +D PV GY+N +RLW A + F L FN GD++ A AE +++VLYPN Sbjct: 227 AMPYDTPVPGYKNNTVNTMRLWSAKAPNDFKLQDFNVGDYIEAVLDRNLAENISRVLYPN 286 Query: 260 DNHTAGKKLRLMQQYFQCACSVADILRRHHLAG-------RKLHE-LADYEVIQLNDTHP 311 DN GK+LRL Q+YF A ++ DI+RR + R E D IQLNDTHP Sbjct: 287 DNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTCFETFPDKVAIQLNDTHP 346 Query: 312 TIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQI 371 ++IPEL+R+L+D ++ WD AW IT KT AYTNHT++PEALERW V + + LLPRH++I Sbjct: 347 ALSIPELMRILVDVEKVDWDKAWEITKKTCAYTNHTVLPEALERWPVSMFEKLLPRHLEI 406 Query: 372 INEINTRFKTLVEKTWPGDEKVWAKLAVVHD---KQVHMANLCVVGGFAVNGVAALHSDL 428 I IN R V +PGD +++V+ + K+++MA+LCV+G AVNGVA +HS++ Sbjct: 407 IYAINQRHLDHVAALFPGDVDRLRRMSVIEEGDCKRINMAHLCVIGSHAVNGVARIHSEI 466 Query: 429 VVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPALAALLDKSLQKEWANDLDQLINLE 488 V + +F ++++L P KF N TNGITPRRW+ CNP LA + + + +E+ DL QL L Sbjct: 467 VKQSVFKDFYELEPEKFQNKTNGITPRRWLLLCNPGLADTIVEKIGEEFLTDLSQLKKLL 526 Query: 489 KFADDAKFRQQYREIKQANKVRLAEFVKVRTGIEINPQAIFDIQIKRLHEYKRQHLNLLH 548 D F + ++KQ NK++ + F++ ++INP ++FD+ +KR+HEYKRQ LN LH Sbjct: 527 PLVSDEVFIRDVAKVKQENKLKFSAFLEKEYKVKINPSSMFDVHVKRIHEYKRQLLNCLH 586 Query: 549 ILALYKEIRENPQADRVPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDPLVGDKLKV 608 ++ LY I+ +P VPR + G KAAPGY++AK II + + DV+N+DP+VGD+LKV Sbjct: 587 VVTLYNRIKRDPAKAFVPRTVMIGGKAAPGYHMAKLIIKLVTSIGDVVNHDPVVGDRLKV 646 Query: 609 VFLPDYCVSAAEKLIPAADISEQISTAGKEASGTGNMKLALNGALTVGTLDGANVEIAEK 668 +FL +Y VS AEK+IPAAD+S+QISTAG EASGTGNMK LNGALT+GT+DGANVE+AE+ Sbjct: 647 IFLENYRVSLAEKVIPAADLSQQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEE 706 Query: 669 VGEENIFIFGHTVEQVKAILAKGYDPVKWRKKDKVLDAVLKELESGKYSDGDKHAFDQML 728 G EN+FIFG VE V+A+ KGY+ ++ L + ++ SG +S + F ++ Sbjct: 707 AGAENLFIFGLRVEDVEALDRKGYNAREYYDHLPELKQAVDQISSGFFSPKEPDCFKDIV 766 Query: 729 HSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRDQEAWTRAAILNTARCGMFSSDRSIRDY 788 + + D + V AD+ AY++ Q QVD LYR+ + WT+ I N A G FSSDR+I +Y Sbjct: 767 NMLMHH--DRFKVFADYEAYMQCQAQVDQLYRNPKEWTKKVIRNIACSGKFSSDRTITEY 824 Query: 789 QARIW 793 IW Sbjct: 825 AREIW 829 >4BQE-A nrPDB Length = 874 Score = 635 bits (1639), Expect = 0.0, Method: Compositional matrix adjust. Identities = 336/753 (44%), Positives = 471/753 (62%), Gaps = 21/753 (2%) Query: 60 RHVNYISMEFLIGRLTGNNLLNLGWYQDVQDSLKAYDINLTDLLEEEIDPALGNGGLGRL 119 + Y+SME+L GR N + NL D+L+ L ++ E+E D ALGNGGLGRL Sbjct: 116 KQTYYLSMEYLQGRALTNAIGNLNLQGPYADALRTLGYELEEIAEQEKDAALGNGGLGRL 175 Query: 120 AACFLDSMATVGQSATGYGLNYQYGLFRQSFVDGKQVEAPDDWHRSNYPW--FRHNEALD 177 A+CFLDSMAT+ A GYGL Y++GLF+Q Q E P+DW PW RH+ Sbjct: 176 ASCFLDSMATLNLPAWGYGLRYRHGLFKQIITKKGQEEIPEDWLEKFSPWEIVRHDVVFP 235 Query: 178 VQVGIGGKVTKDG--RWEPEFTITGQAWDLPVVGYRNGVAQPLRLWQA-THAHPFDLTKF 234 V+ +V DG +W + A+D+P+ GY LRLW+A A DL +F Sbjct: 236 VRFFGKVQVNPDGSRKWVDGDVVQALAYDVPIPGYGTKNTISLRLWEAKARAEDLDLFQF 295 Query: 235 NDGDFLRAEQQGINAEKLTKVLYPNDNHTAGKKLRLMQQYFQCACSVADILRRHHL---- 290 N+G++ A Q A+++ VLYP D GK LRL QQ+F C+ S+ DI+ R H Sbjct: 296 NEGEYELAAQLHSRAQQICTVLYPGDATENGKLLRLKQQFFLCSASLQDIISRFHERSTT 355 Query: 291 -AGRKLHELADYEVIQLNDTHPTIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLM 349 RK E +Q+NDTHPT+AIPEL+R+L+D++ + WD+AW +TSKT AYTNHT++ Sbjct: 356 EGSRKWSEFPSKVAVQMNDTHPTLAIPELMRLLMDDNGLGWDEAWDVTSKTVAYTNHTVL 415 Query: 350 PEALERWDVKLVKGLLPRHMQIINEINTRFKTLVEKTWPGDEKVWAKLAVVHDKQ----V 405 PEALE+W L+ LLPRHM+II EI+ RF + T E + L+++ + V Sbjct: 416 PEALEKWSQSLMWKLLPRHMEIIEEIDKRFVQTIRDTRVDLEDKISSLSILDNNPQKPVV 475 Query: 406 HMANLCVVGGFAVNGVAALHSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPAL 465 MANLCVV VNGVA LHSD++ +LF +Y +WPNKF N TNGITPRRW++ C+P L Sbjct: 476 RMANLCVVSSHTVNGVAQLHSDILKAELFADYVSIWPNKFQNKTNGITPRRWLRFCSPEL 535 Query: 466 AALLDKSLQKE-WANDLDQLINLEKFADDAKFRQQYREIKQANKVRLAEFVKVRTGIEIN 524 + ++ K L+ + W DLD L L +FAD+ + + ++ K ANK RLA++++ TG+ I+ Sbjct: 536 SDIITKWLKTDKWITDLDLLTGLRQFADNEELQSEWASAKTANKKRLAQYIERVTGVSID 595 Query: 525 PQAIFDIQIKRLHEYKRQHLNLLHILALYKEIRENPQADR---VPRVFLFGAKAAPGYYL 581 P ++FDIQ+KR+HEYKRQ +N+L ++ +K+++E +R VPR + G KA Y Sbjct: 596 PTSLFDIQVKRIHEYKRQLMNILGVVYRFKKLKEMKPEERKKTVPRTVMIGGKAFATYTN 655 Query: 582 AKNIIFAINKVADVINNDPLVGDKLKVVFLPDYCVSAAEKLIPAADISEQISTAGKEASG 641 AK I+ +N V DV+N+DP V + LKVVF+P+Y V+ AE LIP +++S+ ISTAG EASG Sbjct: 656 AKRIVKLVNDVGDVVNSDPEVNEYLKVVFVPNYNVTVAEMLIPGSELSQHISTAGMEASG 715 Query: 642 TGNMKLALNGALTVGTLDGANVEIAEKVGEENIFIFGHTVEQVKAILAKGYDPVKWRKKD 701 T NMK ALNG L +GTLDGANVEI E+VGEEN F+FG T +QV + + D + K D Sbjct: 716 TSNMKFALNGCLIIGTLDGANVEIREEVGEENFFLFGATADQVPRLRKEREDGL--FKPD 773 Query: 702 KVLDAVLKELESGKYSDGDKHA-FDQMLHSIGKQGGDPYLVMADFAAYVEAQKQVDVLYR 760 + + ++SG + D D + + G GD +LV DF +Y++AQ +VD Y+ Sbjct: 774 PRFEEAKQFVKSGVFGSYDYGPLLDSLEGNTGFGRGDYFLVGYDFPSYMDAQAKVDEAYK 833 Query: 761 DQEAWTRAAILNTARCGMFSSDRSIRDYQARIW 793 D++ W + +IL+TA G FSSDR+I Y IW Sbjct: 834 DRKGWLKMSILSTAGSGKFSSDRTIAQYAKEIW 866 >2C4M-A nrPDB Length = 796 Score = 633 bits (1633), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/776 (45%), Positives = 476/776 (61%), Gaps = 29/776 (3%) Query: 31 TPRQWWLAVSEALAEML-----RAQPFAKPVANQRHVNYISMEFLIGRLTGNNLLNLGWY 85 T R++W +S A+ E + R + A A Q+H Y S EFL+GR NNL NLG Sbjct: 29 TDRKFWTGLSRAVQERIADDWERTRE-AYGAARQQH--YFSAEFLMGRALLNNLTNLGLV 85 Query: 86 QDVQDSLKAYDINLTDLLEEEIDPALGNGGLGRLAACFLDSMATVGQSATGYGLNYQYGL 145 + + + LTD+LE E D ALGNGGLGRLAACFLDS T TGYGL Y++GL Sbjct: 86 DEAAAATRELGHELTDILEIENDAALGNGGLGRLAACFLDSAVTQDYPVTGYGLLYRFGL 145 Query: 146 FRQSFVDGKQVEAPDDWHRSNYPWFRHNEALDVQVGIGGKVTKDGRWEPEFTITGQAWDL 205 FRQSF +G QVE PD W YP+ + + V T+ +D+ Sbjct: 146 FRQSFNEGFQVEKPDPWREEEYPFTIRRASDQLVVCFDDMKTR-----------AIPYDM 194 Query: 206 PVVGYRNGVAQPLRLWQATHAHPFDLTKFNDGDFLRAEQQGINAEKLTKVLYPNDNHTAG 265 P+ GY LRLW+A FD FN F A + + +VLYPND G Sbjct: 195 PITGYGTHNVGTLRLWKAEPWEEFDYDAFNAQRFTDAIIERERVSDICRVLYPNDTTYEG 254 Query: 266 KKLRLMQQYFQCACSVADILRRHHLAGRKLHELADYEVIQLNDTHPTIAIPELLRVLIDE 325 KKLR+ QQYF + S+ +++ H + L A++ +QLNDTHP +AIPEL+R+L+DE Sbjct: 255 KKLRVRQQYFFTSASLQAMIQDHLAHHKDLSNFAEFHSVQLNDTHPVLAIPELMRLLMDE 314 Query: 326 HQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQIINEINTRFKTLVEK 385 H M W+++WAI SKTFAYTNHT++ EALE+WD ++ + L R +II EI+ RF+ +E+ Sbjct: 315 HDMGWEESWAIVSKTFAYTNHTVLTEALEQWDEQIFQQLFWRVWEIIAEIDRRFR--LER 372 Query: 386 TWPG-DEKVWAKLAVVHDKQVHMANLCVVGGFAVNGVAALHSDLVVKDLFPEYHQLWPNK 444 G DE+ ++A + VHMA + +++NGVAALH++++ + +++ LWP K Sbjct: 373 AADGLDEETINRMAPIQHGTVHMAWIACYAAYSINGVAALHTEIIKAETLADWYALWPEK 432 Query: 445 FHNVTNGITPRRWIKQCNPALAALLDK-SLQKEWANDLDQLINLEKFADDAKFRQQYREI 503 F+N TNG+TPRRW++ NP L+ LL + S +W DLD+L L +ADD ++ R I Sbjct: 433 FNNKTNGVTPRRWLRMINPGLSDLLTRLSGSDDWVTDLDELKKLRSYADDKSVLEELRAI 492 Query: 504 KQANKVRLAEFVKVRTGIEINPQAIFDIQIKRLHEYKRQHLNLLHILALYKEIRENPQAD 563 K ANK AE++ R GIEI+P++IFD+QIKRLHEYKRQ +N L++L LY I+E+ D Sbjct: 493 KAANKQDFAEWILERQGIEIDPESIFDVQIKRLHEYKRQLMNALYVLDLYFRIKEDGLTD 552 Query: 564 RVPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDPLVGDKLKVVFLPDYCVSAAEKLI 623 R +FGAKAAPGY AK II IN +AD++NNDP V LKVVF+ +Y VS AE ++ Sbjct: 553 IPARTVIFGAKAAPGYVRAKAIIKLINSIADLVNNDPEVSPLLKVVFVENYNVSPAEHIL 612 Query: 624 PAADISEQISTAGKEASGTGNMKLALNGALTVGTLDGANVEIAEKVGEENIFIFGHTVEQ 683 PA+D+SEQISTAGKEASGT NMK +NGALT+GT+DGANVEI + VGEEN +IFG VE+ Sbjct: 613 PASDVSEQISTAGKEASGTSNMKFMMNGALTLGTMDGANVEIVDSVGEENAYIFGARVEE 672 Query: 684 VKAILAKGYDPVKWRKKDKVLDAVLKELESGKYSDGDKHAFDQMLHSI----GKQGGDPY 739 + A L + Y P + + L L L++G +D + F + HS+ GK D Y Sbjct: 673 LPA-LRESYKPYELYETVPGLKRALDALDNGTLNDNNSGLFYDLKHSLIHGYGKDASDTY 731 Query: 740 LVMADFAAYVEAQKQVDVLY-RDQEAWTRAAILNTARCGMFSSDRSIRDYQARIWQ 794 V+ DFA Y E + ++ Y D W R A +N G FSSDR+IRDY IW+ Sbjct: 732 YVLGDFADYRETRDRMAADYASDPLGWARMAWINICESGRFSSDRTIRDYATEIWK 787 >1YGP-A nrPDB Length = 879 Score = 603 bits (1555), Expect = e-173, Method: Compositional matrix adjust. Identities = 346/785 (44%), Positives = 482/785 (61%), Gaps = 53/785 (6%) Query: 60 RHVNYISMEFLIGRLTGNNLLNLGWYQDVQD--------------SLKAYDINLTDLLEE 105 + V Y+S+EFL+GR N L+N+ +D +D +L L D+L++ Sbjct: 97 KRVYYLSLEFLMGRALDNALINMK-IEDPEDPAASKGKPREMIKGALDELGFKLEDVLDQ 155 Query: 106 EIDPALGNGGLGRLAACFLDSMATVGQSATGYGLNYQYGLFRQSFVDGKQVEAPDDWHRS 165 E D LGNGGLGRLAACF+DSMAT G A GYGL Y+YG+F Q +DG QVE PD W S Sbjct: 156 EPDAGLGNGGLGRLAACFVDSMATEGIPAWGYGLRYEYGIFAQKIIDGYQVETPDYWLNS 215 Query: 166 NYPWFRHNEALDVQVGI--------GGKVT-KDGRWEPEFTITGQAWDLPVVGYRNGVAQ 216 PW + + V GGK T +W + A+D PV G++ Sbjct: 216 GNPWEIERNEVQIPVTFYGYVDRPEGGKTTLSASQWIGGERVLAVAYDFPVPGFKTSNVN 275 Query: 217 PLRLWQATHAHPFDLTKFNDGDFLRAEQQGINAEKLTKVLYPNDNHTAGKKLRLMQQYFQ 276 LRLWQA FDL KFN+GD+ + Q AE +T VLYPNDN GK+LRL QQYF Sbjct: 276 NLRLWQARPTTEFDLNKFNNGDYKNSVAQQQRAESITAVLYPNDNFAQGKELRLKQQYFW 335 Query: 277 CACSVADILRRHHLAGRKLHELADYEVIQLNDTHPTIAIPELLRVLIDEHQMSWDDAWAI 336 CA S+ DILRR + R E D IQLNDTHPT+AI EL RVL+D ++ W +AW I Sbjct: 336 CAASLHDILRRFKKSKRPWTEFPDQVAIQLNDTHPTLAIVELQRVLVDLEKLDWHEAWDI 395 Query: 337 TSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQIINEINTRFKTLVEKTWPGDEKVWAK 396 +KTFAYTNHT+M EALE+W +L LLPRH++II +IN F V K +P D + ++ Sbjct: 396 VTKTFAYTNHTVMQEALEKWPRRLFGHLLPRHLEIIYDINWFFLEDVAKKFPKDVDLLSR 455 Query: 397 LAVVH----DKQVHMANLCVVGGFAVNGVAALHSDLVVKDLFPEYHQLW-PNKFHNVTNG 451 ++++ ++Q+ MA L +VG VNGV LHS+L+ +F ++ + + P+KF NVTNG Sbjct: 456 ISIIEENSPERQIRMAFLAIVGSHKVNGVVELHSELIKTTIFKDFIKFYGPSKFVNVTNG 515 Query: 452 ITPRRWIKQCNPALAALLDKSLQ---KEWANDLDQLINLEKFADDAKFRQQYREIKQANK 508 ITPRRW+KQ NP+LA L+ ++L +E+ D+ +L LEK+ +D +F +++ ++K NK Sbjct: 516 ITPRRWLKQANPSLAKLISETLNDPTEEYLLDMAKLTQLEKYVEDKEFLKKWNQVKLNNK 575 Query: 509 VRLAEFVKVRT-GIEINPQ-----AIFDIQIKRLHEYKRQHLNLLHILALYKEIRE---- 558 +RL + +K G++I + +FD+Q+KR+HEYKRQ LN+ I+ Y ++ Sbjct: 576 IRLVDLIKKENDGVDIINREYLDDTLFDMQVKRIHEYKRQQLNVFGIIYRYLAMKNMLKN 635 Query: 559 ----NPQADRVPR-VFLFGAKAAPGYYLAKNIIFAINKVADVINNDPLVGDKLKVVFLPD 613 A + PR V +FG K+APGYY+AK II IN VAD++NND + LKVVF+ D Sbjct: 636 GASIEEVARKYPRKVSIFGGKSAPGYYMAKLIIKLINCVADIVNNDESIEHLLKVVFVAD 695 Query: 614 YCVSAAEKLIPAADISEQISTAGKEASGTGNMKLALNGALTVGTLDGANVEIAEKVGEEN 673 Y VS AE +IPA+D+SE ISTAG EASGT NMK +NG L +GT+DGANVEI ++GE+N Sbjct: 696 YNVSKAEIIIPASDLSEHISTAGTEASGTSNMKFVMNGGLIIGTVDGANVEITREIGEDN 755 Query: 674 IFIFGHTVEQVKAI-LAKGYDPVKWRKKDKVLDAVLKELESGKYSDGDKHAFDQMLHSIG 732 +F+FG+ E V+ + Y P + LD+VL +ESG++S + + F ++ SI Sbjct: 756 VFLFGNLSENVEELRYNHQYHP---QDLPSSLDSVLSYIESGQFSPENPNEFKPLVDSI- 811 Query: 733 KQGGDPYLVMADFAAYVEAQKQVDVLYRDQEA-WTRAAILNTARCGMFSSDRSIRDYQAR 791 K GD YLV DF +Y+ + VD + +Q + W + ++L+ A G FSSDR I +Y Sbjct: 812 KYHGDYYLVSDDFESYLATHELVDQEFHNQRSEWLKKSVLSLANVGFFSSDRCIEEYSDT 871 Query: 792 IWQAK 796 IW + Sbjct: 872 IWNVE 876 >4L22-A nrPDB Length = 758 Score = 496 bits (1278), Expect = e-140, Method: Compositional matrix adjust. Identities = 286/746 (38%), Positives = 432/746 (57%), Gaps = 42/746 (5%) Query: 57 ANQRHVNYISMEFLIGRLTGNNLLNLGWYQDVQDSLKAYDINLTDLLEEEIDPALGNGGL 116 ++R V YIS EFLIG+L NNL+NLG Y+ V+D L A +++ + + E++P+LGNGGL Sbjct: 47 TSKRKVYYISAEFLIGKLLSNNLINLGLYKTVKDELAAAGKSISQVEDVELEPSLGNGGL 106 Query: 117 GRLAACFLDSMATVGQSATGYGLNYQYGLFRQSFVDGKQVEAPDDWHRSNYPWFRHNEAL 176 GRLA+CF+DSMAT+G + G GLNY GLF+Q F D +Q P+ W + W Sbjct: 107 GRLASCFIDSMATLGINGEGVGLNYHCGLFKQVFRDNQQEAEPNYWIEDD-SWL------ 159 Query: 177 DVQVGIGGKVTKDGRWEPEFTITGQAWDLPVVGYRNGVAQPLRLWQATHAHPFDLTKFND 236 + ++ D + +FT+ + + ++GY L L+ D D Sbjct: 160 -----VPTAISYDVPFR-DFTLKSKLDRIDILGYHKDSKNYLNLFDID---GLDYGLIKD 210 Query: 237 G-DFLRAEQQGINAEKLTKVLYPNDNHTAGKKLRLMQQYFQCACSVADILRRHHLAGRKL 295 G F + E + + LT LYP+D+ G+ LR+ QQYF + + ++ G L Sbjct: 211 GITFDKTEIK----KNLTLFLYPDDSDKNGELLRIYQQYFMVSNAAQLLIDEALERGSNL 266 Query: 296 HELADYEVIQLNDTHPTIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLMPEALER 355 H+LADY +Q+NDTHP++ IPEL+R+L ++H + + +A I YTNHT++ EALE+ Sbjct: 267 HDLADYAYVQINDTHPSMVIPELIRLLNEKHGLDFYEAVDIVKNMIGYTNHTILAEALEK 326 Query: 356 WDVKLVKGLLPRHMQIINEINTRFKTLVEKTWPGDEKVWAKLAVVHDKQVHMANLCVVGG 415 W ++ + ++P + II ++ +V + D A + D +VHMA++ + Sbjct: 327 WPLEYLNEVVPHLVTIIEHLDR----IVRSQYKDD----AVQIIDRDDRVHMAHMDIHFS 378 Query: 416 FAVNGVAALHSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPALAALLDKSLQK 475 +VNGVAALH+D++ ++ ++P KF+N TNGIT RRW++ N LAA + + + + Sbjct: 379 TSVNGVAALHTDILKNSELKPFYDIYPEKFNNKTNGITFRRWLEFANQDLAAYIKELIGE 438 Query: 476 EWANDLDQLINLEKFADDAKFRQQYREIKQANKVRLAEFVKVRTGIEINPQAIFDIQIKR 535 + D +L L FADD +Q +IK NK+ L ++K GI ++ +I D QIKR Sbjct: 439 GYLEDATELEKLLAFADDKTVHEQLAKIKFNNKLALKRYLKENKGINLDENSIIDTQIKR 498 Query: 536 LHEYKRQHLNLLHILALYKEIRENPQADRVPRVFLFGAKAAPGYYLAKNIIFAINKVADV 595 HEYKRQ +N L+++ Y EI++ R V +FG KAAP Y +A++II I ++++ Sbjct: 499 FHEYKRQQMNALYVIYKYLEIKKGNLPKRKITV-IFGGKAAPAYTIAQDIIHLILCLSEL 557 Query: 596 INNDPLVGDKLKVVFLPDYCVSAAEKLIPAADISEQISTAGKEASGTGNMKLALNGALTV 655 INNDP V L V + +Y V+ AEKLIPA DISEQIS A KEASGTGNMK LNGALT+ Sbjct: 558 INNDPDVSPYLNVFLVENYNVTVAEKLIPATDISEQISLASKEASGTGNMKFMLNGALTL 617 Query: 656 GTLDGANVEIAEKVGEENIFIFGHTVEQVKAILAKGYDPVKWRKKDKVL-DAVLKE---- 710 GT+DGANVEIAE VG +NI+IFG + + + YD + KD +AV+KE Sbjct: 618 GTMDGANVEIAELVGSDNIYIFGKDSDTIIDL----YDKGTYVSKDYYTNNAVIKEAVDF 673 Query: 711 -LESGKYSDGDKHAFDQMLHSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRDQEAWTRAA 769 + + G K +++ H + + D ++ + D Y+ ++++ Y DQ W + Sbjct: 674 IVSKDVLALGKKERLERLYHELINK--DWFMTLIDLKEYIAKKEEMLADYEDQNVWNKKV 731 Query: 770 ILNTARCGMFSSDRSIRDYQARIWQA 795 I N A+ G FSSDR+I+ Y IW + Sbjct: 732 IQNIAKAGFFSSDRTIQQYDKDIWHS 757 >5LR8-A nrPDB Length = 938 Score = 372 bits (954), Expect = e-103, Method: Compositional matrix adjust. Identities = 203/459 (44%), Positives = 293/459 (63%), Gaps = 23/459 (5%) Query: 349 MPEALERWDVKLVKGLLPRHMQIINEINTRFKTLVEKTWPGDE-KVWAKLAVVHDKQVHM 407 + EA E+ + + V+ +L + E ++ EK P E +AK + V M Sbjct: 469 IAEADEKTESQEVENILSETTEKKAESDSEEAPDAEKEDPEYELDPFAKYDPQFPRVVRM 528 Query: 408 ANLCVVGGFAVNGVAALHSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPALAA 467 ANLCVVGG +VNGVA +HS++V +D+F ++++WP KF N TNG+TPRRWI+ CNP L+ Sbjct: 529 ANLCVVGGHSVNGVAEIHSEIVKQDVFNSFYEMWPTKFQNKTNGVTPRRWIRFCNPELST 588 Query: 468 LLDKSL-QKEWANDLDQLINLEKFADDAKFRQQYREIKQANKVRLAEFVKVRTGIEINPQ 526 ++ K + +W + D+L L+KFADD + ++R K+ NK+++ ++ +TG ++P Sbjct: 589 IISKWIGSDDWILNTDKLAGLKKFADDEDLQSEWRTAKRNNKMKVVSLIRDKTGYIVSPD 648 Query: 527 AIFDIQIKRLHEYKRQHLNLLHILALYKEIRENPQADR----VPRVFLFGAKAAPGYYLA 582 A+FD+Q+KR+HEYKRQ LN+L I+ YK+++E DR VPRV +FG KA Y A Sbjct: 649 AMFDVQVKRIHEYKRQLLNILGIVYRYKKMKEMSAKDRRKSFVPRVCIFGGKAFATYVQA 708 Query: 583 KNIIFAINKVADVINNDPLVGDKLKVVFLPDYCVSAAEKLIPAADISEQISTAGKEASGT 642 K I+ I VA +N DP +GD LKVVF+PDY VS AE LIPA+++S+ ISTAG EASGT Sbjct: 709 KRIVKFITDVAATVNYDPDIGDLLKVVFVPDYNVSVAETLIPASELSQHISTAGMEASGT 768 Query: 643 GNMKLALNGALTVGTLDGANVEIAEKVGEENIFIFGHTVEQVKAI---LAKG-YDPVKWR 698 NMK A+NG L +GTLDGANVEI E+VGEEN F+FG ++ + A+G + P Sbjct: 769 SNMKFAMNGCLLIGTLDGANVEIREEVGEENFFLFGAHAPEIAGLRQERAEGKFVP---- 824 Query: 699 KKDKVLDAVLKELESGKYSDGDKHAFDQMLHSI-GKQG---GDPYLVMADFAAYVEAQKQ 754 D + V + + SG + + +D+++ S+ G +G D +LV DF +Y+E Q++ Sbjct: 825 --DLRFEEVKEYVRSGVFGTSN---YDELMGSLEGNEGYGRADYFLVGKDFPSYIECQEK 879 Query: 755 VDVLYRDQEAWTRAAILNTARCGMFSSDRSIRDYQARIW 793 VD YRDQ+ WTR +ILNTA FSSDR+I +Y IW Sbjct: 880 VDEAYRDQKLWTRMSILNTAGSPKFSSDRTIHEYAKDIW 918 Score = 277 bits (708), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 147/327 (44%), Positives = 198/327 (60%), Gaps = 8/327 (2%) Query: 58 NQRHVNYISMEFLIGRLTGNNLLNLGWYQDVQDSLKAYDINLTDLLEEEIDPALGNGGLG 117 N + Y+SMEFL GR N + NL ++LK NL D+ +E DPALGNGGLG Sbjct: 83 NAKQAYYLSMEFLQGRALTNAIGNLELTGQYAEALKQLGHNLEDVASQEPDPALGNGGLG 142 Query: 118 RLAACFLDSMATVGQSATGYGLNYQYGLFRQSFVDGKQVEAPDDWHRSNYPWFRHNEALD 177 RLA+CFLDS+AT+ A GYGL Y+YGLF+Q Q E ++W PW + Sbjct: 143 RLASCFLDSLATLNYPAWGYGLRYRYGLFKQIITKDGQEEVAENWLEMGNPWEIVRNDVS 202 Query: 178 VQVGIGGKVTK--DGR--WEPEFTITGQAWDLPVVGYRNGVAQPLRLWQAT-HAHPFDLT 232 V GKV + DGR W I A D+P+ GY+ LRLW T + FDL Sbjct: 203 YPVKFYGKVVEGTDGRKHWIGGENIKAVAHDVPIPGYKTKTTNNLRLWSTTVPSQNFDLG 262 Query: 233 KFNDGDFLRAEQQGINAEKLTKVLYPNDNHTAGKKLRLMQQYFQCACSVADILRR-HHLA 291 FN GD +A + +NAEK+ VLYP D + GK LRL QQY C+ S+ DI+ R A Sbjct: 263 AFNAGDHAKANEAHLNAEKICHVLYPGDESSEGKILRLKQQYTLCSASLQDIISRFESRA 322 Query: 292 GRKLH--ELADYEVIQLNDTHPTIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLM 349 G L+ + +Q+NDTHPT+ IPEL+R+L+D +SW++AW+IT +T AYTNHT++ Sbjct: 323 GDSLNWEDFPSKVAVQMNDTHPTLCIPELMRILMDIKGLSWNEAWSITERTVAYTNHTVL 382 Query: 350 PEALERWDVKLVKGLLPRHMQIINEIN 376 PEALE+W + +++ LLPRH++II I+ Sbjct: 383 PEALEKWSLDIMQKLLPRHVEIIETID 409 >4BHW-A nrPDB Length = 578 Score = 35.4 bits (80), Expect = 0.11, Method: Compositional matrix adjust. Identities = 33/131 (25%), Positives = 56/131 (42%), Gaps = 20/131 (15%) Query: 79 LLNLGW-YQDVQDSLKAYDINLTDLLEEEIDPALGNGG--LGR-------LAACFLDSMA 128 + N W Y + Y L+++ E+EIDP + + G GR C+ + Sbjct: 92 MFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLC 151 Query: 129 TVGQSATGYGLNYQYGLFRQSF--VDGKQVEAPDDWHRS----NYPWF--RHNEALDVQV 180 T+ + AT Y +Y + F + G+ V DD + N F R N+ LD ++ Sbjct: 152 TIPRDATYYSYQNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPEL 211 Query: 181 GIGGKVTKDGR 191 + + T+ GR Sbjct: 212 FV--ECTECGR 220 >5XZC-A nrPDB Length = 619 Score = 35.4 bits (80), Expect = 0.11, Method: Compositional matrix adjust. Identities = 33/131 (25%), Positives = 56/131 (42%), Gaps = 20/131 (15%) Query: 79 LLNLGW-YQDVQDSLKAYDINLTDLLEEEIDPALGNGG--LGR-------LAACFLDSMA 128 + N W Y + Y L+++ E+EIDP + + G GR C+ + Sbjct: 79 MFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLC 138 Query: 129 TVGQSATGYGLNYQYGLFRQSF--VDGKQVEAPDDWHRS----NYPWF--RHNEALDVQV 180 T+ + AT Y +Y + F + G+ V DD + N F R N+ LD ++ Sbjct: 139 TIPRDATYYSYQNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPEL 198 Query: 181 GIGGKVTKDGR 191 + + T+ GR Sbjct: 199 FV--ECTECGR 207 >6HMF-A nrPDB Length = 475 Score = 33.1 bits (74), Expect = 0.48, Method: Compositional matrix adjust. Identities = 30/120 (25%), Positives = 50/120 (41%), Gaps = 4/120 (3%) Query: 405 VHMANLCVVGGFAVNGVAAL---HSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQC 461 V ++ G V+G+ +SDLV+ D+F +Y L N NV IT Sbjct: 249 VSRVKYLIIAGDVVDGIGIYPGQYSDLVIPDIFDQYEALA-NLLANVPEHITMFIGPGNA 307 Query: 462 NPALAALLDKSLQKEWANDLDQLINLEKFADDAKFRQQYREIKQANKVRLAEFVKVRTGI 521 + A A+ KE+A + +L N ++ A R R+ A+ + + V G+ Sbjct: 308 DAARPAIPQPEFYKEYAKPIYKLKNAIIISNPAVIRLHGRDFLIAHGRGIEDVVSFVPGL 367 >2HTW-A nrPDB Length = 390 Score = 33.1 bits (74), Expect = 0.48, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%) Query: 148 QSFVDGKQVEA--PDDWHRSNYPWFRHNEALDVQVG 181 + G+ VE D+W SN PW R N LD Q+G Sbjct: 199 SCYPSGENVECVCRDNWRGSNRPWIRFNSDLDYQIG 234 >6HMS-A nrPDB Length = 400 Score = 33.1 bits (74), Expect = 0.52, Method: Compositional matrix adjust. Identities = 30/120 (25%), Positives = 50/120 (41%), Gaps = 4/120 (3%) Query: 405 VHMANLCVVGGFAVNGVAAL---HSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQC 461 V ++ G V+G+ +SDLV+ D+F +Y L N NV IT Sbjct: 174 VSRVKYLIIAGDVVDGIGIYPGQYSDLVIPDIFDQYEALA-NLLANVPEHITMFIGPGNA 232 Query: 462 NPALAALLDKSLQKEWANDLDQLINLEKFADDAKFRQQYREIKQANKVRLAEFVKVRTGI 521 + A A+ KE+A + +L N ++ A R R+ A+ + + V G+ Sbjct: 233 DAARPAIPQPEFYKEYAKPIYKLKNAIIISNPAVIRLHGRDFLIAHGRGIEDVVSFVPGL 292 >4B7M-A nrPDB Length = 469 Score = 32.0 bits (71), Expect = 1.1, Method: Compositional matrix adjust. Identities = 11/22 (50%), Positives = 15/22 (68%) Query: 160 DDWHRSNYPWFRHNEALDVQVG 181 D+WH SN PW N+ L+ Q+G Sbjct: 294 DNWHGSNRPWVSFNQNLEYQIG 315 >3TI5-A nrPDB Length = 388 Score = 31.6 bits (70), Expect = 1.3, Method: Compositional matrix adjust. Identities = 11/22 (50%), Positives = 15/22 (68%) Query: 160 DDWHRSNYPWFRHNEALDVQVG 181 D+WH SN PW N+ L+ Q+G Sbjct: 213 DNWHGSNRPWVSFNQNLEYQIG 234 >2HU4-A nrPDB Length = 387 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 11/22 (50%), Positives = 15/22 (68%) Query: 160 DDWHRSNYPWFRHNEALDVQVG 181 D+WH SN PW N+ L+ Q+G Sbjct: 212 DNWHGSNRPWVSFNQNLEYQIG 233 >4V8M-A0 nrPDB Length = 256 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 18/64 (28%), Positives = 34/64 (53%), Gaps = 3/64 (4%) Query: 30 MTPRQWWLAVSEALAEMLRAQPFAKPVANQRHVNYISMEFLIGRLTGNNLLNLGWYQDVQ 89 M+ ++W+ V+ E+ + FAK + N+ I+ +FL GR+ NL +L Q+ Sbjct: 24 MSRKEWYDVVAPKNFEV---RQFAKTICNKTQGTKIAADFLRGRVYEGNLADLNKTQNED 80 Query: 90 DSLK 93 D+ + Sbjct: 81 DAYR 84 >3CYE-A nrPDB Length = 387 Score = 31.6 bits (70), Expect = 1.5, Method: Compositional matrix adjust. Identities = 11/22 (50%), Positives = 15/22 (68%) Query: 160 DDWHRSNYPWFRHNEALDVQVG 181 D+WH SN PW ++ LD Q+G Sbjct: 212 DNWHGSNRPWVSFDQNLDYQIG 233 >3TQQ-A nrPDB Length = 314 Score = 31.2 bits (69), Expect = 2.0, Method: Compositional matrix adjust. Identities = 19/74 (25%), Positives = 34/74 (45%), Gaps = 12/74 (16%) Query: 215 AQPLRLWQATHAHPFDLTKFNDGDFLRAEQQGINAEKLTKVLYPNDNHTAGKKLRLMQQY 274 QP+R+W+AT + T F G + A+++GI+ + +L + GK++ Sbjct: 241 GQPMRIWRATVVD--EKTDFEPGVLVDADKKGISIAAGSGILRLHQLQLPGKRV------ 292 Query: 275 FQCACSVADILRRH 288 CS D + H Sbjct: 293 ----CSAGDFINAH 302 >4AMU-A nrPDB Length = 365 Score = 29.3 bits (64), Expect = 6.4, Method: Compositional matrix adjust. Identities = 14/48 (29%), Positives = 23/48 (47%) Query: 596 INNDPLVGDKLKVVFLPDYCVSAAEKLIPAADISEQISTAGKEASGTG 643 INN PLVG + ++F D + + A+D+ ++ G S G Sbjct: 64 INNRPLVGKNIAILFQKDSTRTRCAFEVAASDLGAGVTYIGPSGSNMG 111 >2F3D-A nrPDB Length = 338 Score = 29.3 bits (64), Expect = 7.3, Method: Compositional matrix adjust. Identities = 18/72 (25%), Positives = 32/72 (44%) Query: 89 QDSLKAYDINLTDLLEEEIDPALGNGGLGRLAACFLDSMATVGQSATGYGLNYQYGLFRQ 148 Q + D+ LT + EE A G G + +L ++ + + G+ + YG+ Sbjct: 4 QAAFDTNDVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGS 63 Query: 149 SFVDGKQVEAPD 160 + V G QV+ D Sbjct: 64 TNVTGDQVKKLD 75 >5NCK-A nrPDB Length = 291 Score = 28.9 bits (63), Expect = 8.3, Method: Compositional matrix adjust. Identities = 14/36 (38%), Positives = 21/36 (58%) Query: 506 ANKVRLAEFVKVRTGIEINPQAIFDIQIKRLHEYKR 541 A+ L VK RTG +N + IFD++ K + EY+ Sbjct: 171 ASTTALIRLVKERTGKTLNGKEIFDLEKKEILEYQE 206 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1AHP-A nrPDB 1284 0.0 5OX0-A nrPDB 1174 0.0 5IKP-A nrPDB 1166 0.0 2ZB2-A nrPDB 1155 0.0 4BQE-A nrPDB 1097 0.0 2C4M-A nrPDB 1044 0.0 1YGP-A nrPDB 1010 0.0 4L22-A nrPDB 915 0.0 5LR8-A nrPDB 624 e-179 Sequences not found previously or not previously below threshold: 4V8M-A0 nrPDB 36 0.073 5IM3-A nrPDB 34 0.23 5OPT-W nrPDB 34 0.23 3G33-B nrPDB 33 0.46 5OQM-l nrPDB 33 0.72 4NNP-A nrPDB 32 1.2 2X6Q-A nrPDB 32 1.2 2OND-A nrPDB 32 1.5 4M0K-A nrPDB 32 1.6 2OOE-A nrPDB 32 1.6 5NCK-A nrPDB 31 1.9 6NT9-A nrPDB 30 3.1 4I2Y-A nrPDB 30 3.7 2RGN-B nrPDB 30 4.0 4JLC-A nrPDB 30 4.2 2ZUE-A nrPDB 30 4.3 1WTH-A nrPDB 30 4.4 4MCR-A nrPDB 30 5.5 6O8B-A nrPDB 30 5.6 2I0Q-B nrPDB 30 6.3 1OTC-B nrPDB 29 7.6 1UAS-A nrPDB 29 9.3 CONVERGED! >1AHP-A nrPDB Length = 797 Score = 1284 bits (3324), Expect = 0.0, Method: Composition-based stats. Identities = 785/797 (98%), Positives = 788/797 (98%) Query: 1 MSQPIFNDKQFQEALSRQWQRYGLNSAAEMTPRQWWLAVSEALAEMLRAQPFAKPVANQR 60 MSQPIFNDKQFQEALSRQWQRYGLNSAAEMTPRQWWLAVSEALAEMLRAQPFAKPVANQR Sbjct: 1 MSQPIFNDKQFQEALSRQWQRYGLNSAAEMTPRQWWLAVSEALAEMLRAQPFAKPVANQR 60 Query: 61 HVNYISMEFLIGRLTGNNLLNLGWYQDVQDSLKAYDINLTDLLEEEIDPALGNGGLGRLA 120 HVNYISMEFLIGRLTGNNLLNLGWYQDVQDSLKAYDINLTDLLEEEIDPALG GGLGRLA Sbjct: 61 HVNYISMEFLIGRLTGNNLLNLGWYQDVQDSLKAYDINLTDLLEEEIDPALGAGGLGRLA 120 Query: 121 ACFLDSMATVGQSATGYGLNYQYGLFRQSFVDGKQVEAPDDWHRSNYPWFRHNEALDVQV 180 ACFLDSMATVGQSATGYGLNYQYGLFRQSFVDGKQVEAPDDWHRSNYPWFRHNEALDVQV Sbjct: 121 ACFLDSMATVGQSATGYGLNYQYGLFRQSFVDGKQVEAPDDWHRSNYPWFRHNEALDVQV 180 Query: 181 GIGGKVTKDGRWEPEFTITGQAWDLPVVGYRNGVAQPLRLWQATHAHPFDLTKFNDGDFL 240 GIGG VTKDGRWEPEFTITGQAWDLPVVGYRNGVAQPLRLWQATHAHPFDLTKFNDGDFL Sbjct: 181 GIGGAVTKDGRWEPEFTITGQAWDLPVVGYRNGVAQPLRLWQATHAHPFDLTKFNDGDFL 240 Query: 241 RAEQQGINAEKLTKVLYPNDNHTAGKKLRLMQQYFQCACSVADILRRHHLAGRKLHELAD 300 RAEQQGINAEKLTKVLYPNDNHTAGKKLRLMQQYFQCACSVADILRRHHLAGR+LHELAD Sbjct: 241 RAEQQGINAEKLTKVLYPNDNHTAGKKLRLMQQYFQCACSVADILRRHHLAGRELHELAD 300 Query: 301 YEVIQLNDTHPTIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKL 360 YEVIQLNDTHPTIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKL Sbjct: 301 YEVIQLNDTHPTIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKL 360 Query: 361 VKGLLPRHMQIINEINTRFKTLVEKTWPGDEKVWAKLAVVHDKQVHMANLCVVGGFAVNG 420 VKGLLPRHMQIINEINTRFKTLVEKTWPGDEKVWAKLAVVHDKQVHMANLCVVGGFAVNG Sbjct: 361 VKGLLPRHMQIINEINTRFKTLVEKTWPGDEKVWAKLAVVHDKQVHMANLCVVGGFAVNG 420 Query: 421 VAALHSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPALAALLDKSLQKEWAND 480 VAALHSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPALAALLDKSLQKEWAND Sbjct: 421 VAALHSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPALAALLDKSLQKEWAND 480 Query: 481 LDQLINLEKFADDAKFRQQYREIKQANKVRLAEFVKVRTGIEINPQAIFDIQIKRLHEYK 540 LDQLINL K ADDAKFR YR IKQANKVRLAEFVKVRTGI+INPQAIFDIQIKRLHEYK Sbjct: 481 LDQLINLVKLADDAKFRDLYRVIKQANKVRLAEFVKVRTGIDINPQAIFDIQIKRLHEYK 540 Query: 541 RQHLNLLHILALYKEIRENPQADRVPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDP 600 RQHLNLL ILALYKEIRENPQADRVPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDP Sbjct: 541 RQHLNLLRILALYKEIRENPQADRVPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDP 600 Query: 601 LVGDKLKVVFLPDYCVSAAEKLIPAADISEQISTAGKEASGTGNMKLALNGALTVGTLDG 660 LVGDKLKVVFLPDYCVSAAEKLIPAADISEQISTAGKEASGTGNMKLALNGALTVGTLDG Sbjct: 601 LVGDKLKVVFLPDYCVSAAEKLIPAADISEQISTAGKEASGTGNMKLALNGALTVGTLDG 660 Query: 661 ANVEIAEKVGEENIFIFGHTVEQVKAILAKGYDPVKWRKKDKVLDAVLKELESGKYSDGD 720 ANVEIAEKVGEENIFIFGHTV+QVKAILAKGYDPVKWRKKDKVLDAVLKELESGKYSDGD Sbjct: 661 ANVEIAEKVGEENIFIFGHTVKQVKAILAKGYDPVKWRKKDKVLDAVLKELESGKYSDGD 720 Query: 721 KHAFDQMLHSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRDQEAWTRAAILNTARCGMFS 780 KHAFDQMLHSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRDQEAWTRAAILNTARCGMFS Sbjct: 721 KHAFDQMLHSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRDQEAWTRAAILNTARCGMFS 780 Query: 781 SDRSIRDYQARIWQAKR 797 SDRSIRDYQARIWQA R Sbjct: 781 SDRSIRDYQARIWQAAR 797 >5OX0-A nrPDB Length = 843 Score = 1174 bits (3038), Expect = 0.0, Method: Composition-based stats. Identities = 349/788 (44%), Positives = 498/788 (63%), Gaps = 28/788 (3%) Query: 31 TPRQWWLAVSEALAEMLRAQPFAKPVANQRH--------VNYISMEFLIGRLTGNNLLNL 82 TPR ++ A LA +R + + Q+H + Y+S+EF +GR N ++NL Sbjct: 48 TPRDYYFA----LAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNL 103 Query: 83 GWYQDVQDSLKAYDINLTDLLEEEIDPALGNGGLGRLAACFLDSMATVGQSATGYGLNYQ 142 ++ +++ +L E E D LGNGGLGRLAACFLDSMAT+G +A GYG+ Y+ Sbjct: 104 ALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYE 163 Query: 143 YGLFRQSFVDGKQVEAPDDWHRSNYPWFRHNEALDVQVGIGGKV---TKDGRWEPEFTIT 199 +G+F Q G Q+E DDW R PW + + V G+V ++ +W + Sbjct: 164 FGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVL 223 Query: 200 GQAWDLPVVGYRNGVAQPLRLWQATHAHPFDLTKFNDGDFLRAEQQGINAEKLTKVLYPN 259 +D PV GYRN V +RLW A + F+L FN G +++A AE +++VLYPN Sbjct: 224 AMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPN 283 Query: 260 DNHTAGKKLRLMQQYFQCACSVADILRRHHLAG--------RKLHELADYEVIQLNDTHP 311 DN GK+LRL Q+YF A ++ DI+RR + D IQLNDTHP Sbjct: 284 DNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHP 343 Query: 312 TIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQI 371 ++AIPEL+RVL+D ++ WD AW +T KT AYTNHT++PEALERW V L++ LLPRH+QI Sbjct: 344 SLAIPELMRVLVDLERLDWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQI 403 Query: 372 INEINTRFKTLVEKTWPGDEKVWAKLAVVHD---KQVHMANLCVVGGFAVNGVAALHSDL 428 I EIN RF V +PGD ++++V + K+++MA+LC+ G AVNGVA +HS++ Sbjct: 404 IYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEI 463 Query: 429 VVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPALAALLDKSLQKEWANDLDQLINLE 488 + K +F ++++L P+KF N TNGITPRRW+ CNP LA ++ + + +E+ +DLDQL L Sbjct: 464 LKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLL 523 Query: 489 KFADDAKFRQQYREIKQANKVRLAEFVKVRTGIEINPQAIFDIQIKRLHEYKRQHLNLLH 548 + DD F + ++KQ NK++ A +++ + INP ++FD+Q+KR+HEYKRQ LN LH Sbjct: 524 SYVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLH 583 Query: 549 ILALYKEIRENPQADRVPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDPLVGDKLKV 608 ++ LY I++ P VPR + G KAAPGY++AK II I + DV+N+DP+VGD+L+V Sbjct: 584 VITLYNRIKKEPNKFVVPRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRV 643 Query: 609 VFLPDYCVSAAEKLIPAADISEQISTAGKEASGTGNMKLALNGALTVGTLDGANVEIAEK 668 +FL +Y VS AEK+IPAAD+SEQISTAG EASGTGNMK LNGALT+GT+DGANVE+AE+ Sbjct: 644 IFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEE 703 Query: 669 VGEENIFIFGHTVEQVKAILAKGYDPVKWRKKDKVLDAVLKELESGKYSDGDKHAFDQML 728 GEEN FIFG VE V + +GY+ ++ + L ++++L SG +S F ++ Sbjct: 704 AGEENFFIFGMRVEDVDRLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIV 763 Query: 729 HSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRDQEAWTRAAILNTARCGMFSSDRSIRDY 788 + + D + V AD+ YV+ Q++V LY++ WTR I N A G FSSDR+I Y Sbjct: 764 NMLMHH--DRFKVFADYEEYVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQY 821 Query: 789 QARIWQAK 796 IW + Sbjct: 822 AREIWGVE 829 >5IKP-A nrPDB Length = 846 Score = 1166 bits (3016), Expect = 0.0, Method: Composition-based stats. Identities = 351/788 (44%), Positives = 497/788 (63%), Gaps = 28/788 (3%) Query: 31 TPRQWWLAVSEALAEMLRAQPFAKPVANQRH--------VNYISMEFLIGRLTGNNLLNL 82 TPR ++ A LA +R + + Q+H + Y+S+EF +GR N ++NL Sbjct: 51 TPRDYFFA----LAHTVRDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRTLQNTMVNL 106 Query: 83 GWYQDVQDSLKAYDINLTDLLEEEIDPALGNGGLGRLAACFLDSMATVGQSATGYGLNYQ 142 G +++ ++L +L E E D LGNGGLGRLAACFLDSMAT+G +A GYG+ Y+ Sbjct: 107 GLQNACDEAIYQLGLDLEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYE 166 Query: 143 YGLFRQSFVDGKQVEAPDDWHRSNYPWFRHNEALDVQVGIGGKV--TKDG-RWEPEFTIT 199 +G+F Q V+G QVE DDW R PW + + V G+V T DG +W + Sbjct: 167 FGIFNQKIVNGWQVEEADDWLRYGNPWEKARPEYMLPVHFYGRVEHTPDGVKWLDTQVVL 226 Query: 200 GQAWDLPVVGYRNGVAQPLRLWQATHAHPFDLTKFNDGDFLRAEQQGINAEKLTKVLYPN 259 +D PV GY+N +RLW A + F L FN GD++ A AE +++VLYPN Sbjct: 227 AMPYDTPVPGYKNNTVNTMRLWSAKAPNDFKLQDFNVGDYIEAVLDRNLAENISRVLYPN 286 Query: 260 DNHTAGKKLRLMQQYFQCACSVADILRRHHLAG-------RKLHE-LADYEVIQLNDTHP 311 DN GK+LRL Q+YF A ++ DI+RR + R E D IQLNDTHP Sbjct: 287 DNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTCFETFPDKVAIQLNDTHP 346 Query: 312 TIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQI 371 ++IPEL+R+L+D ++ WD AW IT KT AYTNHT++PEALERW V + + LLPRH++I Sbjct: 347 ALSIPELMRILVDVEKVDWDKAWEITKKTCAYTNHTVLPEALERWPVSMFEKLLPRHLEI 406 Query: 372 INEINTRFKTLVEKTWPGDEKVWAKLAVVHD---KQVHMANLCVVGGFAVNGVAALHSDL 428 I IN R V +PGD +++V+ + K+++MA+LCV+G AVNGVA +HS++ Sbjct: 407 IYAINQRHLDHVAALFPGDVDRLRRMSVIEEGDCKRINMAHLCVIGSHAVNGVARIHSEI 466 Query: 429 VVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPALAALLDKSLQKEWANDLDQLINLE 488 V + +F ++++L P KF N TNGITPRRW+ CNP LA + + + +E+ DL QL L Sbjct: 467 VKQSVFKDFYELEPEKFQNKTNGITPRRWLLLCNPGLADTIVEKIGEEFLTDLSQLKKLL 526 Query: 489 KFADDAKFRQQYREIKQANKVRLAEFVKVRTGIEINPQAIFDIQIKRLHEYKRQHLNLLH 548 D F + ++KQ NK++ + F++ ++INP ++FD+ +KR+HEYKRQ LN LH Sbjct: 527 PLVSDEVFIRDVAKVKQENKLKFSAFLEKEYKVKINPSSMFDVHVKRIHEYKRQLLNCLH 586 Query: 549 ILALYKEIRENPQADRVPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDPLVGDKLKV 608 ++ LY I+ +P VPR + G KAAPGY++AK II + + DV+N+DP+VGD+LKV Sbjct: 587 VVTLYNRIKRDPAKAFVPRTVMIGGKAAPGYHMAKLIIKLVTSIGDVVNHDPVVGDRLKV 646 Query: 609 VFLPDYCVSAAEKLIPAADISEQISTAGKEASGTGNMKLALNGALTVGTLDGANVEIAEK 668 +FL +Y VS AEK+IPAAD+S+QISTAG EASGTGNMK LNGALT+GT+DGANVE+AE+ Sbjct: 647 IFLENYRVSLAEKVIPAADLSQQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEE 706 Query: 669 VGEENIFIFGHTVEQVKAILAKGYDPVKWRKKDKVLDAVLKELESGKYSDGDKHAFDQML 728 G EN+FIFG VE V+A+ KGY+ ++ L + ++ SG +S + F ++ Sbjct: 707 AGAENLFIFGLRVEDVEALDRKGYNAREYYDHLPELKQAVDQISSGFFSPKEPDCFKDIV 766 Query: 729 HSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRDQEAWTRAAILNTARCGMFSSDRSIRDY 788 + + D + V AD+ AY++ Q QVD LYR+ + WT+ I N A G FSSDR+I +Y Sbjct: 767 NMLMHH--DRFKVFADYEAYMQCQAQVDQLYRNPKEWTKKVIRNIACSGKFSSDRTITEY 824 Query: 789 QARIWQAK 796 IW + Sbjct: 825 AREIWGVE 832 >2ZB2-A nrPDB Length = 849 Score = 1155 bits (2989), Expect = 0.0, Method: Composition-based stats. Identities = 349/788 (44%), Positives = 497/788 (63%), Gaps = 28/788 (3%) Query: 31 TPRQWWLAVSEALAEMLRAQPFAKPVANQRH--------VNYISMEFLIGRLTGNNLLNL 82 T R ++ A LA +R + + Q+H V Y+S+EF +GR N ++NL Sbjct: 50 TTRDYYFA----LAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINL 105 Query: 83 GWYQDVQDSLKAYDINLTDLLEEEIDPALGNGGLGRLAACFLDSMATVGQSATGYGLNYQ 142 G +++ +++ +L E E D LGNGGLGRLAACFLDSMAT+G +A GYG+ Y+ Sbjct: 106 GLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYE 165 Query: 143 YGLFRQSFVDGKQVEAPDDWHRSNYPWFRHNEALDVQVGIGGKV---TKDGRWEPEFTIT 199 YG+F Q DG QVE DDW R PW + + V GKV +W + Sbjct: 166 YGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVL 225 Query: 200 GQAWDLPVVGYRNGVAQPLRLWQATHAHPFDLTKFNDGDFLRAEQQGINAEKLTKVLYPN 259 +D PV GY N +RLW A + F+L FN GD+++A AE +++VLYPN Sbjct: 226 ALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPN 285 Query: 260 DNHTAGKKLRLMQQYFQCACSVADILRRHHL--------AGRKLHELADYEVIQLNDTHP 311 DN GK+LRL Q+YF A ++ DI+RR AG D IQLNDTHP Sbjct: 286 DNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHP 345 Query: 312 TIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQI 371 +AIPEL+R+ +D ++ W AW +T KTFAYTNHT++PEALERW V LV+ LLPRH++I Sbjct: 346 ALAIPELMRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEI 405 Query: 372 INEINTRFKTLVEKTWPGDEKVWAKLAVVHD---KQVHMANLCVVGGFAVNGVAALHSDL 428 I EIN + + +P D +++++ + K+++MA+LC+VG AVNGVA +HSD+ Sbjct: 406 IYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDI 465 Query: 429 VVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPALAALLDKSLQKEWANDLDQLINLE 488 V +F ++ +L P+KF N TNGITPRRW+ CNP LA L+ + + +++ DL QL L Sbjct: 466 VKTKVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLH 525 Query: 489 KFADDAKFRQQYREIKQANKVRLAEFVKVRTGIEINPQAIFDIQIKRLHEYKRQHLNLLH 548 F D F ++ ++KQ NK++ ++F++ ++INP ++FD+Q+KR+HEYKRQ LN LH Sbjct: 526 SFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLH 585 Query: 549 ILALYKEIRENPQADRVPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDPLVGDKLKV 608 ++ +Y I+++P+ VPR + G KAAPGY++AK II I VADV+NNDP+VG KLKV Sbjct: 586 VITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKV 645 Query: 609 VFLPDYCVSAAEKLIPAADISEQISTAGKEASGTGNMKLALNGALTVGTLDGANVEIAEK 668 +FL +Y VS AEK+IPA D+SEQISTAG EASGTGNMK LNGALT+GT+DGANVE+AE+ Sbjct: 646 IFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEE 705 Query: 669 VGEENIFIFGHTVEQVKAILAKGYDPVKWRKKDKVLDAVLKELESGKYSDGDKHAFDQML 728 GEEN+FIFG ++ V A+ KGY+ ++ + L V+ ++++G +S F ++ Sbjct: 706 AGEENLFIFGMRIDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDII 765 Query: 729 HSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRDQEAWTRAAILNTARCGMFSSDRSIRDY 788 + + D + V AD+ AYV+ Q +V LY + +AW + N A G FSSDR+I++Y Sbjct: 766 NMLFYH--DRFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEY 823 Query: 789 QARIWQAK 796 IW + Sbjct: 824 AQNIWNVE 831 >4BQE-A nrPDB Length = 874 Score = 1097 bits (2836), Expect = 0.0, Method: Composition-based stats. Identities = 341/782 (43%), Positives = 475/782 (60%), Gaps = 29/782 (3%) Query: 42 ALAEMLRAQPFAKPVAN--------QRHVNYISMEFLIGRLTGNNLLNLGWYQDVQDSLK 93 A AE LR + + Y+SME+L GR N + NL D+L+ Sbjct: 90 ATAESLRDRLIQLWNETYVHFNKVDPKQTYYLSMEYLQGRALTNAIGNLNLQGPYADALR 149 Query: 94 AYDINLTDLLEEEIDPALGNGGLGRLAACFLDSMATVGQSATGYGLNYQYGLFRQSFVDG 153 L ++ E+E D ALGNGGLGRLA+CFLDSMAT+ A GYGL Y++GLF+Q Sbjct: 150 TLGYELEEIAEQEKDAALGNGGLGRLASCFLDSMATLNLPAWGYGLRYRHGLFKQIITKK 209 Query: 154 KQVEAPDDWHRSNYPWFRHNEALDVQVGIGGKV--TKDG--RWEPEFTITGQAWDLPVVG 209 Q E P+DW PW + V GKV DG +W + A+D+P+ G Sbjct: 210 GQEEIPEDWLEKFSPWEIVRHDVVFPVRFFGKVQVNPDGSRKWVDGDVVQALAYDVPIPG 269 Query: 210 YRNGVAQPLRLWQATH-AHPFDLTKFNDGDFLRAEQQGINAEKLTKVLYPNDNHTAGKKL 268 Y LRLW+A A DL +FN+G++ A Q A+++ VLYP D GK L Sbjct: 270 YGTKNTISLRLWEAKARAEDLDLFQFNEGEYELAAQLHSRAQQICTVLYPGDATENGKLL 329 Query: 269 RLMQQYFQCACSVADILRRHHLAG-----RKLHELADYEVIQLNDTHPTIAIPELLRVLI 323 RL QQ+F C+ S+ DI+ R H RK E +Q+NDTHPT+AIPEL+R+L+ Sbjct: 330 RLKQQFFLCSASLQDIISRFHERSTTEGSRKWSEFPSKVAVQMNDTHPTLAIPELMRLLM 389 Query: 324 DEHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQIINEINTRFKTLV 383 D++ + WD+AW +TSKT AYTNHT++PEALE+W L+ LLPRHM+II EI+ RF + Sbjct: 390 DDNGLGWDEAWDVTSKTVAYTNHTVLPEALEKWSQSLMWKLLPRHMEIIEEIDKRFVQTI 449 Query: 384 EKTWPGDEKVWAKLAVVHDKQ----VHMANLCVVGGFAVNGVAALHSDLVVKDLFPEYHQ 439 T E + L+++ + V MANLCVV VNGVA LHSD++ +LF +Y Sbjct: 450 RDTRVDLEDKISSLSILDNNPQKPVVRMANLCVVSSHTVNGVAQLHSDILKAELFADYVS 509 Query: 440 LWPNKFHNVTNGITPRRWIKQCNPALAALLDKSLQKE-WANDLDQLINLEKFADDAKFRQ 498 +WPNKF N TNGITPRRW++ C+P L+ ++ K L+ + W DLD L L +FAD+ + + Sbjct: 510 IWPNKFQNKTNGITPRRWLRFCSPELSDIITKWLKTDKWITDLDLLTGLRQFADNEELQS 569 Query: 499 QYREIKQANKVRLAEFVKVRTGIEINPQAIFDIQIKRLHEYKRQHLNLLHILALYKEIRE 558 ++ K ANK RLA++++ TG+ I+P ++FDIQ+KR+HEYKRQ +N+L ++ +K+++E Sbjct: 570 EWASAKTANKKRLAQYIERVTGVSIDPTSLFDIQVKRIHEYKRQLMNILGVVYRFKKLKE 629 Query: 559 NPQADR---VPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDPLVGDKLKVVFLPDYC 615 +R VPR + G KA Y AK I+ +N V DV+N+DP V + LKVVF+P+Y Sbjct: 630 MKPEERKKTVPRTVMIGGKAFATYTNAKRIVKLVNDVGDVVNSDPEVNEYLKVVFVPNYN 689 Query: 616 VSAAEKLIPAADISEQISTAGKEASGTGNMKLALNGALTVGTLDGANVEIAEKVGEENIF 675 V+ AE LIP +++S+ ISTAG EASGT NMK ALNG L +GTLDGANVEI E+VGEEN F Sbjct: 690 VTVAEMLIPGSELSQHISTAGMEASGTSNMKFALNGCLIIGTLDGANVEIREEVGEENFF 749 Query: 676 IFGHTVEQVKAILAKGYDPVKWRKKDKVLDAVLKELESGKYSDGDKHA-FDQMLHSIGKQ 734 +FG T +QV + + D K D + + ++SG + D D + + G Sbjct: 750 LFGATADQVPRLRKEREDG--LFKPDPRFEEAKQFVKSGVFGSYDYGPLLDSLEGNTGFG 807 Query: 735 GGDPYLVMADFAAYVEAQKQVDVLYRDQEAWTRAAILNTARCGMFSSDRSIRDYQARIWQ 794 GD +LV DF +Y++AQ +VD Y+D++ W + +IL+TA G FSSDR+I Y IW Sbjct: 808 RGDYFLVGYDFPSYMDAQAKVDEAYKDRKGWLKMSILSTAGSGKFSSDRTIAQYAKEIWN 867 Query: 795 AK 796 + Sbjct: 868 IE 869 >2C4M-A nrPDB Length = 796 Score = 1044 bits (2701), Expect = 0.0, Method: Composition-based stats. Identities = 350/778 (44%), Positives = 476/778 (61%), Gaps = 29/778 (3%) Query: 31 TPRQWWLAVSEALAEML-----RAQPFAKPVANQRHVNYISMEFLIGRLTGNNLLNLGWY 85 T R++W +S A+ E + R + A A Q+H Y S EFL+GR NNL NLG Sbjct: 29 TDRKFWTGLSRAVQERIADDWERTRE-AYGAARQQH--YFSAEFLMGRALLNNLTNLGLV 85 Query: 86 QDVQDSLKAYDINLTDLLEEEIDPALGNGGLGRLAACFLDSMATVGQSATGYGLNYQYGL 145 + + + LTD+LE E D ALGNGGLGRLAACFLDS T TGYGL Y++GL Sbjct: 86 DEAAAATRELGHELTDILEIENDAALGNGGLGRLAACFLDSAVTQDYPVTGYGLLYRFGL 145 Query: 146 FRQSFVDGKQVEAPDDWHRSNYPWFRHNEALDVQVGIGGKVTKDGRWEPEFTITGQAWDL 205 FRQSF +G QVE PD W YP+ + + V T+ +D+ Sbjct: 146 FRQSFNEGFQVEKPDPWREEEYPFTIRRASDQLVVCFDDMKTR-----------AIPYDM 194 Query: 206 PVVGYRNGVAQPLRLWQATHAHPFDLTKFNDGDFLRAEQQGINAEKLTKVLYPNDNHTAG 265 P+ GY LRLW+A FD FN F A + + +VLYPND G Sbjct: 195 PITGYGTHNVGTLRLWKAEPWEEFDYDAFNAQRFTDAIIERERVSDICRVLYPNDTTYEG 254 Query: 266 KKLRLMQQYFQCACSVADILRRHHLAGRKLHELADYEVIQLNDTHPTIAIPELLRVLIDE 325 KKLR+ QQYF + S+ +++ H + L A++ +QLNDTHP +AIPEL+R+L+DE Sbjct: 255 KKLRVRQQYFFTSASLQAMIQDHLAHHKDLSNFAEFHSVQLNDTHPVLAIPELMRLLMDE 314 Query: 326 HQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQIINEINTRFKTLVEK 385 H M W+++WAI SKTFAYTNHT++ EALE+WD ++ + L R +II EI+ RF +E+ Sbjct: 315 HDMGWEESWAIVSKTFAYTNHTVLTEALEQWDEQIFQQLFWRVWEIIAEIDRRF--RLER 372 Query: 386 TWPG-DEKVWAKLAVVHDKQVHMANLCVVGGFAVNGVAALHSDLVVKDLFPEYHQLWPNK 444 G DE+ ++A + VHMA + +++NGVAALH++++ + +++ LWP K Sbjct: 373 AADGLDEETINRMAPIQHGTVHMAWIACYAAYSINGVAALHTEIIKAETLADWYALWPEK 432 Query: 445 FHNVTNGITPRRWIKQCNPALAALLDK-SLQKEWANDLDQLINLEKFADDAKFRQQYREI 503 F+N TNG+TPRRW++ NP L+ LL + S +W DLD+L L +ADD ++ R I Sbjct: 433 FNNKTNGVTPRRWLRMINPGLSDLLTRLSGSDDWVTDLDELKKLRSYADDKSVLEELRAI 492 Query: 504 KQANKVRLAEFVKVRTGIEINPQAIFDIQIKRLHEYKRQHLNLLHILALYKEIRENPQAD 563 K ANK AE++ R GIEI+P++IFD+QIKRLHEYKRQ +N L++L LY I+E+ D Sbjct: 493 KAANKQDFAEWILERQGIEIDPESIFDVQIKRLHEYKRQLMNALYVLDLYFRIKEDGLTD 552 Query: 564 RVPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDPLVGDKLKVVFLPDYCVSAAEKLI 623 R +FGAKAAPGY AK II IN +AD++NNDP V LKVVF+ +Y VS AE ++ Sbjct: 553 IPARTVIFGAKAAPGYVRAKAIIKLINSIADLVNNDPEVSPLLKVVFVENYNVSPAEHIL 612 Query: 624 PAADISEQISTAGKEASGTGNMKLALNGALTVGTLDGANVEIAEKVGEENIFIFGHTVEQ 683 PA+D+SEQISTAGKEASGT NMK +NGALT+GT+DGANVEI + VGEEN +IFG VE+ Sbjct: 613 PASDVSEQISTAGKEASGTSNMKFMMNGALTLGTMDGANVEIVDSVGEENAYIFGARVEE 672 Query: 684 VKAILAKGYDPVKWRKKDKVLDAVLKELESGKYSDGDKHAFDQMLHSI----GKQGGDPY 739 + A+ + Y P + + L L L++G +D + F + HS+ GK D Y Sbjct: 673 LPAL-RESYKPYELYETVPGLKRALDALDNGTLNDNNSGLFYDLKHSLIHGYGKDASDTY 731 Query: 740 LVMADFAAYVEAQKQVDVLY-RDQEAWTRAAILNTARCGMFSSDRSIRDYQARIWQAK 796 V+ DFA Y E + ++ Y D W R A +N G FSSDR+IRDY IW+ + Sbjct: 732 YVLGDFADYRETRDRMAADYASDPLGWARMAWINICESGRFSSDRTIRDYATEIWKLE 789 >1YGP-A nrPDB Length = 879 Score = 1010 bits (2612), Expect = 0.0, Method: Composition-based stats. Identities = 346/811 (42%), Positives = 483/811 (59%), Gaps = 59/811 (7%) Query: 41 EALAEMLRAQPFAKPVANQR--------HVNYISMEFLIGRLTGNNLLNLGWYQD----- 87 EA + +R Q+ V Y+S+EFL+GR N L+N+ Sbjct: 70 EAASMSIRDNLVIDWNKTQQKFTTRDPKRVYYLSLEFLMGRALDNALINMKIEDPEDPAA 129 Query: 88 --------VQDSLKAYDINLTDLLEEEIDPALGNGGLGRLAACFLDSMATVGQSATGYGL 139 ++ +L L D+L++E D LGNGGLGRLAACF+DSMAT G A GYGL Sbjct: 130 SKGKPREMIKGALDELGFKLEDVLDQEPDAGLGNGGLGRLAACFVDSMATEGIPAWGYGL 189 Query: 140 NYQYGLFRQSFVDGKQVEAPDDWHRSNYPWFRHNEALDVQVGIGGKVTK---------DG 190 Y+YG+F Q +DG QVE PD W S PW + + V G V + Sbjct: 190 RYEYGIFAQKIIDGYQVETPDYWLNSGNPWEIERNEVQIPVTFYGYVDRPEGGKTTLSAS 249 Query: 191 RWEPEFTITGQAWDLPVVGYRNGVAQPLRLWQATHAHPFDLTKFNDGDFLRAEQQGINAE 250 +W + A+D PV G++ LRLWQA FDL KFN+GD+ + Q AE Sbjct: 250 QWIGGERVLAVAYDFPVPGFKTSNVNNLRLWQARPTTEFDLNKFNNGDYKNSVAQQQRAE 309 Query: 251 KLTKVLYPNDNHTAGKKLRLMQQYFQCACSVADILRRHHLAGRKLHELADYEVIQLNDTH 310 +T VLYPNDN GK+LRL QQYF CA S+ DILRR + R E D IQLNDTH Sbjct: 310 SITAVLYPNDNFAQGKELRLKQQYFWCAASLHDILRRFKKSKRPWTEFPDQVAIQLNDTH 369 Query: 311 PTIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQ 370 PT+AI EL RVL+D ++ W +AW I +KTFAYTNHT+M EALE+W +L LLPRH++ Sbjct: 370 PTLAIVELQRVLVDLEKLDWHEAWDIVTKTFAYTNHTVMQEALEKWPRRLFGHLLPRHLE 429 Query: 371 IINEINTRFKTLVEKTWPGDEKVWAKLAVVH----DKQVHMANLCVVGGFAVNGVAALHS 426 II +IN F V K +P D + ++++++ ++Q+ MA L +VG VNGV LHS Sbjct: 430 IIYDINWFFLEDVAKKFPKDVDLLSRISIIEENSPERQIRMAFLAIVGSHKVNGVVELHS 489 Query: 427 DLVVKDLFPEYHQLW-PNKFHNVTNGITPRRWIKQCNPALAALLDKSLQ---KEWANDLD 482 +L+ +F ++ + + P+KF NVTNGITPRRW+KQ NP+LA L+ ++L +E+ D+ Sbjct: 490 ELIKTTIFKDFIKFYGPSKFVNVTNGITPRRWLKQANPSLAKLISETLNDPTEEYLLDMA 549 Query: 483 QLINLEKFADDAKFRQQYREIKQANKVRLAEFVKVRT-GIEINP-----QAIFDIQIKRL 536 +L LEK+ +D +F +++ ++K NK+RL + +K G++I +FD+Q+KR+ Sbjct: 550 KLTQLEKYVEDKEFLKKWNQVKLNNKIRLVDLIKKENDGVDIINREYLDDTLFDMQVKRI 609 Query: 537 HEYKRQHLNLLHILALYKEIREN--------PQADRVPR-VFLFGAKAAPGYYLAKNIIF 587 HEYKRQ LN+ I+ Y ++ A + PR V +FG K+APGYY+AK II Sbjct: 610 HEYKRQQLNVFGIIYRYLAMKNMLKNGASIEEVARKYPRKVSIFGGKSAPGYYMAKLIIK 669 Query: 588 AINKVADVINNDPLVGDKLKVVFLPDYCVSAAEKLIPAADISEQISTAGKEASGTGNMKL 647 IN VAD++NND + LKVVF+ DY VS AE +IPA+D+SE ISTAG EASGT NMK Sbjct: 670 LINCVADIVNNDESIEHLLKVVFVADYNVSKAEIIIPASDLSEHISTAGTEASGTSNMKF 729 Query: 648 ALNGALTVGTLDGANVEIAEKVGEENIFIFGHTVEQVKAIL-AKGYDPVKWRKKDKVLDA 706 +NG L +GT+DGANVEI ++GE+N+F+FG+ E V+ + Y P + LD+ Sbjct: 730 VMNGGLIIGTVDGANVEITREIGEDNVFLFGNLSENVEELRYNHQYHP---QDLPSSLDS 786 Query: 707 VLKELESGKYSDGDKHAFDQMLHSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRDQE-AW 765 VL +ESG++S + + F ++ SI K GD YLV DF +Y+ + VD + +Q W Sbjct: 787 VLSYIESGQFSPENPNEFKPLVDSI-KYHGDYYLVSDDFESYLATHELVDQEFHNQRSEW 845 Query: 766 TRAAILNTARCGMFSSDRSIRDYQARIWQAK 796 + ++L+ A G FSSDR I +Y IW + Sbjct: 846 LKKSVLSLANVGFFSSDRCIEEYSDTIWNVE 876 >4L22-A nrPDB Length = 758 Score = 915 bits (2366), Expect = 0.0, Method: Composition-based stats. Identities = 288/790 (36%), Positives = 446/790 (56%), Gaps = 41/790 (5%) Query: 9 KQFQEALSRQWQRYGLNSAAEMTPRQWWLAVSEALAEMLRAQPFAKPVANQRHVNYISME 68 KQF + + ++ G N +++ ++ + + E + P ++R V YIS E Sbjct: 6 KQFSKYVQ---EKTGQN-LEQLSNEAIYVQLLHFVKEAAKDMPKN---TSKRKVYYISAE 58 Query: 69 FLIGRLTGNNLLNLGWYQDVQDSLKAYDINLTDLLEEEIDPALGNGGLGRLAACFLDSMA 128 FLIG+L NNL+NLG Y+ V+D L A +++ + + E++P+LGNGGLGRLA+CF+DSMA Sbjct: 59 FLIGKLLSNNLINLGLYKTVKDELAAAGKSISQVEDVELEPSLGNGGLGRLASCFIDSMA 118 Query: 129 TVGQSATGYGLNYQYGLFRQSFVDGKQVEAPDDWHRSNYPWFRHNEALDVQVGIGGKVTK 188 T+G + G GLNY GLF+Q F D +Q P+ W + W + ++ Sbjct: 119 TLGINGEGVGLNYHCGLFKQVFRDNQQEAEPNYWIEDD-SWL-----------VPTAISY 166 Query: 189 DGRWEPEFTITGQAWDLPVVGYRNGVAQPLRLWQATHAHPFDLTKFNDG-DFLRAEQQGI 247 D + FT+ + + ++GY L L+ D DG F + E + Sbjct: 167 DVPFRD-FTLKSKLDRIDILGYHKDSKNYLNLFDID---GLDYGLIKDGITFDKTEIK-- 220 Query: 248 NAEKLTKVLYPNDNHTAGKKLRLMQQYFQCACSVADILRRHHLAGRKLHELADYEVIQLN 307 + LT LYP+D+ G+ LR+ QQYF + + ++ G LH+LADY +Q+N Sbjct: 221 --KNLTLFLYPDDSDKNGELLRIYQQYFMVSNAAQLLIDEALERGSNLHDLADYAYVQIN 278 Query: 308 DTHPTIAIPELLRVLIDEHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKLVKGLLPR 367 DTHP++ IPEL+R+L ++H + + +A I YTNHT++ EALE+W ++ + ++P Sbjct: 279 DTHPSMVIPELIRLLNEKHGLDFYEAVDIVKNMIGYTNHTILAEALEKWPLEYLNEVVPH 338 Query: 368 HMQIINEINTRFKTLVEKTWPGDEKVWAKLAVVHDKQVHMANLCVVGGFAVNGVAALHSD 427 + II ++ +V + D A + D +VHMA++ + +VNGVAALH+D Sbjct: 339 LVTIIEHLDR----IVRSQYKDD----AVQIIDRDDRVHMAHMDIHFSTSVNGVAALHTD 390 Query: 428 LVVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPALAALLDKSLQKEWANDLDQLINL 487 ++ ++ ++P KF+N TNGIT RRW++ N LAA + + + + + D +L L Sbjct: 391 ILKNSELKPFYDIYPEKFNNKTNGITFRRWLEFANQDLAAYIKELIGEGYLEDATELEKL 450 Query: 488 EKFADDAKFRQQYREIKQANKVRLAEFVKVRTGIEINPQAIFDIQIKRLHEYKRQHLNLL 547 FADD +Q +IK NK+ L ++K GI ++ +I D QIKR HEYKRQ +N L Sbjct: 451 LAFADDKTVHEQLAKIKFNNKLALKRYLKENKGINLDENSIIDTQIKRFHEYKRQQMNAL 510 Query: 548 HILALYKEIRENPQADRVPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDPLVGDKLK 607 +++ Y EI++ R +FG KAAP Y +A++II I ++++INNDP V L Sbjct: 511 YVIYKYLEIKKGNLPKRKI-TVIFGGKAAPAYTIAQDIIHLILCLSELINNDPDVSPYLN 569 Query: 608 VVFLPDYCVSAAEKLIPAADISEQISTAGKEASGTGNMKLALNGALTVGTLDGANVEIAE 667 V + +Y V+ AEKLIPA DISEQIS A KEASGTGNMK LNGALT+GT+DGANVEIAE Sbjct: 570 VFLVENYNVTVAEKLIPATDISEQISLASKEASGTGNMKFMLNGALTLGTMDGANVEIAE 629 Query: 668 KVGEENIFIFGHTVEQVKAILAKG-YDPVKWRKKDKVLDAVLKEL-ESGKYSDGDKHAFD 725 VG +NI+IFG + + + KG Y + + V+ + + + G K + Sbjct: 630 LVGSDNIYIFGKDSDTIIDLYDKGTYVSKDYYTNNAVIKEAVDFIVSKDVLALGKKERLE 689 Query: 726 QMLHSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRDQEAWTRAAILNTARCGMFSSDRSI 785 ++ H + + D ++ + D Y+ ++++ Y DQ W + I N A+ G FSSDR+I Sbjct: 690 RLYHELINK--DWFMTLIDLKEYIAKKEEMLADYEDQNVWNKKVIQNIAKAGFFSSDRTI 747 Query: 786 RDYQARIWQA 795 + Y IW + Sbjct: 748 QQYDKDIWHS 757 >5LR8-A nrPDB Length = 938 Score = 624 bits (1610), Expect = e-179, Method: Composition-based stats. Identities = 197/455 (43%), Positives = 283/455 (62%), Gaps = 9/455 (1%) Query: 349 MPEALERWDVKLVKGLLPRHMQIINEINTRFKTLVEKTWPGDE-KVWAKLAVVHDKQVHM 407 + EA E+ + + V+ +L + E ++ EK P E +AK + V M Sbjct: 469 IAEADEKTESQEVENILSETTEKKAESDSEEAPDAEKEDPEYELDPFAKYDPQFPRVVRM 528 Query: 408 ANLCVVGGFAVNGVAALHSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNPALAA 467 ANLCVVGG +VNGVA +HS++V +D+F ++++WP KF N TNG+TPRRWI+ CNP L+ Sbjct: 529 ANLCVVGGHSVNGVAEIHSEIVKQDVFNSFYEMWPTKFQNKTNGVTPRRWIRFCNPELST 588 Query: 468 LLDKSLQ-KEWANDLDQLINLEKFADDAKFRQQYREIKQANKVRLAEFVKVRTGIEINPQ 526 ++ K + +W + D+L L+KFADD + ++R K+ NK+++ ++ +TG ++P Sbjct: 589 IISKWIGSDDWILNTDKLAGLKKFADDEDLQSEWRTAKRNNKMKVVSLIRDKTGYIVSPD 648 Query: 527 AIFDIQIKRLHEYKRQHLNLLHILALYKEIRENPQADR----VPRVFLFGAKAAPGYYLA 582 A+FD+Q+KR+HEYKRQ LN+L I+ YK+++E DR VPRV +FG KA Y A Sbjct: 649 AMFDVQVKRIHEYKRQLLNILGIVYRYKKMKEMSAKDRRKSFVPRVCIFGGKAFATYVQA 708 Query: 583 KNIIFAINKVADVINNDPLVGDKLKVVFLPDYCVSAAEKLIPAADISEQISTAGKEASGT 642 K I+ I VA +N DP +GD LKVVF+PDY VS AE LIPA+++S+ ISTAG EASGT Sbjct: 709 KRIVKFITDVAATVNYDPDIGDLLKVVFVPDYNVSVAETLIPASELSQHISTAGMEASGT 768 Query: 643 GNMKLALNGALTVGTLDGANVEIAEKVGEENIFIFGHTVEQVKAILAKGYDPVKWRKKDK 702 NMK A+NG L +GTLDGANVEI E+VGEEN F+FG ++ + + + D Sbjct: 769 SNMKFAMNGCLLIGTLDGANVEIREEVGEENFFLFGAHAPEIAGLRQERAEGK--FVPDL 826 Query: 703 VLDAVLKELESGKYSDGDKHAF-DQMLHSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRD 761 + V + + SG + + + + G D +LV DF +Y+E Q++VD YRD Sbjct: 827 RFEEVKEYVRSGVFGTSNYDELMGSLEGNEGYGRADYFLVGKDFPSYIECQEKVDEAYRD 886 Query: 762 QEAWTRAAILNTARCGMFSSDRSIRDYQARIWQAK 796 Q+ WTR +ILNTA FSSDR+I +Y IW Sbjct: 887 QKLWTRMSILNTAGSPKFSSDRTIHEYAKDIWDIS 921 Score = 491 bits (1263), Expect = e-139, Method: Composition-based stats. Identities = 147/362 (40%), Positives = 201/362 (55%), Gaps = 16/362 (4%) Query: 42 ALAEMLRAQPFAKPVA--------NQRHVNYISMEFLIGRLTGNNLLNLGWYQDVQDSLK 93 A A+ + A N + Y+SMEFL GR N + NL ++LK Sbjct: 59 ATAKSVFDSLIMNWNATYDYYNKVNAKQAYYLSMEFLQGRALTNAIGNLELTGQYAEALK 118 Query: 94 AYDINLTDLLEEEIDPALGNGGLGRLAACFLDSMATVGQSATGYGLNYQYGLFRQSFVDG 153 NL D+ +E DPALGNGGLGRLA+CFLDS+AT+ A GYGL Y+YGLF+Q Sbjct: 119 QLGHNLEDVASQEPDPALGNGGLGRLASCFLDSLATLNYPAWGYGLRYRYGLFKQIITKD 178 Query: 154 KQVEAPDDWHRSNYPWFRHNEALDVQVGIGGKVTK--DGR--WEPEFTITGQAWDLPVVG 209 Q E ++W PW + V GKV + DGR W I A D+P+ G Sbjct: 179 GQEEVAENWLEMGNPWEIVRNDVSYPVKFYGKVVEGTDGRKHWIGGENIKAVAHDVPIPG 238 Query: 210 YRNGVAQPLRLWQAT-HAHPFDLTKFNDGDFLRAEQQGINAEKLTKVLYPNDNHTAGKKL 268 Y+ LRLW T + FDL FN GD +A + +NAEK+ VLYP D + GK L Sbjct: 239 YKTKTTNNLRLWSTTVPSQNFDLGAFNAGDHAKANEAHLNAEKICHVLYPGDESSEGKIL 298 Query: 269 RLMQQYFQCACSVADILRRHHLA---GRKLHELADYEVIQLNDTHPTIAIPELLRVLIDE 325 RL QQY C+ S+ DI+ R + +Q+NDTHPT+ IPEL+R+L+D Sbjct: 299 RLKQQYTLCSASLQDIISRFESRAGDSLNWEDFPSKVAVQMNDTHPTLCIPELMRILMDI 358 Query: 326 HQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQIINEINTRFKTLVEK 385 +SW++AW+IT +T AYTNHT++PEALE+W + +++ LLPRH++II I+ + Sbjct: 359 KGLSWNEAWSITERTVAYTNHTVLPEALEKWSLDIMQKLLPRHVEIIETIDEELMNNIVS 418 Query: 386 TW 387 + Sbjct: 419 KY 420 >4V8M-A0 nrPDB Length = 256 Score = 35.8 bits (81), Expect = 0.073, Method: Composition-based stats. Identities = 20/77 (25%), Positives = 34/77 (44%), Gaps = 2/77 (2%) Query: 27 AAEMTPRQWWLAVSEALAEMLRAQPFAKPVANQRHVNYISMEFLIGRLTGNNLLNLGWYQ 86 A E R+ W V +R FAK + N+ I+ +FL GR+ NL +L Q Sbjct: 20 AQEAMSRKEWYDVVAPKNFEVR--QFAKTICNKTQGTKIAADFLRGRVYEGNLADLNKTQ 77 Query: 87 DVQDSLKAYDINLTDLL 103 + D+ + + ++ Sbjct: 78 NEDDAYRKVKFTVQEVQ 94 >5IM3-A nrPDB Length = 963 Score = 34.2 bits (77), Expect = 0.23, Method: Composition-based stats. Identities = 26/172 (15%), Positives = 62/172 (36%), Gaps = 14/172 (8%) Query: 404 QVHMANLCVVGGFAVNGVAALHSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWIKQCNP 463 + M L + A G+A + L+ ++ + K N T + R + + P Sbjct: 159 PLDMGRLNTIISEACEGLAEVDGALIERETLKNLYDGVAEKDVN-TALVMTARTLVEREP 217 Query: 464 ALAALLDKSLQKEWANDLDQLINLEKFADDAKFRQQYREIKQANKVRLAEFVKVRTGIEI 523 + + + L + + + + A + + Y + L +++ E+ Sbjct: 218 NYSYVTARLLMDTLRAEALGFLGVAESATHHEMAELYAKA-------LPAYIEKGAEFEL 270 Query: 524 NPQAI--FDIQI--KRLHEYKRQHLNLLHILALYKE--IRENPQADRVPRVF 569 + FD++ K + + Q L + LY I ++ +P++F Sbjct: 271 VDAKLKEFDLEKLGKAIDHERDQQFTYLGLQTLYDRYFIHKDGIRFELPQIF 322 >5OPT-W nrPDB Length = 261 Score = 34.2 bits (77), Expect = 0.23, Method: Composition-based stats. Identities = 18/77 (23%), Positives = 33/77 (42%), Gaps = 2/77 (2%) Query: 27 AAEMTPRQWWLAVSEALAEMLRAQPFAKPVANQRHVNYISMEFLIGRLTGNNLLNLGWYQ 86 A E R+ W V +R F K + N+ I+ ++L GR+ +NL +L Q Sbjct: 20 AQETMSRKEWYDVVAPKNFEVR--QFGKTICNKTQGTKIAADYLRGRVYESNLADLNKTQ 77 Query: 87 DVQDSLKAYDINLTDLL 103 D+ + + ++ Sbjct: 78 GDDDAYRKVKFVVQEVQ 94 >3G33-B nrPDB Length = 306 Score = 33.1 bits (74), Expect = 0.46, Method: Composition-based stats. Identities = 10/38 (26%), Positives = 16/38 (42%) Query: 337 TSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQIINE 374 K YT+H + P L W+V ++ L +I Sbjct: 135 IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAH 172 >5OQM-l nrPDB Length = 745 Score = 32.7 bits (73), Expect = 0.72, Method: Composition-based stats. Identities = 14/74 (18%), Positives = 29/74 (39%), Gaps = 8/74 (10%) Query: 718 DGDKHAFDQMLHSIGKQGGDPYLVMADFAAYVEAQKQVDVLYRDQEAWTRAAILNTARCG 777 +K +++++ I + DP L + +F + LY + + A G Sbjct: 342 PLNKPRLEKLINEILLKSNDPLLSLYNF---LHKYVLTLQLYMVHREFLK-----LANGG 393 Query: 778 MFSSDRSIRDYQAR 791 FS I +Y ++ Sbjct: 394 KFSKSNLIHNYDSK 407 >4NNP-A nrPDB Length = 291 Score = 31.9 bits (71), Expect = 1.2, Method: Composition-based stats. Identities = 31/138 (22%), Positives = 54/138 (39%), Gaps = 19/138 (13%) Query: 634 TAGKEASGTGNMKLALNGALTVGTLDGANVEIAEKVGEENIFIFGHTVEQVKAILAKGYD 693 T GK++S N G L V T + ++A+ VG +N+ + +I+ G D Sbjct: 2 TGGKQSSDKSN------GKLKVVTTNSILYDMAKNVGGDNV--------DIHSIVPVGQD 47 Query: 694 PVKWRKKDKVLDAVLKE---LESGKYSDGDKHAFDQMLHSIGKQGGDP--YLVMADFAAY 748 P ++ K K + + L +G + F++ L GK D V D Sbjct: 48 PHEYEVKPKDIKKLTDADVILYNGLNLETGNGWFEKALEQAGKSLKDKKVIAVSKDVKPI 107 Query: 749 VEAQKQVDVLYRDQEAWT 766 ++ + +D AW Sbjct: 108 YLNGEEGNKDKQDPHAWL 125 >2X6Q-A nrPDB Length = 416 Score = 31.9 bits (71), Expect = 1.2, Method: Composition-based stats. Identities = 34/232 (14%), Positives = 88/232 (37%), Gaps = 27/232 (11%) Query: 504 KQANKVRLAEFVKVRTGIEINPQAIFDIQIKRLHEYKRQHLNLLHILALYKEIRENPQAD 563 ++ +++ E +++ +++P+ Q+ R +K + ++ +Y++++E Sbjct: 208 EKNVELKQTEILRILERFDVDPEKPIITQVSRFDPWK----GIFDVIEIYRKVKEKIPGV 263 Query: 564 RVPRVFLFGAKAAPGYYLAKNIIFAINKVADVINNDPLVGDKLKVVFLPDYCVSAAEKLI 623 ++ V + G+ + + K+ + D V ++ + V+A ++ Sbjct: 264 QLLLVGVMAHDDPEGWIYFE---KTLRKIGE----DYDVKVLTNLIGVHAREVNAFQR-- 314 Query: 624 PAADISEQISTAGKEASGTGNMKLALNGALTVG-TLDGANVEIAEKVGEENIFIFGHT-- 680 A+D+ Q+S +E G + G +G + G +I + GE + Sbjct: 315 -ASDVILQMSI--REGFGLTVTEAMWKGKPVIGRAVGGIKFQIVD--GETGFLVRDANEA 369 Query: 681 VEQVKAILAKGYDPVKWRKKDKVLDAVLKELESGKYSDGDKHAFDQMLHSIG 732 VE V +L + K + + + +L+S+G Sbjct: 370 VEVVLYLLKHPEVSKEMGAK------AKERVRKNFIITKHMERYLDILNSLG 415 >2OND-A nrPDB Length = 308 Score = 31.5 bits (70), Expect = 1.5, Method: Composition-based stats. Identities = 17/80 (21%), Positives = 35/80 (43%), Gaps = 7/80 (8%) Query: 687 ILAKGYDPVKWRKKDKVLDAVLKEL-ESG------KYSDGDKHAFDQMLHSIGKQGGDPY 739 +L G+ P W + + L+ K L E G +SD + +++ + ++ K+ Y Sbjct: 43 LLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNMLLY 102 Query: 740 LVMADFAAYVEAQKQVDVLY 759 AD+ ++V +Y Sbjct: 103 FAYADYEESRMKYEKVHSIY 122 >4M0K-A nrPDB Length = 199 Score = 31.5 bits (70), Expect = 1.6, Method: Composition-based stats. Identities = 19/62 (30%), Positives = 28/62 (45%), Gaps = 3/62 (4%) Query: 263 TAGKKLRLMQQYFQCACSVADILRRHHLAGRKLHELADYEVIQLNDTHPTIAIPELLRVL 322 ++G L YFQ + A L A R + + + IQ D P + PELLR+ Sbjct: 8 SSGVDLGTENLYFQSMNATA--LETLKQAIRTVPDFPE-PGIQFKDITPVLGHPELLRLA 64 Query: 323 ID 324 I+ Sbjct: 65 IE 66 >2OOE-A nrPDB Length = 530 Score = 31.5 bits (70), Expect = 1.6, Method: Composition-based stats. Identities = 17/80 (21%), Positives = 35/80 (43%), Gaps = 7/80 (8%) Query: 687 ILAKGYDPVKWRKKDKVLDAVLKEL-ESG------KYSDGDKHAFDQMLHSIGKQGGDPY 739 +L G+ P W + + L+ K L E G +SD + +++ + ++ K+ Y Sbjct: 265 LLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNMLLY 324 Query: 740 LVMADFAAYVEAQKQVDVLY 759 AD+ ++V +Y Sbjct: 325 FAYADYEESRMKYEKVHSIY 344 >5NCK-A nrPDB Length = 291 Score = 31.2 bits (69), Expect = 1.9, Method: Composition-based stats. Identities = 14/37 (37%), Positives = 22/37 (59%) Query: 504 KQANKVRLAEFVKVRTGIEINPQAIFDIQIKRLHEYK 540 + A+ L VK RTG +N + IFD++ K + EY+ Sbjct: 169 QFASTTALIRLVKERTGKTLNGKEIFDLEKKEILEYQ 205 >6NT9-A nrPDB Length = 742 Score = 30.4 bits (67), Expect = 3.1, Method: Composition-based stats. Identities = 39/248 (15%), Positives = 84/248 (33%), Gaps = 30/248 (12%) Query: 266 KKLRLMQQYFQCACSVADILRRHHLAGRKLHELADYEVIQLNDTHPTIAIPELLRVLID- 324 K LRL S+ DI R G A E THP E L+VL++ Sbjct: 504 KLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEG-----THPKDRNVEKLQVLLNC 558 Query: 325 EHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQIINEINTRFKTLVE 384 ++ + + AY E + ++D + L + + E Sbjct: 559 MTEIYYQFKKDKAERRLAYNE-----EQIHKFDKQ---KLYYHATKAMTHFTDECVKKYE 610 Query: 385 KTWPGDEKVWAKLAVVHDKQVHMANLCVVGGFAVNGVAALHSDLVVKDLF-PEYHQLWPN 443 E+ K+ + + + + N C + ++ + E + P Sbjct: 611 AFLNKSEEWIRKMLHLRKQLLSLTNQCF----------DIEEEVSKYQEYTNELQETLPQ 660 Query: 444 KFHNVTNGITPRRWIKQCNPALAALLDKSLQKEWANDLDQLINLEK-FADDAKFRQQYRE 502 K ++GI + + P+ L++ +L + + ++ + K A++ +++ Sbjct: 661 KMFTASSGI--KHTMTPIYPSSNTLVEMTLGMKKLKE--EMEGVVKELAENNHILERFGS 716 Query: 503 IKQANKVR 510 + +R Sbjct: 717 LTMDGGLR 724 >4I2Y-A nrPDB Length = 421 Score = 30.0 bits (66), Expect = 3.7, Method: Composition-based stats. Identities = 11/63 (17%), Positives = 23/63 (36%), Gaps = 4/63 (6%) Query: 277 CACSVADILRRHHLAGRKLHELADYEVI---QLNDTHPTIAIPELLRVLIDEHQMSWDDA 333 + D++ G + ++ + ++NDT I E RV D+ + A Sbjct: 317 TEAELQDMINEVDADGDGTFDFPEFLTMMARKMNDTDSEEEIREAFRVF-DKDGNGYIGA 375 Query: 334 WAI 336 + Sbjct: 376 AEL 378 >2RGN-B nrPDB Length = 354 Score = 30.0 bits (66), Expect = 4.0, Method: Composition-based stats. Identities = 19/86 (22%), Positives = 35/86 (40%), Gaps = 5/86 (5%) Query: 322 LIDEHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQIINEINTRFKT 381 L++ +M DD I A +PE+L D + + Q I E + + Sbjct: 20 LVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNI-----QQIYEWHRDYFL 74 Query: 382 LVEKTWPGDEKVWAKLAVVHDKQVHM 407 + D A+L + H++++HM Sbjct: 75 QELQRCLKDPDWLAQLFIKHERRLHM 100 >4JLC-A nrPDB Length = 657 Score = 30.0 bits (66), Expect = 4.2, Method: Composition-based stats. Identities = 28/147 (19%), Positives = 50/147 (34%), Gaps = 14/147 (9%) Query: 266 KKLRLMQQYFQCACSVADILRRHHLAGRKLHELADYEVIQLNDTHPTIAIPELLRVLID- 324 K LRL S+ DI R G A E THP E L+VL++ Sbjct: 505 KLLRLSSSQGTIESSLQDISSRLSPGGLLADTWAHQEG-----THPRDRNVEKLQVLLNC 559 Query: 325 EHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQIINEINTRFKTLVE 384 ++ + + AY E + ++D + L + ++ + E Sbjct: 560 ITEIYYQFKKDKAERRLAYNE-----EQIHKFDKQ---KLYYHATKAMSHFSEECVRKYE 611 Query: 385 KTWPGDEKVWAKLAVVHDKQVHMANLC 411 E+ K+ + + + + N C Sbjct: 612 AFKDKSEEWMRKMLHLRKQLLSLTNQC 638 >2ZUE-A nrPDB Length = 629 Score = 30.0 bits (66), Expect = 4.3, Method: Composition-based stats. Identities = 24/133 (18%), Positives = 54/133 (40%), Gaps = 27/133 (20%) Query: 455 RRWIKQCNPALAAL----LDKSLQKEWANDLDQLINLEKFADDAKFRQQYREIKQANKVR 510 R I++ NPAL+ + + + NL K++ D K ++ ++ + Sbjct: 449 RELIEEKNPALSDEEKAEVAEKVGIGAIR-----YNLIKYSPDKKIIFRWEDV-LNFEGE 502 Query: 511 LAEFVK-------------VRTGIEINPQAIF-DIQIKRLHEYKRQHLNLLHILALYKEI 556 A +++ GI+++P+ +F + +L E +R+ + +L + + I Sbjct: 503 SAPYIQYAHARCSSILRKAEEEGIKVDPETLFKNADFTKLSERERELVIML---SKFPRI 559 Query: 557 RENPQADRVPRVF 569 E D P + Sbjct: 560 VEQAGKDVKPHLI 572 >1WTH-A nrPDB Length = 584 Score = 30.0 bits (66), Expect = 4.4, Method: Composition-based stats. Identities = 24/104 (23%), Positives = 39/104 (37%), Gaps = 10/104 (9%) Query: 1 MSQPIFNDKQFQEALSRQWQRYGLNSAAEMTPRQWWLAVSEALAEMLRA-------QPFA 53 M QP+ + Q + LS+Q R + +T + LA+M R P Sbjct: 207 MKQPVRDMAQINKVLSKQVGREITGNPGSITMEEATTLFERDLADMQRDIKSHSKVGPVW 266 Query: 54 KPVANQRHVNYISMEFLI---GRLTGNNLLNLGWYQDVQDSLKA 94 + V R + +M F + G N +L D + + KA Sbjct: 267 QAVNRSRQMALENMAFQMGVGGVAKFNTMLTAMLAGDWEKAYKA 310 >4MCR-A nrPDB Length = 757 Score = 29.6 bits (65), Expect = 5.5, Method: Composition-based stats. Identities = 20/71 (28%), Positives = 28/71 (39%), Gaps = 4/71 (5%) Query: 241 RAEQQGINAEKLTKVLYPNDNHTAGKKLRLMQQYFQCACSVADILRRHHLAGRKLHELAD 300 +A + AE + K LY N T L +Q FQ A + + L +L D Sbjct: 66 KAFLDELKAENIKKFLY---NFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHY-D 121 Query: 301 YEVIQLNDTHP 311 + N THP Sbjct: 122 VLLSYPNKTHP 132 >6O8B-A nrPDB Length = 665 Score = 29.6 bits (65), Expect = 5.6, Method: Composition-based stats. Identities = 28/147 (19%), Positives = 48/147 (32%), Gaps = 14/147 (9%) Query: 266 KKLRLMQQYFQCACSVADILRRHHLAGRKLHELADYEVIQLNDTHPTIAIPELLRVLID- 324 K LRL S+ DI R G A E THP E L+VL++ Sbjct: 512 KLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEG-----THPKDRNVEKLQVLLNC 566 Query: 325 EHQMSWDDAWAITSKTFAYTNHTLMPEALERWDVKLVKGLLPRHMQIINEINTRFKTLVE 384 ++ + + AY E + ++D + L + + E Sbjct: 567 MTEIYYQFKKDQAERRLAYNE-----EQIHKFDKQ---KLYYHATKAMTHFTDECVKKYE 618 Query: 385 KTWPGDEKVWAKLAVVHDKQVHMANLC 411 E+ K+ + + + + N C Sbjct: 619 AFLNKSEEWIRKMLHLRKQLLSLTNQC 645 >2I0Q-B nrPDB Length = 385 Score = 29.6 bits (65), Expect = 6.3, Method: Composition-based stats. Identities = 7/41 (17%), Positives = 16/41 (39%) Query: 711 LESGKYSDGDKHAFDQMLHSIGKQGGDPYLVMADFAAYVEA 751 + G + + AF Q+ + GD V ++ ++ Sbjct: 1 MSKGASAPQQQSAFKQLYTELFNNEGDFSKVSSNLKKPLKC 41 >1OTC-B nrPDB Length = 260 Score = 29.2 bits (64), Expect = 7.6, Method: Composition-based stats. Identities = 7/41 (17%), Positives = 16/41 (39%) Query: 711 LESGKYSDGDKHAFDQMLHSIGKQGGDPYLVMADFAAYVEA 751 + G + + AF Q+ + GD V ++ ++ Sbjct: 1 MSKGASAPQQQSAFKQLYTELFNNEGDFSKVSSNLKKPLKC 41 >1UAS-A nrPDB Length = 362 Score = 28.8 bits (63), Expect = 9.3, Method: Composition-based stats. Identities = 11/45 (24%), Positives = 20/45 (44%) Query: 5 IFNDKQFQEALSRQWQRYGLNSAAEMTPRQWWLAVSEALAEMLRA 49 ++N + +Q ++ W GL + +T R W S A + A Sbjct: 303 LWNRQSYQATITAHWSNIGLAGSVAVTARDLWAHSSFAAQGQISA 347 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.313 0.137 0.390 Lambda K H 0.267 0.0416 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 32,819,981 Number of Sequences: 36641 Number of extensions: 1375678 Number of successful extensions: 3946 Number of sequences better than 10.0: 40 Number of HSP's better than 10.0 without gapping: 34 Number of HSP's successfully gapped in prelim test: 33 Number of HSP's that attempted gapping in prelim test: 3797 Number of HSP's gapped (non-prelim): 78 length of query: 797 length of database: 10,336,785 effective HSP length: 105 effective length of query: 692 effective length of database: 6,489,480 effective search space: 4490720160 effective search space used: 4490720160 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 63 (28.9 bits)