BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P00352 (501 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5AC2-A nrPDB 1038 0.0 5AC0-A nrPDB 975 0.0 1O9J-A nrPDB 894 0.0 4X2Q-A nrPDB 777 0.0 5FHZ-A nrPDB 750 0.0 5L13-A nrPDB 720 0.0 1AG8-A nrPDB 711 0.0 4PXL-B nrPDB 542 e-154 4PZ2-A nrPDB 514 e-146 5GT6-A nrPDB 512 e-145 3RHO-A nrPDB 469 e-132 4O6R-A nrPDB 411 e-115 4QYJ-A nrPDB 410 e-114 4O5H-A nrPDB 403 e-112 6B4R-B nrPDB 394 e-110 4GO4-A nrPDB 394 e-110 5IUV-A nrPDB 384 e-107 4V3F-A nrPDB 380 e-106 1BPW-A nrPDB 378 e-105 3IWJ-A nrPDB 376 e-104 4CAZ-A nrPDB 370 e-103 2D4E-A nrPDB 369 e-102 3IWK-A nrPDB 358 3e-99 4MPY-A nrPDB 354 4e-98 6QAO-A nrPDB 350 8e-97 4I8P-A nrPDB 349 2e-96 3R31-A nrPDB 346 1e-95 4I8Q-A nrPDB 345 3e-95 4LIH-A nrPDB 334 5e-92 3JZ4-A nrPDB 312 2e-85 5KLK-A nrPDB 310 7e-85 4F3X-A nrPDB 306 1e-83 3I44-A nrPDB 305 2e-83 3U4J-A nrPDB 304 5e-83 3TY7-A nrPDB 304 7e-83 5J77-A nrPDB 302 3e-82 6MVR-A nrPDB 300 7e-82 4YWE-A nrPDB 300 1e-81 4JZ6-A nrPDB 296 1e-80 4U3W-A nrPDB 292 3e-79 4V6H-A nrPDB 290 1e-78 1WNB-A nrPDB 289 2e-78 3EK1-A nrPDB 288 3e-78 6C43-A nrPDB 288 5e-78 3B4W-A nrPDB 286 1e-77 5EUY-A nrPDB 284 7e-77 5UR2-A nrPDB 270 1e-72 2HG2-A nrPDB 270 1e-72 6FK3-A nrPDB 268 3e-72 3RJL-A nrPDB 266 1e-71 3QAN-A nrPDB 263 1e-70 3RH9-A nrPDB 259 1e-69 3R64-A nrPDB 258 3e-69 1T90-A nrPDB 255 3e-68 5VBF-A nrPDB 252 3e-67 5X5U-A nrPDB 251 4e-67 3RHD-A nrPDB 248 4e-66 2W8P-A nrPDB 244 7e-65 3K2W-A nrPDB 239 3e-63 2QE0-A nrPDB 236 2e-62 3PRL-A nrPDB 233 2e-61 2J5N-A nrPDB 230 1e-60 4DNG-A nrPDB 229 2e-60 5TJR-A nrPDB 221 4e-58 1UXV-A nrPDB 220 1e-57 3VZ0-A nrPDB 215 3e-56 4ZZ7-A nrPDB 213 2e-55 5N5S-A nrPDB 209 2e-54 3ROS-A nrPDB 209 2e-54 3VZ3-A nrPDB 209 3e-54 2JG7-A nrPDB 207 6e-54 3EFV-A nrPDB 205 5e-53 5KF0-A nrPDB 203 1e-52 4OGD-A nrPDB 202 2e-52 4X0T-A nrPDB 201 6e-52 4KNA-A nrPDB 200 1e-51 5JRY-A nrPDB 198 5e-51 4I3V-A nrPDB 197 1e-50 4PXN-A nrPDB 195 4e-50 5U0M-A nrPDB 189 3e-48 5J6B-A nrPDB 184 6e-47 4E4G-A nrPDB 181 4e-46 6DBB-A nrPDB 177 1e-44 4H7N-A nrPDB 174 1e-43 1AD3-A nrPDB 157 1e-38 5UCD-A nrPDB 154 8e-38 3SZA-A nrPDB 154 9e-38 4LGZ-A nrPDB 153 2e-37 3V9H-A nrPDB 152 2e-37 4OE4-A nrPDB 152 3e-37 3JU8-A nrPDB 152 5e-37 4QGK-A nrPDB 140 1e-33 4IDS-A nrPDB 122 3e-28 5NNO-A nrPDB 110 1e-24 2Y53-A nrPDB 87 1e-17 5DBV-A nrPDB 67 2e-11 3V4C-A nrPDB 56 4e-08 6D97-A nrPDB 51 1e-06 5UJU-A nrPDB 49 5e-06 3MY7-A nrPDB 47 3e-05 1EZ0-A nrPDB 44 1e-04 5J7I-A nrPDB 42 7e-04 5JFN-A nrPDB 41 0.002 3K9D-A nrPDB 39 0.004 2DQ3-A nrPDB 33 0.37 6MPQ-A nrPDB 31 1.4 5IJA-A nrPDB 30 1.7 6GAW-AL nrPDB 30 1.8 4UWM-A nrPDB 29 4.3 5ZLU-EE nrPDB 29 5.2 2YVA-A nrPDB 29 5.3 4N8G-A nrPDB 29 5.3 3KA0-A nrPDB 29 5.3 3M42-A nrPDB 29 6.1 2OZA-A nrPDB 29 6.2 2DLC-X nrPDB 28 6.7 1NY3-A nrPDB 28 6.9 >5AC2-A nrPDB Length = 501 Score = 1038 bits (2685), Expect = 0.0, Method: Compositional matrix adjust. Identities = 501/501 (100%), Positives = 501/501 (100%) Query: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV Sbjct: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60 Query: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL Sbjct: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120 Query: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI Sbjct: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180 Query: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID Sbjct: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240 Query: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG 300 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG Sbjct: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG 300 Query: 301 QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES 360 QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES Sbjct: 301 QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES 360 Query: 361 GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR 420 GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR Sbjct: 361 GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR 420 Query: 421 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE 480 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE Sbjct: 421 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE 480 Query: 481 YGFHEYTEVKTVTVKISQKNS 501 YGFHEYTEVKTVTVKISQKNS Sbjct: 481 YGFHEYTEVKTVTVKISQKNS 501 >5AC0-A nrPDB Length = 501 Score = 975 bits (2520), Expect = 0.0, Method: Compositional matrix adjust. Identities = 459/501 (91%), Positives = 485/501 (96%) Query: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60 MSSS PD+P LT+L+ +YTKIFINNEWH SVSGKKFPVFNPATEE+LC+VEEGDKEDV Sbjct: 1 MSSSAMPDVPAPLTNLQFKYTKIFINNEWHSSVSGKKFPVFNPATEEKLCEVEEGDKEDV 60 Query: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120 DKAVKAARQAFQIGSPWRTMDASERGRLL KLADLIERDRLLLATME+MNGGKL+SNAYL Sbjct: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLIERDRLLLATMEAMNGGKLFSNAYL 120 Query: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180 DL GCIKTLRYCAGWADKIQGRTIP+DGNFFTYTR EP+GVCGQIIPWNFPL+M +WKI Sbjct: 121 MDLGGCIKTLRYCAGWADKIQGRTIPMDGNFFTYTRSEPVGVCGQIIPWNFPLLMFLWKI 180 Query: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240 GPALSCGNTVVVKPAEQTPLTALH+ SLIKEAGFPPGVVNIVPGYGPTAGAAISSHMD+D Sbjct: 181 GPALSCGNTVVVKPAEQTPLTALHMGSLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVD 240 Query: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG 300 KVAFTGSTEVGKLIKEAAGKSNLKRV+LELGGKSPCIV ADADLDNAVEFAH GVFYHQG Sbjct: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVSLELGGKSPCIVFADADLDNAVEFAHQGVFYHQG 300 Query: 301 QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES 360 QCCIAASR+FVEESIYDEFVRRSVERAKKY+LGNPLTPGV+QGPQIDKEQY+KILDLIES Sbjct: 301 QCCIAASRLFVEESIYDEFVRRSVERAKKYVLGNPLTPGVSQGPQIDKEQYEKILDLIES 360 Query: 361 GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR 420 GKKEGAKLECGGGPWGNKGYF+QPTVFS+VTD+MRIAKEEIFGPVQQIMKFKSLDDVIKR Sbjct: 361 GKKEGAKLECGGGPWGNKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQIMKFKSLDDVIKR 420 Query: 421 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE 480 ANNTFYGLSAG+FT DIDKAIT+SSALQ+GTVWVNCY VVSAQCPFGGFKMSGNGRELGE Sbjct: 421 ANNTFYGLSAGIFTNDIDKAITVSSALQSGTVWVNCYSVVSAQCPFGGFKMSGNGRELGE 480 Query: 481 YGFHEYTEVKTVTVKISQKNS 501 YGFHEYTEVKTVT+KISQKNS Sbjct: 481 YGFHEYTEVKTVTIKISQKNS 501 >1O9J-A nrPDB Length = 501 Score = 894 bits (2310), Expect = 0.0, Method: Compositional matrix adjust. Identities = 416/501 (83%), Positives = 467/501 (93%) Query: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60 MSSSG PDLP LT++KIQ+TK+FINNEWH+SVSGK FPVFNPATEE++C+VEE DKEDV Sbjct: 1 MSSSGMPDLPAPLTNIKIQHTKLFINNEWHESVSGKTFPVFNPATEEKICEVEEADKEDV 60 Query: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120 DKAVKAAR+AFQ+GSPWRTMDASERG+L+YKLADLIERDRLLLAT+ES+N GK++++AYL Sbjct: 61 DKAVKAAREAFQMGSPWRTMDASERGQLIYKLADLIERDRLLLATLESINAGKVFASAYL 120 Query: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180 DL CIK LRYCAGWADKIQGRTIP+DG FF+YTRHEPIGVCG I PWN P+++L KI Sbjct: 121 MDLDYCIKALRYCAGWADKIQGRTIPVDGEFFSYTRHEPIGVCGLIFPWNAPMILLACKI 180 Query: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240 GPAL CGNTV+VKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMD+D Sbjct: 181 GPALCCGNTVIVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVD 240 Query: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG 300 KVAFTGSTEVGK+I+EAA KSNLKRVTLELG K+PCIV ADADLD+AVEFAH GVF +QG Sbjct: 241 KVAFTGSTEVGKMIQEAAAKSNLKRVTLELGAKNPCIVFADADLDSAVEFAHQGVFTNQG 300 Query: 301 QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES 360 Q CIAAS++FVEE+IYDEFV+RSVERAKKY+ GNPLTPGV GPQI+K Q++KI++LIES Sbjct: 301 QSCIAASKLFVEEAIYDEFVQRSVERAKKYVFGNPLTPGVNHGPQINKAQHNKIMELIES 360 Query: 361 GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR 420 GKKEGAKLECGGGPWGNKGYF+QPTVFSNVTD+MRIAKEEIFGPVQQIMKFKSLD+VIKR Sbjct: 361 GKKEGAKLECGGGPWGNKGYFIQPTVFSNVTDDMRIAKEEIFGPVQQIMKFKSLDEVIKR 420 Query: 421 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE 480 ANNT+YGL AGVFTKD+DKA+T+SSALQAGTVWVNCY SAQ P GGFKMSG+GRE+GE Sbjct: 421 ANNTYYGLVAGVFTKDLDKAVTVSSALQAGTVWVNCYLAASAQSPAGGFKMSGHGREMGE 480 Query: 481 YGFHEYTEVKTVTVKISQKNS 501 YG HEYTEVKTVT+KIS+KNS Sbjct: 481 YGIHEYTEVKTVTMKISEKNS 501 >4X2Q-A nrPDB Length = 504 Score = 777 bits (2006), Expect = 0.0, Method: Compositional matrix adjust. Identities = 360/492 (73%), Positives = 430/492 (87%) Query: 10 PVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQ 69 P +L+I+YTKIFINNEW +S SG+ FPV+NPAT E++C+V+E DK D+DKAV+AAR Sbjct: 13 PSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARL 72 Query: 70 AFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKT 129 AF +GS WR MDASERGRLL KLADL+ERDR +LATMES+NGGK + A+ DL G IKT Sbjct: 73 AFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKT 132 Query: 130 LRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNT 189 RY AGWADKI G TIP+DG++FT+TRHEPIGVCGQIIPWNFPL+M WKI PAL CGNT Sbjct: 133 FRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNT 192 Query: 190 VVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTE 249 VV+KPAEQTPL+AL++ +LIKEAGFPPGV+NI+PGYGPTAGAAI+SH+ IDK+AFTGSTE Sbjct: 193 VVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTE 252 Query: 250 VGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRI 309 VGKLI+EAAG+SNLKRVTLELGGKSP I+ ADADLD AVE AH GVF++QGQCC A SRI Sbjct: 253 VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRI 312 Query: 310 FVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLE 369 FVEESIY+EFVRRSVERAK+ ++G+P P QGPQIDK+QY+KIL+LI+SG EGAKLE Sbjct: 313 FVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLE 372 Query: 370 CGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLS 429 CGG G KG+F++PTVFSNVTD+MRIAKEEIFGPVQ+I++FK++D+VI+RANN+ +GL Sbjct: 373 CGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLV 432 Query: 430 AGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEV 489 A VFT DI+KA+T+SSA+QAGTVW+NCY ++AQ PFGGFKMSGNGRE+GE+G EY+EV Sbjct: 433 AAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEV 492 Query: 490 KTVTVKISQKNS 501 KTVTVKI QKNS Sbjct: 493 KTVTVKIPQKNS 504 >5FHZ-A nrPDB Length = 529 Score = 750 bits (1936), Expect = 0.0, Method: Compositional matrix adjust. Identities = 350/494 (70%), Positives = 419/494 (84%) Query: 7 PDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKA 66 P LP + +L++++TKIFINNEWH+S SGKKF NP+T E++C+VEEGDK DVDKAV+A Sbjct: 35 PALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEA 94 Query: 67 ARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGC 126 A+ AFQ GSPWR +DA RGRLL++LADL+ERDR LA +E+M+ GK + +A+ DL GC Sbjct: 95 AQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGC 154 Query: 127 IKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSC 186 I+TLRY AGWADKIQG+TIP D N +TRHEPIGVCG I PWNFPL+ML+WK+ PAL C Sbjct: 155 IRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCC 214 Query: 187 GNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTG 246 GNT+V+KPAEQTPLTAL++ SLIKEAGFPPGVVNIVPG+GPT GAAISSH I+K+AFTG Sbjct: 215 GNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTG 274 Query: 247 STEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAA 306 STEVGKL+KEAA +SNLKRVTLELGGK+PCIV ADADLD AVE AH GVF++QGQCC AA Sbjct: 275 STEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAA 334 Query: 307 SRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGA 366 SR+FVEE +Y EFVRRSVE AKK +G+P QGPQID++Q+DKIL+LIESGKKEGA Sbjct: 335 SRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGA 394 Query: 367 KLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFY 426 KLECGG +KG F++PTVFS VTD MRIAKEEIFGPVQ I+KFKS+++VIKRAN+T Y Sbjct: 395 KLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDY 454 Query: 427 GLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEY 486 GL+A VFTK++DKA+ ++SAL++GTVW+NCY + AQ PFGGFKMSGNGRELGEY EY Sbjct: 455 GLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEY 514 Query: 487 TEVKTVTVKISQKN 500 TEVKTVT+K+ KN Sbjct: 515 TEVKTVTIKLGDKN 528 >5L13-A nrPDB Length = 517 Score = 720 bits (1858), Expect = 0.0, Method: Compositional matrix adjust. Identities = 341/501 (68%), Positives = 408/501 (81%) Query: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60 +S++ T +P ++ +IFINNEWHD+VS K FP NP+T E +CQV EGDKEDV Sbjct: 17 LSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDV 76 Query: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120 DKAVKAAR AFQ+GSPWR MDAS RGRLL +LADLIERDR LA +E+++ GK Y +YL Sbjct: 77 DKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYL 136 Query: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180 DL +K LRY AGWADK G+TIPIDG+FF+YTRHEP+GVCGQIIPWNFPL+M WK+ Sbjct: 137 VDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKL 196 Query: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240 GPAL+ GN VV+K AEQTPLTAL+VA+LIKEAGFPPGVVNIVPG+GPTAGAAI+SH D+D Sbjct: 197 GPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVD 256 Query: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG 300 KVAFTGSTE+G++I+ AAG SNLKRVTLELGGKSP I+++DAD+D AVE AH +F++QG Sbjct: 257 KVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQG 316 Query: 301 QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES 360 QCC A SR FV+E IYDEFV RSV RAK ++GNP QGPQ+D+ Q+ KIL I + Sbjct: 317 QCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINT 376 Query: 361 GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR 420 GK+EGAKL CGGG ++GYF+QPTVF +V D M IAKEEIFGPV QI+KFK++++V+ R Sbjct: 377 GKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGR 436 Query: 421 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE 480 ANN+ YGL+A VFTKD+DKA +S ALQAGTVWVNCY V AQ PFGG+KMSG+GRELGE Sbjct: 437 ANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGE 496 Query: 481 YGFHEYTEVKTVTVKISQKNS 501 YG YTEVKTVTVK+ QKNS Sbjct: 497 YGLQAYTEVKTVTVKVPQKNS 517 >1AG8-A nrPDB Length = 499 Score = 711 bits (1834), Expect = 0.0, Method: Compositional matrix adjust. Identities = 334/499 (66%), Positives = 405/499 (81%) Query: 3 SSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDK 62 S+ T +P ++ Y +IFINNEWHD+VS K FP NP+T + +C V EGDK DVD+ Sbjct: 1 SAATQAVPTPNQQPEVLYNQIFINNEWHDAVSKKTFPTVNPSTGDVICHVAEGDKADVDR 60 Query: 63 AVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLND 122 AVKAAR AFQ+GSPWR MDASERGRLL +LADLIERDR LA +E+++ GK Y +YL D Sbjct: 61 AVKAARAAFQLGSPWRRMDASERGRLLNRLADLIERDRTYLAALETLDNGKPYIISYLVD 120 Query: 123 LAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGP 182 L +K LRY AGWADK G+TIPIDG++F+YTRHEP+GVCGQIIPWNFPL+M WK+GP Sbjct: 121 LDMVLKCLRYYAGWADKYHGKTIPIDGDYFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGP 180 Query: 183 ALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKV 242 AL+ GN VV+K AEQTPLTAL+VA+LIKEAGFPPGVVN++PG+GPTAGAAI+SH D+DKV Sbjct: 181 ALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNVIPGFGPTAGAAIASHEDVDKV 240 Query: 243 AFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQC 302 AFTGSTEVG LI+ AAGKSNLKRVTLE+GGKSP I+++DAD+D AVE AH +F++QGQC Sbjct: 241 AFTGSTEVGHLIQVAAGKSNLKRVTLEIGGKSPNIIMSDADMDWAVEQAHFALFFNQGQC 300 Query: 303 CIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGK 362 C A SR FV+E IY EFV RSV RAK ++GNP QGPQ+D+ Q+ K+L I+SGK Sbjct: 301 CCAGSRTFVQEDIYAEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKKVLGYIKSGK 360 Query: 363 KEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRAN 422 +EG KL CGGG ++GYF+QPTVF ++ D M IAKEEIFGPV QI+KFKS+++V+ RAN Sbjct: 361 EEGLKLLCGGGAAADRGYFIQPTVFGDLQDGMTIAKEEIFGPVMQILKFKSMEEVVGRAN 420 Query: 423 NTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYG 482 N+ YGL+A VFTKD+DKA +S ALQAGTVWVNCY V AQ PFGG+K+SG+GRELGEYG Sbjct: 421 NSKYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKLSGSGRELGEYG 480 Query: 483 FHEYTEVKTVTVKISQKNS 501 YTEVKTVTV++ QKNS Sbjct: 481 LQAYTEVKTVTVRVPQKNS 499 >4PXL-B nrPDB Length = 517 Score = 542 bits (1397), Expect = e-154, Method: Compositional matrix adjust. Identities = 252/495 (50%), Positives = 359/495 (72%), Gaps = 5/495 (1%) Query: 2 SSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVD 61 SS G+ ++P +++++TK+FI+ ++ D+VSGK F +P T E + + EGDK DVD Sbjct: 22 SSKGSFEVP----KVEVRFTKLFIDGKFVDAVSGKTFETRDPRTGEVIASIAEGDKADVD 77 Query: 62 KAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLN 121 AVKAAR+AF G PW M ERGR+L++ ADLI+ LA +++++ GKL++ Sbjct: 78 LAVKAAREAFDNG-PWPRMTGYERGRILHRFADLIDEHVEELAALDTVDAGKLFAVGKAR 136 Query: 122 DLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIG 181 D+ G LRY AG ADK+ G T+ + YT EP+GV G I+PWN+P M +K+G Sbjct: 137 DIPGAAHLLRYYAGAADKVHGATLKMAQRMHGYTLKEPVGVVGHIVPWNYPTTMFFFKVG 196 Query: 182 PALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDK 241 PAL+ G VVVKPAEQTPL+AL A L +EAG P GV+N+VPG+GPTAGAA+++HMD+DK Sbjct: 197 PALAAGCAVVVKPAEQTPLSALFYAHLAREAGVPAGVLNVVPGFGPTAGAAVAAHMDVDK 256 Query: 242 VAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQ 301 V+FTGSTEVG+L+ AA +SNLK V+LELGGKSP IV DADLD AV + + ++G+ Sbjct: 257 VSFTGSTEVGRLVMRAAAESNLKPVSLELGGKSPVIVFDDADLDMAVNLVNFATYTNKGE 316 Query: 302 CCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESG 361 C+A +RI+V+E IYDEFV+++ E A K ++G+P P V+QGPQ+DK+QY+K+L I+ G Sbjct: 317 ICVAGTRIYVQEGIYDEFVKKAAELASKSVVGDPFNPSVSQGPQVDKDQYEKVLRYIDIG 376 Query: 362 KKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRA 421 K+EGA L GG P G+KGY+++PT+F++V D+M IA++EIFGPV +MKFK++++VI++A Sbjct: 377 KREGATLVTGGKPCGDKGYYIEPTIFTDVKDDMTIAQDEIFGPVMALMKFKTVEEVIQKA 436 Query: 422 NNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEY 481 NNT YGL+AG+ TK+ID A T+S +++AG +W+NCY PFGG+KMSG G+++G Sbjct: 437 NNTRYGLAAGIVTKNIDVANTVSRSIRAGAIWINCYFAFDPDAPFGGYKMSGFGKDMGMD 496 Query: 482 GFHEYTEVKTVTVKI 496 +Y + KTV + Sbjct: 497 ALDKYLQTKTVVTPL 511 >4PZ2-A nrPDB Length = 534 Score = 514 bits (1324), Expect = e-146, Method: Compositional matrix adjust. Identities = 254/489 (51%), Positives = 344/489 (70%), Gaps = 5/489 (1%) Query: 12 LLTDL-KIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQA 70 LL D+ +I++TK+FIN + D+VSG+ F +P T + V E DKEDVD AV+AAR A Sbjct: 41 LLFDVPEIRFTKLFINGSFVDAVSGRTFDTRDPRTGGVIASVAEADKEDVDLAVRAARAA 100 Query: 71 FQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTL 130 F G W M SERGR++ +LADL+E LA +ES++ GK + D+ +L Sbjct: 101 FDHGE-WPRMSGSERGRIMARLADLVEEHAGELAALESLDAGKHPAVTRAVDVGNAAGSL 159 Query: 131 RYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTV 190 RY AG ADKI G T+ + G F +T EP+GV G IIPWNFP M K+ PAL+ G + Sbjct: 160 RYFAGAADKIHGETLKMPGQFQGHTLREPLGVAGVIIPWNFPSTMFAVKVAPALAAGCAL 219 Query: 191 VVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEV 250 VVKPAEQTPL+AL++A L K+AG P GV+N+VPG+GPTAGAA++SHMD+D V+FTGSTEV Sbjct: 220 VVKPAEQTPLSALYLAQLAKQAGVPDGVINVVPGFGPTAGAALASHMDVDMVSFTGSTEV 279 Query: 251 GKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIF 310 G+LI +A+ +SNLK V LELGGKSP IV DADLD AVE A F+++G+ C+AASR++ Sbjct: 280 GRLIMKASAESNLKPVYLELGGKSPLIVFDDADLDMAVELAVGASFFNKGEACVAASRVY 339 Query: 311 VEESIYDEFVRRSVERAKKYILGNPLT-PGVTQGPQIDKEQYDKILDLIESGKKEGAKLE 369 V+E +YD F R ER + +++G+P + P QGPQ+DK QY+++L I+ GK+EGA L Sbjct: 340 VQERVYDRFEERLAERMRSWVVGDPFSDPRADQGPQVDKAQYERVLSYIDHGKREGATLL 399 Query: 370 CGGGPWG--NKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYG 427 GG P KGY+++PTVF+NV ++M IAKEEIFGPV +MKFK++++ I RAN+T YG Sbjct: 400 TGGRPCAPEGKGYYIEPTVFTNVKEDMIIAKEEIFGPVMCLMKFKTVEEAIARANDTRYG 459 Query: 428 LSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYT 487 L AGV T+D+D A + +++AG VWVNCY + + CPFGG KMSG G++ G + +Y Sbjct: 460 LGAGVVTRDLDVANRVVRSVRAGVVWVNCYFAMGSDCPFGGRKMSGFGKDEGMHALDKYL 519 Query: 488 EVKTVTVKI 496 VK+V + Sbjct: 520 AVKSVVTPL 528 >5GT6-A nrPDB Length = 508 Score = 512 bits (1319), Expect = e-145, Method: Compositional matrix adjust. Identities = 258/496 (52%), Positives = 338/496 (68%), Gaps = 11/496 (2%) Query: 10 PVLLTDLKI---------QYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60 P+L T++++ + K+FIN E+ ++ GK F +NPATE+ L V E +ED+ Sbjct: 14 PMLKTNIELKPKVEAFLNEEIKMFINGEFVSAIGGKTFETYNPATEDVLAVVCEAQEEDI 73 Query: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120 D AVKAAR AF+ G PW M +ER L+YKLADLIE R LA +E+++ GK Y A Sbjct: 74 DAAVKAARSAFESG-PWAEMTTAERAHLIYKLADLIEEHREELAQLEALDNGKPYQVALD 132 Query: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180 +D++ ++ RY AGW KI G+TIPI ++ YTRHEP+GV GQIIPWNFPLVM WK+ Sbjct: 133 DDISATVENYRYYAGWTTKIIGQTIPISKDYLNYTRHEPVGVVGQIIPWNFPLVMSSWKM 192 Query: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240 G AL+ G T+V+KPAEQTPL+ L+ A L KEAGFP GVVN VPG+GP AGAAI +H DID Sbjct: 193 GAALATGCTIVLKPAEQTPLSLLYAAKLFKEAGFPNGVVNFVPGFGPEAGAAIVNHHDID 252 Query: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG 300 KVAFTGST GK I + + +K VTLELGGKSP I+L DADL+ A+ A G+ Y+ G Sbjct: 253 KVAFTGSTVTGKYIMRQSAEM-IKHVTLELGGKSPNIILEDADLEEAINGAFQGIMYNHG 311 Query: 301 QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES 360 Q C A SR+FV Y+ V V+ A LG + GP + K+Q +++L+ IE Sbjct: 312 QNCSAGSRVFVHRKHYETVVDALVKMANNVKLGAGMEKETEMGPLVSKKQQERVLNYIEQ 371 Query: 361 GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR 420 GKKEGA + GG KGYFV+PTVF++VTD+M I KEEIFGPV ++ F S ++VI+R Sbjct: 372 GKKEGATVAAGGERALEKGYFVKPTVFTDVTDDMTIVKEEIFGPVVVVLPFDSTEEVIER 431 Query: 421 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE 480 ANN+ YGL+AGV+T++I +++ L+AGTVW+N Y + +A PFGG+K SG GRELG Sbjct: 432 ANNSSYGLAAGVWTQNIKTGHQVANKLKAGTVWINDYNLENAAAPFGGYKQSGIGRELGS 491 Query: 481 YGFHEYTEVKTVTVKI 496 Y YTEVK+V V I Sbjct: 492 YALDNYTEVKSVWVNI 507 >3RHO-A nrPDB Length = 517 Score = 469 bits (1207), Expect = e-132, Method: Compositional matrix adjust. Identities = 236/484 (48%), Positives = 323/484 (66%), Gaps = 8/484 (1%) Query: 16 LKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGS 75 L++ Y ++FI E+ D+ K + NP +CQV DVDKAV AA++AF+ G Sbjct: 33 LQMPY-QLFIGGEFVDAEGSKTYNTINPTDGSVICQVSLAQVSDVDKAVAAAKEAFENGL 91 Query: 76 PWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAG 135 W ++A +RGRLLY+LAD++E+ + LAT+E+++ G +Y+ A + I+T RY AG Sbjct: 92 -WGKINARDRGRLLYRLADVMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAG 150 Query: 136 WADKIQGRTIPID----GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVV 191 W DKIQG TIPI+ T T+ EP+GVCG +IPWN+PL+ML WK L+ GNTVV Sbjct: 151 WCDKIQGATIPINQARPNRNLTLTKKEPVGVCGIVIPWNYPLMMLSWKTAACLAAGNTVV 210 Query: 192 VKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVG 251 +KPA+ TPLTAL A L +AG P GVVNI+PG G G +S H D+ K+ FTGSTEVG Sbjct: 211 IKPAQVTPLTALKFAELTLKAGIPKGVVNILPGSGSLVGQRLSDHPDVRKIGFTGSTEVG 270 Query: 252 KLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFV 311 K I ++ SN+K+V+L+LGGKSP I+ AD DL+ AV+ VF+++G+ CIAA R+FV Sbjct: 271 KHIMKSCALSNVKKVSLQLGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFV 330 Query: 312 EESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECG 371 EESI+++FV++ VE +K +GNPL GPQ + K+++ + G KEGA L CG Sbjct: 331 EESIHNQFVQKVVEEVEKMKIGNPLERDTNHGPQNHEAHLRKLVEYCQRGVKEGATLVCG 390 Query: 372 GGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFK--SLDDVIKRANNTFYGLS 429 G G+F QPTVF++V D M IAKEE FGP+ I +F +D V+ RAN T +GL+ Sbjct: 391 GNQVPRPGFFFQPTVFTDVEDHMYIAKEESFGPIMIISRFADGDVDAVLSRANATEFGLA 450 Query: 430 AGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEV 489 +GVFT+DI+KA+ +S LQAGTV++N Y PFGGFK SG G++LGE +EY + Sbjct: 451 SGVFTRDINKALYVSDKLQAGTVFINTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRI 510 Query: 490 KTVT 493 KTVT Sbjct: 511 KTVT 514 >4O6R-A nrPDB Length = 496 Score = 411 bits (1057), Expect = e-115, Method: Compositional matrix adjust. Identities = 208/480 (43%), Positives = 291/480 (60%), Gaps = 8/480 (1%) Query: 21 TKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80 T++FI+ + D+V V NP + ++ DVD AV AA +AF W M Sbjct: 11 TQLFIDGRFVDAVDRGTIDVLNPHDGSVITKIAAATAADVDLAVDAATRAF---PAWSAM 67 Query: 81 DASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI 140 A+ERGRLL +LAD IE + LA +ES++ G ++ D+ RY G ADK+ Sbjct: 68 PAAERGRLLLRLADAIEANTEALAQLESLDTGHPIRDSRALDVPRTAACFRYFGGMADKL 127 Query: 141 QGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200 QG IP+D F Y + PIGV GQI+PWNFPL+ WK+GPAL+ GNTVV+KP+E TPL Sbjct: 128 QGSVIPVDTGFLNYVQRAPIGVVGQIVPWNFPLMFTSWKMGPALAAGNTVVLKPSEITPL 187 Query: 201 TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGK 260 + L + L+ E GFP GVVNIVPGYG TAG ++ H + K+AFTGST G+ I EA+ + Sbjct: 188 STLRIVELMAEVGFPAGVVNIVPGYGHTAGQRLAEHPGVGKIAFTGSTATGRRIVEAS-Q 246 Query: 261 SNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFV 320 NLKRV LELGGK IV DA+LD A+ A +F++QGQ CIA SR+ + E I D F+ Sbjct: 247 GNLKRVQLELGGKGANIVFDDANLDAAINGAAWAIFHNQGQACIAGSRLVLHERIADAFL 306 Query: 321 RRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG----PWG 376 R V A +GNPL P GP K+ D++L ++ +++G ++ GG P Sbjct: 307 ERFVALASSIRIGNPLDPNTEMGPLTSKQHLDRVLSYVDVAREQGGRVLTGGSAPQDPAL 366 Query: 377 NKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKD 436 GY+V+PT+ R+A+EE+FGP +++F S D+ + AN T YGL +G++T D Sbjct: 367 ANGYYVRPTIVEAKHATDRVAQEEVFGPFVTVLRFGSDDEALAIANATEYGLGSGLWTND 426 Query: 437 IDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKI 496 + +A +++ + AG W+NCY V+ PFGG SG GRE+G H+YTE ++V V + Sbjct: 427 LSRAHRMAARIDAGMCWINCYKRVNPGSPFGGVGKSGYGREMGFEAMHDYTEARSVWVNV 486 >4QYJ-A nrPDB Length = 516 Score = 410 bits (1053), Expect = e-114, Method: Compositional matrix adjust. Identities = 215/482 (44%), Positives = 303/482 (62%), Gaps = 12/482 (2%) Query: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 ++ I +W + SGK V+NPAT + L +V +GD EDV+ AV++A + WR M Sbjct: 36 QMLIGGQWVSAQSGKTLNVYNPATGDILTEVPDGDVEDVNAAVESAAATLR-SDTWRRMP 94 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 S R R+L +LADL+E LA +E++N GKL + L ++ + LRY AGWA K+ Sbjct: 95 PSARERILLRLADLLEVHGDELARLETLNNGKLLIYSKLMEVGASAQWLRYMAGWATKLT 154 Query: 142 GRTI------PIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPA 195 G T+ P + T+ P+GV IIPWNFPL+M +WKI PAL+CGNTVV+KPA Sbjct: 155 GSTLDLSLPLPPEVRSRASTQRVPVGVVAAIIPWNFPLLMAVWKIAPALACGNTVVLKPA 214 Query: 196 EQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIK 255 E+TPLTAL +A L EAG P G +N+V G G TAG A+ H + KVAFTGSTEVG++I Sbjct: 215 EETPLTALRLAELAMEAGLPAGALNVVTGRGETAGDALVRHPKVAKVAFTGSTEVGRIIG 274 Query: 256 EAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESI 315 A G+S LK V+LELGGKSP IVLAD D A E A +F++ GQ C A SR++V ESI Sbjct: 275 SACGRS-LKAVSLELGGKSPVIVLADCDPQEAAEGAAAAIFFNHGQVCTAGSRLYVHESI 333 Query: 316 YDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGG--G 373 Y++ ++R + ++G+ L GV GP + K+ ++ +L I +G ++GA L CGG Sbjct: 334 YEDVIQRLAVIGESIVVGSGLEQGVHMGPMVSKKHHENVLRHIRNGIEDGADLICGGTEA 393 Query: 374 PWGNKGYFVQPTVFSNV-TDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGV 432 P +G+FV+PT+F+N ++R+ +E+FGPV F + +V+ AN + YGL A + Sbjct: 394 PCA-QGFFVKPTIFANREKKDIRLLSQEVFGPVLVATPFSDIAEVVNEANRSVYGLGASI 452 Query: 433 FTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492 +T D+ A+ I+ L+AGTVWVN + +V PFGGFK SG GRE G YT +++ Sbjct: 453 WTNDLSAALRINDELEAGTVWVNTHNMVDPNLPFGGFKDSGVGREHGAAAIEHYTTTRSL 512 Query: 493 TV 494 + Sbjct: 513 VI 514 >4O5H-A nrPDB Length = 511 Score = 403 bits (1035), Expect = e-112, Method: Compositional matrix adjust. Identities = 222/480 (46%), Positives = 296/480 (61%), Gaps = 8/480 (1%) Query: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 ++ I EW D+ SG++ V NPA + +V E D+ DV +AV AAR+AF G PWRT Sbjct: 32 QMLIGAEWSDAASGRQLDVVNPADGTVIARVPEADERDVQQAVAAARRAFDAG-PWRTAK 90 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 ++R RL+ LADLIE + LA +ES++ GK A D+A + RY AGWA KI+ Sbjct: 91 TTDRERLMLVLADLIEANARELAEIESLDNGKPVMVAQGLDVAMAAQCFRYMAGWATKIE 150 Query: 142 GRTIPI------DGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPA 195 G I D F YTR EP+GV G IIPWNFPL+M WKI PAL+ G TVV+KPA Sbjct: 151 GSVIDAGMPYLPDSEIFAYTRKEPVGVVGAIIPWNFPLLMAAWKIAPALATGCTVVLKPA 210 Query: 196 EQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIK 255 E TPL+AL + LI+ AGFP GVVNIV GYG TAGAA+S IDK+AFTGST+ GK I Sbjct: 211 EDTPLSALRLGELIQAAGFPDGVVNIVTGYGHTAGAALSRDPRIDKIAFTGSTQTGKTIG 270 Query: 256 EAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESI 315 AA N+ R++LELGGKSP IVL D DLD A + + +F++QGQ C A SR ++ + Sbjct: 271 HAA-LDNMTRMSLELGGKSPVIVLPDVDLDKAAQGVANAIFFNQGQVCTAGSRAYIHSKV 329 Query: 316 YDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPW 375 +D + R + A +G + P GP + +Q +++ I+SG EGA+ GG Sbjct: 330 FDGVIERVAKIAASLKIGPGMDPATQIGPLVSAKQRERVCGYIDSGFGEGARAAAGGRAI 389 Query: 376 GNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435 G+FV+PTV + T MR+ +EEIFGPV M F +D ++ AN+T YGL A +++ Sbjct: 390 DGPGFFVEPTVLVDTTQAMRVVREEIFGPVLVAMPFDDVDTAVQLANDTPYGLGASIWSN 449 Query: 436 DIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495 D+ + + AGTVWVNC+ ++ PFGG K SG GRELG +YTE K+V + Sbjct: 450 DLSAIHKLVPRIAAGTVWVNCHSLLDNALPFGGMKQSGFGRELGRAVIDQYTESKSVMMN 509 >6B4R-B nrPDB Length = 497 Score = 394 bits (1013), Expect = e-110, Method: Compositional matrix adjust. Identities = 209/499 (41%), Positives = 308/499 (61%), Gaps = 5/499 (1%) Query: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60 M++ D DLKI+ + F+N E+ ++ SG+ F +P L +V D D Sbjct: 1 MTTLTRADWEARAKDLKIE-GRAFVNGEYSNAASGETFDCLSPVDGRFLAKVASCDLADA 59 Query: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120 ++AVK AR AF G+ W + ++R + + + ADL+ + LA +E+++ GK S++ Sbjct: 60 EQAVKVARNAFDSGA-WSRLAPAKRKQTMIRFADLLLENAEELALLETLDMGKPISDSLH 118 Query: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180 D+A +LR+ A DKI EP+GV I+PWNFPL+M WK+ Sbjct: 119 IDVASAANSLRWSAEAIDKIYDEVAATPHAELGLVTREPVGVVAAIVPWNFPLLMSCWKL 178 Query: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240 GPAL+ GN+V++KP+E++PLTA+ +A L EAG P GV N++PGYG T G A++ HMD+D Sbjct: 179 GPALATGNSVILKPSEKSPLTAIRIAQLAVEAGIPKGVFNVLPGYGHTVGKALALHMDVD 238 Query: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADA-DLDNAVEFAHHGVFYHQ 299 + FTGST++ K + AG+SN+KRV LE GGKSP IV ADA DL A E A + ++Q Sbjct: 239 TLVFTGSTKIAKQLMVYAGESNMKRVWLEAGGKSPNIVFADAPDLKAAAEAAAGAIAFNQ 298 Query: 300 GQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIE 359 G+ C A SR+ VE SI D+F+ +E K + GNPL P G +D +Q + +L IE Sbjct: 299 GEVCTAGSRLLVERSIKDKFLPLVIEALKGWKPGNPLDPETNVGALVDTQQMNTVLSYIE 358 Query: 360 SGKKEGAKLECGGGPWGNK--GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDV 417 +G +GAKL GG + G +V+PT+F VT+ M+IA+EEIFGPV +++F+ ++ Sbjct: 359 AGHNDGAKLVAGGKRTLEETGGTYVEPTIFDGVTNAMKIAREEIFGPVLSVIEFEDAEEA 418 Query: 418 IKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRE 477 ++ AN+T YGL+A V+T ++ KA + AL+AG+VWVN Y PFGGFK SGNGR+ Sbjct: 419 VRIANDTPYGLAAAVWTSNLSKAHLTAKALRAGSVWVNQYDGGDMTAPFGGFKQSGNGRD 478 Query: 478 LGEYGFHEYTEVKTVTVKI 496 + F +YTE+K +K+ Sbjct: 479 KSLHAFDKYTELKATWIKL 497 >4GO4-A nrPDB Length = 495 Score = 394 bits (1013), Expect = e-110, Method: Compositional matrix adjust. Identities = 206/483 (42%), Positives = 301/483 (62%), Gaps = 9/483 (1%) Query: 21 TKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80 +++I+ + D+V+G V +P + ++ + DVD AV AA++AF W + Sbjct: 3 NQLYIDGRFVDAVAGGTIDVVSPHDGSLITRIAAAEAADVDLAVAAAKRAF---PAWSAL 59 Query: 81 DASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI 140 A+ERGRLL KLAD IE LA +ES+N G ++ D+ RY G ADKI Sbjct: 60 GAAERGRLLLKLADRIEECSEELAQLESLNTGHPIRDSRGLDVPRTAACFRYFGGMADKI 119 Query: 141 QGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200 +G IP+D F Y + +PIGV QI+PWNFPL+ WK+GPAL+ GNT+V+KP+E TPL Sbjct: 120 EGSVIPVDAGFLNYVQRKPIGVVAQIVPWNFPLMFTSWKMGPALAAGNTIVIKPSEITPL 179 Query: 201 TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGK 260 + L + L+ E GFP GVVN+VPGYG TAG A++ H+D+ K+AFTGST G+ I EA+ K Sbjct: 180 STLRIVELMTEVGFPKGVVNVVPGYGHTAGQALAEHLDVGKIAFTGSTATGRRIVEAS-K 238 Query: 261 SNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFV 320 SNLKR+ LELGGK IV DA+++ AV A +F++QGQ CIA SR+ + + I D+F+ Sbjct: 239 SNLKRIQLELGGKGANIVFEDANIEAAVNGAAWAIFHNQGQACIAGSRLILHKDIADQFL 298 Query: 321 RRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNK-- 378 R + AK LG+P+ P GP + D++L I+ ++G K+ GG +K Sbjct: 299 ERFIALAKSIRLGDPMDPETEMGPLTSALRRDRVLSYIDIAIEQGGKVLAGGKAPDDKAL 358 Query: 379 --GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKD 436 G++V+PTV + R+ +EE+FGP +++F S ++ + ANNT YGL +G++T++ Sbjct: 359 ANGFYVEPTVV-EAKPQDRVCQEEVFGPFVTVVRFSSDEEALAIANNTEYGLGSGLWTQN 417 Query: 437 IDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKI 496 + +A ++ A+ AG W+NCY VS PFGG SG GRE+G H+YTE ++V V + Sbjct: 418 LARAHKMAHAIHAGMCWINCYKRVSPGSPFGGVGQSGYGREMGFEAIHDYTEARSVWVNV 477 Query: 497 SQK 499 K Sbjct: 478 DAK 480 >5IUV-A nrPDB Length = 497 Score = 384 bits (985), Expect = e-107, Method: Compositional matrix adjust. Identities = 202/485 (41%), Positives = 298/485 (61%), Gaps = 5/485 (1%) Query: 15 DLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIG 74 +LKI+ + FI E+ + SG+ F +P L +V D D +AV++AR AF G Sbjct: 15 NLKIE-GRAFIQGEYTAAASGETFDCISPVDGRLLAKVASCDAADAQRAVESARSAFDSG 73 Query: 75 SPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCA 134 + W + ++R + + A L+E++ LA +E+++ GK S++ D+ G + L + Sbjct: 74 A-WSRLAPAKRKATMIRFAGLLEQNAEELALLETLDMGKPISDSLGVDIPGGARALSWSG 132 Query: 135 GWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKP 194 DK+ + EP+GV I+PWNFPL+M WK+GPALS GN+VV+KP Sbjct: 133 EAIDKLYDEVAATPHDQLGLVTREPVGVVAAIVPWNFPLMMACWKLGPALSTGNSVVLKP 192 Query: 195 AEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLI 254 +E++PLTA+ +A L EAG P GV+N++PGYG T G A++ HMD+D V FTGST++ K + Sbjct: 193 SEKSPLTAIRIAQLAIEAGIPAGVLNVLPGYGHTVGKALALHMDVDTVVFTGSTKIAKQL 252 Query: 255 KEAAGKSNLKRVTLELGGKSPCIVLADA-DLDNAVEFAHHGVFYHQGQCCIAASRIFVEE 313 AG+SN+KRV LE GGKSP IV ADA DL A + A + ++QG+ C A SR+ VE Sbjct: 253 MIYAGESNMKRVWLEAGGKSPNIVFADAPDLQAAADSAASAIAFNQGEVCTAGSRLLVER 312 Query: 314 SIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG 373 SI D F+ +E + GNPL P G +D +Q + +L I +G +GA+L GG Sbjct: 313 SIKDRFLPMVIEALGTWKPGNPLDPATNVGALVDTQQMNTVLSYIAAGHTDGARLVAGGK 372 Query: 374 PWGNK--GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAG 431 + G +V+PT+F V + MRIA+EEIFGPV ++ F + ++ I+ AN+T YGL+A Sbjct: 373 QILQETGGTYVEPTIFDGVNNAMRIAQEEIFGPVLSVLTFDTAEEAIQIANDTPYGLAAA 432 Query: 432 VFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKT 491 V+T ++ KA + AL+AG+VWVN Y PFGGFK SGNGR+ + F +YTE+K+ Sbjct: 433 VWTANLSKAHLTARALRAGSVWVNQYDGGDMTAPFGGFKQSGNGRDKSLHAFDKYTELKS 492 Query: 492 VTVKI 496 +K+ Sbjct: 493 TWIKL 497 >4V3F-A nrPDB Length = 497 Score = 380 bits (976), Expect = e-106, Method: Compositional matrix adjust. Identities = 203/491 (41%), Positives = 290/491 (59%), Gaps = 15/491 (3%) Query: 18 IQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPW 77 I ++FI+ EW + + + PV NP+TEE + + EDV+ AV AAR+AF+ + W Sbjct: 5 IPARQLFIDGEWREPIKKNRIPVINPSTEEIIGDIPAATAEDVEVAVVAARRAFRRNN-W 63 Query: 78 RTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLN--DLAGCIKTLRYCAG 135 + R L +A I + +E+++ GK + A L+ D+A C Y AG Sbjct: 64 SATSGAHRATYLRAIAAKITEKKDHFVKLETIDSGKPFDEAVLDIDDVASC---FEYFAG 120 Query: 136 WADKIQGR-----TIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTV 190 A+ + G+ T+P++ F ++ +P+GV G I PWN+PL+M WKI PAL+ G T Sbjct: 121 QAEALDGKQKAPVTLPME-RFKSHVLRQPLGVVGLISPWNYPLLMATWKIAPALAAGCTA 179 Query: 191 VVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEV 250 V+KP+E +T L + E G PPGV+NI+ G GP AGA + SH D+DK+AFTGS+ Sbjct: 180 VLKPSELASVTCLEFGEVCNEVGLPPGVLNILTGLGPDAGAPLVSHPDVDKIAFTGSSAT 239 Query: 251 GKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIF 310 G + +A + +K VTLELGGKSP +V D D+D VE+ G F+ GQ C A SR+ Sbjct: 240 GSKVMASAAQL-VKPVTLELGGKSPIVVFEDVDIDKVVEWTIFGCFWTNGQICSATSRLL 298 Query: 311 VEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLEC 370 V ESI EFV + V+ K + +P G GP I K QYDKI+ I + K EGA + Sbjct: 299 VHESIAAEFVDKLVKWTKNIKISDPFEEGCRLGPVISKGQYDKIMKFISTAKSEGATILY 358 Query: 371 GGGPWGN--KGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGL 428 GG + KGY+++PT+ ++++ M+I KEE+FGPV + F S D+ I AN+T YGL Sbjct: 359 GGSRPEHLKKGYYIEPTIVTDISTSMQIWKEEVFGPVLCVKTFSSEDEAIALANDTEYGL 418 Query: 429 SAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTE 488 +A VF+ D+++ I+ AL+ G VWVNC Q P+GG K SG GRELGE+G Y Sbjct: 419 AAAVFSNDLERCERITKALEVGAVWVNCSQPCFVQAPWGGIKRSGFGRELGEWGIQNYLN 478 Query: 489 VKTVTVKISQK 499 +K VT IS + Sbjct: 479 IKQVTQDISDE 489 >1BPW-A nrPDB Length = 503 Score = 378 bits (970), Expect = e-105, Method: Compositional matrix adjust. Identities = 194/469 (41%), Positives = 284/469 (60%), Gaps = 12/469 (2%) Query: 39 PVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIER 98 PVF PAT LCQ+ E+VD+AV++A+ A+ W M ER R++ + A +I Sbjct: 39 PVFEPATGRVLCQMVPCGAEEVDQAVQSAQAAYL---KWSKMAGIERSRVMLEAARIIRE 95 Query: 99 DRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHE 158 R +A +E +N GK + A D+ + + Y AG A + G+ I + G F YTR E Sbjct: 96 RRDNIAKLEVINNGKTITEAEY-DIDAAWQCIEYYAGLAPTLSGQHIQLPGGAFAYTRRE 154 Query: 159 PIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGV 218 P+GVC I+ WN+P ++ WK PAL+CGN VV KP+ TP+T + +A + EAG P G+ Sbjct: 155 PLGVCAGILAWNYPFMIAAWKCAPALACGNAVVFKPSPMTPVTGVILAEIFHEAGVPVGL 214 Query: 219 VNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIV 278 VN+V G G G+ + H ++ KV+FTGS GK + E + K+ +K VTLELGGKSP ++ Sbjct: 215 VNVVQG-GAETGSLLCHHPNVAKVSFTGSVPTGKKVMEMSAKT-VKHVTLELGGKSPLLI 272 Query: 279 LADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTP 338 D +L+NAV A F QGQ C +R+FV+ I +F+ V+R K ++G+PL Sbjct: 273 FKDCELENAVRGALMANFLTQGQVCTNGTRVFVQREIMPQFLEEVVKRTKAIVVGDPLLT 332 Query: 339 GVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG------NKGYFVQPTVFSNVTD 392 G I K Q DK+L + KKEGA++ CGG P GYF+ P V N D Sbjct: 333 ETRMGGLISKPQLDKVLGFVAQAKKEGARVLCGGEPLTPSDPKLKNGYFMSPCVLDNCRD 392 Query: 393 EMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTV 452 +M KEEIFGPV ++ F + ++V++RANNT +GL++GVFT+DI +A +++ L+AGT Sbjct: 393 DMTCVKEEIFGPVMSVLPFDTEEEVLQRANNTTFGLASGVFTRDISRAHRVAANLEAGTC 452 Query: 453 WVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKNS 501 ++N Y + + PFGG+KMSG GRE G+ Y+++KTV V++ +S Sbjct: 453 YINTYSISPVEVPFGGYKMSGFGRENGQATVDYYSQLKTVIVEMGDVDS 501 >3IWJ-A nrPDB Length = 503 Score = 376 bits (965), Expect = e-104, Method: Compositional matrix adjust. Identities = 208/496 (41%), Positives = 296/496 (59%), Gaps = 16/496 (3%) Query: 15 DLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAF--Q 72 D+ I ++FIN +W V K+ PV NPAT+ + + KEDVD AV AA+ A Sbjct: 2 DIPIPTRQLFINGDWKAPVLNKRIPVINPATQNIIGDIPAATKEDVDVAVAAAKTALTRN 61 Query: 73 IGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAY--LNDLAGCIKTL 130 G+ W T + R R L +A + + LA +ES++ GK A ++D+AGC Sbjct: 62 KGADWATASGAVRARYLRAIAAKVTEKKPELAKLESIDCGKPLDEAAWDIDDVAGC---F 118 Query: 131 RYCAGWADKIQGR-----TIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALS 185 Y A A+K+ R ++P+D F ++ EPIGV G I PWN+P++M WK+ PAL+ Sbjct: 119 EYYADLAEKLDARQKAPVSLPMD-TFKSHVLREPIGVVGLITPWNYPMLMATWKVAPALA 177 Query: 186 CGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFT 245 G ++KP+E LT L + + KE G PPGV+NI+ G GP AGA +++H D+DKVAFT Sbjct: 178 AGCAAILKPSELASLTCLELGEICKEVGLPPGVLNILTGLGPEAGAPLATHPDVDKVAFT 237 Query: 246 GSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIA 305 GS+ G I AA + +K V+LELGGKSP +V D DLD A E+A G F+ GQ C A Sbjct: 238 GSSATGSKIMTAAAQL-VKPVSLELGGKSPLVVFEDVDLDKAAEWAIFGCFWTNGQICSA 296 Query: 306 ASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEG 365 SR+ + ESI EF+ R V+ K + +PL G GP + + QY+KIL + + K EG Sbjct: 297 TSRLILHESIATEFLNRIVKWIKNIKISDPLEEGCRLGPVVSEGQYEKILKFVSNAKSEG 356 Query: 366 AKLECGGGPWGN--KGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANN 423 A + GG + KG+F++PT+ ++VT M+I +EE+FGPV + F + ++ I AN+ Sbjct: 357 ATILTGGSRPEHLKKGFFIEPTIITDVTTNMQIWREEVFGPVLCVKTFSTEEEAIDLAND 416 Query: 424 TFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGF 483 T YGL A V + D+++ ++ A +AG VWVNC Q P+GG K SG GRELGE+G Sbjct: 417 TVYGLGAAVISNDLERCERVTKAFKAGIVWVNCSQPCFTQAPWGGVKRSGFGRELGEWGL 476 Query: 484 HEYTEVKTVTVKISQK 499 Y VK VT IS++ Sbjct: 477 DNYLSVKQVTQYISEE 492 >4CAZ-A nrPDB Length = 490 Score = 370 bits (951), Expect = e-103, Method: Compositional matrix adjust. Identities = 190/485 (39%), Positives = 282/485 (58%), Gaps = 9/485 (1%) Query: 17 KIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSP 76 + + K++I + ++ SG F NPA E L +V+ +EDV++AV++A + ++ Sbjct: 3 RFEEQKLYIGGRYVEASSGATFETINPANGEVLAKVQRASREDVERAVQSAVEGQKV--- 59 Query: 77 WRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGW 136 W M A +R R+L + D++ LA +E+++ GK + D+ L Y AG Sbjct: 60 WAAMTAMQRSRILRRAVDILRERNDELAALETLDTGKPLAETRSVDIVTGADVLEYYAGL 119 Query: 137 ADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAE 196 I+G IP+ F YTR EP+GV I WN+P+ + +WK PAL+ GN ++ KP+E Sbjct: 120 VPAIEGEQIPLRETSFVYTRREPLGVVAGIGAWNYPVQIALWKSAPALAAGNAMIFKPSE 179 Query: 197 QTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKE 256 TPLTAL +A + EAG P GV N++ G G G ++ H I+K++FTG T GK + Sbjct: 180 VTPLTALKLAEIYTEAGVPDGVFNVLTGSGREVGQWLTEHPLIEKISFTGGTSTGKKVMA 239 Query: 257 AAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY 316 +A S+LK VT+ELGGKSP I+ DADLD A + A F+ GQ C +R+F+ S Sbjct: 240 SASSSSLKEVTMELGGKSPLIIFPDADLDRAADIAVMANFFSSGQVCTNGTRVFIHRSQQ 299 Query: 317 DEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGG---- 372 F + +ER ++ LG+P GP + + +L IESGK + A+L CGG Sbjct: 300 ARFEAKVLERVQRIRLGDPQDENTNFGPLVSFPHMESVLGYIESGKAQKARLLCGGERVT 359 Query: 373 -GPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAG 431 G +G KG +V PTVF++ D+M I +EEIFGPV I+ + D+ I+RAN+T YGL+AG Sbjct: 360 DGAFG-KGAYVAPTVFTDCRDDMTIVREEIFGPVMSILVYDDEDEAIRRANDTEYGLAAG 418 Query: 432 VFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKT 491 V T+D+ +A L+AG W+N +G A+ P GG+K SG GRE G YT +K+ Sbjct: 419 VVTQDLARAHRAIHRLEAGICWINTWGESPAEMPVGGYKQSGVGRENGLTTLAHYTRIKS 478 Query: 492 VTVKI 496 V V++ Sbjct: 479 VQVEL 483 >2D4E-A nrPDB Length = 515 Score = 369 bits (948), Expect = e-102, Method: Compositional matrix adjust. Identities = 199/482 (41%), Positives = 296/482 (61%), Gaps = 15/482 (3%) Query: 24 FINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDAS 83 FI E+ S SG+ FP +PAT E L G + +VD+A KAA +AFQ W A Sbjct: 30 FIAGEFVPSESGETFPSLDPATNEVLGVAARGGEREVDRAAKAAHEAFQR---WSRTKAK 86 Query: 84 ERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADK-IQG 142 ER R L ++A+LIE+ LA ME ++ G++ +A + + A +A+ ++ Sbjct: 87 ERKRYLLRIAELIEKHADELAVMECLDAGQVL-RIVRAQVARAAENFAFYAEYAEHAMED 145 Query: 143 RTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTA 202 RT P+D ++ YT P G G I PWN PL++ W+I PAL+ GNTVV+KPAE +P TA Sbjct: 146 RTFPVDRDWLYYTVRVPAGPVGIITPWNAPLMLSTWRIAPALAFGNTVVLKPAEWSPFTA 205 Query: 203 LHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSN 262 +A ++KEA PPGV N+V G+G AGAA+ +H + + TG TE GK++ A + Sbjct: 206 TKLAEILKEADLPPGVFNLVQGFGEEAGAALVAHPLVPLLTLTGETETGKIVMRNAA-DH 264 Query: 263 LKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRR 322 LKR++ ELGGKSP +V ADADL+ A++ +F G+ C A+SR+ VEE I+++FV + Sbjct: 265 LKRLSPELGGKSPALVFADADLERALDAVVFQIFSFNGERCTASSRLLVEEKIFEDFVGK 324 Query: 323 SVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGG--------GP 374 VERA+ +G+PL P GP I E ++L +E+GK+EGA+L GG G Sbjct: 325 VVERARAIRVGHPLDPETEVGPLIHPEHLQRVLGYVEAGKREGARLLVGGERAKTSFRGE 384 Query: 375 WGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFT 434 ++G ++ PTVF + M+IA+EEIFGPV + FK ++ +++AN+T YGL+A VFT Sbjct: 385 DLSRGNYLLPTVFVG-ENHMKIAQEEIFGPVLVAIPFKDEEEALRKANDTKYGLAAYVFT 443 Query: 435 KDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTV 494 +D+++A ++ L+AG V++N + V PFGG K SG+ RE G Y YT++KT+ + Sbjct: 444 RDLERAHRLALELEAGMVYLNSHNVRHLPTPFGGVKGSGDRREGGTYALDFYTDLKTIAL 503 Query: 495 KI 496 + Sbjct: 504 PL 505 >3IWK-A nrPDB Length = 503 Score = 358 bits (918), Expect = 3e-99, Method: Compositional matrix adjust. Identities = 200/487 (41%), Positives = 283/487 (58%), Gaps = 12/487 (2%) Query: 16 LKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAF--QI 73 + + ++FI+ EW + K+ P NP+TE + + KEDVD AV AA++A + Sbjct: 3 ITVSSRQLFIDGEWRVPILNKRIPNINPSTENIIGDIPAATKEDVDLAVDAAKRAISRKN 62 Query: 74 GSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYC 133 G W S R R L +A I+ + L +ES++ GK A L DL + Y Sbjct: 63 GRDWSAASGSLRARYLRAIAAKIKEKKDELGKLESIDCGKPLEEA-LADLDDVVACFEYY 121 Query: 134 AGWADKIQGR-----TIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGN 188 AG A+++ + ++P+D F +Y EPIGV I PWN+P +M WKI PAL+ G Sbjct: 122 AGLAEELDSKQKAPISLPMD-TFKSYILKEPIGVVALITPWNYPFLMATWKIAPALAAGC 180 Query: 189 TVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGST 248 ++KP+E +T L + + KE G P GV+NIV G G AGA+++SH D+DK++FTGS+ Sbjct: 181 AAILKPSELASVTCLELGEICKEVGLPRGVLNIVTGLGHEAGASLASHPDVDKISFTGSS 240 Query: 249 EVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASR 308 G I A + +K V+LELGGKSP +V D DLD E+ G F+ GQ C A SR Sbjct: 241 ATGSKIMTTAAQL-VKPVSLELGGKSPIVVFEDVDLDKVAEWTVFGCFFTNGQICSATSR 299 Query: 309 IFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKL 368 + V ESI EFV + V+ A+ + +PL G GP + + QY K+L+ I S K EGA + Sbjct: 300 LIVHESIAVEFVDKLVKWAENIKISDPLEEGCRLGPIVSEAQYKKVLNCISSAKSEGATI 359 Query: 369 ECGGG--PWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFY 426 GG KGYFV+PT+ ++VT M+I +EE+FGPV + F + ++ I AN+T Y Sbjct: 360 LTGGRRPEHLKKGYFVEPTIITDVTTSMQIWREEVFGPVLAVKTFSTEEEAINLANDTHY 419 Query: 427 GLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEY 486 GL + V + D+++ +S ALQAG VW+NC Q P+GG K SG GRELGE+G Y Sbjct: 420 GLGSAVMSNDLERCERLSKALQAGIVWINCAQPSFIQAPWGGIKRSGFGRELGEWGLENY 479 Query: 487 TEVKTVT 493 VK VT Sbjct: 480 LSVKQVT 486 >4MPY-A nrPDB Length = 520 Score = 354 bits (909), Expect = 4e-98, Method: Compositional matrix adjust. Identities = 194/477 (40%), Positives = 278/477 (58%), Gaps = 10/477 (2%) Query: 16 LKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGS 75 LK + +I+ EW +S + + NP +E + V EG KED ++A+ AAR+AF+ G Sbjct: 28 LKHLSQRQYIDGEWVESANKNTRDIINPYNQEVIFTVSEGTKEDAERAILAARRAFESGE 87 Query: 76 PWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAG 135 W A RG+ + +AD I+ R LA +E+++ GK +Y D+ Y AG Sbjct: 88 -WSQETAETRGKKVRAIADKIKEHREALARLETLDTGKTLEESYA-DMDDIHNVFMYFAG 145 Query: 136 WADKIQGRTI--PIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVK 193 ADK G I PI + EP+GV QI PWN+PL+ WKI PAL+ G ++V+K Sbjct: 146 LADKDGGEMIDSPIPDTESKIVK-EPVGVVTQITPWNYPLLQASWKIAPALATGCSLVMK 204 Query: 194 PAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKL 253 P+E TPLT + V L++E GFP G +N++ G G G +S H ++D V+FTG E GK Sbjct: 205 PSEITPLTTIRVFELMEEVGFPKGTINLILGAGSEVGDVMSGHKEVDLVSFTGGIETGKH 264 Query: 254 IKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEE 313 I + A +N+ + LELGGK+P I+ DAD + AV+ A +G ++H GQ C A SRI V+ Sbjct: 265 IMKNAA-NNVTNIALELGGKNPNIIFDDADFELAVDQALNGGYFHAGQVCSAGSRILVQN 323 Query: 314 SIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG 373 SI D+F + ++R KK LGN GP I E +KI ++ K EGA + GG Sbjct: 324 SIKDKFEQALIDRVKKIKLGNGFDADTEMGPVISTEHRNKIESYMDVAKAEGATIAVGGK 383 Query: 374 PWGNK----GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLS 429 G F +PTV +N MRI +EE+FGPV + F++ + I+ AN++ YGL+ Sbjct: 384 RPDRDDLKDGLFFEPTVITNCDTSMRIVQEEVFGPVVTVEGFETEQEAIQLANDSIYGLA 443 Query: 430 AGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEY 486 VF+KDI KA +++ L+ GTVW+N + AQ P+GG+K SG GRELG+ G EY Sbjct: 444 GAVFSKDIGKAQRVANKLKLGTVWINDFHPYFAQAPWGGYKQSGIGRELGKEGLEEY 500 >6QAO-A nrPDB Length = 508 Score = 350 bits (898), Expect = 8e-97, Method: Compositional matrix adjust. Identities = 190/467 (40%), Positives = 276/467 (59%), Gaps = 12/467 (2%) Query: 41 FNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDR 100 F PAT + +++V+ AV+ A+ AF+I W ER R+L + A +I Sbjct: 46 FEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKSGMERCRILLEAARIIRERE 102 Query: 101 LLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPI 160 +ATME +N GK A L D+ + L Y AG A + G I + G F YTR EP+ Sbjct: 103 DEIATMECINNGKSIFEARL-DIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPL 161 Query: 161 GVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVN 220 GVC I WN+P + WK PAL+CGN +V KP+ TP++AL +A + EAG PPG+ N Sbjct: 162 GVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFN 221 Query: 221 IVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLA 280 +V G G G + H D+ KV+FTGS G I E + K +K VTLELGGKSP I+ + Sbjct: 222 VVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK-GIKPVTLELGGKSPLIIFS 279 Query: 281 DADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGV 340 D D++NAV+ A F QGQ C +R+FV++ I D+F V++ ++ +G+PL Sbjct: 280 DCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDT 339 Query: 341 TQGPQIDKEQYDKILDLIESGKKEGAKLECGGG------PWGNKGYFVQPTVFSNVTDEM 394 GP I++ +++L ++ K++GAK+ CGG P GY+++P V +N D+M Sbjct: 340 RMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDM 399 Query: 395 RIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWV 454 KEEIFGPV I+ F + +V++RAN+T +GL+AGVFT+DI +A + + LQAGT ++ Sbjct: 400 TCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFI 459 Query: 455 NCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKNS 501 N Y V + PFGG+K SG GRE G Y+++KTV V++ S Sbjct: 460 NNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVES 506 >4I8P-A nrPDB Length = 520 Score = 349 bits (895), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 203/490 (41%), Positives = 286/490 (58%), Gaps = 10/490 (2%) Query: 18 IQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQI--GS 75 + ++F++ EW G++ PV NP TE + ++ G EDVD AV AAR A + G Sbjct: 22 VPLRQLFVDGEWRPPAQGRRLPVVNPTTEAHIGEIPAGTAEDVDAAVAAARAALKRNRGR 81 Query: 76 PWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAY--LNDLAGCIKTLRYC 133 W + R + L +A + + LA +E+++ GK Y A ++D+AGC + Sbjct: 82 DWARAPGAVRAKYLRAIAAKVIERKPELAKLEALDCGKPYDEAAWDMDDVAGCFEYFADQ 141 Query: 134 AGWADKIQGR--TIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVV 191 A DK Q ++P++ F + R EPIGV G I PWN+PL+M WKI PAL+ G T V Sbjct: 142 AEALDKRQNSPVSLPME-TFKCHLRREPIGVVGLITPWNYPLLMATWKIAPALAAGCTAV 200 Query: 192 VKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVG 251 +KP+E +T L +A + KE G P GV+NIV G GP AGA +S+H D+DKVAFTGS E G Sbjct: 201 LKPSELASVTCLELADICKEVGLPSGVLNIVTGLGPDAGAPLSAHPDVDKVAFTGSFETG 260 Query: 252 KLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFV 311 K I A+ +K VTLELGGKSP +V D D+D AVE+ G F+ GQ C A SR+ + Sbjct: 261 KKIM-ASAAPMVKPVTLELGGKSPIVVFDDVDIDKAVEWTLFGCFWTNGQICSATSRLLI 319 Query: 312 EESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECG 371 I +F R V AK + +PL G GP + + QY+KI I + K +GA + G Sbjct: 320 HTKIAKKFNERMVAWAKNIKVSDPLEEGCRLGPVVSEGQYEKIKKFISNAKSQGATILTG 379 Query: 372 GGPWGN--KGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLS 429 G + KG+F++PT+ +++T M I +EE+FGPV + +F + D+ I+ AN+T YGL+ Sbjct: 380 GVRPAHLEKGFFIEPTIITDITTSMEIWREEVFGPVLCVKEFSTEDEAIELANDTQYGLA 439 Query: 430 AGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEV 489 V + D ++ +S + AG +WVNC Q P+GG K SG GRELGE G Y V Sbjct: 440 GAVISGDRERCQRLSEEIDAGCIWVNCSQPCFCQAPWGGNKRSGFGRELGEGGIDNYLSV 499 Query: 490 KTVTVKISQK 499 K VT IS + Sbjct: 500 KQVTEYISDE 509 >3R31-A nrPDB Length = 517 Score = 346 bits (888), Expect = 1e-95, Method: Compositional matrix adjust. Identities = 194/495 (39%), Positives = 282/495 (56%), Gaps = 11/495 (2%) Query: 12 LLTDLKIQ-YTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQA 70 + T LK Q FI+ ++ + +G F PAT E + ++ V++A+ +A++A Sbjct: 5 IATPLKAQPKASHFIDGDYVEDNTGTPFESIFPATGEMIAKLHAATPAIVERAIASAKRA 64 Query: 71 FQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTL 130 + W M RGR+L + AD++ L+T+E+++ GK + D Sbjct: 65 QK---EWAAMSPMARGRILKRAADIMRERNDALSTLETLDTGKPIQETIVADPTSGADAF 121 Query: 131 RYCAGWA-DKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNT 189 + G A + G IP+ G+F YT+ P+GVC I WN+P + WK PAL GN Sbjct: 122 EFFGGIAPSALNGDYIPLGGDF-AYTKRVPLGVCVGIGAWNYPQQIACWKAAPALVAGNA 180 Query: 190 VVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTE 249 +V KP+E TPL AL +A ++ EAG P G+ N++ G T G + +H D+ KV+ TGS Sbjct: 181 MVFKPSENTPLGALKIAEILIEAGLPKGLFNVIQGDRDT-GPLLVNHPDVAKVSLTGSVP 239 Query: 250 VGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRI 309 G+ + AA +LK VT+ELGGKSP IV DAD+++AV A G FY GQ C +R+ Sbjct: 240 TGRKVA-AAAAGHLKHVTMELGGKSPMIVFDDADIESAVGGAMLGNFYSSGQVCSNGTRV 298 Query: 310 FVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLE 369 FV++ F+ R + ILG+PL GP + K Q +K+L IE GK EGA L Sbjct: 299 FVQKKAKARFLENLKRRTEAMILGDPLDYATHLGPLVSKAQQEKVLSYIEKGKAEGATLI 358 Query: 370 CGGGPWGN---KGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFY 426 GGG N +G +VQPTVF++VTD+M IA+EEIFGPV ++ F D+V+ RAN T + Sbjct: 359 TGGGIPNNVAGEGAYVQPTVFADVTDDMTIAREEIFGPVMCVLDFDDEDEVLARANATEF 418 Query: 427 GLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEY 486 GL+ GVFT D+ +A + L+AGT+W+N Y + + PFGG K SG GRE Y Sbjct: 419 GLAGGVFTADLARAHRVVDGLEAGTLWINTYNLCPVEIPFGGSKQSGFGRENSAAALEHY 478 Query: 487 TEVKTVTVKISQKNS 501 +E+KTV V + ++ Sbjct: 479 SELKTVYVSTGKVDA 493 >4I8Q-A nrPDB Length = 514 Score = 345 bits (885), Expect = 3e-95, Method: Compositional matrix adjust. Identities = 192/488 (39%), Positives = 289/488 (59%), Gaps = 14/488 (2%) Query: 15 DLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIG 74 ++ I +++I EW + V + P+ NPATEE + + EDVD AV+AAR+A Sbjct: 18 NVPIPRRQLYIGGEWREPVKKNRIPIINPATEEIIGDIPAATAEDVDIAVEAARKAIARD 77 Query: 75 SPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGK-LY-SNAYLNDLAGCIKTLRY 132 W + ++R + L +A + + +LAT+ES++ GK LY S A ++D+AGC + Y Sbjct: 78 D-WGSTTGAQRAKYLRAIAAKVLEKKSVLATLESLDSGKTLYESAADMDDVAGCFE---Y 133 Query: 133 CAGWADKIQGRTI-PIDGN---FFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGN 188 AG A+ + R + P++ N + +Y EP+GV G I PWN+PL+M IWK+ PAL+ G Sbjct: 134 YAGLAEALDSRRMTPVNLNSDSYKSYVLREPLGVVGLITPWNYPLLMAIWKVAPALAAGC 193 Query: 189 TVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGST 248 ++KP+E +T L + + +E G P G +NI+ G GP AG ++SH +DK++FTGS Sbjct: 194 AAILKPSELASITCLELGEICREIGLPSGALNILTGLGPEAGGPLASHPHVDKISFTGSG 253 Query: 249 EVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADAD-LDNAVEFAHHGVFYHQGQCCIAAS 307 G I AA + +K V+L LGGKSP +V D D LD A E+ G+F + GQ C A S Sbjct: 254 PTGSKIMTAAAQL-VKPVSLALGGKSPIVVFDDIDNLDIAAEWTLFGIFANTGQVCSATS 312 Query: 308 RIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAK 367 R+ V+E+I F+ R ++ K + +PL GP + QY+K+L I + K EGA Sbjct: 313 RLIVQENIASAFMDRLLKWTKNIKISDPLEEDCKLGPVVSAGQYEKVLKFISNAKSEGAT 372 Query: 368 LECGGGPWGN--KGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTF 425 + CGG + KGY+VQPT+ ++V M I KEE+FGPV + FK+ + I+ AN+T Sbjct: 373 ILCGGERPQHLKKGYYVQPTIITDVNTSMEIWKEEVFGPVLCVKTFKTEEQAIELANDTK 432 Query: 426 YGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHE 485 YGL A V +KD+ + + A Q G +W+NC + P+GG K SG GR+LG++G Sbjct: 433 YGLGAAVMSKDVKRCERFTKAFQTGIIWINCSQPTFNELPWGGKKRSGFGRDLGKWGLEN 492 Query: 486 YTEVKTVT 493 + +K VT Sbjct: 493 FLNIKQVT 500 >4LIH-A nrPDB Length = 504 Score = 334 bits (857), Expect = 5e-92, Method: Compositional matrix adjust. Identities = 199/479 (41%), Positives = 290/479 (60%), Gaps = 8/479 (1%) Query: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 + FI+ D+ G+ F +P L +V + + DV+ AV AAR+AF G W ++ Sbjct: 29 RAFIDGASRDAHGGRTFDCVSPIDGRVLAKVADCGEADVNAAVAAARRAFDAGV-WAGLN 87 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 R +L + A L+ L+ +E+++ GK + D+ G + + A DK+ Sbjct: 88 PRARKAVLLRWAALMREHLDELSLLETLDAGKPIGDTTTVDVPGAAYCVEWFAEAIDKVG 147 Query: 142 GRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLT 201 G P D + EP+GV ++PWNFP++M WK GPAL+ GN+VV+KP+E++PLT Sbjct: 148 GEVAPADHHLVGLVTREPVGVVAAVVPWNFPILMAAWKFGPALAAGNSVVLKPSEKSPLT 207 Query: 202 ALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKS 261 A+ VA L EAG P GV N+VPG G G ++ H D+D +AFTGST VGKLI + A +S Sbjct: 208 AIRVAQLAFEAGIPAGVFNVVPGAG-EPGKLLALHRDVDCIAFTGSTAVGKLIMQYAAQS 266 Query: 262 NLKRVTLELGGKSPCIVLADA-DLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFV 320 NLKR LELGGKSP IVL D DLD A + A +FY+ G+ C A SR+ V I D F+ Sbjct: 267 NLKRAWLELGGKSPNIVLPDCPDLDRAAQTAAGAIFYNMGEMCTAGSRLLVHRDIKDAFI 326 Query: 321 RRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNK-- 378 + V A+ Y+ GNPL P V+ G +D Q +++L IE+G+ EG +L GG + Sbjct: 327 EKLVAAARAYVPGNPLDPSVSMGAIVDGIQLERVLGYIEAGRGEG-RLVTGGARVNAETG 385 Query: 379 GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDID 438 G++V+PTVF V + +IA+EEIFGPV ++ F +D+ ++ AN+T YGL+A V+T ++ Sbjct: 386 GFYVEPTVF-EVKPDAKIAREEIFGPVLSVIVFDDVDEAVRIANDTEYGLAAAVWTSNLT 444 Query: 439 KAITISSALQAGTVWVNCYGV-VSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKI 496 A +S L+AGTVWVNCY PFGG+K SGNGR+ + +YTE+K+ +++ Sbjct: 445 TAHDVSRRLRAGTVWVNCYDEGGDMNFPFGGYKQSGNGRDKSLHALEKYTELKSTLIRL 503 >3JZ4-A nrPDB Length = 481 Score = 312 bits (800), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 178/488 (36%), Positives = 275/488 (56%), Gaps = 12/488 (2%) Query: 13 LTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQ 72 L D + + IN EW D+ +G+ V NPA ++L V + ++ A+ AA +A Sbjct: 2 LNDSNLFRQQALINGEWLDANNGEAIDVTNPANGDKLGSVPKMGADETRAAIDAANRAL- 60 Query: 73 IGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRY 132 WR + A ER +L +L+ + LA + ++ GK + A +++ + + Sbjct: 61 --PAWRALTAKERATILRNWFNLMMEHQDDLARLMTLEQGKPLAEAK-GEISYAASFIEW 117 Query: 133 CAGWADKIQGRTIP---IDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNT 189 A +I G TIP D +PIGV I PWNFP M+ K GPAL+ G T Sbjct: 118 FAEEGKRIYGDTIPGHQADKRLIVI--KQPIGVTAAITPWNFPAAMITRKAGPALAAGCT 175 Query: 190 VVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTE 249 +V+KPA QTP +AL +A L AG P GV N+V G G ++S+ + K++FTGSTE Sbjct: 176 MVLKPASQTPFSALALAELAIRAGVPAGVFNVVTGSAGAVGNELTSNPLVRKLSFTGSTE 235 Query: 250 VGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRI 309 +G+ + E K ++K+V+LELGG +P IV DADLD AVE A F + GQ C+ A+R+ Sbjct: 236 IGRQLMEQCAK-DIKKVSLELGGNAPFIVFDDADLDKAVEGALASKFRNAGQTCVCANRL 294 Query: 310 FVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLE 369 +V++ +YD F + + K +G+ L GVT GP ID++ K+ + I ++GA++ Sbjct: 295 YVQDGVYDRFAEKLQQAMSKLHIGDGLDNGVTIGPLIDEKAVAKVEEHIADALEKGARVV 354 Query: 370 CGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLS 429 CGG G F QPT+ +V +++KEE FGP+ + +FK DVI +AN+T +GL+ Sbjct: 355 CGGKAHERGGNFFQPTILVDVPANAKVSKEETFGPLAPLFRFKDEADVIAQANDTEFGLA 414 Query: 430 AGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQ-CPFGGFKMSGNGRELGEYGFHEYTE 488 A + +D+ + + AL+ G V +N G++S + PFGG K SG GRE +YG +Y E Sbjct: 415 AYFYARDLSRVFRVGEALEYGIVGINT-GIISNEVAPFGGIKASGLGREGSKYGIEDYLE 473 Query: 489 VKTVTVKI 496 +K + + + Sbjct: 474 IKYMCIGL 481 >5KLK-A nrPDB Length = 520 Score = 310 bits (795), Expect = 7e-85, Method: Compositional matrix adjust. Identities = 171/473 (36%), Positives = 260/473 (54%), Gaps = 13/473 (2%) Query: 34 SGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLA 93 S F NP + + V E D + V++AV AA+ A + PW + +R L++K+A Sbjct: 51 SASSFANINPVNGKLISDVFEADAKQVNEAVVAAQNALK--GPWGKLSVQDRAALIHKIA 108 Query: 94 DLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPI---DGN 150 D I+ E + G+ A D+ I R A A + DG+ Sbjct: 109 DGIQARFEEFVAAEVADTGRPVHQARTLDIPRAIANFRTFADLAKTSHTDLFEMSTSDGS 168 Query: 151 -FFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLI 209 YT +P+GV G I PW+ PL++ WK+ PAL+CGNTVV KP+E++P +A +A ++ Sbjct: 169 GALNYTVRKPLGVIGVISPWDLPLLLFTWKVAPALACGNTVVAKPSEESPSSATLLAEVM 228 Query: 210 KEAGFPPGVVNIVPGYGP-TAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTL 268 +AG PPGV N++ G+G +AG ++ H I + FTG ++ G I +A +K V+ Sbjct: 229 HDAGVPPGVFNLIHGFGKDSAGEFLTQHPGISALTFTGESKTGSTIMKAVAD-GVKEVSF 287 Query: 269 ELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAK 328 ELGGK+ +V ADADLD A+E F + GQ C+ + R++V SI+DEFV A+ Sbjct: 288 ELGGKNAAVVFADADLDAAIEGVLRSSFTNSGQVCLCSERVYVHRSIFDEFVSGLKVEAE 347 Query: 329 KYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG-PWGN----KGYFVQ 383 + ++G P GV GP I DK+L EGA + GGG P N +G +VQ Sbjct: 348 RLVVGYPDQDGVNMGPLISHGHRDKVLSYYRLAVDEGATVVTGGGVPKFNDERDQGAYVQ 407 Query: 384 PTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITI 443 PT+++ ++D+ R EEIFGPV I F D+VI R N++ YGL+ ++T ++ +A + Sbjct: 408 PTIWTGLSDKARCVTEEIFGPVCHISPFDDEDEVINRVNDSNYGLACAIWTTNLSRAHRV 467 Query: 444 SSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKI 496 S + G VWVN + + + PFGG K+SG GRE G + Y+++ + +KI Sbjct: 468 SRQIHVGLVWVNTWYLRDLRTPFGGVKLSGLGREGGRFSMDFYSDIANICIKI 520 >4F3X-A nrPDB Length = 498 Score = 306 bits (785), Expect = 1e-83, Method: Compositional matrix adjust. Identities = 173/482 (35%), Positives = 266/482 (55%), Gaps = 18/482 (3%) Query: 21 TKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80 T++ I + + ++ + NP T + + E +D AV AA +AF +G W Sbjct: 26 TQLLIGSRFEAGTEAEEH-ILNPRTGAGIIDLAEASHAQIDAAVDAAERAF-VG--WSQT 81 Query: 81 DASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI 140 +ER L K+AD IE++ A +E++N GK + ++L I R+ AG + Sbjct: 82 TPAERSNALLKIADAIEKEADEFAALEALNCGKPINAVKNDELPAIIDCWRFFAGAVRNL 141 Query: 141 QGRTIPIDGNFF----TYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAE 196 P G + + R +PIG+ G I PWN+PL+M+ WK+ PA+ GNTVV KP+E Sbjct: 142 HA---PAAGEYLPGHTSMIRRDPIGIVGSIAPWNYPLMMMAWKLAPAIGGGNTVVFKPSE 198 Query: 197 QTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKE 256 QTPLTAL +A LI + P GVVN++ G G T G A+ +H + V+ TG GK + Sbjct: 199 QTPLTALKLARLIADI-LPEGVVNVITGRGETVGNALINHPKVGMVSITGDIATGKKVLA 257 Query: 257 AAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY 316 AA K+ +KR LELGGK+P IV DADL+ V +Y+ GQ C AA RI+ E IY Sbjct: 258 AAAKT-VKRTHLELGGKAPVIVYGDADLEAVVNGIRTFGYYNAGQDCTAACRIYAEAGIY 316 Query: 317 DEFVR--RSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIE-SGKKEGAKLECGGG 373 ++ V S +Y L + + GP I + Q D++ +E + ++ ++ GG Sbjct: 317 EKLVADLTSAVSTIRYNLDDDTENEI--GPLISRRQRDRVASFVERAADQKHIEITTGGR 374 Query: 374 PWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVF 433 ++G+F QPTV + T E I + E+FGPV + +F DD + AN++ YGL++ V+ Sbjct: 375 TGSDEGFFFQPTVVAGATQEDEIVRREVFGPVVSVTRFTGKDDAVAWANDSDYGLASSVW 434 Query: 434 TKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVT 493 TKDI KA+ +S LQ G W+N + +++ + P GG K SG G+++ Y +YT V+ + Sbjct: 435 TKDISKAMRAASRLQYGCTWINTHFMLTNEMPHGGIKQSGYGKDMSVYALEDYTAVRHIM 494 Query: 494 VK 495 + Sbjct: 495 IN 496 >3I44-A nrPDB Length = 497 Score = 305 bits (782), Expect = 2e-83, Method: Compositional matrix adjust. Identities = 180/475 (37%), Positives = 267/475 (56%), Gaps = 9/475 (1%) Query: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 K +IN W D + V +P+TEE + G D DKA+ AA++AFQ W+T Sbjct: 27 KFYINGLWDDPSTPHDLYVIDPSTEEACAVISLGSTRDADKAINAAKKAFQT---WKTTS 83 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 ER + K+ ++ E+ +A SM G A A +R + Sbjct: 84 PHERLGFVEKILEIYEKRSSDMAKTISMEMGAPIDMALNAQTATGSSHIRNFIKAYKEFS 143 Query: 142 GRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLT 201 + I+GN ++ IGV G I PWN+P+ + K+ PAL G T+V+KP+E PL+ Sbjct: 144 FQEALIEGNEQAILHYDAIGVVGLITPWNWPMNQVTLKVIPALLAGCTMVLKPSEIAPLS 203 Query: 202 ALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKS 261 A+ A ++ EA P GV N++ G G G+ +S+H D++ ++FTGST GK I + A + Sbjct: 204 AMLFAEILDEAALPSGVFNLINGDGANVGSYLSAHPDLEMISFTGSTRAGKDISKNASNT 263 Query: 262 NLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVR 321 LKRV LELGGK I+ ADAD+D H FY+ GQ C A +R+ VE++IYD+ ++ Sbjct: 264 -LKRVCLELGGKGANIIFADADIDALQRGVRH-CFYNSGQSCNAPTRMLVEQAIYDKAIK 321 Query: 322 RSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG--PWG-NK 378 + + A+K +G G GP + KEQYDKI DLI+SG EGA L GG P G + Sbjct: 322 TAKDIAEKTQVGPGHQTGNHIGPVVSKEQYDKIQDLIQSGIDEGATLVTGGTGLPMGMER 381 Query: 379 GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDID 438 GY+V+PTVF++V MRI +EEIFGPV ++ F + D+ + AN+T YGL+ + ++D Sbjct: 382 GYYVRPTVFADVKPHMRIFREEIFGPVLSLLPFNTEDEAVTLANDTEYGLTNYIQSQDRS 441 Query: 439 KAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVT 493 K I++ +++G V VN + + FGG K SG RE G +G E+ + K ++ Sbjct: 442 KCRRIAAQVRSGMVEVNGHELPGGSY-FGGVKFSGRAREGGLWGIKEFLDTKAIS 495 >3U4J-A nrPDB Length = 528 Score = 304 bits (779), Expect = 5e-83, Method: Compositional matrix adjust. Identities = 192/486 (39%), Positives = 285/486 (58%), Gaps = 7/486 (1%) Query: 16 LKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQV-EEGDKEDVDKAVKAARQAFQIG 74 +K +Y ++ ++ + D+ SG +P E+ E +DV KAV AAR+AF G Sbjct: 19 IKSRY-QMLVDGKSVDAASGSTIDRVSPGHAGEVVGTWPEASADDVRKAVAAARKAFDAG 77 Query: 75 SPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCA 134 PW M +ER RL++K+ADLI + LA +ES+ GK + A ++ C Y A Sbjct: 78 -PWPRMSGAERSRLMFKVADLILARQEELALIESLEVGKPIAQAR-GEIGFCADLWSYAA 135 Query: 135 GWADKIQGRTIP-IDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVK 193 G A ++G+T I + EP+GV G I PWNFP ++ ++ A+ G TVV+K Sbjct: 136 GQARALEGQTHNNIGDDRLGLVLREPVGVVGIITPWNFPFIIASERVPWAIGSGCTVVLK 195 Query: 194 PAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKL 253 P+E T T++ +A L +EAG P GV N+V GYG AG ++ ++D VAFTGS VG Sbjct: 196 PSEFTSGTSIRLAELAREAGIPDGVFNVVTGYGDPAGQVLAEDPNVDMVAFTGSVRVGTK 255 Query: 254 IKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEE 313 + E A ++ +KRV LELGGK P IV ADADLD A + +GV+++ GQCCI+ SR+ V+E Sbjct: 256 LGEIAART-VKRVGLELGGKGPQIVFADADLDAAADGIAYGVYHNAGQCCISGSRLLVQE 314 Query: 314 SIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG 373 I D + R ++ ++K G+PL G I + +K+ + +G GA+L GG Sbjct: 315 GIRDALMERLLDISRKVAFGDPLNERTKIGAMISEAHAEKVHSYVTAGITSGAELLLGGE 374 Query: 374 PWGNK-GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGV 432 G + G + PTVF+ VT +M IA+EEIFGPV + FK+ D+ + AN T +GLSA V Sbjct: 375 RIGREAGLYYAPTVFAGVTPDMSIAREEIFGPVLSTLTFKTADEAVALANATEFGLSASV 434 Query: 433 FTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492 ++ +++ A+ ++AG W+N + + P GG+K SG GRELG YGF EY++ K V Sbjct: 435 WSTNLETALQTIRRIRAGRCWINSVIDGTPELPIGGYKKSGLGRELGRYGFDEYSQFKGV 494 Query: 493 TVKISQ 498 V + + Sbjct: 495 HVTLGR 500 >3TY7-A nrPDB Length = 478 Score = 304 bits (778), Expect = 7e-83, Method: Compositional matrix adjust. Identities = 188/484 (38%), Positives = 266/484 (54%), Gaps = 28/484 (5%) Query: 20 YTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRT 79 YTK +IN EW +S S + V NPATEE + +V +G+K DVDKAV+AA + +R Sbjct: 7 YTKQYINGEWVESNSNETIEVINPATEEVIGKVAKGNKADVDKAVEAADDVYL---EFRH 63 Query: 80 MDASERGRLLYKLADLIE--RDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWA 137 ER LL K+ E +D ++ A + + G L + + Y G Sbjct: 64 TSVKERQALLDKIVKEYENRKDDIVQAITDEL-GAPL----------SLSERVHYQMGLN 112 Query: 138 DKIQGRTIPIDGNFFTYTR------HEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVV 191 + R +D F R E IGV G I PWNFP K+ A + G+ VV Sbjct: 113 HFVAARD-ALDNYEFEERRGDDLVVKEAIGVSGLITPWNFPTNQTSLKLAAAFAAGSPVV 171 Query: 192 VKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVG 251 +KP+E+TP A+ +A + + G P GV N+V G G G +S H + ++FTGS G Sbjct: 172 LKPSEETPFAAVILAEIFDKVGVPKGVFNLVNGDGAGVGNPLSEHPKVRMMSFTGSGPTG 231 Query: 252 KLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFV 311 I E A K + K+V+LELGGKSP IVL D D+ A + V + GQ C A +R+ V Sbjct: 232 SKIMEKAAK-DFKKVSLELGGKSPYIVLDDVDIKEAAKATTGKVVNNTGQVCTAGTRVLV 290 Query: 312 EESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECG 371 I D F+ E+ + +GNP G GP I K+Q+D++ + I G +EGA+L G Sbjct: 291 PNKIKDAFLAELKEQFSQVRVGNPREDGTQVGPIISKKQFDQVQNYINKGIEEGAELFYG 350 Query: 372 --GGPWG-NKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGL 428 G P G KGYF +PT+F NV ++M IA+EEIFGPV ++ + LD+ I+ AN+T YGL Sbjct: 351 GPGKPEGLEKGYFARPTIFINVDNQMTIAQEEIFGPVMSVITYNDLDEAIQIANDTKYGL 410 Query: 429 SAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTE 488 + V KD + ++ +++AGTV +N G PFGG+K SG GRE G+YG E+ E Sbjct: 411 AGYVIGKDKETLHKVARSIEAGTVEINEAG-RKPDLPFGGYKQSGLGREWGDYGIEEFLE 469 Query: 489 VKTV 492 VK++ Sbjct: 470 VKSI 473 >5J77-A nrPDB Length = 508 Score = 302 bits (773), Expect = 3e-82, Method: Compositional matrix adjust. Identities = 172/486 (35%), Positives = 272/486 (55%), Gaps = 15/486 (3%) Query: 21 TKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80 TK++I+ +W +S SGK ++P T + + ++E ++DVD+A+ AA AF W + Sbjct: 3 TKLYIDGQWVNSSSGKTVDKYSPVTGQVIGRMEAATRDDVDRAIDAAEDAFW---AWNDL 59 Query: 81 DASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI 140 + ER +++Y+ +LIE++R L + GK A ++ G I ++Y A WA K+ Sbjct: 60 GSVERSKIIYRAKELIEKNRAELENIIMEENGKPVKEAK-EEVDGVIDQIQYYAEWARKL 118 Query: 141 QGRTIPIDGNFFTYTRHE-PIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP 199 G + + +++ P G+ + PWNFP M+ K+ PAL GNTVV+KP+ TP Sbjct: 119 NGEVVEGTSSHRKIFQYKVPYGIVVALTPWNFPAGMVARKLAPALLTGNTVVLKPSSDTP 178 Query: 200 LTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAG 259 +A + EAG P GV+N + G G G I H ++ + TGST G+ I + A Sbjct: 179 GSAEWIVRKFVEAGVPKGVLNFITGRGSEIGDYIVEHKKVNLITMTGSTATGQRIMQKA- 237 Query: 260 KSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEF 319 +N+ ++ LELGGK+P +V DAD+DNA++ +++ GQ CIAA R++V E IYD F Sbjct: 238 SANMAKLILELGGKAPFMVWKDADMDNALKTLLWAKYWNAGQSCIAAERLYVHEDIYDTF 297 Query: 320 VRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGG------G 373 + R VE ++K LG+P GP I+K +++E K+ GAK+ GG G Sbjct: 298 MSRFVELSRKLALGDP--KNADMGPLINKGALQATSEIVEEAKESGAKILFGGSQPSLSG 355 Query: 374 PWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVF 433 P+ N GYF PT+ N + +I +EEIF PV K S++++ AN+ YGL++ +F Sbjct: 356 PYRN-GYFFLPTIIGNADQKSKIFQEEIFAPVIGARKISSVEEMYDLANDNKYGLASYLF 414 Query: 434 TKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVT 493 TKD + S ++ G ++VN G ++Q GF+M+G E +YG EY ++K + Sbjct: 415 TKDPNIIFEASERIRFGELYVNMPGPEASQGYHTGFRMTGQAGEGSKYGISEYLKLKNIY 474 Query: 494 VKISQK 499 V S K Sbjct: 475 VDYSGK 480 >6MVR-A nrPDB Length = 767 Score = 300 bits (769), Expect = 7e-82, Method: Compositional matrix adjust. Identities = 183/470 (38%), Positives = 267/470 (56%), Gaps = 24/470 (5%) Query: 24 FINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDAS 83 FI W + G F NPAT + L QV + + DVD AVKAAR+A P D + Sbjct: 36 FIGGAW--TAPGDLFATVNPATGQTLAQVSQATQADVDAAVKAARKA----QPAWAKDGA 89 Query: 84 ERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGR 143 R R+LY LA L+++ L A +E+++ GK A D+ + + AG+A ++ G Sbjct: 90 ARARVLYALARLLQKHARLFAVLETLDNGKPIREARDIDVPLAQRHFYHHAGYA-QLMGT 148 Query: 144 TIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTAL 203 +P P+GVCGQ+IPWNFPL+ML WKI PAL+ GNTVV+KPAE TPLTAL Sbjct: 149 EMP---------DRAPLGVCGQVIPWNFPLLMLAWKIAPALAMGNTVVLKPAEWTPLTAL 199 Query: 204 HVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNL 263 A + +AG P GVVNIV G G +++ +DKVAFTGST VG+ I+EA + Sbjct: 200 LFADICGQAGVPAGVVNIVTGDGAVGEMIVTAQ--VDKVAFTGSTAVGRRIREATAGTG- 256 Query: 264 KRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRS 323 K ++LELGGK P +V DAD+D+AVE ++++QGQ C A SR+ V+E I D F + Sbjct: 257 KALSLELGGKGPYVVCDDADIDSAVEGLVDAIWFNQGQVCCAGSRLLVQEGIADVFHAKL 316 Query: 324 VERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQ 383 R +G+PL + G + +Q ++ D++ + +G + G + Sbjct: 317 RARMDSLRIGDPLDKCIDIGAMVHPDQLARVRDMV-AANTDGEVYQTA----VPAGCYYP 371 Query: 384 PTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITI 443 PT+ S + + ++EIFGPV F++ + ++ ANNT YGL+A V++++++ A+ + Sbjct: 372 PTLISGLAPASPLMQQEIFGPVLVSTTFRTPAEAVEIANNTAYGLAASVWSENVNLALDL 431 Query: 444 SSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVT 493 + L AG VW+N ++ A PFGG + SG GRE G G YT T Sbjct: 432 APKLVAGIVWINGTNMMDAAAPFGGVRESGFGREGGWEGLAGYTRPAIAT 481 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 70/253 (27%), Positives = 111/253 (43%), Gaps = 24/253 (9%) Query: 19 QYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWR 78 + K++I + G V+ P + L +++D+ AV+A A S W Sbjct: 501 RTAKLYIGGKQTRPDGGYSRAVYGP-KGKLLGHASLSNRKDLRNAVEAMNAA----SGWS 555 Query: 79 TMDASERGRLLYKLAD-LIERDRLLLATMESMNG--GKLYSNAYLNDLAGCIKTLRYCAG 135 R ++LY + + L R ++ M G GK ++A I L A Sbjct: 556 RTTGHLRAQILYFIGENLSARADEFANRIKDMTGKDGK-------AEVAASIDRLFSAAA 608 Query: 136 WADKIQGRT--IPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVK 193 WADK G+ +P+ G EP+G G + P PL+ L+ + PA++ GN V + Sbjct: 609 WADKYDGQVKGVPLRG--VALAMKEPVGKIGILCPDAAPLLGLVSLMAPAIAMGNRVTLA 666 Query: 194 PAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKV-AFTGSTEVGK 252 +E PL A ++ + P GVVNI+ G ++ H+D+D V +G +V Sbjct: 667 ASEAFPLAATDFYQVLDTSDVPAGVVNILTGAHADLAEPMARHLDLDAVWGLSGHAQV-- 724 Query: 253 LIKEAAGKSNLKR 265 EAA NLKR Sbjct: 725 --IEAASAGNLKR 735 >4YWE-A nrPDB Length = 487 Score = 300 bits (767), Expect = 1e-81, Method: Compositional matrix adjust. Identities = 176/482 (36%), Positives = 265/482 (54%), Gaps = 9/482 (1%) Query: 18 IQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPW 77 ++ K FI EW + PV +P+ + + G D+++AV AAR AF PW Sbjct: 9 MEEAKHFIAGEWTLPAQLETIPVVDPSDGQPFATIARGTAPDIERAVAAARDAFA--GPW 66 Query: 78 RTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWA 137 A+ERGR+L +L+ + LA +E+ + GK A + A + + AG A Sbjct: 67 GAASAAERGRVLMRLSARVTDSIEELAAIEARDTGKPLKQARADAAA-LARYFEFYAGAA 125 Query: 138 DKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQ 197 DK+ G T+P + T EP GV G I+PWN+P+ + +G AL+ GN VVKPAE Sbjct: 126 DKLHGETLPYQAGYTVLTVREPHGVTGHIVPWNYPMQIFGRSVGAALAAGNACVVKPAED 185 Query: 198 TPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEA 257 L+ L VA L EAG P G +NIV GYG AGAA++ H ID ++FTGS GKL+ + Sbjct: 186 ACLSVLRVAELAAEAGLPAGALNIVTGYGHEAGAALARHPGIDHISFTGSPATGKLVTQM 245 Query: 258 AGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYD 317 A ++++ VTLELGGKSP IV ADADLD A+ + + GQ C A SR+ +E ++Y+ Sbjct: 246 AAENHVP-VTLELGGKSPQIVFADADLDAALPVLVSAIVQNGGQTCSAGSRVLIERAVYE 304 Query: 318 EFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGN 377 V R +G P + GP I+ +Q ++ D + + +G + G + Sbjct: 305 PLVERLATAFNGLRVG-PSRADLDCGPLINAKQQQRVWDFLSDAQHDGIPMAAHGQVVAD 363 Query: 378 ---KGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFT 434 G++ P + +V R+A+EE+FGPV M+F D+ + AN T YGL AG++T Sbjct: 364 APESGFYQAPALLRDVPPSHRLAQEEVFGPVLAAMRFVDEDEAVALANGTPYGLVAGIWT 423 Query: 435 KDIDKAITISSALQAGTVWVNCYGVVSA-QCPFGGFKMSGNGRELGEYGFHEYTEVKTVT 493 +D + + ++ L+AG V++N YG + PFGG SG+GRE G + +T +KT+ Sbjct: 424 RDGARQMRLARRLRAGQVFINNYGAGGGVELPFGGVGHSGHGREKGFEALYGFTALKTIA 483 Query: 494 VK 495 ++ Sbjct: 484 IR 485 >4JZ6-A nrPDB Length = 500 Score = 296 bits (758), Expect = 1e-80, Method: Compositional matrix adjust. Identities = 181/481 (37%), Positives = 267/481 (55%), Gaps = 14/481 (2%) Query: 21 TKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80 TK+FINN W DS + F +P + E + + D KA +AA +AF+ W+ + Sbjct: 20 TKLFINNAWIDSSDQQTFERKHPVSSEVMTESANATVTDAIKAAQAAEEAFKT---WKDV 76 Query: 81 DASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI 140 SER RLL K+AD++E + +M G A N A R A A +I Sbjct: 77 GPSERRRLLLKVADVMESKTPKFIEVMAMEVGASALWAGFNVHASA-NVFREAASLATQI 135 Query: 141 QGRTIPID-GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP 199 QG TIP D + T +P+G I+PWN V+ I L CGNTVV K +E +P Sbjct: 136 QGETIPTDKAETLSMTLRQPVGPILSIVPWNGTAVLAARAIAYPLVCGNTVVFKGSEFSP 195 Query: 200 LTALHVASLIKEAGFPPGVVNIV---PGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKE 256 T + ++EAG P GV+N + P P A+ S +I ++ FTGST VG +I + Sbjct: 196 ATHALITQCVQEAGLPAGVLNYLNSSPDRSPEIADALISAKEIRRINFTGSTRVGSIIAQ 255 Query: 257 AAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY 316 A + +LKR LELGGKSP IVL DAD++ AV+ A G F QGQ C++ R+ V+E I Sbjct: 256 KAAQ-HLKRCLLELGGKSPLIVLDDADINAAVKAAVFGSFLFQGQICMSTERLVVDEKIA 314 Query: 317 DEFVRRSVERAKKYILGNP-LTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPW 375 DEFV R VE+ ++ +G+P LT GP + ++I L + +GAK+ CGG Sbjct: 315 DEFVARFVEKTERLSVGDPCLTGDCIIGPMVSPNSGERINGLFKDAIDKGAKVVCGGMA- 373 Query: 376 GNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435 +G + T+ +V +MRI EE FGP+ +++ K + I+ AN++ YGLS+GVF + Sbjct: 374 --QGAVMPATILDHVKSDMRIYDEETFGPITVVIRCKGEAEAIRIANDSVYGLSSGVFGR 431 Query: 436 DIDKAITISSALQAGTVWVNCYGVVS-AQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTV 494 DI++A+ + +++ G V +N V + AQ P+GG K +G GR G E+TE+K +T+ Sbjct: 432 DINRALRVGMSIEYGCVHINGSTVQNEAQAPYGGTKNTGYGRFDGRAVIDEFTELKWLTI 491 Query: 495 K 495 + Sbjct: 492 E 492 >4U3W-A nrPDB Length = 505 Score = 292 bits (747), Expect = 3e-79, Method: Compositional matrix adjust. Identities = 179/489 (36%), Positives = 262/489 (53%), Gaps = 15/489 (3%) Query: 19 QYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWR 78 Q + +IN E+ SG FP +P +L V E D VD AV+AA A + G WR Sbjct: 22 QLLRHYINGEF--VASGTTFPNLSPVDGRKLADVCEADAALVDSAVQAAHAAQKAG--WR 77 Query: 79 TMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWAD 138 ++R L+K+AD IE E + G+ + A D+A I R A Sbjct: 78 DTTPAQRAAWLHKIADGIEARFDEFVAAEVADTGRPVAQARTLDIARGIANFRTFADLVR 137 Query: 139 KIQGR---TIPIDGN-FFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKP 194 G T DG+ Y +P+GV G I PWN PL++ WK+ PAL+ GN VV KP Sbjct: 138 TASGEYFETHAADGSELINYVTRKPLGVIGIISPWNLPLLLFTWKVAPALAMGNCVVAKP 197 Query: 195 AEQTPLTALHVASLIKEAGFPPGVVNIVPGYGP-TAGAAISSHMDIDKVAFTGSTEVGKL 253 +E+TP +A +A ++ + G PPGV N++ G+G AG ++ H DI + FTG + G Sbjct: 198 SEETPSSATLLAEVMHDVGLPPGVFNLIHGHGQNAAGEFLTRHPDISAITFTGESRTGST 257 Query: 254 IKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEE 313 I +A +K V+ ELGGK+ +V ADAD D AV F + GQ C+ + R++VE Sbjct: 258 IMKAVA-DGVKEVSFELGGKNAAVVFADADFDAAVAGVLRSSFTNAGQVCLCSERVYVER 316 Query: 314 SIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG 373 I++ FV E+A+ +G P P T GP I + DK+L +EGA + GGG Sbjct: 317 PIFERFVAALKEQAQALRVGAPEDPATTMGPLISRGHRDKVLSYFRLAVEEGATVVTGGG 376 Query: 374 P--WGNK---GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGL 428 +G+ G FV PT+++ + D R +EEIFGPV I F +V+KR N++ YGL Sbjct: 377 APSFGDARDDGAFVMPTIWTGLPDSARCVREEIFGPVCHIAPFDDEAEVVKRVNDSAYGL 436 Query: 429 SAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTE 488 +A ++T + + ++ ++ G VWVN + V + PFGG K+SG GRE G + Y+E Sbjct: 437 AASIWTTQLARGHRVAKQIETGIVWVNAWFVRDLRTPFGGTKLSGLGREGGRHSLDFYSE 496 Query: 489 VKTVTVKIS 497 + V V+I+ Sbjct: 497 LTNVCVRIA 505 >4V6H-A nrPDB Length = 484 Score = 290 bits (741), Expect = 1e-78, Method: Compositional matrix adjust. Identities = 175/488 (35%), Positives = 260/488 (53%), Gaps = 6/488 (1%) Query: 10 PVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQ 69 P + D + + +I EW + S F VF+PAT E L V K + +A Sbjct: 2 PGSMKDPSLLRHQAYIGGEWQAADSDATFEVFDPATGESLGTVP---KMGAAETARAIEA 58 Query: 70 AFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKT 129 A + WR A ER +L + DL+ + LA + + GK + A ++A Sbjct: 59 AQAAWAGWRMKTAKERAAILRRWFDLVIANSDDLALILTTEQGKPLAEAK-GEIAYAASF 117 Query: 130 LRYCAGWADKIQGRTIPI-DGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGN 188 + + A ++ G T+P D N EPIGVC I PWNFP M+ K+GPAL+ G Sbjct: 118 IEWFAEEGKRVAGDTLPTPDANKRIVVVKEPIGVCAAITPWNFPAAMIARKVGPALAAGC 177 Query: 189 TVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGST 248 +VVKPAE TP +AL +A L + AG P GV+++V G G I+S+ + K++FTGST Sbjct: 178 PIVVKPAESTPFSALAMAFLAERAGVPKGVLSVVIGDPKAIGTEITSNPIVRKLSFTGST 237 Query: 249 EVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASR 308 VG+L+ A +K++TLELGG +P IV DADLD AVE A + + GQ C+ +R Sbjct: 238 AVGRLLM-AQSAPTVKKLTLELGGNAPFIVFDDADLDAAVEGAIASKYRNNGQTCVCTNR 296 Query: 309 IFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKL 368 FV E +YD F + K +G G T GP I++ K+ I +GA L Sbjct: 297 FFVHERVYDAFADKLAAAVSKLKVGRGTESGATLGPLINEAAVKKVESHIADALAKGASL 356 Query: 369 ECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGL 428 GG F +PTV + V +M +AKEE FGP+ + +F S +++++ AN+T +GL Sbjct: 357 MTGGKRHALGHGFFEPTVLTGVKPDMDVAKEETFGPLAPLFRFASEEELVRLANDTEFGL 416 Query: 429 SAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTE 488 +A ++++DI + ++ AL+ G V +N + + PFGG K SG GRE YG +Y Sbjct: 417 AAYLYSRDIGRVWRVAEALEYGMVGINTGLISNEVAPFGGVKQSGLGREGSHYGIDDYVV 476 Query: 489 VKTVTVKI 496 +K + V + Sbjct: 477 IKYLCVAV 484 >1WNB-A nrPDB Length = 495 Score = 289 bits (739), Expect = 2e-78, Method: Compositional matrix adjust. Identities = 173/477 (36%), Positives = 261/477 (54%), Gaps = 10/477 (2%) Query: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 K+ IN E S G+K PV+NPAT + L ++ E E + A R A + W Sbjct: 25 KLLINGEL-VSGEGEKQPVYNPATGDVLLEIAEASAE---QVDAAVRAADAAFAEWGQTT 80 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 R L KLAD+IE + + A +ES N GK +A+ +++ + R+ AG A + Sbjct: 81 PKVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARCLN 140 Query: 142 GRTIP--IDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP 199 G ++G+ + R +P+GV I PWN+PL+M WK+ PAL+ GN VV+KP+E TP Sbjct: 141 GLAAGEYLEGHT-SMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITP 199 Query: 200 LTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAG 259 LTAL +A L K+ FP GVVNI+ G G T G ++ H + V+ TGS G+ I Sbjct: 200 LTALKLAELAKDI-FPAGVVNILFGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTA 258 Query: 260 KSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEF 319 S++KR +ELGGK+P IV DAD++ VE +Y+ GQ C AA RI+ ++ IYD Sbjct: 259 -SSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTL 317 Query: 320 VRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGA-KLECGGGPWGNK 378 V + G P GP +++ +E K G K+ GG Sbjct: 318 VEKLGAAVATLKSGAPDDESTELGPLSSLAHLERVGKAVEEAKATGHIKVITGGEKRKGN 377 Query: 379 GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDID 438 GY+ PT+ + + I ++E+FGPV + F + + V+ AN++ YGL++ V+TKD+ Sbjct: 378 GYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWTKDVG 437 Query: 439 KAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495 +A +S+ LQ G WVN + ++ ++ P GG K+SG G+++ YG +YT V+ V VK Sbjct: 438 RAHRVSARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHVMVK 494 >3EK1-A nrPDB Length = 504 Score = 288 bits (738), Expect = 3e-78, Method: Compositional matrix adjust. Identities = 180/488 (36%), Positives = 271/488 (55%), Gaps = 10/488 (2%) Query: 7 PDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKA 66 P + L D + ++ +N W D+ G V NPA + V + +A+ A Sbjct: 19 PGSMLALKDPSLLKSQCLVNGRWIDAADGTTIKVTNPADGSVIGTVPSLSVATIKEAIDA 78 Query: 67 ARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGC 126 + +A S W A ER +L K DLI + +A + + GK + A ++ Sbjct: 79 SAKAL---SGWAAKTAKERAGILRKWFDLIIANADDIALIMTSEQGKPLAEAR-GEVLYA 134 Query: 127 IKTLRYCAGWADKIQGRTIPI--DGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPAL 184 + + A A ++ G TIP +G T R +P+GV I PWNFP M+ K PAL Sbjct: 135 ASFIEWFAEEAKRVYGDTIPAPQNGQRLTVIR-QPVGVTAAITPWNFPAAMITRKAAPAL 193 Query: 185 SCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAF 244 + G T++V+PA+ TPLTAL + L ++AG P GV+ IV G GA ++S+ + K++F Sbjct: 194 AAGCTMIVRPADLTPLTALALGVLAEKAGIPAGVLQIVTGKAREIGAELTSNDTVRKLSF 253 Query: 245 TGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCI 304 TGSTEVG+L+ A +KR++LELGG +P IV DADLD AV+ A + + GQ C+ Sbjct: 254 TGSTEVGRLLM-AQCAPTIKRISLELGGNAPFIVFDDADLDAAVDGAMVSKYRNAGQTCV 312 Query: 305 AASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKE 364 A+RI+V+ +YD+F + + K+ +GN PGV GP I+++ K+ IE + Sbjct: 313 CANRIYVQRGVYDKFAEKLAAKVKELKVGNGTEPGVVIGPMIEEKAITKVKAHIEDAVSK 372 Query: 365 GAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNT 424 GAKL GG G G F +P + + VT +M +AKEE FGP+ + F + ++VI +AN+T Sbjct: 373 GAKLITGGKELG--GLFFEPGILTGVTSDMLVAKEETFGPLAPLFAFDTEEEVIAQANDT 430 Query: 425 FYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFH 484 +GL+A +T++ +AI +S AL+ G V N + + PFGG K SG GRE +YG Sbjct: 431 IFGLAAYFYTENFSRAIRVSEALEYGMVGHNTGLISNEVAPFGGVKQSGLGREGSKYGIE 490 Query: 485 EYTEVKTV 492 EY E K + Sbjct: 491 EYLETKYI 498 >6C43-A nrPDB Length = 477 Score = 288 bits (736), Expect = 5e-78, Method: Compositional matrix adjust. Identities = 174/483 (36%), Positives = 258/483 (53%), Gaps = 15/483 (3%) Query: 18 IQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPW 77 +QY ++ IN D G++ V+NPAT E + ++ E VD AV+AA AF + W Sbjct: 4 MQY-QLLINGVLVDG-EGERQSVYNPATGEVILEIAEASPAQVDAAVQAADNAF---AEW 58 Query: 78 RTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWA 137 R L KLAD IE++ L A +ES N GK +++ + R+ AG A Sbjct: 59 GQTTPKARAECLLKLADSIEQNALEFARLESQNCGKPLHCVINDEIPAIVDVFRFFAGAA 118 Query: 138 DKIQGRTIPIDGNFF----TYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVK 193 + G G + + R +PIGV I PWN+PL+M WK+ PAL+ GN VV+K Sbjct: 119 RCLSGLAA---GEYLEGHTSMIRRDPIGVVASIAPWNYPLMMAAWKLAPALAAGNCVVIK 175 Query: 194 PAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKL 253 P+E TPLTAL +A L K+ FPPGV+N++ G G T G ++ H + V+ TGS G+ Sbjct: 176 PSEITPLTALKLAVLAKDI-FPPGVLNVLFGRGQTVGDVLTGHEKVRMVSLTGSIATGEH 234 Query: 254 IKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEE 313 I + +KR +ELGGK+P IV DADLD + FY+ GQ C AA RI+ + Sbjct: 235 ILRHTAPA-IKRTHMELGGKAPVIVFDDADLDAVAQGVRTFGFYNAGQDCTAACRIYAQR 293 Query: 314 SIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKK-EGAKLECGG 372 IYD V + +G P GP ++ +E K ++ GG Sbjct: 294 GIYDALVEKLGNAVSSLKMGAPEDESTELGPLSSLAHLKRVTAAVEEAKALSHIRVITGG 353 Query: 373 GPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGV 432 KGY+ PT+ ++ E I + E+FGPV I F D V++ AN++ YGL++ V Sbjct: 354 SQTEGKGYYFAPTLLADAKQEDAIVQREVFGPVVSITVFDDEDQVLRWANDSRYGLASSV 413 Query: 433 FTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492 +T+D+ +A +S+ LQ G W+N + ++ ++ P GG K SG G+++ YG +YT V+ + Sbjct: 414 WTQDVGRAHRLSARLQYGCTWINTHFMLVSEMPHGGQKQSGYGKDMSLYGLEDYTLVRHI 473 Query: 493 TVK 495 VK Sbjct: 474 MVK 476 >3B4W-A nrPDB Length = 495 Score = 286 bits (732), Expect = 1e-77, Method: Compositional matrix adjust. Identities = 182/486 (37%), Positives = 261/486 (53%), Gaps = 6/486 (1%) Query: 13 LTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQ 72 ++D +Y K+FI +W + V PAT E + +V DVD AV AAR AF Sbjct: 1 MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPMAAAADVDAAVAAARAAFD 60 Query: 73 IGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRY 132 G PW + ER ++ ++ + L + + G+ + G + + Y Sbjct: 61 NG-PWPSTPPHERAAVIAAAVKMLAERKDLFTKLLAAETGQPPTIIETMHWMGSMGAMNY 119 Query: 133 CAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVV 192 AG ADK+ + EP+GV G I+ WN PL + + KI PAL G T+V+ Sbjct: 120 FAGAADKVTWTETRTGSYGQSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVL 179 Query: 193 KPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGK 252 KPA +TPLTA +A + E G P GV+++VPG G G A++S+ DID FTGS+ VG+ Sbjct: 180 KPAAETPLTANALAEVFAEVGLPEGVLSVVPG-GIETGQALTSNPDIDMFTFTGSSAVGR 238 Query: 253 LIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVE 312 + A + LK TLELGGKS I+L D DL A+ + GQ C+ +RI Sbjct: 239 EVGRRAAEM-LKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQTRILAP 297 Query: 313 ESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGG 372 S YDE V +G P P GP I ++Q ++ I G +EGA+L CGG Sbjct: 298 RSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTRVEGYIAKGIEEGARLVCGG 357 Query: 373 G-PWG-NKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSA 430 G P G + G+F+QPTVF++V ++M IA+EEIFGPV I+ + + +D I AN++ YGL+ Sbjct: 358 GRPEGLDNGFFIQPTVFADVDNKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAG 417 Query: 431 GVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVK 490 V+T D+ K I IS ++ GT +N Y PFGG+K SG GRE G G +T+ K Sbjct: 418 SVWTTDVPKGIKISQQIRTGTYGINWY-AFDPGSPFGGYKNSGIGRENGPEGVEHFTQQK 476 Query: 491 TVTVKI 496 +V + + Sbjct: 477 SVLLPM 482 >5EUY-A nrPDB Length = 491 Score = 284 bits (726), Expect = 7e-77, Method: Compositional matrix adjust. Identities = 164/491 (33%), Positives = 256/491 (52%), Gaps = 11/491 (2%) Query: 13 LTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQ 72 + DL I +IN E+ + +G +P ++ +V +ED +A+ +A +A + Sbjct: 1 MIDLNIMKVANYINGEFKEPSTGAFQVKTSPVDGSKIAEVPRSGREDAREAIDSAFEALK 60 Query: 73 IGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRY 132 W + A R LYK+ ++ + + + ++ GG Y + ++ + ++ Sbjct: 61 ---AWANIPAIRRAEYLYKMLEVFRQMKEDFMKILTVEGGGTYRKVW-GEVVFTERLIQN 116 Query: 133 CAGWADKIQGRTIPIDG-NFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVV 191 A A QGR + D + + GV G I PWN+PL + + KI L+ GNTVV Sbjct: 117 AAELARHYQGRVLQSDSESTISVVFKRSKGVVGVITPWNYPLSISMKKIAHTLAVGNTVV 176 Query: 192 VKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVG 251 KPA TP+T +A ++ +AG P GV N+V G GP G I +H + V FTG + G Sbjct: 177 YKPASDTPVTGWLIAQMVAKAGLPKGVFNLVIGPGPVVGEEIVTHKRVAHVTFTGESSTG 236 Query: 252 KLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFV 311 + I A LK VTLELGG P I+L D D+D A A +HQGQ C +A RI V Sbjct: 237 REIA-AKAAGTLKTVTLELGGSDPLIILDDVDVDYAARLAVFASLFHQGQICTSAKRIIV 295 Query: 312 EESIYDEFVRRSVERAKKYILGNPLT-PGVTQGPQIDKEQYDKILDLIESGKKEGAKLEC 370 +++ D+F+ R V K + +P V GP I++ Q + + ++ G +L Sbjct: 296 HKAVADKFIERYVHYVKMLRIDDPRKDEKVDLGPLINERQVALMKEFVDDAVSRGGRLLI 355 Query: 371 GGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSA 430 GG WGN F +P +F +V RI +EE+FGPV+ I+ ++ D ++ AN+T YGLS Sbjct: 356 GGRSWGN---FFEPAIFVDVDRNFRIMREEVFGPVRPIVVVENDDQAVEVANDTDYGLSG 412 Query: 431 GVFTKDIDKAITISSALQAGTVWVNCYGVV-SAQCPFGGFKMSGNGRELGEYGFHEYTEV 489 V T ++++A I+ A+++G +N + + PFGG K SG GRE GE+ FHE T Sbjct: 413 AVLTNNVNRAFRIAEAVESGMFHINDVTFLEESHVPFGGIKASGVGREGGEWSFHETTYD 472 Query: 490 KTVTVKISQKN 500 + VTV + + Sbjct: 473 RWVTVTLRTRR 483 >5UR2-A nrPDB Length = 984 Score = 270 bits (690), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 179/483 (37%), Positives = 264/483 (54%), Gaps = 22/483 (4%) Query: 23 IFINNEWHDSVSGKKFPVFNPATEEELC-QVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 I INN+ + SGK F NP+ +++ +++ E ++A++AA+ A++ W+ + Sbjct: 499 IVINNK--ELQSGKIFDRVNPSQSDQIVGKIQMATTEQAEQAMQAAQTAYKT---WKNVP 553 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 +R L+ KLAD++ RDR L + + GK ++ A D+ I RY A ++Q Sbjct: 554 CEQRAALVDKLADIMTRDRFKLIATQVLEVGKPWAEAD-GDIGEAIDFCRYYARHMRELQ 612 Query: 142 G--RTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP 199 R + G Y ++ GV I PWNFPL +L + A GNTVV+KPAEQ+ Sbjct: 613 KPLRVGGLPGELSHYI-YKSRGVTAVIAPWNFPLAILAGMVTAAAVAGNTVVMKPAEQST 671 Query: 200 LTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAA- 258 + A + +I+EAGFP GV+N +PGYG G I +H +AFTGS VG I A Sbjct: 672 VVAWGLMKMIQEAGFPQGVINFLPGYGEEVGEYIVNHKYTTTIAFTGSKAVGLHIMNRAA 731 Query: 259 ----GKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEES 314 G+ ++KR +E+GGK+ I+ DADLD AV+ + F GQ C AASR+ V + Sbjct: 732 VVQPGQQHVKRCIIEMGGKNAVIIDNDADLDEAVDGVIYSAFGFSGQKCSAASRVIVLDE 791 Query: 315 IYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGP 374 +YD FV R VE AK + P GP +DKE YD+IL I +K L G P Sbjct: 792 VYDRFVDRLVETAKSIEIHPAENPKAYMGPVVDKEAYDRILGTIAEAEKNHKLLFKGSVP 851 Query: 375 WGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFT 434 G G+F PT+F +V + ++A+ EIFGPV +++ K+LD + AN+T Y L+ GVF+ Sbjct: 852 GG--GFFAPPTIFGDVPGDAKLAQAEIFGPVVAVIRAKNLDQALDIANSTEYALTGGVFS 909 Query: 435 KDIDKAITISSALQAGTVWVN--CYGVVSAQCPFGGFKMSGNGRELG--EYGFHEYTEVK 490 + + L+ G ++VN G + + PFGGFKMSG G + G +Y +Y E Sbjct: 910 RSPANINRVKEELEVGNLYVNRGITGAMVDRHPFGGFKMSGIGSKTGGPDY-LKQYMEPA 968 Query: 491 TVT 493 VT Sbjct: 969 CVT 971 >2HG2-A nrPDB Length = 479 Score = 270 bits (690), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 158/460 (34%), Positives = 248/460 (53%), Gaps = 11/460 (2%) Query: 40 VFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERD 99 V NPATE + ++ +G ED KA+ AA +A W + A ER L K++ I Sbjct: 26 VVNPATEAVISRIPDGQAEDARKAIDAAERA---QPEWEALPAIERASWLRKISAGIRER 82 Query: 100 RLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDG---NFFTYTR 156 ++ + GGK+ A + ++A + Y A WA + +G I D N + R Sbjct: 83 ASEISALIVEEGGKIQQLAEV-EVAFTADYIDYMAEWARRYEGEIIQSDRPGENILLFKR 141 Query: 157 HEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPP 216 +GV I+PWNFP ++ K+ PAL GNT+V+KP+E TP A+ A ++ E G P Sbjct: 142 --ALGVTTGILPWNFPFFLIARKMAPALLTGNTIVIKPSEFTPNNAIAFAKIVDEIGLPR 199 Query: 217 GVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPC 276 GV N+V G G T G ++ + + V+ TGS G+ I A K N+ +V LELGGK+P Sbjct: 200 GVFNLVLGRGETVGQELAGNPKVAMVSMTGSVSAGEKIMATAAK-NITKVCLELGGKAPA 258 Query: 277 IVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPL 336 IV+ DADL+ AV+ + GQ C A R++V++ IYD+FV R E + GNP Sbjct: 259 IVMDDADLELAVKAIVDSRVINSGQVCNCAERVYVQKGIYDQFVNRLGEAMQAVQFGNPA 318 Query: 337 TPG-VTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMR 395 + GP I+ +++ + +EGA++ GG KGY+ PT+ +V EM Sbjct: 319 ERNDIAMGPLINAAALERVEQKVARAVEEGARVAFGGKAVEGKGYYYPPTLLLDVRQEMS 378 Query: 396 IAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVN 455 I EE FGPV ++ F +L+D I AN++ YGL++ ++T++++ A+ L+ G ++N Sbjct: 379 IMHEETFGPVLPVVAFDTLEDAISMANDSDYGLTSSIYTQNLNVAMKAIKGLKFGETYIN 438 Query: 456 CYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495 + Q G++ SG G G++G HEY + + V ++ Sbjct: 439 RENFEAMQGFHAGWRKSGIGGADGKHGLHEYLQTQVVYLQ 478 >6FK3-A nrPDB Length = 536 Score = 268 bits (686), Expect = 3e-72, Method: Compositional matrix adjust. Identities = 184/481 (38%), Positives = 258/481 (53%), Gaps = 31/481 (6%) Query: 42 NPATEEEL-CQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDR 100 NP+ E++ + E DK+ V KA AR+AF + W A RG++L+ L ++ER++ Sbjct: 39 NPSDREDVVARFPEADKDLVRKAALKAREAF---AEWSRTPAPIRGQVLFNLVKILEREK 95 Query: 101 LLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPI---DGNFFTYTRH 157 L + GK A D+ I T + A ++ G+T+P D FT+ R Sbjct: 96 PTLTRLMVREVGKTPKEA-AGDVQEAIDTALFFASEGRRLYGQTVPSEMRDKELFTFRR- 153 Query: 158 EPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPG 217 P+GV G I NFP+ + WK+ PA+ GNTVV KP+E P + A L +EAG PPG Sbjct: 154 -PLGVVGIITAGNFPIAVPSWKLIPAVLTGNTVVWKPSEDAPTLSFVFAKLFEEAGLPPG 212 Query: 218 VVNIVPGYGP-TAGAAISSHMD---IDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGK 273 V+N+V G G + G + MD K AFTGST+VG+ I E AG+ NL R TLELGGK Sbjct: 213 VLNVVFGGGKGSTGQWMVELMDEGLFQKFAFTGSTQVGRWIGEVAGR-NLIRPTLELGGK 271 Query: 274 SPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILG 333 +P +V+ DADLD AVE A F GQ C +A I V+ IY+EF RR +ER + ++G Sbjct: 272 NPLVVMRDADLDLAVEGAWWSAFATGGQRCTSAGNILVDAPIYEEFKRRFLERVEATLVG 331 Query: 334 NPLT-PGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG------PWGN------KGY 380 NPL P VT GP I++ + + + G+ EGA+L G G P+ G Sbjct: 332 NPLLHPEVTYGPFINERFFARWQEHYRVGEAEGARLLFGRGRITRENPYPRFLGDPEAGL 391 Query: 381 FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKA 440 + PTV+ V R+ EE+FGP ++K +++ I AN+T YGLS+ ++T A Sbjct: 392 YGWPTVW-EVRPGTRLFTEEVFGPTINLVKVDGIEEAIAVANSTPYGLSSAIYTNHRHWA 450 Query: 441 ITISSALQAGTVWVNCYGV-VSAQCPFGGFKMSGN-GRELGEYGFHEYTEVKTVTVKISQ 498 ++AG +N V A PFGG K SGN GRE G + EYT V + S Sbjct: 451 YLFKVGIRAGMTSINNATVGAEAHLPFGGVKASGNGGRESGIWVLEEYTYWHAVNEEYSG 510 Query: 499 K 499 + Sbjct: 511 R 511 >3RJL-A nrPDB Length = 538 Score = 266 bits (680), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 165/479 (34%), Positives = 248/479 (51%), Gaps = 33/479 (6%) Query: 25 INNEWHDS-----VSGKKFPV------FNPATEEELC-QVEEGDKEDVDKAVKAARQAFQ 72 +NNEW + G+++ NPA +EE+ V + ++ +KA++AA +AF+ Sbjct: 29 VNNEWLGQSYPLVIDGERYETENKIVSINPANKEEVVGTVSKATQDHAEKAIQAAAKAFE 88 Query: 73 IGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRY 132 WR D ER +L++ + R + + + GK ++ A D A I + Y Sbjct: 89 T---WRYTDPEERAAVLFRAVAKVRRKKHEFSALLVKEAGKPWNEADA-DTAEAIDFMEY 144 Query: 133 CAGWADKIQGRTIPIDG-----NFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCG 187 A ++ + P++ N + YT P GV I PWNF ++ + G Sbjct: 145 YARQMIEL-AKGKPVNSREGERNQYVYT---PTGVTVVIPPWNFLFAIMAGTTVAPIVTG 200 Query: 188 NTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGS 247 NTVV+KPA P+ A +++E+G P GVVN VPG G G + H + FTGS Sbjct: 201 NTVVLKPASAAPVIAAKFVEVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSIITFTGS 260 Query: 248 TEVGKLIKEAA-----GKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQC 302 EVG I E A G+++LK+V E+GGK +V D D++ A + F GQ Sbjct: 261 REVGTRIFERAAKVQPGQTHLKQVIAEMGGKDTVVVDEDCDIELAAQSIFTSAFGFAGQK 320 Query: 303 CIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGK 362 C A SR V E +YDE ++R +E + +G P + V GP ID+ ++KI+D IE GK Sbjct: 321 CSAGSRAVVHEKVYDEVLKRVIEITESKKVGEPDSADVYMGPVIDQASFNKIMDYIEIGK 380 Query: 363 KEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRAN 422 +EG +L GG +KGYF++PT+F+++ + R+ +EEIFGPV K S D+ ++ AN Sbjct: 381 EEG-RLVSGGKGDDSKGYFIEPTIFADLDPKARLMQEEIFGPVVAFSKVSSFDEALEVAN 439 Query: 423 NTFYGLSAGVFTKDIDKAITISSALQAGTVWV--NCYGVVSAQCPFGGFKMSGNGRELG 479 NT YGL+ V TK+ D G ++ NC G + PFGGFKMSG + G Sbjct: 440 NTEYGLTGAVITKNRDHINRAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAG 498 >3QAN-A nrPDB Length = 538 Score = 263 bits (673), Expect = 1e-70, Method: Compositional matrix adjust. Identities = 164/455 (36%), Positives = 244/455 (53%), Gaps = 20/455 (4%) Query: 37 KFPVFNPATEEELC-QVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADL 95 K +NPA +++L V + +++ +KA+++A +AFQ WR ++ ER +L K A + Sbjct: 52 KIQSWNPARKDQLVGSVSKANQDLAEKAIQSADEAFQT---WRNVNPEERANILVKAAAI 108 Query: 96 IERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI-QGRTI---PIDGNF 151 I R + + GK + A D A I L Y A ++ +G+ I P + N Sbjct: 109 IRRRKHEFSAWLVHEAGKPWKEADA-DTAEAIDFLEYYARQMIELNRGKEILSRPGEQNR 167 Query: 152 FTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKE 211 + YT P+GV I PWNF L +++ + GNTVV+KPA TP+ A ++++ Sbjct: 168 YFYT---PMGVTVTISPWNFALAIMVGTAVAPIVTGNTVVLKPASTTPVVAAKFVEVLED 224 Query: 212 AGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVG-KLIKEAA----GKSNLKRV 266 AG P GV+N VPG G G + H + FTGS +VG +L + AA G+++LKRV Sbjct: 225 AGLPKGVINYVPGSGAEVGDYLVDHPKTSLITFTGSKDVGVRLYERAAVVRPGQNHLKRV 284 Query: 267 TLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVER 326 +E+GGK +V DADLD A E F GQ C A SR + + +YDE + ++V Sbjct: 285 IVEMGGKDTVVVDRDADLDLAAESILVSAFGFSGQKCSAGSRAVIHKDVYDEVLEKTVAL 344 Query: 327 AKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTV 386 AK +G+P GP ID++ ++KI+ IE GKKEG +L GG + G+F+QPT+ Sbjct: 345 AKNLTVGDPTNRDNYMGPVIDEKAFEKIMSYIEIGKKEG-RLMTGGEGDSSTGFFIQPTI 403 Query: 387 FSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSA 446 +++ E I +EEIFGPV K D ++ ANNT YGL+ V T++ Sbjct: 404 IADLDPEAVIMQEEIFGPVVAFSKANDFDHALEIANNTEYGLTGAVITRNRAHIEQAKRE 463 Query: 447 LQAGTVWV--NCYGVVSAQCPFGGFKMSGNGRELG 479 G ++ NC G + PFGGFKMSG + G Sbjct: 464 FHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAG 498 >3RH9-A nrPDB Length = 506 Score = 259 bits (663), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 170/472 (36%), Positives = 254/472 (53%), Gaps = 9/472 (1%) Query: 24 FINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDAS 83 +I W DS G F V+NPAT + +V +EDV AV+A + A ++ +PW Sbjct: 15 YIGGRWKDSAGGATFDVYNPATGSVIAKVPSMPEEDVVAAVEAGQSALRLTNPWPI---E 71 Query: 84 ERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGR 143 R + L + D ++ +R + + M GK + A ++ YCA + Sbjct: 72 TRRKWLEDIRDGLKENREEIGRILCMEHGKPWKEAQ-GEVDYAAGFFDYCAKHISALDSH 130 Query: 144 TIPIDGNFFTYTRH-EPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTA 202 TIP T+T H P+GV G I+PWNFP+ M+ K+ AL+ G V+KPA +TPLT Sbjct: 131 TIPEKPKDCTWTVHYRPVGVTGLIVPWNFPIGMIAKKLSAALAAGCPSVIKPASETPLTM 190 Query: 203 LHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVG-KLIKEAAGKS 261 + S++ + P G+VN+V G G + H D+ ++FTGSTEVG KLI + A Sbjct: 191 IAFFSVMDKLDLPDGMVNLVMGKASVIGKVLCEHKDVPMLSFTGSTEVGRKLIVDTA--E 248 Query: 262 NLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVR 321 +K++ LELGG +P IV DADL+ A + F GQ C+ A+RIFV E + D F + Sbjct: 249 QVKKLALELGGNAPFIVFDDADLEAAADNLIANKFRGGGQTCVCANRIFVHEKVADAFGQ 308 Query: 322 RSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG-NKGY 380 + ER K +G+ + G+ GP I+K+ +DK+ ++ +GA L G P G Sbjct: 309 KLAERVNKMTVGDGMNDGIDIGPLINKQGFDKVKRHLQDALDKGASLVAGKQPAELGDGL 368 Query: 381 FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKA 440 F PTV V EM +EE FGP+ + F++ ++VI N+T +GL++ VFT D ++A Sbjct: 369 FFPPTVVQGVDREMCCYQEETFGPLVPMALFRTEEEVIDAGNDTEFGLASYVFTADAERA 428 Query: 441 ITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492 +++ L+ G V N + + PFGG K SG GRE G G E+ E +TV Sbjct: 429 QRVAAGLRFGHVGWNTGTGPTPEAPFGGMKASGIGREGGLEGLFEFVEAQTV 480 >3R64-A nrPDB Length = 508 Score = 258 bits (660), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 176/492 (35%), Positives = 262/492 (53%), Gaps = 21/492 (4%) Query: 18 IQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPW 77 I TK I +W + S + NP + + + ++ DVD A +AA++A + W Sbjct: 10 IDATKHLIGGQWVEGNSDRISTNINPYDDSVIAESKQASIADVDAAYEAAKKA---QAEW 66 Query: 78 RTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLN-DLAGCIKTLRYCAGW 136 A+ER ++Y+ A+L+E R + G S A L LAG I + A + Sbjct: 67 AATPAAERSAIIYRAAELLEEHREEIVEWLIKESGSTRSKANLEITLAGNIT--KESASF 124 Query: 137 ADKIQGRTIPI-----DGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVV 191 ++ GR P + + + GV G I PWNFPL + I + PAL+ GN VV Sbjct: 125 PGRVHGRISPSNTPGKENRVYRVAK----GVVGVISPWNFPLNLSIRSVAPALAVGNAVV 180 Query: 192 VKPAEQTPLTALHV-ASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEV 250 +KPA TP+T + A + +EAG P GV++ V G G G +H ++FTGST V Sbjct: 181 IKPASDTPVTGGVIPARIFEEAGVPAGVISTVAGAGSEIGDHFVTHAVPKLISFTGSTPV 240 Query: 251 GKLIKE-AAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRI 309 G+ + E A +K V LELGG +P +VLADAD+D A + A G F HQGQ C++ +R+ Sbjct: 241 GRRVGELAINGGPMKTVALELGGNAPFVVLADADIDAAAQAAAVGAFLHQGQICMSINRV 300 Query: 310 FVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLE 369 V+ +++DEF+ + VE K G+P G GP I+ Q + + IE KKEGA ++ Sbjct: 301 IVDAAVHDEFLEKFVEAVKNIPTGDPSAEGTLVGPVINDSQLSGLKEKIELAKKEGATVQ 360 Query: 370 CGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLS 429 G +G V P VFS+VT +M IA+EEIFGP+ ++K + AN + +GLS Sbjct: 361 VEGPI---EGRLVHPHVFSDVTSDMEIAREEIFGPLISVLKADDEAHAAELANASDFGLS 417 Query: 430 AGVFTKDIDKAITISSALQAGTVWVNCYGVVSA-QCPFGGFKMSGNGRELGEYGFHEYTE 488 A V++KDID+A + + +G V +N V FGG K SG GR G++ E+T Sbjct: 418 AAVWSKDIDRAAQFALQIDSGMVHINDLTVNDEPHVMFGGSKNSGLGRFNGDWAIEEFTT 477 Query: 489 VKTVTVKISQKN 500 + + +K S +N Sbjct: 478 DRWIGIKRSAEN 489 >1T90-A nrPDB Length = 486 Score = 255 bits (652), Expect = 3e-68, Method: Compositional matrix adjust. Identities = 169/489 (34%), Positives = 259/489 (52%), Gaps = 21/489 (4%) Query: 17 KIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSP 76 +I+ K +IN EW +S + + V NPAT+E LCQV KED+D A + A +AF+ Sbjct: 2 EIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKEDIDYAAQTAAEAFKT--- 58 Query: 77 WRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGW 136 W + R R+L+ L+ + + LA + ++ GK A L ++ I+ + + AG Sbjct: 59 WSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEA-LGEVGRGIENVEFAAGA 117 Query: 137 ADKIQGRTIP-IDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPA 195 + G ++ I + PIGV G I P+NFP+++ W A++ GNT ++KP+ Sbjct: 118 PSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPCWMFPMAIALGNTFILKPS 177 Query: 196 EQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIK 255 E+TPL + L ++AG P GV N+V G I H +I ++F GS VG+ + Sbjct: 178 ERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNG-ILEHPEIKAISFVGSKPVGEYVY 236 Query: 256 EAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESI 315 + G NLKRV G K+ IVL DA+L++ V F G+ C+A + + VEE I Sbjct: 237 KK-GSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAAFGSAGERCMACAVVTVEEGI 295 Query: 316 YDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGP- 374 DEF+ + E+ +GN L GV GP I ++ + L IE G +EGA+L C G Sbjct: 296 ADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKRTLSYIEKGLEEGARLVCDGREN 355 Query: 375 WGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFT 434 + GYFV PT+F NVT EM I K+EIF PV +++ K+L + I+ AN + + A +FT Sbjct: 356 VSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIRVKNLKEAIEIANKSEFANGACLFT 415 Query: 435 KDIDKAITISSALQAGTVWVNCYGVVS--AQCPFGGFKMS------GNGRELGEYGFHEY 486 + + + AG + +N GV + A PF G+K S NG++ ++ Y Sbjct: 416 SNSNAIRYFRENIDAGMLGINL-GVPAPMAFFPFSGWKSSFFGTLHANGKDSVDF----Y 470 Query: 487 TEVKTVTVK 495 T K VT + Sbjct: 471 TRKKVVTAR 479 >5VBF-A nrPDB Length = 478 Score = 252 bits (643), Expect = 3e-67, Method: Compositional matrix adjust. Identities = 158/473 (33%), Positives = 237/473 (50%), Gaps = 6/473 (1%) Query: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 +++I+ +HD+ + PV +P T L ++ D+D AV+AA +AF WR Sbjct: 8 RLYIDGRFHDADGRRTQPVVDPGTTRVLGELPHATAHDIDAAVQAAHRAFVT---WRHES 64 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 R LL + A L + +M+ GK A + ++ + L + A + Sbjct: 65 PLVRSDLLRRAAALARERAETIGRHITMDQGKPLREA-IAEVVSAAEQLEWHAEEGRRTY 123 Query: 142 GRTIPIDG-NFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200 GR +P + EPIGVC PWNFP + KI AL+ G T+V+K E++P Sbjct: 124 GRVVPARSPDVMQTVLREPIGVCAAFSPWNFPFSQAMHKIAAALASGCTLVLKGPEESPS 183 Query: 201 TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGK 260 + +A L +AG PPG +NIV G + + K++FTGS VGK + A Sbjct: 184 AIVALAQLFHDAGLPPGCLNIVWGVPGDVSKQLIEAPQVRKISFTGSVPVGKQLA-ALAA 242 Query: 261 SNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFV 320 S +KR+T+ELGG +P +V ADAD++ A F + GQ C++ +R FV+ + +D FV Sbjct: 243 SLMKRMTMELGGHAPVLVCADADVERAAAMLAAYKFRNAGQVCVSPTRFFVQRAAFDRFV 302 Query: 321 RRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGY 380 ++ +G L GVT GP + D+I + +GA++ GG G+ Sbjct: 303 CAYLDAVGTIRVGYGLDAGVTMGPLAHARRVDEIDAFVADATAKGAQIATGGMRLPGPGH 362 Query: 381 FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKA 440 + PTV T + R+ +E FGP+ I+ F LDD + AN +GL++ FT A Sbjct: 363 YFAPTVVLGPTRDTRLMNDEPFGPIVGIVPFDDLDDALAEANRLPFGLASYAFTTSARNA 422 Query: 441 ITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVT 493 IS AL+AG V +N +G+ A+ PFGG K SG G E G F Y K VT Sbjct: 423 HRISRALEAGMVNINHFGMGPAEIPFGGVKDSGFGSEGGMEAFDGYLVTKFVT 475 >5X5U-A nrPDB Length = 505 Score = 251 bits (642), Expect = 4e-67, Method: Compositional matrix adjust. Identities = 163/476 (34%), Positives = 244/476 (51%), Gaps = 8/476 (1%) Query: 21 TKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80 T++ I+ EW D+ SGK V NPAT + + +V D+D+A+ AA+ F+ WR + Sbjct: 33 TQLLIDGEWVDAASGKTIDVVNPATGKPIGRVAHAGIADLDRALAAAQSGFEA---WRKV 89 Query: 81 DASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI 140 A ER + K A L+ +A + + GK + A + L+ + + A ++ Sbjct: 90 PAHERAATMRKAAALVRERADAIAQLMTQEQGKPLTEARVEVLSAA-DIIEWFADEGRRV 148 Query: 141 QGRTIPID--GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQT 198 GR +P G T + EP+G PWNFP+ ++ K+ AL+ G + +VK E+T Sbjct: 149 YGRIVPPRNLGAQQTVVK-EPVGPVAAFTPWNFPVNQVVRKLSAALATGCSFLVKAPEET 207 Query: 199 PLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAA 258 P + + +AG P GV+ +V G + + H I KV FTGST VGK + A Sbjct: 208 PASPAALLRAFVDAGVPAGVIGLVYGDPAEISSYLIPHPVIRKVTFTGSTPVGKQLASLA 267 Query: 259 GKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDE 318 G ++KR T+ELGG +P IV DAD+ AV+ A F + GQ CI+ +R V SI DE Sbjct: 268 GL-HMKRATMELGGHAPVIVAEDADVALAVKAAGGAKFRNAGQVCISPTRFLVHNSIRDE 326 Query: 319 FVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNK 378 F R V+ A+ +GN L G T G + + + +I++ +K GA +E GG G++ Sbjct: 327 FTRALVKHAEGLKVGNGLEEGTTLGALANPRRLTAMASVIDNARKVGASIETGGERIGSE 386 Query: 379 GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDID 438 G F PTV +NV + + E FGPV I F L++ I AN +GL+ FT+ Sbjct: 387 GNFFAPTVIANVPLDADVFNNEPFGPVAAIRGFDKLEEAIAEANRLPFGLAGYAFTRSFA 446 Query: 439 KAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTV 494 ++ L+ G +W+N + PFGG K SG G E G Y K+VTV Sbjct: 447 NVHLLTQRLEVGMLWINQPATPWPEMPFGGVKDSGYGSEGGPEALEPYLVTKSVTV 502 >3RHD-A nrPDB Length = 486 Score = 248 bits (633), Expect = 4e-66, Method: Compositional matrix adjust. Identities = 156/477 (32%), Positives = 256/477 (53%), Gaps = 21/477 (4%) Query: 23 IFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDA 82 +FI+ +W ++ + V NP + E + ++ +E+ +A+ A + ++ + + Sbjct: 2 MFIDGKW---INREDMDVINPYSLEVIKKIPALSREEAKEAIDTAEKYKEV---MKNLPI 55 Query: 83 SERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQG 142 ++R +L +A I+ + LA + +++ GK A + ++ I T + A + + + Sbjct: 56 TKRYNILMNIAKQIKEKKEELAKILAIDAGKPIKQARV-EVERSIGTFKLAAFYVKEHRD 114 Query: 143 RTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTA 202 IP D +TR EP+G+ G I P+NFPL + KI PA++ GN +V P+ + PL Sbjct: 115 EVIPSDDRLI-FTRREPVGIVGAITPFNFPLNLSAHKIAPAIATGNVIVHHPSSKAPLVC 173 Query: 203 LHVASLIKEA----GFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAA 258 + +A +I+ A P GV N++ G G G I + ++ ++FTGS++VG+LI + A Sbjct: 174 IELAKIIENALKKYNVPLGVYNLLTGAGEVVGDEIVVNEKVNMISFTGSSKVGELITKKA 233 Query: 259 GKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDE 318 G K++ LELGG +P IVL DADL+ AV G F + GQ CI+ I V+ESI D+ Sbjct: 234 G---FKKIALELGGVNPNIVLKDADLNKAVNALIKGSFIYAGQVCISVGMILVDESIADK 290 Query: 319 FVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNK 378 F+ V +AK +GNPL GP I E + + ++E EG KL GG +K Sbjct: 291 FIEMFVNKAKVLNVGNPLDEKTDVGPLISVEHAEWVEKVVEKAIDEGGKLLLGGK--RDK 348 Query: 379 GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDID 438 F PT+ D + + K E F PV I++ +++I AN+T YGL + +FT DI+ Sbjct: 349 ALF-YPTILEVDRDNI-LCKTETFAPVIPIIRTNE-EEMIDIANSTEYGLHSAIFTNDIN 405 Query: 439 KAITISSALQAGTVWVNCYGVVSA-QCPFGGFKMSGNGRELGEYGFHEYTEVKTVTV 494 K++ + L+ G V +N + PFGG K SG GRE +Y E + +KT+ + Sbjct: 406 KSLKFAENLEFGGVVINDSSLFRQDNMPFGGVKKSGLGREGVKYAMEEMSNIKTIII 462 >2W8P-A nrPDB Length = 487 Score = 244 bits (622), Expect = 7e-65, Method: Compositional matrix adjust. Identities = 169/477 (35%), Positives = 252/477 (52%), Gaps = 12/477 (2%) Query: 21 TKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80 T F+ W + + FPV +PA+ L V + + AV+AA +AF WR + Sbjct: 13 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAF---CRWREV 67 Query: 81 DASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI 140 A ER LL K +L+ +++ LA + + GK A+ L L + + A ++ Sbjct: 68 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF-FLEWFSEEARRV 126 Query: 141 QGRTIPIDG-NFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP 199 G I + +PIGV I PWNFP M+ K+G AL+ G TVVVKPAE TP Sbjct: 127 YGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTP 186 Query: 200 LTALHVASLIKEAGFPPGVVNIVPGYGPTA---GAAISSHMDIDKVAFTGSTEVGKLIKE 256 +AL +A L +AG P GV N++P A G AI + + K++FTGST GK++ Sbjct: 187 FSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 246 Query: 257 AAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY 316 A S +KRV++ELGG +P IV A++D AV A F + GQ + +++ V+ I+ Sbjct: 247 HAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTAVCSNQFLVQRGIH 305 Query: 317 DEFVRRSVERAKKYI-LGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPW 375 D FV+ E KK + +GN G TQGP I+++ +K+ + +GA + GG Sbjct: 306 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH 365 Query: 376 GNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435 F +PT+ NVT +M EE FGP+ ++KF + ++ I AN GL+ +++ Sbjct: 366 QLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 425 Query: 436 DIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492 D + ++ L+ G V VN + S +CPFGG K SG GRE +YG EY E+K V Sbjct: 426 DPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 482 >3K2W-A nrPDB Length = 497 Score = 239 bits (609), Expect = 3e-63, Method: Compositional matrix adjust. Identities = 161/495 (32%), Positives = 255/495 (51%), Gaps = 18/495 (3%) Query: 9 LPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAAR 68 + + + DL + FI ++ S + +P+T + + ++ G K D + A++ A+ Sbjct: 1 MSLTVQDLHFKNKVNFIGGQYVPSNESDTIDILSPSTGKVIGEIPAGCKADAENALEVAQ 60 Query: 69 QAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLN-DLAGCI 127 A + + + A R +L A+ I ++ +LA M GKL S A + D+ Sbjct: 61 AAQKAWA---KLTARTRQNMLRTFANKIRENKHILAPMLVAEQGKLLSVAEMEVDVTATF 117 Query: 128 KTLRYCAGWADKIQGRTIPIDG-NFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSC 186 + Y A I+G +P D + Y P GV I WNFPL + KIGPAL Sbjct: 118 --IDYGCDNALTIEGDILPSDNQDEKIYIHKVPRGVVVGITAWNFPLALAGRKIGPALIT 175 Query: 187 GNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTG 246 GNT+V+KP ++TPL + + KEAG P GV+N++ G G G + + TG Sbjct: 176 GNTMVLKPTQETPLATTELGRIAKEAGLPDGVLNVINGTGSVVGQTLCESPITKMITMTG 235 Query: 247 STEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAA 306 ST GK I + + + + V LELGGK+P +V+ DADLD A E A G F + GQ C Sbjct: 236 STVAGKQIYKTSAEY-MTPVMLELGGKAPMVVMDDADLDKAAEDALWGRFANCGQVCTCV 294 Query: 307 SRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGA 366 R++V S+YDEF+ + + K +G+P+ GP+ ++ + D I ++ K+GA Sbjct: 295 ERLYVHASVYDEFMAKFLPLVKGLKVGDPMDADSQMGPKCNQREIDNIDHIVHEAIKQGA 354 Query: 367 KLECGGGPWGNKGY----FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRAN 422 + GG +G+ + +PTV +V + + EE FGP+ I+K S++ I+ N Sbjct: 355 TVATGGKTATVEGFEGGCWYEPTVLVDVKQDNIVVHEETFGPILPIVKVSSMEQAIEFCN 414 Query: 423 NTFYGLSAGVFTK---DIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELG 479 ++ YGLSA V T+ +I++AI S L+ G V++N Q G+K SG G E G Sbjct: 415 DSIYGLSAYVHTQSFANINQAI---SDLEVGEVYINRGMGEQHQGFHNGWKQSGFGGEDG 471 Query: 480 EYGFHEYTEVKTVTV 494 ++G +Y E KTV + Sbjct: 472 KFGLEQYLEKKTVYI 486 >2QE0-A nrPDB Length = 475 Score = 236 bits (602), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 159/486 (32%), Positives = 243/486 (50%), Gaps = 23/486 (4%) Query: 19 QYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWR 78 QY K ++N EW +S + ++ PA+ EL V E+VD +A++A WR Sbjct: 4 QY-KNYVNGEWK--LSENEIKIYEPASGAELGSVPAMSTEEVDYVYASAKKA---QPAWR 57 Query: 79 TMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWAD 138 + ER L+K+AD++ RD+ + + S K Y +A ++++ + + Y A Sbjct: 58 ALSYIERAAYLHKVADILMRDKEKIGAILSKEVAKGYKSA-VSEVVRTAEIINYAAEEGL 116 Query: 139 KIQGRTIPIDGNF-------FTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVV 191 +++G + G+F R EP+G+ I P+N+P+ + KI PAL GN + Sbjct: 117 RMEGEVLE-GGSFEAASKKKIAVVRREPVGLVLAISPFNYPVNLAGSKIAPALIAGNVIA 175 Query: 192 VKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVG 251 KP Q ++ L +A EAG P GV N + G G G I H ++ + FTGST +G Sbjct: 176 FKPPTQGSISGLLLAEAFAEAGLPAGVFNTITGRGSEIGDYIVEHQAVNFINFTGSTGIG 235 Query: 252 KLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFV 311 + I + AG ++ + L LGGK IVL DADL+ + G F + GQ C A R+ V Sbjct: 236 ERIGKMAG---MRPIMLALGGKDSAIVLEDADLELTAKNIIAGAFGYSGQRCTAVKRVLV 292 Query: 312 EESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECG 371 ES+ DE V + E+ +GNP P ID + D + LI +GA Sbjct: 293 MESVADELVEKIREKVLALTIGNP-EDDADITPLIDTKSADYVEGLINDANDKGATALT- 350 Query: 372 GGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAG 431 +G + P +F VT +MR+A EE FGPV I++ S+++ I+ +N + YGL A Sbjct: 351 --EIKREGNLICPILFDKVTTDMRLAWEEPFGPVLPIIRVTSVEEAIEISNKSEYGLQAS 408 Query: 432 VFTKDIDKAITISSALQAGTVWVNCYGVV-SAQCPFGGFKMSGNGRELGEYGFHEYTEVK 490 +FT D +A I+ L+ GTV +N + PF G K SG G + +Y T VK Sbjct: 409 IFTNDFPRAFGIAEQLEVGTVHINNKTQRGTDNFPFLGAKKSGAGIQGVKYSIEAMTTVK 468 Query: 491 TVTVKI 496 +V I Sbjct: 469 SVVFDI 474 >3PRL-A nrPDB Length = 505 Score = 233 bits (593), Expect = 2e-61, Method: Compositional matrix adjust. Identities = 158/460 (34%), Positives = 234/460 (50%), Gaps = 18/460 (3%) Query: 23 IFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDA 82 I N EW +S +G++ + PA+ L + +E+V+ A++ A+ A +I W+ Sbjct: 14 ILRNGEWVESRTGERISISAPASGVALGSIPALSQEEVNDAIQGAKDAQKI---WKIRPI 70 Query: 83 SERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQG 142 ER LLY ADL+E + ++ + K +A + +++ +R+ A A ++ G Sbjct: 71 HERVDLLYAWADLLEERKEIIGELIMHEVAKPKKSA-IGEVSRTADIIRHTADEALRLNG 129 Query: 143 RTIPID------GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAE 196 T+ D EP+GV I P+N+P+ + KI PAL GNTVV KPA Sbjct: 130 ETLKGDQFKGGSSKKIALVEREPLGVVLAISPFNYPVNLAAAKIAPALVTGNTVVFKPAT 189 Query: 197 QTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKE 256 Q L+ + + + +AG P G++ +V G G G + H ID + FTG T G+ I E Sbjct: 190 QGSLSGIKMVEALADAGAPEGIIQVVTGRGSVIGDHLVEHPGIDMITFTGGTTTGERISE 249 Query: 257 AAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY 316 K+ + V LELGGK P IVL DADL G F + GQ C A R+FV++S+ Sbjct: 250 ---KAKMIPVVLELGGKDPAIVLDDADLKLTASQIVSGAFSYSGQRCTAIKRVFVQDSVA 306 Query: 317 DEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG 376 D+ V E ++ +G+P P ID++ I LI+ + GA L G G Sbjct: 307 DQLVANIKELVEQLTVGSP-EDDADITPVIDEKSAAFIQGLIDDALENGATLLSGNKRQG 365 Query: 377 NKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKD 436 N + PT+ +VT MR+A EE FGPV I++ K ++ I +N + YGL A +FTKD Sbjct: 366 N---LLSPTLLDDVTPAMRVAWEEPFGPVLPIIRVKDANEAISLSNQSDYGLQASIFTKD 422 Query: 437 IDKAITISSALQAGTVWVNCYGVVSA-QCPFGGFKMSGNG 475 D+AI I L+ GTV +N PF G K SG G Sbjct: 423 TDRAINIGKHLEVGTVHINAKTERGPDHFPFLGVKKSGLG 462 >2J5N-A nrPDB Length = 516 Score = 230 bits (586), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 153/430 (35%), Positives = 217/430 (50%), Gaps = 19/430 (4%) Query: 77 WRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGW 136 W+ +R RLL K A L+ R + L GK + A D+A I + Y A Sbjct: 90 WKDWPQEDRSRLLLKAAALMRRRKRELEATLVYEVGKNWVEAS-ADVAEAIDFIEYYARA 148 Query: 137 ADKIQGRTI-----PIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVV 191 A + + + P + N Y P+G I PWNFP+ + I ++ GNTV+ Sbjct: 149 ALRYRYPAVEVVPYPGEDNESFYV---PLGAGVVIAPWNFPVAIFTGMIVGPVAVGNTVI 205 Query: 192 VKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVG 251 KPAE + V + EAGFPPGVVN +PG G GA + H I + FTGS EVG Sbjct: 206 AKPAEDAVVVGAKVFEIFHEAGFPPGVVNFLPGVGEEVGAYLVEHPRIRFINFTGSLEVG 265 Query: 252 KLIKEAAGK-----SNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAA 306 I EAAG+ + KR +E GGK IV AD D A E + QGQ C AA Sbjct: 266 LKIYEAAGRLAPGQTWFKRAYVETGGKDAIIVDETADFDLAAEGVVVSAYGFQGQKCSAA 325 Query: 307 SRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGA 366 SR+ + + Y+ + R ++RA++ +G P GP + EQ K+L IE GK EG Sbjct: 326 SRLILTQGAYEPVLERVLKRAERLSVG-PAEENPDLGPVVSAEQERKVLSYIEIGKNEG- 383 Query: 367 KLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFY 426 +L GG +GYF+ PTVF+ V + RIA+EEIFGPV +++ K + ++ AN+T Y Sbjct: 384 QLVLGGKRLEGEGYFIAPTVFTEVPPKARIAQEEIFGPVLSVIRVKDFAEALEVANDTPY 443 Query: 427 GLSAGVFTKDIDKAITISSALQAGTVWVN--CYGVVSAQCPFGGFKMSGNGRELGEYGFH 484 GL+ GV+++ + G ++ N G + PFGGFK+SG + G + Sbjct: 444 GLTGGVYSRKREHLEWARREFHVGNLYFNRKITGALVGVQPFGGFKLSGTNAKTGALDYL 503 Query: 485 E-YTEVKTVT 493 + E+K V Sbjct: 504 RLFLEMKAVA 513 >4DNG-A nrPDB Length = 485 Score = 229 bits (585), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 153/478 (32%), Positives = 238/478 (49%), Gaps = 12/478 (2%) Query: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 K FIN +W SG+ + NP + + + ++ A A++A + W Sbjct: 8 KSFINGKWTGGESGRTEDILNPYDQSVITTASLATGKQLEDAFDIAQKAQK---EWAKST 64 Query: 82 ASERGRLLYKLADLIE--RDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADK 139 +R +L K + RD +++ G + S L + G Sbjct: 65 TEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKSTIELEQTIAILDEAMTYTGELGG 124 Query: 140 IQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP 199 ++ I+G R P+GV I P+NFP+ + + I PA++ GN+VV KP QT Sbjct: 125 VKEVPSDIEGKTNKIYRL-PLGVISSISPFNFPMNLSMRSIAPAIALGNSVVHKPDIQTA 183 Query: 200 LTA-LHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAA 258 ++ +A + AG P GV+N++ G + ++ ++FTGST VG+ I E A Sbjct: 184 ISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGMLTNPIPRLISFTGSTAVGRHIGEIA 243 Query: 259 GKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDE 318 G++ KR+ LELGG +P VL+DAD+D AV+ A G F HQGQ C+ +RI V + +YDE Sbjct: 244 GRA-FKRMALELGGNNPFAVLSDADVDRAVDAAIFGKFIHQGQICMIINRIIVHQDVYDE 302 Query: 319 FVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNK 378 FV + R K+ G+ P GP I++ Q +K L++IE K +G +L G GN Sbjct: 303 FVEKFTARVKQLPYGDQTDPKTVVGPLINERQIEKALEIIEQAKTDGIELAVEGKRVGN- 361 Query: 379 GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDID 438 + P VF + +IA+ E+F P+ I+K S + I AN+T YGLS+ VFT D++ Sbjct: 362 --VLTPYVFVGADNNSKIAQTELFAPIATIIKAGSDQEAIDMANDTEYGLSSAVFTSDLE 419 Query: 439 KAITISSALQAGTVWVNCYGVV-SAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495 K + + +G VN V S FGG K SG GR + E+T K ++++ Sbjct: 420 KGEKFALQIDSGMTHVNDQSVNDSPNIAFGGNKASGVGRFGNPWVVEEFTVTKWISIQ 477 >5TJR-A nrPDB Length = 531 Score = 221 bits (564), Expect = 4e-58, Method: Compositional matrix adjust. Identities = 151/477 (31%), Positives = 248/477 (51%), Gaps = 15/477 (3%) Query: 34 SGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLA 93 +G+ VFNP+T E + +V D+E + +A+ AA+ AF WR ++R ++L++ Sbjct: 49 TGRTADVFNPSTGEAVRKVPLADRETMQQAIDAAKAAF---PAWRNTPPAKRAQVLFRFK 105 Query: 94 DLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGR-TIPIDGNFF 152 L+E + + + S GK +A +L I+ + Y + ++G + + N Sbjct: 106 QLLEANEERIVKLISEEHGKTIEDA-AGELKRGIENVEYATAAPEILKGEYSRNVGPNID 164 Query: 153 TYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEA 212 ++ +PIGV I P+NFP ++ +W A++CGNT ++KP+E+ P + L +A L EA Sbjct: 165 AWSDFQPIGVVAGITPFNFPAMVPLWMYPLAIACGNTFILKPSERDPSSTLLIAELFHEA 224 Query: 213 GFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGG 272 G P GV+N+V G A I + ++ ++F GST + + I + G KRV G Sbjct: 225 GLPKGVLNVVHGDKGAVDALIEAP-EVKALSFVGSTPIAEYIY-SEGTKRGKRVQALGGA 282 Query: 273 KSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAAS-RIFVEESIYDEFVRRSVERAKKYI 331 K+ +++ DADLDNAV + G+ C+A S + V + I D V++ V + K Sbjct: 283 KNHAVLMPDADLDNAVSALMGAAYGSCGERCMAISVAVCVGDQIADALVQKLVPQIKGLK 342 Query: 332 LGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG----NKGYFVQPTVF 387 +G + G+ GP + DK+ I++G +GA+L G + G+F+ T+F Sbjct: 343 IGAGTSCGLDMGPLVTGAARDKVTGYIDTGVAQGAELVVDGRGYKVAGHENGFFLGGTLF 402 Query: 388 SNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSAL 447 VT EM I KEEIFGPV I++ SL++ ++ N+ YG +FT+D + A + Sbjct: 403 DRVTPEMTIYKEEIFGPVLCIVRVNSLEEAMQLINDHEYGNGTCIFTRDGEAARLFCDEI 462 Query: 448 QAGTVWVNC-YGVVSAQCPFGGFKMS--GNGRELGEYGFHEYTEVKTVTVKISQKNS 501 + G V VN V A FGG+K S G+ G G YT+ K +T + Q+ S Sbjct: 463 EVGMVGVNVPLPVPVAYHSFGGWKRSLFGDLHAYGPDGVRFYTKRKAITQRWPQRKS 519 >1UXV-A nrPDB Length = 501 Score = 220 bits (560), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 158/483 (32%), Positives = 237/483 (49%), Gaps = 28/483 (5%) Query: 24 FINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPW--RTMD 81 ++ EW S G++ V +P + +V +E+V++ + F+ G W R M Sbjct: 22 YLAGEWGGS--GQEIEVKSPIDLATIAKVISPSREEVERTLDVL---FKRGR-WSARDMP 75 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 +ER +L K AD+IER+ + A + MN GK S A + ++ + LR KI Sbjct: 76 GTERLAVLRKAADIIERNLDVFAEVLVMNAGKPKSAA-VGEVKAAVDRLRLAELDLKKIG 134 Query: 142 GRTIPIDGNFFTY-----TRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAE 196 G IP D + T R EP+GV I P+N+PL + KI + GN VVVKP+ Sbjct: 135 GDYIPGDWTYDTLETEGLVRREPLGVVAAITPFNYPLFDAVNKITYSFIYGNAVVVKPSI 194 Query: 197 QTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKE 256 PL A + +AGFPP + ++ G A ++ + V+FTGSTEVG+ + + Sbjct: 195 SDPLPAAMAVKALLDAGFPPDAIALLNLPGKEAEKIVADDR-VAAVSFTGSTEVGERVVK 253 Query: 257 AAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY 316 G +K+ +ELGG P IVL DADLD A + G++ + GQ C A + E +Y Sbjct: 254 VGG---VKQYVMELGGGDPAIVLEDADLDLAADKIARGIYSYAGQRCDAIKLVLAERPVY 310 Query: 317 DEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG 376 + V +R +G+P P V GP I D+++ IE ++G ++ GG G Sbjct: 311 GKLVEEVAKRLSSLRVGDPRDPTVDVGPLISPSAVDEMMAAIEDAVEKGGRVLAGGRRLG 370 Query: 377 NKGYFVQPTVFSNVTD---EMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVF 433 +VQPT+ D +M + K E+F PV ++ K LD I+ AN YGL A VF Sbjct: 371 PT--YVQPTLVEAPADRVKDMVLYKREVFAPVALAVEVKDLDQAIELANGRPYGLDAAVF 428 Query: 434 TKDIDKAITISSALQAGTVWVN---CYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVK 490 +D+ K L+ G +++N +G+ PFGG K SG RE Y T K Sbjct: 429 GRDVVKIRRAVRLLEVGAIYINDMPRHGI--GYYPFGGRKKSGVFREGIGYAVEAVTAYK 486 Query: 491 TVT 493 T+ Sbjct: 487 TIV 489 >3VZ0-A nrPDB Length = 459 Score = 215 bits (548), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 142/419 (33%), Positives = 204/419 (48%), Gaps = 5/419 (1%) Query: 77 WRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGW 136 W+ ++R ++ + ADL+ RDR A++ + GK +A L ++ L + A Sbjct: 44 WKLRSIAQRKEIVSRAADLLRRDRQHHASLIATEMGKALPDA-LEEIDVTADILSFYANG 102 Query: 137 ADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAE 196 A++ T ++P+G+ I PWNFP L GP L GN V+ K A Sbjct: 103 AEEFLAPTPLKVKTGQAKIINQPLGIIYCIEPWNFPYYQLARVAGPNLMAGNVVIAKHAP 162 Query: 197 QTPLTALHVASLIKEAGFPPGV-VNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIK 255 P AL L +AG P G NI A + I VA TGS E Sbjct: 163 NVPQCALAFEKLFHDAGAPVGAYANIF--LDNDQSAELIKDERIRGVALTGS-ERAGQAV 219 Query: 256 EAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESI 315 A + LK+ T+ELGG IVL DADLD AV++A G F + GQ C AA R+ V E + Sbjct: 220 AAQAGAALKKDTMELGGSDAFIVLDDADLDLAVKWAVWGRFANNGQVCTAAKRMIVHEKV 279 Query: 316 YDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPW 375 YD F+ ++ +GNPL T GP + LD K GA L GG Sbjct: 280 YDAFLDGLKTAITRFRIGNPLDRDTTHGPMSSLRAMELALDQTAEAVKGGATLVAGGKRM 339 Query: 376 GNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435 KG+F++PT+ ++V+ + + +EIFGPV + K S I AN++ YGL VF++ Sbjct: 340 DRKGFFMEPTILTDVSKDNPVFYQEIFGPVAVVHKVASEQAAIDLANDSPYGLGGAVFSR 399 Query: 436 DIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTV 494 DI +A ++ ++ G V++N + + PFGG K SG GREL G E+ K V + Sbjct: 400 DIARAEKVAEQVETGMVFINTATAAAPELPFGGIKNSGFGRELSFLGIEEFINRKLVRI 458 >4ZZ7-A nrPDB Length = 501 Score = 213 bits (541), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 146/466 (31%), Positives = 242/466 (51%), Gaps = 17/466 (3%) Query: 40 VFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERD 99 VFNPAT E Q++ + V++A+ AA+ AF WR +R R++++ +L+E+ Sbjct: 25 VFNPATGEIGKQLDLASTKTVEQAISAAQHAFPT---WRNTPPLKRARVMFRFKELLEQH 81 Query: 100 RLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQG-RTIPIDGNFFTYTRHE 158 + + GK+ +A + +L I+ + Y G + ++G + + +++ + Sbjct: 82 ADEICRLIGEEHGKIAHDA-MGELQRGIENVEYACGAPELLKGEHSRNVGPGIDSWSEFQ 140 Query: 159 PIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGV 218 P+GV I P+NFP+++ +W A+ CGN V+KP+E+ P + L++A L++EAG P GV Sbjct: 141 PMGVVAGITPFNFPVMVPLWMFPMAIVCGNCFVLKPSERDPSSTLYIAQLLQEAGLPDGV 200 Query: 219 VNIVPGYGPTAGAAISSHMD-IDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCI 277 +N+V G A + H D + V+F GST + + I A +N KR G K+ I Sbjct: 201 MNVVNGDKEAVDALL--HDDRVKAVSFVGSTPIAEYIYRTA-SANGKRCQALGGAKNHAI 257 Query: 278 VLADADLDNAVEFAHHGVFYHQGQCCIAAS-RIFVEESIYDEFVRRSVERAKKYILGNPL 336 V+ DAD+DNAV F G+ C+A S + V ++ D V + + +K +G Sbjct: 258 VMPDADMDNAVNQLLGAAFGSSGERCMALSVAVAVGDAAGDALVSKMTQAMQKLKVGPST 317 Query: 337 TPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG----PWGNKGYFVQPTVFSNVTD 392 G GP I ++ +K++ I S +++GA + G P G+FV T+ +VT Sbjct: 318 DSGNDFGPVITRQHQEKVIGYINSAEQQGATIVVDGRQPKVPNHENGFFVGGTLIDHVTP 377 Query: 393 EMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTV 452 EM +EEIFGPV Q+++ ++ D + + YG +FT+D + A S +Q G V Sbjct: 378 EMTSYQEEIFGPVLQVVRVATMQDAMDLIDAHEYGNGTCIFTRDGEAARYFSDNIQVGMV 437 Query: 453 WVNC-YGVVSAQCPFGGFKMS--GNGRELGEYGFHEYTEVKTVTVK 495 +N V A FGG+K S G+ G YT+ KTVT + Sbjct: 438 GINIPLPVPVAYHSFGGWKRSLFGDLHAYGPDAVRFYTKRKTVTQR 483 >5N5S-A nrPDB Length = 515 Score = 209 bits (533), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 144/421 (34%), Positives = 211/421 (50%), Gaps = 18/421 (4%) Query: 84 ERGRLLYKL-ADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQG 142 ER +L K+ A+L R + T+ +M GK +A ++ I T + A + +I G Sbjct: 99 ERKAVLEKVVAELKNRFEEIAQTL-TMESGKPIKDAR-GEVTRTIDTFQVAAEESVRIYG 156 Query: 143 RTIPID-----GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQ 197 IP+D + PIG + PWNFPL ++ K+ PA++ G V+KPA + Sbjct: 157 EHIPLDISARNKGLQGIVKKFPIGPVSMVSPWNFPLNLVAHKVAPAIAVGCPFVLKPASR 216 Query: 198 TPLTALHVASLI-KEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKE 256 TPL+AL + ++ K P G +I+P A + + FTGS +G +K Sbjct: 217 TPLSALILGEILHKIEELPLGAFSILPVSREDADM-FTVDERFKLLTFTGSGPIGWDMKA 275 Query: 257 AAGKSNLKRVTLELGGKSPCIVLADA-DLDNAVEFAHHGVFYHQGQCCIAASRIFVEESI 315 AGK K+V +ELGG +PCIV DLD ++ +G FY GQ CI R++V E + Sbjct: 276 RAGK---KKVVMELGGNAPCIVDDYVPDLDYTIQRLINGGFYQGGQSCIHMQRLYVHERL 332 Query: 316 YDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPW 375 YDE V KK +GNP GP I + I D ++ +G KL GG Sbjct: 333 YDEVKEGFVAAVKKLKMGNPFEEDTYLGPMISESAAKGIEDWVKEAVAKGGKLLTGGN-- 390 Query: 376 GNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435 KG F++PTV +V E KEEIFGPV + K+ + +K NNT YGL +G+FTK Sbjct: 391 -RKGAFIEPTVIEDVPIEANARKEEIFGPVVLLYKYSDFKEAVKECNNTHYGLQSGIFTK 449 Query: 436 DIDKAITISSALQAGTVWVNCYGVVSAQC-PFGGFKMSGNGRELGEYGFHEYTEVKTVTV 494 D++KA ++ G V +N + P+GG K SG RE +Y + E K + + Sbjct: 450 DLNKAFYAFEHMEVGGVILNDSPALRVDSQPYGGLKDSGIQREGVKYAMDDMLETKVLVM 509 Query: 495 K 495 + Sbjct: 510 R 510 >3ROS-A nrPDB Length = 484 Score = 209 bits (532), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 137/465 (29%), Positives = 223/465 (47%), Gaps = 9/465 (1%) Query: 37 KFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLI 96 K+ NP T E + + +D+A+ A ++ WR + + R +L+ +A+ + Sbjct: 5 KYQSVNPYTNEAFASYDNPTSKQIDEAINLAHALYK---KWRHEEPASRAEILHDIANAL 61 Query: 97 ERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTR 156 + LA M ++ GKL S + ++ C+ Y A ++ T Y Sbjct: 62 KEHEDELAKMMTLEMGKLLSESK-EEVELCVSICNYYADHGPEMLKPTKLNSDLGNAYYL 120 Query: 157 HEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPP 216 + GV PWNFPL +I P GN +++K A P +A A +IK AG P Sbjct: 121 KQSTGVIMACEPWNFPLYQVIRVFAPNFIVGNPILLKHAHNVPGSAALTAKIIKRAGAPE 180 Query: 217 G-VVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSP 275 G ++N+ P Y A I + I VA TGS G + EAAGK NLK+ T+ELGG Sbjct: 181 GSLINLYPSYDQLAD--IIADPRIQGVALTGSERGGSAVAEAAGK-NLKKSTMELGGNDA 237 Query: 276 CIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNP 335 IVL DAD + Y+ GQ C ++ RI VE+S YDE + G+P Sbjct: 238 FIVLDDADPQVLRNVLNDARTYNDGQVCTSSKRIIVEKSRYDEVLHELKNVFSNLKAGDP 297 Query: 336 LTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMR 395 L T P ++ +K+ ++ GAK+ +KG F +PT+ +++ + Sbjct: 298 LEADTTLPPMNSEKAKEKLEAQVKEAIDAGAKVFYQYPEIDSKGAFFRPTILTDIAKDNP 357 Query: 396 IAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVN 455 + +E+FGP+ ++ + + I+ AN++ YGL + V DID+A +S+ ++ G +N Sbjct: 358 VFDKEVFGPIAEVFVVEDDNAAIQLANDSSYGLGSSVIGSDIDRAKKVSAQIETGMTVIN 417 Query: 456 CYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKN 500 + S + PFGG K SG GREL G + + + + +++ N Sbjct: 418 GRWITSGELPFGGIKKSGYGRELSGLGLMAFVN-EHLVIDVTKNN 461 >3VZ3-A nrPDB Length = 457 Score = 209 bits (531), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 138/454 (30%), Positives = 208/454 (45%), Gaps = 6/454 (1%) Query: 42 NPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRL 101 NP T E + + ++D + A++AFQ +R S+R + L A ++ERD Sbjct: 10 NPTTGEICQRFKALTPAEIDAKLAKAQEAFQA---YRRTSFSQRRQWLENAAAILERDTS 66 Query: 102 LLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIG 161 A + + GK + +A + + RY A ++ +Y ++P+G Sbjct: 67 KFAEIMTTEMGKTHQSA-IAEAEKSALVCRYYAEHGEQFLANEYTETQATESYVCYQPLG 125 Query: 162 VCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNI 221 + ++PWNFP + PAL GN V+K A P AL V ++++ AGFP GV Sbjct: 126 ILLAVMPWNFPFWQVFRFAAPALMAGNVAVLKHASNVPQCALAVEAILEAAGFPEGVFQT 185 Query: 222 VPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLAD 281 + G + + + TGS G + AG+ +K LELGG P +V Sbjct: 186 LL-IGASQVEQVIKDPRVKAATLTGSEPAGASLASLAGQ-EIKPTLLELGGSDPFVVFPS 243 Query: 282 ADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVT 341 ADLD AVE + GQ IAA R + E+I EF+ + + +G+P+ P Sbjct: 244 ADLDEAVEVGTVARTMNNGQSAIAAKRFILHEAIAAEFLEKLHLKFASLKIGDPMAPETD 303 Query: 342 QGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEI 401 GP + I ++ GAK+ GG P GYF PT+ + + +I +EE+ Sbjct: 304 IGPLATEGILQDISRQVDQAVAAGAKILLGGRPLDRAGYFYPPTILTEIPPGAKILQEEL 363 Query: 402 FGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVS 461 F PV + K LD I AN+ +GL A +T D + L AG V++N Sbjct: 364 FAPVAMVFTVKDLDQAIALANDIPFGLGASAWTNDPAEQQRFIQELDAGAVFINGMVKSD 423 Query: 462 AQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495 + PFGG K SG GRELG G + KTV +K Sbjct: 424 PRLPFGGTKRSGYGRELGLAGIRTFVNAKTVWLK 457 >2JG7-A nrPDB Length = 510 Score = 207 bits (528), Expect = 6e-54, Method: Compositional matrix adjust. Identities = 138/487 (28%), Positives = 231/487 (47%), Gaps = 28/487 (5%) Query: 26 NNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASER 85 N W S G+ + PA E + +V + + ++ V+ R+A+++ W + A +R Sbjct: 27 NGSWGGS--GEVITSYCPANNEPIARVTQATLAEYEETVQKTREAWKM---WADIPAPKR 81 Query: 86 GRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTI 145 G ++ ++ D + + +L ++ S+ GK+Y + ++ + Y G + I G + Sbjct: 82 GEIVRQIGDALRKKIKVLGSLVSLEMGKIYVEG-VGEVQEYVDVCDYAVGLSRMIGGPVL 140 Query: 146 PIDGNFFTYTRH-EPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALH 204 P + P+G+ G I +NFP+ + W AL+CGN + K A TPLT++ Sbjct: 141 PSERPGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIALTCGNVCLWKGAPTTPLTSVA 200 Query: 205 VASLIKEA----GFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGK 260 V ++ E P + ++ G G G A++ +D ++FTGST VGK++ + Sbjct: 201 VTKIVAEVLEQNNLPGAICSMTCG-GADIGTAMAKDERVDLLSFTGSTHVGKMVAMMV-Q 258 Query: 261 SNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFV 320 R LELGG + IV DADL+ V A GQ C R+ + ES++D V Sbjct: 259 ERFGRKLLELGGNNAIIVFEDADLNLVVPSAVFASVGTAGQRCTTTRRLMLHESVHDAVV 318 Query: 321 RRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGY 380 R + K+ +G+P P GP K+ D+ L IE K++G L CGG G Sbjct: 319 ERIAKAYKQVRIGDPWDPSTLYGPLHTKQAVDQYLAAIEQAKQQGGTLVCGGKVMDRPGN 378 Query: 381 FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKA 440 +V+PT+ + + + I E F P+ ++KFK+ ++ N GLS+ +FTKD+ + Sbjct: 379 YVEPTIITGLAHDAPIVHTETFVPILYVLKFKTEEEAFAWNNEVQQGLSSSIFTKDLGRV 438 Query: 441 ITISSALQAGTVWVNCYGVVSAQCP---------FGGFKMSGNGRELGEYGFHEYTEVKT 491 G +C G+V+ P FGG K +G GRE G + +Y T Sbjct: 439 FR-----WLGPKGSDC-GIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDSWKQYMRRST 492 Query: 492 VTVKISQ 498 T+ S+ Sbjct: 493 CTINYSK 499 >3EFV-A nrPDB Length = 462 Score = 205 bits (521), Expect = 5e-53, Method: Compositional matrix adjust. Identities = 145/454 (31%), Positives = 216/454 (47%), Gaps = 12/454 (2%) Query: 42 NPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRL 101 NPAT + L + + ++++ A+ A F+ W+ ++R + L + + Sbjct: 13 NPATGQTLAAMPWANAQEIEHALSLAASGFK---KWKMTSVAQRAQTLRDIGQALRAHAE 69 Query: 102 LLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIP---IDGNFFTYTRHE 158 +A + GK A A K+ C +A+ P + N + Sbjct: 70 EMAQCITREMGKPIKQAR----AEVTKSAALCDWYAEHGPAMLNPEPTLVENQQAVIEYR 125 Query: 159 PIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGV 218 P+GV I+PWNFPL ++ P L GN+ ++K A A +A ++ EAG P GV Sbjct: 126 PLGVILAIMPWNFPLWQVLRGAVPILLAGNSYLLKHAPNVTGCAQMIARILAEAGTPAGV 185 Query: 219 VNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIV 278 V I+ I V TGS G I A + LK+ LELGG P IV Sbjct: 186 YGWVNANNEGVSQMINDP-RIAAVTVTGSVRAGAAIGAQA-GAALKKCVLELGGSDPFIV 243 Query: 279 LADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTP 338 L DADL+ AV+ A G + + GQ C AA R VEE I F R V A +G+PL Sbjct: 244 LNDADLELAVKAAVAGRYQNTGQVCAAAKRFIVEEGIAQAFTDRFVAAAAALKMGDPLVE 303 Query: 339 GVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAK 398 GP + D++ +++ EGA+L GG +G + TV ++VT +M + Sbjct: 304 ENDLGPMARFDLRDELHQQVQASVAEGARLLLGGEKIAGEGNYYAATVLADVTPDMTAFR 363 Query: 399 EEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYG 458 +E+FGPV I K + AN++ +GLSA +FT D A +++ L+ G V++N Y Sbjct: 364 QELFGPVAAITVAKDAAHALALANDSEFGLSATIFTADDTLAAEMAARLECGGVFINGYS 423 Query: 459 VVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492 A+ FGG K SG GREL +G HE+ V+TV Sbjct: 424 ASDARVAFGGVKKSGFGRELSHFGLHEFCNVQTV 457 >5KF0-A nrPDB Length = 485 Score = 203 bits (516), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 130/388 (33%), Positives = 193/388 (49%), Gaps = 19/388 (4%) Query: 120 LNDLAG----CIKTLRYCAGWADKIQGRTIPID-----GNFFTYTRHEPIGVCGQIIPWN 170 +ND G I T R + A +I G + ++ + YTR PIG C I P+N Sbjct: 103 INDSRGEVTRLIDTFRVASEEAVRIDGEVLNLEISARAQGYTGYTRRVPIGPCSFISPFN 162 Query: 171 FPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAG 230 FPL + K+ PAL+ G V+KPA +TP+ AL +A ++ E P G +++P + A Sbjct: 163 FPLNLAAHKVAPALAAGCPFVLKPASRTPVGALIIAEVLAETNLPKGAFSVLPAHRDGAD 222 Query: 231 AAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADA--DLDNAV 288 ++ ++FTGS VG +KE AGK K+V LELGG + IV AD LD V Sbjct: 223 -LFTTDERFRLLSFTGSPAVGWALKEKAGK---KKVVLELGGNAAAIVDADQFEQLDYVV 278 Query: 289 EFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDK 348 + G +Y GQ CI RI V S+YD + V + + +G+P P GP I + Sbjct: 279 DRLAFGAYYQSGQSCIGVQRILVHASLYDTLRDKLVAKTRSLKMGDPKDPSTFVGPMISE 338 Query: 349 EQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQI 408 + ++ +++ GAK+ GG G + T+ +V E + ++E FGPV + Sbjct: 339 SESRRLSGWMDAAVAAGAKIIAGG---KVDGAMFEATLLEDVGREQDLYRKEAFGPVAIL 395 Query: 409 MKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSA-QCPFG 467 KF DD + R N++ +GL AGVFT + A L+ G V +N P+G Sbjct: 396 EKFDRFDDALARVNDSDFGLQAGVFTDSLTHAQRAWDELEVGGVVINDVPSFRVDNMPYG 455 Query: 468 GFKMSGNGRELGEYGFHEYTEVKTVTVK 495 G K SG GRE Y + TE + + V+ Sbjct: 456 GVKDSGLGREGIRYAIEDMTEPRLMVVR 483 >4OGD-A nrPDB Length = 465 Score = 202 bits (515), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 135/436 (30%), Positives = 209/436 (47%), Gaps = 6/436 (1%) Query: 68 RQAFQIGSPWRTMDA-SERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGC 126 +A + WR D ER L+++A+++ RDR A + + + GKL++ A ++ C Sbjct: 30 ERAHLLYKKWRKEDHLEERKAQLHQVANILRRDRDKYAEIMTKDMGKLFTEAQ-GEVDLC 88 Query: 127 IKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSC 186 Y A AD+ T + Y + GV + PWNFP ++ P Sbjct: 89 ADIADYYADKADEFLMSTPLETDSGQAYYLKQSTGVILAVEPWNFPYYQIMRVFAPNFIV 148 Query: 187 GNTVVVKPAEQTPLTALHVASLIKEAGFPPG-VVNIVPGYGPTAGAAISSHMDIDKVAFT 245 GN +V+K A P +A L+ EAG G + N+ Y + + + + V T Sbjct: 149 GNPMVLKHASICPRSAQSFEELVLEAGAEAGSITNLFISYDQVS--QVIADKRVVGVCLT 206 Query: 246 GSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIA 305 GS G I E AGK NLK+ TLELGG I+L DAD D + + Y+ GQ C + Sbjct: 207 GSERGGASIAEEAGK-NLKKTTLELGGDDAFIILDDADWDQLEKVLYFSRLYNAGQVCTS 265 Query: 306 ASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEG 365 + R V + YD F + K G+P+ P T P + +LD I+ G Sbjct: 266 SKRFIVLDKDYDRFKELLTKVFKTAKWGDPMDPETTLAPLSSAQAKADVLDQIKLALDHG 325 Query: 366 AKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTF 425 A+L GG + G+FV PT+ + +T + I +EIFGPV +I K S ++ I+ AN++ Sbjct: 326 AELVYGGEAIDHPGHFVMPTIIAGLTKDNPIYYQEIFGPVGEIYKVSSEEEAIEVANDSN 385 Query: 426 YGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHE 485 YGL +F+ + + A +++ ++ G ++N + PFGG K SG GREL E GF Sbjct: 386 YGLGGTIFSSNQEHAKAVAAKIETGMSFINSGWTSLPELPFGGIKHSGYGRELSELGFTS 445 Query: 486 YTEVKTVTVKISQKNS 501 + + + NS Sbjct: 446 FVNEHLIYIPNKTNNS 461 >4X0T-A nrPDB Length = 513 Score = 201 bits (511), Expect = 6e-52, Method: Compositional matrix adjust. Identities = 141/481 (29%), Positives = 227/481 (47%), Gaps = 32/481 (6%) Query: 35 GKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLAD 94 G+ + PA E + +V + D ++ VK AR+A++I W + A +RG ++ ++ D Sbjct: 37 GEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKI---WADIPAPKRGEIVRQIGD 93 Query: 95 LIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTY 154 + +L ++ S+ GK+ + ++ + Y G + I G +P + + Sbjct: 94 ALREKIQVLGSLVSLEMGKILVEG-VGEVQEYVDICDYAVGLSRMIGGPILPSERSGHAL 152 Query: 155 TRH-EPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIK--- 210 P+G+ G I +NFP+ + W A+ CGN + K A T L ++ V +I Sbjct: 153 IEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVL 212 Query: 211 EAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGK----LIKEAAGKSNLKRV 266 E PG + + G G A++ ++ ++FTGST+VGK +++E G+S Sbjct: 213 EDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRS----- 267 Query: 267 TLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVER 326 LELGG + I DADL V A GQ C A R+F+ ESI+DE V R + Sbjct: 268 LLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKA 327 Query: 327 AKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTV 386 + +GNP P V GP K+ L +E KKEG + GG G +V+PT+ Sbjct: 328 YAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTI 387 Query: 387 FSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSA 446 + + + IA E F P+ + KFK+ ++V N GLS+ +FTKD+ + Sbjct: 388 VTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFR---- 443 Query: 447 LQAGTVWVNCYGVVSAQCP---------FGGFKMSGNGRELGEYGFHEYTEVKTVTVKIS 497 G +C G+V+ P FGG K +G GRE G + +Y T T+ S Sbjct: 444 -WLGPKGSDC-GIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYS 501 Query: 498 Q 498 + Sbjct: 502 K 502 >4KNA-A nrPDB Length = 495 Score = 200 bits (509), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 150/464 (32%), Positives = 218/464 (46%), Gaps = 20/464 (4%) Query: 21 TKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80 T++FI+ W D +G F NP T E + + +DV++AV +AR+AF + W + Sbjct: 10 TELFIDGAWVDG-AGPVFASRNPGTNERVWEGASASADDVERAVASARRAF---AAWSAL 65 Query: 81 DASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI 140 D R ++ + A L+ + LATM GK A + K + ++ Sbjct: 66 DLDARCTIVKRFAALLVERKEALATMIGRETGKPLWEARTEVASMAAKVDISITAYHERT 125 Query: 141 QGRTIPI-DGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP 199 + P+ DG RH P GV P+NFP + I PAL GNTVV KP+E P Sbjct: 126 GEKRAPMADG--VAVLRHRPHGVVAVFGPYNFPGHLPNGHIVPALIAGNTVVFKPSELAP 183 Query: 200 LTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAG 259 A + ++AG P GV+N+V G T G A+++H ID + FTGS++ G L+ + G Sbjct: 184 GVARATVEIWRDAGLPAGVLNLVQGEKDT-GVALANHRQIDGLFFTGSSDTGTLLHKQFG 242 Query: 260 KSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY-DE 318 + LE+GG +P +V D+D AV A F GQ C A RI V + D Sbjct: 243 GRPEIVLALEMGGNNPLVVAEVEDIDAAVHHAIQSAFLSAGQRCTCARRILVPRGAFGDR 302 Query: 319 FVRRSVERAKKYILGN-PLTPGVTQGPQIDKEQYDKIL----DLIESGKKEGAKLECGGG 373 FV R + A K P G I +++ L+ G +++ Sbjct: 303 FVARLADVASKITASVFDADPQPFMGAVISARAASRLVAAQARLVGLGASPIIEMKQRDP 362 Query: 374 PWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVF 433 G FV + +VT+ + EE FGP+ QI+++ LDD I RAN+T +GLSAG+ Sbjct: 363 ALG----FVNAAIL-DVTNVRELPDEEHFGPLAQIVRYTDLDDAIARANDTAFGLSAGLL 417 Query: 434 TKDIDKAITISSALQAGTV-WVNCYGVVSAQCPFGGFKMSGNGR 476 D T A++AG V W S+ PFGG SGN R Sbjct: 418 ADDEQAWHTFRRAIRAGIVNWNRPTNGASSAAPFGGAGRSGNHR 461 >5JRY-A nrPDB Length = 485 Score = 198 bits (503), Expect = 5e-51, Method: Compositional matrix adjust. Identities = 139/431 (32%), Positives = 211/431 (48%), Gaps = 22/431 (5%) Query: 76 PWRTMDASERGRLL-YKLADLIER-DRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYC 133 P R + A +R +L + +A ER D L A + GK ++A ++ I T R Sbjct: 64 PMRELPAYKRQAVLDHCVARFRERFDEL--AEALCIEAGKPINDAK-GEVTRLIDTFRVA 120 Query: 134 AGWADKIQGRTIPID-----GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGN 188 + A +I G + ++ + YTR PIG C I P+NFPL + K+ PAL+ G Sbjct: 121 SEEAVRIDGEVLNLEISARAQGYTGYTRRVPIGPCSFISPFNFPLNLAAHKVAPALAAGC 180 Query: 189 TVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMD-IDKVAFTGS 247 V+KPA +TP+ AL + ++ E P G +++P + GA + + D ++FTGS Sbjct: 181 PFVLKPASRTPVGALIIGEVLAETDLPKGAFSVLPAH--RDGADLFTTDDRFRLLSFTGS 238 Query: 248 TEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADA--DLDNAVEFAHHGVFYHQGQCCIA 305 VG +KE AGK K+V LELGG + IV AD LD V+ G FY GQ CI Sbjct: 239 PAVGWALKEKAGK---KKVVLELGGNAAAIVDADQLDRLDYVVDRLAFGAFYQSGQSCIG 295 Query: 306 ASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEG 365 RI IYD + + + + +G+P P GP I + + ++ +++ G Sbjct: 296 VQRILAHADIYDALRDKLIAKTRSLKMGDPKDPSTFVGPMISESESRRLSGWMDAAVAAG 355 Query: 366 AKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTF 425 AK+ GG G + T+ NV + + ++E FGP+ + KF DD + R N++ Sbjct: 356 AKIVAGG---KVDGAMFEATLLENVGRDQDLYRKEAFGPIAILEKFDRFDDALARVNDSD 412 Query: 426 YGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSA-QCPFGGFKMSGNGRELGEYGFH 484 +GL AGVFT + L+ G V +N P+GG K SG GRE Y Sbjct: 413 FGLQAGVFTDSLAHTQQAWDELEVGGVVINDVPSFRVDNMPYGGVKDSGLGREGIRYAIE 472 Query: 485 EYTEVKTVTVK 495 + TE + + V+ Sbjct: 473 DMTEPRLLVVR 483 >4I3V-A nrPDB Length = 488 Score = 197 bits (501), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 125/347 (36%), Positives = 181/347 (52%), Gaps = 12/347 (3%) Query: 154 YTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAG 213 +T EP+ I P+N PL M+ K+ PA++ N VVVKP E TP+TAL +A ++ EAG Sbjct: 145 FTMREPLTAISAITPFNHPLNMVAHKVAPAIATNNCVVVKPTELTPMTALLLADILYEAG 204 Query: 214 FPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGK 273 PP ++++V G+ G + ++ +D V FTGS VGKLI A ++ KR LELGG Sbjct: 205 LPPEMLSVVTGWPADIGMEMITNPHVDLVTFTGSVPVGKLI---AANAHYKRQVLELGGN 261 Query: 274 SPCIV---LADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKY 330 P I+ L+D DL A + A G + GQ C A RI +ES+ D FV +ERAK+ Sbjct: 262 DPLIILNDLSDDDLARAADLAVAGATKNSGQRCTAVKRILCQESVADRFVPLVLERAKRL 321 Query: 331 ILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNV 390 G+P+ G I ++ + + +EGA + G G + P V V Sbjct: 322 RFGDPMDRSTDLGTVIHEKAAALFEERVMRAAEEGADILYHP---GRSGALLPPIVVDRV 378 Query: 391 TDEMRIAKEEIFGPVQQIMKFKSLDD-VIKRANNTFYGLSAGVFTKDIDKAITISSALQA 449 + + EE FGP+ I++ DD I +N+T +GLS+GV T D + + L+ Sbjct: 379 PHQSDLVLEETFGPIIPIVRVPDDDDATITLSNSTAFGLSSGVCTNDYRRMQKYIAGLKV 438 Query: 450 GTVWV-NCYGVVSAQCPFGGFKMSGNGRELGEY-GFHEYTEVKTVTV 494 GTV + G PFGG K SGNG + G +T VKT ++ Sbjct: 439 GTVNIWEVPGYRIEMSPFGGIKDSGNGYKEGVIEAMKSFTNVKTFSL 485 >4PXN-A nrPDB Length = 525 Score = 195 bits (496), Expect = 4e-50, Method: Compositional matrix adjust. Identities = 141/480 (29%), Positives = 222/480 (46%), Gaps = 35/480 (7%) Query: 34 SGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLA 93 SG +P + + +V E D ++ ++A F W + A +RG ++ ++ Sbjct: 49 SGPTVTSTSPTNNQVIAEVVEASVHDYEEGMRAC---FDAAKTWMAIPAPKRGEIVRQIG 105 Query: 94 DLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDG-NFF 152 D + L + S+ GK+ + ++ I Y G + ++ G IP + N Sbjct: 106 DALRAKLHHLGRLVSLEMGKILPEG-IGEVQEIIDMCDYAVGLSRQLNGSIIPSERPNHM 164 Query: 153 TYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALH----VASL 208 P+GV G I +NFP +L W AL CGN VV K A TPL + VAS+ Sbjct: 165 MMEVWNPLGVVGVITAFNFPCAVLGWNACIALVCGNCVVWKGAPTTPLITIAMTKIVASV 224 Query: 209 IKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTL 268 +++ P + G G G AI+ + I V+FTGST G ++++ + + L Sbjct: 225 LEKNNLPGAIFTSFCG-GTEIGQAIALDIRIPLVSFTGSTRAGLMVQQQV-SARFGKCLL 282 Query: 269 ELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAK 328 EL G + IV+ DAD+ AV GQ C R+ + E+IY F+ + VE K Sbjct: 283 ELSGNNAIIVMDDADIQLAVRSVLFAAVGTAGQRCTTCRRLILHENIYQTFLDQLVEVYK 342 Query: 329 KYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFS 388 + +G+PL G GP + L I++ K +G K+ GG ++G FVQPT+ Sbjct: 343 QVRIGDPLEKGTLLGPLHTPASKENFLKGIQTIKSQGGKILFGGSAIESEGNFVQPTIVE 402 Query: 389 NVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQ 448 +T + KEE+FGPV +MKF++L + I+ N+ GLS+ +FTK D Sbjct: 403 -ITPSAPVVKEELFGPVLYVMKFQTLKEAIEINNSVPQGLSSSIFTKRPDIIFK------ 455 Query: 449 AGTVWVNCY----GVVSAQCP---------FGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495 W+ + G+V+ P FGG K +G GRE G + +Y T T+ Sbjct: 456 ----WLGPHGSDCGIVNVNIPTNGAEIGGAFGGEKATGGGREAGSDSWKQYMRRATCTIN 511 >5U0M-A nrPDB Length = 497 Score = 189 bits (480), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 148/467 (31%), Positives = 212/467 (45%), Gaps = 19/467 (4%) Query: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 ++I+ W G F P T E + EDVD AV+ AR+AF WR Sbjct: 13 NVYIDGLWLPG-HGAPFESVQPVTGETVWDGNAASLEDVDAAVREARKAFLA---WRRKS 68 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 +ER ++ +L+E ++ LA + GK + ++A + + ++ Sbjct: 69 LAERQAVIEAFGELLEANKEELAHQIGLETGKPLWESR-TEVAAMMGKIPISVKAYNERT 127 Query: 142 GRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLT 201 G T RH P GV P+NFP + I PAL GNTVV KP+E TP Sbjct: 128 GHTESDVAGGHAVLRHRPHGVVAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSELTPGV 187 Query: 202 ALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKS 261 A L ++AG P GV+N+V G G G ++ H ID + FTGS+ VG L+ E G Sbjct: 188 AELTVRLWEKAGLPDGVINLVQG-GSDTGKCLARHSLIDGLFFTGSSTVGHLLHEQFGGQ 246 Query: 262 NLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY-DEFV 320 K + LE+GG +P IV +DLD AV A F GQ C A R+ V + DEF+ Sbjct: 247 PEKILALEMGGNNPLIVQNVSDLDGAVHHALQSAFLSAGQRCTCARRLLVPKGKKGDEFL 306 Query: 321 RRSVERAKKYILGN-PLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKG 379 R VE A + + P G I E +++L K + A LE G Sbjct: 307 ARLVEVAARITVAEFDADPQPFMGSVISAEAANQLL------KAQAAMLEKGATSLLEMK 360 Query: 380 YFVQPT--VFSNVTDE--MRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435 T + + D + + +E FGP+ + ++K D+ ++ ANNT YGLSAG+ + Sbjct: 361 QLKPDTGLLSPGIVDATGIELEDQEFFGPLLTVYRYKGFDEALELANNTRYGLSAGILSD 420 Query: 436 DIDKAITISSALQAGTV-WVNCYGVVSAQCPFGGFKMSGNGRELGEY 481 D + ++AG V W S+ PFGG SGN R Y Sbjct: 421 DRKLYNRLVEEVRAGIVNWNRPLTGASSAAPFGGVGASGNHRPSAYY 467 >5J6B-A nrPDB Length = 485 Score = 184 bits (468), Expect = 6e-47, Method: Compositional matrix adjust. Identities = 123/388 (31%), Positives = 186/388 (47%), Gaps = 19/388 (4%) Query: 120 LNDLAG----CIKTLRYCAGWADKIQGRTI-----PIDGNFFTYTRHEPIGVCGQIIPWN 170 +ND G I T R A + +I+G + P + Y + PIG C I P+N Sbjct: 103 INDSKGEVTRLIDTFRVAAEESVRIEGGLVNLEISPRAQGYSGYYKRVPIGPCSFISPFN 162 Query: 171 FPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAG 230 FPL + K+ PAL+ G V+KPA +TP+ AL + ++ E P G +I+P + A Sbjct: 163 FPLNLAAHKVAPALAAGCPFVLKPASRTPIGALIIGEVLAETDLPKGAFSILPAHRDGAD 222 Query: 231 AAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADAD--LDNAV 288 ++ ++FTGS VG E K+ K+V LELGG + IV AD LD V Sbjct: 223 -LFTTDERFKLLSFTGSPTVG---WELKKKAGKKKVVLELGGNAAAIVDADQREVLDYVV 278 Query: 289 EFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDK 348 E G +Y GQ CI RI +YD + + + + +G+P P GP I + Sbjct: 279 ERLAFGAYYQSGQSCIGVQRIIAHADVYDALREKLIAKTRSLKMGDPKDPATFVGPMISE 338 Query: 349 EQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQI 408 + ++ +E+ GAK+ GG G + T+ V + + ++E FGPV + Sbjct: 339 SEARRLAGWMEAAVAAGAKIVAGG---KVDGAMFEATLLEGVGRDQDLYRKEAFGPVALL 395 Query: 409 MKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSA-QCPFG 467 +F DD + R N++ +GL AGVFT + A L+ G V +N P+G Sbjct: 396 ERFSDFDDALARVNDSDFGLQAGVFTDSLSHAQRAWDELEVGGVVINDVPSFRVDNMPYG 455 Query: 468 GFKMSGNGRELGEYGFHEYTEVKTVTVK 495 G K SG GRE Y + TE++ + V+ Sbjct: 456 GVKDSGLGREGIRYAIEDMTELRLMVVR 483 >4E4G-A nrPDB Length = 521 Score = 181 bits (460), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 144/486 (29%), Positives = 228/486 (46%), Gaps = 25/486 (5%) Query: 24 FINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDAS 83 FI+ + SG+ +FNPAT E V A A W + Sbjct: 30 FIDGKRVAGTSGRVSNIFNPATGEVQGTVA---LASDADLAAAVESAKAAQPKWAATNPQ 86 Query: 84 ERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGW-----AD 138 R R+ K L+ + LA M S GK +A D+ ++ + G ++ Sbjct: 87 RRARVFMKFVQLLNDNMNELAEMLSREHGKTIDDAK-GDIVRGLEVCEFVIGIPHLQKSE 145 Query: 139 KIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQT 198 +G ID Y+ +P+G+ I P+NFP ++ +W PA++CGN ++KP+E+ Sbjct: 146 FTEGAGPGID----MYSIRQPVGIGAGITPFNFPGMIPMWMFAPAIACGNAFILKPSERD 201 Query: 199 PLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAA 258 P + +A L+ EAG P G++N+V G A AI +H DI V+F GST + + + A Sbjct: 202 PSVPIRLAELMIEAGLPAGILNVVNG-DKGAVDAILTHPDIAAVSFVGSTPIARYVYGTA 260 Query: 259 GKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAAS-RIFVEESIYD 317 N KR G K+ I++ DADLD A + G+ C+A S + V E + Sbjct: 261 AM-NGKRAQCFGGAKNHMIIMPDADLDQAANALIGAGYGSAGERCMAISVAVPVGEETAN 319 Query: 318 EFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGN 377 + + V + +G GP + KE +I LI+SG ++GAKL G + Sbjct: 320 RLIDKLVPMVESLRIGPYTDEKADMGPVVTKEAEQRIRSLIDSGIEQGAKLVVDGRDFKL 379 Query: 378 KGY----FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVF 433 +GY F+ +F +VT +M I K EIFGPV +++ ++ ++ + YG ++ Sbjct: 380 QGYENGHFIGGCLFDDVTPDMDIYKTEIFGPVLSVVRARNYEEALSLPMKHEYGNGVAIY 439 Query: 434 TKDIDKAITISSALQAGTVWVNC-YGVVSAQCPFGGFKMSGNGRELGEYGFHE---YTEV 489 T+D D A +S + G V VN V A FGG+K S G +L ++G +T Sbjct: 440 TRDGDAARDFASRINIGMVGVNVPIPVPLAYHSFGGWKSSSFG-DLNQHGTDSIKFWTRT 498 Query: 490 KTVTVK 495 KT+T + Sbjct: 499 KTITSR 504 >6DBB-A nrPDB Length = 511 Score = 177 bits (448), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 138/485 (28%), Positives = 224/485 (46%), Gaps = 31/485 (6%) Query: 35 GKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLAD 94 G +P L + D ++ + AA AF WRT+ A RG L+ + Sbjct: 27 GNALTARSPLDGATLATLAVDTPADAERKIDAAHDAFL---KWRTVPAPVRGELVRVFGN 83 Query: 95 LIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPID--GNFF 152 ++ + L + ++ GK+ S L ++ I + G + ++ G TI + G+ Sbjct: 84 VLREHKAELGRLVTLEAGKITSEG-LGEVQEMIDICDFAVGLSRQLYGLTIASERPGHRM 142 Query: 153 TYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEA 212 T H PIGVCG I +NFP+ + W A CG++VV KP+E+TPLTA+ L+++A Sbjct: 143 METWH-PIGVCGVISAFNFPVAVWAWNAALAFVCGDSVVWKPSEKTPLTAIACHVLLQKA 201 Query: 213 ---------GFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNL 263 G P + + G +++ + V+ TGS +G+ + + + L Sbjct: 202 LREFEKTHPGVAPAELGQLVLGMRDVGEVLTASKKVPVVSATGSVRMGQEVAKVLSQ-RL 260 Query: 264 KRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRS 323 R LELGG + IV ADLD V GQ C R+ V S+ ++ + R Sbjct: 261 ARGILELGGNNGMIVAPSADLDLVVRAVTFAAVGTAGQRCTTLRRLIVHRSLVEQLLPR- 319 Query: 324 VERAKKYI-LGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKG--- 379 +E+A + +GNPL G GP +D+ +D + + +++G E GG + G Sbjct: 320 IEKAYASVKVGNPLEEGTLVGPLVDRASFDAMQKALADAREQGG--EVKGGERVDVGHAD 377 Query: 380 -YFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDID 438 Y+V+P + + + + + E F P+ +M + + DD I N GLS+ +FT D+ Sbjct: 378 AYYVRPAIV-RMPKQSAVVERETFAPILYVMVYDNFDDAIDVHNAVPQGLSSAIFTNDMR 436 Query: 439 KAITISSAL--QAGTVWVNCYGVVSAQC--PFGGFKMSGNGRELGEYGFHEYTEVKTVTV 494 +A SA G V VN G A+ FGG K +G GRE G + Y T T+ Sbjct: 437 EAEQFMSAAGSDCGIVNVNI-GTSGAEIGGAFGGEKETGGGRESGSDAWKAYMRRATNTI 495 Query: 495 KISQK 499 S++ Sbjct: 496 NYSRQ 500 >4H7N-A nrPDB Length = 474 Score = 174 bits (440), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 116/347 (33%), Positives = 176/347 (50%), Gaps = 20/347 (5%) Query: 159 PIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP------LTALHVASLIKEA 212 P + G I PWNFPL + + PAL G VVVKP+E P L AL+ +++ Sbjct: 126 PYPLVGVISPWNFPLTLSMIDTIPALLAGCAVVVKPSEIAPRFVAPLLMALNTVPELRD- 184 Query: 213 GFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGG 272 V+ V G G T GA + +++D V FTGS G+ + E A + + LELGG Sbjct: 185 -----VLIFVEGGGET-GANLINYVDF--VCFTGSVATGREVAETAARRFIP-AYLELGG 235 Query: 273 KSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYIL 332 K P IVL A+L+ A G + GQ C++ RI+V ES ++EF + + +A + L Sbjct: 236 KDPAIVLESANLELATSAILWGAVVNTGQSCLSIERIYVAESKFEEFYHQLIAKAHRLQL 295 Query: 333 GNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG-NKGYFVQPTVFSNVT 391 PL GP I ++Q I D I ++GA + CGG G++ +PTV +NV Sbjct: 296 AYPLVEDGAIGPIIAEKQAGIINDHILDAVEKGAVIHCGGKVEELGGGWWCRPTVMTNVN 355 Query: 392 DEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGT 451 M++ EE FGP+ +M F +++ + AN+T YGLSA VF D+A+ ++ L AG Sbjct: 356 HSMKVMTEETFGPIMPVMPFPDVEEAVYLANDTIYGLSAAVFAGSEDEALKVARQLNAGA 415 Query: 452 VWVNCYGVVSA--QCPFGGFKMSG-NGRELGEYGFHEYTEVKTVTVK 495 + +N + + + F SG G +G G + + +K Sbjct: 416 ISINDAALTAMMHEGEKNAFNFSGLGGSRVGAAGLKRFLRKQAFLIK 462 >1AD3-A nrPDB Length = 452 Score = 157 bits (396), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 132/452 (29%), Positives = 213/452 (47%), Gaps = 40/452 (8%) Query: 60 VDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNG------GK 113 + VK AR+AF G + L +++ L R++ ++S++G GK Sbjct: 3 ISDTVKRAREAFNSG---------KTRSLQFRIQQLEALQRMINENLKSISGALASDLGK 53 Query: 114 LYSNAYLNDLAGCIK----TLRYCAGWA-DKIQGRTIPIDGNFFTYTRHEPIGVCGQIIP 168 +Y ++A ++ T++ WA D+ +T + Y EP+GV I Sbjct: 54 NEWTSYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGA 112 Query: 169 WNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPT 228 WN+P + I + A++ GN V++KP+E + A +A+LI + + +V G P Sbjct: 113 WNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPE 171 Query: 229 AGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAV 288 + D + +TGST VGK++ AA K +L VTLELGGKSPC V D DLD A Sbjct: 172 TTELLKERFD--HIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVAC 228 Query: 289 EFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDK 348 G F + GQ C+A I + SI ++ V + ++++ K G G I+ Sbjct: 229 RRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKDFYGEDAKQSRDYGRIIND 287 Query: 349 EQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQI 408 + ++ LI++ K GG W ++ PT+ +V + + +EEIFGPV I Sbjct: 288 RHFQRVKGLIDNQKV------AHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPI 341 Query: 409 MKFKSLDDVIKRANNTFYGLSAGVFT---KDIDKAI--TISSALQAGTVWVNCYGVVSAQ 463 + +SL++ I+ N L+ VF+ K I K I T S + A V V+ + Sbjct: 342 VCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVH---ITVPT 398 Query: 464 CPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495 PFGG SG G G+ F ++ ++ VK Sbjct: 399 LPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 430 >5UCD-A nrPDB Length = 457 Score = 154 bits (389), Expect = 8e-38, Method: Compositional matrix adjust. Identities = 127/427 (29%), Positives = 203/427 (47%), Gaps = 28/427 (6%) Query: 79 TMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWAD 138 T D R + L +L + + ++ L + + + GK L ++ + + + D Sbjct: 46 TADVGFRKQSLERLKEAVINNKEALYSALAEDLGKPKDVVDLAEIGAVLHEIDFALAHLD 105 Query: 139 K-IQGRTIP---IDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKP 194 + + ++P I Y EP GV I P+N+P+ + + + A+ GNT ++KP Sbjct: 106 EWVAPVSVPSPDIIAPSECYVVQEPYGVTYIIGPFNYPVNLTLTPLIGAIIGGNTCIIKP 165 Query: 195 AEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHM---DIDKVAFTGSTEVG 251 +E TP T+ + +I EA F P V ++ G G +SH+ D + FTGS VG Sbjct: 166 SETTPETSAVIEKIIAEA-FAPEYVAVIQG-----GRDENSHLLSLPFDFIFFTGSPNVG 219 Query: 252 KLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFV 311 K++ +AA K +L V LELGGK P IVL DADLD V G F + GQ IA ++V Sbjct: 220 KVVMQAAAK-HLTPVVLELGGKCPLIVLPDADLDQTVNQLMFGKFINSGQTXIAPDYLYV 278 Query: 312 EESIYDEFVRRSVERAKKYILGNPLTPGV-TQGPQIDKEQYDKILDLIESGKKEGAKLEC 370 S+ D + R VER K + P + + G + + Q +++ L+E+ +G L Sbjct: 279 HYSVKDALLERLVERVKTEL------PEINSTGKLVTERQVQRLVSLLEA--TQGQVLVG 330 Query: 371 GGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTF-YGLS 429 + + TV V + EE+FGP+ +++F S+ I + N L+ Sbjct: 331 SQADVSKRA--LSATVVDGVEWNDPLMSEELFGPILPVLEFDSVRTAIDQVNKHHPKPLA 388 Query: 430 AGVFTKDIDKAITISSALQAGTVWVN--CYGVVSAQCPFGGFKMSGNGRELGEYGFHEYT 487 VF KD+D A I + +Q+G VN S PFGG SG G G + + +T Sbjct: 389 VYVFGKDMDVAKGIINQIQSGDAQVNGVMLHAFSPYLPFGGIGASGMGEYHGHFSYLTFT 448 Query: 488 EVKTVTV 494 K+V + Sbjct: 449 HKKSVRI 455 >3SZA-A nrPDB Length = 469 Score = 154 bits (389), Expect = 9e-38, Method: Compositional matrix adjust. Identities = 133/447 (29%), Positives = 208/447 (46%), Gaps = 30/447 (6%) Query: 60 VDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAY 119 + +AVK AR AF G RT R + L L LI+ L + + K NAY Sbjct: 20 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 76 Query: 120 LNDLAGCIKTLRY----CAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVM 175 ++ ++ + Y WA P Y EP+GV I WN+P + Sbjct: 77 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 136 Query: 176 LIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISS 235 I + A++ GN VV+KP+E + A +A++I + + ++ G P + Sbjct: 137 TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 195 Query: 236 HMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGV 295 D + +TGST VGK+I AA K +L VTLELGGKSPC V + DLD A G Sbjct: 196 RFD--HILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 252 Query: 296 FYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKIL 355 F + GQ C+A I + SI ++ V + ++++ K G G I + +++ Sbjct: 253 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 311 Query: 356 DLIESGKKEGAKLECGG-GPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSL 414 LI EG K+ GG G + ++ PT+ ++V + + +EEIFGPV I+ +SL Sbjct: 312 GLI-----EGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 364 Query: 415 DDVIKRANNTFYGLSAGVFTKDIDKAI------TISSALQAGTVWVNCYGVVSAQCPFGG 468 ++ I+ N L+ +F+ + DK I T S + A V V+ + PFGG Sbjct: 365 EEAIQFINQREKPLALYMFSSN-DKVIKKMIAETSSGGVAANDVIVH---ITLHSLPFGG 420 Query: 469 FKMSGNGRELGEYGFHEYTEVKTVTVK 495 SG G G+ F ++ ++ V+ Sbjct: 421 VGNSGMGSYHGKKSFETFSHRRSCLVR 447 >4LGZ-A nrPDB Length = 563 Score = 153 bits (387), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 143/506 (28%), Positives = 230/506 (45%), Gaps = 42/506 (8%) Query: 3 SSGTPDLPVL---LTDLKIQYTKI--FINNE--WHDSVSGKKFPVFNPATEEELCQVEEG 55 S G+P+ L L DLK Q I + +E W + + P FN A ++ + Sbjct: 41 SQGSPERDALQKALKDLKGQTEAIPCVVGDEEVWTSDIQYQLSP-FNHA--HKVAKFCYA 97 Query: 56 DKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNG-GKL 114 DK +++A+ AA A + W ++R ++ K AD++ R ++M G GK Sbjct: 98 DKALLNRAIDAALAARK---EWDLKPMADRAQVFLKAADMLSGPRRAEVLAKTMVGQGKT 154 Query: 115 YSNAYLNDLAGCIKTLRYCAGWADKIQGR---TIPIDGNFFTYTRHEPIGVCGQIIPWNF 171 A ++ A I R+ A +A +++G ++P N Y E G I P+NF Sbjct: 155 VIQAEIDAAAELIDFFRFNAKFAVELEGEQPISVPPSTNHTVYRGLE--GFVAAISPFNF 212 Query: 172 PLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGA 231 + PAL GN V+ KP++ L + V +++EAG PP ++ VP GPT G Sbjct: 213 TAIGGNLAGAPAL-MGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPTFGD 271 Query: 232 AISSHMDIDKVAFTGSTEVGKLIKEAAGKS-----NLKRVTLELGGKSPCIVLADADLDN 286 ++S + + FTGS K + ++ R+ E GGK+ V + AD+D+ Sbjct: 272 TVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKNFHFVHSSADVDS 331 Query: 287 AVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTP-GVTQGPQ 345 V F + GQ C A SR++V +S++ + R +E + +G+P G Sbjct: 332 VVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAV 391 Query: 346 IDKEQYDKILDLIESGKKEGAKLECGGGPWGNK-GYFVQPTVFSNVTDEMRIAKEEIFGP 404 ID + + +I +E + + GG GY+V+P + + + I KEEIFGP Sbjct: 392 IDAKAFARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIESKDPQEPIMKEEIFGP 451 Query: 405 VQQIMKFKSLDDVIKRA-----NNTFYGLSAGVFTKDIDKAITISSALQ----AGTVWVN 455 V + + DD + + T YGL+ VF + DKAI + AG ++N Sbjct: 452 VLTVYVYP--DDKYRETLKLVDSTTSYGLTGAVFAQ--DKAIVQEATRMLRNAAGNFYIN 507 Query: 456 --CYGVVSAQCPFGGFKMSGNGRELG 479 G V Q PFGG + SG + G Sbjct: 508 DKSTGSVVGQQPFGGARASGTNDKPG 533 >3V9H-A nrPDB Length = 566 Score = 152 bits (385), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 141/504 (27%), Positives = 229/504 (45%), Gaps = 38/504 (7%) Query: 3 SSGTPDLPVL---LTDLKIQYTKI--FINNE--WHDSVSGKKFPVFNPATEEELCQVEEG 55 + G+P+ L L DLK + I + +E W V + P + + C Sbjct: 44 TQGSPERDALQKALKDLKGRMEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCY---A 100 Query: 56 DKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNG-GKL 114 DK ++KA++AA A + W ++R ++ K AD++ R ++M G GK Sbjct: 101 DKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKT 157 Query: 115 YSNAYLNDLAGCIKTLRYCAGWADKIQGR---TIPIDGNFFTYTRHEPIGVCGQIIPWNF 171 A ++ A I R+ A +A +++G+ ++P N Y E G I P+NF Sbjct: 158 VIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--GFVAAISPFNF 215 Query: 172 PLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGA 231 + PAL GN V+ KP++ L + V +++EAG PP ++ VP GP G Sbjct: 216 TAIGGNLAGAPAL-MGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGD 274 Query: 232 AISSHMDIDKVAFTGSTEVGK-LIKEAAGK----SNLKRVTLELGGKSPCIVLADADLDN 286 ++S + + FTGS K L K+ A R+ E GGK+ V AD+++ Sbjct: 275 TVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVES 334 Query: 287 AVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTP-GVTQGPQ 345 V F + GQ C A +R++V S++ + R +E + +G+P G Sbjct: 335 VVSGTLRSAFEYGGQKCSACARLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAV 394 Query: 346 IDKEQYDKILDLIESGKKEGAKLECGGGPWGNK-GYFVQPTVFSNVTDEMRIAKEEIFGP 404 ID + + +I +E + + GG + GYFV+P + + + I KEEIFGP Sbjct: 395 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGP 454 Query: 405 VQQIMKFKSLDDVIKRA-----NNTFYGLSAGVFTKDIDKAITISSALQ--AGTVWVN-- 455 V + + DD K + T YGL+ VF++D D + L+ AG ++N Sbjct: 455 VLSVYVYP--DDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDK 512 Query: 456 CYGVVSAQCPFGGFKMSGNGRELG 479 G + Q PFGG + SG + G Sbjct: 513 STGSIVGQQPFGGARASGTNDKPG 536 >4OE4-A nrPDB Length = 580 Score = 152 bits (385), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 148/499 (29%), Positives = 234/499 (46%), Gaps = 52/499 (10%) Query: 16 LKIQYTKIFINNEWHDSVSGKKFPVFNPATEEE-LCQVEEGDKEDVDKAVKAARQAFQIG 74 L I +I+ NNE FP NPA ++ L V + ++DV + A + A Sbjct: 62 LVINGERIYDNNE------RALFPQTNPANHQQVLANVTQATEKDV---MNAVKAAKDAK 112 Query: 75 SPWRTMDASERGRLLYKLADLIE---RDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLR 131 W + +R + K ADLI R +L ATM + GK A ++ + R Sbjct: 113 KDWYNLPFYDRSAIFLKAADLISTKYRYDMLAATM--LGQGKNVYQAEIDCITELSDFFR 170 Query: 132 YCAGWADKIQGRTIPIDGNFFTYTRHE--PI-GVCGQIIPWNFPLVMLIWKIGPALSCGN 188 Y +A + + P++ T+ + E P+ G + P+NF + PAL GN Sbjct: 171 YYVKYASDLYAQQ-PVESADGTWNKAEYRPLEGFVYAVSPFNFTAIAANLIGAPAL-MGN 228 Query: 189 TVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGST 248 TVV KP++ L+ + ++++EAG P GV+N +PG + + D + FTGST Sbjct: 229 TVVWKPSQTAALSNYLLMTVLEEAGLPKGVINFIPGDPVQVTDQVLADKDFGALHFTGST 288 Query: 249 EVGKLI--KEAAG-----KSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQ 301 V K + K +G + R+ E GGK+ +V A++ +AV G F QGQ Sbjct: 289 NVFKSLYGKIQSGVVEGKYRDYPRIIGETGGKNFHLVHPSANISHAVLSTIRGTFEFQGQ 348 Query: 302 CCIAASRIFVEESIYDEF------VRRSVERAKKYILGNPLTPGVTQ---GPQIDKEQYD 352 C AASR+++ ES +EF + +S +P++ G + GP I ++ +D Sbjct: 349 KCSAASRLYLPESKSEEFLSDMFGILQSQNVVPMNTSASPISGGNLRGFMGPVIHEQSFD 408 Query: 353 KILDLIESGKKEGAKLEC--GGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIM- 409 K++ +IE KK+ +LE GG ++G+FV PTV + E FGP+ + Sbjct: 409 KLVKVIEDAKKD-PELEILYGGQYDKSQGWFVGPTVIKAKRPDHPYMSTEFFGPILTVYE 467 Query: 410 ----KFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISS---ALQAGTVWVN--CYGVV 460 +F + D+I N + Y L+ +F KD KAI + AG ++N C G V Sbjct: 468 YPDTEFNEICDIID--NTSQYALTGAIFAKD-RKAIEYADEKLKFSAGNFYINDKCTGAV 524 Query: 461 SAQCPFGGFKMSGNGRELG 479 +Q FGG +MSG + G Sbjct: 525 VSQQWFGGARMSGTDDKAG 543 >3JU8-A nrPDB Length = 490 Score = 152 bits (383), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 132/462 (28%), Positives = 201/462 (43%), Gaps = 22/462 (4%) Query: 24 FINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDAS 83 +I +W G+ +P + + D VD AV AAR+AF W Sbjct: 9 YIAGQWLAG-QGETLESLDPVGQGVVWSGRGADATQVDAAVCAAREAFPA---WARRPLE 64 Query: 84 ERGRLLYKLA-DLIERDRLLLATMESMNGGKLYSNA-----YLNDLAGCIKTLRYCAGWA 137 +R LL + A L R L + G L+ +A +N +A ++ R Sbjct: 65 QRIELLERFAATLKSRADELARVIGEETGKPLWESATEVTSMVNKVAISVQAFR------ 118 Query: 138 DKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQ 197 ++ ++ P+ + RH+P GV P+NFP + I PAL GN VV KP+E Sbjct: 119 ERTGEKSGPL-ADATAVLRHKPHGVVAVFGPYNFPGHLPNGHIVPALLAGNCVVFKPSEL 177 Query: 198 TPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEA 257 TP A +AG P GV+N+V G G G A+++H +D + FTGS+ G L+ Sbjct: 178 TPKVAELTLKAWIQAGLPAGVLNLVQG-GRETGVALAAHRGLDGLFFTGSSRTGNLLHSQ 236 Query: 258 AGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY- 316 G K + LE+GG +P +V ADLD AV F GQ C A R+ V + + Sbjct: 237 FGGQPQKILALEMGGNNPLVVEEVADLDAAVYTIIQSAFISAGQRCTCARRLLVPQGAWG 296 Query: 317 DEFVRRSVERAKKYILGN-PLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPW 375 D + R V + +G P G I + +L E +GA+ Sbjct: 297 DALLARLVAVSATLRVGRFDEQPAPFMGAVISLSAAEHLLKAQEHLIGKGAQPLLAMTQP 356 Query: 376 GNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435 + + P + +V+ EE FGP+ Q++++ I+ AN T YGL+AG+ + Sbjct: 357 IDGAALLTPGIL-DVSAVAERPDEEFFGPLLQVIRYSDFAAAIREANATQYGLAAGLLSD 415 Query: 436 DIDKAITISSALQAGTV-WVNCYGVVSAQCPFGGFKMSGNGR 476 ++ +AG V W ++ PFGG SGN R Sbjct: 416 SRERFEQFLVESRAGIVNWNKQLTGAASSAPFGGIGASGNHR 457 >4QGK-A nrPDB Length = 461 Score = 140 bits (352), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 126/447 (28%), Positives = 202/447 (45%), Gaps = 38/447 (8%) Query: 64 VKAARQAFQIGSPWRTMDASERGRLLYKLADLI-ERDRLLLATMES---MNGGKLYSNAY 119 V+ RQAF G R+ R + L L ++ ER++ +L + + + +YS Sbjct: 6 VRRVRQAFLSG---RSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEV 62 Query: 120 LNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFT-----YTRHEPIGVCGQIIPWNFPLV 174 + L L W P+ N T Y + +P+GV I WN+P V Sbjct: 63 ITVLGEIDFMLENLPEWVT-----AKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFV 117 Query: 175 MLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAIS 234 + I + A++ GN V++KP+E + TA +A L+ + + I G T Sbjct: 118 LTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELL-- 175 Query: 235 SHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHG 294 D + +TG+T VGK++ EAA K +L VTLELGGKSPC + D DLD G Sbjct: 176 -KQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWG 233 Query: 295 VFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQ----IDKEQ 350 + + GQ CIA I E S+ ++ V + E K++ N + + P I+ Sbjct: 234 KYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGEN-----IKESPDYERIINLRH 288 Query: 351 YDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMK 410 + +IL L+ EG K+ GG ++ PTV ++V + ++ +EEIFGP+ I+ Sbjct: 289 FKRILSLL-----EGQKIAFGGET-DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVP 342 Query: 411 FKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVN--CYGVVSAQCPFGG 468 K++D+ I N L+ VF+ + + +G V N PFGG Sbjct: 343 VKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGG 402 Query: 469 FKMSGNGRELGEYGFHEYTEVKTVTVK 495 SG G G++ F ++ + +K Sbjct: 403 VGSSGMGAYHGKHSFDTFSHQRPCLLK 429 >4IDS-A nrPDB Length = 563 Score = 122 bits (307), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 121/427 (28%), Positives = 187/427 (43%), Gaps = 30/427 (7%) Query: 75 SPWRTMDASERGRLLYKLADLIE---RDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLR 131 S W + ER + + ADL+ R+++ ATM + K A ++ + I R Sbjct: 113 SDWAALPFDERAAVFLRAADLLAGPWREKIAAATM--LGQSKSVYQAEIDAVCELIDFWR 170 Query: 132 YCAGWADKIQGRTIPIDG-NFFTYTRHEPI-GVCGQIIPWNFPLVMLIWKIGPALSCGNT 189 + +A +I + PI G + + P+ G I P+NF + PAL GNT Sbjct: 171 FNVAFARQILEQQ-PISGPGEWNRIDYRPLDGFVYAITPFNFTSIAGNLPTAPAL-MGNT 228 Query: 190 VVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTE 249 V+ KP+ L A L++ AG PPGV+N+V G G + + + FTGST Sbjct: 229 VIWKPSITQTLAAYLTMQLLEAAGLPPGVINLVTGDGFAVSDVALADPRLAGIHFTGSTA 288 Query: 250 VGKLIKEAAGKS-----NLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCI 304 + + G + + R+ E GGK + A A D G F +QGQ C Sbjct: 289 TFGHLWQWVGTNIGRYHSYPRLVGETGGKDFVVAHASARPDVLRTALIRGAFDYQGQKCS 348 Query: 305 AASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKE 364 A SR F+ S++ + +A + G+ G ID+ + K +D IE K Sbjct: 349 AVSRAFIAHSVWQRMGDELLAKAAELRYGDITDLSNYGGALIDQRAFVKNVDAIERAKGA 408 Query: 365 GAKLECGGGPWGN-KGYFVQPTVF--SNVTDEMRIAKEEIFGPVQQIM-----KFKSLDD 416 A GG + + +GYFV+PTV + TDE + E FGP+ + +++ + D Sbjct: 409 AAVTVAVGGEYDDSEGYFVRPTVLLSDDPTDESFVI--EYFGPLLSVHVYPDERYEQILD 466 Query: 417 VIKRANNTFYGLSAGVFTKDIDKAITISSALQ--AGTVWVN--CYGVVSAQCPFGGFKMS 472 VI + Y L+ V D +T L+ AG +VN G V + PFGG + S Sbjct: 467 VIDTGSR--YALTGAVIADDRQAVLTALDRLRFAAGNFYVNDKPTGAVVGRQPFGGARGS 524 Query: 473 GNGRELG 479 + G Sbjct: 525 DTNDKAG 531 >5NNO-A nrPDB Length = 546 Score = 110 bits (276), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 109/355 (30%), Positives = 174/355 (49%), Gaps = 27/355 (7%) Query: 156 RHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFP 215 ++EP+GV I WN+PL++++ + AL+ GNT V+KP+E P TA + L+ + Sbjct: 114 QYEPLGVVLVIGTWNYPLLLILQPLLGALAAGNTAVIKPSELAPATAELLTKLLPKY-VS 172 Query: 216 PGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSP 275 VV IV G A + D + +TGS V +++ AA K +L VTLELGGKSP Sbjct: 173 SDVVGIVNGGVSETTAVLKERF--DHILYTGSARVAEIVMAAAAK-HLTPVTLELGGKSP 229 Query: 276 CIVLADADLDNAVEFAHH---GVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYIL 332 +V+ D DN A G + GQ IA + VE+S+ V ++ A+K +L Sbjct: 230 -VVVDDTCADNMKVVAERIMWGKIINAGQTSIAPDYVVVEKSMESVLV-DALAEARKAML 287 Query: 333 GNPLTPG------VTQGPQ-IDKEQYDKILD------LIESGKKEGAKLECGGGPWGNKG 379 G+ V Q Q +++ Y +I++ L+E K G K+ GG Sbjct: 288 GDKFLKVLKGELLVKQKQQFLEESDYPRIVNASHFQRLMEFMK--GGKVAV-GGEADEAT 344 Query: 380 YFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDK 439 + PT+ +N+ + +EEIFGP+ ++ +++ D++K N+ L+ VF+ + Sbjct: 345 LTIAPTILTNIDPTHPVMQEEIFGPILPVLTYENEKDILKIINSREKPLALYVFSNNKRF 404 Query: 440 AITISSALQAGTVWVNCYGVVSAQ--CPFGGFKMSGNGRELGEYGFHEYTEVKTV 492 + S +G V VN V + PFGG SG G G Y F ++ + V Sbjct: 405 IRGVESRTSSGAVVVNDVVVHAGADGLPFGGVGRSGMGAYHGRYSFETFSHRRPV 459 >2Y53-A nrPDB Length = 534 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 100/407 (24%), Positives = 168/407 (41%), Gaps = 31/407 (7%) Query: 34 SGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLA 93 +G + +P T L +V + D+ +A AR+ G+ R + ++R L + Sbjct: 20 TGAGITLTDPVTGVALVRVSS-EGLDLARAFSFARE--DGGAALRALTYAQRAARLADIV 76 Query: 94 DLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI---------QGRT 144 L++ R + + N G +++ + D+ G I TL Y A + + Sbjct: 77 KLLQAKRGDYYAIATANSGTTRNDSAV-DIDGGIFTLSYYAKLGASLGEVHALRDGSAES 135 Query: 145 IPIDGNFFTYTRHEPI-GVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP-LTA 202 + D +F P GV I +NFP L K PAL G V+VKPA T LT Sbjct: 136 LSKDRSFSAQHVLSPTRGVALFINAFNFPSWGLWEKAAPALLSGVPVIVKPATATAWLTQ 195 Query: 203 LHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIK-EAAGKS 261 VA ++ PPG ++I+ G ++ + D V+FTGS + ++ A Sbjct: 196 RMVADVVDAGILPPGALSIICG---SSAGLLDQIRSFDVVSFTGSADTAATLRAHPAFVQ 252 Query: 262 NLKRVTLELGGKSPCIVLADADLDNA-----VEFAHHGVFYHQGQCCIAASRIFVEESIY 316 R+ ++ + I+ ADA D ++ + GQ C A R FV E+ Sbjct: 253 RGARLNVQADSLNSAILCADATPDTPAFDLFIKEVVREMTVKSGQKCTAIRRAFVPEAAL 312 Query: 317 DEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGA-KLECGGGPW 375 + + + K +GNP V G + +EQY+ +L I + ++E + P Sbjct: 313 EPVLEALKAKLAKITVGNPRNDAVRMGSLVSREQYENVLAGIAALREEAVLAYDSSAVPL 372 Query: 376 ----GNKGYFVQPTVF-SNVTDEMRIAKE-EIFGPVQQIMKFKSLDD 416 N V P +F N D + + E+FGPV + ++ D Sbjct: 373 IDADANIAACVAPHLFVVNDPDNATLLHDVEVFGPVASVAPYRVTTD 419 >5DBV-A nrPDB Length = 445 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 82/317 (25%), Positives = 126/317 (39%), Gaps = 34/317 (10%) Query: 152 FTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKE 211 T P GV G I P P +I L+ GNTVV P T+ LI E Sbjct: 102 LTLVEMGPFGVIGAITPCTNPSETIICNTIGMLAGGNTVVFNPHPAAIKTSNFAVQLINE 161 Query: 212 AGFPP-GVVNIVPGY-GPTAGAA--ISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVT 267 A G VNI PT ++ + SH DI +A TG V + ++ KR Sbjct: 162 ASLSAGGPVNIACSVRKPTLDSSKIMMSHQDIPLIAATGGPGVVTAVLQSG-----KRGI 216 Query: 268 LELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERA 327 G P +V AD+ A E +G + IA + ++I +E + V+ Sbjct: 217 GAGAGNPPVLVDETADIRKAAEDIINGCTFDNNLPAIAEKEVVAIDAIANELMNYMVKEQ 276 Query: 328 KKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVF 387 Y I KEQ +K+ +L+ + K G C G + V Sbjct: 277 GCY--------------AITKEQQEKLTNLVITPK--GLNRNCVGKDARTLLGMIGIDVP 320 Query: 388 SNVT-------DEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYG--LSAGVFTKDID 438 SN+ E + EE+ P+ I++ KS DD +++A +G SA + +K++D Sbjct: 321 SNIRCIIFEGEKEHPLISEELMMPILGIVRAKSFDDAVEKAVWLEHGNRHSAHIHSKNVD 380 Query: 439 KAITISSALQAGTVWVN 455 + T + A+ + N Sbjct: 381 RITTYAKAIDTAILVKN 397 >3V4C-A nrPDB Length = 528 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 111/472 (23%), Positives = 174/472 (36%), Gaps = 65/472 (13%) Query: 22 KIFINNEWHDSV-SGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80 K + EW D + P PA + + VE V++A +AA +AF W Sbjct: 31 KHLVAGEWLDGAGTFASAPAHGPAHDFAVGTVEL-----VNRACEAAEEAF-----WTYG 80 Query: 81 DAS--ERGRLLYKLADLIERDRLLLATMES---------MNGGKLYSNAYLNDLAGCIKT 129 +S ER L +AD IE + + S +NG + + L A I+ Sbjct: 81 YSSRKERAAFLRAIADEIEARAEAITEIGSQETGLPEARLNGERGRTTGQLRLFADHIEK 140 Query: 130 LRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIW--KIGPALSCG 187 Y D P + P+G NFPL AL+ G Sbjct: 141 GDYLDRRVDAAMPERQPAPRQEIRLVQR-PVGPVAVFGASNFPLAFSTAGGDTAAALAAG 199 Query: 188 NTVVVKPAEQTP----LTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVA 243 VVVK P + A V + I++ G PGV +++ G G A+ H I V Sbjct: 200 CPVVVKGHSAHPGTGEIVAEAVDAAIRKTGVHPGVFSLIQGGSRDVGHALVQHPHIKAVG 259 Query: 244 FTGSTEVGK-LIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHG----VFYH 298 FTGS G+ L A + ELG +P +L +A L E G + Sbjct: 260 FTGSLAGGRALFDLCAARPEPIPFFGELGSVNPMFLLPEA-LKARAETLGQGWAGSLTMG 318 Query: 299 QGQCCIAAS-RIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYD----- 352 GQ C + +E + D F +VE K LT G+ + + + ++ Sbjct: 319 AGQFCTNPGIAVVIEGADADRFTTAAVEALAKVAPQTMLTDGIAKAYRDGQARFATRNAV 378 Query: 353 KILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEM---RIAKEEIFGPVQQIM 409 K L ES ++ + P +F + EE+FGP+ ++ Sbjct: 379 KPLLATESSGRDAS-----------------PNLFETTGAQFLADHALGEEVFGPLGLVV 421 Query: 410 KFKSLDDVIKRANNTFYGLSAGVFTK--DIDKAITISSALQ--AGTVWVNCY 457 + S ++ + A L+A + D++ A + L+ AG V VN + Sbjct: 422 RVGSPAEMEELARGFQGQLTATIHMDAGDLETARRLRPVLERKAGRVLVNGF 473 >6D97-A nrPDB Length = 547 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 74/320 (23%), Positives = 131/320 (40%), Gaps = 36/320 (11%) Query: 139 KIQGRTIPIDGNFF---TYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPA 195 + R+ + GN + P G I P+NFPL + + ++ AL GN V+K Sbjct: 165 RFLARSFAVPGNHLGQRSNGYRWPYGPVAIITPFNFPLEIPLLQLMGALYMGNKPVLKVD 224 Query: 196 EQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVG-KLI 254 + + + L+ + G P ++ + G + + FTGS+ V KL Sbjct: 225 SKVSIVMEQMIRLLHDCGLPAEDMDFINSDGAVMNKLL-LEANPKMTLFTGSSRVAEKLA 283 Query: 255 KEAAGKSNLKRVTLELGGKSPCIVLADA-DLDNAVEFAHHGVFYHQGQCCIAASRIFVEE 313 + G RV LE G I+ D ++D + GQ C A S +F+ + Sbjct: 284 ADLKG-----RVKLEDAGFDWKILGPDVQEVDYVAWVCDQDAYACSGQKCSAQSVLFMHK 338 Query: 314 SIYD----EFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLE 369 + E +++ ER K L + P +T + E + +L K G+K+ Sbjct: 339 NWSSSGLLEKMKKLSERRKLEDLT--IGPVLTVTTEAMIEHMNNLL------KIRGSKVL 390 Query: 370 CGGGPWGNKGY-----FVQPT-VFSNVTDEMR-----IAKEEIFGPVQQIMKFK--SLDD 416 GG P N ++PT VF + + ++ + +EIFGP Q + ++ L+ Sbjct: 391 FGGEPLANHSIPKIYGAMKPTAVFVPLEEILKSGNFELVTKEIFGPFQVVTEYSEDQLEL 450 Query: 417 VIKRANNTFYGLSAGVFTKD 436 V++ L+A + + D Sbjct: 451 VLEACERMNAHLTAAIVSND 470 >5UJU-A nrPDB Length = 576 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 46/168 (27%), Positives = 78/168 (46%), Gaps = 21/168 (12%) Query: 184 LSCGNTVVVKPAEQTPL----TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISS---H 236 L+ GNTV+VKP L T +++EAGF P VV ++ P GA + Sbjct: 229 LATGNTVIVKPHPGAILPLAITVRIARDVLREAGFDPNVVTLL-ATEPNDGALVQDLALR 287 Query: 237 MDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVF 296 +I + FTGST+ G ++ A ++ +V E G + ++ + DL A + + Sbjct: 288 PEIKLIDFTGSTQNGTWLERHAHQA---QVYTEKAGVNQIVIDSTDDLKAAAKNIAFSLA 344 Query: 297 YHQGQCCIAASRIFVE---------ESIYDEFVRRSVERAKKYILGNP 335 + GQ C A I+V + +DE V +++ A + + G+P Sbjct: 345 LYSGQMCTAPQNIYVPRDGIRTADGHASFDE-VAQAIAGAVQKLTGDP 391 >3MY7-A nrPDB Length = 452 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 42/176 (23%), Positives = 70/176 (39%), Gaps = 3/176 (1%) Query: 148 DGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVAS 207 D N T T EP+G+ I+P P I+K +L N ++ P + + A Sbjct: 92 DDNLGTMTIAEPVGIICGIVPTTNPTSTAIFKSLISLKTRNGIIFSPHPRAKNSTNDAAK 151 Query: 208 LIKEAGFPPGVVNIVPGYGPTAGAAISSH-MDIDKVAFTGSTEVGKLIKEAAGKSNLKRV 266 L+ +A G + G+ +S+ M D +A +T ++K A S+ K Sbjct: 152 LVLDAAVAAGAPKDIIGWIDQPSVELSNALMKHDDIALILATGGPGMVK--AAYSSGKPA 209 Query: 267 TLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRR 322 G P ++ AD+ AV + G C + + V + +YDE R Sbjct: 210 IGVGAGNVPVVIDETADIKRAVASVLMSKTFDNGVVCASEQAVIVVDEVYDEVKER 265 >1EZ0-A nrPDB Length = 510 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 91/392 (23%), Positives = 147/392 (37%), Gaps = 52/392 (13%) Query: 77 WRTMDASERGRLLYKLA--------DLIERDRLLLATMESMNGGKLYSNA-YLNDLAGCI 127 +R ++ S+R LL +A D+I R L A E G++ A L A + Sbjct: 46 FRRLNNSKRASLLRTIASELEARSDDIIARAHLETALPEVRLTGEIARTANQLRLFADVV 105 Query: 128 KTLRYCAGWADKIQGRTIPIDGNFFTYTRHE----PIGVCGQIIPWNFPLVMLIW--KIG 181 + Y D P+ R + P+ V G NFPL Sbjct: 106 NSGSYHQAILDTPNPTRAPLPKP--DIRRQQIALGPVAVFGA---SNFPLAFSAAGGDTA 160 Query: 182 PALSCGNTVVVKPAEQTPLTALHVASLIKEA----GFPPGVVNIVPGYGPTAGAAISSHM 237 AL+ G V+VK P T+ VA I++A P + ++ G G A+ SH Sbjct: 161 SALAAGCPVIVKGHTAHPGTSQIVAECIEQALKQEQLPQAIFTLLQGNQRALGQALVSHP 220 Query: 238 DIDKVAFTGSTEVGK-LIKEAAGKSNLKRVTLELGGKSPCIVL-----ADADL-DNAVEF 290 +I V FTGS G+ L A + ELG +P + A ADL D V Sbjct: 221 EIKAVGFTGSVGGGRALFNLAHERPEPIPFYGELGAINPTFIFPSAMRAKADLADQFVAS 280 Query: 291 AHHGVFYHQGQCCIAASRIFVEESIYDE-FVRRSVERAKKYILGNPLTPGVTQGPQIDKE 349 G GQ C +F + + F+ + ++ LTPG+ ++ Sbjct: 281 MTMGC----GQFCTKPGVVFALNTPETQAFIETAQSLIRQQSPSTLLTPGI-------RD 329 Query: 350 QYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIA---KEEIFGPVQ 406 Y ++ G +G + + V +F ++ R +EEIFGP Sbjct: 330 SYQS--QVVSRGSDDGIDVTFSQA----ESPCVASALFVTSSENWRKHPAWEEEIFGPQS 383 Query: 407 QIMKFKSLDDVIKRANNTFYGLSAGVFTKDID 438 I+ +++ D++ + L+A + + D Sbjct: 384 LIVVCENVADMLSLSEMLAGSLTATIHATEED 415 >5J7I-A nrPDB Length = 488 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 39/167 (23%), Positives = 67/167 (40%), Gaps = 9/167 (5%) Query: 158 EPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKE----AG 213 +P+G+ IIP P +I+K A+ N +V P A +++E AG Sbjct: 129 QPVGIVAGIIPSTNPTSTVIFKALIAVKARNAIVFSPHPSAAKCTAEAARIMQEAAERAG 188 Query: 214 FPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGK 273 P G+++ + A + H D + TG + K A S+ K G Sbjct: 189 APKGLISCITQPTMAATNELMKHKLTDVILATGGPGLVK-----AAYSSGKPAYGVGPGN 243 Query: 274 SPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFV 320 P + A++ AV+ + G C + + V+ESI ++ V Sbjct: 244 VPVYIHESANIAKAVQLIIQSKTFDYGTICASEQALLVDESIKEKVV 290 >5JFN-A nrPDB Length = 524 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 59/283 (20%), Positives = 108/283 (38%), Gaps = 31/283 (10%) Query: 150 NFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLI 209 N T + P GV G I P P ++ L+ GN+VV P + +L + LI Sbjct: 178 NGLTLVEYSPFGVIGAITPTTNPTETIVCNSIGMLAAGNSVVFSPHPRARQVSLLLVRLI 237 Query: 210 KEA----GFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKR 265 + G P +V V A+ +H + + TG + K + S K+ Sbjct: 238 NQKLAALGAPENLVVTVEKPSIENTNAMMAHPKVRMLVATGGPAIVKAV-----LSTGKK 292 Query: 266 VTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVE 325 G P +V A+++ A +G + +A I I D ++ +++ Sbjct: 293 AIGAGAGNPPVVVDETANIEKAACDIVNGCSFDNNLPXVAEKEIIAVAQIAD-YLIFNLK 351 Query: 326 RAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGG--GPW--GNKGYF 381 + Y + +P ++ DL+ + K G + +C G W G Sbjct: 352 KNGAYEIKDPAV-------------LQQLQDLVLTAKG-GPQTKCVGKSAVWLLSQIGIS 397 Query: 382 VQPT---VFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRA 421 V + + V E +EE+ P+ +++ +++DD I A Sbjct: 398 VDASIKIILMEVPREHPFVQEELMMPILPLVRVETVDDAIDLA 440 >3K9D-A nrPDB Length = 464 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 48/211 (22%), Positives = 82/211 (38%), Gaps = 17/211 (8%) Query: 159 PIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKE----AGF 214 P+GV +IP P +I+K ++ GN++V P L +I E AG Sbjct: 108 PLGVVAGLIPSTNPTSTVIYKTLISIKAGNSIVFSPHPNALKAILETVRIISEAAEKAGC 167 Query: 215 PPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKS 274 P G ++ + + H D + TG G + +AA S + + G Sbjct: 168 PKGAISCMTVPTIQGTDQLMKHKDTAVILATG----GSAMVKAAYSSGTPAIGVG-PGNG 222 Query: 275 PCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVE----ESIYDEFVRRS---VERA 327 P + A++ AV+ + G C + + VE E++ EF ++ + A Sbjct: 223 PAFIERSANIPRAVKHILDSKTFDNGTICASEQSVVVERVNKEAVIAEFRKQGAHFLSDA 282 Query: 328 KKYILGN-PLTPGVTQGPQIDKEQYDKILDL 357 + LG L P + P I + I +L Sbjct: 283 EAVQLGKFILRPNGSMNPAIVGKSVQHIANL 313 >2DQ3-A nrPDB Length = 425 Score = 32.7 bits (73), Expect = 0.37, Method: Compositional matrix adjust. Identities = 23/77 (29%), Positives = 31/77 (40%), Gaps = 13/77 (16%) Query: 194 PAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGA------AISSHMDIDKVAF--- 244 P + PLT L+ ++KE P + P Y AGA I DKV Sbjct: 230 PTAEVPLTNLYREEILKEENLPIYLTAYTPCYRREAGAYGKDIRGIIRQHQFDKVELVKI 289 Query: 245 ----TGSTEVGKLIKEA 257 T E+ KL+K+A Sbjct: 290 VHPDTSYDELEKLVKDA 306 >6MPQ-A nrPDB Length = 245 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 19/71 (26%), Positives = 33/71 (46%), Gaps = 4/71 (5%) Query: 81 DASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI 140 D RL +KL E ++LL ++ +NG K+Y+ + G + + GW ++ Sbjct: 154 DDLAHNRLPFKLETQEEVKKMLL--IKEVNGSKIYAKSGWG--MGVTPQVGWLTGWVEQA 209 Query: 141 QGRTIPIDGNF 151 G+ IP N Sbjct: 210 NGKKIPFSLNL 220 >5IJA-A nrPDB Length = 148 Score = 30.4 bits (67), Expect = 1.7, Method: Composition-based stats. Identities = 20/71 (28%), Positives = 35/71 (49%), Gaps = 6/71 (8%) Query: 380 YFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDK 439 +F +F + E+R A G + + +LD+ +KRA F G+ A K+ID Sbjct: 71 HFSGEEIFEKLKAEIRSA--HFMGAIDGLKLLMALDERLKRAEIHFIGIVA----KEIDL 124 Query: 440 AITISSALQAG 450 + +S ++AG Sbjct: 125 GMELSDEVKAG 135 >6GAW-AL nrPDB Length = 139 Score = 30.4 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 17/55 (30%), Positives = 27/55 (49%), Gaps = 6/55 (10%) Query: 176 LIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAG 230 L+ +G +L+CG +V +P P+ L+ + PPG + GPTAG Sbjct: 6 LLRGLGTSLNCGLALVPRPWATRPMATLNQMHRLGPPKHPPGKM------GPTAG 54 >4UWM-A nrPDB Length = 378 Score = 29.3 bits (64), Expect = 4.3, Method: Compositional matrix adjust. Identities = 23/77 (29%), Positives = 32/77 (41%), Gaps = 11/77 (14%) Query: 374 PWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLD---DVIKRA--------N 422 PWG K + T FS + MR+A E F PV +L +V A + Sbjct: 190 PWGGKAPEIAVTGFSYNSPSMRLAGERNFKPVSIFSGLDALKRHWEVYSEAAIEAGHTPD 249 Query: 423 NTFYGLSAGVFTKDIDK 439 + + +S VF D DK Sbjct: 250 RSRHAVSHTVFCADTDK 266 >5ZLU-EE nrPDB Length = 497 Score = 28.9 bits (63), Expect = 5.2, Method: Compositional matrix adjust. Identities = 21/56 (37%), Positives = 31/56 (55%), Gaps = 6/56 (10%) Query: 237 MDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAH 292 +DID++ +G + AGKS+L +V L G+ IVLA+A L +FAH Sbjct: 20 LDIDELEIHSYDRIGLVGDNGAGKSSLLKV---LNGE---IVLAEATLQRFGDFAH 69 >2YVA-A nrPDB Length = 196 Score = 28.9 bits (63), Expect = 5.3, Method: Compositional matrix adjust. Identities = 17/61 (27%), Positives = 25/61 (40%) Query: 7 PDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKA 66 P LP + + N+ HD V K+ A + L G+ D+ KAV+A Sbjct: 72 PSLPAIALNTDNVVLTAIANDRLHDEVYAKQVRALGHAGDVLLAISTRGNSRDIVKAVEA 131 Query: 67 A 67 A Sbjct: 132 A 132 >4N8G-A nrPDB Length = 352 Score = 28.9 bits (63), Expect = 5.3, Method: Compositional matrix adjust. Identities = 18/54 (33%), Positives = 28/54 (51%), Gaps = 6/54 (11%) Query: 13 LTDLKIQYTKIFI--NNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAV 64 LT +QY+ F+ N EW+D +S + A +E E ++EDV+K V Sbjct: 233 LTLANVQYSDQFLIANGEWYDDLSEENRQAIEAAVQE----ASELNREDVEKRV 282 >3KA0-A nrPDB Length = 320 Score = 28.9 bits (63), Expect = 5.3, Method: Compositional matrix adjust. Identities = 22/85 (25%), Positives = 37/85 (43%), Gaps = 9/85 (10%) Query: 33 VSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKL 92 ++GK +FN T+E+ D + V+ +A Q R +D E Sbjct: 28 INGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYE-------- 79 Query: 93 ADLIERDRLLLATMESMNGGKLYSN 117 +L + LL ME ++GG+L+S Sbjct: 80 -NLYAGRKCLLIVMECLDGGELFSR 103 >3M42-A nrPDB Length = 299 Score = 28.9 bits (63), Expect = 6.1, Method: Compositional matrix adjust. Identities = 22/85 (25%), Positives = 37/85 (43%), Gaps = 9/85 (10%) Query: 33 VSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKL 92 ++GK +FN T+E+ D + V+ +A Q R +D E Sbjct: 30 INGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYE-------- 81 Query: 93 ADLIERDRLLLATMESMNGGKLYSN 117 +L + LL ME ++GG+L+S Sbjct: 82 -NLYAGRKCLLIVMECLDGGELFSR 105 >2OZA-A nrPDB Length = 356 Score = 28.9 bits (63), Expect = 6.2, Method: Compositional matrix adjust. Identities = 22/85 (25%), Positives = 37/85 (43%), Gaps = 9/85 (10%) Query: 33 VSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKL 92 ++GK +FN T+E+ D + V+ +A Q R +D E Sbjct: 30 INGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYE-------- 81 Query: 93 ADLIERDRLLLATMESMNGGKLYSN 117 +L + LL ME ++GG+L+S Sbjct: 82 -NLYAGRKCLLIVMECLDGGELFSR 105 >2DLC-X nrPDB Length = 394 Score = 28.5 bits (62), Expect = 6.7, Method: Compositional matrix adjust. Identities = 15/50 (30%), Positives = 25/50 (50%) Query: 328 KKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGN 377 K+ L NP+ PG+ QG ++ + +DL+E K+ K+ GN Sbjct: 210 KRAHLMNPMVPGLAQGGKMSASDPNSKIDLLEEPKQVKKKINSAFCSPGN 259 >1NY3-A nrPDB Length = 400 Score = 28.5 bits (62), Expect = 6.9, Method: Compositional matrix adjust. Identities = 22/84 (26%), Positives = 37/84 (44%), Gaps = 9/84 (10%) Query: 33 VSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKL 92 ++GK +FN T+E+ D + V+ +A Q R +D E Sbjct: 74 INGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYE-------- 125 Query: 93 ADLIERDRLLLATMESMNGGKLYS 116 +L + LL ME ++GG+L+S Sbjct: 126 -NLYAGRKCLLIVMECLDGGELFS 148 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5AC2-A nrPDB 757 0.0 5AC0-A nrPDB 749 0.0 1O9J-A nrPDB 716 0.0 4X2Q-A nrPDB 706 0.0 5FHZ-A nrPDB 700 0.0 5L13-A nrPDB 695 0.0 1AG8-A nrPDB 688 0.0 5GT6-A nrPDB 628 e-180 4PXL-B nrPDB 624 e-179 4V3F-A nrPDB 611 e-175 4PZ2-A nrPDB 611 e-175 4CAZ-A nrPDB 600 e-172 4O6R-A nrPDB 594 e-170 3RHO-A nrPDB 589 e-168 3IWK-A nrPDB 580 e-166 3IWJ-A nrPDB 579 e-165 6B4R-B nrPDB 579 e-165 4MPY-A nrPDB 572 e-163 4GO4-A nrPDB 571 e-163 5IUV-A nrPDB 571 e-163 3JZ4-A nrPDB 570 e-163 6QAO-A nrPDB 569 e-162 1BPW-A nrPDB 568 e-162 4I8P-A nrPDB 564 e-161 4QYJ-A nrPDB 562 e-160 4I8Q-A nrPDB 560 e-160 4O5H-A nrPDB 556 e-158 2D4E-A nrPDB 554 e-158 3R31-A nrPDB 553 e-158 4V6H-A nrPDB 538 e-153 5KLK-A nrPDB 529 e-150 5J77-A nrPDB 527 e-150 3EK1-A nrPDB 527 e-150 1WNB-A nrPDB 527 e-150 6C43-A nrPDB 522 e-148 3TY7-A nrPDB 520 e-148 4LIH-A nrPDB 519 e-147 3I44-A nrPDB 515 e-146 4U3W-A nrPDB 513 e-146 4F3X-A nrPDB 509 e-144 3U4J-A nrPDB 508 e-144 3K2W-A nrPDB 508 e-144 2HG2-A nrPDB 508 e-144 5EUY-A nrPDB 505 e-143 1T90-A nrPDB 498 e-141 3B4W-A nrPDB 498 e-141 5X5U-A nrPDB 490 e-139 3QAN-A nrPDB 488 e-138 3RHD-A nrPDB 487 e-138 4JZ6-A nrPDB 485 e-137 4YWE-A nrPDB 484 e-137 3RJL-A nrPDB 484 e-137 5VBF-A nrPDB 483 e-137 3RH9-A nrPDB 483 e-137 2W8P-A nrPDB 482 e-136 2JG7-A nrPDB 479 e-135 5TJR-A nrPDB 476 e-135 4X0T-A nrPDB 469 e-132 2QE0-A nrPDB 466 e-131 4DNG-A nrPDB 465 e-131 5UR2-A nrPDB 463 e-131 3R64-A nrPDB 462 e-130 4ZZ7-A nrPDB 462 e-130 3PRL-A nrPDB 461 e-130 6FK3-A nrPDB 460 e-130 6MVR-A nrPDB 460 e-130 4PXN-A nrPDB 455 e-128 3VZ3-A nrPDB 453 e-127 3VZ0-A nrPDB 452 e-127 3ROS-A nrPDB 451 e-127 4OGD-A nrPDB 451 e-127 3EFV-A nrPDB 445 e-125 2J5N-A nrPDB 440 e-124 5KF0-A nrPDB 439 e-123 5N5S-A nrPDB 438 e-123 5JRY-A nrPDB 434 e-122 4E4G-A nrPDB 431 e-121 5U0M-A nrPDB 425 e-119 5J6B-A nrPDB 423 e-119 1UXV-A nrPDB 416 e-116 3SZA-A nrPDB 413 e-115 6DBB-A nrPDB 404 e-113 4KNA-A nrPDB 404 e-113 4LGZ-A nrPDB 403 e-113 3V9H-A nrPDB 403 e-112 1AD3-A nrPDB 402 e-112 3JU8-A nrPDB 396 e-110 4I3V-A nrPDB 394 e-110 4QGK-A nrPDB 376 e-104 4OE4-A nrPDB 368 e-102 5UCD-A nrPDB 357 5e-99 4H7N-A nrPDB 349 1e-96 4IDS-A nrPDB 330 1e-90 5NNO-A nrPDB 311 6e-85 2Y53-A nrPDB 253 1e-67 3V4C-A nrPDB 247 1e-65 5DBV-A nrPDB 229 2e-60 6D97-A nrPDB 219 2e-57 1EZ0-A nrPDB 208 3e-54 5JFN-A nrPDB 193 1e-49 3MY7-A nrPDB 178 5e-45 5J7I-A nrPDB 167 1e-41 5UJU-A nrPDB 147 1e-35 Sequences not found previously or not previously below threshold: 3K9D-A nrPDB 149 4e-36 1O20-A nrPDB 112 3e-25 4GHK-A nrPDB 98 1e-20 1VLU-A nrPDB 76 4e-14 2H5G-A nrPDB 74 2e-13 4JBE-A nrPDB 71 1e-12 3AGK-A nrPDB 33 0.26 1PDZ-A nrPDB 32 0.61 4U83-A nrPDB 31 0.87 6AHD-9 nrPDB 31 1.1 4N4Q-A nrPDB 31 1.3 3DOD-A nrPDB 31 1.4 4Q1V-A nrPDB 31 1.4 3Q09-A nrPDB 31 1.6 6M99-B nrPDB 30 2.0 5IPN-F nrPDB 30 2.3 1R6V-A nrPDB 30 2.7 4X6G-A nrPDB 30 2.9 1J3N-A nrPDB 30 2.9 4AC0-A nrPDB 30 3.2 3A2Q-A nrPDB 30 3.2 3LOO-A nrPDB 29 3.3 2CUN-A nrPDB 29 3.6 1VLC-A nrPDB 29 3.7 3UF0-A nrPDB 29 3.9 2IPH-A nrPDB 29 5.1 1NNE-A nrPDB 29 5.1 1EWR-A nrPDB 29 5.3 1QNN-A nrPDB 29 5.8 2DG6-A nrPDB 28 7.5 4WJB-A nrPDB 28 8.0 3WGL-A nrPDB 28 10.0 >5AC2-A nrPDB Length = 501 Score = 757 bits (1955), Expect = 0.0, Method: Composition-based stats. Identities = 501/501 (100%), Positives = 501/501 (100%) Query: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV Sbjct: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60 Query: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL Sbjct: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120 Query: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI Sbjct: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180 Query: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID Sbjct: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240 Query: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG 300 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG Sbjct: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG 300 Query: 301 QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES 360 QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES Sbjct: 301 QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES 360 Query: 361 GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR 420 GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR Sbjct: 361 GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR 420 Query: 421 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE 480 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE Sbjct: 421 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE 480 Query: 481 YGFHEYTEVKTVTVKISQKNS 501 YGFHEYTEVKTVTVKISQKNS Sbjct: 481 YGFHEYTEVKTVTVKISQKNS 501 >5AC0-A nrPDB Length = 501 Score = 749 bits (1935), Expect = 0.0, Method: Composition-based stats. Identities = 459/501 (91%), Positives = 485/501 (96%) Query: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60 MSSS PD+P LT+L+ +YTKIFINNEWH SVSGKKFPVFNPATEE+LC+VEEGDKEDV Sbjct: 1 MSSSAMPDVPAPLTNLQFKYTKIFINNEWHSSVSGKKFPVFNPATEEKLCEVEEGDKEDV 60 Query: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120 DKAVKAARQAFQIGSPWRTMDASERGRLL KLADLIERDRLLLATME+MNGGKL+SNAYL Sbjct: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLIERDRLLLATMEAMNGGKLFSNAYL 120 Query: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180 DL GCIKTLRYCAGWADKIQGRTIP+DGNFFTYTR EP+GVCGQIIPWNFPL+M +WKI Sbjct: 121 MDLGGCIKTLRYCAGWADKIQGRTIPMDGNFFTYTRSEPVGVCGQIIPWNFPLLMFLWKI 180 Query: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240 GPALSCGNTVVVKPAEQTPLTALH+ SLIKEAGFPPGVVNIVPGYGPTAGAAISSHMD+D Sbjct: 181 GPALSCGNTVVVKPAEQTPLTALHMGSLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVD 240 Query: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG 300 KVAFTGSTEVGKLIKEAAGKSNLKRV+LELGGKSPCIV ADADLDNAVEFAH GVFYHQG Sbjct: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVSLELGGKSPCIVFADADLDNAVEFAHQGVFYHQG 300 Query: 301 QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES 360 QCCIAASR+FVEESIYDEFVRRSVERAKKY+LGNPLTPGV+QGPQIDKEQY+KILDLIES Sbjct: 301 QCCIAASRLFVEESIYDEFVRRSVERAKKYVLGNPLTPGVSQGPQIDKEQYEKILDLIES 360 Query: 361 GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR 420 GKKEGAKLECGGGPWGNKGYF+QPTVFS+VTD+MRIAKEEIFGPVQQIMKFKSLDDVIKR Sbjct: 361 GKKEGAKLECGGGPWGNKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQIMKFKSLDDVIKR 420 Query: 421 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE 480 ANNTFYGLSAG+FT DIDKAIT+SSALQ+GTVWVNCY VVSAQCPFGGFKMSGNGRELGE Sbjct: 421 ANNTFYGLSAGIFTNDIDKAITVSSALQSGTVWVNCYSVVSAQCPFGGFKMSGNGRELGE 480 Query: 481 YGFHEYTEVKTVTVKISQKNS 501 YGFHEYTEVKTVT+KISQKNS Sbjct: 481 YGFHEYTEVKTVTIKISQKNS 501 >1O9J-A nrPDB Length = 501 Score = 716 bits (1849), Expect = 0.0, Method: Composition-based stats. Identities = 416/501 (83%), Positives = 467/501 (93%) Query: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60 MSSSG PDLP LT++KIQ+TK+FINNEWH+SVSGK FPVFNPATEE++C+VEE DKEDV Sbjct: 1 MSSSGMPDLPAPLTNIKIQHTKLFINNEWHESVSGKTFPVFNPATEEKICEVEEADKEDV 60 Query: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120 DKAVKAAR+AFQ+GSPWRTMDASERG+L+YKLADLIERDRLLLAT+ES+N GK++++AYL Sbjct: 61 DKAVKAAREAFQMGSPWRTMDASERGQLIYKLADLIERDRLLLATLESINAGKVFASAYL 120 Query: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180 DL CIK LRYCAGWADKIQGRTIP+DG FF+YTRHEPIGVCG I PWN P+++L KI Sbjct: 121 MDLDYCIKALRYCAGWADKIQGRTIPVDGEFFSYTRHEPIGVCGLIFPWNAPMILLACKI 180 Query: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240 GPAL CGNTV+VKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMD+D Sbjct: 181 GPALCCGNTVIVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVD 240 Query: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG 300 KVAFTGSTEVGK+I+EAA KSNLKRVTLELG K+PCIV ADADLD+AVEFAH GVF +QG Sbjct: 241 KVAFTGSTEVGKMIQEAAAKSNLKRVTLELGAKNPCIVFADADLDSAVEFAHQGVFTNQG 300 Query: 301 QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES 360 Q CIAAS++FVEE+IYDEFV+RSVERAKKY+ GNPLTPGV GPQI+K Q++KI++LIES Sbjct: 301 QSCIAASKLFVEEAIYDEFVQRSVERAKKYVFGNPLTPGVNHGPQINKAQHNKIMELIES 360 Query: 361 GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR 420 GKKEGAKLECGGGPWGNKGYF+QPTVFSNVTD+MRIAKEEIFGPVQQIMKFKSLD+VIKR Sbjct: 361 GKKEGAKLECGGGPWGNKGYFIQPTVFSNVTDDMRIAKEEIFGPVQQIMKFKSLDEVIKR 420 Query: 421 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE 480 ANNT+YGL AGVFTKD+DKA+T+SSALQAGTVWVNCY SAQ P GGFKMSG+GRE+GE Sbjct: 421 ANNTYYGLVAGVFTKDLDKAVTVSSALQAGTVWVNCYLAASAQSPAGGFKMSGHGREMGE 480 Query: 481 YGFHEYTEVKTVTVKISQKNS 501 YG HEYTEVKTVT+KIS+KNS Sbjct: 481 YGIHEYTEVKTVTMKISEKNS 501 >4X2Q-A nrPDB Length = 504 Score = 706 bits (1824), Expect = 0.0, Method: Composition-based stats. Identities = 360/492 (73%), Positives = 430/492 (87%) Query: 10 PVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQ 69 P +L+I+YTKIFINNEW +S SG+ FPV+NPAT E++C+V+E DK D+DKAV+AAR Sbjct: 13 PSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARL 72 Query: 70 AFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKT 129 AF +GS WR MDASERGRLL KLADL+ERDR +LATMES+NGGK + A+ DL G IKT Sbjct: 73 AFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKT 132 Query: 130 LRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNT 189 RY AGWADKI G TIP+DG++FT+TRHEPIGVCGQIIPWNFPL+M WKI PAL CGNT Sbjct: 133 FRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNT 192 Query: 190 VVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTE 249 VV+KPAEQTPL+AL++ +LIKEAGFPPGV+NI+PGYGPTAGAAI+SH+ IDK+AFTGSTE Sbjct: 193 VVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTE 252 Query: 250 VGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRI 309 VGKLI+EAAG+SNLKRVTLELGGKSP I+ ADADLD AVE AH GVF++QGQCC A SRI Sbjct: 253 VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRI 312 Query: 310 FVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLE 369 FVEESIY+EFVRRSVERAK+ ++G+P P QGPQIDK+QY+KIL+LI+SG EGAKLE Sbjct: 313 FVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLE 372 Query: 370 CGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLS 429 CGG G KG+F++PTVFSNVTD+MRIAKEEIFGPVQ+I++FK++D+VI+RANN+ +GL Sbjct: 373 CGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLV 432 Query: 430 AGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEV 489 A VFT DI+KA+T+SSA+QAGTVW+NCY ++AQ PFGGFKMSGNGRE+GE+G EY+EV Sbjct: 433 AAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEV 492 Query: 490 KTVTVKISQKNS 501 KTVTVKI QKNS Sbjct: 493 KTVTVKIPQKNS 504 >5FHZ-A nrPDB Length = 529 Score = 700 bits (1807), Expect = 0.0, Method: Composition-based stats. Identities = 350/494 (70%), Positives = 419/494 (84%) Query: 7 PDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKA 66 P LP + +L++++TKIFINNEWH+S SGKKF NP+T E++C+VEEGDK DVDKAV+A Sbjct: 35 PALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEA 94 Query: 67 ARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGC 126 A+ AFQ GSPWR +DA RGRLL++LADL+ERDR LA +E+M+ GK + +A+ DL GC Sbjct: 95 AQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGC 154 Query: 127 IKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSC 186 I+TLRY AGWADKIQG+TIP D N +TRHEPIGVCG I PWNFPL+ML+WK+ PAL C Sbjct: 155 IRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCC 214 Query: 187 GNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTG 246 GNT+V+KPAEQTPLTAL++ SLIKEAGFPPGVVNIVPG+GPT GAAISSH I+K+AFTG Sbjct: 215 GNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTG 274 Query: 247 STEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAA 306 STEVGKL+KEAA +SNLKRVTLELGGK+PCIV ADADLD AVE AH GVF++QGQCC AA Sbjct: 275 STEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAA 334 Query: 307 SRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGA 366 SR+FVEE +Y EFVRRSVE AKK +G+P QGPQID++Q+DKIL+LIESGKKEGA Sbjct: 335 SRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGA 394 Query: 367 KLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFY 426 KLECGG +KG F++PTVFS VTD MRIAKEEIFGPVQ I+KFKS+++VIKRAN+T Y Sbjct: 395 KLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDY 454 Query: 427 GLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEY 486 GL+A VFTK++DKA+ ++SAL++GTVW+NCY + AQ PFGGFKMSGNGRELGEY EY Sbjct: 455 GLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEY 514 Query: 487 TEVKTVTVKISQKN 500 TEVKTVT+K+ KN Sbjct: 515 TEVKTVTIKLGDKN 528 >5L13-A nrPDB Length = 517 Score = 695 bits (1794), Expect = 0.0, Method: Composition-based stats. Identities = 341/501 (68%), Positives = 408/501 (81%) Query: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60 +S++ T +P ++ +IFINNEWHD+VS K FP NP+T E +CQV EGDKEDV Sbjct: 17 LSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDV 76 Query: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120 DKAVKAAR AFQ+GSPWR MDAS RGRLL +LADLIERDR LA +E+++ GK Y +YL Sbjct: 77 DKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYL 136 Query: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180 DL +K LRY AGWADK G+TIPIDG+FF+YTRHEP+GVCGQIIPWNFPL+M WK+ Sbjct: 137 VDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKL 196 Query: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240 GPAL+ GN VV+K AEQTPLTAL+VA+LIKEAGFPPGVVNIVPG+GPTAGAAI+SH D+D Sbjct: 197 GPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVD 256 Query: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG 300 KVAFTGSTE+G++I+ AAG SNLKRVTLELGGKSP I+++DAD+D AVE AH +F++QG Sbjct: 257 KVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQG 316 Query: 301 QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES 360 QCC A SR FV+E IYDEFV RSV RAK ++GNP QGPQ+D+ Q+ KIL I + Sbjct: 317 QCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINT 376 Query: 361 GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR 420 GK+EGAKL CGGG ++GYF+QPTVF +V D M IAKEEIFGPV QI+KFK++++V+ R Sbjct: 377 GKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGR 436 Query: 421 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE 480 ANN+ YGL+A VFTKD+DKA +S ALQAGTVWVNCY V AQ PFGG+KMSG+GRELGE Sbjct: 437 ANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGE 496 Query: 481 YGFHEYTEVKTVTVKISQKNS 501 YG YTEVKTVTVK+ QKNS Sbjct: 497 YGLQAYTEVKTVTVKVPQKNS 517 >1AG8-A nrPDB Length = 499 Score = 688 bits (1776), Expect = 0.0, Method: Composition-based stats. Identities = 334/499 (66%), Positives = 405/499 (81%) Query: 3 SSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDK 62 S+ T +P ++ Y +IFINNEWHD+VS K FP NP+T + +C V EGDK DVD+ Sbjct: 1 SAATQAVPTPNQQPEVLYNQIFINNEWHDAVSKKTFPTVNPSTGDVICHVAEGDKADVDR 60 Query: 63 AVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLND 122 AVKAAR AFQ+GSPWR MDASERGRLL +LADLIERDR LA +E+++ GK Y +YL D Sbjct: 61 AVKAARAAFQLGSPWRRMDASERGRLLNRLADLIERDRTYLAALETLDNGKPYIISYLVD 120 Query: 123 LAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGP 182 L +K LRY AGWADK G+TIPIDG++F+YTRHEP+GVCGQIIPWNFPL+M WK+GP Sbjct: 121 LDMVLKCLRYYAGWADKYHGKTIPIDGDYFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGP 180 Query: 183 ALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKV 242 AL+ GN VV+K AEQTPLTAL+VA+LIKEAGFPPGVVN++PG+GPTAGAAI+SH D+DKV Sbjct: 181 ALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNVIPGFGPTAGAAIASHEDVDKV 240 Query: 243 AFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQC 302 AFTGSTEVG LI+ AAGKSNLKRVTLE+GGKSP I+++DAD+D AVE AH +F++QGQC Sbjct: 241 AFTGSTEVGHLIQVAAGKSNLKRVTLEIGGKSPNIIMSDADMDWAVEQAHFALFFNQGQC 300 Query: 303 CIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGK 362 C A SR FV+E IY EFV RSV RAK ++GNP QGPQ+D+ Q+ K+L I+SGK Sbjct: 301 CCAGSRTFVQEDIYAEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKKVLGYIKSGK 360 Query: 363 KEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRAN 422 +EG KL CGGG ++GYF+QPTVF ++ D M IAKEEIFGPV QI+KFKS+++V+ RAN Sbjct: 361 EEGLKLLCGGGAAADRGYFIQPTVFGDLQDGMTIAKEEIFGPVMQILKFKSMEEVVGRAN 420 Query: 423 NTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYG 482 N+ YGL+A VFTKD+DKA +S ALQAGTVWVNCY V AQ PFGG+K+SG+GRELGEYG Sbjct: 421 NSKYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKLSGSGRELGEYG 480 Query: 483 FHEYTEVKTVTVKISQKNS 501 YTEVKTVTV++ QKNS Sbjct: 481 LQAYTEVKTVTVRVPQKNS 499 >5GT6-A nrPDB Length = 508 Score = 628 bits (1619), Expect = e-180, Method: Composition-based stats. Identities = 258/497 (51%), Positives = 338/497 (68%), Gaps = 11/497 (2%) Query: 10 PVLLTDLKI---------QYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60 P+L T++++ + K+FIN E+ ++ GK F +NPATE+ L V E +ED+ Sbjct: 14 PMLKTNIELKPKVEAFLNEEIKMFINGEFVSAIGGKTFETYNPATEDVLAVVCEAQEEDI 73 Query: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120 D AVKAAR AF+ G PW M +ER L+YKLADLIE R LA +E+++ GK Y A Sbjct: 74 DAAVKAARSAFESG-PWAEMTTAERAHLIYKLADLIEEHREELAQLEALDNGKPYQVALD 132 Query: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180 +D++ ++ RY AGW KI G+TIPI ++ YTRHEP+GV GQIIPWNFPLVM WK+ Sbjct: 133 DDISATVENYRYYAGWTTKIIGQTIPISKDYLNYTRHEPVGVVGQIIPWNFPLVMSSWKM 192 Query: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240 G AL+ G T+V+KPAEQTPL+ L+ A L KEAGFP GVVN VPG+GP AGAAI +H DID Sbjct: 193 GAALATGCTIVLKPAEQTPLSLLYAAKLFKEAGFPNGVVNFVPGFGPEAGAAIVNHHDID 252 Query: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG 300 KVAFTGST GK I + + +K VTLELGGKSP I+L DADL+ A+ A G+ Y+ G Sbjct: 253 KVAFTGSTVTGKYIMRQSAEM-IKHVTLELGGKSPNIILEDADLEEAINGAFQGIMYNHG 311 Query: 301 QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES 360 Q C A SR+FV Y+ V V+ A LG + GP + K+Q +++L+ IE Sbjct: 312 QNCSAGSRVFVHRKHYETVVDALVKMANNVKLGAGMEKETEMGPLVSKKQQERVLNYIEQ 371 Query: 361 GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR 420 GKKEGA + GG KGYFV+PTVF++VTD+M I KEEIFGPV ++ F S ++VI+R Sbjct: 372 GKKEGATVAAGGERALEKGYFVKPTVFTDVTDDMTIVKEEIFGPVVVVLPFDSTEEVIER 431 Query: 421 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE 480 ANN+ YGL+AGV+T++I +++ L+AGTVW+N Y + +A PFGG+K SG GRELG Sbjct: 432 ANNSSYGLAAGVWTQNIKTGHQVANKLKAGTVWINDYNLENAAAPFGGYKQSGIGRELGS 491 Query: 481 YGFHEYTEVKTVTVKIS 497 Y YTEVK+V V I Sbjct: 492 YALDNYTEVKSVWVNIK 508 >4PXL-B nrPDB Length = 517 Score = 624 bits (1611), Expect = e-179, Method: Composition-based stats. Identities = 252/495 (50%), Positives = 359/495 (72%), Gaps = 5/495 (1%) Query: 2 SSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVD 61 SS G+ ++P +++++TK+FI+ ++ D+VSGK F +P T E + + EGDK DVD Sbjct: 22 SSKGSFEVP----KVEVRFTKLFIDGKFVDAVSGKTFETRDPRTGEVIASIAEGDKADVD 77 Query: 62 KAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLN 121 AVKAAR+AF G PW M ERGR+L++ ADLI+ LA +++++ GKL++ Sbjct: 78 LAVKAAREAFDNG-PWPRMTGYERGRILHRFADLIDEHVEELAALDTVDAGKLFAVGKAR 136 Query: 122 DLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIG 181 D+ G LRY AG ADK+ G T+ + YT EP+GV G I+PWN+P M +K+G Sbjct: 137 DIPGAAHLLRYYAGAADKVHGATLKMAQRMHGYTLKEPVGVVGHIVPWNYPTTMFFFKVG 196 Query: 182 PALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDK 241 PAL+ G VVVKPAEQTPL+AL A L +EAG P GV+N+VPG+GPTAGAA+++HMD+DK Sbjct: 197 PALAAGCAVVVKPAEQTPLSALFYAHLAREAGVPAGVLNVVPGFGPTAGAAVAAHMDVDK 256 Query: 242 VAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQ 301 V+FTGSTEVG+L+ AA +SNLK V+LELGGKSP IV DADLD AV + + ++G+ Sbjct: 257 VSFTGSTEVGRLVMRAAAESNLKPVSLELGGKSPVIVFDDADLDMAVNLVNFATYTNKGE 316 Query: 302 CCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESG 361 C+A +RI+V+E IYDEFV+++ E A K ++G+P P V+QGPQ+DK+QY+K+L I+ G Sbjct: 317 ICVAGTRIYVQEGIYDEFVKKAAELASKSVVGDPFNPSVSQGPQVDKDQYEKVLRYIDIG 376 Query: 362 KKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRA 421 K+EGA L GG P G+KGY+++PT+F++V D+M IA++EIFGPV +MKFK++++VI++A Sbjct: 377 KREGATLVTGGKPCGDKGYYIEPTIFTDVKDDMTIAQDEIFGPVMALMKFKTVEEVIQKA 436 Query: 422 NNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEY 481 NNT YGL+AG+ TK+ID A T+S +++AG +W+NCY PFGG+KMSG G+++G Sbjct: 437 NNTRYGLAAGIVTKNIDVANTVSRSIRAGAIWINCYFAFDPDAPFGGYKMSGFGKDMGMD 496 Query: 482 GFHEYTEVKTVTVKI 496 +Y + KTV + Sbjct: 497 ALDKYLQTKTVVTPL 511 >4V3F-A nrPDB Length = 497 Score = 611 bits (1576), Expect = e-175, Method: Composition-based stats. Identities = 201/490 (41%), Positives = 287/490 (58%), Gaps = 11/490 (2%) Query: 17 KIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSP 76 I ++FI+ EW + + + PV NP+TEE + + EDV+ AV AAR+AF+ + Sbjct: 4 PIPARQLFIDGEWREPIKKNRIPVINPSTEEIIGDIPAATAEDVEVAVVAARRAFRRNN- 62 Query: 77 WRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGW 136 W + R L +A I + +E+++ GK + A L D+ Y AG Sbjct: 63 WSATSGAHRATYLRAIAAKITEKKDHFVKLETIDSGKPFDEAVL-DIDDVASCFEYFAGQ 121 Query: 137 ADKIQGR-----TIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVV 191 A+ + G+ T+P++ F ++ +P+GV G I PWN+PL+M WKI PAL+ G T V Sbjct: 122 AEALDGKQKAPVTLPMER-FKSHVLRQPLGVVGLISPWNYPLLMATWKIAPALAAGCTAV 180 Query: 192 VKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVG 251 +KP+E +T L + E G PPGV+NI+ G GP AGA + SH D+DK+AFTGS+ G Sbjct: 181 LKPSELASVTCLEFGEVCNEVGLPPGVLNILTGLGPDAGAPLVSHPDVDKIAFTGSSATG 240 Query: 252 KLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFV 311 + +A + +K VTLELGGKSP +V D D+D VE+ G F+ GQ C A SR+ V Sbjct: 241 SKVMASAAQL-VKPVTLELGGKSPIVVFEDVDIDKVVEWTIFGCFWTNGQICSATSRLLV 299 Query: 312 EESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECG 371 ESI EFV + V+ K + +P G GP I K QYDKI+ I + K EGA + G Sbjct: 300 HESIAAEFVDKLVKWTKNIKISDPFEEGCRLGPVISKGQYDKIMKFISTAKSEGATILYG 359 Query: 372 GGPWGN--KGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLS 429 G + KGY+++PT+ ++++ M+I KEE+FGPV + F S D+ I AN+T YGL+ Sbjct: 360 GSRPEHLKKGYYIEPTIVTDISTSMQIWKEEVFGPVLCVKTFSSEDEAIALANDTEYGLA 419 Query: 430 AGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEV 489 A VF+ D+++ I+ AL+ G VWVNC Q P+GG K SG GRELGE+G Y + Sbjct: 420 AAVFSNDLERCERITKALEVGAVWVNCSQPCFVQAPWGGIKRSGFGRELGEWGIQNYLNI 479 Query: 490 KTVTVKISQK 499 K VT IS + Sbjct: 480 KQVTQDISDE 489 >4PZ2-A nrPDB Length = 534 Score = 611 bits (1575), Expect = e-175, Method: Composition-based stats. Identities = 251/486 (51%), Positives = 339/486 (69%), Gaps = 4/486 (0%) Query: 16 LKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGS 75 +I++TK+FIN + D+VSG+ F +P T + V E DKEDVD AV+AAR AF G Sbjct: 46 PEIRFTKLFINGSFVDAVSGRTFDTRDPRTGGVIASVAEADKEDVDLAVRAARAAFDHG- 104 Query: 76 PWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAG 135 W M SERGR++ +LADL+E LA +ES++ GK + D+ +LRY AG Sbjct: 105 EWPRMSGSERGRIMARLADLVEEHAGELAALESLDAGKHPAVTRAVDVGNAAGSLRYFAG 164 Query: 136 WADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPA 195 ADKI G T+ + G F +T EP+GV G IIPWNFP M K+ PAL+ G +VVKPA Sbjct: 165 AADKIHGETLKMPGQFQGHTLREPLGVAGVIIPWNFPSTMFAVKVAPALAAGCALVVKPA 224 Query: 196 EQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIK 255 EQTPL+AL++A L K+AG P GV+N+VPG+GPTAGAA++SHMD+D V+FTGSTEVG+LI Sbjct: 225 EQTPLSALYLAQLAKQAGVPDGVINVVPGFGPTAGAALASHMDVDMVSFTGSTEVGRLIM 284 Query: 256 EAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESI 315 +A+ +SNLK V LELGGKSP IV DADLD AVE A F+++G+ C+AASR++V+E + Sbjct: 285 KASAESNLKPVYLELGGKSPLIVFDDADLDMAVELAVGASFFNKGEACVAASRVYVQERV 344 Query: 316 YDEFVRRSVERAKKYILGNPL-TPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGP 374 YD F R ER + +++G+P P QGPQ+DK QY+++L I+ GK+EGA L GG P Sbjct: 345 YDRFEERLAERMRSWVVGDPFSDPRADQGPQVDKAQYERVLSYIDHGKREGATLLTGGRP 404 Query: 375 W--GNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGV 432 KGY+++PTVF+NV ++M IAKEEIFGPV +MKFK++++ I RAN+T YGL AGV Sbjct: 405 CAPEGKGYYIEPTVFTNVKEDMIIAKEEIFGPVMCLMKFKTVEEAIARANDTRYGLGAGV 464 Query: 433 FTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492 T+D+D A + +++AG VWVNCY + + CPFGG KMSG G++ G + +Y VK+V Sbjct: 465 VTRDLDVANRVVRSVRAGVVWVNCYFAMGSDCPFGGRKMSGFGKDEGMHALDKYLAVKSV 524 Query: 493 TVKISQ 498 + Sbjct: 525 VTPLRA 530 >4CAZ-A nrPDB Length = 490 Score = 600 bits (1547), Expect = e-172, Method: Composition-based stats. Identities = 189/489 (38%), Positives = 281/489 (57%), Gaps = 7/489 (1%) Query: 17 KIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSP 76 + + K++I + ++ SG F NPA E L +V+ +EDV++AV++A + ++ Sbjct: 3 RFEEQKLYIGGRYVEASSGATFETINPANGEVLAKVQRASREDVERAVQSAVEGQKV--- 59 Query: 77 WRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGW 136 W M A +R R+L + D++ LA +E+++ GK + D+ L Y AG Sbjct: 60 WAAMTAMQRSRILRRAVDILRERNDELAALETLDTGKPLAETRSVDIVTGADVLEYYAGL 119 Query: 137 ADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAE 196 I+G IP+ F YTR EP+GV I WN+P+ + +WK PAL+ GN ++ KP+E Sbjct: 120 VPAIEGEQIPLRETSFVYTRREPLGVVAGIGAWNYPVQIALWKSAPALAAGNAMIFKPSE 179 Query: 197 QTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKE 256 TPLTAL +A + EAG P GV N++ G G G ++ H I+K++FTG T GK + Sbjct: 180 VTPLTALKLAEIYTEAGVPDGVFNVLTGSGREVGQWLTEHPLIEKISFTGGTSTGKKVMA 239 Query: 257 AAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY 316 +A S+LK VT+ELGGKSP I+ DADLD A + A F+ GQ C +R+F+ S Sbjct: 240 SASSSSLKEVTMELGGKSPLIIFPDADLDRAADIAVMANFFSSGQVCTNGTRVFIHRSQQ 299 Query: 317 DEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG 376 F + +ER ++ LG+P GP + + +L IESGK + A+L CGG Sbjct: 300 ARFEAKVLERVQRIRLGDPQDENTNFGPLVSFPHMESVLGYIESGKAQKARLLCGGERVT 359 Query: 377 N----KGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGV 432 + KG +V PTVF++ D+M I +EEIFGPV I+ + D+ I+RAN+T YGL+AGV Sbjct: 360 DGAFGKGAYVAPTVFTDCRDDMTIVREEIFGPVMSILVYDDEDEAIRRANDTEYGLAAGV 419 Query: 433 FTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492 T+D+ +A L+AG W+N +G A+ P GG+K SG GRE G YT +K+V Sbjct: 420 VTQDLARAHRAIHRLEAGICWINTWGESPAEMPVGGYKQSGVGRENGLTTLAHYTRIKSV 479 Query: 493 TVKISQKNS 501 V++ S Sbjct: 480 QVELGDYAS 488 >4O6R-A nrPDB Length = 496 Score = 594 bits (1532), Expect = e-170, Method: Composition-based stats. Identities = 207/483 (42%), Positives = 290/483 (60%), Gaps = 8/483 (1%) Query: 21 TKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80 T++FI+ + D+V V NP + ++ DVD AV AA +AF W M Sbjct: 11 TQLFIDGRFVDAVDRGTIDVLNPHDGSVITKIAAATAADVDLAVDAATRAF---PAWSAM 67 Query: 81 DASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI 140 A+ERGRLL +LAD IE + LA +ES++ G ++ D+ RY G ADK+ Sbjct: 68 PAAERGRLLLRLADAIEANTEALAQLESLDTGHPIRDSRALDVPRTAACFRYFGGMADKL 127 Query: 141 QGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200 QG IP+D F Y + PIGV GQI+PWNFPL+ WK+GPAL+ GNTVV+KP+E TPL Sbjct: 128 QGSVIPVDTGFLNYVQRAPIGVVGQIVPWNFPLMFTSWKMGPALAAGNTVVLKPSEITPL 187 Query: 201 TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGK 260 + L + L+ E GFP GVVNIVPGYG TAG ++ H + K+AFTGST G+ I E A + Sbjct: 188 STLRIVELMAEVGFPAGVVNIVPGYGHTAGQRLAEHPGVGKIAFTGSTATGRRIVE-ASQ 246 Query: 261 SNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFV 320 NLKRV LELGGK IV DA+LD A+ A +F++QGQ CIA SR+ + E I D F+ Sbjct: 247 GNLKRVQLELGGKGANIVFDDANLDAAINGAAWAIFHNQGQACIAGSRLVLHERIADAFL 306 Query: 321 RRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNK-- 378 R V A +GNPL P GP K+ D++L ++ +++G ++ GG + Sbjct: 307 ERFVALASSIRIGNPLDPNTEMGPLTSKQHLDRVLSYVDVAREQGGRVLTGGSAPQDPAL 366 Query: 379 --GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKD 436 GY+V+PT+ R+A+EE+FGP +++F S D+ + AN T YGL +G++T D Sbjct: 367 ANGYYVRPTIVEAKHATDRVAQEEVFGPFVTVLRFGSDDEALAIANATEYGLGSGLWTND 426 Query: 437 IDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKI 496 + +A +++ + AG W+NCY V+ PFGG SG GRE+G H+YTE ++V V + Sbjct: 427 LSRAHRMAARIDAGMCWINCYKRVNPGSPFGGVGKSGYGREMGFEAMHDYTEARSVWVNV 486 Query: 497 SQK 499 Sbjct: 487 DGN 489 >3RHO-A nrPDB Length = 517 Score = 589 bits (1518), Expect = e-168, Method: Composition-based stats. Identities = 236/487 (48%), Positives = 323/487 (66%), Gaps = 8/487 (1%) Query: 16 LKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGS 75 L++ Y ++FI E+ D+ K + NP +CQV DVDKAV AA++AF+ G Sbjct: 33 LQMPY-QLFIGGEFVDAEGSKTYNTINPTDGSVICQVSLAQVSDVDKAVAAAKEAFENGL 91 Query: 76 PWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAG 135 W ++A +RGRLLY+LAD++E+ + LAT+E+++ G +Y+ A + I+T RY AG Sbjct: 92 -WGKINARDRGRLLYRLADVMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAG 150 Query: 136 WADKIQGRTIPI----DGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVV 191 W DKIQG TIPI T T+ EP+GVCG +IPWN+PL+ML WK L+ GNTVV Sbjct: 151 WCDKIQGATIPINQARPNRNLTLTKKEPVGVCGIVIPWNYPLMMLSWKTAACLAAGNTVV 210 Query: 192 VKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVG 251 +KPA+ TPLTAL A L +AG P GVVNI+PG G G +S H D+ K+ FTGSTEVG Sbjct: 211 IKPAQVTPLTALKFAELTLKAGIPKGVVNILPGSGSLVGQRLSDHPDVRKIGFTGSTEVG 270 Query: 252 KLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFV 311 K I ++ SN+K+V+L+LGGKSP I+ AD DL+ AV+ VF+++G+ CIAA R+FV Sbjct: 271 KHIMKSCALSNVKKVSLQLGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFV 330 Query: 312 EESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECG 371 EESI+++FV++ VE +K +GNPL GPQ + K+++ + G KEGA L CG Sbjct: 331 EESIHNQFVQKVVEEVEKMKIGNPLERDTNHGPQNHEAHLRKLVEYCQRGVKEGATLVCG 390 Query: 372 GGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFK--SLDDVIKRANNTFYGLS 429 G G+F QPTVF++V D M IAKEE FGP+ I +F +D V+ RAN T +GL+ Sbjct: 391 GNQVPRPGFFFQPTVFTDVEDHMYIAKEESFGPIMIISRFADGDVDAVLSRANATEFGLA 450 Query: 430 AGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEV 489 +GVFT+DI+KA+ +S LQAGTV++N Y PFGGFK SG G++LGE +EY + Sbjct: 451 SGVFTRDINKALYVSDKLQAGTVFINTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRI 510 Query: 490 KTVTVKI 496 KTVT + Sbjct: 511 KTVTFEY 517 >3IWK-A nrPDB Length = 503 Score = 580 bits (1496), Expect = e-166, Method: Composition-based stats. Identities = 201/493 (40%), Positives = 286/493 (58%), Gaps = 12/493 (2%) Query: 16 LKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQA--FQI 73 + + ++FI+ EW + K+ P NP+TE + + KEDVD AV AA++A + Sbjct: 3 ITVSSRQLFIDGEWRVPILNKRIPNINPSTENIIGDIPAATKEDVDLAVDAAKRAISRKN 62 Query: 74 GSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYC 133 G W S R R L +A I+ + L +ES++ GK A L DL + Y Sbjct: 63 GRDWSAASGSLRARYLRAIAAKIKEKKDELGKLESIDCGKPLEEA-LADLDDVVACFEYY 121 Query: 134 AGWADKIQGR-----TIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGN 188 AG A+++ + ++P+D F +Y EPIGV I PWN+P +M WKI PAL+ G Sbjct: 122 AGLAEELDSKQKAPISLPMD-TFKSYILKEPIGVVALITPWNYPFLMATWKIAPALAAGC 180 Query: 189 TVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGST 248 ++KP+E +T L + + KE G P GV+NIV G G AGA+++SH D+DK++FTGS+ Sbjct: 181 AAILKPSELASVTCLELGEICKEVGLPRGVLNIVTGLGHEAGASLASHPDVDKISFTGSS 240 Query: 249 EVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASR 308 G I A + +K V+LELGGKSP +V D DLD E+ G F+ GQ C A SR Sbjct: 241 ATGSKIMTTAAQL-VKPVSLELGGKSPIVVFEDVDLDKVAEWTVFGCFFTNGQICSATSR 299 Query: 309 IFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKL 368 + V ESI EFV + V+ A+ + +PL G GP + + QY K+L+ I S K EGA + Sbjct: 300 LIVHESIAVEFVDKLVKWAENIKISDPLEEGCRLGPIVSEAQYKKVLNCISSAKSEGATI 359 Query: 369 ECGGGPWGN--KGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFY 426 GG + KGYFV+PT+ ++VT M+I +EE+FGPV + F + ++ I AN+T Y Sbjct: 360 LTGGRRPEHLKKGYFVEPTIITDVTTSMQIWREEVFGPVLAVKTFSTEEEAINLANDTHY 419 Query: 427 GLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEY 486 GL + V + D+++ +S ALQAG VW+NC Q P+GG K SG GRELGE+G Y Sbjct: 420 GLGSAVMSNDLERCERLSKALQAGIVWINCAQPSFIQAPWGGIKRSGFGRELGEWGLENY 479 Query: 487 TEVKTVTVKISQK 499 VK VT S + Sbjct: 480 LSVKQVTRYTSDE 492 >3IWJ-A nrPDB Length = 503 Score = 579 bits (1492), Expect = e-165, Method: Composition-based stats. Identities = 205/494 (41%), Positives = 291/494 (58%), Gaps = 12/494 (2%) Query: 15 DLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAF--Q 72 D+ I ++FIN +W V K+ PV NPAT+ + + KEDVD AV AA+ A Sbjct: 2 DIPIPTRQLFINGDWKAPVLNKRIPVINPATQNIIGDIPAATKEDVDVAVAAAKTALTRN 61 Query: 73 IGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRY 132 G+ W T + R R L +A + + LA +ES++ GK A D+ Y Sbjct: 62 KGADWATASGAVRARYLRAIAAKVTEKKPELAKLESIDCGKPLDEAAW-DIDDVAGCFEY 120 Query: 133 CAGWADKIQGR-----TIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCG 187 A A+K+ R ++P+D F ++ EPIGV G I PWN+P++M WK+ PAL+ G Sbjct: 121 YADLAEKLDARQKAPVSLPMD-TFKSHVLREPIGVVGLITPWNYPMLMATWKVAPALAAG 179 Query: 188 NTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGS 247 ++KP+E LT L + + KE G PPGV+NI+ G GP AGA +++H D+DKVAFTGS Sbjct: 180 CAAILKPSELASLTCLELGEICKEVGLPPGVLNILTGLGPEAGAPLATHPDVDKVAFTGS 239 Query: 248 TEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAAS 307 + G I AA + +K V+LELGGKSP +V D DLD A E+A G F+ GQ C A S Sbjct: 240 SATGSKIMTAAAQL-VKPVSLELGGKSPLVVFEDVDLDKAAEWAIFGCFWTNGQICSATS 298 Query: 308 RIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAK 367 R+ + ESI EF+ R V+ K + +PL G GP + + QY+KIL + + K EGA Sbjct: 299 RLILHESIATEFLNRIVKWIKNIKISDPLEEGCRLGPVVSEGQYEKILKFVSNAKSEGAT 358 Query: 368 LECGGGPWGN--KGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTF 425 + GG + KG+F++PT+ ++VT M+I +EE+FGPV + F + ++ I AN+T Sbjct: 359 ILTGGSRPEHLKKGFFIEPTIITDVTTNMQIWREEVFGPVLCVKTFSTEEEAIDLANDTV 418 Query: 426 YGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHE 485 YGL A V + D+++ ++ A +AG VWVNC Q P+GG K SG GRELGE+G Sbjct: 419 YGLGAAVISNDLERCERVTKAFKAGIVWVNCSQPCFTQAPWGGVKRSGFGRELGEWGLDN 478 Query: 486 YTEVKTVTVKISQK 499 Y VK VT IS++ Sbjct: 479 YLSVKQVTQYISEE 492 >6B4R-B nrPDB Length = 497 Score = 579 bits (1492), Expect = e-165, Method: Composition-based stats. Identities = 209/499 (41%), Positives = 308/499 (61%), Gaps = 5/499 (1%) Query: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60 M++ D DLKI+ + F+N E+ ++ SG+ F +P L +V D D Sbjct: 1 MTTLTRADWEARAKDLKIEG-RAFVNGEYSNAASGETFDCLSPVDGRFLAKVASCDLADA 59 Query: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120 ++AVK AR AF G+ W + ++R + + + ADL+ + LA +E+++ GK S++ Sbjct: 60 EQAVKVARNAFDSGA-WSRLAPAKRKQTMIRFADLLLENAEELALLETLDMGKPISDSLH 118 Query: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180 D+A +LR+ A DKI EP+GV I+PWNFPL+M WK+ Sbjct: 119 IDVASAANSLRWSAEAIDKIYDEVAATPHAELGLVTREPVGVVAAIVPWNFPLLMSCWKL 178 Query: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240 GPAL+ GN+V++KP+E++PLTA+ +A L EAG P GV N++PGYG T G A++ HMD+D Sbjct: 179 GPALATGNSVILKPSEKSPLTAIRIAQLAVEAGIPKGVFNVLPGYGHTVGKALALHMDVD 238 Query: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADA-DLDNAVEFAHHGVFYHQ 299 + FTGST++ K + AG+SN+KRV LE GGKSP IV ADA DL A E A + ++Q Sbjct: 239 TLVFTGSTKIAKQLMVYAGESNMKRVWLEAGGKSPNIVFADAPDLKAAAEAAAGAIAFNQ 298 Query: 300 GQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIE 359 G+ C A SR+ VE SI D+F+ +E K + GNPL P G +D +Q + +L IE Sbjct: 299 GEVCTAGSRLLVERSIKDKFLPLVIEALKGWKPGNPLDPETNVGALVDTQQMNTVLSYIE 358 Query: 360 SGKKEGAKLECGGGPWGNK--GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDV 417 +G +GAKL GG + G +V+PT+F VT+ M+IA+EEIFGPV +++F+ ++ Sbjct: 359 AGHNDGAKLVAGGKRTLEETGGTYVEPTIFDGVTNAMKIAREEIFGPVLSVIEFEDAEEA 418 Query: 418 IKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRE 477 ++ AN+T YGL+A V+T ++ KA + AL+AG+VWVN Y PFGGFK SGNGR+ Sbjct: 419 VRIANDTPYGLAAAVWTSNLSKAHLTAKALRAGSVWVNQYDGGDMTAPFGGFKQSGNGRD 478 Query: 478 LGEYGFHEYTEVKTVTVKI 496 + F +YTE+K +K+ Sbjct: 479 KSLHAFDKYTELKATWIKL 497 >4MPY-A nrPDB Length = 520 Score = 572 bits (1475), Expect = e-163, Method: Composition-based stats. Identities = 193/485 (39%), Positives = 279/485 (57%), Gaps = 8/485 (1%) Query: 16 LKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGS 75 LK + +I+ EW +S + + NP +E + V EG KED ++A+ AAR+AF+ G Sbjct: 28 LKHLSQRQYIDGEWVESANKNTRDIINPYNQEVIFTVSEGTKEDAERAILAARRAFESG- 86 Query: 76 PWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAG 135 W A RG+ + +AD I+ R LA +E+++ GK +Y D+ Y AG Sbjct: 87 EWSQETAETRGKKVRAIADKIKEHREALARLETLDTGKTLEESY-ADMDDIHNVFMYFAG 145 Query: 136 WADKIQGRTIPID-GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKP 194 ADK G I + + EP+GV QI PWN+PL+ WKI PAL+ G ++V+KP Sbjct: 146 LADKDGGEMIDSPIPDTESKIVKEPVGVVTQITPWNYPLLQASWKIAPALATGCSLVMKP 205 Query: 195 AEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLI 254 +E TPLT + V L++E GFP G +N++ G G G +S H ++D V+FTG E GK I Sbjct: 206 SEITPLTTIRVFELMEEVGFPKGTINLILGAGSEVGDVMSGHKEVDLVSFTGGIETGKHI 265 Query: 255 KEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEES 314 + A +N+ + LELGGK+P I+ DAD + AV+ A +G ++H GQ C A SRI V+ S Sbjct: 266 MKNAA-NNVTNIALELGGKNPNIIFDDADFELAVDQALNGGYFHAGQVCSAGSRILVQNS 324 Query: 315 IYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGP 374 I D+F + ++R KK LGN GP I E +KI ++ K EGA + GG Sbjct: 325 IKDKFEQALIDRVKKIKLGNGFDADTEMGPVISTEHRNKIESYMDVAKAEGATIAVGGKR 384 Query: 375 WGNK----GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSA 430 G F +PTV +N MRI +EE+FGPV + F++ + I+ AN++ YGL+ Sbjct: 385 PDRDDLKDGLFFEPTVITNCDTSMRIVQEEVFGPVVTVEGFETEQEAIQLANDSIYGLAG 444 Query: 431 GVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVK 490 VF+KDI KA +++ L+ GTVW+N + AQ P+GG+K SG GRELG+ G EY K Sbjct: 445 AVFSKDIGKAQRVANKLKLGTVWINDFHPYFAQAPWGGYKQSGIGRELGKEGLEEYLVSK 504 Query: 491 TVTVK 495 + Sbjct: 505 HILTN 509 >4GO4-A nrPDB Length = 495 Score = 571 bits (1472), Expect = e-163, Method: Composition-based stats. Identities = 206/483 (42%), Positives = 300/483 (62%), Gaps = 9/483 (1%) Query: 21 TKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80 +++I+ + D+V+G V +P + ++ + DVD AV AA++AF W + Sbjct: 3 NQLYIDGRFVDAVAGGTIDVVSPHDGSLITRIAAAEAADVDLAVAAAKRAF---PAWSAL 59 Query: 81 DASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI 140 A+ERGRLL KLAD IE LA +ES+N G ++ D+ RY G ADKI Sbjct: 60 GAAERGRLLLKLADRIEECSEELAQLESLNTGHPIRDSRGLDVPRTAACFRYFGGMADKI 119 Query: 141 QGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200 +G IP+D F Y + +PIGV QI+PWNFPL+ WK+GPAL+ GNT+V+KP+E TPL Sbjct: 120 EGSVIPVDAGFLNYVQRKPIGVVAQIVPWNFPLMFTSWKMGPALAAGNTIVIKPSEITPL 179 Query: 201 TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGK 260 + L + L+ E GFP GVVN+VPGYG TAG A++ H+D+ K+AFTGST G+ I E A K Sbjct: 180 STLRIVELMTEVGFPKGVVNVVPGYGHTAGQALAEHLDVGKIAFTGSTATGRRIVE-ASK 238 Query: 261 SNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFV 320 SNLKR+ LELGGK IV DA+++ AV A +F++QGQ CIA SR+ + + I D+F+ Sbjct: 239 SNLKRIQLELGGKGANIVFEDANIEAAVNGAAWAIFHNQGQACIAGSRLILHKDIADQFL 298 Query: 321 RRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNK-- 378 R + AK LG+P+ P GP + D++L I+ ++G K+ GG +K Sbjct: 299 ERFIALAKSIRLGDPMDPETEMGPLTSALRRDRVLSYIDIAIEQGGKVLAGGKAPDDKAL 358 Query: 379 --GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKD 436 G++V+PTV + R+ +EE+FGP +++F S ++ + ANNT YGL +G++T++ Sbjct: 359 ANGFYVEPTVVE-AKPQDRVCQEEVFGPFVTVVRFSSDEEALAIANNTEYGLGSGLWTQN 417 Query: 437 IDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKI 496 + +A ++ A+ AG W+NCY VS PFGG SG GRE+G H+YTE ++V V + Sbjct: 418 LARAHKMAHAIHAGMCWINCYKRVSPGSPFGGVGQSGYGREMGFEAIHDYTEARSVWVNV 477 Query: 497 SQK 499 K Sbjct: 478 DAK 480 >5IUV-A nrPDB Length = 497 Score = 571 bits (1471), Expect = e-163, Method: Composition-based stats. Identities = 204/499 (40%), Positives = 302/499 (60%), Gaps = 5/499 (1%) Query: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60 M++ D +LKI+ + FI E+ + SG+ F +P L +V D D Sbjct: 1 MTTLTRADWEQRAQNLKIEG-RAFIQGEYTAAASGETFDCISPVDGRLLAKVASCDAADA 59 Query: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120 +AV++AR AF G+ W + ++R + + A L+E++ LA +E+++ GK S++ Sbjct: 60 QRAVESARSAFDSGA-WSRLAPAKRKATMIRFAGLLEQNAEELALLETLDMGKPISDSLG 118 Query: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180 D+ G + L + DK+ + EP+GV I+PWNFPL+M WK+ Sbjct: 119 VDIPGGARALSWSGEAIDKLYDEVAATPHDQLGLVTREPVGVVAAIVPWNFPLMMACWKL 178 Query: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240 GPALS GN+VV+KP+E++PLTA+ +A L EAG P GV+N++PGYG T G A++ HMD+D Sbjct: 179 GPALSTGNSVVLKPSEKSPLTAIRIAQLAIEAGIPAGVLNVLPGYGHTVGKALALHMDVD 238 Query: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADA-DLDNAVEFAHHGVFYHQ 299 V FTGST++ K + AG+SN+KRV LE GGKSP IV ADA DL A + A + ++Q Sbjct: 239 TVVFTGSTKIAKQLMIYAGESNMKRVWLEAGGKSPNIVFADAPDLQAAADSAASAIAFNQ 298 Query: 300 GQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIE 359 G+ C A SR+ VE SI D F+ +E + GNPL P G +D +Q + +L I Sbjct: 299 GEVCTAGSRLLVERSIKDRFLPMVIEALGTWKPGNPLDPATNVGALVDTQQMNTVLSYIA 358 Query: 360 SGKKEGAKLECGGGPWGNK--GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDV 417 +G +GA+L GG + G +V+PT+F V + MRIA+EEIFGPV ++ F + ++ Sbjct: 359 AGHTDGARLVAGGKQILQETGGTYVEPTIFDGVNNAMRIAQEEIFGPVLSVLTFDTAEEA 418 Query: 418 IKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRE 477 I+ AN+T YGL+A V+T ++ KA + AL+AG+VWVN Y PFGGFK SGNGR+ Sbjct: 419 IQIANDTPYGLAAAVWTANLSKAHLTARALRAGSVWVNQYDGGDMTAPFGGFKQSGNGRD 478 Query: 478 LGEYGFHEYTEVKTVTVKI 496 + F +YTE+K+ +K+ Sbjct: 479 KSLHAFDKYTELKSTWIKL 497 >3JZ4-A nrPDB Length = 481 Score = 570 bits (1470), Expect = e-163, Method: Composition-based stats. Identities = 175/485 (36%), Positives = 272/485 (56%), Gaps = 6/485 (1%) Query: 13 LTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQ 72 L D + + IN EW D+ +G+ V NPA ++L V + ++ A+ AA +A Sbjct: 2 LNDSNLFRQQALINGEWLDANNGEAIDVTNPANGDKLGSVPKMGADETRAAIDAANRAL- 60 Query: 73 IGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRY 132 WR + A ER +L +L+ + LA + ++ GK + A +++ + + Sbjct: 61 --PAWRALTAKERATILRNWFNLMMEHQDDLARLMTLEQGKPLAEAK-GEISYAASFIEW 117 Query: 133 CAGWADKIQGRTIPI-DGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVV 191 A +I G TIP + +PIGV I PWNFP M+ K GPAL+ G T+V Sbjct: 118 FAEEGKRIYGDTIPGHQADKRLIVIKQPIGVTAAITPWNFPAAMITRKAGPALAAGCTMV 177 Query: 192 VKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVG 251 +KPA QTP +AL +A L AG P GV N+V G G ++S+ + K++FTGSTE+G Sbjct: 178 LKPASQTPFSALALAELAIRAGVPAGVFNVVTGSAGAVGNELTSNPLVRKLSFTGSTEIG 237 Query: 252 KLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFV 311 + + E K ++K+V+LELGG +P IV DADLD AVE A F + GQ C+ A+R++V Sbjct: 238 RQLMEQCAK-DIKKVSLELGGNAPFIVFDDADLDKAVEGALASKFRNAGQTCVCANRLYV 296 Query: 312 EESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECG 371 ++ +YD F + + K +G+ L GVT GP ID++ K+ + I ++GA++ CG Sbjct: 297 QDGVYDRFAEKLQQAMSKLHIGDGLDNGVTIGPLIDEKAVAKVEEHIADALEKGARVVCG 356 Query: 372 GGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAG 431 G G F QPT+ +V +++KEE FGP+ + +FK DVI +AN+T +GL+A Sbjct: 357 GKAHERGGNFFQPTILVDVPANAKVSKEETFGPLAPLFRFKDEADVIAQANDTEFGLAAY 416 Query: 432 VFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKT 491 + +D+ + + AL+ G V +N + + PFGG K SG GRE +YG +Y E+K Sbjct: 417 FYARDLSRVFRVGEALEYGIVGINTGIISNEVAPFGGIKASGLGREGSKYGIEDYLEIKY 476 Query: 492 VTVKI 496 + + + Sbjct: 477 MCIGL 481 >6QAO-A nrPDB Length = 508 Score = 569 bits (1467), Expect = e-162, Method: Composition-based stats. Identities = 190/486 (39%), Positives = 278/486 (57%), Gaps = 13/486 (2%) Query: 23 IFINNEWHDSVSGK-KFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 + + F PAT + +++V+ AV+ A+ AF+I W Sbjct: 27 NYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKS 83 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 ER R+L + A +I +ATME +N GK A L D+ + L Y AG A + Sbjct: 84 GMERCRILLEAARIIREREDEIATMECINNGKSIFEARL-DIDISWQCLEYYAGLAASMA 142 Query: 142 GRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLT 201 G I + G F YTR EP+GVC I WN+P + WK PAL+CGN +V KP+ TP++ Sbjct: 143 GEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVS 202 Query: 202 ALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKS 261 AL +A + EAG PPG+ N+V G G G + H D+ KV+FTGS G I E + K Sbjct: 203 ALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG 261 Query: 262 NLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVR 321 +K VTLELGGKSP I+ +D D++NAV+ A F QGQ C +R+FV++ I D+F Sbjct: 262 -IKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTE 320 Query: 322 RSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG------PW 375 V++ ++ +G+PL GP I++ +++L ++ K++GAK+ CGG P Sbjct: 321 EVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPK 380 Query: 376 GNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435 GY+++P V +N D+M KEEIFGPV I+ F + +V++RAN+T +GL+AGVFT+ Sbjct: 381 LKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTR 440 Query: 436 DIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495 DI +A + + LQAGT ++N Y V + PFGG+K SG GRE G Y+++KTV V+ Sbjct: 441 DIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 500 Query: 496 ISQKNS 501 + S Sbjct: 501 MGDVES 506 >1BPW-A nrPDB Length = 503 Score = 568 bits (1464), Expect = e-162, Method: Composition-based stats. Identities = 196/486 (40%), Positives = 287/486 (59%), Gaps = 13/486 (2%) Query: 23 IFINNEWHDSVSGKK-FPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 + S G PVF PAT LCQ+ E+VD+AV++A+ A+ W M Sbjct: 22 NYWGGRRIKSKDGATTEPVFEPATGRVLCQMVPCGAEEVDQAVQSAQAAYL---KWSKMA 78 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 ER R++ + A +I R +A +E +N GK + A D+ + + Y AG A + Sbjct: 79 GIERSRVMLEAARIIRERRDNIAKLEVINNGKTITEAEY-DIDAAWQCIEYYAGLAPTLS 137 Query: 142 GRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLT 201 G+ I + G F YTR EP+GVC I+ WN+P ++ WK PAL+CGN VV KP+ TP+T Sbjct: 138 GQHIQLPGGAFAYTRREPLGVCAGILAWNYPFMIAAWKCAPALACGNAVVFKPSPMTPVT 197 Query: 202 ALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKS 261 + +A + EAG P G+VN+V G G G+ + H ++ KV+FTGS GK + E + K+ Sbjct: 198 GVILAEIFHEAGVPVGLVNVVQG-GAETGSLLCHHPNVAKVSFTGSVPTGKKVMEMSAKT 256 Query: 262 NLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVR 321 +K VTLELGGKSP ++ D +L+NAV A F QGQ C +R+FV+ I +F+ Sbjct: 257 -VKHVTLELGGKSPLLIFKDCELENAVRGALMANFLTQGQVCTNGTRVFVQREIMPQFLE 315 Query: 322 RSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG----- 376 V+R K ++G+PL G I K Q DK+L + KKEGA++ CGG P Sbjct: 316 EVVKRTKAIVVGDPLLTETRMGGLISKPQLDKVLGFVAQAKKEGARVLCGGEPLTPSDPK 375 Query: 377 -NKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435 GYF+ P V N D+M KEEIFGPV ++ F + ++V++RANNT +GL++GVFT+ Sbjct: 376 LKNGYFMSPCVLDNCRDDMTCVKEEIFGPVMSVLPFDTEEEVLQRANNTTFGLASGVFTR 435 Query: 436 DIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495 DI +A +++ L+AGT ++N Y + + PFGG+KMSG GRE G+ Y+++KTV V+ Sbjct: 436 DISRAHRVAANLEAGTCYINTYSISPVEVPFGGYKMSGFGRENGQATVDYYSQLKTVIVE 495 Query: 496 ISQKNS 501 + +S Sbjct: 496 MGDVDS 501 >4I8P-A nrPDB Length = 520 Score = 564 bits (1454), Expect = e-161, Method: Composition-based stats. Identities = 201/499 (40%), Positives = 283/499 (56%), Gaps = 12/499 (2%) Query: 10 PVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQ 69 P + + ++F++ EW G++ PV NP TE + ++ G EDVD AV AAR Sbjct: 14 PNSASPAMVPLRQLFVDGEWRPPAQGRRLPVVNPTTEAHIGEIPAGTAEDVDAAVAAARA 73 Query: 70 AFQI--GSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCI 127 A + G W + R + L +A + + LA +E+++ GK Y A D+ Sbjct: 74 ALKRNRGRDWARAPGAVRAKYLRAIAAKVIERKPELAKLEALDCGKPYDEAAW-DMDDVA 132 Query: 128 KTLRYCAGWADKIQGR-----TIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGP 182 Y A A+ + R ++P++ F + R EPIGV G I PWN+PL+M WKI P Sbjct: 133 GCFEYFADQAEALDKRQNSPVSLPME-TFKCHLRREPIGVVGLITPWNYPLLMATWKIAP 191 Query: 183 ALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKV 242 AL+ G T V+KP+E +T L +A + KE G P GV+NIV G GP AGA +S+H D+DKV Sbjct: 192 ALAAGCTAVLKPSELASVTCLELADICKEVGLPSGVLNIVTGLGPDAGAPLSAHPDVDKV 251 Query: 243 AFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQC 302 AFTGS E GK I +A +K VTLELGGKSP +V D D+D AVE+ G F+ GQ Sbjct: 252 AFTGSFETGKKIMASAA-PMVKPVTLELGGKSPIVVFDDVDIDKAVEWTLFGCFWTNGQI 310 Query: 303 CIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGK 362 C A SR+ + I +F R V AK + +PL G GP + + QY+KI I + K Sbjct: 311 CSATSRLLIHTKIAKKFNERMVAWAKNIKVSDPLEEGCRLGPVVSEGQYEKIKKFISNAK 370 Query: 363 KEGAKLECGGGPWG--NKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR 420 +GA + GG KG+F++PT+ +++T M I +EE+FGPV + +F + D+ I+ Sbjct: 371 SQGATILTGGVRPAHLEKGFFIEPTIITDITTSMEIWREEVFGPVLCVKEFSTEDEAIEL 430 Query: 421 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE 480 AN+T YGL+ V + D ++ +S + AG +WVNC Q P+GG K SG GRELGE Sbjct: 431 ANDTQYGLAGAVISGDRERCQRLSEEIDAGCIWVNCSQPCFCQAPWGGNKRSGFGRELGE 490 Query: 481 YGFHEYTEVKTVTVKISQK 499 G Y VK VT IS + Sbjct: 491 GGIDNYLSVKQVTEYISDE 509 >4QYJ-A nrPDB Length = 516 Score = 562 bits (1448), Expect = e-160, Method: Composition-based stats. Identities = 215/483 (44%), Positives = 302/483 (62%), Gaps = 10/483 (2%) Query: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 ++ I +W + SGK V+NPAT + L +V +GD EDV+ AV++A A WR M Sbjct: 36 QMLIGGQWVSAQSGKTLNVYNPATGDILTEVPDGDVEDVNAAVESA-AATLRSDTWRRMP 94 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 S R R+L +LADL+E LA +E++N GKL + L ++ + LRY AGWA K+ Sbjct: 95 PSARERILLRLADLLEVHGDELARLETLNNGKLLIYSKLMEVGASAQWLRYMAGWATKLT 154 Query: 142 GRTI------PIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPA 195 G T+ P + T+ P+GV IIPWNFPL+M +WKI PAL+CGNTVV+KPA Sbjct: 155 GSTLDLSLPLPPEVRSRASTQRVPVGVVAAIIPWNFPLLMAVWKIAPALACGNTVVLKPA 214 Query: 196 EQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIK 255 E+TPLTAL +A L EAG P G +N+V G G TAG A+ H + KVAFTGSTEVG++I Sbjct: 215 EETPLTALRLAELAMEAGLPAGALNVVTGRGETAGDALVRHPKVAKVAFTGSTEVGRIIG 274 Query: 256 EAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESI 315 A G+S LK V+LELGGKSP IVLAD D A E A +F++ GQ C A SR++V ESI Sbjct: 275 SACGRS-LKAVSLELGGKSPVIVLADCDPQEAAEGAAAAIFFNHGQVCTAGSRLYVHESI 333 Query: 316 YDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPW 375 Y++ ++R + ++G+ L GV GP + K+ ++ +L I +G ++GA L CGG Sbjct: 334 YEDVIQRLAVIGESIVVGSGLEQGVHMGPMVSKKHHENVLRHIRNGIEDGADLICGGTEA 393 Query: 376 G-NKGYFVQPTVFSNV-TDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVF 433 +G+FV+PT+F+N ++R+ +E+FGPV F + +V+ AN + YGL A ++ Sbjct: 394 PCAQGFFVKPTIFANREKKDIRLLSQEVFGPVLVATPFSDIAEVVNEANRSVYGLGASIW 453 Query: 434 TKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVT 493 T D+ A+ I+ L+AGTVWVN + +V PFGGFK SG GRE G YT +++ Sbjct: 454 TNDLSAALRINDELEAGTVWVNTHNMVDPNLPFGGFKDSGVGREHGAAAIEHYTTTRSLV 513 Query: 494 VKI 496 + Sbjct: 514 IAY 516 >4I8Q-A nrPDB Length = 514 Score = 560 bits (1444), Expect = e-160, Method: Composition-based stats. Identities = 184/497 (37%), Positives = 279/497 (56%), Gaps = 10/497 (2%) Query: 10 PVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQ 69 ++ I +++I EW + V + P+ NPATEE + + EDVD AV+AAR+ Sbjct: 13 DPANRNVPIPRRQLYIGGEWREPVKKNRIPIINPATEEIIGDIPAATAEDVDIAVEAARK 72 Query: 70 AFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKT 129 A W + ++R + L +A + + +LAT+ES++ GK + D+ Sbjct: 73 AI-ARDDWGSTTGAQRAKYLRAIAAKVLEKKSVLATLESLDSGKTLYES-AADMDDVAGC 130 Query: 130 LRYCAGWADKIQGRTIPI----DGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALS 185 Y AG A+ + R + ++ +Y EP+GV G I PWN+PL+M IWK+ PAL+ Sbjct: 131 FEYYAGLAEALDSRRMTPVNLNSDSYKSYVLREPLGVVGLITPWNYPLLMAIWKVAPALA 190 Query: 186 CGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFT 245 G ++KP+E +T L + + +E G P G +NI+ G GP AG ++SH +DK++FT Sbjct: 191 AGCAAILKPSELASITCLELGEICREIGLPSGALNILTGLGPEAGGPLASHPHVDKISFT 250 Query: 246 GSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADAD-LDNAVEFAHHGVFYHQGQCCI 304 GS G I AA + +K V+L LGGKSP +V D D LD A E+ G+F + GQ C Sbjct: 251 GSGPTGSKIMTAAAQL-VKPVSLALGGKSPIVVFDDIDNLDIAAEWTLFGIFANTGQVCS 309 Query: 305 AASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKE 364 A SR+ V+E+I F+ R ++ K + +PL GP + QY+K+L I + K E Sbjct: 310 ATSRLIVQENIASAFMDRLLKWTKNIKISDPLEEDCKLGPVVSAGQYEKVLKFISNAKSE 369 Query: 365 GAKLECGGGPWGN--KGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRAN 422 GA + CGG + KGY+VQPT+ ++V M I KEE+FGPV + FK+ + I+ AN Sbjct: 370 GATILCGGERPQHLKKGYYVQPTIITDVNTSMEIWKEEVFGPVLCVKTFKTEEQAIELAN 429 Query: 423 NTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYG 482 +T YGL A V +KD+ + + A Q G +W+NC + P+GG K SG GR+LG++G Sbjct: 430 DTKYGLGAAVMSKDVKRCERFTKAFQTGIIWINCSQPTFNELPWGGKKRSGFGRDLGKWG 489 Query: 483 FHEYTEVKTVTVKISQK 499 + +K VT S + Sbjct: 490 LENFLNIKQVTEYTSAE 506 >4O5H-A nrPDB Length = 511 Score = 556 bits (1433), Expect = e-158, Method: Composition-based stats. Identities = 221/482 (45%), Positives = 296/482 (61%), Gaps = 8/482 (1%) Query: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 ++ I EW D+ SG++ V NPA + +V E D+ DV +AV AAR+AF G PWRT Sbjct: 32 QMLIGAEWSDAASGRQLDVVNPADGTVIARVPEADERDVQQAVAAARRAFDAG-PWRTAK 90 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 ++R RL+ LADLIE + LA +ES++ GK A D+A + RY AGWA KI+ Sbjct: 91 TTDRERLMLVLADLIEANARELAEIESLDNGKPVMVAQGLDVAMAAQCFRYMAGWATKIE 150 Query: 142 GRTIPI------DGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPA 195 G I D F YTR EP+GV G IIPWNFPL+M WKI PAL+ G TVV+KPA Sbjct: 151 GSVIDAGMPYLPDSEIFAYTRKEPVGVVGAIIPWNFPLLMAAWKIAPALATGCTVVLKPA 210 Query: 196 EQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIK 255 E TPL+AL + LI+ AGFP GVVNIV GYG TAGAA+S IDK+AFTGST+ GK I Sbjct: 211 EDTPLSALRLGELIQAAGFPDGVVNIVTGYGHTAGAALSRDPRIDKIAFTGSTQTGKTIG 270 Query: 256 EAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESI 315 A N+ R++LELGGKSP IVL D DLD A + + +F++QGQ C A SR ++ + Sbjct: 271 H-AALDNMTRMSLELGGKSPVIVLPDVDLDKAAQGVANAIFFNQGQVCTAGSRAYIHSKV 329 Query: 316 YDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPW 375 +D + R + A +G + P GP + +Q +++ I+SG EGA+ GG Sbjct: 330 FDGVIERVAKIAASLKIGPGMDPATQIGPLVSAKQRERVCGYIDSGFGEGARAAAGGRAI 389 Query: 376 GNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435 G+FV+PTV + T MR+ +EEIFGPV M F +D ++ AN+T YGL A +++ Sbjct: 390 DGPGFFVEPTVLVDTTQAMRVVREEIFGPVLVAMPFDDVDTAVQLANDTPYGLGASIWSN 449 Query: 436 DIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495 D+ + + AGTVWVNC+ ++ PFGG K SG GRELG +YTE K+V + Sbjct: 450 DLSAIHKLVPRIAAGTVWVNCHSLLDNALPFGGMKQSGFGRELGRAVIDQYTESKSVMMN 509 Query: 496 IS 497 + Sbjct: 510 YA 511 >2D4E-A nrPDB Length = 515 Score = 554 bits (1429), Expect = e-158, Method: Composition-based stats. Identities = 200/491 (40%), Positives = 298/491 (60%), Gaps = 15/491 (3%) Query: 16 LKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGS 75 LK + FI E+ S SG+ FP +PAT E L G + +VD+A KAA +AFQ Sbjct: 22 LKERPALHFIAGEFVPSESGETFPSLDPATNEVLGVAARGGEREVDRAAKAAHEAFQR-- 79 Query: 76 PWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAG 135 W A ER R L ++A+LIE+ LA ME ++ G++ +A + + A Sbjct: 80 -WSRTKAKERKRYLLRIAELIEKHADELAVMECLDAGQVLRIVR-AQVARAAENFAFYAE 137 Query: 136 WADK-IQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKP 194 +A+ ++ RT P+D ++ YT P G G I PWN PL++ W+I PAL+ GNTVV+KP Sbjct: 138 YAEHAMEDRTFPVDRDWLYYTVRVPAGPVGIITPWNAPLMLSTWRIAPALAFGNTVVLKP 197 Query: 195 AEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLI 254 AE +P TA +A ++KEA PPGV N+V G+G AGAA+ +H + + TG TE GK++ Sbjct: 198 AEWSPFTATKLAEILKEADLPPGVFNLVQGFGEEAGAALVAHPLVPLLTLTGETETGKIV 257 Query: 255 KEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEES 314 A +LKR++ ELGGKSP +V ADADL+ A++ +F G+ C A+SR+ VEE Sbjct: 258 MRNAA-DHLKRLSPELGGKSPALVFADADLERALDAVVFQIFSFNGERCTASSRLLVEEK 316 Query: 315 IYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGP 374 I+++FV + VERA+ +G+PL P GP I E ++L +E+GK+EGA+L GG Sbjct: 317 IFEDFVGKVVERARAIRVGHPLDPETEVGPLIHPEHLQRVLGYVEAGKREGARLLVGGER 376 Query: 375 WG--------NKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFY 426 ++G ++ PTVF + M+IA+EEIFGPV + FK ++ +++AN+T Y Sbjct: 377 AKTSFRGEDLSRGNYLLPTVFVG-ENHMKIAQEEIFGPVLVAIPFKDEEEALRKANDTKY 435 Query: 427 GLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEY 486 GL+A VFT+D+++A ++ L+AG V++N + V PFGG K SG+ RE G Y Y Sbjct: 436 GLAAYVFTRDLERAHRLALELEAGMVYLNSHNVRHLPTPFGGVKGSGDRREGGTYALDFY 495 Query: 487 TEVKTVTVKIS 497 T++KT+ + + Sbjct: 496 TDLKTIALPLR 506 >3R31-A nrPDB Length = 517 Score = 553 bits (1425), Expect = e-158, Method: Composition-based stats. Identities = 193/498 (38%), Positives = 282/498 (56%), Gaps = 11/498 (2%) Query: 9 LPVLLTDLKIQ-YTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAA 67 + + T LK Q FI+ ++ + +G F PAT E + ++ V++A+ +A Sbjct: 2 VMTIATPLKAQPKASHFIDGDYVEDNTGTPFESIFPATGEMIAKLHAATPAIVERAIASA 61 Query: 68 RQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCI 127 ++A + W M RGR+L + AD++ L+T+E+++ GK + D Sbjct: 62 KRAQK---EWAAMSPMARGRILKRAADIMRERNDALSTLETLDTGKPIQETIVADPTSGA 118 Query: 128 KTLRYCAGWA-DKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSC 186 + G A + G IP+ G+F YT+ P+GVC I WN+P + WK PAL Sbjct: 119 DAFEFFGGIAPSALNGDYIPLGGDF-AYTKRVPLGVCVGIGAWNYPQQIACWKAAPALVA 177 Query: 187 GNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTG 246 GN +V KP+E TPL AL +A ++ EAG P G+ N++ G G + +H D+ KV+ TG Sbjct: 178 GNAMVFKPSENTPLGALKIAEILIEAGLPKGLFNVIQGD-RDTGPLLVNHPDVAKVSLTG 236 Query: 247 STEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAA 306 S G+ + AA +LK VT+ELGGKSP IV DAD+++AV A G FY GQ C Sbjct: 237 SVPTGRKVAAAAAG-HLKHVTMELGGKSPMIVFDDADIESAVGGAMLGNFYSSGQVCSNG 295 Query: 307 SRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGA 366 +R+FV++ F+ R + ILG+PL GP + K Q +K+L IE GK EGA Sbjct: 296 TRVFVQKKAKARFLENLKRRTEAMILGDPLDYATHLGPLVSKAQQEKVLSYIEKGKAEGA 355 Query: 367 KLECGGGPWGN---KGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANN 423 L GGG N +G +VQPTVF++VTD+M IA+EEIFGPV ++ F D+V+ RAN Sbjct: 356 TLITGGGIPNNVAGEGAYVQPTVFADVTDDMTIAREEIFGPVMCVLDFDDEDEVLARANA 415 Query: 424 TFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGF 483 T +GL+ GVFT D+ +A + L+AGT+W+N Y + + PFGG K SG GRE Sbjct: 416 TEFGLAGGVFTADLARAHRVVDGLEAGTLWINTYNLCPVEIPFGGSKQSGFGRENSAAAL 475 Query: 484 HEYTEVKTVTVKISQKNS 501 Y+E+KTV V + ++ Sbjct: 476 EHYSELKTVYVSTGKVDA 493 >4V6H-A nrPDB Length = 484 Score = 538 bits (1386), Expect = e-153, Method: Composition-based stats. Identities = 173/488 (35%), Positives = 260/488 (53%), Gaps = 6/488 (1%) Query: 10 PVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQ 69 P + D + + +I EW + S F VF+PAT E L V + + +A Sbjct: 2 PGSMKDPSLLRHQAYIGGEWQAADSDATFEVFDPATGESLGTVPKMGAAE---TARAIEA 58 Query: 70 AFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKT 129 A + WR A ER +L + DL+ + LA + + GK + A ++A Sbjct: 59 AQAAWAGWRMKTAKERAAILRRWFDLVIANSDDLALILTTEQGKPLAEAK-GEIAYAASF 117 Query: 130 LRYCAGWADKIQGRTIPI-DGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGN 188 + + A ++ G T+P D N EPIGVC I PWNFP M+ K+GPAL+ G Sbjct: 118 IEWFAEEGKRVAGDTLPTPDANKRIVVVKEPIGVCAAITPWNFPAAMIARKVGPALAAGC 177 Query: 189 TVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGST 248 +VVKPAE TP +AL +A L + AG P GV+++V G G I+S+ + K++FTGST Sbjct: 178 PIVVKPAESTPFSALAMAFLAERAGVPKGVLSVVIGDPKAIGTEITSNPIVRKLSFTGST 237 Query: 249 EVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASR 308 VG+L+ + +K++TLELGG +P IV DADLD AVE A + + GQ C+ +R Sbjct: 238 AVGRLLMAQSA-PTVKKLTLELGGNAPFIVFDDADLDAAVEGAIASKYRNNGQTCVCTNR 296 Query: 309 IFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKL 368 FV E +YD F + K +G G T GP I++ K+ I +GA L Sbjct: 297 FFVHERVYDAFADKLAAAVSKLKVGRGTESGATLGPLINEAAVKKVESHIADALAKGASL 356 Query: 369 ECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGL 428 GG F +PTV + V +M +AKEE FGP+ + +F S +++++ AN+T +GL Sbjct: 357 MTGGKRHALGHGFFEPTVLTGVKPDMDVAKEETFGPLAPLFRFASEEELVRLANDTEFGL 416 Query: 429 SAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTE 488 +A ++++DI + ++ AL+ G V +N + + PFGG K SG GRE YG +Y Sbjct: 417 AAYLYSRDIGRVWRVAEALEYGMVGINTGLISNEVAPFGGVKQSGLGREGSHYGIDDYVV 476 Query: 489 VKTVTVKI 496 +K + V + Sbjct: 477 IKYLCVAV 484 >5KLK-A nrPDB Length = 520 Score = 529 bits (1364), Expect = e-150, Method: Composition-based stats. Identities = 169/484 (34%), Positives = 260/484 (53%), Gaps = 15/484 (3%) Query: 23 IFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDA 82 +I+ + S S F NP + + V E D + V++AV AA+ A + PW + Sbjct: 42 NYIDGNFVTSAS--SFANINPVNGKLISDVFEADAKQVNEAVVAAQNALK--GPWGKLSV 97 Query: 83 SERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQG 142 +R L++K+AD I+ E + G+ A D+ I R A A Sbjct: 98 QDRAALIHKIADGIQARFEEFVAAEVADTGRPVHQARTLDIPRAIANFRTFADLAKTSHT 157 Query: 143 RTIPID----GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQT 198 + YT +P+GV G I PW+ PL++ WK+ PAL+CGNTVV KP+E++ Sbjct: 158 DLFEMSTSDGSGALNYTVRKPLGVIGVISPWDLPLLLFTWKVAPALACGNTVVAKPSEES 217 Query: 199 PLTALHVASLIKEAGFPPGVVNIVPGYGPT-AGAAISSHMDIDKVAFTGSTEVGKLIKEA 257 P +A +A ++ +AG PPGV N++ G+G AG ++ H I + FTG ++ G I +A Sbjct: 218 PSSATLLAEVMHDAGVPPGVFNLIHGFGKDSAGEFLTQHPGISALTFTGESKTGSTIMKA 277 Query: 258 AGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYD 317 +K V+ ELGGK+ +V ADADLD A+E F + GQ C+ + R++V SI+D Sbjct: 278 VA-DGVKEVSFELGGKNAAVVFADADLDAAIEGVLRSSFTNSGQVCLCSERVYVHRSIFD 336 Query: 318 EFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG- 376 EFV A++ ++G P GV GP I DK+L EGA + GGG Sbjct: 337 EFVSGLKVEAERLVVGYPDQDGVNMGPLISHGHRDKVLSYYRLAVDEGATVVTGGGVPKF 396 Query: 377 ----NKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGV 432 ++G +VQPT+++ ++D+ R EEIFGPV I F D+VI R N++ YGL+ + Sbjct: 397 NDERDQGAYVQPTIWTGLSDKARCVTEEIFGPVCHISPFDDEDEVINRVNDSNYGLACAI 456 Query: 433 FTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492 +T ++ +A +S + G VWVN + + + PFGG K+SG GRE G + Y+++ + Sbjct: 457 WTTNLSRAHRVSRQIHVGLVWVNTWYLRDLRTPFGGVKLSGLGREGGRFSMDFYSDIANI 516 Query: 493 TVKI 496 +KI Sbjct: 517 CIKI 520 >5J77-A nrPDB Length = 508 Score = 527 bits (1359), Expect = e-150, Method: Composition-based stats. Identities = 169/485 (34%), Positives = 268/485 (55%), Gaps = 13/485 (2%) Query: 21 TKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80 TK++I+ +W +S SGK ++P T + + ++E ++DVD+A+ AA AF W + Sbjct: 3 TKLYIDGQWVNSSSGKTVDKYSPVTGQVIGRMEAATRDDVDRAIDAAEDAFWA---WNDL 59 Query: 81 DASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI 140 + ER +++Y+ +LIE++R L + GK A ++ G I ++Y A WA K+ Sbjct: 60 GSVERSKIIYRAKELIEKNRAELENIIMEENGKPVKEAK-EEVDGVIDQIQYYAEWARKL 118 Query: 141 QGRTIPIDGNFFTYTRHE-PIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP 199 G + + +++ P G+ + PWNFP M+ K+ PAL GNTVV+KP+ TP Sbjct: 119 NGEVVEGTSSHRKIFQYKVPYGIVVALTPWNFPAGMVARKLAPALLTGNTVVLKPSSDTP 178 Query: 200 LTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAG 259 +A + EAG P GV+N + G G G I H ++ + TGST G+ I + A Sbjct: 179 GSAEWIVRKFVEAGVPKGVLNFITGRGSEIGDYIVEHKKVNLITMTGSTATGQRIMQKAS 238 Query: 260 KSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEF 319 +N+ ++ LELGGK+P +V DAD+DNA++ +++ GQ CIAA R++V E IYD F Sbjct: 239 -ANMAKLILELGGKAPFMVWKDADMDNALKTLLWAKYWNAGQSCIAAERLYVHEDIYDTF 297 Query: 320 VRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG--- 376 + R VE ++K LG+P GP I+K +++E K+ GAK+ GG Sbjct: 298 MSRFVELSRKLALGDP--KNADMGPLINKGALQATSEIVEEAKESGAKILFGGSQPSLSG 355 Query: 377 --NKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFT 434 GYF PT+ N + +I +EEIF PV K S++++ AN+ YGL++ +FT Sbjct: 356 PYRNGYFFLPTIIGNADQKSKIFQEEIFAPVIGARKISSVEEMYDLANDNKYGLASYLFT 415 Query: 435 KDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTV 494 KD + S ++ G ++VN G ++Q GF+M+G E +YG EY ++K + V Sbjct: 416 KDPNIIFEASERIRFGELYVNMPGPEASQGYHTGFRMTGQAGEGSKYGISEYLKLKNIYV 475 Query: 495 KISQK 499 S K Sbjct: 476 DYSGK 480 >3EK1-A nrPDB Length = 504 Score = 527 bits (1359), Expect = e-150, Method: Composition-based stats. Identities = 178/493 (36%), Positives = 269/493 (54%), Gaps = 8/493 (1%) Query: 7 PDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKA 66 P + L D + ++ +N W D+ G V NPA + V + +A+ A Sbjct: 19 PGSMLALKDPSLLKSQCLVNGRWIDAADGTTIKVTNPADGSVIGTVPSLSVATIKEAIDA 78 Query: 67 ARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGC 126 + +A S W A ER +L K DLI + +A + + GK + A ++ Sbjct: 79 SAKAL---SGWAAKTAKERAGILRKWFDLIIANADDIALIMTSEQGKPLAEAR-GEVLYA 134 Query: 127 IKTLRYCAGWADKIQGRTIPIDGNFFTYTR-HEPIGVCGQIIPWNFPLVMLIWKIGPALS 185 + + A A ++ G TIP N T +P+GV I PWNFP M+ K PAL+ Sbjct: 135 ASFIEWFAEEAKRVYGDTIPAPQNGQRLTVIRQPVGVTAAITPWNFPAAMITRKAAPALA 194 Query: 186 CGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFT 245 G T++V+PA+ TPLTAL + L ++AG P GV+ IV G GA ++S+ + K++FT Sbjct: 195 AGCTMIVRPADLTPLTALALGVLAEKAGIPAGVLQIVTGKAREIGAELTSNDTVRKLSFT 254 Query: 246 GSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIA 305 GSTEVG+L+ +KR++LELGG +P IV DADLD AV+ A + + GQ C+ Sbjct: 255 GSTEVGRLLMAQCA-PTIKRISLELGGNAPFIVFDDADLDAAVDGAMVSKYRNAGQTCVC 313 Query: 306 ASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEG 365 A+RI+V+ +YD+F + + K+ +GN PGV GP I+++ K+ IE +G Sbjct: 314 ANRIYVQRGVYDKFAEKLAAKVKELKVGNGTEPGVVIGPMIEEKAITKVKAHIEDAVSKG 373 Query: 366 AKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTF 425 AKL GG G G F +P + + VT +M +AKEE FGP+ + F + ++VI +AN+T Sbjct: 374 AKLITGGKELG--GLFFEPGILTGVTSDMLVAKEETFGPLAPLFAFDTEEEVIAQANDTI 431 Query: 426 YGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHE 485 +GL+A +T++ +AI +S AL+ G V N + + PFGG K SG GRE +YG E Sbjct: 432 FGLAAYFYTENFSRAIRVSEALEYGMVGHNTGLISNEVAPFGGVKQSGLGREGSKYGIEE 491 Query: 486 YTEVKTVTVKISQ 498 Y E K + + Sbjct: 492 YLETKYICSAYKR 504 >1WNB-A nrPDB Length = 495 Score = 527 bits (1357), Expect = e-150, Method: Composition-based stats. Identities = 175/490 (35%), Positives = 262/490 (53%), Gaps = 8/490 (1%) Query: 8 DLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAA 67 + L + K+ IN E G+K PV+NPAT + L ++ E E VD AV+AA Sbjct: 11 ESTSLYKKAGLMQHKLLINGELVSG-EGEKQPVYNPATGDVLLEIAEASAEQVDAAVRAA 69 Query: 68 RQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCI 127 + W R L KLAD+IE + + A +ES N GK +A+ +++ + Sbjct: 70 D---AAFAEWGQTTPKVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIV 126 Query: 128 KTLRYCAGWADKIQGRTIPID-GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSC 186 R+ AG A + G + R +P+GV I PWN+PL+M WK+ PAL+ Sbjct: 127 DVFRFFAGAARCLNGLAAGEYLEGHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAA 186 Query: 187 GNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTG 246 GN VV+KP+E TPLTAL +A L K+ FP GVVNI+ G G T G ++ H + V+ TG Sbjct: 187 GNCVVLKPSEITPLTALKLAELAKDI-FPAGVVNILFGRGKTVGDPLTGHPKVRMVSLTG 245 Query: 247 STEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAA 306 S G+ I S++KR +ELGGK+P IV DAD++ VE +Y+ GQ C AA Sbjct: 246 SIATGEHIISHTA-SSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAA 304 Query: 307 SRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEG- 365 RI+ ++ IYD V + G P GP +++ +E K G Sbjct: 305 CRIYAQKGIYDTLVEKLGAAVATLKSGAPDDESTELGPLSSLAHLERVGKAVEEAKATGH 364 Query: 366 AKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTF 425 K+ GG GY+ PT+ + + I ++E+FGPV + F + + V+ AN++ Sbjct: 365 IKVITGGEKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQ 424 Query: 426 YGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHE 485 YGL++ V+TKD+ +A +S+ LQ G WVN + ++ ++ P GG K+SG G+++ YG + Sbjct: 425 YGLASSVWTKDVGRAHRVSARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSLYGLED 484 Query: 486 YTEVKTVTVK 495 YT V+ V VK Sbjct: 485 YTVVRHVMVK 494 >6C43-A nrPDB Length = 477 Score = 522 bits (1344), Expect = e-148, Method: Composition-based stats. Identities = 171/476 (35%), Positives = 252/476 (52%), Gaps = 8/476 (1%) Query: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 ++ IN D G++ V+NPAT E + ++ E VD AV+AA AF + W Sbjct: 7 QLLINGVLVDG-EGERQSVYNPATGEVILEIAEASPAQVDAAVQAADNAF---AEWGQTT 62 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 R L KLAD IE++ L A +ES N GK +++ + R+ AG A + Sbjct: 63 PKARAECLLKLADSIEQNALEFARLESQNCGKPLHCVINDEIPAIVDVFRFFAGAARCLS 122 Query: 142 GRTIPID-GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200 G + R +PIGV I PWN+PL+M WK+ PAL+ GN VV+KP+E TPL Sbjct: 123 GLAAGEYLEGHTSMIRRDPIGVVASIAPWNYPLMMAAWKLAPALAAGNCVVIKPSEITPL 182 Query: 201 TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGK 260 TAL +A L K+ FPPGV+N++ G G T G ++ H + V+ TGS G+ I Sbjct: 183 TALKLAVLAKDI-FPPGVLNVLFGRGQTVGDVLTGHEKVRMVSLTGSIATGEHILRHTA- 240 Query: 261 SNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFV 320 +KR +ELGGK+P IV DADLD + FY+ GQ C AA RI+ + IYD V Sbjct: 241 PAIKRTHMELGGKAPVIVFDDADLDAVAQGVRTFGFYNAGQDCTAACRIYAQRGIYDALV 300 Query: 321 RRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKK-EGAKLECGGGPWGNKG 379 + +G P GP ++ +E K ++ GG KG Sbjct: 301 EKLGNAVSSLKMGAPEDESTELGPLSSLAHLKRVTAAVEEAKALSHIRVITGGSQTEGKG 360 Query: 380 YFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDK 439 Y+ PT+ ++ E I + E+FGPV I F D V++ AN++ YGL++ V+T+D+ + Sbjct: 361 YYFAPTLLADAKQEDAIVQREVFGPVVSITVFDDEDQVLRWANDSRYGLASSVWTQDVGR 420 Query: 440 AITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495 A +S+ LQ G W+N + ++ ++ P GG K SG G+++ YG +YT V+ + VK Sbjct: 421 AHRLSARLQYGCTWINTHFMLVSEMPHGGQKQSGYGKDMSLYGLEDYTLVRHIMVK 476 >3TY7-A nrPDB Length = 478 Score = 520 bits (1340), Expect = e-148, Method: Composition-based stats. Identities = 179/476 (37%), Positives = 255/476 (53%), Gaps = 12/476 (2%) Query: 20 YTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRT 79 YTK +IN EW +S S + V NPATEE + +V +G+K DVDKAV+AA + +R Sbjct: 7 YTKQYINGEWVESNSNETIEVINPATEEVIGKVAKGNKADVDKAVEAADDVYL---EFRH 63 Query: 80 MDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADK 139 ER LL K+ E + + + G S + + D Sbjct: 64 TSVKERQALLDKIVKEYENRKDDIVQAITDELGAPLSLSERVHYQMGLNHFVAARDALDN 123 Query: 140 IQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP 199 + + E IGV G I PWNFP K+ A + G+ VV+KP+E+TP Sbjct: 124 YEFE----ERRGDDLVVKEAIGVSGLITPWNFPTNQTSLKLAAAFAAGSPVVLKPSEETP 179 Query: 200 LTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAG 259 A+ +A + + G P GV N+V G G G +S H + ++FTGS G I E A Sbjct: 180 FAAVILAEIFDKVGVPKGVFNLVNGDGAGVGNPLSEHPKVRMMSFTGSGPTGSKIMEKAA 239 Query: 260 KSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEF 319 K + K+V+LELGGKSP IVL D D+ A + V + GQ C A +R+ V I D F Sbjct: 240 K-DFKKVSLELGGKSPYIVLDDVDIKEAAKATTGKVVNNTGQVCTAGTRVLVPNKIKDAF 298 Query: 320 VRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGG---GPWG 376 + E+ + +GNP G GP I K+Q+D++ + I G +EGA+L GG Sbjct: 299 LAELKEQFSQVRVGNPREDGTQVGPIISKKQFDQVQNYINKGIEEGAELFYGGPGKPEGL 358 Query: 377 NKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKD 436 KGYF +PT+F NV ++M IA+EEIFGPV ++ + LD+ I+ AN+T YGL+ V KD Sbjct: 359 EKGYFARPTIFINVDNQMTIAQEEIFGPVMSVITYNDLDEAIQIANDTKYGLAGYVIGKD 418 Query: 437 IDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492 + ++ +++AGTV +N G PFGG+K SG GRE G+YG E+ EVK++ Sbjct: 419 KETLHKVARSIEAGTVEINEAG-RKPDLPFGGYKQSGLGREWGDYGIEEFLEVKSI 473 >4LIH-A nrPDB Length = 504 Score = 519 bits (1336), Expect = e-147, Method: Composition-based stats. Identities = 203/501 (40%), Positives = 297/501 (59%), Gaps = 9/501 (1%) Query: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60 M+ D L+I+ + FI+ D+ G+ F +P L +V + + DV Sbjct: 9 MNKLTLADWQHKAASLEIEG-RAFIDGASRDAHGGRTFDCVSPIDGRVLAKVADCGEADV 67 Query: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120 + AV AAR+AF G W ++ R +L + A L+ L+ +E+++ GK + Sbjct: 68 NAAVAAARRAFDAGV-WAGLNPRARKAVLLRWAALMREHLDELSLLETLDAGKPIGDTTT 126 Query: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180 D+ G + + A DK+ G P D + EP+GV ++PWNFP++M WK Sbjct: 127 VDVPGAAYCVEWFAEAIDKVGGEVAPADHHLVGLVTREPVGVVAAVVPWNFPILMAAWKF 186 Query: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240 GPAL+ GN+VV+KP+E++PLTA+ VA L EAG P GV N+VPG G G ++ H D+D Sbjct: 187 GPALAAGNSVVLKPSEKSPLTAIRVAQLAFEAGIPAGVFNVVPGAG-EPGKLLALHRDVD 245 Query: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADA-DLDNAVEFAHHGVFYHQ 299 +AFTGST VGKLI + A +SNLKR LELGGKSP IVL D DLD A + A +FY+ Sbjct: 246 CIAFTGSTAVGKLIMQYAAQSNLKRAWLELGGKSPNIVLPDCPDLDRAAQTAAGAIFYNM 305 Query: 300 GQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIE 359 G+ C A SR+ V I D F+ + V A+ Y+ GNPL P V+ G +D Q +++L IE Sbjct: 306 GEMCTAGSRLLVHRDIKDAFIEKLVAAARAYVPGNPLDPSVSMGAIVDGIQLERVLGYIE 365 Query: 360 SGKKEGAKLECGGGPWGNK--GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDV 417 +G+ EG +L GG + G++V+PTVF V + +IA+EEIFGPV ++ F +D+ Sbjct: 366 AGRGEG-RLVTGGARVNAETGGFYVEPTVFE-VKPDAKIAREEIFGPVLSVIVFDDVDEA 423 Query: 418 IKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYG-VVSAQCPFGGFKMSGNGR 476 ++ AN+T YGL+A V+T ++ A +S L+AGTVWVNCY PFGG+K SGNGR Sbjct: 424 VRIANDTEYGLAAAVWTSNLTTAHDVSRRLRAGTVWVNCYDEGGDMNFPFGGYKQSGNGR 483 Query: 477 ELGEYGFHEYTEVKTVTVKIS 497 + + +YTE+K+ +++ Sbjct: 484 DKSLHALEKYTELKSTLIRLR 504 >3I44-A nrPDB Length = 497 Score = 515 bits (1327), Expect = e-146, Method: Composition-based stats. Identities = 178/478 (37%), Positives = 267/478 (55%), Gaps = 9/478 (1%) Query: 18 IQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPW 77 + K +IN W D + V +P+TEE + G D DKA+ AA++AFQ W Sbjct: 23 LNKRKFYINGLWDDPSTPHDLYVIDPSTEEACAVISLGSTRDADKAINAAKKAFQT---W 79 Query: 78 RTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWA 137 +T ER + K+ ++ E+ +A SM G A A +R Sbjct: 80 KTTSPHERLGFVEKILEIYEKRSSDMAKTISMEMGAPIDMALNAQTATGSSHIRNFIKAY 139 Query: 138 DKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQ 197 + + I+GN ++ IGV G I PWN+P+ + K+ PAL G T+V+KP+E Sbjct: 140 KEFSFQEALIEGNEQAILHYDAIGVVGLITPWNWPMNQVTLKVIPALLAGCTMVLKPSEI 199 Query: 198 TPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEA 257 PL+A+ A ++ EA P GV N++ G G G+ +S+H D++ ++FTGST GK I + Sbjct: 200 APLSAMLFAEILDEAALPSGVFNLINGDGANVGSYLSAHPDLEMISFTGSTRAGKDISKN 259 Query: 258 AGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYD 317 A + LKRV LELGGK I+ ADAD+D A++ FY+ GQ C A +R+ VE++IYD Sbjct: 260 AS-NTLKRVCLELGGKGANIIFADADID-ALQRGVRHCFYNSGQSCNAPTRMLVEQAIYD 317 Query: 318 EFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG- 376 + ++ + + A+K +G G GP + KEQYDKI DLI+SG EGA L GG Sbjct: 318 KAIKTAKDIAEKTQVGPGHQTGNHIGPVVSKEQYDKIQDLIQSGIDEGATLVTGGTGLPM 377 Query: 377 --NKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFT 434 +GY+V+PTVF++V MRI +EEIFGPV ++ F + D+ + AN+T YGL+ + + Sbjct: 378 GMERGYYVRPTVFADVKPHMRIFREEIFGPVLSLLPFNTEDEAVTLANDTEYGLTNYIQS 437 Query: 435 KDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492 +D K I++ +++G V VN + + FGG K SG RE G +G E+ + K + Sbjct: 438 QDRSKCRRIAAQVRSGMVEVNGHELPGGSY-FGGVKFSGRAREGGLWGIKEFLDTKAI 494 >4U3W-A nrPDB Length = 505 Score = 513 bits (1321), Expect = e-146, Method: Composition-based stats. Identities = 178/489 (36%), Positives = 260/489 (53%), Gaps = 15/489 (3%) Query: 19 QYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWR 78 Q + +IN E+ SG FP +P +L V E D VD AV+AA A + G WR Sbjct: 22 QLLRHYINGEFV--ASGTTFPNLSPVDGRKLADVCEADAALVDSAVQAAHAAQKAG--WR 77 Query: 79 TMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWAD 138 ++R L+K+AD IE E + G+ + A D+A I R A Sbjct: 78 DTTPAQRAAWLHKIADGIEARFDEFVAAEVADTGRPVAQARTLDIARGIANFRTFADLVR 137 Query: 139 KIQGR---TIPIDGNFF-TYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKP 194 G T DG+ Y +P+GV G I PWN PL++ WK+ PAL+ GN VV KP Sbjct: 138 TASGEYFETHAADGSELINYVTRKPLGVIGIISPWNLPLLLFTWKVAPALAMGNCVVAKP 197 Query: 195 AEQTPLTALHVASLIKEAGFPPGVVNIVPGYGP-TAGAAISSHMDIDKVAFTGSTEVGKL 253 +E+TP +A +A ++ + G PPGV N++ G+G AG ++ H DI + FTG + G Sbjct: 198 SEETPSSATLLAEVMHDVGLPPGVFNLIHGHGQNAAGEFLTRHPDISAITFTGESRTGST 257 Query: 254 IKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEE 313 I +A +K V+ ELGGK+ +V ADAD D AV F + GQ C+ + R++VE Sbjct: 258 IMKAVA-DGVKEVSFELGGKNAAVVFADADFDAAVAGVLRSSFTNAGQVCLCSERVYVER 316 Query: 314 SIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG 373 I++ FV E+A+ +G P P T GP I + DK+L +EGA + GGG Sbjct: 317 PIFERFVAALKEQAQALRVGAPEDPATTMGPLISRGHRDKVLSYFRLAVEEGATVVTGGG 376 Query: 374 PWG-----NKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGL 428 + G FV PT+++ + D R +EEIFGPV I F +V+KR N++ YGL Sbjct: 377 APSFGDARDDGAFVMPTIWTGLPDSARCVREEIFGPVCHIAPFDDEAEVVKRVNDSAYGL 436 Query: 429 SAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTE 488 +A ++T + + ++ ++ G VWVN + V + PFGG K+SG GRE G + Y+E Sbjct: 437 AASIWTTQLARGHRVAKQIETGIVWVNAWFVRDLRTPFGGTKLSGLGREGGRHSLDFYSE 496 Query: 489 VKTVTVKIS 497 + V V+I+ Sbjct: 497 LTNVCVRIA 505 >4F3X-A nrPDB Length = 498 Score = 509 bits (1311), Expect = e-144, Method: Composition-based stats. Identities = 169/486 (34%), Positives = 257/486 (52%), Gaps = 14/486 (2%) Query: 17 KIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSP 76 + T++ I + + ++ + NP T + + E +D AV AA +AF Sbjct: 22 SMMDTQLLIGSRFEAGTEAEEH-ILNPRTGAGIIDLAEASHAQIDAAVDAAERAF---VG 77 Query: 77 WRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGW 136 W +ER L K+AD IE++ A +E++N GK + ++L I R+ AG Sbjct: 78 WSQTTPAERSNALLKIADAIEKEADEFAALEALNCGKPINAVKNDELPAIIDCWRFFAGA 137 Query: 137 ADKIQ----GRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVV 192 + G +P + R +PIG+ G I PWN+PL+M+ WK+ PA+ GNTVV Sbjct: 138 VRNLHAPAAGEYLP---GHTSMIRRDPIGIVGSIAPWNYPLMMMAWKLAPAIGGGNTVVF 194 Query: 193 KPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGK 252 KP+EQTPLTAL +A LI + P GVVN++ G G T G A+ +H + V+ TG GK Sbjct: 195 KPSEQTPLTALKLARLIADI-LPEGVVNVITGRGETVGNALINHPKVGMVSITGDIATGK 253 Query: 253 LIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVE 312 + AA K+ +KR LELGGK+P IV DADL+ V +Y+ GQ C AA RI+ E Sbjct: 254 KVLAAAAKT-VKRTHLELGGKAPVIVYGDADLEAVVNGIRTFGYYNAGQDCTAACRIYAE 312 Query: 313 ESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKE-GAKLECG 371 IY++ V GP I + Q D++ +E + ++ G Sbjct: 313 AGIYEKLVADLTSAVSTIRYNLDDDTENEIGPLISRRQRDRVASFVERAADQKHIEITTG 372 Query: 372 GGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAG 431 G ++G+F QPTV + T E I + E+FGPV + +F DD + AN++ YGL++ Sbjct: 373 GRTGSDEGFFFQPTVVAGATQEDEIVRREVFGPVVSVTRFTGKDDAVAWANDSDYGLASS 432 Query: 432 VFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKT 491 V+TKDI KA+ +S LQ G W+N + +++ + P GG K SG G+++ Y +YT V+ Sbjct: 433 VWTKDISKAMRAASRLQYGCTWINTHFMLTNEMPHGGIKQSGYGKDMSVYALEDYTAVRH 492 Query: 492 VTVKIS 497 + + Sbjct: 493 IMINHG 498 >3U4J-A nrPDB Length = 528 Score = 508 bits (1310), Expect = e-144, Method: Composition-based stats. Identities = 195/501 (38%), Positives = 290/501 (57%), Gaps = 7/501 (1%) Query: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPAT-EEELCQVEEGDKED 59 +S+ PD +K +Y ++ ++ + D+ SG +P E + E +D Sbjct: 4 LSNFIAPDSNDPRLRIKSRY-QMLVDGKSVDAASGSTIDRVSPGHAGEVVGTWPEASADD 62 Query: 60 VDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAY 119 V KAV AAR+AF G PW M +ER RL++K+ADLI + LA +ES+ GK + A Sbjct: 63 VRKAVAAARKAFDAG-PWPRMSGAERSRLMFKVADLILARQEELALIESLEVGKPIAQAR 121 Query: 120 LNDLAGCIKTLRYCAGWADKIQGRTIP-IDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIW 178 ++ C Y AG A ++G+T I + EP+GV G I PWNFP ++ Sbjct: 122 -GEIGFCADLWSYAAGQARALEGQTHNNIGDDRLGLVLREPVGVVGIITPWNFPFIIASE 180 Query: 179 KIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMD 238 ++ A+ G TVV+KP+E T T++ +A L +EAG P GV N+V GYG AG ++ + Sbjct: 181 RVPWAIGSGCTVVLKPSEFTSGTSIRLAELAREAGIPDGVFNVVTGYGDPAGQVLAEDPN 240 Query: 239 IDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYH 298 +D VAFTGS VG + E A ++ +KRV LELGGK P IV ADADLD A + +GV+++ Sbjct: 241 VDMVAFTGSVRVGTKLGEIAART-VKRVGLELGGKGPQIVFADADLDAAADGIAYGVYHN 299 Query: 299 QGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLI 358 GQCCI+ SR+ V+E I D + R ++ ++K G+PL G I + +K+ + Sbjct: 300 AGQCCISGSRLLVQEGIRDALMERLLDISRKVAFGDPLNERTKIGAMISEAHAEKVHSYV 359 Query: 359 ESGKKEGAKLECGGGPWGNK-GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDV 417 +G GA+L GG G + G + PTVF+ VT +M IA+EEIFGPV + FK+ D+ Sbjct: 360 TAGITSGAELLLGGERIGREAGLYYAPTVFAGVTPDMSIAREEIFGPVLSTLTFKTADEA 419 Query: 418 IKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRE 477 + AN T +GLSA V++ +++ A+ ++AG W+N + + P GG+K SG GRE Sbjct: 420 VALANATEFGLSASVWSTNLETALQTIRRIRAGRCWINSVIDGTPELPIGGYKKSGLGRE 479 Query: 478 LGEYGFHEYTEVKTVTVKISQ 498 LG YGF EY++ K V V + + Sbjct: 480 LGRYGFDEYSQFKGVHVTLGR 500 >3K2W-A nrPDB Length = 497 Score = 508 bits (1309), Expect = e-144, Method: Composition-based stats. Identities = 157/492 (31%), Positives = 249/492 (50%), Gaps = 10/492 (2%) Query: 9 LPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAAR 68 + + + DL + FI ++ S + +P+T + + ++ G K D + A++ A+ Sbjct: 1 MSLTVQDLHFKNKVNFIGGQYVPSNESDTIDILSPSTGKVIGEIPAGCKADAENALEVAQ 60 Query: 69 QAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIK 128 A + + + A R +L A+ I ++ +LA M GKL S A + ++ Sbjct: 61 AAQKAWAK---LTARTRQNMLRTFANKIRENKHILAPMLVAEQGKLLSVAEM-EVDVTAT 116 Query: 129 TLRYCAGWADKIQGRTIPID-GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCG 187 + Y A I+G +P D + Y P GV I WNFPL + KIGPAL G Sbjct: 117 FIDYGCDNALTIEGDILPSDNQDEKIYIHKVPRGVVVGITAWNFPLALAGRKIGPALITG 176 Query: 188 NTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGS 247 NT+V+KP ++TPL + + KEAG P GV+N++ G G G + + TGS Sbjct: 177 NTMVLKPTQETPLATTELGRIAKEAGLPDGVLNVINGTGSVVGQTLCESPITKMITMTGS 236 Query: 248 TEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAAS 307 T GK I + + + + V LELGGK+P +V+ DADLD A E A G F + GQ C Sbjct: 237 TVAGKQIYKTSAEY-MTPVMLELGGKAPMVVMDDADLDKAAEDALWGRFANCGQVCTCVE 295 Query: 308 RIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAK 367 R++V S+YDEF+ + + K +G+P+ GP+ ++ + D I ++ K+GA Sbjct: 296 RLYVHASVYDEFMAKFLPLVKGLKVGDPMDADSQMGPKCNQREIDNIDHIVHEAIKQGAT 355 Query: 368 LECGGGPWGNKGY----FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANN 423 + GG +G+ + +PTV +V + + EE FGP+ I+K S++ I+ N+ Sbjct: 356 VATGGKTATVEGFEGGCWYEPTVLVDVKQDNIVVHEETFGPILPIVKVSSMEQAIEFCND 415 Query: 424 TFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGF 483 + YGLSA V T+ S L+ G V++N Q G+K SG G E G++G Sbjct: 416 SIYGLSAYVHTQSFANINQAISDLEVGEVYINRGMGEQHQGFHNGWKQSGFGGEDGKFGL 475 Query: 484 HEYTEVKTVTVK 495 +Y E KTV + Sbjct: 476 EQYLEKKTVYIN 487 >2HG2-A nrPDB Length = 479 Score = 508 bits (1309), Expect = e-144, Method: Composition-based stats. Identities = 157/475 (33%), Positives = 251/475 (52%), Gaps = 7/475 (1%) Query: 23 IFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDA 82 ++I+ ++ V NPATE + ++ +G ED KA+ AA +A W + A Sbjct: 9 MYIDGQFVTWRGDAWIDVVNPATEAVISRIPDGQAEDARKAIDAAERAQ---PEWEALPA 65 Query: 83 SERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQG 142 ER L K++ I ++ + GGK+ A + ++A + Y A WA + +G Sbjct: 66 IERASWLRKISAGIRERASEISALIVEEGGKIQQLAEV-EVAFTADYIDYMAEWARRYEG 124 Query: 143 RTIPIDGNFFTYTR-HEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLT 201 I D +GV I+PWNFP ++ K+ PAL GNT+V+KP+E TP Sbjct: 125 EIIQSDRPGENILLFKRALGVTTGILPWNFPFFLIARKMAPALLTGNTIVIKPSEFTPNN 184 Query: 202 ALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKS 261 A+ A ++ E G P GV N+V G G T G ++ + + V+ TGS G+ I A K Sbjct: 185 AIAFAKIVDEIGLPRGVFNLVLGRGETVGQELAGNPKVAMVSMTGSVSAGEKIMATAAK- 243 Query: 262 NLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVR 321 N+ +V LELGGK+P IV+ DADL+ AV+ + GQ C A R++V++ IYD+FV Sbjct: 244 NITKVCLELGGKAPAIVMDDADLELAVKAIVDSRVINSGQVCNCAERVYVQKGIYDQFVN 303 Query: 322 RSVERAKKYILGNPLTP-GVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGY 380 R E + GNP + GP I+ +++ + +EGA++ GG KGY Sbjct: 304 RLGEAMQAVQFGNPAERNDIAMGPLINAAALERVEQKVARAVEEGARVAFGGKAVEGKGY 363 Query: 381 FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKA 440 + PT+ +V EM I EE FGPV ++ F +L+D I AN++ YGL++ ++T++++ A Sbjct: 364 YYPPTLLLDVRQEMSIMHEETFGPVLPVVAFDTLEDAISMANDSDYGLTSSIYTQNLNVA 423 Query: 441 ITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495 + L+ G ++N + Q G++ SG G G++G HEY + + V ++ Sbjct: 424 MKAIKGLKFGETYINRENFEAMQGFHAGWRKSGIGGADGKHGLHEYLQTQVVYLQ 478 >5EUY-A nrPDB Length = 491 Score = 505 bits (1300), Expect = e-143, Method: Composition-based stats. Identities = 163/491 (33%), Positives = 256/491 (52%), Gaps = 11/491 (2%) Query: 13 LTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQ 72 + DL I +IN E+ + +G +P ++ +V +ED +A+ +A +A + Sbjct: 1 MIDLNIMKVANYINGEFKEPSTGAFQVKTSPVDGSKIAEVPRSGREDAREAIDSAFEALK 60 Query: 73 IGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRY 132 W + A R LYK+ ++ + + + ++ GG Y + ++ + ++ Sbjct: 61 A---WANIPAIRRAEYLYKMLEVFRQMKEDFMKILTVEGGGTYRKVW-GEVVFTERLIQN 116 Query: 133 CAGWADKIQGRTIPIDG-NFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVV 191 A A QGR + D + + GV G I PWN+PL + + KI L+ GNTVV Sbjct: 117 AAELARHYQGRVLQSDSESTISVVFKRSKGVVGVITPWNYPLSISMKKIAHTLAVGNTVV 176 Query: 192 VKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVG 251 KPA TP+T +A ++ +AG P GV N+V G GP G I +H + V FTG + G Sbjct: 177 YKPASDTPVTGWLIAQMVAKAGLPKGVFNLVIGPGPVVGEEIVTHKRVAHVTFTGESSTG 236 Query: 252 KLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFV 311 + I A + LK VTLELGG P I+L D D+D A A +HQGQ C +A RI V Sbjct: 237 REIAAKAAGT-LKTVTLELGGSDPLIILDDVDVDYAARLAVFASLFHQGQICTSAKRIIV 295 Query: 312 EESIYDEFVRRSVERAKKYILGNPL-TPGVTQGPQIDKEQYDKILDLIESGKKEGAKLEC 370 +++ D+F+ R V K + +P V GP I++ Q + + ++ G +L Sbjct: 296 HKAVADKFIERYVHYVKMLRIDDPRKDEKVDLGPLINERQVALMKEFVDDAVSRGGRLLI 355 Query: 371 GGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSA 430 GG W G F +P +F +V RI +EE+FGPV+ I+ ++ D ++ AN+T YGLS Sbjct: 356 GGRSW---GNFFEPAIFVDVDRNFRIMREEVFGPVRPIVVVENDDQAVEVANDTDYGLSG 412 Query: 431 GVFTKDIDKAITISSALQAGTVWVNCYGVV-SAQCPFGGFKMSGNGRELGEYGFHEYTEV 489 V T ++++A I+ A+++G +N + + PFGG K SG GRE GE+ FHE T Sbjct: 413 AVLTNNVNRAFRIAEAVESGMFHINDVTFLEESHVPFGGIKASGVGREGGEWSFHETTYD 472 Query: 490 KTVTVKISQKN 500 + VTV + + Sbjct: 473 RWVTVTLRTRR 483 >1T90-A nrPDB Length = 486 Score = 498 bits (1284), Expect = e-141, Method: Composition-based stats. Identities = 166/489 (33%), Positives = 254/489 (51%), Gaps = 11/489 (2%) Query: 17 KIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSP 76 +I+ K +IN EW +S + + V NPAT+E LCQV KED+D A + A +AF+ Sbjct: 2 EIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKEDIDYAAQTAAEAFKT--- 58 Query: 77 WRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGW 136 W + R R+L+ L+ + + LA + ++ GK A L ++ I+ + + AG Sbjct: 59 WSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEA-LGEVGRGIENVEFAAGA 117 Query: 137 ADKIQGRTIP-IDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPA 195 + G ++ I + PIGV G I P+NFP+++ W A++ GNT ++KP+ Sbjct: 118 PSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPCWMFPMAIALGNTFILKPS 177 Query: 196 EQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIK 255 E+TPL + L ++AG P GV N+V G + H +I ++F GS VG+ + Sbjct: 178 ERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGIL-EHPEIKAISFVGSKPVGEYVY 236 Query: 256 EAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESI 315 + G NLKRV G K+ IVL DA+L++ V F G+ C+A + + VEE I Sbjct: 237 KK-GSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAAFGSAGERCMACAVVTVEEGI 295 Query: 316 YDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGP- 374 DEF+ + E+ +GN L GV GP I ++ + L IE G +EGA+L C G Sbjct: 296 ADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKRTLSYIEKGLEEGARLVCDGREN 355 Query: 375 WGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFT 434 + GYFV PT+F NVT EM I K+EIF PV +++ K+L + I+ AN + + A +FT Sbjct: 356 VSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIRVKNLKEAIEIANKSEFANGACLFT 415 Query: 435 KDIDKAITISSALQAGTVWVN-CYGVVSAQCPFGGFKMS--GNGRELGEYGFHEYTEVKT 491 + + + AG + +N A PF G+K S G G+ YT K Sbjct: 416 SNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFSGWKSSFFGTLHANGKDSVDFYTRKKV 475 Query: 492 VTVKISQKN 500 VT + + Sbjct: 476 VTARYPAPD 484 >3B4W-A nrPDB Length = 495 Score = 498 bits (1284), Expect = e-141, Method: Composition-based stats. Identities = 180/487 (36%), Positives = 259/487 (53%), Gaps = 6/487 (1%) Query: 13 LTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQ 72 ++D +Y K+FI +W + V PAT E + +V DVD AV AAR AF Sbjct: 1 MSDSATEYDKLFIGGKWTKPSTSDVIEVRCPATGEYVGKVPMAAAADVDAAVAAARAAFD 60 Query: 73 IGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRY 132 G PW + ER ++ ++ + L + + G+ + G + + Y Sbjct: 61 NG-PWPSTPPHERAAVIAAAVKMLAERKDLFTKLLAAETGQPPTIIETMHWMGSMGAMNY 119 Query: 133 CAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVV 192 AG ADK+ + EP+GV G I+ WN PL + + KI PAL G T+V+ Sbjct: 120 FAGAADKVTWTETRTGSYGQSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVL 179 Query: 193 KPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGK 252 KPA +TPLTA +A + E G P GV+++VPG G G A++S+ DID FTGS+ VG+ Sbjct: 180 KPAAETPLTANALAEVFAEVGLPEGVLSVVPG-GIETGQALTSNPDIDMFTFTGSSAVGR 238 Query: 253 LIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVE 312 + A + LK TLELGGKS I+L D DL A+ + GQ C+ +RI Sbjct: 239 EVGRRAAEM-LKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQTRILAP 297 Query: 313 ESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGG 372 S YDE V +G P P GP I ++Q ++ I G +EGA+L CGG Sbjct: 298 RSRYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTRVEGYIAKGIEEGARLVCGG 357 Query: 373 GPWG--NKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSA 430 G + G+F+QPTVF++V ++M IA+EEIFGPV I+ + + +D I AN++ YGL+ Sbjct: 358 GRPEGLDNGFFIQPTVFADVDNKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAG 417 Query: 431 GVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVK 490 V+T D+ K I IS ++ GT +N Y PFGG+K SG GRE G G +T+ K Sbjct: 418 SVWTTDVPKGIKISQQIRTGTYGINWY-AFDPGSPFGGYKNSGIGRENGPEGVEHFTQQK 476 Query: 491 TVTVKIS 497 +V + + Sbjct: 477 SVLLPMG 483 >5X5U-A nrPDB Length = 505 Score = 490 bits (1263), Expect = e-139, Method: Composition-based stats. Identities = 160/481 (33%), Positives = 243/481 (50%), Gaps = 6/481 (1%) Query: 15 DLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIG 74 ++ T++ I+ EW D+ SGK V NPAT + + +V D+D+A+ AA+ F+ Sbjct: 27 NVTYTDTQLLIDGEWVDAASGKTIDVVNPATGKPIGRVAHAGIADLDRALAAAQSGFEA- 85 Query: 75 SPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCA 134 WR + A ER + K A L+ +A + + GK + A + ++ + + A Sbjct: 86 --WRKVPAHERAATMRKAAALVRERADAIAQLMTQEQGKPLTEARV-EVLSAADIIEWFA 142 Query: 135 GWADKIQGRTIPIDG-NFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVK 193 ++ GR +P EP+G PWNFP+ ++ K+ AL+ G + +VK Sbjct: 143 DEGRRVYGRIVPPRNLGAQQTVVKEPVGPVAAFTPWNFPVNQVVRKLSAALATGCSFLVK 202 Query: 194 PAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKL 253 E+TP + + +AG P GV+ +V G + + H I KV FTGST VGK Sbjct: 203 APEETPASPAALLRAFVDAGVPAGVIGLVYGDPAEISSYLIPHPVIRKVTFTGSTPVGKQ 262 Query: 254 IKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEE 313 + AG ++KR T+ELGG +P IV DAD+ AV+ A F + GQ CI+ +R V Sbjct: 263 LASLAGL-HMKRATMELGGHAPVIVAEDADVALAVKAAGGAKFRNAGQVCISPTRFLVHN 321 Query: 314 SIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG 373 SI DEF R V+ A+ +GN L G T G + + + +I++ +K GA +E GG Sbjct: 322 SIRDEFTRALVKHAEGLKVGNGLEEGTTLGALANPRRLTAMASVIDNARKVGASIETGGE 381 Query: 374 PWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVF 433 G++G F PTV +NV + + E FGPV I F L++ I AN +GL+ F Sbjct: 382 RIGSEGNFFAPTVIANVPLDADVFNNEPFGPVAAIRGFDKLEEAIAEANRLPFGLAGYAF 441 Query: 434 TKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVT 493 T+ ++ L+ G +W+N + PFGG K SG G E G Y K+VT Sbjct: 442 TRSFANVHLLTQRLEVGMLWINQPATPWPEMPFGGVKDSGYGSEGGPEALEPYLVTKSVT 501 Query: 494 V 494 V Sbjct: 502 V 502 >3QAN-A nrPDB Length = 538 Score = 488 bits (1258), Expect = e-138, Method: Composition-based stats. Identities = 163/487 (33%), Positives = 247/487 (50%), Gaps = 17/487 (3%) Query: 23 IFINNEWHDSVSGKKFPVFNPA-TEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 + IN E + K +NPA ++ + V + +++ +KA+++A +AFQ WR ++ Sbjct: 40 LIINGERV--TTEDKIQSWNPARKDQLVGSVSKANQDLAEKAIQSADEAFQT---WRNVN 94 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 ER +L K A +I R + + GK + A D A I L Y A ++ Sbjct: 95 PEERANILVKAAAIIRRRKHEFSAWLVHEAGKPWKEAD-ADTAEAIDFLEYYARQMIELN 153 Query: 142 -GRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200 G+ I + P+GV I PWNF L +++ + GNTVV+KPA TP+ Sbjct: 154 RGKEILSRPGEQNRYFYTPMGVTVTISPWNFALAIMVGTAVAPIVTGNTVVLKPASTTPV 213 Query: 201 TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAG- 259 A ++++AG P GV+N VPG G G + H + FTGS +VG + E A Sbjct: 214 VAAKFVEVLEDAGLPKGVINYVPGSGAEVGDYLVDHPKTSLITFTGSKDVGVRLYERAAV 273 Query: 260 ----KSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESI 315 +++LKRV +E+GGK +V DADLD A E F GQ C A SR + + + Sbjct: 274 VRPGQNHLKRVIVEMGGKDTVVVDRDADLDLAAESILVSAFGFSGQKCSAGSRAVIHKDV 333 Query: 316 YDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPW 375 YDE + ++V AK +G+P GP ID++ ++KI+ IE GKKEG +L GG Sbjct: 334 YDEVLEKTVALAKNLTVGDPTNRDNYMGPVIDEKAFEKIMSYIEIGKKEG-RLMTGGEGD 392 Query: 376 GNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435 + G+F+QPT+ +++ E I +EEIFGPV K D ++ ANNT YGL+ V T+ Sbjct: 393 SSTGFFIQPTIIADLDPEAVIMQEEIFGPVVAFSKANDFDHALEIANNTEYGLTGAVITR 452 Query: 436 DIDKAITISSALQAGTVWV--NCYGVVSAQCPFGGFKMSGNGRE-LGEYGFHEYTEVKTV 492 + G ++ NC G + PFGGFKMSG + G + + KTV Sbjct: 453 NRAHIEQAKREFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQAKTV 512 Query: 493 TVKISQK 499 + ++ Sbjct: 513 SEMYAEN 519 >3RHD-A nrPDB Length = 486 Score = 487 bits (1254), Expect = e-138, Method: Composition-based stats. Identities = 154/477 (32%), Positives = 253/477 (53%), Gaps = 21/477 (4%) Query: 23 IFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDA 82 +FI+ +W + + V NP + E + ++ +E+ +A+ A + ++ + + Sbjct: 2 MFIDGKWI---NREDMDVINPYSLEVIKKIPALSREEAKEAIDTAEKYKEV---MKNLPI 55 Query: 83 SERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQG 142 ++R +L +A I+ + LA + +++ GK A + ++ I T + A + + + Sbjct: 56 TKRYNILMNIAKQIKEKKEELAKILAIDAGKPIKQARV-EVERSIGTFKLAAFYVKEHRD 114 Query: 143 RTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTA 202 IP D +TR EP+G+ G I P+NFPL + KI PA++ GN +V P+ + PL Sbjct: 115 EVIPSDDRLI-FTRREPVGIVGAITPFNFPLNLSAHKIAPAIATGNVIVHHPSSKAPLVC 173 Query: 203 LHVASLIKEA----GFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAA 258 + +A +I+ A P GV N++ G G G I + ++ ++FTGS++VG+LI + A Sbjct: 174 IELAKIIENALKKYNVPLGVYNLLTGAGEVVGDEIVVNEKVNMISFTGSSKVGELITKKA 233 Query: 259 GKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDE 318 G K++ LELGG +P IVL DADL+ AV G F + GQ CI+ I V+ESI D+ Sbjct: 234 G---FKKIALELGGVNPNIVLKDADLNKAVNALIKGSFIYAGQVCISVGMILVDESIADK 290 Query: 319 FVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNK 378 F+ V +AK +GNPL GP I E + + ++E EG KL GG Sbjct: 291 FIEMFVNKAKVLNVGNPLDEKTDVGPLISVEHAEWVEKVVEKAIDEGGKLLLGGKRDK-- 348 Query: 379 GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDID 438 PT+ V + + K E F PV I++ + +++I AN+T YGL + +FT DI+ Sbjct: 349 -ALFYPTILE-VDRDNILCKTETFAPVIPIIR-TNEEEMIDIANSTEYGLHSAIFTNDIN 405 Query: 439 KAITISSALQAGTVWVNCYGVVS-AQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTV 494 K++ + L+ G V +N + PFGG K SG GRE +Y E + +KT+ + Sbjct: 406 KSLKFAENLEFGGVVINDSSLFRQDNMPFGGVKKSGLGREGVKYAMEEMSNIKTIII 462 >4JZ6-A nrPDB Length = 500 Score = 485 bits (1250), Expect = e-137, Method: Composition-based stats. Identities = 179/483 (37%), Positives = 266/483 (55%), Gaps = 14/483 (2%) Query: 19 QYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWR 78 TK+FINN W DS + F +P + E + + D KA +AA +AF+ W+ Sbjct: 18 MKTKLFINNAWIDSSDQQTFERKHPVSSEVMTESANATVTDAIKAAQAAEEAFKT---WK 74 Query: 79 TMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWAD 138 + SER RLL K+AD++E + +M G A N + R A A Sbjct: 75 DVGPSERRRLLLKVADVMESKTPKFIEVMAMEVGASALWAGFN-VHASANVFREAASLAT 133 Query: 139 KIQGRTIPIDG-NFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQ 197 +IQG TIP D + T +P+G I+PWN V+ I L CGNTVV K +E Sbjct: 134 QIQGETIPTDKAETLSMTLRQPVGPILSIVPWNGTAVLAARAIAYPLVCGNTVVFKGSEF 193 Query: 198 TPLTALHVASLIKEAGFPPGVVNIVPGYG---PTAGAAISSHMDIDKVAFTGSTEVGKLI 254 +P T + ++EAG P GV+N + P A+ S +I ++ FTGST VG +I Sbjct: 194 SPATHALITQCVQEAGLPAGVLNYLNSSPDRSPEIADALISAKEIRRINFTGSTRVGSII 253 Query: 255 KEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEES 314 + A + +LKR LELGGKSP IVL DAD++ AV+ A G F QGQ C++ R+ V+E Sbjct: 254 AQKAAQ-HLKRCLLELGGKSPLIVLDDADINAAVKAAVFGSFLFQGQICMSTERLVVDEK 312 Query: 315 IYDEFVRRSVERAKKYILGNP-LTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG 373 I DEFV R VE+ ++ +G+P LT GP + ++I L + +GAK+ CGG Sbjct: 313 IADEFVARFVEKTERLSVGDPCLTGDCIIGPMVSPNSGERINGLFKDAIDKGAKVVCGGM 372 Query: 374 PWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVF 433 +G + T+ +V +MRI EE FGP+ +++ K + I+ AN++ YGLS+GVF Sbjct: 373 A---QGAVMPATILDHVKSDMRIYDEETFGPITVVIRCKGEAEAIRIANDSVYGLSSGVF 429 Query: 434 TKDIDKAITISSALQAGTVWVNCYGVVS-AQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492 +DI++A+ + +++ G V +N V + AQ P+GG K +G GR G E+TE+K + Sbjct: 430 GRDINRALRVGMSIEYGCVHINGSTVQNEAQAPYGGTKNTGYGRFDGRAVIDEFTELKWL 489 Query: 493 TVK 495 T++ Sbjct: 490 TIE 492 >4YWE-A nrPDB Length = 487 Score = 484 bits (1247), Expect = e-137, Method: Composition-based stats. Identities = 174/484 (35%), Positives = 263/484 (54%), Gaps = 9/484 (1%) Query: 18 IQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPW 77 ++ K FI EW + PV +P+ + + G D+++AV AAR PW Sbjct: 9 MEEAKHFIAGEWTLPAQLETIPVVDPSDGQPFATIARGTAPDIERAVAAARD--AFAGPW 66 Query: 78 RTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWA 137 A+ERGR+L +L+ + LA +E+ + GK A + A + + AG A Sbjct: 67 GAASAAERGRVLMRLSARVTDSIEELAAIEARDTGKPLKQARAD-AAALARYFEFYAGAA 125 Query: 138 DKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQ 197 DK+ G T+P + T EP GV G I+PWN+P+ + +G AL+ GN VVKPAE Sbjct: 126 DKLHGETLPYQAGYTVLTVREPHGVTGHIVPWNYPMQIFGRSVGAALAAGNACVVKPAED 185 Query: 198 TPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEA 257 L+ L VA L EAG P G +NIV GYG AGAA++ H ID ++FTGS GKL+ + Sbjct: 186 ACLSVLRVAELAAEAGLPAGALNIVTGYGHEAGAALARHPGIDHISFTGSPATGKLVTQM 245 Query: 258 AGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYD 317 A ++++ VTLELGGKSP IV ADADLD A+ + + GQ C A SR+ +E ++Y+ Sbjct: 246 AAENHV-PVTLELGGKSPQIVFADADLDAALPVLVSAIVQNGGQTCSAGSRVLIERAVYE 304 Query: 318 EFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGN 377 V R +G P + GP I+ +Q ++ D + + +G + G + Sbjct: 305 PLVERLATAFNGLRVG-PSRADLDCGPLINAKQQQRVWDFLSDAQHDGIPMAAHGQVVAD 363 Query: 378 ---KGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFT 434 G++ P + +V R+A+EE+FGPV M+F D+ + AN T YGL AG++T Sbjct: 364 APESGFYQAPALLRDVPPSHRLAQEEVFGPVLAAMRFVDEDEAVALANGTPYGLVAGIWT 423 Query: 435 KDIDKAITISSALQAGTVWVNCYGVVSA-QCPFGGFKMSGNGRELGEYGFHEYTEVKTVT 493 +D + + ++ L+AG V++N YG + PFGG SG+GRE G + +T +KT+ Sbjct: 424 RDGARQMRLARRLRAGQVFINNYGAGGGVELPFGGVGHSGHGREKGFEALYGFTALKTIA 483 Query: 494 VKIS 497 ++ Sbjct: 484 IRHG 487 >3RJL-A nrPDB Length = 538 Score = 484 bits (1246), Expect = e-137, Method: Composition-based stats. Identities = 162/480 (33%), Positives = 246/480 (51%), Gaps = 17/480 (3%) Query: 23 IFINNEWHDSVSGKKFPVFNPAT-EEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 + I+ E ++ + K NPA EE + V + ++ +KA++AA +AF+ WR D Sbjct: 40 LVIDGERYE--TENKIVSINPANKEEVVGTVSKATQDHAEKAIQAAAKAFET---WRYTD 94 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI- 140 ER +L++ + R + + + GK ++ A D A I + Y A ++ Sbjct: 95 PEERAAVLFRAVAKVRRKKHEFSALLVKEAGKPWNEAD-ADTAEAIDFMEYYARQMIELA 153 Query: 141 QGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200 +G+ + + P GV I PWNF ++ + GNTVV+KPA P+ Sbjct: 154 KGKPVNSREGERNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASAAPV 213 Query: 201 TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGK 260 A +++E+G P GVVN VPG G G + H + FTGS EVG I E A K Sbjct: 214 IAAKFVEVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSIITFTGSREVGTRIFERAAK 273 Query: 261 -----SNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESI 315 ++LK+V E+GGK +V D D++ A + F GQ C A SR V E + Sbjct: 274 VQPGQTHLKQVIAEMGGKDTVVVDEDCDIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKV 333 Query: 316 YDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPW 375 YDE ++R +E + +G P + V GP ID+ ++KI+D IE GK+EG +L GG Sbjct: 334 YDEVLKRVIEITESKKVGEPDSADVYMGPVIDQASFNKIMDYIEIGKEEG-RLVSGGKGD 392 Query: 376 GNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435 +KGYF++PT+F+++ + R+ +EEIFGPV K S D+ ++ ANNT YGL+ V TK Sbjct: 393 DSKGYFIEPTIFADLDPKARLMQEEIFGPVVAFSKVSSFDEALEVANNTEYGLTGAVITK 452 Query: 436 DIDKAITISSALQAGTVWV--NCYGVVSAQCPFGGFKMSGNGRE-LGEYGFHEYTEVKTV 492 + D G ++ NC G + PFGGFKMSG + G + + KT+ Sbjct: 453 NRDHINRAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQAKTI 512 >5VBF-A nrPDB Length = 478 Score = 483 bits (1245), Expect = e-137, Method: Composition-based stats. Identities = 159/473 (33%), Positives = 237/473 (50%), Gaps = 6/473 (1%) Query: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 +++I+ +HD+ + PV +P T L ++ D+D AV+AA +AF WR Sbjct: 8 RLYIDGRFHDADGRRTQPVVDPGTTRVLGELPHATAHDIDAAVQAAHRAFVT---WRHES 64 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 R LL + A L + +M+ GK A + ++ + L + A + Sbjct: 65 PLVRSDLLRRAAALARERAETIGRHITMDQGKPLREA-IAEVVSAAEQLEWHAEEGRRTY 123 Query: 142 GRTIPIDGNFFTYTR-HEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200 GR +P T EPIGVC PWNFP + KI AL+ G T+V+K E++P Sbjct: 124 GRVVPARSPDVMQTVLREPIGVCAAFSPWNFPFSQAMHKIAAALASGCTLVLKGPEESPS 183 Query: 201 TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGK 260 + +A L +AG PPG +NIV G + + K++FTGS VGK + A Sbjct: 184 AIVALAQLFHDAGLPPGCLNIVWGVPGDVSKQLIEAPQVRKISFTGSVPVGKQLAALAA- 242 Query: 261 SNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFV 320 S +KR+T+ELGG +P +V ADAD++ A F + GQ C++ +R FV+ + +D FV Sbjct: 243 SLMKRMTMELGGHAPVLVCADADVERAAAMLAAYKFRNAGQVCVSPTRFFVQRAAFDRFV 302 Query: 321 RRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGY 380 ++ +G L GVT GP + D+I + +GA++ GG G+ Sbjct: 303 CAYLDAVGTIRVGYGLDAGVTMGPLAHARRVDEIDAFVADATAKGAQIATGGMRLPGPGH 362 Query: 381 FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKA 440 + PTV T + R+ +E FGP+ I+ F LDD + AN +GL++ FT A Sbjct: 363 YFAPTVVLGPTRDTRLMNDEPFGPIVGIVPFDDLDDALAEANRLPFGLASYAFTTSARNA 422 Query: 441 ITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVT 493 IS AL+AG V +N +G+ A+ PFGG K SG G E G F Y K VT Sbjct: 423 HRISRALEAGMVNINHFGMGPAEIPFGGVKDSGFGSEGGMEAFDGYLVTKFVT 475 >3RH9-A nrPDB Length = 506 Score = 483 bits (1245), Expect = e-137, Method: Composition-based stats. Identities = 165/471 (35%), Positives = 252/471 (53%), Gaps = 7/471 (1%) Query: 24 FINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDAS 83 +I W DS G F V+NPAT + +V +EDV AV+A + A ++ +PW Sbjct: 15 YIGGRWKDSAGGATFDVYNPATGSVIAKVPSMPEEDVVAAVEAGQSALRLTNPW---PIE 71 Query: 84 ERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGR 143 R + L + D ++ +R + + M GK + A ++ YCA + Sbjct: 72 TRRKWLEDIRDGLKENREEIGRILCMEHGKPWKEAQ-GEVDYAAGFFDYCAKHISALDSH 130 Query: 144 TIPIDGNFFTYT-RHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTA 202 TIP T+T + P+GV G I+PWNFP+ M+ K+ AL+ G V+KPA +TPLT Sbjct: 131 TIPEKPKDCTWTVHYRPVGVTGLIVPWNFPIGMIAKKLSAALAAGCPSVIKPASETPLTM 190 Query: 203 LHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSN 262 + S++ + P G+VN+V G G + H D+ ++FTGSTEVG+ + + Sbjct: 191 IAFFSVMDKLDLPDGMVNLVMGKASVIGKVLCEHKDVPMLSFTGSTEVGRKLIVDTAEQ- 249 Query: 263 LKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRR 322 +K++ LELGG +P IV DADL+ A + F GQ C+ A+RIFV E + D F ++ Sbjct: 250 VKKLALELGGNAPFIVFDDADLEAAADNLIANKFRGGGQTCVCANRIFVHEKVADAFGQK 309 Query: 323 SVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG-NKGYF 381 ER K +G+ + G+ GP I+K+ +DK+ ++ +GA L G P G F Sbjct: 310 LAERVNKMTVGDGMNDGIDIGPLINKQGFDKVKRHLQDALDKGASLVAGKQPAELGDGLF 369 Query: 382 VQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAI 441 PTV V EM +EE FGP+ + F++ ++VI N+T +GL++ VFT D ++A Sbjct: 370 FPPTVVQGVDREMCCYQEETFGPLVPMALFRTEEEVIDAGNDTEFGLASYVFTADAERAQ 429 Query: 442 TISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492 +++ L+ G V N + + PFGG K SG GRE G G E+ E +TV Sbjct: 430 RVAAGLRFGHVGWNTGTGPTPEAPFGGMKASGIGREGGLEGLFEFVEAQTV 480 >2W8P-A nrPDB Length = 487 Score = 482 bits (1242), Expect = e-136, Method: Composition-based stats. Identities = 167/481 (34%), Positives = 251/481 (52%), Gaps = 12/481 (2%) Query: 18 IQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPW 77 + T F+ W + FPV +PA+ L V + + AV+AA +AF W Sbjct: 10 LLRTDSFVGGRWLPAA--ATFPVQDPASGAALGMVADCGVREARAAVRAAYEAF---CRW 64 Query: 78 RTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWA 137 R + A ER LL K +L+ +++ LA + + GK A+ ++ L + + A Sbjct: 65 REVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILYSAFFLEWFSEEA 123 Query: 138 DKIQGRTIPID-GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAE 196 ++ G I + +PIGV I PWNFP M+ K+G AL+ G TVVVKPAE Sbjct: 124 RRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAE 183 Query: 197 QTPLTALHVASLIKEAGFPPGVVNIVPGYGP---TAGAAISSHMDIDKVAFTGSTEVGKL 253 TP +AL +A L +AG P GV N++P G AI + + K++FTGST GK+ Sbjct: 184 DTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKI 243 Query: 254 IKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEE 313 + A S +KRV++ELGG +P IV A++D AV A F + GQ + +++ V+ Sbjct: 244 LLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTAVCSNQFLVQR 302 Query: 314 SIYDEFVRRSVERAKK-YILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGG 372 I+D FV+ E KK +GN G TQGP I+++ +K+ + +GA + GG Sbjct: 303 GIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG 362 Query: 373 GPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGV 432 F +PT+ NVT +M EE FGP+ ++KF + ++ I AN GL+ Sbjct: 363 KRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYF 422 Query: 433 FTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492 +++D + ++ L+ G V VN + S +CPFGG K SG GRE +YG EY E+K V Sbjct: 423 YSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 482 Query: 493 T 493 Sbjct: 483 C 483 >2JG7-A nrPDB Length = 510 Score = 479 bits (1234), Expect = e-135, Method: Composition-based stats. Identities = 137/481 (28%), Positives = 228/481 (47%), Gaps = 16/481 (3%) Query: 26 NNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASER 85 N W SG+ + PA E + +V + + ++ V+ R+A+++ W + A +R Sbjct: 27 NGSW--GGSGEVITSYCPANNEPIARVTQATLAEYEETVQKTREAWKM---WADIPAPKR 81 Query: 86 GRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTI 145 G ++ ++ D + + +L ++ S+ GK+Y + ++ + Y G + I G + Sbjct: 82 GEIVRQIGDALRKKIKVLGSLVSLEMGKIYVEG-VGEVQEYVDVCDYAVGLSRMIGGPVL 140 Query: 146 PIDGNFFTYTRHE-PIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALH 204 P + P+G+ G I +NFP+ + W AL+CGN + K A TPLT++ Sbjct: 141 PSERPGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIALTCGNVCLWKGAPTTPLTSVA 200 Query: 205 V----ASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGK 260 V A ++++ P G + + G G A++ +D ++FTGST VGK++ + Sbjct: 201 VTKIVAEVLEQNNLP-GAICSMTCGGADIGTAMAKDERVDLLSFTGSTHVGKMVAMMV-Q 258 Query: 261 SNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFV 320 R LELGG + IV DADL+ V A GQ C R+ + ES++D V Sbjct: 259 ERFGRKLLELGGNNAIIVFEDADLNLVVPSAVFASVGTAGQRCTTTRRLMLHESVHDAVV 318 Query: 321 RRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGY 380 R + K+ +G+P P GP K+ D+ L IE K++G L CGG G Sbjct: 319 ERIAKAYKQVRIGDPWDPSTLYGPLHTKQAVDQYLAAIEQAKQQGGTLVCGGKVMDRPGN 378 Query: 381 FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKA 440 +V+PT+ + + + I E F P+ ++KFK+ ++ N GLS+ +FTKD+ + Sbjct: 379 YVEPTIITGLAHDAPIVHTETFVPILYVLKFKTEEEAFAWNNEVQQGLSSSIFTKDLGRV 438 Query: 441 ITIS--SALQAGTVWVN-CYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKIS 497 G V VN FGG K +G GRE G + +Y T T+ S Sbjct: 439 FRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDSWKQYMRRSTCTINYS 498 Query: 498 Q 498 + Sbjct: 499 K 499 >5TJR-A nrPDB Length = 531 Score = 476 bits (1226), Expect = e-135, Method: Composition-based stats. Identities = 153/489 (31%), Positives = 250/489 (51%), Gaps = 16/489 (3%) Query: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 K I E + +G+ VFNP+T E + +V D+E + +A+ AA+ AF WR Sbjct: 38 KHLIGGELI-ADTGRTADVFNPSTGEAVRKVPLADRETMQQAIDAAKAAF---PAWRNTP 93 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 ++R ++L++ L+E + + + S GK +A +L I+ + Y + ++ Sbjct: 94 PAKRAQVLFRFKQLLEANEERIVKLISEEHGKTIEDA-AGELKRGIENVEYATAAPEILK 152 Query: 142 GR-TIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200 G + + N ++ +PIGV I P+NFP ++ +W A++CGNT ++KP+E+ P Sbjct: 153 GEYSRNVGPNIDAWSDFQPIGVVAGITPFNFPAMVPLWMYPLAIACGNTFILKPSERDPS 212 Query: 201 TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGK 260 + L +A L EAG P GV+N+V G A+ ++ ++F GST + + I G Sbjct: 213 STLLIAELFHEAGLPKGVLNVVHGDKGAV-DALIEAPEVKALSFVGSTPIAEYIYSE-GT 270 Query: 261 SNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAAS-RIFVEESIYDEF 319 KRV G K+ +++ DADLDNAV + G+ C+A S + V + I D Sbjct: 271 KRGKRVQALGGAKNHAVLMPDADLDNAVSALMGAAYGSCGERCMAISVAVCVGDQIADAL 330 Query: 320 VRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG--- 376 V++ V + K +G + G+ GP + DK+ I++G +GA+L G + Sbjct: 331 VQKLVPQIKGLKIGAGTSCGLDMGPLVTGAARDKVTGYIDTGVAQGAELVVDGRGYKVAG 390 Query: 377 -NKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435 G+F+ T+F VT EM I KEEIFGPV I++ SL++ ++ N+ YG +FT+ Sbjct: 391 HENGFFLGGTLFDRVTPEMTIYKEEIFGPVLCIVRVNSLEEAMQLINDHEYGNGTCIFTR 450 Query: 436 DIDKAITISSALQAGTVWVN-CYGVVSAQCPFGGFKMS--GNGRELGEYGFHEYTEVKTV 492 D + A ++ G V VN V A FGG+K S G+ G G YT+ K + Sbjct: 451 DGEAARLFCDEIEVGMVGVNVPLPVPVAYHSFGGWKRSLFGDLHAYGPDGVRFYTKRKAI 510 Query: 493 TVKISQKNS 501 T + Q+ S Sbjct: 511 TQRWPQRKS 519 >4X0T-A nrPDB Length = 513 Score = 469 bits (1208), Expect = e-132, Method: Composition-based stats. Identities = 140/480 (29%), Positives = 221/480 (46%), Gaps = 14/480 (2%) Query: 26 NNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASER 85 N W G+ + PA E + +V + D ++ VK AR+A++I W + A +R Sbjct: 30 NGSW--GGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKI---WADIPAPKR 84 Query: 86 GRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTI 145 G ++ ++ D + +L ++ S+ GK+ + ++ + Y G + I G + Sbjct: 85 GEIVRQIGDALREKIQVLGSLVSLEMGKILVEG-VGEVQEYVDICDYAVGLSRMIGGPIL 143 Query: 146 PIDGNFFTYTRHE-PIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALH 204 P + + P+G+ G I +NFP+ + W A+ CGN + K A T L ++ Sbjct: 144 PSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVA 203 Query: 205 VASLIK---EAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKS 261 V +I E PG + + G G A++ ++ ++FTGST+VGK + + Sbjct: 204 VTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMV-QE 262 Query: 262 NLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVR 321 R LELGG + I DADL V A GQ C A R+F+ ESI+DE V Sbjct: 263 RFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVN 322 Query: 322 RSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYF 381 R + + +GNP P V GP K+ L +E KKEG + GG G + Sbjct: 323 RLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNY 382 Query: 382 VQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAI 441 V+PT+ + + + IA E F P+ + KFK+ ++V N GLS+ +FTKD+ + Sbjct: 383 VEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIF 442 Query: 442 TIS--SALQAGTVWVN-CYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQ 498 G V VN FGG K +G GRE G + +Y T T+ S+ Sbjct: 443 RWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSK 502 >2QE0-A nrPDB Length = 475 Score = 466 bits (1199), Expect = e-131, Method: Composition-based stats. Identities = 155/483 (32%), Positives = 237/483 (49%), Gaps = 20/483 (4%) Query: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 K ++N EW +S + ++ PA+ EL V E+VD +A++A WR + Sbjct: 6 KNYVNGEWK--LSENEIKIYEPASGAELGSVPAMSTEEVDYVYASAKKAQ---PAWRALS 60 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 ER L+K+AD++ RD+ + + S K Y +A ++++ + + Y A +++ Sbjct: 61 YIERAAYLHKVADILMRDKEKIGAILSKEVAKGYKSA-VSEVVRTAEIINYAAEEGLRME 119 Query: 142 GRTI------PIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPA 195 G + R EP+G+ I P+N+P+ + KI PAL GN + KP Sbjct: 120 GEVLEGGSFEAASKKKIAVVRREPVGLVLAISPFNYPVNLAGSKIAPALIAGNVIAFKPP 179 Query: 196 EQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIK 255 Q ++ L +A EAG P GV N + G G G I H ++ + FTGST +G+ I Sbjct: 180 TQGSISGLLLAEAFAEAGLPAGVFNTITGRGSEIGDYIVEHQAVNFINFTGSTGIGERIG 239 Query: 256 EAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESI 315 + AG ++ + L LGGK IVL DADL+ + G F + GQ C A R+ V ES+ Sbjct: 240 KMAG---MRPIMLALGGKDSAIVLEDADLELTAKNIIAGAFGYSGQRCTAVKRVLVMESV 296 Query: 316 YDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPW 375 DE V + E+ +GNP P ID + D + LI +GA Sbjct: 297 ADELVEKIREKVLALTIGNP-EDDADITPLIDTKSADYVEGLINDANDKGATALT---EI 352 Query: 376 GNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435 +G + P +F VT +MR+A EE FGPV I++ S+++ I+ +N + YGL A +FT Sbjct: 353 KREGNLICPILFDKVTTDMRLAWEEPFGPVLPIIRVTSVEEAIEISNKSEYGLQASIFTN 412 Query: 436 DIDKAITISSALQAGTVWVNCYGVVS-AQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTV 494 D +A I+ L+ GTV +N PF G K SG G + +Y T VK+V Sbjct: 413 DFPRAFGIAEQLEVGTVHINNKTQRGTDNFPFLGAKKSGAGIQGVKYSIEAMTTVKSVVF 472 Query: 495 KIS 497 I Sbjct: 473 DIK 475 >4DNG-A nrPDB Length = 485 Score = 465 bits (1198), Expect = e-131, Method: Composition-based stats. Identities = 152/479 (31%), Positives = 240/479 (50%), Gaps = 12/479 (2%) Query: 21 TKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80 K FIN +W SG+ + NP + + + ++ A A++A + W Sbjct: 7 NKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGKQLEDAFDIAQKAQK---EWAKS 63 Query: 81 DASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI 140 +R +L K + +R + M + G + + +L I L + ++ Sbjct: 64 TTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKSTI-ELEQTIAILDEAMTYTGEL 122 Query: 141 QG-RTIPIDGNFFTY-TRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQT 198 G + +P D T P+GV I P+NFP+ + + I PA++ GN+VV KP QT Sbjct: 123 GGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLSMRSIAPAIALGNSVVHKPDIQT 182 Query: 199 PLTA-LHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEA 257 ++ +A + AG P GV+N++ G + ++ ++FTGST VG+ I E Sbjct: 183 AISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGMLTNPIPRLISFTGSTAVGRHIGEI 242 Query: 258 AGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYD 317 AG++ KR+ LELGG +P VL+DAD+D AV+ A G F HQGQ C+ +RI V + +YD Sbjct: 243 AGRA-FKRMALELGGNNPFAVLSDADVDRAVDAAIFGKFIHQGQICMIINRIIVHQDVYD 301 Query: 318 EFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGN 377 EFV + R K+ G+ P GP I++ Q +K L++IE K +G +L G Sbjct: 302 EFVEKFTARVKQLPYGDQTDPKTVVGPLINERQIEKALEIIEQAKTDGIELAVEGKRV-- 359 Query: 378 KGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDI 437 G + P VF + +IA+ E+F P+ I+K S + I AN+T YGLS+ VFT D+ Sbjct: 360 -GNVLTPYVFVGADNNSKIAQTELFAPIATIIKAGSDQEAIDMANDTEYGLSSAVFTSDL 418 Query: 438 DKAITISSALQAGTVWVNCYGVVS-AQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495 +K + + +G VN V FGG K SG GR + E+T K ++++ Sbjct: 419 EKGEKFALQIDSGMTHVNDQSVNDSPNIAFGGNKASGVGRFGNPWVVEEFTVTKWISIQ 477 >5UR2-A nrPDB Length = 984 Score = 463 bits (1192), Expect = e-131, Method: Composition-based stats. Identities = 174/487 (35%), Positives = 263/487 (54%), Gaps = 18/487 (3%) Query: 23 IFINNEWHDSVSGKKFPVFNPA-TEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 I INN+ + SGK F NP+ +++ + +++ E ++A++AA+ A++ W+ + Sbjct: 499 IVINNK--ELQSGKIFDRVNPSQSDQIVGKIQMATTEQAEQAMQAAQTAYKT---WKNVP 553 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 +R L+ KLAD++ RDR L + + GK ++ A D+ I RY A ++Q Sbjct: 554 CEQRAALVDKLADIMTRDRFKLIATQVLEVGKPWAEAD-GDIGEAIDFCRYYARHMRELQ 612 Query: 142 GR-TIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200 + ++ ++ GV I PWNFPL +L + A GNTVV+KPAEQ+ + Sbjct: 613 KPLRVGGLPGELSHYIYKSRGVTAVIAPWNFPLAILAGMVTAAAVAGNTVVMKPAEQSTV 672 Query: 201 TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAG- 259 A + +I+EAGFP GV+N +PGYG G I +H +AFTGS VG I A Sbjct: 673 VAWGLMKMIQEAGFPQGVINFLPGYGEEVGEYIVNHKYTTTIAFTGSKAVGLHIMNRAAV 732 Query: 260 ----KSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESI 315 + ++KR +E+GGK+ I+ DADLD AV+ + F GQ C AASR+ V + + Sbjct: 733 VQPGQQHVKRCIIEMGGKNAVIIDNDADLDEAVDGVIYSAFGFSGQKCSAASRVIVLDEV 792 Query: 316 YDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPW 375 YD FV R VE AK + P GP +DKE YD+IL I +K KL G Sbjct: 793 YDRFVDRLVETAKSIEIHPAENPKAYMGPVVDKEAYDRILGTIAEAEKNH-KLLFKGSVP 851 Query: 376 GNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435 G G+F PT+F +V + ++A+ EIFGPV +++ K+LD + AN+T Y L+ GVF++ Sbjct: 852 GG-GFFAPPTIFGDVPGDAKLAQAEIFGPVVAVIRAKNLDQALDIANSTEYALTGGVFSR 910 Query: 436 DIDKAITISSALQAGTVWVN--CYGVVSAQCPFGGFKMSGNGRE-LGEYGFHEYTEVKTV 492 + L+ G ++VN G + + PFGGFKMSG G + G +Y E V Sbjct: 911 SPANINRVKEELEVGNLYVNRGITGAMVDRHPFGGFKMSGIGSKTGGPDYLKQYMEPACV 970 Query: 493 TVKISQK 499 T ++ Sbjct: 971 TENTLRR 977 >3R64-A nrPDB Length = 508 Score = 462 bits (1190), Expect = e-130, Method: Composition-based stats. Identities = 172/487 (35%), Positives = 258/487 (52%), Gaps = 11/487 (2%) Query: 18 IQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPW 77 I TK I +W + S + NP + + + ++ DVD A +AA++A + W Sbjct: 10 IDATKHLIGGQWVEGNSDRISTNINPYDDSVIAESKQASIADVDAAYEAAKKAQ---AEW 66 Query: 78 RTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWA 137 A+ER ++Y+ A+L+E R + G S A L ++ + A + Sbjct: 67 AATPAAERSAIIYRAAELLEEHREEIVEWLIKESGSTRSKANL-EITLAGNITKESASFP 125 Query: 138 DKIQGRTIPIDGNF-FTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAE 196 ++ GR P + GV G I PWNFPL + I + PAL+ GN VV+KPA Sbjct: 126 GRVHGRISPSNTPGKENRVYRVAKGVVGVISPWNFPLNLSIRSVAPALAVGNAVVIKPAS 185 Query: 197 QTPLTALHV-ASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIK 255 TP+T + A + +EAG P GV++ V G G G +H ++FTGST VG+ + Sbjct: 186 DTPVTGGVIPARIFEEAGVPAGVISTVAGAGSEIGDHFVTHAVPKLISFTGSTPVGRRVG 245 Query: 256 EAA-GKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEES 314 E A +K V LELGG +P +VLADAD+D A + A G F HQGQ C++ +R+ V+ + Sbjct: 246 ELAINGGPMKTVALELGGNAPFVVLADADIDAAAQAAAVGAFLHQGQICMSINRVIVDAA 305 Query: 315 IYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGP 374 ++DEF+ + VE K G+P G GP I+ Q + + IE KKEGA ++ G Sbjct: 306 VHDEFLEKFVEAVKNIPTGDPSAEGTLVGPVINDSQLSGLKEKIELAKKEGATVQVEGPI 365 Query: 375 WGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFT 434 +G V P VFS+VT +M IA+EEIFGP+ ++K + AN + +GLSA V++ Sbjct: 366 ---EGRLVHPHVFSDVTSDMEIAREEIFGPLISVLKADDEAHAAELANASDFGLSAAVWS 422 Query: 435 KDIDKAITISSALQAGTVWVNCYGVVS-AQCPFGGFKMSGNGRELGEYGFHEYTEVKTVT 493 KDID+A + + +G V +N V FGG K SG GR G++ E+T + + Sbjct: 423 KDIDRAAQFALQIDSGMVHINDLTVNDEPHVMFGGSKNSGLGRFNGDWAIEEFTTDRWIG 482 Query: 494 VKISQKN 500 +K S +N Sbjct: 483 IKRSAEN 489 >4ZZ7-A nrPDB Length = 501 Score = 462 bits (1189), Expect = e-130, Method: Composition-based stats. Identities = 145/484 (29%), Positives = 244/484 (50%), Gaps = 16/484 (3%) Query: 23 IFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDA 82 IN + + + VFNPAT E Q++ + V++A+ AA+ AF WR Sbjct: 9 HLINGQLVTENT-RSQNVFNPATGEIGKQLDLASTKTVEQAISAAQHAF---PTWRNTPP 64 Query: 83 SERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQG 142 +R R++++ +L+E+ + + GK+ +A + +L I+ + Y G + ++G Sbjct: 65 LKRARVMFRFKELLEQHADEICRLIGEEHGKIAHDA-MGELQRGIENVEYACGAPELLKG 123 Query: 143 R-TIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLT 201 + + +++ +P+GV I P+NFP+++ +W A+ CGN V+KP+E+ P + Sbjct: 124 EHSRNVGPGIDSWSEFQPMGVVAGITPFNFPVMVPLWMFPMAIVCGNCFVLKPSERDPSS 183 Query: 202 ALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKS 261 L++A L++EAG P GV+N+V G A+ + V+F GST + + I A + Sbjct: 184 TLYIAQLLQEAGLPDGVMNVVNGDKEAV-DALLHDDRVKAVSFVGSTPIAEYIYRTAS-A 241 Query: 262 NLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAAS-RIFVEESIYDEFV 320 N KR G K+ IV+ DAD+DNAV F G+ C+A S + V ++ D V Sbjct: 242 NGKRCQALGGAKNHAIVMPDADMDNAVNQLLGAAFGSSGERCMALSVAVAVGDAAGDALV 301 Query: 321 RRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG---- 376 + + +K +G G GP I ++ +K++ I S +++GA + G Sbjct: 302 SKMTQAMQKLKVGPSTDSGNDFGPVITRQHQEKVIGYINSAEQQGATIVVDGRQPKVPNH 361 Query: 377 NKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKD 436 G+FV T+ +VT EM +EEIFGPV Q+++ ++ D + + YG +FT+D Sbjct: 362 ENGFFVGGTLIDHVTPEMTSYQEEIFGPVLQVVRVATMQDAMDLIDAHEYGNGTCIFTRD 421 Query: 437 IDKAITISSALQAGTVWVN-CYGVVSAQCPFGGFKMS--GNGRELGEYGFHEYTEVKTVT 493 + A S +Q G V +N V A FGG+K S G+ G YT+ KTVT Sbjct: 422 GEAARYFSDNIQVGMVGINIPLPVPVAYHSFGGWKRSLFGDLHAYGPDAVRFYTKRKTVT 481 Query: 494 VKIS 497 + Sbjct: 482 QRWP 485 >3PRL-A nrPDB Length = 505 Score = 461 bits (1187), Expect = e-130, Method: Composition-based stats. Identities = 158/484 (32%), Positives = 241/484 (49%), Gaps = 18/484 (3%) Query: 23 IFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDA 82 I N EW +S +G++ + PA+ L + +E+V+ A++ A+ A +I W+ Sbjct: 14 ILRNGEWVESRTGERISISAPASGVALGSIPALSQEEVNDAIQGAKDAQKI---WKIRPI 70 Query: 83 SERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQG 142 ER LLY ADL+E + ++ + K +A + +++ +R+ A A ++ G Sbjct: 71 HERVDLLYAWADLLEERKEIIGELIMHEVAKPKKSA-IGEVSRTADIIRHTADEALRLNG 129 Query: 143 RTIPIDG------NFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAE 196 T+ D EP+GV I P+N+P+ + KI PAL GNTVV KPA Sbjct: 130 ETLKGDQFKGGSSKKIALVEREPLGVVLAISPFNYPVNLAAAKIAPALVTGNTVVFKPAT 189 Query: 197 QTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKE 256 Q L+ + + + +AG P G++ +V G G G + H ID + FTG T G+ I E Sbjct: 190 QGSLSGIKMVEALADAGAPEGIIQVVTGRGSVIGDHLVEHPGIDMITFTGGTTTGERISE 249 Query: 257 AAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY 316 A + V LELGGK P IVL DADL G F + GQ C A R+FV++S+ Sbjct: 250 KA---KMIPVVLELGGKDPAIVLDDADLKLTASQIVSGAFSYSGQRCTAIKRVFVQDSVA 306 Query: 317 DEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG 376 D+ V E ++ +G+P P ID++ I LI+ + GA L G Sbjct: 307 DQLVANIKELVEQLTVGSP-EDDADITPVIDEKSAAFIQGLIDDALENGATLLSGNKR-- 363 Query: 377 NKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKD 436 +G + PT+ +VT MR+A EE FGPV I++ K ++ I +N + YGL A +FTKD Sbjct: 364 -QGNLLSPTLLDDVTPAMRVAWEEPFGPVLPIIRVKDANEAISLSNQSDYGLQASIFTKD 422 Query: 437 IDKAITISSALQAGTVWVNCYGVVSA-QCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495 D+AI I L+ GTV +N PF G K SG G + + T + + Sbjct: 423 TDRAINIGKHLEVGTVHINAKTERGPDHFPFLGVKKSGLGVQGIKPSLLSMTRERVTVLN 482 Query: 496 ISQK 499 +++ Sbjct: 483 LAEN 486 >6FK3-A nrPDB Length = 536 Score = 460 bits (1184), Expect = e-130, Method: Composition-based stats. Identities = 182/498 (36%), Positives = 261/498 (52%), Gaps = 29/498 (5%) Query: 23 IFINNEWHDSVSGKKFPVFNPATEE-ELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 + E + + G NP+ E + + E DK+ V KA AR+AF + W Sbjct: 22 HLVGGE--EVLEGPLLERRNPSDREDVVARFPEADKDLVRKAALKAREAF---AEWSRTP 76 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 A RG++L+ L ++ER++ L + GK A D+ I T + A ++ Sbjct: 77 APIRGQVLFNLVKILEREKPTLTRLMVREVGKTPKEA-AGDVQEAIDTALFFASEGRRLY 135 Query: 142 GRTIPID-GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200 G+T+P + + +T P+GV G I NFP+ + WK+ PA+ GNTVV KP+E P Sbjct: 136 GQTVPSEMRDKELFTFRRPLGVVGIITAGNFPIAVPSWKLIPAVLTGNTVVWKPSEDAPT 195 Query: 201 TALHVASLIKEAGFPPGVVNIVPGYGP-TAGAAISSHMD---IDKVAFTGSTEVGKLIKE 256 + A L +EAG PPGV+N+V G G + G + MD K AFTGST+VG+ I E Sbjct: 196 LSFVFAKLFEEAGLPPGVLNVVFGGGKGSTGQWMVELMDEGLFQKFAFTGSTQVGRWIGE 255 Query: 257 AAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY 316 AG+ NL R TLELGGK+P +V+ DADLD AVE A F GQ C +A I V+ IY Sbjct: 256 VAGR-NLIRPTLELGGKNPLVVMRDADLDLAVEGAWWSAFATGGQRCTSAGNILVDAPIY 314 Query: 317 DEFVRRSVERAKKYILGNPLT-PGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPW 375 +EF RR +ER + ++GNPL P VT GP I++ + + + G+ EGA+L G G Sbjct: 315 EEFKRRFLERVEATLVGNPLLHPEVTYGPFINERFFARWQEHYRVGEAEGARLLFGRGRI 374 Query: 376 GNK------------GYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANN 423 + G + PTV+ V R+ EE+FGP ++K +++ I AN+ Sbjct: 375 TRENPYPRFLGDPEAGLYGWPTVWE-VRPGTRLFTEEVFGPTINLVKVDGIEEAIAVANS 433 Query: 424 TFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVS-AQCPFGGFKMSGN-GRELGEY 481 T YGLS+ ++T A ++AG +N V + A PFGG K SGN GRE G + Sbjct: 434 TPYGLSSAIYTNHRHWAYLFKVGIRAGMTSINNATVGAEAHLPFGGVKASGNGGRESGIW 493 Query: 482 GFHEYTEVKTVTVKISQK 499 EYT V + S + Sbjct: 494 VLEEYTYWHAVNEEYSGR 511 >6MVR-A nrPDB Length = 767 Score = 460 bits (1184), Expect = e-130, Method: Composition-based stats. Identities = 185/471 (39%), Positives = 266/471 (56%), Gaps = 24/471 (5%) Query: 23 IFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDA 82 FI W G F NPAT + L QV + + DVD AVKAAR+A W D Sbjct: 35 HFIGGAWTAP--GDLFATVNPATGQTLAQVSQATQADVDAAVKAARKAQ---PAWAK-DG 88 Query: 83 SERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQG 142 + R R+LY LA L+++ L A +E+++ GK A D+ + + AG+A ++ G Sbjct: 89 AARARVLYALARLLQKHARLFAVLETLDNGKPIREARDIDVPLAQRHFYHHAGYA-QLMG 147 Query: 143 RTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTA 202 +P P+GVCGQ+IPWNFPL+ML WKI PAL+ GNTVV+KPAE TPLTA Sbjct: 148 TEMP---------DRAPLGVCGQVIPWNFPLLMLAWKIAPALAMGNTVVLKPAEWTPLTA 198 Query: 203 LHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSN 262 L A + +AG P GVVNIV G G G I + +DKVAFTGST VG+ I+EA + Sbjct: 199 LLFADICGQAGVPAGVVNIVTGDGA-VGEMIVTAQ-VDKVAFTGSTAVGRRIREATAGT- 255 Query: 263 LKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRR 322 K ++LELGGK P +V DAD+D+AVE ++++QGQ C A SR+ V+E I D F + Sbjct: 256 GKALSLELGGKGPYVVCDDADIDSAVEGLVDAIWFNQGQVCCAGSRLLVQEGIADVFHAK 315 Query: 323 SVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFV 382 R +G+PL + G + +Q ++ D++ + +G + G + Sbjct: 316 LRARMDSLRIGDPLDKCIDIGAMVHPDQLARVRDMV-AANTDGEVYQT----AVPAGCYY 370 Query: 383 QPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAIT 442 PT+ S + + ++EIFGPV F++ + ++ ANNT YGL+A V++++++ A+ Sbjct: 371 PPTLISGLAPASPLMQQEIFGPVLVSTTFRTPAEAVEIANNTAYGLAASVWSENVNLALD 430 Query: 443 ISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVT 493 ++ L AG VW+N ++ A PFGG + SG GRE G G YT T Sbjct: 431 LAPKLVAGIVWINGTNMMDAAAPFGGVRESGFGREGGWEGLAGYTRPAIAT 481 Score = 123 bits (310), Expect = 2e-28, Method: Composition-based stats. Identities = 63/247 (25%), Positives = 101/247 (40%), Gaps = 12/247 (4%) Query: 19 QYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWR 78 + K++I + G V+ P + L +++D+ AV+A A S W Sbjct: 501 RTAKLYIGGKQTRPDGGYSRAVYGP-KGKLLGHASLSNRKDLRNAVEAMNAA----SGWS 555 Query: 79 TMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWAD 138 R ++LY + + + A GK ++A I L A WAD Sbjct: 556 RTTGHLRAQILYFIGENLSARADEFANRIKDMTGKDGK----AEVAASIDRLFSAAAWAD 611 Query: 139 KIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQT 198 K G+ + EP+G G + P PL+ L+ + PA++ GN V + +E Sbjct: 612 KYDGQVKGVPLRGVALAMKEPVGKIGILCPDAAPLLGLVSLMAPAIAMGNRVTLAASEAF 671 Query: 199 PLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAA 258 PL A ++ + P GVVNI+ G ++ H+D+D V + EAA Sbjct: 672 PLAATDFYQVLDTSDVPAGVVNILTGAHADLAEPMARHLDLDAVW---GLSGHAQVIEAA 728 Query: 259 GKSNLKR 265 NLKR Sbjct: 729 SAGNLKR 735 >4PXN-A nrPDB Length = 525 Score = 455 bits (1170), Expect = e-128, Method: Composition-based stats. Identities = 140/481 (29%), Positives = 217/481 (45%), Gaps = 17/481 (3%) Query: 27 NEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERG 86 W SG +P + + +V E D ++ ++A F W + A +RG Sbjct: 44 GAW--GGSGPTVTSTSPTNNQVIAEVVEASVHDYEEGMRAC---FDAAKTWMAIPAPKRG 98 Query: 87 RLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIP 146 ++ ++ D + L + S+ GK+ + ++ I Y G + ++ G IP Sbjct: 99 EIVRQIGDALRAKLHHLGRLVSLEMGKILPEG-IGEVQEIIDMCDYAVGLSRQLNGSIIP 157 Query: 147 IDG-NFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHV 205 + N P+GV G I +NFP +L W AL CGN VV K A TPL + + Sbjct: 158 SERPNHMMMEVWNPLGVVGVITAFNFPCAVLGWNACIALVCGNCVVWKGAPTTPLITIAM 217 Query: 206 ASL----IKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKS 261 + +++ P + G G G AI+ + I V+FTGST G ++++ Sbjct: 218 TKIVASVLEKNNLPGAIFTSFCG-GTEIGQAIALDIRIPLVSFTGSTRAGLMVQQQVSAR 276 Query: 262 NLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVR 321 K LEL G + IV+ DAD+ AV GQ C R+ + E+IY F+ Sbjct: 277 FGK-CLLELSGNNAIIVMDDADIQLAVRSVLFAAVGTAGQRCTTCRRLILHENIYQTFLD 335 Query: 322 RSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYF 381 + VE K+ +G+PL G GP + L I++ K +G K+ GG ++G F Sbjct: 336 QLVEVYKQVRIGDPLEKGTLLGPLHTPASKENFLKGIQTIKSQGGKILFGGSAIESEGNF 395 Query: 382 VQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAI 441 VQPT+ +T + KEE+FGPV +MKF++L + I+ N+ GLS+ +FTK D Sbjct: 396 VQPTIVE-ITPSAPVVKEELFGPVLYVMKFQTLKEAIEINNSVPQGLSSSIFTKRPDIIF 454 Query: 442 TIS--SALQAGTVWVN-CYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQ 498 G V VN FGG K +G GRE G + +Y T T+ Sbjct: 455 KWLGPHGSDCGIVNVNIPTNGAEIGGAFGGEKATGGGREAGSDSWKQYMRRATCTINYGS 514 Query: 499 K 499 + Sbjct: 515 E 515 >3VZ3-A nrPDB Length = 457 Score = 453 bits (1165), Expect = e-127, Method: Composition-based stats. Identities = 138/458 (30%), Positives = 208/458 (45%), Gaps = 6/458 (1%) Query: 38 FPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIE 97 NP T E + + ++D + A++AFQ +R S+R + L A ++E Sbjct: 6 IATINPTTGEICQRFKALTPAEIDAKLAKAQEAFQA---YRRTSFSQRRQWLENAAAILE 62 Query: 98 RDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRH 157 RD A + + GK + +A + + RY A ++ +Y + Sbjct: 63 RDTSKFAEIMTTEMGKTHQSA-IAEAEKSALVCRYYAEHGEQFLANEYTETQATESYVCY 121 Query: 158 EPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPG 217 +P+G+ ++PWNFP + PAL GN V+K A P AL V ++++ AGFP G Sbjct: 122 QPLGILLAVMPWNFPFWQVFRFAAPALMAGNVAVLKHASNVPQCALAVEAILEAAGFPEG 181 Query: 218 VVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCI 277 V + G + + + TGS G + AG+ +K LELGG P + Sbjct: 182 VFQTLL-IGASQVEQVIKDPRVKAATLTGSEPAGASLASLAGQ-EIKPTLLELGGSDPFV 239 Query: 278 VLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLT 337 V ADLD AVE + GQ IAA R + E+I EF+ + + +G+P+ Sbjct: 240 VFPSADLDEAVEVGTVARTMNNGQSAIAAKRFILHEAIAAEFLEKLHLKFASLKIGDPMA 299 Query: 338 PGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIA 397 P GP + I ++ GAK+ GG P GYF PT+ + + +I Sbjct: 300 PETDIGPLATEGILQDISRQVDQAVAAGAKILLGGRPLDRAGYFYPPTILTEIPPGAKIL 359 Query: 398 KEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCY 457 +EE+F PV + K LD I AN+ +GL A +T D + L AG V++N Sbjct: 360 QEELFAPVAMVFTVKDLDQAIALANDIPFGLGASAWTNDPAEQQRFIQELDAGAVFINGM 419 Query: 458 GVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495 + PFGG K SG GRELG G + KTV +K Sbjct: 420 VKSDPRLPFGGTKRSGYGRELGLAGIRTFVNAKTVWLK 457 >3VZ0-A nrPDB Length = 459 Score = 452 bits (1164), Expect = e-127, Method: Composition-based stats. Identities = 144/458 (31%), Positives = 212/458 (46%), Gaps = 5/458 (1%) Query: 37 KFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLI 96 + NP TE + + A ++ W+ ++R ++ + ADL+ Sbjct: 6 VYQTLNPTTETVERSFDLHTPAQMKDITDRAEHVWKT--DWKLRSIAQRKEIVSRAADLL 63 Query: 97 ERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTR 156 RDR A++ + GK +A L ++ L + A A++ T Sbjct: 64 RRDRQHHASLIATEMGKALPDA-LEEIDVTADILSFYANGAEEFLAPTPLKVKTGQAKII 122 Query: 157 HEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPP 216 ++P+G+ I PWNFP L GP L GN V+ K A P AL L +AG P Sbjct: 123 NQPLGIIYCIEPWNFPYYQLARVAGPNLMAGNVVIAKHAPNVPQCALAFEKLFHDAGAPV 182 Query: 217 GVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPC 276 G + A + I VA TGS A + LK+ T+ELGG Sbjct: 183 GAYANIFLDNDQ-SAELIKDERIRGVALTGSERA-GQAVAAQAGAALKKDTMELGGSDAF 240 Query: 277 IVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPL 336 IVL DADLD AV++A G F + GQ C AA R+ V E +YD F+ ++ +GNPL Sbjct: 241 IVLDDADLDLAVKWAVWGRFANNGQVCTAAKRMIVHEKVYDAFLDGLKTAITRFRIGNPL 300 Query: 337 TPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRI 396 T GP + LD K GA L GG KG+F++PT+ ++V+ + + Sbjct: 301 DRDTTHGPMSSLRAMELALDQTAEAVKGGATLVAGGKRMDRKGFFMEPTILTDVSKDNPV 360 Query: 397 AKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNC 456 +EIFGPV + K S I AN++ YGL VF++DI +A ++ ++ G V++N Sbjct: 361 FYQEIFGPVAVVHKVASEQAAIDLANDSPYGLGGAVFSRDIARAEKVAEQVETGMVFINT 420 Query: 457 YGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTV 494 + + PFGG K SG GREL G E+ K V + Sbjct: 421 ATAAAPELPFGGIKNSGFGRELSFLGIEEFINRKLVRI 458 >3ROS-A nrPDB Length = 484 Score = 451 bits (1161), Expect = e-127, Method: Composition-based stats. Identities = 138/465 (29%), Positives = 222/465 (47%), Gaps = 9/465 (1%) Query: 37 KFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLI 96 K+ NP T E + + +D+A+ A ++ WR + + R +L+ +A+ + Sbjct: 5 KYQSVNPYTNEAFASYDNPTSKQIDEAINLAHALYK---KWRHEEPASRAEILHDIANAL 61 Query: 97 ERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTR 156 + LA M ++ GKL S + ++ C+ Y A ++ T Y Sbjct: 62 KEHEDELAKMMTLEMGKLLSESK-EEVELCVSICNYYADHGPEMLKPTKLNSDLGNAYYL 120 Query: 157 HEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPP 216 + GV PWNFPL +I P GN +++K A P +A A +IK AG P Sbjct: 121 KQSTGVIMACEPWNFPLYQVIRVFAPNFIVGNPILLKHAHNVPGSAALTAKIIKRAGAPE 180 Query: 217 G-VVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSP 275 G ++N+ P Y A I + I VA TGS G + EAAGK NLK+ T+ELGG Sbjct: 181 GSLINLYPSYDQLAD--IIADPRIQGVALTGSERGGSAVAEAAGK-NLKKSTMELGGNDA 237 Query: 276 CIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNP 335 IVL DAD + Y+ GQ C ++ RI VE+S YDE + G+P Sbjct: 238 FIVLDDADPQVLRNVLNDARTYNDGQVCTSSKRIIVEKSRYDEVLHELKNVFSNLKAGDP 297 Query: 336 LTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMR 395 L T P ++ +K+ ++ GAK+ +KG F +PT+ +++ + Sbjct: 298 LEADTTLPPMNSEKAKEKLEAQVKEAIDAGAKVFYQYPEIDSKGAFFRPTILTDIAKDNP 357 Query: 396 IAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVN 455 + +E+FGP+ ++ + + I+ AN++ YGL + V DID+A +S+ ++ G +N Sbjct: 358 VFDKEVFGPIAEVFVVEDDNAAIQLANDSSYGLGSSVIGSDIDRAKKVSAQIETGMTVIN 417 Query: 456 CYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKN 500 + S + PFGG K SG GREL G + V + +++ N Sbjct: 418 GRWITSGELPFGGIKKSGYGRELSGLGLMAFVNEHLV-IDVTKNN 461 >4OGD-A nrPDB Length = 465 Score = 451 bits (1160), Expect = e-127, Method: Composition-based stats. Identities = 139/466 (29%), Positives = 218/466 (46%), Gaps = 9/466 (1%) Query: 38 FPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD-ASERGRLLYKLADLI 96 + P T E L + + + ++ A + WR D ER L+++A+++ Sbjct: 3 YQTIYPYTNEVLHTFDNMTDQGLADVLERAH---LLYKKWRKEDHLEERKAQLHQVANIL 59 Query: 97 ERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTR 156 RDR A + + + GKL++ A ++ C Y A AD+ T + Y Sbjct: 60 RRDRDKYAEIMTKDMGKLFTEAQ-GEVDLCADIADYYADKADEFLMSTPLETDSGQAYYL 118 Query: 157 HEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPP 216 + GV + PWNFP ++ P GN +V+K A P +A L+ EAG Sbjct: 119 KQSTGVILAVEPWNFPYYQIMRVFAPNFIVGNPMVLKHASICPRSAQSFEELVLEAGAEA 178 Query: 217 G-VVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSP 275 G + N+ Y + + + + V TGS G I E AGK NLK+ TLELGG Sbjct: 179 GSITNLFISYDQV--SQVIADKRVVGVCLTGSERGGASIAEEAGK-NLKKTTLELGGDDA 235 Query: 276 CIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNP 335 I+L DAD D + + Y+ GQ C ++ R V + YD F + K G+P Sbjct: 236 FIILDDADWDQLEKVLYFSRLYNAGQVCTSSKRFIVLDKDYDRFKELLTKVFKTAKWGDP 295 Query: 336 LTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMR 395 + P T P + +LD I+ GA+L GG + G+FV PT+ + +T + Sbjct: 296 MDPETTLAPLSSAQAKADVLDQIKLALDHGAELVYGGEAIDHPGHFVMPTIIAGLTKDNP 355 Query: 396 IAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVN 455 I +EIFGPV +I K S ++ I+ AN++ YGL +F+ + + A +++ ++ G ++N Sbjct: 356 IYYQEIFGPVGEIYKVSSEEEAIEVANDSNYGLGGTIFSSNQEHAKAVAAKIETGMSFIN 415 Query: 456 CYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKNS 501 + PFGG K SG GREL E GF + + + NS Sbjct: 416 SGWTSLPELPFGGIKHSGYGRELSELGFTSFVNEHLIYIPNKTNNS 461 >3EFV-A nrPDB Length = 462 Score = 445 bits (1146), Expect = e-125, Method: Composition-based stats. Identities = 138/454 (30%), Positives = 211/454 (46%), Gaps = 6/454 (1%) Query: 40 VFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERD 99 NPAT + L + + ++++ A+ A F+ W+ ++R + L + + Sbjct: 11 SVNPATGQTLAAMPWANAQEIEHALSLAASGFK---KWKMTSVAQRAQTLRDIGQALRAH 67 Query: 100 RLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEP 159 +A + GK A ++ + A + + N + P Sbjct: 68 AEEMAQCITREMGKPIKQAR-AEVTKSAALCDWYAEHGPAMLNPEPTLVENQQAVIEYRP 126 Query: 160 IGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVV 219 +GV I+PWNFPL ++ P L GN+ ++K A A +A ++ EAG P GV Sbjct: 127 LGVILAIMPWNFPLWQVLRGAVPILLAGNSYLLKHAPNVTGCAQMIARILAEAGTPAGVY 186 Query: 220 NIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVL 279 V + + I V TGS A + LK+ LELGG P IVL Sbjct: 187 GWVNANNEGVSQ-MINDPRIAAVTVTGSVRA-GAAIGAQAGAALKKCVLELGGSDPFIVL 244 Query: 280 ADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPG 339 DADL+ AV+ A G + + GQ C AA R VEE I F R V A +G+PL Sbjct: 245 NDADLELAVKAAVAGRYQNTGQVCAAAKRFIVEEGIAQAFTDRFVAAAAALKMGDPLVEE 304 Query: 340 VTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKE 399 GP + D++ +++ EGA+L GG +G + TV ++VT +M ++ Sbjct: 305 NDLGPMARFDLRDELHQQVQASVAEGARLLLGGEKIAGEGNYYAATVLADVTPDMTAFRQ 364 Query: 400 EIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGV 459 E+FGPV I K + AN++ +GLSA +FT D A +++ L+ G V++N Y Sbjct: 365 ELFGPVAAITVAKDAAHALALANDSEFGLSATIFTADDTLAAEMAARLECGGVFINGYSA 424 Query: 460 VSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVT 493 A+ FGG K SG GREL +G HE+ V+TV Sbjct: 425 SDARVAFGGVKKSGFGRELSHFGLHEFCNVQTVW 458 >2J5N-A nrPDB Length = 516 Score = 440 bits (1131), Expect = e-124, Method: Composition-based stats. Identities = 167/487 (34%), Positives = 243/487 (49%), Gaps = 25/487 (5%) Query: 23 IFINNEWHDSVSGKKFPVFNP-ATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 ++I EW D + ++ NP A E + + K + + A++AA +AF+ W Sbjct: 40 LYIGGEWVD--TKERMVSLNPSAPSEVVGTTAKAGKAEAEAALEAAWKAFKTWKDW---P 94 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 +R RLL K A L+ R + L GK + A D+A I + Y A A + + Sbjct: 95 QEDRSRLLLKAAALMRRRKRELEATLVYEVGKNWVEAS-ADVAEAIDFIEYYARAALRYR 153 Query: 142 GRTI-----PIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAE 196 + P + N Y P+G I PWNFP+ + I ++ GNTV+ KPAE Sbjct: 154 YPAVEVVPYPGEDNESFYV---PLGAGVVIAPWNFPVAIFTGMIVGPVAVGNTVIAKPAE 210 Query: 197 QTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKE 256 + V + EAGFPPGVVN +PG G GA + H I + FTGS EVG I E Sbjct: 211 DAVVVGAKVFEIFHEAGFPPGVVNFLPGVGEEVGAYLVEHPRIRFINFTGSLEVGLKIYE 270 Query: 257 AA-----GKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFV 311 AA G++ KR +E GGK IV AD D A E + QGQ C AASR+ + Sbjct: 271 AAGRLAPGQTWFKRAYVETGGKDAIIVDETADFDLAAEGVVVSAYGFQGQKCSAASRLIL 330 Query: 312 EESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECG 371 + Y+ + R ++RA++ +G P GP + EQ K+L IE GK EG +L G Sbjct: 331 TQGAYEPVLERVLKRAERLSVG-PAEENPDLGPVVSAEQERKVLSYIEIGKNEG-QLVLG 388 Query: 372 GGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAG 431 G +GYF+ PTVF+ V + RIA+EEIFGPV +++ K + ++ AN+T YGL+ G Sbjct: 389 GKRLEGEGYFIAPTVFTEVPPKARIAQEEIFGPVLSVIRVKDFAEALEVANDTPYGLTGG 448 Query: 432 VFTKDIDKAITISSALQAGTVWVN--CYGVVSAQCPFGGFKMSGNGRELGE-YGFHEYTE 488 V+++ + G ++ N G + PFGGFK+SG + G + E Sbjct: 449 VYSRKREHLEWARREFHVGNLYFNRKITGALVGVQPFGGFKLSGTNAKTGALDYLRLFLE 508 Query: 489 VKTVTVK 495 +K V + Sbjct: 509 MKAVAER 515 >5KF0-A nrPDB Length = 485 Score = 439 bits (1129), Expect = e-123, Method: Composition-based stats. Identities = 137/435 (31%), Positives = 207/435 (47%), Gaps = 16/435 (3%) Query: 69 QAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIK 128 A P R + A R +L LA + GK +++ ++ I Sbjct: 57 AAVDAVKPMRELPAYRRQAVLDHCVARFRERFDELAEALCIEAGKPINDSR-GEVTRLID 115 Query: 129 TLRYCAGWADKIQGRTIPID-----GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPA 183 T R + A +I G + ++ + YTR PIG C I P+NFPL + K+ PA Sbjct: 116 TFRVASEEAVRIDGEVLNLEISARAQGYTGYTRRVPIGPCSFISPFNFPLNLAAHKVAPA 175 Query: 184 LSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVA 243 L+ G V+KPA +TP+ AL +A ++ E P G +++P + A ++ ++ Sbjct: 176 LAAGCPFVLKPASRTPVGALIIAEVLAETNLPKGAFSVLPAHRDGA-DLFTTDERFRLLS 234 Query: 244 FTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADA--DLDNAVEFAHHGVFYHQGQ 301 FTGS VG +KE AGK K+V LELGG + IV AD LD V+ G +Y GQ Sbjct: 235 FTGSPAVGWALKEKAGK---KKVVLELGGNAAAIVDADQFEQLDYVVDRLAFGAYYQSGQ 291 Query: 302 CCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESG 361 CI RI V S+YD + V + + +G+P P GP I + + ++ +++ Sbjct: 292 SCIGVQRILVHASLYDTLRDKLVAKTRSLKMGDPKDPSTFVGPMISESESRRLSGWMDAA 351 Query: 362 KKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRA 421 GAK+ GG G + T+ +V E + ++E FGPV + KF DD + R Sbjct: 352 VAAGAKIIAGGKV---DGAMFEATLLEDVGREQDLYRKEAFGPVAILEKFDRFDDALARV 408 Query: 422 NNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSA-QCPFGGFKMSGNGRELGE 480 N++ +GL AGVFT + A L+ G V +N P+GG K SG GRE Sbjct: 409 NDSDFGLQAGVFTDSLTHAQRAWDELEVGGVVINDVPSFRVDNMPYGGVKDSGLGREGIR 468 Query: 481 YGFHEYTEVKTVTVK 495 Y + TE + + V+ Sbjct: 469 YAIEDMTEPRLMVVR 483 >5N5S-A nrPDB Length = 515 Score = 438 bits (1126), Expect = e-123, Method: Composition-based stats. Identities = 157/489 (32%), Positives = 237/489 (48%), Gaps = 20/489 (4%) Query: 15 DLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIG 74 D+ + IF+ ++ D K V N T + +V + +D+D A+ AA A Sbjct: 34 DVTPKKYNIFLASKPVDG-DRKWLDVTNKYTNDVAAKVPQATHKDIDDAIDAAVAAAPAM 92 Query: 75 SPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCA 134 + M A ER +L K+ ++ +A +M GK +A ++ I T + A Sbjct: 93 AA---MGAYERKAVLEKVVAELKNRFEEIAQTLTMESGKPIKDAR-GEVTRTIDTFQVAA 148 Query: 135 GWADKIQGRTIPID-----GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNT 189 + +I G IP+D + PIG + PWNFPL ++ K+ PA++ G Sbjct: 149 EESVRIYGEHIPLDISARNKGLQGIVKKFPIGPVSMVSPWNFPLNLVAHKVAPAIAVGCP 208 Query: 190 VVVKPAEQTPLTALHVASLIKEAG-FPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGST 248 V+KPA +TPL+AL + ++ + P G +I+P A + + FTGS Sbjct: 209 FVLKPASRTPLSALILGEILHKIEELPLGAFSILPVSREDA-DMFTVDERFKLLTFTGSG 267 Query: 249 EVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADA-DLDNAVEFAHHGVFYHQGQCCIAAS 307 +G +K AGK K+V +ELGG +PCIV DLD ++ +G FY GQ CI Sbjct: 268 PIGWDMKARAGK---KKVVMELGGNAPCIVDDYVPDLDYTIQRLINGGFYQGGQSCIHMQ 324 Query: 308 RIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAK 367 R++V E +YDE V KK +GNP GP I + I D ++ +G K Sbjct: 325 RLYVHERLYDEVKEGFVAAVKKLKMGNPFEEDTYLGPMISESAAKGIEDWVKEAVAKGGK 384 Query: 368 LECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYG 427 L GG KG F++PTV +V E KEEIFGPV + K+ + +K NNT YG Sbjct: 385 LLTGG---NRKGAFIEPTVIEDVPIEANARKEEIFGPVVLLYKYSDFKEAVKECNNTHYG 441 Query: 428 LSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQ-CPFGGFKMSGNGRELGEYGFHEY 486 L +G+FTKD++KA ++ G V +N + P+GG K SG RE +Y + Sbjct: 442 LQSGIFTKDLNKAFYAFEHMEVGGVILNDSPALRVDSQPYGGLKDSGIQREGVKYAMDDM 501 Query: 487 TEVKTVTVK 495 E K + ++ Sbjct: 502 LETKVLVMR 510 >5JRY-A nrPDB Length = 485 Score = 434 bits (1116), Expect = e-122, Method: Composition-based stats. Identities = 141/466 (30%), Positives = 218/466 (46%), Gaps = 19/466 (4%) Query: 38 FPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIE 97 V + + + +V D + +D A+ AA A P R + A +R +L Sbjct: 29 LEVTDKYSGKVATRVALADAKAIDAAIGAAVDA---TKPMRELPAYKRQAVLDHCVARFR 85 Query: 98 RDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPID-----GNFF 152 LA + GK ++A ++ I T R + A +I G + ++ + Sbjct: 86 ERFDELAEALCIEAGKPINDAK-GEVTRLIDTFRVASEEAVRIDGEVLNLEISARAQGYT 144 Query: 153 TYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEA 212 YTR PIG C I P+NFPL + K+ PAL+ G V+KPA +TP+ AL + ++ E Sbjct: 145 GYTRRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLKPASRTPVGALIIGEVLAET 204 Query: 213 GFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGG 272 P G +++P + A ++ ++FTGS VG +KE AGK K+V LELGG Sbjct: 205 DLPKGAFSVLPAHRDGA-DLFTTDDRFRLLSFTGSPAVGWALKEKAGK---KKVVLELGG 260 Query: 273 KSPCIVLADA--DLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKY 330 + IV AD LD V+ G FY GQ CI RI IYD + + + + Sbjct: 261 NAAAIVDADQLDRLDYVVDRLAFGAFYQSGQSCIGVQRILAHADIYDALRDKLIAKTRSL 320 Query: 331 ILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNV 390 +G+P P GP I + + ++ +++ GAK+ GG G + T+ NV Sbjct: 321 KMGDPKDPSTFVGPMISESESRRLSGWMDAAVAAGAKIVAGGKV---DGAMFEATLLENV 377 Query: 391 TDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAG 450 + + ++E FGP+ + KF DD + R N++ +GL AGVFT + L+ G Sbjct: 378 GRDQDLYRKEAFGPIAILEKFDRFDDALARVNDSDFGLQAGVFTDSLAHTQQAWDELEVG 437 Query: 451 TVWVNCYGVVSA-QCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495 V +N P+GG K SG GRE Y + TE + + V+ Sbjct: 438 GVVINDVPSFRVDNMPYGGVKDSGLGREGIRYAIEDMTEPRLLVVR 483 >4E4G-A nrPDB Length = 521 Score = 431 bits (1110), Expect = e-121, Method: Composition-based stats. Identities = 142/484 (29%), Positives = 226/484 (46%), Gaps = 15/484 (3%) Query: 23 IFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDA 82 FI+ + SG+ +FNPAT E V D+ AV++A+ W + Sbjct: 29 HFIDGKRVAGTSGRVSNIFNPATGEVQGTVALASDADLAAAVESAK---AAQPKWAATNP 85 Query: 83 SERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQG 142 R R+ K L+ + LA M S GK +A D+ ++ + G + Sbjct: 86 QRRARVFMKFVQLLNDNMNELAEMLSREHGKTIDDAK-GDIVRGLEVCEFVIGIPHLQKS 144 Query: 143 R-TIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLT 201 T Y+ +P+G+ I P+NFP ++ +W PA++CGN ++KP+E+ P Sbjct: 145 EFTEGAGPGIDMYSIRQPVGIGAGITPFNFPGMIPMWMFAPAIACGNAFILKPSERDPSV 204 Query: 202 ALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKS 261 + +A L+ EAG P G++N+V G AI +H DI V+F GST + + + A Sbjct: 205 PIRLAELMIEAGLPAGILNVVNGDKGAV-DAILTHPDIAAVSFVGSTPIARYVYGTAA-M 262 Query: 262 NLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAAS-RIFVEESIYDEFV 320 N KR G K+ I++ DADLD A + G+ C+A S + V E + + Sbjct: 263 NGKRAQCFGGAKNHMIIMPDADLDQAANALIGAGYGSAGERCMAISVAVPVGEETANRLI 322 Query: 321 RRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGY 380 + V + +G GP + KE +I LI+SG ++GAKL G + +GY Sbjct: 323 DKLVPMVESLRIGPYTDEKADMGPVVTKEAEQRIRSLIDSGIEQGAKLVVDGRDFKLQGY 382 Query: 381 ----FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKD 436 F+ +F +VT +M I K EIFGPV +++ ++ ++ + YG ++T+D Sbjct: 383 ENGHFIGGCLFDDVTPDMDIYKTEIFGPVLSVVRARNYEEALSLPMKHEYGNGVAIYTRD 442 Query: 437 IDKAITISSALQAGTVWVN-CYGVVSAQCPFGGFKMSGNGR--ELGEYGFHEYTEVKTVT 493 D A +S + G V VN V A FGG+K S G + G +T KT+T Sbjct: 443 GDAARDFASRINIGMVGVNVPIPVPLAYHSFGGWKSSSFGDLNQHGTDSIKFWTRTKTIT 502 Query: 494 VKIS 497 + Sbjct: 503 SRWP 506 >5U0M-A nrPDB Length = 497 Score = 425 bits (1094), Expect = e-119, Method: Composition-based stats. Identities = 144/465 (30%), Positives = 210/465 (45%), Gaps = 11/465 (2%) Query: 23 IFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDA 82 ++I+ W G F P T E + EDVD AV+ AR+AF WR Sbjct: 14 VYIDGLWLPG-HGAPFESVQPVTGETVWDGNAASLEDVDAAVREARKAFLA---WRRKSL 69 Query: 83 SERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQG 142 +ER ++ +L+E ++ LA + GK + ++A + + ++ G Sbjct: 70 AERQAVIEAFGELLEANKEELAHQIGLETGKPLWESRT-EVAAMMGKIPISVKAYNERTG 128 Query: 143 RTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTA 202 T RH P GV P+NFP + I PAL GNTVV KP+E TP A Sbjct: 129 HTESDVAGGHAVLRHRPHGVVAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSELTPGVA 188 Query: 203 LHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSN 262 L ++AG P GV+N+V G G G ++ H ID + FTGS+ VG L+ E G Sbjct: 189 ELTVRLWEKAGLPDGVINLVQG-GSDTGKCLARHSLIDGLFFTGSSTVGHLLHEQFGGQP 247 Query: 263 LKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY-DEFVR 321 K + LE+GG +P IV +DLD AV A F GQ C A R+ V + DEF+ Sbjct: 248 EKILALEMGGNNPLIVQNVSDLDGAVHHALQSAFLSAGQRCTCARRLLVPKGKKGDEFLA 307 Query: 322 RSVERAKKYILGN-PLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGY 380 R VE A + + P G I E +++L + ++GA Sbjct: 308 RLVEVAARITVAEFDADPQPFMGSVISAEAANQLLKAQAAMLEKGATSLLEMKQLKPDTG 367 Query: 381 FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKA 440 + P + + + +E FGP+ + ++K D+ ++ ANNT YGLSAG+ + D Sbjct: 368 LLSPGIVD--ATGIELEDQEFFGPLLTVYRYKGFDEALELANNTRYGLSAGILSDDRKLY 425 Query: 441 ITISSALQAGTVWVN-CYGVVSAQCPFGGFKMSGNGRELGEYGFH 484 + ++AG V N S+ PFGG SGN R Y Sbjct: 426 NRLVEEVRAGIVNWNRPLTGASSAAPFGGVGASGNHRPSAYYAAD 470 >5J6B-A nrPDB Length = 485 Score = 423 bits (1089), Expect = e-119, Method: Composition-based stats. Identities = 139/468 (29%), Positives = 215/468 (45%), Gaps = 19/468 (4%) Query: 36 KKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADL 95 + V + T + +V D +D A+ AA A + P R + A R +L Sbjct: 27 AELEVTDKYTGKVATRVALADASAIDAAIAAAVGAQK---PLRALPAFRRQAILEHCVAR 83 Query: 96 IERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQG-----RTIPIDGN 150 LA + GK +++ ++ I T R A + +I+G P Sbjct: 84 FRERFDELAQALCIEAGKPINDSK-GEVTRLIDTFRVAAEESVRIEGGLVNLEISPRAQG 142 Query: 151 FFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIK 210 + Y + PIG C I P+NFPL + K+ PAL+ G V+KPA +TP+ AL + ++ Sbjct: 143 YSGYYKRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLKPASRTPIGALIIGEVLA 202 Query: 211 EAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLEL 270 E P G +I+P + A ++ ++FTGS VG +K+ AGK V LEL Sbjct: 203 ETDLPKGAFSILPAHRDGA-DLFTTDERFKLLSFTGSPTVGWELKKKAGKKK---VVLEL 258 Query: 271 GGKSPCIVLADAD--LDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAK 328 GG + IV AD LD VE G +Y GQ CI RI +YD + + + + Sbjct: 259 GGNAAAIVDADQREVLDYVVERLAFGAYYQSGQSCIGVQRIIAHADVYDALREKLIAKTR 318 Query: 329 KYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFS 388 +G+P P GP I + + ++ +E+ GAK+ GG G + T+ Sbjct: 319 SLKMGDPKDPATFVGPMISESEARRLAGWMEAAVAAGAKIVAGGKV---DGAMFEATLLE 375 Query: 389 NVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQ 448 V + + ++E FGPV + +F DD + R N++ +GL AGVFT + A L+ Sbjct: 376 GVGRDQDLYRKEAFGPVALLERFSDFDDALARVNDSDFGLQAGVFTDSLSHAQRAWDELE 435 Query: 449 AGTVWVNCYGVVSA-QCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495 G V +N P+GG K SG GRE Y + TE++ + V+ Sbjct: 436 VGGVVINDVPSFRVDNMPYGGVKDSGLGREGIRYAIEDMTELRLMVVR 483 >1UXV-A nrPDB Length = 501 Score = 416 bits (1070), Expect = e-116, Method: Composition-based stats. Identities = 158/487 (32%), Positives = 235/487 (48%), Gaps = 24/487 (4%) Query: 24 FINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPW--RTMD 81 ++ EW SG++ V +P + +V +E+V++ + F+ G W R M Sbjct: 22 YLAGEW--GGSGQEIEVKSPIDLATIAKVISPSREEVERTLDV---LFKRGR-WSARDMP 75 Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 +ER +L K AD+IER+ + A + MN GK +A + ++ + LR KI Sbjct: 76 GTERLAVLRKAADIIERNLDVFAEVLVMNAGKP-KSAAVGEVKAAVDRLRLAELDLKKIG 134 Query: 142 GRTIPIDGNFFTY-----TRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAE 196 G IP D + T R EP+GV I P+N+PL + KI + GN VVVKP+ Sbjct: 135 GDYIPGDWTYDTLETEGLVRREPLGVVAAITPFNYPLFDAVNKITYSFIYGNAVVVKPSI 194 Query: 197 QTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKE 256 PL A + +AGFPP + ++ G A I + + V+FTGSTEVG+ + + Sbjct: 195 SDPLPAAMAVKALLDAGFPPDAIALLNLPGKEAEK-IVADDRVAAVSFTGSTEVGERVVK 253 Query: 257 AAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY 316 G +K+ +ELGG P IVL DADLD A + G++ + GQ C A + E +Y Sbjct: 254 VGG---VKQYVMELGGGDPAIVLEDADLDLAADKIARGIYSYAGQRCDAIKLVLAERPVY 310 Query: 317 DEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG 376 + V +R +G+P P V GP I D+++ IE ++G ++ GG G Sbjct: 311 GKLVEEVAKRLSSLRVGDPRDPTVDVGPLISPSAVDEMMAAIEDAVEKGGRVLAGGRRLG 370 Query: 377 NKGYFVQPTVFSNVTD---EMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVF 433 +VQPT+ D +M + K E+F PV ++ K LD I+ AN YGL A VF Sbjct: 371 PT--YVQPTLVEAPADRVKDMVLYKREVFAPVALAVEVKDLDQAIELANGRPYGLDAAVF 428 Query: 434 TKDIDKAITISSALQAGTVWVNCYGVVS-AQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492 +D+ K L+ G +++N PFGG K SG RE Y T KT+ Sbjct: 429 GRDVVKIRRAVRLLEVGAIYINDMPRHGIGYYPFGGRKKSGVFREGIGYAVEAVTAYKTI 488 Query: 493 TVKISQK 499 K Sbjct: 489 VFNYKGK 495 >3SZA-A nrPDB Length = 469 Score = 413 bits (1062), Expect = e-115, Method: Composition-based stats. Identities = 127/442 (28%), Positives = 201/442 (45%), Gaps = 20/442 (4%) Query: 60 VDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAY 119 + +AVK AR AF G RT R + L L LI+ L + + K NAY Sbjct: 20 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 76 Query: 120 LNDLAGCIKTLRYC----AGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVM 175 ++ ++ + Y WA P Y EP+GV I WN+P + Sbjct: 77 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 136 Query: 176 LIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISS 235 I + A++ GN VV+KP+E + A +A++I + + ++ G P + Sbjct: 137 TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 195 Query: 236 HMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGV 295 D + +TGST VGK+I AA K +L VTLELGGKSPC V + DLD A G Sbjct: 196 --RFDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 252 Query: 296 FYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKIL 355 F + GQ C+A I + SI ++ V + + K++ G G I + +++ Sbjct: 253 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVM 311 Query: 356 DLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLD 415 LI EG K+ GG ++ PT+ ++V + + +EEIFGPV I+ +SL+ Sbjct: 312 GLI-----EGQKVAYGG-TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 365 Query: 416 DVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNC--YGVVSAQCPFGGFKMSG 473 + I+ N L+ +F+ + + + +G V N + PFGG SG Sbjct: 366 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSG 425 Query: 474 NGRELGEYGFHEYTEVKTVTVK 495 G G+ F ++ ++ V+ Sbjct: 426 MGSYHGKKSFETFSHRRSCLVR 447 >6DBB-A nrPDB Length = 511 Score = 404 bits (1038), Expect = e-113, Method: Composition-based stats. Identities = 127/481 (26%), Positives = 213/481 (44%), Gaps = 23/481 (4%) Query: 35 GKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLAD 94 G +P L + D ++ + AA AF WRT+ A RG L+ + Sbjct: 27 GNALTARSPLDGATLATLAVDTPADAERKIDAAHDAFL---KWRTVPAPVRGELVRVFGN 83 Query: 95 LIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTY 154 ++ + L + ++ GK+ S L ++ I + G + ++ G TI + Sbjct: 84 VLREHKAELGRLVTLEAGKITSEG-LGEVQEMIDICDFAVGLSRQLYGLTIASERPGHRM 142 Query: 155 TRHE-PIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEA- 212 PIGVCG I +NFP+ + W A CG++VV KP+E+TPLTA+ L+++A Sbjct: 143 METWHPIGVCGVISAFNFPVAVWAWNAALAFVCGDSVVWKPSEKTPLTAIACHVLLQKAL 202 Query: 213 --------GFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLK 264 G P + + G +++ + V+ TGS +G+ + + + L Sbjct: 203 REFEKTHPGVAPAELGQLVLGMRDVGEVLTASKKVPVVSATGSVRMGQEVAKVLSQ-RLA 261 Query: 265 RVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSV 324 R LELGG + IV ADLD V GQ C R+ V S+ ++ + R Sbjct: 262 RGILELGGNNGMIVAPSADLDLVVRAVTFAAVGTAGQRCTTLRRLIVHRSLVEQLLPRIE 321 Query: 325 ERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG---NKGYF 381 + +GNPL G GP +D+ +D + + +++G +++ GG Y+ Sbjct: 322 KAYASVKVGNPLEEGTLVGPLVDRASFDAMQKALADAREQGGEVK-GGERVDVGHADAYY 380 Query: 382 VQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAI 441 V+P + + + + + E F P+ +M + + DD I N GLS+ +FT D+ +A Sbjct: 381 VRPAIV-RMPKQSAVVERETFAPILYVMVYDNFDDAIDVHNAVPQGLSSAIFTNDMREAE 439 Query: 442 TI--SSALQAGTVWVN-CYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQ 498 ++ G V VN FGG K +G GRE G + Y T T+ S+ Sbjct: 440 QFMSAAGSDCGIVNVNIGTSGAEIGGAFGGEKETGGGRESGSDAWKAYMRRATNTINYSR 499 Query: 499 K 499 + Sbjct: 500 Q 500 >4KNA-A nrPDB Length = 495 Score = 404 bits (1038), Expect = e-113, Method: Composition-based stats. Identities = 146/460 (31%), Positives = 210/460 (45%), Gaps = 10/460 (2%) Query: 20 YTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRT 79 T++FI+ W D G F NP T E + + +DV++AV +AR+AF + W Sbjct: 9 MTELFIDGAWVDGA-GPVFASRNPGTNERVWEGASASADDVERAVASARRAF---AAWSA 64 Query: 80 MDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADK 139 +D R ++ + A L+ + LATM GK A + K + ++ Sbjct: 65 LDLDARCTIVKRFAALLVERKEALATMIGRETGKPLWEARTEVASMAAKVDISITAYHER 124 Query: 140 IQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP 199 + P+ + RH P GV P+NFP + I PAL GNTVV KP+E P Sbjct: 125 TGEKRAPM-ADGVAVLRHRPHGVVAVFGPYNFPGHLPNGHIVPALIAGNTVVFKPSELAP 183 Query: 200 LTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAG 259 A + ++AG P GV+N+V G G A+++H ID + FTGS++ G L+ + G Sbjct: 184 GVARATVEIWRDAGLPAGVLNLVQGE-KDTGVALANHRQIDGLFFTGSSDTGTLLHKQFG 242 Query: 260 KSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY-DE 318 + LE+GG +P +V D+D AV A F GQ C A RI V + D Sbjct: 243 GRPEIVLALEMGGNNPLVVAEVEDIDAAVHHAIQSAFLSAGQRCTCARRILVPRGAFGDR 302 Query: 319 FVRRSVERAKKYILGN-PLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGN 377 FV R + A K P G I +++ GA Sbjct: 303 FVARLADVASKITASVFDADPQPFMGAVISARAASRLVAAQARLVGLGASPIIEMKQRDP 362 Query: 378 KGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDI 437 FV + +VT+ + EE FGP+ QI+++ LDD I RAN+T +GLSAG+ D Sbjct: 363 ALGFVNAAIL-DVTNVRELPDEEHFGPLAQIVRYTDLDDAIARANDTAFGLSAGLLADDE 421 Query: 438 DKAITISSALQAGTVWVN-CYGVVSAQCPFGGFKMSGNGR 476 T A++AG V N S+ PFGG SGN R Sbjct: 422 QAWHTFRRAIRAGIVNWNRPTNGASSAAPFGGAGRSGNHR 461 >4LGZ-A nrPDB Length = 563 Score = 403 bits (1036), Expect = e-113, Method: Composition-based stats. Identities = 141/517 (27%), Positives = 236/517 (45%), Gaps = 37/517 (7%) Query: 3 SSGTPDLPVL---LTDLKIQYTKI--FINNE--WHDSVSGKKFPVFNPATEEELCQVEEG 55 S G+P+ L L DLK Q I + +E W + + P FN A ++ + Sbjct: 41 SQGSPERDALQKALKDLKGQTEAIPCVVGDEEVWTSDIQYQLSP-FNHAH--KVAKFCYA 97 Query: 56 DKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIE--RDRLLLATMESMNGGK 113 DK +++A+ AA A + W ++R ++ K AD++ R +LA GK Sbjct: 98 DKALLNRAIDAALAARK---EWDLKPMADRAQVFLKAADMLSGPRRAEVLAKTMV-GQGK 153 Query: 114 LYSNAYLNDLAGCIKTLRYCAGWADKIQGR---TIPIDGNFFTYTRHEPIGVCGQIIPWN 170 A ++ A I R+ A +A +++G ++P N Y E G I P+N Sbjct: 154 TVIQAEIDAAAELIDFFRFNAKFAVELEGEQPISVPPSTNHTVYRGLE--GFVAAISPFN 211 Query: 171 FPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAG 230 F + PAL GN V+ KP++ L + V +++EAG PP ++ VP GPT G Sbjct: 212 FTAIGGNLAGAPAL-MGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPTFG 270 Query: 231 AAISSHMDIDKVAFTGSTEVGKLIKEAAGKS-----NLKRVTLELGGKSPCIVLADADLD 285 ++S + + FTGS K + ++ R+ E GGK+ V + AD+D Sbjct: 271 DTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKNFHFVHSSADVD 330 Query: 286 NAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTP-GVTQGP 344 + V F + GQ C A SR++V +S++ + R +E + +G+P G Sbjct: 331 SVVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSA 390 Query: 345 QIDKEQYDKILDLIESGKKEGA-KLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFG 403 ID + + +I +E + + + GG + GY+V+P + + + I KEEIFG Sbjct: 391 VIDAKAFARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIESKDPQEPIMKEEIFG 450 Query: 404 PVQQIMKFKSLD--DVIKRANN-TFYGLSAGVFTKDIDKAITISSALQ--AGTVWVNC-- 456 PV + + + +K ++ T YGL+ VF +D + L+ AG ++N Sbjct: 451 PVLTVYVYPDDKYRETLKLVDSTTSYGLTGAVFAQDKAIVQEATRMLRNAAGNFYINDKS 510 Query: 457 YGVVSAQCPFGGFKMSGNGRE-LGEYGFHEYTEVKTV 492 G V Q PFGG + SG + G + +T + + Sbjct: 511 TGSVVGQQPFGGARASGTNDKPGGPHYILRWTSPQVI 547 >3V9H-A nrPDB Length = 566 Score = 403 bits (1035), Expect = e-112, Method: Composition-based stats. Identities = 137/517 (26%), Positives = 237/517 (45%), Gaps = 37/517 (7%) Query: 3 SSGTPDLPVL---LTDLKIQYTKI--FINNE--WHDSVSGKKFPVFNPATEEELCQVEEG 55 + G+P+ L L DLK + I + +E W V + P FN ++ + Sbjct: 44 TQGSPERDALQKALKDLKGRMEAIPCVVGDEEVWTSDVQYQVSP-FN--HGHKVAKFCYA 100 Query: 56 DKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIE--RDRLLLATMESMNGGK 113 DK ++KA++AA A + W ++R ++ K AD++ R +LA GK Sbjct: 101 DKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMV-GQGK 156 Query: 114 LYSNAYLNDLAGCIKTLRYCAGWADKIQGR---TIPIDGNFFTYTRHEPIGVCGQIIPWN 170 A ++ A I R+ A +A +++G+ ++P N Y E G I P+N Sbjct: 157 TVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--GFVAAISPFN 214 Query: 171 FPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAG 230 F + PAL GN V+ KP++ L + V +++EAG PP ++ VP GP G Sbjct: 215 FTAIGGNLAGAPAL-MGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFG 273 Query: 231 AAISSHMDIDKVAFTGSTEVGKLIKEAAGKS-----NLKRVTLELGGKSPCIVLADADLD 285 ++S + + FTGS K + + ++ R+ E GGK+ V AD++ Sbjct: 274 DTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVE 333 Query: 286 NAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTP-GVTQGP 344 + V F + GQ C A +R++V S++ + R +E + +G+P G Sbjct: 334 SVVSGTLRSAFEYGGQKCSACARLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSA 393 Query: 345 QIDKEQYDKILDLIESGKKEGA-KLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFG 403 ID + + +I +E + + + GG + GYFV+P + + + I KEEIFG Sbjct: 394 VIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFG 453 Query: 404 PVQQIMKFKSL--DDVIKRANN-TFYGLSAGVFTKDIDKAITISSALQ--AGTVWVNC-- 456 PV + + + ++ ++ T YGL+ VF++D D + L+ AG ++N Sbjct: 454 PVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKS 513 Query: 457 YGVVSAQCPFGGFKMSGNGRE-LGEYGFHEYTEVKTV 492 G + Q PFGG + SG + G + +T + + Sbjct: 514 TGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVI 550 >1AD3-A nrPDB Length = 452 Score = 402 bits (1034), Expect = e-112, Method: Composition-based stats. Identities = 126/443 (28%), Positives = 205/443 (46%), Gaps = 22/443 (4%) Query: 60 VDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAY 119 + VK AR+AF G +T R + L L +I + ++ + + GK +Y Sbjct: 3 ISDTVKRAREAFNSG---KTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 59 Query: 120 LNDLAGCIK----TLRYCAGWA-DKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLV 174 ++A ++ T++ WA D+ +T + Y EP+GV I WN+P Sbjct: 60 YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYPFN 118 Query: 175 MLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAIS 234 + I + A++ GN V++KP+E + A +A+LI + + +V G P + Sbjct: 119 LTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLK 177 Query: 235 SHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHG 294 D + +TGST VGK++ AA K +L VTLELGGKSPC V D DLD A G Sbjct: 178 E--RFDHIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVACRRIAWG 234 Query: 295 VFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKI 354 F + GQ C+A I + SI ++ V + + K + G G I+ + ++ Sbjct: 235 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRV 293 Query: 355 LDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSL 414 LI++ K GG W ++ PT+ +V + + +EEIFGPV I+ +SL Sbjct: 294 KGLIDNQK------VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSL 347 Query: 415 DDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNC--YGVVSAQCPFGGFKMS 472 ++ I+ N L+ VF+ + + + +G V N + PFGG S Sbjct: 348 EEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNS 407 Query: 473 GNGRELGEYGFHEYTEVKTVTVK 495 G G G+ F ++ ++ VK Sbjct: 408 GMGAYHGKKSFETFSHRRSCLVK 430 >3JU8-A nrPDB Length = 490 Score = 396 bits (1018), Expect = e-110, Method: Composition-based stats. Identities = 127/457 (27%), Positives = 193/457 (42%), Gaps = 10/457 (2%) Query: 23 IFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDA 82 +I +W G+ +P + + D VD AV AAR+AF W Sbjct: 8 HYIAGQWLAG-QGETLESLDPVGQGVVWSGRGADATQVDAAVCAAREAF---PAWARRPL 63 Query: 83 SERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQG 142 +R LL + A ++ LA + GK + ++ + + + G Sbjct: 64 EQRIELLERFAATLKSRADELARVIGEETGKPLWES-ATEVTSMVNKVAISVQAFRERTG 122 Query: 143 RTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTA 202 + RH+P GV P+NFP + I PAL GN VV KP+E TP A Sbjct: 123 EKSGPLADATAVLRHKPHGVVAVFGPYNFPGHLPNGHIVPALLAGNCVVFKPSELTPKVA 182 Query: 203 LHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSN 262 +AG P GV+N+V G G G A+++H +D + FTGS+ G L+ G Sbjct: 183 ELTLKAWIQAGLPAGVLNLVQG-GRETGVALAAHRGLDGLFFTGSSRTGNLLHSQFGGQP 241 Query: 263 LKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY-DEFVR 321 K + LE+GG +P +V ADLD AV F GQ C A R+ V + + D + Sbjct: 242 QKILALEMGGNNPLVVEEVADLDAAVYTIIQSAFISAGQRCTCARRLLVPQGAWGDALLA 301 Query: 322 RSVERAKKYILGN-PLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGY 380 R V + +G P G I + +L E +GA+ + Sbjct: 302 RLVAVSATLRVGRFDEQPAPFMGAVISLSAAEHLLKAQEHLIGKGAQPLLAMTQPIDGAA 361 Query: 381 FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKA 440 + P + +V+ EE FGP+ Q++++ I+ AN T YGL+AG+ + ++ Sbjct: 362 LLTPGIL-DVSAVAERPDEEFFGPLLQVIRYSDFAAAIREANATQYGLAAGLLSDSRERF 420 Query: 441 ITISSALQAGTVWVN-CYGVVSAQCPFGGFKMSGNGR 476 +AG V N ++ PFGG SGN R Sbjct: 421 EQFLVESRAGIVNWNKQLTGAASSAPFGGIGASGNHR 457 >4I3V-A nrPDB Length = 488 Score = 394 bits (1012), Expect = e-110, Method: Composition-based stats. Identities = 141/493 (28%), Positives = 223/493 (45%), Gaps = 26/493 (5%) Query: 16 LKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGS 75 + +++ + I D + + V P + + V G E +A A Sbjct: 11 IAVRHEPMRIAGRLVD--TDDRVEVRYPWNDTVVGTVPAGRAEHAREAFAIAAAYQ---- 64 Query: 76 PWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAG 135 + ER ++L A+ + + ++ + ++ G +++ ++ Sbjct: 65 --PKLTRYERQKILLATAEALAARKEEISDVITLELGISKADSLY-EVGRAFDVFTLAGQ 121 Query: 136 WADKIQGRTI-----PIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTV 190 + G P +T EP+ I P+N PL M+ K+ PA++ N V Sbjct: 122 MCIRDDGEIFSCDLTPHGKARKIFTMREPLTAISAITPFNHPLNMVAHKVAPAIATNNCV 181 Query: 191 VVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEV 250 VVKP E TP+TAL +A ++ EAG PP ++++V G+ G + ++ +D V FTGS V Sbjct: 182 VVKPTELTPMTALLLADILYEAGLPPEMLSVVTGWPADIGMEMITNPHVDLVTFTGSVPV 241 Query: 251 GKLIKEAAGKSNLKRVTLELGGKSPCIVLA---DADLDNAVEFAHHGVFYHQGQCCIAAS 307 GKLI A ++ KR LELGG P I+L D DL A + A G + GQ C A Sbjct: 242 GKLI---AANAHYKRQVLELGGNDPLIILNDLSDDDLARAADLAVAGATKNSGQRCTAVK 298 Query: 308 RIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAK 367 RI +ES+ D FV +ERAK+ G+P+ G I ++ + + +EGA Sbjct: 299 RILCQESVADRFVPLVLERAKRLRFGDPMDRSTDLGTVIHEKAAALFEERVMRAAEEGAD 358 Query: 368 LECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDV-IKRANNTFY 426 + G G + P V V + + EE FGP+ I++ DD I +N+T + Sbjct: 359 ILYH---PGRSGALLPPIVVDRVPHQSDLVLEETFGPIIPIVRVPDDDDATITLSNSTAF 415 Query: 427 GLSAGVFTKDIDKAITISSALQAGTVWV-NCYGVVSAQCPFGGFKMSGNG-RELGEYGFH 484 GLS+GV T D + + L+ GTV + G PFGG K SGNG +E Sbjct: 416 GLSSGVCTNDYRRMQKYIAGLKVGTVNIWEVPGYRIEMSPFGGIKDSGNGYKEGVIEAMK 475 Query: 485 EYTEVKTVTVKIS 497 +T VKT ++ Sbjct: 476 SFTNVKTFSLPWP 488 >4QGK-A nrPDB Length = 461 Score = 376 bits (967), Expect = e-104, Method: Composition-based stats. Identities = 119/439 (27%), Positives = 199/439 (45%), Gaps = 22/439 (5%) Query: 64 VKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDL 123 V+ RQAF G R+ R + L L +++ + T + + K N Y ++ Sbjct: 6 VRRVRQAFLSG---RSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEV 62 Query: 124 AGCIKTLRYCAGWADKIQGRTIPIDGNFFT-----YTRHEPIGVCGQIIPWNFPLVMLIW 178 + + + + P+ N T Y + +P+GV I WN+P V+ I Sbjct: 63 ITVLGEIDFMLENLPEWV-TAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQ 121 Query: 179 KIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMD 238 + A++ GN V++KP+E + TA +A L+ + + ++ G + Sbjct: 122 PLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQ--R 178 Query: 239 IDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYH 298 D + +TG+T VGK++ EAA K +L VTLELGGKSPC + D DLD G + + Sbjct: 179 FDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMN 237 Query: 299 QGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLI 358 GQ CIA I E S+ ++ V + E K++ G + I+ + +IL L+ Sbjct: 238 CGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL 296 Query: 359 ESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVI 418 EG K+ GG ++ PTV ++V + ++ +EEIFGP+ I+ K++D+ I Sbjct: 297 -----EGQKIAFGGET-DEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAI 350 Query: 419 KRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNC--YGVVSAQCPFGGFKMSGNGR 476 N L+ VF+ + + +G V N PFGG SG G Sbjct: 351 NFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGA 410 Query: 477 ELGEYGFHEYTEVKTVTVK 495 G++ F ++ + +K Sbjct: 411 YHGKHSFDTFSHQRPCLLK 429 >4OE4-A nrPDB Length = 580 Score = 368 bits (945), Expect = e-102, Method: Composition-based stats. Identities = 136/510 (26%), Positives = 230/510 (45%), Gaps = 43/510 (8%) Query: 23 IFINNEWH-DSVSGKKFPVFNPAT-EEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80 + IN E D+ FP NPA ++ L V + ++DV + A + A W + Sbjct: 62 LVINGERIYDNNERALFPQTNPANHQQVLANVTQATEKDV---MNAVKAAKDAKKDWYNL 118 Query: 81 DASERGRLLYKLADLIE-RDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADK 139 +R + K ADLI + R + + GK A ++ + RY +A Sbjct: 119 PFYDRSAIFLKAADLISTKYRYDMLAATMLGQGKNVYQAEIDCITELSDFFRYYVKYASD 178 Query: 140 IQGRTIPIDGNFFTYT--RHEPI-GVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAE 196 + + P++ T+ + P+ G + P+NF + PAL GNTVV KP++ Sbjct: 179 LYAQQ-PVESADGTWNKAEYRPLEGFVYAVSPFNFTAIAANLIGAPAL-MGNTVVWKPSQ 236 Query: 197 QTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKE 256 L+ + ++++EAG P GV+N +PG + + D + FTGST V K + Sbjct: 237 TAALSNYLLMTVLEEAGLPKGVINFIPGDPVQVTDQVLADKDFGALHFTGSTNVFKSLYG 296 Query: 257 A-------AGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRI 309 + R+ E GGK+ +V A++ +AV G F QGQ C AASR+ Sbjct: 297 KIQSGVVEGKYRDYPRIIGETGGKNFHLVHPSANISHAVLSTIRGTFEFQGQKCSAASRL 356 Query: 310 FVEESIYDEFVR------RSVERAKKYILGNPLTPGV---TQGPQIDKEQYDKILDLIES 360 ++ ES +EF+ +S +P++ G GP I ++ +DK++ +IE Sbjct: 357 YLPESKSEEFLSDMFGILQSQNVVPMNTSASPISGGNLRGFMGPVIHEQSFDKLVKVIED 416 Query: 361 GKKEG-AKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLD---- 415 KK+ ++ GG ++G+FV PTV + E FGP+ + ++ + Sbjct: 417 AKKDPELEILYGGQYDKSQGWFVGPTVIKAKRPDHPYMSTEFFGPILTVYEYPDTEFNEI 476 Query: 416 -DVIKRANNTFYGLSAGVFTKDIDKAITISSALQ--AGTVWVN--CYGVVSAQCPFGGFK 470 D+I N + Y L+ +F KD L+ AG ++N C G V +Q FGG + Sbjct: 477 CDIID--NTSQYALTGAIFAKDRKAIEYADEKLKFSAGNFYINDKCTGAVVSQQWFGGAR 534 Query: 471 MSGNGRELGEYGFHEYTEVKTVTVKISQKN 500 MSG + G + V+++ +++N Sbjct: 535 MSGTDDKAGGPNILS----RFVSIRNTKEN 560 >5UCD-A nrPDB Length = 457 Score = 357 bits (917), Expect = 5e-99, Method: Composition-based stats. Identities = 127/436 (29%), Positives = 203/436 (46%), Gaps = 22/436 (5%) Query: 66 AARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAG 125 +A++A+ T D R + L +L + + ++ L + + + GK L ++ Sbjct: 35 SAQKAYFATR--ATADVGFRKQSLERLKEAVINNKEALYSALAEDLGKPKDVVDLAEIGA 92 Query: 126 CIKTLRYCAGWADK-IQGRTIPIDG---NFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIG 181 + + + D+ + ++P Y EP GV I P+N+P+ + + + Sbjct: 93 VLHEIDFALAHLDEWVAPVSVPSPDIIAPSECYVVQEPYGVTYIIGPFNYPVNLTLTPLI 152 Query: 182 PALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDK 241 A+ GNT ++KP+E TP T+ + +I EA F P V ++ G +S D Sbjct: 153 GAIIGGNTCIIKPSETTPETSAVIEKIIAEA-FAPEYVAVIQGGRDENSHLLSLP--FDF 209 Query: 242 VAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQ 301 + FTGS VGK++ +AA K +L V LELGGK P IVL DADLD V G F + GQ Sbjct: 210 IFFTGSPNVGKVVMQAAAK-HLTPVVLELGGKCPLIVLPDADLDQTVNQLMFGKFINSGQ 268 Query: 302 CCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESG 361 IA ++V S+ D + R VER K L + G + + Q +++ L+E+ Sbjct: 269 TXIAPDYLYVHYSVKDALLERLVERVKTE-----LPEINSTGKLVTERQVQRLVSLLEA- 322 Query: 362 KKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRA 421 +G L G + TV V + EE+FGP+ +++F S+ I + Sbjct: 323 -TQGQVLV--GSQADVSKRALSATVVDGVEWNDPLMSEELFGPILPVLEFDSVRTAIDQV 379 Query: 422 NN-TFYGLSAGVFTKDIDKAITISSALQAGTVWVNCY--GVVSAQCPFGGFKMSGNGREL 478 N L+ VF KD+D A I + +Q+G VN S PFGG SG G Sbjct: 380 NKHHPKPLAVYVFGKDMDVAKGIINQIQSGDAQVNGVMLHAFSPYLPFGGIGASGMGEYH 439 Query: 479 GEYGFHEYTEVKTVTV 494 G + + +T K+V + Sbjct: 440 GHFSYLTFTHKKSVRI 455 >4H7N-A nrPDB Length = 474 Score = 349 bits (897), Expect = 1e-96, Method: Composition-based stats. Identities = 137/477 (28%), Positives = 216/477 (45%), Gaps = 37/477 (7%) Query: 36 KKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADL 95 K V NP T + + + + AR+A S W+ + R L + Sbjct: 6 KTIEVRNPRTGKFDYVIIPPPPRLLAQQCNRARRAQ---SRWQELGVEGRITTLQQWKQA 62 Query: 96 IERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ-----GRTIPIDGN 150 I R L + G+L + + ++ + ++ G A ++ +IP Sbjct: 63 ILSRREQLTEALVNDTGRL--SITVLEIDSFLASIDRWCGLAPELLQTSAKNTSIPFIAL 120 Query: 151 FFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP------LTALH 204 + P + G I PWNFPL + + PAL G VVVKP+E P L AL+ Sbjct: 121 QQSLV---PYPLVGVISPWNFPLTLSMIDTIPALLAGCAVVVKPSEIAPRFVAPLLMALN 177 Query: 205 VASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLK 264 +++ V+ V G G GA + ++ +D V FTGS G+ + E A + Sbjct: 178 TVPELRD------VLIFVEGGG-ETGANLINY--VDFVCFTGSVATGREVAETAAR-RFI 227 Query: 265 RVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSV 324 LELGGK P IVL A+L+ A G + GQ C++ RI+V ES ++EF + + Sbjct: 228 PAYLELGGKDPAIVLESANLELATSAILWGAVVNTGQSCLSIERIYVAESKFEEFYHQLI 287 Query: 325 ERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWG-NKGYFVQ 383 +A + L PL GP I ++Q I D I ++GA + CGG G++ + Sbjct: 288 AKAHRLQLAYPLVEDGAIGPIIAEKQAGIINDHILDAVEKGAVIHCGGKVEELGGGWWCR 347 Query: 384 PTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITI 443 PTV +NV M++ EE FGP+ +M F +++ + AN+T YGLSA VF D+A+ + Sbjct: 348 PTVMTNVNHSMKVMTEETFGPIMPVMPFPDVEEAVYLANDTIYGLSAAVFAGSEDEALKV 407 Query: 444 SSALQAGTVWVNCYGVVSAQCPFGGFKM----SGN-GRELGEYGFHEYTEVKTVTVK 495 + L AG + +N + + G K SG G +G G + + +K Sbjct: 408 ARQLNAGAISINDAALTAMMHE--GEKNAFNFSGLGGSRVGAAGLKRFLRKQAFLIK 462 >4IDS-A nrPDB Length = 563 Score = 330 bits (846), Expect = 1e-90, Method: Composition-based stats. Identities = 119/486 (24%), Positives = 190/486 (39%), Gaps = 20/486 (4%) Query: 23 IFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDA 82 I H G++ V P ++ A A A S W + Sbjct: 64 HVIGGR-HRMGDGERIDVVQPHRHA--ARLGTLTNATHADAAAAVEAAMSAKSDWAALPF 120 Query: 83 SERGRLLYKLADLIERD-RLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 ER + + ADL+ R +A + K A ++ + I R+ +A +I Sbjct: 121 DERAAVFLRAADLLAGPWREKIAAATMLGQSKSVYQAEIDAVCELIDFWRFNVAFARQIL 180 Query: 142 GRTIPIDGNFFTYTRHEPI-GVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200 + + + P+ G I P+NF + PAL GNTV+ KP+ L Sbjct: 181 EQQPISGPGEWNRIDYRPLDGFVYAITPFNFTSIAGNLPTAPAL-MGNTVIWKPSITQTL 239 Query: 201 TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAG- 259 A L++ AG PPGV+N+V G G + + + FTGST + + G Sbjct: 240 AAYLTMQLLEAAGLPPGVINLVTGDGFAVSDVALADPRLAGIHFTGSTATFGHLWQWVGT 299 Query: 260 ----KSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESI 315 + R+ E GGK + A A D G F +QGQ C A SR F+ S+ Sbjct: 300 NIGRYHSYPRLVGETGGKDFVVAHASARPDVLRTALIRGAFDYQGQKCSAVSRAFIAHSV 359 Query: 316 YDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGA-KLECGGGP 374 + + +A + G+ G ID+ + K +D IE K A + GG Sbjct: 360 WQRMGDELLAKAAELRYGDITDLSNYGGALIDQRAFVKNVDAIERAKGAAAVTVAVGGEY 419 Query: 375 WGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSL--DDVIKRANN-TFYGLSAG 431 ++GYFV+PTV + E FGP+ + + + ++ + + Y L+ Sbjct: 420 DDSEGYFVRPTVLLSDDPTDESFVIEYFGPLLSVHVYPDERYEQILDVIDTGSRYALTGA 479 Query: 432 VFTKDIDKAITISSALQ--AGTVWVNC--YGVVSAQCPFGGFKMSGNGRELG-EYGFHEY 486 V D +T L+ AG +VN G V + PFGG + S + G + Sbjct: 480 VIADDRQAVLTALDRLRFAAGNFYVNDKPTGAVVGRQPFGGARGSDTNDKAGSPLNLLRW 539 Query: 487 TEVKTV 492 T +++ Sbjct: 540 TSARSI 545 >5NNO-A nrPDB Length = 546 Score = 311 bits (796), Expect = 6e-85, Method: Composition-based stats. Identities = 110/454 (24%), Positives = 189/454 (41%), Gaps = 38/454 (8%) Query: 64 VKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDL 123 V R+AF D +R ++L L +L+E + + + + ++ Sbjct: 21 VSKCREAFNDD---ANRDLKKRKQVLRSLLNLVEENTDEFCKAIHRDRRRHRDETVVMEI 77 Query: 124 AGCIKTLRYCAGWADKIQGRTIPIDGNFFTY----TRHEPIGVCGQIIPWNFPLVMLIWK 179 + + D+ P ++EP+GV I WN+PL++++ Sbjct: 78 LPLRNEVWHLIEHMDEYVKPVKPTMEGAAALDDCELQYEPLGVVLVIGTWNYPLLLILQP 137 Query: 180 IGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDI 239 + AL+ GNT V+KP+E P TA + L+ + VV IV G A + Sbjct: 138 LLGALAAGNTAVIKPSELAPATAELLTKLLPKY-VSSDVVGIVNGGVSETTAVLKE--RF 194 Query: 240 DKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADA--DLDNAVEFAHHGVFY 297 D + +TGS V +++ AA K +L VTLELGGKSP +V ++ E G Sbjct: 195 DHILYTGSARVAEIVMAAAAK-HLTPVTLELGGKSPVVVDDTCADNMKVVAERIMWGKII 253 Query: 298 HQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLT----------------PGVT 341 + GQ IA + VE+S+ V E K LG+ Sbjct: 254 NAGQTSIAPDYVVVEKSMESVLVDALAEARKAM-LGDKFLKVLKGELLVKQKQQFLEESD 312 Query: 342 QGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEI 401 ++ + ++++ + +G K+ GG + PT+ +N+ + +EEI Sbjct: 313 YPRIVNASHFQRLMEFM-----KGGKVAVGGEA-DEATLTIAPTILTNIDPTHPVMQEEI 366 Query: 402 FGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVS 461 FGP+ ++ +++ D++K N+ L+ VF+ + + S +G V VN V + Sbjct: 367 FGPILPVLTYENEKDILKIINSREKPLALYVFSNNKRFIRGVESRTSSGAVVVNDVVVHA 426 Query: 462 AQ--CPFGGFKMSGNGRELGEYGFHEYTEVKTVT 493 PFGG SG G G Y F ++ + V Sbjct: 427 GADGLPFGGVGRSGMGAYHGRYSFETFSHRRPVM 460 >2Y53-A nrPDB Length = 534 Score = 253 bits (648), Expect = 1e-67, Method: Composition-based stats. Identities = 107/462 (23%), Positives = 178/462 (38%), Gaps = 42/462 (9%) Query: 19 QYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWR 78 + K + +W +G + +P T L +V D+ +A AR+ G+ R Sbjct: 6 ELLKNHVAGQWIAG-TGAGITLTDPVTGVALVRVSSEGL-DLARAFSFARE--DGGAALR 61 Query: 79 TMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWAD 138 + ++R L + L++ R + + N G +++ + D+ G I TL Y A Sbjct: 62 ALTYAQRAARLADIVKLLQAKRGDYYAIATANSGTTRNDSAV-DIDGGIFTLSYYAKLGA 120 Query: 139 KIQ---------GRTIPIDGNFFTYTRHEPI-GVCGQIIPWNFPLVMLIWKIGPALSCGN 188 + ++ D +F P GV I +NFP L K PAL G Sbjct: 121 SLGEVHALRDGSAESLSKDRSFSAQHVLSPTRGVALFINAFNFPSWGLWEKAAPALLSGV 180 Query: 189 TVVVKPAEQTP-LTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGS 247 V+VKPA T LT VA ++ PPG ++I+ G + D V+FTGS Sbjct: 181 PVIVKPATATAWLTQRMVADVVDAGILPPGALSIICGSSA---GLLDQIRSFDVVSFTGS 237 Query: 248 TEVGKLI-KEAAGKSNLKRVTLELGGKSPCIVLADADLDNAV-----EFAHHGVFYHQGQ 301 + + A R+ ++ + I+ ADA D + + GQ Sbjct: 238 ADTAATLRAHPAFVQRGARLNVQADSLNSAILCADATPDTPAFDLFIKEVVREMTVKSGQ 297 Query: 302 CCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESG 361 C A R FV E+ + + + K +GNP V G + +EQY+ +L I + Sbjct: 298 KCTAIRRAFVPEAALEPVLEALKAKLAKITVGNPRNDAVRMGSLVSREQYENVLAGIAAL 357 Query: 362 KKEGAKLECGGGPW------GNKGYFVQPTVF-SNVTDEMRIAKE-EIFGPVQQIMKFKS 413 ++E A L N V P +F N D + + E+FGPV + ++ Sbjct: 358 REE-AVLAYDSSAVPLIDADANIAACVAPHLFVVNDPDNATLLHDVEVFGPVASVAPYRV 416 Query: 414 --------LDDVIKRANNTFYGLSAGVFTKDIDKAITISSAL 447 + A L A +++ D ++ L Sbjct: 417 TTDTNALPEAHAVALARRGQGSLVASIYSNDDAHLGRLALEL 458 >3V4C-A nrPDB Length = 528 Score = 247 bits (630), Expect = 1e-65, Method: Composition-based stats. Identities = 107/472 (22%), Positives = 164/472 (34%), Gaps = 51/472 (10%) Query: 19 QYTKIFINNEWHDSV-SGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPW 77 K + EW D + P PA + + V E V++A +AA +AF Sbjct: 28 PKGKHLVAGEWLDGAGTFASAPAHGPAHDFAVGTV-----ELVNRACEAAEEAFWTYG-- 80 Query: 78 RTMDASERGRLLYKLADLIERDRLLLATMESMNGGKL---------YSNAYLNDLAGCIK 128 ER L +AD IE + + S G + L A I+ Sbjct: 81 -YSSRKERAAFLRAIADEIEARAEAITEIGSQETGLPEARLNGERGRTTGQLRLFADHIE 139 Query: 129 TLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLI--WKIGPALSC 186 Y D P + P+G NFPL AL+ Sbjct: 140 KGDYLDRRVDAAMPERQPAPRQEIRLVQR-PVGPVAVFGASNFPLAFSTAGGDTAAALAA 198 Query: 187 GNTVVVKPAEQTPLTALHVASLIKEA----GFPPGVVNIVPGYGPTAGAAISSHMDIDKV 242 G VVVK P T VA + A G PGV +++ G G A+ H I V Sbjct: 199 GCPVVVKGHSAHPGTGEIVAEAVDAAIRKTGVHPGVFSLIQGGSRDVGHALVQHPHIKAV 258 Query: 243 AFTGSTEVGKLIKE-AAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHG----VFY 297 FTGS G+ + + A + ELG +P +L +A L E G + Sbjct: 259 GFTGSLAGGRALFDLCAARPEPIPFFGELGSVNPMFLLPEA-LKARAETLGQGWAGSLTM 317 Query: 298 HQGQCCIAAS-RIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILD 356 GQ C + +E + D F +VE K LT G+ + + + ++ Sbjct: 318 GAGQFCTNPGIAVVIEGADADRFTTAAVEALAKVAPQTMLTDGIAKAYRDGQARFA---- 373 Query: 357 LIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDE---MRIAKEEIFGPVQQIMKFKS 413 + K E G P +F + EE+FGP+ +++ S Sbjct: 374 -TRNAVKPLLATESSGRDAS-------PNLFETTGAQFLADHALGEEVFGPLGLVVRVGS 425 Query: 414 LDDVIKRANNTFYGLSAGVFTK--DIDKAITISSALQ--AGTVWVNCYGVVS 461 ++ + A L+A + D++ A + L+ AG V VN + Sbjct: 426 PAEMEELARGFQGQLTATIHMDAGDLETARRLRPVLERKAGRVLVNGFPTGV 477 >5DBV-A nrPDB Length = 445 Score = 229 bits (585), Expect = 2e-60, Method: Composition-based stats. Identities = 102/462 (22%), Positives = 171/462 (37%), Gaps = 64/462 (13%) Query: 58 EDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGG----- 112 +D+++A++AA++A + + M +R +++ + LA M G Sbjct: 16 DDMNQAIEAAKEAQLVV---KKMSMDQREKIISAIRKKTIEHAETLARMAVEETGMGNVG 72 Query: 113 -KLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNF 171 K+ + + + + + A D+ T P GV G I P Sbjct: 73 HKILKHQLVAEKTPGTEDITTTAWSGDR-----------GLTLVEMGPFGVIGAITPCTN 121 Query: 172 PLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPP-GVVNIVPGYGP--- 227 P +I L+ GNTVV P T+ LI EA G VNI Sbjct: 122 PSETIICNTIGMLAGGNTVVFNPHPAAIKTSNFAVQLINEASLSAGGPVNIACSVRKPTL 181 Query: 228 TAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNA 287 + + SH DI +A TG V + + + KR G P +V AD+ A Sbjct: 182 DSSKIMMSHQDIPLIAATGGPGVVTAVLQ-----SGKRGIGAGAGNPPVLVDETADIRKA 236 Query: 288 VEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQID 347 E +G + IA + ++I +E + V+ Y I Sbjct: 237 AEDIINGCTFDNNLPAIAEKEVVAIDAIANELMNYMVKEQGCYA--------------IT 282 Query: 348 KEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVT-------DEMRIAKEE 400 KEQ +K+ +L+ + K G C G + V SN+ E + EE Sbjct: 283 KEQQEKLTNLVITPK--GLNRNCVGKDARTLLGMIGIDVPSNIRCIIFEGEKEHPLISEE 340 Query: 401 IFGPVQQIMKFKSLDDVIKRANNTFYG--LSAGVFTKDIDKAITISSALQAGTVWVNCYG 458 + P+ I++ KS DD +++A +G SA + +K++D+ T + A+ + N Sbjct: 341 LMMPILGIVRAKSFDDAVEKAVWLEHGNRHSAHIHSKNVDRITTYAKAIDTAILVKN--A 398 Query: 459 VVSAQCPFGGFK------MSGNGRELGEYGFHEYTEVKTVTV 494 A FGG S G G +T+ + + Sbjct: 399 PSYAAIGFGGEGFCTFTIASRTGE--GLTSASTFTKRRRCVM 438 >6D97-A nrPDB Length = 547 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 94/474 (19%), Positives = 176/474 (37%), Gaps = 43/474 (9%) Query: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81 + F+ W S + +P ++ +V E ++ +++ + + G + Sbjct: 46 QNFVQGSWTASANWNWI--VDPLNGDKFIKVAEVQGTEIKSFMESLSKCPKHGLH-NPLK 102 Query: 82 ASER----GRLLYKLADLIERDR--LLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAG 135 A ER G + K A ++ + A + K Y A L ++ K L G Sbjct: 103 APERYLMYGDISAKAAHMLGQPTVLDFFAKLIQRVSPKSYQQA-LAEVQVSQKFLENFCG 161 Query: 136 WADKIQGRTIPIDGNFFTYT---RHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVV 192 + R+ + GN P G I P+NFPL + + ++ AL GN V+ Sbjct: 162 DQVRFLARSFAVPGNHLGQRSNGYRWPYGPVAIITPFNFPLEIPLLQLMGALYMGNKPVL 221 Query: 193 KPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGK 252 K + + + L+ + G P ++ + G + + FTGS+ V + Sbjct: 222 KVDSKVSIVMEQMIRLLHDCGLPAEDMDFINSDGAVMNKLLLE-ANPKMTLFTGSSRVAE 280 Query: 253 LIKEAAGKSNLK-RVTLELGGKSPCIVLADA-DLDNAVEFAHHGVFYHQGQCCIAASRIF 310 + ++LK RV LE G I+ D ++D + GQ C A S +F Sbjct: 281 KLA-----ADLKGRVKLEDAGFDWKILGPDVQEVDYVAWVCDQDAYACSGQKCSAQSVLF 335 Query: 311 VEESIYDE-FVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLE 369 + ++ + + + +++ L +T GP + I + K G+K+ Sbjct: 336 MHKNWSSSGLLEKMKKLSERRKL-----EDLTIGPVLTVTTEAMIEHMNNLLKIRGSKVL 390 Query: 370 CGGGPWGNKGY-----FVQPT-VFSNVTD-----EMRIAKEEIFGPVQQIMKF--KSLDD 416 GG P N ++PT VF + + + +EIFGP Q + ++ L+ Sbjct: 391 FGGEPLANHSIPKIYGAMKPTAVFVPLEEILKSGNFELVTKEIFGPFQVVTEYSEDQLEL 450 Query: 417 VIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNC---YGVVSAQCPFG 467 V++ L+A + + D + GT + FG Sbjct: 451 VLEACERMNAHLTAAIVSNDPLFLQDVLGRSVNGTTYAGIRARTTGAPQNHWFG 504 >1EZ0-A nrPDB Length = 510 Score = 208 bits (531), Expect = 3e-54, Method: Composition-based stats. Identities = 92/458 (20%), Positives = 161/458 (35%), Gaps = 44/458 (9%) Query: 31 DSVSGKKFPVFNPATEEEL-CQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLL 89 + + F N T E L + +V+ +AA A ++ +R ++ S+R LL Sbjct: 2 NPQTDNVFYATNAFTGEALPLAFPVHTEVEVN---QAATAAAKVARDFRRLNNSKRASLL 58 Query: 90 YKLA--------DLIERDRLLLATMESMNGGKLYSNA-YLNDLAGCIKTLRYCAGWADKI 140 +A D+I R L A E G++ A L A + + Y D Sbjct: 59 RTIASELEARSDDIIARAHLETALPEVRLTGEIARTANQLRLFADVVNSGSYHQAILDTP 118 Query: 141 QGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLI--WKIGPALSCGNTVVVKPAEQT 198 P+ + +G NFPL AL+ G V+VK Sbjct: 119 NPTRAPLPKPDIR-RQQIALGPVAVFGASNFPLAFSAAGGDTASALAAGCPVIVKGHTAH 177 Query: 199 PLTALHVASLIKEA----GFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLI 254 P T+ VA I++A P + ++ G G A+ SH +I V FTGS G+ + Sbjct: 178 PGTSQIVAECIEQALKQEQLPQAIFTLLQGNQRALGQALVSHPEIKAVGFTGSVGGGRAL 237 Query: 255 KEAAG-KSNLKRVTLELGGKSPCIVLADADLDNA--VEFAHHGVFYHQGQCCIAASRIFV 311 A + ELG +P + A A + + GQ C +F Sbjct: 238 FNLAHERPEPIPFYGELGAINPTFIFPSAMRAKADLADQFVASMTMGCGQFCTKPGVVFA 297 Query: 312 EESIY-DEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLEC 370 + F+ + ++ +P P I ++ + G +G + Sbjct: 298 LNTPETQAFIETAQSLIRQQ------SPSTLLTPGIRDSYQSQV---VSRGSDDGIDVTF 348 Query: 371 GGGPWGNKGYFVQPTVFSNVTDE---MRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYG 427 + V +F ++ +EEIFGP I+ +++ D++ + Sbjct: 349 SQA----ESPCVASALFVTSSENWRKHPAWEEEIFGPQSLIVVCENVADMLSLSEMLAGS 404 Query: 428 LSAGVFTK--DIDKAITISSALQ--AGTVWVNCYGVVS 461 L+A + D + + L+ AG + N + Sbjct: 405 LTATIHATEEDYPQVSQLIPRLEEIAGRLVFNGWPTGV 442 >5JFN-A nrPDB Length = 524 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 80/413 (19%), Positives = 142/413 (34%), Gaps = 54/413 (13%) Query: 81 DASERGRLLYKLADLIERDR--LLLATMESMNGG------KLYSNAYLNDLAGCIKTLRY 132 S+R R + + D+I ++ M G KL N + I+ L Sbjct: 112 SMSDRARFVQGIRDVILNQDTLEKMSRMAVEETGMGNYEHKLIKNRLAGEKTPGIEDLTT 171 Query: 133 CAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVV 192 A D N T + P GV G I P P ++ L+ GN+VV Sbjct: 172 DAFSGD-----------NGLTLVEYSPFGVIGAITPTTNPTETIVCNSIGMLAAGNSVVF 220 Query: 193 KPAEQTPLTALHVASLIKEA----GFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGST 248 P + +L + LI + G P +V V A+ +H + + TG Sbjct: 221 SPHPRARQVSLLLVRLINQKLAALGAPENLVVTVEKPSIENTNAMMAHPKVRMLVATGGP 280 Query: 249 EVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASR 308 + K + S K+ G P +V A+++ A +G + +A Sbjct: 281 AIVKAVL-----STGKKAIGAGAGNPPVVVDETANIEKAACDIVNGCSFDNNLPXVAEKE 335 Query: 309 IFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKL 368 I I D + ++ Y + +P ++ DL+ + K G + Sbjct: 336 IIAVAQIADYLIFNL-KKNGAYEIKDPAV-------------LQQLQDLVLTAKG-GPQT 380 Query: 369 ECGGGP----WGNKGYFVQPT---VFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRA 421 +C G G V + + V E +EE+ P+ +++ +++DD I A Sbjct: 381 KCVGKSAVWLLSQIGISVDASIKIILMEVPREHPFVQEELMMPILPLVRVETVDDAIDLA 440 Query: 422 NNTFYG--LSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMS 472 + +A + + D+ K ++ +Q N GG S Sbjct: 441 IEVEHDNRHTAIMHSTDVRKLTKMAKLIQTTIFVKNGPSYAGLGA--GGEGYS 491 >3MY7-A nrPDB Length = 452 Score = 178 bits (452), Expect = 5e-45, Method: Composition-based stats. Identities = 70/433 (16%), Positives = 141/433 (32%), Gaps = 38/433 (8%) Query: 52 VEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNG 111 + + ++D + ++A + + + + + + + R+ LA Sbjct: 1 MPVTNMAELDAMIARVKKAQEEFATYSQEQVDK---IFRAASLAANQARIPLAQQAVEES 57 Query: 112 GKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNF 171 G + + + + D+ + D N T T EP+G+ I+P Sbjct: 58 GMGIVEDKVIKNHFASEFI--YNKYKDEQTCGILEEDDNLGTMTIAEPVGIICGIVPTTN 115 Query: 172 PLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEA----GFPPGVVNIVPGYGP 227 P I+K +L N ++ P + + A L+ +A G P ++ + Sbjct: 116 PTSTAIFKSLISLKTRNGIIFSPHPRAKNSTNDAAKLVLDAAVAAGAPKDIIGWIDQPSV 175 Query: 228 TAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNA 287 A+ H DI + TG A S+ K G P ++ AD+ A Sbjct: 176 ELSNALMKHDDIALILATGGPG-----MVKAAYSSGKPAIGVGAGNVPVVIDETADIKRA 230 Query: 288 VEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQID 347 V + G C + + V + +YDE R + ID Sbjct: 231 VASVLMSKTFDNGVVCASEQAVIVVDEVYDEVKERFASHKAHVLSKTDADKVRKV-LLID 289 Query: 348 KEQYDKILDLIESGKKE--GAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPV 405 KI+ + E G K+ +G V+ + A E++ P Sbjct: 290 GALNAKIVGQPATAIAEMAGVKVPADTKVLIGEG-------LGKVSYDDAFAHEKL-SPT 341 Query: 406 QQIMKFKSLDDVIKRANNTF----YGLSAGVFTK---DIDKAITISSALQAGTVWVNCYG 458 + + + +D + +A G ++G++T + D+ ++ + +N Sbjct: 342 LGMFRADNFEDAVAQAVTMVEIGGIGHTSGLYTNQDVNADRIRYFGDKMKTARILINIPT 401 Query: 459 VVSAQCPFGGFKM 471 GG Sbjct: 402 T------HGGIGD 408 >5J7I-A nrPDB Length = 488 Score = 167 bits (423), Expect = 1e-41, Method: Composition-based stats. Identities = 79/443 (17%), Positives = 148/443 (33%), Gaps = 50/443 (11%) Query: 47 EELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATM 106 L ++ ++V ++ A+ A +I M SE +++ +A+ + LA M Sbjct: 23 SMLRDIDLQSIQEVRNYLEEAKAAQKILE---KMTQSEIDKIVESMANAAREEAGRLAAM 79 Query: 107 ESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQI 166 G + + I D + +P+G+ I Sbjct: 80 AVEETGFGNVEDKTLKNLFAANDVYNSIKDVKTVG--IIRRDEENRVWEIAQPVGIVAGI 137 Query: 167 IPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEA----GFPPGVVNIV 222 IP P +I+K A+ N +V P A +++EA G P G+++ + Sbjct: 138 IPSTNPTSTVIFKALIAVKARNAIVFSPHPSAAKCTAEAARIMQEAAERAGAPKGLISCI 197 Query: 223 PGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADA 282 A + H D + TG + K A S+ K G P + A Sbjct: 198 TQPTMAATNELMKHKLTDVILATGGPGLVK-----AAYSSGKPAYGVGPGNVPVYIHESA 252 Query: 283 DLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQ 342 ++ AV+ + G C + + V+ESI ++ V ++ Sbjct: 253 NIAKAVQLIIQSKTFDYGTICASEQALLVDESIKEKVVAELKQQGA-------------- 298 Query: 343 GPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVT----DEMRIAK 398 +++E+ K+ +I AK+ G + S+V +E + K Sbjct: 299 -YFLNEEEKQKVASIIMVNGSLNAKIV--GKAPQVIAEMAGIEIPSDVKLLVAEETEVGK 355 Query: 399 EEIF-----GPVQQIMKFKSLDDVIKRANNT----FYGLSAGVFTKDIDKAITISSALQA 449 E F P+ K +++ + A G + G+ +D + A Sbjct: 356 EYPFSIEKLSPILAFYIVKGMEEASELAQKLLEVGGLGHTVGIHAEDEKVIEAYTIDKPA 415 Query: 450 GTVWVNCYGVVSAQCPFGGFKMS 472 G + VN FGG + Sbjct: 416 GRIVVNAGTT------FGGIGAT 432 >3K9D-A nrPDB Length = 464 Score = 149 bits (376), Expect = 4e-36, Method: Composition-based stats. Identities = 69/433 (15%), Positives = 133/433 (30%), Gaps = 47/433 (10%) Query: 56 DKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLY 115 ++V +++A +A + M + ++ +AD R LA M G Sbjct: 10 SIQEVRNLIESANKAQK---ELAAMSQQQIDTIVKAIADAGYGAREKLAKMAHEETGFGI 66 Query: 116 SNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVM 175 + K + I + D P+GV +IP P Sbjct: 67 WQDKVIKNVFASKHVYNYIKDMKTIG--MLKEDNEKKVMEVAVPLGVVAGLIPSTNPTST 124 Query: 176 LIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEA----GFPPGVVNIVPGYGPTAGA 231 +I+K ++ GN++V P L +I EA G P G ++ + Sbjct: 125 VIYKTLISIKAGNSIVFSPHPNALKAILETVRIISEAAEKAGCPKGAISCMTVPTIQGTD 184 Query: 232 AISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFA 291 + H D + TG + A S+ G P + A++ AV+ Sbjct: 185 QLMKHKDTAVILATGGSA-----MVKAAYSSGTPAIGVGPGNGPAFIERSANIPRAVKHI 239 Query: 292 HHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVER-------AKKYILGN-PLTPGVTQG 343 + G C + + VE + + ++ A+ LG L P + Sbjct: 240 LDSKTFDNGTICASEQSVVVERVNKEAVIAEFRKQGAHFLSDAEAVQLGKFILRPNGSMN 299 Query: 344 PQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFG 403 P I + I +L A++ G + E Sbjct: 300 PAIVGKSVQHIANLAGLTVPADARVLI--AEETKVGAKIP-------------YSREKLA 344 Query: 404 PVQQIMKFKSLDDVIKRANNTFY----GLSAGVFTKDIDKAITISSALQAGTVWVNCYGV 459 P+ ++ + + + + Y G + + ++D + + + VN G Sbjct: 345 PILAFYTAETWQEACELSMDILYHEGAGHTLIIHSEDKEIIREFALKKPVSRLLVNTPGA 404 Query: 460 VSAQCPFGGFKMS 472 + GG + Sbjct: 405 L------GGIGAT 411 >5UJU-A nrPDB Length = 576 Score = 147 bits (372), Expect = 1e-35, Method: Composition-based stats. Identities = 97/474 (20%), Positives = 163/474 (34%), Gaps = 56/474 (11%) Query: 35 GKKFPVFNPATEEELC--QVEEGDKEDVDKAVKAARQAF-----QIGSPWRTMDASERGR 87 GK F + PA+ E + + G D+ K+ A WR S Sbjct: 63 GKTFELDQPASGETVGAERSPYGVALDIRYP-KSTPDALIAAAAAAQRTWREAGPSAWIG 121 Query: 88 LLYKLADLIERDRLLLAT----------MESMNGGKLYSNAYLND-LAGCIKTLRYCAGW 136 + ++ + R +A M + G ++ + +A LR Sbjct: 122 VSLEILARLNRASFEIAYSVMHTTGQAFMMAFQAGGPHAQDRALEAVAYAWDQLRRIPAD 181 Query: 137 A--DKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKP 194 A +K QG+ P+ G+ FP + L+ GNTV+VKP Sbjct: 182 AHWEKPQGKNPPLAMQKRYTIVPRGTGLVLGC--CTFPTWNGYPGLFADLATGNTVIVKP 239 Query: 195 AEQTPL----TALHVASLIKEAGFPPGVVNIV---PGYGPTAGAAISSHMDIDKVAFTGS 247 L T +++EAGF P VV ++ P G ++ +I + FTGS Sbjct: 240 HPGAILPLAITVRIARDVLREAGFDPNVVTLLATEPNDGALV-QDLALRPEIKLIDFTGS 298 Query: 248 TEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAAS 307 T+ G ++ A ++ +V E G + ++ + DL A + + + GQ C A Sbjct: 299 TQNGTWLERHAHQA---QVYTEKAGVNQIVIDSTDDLKAAAKNIAFSLALYSGQMCTAPQ 355 Query: 308 RIFVEE---------SIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLI 358 I+V + +DE + +K G+P G Q D + I Sbjct: 356 NIYVPRDGIRTADGHASFDEVAQAIAGAVQKLT-GDPARSVELIGAI----QNDGVTARI 410 Query: 359 ESGKKEGAKLE---CGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLD 415 ++ + G L P P V + +E FGP+ ++ S Sbjct: 411 DAARAVGRVLLDSQTLQHPAFPDARVRTPLVLQLDVADREKFTQEWFGPISFVIATDSTA 470 Query: 416 DVIKRANN--TFYG-LSAGVFTKDIDKAITISSALQAGTV--WVNCYGVVSAQC 464 + A +G L+ V++ D A G V +N G V Sbjct: 471 QSLDLAGEIAAEHGALTLSVYSTADDVIDAAHEAAVRGGVALSINLTGGVFVNQ 524 >1O20-A nrPDB Length = 427 Score = 112 bits (281), Expect = 3e-25, Method: Composition-based stats. Identities = 87/466 (18%), Positives = 148/466 (31%), Gaps = 91/466 (19%) Query: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGK----LYS 116 D+ ++ A++ + R E+ + + K+A+ ++ R + ++ K Sbjct: 14 DELLEKAKKVREAWDVLRNATTREKNKAIKKIAEKLDERRKEILEANRIDVEKARERGVK 73 Query: 117 NAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTR---------HEPIGVCGQI- 166 + ++ LA K + + + G P+ ++ R PIG G I Sbjct: 74 ESLVDRLALNDKRIDEMIKACETVIGLKDPVGEVIDSWVREDGLRIARVRVPIGPIGIIY 133 Query: 167 --IPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEA----GFPPGVVN 220 P + + AL GNT++++ + + S I+EA P V Sbjct: 134 ESRP-----NVTVETTILALKSGNTILLRGGSDALNSNKAIVSAIREALKETEIPESSVE 188 Query: 221 IV-PGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELG-GKSPCIV 278 + I + V G + + N LE G G V Sbjct: 189 FIENTDRSLVLEMIRLREYLSLV-----IPRGGYGLISFVRDNATVPVLETGVGNCHIFV 243 Query: 279 LADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTP 338 ADL AV + G C AA ++ V E I EF+ Sbjct: 244 DESADLKKAVPVIINAKTQRPG-TCNAAEKLLVHEKIAKEFL------------------ 284 Query: 339 GVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAK 398 P I +E +K G ++ K + P V D+ Sbjct: 285 -----PVI-----------VEELRKHGVEV-----RGCEKTREIVPDVVPATEDDWP--- 320 Query: 399 EEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYG 458 E + I K++D+ I+ G S + T++ A S + A V+VN Sbjct: 321 TEYLDLIIAIKVVKNVDEAIEHIKKYSTGHSESILTENYSNAKKFVSEIDAAAVYVNAST 380 Query: 459 VVSAQCPFGGFKMSGNGREL----------GEYGFHEYTEVKTVTV 494 + F G G E+ G G E T K V + Sbjct: 381 RFTDGGQF------GFGAEIGISTQRFHARGPVGLRELTTYKFVVL 420 >4GHK-A nrPDB Length = 444 Score = 97.6 bits (242), Expect = 1e-20, Method: Composition-based stats. Identities = 81/436 (18%), Positives = 129/436 (29%), Gaps = 78/436 (17%) Query: 87 RLLYKLADLIERDRLLLATMESMNGG----KLYSNAYLNDLAGCIKTLRYCAGWADKIQG 142 L +A IERD L + + K A+++ L K L+ ++ Sbjct: 52 AALEAVARAIERDAGALKAANARDVARAKDKGLDAAFVDRLTLSDKALKTMVEGLRQVAT 111 Query: 143 RTIPI---------DGNFFTYTRHEPIGVCGQI---IPWNFPLVMLIWKIGPALSCGNTV 190 PI P+GV G I P + I L GN Sbjct: 112 LPDPIGEMSNLKYRPSGIQVGQMRVPLGVIGIIYESRP-----NVTIDAAALCLKSGNAT 166 Query: 191 VVKPAEQTPLTALHVASLI----KEAGFPPGVVNIV-PGYGPTAGAAISSHMDIDKVAFT 245 +++ + + +A LI EAG P V +V G I+ +D + Sbjct: 167 ILRGGSEALESNTALAKLIGEGLAEAGLPQDTVQVVETADRAAVGRLITMTEYVDVIV-- 224 Query: 246 GSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIA 305 GK + E + L G V A + A+ + + G C Sbjct: 225 --PRGGKSLIERLINEARVPMIKHLDGICHVYVDDRASVTKALTVCDNAKTHRYG-TCNT 281 Query: 306 ASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEG 365 + V I + G ++ + +D E Sbjct: 282 METLLVARGIAPAVLSPL-------------------GRLYREKGVELRVDADARAVLEA 322 Query: 366 AKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTF 425 A V P + TDE + E PV I +D I+ N Sbjct: 323 AG--------------VGP--LVDATDED--WRTEYLAPVLAIKIVDGIDAAIEHIN--E 362 Query: 426 YG--LSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFG-----GFKMSGNGREL 478 YG + + T+D D+A+ + + +V VN + FG G Sbjct: 363 YGSHHTDAIVTEDHDRAMRFLREVDSASVMVNASTRFADGFEFGLGAEIGISNDKLHAR- 421 Query: 479 GEYGFHEYTEVKTVTV 494 G G T +K V + Sbjct: 422 GPVGLEGLTSLKYVVL 437 >1VLU-A nrPDB Length = 468 Score = 75.6 bits (185), Expect = 4e-14, Method: Composition-based stats. Identities = 67/447 (14%), Positives = 134/447 (29%), Gaps = 83/447 (18%) Query: 65 KAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATM------ESMNGG------ 112 + A+ A + G+ +T+ R +LYK+ D ++ + + + G Sbjct: 18 QIAKNARKAGNILKTISNEGRSDILYKIHDALKANAHAIEEANKIDLAVAKETGLADSLL 77 Query: 113 KLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIP--IDGNFFTYTRHEPIGVCGQIIPWN 170 K + ++ ++ A D + + +D Y P+GV I + Sbjct: 78 KRLDLFKGDKFEVMLQGIKDVAELEDPVGKVKMARELDDGLTLYQVTAPVGVLLVI--FE 135 Query: 171 FPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIK--------EAGFPPGVVNIV 222 ++ ++ GN ++K +++ T +A ++ E G P G V ++ Sbjct: 136 SRPEVIANITALSIKSGNAAILKGGKESVNTFREMAKIVNDTIAQFQSETGVPVGSVQLI 195 Query: 223 PGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADA 282 + ID V GS + + IK+ + V G + DA Sbjct: 196 E-TRQDVSDLLDQDEYIDLVVPRGSNALVRKIKD----TTKIPVLGHADGICSIYLDEDA 250 Query: 283 DLDNAVEFAHHGVFYH-QGQCCIAASRIFVEE--SIYDEFVRRS-------VERAKKYIL 332 DL A + + G C A + + S + E + + K Sbjct: 251 DLIKAKRISLDAKTNYPAG--CNAMETLLINPKFSKWWEVLENLTLEGGVTIHATKDLKT 308 Query: 333 GNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTD 392 G + Q TV ++ Sbjct: 309 AY-FDKLNELGKLTEAIQCK--------------------------------TVDADEEQ 335 Query: 393 EMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTV 452 + +E S + I+ N + + T++ A + + V Sbjct: 336 D---FDKEFLSLDLAAKFVTSTESAIQHINTHSSRHTDAIVTENKANAEKFMKGVDSSGV 392 Query: 453 WVNCYGVVSAQCPFGGFKMSGNGRELG 479 + N + GF+ G G E+G Sbjct: 393 YWNASTRFAD-----GFRY-GFGAEVG 413 >2H5G-A nrPDB Length = 463 Score = 73.7 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 77/460 (16%), Positives = 132/460 (28%), Gaps = 101/460 (21%) Query: 70 AFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKT 129 A G T++ +R +++ LADL+ R + + K A A +K Sbjct: 38 ARSGGRMLATLEPEQRAEIIHHLADLLTDQRDEI----LLANKKDLEEAEGRLAAPLLKR 93 Query: 130 LRY-------CAGWADKIQGRTIPIDGNFFTYTR----------HEPIGVCGQIIPWNF- 171 L A +I + G TR PIGV I F Sbjct: 94 LSLSTSKLNSLAIGLRQIAASSQDSVGRVLRRTRIAKNLELEQVTVPIGVLLVI----FE 149 Query: 172 --PLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEA----GFPPGVVNIVPGY 225 P + A++ GN +++K ++ + + L +EA G V +V Sbjct: 150 SRPDCLP-QVAALAIASGNGLLLKGGKEAAHSNRILHLLTQEALSIHGV-KEAVQLVN-T 206 Query: 226 GPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLD 285 ID + GS+++ + I++AA V G V ++A +D Sbjct: 207 REEVEDLCRLDKMIDLIIPRGSSQLVRDIQKAA---KGIPVMGHSEGICHMYVDSEASVD 263 Query: 286 NAVEFAHHGVFYHQGQCCIAASRIFVEES-----IYDEFVRRSVERAKKYILGNPLTPGV 340 + C A + + ++D+ + K G + Sbjct: 264 KVTRLVRDSKCEYPA-ACNALETLLIHRDLLRTPLFDQIIDMLRVEQVKIHAGPKFASYL 322 Query: 341 TQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEE 400 T P ++S + E LE Sbjct: 323 TFSP-----------SEVKSLRTEYGDLE------------------------------- 340 Query: 401 IFGPVQQIMKFKSLDDVIKRANNTFYG--LSAGVFTKDIDKAITISSALQAGTVWVNCYG 458 I ++ D I YG + + T+D + A + + V+ N Sbjct: 341 -----LCIEVVDNVQDAIDHI--HKYGSSHTDVIVTEDENTAEFFLQHVDSACVFWNAST 393 Query: 459 VVSAQCPFG-----GFKMSGNGRELGEYGFHEYTEVKTVT 493 S FG G S G G K + Sbjct: 394 RFSDGYRFGLGAEVGISTSRIHAR-GPVGLEGLLTTKWLL 432 >4JBE-A nrPDB Length = 445 Score = 71.0 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 76/447 (17%), Positives = 133/447 (29%), Gaps = 83/447 (18%) Query: 53 EEGDKEDVDKAVKA-ARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNG 111 +V KAV+ AR A + L +AD + R + + + Sbjct: 30 SNAMTNEVAKAVEECARAAKSAAPSLSGAPDTAIDAALESMADRLLAHRDAVLAANAEDI 89 Query: 112 GK--------------LYSNAYLNDLAGCIKTLRYCAGWA-DKIQGRTIPIDGNFFTYTR 156 K + + L D LR AG + +DG R Sbjct: 90 AKAEAGGMSAGLLDRLTITESRLTD---MADQLRLLAGAPHPQRTVELSTLDGGLRLVER 146 Query: 157 HEPIGVCGQIIPWNFPL--VMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASL-----I 209 P+GV G N+ + + + N V++ +A + + + Sbjct: 147 RRPVGVIGA----NYEARPNVTVDVASQLVKSRNAGVLRTGSAALKSAQRLLEVVIRPAL 202 Query: 210 KEAGFPPGVVNIVPGYGPTAGAAISSHMD-IDKVAFTGSTEVGKLIKEAAGKSNLKRVTL 268 ++G VV +VP A A+ D + V GS E + + A + ++ + Sbjct: 203 TDSGIDANVVQLVPRPEREAAGALVRLPDLVPLVILRGSGESTRALALEAAQHGVRTLAH 262 Query: 269 ELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAK 328 GG V AD D + + C + + + +++Y+EF E Sbjct: 263 ADGGGV-LYVDEKADRDTVRSLVVNSLDRLG--VCNRLNLLLIHDAVYEEFWPVVSEALA 319 Query: 329 KYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFS 388 + + + P Y+ LD A++ Sbjct: 320 ERGV------SPSLPPYDHPIGYEWALDSEREATVTVARV-------------------D 354 Query: 389 NVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQ 448 V + +RIA EE GL+AG+ T+D A Q Sbjct: 355 GVAEAVRIANEET------------------------SGLAAGIATEDARAAEEFFDGYQ 390 Query: 449 AGTVWVNCYGVVSAQCPFGGFKMSGNG 475 V+ N + G +G Sbjct: 391 GTGVFWNAPTRLLDGFKLLGVPETGIN 417 >3AGK-A nrPDB Length = 373 Score = 33.3 bits (75), Expect = 0.26, Method: Composition-based stats. Identities = 14/100 (14%), Positives = 32/100 (32%), Gaps = 21/100 (21%) Query: 317 DEFVRRSVERAKKYILGN-PLTPGVTQGPQID---KEQYDKILDLIESGKKEGAKLECGG 372 +EF + + G + + G E + + + +E K GA++ Sbjct: 287 EEFKLHLAKGTGMIVYGEKDVEAALEMGAVKTLLIHESREDLEEWVEKAKSSGAQVIVVP 346 Query: 373 GPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFK 412 +F++ FG + I++F+ Sbjct: 347 ESLAEAEWFLK-----------------TFGGLAGILRFR 369 >1PDZ-A nrPDB Length = 434 Score = 32.1 bits (72), Expect = 0.61, Method: Composition-based stats. Identities = 23/119 (19%), Positives = 39/119 (32%), Gaps = 11/119 (9%) Query: 210 KEAGFPPGVVNIVPGYGPTAGAAISSHMDI---DKVAFTGSTEVGKLIKEAAGKSNLKRV 266 E P N++ G I +FT + +G + R Sbjct: 141 DEVILPVPAFNVINGGSHAGNKLAMQEFMILPTGATSFTEAMRMGTEVYHHLKAVIKARF 200 Query: 267 TLEL------GGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCI--AASRIFVEESIYD 317 L+ GG +P I+ LD E + + + + AAS + + +IYD Sbjct: 201 GLDATAVGDEGGFAPNILNNKDALDLIQEAIKKAGYTGKIEIGMDVAASEFYKQNNIYD 259 >4U83-A nrPDB Length = 382 Score = 31.3 bits (70), Expect = 0.87, Method: Composition-based stats. Identities = 19/94 (20%), Positives = 33/94 (35%), Gaps = 12/94 (12%) Query: 60 VDKAVKAARQAFQIGSPWRT------MDASERGRLLYKLADLIER----DRLLLATMESM 109 +AV AR AF+ + E + ++LAD+ R +++L Sbjct: 252 AAQAVGMARAAFEAARDYARERITFGKPIIEHQAVAFRLADMATRIETARQMVLHAAALR 311 Query: 110 NGGKL-YSNAYLNDLAGCIKTLRYCAGWADKIQG 142 GK + A + L + A +I G Sbjct: 312 EAGKPCLTEASMAKLV-ASEMAEQVCSAAIQIHG 344 >6AHD-9 nrPDB Length = 800 Score = 31.0 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 19/78 (24%), Positives = 32/78 (41%), Gaps = 14/78 (17%) Query: 43 PATEEELCQVEEGDKEDVDKAVKAARQAFQIGS------------PWRTMDAS--ERGRL 88 P T + + + +E++ + + AA++ + PW A+ ER R Sbjct: 150 PVTADVINPMALRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQ 209 Query: 89 LYKLADLIERDRLLLATM 106 L K DL E+ LL M Sbjct: 210 LQKEKDLAEKRAKLLEEM 227 >4N4Q-A nrPDB Length = 296 Score = 31.0 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 21/83 (25%), Positives = 30/83 (36%), Gaps = 23/83 (27%) Query: 194 PAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVG-- 251 PA TP T + +AG VVN + +D + TGST Sbjct: 12 PAMVTPFTKDG---KLHKAGV-KEVVNF-----------LVEKQKVDGIYITGSTGEFLL 56 Query: 252 ------KLIKEAAGKSNLKRVTL 268 K + + ++N RVTL Sbjct: 57 LSFEDKKEVMKLVAEANAGRVTL 79 >3DOD-A nrPDB Length = 448 Score = 31.0 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 11/30 (36%), Positives = 16/30 (53%), Gaps = 2/30 (6%) Query: 85 RGRLLYKLADLIERDRLLLATM--ESMNGG 112 R + L +LA L+E +A + ESM G Sbjct: 193 RDQCLRELAQLLEEHHEEIAALSIESMVQG 222 >4Q1V-A nrPDB Length = 710 Score = 31.0 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 16/59 (27%), Positives = 21/59 (35%), Gaps = 4/59 (6%) Query: 434 TKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFK---MSGNGRELGEYGFHEYTEV 489 TK + T L++G VN +Q PF K SG G Y Y+ Sbjct: 367 TKRKEVIFTAVEGLRSGHFAVNVSNGKISQ-PFENCKESEHSGTLSASGTYLIDRYSTK 424 >3Q09-A nrPDB Length = 248 Score = 30.6 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 7/31 (22%), Positives = 15/31 (48%) Query: 71 FQIGSPWRTMDASERGRLLYKLADLIERDRL 101 F++ W + +ER ++ LIE+ + Sbjct: 27 FKLRPDWNKVPVAERKGAAEEVKKLIEKHKD 57 >6M99-B nrPDB Length = 728 Score = 30.2 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 17/89 (19%), Positives = 29/89 (32%), Gaps = 10/89 (11%) Query: 9 LPVLLTDLKIQYTKIFINNEWHDSVSGKKFPV--------FNP-ATEEELCQVEEGDKED 59 LP + +DL I I+++ F +P + + + + Sbjct: 421 LPAMFSDLPILEQAAVIDSDALGDSLRPSFETQFLERLENLDPNLLDRAVASILSPTSDT 480 Query: 60 VDKAVKAARQAFQIGSPWRTMDASERGRL 88 D AV AF M ++R RL Sbjct: 481 SDDAVTTVLDAFNALYR-EIMTPAQRARL 508 >5IPN-F nrPDB Length = 336 Score = 30.2 bits (67), Expect = 2.3, Method: Composition-based stats. Identities = 26/131 (19%), Positives = 40/131 (30%), Gaps = 5/131 (3%) Query: 33 VSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKL 92 G V + AT+ L ++ ++ V AR+A + R RL+ K+ Sbjct: 47 SQGATQRVLD-ATQLYLGEIGYSPLLTAEEEVYFARRALRGDVASRRRMIESNLRLVVKI 105 Query: 93 ADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFF 152 A L L + L D + Y W + R I Sbjct: 106 ARRYGNRGLALLDLIEEGNLGLIRAVEKFDPERGFRFSTYATWWIRQTIERAI----MNQ 161 Query: 153 TYTRHEPIGVC 163 T T PI + Sbjct: 162 TRTIRLPIHIV 172 >1R6V-A nrPDB Length = 671 Score = 29.8 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 9/37 (24%), Positives = 15/37 (40%) Query: 449 AGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHE 485 AG +W +G +GG+ S +E +Y Sbjct: 251 AGIIWATDHGAKVMNHSWGGWGYSYTMKEAFDYAMEH 287 >4X6G-A nrPDB Length = 316 Score = 29.8 bits (66), Expect = 2.9, Method: Composition-based stats. Identities = 23/93 (24%), Positives = 39/93 (41%), Gaps = 4/93 (4%) Query: 313 ESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGG 372 + + DE ER+K + P+ G+ Q EQ I +L ++GK + A G Sbjct: 43 KKLEDELGVLIFERSKSAVRLTPVGEGIVAQAQKVLEQAQGIRELAQAGKNQLAAPLKVG 102 Query: 373 GPWGNKGYFVQPTVFS---NVTDEMRIAKEEIF 402 + G ++ P + V +M + EE F Sbjct: 103 AIY-TIGPYLFPHLIPQLHRVAPQMPLYIEENF 134 >1J3N-A nrPDB Length = 408 Score = 29.8 bits (66), Expect = 2.9, Method: Composition-based stats. Identities = 26/105 (24%), Positives = 38/105 (36%), Gaps = 13/105 (12%) Query: 194 PAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPT--AGA---------AISSHMDIDKV 242 P + AL +A +K+AG P V + +G + G H V Sbjct: 270 PHPEGKGAALAMARALKDAGIAPEQVGYINAHGTSTPVGDRAEVLAIKRVFGDHAKRLMV 329 Query: 243 AFTGSTEVGKLIKEAAGKSNLKRV-TLELGGKSPCIVLADADLDN 286 + T S +G L+ A + V L G P I L D D + Sbjct: 330 SSTKSM-IGHLLGAAGAVEAIATVQALYHGVIPPTINLEDPDPEL 373 >4AC0-A nrPDB Length = 202 Score = 29.8 bits (66), Expect = 3.2, Method: Composition-based stats. Identities = 21/88 (23%), Positives = 40/88 (45%), Gaps = 3/88 (3%) Query: 313 ESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGG 372 ES D F+R + + + +L + V G + ++QY+ + + + ++G LE Sbjct: 72 ESWQD-FLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENAL 130 Query: 373 GPWGNKGYFVQPTVFSNVTDEMRIAKEE 400 G+F V + E ++AKEE Sbjct: 131 YALSAVGHFTLGCVLED--QEHQVAKEE 156 >3A2Q-A nrPDB Length = 493 Score = 29.8 bits (66), Expect = 3.2, Method: Composition-based stats. Identities = 13/57 (22%), Positives = 20/57 (35%), Gaps = 8/57 (14%) Query: 91 KLADLIERDRLLLATMESM--------NGGKLYSNAYLNDLAGCIKTLRYCAGWADK 139 +A IER+ L+ + K A C+ LRY AG ++ Sbjct: 319 AIAREIERNGELIGRPLTEDDVEWTSWEMVKRADQVTGRAFAACVDELRYYAGKVER 375 >3LOO-A nrPDB Length = 365 Score = 29.4 bits (65), Expect = 3.3, Method: Composition-based stats. Identities = 14/49 (28%), Positives = 22/49 (44%), Gaps = 8/49 (16%) Query: 399 EEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSAL 447 EEIF P ++ F + + I A YG T+D+ + +AL Sbjct: 226 EEIF-PYVDVL-FGNETEAIALAKEFNYG------TEDLREIGKRIAAL 266 >2CUN-A nrPDB Length = 410 Score = 29.4 bits (65), Expect = 3.6, Method: Composition-based stats. Identities = 17/66 (25%), Positives = 27/66 (40%), Gaps = 5/66 (7%) Query: 343 GPQIDKEQYDKILDLIESGKKEGAKLECG---GGPWGNKGYFVQ--PTVFSNVTDEMRIA 397 G I ++ +L I + GAK+ G G P+ + V S + D+ Sbjct: 27 GKIISDARFKAVLPTIRYLIESGAKVVIGTHQGKPYSEDYTTTEEHARVLSELLDQHVEY 86 Query: 398 KEEIFG 403 E+IFG Sbjct: 87 IEDIFG 92 >1VLC-A nrPDB Length = 366 Score = 29.4 bits (65), Expect = 3.7, Method: Composition-based stats. Identities = 16/75 (21%), Positives = 27/75 (36%), Gaps = 6/75 (8%) Query: 28 EWHDSVSGKKFP-VFNPATEEELCQVEEGDKEDVDKAVKAARQAFQI---GSPWRTMDAS 83 E + +GK F VF + + + E E+ K A F G W + Sbjct: 36 EVVEKKTGKTFEKVFGHIGGDAIDRFGEPLPEETKKICLEADAIFLGSVGGPKWDDLPPE 95 Query: 84 ERGRL--LYKLADLI 96 +R + L L ++ Sbjct: 96 KRPEIGGLLALRKML 110 >3UF0-A nrPDB Length = 273 Score = 29.4 bits (65), Expect = 3.9, Method: Composition-based stats. Identities = 20/79 (25%), Positives = 27/79 (34%), Gaps = 13/79 (16%) Query: 216 PGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLE---LGG 272 G +V G G G AI+ G G + +K V E GG Sbjct: 30 AGRTAVVTGAGSGIGRAIAH----------GYARAGAHVLAWGRTDGVKEVADEIADGGG 79 Query: 273 KSPCIVLADADLDNAVEFA 291 + +V ADL+ A A Sbjct: 80 SAEAVVADLADLEGAANVA 98 >2IPH-A nrPDB Length = 181 Score = 29.0 bits (64), Expect = 5.1, Method: Composition-based stats. Identities = 12/31 (38%), Positives = 18/31 (58%), Gaps = 1/31 (3%) Query: 379 GYFVQPTVFSNVTDEMRIAKEEIFG-PVQQI 408 G++V PTVF T + + +E FG P+ I Sbjct: 17 GFWVSPTVFITTTHVIPTSAKEFFGEPLTSI 47 >1NNE-A nrPDB Length = 765 Score = 29.0 bits (64), Expect = 5.1, Method: Composition-based stats. Identities = 15/56 (26%), Positives = 23/56 (41%), Gaps = 2/56 (3%) Query: 83 SERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWAD 138 E+ R +Y+L LI R +E K + A L + A + L A A+ Sbjct: 482 KEKEREVYRLEALIRRREEE-VFLEVRERAKRQAEA-LREAARILAELDVYAALAE 535 >1EWR-A nrPDB Length = 649 Score = 29.0 bits (64), Expect = 5.3, Method: Composition-based stats. Identities = 15/56 (26%), Positives = 23/56 (41%), Gaps = 2/56 (3%) Query: 83 SERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWAD 138 E+ R +Y+L LI R +E K + A L + A + L A A+ Sbjct: 366 KEKEREVYRLEALIRRREEE-VFLEVRERAKRQAEA-LREAARILAELDVYAALAE 419 >1QNN-A nrPDB Length = 191 Score = 28.6 bits (63), Expect = 5.8, Method: Composition-based stats. Identities = 20/97 (20%), Positives = 33/97 (34%), Gaps = 19/97 (19%) Query: 279 LADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTP 338 +ADL+ V+ + G+F + GQ + ++Y ++ G P Sbjct: 48 FENADLNTIVQKSEGGIFNNAGQT--------LNHNLY----------FTQFRPGKGGAP 89 Query: 339 GVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPW 375 G ID +Q+ E G L G W Sbjct: 90 KGKLGEAID-KQFGSFEKFKEEFNTAGTTLFGSGWVW 125 >2DG6-A nrPDB Length = 222 Score = 28.3 bits (62), Expect = 7.5, Method: Composition-based stats. Identities = 17/106 (16%), Positives = 35/106 (33%), Gaps = 16/106 (15%) Query: 46 EEELCQVEE-GDKEDVDKAVKAARQ---------AFQIGSPWRTMDASERGRLLYKLADL 95 L + + + ++ D AV AAR ++ + R L+ +A L Sbjct: 83 GAALWALPQDAEPDEADPAVAAARVEVDRLLELLGWETSRELAPLSPVHRS-LVVAVAAL 141 Query: 96 IERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141 D A + + Y + + + A A+K++ Sbjct: 142 RRLDYPWDAELMA-----PYGELMMEVARRDLDFMETHASEAEKVE 182 >4WJB-A nrPDB Length = 424 Score = 28.3 bits (62), Expect = 8.0, Method: Composition-based stats. Identities = 18/71 (25%), Positives = 33/71 (46%), Gaps = 1/71 (1%) Query: 204 HVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNL 263 A + AG GV + G T GA + +++++ + G+ VG AA + ++ Sbjct: 145 RFAPAMVSAGVFSGVYTLEYGLSRTDGAGRTIGEELERIGYAGAEPVGGYPVHAAYELHI 204 Query: 264 KR-VTLELGGK 273 ++ LE GK Sbjct: 205 EQGAILERAGK 215 >3WGL-A nrPDB Length = 390 Score = 27.9 bits (61), Expect = 10.0, Method: Composition-based stats. Identities = 17/74 (22%), Positives = 29/74 (39%), Gaps = 3/74 (4%) Query: 323 SVERAKKYILGNPLTPGVTQG--PQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGY 380 + K +G LT G+ G P+I K+ ++ + IE +GA + G Sbjct: 54 LSKAESKIQIGEKLTRGLGAGANPEIGKKAAEESREQIEDAI-QGADMVFVTSGMGGGTG 112 Query: 381 FVQPTVFSNVTDEM 394 V + + EM Sbjct: 113 TGAAPVVAKIAKEM 126 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.313 0.157 0.456 Lambda K H 0.267 0.0480 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 22,434,184 Number of Sequences: 36641 Number of extensions: 1056338 Number of successful extensions: 4532 Number of sequences better than 10.0: 149 Number of HSP's better than 10.0 without gapping: 221 Number of HSP's successfully gapped in prelim test: 47 Number of HSP's that attempted gapping in prelim test: 3371 Number of HSP's gapped (non-prelim): 287 length of query: 501 length of database: 10,336,785 effective HSP length: 101 effective length of query: 400 effective length of database: 6,636,044 effective search space: 2654417600 effective search space used: 2654417600 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 62 (28.3 bits)