BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P00390 (522 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2AAQ-A nrPDB 994 0.0 6N7F-A nrPDB 475 e-134 5VDN-A nrPDB 460 e-130 1GEU-A nrPDB 456 e-128 2R9Z-A nrPDB 443 e-125 5V36-A nrPDB 442 e-124 6B4O-A nrPDB 441 e-124 5U1O-A nrPDB 438 e-123 2HQM-A nrPDB 430 e-121 6DU7-A nrPDB 421 e-118 1ONF-A nrPDB 327 8e-90 1ZDL-A nrPDB 315 3e-86 3O0H-A nrPDB 304 5e-83 4DNA-A nrPDB 289 2e-78 2WOV-A nrPDB 283 1e-76 2X8H-A nrPDB 275 2e-74 4LA1-A nrPDB 266 1e-71 1FEC-A nrPDB 263 1e-70 5W1J-A nrPDB 262 3e-70 4NEW-A nrPDB 258 6e-69 2NVK-X nrPDB 255 3e-68 2YAU-A nrPDB 253 2e-67 4KPR-E nrPDB 244 1e-64 4B1B-A nrPDB 241 5e-64 2CFY-A nrPDB 241 7e-64 5X1Y-B nrPDB 223 2e-58 5TR3-A nrPDB 185 5e-47 3LAD-A nrPDB 184 8e-47 2YQU-A nrPDB 182 4e-46 1DXL-A nrPDB 181 5e-46 1EBD-A nrPDB 179 2e-45 2EQ6-A nrPDB 175 4e-44 5U8W-A nrPDB 173 2e-43 3URH-A nrPDB 172 4e-43 5J5Z-A nrPDB 171 9e-43 4JDR-A nrPDB 166 2e-41 4YWO-A nrPDB 162 3e-40 6CMZ-A nrPDB 161 8e-40 1V59-A nrPDB 160 1e-39 6AON-A nrPDB 158 7e-39 6BZ0-A nrPDB 155 5e-38 1ZK7-A nrPDB 149 3e-36 1LVL-A nrPDB 143 2e-34 3II4-A nrPDB 138 5e-33 1OJT-A nrPDB 133 2e-31 5U25-A nrPDB 129 3e-30 2QAE-A nrPDB 127 1e-29 3Q6J-A nrPDB 113 2e-25 1XDI-A nrPDB 103 3e-22 3L8K-A nrPDB 96 3e-20 3IC9-A nrPDB 94 2e-19 3CGD-A nrPDB 61 1e-09 1YQZ-A nrPDB 56 4e-08 4CBQ-A nrPDB 54 2e-07 3NTA-A nrPDB 52 8e-07 2CDU-A nrPDB 52 9e-07 3ISH-A nrPDB 51 1e-06 5M5J-A nrPDB 51 1e-06 2Q7V-A nrPDB 50 2e-06 4FX9-A nrPDB 50 2e-06 5UWY-A nrPDB 49 4e-06 3F8P-A nrPDB 49 4e-06 2BC1-A nrPDB 49 7e-06 4ZN0-A nrPDB 47 2e-05 1F6M-A nrPDB 47 2e-05 6BWT-A nrPDB 46 4e-05 5JFC-L nrPDB 45 7e-05 4YRY-B nrPDB 45 7e-05 4GCM-A nrPDB 45 8e-05 5MJK-A nrPDB 45 9e-05 5VJ7-A nrPDB 45 1e-04 3LZX-A nrPDB 44 1e-04 5JCN-A nrPDB 44 1e-04 1Q1R-A nrPDB 44 1e-04 3IWA-A nrPDB 44 2e-04 1VDC-A nrPDB 43 3e-04 5ER0-A nrPDB 42 8e-04 5W4C-A nrPDB 42 9e-04 5UTH-A nrPDB 41 0.001 5YGQ-A nrPDB 41 0.001 3D8X-A nrPDB 41 0.001 6BPY-A nrPDB 40 0.002 3ICS-A nrPDB 40 0.002 5U63-A nrPDB 40 0.003 4YKF-A nrPDB 40 0.003 1FL2-A nrPDB 39 0.004 2A87-A nrPDB 39 0.005 1NHQ-A nrPDB 39 0.007 6GAR-A nrPDB 39 0.007 3LXD-A nrPDB 38 0.010 6GAS-A nrPDB 37 0.023 3R9U-A nrPDB 37 0.027 2V3B-A nrPDB 36 0.032 1XHC-A nrPDB 36 0.032 5USX-A nrPDB 35 0.056 4EMJ-A nrPDB 35 0.070 1NAA-A nrPDB 35 0.077 3UKH-A nrPDB 35 0.094 6C26-B nrPDB 35 0.11 4MO2-B nrPDB 34 0.19 2ZBW-A nrPDB 33 0.33 6CR0-A nrPDB 32 0.52 2YVG-A nrPDB 32 0.53 4YNU-A nrPDB 32 0.94 5KVH-A nrPDB 32 0.97 3KLJ-A nrPDB 31 1.2 2BXR-A nrPDB 31 1.5 2VDC-G nrPDB 31 1.6 2WHD-A nrPDB 30 1.7 5BR7-A nrPDB 30 2.0 3MJ4-A nrPDB 30 2.3 1I8T-A nrPDB 30 2.5 5EQD-A nrPDB 30 2.6 1O5W-A nrPDB 30 2.7 3LP8-A nrPDB 30 3.1 5KXJ-A nrPDB 30 3.3 5MIU-A nrPDB 30 3.4 3NK2-X nrPDB 29 3.9 4Y4N-A nrPDB 29 4.8 3GG2-A nrPDB 29 6.4 3G17-A nrPDB 28 6.9 2GMH-A nrPDB 28 7.3 5M7S-A nrPDB 28 8.8 4H7U-A nrPDB 28 9.3 >2AAQ-A nrPDB Length = 479 Score = 994 bits (2570), Expect = 0.0, Method: Compositional matrix adjust. Identities = 479/479 (100%), Positives = 479/479 (100%) Query: 44 MACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCV 103 MACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCV Sbjct: 1 MACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCV 60 Query: 104 NVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLT 163 NVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLT Sbjct: 61 NVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLT 120 Query: 164 KSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDG 223 KSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDG Sbjct: 121 KSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDG 180 Query: 224 FFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELE 283 FFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELE Sbjct: 181 FFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELE 240 Query: 284 NAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLS 343 NAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLS Sbjct: 241 NAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLS 300 Query: 344 LNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKED 403 LNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKED Sbjct: 301 LNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKED 360 Query: 404 SKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVM 463 SKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVM Sbjct: 361 SKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVM 420 Query: 464 KMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 522 KMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR Sbjct: 421 KMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 479 >6N7F-A nrPDB Length = 453 Score = 475 bits (1222), Expect = e-134, Method: Compositional matrix adjust. Identities = 243/463 (52%), Positives = 317/463 (68%), Gaps = 16/463 (3%) Query: 62 VASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSE 121 V YDY+VIGGGS G+ASA RAA GA+ + E ++GGTCVN+GCVPKKVMW A ++ Sbjct: 5 VIPYDYIVIGGGSAGIASANRAAMHGAKVLLAEGKEIGGTCVNLGCVPKKVMWYGAQVAD 64 Query: 122 FMHDHA-DYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP 180 + +A DYGF E F+++ +K R AY+ R++A Y+ ++ ++ I +A F Sbjct: 65 ILGTYAKDYGFDFKEKAFDFKQLKANRQAYIDRIHASYERGFEQNGVDRIYDYAVFKD-- 122 Query: 181 KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG 240 T+E++G+ YTAPHILIATGG P P I GA GI+SDGFF L+E+P R+ +VGAG Sbjct: 123 AHTVEIAGQLYTAPHILIATGGHPVFP---DIEGAQYGISSDGFFALDEVPKRTAVVGAG 179 Query: 241 YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQV-KEVK 299 YIAVE+AG+L ALGSKT L IRHD+ LRSFD I +E+ G + ++V K VK Sbjct: 180 YIAVELAGVLHALGSKTDLFIRHDRPLRSFDKTIVDVLVDEMAVNGPRLHTHAEVAKVVK 239 Query: 300 KTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIV 359 T L + + +VD L+WAIGR PN + SL+K G+ +DKG+I Sbjct: 240 NTDESLTLYLKDGQE---------VEVDQLIWAIGRKPNLEGFSLDKTGVTLNDKGYIET 290 Query: 360 DEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHP 419 D ++NT+VKGIYAVGDV GK LTPVA+AAGR+L+ RLF K D KLDY N+ TV+FSHP Sbjct: 291 DAYENTSVKGIYAVGDVNGKLALTPVAVAAGRRLSERLFNGKTDEKLDYQNVATVIFSHP 350 Query: 420 PIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHM 479 IG+VGL+E+ A+ +YG E VKTY + FT M+ A+T + C+MK+V EK+VG+H Sbjct: 351 VIGSVGLSEEAAVKQYGQEAVKTYQSRFTSMFTAITNHRQPCLMKLVTVGDTEKIVGLHG 410 Query: 480 QGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 522 G G DEM+QGFAVA+KMGATKADFDNTVAIHPT SEE VT+R Sbjct: 411 IGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR 453 >5VDN-A nrPDB Length = 463 Score = 460 bits (1184), Expect = e-130, Method: Compositional matrix adjust. Identities = 249/462 (53%), Positives = 320/462 (69%), Gaps = 20/462 (4%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 YDYL IGGGSGG+AS RAA G + A++E+ +LGGTCVNVGCVPKKVMW+ A +E +H Sbjct: 18 YDYLAIGGGSGGIASINRAAMYGKKCALIEAKQLGGTCVNVGCVPKKVMWHAAQIAEAIH 77 Query: 125 DHA-DYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 + DYGF + F+W+ + R AY+ R++ Y+ L + +++I+G A F T Sbjct: 78 LYGPDYGFDTTVNHFDWKKLIANRTAYIDRIHQSYERGLGNNKVDVIQGFARFVD--AHT 135 Query: 184 IEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIA 243 +EV+G+ TA HILIATGG PS P IPGA GI SDGFF+L+E+P R +VGAGYIA Sbjct: 136 VEVNGETITADHILIATGGRPSHP---DIPGAEYGIDSDGFFELDEMPKRVAVVGAGYIA 192 Query: 244 VEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLS 303 VE+AG+L+ LG++T L +R LR+FD +I E + G ++ S K V K Sbjct: 193 VEIAGVLNGLGTETHLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESVPKAVIKNAD 252 Query: 304 G---LEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD 360 G L++ T V VD L+WAIGR P T +L+L+ G++T+DKG+I VD Sbjct: 253 GSLTLQLENGTEVT-----------VDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVD 301 Query: 361 EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP 420 +FQNTNVKGIYAVGD G LTPVA+AAGR+L+ RLF K D LDY+NIPTVVFSHPP Sbjct: 302 KFQNTNVKGIYAVGDNTGVVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPP 361 Query: 421 IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ 480 IGT+GLTE +A K+G + VK Y++SFT MY AVT+ + C MK+VC EEK+VGIH Sbjct: 362 IGTIGLTEPQAREKFGDDQVKVYTSSFTAMYSAVTQHRQPCRMKLVCVGAEEKIVGIHGI 421 Query: 481 GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 522 G G DE+LQGFAVA+KMGATK DFDNTVAIHPT++EE VT+R Sbjct: 422 GFGMDEILQGFAVAMKMGATKKDFDNTVAIHPTAAEEFVTMR 463 >1GEU-A nrPDB Length = 450 Score = 456 bits (1173), Expect = e-128, Method: Compositional matrix adjust. Identities = 250/462 (54%), Positives = 315/462 (68%), Gaps = 20/462 (4%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 YDY+ IGGGSGG+AS RAA G + A++E+ +LGGTCVNVGCVPKKVMW+ A E +H Sbjct: 5 YDYIAIGGGSGGIASINRAAMYGQKCALIEAKELGGTCVNVGCVPKKVMWHAAQIREAIH 64 Query: 125 DHA-DYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 + DYGF + KFNW + R AY+ R++ Y+N L K+++++I+G A F D K T Sbjct: 65 MYGPDYGFDTTINKFNWETLIASRTAYIDRIHTSYENVLGKNNVDVIKGFARFV-DAK-T 122 Query: 184 IEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIA 243 +EV+G+ TA HILIATGG PS P IPG GI SDGFF L LP R +VGAGYI Sbjct: 123 LEVNGETITADHILIATGGRPSHP---DIPGVEYGIDSDGFFALPALPERVAVVGAGYIG 179 Query: 244 VEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLS 303 VE+ G+++ LG+KT L D L SFD MIS E + G ++ + K V K Sbjct: 180 VELGGVINGLGAKTHLFEMFDAPLPSFDPMISETLVEVMNAEGPQLHTNAIPKAVVKNTD 239 Query: 304 G---LEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD 360 G LE+ GR VDCL+WAIGR P +++L G++T++KG+I+VD Sbjct: 240 GSLTLELE-----DGRSET------VDCLIWAIGREPANDNINLEAAGVKTNEKGYIVVD 288 Query: 361 EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP 420 ++QNTN++GIYAVGD G LTPVA+AAGR+L+ RLF K D LDY+NIPTVVFSHPP Sbjct: 289 KYQNTNIEGIYAVGDNTGAVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPP 348 Query: 421 IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ 480 IGTVGLTE +A +YG + VK Y +SFT MY AVT + C MK+VC EEK+VGIH Sbjct: 349 IGTVGLTEPQAREQYGDDQVKVYKSSFTAMYTAVTTHRQPCRMKLVCVGSEEKIVGIHGI 408 Query: 481 GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 522 G G DEMLQGFAVA+KMGATK DFDNTVAIHPT++EE VT+R Sbjct: 409 GFGMDEMLQGFAVALKMGATKKDFDNTVAIHPTAAEEFVTMR 450 >2R9Z-A nrPDB Length = 463 Score = 443 bits (1140), Expect = e-125, Method: Compositional matrix adjust. Identities = 224/459 (48%), Positives = 306/459 (66%), Gaps = 16/459 (3%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 +D + IGGGSGGLA A +AA G R A++ES LGGTCVNVGCVPKKVMW + +E + Sbjct: 5 FDLIAIGGGSGGLAVAEKAAAFGKRVALIESKALGGTCVNVGCVPKKVMWYASHLAEAVR 64 Query: 125 DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTI 184 D +G + G +W + RD Y+ +N+ + + + I + GHA F TI Sbjct: 65 DAPGFGVQASGGTLDWPRLVAGRDRYIGAINSFWDGYVERLGITRVDGHARFVD--AHTI 122 Query: 185 EVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAV 244 EV G++ +A HI+IATGG P P ++PGA LGITSDGFF L++ P R I+GAGYI + Sbjct: 123 EVEGQRLSADHIVIATGGRPIVP---RLPGAELGITSDGFFALQQQPKRVAIIGAGYIGI 179 Query: 245 EMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEV-LKFSQVKEVKKTLS 303 E+AG+L + GS+ +++ D++L FD ++S E + G+E L+F+ V +++ Sbjct: 180 ELAGLLRSFGSEVTVVALEDRLLFQFDPLLSATLAENMHAQGIETHLEFA-VAALERDAQ 238 Query: 304 GLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQ 363 G + + A G T + D ++WA+GR PNT+DL L GI+ G + D +Q Sbjct: 239 G---TTLVAQDG-----TRLEGFDSVIWAVGRAPNTRDLGLEAAGIEVQSNGMVPTDAYQ 290 Query: 364 NTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGT 423 NTNV G+YA+GD+ G+ LTPVAIAAGR+LA RLF+ + + KLDY+NIPTVVF+HPP+ Sbjct: 291 NTNVPGVYALGDITGRDQLTPVAIAAGRRLAERLFDGQSERKLDYDNIPTVVFAHPPLSK 350 Query: 424 VGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLG 483 VGL+E EA + G + + Y TSFTPM +A+ + K MK+VCA E++VVG+H+ G G Sbjct: 351 VGLSEPEARERLG-DVLTVYETSFTPMRYALNEHGPKTAMKLVCAGPEQRVVGVHVIGDG 409 Query: 484 CDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 522 DEMLQGFAVAVKMGATKADFDNTVAIHP S+EELVTL+ Sbjct: 410 ADEMLQGFAVAVKMGATKADFDNTVAIHPGSAEELVTLK 448 >5V36-A nrPDB Length = 453 Score = 442 bits (1137), Expect = e-124, Method: Compositional matrix adjust. Identities = 236/466 (50%), Positives = 314/466 (67%), Gaps = 26/466 (5%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFM 123 YDY+VIGGGSGG+ASA RAA GA+ + E ++GGTCVNVGCVPKKVMW A +E + Sbjct: 7 QYDYIVIGGGSGGIASANRAAMHGAKVILFEGKQVGGTCVNVGCVPKKVMWYGAQVAETI 66 Query: 124 HDHA-DYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKP 182 +++A DYGF F++ V+K+ R AY+ R++ Y+ + +E + G+A F Sbjct: 67 NNYAADYGFDVTTQAFHFDVLKQNRQAYIDRIHDSYERGFDSNGVERVYGYATFVD--AH 124 Query: 183 TIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYI 242 T+EV+G+ YTAPHILIATGG P IPG+ GITSDGFF+L+ +P R+ +VGAGYI Sbjct: 125 TVEVAGEHYTAPHILIATGGHALLP---DIPGSEYGITSDGFFELDAIPKRTAVVGAGYI 181 Query: 243 AVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTL 302 AVE++GIL ALGS+T L +R D+ LR FD I +E++ G + FS KEV K Sbjct: 182 AVEISGILHALGSETHLFVRRDRPLRKFDKEIVGTLVDEMKKDGPHLHTFSVPKEVIKNT 241 Query: 303 SGLEVSMVTAVPGRLPVMTMIPD------VDCLLWAIGRVPNTKDLSLNKLGIQTDDKGH 356 +T+I + VD L+WAIGR NTK +L G+ D +G Sbjct: 242 DN--------------SLTLILENGEEYTVDTLIWAIGRAANTKGFNLEVTGVTLDSRGF 287 Query: 357 IIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVF 416 I D F+NTNV+G+YA+GDV GK LTPVA+ AGR+L+ RLF +K +K+DY ++ TV+F Sbjct: 288 IATDAFENTNVEGLYALGDVNGKLELTPVAVKAGRQLSERLFNHKPQAKMDYKDVATVIF 347 Query: 417 SHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVG 476 SHP IG++GL+E+ A+ +YG ENV Y ++FT MY AVT + C MK+V ++EK+VG Sbjct: 348 SHPVIGSIGLSEEAALDQYGEENVTVYRSTFTSMYTAVTSHRQACKMKLVTVGEDEKIVG 407 Query: 477 IHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 522 +H G G DEM+QGFAVA+KMGATKADFDNTVAIHPT SEE VT+R Sbjct: 408 LHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR 453 >6B4O-A nrPDB Length = 452 Score = 441 bits (1135), Expect = e-124, Method: Compositional matrix adjust. Identities = 237/465 (50%), Positives = 309/465 (66%), Gaps = 14/465 (3%) Query: 59 AGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAV 118 + A+ +YDY+VIGGGSGG+ASA RA GA ++E +++GGTCVNVGCVPKKVMW + Sbjct: 1 SNAMKTYDYIVIGGGSGGIASANRAGMHGANVLLIEGNEIGGTCVNVGCVPKKVMWQASS 60 Query: 119 HSEFMH-DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFT 177 E M D A YGF F+++ + E R+ Y+ L+ Y L ++IE I G+A FT Sbjct: 61 MMEMMERDTAGYGFDVEIKNFSFKQLVENREKYIDFLHGAYNRGLDSNNIERIHGYATFT 120 Query: 178 SDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIV 237 + TIEV+G +YTAPHILIATGG P + IPG + S+GFF LEE+P R V V Sbjct: 121 GEQ--TIEVNGTEYTAPHILIATGGRPK---KLGIPGEEYALDSNGFFALEEMPKRVVFV 175 Query: 238 GAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKE 297 GAGYIA E+AG L LG++T RH++ LRSFD M+S E + G+++ + + Sbjct: 176 GAGYIAAELAGTLHGLGAETHWAFRHERPLRSFDDMLSEKVVERYQEMGMQIHPNATPAK 235 Query: 298 VKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHI 357 ++KT V + T D +++ GR PNT L L + D+KG++ Sbjct: 236 IEKTAQN---EYVITFENGESITT-----DAVIFGTGRQPNTDQLGLENTKVALDEKGYV 287 Query: 358 IVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFS 417 VD+FQNT GIYAVGDV GK LTPVAIAAGR+L+ RLF + D LDYN +PTVVF+ Sbjct: 288 KVDKFQNTTQNGIYAVGDVIGKIDLTPVAIAAGRRLSERLFNGQTDLYLDYNLVPTVVFT 347 Query: 418 HPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGI 477 HPP+ T+GLTE A+ +YG + VK Y +SFTPMY A+ + + KC MK++C KEEK+VG+ Sbjct: 348 HPPVATIGLTEKAALEEYGEDQVKIYRSSFTPMYFALGEYRQKCDMKLICVGKEEKIVGL 407 Query: 478 HMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 522 H G+G DEMLQGFAVA+KMGATKADFDNTVAIHPT SEE VT+R Sbjct: 408 HGIGIGVDEMLQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR 452 >5U1O-A nrPDB Length = 458 Score = 438 bits (1127), Expect = e-123, Method: Compositional matrix adjust. Identities = 243/461 (52%), Positives = 312/461 (67%), Gaps = 17/461 (3%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 +DY+ IGGGSGG+ASA RAA GA+ A++E+ LGGTCVNVGCVPKKVMW+ A +E M+ Sbjct: 12 FDYICIGGGSGGIASANRAAMYGAKVALIEAQDLGGTCVNVGCVPKKVMWHGAQIAEAMN 71 Query: 125 DHA-DYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 +A DYGF F+W + E R AY+ R++ Y L + + +I+G A F + T Sbjct: 72 LYAEDYGFDVDVKGFDWSKLVESRQAYIGRIHQSYDRVLGNNKVNVIKGFAKFVDEK--T 129 Query: 184 IEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIA 243 +EV+G+ YTA HILIA GG P+ P+ IPGA GI S+GFF L E P R +VGAGYIA Sbjct: 130 VEVNGEHYTADHILIAVGGRPTIPN---IPGAEYGIDSNGFFDLAEQPKRVAVVGAGYIA 186 Query: 244 VEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLS 303 VE+AG+L ALG++T L +R + LRSFD MI E +E G + S KEV K Sbjct: 187 VEIAGVLHALGTETHLFVRKESPLRSFDPMIIDTLVEVMEAEGPTLHTHSVPKEVVKEAD 246 Query: 304 G-LEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEF 362 G L + + +VD L+WAIGR P T ++L G+ T++KG+I VDE+ Sbjct: 247 GSLTLHLENGES---------QNVDQLIWAIGRHPATDAINLASTGVATNEKGYIKVDEY 297 Query: 363 QNTNVKGIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPI 421 Q TNVKGIY VGD+ G LTPVA+ AGR+L+ RLF K ++K+DY+ +PTVVFSHPPI Sbjct: 298 QETNVKGIYCVGDIMEGGIELTPVAVKAGRQLSERLFNNKPNAKMDYDLVPTVVFSHPPI 357 Query: 422 GTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQG 481 GT+GLT EA KYG +N+K Y++ FT MY AVTK + C MK+VCA +EE VVG+H G Sbjct: 358 GTIGLTTQEAEEKYGKDNIKVYTSGFTAMYTAVTKHRQPCKMKLVCAGEEETVVGLHGIG 417 Query: 482 LGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 522 DEM+QGF VA+KMGATKADFD+ VAIHPT SEE VT+R Sbjct: 418 FTVDEMIQGFGVAMKMGATKADFDSVVAIHPTGSEEFVTMR 458 >2HQM-A nrPDB Length = 479 Score = 430 bits (1105), Expect = e-121, Method: Compositional matrix adjust. Identities = 238/471 (50%), Positives = 306/471 (64%), Gaps = 24/471 (5%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 YDYLVIGGGSGG+ASARRAA GA+ +VE+ LGGTCVNVGCVPKKVMW + + + Sbjct: 12 YDYLVIGGGSGGVASARRAASYGAKTLLVEAKALGGTCVNVGCVPKKVMWYASDLATRVS 71 Query: 125 DHADYGFPSC------EGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTS 178 +YG FNW K+KRDAYV RLN IYQ NL K ++++ G A F Sbjct: 72 HANEYGLYQNLPLDKEHLTFNWPEFKQKRDAYVHRLNGIYQKNLEKEKVDVVFGWARFNK 131 Query: 179 DPKPTIEVSGKK-----YTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGR 233 D +EV + Y+A HIL+ATGG P IPG LG SDGFF+LEE P + Sbjct: 132 DG--NVEVQKRDNTTEVYSANHILVATGGKAIFP--ENIPGFELGTDSDGFFRLEEQPKK 187 Query: 234 SVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFS 293 V+VGAGYI +E+AG+ LGS+T L+IR + VLR FD I T+ G+ V K S Sbjct: 188 VVVVGAGYIGIELAGVFHGLGSETHLVIRGETVLRKFDECIQNTITDHYVKEGINVHKLS 247 Query: 294 QVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDD 353 ++ +V+K + ++ + + I DVD L+W IGR + S N +GI+ + Sbjct: 248 KIVKVEKNVETDKLKI------HMNDSKSIDDVDELIWTIGRKSHLGMGSEN-VGIKLNS 300 Query: 354 KGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLF--EYKEDSKLDYNNI 411 II DE+QNTNV IY++GDV GK LTPVAIAAGRKL++RLF E + KLDY N+ Sbjct: 301 HDQIIADEYQNTNVPNIYSLGDVVGKVELTPVAIAAGRKLSNRLFGPEKFRNDKLDYENV 360 Query: 412 PTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKE 471 P+V+FSHP G++G++E EAI KYG EN+K Y++ FT MY+A+ K+ K+VCA Sbjct: 361 PSVIFSHPEAGSIGISEKEAIEKYGKENIKVYNSKFTAMYYAMLSEKSPTRYKIVCAGPN 420 Query: 472 EKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 522 EKVVG+H+ G E+LQGF VA+KMGATKADFDN VAIHPTS+EELVT+R Sbjct: 421 EKVVGLHIVGDSSAEILQGFGVAIKMGATKADFDNCVAIHPTSAEELVTMR 471 >6DU7-A nrPDB Length = 448 Score = 421 bits (1083), Expect = e-118, Method: Compositional matrix adjust. Identities = 216/442 (48%), Positives = 285/442 (64%), Gaps = 15/442 (3%) Query: 82 RAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHA-DYGFPSCEGKFNW 140 RA E GA+AAV+E KLGGTCVNVGCVPKK+MW A +E H DYGF + + F++ Sbjct: 21 RAGEHGAQAAVIEEKKLGGTCVNVGCVPKKIMWYGAQIAETFHQFGEDYGFKTTDLNFDF 80 Query: 141 RVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIAT 200 ++ R++Y+ R + Y + ++ +++I GHA F T+ V+G+ A HI+IAT Sbjct: 81 ATLRRNRESYIDRARSSYDGSFKRNGVDLIEGHAEFVD--SHTVSVNGELIRAKHIVIAT 138 Query: 201 GGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLM 260 G PS P+ IPGA LG +SD F EELP I+GAGYIAVE+AG+L G KT L Sbjct: 139 GAHPSIPN---IPGAELGGSSDDVFAWEELPESVAILGAGYIAVELAGVLHTFGVKTDLF 195 Query: 261 IRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVM 320 +R D+ LR FDS I +E+E + + +++KT G+ + Sbjct: 196 VRRDRPLRGFDSYIVEGLVKEMERTNLPLHTHKVPVKLEKTTDGITIHFEDGTS------ 249 Query: 321 TMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKA 380 ++WA GR PN K L L K G+ +++G I VDE+QNT V+GIYA+GDV G+ Sbjct: 250 ---HTASQVIWATGRRPNVKGLQLEKAGVTLNERGFIQVDEYQNTVVEGIYALGDVTGEK 306 Query: 381 LLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENV 440 LTPVAI AGR L+ RLF K +K+DY+ IPTVVFSHP IGTVGLTE++AI +YG + + Sbjct: 307 ELTPVAIKAGRTLSERLFNGKTTAKMDYSTIPTVVFSHPAIGTVGLTEEQAIKEYGQDQI 366 Query: 441 KTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGAT 500 K Y +SF MY A T+ + + K++ A EEKVVG+H G G DEM+QGFAVA+KMGAT Sbjct: 367 KVYKSSFASMYSACTRNRQESRFKLITAGSEEKVVGLHGIGYGVDEMIQGFAVAIKMGAT 426 Query: 501 KADFDNTVAIHPTSSEELVTLR 522 KADFD TVAIHPTSSEE VT+R Sbjct: 427 KADFDATVAIHPTSSEEFVTMR 448 >1ONF-A nrPDB Length = 500 Score = 327 bits (838), Expect = 8e-90, Method: Compositional matrix adjust. Identities = 204/508 (40%), Positives = 299/508 (58%), Gaps = 64/508 (12%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 YD +VIGGGSGG+A+ARRAA A+ A+VE +LGGTCVNVGCVPKK+M+N A + + Sbjct: 3 YDLIVIGGGSGGMAAARRAARHNAKVALVEKSRLGGTCVNVGCVPKKIMFNAASVHDILE 62 Query: 125 DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTI 184 + YGF + + FN ++ E+RD Y+ RLN IY+ NL+K +++ G A+F S+ + I Sbjct: 63 NSRHYGFDT-KFSFNLPLLVERRDKYIQRLNNIYRQNLSKDKVDLYEGTASFLSENRILI 121 Query: 185 E---VSGKKYTAP---------HILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPG 232 + + K P +ILIA G P P + G I+SD FF ++E Sbjct: 122 KGTKDNNNKDNGPLNEEILEGRNILIAVGNKPVFP---PVKGIENTISSDEFFNIKE-SK 177 Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF 292 + IVG+GYIAVE+ ++ LG + + R +++LR FD + +++ + ++ F Sbjct: 178 KIGIVGSGYIAVELINVIKRLGIDSYIFARGNRILRKFDESVINVLENDMKKNNINIVTF 237 Query: 293 SQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD 352 + V E+KK +S +S+ + GR+ D +++ +GR P+T++L L KL ++T+ Sbjct: 238 ADVVEIKK-VSDKNLSIHLS-DGRI-----YEHFDHVIYCVGRSPDTENLKLEKLNVETN 290 Query: 353 DKGHIIVDEFQNTNVKGIYAVGDVC----------------------------------G 378 + +I+VDE Q T+V IYAVGD C Sbjct: 291 N-NYIVVDENQRTSVNNIYAVGDCCMVKKSKEIEDLNLLKLYNEERYLNKKENVTEDIFY 349 Query: 379 KALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIE 438 LTPVAI AGR LA RLF K+ K +Y IPTV+FSHPPIGT+GL+E+ AI YG E Sbjct: 350 NVQLTPVAINAGRLLADRLF-LKKTRKTNYKLIPTVIFSHPPIGTIGLSEEAAIQIYGKE 408 Query: 439 NVKTYSTSFTPMYHAVT----KRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVA 494 NVK Y + FT ++ +V + K K +K+VC K+E + G+H+ GL DE++QGFAVA Sbjct: 409 NVKIYESKFTNLFFSVYDIEPELKEKTYLKLVCVGKDELIKGLHIIGLNADEIVQGFAVA 468 Query: 495 VKMGATKADFDNTVAIHPTSSEELVTLR 522 +KM ATK DFD T+ IHPT++EE +TL+ Sbjct: 469 LKMNATKKDFDETIPIHPTAAEEFLTLQ 496 >1ZDL-A nrPDB Length = 517 Score = 315 bits (807), Expect = 3e-86, Method: Compositional matrix adjust. Identities = 199/484 (41%), Positives = 279/484 (57%), Gaps = 27/484 (5%) Query: 58 AAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVE---------SHKLGGTCVNVGCV 108 AAG S+D LVIGGGSGGLA A+ AA+LG + AV + LGGTCVNVGC+ Sbjct: 26 AAGGQQSFDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCI 85 Query: 109 PKKVMWNTAVHSEFMHDHADYGFPSCEG-KFNWRVIKEKRDAYVSRLNAIYQNNLTKSHI 167 PKK+M A+ + D YG+ + + NW+ + E +V LN ++ L + Sbjct: 86 PKKLMHQAALLGGMIRDAHHYGWEVAQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKV 145 Query: 168 EIIRGHAAFTSDPKPTIEVSGKKYT---APHILIATGGMPSTPHESQIPGA-SLGITSDG 223 + A+F + G K T A HI+IATGG P P +Q+ GA GITSD Sbjct: 146 KYFNIKASFVDEHTVRGVDKGGKATLLSAEHIVIATGGRPRYP--TQVKGALEYGITSDD 203 Query: 224 FFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELE 283 F L+E PG++++VGA Y+A+E AG L+ +G T++M+R LR FD +S+ TE +E Sbjct: 204 IFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTVMMR-SIPLRGFDQQMSSLVTEHME 262 Query: 284 NAGVEVLKFSQVKEVKKT-LSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDL 342 + G + LK +KK + L+V+ G+ T D +LWAIGRVP T+ L Sbjct: 263 SHGTQFLKGCVPSHIKKLPTNQLQVTWEDHASGKEDTGTF----DTVLWAIGRVPETRTL 318 Query: 343 SLNKLGIQTDDKGH-IIVDEFQNTNVKGIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEY 400 +L K GI T+ K IIVD + T+V IYA+GDV G+ LTP AI AG+ LA RLF Sbjct: 319 NLEKAGISTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFG- 377 Query: 401 KEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRK-T 459 K + +DY+N+PT VF+ G VGL+E+EA+ +G E+V+ Y + P+ V R + Sbjct: 378 KSSTLMDYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRDAS 437 Query: 460 KCVMKMVCANKEEK-VVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 +C +KMVC + + V+G+H G E+ QGFA+ +K GA+ A TV IHPT SEE+ Sbjct: 438 QCYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEV 497 Query: 519 VTLR 522 V L Sbjct: 498 VKLH 501 >3O0H-A nrPDB Length = 484 Score = 304 bits (779), Expect = 5e-83, Method: Compositional matrix adjust. Identities = 179/475 (37%), Positives = 264/475 (55%), Gaps = 20/475 (4%) Query: 49 EPQPQGPPPAAGAVASYDY--LVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVG 106 E Q QGP G++ S+D+ VIG GSGG+ +AR A LG R A+ E +++GGTCV G Sbjct: 13 EAQTQGP----GSMGSFDFDLFVIGSGSGGVRAARLAGALGKRVAIAEEYRIGGTCVIRG 68 Query: 107 CVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSH 166 CVPKK+ + + +++ +G+ + FNW + ++ +SRL +Y+ L S+ Sbjct: 69 CVPKKLYFYASQYAQEFSKSIGFGWKYADPIFNWEKLVAAKNKEISRLEGLYREGLQNSN 128 Query: 167 IEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQ 226 + I A F + + V+G++ +A ILIATG S I G+ L +TS+ F Sbjct: 129 VHIYESRAVFVDEHTLELSVTGERISAEKILIATG--AKIVSNSAIKGSDLCLTSNEIFD 186 Query: 227 LEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAG 286 LE+LP VIVG GYI VE A I LG KT+L+ R D +LR+FD + + + G Sbjct: 187 LEKLPKSIVIVGGGYIGVEFANIFHGLGVKTTLLHRGDLILRNFDYDLRQLLNDAMVAKG 246 Query: 287 VEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNK 346 + ++ + V +V+ T + V + T+ D ++ A GRVPNT L L + Sbjct: 247 ISIIYEATVSQVQSTENCYNVVLTNG-------QTICA--DRVMLATGRVPNTTGLGLER 297 Query: 347 LGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKL 406 G++ ++ G ++VDE TNV I+AVGDV G LTPVAI FE + Sbjct: 298 AGVKVNEFGAVVVDEKMTTNVSHIWAVGDVTGHIQLTPVAIHDAMCFVKNAFE-NTSTTP 356 Query: 407 DYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMV 466 DY+ I T VFS P IGTVGL+E++A+H+Y + V+ Y T F PM + ++ K MK+V Sbjct: 357 DYDLITTAVFSQPEIGTVGLSEEDALHRY--KRVEIYRTVFRPMRNVLSGSPEKMFMKLV 414 Query: 467 CANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTL 521 + VVG H+ G E+ Q +++K TK FD T+A+HPT SEELVT+ Sbjct: 415 VDGESRIVVGAHVLGENAGEIAQLIGISLKGKLTKDIFDKTMAVHPTMSEELVTM 469 >4DNA-A nrPDB Length = 463 Score = 289 bits (740), Expect = 2e-78, Method: Compositional matrix adjust. Identities = 180/459 (39%), Positives = 255/459 (55%), Gaps = 15/459 (3%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFM 123 YD VIGGGSGG+ S R AA LG + A+ E + GGTCV GCVPKK+ + +E Sbjct: 5 DYDLFVIGGGSGGVRSGRLAAALGKKVAIAEEFRYGGTCVIRGCVPKKLYVYASQFAEHF 64 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 D A +G+ E +F+W + ++ ++RL +Y+ L + EI+ A Sbjct: 65 EDAAGFGWTVGESRFDWAKLVAAKEQEIARLEGLYRKGLANAGAEILDTRAELAGPNTVK 124 Query: 184 IEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIA 243 + SGK TA I+IA GG PS PH++ +PG L ITS+ F L LP +I G GYIA Sbjct: 125 LLASGKTVTAERIVIAVGGHPS-PHDA-LPGHELCITSNEAFDLPALPESILIAGGGYIA 182 Query: 244 VEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLS 303 VE A I LG KT+L+ R ++L FD + +E G+ +L ++ V Sbjct: 183 VEFANIFHGLGVKTTLIYRGKEILSRFDQDMRRGLHAAMEEKGIRILCEDIIQSVSADAD 242 Query: 304 GLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQ 363 G V+ T G + D ++ A+GR+PNT L L G++T++ G IIVD F Sbjct: 243 GRRVA-TTMKHGEIV-------ADQVMLALGRMPNTNGLGLEAAGVRTNELGAIIVDAFS 294 Query: 364 NTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKED-SKLDYNNIPTVVFSHPPIG 422 T+ GIYA+GDV + LTPVAI EYK + + D++ I T VFS P IG Sbjct: 295 RTSTPGIYALGDVTDRVQLTPVAIHEAMCFIET--EYKNNPTSPDHDLIATAVFSQPEIG 352 Query: 423 TVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGL 482 TVG+TE+EA K+ + ++ Y F PM ++ RK K +MK+V + KVVG H+ G Sbjct: 353 TVGITEEEAARKF--QEIEVYRAEFRPMKATLSGRKEKTIMKLVVNAADRKVVGAHILGH 410 Query: 483 GCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTL 521 EM Q ++++ G TK DFD T+A+HPT++EELVT+ Sbjct: 411 DAGEMAQLLGISLRAGCTKDDFDRTMAVHPTAAEELVTM 449 >2WOV-A nrPDB Length = 495 Score = 283 bits (724), Expect = 1e-76, Method: Compositional matrix adjust. Identities = 181/486 (37%), Positives = 265/486 (54%), Gaps = 44/486 (9%) Query: 64 SYDYLVIGGGSGGLASARRAAEL-GARAAVVE---SH------KLGGTCVNVGCVPKKVM 113 ++D +VIG GSGGL + AA L G R AVV+ SH LGGTCVNVGCVPKK+M Sbjct: 7 AFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLM 66 Query: 114 WNTAVHSEFMHDHADYG--FPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSH-IEII 170 A + + + + A +G F K NW+ + ++ V +N Y+ + ++ Sbjct: 67 VTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFF 126 Query: 171 RGHAAF----------TSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGIT 220 G + T+DPK ++ ++ A HIL+ATG P P IPG I+ Sbjct: 127 LGWGSLESKNVVVVRETADPKSAVK---ERLQADHILLATGSWPQMP---AIPGIEHCIS 180 Query: 221 SDGFFQLEELPGRSVIVGAGYIAVEMAGILSAL---GSKTSLMIRHDKVLRSFDSMISTN 277 S+ F L E P R + VG G+I+VE AGI +A G K +L R++ +LR FD I Sbjct: 181 SNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETIREE 240 Query: 278 CTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVP 337 T++L G+E++ +V G + VT G+ DVD ++ AIGR+P Sbjct: 241 VTKQLTANGIEIMTNENPAKVSLNTDGSK--HVTFESGK------TLDVDVVMMAIGRIP 292 Query: 338 NTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRL 397 T DL L +G++ KG + VDEF TNV IYA+GD+ + +LTPVAI G L + Sbjct: 293 RTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTV 352 Query: 398 FEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKR 457 F K K D+ + + VFS PPIGT GL E+ A ++ E V Y +SFTP+ H ++ Sbjct: 353 FGNKP-RKTDHTRVASAVFSIPPIGTCGLIEEVAAKEF--EKVAVYMSSFTPLMHNISGS 409 Query: 458 K-TKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSE 516 K K V K+V + + V+G+H+ G G E++Q V +++ A +DF NT+ +HPTS+E Sbjct: 410 KYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAE 469 Query: 517 ELVTLR 522 EL ++R Sbjct: 470 ELCSMR 475 >2X8H-A nrPDB Length = 598 Score = 275 bits (704), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 178/483 (36%), Positives = 266/483 (55%), Gaps = 33/483 (6%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVE---------SHKLGGTCVNVGCVPKKVMW 114 YD +VIGGGSGGLA+ + AA+ GA+ AV++ + LGGTCVNVGC+PKK+M Sbjct: 107 DYDLIVIGGGSGGLAAGKEAAKYGAKTAVLDYVEPTPIGTTWGLGGTCVNVGCIPKKLMH 166 Query: 115 NTAVHSEFMHDHADYGFPSCEGKF--NWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRG 172 + S + D +G+ K NW + E +++ LN Y+ L + + + Sbjct: 167 QAGLLSHALEDAEHFGWSLDRSKISHNWSTMVEGVQSHIGSLNWGYKVALRDNQVTYLNA 226 Query: 173 HAAFTSDPKPTIEVSGKKY---TAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQLE 228 S + I +K T I++ATG P P +IPGA GITSD F L Sbjct: 227 KGRLISPHEVQITDKNQKVSTITGNKIILATGERPKYP---EIPGAVEYGITSDDLFSLP 283 Query: 229 ELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVE 288 PG+++++GA Y+A+E AG L++LG ++M+R +LR FD ++ + +EN GV+ Sbjct: 284 YFPGKTLVIGASYVALECAGFLASLGGDVTVMVR-SILLRGFDQQMAEKVGDYMENHGVK 342 Query: 289 VLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPD-------VDCLLWAIGRVPNTKD 341 K E+K+ V PG L V D + +++A+GR P Sbjct: 343 FAKLCVPDEIKQLKV---VDTENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSK 399 Query: 342 LSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDV-CGKALLTPVAIAAGRKLAHRLFEY 400 + +G++ D G ++ + + T V +YA+GD+ GK LTPVAI AGR LA RLF Sbjct: 400 VLCETVGVKLDKNGRVVCTDDEQTTVSNVYAIGDINAGKPQLTPVAIQAGRYLARRLFAG 459 Query: 401 KEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTK 460 + DY+N+ T VF+ G GL+E++AI KYG ++++ Y ++F P+ V R+ Sbjct: 460 ATELT-DYSNVATTVFTPLEYGACGLSEEDAIEKYGDKDIEVYHSNFKPLEWTVAHREDN 518 Query: 461 -CVMKMVCANKEE-KVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 C MK+VC + +V+G+H+ G E+ QG+AVA+KMGATKADFD T+ IHPT SE Sbjct: 519 VCYMKLVCRKSDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKADFDRTIGIHPTCSETF 578 Query: 519 VTL 521 TL Sbjct: 579 TTL 581 >4LA1-A nrPDB Length = 602 Score = 266 bits (680), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 166/467 (35%), Positives = 249/467 (53%), Gaps = 33/467 (7%) Query: 81 RRAAELGARAAVVE---------SHKLGGTCVNVGCVPKKVMWNTAVHSEFMHD--HADY 129 + AA+ GA+ AV++ + LGGTCVNVGC+PKK+M + S + D H + Sbjct: 130 KEAAKYGAKIAVLDYVEPTPMGTTWGLGGTCVNVGCIPKKLMHQAGLLSHSLEDAQHFGW 189 Query: 130 GFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGK 189 E +W + E +++ LN Y+ +L + + + S + I K Sbjct: 190 SLDKSEISHDWSTMVEGVQSHIGSLNWGYKVSLRDNAVTYLNARGMLLSPHEVQITEKNK 249 Query: 190 KY---TAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQLEELPGRSVIVGAGYIAVE 245 K T I++ATG P P +IPGA GITSD F L PG++++VGA Y+A++ Sbjct: 250 KVSTITGNKIILATGERPKYP---EIPGAIEYGITSDDLFSLPYFPGKTLVVGASYVALK 306 Query: 246 MAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGL 305 AG L++LG ++M+R +LR FD ++ + +EN GV+ K E+ + Sbjct: 307 CAGFLASLGGDVTVMVR-SILLRGFDQQMAEKVGDYMENHGVKFAKLCVPDEITQLKP-- 363 Query: 306 EVSMVTAVPGRLPVMTMIPD-------VDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHII 358 V PG L V D + +++A+GR P L+ +G++ D G ++ Sbjct: 364 -VDTENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSKLNCEAVGVKLDKNGRVV 422 Query: 359 VDEFQNTNVKGIYAVGDV-CGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFS 417 + + T V IYA+GD+ GK LTPVAI AGR LA RLF + DY+N+ T VF+ Sbjct: 423 CSDDEQTTVSNIYAIGDINAGKPQLTPVAIHAGRYLARRLFAGATELT-DYSNVATTVFT 481 Query: 418 HPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTK-CVMKMVCANKEE-KVV 475 G GL+E++AI KYG +++ Y + F P+ V R+ C MK+VC + +V+ Sbjct: 482 PLEYGACGLSEEDAIEKYGDNDIEVYHSHFKPLEWTVAHREDNVCYMKLVCRISDNMRVL 541 Query: 476 GIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 522 G+H+ G E+ QG+AVA+KMGATK DFD T+ IHPT SE TL Sbjct: 542 GLHVLGPNAGEITQGYAVAIKMGATKEDFDRTIGIHPTCSETFTTLH 588 >1FEC-A nrPDB Length = 490 Score = 263 bits (673), Expect = 1e-70, Method: Compositional matrix adjust. Identities = 170/483 (35%), Positives = 250/483 (51%), Gaps = 38/483 (7%) Query: 64 SYDYLVIGGGSGGLASARRAAEL-GARAAVVESHK---------LGGTCVNVGCVPKKVM 113 +YD +VIG GSGGL + AA L R AV++ K LGGTCVNVGCVPKK+M Sbjct: 3 AYDLVVIGAGSGGLEAGWNAASLHKKRVAVIDLQKHHGPPHYAALGGTCVNVGCVPKKLM 62 Query: 114 WNTAVHSEFMHDHADYGFPSCEGKF--NWRVIKEKRDAYVSRLNAIYQNNLTKSH-IEII 170 A + + + + A +G+ NW+ + ++ VS +N Y+ + + Sbjct: 63 VTGANYMDTIRESAGFGWELDRESVRPNWKALIAAKNKAVSGINDSYEGMFADTEGLTFH 122 Query: 171 RGHAAFTSDPKPTIEVSGKKYTA-------PHILIATGGMPSTPHESQIPGASLGITSDG 223 +G A + + S +A +IL+ATG S P I G L ITS+ Sbjct: 123 QGFGALQDNHTVLVRESADPNSAVLETLDTEYILLATG---SWPQHLGIEGDDLCITSNE 179 Query: 224 FFQLEELPGRSVIVGAGYIAVEMAGILSAL---GSKTSLMIRHDKVLRSFDSMISTNCTE 280 F L+E P R++ VG GYI++E AGI +A G + L R D +LR FDS + TE Sbjct: 180 AFYLDEAPKRALCVGGGYISIEFAGIFNAYKARGGQVDLAYRGDMILRGFDSELRKQLTE 239 Query: 281 ELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTK 340 +L G+ V +V K G + + D D ++ AIGRVP ++ Sbjct: 240 QLRANGINVRTHENPAKVTKNADGTRHVVFES--------GAEADYDVVMLAIGRVPRSQ 291 Query: 341 DLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEY 400 L L K G++ G I VD + TNV IYA+GDV + +LTPVAI G +F Sbjct: 292 TLQLEKAGVEVAKNGAIKVDAYSKTNVDNIYAIGDVTDRVMLTPVAINEGAAFVDTVFAN 351 Query: 401 KEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTK 460 K + D+ + VFS PP+G G E++A KY + V Y +SFTP+ H ++ K Sbjct: 352 KPRAT-DHTKVACAVFSIPPMGVCGYVEEDAAKKY--DQVAVYESSFTPLMHNISGSTYK 408 Query: 461 CVM-KMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELV 519 M ++V + + +V+G+HM G E++Q A+ +KMGA +DF NT+ +HPTS+EEL Sbjct: 409 KFMVRIVTNHADGEVLGVHMLGDSSPEIIQSVAICLKMGAKISDFYNTIGVHPTSAEELC 468 Query: 520 TLR 522 ++R Sbjct: 469 SMR 471 >5W1J-A nrPDB Length = 584 Score = 262 bits (669), Expect = 3e-70, Method: Compositional matrix adjust. Identities = 169/483 (34%), Positives = 276/483 (57%), Gaps = 34/483 (7%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVE---------SHKLGGTCVNVGCVPKKVMW 114 YD ++IGGGSGGLA A+ +A+ GA+ A+++ + LGGTCVNVGC+PKK+M Sbjct: 103 DYDMVIIGGGSGGLALAKESAKSGAKVALLDFVVPTPMGTTWGLGGTCVNVGCIPKKLMH 162 Query: 115 NTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHI------- 167 A+ + +M D +G+ +G +W + E ++ LN Y++++ +++ Sbjct: 163 QAALLNHYMEDAKSFGWDVDKGPHDWVKMVEGIQDHIHALNFGYRSSMMNANVKYLNALG 222 Query: 168 EIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQ 226 EI+ H T++ + + K T I++ATG P P IPGA GITSD F Sbjct: 223 EIVDPHTIKTTNKQGIV----KNITTNTIIVATGERPRYP---PIPGAKEYGITSDDLFT 275 Query: 227 LEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAG 286 L+ PG+++ VGA Y+++E AG LS++G ++M+R LR FD ++ ++ + G Sbjct: 276 LDHNPGKTLCVGASYVSLECAGFLSSIGCDVTVMVR-SIFLRGFDQQMAGLISDYIAKYG 334 Query: 287 VEVLKF---SQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDV-DCLLWAIGRVPNTKDL 342 V+ ++ + V+ +++ + V G+ T D + +L+A+GR P T ++ Sbjct: 335 VKFVRPCVPTSVRCLEEYDPESGKLAIYEVEGKHEDGTPFKDTFNTVLFAVGRDPCTTNI 394 Query: 343 SLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKAL-LTPVAIAAGRKLAHRLFEYK 401 L + ++T + G ++VD+ + TNV IYA+GDV LTP+AI AG+ LA RL+ Sbjct: 395 GLQNVDVKTTN-GRVVVDDEERTNVPNIYAIGDVSNAGYQLTPLAIQAGKNLARRLYT-A 452 Query: 402 EDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKR-KTK 460 +D + DY N+PT VF+ G +GL+E+ AI K+G +N++ + + F P+ V R Sbjct: 453 DDCRTDYTNVPTTVFTPLEYGCIGLSEENAISKFGEDNIEVFHSYFQPLEWTVPHRPDNT 512 Query: 461 CVMKMVCANKEE-KVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELV 519 C K++ +++ +VVG H+ G E+ QG+AVA+ +GA K DFD T+ IHPT SE Sbjct: 513 CYAKLIINKQDDNRVVGFHVFGPNAGEVTQGYAVAMHLGARKEDFDRTIGIHPTCSETFT 572 Query: 520 TLR 522 TLR Sbjct: 573 TLR 575 >4NEW-A nrPDB Length = 492 Score = 258 bits (658), Expect = 6e-69, Method: Compositional matrix adjust. Identities = 173/485 (35%), Positives = 252/485 (51%), Gaps = 45/485 (9%) Query: 65 YDYLVIGGGSGGLASARRAAEL-GARAAVVESH---------KLGGTCVNVGCVPKKVMW 114 +D +VIG GSGGL +A AA L R AV++ LGGTCVNVGCVPKK+M Sbjct: 6 FDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVGCVPKKLMV 65 Query: 115 NTAVHSEFMHDHADYG--FPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSH-IEIIR 171 A + E + + A +G F + W+ + +D V +N Y + +E Sbjct: 66 TGAQYMEHLRESAGFGWEFDRTTLRAEWKNLIAVKDEAVLNINKSYDEMFRDTEGLEFFL 125 Query: 172 GHAAFTS----------DPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITS 221 G + S DP ++ ++ HIL+A+G S PH IPG I+S Sbjct: 126 GWGSLESKNVVNVRESADPASAVK---ERLETEHILLASG---SWPHMPNIPGIEHCISS 179 Query: 222 DGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSK---TSLMIRHDKVLRSFDSMISTNC 278 + F L E P R + VG G+I+VE AGI +A K +L R + +LR FD + Sbjct: 180 NEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREEL 239 Query: 279 TEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPN 338 T++L G+++L +V+ G + VT G+ D D ++ AIGR P Sbjct: 240 TKQLTANGIQILTKENPAKVELNADGSK--SVTFESGKKM------DFDLVMMAIGRSPR 291 Query: 339 TKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLF 398 TKDL L G+ + G + VDE+ TNV IYA+GDV + +LTPVAI L +F Sbjct: 292 TKDLQLQNAGVMIKNGG-VQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTVF 350 Query: 399 EYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRK 458 K D+ + + VFS PPIGT GL E+ A +Y E V Y +SFTP+ H V+ K Sbjct: 351 G-TTPRKTDHTRVASAVFSIPPIGTCGLIEEVASKRY--EVVAVYLSSFTPLMHKVSGSK 407 Query: 459 TKC-VMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEE 517 K V K++ + + V+G+H+ G E++QG + +K+ A +DF NT+ +HPTS+EE Sbjct: 408 YKTFVAKIITNHSDGTVLGVHLLGDNAPEIIQGIGICLKLNAKISDFYNTIGVHPTSAEE 467 Query: 518 LVTLR 522 L ++R Sbjct: 468 LCSMR 472 >2NVK-X nrPDB Length = 488 Score = 255 bits (651), Expect = 3e-68, Method: Compositional matrix adjust. Identities = 174/477 (36%), Positives = 258/477 (54%), Gaps = 30/477 (6%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHK----------LGGTCVNVGCVPKKVM 113 YD +VIGGGS GLA A+ A GAR A ++ K +GGTCVNVGC+PKK+M Sbjct: 9 DYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKKLM 68 Query: 114 WNTAVHSEFMHDHADYGFPSCEG-KFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRG 172 ++ E +H+ A YG+ + K +W + + ++ +N + + +L +E I G Sbjct: 69 HQASLLGEAVHEAAAYGWNVDDKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYING 128 Query: 173 HAAFTSDPKPTIEV-SGKK-YTAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQLEE 229 +F ++ SG++ TA +IA GG P P IPGA GITSD F L+ Sbjct: 129 LGSFVDSHTLLAKLKSGERTITAQTFVIAVGGRPRYP---DIPGAVEYGITSDDLFSLDR 185 Query: 230 LPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEV 289 PG++++VGAGYI +E AG L LG + ++M+R VLR FD ++ +E G+ Sbjct: 186 EPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVR-SIVLRGFDQQMAELVAASMEERGIPF 244 Query: 290 LKFSQVKEVKKTLSG-LEVSMVTAVPGRLPVMTMIPDV-DCLLWAIGRVPNTKDLSLNKL 347 L+ + V+K G L V G DV D +LWAIGR DL+L Sbjct: 245 LRKTVPLSVEKQDDGKLLVKYKNVETGEES-----EDVYDTVLWAIGRKGLVDDLNLPNA 299 Query: 348 GIQTDDKGHIIVDEFQNTNVKGIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKL 406 G+ T K I VD + TNV IYAVGD+ GK LTPVA+ AGR LA RL+ ++ Sbjct: 300 GV-TVQKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYG-GSTQRM 357 Query: 407 DYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTK-CVMKM 465 DY ++ T VF+ VGL+E++A+ ++G + ++ + + P + ++ + C +K Sbjct: 358 DYKDVATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKA 417 Query: 466 VCA-NKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTL 521 V + +++V G+H G E++QGFA A+K G T NTV IHPT++EE L Sbjct: 418 VAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRL 474 >2YAU-A nrPDB Length = 511 Score = 253 bits (646), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 169/490 (34%), Positives = 251/490 (51%), Gaps = 52/490 (10%) Query: 64 SYDYLVIGGGSGGLASARRAA-ELGARAAVVESHK---------LGGTCVNVGCVPKKVM 113 +YD +V+G GSGGL + AA + AVV+ LGGTCVNVGCVPKK+M Sbjct: 24 AYDLVVLGAGSGGLEAGWNAAVTHKKKVAVVDVQATHGPPLFAALGGTCVNVGCVPKKLM 83 Query: 114 WNTAVHSEFMHDHADYGFPSCEGKF--NWRVIKEKRDAYVSRLNAIYQN----------- 160 A + + + + +G+ NW+ + ++ V+ +N Y++ Sbjct: 84 VTGAQYMDLIRESGGFGWEMDRESLCPNWKTLIAAKNKVVNSINESYKSMFADTEGLSFH 143 Query: 161 ----NLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGAS 216 L +H ++R SD T++ +ILIATG S P +PG Sbjct: 144 MGFGALQDAHTVVVRKSEDPHSDVLETLDTE-------YILIATG---SWPTRLGVPGDE 193 Query: 217 LGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSAL---GSKTSLMIRHDKVLRSFDSM 273 ITS+ F LE+ P R + VG GYIAVE AGI + G L R D +LR FD+ Sbjct: 194 FCITSNEAFYLEDAPKRMLCVGGGYIAVEFAGIFNGYKPCGGYVDLCYRGDLILRGFDTE 253 Query: 274 ISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAI 333 + + T++L G+ V ++ K G + V G D D ++ AI Sbjct: 254 VRKSLTKQLGANGIRVRTNLNPTKITKNEDG--SNHVHFNDGTEE------DYDQVMLAI 305 Query: 334 GRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKL 393 GRVP ++ L L+K G++T G + VD + T+V IYA+GDV + +LTPVAI G Sbjct: 306 GRVPRSQALQLDKAGVRTGKNGAVQVDAYSKTSVDNIYAIGDVTNRVMLTPVAINEGAAF 365 Query: 394 AHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHA 453 +F K + D+ + VFS PPIGT G+TE+EA Y E V Y++SFTP+ H Sbjct: 366 VETVFGGKPRAT-DHTKVACAVFSIPPIGTCGMTEEEAAKNY--ETVAVYASSFTPLMHN 422 Query: 454 VTKRKTKCVMKMVCANKEE-KVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHP 512 ++ K K M + N+ +V+G+HM G E++Q + +KMGA +DF +T+ +HP Sbjct: 423 ISGSKHKEFMIRIITNESNGEVLGVHMLGDSAPEIIQSVGICMKMGAKISDFHSTIGVHP 482 Query: 513 TSSEELVTLR 522 TS+EEL ++R Sbjct: 483 TSAEELCSMR 492 >4KPR-E nrPDB Length = 499 Score = 244 bits (622), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 157/442 (35%), Positives = 240/442 (54%), Gaps = 32/442 (7%) Query: 98 LGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEG-KFNWRVIKEKRDAYVSRLNA 156 LGGTCVNVGC+PKK+M A+ + + D +YG+ + K +W + E ++ LN Sbjct: 55 LGGTCVNVGCIPKKLMHQAALLGQALKDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNW 114 Query: 157 IYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKK----YTAPHILIATGGMPSTPHESQI 212 Y+ L + + + F P + + K Y+A LIATG P I Sbjct: 115 GYRVALREKKVVYENAYGKFIG-PHKIMATNNKGKEKVYSAERFLIATG---ERPRYLGI 170 Query: 213 PG-ASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFD 271 PG I+SD F L PG++++VGA Y+A+E AG L+ +G ++M+R +LR FD Sbjct: 171 PGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVR-SILLRGFD 229 Query: 272 SMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVM--------TMI 323 ++ E +E G++ ++ ++++ +G PGRL V T+ Sbjct: 230 QDMANKIGEHMEEHGIKFIRQFVPTKIEQIEAG--------TPGRLKVTAKSTNSEETIE 281 Query: 324 PDVDCLLWAIGRVPNTKDLSLNKLGIQTDDK-GHIIVDEFQNTNVKGIYAVGDVC-GKAL 381 + + +L A+GR T+ + L +G++ ++K G I V + + TNV IYA+GD+ GK Sbjct: 282 DEFNTVLLAVGRDSCTRTIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLE 341 Query: 382 LTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVK 441 LTPVAI AGR LA RL+ K DY+N+PT VF+ G GL+E++A+ K+G EN++ Sbjct: 342 LTPVAIQAGRLLAQRLYG-GSTVKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIE 400 Query: 442 TYSTSFTPMYHAVTKR-KTKCVMKMVCANKE-EKVVGIHMQGLGCDEMLQGFAVAVKMGA 499 Y + F P+ V R KC K++C K+ E+VVG H+ G E+ QGFA A+K G Sbjct: 401 VYHSFFWPLEWTVPSRDNNKCYAKVICNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGL 460 Query: 500 TKADFDNTVAIHPTSSEELVTL 521 TK D+T+ IHP +E TL Sbjct: 461 TKQQLDSTIGIHPVCAEIFTTL 482 >4B1B-A nrPDB Length = 542 Score = 241 bits (616), Expect = 5e-64, Method: Compositional matrix adjust. Identities = 163/492 (33%), Positives = 250/492 (50%), Gaps = 47/492 (9%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHK---------LGGTCVNVGCVPKKVM- 113 YDY+VIGGG GG+ASA+ AA GAR + + K +GGTCVNVGCVPKK+M Sbjct: 42 DYDYVVIGGGPGGMASAKEAAAHGARVLLFDYVKPSSQGTKWGIGGTCVNVGCVPKKLMH 101 Query: 114 WNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGH 173 + + S F D YG+ K +W+ + +++ LN Y L S ++ I G Sbjct: 102 YAGHMGSIFKLDSKAYGWKFDNLKHDWKKLVTTVQSHIRSLNFSYMTGLRSSKVKYINGL 161 Query: 174 AAFTSDPKPTIEVSG-----KKYTAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQL 227 A + + G + T +ILIATG P P + + GA L ITSD F L Sbjct: 162 AKLKDKNTVSYYLKGDLSKEETVTGKYILIATGCRPHIPDD--VEGAKELSITSDDIFSL 219 Query: 228 EELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGV 287 ++ PG++++VGA Y+A+E +G L++LG ++ +R VLR FD + +E GV Sbjct: 220 KKDPGKTLVVGASYVALECSGFLNSLGYDVTVAVR-SIVLRGFDQQCAVKVKLYMEEQGV 278 Query: 288 EVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKL 347 + + K L+ ++ ++ + + D +L+AIGR + L+L L Sbjct: 279 ----MFKNGILPKKLTKMDDKILVEFSDKTSEL-----YDTVLYAIGRKGDIDGLNLESL 329 Query: 348 GIQTDDKGH-IIVDEFQNTNVKGIYAVGDVCGKA-LLTPVAIAAGRKLAHRLFEYKEDSK 405 + + + II D TN+ I+AVGDV L PVAI AG LA RLF+ D Sbjct: 330 NMNVNKSNNKIIADHLSCTNIPSIFAVGDVAENVPELAPVAIKAGEILARRLFK-DSDEI 388 Query: 406 LDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRK------- 458 +DY+ IPT +++ G G +E++A YG NV+ + F + + R+ Sbjct: 389 MDYSYIPTSIYTPIEYGACGYSEEKAYELYGKSNVEVFLQEFNNLEISAVHRQKHIRAQK 448 Query: 459 --------TKCVMKMVC-ANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVA 509 + C+ K+VC N++ +V+G H G E+ QG A+A+++ K DFDN + Sbjct: 449 DEYDLDVSSTCLAKLVCLKNEDNRVIGFHYVGPNAGEVTQGMALALRLKVKKKDFDNCIG 508 Query: 510 IHPTSSEELVTL 521 IHPT +E + L Sbjct: 509 IHPTDAESFMNL 520 >2CFY-A nrPDB Length = 521 Score = 241 bits (614), Expect = 7e-64, Method: Compositional matrix adjust. Identities = 160/469 (34%), Positives = 247/469 (52%), Gaps = 43/469 (9%) Query: 81 RRAAELGARAAVVE---------SHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGF 131 + AA+ G + V++ LGGTCVNVGC+PKK+M A+ + + D +YG+ Sbjct: 51 KEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGW 110 Query: 132 PSCEG-KFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKK 190 E K +W + E ++ LN Y+ L + + + F + I+ + K Sbjct: 111 KVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHR--IKATNNK 168 Query: 191 -----YTAPHILIATGGMPSTPHESQIPG-ASLGITSDGFFQLEELPGRSVIVGAGYIAV 244 Y+A LIATG P IPG I+SD F L PG++++VGA Y+A+ Sbjct: 169 GKEKIYSAERFLIATG---ERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVAL 225 Query: 245 EMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSG 304 E AG L+ +G ++M+R +LR FD ++ E +E G++ ++ +V++ +G Sbjct: 226 ECAGFLAGIGLDVTVMVR-SILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAG 284 Query: 305 LEVSMVTAVPGRLPVMTMIP--------DVDCLLWAIGRVPNTKDLSLNKLGIQTDDK-G 355 PGRL V+ + + ++ AIGR T+ + L +G++ ++K G Sbjct: 285 --------TPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTG 336 Query: 356 HIIVDEFQNTNVKGIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTV 414 I V + + TNV IYA+GD+ K LTPVAI AGR LA RL+ K DY N+PT Sbjct: 337 KIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYA-GSTVKCDYENVPTT 395 Query: 415 VFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKR-KTKCVMKMVCANKE-E 472 VF+ G GL+E++A+ K+G EN++ Y + F P+ + R KC K++C K+ E Sbjct: 396 VFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNE 455 Query: 473 KVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTL 521 +VVG H+ G E+ QGFA A+K G TK D+T+ IHP +E TL Sbjct: 456 RVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTL 504 >5X1Y-B nrPDB Length = 554 Score = 223 bits (567), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 145/457 (31%), Positives = 241/457 (52%), Gaps = 15/457 (3%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFM 123 +YD L+IG G+ +SA +A E GA+ ++E +GGTCVN+GCVP K + Sbjct: 84 NYDLLIIGSGAAAFSSAIKAIEYGAKVGMIERGTVGGTCVNIGCVPSKTLLRAGEIIHLS 143 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSRL-NAIYQNNLTKSHIEIIRGHAAFTSDPKP 182 D+ G + G+ + + ++D VS L N Y + + + + ++I+G A F Sbjct: 144 KDNPFIGLQTSAGEVDLASLITQKDKLVSELRNQKYMDLIDEYNFDLIKGEAKFVD--AS 201 Query: 183 TIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYI 242 T+EV+G K +A LIATG PS P S + +TS +L+++P R ++G+GYI Sbjct: 202 TVEVNGAKLSAKRFLIATGASPSLPQISGLEKMDY-LTSTTLLELKKIPKRLTVIGSGYI 260 Query: 243 AVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTL 302 +E+ + LGS+ +LM R +++L+ +D IS + + L G+ ++K + + V++ Sbjct: 261 GMELGQLFHHLGSEITLMQRSERLLKEYDPEISESVEKALIEQGINLVKGATFERVEQ-- 318 Query: 303 SGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEF 362 SG + V G V+ + D LL A GR PNT L+L+ G++T I++++F Sbjct: 319 SGEIKRVYVTVNGSREVI----ESDQLLVATGRKPNTDSLNLSAAGVETGKNNEILINDF 374 Query: 363 QNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIG 422 T+ + IYA GDV VA G + + K+D + +P V F++P + Sbjct: 375 GQTSNEKIYAAGDVTLGPQFVYVAAYEGGIITDNAIG-GLNKKIDLSVVPAVTFTNPTVA 433 Query: 423 TVGLTEDEAIHK-YGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQG 481 TVGLTE++A K Y +VKT + A+ R+T V K+V + KV+G+H+ Sbjct: 434 TVGLTEEQAKEKGY---DVKTSVLPLDAVPRAIVNRETTGVFKLVADAETLKVLGVHIVS 490 Query: 482 LGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 +++ ++AVK G T D T+A + T +E L Sbjct: 491 ENAGDVIYAASLAVKFGLTVEDLTETLAPYLTMAEGL 527 >5TR3-A nrPDB Length = 481 Score = 185 bits (469), Expect = 5e-47, Method: Compositional matrix adjust. Identities = 133/472 (28%), Positives = 240/472 (50%), Gaps = 36/472 (7%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHK-------LGGTCVNVGCVPKKVMWNTA 117 +D +VIG G GG +A +AA+LG + A +E + LGGTC+NVGC+P K + +++ Sbjct: 8 FDVVVIGAGPGGYVAAIKAAQLGLKTACIEKYTDAEGKLALGGTCLNVGCIPSKALLDSS 67 Query: 118 -VHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAF 176 + E +G + E K + + ++ V L + + I+GH Sbjct: 68 WKYKEAKESFNVHGISTGEVKMDVAAMVGRKAGIVKNLTGGVATLFKANGVTSIQGHGKL 127 Query: 177 TSDPKPTIEVSGKKYT-----APHILIATGG----MPSTPHESQIPGASLGITSDGFFQL 227 + K +EV+ T A ++++A+G +P P + + + S G + Sbjct: 128 LAGKK--VEVTKADGTTEVIEAENVILASGSRPIDIPPAPVDQNVI-----VDSTGALEF 180 Query: 228 EELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGV 287 + +P R ++GAG I +E+ + + LG++ +++ D L + D+ +S + L G+ Sbjct: 181 QAVPKRLGVIGAGVIGLELGSVWARLGAEVTVLEALDTFLMAADTAVSKEAQKTLTKQGL 240 Query: 288 EVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKL 347 ++ ++V K + +EV+ A G + D L+ A+GR P T DL + Sbjct: 241 DIKLGARVTGSKVNGNEVEVTYTNA-EGEQKIT-----FDKLIVAVGRRPVTTDLLASDS 294 Query: 348 GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLD 407 G+ D++G+I VD++ T+V G+YA+GDV +L A G + R+ +K ++++ Sbjct: 295 GVTIDERGYIFVDDYCATSVPGVYAIGDVVRGMMLAHKASEEGIMVVERIKGHK--AQMN 352 Query: 408 YNNIPTVVFSHPPIGTVGLTEDEAIHKYGIE-NVKTYSTSFTPMYHAVTKRKTKCVMKMV 466 Y+ IP+V+++HP I VG TE +A+ G+E NV T+ F A+ T +K++ Sbjct: 353 YDLIPSVIYTHPEIAWVGKTE-QALKAEGVEVNVGTF--PFAASGRAMAANDTGGFVKVI 409 Query: 467 CANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 K ++V+G+H+ G E++Q A+A++ G + D V HPT SE L Sbjct: 410 ADAKTDRVLGVHVIGPSAAELVQQGAIAMEFGTSAEDLGMMVFSHPTLSEAL 461 >3LAD-A nrPDB Length = 476 Score = 184 bits (467), Expect = 8e-47, Method: Compositional matrix adjust. Identities = 129/470 (27%), Positives = 235/470 (50%), Gaps = 32/470 (6%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHK-------LGGTCVNVGCVPKKVMWNTA 117 +D +VIG G GG +A ++A+LG + A++E +K LGGTC+NVGC+P K + +++ Sbjct: 4 FDVIVIGAGPGGYVAAIKSAQLGLKTALIEKYKGKEGKTALGGTCLNVGCIPSKALLDSS 63 Query: 118 VHSEFMHDHAD-YGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAF 176 H+ +G + E + + ++D V L + + + + + GH Sbjct: 64 YKFHEAHESFKLHGISTGEVAIDVPTMIARKDQIVRNLTGGVASLIKANGVTLFEGHGKL 123 Query: 177 TSDPKPTIEV---SGKKYTAPHILIATGGMPSTPHESQIPGASLG----ITSDGFFQLEE 229 + K + S + ++++A+G P +IP A + + S G + Sbjct: 124 LAGKKVEVTAADGSSQVLDTENVILASGSKPV-----EIPPAPVDQDVIVDSTGALDFQN 178 Query: 230 LPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEV 289 +PG+ ++GAG I +E+ + + LG++ +++ DK L + D ++ + L G+++ Sbjct: 179 VPGKLGVIGAGVIGLELGSVWARLGAEVTVLEAMDKFLPAVDEQVAKEAQKILTKQGLKI 238 Query: 290 LKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGI 349 L ++V + + V V A + D L+ A+GR P T DL G+ Sbjct: 239 LLGARVTGTEVKNKQVTVKFVDAEGEKSQAF------DKLIVAVGRRPVTTDLLAADSGV 292 Query: 350 QTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYN 409 D++G I VD++ T+V G+YA+GDV A+L A G +A R+ +K ++++Y+ Sbjct: 293 TLDERGFIYVDDYCATSVPGVYAIGDVVRGAMLAHKASEEGVVVAERIAGHK--AQMNYD 350 Query: 410 NIPTVVFSHPPIGTVGLTEDEAIHKYGIE-NVKTYSTSFTPMYHAVTKRKTKCVMKMVCA 468 IP V+++HP I VG TE +A+ G+ NV + F A+ T +K++ Sbjct: 351 LIPAVIYTHPEIAGVGKTE-QALKAEGVAINVGVF--PFAASGRAMAANDTAGFVKVIAD 407 Query: 469 NKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 K ++V+G+H+ G E++Q A+A++ G + D V HP SE L Sbjct: 408 AKTDRVLGVHVIGPSAAELVQQGAIAMEFGTSAEDLGMMVFAHPALSEAL 457 >2YQU-A nrPDB Length = 455 Score = 182 bits (461), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 139/458 (30%), Positives = 221/458 (48%), Gaps = 22/458 (4%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKKVMWNTAVHSEFM 123 YD LVIG G GG +A RAA+LG + VVE K LGGTC+ VGC+P K + T +E + Sbjct: 2 YDLLVIGAGPGGYVAAIRAAQLGMKVGVVEKEKALGGTCLRVGCIPSKALLET---TERI 58 Query: 124 HDHADYGFPSCEGK---FNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP 180 ++ A G + K + + +D V + K+ I +G A F S+ Sbjct: 59 YE-AKKGLLGAKVKGVELDLPALMAHKDKVVQANTQGVEFLFKKNGIARHQGTARFLSER 117 Query: 181 KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG 240 K +E +G++ A +ILIATG P P +Q+ + +TS E+P R ++VG G Sbjct: 118 KVLVEETGEELEARYILIATGSAPLIPPWAQVDYERV-VTSTEALSFPEVPKRLIVVGGG 176 Query: 241 YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK 300 I +E+ + LG++ ++ D++L + D +S + G+ + +V V Sbjct: 177 VIGLELGVVWHRLGAEVIVLEYMDRILPTMDLEVSRAAERVFKKQGLTIRTGVRVTAVVP 236 Query: 301 TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD 360 G V + + + D +L A+GR P T+ LSL G+ TD++G I VD Sbjct: 237 EAKGARVELEGG---------EVLEADRVLVAVGRRPYTEGLSLENAGLSTDERGRIPVD 287 Query: 361 EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP 420 E T V IYA+GDV +L A G + + +DY IP+VV++HP Sbjct: 288 EHLRTRVPHIYAIGDVVRGPMLAHKASEEGIAAVEHMV--RGFGHVDYQAIPSVVYTHPE 345 Query: 421 IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ 480 I VG TE+E + GI K ++ A +T+ +K++ K ++++G+H Sbjct: 346 IAAVGYTEEE-LKAQGI-PYKVGKFPYSASGRARAMGETEGFIKVLAHAKTDRILGVHGI 403 Query: 481 GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 G ++L A+A+ A+ D HP+ SE L Sbjct: 404 GARVGDVLAEAALALFFKASAEDLGRAPHAHPSLSEIL 441 >1DXL-A nrPDB Length = 470 Score = 181 bits (460), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 130/466 (27%), Positives = 241/466 (51%), Gaps = 30/466 (6%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVNVGCVPKKVMWNTA-VHSEFM 123 D ++IGGG GG +A +AA+LG + +E LGGTC+NVGC+P K + +++ ++ E Sbjct: 8 DVVIIGGGPGGYVAAIKAAQLGFKTTCIEKRGALGGTCLNVGCIPSKALLHSSHMYHEAK 67 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPK-- 181 H A++G + + + ++D VS L + K+ + ++G+ F S + Sbjct: 68 HSFANHGVKVSNVEIDLAAMMGQKDKAVSNLTRGIEGLFKKNKVTYVKGYGKFVSPSEIS 127 Query: 182 -PTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLG----ITSDGFFQLEELPGRSVI 236 TIE HI+IATG +PG ++ ++S G L E+P + V+ Sbjct: 128 VDTIEGENTVVKGKHIIIATG-----SDVKSLPGVTIDEKKIVSSTGALALSEIPKKLVV 182 Query: 237 VGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVK 296 +GAGYI +EM + +GS+ +++ +++ + D+ I LE G++ ++V Sbjct: 183 IGAGYIGLEMGSVWGRIGSEVTVVEFASEIVPTMDAEIRKQFQRSLEKQGMKFKLKTKVV 242 Query: 297 EVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGH 356 V + G+++++ + G ++ + D +L + GR P T L+L+K+G++TD G Sbjct: 243 GVDTSGDGVKLTVEPSAGGEQTII----EADVVLVSAGRTPFTSGLNLDKIGVETDKLGR 298 Query: 357 IIVDEFQNTNVKGIYAVGDVCGKALLTPVA----IAAGRKLAHRLFEYKEDSKLDYNNIP 412 I+V+E +TNV G+YA+GDV +L A +A LA ++ +DY+ +P Sbjct: 299 ILVNERFSTNVSGVYAIGDVIPGPMLAHKAEEDGVACVEYLAGKV------GHVDYDKVP 352 Query: 413 TVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEE 472 VV+++P + +VG TE E + + G+E + F A + ++K++ + + Sbjct: 353 GVVYTNPEVASVGKTE-EQVKETGVE-YRVGKFPFMANSRAKAIDNAEGLVKIIAEKETD 410 Query: 473 KVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 K++G+H+ E++ A+A++ A+ D HPT SE + Sbjct: 411 KILGVHIMAPNAGELIHEAAIALQYDASSEDIARVCHAHPTMSEAI 456 >1EBD-A nrPDB Length = 455 Score = 179 bits (454), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 130/459 (28%), Positives = 221/459 (48%), Gaps = 26/459 (5%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHD 125 + LV+G G GG +A RAA+LG + +VE LGG C+NVGC+P K + + + E Sbjct: 5 ETLVVGAGPGGYVAAIRAAQLGQKVTIVEKGNLGGVCLNVGCIPSKALISASHRYEQAKH 64 Query: 126 HADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIE 185 + G + ++ ++E + + V +L + L + +EI++G A F T+ Sbjct: 65 SEEMGIKAENVTIDFAKVQEWKASVVKKLTGGVEGLLKGNKVEIVKGEAYFVD--ANTVR 122 Query: 186 V----SGKKYTAPHILIATGG----MPSTPHESQIPGASLGITSDGFFQLEELPGRSVIV 237 V S + YT + +IATG +P+ ++I + S G L E+P V++ Sbjct: 123 VVNGDSAQTYTFKNAIIATGSRPIELPNFKFSNRI------LDSTGALNLGEVPKSLVVI 176 Query: 238 GAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKE 297 G GYI +E+ + G+K +++ ++L F+ ++ + L+ GVEV+ + K Sbjct: 177 GGGYIGIELGTAYANFGTKVTILEGAGEILSGFEKQMAAIIKKRLKKKGVEVVTNALAKG 236 Query: 298 VKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHI 357 ++ G+ V+ T D D +L +GR PNT +L L ++GI+ ++G I Sbjct: 237 AEEREDGVTVTY------EANGETKTIDADYVLVTVGRRPNTDELGLEQIGIKMTNRGLI 290 Query: 358 IVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFS 417 VD+ T+V I+A+GD+ L A G+ A + + S +DY IP VVFS Sbjct: 291 EVDQQCRTSVPNIFAIGDIVPGPALAHKASYEGKVAAEAIAGHP--SAVDYVAIPAVVFS 348 Query: 418 HPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGI 477 P +VG E +A GI +V F A+ T +K+V ++ ++G Sbjct: 349 DPECASVGYFEQQA-KDEGI-DVIAAKFPFAANGRALALNDTDGFLKLVVRKEDGVIIGA 406 Query: 478 HMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSE 516 + G +M+ +A++ G T D T+ HPT E Sbjct: 407 QIIGPNASDMIAELGLAIEAGMTAEDIALTIHAHPTLGE 445 >2EQ6-A nrPDB Length = 464 Score = 175 bits (444), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 141/458 (30%), Positives = 228/458 (49%), Gaps = 17/458 (3%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFM 123 +YD +VIG G GG +A RAA+LG + VE+ ++GG C+NVGC+P K + + A + Sbjct: 6 TYDLIVIGTGPGGYHAAIRAAQLGLKVLAVEAGEVGGVCLNVGCIPTKALLHAAETLHHL 65 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 +G + + + + + RD V +L L + +E++RG A PK Sbjct: 66 KVAEGFGL-KAKPELDLKKLGGWRDQVVKKLTGGVGTLLKGNGVELLRGFARLVG-PK-E 122 Query: 184 IEVSGKKYTAPHILIATGGMPSTPHESQ-IPGASLGITSDGFFQLEE-LPGRSVIVGAGY 241 +EV G++Y A +++ATG S P E + P S ++EE LP R +++G G Sbjct: 123 VEVGGERYGAKSLILATG---SEPLELKGFPFGEDVWDSTRALKVEEGLPKRLLVIGGGA 179 Query: 242 IAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKT 301 + +E+ + LG++ +L+ ++L D + LE G+ V ++ +K Sbjct: 180 VGLELGQVYRRLGAEVTLIEYMPEILPQGDPETAALLRRALEKEGIRVRTKTKAVGYEKK 239 Query: 302 LSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDE 361 GL V + A VD +L A+GR P T+ L L K G++ D++G I V+ Sbjct: 240 KDGLHVRLEPAE----GGEGEEVVVDKVLVAVGRKPRTEGLGLEKAGVKVDERGFIRVNA 295 Query: 362 FQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPI 421 T+V G+YA+GD LL A+ G A +DS DY +P+VV++ P Sbjct: 296 RMETSVPGVYAIGDAARPPLLAHKAMREGLIAAEN--AAGKDSAFDY-QVPSVVYTSPEW 352 Query: 422 GTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQG 481 VGLTE+EA K VK A+T + ++K+V + + ++G+ + G Sbjct: 353 AGVGLTEEEA--KRAGYKVKVGKFPLAASGRALTLGGAEGMVKVVGDEETDLLLGVFIVG 410 Query: 482 LGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELV 519 E++ A+A++MGAT D TV HPT SE L+ Sbjct: 411 PQAGELIAEAALALEMGATLTDLALTVHPHPTLSESLM 448 >5U8W-A nrPDB Length = 481 Score = 173 bits (439), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 141/485 (29%), Positives = 242/485 (49%), Gaps = 62/485 (12%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESH-------KLGGTCVNVGCVPKKVMWNTA 117 +D +VIG G GG +A RAA+LG + A +E + LGGTC+NVGC+P K + +++ Sbjct: 8 FDVVVIGAGPGGYVAAIRAAQLGLKTACIEKYIGKEGKVALGGTCLNVGCIPSKALLDSS 67 Query: 118 VHSEFMHDHADYGFPSCEGKFNWRVIKEKR-----DAYVSRLNAIYQN------NLTKSH 166 Y + + F I+ K A V+R I +N L K++ Sbjct: 68 -----------YKYHEAKEAFKVHGIEAKGVTIDVPAMVARKANIVKNLTGGIATLFKAN 116 Query: 167 -IEIIRGHAAFTSDPKPTIEVSG-----KKYTAPHILIATGGMPSTPHESQIPGASLG-- 218 + GH ++ + +EV+G + A +++IA+G P +IP A L Sbjct: 117 GVTSFEGHGKLLANKQ--VEVTGLDGKTQVLEAENVIIASGSRPV-----EIPPAPLTDD 169 Query: 219 --ITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMIST 276 + S G + + +P + ++GAG I +E+ + + LG++ +++ DK L + D I+ Sbjct: 170 IIVDSTGALEFQAVPKKLGVIGAGVIGLELGSVWARLGAEVTVLEALDKFLPAADEQIAK 229 Query: 277 NCTEELENAGVEVLKFSQV--KEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIG 334 + L G+ + ++V EVKK + V+ A + D L+ A+G Sbjct: 230 EALKVLTKQGLNIRLGARVTASEVKK--KQVTVTFTDANGEQKETF------DKLIVAVG 281 Query: 335 RVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLA 394 R P T DL G+ D++G I VD+ T+V G++A+GDV A+L A G +A Sbjct: 282 RRPVTTDLLAADSGVTLDERGFIYVDDHCKTSVPGVFAIGDVVRGAMLAHKASEEGVMVA 341 Query: 395 HRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIE-NVKTYSTSFTPMYHA 453 R+ +K ++++Y+ IP+V+++HP I VG TE + + G+E NV T+ F A Sbjct: 342 ERIAGHK--AQMNYDLIPSVIYTHPEIAWVGKTE-QTLKAEGVEVNVGTF--PFAASGRA 396 Query: 454 VTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPT 513 + T ++K++ K ++V+G+H+ G E++Q A+ ++ G + D V HPT Sbjct: 397 MAANDTTGLVKVIADAKTDRVLGVHVIGPSAAELVQQGAIGMEFGTSAEDLGMMVFSHPT 456 Query: 514 SSEEL 518 SE L Sbjct: 457 LSEAL 461 >3URH-A nrPDB Length = 491 Score = 172 bits (435), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 133/470 (28%), Positives = 222/470 (47%), Gaps = 36/470 (7%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKKVMWNTAVHSEF 122 +YD +VIG G GG A +AA+LG + AVVE GGTC+NVGC+P K + +H+ Sbjct: 25 AYDLIVIGSGPGGYVCAIKAAQLGMKVAVVEKRSTYGGTCLNVGCIPSKAL----LHASE 80 Query: 123 MHDHADYGFPS-----CEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFT 177 M A +G + K N + + +DA V K+ I+ +G Sbjct: 81 MFHQAQHGLEALGVEVANPKLNLQKMMAHKDATVKSNVDGVSFLFKKNKIDGFQGTGKVL 140 Query: 178 SDPKPTIEVSGKK-----YTAPHILIATGGMPSTPHESQIPGASLG------ITSDGFFQ 226 K + V+ +K A +++IATG + IPG + ++S G Sbjct: 141 GQGK--VSVTNEKGEEQVLEAKNVVIATG-----SDVAGIPGVEVAFDEKTIVSSTGALA 193 Query: 227 LEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAG 286 LE++P ++VG G I +E+ + + LG+K +++ D +L D ++ L G Sbjct: 194 LEKVPASMIVVGGGVIGLELGSVWARLGAKVTVVEFLDTILGGMDGEVAKQLQRMLTKQG 253 Query: 287 VEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNK 346 ++ ++V K+ G +V+ G + D + +L A GR P+T L L K Sbjct: 254 IDFKLGAKVTGAVKSGDGAKVTFEPVKGGEATTL----DAEVVLIATGRKPSTDGLGLAK 309 Query: 347 LGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKL 406 G+ D +G + +D T++ G+YA+GDV +L A G +A + + + Sbjct: 310 AGVVLDSRGRVEIDRHFQTSIAGVYAIGDVVRGPMLAHKAEDEGVAVAEII--AGQAGHV 367 Query: 407 DYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMV 466 +Y+ IP VV++ P + +VG TE+E + G+ K FT A +T +K++ Sbjct: 368 NYDVIPGVVYTQPEVASVGKTEEE-LKAAGVA-YKIGKFPFTANGRARAMLQTDGFVKIL 425 Query: 467 CANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSE 516 + ++V+G H+ G G EM+ AV ++ G + D T HPT SE Sbjct: 426 ADKETDRVLGGHIIGFGAGEMIHEIAVLMEFGGSSEDLGRTCHAHPTMSE 475 >5J5Z-A nrPDB Length = 496 Score = 171 bits (432), Expect = 9e-43, Method: Compositional matrix adjust. Identities = 146/485 (30%), Positives = 228/485 (47%), Gaps = 51/485 (10%) Query: 57 PAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKKVMWN 115 P A D VIG G GG +A +AA+LG + +E ++ LGGTC+NVGC+P K + N Sbjct: 21 PGADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLN 80 Query: 116 TAVHSEFMH--DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGH 173 + + H D A G E + N + E++ V L + ++ + + G+ Sbjct: 81 NSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGY 140 Query: 174 AAFTSDPKPTI---EVSGKKYTAPHILIATGGMPSTPHESQIPGASLG----ITSDGFFQ 226 T + T + + +ILIATG TP PG ++ ++S G Sbjct: 141 GKITGKNQVTATKADGGTQVIDTKNILIATGS-EVTP----FPGITIDEDTIVSSTGALS 195 Query: 227 LEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLR-SFDSMISTNCTEELENA 285 L+++P + V++GAG I VE+ + LG+ + + V D IS N L+ Sbjct: 196 LKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQ 255 Query: 286 GVEVLKFSQVK-EVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSL 344 G + ++V KK+ ++VS+ A G+ V+T D LL IGR P TK+L L Sbjct: 256 GFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVIT----CDVLLVCIGRRPFTKNLGL 311 Query: 345 NKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDS 404 +LGI+ D +G I V+ T + IYA+GDV AG LAH+ ED Sbjct: 312 EELGIELDPRGRIPVNTRFQTKIPNIYAIGDV-----------VAGPMLAHK----AEDE 356 Query: 405 -------------KLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMY 451 +DYN +P+V+++HP + VG +E E + + GIE K F Sbjct: 357 GIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSE-EQLKEEGIE-YKVGKFPFAANS 414 Query: 452 HAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIH 511 A T T ++K++ ++V+G H+ G G EM+ A+A++ GA+ H Sbjct: 415 RAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEVIARVCHAH 474 Query: 512 PTSSE 516 PT SE Sbjct: 475 PTLSE 479 >4JDR-A nrPDB Length = 474 Score = 166 bits (420), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 134/467 (28%), Positives = 224/467 (47%), Gaps = 40/467 (8%) Query: 68 LVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKKVMWNTAVHSEFMHDH 126 +V+G G G ++A R A+LG +VE + LGG C+NVGC+P K + + A E Sbjct: 10 VVLGAGPAGYSAAFRCADLGLETVIVERYNTLGGVCLNVGCIPSKALLHVAKVIEEAKAL 69 Query: 127 ADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEV 186 A++G E K + I+ ++ +++L ++++ G FT T+EV Sbjct: 70 AEHGIVFGEPKTDIDKIRTWKEKVINQLTGGLAGMAKGRKVKVVNGLGKFTG--ANTLEV 127 Query: 187 SGKK----YTAPHILIATGG----MPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVG 238 G+ + +IA G +P PHE + ++D +L+E+P R +++G Sbjct: 128 EGENGKTVINFDNAIIAAGSRPIQLPFIPHED----PRIWDSTDAL-ELKEVPERLLVMG 182 Query: 239 AGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEV 298 G I +EM + ALGS+ ++ D+V+ + D I T+ + ++ ++V V Sbjct: 183 GGIIGLEMGTVYHALGSQIDVVEMFDQVIPAADKDIVKVFTKRISKK-FNLMLETKVTAV 241 Query: 299 KKTLSGLEVSM----VTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDK 354 + G+ V+M A P R D +L AIGRVPN K+L K G++ DD+ Sbjct: 242 EAKEDGIYVTMEGKKAPAEPQRY---------DAVLVAIGRVPNGKNLDAGKAGVEVDDR 292 Query: 355 GHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTV 414 G I VD+ TNV I+A+GD+ G+ +L + G A + K D IP++ Sbjct: 293 GFIRVDKQLRTNVPHIFAIGDIVGQPMLAHKGVHEGHVAAEVIAGKKH--YFDPKVIPSI 350 Query: 415 VFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKC---VMKMVCANKE 471 ++ P + VGLTE EA K GI +Y T+ P + + C + K++ + Sbjct: 351 AYTEPEVAWVGLTEKEAKEK-GI----SYETATFPWAASGRAIASDCADGMTKLIFDKES 405 Query: 472 EKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 +V+G + G E+L +A++MG D T+ HPT E + Sbjct: 406 HRVIGGAIVGTNGGELLGEIGLAIEMGCDAEDIALTIHAHPTLHESV 452 >4YWO-A nrPDB Length = 462 Score = 162 bits (410), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 135/458 (29%), Positives = 221/458 (48%), Gaps = 41/458 (8%) Query: 69 VIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVP-KKVMWNTAVHSEFMHDHA 127 +IG G+ G A+ +A ELG + ++ ++GGTCVNVGCVP K++++ ++ + Sbjct: 20 IIGYGAAGFAAMIKANELGVKPVLIGKGEIGGTCVNVGCVPSKRMLYIAEIYKKAREVTG 79 Query: 128 DYGFPSCEGKFNWRVIKEKRDAYVSRLNAI-YQNNLTKSHIEIIRGHAAFTSDPKPTIEV 186 +P + +EK D V + Y++ L+ +E+I+G A F S ++V Sbjct: 80 SEVYPP------FSSFQEK-DGLVQEMRKTKYEDLLSYYDVELIQGEARFIS--PHAVKV 130 Query: 187 SGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEEL--PGRSV----IVGAG 240 +G+ A +IATG P P +IP G+ GF+ E P R + ++G Sbjct: 131 NGQVIEAEKFVIATGSSPLIP---RIP----GLDKVGFWTNREALSPDRRIDSLAVIGGR 183 Query: 241 YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK 300 +A+E A + S + + +++ R ++ ++ S +EN GV V+ VKEV+K Sbjct: 184 ALALEFAQMYSRMKVEVAILQRSPVLIPDWEPEASVEARRIMENDGVAVVTGVNVKEVRK 243 Query: 301 TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD 360 + ++ V + D +L A GR PN DL L G++ +++G I VD Sbjct: 244 GAGKIVITDKGEV-----------EADEILLATGRKPNV-DLGLENAGVRLNERGGIKVD 291 Query: 361 EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP 420 + T+ IYA GDV G +L +A G +A ++D N +P V+F+ P Sbjct: 292 DELRTDNPHIYAAGDVLGGKMLEALAGRQG-SIATENALTGSHKRVDENAVPQVIFTQPN 350 Query: 421 IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ 480 + VGLTE EA K G + S + R +KMV N ++VG+H Sbjct: 351 LARVGLTEAEARAKEGEVEARVLPMSSVAKAEIINSRLG--FVKMVTMNG--RIVGVHAV 406 Query: 481 GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 G EM+ A+A++ GAT D +TV + PT +E L Sbjct: 407 GENVAEMIGEAALAIRFGATVHDLIDTVHMFPTIAESL 444 >6CMZ-A nrPDB Length = 466 Score = 161 bits (407), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 131/466 (28%), Positives = 211/466 (45%), Gaps = 40/466 (8%) Query: 68 LVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHA 127 LVIGGG GG +A RA +LG +VE +LGGTC+N+GC+P K + + A E HA Sbjct: 12 LVIGGGPGGYVAAIRAGQLGIPTVLVERDRLGGTCLNIGCIPSKALIHVADAFEQACGHA 71 Query: 128 DYGFPSCEGKFNWRVIKEK---------RDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTS 178 EG RV + +D V RL L KS + ++ G A Sbjct: 72 G------EGALGIRVRAPEIDIAKSVAWKDGIVDRLTRGVGALLKKSGVRVLHGEARVID 125 Query: 179 DPKPTIEVSGK--KYTAPHILIATGG----MPSTPHESQIPGASLGITSDGFFQLEELPG 232 + +G + H+L+ATG +PS P + ++S LP Sbjct: 126 GKTVEVVSAGHAVRIGCEHLLLATGSEPVELPSMPFGGHV------VSSTDALSPATLPK 179 Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF 292 R V+VGAGYI +E+ + LG S++ ++VL ++D+ + + L GV + Sbjct: 180 RLVVVGAGYIGLELGIVYRKLGVDVSVVEAAERVLPAYDAELVRPVADSLARLGVRLWLG 239 Query: 293 SQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD 352 +V + K + V LP D +L A+GR P L L + + Sbjct: 240 HKVLGLDKH-GAVRVQAADGAEQTLP-------ADRVLVAVGRRPRVDGFGLETLMLDRN 291 Query: 353 DKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIP 412 + + +D+ T+++ ++A+GDV G+ +L A+A G +A + + + IP Sbjct: 292 GRA-LRIDDTCRTSMRNVWAIGDVAGEPMLAHRAMAQGEMVAELIAGRRR--QFMPAAIP 348 Query: 413 TVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEE 472 V F+ P I T G + D+A H G++ + + S F A+T + T +++V Sbjct: 349 AVCFTDPEIVTAGWSPDDA-HAAGVDCL-SASFPFAANGRAMTLQATDGFVRVVARRDNH 406 Query: 473 KVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 +VG G G E+ F+ +++MGA D T+ HPT E L Sbjct: 407 LIVGWQAVGRGVSELAAAFSQSLEMGARLEDIGGTIHAHPTLGEAL 452 >1V59-A nrPDB Length = 478 Score = 160 bits (406), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 136/464 (29%), Positives = 223/464 (48%), Gaps = 17/464 (3%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVNVGCVPKKVMWNTAVHSEF 122 S+D ++IGGG G +A +AA+LG A VE KLGGTC+NVGC+P K + N + Sbjct: 5 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQ 64 Query: 123 MHDHADYGFPSCEG--KFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP 180 MH A G K N ++ +D V +L + K+ + +G+ +F + Sbjct: 65 MHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDET 124 Query: 181 KPTIE-VSGKKYTAP--HILIATGGMPSTPHE-SQIPGASLG----ITSDGFFQLEELPG 232 K + V G + T HIL + +T E + PG + ++S G L+E+P Sbjct: 125 KIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPK 184 Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF 292 R I+G G I +EM + S LGSK +++ ++ S D ++ + L+ G++ Sbjct: 185 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLS 244 Query: 293 SQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD 352 ++V K+ V +V + + + LL A+GR P L K+G++ D Sbjct: 245 TKVISAKRNDDKNVVEIVVEDTKTNKQENL--EAEVLLVAVGRRPYIAGLGAEKIGLEVD 302 Query: 353 DKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIP 412 +G +++D+ N+ I VGDV +L A G L ++YNNIP Sbjct: 303 KRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEML--KTGHGHVNYNNIP 360 Query: 413 TVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEE 472 +V++SHP + VG TE E + + GI+ K F A T + T+ +K++ +K E Sbjct: 361 SVMYSHPEVAWVGKTE-EQLKEAGID-YKIGKFPFAANSRAKTNQDTEGFVKILIDSKTE 418 Query: 473 KVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSE 516 +++G H+ G EM+ +A++ GA+ D HPT SE Sbjct: 419 RILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSE 462 >6AON-A nrPDB Length = 478 Score = 158 bits (399), Expect = 7e-39, Method: Compositional matrix adjust. Identities = 124/477 (25%), Positives = 220/477 (46%), Gaps = 45/477 (9%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLG-------GTCVNVGCVPKKVMWNT 116 +D +VIG G GG +A RAA+LG A +++ + G GTC NVGC+P K + + Sbjct: 7 QFDVVVIGAGPGGYIAAIRAAQLGMSVACIDAWQNGQGGPAPGGTCTNVGCIPSKALLQS 66 Query: 117 AVHSEFMHDH-ADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNN-------LTKSHIE 168 + H E + H A++G + + K D + R N + + N K+ + Sbjct: 67 SEHYEQANHHFAEHGIEV-------KGVSLKLDTLIGRKNTVVKQNNDGILYLFKKNKVT 119 Query: 169 IIRGHAAFTS--DPKPTIEVSGK---KYTAPHILIATGG----MPSTPHESQIPGASLGI 219 G AF D +I+V+G A H+++ATG +P P + + + Sbjct: 120 YFHGKGAFAGQVDGGWSIKVTGTTDADLVAKHVIVATGSSARELPGLPFDEKNI-----L 174 Query: 220 TSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCT 279 ++DG + +P + ++GAG I +EM + LG++ +++ + L + D ++ Sbjct: 175 SNDGALNIGAVPKKLGVIGAGVIGLEMGSVWRRLGAEVTILEAMPEFLAAADQQVAKEAL 234 Query: 280 EELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNT 339 + G+++ ++ E+K + V V A ++ VD L+ +IGRVP T Sbjct: 235 KSFAKQGLDIQTGVKIGEIKAAAKSITVPYVDAKGAEQKLV-----VDKLIVSIGRVPYT 289 Query: 340 KDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFE 399 L+ +G++ D++G + VDE TN+ ++AVGDV +L A G +A R+ Sbjct: 290 GGLNAEAVGLKLDERGFVAVDEDCKTNLPNVWAVGDVVRGPMLAHKAEEEGVAVAERI-- 347 Query: 400 YKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKT 459 + +++ +P V+++ P I VG TE + + G E K S F A T Sbjct: 348 AGQHGHVNFATVPWVIYTSPEIAWVGKTEQQ-LKAEGRE-YKAGSFPFMANGRARALGDT 405 Query: 460 KCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSE 516 K++ K ++V+G+H+ G E++ ++ D HPT SE Sbjct: 406 TGFAKVIADAKTDEVLGVHIIGPMASELISEAVTIMEFRGAAEDIARICHAHPTLSE 462 >6BZ0-A nrPDB Length = 480 Score = 155 bits (391), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 121/467 (25%), Positives = 224/467 (47%), Gaps = 29/467 (6%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESH------KLGGTCVNVGCVPKKVMWNTA 117 +D +VIGGG GG +A RAA+LG + A +E LGGTC+NVGC+P K + +++ Sbjct: 7 QFDLVVIGGGPGGYEAAIRAAQLGFKVACIEKRIHNGKPSLGGTCLNVGCIPSKALLDSS 66 Query: 118 -VHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAF 176 + + +H AD+G + E F+ + ++D V +L L + IE ++G Sbjct: 67 HRYEDTVHHLADHGITTGEVNFDLAKLLARKDKIVDQLTGGIDQLLKGNGIEWLKGTGKL 126 Query: 177 TSDPKPTI---EVSGKKYTAPHILIATGGMPSTPHESQIPGASLG----ITSDGFFQLEE 229 + K E + ++++A+G +P IP A + + S G E Sbjct: 127 LAGKKVEFVPHEGETQILEPKYVILASGSVPVN-----IPVAPVDQDIIVDSTGALNFPE 181 Query: 230 LPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEV 289 +P R ++GAG I +E+ + LG++ + D L D +S + L G+++ Sbjct: 182 VPKRLGVIGAGVIGLELGSVWRRLGAEVVVFEAMDAFLPMADKALSKEYQKILTKQGLDI 241 Query: 290 LKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGI 349 ++V + ++G EV++ G T D L+ +GR + L GI Sbjct: 242 RIGAKVSGTE--VNGREVTVKYTQAGEDKEQTF----DKLIVCVGRKAYAEGLLAEDSGI 295 Query: 350 QTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYN 409 + ++G + V++ T+V+G+YA+GD+ +L A+ G R+ + ++++Y+ Sbjct: 296 KLTERGLVEVNDHCATSVEGVYAIGDLVRGPMLAHKAMEEGVMAVERI--HGHAAQVNYD 353 Query: 410 NIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCAN 469 I +++++HP VGLTE++A K VKT F A+ + +K V Sbjct: 354 TIISIIYTHPEAAWVGLTEEQAKEKG--HEVKTGQFGFAVNGRALAAGEGAGFVKFVADA 411 Query: 470 KEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSE 516 K ++++G+H+ G +++ +A++ ++ D HPT SE Sbjct: 412 KTDRLLGMHVIGPAASDIVHQGMIALEFVSSVEDLQLMTFGHPTFSE 458 >1ZK7-A nrPDB Length = 467 Score = 149 bits (375), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 131/437 (29%), Positives = 211/437 (48%), Gaps = 28/437 (6%) Query: 69 VIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHA- 127 VIG G +A+A +A E GA+ ++E +GGTCVNVGCVP K+M A + + Sbjct: 9 VIGSGGAAMAAALKAVEQGAQVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRESPF 68 Query: 128 DYGFPSCEGKFNWRVIKEKRDAYVSRL-NAIYQNNLTKS-HIEIIRGHAAFTSDPKPTIE 185 D G + + + ++ A V L +A Y+ L + I ++ G A F D T+ Sbjct: 69 DGGIAATVPTIDRSKLLAQQQARVDELRHAKYEGILGGNPAITVVHGEARFKDDQSLTVR 128 Query: 186 VS--GKKYTA-PHILIATGGMPSTPHESQIPG--ASLGITSDGFFQLEELPGRSVIVGAG 240 ++ G++ L+ATG P+ P IPG S TS + +P R ++G+ Sbjct: 129 LNEGGERVVMFDRCLVATGASPAVP---PIPGLKESPYWTSTEALASDTIPERLAVIGSS 185 Query: 241 YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK 300 +A+E+A + LGSK +++ R+ R D I T G+EVL+ +Q +V Sbjct: 186 VVALELAQAFARLGSKVTVLARNTLFFRE-DPAIGEAVTAAFRAEGIEVLEHTQASQVAH 244 Query: 301 TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD 360 + G V +T G L D LL A GR PNT+ L+L+ G+ + +G I++D Sbjct: 245 -MDGEFV--LTTTHGEL-------RADKLLVATGRTPNTRSLALDAAGVTVNAQGAIVID 294 Query: 361 EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP 420 + T+ IYA GD + V +AA + D+ LD +P VVF+ P Sbjct: 295 QGMRTSNPNIYAAGDCTDQPQF--VYVAAAAGTRAAINMTGGDAALDLTAMPAVVFTDPQ 352 Query: 421 IGTVGLTEDEAIHKYGIE-NVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHM 479 + TVG +E EA H GIE + +T + P A+ T+ +K+V +++G+ Sbjct: 353 VATVGYSEAEA-HHDGIETDSRTLTLDNVP--RALANFDTRGFIKLVIEEGSHRLIGVQA 409 Query: 480 QGLGCDEMLQGFAVAVK 496 E++Q A+A++ Sbjct: 410 VAPEAGELIQTAALAIR 426 >1LVL-A nrPDB Length = 458 Score = 143 bits (360), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 115/444 (25%), Positives = 208/444 (46%), Gaps = 27/444 (6%) Query: 79 SARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEG-- 136 +A RA +LG +VE LGGTC+N+GC+P K + + A E H + + PS G Sbjct: 20 AAIRAGQLGIPTVLVEGQALGGTCLNIGCIPSKALIHVA---EQFHQASRFTEPSPLGIS 76 Query: 137 ----KFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYT 192 + + +D V RL L K ++++ G A + +EV G++ Sbjct: 77 VASPRLDIGQSVAWKDGIVDRLTTGVAALLKKHGVKVVHGWAKVLDGKQ--VEVDGQRIQ 134 Query: 193 APHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSA 252 H+L+ATG S+ +P I+S + LP V+VG GYI +E+ Sbjct: 135 CEHLLLATG--SSSVELPMLPLGGPVISSTEALAPKALPQHLVVVGGGYIGLELGIAYRK 192 Query: 253 LGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTA 312 LG++ S++ +++L ++DS ++ E L+ G+ + + ++ G E + A Sbjct: 193 LGAQVSVVEARERILPTYDSELTAPVAESLKKLGIAL-------HLGHSVEGYENGCLLA 245 Query: 313 VPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYA 372 G+ + + + D +L A+GR P TK +L L ++ + I +DE T++ ++A Sbjct: 246 NDGKGGQLRL--EADRVLVAVGRRPRTKGFNLECLDLKMNGAA-IAIDERCQTSMHNVWA 302 Query: 373 VGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAI 432 +GDV G+ +L A+A G +A + + + + I V F+ P + VG T ++A Sbjct: 303 IGDVAGEPMLAHRAMAQGEMVAEII--AGKARRFEPAAIAAVCFTDPEVVVVGKTPEQA- 359 Query: 433 HKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFA 492 + G++ + F A++ +++V ++G G+ E+ FA Sbjct: 360 SQQGLDCI-VAQFPFAANGRAMSLESKSGFVRVVARRDNHLILGWQAVGVAVSELSTAFA 418 Query: 493 VAVKMGATKADFDNTVAIHPTSSE 516 +++MGA D T+ HPT E Sbjct: 419 QSLEMGACLEDVAGTIHAHPTLGE 442 >3II4-A nrPDB Length = 466 Score = 138 bits (348), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 136/474 (28%), Positives = 216/474 (45%), Gaps = 37/474 (7%) Query: 60 GAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTA-- 117 G++ YD +V+G G GG +A RAA+LG A+VE GG C+NVGC+P K + A Sbjct: 1 GSMTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIPSKALLRNAEL 60 Query: 118 VHSEFMHDHADYGFPSCEGKFNW-------RVIKEKRDAYVSRLNAIYQNNLTKSHIEII 170 VH F D +G S E F++ R + E R A V L + K+ I I Sbjct: 61 VHI-FTKDAKAFGI-SGEVTFDYGIAYDRSRKVAEGRVAGVHFL-------MKKNKITEI 111 Query: 171 RGHAAFTSDPKPTIEVSG---KKYTAPHILIATGGMPSTPHESQIPGASLG---ITSDGF 224 G+ F ++++ + T + +IATG +PG SL +T + Sbjct: 112 HGYGTFADANTLLVDLNDGGTESVTFDNAIIATGSSTRL-----VPGTSLSANVVTYEEQ 166 Query: 225 FQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELEN 284 ELP +I GAG I +E +L G +++ + L + D+ +S ++ + Sbjct: 167 ILSRELPKSIIIAGAGAIGMEFGYVLKNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKK 226 Query: 285 AGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSL 344 GV +L ++V+ + G +V++ G + + +L AIG PN + L Sbjct: 227 LGVTILTATKVESIAD--GGSQVTVTVTKDGVAQEL----KAEKVLQAIGFAPNVEGYGL 280 Query: 345 NKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDS 404 +K G+ D+ I VD++ TNV IYA+GDV G L VA A G A + + + Sbjct: 281 DKAGVALTDRKAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLT 340 Query: 405 KLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMK 464 D+ +P F P + + GLTE +A ++ +V FT A +K Sbjct: 341 LGDHRMLPRATFCQPNVASFGLTEQQARNEG--YDVVVAKFPFTANAKAHGVGDPSGFVK 398 Query: 465 MVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 +V K +++G H+ G E+L +A + T ++ V HPT SE L Sbjct: 399 LVADAKHGELLGGHLVGHDVAELLPELTLAQRWDLTASELARNVHTHPTMSEAL 452 >1OJT-A nrPDB Length = 482 Score = 133 bits (334), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 141/479 (29%), Positives = 227/479 (47%), Gaps = 39/479 (8%) Query: 61 AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKK-VMWNTAV 118 A A YD +V+GGG GG ++A AA+ G + A+VE +K LGG C+NVGC+P K ++ N AV Sbjct: 3 ADAEYDVVVLGGGPGGYSAAFAAADEGLKVAIVERYKTLGGVCLNVGCIPSKALLHNAAV 62 Query: 119 HSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTS 178 E H A+ G E + + +++ +D VSRL +++I+G F Sbjct: 63 IDEVRHLAAN-GIKYPEPELDIDMLRAYKDGVVSRLTGGLAGMAKSRKVDVIQGDGQFL- 120 Query: 179 DPKPTIEVS---GKKY--TAP----------HILIATGG----MPSTPHESQIPGASLGI 219 DP +EVS G Y AP + +IA G +P P + +I I Sbjct: 121 DPH-HLEVSLTAGDAYEQAAPTGEKKIVAFKNCIIAAGSRVTKLPFIPEDPRI------I 173 Query: 220 TSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCT 279 S G L+E+PG+ +I+G G I +EM + S LGS+ ++ D +++ D + Sbjct: 174 DSSGALALKEVPGKLLIIGGGIIGLEMGTVYSTLGSRLDVVEMMDGLMQGADRDLVKVWQ 233 Query: 280 EELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNT 339 ++ E ++ ++ V+ G+ V+ A + P D +L A GR PN Sbjct: 234 KQNEYRFDNIMVNTKTVAVEPKEDGVYVTFEGANAPKEPQR-----YDAVLVAAGRAPNG 288 Query: 340 KDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFE 399 K +S K G+ D+G I VD+ TNV IYA+GD+ G+ +L A+ G A Sbjct: 289 KLISAEKAGVAVTDRGFIEVDKQMRTNVPHIYAIGDIVGQPMLAHKAVHEGHVAAENCAG 348 Query: 400 YKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKT 459 +K + D IP V ++ P + VG TE A K + + + A+ Sbjct: 349 HK--AYFDARVIPGVAYTSPEVAWVGETELSA--KASARKITKANFPWAASGRAIANGCD 404 Query: 460 KCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 K K++ + +++G + G +M+ +A++MG AD T+ HPT E + Sbjct: 405 KPFTKLIFDAETGRIIGGGIVGPNGGDMIGEVCLAIEMGCDAADIGKTIHPHPTLGESI 463 >5U25-A nrPDB Length = 602 Score = 129 bits (324), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 140/479 (29%), Positives = 226/479 (47%), Gaps = 39/479 (8%) Query: 61 AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKK-VMWNTAV 118 A A YD +V+GGG GG ++A AA+ G + A+VE +K LGG C+NVGC+P K ++ N AV Sbjct: 122 ADAEYDVVVLGGGPGGYSAAFAAADEGLKVAIVERYKTLGGVCLNVGCIPSKALLHNAAV 181 Query: 119 HSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTS 178 E H A+ G E + + +++ +D VSRL +++I+G F Sbjct: 182 IDEVRHLAAN-GIKYPEPELDIDMLRAYKDGVVSRLTGGLAGMAKSRKVDVIQGDGQFL- 239 Query: 179 DPKPTIEVS---GKKY--TAP----------HILIATGG----MPSTPHESQIPGASLGI 219 DP +EVS G Y AP + +IA G +P P + +I I Sbjct: 240 DPH-HLEVSLTAGDAYEQAAPTGEKKIVAFKNCIIAAGSRVTKLPFIPEDPRI------I 292 Query: 220 TSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCT 279 S G L+E+PG+ +I+G G I +EM + S LGS+ ++ D +++ D + Sbjct: 293 DSSGALALKEVPGKLLIIGGGIIGLEMGTVYSTLGSRLDVVEMMDGLMQGADRDLVKVWQ 352 Query: 280 EELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNT 339 ++ E ++ ++ V+ G+ V+ A + P D +L A GR PN Sbjct: 353 KQNEYRFDNIMVNTKTVAVEPKEDGVYVTFEGANAPKEP-----QRYDAVLVAAGRAPNG 407 Query: 340 KDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFE 399 K +S K G+ D+G I VD+ TNV IYA+GD+ G+ +L A+ G A Sbjct: 408 KLISAEKAGVAVTDRGFIEVDKQMRTNVPHIYAIGDIVGQPMLAHKAVHEGHVAAENCAG 467 Query: 400 YKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKT 459 +K + D IP V ++ P + VG TE A K + + + A+ Sbjct: 468 HK--AYFDARVIPGVAYTSPEVAWVGETELSA--KASGRKITKANFPWAASGRAIANGCD 523 Query: 460 KCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 K++ + +++G + G +M+ +A++MG AD T+ HPT E + Sbjct: 524 NGFTKLIFDAETGRIIGGGIVGPNGGDMIGEVCLAIEMGCDAADIGKTIHPHPTLGESI 582 >2QAE-A nrPDB Length = 468 Score = 127 bits (319), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 116/452 (25%), Positives = 215/452 (47%), Gaps = 32/452 (7%) Query: 82 RAAELGARAAVVESH-KLGGTCVNVGCVPKKVMWN-TAVHSEFMHDHADYGFPSCEG-KF 138 +AA+LG + A VE LGGTC+NVGC+P K + + T ++ + + A YG EG Sbjct: 20 KAAQLGMKTACVEKRGALGGTCLNVGCIPSKALLHATHLYHDAHANFARYGLMGGEGVTM 79 Query: 139 NWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSG-----KKYTA 193 + ++++++ V L + K+ + +G +F + +I V+G + Sbjct: 80 DSAKMQQQKERAVKGLTGGVEYLFKKNKVTYYKGEGSF--ETAHSIRVNGLDGKQEMLET 137 Query: 194 PHILIATGG----MPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGI 249 +IATG +P P + ++ ++S G L +P V++G G I +E+ + Sbjct: 138 KKTIIATGSEPTELPFLPFDEKVV-----LSSTGALALPRVPKTMVVIGGGVIGLELGSV 192 Query: 250 LSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF-SQVKEVKKTLSGLEVS 308 + LG++ +++ + + D ++ L A E +KF + K V T +G VS Sbjct: 193 WARLGAEVTVVEFAPRCAPTLDEDVTNALVGAL--AKNEKMKFMTSTKVVGGTNNGDSVS 250 Query: 309 M-VTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNV 367 + V G+ +T + LL ++GR P T L L+K+ + +++G + + + T++ Sbjct: 251 LEVEGKNGKRETVT----CEALLVSVGRRPFTGGLGLDKINVAKNERGFVKIGDHFETSI 306 Query: 368 KGIYAVGDVCGKA-LLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGL 426 +YA+GDV K +L A G A L + ++Y IP V+++ P + +VG Sbjct: 307 PDVYAIGDVVDKGPMLAHKAEDEGVACAEIL--AGKPGHVNYGVIPAVIYTMPEVASVGK 364 Query: 427 TEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDE 486 +EDE + K G+ K F A +K++ ++++G+H+ E Sbjct: 365 SEDE-LKKEGVA-YKVGKFPFNANSRAKAVSTEDGFVKVLVDKATDRILGVHIVCTTAGE 422 Query: 487 MLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 ++ +A++ GA+ D T HPT SE L Sbjct: 423 LIGEACLAMEYGASSEDVGRTCHAHPTMSEAL 454 >3Q6J-A nrPDB Length = 523 Score = 113 bits (282), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 126/487 (25%), Positives = 209/487 (42%), Gaps = 43/487 (8%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKKVMWNTAVHSEF 122 YD + IGGG+ G + +G R +V+ LGG+C + CVP + + A Sbjct: 43 EYDAIFIGGGAAGRFGSAYLRAMGGRQLIVDRWPFLGGSCPHNACVPHHLFSDCAAELML 102 Query: 123 MHDHA-DYGFPSCEGKFNWRVIKEKRDAYVSRLNAIY--QNNLTKS--HIEIIRGHAAFT 177 + Y FP K IKE D + + N + N +K ++E I A Sbjct: 103 ARTFSGQYWFPDMTEKVVG--IKEVVDLFRAGRNGPHGIMNFQSKEQLNLEYILNCPAKV 160 Query: 178 SDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEEL---PGRS 234 D T+E +GK + A ++++A G P T +PG + D +EEL PG + Sbjct: 161 ID-NHTVEAAGKVFKAKNLILAVGAGPGT---LDVPGVNAKGVFDHATLVEELDYEPGST 216 Query: 235 VIV-GAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFS 293 V+V G AVE +A G +T +++R + + D+ + ++ G+E++ S Sbjct: 217 VVVVGGSKTAVEYGCFFNATGRRTVMLVRTEPLKLIKDNETRAYVLDRMKEQGMEIISGS 276 Query: 294 QVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDD 353 V +++ +G V AV P M + D + +G P + +L+ LG+ Sbjct: 277 NVTRIEEDANG----RVQAVVAMTPNGEMRIETDFVFLGLGEQPRSAELA-KILGLDLGP 331 Query: 354 KGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYN--NI 411 KG ++V+E+ T+V +YAVGD+ G P+ + RK K+ Y N Sbjct: 332 KGEVLVNEYLQTSVPNVYAVGDLIGG----PMEMFKARKSGCYAARNVMGEKISYTPKNY 387 Query: 412 PTVVFSHPPIGTVGLTEDEA-IHKYGIENVK-----------TYSTSFTPMYHAVTKRKT 459 P + +H + +G+ E+EA + I +K S M +A K Sbjct: 388 PDFLHTHYEVSFLGMGEEEARAAGHEIVTIKMPPDTENGLNVALPASDRTMLYAFGKGTA 447 Query: 460 KC--VMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNT--VAIHPTSS 515 K+V K KV+G H G G + Q V +K G T + + + ++PT Sbjct: 448 HMSGFQKIVIDAKTRKVLGAHHVGYGAKDAFQYLNVLIKQGLTVDELGDMDELFLNPTHF 507 Query: 516 EELVTLR 522 +L LR Sbjct: 508 IQLSRLR 514 >1XDI-A nrPDB Length = 499 Score = 103 bits (256), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 115/466 (24%), Positives = 189/466 (40%), Gaps = 35/466 (7%) Query: 68 LVIGGGSGGLASARRAAEL---GARAAVVESHKLGGTCVNVGCVPKKV-MWNTAVHSEFM 123 +++GGG G +A AA + V++ +GG V CVP K + +T + +E Sbjct: 6 VILGGGPAGYEAALVAATSHPETTQVTVIDCDGIGGAAVLDDCVPSKTFIASTGLRTELR 65 Query: 124 HD-HADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKP 182 H + + K + I + + +A L +++I G D P Sbjct: 66 RAPHLGFHIDFDDAKISLPQIHARVKTLAAAQSADITAQLLSMGVQVIAGRGELI-DSTP 124 Query: 183 TI----------EVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPG 232 + + S ++ A +L+ATG P +Q G + +T + L+ LP Sbjct: 125 GLARHRIKATAADGSTSEHEADVVLVATGASPRILPSAQPDGERI-LTWRQLYDLDALPD 183 Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF 292 ++VG+G E + LG +++ D VL D+ + E GV + K Sbjct: 184 HLIVVGSGVTGAEFVDAYTELGVPVTVVASQDHVLPYEDADAALVLEESFAERGVRLFKN 243 Query: 293 SQVKEVKKTLSGLEVSMVTA--VPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQ 350 ++ V +T +G+ V+M V G +MT IG VPNT L L ++GIQ Sbjct: 244 ARAASVTRTGAGVLVTMTDGRTVEGSHALMT-----------IGSVPNTSGLGLERVGIQ 292 Query: 351 TDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGR-KLAHRLFEYKEDSKLDYN 409 ++ VD T GIYA GD G L VA GR + H L E S + Sbjct: 293 LGRGNYLTVDRVSRTLATGIYAAGDCTGLLPLASVAAMQGRIAMYHALGEGV--SPIRLR 350 Query: 410 NIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCAN 469 + VF+ P I VG+ +++ G +T A +K+ C Sbjct: 351 TVAATVFTRPEIAAVGVP--QSVIDAGSVAARTIMLPLRTNARAKMSEMRHGFVKIFCRR 408 Query: 470 KEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSS 515 V+G + E++ AVAV+ T + T+A++P+ S Sbjct: 409 STGVVIGGVVVAPIASELILPIAVAVQNRITVNELAQTLAVYPSLS 454 >3L8K-A nrPDB Length = 466 Score = 96.3 bits (238), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 107/442 (24%), Positives = 197/442 (44%), Gaps = 53/442 (11%) Query: 97 KLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNA 156 +LGG C+ GCVP K + + + + A+ P ++ +++++D YV L Sbjct: 38 ELGGNCLYSGCVPSKTVREVIQTAWRLTNIANVKIP-----LDFSTVQDRKD-YVQELR- 90 Query: 157 IYQNNLTKSHIEIIRGHAAFTSDPKPTIEV----SGKKYTAP--HILIATGGMPSTPHES 210 Q+ S E + + + PT + GK+ A +++IA+G + + Sbjct: 91 FKQHKRNMSQYETLTFYKGYVKIKDPTHVIVKTDEGKEIEAETRYMIIASGAETA---KL 147 Query: 211 QIPGASLGITSDGFF----QLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKV 266 ++PG +TSD F +LP VI+GAGYI +E+A I +G +T ++ D+ Sbjct: 148 RLPGVEYCLTSDDIFGYKTSFRKLPQDMVIIGAGYIGLEIASIFRLMGVQTHIIEMLDRA 207 Query: 267 LRSFDSMISTNCTEELENAGVEVLKF-----SQVKEVKKTLSG-LEVSMVTAVPGRLPVM 320 L + + +++ N + +LK S V EVKK EV T + + Sbjct: 208 LITLED-------QDIVNTLLSILKLNIKFNSPVTEVKKIKDDEYEVIYSTKDGSKKSIF 260 Query: 321 TMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKA 380 T + ++ A GR P + ++G+ G I+VDE TN+ ++A GD G A Sbjct: 261 T-----NSVVLAAGRRPVIPE-GAREIGLSISKTG-IVVDETMKTNIPNVFATGDANGLA 313 Query: 381 LLTPVAI-----AAGRKLAHRL-FEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHK 434 A+ AA +A+ + +Y +D +IP +++ P + VG+ +A K Sbjct: 314 PYYHAAVRMSIAAANNIMANGMPVDY-----VDVKSIPVTIYTIPSLSYVGILPSKA-RK 367 Query: 435 YGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVA 494 GIE V+ + + +K + V+K++ +++G M G+ ++ +A Sbjct: 368 MGIEIVEAEYNMEEDVSAQIYGQK-EGVLKLIFERGSMRLIGAWMIGVHSQYLINELGLA 426 Query: 495 VKMGATKADFDNTVAIHPTSSE 516 V G + HP+++E Sbjct: 427 VAYGLNAKQLASFAEQHPSTNE 448 >3IC9-A nrPDB Length = 492 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 110/447 (24%), Positives = 177/447 (39%), Gaps = 57/447 (12%) Query: 62 VASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSE 121 V + D +IG G+ G+ + R A + + ++E G TC VGC+P K++ A S Sbjct: 6 VINVDVAIIGTGTAGMGAYRAAKKHTDKVVLIEGGAYGTTCARVGCMPSKLLIAAADASY 65 Query: 122 FMHDHADYGFP----SCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFT 177 +G S GK + I+ +RD +V + ++ + + IRG A F Sbjct: 66 HASQTDLFGIQVDRISVNGKAVMKRIQTERDRFVG---FVVESVESFDEQDKIRGFAKFL 122 Query: 178 SDPKPTIEVSG-KKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVI 236 + T++V + A I+IATG P+ P G+ L +T+D F+L +LP + Sbjct: 123 DE--HTLQVDDHSQVIAKRIVIATGSRPNYPEFLAAAGSRL-LTNDNLFELNDLPKSVAV 179 Query: 237 VGAGYIAVEMAGILSALGSKTSLMIR-------HDKVLRS-----------FDSMISTNC 278 G G I +E+ LS LG + R D+ ++ FD+ Sbjct: 180 FGPGVIGLELGQALSRLGVIVKVFGRSGSVANLQDEEMKRYAEKTFNEEFYFDAKARVIS 239 Query: 279 TEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPN 338 T E E+A VEV+ F K +KT + +L A GR N Sbjct: 240 TIEKEDA-VEVIYFD--KSGQKTTESFQ---------------------YVLAATGRKAN 275 Query: 339 TKDLSLNKLGIQTDDKGHIIVDEFQ-NTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRL 397 L L I+ D K + DE T+V I+ GD L A G+ Sbjct: 276 VDKLGLENTSIELDKKNSPLFDELTLQTSVDHIFVAGDANNTLTLLHEAADDGKVAGTNA 335 Query: 398 FEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTY---STSFTPMYHAV 454 Y ++ +VVF+ P + +VGL+ + Y ++ Y SF + Sbjct: 336 GAYPVIAQGQRRAPLSVVFTEPQVASVGLSLRQIEDLYADQDAANYVVGQVSFEGQGRSR 395 Query: 455 TKRKTKCVMKMVCANKEEKVVGIHMQG 481 K K ++ + + +G M G Sbjct: 396 VMGKNKGLLNVYADRTSGEFLGAEMFG 422 >3CGD-A nrPDB Length = 480 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 85/319 (26%), Positives = 129/319 (40%), Gaps = 43/319 (13%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFM 123 S +Y++IGG + G+++A + A VV K G C V+ +E Sbjct: 36 SMNYVIIGGDAAGMSAAMQIVRNDENANVVTLEK-GEIYSYAQCGLPYVISGAIASTE-- 92 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 K R +K RD Y ++A ++ +TK E +A T K Sbjct: 93 -------------KLIARNVKTFRDKY--GIDAKVRHEVTKVDTEKKIVYAEHTK-TKDV 136 Query: 184 IEVSGKKYTAPHILIATGGMPSTPHES--QIPGASLGIT-SDGFFQLEELPGRSV----I 236 E ++ +LIATG P P + G L T D L+ L V I Sbjct: 137 FE-----FSYDRLLIATGVRPVMPEWEGRDLQGVHLLKTIPDAERILKTLETNKVEDVTI 191 Query: 237 VGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVK 296 +G G I +EMA LG K ++ R+D + +D ++ +E + +E+L VK Sbjct: 192 IGGGAIGLEMAETFVELGKKVRMIERNDHIGTIYDGDMAEYIYKEADKHHIEILTNENVK 251 Query: 297 EVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGH 356 K V V G D +L ++G PNT L I+T+ KG Sbjct: 252 AFK---GNERVEAVETDKGTYK-------ADLVLVSVGVKPNTD--FLEGTNIRTNHKGA 299 Query: 357 IIVDEFQNTNVKGIYAVGD 375 I V+ + TNV+ +YA GD Sbjct: 300 IEVNAYMQTNVQDVYAAGD 318 >1YQZ-A nrPDB Length = 438 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 48/182 (26%), Positives = 83/182 (45%), Gaps = 32/182 (17%) Query: 213 PGAS---LGITSDGFFQLEELPG--------------RSVIVGAGYIAVEMAGILSALGS 255 PGAS LG SD F L L + ++VGAGY+++E+ L G Sbjct: 113 PGASANSLGFESDITFTLRNLEDTDAIDQFIKANQVDKVLVVGAGYVSLEVLENLYERGL 172 Query: 256 KTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPG 315 +L+ R DK+ + D+ ++ +EL+ + ++ E ++G E++ + Sbjct: 173 HPTLIHRSDKINKLMDADMNQPILDELDKREIPY----RLNEEINAINGNEITFKSG--- 225 Query: 316 RLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGD 375 + D ++ +G PN+K + I+ D KG I V++ TNV IYA+GD Sbjct: 226 ------KVEHYDMIIEGVGTHPNSK--FIESSNIKLDRKGFIPVNDKFETNVPNIYAIGD 277 Query: 376 VC 377 + Sbjct: 278 IA 279 >4CBQ-A nrPDB Length = 314 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 67/232 (28%), Positives = 108/232 (46%), Gaps = 37/232 (15%) Query: 173 HAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPG--------ASLGITSDG- 223 H F++ P GK+ ++IATG +T +PG S DG Sbjct: 90 HVDFSTQPFKLFTEEGKEVLTKSVIIATG---ATAKRMHVPGEDKYWQNGVSACAICDGA 146 Query: 224 --FFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEE 281 F+ + L ++VG G A+E A L+ GSK ++ R D R+ +M Sbjct: 147 VPIFRNKVL----MVVGGGDAAMEEALHLTKYGSKVIILHRRD-AFRASKTMQE----RV 197 Query: 282 LENAGVEVLKFSQVKEVK---KTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPN 338 L + +EV+ S++ E++ L+G ++ + V G V +P V L +AIG PN Sbjct: 198 LNHPKIEVIWNSELVELEGDGDLLNGAKIHNL--VSGEYKV---VP-VAGLFYAIGHSPN 251 Query: 339 TKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAG 390 +K L ++T D G+I+ E T+V G++A GDVC + + +AAG Sbjct: 252 SKFLGGQ---VKTADDGYILT-EGPKTSVDGVFACGDVCDRVYRQAI-VAAG 298 >3NTA-A nrPDB Length = 574 Score = 51.6 bits (122), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 64/249 (25%), Positives = 107/249 (42%), Gaps = 37/249 (14%) Query: 186 VSGKKYTAPH--ILIATGGMPSTPHESQIPGASLGITS--------DGFFQLEELPG--R 233 + G +Y + +L++ G P P IPG +T D Q ++ Sbjct: 97 LDGSEYQESYDTLLLSPGAAPIVP---PIPGVDNPLTHSLRNIPDMDRILQTIQMNNVEH 153 Query: 234 SVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFS 293 + +VG G+I +EM L LG KT+L+ D+V+ D ++ + + + GV++ + Sbjct: 154 ATVVGGGFIGLEMMESLHHLGIKTTLLELADQVMTPVDREMAGFAHQAIRDQGVDLRLGT 213 Query: 294 QVKEVKKTL-------SGLEVSMVTAVPGRLPVMTM---IPDVDCLLWAIGRVPNTKDLS 343 + EV + + E + + G L + + + D L+ AIG P T+ Sbjct: 214 ALSEVSYQVQTHVASDAAGEDTAHQHIKGHLSLTLSNGELLETDLLIMAIGVRPETQ--L 271 Query: 344 LNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGD-------VCGKALLTPVAIAA---GRKL 393 G+ + G I V+ T+ IYAVGD V G+A L P+A A GR Sbjct: 272 ARDAGLAIGELGGIKVNAMMQTSDPAIYAVGDAVEEQDFVTGQACLVPLAGPANRQGRMA 331 Query: 394 AHRLFEYKE 402 A +F +E Sbjct: 332 ADNMFGREE 340 >2CDU-A nrPDB Length = 452 Score = 51.6 bits (122), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 52/194 (26%), Positives = 85/194 (43%), Gaps = 34/194 (17%) Query: 196 ILIATGGMPSTPHESQIPGASLGIT---SDGFFQLEELPGRSVI--VGAGYIAVEMAGIL 250 +++ TG P+ P I + + + +D EE P I +G+GYI E+A Sbjct: 109 LIMTTGSKPTVPPIPGIDSSRVYLCKNYNDAKKLFEEAPKAKTITIIGSGYIGAELAEAY 168 Query: 251 SALGSKTSLMIRHDKVL-RSFDSMISTNCTEELENAGV------EVLKFSQVKE--VKKT 301 S +L+ H++VL + FD + ++ E GV +V F +V + + KT Sbjct: 169 SNQNYNVNLIDGHERVLYKYFDKEFTDILAKDYEAHGVNLVLGSKVAAFEEVDDEIITKT 228 Query: 302 LSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDE 361 L G E+ D + IG PNT+ L K + D G II DE Sbjct: 229 LDGKEIKS-----------------DIAILCIGFRPNTE---LLKGKVAMLDNGAIITDE 268 Query: 362 FQNTNVKGIYAVGD 375 + +++ + I+A GD Sbjct: 269 YMHSSNRDIFAAGD 282 >3ISH-A nrPDB Length = 311 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 54/196 (27%), Positives = 80/196 (40%), Gaps = 18/196 (9%) Query: 188 GKKYTAPHILIATGGMPS---TPHESQI--PGASLGITSDGFFQLEELPGRSVIVGAGYI 242 GK + A ++IATGG P ES+ G S T DGFF + ++G G Sbjct: 98 GKTFEAKSVIIATGGSPKRTGIKGESEYWGKGVSTCATCDGFFYKNK---EVAVLGGGDT 154 Query: 243 AVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTL 302 AVE A L+ + K L+ R D N +E L V+E+K Sbjct: 155 AVEEAIYLANICKKVYLIHRRDGF-----RCAPITLEHAKNNDKIEFLTPYVVEEIKGDA 209 Query: 303 SGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSL--NKLGIQTDDKGHIIVD 360 SG+ + ++P +G N L N + + D+ G I+VD Sbjct: 210 SGVSSLSIKNTATNEKRELVVPG---FFIFVGYDVNNAVLKQEDNSMLCKCDEYGSIVVD 266 Query: 361 EFQNTNVKGIYAVGDV 376 TNV+G++A GD+ Sbjct: 267 FSMKTNVQGLFAAGDI 282 >5M5J-A nrPDB Length = 325 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 44/153 (28%), Positives = 76/153 (49%), Gaps = 19/153 (12%) Query: 243 AVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVK--- 299 A E A L+ + +K +++R DK R+ +M+ E+L +E++ S + E+K Sbjct: 170 ACEEATYLTKIATKVYMVLRRDK-FRASAAMVKKVMNEKL----IEIIYDSAIDEIKGDG 224 Query: 300 KTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIV 359 K ++ VS+ G+ T + L WA+G P T L +L + D+ G+I++ Sbjct: 225 KCVTS--VSIKNLKDGK----TRTLNAGALYWAVGHDPQTSFLKKGQL--EQDEAGYILL 276 Query: 360 DEF--QNTNVKGIYAVGDVCGKALLTPVAIAAG 390 + Q T+V G++A GD C L +AAG Sbjct: 277 KDHPTQRTSVDGVFAAGDCCDH-LYRQAVVAAG 308 >2Q7V-A nrPDB Length = 325 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 75/322 (23%), Positives = 126/322 (39%), Gaps = 51/322 (15%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFM 123 YD ++IGGG GL +A ++E GG ++ W+ V + Sbjct: 8 DYDVVIIGGGPAGLTAAIYTGRAQLSTLILEKGMPGG----------QIAWSEEVEN--- 54 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRG--HAAFTSDPK 181 FP + ++ + A K ++ ++G H A TS P Sbjct: 55 -------FPGFPEPIAGMELAQRMHQQAEKFGA-------KVEMDEVQGVQHDA-TSHPY 99 Query: 182 P-TIEVSGKKYTAPHILIATGGMP---STPHESQI--PGASLGITSDGFFQLEELPGRSV 235 P T+ +Y A +++ATG P P E G S T DGFF + + V Sbjct: 100 PFTVRGYNGEYRAKAVILATGADPRKLGIPGEDNFWGKGVSTCATCDGFFYKGK---KVV 156 Query: 236 IVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQV 295 ++G G AVE L+ + +++ R D LR+ N ++ + + V Sbjct: 157 VIGGGDAAVEEGMFLTKFADEVTVIHRRD-TLRA----NKVAQARAFANPKMKFIWDTAV 211 Query: 296 KEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKG 355 +E++ S V + G + + D + IG VPNT + K + D G Sbjct: 212 EEIQGADSVSGVKLRNLKTGEVSELA----TDGVFIFIGHVPNT---AFVKDTVSLRDDG 264 Query: 356 HIIVDEFQNTNVKGIYAVGDVC 377 ++ V + TN+ ++A GDV Sbjct: 265 YVDVRDEIYTNIPMLFAAGDVS 286 >4FX9-A nrPDB Length = 453 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 75/316 (23%), Positives = 134/316 (42%), Gaps = 45/316 (14%) Query: 189 KKYTAPHILIATGGMPSTP----------HESQIPGASLGITSDGFFQLEELPGRSVIVG 238 K Y +++ A G P P + +P +L I +E+ +V++ Sbjct: 102 KSYEWDYLVFANGASPQVPAIEGVNLKGVFTADLPPDALAIRE----YMEKYKVENVVII 157 Query: 239 AGY-IAVEMAGILSALGSKTSLMIRHDKVL-RSFDSMISTNCTEELENAGVEVLKFSQVK 296 G I +EMA +A G ++++R ++VL RSFD + T+ EE V + +++ Sbjct: 158 GGGYIGIEMAEAFAAQGKNVTMIVRGERVLRRSFDKEV-TDILEEKLKKHVNL----RLQ 212 Query: 297 EVKKTLSGLE-VSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKG 355 E+ + G E V V G + ++ A G PN + +LG++ + G Sbjct: 213 EITMKIEGEERVEKVVTDAGEY-------KAELVILATGIKPNIE--LAKQLGVRIGETG 263 Query: 356 HIIVDEFQNTNVKGIYAVGDVC-------GKALLTPVAIAAGRKLAHRLFEYKEDSKLDY 408 I +E T+V+ +YA GDV G+ + P+A AG K+ + +L + Sbjct: 264 AIWTNEKMQTSVENVYAAGDVAETRHVITGRRVWVPLA-PAGNKMGYVAGSNIAGKELHF 322 Query: 409 NNI---PTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKM 465 + F IG GLTE EA+ + S P Y+ + + +K Sbjct: 323 PGVLGTAVTKFMDVEIGKTGLTEMEALKEGYDVRTAFIKASTRPHYYPGGR---EIWLKG 379 Query: 466 VCANKEEKVVGIHMQG 481 V N+ +++G+ + G Sbjct: 380 VVDNETNRLLGVQVVG 395 >5UWY-A nrPDB Length = 308 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 89/358 (24%), Positives = 141/358 (39%), Gaps = 74/358 (20%) Query: 63 ASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEF 122 A YD L+IG G G+ +A AA A++E GG M NT Sbjct: 3 AMYDTLIIGSGPAGMTAALYAARSNLSVAIIEQGAPGGQ-----------MNNT------ 45 Query: 123 MHDHADY-GFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSD-- 179 D +Y G+ G L L K ++E I G + Sbjct: 46 -FDIENYPGYDHISG---------------PELAMKMYEPLEKFNVENIYGIVQKIENFG 89 Query: 180 PKPTIEVSGKKYTAPHILIATG------GMPSTPHESQIPGASLGITSDG-FFQLEELPG 232 + Y A ++IATG G+P + + G S DG FF+ ++L Sbjct: 90 DYKCVLTEDASYEAKTVIIATGAKYRVLGVPGEEYYTS-RGVSYCAVCDGAFFRDQDL-- 146 Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHD-----KVLRSFDSMISTNCTEELENAGV 287 ++VG G AVE A L+ K +++ R D K+L+ D + + + + ++ V Sbjct: 147 --LVVGGGDSAVEEAIYLTQFAKKVTVVHRRDQLRAQKILQ--DRAFANDKVDFIWDSVV 202 Query: 288 EVLKFSQVKEVKKTLSGLEVSMVT--AVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLN 345 + ++ + +K + ++ VT A G + M P G V KDL + Sbjct: 203 KEIQGNDIKVSNVLIENVKTGQVTDHAFGGVFIYVGMNP-------VTGMV---KDLEI- 251 Query: 346 KLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKAL-LTPVAIAAGRKLAHRLFEYKE 402 TD +G II D+ T++ GI+A+GDV K L A+ G ++ Y E Sbjct: 252 -----TDSEGWIITDDHMRTSIPGIFAIGDVRQKDLRQITTAVGDGAIAGQGVYHYLE 304 >3F8P-A nrPDB Length = 323 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 54/175 (30%), Positives = 82/175 (46%), Gaps = 18/175 (10%) Query: 236 IVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSM-ISTNCTEELENAGVEVLKFSQ 294 ++G G A+E A ILS+ +K L+ R D +F + I ++ N VE + S Sbjct: 159 VIGGGDSALEGAEILSSYSTKVYLIHRRD----TFKAQPIYVETVKKKPN--VEFVLNSV 212 Query: 295 VKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDK 354 VKE+K +V + G + + +V+ + IG P T N GI+TD Sbjct: 213 VKEIKGDKVVKQVVVENLKTGEIKEL----NVNGVFIEIGFDPPTDFAKSN--GIETDTN 266 Query: 355 GHIIVDEFQNTNVKGIYAVGDVCGKALL----TPVAIAAGRKLAHRLFEYKEDSK 405 G+I VDE+ T+V G++A GD C A L A+A G A + Y + K Sbjct: 267 GYIKVDEWMRTSVPGVFAAGD-CTSAWLGFRQVITAVAQGAVAATSAYRYVTEKK 320 >2BC1-A nrPDB Length = 490 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 43/149 (28%), Positives = 67/149 (44%), Gaps = 24/149 (16%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRS-FDSMISTNCTEELENAGVEVLK 291 R +VGAGYI VE+A G + L+ D L +D ++ + +E G+++ Sbjct: 196 RVAVVGAGYIGVELAEAFQRKGKEVVLIDVVDTCLAGYYDRDLTDLMAKNMEEHGIQLAF 255 Query: 292 FSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIP-----DVDCLLWAIGRVPNTKDLSLNK 346 VKE V G V +I DVD ++ A+G PNT +L Sbjct: 256 GETVKE---------------VAGNGKVEKIITDKNEYDVDMVILAVGFRPNT---TLGN 297 Query: 347 LGIQTDDKGHIIVDEFQNTNVKGIYAVGD 375 I G +V++ Q T++ G+YA+GD Sbjct: 298 GKIDLFRNGAFLVNKRQETSIPGVYAIGD 326 >4ZN0-A nrPDB Length = 311 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 87/351 (24%), Positives = 131/351 (37%), Gaps = 63/351 (17%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 YD ++IGGG GL + A G ++E +++ G V Sbjct: 8 YDLIIIGGGPAGLTAGIYAVRYGLDTLILERNEISGQISMADIVE--------------- 52 Query: 125 DHADY-GFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHI-EIIRGHAAFTSDPKP 182 +Y GFPS G + R Q K+ I E++ + + K Sbjct: 53 ---NYPGFPSISGL-----------ELMERFRTHAQEVGVKTTITEVL---SVRSEGTKK 95 Query: 183 TIEVSGKKYTAPHILIATGGMPS---TPHESQI--PGASLGITSDGFFQLEELPGRSVIV 237 I A ++IATG P P E ++ G S DG F ++ +V Sbjct: 96 IITTDSGDLEAKAVIIATGANPKHLGVPGEKELISKGVSYCAICDGPFFRNKIVA---VV 152 Query: 238 GAGYIAVEMAGILSALGSKTSLMIRHD--KVLRSFDSMISTNCTEELENAGVEVLKFSQV 295 G G AV A LS + K L+ R D K R + +E++ S V Sbjct: 153 GGGNSAVTDALFLSKVAQKVYLVHRRDHLKAARVLQDRVDGT-------PNIELILNSHV 205 Query: 296 KEVKKTLSGL---EVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD 352 E+ T G+ E ++ V R T + + +G PNT+ + + K D Sbjct: 206 LEIVGTREGIKKVEKIILEDVNSR---ETRELSTNGVFIYVGIHPNTEFVDVEK-----D 257 Query: 353 DKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPV-AIAAGRKLAHRLFEYKE 402 + G I D + T+ KGIYA GD + V A+ G A +EY E Sbjct: 258 EGGFIKTDRWMETSEKGIYAAGDCRDTPIWQLVTAVRDGAIAATAAYEYIE 308 >1F6M-A nrPDB Length = 320 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 59/228 (25%), Positives = 98/228 (42%), Gaps = 27/228 (11%) Query: 163 TKSHIEIIRGHAAFTSDPKPTIEVSGK--KYTAPHILIATG------GMPSTPHESQIPG 214 TK EII H ++G +YT ++IATG G+PS + G Sbjct: 73 TKFETEIIFDHINKVDLQNRPFRLNGDNGEYTCDALIIATGASARYLGLPS-EEAFKGRG 131 Query: 215 ASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMI 274 S T DGFF + + ++G G AVE A LS + S+ L+ R D R+ + ++ Sbjct: 132 VSASATCDGFFYRNQ---KVAVIGGGNTAVEEALYLSNIASEVHLIHRRDG-FRA-EKIL 186 Query: 275 STNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIG 334 +++EN + + ++EV G+ + + ++ DV L AIG Sbjct: 187 IKRLMDKVENGNIILHTNRTLEEVTGDQMGVTGVRLRDTQNSDNIESL--DVAGLFVAIG 244 Query: 335 RVPNTK------DLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDV 376 PNT +L + +Q+ G+ T++ G++A GDV Sbjct: 245 HSPNTAIFEGQLELENGYIKVQSGIHGNAT-----QTSIPGVFAAGDV 287 >6BWT-A nrPDB Length = 319 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 51/199 (25%), Positives = 85/199 (42%), Gaps = 22/199 (11%) Query: 189 KKYTAPHILIATGGMP-----STPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIA 243 ++YT ++IATG + + G S T DGFF + +VG G A Sbjct: 103 EQYTCDTLIIATGATAKYLGLESEEKFMGKGVSACATCDGFFYKNK---DVAVVGGGNTA 159 Query: 244 VEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLS 303 VE A LS + +L+ R D LRS + ++ E+ ++ + ++ + ++EV Sbjct: 160 VEEALFLSNIAKSVTLIHRRD-TLRS-EKILIDKLMEKAQHGNINIIWNTTLEEVLGDDM 217 Query: 304 GLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD--- 360 G+ + + + V AIG PNT + G + G+I V Sbjct: 218 GVNALRIKNIKTNEESQMGVAGV---FIAIGHTPNTSIFA----GQLEMENGYIKVKSGL 270 Query: 361 --EFQNTNVKGIYAVGDVC 377 + TN+KG++A GDV Sbjct: 271 AGDATQTNIKGVFAAGDVA 289 >5JFC-L nrPDB Length = 474 Score = 45.4 bits (106), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 28/85 (32%), Positives = 43/85 (50%), Gaps = 1/85 (1%) Query: 321 TMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKA 380 T I + D + AIG+ PN L G++ D+ G I+VDE T++ G++A GD Sbjct: 391 TFIMEFDTAIIAIGQTPNKTFLETVP-GLKVDEWGRIVVDENLMTSIPGVFAGGDAIRGE 449 Query: 381 LLTPVAIAAGRKLAHRLFEYKEDSK 405 +A+ GRK A + +Y K Sbjct: 450 ATVILAMGDGRKAAKAIHQYLSKEK 474 >4YRY-B nrPDB Length = 468 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 87/367 (23%), Positives = 149/367 (40%), Gaps = 88/367 (23%) Query: 69 VIGGGSGGLASARRAAELGARAAVVES-HKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHA 127 V+G G GL +A A++G + E+ HK GG V Sbjct: 145 VVGSGPAGLTAAADLAKMGYHVDIFEAFHKPGGVLV------------------------ 180 Query: 128 DYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVS 187 YG P E + R++ E+ +Y+ +L + H+ + G T++V Sbjct: 181 -YGIP--EFRLPKRIV-EREVSYIRKLGVNF-------HLNTVVGK---------TVKVK 220 Query: 188 GKKYTAPHILIATGGMPSTPHESQIPGASL-GITSDG------------FFQLEELP--- 231 + I TG TP IPG +L G+ S F + P Sbjct: 221 ELLSEYDAVFIGTGA--GTPKFMGIPGTNLNGVYSANEFLTRVNLMKAYLFPEYDTPIRV 278 Query: 232 GRSV-IVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENA---GV 287 G+ V ++GAG A++ A LG++ + I + + R + EE +A G+ Sbjct: 279 GKKVAVIGAGNTAMDAARSALRLGAE-KVYIVYRRTEREMPAR-----REEYHHALEEGI 332 Query: 288 EVLKFS----QVKEVKKTLSGLEVSMV-------TAVPGRLPV--MTMIPDVDCLLWAIG 334 E L + + + + +E + + P +P+ + +VD ++ AIG Sbjct: 333 EFLWLTLPIRYIGDANGNVEAMECVRMELKEADGSGRPRPVPIEGSNFVLEVDMVIEAIG 392 Query: 335 RVPNTKDLSLNKLGIQTDDKGHIIVDEFQN-TNVKGIYAVGDVCGKALLTPVAIAAGRKL 393 + PN LS G++ +++G+I DE T+VKG++A GD+ A A+ AG+K Sbjct: 393 QGPNRVLLS-EFPGLELNERGYIKADEDTGATSVKGVFAGGDIVTGAATVIKAMGAGKKA 451 Query: 394 AHRLFEY 400 A + Y Sbjct: 452 AQFIHSY 458 >4GCM-A nrPDB Length = 312 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 83/350 (23%), Positives = 134/350 (38%), Gaps = 60/350 (17%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVN---VGCVPKKVMWNTAVHS 120 +D +IG G G+ +A A+ + ++E GG N V P M S Sbjct: 6 DFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLS 65 Query: 121 EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP 180 M +HA + A+YQ KS + + Sbjct: 66 TKMFEHA------------------------KKFGAVYQYGDIKS----VEDKGEY---- 93 Query: 181 KPTIEVSGKKYTAPHILIATGG---MPSTPHESQIPGASLGITS--DG-FFQLEELPGRS 234 I K+ TA ++IATG P E ++ G + + DG FF+ + L Sbjct: 94 -KVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRL---- 148 Query: 235 VIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQ 294 ++G G AVE L+ K +++ R D+ LR+ ++ +N ++ + Sbjct: 149 FVIGGGDSAVEEGTFLTKFADKVTIVHRRDE-LRA-QRILQDRA---FKNDKIDFIWSHT 203 Query: 295 VKEVKKTLSGL-EVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDD 353 +K + + + V++ + G + D + IG P T LGI T+D Sbjct: 204 LKSINEKDGKVGSVTLTSTKDGSEETH----EADGVFIYIGMKPLT--APFKDLGI-TND 256 Query: 354 KGHIIVDEFQNTNVKGIYAVGDVCGKALLTPV-AIAAGRKLAHRLFEYKE 402 G+I+ + T+V GI+A GDV K L V A G A EY E Sbjct: 257 VGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIE 306 >5MJK-A nrPDB Length = 327 Score = 45.1 bits (105), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 61/221 (27%), Positives = 99/221 (44%), Gaps = 28/221 (12%) Query: 190 KYTAPHILIATGGMPSTPHESQIPG--------ASLGITSDG-FFQLEELPGRSVIVGAG 240 ++ I+IATG + + +IPG S DG FF+ +E+ +++G G Sbjct: 120 EFITKSIIIATG---ANHRKLEIPGEEEYGARGVSYCAVCDGAFFRNQEI----LVIGGG 172 Query: 241 YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK 300 AVE A L+ G ++M R DK LR+ + + EE N + + + KK Sbjct: 173 DSAVEEALYLTRFGQSVTIMHRRDK-LRAQEIIQQRAFKEEKINFIWDSVPMEIKGDDKK 231 Query: 301 TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD 360 S + ++ T G + + +G P + +S LGI TD+ G II D Sbjct: 232 IQSVVYKNVKT---GEVTEKAF----GGIFIYVGLDPVAEFVS--DLGI-TDEAGWIITD 281 Query: 361 EFQNTNVKGIYAVGDVCGKALLT-PVAIAAGRKLAHRLFEY 400 + TN+ GI+AVGDV K A+ G + A +++ Sbjct: 282 DHMRTNIPGIFAVGDVRQKDFRQITTAVGDGAQAAQEAYKF 322 >5VJ7-A nrPDB Length = 476 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 35/118 (29%), Positives = 62/118 (52%), Gaps = 7/118 (5%) Query: 283 ENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDL 342 EN V+ +KF ++K +++ S + +V G +T+ + D ++ AIG+ PN K L Sbjct: 360 ENGNVKAVKFEKMKPLEERDSRGKRKIV----GTGEYITV--EADTVIIAIGQTPN-KVL 412 Query: 343 SLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEY 400 ++ D+ G I+VDE T++ G++A GD +A+ GRK A + +Y Sbjct: 413 WRATPELKVDEWGRIVVDENLMTSIPGVFAGGDAIRGEATVILAMGDGRKAAKAIHQY 470 >3LZX-A nrPDB Length = 332 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 76/322 (23%), Positives = 131/322 (40%), Gaps = 51/322 (15%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVNVGCVPKKVMWNTAVHSEFM 123 YD +IGGG GL +A A ++ES +LGG P+K +++ A Sbjct: 8 YDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGGQL--SALYPEKYIYDVA------ 59 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 GFP + +KE ++ Q + +E + A D Sbjct: 60 ------GFPKIRAQELINNLKE-------QMAKFDQTICLEQAVESVEKQA----DGVFK 102 Query: 184 IEVSGKKYTAPHILIATGGMPSTPHE------SQIPGASLGITSDGFFQLEELPGRSV-I 236 + + + + + ++I G P + Q G +L D L++ GR V I Sbjct: 103 LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVD---DLQKFAGRRVAI 159 Query: 237 VGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLK-FSQV 295 +G G AV+ A +L + + S++ R DK R+ + + E L + V VL F Sbjct: 160 LGGGDSAVDWALMLEPIAKEVSIIHRRDK-FRAHE-----HSVENLHASKVNVLTPFVPA 213 Query: 296 KEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKG 355 + + + +E ++ V G I ++D L+ G V + + L I+ K Sbjct: 214 ELIGE--DKIEQLVLEEVKGD---RKEILEIDDLIVNYGFVSSLGPIKNWGLDIE---KN 265 Query: 356 HIIVDEFQNTNVKGIYAVGDVC 377 I+V TN++G +A GD+C Sbjct: 266 SIVVKSTMETNIEGFFAAGDIC 287 >5JCN-A nrPDB Length = 451 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 42/147 (28%), Positives = 70/147 (47%), Gaps = 12/147 (8%) Query: 232 GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVL-RSFDSMISTNCTEELENAGVEVL 290 G++VIVG GYI +E++ L +++ + R F + I+ N GV+++ Sbjct: 181 GKAVIVGGGYIGLELSAALKINDFDVTMVFPEPWCMPRLFTADIAAFYESYYTNKGVKIV 240 Query: 291 KFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQ 350 K + +G +V+ V G + + D ++ +G P T +L K G Sbjct: 241 KGTVAVGFDADANG-DVTAVNLKNGS------VLEADIVVVGVGGRPLT---TLFK-GQV 289 Query: 351 TDDKGHIIVDEFQNTNVKGIYAVGDVC 377 ++KG I D F T+V G+YAVGDV Sbjct: 290 AEEKGGIKTDAFFETSVPGVYAVGDVA 316 >1Q1R-A nrPDB Length = 431 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 93/220 (42%), Gaps = 32/220 (14%) Query: 175 AFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGI-TSDGFFQLEELP-- 231 A D + I G+ +++ATGG P +P AS + ++ F L L Sbjct: 85 AINRDRQQVILSDGRALDYDRLVLATGGRPRP-----LPVASGAVGKANNFRYLRTLEDA 139 Query: 232 ----------GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEE 281 R V++G GYI +E+A +L+ +VL + + E Sbjct: 140 ECIRRQLIADNRLVVIGGGYIGLEVAATAIKANMHVTLLDTAARVLERVTAPPVSAFYEH 199 Query: 282 L-ENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPG-RLPVMTMIPDVDCLLWAIGRVPNT 339 L AGV++ +QV + + +V+ V G RLP D ++ IG +PN Sbjct: 200 LHREAGVDIRTGTQVCGFEMSTDQQKVTAVLCEDGTRLP-------ADLVIAGIGLIPNC 252 Query: 340 KDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGK 379 + S G+Q D+ I+++E T+ I AVGD C + Sbjct: 253 ELAS--AAGLQVDNG--IVINEHMQTSDPLIMAVGD-CAR 287 >3IWA-A nrPDB Length = 472 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/169 (28%), Positives = 77/169 (45%), Gaps = 20/169 (11%) Query: 233 RSVIVGAGYIAVEMAGILSAL-GSKTSLMIRHDKVLRSFDSM-ISTNCTEELENAGVEVL 290 ++VIVG G+I +EMA L+ + G T+++ D+++ F S +S +LE V V Sbjct: 161 KAVIVGGGFIGLEMAVSLADMWGIDTTVVELADQIMPGFTSKSLSQMLRHDLEKNDVVVH 220 Query: 291 KFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQ 350 +V L G + + + + D D ++ A G PNT+ G++ Sbjct: 221 TGEKVVR----LEGENGKVARVITDKRTL-----DADLVILAAGVSPNTQ--LARDAGLE 269 Query: 351 TDDKGHIIVDEFQNTNVKGIYAVGD-------VCGKALLTPVAIAAGRK 392 D +G IIVD T+ I+A GD V GK P+ A R+ Sbjct: 270 LDPRGAIIVDTRMRTSDPDIFAGGDCVTIPNLVTGKPGFFPLGSMANRQ 318 >1VDC-A nrPDB Length = 333 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 46/150 (30%), Positives = 69/150 (46%), Gaps = 20/150 (13%) Query: 236 IVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQV 295 ++G G A+E A L+ GSK ++ R D R+ M L N ++V+ S V Sbjct: 164 VIGGGDSAMEEANFLTKYGSKVYIIHRRD-AFRASKIMQQ----RALSNPKIDVIWNSSV 218 Query: 296 KEV-----KKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQ 350 E + L GL+V V V G + + V L +AIG P TK L G++ Sbjct: 219 VEAYGDGERDVLGGLKVKNV--VTGDVSDLK----VSGLFFAIGHEPATKFLD---GGVE 269 Query: 351 TDDKGHIIVDE-FQNTNVKGIYAVGDVCGK 379 D G+++ T+V G++A GDV K Sbjct: 270 LDSDGYVVTKPGTTQTSVPGVFAAGDVQDK 299 >5ER0-A nrPDB Length = 518 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 36/144 (25%), Positives = 65/144 (45%), Gaps = 14/144 (9%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVL-RSFDSMISTNCTEELENAGVEVLK 291 R ++GAGYI E+A S G +L+ +V+ + FD+ + ++ + GV++ Sbjct: 199 RITVIGAGYIGAELAEAYSTTGHDVTLIDAMARVMPKYFDADFTDVIEQDYRDHGVQLAL 258 Query: 292 FSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQT 351 V+ + +GL + + D + IG PNT DL K+ + Sbjct: 259 GETVESFTDSATGLTIKTDKNS----------YETDLAILCIGFRPNT-DLLKGKVDMAP 307 Query: 352 DDKGHIIVDEFQNTNVKGIYAVGD 375 + G II D++ ++ I+A GD Sbjct: 308 N--GAIITDDYMRSSNPDIFAAGD 329 >5W4C-A nrPDB Length = 371 Score = 41.6 bits (96), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 45/149 (30%), Positives = 70/149 (46%), Gaps = 20/149 (13%) Query: 236 IVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQV 295 ++G G A E A L+ GS +++R D++ S +++ T + V VL + Sbjct: 187 VIGGGDSAAEEATYLTKYGSHVYVLVRRDELRAS--KIMAKRLT---SHPKVTVLWNTVA 241 Query: 296 KEVK---KTLSGLEV-SMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQT 351 E K + L+ L + + T G LP V+ L +AIG P T SL K ++ Sbjct: 242 TEAKGDGEVLTSLTIKNTKTGETGDLP-------VNGLFYAIGHEPAT---SLVKSQVEL 291 Query: 352 DDKGHI-IVDEFQNTNVKGIYAVGDVCGK 379 D G+I V T+V G++A GDV K Sbjct: 292 DSDGYIKTVPGTSQTSVHGVFAAGDVQDK 320 >5UTH-A nrPDB Length = 319 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 70/320 (21%), Positives = 130/320 (40%), Gaps = 52/320 (16%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 +D ++IG G G +A AA + V E + GG +M T V + Sbjct: 16 HDVIIIGSGPAGYTAAIYAARAQLKPLVFEGTQFGGA----------LMTTTEVEN---- 61 Query: 125 DHADYGFPSC-EGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 +P EG ++ + R+ + R A +L ++ ++ P T Sbjct: 62 ------YPGFREGITGPELMDQMREQAL-RFGA----DLRMEDVDAVQ-----LEGPVKT 105 Query: 184 IEVSGKKYTAPHILIATGGMP---STPHESQIPGASLGI--TSDGFFQLEELPGRSVIVG 238 + V + + A +++A G P E + G + T DGFF ++ V+VG Sbjct: 106 VVVGDETHQARAVILAMGAAARHLGVPGEEALTGMGVSTCATCDGFFFRDQ---DIVVVG 162 Query: 239 AGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEV 298 G A+E A L+ +L+ R D+ R+ M+ N + L +++ ++ Sbjct: 163 GGDSAMEEATFLTRFARSVTLIHRRDE-FRASKIMLE----RARANEKITFLTNTEITQI 217 Query: 299 KKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHII 358 + V + V G + DV + AIG P ++ L + ++ DD+G++ Sbjct: 218 EGDPKVTGVRLRDTVTGEESKL----DVTGVFVAIGHDPRSE---LVRGQVELDDEGYVK 270 Query: 359 VD-EFQNTNVKGIYAVGDVC 377 V T++ G++A GD+ Sbjct: 271 VQGRTTYTSLDGVFAAGDLV 290 >5YGQ-A nrPDB Length = 342 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 78/348 (22%), Positives = 139/348 (39%), Gaps = 51/348 (14%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVES-HKLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 D L++G G GL + L +A +V+ K+GG C + P+K +++ Sbjct: 8 DVLIVGAGPCGLFAVFELGLLDVKAHLVDILDKVGGQCAEL--YPEKPIYDIP------- 58 Query: 125 DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTI 184 G P G + E+ + N + + ++E I DP + Sbjct: 59 -----GIPMVTGHGLTEALMEQ----IKPFNPTFHLSEMVENVEKI-------GDPGFRV 102 Query: 185 EVS-GKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFF---QLEELPGRSV-IVGA 239 + GK + +++A GG P +PG + + ++E+ G+ + IVG Sbjct: 103 TTNAGKVFECTVLVVAAGGGSFLPKRPPVPGVEAYEGTSVHYAVRKMEDFRGKDILIVGG 162 Query: 240 GYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVK 299 G A++ L+ + +L+ R D + S+ +L +G LK Q+ E++ Sbjct: 163 GDSALDWTLNLNPIAKSMTLVHRRDDFRGAPHSV---EQMRQLVASGKLDLKIGQITELQ 219 Query: 300 K---TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTK-DLSLNKLGIQTDDKG 355 L+G V + ++ M+P L +G V N DL N + + T Sbjct: 220 GDNGQLTGATVKLNDNTTSQIKCDAMLPFFG-LTMKLGPVANWGLDLENNLIPVDTG--- 275 Query: 356 HIIVDEFQNTNVKGIYAVGDVC---GKALLTPVAIAAGRKLAHRLFEY 400 F+ TNV GI+A+GD+ GK L G +A + +Y Sbjct: 276 -----TFE-TNVPGIFAIGDINTYPGKLKLILSGFHEGALMAQKAVKY 317 >3D8X-A nrPDB Length = 326 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 46/145 (31%), Positives = 69/145 (47%), Gaps = 18/145 (12%) Query: 236 IVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQV 295 ++G G A E A L+ GSK +++R D LR+ S I E +N +E+L + Sbjct: 166 VIGGGDSACEEAQFLTKYGSKVFMLVRKDH-LRA--STIMQKRAE--KNEKIEILYNTVA 220 Query: 296 KEVK---KTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD 352 E K K L+ L + + T +P V L +AIG P TK ++ + TD Sbjct: 221 LEAKGDGKLLNALRIKNT-----KKNEETDLP-VSGLFYAIGHTPATKIVAGQ---VDTD 271 Query: 353 DKGHI-IVDEFQNTNVKGIYAVGDV 376 + G+I V T+V G +A GDV Sbjct: 272 EAGYIKTVPGSSLTSVPGFFAAGDV 296 >6BPY-A nrPDB Length = 374 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 43/156 (27%), Positives = 67/156 (42%), Gaps = 31/156 (19%) Query: 236 IVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMIST-----NCTEELENAGVEVL 290 ++G G A E A L+ GS ++++R DK LR+ +M T EVL Sbjct: 163 VIGGGDSAAEEAMFLAKYGSSVTVLVRRDK-LRASKAMAKRLLAHPKVTVRFNTVATEVL 221 Query: 291 KFSQVK------EVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSL 344 + +K T++G E I D + L +A+G P T +L Sbjct: 222 GEKKPNGLMTHLRIKNTVTGEE---------------EIVDANGLFYAVGHDPAT---AL 263 Query: 345 NKLGIQTDDKGHIIVDEFQN-TNVKGIYAVGDVCGK 379 K I D+ G+II + T+ +G++A GDV K Sbjct: 264 VKGQIDLDEDGYIITKPGTSYTSREGVFACGDVQDK 299 >3ICS-A nrPDB Length = 588 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 48/173 (27%), Positives = 81/173 (46%), Gaps = 22/173 (12%) Query: 228 EELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGV 287 E+ P + ++G G+I VEM L G + +L+ ++V+ D ++ E ++N V Sbjct: 184 EKKPRHATVIGGGFIGVEMVENLRERGIEVTLVEMANQVMPPIDYEMAAYVHEHMKNHDV 243 Query: 288 EVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNK- 346 E++ V +++ +G V RL ++I D L+ AIG P + SL K Sbjct: 244 ELVFEDGVDALEE--NGAVV--------RLKSGSVI-QTDMLILAIGVQPES---SLAKG 289 Query: 347 LGIQTDDKGHIIVDEFQNTNVKGIYAVGD-------VCGKALLTPVAIAAGRK 392 G+ +G I V+E T+ IYA+GD V + P+A A R+ Sbjct: 290 AGLALGVRGTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIPLAWPANRQ 342 >5U63-A nrPDB Length = 321 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 54/204 (26%), Positives = 90/204 (44%), Gaps = 34/204 (16%) Query: 189 KKYTAPHILIATG------GMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYI 242 + +T ++IATG G+PS + + G S T DGFF + G ++G G Sbjct: 105 QNFTCDALIIATGASARYIGLPSEEN-YKGRGVSACATCDGFFYRNKPVG---VIGGGNT 160 Query: 243 AVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTL 302 AVE A L+ + S L+ R D R+ + ++ +++E + + + EV Sbjct: 161 AVEEALYLANIASTVHLIHRRDS-FRA-EKILIDRLYKKVEEGKIVLHTDRTLDEVLGDN 218 Query: 303 SGLE-VSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTK----DLSLNKLGIQTDDKGHI 357 G+ + + G + + D L AIG PNT+ L LN G+I Sbjct: 219 MGVTGLRLANTKTGEKEELKL----DGLFVAIGHSPNTEIFQGQLELN--------NGYI 266 Query: 358 IVDEFQN-----TNVKGIYAVGDV 376 +V + T+V+G++A GDV Sbjct: 267 VVKSGLDGNATATSVEGVFAAGDV 290 >4YKF-A nrPDB Length = 521 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 50/177 (28%), Positives = 83/177 (46%), Gaps = 28/177 (15%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLM-----IRHDKVLRSFDSMISTNCTEELENAGV 287 R ++G G VE A L+ + +L+ ++ D+VL+ D + S L+N V Sbjct: 357 RVAVIGGGNSGVEAAIDLAGIVEHVTLLEFAPEMKADQVLQ--DKLRS------LKN--V 406 Query: 288 EVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDC--LLWAIGRVPNTKDLSLN 345 +++ +Q EVK + S V + R V I +++ + IG +PNT L Sbjct: 407 DIILNAQTTEVKG-----DGSKVVGLEYRDRVSGDIHNIELAGIFVQIGLLPNTNWL--- 458 Query: 346 KLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGR--KLAHRLFEY 400 + ++ + G II+D TNVKG++A GD C + IA G K + F+Y Sbjct: 459 EGAVERNRMGEIIIDAKCETNVKGVFAAGD-CTTVPYKQIIIATGEGAKASLSAFDY 514 >1FL2-A nrPDB Length = 310 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 64/229 (27%), Positives = 103/229 (44%), Gaps = 38/229 (16%) Query: 187 SGKKYTAPHILIATGGM---PSTPHESQ--IPGASLGITSDG-FFQLEELPGRSVIVGAG 240 SG A I++ATG + P E Q G + DG F+ + R ++G G Sbjct: 98 SGAVLKARSIIVATGAKWRNMNVPGEDQYRTKGVTYCPHCDGPLFKGK----RVAVIGGG 153 Query: 241 YIAVEMAGILSALGSKTSLM-----IRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQV 295 VE A L+ + +L+ ++ D+VL+ D + S L+N V+++ +Q Sbjct: 154 NSGVEAAIDLAGIVEHVTLLEFAPEMKADQVLQ--DKLRS------LKN--VDIILNAQT 203 Query: 296 KEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDC--LLWAIGRVPNTKDLSLNKLGIQTDD 353 EVK + S V + R V I +++ + IG +PNT L + ++ + Sbjct: 204 TEVKG-----DGSKVVGLEYRDRVSGDIHNIELAGIFVQIGLLPNTNWL---EGAVERNR 255 Query: 354 KGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGR--KLAHRLFEY 400 G II+D TNVKG++A GD C + IA G K + F+Y Sbjct: 256 MGEIIIDAKCETNVKGVFAAGD-CTTVPYKQIIIATGEGAKASLSAFDY 303 >2A87-A nrPDB Length = 335 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 75/332 (22%), Positives = 121/332 (36%), Gaps = 55/332 (16%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHD 125 D +VIG G G +A AA V E GG +M T V + Sbjct: 16 DVIVIGSGPAGYTAALYAARAQLAPLVFEGTSFGG----------ALMTTTDVEN----- 60 Query: 126 HADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIE 185 +P + ++ R A +L +E + H K + Sbjct: 61 -----YPGFRNGITGPELMDEMREQALRFGA----DLRMEDVESVSLHGPL----KSVVT 107 Query: 186 VSGKKYTAPHILIATGGMP---STPHESQI--PGASLGITSDGFFQLEELPGRSVIVGAG 240 G+ + A +++A G P E ++ G S T DGFF ++ ++G G Sbjct: 108 ADGQTHRARAVILAMGAAARYLQVPGEQELLGRGVSSCATCDGFFFRDQ---DIAVIGGG 164 Query: 241 YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEV-- 298 A+E A L+ +L+ R D+ R+ M+ N + L V V Sbjct: 165 DSAMEEATFLTRFARSVTLVHRRDE-FRASKIMLD----RARNNDKIRFLTNHTVVAVDG 219 Query: 299 KKTLSGLEV-SMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHI 357 T++GL V T LPV + AIG P + L + I D G++ Sbjct: 220 DTTVTGLRVRDTNTGAETTLPVT-------GVFVAIGHEPRS---GLVREAIDVDPDGYV 269 Query: 358 IVD-EFQNTNVKGIYAVGDVCGKALLTPVAIA 388 +V +T++ G++A GD+ + V A Sbjct: 270 LVQGRTTSTSLPGVFAAGDLVDRTYRQAVTAA 301 >1NHQ-A nrPDB Length = 447 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 38/144 (26%), Positives = 64/144 (44%), Gaps = 14/144 (9%) Query: 235 VIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSF-DSMISTNCTEELENAGVEVLKFS 293 V++G+GYI +E A + G K +++ D+ L + D + TEE+E + + Sbjct: 153 VVIGSGYIGIEAAEAFAKAGKKVTVIDILDRPLGVYLDKEFTDVLTEEMEANNITIATGE 212 Query: 294 QVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDD 353 V+ + G +VT D D ++ A+G PNT L K ++ Sbjct: 213 TVERYEG--DGRVQKVVTDKNAY--------DADLVVVAVGVRPNTAWL---KGTLELHP 259 Query: 354 KGHIIVDEFQNTNVKGIYAVGDVC 377 G I DE+ T+ ++AVGD Sbjct: 260 NGLIKTDEYMRTSEPDVFAVGDAT 283 >6GAR-A nrPDB Length = 349 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 72/327 (22%), Positives = 134/327 (40%), Gaps = 55/327 (16%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVNVGCVPKKVMWNTAVHSEFM 123 +D VIGGG GL SA + R ++E H LGG + P+K++W+ Sbjct: 7 FDVTVIGGGPAGLYSAFYSGLREMRTKIIEFHPHLGG---KIHVYPEKMIWDVG------ 57 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLT-------KSHIE-IIRGHAA 175 G G D + +L Q LT + +E IIR Sbjct: 58 ------GLLPVTG-----------DKLIEQL---VQQGLTFKPEVVLDTKVESIIR---- 93 Query: 176 FTSDPKPTIEVS-GKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFF---QLEELP 231 D T++ S G+++ + +++ATG P + I GA S+ + L+ Sbjct: 94 -NQDGTFTLKTSTGEEHFSKTVIVATGSGILKPQKLSIEGAERFEVSNLNYTVKSLKRFK 152 Query: 232 GRSVIV-GAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVL 290 G++VI+ G G AV+ A L + K + R ++ L ++ + ++L N+ E Sbjct: 153 GKTVIISGGGNSAVDWANELEPIAKKVYVTYRKEE-LSGHEAQV-----KQLMNSSAECF 206 Query: 291 KFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQ 350 + + ++ + + V ++ +P +D ++ G + L ++L + Sbjct: 207 FNTSITKLIAGDNHEAIEYVELTNHETGEVSHLP-IDEVIINHGYERDITLLENSELDVA 265 Query: 351 TDDKGHIIVDEFQNTNVKGIYAVGDVC 377 D +I + ++V G+YA GD+ Sbjct: 266 IIDNYYIAGNANSESSVDGLYAAGDIL 292 >3LXD-A nrPDB Length = 415 Score = 38.1 bits (87), Expect = 0.010, Method: Compositional matrix adjust. Identities = 40/156 (25%), Positives = 71/156 (45%), Gaps = 13/156 (8%) Query: 226 QLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVL-RSFDSMISTNCTEELEN 284 +L+ +V++G GYI +E A +L+ G +L+ +VL R +S E Sbjct: 147 ELDAGAKNAVVIGGGYIGLEAAAVLTKFGVNVTLLEALPRVLARVAGEALSEFYQAEHRA 206 Query: 285 AGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSL 344 GV++ + + ++ G +V+ V R+ ++IP D ++ IG VP L Sbjct: 207 HGVDLRTGAAMDCIEG--DGTKVTGV-----RMQDGSVIP-ADIVIVGIGIVPCVGAL-- 256 Query: 345 NKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKA 380 + + VDEF T++ +YA+GD A Sbjct: 257 --ISAGASGGNGVDVDEFCRTSLTDVYAIGDCAAHA 290 >6GAS-A nrPDB Length = 331 Score = 37.0 bits (84), Expect = 0.023, Method: Compositional matrix adjust. Identities = 67/324 (20%), Positives = 128/324 (39%), Gaps = 55/324 (16%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVNVGCVPKKVMWNTAVHSEFM 123 YD +IGGG GL +A A ++ES +LGG P+K +++ A Sbjct: 10 YDITIIGGGPTGLFTAFYGGMRQASVKIIESLPQLGGQLS--ALYPEKYIYDVA------ 61 Query: 124 HDHADYGFPSCEGKFNWRVIKE---KRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP 180 GFP + +KE K D V A+ + L K I + Sbjct: 62 ------GFPKVRAQELVDNLKEQMKKFDPTVCLEEAV--DTLEKQADGIFK--------- 104 Query: 181 KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPG----RSVI 236 + + + + + ++I G P ++ G + + + ++++ R V+ Sbjct: 105 ---LVTNKQTHYSKSVIITAGNGAFQPRRLELEGTAKYEKKNLHYFVDDMNKFAGKRVVV 161 Query: 237 VGAGYIAVEMAGILSALGSKTSLMIRHDKVL---RSFDSMISTNCTEELENAGVEVLKFS 293 G G AV+ +L + K +++ R DK S ++++++ VE++ Sbjct: 162 FGGGDSAVDWTMMLEPIAEKVTIVHRRDKFRAHEHSVENLMNSRAEVSTPYVPVELIGDD 221 Query: 294 QVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDD 353 ++++V + V + + + + ++G + N L IQ Sbjct: 222 KIEQVV-------LQHVKTEEKVIIDVDDVIVNYGFVSSLGPIKNWG------LDIQ--- 265 Query: 354 KGHIIVDEFQNTNVKGIYAVGDVC 377 K I+V+ TN+ GIYA GD+C Sbjct: 266 KNSILVNSKMETNIPGIYAAGDIC 289 >3R9U-A nrPDB Length = 315 Score = 36.6 bits (83), Expect = 0.027, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 90/209 (43%), Gaps = 22/209 (10%) Query: 177 TSDPKPTIEVSG-KKYTAPHILIATGGMPSTP-----HESQIPGASLGITSDGFFQLEEL 230 SD TI++ G K A +++ TG P E G S T DGFF + Sbjct: 90 NSDGSFTIKLEGGKTELAKAVIVCTGSAPKKAGFKGEDEFFGKGVSTCATCDGFFYKNK- 148 Query: 231 PGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVL 290 ++G G A+E A L+ + SK L+ R D+ R+ S + + +N +E++ Sbjct: 149 --EVAVLGGGDTALEEALYLANICSKIYLIHRRDE-FRAAPSTVE----KVKKNEKIELI 201 Query: 291 KFSQVKEV---KKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKL 347 + V EV K ++G++V + L V + V L + D +K Sbjct: 202 TSASVDEVYGDKMGVAGVKVKLKDGSIRDLNVPGIFTFVG--LNVRNEILKQDD---SKF 256 Query: 348 GIQTDDKGHIIVDEFQNTNVKGIYAVGDV 376 ++ G + VD T+V G++A GD+ Sbjct: 257 LCNMEEGGQVSVDLKMQTSVAGLFAAGDL 285 >2V3B-A nrPDB Length = 384 Score = 36.2 bits (82), Expect = 0.032, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 88/206 (42%), Gaps = 28/206 (13%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEE-LENAGVEVLK 291 R +++GAG I E A LS+ G + ++ ++V+ + + LE GV Sbjct: 147 RVLLLGAGLIGCEFANDLSSGGYQLDVVAPCEQVMPGLLHPAAAKAVQAGLEGLGVRFHL 206 Query: 292 FSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQT 351 + +KK GLE + +IP D ++ A+G P T+ L + Sbjct: 207 GPVLASLKKAGEGLEAHLSDG--------EVIP-CDLVVSAVGLRPRTELAFAAGLAV-- 255 Query: 352 DDKGHIIVDEFQNTNVKGIYAVGD---VCGKALLTPVAI-AAGRKLAHRLFEYKEDSKLD 407 ++G I+VD T+ IYA+GD V G LL + + A R LA L S++ Sbjct: 256 -NRG-IVVDRSLRTSHANIYALGDCAEVDGLNLLYVMPLMACARALAQTL--AGNPSQVA 311 Query: 408 YNNIPT--------VVFSHPPIGTVG 425 Y +P +V S PP G G Sbjct: 312 YGPMPVTVKTPACPLVVSPPPRGMDG 337 >1XHC-A nrPDB Length = 367 Score = 36.2 bits (82), Expect = 0.032, Method: Compositional matrix adjust. Identities = 57/190 (30%), Positives = 88/190 (46%), Gaps = 36/190 (18%) Query: 196 ILIATGGMPSTPHESQIPGASLGITSDGFFQLE------ELPGRSVIVGAGYIAVEMAGI 249 +++ATG P QI G +T F + E G ++I+G G+I +E+AG Sbjct: 105 LVLATGARAREP---QIKGKEYLLTLRTIFDADRIKESIENSGEAIIIGGGFIGLELAGN 161 Query: 250 LSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK----TLSGL 305 L+ G L+ R L D +S + LE GV+ S++ E + T SG Sbjct: 162 LAEAGYHVKLIHRGAMFL-GLDEELSNMIKDMLEETGVKFFLNSELLEANEEGVLTNSGF 220 Query: 306 EVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNT 365 + G++ + C AIG VPN DL+ + GI T +G +I D F+ T Sbjct: 221 -------IEGKVKI--------C---AIGIVPNV-DLA-RRSGIHT-GRGILIDDNFR-T 258 Query: 366 NVKGIYAVGD 375 + K +YA+GD Sbjct: 259 SAKDVYAIGD 268 >5USX-A nrPDB Length = 319 Score = 35.4 bits (80), Expect = 0.056, Method: Compositional matrix adjust. Identities = 47/172 (27%), Positives = 80/172 (46%), Gaps = 25/172 (14%) Query: 214 GASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSM 273 G S T DGFF + + +VG G AVE A LS + ++ L+ R D R+ + + Sbjct: 132 GVSACATCDGFFYRNQ---KVAVVGGGNTAVEEALYLSNIAAEVHLIHRRDS-FRA-EKI 186 Query: 274 ISTNCTEELENAGVEVLKFSQVKEV---KKTLSGLEVSMV-TAVPGRLPVMTMIPDVDCL 329 + ++++N + + + EV + ++G+ + V T L VM Sbjct: 187 LINRLMDKVQNGNIVLHTDRVLDEVLGDEMGVTGVRLKDVKTGGTEELDVMGA------- 239 Query: 330 LWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD-----EFQNTNVKGIYAVGDV 376 AIG PNT+ + +L ++ G+I+V T+V+GI+A GDV Sbjct: 240 FIAIGHSPNTQ-IFQGQLDMK---DGYILVKSGLEGNATQTSVEGIFAAGDV 287 >4EMJ-A nrPDB Length = 410 Score = 35.0 bits (79), Expect = 0.070, Method: Compositional matrix adjust. Identities = 58/203 (28%), Positives = 84/203 (41%), Gaps = 33/203 (16%) Query: 188 GKKYTAPHILIATGGMPSTPH--ESQIPGASLGITSDGFFQLEEL------PGRSVIVGA 239 G +A I+IATG T SQ+PG +T + ++ L R +IVG Sbjct: 95 GTTLSADAIVIATGSRARTMALPGSQLPGV---VTLRTYGDVQVLRDSWTSATRLLIVGG 151 Query: 240 GYIAVEMAGILSALGSKTSLMIRHDKVL-RSFDSMISTNCTEELENAGVEVLKFSQVKEV 298 G I E+A LG +++ D++L R I L GV+V E+ Sbjct: 152 GLIGCEVATTARKLGLSVTILEAGDELLVRVLGRRIGAWLRGLLTELGVQV-------EL 204 Query: 299 KKTLSGL----EVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDK 354 + G ++ V A GR V D L +G P D + G+ D + Sbjct: 205 GTGVVGFSGEGQLEQVMASDGRSFV------ADSALICVGAEP--ADQLARQAGLACD-R 255 Query: 355 GHIIVDEFQNTNVKGIYAVGDVC 377 G +IVD T KG++AVGDV Sbjct: 256 G-VIVDHCGATLAKGVFAVGDVA 277 >1NAA-A nrPDB Length = 541 Score = 35.0 bits (79), Expect = 0.077, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 27/44 (61%), Gaps = 5/44 (11%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVE-----SHKLGGTCV 103 YDY+++G G GG+ +A R +E G + ++E + + GGT V Sbjct: 3 YDYIIVGAGPGGIIAADRLSEAGKKVLLLERGGPSTKQTGGTYV 46 >3UKH-A nrPDB Length = 519 Score = 34.7 bits (78), Expect = 0.094, Method: Compositional matrix adjust. Identities = 19/62 (30%), Positives = 32/62 (51%), Gaps = 1/62 (1%) Query: 64 SYDYLVIGGGSGGLASARRAAEL-GARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEF 122 S D LVIG G GL +A+R ++ G +V+S++ G + P+ +++ H F Sbjct: 6 SVDVLVIGAGPTGLGAAKRLNQIDGPSWMIVDSNETPGGLASTDVTPEGFLYDVGGHVIF 65 Query: 123 MH 124 H Sbjct: 66 SH 67 >6C26-B nrPDB Length = 430 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 17/29 (58%), Positives = 19/29 (65%) Query: 334 GRVPNTKDLSLNKLGIQTDDKGHIIVDEF 362 G VPNT L LN+LGI KGH+I D F Sbjct: 116 GAVPNTIRLFLNELGIYPSPKGHVIRDYF 144 >4MO2-B nrPDB Length = 368 Score = 33.9 bits (76), Expect = 0.19, Method: Compositional matrix adjust. Identities = 17/39 (43%), Positives = 21/39 (53%), Gaps = 1/39 (2%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTC 102 YDYL++G G G A A E G VVE + +GG C Sbjct: 2 YDYLIVGSGLFGSIFAYEATEKGYTCLVVEQREHIGGNC 40 >2ZBW-A nrPDB Length = 335 Score = 33.1 bits (74), Expect = 0.33, Method: Compositional matrix adjust. Identities = 49/199 (24%), Positives = 80/199 (40%), Gaps = 21/199 (10%) Query: 187 SGKKYTAPHILIATGGMPSTPHESQIPGAS--------LGITSDGFFQLEELPGRSVIVG 238 G YTA ++IA G P PG + S FQ + R +IVG Sbjct: 104 QGNAYTAKAVIIAAGVGAFEPRRIGAPGEREFEGRGVYYAVKSKAEFQGK----RVLIVG 159 Query: 239 AGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEV 298 G AV+ A L + +L+ R + R+ ++ + + E +EVL +++ V Sbjct: 160 GGDSAVDWALNLLDTARRITLIHRRPQ-FRAHEASVK-ELMKAHEEGRLEVLTPYELRRV 217 Query: 299 KKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHII 358 + G E V + +VD +L G + L+ L ++ K I Sbjct: 218 E----GDERVRWAVVFHNQTQEELALEVDAVLILAGYITKLGPLANWGLALE---KNKIK 270 Query: 359 VDEFQNTNVKGIYAVGDVC 377 VD T++ G+YA GD+ Sbjct: 271 VDTTMATSIPGVYACGDIV 289 >6CR0-A nrPDB Length = 440 Score = 32.3 bits (72), Expect = 0.52, Method: Compositional matrix adjust. Identities = 15/37 (40%), Positives = 23/37 (62%), Gaps = 1/37 (2%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVES-HKLGG 100 YD +V+G G GL +AR + G ++E+ H+LGG Sbjct: 9 YDAIVVGAGFSGLVAARELSAQGRSVLIIEARHRLGG 45 >2YVG-A nrPDB Length = 408 Score = 32.3 bits (72), Expect = 0.53, Method: Compositional matrix adjust. Identities = 55/219 (25%), Positives = 91/219 (41%), Gaps = 25/219 (11%) Query: 166 HIEIIRGHAAFTSDPKPTIEVSGKKYTAPH--ILIATGGMPS---TPHESQIPGASLGIT 220 +E + G A + DP+ T P+ +++ATG P T + +P +L Sbjct: 73 EVEWLLGVTAQSFDPQAHTVALSDGRTLPYGTLVLATGAAPRALPTLQGATMPVHTLRTL 132 Query: 221 SDGF-FQLEELP-GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVL-RSFDSMISTN 277 D Q P R +IVG G I +E+A G SL+ +++ R+ + ++ Sbjct: 133 EDARRIQAGLRPQSRLLIVGGGVIGLELAATARTAGVHVSLVETQPRLMSRAAPATLADF 192 Query: 278 CTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVP 337 GV+ L+F + V ++ G+ + L T I D ++ IG + Sbjct: 193 VARYHAAQGVD-LRFE--RSVTGSVDGVVL---------LDDGTRIA-ADMVVVGIGVLA 239 Query: 338 NTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDV 376 N D G+ DD I VD + T +YA+GDV Sbjct: 240 N--DALARAAGLACDDG--IFVDAYGRTTCPDVYALGDV 274 >4YNU-A nrPDB Length = 571 Score = 31.6 bits (70), Expect = 0.94, Method: Compositional matrix adjust. Identities = 12/22 (54%), Positives = 17/22 (77%) Query: 64 SYDYLVIGGGSGGLASARRAAE 85 +YDY+V+GGG+ GL A R +E Sbjct: 5 TYDYIVVGGGTSGLVVANRLSE 26 >5KVH-A nrPDB Length = 543 Score = 31.6 bits (70), Expect = 0.97, Method: Compositional matrix adjust. Identities = 50/205 (24%), Positives = 82/205 (40%), Gaps = 25/205 (12%) Query: 187 SGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGF-----FQLEELPGRSV----IV 237 G + T LIATGG P + GA + + F F+ E R V I+ Sbjct: 171 DGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEKISREVKSITII 230 Query: 238 GAGYIAVEMAGILS----ALGSKT-SLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF 292 G G++ E+A L ALG++ L + + +S E++ GV+V+ Sbjct: 231 GGGFLGSELACALGRKARALGTEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPN 290 Query: 293 SQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD 352 + V+ V + L ++ GR + D ++ A+G PN + L I +D Sbjct: 291 AIVQSVGVSSGKL---LIKLKDGRK------VETDHIVAAVGLEPNVELAKTGGLEIDSD 341 Query: 353 DKGHIIVDEFQNTNVKGIYAVGDVC 377 G + E Q + I+ GD Sbjct: 342 FGGFRVNAELQARS--NIWVAGDAA 364 >3KLJ-A nrPDB Length = 385 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 68/318 (21%), Positives = 127/318 (39%), Gaps = 73/318 (22%) Query: 68 LVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHA 127 L++G G G ++A+ A G C ++ T ++SE Sbjct: 13 LILGAGPAGFSAAKAAL---------------GKCDDI----------TMINSEKY---- 43 Query: 128 DYGFPSCEGKFNWRVIKEKR-DAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEV 186 P + N + K K D + + N Y+ K++I++I A + DP + Sbjct: 44 ---LPYYRPRLNEIIAKNKSIDDILIKKNDWYE----KNNIKVITSEFATSIDPNNKLVT 96 Query: 187 --SGKKYTAPHILIATGGMPS---TPHESQIPGASLGITSDGFFQLEELP--GRSVIVGA 239 SG+K ++IA+G + + PH +I SL D +E G++ I+G Sbjct: 97 LKSGEKIKYEKLIIASGSIANKIKVPHADEI--FSLYSYDDALKIKDECKNKGKAFIIGG 154 Query: 240 GYIAVEMAGILSALGSKTSL-MIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEV 298 G + +E+A + G+ S+ +I + R D ++L+ G+++ S +E+ Sbjct: 155 GILGIELAQAIIDSGTPASIGIILEYPLERQLDRDGGLFLKDKLDRLGIKIYTNSNFEEM 214 Query: 299 KKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHII 358 + C++ A+G PN + ++ K I+ Sbjct: 215 GDLIRS----------------------SCVITAVGVKPNLDFIKDTEIA----SKRGIL 248 Query: 359 VDEFQNTNVKGIYAVGDV 376 V++ T++K IYA GDV Sbjct: 249 VNDHMETSIKDIYACGDV 266 >2BXR-A nrPDB Length = 527 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 15/42 (35%), Positives = 25/42 (59%), Gaps = 1/42 (2%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVNV 105 +D +VIGGG GL++A+ E G V+E+ ++GG + Sbjct: 14 FDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTI 55 >2VDC-G nrPDB Length = 456 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 21/75 (28%), Positives = 37/75 (49%), Gaps = 1/75 (1%) Query: 327 DCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD-EFQNTNVKGIYAVGDVCGKALLTPV 385 D ++ A+G P + ++ ++ G ++VD + TN+ G++A GD+ A L Sbjct: 368 DLVIKALGFEPEDLPNAFDEPELKVTRWGTLLVDHRTKMTNMDGVFAAGDIVRGASLVVW 427 Query: 386 AIAAGRKLAHRLFEY 400 AI GR A + Y Sbjct: 428 AIRDGRDAAEGIHAY 442 >2WHD-A nrPDB Length = 351 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 40/148 (27%), Positives = 69/148 (46%), Gaps = 16/148 (10%) Query: 236 IVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQV 295 ++G G A+E L+ GS+ ++ R + R+ M + L N ++V+ S+V Sbjct: 182 VIGGGDSAMEEGNFLTKYGSQVYIIHRRN-TFRASKIMQA----RALSNPKIQVVWDSEV 236 Query: 296 KEVKKTLSGLEVSMVTA---VPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD 352 E G ++ V V G + + V L +AIG P TK L+ +L + D Sbjct: 237 VEAYGGAGGGPLAGVKVKNLVTGEVSDL----QVSGLFFAIGHEPATKFLN-GQLELHAD 291 Query: 353 DKGHIIVDE-FQNTNVKGIYAVGDVCGK 379 G++ +T+V+G++A GDV K Sbjct: 292 --GYVATKPGSTHTSVEGVFAAGDVQDK 317 >5BR7-A nrPDB Length = 393 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 19/46 (41%), Positives = 28/46 (60%), Gaps = 4/46 (8%) Query: 62 VASYDYLVIGGGSGGLASARRAA-ELGARAAVVE--SHKLGGTCVN 104 ++ +D +V+G G GL A RAA +LG + +VE SH LGG + Sbjct: 1 MSDFDLIVVGSGLFGLTVAERAASQLGKKVLIVEKRSH-LGGNAYS 45 >3MJ4-A nrPDB Length = 397 Score = 30.0 bits (66), Expect = 2.3, Method: Compositional matrix adjust. Identities = 14/41 (34%), Positives = 21/41 (51%), Gaps = 1/41 (2%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVN 104 +DYL++G G G A R A G R +V+ +GG + Sbjct: 30 FDYLIVGAGFAGSVLAERLASSGQRVLIVDRRPHIGGNAYD 70 >1I8T-A nrPDB Length = 367 Score = 30.0 bits (66), Expect = 2.5, Method: Compositional matrix adjust. Identities = 13/44 (29%), Positives = 21/44 (47%), Gaps = 1/44 (2%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVES-HKLGGTCVNVGC 107 YDY+++G G G A +L + V+E + +GG C Sbjct: 2 YDYIIVGSGLFGAVCANELKKLNKKVLVIEKRNHIGGNAYTEDC 45 >5EQD-A nrPDB Length = 400 Score = 30.0 bits (66), Expect = 2.6, Method: Compositional matrix adjust. Identities = 17/46 (36%), Positives = 25/46 (54%), Gaps = 2/46 (4%) Query: 61 AVASYDYLVIGGGSGGLASARRAA-ELGARAAVVESH-KLGGTCVN 104 + ++D V+G G GL A RAA +LG R V+E +GG + Sbjct: 1 STGNFDLFVVGSGFFGLTIAERAATQLGKRVLVIERRPHIGGNAYS 46 >1O5W-A nrPDB Length = 534 Score = 30.0 bits (66), Expect = 2.7, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 25/42 (59%), Gaps = 1/42 (2%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVNV 105 +D +VIGGG GLA+A+ +E V+E+ ++GG V Sbjct: 22 FDVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTV 63 >3LP8-A nrPDB Length = 442 Score = 29.6 bits (65), Expect = 3.1, Method: Compositional matrix adjust. Identities = 34/150 (22%), Positives = 63/150 (42%), Gaps = 14/150 (9%) Query: 252 ALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVT 311 A G T + H++ + D+M+ + AG ++ +++ L G E+S T Sbjct: 169 AQGKGTVICHTHEEAYNAVDAML---VHHKFGEAGCAII-------IEEFLEGKEISFFT 218 Query: 312 AVPGRLPVMTMIPDVDCLLWAIGRVPNTKDL-SLNKLGIQTDDKGHIIVDEFQNTNVKGI 370 V G PV+ + + + PNT + S +K I T + HII+ + +K + Sbjct: 219 LVDGSNPVILGVAQDYKTIGDNNKGPNTGGMGSYSKPNIITQEMEHIIIQKIIYPTIKAM 278 Query: 371 YAVGDVCGKALLTPVAIAAGRKLAHRLFEY 400 + + L + I +K +L EY Sbjct: 279 FNMNIQFRGLLFAGIII---KKNEPKLLEY 305 >5KXJ-A nrPDB Length = 557 Score = 29.6 bits (65), Expect = 3.3, Method: Compositional matrix adjust. Identities = 11/27 (40%), Positives = 19/27 (70%) Query: 355 GHIIVDEFQNTNVKGIYAVGDVCGKAL 381 G ++VD++ T+V G+YA+G+V L Sbjct: 355 GGVVVDDYGRTDVDGLYAIGEVSYTGL 381 >5MIU-A nrPDB Length = 535 Score = 29.6 bits (65), Expect = 3.4, Method: Compositional matrix adjust. Identities = 50/208 (24%), Positives = 84/208 (40%), Gaps = 31/208 (14%) Query: 187 SGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGF-----FQLEELPGRSV----IV 237 G + T LIATGG P + GA + + F F+ E R V ++ Sbjct: 169 DGSQITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRALEKISREVKSITVI 228 Query: 238 GAGYIAVEMAGILSALGSKT--------SLMIRHDKVLRSFDSMISTNCTEELENAGVEV 289 G G++ E+A ALG K+ L + + +S E+++ GV+V Sbjct: 229 GEGFLGSELA---CALGRKSQASGIEVIQLFPEKGNMGKILPQYLSNWTMEKVKREGVKV 285 Query: 290 LKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGI 349 + + V+ V +SG + ++ GR + D ++ A+G PN + L I Sbjct: 286 MPNAIVQSV--GVSGGRL-LIKLKDGRK------VETDHIVTAVGLEPNVELAKTGGLEI 336 Query: 350 QTDDKGHIIVDEFQNTNVKGIYAVGDVC 377 +D G + E Q + I+ GD Sbjct: 337 DSDFGGFRVNAELQARS--NIWVAGDAA 362 >3NK2-X nrPDB Length = 431 Score = 29.3 bits (64), Expect = 3.9, Method: Compositional matrix adjust. Identities = 15/37 (40%), Positives = 22/37 (59%), Gaps = 1/37 (2%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVE-SHKLGG 100 YD +V+GGG GL +AR G + ++E +LGG Sbjct: 2 YDAIVVGGGFSGLKAARDLTNAGKKVLLLEGGERLGG 38 >4Y4N-A nrPDB Length = 286 Score = 29.3 bits (64), Expect = 4.8, Method: Compositional matrix adjust. Identities = 13/31 (41%), Positives = 19/31 (61%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVESH 96 D ++GGG GL +AR A+ G + V+E H Sbjct: 54 DVAIVGGGPSGLTAARYIAKEGYKVVVLERH 84 >3GG2-A nrPDB Length = 450 Score = 28.9 bits (63), Expect = 6.4, Method: Compositional matrix adjust. Identities = 17/46 (36%), Positives = 24/46 (52%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVP 109 S D V+G G GL SA AELGA +++ + +N G +P Sbjct: 2 SLDIAVVGIGYVGLVSATCFAELGANVRCIDTDRNKIEQLNSGTIP 47 >3G17-A nrPDB Length = 294 Score = 28.5 bits (62), Expect = 6.9, Method: Compositional matrix adjust. Identities = 24/108 (22%), Positives = 53/108 (49%), Gaps = 15/108 (13%) Query: 219 ITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRH--DKVLRSFDSMIST 276 + +G+ QLE +P ++V YI+ G K ++ H D LR D+ ++ Sbjct: 94 LAQNGYGQLEHIPFKNVCQAVVYIS----------GQKKGDVVTHFRDYQLRIQDNALTR 143 Query: 277 NCTEELENAGVEVLKFSQVKEV--KKTLSGLEVSMVTAVPGRLPVMTM 322 + ++++ ++++ + +++ K L L ++ +TA+ GR V M Sbjct: 144 QFRDLVQDSQIDIVLEANIQQAIWYKLLVNLGINSITAL-GRQTVAIM 190 >2GMH-A nrPDB Length = 584 Score = 28.5 bits (62), Expect = 7.3, Method: Compositional matrix adjust. Identities = 15/51 (29%), Positives = 26/51 (50%), Gaps = 12/51 (23%) Query: 66 DYLVIGGGSGGLASARRAAELGA------------RAAVVESHKLGGTCVN 104 D +++G G GL++A R +L A +AA + +H L G C++ Sbjct: 37 DVVIVGAGPAGLSAATRLKQLAAQHEKDLRVCLVEKAAHIGAHTLSGACLD 87 >5M7S-A nrPDB Length = 916 Score = 28.1 bits (61), Expect = 8.8, Method: Compositional matrix adjust. Identities = 29/140 (20%), Positives = 58/140 (41%), Gaps = 19/140 (13%) Query: 231 PGRSVIVGAGYIAVEMAGILSAL-------GSKTSLMIRHDKVLRSFDSMISTNC----T 279 P + A + +E +L+ L G K + M+R + LR+ S++S NC + Sbjct: 542 PNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDS 601 Query: 280 EELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNT 339 E++E KF + + GL + M T + T++ D+ +W I + + Sbjct: 602 EKIEEWRSRAAKFEE-------MCGLVMGMFTRL-SNCANRTILYDMYSYVWDIKSIMSM 653 Query: 340 KDLSLNKLGIQTDDKGHIIV 359 + LG ++ ++ Sbjct: 654 VKSFVQWLGCRSHSSAQFLI 673 >4H7U-A nrPDB Length = 602 Score = 28.1 bits (61), Expect = 9.3, Method: Compositional matrix adjust. Identities = 11/21 (52%), Positives = 15/21 (71%) Query: 65 YDYLVIGGGSGGLASARRAAE 85 YD++V GGG+ GL A R +E Sbjct: 41 YDFIVAGGGTAGLVVASRLSE 61 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2AAQ-A nrPDB 680 0.0 6N7F-A nrPDB 546 e-156 1GEU-A nrPDB 541 e-154 5VDN-A nrPDB 540 e-154 5U1O-A nrPDB 525 e-149 5V36-A nrPDB 521 e-148 6B4O-A nrPDB 520 e-148 6DU7-A nrPDB 517 e-147 2HQM-A nrPDB 514 e-146 2R9Z-A nrPDB 512 e-145 1ZDL-A nrPDB 499 e-141 2X8H-A nrPDB 495 e-140 3O0H-A nrPDB 490 e-139 4LA1-A nrPDB 487 e-138 4KPR-E nrPDB 484 e-137 2CFY-A nrPDB 480 e-136 5W1J-A nrPDB 479 e-135 2WOV-A nrPDB 470 e-133 5J5Z-A nrPDB 466 e-131 4B1B-A nrPDB 464 e-131 2NVK-X nrPDB 464 e-131 2YAU-A nrPDB 462 e-130 1FEC-A nrPDB 460 e-130 4NEW-A nrPDB 459 e-129 5U8W-A nrPDB 456 e-128 3URH-A nrPDB 456 e-128 5TR3-A nrPDB 453 e-128 1EBD-A nrPDB 451 e-127 3LAD-A nrPDB 448 e-126 1DXL-A nrPDB 448 e-126 2YQU-A nrPDB 447 e-126 1V59-A nrPDB 444 e-125 4DNA-A nrPDB 442 e-124 1ONF-A nrPDB 442 e-124 2EQ6-A nrPDB 437 e-123 6AON-A nrPDB 436 e-122 6BZ0-A nrPDB 435 e-122 5X1Y-B nrPDB 426 e-119 4JDR-A nrPDB 417 e-117 2QAE-A nrPDB 412 e-115 1LVL-A nrPDB 396 e-110 6CMZ-A nrPDB 395 e-110 3II4-A nrPDB 386 e-107 4YWO-A nrPDB 362 e-100 1OJT-A nrPDB 351 4e-97 5U25-A nrPDB 348 4e-96 1ZK7-A nrPDB 342 2e-94 3IC9-A nrPDB 311 5e-85 3Q6J-A nrPDB 294 4e-80 1XDI-A nrPDB 293 1e-79 3L8K-A nrPDB 290 8e-79 5UWY-A nrPDB 220 1e-57 4GCM-A nrPDB 216 2e-56 4ZN0-A nrPDB 206 2e-53 5MJK-A nrPDB 203 2e-52 2Q7V-A nrPDB 203 2e-52 3CGD-A nrPDB 199 2e-51 6BWT-A nrPDB 197 1e-50 5UTH-A nrPDB 192 3e-49 1F6M-A nrPDB 191 6e-49 3ISH-A nrPDB 187 1e-47 5YGQ-A nrPDB 180 2e-45 3F8P-A nrPDB 178 4e-45 4FX9-A nrPDB 172 4e-43 3LZX-A nrPDB 170 1e-42 4CBQ-A nrPDB 169 3e-42 3NTA-A nrPDB 165 5e-41 2BC1-A nrPDB 165 6e-41 5ER0-A nrPDB 161 7e-40 4YRY-B nrPDB 159 3e-39 5JFC-L nrPDB 152 5e-37 5W4C-A nrPDB 152 6e-37 3D8X-A nrPDB 146 2e-35 2CDU-A nrPDB 145 6e-35 3IWA-A nrPDB 144 8e-35 6BPY-A nrPDB 141 5e-34 5VJ7-A nrPDB 141 7e-34 1YQZ-A nrPDB 140 1e-33 1VDC-A nrPDB 135 5e-32 5M5J-A nrPDB 131 9e-31 1Q1R-A nrPDB 125 5e-29 5JCN-A nrPDB 124 1e-28 Sequences not found previously or not previously below threshold: 5U63-A nrPDB 176 2e-44 2A87-A nrPDB 176 3e-44 5USX-A nrPDB 174 9e-44 3R9U-A nrPDB 162 3e-40 3ICS-A nrPDB 155 4e-38 6GAS-A nrPDB 155 6e-38 1NHQ-A nrPDB 150 1e-36 4JNQ-A nrPDB 145 7e-35 3AB1-A nrPDB 138 5e-33 2ZBW-A nrPDB 137 9e-33 6GAR-A nrPDB 137 1e-32 3OC4-A nrPDB 128 6e-30 2WHD-A nrPDB 126 2e-29 5XHU-A nrPDB 126 2e-29 4YKF-A nrPDB 120 2e-27 1FL2-A nrPDB 115 4e-26 5TWC-A nrPDB 111 1e-24 3LXD-A nrPDB 110 2e-24 1XHC-A nrPDB 108 6e-24 3FG2-P nrPDB 102 4e-22 2V3B-A nrPDB 98 8e-21 2VDC-G nrPDB 95 6e-20 2YVG-A nrPDB 90 3e-18 4EMJ-A nrPDB 87 3e-17 3KLJ-A nrPDB 83 2e-16 5KVH-A nrPDB 78 7e-15 4FK1-A nrPDB 77 2e-14 5MIU-A nrPDB 71 9e-13 5NA1-A nrPDB 71 1e-12 4NTC-A nrPDB 64 1e-10 4C5O-A nrPDB 64 1e-10 4G74-A nrPDB 64 2e-10 4USR-A nrPDB 63 2e-10 5JWC-A nrPDB 63 3e-10 1PS9-A nrPDB 60 3e-09 5NMX-A nrPDB 60 4e-09 4OVI-A nrPDB 59 5e-09 6JDK-A nrPDB 58 7e-09 2TMD-A nrPDB 58 1e-08 3UP5-A nrPDB 57 2e-08 1NAA-A nrPDB 54 2e-07 2CVJ-A nrPDB 53 2e-07 3H8L-A nrPDB 51 1e-06 5J7X-A nrPDB 50 2e-06 6A37-A nrPDB 49 4e-06 2VOU-A nrPDB 49 5e-06 5CQF-A nrPDB 48 7e-06 5BR7-A nrPDB 48 1e-05 3K30-A nrPDB 48 1e-05 1Y56-A nrPDB 47 2e-05 3T14-A nrPDB 46 3e-05 4Y4N-A nrPDB 46 4e-05 3RHA-A nrPDB 46 4e-05 2ZXH-A nrPDB 46 5e-05 2BXR-A nrPDB 45 6e-05 6ER9-A nrPDB 45 7e-05 4RG3-A nrPDB 45 8e-05 4Y4M-A nrPDB 45 8e-05 3NIX-A nrPDB 44 2e-04 1ZOV-A nrPDB 44 2e-04 1O5W-A nrPDB 44 2e-04 1I8T-A nrPDB 44 2e-04 3KVE-A nrPDB 43 2e-04 6CR0-A nrPDB 43 2e-04 2BRY-A nrPDB 43 2e-04 2JB2-A nrPDB 43 2e-04 4TXK-A nrPDB 43 3e-04 2UZZ-A nrPDB 43 3e-04 3BHF-A nrPDB 43 3e-04 4MOP-A nrPDB 43 3e-04 4TLZ-A nrPDB 43 4e-04 2GMH-A nrPDB 43 4e-04 1REO-A nrPDB 43 4e-04 3ATQ-A nrPDB 43 4e-04 3ABT-A nrPDB 43 5e-04 2VVL-G nrPDB 42 5e-04 5EQD-A nrPDB 42 5e-04 3HYW-A nrPDB 42 5e-04 5L3D-A nrPDB 42 7e-04 4AP1-A nrPDB 41 0.001 2E5V-A nrPDB 41 0.001 3MJ4-A nrPDB 41 0.001 3NK2-X nrPDB 41 0.001 1F8S-A nrPDB 41 0.002 3WE0-A nrPDB 40 0.003 4B68-A nrPDB 40 0.003 6C6P-A nrPDB 40 0.003 5L46-A nrPDB 39 0.005 6BRD-A nrPDB 39 0.005 3IHG-A nrPDB 39 0.005 1C0L-A nrPDB 38 0.008 4A6N-B nrPDB 38 0.008 2DKH-A nrPDB 38 0.008 2GAG-A nrPDB 38 0.010 3UKH-A nrPDB 38 0.010 2VHY-A nrPDB 38 0.011 4C3X-A nrPDB 38 0.011 4H7U-A nrPDB 38 0.011 4DGK-A nrPDB 38 0.012 1QO8-A nrPDB 37 0.016 1SEZ-A nrPDB 37 0.018 4K2X-A nrPDB 37 0.020 1FOH-A nrPDB 37 0.020 5KXJ-A nrPDB 37 0.021 3CP8-A nrPDB 37 0.024 4Z2R-A nrPDB 36 0.027 6H3G-A nrPDB 36 0.028 5X6R-A nrPDB 36 0.030 3KYB-A nrPDB 36 0.031 3FPZ-A nrPDB 36 0.036 4MO2-B nrPDB 36 0.037 1RP0-A nrPDB 36 0.040 4YNU-A nrPDB 36 0.045 4P9S-A nrPDB 36 0.048 3HDH-A nrPDB 36 0.048 5EZ7-A nrPDB 36 0.050 3JSK-A nrPDB 36 0.050 2GAG-B nrPDB 36 0.054 3COX-A nrPDB 36 0.057 5MOG-A nrPDB 35 0.067 4EIQ-A nrPDB 35 0.084 1F14-A nrPDB 35 0.086 1GPE-A nrPDB 35 0.093 4RPJ-A nrPDB 35 0.099 5EB4-A nrPDB 35 0.10 5KOX-A nrPDB 35 0.11 6ACQ-A nrPDB 35 0.11 4N9X-A nrPDB 35 0.12 3OZ2-A nrPDB 35 0.12 5AYV-A nrPDB 35 0.13 1XDU-A nrPDB 34 0.13 3GDN-A nrPDB 34 0.13 1KNR-A nrPDB 34 0.14 5OWF-A nrPDB 34 0.14 6HRD-A nrPDB 34 0.15 2XVH-A nrPDB 34 0.15 5I68-A nrPDB 34 0.19 4UDQ-A nrPDB 34 0.21 5Y77-A nrPDB 34 0.21 3Q9T-A nrPDB 33 0.24 1E3J-A nrPDB 33 0.24 6MO6-A nrPDB 33 0.27 4K22-A nrPDB 33 0.28 3OJO-A nrPDB 33 0.31 3G5Q-A nrPDB 33 0.31 3HM2-A nrPDB 33 0.31 4NEG-A nrPDB 33 0.36 1X14-A nrPDB 33 0.37 3BI4-A nrPDB 33 0.38 3RED-A nrPDB 33 0.39 4MIF-A nrPDB 33 0.41 4HA6-A nrPDB 33 0.42 4U2L-A nrPDB 33 0.43 6J0Z-C nrPDB 33 0.45 3HN2-A nrPDB 33 0.45 4IV9-A nrPDB 33 0.45 4G65-A nrPDB 33 0.46 2BS2-A nrPDB 33 0.47 5OC1-A nrPDB 33 0.48 1DOD-A nrPDB 33 0.48 5TUM-A nrPDB 33 0.49 3LOV-A nrPDB 32 0.58 2Y0D-A nrPDB 32 0.60 4Z25-A nrPDB 32 0.61 3VRD-B nrPDB 32 0.65 3CP2-A nrPDB 32 0.65 3G05-A nrPDB 32 0.69 3RP7-A nrPDB 32 0.70 2CDC-A nrPDB 32 0.71 5XGV-A nrPDB 32 0.76 5UY8-A nrPDB 32 0.77 4Z44-A nrPDB 32 0.81 3IHM-A nrPDB 32 0.83 3GG2-A nrPDB 31 0.89 3T7C-A nrPDB 31 0.98 3SM8-A nrPDB 31 1.2 3LLV-A nrPDB 31 1.2 4B2T-D nrPDB 31 1.2 4FHN-X nrPDB 31 1.3 6DLL-A nrPDB 31 1.4 1LTX-R nrPDB 31 1.4 3KKJ-A nrPDB 31 1.5 5NCC-A nrPDB 31 1.5 4ZCC-A nrPDB 31 1.7 4R16-A nrPDB 31 1.7 4B4O-A nrPDB 31 1.8 2GV8-A nrPDB 31 1.9 2YFH-A nrPDB 31 1.9 3GMC-A nrPDB 30 1.9 2CUL-A nrPDB 30 1.9 2EEZ-A nrPDB 30 2.1 2B76-A nrPDB 30 2.2 5WIT-1k nrPDB 30 2.5 1XFD-A nrPDB 30 2.6 4XRR-A nrPDB 30 2.8 2BTW-A nrPDB 30 2.8 1VRQ-A nrPDB 30 2.9 3R3S-A nrPDB 30 3.1 5X68-A nrPDB 30 3.2 2QA2-A nrPDB 30 3.3 5KYM-A nrPDB 30 3.4 5ZYN-B nrPDB 30 3.5 4X4J-A nrPDB 30 3.6 1LQU-A nrPDB 30 3.6 3CUK-A nrPDB 30 3.9 5XMJ-A nrPDB 29 4.4 5TUF-A nrPDB 29 4.6 3ADO-A nrPDB 29 4.8 4IIN-A nrPDB 29 5.0 2DI4-A nrPDB 29 5.0 5VT6-A nrPDB 29 5.1 3X2F-A nrPDB 29 5.3 2RGJ-A nrPDB 29 5.3 4Z8X-A nrPDB 29 5.4 1VE9-A nrPDB 29 6.3 3U0O-A nrPDB 29 7.1 1V8B-A nrPDB 28 7.9 4WES-A nrPDB 28 8.9 3F52-A nrPDB 28 9.2 3K6J-A nrPDB 28 9.8 >2AAQ-A nrPDB Length = 479 Score = 680 bits (1755), Expect = 0.0, Method: Composition-based stats. Identities = 479/479 (100%), Positives = 479/479 (100%) Query: 44 MACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCV 103 MACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCV Sbjct: 1 MACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCV 60 Query: 104 NVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLT 163 NVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLT Sbjct: 61 NVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLT 120 Query: 164 KSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDG 223 KSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDG Sbjct: 121 KSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDG 180 Query: 224 FFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELE 283 FFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELE Sbjct: 181 FFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELE 240 Query: 284 NAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLS 343 NAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLS Sbjct: 241 NAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLS 300 Query: 344 LNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKED 403 LNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKED Sbjct: 301 LNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKED 360 Query: 404 SKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVM 463 SKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVM Sbjct: 361 SKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVM 420 Query: 464 KMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 522 KMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR Sbjct: 421 KMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 479 >6N7F-A nrPDB Length = 453 Score = 546 bits (1407), Expect = e-156, Method: Composition-based stats. Identities = 242/462 (52%), Positives = 317/462 (68%), Gaps = 14/462 (3%) Query: 62 VASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSE 121 V YDY+VIGGGS G+ASA RAA GA+ + E ++GGTCVN+GCVPKKVMW A ++ Sbjct: 5 VIPYDYIVIGGGSAGIASANRAAMHGAKVLLAEGKEIGGTCVNLGCVPKKVMWYGAQVAD 64 Query: 122 FMHDHA-DYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP 180 + +A DYGF E F+++ +K R AY+ R++A Y+ ++ ++ I +A F Sbjct: 65 ILGTYAKDYGFDFKEKAFDFKQLKANRQAYIDRIHASYERGFEQNGVDRIYDYAVFKD-- 122 Query: 181 KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG 240 T+E++G+ YTAPHILIATGG P P I GA GI+SDGFF L+E+P R+ +VGAG Sbjct: 123 AHTVEIAGQLYTAPHILIATGGHPVFP---DIEGAQYGISSDGFFALDEVPKRTAVVGAG 179 Query: 241 YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK 300 YIAVE+AG+L ALGSKT L IRHD+ LRSFD I +E+ G + ++V +V K Sbjct: 180 YIAVELAGVLHALGSKTDLFIRHDRPLRSFDKTIVDVLVDEMAVNGPRLHTHAEVAKVVK 239 Query: 301 TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD 360 E + G+ +VD L+WAIGR PN + SL+K G+ +DKG+I D Sbjct: 240 NTD--ESLTLYLKDGQE------VEVDQLIWAIGRKPNLEGFSLDKTGVTLNDKGYIETD 291 Query: 361 EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP 420 ++NT+VKGIYAVGDV GK LTPVA+AAGR+L+ RLF K D KLDY N+ TV+FSHP Sbjct: 292 AYENTSVKGIYAVGDVNGKLALTPVAVAAGRRLSERLFNGKTDEKLDYQNVATVIFSHPV 351 Query: 421 IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ 480 IG+VGL+E+ A+ +YG E VKTY + FT M+ A+T + C+MK+V EK+VG+H Sbjct: 352 IGSVGLSEEAAVKQYGQEAVKTYQSRFTSMFTAITNHRQPCLMKLVTVGDTEKIVGLHGI 411 Query: 481 GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 522 G G DEM+QGFAVA+KMGATKADFDNTVAIHPT SEE VT+R Sbjct: 412 GYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR 453 >1GEU-A nrPDB Length = 450 Score = 541 bits (1393), Expect = e-154, Method: Composition-based stats. Identities = 234/443 (52%), Positives = 297/443 (67%), Gaps = 14/443 (3%) Query: 81 RRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDH-ADYGFPSCEGKFN 139 RAA G + A++E+ +LGGTCVNVGCVPKKVMW+ A E +H + DYGF + KFN Sbjct: 21 NRAAMYGQKCALIEAKELGGTCVNVGCVPKKVMWHAAQIREAIHMYGPDYGFDTTINKFN 80 Query: 140 WRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIA 199 W + R AY+ R++ Y+N L K+++++I+G A F T+EV+G+ TA HILIA Sbjct: 81 WETLIASRTAYIDRIHTSYENVLGKNNVDVIKGFARFVD--AKTLEVNGETITADHILIA 138 Query: 200 TGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSL 259 TGG PS P IPG GI SDGFF L LP R +VGAGYI VE+ G+++ LG+KT L Sbjct: 139 TGGRPSHP---DIPGVEYGIDSDGFFALPALPERVAVVGAGYIGVELGGVINGLGAKTHL 195 Query: 260 MIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPV 319 D L SFD MIS E + G ++ + K V K G + GR Sbjct: 196 FEMFDAPLPSFDPMISETLVEVMNAEGPQLHTNAIPKAVVKNTDGS--LTLELEDGRSET 253 Query: 320 MTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGK 379 VDCL+WAIGR P +++L G++T++KG+I+VD++QNTN++GIYAVGD G Sbjct: 254 ------VDCLIWAIGREPANDNINLEAAGVKTNEKGYIVVDKYQNTNIEGIYAVGDNTGA 307 Query: 380 ALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIEN 439 LTPVA+AAGR+L+ RLF K D LDY+NIPTVVFSHPPIGTVGLTE +A +YG + Sbjct: 308 VELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTVGLTEPQAREQYGDDQ 367 Query: 440 VKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGA 499 VK Y +SFT MY AVT + C MK+VC EEK+VGIH G G DEMLQGFAVA+KMGA Sbjct: 368 VKVYKSSFTAMYTAVTTHRQPCRMKLVCVGSEEKIVGIHGIGFGMDEMLQGFAVALKMGA 427 Query: 500 TKADFDNTVAIHPTSSEELVTLR 522 TK DFDNTVAIHPT++EE VT+R Sbjct: 428 TKKDFDNTVAIHPTAAEEFVTMR 450 >5VDN-A nrPDB Length = 463 Score = 540 bits (1392), Expect = e-154, Method: Composition-based stats. Identities = 233/443 (52%), Positives = 302/443 (68%), Gaps = 14/443 (3%) Query: 81 RRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDH-ADYGFPSCEGKFN 139 RAA G + A++E+ +LGGTCVNVGCVPKKVMW+ A +E +H + DYGF + F+ Sbjct: 34 NRAAMYGKKCALIEAKQLGGTCVNVGCVPKKVMWHAAQIAEAIHLYGPDYGFDTTVNHFD 93 Query: 140 WRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIA 199 W+ + R AY+ R++ Y+ L + +++I+G A F T+EV+G+ TA HILIA Sbjct: 94 WKKLIANRTAYIDRIHQSYERGLGNNKVDVIQGFARFVD--AHTVEVNGETITADHILIA 151 Query: 200 TGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSL 259 TGG PS P IPGA GI SDGFF+L+E+P R +VGAGYIAVE+AG+L+ LG++T L Sbjct: 152 TGGRPSHP---DIPGAEYGIDSDGFFELDEMPKRVAVVGAGYIAVEIAGVLNGLGTETHL 208 Query: 260 MIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPV 319 +R LR+FD +I E + G ++ S K V K G + Sbjct: 209 FVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESVPKAVIKNADGSLTLQLEN------- 261 Query: 320 MTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGK 379 VD L+WAIGR P T +L+L+ G++T+DKG+I VD+FQNTNVKGIYAVGD G Sbjct: 262 -GTEVTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKFQNTNVKGIYAVGDNTGV 320 Query: 380 ALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIEN 439 LTPVA+AAGR+L+ RLF K D LDY+NIPTVVFSHPPIGT+GLTE +A K+G + Sbjct: 321 VELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTIGLTEPQAREKFGDDQ 380 Query: 440 VKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGA 499 VK Y++SFT MY AVT+ + C MK+VC EEK+VGIH G G DE+LQGFAVA+KMGA Sbjct: 381 VKVYTSSFTAMYSAVTQHRQPCRMKLVCVGAEEKIVGIHGIGFGMDEILQGFAVAMKMGA 440 Query: 500 TKADFDNTVAIHPTSSEELVTLR 522 TK DFDNTVAIHPT++EE VT+R Sbjct: 441 TKKDFDNTVAIHPTAAEEFVTMR 463 >5U1O-A nrPDB Length = 458 Score = 525 bits (1353), Expect = e-149, Method: Composition-based stats. Identities = 230/444 (51%), Positives = 294/444 (66%), Gaps = 15/444 (3%) Query: 81 RRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHA-DYGFPSCEGKFN 139 RAA GA+ A++E+ LGGTCVNVGCVPKKVMW+ A +E M+ +A DYGF F+ Sbjct: 28 NRAAMYGAKVALIEAQDLGGTCVNVGCVPKKVMWHGAQIAEAMNLYAEDYGFDVDVKGFD 87 Query: 140 WRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIA 199 W + E R AY+ R++ Y L + + +I+G A F + T+EV+G+ YTA HILIA Sbjct: 88 WSKLVESRQAYIGRIHQSYDRVLGNNKVNVIKGFAKFVDEK--TVEVNGEHYTADHILIA 145 Query: 200 TGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSL 259 GG P+ P IPGA GI S+GFF L E P R +VGAGYIAVE+AG+L ALG++T L Sbjct: 146 VGGRPTIP---NIPGAEYGIDSNGFFDLAEQPKRVAVVGAGYIAVEIAGVLHALGTETHL 202 Query: 260 MIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPV 319 +R + LRSFD MI E +E G + S KEV K G + Sbjct: 203 FVRKESPLRSFDPMIIDTLVEVMEAEGPTLHTHSVPKEVVKEADGSLTLHLEN------- 255 Query: 320 MTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVC-G 378 +VD L+WAIGR P T ++L G+ T++KG+I VDE+Q TNVKGIY VGD+ G Sbjct: 256 -GESQNVDQLIWAIGRHPATDAINLASTGVATNEKGYIKVDEYQETNVKGIYCVGDIMEG 314 Query: 379 KALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIE 438 LTPVA+ AGR+L+ RLF K ++K+DY+ +PTVVFSHPPIGT+GLT EA KYG + Sbjct: 315 GIELTPVAVKAGRQLSERLFNNKPNAKMDYDLVPTVVFSHPPIGTIGLTTQEAEEKYGKD 374 Query: 439 NVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMG 498 N+K Y++ FT MY AVTK + C MK+VCA +EE VVG+H G DEM+QGF VA+KMG Sbjct: 375 NIKVYTSGFTAMYTAVTKHRQPCKMKLVCAGEEETVVGLHGIGFTVDEMIQGFGVAMKMG 434 Query: 499 ATKADFDNTVAIHPTSSEELVTLR 522 ATKADFD+ VAIHPT SEE VT+R Sbjct: 435 ATKADFDSVVAIHPTGSEEFVTMR 458 >5V36-A nrPDB Length = 453 Score = 521 bits (1343), Expect = e-148, Method: Composition-based stats. Identities = 234/461 (50%), Positives = 310/461 (67%), Gaps = 14/461 (3%) Query: 63 ASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEF 122 YDY+VIGGGSGG+ASA RAA GA+ + E ++GGTCVNVGCVPKKVMW A +E Sbjct: 6 KQYDYIVIGGGSGGIASANRAAMHGAKVILFEGKQVGGTCVNVGCVPKKVMWYGAQVAET 65 Query: 123 MHD-HADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPK 181 +++ ADYGF F++ V+K+ R AY+ R++ Y+ + +E + G+A F Sbjct: 66 INNYAADYGFDVTTQAFHFDVLKQNRQAYIDRIHDSYERGFDSNGVERVYGYATFVD--A 123 Query: 182 PTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGY 241 T+EV+G+ YTAPHILIATGG P IPG+ GITSDGFF+L+ +P R+ +VGAGY Sbjct: 124 HTVEVAGEHYTAPHILIATGGHALLP---DIPGSEYGITSDGFFELDAIPKRTAVVGAGY 180 Query: 242 IAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKT 301 IAVE++GIL ALGS+T L +R D+ LR FD I +E++ G + FS KEV K Sbjct: 181 IAVEISGILHALGSETHLFVRRDRPLRKFDKEIVGTLVDEMKKDGPHLHTFSVPKEVIKN 240 Query: 302 LSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDE 361 ++ VD L+WAIGR NTK +L G+ D +G I D Sbjct: 241 TDNSLTLILEN--------GEEYTVDTLIWAIGRAANTKGFNLEVTGVTLDSRGFIATDA 292 Query: 362 FQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPI 421 F+NTNV+G+YA+GDV GK LTPVA+ AGR+L+ RLF +K +K+DY ++ TV+FSHP I Sbjct: 293 FENTNVEGLYALGDVNGKLELTPVAVKAGRQLSERLFNHKPQAKMDYKDVATVIFSHPVI 352 Query: 422 GTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQG 481 G++GL+E+ A+ +YG ENV Y ++FT MY AVT + C MK+V ++EK+VG+H G Sbjct: 353 GSIGLSEEAALDQYGEENVTVYRSTFTSMYTAVTSHRQACKMKLVTVGEDEKIVGLHGIG 412 Query: 482 LGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 522 G DEM+QGFAVA+KMGATKADFDNTVAIHPT SEE VT+R Sbjct: 413 YGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR 453 >6B4O-A nrPDB Length = 452 Score = 520 bits (1340), Expect = e-148, Method: Composition-based stats. Identities = 236/465 (50%), Positives = 307/465 (66%), Gaps = 14/465 (3%) Query: 59 AGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAV 118 + A+ +YDY+VIGGGSGG+ASA RA GA ++E +++GGTCVNVGCVPKKVMW + Sbjct: 1 SNAMKTYDYIVIGGGSGGIASANRAGMHGANVLLIEGNEIGGTCVNVGCVPKKVMWQASS 60 Query: 119 HSEFM-HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFT 177 E M D A YGF F+++ + E R+ Y+ L+ Y L ++IE I G+A FT Sbjct: 61 MMEMMERDTAGYGFDVEIKNFSFKQLVENREKYIDFLHGAYNRGLDSNNIERIHGYATFT 120 Query: 178 SDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIV 237 + TIEV+G +YTAPHILIATGG P + IPG + S+GFF LEE+P R V V Sbjct: 121 GEQ--TIEVNGTEYTAPHILIATGGR---PKKLGIPGEEYALDSNGFFALEEMPKRVVFV 175 Query: 238 GAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKE 297 GAGYIA E+AG L LG++T RH++ LRSFD M+S E + G+++ + + Sbjct: 176 GAGYIAAELAGTLHGLGAETHWAFRHERPLRSFDDMLSEKVVERYQEMGMQIHPNATPAK 235 Query: 298 VKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHI 357 ++KT V D +++ GR PNT L L + D+KG++ Sbjct: 236 IEKTAQNEYVITFEN--------GESITTDAVIFGTGRQPNTDQLGLENTKVALDEKGYV 287 Query: 358 IVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFS 417 VD+FQNT GIYAVGDV GK LTPVAIAAGR+L+ RLF + D LDYN +PTVVF+ Sbjct: 288 KVDKFQNTTQNGIYAVGDVIGKIDLTPVAIAAGRRLSERLFNGQTDLYLDYNLVPTVVFT 347 Query: 418 HPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGI 477 HPP+ T+GLTE A+ +YG + VK Y +SFTPMY A+ + + KC MK++C KEEK+VG+ Sbjct: 348 HPPVATIGLTEKAALEEYGEDQVKIYRSSFTPMYFALGEYRQKCDMKLICVGKEEKIVGL 407 Query: 478 HMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 522 H G+G DEMLQGFAVA+KMGATKADFDNTVAIHPT SEE VT+R Sbjct: 408 HGIGIGVDEMLQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR 452 >6DU7-A nrPDB Length = 448 Score = 517 bits (1331), Expect = e-147, Method: Composition-based stats. Identities = 216/443 (48%), Positives = 284/443 (64%), Gaps = 15/443 (3%) Query: 81 RRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHA-DYGFPSCEGKFN 139 RA E GA+AAV+E KLGGTCVNVGCVPKK+MW A +E H DYGF + + F+ Sbjct: 20 NRAGEHGAQAAVIEEKKLGGTCVNVGCVPKKIMWYGAQIAETFHQFGEDYGFKTTDLNFD 79 Query: 140 WRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIA 199 + ++ R++Y+ R + Y + ++ +++I GHA F T+ V+G+ A HI+IA Sbjct: 80 FATLRRNRESYIDRARSSYDGSFKRNGVDLIEGHAEFVD--SHTVSVNGELIRAKHIVIA 137 Query: 200 TGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSL 259 TG PS P IPGA LG +SD F EELP I+GAGYIAVE+AG+L G KT L Sbjct: 138 TGAHPSIP---NIPGAELGGSSDDVFAWEELPESVAILGAGYIAVELAGVLHTFGVKTDL 194 Query: 260 MIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPV 319 +R D+ LR FDS I +E+E + + +++KT G+ + Sbjct: 195 FVRRDRPLRGFDSYIVEGLVKEMERTNLPLHTHKVPVKLEKTTDGITIHFEDGTS----- 249 Query: 320 MTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGK 379 ++WA GR PN K L L K G+ +++G I VDE+QNT V+GIYA+GDV G+ Sbjct: 250 ----HTASQVIWATGRRPNVKGLQLEKAGVTLNERGFIQVDEYQNTVVEGIYALGDVTGE 305 Query: 380 ALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIEN 439 LTPVAI AGR L+ RLF K +K+DY+ IPTVVFSHP IGTVGLTE++AI +YG + Sbjct: 306 KELTPVAIKAGRTLSERLFNGKTTAKMDYSTIPTVVFSHPAIGTVGLTEEQAIKEYGQDQ 365 Query: 440 VKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGA 499 +K Y +SF MY A T+ + + K++ A EEKVVG+H G G DEM+QGFAVA+KMGA Sbjct: 366 IKVYKSSFASMYSACTRNRQESRFKLITAGSEEKVVGLHGIGYGVDEMIQGFAVAIKMGA 425 Query: 500 TKADFDNTVAIHPTSSEELVTLR 522 TKADFD TVAIHPTSSEE VT+R Sbjct: 426 TKADFDATVAIHPTSSEEFVTMR 448 >2HQM-A nrPDB Length = 479 Score = 514 bits (1324), Expect = e-146, Method: Composition-based stats. Identities = 233/471 (49%), Positives = 304/471 (64%), Gaps = 20/471 (4%) Query: 63 ASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEF 122 YDYLVIGGGSGG+ASARRAA GA+ +VE+ LGGTCVNVGCVPKKVMW + + Sbjct: 10 KHYDYLVIGGGSGGVASARRAASYGAKTLLVEAKALGGTCVNVGCVPKKVMWYASDLATR 69 Query: 123 MHDHADYGF------PSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAF 176 + +YG FNW K+KRDAYV RLN IYQ NL K ++++ G A F Sbjct: 70 VSHANEYGLYQNLPLDKEHLTFNWPEFKQKRDAYVHRLNGIYQKNLEKEKVDVVFGWARF 129 Query: 177 TSDPKPTI---EVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGR 233 D + + + + Y+A HIL+ATGG P IPG LG SDGFF+LEE P + Sbjct: 130 NKDGNVEVQKRDNTTEVYSANHILVATGGKAIFPE--NIPGFELGTDSDGFFRLEEQPKK 187 Query: 234 SVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFS 293 V+VGAGYI +E+AG+ LGS+T L+IR + VLR FD I T+ G+ V K S Sbjct: 188 VVVVGAGYIGIELAGVFHGLGSETHLVIRGETVLRKFDECIQNTITDHYVKEGINVHKLS 247 Query: 294 QVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDD 353 ++ +V+K + ++ + + I DVD L+W IGR + + +GI+ + Sbjct: 248 KIVKVEKNVETDKLKI------HMNDSKSIDDVDELIWTIGRKSHL-GMGSENVGIKLNS 300 Query: 354 KGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFE--YKEDSKLDYNNI 411 II DE+QNTNV IY++GDV GK LTPVAIAAGRKL++RLF + KLDY N+ Sbjct: 301 HDQIIADEYQNTNVPNIYSLGDVVGKVELTPVAIAAGRKLSNRLFGPEKFRNDKLDYENV 360 Query: 412 PTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKE 471 P+V+FSHP G++G++E EAI KYG EN+K Y++ FT MY+A+ K+ K+VCA Sbjct: 361 PSVIFSHPEAGSIGISEKEAIEKYGKENIKVYNSKFTAMYYAMLSEKSPTRYKIVCAGPN 420 Query: 472 EKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 522 EKVVG+H+ G E+LQGF VA+KMGATKADFDN VAIHPTS+EELVT+R Sbjct: 421 EKVVGLHIVGDSSAEILQGFGVAIKMGATKADFDNCVAIHPTSAEELVTMR 471 >2R9Z-A nrPDB Length = 463 Score = 512 bits (1319), Expect = e-145, Method: Composition-based stats. Identities = 220/460 (47%), Positives = 298/460 (64%), Gaps = 14/460 (3%) Query: 63 ASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEF 122 +D + IGGGSGGLA A +AA G R A++ES LGGTCVNVGCVPKKVMW + +E Sbjct: 3 QHFDLIAIGGGSGGLAVAEKAAAFGKRVALIESKALGGTCVNVGCVPKKVMWYASHLAEA 62 Query: 123 MHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKP 182 + D +G + G +W + RD Y+ +N+ + + + I + GHA F Sbjct: 63 VRDAPGFGVQASGGTLDWPRLVAGRDRYIGAINSFWDGYVERLGITRVDGHARFVD--AH 120 Query: 183 TIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYI 242 TIEV G++ +A HI+IATGG P P ++PGA LGITSDGFF L++ P R I+GAGYI Sbjct: 121 TIEVEGQRLSADHIVIATGGRPIVP---RLPGAELGITSDGFFALQQQPKRVAIIGAGYI 177 Query: 243 AVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTL 302 +E+AG+L + GS+ +++ D++L FD ++S E + G+E V +++ Sbjct: 178 GIELAGLLRSFGSEVTVVALEDRLLFQFDPLLSATLAENMHAQGIETHLEFAVAALERDA 237 Query: 303 SGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEF 362 G + T + D ++WA+GR PNT+DL L GI+ G + D + Sbjct: 238 QGTTLVAQDG--------TRLEGFDSVIWAVGRAPNTRDLGLEAAGIEVQSNGMVPTDAY 289 Query: 363 QNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIG 422 QNTNV G+YA+GD+ G+ LTPVAIAAGR+LA RLF+ + + KLDY+NIPTVVF+HPP+ Sbjct: 290 QNTNVPGVYALGDITGRDQLTPVAIAAGRRLAERLFDGQSERKLDYDNIPTVVFAHPPLS 349 Query: 423 TVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGL 482 VGL+E EA + G + Y TSFTPM +A+ + K MK+VCA E++VVG+H+ G Sbjct: 350 KVGLSEPEARERLGDV-LTVYETSFTPMRYALNEHGPKTAMKLVCAGPEQRVVGVHVIGD 408 Query: 483 GCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 522 G DEMLQGFAVAVKMGATKADFDNTVAIHP S+EELVTL+ Sbjct: 409 GADEMLQGFAVAVKMGATKADFDNTVAIHPGSAEELVTLK 448 >1ZDL-A nrPDB Length = 517 Score = 499 bits (1285), Expect = e-141, Method: Composition-based stats. Identities = 198/484 (40%), Positives = 279/484 (57%), Gaps = 27/484 (5%) Query: 58 AAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVE---------SHKLGGTCVNVGCV 108 AAG S+D LVIGGGSGGLA A+ AA+LG + AV + LGGTCVNVGC+ Sbjct: 26 AAGGQQSFDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCI 85 Query: 109 PKKVMWNTAVHSEFMHDHADYGFPSCEG-KFNWRVIKEKRDAYVSRLNAIYQNNLTKSHI 167 PKK+M A+ + D YG+ + + NW+ + E +V LN ++ L + Sbjct: 86 PKKLMHQAALLGGMIRDAHHYGWEVAQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKV 145 Query: 168 EIIRGHAAFTSDPKPTIEVSGKK---YTAPHILIATGGMPSTPHESQIPGA-SLGITSDG 223 + A+F + G K +A HI+IATGG P P +Q+ GA GITSD Sbjct: 146 KYFNIKASFVDEHTVRGVDKGGKATLLSAEHIVIATGGRPRYP--TQVKGALEYGITSDD 203 Query: 224 FFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELE 283 F L+E PG++++VGA Y+A+E AG L+ +G T++M+R LR FD +S+ TE +E Sbjct: 204 IFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTVMMR-SIPLRGFDQQMSSLVTEHME 262 Query: 284 NAGVEVLKFSQVKEVKKT-LSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDL 342 + G + LK +KK + L+V+ G+ T D +LWAIGRVP T+ L Sbjct: 263 SHGTQFLKGCVPSHIKKLPTNQLQVTWEDHASGKEDTGT----FDTVLWAIGRVPETRTL 318 Query: 343 SLNKLGIQTDDKGH-IIVDEFQNTNVKGIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEY 400 +L K GI T+ K IIVD + T+V IYA+GDV G+ LTP AI AG+ LA RLF Sbjct: 319 NLEKAGISTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFG- 377 Query: 401 KEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRK-T 459 K + +DY+N+PT VF+ G VGL+E+EA+ +G E+V+ Y + P+ V R + Sbjct: 378 KSSTLMDYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRDAS 437 Query: 460 KCVMKMVCANKE-EKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 +C +KMVC + + V+G+H G E+ QGFA+ +K GA+ A TV IHPT SEE+ Sbjct: 438 QCYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEV 497 Query: 519 VTLR 522 V L Sbjct: 498 VKLH 501 >2X8H-A nrPDB Length = 598 Score = 495 bits (1276), Expect = e-140, Method: Composition-based stats. Identities = 170/481 (35%), Positives = 261/481 (54%), Gaps = 27/481 (5%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVE---------SHKLGGTCVNVGCVPKKVMW 114 YD +VIGGGSGGLA+ + AA+ GA+ AV++ + LGGTCVNVGC+PKK+M Sbjct: 107 DYDLIVIGGGSGGLAAGKEAAKYGAKTAVLDYVEPTPIGTTWGLGGTCVNVGCIPKKLMH 166 Query: 115 NTAVHSEFMHDHADYGFPSCEGK--FNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRG 172 + S + D +G+ K NW + E +++ LN Y+ L + + + Sbjct: 167 QAGLLSHALEDAEHFGWSLDRSKISHNWSTMVEGVQSHIGSLNWGYKVALRDNQVTYLNA 226 Query: 173 HAAFTSDPKPTIEVSGK---KYTAPHILIATGGMPSTPHESQIPG-ASLGITSDGFFQLE 228 S + I + T I++ATG P P +IPG GITSD F L Sbjct: 227 KGRLISPHEVQITDKNQKVSTITGNKIILATGERPKYP---EIPGAVEYGITSDDLFSLP 283 Query: 229 ELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVE 288 PG+++++GA Y+A+E AG L++LG ++M+R +LR FD ++ + +EN GV+ Sbjct: 284 YFPGKTLVIGASYVALECAGFLASLGGDVTVMVR-SILLRGFDQQMAEKVGDYMENHGVK 342 Query: 289 VLKFSQVKEVKK----TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSL 344 K E+K+ + ++ + + +++A+GR P + Sbjct: 343 FAKLCVPDEIKQLKVVDTENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSKVLC 402 Query: 345 NKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKED 403 +G++ D G ++ + + T V +YA+GD+ GK LTPVAI AGR LA RLF Sbjct: 403 ETVGVKLDKNGRVVCTDDEQTTVSNVYAIGDINAGKPQLTPVAIQAGRYLARRLFAGAT- 461 Query: 404 SKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTK-CV 462 DY+N+ T VF+ G GL+E++AI KYG ++++ Y ++F P+ V R+ C Sbjct: 462 ELTDYSNVATTVFTPLEYGACGLSEEDAIEKYGDKDIEVYHSNFKPLEWTVAHREDNVCY 521 Query: 463 MKMVCANKEE-KVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTL 521 MK+VC + +V+G+H+ G E+ QG+AVA+KMGATKADFD T+ IHPT SE TL Sbjct: 522 MKLVCRKSDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKADFDRTIGIHPTCSETFTTL 581 Query: 522 R 522 Sbjct: 582 H 582 >3O0H-A nrPDB Length = 484 Score = 490 bits (1263), Expect = e-139, Method: Composition-based stats. Identities = 176/473 (37%), Positives = 258/473 (54%), Gaps = 16/473 (3%) Query: 49 EPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCV 108 E Q QGP + +D VIG GSGG+ +AR A LG R A+ E +++GGTCV GCV Sbjct: 13 EAQTQGP--GSMGSFDFDLFVIGSGSGGVRAARLAGALGKRVAIAEEYRIGGTCVIRGCV 70 Query: 109 PKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIE 168 PKK+ + + +++ +G+ + FNW + ++ +SRL +Y+ L S++ Sbjct: 71 PKKLYFYASQYAQEFSKSIGFGWKYADPIFNWEKLVAAKNKEISRLEGLYREGLQNSNVH 130 Query: 169 IIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLE 228 I A F + + V+G++ +A ILIATG S I G+ L +TS+ F LE Sbjct: 131 IYESRAVFVDEHTLELSVTGERISAEKILIATGAK--IVSNSAIKGSDLCLTSNEIFDLE 188 Query: 229 ELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVE 288 +LP VIVG GYI VE A I LG KT+L+ R D +LR+FD + + + G+ Sbjct: 189 KLPKSIVIVGGGYIGVEFANIFHGLGVKTTLLHRGDLILRNFDYDLRQLLNDAMVAKGIS 248 Query: 289 VLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLG 348 ++ + V +V+ T + V + D ++ A GRVPNT L L + G Sbjct: 249 IIYEATVSQVQSTENCYNVVLTNGQT---------ICADRVMLATGRVPNTTGLGLERAG 299 Query: 349 IQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDY 408 ++ ++ G ++VDE TNV I+AVGDV G LTPVAI FE + DY Sbjct: 300 VKVNEFGAVVVDEKMTTNVSHIWAVGDVTGHIQLTPVAIHDAMCFVKNAFEN-TSTTPDY 358 Query: 409 NNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCA 468 + I T VFS P IGTVGL+E++A+H+Y + V+ Y T F PM + ++ K MK+V Sbjct: 359 DLITTAVFSQPEIGTVGLSEEDALHRY--KRVEIYRTVFRPMRNVLSGSPEKMFMKLVVD 416 Query: 469 NKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTL 521 + VVG H+ G E+ Q +++K TK FD T+A+HPT SEELVT+ Sbjct: 417 GESRIVVGAHVLGENAGEIAQLIGISLKGKLTKDIFDKTMAVHPTMSEELVTM 469 >4LA1-A nrPDB Length = 602 Score = 487 bits (1254), Expect = e-138, Method: Composition-based stats. Identities = 159/464 (34%), Positives = 246/464 (53%), Gaps = 27/464 (5%) Query: 81 RRAAELGARAAVVE---------SHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGF 131 + AA+ GA+ AV++ + LGGTCVNVGC+PKK+M + S + D +G+ Sbjct: 130 KEAAKYGAKIAVLDYVEPTPMGTTWGLGGTCVNVGCIPKKLMHQAGLLSHSLEDAQHFGW 189 Query: 132 --PSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGK 189 E +W + E +++ LN Y+ +L + + + S + I K Sbjct: 190 SLDKSEISHDWSTMVEGVQSHIGSLNWGYKVSLRDNAVTYLNARGMLLSPHEVQITEKNK 249 Query: 190 ---KYTAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQLEELPGRSVIVGAGYIAVE 245 T I++ATG P P +IPGA GITSD F L PG++++VGA Y+A++ Sbjct: 250 KVSTITGNKIILATGERPKYP---EIPGAIEYGITSDDLFSLPYFPGKTLVVGASYVALK 306 Query: 246 MAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK----T 301 AG L++LG ++M+R +LR FD ++ + +EN GV+ K E+ + Sbjct: 307 CAGFLASLGGDVTVMVR-SILLRGFDQQMAEKVGDYMENHGVKFAKLCVPDEITQLKPVD 365 Query: 302 LSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDE 361 + ++ + + +++A+GR P L+ +G++ D G ++ + Sbjct: 366 TENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSKLNCEAVGVKLDKNGRVVCSD 425 Query: 362 FQNTNVKGIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP 420 + T V IYA+GD+ GK LTPVAI AGR LA RLF DY+N+ T VF+ Sbjct: 426 DEQTTVSNIYAIGDINAGKPQLTPVAIHAGRYLARRLFAGAT-ELTDYSNVATTVFTPLE 484 Query: 421 IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTK-CVMKMVCANKEE-KVVGIH 478 G GL+E++AI KYG +++ Y + F P+ V R+ C MK+VC + +V+G+H Sbjct: 485 YGACGLSEEDAIEKYGDNDIEVYHSHFKPLEWTVAHREDNVCYMKLVCRISDNMRVLGLH 544 Query: 479 MQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 522 + G E+ QG+AVA+KMGATK DFD T+ IHPT SE TL Sbjct: 545 VLGPNAGEITQGYAVAIKMGATKEDFDRTIGIHPTCSETFTTLH 588 >4KPR-E nrPDB Length = 499 Score = 484 bits (1246), Expect = e-137, Method: Composition-based stats. Identities = 154/459 (33%), Positives = 240/459 (52%), Gaps = 23/459 (5%) Query: 81 RRAAELGARAAVVE---------SHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGF 131 + AA+ + V++ LGGTCVNVGC+PKK+M A+ + + D +YG+ Sbjct: 29 KEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALKDSRNYGW 88 Query: 132 PS-CEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVS--- 187 K +W + E ++ LN Y+ L + + + F K + Sbjct: 89 KLEDTVKHDWEKMTESVQNHIGSLNWGYRVALREKKVVYENAYGKFIGPHKIMATNNKGK 148 Query: 188 GKKYTAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQLEELPGRSVIVGAGYIAVEM 246 K Y+A LIATG P IPG I+SD F L PG++++VGA Y+A+E Sbjct: 149 EKVYSAERFLIATGERPRY---LGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALEC 205 Query: 247 AGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLE 306 AG L+ +G ++M+R +LR FD ++ E +E G++ ++ ++++ +G Sbjct: 206 AGFLAGIGLDVTVMVR-SILLRGFDQDMANKIGEHMEEHGIKFIRQFVPTKIEQIEAGTP 264 Query: 307 VSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDK-GHIIVDEFQNT 365 + T+ + + +L A+GR T+ + L +G++ ++K G I V + + T Sbjct: 265 GRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTIGLETVGVKINEKTGKIPVTDEEQT 324 Query: 366 NVKGIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTV 424 NV IYA+GD+ GK LTPVAI AGR LA RL+ K DY+N+PT VF+ G Sbjct: 325 NVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYG-GSTVKCDYDNVPTTVFTPLEYGCC 383 Query: 425 GLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRK-TKCVMKMVCA-NKEEKVVGIHMQGL 482 GL+E++A+ K+G EN++ Y + F P+ V R KC K++C E+VVG H+ G Sbjct: 384 GLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNNKCYAKVICNLKDNERVVGFHVLGP 443 Query: 483 GCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTL 521 E+ QGFA A+K G TK D+T+ IHP +E TL Sbjct: 444 NAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTL 482 >2CFY-A nrPDB Length = 521 Score = 480 bits (1237), Expect = e-136, Method: Composition-based stats. Identities = 154/459 (33%), Positives = 241/459 (52%), Gaps = 23/459 (5%) Query: 81 RRAAELGARAAVVE---------SHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGF 131 + AA+ G + V++ LGGTCVNVGC+PKK+M A+ + + D +YG+ Sbjct: 51 KEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGW 110 Query: 132 PSCE-GKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVS--- 187 E K +W + E ++ LN Y+ L + + + F + + Sbjct: 111 KVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGK 170 Query: 188 GKKYTAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQLEELPGRSVIVGAGYIAVEM 246 K Y+A LIATG P IPG I+SD F L PG++++VGA Y+A+E Sbjct: 171 EKIYSAERFLIATGERPRY---LGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALEC 227 Query: 247 AGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLE 306 AG L+ +G ++M+R +LR FD ++ E +E G++ ++ +V++ +G Sbjct: 228 AGFLAGIGLDVTVMVR-SILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTP 286 Query: 307 VSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDK-GHIIVDEFQNT 365 + + + + ++ AIGR T+ + L +G++ ++K G I V + + T Sbjct: 287 GRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQT 346 Query: 366 NVKGIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTV 424 NV IYA+GD+ K LTPVAI AGR LA RL+ K DY N+PT VF+ G Sbjct: 347 NVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYA-GSTVKCDYENVPTTVFTPLEYGAC 405 Query: 425 GLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKT-KCVMKMVCANKE-EKVVGIHMQGL 482 GL+E++A+ K+G EN++ Y + F P+ + R KC K++C K+ E+VVG H+ G Sbjct: 406 GLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGP 465 Query: 483 GCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTL 521 E+ QGFA A+K G TK D+T+ IHP +E TL Sbjct: 466 NAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTL 504 >5W1J-A nrPDB Length = 584 Score = 479 bits (1233), Expect = e-135, Method: Composition-based stats. Identities = 167/481 (34%), Positives = 270/481 (56%), Gaps = 30/481 (6%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVE---------SHKLGGTCVNVGCVPKKVMW 114 YD ++IGGGSGGLA A+ +A+ GA+ A+++ + LGGTCVNVGC+PKK+M Sbjct: 103 DYDMVIIGGGSGGLALAKESAKSGAKVALLDFVVPTPMGTTWGLGGTCVNVGCIPKKLMH 162 Query: 115 NTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHA 174 A+ + +M D +G+ +G +W + E ++ LN Y++++ ++++ + Sbjct: 163 QAALLNHYMEDAKSFGWDVDKGPHDWVKMVEGIQDHIHALNFGYRSSMMNANVKYLNALG 222 Query: 175 AFTSDPKPTIEVSGKK-----YTAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQLE 228 TI+ + K+ T I++ATG P P IPGA GITSD F L+ Sbjct: 223 EIVDP--HTIKTTNKQGIVKNITTNTIIVATGERPRYP---PIPGAKEYGITSDDLFTLD 277 Query: 229 ELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVE 288 PG+++ VGA Y+++E AG LS++G ++M+R LR FD ++ ++ + GV+ Sbjct: 278 HNPGKTLCVGASYVSLECAGFLSSIGCDVTVMVR-SIFLRGFDQQMAGLISDYIAKYGVK 336 Query: 289 VLKFSQVKEV---KKTLSGLEVSMVTAVPGRLPVMTMIPD-VDCLLWAIGRVPNTKDLSL 344 ++ V ++ + V G+ T D + +L+A+GR P T ++ L Sbjct: 337 FVRPCVPTSVRCLEEYDPESGKLAIYEVEGKHEDGTPFKDTFNTVLFAVGRDPCTTNIGL 396 Query: 345 NKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCG-KALLTPVAIAAGRKLAHRLFEYKED 403 + ++T G ++VD+ + TNV IYA+GDV LTP+AI AG+ LA RL+ +D Sbjct: 397 QNVDVKTT-NGRVVVDDEERTNVPNIYAIGDVSNAGYQLTPLAIQAGKNLARRLY-TADD 454 Query: 404 SKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKR-KTKCV 462 + DY N+PT VF+ G +GL+E+ AI K+G +N++ + + F P+ V R C Sbjct: 455 CRTDYTNVPTTVFTPLEYGCIGLSEENAISKFGEDNIEVFHSYFQPLEWTVPHRPDNTCY 514 Query: 463 MKMVCANKEE-KVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTL 521 K++ +++ +VVG H+ G E+ QG+AVA+ +GA K DFD T+ IHPT SE TL Sbjct: 515 AKLIINKQDDNRVVGFHVFGPNAGEVTQGYAVAMHLGARKEDFDRTIGIHPTCSETFTTL 574 Query: 522 R 522 R Sbjct: 575 R 575 >2WOV-A nrPDB Length = 495 Score = 470 bits (1210), Expect = e-133, Method: Composition-based stats. Identities = 173/489 (35%), Positives = 257/489 (52%), Gaps = 38/489 (7%) Query: 58 AAGAVASYDYLVIGGGSGGLASARRAAE-LGARAAVVESH---------KLGGTCVNVGC 107 + ++D +VIG GSGGL + AA G R AVV+ LGGTCVNVGC Sbjct: 1 GSHMSKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGC 60 Query: 108 VPKKVMWNTAVHSEFMHDHADYGF--PSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTK- 164 VPKK+M A + + + + A +G+ K NW+ + ++ V +N Y+ Sbjct: 61 VPKKLMVTGAQYMDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDT 120 Query: 165 SHIEIIRGHAAFTSDPKPTIEVSG-------KKYTAPHILIATGGMPSTPHESQIPGASL 217 ++ G + S + + ++ A HIL+ATG P P IPG Sbjct: 121 EGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMP---AIPGIEH 177 Query: 218 GITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSAL---GSKTSLMIRHDKVLRSFDSMI 274 I+S+ F L E P R + VG G+I+VE AGI +A G K +L R++ +LR FD I Sbjct: 178 CISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDETI 237 Query: 275 STNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIG 334 T++L G+E++ +V G VT G+ DVD ++ AIG Sbjct: 238 REEVTKQLTANGIEIMTNENPAKVSLNTDGS--KHVTFESGK------TLDVDVVMMAIG 289 Query: 335 RVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLA 394 R+P T DL L +G++ KG + VDEF TNV IYA+GD+ + +LTPVAI G L Sbjct: 290 RIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALV 349 Query: 395 HRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAV 454 +F K K D+ + + VFS PPIGT GL E+ A ++ E V Y +SFTP+ H + Sbjct: 350 DTVFGNKP-RKTDHTRVASAVFSIPPIGTCGLIEEVAAKEF--EKVAVYMSSFTPLMHNI 406 Query: 455 TKRKTKCVM-KMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPT 513 + K K + K+V + + V+G+H+ G G E++Q V +++ A +DF NT+ +HPT Sbjct: 407 SGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPT 466 Query: 514 SSEELVTLR 522 S+EEL ++R Sbjct: 467 SAEELCSMR 475 >5J5Z-A nrPDB Length = 496 Score = 466 bits (1199), Expect = e-131, Method: Composition-based stats. Identities = 139/474 (29%), Positives = 223/474 (47%), Gaps = 25/474 (5%) Query: 57 PAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKKVMWN 115 P A D VIG G GG +A +AA+LG + +E ++ LGGTC+NVGC+P K + N Sbjct: 21 PGADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLN 80 Query: 116 TAVHSEFMH--DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGH 173 + + H D A G E + N + E++ V L + ++ + + G+ Sbjct: 81 NSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGY 140 Query: 174 AAFTSDPKPTIE---VSGKKYTAPHILIATGGMPSTPHESQIPGASLG----ITSDGFFQ 226 T + T + +ILIATG + PG ++ ++S G Sbjct: 141 GKITGKNQVTATKADGGTQVIDTKNILIATGS-----EVTPFPGITIDEDTIVSSTGALS 195 Query: 227 LEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLR-SFDSMISTNCTEELENA 285 L+++P + V++GAG I VE+ + LG+ + + V D IS N L+ Sbjct: 196 LKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQ 255 Query: 286 GVEVLKFSQVKEVKKTLSG-LEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSL 344 G + ++V K G ++VS+ A G+ V+T D LL IGR P TK+L L Sbjct: 256 GFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVIT----CDVLLVCIGRRPFTKNLGL 311 Query: 345 NKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDS 404 +LGI+ D +G I V+ T + IYA+GDV +L A G + Sbjct: 312 EELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAV-- 369 Query: 405 KLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMK 464 +DYN +P+V+++HP + VG +E++ + + GIE K F A T T ++K Sbjct: 370 HIDYNCVPSVIYTHPEVAWVGKSEEQ-LKEEGIE-YKVGKFPFAANSRAKTNADTDGMVK 427 Query: 465 MVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 ++ ++V+G H+ G G EM+ A+A++ GA+ HPT SE Sbjct: 428 ILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEVIARVCHAHPTLSEAF 481 >4B1B-A nrPDB Length = 542 Score = 464 bits (1194), Expect = e-131, Method: Composition-based stats. Identities = 161/492 (32%), Positives = 237/492 (48%), Gaps = 47/492 (9%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVE---------SHKLGGTCVNVGCVPKKVMW 114 YDY+VIGGG GG+ASA+ AA GAR + + +GGTCVNVGCVPKK+M Sbjct: 42 DYDYVVIGGGPGGMASAKEAAAHGARVLLFDYVKPSSQGTKWGIGGTCVNVGCVPKKLMH 101 Query: 115 NTAVHSEFMH-DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGH 173 D YG+ K +W+ + +++ LN Y L S ++ I G Sbjct: 102 YAGHMGSIFKLDSKAYGWKFDNLKHDWKKLVTTVQSHIRSLNFSYMTGLRSSKVKYINGL 161 Query: 174 AAFTSDPKPTIEVSG-----KKYTAPHILIATGGMPSTPHESQIPGA-SLGITSDGFFQL 227 A + + G + T +ILIATG P P + GA L ITSD F L Sbjct: 162 AKLKDKNTVSYYLKGDLSKEETVTGKYILIATGCRPHIPD--DVEGAKELSITSDDIFSL 219 Query: 228 EELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGV 287 ++ PG++++VGA Y+A+E +G L++LG ++ +R VLR FD + +E GV Sbjct: 220 KKDPGKTLVVGASYVALECSGFLNSLGYDVTVAVR-SIVLRGFDQQCAVKVKLYMEEQGV 278 Query: 288 EVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKL 347 K++ K + V D +L+AIGR + L+L L Sbjct: 279 MFKNGILPKKLTKMDDKILVEFSDKTS---------ELYDTVLYAIGRKGDIDGLNLESL 329 Query: 348 GIQTDD-KGHIIVDEFQNTNVKGIYAVGDVCGK-ALLTPVAIAAGRKLAHRLFEYKEDSK 405 + + II D TN+ I+AVGDV L PVAI AG LA RLF+ D Sbjct: 330 NMNVNKSNNKIIADHLSCTNIPSIFAVGDVAENVPELAPVAIKAGEILARRLFK-DSDEI 388 Query: 406 LDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTK----- 460 +DY+ IPT +++ G G +E++A YG NV+ + F + + R+ Sbjct: 389 MDYSYIPTSIYTPIEYGACGYSEEKAYELYGKSNVEVFLQEFNNLEISAVHRQKHIRAQK 448 Query: 461 ----------CVMKMVC-ANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVA 509 C+ K+VC N++ +V+G H G E+ QG A+A+++ K DFDN + Sbjct: 449 DEYDLDVSSTCLAKLVCLKNEDNRVIGFHYVGPNAGEVTQGMALALRLKVKKKDFDNCIG 508 Query: 510 IHPTSSEELVTL 521 IHPT +E + L Sbjct: 509 IHPTDAESFMNL 520 >2NVK-X nrPDB Length = 488 Score = 464 bits (1194), Expect = e-131, Method: Composition-based stats. Identities = 167/476 (35%), Positives = 250/476 (52%), Gaps = 28/476 (5%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVE----------SHKLGGTCVNVGCVPKKVM 113 YD +VIGGGS GLA A+ A GAR A ++ +GGTCVNVGC+PKK+M Sbjct: 9 DYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKKLM 68 Query: 114 WNTAVHSEFMHDHADYGFPSCEG-KFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRG 172 ++ E +H+ A YG+ + K +W + + ++ +N + + +L +E I G Sbjct: 69 HQASLLGEAVHEAAAYGWNVDDKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYING 128 Query: 173 HAAFTSDPKPT--IEVSGKKYTAPHILIATGGMPSTPHESQIPG-ASLGITSDGFFQLEE 229 +F ++ + TA +IA GG P P IPG GITSD F L+ Sbjct: 129 LGSFVDSHTLLAKLKSGERTITAQTFVIAVGGRPRYP---DIPGAVEYGITSDDLFSLDR 185 Query: 230 LPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEV 289 PG++++VGAGYI +E AG L LG + ++M+R VLR FD ++ +E G+ Sbjct: 186 EPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVR-SIVLRGFDQQMAELVAASMEERGIPF 244 Query: 290 LKFSQVKEVKKTLSG-LEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLG 348 L+ + V+K G L V G D +LWAIGR DL+L G Sbjct: 245 LRKTVPLSVEKQDDGKLLVKYKNVETGEESEDV----YDTVLWAIGRKGLVDDLNLPNAG 300 Query: 349 IQTDDKGHIIVDEFQNTNVKGIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSKLD 407 + K I VD + TNV IYAVGD+ GK LTPVA+ AGR LA RL+ ++D Sbjct: 301 VTV-QKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYG-GSTQRMD 358 Query: 408 YNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTK-CVMKMV 466 Y ++ T VF+ VGL+E++A+ ++G + ++ + + P + ++ + C +K V Sbjct: 359 YKDVATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKAV 418 Query: 467 C-ANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTL 521 + +++V G+H G E++QGFA A+K G T NTV IHPT++EE L Sbjct: 419 AERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRL 474 >2YAU-A nrPDB Length = 511 Score = 462 bits (1190), Expect = e-130, Method: Composition-based stats. Identities = 165/491 (33%), Positives = 246/491 (50%), Gaps = 38/491 (7%) Query: 56 PPAAGAVASYDYLVIGGGSGGLASARRAA-ELGARAAVVESHK---------LGGTCVNV 105 P + +YD +V+G GSGGL + AA + AVV+ LGGTCVNV Sbjct: 16 PRGSHMSRAYDLVVLGAGSGGLEAGWNAAVTHKKKVAVVDVQATHGPPLFAALGGTCVNV 75 Query: 106 GCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKF--NWRVIKEKRDAYVSRLNAIYQNNLT 163 GCVPKK+M A + + + + +G+ NW+ + ++ V+ +N Y++ Sbjct: 76 GCVPKKLMVTGAQYMDLIRESGGFGWEMDRESLCPNWKTLIAAKNKVVNSINESYKSMFA 135 Query: 164 K-SHIEIIRGHAAFTSDPKPTIEVSG-------KKYTAPHILIATGGMPSTPHESQIPGA 215 + G A + S + +ILIATG P +PG Sbjct: 136 DTEGLSFHMGFGALQDAHTVVVRKSEDPHSDVLETLDTEYILIATGS---WPTRLGVPGD 192 Query: 216 SLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSAL---GSKTSLMIRHDKVLRSFDS 272 ITS+ F LE+ P R + VG GYIAVE AGI + G L R D +LR FD+ Sbjct: 193 EFCITSNEAFYLEDAPKRMLCVGGGYIAVEFAGIFNGYKPCGGYVDLCYRGDLILRGFDT 252 Query: 273 MISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWA 332 + + T++L G+ V ++ K G V G D D ++ A Sbjct: 253 EVRKSLTKQLGANGIRVRTNLNPTKITKNEDGSN--HVHFNDGTEE------DYDQVMLA 304 Query: 333 IGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRK 392 IGRVP ++ L L+K G++T G + VD + T+V IYA+GDV + +LTPVAI G Sbjct: 305 IGRVPRSQALQLDKAGVRTGKNGAVQVDAYSKTSVDNIYAIGDVTNRVMLTPVAINEGAA 364 Query: 393 LAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYH 452 +F K + D+ + VFS PPIGT G+TE+EA Y E V Y++SFTP+ H Sbjct: 365 FVETVFGGKPRAT-DHTKVACAVFSIPPIGTCGMTEEEAAKNY--ETVAVYASSFTPLMH 421 Query: 453 AVTKRKTKCVM-KMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIH 511 ++ K K M +++ +V+G+HM G E++Q + +KMGA +DF +T+ +H Sbjct: 422 NISGSKHKEFMIRIITNESNGEVLGVHMLGDSAPEIIQSVGICMKMGAKISDFHSTIGVH 481 Query: 512 PTSSEELVTLR 522 PTS+EEL ++R Sbjct: 482 PTSAEELCSMR 492 >1FEC-A nrPDB Length = 490 Score = 460 bits (1183), Expect = e-130, Method: Composition-based stats. Identities = 167/483 (34%), Positives = 245/483 (50%), Gaps = 38/483 (7%) Query: 64 SYDYLVIGGGSGGLASARRAAE-LGARAAVVESHK---------LGGTCVNVGCVPKKVM 113 +YD +VIG GSGGL + AA R AV++ K LGGTCVNVGCVPKK+M Sbjct: 3 AYDLVVIGAGSGGLEAGWNAASLHKKRVAVIDLQKHHGPPHYAALGGTCVNVGCVPKKLM 62 Query: 114 WNTAVHSEFMHDHADYGFPSCEGKF--NWRVIKEKRDAYVSRLNAIYQNNLTK-SHIEII 170 A + + + + A +G+ NW+ + ++ VS +N Y+ + Sbjct: 63 VTGANYMDTIRESAGFGWELDRESVRPNWKALIAAKNKAVSGINDSYEGMFADTEGLTFH 122 Query: 171 RGHAAFTSDPKPTIEVSG-------KKYTAPHILIATGGMPSTPHESQIPGASLGITSDG 223 +G A + + S + +IL+ATG P I G L ITS+ Sbjct: 123 QGFGALQDNHTVLVRESADPNSAVLETLDTEYILLATGS---WPQHLGIEGDDLCITSNE 179 Query: 224 FFQLEELPGRSVIVGAGYIAVEMAGILSAL---GSKTSLMIRHDKVLRSFDSMISTNCTE 280 F L+E P R++ VG GYI++E AGI +A G + L R D +LR FDS + TE Sbjct: 180 AFYLDEAPKRALCVGGGYISIEFAGIFNAYKARGGQVDLAYRGDMILRGFDSELRKQLTE 239 Query: 281 ELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTK 340 +L G+ V +V K G + D D ++ AIGRVP ++ Sbjct: 240 QLRANGINVRTHENPAKVTKNADGTRHVVF--------ESGAEADYDVVMLAIGRVPRSQ 291 Query: 341 DLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEY 400 L L K G++ G I VD + TNV IYA+GDV + +LTPVAI G +F Sbjct: 292 TLQLEKAGVEVAKNGAIKVDAYSKTNVDNIYAIGDVTDRVMLTPVAINEGAAFVDTVFAN 351 Query: 401 KEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTK 460 K + D+ + VFS PP+G G E++A KY + V Y +SFTP+ H ++ K Sbjct: 352 KPRAT-DHTKVACAVFSIPPMGVCGYVEEDAAKKY--DQVAVYESSFTPLMHNISGSTYK 408 Query: 461 CVM-KMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELV 519 M ++V + + +V+G+HM G E++Q A+ +KMGA +DF NT+ +HPTS+EEL Sbjct: 409 KFMVRIVTNHADGEVLGVHMLGDSSPEIIQSVAICLKMGAKISDFYNTIGVHPTSAEELC 468 Query: 520 TLR 522 ++R Sbjct: 469 SMR 471 >4NEW-A nrPDB Length = 492 Score = 459 bits (1180), Expect = e-129, Method: Composition-based stats. Identities = 168/482 (34%), Positives = 244/482 (50%), Gaps = 39/482 (8%) Query: 65 YDYLVIGGGSGGLASARRAAE-LGARAAVVESH---------KLGGTCVNVGCVPKKVMW 114 +D +VIG GSGGL +A AA R AV++ LGGTCVNVGCVPKK+M Sbjct: 6 FDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVGCVPKKLMV 65 Query: 115 NTAVHSEFMHDHADYGFPSCEGKF--NWRVIKEKRDAYVSRLNAIYQNNLTK-SHIEIIR 171 A + E + + A +G+ W+ + +D V +N Y +E Sbjct: 66 TGAQYMEHLRESAGFGWEFDRTTLRAEWKNLIAVKDEAVLNINKSYDEMFRDTEGLEFFL 125 Query: 172 GHAAFTSDPKPTIEVSG-------KKYTAPHILIATGGMPSTPHESQIPGASLGITSDGF 224 G + S + S ++ HIL+A+G P P IPG I+S+ Sbjct: 126 GWGSLESKNVVNVRESADPASAVKERLETEHILLASGSWPHMP---NIPGIEHCISSNEA 182 Query: 225 FQLEELPGRSVIVGAGYIAVEMAGILSALGSK---TSLMIRHDKVLRSFDSMISTNCTEE 281 F L E P R + VG G+I+VE AGI +A K +L R + +LR FD + T++ Sbjct: 183 FYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREELTKQ 242 Query: 282 LENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKD 341 L G+++L +V+ G VT G+ D D ++ AIGR P TKD Sbjct: 243 LTANGIQILTKENPAKVELNADGS--KSVTFESGKK------MDFDLVMMAIGRSPRTKD 294 Query: 342 LSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYK 401 L L G+ G + VDE+ TNV IYA+GDV + +LTPVAI L +F Sbjct: 295 LQLQNAGVMI-KNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTVFGT- 352 Query: 402 EDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKC 461 K D+ + + VFS PPIGT GL E+ A +Y E V Y +SFTP+ H V+ K K Sbjct: 353 TPRKTDHTRVASAVFSIPPIGTCGLIEEVASKRY--EVVAVYLSSFTPLMHKVSGSKYKT 410 Query: 462 VM-KMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVT 520 + K++ + + V+G+H+ G E++QG + +K+ A +DF NT+ +HPTS+EEL + Sbjct: 411 FVAKIITNHSDGTVLGVHLLGDNAPEIIQGIGICLKLNAKISDFYNTIGVHPTSAEELCS 470 Query: 521 LR 522 +R Sbjct: 471 MR 472 >5U8W-A nrPDB Length = 481 Score = 456 bits (1173), Expect = e-128, Method: Composition-based stats. Identities = 121/472 (25%), Positives = 226/472 (47%), Gaps = 22/472 (4%) Query: 58 AAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESH-------KLGGTCVNVGCVPK 110 + +D +VIG G GG +A RAA+LG + A +E + LGGTC+NVGC+P Sbjct: 1 GSHMSQKFDVVVIGAGPGGYVAAIRAAQLGLKTACIEKYIGKEGKVALGGTCLNVGCIPS 60 Query: 111 KVMWNTA-VHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEI 169 K + +++ + E +G + + + ++ V L + + Sbjct: 61 KALLDSSYKYHEAKEAFKVHGIEAKGVTIDVPAMVARKANIVKNLTGGIATLFKANGVTS 120 Query: 170 IRGHAAFTSDPKPTIEV---SGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQ 226 GH ++ + + + A +++IA+G P + + + + S G + Sbjct: 121 FEGHGKLLANKQVEVTGLDGKTQVLEAENVIIASGSRPVEIPPAPLT-DDIIVDSTGALE 179 Query: 227 LEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAG 286 + +P + ++GAG I +E+ + + LG++ +++ DK L + D I+ + L G Sbjct: 180 FQAVPKKLGVIGAGVIGLELGSVWARLGAEVTVLEALDKFLPAADEQIAKEALKVLTKQG 239 Query: 287 VEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNK 346 + + ++V + + V+ A + D L+ A+GR P T DL Sbjct: 240 LNIRLGARVTASEVKKKQVTVTFTDANGEQKET------FDKLIVAVGRRPVTTDLLAAD 293 Query: 347 LGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKL 406 G+ D++G I VD+ T+V G++A+GDV A+L A G +A R+ +K +++ Sbjct: 294 SGVTLDERGFIYVDDHCKTSVPGVFAIGDVVRGAMLAHKASEEGVMVAERIAGHK--AQM 351 Query: 407 DYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMV 466 +Y+ IP+V+++HP I VG TE + + G+E V + F A+ T ++K++ Sbjct: 352 NYDLIPSVIYTHPEIAWVGKTE-QTLKAEGVE-VNVGTFPFAASGRAMAANDTTGLVKVI 409 Query: 467 CANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 K ++V+G+H+ G E++Q A+ ++ G + D V HPT SE L Sbjct: 410 ADAKTDRVLGVHVIGPSAAELVQQGAIGMEFGTSAEDLGMMVFSHPTLSEAL 461 >3URH-A nrPDB Length = 491 Score = 456 bits (1173), Expect = e-128, Method: Composition-based stats. Identities = 129/469 (27%), Positives = 219/469 (46%), Gaps = 24/469 (5%) Query: 61 AVASYDYLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVNVGCVPKKVMWNTAVH 119 ++ +YD +VIG G GG A +AA+LG + AVVE GGTC+NVGC+P K + + + Sbjct: 22 SMMAYDLIVIGSGPGGYVCAIKAAQLGMKVAVVEKRSTYGGTCLNVGCIPSKALLHASEM 81 Query: 120 SEFM-HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTS 178 H G K N + + +DA V K+ I+ +G Sbjct: 82 FHQAQHGLEALGVEVANPKLNLQKMMAHKDATVKSNVDGVSFLFKKNKIDGFQGTGKVLG 141 Query: 179 DPKPTI---EVSGKKYTAPHILIATGGMPSTPHESQIPGASLG------ITSDGFFQLEE 229 K ++ + + A +++IATG + IPG + ++S G LE+ Sbjct: 142 QGKVSVTNEKGEEQVLEAKNVVIATGS-----DVAGIPGVEVAFDEKTIVSSTGALALEK 196 Query: 230 LPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEV 289 +P ++VG G I +E+ + + LG+K +++ D +L D ++ L G++ Sbjct: 197 VPASMIVVGGGVIGLELGSVWARLGAKVTVVEFLDTILGGMDGEVAKQLQRMLTKQGIDF 256 Query: 290 LKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGI 349 ++V K+ G +V+ G D + +L A GR P+T L L K G+ Sbjct: 257 KLGAKVTGAVKSGDGAKVTFEPVKGGEATT----LDAEVVLIATGRKPSTDGLGLAKAGV 312 Query: 350 QTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYN 409 D +G + +D T++ G+YA+GDV +L A G +A + + ++Y+ Sbjct: 313 VLDSRGRVEIDRHFQTSIAGVYAIGDVVRGPMLAHKAEDEGVAVAEIIAG--QAGHVNYD 370 Query: 410 NIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCAN 469 IP VV++ P + +VG TE+E + G+ K FT A +T +K++ Sbjct: 371 VIPGVVYTQPEVASVGKTEEE-LKAAGV-AYKIGKFPFTANGRARAMLQTDGFVKILADK 428 Query: 470 KEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 + ++V+G H+ G G EM+ AV ++ G + D T HPT SE + Sbjct: 429 ETDRVLGGHIIGFGAGEMIHEIAVLMEFGGSSEDLGRTCHAHPTMSEAV 477 >5TR3-A nrPDB Length = 481 Score = 453 bits (1166), Expect = e-128, Method: Composition-based stats. Identities = 127/472 (26%), Positives = 238/472 (50%), Gaps = 23/472 (4%) Query: 59 AGAVAS-YDYLVIGGGSGGLASARRAAELGARAAVVESH-------KLGGTCVNVGCVPK 110 + A+ +D +VIG G GG +A +AA+LG + A +E + LGGTC+NVGC+P Sbjct: 1 SNAMTQKFDVVVIGAGPGGYVAAIKAAQLGLKTACIEKYTDAEGKLALGGTCLNVGCIPS 60 Query: 111 KVMWNTA-VHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEI 169 K + +++ + E +G + E K + + ++ V L + + Sbjct: 61 KALLDSSWKYKEAKESFNVHGISTGEVKMDVAAMVGRKAGIVKNLTGGVATLFKANGVTS 120 Query: 170 IRGHAAFTSDPKPTIE---VSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQ 226 I+GH + K + + + A ++++A+G P + + ++ + S G + Sbjct: 121 IQGHGKLLAGKKVEVTKADGTTEVIEAENVILASGSRPIDIPPAPVD-QNVIVDSTGALE 179 Query: 227 LEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAG 286 + +P R ++GAG I +E+ + + LG++ +++ D L + D+ +S + L G Sbjct: 180 FQAVPKRLGVIGAGVIGLELGSVWARLGAEVTVLEALDTFLMAADTAVSKEAQKTLTKQG 239 Query: 287 VEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNK 346 +++ ++V K + +EV+ A + D L+ A+GR P T DL + Sbjct: 240 LDIKLGARVTGSKVNGNEVEVTYTNAEGEQKIT------FDKLIVAVGRRPVTTDLLASD 293 Query: 347 LGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKL 406 G+ D++G+I VD++ T+V G+YA+GDV +L A G + R+ +K +++ Sbjct: 294 SGVTIDERGYIFVDDYCATSVPGVYAIGDVVRGMMLAHKASEEGIMVVERIKGHK--AQM 351 Query: 407 DYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMV 466 +Y+ IP+V+++HP I VG TE +A+ G+E V + F A+ T +K++ Sbjct: 352 NYDLIPSVIYTHPEIAWVGKTE-QALKAEGVE-VNVGTFPFAASGRAMAANDTGGFVKVI 409 Query: 467 CANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 K ++V+G+H+ G E++Q A+A++ G + D V HPT SE L Sbjct: 410 ADAKTDRVLGVHVIGPSAAELVQQGAIAMEFGTSAEDLGMMVFSHPTLSEAL 461 >1EBD-A nrPDB Length = 455 Score = 451 bits (1160), Expect = e-127, Method: Composition-based stats. Identities = 125/451 (27%), Positives = 214/451 (47%), Gaps = 14/451 (3%) Query: 68 LVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHA 127 LV+G G GG +A RAA+LG + +VE LGG C+NVGC+P K + + + E Sbjct: 7 LVVGAGPGGYVAAIRAAQLGQKVTIVEKGNLGGVCLNVGCIPSKALISASHRYEQAKHSE 66 Query: 128 DYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIE-- 185 + G + ++ ++E + + V +L + L + +EI++G A F + Sbjct: 67 EMGIKAENVTIDFAKVQEWKASVVKKLTGGVEGLLKGNKVEIVKGEAYFVDANTVRVVNG 126 Query: 186 VSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVE 245 S + YT + +IATG P ++ + S G L E+P V++G GYI +E Sbjct: 127 DSAQTYTFKNAIIATGSRPI--ELPNFKFSNRILDSTGALNLGEVPKSLVVIGGGYIGIE 184 Query: 246 MAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGL 305 + + G+K +++ ++L F+ ++ + L+ GVEV+ + K ++ G+ Sbjct: 185 LGTAYANFGTKVTILEGAGEILSGFEKQMAAIIKKRLKKKGVEVVTNALAKGAEEREDGV 244 Query: 306 EVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNT 365 V+ T D D +L +GR PNT +L L ++GI+ ++G I VD+ T Sbjct: 245 TVTY------EANGETKTIDADYVLVTVGRRPNTDELGLEQIGIKMTNRGLIEVDQQCRT 298 Query: 366 NVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVG 425 +V I+A+GD+ L A G+ A + + +DY IP VVFS P +VG Sbjct: 299 SVPNIFAIGDIVPGPALAHKASYEGKVAAEAIAGHPSA--VDYVAIPAVVFSDPECASVG 356 Query: 426 LTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCD 485 E +A GI+ + F A+ T +K+V ++ ++G + G Sbjct: 357 YFEQQA-KDEGIDVIAA-KFPFAANGRALALNDTDGFLKLVVRKEDGVIIGAQIIGPNAS 414 Query: 486 EMLQGFAVAVKMGATKADFDNTVAIHPTSSE 516 +M+ +A++ G T D T+ HPT E Sbjct: 415 DMIAELGLAIEAGMTAEDIALTIHAHPTLGE 445 >3LAD-A nrPDB Length = 476 Score = 448 bits (1154), Expect = e-126, Method: Composition-based stats. Identities = 124/465 (26%), Positives = 231/465 (49%), Gaps = 22/465 (4%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHK-------LGGTCVNVGCVPKKVMWNTA 117 +D +VIG G GG +A ++A+LG + A++E +K LGGTC+NVGC+P K + +++ Sbjct: 4 FDVIVIGAGPGGYVAAIKSAQLGLKTALIEKYKGKEGKTALGGTCLNVGCIPSKALLDSS 63 Query: 118 VHSEFMHDHAD-YGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAF 176 H+ +G + E + + ++D V L + + + + + GH Sbjct: 64 YKFHEAHESFKLHGISTGEVAIDVPTMIARKDQIVRNLTGGVASLIKANGVTLFEGHGKL 123 Query: 177 TSDPKPTIE---VSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGR 233 + K + S + ++++A+G P + + + + S G + +PG+ Sbjct: 124 LAGKKVEVTAADGSSQVLDTENVILASGSKPVEIPPAPVD-QDVIVDSTGALDFQNVPGK 182 Query: 234 SVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFS 293 ++GAG I +E+ + + LG++ +++ DK L + D ++ + L G+++L + Sbjct: 183 LGVIGAGVIGLELGSVWARLGAEVTVLEAMDKFLPAVDEQVAKEAQKILTKQGLKILLGA 242 Query: 294 QVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDD 353 +V + + V V A + D L+ A+GR P T DL G+ D+ Sbjct: 243 RVTGTEVKNKQVTVKFVDAEGEKSQA------FDKLIVAVGRRPVTTDLLAADSGVTLDE 296 Query: 354 KGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPT 413 +G I VD++ T+V G+YA+GDV A+L A G +A R+ +K ++++Y+ IP Sbjct: 297 RGFIYVDDYCATSVPGVYAIGDVVRGAMLAHKASEEGVVVAERIAGHK--AQMNYDLIPA 354 Query: 414 VVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEK 473 V+++HP I VG TE +A+ G+ + F A+ T +K++ K ++ Sbjct: 355 VIYTHPEIAGVGKTE-QALKAEGV-AINVGVFPFAASGRAMAANDTAGFVKVIADAKTDR 412 Query: 474 VVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 V+G+H+ G E++Q A+A++ G + D V HP SE L Sbjct: 413 VLGVHVIGPSAAELVQQGAIAMEFGTSAEDLGMMVFAHPALSEAL 457 >1DXL-A nrPDB Length = 470 Score = 448 bits (1152), Expect = e-126, Method: Composition-based stats. Identities = 131/470 (27%), Positives = 241/470 (51%), Gaps = 23/470 (4%) Query: 58 AAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVES-HKLGGTCVNVGCVPKKVMWNT 116 A+G+ + D ++IGGG GG +A +AA+LG + +E LGGTC+NVGC+P K + ++ Sbjct: 1 ASGSDEN-DVVIIGGGPGGYVAAIKAAQLGFKTTCIEKRGALGGTCLNVGCIPSKALLHS 59 Query: 117 AV-HSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAA 175 + + E H A++G + + + ++D VS L + K+ + ++G+ Sbjct: 60 SHMYHEAKHSFANHGVKVSNVEIDLAAMMGQKDKAVSNLTRGIEGLFKKNKVTYVKGYGK 119 Query: 176 FTSDPKP---TIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLG----ITSDGFFQLE 228 F S + TIE HI+IATG +PG ++ ++S G L Sbjct: 120 FVSPSEISVDTIEGENTVVKGKHIIIATGS-----DVKSLPGVTIDEKKIVSSTGALALS 174 Query: 229 ELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVE 288 E+P + V++GAGYI +EM + +GS+ +++ +++ + D+ I LE G++ Sbjct: 175 EIPKKLVVIGAGYIGLEMGSVWGRIGSEVTVVEFASEIVPTMDAEIRKQFQRSLEKQGMK 234 Query: 289 VLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLG 348 ++V V + G+++++ + G I + D +L + GR P T L+L+K+G Sbjct: 235 FKLKTKVVGVDTSGDGVKLTVEPSAGGEQT----IIEADVVLVSAGRTPFTSGLNLDKIG 290 Query: 349 IQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDY 408 ++TD G I+V+E +TNV G+YA+GDV +L A G L +DY Sbjct: 291 VETDKLGRILVNERFSTNVSGVYAIGDVIPGPMLAHKAEEDGVACVEYLAGKV--GHVDY 348 Query: 409 NNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCA 468 + +P VV+++P + +VG TE++ + + G+E + F A + ++K++ Sbjct: 349 DKVPGVVYTNPEVASVGKTEEQ-VKETGVE-YRVGKFPFMANSRAKAIDNAEGLVKIIAE 406 Query: 469 NKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 + +K++G+H+ E++ A+A++ A+ D HPT SE + Sbjct: 407 KETDKILGVHIMAPNAGELIHEAAIALQYDASSEDIARVCHAHPTMSEAI 456 >2YQU-A nrPDB Length = 455 Score = 447 bits (1150), Expect = e-126, Method: Composition-based stats. Identities = 136/456 (29%), Positives = 213/456 (46%), Gaps = 16/456 (3%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKKVMWNTAVHSEF 122 YD LVIG G GG +A RAA+LG + VVE K LGGTC+ VGC+P K + T Sbjct: 1 MYDLLVIGAGPGGYVAAIRAAQLGMKVGVVEKEKALGGTCLRVGCIPSKALLETTERIYE 60 Query: 123 MHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKP 182 G + + + +D V + K+ I +G A F S+ K Sbjct: 61 AKK-GLLGAKVKGVELDLPALMAHKDKVVQANTQGVEFLFKKNGIARHQGTARFLSERKV 119 Query: 183 TIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYI 242 +E +G++ A +ILIATG P P +Q+ + +TS E+P R ++VG G I Sbjct: 120 LVEETGEELEARYILIATGSAPLIPPWAQVDYERV-VTSTEALSFPEVPKRLIVVGGGVI 178 Query: 243 AVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTL 302 +E+ + LG++ ++ D++L + D +S + G+ + +V V Sbjct: 179 GLELGVVWHRLGAEVIVLEYMDRILPTMDLEVSRAAERVFKKQGLTIRTGVRVTAVVPEA 238 Query: 303 SGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEF 362 G V + + + D +L A+GR P T+ LSL G+ TD++G I VDE Sbjct: 239 KGARVELEGGE---------VLEADRVLVAVGRRPYTEGLSLENAGLSTDERGRIPVDEH 289 Query: 363 QNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIG 422 T V IYA+GDV +L A G + +DY IP+VV++HP I Sbjct: 290 LRTRVPHIYAIGDVVRGPMLAHKASEEGIAAVEHMVRGF--GHVDYQAIPSVVYTHPEIA 347 Query: 423 TVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGL 482 VG TE+E + GI K ++ A +T+ +K++ K ++++G+H G Sbjct: 348 AVGYTEEE-LKAQGI-PYKVGKFPYSASGRARAMGETEGFIKVLAHAKTDRILGVHGIGA 405 Query: 483 GCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 ++L A+A+ A+ D HP+ SE L Sbjct: 406 RVGDVLAEAALALFFKASAEDLGRAPHAHPSLSEIL 441 >1V59-A nrPDB Length = 478 Score = 444 bits (1142), Expect = e-125, Method: Composition-based stats. Identities = 133/472 (28%), Positives = 223/472 (47%), Gaps = 27/472 (5%) Query: 63 ASYDYLVIGGGSGGLASARRAAELGARAAVVES-HKLGGTCVNVGCVPKKVMWNTAVHSE 121 S+D ++IGGG G +A +AA+LG A VE KLGGTC+NVGC+P K + N + Sbjct: 4 KSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFH 63 Query: 122 FMHDHADY-GFPS-CEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSD 179 MH A G + K N ++ +D V +L + K+ + +G+ +F + Sbjct: 64 QMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDE 123 Query: 180 PKPTIE-VSGKK--------YTAPHILIATGGMPSTPHESQIPGASLG----ITSDGFFQ 226 K + V G + +I++ATG + PG + ++S G Sbjct: 124 TKIRVTPVDGLEGTVKEDHILDVKNIIVATGS-----EVTPFPGIEIDEEKIVSSTGALS 178 Query: 227 LEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAG 286 L+E+P R I+G G I +EM + S LGSK +++ ++ S D ++ + L+ G Sbjct: 179 LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQG 238 Query: 287 VEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNK 346 ++ ++V K+ V +V + + LL A+GR P L K Sbjct: 239 LDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQEN--LEAEVLLVAVGRRPYIAGLGAEK 296 Query: 347 LGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKL 406 +G++ D +G +++D+ N+ I VGDV +L A G L + Sbjct: 297 IGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEML--KTGHGHV 354 Query: 407 DYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMV 466 +YNNIP+V++SHP + VG TE++ + + GI+ K F A T + T+ +K++ Sbjct: 355 NYNNIPSVMYSHPEVAWVGKTEEQ-LKEAGID-YKIGKFPFAANSRAKTNQDTEGFVKIL 412 Query: 467 CANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 +K E+++G H+ G EM+ +A++ GA+ D HPT SE Sbjct: 413 IDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAF 464 >4DNA-A nrPDB Length = 463 Score = 442 bits (1137), Expect = e-124, Method: Composition-based stats. Identities = 176/458 (38%), Positives = 248/458 (54%), Gaps = 13/458 (2%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFM 123 YD VIGGGSGG+ S R AA LG + A+ E + GGTCV GCVPKK+ + +E Sbjct: 5 DYDLFVIGGGSGGVRSGRLAAALGKKVAIAEEFRYGGTCVIRGCVPKKLYVYASQFAEHF 64 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 D A +G+ E +F+W + ++ ++RL +Y+ L + EI+ A Sbjct: 65 EDAAGFGWTVGESRFDWAKLVAAKEQEIARLEGLYRKGLANAGAEILDTRAELAGPNTVK 124 Query: 184 IEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIA 243 + SGK TA I+IA GG PS +PG L ITS+ F L LP +I G GYIA Sbjct: 125 LLASGKTVTAERIVIAVGGHPS--PHDALPGHELCITSNEAFDLPALPESILIAGGGYIA 182 Query: 244 VEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLS 303 VE A I LG KT+L+ R ++L FD + +E G+ +L ++ V Sbjct: 183 VEFANIFHGLGVKTTLIYRGKEILSRFDQDMRRGLHAAMEEKGIRILCEDIIQSVSADAD 242 Query: 304 GLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQ 363 G V T G + D ++ A+GR+PNT L L G++T++ G IIVD F Sbjct: 243 GRRV-ATTMKHGEIV-------ADQVMLALGRMPNTNGLGLEAAGVRTNELGAIIVDAFS 294 Query: 364 NTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGT 423 T+ GIYA+GDV + LTPVAI ++ S D++ I T VFS P IGT Sbjct: 295 RTSTPGIYALGDVTDRVQLTPVAIHEAMCFIETEYKNNPTSP-DHDLIATAVFSQPEIGT 353 Query: 424 VGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLG 483 VG+TE+EA K+ + ++ Y F PM ++ RK K +MK+V + KVVG H+ G Sbjct: 354 VGITEEEAARKF--QEIEVYRAEFRPMKATLSGRKEKTIMKLVVNAADRKVVGAHILGHD 411 Query: 484 CDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTL 521 EM Q ++++ G TK DFD T+A+HPT++EELVT+ Sbjct: 412 AGEMAQLLGISLRAGCTKDDFDRTMAVHPTAAEELVTM 449 >1ONF-A nrPDB Length = 500 Score = 442 bits (1136), Expect = e-124, Method: Composition-based stats. Identities = 199/508 (39%), Positives = 291/508 (57%), Gaps = 64/508 (12%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 YD +VIGGGSGG+A+ARRAA A+ A+VE +LGGTCVNVGCVPKK+M+N A + + Sbjct: 3 YDLIVIGGGSGGMAAARRAARHNAKVALVEKSRLGGTCVNVGCVPKKIMFNAASVHDILE 62 Query: 125 DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTI 184 + YGF + + FN ++ E+RD Y+ RLN IY+ NL+K +++ G A+F S+ + I Sbjct: 63 NSRHYGFDT-KFSFNLPLLVERRDKYIQRLNNIYRQNLSKDKVDLYEGTASFLSENRILI 121 Query: 185 E------------VSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPG 232 + ++ + +ILIA G P P + G I+SD FF ++E Sbjct: 122 KGTKDNNNKDNGPLNEEILEGRNILIAVGNKPVFP---PVKGIENTISSDEFFNIKE-SK 177 Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF 292 + IVG+GYIAVE+ ++ LG + + R +++LR FD + +++ + ++ F Sbjct: 178 KIGIVGSGYIAVELINVIKRLGIDSYIFARGNRILRKFDESVINVLENDMKKNNINIVTF 237 Query: 293 SQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD 352 + V E+KK + L + D +++ +GR P+T++L L KL ++T+ Sbjct: 238 ADVVEIKKVSDK-------NLSIHLSDGRIYEHFDHVIYCVGRSPDTENLKLEKLNVETN 290 Query: 353 DKGHIIVDEFQNTNVKGIYAVGDVC----------------------------------G 378 +I+VDE Q T+V IYAVGD C Sbjct: 291 -NNYIVVDENQRTSVNNIYAVGDCCMVKKSKEIEDLNLLKLYNEERYLNKKENVTEDIFY 349 Query: 379 KALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIE 438 LTPVAI AGR LA RLF K K +Y IPTV+FSHPPIGT+GL+E+ AI YG E Sbjct: 350 NVQLTPVAINAGRLLADRLFLKKT-RKTNYKLIPTVIFSHPPIGTIGLSEEAAIQIYGKE 408 Query: 439 NVKTYSTSFTPMYHAV----TKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVA 494 NVK Y + FT ++ +V + K K +K+VC K+E + G+H+ GL DE++QGFAVA Sbjct: 409 NVKIYESKFTNLFFSVYDIEPELKEKTYLKLVCVGKDELIKGLHIIGLNADEIVQGFAVA 468 Query: 495 VKMGATKADFDNTVAIHPTSSEELVTLR 522 +KM ATK DFD T+ IHPT++EE +TL+ Sbjct: 469 LKMNATKKDFDETIPIHPTAAEEFLTLQ 496 >2EQ6-A nrPDB Length = 464 Score = 437 bits (1124), Expect = e-123, Method: Composition-based stats. Identities = 133/459 (28%), Positives = 222/459 (48%), Gaps = 15/459 (3%) Query: 62 VASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSE 121 + +YD +VIG G GG +A RAA+LG + VE+ ++GG C+NVGC+P K + + A Sbjct: 4 MKTYDLIVIGTGPGGYHAAIRAAQLGLKVLAVEAGEVGGVCLNVGCIPTKALLHAAETLH 63 Query: 122 FMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPK 181 + +G + + + + + RD V +L L + +E++RG A Sbjct: 64 HLKVAEGFGLK-AKPELDLKKLGGWRDQVVKKLTGGVGTLLKGNGVELLRGFARLVGPK- 121 Query: 182 PTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEE-LPGRSVIVGAG 240 +EV G++Y A +++ATG P P S ++EE LP R +++G G Sbjct: 122 -EVEVGGERYGAKSLILATGSEPL--ELKGFPFGEDVWDSTRALKVEEGLPKRLLVIGGG 178 Query: 241 YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK 300 + +E+ + LG++ +L+ ++L D + LE G+ V ++ +K Sbjct: 179 AVGLELGQVYRRLGAEVTLIEYMPEILPQGDPETAALLRRALEKEGIRVRTKTKAVGYEK 238 Query: 301 TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD 360 GL V + A G + + + + GR P T+ L L K G++ D++G I V+ Sbjct: 239 KKDGLHVRLEPAEGGEGEEVVVDKVLVAV----GRKPRTEGLGLEKAGVKVDERGFIRVN 294 Query: 361 EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP 420 T+V G+YA+GD LL A+ G A +DS DY +P+VV++ P Sbjct: 295 ARMETSVPGVYAIGDAARPPLLAHKAMREGLIAAENAAG--KDSAFDYQ-VPSVVYTSPE 351 Query: 421 IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ 480 VGLTE+EA VK A+T + ++K+V + + ++G+ + Sbjct: 352 WAGVGLTEEEAKRAGYK--VKVGKFPLAASGRALTLGGAEGMVKVVGDEETDLLLGVFIV 409 Query: 481 GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELV 519 G E++ A+A++MGAT D TV HPT SE L+ Sbjct: 410 GPQAGELIAEAALALEMGATLTDLALTVHPHPTLSESLM 448 >6AON-A nrPDB Length = 478 Score = 436 bits (1121), Expect = e-122, Method: Composition-based stats. Identities = 119/469 (25%), Positives = 214/469 (45%), Gaps = 23/469 (4%) Query: 63 ASYDYLVIGGGSGGLASARRAAELGARAAVVESHK-------LGGTCVNVGCVPKKVMWN 115 +D +VIG G GG +A RAA+LG A +++ + GGTC NVGC+P K + Sbjct: 6 KQFDVVVIGAGPGGYIAAIRAAQLGMSVACIDAWQNGQGGPAPGGTCTNVGCIPSKALLQ 65 Query: 116 TAVHSEFM-HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHA 174 ++ H E H A++G + +++ V + N K+ + G Sbjct: 66 SSEHYEQANHHFAEHGIEVKGVSLKLDTLIGRKNTVVKQNNDGILYLFKKNKVTYFHGKG 125 Query: 175 AFTS--DPKPTIEVSGKK---YTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEE 229 AF D +I+V+G A H+++ATG ++ +++DG + Sbjct: 126 AFAGQVDGGWSIKVTGTTDADLVAKHVIVATGSSARELPGLPFDEKNI-LSNDGALNIGA 184 Query: 230 LPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEV 289 +P + ++GAG I +EM + LG++ +++ + L + D ++ + G+++ Sbjct: 185 VPKKLGVIGAGVIGLEMGSVWRRLGAEVTILEAMPEFLAAADQQVAKEALKSFAKQGLDI 244 Query: 290 LKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGI 349 ++ E+K + V V A ++ VD L+ +IGRVP T L+ +G+ Sbjct: 245 QTGVKIGEIKAAAKSITVPYVDAKGAEQKLV-----VDKLIVSIGRVPYTGGLNAEAVGL 299 Query: 350 QTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYN 409 + D++G + VDE TN+ ++AVGDV +L A G +A R+ + +++ Sbjct: 300 KLDERGFVAVDEDCKTNLPNVWAVGDVVRGPMLAHKAEEEGVAVAERIAG--QHGHVNFA 357 Query: 410 NIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCAN 469 +P V+++ P I VG TE + + G E K S F A T K++ Sbjct: 358 TVPWVIYTSPEIAWVGKTEQQ-LKAEGRE-YKAGSFPFMANGRARALGDTTGFAKVIADA 415 Query: 470 KEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 K ++V+G+H+ G E++ ++ D HPT SE + Sbjct: 416 KTDEVLGVHIIGPMASELISEAVTIMEFRGAAEDIARICHAHPTLSEAV 464 >6BZ0-A nrPDB Length = 480 Score = 435 bits (1119), Expect = e-122, Method: Composition-based stats. Identities = 119/464 (25%), Positives = 222/464 (47%), Gaps = 21/464 (4%) Query: 63 ASYDYLVIGGGSGGLASARRAAELGARAAVVESH------KLGGTCVNVGCVPKKVMWNT 116 +D +VIGGG GG +A RAA+LG + A +E LGGTC+NVGC+P K + ++ Sbjct: 6 QQFDLVVIGGGPGGYEAAIRAAQLGFKVACIEKRIHNGKPSLGGTCLNVGCIPSKALLDS 65 Query: 117 AVHSE-FMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAA 175 + E +H AD+G + E F+ + ++D V +L L + IE ++G Sbjct: 66 SHRYEDTVHHLADHGITTGEVNFDLAKLLARKDKIVDQLTGGIDQLLKGNGIEWLKGTGK 125 Query: 176 FTSDPKPTI---EVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPG 232 + K E + ++++A+G +P + + + + S G E+P Sbjct: 126 LLAGKKVEFVPHEGETQILEPKYVILASGSVPVNIPVAPVD-QDIIVDSTGALNFPEVPK 184 Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF 292 R ++GAG I +E+ + LG++ + D L D +S + L G+++ Sbjct: 185 RLGVIGAGVIGLELGSVWRRLGAEVVVFEAMDAFLPMADKALSKEYQKILTKQGLDIRIG 244 Query: 293 SQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD 352 ++V + ++G EV++ G T D L+ +GR + L GI+ Sbjct: 245 AKVSGTE--VNGREVTVKYTQAGEDKEQT----FDKLIVCVGRKAYAEGLLAEDSGIKLT 298 Query: 353 DKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIP 412 ++G + V++ T+V+G+YA+GD+ +L A+ G R+ + ++++Y+ I Sbjct: 299 ERGLVEVNDHCATSVEGVYAIGDLVRGPMLAHKAMEEGVMAVERIHGHA--AQVNYDTII 356 Query: 413 TVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEE 472 +++++HP VGLTE++A K VKT F A+ + +K V K + Sbjct: 357 SIIYTHPEAAWVGLTEEQAKEKG--HEVKTGQFGFAVNGRALAAGEGAGFVKFVADAKTD 414 Query: 473 KVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSE 516 +++G+H+ G +++ +A++ ++ D HPT SE Sbjct: 415 RLLGMHVIGPAASDIVHQGMIALEFVSSVEDLQLMTFGHPTFSE 458 >5X1Y-B nrPDB Length = 554 Score = 426 bits (1095), Expect = e-119, Method: Composition-based stats. Identities = 140/456 (30%), Positives = 237/456 (51%), Gaps = 13/456 (2%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFM 123 +YD L+IG G+ +SA +A E GA+ ++E +GGTCVN+GCVP K + Sbjct: 84 NYDLLIIGSGAAAFSSAIKAIEYGAKVGMIERGTVGGTCVNIGCVPSKTLLRAGEIIHLS 143 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSRL-NAIYQNNLTKSHIEIIRGHAAFTSDPKP 182 D+ G + G+ + + ++D VS L N Y + + + + ++I+G A F Sbjct: 144 KDNPFIGLQTSAGEVDLASLITQKDKLVSELRNQKYMDLIDEYNFDLIKGEAKFVD--AS 201 Query: 183 TIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYI 242 T+EV+G K +A LIATG PS P S + +TS +L+++P R ++G+GYI Sbjct: 202 TVEVNGAKLSAKRFLIATGASPSLPQISGLEKMDY-LTSTTLLELKKIPKRLTVIGSGYI 260 Query: 243 AVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTL 302 +E+ + LGS+ +LM R +++L+ +D IS + + L G+ ++K + + V+++ Sbjct: 261 GMELGQLFHHLGSEITLMQRSERLLKEYDPEISESVEKALIEQGINLVKGATFERVEQSG 320 Query: 303 SGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEF 362 V + + + D LL A GR PNT L+L+ G++T I++++F Sbjct: 321 EIKRVYVTVNGSRE------VIESDQLLVATGRKPNTDSLNLSAAGVETGKNNEILINDF 374 Query: 363 QNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIG 422 T+ + IYA GDV VA G + + K+D + +P V F++P + Sbjct: 375 GQTSNEKIYAAGDVTLGPQFVYVAAYEGGIITDNAIG-GLNKKIDLSVVPAVTFTNPTVA 433 Query: 423 TVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGL 482 TVGLTE++A K +VKT + A+ R+T V K+V + KV+G+H+ Sbjct: 434 TVGLTEEQAKEKG--YDVKTSVLPLDAVPRAIVNRETTGVFKLVADAETLKVLGVHIVSE 491 Query: 483 GCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 +++ ++AVK G T D T+A + T +E L Sbjct: 492 NAGDVIYAASLAVKFGLTVEDLTETLAPYLTMAEGL 527 >4JDR-A nrPDB Length = 474 Score = 417 bits (1073), Expect = e-117, Method: Composition-based stats. Identities = 123/455 (27%), Positives = 210/455 (46%), Gaps = 14/455 (3%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVNVGCVPKKVMWNTAVHSEFMHD 125 +V+G G G ++A R A+LG +VE + LGG C+NVGC+P K + + A E Sbjct: 9 VVVLGAGPAGYSAAFRCADLGLETVIVERYNTLGGVCLNVGCIPSKALLHVAKVIEEAKA 68 Query: 126 HADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIE 185 A++G E K + I+ ++ +++L ++++ G FT +E Sbjct: 69 LAEHGIVFGEPKTDIDKIRTWKEKVINQLTGGLAGMAKGRKVKVVNGLGKFTGANTLEVE 128 Query: 186 VSGKK--YTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIA 243 K + +IA G P + S +L+E+P R +++G G I Sbjct: 129 GENGKTVINFDNAIIAAGSRPIQLPFIPHEDPRI-WDSTDALELKEVPERLLVMGGGIIG 187 Query: 244 VEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLS 303 +EM + ALGS+ ++ D+V+ + D I T+ + ++ ++V V+ Sbjct: 188 LEMGTVYHALGSQIDVVEMFDQVIPAADKDIVKVFTKRISK-KFNLMLETKVTAVEAKED 246 Query: 304 GLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQ 363 G+ V+M P D +L AIGRVPN K+L K G++ DD+G I VD+ Sbjct: 247 GIYVTMEGKKAPAEPQR-----YDAVLVAIGRVPNGKNLDAGKAGVEVDDRGFIRVDKQL 301 Query: 364 NTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGT 423 TNV I+A+GD+ G+ +L + G A + K D IP++ ++ P + Sbjct: 302 RTNVPHIFAIGDIVGQPMLAHKGVHEGHVAAEVIAGKKH--YFDPKVIPSIAYTEPEVAW 359 Query: 424 VGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLG 483 VGLTE EA K + +T + + A+ + K++ + +V+G + G Sbjct: 360 VGLTEKEAKEKG--ISYETATFPWAASGRAIASDCADGMTKLIFDKESHRVIGGAIVGTN 417 Query: 484 CDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 E+L +A++MG D T+ HPT E + Sbjct: 418 GGELLGEIGLAIEMGCDAEDIALTIHAHPTLHESV 452 >2QAE-A nrPDB Length = 468 Score = 412 bits (1059), Expect = e-115, Method: Composition-based stats. Identities = 107/450 (23%), Positives = 207/450 (46%), Gaps = 22/450 (4%) Query: 79 SARRAAELGARAAVVES-HKLGGTCVNVGCVPKKVMWNTAVHSEFMH-DHADYGFPSCEG 136 ++ +AA+LG + A VE LGGTC+NVGC+P K + + H + A YG EG Sbjct: 17 ASIKAAQLGMKTACVEKRGALGGTCLNVGCIPSKALLHATHLYHDAHANFARYGLMGGEG 76 Query: 137 -KFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSG-----KK 190 + ++++++ V L + K+ + +G +F + +I V+G + Sbjct: 77 VTMDSAKMQQQKERAVKGLTGGVEYLFKKNKVTYYKGEGSF--ETAHSIRVNGLDGKQEM 134 Query: 191 YTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGIL 250 +IATG P+ + ++S G L +P V++G G I +E+ + Sbjct: 135 LETKKTIIATGSEPTELPFLPFD-EKVVLSSTGALALPRVPKTMVVIGGGVIGLELGSVW 193 Query: 251 SALGSKTSLMIRHDKVLRSFDSMISTNCTEEL-ENAGVEVLKFSQVKEVKKTLSGLEVSM 309 + LG++ +++ + + D ++ L +N ++ + ++V + + Sbjct: 194 ARLGAEVTVVEFAPRCAPTLDEDVTNALVGALAKNEKMKFMTSTKVVGGTNNGDSVSLE- 252 Query: 310 VTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKG 369 V G+ +T + LL ++GR P T L L+K+ + +++G + + + T++ Sbjct: 253 VEGKNGKRETVT----CEALLVSVGRRPFTGGLGLDKINVAKNERGFVKIGDHFETSIPD 308 Query: 370 IYAVGDVCGK-ALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTE 428 +YA+GDV K +L A G A L + ++Y IP V+++ P + +VG +E Sbjct: 309 VYAIGDVVDKGPMLAHKAEDEGVACAEILAG--KPGHVNYGVIPAVIYTMPEVASVGKSE 366 Query: 429 DEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEML 488 DE + K G+ K F A +K++ ++++G+H+ E++ Sbjct: 367 DE-LKKEGV-AYKVGKFPFNANSRAKAVSTEDGFVKVLVDKATDRILGVHIVCTTAGELI 424 Query: 489 QGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 +A++ GA+ D T HPT SE L Sbjct: 425 GEACLAMEYGASSEDVGRTCHAHPTMSEAL 454 >1LVL-A nrPDB Length = 458 Score = 396 bits (1017), Expect = e-110, Method: Composition-based stats. Identities = 118/455 (25%), Positives = 207/455 (45%), Gaps = 21/455 (4%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDH 126 L+IGGG GG +A RA +LG +VE LGGTC+N+GC+P K + + A Sbjct: 8 LLIIGGGPGGYVAAIRAGQLGIPTVLVEGQALGGTCLNIGCIPSKALIHVAEQFHQASRF 67 Query: 127 AD---YGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 + G + + +D V RL L K ++++ G A + Sbjct: 68 TEPSPLGISVASPRLDIGQSVAWKDGIVDRLTTGVAALLKKHGVKVVHGWAKVLDGKQ-- 125 Query: 184 IEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIA 243 +EV G++ H+L+ATG +P I+S + LP V+VG GYI Sbjct: 126 VEVDGQRIQCEHLLLATGSSSV--ELPMLPLGGPVISSTEALAPKALPQHLVVVGGGYIG 183 Query: 244 VEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLS 303 +E+ LG++ S++ +++L ++DS ++ E L+ G+ + V Sbjct: 184 LELGIAYRKLGAQVSVVEARERILPTYDSELTAPVAESLKKLGIALHLGHSV-------E 236 Query: 304 GLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQ 363 G E + A G+ + + D +L A+GR P TK +L L ++ + I +DE Sbjct: 237 GYENGCLLANDGKGGQLR--LEADRVLVAVGRRPRTKGFNLECLDLKMN-GAAIAIDERC 293 Query: 364 NTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGT 423 T++ ++A+GDV G+ +L A+A G +A + + + + I V F+ P + Sbjct: 294 QTSMHNVWAIGDVAGEPMLAHRAMAQGEMVAEIIAG--KARRFEPAAIAAVCFTDPEVVV 351 Query: 424 VGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLG 483 VG T ++A + G++ + F A++ +++V ++G G+ Sbjct: 352 VGKTPEQA-SQQGLDCI-VAQFPFAANGRAMSLESKSGFVRVVARRDNHLILGWQAVGVA 409 Query: 484 CDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 E+ FA +++MGA D T+ HPT E + Sbjct: 410 VSELSTAFAQSLEMGACLEDVAGTIHAHPTLGEAV 444 >6CMZ-A nrPDB Length = 466 Score = 395 bits (1015), Expect = e-110, Method: Composition-based stats. Identities = 127/457 (27%), Positives = 206/457 (45%), Gaps = 20/457 (4%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDH 126 LVIGGG GG +A RA +LG +VE +LGGTC+N+GC+P K + + A E H Sbjct: 11 LLVIGGGPGGYVAAIRAGQLGIPTVLVERDRLGGTCLNIGCIPSKALIHVADAFEQACGH 70 Query: 127 ADY---GFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 A G + + +D V RL L KS + ++ G A Sbjct: 71 AGEGALGIRVRAPEIDIAKSVAWKDGIVDRLTRGVGALLKKSGVRVLHGEARVIDGKTVE 130 Query: 184 IEVSGK--KYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGY 241 + +G + H+L+ATG P G ++S LP R V+VGAGY Sbjct: 131 VVSAGHAVRIGCEHLLLATGSEPVELPSMPFGG--HVVSSTDALSPATLPKRLVVVGAGY 188 Query: 242 IAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKT 301 I +E+ + LG S++ ++VL ++D+ + + L GV + +V + K Sbjct: 189 IGLELGIVYRKLGVDVSVVEAAERVLPAYDAELVRPVADSLARLGVRLWLGHKVLGLDKH 248 Query: 302 LSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDE 361 + V LP D +L A+GR P L L + + + + +D+ Sbjct: 249 -GAVRVQAADGAEQTLP-------ADRVLVAVGRRPRVDGFGLETLMLDRNGR-ALRIDD 299 Query: 362 FQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPI 421 T+++ ++A+GDV G+ +L A+A G +A + + + IP V F+ P I Sbjct: 300 TCRTSMRNVWAIGDVAGEPMLAHRAMAQGEMVAELIAGRR--RQFMPAAIPAVCFTDPEI 357 Query: 422 GTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQG 481 T G + D+A H G++ + + S F A+T + T +++V +VG G Sbjct: 358 VTAGWSPDDA-HAAGVDCL-SASFPFAANGRAMTLQATDGFVRVVARRDNHLIVGWQAVG 415 Query: 482 LGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 G E+ F+ +++MGA D T+ HPT E L Sbjct: 416 RGVSELAAAFSQSLEMGARLEDIGGTIHAHPTLGEAL 452 >3II4-A nrPDB Length = 466 Score = 386 bits (991), Expect = e-107, Method: Composition-based stats. Identities = 128/466 (27%), Positives = 210/466 (45%), Gaps = 21/466 (4%) Query: 60 GAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVH 119 G++ YD +V+G G GG +A RAA+LG A+VE GG C+NVGC+P K + A Sbjct: 1 GSMTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPKYWGGVCLNVGCIPSKALLRNAEL 60 Query: 120 SEFM-HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTS 178 D +G S E F++ + ++ A + K+ I I G+ F Sbjct: 61 VHIFTKDAKAFGI-SGEVTFDYGIAYDRSRKVAEGRVAGVHFLMKKNKITEIHGYGTFAD 119 Query: 179 DPKPTIEVSG---KKYTAPHILIATGGMPSTPHESQIPGASLG---ITSDGFFQLEELPG 232 ++++ + T + +IATG +PG SL +T + ELP Sbjct: 120 ANTLLVDLNDGGTESVTFDNAIIATGSSTRL-----VPGTSLSANVVTYEEQILSRELPK 174 Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF 292 +I GAG I +E +L G +++ + L + D+ +S ++ + GV +L Sbjct: 175 SIIIAGAGAIGMEFGYVLKNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILTA 234 Query: 293 SQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD 352 ++V+ + G +V++ G + + +L AIG PN + L+K G+ Sbjct: 235 TKVESI--ADGGSQVTVTVTKDG----VAQELKAEKVLQAIGFAPNVEGYGLDKAGVALT 288 Query: 353 DKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIP 412 D+ I VD++ TNV IYA+GDV G L VA A G A + + + D+ +P Sbjct: 289 DRKAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLGDHRMLP 348 Query: 413 TVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEE 472 F P + + GLTE +A ++ +V FT A +K+V K Sbjct: 349 RATFCQPNVASFGLTEQQARNEG--YDVVVAKFPFTANAKAHGVGDPSGFVKLVADAKHG 406 Query: 473 KVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 +++G H+ G E+L +A + T ++ V HPT SE L Sbjct: 407 ELLGGHLVGHDVAELLPELTLAQRWDLTASELARNVHTHPTMSEAL 452 >4YWO-A nrPDB Length = 462 Score = 362 bits (929), Expect = e-100, Method: Composition-based stats. Identities = 127/459 (27%), Positives = 207/459 (45%), Gaps = 27/459 (5%) Query: 61 AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS 120 + +IG G+ G A+ +A ELG + ++ ++GGTCVNVGCVP K M A Sbjct: 12 QDPMHKLAIIGYGAAGFAAMIKANELGVKPVLIGKGEIGGTCVNVGCVPSKRMLYIAEIY 71 Query: 121 EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNA-IYQNNLTKSHIEIIRGHAAFTSD 179 + + E + +E +D V + Y++ L+ +E+I+G A F S Sbjct: 72 KKAREVTG-----SEVYPPFSSFQE-KDGLVQEMRKTKYEDLLSYYDVELIQGEARFISP 125 Query: 180 PKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGA 239 ++V+G+ A +IATG P P + T+ + ++G Sbjct: 126 HA--VKVNGQVIEAEKFVIATGSSPLIPRIPGLDKVGF-WTNREALSPDRRIDSLAVIGG 182 Query: 240 GYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVK 299 +A+E A + S + + +++ R ++ ++ S +EN GV V+ VKEV+ Sbjct: 183 RALALEFAQMYSRMKVEVAILQRSPVLIPDWEPEASVEARRIMENDGVAVVTGVNVKEVR 242 Query: 300 KTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIV 359 K + ++ V + D +L A GR PN L L G++ +++G I V Sbjct: 243 KGAGKIVITDKGEV-----------EADEILLATGRKPNVD-LGLENAGVRLNERGGIKV 290 Query: 360 DEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHP 419 D+ T+ IYA GDV G +L +A G ++D N +P V+F+ P Sbjct: 291 DDELRTDNPHIYAAGDVLGGKMLEALAGRQGSIATENAL-TGSHKRVDENAVPQVIFTQP 349 Query: 420 PIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHM 479 + VGLTE EA K G + S + R +KMV N ++VG+H Sbjct: 350 NLARVGLTEAEARAKEGEVEARVLPMSSVAKAEIINSRL--GFVKMVTMN--GRIVGVHA 405 Query: 480 QGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 G EM+ A+A++ GAT D +TV + PT +E L Sbjct: 406 VGENVAEMIGEAALAIRFGATVHDLIDTVHMFPTIAESL 444 >1OJT-A nrPDB Length = 482 Score = 351 bits (901), Expect = 4e-97, Method: Composition-based stats. Identities = 129/476 (27%), Positives = 215/476 (45%), Gaps = 33/476 (6%) Query: 61 AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKKVMWNTAVH 119 A A YD +V+GGG GG ++A AA+ G + A+VE +K LGG C+NVGC+P K + + A Sbjct: 3 ADAEYDVVVLGGGPGGYSAAFAAADEGLKVAIVERYKTLGGVCLNVGCIPSKALLHNAAV 62 Query: 120 SEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSD 179 + + A G E + + +++ +D VSRL +++I+G F Sbjct: 63 IDEVRHLAANGIKYPEPELDIDMLRAYKDGVVSRLTGGLAGMAKSRKVDVIQGDGQFLDP 122 Query: 180 PKPTI-------------EVSGKKYTAPHILIATGGM----PSTPHESQIPGASLGITSD 222 + K + +IA G P P + +I I S Sbjct: 123 HHLEVSLTAGDAYEQAAPTGEKKIVAFKNCIIAAGSRVTKLPFIPEDPRI------IDSS 176 Query: 223 GFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEEL 282 G L+E+PG+ +I+G G I +EM + S LGS+ ++ D +++ D + ++ Sbjct: 177 GALALKEVPGKLLIIGGGIIGLEMGTVYSTLGSRLDVVEMMDGLMQGADRDLVKVWQKQN 236 Query: 283 ENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDL 342 E ++ ++ V+ G+ V+ A + P D +L A GR PN K + Sbjct: 237 EYRFDNIMVNTKTVAVEPKEDGVYVTFEGANAPKEPQR-----YDAVLVAAGRAPNGKLI 291 Query: 343 SLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKE 402 S K G+ D+G I VD+ TNV IYA+GD+ G+ +L A+ G A +K Sbjct: 292 SAEKAGVAVTDRGFIEVDKQMRTNVPHIYAIGDIVGQPMLAHKAVHEGHVAAENCAGHK- 350 Query: 403 DSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCV 462 + D IP V ++ P + VG TE A K + + + A+ K Sbjct: 351 -AYFDARVIPGVAYTSPEVAWVGETELSA--KASARKITKANFPWAASGRAIANGCDKPF 407 Query: 463 MKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 K++ + +++G + G +M+ +A++MG AD T+ HPT E + Sbjct: 408 TKLIFDAETGRIIGGGIVGPNGGDMIGEVCLAIEMGCDAADIGKTIHPHPTLGESI 463 >5U25-A nrPDB Length = 602 Score = 348 bits (892), Expect = 4e-96, Method: Composition-based stats. Identities = 128/479 (26%), Positives = 214/479 (44%), Gaps = 33/479 (6%) Query: 58 AAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKKVMWNT 116 A A YD +V+GGG GG ++A AA+ G + A+VE +K LGG C+NVGC+P K + + Sbjct: 119 GGAADAEYDVVVLGGGPGGYSAAFAAADEGLKVAIVERYKTLGGVCLNVGCIPSKALLHN 178 Query: 117 AVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAF 176 A + + A G E + + +++ +D VSRL +++I+G F Sbjct: 179 AAVIDEVRHLAANGIKYPEPELDIDMLRAYKDGVVSRLTGGLAGMAKSRKVDVIQGDGQF 238 Query: 177 TSDPKPTI-------------EVSGKKYTAPHILIATGGM----PSTPHESQIPGASLGI 219 + K + +IA G P P + +I I Sbjct: 239 LDPHHLEVSLTAGDAYEQAAPTGEKKIVAFKNCIIAAGSRVTKLPFIPEDPRI------I 292 Query: 220 TSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCT 279 S G L+E+PG+ +I+G G I +EM + S LGS+ ++ D +++ D + Sbjct: 293 DSSGALALKEVPGKLLIIGGGIIGLEMGTVYSTLGSRLDVVEMMDGLMQGADRDLVKVWQ 352 Query: 280 EELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNT 339 ++ E ++ ++ V+ G+ V+ A + P D +L A GR PN Sbjct: 353 KQNEYRFDNIMVNTKTVAVEPKEDGVYVTFEGANAPKEPQR-----YDAVLVAAGRAPNG 407 Query: 340 KDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFE 399 K +S K G+ D+G I VD+ TNV IYA+GD+ G+ +L A+ G A Sbjct: 408 KLISAEKAGVAVTDRGFIEVDKQMRTNVPHIYAIGDIVGQPMLAHKAVHEGHVAAENCAG 467 Query: 400 YKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKT 459 +K + D IP V ++ P + VG TE A K + + + A+ Sbjct: 468 HK--AYFDARVIPGVAYTSPEVAWVGETELSA--KASGRKITKANFPWAASGRAIANGCD 523 Query: 460 KCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 K++ + +++G + G +M+ +A++MG AD T+ HPT E + Sbjct: 524 NGFTKLIFDAETGRIIGGGIVGPNGGDMIGEVCLAIEMGCDAADIGKTIHPHPTLGESI 582 >1ZK7-A nrPDB Length = 467 Score = 342 bits (877), Expect = 2e-94, Method: Composition-based stats. Identities = 123/458 (26%), Positives = 206/458 (44%), Gaps = 22/458 (4%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDH 126 VIG G +A+A +A E GA+ ++E +GGTCVNVGCVP K+M A + + Sbjct: 7 VAVIGSGGAAMAAALKAVEQGAQVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRES 66 Query: 127 A-DYGFPSCEGKFNWRVIKEKRDAYVSRL-NAIYQNNLTKS-HIEIIRGHAAFTSDPKPT 183 D G + + + ++ A V L +A Y+ L + I ++ G A F D T Sbjct: 67 PFDGGIAATVPTIDRSKLLAQQQARVDELRHAKYEGILGGNPAITVVHGEARFKDDQSLT 126 Query: 184 IEVSG---KKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG 240 + ++ + L+ATG P+ P + S TS + +P R ++G+ Sbjct: 127 VRLNEGGERVVMFDRCLVATGASPAVPPIPGLK-ESPYWTSTEALASDTIPERLAVIGSS 185 Query: 241 YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK 300 +A+E+A + LGSK +++ R+ R D I T G+EVL+ +Q +V Sbjct: 186 VVALELAQAFARLGSKVTVLARNTLFFRE-DPAIGEAVTAAFRAEGIEVLEHTQASQVAH 244 Query: 301 TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD 360 ++ D LL A GR PNT+ L+L+ G+ + +G I++D Sbjct: 245 MDGEFVLTTTHGE----------LRADKLLVATGRTPNTRSLALDAAGVTVNAQGAIVID 294 Query: 361 EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP 420 + T+ IYA GD + VA A + D+ LD +P VVF+ P Sbjct: 295 QGMRTSNPNIYAAGDCTDQPQFVYVAAA--AGTRAAINMTGGDAALDLTAMPAVVFTDPQ 352 Query: 421 IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ 480 + TVG +E EA H + +T + P A+ T+ +K+V +++G+ Sbjct: 353 VATVGYSEAEAHHDGIETDSRTLTLDNVP--RALANFDTRGFIKLVIEEGSHRLIGVQAV 410 Query: 481 GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 E++Q A+A++ T + + + + T E L Sbjct: 411 APEAGELIQTAALAIRNRMTVQELADQLFPYLTMVEGL 448 >3IC9-A nrPDB Length = 492 Score = 311 bits (797), Expect = 5e-85, Method: Composition-based stats. Identities = 102/464 (21%), Positives = 170/464 (36%), Gaps = 13/464 (2%) Query: 62 VASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSE 121 V + D +IG G+ G+ + R A + + ++E G TC VGC+P K++ A S Sbjct: 6 VINVDVAIIGTGTAGMGAYRAAKKHTDKVVLIEGGAYGTTCARVGCMPSKLLIAAADASY 65 Query: 122 FMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRL-NAIYQNNLTKSHIEIIRGHAAFTSDP 180 +G N + + ++ R + ++ + + IRG A F + Sbjct: 66 HASQTDLFGIQVDRISVNGKAVMKRIQTERDRFVGFVVESVESFDEQDKIRGFAKFLDEH 125 Query: 181 KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG 240 ++ + A I+IATG P+ P G+ L +T+D F+L +LP + G G Sbjct: 126 TLQVDDHSQVI-AKRIVIATGSRPNYPEFLAAAGSRL-LTNDNLFELNDLPKSVAVFGPG 183 Query: 241 YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK 300 I +E+ LS LG + R V D + + ++V + Sbjct: 184 VIGLELGQALSRLGVIVKVFGRSGSVANLQDEEMKRYAEKTFNEE-FYFDAKARVISTIE 242 Query: 301 TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD 360 +EV + +L A GR N L L I+ D K + D Sbjct: 243 KEDAVEVIYFDKSGQKTTES-----FQYVLAATGRKANVDKLGLENTSIELDKKNSPLFD 297 Query: 361 E-FQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHP 419 E T+V I+ GD L A G+ Y ++ +VVF+ P Sbjct: 298 ELTLQTSVDHIFVAGDANNTLTLLHEAADDGKVAGTNAGAYPVIAQGQRRAPLSVVFTEP 357 Query: 420 PIGTVGLTEDEAIHKYGIE---NVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVG 476 + +VGL+ + Y + N SF + K K ++ + + +G Sbjct: 358 QVASVGLSLRQIEDLYADQDAANYVVGQVSFEGQGRSRVMGKNKGLLNVYADRTSGEFLG 417 Query: 477 IHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVT 520 M G + + A A + T HP E L T Sbjct: 418 AEMFGPAAEHIGHLLAWARQQQMTVQAMLTMPFYHPVIEEGLRT 461 >3Q6J-A nrPDB Length = 523 Score = 294 bits (754), Expect = 4e-80, Method: Composition-based stats. Identities = 125/491 (25%), Positives = 205/491 (41%), Gaps = 43/491 (8%) Query: 60 GAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKKVMWNTAV 118 YD + IGGG+ G + +G R +V+ LGG+C + CVP + + A Sbjct: 39 NDPREYDAIFIGGGAAGRFGSAYLRAMGGRQLIVDRWPFLGGSCPHNACVPHHLFSDCAA 98 Query: 119 HSEFMHDHAD-YGFPSCEGKFNWRVIKEKRDAYVSRLNA--IYQNNLTKS--HIEIIRGH 173 + Y FP K IKE D + + N N +K ++E I Sbjct: 99 ELMLARTFSGQYWFPDMTEKVVG--IKEVVDLFRAGRNGPHGIMNFQSKEQLNLEYILNC 156 Query: 174 AAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEEL--- 230 A D T+E +GK + A ++++A G P T +PG + D +EEL Sbjct: 157 PAKVIDN-HTVEAAGKVFKAKNLILAVGAGPGT---LDVPGVNAKGVFDHATLVEELDYE 212 Query: 231 PGR-SVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEV 289 PG V+VG AVE +A G +T +++R + + D+ + ++ G+E+ Sbjct: 213 PGSTVVVVGGSKTAVEYGCFFNATGRRTVMLVRTEPLKLIKDNETRAYVLDRMKEQGMEI 272 Query: 290 LKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGI 349 + S V +++ +G V AV P M + D + +G P + +L LG+ Sbjct: 273 ISGSNVTRIEEDANG----RVQAVVAMTPNGEMRIETDFVFLGLGEQPRSAEL-AKILGL 327 Query: 350 QTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYN 409 KG ++V+E+ T+V +YAVGD+ G + + RK K+ Y Sbjct: 328 DLGPKGEVLVNEYLQTSVPNVYAVGDLIGGPM----EMFKARKSGCYAARNVMGEKISYT 383 Query: 410 --NIPTVVFSHPPIGTVGLTEDEAIHK-YGIENVK-----------TYSTSFTPMYHAVT 455 N P + +H + +G+ E+EA + I +K S M +A Sbjct: 384 PKNYPDFLHTHYEVSFLGMGEEEARAAGHEIVTIKMPPDTENGLNVALPASDRTMLYAFG 443 Query: 456 KRKTK--CVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNT--VAIH 511 K K+V K KV+G H G G + Q V +K G T + + + ++ Sbjct: 444 KGTAHMSGFQKIVIDAKTRKVLGAHHVGYGAKDAFQYLNVLIKQGLTVDELGDMDELFLN 503 Query: 512 PTSSEELVTLR 522 PT +L LR Sbjct: 504 PTHFIQLSRLR 514 >1XDI-A nrPDB Length = 499 Score = 293 bits (750), Expect = 1e-79, Method: Composition-based stats. Identities = 104/467 (22%), Positives = 176/467 (37%), Gaps = 27/467 (5%) Query: 67 YLVIGGGSGGLASARRAAEL---GARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFM 123 +++GGG G +A AA + V++ +GG V CVP K + + Sbjct: 5 IVILGGGPAGYEAALVAATSHPETTQVTVIDCDGIGGAAVLDDCVPSKTFIASTGLRTEL 64 Query: 124 HDHA--DYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSD-- 179 + + K + I + + +A L +++I G Sbjct: 65 RRAPHLGFHIDFDDAKISLPQIHARVKTLAAAQSADITAQLLSMGVQVIAGRGELIDSTP 124 Query: 180 -------PKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPG 232 + S ++ A +L+ATG P +Q G + +T + L+ LP Sbjct: 125 GLARHRIKATAADGSTSEHEADVVLVATGASPRILPSAQPDGERI-LTWRQLYDLDALPD 183 Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF 292 ++VG+G E + LG +++ D VL D+ + E GV + K Sbjct: 184 HLIVVGSGVTGAEFVDAYTELGVPVTVVASQDHVLPYEDADAALVLEESFAERGVRLFKN 243 Query: 293 SQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD 352 ++ V +T +G+ V+M + L IG VPNT L L ++GIQ Sbjct: 244 ARAASVTRTGAGVLVTMTDGRT---------VEGSHALMTIGSVPNTSGLGLERVGIQLG 294 Query: 353 DKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIP 412 ++ VD T GIYA GD G L VA GR + S + + Sbjct: 295 RGNYLTVDRVSRTLATGIYAAGDCTGLLPLASVAAMQGRIAMYHALGEGV-SPIRLRTVA 353 Query: 413 TVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEE 472 VF+ P I VG+ +++ G +T A +K+ C Sbjct: 354 ATVFTRPEIAAVGV--PQSVIDAGSVAARTIMLPLRTNARAKMSEMRHGFVKIFCRRSTG 411 Query: 473 KVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELV 519 V+G + E++ AVAV+ T + T+A++P+ S + Sbjct: 412 VVIGGVVVAPIASELILPIAVAVQNRITVNELAQTLAVYPSLSGSIT 458 >3L8K-A nrPDB Length = 466 Score = 290 bits (743), Expect = 8e-79, Method: Composition-based stats. Identities = 108/467 (23%), Positives = 199/467 (42%), Gaps = 32/467 (6%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVE-SHKLGGTCVNVGCVPKKVMWNTAVHSEFM 123 YD +VIG G G A R A+ + + +LGG C+ GCVP K + + + Sbjct: 5 YDVVVIGAGGAGYHGAFRLAKAKYNVLMADPKGELGGNCLYSGCVPSKTVREVIQTAWRL 64 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAI--YQNNLTKSHIEIIRGHAAFTSDPK 181 + A+ P ++ +++++D YV L +N + +G+ Sbjct: 65 TNIANVKIP-----LDFSTVQDRKD-YVQELRFKQHKRNMSQYETLTFYKGYVKIKDPTH 118 Query: 182 PTIEVS-GKKYTAP--HILIATGGMPSTPHESQIPGASLGITSDGFF----QLEELPGRS 234 ++ GK+ A +++IA+G + + ++PG +TSD F +LP Sbjct: 119 VIVKTDEGKEIEAETRYMIIASGAETA---KLRLPGVEYCLTSDDIFGYKTSFRKLPQDM 175 Query: 235 VIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSF-DSMISTNCTEELENAGVEVLKFS 293 VI+GAGYI +E+A I +G +T ++ D+ L + D I L + + S Sbjct: 176 VIIGAGYIGLEIASIFRLMGVQTHIIEMLDRALITLEDQDIVNTLLSIL---KLNIKFNS 232 Query: 294 QVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDD 353 V EVKK + + G + + ++ A GR P + ++G+ Sbjct: 233 PVTEVKKIKDDEYEVIYSTKDGSKKSI----FTNSVVLAAGRRPVIPE-GAREIGLSISK 287 Query: 354 KGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKED-SKLDYNNIP 412 G I+VDE TN+ ++A GD G A A+ A+ + +D +IP Sbjct: 288 TG-IVVDETMKTNIPNVFATGDANGLAPYYHAAVRMSIAAANNIMANGMPVDYVDVKSIP 346 Query: 413 TVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEE 472 +++ P + VG+ +A K GIE V+ + + +K + V+K++ Sbjct: 347 VTIYTIPSLSYVGILPSKA-RKMGIEIVEAEYNMEEDVSAQIYGQK-EGVLKLIFERGSM 404 Query: 473 KVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELV 519 +++G M G+ ++ +AV G + HP+++E + Sbjct: 405 RLIGAWMIGVHSQYLINELGLAVAYGLNAKQLASFAEQHPSTNEIIS 451 >5UWY-A nrPDB Length = 308 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 80/353 (22%), Positives = 126/353 (35%), Gaps = 58/353 (16%) Query: 61 AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS 120 + A YD L+IG G G+ +A AA A++E GG N Sbjct: 1 SNAMYDTLIIGSGPAGMTAALYAARSNLSVAIIEQGAPGGQMNN---------------- 44 Query: 121 EFMHDHADY-GFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSD 179 D +Y G+ G L L K ++E I G + Sbjct: 45 --TFDIENYPGYDHISGP---------------ELAMKMYEPLEKFNVENIYGIVQKIEN 87 Query: 180 --PKPTIEVSGKKYTAPHILIATGGM---PSTPHESQI--PGASLGITSDGFFQLEELPG 232 + Y A ++IATG P E G S DG F ++ Sbjct: 88 FGDYKCVLTEDASYEAKTVIIATGAKYRVLGVPGEEYYTSRGVSYCAVCDGAFFRDQ--- 144 Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF 292 ++VG G AVE A L+ K +++ R D++ N V+ + Sbjct: 145 DLLVVGGGDSAVEEAIYLTQFAKKVTVVHRRDQL-----RAQKILQDRAFANDKVDFIWD 199 Query: 293 SQVKEVKKTLSGL-EVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQT 351 S VKE++ + V + G++ + +G P T + ++ T Sbjct: 200 SVVKEIQGNDIKVSNVLIENVKTGQVTDHA----FGGVFIYVGMNPVTGMVKDLEI---T 252 Query: 352 DDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTP-VAIAAGRKLAHRLFEYKED 403 D +G II D+ T++ GI+A+GDV K L A+ G ++ Y E Sbjct: 253 DSEGWIITDDHMRTSIPGIFAIGDVRQKDLRQITTAVGDGAIAGQGVYHYLES 305 >4GCM-A nrPDB Length = 312 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 80/351 (22%), Positives = 126/351 (35%), Gaps = 58/351 (16%) Query: 63 ASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVN---VGCVPKKVMWNTAVH 119 +D +IG G G+ +A A+ + ++E GG N V P M Sbjct: 5 IDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDL 64 Query: 120 SEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSD 179 S M +HA + A+YQ I+ + + Sbjct: 65 STKMFEHA------------------------KKFGAVYQYG----DIKSVEDKGEY--- 93 Query: 180 PKPTIEVSGKKYTAPHILIATGG---MPSTPHESQI--PGASLGITSDGFFQLEELPGRS 234 I K+ TA ++IATG P E ++ G S DG F R Sbjct: 94 --KVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKN---KRL 148 Query: 235 VIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQ 294 ++G G AVE L+ K +++ R D++ +N ++ + Sbjct: 149 FVIGGGDSAVEEGTFLTKFADKVTIVHRRDEL-----RAQRILQDRAFKNDKIDFIWSHT 203 Query: 295 VKEVKKTLSGL-EVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDD 353 +K + + + V++ + G + D + IG P T LGI T+D Sbjct: 204 LKSINEKDGKVGSVTLTSTKDGSEET----HEADGVFIYIGMKPLTAPFK--DLGI-TND 256 Query: 354 KGHIIVDEFQNTNVKGIYAVGDVCGKALLTPV-AIAAGRKLAHRLFEYKED 403 G+I+ + T+V GI+A GDV K L V A G A EY E Sbjct: 257 VGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEH 307 >4ZN0-A nrPDB Length = 311 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 79/353 (22%), Positives = 128/353 (36%), Gaps = 51/353 (14%) Query: 58 AAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTA 117 + + YD ++IGGG GL + A G ++E +++ G V Sbjct: 1 GSHMASMYDLIIIGGGPAGLTAGIYAVRYGLDTLILERNEISGQISMADIVENYP----- 55 Query: 118 VHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFT 177 GFPS G + R Q K+ I + + + Sbjct: 56 ------------GFPSISGL-----------ELMERFRTHAQEVGVKTTITEV--LSVRS 90 Query: 178 SDPKPTIEVSGKKYTAPHILIATGGMP---STPHESQI--PGASLGITSDGFFQLEELPG 232 K I A ++IATG P P E ++ G S DG F ++ Sbjct: 91 EGTKKIITTDSGDLEAKAVIIATGANPKHLGVPGEKELISKGVSYCAICDGPFFRNKI-- 148 Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELE-NAGVEVLK 291 +VG G AV A LS + K L+ R D + + + ++ +E++ Sbjct: 149 -VAVVGGGNSAVTDALFLSKVAQKVYLVHRRDHL------KAARVLQDRVDGTPNIELIL 201 Query: 292 FSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQT 351 S V E+ T G++ + T + + +G PNT+ + ++ Sbjct: 202 NSHVLEIVGTREGIKKVEKIILEDVNSRETRELSTNGVFIYVGIHPNTEF-----VDVEK 256 Query: 352 DDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPV-AIAAGRKLAHRLFEYKED 403 D+ G I D + T+ KGIYA GD + V A+ G A +EY E Sbjct: 257 DEGGFIKTDRWMETSEKGIYAAGDCRDTPIWQLVTAVRDGAIAATAAYEYIEK 309 >5MJK-A nrPDB Length = 327 Score = 203 bits (517), Expect = 2e-52, Method: Composition-based stats. Identities = 77/356 (21%), Positives = 124/356 (34%), Gaps = 56/356 (15%) Query: 55 PPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMW 114 P + YD ++IG G G+ +A A + ++E GG N + Sbjct: 15 PRGSHMTEKKYDVVIIGSGPAGMTAAMYTARSEMKTLLLERGVPGGQMNNTAEIENYP-- 72 Query: 115 NTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHA 174 G+ + G + E L +E G Sbjct: 73 ---------------GYETIMGPELSMKMAE---------------PLEGLGVENAYGFV 102 Query: 175 AFTSDP--KPTIEVSGKKYTAPHILIATGGMPS---TPHESQI--PGASLGITSDGFFQL 227 D I ++ I+IATG P E + G S DG F Sbjct: 103 TGIEDHGDYKKIITEDDEFITKSIIIATGANHRKLEIPGEEEYGARGVSYCAVCDGAFFR 162 Query: 228 EELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGV 287 + +++G G AVE A L+ G ++M R DK LR+ + + + + Sbjct: 163 NQ---EILVIGGGDSAVEEALYLTRFGQSVTIMHRRDK-LRAQEII----QQRAFKEEKI 214 Query: 288 EVLKFSQVKEVKKTLSGLE-VSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNK 346 + S E+K ++ V G + + +G P + +S Sbjct: 215 NFIWDSVPMEIKGDDKKIQSVVYKNVKTGEVTEKA----FGGIFIYVGLDPVAEFVS--D 268 Query: 347 LGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTP-VAIAAGRKLAHRLFEYK 401 LGI TD+ G II D+ TN+ GI+AVGDV K A+ G + A +++ Sbjct: 269 LGI-TDEAGWIITDDHMRTNIPGIFAVGDVRQKDFRQITTAVGDGAQAAQEAYKFV 323 >2Q7V-A nrPDB Length = 325 Score = 203 bits (517), Expect = 2e-52, Method: Composition-based stats. Identities = 70/337 (20%), Positives = 124/337 (36%), Gaps = 46/337 (13%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFM 123 YD ++IGGG GL +A ++E GG + W+ V + Sbjct: 8 DYDVVIIGGGPAGLTAAIYTGRAQLSTLILEKGMPGGQ----------IAWSEEVEN--- 54 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 FP + ++ + A + ++ ++ H A + T Sbjct: 55 -------FPGFPEPIAGMELAQRMHQQAEKFGAKVE----MDEVQGVQ-HDATSHPYPFT 102 Query: 184 IEVSGKKYTAPHILIATGGMP---STPHESQI--PGASLGITSDGFFQLEELPGRSVIVG 238 + +Y A +++ATG P P E G S T DGFF + V++G Sbjct: 103 VRGYNGEYRAKAVILATGADPRKLGIPGEDNFWGKGVSTCATCDGFFYKG---KKVVVIG 159 Query: 239 AGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEV 298 G AVE L+ + +++ R D + N ++ + + V+E+ Sbjct: 160 GGDAAVEEGMFLTKFADEVTVIHRRDTL-----RANKVAQARAFANPKMKFIWDTAVEEI 214 Query: 299 KKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHII 358 + S V + G + + D + IG VPNT + K + D G++ Sbjct: 215 QGADSVSGVKLRNLKTGEVSELA----TDGVFIFIGHVPNTAFV---KDTVSLRDDGYVD 267 Query: 359 VDEFQNTNVKGIYAVGDVCGKALLTP-VAIAAGRKLA 394 V + TN+ ++A GDV ++ AG + A Sbjct: 268 VRDEIYTNIPMLFAAGDVSDYIYRQLATSVGAGTRAA 304 >3CGD-A nrPDB Length = 480 Score = 199 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 105/463 (22%), Positives = 174/463 (37%), Gaps = 58/463 (12%) Query: 63 ASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEF 122 S +Y++IGG + G+++A + A VV K G C V+ +E Sbjct: 35 GSMNYVIIGGDAAGMSAAMQIVRNDENANVVTLEK-GEIYSYAQCGLPYVISGAIASTE- 92 Query: 123 MHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKP 182 K R +K RD Y ++A ++ +TK E +A T Sbjct: 93 --------------KLIARNVKTFRDKY--GIDAKVRHEVTKVDTEKKIVYAEHTKTKDV 136 Query: 183 TIEVSGKKYTAPHILIATGGMPSTPHES--QIPGASLGIT-SDGFFQLEELP----GRSV 235 +++ +LIATG P P + G L T D L+ L Sbjct: 137 F------EFSYDRLLIATGVRPVMPEWEGRDLQGVHLLKTIPDAERILKTLETNKVEDVT 190 Query: 236 IVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQV 295 I+G G I +EMA LG K ++ R+D + +D ++ +E + +E+L V Sbjct: 191 IIGGGAIGLEMAETFVELGKKVRMIERNDHIGTIYDGDMAEYIYKEADKHHIEILTNENV 250 Query: 296 KEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKG 355 K K V V G D +L ++G PNT L I+T+ KG Sbjct: 251 KAFKGNE---RVEAVETDKGTYK-------ADLVLVSVGVKPNTDFL--EGTNIRTNHKG 298 Query: 356 HIIVDEFQNTNVKGIYAVGDVC----------GKALLTPVAIAAGRKLAHRLFEYKEDSK 405 I V+ + TNV+ +YA GD + A GR + + + K Sbjct: 299 AIEVNAYMQTNVQDVYAAGDCATHYHVIKEIHDHIPIGTTANKQGRLAGLNMLDKRRAFK 358 Query: 406 LDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKM 465 + F + + GL E EA + KT T M K +K+ Sbjct: 359 GTLGT-GIIKFMNLTLARTGLNEKEAKGLH--IPYKTVKVDSTNMAGYYPNAK-PLYLKL 414 Query: 466 VCANKEEKVVGIHMQG-LGCDEMLQGFAVAVKMGATKADFDNT 507 + + ++++G + G G D+ + A+A+ + D ++ Sbjct: 415 LYRSDTKQLLGGQVIGEEGVDKRIDVIAMALFNKMSIHDLEDV 457 >6BWT-A nrPDB Length = 319 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 68/347 (19%), Positives = 119/347 (34%), Gaps = 52/347 (14%) Query: 59 AGAVASY-DYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTA 117 + A+A++ +++G G G +A AA + ++ + GG Sbjct: 1 SNAMANHHKLIILGSGPAGYTAAIYAARANLKPVIITGMQPGGQ---------------- 44 Query: 118 VHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFT 177 Y +P + EK R + I +A Sbjct: 45 ----LTTTTDVYNWPGEPDGIMGPELMEKLQKQAERF---------DTQIVYDTINAVDL 91 Query: 178 SDPKPTIEVSGKKYTAPHILIATGGMPST-----PHESQIPGASLGITSDGFFQLEELPG 232 + + ++YT ++IATG + G S T DGFF Sbjct: 92 QNKPFKLVGEVEQYTCDTLIIATGATAKYLGLESEEKFMGKGVSACATCDGFFYKN---K 148 Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF 292 +VG G AVE A LS + +L+ R D + + ++ E+ ++ + ++ Sbjct: 149 DVAVVGGGNTAVEEALFLSNIAKSVTLIHRRDTL--RSEKILIDKLMEKAQHGNINIIWN 206 Query: 293 SQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD 352 + ++EV G+ + + V + AIG PNT G Sbjct: 207 TTLEEVLGDDMGVNALRIKNIKTNEESQ---MGVAGVFIAIGHTPNTSIF----AGQLEM 259 Query: 353 DKGHIIVD-----EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLA 394 + G+I V + TN+KG++A GDV V A +A Sbjct: 260 ENGYIKVKSGLAGDATQTNIKGVFAAGDVADHVYKQAVTSAGTGCMA 306 >5UTH-A nrPDB Length = 319 Score = 192 bits (488), Expect = 3e-49, Method: Composition-based stats. Identities = 70/343 (20%), Positives = 129/343 (37%), Gaps = 51/343 (14%) Query: 59 AGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAV 118 + + +D ++IG G G +A AA + V E + GG +M T V Sbjct: 10 STSQTVHDVIIIGSGPAGYTAAIYAARAQLKPLVFEGTQFGGA----------LMTTTEV 59 Query: 119 HSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTS 178 + +P + ++ R A +L ++ ++ Sbjct: 60 EN----------YPGFREGITGPELMDQMREQALRFGA----DLRMEDVDAVQ-----LE 100 Query: 179 DPKPTIEVSGKKYTAPHILIATGGMP---STPHESQIP--GASLGITSDGFFQLEELPGR 233 P T+ V + + A +++A G P E + G S T DGFF ++ Sbjct: 101 GPVKTVVVGDETHQARAVILAMGAAARHLGVPGEEALTGMGVSTCATCDGFFFRDQ---D 157 Query: 234 SVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFS 293 V+VG G A+E A L+ +L+ R D+ R+ M N + L + Sbjct: 158 IVVVGGGDSAMEEATFLTRFARSVTLIHRRDEF-RASKIM----LERARANEKITFLTNT 212 Query: 294 QVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDD 353 ++ +++ V + V G DV + AIG P ++ L + ++ DD Sbjct: 213 EITQIEGDPKVTGVRLRDTVTGEESK----LDVTGVFVAIGHDPRSE---LVRGQVELDD 265 Query: 354 KGHIIVD-EFQNTNVKGIYAVGDVCGKALL-TPVAIAAGRKLA 394 +G++ V T++ G++A GD+ A +G + Sbjct: 266 EGYVKVQGRTTYTSLDGVFAAGDLVDHTYRQAITAAGSGCAAS 308 >1F6M-A nrPDB Length = 320 Score = 191 bits (486), Expect = 6e-49, Method: Composition-based stats. Identities = 71/341 (20%), Positives = 116/341 (34%), Gaps = 55/341 (16%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDH 126 L++G G G +A AA + ++ + GG Sbjct: 8 LLILGSGPAGYTAAVYAARANLQPVLITGMEKGGQ--------------------LTTTT 47 Query: 127 ADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEV 186 +P ++ E+ + TK EII H + Sbjct: 48 EVENWPGDPNDLTGPLLMERMHEHA-----------TKFETEIIFDHINKVDLQNRPFRL 96 Query: 187 SGK--KYTAPHILIATGGMPST---PHESQIPG--ASLGITSDGFFQLEELPGRSVIVGA 239 +G +YT ++IATG P E G S T DGFF + + ++G Sbjct: 97 NGDNGEYTCDALIIATGASARYLGLPSEEAFKGRGVSASATCDGFFYRNQ---KVAVIGG 153 Query: 240 GYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVK 299 G AVE A LS + S+ L+ R D + ++ +++EN + + ++EV Sbjct: 154 GNTAVEEALYLSNIASEVHLIHRRDGF--RAEKILIKRLMDKVENGNIILHTNRTLEEVT 211 Query: 300 KTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIV 359 G+ + + + DV L AIG PNT G + G+I V Sbjct: 212 GDQMGVTGVRLRDTQNSDNIES--LDVAGLFVAIGHSPNTAIFE----GQLELENGYIKV 265 Query: 360 DEF-----QNTNVKGIYAVGDVCGKALL-TPVAIAAGRKLA 394 T++ G++A GDV + G A Sbjct: 266 QSGIHGNATQTSIPGVFAAGDVMDHIYRQAITSAGTGCMAA 306 >3ISH-A nrPDB Length = 311 Score = 187 bits (475), Expect = 1e-47, Method: Composition-based stats. Identities = 75/347 (21%), Positives = 117/347 (33%), Gaps = 48/347 (13%) Query: 66 DYLVIGGGSGGLASARRAAELGAR-AAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 D +IGGG GL++ A G + A + E GG + E Sbjct: 3 DCAIIGGGPAGLSAGLYATRGGVKNAVLFEKGMPGGQ------------ITGSSEIEN-- 48 Query: 125 DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTI 184 +P + + + R K + ++ + + Sbjct: 49 ------YPGVKEVVSGLDFMQPWQEQCFRFG-------LKHEMTAVQ-RVSKKDSHFVIL 94 Query: 185 EVSGKKYTAPHILIATGGMP---STPHESQI--PGASLGITSDGFFQLEELPGRSVIVGA 239 GK + A ++IATGG P ES+ G S T DGFF ++G Sbjct: 95 AEDGKTFEAKSVIIATGGSPKRTGIKGESEYWGKGVSTCATCDGFFYKN---KEVAVLGG 151 Query: 240 GYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVK 299 G AVE A L+ + K L+ R D N +E L V+E+K Sbjct: 152 GDTAVEEAIYLANICKKVYLIHRRDGF-----RCAPITLEHAKNNDKIEFLTPYVVEEIK 206 Query: 300 KTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNK--LGIQTDDKGHI 357 SG+ + ++P +G N L + + D+ G I Sbjct: 207 GDASGVSSLSIKNTATNEKRELVVPGF---FIFVGYDVNNAVLKQEDNSMLCKCDEYGSI 263 Query: 358 IVDEFQNTNVKGIYAVGDV-CGKALLTPVAIAAGRKLAHRLFEYKED 403 +VD TNV+G++A GD+ A + G A + Y E Sbjct: 264 VVDFSMKTNVQGLFAAGDIRIFAPKQVVCAASDGATAALSVISYLEH 310 >5YGQ-A nrPDB Length = 342 Score = 180 bits (456), Expect = 2e-45, Method: Composition-based stats. Identities = 76/353 (21%), Positives = 134/353 (37%), Gaps = 51/353 (14%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVES-HKLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 D L++G G GL + L +A +V+ K+GG C + P+K +++ Sbjct: 8 DVLIVGAGPCGLFAVFELGLLDVKAHLVDILDKVGGQCAEL--YPEKPIYDIP------- 58 Query: 125 DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTI 184 G P G + E+ + N + + ++E I DP + Sbjct: 59 -----GIPMVTGHGLTEALMEQ----IKPFNPTFHLSEMVENVEKI-------GDPGFRV 102 Query: 185 EVS-GKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELP----GRSVIVGA 239 + GK + +++A GG P +PG + + + ++ +IVG Sbjct: 103 TTNAGKVFECTVLVVAAGGGSFLPKRPPVPGVEAYEGTSVHYAVRKMEDFRGKDILIVGG 162 Query: 240 GYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVK 299 G A++ L+ + +L+ R D + S +L +G LK Q+ E++ Sbjct: 163 GDSALDWTLNLNPIAKSMTLVHRRDDFRGAPH---SVEQMRQLVASGKLDLKIGQITELQ 219 Query: 300 KT---LSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGH 356 L+G V + ++ M+P L +G V N G+ + Sbjct: 220 GDNGQLTGATVKLNDNTTSQIKCDAMLPFF-GLTMKLGPVANW--------GLDL-ENNL 269 Query: 357 IIVDE-FQNTNVKGIYAVGDVC---GKALLTPVAIAAGRKLAHRLFEYKEDSK 405 I VD TNV GI+A+GD+ GK L G +A + +Y K Sbjct: 270 IPVDTGTFETNVPGIFAIGDINTYPGKLKLILSGFHEGALMAQKAVKYVYPDK 322 >3F8P-A nrPDB Length = 323 Score = 178 bits (452), Expect = 4e-45, Method: Composition-based stats. Identities = 69/352 (19%), Positives = 117/352 (33%), Gaps = 58/352 (16%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 +D +++G G +A +A + V+ GG G V + S+ + Sbjct: 16 FDVIIVGLGPAAYGAALYSARYMLKTLVI-GETPGGQLTEAGIVDDYLGLIEIQASDMIK 74 Query: 125 DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTI 184 + + K + ++ + Sbjct: 75 VFNKH--------------------------------IEKYEVPVLLDIVEKIENRGDEF 102 Query: 185 EVSGK---KYTAPHILIATGGMP---STPHESQI--PGASLGITSDGFFQLEELPGRSVI 236 V K ++ A +++ G P E + G S D + + Sbjct: 103 VVKTKRKGEFKADSVILGIGVKRRKLGVPGEQEFAGRGISYCSVCDAPLFKNRV---VAV 159 Query: 237 VGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVK 296 +G G A+E A ILS+ +K L+ R D + VE + S VK Sbjct: 160 IGGGDSALEGAEILSSYSTKVYLIHRRDTF-----KAQPIYVETVKKKPNVEFVLNSVVK 214 Query: 297 EVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGH 356 E+K +V + G + +V+ + IG P T N GI+TD G+ Sbjct: 215 EIKGDKVVKQVVVENLKTGEIKE----LNVNGVFIEIGFDPPTDFAKSN--GIETDTNGY 268 Query: 357 IIVDEFQNTNVKGIYAVGDVCG---KALLTPVAIAAGRKLAHRLFEYKEDSK 405 I VDE+ T+V G++A GD A+A G A + Y + K Sbjct: 269 IKVDEWMRTSVPGVFAAGDCTSAWLGFRQVITAVAQGAVAATSAYRYVTEKK 320 >5U63-A nrPDB Length = 321 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 67/342 (19%), Positives = 118/342 (34%), Gaps = 58/342 (16%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDH 126 L++G G G +A AA + +V + GG T E Sbjct: 12 LLILGSGPAGYTAAIYAARANLKPVLVTGLQQGGQ------------LTTTDEIEN---- 55 Query: 127 ADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEV 186 +P + ++ + + EI+ H ++ Sbjct: 56 ----WPGDFEMTTGSGLMQRMLQHAEKF-----------ETEIVFDHINRVDLSSRPFKL 100 Query: 187 SG--KKYTAPHILIATGGMPST---PHESQIPG--ASLGITSDGFFQLEELPGRSVIVGA 239 G + +T ++IATG P E G S T DGFF + ++G Sbjct: 101 FGDVQNFTCDALIIATGASARYIGLPSEENYKGRGVSACATCDGFFYRNKP---VGVIGG 157 Query: 240 GYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVK 299 G AVE A L+ + S L+ R D + ++ +++E + + + EV Sbjct: 158 GNTAVEEALYLANIASTVHLIHRRDSF--RAEKILIDRLYKKVEEGKIVLHTDRTLDEVL 215 Query: 300 KTLSGLE-VSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHII 358 G+ + + G + + D L AIG PNT+ + ++ + G+I+ Sbjct: 216 GDNMGVTGLRLANTKTGEKEELKL----DGLFVAIGHSPNTEIF---QGQLELN-NGYIV 267 Query: 359 VDEF-----QNTNVKGIYAVGDVCGKALL-TPVAIAAGRKLA 394 V T+V+G++A GDV + G A Sbjct: 268 VKSGLDGNATATSVEGVFAAGDVMDHNYRQAITSAGTGCMAA 309 >2A87-A nrPDB Length = 335 Score = 176 bits (446), Expect = 3e-44, Method: Composition-based stats. Identities = 76/355 (21%), Positives = 125/355 (35%), Gaps = 58/355 (16%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHD 125 D +VIG G G +A AA V E GG +M T V + Sbjct: 16 DVIVIGSGPAGYTAALYAARAQLAPLVFEGTSFGGA----------LMTTTDVEN----- 60 Query: 126 HADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIE 185 +P + ++ R A +L +E + H K + Sbjct: 61 -----YPGFRNGITGPELMDEMREQALRFGA----DLRMEDVESVSLHGPL----KSVVT 107 Query: 186 VSGKKYTAPHILIATGGMPST---PHESQI--PGASLGITSDGFFQLEELPGRSVIVGAG 240 G+ + A +++A G P E ++ G S T DGFF ++ ++G G Sbjct: 108 ADGQTHRARAVILAMGAAARYLQVPGEQELLGRGVSSCATCDGFFFRDQ---DIAVIGGG 164 Query: 241 YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK 300 A+E A L+ +L+ R D+ R+ M+ N + L V V Sbjct: 165 DSAMEEATFLTRFARSVTLVHRRDEF-RASKIMLD----RARNNDKIRFLTNHTVVAVDG 219 Query: 301 TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD 360 + + + G + V + AIG P + L + I D G+++V Sbjct: 220 DTTVTGLRVRDTNTGAETTLP----VTGVFVAIGHEPRS---GLVREAIDVDPDGYVLVQ 272 Query: 361 -EFQNTNVKGIYAVGDVCGKALLTPV---------AIAAGRKLAHRLFEYKEDSK 405 +T++ G++A GD+ + V AI A R LA + DS Sbjct: 273 GRTTSTSLPGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHAATGEADST 327 >5USX-A nrPDB Length = 319 Score = 174 bits (441), Expect = 9e-44, Method: Composition-based stats. Identities = 68/342 (19%), Positives = 111/342 (32%), Gaps = 58/342 (16%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDH 126 L++G G G +A AA ++ + GG Sbjct: 9 LLILGSGPAGYTAAVYAARANLNPVLITGMQQGGQ--------------------LTTTT 48 Query: 127 ADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEV 186 +P + ++ + R EII H + Sbjct: 49 EVENWPGDPEGLTGPGLMDRMKEHAERF-----------ETEIIFDHINEVDFSTRPFVL 97 Query: 187 SGK--KYTAPHILIATGGMPST-----PHESQIPGASLGITSDGFFQLEELPGRSVIVGA 239 G Y+ ++I+TG + G S T DGFF + + +VG Sbjct: 98 KGDAASYSCDALIISTGASAKYLGLESEEAFKGRGVSACATCDGFFYRNQ---KVAVVGG 154 Query: 240 GYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVK 299 G AVE A LS + ++ L+ R D + ++ ++++N + + + EV Sbjct: 155 GNTAVEEALYLSNIAAEVHLIHRRDSF--RAEKILINRLMDKVQNGNIVLHTDRVLDEVL 212 Query: 300 KTLSGLE-VSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHII 358 G+ V + G T DV AIG PNT+ G G+I+ Sbjct: 213 GDEMGVTGVRLKDVKTG----GTEELDVMGAFIAIGHSPNTQIFQ----GQLDMKDGYIL 264 Query: 359 VDEF-----QNTNVKGIYAVGDVCGKALL-TPVAIAAGRKLA 394 V T+V+GI+A GDV + G A Sbjct: 265 VKSGLEGNATQTSVEGIFAAGDVMDHNYRQAITSAGTGCMAA 306 >4FX9-A nrPDB Length = 453 Score = 172 bits (435), Expect = 4e-43, Method: Composition-based stats. Identities = 79/366 (21%), Positives = 142/366 (38%), Gaps = 38/366 (10%) Query: 159 QNNLTKSHIEI-IRGHAAFTSDPKPTIEVSG--KKYTAPHILIATGGMPSTPHESQI--P 213 + + K I++ + + +G K Y +++ A G P P + Sbjct: 69 EVFIKKRGIDLHLNAEVIEVDTGYVRVRENGGEKSYEWDYLVFANGASPQVPAIEGVNLK 128 Query: 214 GASLGITSDGFFQLEELPGR-----SVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLR 268 G + E + VI+G GYI +EMA +A G ++++R ++VLR Sbjct: 129 GVFTADLPPDALAIREYMEKYKVENVVIIGGGYIGIEMAEAFAAQGKNVTMIVRGERVLR 188 Query: 269 -SFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVD 327 SFD ++ E+L+ V + +++ V V G + Sbjct: 189 RSFDKEVTDILEEKLKKH-VNLRLQEITMKIEGEE---RVEKVVTDAGEYK-------AE 237 Query: 328 CLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDV-------CGKA 380 ++ A G PN + +LG++ + G I +E T+V+ +YA GDV G+ Sbjct: 238 LVILATGIKPNIE--LAKQLGVRIGETGAIWTNEKMQTSVENVYAAGDVAETRHVITGRR 295 Query: 381 LLTPVAIAAGRKLAHRLFEYKEDSKLDYNNI---PTVVFSHPPIGTVGLTEDEAIHKYGI 437 + P+A AG K+ + +L + + F IG GLTE EA+ + Sbjct: 296 VWVPLA-PAGNKMGYVAGSNIAGKELHFPGVLGTAVTKFMDVEIGKTGLTEMEALKEGYD 354 Query: 438 ENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKM 497 S P Y+ + +K V N+ +++G+ + G + A + Sbjct: 355 VRTAFIKASTRPHYYP---GGREIWLKGVVDNETNRLLGVQVVGSDILPRIDTAAAMLMA 411 Query: 498 GATKAD 503 G T D Sbjct: 412 GFTTKD 417 >3LZX-A nrPDB Length = 332 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 74/348 (21%), Positives = 131/348 (37%), Gaps = 46/348 (13%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVNVGCVPKKVMWNTAVHSEFM 123 YD +IGGG GL +A A ++ES +LGG P+K +++ A Sbjct: 8 YDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGGQLS--ALYPEKYIYDVA------ 59 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 GFP + +KE+ + Q + +E + A D Sbjct: 60 ------GFPKIRAQELINNLKEQ-------MAKFDQTICLEQAVESVEKQA----DGVFK 102 Query: 184 IEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPG----RSVIVGA 239 + + + + + ++I G P + ++ A + + +++L R I+G Sbjct: 103 LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAILGG 162 Query: 240 GYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVK 299 G AV+ A +L + + S++ R DK + E L + V VL E+ Sbjct: 163 GDSAVDWALMLEPIAKEVSIIHRRDKF------RAHEHSVENLHASKVNVLTPFVPAELI 216 Query: 300 KTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIV 359 +E ++ V G I ++D L+ G V + + L I +K I+V Sbjct: 217 G-EDKIEQLVLEEVKGDRKE---ILEIDDLIVNYGFVSSLGPIKNWGLDI---EKNSIVV 269 Query: 360 DEFQNTNVKGIYAVGDVC---GKALLTPVAIAAGRKLAHRLFEYKEDS 404 TN++G +A GD+C GK L + Y + Sbjct: 270 KSTMETNIEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPK 317 >4CBQ-A nrPDB Length = 314 Score = 169 bits (428), Expect = 3e-42, Method: Composition-based stats. Identities = 78/339 (23%), Positives = 128/339 (37%), Gaps = 48/339 (14%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 +D ++IG G +A + + E GG + Sbjct: 5 HDVVIIGSGPAAHTAAIYLGRSSLKPVMYEGFMAGGVAA------------GGQLTTTTI 52 Query: 125 DHADYGFP-SCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 GFP +G ++ + + Y + + I H F++ P Sbjct: 53 IENFPGFPNGIDGNELMMNMRTQSEKYGTTI------------ITETIDHVDFSTQPFKL 100 Query: 184 IEVSGKKYTAPHILIATGGMPS---TPHESQI--PGASLGITSDGFFQLEELPGRSV-IV 237 GK+ ++IATG P E + G S DG + + + +V Sbjct: 101 FTEEGKEVLTKSVIIATGATAKRMHVPGEDKYWQNGVSACAICDGA--VPIFRNKVLMVV 158 Query: 238 GAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKE 297 G G A+E A L+ GSK ++ R D R+ +M L + +EV+ S++ E Sbjct: 159 GGGDAAMEEALHLTKYGSKVIILHRRD-AFRASKTM----QERVLNHPKIEVIWNSELVE 213 Query: 298 VKKTLSGLE-VSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGH 356 ++ L + V G V+ V L +AIG PN+K L ++T D G+ Sbjct: 214 LEGDGDLLNGAKIHNLVSGEYKVVP----VAGLFYAIGHSPNSKFLG---GQVKTADDGY 266 Query: 357 IIVDEFQNTNVKGIYAVGDVCGKALL-TPVAIAAGRKLA 394 I+ E T+V G++A GDVC + VA +G A Sbjct: 267 ILT-EGPKTSVDGVFACGDVCDRVYRQAIVAAGSGCMAA 304 >3NTA-A nrPDB Length = 574 Score = 165 bits (418), Expect = 5e-41, Method: Composition-based stats. Identities = 90/400 (22%), Positives = 155/400 (38%), Gaps = 58/400 (14%) Query: 143 IKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYT--APHILIAT 200 + + +++ +R N + K + I A + G +Y +L++ Sbjct: 60 VLQTPESFKARFNVEVRV---KHEVVAIDRAAKLV---TVRRLLDGSEYQESYDTLLLSP 113 Query: 201 GGMPSTPHESQIPGASLGITSDGFFQLEELP--------------GRSVIVGAGYIAVEM 246 G P P IPG +T L +P + +VG G+I +EM Sbjct: 114 GAAPIVP---PIPGVDNPLTH----SLRNIPDMDRILQTIQMNNVEHATVVGGGFIGLEM 166 Query: 247 AGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVK------- 299 L LG KT+L+ D+V+ D ++ + + + GV++ + + EV Sbjct: 167 MESLHHLGIKTTLLELADQVMTPVDREMAGFAHQAIRDQGVDLRLGTALSEVSYQVQTHV 226 Query: 300 KTLSGLEVSMVTAVPGRLPVM---TMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGH 356 + + E + + G L + + + D L+ AIG P T+ G+ + G Sbjct: 227 ASDAAGEDTAHQHIKGHLSLTLSNGELLETDLLIMAIGVRPETQ--LARDAGLAIGELGG 284 Query: 357 IIVDEFQNTNVKGIYAVGD-------VCGKALLTPVAIAA---GRKLAHRLFEYKEDSKL 406 I V+ T+ IYAVGD V G+A L P+A A GR A +F +E + Sbjct: 285 IKVNAMMQTSDPAIYAVGDAVEEQDFVTGQACLVPLAGPANRQGRMAADNMFGREERYQG 344 Query: 407 DYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTY-STSFTPMYHAVTKRKTKCVMKM 465 VF +G G E + + + GI K Y T+ Y+ + + K+ Sbjct: 345 TQGTAICKVF-DLAVGATGKNEKQ-LKQAGIAFEKVYVHTASHASYYPGAEVVS---FKL 399 Query: 466 VCANKEEKVVGIHMQG-LGCDEMLQGFAVAVKMGATKADF 504 + + + G G G D+ + AVA + G T Sbjct: 400 LFDPVKGTIFGAQAVGKDGIDKRIDVMAVAQRAGMTVEQL 439 >2BC1-A nrPDB Length = 490 Score = 165 bits (417), Expect = 6e-41, Method: Composition-based stats. Identities = 76/366 (20%), Positives = 131/366 (35%), Gaps = 56/366 (15%) Query: 178 SDPKPTIEVSGKKY--TAPHILIATGGMPSTPHESQIPGASLGITSDGF----------- 224 T V GK + T ++ ATG P P I GA + S F Sbjct: 121 DAKTVTALVDGKNHVETYDKLIFATGSQPILP---PIKGAEIKEGSLEFEATLENLQFVK 177 Query: 225 -----------FQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRS-FDS 272 + +++ R +VGAGYI VE+A G + L+ D L +D Sbjct: 178 LYQNSADVIAKLENKDI-KRVAVVGAGYIGVELAEAFQRKGKEVVLIDVVDTCLAGYYDR 236 Query: 273 MISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWA 332 ++ + +E G+++ VKEV ++ DVD ++ A Sbjct: 237 DLTDLMAKNMEEHGIQLAFGETVKEVAGNGKVEKIITDKNE----------YDVDMVILA 286 Query: 333 IGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDV----------CGKALL 382 +G PNT L I G +V++ Q T++ G+YA+GD L Sbjct: 287 VGFRPNTT---LGNGKIDLFRNGAFLVNKRQETSIPGVYAIGDCATIYDNATRDTNYIAL 343 Query: 383 TPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKT 442 A+ G AH + + ++ + + GLT ++A V Sbjct: 344 ASNAVRTGIVAAHNACGTDLEGIGVQGSNGISIYG-LHMVSTGLTLEKAKRLGFDAAVTE 402 Query: 443 YSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQG-LGCDEMLQGFAVAVKMGATK 501 Y+ + P + + +K+V +++G M + F++A++ G T Sbjct: 403 YTDNQKPEF--IEHGNFPVTIKIVYDKDSRRILGAQMAAREDVSMGIHMFSLAIQEGVTI 460 Query: 502 ADFDNT 507 T Sbjct: 461 EKLALT 466 >3R9U-A nrPDB Length = 315 Score = 162 bits (411), Expect = 3e-40, Method: Composition-based stats. Identities = 71/355 (20%), Positives = 117/355 (32%), Gaps = 50/355 (14%) Query: 61 AVASYDYLVIGGGSGGLASARRAAELGAR-AAVVESHKLGGTCVNVGCVPKKVMWNTAVH 119 + A D +IGGG GL++ A G + + E GG ++ Sbjct: 1 SNAMLDVAIIGGGPAGLSAGLYATRGGLKNVVMFEKGMPGGQ------------ITSSSE 48 Query: 120 SEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSD 179 E +P + R ++ +E I SD Sbjct: 49 IEN--------YPGVAQVMDGISFMAPWSEQCMRFGLKHE----MVGVEQIL----KNSD 92 Query: 180 PKPTIEVSGKKYT-APHILIATGGMPSTPHESQ-----IPGASLGITSDGFFQLEELPGR 233 TI++ G K A +++ TG P G S T DGFF Sbjct: 93 GSFTIKLEGGKTELAKAVIVCTGSAPKKAGFKGEDEFFGKGVSTCATCDGFFYKN---KE 149 Query: 234 SVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFS 293 ++G G A+E A L+ + SK L+ R D+ + + +N +E++ + Sbjct: 150 VAVLGGGDTALEEALYLANICSKIYLIHRRDEF-----RAAPSTVEKVKKNEKIELITSA 204 Query: 294 QVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLG--IQT 351 V EV G+ V G + +V + +G + L + Sbjct: 205 SVDEVYGDKMGVAGVKVKLKDGSIRD----LNVPGIFTFVGLNVRNEILKQDDSKFLCNM 260 Query: 352 DDKGHIIVDEFQNTNVKGIYAVGDVC-GKALLTPVAIAAGRKLAHRLFEYKEDSK 405 ++ G + VD T+V G++A GD+ A G A Y E Sbjct: 261 EEGGQVSVDLKMQTSVAGLFAAGDLRKDAPKQVICAAGDGAVAALSAMAYIESLH 315 >5ER0-A nrPDB Length = 518 Score = 161 bits (408), Expect = 7e-40, Method: Composition-based stats. Identities = 64/369 (17%), Positives = 118/369 (31%), Gaps = 70/369 (18%) Query: 177 TSDPKPTIEVSGKKY------TAPHILIATGGMPSTPHESQIPGASLGITSD-----GFF 225 + T+ V + +++ +G P P I + + + Sbjct: 132 IDPDQKTVTVEDLTNHAQTTESYDKLVMTSGSWPIVPKIPGIDSDRVKLCKNWAHAQALI 191 Query: 226 QLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLR-SFDSMISTNCTEELEN 284 + + R ++GAGYI E+A S G +L+ +V+ FD+ + ++ + Sbjct: 192 EDAKEAKRITVIGAGYIGAELAEAYSTTGHDVTLIDAMARVMPKYFDADFTDVIEQDYRD 251 Query: 285 AGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSL 344 GV++ V+ + +GL + + D + IG PNT L Sbjct: 252 HGVQLALGETVESFTDSATGLTIKTDKN----------SYETDLAILCIGFRPNTDLL-- 299 Query: 345 NKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGK----------ALLTPVAIAAGRKLA 394 K + G II D++ ++ I+A GD L A+ G + Sbjct: 300 -KGKVDMAPNGAIITDDYMRSSNPDIFAAGDSAAVHYNPTHQNAYIPLATNAVRQGILVG 358 Query: 395 HRLFEYKEDSKLDYNNIPTVVFS-----------HPPIGTVGLTEDEAIHKY-GIENVKT 442 L + PTV + I + GLT A + E V Sbjct: 359 KNLVK------------PTVKYMGTQSSSGLALYDRTIVSTGLTLAAAKQQGLNAEQVIV 406 Query: 443 ---YSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQG-LGCDEMLQGFAVAVKMG 498 Y F P +M +V +++G + + +V ++ Sbjct: 407 EDNYRPEFMP-------STEPVLMSLVFDPDTHRILGGALMSKYDVSQSANTLSVCIQNE 459 Query: 499 ATKADFDNT 507 T D Sbjct: 460 NTIDDLAMV 468 >4YRY-B nrPDB Length = 468 Score = 159 bits (402), Expect = 3e-39, Method: Composition-based stats. Identities = 88/407 (21%), Positives = 147/407 (36%), Gaps = 87/407 (21%) Query: 32 EPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAA 91 EP A+ R E + P AG+ V+G G GL +A A++G Sbjct: 109 EPVAIGRLERFVADWAAENLEEDVKPLAGSKKE-KVAVVGSGPAGLTAAADLAKMGYHVD 167 Query: 92 VVES-HKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAY 150 + E+ HK GG V YG P + I E+ +Y Sbjct: 168 IFEAFHKPGGVLV-------------------------YGIPEFRLP---KRIVEREVSY 199 Query: 151 VSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHES 210 + +L + H+ + G T++V + I TG TP Sbjct: 200 IRKLGVNF-------HLNTVVG---------KTVKVKELLSEYDAVFIGTGA--GTPKFM 241 Query: 211 QIPGASL-GITSDGFFQLE----------------ELPGRSVIVGAGYIAVEMAGILSAL 253 IPG +L G+ S F + + ++GAG A++ A L Sbjct: 242 GIPGTNLNGVYSANEFLTRVNLMKAYLFPEYDTPIRVGKKVAVIGAGNTAMDAARSALRL 301 Query: 254 GS-KTSLMIRH-DKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSG------- 304 G+ K ++ R ++ + + G+E L + +G Sbjct: 302 GAEKVYIVYRRTEREMPA-----RREEYHHALEEGIEFLWLTLPIRYIGDANGNVEAMEC 356 Query: 305 --LEVSMVTAVPGRLPV----MTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHII 358 +E+ PV + +VD ++ AIG+ PN + L G++ +++G+I Sbjct: 357 VRMELKEADGSGRPRPVPIEGSNFVLEVDMVIEAIGQGPN-RVLLSEFPGLELNERGYIK 415 Query: 359 VDEFQ-NTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDS 404 DE T+VKG++A GD+ A A+ AG+K A + Y Sbjct: 416 ADEDTGATSVKGVFAGGDIVTGAATVIKAMGAGKKAAQFIHSYLTGE 462 >3ICS-A nrPDB Length = 588 Score = 155 bits (393), Expect = 4e-38, Method: Composition-based stats. Identities = 78/387 (20%), Positives = 139/387 (35%), Gaps = 47/387 (12%) Query: 141 RVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYT--APHILI 198 +++ + + R N + S + I + T + + Y +++ Sbjct: 93 KLLVQTVERMSKRFNLDIRVL---SEVVKINKEEKTITIKNVT---TNETYNEAYDVLIL 146 Query: 199 ATGGMPSTPHESQIPGASLGITSDG--------FFQLEELPGRSVIVGAGYIAVEMAGIL 250 + G P P I A T + E+ P + ++G G+I VEM L Sbjct: 147 SPGAKPIVPSIPGIEEAKALFTLRNVPDTDRIKAYIDEKKPRHATVIGGGFIGVEMVENL 206 Query: 251 SALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMV 310 G + +L+ ++V+ D ++ E ++N VE++ V +++ + + + Sbjct: 207 RERGIEVTLVEMANQVMPPIDYEMAAYVHEHMKNHDVELVFEDGVDALEENGAVVRLK-- 264 Query: 311 TAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGI 370 + D L+ AIG P + G+ +G I V+E T+ I Sbjct: 265 ---------SGSVIQTDMLILAIGVQPESS--LAKGAGLALGVRGTIKVNEKFQTSDPHI 313 Query: 371 YAVGD-------VCGKALLTPVAIAA---GRKLAHRLFEYKEDS-KLDYNNIPTVVFSHP 419 YA+GD V + P+A A GR LA + + + K VF Sbjct: 314 YAIGDAIEVKDFVTETETMIPLAWPANRQGRMLADIIHGHTDSLYKGTLGTSVAKVF-DL 372 Query: 420 PIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTK-RKTKCVMKMVCANKEEKVVGIH 478 + T GL E I K + HA T ++K++ K+ G Sbjct: 373 TVATTGLNEK--ILKRLNIPYEVVHV--QANSHAGYYPNATPVLIKLIFNKDSGKIYGAQ 428 Query: 479 MQG-LGCDEMLQGFAVAVKMGATKADF 504 G G D+ + A A+K T D Sbjct: 429 TLGRDGVDKRMDVIATAIKANLTVLDL 455 >6GAS-A nrPDB Length = 331 Score = 155 bits (391), Expect = 6e-38, Method: Composition-based stats. Identities = 69/350 (19%), Positives = 125/350 (35%), Gaps = 46/350 (13%) Query: 59 AGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVNVGCVPKKVMWNTA 117 A YD +IGGG GL +A A ++ES +LGG P+K +++ A Sbjct: 4 AENQKVYDITIIGGGPTGLFTAFYGGMRQASVKIIESLPQLGGQLS--ALYPEKYIYDVA 61 Query: 118 VHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFT 177 GFP + +KE+ + + ++ + A Sbjct: 62 ------------GFPKVRAQELVDNLKEQMKKF-------DPTVCLEEAVDTLEKQA--- 99 Query: 178 SDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPG----R 233 D + + + + + ++I G P ++ G + + + ++++ R Sbjct: 100 -DGIFKLVTNKQTHYSKSVIITAGNGAFQPRRLELEGTAKYEKKNLHYFVDDMNKFAGKR 158 Query: 234 SVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFS 293 V+ G G AV+ +L + K +++ R DK + E L N+ EV Sbjct: 159 VVVFGGGDSAVDWTMMLEPIAEKVTIVHRRDKF------RAHEHSVENLMNSRAEVSTPY 212 Query: 294 QVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDD 353 E+ +V + ++ + + G V + + L IQ Sbjct: 213 VPVELIGDDKIEQVVLQHVKTEEKVIIDVDDVI----VNYGFVSSLGPIKNWGLDIQ--- 265 Query: 354 KGHIIVDEFQNTNVKGIYAVGDVC---GKALLTPVAIAAGRKLAHRLFEY 400 K I+V+ TN+ GIYA GD+C GK L + Y Sbjct: 266 KNSILVNSKMETNIPGIYAAGDICTYEGKVKLIACGFGEAPTAVNNAKAY 315 >5JFC-L nrPDB Length = 474 Score = 152 bits (383), Expect = 5e-37, Method: Composition-based stats. Identities = 77/369 (20%), Positives = 124/369 (33%), Gaps = 81/369 (21%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVES-HKLGGTCVNVGCVPKKVMWNTAVHSEFMHD 125 +IG G GL A A++G + E+ H+ GG + Sbjct: 157 VAIIGAGPAGLTCAADLAKMGYEVTIYEALHQPGGVLI---------------------- 194 Query: 126 HADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIE 185 YG P + I +K + RL + N+ TI Sbjct: 195 ---YGIPEFRLP---KEIVKKELENLRRLGVKIETNVLVGK----------------TIT 232 Query: 186 VSGKKYTAPHILIATGGMPSTPHESQIPGASL-GITSDGFFQLE---------------- 228 + I I TG TP PG +L GI S F Sbjct: 233 FEELREEYDAIFIGTGA--GTPRIYPWPGVNLNGIYSANEFLTRINLMKAYKFPEYDTPI 290 Query: 229 ELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVE 288 ++ R ++G G A++ A LG++ ++ R + + + E GV+ Sbjct: 291 KVGKRVAVIGGGNTAMDAARSALRLGAEVWILYRRTR----KEMTAREEEIKHAEEEGVK 346 Query: 289 VLKFSQVKEVKKTLSGL--EVSMVTAVPGRLPV----------MTMIPDVDCLLWAIGRV 336 + K +G + + G T I + D + AIG+ Sbjct: 347 FMFLVTPKRFIGDENGNLKAIELEKMKLGEPDESGRRRPIPTGETFIMEFDTAIIAIGQT 406 Query: 337 PNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHR 396 PN L G++ D+ G I+VDE T++ G++A GD +A+ GRK A Sbjct: 407 PNKTFLETV-PGLKVDEWGRIVVDENLMTSIPGVFAGGDAIRGEATVILAMGDGRKAAKA 465 Query: 397 LFEYKEDSK 405 + +Y K Sbjct: 466 IHQYLSKEK 474 >5W4C-A nrPDB Length = 371 Score = 152 bits (383), Expect = 6e-37, Method: Composition-based stats. Identities = 77/349 (22%), Positives = 118/349 (33%), Gaps = 40/349 (11%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDH 126 ++IG G GG +A A + E G N G P + T Sbjct: 33 VVIIGSGPGGHTAAIYLARANLEPVLYE-----GMLAN-GFAPGGQLTTTTDVEN----- 81 Query: 127 ADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEV 186 FP + +K A R + + E Sbjct: 82 ----FPGFPEGVTGTEMMDKFRAQSERFGTKIIT----ETVARVDLSVRPFKYWTEGEEE 133 Query: 187 SGKKYTAPHILIATGGMP---STPHESQI--PGASLGITSDGFFQLEELPGRSVIVGAGY 241 + TA I++ATG P E G S DG + ++G G Sbjct: 134 EHEFMTADTIILATGASAKRLFLPGEETYWQSGISACAVCDGAVPIFRQ-KPLAVIGGGD 192 Query: 242 IAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKT 301 A E A L+ GS +++R D+ LR+ +++ T + V VL + E K Sbjct: 193 SAAEEATYLTKYGSHVYVLVRRDE-LRAS-KIMAKRLT---SHPKVTVLWNTVATEAKGD 247 Query: 302 LSGLE-VSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHII-V 359 L +++ G T V+ L +AIG P T SL K ++ D G+I V Sbjct: 248 GEVLTSLTIKNTKTGE----TGDLPVNGLFYAIGHEPAT---SLVKSQVELDSDGYIKTV 300 Query: 360 DEFQNTNVKGIYAVGDVCGKALL-TPVAIAAGRKLAHRLFEYKEDSKLD 407 T+V G++A GDV K + +G A + + D Sbjct: 301 PGTSQTSVHGVFAAGDVQDKKYRQAITSAGSGCIAALEAERLISEEEAD 349 >1NHQ-A nrPDB Length = 447 Score = 150 bits (380), Expect = 1e-36, Method: Composition-based stats. Identities = 72/400 (18%), Positives = 135/400 (33%), Gaps = 69/400 (17%) Query: 145 EKRDAYVSRLNAIYQNNLTKSHIEII-RGHAAFTSDPKPTIEVSG-----KKYT-APHIL 197 E + V+ + + + + + + + V ++ ++ Sbjct: 49 EGKVKDVNSVRYMTGEKMESRGVNVFSNTEITAIQPKEHQVTVKDLVSGEERVENYDKLI 108 Query: 198 IATGGMPSTPHESQIPGASLGITSDGFFQLE------ELPGR--------SVIVGAGYIA 243 I+ G P E IPG L D + + +L + V++G+GYI Sbjct: 109 ISPGA---VPFELDIPGKDL----DNIYLMRGRQWAIKLKQKTVDPEVNNVVVIGSGYIG 161 Query: 244 VEMAGILSALGSKTSLMIRHDKVLRSF-DSMISTNCTEELENAGVEVLKFSQVKEVKKTL 302 +E A + G K +++ D+ L + D + TEE+E + + V+ + Sbjct: 162 IEAAEAFAKAGKKVTVIDILDRPLGVYLDKEFTDVLTEEMEANNITIATGETVERYEGDG 221 Query: 303 SGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEF 362 +V D D ++ A+G PNT L K ++ G I DE+ Sbjct: 222 RVQKVVTDKN----------AYDADLVVVAVGVRPNTAWL---KGTLELHPNGLIKTDEY 268 Query: 363 QNTNVKGIYAVGDVCG----------KALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIP 412 T+ ++AVGD L A GR L E + + Sbjct: 269 MRTSEPDVFAVGDATLIKYNPADTEVNIALATNARKQGRFAVKNLEEPVKPFPGVQGSSG 328 Query: 413 TVVFSHPPIGTVGLTEDEAIHKY----GIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCA 468 VF + G+ E A + V+ Y F P K K K+V Sbjct: 329 LAVF-DYKFASTGINEVMAQKLGKETKAVTVVEDYLMDFNP-------DKQKAWFKLVYD 380 Query: 469 NKEEKVVGIHMQGLGCDEM---LQGFAVAVKMGATKADFD 505 + +++G + ++ + ++A++ T D Sbjct: 381 PETTQILGAQLM--SKADLTANINAISLAIQAKMTIEDLA 418 Score = 35.7 bits (81), Expect = 0.058, Method: Composition-based stats. Identities = 23/142 (16%), Positives = 41/142 (28%), Gaps = 45/142 (31%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVES-HKLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 + +VIG G G+ +A A+ G + V++ + G ++ Sbjct: 151 NVVVIGSGYIGIEAAEAFAKAGKKVTVIDILDRPLGVYLD-------------------- 190 Query: 125 DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTI 184 KE D + A T +E G + Sbjct: 191 -------------------KEFTDVLTEEMEANNITIATGETVERYEG-----DGRVQKV 226 Query: 185 EVSGKKYTAPHILIATGGMPST 206 Y A +++A G P+T Sbjct: 227 VTDKNAYDADLVVVAVGVRPNT 248 >3D8X-A nrPDB Length = 326 Score = 146 bits (370), Expect = 2e-35, Method: Composition-based stats. Identities = 73/351 (20%), Positives = 116/351 (33%), Gaps = 53/351 (15%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDH 126 +IG G +A A + + E G + + Sbjct: 13 VTIIGSGPAAHTAAIYLARAEIKPILYEGMMANG------------IAAGGQLTTTTEIE 60 Query: 127 ADYGFPSC-EGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIE 185 GFP G ++E+ TK EII + + Sbjct: 61 NFPGFPDGLTGSELMDRMREQS---------------TKFGTEIITETVSKVDLSSKPFK 105 Query: 186 V------SGKKYTAPHILIATGGMPS---TPHESQI--PGASLGITSDGFFQLEELPGRS 234 + + T I++ATG P E G S DG + Sbjct: 106 LWTEFNEDAEPVTTDAIILATGASAKRMHLPGEETYWQKGISACAVCDGAVPIFR-NKPL 164 Query: 235 VIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQ 294 ++G G A E A L+ GSK +++R D LR+ M +N +E+L + Sbjct: 165 AVIGGGDSACEEAQFLTKYGSKVFMLVRKDH-LRASTIM----QKRAEKNEKIEILYNTV 219 Query: 295 VKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDK 354 E K G ++ + + T +P V L +AIG P TK ++ + TD+ Sbjct: 220 ALEAKG--DGKLLNALRIKNTKKNEETDLP-VSGLFYAIGHTPATKIVA---GQVDTDEA 273 Query: 355 GHII-VDEFQNTNVKGIYAVGDVCGKALL-TPVAIAAGRKLAHRLFEYKED 403 G+I V T+V G +A GDV + +G A +Y Sbjct: 274 GYIKTVPGSSLTSVPGFFAAGDVQDSKYRQAITSAGSGCMAALDAEKYLTS 324 >2CDU-A nrPDB Length = 452 Score = 145 bits (365), Expect = 6e-35, Method: Composition-based stats. Identities = 70/355 (19%), Positives = 125/355 (35%), Gaps = 41/355 (11%) Query: 177 TSDPKPTIEVSG------KKYTAPHILIATGGMPSTPHESQIPGASLGIT---SDGFFQL 227 TI+V K +++ TG P+ P I + + + +D Sbjct: 84 VDPETKTIKVKDLITNEEKTEAYDKLIMTTGSKPTVPPIPGIDSSRVYLCKNYNDAKKLF 143 Query: 228 EELPG--RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVL-RSFDSMISTNCTEELEN 284 EE P I+G+GYI E+A S +L+ H++VL + FD + ++ E Sbjct: 144 EEAPKAKTITIIGSGYIGAELAEAYSNQNYNVNLIDGHERVLYKYFDKEFTDILAKDYEA 203 Query: 285 AGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSL 344 GV ++ S+V ++ + + D + IG PNT+ L Sbjct: 204 HGVNLVLGSKVAAFEEVDDEIITKTLDGKE---------IKSDIAILCIGFRPNTELL-- 252 Query: 345 NKLGIQTDDKGHIIVDEFQNTNVKGIYAVGD---VCGKA-------LLTPVAIAAGRKLA 394 K + D G II DE+ +++ + I+A GD V L A+ GR + Sbjct: 253 -KGKVAMLDNGAIITDEYMHSSNRDIFAAGDSAAVHYNPTNSNAYIPLATNAVRQGRLVG 311 Query: 395 HRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHA- 453 L E K ++ ++ + G+ A N+K Y Sbjct: 312 LNLTEDKVKDMGTQSSSGLKLYGR-TYVSTGINTALAKA----NNLKVSEVIIADNYRPE 366 Query: 454 VTKRKTKCVMKMVCANKEEKVVGIHMQG-LGCDEMLQGFAVAVKMGATKADFDNT 507 + +M +V K ++G + + +V ++ T D Sbjct: 367 FMLSTDEVLMSLVYDPKTRVILGGALSSMHDVSQSANVLSVCIQNKNTIDDLAMV 421 >4JNQ-A nrPDB Length = 345 Score = 145 bits (365), Expect = 7e-35, Method: Composition-based stats. Identities = 77/357 (21%), Positives = 114/357 (31%), Gaps = 53/357 (14%) Query: 49 EPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCV 108 E Q QGP + +VIG G G +A AA + V+ + GG Sbjct: 13 EAQTQGP--GSMTQRHAPVIVIGSGPAGYTAAIYAARAMLKPVVIAGLQQGGQ------- 63 Query: 109 PKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIE 168 +M T V + +P + E+ + A + Sbjct: 64 ---LMITTDVEN----------YPGYAEPVQGPWMMEQMARQAENVGAQI--------VH 102 Query: 169 IIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPST-----PHESQIPGASLGITSDG 223 I T P SG YT ++IATG G S T DG Sbjct: 103 DIITEVETTVRPFRLKGDSGTIYTCDALIIATGAQAKWLGLESEQTFMGGGVSACATCDG 162 Query: 224 FFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELE 283 FF + AVE A LS + +++ R D + ++ L Sbjct: 163 FFYRGKDVVVVGGG---NTAVEEALYLSHIAKSVTIVHRRDGF--RAEKIMQDRL---LS 214 Query: 284 NAGVEVLKFSQVKEVKKTL----SGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNT 339 V V+ S + E+ T G V+ V + T + AIG P Sbjct: 215 RENVSVVWNSVIDEILGTEARPPMGATVTGVRLKN-IVTGETQERATHGVFIAIGHAPAV 273 Query: 340 KDLSLNKLGIQTDDKGHIIV-DEFQNTNVKGIYAVGDVCGKALLTPV-AIAAGRKLA 394 SL + ++ G++ + T+V GI+A GDV V A G A Sbjct: 274 ---SLFEGKLKQKPNGYLWTAPDSTATDVPGIFAAGDVTDDIYRQAVTAAGMGCMAA 327 >3IWA-A nrPDB Length = 472 Score = 144 bits (364), Expect = 8e-35, Method: Composition-based stats. Identities = 76/367 (20%), Positives = 132/367 (35%), Gaps = 45/367 (12%) Query: 169 IIRGHAAFTSDPKPTIEVSG------KKYTAPHILIATGGMPSTPHES--QIPGASLGIT 220 ++ A T+E+ + +++A G + P + G + Sbjct: 84 LVETRAHAIDRAAHTVEIENLRTGERRTLKYDKLVLALGSKANRPPVEGMDLAGVTPVTN 143 Query: 221 SDGFFQLEEL-----PGRSVIVGAGYIAVEMAGILSAL-GSKTSLMIRHDKVLRSFDSM- 273 D ++ ++VIVG G+I +EMA L+ + G T+++ D+++ F S Sbjct: 144 LDEAEFVQHAISAGEVSKAVIVGGGFIGLEMAVSLADMWGIDTTVVELADQIMPGFTSKS 203 Query: 274 ISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAI 333 +S +LE V V +V ++ R+ D D ++ A Sbjct: 204 LSQMLRHDLEKNDVVVHTGEKVVRLEG---------ENGKVARVITDKRTLDADLVILAA 254 Query: 334 GRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGD-------VCGKALLTPV- 385 G PNT+ G++ D +G IIVD T+ I+A GD V GK P+ Sbjct: 255 GVSPNTQ--LARDAGLELDPRGAIIVDTRMRTSDPDIFAGGDCVTIPNLVTGKPGFFPLG 312 Query: 386 --AIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHK-YGIENVKT 442 A GR + L + + +F GLT + A+ + Y NV Sbjct: 313 SMANRQGRVIGTNLADGDATFPGAVGSWAVKLF-EGSASGAGLTVEGALREGYDAVNVHV 371 Query: 443 YSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHM---QGLGCDEMLQGFAVAVKMGA 499 ++ KT +++V +V+GI G + A + Sbjct: 372 EQFD-RAHFYP---EKTIMTLQLVVDRPTRRVLGIQGFSTLGDALTARINAVATMLASKP 427 Query: 500 TKADFDN 506 T D N Sbjct: 428 TVEDISN 434 >6BPY-A nrPDB Length = 374 Score = 141 bits (357), Expect = 5e-34, Method: Composition-based stats. Identities = 68/350 (19%), Positives = 111/350 (31%), Gaps = 51/350 (14%) Query: 61 AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS 120 + ++IG G +A + + + E GT A Sbjct: 1 GMVHTKVVIIGSGPAAHTAAIYLSRAELKPVLYEGMLANGT---------------AAGG 45 Query: 121 EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP 180 + FP + E R E+I + Sbjct: 46 QLTTTTDIENFPGFPDGIGGAELMENMRKQSIRF-----------GTEVITETISRVDLS 94 Query: 181 KPTIEVSGK---------KYTAPHILIATGGMPS---TPHESQI--PGASLGITSDGFFQ 226 ++ + TA ++IATG P E G S DG Sbjct: 95 SKPFKLWTEWNDGPDKEPACTADAVIIATGANARRLNLPGEETYWQNGISACAVCDGAVP 154 Query: 227 LEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAG 286 + ++G G A E A L+ GS ++++R DK LR+ +M L + Sbjct: 155 IFR-NKPLYVIGGGDSAAEEAMFLAKYGSSVTVLVRRDK-LRASKAMAKRL----LAHPK 208 Query: 287 VEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNK 346 V V + EV + + + I D + L +A+G P T +L K Sbjct: 209 VTVRFNTVATEVLGEKKPNGLMTHLRIKNTVTGEEEIVDANGLFYAVGHDPAT---ALVK 265 Query: 347 LGIQTDDKGHIIVDE-FQNTNVKGIYAVGDVCGKALL-TPVAIAAGRKLA 394 I D+ G+II T+ +G++A GDV K + +G A Sbjct: 266 GQIDLDEDGYIITKPGTSYTSREGVFACGDVQDKRYRQAITSAGSGCIAA 315 >5VJ7-A nrPDB Length = 476 Score = 141 bits (356), Expect = 7e-34, Method: Composition-based stats. Identities = 76/369 (20%), Positives = 123/369 (33%), Gaps = 82/369 (22%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVES-HKLGGTCVNVGCVPKKVMWNTAVHSEFMHD 125 +IG G GL A A++G + E+ H+ GG Sbjct: 157 VAIIGAGPAGLTCAADLAKMGYEVTIYEALHQPGGVLT---------------------- 194 Query: 126 HADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIE 185 YG P ++ L + + I G TI Sbjct: 195 ---YGIPEFRLP---------KEILRKEL-KKLSLLGVEIKTDHIVG---------KTIT 232 Query: 186 VSGKKYTAPHILIATGGMPSTPHESQIPGASL-GITSDGFFQLE-------ELPG----- 232 + + I TG TP IPG +L GI S F + P Sbjct: 233 IQELLQEYDAVFIGTGA--GTPKLPNIPGINLNGIYSANEFLTRINLMKAYKFPEYDTPI 290 Query: 233 ----RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVE 288 + V++GAG A++ A LG++ ++ R + D + E GV+ Sbjct: 291 VVGKKVVVIGAGNTAMDAARSALRLGAEVTIAYRRGR----EDMTARIEEVKHAEEEGVK 346 Query: 289 VLKFSQVKEVKKTLSGLEVSMVTAVPGRLPV-------------MTMIPDVDCLLWAIGR 335 + F E +G ++ L + + D ++ AIG+ Sbjct: 347 FMFFVNPVEFIGDENGNVKAVKFEKMKPLEERDSRGKRKIVGTGEYITVEADTVIIAIGQ 406 Query: 336 VPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAH 395 PN K L ++ D+ G I+VDE T++ G++A GD +A+ GRK A Sbjct: 407 TPN-KVLWRATPELKVDEWGRIVVDENLMTSIPGVFAGGDAIRGEATVILAMGDGRKAAK 465 Query: 396 RLFEYKEDS 404 + +Y Sbjct: 466 AIHQYLSKK 474 >1YQZ-A nrPDB Length = 438 Score = 140 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 64/359 (17%), Positives = 141/359 (39%), Gaps = 61/359 (16%) Query: 177 TSDPKPTIEV----SGKKYT--APHILIATGGMPSTPHESQIPGASLGITSDGFFQLEEL 230 +D + T+ V + +++ ++++ G + SLG SD F L L Sbjct: 84 INDERQTVSVLNRKTNEQFEESYDKLILSPGASAN----------SLGFESDITFTLRNL 133 Query: 231 PG--------------RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMIST 276 + ++VGAGY+++E+ L G +L+ R DK+ + D+ ++ Sbjct: 134 EDTDAIDQFIKANQVDKVLVVGAGYVSLEVLENLYERGLHPTLIHRSDKINKLMDADMNQ 193 Query: 277 NCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRV 336 +EL+ + ++ + +G E++ + + D ++ +G Sbjct: 194 PILDELDKREIPYRLNEEINAI----NGNEITFKSGK---------VEHYDMIIEGVGTH 240 Query: 337 PNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDV-------CGKALLTPVAIAA 389 PN+K + I+ D KG I V++ TNV IYA+GD+ P+A A Sbjct: 241 PNSKFI--ESSNIKLDRKGFIPVNDKFETNVPNIYAIGDIATSHYRHVDLPASVPLAWGA 298 Query: 390 GRKLAHRLFEYKEDSKLDYNNIPT---VVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTS 446 R + + + +++ V F +VG+ +E + ++ + V+ + Sbjct: 299 HRAASIVAEQIAGNDTIEFKGFLGNNIVKFFDYTFASVGVKPNE-LKQFDYKMVEVTQGA 357 Query: 447 FTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQG-LGCDEMLQGFAVAVKMGATKADF 504 Y+ + +++ +++ G G D+ + ++A+ T + Sbjct: 358 -HANYYP---GNSPLHLRVYYDTSNRQILRAAAVGKEGADKRIDVLSMAMMNQLTVDEL 412 >3AB1-A nrPDB Length = 360 Score = 138 bits (348), Expect = 5e-33, Method: Composition-based stats. Identities = 70/357 (19%), Positives = 126/357 (35%), Gaps = 42/357 (11%) Query: 57 PAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVNVGCVPKKVMWN 115 PA D +IGGG G+ +A + ++ES +LGG P+K +++ Sbjct: 7 PATDHHDMRDLTIIGGGPTGIFAAFQCGMNNISCRIIESMPQLGGQLA--ALYPEKHIYD 64 Query: 116 TAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAA 175 A GFP + + + Y N N E + + Sbjct: 65 VA------------GFPEVPAIDLVESLWAQAERY----NPDVVLN------ETVTKYTK 102 Query: 176 FTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGIT-SDGFFQLEELP--- 231 T +G Y + +LIA G P + G +T S ++ ++ + Sbjct: 103 LDDGTFETRTNTGNVYRSRAVLIAAGLGAFEPRKLPQLGNIDHLTGSSVYYAVKSVEDFK 162 Query: 232 -GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVL 290 R VIVG G A++ L + +L+ R + + N ++V Sbjct: 163 GKRVVIVGGGDSALDWTVGLIKNAASVTLVHRGHEF--QGHGKTAHEVERARANGTIDVY 220 Query: 291 KFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQ 350 ++V ++++ L + + G + D LL IG N L+ L + Sbjct: 221 LETEVASIEESNGVLTRVHLRSSDGS----KWTVEADRLLILIGFKSNLGPLARWDLELY 276 Query: 351 TDDKGHIIVDEFQNTNVKGIYAVGDVC---GKALLTPVAIAAGRKLAHRLFEYKEDS 404 + ++VD T+V G+YA GD+ GK + ++ Y + Sbjct: 277 EN---ALVVDSHMKTSVDGLYAAGDIAYYPGKLKIIQTGLSEATMAVRHSLSYIKPG 330 >2ZBW-A nrPDB Length = 335 Score = 137 bits (346), Expect = 9e-33, Method: Composition-based stats. Identities = 74/336 (22%), Positives = 120/336 (35%), Gaps = 50/336 (14%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 D L++G G GL + G V+ + GG P+K +++ A Sbjct: 7 DVLIVGAGPTGLFAGFYVGMRGLSFRFVDPLPEPGGQLT--ALYPEKYIYDVA------- 57 Query: 125 DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTI 184 GFP K + + E+ V+ N +Y +E D Sbjct: 58 -----GFPKVYAKDLVKGLVEQ----VAPFNPVYSLGERAETLER-------EGDLFKVT 101 Query: 185 EVSGKKYTAPHILIATGGMPSTPHESQIPGAS--------LGITSDGFFQLEELPGRSVI 236 G YTA ++IA G P PG + S FQ R +I Sbjct: 102 TSQGNAYTAKAVIIAAGVGAFEPRRIGAPGEREFEGRGVYYAVKSKAEFQ----GKRVLI 157 Query: 237 VGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVK 296 VG G AV+ A L + +L+ R + R+ ++ + + E +EVL +++ Sbjct: 158 VGGGDSAVDWALNLLDTARRITLIHRRPQF-RAHEASV-KELMKAHEEGRLEVLTPYELR 215 Query: 297 EVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGH 356 V+ + + +VD +L G + TK L G+ +K Sbjct: 216 RVEGDERVRWAVVFHNQTQEE----LALEVDAVLILAGYI--TKLGPLANWGLAL-EKNK 268 Query: 357 IIVDEFQNTNVKGIYAVGDVC---GKALLTPVAIAA 389 I VD T++ G+YA GD+ GK L + Sbjct: 269 IKVDTTMATSIPGVYACGDIVTYPGKLPLIVLGFGE 304 >6GAR-A nrPDB Length = 349 Score = 137 bits (345), Expect = 1e-32, Method: Composition-based stats. Identities = 72/358 (20%), Positives = 143/358 (39%), Gaps = 42/358 (11%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKKVMWNTAVHSEFM 123 +D VIGGG GL SA + R ++E H LGG + P+K++W+ Sbjct: 7 FDVTVIGGGPAGLYSAFYSGLREMRTKIIEFHPHLGG---KIHVYPEKMIWDVG------ 57 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 G G + ++ L + L + +E I D T Sbjct: 58 ------GLLPVTGDKLIEQLVQQ------GLTFKPEVVL-DTKVESII----RNQDGTFT 100 Query: 184 IEVS-GKKYTAPHILIATGGMPSTPHESQIPGASLGITSD---GFFQLEELPGRSVIV-G 238 ++ S G+++ + +++ATG P + I GA S+ L+ G++VI+ G Sbjct: 101 LKTSTGEEHFSKTVIVATGSGILKPQKLSIEGAERFEVSNLNYTVKSLKRFKGKTVIISG 160 Query: 239 AGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEV 298 G AV+ A L + K + R ++ L ++ + ++L N+ E + + ++ Sbjct: 161 GGNSAVDWANELEPIAKKVYVTYRKEE-LSGHEAQV-----KQLMNSSAECFFNTSITKL 214 Query: 299 KKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHII 358 + + V ++ +P +D ++ G + L ++L + D +I Sbjct: 215 IAGDNHEAIEYVELTNHETGEVSHLP-IDEVIINHGYERDITLLENSELDVAIIDNYYIA 273 Query: 359 VDEFQNTNVKGIYAVGDVC---GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPT 413 + ++V G+YA GD+ GK L A ++ ++ + +Y + + Sbjct: 274 GNANSESSVDGLYAAGDILKHEGKLHLIAGAFQDAGNAVNKAKQFIQPDASEYGMVSS 331 >1VDC-A nrPDB Length = 333 Score = 135 bits (340), Expect = 5e-32, Method: Composition-based stats. Identities = 55/267 (20%), Positives = 89/267 (33%), Gaps = 29/267 (10%) Query: 153 RLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIE--VSGKKYTAPHILIATGGMPSTPHES 210 L ++ + I + K A +++A G + Sbjct: 71 ELTDKFRKQSERFGTTIFTETVTKVDFSSKPFKLFTDSKAILADAVILAIGAVAKRLSFV 130 Query: 211 Q---------IPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMI 261 G S DG + ++G G A+E A L+ GSK ++ Sbjct: 131 GSGEVLGGFWNRGISACAVCDGAAPIFR-NKPLAVIGGGDSAMEEANFLTKYGSKVYIIH 189 Query: 262 RHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGL---EVSMVTAVPGRLP 318 R D R+ M L N ++V+ S V E + + V G + Sbjct: 190 RRD-AFRASKIM----QQRALSNPKIDVIWNSSVVEAYGDGERDVLGGLKVKNVVTGDVS 244 Query: 319 VMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDE-FQNTNVKGIYAVGDVC 377 + V L +AIG P TK L G++ D G+++ T+V G++A GDV Sbjct: 245 DLK----VSGLFFAIGHEPATKFL---DGGVELDSDGYVVTKPGTTQTSVPGVFAAGDVQ 297 Query: 378 GKALL-TPVAIAAGRKLAHRLFEYKED 403 K A G A Y ++ Sbjct: 298 DKKYRQAITAAGTGCMAALDAEHYLQE 324 >5M5J-A nrPDB Length = 325 Score = 131 bits (329), Expect = 9e-31, Method: Composition-based stats. Identities = 69/331 (20%), Positives = 112/331 (33%), Gaps = 53/331 (16%) Query: 74 SGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPS 133 GL + A+ + TCV VG M+ T F A G Sbjct: 27 PAGLTAGIYASRANLK-----------TCVFVGIEHTSQMFTTTDVENFPSHTAIKG--- 72 Query: 134 CEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEV-SGKKYT 192 + E A L + I +S P + + Sbjct: 73 -------PALMEAIQNQAEHCGA----ELLYEDVHSID----VSSRPFKIVHGYENETTL 117 Query: 193 APHILIATGGMPST-----PHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMA 247 A ++IATG E G S D + +A E A Sbjct: 118 ADALIIATGATARRLDCKGEKEYWQKGVSACAVCDSAMATGKEVVVVGGG---DVACEEA 174 Query: 248 GILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLE- 306 L+ + +K +++R DK S + + + +E++ S + E+K + Sbjct: 175 TYLTKIATKVYMVLRRDKFRAS-----AAMVKKVMNEKLIEIIYDSAIDEIKGDGKCVTS 229 Query: 307 VSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEF--QN 364 VS+ G+ T + L WA+G P T L K ++ D+ G+I++ + Q Sbjct: 230 VSIKNLKDGK----TRTLNAGALYWAVGHDPQTSFLK--KGQLEQDEAGYILLKDHPTQR 283 Query: 365 TNVKGIYAVGDVCGKALLTP-VAIAAGRKLA 394 T+V G++A GD C VA +G K A Sbjct: 284 TSVDGVFAAGDCCDHLYRQAVVAAGSGSKAA 314 >3OC4-A nrPDB Length = 452 Score = 128 bits (322), Expect = 6e-30, Method: Composition-based stats. Identities = 76/460 (16%), Positives = 147/460 (31%), Gaps = 73/460 (15%) Query: 67 YLVIGGGSGGLASARRAAEL--GARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 ++IG G+++A + + A ++++ S + Sbjct: 5 IVIIGASFAGISAAIASRKKYPQAEISLIDKQA-----------------TVGYLSGGLS 47 Query: 125 DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTI 184 + ++ + E R L L + + T Sbjct: 48 AYFNHTI---------NELHEARYITEEELRRQKIQLLLNREVVAMDVENQLI---AWTR 95 Query: 185 EVSGKKYTAPHILIATGGMPSTPHESQIPGASL-----GITSDGFFQ---LEELPGRSVI 236 + + Y+ +++ATG +QI G+ G L E + Sbjct: 96 KEEQQWYSYDKLILATGASQF---STQIRGSQTEKLLKYKFLSGALAAVPLLENSQTVAV 152 Query: 237 VGAGYIAVEMAGILSALGSKTSLMIRHDKVLR-SFDSMISTNCTEELENAGVEVLKFSQV 295 +GAG I +E L + + + +L FD + + LE V V Sbjct: 153 IGAGPIGMEAIDFLVKMKKTVHVFESLENLLPKYFDKEMVAEVQKSLEKQAVIFHFEETV 212 Query: 296 KEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKG 355 +++T +G+ L D ++A+ P L IQ + Sbjct: 213 LGIEETANGI----------VLETSEQEISCDSGIFALNLHPQLAYL---DKKIQRNLDQ 259 Query: 356 HIIVDEFQNTNVKGIYAVGDV----------CGKALLTPVAIAAGRKLAHRLFEYKEDSK 405 I VD + T+V ++A+GD A L A+ G +A+ L E Sbjct: 260 TIAVDAYLQTSVPNVFAIGDCISVMNEPVAETFYAPLVNNAVRTGLVVANNLEEKTHRFI 319 Query: 406 LDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKM 465 + T V + + GLTE E + P+ + T+ + K+ Sbjct: 320 GSLRTMGTKV-GDYYLASTGLTETEGLFFPQTLASIIVRQPAPPL-----QHGTEILGKL 373 Query: 466 VCANKEEKVVGIHMQGL-GCDEMLQGFAVAVKMGATKADF 504 + ++V+G + C E + A++++ G T D Sbjct: 374 IYDKVTQRVLGAQLCSKNNCLEKINTLALSIQTGQTLTDL 413 >2WHD-A nrPDB Length = 351 Score = 126 bits (318), Expect = 2e-29, Method: Composition-based stats. Identities = 65/347 (18%), Positives = 115/347 (33%), Gaps = 47/347 (13%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDH 126 +IG G +A AA + + E N + + Sbjct: 33 VCIIGSGPAAHTAAIYAARAELKPVLFEGW-----MAND-------IAAGGQLTTTTDVE 80 Query: 127 ADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEV 186 GFP+ + + R V + N+ + + A + Sbjct: 81 NFPGFPTGIMGIDL--MDNCRAQSVR-----FGTNILSETVTEVDFSAR-----PFRVTS 128 Query: 187 SGKKYTAPHILIATGGMPSTPHESQ-----IPGASLGITSDGFFQLEELPGRSVIVGAGY 241 A +++ATG + + S G S DG + ++G G Sbjct: 129 DSTTVLADTVVVATGAVARRLYFSGSDTYWNRGISACAVCDGAAPIFR-NKPIAVIGGGD 187 Query: 242 IAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKE---V 298 A+E L+ GS+ ++ R + R+ M + L N ++V+ S+V E Sbjct: 188 SAMEEGNFLTKYGSQVYIIHRRN-TFRASKIMQA----RALSNPKIQVVWDSEVVEAYGG 242 Query: 299 KKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHII 358 V + V G + V L +AIG P TK L+ ++ G++ Sbjct: 243 AGGGPLAGVKVKNLVTGEVSD----LQVSGLFFAIGHEPATKFLN---GQLELHADGYVA 295 Query: 359 VDE-FQNTNVKGIYAVGDVCGKALL-TPVAIAAGRKLAHRLFEYKED 403 +T+V+G++A GDV K A +G A Y ++ Sbjct: 296 TKPGSTHTSVEGVFAAGDVQDKKYRQAITAAGSGCMAALDAEHYLQE 342 >5XHU-A nrPDB Length = 329 Score = 126 bits (317), Expect = 2e-29, Method: Composition-based stats. Identities = 65/349 (18%), Positives = 129/349 (36%), Gaps = 46/349 (13%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVNVGCVPKKVMWNTAVHSEFM 123 YD +IGGG GL +A + V+E KLGG P+K++ + Sbjct: 3 YDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGGKVSLF--FPEKIIRDIG------ 54 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 G P GK +KE+ + + + + G Sbjct: 55 ------GIPGIAGKQLIEQLKEQAATFDPDIVLN----------QRVTGFERLDDGTIVL 98 Query: 184 IEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSD---GFFQLEELPGRSVIV-GA 239 GKK+ +++A G +E A+ + G +L+ G+ V++ G Sbjct: 99 TGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVISGG 158 Query: 240 GYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVK 299 G AV+ A L + + +++ R ++ +S ++ ++ + V VL +++++ Sbjct: 159 GDTAVDWANELEPIAASVTVVHRREEF-GGMESSVTK-----MKQSSVRVLTPYRLEQLN 212 Query: 300 KTLSGLE-VSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHII 358 G++ V++ G+ + ++D L+ G + + L I ++G + Sbjct: 213 GDEEGIKSVTVCHTESGQRKDI----EIDELIINHGFKIDLGPMMEWGLEI---EEGRVK 265 Query: 359 VDEFQNTNVKGIYAVGDVCG---KALLTPVAIAAGRKLAHRLFEYKEDS 404 D TN+ G++ GD K L G + Y + Sbjct: 266 ADRHMRTNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPK 314 >1Q1R-A nrPDB Length = 431 Score = 125 bits (314), Expect = 5e-29, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 107/295 (36%), Gaps = 51/295 (17%) Query: 160 NNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGI 219 L + + I D + I G+ +++ATGG P +P AS + Sbjct: 76 QLLGGTQVTAIN------RDRQQVILSDGRALDYDRLVLATGGRPR-----PLPVASGAV 124 Query: 220 -TSDGFFQLEELPG------------RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKV 266 ++ F L L R V++G GYI +E+A +L+ +V Sbjct: 125 GKANNFRYLRTLEDAECIRRQLIADNRLVVIGGGYIGLEVAATAIKANMHVTLLDTAARV 184 Query: 267 LRSFDSMISTNCTEELE-NAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPD 325 L + + E L AGV++ +QV + + +V+ V G Sbjct: 185 LERVTAPPVSAFYEHLHREAGVDIRTGTQVCGFEMSTDQQKVTAVLCEDGTR------LP 238 Query: 326 VDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCG------- 378 D ++ IG +PN + S G+Q D I+++E T+ I AVGD Sbjct: 239 ADLVIAGIGLIPNCELASA--AGLQVD--NGIVINEHMQTSDPLIMAVGDCARFHSQLYD 294 Query: 379 ---KALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIG--TVGLTE 428 + P A+ RK+A L P IG VGL+E Sbjct: 295 RWVRIESVPNALEQARKIAAILCGKVPRD----EAAPWFWSDQYEIGLKMVGLSE 345 Score = 31.1 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 24/130 (18%), Positives = 46/130 (35%), Gaps = 26/130 (20%) Query: 234 SVIVGAGYIAVEMAGILSALGSKTSLMIRHD------KVLRSFDSMISTNCT-------- 279 VIVG G VE+A L A G + ++ + D + + ++ T Sbjct: 7 VVIVGTGLAGVEVAFGLRASGWEGNIRLVGDATVIPHHLPPLSKAYLAGKATAESLYLRT 66 Query: 280 -EELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPN 338 + +++L +QV + + + +S D D L+ A G P Sbjct: 67 PDAYAAQNIQLLGGTQVTAINRDRQQVILS-----------DGRALDYDRLVLATGGRPR 115 Query: 339 TKDLSLNKLG 348 ++ +G Sbjct: 116 PLPVASGAVG 125 Score = 29.5 bits (65), Expect = 4.1, Method: Composition-based stats. Identities = 9/28 (32%), Positives = 14/28 (50%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVE 94 +VIGGG GL A A + +++ Sbjct: 152 LVVIGGGYIGLEVAATAIKANMHVTLLD 179 >5JCN-A nrPDB Length = 451 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 51/209 (24%), Positives = 85/209 (40%), Gaps = 30/209 (14%) Query: 188 GKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELP--------------GR 233 G +T ++IATG + GA S+ L E+ G+ Sbjct: 127 GATFTYEILIIATGSSVIKLSDFGTQGA----DSNNILYLREVDDADKLVAAIQAKKGGK 182 Query: 234 SVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVL-RSFDSMISTNCTEELENAGVEVLKF 292 +VIVG GYI +E++ L +++ + R F + I+ N GV+++K Sbjct: 183 AVIVGGGYIGLELSAALKINDFDVTMVFPEPWCMPRLFTADIAAFYESYYTNKGVKIVKG 242 Query: 293 SQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD 352 + +G +V+ V G + + D ++ +G P T G + Sbjct: 243 TVAVGFDADANG-DVTAVNLKNGS------VLEADIVVVGVGGRPLTTLFK----GQVAE 291 Query: 353 DKGHIIVDEFQNTNVKGIYAVGDVCGKAL 381 +KG I D F T+V G+YAVGDV + Sbjct: 292 EKGGIKTDAFFETSVPGVYAVGDVATFPM 320 Score = 35.7 bits (81), Expect = 0.050, Method: Composition-based stats. Identities = 28/173 (16%), Positives = 55/173 (31%), Gaps = 33/173 (19%) Query: 77 LASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEG 136 L +A +A + G +A +V +G + A + Sbjct: 171 LVAAIQAKK-GGKAVIVGGGYIG-----------------------LELSAALKINDFDV 206 Query: 137 KFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAA--FTSDPKPTIEV----SGKK 190 + + + + A Y++ T ++I++G A F +D + +G Sbjct: 207 TMVFPEPWCMPRLFTADIAAFYESYYTNKGVKIVKGTVAVGFDADANGDVTAVNLKNGSV 266 Query: 191 YTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIA 243 A +++ GG P T G F +PG + G +A Sbjct: 267 LEADIVVVGVGGRPLTTLFKGQVAEEKGGIKTDAFFETSVPGVYAV---GDVA 316 >4YKF-A nrPDB Length = 521 Score = 120 bits (301), Expect = 2e-27, Method: Composition-based stats. Identities = 77/350 (22%), Positives = 131/350 (37%), Gaps = 48/350 (13%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFM 123 +YD L++G G G A+A +A G R ++ + GG ++ Sbjct: 212 AYDVLIVGSGPAGAAAAIYSARKGIRTGLM-GERFGGQILD------------------T 252 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 D +Y K + + +V + ++ + S + A Sbjct: 253 VDIENY---ISVPKTEGQKLAGALKVHVDEYDVDVIDSQSASKL-----IPAAVEGGLHQ 304 Query: 184 IEV-SGKKYTAPHILIATGGMPS---TPHESQI--PGASLGITSDGFFQLEELPGRSVIV 237 IE SG A I++ATG P E Q G + DG R ++ Sbjct: 305 IETASGAVLKARSIIVATGAKWRNMNVPGEDQYRTKGVTYCPHCDGPLFKG---KRVAVI 361 Query: 238 GAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKE 297 G G VE A L+ + +L+ ++ D ++ L+N V+++ +Q E Sbjct: 362 GGGNSGVEAAIDLAGIVEHVTLLEFAPEM--KADQVLQDKL-RSLKN--VDIILNAQTTE 416 Query: 298 VKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHI 357 VK G +V + R+ ++ + IG +PNT L ++ + G I Sbjct: 417 VKG--DGSKVVGLEYRD-RVSGDIHNIELAGIFVQIGLLPNTNWLE---GAVERNRMGEI 470 Query: 358 IVDEFQNTNVKGIYAVGDVCGKAL-LTPVAIAAGRKLAHRLFEYKEDSKL 406 I+D TNVKG++A GD +A G K + F+Y +K Sbjct: 471 IIDAKCETNVKGVFAAGDCTTVPYKQIIIATGEGAKASLSAFDYLIRTKT 520 >1FL2-A nrPDB Length = 310 Score = 115 bits (289), Expect = 4e-26, Method: Composition-based stats. Identities = 77/350 (22%), Positives = 131/350 (37%), Gaps = 48/350 (13%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFM 123 +YD L++G G G A+A +A G R ++ + GG ++ Sbjct: 1 AYDVLIVGSGPAGAAAAIYSARKGIRTGLM-GERFGGQILD------------------T 41 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 D +Y K + + +V + ++ + S + A Sbjct: 42 VDIENY---ISVPKTEGQKLAGALKVHVDEYDVDVIDSQSASKL-----IPAAVEGGLHQ 93 Query: 184 IEV-SGKKYTAPHILIATGGMPS---TPHESQI--PGASLGITSDGFFQLEELPGRSVIV 237 IE SG A I++ATG P E Q G + DG R ++ Sbjct: 94 IETASGAVLKARSIIVATGAKWRNMNVPGEDQYRTKGVTYCPHCDGPLFKG---KRVAVI 150 Query: 238 GAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKE 297 G G VE A L+ + +L+ ++ D ++ L+N V+++ +Q E Sbjct: 151 GGGNSGVEAAIDLAGIVEHVTLLEFAPEM--KADQVLQDKL-RSLKN--VDIILNAQTTE 205 Query: 298 VKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHI 357 VK G +V + R+ ++ + IG +PNT L ++ + G I Sbjct: 206 VKG--DGSKVVGLEYRD-RVSGDIHNIELAGIFVQIGLLPNTNWLE---GAVERNRMGEI 259 Query: 358 IVDEFQNTNVKGIYAVGDVCGKAL-LTPVAIAAGRKLAHRLFEYKEDSKL 406 I+D TNVKG++A GD +A G K + F+Y +K Sbjct: 260 IIDAKCETNVKGVFAAGDCTTVPYKQIIIATGEGAKASLSAFDYLIRTKT 309 >5TWC-A nrPDB Length = 344 Score = 111 bits (277), Expect = 1e-24, Method: Composition-based stats. Identities = 58/347 (16%), Positives = 120/347 (34%), Gaps = 42/347 (12%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 D +IGGG GL ++ A +++ +LGG P+K++W+ + Sbjct: 3 DVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKM---RIYPEKIIWDIGGIAPKPC 59 Query: 125 DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTI 184 +D L + +L + ++I ++ + Sbjct: 60 HEIL------------------KDTIKQGLYFKPEVHLNERVVDI-----RKKAERHFEV 96 Query: 185 EVS-GKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELP----GRSVIVGA 239 E G+ YT+ ++IA G P + + G ++ + ++ +I G Sbjct: 97 ETEAGEIYTSKAVIIAIGAGIINPKQLDVKGVERYQLTNLHYVVQSYRRFKDKDVLISGG 156 Query: 240 GYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVK 299 G A++ A ++ + +++ R + V S + T T+ V++ +++K + Sbjct: 157 GNTALDWAHDIAKIAKSVTVVYRKEDV--SGHEAMKTLVTD----LNVKLCPKTRIKYLV 210 Query: 300 KTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIV 359 +S V D ++ + G LS + D + Sbjct: 211 GNDDETHISEVVLEH-VESGDRHTVKFDDVIISHGFDRCNTLLSETSSKLDMHDDCRVKG 269 Query: 360 DEFQNTNVKGIYAVGDVCGKAL---LTPVAIAAGRKLAHRLFEYKED 403 T++ GIYA GD+ L A + G A+ Y + Sbjct: 270 FGNTTTSIPGIYACGDIVYHDAKSHLIASAFSDGANAANLAKTYIQP 316 >3LXD-A nrPDB Length = 415 Score = 110 bits (275), Expect = 2e-24, Method: Composition-based stats. Identities = 50/252 (19%), Positives = 94/252 (37%), Gaps = 27/252 (10%) Query: 177 TSDPKPTIEV-SGKKYTAPHILIATGGMPSTPH--ESQIPGASLGITSDGF----FQLEE 229 T+++ G ++ ATGG P + + G T + +L+ Sbjct: 91 LDPAAHTVKLGDGSAIEYGKLIWATGGDPRRLSCVGADLAGVHAVRTKEDADRLMAELDA 150 Query: 230 LPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVL-RSFDSMISTNCTEELENAGVE 288 +V++G GYI +E A +L+ G +L+ +VL R +S E GV+ Sbjct: 151 GAKNAVVIGGGYIGLEAAAVLTKFGVNVTLLEALPRVLARVAGEALSEFYQAEHRAHGVD 210 Query: 289 VLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLG 348 + + + ++ G +V+ V G + D ++ IG VP L Sbjct: 211 LRTGAAMDCIEG--DGTKVTGVRMQDGS------VIPADIVIVGIGIVPCVGALISAGA- 261 Query: 349 IQTDDKGHIIVDEFQNTNVKGIYAVGDV-------CGKALLTPVAIAAGRKLAHRLFEYK 401 + VDEF T++ +YA+GD A++ ++ +A + Sbjct: 262 ---SGGNGVDVDEFCRTSLTDVYAIGDCAAHANDFADGAVIRLESVQNANDMATAAAKDI 318 Query: 402 EDSKLDYNNIPT 413 + + Y P Sbjct: 319 CGAPVPYKATPW 330 >1XHC-A nrPDB Length = 367 Score = 108 bits (270), Expect = 6e-24, Method: Composition-based stats. Identities = 82/392 (20%), Positives = 139/392 (35%), Gaps = 78/392 (19%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVP--KKVMWNTAVHSEFMH 124 +++G G GG A++ ++ V++ VP K M + H Sbjct: 11 VVIVGNGPGGFELAKQLSQ-TYEVTVIDKEP----------VPYYSKPMLS---HYIAGF 56 Query: 125 DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEI-IRGHAAFTSDPKPT 183 + FP +W K IEI + A + Sbjct: 57 IPRNRLFPYS---LDW---------------------YRKRGIEIRLAEEAKLIDRGRKV 92 Query: 184 IEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVG----- 238 + + +++ATG P QI G +T F + + G Sbjct: 93 VITEKGEVPYDTLVLATGARAREP---QIKGKEYLLTLRTIFDADRIKESIENSGEAIII 149 Query: 239 -AGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKE 297 G+I +E+AG L+ G L+ R L D +S + LE GV+ S++ Sbjct: 150 GGGFIGLELAGNLAEAGYHVKLIHRGAMFL-GLDEELSNMIKDMLEETGVKFFLNSEL-- 206 Query: 298 VKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHI 357 ++ G+ ++ + G++ + AIG VPN + GI T I Sbjct: 207 LEANEEGV-LTNSGFIEGKVK-----------ICAIGIVPNVD--LARRSGIHTGRG--I 250 Query: 358 IVDEFQNTNVKGIYAVGDVCGK----ALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPT 413 ++D+ T+ K +YA+GD A A+ R LA L E + ++ T Sbjct: 251 LIDDNFRTSAKDVYAIGDCAEYSGIIAGTAKAAMEQARVLADIL--KGEPRRYNFKFRST 308 Query: 414 V-VFSHPPIGTVGLTEDEAIHKYGIENVKTYS 444 V F I +G T+ E K+ +N K + Sbjct: 309 VFKFGKLQIAIIGNTKGEG--KWIEDNTKVFY 338 Score = 29.5 bits (65), Expect = 3.6, Method: Composition-based stats. Identities = 24/125 (19%), Positives = 41/125 (32%), Gaps = 30/125 (24%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCT------------- 279 + VIVG G E+A LS + +++ + M+S Sbjct: 10 KVVIVGNGPGGFELAKQLSQT-YEVTVIDKEPVPY-YSKPMLSHYIAGFIPRNRLFPYSL 67 Query: 280 EELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIG---RV 336 + G+E+ + K + + +V G +P D L+ A G R Sbjct: 68 DWYRKRGIEIRLAEEAKLIDR-----GRKVVITEKGEVP-------YDTLVLATGARARE 115 Query: 337 PNTKD 341 P K Sbjct: 116 PQIKG 120 >3FG2-P nrPDB Length = 404 Score = 102 bits (254), Expect = 4e-22, Method: Composition-based stats. Identities = 55/272 (20%), Positives = 95/272 (34%), Gaps = 33/272 (12%) Query: 159 QNNLTKSHIEIIRGHAAFTS-DPKPTIEVSGKKYTAPHILIATGGMPSTPHESQ--IPGA 215 + IE+I + + + SG H+++ATG +P Sbjct: 64 EKFFQDQAIELISDRMVSIDREGRKLLLASGTAIEYGHLVLATGARNRMLDVPNASLPDV 123 Query: 216 SLGITSDGFFQLEE-LP--GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVL-RSFD 271 T D L + +P V++GAG+I +E A A G + ++ +V+ R Sbjct: 124 LYLRTLDESEVLRQRMPDKKHVVVIGAGFIGLEFAATARAKGLEVDVVELAPRVMARVVT 183 Query: 272 SMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLW 331 IS+ + AG+ + + E+ G V+ V G D ++ Sbjct: 184 PEISSYFHDRHSGAGIRMHYGVRATEI--AAEGDRVTGVVLSDGN------TLPCDLVVV 235 Query: 332 AIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDV----------CGKAL 381 +G +PN + + L IIVD+ T+ I A+GD + Sbjct: 236 GVGVIPNVEIAAAAGLPTAAG----IIVDQQLLTSDPHISAIGDCALFESVRFGETMRVE 291 Query: 382 LTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPT 413 A R +A RL + Y+ P Sbjct: 292 SVQNATDQARCVAARLTGDAKP----YDGYPW 319 Score = 28.7 bits (63), Expect = 6.7, Method: Composition-based stats. Identities = 12/28 (42%), Positives = 13/28 (46%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVE 94 +VIG G GL A A G VVE Sbjct: 145 VVVIGAGFIGLEFAATARAKGLEVDVVE 172 >2V3B-A nrPDB Length = 384 Score = 98.1 bits (243), Expect = 8e-21, Method: Composition-based stats. Identities = 80/430 (18%), Positives = 135/430 (31%), Gaps = 75/430 (17%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDH 126 ++IG G G AR +L + +M + Sbjct: 7 LVIIGTGLAGYNLAREWRKLDGETPL-------------------LMITADDGRSYSKPM 47 Query: 127 ADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEV 186 GF + + A +LNA LT + + I I + Sbjct: 48 LSTGFSKNKDADGLA--MAEPGAMAEQLNA---RILTHTRVTGI-------DPGHQRIWI 95 Query: 187 SGKKYTAPHILIATGGMP-STPHESQIPGASLGI----TSDGFFQLEELPGRSVIVGAGY 241 ++ +++A G P P E A I F Q R +++GAG Sbjct: 96 GEEEVRYRDLVLAWGAEPIRVPVEGDAQDALYPINDLEDYARFRQAAAGKRRVLLLGAGL 155 Query: 242 IAVEMAGILSALGSKTSLMIRHDKVLRS-FDSMISTNCTEELENAGVEVLKFSQVKEVKK 300 I E A LS+ G + ++ ++V+ + LE GV + +KK Sbjct: 156 IGCEFANDLSSGGYQLDVVAPCEQVMPGLLHPAAAKAVQAGLEGLGVRFHLGPVLASLKK 215 Query: 301 TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD 360 GLE + + D ++ A+G P T+ G+ + I+VD Sbjct: 216 AGEGLEAHLSDGE---------VIPCDLVVSAVGLRPRTE--LAFAAGLAVNRG--IVVD 262 Query: 361 EFQNTNVKGIYAVGDV--CGKALLTPVA--IAAGRKLAHRLFEYKEDSKLDYNNIPTVVF 416 T+ IYA+GD L V +A R LA L ++ Y +P V Sbjct: 263 RSLRTSHANIYALGDCAEVDGLNLLYVMPLMACARALAQTLAGNPS--QVAYGPMPVTVK 320 Query: 417 SHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVG 476 + S M + +K++C + +V+G Sbjct: 321 TP-------------------ACPLVVSPPPRGMDGQWLVEGSGTDLKVLCRDTAGRVIG 361 Query: 477 IHMQGLGCDE 486 + G +E Sbjct: 362 YALTGAAVNE 371 >2VDC-G nrPDB Length = 456 Score = 95.4 bits (236), Expect = 6e-20, Method: Composition-based stats. Identities = 36/191 (18%), Positives = 66/191 (34%), Gaps = 19/191 (9%) Query: 226 QLEELPGRSVIVGAGYIAVEMAGILSALGS-KTSLMIRHDKV-LRSFDSMISTNCTEELE 283 L V++G G A++ G+ + R D+ + ++ E Sbjct: 259 SLNAAGKHVVVLGGGDTAMDCVRTAIRQGATSVKCLYRRDRKNMPGSQREVA-----HAE 313 Query: 284 NAGVEVLKFSQVKEVKKTLSGLEVSMVT-----------AVPGRLPVMTMIPDVDCLLWA 332 GVE + + + V V P + D ++ A Sbjct: 314 EEGVEFIWQAAPEGFTGDTVVTGVRAVRIHLGVADATGRQTPQVIEGSEFTVQADLVIKA 373 Query: 333 IGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQN-TNVKGIYAVGDVCGKALLTPVAIAAGR 391 +G P + ++ ++ G ++VD TN+ G++A GD+ A L AI GR Sbjct: 374 LGFEPEDLPNAFDEPELKVTRWGTLLVDHRTKMTNMDGVFAAGDIVRGASLVVWAIRDGR 433 Query: 392 KLAHRLFEYKE 402 A + Y + Sbjct: 434 DAAEGIHAYAK 444 >2YVG-A nrPDB Length = 408 Score = 89.6 bits (221), Expect = 3e-18, Method: Composition-based stats. Identities = 45/222 (20%), Positives = 85/222 (38%), Gaps = 25/222 (11%) Query: 166 HIEIIRG-HAAFTSDPKPTIEV-SGKKYTAPHILIATGGMPSTPHESQIPGASLGI--TS 221 +E + G A T+ + G+ +++ATG P Q + T Sbjct: 73 EVEWLLGVTAQSFDPQAHTVALSDGRTLPYGTLVLATGAAPRALPTLQGATMPVHTLRTL 132 Query: 222 DGFFQLE---ELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVL-RSFDSMISTN 277 + +++ R +IVG G I +E+A G SL+ +++ R+ + ++ Sbjct: 133 EDARRIQAGLRPQSRLLIVGGGVIGLELAATARTAGVHVSLVETQPRLMSRAAPATLADF 192 Query: 278 CTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVP 337 GV++ +++++G +V G D ++ IG + Sbjct: 193 VARYHAAQGVDLR-------FERSVTGSVDGVVLLDDGTR------IAADMVVVGIGVLA 239 Query: 338 NTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGK 379 N D G+ DD I VD + T +YA+GDV + Sbjct: 240 N--DALARAAGLACDDG--IFVDAYGRTTCPDVYALGDVTRQ 277 Score = 28.4 bits (62), Expect = 7.6, Method: Composition-based stats. Identities = 11/30 (36%), Positives = 16/30 (53%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESH 96 L++GGG GL A A G ++VE+ Sbjct: 148 LLIVGGGVIGLELAATARTAGVHVSLVETQ 177 >4EMJ-A nrPDB Length = 410 Score = 86.5 bits (213), Expect = 3e-17, Method: Composition-based stats. Identities = 55/214 (25%), Positives = 76/214 (35%), Gaps = 20/214 (9%) Query: 177 TSDPKPTIEVS-GKKYTAPHILIATGGMPST--PHESQIPGASLGITSDGFFQLEEL--- 230 TI + G +A I+IATG T SQ+PG T L + Sbjct: 83 LDVQTRTISLDDGTTLSADAIVIATGSRARTMALPGSQLPGVVTLRTYGDVQVLRDSWTS 142 Query: 231 PGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVL-RSFDSMISTNCTEELENAGVEV 289 R +IVG G I E+A LG +++ D++L R I L GV+V Sbjct: 143 ATRLLIVGGGLIGCEVATTARKLGLSVTILEAGDELLVRVLGRRIGAWLRGLLTELGVQV 202 Query: 290 LKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGI 349 + V +V D L +G P D + G+ Sbjct: 203 ELGTGVVGFSGEGQLEQVMASDGRS---------FVADSALICVGAEP--ADQLARQAGL 251 Query: 350 QTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLT 383 D +IVD T KG++AVGDV L Sbjct: 252 ACDRG--VIVDHCGATLAKGVFAVGDVASWPLRA 283 Score = 28.7 bits (63), Expect = 7.1, Method: Composition-based stats. Identities = 10/30 (33%), Positives = 16/30 (53%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESH 96 L++GGG G A A +LG ++E+ Sbjct: 146 LLIVGGGLIGCEVATTARKLGLSVTILEAG 175 >3KLJ-A nrPDB Length = 385 Score = 83.4 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 59/338 (17%), Positives = 120/338 (35%), Gaps = 71/338 (21%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDH 126 L++G G G ++A+ A G C ++ M N+ + Sbjct: 12 ILILGAGPAGFSAAKAAL---------------GKCDDI------TMINSEKY------- 43 Query: 127 ADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRG-HAAFTSDPKPTIE 185 P + N ++ + + + K++I++I A + Sbjct: 44 ----LPYYRPRLNE---IIAKNKSIDDILIKKNDWYEKNNIKVITSEFATSIDPNNKLVT 96 Query: 186 V-SGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLE---ELPGRSVIVGAGY 241 + SG+K ++IA+G + + + D +++ + G++ I+G G Sbjct: 97 LKSGEKIKYEKLIIASGSIANKIKVPHADEIFSLYSYDDALKIKDECKNKGKAFIIGGGI 156 Query: 242 IAVEMAGILSALGSKTSLMIRHDKVL-RSFDSMISTNCTEELENAGVEVLKFSQVKEVKK 300 + +E+A + G+ S+ I + L R D ++L+ G+++ S +E Sbjct: 157 LGIELAQAIIDSGTPASIGIILEYPLERQLDRDGGLFLKDKLDRLGIKIYTNSNFEE--- 213 Query: 301 TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD 360 M + C++ A+G PN + + K I+V+ Sbjct: 214 -------------------MGDLIRSSCVITAVGVKPNLDFIK----DTEIASKRGILVN 250 Query: 361 EFQNTNVKGIYAVGDVCG----KALLTPVAIAAGRKLA 394 + T++K IYA GDV L +A G Sbjct: 251 DHMETSIKDIYACGDVAEFYGKNPGLINIANKQGEVAG 288 >5KVH-A nrPDB Length = 543 Score = 78.4 bits (192), Expect = 7e-15, Method: Composition-based stats. Identities = 53/266 (19%), Positives = 93/266 (34%), Gaps = 48/266 (18%) Query: 172 GHAAFTSDPKPTIEV--------SGKKYTAPHILIATGGMPSTPHESQIPGASLGITSD- 222 G A T ++V G + T LIATGG P + GA + + Sbjct: 148 GVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTL 207 Query: 223 -----GFFQLEELP---GRSVIVGAGYIAVEMAGIL----SALGSKTSLMIR----HDKV 266 F LE++ I+G G++ E+A L ALG++ + K+ Sbjct: 208 FRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARALGTEVIQLFPEKGNMGKI 267 Query: 267 LRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDV 326 L + +S E++ GV+V+ + V+ V + L + + + Sbjct: 268 LPEY---LSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRK---------VET 315 Query: 327 DCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVC--------- 377 D ++ A+G PN + L I +D G V+ I+ GD Sbjct: 316 DHIVAAVGLEPNVELAKTGGLEIDSDFGGF-RVNAELQ-ARSNIWVAGDAACFYDIKLGR 373 Query: 378 GKALLTPVAIAAGRKLAHRLFEYKED 403 + A+ +GR + + Sbjct: 374 RRVEHHDHAVVSGRLAGENMTGAAKP 399 >4FK1-A nrPDB Length = 304 Score = 76.5 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 63/360 (17%), Positives = 115/360 (31%), Gaps = 68/360 (18%) Query: 59 AGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAV 118 + A+ D VIG G GL ++ + A+ +++ Sbjct: 1 SNAMKYIDCAVIGAGPAGLNASLVLGRARKQIALFDNNT--------------------- 39 Query: 119 HSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTS 178 + +GF + +G + + + + + Sbjct: 40 -NRNRVTQNSHGFITRDGI---------KPEEFKEI--GLNEVMKYPSVHYYEKTVVMIT 87 Query: 179 DPK----PTIEVSGKKYTAPHILIATG---GMPSTPHESQIPGASL--GITSDGFFQLEE 229 + KY A +L+ATG PS P+ + G SL DG ++L++ Sbjct: 88 KQSTGLFEIVTKDHTKYLAERVLLATGMQEEFPSIPNVREYYGKSLFSCPYCDG-WELKD 146 Query: 230 LPGRSVIVGAGYIAVEMAGILSALGSKTSLMI--RHDKVLRSFDSMISTNCTEELENAGV 287 P +I+ I+ L T L+ D V+ + + +S +EL N + Sbjct: 147 QP---LII----ISENEDHTLHM----TKLVYNWSTDLVIATNGNELSQTIMDELSNKNI 195 Query: 288 EVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKL 347 V+ S G + V G I + PN + +L Sbjct: 196 PVITESIRT---LQGEGGYLKKVEFHSG-----LRIERAGGFIVPTFFRPNQ---FIEQL 244 Query: 348 GIQTDDKGHIIVDEFQNTNVKGIYAVGD-VCGKALLTPVAIAAGRKLAHRLFEYKEDSKL 406 G + G ++D+F T+ K IY G+ +A + G K A + D + Sbjct: 245 GCELQSNGTFVIDDFGRTSEKNIYLAGETTTQGPSSLIIAASQGNKAAIAINSDITDERF 304 >5MIU-A nrPDB Length = 535 Score = 71.5 bits (174), Expect = 9e-13, Method: Composition-based stats. Identities = 49/275 (17%), Positives = 90/275 (32%), Gaps = 47/275 (17%) Query: 155 NAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPG 214 N LT + + G + T LIATGG P + G Sbjct: 144 NGGVA-VLTGKKVVHLDVRGNMVKLN------DGSQITFEKCLIATGGTPRSLSAIDRAG 196 Query: 215 ASLGITSD------GFFQLEELP---GRSVIVGAGYIAVEMAGILSAL----GSKTSLMI 261 A + + F LE++ ++G G++ E+A L G + + Sbjct: 197 AEVKSRTTLFRKIGDFRALEKISREVKSITVIGEGFLGSELACALGRKSQASGIEVIQLF 256 Query: 262 R----HDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRL 317 K+L + +S E+++ GV+V+ + V+ V + L + + Sbjct: 257 PEKGNMGKILPQY---LSNWTMEKVKREGVKVMPNAIVQSVGVSGGRLLIKLKDGRK--- 310 Query: 318 PVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVC 377 + D ++ A+G PN + L I +D G V+ I+ GD Sbjct: 311 ------VETDHIVTAVGLEPNVELAKTGGLEIDSDFGGF-RVNAELQ-ARSNIWVAGDAA 362 Query: 378 ---------GKALLTPVAIAAGRKLAHRLFEYKED 403 + A+ +GR + + Sbjct: 363 CFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKP 397 >5NA1-A nrPDB Length = 408 Score = 71.1 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 51/305 (16%), Positives = 93/305 (30%), Gaps = 64/305 (20%) Query: 158 YQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPG--- 214 ++ L K + ++ +E + Y +++A G I G Sbjct: 73 VESVLKKDKVNFVQAEVTKIDRDAKKVETNQGIYDFDILVVALG---FVSETFGIEGMKD 129 Query: 215 ----ASLGITSDGF-------FQLEELPG-------RSVIVGAGYIAVEMAGILS----- 251 IT+ F ++ GAG+ VE G L+ Sbjct: 130 HAFQIENVITARELSRHIEDKFANYAASKEKDDNDLSILVGGAGFTGVEFLGELTDRIPE 189 Query: 252 ---ALG-----SKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLS 303 G K + + K+L F + + LE+ GVE + + Sbjct: 190 LCSKYGVDQNKVKITCVEAAPKMLPMFSEELVNHAVSYLEDRGVEFKIATPIVA------ 243 Query: 304 GLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQ 363 E V V G + V WA G +K + + G++ +G I+ + Sbjct: 244 CNEKGFVVEVDGEKQQLNAGTSV----WAAGVRG-SKLMEESFEGVK---RGRIVTKQDL 295 Query: 364 NTN-VKGIYAVGDV---------CGKALLTPVAIAAGRKLA---HRLFEYKEDSKLDYNN 410 N I+ +GD +A+ G +A R+ + + +Y + Sbjct: 296 TINGYDNIFVIGDCSAFIPAGEERPLPTTAQIAMQQGESVAKNIKRILNGESTEEFEYVD 355 Query: 411 IPTVV 415 TV Sbjct: 356 RGTVC 360 Score = 32.2 bits (72), Expect = 0.53, Method: Composition-based stats. Identities = 19/128 (14%), Positives = 41/128 (32%), Gaps = 30/128 (23%) Query: 232 GRSVIVGAGYIAV------------EMAGIL----SALGSKTSLMIRHDKVLRSFDSMIS 275 + +++GAGY + E A I + + + + +++ + Sbjct: 12 KKVLVLGAGYAGLQTVTKLQKAISTEEAEITLINKNEYHYEATWLHEASAGTLNYE-DVL 70 Query: 276 TNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGR 335 L+ V + EV+ + ++ I D D L+ A+G Sbjct: 71 YPVESVLKKDKVNFV-------------QAEVTKIDRDAKKVETNQGIYDFDILVVALGF 117 Query: 336 VPNTKDLS 343 V T + Sbjct: 118 VSETFGIE 125 >4NTC-A nrPDB Length = 335 Score = 64.2 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 63/350 (18%), Positives = 110/350 (31%), Gaps = 62/350 (17%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHD 125 D L+IG G GL++A A A V +S G N ++ H Sbjct: 16 DVLIIGAGPAGLSTATGLARQLHTAVVFDS----GVYRN---------------AKTQHM 56 Query: 126 HADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNN-LTKSHIEIIRGHAAFTSDPKPTI 184 H G+ E R A + L Y S IE IR ++ Sbjct: 57 HNVLGWDHRNP-------AELRAAGRADLTTRYSTIQFQNSTIEAIR---QVETNQLFEA 106 Query: 185 EVS-GKKYTAPHILIATGGMPSTPHESQIP-----GASLGITSDGFFQLEELPGRSVIVG 238 + G + +++ATG G + DG E ++ Sbjct: 107 RDNEGHSWYGRKVVLATGVRDIPLDIEGYSECWANGIYHCLFCDG--YEERGQETVGVLA 164 Query: 239 AGYIA-----VEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEE-LENAGVEVLKF 292 G IA + +A + L ++ ++ L I E + +G++ + Sbjct: 165 LGPIANPARALHLARMALRLSESVTIYTNGNEQLA---KEIQQAAEESPVGASGLKF-EA 220 Query: 293 SQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLS--LNKLGIQ 350 ++ +K V + ++ + P T+ +L + Sbjct: 221 RPIRRFEKGDVAKTVIVHLGESESKTEGFLVYN-----------PQTEVNGPFAKQLALN 269 Query: 351 TDDKGHIIVDE-FQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFE 399 + G I+ F T+V G++AVGD A++ G A L Sbjct: 270 MTEGGDILTTPPFYETSVPGVFAVGDCATPLKAVTPAVSMGSLAAGGLVA 319 >4C5O-A nrPDB Length = 357 Score = 64.2 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 49/324 (15%), Positives = 101/324 (31%), Gaps = 44/324 (13%) Query: 62 VASYDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKKVMWNTAVHS 120 + S D +VIGGG GL++ G ++++ GG + W++ Sbjct: 1 MDSVDVVVIGGGQSGLSAGYFLRRSGLSYVILDAEASPGGAWQHA--------WHSLHLF 52 Query: 121 EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQN-NLTKSHIEIIRGHAAFTSD 179 + G+P + + + + AY+++ Y L ++ + Sbjct: 53 SPAGWSSIPGWPMPASQGPYPA-RAEVLAYLAQYEQKYALPVLRPIRVQRVSHFGERL-- 109 Query: 180 PKPTIEVSGKKYTAPHILIATG--GMPSTPHESQIPGASLGITSDGFFQLEELPG--RSV 235 + G+++ A ++ ATG G TP + + + R Sbjct: 110 --RVVARDGRQWLARAVISATGTWGEAYTPEYQGLESFAGIQLHSAHYSTPAPFAGMRVA 167 Query: 236 IVGAGYIAVEMAGILSALG--SKTSLMIRHDKVLRSFDSMISTNCTEELENAG------- 286 I+G G A IL+ + ++T+ + R + + D E Sbjct: 168 IIGGGNSG---AQILAEVSTVAETTWITRTEPAFLADDVDGRVLFERATERWKAQQEGRE 224 Query: 287 ----------VEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRV 336 + ++ + L+ + + G D ++W G Sbjct: 225 PDLPPGGFGDIVMVPPVLDARARGVLAAVPPPARFSPTGMQWADGTERAFDAVIWCTGFR 284 Query: 337 PNTKDLSLNKLGIQTDDKGHIIVD 360 P L L +G + VD Sbjct: 285 PALSHLKGLDL---VTPQGQVEVD 305 >4G74-A nrPDB Length = 502 Score = 63.8 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 57/300 (19%), Positives = 95/300 (31%), Gaps = 77/300 (25%) Query: 163 TKSHIEIIRGHAAFTSDPKPTIEVSG---------------------KKYTAPHILIATG 201 K ++ A + + T+ + + +++ A G Sbjct: 107 KKGNVTYYEAEATSINPDRNTVTIKSLSAVSQLYQPENHLGLHQAEPAEIKYDYLISAVG 166 Query: 202 GMPSTPHESQIPGA------------SLGITSDGFFQLEE---LPG------RSVIV--- 237 P+T IPG SL I LE+ LP R + + Sbjct: 167 AEPNT---FGIPGVTDYGHFLKEIPNSLEIRRTFAANLEKANLLPKGDPERRRLLSIVVV 223 Query: 238 --------GAG----YIAVEMAGILSALGSKT--SLMIRHDKVLRSFDSMISTNCTEELE 283 AG Y+ ++ L AL + L+ VL F+ +S+ LE Sbjct: 224 GGGPTGVEAAGELQDYVHQDLRKFLPALAEEVQIHLVEALPIVLNMFEKKLSSYAQSHLE 283 Query: 284 NAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGR--VPNTKD 341 N ++V + V +V++ + + L+WA G P D Sbjct: 284 NTSIKVHLRTAVAKVEEKQ-----LLAKTKHEDGKITEETIPYGTLIWATGNKARPVITD 338 Query: 342 LSLNKLGIQTDDKGHIIVDEFQNTNVKG---IYAVGDV--CGKALLTPVAIAAGRKLAHR 396 L + +G + V++F VKG I+A+GD G VA LA Sbjct: 339 LFKKIPEQNSSKRG-LAVNDFLQ--VKGSNNIFAIGDNAFAGLPPTAQVAHQEAEYLAKN 395 >4USR-A nrPDB Length = 361 Score = 63.4 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 52/348 (14%), Positives = 100/348 (28%), Gaps = 72/348 (20%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 D +VIGGG L +A +++ GG ++ W++ Sbjct: 9 DVIVIGGGQAALTTAYFLRRTSLSYLLLDEQPGPGGAWLHA--------WDSLRLFSPAA 60 Query: 125 DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTK-SHIEIIRGHAAFTSDPKPT 183 + G+P + Y+ R YQ + + ++ + D Sbjct: 61 WSSIAGWPMPSPTEPGNPTRNDVIDYLRRYEDRYQFPIQRPVRVDTVTRL-----DDLWR 115 Query: 184 IEVSGKKYTAPHILIATG--GMPSTPHESQIPGASLGITSDGFFQLEE--LPGRSVIVGA 239 ++ +++ A ++ ATG P P ++ R ++VG Sbjct: 116 VQAGDQQWLARAVISATGTWSKPFIPPYEGRELFQGAQIHSAHYRTPAPFAGKRVMVVGG 175 Query: 240 GYIAVEMAGILSALGS-----------------KTS---LMIRH-------------DKV 266 G A +L+ L S + L R D+ Sbjct: 176 GNSG---AQVLAELSSVSETLWITQEPPAFLPDEVDGRVLFERATARWKAQQEGRSIDEP 232 Query: 267 LRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDV 326 F ++ E GV V G ++ Sbjct: 233 AGGFGDIVMVPPVREARERGVLV--------------AERPFARFTETGVEWADGRRENL 278 Query: 327 DCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVG 374 D ++W G P L +LG+ + G + V++ + ++ VG Sbjct: 279 DAVIWCSGFRPALDHL--RELGV-VEADGKVQVEDTRVVKQPNLWLVG 323 >5JWC-A nrPDB Length = 521 Score = 63.0 bits (152), Expect = 3e-10, Method: Composition-based stats. Identities = 44/232 (18%), Positives = 76/232 (32%), Gaps = 47/232 (20%) Query: 184 IEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGI-TSDGFFQLEE----------LPG 232 IE + K +++IA G +T + + + + + D ++ + LP Sbjct: 120 IENNKVKLFYDYLIIAVGAKTNTFNINGVDKYAYFVKDIDDALKIRKKFLDILEKCTLPN 179 Query: 233 ----------RSVIVGAGYIAVEM-AGILSALGSKTSL-------------MIRHDKVLR 268 +VG G VE+ A + + + + + +L Sbjct: 180 ISNEEKKKMLHVAVVGGGPTGVEVTAEFADFINKEVKINYKDIFNFISISIIEGGNNLLP 239 Query: 269 SFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDC 328 +F IS E N + VL V +V K ++ S+ +L Sbjct: 240 TFTQNISDFTKENFHNLNINVLTNYYVIDVDKHSFHIQSSLNKNEKKKLS-------YGL 292 Query: 329 LLWAIGRVPNTKDLSLNKLGIQTDDKGHI-IVDEFQNT-NVK--GIYAVGDV 376 L+WA G T + I I VDE + IYA+GD Sbjct: 293 LIWASGL-AQTTLIQKFLKTIPVQANNAILKVDEKLRVIGIPSNNIYAIGDC 343 >1PS9-A nrPDB Length = 671 Score = 59.9 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 45/225 (20%), Positives = 74/225 (32%), Gaps = 55/225 (24%) Query: 36 LTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVES 95 +T L AC + P P AV + V+G G GLA A AA G + + ++ Sbjct: 350 VTSCLVNPRACHETKMPILP-----AVQKKNLAVVGAGPAGLAFAINAAARGHQVTLFDA 404 Query: 96 H-KLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRL 154 H ++GG FN ++ + L Sbjct: 405 HSEIGGQ------------------------------------FNIAKQIPGKEEFYETL 428 Query: 155 NAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTA-PHILIATGGMPSTPHESQIP 213 Y+ + + + + H V+ + A ++A+G +P TP I Sbjct: 429 RY-YRRMIEVTGVTLKLNH-----------TVTADQLQAFDETILASGIVPRTPPIDGID 476 Query: 214 GASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTS 258 + D + + I+G G I + A LS G TS Sbjct: 477 HPKVLSYLDVLRDKAPVGNKVAIIGCGGIGFDTAMYLSQPGESTS 521 Score = 37.6 bits (86), Expect = 0.012, Method: Composition-based stats. Identities = 22/111 (19%), Positives = 40/111 (36%), Gaps = 12/111 (10%) Query: 232 GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLK 291 +VGAG + A +A G + +L H ++ F+ EE + Sbjct: 374 KNLAVVGAGPAGLAFAINAAARGHQVTLFDAHSEIGGQFNIAKQIPGKEEFYE---TLRY 430 Query: 292 FSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDL 342 + ++ EV G+ + + V + D + A G VP T + Sbjct: 431 YRRMIEVT----GVTLKLNHTVTADQ-----LQAFDETILASGIVPRTPPI 472 Score = 36.4 bits (83), Expect = 0.027, Method: Composition-based stats. Identities = 28/186 (15%), Positives = 61/186 (32%), Gaps = 33/186 (17%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDH 126 +IG G G +A ++ G S + G C G ++++ Sbjct: 497 VAIIGCGGIGFDTAMYLSQPGEST----SQNIAGFCNEWG-------IDSSLQQAGGLSP 545 Query: 127 ADYGFPSCEGKFNWRVIKEKR--DAYVSRLNAIYQNNLTKSHIEIIRGHA-AFTSDPKPT 183 P + K + I++ L +++I G + D Sbjct: 546 QGMQIPRSPRQIVMLQRKASKPGQGLGKTTGWIHRTTLLSRGVKMIPGVSYQKIDDDGLH 605 Query: 184 IEVSGKK--YTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSV-IVGAG 240 + ++G+ +++I G P+ + I S G++V ++G Sbjct: 606 VVINGETQVLAVDNVVICAGQEPNRALAQPL------IDS----------GKTVHLIGGC 649 Query: 241 YIAVEM 246 +A+E+ Sbjct: 650 DVAMEL 655 >5NMX-A nrPDB Length = 425 Score = 59.6 bits (143), Expect = 4e-09, Method: Composition-based stats. Identities = 61/310 (19%), Positives = 99/310 (31%), Gaps = 56/310 (18%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESH-KLGGT--------CVNVGCVPKKVMWNT- 116 V+G G GL +AR + G V E + +GGT G M+ Sbjct: 4 VAVLGAGPSGLTAARYLKQAGFEVMVFERYHHVGGTWNYTDETWMSEDGRPVYSSMYQNL 63 Query: 117 -AVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIY---QNNLTKSHIEIIR- 171 + + D+ F EG + + Y + + + H+E +R Sbjct: 64 FVNLPKELMAFPDFPFHDIEGSYVPSK---EVLKYFDNFTDAFDLRKLIKLQHHVENVRP 120 Query: 172 ---GHAAFTSDPKPTIEVSGKKYTAPHILIATGGM--PSTPHESQIPGASLGITSDGFFQ 226 G +D +E + +++ TG P P +T F+ Sbjct: 121 CESGWLVTVTDLTTMVE---HSFEFDAVVVCTGQTWCPLYPDVEGRSFFRGRLTHAHEFR 177 Query: 227 LEEL--PGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELEN 284 E R +IVGAG +MA +S + + L K L+ + + N TE Sbjct: 178 SPEPFRNKRVLIVGAGPSGHDMALHISYVSKEVFL---SRKELKPVEGLFPDNVTE---- 230 Query: 285 AGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSL 344 K + +LS DVD +L+ G LS Sbjct: 231 -----------KPLLTSLSEYTAHFSDGTS---------TDVDEILYCTGYRYRFPFLSP 270 Query: 345 NKLGIQTDDK 354 G+ D+K Sbjct: 271 EC-GVTVDEK 279 Score = 34.1 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 15/35 (42%) Query: 232 GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKV 266 R ++GAG + A L G + + R+ V Sbjct: 2 RRVAVLGAGPSGLTAARYLKQAGFEVMVFERYHHV 36 >4OVI-A nrPDB Length = 542 Score = 59.2 bits (142), Expect = 5e-09, Method: Composition-based stats. Identities = 39/243 (16%), Positives = 82/243 (33%), Gaps = 32/243 (13%) Query: 62 VASYDYLVIGGGSGGLASARRAAELGARAAVVE-SHKLGGTCVNVGCVPKKVMWNTAVHS 120 D LV+G G GL + R ELG V+E + +GG WN + Sbjct: 14 PEEVDVLVVGAGFSGLYALYRLRELGRSVHVIETAGDVGGV----------WYWNRYPGA 63 Query: 121 EFMHDHADYGFPSCEGKF---NWRVIKEKRDAYVSRLNAIYQNNLTKSHIEI---IRGHA 174 + +Y + E NW + + +N + +S I + A Sbjct: 64 RCDIESIEYCYSFSEEVLQEWNWTERYASQPEILRYINFVADKFDLRSGITFHTTVTAAA 123 Query: 175 AFTSDPKPTIEVS-GKKYTAPHILIATG--GMPSTPHESQIPGASLGITSDGFFQLEELP 231 + T++ + G + A ++++A+G +P P+ + + + G P Sbjct: 124 FDEATNTWTVDTNHGDRIRARYLIMASGQLSVPQLPNFPGLKDFAGNLYHTG--NWPHEP 181 Query: 232 -----GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVL-----RSFDSMISTNCTEE 281 R ++G G ++++ ++ ++ + R D + + Sbjct: 182 VDFSGQRVGVIGTGSSGIQVSPQIAKQAAELFVFQRTPHFAVPARNAPLDPEFLADLKKR 241 Query: 282 LEN 284 Sbjct: 242 YAE 244 Score = 29.1 bits (64), Expect = 4.3, Method: Composition-based stats. Identities = 11/65 (16%), Positives = 25/65 (38%), Gaps = 3/65 (4%) Query: 154 LNAIYQNNLTKSHIEIIRGHAAFTSDPKPT-IEVSGKKYTAPHILIATG--GMPSTPHES 210 L Y + ++ ++ +A P + S ++Y +++ATG + + Sbjct: 340 LEIDYYEMFNRDNVHLVDTLSAPIETITPRGVRTSEREYELDSLVLATGFDALTGALFKI 399 Query: 211 QIPGA 215 I G Sbjct: 400 DIRGV 404 >6JDK-A nrPDB Length = 544 Score = 58.4 bits (140), Expect = 7e-09, Method: Composition-based stats. Identities = 42/255 (16%), Positives = 79/255 (30%), Gaps = 19/255 (7%) Query: 44 MACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCV 103 M+ Q Q Q +D L++G G G+ R + G + + E+ G Sbjct: 1 MSSVQSSQTQ----KNDDAEVFDALIVGAGFNGIYQLHRLRQEGFKVRLFEAGADMGGIW 56 Query: 104 NVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSR---LNAIYQN 160 C P + + EF + + E W ++ YV + L+ + Sbjct: 57 YWNCYPGARVDSHIPIYEFSIEELWRDWNWTERFPAWDELRRYFH-YVDKKLDLSRDIRF 115 Query: 161 NLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATG--GMPSTPHESQIPGASLG 218 + S E D G A ++ TG P P+ + + Sbjct: 116 GMRVSAAEFDEAR-----DQWVIRTTDGTVVRARFFILCTGFASKPYIPNYKGLESFAGE 170 Query: 219 ITSDGFFQLEELP---GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKV-LRSFDSMI 274 G + E R +VG G V++ S + ++ R + L + Sbjct: 171 SFHTGLWPQEGASFTGKRVGVVGTGASGVQVVQEASKDAAHLTVFQRTPILALPMQQRKL 230 Query: 275 STNCTEELENAGVEV 289 + ++ E+ Sbjct: 231 DVETQQRMKADYPEI 245 >2TMD-A nrPDB Length = 729 Score = 57.6 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 62/366 (16%), Positives = 114/366 (31%), Gaps = 73/366 (19%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVE-SHKLGGTCVNVGCVPKKVMWNTAVHSEFMHD 125 L++G G G +AR E G + + + K+GG V +P Sbjct: 392 VLIVGAGPSGSEAARVLMESGYTVHLTDTAEKIGGHLNQVAALP---------------- 435 Query: 126 HADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIE 185 G W ++ R+ +++L L K+ + KP Sbjct: 436 ----------GLGEWSYHRDYRETQITKL-------LKKNK------ESQLALGQKPMTA 472 Query: 186 VSGKKYTAPHILIATGGMPSTPH-----ESQIPGASLG----ITSDGFFQLEELPGRSVI 236 +Y A ++IATG +T IPGA +T + ++ G+ V+ Sbjct: 473 DDVLQYGADKVIIATGARWNTDGTNCLTHDPIPGADASLPDQLTPEQVMDGKKKIGKRVV 532 Query: 237 VGAGYI---AVEMAGILSALGSKTSL---MIRHD--KVLRSFDSMISTNCTEELENAGVE 288 + A +A L+ G + ++ + + + +M+ +E G Sbjct: 533 ILNADTYFMAPSLAEKLATAGHEVTIVSGVHLANYMHFTLEYPNMMRRLHELHVEELGDH 592 Query: 289 VLKFSQVKEVK-----KTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLS 343 + ++ S P + D L+ GR + Sbjct: 593 FCSRIEPGRMEIYNIWGDGSKRTYRGPGVSPRDANTSHRWIEFDSLVLVTGRHSECTLWN 652 Query: 344 LNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKED 403 K E+ ++KGIY +GD L A G ++A + E Sbjct: 653 ELKA----------RESEWAENDIKGIYLIGD-AEAPRLIADATFTGHRVAREIEEANPQ 701 Query: 404 SKLDYN 409 + Y Sbjct: 702 IAIPYK 707 Score = 38.8 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 25/146 (17%), Positives = 45/146 (30%), Gaps = 7/146 (4%) Query: 201 GGMPSTPHESQIPGASLGITSD-GFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSL 259 GG P ++ G F+ + +IVGAG E A +L G L Sbjct: 358 GGPPMICTQNATAGEEYRRGWHPEKFRQTKNKDSVLIVGAGPSGSEAARVLMESGYTVHL 417 Query: 260 MIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGL-EVSMVTAVPGRLP 318 +K+ + + + E + + ++ K L E + Sbjct: 418 TDTAEKIGGHLNQVAALPGLGE-----WSYHRDYRETQITKLLKKNKESQLALGQKPMTA 472 Query: 319 VMTMIPDVDCLLWAIGRVPNTKDLSL 344 + D ++ A G NT + Sbjct: 473 DDVLQYGADKVIIATGARWNTDGTNC 498 >3UP5-A nrPDB Length = 545 Score = 57.2 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 39/253 (15%), Positives = 76/253 (30%), Gaps = 46/253 (18%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCV---NVGCVPKKVMWNTAVHSE 121 D +VIG G G+ A + G + +E+ + +GGT GC Sbjct: 11 DAVVIGAGVTGIYQAFLINQAGMKVLGIEAGEDVGGTWYWNRYPGC----------RLDT 60 Query: 122 FMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHI---EIIRGHAAFTS 178 + + + ++ W + + +N + H + + Sbjct: 61 ESYAYGYFALKGIIPEWEWSENFASQPEMLRYVNRAADAMDVRKHYRFNTRVTAARYVEN 120 Query: 179 DPKPTIEVSGKK-YTAPHILIATG--GMPSTPHESQI-----------------PGASLG 218 D + + ++ T ++ ATG P I GA G Sbjct: 121 DRLWEVTLDNEEVVTCRFLISATGPLSASRMPDIKGIDSFKGESFHSSRWPTDAEGAPKG 180 Query: 219 ITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHD-KVLRSFDSMISTN 277 + G R ++G G V++ I + + + R +S +S Sbjct: 181 VDFTG--------KRVGVIGTGATGVQIIPIAAETAKELYVFQRTPNWCTPLGNSPMSKE 232 Query: 278 CTEELENAGVEVL 290 + L N +L Sbjct: 233 KMDSLRNRYPTIL 245 >1NAA-A nrPDB Length = 541 Score = 53.8 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 16/46 (34%), Positives = 25/46 (54%), Gaps = 5/46 (10%) Query: 63 ASYDYLVIGGGSGGLASARRAAELGARAAVVESHKL-----GGTCV 103 YDY+++G G GG+ +A R +E G + ++E GGT V Sbjct: 1 TPYDYIIVGAGPGGIIAADRLSEAGKKVLLLERGGPSTKQTGGTYV 46 >2CVJ-A nrPDB Length = 180 Score = 53.4 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 32/174 (18%), Positives = 49/174 (28%), Gaps = 25/174 (14%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMI----------RHDKVLRSFDSMISTNCTEEL 282 ++VG G + A L+ G K ++ R D L Sbjct: 3 DVIVVGGGPSGLSAALFLARAGLKVLVLDGGRSKVKGVSRVPNYPGLLDEPSGEELLRRL 62 Query: 283 ENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDL 342 E + VK V V G + LL + P L Sbjct: 63 EAHARRYGAEVRPGVVKGVRDMGGVFEVETEEGVEK-------AERLLLCTHKDPTLPSL 115 Query: 343 SLNKLGIQTDDKG-HIIVDEFQNTNVKGIYAVGDVCGK-ALLTPVAIAAGRKLA 394 + +G +I DE T+ +YA G GK ++ G +A Sbjct: 116 ------LGLTRRGAYIDTDEGGRTSYPRVYAAGVARGKVPGHAIISAGDGAYVA 163 Score = 45.7 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 26/160 (16%), Positives = 50/160 (31%), Gaps = 31/160 (19%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFM 123 +D +V+GGG GL++A A G + V++ + KV Sbjct: 1 MWDVIVVGGGPSGLSAALFLARAGLKVLVLDGGR------------SKV----------K 38 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPT 183 +P + + + + +A+ R A + + K Sbjct: 39 GVSRVPNYPGLLDEPSGEELLRRLEAHARRYGAEVRPGVVK---------GVRDMGGVFE 89 Query: 184 IEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDG 223 +E A +L+ T P+ P + I +D Sbjct: 90 VETEEGVEKAERLLLCTHKDPTLPSLLGLTRRGAYIDTDE 129 >3H8L-A nrPDB Length = 409 Score = 51.1 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 50/312 (16%), Positives = 91/312 (29%), Gaps = 64/312 (20%) Query: 151 VSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTI-----EVSGKKYTAPHILIATGGMPS 205 V L L + I+ G + + S + ++++ G + Sbjct: 55 VDELKVDLSEALPEKGIQFQEGTVEKIDAKSSMVYYTKPDGSMAEEEYDYVIVGIGAHLA 114 Query: 206 TPHESQIPGASLGITSDGFF-----QLEELPGRSVIVGAG-------------------- 240 T + F +LE G ++ +G+G Sbjct: 115 TELVKGWDKYGYSVCEPEFATKLREKLESFQGGNIAIGSGPFYQGHNPKPKVPENFVPNA 174 Query: 241 YIAVE---------MAGILSALGS--KTSLMIRHD-KVLRSFDSMISTNCTEELENAGVE 288 A E + G G K + + + L G++ Sbjct: 175 DSACEGPVFEMSLMLHGYFKKKGMLDKVHVTVFSPGEYLSDLSPNSRKAVASIYNQLGIK 234 Query: 289 VLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLG 348 ++ ++KE+++ +V +P D + P T + +L Sbjct: 235 LVHNFKIKEIREH------EIVDEKGNTIP-------ADITIL---LPPYTGNPALKNST 278 Query: 349 IQT-DDKGHIIVDEFQNT-NVKGIYAVGDVC--GKALLTPVAIAAGRKLAHRLFEY-KED 403 DD G I D + +YAVGD L +A+ GR A L Sbjct: 279 PDLVDDGGFIPTDLNMVSIKYDNVYAVGDANSMTVPKLGYLAVMTGRIAAQHLANRLGVP 338 Query: 404 SKLDYNNIPTVV 415 +K+D PT+V Sbjct: 339 TKVD-KYYPTIV 349 Score = 37.6 bits (86), Expect = 0.014, Method: Composition-based stats. Identities = 20/147 (13%), Positives = 49/147 (33%), Gaps = 28/147 (19%) Query: 233 RSVIVGAGYIAVEMAGILSAL---GSKTSLMI--RHDKVLRSFD---------SMISTNC 278 + +++G + A+ A L L + ++ R + + + Sbjct: 3 KVLVLGGRFGALTAAYTLKRLVGSKADVKVINKSRFSYFRPALPHVAIGVRDVDELKVDL 62 Query: 279 TEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPN 338 +E L G++ + + V+K + + T G + + D ++ IG Sbjct: 63 SEALPEKGIQFQEGT----VEKIDAKSSMVYYTKPDGSMAEE----EYDYVIVGIGAHLA 114 Query: 339 TKDLSLNKLGIQTDDKGHIIVDEFQNT 365 T+ + D G+ + + T Sbjct: 115 TELVKGW------DKYGYSVCEPEFAT 135 >5J7X-A nrPDB Length = 549 Score = 50.3 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 40/228 (17%), Positives = 67/228 (29%), Gaps = 38/228 (16%) Query: 58 AAGAVASYDYLVIGGGSGGLASARRAA-ELGARAAVVESHK-LGGTCVN-------VGC- 107 A+ V D L+IG G G+ + EL + + E+ +GGT N V C Sbjct: 6 ASNGVLHLDALIIGSGFSGIYLLHKLRDELKLKVKIFEAESDIGGTWNNNRYPGARVDCP 65 Query: 108 VPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHI 167 VP Y P +NW + + L Sbjct: 66 VP----------------FYAYSLPEVWQSWNWTELYPN-QKEIKSYFDHVDRVLDVRKD 108 Query: 168 EIIR---GHAAFTSDP-KPTI-EVSGKKYTAPHILIATG--GMPSTPHESQIPGASLGIT 220 + F + T+ GK TA ++L+A G P + I Sbjct: 109 CLFHSRVNEGTFDEATGRWTVWTTDGKVATAKYLLVAVGFASKSYLPDWKGLDSFKGTIY 168 Query: 221 SDGFFQLEEL----PGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHD 264 + E + ++G G +++ + + L R Sbjct: 169 HSAHWPEAEEISVKGKKVAVIGTGSTGIQIFQEWAREAEEAFLFQRTP 216 >6A37-A nrPDB Length = 552 Score = 49.2 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 38/215 (17%), Positives = 78/215 (36%), Gaps = 29/215 (13%) Query: 64 SYDYLVIGGGSGGLASARRAA-ELGARAAVVES-HKLGGTCVNVGCVPKKVMWNTAVHSE 121 +D ++IG G GGL S ++ + + + ++GGT W + Sbjct: 26 DFDAIIIGAGFGGLYSLKKLRDDFNLKVRAFDRATEVGGT------------WFWNQYPG 73 Query: 122 FMHDHADYGFPSCEGKFNWRVIKEKRDAYVSR------LNAIYQNNLTKSHIEIIRG--H 173 + D + + K + + E + Y+S+ L + + + I+ G Sbjct: 74 ALSDSETHLYCYSWDKELLQEM-EIKRKYISQPDVLAYLKRVADKHDLRKDIQFETGIRS 132 Query: 174 AAFTSDPKP--TIEVSGKKYTAPHILIATG--GMPSTPHESQIP--GASLGITSDGFFQL 227 A F + + +K+TA ++ A G P+ P I L TS + Sbjct: 133 AYFDEENSFWNVTTENDEKFTARFLITALGLLAAPNLPKIKGIETFKGELHHTSRWPKDV 192 Query: 228 EELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIR 262 R ++G G V++ +++ ++ R Sbjct: 193 TFSGKRVGVIGTGSTGVQVITAIASQVKHLTVFQR 227 >2VOU-A nrPDB Length = 397 Score = 49.2 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 20/100 (20%), Positives = 31/100 (31%), Gaps = 2/100 (2%) Query: 232 GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMIST--NCTEELENAGVEV 289 R +VG + A +L G + R + L F + I L GVE+ Sbjct: 6 DRIAVVGGSISGLTAALMLRDAGVDVDVYERSPQPLSGFGTGIVVQPELVHYLLEQGVEL 65 Query: 290 LKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCL 329 S + + L V +VP + L Sbjct: 66 DSISVPSSSMEYVDALTGERVGSVPADWRFTSYDSIYGGL 105 >5CQF-A nrPDB Length = 443 Score = 48.4 bits (114), Expect = 7e-06, Method: Composition-based stats. Identities = 65/437 (14%), Positives = 118/437 (27%), Gaps = 109/437 (24%) Query: 66 DYLVIGGGSGG--LASARRAAEL------GARAAVVESHK---------LGGTCVN---- 104 D + IG G G LA A A +E+ L GT +N Sbjct: 15 DAICIGFGPAGIALACAFEDAREASQPLGDLSIGYLEAAPDTQWHRELLLAGTDINHHVF 74 Query: 105 VGCV----PKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQN 160 V P+ + + W V Sbjct: 75 RDLVTPRNPRSRFSFAMYLKDQGRMFDFGLLGRPASRHEWSDYLGWVSRQVDGHTRF--- 131 Query: 161 NLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPH-ESQIPGASLGI 219 + + I + + + ++++++G P P + G +L Sbjct: 132 ---DTPVTEIDPVIRNGRLQEVRVRTPQGSFATRNLVLSSGSAPRIPQAFEALLGPTLFH 188 Query: 220 TSDGFFQL----EELPGRSVIVGAGYIAVE-------------------MAGI-LSALGS 255 TS +L ++LP R +++G+G A E AG L+ LG Sbjct: 189 TSRFLTRLQAFGKQLPKRWLVLGSGQSASESVLELVSRDPAIEVHSVHRCAGFKLTQLGQ 248 Query: 256 ---------KTSLMI-----RHDKVL--------RSFDSMISTNCTEELENAGV----EV 289 + L D + + + Sbjct: 249 FPNRVFAPDHVDYFHSLNPAARQRFLDWSRSTNYAGIDPDERQKLFSLIYEDSIAGRTRL 308 Query: 290 LK--FSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRV-----PNTKDL 342 +S + ++ T G V + T + +VD ++ G P L Sbjct: 309 HTYAYSVISAIEHTADGYRVELTDTF----SQRTRVLEVDAVVLGTGYQQYLIPPLLSGL 364 Query: 343 SLNKLGIQTDDKGHIIVDEFQNTNVKG-----IYAVG------DVCGKALLTPVAIAAGR 391 + D G +++D +G I+ G + + +A+ AGR Sbjct: 365 QPW---LAADVDGGLLIDRDYRVATQGACDVNIWVNGLSERSHGISDSQSFSLMALRAGR 421 Query: 392 KLA--HRLFEYKEDSKL 406 + R E D+ L Sbjct: 422 IASALERAVEPATDAPL 438 >5BR7-A nrPDB Length = 393 Score = 48.0 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 17/41 (41%), Positives = 25/41 (60%), Gaps = 2/41 (4%) Query: 62 VASYDYLVIGGGSGGLASARRAA-ELGARAAVVESHK-LGG 100 ++ +D +V+G G GL A RAA +LG + +VE LGG Sbjct: 1 MSDFDLIVVGSGLFGLTVAERAASQLGKKVLIVEKRSHLGG 41 >3K30-A nrPDB Length = 690 Score = 47.6 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 65/348 (18%), Positives = 110/348 (31%), Gaps = 92/348 (26%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKKVMWNTAVHSEFMHD 125 LV+G G GL +AR G + E+ + LGG + Sbjct: 394 VLVVGAGPSGLEAARALGVRGYDVVLAEAGRDLGG--------------------RVTQE 433 Query: 126 HADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIE 185 A G + W +KE R+A ++ L ++EI R D Sbjct: 434 SALPGLSA------WGRVKEYREAVLAEL----------PNVEIYRESPMTGDDIV---- 473 Query: 186 VSGKKYTAPHILIATGGMPSTPHESQIPGASLGI-------TSDGFFQLEELPGRSVIVG 238 ++ H++ ATG T ++ +L I D F G+ V+V Sbjct: 474 ----EFGFEHVITATGATWRTDGVARFHTTALPIAEGMQVLGPDDLFAGRLPDGKKVVVY 529 Query: 239 -------AGYIAVEMAGILSALGSKTSLM----IRHDKVLRSFDSMISTNCTEELENAGV 287 G + A +L+ G + S++ +F+ L G Sbjct: 530 DDDHYYLGGVV----AELLAQKGYEVSIVTPGAQVSSWTNNTFE---VNRIQRRLIENG- 581 Query: 288 EVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKL 347 V V + V + + D ++ R+P ++L L+ Sbjct: 582 -------VARVTDHAVVAVGAGGVTVRDTYASIERELECDAVVMVTARLPR-EELYLDL- 632 Query: 348 GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAH 395 + D G I +V+GI GD A+ +GR+ A Sbjct: 633 -VARRDAGEIA-------SVRGI---GD-AWAPGTIAAAVWSGRRAAE 668 Score = 33.7 bits (76), Expect = 0.19, Method: Composition-based stats. Identities = 11/46 (23%), Positives = 16/46 (34%) Query: 228 EELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSM 273 +E R ++VGAG +E A L G L + Sbjct: 388 KESDARVLVVGAGPSGLEAARALGVRGYDVVLAEAGRDLGGRVTQE 433 >1Y56-A nrPDB Length = 493 Score = 47.2 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 53/289 (18%), Positives = 90/289 (31%), Gaps = 75/289 (25%) Query: 90 AAVVE-SHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRD 148 A++E LGG D G + R + E Sbjct: 133 VALIEERGWLGG------------------------DMWLKGIKQEGFNKDSRKVVE--- 165 Query: 149 AYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGK-KYTAPHILIATGGMPSTP 207 V +LN + L S + + F P + + A +++ATG Sbjct: 166 ELVGKLNENTKIYLETSALGVFDKGEYFL---VPVVRGDKLIEILAKRVVLATGA----- 217 Query: 208 HESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILS-ALGSKTSLMIRHDKV 266 I S F+ ++PG V A+E+ + A G K ++ Sbjct: 218 -----------IDSTMLFENNDMPG----VFRRDFALEVMNVWEVAPGRKVAV------- 255 Query: 267 LRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDV 326 + +ELE G++ + VK V+ V + V Sbjct: 256 ----TGSKADEVIQELERWGIDYVHIPNVKRVEGNEKVERVIDMNN---------HEYKV 302 Query: 327 DCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIV-DEFQNTNVKGIYAVG 374 D L++A GR P+ ++ ++ + V DE+ GIY G Sbjct: 303 DALIFADGRRPDINPITQAGGKLRFRRGYYSPVLDEYHRIK-DGIYVAG 350 >3T14-A nrPDB Length = 437 Score = 46.1 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 50/335 (14%), Positives = 109/335 (32%), Gaps = 83/335 (24%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDH 126 +++G G+GG+ +A + A+ H++ + + + +F+ + Sbjct: 7 VVILGAGTGGMPAA-----YEMKEALGSGHEV-------------TLISANDYFQFVPSN 48 Query: 127 ADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEV 186 G ++ + ++ + + I I A I + Sbjct: 49 PWVG-------------VGWKER--DDIAFPIRHYVERKGIHFIAQSAEQIDAEAQNITL 93 Query: 187 -SGKKYTAPHILIATGGMPST-------PHESQIPGASLGITSDGFFQLEELPGRS---V 235 G +++IATG + PHE + + ++ F + R + Sbjct: 94 ADGNTVHYDYLMIATGPKLAFENVPGSDPHEGPVQSIATVDHAERAFAEYQALLREPGPI 153 Query: 236 IVGAGYIAVEMAGILSALG--SKTSLMIRHDKVLRSFDSMI------------------- 274 ++GA MAG S G + ++++ D R I Sbjct: 154 VIGA------MAGA-SCFGPAYEYAMIVASDLKKRGMRDKIPSFTFITSEPYIGHLGIQG 206 Query: 275 ----STNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLL 330 T+ L+ G+E +V +V+ + + V+ V + M + ++ Sbjct: 207 VGDSKGILTKGLKEEGIEAYTNCKVTKVE--DNKMYVTQVDEKGETIKEMVLPVKFGMMI 264 Query: 331 WAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNT 365 A VP + + G ++VDE Q + Sbjct: 265 PAFKGVPAVAGVEG-----LCNPGGFVLVDEHQRS 294 >4Y4N-A nrPDB Length = 286 Score = 46.1 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 13/35 (37%), Positives = 20/35 (57%) Query: 62 VASYDYLVIGGGSGGLASARRAAELGARAAVVESH 96 + D ++GGG GL +AR A+ G + V+E H Sbjct: 50 IIDVDVAIVGGGPSGLTAARYIAKEGYKVVVLERH 84 Score = 31.8 bits (71), Expect = 0.66, Method: Composition-based stats. Identities = 9/31 (29%), Positives = 14/31 (45%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRH 263 IVG G + A ++ G K ++ RH Sbjct: 54 DVAIVGGGPSGLTAARYIAKEGYKVVVLERH 84 >3RHA-A nrPDB Length = 482 Score = 46.1 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 13/36 (36%), Positives = 21/36 (58%), Gaps = 1/36 (2%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVE-SHKLGG 100 D +++G G GL +AR + G AV+E ++GG Sbjct: 9 DVVIVGAGPSGLTAARELKKAGLSVAVLEARDRVGG 44 Score = 35.7 bits (81), Expect = 0.057, Method: Composition-based stats. Identities = 12/40 (30%), Positives = 19/40 (47%) Query: 227 LEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKV 266 ++ L VIVGAG + A L G +++ D+V Sbjct: 3 MQNLDRDVVIVGAGPSGLTAARELKKAGLSVAVLEARDRV 42 >2ZXH-A nrPDB Length = 637 Score = 45.7 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 37/198 (18%), Positives = 64/198 (32%), Gaps = 46/198 (23%) Query: 54 GPPPAAGAVA----SYDYLVIGGGSGGLASARRAAELGARAAVV---------------- 93 G PA +A +D +VIGGG G+ +A AA +GA+ A+ Sbjct: 13 GLVPAGSHMAWVVDEFDVVVIGGGHAGIEAALAAARMGAKTAMFVLNADTIGQMSCNPAI 72 Query: 94 ----------ESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVI 143 E LGG K + T + + ++ S + + + Sbjct: 73 GGIAKGIVVREIDALGGEM-------GKAIDQTGIQFKMLNTRKGKAVQSPRAQADKKRY 125 Query: 144 KEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATG-- 201 +E +Y + ++II + G +Y +++ TG Sbjct: 126 REYMKKVCENQENLY--IKQEEVVDIIVKNNQVVGVRTNL----GVEYKTKAVVVTTGTF 179 Query: 202 -GMPSTPHESQIPGASLG 218 + IPG LG Sbjct: 180 LNGVIYIGDKMIPGGRLG 197 Score = 31.1 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 14/85 (16%), Positives = 37/85 (43%), Gaps = 3/85 (3%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIR-HDKVLRSFDSMISTNCTEELENAGVEVLK 291 V++G G+ +E A + +G+KT++ + D + + + + + ++ L Sbjct: 29 DVVVIGGGHAGIEAALAAARMGAKTAMFVLNADTIGQMSCNPAIGGIAKGIVVREIDALG 88 Query: 292 FSQVKEVKKTLSGLEVSMVTAVPGR 316 K + +G++ M+ G+ Sbjct: 89 GEMGKAI--DQTGIQFKMLNTRKGK 111 >2BXR-A nrPDB Length = 527 Score = 45.3 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 23/105 (21%), Positives = 41/105 (39%), Gaps = 11/105 (10%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVE-SHKLGG---TCVN--VGCVPKKVMWNTA 117 +D +VIGGG GL++A+ E G V+E ++GG T N V V + Sbjct: 13 MFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGP 72 Query: 118 VHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNL 162 + + + G + + + E+ YV ++ Sbjct: 73 TQNRILRLSKELGIETYKV-----NVSERLVQYVKGKTYPFRGAF 112 Score = 40.3 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 8/34 (23%), Positives = 16/34 (47%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKV 266 V++G G + A +L+ G ++ D+V Sbjct: 15 DVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRV 48 >6ER9-A nrPDB Length = 549 Score = 45.3 bits (106), Expect = 7e-05, Method: Composition-based stats. Identities = 29/223 (13%), Positives = 70/223 (31%), Gaps = 33/223 (14%) Query: 61 AVASYDYLVIGGGSGGLASARRA-AELGARAAVVES-HKLGGTCVNVGCVPKKVMWNTAV 118 + D +VIG G GG+ + + E G + GGT W Sbjct: 6 SPTVVDAVVIGAGFGGIYAVHKLHNEQGLTVVGFDKADGPGGT------------WYWNR 53 Query: 119 HSEFMHDHADYGFPSCEGKFNWRVIK--EKRDAYVSR------LNAIYQNNLTKSHI--- 167 + + D + + F+ +++ + Y+++ L ++ + H Sbjct: 54 YPGALSDTESHLY---RFSFDRDLLQDGTWKTTYITQPEILEYLESVVDRFDLRRHFRFG 110 Query: 168 EIIRGHAAFTSDPKPTIEVS-GKKYTAPHILIATG--GMPSTPHESQIPGASLGITSDGF 224 + + + G+ Y A +++ A G + P + Sbjct: 111 TEVTSAIYLEDENLWEVSTDKGEVYRAKYVVNAVGLLSAINFPDLPGLDTFEGETIHTAA 170 Query: 225 FQLEE--LPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDK 265 + + R ++G G ++ L+ ++ +R + Sbjct: 171 WPEGKNLAGKRVGVIGTGSTGQQVITALAPEVEHLTVFVRTPQ 213 >4RG3-A nrPDB Length = 548 Score = 44.9 bits (105), Expect = 8e-05, Method: Composition-based stats. Identities = 29/221 (13%), Positives = 72/221 (32%), Gaps = 39/221 (17%) Query: 66 DYLVIGGGSGGLASARRA-AELGARAAVVES-HKLGGTCVNVGCVPKKVMWNTAVHSEFM 123 D +VIG G GG+ + + ELG + GGT W + + Sbjct: 18 DAVVIGAGFGGIYAVHKLHHELGLTTVGFDKADGPGGT------------WYWNRYPGAL 65 Query: 124 HDHADYGFPSCEGKFNWRVIKE--KRDAYV--SRLNAIYQNNLTKSHIEIIRGHAA---- 175 D + + F+ +++E + Y+ + ++ + + + Sbjct: 66 SDTESHLY---RFSFDRDLLQESTWKTTYITQPEILEYLEDVVDRFDLRRHFKFGTEVTS 122 Query: 176 ---FTSDPKPTIEVS-GKKYTAPHILIATG--GMPSTPHESQIPGASLGITSDGFFQLEE 229 + + G+ Y A +++ A G + P+ + + + Sbjct: 123 ALYLDDENLWEVTTDHGEVYRAKYVVNAVGLLSAINFPNLPGLDTFEGETIHTAAWPEGK 182 Query: 230 --LPGRSVIVGAGYIAVEMAGILSALGSKT---SLMIRHDK 265 R ++G G ++++L + ++ +R + Sbjct: 183 SLAGRRVGVIGTGSTG---QQVITSLAPEVEHLTVFVRTPQ 220 >4Y4M-A nrPDB Length = 290 Score = 44.9 bits (105), Expect = 8e-05, Method: Composition-based stats. Identities = 12/31 (38%), Positives = 18/31 (58%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVESH 96 D +++G G GL AR A+ G + V+E H Sbjct: 61 DVVIVGAGPSGLTCARYLAKEGFKVVVLERH 91 Score = 37.2 bits (85), Expect = 0.019, Method: Composition-based stats. Identities = 13/38 (34%), Positives = 19/38 (50%) Query: 226 QLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRH 263 L+ + VIVGAG + A L+ G K ++ RH Sbjct: 54 WLDIVEADVVIVGAGPSGLTCARYLAKEGFKVVVLERH 91 >3NIX-A nrPDB Length = 421 Score = 44.2 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 31/201 (15%), Positives = 60/201 (29%), Gaps = 41/201 (20%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVESHK-----LGGTCVNVGCVPK---------- 110 D LVIG G G +A + G + +VE K +G + + C+ Sbjct: 7 DVLVIGAGPAGTVAASLVNKSGFKVKIVEKQKFPRFVIGESLLPR-CMEHLDEAGFLDAV 65 Query: 111 ----------------KVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRL 154 K + + S+ + ++ + G F+ + E V Sbjct: 66 KAQGFQQKFGAKFVRGKEIADF-NFSDQFSNGWNWTWQVPRGNFDKTLADEAARQGVD-- 122 Query: 155 NAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPG 214 + + I+ + I + ++ A I+ A+G P + Sbjct: 123 ------VEYEVGVTDIKFFGTDSVTTIEDINGNKREIEARFIIDASGYGRVIPRMFGLDK 176 Query: 215 ASLGITSDGFFQLEELPGRSV 235 S + F + R V Sbjct: 177 PSGFESRRTLFTHIKDVKRPV 197 >1ZOV-A nrPDB Length = 386 Score = 44.2 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 11/33 (33%), Positives = 20/33 (60%) Query: 63 ASYDYLVIGGGSGGLASARRAAELGARAAVVES 95 +D +V+G GS G+A+ A+ G + +V+S Sbjct: 2 THFDVIVVGAGSMGMAAGYYLAKQGVKTLLVDS 34 Score = 29.1 bits (64), Expect = 5.1, Method: Composition-based stats. Identities = 10/34 (29%), Positives = 16/34 (47%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKV 266 ++VGAG + + L+ G KT L+ D Sbjct: 5 DVIVVGAGSMGMAAGYYLAKQGVKTLLVDSFDPP 38 >1O5W-A nrPDB Length = 534 Score = 43.8 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 18/46 (39%), Positives = 27/46 (58%), Gaps = 3/46 (6%) Query: 56 PPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVE-SHKLGG 100 P AG + +D +VIGGG GLA+A+ +E V+E ++GG Sbjct: 15 PNLAGHM--FDVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 58 Score = 36.1 bits (82), Expect = 0.041, Method: Composition-based stats. Identities = 8/34 (23%), Positives = 15/34 (44%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKV 266 V++G G + A +LS ++ D+V Sbjct: 23 DVVVIGGGISGLAAAKLLSEYKINVLVLEARDRV 56 >1I8T-A nrPDB Length = 367 Score = 43.8 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 16/81 (19%), Positives = 28/81 (34%), Gaps = 4/81 (4%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKKVMWNTAVHSEF 122 YDY+++G G G A +L + V+E +GG C ++ A Sbjct: 1 MYDYIIVGSGLFGAVCANELKKLNKKVLVIEKRNHIGGNAYTEDCEGIQIHKYGA---HI 57 Query: 123 MHDHADYGFPSCEGKFNWRVI 143 H + Y + + Sbjct: 58 FHTNDKYIWDYVNDLVEFNRF 78 >3KVE-A nrPDB Length = 486 Score = 43.4 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 10/35 (28%), Positives = 19/35 (54%) Query: 231 PGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDK 265 P V+VGAG + A +L+ G K +++ ++ Sbjct: 33 PKHVVVVGAGMSGLSAAYVLAGAGHKVTVLEASER 67 Score = 33.7 bits (76), Expect = 0.22, Method: Composition-based stats. Identities = 11/34 (32%), Positives = 19/34 (55%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKLGG 100 +V+G G GL++A A G + V+E+ + G Sbjct: 36 VVVVGAGMSGLSAAYVLAGAGHKVTVLEASERAG 69 >6CR0-A nrPDB Length = 440 Score = 43.4 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 16/45 (35%), Positives = 25/45 (55%), Gaps = 3/45 (6%) Query: 59 AGAVAS--YDYLVIGGGSGGLASARRAAELGARAAVVE-SHKLGG 100 + A+ YD +V+G G GL +AR + G ++E H+LGG Sbjct: 1 SNAMTEKIYDAIVVGAGFSGLVAARELSAQGRSVLIIEARHRLGG 45 Score = 31.1 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 9/32 (28%), Positives = 17/32 (53%) Query: 235 VIVGAGYIAVEMAGILSALGSKTSLMIRHDKV 266 ++VGAG+ + A LSA G ++ ++ Sbjct: 12 IVVGAGFSGLVAARELSAQGRSVLIIEARHRL 43 >2BRY-A nrPDB Length = 497 Score = 43.4 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 14/29 (48%), Positives = 17/29 (58%) Query: 68 LVIGGGSGGLASARRAAELGARAAVVESH 96 LV+G G GL +A A LGAR +VE Sbjct: 96 LVVGAGPCGLRAAVELALLGARVVLVEKR 124 Score = 29.9 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 20/36 (55%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLR 268 + ++VGAG + A L+ LG++ L+ + K R Sbjct: 94 KCLVVGAGPCGLRAAVELALLGARVVLVEKRIKFSR 129 >2JB2-A nrPDB Length = 489 Score = 43.4 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 14/39 (35%), Positives = 21/39 (53%), Gaps = 1/39 (2%) Query: 63 ASYDYLVIGGGSGGLASARRAAELGARAAVVE-SHKLGG 100 S+ +V+GGG GL SA + G + V+E + GG Sbjct: 10 GSHSVVVLGGGPAGLCSAFELQKAGYKVTVLEARTRPGG 48 Score = 31.1 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 7/34 (20%), Positives = 14/34 (41%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKV 266 V++G G + A L G K +++ + Sbjct: 13 SVVVLGGGPAGLCSAFELQKAGYKVTVLEARTRP 46 >4TXK-A nrPDB Length = 615 Score = 43.4 bits (101), Expect = 3e-04, Method: Composition-based stats. Identities = 14/29 (48%), Positives = 17/29 (58%) Query: 68 LVIGGGSGGLASARRAAELGARAAVVESH 96 LV+G G GL +A A LGAR +VE Sbjct: 88 LVVGAGPCGLRAAVELALLGARVVLVEKR 116 Score = 29.9 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 20/36 (55%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLR 268 + ++VGAG + A L+ LG++ L+ + K R Sbjct: 86 KCLVVGAGPCGLRAAVELALLGARVVLVEKRIKFSR 121 >2UZZ-A nrPDB Length = 372 Score = 43.0 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 11/34 (32%), Positives = 17/34 (50%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHKL 98 YD ++IG GS G A+ A G + ++H Sbjct: 3 YDLIIIGSGSVGAAAGYYATRAGLNVLMTDAHMP 36 >3BHF-A nrPDB Length = 390 Score = 43.0 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 10/33 (30%), Positives = 21/33 (63%) Query: 63 ASYDYLVIGGGSGGLASARRAAELGARAAVVES 95 +D +V+G GS G+A+ + A+ G + +V++ Sbjct: 3 THFDVIVVGAGSMGMAAGYQLAKQGVKTLLVDA 35 >4MOP-A nrPDB Length = 633 Score = 43.0 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 12/49 (24%), Positives = 20/49 (40%) Query: 50 PQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKL 98 P P G YD +++G G G AR G + A+ + ++ Sbjct: 32 PLPGPDKKVPGMDIKYDVVIVGSGPIGCTYARELVGAGYKVAMFDIGEI 80 >4TLZ-A nrPDB Length = 443 Score = 42.6 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 20/106 (18%), Positives = 36/106 (33%), Gaps = 11/106 (10%) Query: 164 KSHIEIIR-GHAAFTSDPKPTIEV--SGKKYTAPHILIATGGMPSTPHESQIPGASLGIT 220 S + IR G + + + A +I+I+TG +P P + + Sbjct: 144 DSEVTAIRPGPGRPVDSVLVDVSTPEATRTVEARNIVISTGLVPRMP--AGVQSDEFVWH 201 Query: 221 SDGFFQ--LEELPG---RSVIVGAGYIAVEMAGILSALGSKTSLMI 261 S F + P R + G G A E+ L +++ Sbjct: 202 SSRFLDHFRDRDPRSLRRVAVAGGGQSAAEIVRFLHDNRPD-TVVH 246 >2GMH-A nrPDB Length = 584 Score = 42.6 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 16/50 (32%), Positives = 24/50 (48%), Gaps = 12/50 (24%) Query: 66 DYLVIGGGSGGLASARR----AAEL--GARAAVVES------HKLGGTCV 103 D +++G G GL++A R AA+ R +VE H L G C+ Sbjct: 37 DVVIVGAGPAGLSAATRLKQLAAQHEKDLRVCLVEKAAHIGAHTLSGACL 86 >1REO-A nrPDB Length = 486 Score = 42.6 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 10/35 (28%), Positives = 19/35 (54%) Query: 231 PGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDK 265 P V+VGAG + A +LS G + +++ ++ Sbjct: 33 PKHVVVVGAGMSGLSAAYVLSGAGHQVTVLEASER 67 Score = 32.2 bits (72), Expect = 0.53, Method: Composition-based stats. Identities = 42/292 (14%), Positives = 87/292 (29%), Gaps = 58/292 (19%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVES-HKLGG---TCVNVGCVPKKVMWNTAVHSEF 122 +V+G G GL++A + G + V+E+ + GG T N K W + Sbjct: 36 VVVVGAGMSGLSAAYVLSGAGHQVTVLEASERAGGRVRTYRND-----KEDWYANLGPMR 90 Query: 123 M-HDHADYGFPSCEGKFNWRVIKEKRDA---YVSRLNAIYQNNLTKSHI--------EII 170 + H + ++ D ++ + + E Sbjct: 91 LPEKHRIVREYIRKFGLQLNEFSQENDNAWYFIKNIRKRVGEVKKDPGVLKYPVKPSEEG 150 Query: 171 RGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEE- 229 + + + K+ +IL S + L+E Sbjct: 151 KSAGQLYEESLGKVVEELKRTNCSYIL-----------------NKYDTYSTKEYLLKEG 193 Query: 230 --LPGRSVIVGAGYIAVEMAGILSALGSKT---SLMI---RHDKVLRSFDSMISTNCTEE 281 PG ++G + E +G + + R D+++ D + T+ Sbjct: 194 NLSPGAVDMIG--DLMNEDSGYYVSFPESLRHDDIFAYEKRFDEIVGGMDK-LPTSMYRA 250 Query: 282 LENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAI 333 +E +V +QV +++K + V T V D ++ Sbjct: 251 IEE---KVHLNAQVIKIQKNAEKVTVVYQTPAKEMASVT-----ADYVIVCT 294 >3ATQ-A nrPDB Length = 453 Score = 42.6 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 36/176 (20%), Positives = 60/176 (34%), Gaps = 36/176 (20%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESH---KLG----GTCVNVGCVPKKVMWNT- 116 YD L+IGGG G ++A + + G + +V+S ++G G V+ K M Sbjct: 7 YDVLIIGGGFAGSSAAYQLSRRGLKILLVDSKPWNRIGDKPCGDAVSKAHFDKLGMPYPK 66 Query: 117 --------------AVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVS--RLNAIYQN 160 + + + GF +N RV+KE +D V L + Sbjct: 67 GEELENKINGIKLYSPDMQTVWTVNGEGFELNAPLYNQRVLKEAQDRGVEIWDLTTAMKP 126 Query: 161 NLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGG----MPSTPHESQI 212 ++G F + V + ++ ATG P E I Sbjct: 127 IFEDG---YVKGAVLFNRRTNEELTV-----YSKVVVEATGYSRSFRSKLPPELPI 174 Score = 33.0 bits (74), Expect = 0.31, Method: Composition-based stats. Identities = 15/81 (18%), Positives = 31/81 (38%), Gaps = 3/81 (3%) Query: 227 LEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAG 286 ++EL +I+G G+ A LS G K L+ + G Sbjct: 2 MKELKYDVLIIGGGFAGSSAAYQLSRRGLKILLVDSKPWNRIGDKPCGDAVSKAHFDKLG 61 Query: 287 VEVLKFSQVKEVKKTLSGLEV 307 + K +E++ ++G+++ Sbjct: 62 MPYPKG---EELENKINGIKL 79 >3ABT-A nrPDB Length = 662 Score = 42.6 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 10/35 (28%), Positives = 19/35 (54%) Query: 232 GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKV 266 G+ +I+G+G + A L + G +L+ D+V Sbjct: 108 GKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRV 142 Score = 37.6 bits (86), Expect = 0.013, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 20/35 (57%), Gaps = 1/35 (2%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVE-SHKLGG 100 ++IG G GLA+AR+ G ++E ++GG Sbjct: 110 VIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGG 144 >2VVL-G nrPDB Length = 495 Score = 42.2 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 13/43 (30%), Positives = 21/43 (48%), Gaps = 1/43 (2%) Query: 59 AGAVASYDYLVIGGGSGGLASARRAAELGARAAVVE-SHKLGG 100 +D +VIGGG GL + R G + ++E ++GG Sbjct: 34 TDKDGPWDVIVIGGGYCGLTATRDLTVAGFKTLLLEARDRIGG 76 Score = 35.7 bits (81), Expect = 0.050, Method: Composition-based stats. Identities = 10/39 (25%), Positives = 20/39 (51%) Query: 228 EELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKV 266 ++ P +++G GY + L+ G KT L+ D++ Sbjct: 36 KDGPWDVIVIGGGYCGLTATRDLTVAGFKTLLLEARDRI 74 >5EQD-A nrPDB Length = 400 Score = 42.2 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 17/42 (40%), Positives = 24/42 (57%), Gaps = 2/42 (4%) Query: 61 AVASYDYLVIGGGSGGLASARRAA-ELGARAAVVESHK-LGG 100 + ++D V+G G GL A RAA +LG R V+E +GG Sbjct: 1 STGNFDLFVVGSGFFGLTIAERAATQLGKRVLVIERRPHIGG 42 Score = 33.4 bits (75), Expect = 0.28, Method: Composition-based stats. Identities = 16/72 (22%), Positives = 28/72 (38%), Gaps = 15/72 (20%) Query: 221 SDGFFQLEELPGRSVIVGAGYIAVEMAG-ILSALGSKTSLMIRHDKVLRSFDSMISTNCT 279 S G F L +VG+G+ + +A + LG + ++ R + + Sbjct: 1 STGNFDL-------FVVGSGFFGLTIAERAATQLGKRVLVIERRPHIGG-------NAYS 46 Query: 280 EELENAGVEVLK 291 E G+EV K Sbjct: 47 EPEPETGIEVHK 58 >3HYW-A nrPDB Length = 430 Score = 42.2 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 26/104 (25%), Positives = 41/104 (39%), Gaps = 13/104 (12%) Query: 161 NLTKSHIEIIRGHAAFTSDPKPTIEV-SGKKYTAPHILIATGGMPSTPHESQIPGASLGI 219 L K +IE I A T+ SGKK +++IATG E Q ++ Sbjct: 65 LLPKFNIEFINEKAESIDPDANTVTTQSGKKIEYDYLVIATGPKLVFGAEGQEENSTSIC 124 Query: 220 TSDGFFQLEELPGRS------VIVGA--GYI----AVEMAGILS 251 T++ + ++ V++GA G A E A +L Sbjct: 125 TAEHALETQKKLQELYANPGPVVIGAIPGVSCFGPAYEFALMLH 168 >5L3D-A nrPDB Length = 852 Score = 41.8 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 10/35 (28%), Positives = 19/35 (54%) Query: 232 GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKV 266 G+ +I+G+G + A L + G +L+ D+V Sbjct: 279 GKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRV 313 Score = 37.2 bits (85), Expect = 0.020, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 20/35 (57%), Gaps = 1/35 (2%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVE-SHKLGG 100 ++IG G GLA+AR+ G ++E ++GG Sbjct: 281 VIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGG 315 >4AP1-A nrPDB Length = 549 Score = 41.5 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 38/220 (17%), Positives = 75/220 (34%), Gaps = 23/220 (10%) Query: 56 PPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVE-SHKLGGTCVNVGCVPKKVMW 114 P A SYD +V+G G GL + R G E + +GG W Sbjct: 13 PDATTGTTSYDVVVVGAGIAGLYAIHRFRSQGLTVRAFEAASGVGGV----------WYW 62 Query: 115 NTAVHSEFMHDHADYGF---PSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHI---E 168 N + + DY + P E ++NW + ++ L + + I Sbjct: 63 NRYPGARCDVESIDYSYSFSPELEQEWNWSEKYATQPEILAYLEHVADRFDLRRDIRFDT 122 Query: 169 IIRGHAAFTSDPKPTIEVS-GKKYTAPHILIATG--GMPSTPHESQIPGASLGITSDGFF 225 + + T+ G + +A +++A G +TP + + I + Sbjct: 123 RVTSAVLDEEGLRWTVRTDRGDEVSARFLVVAAGPLSNANTPAFDGLDRFTGDIVHTARW 182 Query: 226 QLEELP---GRSVIVGAGYIAVEMAGILSALGSKTSLMIR 262 + + R ++G G ++ I++ + + R Sbjct: 183 PHDGVDFTGKRVGVIGTGSSGIQSIPIIAEQAEQLFVFQR 222 Score = 31.4 bits (70), Expect = 0.87, Method: Composition-based stats. Identities = 16/113 (14%), Positives = 37/113 (32%), Gaps = 8/113 (7%) Query: 94 ESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSR 153 E KLGG + P ++ ++ + + + +D + Sbjct: 284 ERWKLGGV-LFSAAFPDQL--TDPAANDTARAFWEEKIRAVVDDPAVAELLTPKDHAIGA 340 Query: 154 LN----AIYQNNLTKSHIEIIRGHAA-FTSDPKPTIEVSGKKYTAPHILIATG 201 + Y + ++E++ + + I +G Y I++ATG Sbjct: 341 KRIVTDSGYYETYNRDNVELVDLRSTPIVGMDETGIVTTGAHYDLDMIVLATG 393 >2E5V-A nrPDB Length = 472 Score = 41.1 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 51/373 (13%), Positives = 103/373 (27%), Gaps = 99/373 (26%) Query: 69 VIGGGSGGLASARRAAELGARAAVVESH--------KLGGTCVNVG-------------- 106 +IG G GL++ G + ++ GG +VG Sbjct: 4 IIGSGIAGLSAGVALRRAGKKVTLISKRIDGGSTPIAKGGVAASVGSDDSPELHAQDTIR 63 Query: 107 -----CVPKKVMWNTAVHSEFMHDHADYGFPSC-----EGKFNWRVIKEKRDAYVSRLNA 156 C K V + T+ + +GF EG R + + D + Sbjct: 64 VGDGLCDVKTVNYVTSEAKNVIETFESWGFEFEEDLRLEGGHTKRRVLHRTDETGREIFN 123 Query: 157 IYQNNLTKSHIEIIRG---HAAFTSDPKPTIEVS--GKKYTAPHILIATGGMPSTPHESQ 211 + I II G +++ATGG S Sbjct: 124 FLLKLAREEGIPIIEDRLVEIRVKDGKVTGFVTEKRGLVEDVDKLVLATGGYSYLYEYSS 183 Query: 212 IPGASLGITSDGFFQLEELPGRSVIVGAGYI--AVEMAGI---LSALGSKTSLM------ 260 ++G F+ AG I +E +++L + L+ Sbjct: 184 TQSTNIGDGMAIAFK------------AGTILADMEFVQFHPTVTSLDGEVFLLTETLRG 231 Query: 261 -------IRHDKVLRSFDS--------MISTNCTEELENAGVEVLKFSQVKEVKKTLSGL 305 ++ L ++D ++S E+ + S++++ ++ + Sbjct: 232 EGAQIINENGERFLFNYDKRGELAPRDILSRAIYIEMLKGHKVFIDLSKIEDFERKFPVV 291 Query: 306 EVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNT 365 + + + P + G I V+ + Sbjct: 292 AKYLARHGHNYKVKIPIFPAAHFV------------------------DGGIRVNIRGES 327 Query: 366 NVKGIYAVGDVCG 378 N+ +YA+G+V Sbjct: 328 NIVNLYAIGEVSD 340 >3MJ4-A nrPDB Length = 397 Score = 41.1 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 28/142 (19%), Positives = 46/142 (32%), Gaps = 17/142 (11%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKKVMWNTAVHSEFM 123 +DYL++G G G A R A G R +V+ +GG C + Sbjct: 30 FDYLIVGAGFAGSVLAERLASSGQRVLIVDRRPHIGGNAY--DCYDDAGVLIHPYGPHIF 87 Query: 124 HDHADYGFPSCEGKFNWRVIKEKRDAYVSR-----------LNAIYQNNLTKSHIEIIRG 172 H ++ F WR + + A V +N +Y NLT +E Sbjct: 88 HTNSKDVFEYLSRFTEWRPYQHRVLASVDGQLLPIPINLDTVNRLYGLNLTSFQVEEFFA 147 Query: 173 HAAFTSDPKPTIEVSGKKYTAP 194 ++ + S + Sbjct: 148 S---VAEKVEQVRTSEDVVVSK 166 Score = 30.7 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 9/32 (28%), Positives = 18/32 (56%) Query: 235 VIVGAGYIAVEMAGILSALGSKTSLMIRHDKV 266 +IVGAG+ +A L++ G + ++ R + Sbjct: 33 LIVGAGFAGSVLAERLASSGQRVLIVDRRPHI 64 >3NK2-X nrPDB Length = 431 Score = 41.1 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 1/38 (2%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGG 100 YD +V+GGG GL +AR G + ++E + LGG Sbjct: 1 MYDAIVVGGGFSGLKAARDLTNAGKKVLLLEGGERLGG 38 Score = 33.7 bits (76), Expect = 0.22, Method: Composition-based stats. Identities = 8/32 (25%), Positives = 18/32 (56%) Query: 235 VIVGAGYIAVEMAGILSALGSKTSLMIRHDKV 266 ++VG G+ ++ A L+ G K L+ +++ Sbjct: 5 IVVGGGFSGLKAARDLTNAGKKVLLLEGGERL 36 >1F8S-A nrPDB Length = 498 Score = 40.7 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 19/36 (52%) Query: 231 PGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKV 266 P VIVGAG + A +L+ G + +++ ++ Sbjct: 33 PKHVVIVGAGMAGLSAAYVLAGAGHQVTVLEASERP 68 Score = 35.7 bits (81), Expect = 0.047, Method: Composition-based stats. Identities = 11/35 (31%), Positives = 20/35 (57%), Gaps = 1/35 (2%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVES-HKLGG 100 +++G G GL++A A G + V+E+ + GG Sbjct: 36 VVIVGAGMAGLSAAYVLAGAGHQVTVLEASERPGG 70 >3WE0-A nrPDB Length = 580 Score = 39.9 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 17/53 (32%), Positives = 25/53 (47%), Gaps = 2/53 (3%) Query: 48 QEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGG 100 + P G PAA ++G G GL +A +LG + V E+ K+GG Sbjct: 51 EHPAGLGSIPAARHGEE--VAIVGAGIAGLVAAYELMKLGLKPVVYEASKMGG 101 >4B68-A nrPDB Length = 501 Score = 39.9 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 26/130 (20%), Positives = 44/130 (33%), Gaps = 21/130 (16%) Query: 167 IEIIRGHAAFTSDPKPTIEVSGKKYTA--------PHILIATGGMPSTPHESQ-----IP 213 +E+I G + +S V + ++IA GG P I Sbjct: 169 VEVIPGKSDPSSSVVDFFTVRSRNVETGEISARRTRKVVIAIGGTAKMPSGLPQDPRIIH 228 Query: 214 GASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSAL-----GSKTSLMIRHDKVLR 268 + T + + P ++G+G A E I L S+T+L++R + Sbjct: 229 SSKYCTTLPALLKDKSKPYNIAVLGSGQSAAE---IFHDLQKRYPNSRTTLIMRDSAMRP 285 Query: 269 SFDSMISTNC 278 S DS Sbjct: 286 SDDSPFVNEI 295 >6C6P-A nrPDB Length = 458 Score = 39.5 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 14/97 (14%), Positives = 37/97 (38%), Gaps = 3/97 (3%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF 292 +IVGAG + +A +LS G K +++ R L+ D ++ + ++ Sbjct: 9 EVIIVGAGVLGSALAAVLSRDGRKVTVIERD---LKEPDRIVGEFLQPGGYHVLKDLGLG 65 Query: 293 SQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCL 329 V+ + + + + + + + + + Sbjct: 66 DTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQV 102 Score = 29.9 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 8/39 (20%), Positives = 16/39 (41%) Query: 58 AAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESH 96 + + +++G G G A A + G + V+E Sbjct: 1 GTSSQNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERD 39 >5L46-A nrPDB Length = 841 Score = 39.1 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 24/120 (20%), Positives = 48/120 (40%), Gaps = 20/120 (16%) Query: 44 MACRQEPQPQGPPPAAGAVAS-YDYLVIGGGSGGLASARRAAELGAR-AAVVESHKL--G 99 M C +E + + P A + ++IGGG G++ A A+ G + ++E +L G Sbjct: 1 MVCGREGEEKPPLSAETQWKDRAETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAG 60 Query: 100 GTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQ 159 T W+ A + + H G + ++ + EK + ++ +Q Sbjct: 61 ST------------WHAAGLTTYFHP----GINLKKIHYDSIKLYEKLEEETGQVVGFHQ 104 Score = 29.5 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 19/97 (19%), Positives = 38/97 (39%), Gaps = 4/97 (4%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF 292 +VI+G G + V +A L+ G K +++ ++ + T + G+ + K Sbjct: 24 ETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTT--YFHPGINLKKI 81 Query: 293 S--QVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVD 327 +K +K + PG + + T VD Sbjct: 82 HYDSIKLYEKLEEETGQVVGFHQPGSIRLATTPVRVD 118 >6BRD-A nrPDB Length = 476 Score = 39.1 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 12/32 (37%), Positives = 16/32 (50%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVES 95 +D +V+GGG GL A G R V+E Sbjct: 1 MFDVIVVGGGPTGLMLAGELRLHGVRVLVLEK 32 Score = 28.7 bits (63), Expect = 6.4, Method: Composition-based stats. Identities = 10/56 (17%), Positives = 23/56 (41%), Gaps = 1/56 (1%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSM-ISTNCTEELENAGV 287 ++VG G + +AG L G + ++ + + R + + E + G+ Sbjct: 3 DVIVVGGGPTGLMLAGELRLHGVRVLVLEKETEPTRQSRAQGLHVRSIEVMAQRGL 58 >3IHG-A nrPDB Length = 535 Score = 38.8 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 15/33 (45%), Positives = 18/33 (54%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESH 96 D LV+G G GGL++A A G R VVE Sbjct: 5 EVDVLVVGAGLGGLSTAMFLARQGVRVLVVERR 37 Score = 36.8 bits (84), Expect = 0.024, Method: Composition-based stats. Identities = 16/103 (15%), Positives = 37/103 (35%) Query: 227 LEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAG 286 + + ++VGAG + A L+ G + ++ R + + T EL G Sbjct: 1 MNDHEVDVLVVGAGLGGLSTAMFLARQGVRVLVVERRPGLSPYPRAAGQNPRTMELLRIG 60 Query: 287 VEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCL 329 + + +++ T + + +V G + D + Sbjct: 61 GVADEVVRADDIRGTQGDFVIRLAESVRGEILRTVSESFDDMV 103 >1C0L-A nrPDB Length = 363 Score = 38.4 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 10/31 (32%), Positives = 17/31 (54%) Query: 232 GRSVIVGAGYIAVEMAGILSALGSKTSLMIR 262 R V++G+G I + A IL+ G ++ R Sbjct: 7 KRVVVLGSGVIGLSSALILARKGYSVHILAR 37 >4A6N-B nrPDB Length = 398 Score = 38.4 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 15/60 (25%), Positives = 27/60 (45%), Gaps = 4/60 (6%) Query: 232 GRSVIVGAGYIAVEMAGILSALGSKTSLMIR-HDKVLRSFDSMI---STNCTEELENAGV 287 I+G G + + MA +L G S+ R +D+ R F + + E ++ AG+ Sbjct: 27 KNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGGTLDLHKGSGQEAMKKAGL 86 Score = 38.0 bits (87), Expect = 0.011, Method: Composition-based stats. Identities = 35/158 (22%), Positives = 57/158 (36%), Gaps = 18/158 (11%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVESHK------LGGTC-VNVGCVPKKVMWNTAV 118 + +IGGG GL A+ + G +V E GGT ++ G ++ M + Sbjct: 28 NVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGGTLDLHKGSG-QEAMKKAGL 86 Query: 119 HSEFMHDHADYGFPSCEGKFNWRVIKEKR------DAYVSR--LNAIYQNNLTKSHIEII 170 + G + K N K + + ++R L AI N+L + Sbjct: 87 LQTYYDLALPMGVNIADEKGNILSTKNVKPENRFDNPEINRNDLRAILLNSLENDTVIWD 146 Query: 171 RGHAAFT-SDPKPTIEVSGKKY-TAPHILIATGGMPST 206 R K T+ K TA +++A GGM Sbjct: 147 RKLVMLEPGKKKWTLTFENKPSETADLVILANGGMSKV 184 >2DKH-A nrPDB Length = 639 Score = 38.4 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 14/49 (28%), Positives = 21/49 (42%), Gaps = 1/49 (2%) Query: 50 PQPQGPPPAAGAVASYDYLVIGGGSGGLA-SARRAAELGARAAVVESHK 97 P P + D L++G G GL +A+ AA R +VE + Sbjct: 18 ASPLAPAHTEAVPSQVDVLIVGCGPAGLTLAAQLAAFPDIRTCIVEQKE 66 >2GAG-A nrPDB Length = 965 Score = 38.0 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 55/296 (18%), Positives = 95/296 (32%), Gaps = 36/296 (12%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVV-ESHKLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 D LV+G G GLA+AR A+ GAR ++ E + GGT ++ + M Sbjct: 130 DVLVVGAGPAGLAAAREASRSGARVMLLDERAEAGGT----------LLDTAGEQIDGMD 179 Query: 125 DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTI 184 A + E +R +A Y + + P Sbjct: 180 SSAWIEQVTSELAEAEETTHLQRTTVFGSYDANYLIAAQRRTV--------HLDGPSGPG 231 Query: 185 EVSGK--KYTAPHILIATGG--MPSTPHESQIPGASLGITSDGFFQLEELP--GRSVIVG 238 + A +++ATG P + PG L + + R + Sbjct: 232 VSRERIWHIRAKQVVLATGAHERPIVFENNDRPGIMLAGAVRSYLNRYGVRAGARIAVAT 291 Query: 239 AGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEV 298 A E+ L+A G +++ + + GV+V+ S V + Sbjct: 292 TNDSAYELVRELAATGGVVAVIDA---------RSSISAAAAQAVADGVQVISGSVVVDT 342 Query: 299 KKTLSGLEVSMVTAVPGRLPVM--TMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD 352 + +G ++V A + T + D L A G P S + + D Sbjct: 343 EADENGELSAIVVAELDEARELGGTQRFEADVLAVAGGFNPVVHLHSQRQGKLDWD 398 >3UKH-A nrPDB Length = 519 Score = 38.0 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 16/41 (39%), Positives = 24/41 (58%), Gaps = 2/41 (4%) Query: 62 VASYDYLVIGGGSGGLASARRAAEL-GARAAVVESHK-LGG 100 S D LVIG G GL +A+R ++ G +V+S++ GG Sbjct: 4 DISVDVLVIGAGPTGLGAAKRLNQIDGPSWMIVDSNETPGG 44 >2VHY-A nrPDB Length = 377 Score = 38.0 bits (87), Expect = 0.011, Method: Composition-based stats. Identities = 13/37 (35%), Positives = 19/37 (51%) Query: 58 AAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVE 94 V D +VIG G+ G +AR A +GA V++ Sbjct: 162 GVPGVEPADVVVIGAGTAGYNAARIANGMGATVTVLD 198 Score = 33.0 bits (74), Expect = 0.34, Method: Composition-based stats. Identities = 11/52 (21%), Positives = 21/52 (40%) Query: 231 PGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEEL 282 P V++GAG A I + +G+ +++ + LR D+ Sbjct: 168 PADVVVIGAGTAGYNAARIANGMGATVTVLDINIDKLRQLDAEFCGRIHTRY 219 >4C3X-A nrPDB Length = 530 Score = 38.0 bits (87), Expect = 0.011, Method: Composition-based stats. Identities = 17/42 (40%), Positives = 20/42 (47%), Gaps = 1/42 (2%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVES-HKLGGTCVNVG 106 D LV+G G G L A AA G V+E + GGT G Sbjct: 29 DVLVVGSGGGALTGAYTAAAQGLTTIVLEKTDRFGGTSAYSG 70 >4H7U-A nrPDB Length = 602 Score = 38.0 bits (87), Expect = 0.011, Method: Composition-based stats. Identities = 22/73 (30%), Positives = 34/73 (46%), Gaps = 5/73 (6%) Query: 29 LLPEPAAL-TRALSRAMACRQEPQ---PQGPPPAAGAVASYDYLVIGGGSGGLASARRAA 84 +LP L +R LS A+ Q + P + YD++V GGG+ GL A R + Sbjct: 1 MLPRVTKLNSRLLSLALLGIQIARGAITYQHPDDLPSGVDYDFIVAGGGTAGLVVASRLS 60 Query: 85 EL-GARAAVVESH 96 E + V+E+ Sbjct: 61 ENSNWKVLVIEAG 73 >4DGK-A nrPDB Length = 501 Score = 37.6 bits (86), Expect = 0.012, Method: Composition-based stats. Identities = 15/33 (45%), Positives = 17/33 (51%), Gaps = 1/33 (3%) Query: 69 VIGGGSGGLASARRAAELGARAAVVE-SHKLGG 100 VIG G GGLA A R G ++E K GG Sbjct: 6 VIGAGFGGLALAIRLQAAGIPVLLLEQRDKPGG 38 Score = 31.4 bits (70), Expect = 0.85, Method: Composition-based stats. Identities = 10/35 (28%), Positives = 18/35 (51%) Query: 232 GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKV 266 + ++GAG+ + +A L A G L+ + DK Sbjct: 2 KPTTVIGAGFGGLALAIRLQAAGIPVLLLEQRDKP 36 >1QO8-A nrPDB Length = 566 Score = 37.2 bits (85), Expect = 0.016, Method: Composition-based stats. Identities = 14/43 (32%), Positives = 21/43 (48%) Query: 58 AAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGG 100 AAG + LV+G GS G ++ A + GA +V+ G Sbjct: 115 AAGPSETTQVLVVGAGSAGFNASLAAKKAGANVILVDKAPFSG 157 >1SEZ-A nrPDB Length = 504 Score = 37.2 bits (85), Expect = 0.018, Method: Composition-based stats. Identities = 14/35 (40%), Positives = 17/35 (48%), Gaps = 1/35 (2%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVES-HKLGG 100 VIG G GLA+A + G V E+ K GG Sbjct: 16 VAVIGAGVSGLAAAYKLKIHGLNVTVFEAEGKAGG 50 Score = 33.7 bits (76), Expect = 0.17, Method: Composition-based stats. Identities = 7/30 (23%), Positives = 12/30 (40%) Query: 232 GRSVIVGAGYIAVEMAGILSALGSKTSLMI 261 R ++GAG + A L G ++ Sbjct: 14 KRVAVIGAGVSGLAAAYKLKIHGLNVTVFE 43 >4K2X-A nrPDB Length = 523 Score = 37.2 bits (85), Expect = 0.020, Method: Composition-based stats. Identities = 13/36 (36%), Positives = 17/36 (47%) Query: 60 GAVASYDYLVIGGGSGGLASARRAAELGARAAVVES 95 G+ YD ++ G G GL A GAR V+E Sbjct: 18 GSHMRYDVVIAGAGPTGLMLACELRLAGARTLVLER 53 >1FOH-A nrPDB Length = 664 Score = 36.8 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 9/36 (25%), Positives = 17/36 (47%), Gaps = 5/36 (13%) Query: 66 DYLVIGGGSGGLASARRAAEL-----GARAAVVESH 96 D L++G G GL +AR +E + +++ Sbjct: 9 DVLIVGAGPAGLMAARVLSEYVRQKPDLKVRIIDKR 44 >5KXJ-A nrPDB Length = 557 Score = 36.8 bits (84), Expect = 0.021, Method: Composition-based stats. Identities = 16/60 (26%), Positives = 32/60 (53%), Gaps = 1/60 (1%) Query: 355 GHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTV 414 G ++VD++ T+V G+YA+G+V L +A+ L ++ + +D +P+V Sbjct: 355 GGVVVDDYGRTDVDGLYAIGEVSYTGLHGANRMASNSLLECLVYGWSAAMDID-RRMPSV 413 Score = 33.7 bits (76), Expect = 0.20, Method: Composition-based stats. Identities = 12/33 (36%), Positives = 18/33 (54%), Gaps = 1/33 (3%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVESHKL 98 D L+IG G+ GL+ A R AE + V+ + Sbjct: 10 DVLIIGSGAAGLSLALRLAE-KHKVIVLSKGPV 41 >3CP8-A nrPDB Length = 641 Score = 36.8 bits (84), Expect = 0.024, Method: Composition-based stats. Identities = 9/30 (30%), Positives = 14/30 (46%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVV 93 YD +V+G G G +A A G ++ Sbjct: 21 MYDVIVVGAGHAGCEAALAVARGGLHCLLI 50 >4Z2R-A nrPDB Length = 592 Score = 36.4 bits (83), Expect = 0.027, Method: Composition-based stats. Identities = 11/32 (34%), Positives = 17/32 (53%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVESHK 97 D L++G G G SA A LG R+ ++ + Sbjct: 14 DVLIVGAGPAGAMSATLLASLGIRSLMINRWR 45 >6H3G-A nrPDB Length = 651 Score = 36.4 bits (83), Expect = 0.028, Method: Composition-based stats. Identities = 11/40 (27%), Positives = 15/40 (37%), Gaps = 2/40 (5%) Query: 60 GAVASYDYLVIGGGSGGLASARRAAELG--ARAAVVESHK 97 G D +V GGG G A R A + ++E Sbjct: 2 GHPEEVDVIVCGGGPAGCVVAGRLAYADPTLKVMLIEGGA 41 >5X6R-A nrPDB Length = 420 Score = 36.4 bits (83), Expect = 0.030, Method: Composition-based stats. Identities = 20/104 (19%), Positives = 36/104 (34%), Gaps = 8/104 (7%) Query: 201 GGMPSTPHESQIPGASLGITSDGFFQLE-ELPGRSVIVGAGYIAVEMAGILSALGSKTSL 259 G H+ IP T++ + + + I+GAG + A S G +L Sbjct: 3 GSHHHHHHDYDIP------TTENLYYFQGSMSESVAIIGAGLVGCLAALAFSKEGYNVTL 56 Query: 260 MI-RHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTL 302 R D L + + + + G++ LK + L Sbjct: 57 YDFRQDPRLDTTKNKNLKSINLAISARGIDALKSIDPDACEHIL 100 >3KYB-A nrPDB Length = 390 Score = 36.4 bits (83), Expect = 0.031, Method: Composition-based stats. Identities = 8/35 (22%), Positives = 18/35 (51%) Query: 232 GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKV 266 + +IVGAG+ + L+ G + ++ + D + Sbjct: 4 KKILIVGAGFSGAVIGRQLAEKGHQVHIIDQRDHI 38 >3FPZ-A nrPDB Length = 326 Score = 36.1 bits (82), Expect = 0.036, Method: Composition-based stats. Identities = 12/38 (31%), Positives = 21/38 (55%), Gaps = 3/38 (7%) Query: 66 DYLVIGGGSGGLASARRAAEL--GARAAVVESH-KLGG 100 D +++G GS GL++A A+ + ++ES GG Sbjct: 67 DVIIVGAGSSGLSAAYVIAKNRPDLKVCIIESSVAPGG 104 >4MO2-B nrPDB Length = 368 Score = 36.1 bits (82), Expect = 0.037, Method: Composition-based stats. Identities = 17/40 (42%), Positives = 21/40 (52%), Gaps = 1/40 (2%) Query: 64 SYDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTC 102 YDYL++G G G A A E G VVE + +GG C Sbjct: 1 MYDYLIVGSGLFGSIFAYEATEKGYTCLVVEQREHIGGNC 40 >1RP0-A nrPDB Length = 284 Score = 36.1 bits (82), Expect = 0.040, Method: Composition-based stats. Identities = 12/37 (32%), Positives = 21/37 (56%), Gaps = 2/37 (5%) Query: 66 DYLVIGGGSGGLASARRAAEL-GARAAVVESH-KLGG 100 D +V+G GS GL++A ++ + A++E GG Sbjct: 41 DVVVVGAGSAGLSAAYEISKNPNVQVAIIEQSVSPGG 77 >4YNU-A nrPDB Length = 571 Score = 35.7 bits (81), Expect = 0.045, Method: Composition-based stats. Identities = 13/36 (36%), Positives = 21/36 (58%), Gaps = 1/36 (2%) Query: 63 ASYDYLVIGGGSGGLASARRAAEL-GARAAVVESHK 97 +YDY+V+GGG+ GL A R +E ++E+ Sbjct: 4 TTYDYIVVGGGTSGLVVANRLSENPDVSVLLLEAGA 39 >4P9S-A nrPDB Length = 848 Score = 35.7 bits (81), Expect = 0.048, Method: Composition-based stats. Identities = 23/115 (20%), Positives = 46/115 (40%), Gaps = 20/115 (17%) Query: 48 QEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGAR-AAVVESHKL--GGTCVN 104 +E Q P P + + ++IGGG G++ A A+ G R ++E +L G T Sbjct: 8 REGQESPPSPPEWKDRA-ETVIIGGGCVGVSLAYHLAKAGMRDVVLLEKSELTAGST--- 63 Query: 105 VGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQ 159 W+ A + + H G + ++ + E+ + ++ +Q Sbjct: 64 ---------WHAAGLTTYFHP----GINLKKIHYDSIKLYERLEEETGQVVGFHQ 105 Score = 28.4 bits (62), Expect = 7.5, Method: Composition-based stats. Identities = 9/33 (27%), Positives = 17/33 (51%), Gaps = 1/33 (3%) Query: 233 RSVIVGAGYIAVEMAGILSALGS-KTSLMIRHD 264 +VI+G G + V +A L+ G L+ + + Sbjct: 25 ETVIIGGGCVGVSLAYHLAKAGMRDVVLLEKSE 57 >3HDH-A nrPDB Length = 302 Score = 35.7 bits (81), Expect = 0.048, Method: Composition-based stats. Identities = 14/104 (13%), Positives = 37/104 (35%), Gaps = 9/104 (8%) Query: 230 LPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEV 289 L ++G G + +A + +A G L+ + + +L I + + + Sbjct: 14 LVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKK----- 68 Query: 290 LKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAI 333 + E K ++++ +++ D ++ AI Sbjct: 69 ----KFAENPKAGDEFVEKTLSSISTSTDAASVVHSTDLVVEAI 108 >5EZ7-A nrPDB Length = 392 Score = 35.7 bits (81), Expect = 0.050, Method: Composition-based stats. Identities = 15/35 (42%), Positives = 18/35 (51%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVESHKLGG 100 D L++GGG GL R G +VES LGG Sbjct: 9 DILIVGGGIAGLWLNARLRRAGYATVLVESASLGG 43 >3JSK-A nrPDB Length = 344 Score = 35.7 bits (81), Expect = 0.050, Method: Composition-based stats. Identities = 20/64 (31%), Positives = 29/64 (45%), Gaps = 10/64 (15%) Query: 40 LSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAEL--GARAAVVESH- 96 +SRAM R A A D +++G GS GL++A + L R +VE+ Sbjct: 62 VSRAMTRRYFAD-------LDAHAETDIVIVGAGSCGLSAAYVLSTLRPDLRITIVEAGV 114 Query: 97 KLGG 100 GG Sbjct: 115 APGG 118 >2GAG-B nrPDB Length = 405 Score = 35.7 bits (81), Expect = 0.054, Method: Composition-based stats. Identities = 20/59 (33%), Positives = 30/59 (50%), Gaps = 4/59 (6%) Query: 63 ASYDYLVIGGGSGGLASARRAAE-LGA-RAAVVESHKL-GGTCV-NVGCVPKKVMWNTA 117 SYD +++GGG GLA+A A+ G AV+E L GG N + +W+ + Sbjct: 20 KSYDAIIVGGGGHGLATAYFLAKNHGITNVAVLEKGWLAGGNMARNTTIIRSNYLWDES 78 >3COX-A nrPDB Length = 507 Score = 35.7 bits (81), Expect = 0.057, Method: Composition-based stats. Identities = 56/322 (17%), Positives = 94/322 (29%), Gaps = 85/322 (26%) Query: 68 LVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCV------PKK-VMWNTAVHS 120 LVIG G GG +A R + G +VE + T + G + P K MW Sbjct: 15 LVIGSGYGGAVAALRLTQAGIPTQIVEMGRSWDTPGSDGKIFCGMLNPDKRSMWLADKTD 74 Query: 121 EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP 180 + + + +G D YV ++ S I++ +G Sbjct: 75 QPVSNFMGFGINKS------------IDRYV-----GVLDSERFSGIKVYQGRG------ 111 Query: 181 KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG 240 V G + GGM TP + + S+ + P + G G Sbjct: 112 -----VGGGS-------LVNGGMAVTPKRNYFEEILPSVDSNEM-YNKYFPRANT--GLG 156 Query: 241 YIAVEMAGI-------LSALGSK-------TSLMIRHDKVLRSFDSMISTNCTE------ 280 ++ A + G K T+ + + + T+ Sbjct: 157 VNNIDQAWFESTEWYKFARTGRKTAQRSGFTTAFVPNVYDFEYMKKEAAGQVTKSGLGGE 216 Query: 281 -------------------ELENAGVEVLKFSQVKEV-KKTLSGLEVSMVTAVPGRLPVM 320 + + +V +V T SG V+M V Sbjct: 217 VIYGNNAGKKSLDKTYLAQAAATGKLTITTLHRVTKVAPATGSGYSVTMEQIDEQGNVVA 276 Query: 321 TMIPDVDCLLWAIGRVPNTKDL 342 T + D + +A G V +K L Sbjct: 277 TKVVTADRVFFAAGSVGTSKLL 298 >5MOG-A nrPDB Length = 497 Score = 35.3 bits (80), Expect = 0.067, Method: Composition-based stats. Identities = 15/55 (27%), Positives = 24/55 (43%), Gaps = 10/55 (18%) Query: 47 RQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVE-SHKLGG 100 R QP P ++ G G GL++A+ A+ G + ++E LGG Sbjct: 9 RNSEQPTKPLQ---------VVIAGAGLAGLSTAKYLADAGHKPILLEARDVLGG 54 Score = 32.6 bits (73), Expect = 0.43, Method: Composition-based stats. Identities = 15/44 (34%), Positives = 20/44 (45%), Gaps = 3/44 (6%) Query: 224 FFQLEELPGR---SVIVGAGYIAVEMAGILSALGSKTSLMIRHD 264 FF+ E P + VI GAG + A L+ G K L+ D Sbjct: 7 FFRNSEQPTKPLQVVIAGAGLAGLSTAKYLADAGHKPILLEARD 50 >4EIQ-A nrPDB Length = 549 Score = 34.9 bits (79), Expect = 0.084, Method: Composition-based stats. Identities = 12/37 (32%), Positives = 17/37 (45%) Query: 60 GAVASYDYLVIGGGSGGLASARRAAELGARAAVVESH 96 A D L++GGG G+A A A VV++ Sbjct: 22 NAPIETDVLILGGGPVGMALALDLAHRQVGHLVVDAG 58 >1F14-A nrPDB Length = 310 Score = 34.9 bits (79), Expect = 0.086, Method: Composition-based stats. Identities = 13/102 (12%), Positives = 35/102 (34%), Gaps = 9/102 (8%) Query: 232 GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLK 291 ++G G + +A + +A G L+ + + +L I + + + Sbjct: 16 KHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKK------- 68 Query: 292 FSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAI 333 + E K ++ + +++ D ++ AI Sbjct: 69 --KFAENPKAGDECVEKTLSTIATSTDAASVVHSTDLVVEAI 108 >1GPE-A nrPDB Length = 587 Score = 34.9 bits (79), Expect = 0.093, Method: Composition-based stats. Identities = 14/41 (34%), Positives = 21/41 (51%), Gaps = 1/41 (2%) Query: 57 PAAGAVASYDYLVIGGGSGGLASARRAAEL-GARAAVVESH 96 P+ A +YDY++ GGG GL A + E + V+E Sbjct: 17 PSKVAGKTYDYIIAGGGLTGLTVAAKLTENPKIKVLVIEKG 57 >4RPJ-A nrPDB Length = 399 Score = 34.9 bits (79), Expect = 0.099, Method: Composition-based stats. Identities = 16/40 (40%), Positives = 21/40 (52%), Gaps = 2/40 (5%) Query: 63 ASYDYLVIGGGSGGLASARR-AAELGARAAVVESHK-LGG 100 A +D V+G G GL A R A +L R V+E +GG Sbjct: 6 ARFDLFVVGSGFFGLTIAERVATQLDKRVLVLERRPHIGG 45 >5EB4-A nrPDB Length = 532 Score = 34.5 bits (78), Expect = 0.10, Method: Composition-based stats. Identities = 13/38 (34%), Positives = 21/38 (55%), Gaps = 1/38 (2%) Query: 61 AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKL 98 + SYDY+VIGGG+ G A +E + ++E + Sbjct: 23 SEGSYDYIVIGGGTSGCPLAATLSE-KYKVLLLERGTI 59 >5KOX-A nrPDB Length = 476 Score = 34.5 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 11/30 (36%), Positives = 14/30 (46%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVES 95 D ++ GGG GL A G R V+E Sbjct: 6 DVIIAGGGPTGLMLAGELRLHGVRTVVLEK 35 >6ACQ-A nrPDB Length = 302 Score = 34.5 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 19/101 (18%), Positives = 41/101 (40%), Gaps = 15/101 (14%) Query: 232 GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLK 291 + ++GAG + +A +A G + VLR + + +++K Sbjct: 22 KKVCVIGAGTMGSGIAQAFAAKGFEV--------VLRDIKDEFVDRGLDFINKNLSKLVK 73 Query: 292 FSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWA 332 +++E K V ++T + G + + M D D ++ A Sbjct: 74 KGKIEEATK------VEILTRISGTV-DLNMAADCDLVIEA 107 >4N9X-A nrPDB Length = 411 Score = 34.5 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 14/36 (38%), Positives = 19/36 (52%) Query: 62 VASYDYLVIGGGSGGLASARRAAELGARAAVVESHK 97 + S+D ++ GGG GLA A G R AV+E Sbjct: 1 MQSFDVVIAGGGMVGLALACGLQGSGLRIAVLEKQA 36 >3OZ2-A nrPDB Length = 397 Score = 34.5 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 13/51 (25%), Positives = 21/51 (41%) Query: 78 ASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHAD 128 +AR AA+ G + ++E G+ V G K + N A A+ Sbjct: 18 TAARYAAKYGLKTLMIEKRPEIGSPVRCGEGLSKGILNEADIKADRSFIAN 68 >5AYV-A nrPDB Length = 309 Score = 34.5 bits (78), Expect = 0.13, Method: Composition-based stats. Identities = 10/34 (29%), Positives = 19/34 (55%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKV 266 R ++GAG I +L+ G+ +L+ R ++V Sbjct: 2 RIYVLGAGSIGSLFGALLARAGNDVTLIGRREQV 35 >1XDU-A nrPDB Length = 374 Score = 34.1 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 22/76 (28%), Positives = 32/76 (42%) Query: 19 AARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLA 78 A R R F L AL + M+C ++ + P A A L +GGG+GG+ Sbjct: 138 AGRYGRPFWEDLSADVALADSFDALMSCDEDLAYEAPADAYDWSAVRHVLDVGGGNGGML 197 Query: 79 SARRAAELGARAAVVE 94 +A R +VE Sbjct: 198 AAIALRAPHLRGTLVE 213 >3GDN-A nrPDB Length = 521 Score = 34.1 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 15/43 (34%), Positives = 22/43 (51%), Gaps = 1/43 (2%) Query: 63 ASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNV 105 SYDY+++GGG+ G A +E + V+E L NV Sbjct: 25 GSYDYVIVGGGTSGCPLAATLSE-KYKVLVLERGSLPTAYPNV 66 >1KNR-A nrPDB Length = 540 Score = 34.1 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 10/22 (45%), Positives = 18/22 (81%) Query: 355 GHIIVDEFQNTNVKGIYAVGDV 376 G ++VD+ T+V+G+YA+G+V Sbjct: 355 GGVMVDDHGRTDVEGLYAIGEV 376 Score = 32.2 bits (72), Expect = 0.54, Method: Composition-based stats. Identities = 10/19 (52%), Positives = 13/19 (68%) Query: 66 DYLVIGGGSGGLASARRAA 84 D L+IG G+ GL+ A R A Sbjct: 10 DVLIIGSGAAGLSLALRLA 28 >5OWF-A nrPDB Length = 259 Score = 34.1 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 23/90 (25%), Positives = 35/90 (38%), Gaps = 1/90 (1%) Query: 130 GFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGK 189 GF G + ++ K S +A+ + L I+ I + T + I S K Sbjct: 49 GFDIDLGNEMCKRMQVKCTWVASDFDALIPS-LKAKKIDAIISSLSITDKRQQEIAFSDK 107 Query: 190 KYTAPHILIATGGMPSTPHESQIPGASLGI 219 Y A LIA G P P + G +G+ Sbjct: 108 LYAADSRLIAAKGSPIQPTLESLKGKHVGV 137 >6HRD-A nrPDB Length = 317 Score = 34.1 bits (77), Expect = 0.15, Method: Composition-based stats. Identities = 9/56 (16%), Positives = 24/56 (42%) Query: 232 GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGV 287 R +VGAG + +A + + G + ++ + ++ + + I + + V Sbjct: 26 QRVGVVGAGQMGSGIAEVSARAGVEVTVFEPAEALITAGRNRIVKSLERAVSAGKV 81 >2XVH-A nrPDB Length = 464 Score = 34.1 bits (77), Expect = 0.15, Method: Composition-based stats. Identities = 40/226 (17%), Positives = 70/226 (30%), Gaps = 44/226 (19%) Query: 67 YLVIGGGSGGLAS--ARRAAEL-GARA---AVVESHK-LGGTCVNV---GCVPKKVMWNT 116 ++G G G+A A ++A+ GA E GG G ++ Sbjct: 5 IAILGAGPSGMAQLRAFQSAQEKGAEIPELVCFEKQADWGGQWNYTWRTGLDENGEPVHS 64 Query: 117 AVHSEFMH-------DHADYGFPSCEGK---------FNWRVIKEKRDAYVSRLNAIYQN 160 +++ + ADY F GK W IK + + + + Sbjct: 65 SMYRYLWSNGPKECLEFADYTFDEHFGKPIASYPPREVLWDYIKGRVEKA--GVRKYIRF 122 Query: 161 NLTKSHIEIIRGHAAFT----SDPKPTIEVSGKKYTAPHILIATG--GMPSTPHESQIP- 213 N H+E FT TI +++ TG P P Sbjct: 123 NTAVRHVEFNEDSQTFTVTVQDHTTDTIYSE----EFDYVVCCTGHFSTPYVPEFEGFEK 178 Query: 214 -GASLGITSD--GFFQLEELPGRSVIVGAGYIAVEMAGILSALGSK 256 G + D + ++ ++VG+ Y A ++ G+K Sbjct: 179 FGGRILHAHDFRDALEFKD--KTVLLVGSSYSAEDIGSQCYKYGAK 222 >5I68-A nrPDB Length = 663 Score = 33.7 bits (76), Expect = 0.19, Method: Composition-based stats. Identities = 13/38 (34%), Positives = 20/38 (52%), Gaps = 2/38 (5%) Query: 62 VASYDYLVIGGGSGGLASARRAAELG--ARAAVVESHK 97 +D LV+GGGS G A R A L + ++E+ + Sbjct: 4 PEEFDILVLGGGSSGSCIAGRLANLDHSLKVGLIEAGE 41 >4UDQ-A nrPDB Length = 531 Score = 33.7 bits (76), Expect = 0.21, Method: Composition-based stats. Identities = 11/33 (33%), Positives = 19/33 (57%), Gaps = 1/33 (3%) Query: 65 YDYLVIGGGSGGLASARRA-AELGARAAVVESH 96 +DY+++GGG+ G A R A R ++E+ Sbjct: 6 FDYVIVGGGTAGSVLANRLSARPENRVLLIEAG 38 >5Y77-A nrPDB Length = 473 Score = 33.7 bits (76), Expect = 0.21, Method: Composition-based stats. Identities = 21/104 (20%), Positives = 39/104 (37%), Gaps = 2/104 (1%) Query: 234 SVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFS 293 I+GAG +A +L+ G + +L R R + L G L+ + Sbjct: 11 VTIIGAGLAGTLVARLLARNGWQVNLFERRPDP-RIETGARGRSINLALAERGAHALRLA 69 Query: 294 QVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDC-LLWAIGRV 336 ++ + + + VPG P + D ++W+I R Sbjct: 70 GLEREVLAEAVMMRGRMVHVPGTPPNLQPYGRDDSEVIWSINRD 113 Score = 31.8 bits (71), Expect = 0.82, Method: Composition-based stats. Identities = 9/30 (30%), Positives = 12/30 (40%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESH 96 +IG G G AR A G + + E Sbjct: 11 VTIIGAGLAGTLVARLLARNGWQVNLFERR 40 >3Q9T-A nrPDB Length = 577 Score = 33.4 bits (75), Expect = 0.24, Method: Composition-based stats. Identities = 33/178 (18%), Positives = 63/178 (35%), Gaps = 32/178 (17%) Query: 64 SYDYLVIGGGSGGLASARRAAEL-GARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEF 122 +D++++GGG+ G A R AE +VE+ +G N +P+ + + + Sbjct: 6 HFDFVIVGGGTAGNTVAGRLAENPNVTVLIVEAG-IG----NPEDIPE--ITTPSSAMDL 58 Query: 123 MHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKP 182 + D+ + + + + EK + L ++ + GH A + Sbjct: 59 RNSKYDWAYKTTMVRRDDYERIEKPNTRGKTLGGSSSL----NYFTWVPGHKATFDQWE- 113 Query: 183 TIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG 240 E GK++T P P+ + S D EL +G G Sbjct: 114 --EFGGKEWTWD---------PLVPYLRK----SATYHDDPRLYSPELEK----IGGG 152 >1E3J-A nrPDB Length = 352 Score = 33.4 bits (75), Expect = 0.24, Method: Composition-based stats. Identities = 21/62 (33%), Positives = 23/62 (37%), Gaps = 11/62 (17%) Query: 32 EPAALTRALSRAM-ACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARA 90 E AL LS + ACR+ AG LVIG G GL S A GA Sbjct: 146 EEGALLEPLSVGVHACRR----------AGVQLGTTVLVIGAGPIGLVSVLAAKAYGAFV 195 Query: 91 AV 92 Sbjct: 196 VC 197 >6MO6-A nrPDB Length = 414 Score = 33.4 bits (75), Expect = 0.27, Method: Composition-based stats. Identities = 43/286 (15%), Positives = 86/286 (30%), Gaps = 48/286 (16%) Query: 165 SHIEIIRGHAAFTSDPKPTI-EVSGKKYTAPHILIATGGMPSTPHESQIP--------GA 215 S +E I+ + K I +K + +++IA G +P G+ Sbjct: 69 SGVEWIKARVTELNPDKNCIHTDDDEKISYRYLIIALGIQLDYEKIKGLPEGFAHPKIGS 128 Query: 216 SLGITS--------------DGFFQLEELPGRSVIVGA--GYIAVEMAGILSALGSKTSL 259 + + + + F P + GA + + A G ++ Sbjct: 129 NYSVKTVEKTWKALQDFKEGNAIFTFPNTPVK--CAGAPQKIMYLSEA-YFRKTGKRSKA 185 Query: 260 -MIRHDKVLRSFD-SMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRL 317 +I + + F + E ++ + V + ++ E Sbjct: 186 NIIFNTSLGAIFGVKKYADALQEIIQERNLTV--NYKKNLIEVRADKQEAVFENLDK--- 240 Query: 318 PVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEF--QNTNVKGIYAVGD 375 P T + + L P + K D G + VD+ Q+ ++ +GD Sbjct: 241 PGETQVISYEMLHV----TPPMSPPDVLKTSPVADAAGWVDVDKETLQHRRYPNVFGIGD 296 Query: 376 VCGKA---LLTPVAIAAG---RKLAHRLFEYKEDSKLD-YNNIPTV 414 VA +G R ++ + K D Y + P V Sbjct: 297 CTNLPTSKTAAAVAAQSGILDRTISVIMKNQTPTKKYDGYTSCPLV 342 >4K22-A nrPDB Length = 365 Score = 33.4 bits (75), Expect = 0.28, Method: Composition-based stats. Identities = 14/35 (40%), Positives = 18/35 (51%) Query: 62 VASYDYLVIGGGSGGLASARRAAELGARAAVVESH 96 + S D ++GGG GLA A G R AV+E Sbjct: 1 MQSVDVAIVGGGMVGLAVACGLQGSGLRVAVLEQR 35 >3OJO-A nrPDB Length = 431 Score = 33.0 bits (74), Expect = 0.31, Method: Composition-based stats. Identities = 20/109 (18%), Positives = 37/109 (33%), Gaps = 23/109 (21%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF 292 + +VG GYI + + + + G + I+ ++L+N + + Sbjct: 13 KLTVVGLGYIGLPTSIMFAKHGVDVLGV------------DINQQTIDKLQNGQISI--- 57 Query: 293 SQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKD 341 + EV G+L V T D + A+ PN D Sbjct: 58 -------EEPGLQEVYEEVLSSGKLKVSTTPEASDVFIIAV-PTPNNDD 98 >3G5Q-A nrPDB Length = 443 Score = 33.0 bits (74), Expect = 0.31, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 14/36 (38%) Query: 232 GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVL 267 R +VGAG E A L LG L K + Sbjct: 2 ERVNVVGAGLAGSEAAWTLLRLGVPVRLFEMRPKRM 37 Score = 28.0 bits (61), Expect = 9.5, Method: Composition-based stats. Identities = 8/26 (30%), Positives = 11/26 (42%) Query: 69 VIGGGSGGLASARRAAELGARAAVVE 94 V+G G G +A LG + E Sbjct: 6 VVGAGLAGSEAAWTLLRLGVPVRLFE 31 >3HM2-A nrPDB Length = 178 Score = 33.0 bits (74), Expect = 0.31, Method: Composition-based stats. Identities = 21/81 (25%), Positives = 31/81 (38%), Gaps = 15/81 (18%) Query: 36 LTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGG---SGGLASARR----AAELGA 88 L+ A++ ++ R Q P + D + IGGG G A+A + L A Sbjct: 66 LSNAINLGVSDRIAVQQGAPRAFDDVPDNPDVIFIGGGLTAPGVFAAAWKRLPVGGRLVA 125 Query: 89 RAAVVE--------SHKLGGT 101 A VE + GGT Sbjct: 126 NAVTVESEQMLWALRKQFGGT 146 >4NEG-A nrPDB Length = 400 Score = 33.0 bits (74), Expect = 0.36, Method: Composition-based stats. Identities = 20/74 (27%), Positives = 29/74 (39%), Gaps = 4/74 (5%) Query: 428 EDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEM 487 EDEA K +KTY TP+Y A + K+ ++ G H Sbjct: 43 EDEAFQKELNHYLKTYVGRETPLYFAENMTEYCGGAKIYLKREDLNHTGAHKINNT---- 98 Query: 488 LQGFAVAVKMGATK 501 + +AV+MG K Sbjct: 99 IGQALLAVRMGKKK 112 >1X14-A nrPDB Length = 401 Score = 33.0 bits (74), Expect = 0.37, Method: Composition-based stats. Identities = 10/55 (18%), Positives = 22/55 (40%) Query: 231 PGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENA 285 P + +++GAG + G ++LG+ +V SM + + + Sbjct: 172 PAKVMVIGAGVAGLAAIGAANSLGAIVRAFDTRPEVKEQVQSMGAEFLELDFKEE 226 Score = 30.3 bits (67), Expect = 2.2, Method: Composition-based stats. Identities = 16/43 (37%), Positives = 20/43 (46%) Query: 54 GPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESH 96 G AAG V +VIG G GLA+ A LGA ++ Sbjct: 162 GQITAAGKVPPAKVMVIGAGVAGLAAIGAANSLGAIVRAFDTR 204 >3BI4-A nrPDB Length = 516 Score = 32.6 bits (73), Expect = 0.38, Method: Composition-based stats. Identities = 9/36 (25%), Positives = 17/36 (47%), Gaps = 1/36 (2%) Query: 232 GRSVIVGAGYIAVEMAGILSALG-SKTSLMIRHDKV 266 + +I+GAG ++ A L G ++ D+V Sbjct: 9 KKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRV 44 Score = 31.1 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 19/36 (52%), Gaps = 2/36 (5%) Query: 67 YLVIGGGSGGLASARRAAELGAR-AAVVE-SHKLGG 100 ++IG G GL +A + G + V+E ++GG Sbjct: 11 VIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGG 46 >3RED-A nrPDB Length = 521 Score = 32.6 bits (73), Expect = 0.39, Method: Composition-based stats. Identities = 13/36 (36%), Positives = 20/36 (55%), Gaps = 1/36 (2%) Query: 63 ASYDYLVIGGGSGGLASARRAAELGARAAVVESHKL 98 SYDY+++GGG+ G A +E + V+E L Sbjct: 25 GSYDYVIVGGGTSGCPLAATLSE-KYKVLVLERGTL 59 >4MIF-A nrPDB Length = 620 Score = 32.6 bits (73), Expect = 0.41, Method: Composition-based stats. Identities = 10/37 (27%), Positives = 14/37 (37%) Query: 61 AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHK 97 A YD + G G G A+ + R +VE Sbjct: 10 ADEPYDVFIAGSGPIGATFAKLCVDANLRVCMVEIGA 46 >4HA6-A nrPDB Length = 508 Score = 32.6 bits (73), Expect = 0.42, Method: Composition-based stats. Identities = 11/33 (33%), Positives = 22/33 (66%), Gaps = 1/33 (3%) Query: 66 DYLVIGGGSGG-LASARRAAELGARAAVVESHK 97 D +++GGGS G L +AR + + +R ++E+ + Sbjct: 3 DIVIVGGGSAGSLLAARLSEDPDSRVLLIEAGE 35 >4U2L-A nrPDB Length = 510 Score = 32.6 bits (73), Expect = 0.43, Method: Composition-based stats. Identities = 12/31 (38%), Positives = 17/31 (54%) Query: 68 LVIGGGSGGLASARRAAELGARAAVVESHKL 98 +VIG G G SA R E G + ++E +L Sbjct: 9 VVIGTGYGAAVSALRLGEAGVQTLMLEMGQL 39 >6J0Z-C nrPDB Length = 491 Score = 32.6 bits (73), Expect = 0.45, Method: Composition-based stats. Identities = 9/30 (30%), Positives = 13/30 (43%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVES 95 D +V+G G GL A G V++ Sbjct: 7 DVVVVGAGPTGLMLAGELRLAGVSVVVLDK 36 Score = 28.4 bits (62), Expect = 7.9, Method: Composition-based stats. Identities = 15/86 (17%), Positives = 29/86 (33%), Gaps = 1/86 (1%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSM-ISTNCTEELENAGVEVLK 291 V+VGAG + +AG L G ++ + + ++ ++ S EE G+ Sbjct: 7 DVVVVGAGPTGLMLAGELRLAGVSVVVLDKLAEPIKESRALGFSARTIEEFAQRGLMDRF 66 Query: 292 FSQVKEVKKTLSGLEVSMVTAVPGRL 317 G+ + G Sbjct: 67 GEVGVIPVGHFGGVPLDYQVIEGGSY 92 >3HN2-A nrPDB Length = 312 Score = 32.6 bits (73), Expect = 0.45, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 15/32 (46%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHD 264 R IVGAG + + +L G ++R D Sbjct: 4 RIAIVGAGALGLYYGALLQRSGEDVHFLLRRD 35 >4IV9-A nrPDB Length = 557 Score = 32.6 bits (73), Expect = 0.45, Method: Composition-based stats. Identities = 14/56 (25%), Positives = 20/56 (35%), Gaps = 2/56 (3%) Query: 233 RSVIVGAGYIAVEMAGILSALGSK-TSLMIRHDKV-LRSFDSMISTNCTEELENAG 286 R IVGAG + A L G K L D++ R + + + G Sbjct: 40 RVAIVGAGISGLVAATELLRAGVKDVVLYESRDRIGGRVWSQVFDQTRPRYIAEMG 95 Score = 30.7 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 9/36 (25%), Positives = 16/36 (44%), Gaps = 2/36 (5%) Query: 67 YLVIGGGSGGLASARRAAELGAR-AAVVE-SHKLGG 100 ++G G GL +A G + + E ++GG Sbjct: 41 VAIVGAGISGLVAATELLRAGVKDVVLYESRDRIGG 76 >4G65-A nrPDB Length = 461 Score = 32.6 bits (73), Expect = 0.46, Method: Composition-based stats. Identities = 23/134 (17%), Positives = 44/134 (32%), Gaps = 20/134 (14%) Query: 226 QLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENA 285 +LE+ R +IVG G I +A L L+ R+ + +EELEN Sbjct: 230 RLEKPYRRIMIVGGGNIGASLAKRLEQT-YSVKLIERN--------LQRAEKLSEELENT 280 Query: 286 GV--------EVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVP 337 V E+L + +V + ++ ++ ++ I R Sbjct: 281 IVFCGDAADQELLTEENIDQVDVF---IALTNEDETNIMSAMLAKRMGAKKVMVLIQRGA 337 Query: 338 NTKDLSLNKLGIQT 351 + + + Sbjct: 338 YVDLVQGGVIDVAI 351 >2BS2-A nrPDB Length = 660 Score = 32.6 bits (73), Expect = 0.47, Method: Composition-based stats. Identities = 12/28 (42%), Positives = 15/28 (53%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVV 93 D LVIGGG GL +A + G V+ Sbjct: 7 DSLVIGGGLAGLRAAVATQQKGLSTIVL 34 >5OC1-A nrPDB Length = 565 Score = 32.6 bits (73), Expect = 0.48, Method: Composition-based stats. Identities = 10/34 (29%), Positives = 19/34 (55%), Gaps = 1/34 (2%) Query: 64 SYDYLVIGGGSGG-LASARRAAELGARAAVVESH 96 +DY+V+G G+ G + +AR + V+E+ Sbjct: 1 DFDYVVVGAGNAGNVVAARLTEDPDVSVLVLEAG 34 >1DOD-A nrPDB Length = 394 Score = 32.6 bits (73), Expect = 0.48, Method: Composition-based stats. Identities = 15/58 (25%), Positives = 25/58 (43%), Gaps = 3/58 (5%) Query: 234 SVIVGAGYIAVEMAGILSALGSKTSLMIRH--DKVL-RSFDSMISTNCTEELENAGVE 288 I+GAG + + +L G ++ R D VL R ++ + L AGV+ Sbjct: 5 VAIIGAGPSGLLLGQLLHKAGIDNVILERQTPDYVLGRIRAGVLEQGMVDLLREAGVD 62 >5TUM-A nrPDB Length = 410 Score = 32.6 bits (73), Expect = 0.49, Method: Composition-based stats. Identities = 26/156 (16%), Positives = 42/156 (26%), Gaps = 16/156 (10%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKL---GGTCVNVGCVPKKV---MWNTAVHS 120 LVIG G G A G ++E + GG ++V + + M Sbjct: 28 ILVIGAGVAGPAVCYWLRRFGFSPVLIEKYASIRKGGQALDVRGIATHIAREMGIYDQIC 87 Query: 121 EFMHDHADYGFPSCEGKFN----WRVIKEKRDAYVSRLNAIYQNNLTKSHIE---IIRGH 173 E F GK ++D V L L K+ + Sbjct: 88 EMRTRIERGRFVDSSGKVLHEEQGEKFGFRQDDEVEILRGDLVEILMKTIADVPCYFNQS 147 Query: 174 AAFTSDPKPTIEV---SGKKYTAPHILIATGGMPST 206 + V G+ ++ A G + Sbjct: 148 IISIEQNADNVTVIFMDGRIEQYDLVIAADGIHSAI 183 Score = 30.7 bits (68), Expect = 1.9, Method: Composition-based stats. Identities = 33/208 (15%), Positives = 65/208 (31%), Gaps = 15/208 (7%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDS-MISTNCTEELENAGVEVLK 291 + +++GAG + L G L+ ++ + + + + T G+ Sbjct: 27 KILVIGAGVAGPAVCYWLRRFGFSPVLIEKYASIRKGGQALDVRGIATHIAREMGIYDQI 86 Query: 292 FSQVKEVK-KTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQ 350 ++ ++ G +V+ L R + L + Sbjct: 87 CEMRTRIERGRFVDSSGKVLHEEQGEKFGFRQDDEVEIL-----RGDLVEILMKTIADVP 141 Query: 351 TDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNN 410 II E NV I+ G + + L A + +FE E + Sbjct: 142 CYFNQSIISIEQNADNVTVIFMDGRI-EQYDLVIAADGIHSAIRRMIFEKNEYQLIHLGA 200 Query: 411 IPTVVFSHPPIGTVGLT----EDEAIHK 434 + F+ P +GL+ E EA +K Sbjct: 201 YLST-FTIPNY--LGLSHIDLECEANNK 225 >3LOV-A nrPDB Length = 475 Score = 32.2 bits (72), Expect = 0.58, Method: Composition-based stats. Identities = 12/37 (32%), Positives = 20/37 (54%), Gaps = 3/37 (8%) Query: 67 YLVIGGGSGGLASARRAAEL--GARAAVVESHK-LGG 100 +++GGG GLA+A A ++E+ + LGG Sbjct: 7 LVIVGGGITGLAAAYYAERAFPDLNITLLEAGERLGG 43 >2Y0D-A nrPDB Length = 478 Score = 32.2 bits (72), Expect = 0.60, Method: Composition-based stats. Identities = 41/288 (14%), Positives = 84/288 (29%), Gaps = 46/288 (15%) Query: 234 SVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFS 293 I+G+G + + L+ +G F + + L N GV + + Sbjct: 11 LTIIGSGKVGLVTGACLADIGHDV------------FCLDVDQAKIDILNNGGVPIHEPG 58 Query: 294 QVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKD-LSLNKLGIQTD 352 + + + S + T + + D A+G P+ L + Sbjct: 59 LKEVIARNRSAGRLRFSTD------IEAAVAHGDVQFIAVGTPPDEDGSADLQYVLAAAR 112 Query: 353 DKGH------IIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKL 406 + G +IVD + V VG + + VA ++ ++F + + Sbjct: 113 NIGRYMTGFKVIVD---KSTVP----VG--TAERVRAAVAEELAKRGGDQMFSVVSNPEF 163 Query: 407 DYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSF-TPMYHAVTKR-KTKCVMK 464 F+ P +G +D+ + E +K F + ++ K Sbjct: 164 LKEGAAVDDFTRPDRIVIG-CDDDVPGERARELMKKLYAPFNRNHERTLYMDVRSAEFTK 222 Query: 465 MVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHP 512 M M + +A + GA + P Sbjct: 223 YAANA---------MLATRISFMNELANLADRFGADIEAVRRGIGSDP 261 Score = 29.1 bits (64), Expect = 4.4, Method: Composition-based stats. Identities = 12/47 (25%), Positives = 21/47 (44%) Query: 63 ASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVP 109 S + +IG G GL + A++G ++ + +N G VP Sbjct: 7 GSMNLTIIGSGKVGLVTGACLADIGHDVFCLDVDQAKIDILNNGGVP 53 >4Z25-A nrPDB Length = 652 Score = 32.2 bits (72), Expect = 0.61, Method: Composition-based stats. Identities = 8/32 (25%), Positives = 15/32 (46%), Gaps = 1/32 (3%) Query: 66 DYLVIGGGSGGLASARRAAE-LGARAAVVESH 96 D ++IG G+ G A A + ++E+ Sbjct: 8 DIVIIGAGAAGSLLAHYLARFSNMKIILLEAG 39 >3VRD-B nrPDB Length = 401 Score = 31.8 bits (71), Expect = 0.65, Method: Composition-based stats. Identities = 56/326 (17%), Positives = 99/326 (30%), Gaps = 52/326 (15%) Query: 148 DAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEV-SGKKYTAPHILIATGGMPST 206 D ++ L Y L I+++ A K ++ G ++ ++A G Sbjct: 52 DRELASLRVGYDG-LRAHGIQVVHDSALGIDPDKKLVKTAGGAEFAYDRCVVAPGIDLLY 110 Query: 207 PHESQ--------IPGASLGITSDGFFQ--LEELPGRSVIVGAGYI------------AV 244 +P A + LE + V++ A A Sbjct: 111 DKIEGYSEALAAKLPHAWKAGEQTALLRRQLESMDDGGVVIIAPPAPPFRCPPGPYERAS 170 Query: 245 EMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEEL----ENAGVEVLKFSQVKEVKK 300 ++A L A SK+ ++I + S + + ENA +E VK Sbjct: 171 QIAHYLKAHKSKSKVIILDNSQTFSKQAQFTKGWERLYGFGTENALIEWHPGPDAAVVKT 230 Query: 301 TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD 360 + V + V+ +IP P + T+D G VD Sbjct: 231 DTEAMTVETSFGETFKAAVINLIP------------PQRAGKIAQSASL-TNDSGWCPVD 277 Query: 361 -EFQNTNV-KGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSH 418 +++ GI+ +GD C A + A +A + K + P+ + + Sbjct: 278 IRTFESSLQPGIHVIGDACNAAPMPKSAYSANSQAKVAAAAVVALLKGEEPGTPSYLNTC 337 Query: 419 PPIGTVGLTEDEAIHKYGIENVKTYS 444 I G YGI Y Sbjct: 338 YSILAPG---------YGISIAAVYR 354 >3CP2-A nrPDB Length = 649 Score = 31.8 bits (71), Expect = 0.65, Method: Composition-based stats. Identities = 10/29 (34%), Positives = 18/29 (62%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVV 93 +D ++IGGG G +A AA +G + ++ Sbjct: 27 FDVIIIGGGHAGTEAAMAAARMGQQTLLL 55 >3G05-A nrPDB Length = 576 Score = 31.8 bits (71), Expect = 0.69, Method: Composition-based stats. Identities = 10/29 (34%), Positives = 18/29 (62%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVV 93 +D ++IGGG G +A AA +G + ++ Sbjct: 33 FDVIIIGGGHAGTEAAMAAARMGQQTLLL 61 >3RP7-A nrPDB Length = 407 Score = 31.8 bits (71), Expect = 0.70, Method: Composition-based stats. Identities = 12/30 (40%), Positives = 17/30 (56%) Query: 68 LVIGGGSGGLASARRAAELGARAAVVESHK 97 +VIG G GGL++A + G V E+ K Sbjct: 27 IVIGAGIGGLSAAVALKQSGIDCDVYEAVK 56 >2CDC-A nrPDB Length = 366 Score = 31.8 bits (71), Expect = 0.71, Method: Composition-based stats. Identities = 15/109 (13%), Positives = 32/109 (29%), Gaps = 31/109 (28%) Query: 232 GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLK 291 + ++VG G I V + G + + R + Sbjct: 182 RKVLVVGTGPIGVLFTLLFRTYGLEVWMANRRE--------------------------- 214 Query: 292 FSQVKEVKKTL-SGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNT 339 EV++T+ + + + G + + D ++ A G N Sbjct: 215 ---PTEVEQTVIEETKTNYYNSSNGYDKLKDSVGKFDVIIDATGADVNI 260 >5XGV-A nrPDB Length = 462 Score = 31.8 bits (71), Expect = 0.76, Method: Composition-based stats. Identities = 12/32 (37%), Positives = 15/32 (46%), Gaps = 1/32 (3%) Query: 66 DYLVI-GGGSGGLASARRAAELGARAAVVESH 96 D ++I GGG GL A G V+E H Sbjct: 2 DTVIIAGGGPVGLMLACELGLAGVDTVVLERH 33 Score = 29.9 bits (66), Expect = 3.0, Method: Composition-based stats. Identities = 14/55 (25%), Positives = 22/55 (40%), Gaps = 1/55 (1%) Query: 234 SVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVL-RSFDSMISTNCTEELENAGV 287 +I G G + + +A L G T ++ RHD S I+ E G+ Sbjct: 4 VIIAGGGPVGLMLACELGLAGVDTVVLERHDAPREPSRGGAINATVVELFTQRGI 58 >5UY8-A nrPDB Length = 601 Score = 31.8 bits (71), Expect = 0.77, Method: Composition-based stats. Identities = 21/102 (20%), Positives = 40/102 (39%), Gaps = 14/102 (13%) Query: 378 GKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP----IGTVGLTEDEAIH 433 G+ A+ AG + + + ++LD+N I V + P + + G+T +EA+ Sbjct: 72 GRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVE 131 Query: 434 KYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVV 475 + I V K + +VC ++ VV Sbjct: 132 QIDIGGVTLLR----------AAAKNHARVTVVCEPEDYVVV 163 >4Z44-A nrPDB Length = 554 Score = 31.8 bits (71), Expect = 0.81, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 20/36 (55%), Gaps = 3/36 (8%) Query: 66 DYLVIGGGSGGLASA---RRAAELGARAAVVESHKL 98 + +++GGG+ G +A RA + A ++ES + Sbjct: 23 NIVIVGGGTAGWMAASYLVRALQQQANITLIESAAI 58 >3IHM-A nrPDB Length = 430 Score = 31.8 bits (71), Expect = 0.83, Method: Composition-based stats. Identities = 7/30 (23%), Positives = 12/30 (40%) Query: 230 LPGRSVIVGAGYIAVEMAGILSALGSKTSL 259 + R IVGAG + + L ++ Sbjct: 21 MKKRIGIVGAGTAGLHLGLFLRQHDVDVTV 50 >3GG2-A nrPDB Length = 450 Score = 31.4 bits (70), Expect = 0.89, Method: Composition-based stats. Identities = 16/44 (36%), Positives = 23/44 (52%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVP 109 D V+G G GL SA AELGA +++ + +N G +P Sbjct: 4 DIAVVGIGYVGLVSATCFAELGANVRCIDTDRNKIEQLNSGTIP 47 Score = 31.1 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 17/102 (16%), Positives = 38/102 (37%), Gaps = 18/102 (17%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF 292 +VG GY+ + A + LG+ R D+ + E+L + + + + Sbjct: 4 DIAVVGIGYVGLVSATCFAELGANV----------RCIDTDRNKI--EQLNSGTIPIYEP 51 Query: 293 SQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIG 334 K + + + + T + +P+ D + A+G Sbjct: 52 GLEKMIARNVKAGRLRFGT------EIEQAVPEADIIFIAVG 87 >3T7C-A nrPDB Length = 299 Score = 31.4 bits (70), Expect = 0.98, Method: Composition-based stats. Identities = 25/112 (22%), Positives = 38/112 (33%), Gaps = 13/112 (11%) Query: 49 EPQPQGPPPAAGAVASYDYLVIGGGSG-GLASARRAAELGARAAVVE-SHKLGGTCVNVG 106 E Q QGP AG V + G G G + A A GA ++ +L G Sbjct: 13 EAQTQGPGSMAGKVEGKVAFITGAARGQGRSHAITLAREGADIIAIDVCKQLDGV----- 67 Query: 107 CVPKKVMWNTAVHSEFMHDHADYG---FPSCEGKFNWRVIKEKRDAYVSRLN 155 K M +E + G S ++ ++ D V++L Sbjct: 68 ---KLPMSTPDDLAETVRQVEALGRRIIASQVDVRDFDAMQAAVDDGVTQLG 116 >3SM8-A nrPDB Length = 381 Score = 31.1 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 16/36 (44%), Gaps = 1/36 (2%) Query: 62 VASYDYLVIGGGSGGLASARRAAELGARAAVVESHK 97 DYLVIG G G ++ + G R V+E Sbjct: 7 PIEADYLVIGAGIAGASTGYWLSAHG-RVVVLEREA 41 >3LLV-A nrPDB Length = 141 Score = 31.1 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 10/33 (30%), Positives = 16/33 (48%) Query: 65 YDYLVIGGGSGGLASARRAAELGARAAVVESHK 97 Y+Y+VIG + G+ R G + V+ K Sbjct: 7 YEYIVIGSEAAGVGLVRELTAAGKKVLAVDKSK 39 >4B2T-D nrPDB Length = 542 Score = 31.1 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 34/204 (16%), Positives = 69/204 (33%), Gaps = 16/204 (7%) Query: 131 FPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKK 190 + +F + I K A+V + A + + + G I+++G Sbjct: 331 IEREDIEFICKTIGTKPVAHVDQFTADMLGSAELAEEVSLNGSGKL-------IKITGCA 383 Query: 191 YTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGIL 250 + I G E + + R++I G G +E+A L Sbjct: 384 SPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCL----VKKRALIAGGGAPEIELALRL 439 Query: 251 SALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEV-KKTLSGLEVSM 309 + +L +R+F + + ENAG+ + S V E+ + G + + Sbjct: 440 TEYSR--TLSGMESYCIRAFADAMEVIPSTLAENAGLNPI--STVTELRNRHAQGEKTTG 495 Query: 310 VTAVPGRLPVMTMIPDVDCLLWAI 333 + G + + V LL ++ Sbjct: 496 INVRKGGISNILEELVVQPLLVSV 519 >4FHN-X nrPDB Length = 450 Score = 31.1 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 27/154 (17%), Positives = 44/154 (28%), Gaps = 15/154 (9%) Query: 110 KKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEI 169 +K M A S K + E + S + + + + Sbjct: 252 EKAMEFGARVITASDSSGTVVDESGFTKEKLARLIEIK----SSRDGRVADYAKEFGLVY 307 Query: 170 IRG---HAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQ 226 + G + P + A H LIA G + I + FQ Sbjct: 308 LEGQQPWSVPVDIALPCATQNELDVDAAHQLIANGVKAVAEGAN----MPTTIEATELFQ 363 Query: 227 LEEL---PGRSVIVGA-GYIAVEMAGILSALGSK 256 + PG++ G +EMA + LG K Sbjct: 364 QAGVLFAPGKAANAGGVATSGLEMAQNAARLGWK 397 >6DLL-A nrPDB Length = 398 Score = 31.1 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 20/116 (17%), Positives = 43/116 (37%), Gaps = 6/116 (5%) Query: 228 EELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGV 287 + + I+GAG + + +L G ++ R + + ++ LE V Sbjct: 2 NAMKTQVAIIGAGPSGLLLGQLLHKAGIDNIIVERQ-----TAEYVLGRIRAGVLEQGTV 56 Query: 288 EVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAI-GRVPNTKDL 342 ++L+ + V E + + V GR + + + G+ T+DL Sbjct: 57 DLLREAGVAERMDREGLVHEGVELLVGGRRQRLDLKALTGGKTVMVYGQTEVTRDL 112 >1LTX-R nrPDB Length = 650 Score = 30.7 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 13/45 (28%), Positives = 20/45 (44%), Gaps = 3/45 (6%) Query: 58 AAGAVASYDYLVIGGG-SGGLASARRAAELGARAAVVESHK-LGG 100 A + +D +VIG G + +A + G R V+S GG Sbjct: 2 ADNLPSDFDVIVIGTGLPESIIAAA-CSRSGQRVLHVDSRSYYGG 45 >3KKJ-A nrPDB Length = 336 Score = 30.7 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 8/34 (23%), Positives = 16/34 (47%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKLGG 100 +IG G GL++A+ G + + + + G Sbjct: 5 IAIIGTGIAGLSAAQALTAAGHQVHLFDKSRGSG 38 >5NCC-A nrPDB Length = 594 Score = 30.7 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 15/41 (36%), Positives = 22/41 (53%), Gaps = 3/41 (7%) Query: 57 PAAGAVASYDYLVIGGGSGGLASARRAAELG-ARAAVVESH 96 P AG YDY+++GGG+ A R + G R V+E+ Sbjct: 18 PVAGQ--KYDYILVGGGTAACVLANRLSADGSKRVLVLEAG 56 >4ZCC-A nrPDB Length = 336 Score = 30.7 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 8/34 (23%), Positives = 16/34 (47%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKLGG 100 +IG G GL++A+ G + + + + G Sbjct: 5 IAIIGTGIAGLSAAQALTSAGHQVHLFDKSRGSG 38 >4R16-A nrPDB Length = 418 Score = 30.7 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 31/71 (43%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF 292 R ++G GYI + A + ++ G +V++ +S ++ E++ EVL Sbjct: 2 RIAVLGLGYIGLPTAIMFASSGYDVVGYDIRSEVIKKINSGVAHIIEPEIDRRLKEVLSL 61 Query: 293 SQVKEVKKTLS 303 ++K + Sbjct: 62 GKLKVTDRVED 72 >4B4O-A nrPDB Length = 298 Score = 30.7 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 10/37 (27%), Positives = 19/37 (51%), Gaps = 1/37 (2%) Query: 233 RSVIVGA-GYIAVEMAGILSALGSKTSLMIRHDKVLR 268 R ++ G G+I + +L+A G + +L+ R R Sbjct: 2 RVLVGGGTGFIGTALTQLLNARGHEVTLVSRKPGPGR 38 >2GV8-A nrPDB Length = 447 Score = 30.7 bits (68), Expect = 1.9, Method: Composition-based stats. Identities = 10/38 (26%), Positives = 16/38 (42%), Gaps = 3/38 (7%) Query: 67 YLVIGGGSGGLASARR--AAELGARAAVVE-SHKLGGT 101 +IG G GL +A+ A + + + E GG Sbjct: 9 IAIIGAGPSGLVTAKALLAEKAFDQVTLFERRGSPGGV 46 >2YFH-A nrPDB Length = 448 Score = 30.7 bits (68), Expect = 1.9, Method: Composition-based stats. Identities = 29/204 (14%), Positives = 57/204 (27%), Gaps = 18/204 (8%) Query: 110 KKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEI 169 +K M A S K + E + + + + + + Sbjct: 248 EKAMEFGARVITASDSSGTVVDESGFTKEKLARLIEIK----ASRDGRVADYAKEFGLVY 303 Query: 170 IRG---HAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQ 226 + G + P + A H LIA G + I + FQ Sbjct: 304 LEGQQPWSLPVDIALPCATQNELDVDAAHQLIANGVKAVAEGAN----MPTTIEATELFQ 359 Query: 227 LEEL---PGRSVIVGA-GYIAVEMAGILSALGSKT-SLMIRHDKVLRSFDSMISTNCTEE 281 + PG++ G +EMA + LG K + R ++ + Sbjct: 360 QAGVLFAPGKAANAGGVATSGLEMAQNAARLGWKAEKVDARLHHIMTDIHDGSAAAAERY 419 Query: 282 LENAGVEVLKFSQVKEVKKTLSGL 305 G ++ + + +K + Sbjct: 420 --GLGYNLVAGANIVGFQKIADAM 441 >3GMC-A nrPDB Length = 415 Score = 30.3 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 16/68 (23%), Positives = 27/68 (39%), Gaps = 10/68 (14%) Query: 228 EELPGRS---VIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELEN 284 + PG++ + G G+ + A L G L LR+F + I L + Sbjct: 41 NKTPGKTRRAEVAGGGFAGLTAAIALKQNGWDVRL-HEKSSELRAFGAGI------YLWH 93 Query: 285 AGVEVLKF 292 G+ VL+ Sbjct: 94 NGLRVLEG 101 >2CUL-A nrPDB Length = 232 Score = 30.3 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 18/32 (56%) Query: 62 VASYDYLVIGGGSGGLASARRAAELGARAAVV 93 +A+Y L++G G G +A A+ G R ++ Sbjct: 1 MAAYQVLIVGAGFSGAETAFWLAQKGVRVGLL 32 Score = 28.7 bits (63), Expect = 6.4, Method: Composition-based stats. Identities = 10/27 (37%), Positives = 15/27 (55%) Query: 234 SVIVGAGYIAVEMAGILSALGSKTSLM 260 +IVGAG+ E A L+ G + L+ Sbjct: 6 VLIVGAGFSGAETAFWLAQKGVRVGLL 32 >2EEZ-A nrPDB Length = 369 Score = 30.3 bits (67), Expect = 2.1, Method: Composition-based stats. Identities = 11/48 (22%), Positives = 22/48 (45%) Query: 231 PGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNC 278 P VI+G G + A I +G++ +++ + K L+ D + Sbjct: 166 PASVVILGGGTVGTNAAKIALGMGAQVTILDVNHKRLQYLDDVFGGRV 213 Score = 29.1 bits (64), Expect = 4.9, Method: Composition-based stats. Identities = 10/34 (29%), Positives = 21/34 (61%) Query: 61 AVASYDYLVIGGGSGGLASARRAAELGARAAVVE 94 VA +++GGG+ G +A+ A +GA+ +++ Sbjct: 163 GVAPASVVILGGGTVGTNAAKIALGMGAQVTILD 196 >2B76-A nrPDB Length = 602 Score = 30.3 bits (67), Expect = 2.2, Method: Composition-based stats. Identities = 9/22 (40%), Positives = 14/22 (63%) Query: 355 GHIIVDEFQNTNVKGIYAVGDV 376 G I D+ T +KG++AVG+ Sbjct: 360 GGIETDQNCETRIKGLFAVGEC 381 >5WIT-1k nrPDB Length = 129 Score = 29.9 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 16/59 (27%), Positives = 26/59 (44%), Gaps = 7/59 (11%) Query: 61 AVASYDYLVIGGGSGGLASARRAAE-LGARA-AVVESHKLGGTCVNVGCVPKKVMWNTA 117 + S D +V G G G A RA + G + ++V+ + + GC PKK + Sbjct: 76 GMQSVDVIVRGTG-AGREQAIRALQASGLQVKSIVDDTPV----PHNGCRPKKKFRKAS 129 >1XFD-A nrPDB Length = 723 Score = 29.9 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 14/56 (25%), Positives = 27/56 (48%), Gaps = 5/56 (8%) Query: 463 MKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEEL 518 K+ + E+ +G+H EM + VA ++ A + + IHPT+ E++ Sbjct: 619 FKLYASAFSERYLGLHGLDNRAYEMTK---VAHRVSALEEQ--QFLIIHPTADEKI 669 >4XRR-A nrPDB Length = 456 Score = 29.9 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 10/31 (32%), Positives = 17/31 (54%) Query: 231 PGRSVIVGAGYIAVEMAGILSALGSKTSLMI 261 P + VI GAGY+ +A L+ G++ + Sbjct: 15 PLKVVIAGAGYVGTCLAVTLAGRGAEVVAVD 45 >2BTW-A nrPDB Length = 254 Score = 29.9 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 17/91 (18%), Positives = 31/91 (34%), Gaps = 13/91 (14%) Query: 220 TSDGFFQLEELPGRSVIVGAGYIAV------EMAGILSALGSKTSLMIRHDKVLRSFDSM 273 T D FF E ++ +A E+ ++++ G K + D + Sbjct: 110 TQDNFFSNE---KTKAVIAPEVVARQGMTLDELGRLIASYGVKVKVNHASDTNI----ED 162 Query: 274 ISTNCTEELENAGVEVLKFSQVKEVKKTLSG 304 E L+ G V+ KE+ + G Sbjct: 163 FRKQVAENLKQDGNFVIVNYLRKEIGQERGG 193 >1VRQ-A nrPDB Length = 964 Score = 29.9 bits (66), Expect = 2.9, Method: Composition-based stats. Identities = 51/290 (17%), Positives = 86/290 (29%), Gaps = 54/290 (18%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVV-ESHKLGGTCVNVGCVPKKVMWNTAVHSEFMH 124 D LV+G G GLA+AR A+ GAR ++ E + GGT + Sbjct: 129 DVLVVGAGPAGLAAAREASRSGARVMLLDERPEAGGT---------------------LR 167 Query: 125 DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEII---RGHAAFTSDPK 181 + + + + E+ A + I + P Sbjct: 168 EASGEQIDGIDAAQWIDAVTEELAAAEETTHLQRTTVFGSYDANYILAAQRRTVHLDGPS 227 Query: 182 PTIEVSGK--KYTAPHILIATGG--MPSTPHESQIPGASLGITSDGFFQLEELPGRSVIV 237 + A +++AT P + PG L + + R + Sbjct: 228 GQGVSRERIWHIRAKQVVLATAAHERPIVFENNDRPGIMLAGSVRSYL------NRFGVR 281 Query: 238 GAGYIAVE--------MAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEV 289 IAV + L+A G +++ + + ++ GV V Sbjct: 282 AGSKIAVATTNDSVYPLVSELAASGGVVAVIDARQNISAAAAQAVTD---------GVTV 332 Query: 290 LKFSQVKEVKKTLSGL--EVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVP 337 L S V + SG V + T R + D L + G P Sbjct: 333 LTGSVVANTEADASGELSAVLVATLDEQRNLGEAQRFEADVLAVSGGFNP 382 >3R3S-A nrPDB Length = 294 Score = 29.9 bits (66), Expect = 3.1, Method: Composition-based stats. Identities = 20/103 (19%), Positives = 33/103 (32%), Gaps = 6/103 (5%) Query: 58 AAGAVASYDYLVIGGGSG-GLASARRAAELGARAAV-----VESHKLGGTCVNVGCVPKK 111 +G + LV GG SG G A+A A GA A+ E + C K Sbjct: 43 GSGRLKDRKALVTGGDSGIGRAAAIAYAREGADVAINYLPAEEEDAQQVKALIEECGRKA 102 Query: 112 VMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRL 154 V+ + E + G + + + + + Sbjct: 103 VLLPGDLSDESFARSLVHKAREALGGLDILALVAGKQTAIPEI 145 >5X68-A nrPDB Length = 391 Score = 29.9 bits (66), Expect = 3.2, Method: Composition-based stats. Identities = 4/33 (12%), Positives = 12/33 (36%) Query: 232 GRSVIVGAGYIAVEMAGILSALGSKTSLMIRHD 264 + ++G G + A L+ + + + Sbjct: 15 KKVAVIGGGLVGSLQACFLAKRNFQIDVYEARE 47 >2QA2-A nrPDB Length = 499 Score = 29.5 bits (65), Expect = 3.3, Method: Composition-based stats. Identities = 9/29 (31%), Positives = 12/29 (41%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVES 95 +V+G G GL A G V+E Sbjct: 15 VIVVGAGPAGLMLAGELRLGGVDVMVLEQ 43 Score = 29.1 bits (64), Expect = 4.4, Method: Composition-based stats. Identities = 25/133 (18%), Positives = 49/133 (36%), Gaps = 10/133 (7%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSM---ISTNCTEELENAGVEV 289 ++VGAG + +AG L G ++ + + R+ +S + E + G+ Sbjct: 14 SVIVVGAGPAGLMLAGELRLGGVDVMVLEQLPQ--RTGESRGLGFTARTMEVFDQRGILP 71 Query: 290 LKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPD-VDCLL--WAIGRVPNTKDLSLNK 346 + G V V + + +L WA+GR + L + Sbjct: 72 AFGPVETSTQGHFGGRPVDFGVLEGAHYGVKAVPQSTTESVLEEWALGRGA--ELLRGHT 129 Query: 347 LGIQTDDKGHIIV 359 + TD+ H++V Sbjct: 130 VRALTDEGDHVVV 142 >5KYM-A nrPDB Length = 247 Score = 29.5 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 25/129 (19%), Positives = 48/129 (37%), Gaps = 16/129 (12%) Query: 169 IIRGHAAFTSDPKPTIEVSGKKYTAPHILI---ATGGMPSTPHESQIPGASLGITS-DGF 224 ++ G D + + + +++ ATG + +IPG + I +G Sbjct: 65 VVEGSENIPKDRNFIVVANHQSLMDIPLILGFVATGAFIAKEELRKIPGVNWYIRYLNGV 124 Query: 225 FQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEEL-- 282 F + P R+V A+ A L + + ++ + RS D + + + L Sbjct: 125 FLDRKNPRRAV------RALREAI--EKLKNGVTFIVFPEGT-RSPDGKVLSFKKDSLMI 175 Query: 283 -ENAGVEVL 290 GV VL Sbjct: 176 AVKTGVPVL 184 >5ZYN-B nrPDB Length = 471 Score = 29.5 bits (65), Expect = 3.5, Method: Composition-based stats. Identities = 9/36 (25%), Positives = 18/36 (50%), Gaps = 2/36 (5%) Query: 67 YLVIGGGSGGLASARRA-AELGARAAVVESHK-LGG 100 +VIG G GL ++ R ++ +++ +GG Sbjct: 7 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 42 Score = 28.7 bits (63), Expect = 6.1, Method: Composition-based stats. Identities = 25/131 (19%), Positives = 53/131 (40%), Gaps = 12/131 (9%) Query: 259 LMIRHDKVLRSFDSMISTNCTEELENAGVEV--------LKFSQVKEVKKTLSGLEVSMV 310 L++ DKV ++ + I+ ++ L V + L+ + + V + S +V+ Sbjct: 315 LLVMSDKVYENYTNNINFYMSKNLIK-KVSINDLIRQYDLQTTASELVTELKSYSDVNTK 373 Query: 311 TAVPGRLPVMTMIPDVDC-LLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKG 369 L + D+ +G V T + G++ ++K +I ++ G Sbjct: 374 DTFDRPLIINAFDKDISTESTVYVGEV--TPVVHFTMGGVKINEKSQVIKKNSESVLSNG 431 Query: 370 IYAVGDVCGKA 380 I+A G+V G Sbjct: 432 IFAAGEVSGGV 442 >4X4J-A nrPDB Length = 507 Score = 29.5 bits (65), Expect = 3.6, Method: Composition-based stats. Identities = 9/36 (25%), Positives = 13/36 (36%) Query: 60 GAVASYDYLVIGGGSGGLASARRAAELGARAAVVES 95 G+ ++ G G GL A G V+E Sbjct: 18 GSHMDAPVVIAGAGPAGLMLAGELRLAGIGVVVLER 53 >1LQU-A nrPDB Length = 456 Score = 29.5 bits (65), Expect = 3.6, Method: Composition-based stats. Identities = 23/109 (21%), Positives = 46/109 (42%), Gaps = 26/109 (23%) Query: 193 APHILIATGGMP----STPHESQIPGASLGITSDGFFQ--------LEELPG-RSVIVGA 239 ++ A G + P E +PG+ + G++ +L G R+V++G Sbjct: 97 YDAVIYAVGAQSDRMLNIPGE-DLPGSIAAVDFVGWYNAHPHFEQVSPDLSGARAVVIGN 155 Query: 240 GYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVE 288 G +A+++A IL + ++ R D I+ + E L G++ Sbjct: 156 GNVALDVARILL---TDPDVLARTD---------IADHALESLRPRGIQ 192 >3CUK-A nrPDB Length = 347 Score = 29.5 bits (65), Expect = 3.9, Method: Composition-based stats. Identities = 20/112 (17%), Positives = 33/112 (29%), Gaps = 24/112 (21%) Query: 233 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF 292 R V++GAG I + A + R+ VL+ D + Sbjct: 2 RVVVIGAGVIGLSTALCIH---------ERYHSVLQPLD---IKVYADRF---------- 39 Query: 293 SQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSL 344 +GL ++ D LL + PN ++L L Sbjct: 40 -TPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHV-HSPNAENLGL 89 >5XMJ-A nrPDB Length = 627 Score = 29.1 bits (64), Expect = 4.4, Method: Composition-based stats. Identities = 9/28 (32%), Positives = 13/28 (46%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVV 93 D L IGG G A A+ G + ++ Sbjct: 7 DVLCIGGALAGERVAVEASMAGLKTIML 34 >5TUF-A nrPDB Length = 409 Score = 29.1 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 12/42 (28%), Positives = 17/42 (40%), Gaps = 3/42 (7%) Query: 67 YLVIGGGSGGLASARRAAELGARAAVVESHKL---GGTCVNV 105 LVIG G G A A G ++E GG +++ Sbjct: 28 ILVIGVGVAGPAVAYWLKRFGFSPVLIEKSAAVRKGGQALDI 69 >3ADO-A nrPDB Length = 319 Score = 29.1 bits (64), Expect = 4.8, Method: Composition-based stats. Identities = 16/51 (31%), Positives = 24/51 (47%), Gaps = 7/51 (13%) Query: 57 PAAGAVASYDYLVIGGGSGGLASARRAAELGARAAV--VESHKLGGTCVNV 105 PAAG D L++G G G + A A G R + +E ++ G N+ Sbjct: 4 PAAG-----DVLIVGSGLVGRSWAMLFASGGFRVKLYDIEPRQITGALENI 49 >4IIN-A nrPDB Length = 271 Score = 29.1 bits (64), Expect = 5.0, Method: Composition-based stats. Identities = 14/56 (25%), Positives = 24/56 (42%), Gaps = 8/56 (14%) Query: 232 GRSVIVGAGY-IAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAG 286 +I GA I E+A L+++G K + R + + ++ ELE G Sbjct: 30 KNVLITGASKGIGAEIAKTLASMGLKVWINYRSN-------AEVADALKNELEEKG 78 >2DI4-A nrPDB Length = 238 Score = 29.1 bits (64), Expect = 5.0, Method: Composition-based stats. Identities = 18/64 (28%), Positives = 25/64 (39%), Gaps = 2/64 (3%) Query: 253 LGSKTSLMIRHDKVLRSFDSMISTNCTEELENAG--VEVLKFSQVKEVKKTLSGLEVSMV 310 LG T+ + +LR D + TE+ E A VE K VKK L ++ Sbjct: 134 LGGMTTAVDTSPDLLREIDEEVKRIITEQYEKAKAIVEEYKEPLKAVVKKLLEKETITCE 193 Query: 311 TAVP 314 V Sbjct: 194 EFVE 197 >5VT6-A nrPDB Length = 269 Score = 29.1 bits (64), Expect = 5.1, Method: Composition-based stats. Identities = 16/46 (34%), Positives = 22/46 (47%), Gaps = 6/46 (13%) Query: 49 EPQPQGPPPAAGAVASYDYLVIGGGSGGLASAR--RAAELGARAAV 92 E Q QGP G++ + + GG GGL +A R + G AV Sbjct: 13 EAQTQGP----GSMQAKRVAFVTGGMGGLGAAISRRLHDAGMAVAV 54 >3X2F-A nrPDB Length = 411 Score = 29.1 bits (64), Expect = 5.3, Method: Composition-based stats. Identities = 14/33 (42%), Positives = 17/33 (51%) Query: 66 DYLVIGGGSGGLASARRAAELGARAAVVESHKL 98 + +V G G G A RAA LGAR V E + Sbjct: 199 NVVVAGYGWCGRGIALRAAGLGARVIVTEVDPV 231 >2RGJ-A nrPDB Length = 402 Score = 29.1 bits (64), Expect = 5.3, Method: Composition-based stats. Identities = 11/31 (35%), Positives = 17/31 (54%), Gaps = 1/31 (3%) Query: 66 DYLVIGGGSGGLASARRAAELGA-RAAVVES 95 D L+ G G GGL+ A + G + ++ES Sbjct: 6 DILIAGAGIGGLSCALALHQAGIGKVTLLES 36 >4Z8X-A nrPDB Length = 497 Score = 29.1 bits (64), Expect = 5.4, Method: Composition-based stats. Identities = 18/64 (28%), Positives = 25/64 (39%), Gaps = 2/64 (3%) Query: 253 LGSKTSLMIRHDKVLRSFDSMISTNCTEELENAG--VEVLKFSQVKEVKKTLSGLEVSMV 310 LG T+ + +LR D + TE+ E A VE K VKK L ++ Sbjct: 393 LGGMTTAVDTSPDLLREIDEEVRRIITEQYEKAKAIVEEYKEPLKAVVKKLLEKETITCE 452 Query: 311 TAVP 314 V Sbjct: 453 EFVE 456 >1VE9-A nrPDB Length = 347 Score = 28.7 bits (63), Expect = 6.3, Method: Composition-based stats. Identities = 11/54 (20%), Positives = 19/54 (35%), Gaps = 12/54 (22%) Query: 233 RSVIVGAGYIAVEMA--------GILSALGSKTSLMIRHDKVLRSFDSMISTNC 278 R V++GAG I + A +L L K D+ + ++ Sbjct: 2 RVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVY----ADRFTPFTTTDVAAGL 51 >3U0O-A nrPDB Length = 347 Score = 28.7 bits (63), Expect = 7.1, Method: Composition-based stats. Identities = 13/47 (27%), Positives = 21/47 (44%), Gaps = 8/47 (17%) Query: 366 NVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIP 412 N++G+ A+ DV G LL L+ +++DY IP Sbjct: 218 NIEGVKAMTDVTGFGLLGH--------LSEMCQGAGVQARVDYEAIP 256 >1V8B-A nrPDB Length = 479 Score = 28.4 bits (62), Expect = 7.9, Method: Composition-based stats. Identities = 22/132 (16%), Positives = 49/132 (37%), Gaps = 5/132 (3%) Query: 230 LPGRSVIV-GAGYIAVEMAGILSALGSKTSLMIRHDKV-LRSFDSMISTNCTEELENAGV 287 + G+ V++ G G + A + LG++ + +++ + +E+ + G Sbjct: 255 ISGKIVVICGYGDVGKGCASSMKGLGARVYITEIDPICAIQAVMEGFNVVTLDEIVDKGD 314 Query: 288 EVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKL 347 + + +V K L++ AV G + V+ L G +++ Sbjct: 315 FFITCTGNVDVIKLEHLLKMKN-NAVVGNIGHFDDEIQVNELFNYKGIH--IENVKPQVD 371 Query: 348 GIQTDDKGHIIV 359 I + IIV Sbjct: 372 RITLPNGNKIIV 383 >4WES-A nrPDB Length = 534 Score = 28.4 bits (62), Expect = 8.9, Method: Composition-based stats. Identities = 8/53 (15%), Positives = 19/53 (35%) Query: 286 GVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPN 338 G + + + ++ + + V G + ++D +L IG N Sbjct: 185 GHHIANNTVMTDIIGKGNKEQKKYSINVLGEYNIGGDAWEMDRVLEKIGYHVN 237 >3F52-A nrPDB Length = 117 Score = 28.4 bits (62), Expect = 9.2, Method: Composition-based stats. Identities = 8/36 (22%), Positives = 15/36 (41%), Gaps = 1/36 (2%) Query: 478 HMQGLGCDEMLQGFAVAVKMGATKADFDNTVA-IHP 512 H G ++L A ++ + A + D + HP Sbjct: 78 HALGASVADVLIEAAGSMALQAAQEDLARVLEWSHP 113 >3K6J-A nrPDB Length = 460 Score = 28.0 bits (61), Expect = 9.8, Method: Composition-based stats. Identities = 11/54 (20%), Positives = 23/54 (42%), Gaps = 4/54 (7%) Query: 212 IPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDK 265 +P T+ + + I+G G + MA G +T L++R+++ Sbjct: 39 LPNDRGDHTNSEAYDVN----SVAIIGGGTMGKAMAICFGLAGIETFLVVRNEQ 88 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.314 0.147 0.420 Lambda K H 0.267 0.0452 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 21,581,102 Number of Sequences: 36641 Number of extensions: 981492 Number of successful extensions: 5583 Number of sequences better than 10.0: 364 Number of HSP's better than 10.0 without gapping: 389 Number of HSP's successfully gapped in prelim test: 141 Number of HSP's that attempted gapping in prelim test: 3823 Number of HSP's gapped (non-prelim): 876 length of query: 522 length of database: 10,336,785 effective HSP length: 101 effective length of query: 421 effective length of database: 6,636,044 effective search space: 2793774524 effective search space used: 2793774524 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 62 (28.3 bits)