BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P00452 (761 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5R1R-A nrPDB 1587 0.0 5IM3-A nrPDB 277 2e-74 5D1Y-A nrPDB 243 2e-64 2ZLF-A nrPDB 241 7e-64 2WGH-A nrPDB 219 3e-57 6CGM-A nrPDB 151 1e-36 1PEQ-A nrPDB 142 5e-34 6DQW-A nrPDB 107 3e-23 6DQX-A nrPDB 100 3e-21 3O0O-A nrPDB 97 2e-20 3SDU-A nrPDB 35 0.14 4HSC-X nrPDB 32 1.0 6O9P-A nrPDB 31 2.1 4FE1-B nrPDB 30 3.2 3R42-A nrPDB 29 9.8 >5R1R-A nrPDB Length = 761 Score = 1587 bits (4109), Expect = 0.0, Method: Compositional matrix adjust. Identities = 760/761 (99%), Positives = 760/761 (99%) Query: 1 MNQNLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGIKTSDIHE 60 MNQNLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGIKTSDIHE Sbjct: 1 MNQNLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGIKTSDIHE 60 Query: 61 TIIKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDNHLL 120 TIIKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDNHLL Sbjct: 61 TIIKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDNHLL 120 Query: 121 EDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACL 180 EDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACL Sbjct: 121 EDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACL 180 Query: 181 FSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINAT 240 FSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINAT Sbjct: 181 FSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINAT 240 Query: 241 SSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGG 300 SSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGG Sbjct: 241 SSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGG 300 Query: 301 AATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSD 360 AATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSD Sbjct: 301 AATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSD 360 Query: 361 VPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHC 420 VPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHC Sbjct: 361 VPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHC 420 Query: 421 NTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAINNLDELEE 480 NTHSPFDPAIAPVRQSNLCL IALPTKPLNDVNDENGEIALCTLSAFNLGAINNLDELEE Sbjct: 421 NTHSPFDPAIAPVRQSNLCLAIALPTKPLNDVNDENGEIALCTLSAFNLGAINNLDELEE 480 Query: 481 LAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLT 540 LAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLT Sbjct: 481 LAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLT 540 Query: 541 HKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWE 600 HKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWE Sbjct: 541 HKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWE 600 Query: 601 ALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDYE 660 ALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDYE Sbjct: 601 ALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDYE 660 Query: 661 HLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLT 720 HLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLT Sbjct: 661 HLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLT 720 Query: 721 AYKFGVKTLYYQNTRDGAEDAQDDLVPSIQDDGCESGACKI 761 AYKFGVKTLYYQNTRDGAEDAQDDLVPSIQDDGCESGACKI Sbjct: 721 AYKFGVKTLYYQNTRDGAEDAQDDLVPSIQDDGCESGACKI 761 >5IM3-A nrPDB Length = 963 Score = 277 bits (708), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 203/686 (29%), Positives = 319/686 (46%), Gaps = 57/686 (8%) Query: 4 NLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGIKTSDIHETII 63 ++ +T+ DGS +++ +++ ++ A EGL V + +E + YDG+ D++ ++ Sbjct: 147 SIRITRADGSLSPLDMGRLNTIISEACEGLAEVDGALIERETLKNLYDGVAEKDVNTALV 206 Query: 64 KAAADLISRDAPDYQYLAARLAIFHLRKKAYG--------------QFEPPALYDHVVKM 109 A L+ R+ P+Y Y+ ARL + LR +A G + AL ++ K Sbjct: 207 MTARTLVERE-PNYSYVTARLLMDTLRAEALGFLGVAESATHHEMAELYAKALPAYIEKG 265 Query: 110 VEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESA 169 E D L E + +++ IDH+RD F+Y ++ L +Y + G +E Sbjct: 266 AEFELVDAKL----KEFDLEKLGKAIDHERDQQFTYLGLQTLYDRYFIHK--DGIRFELP 319 Query: 170 QFLYILVAACL-FSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLI 228 Q ++ VA L RE R FY+ +S+F TP + T Q SSC L Sbjct: 320 QIFFMRVAMGLAIEEKDREAR---AIEFYNLLSSFDYMSSTPTLFNAGTLRPQLSSCYLT 376 Query: 229 ECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTA 288 D L I G+G + +RALGS I+G G +PF K Sbjct: 377 TVPDDLSGIYGAIHDNAMLSKFAGGLGNDWTPVRALGSYIKGTNGKSQGVVPFLKVVNDT 436 Query: 289 VKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLL 348 + +QGG R GA + WHL++E L L+ N G + R M+ I L R+ Sbjct: 437 AVAVNQGGKRKGAVCAYLETWHLDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVF 496 Query: 349 KGEDITLFSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQR----VKAVELFSLMMQ 404 TLFSPSDVP L+D + + FE Y YE S K + V+A +L+ M+ Sbjct: 497 DDGSWTLFSPSDVPDLHDLY---GKAFEERYEYYEALASYGKLKLHKVVQAKDLWRKMLS 553 Query: 405 ERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTL 464 TG ++ D CN SP + V SNLC EI L N EIA+C L Sbjct: 554 MLFETGHPWLTFKDPCNLRSP-QQHVGVVHSSNLCTEITL--------NTNKDEIAVCNL 604 Query: 465 SAFNLGAINNL-------DELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGV 517 + NL +N++ +LE+ AVR LD ++D Y +P A+ R +G+G+ Sbjct: 605 GSINL--VNHIVDGKLDTAKLEKTVKTAVRMLDNVIDINYYSVPQAQNSNFKHRPVGLGI 662 Query: 518 INFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGI 577 + F L Y +A ++ EAI YY ++AS +LA E+GA F + +++GI Sbjct: 663 MGFQDALYLQHIPYGSDAAIAFADQSMEAISYYAIQASCDLADERGAYQTFQGSLWSQGI 722 Query: 578 LPIDTYKKDLDTIANEPLH------YDWEALRESIKTHGLRNSTLSALMPSETSSQISNA 631 LPID+ KK ++ + + DW LRE ++ G+RNS + A+ P+ T + I+ Sbjct: 723 LPIDSEKKLIEERGAKYIEVDLSETLDWAPLRERVQ-KGIRNSNIMAIAPTATIANITGV 781 Query: 632 TNGIEPPRGYVSIKASKDGILRQVVP 657 + IEP + +K++ G + P Sbjct: 782 SQSIEPTYQNLYVKSNLSGEFTVINP 807 >5D1Y-A nrPDB Length = 812 Score = 243 bits (621), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 216/784 (27%), Positives = 343/784 (43%), Gaps = 85/784 (10%) Query: 7 VTKRDGSTERINLDKIHRVLDWAAEGLHN--VSISQVELRSHIQFYDGIKTSDIHETIIK 64 V KRDG ER+ DKI + GL+ V +Q+ ++ Y G+ T ++ + Sbjct: 23 VIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAE 82 Query: 65 AAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPA--LYDHVVKMVEMGKYDNHLLE- 121 AA L ++ PDY LAAR+A+ +L K+ F LY+++ GK+ + + Sbjct: 83 TAATLTTKH-PDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINP--HNGKHSPMVAKS 139 Query: 122 --DYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAAC 179 D ++++ I +DRD +++Y K LE YL+ ++ G++ E Q + + V+ Sbjct: 140 TLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLL--KINGKVAERPQHMLMRVSVG 197 Query: 180 LFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGD-SLDSIN 238 + + + Y+ +S + +P + T Q SSC L+ D S++ I Sbjct: 198 I-----HKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIY 252 Query: 239 ATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGG-V 297 T GIG+ IRA GS I G G +P + + + QGG Sbjct: 253 DTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNK 312 Query: 298 RGGAATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFS 357 R GA ++ WHL++ L LK N G E R R + + + I L R+ +D +L Sbjct: 313 RPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMC 372 Query: 358 PSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNV 417 P++ PGL + + EEFE+LY YEK +RK VKA +L+ +++ + TG Y+ Sbjct: 373 PNECPGLDEVW---GEEFEKLYASYEKQGRVRKV-VKAQQLWYAIIESQTETGTPYMLYK 428 Query: 418 DHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGA------ 471 D CN S + ++ SNLC EI T E+A+C L++ L Sbjct: 429 DSCNRKSN-QQNLGTIKCSNLCTEIVEYT--------SKDEVAVCNLASLALNMYVTSEH 479 Query: 472 INNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRY 531 + +L E+ + VR L+ ++D YP+P A R +GIGV A + Sbjct: 480 TYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPF 539 Query: 532 SDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIA 591 A L + FE I Y L+AS +LAKEQG + + +KGIL D + + Sbjct: 540 ESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDL- 598 Query: 592 NEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGI 651 +DW+ L+E I +G+RNS L A MP+ +++QI IEP + + G Sbjct: 599 -----WDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGE 653 Query: 652 LRQVVPDY--------------------------------EHLHDAYELLWEMPGNDGYL 679 + V P + L Y+ +WE+ L Sbjct: 654 FQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEI-SQKTVL 712 Query: 680 QLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLTAYKFGVKT-LYYQNTRDGA 738 ++ FIDQS S N + + GK+ +K G+KT +YY TR A Sbjct: 713 KMAAERGAFIDQSQSLNIHIAEPNY--GKLTSMHFY-----GWKQGLKTGMYYLRTRPAA 765 Query: 739 EDAQ 742 Q Sbjct: 766 NPIQ 769 >2ZLF-A nrPDB Length = 888 Score = 241 bits (616), Expect = 7e-64, Method: Compositional matrix adjust. Identities = 223/808 (27%), Positives = 353/808 (43%), Gaps = 93/808 (11%) Query: 5 LLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHI--QFYDGIKTSDIHETI 62 + V KRDG E + DKI + GL I V++ I Y+G+ T ++ Sbjct: 1 MYVYKRDGRKEPVQFDKITARISRLCYGLDPKHIDAVKVTQRIISGVYEGVTTIELDNLA 60 Query: 63 IKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPA--LYDHVVKMVEMGKYDNHLL 120 + A + + PDY LAAR+AI +L K+ QF LY +V GK + Sbjct: 61 AETCAYMTTVH-PDYATLAARIAISNLHKQTTKQFSKVVEDLYRYV--NAATGKPAPMIS 117 Query: 121 EDY---TEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVA 177 +D E ++++ I +DRD +SY K LE YL+ R+ G++ E Q L + VA Sbjct: 118 DDVYNIVMENKDKLNSAIVYDRDFQYSYFGFKTLERSYLL--RINGQVAERPQHLIMRVA 175 Query: 178 ACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECG-DSLDS 236 + ++ Y+ +S + +P + TP Q SSC L+ DS++ Sbjct: 176 LGIHGR-----DIEAALETYNLMSLKYFTHASPTLFNAGTPKPQMSSCFLVAMKEDSIEG 230 Query: 237 INATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGG 296 I T GIG++ IR+ GS I G G IP + F + QGG Sbjct: 231 IYDTLKECALISKTAGGIGLHIHNIRSTGSYIAGTNGTSNGLIPMIRVFNNTARYVDQGG 290 Query: 297 -VRGGAATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITL 355 R GA L+ WH ++ + ++ N G E R R + + I L R+ + TL Sbjct: 291 NKRPGAFALYLEPWHADIFDFIDIRKNHGKEEIRARDLFPALWIPDLFMKRVEENGTWTL 350 Query: 356 FSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQ 415 FSP+ PGL D + +EFE LYT+YEK+ R + +KA +L+ +++ + TG ++ Sbjct: 351 FSPTSAPGLSDCY---GDEFEALYTRYEKEG--RGKTIKAQKLWYSILEAQTETGTPFVV 405 Query: 416 NVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAI--- 472 D CN S + ++ SNLC EI + P E A+C L++ L A Sbjct: 406 YKDACNRKSN-QKNLGVIKSSNLCCEIVEYSAP--------DETAVCNLASVALPAFIET 456 Query: 473 --------NNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYL 524 N +L E+A + R L+ ++D YP+ A++ M R + +GV A Sbjct: 457 SEDGKTSTYNFKKLHEIAKVVTRNLNRVIDRNYYPVEEARKSNMRHRPIALGVQGLADTF 516 Query: 525 AKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYK 584 + A L + FE I + ++AS ELA++ G F + ++GIL D + Sbjct: 517 MLLRLPFDSEEARLLNIQIFETIYHASMEASCELAQKDGPYETFQGSPASQGILQFDMWD 576 Query: 585 KDLDTIANEPL-HYDWEALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPP----- 638 + +P +DW+ LR+ I HG+RNS A MP+ ++SQI EP Sbjct: 577 Q-------KPYGMWDWDTLRKDIMKHGVRNSLTMAPMPTASTSQILGYNECFEPVTSNMY 629 Query: 639 -----------------RGYVSIKASKDGILR---------QVVPDY-EHLHDAYELLWE 671 R V + +G+ + Q +P+ + L D Y+ +WE Sbjct: 630 SRRVLSGEFQVVNPYLLRDLVDLGIWDEGMKQYLITQNGSIQGLPNVPQELKDLYKTVWE 689 Query: 672 MPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLTAYKFGVKT-LY 730 + + + +IDQS S N R P+ M +L +K G+KT +Y Sbjct: 690 I-SQKTIINMAADRSVYIDQSHSLNLFL---RAPT----MGKLTSMHFYGWKKGLKTGMY 741 Query: 731 YQNTRDGAEDAQDDLVPSIQDDGCESGA 758 Y T+ + Q + I D E+ A Sbjct: 742 YLRTQAASAAIQFTIDQKIADQATENVA 769 >2WGH-A nrPDB Length = 676 Score = 219 bits (558), Expect = 3e-57, Method: Compositional matrix adjust. Identities = 191/702 (27%), Positives = 305/702 (43%), Gaps = 82/702 (11%) Query: 80 LAARLAIFHLRKKAYGQFEPPA--LYDHVVKMVEMGKYDNHLLE---DYTEEEFKQMDTF 134 LAAR+A+ +L K+ F LY+++ GK+ + + D ++++ Sbjct: 4 LAARIAVSNLHKETKKVFSDVMEDLYNYINP--HNGKHSPMVAKSTLDIVLANKDRLNSA 61 Query: 135 IDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLQYVK 194 I +DRD +++Y K LE YL+ ++ G++ E Q + + V+ + + + Sbjct: 62 IIYDRDFSYNYFGFKTLERSYLL--KINGKVAERPQHMLMRVSVGI-----HKEDIDAAI 114 Query: 195 RFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGD-SLDSINATSSAIVKYVSQRAG 253 Y+ +S + +P + T Q SSC L+ D S++ I T G Sbjct: 115 ETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGG 174 Query: 254 IGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGG-VRGGAATLFYPMWHLE 312 IG+ IRA GS I G G +P + + + QGG R GA ++ WHL+ Sbjct: 175 IGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLD 234 Query: 313 VESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFADQ 372 + L LK N G E R R + + + I L R+ +D +L P++ PGL + + Sbjct: 235 IFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVW---G 291 Query: 373 EEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPAIAP 432 EEFE+LY YEK +RK VKA +L+ +++ + TG Y+ D CN S + Sbjct: 292 EEFEKLYASYEKQGRVRKV-VKAQQLWYAIIESQTETGTPYMLYKDSCNRKSN-QQNLGT 349 Query: 433 VRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGA------INNLDELEELAILAV 486 ++ SNLC EI T E+A+C L++ L + +L E+ + V Sbjct: 350 IKCSNLCTEIVEYT--------SKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVV 401 Query: 487 RALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEA 546 R L+ ++D YP+P A R +GIGV A + A L + FE Sbjct: 402 RNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFET 461 Query: 547 IQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESI 606 I Y L+AS +LAKEQG + + +KGIL D + + +DW+ L+E I Sbjct: 462 IYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDL------WDWKVLKEKI 515 Query: 607 KTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDY------- 659 +G+RNS L A MP+ +++QI IEP + + G + V P Sbjct: 516 AKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTER 575 Query: 660 -------------------------EHLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSIS 694 + L Y+ +WE+ L++ FIDQS S Sbjct: 576 GLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEI-SQKTVLKMAAERGAFIDQSQS 634 Query: 695 ANTNYDPSRFPSGKVPMQQLLKDLLTAYKFGVKT-LYYQNTR 735 N + + GK+ +K G+KT +YY TR Sbjct: 635 LNIHIAEPNY--GKLTSMHFY-----GWKQGLKTGMYYLRTR 669 >6CGM-A nrPDB Length = 700 Score = 151 bits (381), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 155/663 (23%), Positives = 295/663 (44%), Gaps = 62/663 (9%) Query: 117 NHLLED-YTEEEFKQMDTFID--------HDRDMTF-SYAAVKQLEGKYLVQNRVTGEIY 166 ++L+E+ Y EEEF + +F D + + F S+ + + Y ++ +I Sbjct: 56 DYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYNDYALKTNDKKKIL 115 Query: 167 ESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCV 226 E + I + A F+N E +YV + ++ S PT + +G R + SC Sbjct: 116 ERYE-DRISIVALFFANGDTEKAKEYVNLMIN--QEYQPSTPTFLNAG-RKRRGELVSCF 171 Query: 227 LIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQ 286 L+E DSL+ I+ ++ G+ +N ++RA G I+ E G + K Sbjct: 172 LLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVENATKGVVGVMKLLD 231 Query: 287 TAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTR 346 A + Q G R G+ + ++H ++ L K E RV+ + GV I Sbjct: 232 NAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVKTLSIGVVIPDKFVEL 291 Query: 347 LLKGEDITLFSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQER 406 + + +F P + Y D+ + +Y K+ + ++K+++ +L + R Sbjct: 292 AREDKAAYVFYPHTIYKEYGQHM-DEMDMNEMYDKFVDNPRVKKEKINPRKLLEKLAMLR 350 Query: 407 ASTGRIYIQ---NVD--HCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVN-DENGEIA 460 + +G YI NV+ H N H I+ V+ SNLC E+ ++ + + DE EI Sbjct: 351 SESGYPYIMFQDNVNKVHANNH------ISKVKFSNLCSEVLQASQVSSYTDYDEEDEIG 404 Query: 461 L---CTLSAFNLGAINNLDELEELAILAVRALDALLDYQDY-PIPAAKRGAMGRRTLGIG 516 L C L + N+ + +E+ LA +L + + D PA +R +++G+G Sbjct: 405 LDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPAVRRANKAMKSIGLG 464 Query: 517 VINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGAC-PWFNETTYAK 575 +N YLA++G Y A + + F + +Y ++ S E+AKE+G + +TYA Sbjct: 465 AMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAKEKGETFDQYEGSTYAT 524 Query: 576 G-----ILPIDTYKKDLDTIAN--EPLHY----DWEALRESIKTHGLRNSTLSALMPSET 624 G + D + + IAN E +H DW+ L+ + HG+ +S + P+ + Sbjct: 525 GEYFDKYVSTD-FSPKYEKIANLFEGMHIPTTEDWKKLKAFVAEHGMYHSYRLCIAPTGS 583 Query: 625 SSQISNATNGIEPPRGYVSIKASKDGILRQVVP-----DYEHLHDAYEL-LWEMPGNDGY 678 S + ++T + P + + + +P ++ +AY++ ++++ Sbjct: 584 ISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWFFYKEAYDMDMFKV------ 637 Query: 679 LQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLTAYKFGVKTLYYQNTRDGA 738 + ++ +Q+ IDQ IS + F + + L + L A+ G+KT+YY T+D Sbjct: 638 VDMIATIQQHIDQGISF------TLFLKDTMTTRDLNRIDLYAHHRGIKTIYYARTKDTG 691 Query: 739 EDA 741 +D+ Sbjct: 692 QDS 694 >1PEQ-A nrPDB Length = 714 Score = 142 bits (358), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 141/581 (24%), Positives = 241/581 (41%), Gaps = 49/581 (8%) Query: 203 FKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIR 262 F+ + PT + G + + SC L+ D+++SI ++ ++ + G+ +R Sbjct: 157 FQPATPTFLNCG-KQQRGELVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLR 215 Query: 263 ALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNN 322 G+PI+ E +G IP K + A +Q G R GA ++ H ++ L K Sbjct: 216 EAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGAGAVYLHAHHPDILRFLDTKRE 275 Query: 323 RGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFADQEEFERLYTKY 382 E R++ + GV I + + + + LFSP D+ Y F D ER Y + Sbjct: 276 NADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPYDIQRRYGKPFGDIAISER-YDEL 334 Query: 383 EKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEI 442 D +RK + A + F + + + +G YI D N +P + SNLC EI Sbjct: 335 IADPHVRKTYINARDFFQTLAEIQFESGYPYIMFEDTVNRANPI---AGRINMSNLCSEI 391 Query: 443 ALPTKPLNDVND-----ENGEIALCTLSAFNLGAINNLDELEELAILAVRALDALLDYQD 497 L + +D G C L + N+ + + ++ A+R L A+ D Sbjct: 392 -LQVNSASRYDDNLDYTHIGHDISCNLGSLNIAHVMDSPDIGRTVETAIRGLTAVSDMSH 450 Query: 498 Y-PIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASN 556 +P+ G +G+G +N YLA+ G Y A + T+ F I ++ + S Sbjct: 451 IRSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALDFTNLYFYTITWHAVHTSM 510 Query: 557 ELAKEQGAC-PWFNETTYAKG-----ILPIDTYKKDLDTIA-------NEPLHYDWEALR 603 LA+E+G F ++ YA G L D K A P W LR Sbjct: 511 RLARERGKTFAGFAQSRYASGDYFTQYLQDDWQPKTAKVRALFARSGITLPTREMWLKLR 570 Query: 604 ESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSI-KASKDGILRQVVP----- 657 + + +G+ N L A+ P+ + S I++AT+ I P + I K K G + P Sbjct: 571 DDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKEGKTGRVYYPAPFMTNE 630 Query: 658 DYEHLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKD 717 + + DAY++ G + + + +DQ +S + F + + K Sbjct: 631 NLDMYQDAYDI-----GPEKIIDTYAEATRHVDQGLSL------TLFFPDTATTRDINKA 679 Query: 718 LLTAYKFGVKTLYYQNTRDGAEDAQDDLVPSIQDDGCESGA 758 + A++ G+K+LYY R A + + +GC S A Sbjct: 680 QIYAWRKGIKSLYYIRLRQLA-------LEGTEIEGCVSCA 713 >6DQW-A nrPDB Length = 585 Score = 107 bits (266), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 141/606 (23%), Positives = 237/606 (39%), Gaps = 152/606 (25%) Query: 196 FYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQRAGIG 255 F + + +S+ +P+ + + T SC + D ++ I ++ G Sbjct: 87 FVEMIERGWMSISSPVWANMGTERGLPISCFNVHVPDKIEGITHKLGEVIMQTKIGGGTS 146 Query: 256 INAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVES 315 G +R GS + +G + F K F TA+ + SQGGVR GA + + H ++E Sbjct: 147 GYFGELRERGSAVTD-NGKSSGAVSFMKLFDTAMDTISQGGVRRGAFAAYLDIDHPDIEE 205 Query: 316 LLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFADQEEF 375 L +K+ GN ++++ G+ + ++ G+ AD+ + Sbjct: 206 FLKIKSI----GNPIQNLFTGICVPDYWMQEMIDGD------------------ADKRQ- 242 Query: 376 ERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSP--FDPAIAPV 433 +++ +++ R G YI D+ N + P + + Sbjct: 243 ----------------------IWAKVLESRQQKGLPYIFFSDNVNKNKPQVYKDQNLRI 280 Query: 434 RQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAINNLDELEELAILAVRALDALL 493 SNLC EI LP+ +DE+ +C LS+ NL + E + LA+ LDA+L Sbjct: 281 NASNLCSEIMLPS-----THDES---FICCLSSMNLELYEEWKDTEAVK-LAIFFLDAVL 331 Query: 494 DY------QDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAI 547 +Y + AA + A R LG+GV+ + YL K+ + A T + F+ I Sbjct: 332 QEFIEKTEGNYYLSAANKFAKRHRALGLGVLGWHSYLQKNMIPFEGMEAKMKTTEIFKHI 391 Query: 548 QYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIK 607 KAS ELA+ I EP E +K Sbjct: 392 SDKADKASQELAR-----------------------------IYGEP---------ELLK 413 Query: 608 THGLRNSTLSALMPSETSSQISNATN-GIEP-PRGYVSIKASKDGILRQVV--------- 656 +G RN+T A+ P+ +SS I T+ GIEP Y SK +R+ Sbjct: 414 GYGRRNTTTMAIAPTTSSSAILGQTSPGIEPFSSNYYKAGLSKGNFMRKNKYLKKLLEEK 473 Query: 657 ---------------PDYEHL-------HDAYELLWEMPGNDGYLQLVGIMQKFIDQSIS 694 +H+ D ++ E+ + +Q GI QKF+DQ S Sbjct: 474 GLDNEEVWRGIMLNGGSVQHMSQLTQQEKDVFKTFKEISQLE-IVQQAGIRQKFVDQGQS 532 Query: 695 ANTNYDPSRFPSGKVPMQQLLKD----LLTAYKFGVKTLYYQNTRDGAEDAQDDLVPSIQ 750 N N +P + +KD ++ A++ GVK+LYYQ ++ +++ LV Sbjct: 533 LNLN----------IPAELAIKDVNRLMIEAWQQGVKSLYYQRSQSVSKELVTSLVSC-- 580 Query: 751 DDGCES 756 CES Sbjct: 581 -SSCES 585 >6DQX-A nrPDB Length = 574 Score = 100 bits (248), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 142/604 (23%), Positives = 225/604 (37%), Gaps = 143/604 (23%) Query: 192 YVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQR 251 Y +FY ++ SL +PI S SC GDS+ I T++ + Sbjct: 72 YADKFYHYMARGYFSLSSPIWSNFGLDRGLPISCFGSYIGDSIHEIMVTTAEVGMMSKIG 131 Query: 252 AGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHL 311 G G IR GS I+ G F K F T + SQG R G + + H Sbjct: 132 GGTSAYFGDIRPRGSAIKNNGK-SDGSFNFSKLFDTVIDVISQGTSRKGQFAGYIDIEHG 190 Query: 312 EVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFAD 371 +++ L + EGN ++ M YGV + + G Sbjct: 191 DIDEWLDIH----TEGNPIQLMYYGVCVGHDWLESMKAG--------------------- 225 Query: 372 QEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSP--FDPA 429 D ++Q L++ ++Q + TG Y+ D+ N P + Sbjct: 226 --------------DPYKRQ------LWAKLLQRKTETGIPYLFFKDNANAGRPDVYKDK 265 Query: 430 IAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAINNLDELEELAILAVRAL 489 V SNLC EI LP+ N E +C LS+ NL + + E +L L Sbjct: 266 NMTVHASNLCTEIMLPSS--------NDESFVCCLSSMNLLYFDEWKDTEAPEVLTY-FL 316 Query: 490 DALLD-----YQDYP-IPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKT 543 D ++ +D P + A R A R LG+GV+ + YL + + A + Sbjct: 317 DVVMSEFIEKSKDMPFLDRAHRFATRHRALGLGVLGWHSYLQANNIAFDSFQAMQKNNLI 376 Query: 544 FEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALR 603 F+ +Q LKAS ELAK G EP Sbjct: 377 FKTLQEKTLKASQELAKRFG-----------------------------EP--------- 398 Query: 604 ESIKTHGLRNSTLSALMPSETSSQI-SNATNGIEPPRGYVSIK-------ASKDGILRQV 655 E +K +G RN+TL ++ P+++SS I + + +EP + +K K+ L ++ Sbjct: 399 EILKGYGRRNTTLMSIAPTKSSSFILGSVSPSVEPFKSNYYVKDLAKIKTVYKNPFLEKL 458 Query: 656 VPDYEHLHDAYELLWEMPGNDGYLQLVGIM--------------------------QKFI 689 + E D E+ + NDG +Q + + QK+I Sbjct: 459 LQ--EKGLDTEEIWESILHNDGSVQHLEQLTDEEKEVFKTFSEISQLSVIQQAAQRQKYI 516 Query: 690 DQSISANTNYDPSRFPSGKVPMQQLLKDLLTAYKFGVKTLYYQNTRDGAEDAQDDLVPSI 749 DQ S N P+ P + L + LTA + G+K++YYQ + A+ +L+ Sbjct: 517 DQGQSINIMVHPA------TPARDLNQLYLTAEELGLKSIYYQYSMSAAQVFNRNLLSCS 570 Query: 750 QDDG 753 +G Sbjct: 571 SCEG 574 >3O0O-A nrPDB Length = 644 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 109/439 (24%), Positives = 177/439 (40%), Gaps = 74/439 (16%) Query: 216 RTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFH 275 R S+C ++ GDS++ I G+G N +R GS + G Sbjct: 125 RNHLHMLSACFVVPVGDSIEEIFEAVKEYALITKVGGGVGSNFSELRPKGSFVAGTHGKA 184 Query: 276 TGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLL-VLKNNRGVEGNRVRHMD 334 +G + F F +A+ QG R GA + H ++E + K N G ++ Sbjct: 185 SGPVSFMHVFNSAISVVKQGSRRRGALMGILNINHPDIEEFIDAKKENTGEAVLNFFNLS 244 Query: 335 YGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVK 394 G ++K ++ LY+ + E E + + +IRK +VK Sbjct: 245 VGFPMDK-----------------KEILKLYE----EDGELELSHPR----STIRK-KVK 278 Query: 395 AVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVND 454 ELF + +G DP +A + + N P P +N Sbjct: 279 IRELFRKIATNAWKSG----------------DPGLAFLGEMNKY----YPLYPHRKINS 318 Query: 455 EN--GEIALCTLSAFNLGAIN----------NLDELEELAILAVRALDALLDYQDYPIPA 502 N GEI L A NLG+I+ +L+ L+EL +AVR LD ++D +PI Sbjct: 319 TNPCGEIGLSDYEACNLGSIDVAKFYNNGFVDLEALQELVQIAVRFLDNVIDVNVFPIDK 378 Query: 503 AKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQ 562 + R LG+G++ FA L K Y+ A + I + + S EL KE+ Sbjct: 379 ITKAVKESRRLGLGIMGFADLLYKLEIPYNSQEARDFAANLMAFIALHAHRTSYELGKEK 438 Query: 563 GACPWFNETTYAKGILPIDTYKKDLDTI--ANEPLHYDWEALRESIKT--HGLRNSTLSA 618 G P +L I Y+ + + + A +YD E +RE +K RN L Sbjct: 439 GNFP----------LLEISRYRTEDNFVPFAMGMSNYDDE-IREVMKMTKEFRRNVALLT 487 Query: 619 LMPSETSSQISNATNGIEP 637 + P+ + S I++ ++G+EP Sbjct: 488 IAPTGSISNIADTSSGLEP 506 >3SDU-A nrPDB Length = 817 Score = 35.0 bits (79), Expect = 0.14, Method: Compositional matrix adjust. Identities = 27/103 (26%), Positives = 47/103 (45%), Gaps = 3/103 (2%) Query: 108 KMVEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYE 167 K +E+GK D ++++ +EE K + ++ F++A + LE +LV Y Sbjct: 490 KFLELGKLDFNIIQSIHQEEMKNVTSWFRDSGLPLFTFARERPLEFYFLVAAGTYEPQYA 549 Query: 168 SAQFLYILVAA---CLFSNYPRETRLQYVKRFYDAVSTFKISL 207 +FL+ VA L Y L +K F +AV + +S Sbjct: 550 KCRFLFTKVACLQTVLDDMYDTYGTLDELKLFTEAVRRWDLSF 592 >4HSC-X nrPDB Length = 571 Score = 32.0 bits (71), Expect = 1.0, Method: Compositional matrix adjust. Identities = 23/105 (21%), Positives = 44/105 (41%), Gaps = 9/105 (8%) Query: 516 GVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLL--------KASNELAKEQGACPW 567 GV N Y+ Y+ G N L+H+ QY +L K + K + W Sbjct: 445 GVNNRTEYVETTSTEYTSGKIN-LSHQGAYVAQYEILWDEINYDDKGKEVITKRRWDNNW 503 Query: 568 FNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLR 612 +++T+ ++P+ +++ +A E WE R+ I ++ Sbjct: 504 YSKTSPFSTVIPLGANSRNIRIMARECTGLAWEWWRKVIDERDVK 548 >6O9P-A nrPDB Length = 566 Score = 30.8 bits (68), Expect = 2.1, Method: Compositional matrix adjust. Identities = 36/126 (28%), Positives = 56/126 (44%), Gaps = 14/126 (11%) Query: 41 VELRSHIQFYDGIKTSDIH---ETIIKAAADLISRDAPDYQY---LAARLAIFHLRKKAY 94 +E + ++F D ++ + ET +K A IS+D D + L A F L ++ Sbjct: 74 MEPLAKLEFIDSVRRLGLKYQFETEMKEALANISKDGYDSWWVDNLRATALRFRLLREN- 132 Query: 95 GQFEPPALYDHVVKMVEMGKYDNHLLEDYT------EEEFKQMDTFIDHDRDMTFSYAAV 148 G F P +++ + E GK+ N L ED E F + D TFS A + Sbjct: 133 GIFVPQDVFERF-QNKETGKFKNELCEDVKGLLNLYEASFLGWEGEDILDEARTFSTAQL 191 Query: 149 KQLEGK 154 K +EGK Sbjct: 192 KNVEGK 197 >4FE1-B nrPDB Length = 740 Score = 30.4 bits (67), Expect = 3.2, Method: Compositional matrix adjust. Identities = 16/50 (32%), Positives = 26/50 (52%), Gaps = 5/50 (10%) Query: 155 YLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFK 204 Y + R G++Y+ A FL IL + LF+ + L +F ++S FK Sbjct: 124 YTIGMRTNGDLYQGAIFLLILASLALFAGW-----LHLQPKFRPSLSWFK 168 >3R42-A nrPDB Length = 162 Score = 28.9 bits (63), Expect = 9.8, Method: Composition-based stats. Identities = 17/60 (28%), Positives = 28/60 (46%) Query: 425 PFDPAIAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAINNLDELEELAIL 484 P P + N + + P+ + D NG IAL L A++ A+N + ++EL L Sbjct: 94 PVKPPFISINLENFDMNTISSSLPIQEYIDSNGWIALPILHAWDPAAMNLIMVVQELMSL 153 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5R1R-A nrPDB 1047 0.0 5D1Y-A nrPDB 866 0.0 2ZLF-A nrPDB 849 0.0 2WGH-A nrPDB 776 0.0 5IM3-A nrPDB 770 0.0 6CGM-A nrPDB 618 e-177 1PEQ-A nrPDB 604 e-173 6DQW-A nrPDB 477 e-135 6DQX-A nrPDB 474 e-134 3O0O-A nrPDB 368 e-102 Sequences not found previously or not previously below threshold: 1L1L-A nrPDB 42 8e-04 3OHM-B nrPDB 38 0.024 4QJ3-B nrPDB 34 0.20 1XI9-A nrPDB 33 0.58 5BRL-A nrPDB 31 1.4 >5R1R-A nrPDB Length = 761 Score = 1047 bits (2708), Expect = 0.0, Method: Composition-based stats. Identities = 760/761 (99%), Positives = 760/761 (99%) Query: 1 MNQNLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGIKTSDIHE 60 MNQNLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGIKTSDIHE Sbjct: 1 MNQNLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGIKTSDIHE 60 Query: 61 TIIKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDNHLL 120 TIIKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDNHLL Sbjct: 61 TIIKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDNHLL 120 Query: 121 EDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACL 180 EDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACL Sbjct: 121 EDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACL 180 Query: 181 FSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINAT 240 FSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINAT Sbjct: 181 FSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINAT 240 Query: 241 SSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGG 300 SSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGG Sbjct: 241 SSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGG 300 Query: 301 AATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSD 360 AATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSD Sbjct: 301 AATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSD 360 Query: 361 VPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHC 420 VPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHC Sbjct: 361 VPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHC 420 Query: 421 NTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAINNLDELEE 480 NTHSPFDPAIAPVRQSNLCL IALPTKPLNDVNDENGEIALCTLSAFNLGAINNLDELEE Sbjct: 421 NTHSPFDPAIAPVRQSNLCLAIALPTKPLNDVNDENGEIALCTLSAFNLGAINNLDELEE 480 Query: 481 LAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLT 540 LAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLT Sbjct: 481 LAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLT 540 Query: 541 HKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWE 600 HKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWE Sbjct: 541 HKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWE 600 Query: 601 ALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDYE 660 ALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDYE Sbjct: 601 ALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDYE 660 Query: 661 HLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLT 720 HLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLT Sbjct: 661 HLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLT 720 Query: 721 AYKFGVKTLYYQNTRDGAEDAQDDLVPSIQDDGCESGACKI 761 AYKFGVKTLYYQNTRDGAEDAQDDLVPSIQDDGCESGACKI Sbjct: 721 AYKFGVKTLYYQNTRDGAEDAQDDLVPSIQDDGCESGACKI 761 >5D1Y-A nrPDB Length = 812 Score = 866 bits (2238), Expect = 0.0, Method: Composition-based stats. Identities = 216/789 (27%), Positives = 344/789 (43%), Gaps = 85/789 (10%) Query: 5 LLVTKRDGSTERINLDKIHRVLDWAAEGLHN--VSISQVELRSHIQFYDGIKTSDIHETI 62 + V KRDG ER+ DKI + GL+ V +Q+ ++ Y G+ T ++ Sbjct: 21 MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLA 80 Query: 63 IKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPA--LYDHVVKMVEMGKYDNHLL 120 + AA L ++ PDY LAAR+A+ +L K+ F LY+++ GK+ + Sbjct: 81 AETAATLTTKH-PDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINP--HNGKHSPMVA 137 Query: 121 E---DYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVA 177 + D ++++ I +DRD +++Y K LE YL+ ++ G++ E Q + + V+ Sbjct: 138 KSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLL--KINGKVAERPQHMLMRVS 195 Query: 178 ACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGD-SLDS 236 + + + Y+ +S + +P + T Q SSC L+ D S++ Sbjct: 196 VGI-----HKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEG 250 Query: 237 INATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGG 296 I T GIG+ IRA GS I G G +P + + + QGG Sbjct: 251 IYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGG 310 Query: 297 -VRGGAATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITL 355 R GA ++ WHL++ L LK N G E R R + + + I L R+ +D +L Sbjct: 311 NKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSL 370 Query: 356 FSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQ 415 P++ PGL + + EEFE+LY YEK +RK VKA +L+ +++ + TG Y+ Sbjct: 371 MCPNECPGLDEVW---GEEFEKLYASYEKQGRVRKV-VKAQQLWYAIIESQTETGTPYML 426 Query: 416 NVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAI--- 472 D CN S + ++ SNLC EI T E+A+C L++ L Sbjct: 427 YKDSCNRKSN-QQNLGTIKCSNLCTEIVEYT--------SKDEVAVCNLASLALNMYVTS 477 Query: 473 ---NNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGK 529 + +L E+ + VR L+ ++D YP+P A R +GIGV A Sbjct: 478 EHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRY 537 Query: 530 RYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDT 589 + A L + FE I Y L+AS +LAKEQG + + +KGIL D + Sbjct: 538 PFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTD 597 Query: 590 IANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKD 649 + +DW+ L+E I +G+RNS L A MP+ +++QI IEP + + Sbjct: 598 L------WDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLS 651 Query: 650 GILRQVVPDY--------------------------------EHLHDAYELLWEMPGNDG 677 G + V P + L Y+ +WE+ Sbjct: 652 GEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEI-SQKT 710 Query: 678 YLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLTAYKFGVKT-LYYQNTRD 736 L++ FIDQS S N + + +L +K G+KT +YY TR Sbjct: 711 VLKMAAERGAFIDQSQSLNIHIAEPNY-------GKLTSMHFYGWKQGLKTGMYYLRTRP 763 Query: 737 GAEDAQDDL 745 A Q L Sbjct: 764 AANPIQFTL 772 >2ZLF-A nrPDB Length = 888 Score = 849 bits (2193), Expect = 0.0, Method: Composition-based stats. Identities = 218/807 (27%), Positives = 343/807 (42%), Gaps = 91/807 (11%) Query: 5 LLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHI--QFYDGIKTSDIHETI 62 + V KRDG E + DKI + GL I V++ I Y+G+ T ++ Sbjct: 1 MYVYKRDGRKEPVQFDKITARISRLCYGLDPKHIDAVKVTQRIISGVYEGVTTIELDNLA 60 Query: 63 IKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPA--LYDHVVKMVEMGKYDNHLL 120 + A + + PDY LAAR+AI +L K+ QF LY +V GK + Sbjct: 61 AETCAYMTTVH-PDYATLAARIAISNLHKQTTKQFSKVVEDLYRYVN--AATGKPAPMIS 117 Query: 121 EDYT---EEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVA 177 +D E ++++ I +DRD +SY K LE YL+ R+ G++ E Q L + VA Sbjct: 118 DDVYNIVMENKDKLNSAIVYDRDFQYSYFGFKTLERSYLL--RINGQVAERPQHLIMRVA 175 Query: 178 ACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECG-DSLDS 236 + ++ Y+ +S + +P + TP Q SSC L+ DS++ Sbjct: 176 LGIHGR-----DIEAALETYNLMSLKYFTHASPTLFNAGTPKPQMSSCFLVAMKEDSIEG 230 Query: 237 INATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGG 296 I T GIG++ IR+ GS I G G IP + F + QGG Sbjct: 231 IYDTLKECALISKTAGGIGLHIHNIRSTGSYIAGTNGTSNGLIPMIRVFNNTARYVDQGG 290 Query: 297 -VRGGAATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITL 355 R GA L+ WH ++ + ++ N G E R R + + I L R+ + TL Sbjct: 291 NKRPGAFALYLEPWHADIFDFIDIRKNHGKEEIRARDLFPALWIPDLFMKRVEENGTWTL 350 Query: 356 FSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQ 415 FSP+ PGL D + +EFE LYT+YEK+ R + +KA +L+ +++ + TG ++ Sbjct: 351 FSPTSAPGLSDCY---GDEFEALYTRYEKEG--RGKTIKAQKLWYSILEAQTETGTPFVV 405 Query: 416 NVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAI--- 472 D CN S + ++ SNLC EI + P E A+C L++ L A Sbjct: 406 YKDACNRKSN-QKNLGVIKSSNLCCEIVEYSAP--------DETAVCNLASVALPAFIET 456 Query: 473 --------NNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYL 524 N +L E+A + R L+ ++D YP+ A++ M R + +GV A Sbjct: 457 SEDGKTSTYNFKKLHEIAKVVTRNLNRVIDRNYYPVEEARKSNMRHRPIALGVQGLADTF 516 Query: 525 AKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYK 584 + A L + FE I + ++AS ELA++ G F + ++GIL D + Sbjct: 517 MLLRLPFDSEEARLLNIQIFETIYHASMEASCELAQKDGPYETFQGSPASQGILQFDMWD 576 Query: 585 KDLDTIANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSI 644 + +DW+ LR+ I HG+RNS A MP+ ++SQI EP + Sbjct: 577 QKP------YGMWDWDTLRKDIMKHGVRNSLTMAPMPTASTSQILGYNECFEPVTSNMYS 630 Query: 645 KASKDGILRQVVPDY--------------------------------EHLHDAYELLWEM 672 + G + V P + L D Y+ +WE+ Sbjct: 631 RRVLSGEFQVVNPYLLRDLVDLGIWDEGMKQYLITQNGSIQGLPNVPQELKDLYKTVWEI 690 Query: 673 PGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLTAYKFGVKT-LYY 731 + + +IDQS S N M +L +K G+KT +YY Sbjct: 691 -SQKTIINMAADRSVYIDQSHSLNLFLRAP-------TMGKLTSMHFYGWKKGLKTGMYY 742 Query: 732 QNTRDGAEDAQDDLVPSIQDDGCESGA 758 T+ + Q + I D E+ A Sbjct: 743 LRTQAASAAIQFTIDQKIADQATENVA 769 >2WGH-A nrPDB Length = 676 Score = 776 bits (2003), Expect = 0.0, Method: Composition-based stats. Identities = 190/705 (26%), Positives = 304/705 (43%), Gaps = 82/705 (11%) Query: 78 QYLAARLAIFHLRKKAYGQFEPPA--LYDHVVKMVEMGKYDNHLLE---DYTEEEFKQMD 132 LAAR+A+ +L K+ F LY+++ GK+ + + D +++ Sbjct: 2 AILAARIAVSNLHKETKKVFSDVMEDLYNYINP--HNGKHSPMVAKSTLDIVLANKDRLN 59 Query: 133 TFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLQY 192 + I +DRD +++Y K LE YL+ ++ G++ E Q + + V+ + + + Sbjct: 60 SAIIYDRDFSYNYFGFKTLERSYLL--KINGKVAERPQHMLMRVSVGI-----HKEDIDA 112 Query: 193 VKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGD-SLDSINATSSAIVKYVSQR 251 Y+ +S + +P + T Q SSC L+ D S++ I T Sbjct: 113 AIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSA 172 Query: 252 AGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGG-VRGGAATLFYPMWH 310 GIG+ IRA GS I G G +P + + + QGG R GA ++ WH Sbjct: 173 GGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWH 232 Query: 311 LEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFA 370 L++ L LK N G E R R + + + I L R+ +D +L P++ PGL + + Sbjct: 233 LDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVW-- 290 Query: 371 DQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPAI 430 EEFE+LY YEK +RK VKA +L+ +++ + TG Y+ D CN S + Sbjct: 291 -GEEFEKLYASYEKQGRVRKV-VKAQQLWYAIIESQTETGTPYMLYKDSCNRKSN-QQNL 347 Query: 431 APVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAI------NNLDELEELAIL 484 ++ SNLC EI T E+A+C L++ L + +L E+ + Sbjct: 348 GTIKCSNLCTEIVEYT--------SKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKV 399 Query: 485 AVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTF 544 VR L+ ++D YP+P A R +GIGV A + A L + F Sbjct: 400 VVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIF 459 Query: 545 EAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRE 604 E I Y L+AS +LAKEQG + + +KGIL D + + +DW+ L+E Sbjct: 460 ETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDL------WDWKVLKE 513 Query: 605 SIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDY----- 659 I +G+RNS L A MP+ +++QI IEP + + G + V P Sbjct: 514 KIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLT 573 Query: 660 ---------------------------EHLHDAYELLWEMPGNDGYLQLVGIMQKFIDQS 692 + L Y+ +WE+ L++ FIDQS Sbjct: 574 ERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEI-SQKTVLKMAAERGAFIDQS 632 Query: 693 ISANTNYDPSRFPSGKVPMQQLLKDLLTAYKFGVKT-LYYQNTRD 736 S N + + +L +K G+KT +YY TR Sbjct: 633 QSLNIHIAEPNY-------GKLTSMHFYGWKQGLKTGMYYLRTRA 670 >5IM3-A nrPDB Length = 963 Score = 770 bits (1987), Expect = 0.0, Method: Composition-based stats. Identities = 220/807 (27%), Positives = 347/807 (42%), Gaps = 93/807 (11%) Query: 4 NLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGIKTSDIHETII 63 ++ +T+ DGS +++ +++ ++ A EGL V + +E + YDG+ D++ ++ Sbjct: 147 SIRITRADGSLSPLDMGRLNTIISEACEGLAEVDGALIERETLKNLYDGVAEKDVNTALV 206 Query: 64 KAAADLISRDAPDYQYLAARLAIFHLRKKAYG--------------QFEPPALYDHVVKM 109 A L+ R+ P+Y Y+ ARL + LR +A G + AL ++ K Sbjct: 207 MTARTLVERE-PNYSYVTARLLMDTLRAEALGFLGVAESATHHEMAELYAKALPAYIEKG 265 Query: 110 VEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESA 169 E D L E + +++ IDH+RD F+Y ++ L +Y + G +E Sbjct: 266 AEFELVDAKL----KEFDLEKLGKAIDHERDQQFTYLGLQTLYDRYFIHK--DGIRFELP 319 Query: 170 QFLYILVAACL-FSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLI 228 Q ++ VA L RE R FY+ +S+F TP + T Q SSC L Sbjct: 320 QIFFMRVAMGLAIEEKDREAR---AIEFYNLLSSFDYMSSTPTLFNAGTLRPQLSSCYLT 376 Query: 229 ECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTA 288 D L I G+G + +RALGS I+G G +PF K Sbjct: 377 TVPDDLSGIYGAIHDNAMLSKFAGGLGNDWTPVRALGSYIKGTNGKSQGVVPFLKVVNDT 436 Query: 289 VKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLL 348 + +QGG R GA + WHL++E L L+ N G + R M+ I L R+ Sbjct: 437 AVAVNQGGKRKGAVCAYLETWHLDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVF 496 Query: 349 KGEDITLFSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQR----VKAVELFSLMMQ 404 TLFSPSDVP L+D + + FE Y YE S K + V+A +L+ M+ Sbjct: 497 DDGSWTLFSPSDVPDLHDLY---GKAFEERYEYYEALASYGKLKLHKVVQAKDLWRKMLS 553 Query: 405 ERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTL 464 TG ++ D CN SP + V SNLC EI L N EIA+C L Sbjct: 554 MLFETGHPWLTFKDPCNLRSP-QQHVGVVHSSNLCTEITL--------NTNKDEIAVCNL 604 Query: 465 SAFNLGAI-----NNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVIN 519 + NL + +LE+ AVR LD ++D Y +P A+ R +G+G++ Sbjct: 605 GSINLVNHIVDGKLDTAKLEKTVKTAVRMLDNVIDINYYSVPQAQNSNFKHRPVGLGIMG 664 Query: 520 FAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILP 579 F L Y +A ++ EAI YY ++AS +LA E+GA F + +++GILP Sbjct: 665 FQDALYLQHIPYGSDAAIAFADQSMEAISYYAIQASCDLADERGAYQTFQGSLWSQGILP 724 Query: 580 IDTYKKDLDTIANEPLH------YDWEALRESIKTHGLRNSTLSALMPSETSSQISNATN 633 ID+ KK ++ + + DW LRE ++ G+RNS + A+ P+ T + I+ + Sbjct: 725 IDSEKKLIEERGAKYIEVDLSETLDWAPLRERVQK-GIRNSNIMAIAPTATIANITGVSQ 783 Query: 634 GIEPPRGYVSIKASKDGILRQVVPDY--------------------------------EH 661 IEP + +K++ G + P + Sbjct: 784 SIEPTYQNLYVKSNLSGEFTVINPYLVRDLKARGLWDPVMVNDLKYYDGSVQQIERIPQD 843 Query: 662 LHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLTA 721 L D Y +E+ ++ QK+IDQ+ S N + V + A Sbjct: 844 LKDLYATAFEVET-RWIVEAASRRQKWIDQAQSLNLYIAGASGKKLDVTYR-------MA 895 Query: 722 YKFGVKTLYYQNTRDGAEDAQDDLVPS 748 + G+KT YY + + Sbjct: 896 WFRGLKTTYYLRALAATSTEKSTINTG 922 >6CGM-A nrPDB Length = 700 Score = 618 bits (1593), Expect = e-177, Method: Composition-based stats. Identities = 152/674 (22%), Positives = 288/674 (42%), Gaps = 54/674 (8%) Query: 104 DHVVKMVEM-----GKYDNHLLEDYTEEEFKQMDTFID--------HDRDMTF-SYAAVK 149 D++ + K D + Y EEEF + +F D + + F S+ + Sbjct: 39 DYINQNTVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAF 98 Query: 150 QLEGKYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLPT 209 + Y ++ +I E + I + A F+N E +YV + ++ S PT Sbjct: 99 KFYNDYALKTNDKKKILERYE-DRISIVALFFANGDTEKAKEYVNLMIN--QEYQPSTPT 155 Query: 210 PIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIR 269 + +G R + SC L+E DSL+ I+ ++ G+ +N ++RA G I+ Sbjct: 156 FLNAG-RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIK 214 Query: 270 GGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGVEGNR 329 E G + K A + Q G R G+ + ++H ++ L K E R Sbjct: 215 DVENATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVR 274 Query: 330 VRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIR 389 V+ + GV I + + +F P + Y D+ + +Y K+ + ++ Sbjct: 275 VKTLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHM-DEMDMNEMYDKFVDNPRVK 333 Query: 390 KQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPL 449 K+++ +L + R+ +G YI D+ N + I+ V+ SNLC E+ ++ Sbjct: 334 KEKINPRKLLEKLAMLRSESGYPYIMFQDNVN-KVHANNHISKVKFSNLCSEVLQASQVS 392 Query: 450 NDVN-DENGEIAL---CTLSAFNLGAINNLDELEELAILAVRALDALLDYQDY-PIPAAK 504 + + DE EI L C L + N+ + +E+ LA +L + + D PA + Sbjct: 393 SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPAVR 452 Query: 505 RGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGA 564 R +++G+G +N YLA++G Y A + + F + +Y ++ S E+AKE+G Sbjct: 453 RANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAKEKGE 512 Query: 565 -CPWFNETTYAKG-----ILPIDTYKKDLDTIANE------PLHYDWEALRESIKTHGLR 612 + +TYA G + D + + IAN P DW+ L+ + HG+ Sbjct: 513 TFDQYEGSTYATGEYFDKYVSTD-FSPKYEKIANLFEGMHIPTTEDWKKLKAFVAEHGMY 571 Query: 613 NSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVP-----DYEHLHDAYE 667 +S + P+ + S + ++T + P + + + +P ++ +AY+ Sbjct: 572 HSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWFFYKEAYD 631 Query: 668 LLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLTAYKFGVK 727 + + ++ +Q+ IDQ IS + F + + L + L A+ G+K Sbjct: 632 M-----DMFKVVDMIATIQQHIDQGISF------TLFLKDTMTTRDLNRIDLYAHHRGIK 680 Query: 728 TLYYQNTRDGAEDA 741 T+YY T+D +D+ Sbjct: 681 TIYYARTKDTGQDS 694 >1PEQ-A nrPDB Length = 714 Score = 604 bits (1556), Expect = e-173, Method: Composition-based stats. Identities = 152/672 (22%), Positives = 265/672 (39%), Gaps = 54/672 (8%) Query: 113 GKYDNHLLEDYTEEEFKQMDTFIDHDRDMTF-SYAAVKQLEGKYLVQNRVTGEIYESAQF 171 G YD+ +L Y ++ H F ++ + Y ++ E + Sbjct: 70 GYYDDAVLARYDRAFVLRLFEHA-HASGFRFQTFLGAWKFYTSYTLKTFDGKRYLEHFE- 127 Query: 172 LYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECG 231 + + A + Q F+ + PT + G + + SC L+ Sbjct: 128 DRVTMVALTLAQGDETLATQLTDEM--LSGRFQPATPTFLNCG-KQQRGELVSCFLLRIE 184 Query: 232 DSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKS 291 D+++SI ++ ++ + G+ +R G+PI+ E +G IP K + A Sbjct: 185 DNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSY 244 Query: 292 CSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGE 351 +Q G R GA ++ H ++ L K E R++ + GV I + + + Sbjct: 245 ANQLGARQGAGAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENA 304 Query: 352 DITLFSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGR 411 + LFSP D+ Y F D ER Y + D +RK + A + F + + + +G Sbjct: 305 QMALFSPYDIQRRYGKPFGDIAISER-YDELIADPHVRKTYINARDFFQTLAEIQFESGY 363 Query: 412 IYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVND-----ENGEIALCTLSA 466 YI D N +P + SNLC EI L + +D G C L + Sbjct: 364 PYIMFEDTVNRANPI---AGRINMSNLCSEI-LQVNSASRYDDNLDYTHIGHDISCNLGS 419 Query: 467 FNLGAINNLDELEELAILAVRALDALLDYQDY-PIPAAKRGAMGRRTLGIGVINFAYYLA 525 N+ + + ++ A+R L A+ D +P+ G +G+G +N YLA Sbjct: 420 LNIAHVMDSPDIGRTVETAIRGLTAVSDMSHIRSVPSIAAGNAASHAIGLGQMNLHGYLA 479 Query: 526 KHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGA-CPWFNETTYAKG-----ILP 579 + G Y A + T+ F I ++ + S LA+E+G F ++ YA G L Sbjct: 480 REGIAYGSPEALDFTNLYFYTITWHAVHTSMRLARERGKTFAGFAQSRYASGDYFTQYLQ 539 Query: 580 IDTYKKDLDTIA-------NEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQISNAT 632 D K A P W LR+ + +G+ N L A+ P+ + S I++AT Sbjct: 540 DDWQPKTAKVRALFARSGITLPTREMWLKLRDDVMRYGIYNQNLQAVPPTGSISYINHAT 599 Query: 633 NGIEPPRGYVSI-KASKDGILRQVVP-----DYEHLHDAYELLWEMPGNDGYLQLVGIMQ 686 + I P + I K K G + P + + DAY++ G + + Sbjct: 600 SSIHPIVAKIEIRKEGKTGRVYYPAPFMTNENLDMYQDAYDI-----GPEKIIDTYAEAT 654 Query: 687 KFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLTAYKFGVKTLYYQNTRDGAEDAQDDLV 746 + +DQ +S + F + + K + A++ G+K+LYY R A + Sbjct: 655 RHVDQGLSL------TLFFPDTATTRDINKAQIYAWRKGIKSLYYIRLRQLA-------L 701 Query: 747 PSIQDDGCESGA 758 + +GC S A Sbjct: 702 EGTEIEGCVSCA 713 >6DQW-A nrPDB Length = 585 Score = 477 bits (1227), Expect = e-135, Method: Composition-based stats. Identities = 142/646 (21%), Positives = 245/646 (37%), Gaps = 151/646 (23%) Query: 149 KQLEGKYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTFKISLP 208 + L YL++ GE E A I AA R + + + F + + +S+ Sbjct: 50 QILNRGYLLK----GETVEGA-IDRICTAAA-----RRLYKPELKESFVEMIERGWMSIS 99 Query: 209 TPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPI 268 +P+ + + T SC + D ++ I ++ G G +R GS + Sbjct: 100 SPVWANMGTERGLPISCFNVHVPDKIEGITHKLGEVIMQTKIGGGTSGYFGELRERGSAV 159 Query: 269 RGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKNNRGVEGN 328 +G + F K F TA+ + SQGGVR GA + + H ++E L +K+ GN Sbjct: 160 TD-NGKSSGAVSFMKLFDTAMDTISQGGVRRGAFAAYLDIDHPDIEEFLKIKSI----GN 214 Query: 329 RVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFADQEEFERLYTKYEKDDSI 388 ++++ G+ + ++ G+ Sbjct: 215 PIQNLFTGICVPDYWMQEMIDGDA------------------------------------ 238 Query: 389 RKQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSP--FDPAIAPVRQSNLCLEIALPT 446 ++++ +++ R G YI D+ N + P + + SNLC EI LP+ Sbjct: 239 -----DKRQIWAKVLESRQQKGLPYIFFSDNVNKNKPQVYKDQNLRINASNLCSEIMLPS 293 Query: 447 KPLNDVNDENGEIALCTLSAFNLGAINNLDELEELAILAVRALDALLDY------QDYPI 500 + E +C LS+ NL + E LA+ LDA+L +Y + Sbjct: 294 --------THDESFICCLSSMNLELYEEWKDTEA-VKLAIFFLDAVLQEFIEKTEGNYYL 344 Query: 501 PAAKRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAK 560 AA + A R LG+GV+ + YL K+ + A T + F+ I KAS ELA+ Sbjct: 345 SAANKFAKRHRALGLGVLGWHSYLQKNMIPFEGMEAKMKTTEIFKHISDKADKASQELAR 404 Query: 561 EQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTHGLRNSTLSALM 620 I EP E +K +G RN+T A+ Sbjct: 405 -----------------------------IYGEP---------ELLKGYGRRNTTTMAIA 426 Query: 621 PSETSSQISNATN-GIEPPRGYVS-IKASKDGILRQVV---------------------- 656 P+ +SS I T+ GIEP SK +R+ Sbjct: 427 PTTSSSAILGQTSPGIEPFSSNYYKAGLSKGNFMRKNKYLKKLLEEKGLDNEEVWRGIML 486 Query: 657 --PDYEHL-------HDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSG 707 +H+ D ++ E+ + +Q GI QKF+DQ S N N Sbjct: 487 NGGSVQHMSQLTQQEKDVFKTFKEISQLE-IVQQAGIRQKFVDQGQSLNLNI------PA 539 Query: 708 KVPMQQLLKDLLTAYKFGVKTLYYQNTRDGAEDAQDDLVPSIQDDG 753 ++ ++ + + ++ A++ GVK+LYYQ ++ +++ LV + Sbjct: 540 ELAIKDVNRLMIEAWQQGVKSLYYQRSQSVSKELVTSLVSCSSCES 585 >6DQX-A nrPDB Length = 574 Score = 474 bits (1220), Expect = e-134, Method: Composition-based stats. Identities = 138/617 (22%), Positives = 224/617 (36%), Gaps = 144/617 (23%) Query: 180 LFSNYPRETRLQ-YVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSIN 238 + + + ++ Y +FY ++ SL +PI S SC GDS+ I Sbjct: 59 IAEHAEHKLGIEGYADKFYHYMARGYFSLSSPIWSNFGLDRGLPISCFGSYIGDSIHEIM 118 Query: 239 ATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVR 298 T++ + G G IR GS I+ G F K F T + SQG R Sbjct: 119 VTTAEVGMMSKIGGGTSAYFGDIRPRGSAIKN-NGKSDGSFNFSKLFDTVIDVISQGTSR 177 Query: 299 GGAATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSP 358 G + + H +++ L + EGN ++ M YGV + + G+ Sbjct: 178 KGQFAGYIDIEHGDIDEWLDIH----TEGNPIQLMYYGVCVGHDWLESMKAGDPYK---- 229 Query: 359 SDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVD 418 +L++ ++Q + TG Y+ D Sbjct: 230 -------------------------------------RQLWAKLLQRKTETGIPYLFFKD 252 Query: 419 HCNTHSP--FDPAIAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAINNLD 476 + N P + V SNLC EI LP+ N E +C LS+ NL + Sbjct: 253 NANAGRPDVYKDKNMTVHASNLCTEIMLPS--------SNDESFVCCLSSMNLLYFDEWK 304 Query: 477 ELEELAILAVRALDALLDY-----QDYP-IPAAKRGAMGRRTLGIGVINFAYYLAKHGKR 530 + E +L LD ++ +D P + A R A R LG+GV+ + YL + Sbjct: 305 DTEAPEVLTY-FLDVVMSEFIEKSKDMPFLDRAHRFATRHRALGLGVLGWHSYLQANNIA 363 Query: 531 YSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTI 590 + A + F+ +Q LKAS ELAK G Sbjct: 364 FDSFQAMQKNNLIFKTLQEKTLKASQELAKRFGE-------------------------- 397 Query: 591 ANEPLHYDWEALRESIKTHGLRNSTLSALMPSETSSQISNA-TNGIEPPRGYVSIK---- 645 E +K +G RN+TL ++ P+++SS I + + +EP + +K Sbjct: 398 ------------PEILKGYGRRNTTLMSIAPTKSSSFILGSVSPSVEPFKSNYYVKDLAK 445 Query: 646 ---ASKDGILRQVVPDYEHLHDAYELLWEMPGNDG------------------------- 677 K+ L +++ E D E+ + NDG Sbjct: 446 IKTVYKNPFLEKLLQ--EKGLDTEEIWESILHNDGSVQHLEQLTDEEKEVFKTFSEISQL 503 Query: 678 -YLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLTAYKFGVKTLYYQNTRD 736 +Q QK+IDQ S N P+ P + L + LTA + G+K++YYQ + Sbjct: 504 SVIQQAAQRQKYIDQGQSINIMVHPA------TPARDLNQLYLTAEELGLKSIYYQYSMS 557 Query: 737 GAEDAQDDLVPSIQDDG 753 A+ +L+ +G Sbjct: 558 AAQVFNRNLLSCSSCEG 574 >3O0O-A nrPDB Length = 644 Score = 368 bits (945), Expect = e-102, Method: Composition-based stats. Identities = 125/617 (20%), Positives = 220/617 (35%), Gaps = 140/617 (22%) Query: 190 LQYVKRFYDAVSTFKISLPTPIMSGVR---------------------------TPTRQF 222 ++ F+ + +P + Sbjct: 72 KEWEDIFFRVLKARLFIPNSPTLFNAGLGVKHDLLWKPIDQMTLEDYEEIYRSRNHLHML 131 Query: 223 SSCVLIECGDSLDSINATSSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFY 282 S+C ++ GDS++ I G+G N +R GS + G +G + F Sbjct: 132 SACFVVPVGDSIEEIFEAVKEYALITKVGGGVGSNFSELRPKGSFVAGTHGKASGPVSFM 191 Query: 283 KHFQTAVKSCSQGGVRGGAATLFYPMWHLEVESLLVLKN-NRGVEGNRVRHMDYGVQINK 341 F +A+ QG R GA + H ++E + K N G ++ G ++K Sbjct: 192 HVFNSAISVVKQGSRRRGALMGILNINHPDIEEFIDAKKENTGEAVLNFFNLSVGFPMDK 251 Query: 342 LMYTRLLKGEDITLFSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSL 401 ++ LY+ + E E + + +IRK +VK ELF Sbjct: 252 -----------------KEILKLYE----EDGELELSHPR----STIRK-KVKIRELFRK 285 Query: 402 MMQERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVNDEN--GEI 459 + +G DP +A + + N P P +N N GEI Sbjct: 286 IATNAWKSG----------------DPGLAFLGEMNKY----YPLYPHRKINSTNPCGEI 325 Query: 460 ALCTLSAFNLGAIN----------NLDELEELAILAVRALDALLDYQDYPIPAAKRGAMG 509 L A NLG+I+ +L+ L+EL +AVR LD ++D +PI + Sbjct: 326 GLSDYEACNLGSIDVAKFYNNGFVDLEALQELVQIAVRFLDNVIDVNVFPIDKITKAVKE 385 Query: 510 RRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFN 569 R LG+G++ FA L K Y+ A + I + + S EL KE+G P Sbjct: 386 SRRLGLGIMGFADLLYKLEIPYNSQEARDFAANLMAFIALHAHRTSYELGKEKGNFP--- 442 Query: 570 ETTYAKGILPIDTYKKDLDTI--ANEPLHYDWEALRESIK--THGLRNSTLSALMPSETS 625 +L I Y+ + + + A +YD E +RE +K RN L + P+ + Sbjct: 443 -------LLEISRYRTEDNFVPFAMGMSNYDDE-IREVMKMTKEFRRNVALLTIAPTGSI 494 Query: 626 SQISNATNGIEPPRGYVSIKAS------KDGILR-------QVVPDYEH----------- 661 S I++ ++G+EP + K+ +L ++ P+ Sbjct: 495 SNIADTSSGLEPNFLLAYTRFVTKEDGTKEPLLYVNQVLREKLNPEILKRIEKELIEKGS 554 Query: 662 LHDAYELLWEMPG---------NDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQ 712 L D ++ ++ +L + Q+++D +IS N + Sbjct: 555 LKDIPDVPEKIKKVFVVALDIDPMDHLLMQDAFQRYVDNNISKTINM------PQSATVD 608 Query: 713 QLLKDLLTAYKFGVKTL 729 +L L A + V+ + Sbjct: 609 DVLNVYLEALRTNVRGI 625 >1L1L-A nrPDB Length = 739 Score = 42.1 bits (97), Expect = 8e-04, Method: Composition-based stats. Identities = 64/398 (16%), Positives = 130/398 (32%), Gaps = 82/398 (20%) Query: 256 INAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMWHLEVES 315 ++ IR G+ I G +G +P + + GG T + ++ + Sbjct: 252 LDLSDIRPYGAEIHGFGGTASGPMPLISMLLDVNEVLN--NKAGGRLTA---VDAADICN 306 Query: 316 LLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYDAFFADQEEF 375 L+ K R + G ++ + Q++ Sbjct: 307 LIG-KAVVAGNVRRSAELALGSNDDQDFISM------------------------KQDQE 341 Query: 376 ERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPAI----- 430 + ++ ++ ++S+ A + + G I N+D + Sbjct: 342 KLMHHRWASNNSVAVD--SAFSGYQPIAAGIRENGEPGIVNLDLSKNYGRIVDGYQAGID 399 Query: 431 APVRQSNLCLEIALPTKPLNDVNDENGEIALCTL-SAFNLGAINNLDELEELAILAVRAL 489 V +N C EI+L NGE C L F L A +L+E+ LA R Sbjct: 400 GDVEGTNPCGEISLA----------NGEP--CNLFEVFPLIAEEQGWDLQEVFALAARYA 447 Query: 490 DALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLA-KHGKRYSDGSANNLTHKTFEAIQ 548 + + Y ++ R +GI + +L + G R G ++ +T EAI Sbjct: 448 KRVT-FSPYDWEISREIIQKNRRIGISMSGIQDWLLTRLGNRVVTGFKDDFDPETHEAI- 505 Query: 549 YYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKT 608 P +++ K +D + + D + + Sbjct: 506 ---------------KVPVYDKRAI-----------KMVDQLYKAVVKADQDYSKTLGCN 539 Query: 609 HGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKA 646 ++++T + PS T ++++ A+ G+ G I+ Sbjct: 540 ESIKHTT---VKPSGTVAKLAGASEGMHFHYGAYLIQR 574 >3OHM-B nrPDB Length = 885 Score = 37.5 bits (85), Expect = 0.024, Method: Composition-based stats. Identities = 47/364 (12%), Positives = 94/364 (25%), Gaps = 46/364 (12%) Query: 395 AVELFSLMMQERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVND 454 +L ++ + R D P + + + + +S+ E P+ P Sbjct: 455 PQDLMGRILVKNKKRHRPSAGGPDSAGRKRPLEQSNSALSESSAATE---PSSPQLGSPS 511 Query: 455 ENGEIALCTLSAFNLGAINNLDELEELAILAVRALDA------------------LLDYQ 496 + L L LE L L+ + Sbjct: 512 SDSCPGLSNGEEVGL----EKPSLEPQKSLGDEGLNRGPYVLGPADREDEEEDEEEEEQT 567 Query: 497 DYPIPAAKRGAMGRRTLGIGVIN-FAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKAS 555 D P G ++ Y+ ++ A +K FE + KA Sbjct: 568 DPKKPTTDEGTASSEVNATEEMSTLVNYI--EPVKFKSFEAARKRNKCFEMSSFVETKAM 625 Query: 556 NELAKEQGACPWFNETTY-----------AKGILPIDTYKKDLDTIANEPLHYDWE-ALR 603 +L K +N+ + +P + +A D L Sbjct: 626 EQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLN 685 Query: 604 ESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDYEHLH 663 + + R+ L + +P + + + +V+ Sbjct: 686 AGVFEYNGRSGYLLKP------EFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSD 739 Query: 664 DAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLTAYK 723 + E+ + + Q S N +D F KV + L + A++ Sbjct: 740 RKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFE 799 Query: 724 FGVK 727 G K Sbjct: 800 EGGK 803 >4QJ3-B nrPDB Length = 793 Score = 34.4 bits (77), Expect = 0.20, Method: Composition-based stats. Identities = 29/215 (13%), Positives = 59/215 (27%), Gaps = 18/215 (8%) Query: 525 AKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTY----------- 573 ++ A +K FE + KA +L K +N+ Sbjct: 498 YIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVD 557 Query: 574 AKGILPIDTYKKDLDTIANEPLHYDWE-ALRESIKTHGLRNSTLSALMPSETSSQISNAT 632 + +P + +A D L + + R+ L + Sbjct: 558 SSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKP------EFMRRPD 611 Query: 633 NGIEPPRGYVSIKASKDGILRQVVPDYEHLHDAYELLWEMPGNDGYLQLVGIMQKFIDQS 692 +P + + + +V+ + E+ + + Q Sbjct: 612 KSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQG 671 Query: 693 ISANTNYDPSRFPSGKVPMQQLLKDLLTAYKFGVK 727 S N +D F KV + L + A++ G K Sbjct: 672 NSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGK 706 >1XI9-A nrPDB Length = 406 Score = 32.9 bits (73), Expect = 0.58, Method: Composition-based stats. Identities = 20/135 (14%), Positives = 45/135 (33%), Gaps = 12/135 (8%) Query: 307 PMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPSDVPGLYD 366 W +++ ++ + ++ L + TL ++ G Y+ Sbjct: 158 EDWQPDID---DIRKKITDRTKAIAVINPNNPTGALYDKK-------TLEEILNIAGEYE 207 Query: 367 AFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERASTG--RIYIQNVDHCNTHS 424 E ++ + + E + V + + + + +TG Y+ VD N S Sbjct: 208 IPVISDEIYDLMTYEGEHISPGSLTKDVPVIVMNGLSKVYFATGWRLGYMYFVDPENKLS 267 Query: 425 PFDPAIAPVRQSNLC 439 AI + + LC Sbjct: 268 EVREAIDRLARIRLC 282 >5BRL-A nrPDB Length = 210 Score = 31.4 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 21/108 (19%), Positives = 34/108 (31%), Gaps = 10/108 (9%) Query: 533 DGSANNLTHKTFEAIQYYLLKASN-ELAKE-------QGACPWFNETTYAKGILPIDTYK 584 A+ T IQY+ +K +AK+ + FN Y + D Sbjct: 9 SDVASISTKLQNTLIQYHSIKEDEWRVAKKVKDVTVWRKPSEEFNGYLYKAQGVMDDVVN 68 Query: 585 KDLDTIANEPLHYDWEALRE--SIKTHGLRNSTLSALMPSETSSQISN 630 +D I P DW+ L + H N + + I + Sbjct: 69 NVIDHIRPGPWRLDWDRLMTSLDVLEHFEENCCVMRYTTAGQLDNIIS 116 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.119 0.282 Lambda K H 0.267 0.0364 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 23,567,311 Number of Sequences: 36641 Number of extensions: 868464 Number of successful extensions: 2517 Number of sequences better than 10.0: 15 Number of HSP's better than 10.0 without gapping: 23 Number of HSP's successfully gapped in prelim test: 10 Number of HSP's that attempted gapping in prelim test: 2327 Number of HSP's gapped (non-prelim): 44 length of query: 761 length of database: 10,336,785 effective HSP length: 105 effective length of query: 656 effective length of database: 6,489,480 effective search space: 4257098880 effective search space used: 4257098880 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 63 (29.0 bits)