BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P00189 (520 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3MZS-A nrPDB 996 0.0 3N9Z-A nrPDB 759 0.0 4ZGX-A nrPDB 327 5e-90 6M7X-A nrPDB 322 3e-88 3K9V-A nrPDB 227 1e-59 6DA2-A nrPDB 105 4e-23 5VEU-A nrPDB 99 4e-21 5YLW-A nrPDB 92 6e-19 6B82-A nrPDB 88 8e-18 4R1Z-A nrPDB 87 2e-17 5VBU-A nrPDB 86 5e-17 2VE3-A nrPDB 77 2e-14 3QZ1-A nrPDB 76 3e-14 4R20-A nrPDB 76 4e-14 2PG7-A nrPDB 75 5e-14 6IQ5-A nrPDB 74 2e-13 6AYB-A nrPDB 72 7e-13 5FSA-A nrPDB 71 1e-12 5UYS-A nrPDB 70 3e-12 5W0C-A nrPDB 69 5e-12 3MDV-A nrPDB 69 5e-12 6C94-A nrPDB 69 5e-12 1N6B-A nrPDB 69 6e-12 3S79-A nrPDB 68 7e-12 4GQS-A nrPDB 68 1e-11 4H1N-A nrPDB 68 1e-11 2HI4-A nrPDB 68 1e-11 3DL9-A nrPDB 67 1e-11 2NNH-A nrPDB 67 2e-11 3E6I-A nrPDB 66 3e-11 3TBG-A nrPDB 65 5e-11 2W0A-A nrPDB 65 7e-11 3R9C-A nrPDB 64 2e-10 6DWN-A nrPDB 63 3e-10 2WX2-A nrPDB 63 3e-10 2X2N-A nrPDB 62 5e-10 5E0E-A nrPDB 62 7e-10 3MGX-A nrPDB 62 8e-10 2WIY-A nrPDB 61 1e-09 3IBD-A nrPDB 61 1e-09 3EL3-A nrPDB 61 1e-09 5E58-A nrPDB 60 2e-09 3L4D-A nrPDB 60 3e-09 4WMZ-A nrPDB 59 6e-09 5JLC-A nrPDB 57 1e-08 6B11-A nrPDB 56 4e-08 3SN5-A nrPDB 55 6e-08 1CPT-A nrPDB 55 7e-08 6F0B-A nrPDB 54 2e-07 4GGV-A nrPDB 54 2e-07 3A1L-A nrPDB 53 3e-07 5FOI-A nrPDB 52 5e-07 4Z5P-A nrPDB 52 6e-07 1UE8-A nrPDB 52 7e-07 5FYF-A nrPDB 51 1e-06 3TKT-A nrPDB 51 1e-06 2RFC-A nrPDB 51 2e-06 6GK6-A nrPDB 50 2e-06 3JUS-A nrPDB 50 2e-06 3NC3-A nrPDB 50 2e-06 4UBS-A nrPDB 50 2e-06 5VWS-A nrPDB 50 2e-06 3ABB-A nrPDB 50 3e-06 6HQG-A nrPDB 50 3e-06 4RM4-A nrPDB 49 4e-06 2WIO-A nrPDB 49 7e-06 1EHE-A nrPDB 49 8e-06 6HQW-A nrPDB 48 8e-06 4YZR-A nrPDB 48 1e-05 5NWS-A nrPDB 48 1e-05 1UED-A nrPDB 47 1e-05 3A50-A nrPDB 47 2e-05 6CR2-A nrPDB 47 2e-05 5LIE-A nrPDB 47 2e-05 3TYW-A nrPDB 47 3e-05 1GWI-A nrPDB 47 3e-05 5XW2-A nrPDB 46 3e-05 5HDI-A nrPDB 46 3e-05 1Z8P-A nrPDB 46 3e-05 6GMF-A nrPDB 46 3e-05 5CJE-A nrPDB 46 3e-05 2VZM-A nrPDB 46 3e-05 1WIY-A nrPDB 46 4e-05 6A7I-A nrPDB 46 5e-05 3OFT-A nrPDB 46 5e-05 2FR7-A nrPDB 46 5e-05 2Y5N-A nrPDB 45 6e-05 5L1U-A nrPDB 45 6e-05 4JBT-A nrPDB 45 7e-05 4DO1-A nrPDB 45 7e-05 6GII-A nrPDB 45 8e-05 5OFQ-A nrPDB 45 8e-05 5Z9I-A nrPDB 45 9e-05 1F4U-A nrPDB 45 1e-04 3EJB-B nrPDB 45 1e-04 1ODO-A nrPDB 44 1e-04 6G71-A nrPDB 44 1e-04 2ZBZ-A nrPDB 44 1e-04 3ABA-A nrPDB 44 2e-04 3P3Z-A nrPDB 44 2e-04 3WVS-A nrPDB 44 2e-04 4OQS-A nrPDB 44 2e-04 4OQR-A nrPDB 44 2e-04 5H1Z-A nrPDB 44 2e-04 6A7J-A nrPDB 42 5e-04 5IT1-A nrPDB 42 5e-04 5EX6-C nrPDB 42 6e-04 5DE9-A nrPDB 42 6e-04 2RCM-A nrPDB 42 7e-04 5HIW-A nrPDB 42 7e-04 4WPZ-A nrPDB 42 8e-04 3RWL-A nrPDB 42 8e-04 2NZA-A nrPDB 42 0.001 5L94-A nrPDB 41 0.001 5Y1I-A nrPDB 41 0.002 5EX8-A nrPDB 40 0.002 4TRI-A nrPDB 40 0.003 2XKR-A nrPDB 40 0.003 5GWE-A nrPDB 40 0.004 5XJN-A nrPDB 40 0.004 6DCD-A nrPDB 39 0.004 5YSW-A nrPDB 39 0.005 5YHJ-A nrPDB 39 0.007 3DBM-A nrPDB 39 0.008 5HH3-A nrPDB 39 0.008 5D3U-A nrPDB 38 0.012 2ZQJ-A nrPDB 37 0.017 4YT3-A nrPDB 37 0.017 1LG9-A nrPDB 37 0.017 2Z36-A nrPDB 37 0.028 3AWQ-A nrPDB 37 0.029 3BUJ-A nrPDB 36 0.042 4MM0-A nrPDB 35 0.056 6HQD-A nrPDB 35 0.089 4PWV-A nrPDB 35 0.093 6FYJ-A nrPDB 35 0.099 4XE3-A nrPDB 35 0.12 5M0P-A nrPDB 34 0.14 2YJN-B nrPDB 34 0.14 3OO3-A nrPDB 33 0.29 2X9P-A nrPDB 33 0.29 6M7L-A nrPDB 32 0.60 6G5O-A nrPDB 32 0.60 5XNT-A nrPDB 32 0.88 4C9K-A nrPDB 30 1.9 6FSH-A nrPDB 30 1.9 4TX3-A nrPDB 30 2.3 4GPS-A nrPDB 30 2.5 3KBH-E nrPDB 30 2.8 5IPN-F nrPDB 29 5.8 4FF5-A nrPDB 28 9.3 >3MZS-A nrPDB Length = 486 Score = 996 bits (2575), Expect = 0.0, Method: Compositional matrix adjust. Identities = 480/480 (100%), Positives = 480/480 (100%) Query: 41 STKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVY 100 STKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVY Sbjct: 3 STKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVY 62 Query: 101 IIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMA 160 IIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMA Sbjct: 63 IIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMA 122 Query: 161 PEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLG 220 PEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLG Sbjct: 123 PEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLG 182 Query: 221 MLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKY 280 MLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKY Sbjct: 183 MLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKY 242 Query: 281 TEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYE 340 TEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYE Sbjct: 243 TEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYE 302 Query: 341 MARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESD 400 MARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESD Sbjct: 303 MARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESD 362 Query: 401 LVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQ 460 LVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQ Sbjct: 363 LVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQ 422 Query: 461 CVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQDPPQA 520 CVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQDPPQA Sbjct: 423 CVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQDPPQA 482 >3N9Z-A nrPDB Length = 487 Score = 759 bits (1960), Expect = 0.0, Method: Compositional matrix adjust. Identities = 353/480 (73%), Positives = 418/480 (87%), Gaps = 1/480 (0%) Query: 41 STKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVY 100 ST++PRP++EIPSPGDNGWLNLYHFWRE G+ ++H H++NFQKYGPIYREKLGN+ESVY Sbjct: 1 STRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVY 60 Query: 101 IIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMA 160 +I PEDVA LFK EG PER+ IPPW+AYH+YYQ+PIGVL KKS WKKDRV LN EVMA Sbjct: 61 VIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMA 120 Query: 161 PEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLG 220 PEA KNF+PLL+ VS+DFVS+LH+RIK+ GSG + GDI +DLF FAFESITNV+FGER G Sbjct: 121 PEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQG 180 Query: 221 MLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKY 280 MLEE VNPEAQ+FIDA+Y+MFHTSVP+LN+PP+L+RLFRTKTW+DHVAAWD IF+KA+ Y Sbjct: 181 MLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIY 240 Query: 281 TEIFYQDLRRKTEF-RNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLY 339 T+ FY +LR+K +Y GILY LL KM ED+KAN+TEMLAGGV+TTSMTLQWHLY Sbjct: 241 TQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLY 300 Query: 340 EMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPES 399 EMAR+L VQ+MLR EVL AR QA+GD++ MLQ+VPLLKASIKETLRLHPISVTLQRY + Sbjct: 301 EMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVN 360 Query: 400 DLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVR 459 DLVL+DY+IPAKTLVQVAIYA+GR+P FF P+ FDPTRWLSKDK++ +FRNLGFGWGVR Sbjct: 361 DLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVR 420 Query: 460 QCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQDPPQ 519 QC+GRRIAELEMT+FLI++LENF+VE+QH+ DV T FNLIL P+KPI F PFNQ+ Q Sbjct: 421 QCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQ 480 >4ZGX-A nrPDB Length = 489 Score = 327 bits (839), Expect = 5e-90, Method: Compositional matrix adjust. Identities = 177/477 (37%), Positives = 282/477 (59%), Gaps = 1/477 (0%) Query: 38 AGISTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLE 97 A + +T P+ +P N WL L WRE+G + +H + FQ+ GPI+R LG Sbjct: 5 AARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPR 64 Query: 98 SVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTE 157 V ++ PEDV L + + +P R + PW+AY ++ GV W+ +R+ LN + Sbjct: 65 MVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPD 124 Query: 158 VMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGE 217 V++P+A++ F+P+++ V++DF L K++ Q G D++ +FH+ E+ +FGE Sbjct: 125 VLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 184 Query: 218 RLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKA 277 RLG++ + + + F+ A+ MF ++V L+ +P L R K W++H AWD IF Sbjct: 185 RLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYG 244 Query: 278 EKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWH 337 + + YQ+L ++Y GI+ LL ++ LE +KAN E+ AG V+TT+ L Sbjct: 245 DNCIQKIYQELAFNRP-QHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMT 303 Query: 338 LYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYP 397 L+E+AR+ +VQ++LR+E L A K +PLL+A++KETLRL+P+ + L+R Sbjct: 304 LFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVV 363 Query: 398 ESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWG 457 SDLVLQ+Y IPA TLVQV +Y++GR+ A F P++++P RWL +F ++ FG+G Sbjct: 364 SSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFG 423 Query: 458 VRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFN 514 +RQC+GRR+AE EM L L H+L++F VE D+ +++ IL P L FR N Sbjct: 424 MRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN 480 >6M7X-A nrPDB Length = 484 Score = 322 bits (825), Expect = 3e-88, Method: Compositional matrix adjust. Identities = 176/481 (36%), Positives = 280/481 (58%), Gaps = 4/481 (0%) Query: 38 AGISTKTPR---PYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLG 94 A ++ PR P+ +P N WL L WRE+G + +H + FQ+ GPI+R LG Sbjct: 2 AKKTSSVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLG 61 Query: 95 NLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVL 154 V ++ PEDV L + + +P R + PW+AY ++ GV W+ +R+ L Sbjct: 62 GAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRL 121 Query: 155 NTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVM 214 N EV++P A++ F+P+++ V++DF L K++ Q G D++ +FH+ E+ + Sbjct: 122 NPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL 181 Query: 215 FGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIF 274 FGERLG++ + + + F+ A+ MF ++V L+ +P L R K W++H AWD IF Sbjct: 182 FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIF 241 Query: 275 NKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTL 334 + + YQ+L + + Y I+ LL + ++ + +KAN E+ AG V+TT L Sbjct: 242 QYGDNCIQKIYQELA-FSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPL 300 Query: 335 QWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQ 394 L+E+AR+ NVQ+ LR+E L A K +PLL+A++KETLRL+P+ + L+ Sbjct: 301 LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 360 Query: 395 RYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGF 454 R SDLVLQ+Y IPA TLV+V +Y++GR+PA F P++++P RWL +F ++ F Sbjct: 361 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 420 Query: 455 GWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFN 514 G+G+RQC+GRR+AE EM L L H+L++ +VE D+ +++ IL P L FR N Sbjct: 421 GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 480 Query: 515 Q 515 Sbjct: 481 H 481 >3K9V-A nrPDB Length = 482 Score = 227 bits (578), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 143/479 (29%), Positives = 243/479 (50%), Gaps = 30/479 (6%) Query: 46 RPYSEIPSPGDNGWLN--LYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIH 103 R +++P P + L L FW+ G ++ H E +KYG I+R KLG+ +SV++ Sbjct: 21 RNVTDLPGPTNWPLLGSLLEIFWK-GGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGS 79 Query: 104 PEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEA 163 P + L++ E ++P+R +I PW AY + + G++ + W++ R ++M P Sbjct: 80 PSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVE 139 Query: 164 IKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLE 223 I +N V DF+ + + ++G + D+ +L ++FESI V++ +R G+L+ Sbjct: 140 IMKLDKKINEVLADFLERMDELCDERGR---IPDLYSELNKWSFESICLVLYEKRFGLLQ 196 Query: 224 ETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEI 283 + EA FI A+ M T ++ P EL++ TK W+ H AWDTIF + + Sbjct: 197 KETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCID- 255 Query: 284 FYQDLRRKTEFRNYPG--ILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEM 341 R + PG L + + + + +++ A +TE+ V TT+ +L W LY + Sbjct: 256 -----NRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNL 310 Query: 342 ARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDL 401 +R+ Q L +EV + + ++ L+ +P LKA +KE++RL P R + Sbjct: 311 SRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPT 370 Query: 402 VLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQC 461 VL +Y +P T++ + +G F KF P RWL K+K + F +L FG G R C Sbjct: 371 VLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMC 430 Query: 462 VGRRIAELEMTLFLIHILENFK--------VEMQHIGDVDTIFNLILTPDKPIFLVFRP 512 +GRR+AEL++ L L I++ + VEM H+G IL P + + + FRP Sbjct: 431 IGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLG--------ILVPSRELPIAFRP 481 >6DA2-A nrPDB Length = 487 Score = 105 bits (262), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 133/512 (25%), Positives = 222/512 (43%), Gaps = 75/512 (14%) Query: 27 WGHHRVGTGEGAGISTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYG 86 +G H G + GI TP P+ G + YH KG +E +KYG Sbjct: 5 YGTHSHGLFKKLGIPGPTPLPFL--------GNILSYH----KG---FCMFDMECHKKYG 49 Query: 87 PIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGT 146 ++ G + I P+ + + E Y + +R P+G F KS Sbjct: 50 KVWGFYDGQQPVLAITDPDMIKTVL-----VKECYSV----FTNRRPFGPVG--FMKSAI 98 Query: 147 -------WKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIK 199 WK+ R +L+ + + +K +P+ ++Q L+ ++ +GK V +K Sbjct: 99 SIAEDEEWKRLRSLLSPTFTSGK-LKEMVPI---IAQYGDVLVRNLRREAETGKPV-TLK 153 Query: 200 EDLFHFAFESITNVMFGERLGMLEETVNPEAQK--------FIDAVY---KMFHTSVPLL 248 + ++ + IT+ FG + L +P + F+D + +F +P+L Sbjct: 154 DVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPIL 213 Query: 249 NV------PPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILY 302 V P E+ R R ++ +K+ F Q + + Sbjct: 214 EVLNICVFPREVTNFLRKSVKR----MKESRLEDTQKHRVDFLQLMIDSQNSKE------ 263 Query: 303 CLLKSEKML--LEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNAR- 359 +S K L LE V +I + AG TTS L + +YE+A +VQ+ L+EE+ Sbjct: 264 --TESHKALSDLELVAQSIIFIFAG-YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP 320 Query: 360 RQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIY 419 +A +LQM L + ETLRL PI++ L+R + D+ + IP +V + Y Sbjct: 321 NKAPPTYDTVLQM-EYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSY 379 Query: 420 AMGRDPAFFSSPDKFDPTRWLSKDKDLIH-FRNLGFGWGVRQCVGRRIAELEMTLFLIHI 478 A+ RDP +++ P+KF P R+ K+KD I + FG G R C+G R A + M L LI + Sbjct: 380 ALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRV 439 Query: 479 LENFKVEMQHIGDVDTIFNL--ILTPDKPIFL 508 L+NF + + +L +L P+KP+ L Sbjct: 440 LQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 471 >5VEU-A nrPDB Length = 480 Score = 99.0 bits (245), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 63/189 (33%), Positives = 100/189 (52%), Gaps = 8/189 (4%) Query: 325 GGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNAR-RQAEGDISKMLQMVPLLKASIKET 383 G TTS L + LYE+A +VQ+ L++E+ +A ++QM L + ET Sbjct: 284 AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQM-EYLDMVVNET 342 Query: 384 LRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKD 443 LRL P+++ L+R + D+ + IP ++V + YA+ DP +++ P++F P R+ K Sbjct: 343 LRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKK 402 Query: 444 KDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKV----EMQHIGDVDTIFNLI 499 + + FG G R C+G R A + M L LI +L+NF E Q +DT + Sbjct: 403 DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDT--QGL 460 Query: 500 LTPDKPIFL 508 L P+KPI L Sbjct: 461 LQPEKPIVL 469 >5YLW-A nrPDB Length = 495 Score = 91.7 bits (226), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 94/412 (22%), Positives = 175/412 (42%), Gaps = 22/412 (5%) Query: 83 QKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFK 142 ++YGP+ LG+L +V + PE + G I + + + +G L Sbjct: 57 KRYGPLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDKISMGFL-P 115 Query: 143 KSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDL 202 + W+ R + ++ + ++++ L Q LL K SG+ V DI+E Sbjct: 116 VASEWRDMRKICKEQMFSNQSMEASQGLRR---QKLQQLLDHVQKCSDSGRAV-DIREAA 171 Query: 203 FHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKT 262 F ++ +F + + E ++ I+ V + VP + R F + Sbjct: 172 FITTLNLMSATLFSSQATEFDSKATMEFKEIIEGVATI--VGVPNFADYFPILRPFDPQG 229 Query: 263 WRDHVAAWDTIFNKAEKYTEIFYQD-LRRKTEFRNYPG------ILYCLLKSEKMLLEDV 315 + D F K E + + L K N P I+ ++++ + L+ Sbjct: 230 VKRRA---DVFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQANEFKLKTH 286 Query: 316 KAN--ITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMV 373 + ++ GG +T + +++W + E+ + + L+ E+ + + + + Sbjct: 287 HFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDESAMPKL 346 Query: 374 PLLKASIKETLRLHPIS-VTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPD 432 P L+A IKE +R+HP + L R ESD + YLIP T + + YA+GRDP+ ++ P+ Sbjct: 347 PYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSIWTDPE 406 Query: 433 KFDPTRWLSKDKDLI--HFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 FDP R+L D + L FG G R C G +A + + ++ NF Sbjct: 407 TFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNF 458 >6B82-A nrPDB Length = 509 Score = 88.2 bits (217), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 60/202 (29%), Positives = 108/202 (53%), Gaps = 8/202 (3%) Query: 311 LLED-VKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKM 369 L ED V + E+ GV TT+ TL+W + + + VQ ++EE+ + + Sbjct: 282 LTEDHVLMTVGEIFGAGVETTTTTLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSD 341 Query: 370 LQMVPLLKASIKETLRLHPIS-VTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFF 428 +P L+A+I E +R+ P+S + + D + +Y + T V + ++++ D + Sbjct: 342 RGNLPYLEATICEVMRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEW 401 Query: 429 SSPDKFDPTRWLSKDKDLIHFRN---LGFGWGVRQCVGRRIAELEMTLFLIHILENFKVE 485 +P+ FDP R+L+++ D + + L FG GVR C+G +A++E+ LFL IL+ F +E Sbjct: 402 KNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLE 461 Query: 486 M---QHIGDVDTIFNLILTPDK 504 M Q + D+ F ++L P K Sbjct: 462 MPTGQPLPDLQGKFGVVLQPKK 483 >4R1Z-A nrPDB Length = 439 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 59/202 (29%), Positives = 108/202 (53%), Gaps = 8/202 (3%) Query: 311 LLED-VKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKM 369 L ED V + ++ GV TT+ L+W + + + VQ ++EE+ + + Sbjct: 218 LTEDHVLMTVGDIFGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSD 277 Query: 370 LQMVPLLKASIKETLRLHPIS-VTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFF 428 +P L+A+I+E LR+ P+S + + D + +Y + T V + ++++ D + Sbjct: 278 RGNLPYLEATIREVLRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEW 337 Query: 429 SSPDKFDPTRWLSKDKDLIHFRN---LGFGWGVRQCVGRRIAELEMTLFLIHILENFKVE 485 +P+ FDP R+L+++ D + + L FG GVR C+G +A++E+ LFL IL+ F +E Sbjct: 338 KNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLE 397 Query: 486 M---QHIGDVDTIFNLILTPDK 504 M Q + D+ F ++L P K Sbjct: 398 MPTGQPLPDLQGKFGVVLQPKK 419 >5VBU-A nrPDB Length = 476 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 108/454 (23%), Positives = 196/454 (43%), Gaps = 51/454 (11%) Query: 83 QKYGPIYREKLGNLESVYIIHPEDVAH--LFKFEGSYPERYDIPPWLAYHRYYQKPIGVL 140 QK+GPIYR LG L+ V +++ + + K + R + + R Y P L Sbjct: 35 QKFGPIYRLHLG-LQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNY--PDLSL 91 Query: 141 FKKSGTWKKDRVVLNTEVMAPEAIKNFI-PLLNPVSQDFVSLLHKRIKQQGSGKFVGDIK 199 S WK + + + ++ I++ + P++ ++Q+F +R++ Q I+ Sbjct: 92 GDYSLLWKAHKKLTRSALLL--GIRDSMEPVVEQLTQEFC----ERMRAQPGTPVA--IE 143 Query: 200 EDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMF-HTSVPLLNV-------- 250 E+ I + FG+++ ++ + P K I V K + H S+ +++V Sbjct: 144 EEFSLLTCSIICYLTFGDKIK--DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFP 201 Query: 251 PPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLK--SE 308 P L RL + RDH+ + + ++ E R G+ ++ S Sbjct: 202 NPGLRRLKQAIEKRDHI-----VEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSG 256 Query: 309 KMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEV-------LNARRQ 361 ++L V ++L GG TT+ TL W + + +Q+ L+EE+ ++ R Sbjct: 257 QLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRV 316 Query: 362 AEGDISKMLQMVPLLKASIKETLRLHPI-SVTLQRYPESDLVLQDYLIPAKTLVQVAIYA 420 D +++ PLL A+I E LRL P+ + L + Y IP T++ + Sbjct: 317 PYKDRARL----PLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQG 372 Query: 421 MGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILE 480 D + P +F P R+L K+ R L FG G R C+G +A LE+ + L +L+ Sbjct: 373 AHLDETVWERPHEFWPDRFLEPGKN---SRALAFGCGARVCLGEPLARLELFVVLTRLLQ 429 Query: 481 NFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFN 514 F + + D + +L P + L +PF Sbjct: 430 AFTL----LPSGDALPSLQPLPHCSVILKMQPFQ 459 >2VE3-A nrPDB Length = 444 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 89/414 (21%), Positives = 168/414 (40%), Gaps = 56/414 (13%) Query: 83 QKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFK 142 Q++GPI++ +L ++I LF E + W R P L Sbjct: 41 QQFGPIFKTRLFGKNVIFISGALANRFLFTKEQETFQAT----WPLSTRILLGP-NALAT 95 Query: 143 KSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDL 202 + G + R + + P + +++P ++ + Q + ++Q G V + L Sbjct: 96 QMGEIHRSRRKILYQAFLPRTLDSYLPKMDGIVQGY-------LEQWGKANEVIWYPQ-L 147 Query: 203 FHFAFESITNVMFGERLGMLEETVNPEAQKFIDA-VYKMFHTSVPLLNVPPELYRLFRTK 261 F+ + GE++ + NP+ + + + +F +PL N Sbjct: 148 RRMTFDVAATLFMGEKV-----SQNPQLFPWFETYIQGLFSLPIPLPN------------ 190 Query: 262 TWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYP--------GILYCLL--KSEKML 311 T+F K+++ + +L + + R GIL ++ + Sbjct: 191 ----------TLFGKSQRARALLLAELEKIIKARQQQPPSEEDALGILLAARDDNNQPLS 240 Query: 312 LEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQ 371 L ++K I +L G T + L + + +++E +R+E N + ++ ++ L+ Sbjct: 241 LPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQ-NKLQLSQELTAETLK 299 Query: 372 MVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSP 431 +P L ++E LRL P R D Q + P LV I DP + P Sbjct: 300 KMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQGFHFPKGWLVSYQISQTHADPDLYPDP 359 Query: 432 DKFDPTRWLSKDKDLIH---FRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 +KFDP R+ + D H F ++ FG G+R+C+G+ A LEM LF +++ F Sbjct: 360 EKFDPERF-TPDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKLFATRLIQQF 412 >3QZ1-A nrPDB Length = 496 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 101/441 (22%), Positives = 177/441 (40%), Gaps = 61/441 (13%) Query: 83 QKYGPIYREKLGNLESVYIIHPEDVAH-LFKFEGSYPERYDIPPW-LAYHRYYQKPIG-- 138 QK GP+YR +LG E V + + + + + R IP + L R +G Sbjct: 54 QKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAGRPQIPSYKLVSQRCQDISLGDY 113 Query: 139 -VLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGD 197 +L+K + ++L T + P ++ ++Q+F +R++ Q Sbjct: 114 SLLWKAHKKLTRSALLLGTR-------SSMEPWVDQLTQEFC----ERMRVQAGAPVT-- 160 Query: 198 IKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMF----HTSVPLLN-VP- 251 I+++ I + FG + E+T+ F D V + H S+ +L+ VP Sbjct: 161 IQKEFSLLTCSIICYLTFGNK----EDTL---VHAFHDCVQDLMKTWDHWSIQILDMVPF 213 Query: 252 ------PELYRLFRTKTWRDHVA-------AWDTIFNKAEKYTEIFYQDLRRKTEFRNYP 298 P L+RL + RDH+ + + T+ Q + R+ P Sbjct: 214 LRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDYMLQGVGRQ-RVEEGP 272 Query: 299 GILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEV--- 355 G ++L V ++ ++ GG TT+ TL W + + +Q L+EE+ Sbjct: 273 G---------QLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELDRE 323 Query: 356 LNARRQAEGDISKMLQMVPLLKASIKETLRLHPI-SVTLQRYPESDLVLQDYLIPAKTLV 414 L K +PLL A+I E LRL P+ + L + Y IP +V Sbjct: 324 LGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMVV 383 Query: 415 QVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLF 474 + D + P +F P R+L + L FG G R C+G +A LE+ + Sbjct: 384 IPNLQGAHLDETVWEQPHEFRPDRFLEPGANP---SALAFGCGARVCLGESLARLELFVV 440 Query: 475 LIHILENFKVEMQHIGDVDTI 495 L +L+ F + +G + ++ Sbjct: 441 LARLLQAFTLLPPPVGALPSL 461 >4R20-A nrPDB Length = 486 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 54/197 (27%), Positives = 89/197 (45%), Gaps = 5/197 (2%) Query: 313 EDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQM 372 + V E GV TTS TL W + + +QE ++ E+ Sbjct: 275 DHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPH 334 Query: 373 VPLLKASIKETLRLHPIS-VTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSP 431 +PLL A + E +R+ P+S + + D L + +P T V V ++A+ DP + P Sbjct: 335 LPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQP 394 Query: 432 DKFDPTRWLS-KDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEM---Q 487 ++F+P R+L K L FG G R CVG +A +E+ LF+ L+ F Sbjct: 395 EQFNPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFSCPSEA 454 Query: 488 HIGDVDTIFNLILTPDK 504 + D+ F ++L P++ Sbjct: 455 SLPDLQGRFGVVLQPER 471 >2PG7-A nrPDB Length = 476 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 55/193 (28%), Positives = 96/193 (49%), Gaps = 19/193 (9%) Query: 312 LEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREE---VLNARRQAE-GDIS 367 L+++ ++ GG T S TL++ + + V+ + EE V+ RQ + D + Sbjct: 266 LKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRA 325 Query: 368 KMLQMVPLLKASIKETLRLHP-ISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPA 426 KM P ++A I E R I ++L R + D +D+ +P T V + ++ RDP+ Sbjct: 326 KM----PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPS 381 Query: 427 FFSSPDKFDPTRWLS-----KDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILEN 481 FFS+P F+P +L+ K D + F G R C G +A +E+ LF +++N Sbjct: 382 FFSNPQDFNPQHFLNEKGQFKKSDAF----VPFSIGKRNCFGEGLARMELFLFFTTVMQN 437 Query: 482 FKVE-MQHIGDVD 493 F+++ Q D+D Sbjct: 438 FRLKSSQSPKDID 450 >6IQ5-A nrPDB Length = 463 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 53/176 (30%), Positives = 89/176 (50%), Gaps = 14/176 (7%) Query: 309 KMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREE----VLNARRQAEG 364 ++ LE+V A IT++ +T S LQW L R +VQ ++ E V R G Sbjct: 247 RLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMG 306 Query: 365 DISKMLQMVPLLKASIKETLRLHP-ISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGR 423 D + P + A + E +R + VT+ ++ + Y IP T+V V +++ Sbjct: 307 DQPNL----PYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNH 362 Query: 424 DPAFFSSPDKFDPTRWLSKD----KDLIHFRNLGFGWGVRQCVGRRIAELEMTLFL 475 DP + +P+ FDP R+L KD KDL R + F G R+C+G ++++++ LF+ Sbjct: 363 DPVKWPNPENFDPARFLDKDGLINKDLTS-RVMIFSVGKRRCIGEELSKMQLFLFI 417 >6AYB-A nrPDB Length = 466 Score = 71.6 bits (174), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 51/195 (26%), Positives = 100/195 (51%), Gaps = 11/195 (5%) Query: 323 LAGGVNTTSMTLQWHLYEMARSLNVQEMLR---EEVLNARRQAEGDISKMLQMVPLLKAS 379 L G +T+S+T W L + + V E +R EE++ + + + D K+++M L+A Sbjct: 266 LFAGQHTSSITSSWTLMNVISNKKVLEKVRKEQEEIMGSDKVLDYD--KVMKM-DYLEAC 322 Query: 380 IKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRW 439 +KE LR++P + + R + Y+IP ++ V+ GR +++PD FDP R Sbjct: 323 MKEALRMYPPLIMIMRMARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERL 382 Query: 440 LS-KDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDV--DTIF 496 K+ + + + FG G +C+G A L++ + +L F +M++IG + + Sbjct: 383 TERKEHEKFKYGAVPFGAGRHKCIGENFALLQVKSIISILLRYF--DMEYIGKIPDPSYT 440 Query: 497 NLILTPDKPIFLVFR 511 +L++ P P + ++ Sbjct: 441 SLVVGPSPPTRMRYK 455 >5FSA-A nrPDB Length = 490 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 54/236 (22%), Positives = 112/236 (47%), Gaps = 40/236 (16%) Query: 309 KMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISK 368 KM +++ + +L GG +T++ T W L + ++Q+++ +EV+ ++ GD++ Sbjct: 249 KMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLND 308 Query: 369 M----LQMVPLLKASIKETLRLH-PISVTLQ------RYPESDLVLQDYLIPAKTLVQVA 417 + LQ +P + +IKETLR+H P+ + R PE+ +Y++P V V+ Sbjct: 309 LTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPET-----NYIVPKGHYVLVS 363 Query: 418 IYAMGRDPAFFSSPDKFDPTRW--LSKDKDLIHFRN-------------------LGFGW 456 +F +P+ FDPTRW + + + F + L FG Sbjct: 364 PGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGG 423 Query: 457 GVRQCVGRRIAELEMTLFLIHILENFK--VEMQHIGDVDTIFNLILTPDKPIFLVF 510 G +C+G + A +++ L + N + ++ + D D ++++ P +P +++ Sbjct: 424 GRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPD-YSSMVVLPTEPAEIIW 478 >5UYS-A nrPDB Length = 494 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 100/446 (22%), Positives = 190/446 (42%), Gaps = 60/446 (13%) Query: 83 QKYGPIYREKLGNLESVYIIHPEDVAHLFKFEG-SYPERYDIPPWLAYHRYYQKPIGVLF 141 +KYGPIY ++G +V + H + + +G + R P G+ F Sbjct: 40 KKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGR---PQMATLDIASNNRKGIAF 96 Query: 142 KKSGT-WK-KDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIK 199 SG W+ R+ + T + + + + + Q+ +L G Sbjct: 97 ADSGAHWQLHRRLAMATFALFKDGDQKLEKI---ICQEISTLCDMLATHNGQSI------ 147 Query: 200 EDLFHFAFESITNVMFGERLGMLEETVNPE---AQKFIDAVYKMFHTSVPLLNVPPELYR 256 D+ F ++TNV+ + +PE Q + + + + L+++ P L + Sbjct: 148 -DISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNL-SKDSLVDLVPWL-K 204 Query: 257 LFRTKTW---RDHVAAWDTIFNKA-EKYTEIFYQDLRRKTEFRNYPGILYCLLKS----- 307 +F KT + HV + + NK E Y E F D + +L L+++ Sbjct: 205 IFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSD--------SITNMLDTLMQAKMNSD 256 Query: 308 --------EKMLLED--VKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLN 357 + LL D + I ++ GV TT+ ++W L + + V++ L EE+ Sbjct: 257 NGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQ 316 Query: 358 ----ARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPES-DLVLQDYLIPAKT 412 +R D +++L LL+A+I+E LRL P++ L + + D + ++ + T Sbjct: 317 NVGFSRTPTISDRNRLL----LLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGT 372 Query: 413 LVQVAIYAMGRDPAFFSSPDKFDPTRWLS-KDKDLI--HFRNLGFGWGVRQCVGRRIAEL 469 V + ++A+ + + PD+F P R+L+ LI L FG G R C+G +A Sbjct: 373 EVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQ 432 Query: 470 EMTLFLIHILENFKVEMQHIGDVDTI 495 E+ L + +L+ F +E+ G + ++ Sbjct: 433 ELFLIMAWLLQRFDLEVPDDGQLPSL 458 >5W0C-A nrPDB Length = 477 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 51/224 (22%), Positives = 101/224 (45%), Gaps = 15/224 (6%) Query: 264 RDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEML 323 ++H + D N + + + F + + E N P + +E ++ ++ Sbjct: 232 KEHQESMD--MNNPQDFIDCFLMKMEK--EKHNQPS---------EFTIESLENTAVDLF 278 Query: 324 AGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKET 383 G TTS TL++ L + + V ++EE+ + + +P A + E Sbjct: 279 GAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEV 338 Query: 384 LR-LHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSK 442 R + + +L D+ ++YLIP T + +++ ++ D F +P+ FDP +L + Sbjct: 339 QRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDE 398 Query: 443 DKDLIHFRN-LGFGWGVRQCVGRRIAELEMTLFLIHILENFKVE 485 + + + F G R CVG +A +E+ LFL IL+NF ++ Sbjct: 399 GGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLK 442 >3MDV-A nrPDB Length = 456 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 96/442 (21%), Positives = 182/442 (41%), Gaps = 34/442 (7%) Query: 83 QKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPI---GV 139 +KYGP+ R + + SV + PE V KF S D + A + + + G+ Sbjct: 21 KKYGPVVRVNVFHKTSVIVTSPESVK---KFLMSTKYNKDSKMYRALQTVFGERLFGQGL 77 Query: 140 LFKKS-GTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDI 198 + + + W K R V++ + ++ + + N ++ V +L + G+ + Sbjct: 78 VSECNYERWHKQRRVIDL-AFSRSSLVSLMETFNEKAEQLVEILEAK----ADGQTPVSM 132 Query: 199 KEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLF 258 ++ L + A + + FG ML P +Q AV M N + Sbjct: 133 QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQ----AVKLMLEGITASRNTLAKFLPGK 188 Query: 259 RTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLED--VK 316 R K R+ + + + + + L+R E IL +LK+E+ +D + Sbjct: 189 R-KQLREVRESIRFLRQVGRDWVQRRREALKRGEEVP--ADILTQILKAEEGAQDDEGLL 245 Query: 317 ANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLR---EEVLNARRQAEGDISKMLQMV 373 N G T++ L + + E++R + L+ +EV+ ++R + + LQ Sbjct: 246 DNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQY- 304 Query: 374 PLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDK 433 L +KE+LRL+P + R E + ++ +P T + + Y MGR +F P Sbjct: 305 --LSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLT 362 Query: 434 FDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEM---QHIG 490 F+P R+ F F G R C+G++ A++E+ + + +L+ + + Q G Sbjct: 363 FNPDRF-GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFG 421 Query: 491 DVDTIFNLILTPDKPIFLVFRP 512 + L P P+ RP Sbjct: 422 LQE---QATLKPLDPVLCTLRP 440 >6C94-A nrPDB Length = 497 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 92/207 (44%), Gaps = 10/207 (4%) Query: 314 DVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKM---- 369 D++A + + G +TT+ + W LY MA Q+ REEV R+ GD Sbjct: 282 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQRCREEV----REILGDQDSFQWED 337 Query: 370 LQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQD-YLIPAKTLVQVAIYAMGRDPAFF 428 L + L +KE RL+P + R + D +PA +L+ + IYA+ R+ + Sbjct: 338 LAKMTYLTMCMKECFRLYPPVPQVYRQLSKPVSFVDGRSLPAGSLISLHIYALHRNSDVW 397 Query: 429 SSPDKFDPTRWLSKDKDLIH-FRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQ 487 P+ FDP R+ ++ H + + F G R C+G++ A EM + L F+ + Sbjct: 398 PDPEVFDPLRFSPENSSGRHPYAFIPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSVD 457 Query: 488 HIGDVDTIFNLILTPDKPIFLVFRPFN 514 + + L+L I L +P Sbjct: 458 PLRLPIKLPQLVLRSKNGIHLYLKPLG 484 >1N6B-A nrPDB Length = 473 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 97/424 (22%), Positives = 169/424 (39%), Gaps = 47/424 (11%) Query: 83 QKYGPIYREKLGNLESVYIIHPEDVAH-LFKFEGSYPERYDIPPWLAYHRYYQKPIGVLF 141 + YGP++ LG +V + E V L + R +P K +G+ F Sbjct: 41 ECYGPVFTVYLGMKPTVVLHGYEAVKEALVDLGEEFAGRGSVPIL----EKVSKGLGIAF 96 Query: 142 KKSGTWKKDR----VVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGD 197 + TWK+ R + L M +I++ I ++ V L K F+ Sbjct: 97 SNAKTWKEMRRFSLMTLRNFGMGKRSIEDRI---QEEARCLVEELRKTNASPCDPTFI-- 151 Query: 198 IKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVP-PELYR 256 L I +V+F R +E E K ++++ H +V LL P ++Y Sbjct: 152 ----LGCAPCNVICSVIFHNRFDYKDE----EFLKLMESL----HENVELLGTPWLQVYN 199 Query: 257 LFRTKTWRDHVAAWDTIFNKAEKYTEIF-------YQDLRRKTEFRNYPGILYCLLKSEK 309 F D+ K Y + F +Q L R++ ++ E Sbjct: 200 NF--PALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDVNNPRDFIDCFLIKMEQEN 257 Query: 310 ML---LEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDI 366 L LE + ++++ G TTS TL++ L + + V ++EE+ + Sbjct: 258 NLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPEVAARVQEEIERVIGRHRSPC 317 Query: 367 SKMLQMVPLLKASIKETLR-LHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDP 425 + +P A I E R + + L D+ ++Y IP T + ++ ++ D Sbjct: 318 MQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRNYFIPKGTDIITSLTSVLHDE 377 Query: 426 AFFSSPDKFDPTRWLSKDKDLIHFRN----LGFGWGVRQCVGRRIAELEMTLFLIHILEN 481 F +P FDP +L + + F+ + F G R CVG +A +E+ LFL IL+N Sbjct: 378 KAFPNPKVFDPGHFLDESGN---FKKSDYFMPFSAGKRMCVGEGLARMELFLFLTSILQN 434 Query: 482 FKVE 485 FK++ Sbjct: 435 FKLQ 438 >3S79-A nrPDB Length = 503 Score = 68.2 bits (165), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 58/210 (27%), Positives = 105/210 (50%), Gaps = 11/210 (5%) Query: 313 EDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQM 372 E+V I EML +T S++L + L+ +A+ NV+E + +E+ + + I +Q Sbjct: 294 ENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDD-IQK 352 Query: 373 VPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPD 432 + +++ I E++R P+ + R D V+ Y + T + + I M R FF P+ Sbjct: 353 LKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPN 411 Query: 433 KFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEM---QHI 489 +F + +K+ +F+ FG+G R C G+ IA + M L+ +L F V+ Q + Sbjct: 412 EFTLENF-AKNVPYRYFQ--PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCV 468 Query: 490 GDVDTIFNLILTPDKP---IFLVFRPFNQD 516 + I +L L PD+ + ++F P N D Sbjct: 469 ESIQKIHDLSLHPDETKNMLEMIFTPRNSD 498 >4GQS-A nrPDB Length = 477 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 46/182 (25%), Positives = 86/182 (47%), Gaps = 2/182 (1%) Query: 306 KSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGD 365 + + +E++ ++L G TTS TL++ L + + V ++EE+ + Sbjct: 261 QQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSP 320 Query: 366 ISKMLQMVPLLKASIKETLR-LHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRD 424 + +P A + E R + I +L D+ ++YLIP T + ++ ++ D Sbjct: 321 CMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHD 380 Query: 425 PAFFSSPDKFDPTRWLSKDKDLIHFRN-LGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 F +P+ FDP +L + + + F G R CVG +A +E+ LFL IL+NF Sbjct: 381 NKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFN 440 Query: 484 VE 485 ++ Sbjct: 441 LK 442 >4H1N-A nrPDB Length = 479 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 54/180 (30%), Positives = 83/180 (46%), Gaps = 14/180 (7%) Query: 313 EDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNA----RRQAEGDISK 368 +++ + + A G TTS TL++ M + +V E +++E+ R A D +K Sbjct: 267 QNLILTVLSLFAAGTETTSTTLRYGFLLMLKYPHVTERVQKEIEQVIGSHRPPALDDRAK 326 Query: 369 MLQMVPLLKASIKETLRLHP-ISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAF 427 M P A I E RL I + D + Y+IP T V + + DP + Sbjct: 327 M----PYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRGYVIPKNTEVFPVLSSALHDPRY 382 Query: 428 FSSPDKFDPTRWLSKDKDLIHFRNLGF---GWGVRQCVGRRIAELEMTLFLIHILENFKV 484 F +P+ F+P +L + L RN GF G R C+G IA E+ LF IL+NF + Sbjct: 383 FETPNTFNPGHFLDANGALK--RNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSI 440 >2HI4-A nrPDB Length = 495 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 56/221 (25%), Positives = 101/221 (45%), Gaps = 14/221 (6%) Query: 278 EKYTEIFYQDLRRKTEFRNYPGILYCLLK-----SEKMLLEDVKAN-ITEMLAGGVNTTS 331 +K + YQD K R+ G L+ K S ++ ++ N + ++ G +T + Sbjct: 241 QKTVQEHYQDFD-KNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVT 299 Query: 332 MTLQWHLYEMARSLNVQEMLREEVLNA-RRQAEGDISKMLQMVPLLKASIKETLRLHP-I 389 + W L + +Q +++E+ R+ +S Q+ P L+A I ET R + Sbjct: 300 TAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQL-PYLEAFILETFRHSSFL 358 Query: 390 SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHF 449 T+ D L + IP K V V + + DP + P +F P R+L+ D I+ Sbjct: 359 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 418 Query: 450 ----RNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEM 486 + + FG G R+C+G +A+ E+ LFL +L+ + + Sbjct: 419 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSV 459 >3DL9-A nrPDB Length = 479 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 52/199 (26%), Positives = 92/199 (46%), Gaps = 14/199 (7%) Query: 313 EDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVL-----NARRQAEGDIS 367 E++ ++ E++ G TT+ L+W + MA N+Q +++E+ N + + D Sbjct: 272 ENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWD-DKC 330 Query: 368 KMLQMVPLLKASIKETLRL-HPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPA 426 KM P +A + E LR + + + + D V++ Y IP T V +Y++ D Sbjct: 331 KM----PYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEK 386 Query: 427 FFSSPDKFDPTRWLSKDKDLIHFRNL-GFGWGVRQCVGRRIAELEMTLFLIHILENFKVE 485 ++ P+ F P R+L L F G R C+G +A +EM LF +L+ F + Sbjct: 387 YWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLH 446 Query: 486 MQH--IGDVDTIFNLILTP 502 H + D+ + L P Sbjct: 447 FPHELVPDLKPRLGMTLQP 465 >2NNH-A nrPDB Length = 476 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 51/194 (26%), Positives = 91/194 (46%), Gaps = 11/194 (5%) Query: 312 LEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQ 371 +E++ + ++ G TTS TL++ L + + V ++EE+ + + + Sbjct: 266 IENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRS 325 Query: 372 MVPLLKASIKETLRLHPISVT-LQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSS 430 +P A + E R + T + +D ++YLIP T + + ++ D F + Sbjct: 326 HMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPN 385 Query: 431 PDKFDPTRWLSKD---KDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQ 487 P+ FDP +L K+ K +F + F G R C G +A +E+ LFL IL+NF ++ Sbjct: 386 PNIFDPGHFLDKNGNFKKSDYF--MPFSAGKRICAGEGLARMELFLFLTTILQNFNLK-- 441 Query: 488 HIGDVDTIFNLILT 501 VD + NL T Sbjct: 442 ---SVDDLKNLNTT 452 >3E6I-A nrPDB Length = 476 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 45/178 (25%), Positives = 83/178 (46%), Gaps = 6/178 (3%) Query: 312 LEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQ 371 ++ + + ++ G TTS TL++ L + + ++E L EE+ + K Q Sbjct: 265 MDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQ 324 Query: 372 MVPLLKASIKETLRLHPISVTLQRYPES---DLVLQDYLIPAKTLVQVAIYAMGRDPAFF 428 +P + A + E R I++ P D + + YLIP T+V + ++ D F Sbjct: 325 EMPYMDAVVHEIQRF--ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF 382 Query: 429 SSPDKFDPTRWLSKDKDLIHFRNLG-FGWGVRQCVGRRIAELEMTLFLIHILENFKVE 485 P+KF P +L+++ + F G R C G +A +E+ L L IL++F ++ Sbjct: 383 PDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 440 >3TBG-A nrPDB Length = 479 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 49/179 (27%), Positives = 84/179 (46%), Gaps = 14/179 (7%) Query: 313 EDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLN----ARRQAEGDISK 368 E+++ + ++ + G+ TTS TL W L M +VQ +++E+ + RR GD + Sbjct: 271 ENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAH 330 Query: 369 MLQMVPLLKASIKETLRLH---PISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDP 425 M P A I E R P+ VT D+ +Q + IP T + + ++ +D Sbjct: 331 M----PYTTAVIHEVQRFGDIVPLGVT--HMTSRDIEVQGFRIPKGTTLITNLSSVLKDE 384 Query: 426 AFFSSPDKFDPTRWLSKDKDLIHFRN-LGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 A + P +F P +L + L F G R C+G +A +E+ LF +L++F Sbjct: 385 AVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFS 443 >2W0A-A nrPDB Length = 455 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 46/176 (26%), Positives = 81/176 (46%), Gaps = 2/176 (1%) Query: 313 EDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQM 372 +++ M+ G +T+S T W L E+ R + + +E+ L+ Sbjct: 244 DEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQ 303 Query: 373 VPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPD 432 +P L+ +KETLRLHP + L R + + +Q + I LV + R P F P Sbjct: 304 IPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPH 363 Query: 433 KFDPTRWLS-KDKDLIH-FRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEM 486 F P R+ + +DL++ + + FG G +CVG A +++ +L ++ EM Sbjct: 364 DFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEM 419 >3R9C-A nrPDB Length = 418 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 35/106 (33%), Positives = 51/106 (48%), Gaps = 8/106 (7%) Query: 377 KASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDP 436 A I+ET+R P + RY DL + + +P + + + A RDP +PD+FDP Sbjct: 290 SAVIEETMRYDPPVQLVSRYAGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDP 349 Query: 437 TRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 R R+LGFG G C+G +A LE T+ L + F Sbjct: 350 DR--------AQIRHLGFGKGAHFCLGAPLARLEATVALPALAARF 387 >6DWN-A nrPDB Length = 491 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 50/192 (26%), Positives = 89/192 (46%), Gaps = 14/192 (7%) Query: 319 ITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREE----VLNARRQAEGDISKMLQMVP 374 + ++ G +T + + W L + + VQ ++EE + +RR D S + P Sbjct: 284 VLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHL----P 339 Query: 375 LLKASIKETLRLHP-ISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDK 433 ++A I ET R + T+ D L+ + IP V V + + D + +P + Sbjct: 340 YMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSE 399 Query: 434 FDPTRWLSKD---KDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILE--NFKVEMQH 488 F P R+L+ D ++ + + FG G R+C+G IA E+ LFL +L+ F V + Sbjct: 400 FLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGV 459 Query: 489 IGDVDTIFNLIL 500 D+ I+ L + Sbjct: 460 KVDMTPIYGLTM 471 >2WX2-A nrPDB Length = 473 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 71/358 (19%), Positives = 149/358 (41%), Gaps = 32/358 (8%) Query: 138 GVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGD 197 GV + ++++ E + +NF+P + + F++ + + V + Sbjct: 99 GVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMA------ENWKEDEGVIN 152 Query: 198 IKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRL 257 + ED + +FGE L + +N A+ F + KM + +P P L RL Sbjct: 153 LLEDCGAMIINTACQCLFGEDL---RKRLN--ARHFAQLLSKMESSLIPAAVFMPWLLRL 207 Query: 258 F--RTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKS-----EKM 310 ++ R+ A I + I ++ ++ N +L LLK+ +M Sbjct: 208 PLPQSARCREARAELQKILGEI-----IVAREKEEASKDNNTSDLLGGLLKAVYRDGTRM 262 Query: 311 LLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQ--EMLREEVLNARRQAEGDISK 368 L +V I + G +T+++T W + + N + + L +E+ Q D Sbjct: 263 SLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYD--N 320 Query: 369 MLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFF 428 ++ +P + ++E++R P + + R ++++ + Y++P ++ + D F Sbjct: 321 VMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAF 380 Query: 429 SSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEM 486 +P +DP R D I GFG GV +C+G++ A L++ L + ++ Sbjct: 381 PNPRLWDPERDEKVDGAFI-----GFGAGVHKCIGQKFALLQVKTILATAFREYDFQL 433 >2X2N-A nrPDB Length = 475 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 40/179 (22%), Positives = 84/179 (46%), Gaps = 9/179 (5%) Query: 310 MLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQ--EMLREEVLNARRQAEGDIS 367 M L +V I + G +T+S+T W + + NV+ E LR+E+ A+ + + Sbjct: 262 MSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEI--EEFPAQLNYN 319 Query: 368 KMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAF 427 ++ +P + +E++R P + L R +D+ + Y++P ++ + D Sbjct: 320 NVMDEMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLLSHHDEEA 379 Query: 428 FSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEM 486 F P ++DP R + + +GFG GV +C+G++ L++ L ++ ++ Sbjct: 380 FPEPRRWDPER-----DEKVEGAFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQL 433 >5E0E-A nrPDB Length = 463 Score = 61.6 bits (148), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 48/178 (26%), Positives = 81/178 (45%), Gaps = 10/178 (5%) Query: 313 EDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNA----RRQAEGDISK 368 +++ ++ + G T+S TL++ M + +V E +++E+ R D +K Sbjct: 258 QNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLEDRTK 317 Query: 369 MLQMVPLLKASIKETLRLHP-ISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAF 427 M P +A I E R I + + D + + YL+P T V + + DP + Sbjct: 318 M----PYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 373 Query: 428 FSSPDKFDPTRWLSKDKDLIHFRN-LGFGWGVRQCVGRRIAELEMTLFLIHILENFKV 484 F PD F+P +L + L + F G R C+G IA E+ LF IL+NF + Sbjct: 374 FEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSL 431 >3MGX-A nrPDB Length = 415 Score = 61.6 bits (148), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 49/200 (24%), Positives = 87/200 (43%), Gaps = 28/200 (14%) Query: 278 EKYTEIFYQDLRRKTEFRNYPG--ILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQ 335 + +TEI T R PG ++ L+ + + ++DV N +L GG TT + Sbjct: 205 QAHTEILVYFDELITARRKEPGDDLVSTLVTDDDLTIDDVLLNCDNVLIGGNETTRHAIT 264 Query: 336 WHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQR 395 ++ +A + L A R D+ + ++E LR ++ + R Sbjct: 265 GAVHALATVPGL--------LTALRDGSADVDTV----------VEEVLRWTSPAMHVLR 306 Query: 396 YPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFG 455 +D+ + +P+ T V + A RDPA F PD F P R + R++ FG Sbjct: 307 VTTADVTINGRDLPSGTPVVAWLPAANRDPAEFDDPDTFLPGRKPN--------RHITFG 358 Query: 456 WGVRQCVGRRIAELEMTLFL 475 G+ C+G +A +E+++ L Sbjct: 359 HGMHHCLGSALARIELSVVL 378 >2WIY-A nrPDB Length = 394 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 35/106 (33%), Positives = 51/106 (48%), Gaps = 6/106 (5%) Query: 378 ASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPT 437 A I E +R+ P ++ R+P D+ + LI A + ++ I A RDP F PD FD T Sbjct: 268 AIINEMVRMDPPQLSFLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHT 327 Query: 438 RWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 R + RNL FG G C G+ I+ E T + E ++ Sbjct: 328 RPPAAS------RNLSFGLGPHSCAGQIISRAEATTVFAVLAERYE 367 >3IBD-A nrPDB Length = 476 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 53/180 (29%), Positives = 80/180 (44%), Gaps = 14/180 (7%) Query: 313 EDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLR---EEVLNARRQAE-GDISK 368 +++ N + G TTS TL++ M + +V E + E+V+ R E D +K Sbjct: 267 QNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAK 326 Query: 369 MLQMVPLLKASIKETLR---LHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDP 425 M P +A I E R L P+ V + Y+IP T V + + DP Sbjct: 327 M----PYTEAVIYEIQRFSDLLPMGVP--HIVTQHTSFRGYIIPKDTEVFLILSTALHDP 380 Query: 426 AFFSSPDKFDPTRWLSKDKDLIHFRN-LGFGWGVRQCVGRRIAELEMTLFLIHILENFKV 484 +F PD F+P +L + L + F G R C+G IA E+ LF IL+NF + Sbjct: 381 HYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSM 440 >3EL3-A nrPDB Length = 467 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 102/466 (21%), Positives = 177/466 (37%), Gaps = 50/466 (10%) Query: 62 LYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERY 121 L H WR R + + +G + R KLG ++VY + ++ Y Sbjct: 34 LGHGWR---LARDPLAFMSQLRDHGDVVRIKLGP-KTVYAVTNPELTGALALNPDY--HI 87 Query: 122 DIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSL 181 P W + K GV ++ R + P + IP P+ ++ Sbjct: 88 AGPLWESLEGLLGKE-GVATANGPLHRRQR-----RTIQPAFRLDAIPAYGPIMEEEAHA 141 Query: 182 LHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMF 241 L +R + GK V D + F A V R + + ++ A++ A+ +F Sbjct: 142 LTERWQ---PGKTV-DATSESFRVA------VRVAARCLLRGQYMDERAERLCVALATVF 191 Query: 242 HTSVPLLNVP-PELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDL--RRKTEFRNYP 298 + VP LYRL R FN A + ++ R+ + Sbjct: 192 RGMYRRMVVPLGPLYRLPLPANRR---------FNDALADLHLLVDEIIAERRASGQKPD 242 Query: 299 GILYCLLKS-----EKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLRE 353 +L LL++ + + +++ + +L G T + T+ W L +A + +R+ Sbjct: 243 DLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRD 302 Query: 354 EV---LNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPA 410 EV R A D+ K+ I E +RL P L R ++ L Y IPA Sbjct: 303 EVEAVTGGRPVAFEDVRKLRHT----GNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPA 358 Query: 411 KTLVQVAIYAMGRDPAFFSSPDKFDPTRWL-SKDKDLIHFRNLGFGWGVRQCVGRRIAEL 469 + + YA+ RDP + +FDP RWL + ++ + F G R+C + Sbjct: 359 GADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMA 418 Query: 470 EMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQ 515 ++TL + ++ E Q G D + I +P L+ RP + Sbjct: 419 QLTLITAALATKYRFE-QVAGSNDAVRVGITL--RPHDLLVRPVAR 461 >5E58-A nrPDB Length = 493 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 48/178 (26%), Positives = 79/178 (44%), Gaps = 10/178 (5%) Query: 313 EDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNA----RRQAEGDISK 368 +++ ++ + G TTS TL++ M + +V E +++E+ R D +K Sbjct: 286 QNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLEDRTK 345 Query: 369 MLQMVPLLKASIKETLRLHPIS-VTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAF 427 M P A I E R ++ + D + + YL+P T V + + DP + Sbjct: 346 M----PYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 401 Query: 428 FSSPDKFDPTRWLSKDKDLIHFRN-LGFGWGVRQCVGRRIAELEMTLFLIHILENFKV 484 F P F+P +L + L + F G R C+G IA E+ LF IL+NF V Sbjct: 402 FEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSV 459 >3L4D-A nrPDB Length = 453 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 61/303 (20%), Positives = 124/303 (40%), Gaps = 33/303 (10%) Query: 197 DIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVP-------LLN 249 +I +D + +FGE L +A++F + KM +P +L Sbjct: 138 NILDDCSAMIINTACQCLFGEDL-----RKRLDARQFAQLLAKMESCLIPAAVFLPWILK 192 Query: 250 VP-PELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKS- 307 +P P+ YR RD A I ++ I ++ + N +L LL + Sbjct: 193 LPLPQSYRC------RDARAELQDILSEI-----IIAREKEEAQKDTNTSDLLAGLLGAV 241 Query: 308 ----EKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAE 363 +M +V I + G +T+++T W L + N + + + A+ Sbjct: 242 YRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEIDEFPAQ 301 Query: 364 GDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGR 423 + +++ +P + +E++R P V L R + + Y++P ++ + + Sbjct: 302 LNYDNVMEEMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDIIACSPLLSHQ 361 Query: 424 DPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 D F +P +++P R + L+ GFG GV +C+G + L++ L +L ++ Sbjct: 362 DEEAFPNPREWNPER----NMKLVDGAFCGFGAGVHKCIGEKFGLLQVKTVLATVLRDYD 417 Query: 484 VEM 486 E+ Sbjct: 418 FEL 420 >4WMZ-A nrPDB Length = 539 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 101/436 (23%), Positives = 183/436 (41%), Gaps = 57/436 (13%) Query: 80 ENFQKYGPIYR-EKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPI- 137 E +KYG I+ LG + +VY+ P+ H F F D+ AY + P+ Sbjct: 82 ECQKKYGDIFSFVLLGRVMTVYL-GPK--GHEFVFNAKLA---DVSAEAAY-AHLTTPVF 134 Query: 138 --GVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLL-NPVSQDFVSLLHKRIKQQGSGKF 194 GV++ + ++ + EA K+++PL+ V + F + R+ ++ +G Sbjct: 135 GKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTI 194 Query: 195 VGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPEL 254 D+ + + + G+ + +T +D + + P N+P E Sbjct: 195 --DVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFP--NLPLEH 250 Query: 255 YRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSE------ 308 YR RDH KA T + RRK ++ L+K+ Sbjct: 251 YRK------RDHA-------QKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGV 297 Query: 309 KMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDIS- 367 KM +++ + +L GG +T++ T W L +A +VQ+ L EE + + +++ Sbjct: 298 KMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTY 357 Query: 368 KMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQD--YLIPAKTLVQVAI-YAMGRD 424 +LQ +PLL +IKETLR+H +L R D+ + + Y+IPA V V+ Y RD Sbjct: 358 DLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRD 417 Query: 425 PAFFSSPDKFDPTRW---------LSKDKDL--------IHFRNLGFGWGVRQCVGRRIA 467 +F + +F+ RW + ++ D + L FG G +C+G A Sbjct: 418 -EYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFA 476 Query: 468 ELEMTLFLIHILENFK 483 ++ + + + K Sbjct: 477 YCQLGVLMSIFIRTLK 492 >5JLC-A nrPDB Length = 515 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 51/199 (25%), Positives = 84/199 (42%), Gaps = 27/199 (13%) Query: 309 KMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDIS- 367 KM +++ + +L GG +T++ T W L +A +VQE L +E + +++ Sbjct: 280 KMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQEQMRVLNNDTKELTY 339 Query: 368 KMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQD--YLIPAKTLVQVAIYAMGRDP 425 LQ +PLL IKETLRLH +L R D+ + + Y++P V V+ Sbjct: 340 DDLQNMPLLNQMIKETLRLHHPLHSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQE 399 Query: 426 AFFSSPDKFDPTRWLSKDKDLIHFRNLG---------------------FGWGVRQCVGR 464 FF P++F+ RW D D G FG G +C+G Sbjct: 400 EFFPKPNEFNIHRW---DGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGE 456 Query: 465 RIAELEMTLFLIHILENFK 483 A ++ + + + K Sbjct: 457 LFAYCQLGVLMSIFIRTMK 475 >6B11-A nrPDB Length = 440 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 40/136 (29%), Positives = 65/136 (47%), Gaps = 12/136 (8%) Query: 375 LLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKF 434 LL ++ E LR I+ L+R +D+ + + I A + + A RD A FS P+ F Sbjct: 311 LLPGAVDELLRYLSIADGLRRSATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAF 370 Query: 435 DPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDT 494 D R R++ FG+G QC+G+ +A +E+ + L +LE ++ DV Sbjct: 371 DIHRSAR--------RHVAFGYGPHQCLGQNLARMELEVALGAVLERLPA-LRPTTDV-- 419 Query: 495 IFNLILTPDKPIFLVF 510 L L D +F V+ Sbjct: 420 -AGLRLKSDSAVFGVY 434 >3SN5-A nrPDB Length = 491 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 56/198 (28%), Positives = 83/198 (41%), Gaps = 24/198 (12%) Query: 312 LEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDIS---- 367 LE K ++ + A NT T W L++M R+ + EEV A +S Sbjct: 256 LEKAKTHLVVLWASQANTIPATF-WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGN 314 Query: 368 ------KMLQMVPLLKASIKETLRLHPISVTLQRYPES-DLVLQD--YLIPAKTLVQVAI 418 L +P+L + IKE+LRL S+ ++ E L L+D Y I ++ + Sbjct: 315 PICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYP 374 Query: 419 YAMGRDPAFFSSPDKFDPTRWL---SKDKDLIHFRNLG-------FGWGVRQCVGRRIAE 468 M DP + P F R+L K K + L FG G C GR A Sbjct: 375 QLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAI 434 Query: 469 LEMTLFLIHILENFKVEM 486 E+ FLI +L F++E+ Sbjct: 435 HEIKQFLILMLSYFELEL 452 >1CPT-A nrPDB Length = 428 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 31/104 (29%), Positives = 52/104 (50%), Gaps = 8/104 (7%) Query: 380 IKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRW 439 + E +R + R +D ++ I + ++ + RD FS+PD+FD TR+ Sbjct: 304 VDEAVRWTAPVKSFMRTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITRF 363 Query: 440 LSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 + R+LGFGWG C+G+ +A+LEM +F +L K Sbjct: 364 PN--------RHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLK 399 >6F0B-A nrPDB Length = 395 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 69/296 (23%), Positives = 122/296 (41%), Gaps = 39/296 (13%) Query: 183 HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFH 242 H+R++ + +F+ E L E + V+ G L ET P+ AV Sbjct: 91 HRRLRGTIAREFLPKHIELLRPAIREIVQGVLDG-----LAETAPPQDMLEAFAVPVASA 145 Query: 243 TSVPLLNVPPELYRLFRTKTWRDHVAAWDT------IFNKAEKYTEIFYQDLRRKTEFRN 296 T LL +P E R T+ + V+A + +F +Y QD E Sbjct: 146 TVFRLLGIPAE-DRALLTRCVKGVVSAVGSEDEGAEVFRTLGEYIGGLVQDPSELPEDSL 204 Query: 297 YPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVL 356 ++ + +++ + I ++ GG +TT+ T+ L A L+ E Sbjct: 205 IRRLVTGPYQEKQLTFHETIGVILMLIVGGYDTTASTISLSLVSYA--------LQPEKF 256 Query: 357 NARRQAEGDISKMLQMVPLLKASIKETLRLHPIS-VTLQRYPESDLVLQDYLIPAKTLVQ 415 + + + + +PLL ++E LR H +S + L R D+ + + A +V Sbjct: 257 SV-------VHEHPERIPLL---VEELLRYHTVSQLGLGRIATEDVEVGGVTVRAGQMVV 306 Query: 416 VAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEM 471 A+ RD + F +PD+ D D ++GFG+G QCVG+ +A +E+ Sbjct: 307 AALPLANRDESVFPNPDELD--------FDRPSVPHVGFGYGPHQCVGQALARVEL 354 >4GGV-A nrPDB Length = 418 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 35/110 (31%), Positives = 56/110 (50%), Gaps = 8/110 (7%) Query: 375 LLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKF 434 L+ +I+E LR+ S L R ++ + +IP +V + + A RDP F+ P+ + Sbjct: 289 LVPGAIEEALRVLSPSAALARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVY 348 Query: 435 DPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKV 484 DPTR + HF GFG G+ C+G +A LE + L + + F V Sbjct: 349 DPTRDPNP-----HF---GFGRGIHFCLGAPLARLEGRVALNALFDRFPV 390 >3A1L-A nrPDB Length = 425 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 35/123 (28%), Positives = 56/123 (45%), Gaps = 9/123 (7%) Query: 361 QAEGDISKMLQMVP-LLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIY 419 +A D+ L+ P A+++E +R P + R+ D+ L D+ IP + V + Sbjct: 271 RAHRDVLDELRTTPESTPAAVEELMRYDPPVQAVTRWAYEDIRLGDHDIPRGSRVVALLG 330 Query: 420 AMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHIL 479 + RDPA F PD D R R +GFG G+ C+G +A E + L +L Sbjct: 331 SANRDPARFPDPDVLDVHRAAE--------RQVGFGLGIHYCLGATLARAEAEIGLRALL 382 Query: 480 ENF 482 + Sbjct: 383 DGI 385 >5FOI-A nrPDB Length = 408 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 69/281 (24%), Positives = 114/281 (40%), Gaps = 62/281 (22%) Query: 224 ETVNPEAQKFIDAVYK-----------MFHTSVP--------LLNVPPELYRLFRTKTWR 264 ET+ PE +K +D + + H ++P LL VP E F+ ++ Sbjct: 124 ETMRPEIEKIVDGILDRLLALEPPVDILTHLALPMSTQVICHLLGVPYEDREFFQERSEL 183 Query: 265 DHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYC-----LLKSEKMLLEDVKANI 319 D + E +R KT + G+L LLK E + +++ N Sbjct: 184 ASRPNDDRSMPALIELVEYLDGLVRTKTAHPDT-GLLGTAVTERLLKGE-ITHQELVNNA 241 Query: 320 TEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLR--EEVLNARRQAEGDISKMLQMVPLLK 377 +LA G T++ + +L+V +LR E R Q E L+ Sbjct: 242 VLLLAAGHETSANQV---------TLSVLTLLRHPETAAELREQPE-----------LMP 281 Query: 378 ASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFD-- 435 ++ E LR H I+ L+R +D+VL D+ I A + + + + D F + FD Sbjct: 282 NAVDELLRYHSIADGLRRAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIH 341 Query: 436 -PTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFL 475 P R ++ FG+G QC+G+ +A LEM + L Sbjct: 342 RPAR-----------HHVAFGYGPHQCLGQNLARLEMEVTL 371 >4Z5P-A nrPDB Length = 400 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 78/313 (24%), Positives = 123/313 (39%), Gaps = 49/313 (15%) Query: 183 HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFG-ERLGMLEETVNPEAQKFIDAVYKMF 241 H R+++ S F + + E ++ G ER G + V AQ F AV Sbjct: 94 HTRLRRLLSKAFTARRMGAMQSWLEELFAGLLDGVERTGHPADIVRDLAQPFTIAVI--- 150 Query: 242 HTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYT-----EIFYQDL---RRKTE 293 LL VP E F + W + + + T ++K E + + DL RR Sbjct: 151 ---CRLLGVPYEDRGRF--QHWSEVIMS-TTAYSKEEAVSADASIRAYLADLVSARRAAP 204 Query: 294 FRNYPGILYCLLKSEKMLLED--VKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEML 351 + G+L + L ED + +T +L G T++ L +Y + + +L Sbjct: 205 HDDLLGVLVSARDDDDRLTEDELITFGVT-LLVAGHETSAHQLGNMVYALLTHEDQLSLL 263 Query: 352 REEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPIS--VTLQRYPESDLVLQDYLIP 409 RE Q E LL +++E LR P+ V R D+ L + Sbjct: 264 RE-------QPE-----------LLPRAVEELLRFVPLGNGVGNARIALEDVELSGGTVR 305 Query: 410 AKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAEL 469 A V A RDP F PD+ D TR + +L FG G C+G ++A + Sbjct: 306 AGEGVVAAAVNANRDPRAFDDPDRLDITREKNP--------HLAFGHGAHYCLGAQLARM 357 Query: 470 EMTLFLIHILENF 482 E+ + + +LE F Sbjct: 358 ELRVAIGGLLERF 370 >1UE8-A nrPDB Length = 367 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 66/248 (26%), Positives = 102/248 (41%), Gaps = 45/248 (18%) Query: 247 LLNVPPELYRLFRTKTWRDHVA----AWDTIFNKAEKYTEIFY-----QDLRRKTEFRNY 297 +L + P++ ++ K W D VA D IF+ KY E+ D R+ E + Sbjct: 130 MLGINPDVKKV---KDWSDLVALRLGRADEIFSIGRKYLELISFSKKELDSRKGKEIVDL 186 Query: 298 PGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLN 357 G + SE LE I M+AG N T+ L + E N + +RE+ Sbjct: 187 TGKIANSNLSE---LEKEGYFILLMIAG--NETTTNLIGNAIEDFTLYNSWDYVREK--- 238 Query: 358 ARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVA 417 LKA ++E LR P + R + + ++D +I LV+V Sbjct: 239 ----------------GALKA-VEEALRFSPPVMRTIRVTKEKVKIRDQVIDEGELVRVW 281 Query: 418 IYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIH 477 I + RD F PD F P R + +L FG G+ C+G +A LE + L Sbjct: 282 IASANRDEEVFKDPDSFIPDRTPNP--------HLSFGSGIHLCLGAPLARLEARIALEE 333 Query: 478 ILENFKVE 485 + F+V+ Sbjct: 334 FAKKFRVK 341 >5FYF-A nrPDB Length = 470 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 58/227 (25%), Positives = 99/227 (43%), Gaps = 37/227 (16%) Query: 265 DHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGI-LYCLLKSEKMLLEDVK------A 317 D A +D + A ++ + ++D + PG L LL+S K + + Sbjct: 241 DENAMFDDAADMARSFSRL-WRDKEARRAAGEEPGFDLISLLQSNKETKDLINRPMEFIG 299 Query: 318 NITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLRE-EVLNARRQAEGDISKMLQMVPLL 376 N+T ++ GG +TT ++ L M E RE E L A+ + L+ Sbjct: 300 NLTLLIVGGNDTTRNSMSGGLVAM------NEFPREFEKLKAKPE-------------LI 340 Query: 377 KASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMG-RDPAFFSSPDKFD 435 + E +R ++R + D+ L I V V YA G RD F +PD+F Sbjct: 341 PNMVSEIIRWQTPLAYMRRIAKQDVELGGQTIKKGDRV-VMWYASGNRDERKFDNPDQFI 399 Query: 436 PTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 R +++ ++ FG+GV +C+G R+AEL++ + IL+ F Sbjct: 400 IDRKDARN-------HMSFGYGVHRCMGNRLAELQLRILWEEILKRF 439 >3TKT-A nrPDB Length = 450 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 35/106 (33%), Positives = 48/106 (45%), Gaps = 8/106 (7%) Query: 375 LLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKF 434 LL ++E +R R +D L I A + + A DPA F P KF Sbjct: 321 LLPGIVEEAIRWTTPVQHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKF 380 Query: 435 DPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILE 480 DPTR + R+L FG G QC+G +A LEM + L +L+ Sbjct: 381 DPTRPAN--------RHLAFGAGSHQCLGLHLARLEMRVLLDVLLD 418 >2RFC-A nrPDB Length = 343 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 62/249 (24%), Positives = 97/249 (38%), Gaps = 53/249 (21%) Query: 247 LLNVPPELYRLFRTKTWRDHVAA--WDTIFN-----KAEKYTEIFYQDLRRKTEFRNYPG 299 +L +P LF K W D++ D FN + EIF D G Sbjct: 110 ILGIPDSDMPLF--KLWSDYIIGNKRDENFNYVNNRMVSRLLEIFKSDSH---------G 158 Query: 300 ILYCL----LKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEV 355 I+ L LK+ K+ +++ I ++ GG TT+ + M R ++ + ++ Sbjct: 159 IINVLAGSSLKNRKLTMDEKIKYIMLLIIGGNETTTNLIG----NMIRVIDENPDIIDDA 214 Query: 356 LNARRQAEGDISKMLQMVPLLKASIKETLRLH-PISVTLQRYPESDLVLQDYLIPAKTLV 414 L R ++ETLR + PI R+ D + + I V Sbjct: 215 LKNR-----------------SGFVEETLRYYSPIQFLPHRFAAEDSYINNKKIKKGDQV 257 Query: 415 QVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLF 474 V + + RD FF PD F R +L FG G+ C+G +A LE ++ Sbjct: 258 IVYLGSANRDETFFDEPDLFKIGR---------REMHLAFGIGIHMCLGAPLARLEASIA 308 Query: 475 LIHILENFK 483 L IL +FK Sbjct: 309 LNDILNHFK 317 >6GK6-A nrPDB Length = 411 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 32/114 (28%), Positives = 56/114 (49%), Gaps = 10/114 (8%) Query: 375 LLKASIKETLRLH-PISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDK 433 L+ ++++E LR P ++ R+ D+ L +PA V + A RDP F PD+ Sbjct: 275 LVGSAVEEALRCEGPAELSTIRWSLEDIELFGARVPAGEGVAAGLLAANRDPQHFPDPDR 334 Query: 434 FDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF-KVEM 486 FD R + R++GFG G+ C+G +A +E + +L ++E+ Sbjct: 335 FDIGRSPN--------RHIGFGGGIHFCLGAMLARIEAAIAFSTLLRRLPRIEL 380 >3JUS-A nrPDB Length = 461 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 58/239 (24%), Positives = 102/239 (42%), Gaps = 19/239 (7%) Query: 282 EIFYQDL-RRKTEFRNYPGILYCLL----KSEKMLLED-VKANITEMLAGGVNTTSMTLQ 335 +IFY+ + +R+ IL LL K + L +D V + +L G +T+S T Sbjct: 214 DIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSA 273 Query: 336 WHLYEMARSLNVQEMLREEVLNARRQAEGDIS-KMLQMVPLLKASIKETLRLHPISVTLQ 394 W + +AR +Q+ E + ++ L+ + LL IKETLRL P + + Sbjct: 274 WMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMM 333 Query: 395 RYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKD-KDLIHFRNLG 453 R + + Y IP V V+ R + F+P R+L + F + Sbjct: 334 RMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVP 393 Query: 454 FGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIF------NLILTPDKPI 506 FG G +C+G A +++ +L ++ ++ +D F +I TP+ P+ Sbjct: 394 FGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL-----IDGYFPTVNYTTMIHTPENPV 447 >3NC3-A nrPDB Length = 441 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 52/187 (27%), Positives = 75/187 (40%), Gaps = 22/187 (11%) Query: 301 LYCLLKSEKMLL--EDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNA 358 + C + E M L +D+ A I +L TL +Y + LN E + + VL Sbjct: 243 ILCTSEYEGMALSDKDILALILNVLLAATEPADKTLALMIYHL---LNNPEQMND-VLAD 298 Query: 359 RRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAI 418 R L+ +I ETLR P + R D V+ I T+V I Sbjct: 299 R--------------SLVPRAIAETLRYKPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMI 344 Query: 419 YAMGRDPAFFSSPDKFDPTRWLSKDKDLIH--FRNLGFGWGVRQCVGRRIAELEMTLFLI 476 A RDP F PD F+ R K R+L FG G+ CVG A+ E+ + Sbjct: 345 GAANRDPEAFEQPDVFNIHREDLGIKSAFSGAARHLAFGSGIHNCVGTAFAKNEIEIVAN 404 Query: 477 HILENFK 483 +L+ + Sbjct: 405 IVLDKMR 411 >4UBS-A nrPDB Length = 393 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 32/108 (29%), Positives = 51/108 (47%), Gaps = 8/108 (7%) Query: 375 LLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKF 434 L+ A+++E LR I+ L R D+ + I A V A + RD A F+ PD Sbjct: 264 LMPAAVEELLRFLSIADGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDAL 323 Query: 435 DPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 D W + ++ FG+G+ QC+G+ +A EM + L + E Sbjct: 324 D---WHRSAR-----HHVAFGFGIHQCLGQNLARAEMEIALGTLFERL 363 >5VWS-A nrPDB Length = 393 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 62/249 (24%), Positives = 106/249 (42%), Gaps = 40/249 (16%) Query: 247 LLNVPPELYRLFRTKTWRDHVAAWD-----------TIFNKAEKYTEIFYQDLR-RKTEF 294 LL VPP LFRT W D + + T+ + + + R R+T Sbjct: 143 LLGVPPGDRHLFRT--WSDRLMSLQVENYADPELARTVAAAMTEMNDYLREHCRSRRTHP 200 Query: 295 RNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREE 354 R+ +L L+++E +E + ++ E+ VNT S+ L +A L ++ Sbjct: 201 RD--DLLTRLVQAE---VEGKRLDLEEV----VNTASLLL------LAGHLTTTVLIGNT 245 Query: 355 VLNARRQAEGDISKMLQMVP-LLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTL 413 +L E + K ++ P L+ A+++E+LRL + R D+ + IPA Sbjct: 246 MLCLWDHPEAE--KAVRADPSLIPAALEESLRLRSPFLQAGRVTTRDVTIAGETIPANRF 303 Query: 414 VQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTL 473 V I + D F P++FD R + ++ FG GV C+G ++ LE + Sbjct: 304 VMAWILSANHDDRRFPDPERFDLHRQTTG--------HIAFGHGVHFCLGAQLGRLEGRI 355 Query: 474 FLIHILENF 482 L +L F Sbjct: 356 ALERLLGRF 364 >3ABB-A nrPDB Length = 408 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 31/110 (28%), Positives = 52/110 (47%), Gaps = 8/110 (7%) Query: 366 ISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDP 425 I +L+ + ++E LR +S + R + D+ + I A V V+I M RD Sbjct: 266 IDVLLRDPGAVSGVVEELLRFTSVSDHIVRMAKEDIEVGGATIKAGDAVLVSITLMNRDA 325 Query: 426 AFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFL 475 + +PD FD R ++GFG G+ QC+G+ +A E+ + L Sbjct: 326 KAYENPDIFDARRNAR--------HHVGFGHGIHQCLGQNLARAELEIAL 367 >6HQG-A nrPDB Length = 425 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 48/203 (23%), Positives = 88/203 (43%), Gaps = 16/203 (7%) Query: 285 YQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEM--- 341 +++LRR+T F + Y + + + K ++ MLA G +T +M +L + Sbjct: 203 HENLRRQTLFE---CVDYFMRLWNERVNAPPKPDLISMLAHGESTKNMDRMEYLGNLILL 259 Query: 342 --ARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPES 399 + + + VL + + D K+ + L+ A + ET+R ++R + Sbjct: 260 IVGGNDTTRNTISGSVLALHQNPDQD-RKLRENPGLIPAMVSETIRWQTPLAYMRRRAKR 318 Query: 400 DLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVR 459 D L I V + + RD P+ + W+ + + H L FG+GV Sbjct: 319 DFELGGKTIREGDKVAMWYVSGNRDEEVIDRPNDY----WIERPRVRQH---LSFGFGVH 371 Query: 460 QCVGRRIAELEMTLFLIHILENF 482 +CVG R+AEL++ + IL F Sbjct: 372 RCVGNRLAELQLKIIWEEILARF 394 >4RM4-A nrPDB Length = 396 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 61/255 (23%), Positives = 103/255 (40%), Gaps = 50/255 (19%) Query: 247 LLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTE------------- 293 LL VP F K W D + + T +K+E+ + F ++ R K E Sbjct: 147 LLGVPSAHMEQF--KAWSDLLVS--TPKDKSEEAEKAFLEE-RDKCEEELAAFFAGIIEE 201 Query: 294 FRNYP--GILYCLLKSE----KMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNV 347 RN P I+ L+++E K+ E++ T +L G TT+ + +Y + + V Sbjct: 202 KRNKPEQDIISILVEAEETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGV 261 Query: 348 QEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYL 407 E LR L+ +++E LR + L+R + D + +L Sbjct: 262 YEELRSHP------------------ELMPQAVEEALRFRAPAPVLRRIAKRDTEIGGHL 303 Query: 408 IPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIA 467 I +V + + RD A F P FD R + ++ FG G+ C+G +A Sbjct: 304 IKEGDMVLAFVASANRDEAKFDRPHMFDIRRHPNP--------HIAFGHGIHFCLGAPLA 355 Query: 468 ELEMTLFLIHILENF 482 LE + L ++ F Sbjct: 356 RLEANIALTSLISAF 370 >2WIO-A nrPDB Length = 431 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 46/107 (42%), Gaps = 6/107 (5%) Query: 376 LKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFD 435 + A ++E LR P +QR + IPA +V + + RD PD+FD Sbjct: 294 IPAIVEEVLRYRPPFPQMQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFD 353 Query: 436 PTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 P+R L FG GV C+G +A LE + L I+ F Sbjct: 354 PSRKSGGAA------QLSFGHGVHFCLGAPLARLENRVALEEIIARF 394 >1EHE-A nrPDB Length = 403 Score = 48.5 bits (114), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 28/105 (26%), Positives = 53/105 (50%), Gaps = 9/105 (8%) Query: 380 IKETLRLHPIS-VTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTR 438 ++E R H S + ++R + D+++ D L+ A + + + RD F +PD+F+ R Sbjct: 276 VEELCRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNR 335 Query: 439 -WLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 W +D LGFG+G +C+ +A+ E+T + + F Sbjct: 336 KWPPQDP-------LGFGFGDHRCIAEHLAKAELTTVFSTLYQKF 373 >6HQW-A nrPDB Length = 445 Score = 48.1 bits (113), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 46/199 (23%), Positives = 92/199 (46%), Gaps = 29/199 (14%) Query: 300 ILYCLLKSEKM---LLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVL 356 ++ ++ SE M ++ N+ ++ GG +TT T+ ++ + + + +E+L Sbjct: 255 LISMMIHSEAMNHMSPQEFMGNLVLLIVGGNDTTRNTMSGIVHALDKFPDQRELL----- 309 Query: 357 NARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQV 416 E D S L+ +++E +R ++R +D L I A V + Sbjct: 310 ------ERDAS-------LIPNAVQECIRYVTPLAHMRRTATADTELFGNQIKAGEKVIL 356 Query: 417 AIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLI 476 + RD F +PDK R ++ R+L FG G+ +CVG R+AEL++ + L Sbjct: 357 WYISANRDETVFENPDKLMVDRPNAR-------RHLSFGHGIHRCVGARLAELQLRILLE 409 Query: 477 HILENFKVEMQHIGDVDTI 495 + E ++ ++ G+V+ + Sbjct: 410 EMHER-RMRVRVAGEVERV 427 >4YZR-A nrPDB Length = 405 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 29/123 (23%), Positives = 59/123 (47%), Gaps = 9/123 (7%) Query: 361 QAEGDISKMLQMVPLLKASIKETLR-LHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIY 419 Q + + K+ Q ++ +++E LR P+ + R+ D + + I ++ + I Sbjct: 259 QHKKECEKLKQQPEMIATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIG 318 Query: 420 AMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHIL 479 + RDP FF +P+ + R + R++ FG+G+ C+G +A LE + +L Sbjct: 319 SANRDPNFFENPEILNINRSPN--------RHISFGFGIHFCLGAPLARLEGHIAFKALL 370 Query: 480 ENF 482 + F Sbjct: 371 KRF 373 >5NWS-A nrPDB Length = 435 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 31/109 (28%), Positives = 50/109 (45%), Gaps = 5/109 (4%) Query: 375 LLKASIKETLR-LHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDK 433 LL ++ E +R + V RY DL L + VQ+ + + DP +S PD+ Sbjct: 299 LLPRAVHELMRWCGSVHVARLRYATEDLELAGTPVARGDAVQLVLVSANFDPRHYSDPDR 358 Query: 434 FDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 D TR + ++GFG G+ C+G +A E + L +LE + Sbjct: 359 LDITRHQEGQAE----NHVGFGHGIHYCLGATLARQEGEVALARLLETY 403 >1UED-A nrPDB Length = 406 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 64/274 (23%), Positives = 103/274 (37%), Gaps = 48/274 (17%) Query: 207 FESITNVMFGERLGMLE-ETVNPEAQK-FIDAVYKMFHTSVPLLNVPPELYRLFRTKTWR 264 E + +RL +LE E + + Q F D V H LL +P + R F + R Sbjct: 124 MEPAIQSLIDDRLDLLEAEGPSADLQGLFADPVGA--HALCELLGIPRDDQREFVRRIRR 181 Query: 265 DH--------VAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLK--SEKMLLED 314 + AA FN+ + +L + G+L +++ + + E+ Sbjct: 182 NADLSRGLKARAADSAAFNR-------YLDNLLARQRADPDDGLLGMIVRDHGDNVTDEE 234 Query: 315 VKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVP 374 +K T ++ GGV T + + + + + + E+L E A R Sbjct: 235 LKGLCTALILGGVETVAGMIGFGVLALLDNPGQIELLFESPEKAER-------------- 280 Query: 375 LLKASIKETLR-LHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDK 433 + E +R L P+ R D+V+ LI A V +I RD A PD Sbjct: 281 ----VVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPDV 336 Query: 434 FDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIA 467 D R D +GFG G+ CVG +A Sbjct: 337 LDANRAAVSD--------VGFGHGIHYCVGAALA 362 >3A50-A nrPDB Length = 411 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 33/108 (30%), Positives = 52/108 (48%), Gaps = 10/108 (9%) Query: 365 DISKMLQMVP-LLKASIKETLRL-HPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMG 422 D K+L P L+ ++++E LR P+S R+ D+ IPA +V + + A Sbjct: 257 DQRKLLAEDPSLISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAAN 316 Query: 423 RDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELE 470 RD + PD+ D TR S + FG G+ C+G ++A LE Sbjct: 317 RDADWMPEPDRLDITRDASG--------GVFFGHGIHFCLGAQLARLE 356 >6CR2-A nrPDB Length = 477 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 43/182 (23%), Positives = 81/182 (44%), Gaps = 26/182 (14%) Query: 313 EDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKM--- 369 E++ + +L G +++S T W + +A ++ E L +E + R D+ + Sbjct: 249 EEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQI---RVLGSDLPPLTYD 305 Query: 370 -LQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQ--DYLIPAKTLVQVAIYAMGRDPA 426 LQ + L IKETLRLH ++ R ++ + + Y+IP V + R Sbjct: 306 NLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEE 365 Query: 427 FFSSPDKFDPTRW------LSKDKDLIHFR-----------NLGFGWGVRQCVGRRIAEL 469 F +P +++P RW ++D + + + L FG G +C+G + A L Sbjct: 366 HFPNPLEWNPHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYL 425 Query: 470 EM 471 ++ Sbjct: 426 QL 427 >5LIE-A nrPDB Length = 414 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 8/108 (7%) Query: 375 LLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKF 434 LL +I+E +R S + +R + L I A V V + RDP+ F D+F Sbjct: 285 LLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEF 344 Query: 435 DPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 D TR + +LGFG GV C+G +A LE+ + +L F Sbjct: 345 DITRKPNP--------HLGFGQGVHYCLGANLARLELRVLFEELLSRF 384 >3TYW-A nrPDB Length = 417 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 30/106 (28%), Positives = 52/106 (49%), Gaps = 9/106 (8%) Query: 375 LLKASIKETLRLHPISVTLQ-RYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDK 433 L+ A++ E LR+ ++ ++ R D+ L +PA V + DP F P++ Sbjct: 281 LMPAAVDELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPER 340 Query: 434 FDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHIL 479 D R + ++ FG+GV QCVG+ +A LE+ + L +L Sbjct: 341 VDFHRTDNH--------HVAFGYGVHQCVGQHLARLELEVALETLL 378 >1GWI-A nrPDB Length = 411 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 34/108 (31%), Positives = 52/108 (48%), Gaps = 9/108 (8%) Query: 377 KASIKETLRLH-PISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDP-AFFSSPDKF 434 A ++ETLR P S L R+ D+ + D +IPA + V+ A+GRD A + D+F Sbjct: 276 SAVVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADRF 335 Query: 435 DPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 D TR R++ FG G C G ++ +E + L + F Sbjct: 336 DLTRTSGN-------RHISFGHGPHVCPGAALSRMEAGVALPALYARF 376 >5XW2-A nrPDB Length = 419 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 33/109 (30%), Positives = 55/109 (50%), Gaps = 10/109 (9%) Query: 375 LLKASIKETLR-LHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDK 433 L+ ++E++R L P++ T R D+ + + A +V V A RD F+ P+ Sbjct: 288 LIPGLLEESMRFLSPVAATY-RATTRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPEL 346 Query: 434 FDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 FD TR + +LGFG G+ C+G +A +E + L H+L+ F Sbjct: 347 FDMTRGPNP--------HLGFGRGIHFCLGGPLARMEGRVALDHLLDRF 387 >5HDI-A nrPDB Length = 404 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 40/128 (31%), Positives = 59/128 (46%), Gaps = 9/128 (7%) Query: 365 DISKMLQMVP-LLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGR 423 DI + ++ P LL A I+ETLR P R+ + L +PA + + + A R Sbjct: 265 DIQQQVRANPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANR 324 Query: 424 DPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 DPA F +P +F R K ++ FG G CVG +A LE + L +L+ Sbjct: 325 DPAQFEAPGEFRLDRAGGKG-------HISFGKGAHFCVGAALARLEARIVLRLLLDRTS 377 Query: 484 V-EMQHIG 490 V E +G Sbjct: 378 VIEAADVG 385 >1Z8P-A nrPDB Length = 404 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 33/107 (30%), Positives = 49/107 (45%), Gaps = 8/107 (7%) Query: 376 LKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFD 435 L +++E LR T R+ ++ + IP + V VA A RDP F P +FD Sbjct: 274 LPNAVEEILRYIAPPETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRFD 333 Query: 436 PTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 TR +L FG G+ C+GR +A+LE + L + F Sbjct: 334 VTRDTRG--------HLSFGQGIHFCMGRPLAKLEGEVALRALFGRF 372 >6GMF-A nrPDB Length = 397 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 35/134 (26%), Positives = 64/134 (47%), Gaps = 22/134 (16%) Query: 362 AEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAM 421 A+ D+S L+ A ++E LR + + R +D+ + D IPA+++V + + Sbjct: 259 AQADLS-------LVPAVVEEVLRYESPAQCIFRQTMTDVEIGDERIPARSVVLPLLASA 311 Query: 422 GRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILEN 481 RD + F PD+FD + +D +L FG + C+G +A LE + L Sbjct: 312 NRDESRFPDPDRFD----IHRDTK----GHLAFGLDIHFCIGAPLARLEAKVML------ 357 Query: 482 FKVEMQHIGDVDTI 495 +V + +GD+ + Sbjct: 358 -EVLLARLGDIQRV 370 >5CJE-A nrPDB Length = 393 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 32/108 (29%), Positives = 46/108 (42%), Gaps = 9/108 (8%) Query: 375 LLKASIKETLRLH-PISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDK 433 LL +++E LR P+ RY + + I V + + A GRDPA P Sbjct: 265 LLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPVMIGLDAAGRDPARHPDPHV 324 Query: 434 FDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILEN 481 FD R +L FG G+ C+G +A LE + L +LE Sbjct: 325 FDIHRAPQG--------HLAFGHGIHYCLGAPLARLEARVALRSLLER 364 >2VZM-A nrPDB Length = 436 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 49/107 (45%), Gaps = 9/107 (8%) Query: 375 LLKASIKETLRLH-PISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDK 433 LL +++E LR P+ R+P + L +IPA V V + R P F P + Sbjct: 295 LLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHR 354 Query: 434 FDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILE 480 FD R + +L FG G+ C+G +A LE + + +LE Sbjct: 355 FDIRRDTAG--------HLAFGHGIHFCIGAPLARLEARIAVRALLE 393 >1WIY-A nrPDB Length = 389 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 32/106 (30%), Positives = 52/106 (49%), Gaps = 3/106 (2%) Query: 380 IKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRW 439 +E LRL+P + L R E L+L + +P T + ++ Y R +F + F P R+ Sbjct: 258 FQEALRLYPPAWILTRRLERPLLLGEDRLPQGTTLVLSPYVTQR--LYFPEGEAFQPERF 315 Query: 440 LSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVE 485 L+ ++ R FG G R C+GR A LE + L F+++ Sbjct: 316 LA-ERGTPSGRYFPFGLGQRLCLGRDFALLEGPIVLRAFFRRFRLD 360 >6A7I-A nrPDB Length = 411 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 63/286 (22%), Positives = 119/286 (41%), Gaps = 35/286 (12%) Query: 200 EDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELY-RLF 258 E L + + E + + GE + + E P I + + P L EL+ + F Sbjct: 120 EALTNASLEKLAALPAGEPVDLKAEFAYPLPMNVISELMGVDAADHPRLK---ELFEKFF 176 Query: 259 RTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKAN 318 T+T + V + + +T+I D +R + L ++ L ++ N Sbjct: 177 STQTPPEEVP--QMMADLGALFTKIV--DAKRTNPGDDLTSALIAASENGDHLTDEEIVN 232 Query: 319 ITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKA 378 +++ + T+++L ++ E +L R++VLN +G Sbjct: 233 TLQLIIAAGHETTISLIVNVVE---ALQTHPEQRKKVLNGEIGWDG-------------- 275 Query: 379 SIKETLRLH-PISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFS-SPDKFDP 436 I+ETLR + P S L R+ D+ + D ++P + ++ A+GRD + + +FD Sbjct: 276 VIEETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGALGRDEEQYGPTAGEFDA 335 Query: 437 TRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 TR + R++ FG G C G ++ LE + L + E F Sbjct: 336 TRTPN--------RHIAFGHGPHVCPGAALSRLEAGIALPALYERF 373 >3OFT-A nrPDB Length = 396 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 63/311 (20%), Positives = 111/311 (35%), Gaps = 58/311 (18%) Query: 165 KNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEE 224 F+ L P Q L + ++ +GS FV D E L F ++ +V +R Sbjct: 107 SRFVVALEPKVQAVARKLMESLRPRGSCDFVSDFAEILPLNIFLTLIDVPLEDR------ 160 Query: 225 TVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIF 284 P L +L T D + + A+ Y F Sbjct: 161 ---------------------------PRLRQLGVQLTRPDGSMTVEQLKQAADDYLWPF 193 Query: 285 YQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARS 344 + + + IL + +++ + +L GG++T + + +AR Sbjct: 194 IEKRMAQPGDDLFSRILSEPVGGRPWTVDEARRMCRNLLFGGLDTVAAMIGMVALHLARH 253 Query: 345 LNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQ 404 Q +LRE L+ A+ E +R +P +V + R +D+ Sbjct: 254 PEDQRLLRERP------------------DLIPAAADELMRRYP-TVAVSRNAVADVDAD 294 Query: 405 DYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGR 464 I LV + DPA F +P++ + D+ L R+ G G +CVG Sbjct: 295 GVTIRKGDLVYLPSVLHNLDPASFEAPEE------VRFDRGLAPIRHTTMGVGAHRCVGA 348 Query: 465 RIAELEMTLFL 475 +A +E+ +FL Sbjct: 349 GLARMEVIVFL 359 >2FR7-A nrPDB Length = 412 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 41/183 (22%), Positives = 74/183 (40%), Gaps = 26/183 (14%) Query: 296 NYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEV 355 + ++ + ++ E+ + +L+ G++TT + +Y +AR + LR + Sbjct: 222 GFGACIHAFSDTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRADP 281 Query: 356 LNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQ 415 AR + +E +R T R D+ L I V Sbjct: 282 SLARN------------------AFEEAVRFESPVQTFFRTTTRDVELAGATIGEGEKVL 323 Query: 416 VAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFL 475 + + + RDP + PD++D TR S ++GFG GV CVG+ +A LE + L Sbjct: 324 MFLGSANRDPRRWDDPDRYDITRKTSG--------HVGFGSGVHMCVGQLVARLEGEVVL 375 Query: 476 IHI 478 + Sbjct: 376 AAL 378 >2Y5N-A nrPDB Length = 417 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 33/117 (28%), Positives = 55/117 (47%), Gaps = 10/117 (8%) Query: 368 KMLQMVPLLKASIKETLRLHPISV--TLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDP 425 ++L L+ ++++E R P+ V RY D+ L+ I A V + A RD Sbjct: 279 QLLDRPELIPSAVEELTRWVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQ 338 Query: 426 AFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 A F D+ D R ++ +LGFG GV C+G +A +E+ + L +L+ Sbjct: 339 AQFPDADRIDVDRTPNQ--------HLGFGHGVHHCLGAPLARVELQVALEVLLQRL 387 >5L1U-A nrPDB Length = 401 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 31/102 (30%), Positives = 47/102 (46%), Gaps = 11/102 (10%) Query: 375 LLKASIKETLRL----HPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSS 430 L A+++E LRL + + RY D+ + + +I V +AI A D F Sbjct: 267 LAPAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPD 326 Query: 431 PDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMT 472 FD TR + +L FG G R C+GR +A +E+T Sbjct: 327 GGLFDLTRVRPRS-------HLAFGHGARHCIGRTLARIELT 361 >4JBT-A nrPDB Length = 410 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 84/207 (40%), Gaps = 36/207 (17%) Query: 284 FYQDLRRKTEFRNYPG------ILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWH 337 F + +RRKT PG ++Y + E+V N+ ++A G TT Sbjct: 200 FTEMVRRKTA---EPGDDLTSALIYATDGETPLTEEEVIGNLQALVAAGHETT------- 249 Query: 338 LYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLH-PISVTLQRY 396 ++ L L R +G+I + +I+ETLR P+ L R+ Sbjct: 250 ---VSLILTAVRALLSHPEQLRLVRDGEIG--------WETAIEETLRWDGPVIHLLMRF 298 Query: 397 PESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSS-PDKFDPTRWLSKDKDLIHFRNLGFG 455 D+ L D +IP V ++ A+GRD + D FD TR + R++ FG Sbjct: 299 ATEDIDLGDAVIPRGEGVVMSYRAIGRDITVHGADADDFDITRATAA-------RHISFG 351 Query: 456 WGVRQCVGRRIAELEMTLFLIHILENF 482 G C G +A LE + L + F Sbjct: 352 HGPHICPGAALARLEAAIALPALFTRF 378 >4DO1-A nrPDB Length = 410 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 40/157 (25%), Positives = 66/157 (42%), Gaps = 26/157 (16%) Query: 319 ITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKA 378 + +L+ G++TT + +Y +AR + LR + AR Sbjct: 243 VRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRSDPTLARN------------------ 284 Query: 379 SIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTR 438 + +E +R T R ++ L +I V + + + RDP +S PD +D TR Sbjct: 285 AFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITR 344 Query: 439 WLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFL 475 S ++GFG GV CVG+ +A LE + L Sbjct: 345 KTSG--------HVGFGSGVHMCVGQLVARLEGEVML 373 >6GII-A nrPDB Length = 479 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 24/101 (23%), Positives = 48/101 (47%), Gaps = 7/101 (6%) Query: 375 LLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKF 434 L+ A+ +E LR + +R ++ ++ +P + + + + D A F P+ F Sbjct: 340 LIPAAAEECLRYNGPVAGWRRRTTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFF 399 Query: 435 DPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFL 475 D R + + +L FG+G QC+GR + +EM + + Sbjct: 400 DIGRSNASE-------HLNFGYGAHQCLGRNLGRMEMQIMI 433 >5OFQ-A nrPDB Length = 409 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 47/203 (23%), Positives = 84/203 (41%), Gaps = 35/203 (17%) Query: 300 ILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNAR 359 +L + E + E+V +L G TT+ + + M ++VQ +R ++ Sbjct: 216 LLEAEIDGEHLTEEEVLGFCILLLVAGNETTTNLITNGVRYMTEDVDVQNEVRRDI---- 271 Query: 360 RQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIY 419 +VP L ++ETLR +P + R D+ L + I V Sbjct: 272 -----------SLVPNL---VEETLRYYPPIQAIGRIAAEDVELGECKIKRGQQVISWAA 317 Query: 420 AMGRDPAFFSSPDKFDPTRWLSKDKDLIHFR---NLGFGWGVRQCVGRRIAELEMTLFLI 476 + RD A F PD F ++H + ++ FG+G+ C+G +A +E + Sbjct: 318 SANRDSAKFEWPDTF-----------VVHRKTNPHVSFGFGIHFCLGAPLARMEGKIAFT 366 Query: 477 HILEN---FKVEMQHIGDVDTIF 496 +LE KV+ Q + +D+ F Sbjct: 367 KLLEKGGFSKVQNQSLKPIDSPF 389 >5Z9I-A nrPDB Length = 398 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 8/96 (8%) Query: 375 LLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKF 434 L+ A ++E++R + R S++ + +IP L+ V A RD F PD F Sbjct: 269 LVPALLEESMRYMSPICGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVF 328 Query: 435 DPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELE 470 D R + +LGFG G+ C+GR++A +E Sbjct: 329 DAGRSPNA--------HLGFGRGIHFCLGRQLARME 356 >1F4U-A nrPDB Length = 368 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 83/341 (24%), Positives = 137/341 (40%), Gaps = 70/341 (20%) Query: 183 HKRIKQQGSGKFVGDI--------KEDLFHFAFESITNVMFG-ERLGMLEETVNPEAQKF 233 H+R++ +GK DI + H S++ +F ++L LE + + Sbjct: 47 HERLEDLRNGKIRFDIPTRYTMLTSDPPLHDELRSMSADIFSPQKLQTLETFIRETTRSL 106 Query: 234 IDAV-------YKMFHTSVPL------LNVPPELYRLFRTKTWRDHVA----AWDTIFNK 276 +D++ K +P+ L +P E F K W D VA IF Sbjct: 107 LDSIDPREDDIVKKLAVPLPIIVISKILGLPIEDKEKF--KEWSDLVAFRLGKPGEIFEL 164 Query: 277 AEKYTEI--FYQD-LRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMT 333 +KY E+ + +D L TE ++ ++ S +E + I ++AG TT++ Sbjct: 165 GKKYLELIGYVKDHLNSGTE------VVSRVVNSNLSDIEKLGYIILLLIAGNETTTNL- 217 Query: 334 LQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTL 393 + + + R N+ + +REE L LKA I+E LR P + Sbjct: 218 ISNSVIDFTR-FNLWQRIREENL------------------YLKA-IEEALRYSPPVMRT 257 Query: 394 QRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLG 453 R + + L D I V+V I + RD F +KF P R + +L Sbjct: 258 VRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVFHDGEKFIPDRNPNP--------HLS 309 Query: 454 FGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDT 494 FG G+ C+G +A LE + +E F +HI +DT Sbjct: 310 FGSGIHLCLGAPLARLEARI----AIEEFSKRFRHIEILDT 346 >3EJB-B nrPDB Length = 404 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 29/106 (27%), Positives = 49/106 (46%), Gaps = 8/106 (7%) Query: 375 LLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKF 434 L+ +++E LR + R D+ + I V + + A RDP+ F++PD F Sbjct: 266 LIGTAVEECLRYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVF 325 Query: 435 DPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILE 480 D TR + +L FG G C+G +A LE + + +L+ Sbjct: 326 DITRSPNP--------HLSFGHGHHVCLGSSLARLEAQIAINTLLQ 363 >1ODO-A nrPDB Length = 408 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 35/105 (33%), Positives = 50/105 (47%), Gaps = 10/105 (9%) Query: 380 IKETLRLHPISVTLQ-RYPESDLVLQDYLIPAKTLVQVAIYAMG-RDPAFFSSPDKFDPT 437 ++ETLR P L RY +D+ L D A+ +A YA R P + D FD T Sbjct: 279 VEETLRHEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADTFDAT 338 Query: 438 RWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 R + + +L FG GV C+G +A +E+TL L + F Sbjct: 339 RTVKE--------HLAFGHGVHFCLGAPLARMEVTLALESLFGRF 375 >6G71-A nrPDB Length = 405 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 53/210 (25%), Positives = 89/210 (42%), Gaps = 41/210 (19%) Query: 273 IFNKAEKYTEIFYQDLRRKTEFRN-YPG--ILYCLLKSE--KMLLEDVKANITEMLAGGV 327 ++ KA++ ++ L ++ + PG +L LL+S +M LE +++NI + GG+ Sbjct: 179 VWAKAKQSSDEIDAALEEMIQWHSGRPGDSLLSYLLRSADYQMPLESIRSNIKMTIGGGL 238 Query: 328 NTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMV----PLLKASIKET 383 N +VL A SK L++V L A +E+ Sbjct: 239 NEP----------------------RDVLGVSTLALLSSSKQLELVLRDPKLWGAVFEES 276 Query: 384 LR-LHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSK 442 +R + PI + + R D L Y IP + + I + RD + +S PD+FD R Sbjct: 277 IRWVAPIGM-VPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRFDIERGSEA 335 Query: 443 DKDLIHFRNLGFGWGVRQCVGRRIAELEMT 472 +L FG GV C+G A ++ Sbjct: 336 --------HLAFGKGVHVCLGAWAARSQVA 357 >2ZBZ-A nrPDB Length = 412 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 30/107 (28%), Positives = 51/107 (47%), Gaps = 9/107 (8%) Query: 375 LLKASIKETLRLHPIS-VTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDK 433 L+ +++E LR I+ + R +D+ ++ LI A V V RD + PD Sbjct: 276 LVPGAVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTVYEDPDA 335 Query: 434 FDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILE 480 D R +L FG+GV QC+G+ +A LE+ + L +++ Sbjct: 336 LDIHRSARH--------HLAFGFGVHQCLGQNLARLELEVILNALMD 374 >3ABA-A nrPDB Length = 403 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 29/100 (29%), Positives = 48/100 (48%), Gaps = 9/100 (9%) Query: 375 LLKASIKETLRLHPIS-VTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDK 433 L+ +++E LR I +R D+ L I V + A DPAF P++ Sbjct: 269 LVGNAVEELLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPER 328 Query: 434 FDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTL 473 FD TR + +L FG+G QC+G+++A +E+ + Sbjct: 329 FDITRRPAP--------HLAFGFGAHQCIGQQLARIELQI 360 >3P3Z-A nrPDB Length = 416 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 40/160 (25%), Positives = 69/160 (43%), Gaps = 26/160 (16%) Query: 314 DVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMV 373 +++ + +L G TT+ L +Y+ A+ + Q M K+ + Sbjct: 242 ELRTLVATVLVAGYETTNHQLALAMYDFAQHPD-QWM-----------------KIKENP 283 Query: 374 PLLKASIKETLRLHP-ISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPD 432 L +++E LR P + VT R D + IP T V + + RDP F+ D Sbjct: 284 ELAPQAVEEVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADAD 343 Query: 433 KFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMT 472 +FD T + ++ ++ FG G C+G +A LE+T Sbjct: 344 RFDIT--VKREAP-----SIAFGGGPHFCLGTALARLELT 376 >3WVS-A nrPDB Length = 401 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 34/127 (26%), Positives = 60/127 (47%), Gaps = 11/127 (8%) Query: 368 KMLQMVPLLKASIKETLRLHPISV--TLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDP 425 ++L L+ ++++E R P+ RY D+ + L+ A V VA+ A RD Sbjct: 266 RLLDDPELIPSAVEELFRFVPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVALGAANRDG 325 Query: 426 AFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVE 485 F P++ + D+ H ++GFG G+ C+G +A LE+ L +LE Sbjct: 326 LRFEDPEE------IKLDRPSNH--HIGFGHGIHHCLGAPLARLELQEALRALLERLPT- 376 Query: 486 MQHIGDV 492 ++ GD+ Sbjct: 377 LKVAGDI 383 >4OQS-A nrPDB Length = 433 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 24/91 (26%), Positives = 42/91 (46%), Gaps = 7/91 (7%) Query: 392 TLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRN 451 T R D+ L+ +I V + + A+ RDP F PD R ++ ++ Sbjct: 286 TPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDRVDAR-------KH 338 Query: 452 LGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 FG G+ QC+G+++A +EM + + F Sbjct: 339 AAFGGGIHQCLGQQLARVEMRIGFTRLFARF 369 >4OQR-A nrPDB Length = 457 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 24/91 (26%), Positives = 42/91 (46%), Gaps = 7/91 (7%) Query: 392 TLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRN 451 T R D+ L+ +I V + + A+ RDP F PD R ++ ++ Sbjct: 325 TPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDRVDAR-------KH 377 Query: 452 LGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 FG G+ QC+G+++A +EM + + F Sbjct: 378 AAFGGGIHQCLGQQLARVEMRIGFTRLFARF 408 >5H1Z-A nrPDB Length = 407 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 42/181 (23%), Positives = 79/181 (43%), Gaps = 28/181 (15%) Query: 298 PGILYCLLKSEKMLLEDVK---ANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREE 354 P ++ ++ S+ M D N+ ++ GG +TT T+ Y + + Sbjct: 215 PDLISMMIHSDAMAEMDQMEFLGNLILLIVGGNDTTRNTMSAVAYGL-----------DL 263 Query: 355 VLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLV 414 + R + E D S M+P +++E +R ++R D L+ I A + Sbjct: 264 FPDQRAKLEADPS----MIP---NTVQEIIRWQTPLAHMRRTATVDSELEGQQIKAGDKL 316 Query: 415 QVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLF 474 + + RD + F + D+ R ++ R+L FG G+ +CVG R+AEL++ + Sbjct: 317 ALWYISANRDESVFENADRIIVDRPNAR-------RHLAFGHGIHRCVGARLAELQIAVL 369 Query: 475 L 475 L Sbjct: 370 L 370 >6A7J-A nrPDB Length = 411 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 32/105 (30%), Positives = 51/105 (48%), Gaps = 10/105 (9%) Query: 380 IKETLRLH-PISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFS-SPDKFDPT 437 I+ETLR + P S L R+ D+ + D ++P + V+ A+GRD + + FD T Sbjct: 277 IEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGPTAGDFDAT 336 Query: 438 RWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 R + R++ FG G C G ++ LE + L + E F Sbjct: 337 RTPN--------RHIAFGHGPHVCPGAALSRLEAGIALPALYERF 373 >5IT1-A nrPDB Length = 399 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 32/120 (26%), Positives = 54/120 (45%), Gaps = 10/120 (8%) Query: 365 DISKMLQMVP-LLKASIKETLRLHPIS-VTLQRYPESDLVLQDYLIPAKTLVQVAIYAMG 422 D +LQ P L+ +++E LR I +R D + I V + + Sbjct: 258 DQLALLQKDPSLIGNAVEELLRYLTIGQFGAERVATQDGEIGGVRIAKGEQVVTHLLSAD 317 Query: 423 RDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 DPAF P++FD TR + +L FG+G QC+G+++A +E+ + + F Sbjct: 318 FDPAFVEDPERFDITRRPAP--------HLAFGFGAHQCIGQQLARIELQIVFGTLFRRF 369 >5EX6-C nrPDB Length = 434 Score = 42.4 bits (98), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 37/145 (25%), Positives = 61/145 (42%), Gaps = 14/145 (9%) Query: 341 MARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPES- 399 +A N+ M+ VL R E I+ + VP + ++ E +R ++V P + Sbjct: 271 LAGDDNISGMIGLGVLALLRNPE-QIAALRGDVPAAERAVDELIRY--LTVPYAPTPRTA 327 Query: 400 --DLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWG 457 D + D +I A V ++ RDPA D+ D TR ++ FG G Sbjct: 328 IEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADRLDVTREAVP--------HVAFGHG 379 Query: 458 VRQCVGRRIAELEMTLFLIHILENF 482 V C+G +A LE+ + + F Sbjct: 380 VHHCLGAALARLELRIAYTALWRRF 404 >5DE9-A nrPDB Length = 410 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 68/278 (24%), Positives = 108/278 (38%), Gaps = 48/278 (17%) Query: 220 GMLEETVN------PEAQKFIDAVYKMFHTSV--PLLNVPPELYRLFRTKTWRDHVAAWD 271 GML+E V+ P A +AV F +V L+ VP T R + W Sbjct: 126 GMLDELVDAMLRAGPPAD-LTEAVLSPFPIAVICELMGVP---------ATDRHSMHTWT 175 Query: 272 TIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTS 331 + + E+ R K E Y L L + ++T +L V Sbjct: 176 QLILSSSHGAEVSE---RAKNEMNAYFSDLIGLRS------DSAGEDVTSLLGAAVGRDE 226 Query: 332 MTLQWHLYEMARSLNVQEMLREEVLNARRQ------AEGDISKMLQMVPLLKA-SIKETL 384 +TL E + ++ E V N Q + ++++ L+ P ++ +I E L Sbjct: 227 ITLS----EAVGLAVLLQIGGEAVTNNSGQMFHLLLSRPELAERLRSEPEIRPRAIDELL 282 Query: 385 RL--HPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSK 442 R H +V L R D+ ++ I A V V+ A RDP F PD+ D R + Sbjct: 283 RWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFERSPNP 342 Query: 443 DKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILE 480 ++ FG+G C G +A LE L + +L+ Sbjct: 343 --------HVSFGFGPHYCPGGMLARLESELLVDAVLD 372 >2RCM-A nrPDB Length = 495 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 37/159 (23%), Positives = 67/159 (42%), Gaps = 22/159 (13%) Query: 347 VQEMLREEVLNARRQAEGDIS-KMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQD 405 V L EE+ + + G+++ ++ + L K+ + E LR P + DLV++ Sbjct: 317 VHNRLAEEIRSVIKSNGGELTMGAIEKMELTKSVVYECLRFEPPVTAQYGRAKKDLVIES 376 Query: 406 YLIPAKTLVQVAIYA----MGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGW----- 456 + K +Y RDP F D+F P R++ ++ + + L W Sbjct: 377 HDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEEGEKLLRHVL---WSNGPE 433 Query: 457 ------GVRQCVGRRIAELEMTLFLIHIL---ENFKVEM 486 G +QC G+ L LF+I I ++F +E+ Sbjct: 434 TETPTVGNKQCAGKDFVVLVARLFVIEIFRRYDSFDIEV 472 >5HIW-A nrPDB Length = 398 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 30/120 (25%), Positives = 57/120 (47%), Gaps = 14/120 (11%) Query: 366 ISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDP 425 ++++ Q LL +I+E+ R + + R+ E + + + A T++ +++ A D Sbjct: 251 MNQLRQQPSLLPQAIEESTRWCSSAAGIVRFVEREATIGGETLAAGTILYLSLIARHYDE 310 Query: 426 AFFSSPDKFDPTRWLSKDKDLIHFRNLG---FGWGVRQCVGRRIAELEMTLFLIHILENF 482 + P+ FD IH R +G FG G+ CVG +A +E + + +LE F Sbjct: 311 EIYPRPETFD-----------IHRRPVGMLNFGGGLHYCVGAPLARMEARVGVSLLLERF 359 >4WPZ-A nrPDB Length = 397 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 28/108 (25%), Positives = 52/108 (48%), Gaps = 12/108 (11%) Query: 379 SIKETLRLHPISVT---LQRYPESDLVLQD-YLIPAKTLVQVAIYAMGRDPAFFSSPDKF 434 ++ E LR P++ T + R +++ L ++PA +V A+ RDP F ++ Sbjct: 268 AVDELLRFVPLTTTGGIIPRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERL 327 Query: 435 DPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 + TR + +L FG G+ C+G ++A +E+ L IL+ Sbjct: 328 NVTRE--------NNPHLAFGAGIHHCLGAQLARIELQEALGAILDRM 367 >3RWL-A nrPDB Length = 426 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 42/220 (19%), Positives = 87/220 (39%), Gaps = 28/220 (12%) Query: 267 VAAWD---TIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEML 323 V +WD T + Y ++ + + K + +L + M E+ N+ ++ Sbjct: 204 VESWDQRKTELLECAAYFQVLWNERVNKDPGNDLISMLAHSPATRNMTPEEYLGNVLLLI 263 Query: 324 AGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKET 383 GG +TT ++ + + ++ + +K+ L++ + E Sbjct: 264 VGGNDTTRNSMTGGVLALHKNPD------------------QFAKLKANPALVETMVPEI 305 Query: 384 LRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKD 443 +R ++R +D L I V + Y+ RD P++F R + Sbjct: 306 IRWQTPLAHMRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDRPRPR- 364 Query: 444 KDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 ++L FG+G+ +CVG R+AE+++ + IL F Sbjct: 365 ------QHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFS 398 >2NZA-A nrPDB Length = 413 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 40/139 (28%), Positives = 62/139 (44%), Gaps = 15/139 (10%) Query: 346 NVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLR--LHPISVTLQRYPESDLVL 403 NV +ML +L RR+ +++M + ++ E LR H SV L R D+ + Sbjct: 252 NVGQML--YLLLTRREL---MARMRERPGARGTALDELLRWISHRTSVGLARIALEDVEV 306 Query: 404 QDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVG 463 I A V V+ A RDP F PD+ D L +D + +L +G G C G Sbjct: 307 HGTRIAAGEPVYVSYLAANRDPDVFPDPDRID----LDRDPNP----HLAYGNGHHFCTG 358 Query: 464 RRIAELEMTLFLIHILENF 482 +A ++ L + +LE Sbjct: 359 AVLARMQTELLVDTLLERL 377 >5L94-A nrPDB Length = 410 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 58/254 (22%), Positives = 102/254 (40%), Gaps = 48/254 (18%) Query: 247 LLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNY--------- 297 +L VP E R F K W D + A + N+ E ++ + ++ E Y Sbjct: 150 ILGVPIEDQRQF--KDWSDIIVAGPS-NNERETLEKLQQEKMKANDELETYFYRIIEEKR 206 Query: 298 --PG--ILYCLLKSE---KMLLED--VKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQ 348 PG I+ LL+++ K L ++ V +I ++AG TT++ M + + Sbjct: 207 TRPGDDIISVLLQAKEEGKQLTDEEIVGFSILLLIAGNETTTNLISNTIYCLMEDKASFE 266 Query: 349 EMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLI 408 + RE+ LL + I+E LR L R + D+ L + Sbjct: 267 RLKREK-------------------ELLPSGIEEVLRYRSPVQALHRIVKEDVTLAGKKL 307 Query: 409 PAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAE 468 A V + + RD +F P+ F R K +H + FG G+ C+G +A Sbjct: 308 KAGEHVVPWMGSAHRDAEYFEDPEVFKIDR-----KPNVH---MAFGRGIHFCLGAPLAR 359 Query: 469 LEMTLFLIHILENF 482 +E + L +++ + Sbjct: 360 IEAKIMLAELIDRY 373 >5Y1I-A nrPDB Length = 403 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 28/106 (26%), Positives = 52/106 (49%), Gaps = 9/106 (8%) Query: 379 SIKETLRLHPISV-TLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFF-SSPDKFDP 436 +++E LR I+ T++R D+ + +I A + + A DP + +PD+ D Sbjct: 275 TVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDI 334 Query: 437 TRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 R ++ R+L FG+GV QC+G +A +E+ + +L Sbjct: 335 HRANAR-------RHLAFGYGVHQCLGATLARVELQIVYSTLLRRI 373 >5EX8-A nrPDB Length = 424 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 29/91 (31%), Positives = 46/91 (50%), Gaps = 10/91 (10%) Query: 380 IKETLR-LHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTR 438 + ET+R L T R D+ + + L+ A V ++ A R P + S+ D+FD TR Sbjct: 302 LDETMRYLTTDEKTHPRVATQDVRIGNQLVKAGDTVTCSLLAANR-PNYPSAEDEFDITR 360 Query: 439 WLSKDKDLIHFRNLGFGWGVRQCVGRRIAEL 469 ++ +L FG G+ C+GR +AEL Sbjct: 361 EKAE--------HLAFGHGIHHCLGRAMAEL 383 >4TRI-A nrPDB Length = 407 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 50/216 (23%), Positives = 84/216 (38%), Gaps = 31/216 (14%) Query: 268 AAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSE----KMLLEDVKANITEML 323 AA + + YTE F +D+ K + L+ SE +M +++ +L Sbjct: 173 AAIQKLMDTFAAYTE-FTKDVITKRRAEPTDDLFSVLVNSEVEGQRMSDDEIVFETLLIL 231 Query: 324 AGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKET 383 GG TT TL E++L R Q + ++ V LL +I+E Sbjct: 232 IGGDETTRHTLSGGT--------------EQLLRHRDQWDALVAD----VDLLPGAIEEM 273 Query: 384 LRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKD 443 LR + R +D V + A + + + D + F PD F R + Sbjct: 274 LRWTSPVKNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDRNPNS- 332 Query: 444 KDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHIL 479 ++ FG+G C+G ++A LE+ L +L Sbjct: 333 -------HVAFGFGTHFCLGNQLARLELRLMTERVL 361 >2XKR-A nrPDB Length = 398 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 42/159 (26%), Positives = 65/159 (40%), Gaps = 28/159 (17%) Query: 322 MLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVP-LLKASI 380 +L GG TT TL S +++LR D +LQ P LL +I Sbjct: 227 ILIGGDETTRHTL---------SGGTEQLLRNR----------DQWDLLQRDPSLLPGAI 267 Query: 381 KETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWL 440 +E LR + R +D + A + + + D A F P+KFD R Sbjct: 268 EEMLRWTAPVKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQRNP 327 Query: 441 SKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHIL 479 + +L FG+G C+G ++A LE++L +L Sbjct: 328 NS--------HLAFGFGTHFCLGNQLARLELSLMTERVL 358 >5GWE-A nrPDB Length = 405 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 27/107 (25%), Positives = 52/107 (48%), Gaps = 7/107 (6%) Query: 369 MLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFF 428 +L+ L+ A++ E LR V +R D + I V + + + RD A F Sbjct: 268 ILENPKLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARF 327 Query: 429 SSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFL 475 + ++FD +R +++ +L FG+G+ C+G +A+L+ + L Sbjct: 328 ENGEEFDISRANARE-------HLSFGFGIHYCLGNMLAKLQAKICL 367 >5XJN-A nrPDB Length = 455 Score = 39.7 bits (91), Expect = 0.004, Method: Compositional matrix adjust. Identities = 27/107 (25%), Positives = 52/107 (48%), Gaps = 7/107 (6%) Query: 369 MLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFF 428 +L+ L+ A++ E LR V +R D + I V + + + RD A F Sbjct: 318 ILENPKLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARF 377 Query: 429 SSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFL 475 + ++FD +R +++ +L FG+G+ C+G +A+L+ + L Sbjct: 378 ENGEEFDISRANARE-------HLSFGFGIHYCLGNMLAKLQAKICL 417 >6DCD-A nrPDB Length = 424 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 41/167 (24%), Positives = 64/167 (38%), Gaps = 25/167 (14%) Query: 314 DVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMV 373 DV + T + A G TT+ L + + ++Q LRE Sbjct: 241 DVVRSATFLFAAGQETTAKLLTAAMRVLGDRPDIQRRLREN------------------R 282 Query: 374 PLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDK 433 L+ I+E+LR+ + R + I A T+V V A RDP F P + Sbjct: 283 SLIPNFIEESLRMDSPVKSDSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHE 342 Query: 434 FDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILE 480 F R ++ ++ F GV C G +A +E + L IL+ Sbjct: 343 FRLDRPNVRE-------HMAFARGVHSCPGGPLARVEGRVSLERILD 382 >5YSW-A nrPDB Length = 441 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 31/96 (32%), Positives = 48/96 (50%), Gaps = 14/96 (14%) Query: 379 SIKETLR-LHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPT 437 +++E LR L ++ + R+ + DL IPA + V V++ A RD Sbjct: 313 AVEELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDA-----------R 361 Query: 438 RWLSKDKDLIHFR--NLGFGWGVRQCVGRRIAELEM 471 W D DL R +L FG GV QC+G+++A +EM Sbjct: 362 HWPDPDLDLTRPRGPHLAFGHGVHQCLGQQLARMEM 397 >5YHJ-A nrPDB Length = 413 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 30/130 (23%), Positives = 54/130 (41%), Gaps = 9/130 (6%) Query: 380 IKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRW 439 ++E R +P ++D Y P TL + +Y D + ++ PD+FDP+R+ Sbjct: 276 VQEVRRFYPFFPVAAARVKTDFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSRF 335 Query: 440 LSKDKDLIHFRNLGFG---WGVRQCVGRRIAELEMTLFLIHILENFKVEMQH-IGDVDTI 495 + +F G G +G R C G + L ++E F E + + D Sbjct: 336 KDWKESPFNFIPQGGGDVDFGHR-CAGEHVT----IAILAQVIELFTKEYAYTVPPQDLS 390 Query: 496 FNLILTPDKP 505 ++ + P P Sbjct: 391 YSFVDMPSLP 400 >3DBM-A nrPDB Length = 473 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 33/158 (20%), Positives = 74/158 (46%), Gaps = 18/158 (11%) Query: 346 NVQEMLREEVLNA-RRQAEGDIS-KMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVL 403 N+ L EE+ A + +G+++ + ++ +PL K+ + E+LR+ P +S+ + Sbjct: 298 NLHTQLAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVVYESLRIEPPVPPQYGKAKSNFTI 357 Query: 404 QDY-----LIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGV 458 + + + + L +A +DP F P+++ P R++ + L+ + G Sbjct: 358 ESHDATFEVKKGEMLFGYQPFAT-KDPKVFDRPEEYVPDRFVGDGEALLKYVWWSNGPET 416 Query: 459 -------RQCVGRRIAELEMTLFLIHIL---ENFKVEM 486 +QC G+ L LF+I + ++F++E+ Sbjct: 417 ESPTVENKQCAGKDFVVLITRLFVIELFRRYDSFEIEL 454 >5HH3-A nrPDB Length = 397 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 26/78 (33%), Positives = 37/78 (47%), Gaps = 9/78 (11%) Query: 392 TLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRN 451 T R D+ + D+LI A V ++ A R F D+FD TR + + Sbjct: 288 THPRVATDDVRIGDHLIKAGDTVTCSLLAANRR-NFPRPEDRFDITR--------VRPEH 338 Query: 452 LGFGWGVRQCVGRRIAEL 469 L FG G+ C+GR +AEL Sbjct: 339 LAFGHGIHHCLGRSLAEL 356 >5D3U-A nrPDB Length = 427 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 27/117 (23%), Positives = 48/117 (41%), Gaps = 7/117 (5%) Query: 366 ISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDP 425 + + L + + E LR + + R D+ + I A + + + + RD Sbjct: 290 VERFLADQACVDNTANEVLRYNASNQFTWRVAAKDVEMGGVRIEAGQTLALFLGSANRDA 349 Query: 426 AFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 F P+ FD R S R+L FG GV C+ ++ L++ F + +L F Sbjct: 350 NMFERPNDFDLDRPNSA-------RHLSFGQGVHACLAAQLISLQLKWFYVALLNRF 399 >2ZQJ-A nrPDB Length = 417 Score = 37.4 bits (85), Expect = 0.017, Method: Compositional matrix adjust. Identities = 27/106 (25%), Positives = 45/106 (42%), Gaps = 5/106 (4%) Query: 380 IKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRW 439 ++E R +P L + D V + T V + +Y DP + PD+F P R+ Sbjct: 280 VQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFRPERF 339 Query: 440 LSKDKDLIHFRNLGFGWGVR--QCVGRRIAELEMTL---FLIHILE 480 ++++L G G + +C G I M FL+H +E Sbjct: 340 AEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIE 385 >4YT3-A nrPDB Length = 410 Score = 37.4 bits (85), Expect = 0.017, Method: Compositional matrix adjust. Identities = 49/188 (26%), Positives = 76/188 (40%), Gaps = 28/188 (14%) Query: 300 ILYCLLKSE---KMLLEDVKANITEMLAG-GVNTTSMTLQWHLYEMARSLNVQEMLREEV 355 I+ LLKSE +M +D T ++ G GV TTS L Y + Sbjct: 214 IISDLLKSEVDGEMFTDDEVVRTTMLILGAGVETTSHLLANSFYSL-------------- 259 Query: 356 LNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQ 415 L ++ ++ + L +VP +++E LR + L R + D L + V Sbjct: 260 LYDDKEVYQELHENLDLVP---QAVEEMLRFRFNLIKLDRTVKEDNDLLGVELKEGDSVV 316 Query: 416 VAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFL 475 V + A D F P + R +K ++L FG G C+G +A LE + L Sbjct: 317 VWMSAANMDEEMFEDPFTLNIHRPNNK-------KHLTFGNGPHFCLGAPLARLEAKIAL 369 Query: 476 IHILENFK 483 L+ FK Sbjct: 370 TAFLKKFK 377 >1LG9-A nrPDB Length = 398 Score = 37.4 bits (85), Expect = 0.017, Method: Compositional matrix adjust. Identities = 46/164 (28%), Positives = 63/164 (38%), Gaps = 32/164 (19%) Query: 322 MLAGGVNTTSMTLQWHLYEMARSLNVQEMLRE-EVLNARRQAEGDISKMLQMVPLLKASI 380 MLAG N + M L V MLR E ++A R E + ++ Sbjct: 234 MLAGDDNISGMI----------GLGVLAMLRHPEQIDAFRGDEQSAQR----------AV 273 Query: 381 KETLR--LHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTR 438 E +R P S T R DL L I V ++ A RDPA D+ D TR Sbjct: 274 DELIRYLTVPYSPT-PRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTR 332 Query: 439 WLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 + + H + FG GV C+G +A LE+ + F Sbjct: 333 -----EPIPH---VAFGHGVHHCLGAALARLELRTVFTELWRRF 368 >2Z36-A nrPDB Length = 413 Score = 36.6 bits (83), Expect = 0.028, Method: Compositional matrix adjust. Identities = 26/96 (27%), Positives = 44/96 (45%), Gaps = 9/96 (9%) Query: 379 SIKETLRLHPISVTL-QRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPT 437 +++E LR I+ + R D+ + I A V V++ + DPA F P D Sbjct: 281 AVEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVE 340 Query: 438 RWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTL 473 R +L FG+G QC+G+ +A +E+ + Sbjct: 341 RGARH--------HLAFGFGPHQCLGQNLARMELQI 368 >3AWQ-A nrPDB Length = 415 Score = 36.6 bits (83), Expect = 0.029, Method: Compositional matrix adjust. Identities = 39/191 (20%), Positives = 74/191 (38%), Gaps = 22/191 (11%) Query: 309 KMLLEDVKANITEMLAGGVNTTSMTLQWH-------LYEMARSLNVQEMLREEVL----- 356 K ++E ++A + G T + + WH L ++ + +LR V Sbjct: 194 KRIIEGIRAG---SIGSGSGTAAYAIAWHRDRHDDLLSPHVAAVELVNVLRPTVAIAVYI 250 Query: 357 ----NARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKT 412 +A + G + ++Q + ++E R +P + D + P Sbjct: 251 TFVAHALQTCSGIRAALVQQPDYAELFVQEVRRFYPFFPAVVARASQDFEWEGMAFPEGR 310 Query: 413 LVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFG--WGVRQCVGRRIAELE 470 V + +Y D A ++ P +F P R+ + D+D +F G G + +C G I L Sbjct: 311 QVVLDLYGSNHDAATWADPQEFRPERFRAWDEDSFNFIPQGGGDHYLGHRCPGEWIV-LA 369 Query: 471 MTLFLIHILEN 481 + H+L N Sbjct: 370 IMKVAAHLLVN 380 >3BUJ-A nrPDB Length = 397 Score = 35.8 bits (81), Expect = 0.042, Method: Compositional matrix adjust. Identities = 27/96 (28%), Positives = 45/96 (46%), Gaps = 8/96 (8%) Query: 375 LLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKF 434 LL +++E LR P + R + D+ L+ + +V V A RDP + PD F Sbjct: 265 LLAQAVEECLRYDPSVQSNTRQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDF 324 Query: 435 DPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELE 470 D + +D ++ FG G+R C+G +A + Sbjct: 325 D----IERDP----VPSMSFGAGMRYCLGSYLARTQ 352 >4MM0-A nrPDB Length = 399 Score = 35.4 bits (80), Expect = 0.056, Method: Compositional matrix adjust. Identities = 30/109 (27%), Positives = 47/109 (43%), Gaps = 9/109 (8%) Query: 375 LLKASIKETLRLHPIS-VTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDK 433 LL ++++E +R P L R D+ + D IPA + V + A DP F Sbjct: 268 LLPSAVEELMRYAPAGDGALFRVTLEDVTIGDTHIPANSAVLASTQAANWDPRRFD---- 323 Query: 434 FDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 DPT D H G G+ C+G +A +E+ + + +L F Sbjct: 324 -DPTGLRLDRPDNQH---TALGHGIHFCLGAALARVELQVAIGALLRRF 368 >6HQD-A nrPDB Length = 420 Score = 35.0 bits (79), Expect = 0.089, Method: Compositional matrix adjust. Identities = 38/170 (22%), Positives = 67/170 (39%), Gaps = 25/170 (14%) Query: 314 DVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMV 373 D + ++ GG +TT ++ MA L QE ++V N R Sbjct: 248 DFLGTLALLIVGGNDTTRSSMSGS--AMACHLYPQEF--DKVRNNR-------------- 289 Query: 374 PLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDK 433 LL + I E +R ++R D+ + I V + + RD P Sbjct: 290 ALLASVIPEVVRWQTPIAHMRRTALEDVEFRGKQIRKGDKVVMWYLSGNRDDEVIDRPMD 349 Query: 434 FDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 F R ++ +L FG+G+ +C+G R+AEL++ + + E + Sbjct: 350 FIADRPRAR-------HHLSFGFGIHRCLGNRLAELQLKILWEEMCERYS 392 >4PWV-A nrPDB Length = 446 Score = 34.7 bits (78), Expect = 0.093, Method: Compositional matrix adjust. Identities = 30/126 (23%), Positives = 55/126 (43%), Gaps = 9/126 (7%) Query: 376 LKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFD 435 L+++ +E LR ++ R +D+ L +I A +V + + RD F+ P FD Sbjct: 303 LESATEEVLRWATPAMHFGRRAVTDMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFD 362 Query: 436 PTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTI 495 R +K ++ FG+G C+G + E+ L+ L + + G+ I Sbjct: 363 LNRSPNK--------HITFGYGPHFCLGAYLGRAEVHA-LLDALRTYTTGFEITGEPQRI 413 Query: 496 FNLILT 501 + LT Sbjct: 414 HSNFLT 419 >6FYJ-A nrPDB Length = 421 Score = 34.7 bits (78), Expect = 0.099, Method: Compositional matrix adjust. Identities = 28/128 (21%), Positives = 49/128 (38%), Gaps = 5/128 (3%) Query: 380 IKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRW 439 ++E R +P + + D + Y TL + +Y DP + +PD F P R+ Sbjct: 284 VQEVRRFYPFFPFVVALVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRF 343 Query: 440 LSKDKDLIHFRNLGFG--WGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFN 497 + F G G + +C G + M + L ++ E + D D F+ Sbjct: 344 AKWEGSPFSFIPQGGGDYFMGHRCAGEWVTIEVMKVSLDYLTNRMDYE---VPDQDLSFS 400 Query: 498 LILTPDKP 505 + P P Sbjct: 401 MASMPSIP 408 >4XE3-A nrPDB Length = 407 Score = 34.7 bits (78), Expect = 0.12, Method: Compositional matrix adjust. Identities = 26/110 (23%), Positives = 46/110 (41%), Gaps = 10/110 (9%) Query: 375 LLKASIKETLRLHPI--SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPD 432 L+ A+++E LR P+ + + R D+ L + A V + RD F D Sbjct: 276 LVPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASANRDEEVFDHAD 335 Query: 433 KFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 + D R + ++ FG G C+G ++ LE+ L ++ F Sbjct: 336 ELDFHRERNP--------HIAFGHGAHHCIGAQLGRLELQEALSALVRRF 377 >5M0P-A nrPDB Length = 428 Score = 34.3 bits (77), Expect = 0.14, Method: Compositional matrix adjust. Identities = 23/93 (24%), Positives = 38/93 (40%), Gaps = 2/93 (2%) Query: 381 KETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWL 440 +E R +P L + D+ Q IPA + + +Y D + + P++F P R+ Sbjct: 289 QEVRRYYPFVPFLPGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRPERFE 348 Query: 441 SKDKDLIHFRNLGFG--WGVRQCVGRRIAELEM 471 + D G G W +C G I + M Sbjct: 349 TWDGSPFDLIPQGGGDYWTNHRCAGEWITVIIM 381 >2YJN-B nrPDB Length = 381 Score = 34.3 bits (77), Expect = 0.14, Method: Compositional matrix adjust. Identities = 20/60 (33%), Positives = 32/60 (53%) Query: 379 SIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTR 438 ++ E LRLHP +R +++ L +++I V V + A RDP F+ PD+ D R Sbjct: 258 TVAEVLRLHPALHLERRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVDR 317 >3OO3-A nrPDB Length = 384 Score = 33.1 bits (74), Expect = 0.29, Method: Compositional matrix adjust. Identities = 26/109 (23%), Positives = 49/109 (44%), Gaps = 14/109 (12%) Query: 375 LLKASIKETLRLHPI-SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDK 433 L+ ++ +E LR I R +D+ + I A ++ ++ A R P D+ Sbjct: 258 LIDSATEEVLRHASIVEAPAPRVALADVRMAGRDIHAGDVLTCSMLATNRAPG-----DR 312 Query: 434 FDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 FD TR + ++ FG G+ C+G +A L++ + L ++ F Sbjct: 313 FDITREKAT--------HMAFGHGIHHCIGAPLARLQLRVALPAVVGRF 353 >2X9P-A nrPDB Length = 404 Score = 33.1 bits (74), Expect = 0.29, Method: Compositional matrix adjust. Identities = 29/103 (28%), Positives = 46/103 (44%), Gaps = 11/103 (10%) Query: 375 LLKASIKETLRLHPI--SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPD 432 ++ +++E LR SV RY D+ I A LV + D F+ P+ Sbjct: 273 VMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAFTGPE 332 Query: 433 KFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEM-TLF 474 +FD R + +L FG G+ C+G +A LE+ T+F Sbjct: 333 EFDAARTPNP--------HLTFGHGIWHCIGAPLARLELRTMF 367 >6M7L-A nrPDB Length = 404 Score = 32.0 bits (71), Expect = 0.60, Method: Compositional matrix adjust. Identities = 24/89 (26%), Positives = 39/89 (43%), Gaps = 13/89 (14%) Query: 395 RYPESDLVLQDYLIPAKTLVQVAIYAMGR-DPAFFSSPDKFDPTRWLSKDKDLIHFRNLG 453 R D+ + +I V ++ A R DPA D FD TR S R++ Sbjct: 297 RTATEDVEIGGQVIKKGEAVFCSLLAANRADPAL----DGFDITRKES--------RHVA 344 Query: 454 FGWGVRQCVGRRIAELEMTLFLIHILENF 482 FG G+ C+G +A +E+ + ++ F Sbjct: 345 FGHGIHHCLGAPLARMELRIAFTTLVSRF 373 >6G5O-A nrPDB Length = 399 Score = 32.0 bits (71), Expect = 0.60, Method: Compositional matrix adjust. Identities = 32/167 (19%), Positives = 64/167 (38%), Gaps = 26/167 (15%) Query: 297 YPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVL 356 Y +L + K+ E+VK + AGG +T + + +A E LR+E Sbjct: 192 YSVLLNSEFEGRKLTKEEVKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRKEPE 251 Query: 357 NARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQV 416 R +++E +R + R D + ++ + A + + + Sbjct: 252 ITGR------------------AVEEMIRYFSPLTQMGRVVTEDTHVCEHAVKADSRISL 293 Query: 417 AIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVG 463 + RD A F +P++ R ++ ++GFG+ C+G Sbjct: 294 CWASANRDAAVFENPNEIVLDRKVNP--------HVGFGFSHHNCLG 332 >5XNT-A nrPDB Length = 411 Score = 31.6 bits (70), Expect = 0.88, Method: Compositional matrix adjust. Identities = 47/188 (25%), Positives = 75/188 (39%), Gaps = 28/188 (14%) Query: 300 ILYCLLKSE---KMLLEDVKANITEMLAG-GVNTTSMTLQWHLYEMARSLNVQEMLREEV 355 I+ LLK+E +M +D T ++ G GV TTS L Y + Sbjct: 214 IISDLLKAEVDGEMFTDDEVVRTTMLILGAGVETTSHLLANSFYSL-------------- 259 Query: 356 LNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQ 415 L ++ ++ + L +VP +++E LR + L R + D L + V Sbjct: 260 LYDDKEVYQELHENLDLVP---QAVEEMLRYRFNLIKLDRTVKEDNDLLGVELKEGENVV 316 Query: 416 VAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFL 475 V + A D F + R +K ++L FG G C+G +A LE + L Sbjct: 317 VWMSAANLDEEMFEDAFTLNIHRPNNK-------KHLTFGNGPHFCLGAPLARLEAKIAL 369 Query: 476 IHILENFK 483 L+ FK Sbjct: 370 TTFLKKFK 377 >4C9K-A nrPDB Length = 421 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 32/133 (24%), Positives = 54/133 (40%), Gaps = 17/133 (12%) Query: 376 LKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFD 435 L+ ++E R + V+ RY SD+ ++ L+ + G D P D Sbjct: 289 LQRGVEELFRRFAV-VSDARYVVSDMEFHGTMLKEGDLILLPTALHGLDDRHHDDPMTVD 347 Query: 436 PTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIH--------ILENFKVEMQ 487 +R +D+ H F G +C G +A LE+T+ L L++ V + Sbjct: 348 LSR-----RDVTHST---FAQGPHRCAGMHLARLEVTVMLQEWLARIPEFRLKDRAVPIY 399 Query: 488 HIGDVDTIFNLIL 500 H G V + N+ L Sbjct: 400 HSGIVAAVENIPL 412 >6FSH-A nrPDB Length = 398 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 19/88 (21%), Positives = 35/88 (39%), Gaps = 8/88 (9%) Query: 395 RYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGF 454 R D+++ D +I V ++ RD A D+ D TR ++ F Sbjct: 289 RTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR--------TPVPHVAF 340 Query: 455 GWGVRQCVGRRIAELEMTLFLIHILENF 482 G G+ C+G + L++ + + F Sbjct: 341 GHGIHHCLGAALTRLQLRIAYTALWRRF 368 >4TX3-A nrPDB Length = 404 Score = 30.0 bits (66), Expect = 2.3, Method: Compositional matrix adjust. Identities = 19/88 (21%), Positives = 35/88 (39%), Gaps = 8/88 (9%) Query: 395 RYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGF 454 R D+++ D +I V ++ RD A D+ D TR ++ F Sbjct: 295 RTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR--------TPVPHVAF 346 Query: 455 GWGVRQCVGRRIAELEMTLFLIHILENF 482 G G+ C+G + L++ + + F Sbjct: 347 GHGIHHCLGAALTRLQLRIAYTALWRRF 374 >4GPS-A nrPDB Length = 423 Score = 30.0 bits (66), Expect = 2.5, Method: Compositional matrix adjust. Identities = 17/37 (45%), Positives = 21/37 (56%) Query: 150 DRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRI 186 DR VLN+ V+ EA + + LNP FVSL H I Sbjct: 150 DRNVLNSLVILKEAYQRYEKTLNPEKTTFVSLRHHII 186 >3KBH-E nrPDB Length = 136 Score = 30.0 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 13/36 (36%), Positives = 19/36 (52%), Gaps = 4/36 (11%) Query: 53 SPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPI 88 SPGD+ W H + + G+ F + NFQK+ I Sbjct: 55 SPGDSSW----HIYLKSGTCPFSFSKLNNFQKFKTI 86 >5IPN-F nrPDB Length = 336 Score = 28.9 bits (63), Expect = 5.8, Method: Compositional matrix adjust. Identities = 39/134 (29%), Positives = 53/134 (39%), Gaps = 33/134 (24%) Query: 353 EEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKT 412 EEV ARR GD++ +M I+ LRL + +RY L L D LI Sbjct: 75 EEVYFARRALRGDVASRRRM-------IESNLRL--VVKIARRYGNRGLALLD-LIEEGN 124 Query: 413 LVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFG-WGVRQCVGRRIAELEM 471 L + +KFDP R FR + W +RQ + R I Sbjct: 125 L------------GLIRAVEKFDPERG---------FRFSTYATWWIRQTIERAIMNQTR 163 Query: 472 TLFL-IHILENFKV 484 T+ L IHI++ V Sbjct: 164 TIRLPIHIVKELNV 177 >4FF5-A nrPDB Length = 266 Score = 28.1 bits (61), Expect = 9.3, Method: Compositional matrix adjust. Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 1/60 (1%) Query: 234 IDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFY-QDLRRKT 292 ID YK T + NVP +Y K+ ++ A + +N A Y+ +Y D+ KT Sbjct: 100 IDKAYKSHITELQKRNVPVAVYAYVAGKSVQEMEKAAEVFYNAASPYSPSYYWLDVEDKT 159 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3MZS-A nrPDB 626 e-180 3N9Z-A nrPDB 570 e-163 4ZGX-A nrPDB 447 e-126 6M7X-A nrPDB 444 e-125 3K9V-A nrPDB 408 e-114 6DA2-A nrPDB 340 1e-93 1N6B-A nrPDB 317 7e-87 5VBU-A nrPDB 304 5e-83 5VEU-A nrPDB 304 6e-83 4WMZ-A nrPDB 294 7e-80 3MDV-A nrPDB 293 1e-79 5W0C-A nrPDB 292 3e-79 3QZ1-A nrPDB 291 6e-79 5YLW-A nrPDB 291 6e-79 4GQS-A nrPDB 289 3e-78 2NNH-A nrPDB 288 5e-78 6B82-A nrPDB 284 9e-77 5UYS-A nrPDB 283 2e-76 2WX2-A nrPDB 279 2e-75 5JLC-A nrPDB 279 3e-75 3EL3-A nrPDB 275 2e-74 3L4D-A nrPDB 271 5e-73 3E6I-A nrPDB 267 9e-72 5E0E-A nrPDB 265 2e-71 2VE3-A nrPDB 265 3e-71 4R20-A nrPDB 265 3e-71 5FSA-A nrPDB 264 5e-71 5E58-A nrPDB 263 9e-71 3DL9-A nrPDB 263 9e-71 3IBD-A nrPDB 262 3e-70 4R1Z-A nrPDB 260 1e-69 4H1N-A nrPDB 259 2e-69 2X2N-A nrPDB 256 2e-68 2PG7-A nrPDB 255 2e-68 2HI4-A nrPDB 252 2e-67 6DWN-A nrPDB 249 2e-66 3JUS-A nrPDB 238 4e-63 6AYB-A nrPDB 238 5e-63 3TBG-A nrPDB 232 2e-61 6IQ5-A nrPDB 228 6e-60 6C94-A nrPDB 227 1e-59 6CR2-A nrPDB 218 5e-57 2W0A-A nrPDB 212 3e-55 3S79-A nrPDB 205 3e-53 3EJB-B nrPDB 203 2e-52 5OFQ-A nrPDB 199 2e-51 5L94-A nrPDB 199 3e-51 4RM4-A nrPDB 199 3e-51 4Z5P-A nrPDB 198 7e-51 6F0B-A nrPDB 194 7e-50 3RWL-A nrPDB 189 2e-48 5VWS-A nrPDB 188 4e-48 3WVS-A nrPDB 187 8e-48 6B11-A nrPDB 186 1e-47 1F4U-A nrPDB 186 2e-47 3OFT-A nrPDB 185 4e-47 6A7J-A nrPDB 185 5e-47 4YZR-A nrPDB 184 8e-47 3R9C-A nrPDB 183 1e-46 5FOI-A nrPDB 183 2e-46 6GK6-A nrPDB 183 2e-46 4GGV-A nrPDB 182 3e-46 2ZBZ-A nrPDB 181 6e-46 2VZM-A nrPDB 181 8e-46 5FYF-A nrPDB 180 1e-45 2Y5N-A nrPDB 180 2e-45 4JBT-A nrPDB 179 2e-45 6A7I-A nrPDB 179 2e-45 3A50-A nrPDB 179 2e-45 5CJE-A nrPDB 179 3e-45 6HQW-A nrPDB 178 6e-45 4UBS-A nrPDB 178 7e-45 1UED-A nrPDB 177 9e-45 6GMF-A nrPDB 176 2e-44 2FR7-A nrPDB 176 2e-44 5Y1I-A nrPDB 175 5e-44 4WPZ-A nrPDB 173 1e-43 3MGX-A nrPDB 173 2e-43 6HQG-A nrPDB 171 6e-43 5XW2-A nrPDB 171 7e-43 2RFC-A nrPDB 170 1e-42 5LIE-A nrPDB 170 1e-42 3ABB-A nrPDB 170 1e-42 1UE8-A nrPDB 169 2e-42 5EX6-C nrPDB 169 3e-42 3P3Z-A nrPDB 169 3e-42 1Z8P-A nrPDB 168 5e-42 2WIO-A nrPDB 167 1e-41 1CPT-A nrPDB 166 3e-41 4DO1-A nrPDB 166 3e-41 4OQS-A nrPDB 164 1e-40 1ODO-A nrPDB 163 2e-40 3A1L-A nrPDB 161 5e-40 4OQR-A nrPDB 161 5e-40 3TYW-A nrPDB 161 6e-40 3NC3-A nrPDB 160 1e-39 5Z9I-A nrPDB 158 5e-39 3TKT-A nrPDB 158 5e-39 1EHE-A nrPDB 158 6e-39 5H1Z-A nrPDB 158 6e-39 1GWI-A nrPDB 158 7e-39 3SN5-A nrPDB 157 1e-38 5DE9-A nrPDB 155 4e-38 5NWS-A nrPDB 155 4e-38 5IT1-A nrPDB 154 7e-38 3ABA-A nrPDB 152 3e-37 5HDI-A nrPDB 149 3e-36 5HIW-A nrPDB 139 3e-33 2NZA-A nrPDB 139 3e-33 6GII-A nrPDB 139 3e-33 6G71-A nrPDB 135 4e-32 2WIY-A nrPDB 135 4e-32 5L1U-A nrPDB 134 6e-32 1WIY-A nrPDB 133 1e-31 2RCM-A nrPDB 121 8e-28 Sequences not found previously or not previously below threshold: 4KPA-A nrPDB 185 6e-47 5XJN-A nrPDB 178 6e-45 5GWE-A nrPDB 178 7e-45 5XNT-A nrPDB 178 8e-45 2Z36-A nrPDB 173 2e-43 4YT3-A nrPDB 172 4e-43 4TRI-A nrPDB 168 8e-42 4MM0-A nrPDB 164 9e-41 4TX3-A nrPDB 161 6e-40 1LG9-A nrPDB 161 8e-40 4XE3-A nrPDB 161 8e-40 4Z5Q-A nrPDB 160 1e-39 6FSH-A nrPDB 159 3e-39 4PWV-A nrPDB 158 6e-39 6HQD-A nrPDB 158 7e-39 2WM5-A nrPDB 157 1e-38 5LIV-A nrPDB 156 2e-38 6F88-A nrPDB 156 3e-38 5YSW-A nrPDB 155 3e-38 2XKR-A nrPDB 155 4e-38 5DQN-A nrPDB 154 1e-37 6DCD-A nrPDB 153 2e-37 3IVY-A nrPDB 151 8e-37 1Q5D-A nrPDB 151 9e-37 6CVC-A nrPDB 148 5e-36 6M7L-A nrPDB 147 1e-35 6G5O-A nrPDB 142 4e-34 2UUQ-A nrPDB 139 3e-33 2X9P-A nrPDB 139 3e-33 3WEC-A nrPDB 135 4e-32 4FB2-A nrPDB 134 1e-31 3OO3-A nrPDB 132 4e-31 6BLD-A nrPDB 128 8e-30 5KYO-A nrPDB 126 2e-29 5HH3-A nrPDB 121 9e-28 2IJ7-A nrPDB 120 1e-27 3BUJ-A nrPDB 119 3e-27 5D3U-A nrPDB 115 4e-26 2QBO-A nrPDB 114 6e-26 5EX8-A nrPDB 110 2e-24 3NV6-A nrPDB 109 3e-24 3DBM-A nrPDB 108 5e-24 5OMS-A nrPDB 108 5e-24 4C9K-A nrPDB 107 1e-23 6FYJ-A nrPDB 105 6e-23 2IAG-A nrPDB 103 2e-22 5M0P-A nrPDB 96 4e-20 5YHJ-A nrPDB 95 6e-20 3B98-A nrPDB 94 1e-19 2ZQJ-A nrPDB 91 1e-18 3AWQ-A nrPDB 87 1e-17 2YJN-B nrPDB 70 3e-12 4YXC-B nrPDB 33 0.34 4YXB-D nrPDB 31 1.2 2WKX-A nrPDB 31 1.2 3RFT-A nrPDB 30 2.6 1ZC1-A nrPDB 30 3.2 1EF9-A nrPDB 29 3.9 >3MZS-A nrPDB Length = 486 Score = 626 bits (1614), Expect = e-180, Method: Composition-based stats. Identities = 480/480 (100%), Positives = 480/480 (100%) Query: 41 STKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVY 100 STKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVY Sbjct: 3 STKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVY 62 Query: 101 IIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMA 160 IIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMA Sbjct: 63 IIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMA 122 Query: 161 PEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLG 220 PEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLG Sbjct: 123 PEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLG 182 Query: 221 MLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKY 280 MLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKY Sbjct: 183 MLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKY 242 Query: 281 TEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYE 340 TEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYE Sbjct: 243 TEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYE 302 Query: 341 MARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESD 400 MARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESD Sbjct: 303 MARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESD 362 Query: 401 LVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQ 460 LVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQ Sbjct: 363 LVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQ 422 Query: 461 CVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQDPPQA 520 CVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQDPPQA Sbjct: 423 CVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQDPPQA 482 >3N9Z-A nrPDB Length = 487 Score = 570 bits (1468), Expect = e-163, Method: Composition-based stats. Identities = 353/480 (73%), Positives = 418/480 (87%), Gaps = 1/480 (0%) Query: 41 STKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVY 100 ST++PRP++EIPSPGDNGWLNLYHFWRE G+ ++H H++NFQKYGPIYREKLGN+ESVY Sbjct: 1 STRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVY 60 Query: 101 IIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMA 160 +I PEDVA LFK EG PER+ IPPW+AYH+YYQ+PIGVL KKS WKKDRV LN EVMA Sbjct: 61 VIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMA 120 Query: 161 PEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLG 220 PEA KNF+PLL+ VS+DFVS+LH+RIK+ GSG + GDI +DLF FAFESITNV+FGER G Sbjct: 121 PEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQG 180 Query: 221 MLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKY 280 MLEE VNPEAQ+FIDA+Y+MFHTSVP+LN+PP+L+RLFRTKTW+DHVAAWD IF+KA+ Y Sbjct: 181 MLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIY 240 Query: 281 TEIFYQDLRRKTE-FRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLY 339 T+ FY +LR+K +Y GILY LL KM ED+KAN+TEMLAGGV+TTSMTLQWHLY Sbjct: 241 TQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLY 300 Query: 340 EMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPES 399 EMAR+L VQ+MLR EVL AR QA+GD++ MLQ+VPLLKASIKETLRLHPISVTLQRY + Sbjct: 301 EMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVN 360 Query: 400 DLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVR 459 DLVL+DY+IPAKTLVQVAIYA+GR+P FF P+ FDPTRWLSKDK++ +FRNLGFGWGVR Sbjct: 361 DLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVR 420 Query: 460 QCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQDPPQ 519 QC+GRRIAELEMT+FLI++LENF+VE+QH+ DV T FNLIL P+KPI F PFNQ+ Q Sbjct: 421 QCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQ 480 >4ZGX-A nrPDB Length = 489 Score = 447 bits (1150), Expect = e-126, Method: Composition-based stats. Identities = 177/478 (37%), Positives = 282/478 (58%), Gaps = 1/478 (0%) Query: 37 GAGISTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNL 96 A + +T P+ +P N WL L WRE+G + +H + FQ+ GPI+R LG Sbjct: 4 KAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGP 63 Query: 97 ESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNT 156 V ++ PEDV L + + +P R + PW+AY ++ GV W+ +R+ LN Sbjct: 64 RMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNP 123 Query: 157 EVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFG 216 +V++P+A++ F+P+++ V++DF L K++ Q G D++ +FH+ E+ +FG Sbjct: 124 DVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFG 183 Query: 217 ERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNK 276 ERLG++ + + + F+ A+ MF ++V L+ +P L R K W++H AWD IF Sbjct: 184 ERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQY 243 Query: 277 AEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQW 336 + + YQ+L ++Y GI+ LL ++ LE +KAN E+ AG V+TT+ L Sbjct: 244 GDNCIQKIYQEL-AFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLM 302 Query: 337 HLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRY 396 L+E+AR+ +VQ++LR+E L A K +PLL+A++KETLRL+P+ + L+R Sbjct: 303 TLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERV 362 Query: 397 PESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGW 456 SDLVLQ+Y IPA TLVQV +Y++GR+ A F P++++P RWL +F ++ FG+ Sbjct: 363 VSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGF 422 Query: 457 GVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFN 514 G+RQC+GRR+AE EM L L H+L++F VE D+ +++ IL P L FR N Sbjct: 423 GMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN 480 >6M7X-A nrPDB Length = 484 Score = 444 bits (1141), Expect = e-125, Method: Composition-based stats. Identities = 174/482 (36%), Positives = 278/482 (57%), Gaps = 1/482 (0%) Query: 34 TGEGAGISTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKL 93 + +T P+ +P N WL L WRE+G + +H + FQ+ GPI+R L Sbjct: 1 MAKKTSSVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDL 60 Query: 94 GNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVV 153 G V ++ PEDV L + + +P R + PW+AY ++ GV W+ +R+ Sbjct: 61 GGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 120 Query: 154 LNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNV 213 LN EV++P A++ F+P+++ V++DF L K++ Q G D++ +FH+ E+ Sbjct: 121 LNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 180 Query: 214 MFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTI 273 +FGERLG++ + + + F+ A+ MF ++V L+ +P L R K W++H AWD I Sbjct: 181 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCI 240 Query: 274 FNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMT 333 F + + YQ+L + + Y I+ LL + ++ + +KAN E+ AG V+TT Sbjct: 241 FQYGDNCIQKIYQEL-AFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFP 299 Query: 334 LQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTL 393 L L+E+AR+ NVQ+ LR+E L A K +PLL+A++KETLRL+P+ + L Sbjct: 300 LLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 359 Query: 394 QRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLG 453 +R SDLVLQ+Y IPA TLV+V +Y++GR+PA F P++++P RWL +F ++ Sbjct: 360 ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVP 419 Query: 454 FGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPF 513 FG+G+RQC+GRR+AE EM L L H+L++ +VE D+ +++ IL P L FR Sbjct: 420 FGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAI 479 Query: 514 NQ 515 N Sbjct: 480 NH 481 >3K9V-A nrPDB Length = 482 Score = 408 bits (1047), Expect = e-114, Method: Composition-based stats. Identities = 137/470 (29%), Positives = 240/470 (51%), Gaps = 10/470 (2%) Query: 46 RPYSEIPSPGDNGWLN--LYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIH 103 R +++P P + L L FW+ G ++ H E +KYG I+R KLG+ +SV++ Sbjct: 21 RNVTDLPGPTNWPLLGSLLEIFWK-GGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGS 79 Query: 104 PEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEA 163 P + L++ E ++P+R +I PW AY + + G++ + W++ R ++M P Sbjct: 80 PSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVE 139 Query: 164 IKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLE 223 I +N V DF+ + + ++G + D+ +L ++FESI V++ +R G+L+ Sbjct: 140 IMKLDKKINEVLADFLERMDELCDERGR---IPDLYSELNKWSFESICLVLYEKRFGLLQ 196 Query: 224 ETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEI 283 + EA FI A+ M T ++ P EL++ TK W+ H AWDTIF + + Sbjct: 197 KETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDN 256 Query: 284 FYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMAR 343 Q + + L + + + + +++ A +TE+ V TT+ +L W LY ++R Sbjct: 257 RLQ----RYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSR 312 Query: 344 SLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVL 403 + Q L +EV + + ++ L+ +P LKA +KE++RL P R + VL Sbjct: 313 NPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVL 372 Query: 404 QDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVG 463 +Y +P T++ + +G F KF P RWL K+K + F +L FG G R C+G Sbjct: 373 GEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIG 432 Query: 464 RRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPF 513 RR+AEL++ L L I++ + + V+ + IL P + + + FRP Sbjct: 433 RRLAELQLHLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRPR 482 >6DA2-A nrPDB Length = 487 Score = 340 bits (871), Expect = 1e-93, Method: Composition-based stats. Identities = 117/513 (22%), Positives = 212/513 (41%), Gaps = 65/513 (12%) Query: 27 WGHHRVGTGEGAGISTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYG 86 +G H G + GI TP P+ G + YH + +E +KYG Sbjct: 5 YGTHSHGLFKKLGIPGPTPLPFL--------GNILSYH-------KGFCMFDMECHKKYG 49 Query: 87 PIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVL-----F 141 ++ G + I P+ + + E Y + +R P+G + Sbjct: 50 KVWGFYDGQQPVLAITDPDMIKTVLVKE-----CYSV----FTNRRPFGPVGFMKSAISI 100 Query: 142 KKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKED 201 + WK+ R +L+ + + +K +P+ ++Q L+ ++ +GK V +K+ Sbjct: 101 AEDEEWKRLRSLLSPTFTSGK-LKEMVPI---IAQYGDVLVRNLRREAETGKPV-TLKDV 155 Query: 202 LFHFAFESITNVMFGERLGMLEETVNPEAQK--------FIDAVY---KMFHTSVPLLNV 250 ++ + IT+ FG + L +P + F+D + +F +P+L V Sbjct: 156 FGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEV 215 Query: 251 ------PPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCL 304 P E+ R R ++ +K+ F Q + + Sbjct: 216 LNICVFPREVTNFLRKSVKR----MKESRLEDTQKHRVDFLQLMIDSQNSKETES----- 266 Query: 305 LKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEG 364 + + ++ A + G TTS L + +YE+A +VQ+ L+EE+ Sbjct: 267 --HKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAP 324 Query: 365 DISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRD 424 + + L + ETLRL PI++ L+R + D+ + IP +V + YA+ RD Sbjct: 325 PTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRD 384 Query: 425 PAFFSSPDKFDPTRWLSKDKDLI-HFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 P +++ P+KF P R+ K+KD I + FG G R C+G R A + M L LI +L+NF Sbjct: 385 PKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 444 Query: 484 VEMQHIGDVDTIFNL--ILTPDKPIFLVFRPFN 514 + + +L +L P+KP+ L + Sbjct: 445 FKPCKETQIPLKLSLGGLLQPEKPVVLKVESRD 477 >1N6B-A nrPDB Length = 473 Score = 317 bits (812), Expect = 7e-87, Method: Composition-based stats. Identities = 103/484 (21%), Positives = 178/484 (36%), Gaps = 45/484 (9%) Query: 52 PSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAH-L 110 P P + K + + E YGP++ LG +V + E V L Sbjct: 13 PGPTPFPIIGNILQIDAKDISKSLTKFSEC---YGPVFTVYLGMKPTVVLHGYEAVKEAL 69 Query: 111 FKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRV----VLNTEVMAPEAIKN 166 + R +P K +G+ F + TWK+ R L M +I++ Sbjct: 70 VDLGEEFAGRGSVPIL----EKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGKRSIED 125 Query: 167 FIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETV 226 I ++ V L K F+ L I +V+F R +E Sbjct: 126 RI---QEEARCLVEELRKTNASPCDPTFI------LGCAPCNVICSVIFHNRFDYKDE-- 174 Query: 227 NPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIF-- 284 E K ++++ H +V LL P L D+ K Y + F Sbjct: 175 --EFLKLMESL----HENVELLGTP-WLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIM 227 Query: 285 -----YQDLRRKTEFRNYPGILYCLLKSE---KMLLEDVKANITEMLAGGVNTTSMTLQW 336 +Q L R++ ++ E + LE + ++++ G TTS TL++ Sbjct: 228 EKVKEHQKLLDVNNPRDFIDCFLIKMEQENNLEFTLESLVIAVSDLFGAGTETTSTTLRY 287 Query: 337 HLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRL-HPISVTLQR 395 L + + V ++EE+ + + +P A I E R + L Sbjct: 288 SLLLLLKHPEVAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPH 347 Query: 396 YPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRN-LGF 454 D+ ++Y IP T + ++ ++ D F +P FDP +L + + + F Sbjct: 348 AVTRDVRFRNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPF 407 Query: 455 GWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIG---DVDTIFNLILTPDKPIFLVFR 511 G R CVG +A +E+ LFL IL+NFK++ D+ + N ++ L F Sbjct: 408 SAGKRMCVGEGLARMELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPSYQLCFI 467 Query: 512 PFNQ 515 P + Sbjct: 468 PIHH 471 >5VBU-A nrPDB Length = 476 Score = 304 bits (779), Expect = 5e-83, Method: Composition-based stats. Identities = 103/458 (22%), Positives = 183/458 (39%), Gaps = 39/458 (8%) Query: 73 RIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAH-LFKFEGSYPERYDIPPWLAYHR 131 + + QK+GPIYR LG + V + + + K + R + + R Sbjct: 25 DLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSR 84 Query: 132 YYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGS 191 Y P L S WK + + + ++ + P++ ++Q+F + + Sbjct: 85 NY--PDLSLGDYSLLWKAHKKLTRSALLLGI-RDSMEPVVEQLTQEFCERM------RAQ 135 Query: 192 GKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMF-HTSVPLLNV 250 I+E+ I + FG+++ ++ + P K I V K + H S+ +++V Sbjct: 136 PGTPVAIEEEFSLLTCSIICYLTFGDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQIVDV 193 Query: 251 --------PPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILY 302 P L RL + RDH+ ++ E R G+ Sbjct: 194 IPFLRFFPNPGLRRLKQAIEKRDHIVEMQ-----LRQHKESLVAGQWRDMMDYMLQGVAQ 248 Query: 303 CLLK--SEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARR 360 ++ S ++L V ++L GG TT+ TL W + + +Q+ L+EE+ + Sbjct: 249 PSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELG 308 Query: 361 QAEGDIS---KMLQMVPLLKASIKETLRLHPI-SVTLQRYPESDLVLQDYLIPAKTLVQV 416 K +PLL A+I E LRL P+ + L + Y IP T++ Sbjct: 309 PGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIP 368 Query: 417 AIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLI 476 + D + P +F P R+L K+ R L FG G R C+G +A LE+ + L Sbjct: 369 NLQGAHLDETVWERPHEFWPDRFLEPGKN---SRALAFGCGARVCLGEPLARLELFVVLT 425 Query: 477 HILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFN 514 +L+ F + + D + +L P + L +PF Sbjct: 426 RLLQAFTL----LPSGDALPSLQPLPHCSVILKMQPFQ 459 >5VEU-A nrPDB Length = 480 Score = 304 bits (778), Expect = 6e-83, Method: Composition-based stats. Identities = 108/508 (21%), Positives = 199/508 (39%), Gaps = 64/508 (12%) Query: 27 WGHHRVGTGEGAGISTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYG 86 +G G + GI TP P G + Y +G + E ++KYG Sbjct: 4 YGTRTHGLFKRLGIPGPTPLPLL--------GNVLSY----RQGLWKF---DTECYKKYG 48 Query: 87 PIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVL-----F 141 ++ G L + I P+ + + E Y + +R P+G + Sbjct: 49 KMWGTYEGQLPVLAITDPDVIRTVLVKE-----CYSV----FTNRRSLGPVGFMKSAISL 99 Query: 142 KKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKED 201 + WK+ R +L+ + + +K P+ ++Q L+ ++ GK V +K+ Sbjct: 100 AEDEEWKRIRSLLSPTFTSGK-LKEMFPI---IAQYGDVLVRNLRREAEKGKPV-TLKDI 154 Query: 202 LFHFAFESITNVMFGERLGMLEETVNPEAQK--------FIDAVYK---MFHTSVPLLN- 249 ++ + IT FG + L +P + F+D ++ +F P+ Sbjct: 155 FGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEA 214 Query: 250 -----VPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCL 304 P + R + N +K+ F Q + + Sbjct: 215 LNVSLFPKDTINFLSKSVNR----MKKSRLNDKQKHRLDFLQLMIDSQNSKETES----- 265 Query: 305 LKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEG 364 + + ++ A + G TTS L + LYE+A +VQ+ L++E+ Sbjct: 266 --HKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAP 323 Query: 365 DISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRD 424 + + L + ETLRL P+++ L+R + D+ + IP ++V + YA+ D Sbjct: 324 PTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHD 383 Query: 425 PAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKV 484 P +++ P++F P R+ K + + FG G R C+G R A + M L LI +L+NF Sbjct: 384 PKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSF 443 Query: 485 EMQHIGDVDTIF--NLILTPDKPIFLVF 510 + + +L P+KPI L Sbjct: 444 KPCKETQIPLKLDTQGLLQPEKPIVLKV 471 >4WMZ-A nrPDB Length = 539 Score = 294 bits (752), Expect = 7e-80, Method: Composition-based stats. Identities = 102/507 (20%), Positives = 193/507 (38%), Gaps = 61/507 (12%) Query: 40 ISTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYR-EKLGNLES 98 + P + IP W+ + K + E +KYG I+ LG + + Sbjct: 52 RKDRPPLVFYWIP------WVGSAVVYGMKPYE----FFEECQKKYGDIFSFVLLGRVMT 101 Query: 99 VYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEV 158 VY+ P+ H F F + + GV++ + ++ Sbjct: 102 VYL-GPK--GHEFVFNAKLADVSAEAAYAHLTTPVFGK-GVIYDCPNSRLMEQKKFVKGA 157 Query: 159 MAPEAIKNFIPLL-NPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGE 217 + EA K+++PL+ V + F + R+ ++ +G D+ + + + G+ Sbjct: 158 LTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTG--TIDVMVTQPEMTIFTASRSLLGK 215 Query: 218 RLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKA 277 + +T +D + + P N+P E YR RDH KA Sbjct: 216 EMRAKLDTDFAYLYSDLDKGFTPINFVFP--NLPLEHYR------KRDH-------AQKA 260 Query: 278 EKYTEIFYQDLRRKTEFRNYPGILYCLLKSE------KMLLEDVKANITEMLAGGVNTTS 331 T + RRK ++ L+K+ KM +++ + +L GG +T++ Sbjct: 261 ISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSA 320 Query: 332 MTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDIS-KMLQMVPLLKASIKETLRLHPIS 390 T W L +A +VQ+ L EE + + +++ +LQ +PLL +IKETLR+H Sbjct: 321 ATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPL 380 Query: 391 VTLQRYPESDLVLQD--YLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDK---- 444 +L R D+ + + Y+IPA V V+ +F + +F+ RW + Sbjct: 381 HSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYS 440 Query: 445 -------------DLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGD 491 + L FG G +C+G A ++ + + + K Sbjct: 441 VGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKT 500 Query: 492 VDTI--FNLILTPDKPIFLVFRPFNQD 516 V +++ P P +++ N + Sbjct: 501 VPPPDFTSMVTLPTGPAKIIWEKRNPE 527 >3MDV-A nrPDB Length = 456 Score = 293 bits (750), Expect = 1e-79, Method: Composition-based stats. Identities = 94/453 (20%), Positives = 179/453 (39%), Gaps = 22/453 (4%) Query: 68 EKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWL 127 E G + + ++ +KYGP+ R + + SV + PE V KF S D + Sbjct: 6 EVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVK---KFLMSTKYNKDSKMYR 62 Query: 128 AYHRYYQKPI---GVLFKKSGT-WKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLH 183 A + + + G++ + + W K R V++ + ++ + + N ++ V +L Sbjct: 63 ALQTVFGERLFGQGLVSECNYERWHKQRRVIDL-AFSRSSLVSLMETFNEKAEQLVEILE 121 Query: 184 KRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHT 243 + G+ +++ L + A + + FG ML P +Q AV M Sbjct: 122 AK----ADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQ----AVKLMLEG 173 Query: 244 SVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYC 303 N + R K R+ + + + + + L+R E IL Sbjct: 174 ITASRNTLAKFLPGKR-KQLREVRESIRFLRQVGRDWVQRRREALKRGEEVP--ADILTQ 230 Query: 304 LLKSEKMLLED--VKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQ 361 +LK+E+ +D + N G T++ L + + E++R + L+ EV Sbjct: 231 ILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGS 290 Query: 362 AEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAM 421 + L + L +KE+LRL+P + R E + ++ +P T + + Y M Sbjct: 291 KRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVM 350 Query: 422 GRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILEN 481 GR +F P F+P R+ F F G R C+G++ A++E+ + + +L+ Sbjct: 351 GRMDTYFEDPLTFNPDRF-GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR 409 Query: 482 FKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFN 514 + + L P P+ RP Sbjct: 410 LEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRG 442 >5W0C-A nrPDB Length = 477 Score = 292 bits (746), Expect = 3e-79, Method: Composition-based stats. Identities = 95/504 (18%), Positives = 183/504 (36%), Gaps = 51/504 (10%) Query: 31 RVGTGEGAGISTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYR 90 + +G G TP P G + + G + I + YGP++ Sbjct: 4 KTSSGRGKLPPGPTPLPVI--------GNIL------QIGIKDISKSLTNLSKVYGPVFT 49 Query: 91 EKLGNLESVYIIHPEDVAH-LFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKK 149 G V + E V L + R P +R G++F WK+ Sbjct: 50 LYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANR----GFGIVFSNGKKWKE 105 Query: 150 DRV----VLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHF 205 R L M +I++ + ++ V L K F+ L Sbjct: 106 IRRFSLMTLRNFGMGKRSIEDRV---QEEARCLVEELRKTKASPCDPTFI------LGCA 156 Query: 206 AFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFR---TKT 262 I +++F +R ++ +K + + + + + N + F K Sbjct: 157 PCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKL 216 Query: 263 WRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEK------MLLEDVK 316 ++ I K +++ Q+ +++ ++ EK +E ++ Sbjct: 217 LKNVAFMKSYILEKVKEH-----QESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLE 271 Query: 317 ANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLL 376 ++ G TTS TL++ L + + V ++EE+ + + +P Sbjct: 272 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYT 331 Query: 377 KASIKETLRL-HPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFD 435 A + E R + +L D+ ++YLIP T + +++ ++ D F +P+ FD Sbjct: 332 DAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFD 391 Query: 436 PTRWLSKDKDLIHFRN-LGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGD-VD 493 P +L + + + + F G R CVG +A +E+ LFL IL+NF ++ +D Sbjct: 392 PHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLD 451 Query: 494 TIFNLILTPDKPIF--LVFRPFNQ 515 T + P F L F P + Sbjct: 452 TTPVVNGFASVPPFYQLCFIPIHH 475 >3QZ1-A nrPDB Length = 496 Score = 291 bits (744), Expect = 6e-79, Method: Composition-based stats. Identities = 99/462 (21%), Positives = 177/462 (38%), Gaps = 50/462 (10%) Query: 74 IHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAH-LFKFEGSYPERYDIPPWLA-YHR 131 + + QK GP+YR +LG E V + + + + + R IP + R Sbjct: 45 LPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAGRPQIPSYKLVSQR 104 Query: 132 YYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGS 191 +G S WK + + + ++ + P ++ ++Q+F +R++ Q Sbjct: 105 CQDISLG---DYSLLWKAHKKLTRSALLLG-TRSSMEPWVDQLTQEFC----ERMRVQAG 156 Query: 192 GKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNV- 250 I+++ I + FG + L + Q D + H S+ +L++ Sbjct: 157 APVT--IQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQ---DLMKTWDHWSIQILDMV 211 Query: 251 -------PPELYRLFRTKTWRDHVAAWD-------TIFNKAEKYTEIFYQDLRRKTEFRN 296 P L+RL + RDH+ + + T+ Q + R Sbjct: 212 PFLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDYMLQGVGR-QRVEE 270 Query: 297 YPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVL 356 PG ++L V ++ ++ GG TT+ TL W + + +Q L+EE+ Sbjct: 271 GPG---------QLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELD 321 Query: 357 NARRQ---AEGDISKMLQMVPLLKASIKETLRLHPI-SVTLQRYPESDLVLQDYLIPAKT 412 K +PLL A+I E LRL P+ + L + Y IP Sbjct: 322 RELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGM 381 Query: 413 LVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMT 472 +V + D + P +F P R+L + L FG G R C+G +A LE+ Sbjct: 382 VVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANP---SALAFGCGARVCLGESLARLELF 438 Query: 473 LFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFN 514 + L +L+ F + +G + +L P + L +PF Sbjct: 439 VVLARLLQAFTLLPPPVGALP---SLQPDPYCGVNLKVQPFQ 477 >5YLW-A nrPDB Length = 495 Score = 291 bits (744), Expect = 6e-79, Method: Composition-based stats. Identities = 92/423 (21%), Positives = 175/423 (41%), Gaps = 16/423 (3%) Query: 75 HFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQ 134 H + ++YGP+ LG+L +V + PE + G I + + + Sbjct: 49 HQVFAKLSKRYGPLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDK 108 Query: 135 KPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKF 194 +G L + W+ R + ++ + ++++ L Q LL K SG+ Sbjct: 109 ISMGFL-PVASEWRDMRKICKEQMFSNQSMEASQGLRR---QKLQQLLDHVQKCSDSGRA 164 Query: 195 VGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPEL 254 V DI+E F ++ +F + + E ++ I+ V + VP + Sbjct: 165 V-DIREAAFITTLNLMSATLFSSQATEFDSKATMEFKEIIEGVATI--VGVPNFADYFPI 221 Query: 255 YRLFRTK-TWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPG---ILYCLLKSE-- 308 R F + R + + K E Y + R I+ ++++ Sbjct: 222 LRPFDPQGVKRRADVFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQANEF 281 Query: 309 KMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISK 368 K+ + ++ GG +T + +++W + E+ + + L+ E+ + + Sbjct: 282 KLKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDES 341 Query: 369 MLQMVPLLKASIKETLRLHPI-SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAF 427 + +P L+A IKE +R+HP + L R ESD + YLIP T + + YA+GRDP+ Sbjct: 342 AMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSI 401 Query: 428 FSSPDKFDPTRWLSKDKDLIHFRN--LGFGWGVRQCVGRRIAELEMTLFLIHILENFKVE 485 ++ P+ FDP R+L D L FG G R C G +A + + ++ NF + Sbjct: 402 WTDPETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNFDWK 461 Query: 486 MQH 488 ++ Sbjct: 462 LED 464 >4GQS-A nrPDB Length = 477 Score = 289 bits (738), Expect = 3e-78, Method: Composition-based stats. Identities = 96/504 (19%), Positives = 183/504 (36%), Gaps = 51/504 (10%) Query: 31 RVGTGEGAGISTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYR 90 + +G G TP P G + + + + + YGP++ Sbjct: 4 KTSSGRGKLPPGPTPLPVI--------GNIL------QIDIKDVSKSLTNLSKIYGPVFT 49 Query: 91 EKLGNLESVYIIHPEDVAH-LFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKK 149 G V + E V L + R P +R G++F WK+ Sbjct: 50 LYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANR----GFGIVFSNGKRWKE 105 Query: 150 DRV----VLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHF 205 R L M +I++ + ++ V L K F+ L Sbjct: 106 IRRFSLMTLRNFGMGKRSIEDRV---QEEARCLVEELRKTKASPCDPTFI------LGCA 156 Query: 206 AFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFR---TKT 262 I +++F +R ++ +K + + + + + N P + F K Sbjct: 157 PCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKL 216 Query: 263 WRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLL------KSEKMLLEDVK 316 ++ I K +++ Q+ R++ + + + +E++ Sbjct: 217 LKNLAFMESDILEKVKEH-----QESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLV 271 Query: 317 ANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLL 376 ++L G TTS TL++ L + + V ++EE+ + + +P Sbjct: 272 ITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYT 331 Query: 377 KASIKETLRL-HPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFD 435 A + E R I +L D+ ++YLIP T + ++ ++ D F +P+ FD Sbjct: 332 DAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFD 391 Query: 436 PTRWLSKDKDLIHFRN-LGFGWGVRQCVGRRIAELEMTLFLIHILENFKVE-MQHIGDVD 493 P +L + + + F G R CVG +A +E+ LFL IL+NF ++ + D+D Sbjct: 392 PRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLD 451 Query: 494 TIFNLILTPDKPIF--LVFRPFNQ 515 T + P F L F P + Sbjct: 452 TTPVVNGFASVPPFYQLCFIPIHH 475 >2NNH-A nrPDB Length = 476 Score = 288 bits (736), Expect = 5e-78, Method: Composition-based stats. Identities = 93/482 (19%), Positives = 172/482 (35%), Gaps = 53/482 (10%) Query: 36 EGAGISTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGN 95 +G TP P N+ + I + YGP++ G Sbjct: 8 KGKLPPGPTPLPIIG----------NMLQI----DVKDICKSFTNFSKVYGPVFTVYFGM 53 Query: 96 LESVYIIHPEDVAHLFKFEGS-YPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRV-- 152 V E V G + R + P + K +G++ WK+ R Sbjct: 54 NPIVVFHGYEAVKEALIDNGEEFSGRGNSPI----SQRITKGLGIISSNGKRWKEIRRFS 109 Query: 153 --VLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESI 210 L M +I++ + + V L K F+ L I Sbjct: 110 LTTLRNFGMGKRSIEDRV---QEEAHCLVEELRKTKASPCDPTFI------LGCAPCNVI 160 Query: 211 TNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFR---TKTWRDHV 267 +V+F +R ++ ++F + + + + N P L F K ++ Sbjct: 161 CSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVA 220 Query: 268 AAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEK------MLLEDVKANITE 321 I K +++ Q R++ ++ EK +E++ + + Sbjct: 221 LTRSYIREKVKEH-----QASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVAD 275 Query: 322 MLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIK 381 + G TTS TL++ L + + V ++EE+ + + + +P A + Sbjct: 276 LFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVH 335 Query: 382 ETLRLHP-ISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWL 440 E R + + +D ++YLIP T + + ++ D F +P+ FDP +L Sbjct: 336 EIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFL 395 Query: 441 SKDKDLIHFRN-LGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLI 499 K+ + + F G R C G +A +E+ LFL IL+NF ++ VD + NL Sbjct: 396 DKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLK-----SVDDLKNLN 450 Query: 500 LT 501 T Sbjct: 451 TT 452 >6B82-A nrPDB Length = 509 Score = 284 bits (725), Expect = 9e-77, Method: Composition-based stats. Identities = 97/495 (19%), Positives = 196/495 (39%), Gaps = 45/495 (9%) Query: 35 GEGAGISTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLG 94 G+ ++ P PS + H + +KYG +Y +G Sbjct: 9 GKKQKMNGFVPAGNRSPPSLPSLPIIGSLMSLVSDSPP--HIFFQDLQKKYGDLYSLMMG 66 Query: 95 NLESVYIIHPEDVAHLFKFEGS-YPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVV 153 + + + + + + +G + R R S TWK R + Sbjct: 67 SHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTR--DGKDIAFADYSSTWKFHRKM 124 Query: 154 LNTEV-MAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITN 212 ++ + M E + ++ + +L + D+ +L + Sbjct: 125 VHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSA------VDLGPELTRAVTNVVCA 178 Query: 213 VMFG---ERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAA 269 + F +R E++ +Q +D V K L+++ P L ++F K R Sbjct: 179 LCFNSSYKRGDAEFESMLQYSQGIVDTVAK-----DSLVDIFPWL-QIFPNKDLR----I 228 Query: 270 WDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEK-------------MLLEDVK 316 + +K + Y++ + +L LL++++ + + V Sbjct: 229 LRQCISIRDKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVL 288 Query: 317 ANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLL 376 + E+ GV TT+ TL+W + + + VQ ++EE+ + + +P L Sbjct: 289 MTVGEIFGAGVETTTTTLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYL 348 Query: 377 KASIKETLRLHPI-SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFD 435 +A+I E +R+ P+ + + D + +Y + T V + ++++ D + +P+ FD Sbjct: 349 EATICEVMRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFD 408 Query: 436 PTRWLSKDKDL---IHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEM---QHI 489 P R+L+++ D L FG GVR C+G +A++E+ LFL IL+ F +EM Q + Sbjct: 409 PGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPL 468 Query: 490 GDVDTIFNLILTPDK 504 D+ F ++L P K Sbjct: 469 PDLQGKFGVVLQPKK 483 >5UYS-A nrPDB Length = 494 Score = 283 bits (723), Expect = 2e-76, Method: Composition-based stats. Identities = 95/485 (19%), Positives = 189/485 (38%), Gaps = 58/485 (11%) Query: 42 TKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYI 101 K P+ +P G +L +H + +KYGPIY ++G +V + Sbjct: 7 AKYPKSLLSLPLVGSLPFL--------PRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIV 58 Query: 102 IHPEDVAHLFKFEG-SYPERYDIPPWLAYHRYYQKPIGVLFKKSGT-WK-KDRVVLNTEV 158 H + + +G + R P G+ F SG W+ R+ + T Sbjct: 59 GHHQLAKEVLIKKGKDFSGR---PQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFA 115 Query: 159 MAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGER 218 + + + + + Q+ +L G D+ F ++TNV+ Sbjct: 116 LFKDGDQKLEKI---ICQEISTLCDMLATHNGQSI-------DISFPVFVAVTNVISLIC 165 Query: 219 LGMLEETVNPE---AQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTW---RDHVAAWDT 272 + +PE Q + + + L+++ P L ++F KT + HV + Sbjct: 166 FNTSYKNGDPELNVIQNYNEGIIDNLS-KDSLVDLVPWL-KIFPNKTLEKLKSHVKIRND 223 Query: 273 IFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLK---------------SEKMLLEDVKA 317 + NK ++ + K + +L L++ SE + + Sbjct: 224 LLNK-------ILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILT 276 Query: 318 NITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLK 377 I ++ GV TT+ ++W L + + V++ L EE+ + + LL+ Sbjct: 277 TIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLE 336 Query: 378 ASIKETLRLHPI-SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDP 436 A+I+E LRL P+ + + D + ++ + T V + ++A+ + + PD+F P Sbjct: 337 ATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMP 396 Query: 437 TRWLSKDKD---LIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVD 493 R+L+ L FG G R C+G +A E+ L + +L+ F +E+ G + Sbjct: 397 ERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLP 456 Query: 494 TIFNL 498 ++ + Sbjct: 457 SLEGI 461 >2WX2-A nrPDB Length = 473 Score = 279 bits (714), Expect = 2e-75, Method: Composition-based stats. Identities = 74/444 (16%), Positives = 173/444 (38%), Gaps = 41/444 (9%) Query: 73 RIHFRHIENFQ---KYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAY 129 + ++ + K G ++ +G + P + + F ++ + Sbjct: 36 KNPLEFMQRCKRDLKSG-VFTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREV--YTIM 92 Query: 130 HRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQ 189 + + GV + ++++ E + +NF+P + + F++ + Sbjct: 93 TPVFGE--GVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMA------ENW 144 Query: 190 GSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLN 249 + V ++ ED + +FGE L A+ F + KM + +P Sbjct: 145 KEDEGVINLLEDCGAMIINTACQCLFGEDL-----RKRLNARHFAQLLSKMESSLIPAAV 199 Query: 250 VPPELYRLFRTKT--WRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKS 307 P L RL ++ R+ A I + I ++ ++ N +L LLK+ Sbjct: 200 FMPWLLRLPLPQSARCREARAELQKILGEI-----IVAREKEEASKDNNTSDLLGGLLKA 254 Query: 308 -----EKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQ--EMLREEVLNARR 360 +M L +V I + G +T+++T W + + N + + L +E+ Sbjct: 255 VYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDE--F 312 Query: 361 QAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYA 420 A+ + ++ +P + ++E++R P + + R ++++ + Y++P ++ + Sbjct: 313 PAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLL 372 Query: 421 MGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILE 480 D F +P +DP R + + +GFG GV +C+G++ A L++ L Sbjct: 373 SHHDEEAFPNPRLWDPER-----DEKVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFR 427 Query: 481 NFKVEMQHIGDVDT-IFNLILTPD 503 + ++ D +++ P Sbjct: 428 EYDFQLLRDEVPDPDYHTMVVGPT 451 >5JLC-A nrPDB Length = 515 Score = 279 bits (712), Expect = 3e-75, Method: Composition-based stats. Identities = 102/513 (19%), Positives = 194/513 (37%), Gaps = 71/513 (13%) Query: 40 ISTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYR-EKLGNLES 98 + P + IP W+ + K + + +KYG I+ LG + + Sbjct: 34 RKDRPPLVFYWIP------WVGSAIPYGTKPYE----FFEDCQKKYGDIFSFMLLGRIMT 83 Query: 99 VYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPI---GVLFKKSGTWKKDRVVLN 155 VY+ P+ H F F D+ AY + P+ GV++ ++ Sbjct: 84 VYL-GPK--GHEFIFNAKLA---DVSAEAAYS-HLTTPVFGKGVIYDCPNHRLMEQKKFV 136 Query: 156 TEVMAPEAIKNFIPLL-NPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVM 214 + EA ++PL+ + + F + + +I + SG + D+ + + + Sbjct: 137 KGALTKEAFVRYVPLIAEEIYKYFRNSKNFKINENNSG--IVDVMVSQPEMTIFTASRSL 194 Query: 215 FGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIF 274 G+ + +T +D + + P N+P E YR RDH Sbjct: 195 LGKEMRDKLDTDFAYLYSDLDKGFTPINFVFP--NLPLEHYR------KRDH-------A 239 Query: 275 NKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKS------EKMLLEDVKANITEMLAGGVN 328 +A T + RR+ ++ L+K+ KM +++ + +L GG + Sbjct: 240 QQAISGTYMSLIKERREKNDIQNRDLIDELMKNSTYKDGTKMTDQEIANLLIGVLMGGQH 299 Query: 329 TTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDIS-KMLQMVPLLKASIKETLRLH 387 T++ T W L +A +VQE L +E + +++ LQ +PLL IKETLRLH Sbjct: 300 TSAATSAWCLLHLAERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLH 359 Query: 388 PISVTLQRYPESDLVLQD--YLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDK- 444 +L R D+ + + Y++P V V+ FF P++F+ RW Sbjct: 360 HPLHSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAAS 419 Query: 445 -----------------DLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILE----NFK 483 + L FG G +C+G A ++ + + + + Sbjct: 420 SSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYP 479 Query: 484 VEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQD 516 E + + D +++ P P + + + + Sbjct: 480 TEGETVPPSD-FTSMVTLPTAPAKIYWEKRHPE 511 >3EL3-A nrPDB Length = 467 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 95/478 (19%), Positives = 172/478 (35%), Gaps = 44/478 (9%) Query: 47 PYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPED 106 P P G L H WR R + + +G + R KLG +VY + + Sbjct: 19 PELREPPVAGGGVPLLGHGWR---LARDPLAFMSQLRDHGDVVRIKLGPK-TVYAVTNPE 74 Query: 107 VAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKN 166 + Y P W + K GV ++ R + P + Sbjct: 75 LTGALALNPDY--HIAGPLWESLEGLLGKE-GVATANGPLHRRQRRTIQ-----PAFRLD 126 Query: 167 FIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETV 226 IP P+ ++ L +R + D + F A + + + + Sbjct: 127 AIPAYGPIMEEEAHALTERWQPGK----TVDATSESFRVAVRVAARCL------LRGQYM 176 Query: 227 NPEAQKFIDAVYKMFHTSVPLLNVPP-ELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFY 285 + A++ A+ +F + VP LYRL R FN A + Sbjct: 177 DERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRR---------FNDALADLHLLV 227 Query: 286 QDL--RRKTEFRNYPGILYCLLKS-----EKMLLEDVKANITEMLAGGVNTTSMTLQWHL 338 ++ R+ + +L LL++ + + +++ + +L G T + T+ W L Sbjct: 228 DEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLL 287 Query: 339 YEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPE 398 +A + +R+EV + ++ + I E +RL P L R Sbjct: 288 QALADHPEHADRIRDEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAV 346 Query: 399 SDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRW-LSKDKDLIHFRNLGFGWG 457 ++ L Y IPA + + YA+ RDP + +FDP RW + ++ + F G Sbjct: 347 AESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAG 406 Query: 458 VRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQ 515 R+C + ++TL + ++ E Q G D + I +P L+ RP + Sbjct: 407 KRKCPSDHFSMAQLTLITAALATKYRFE-QVAGSNDAVRVGITL--RPHDLLVRPVAR 461 >3L4D-A nrPDB Length = 453 Score = 271 bits (692), Expect = 5e-73, Method: Composition-based stats. Identities = 76/442 (17%), Positives = 165/442 (37%), Gaps = 38/442 (8%) Query: 73 RIHFRHI-ENFQKYGPIYREKL-GNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYH 130 + + + +KYG I+ + GN +V + R + Sbjct: 23 KDPLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQHSKFFTPRNEILSPR---EVYSFMV 79 Query: 131 RYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQG 190 + + GV + ++++ E + +NF P + + F+ Sbjct: 80 PVFGE--GVAYAAPYPRMREQLNFLAEELTVAKFQNFAPSIQHEVRKFMKA------NWN 131 Query: 191 SGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNV 250 + +I +D + +FGE L +A++F + KM +P Sbjct: 132 KDEGEINILDDCSAMIINTACQCLFGEDL-----RKRLDARQFAQLLAKMESCLIPAAVF 186 Query: 251 PPELYRLFRTKT--WRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKS- 307 P + +L ++ RD A I ++ I ++ + N +L LL + Sbjct: 187 LPWILKLPLPQSYRCRDARAELQDILSEI-----IIAREKEEAQKDTNTSDLLAGLLGAV 241 Query: 308 ----EKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMA--RSLNVQEMLREEVLNARRQ 361 +M +V I + G +T+++T W L + R+ L +E+ Sbjct: 242 YRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEIDE--FP 299 Query: 362 AEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAM 421 A+ + +++ +P + +E++R P V L R + + Y++P ++ + Sbjct: 300 AQLNYDNVMEEMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDIIACSPLLS 359 Query: 422 GRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILEN 481 +D F +P +++P R + L+ GFG GV +C+G + L++ L +L + Sbjct: 360 HQDEEAFPNPREWNPER----NMKLVDGAFCGFGAGVHKCIGEKFGLLQVKTVLATVLRD 415 Query: 482 FKVEMQHIGDVDTIFNLILTPD 503 + E+ +++ P Sbjct: 416 YDFELLGPLPEPNYHTMVVGPT 437 >3E6I-A nrPDB Length = 476 Score = 267 bits (682), Expect = 9e-72, Method: Composition-based stats. Identities = 83/437 (18%), Positives = 165/437 (37%), Gaps = 30/437 (6%) Query: 71 SQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAH-LFKFEGSYPERYDIPPWLAY 129 + I Q++GP++ +G+ V + + V L ++ + R D+P + A+ Sbjct: 29 LKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAH 88 Query: 130 HRYYQKPIGVLFKKSGTWKKDRV----VLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKR 185 G++F TWK R L M + ++ I Q L + Sbjct: 89 RDR-----GIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRI-------QREAHFLLEA 136 Query: 186 IKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSV 245 +++ F + I +++F + +E F + + + + Sbjct: 137 LRKTQGQPFDPTFL--IGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWL 194 Query: 246 PLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLL 305 L N P + + + + + +Q L R+ L + Sbjct: 195 QLYNNFPSFLHYLPGSHRK-VIKNVAEVKEYVSERVKEHHQSLDPNCP-RDLTDCLLVEM 252 Query: 306 KSEKM------LLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNAR 359 + EK ++ + + ++ G TTS TL++ L + + ++E L EE+ Sbjct: 253 EKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI 312 Query: 360 RQAEGDISKMLQMVPLLKASIKETLRLHPISVT-LQRYPESDLVLQDYLIPAKTLVQVAI 418 + K Q +P + A + E R + + L D + + YLIP T+V + Sbjct: 313 GPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTL 372 Query: 419 YAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNL-GFGWGVRQCVGRRIAELEMTLFLIH 477 ++ D F P+KF P +L+++ + F G R C G +A +E+ L L Sbjct: 373 DSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCA 432 Query: 478 ILENFKVEMQHIG-DVD 493 IL++F ++ D+D Sbjct: 433 ILQHFNLKPLVDPKDID 449 >5E0E-A nrPDB Length = 463 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 78/428 (18%), Positives = 146/428 (34%), Gaps = 35/428 (8%) Query: 83 QKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGS-YPERYDIPPWLAYHRYYQKPIGVLF 141 +KYG ++ LG V + E + + + R I A + GV+F Sbjct: 32 EKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI----AVVEPIFRGYGVVF 87 Query: 142 KKSGTWKKDRV----VLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGD 197 WK R + M +++ I ++ V K F+ Sbjct: 88 ANGERWKALRRFSLVTMRDFGMGKRSVEERI---QEEARCLVEEFRKSQGAPLDPTFL-- 142 Query: 198 IKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRL 257 I +++FGER + F + + S + + + Sbjct: 143 ----FQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFSGFLKY 198 Query: 258 FRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLL---------KSE 308 F + + Y + R + + + L + Sbjct: 199 FPGTHRQ-----ISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSNQHT 253 Query: 309 KMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISK 368 + +++ ++ + G T+S TL++ M + +V E +++E+ + Sbjct: 254 EFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLE 313 Query: 369 MLQMVPLLKASIKETLRLHP-ISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAF 427 +P +A I E R I + + D + + YL+P T V + + DP + Sbjct: 314 DRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 373 Query: 428 FSSPDKFDPTRWLSKDKDLIHF-RNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEM 486 F PD F+P +L + L + F G R C+G IA E+ LF IL+NF + Sbjct: 374 FEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSLSS 433 Query: 487 QHIG-DVD 493 D+D Sbjct: 434 PVAPKDID 441 >2VE3-A nrPDB Length = 444 Score = 265 bits (677), Expect = 3e-71, Method: Composition-based stats. Identities = 94/483 (19%), Positives = 186/483 (38%), Gaps = 62/483 (12%) Query: 44 TPRPYSEIPSPGDN---GWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVY 100 +P + +P P + WL + G + Q++GPI++ +L ++ Sbjct: 4 SPTNLNSLPIPPGDFGLPWLGETLNFLNDG-----DFGKKRQQQFGPIFKTRLFGKNVIF 58 Query: 101 IIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMA 160 I LF E + W R P L + G + R + + Sbjct: 59 ISGALANRFLFTKEQETFQ----ATWPLSTRILLGP-NALATQMGEIHRSRRKILYQAFL 113 Query: 161 PEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLG 220 P + +++P ++ + Q + ++Q G V + L F+ + GE++ Sbjct: 114 PRTLDSYLPKMDGIVQGY-------LEQWGKANEVIWYPQ-LRRMTFDVAATLFMGEKV- 164 Query: 221 MLEETVNPEAQKFIDA-VYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEK 279 + NP+ + + + +F +PL N T+F K+++ Sbjct: 165 ----SQNPQLFPWFETYIQGLFSLPIPLPN----------------------TLFGKSQR 198 Query: 280 YTEIFYQDLR-----RKTEFRNYPGILYCLL-----KSEKMLLEDVKANITEMLAGGVNT 329 + +L R+ + + L LL ++ + L ++K I +L G T Sbjct: 199 ARALLLAELEKIIKARQQQPPSEEDALGILLAARDDNNQPLSLPELKDQILLLLFAGHET 258 Query: 330 TSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPI 389 + L + + +++E +R+E N + ++ ++ L+ +P L ++E LRL P Sbjct: 259 LTSALSSFCLLLGQHSDIRERVRQEQ-NKLQLSQELTAETLKKMPYLDQVLQEVLRLIPP 317 Query: 390 SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWL--SKDKDLI 447 R D Q + P LV I DP + P+KFDP R+ Sbjct: 318 VGGGFRELIQDCQFQGFHFPKGWLVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNP 377 Query: 448 HFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIF 507 F ++ FG G+R+C+G+ A LEM LF +++ F + +++ + P + Sbjct: 378 PFAHVPFGGGLRECLGKEFARLEMKLFATRLIQQFDWTLLPGQNLELVVTPSPRPKDNLR 437 Query: 508 LVF 510 + Sbjct: 438 VKL 440 >4R20-A nrPDB Length = 486 Score = 265 bits (677), Expect = 3e-71, Method: Composition-based stats. Identities = 87/447 (19%), Positives = 164/447 (36%), Gaps = 34/447 (7%) Query: 75 HFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAH-LFKFEGSYPERYDIPPWLAYHRYY 133 H + +YGP++ G ++ + V L + + R + + Sbjct: 42 HLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQ-- 99 Query: 134 QKPIGVLFKKSGTWKKDRVVL-NTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSG 192 S WK R ++ ++ + E ++ + L Q G Sbjct: 100 GGKDIAFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEEL-----QACRG 154 Query: 193 KFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVP--LLNV 250 + D+ L I ++F + +PE Q I + T L+++ Sbjct: 155 Q-SSDLSVVLMRAVTNVICRLVFSS----SYQPSDPELQTVIQYNDGIVQTIARGGLVDI 209 Query: 251 PPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLL----- 305 P L R+F K + + + + + + + + T +L LL Sbjct: 210 FPWL-RIFPNKDLKRL---KECVSIRDQLLYKKLLEHKKSLTPGE-PRDLLDALLIGQQR 264 Query: 306 ---KSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQA 362 ++ + + V E GV TTS TL W + + +QE ++ E+ Sbjct: 265 GSGGADDITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVD 324 Query: 363 EGDISKMLQMVPLLKASIKETLRLHPI-SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAM 421 +PLL A + E +R+ P+ + + D L + +P T V V ++A+ Sbjct: 325 RPPCLSDRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAI 384 Query: 422 GRDPAFFSSPDKFDPTRWLSKDKDLI-HFRNLGFGWGVRQCVGRRIAELEMTLFLIHILE 480 DP + P++F+P R+L L FG G R CVG +A +E+ LF+ L+ Sbjct: 385 HHDPKHWDQPEQFNPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQ 444 Query: 481 NFKVEMQ---HIGDVDTIFNLILTPDK 504 F + D+ F ++L P++ Sbjct: 445 RFSFSCPSEASLPDLQGRFGVVLQPER 471 >5FSA-A nrPDB Length = 490 Score = 264 bits (675), Expect = 5e-71, Method: Composition-based stats. Identities = 88/489 (17%), Positives = 190/489 (38%), Gaps = 60/489 (12%) Query: 58 GWLNLYHFWREKGSQRIHFRHIENFQKYGPIYR-EKLGNLESVYIIHPEDVAHLFKFEGS 116 W + ++ + QKYG ++ LG + +VY+ P+ H F F Sbjct: 14 PWFGSAASYGQQPYE----FFESCRQKYGDVFSFMLLGKIMTVYL-GPK--GHEFVFNAK 66 Query: 117 YPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLL-NPVS 175 + + GV++ + ++ + ++ K ++P + + Sbjct: 67 LSDVSAEEAYKHLTTPVFG-TGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEIL 125 Query: 176 QDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFID 235 FV+ ++K++ G V ++ + + + +FG+ + + + + +D Sbjct: 126 NYFVTDESFKLKEKTHG--VANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLD 183 Query: 236 AVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFR 295 + + P L +P R K Y + R Sbjct: 184 KGFTPINFVFPNLPLPHYWRRDAAQKKIS-------------ATYMKEIKLRRERGDIDP 230 Query: 296 NYPGILYCLLKSE-----KMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEM 350 N I L+ S KM +++ + +L GG +T++ T W L + ++Q++ Sbjct: 231 NRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDV 290 Query: 351 LREEVLNARRQAEGDISKM----LQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQ-- 404 + +EV+ ++ GD++ + LQ +P + +IKETLR+H ++ R + L + Sbjct: 291 IYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPET 350 Query: 405 DYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWL---------------------SKD 443 +Y++P V V+ +F +P+ FDPTRW K Sbjct: 351 NYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKV 410 Query: 444 KDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK--VEMQHIGDVDTIFNLILT 501 + L FG G +C+G + A +++ L + N + ++ + D D ++++ Sbjct: 411 SKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPD-YSSMVVL 469 Query: 502 PDKPIFLVF 510 P +P +++ Sbjct: 470 PTEPAEIIW 478 >5E58-A nrPDB Length = 493 Score = 263 bits (673), Expect = 9e-71, Method: Composition-based stats. Identities = 81/433 (18%), Positives = 145/433 (33%), Gaps = 35/433 (8%) Query: 78 HIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGS-YPERYDIPPWLAYHRYYQKP 136 + +KYG ++ LG V + E + + + R I A + Sbjct: 55 FMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI----AVIKPVIGD 110 Query: 137 IGVLFKKSGTWKKDRV----VLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSG 192 G++F WK R + M ++++ I +Q V L K Sbjct: 111 YGMIFSNGERWKVLRRFSLATMRDFGMGKRSVEDRI---QEEAQCLVEELQKSQGAPLDP 167 Query: 193 KFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPP 252 F+ I +++FGER + F M S + + Sbjct: 168 TFL------FQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFS 221 Query: 253 ELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLL------- 305 + F + + Y + R + N + L Sbjct: 222 GFMKYFPGAHRQ-----ITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEK 276 Query: 306 --KSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAE 363 + + +++ ++ + G TTS TL++ M + +V E +++E+ Sbjct: 277 SNQHTEFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHR 336 Query: 364 GDISKMLQMVPLLKASIKETLRLHPI-SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMG 422 + +P A I E R + + D + + YL+P T V + + Sbjct: 337 LPTLEDRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSAL 396 Query: 423 RDPAFFSSPDKFDPTRWLSKDKDLIHF-RNLGFGWGVRQCVGRRIAELEMTLFLIHILEN 481 DP +F P F+P +L + L + F G R C+G IA E+ LF IL+N Sbjct: 397 HDPQYFEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQN 456 Query: 482 FKVEMQHIG-DVD 493 F V D+D Sbjct: 457 FSVSSSVAPKDID 469 >3DL9-A nrPDB Length = 479 Score = 263 bits (673), Expect = 9e-71, Method: Composition-based stats. Identities = 85/450 (18%), Positives = 168/450 (37%), Gaps = 25/450 (5%) Query: 75 HFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAH-LFKFEGSYPERYDIPPWLAYHR-- 131 H + Q YG I+ LG + +V + + V L + +R +P ++ + Sbjct: 37 HVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMG 96 Query: 132 -YYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQG 190 G + R+ +N+ K+F + ++ F + + K + Sbjct: 97 GLLNSRYGRGWVD-----HRRLAVNSFRYFGYGQKSFESKILEETKFFNDAI-ETYKGR- 149 Query: 191 SGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNV 250 D K+ + + ++FGER + + F + V SV L N Sbjct: 150 ----PFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNA 205 Query: 251 PPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEK- 309 P + L K + +++ + E + + + L + + + Sbjct: 206 FPWIGILPFGKH-QQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKND 264 Query: 310 ----MLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGD 365 E++ ++ E++ G TT+ L+W + MA N+Q +++E+ Sbjct: 265 PSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP 324 Query: 366 ISKMLQMVPLLKASIKETLRL-HPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRD 424 +P +A + E LR + + + + D V++ Y IP T V +Y++ D Sbjct: 325 SWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFD 384 Query: 425 PAFFSSPDKFDPTRWLSKDKDLIHFRNL-GFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 ++ P+ F P R+L L F G R C+G +A +EM LF +L+ F Sbjct: 385 EKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH 444 Query: 484 VEMQH--IGDVDTIFNLILTPDKPIFLVFR 511 + H + D+ + L P + R Sbjct: 445 LHFPHELVPDLKPRLGMTLQPQPYLICAER 474 >3IBD-A nrPDB Length = 476 Score = 262 bits (669), Expect = 3e-70, Method: Composition-based stats. Identities = 87/454 (19%), Positives = 152/454 (33%), Gaps = 39/454 (8%) Query: 61 NLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAH-LFKFEGSYPE 119 NL R + + +KYG ++ LG V + E + L ++ Sbjct: 23 NLLQMDRRGLLK----SFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSG 78 Query: 120 RYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRV----VLNTEVMAPEAIKNFIPLLNPVS 175 R I A + + GV+F WK R + M +++ I + Sbjct: 79 RGKI----AMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERI---QEEA 131 Query: 176 QDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFID 235 Q + L K F+ I +++FG+R + E K ++ Sbjct: 132 QCLIEELRKSKGALMDPTFL------FQSITANIICSIVFGKRF----HYQDQEFLKMLN 181 Query: 236 AVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFR 295 Y+ F + EL+ F H + + Y + R + Sbjct: 182 LFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVY-KNLQEINAYIGHSVEKHRETLDPS 240 Query: 296 NYPGILYCLLKS---------EKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLN 346 ++ L + +++ N + G TTS TL++ M + + Sbjct: 241 APRDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 300 Query: 347 VQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHP-ISVTLQRYPESDLVLQD 405 V E + E+ +P +A I E R + + + + Sbjct: 301 VAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG 360 Query: 406 YLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHF-RNLGFGWGVRQCVGR 464 Y+IP T V + + DP +F PD F+P +L + L + F G R C+G Sbjct: 361 YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGE 420 Query: 465 RIAELEMTLFLIHILENFKVEMQHIG-DVDTIFN 497 IA E+ LF IL+NF + D+D Sbjct: 421 GIARAELFLFFTTILQNFSMASPVAPEDIDLTPQ 454 >4R1Z-A nrPDB Length = 439 Score = 260 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 86/437 (19%), Positives = 178/437 (40%), Gaps = 43/437 (9%) Query: 93 LGNLESVYIIHPEDVAHLFKFEGS-YPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDR 151 +G+ + + + + + +G + R R S TWK R Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTR--DGKDIAFADYSSTWKFHR 58 Query: 152 VVLNTEV-MAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESI 210 +++ + M E + ++ + +L + D+ +L + Sbjct: 59 KMVHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSA------VDLGPELTRAVTNVV 112 Query: 211 TNVMFG---ERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHV 267 + F +R E++ +Q +D V K L+++ P L +D Sbjct: 113 CALCFNSSYKRGDAEFESMLQYSQGIVDTVAK-----DSLVDIFPWLQIFPN----KDLT 163 Query: 268 AAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEK-------------MLLED 314 I + +K + Y++ + +L LL++++ + + Sbjct: 164 ILRQCI-SIRDKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDH 222 Query: 315 VKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVP 374 V + ++ GV TT+ L+W + + + VQ ++EE+ + + +P Sbjct: 223 VLMTVGDIFGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLP 282 Query: 375 LLKASIKETLRLHPI-SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDK 433 L+A+I+E LR+ P+ + + D + +Y + T V + ++++ D + +P+ Sbjct: 283 YLEATIREVLRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPEL 342 Query: 434 FDPTRWLSKDKDL---IHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEM---Q 487 FDP R+L+++ D L FG GVR C+G +A++E+ LFL IL+ F +EM Q Sbjct: 343 FDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQ 402 Query: 488 HIGDVDTIFNLILTPDK 504 + D+ F ++L P K Sbjct: 403 PLPDLQGKFGVVLQPKK 419 >4H1N-A nrPDB Length = 479 Score = 259 bits (662), Expect = 2e-69, Method: Composition-based stats. Identities = 94/478 (19%), Positives = 165/478 (34%), Gaps = 49/478 (10%) Query: 36 EGAGISTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGN 95 +G +P P NL R KG R R E KYG ++ LG+ Sbjct: 8 KGKLPPGPSPLPVLG----------NLLQMDR-KGLLRSFLRLRE---KYGDVFTVYLGS 53 Query: 96 LESVYIIHPEDVAHLFKFEGS-YPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRV-- 152 V + + + + + R I A + GV+F W+ R Sbjct: 54 RPVVVLCGTDAIREALVDQAEAFSGRGKI----AVVDPIFQGYGVIFANGERWRALRRFS 109 Query: 153 --VLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESI 210 + M +++ I ++ V L K S + D I Sbjct: 110 LATMRDFGMGKRSVEERI---QEEARCLVEELRK------SKGALLDNTLLFHSITSNII 160 Query: 211 TNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAW 270 +++FG+R + P + +D ++ F + EL+ F H + Sbjct: 161 CSIVFGKRFDYKD----PVFLRLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIY 216 Query: 271 DTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLK---------SEKMLLEDVKANITE 321 + + + + R + N + L S + +++ + Sbjct: 217 RNL-QEINTFIGQSVEKHRATLDPSNPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLS 275 Query: 322 MLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIK 381 + A G TTS TL++ M + +V E +++E+ +P A I Sbjct: 276 LFAAGTETTSTTLRYGFLLMLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIH 335 Query: 382 ETLRL-HPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWL 440 E RL I + D + Y+IP T V + + DP +F +P+ F+P +L Sbjct: 336 EIQRLGDLIPFGVPHTVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFL 395 Query: 441 SKDKD-LIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIG-DVDTIF 496 + + + F G R C+G IA E+ LF IL+NF + D+D Sbjct: 396 DANGALKRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTP 453 >2X2N-A nrPDB Length = 475 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 73/438 (16%), Positives = 166/438 (37%), Gaps = 38/438 (8%) Query: 77 RHIENFQKYGP-IYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQK 135 E ++ I+ + + P + + F ++ + + + Sbjct: 41 FMQECKRQLKSGIFTINIVGKRVTIVGDPHEHSRFFLPRNEVLSPREV--YSFMVPVFGE 98 Query: 136 PIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFV 195 GV + ++++ E + +NF+P + + F++ + Sbjct: 99 --GVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAA------NWDKDEGE 150 Query: 196 GDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELY 255 ++ ED + +FGE L +A++F + KM + +P P L Sbjct: 151 INLLEDCSTMIINTACQCLFGEDL-----RKRLDARRFAQLLAKMESSLIPAAVFLPILL 205 Query: 256 RLFRTKTWR--DHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKS-----E 308 +L ++ R + I ++ I + + + +L LL + Sbjct: 206 KLPLPQSARCHEARTELQKILSEI-----IIARKAAAVNKDSSTSDLLSGLLSAVYRDGT 260 Query: 309 KMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQ--EMLREEVLNARRQAEGDI 366 M L +V I + G +T+S+T W + + NV+ E LR+E+ A+ + Sbjct: 261 PMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEE--FPAQLNY 318 Query: 367 SKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPA 426 + ++ +P + +E++R P + L R +D+ + Y++P ++ + D Sbjct: 319 NNVMDEMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLLSHHDEE 378 Query: 427 FFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEM 486 F P ++DP R + + +GFG GV +C+G++ L++ L ++ ++ Sbjct: 379 AFPEPRRWDPER-----DEKVEGAFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQL 433 Query: 487 QHIGDVDT-IFNLILTPD 503 D +++ P Sbjct: 434 LRDEVPDPDYHTMVVGPT 451 >2PG7-A nrPDB Length = 476 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 89/500 (17%), Positives = 182/500 (36%), Gaps = 53/500 (10%) Query: 36 EGAGISTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGN 95 +G TP P+ G+ LN + ++ ++YGP++ LG Sbjct: 8 KGKLPPGPTPLPFI-----GNYLQLNTEQMYNS---------LMKISERYGPVFTIHLGP 53 Query: 96 LESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLN 155 V + + V E + A + K GV+F K+ R Sbjct: 54 RRVVVLCGHDAVREALV---DQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRR--- 107 Query: 156 TEVMAPEAIKNF---IPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITN 212 + +++F + Q+ L ++ G L I++ Sbjct: 108 ---FSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFF--LSRTVSNVISS 162 Query: 213 VMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRT--KTWRDHVAAW 270 ++FG+R ++ E + + +F + +LY +F + K Sbjct: 163 IVFGDRFDYKDK----EFLSLLRMMLGIFQFTSTSTG---QLYEMFSSVMKHLPGPQQQA 215 Query: 271 DTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLL---------KSEKMLLEDVKANITE 321 + E + + +R + + + L + + L+++ + Sbjct: 216 FQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQ 275 Query: 322 MLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIK 381 + GG T S TL++ + + V+ + EE+ + + +P ++A I Sbjct: 276 LFVGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIH 335 Query: 382 ETLRLHPI-SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWL 440 E R + ++L R + D +D+ +P T V + ++ RDP+FFS+P F+P +L Sbjct: 336 EIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFL 395 Query: 441 SKDKDLIHF-RNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVE-MQHIGDVDTIF-- 496 ++ + F G R C G +A +E+ LF +++NF+++ Q D+D Sbjct: 396 NEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKH 455 Query: 497 -NLILTPDKPIFLVFRPFNQ 515 P + F P + Sbjct: 456 VGFATIPRNYT-MSFLPRHH 474 >2HI4-A nrPDB Length = 495 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 90/481 (18%), Positives = 173/481 (35%), Gaps = 28/481 (5%) Query: 39 GISTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLES 98 G+ + P+ P P GW L H + H Q+YG + + ++G+ Sbjct: 6 GLRPRVPKGLKSPPEP--WGWPLLGHVLTLG--KNPHLALSRMSQRYGDVLQIRIGSTPV 61 Query: 99 VYIIHPEDVAHLFKFEGS-YPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRV----V 153 + + + + +G + R D+ + + + + W R Sbjct: 62 LVLSRLDTIRQALVRQGDDFKGRPDL--YTSTLITDGQSLTFSTDSGPVWAARRRLAQNA 119 Query: 154 LNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNV 213 LNT +A + + L L R+++ +G D + I + Sbjct: 120 LNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAM 179 Query: 214 MFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTI 273 FG+ + + + + V + PL P + R + A Sbjct: 180 CFGQHFPESSDEMLSLVKNTHEFVETASSGN-PLDFFP--ILRYLPNPALQRFKAFNQRF 236 Query: 274 FNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEK------MLLEDVKANITEMLAGGV 327 +K + YQD K R+ G L+ K + E + + ++ G Sbjct: 237 LWFLQKTVQEHYQDF-DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGF 295 Query: 328 NTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLH 387 +T + + W L + +Q +++E+ + +P L+A I ET R Sbjct: 296 DTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHS 355 Query: 388 P-ISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDK-- 444 + T+ D L + IP K V V + + DP + P +F P R+L+ D Sbjct: 356 SFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTA 415 Query: 445 --DLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQH--IGDVDTIFNLIL 500 + + + FG G R+C+G +A+ E+ LFL +L+ + + D+ I+ L + Sbjct: 416 INKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTM 475 Query: 501 T 501 Sbjct: 476 K 476 >6DWN-A nrPDB Length = 491 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 83/474 (17%), Positives = 170/474 (35%), Gaps = 41/474 (8%) Query: 54 PGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKF 113 PG GW + H + H Q+YG + + ++G+ V + + + Sbjct: 14 PGPWGWPLIGHMLTLG--KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVR 71 Query: 114 EG-SYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVV----LNTEVMAPEAIKNFI 168 +G + R D+ + + + W R + L + +A + + Sbjct: 72 QGDDFKGRPDL--YTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTS 129 Query: 169 PLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNP 228 L +L +++ +G + + I + FG R + + Sbjct: 130 CYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLS 189 Query: 229 EAQ------------KFIDAVYKMFHTSVPLLNVPPELYRL---FRTKTWRDHVAAWDTI 273 D + + + P LN +L F K ++H ++ Sbjct: 190 LVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEK- 248 Query: 274 FNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMT 333 T+ + + K N + ++ E + + ++ G +T + Sbjct: 249 -GHIRDITDSLIEHCQEKQLDENA---------NVQLSDEKIINIVLDLFGAGFDTVTTA 298 Query: 334 LQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHP-ISVT 392 + W L + + VQ ++EE+ ++ +P ++A I ET R + T Sbjct: 299 ISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFT 358 Query: 393 LQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDK---DLIHF 449 + D L+ + IP V V + + D + +P +F P R+L+ D ++ Sbjct: 359 IPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSE 418 Query: 450 RNLGFGWGVRQCVGRRIAELEMTLFLIHILEN--FKVEMQHIGDVDTIFNLILT 501 + + FG G R+C+G IA E+ LFL +L+ F V + D+ I+ L + Sbjct: 419 KVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMK 472 >3JUS-A nrPDB Length = 461 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 77/451 (17%), Positives = 162/451 (35%), Gaps = 49/451 (10%) Query: 73 RIHFRHIEN-FQKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHR 131 + +EN ++KYGP++ + Y++ + A LF + D+ Y R Sbjct: 31 KSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNE-----DLNAEDVYSR 85 Query: 132 YYQK--PIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQ 189 GV + ++ + + K + ++ ++++ + ++ Sbjct: 86 LTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEK- 144 Query: 190 GSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLN 249 ++ E L + ++ + G+ + + +D + Sbjct: 145 -------NVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWL----- 192 Query: 250 VPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKS-- 307 +P L + R H D + + +R+ IL LL + Sbjct: 193 LPGWLPLPSFRRRDRAHREIKDIFYKAIQ----------KRRQSQEKIDDILQTLLDATY 242 Query: 308 ---EKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEG 364 + ++V + +L G +T+S T W + +AR +Q+ E + Sbjct: 243 KDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLP 302 Query: 365 DIS-KMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGR 423 ++ L+ + LL IKETLRL P + + R + + Y IP V V+ R Sbjct: 303 PLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQR 362 Query: 424 DPAFFSSPDKFDPTRWLSKD-KDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 + F+P R+L + F + FG G +C+G A +++ +L + Sbjct: 363 LKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLY 422 Query: 483 KVEMQHIGDVDTIF------NLILTPDKPIF 507 + ++ +D F +I TP+ P+ Sbjct: 423 EFDL-----IDGYFPTVNYTTMIHTPENPVI 448 >6AYB-A nrPDB Length = 466 Score = 238 bits (607), Expect = 5e-63, Method: Composition-based stats. Identities = 81/467 (17%), Positives = 174/467 (37%), Gaps = 22/467 (4%) Query: 54 PGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKF 113 P L Y ++ I+N +KYG ++ + E ++ HP+ + FK Sbjct: 12 PPRVPNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFLNHPKILDTFFKA 71 Query: 114 EGSYPERYDIPPWLAYHRYYQKPIGVLFK-KSGTWKKDRVVLNTEVMAPEAIKNFIPLLN 172 + D+ + + GV++ S ++V + + + F+ + Sbjct: 72 TDNELSLRDV--YRFMRPVFGT--GVVYDADSTERMMEQVKFVSSGLTTARFRVFVDIFE 127 Query: 173 PVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERL-GMLEETVNPEAQ 231 + + + + D+ E + + + + G+ + L E + Sbjct: 128 D---EIAHKVKEL-----GPEGTVDVAELMADLIIFTASRCLLGDEVRQYLSEKNLGKLY 179 Query: 232 KFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRK 291 ID P L P R K + + + +K + + + L + Sbjct: 180 HDIDDGISPLSFFYPSLPAP------KRDKARKAVGEIFQELLDKRREEHKKHPERLLDE 233 Query: 292 TEFRNYPGILYCLLKSEKMLLE-DVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEM 350 ++ +L K + L + + L G +T+S+T W L + + V E Sbjct: 234 SKMDVVDHLLTQKYKDGQELTDVHRIGILIAGLFAGQHTSSITSSWTLMNVISNKKVLEK 293 Query: 351 LREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPA 410 +R+E + + + L+A +KE LR++P + + R + Y+IP Sbjct: 294 VRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPLIMIMRMARKPRECEQYIIPK 353 Query: 411 KTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSK-DKDLIHFRNLGFGWGVRQCVGRRIAEL 469 ++ V+ GR +++PD FDP R + + + + + FG G +C+G A L Sbjct: 354 GNILVVSPSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGAVPFGAGRHKCIGENFALL 413 Query: 470 EMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQD 516 ++ + +L F +E + +L++ P P + ++ Q Sbjct: 414 QVKSIISILLRYFDMEYIGKIPDPSYTSLVVGPSPPTRMRYKLRKQQ 460 >3TBG-A nrPDB Length = 479 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 77/468 (16%), Positives = 163/468 (34%), Gaps = 42/468 (8%) Query: 71 SQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKFEG-SYPERYDIPPWLAY 129 Q + + +++G ++ +L V + V G +R +P Sbjct: 29 FQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQIL 88 Query: 130 HRYYQKPIGVLFKKSGTWKKDRV----VLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKR 185 + L + W++ R L + ++++ + + + Sbjct: 89 GFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQ---WVTEEAACLCAAFANH 145 Query: 186 IKQQGSGKFVGDIKEDLFHFAFESITNVMFGER-------LGMLEETVNPEA---QKFID 235 + + D + + + F L + +E + E+ ++ ++ Sbjct: 146 SGRPFRPNGLLD--KAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLN 203 Query: 236 AVYKMFHTSVPLLNVPPELYRLFRTKT---WRDHVAAWDTIFNKAEKYTEIFYQDLRRKT 292 AV + H L + F T+ +H WD TE F ++ + Sbjct: 204 AVPVLLHIP-ALAGKVLRFQKAFLTQLDELLTEHRMTWD-PAQPPRDLTEAFLAEMEKAK 261 Query: 293 EFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLR 352 E+++ + ++ + G+ TTS TL W L M +VQ ++ Sbjct: 262 GNPE-----------SSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQ 310 Query: 353 EEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHP-ISVTLQRYPESDLVLQDYLIPAK 411 +E+ + Q +P A I E R + + + D+ +Q + IP Sbjct: 311 QEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKG 370 Query: 412 TLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHF-RNLGFGWGVRQCVGRRIAELE 470 T + + ++ +D A + P +F P +L + L F G R C+G +A +E Sbjct: 371 TTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARME 430 Query: 471 MTLFLIHILENFKVEM---QHIGDVDTIFNLILTPDKPIFLVFRPFNQ 515 + LF +L++F + Q +F +++P P L P + Sbjct: 431 LFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPS-PYELCAVPRHH 477 >6IQ5-A nrPDB Length = 463 Score = 228 bits (580), Expect = 6e-60, Method: Composition-based stats. Identities = 83/458 (18%), Positives = 173/458 (37%), Gaps = 41/458 (8%) Query: 75 HFRHIENFQKYGPIYREKLGNLESVYIIHPEDV-AHLFKFEGSYPERYDIPPWLAYHRYY 133 H ++YG +++ +LG+ V + + L + ++ +R P + ++ Sbjct: 4 HLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADR---PSFASFRVVS 60 Query: 134 QKPIGVLFKKSGTWKKDRVVL-----NTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQ 188 S WK R N P + + + +++ V+LL ++ Sbjct: 61 GGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALL---VRG 117 Query: 189 QGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFID--AVYKMFHTSVP 246 G F+ D ++ NVM G +PE ++ + + + Sbjct: 118 SADGAFL-----DPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGS 172 Query: 247 LLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYT-EIFYQDLRRKTEFRNYPGILYCLL 305 L++V P L R ++ + + + F + ++ + Sbjct: 173 LVDVMPWLQYFPNP--VRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFI 230 Query: 306 KSEK-------------MLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLR 352 S + + LE+V A IT++ +T S LQW L R +VQ ++ Sbjct: 231 LSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQ 290 Query: 353 EEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHP-ISVTLQRYPESDLVLQDYLIPAK 411 E+ + +P + A + E +R + VT+ ++ + Y IP Sbjct: 291 AELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKD 350 Query: 412 TLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDK---DLIHFRNLGFGWGVRQCVGRRIAE 468 T+V V +++ DP + +P+ FDP R+L KD + R + F G R+C+G +++ Sbjct: 351 TVVFVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSK 410 Query: 469 LEMTLFLIHILEN--FKVEMQHIGDVDTIFNLILTPDK 504 +++ LF+ + F+ ++ + L + P Sbjct: 411 MQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKS 448 >6C94-A nrPDB Length = 497 Score = 227 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 73/396 (18%), Positives = 146/396 (36%), Gaps = 15/396 (3%) Query: 135 KPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKF 194 G+L W + R + + P + + + D ++ ++ +++ Sbjct: 100 IGKGLLVLDGPKWFQHRKL-----LTPGFHYDVLKPYVAIFADSTRIMLEKWEKKACEGK 154 Query: 195 VGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKM------FHTSVPLL 248 DI D+ H A +++ FG+ L + + M F + Sbjct: 155 SFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSYYVAVSELTLLMQQRIDSFQYHNDFI 214 Query: 249 NVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSE 308 R F H I + + ++ + ++ IL + Sbjct: 215 YWLTPHGRRFLRACRAAHDHTDRVIRQRKAALQDEKEREKIQNRRHLDFLDILLDVRGES 274 Query: 309 --KMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDI 366 ++ D++A + + G +TT+ + W LY MA Q+ REEV + Sbjct: 275 GVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQRCREEVREILGDQDSFQ 334 Query: 367 SKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLV-LQDYLIPAKTLVQVAIYAMGRDP 425 + L + L +KE RL+P + R + + +PA +L+ + IYA+ R+ Sbjct: 335 WEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKPVSFVDGRSLPAGSLISLHIYALHRNS 394 Query: 426 AFFSSPDKFDPTRWLSKDKDLIH-FRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKV 484 + P+ FDP R+ ++ H + + F G R C+G++ A EM + L F+ Sbjct: 395 DVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEF 454 Query: 485 EMQHIGDVDTIFNLILTPDKPIFLVFRPFNQDPPQA 520 + + + L+L I L +P ++ Sbjct: 455 SVDPLRLPIKLPQLVLRSKNGIHLYLKPLGPKAEKS 490 >6CR2-A nrPDB Length = 477 Score = 218 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 73/456 (16%), Positives = 158/456 (34%), Gaps = 48/456 (10%) Query: 77 RHIENFQKYGPIYR-EKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQK 135 + KYG I+ LG +VY+ + F G + + Sbjct: 29 FFFDCRAKYGDIFTFILLGKKTTVYLGTK---GNDFILNGKLRDVCAEEVYSPLTTPVFG 85 Query: 136 PIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFV 195 V++ ++ + +A+++++PL+ + FV +G V Sbjct: 86 RH-VVYDCPNAKLMEQKKFVKYGLTSDALRSYVPLITDEVESFVKNSPAFQGHKG----V 140 Query: 196 GDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELY 255 D+ + + + + + G+ + ++ E +D + + +P +P Sbjct: 141 FDVCKTIAEITIYTASRSLQGKEVRSKFDSTFAELYHNLDMGFAPINFMLPWAPLP---- 196 Query: 256 RLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLL-----KSEKM 310 H D K + + R+ ++ +++ L+ + Sbjct: 197 ----------HNRKRDAAQRKLTETYMEIIKARRQAGSKKDSEDMVWNLMSCVYKNGTPV 246 Query: 311 LLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDIS-KM 369 E++ + +L G +++S T W + +A ++ E L +E + ++ Sbjct: 247 PDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLGSDLPPLTYDN 306 Query: 370 LQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQD--YLIPAKTLVQVAIYAMGRDPAF 427 LQ + L IKETLRLH ++ R ++ + + Y+IP V + R Sbjct: 307 LQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEH 366 Query: 428 FSSPDKFDPTRWLSKDK-----------------DLIHFRNLGFGWGVRQCVGRRIAELE 470 F +P +++P RW + L FG G +C+G + A L+ Sbjct: 367 FPNPLEWNPHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQ 426 Query: 471 MTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPI 506 + ++ F+ D + KP+ Sbjct: 427 LGTITAVLVRLFRFRNLPGVDGIPDTDYSSLFSKPL 462 >2W0A-A nrPDB Length = 455 Score = 212 bits (540), Expect = 3e-55, Method: Composition-based stats. Identities = 72/449 (16%), Positives = 158/449 (35%), Gaps = 32/449 (7%) Query: 71 SQRIHFRHIENFQ-KYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAY 129 + ++ + + G + +L + V + F+ + + Sbjct: 22 FRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHANEFFFRAGDD--DLDQAKAYPFM 79 Query: 130 HRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQ 189 + + V+F S +K+ +L+ + E +K + + + I Sbjct: 80 TPIFGEA--VVFDASPERRKE--MLHNAALRGEQMKGHAATIEDQVR-------RMIADW 128 Query: 190 GSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLN 249 G + D+ + + + + G++ + + ++ P L Sbjct: 129 GEAGEI-DLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYL- 186 Query: 250 VPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCL---LK 306 P E +R RD A + + + R+ +L + Sbjct: 187 -PIESFR------RRD--EARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETG 237 Query: 307 SEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDI 366 + + +++ M+ G +T+S T W L E+ R + + +E+ Sbjct: 238 TPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVS 297 Query: 367 SKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPA 426 L+ +P L+ +KETLRLHP + L R + + +Q + I LV + R P Sbjct: 298 FHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPE 357 Query: 427 FFSSPDKFDPTRW--LSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKV 484 F P F P R+ ++ L + + FG G +CVG A +++ +L ++ Sbjct: 358 DFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEF 417 Query: 485 EMQHIGDV--DTIFNLILTPDKPIFLVFR 511 EM + + +++ +P + +R Sbjct: 418 EMAQPPESYRNDHSKMVVQLAQPAAVRYR 446 >3S79-A nrPDB Length = 503 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 86/438 (19%), Positives = 174/438 (39%), Gaps = 26/438 (5%) Query: 85 YGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKS 144 YG R + E++ I + H+ Y R+ L G++F + Sbjct: 81 YGEFMRVWISGEETLIISKSSSMFHIM-KHNHYSSRFGSK--LGLQCIGMHEKGIIFNNN 137 Query: 145 GTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFH 204 K + ++ + + + + + L + + G D+ L Sbjct: 138 PELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESG----YVDVLTLLRR 193 Query: 205 FAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWR 264 ++ + R+ + E + + Q + DA + + LY+ + K+ + Sbjct: 194 VMLDTSNTLFL--RIPLDESAIVVKIQGYFDAWQALLIKPDIFFKI-SWLYKKY-EKSVK 249 Query: 265 DHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLA 324 D A + + + + + E ++ L K + E+V I EML Sbjct: 250 DLKDAIEVLIAEKRRRI----STEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLI 305 Query: 325 GGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETL 384 +T S++L + L+ +A+ NV+E + +E+ + + I +Q + +++ I E++ Sbjct: 306 AAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKI-DDIQKLKVMENFIYESM 364 Query: 385 RLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDK 444 R P+ + R D V+ Y + T + + I M R FF P++F + K Sbjct: 365 RYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFA---K 420 Query: 445 DLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEM---QHIGDVDTIFNLILT 501 ++ + FG+G R C G+ IA + M L+ +L F V+ Q + + I +L L Sbjct: 421 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480 Query: 502 PDKP---IFLVFRPFNQD 516 PD+ + ++F P N D Sbjct: 481 PDETKNMLEMIFTPRNSD 498 >3EJB-B nrPDB Length = 404 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 59/313 (18%), Positives = 112/313 (35%), Gaps = 46/313 (14%) Query: 183 HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFH 242 H+R++ SG F E + E++ +++ + E ++ A V Sbjct: 88 HRRLRTLASGAFTPRTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIAN-- 145 Query: 243 TSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEI---------FYQDLRRKTE 293 ++ VP E K W + + TE ++++L +K + Sbjct: 146 ----IIGVPEEDREQL--KEWAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRK 199 Query: 294 FRNYPGILYCLLKS---EKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEM 350 ++ LLK +K+ E+ + + G TT + + + + Sbjct: 200 RHPQQDMISMLLKGREKDKLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLK 259 Query: 351 LREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPA 410 LRE L+ +++E LR + R D+ + I Sbjct: 260 LRE------------------NPDLIGTAVEECLRYESPTQMTARVASEDIDICGVTIRQ 301 Query: 411 KTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELE 470 V + + A RDP+ F++PD FD TR + +L FG G C+G +A LE Sbjct: 302 GEQVYLLLGAANRDPSIFTNPDVFDITRSPNP--------HLSFGHGHHVCLGSSLARLE 353 Query: 471 MTLFLIHILENFK 483 + + +L+ Sbjct: 354 AQIAINTLLQRMP 366 >5OFQ-A nrPDB Length = 409 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 67/415 (16%), Positives = 140/415 (33%), Gaps = 94/415 (22%) Query: 101 IIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMA 160 + E V ++ K + + + ++ +L K R L + Sbjct: 54 VFDYETVKYILKNPSLFSSKRAME---------ERQESILMMDPPKHTKLR-NLVNKAFT 103 Query: 161 PEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLG 220 P AI++ + ++ + + + E+ Sbjct: 104 PRAIQHLEGHIEEIADYLLDEVSSK-------------------------------EKFD 132 Query: 221 MLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWR----------DHVAAW 270 ++E+ P LL VP + LF+ + + A Sbjct: 133 IVEDFAGPL----------PIIVIAELLGVPIQDRALFKKYSDDLVSGAENNSDEAFAKM 182 Query: 271 DTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSE----KMLLEDVKANITEMLAGG 326 N+ + + +++++ + + ++ LL++E + E+V +L G Sbjct: 183 MQKRNEGVIFLQGYFKEIIAERQQNKQEDLISLLLEAEIDGEHLTEEEVLGFCILLLVAG 242 Query: 327 VNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRL 386 TT+ + + M ++VQ +R ++ L+ ++ETLR Sbjct: 243 NETTTNLITNGVRYMTEDVDVQNEVRRDI------------------SLVPNLVEETLRY 284 Query: 387 HPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDL 446 +P + R D+ L + I V + RD A F PD F R + Sbjct: 285 YPPIQAIGRIAAEDVELGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHRKTNP---- 340 Query: 447 IHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILEN--FK-VEMQHIGDVDTIFNL 498 ++ FG+G+ C+G +A +E + +LE F V+ Q + +D+ F Sbjct: 341 ----HVSFGFGIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPIDSPFVF 391 >5L94-A nrPDB Length = 410 Score = 199 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 64/409 (15%), Positives = 136/409 (33%), Gaps = 64/409 (15%) Query: 101 IIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMA 160 + H + V + + + + P R ++ + R L + Sbjct: 49 VFHYDGVKEVLEQKNIFSSDRRPPQ---NQRQTALGTSLINIDPPKHAEMR-ALVNKAFT 104 Query: 161 PEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLG 220 P+A+K + P + ++ + + + DI E L + + + G + Sbjct: 105 PKAMKAWEPKIARITNELLQEVEHLED--------IDIVEHLSYPLPVMVIADILGVPIE 156 Query: 221 MLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKY 280 + + S ++ P R K ++ + A D + E Y Sbjct: 157 DQRQFKD---------------WSDIIVAGPSNNERETLEKLQQEKMKANDEL----ETY 197 Query: 281 TEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYE 340 ++ R + +L + +++ E++ +L G TT+ + +Y Sbjct: 198 FYRIIEEKRTRPGDDIISVLLQAKEEGKQLTDEEIVGFSILLLIAGNETTTNLISNTIYC 257 Query: 341 MARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESD 400 + E L+ E LL + I+E LR L R + D Sbjct: 258 LMEDKASFERLKREK------------------ELLPSGIEEVLRYRSPVQALHRIVKED 299 Query: 401 LVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQ 460 + L + A V + + RD +F P+ F R + ++ FG G+ Sbjct: 300 VTLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDRKPN--------VHMAFGRGIHF 351 Query: 461 CVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLV 509 C+G +A +E + L +++ + +D + L P + F+ Sbjct: 352 CLGAPLARIEAKIMLAELIDRY-------PQMDWSPSFELKPIESTFVY 393 >4RM4-A nrPDB Length = 396 Score = 199 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 71/428 (16%), Positives = 148/428 (34%), Gaps = 64/428 (14%) Query: 67 REKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPW 126 + K F E+ +K P+ ++ + SV++ +DV + + + Sbjct: 18 KNKQDAYHPFPWYESMRKDAPVSFDEENQVWSVFL--YDDVKKVVGDKELFSSCMP---- 71 Query: 127 LAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRI 186 + ++ K R V+N P +K + P + ++ + + R Sbjct: 72 ---QQTSSIGNSIINMDPPKHTKIRSVVNK-AFTPRVMKQWEPRIQEITDELIQKFQGRS 127 Query: 187 KQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVP 246 + D+ D + + + + G +E+ S Sbjct: 128 E--------FDLVHDFSYPLPVIVISELLGVPSAHMEQFK---------------AWSDL 164 Query: 247 LLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLK 306 L++ P + + + + D + + ++ R K E ++ Sbjct: 165 LVSTPKD----KSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAEET 220 Query: 307 SEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDI 366 EK+ E++ T +L G TT+ + +Y + + V E LR Sbjct: 221 GEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELR-------------- 266 Query: 367 SKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPA 426 L+ +++E LR + L+R + D + +LI +V + + RD A Sbjct: 267 ----SHPELMPQAVEEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEA 322 Query: 427 FFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF-KVE 485 F P FD R + ++ FG G+ C+G +A LE + L ++ F +E Sbjct: 323 KFDRPHMFDIRRHPNP--------HIAFGHGIHFCLGAPLARLEANIALTSLISAFPHME 374 Query: 486 MQHIGDVD 493 I ++ Sbjct: 375 CVSITPIE 382 >4Z5P-A nrPDB Length = 400 Score = 198 bits (502), Expect = 7e-51, Method: Composition-based stats. Identities = 73/342 (21%), Positives = 126/342 (36%), Gaps = 51/342 (14%) Query: 159 MAPEAIKNFIPLLNPVSQDFVSLL------HKRIKQQGSGKFVGDIKEDLFHFAFESITN 212 + I P P+++ ++L H R+++ S F + + E Sbjct: 64 FSRAQIGEDTPRTTPLARRSDTILSLDPPEHTRLRRLLSKAFTARRMGAMQSWLEELFAG 123 Query: 213 VMFG-ERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWD 271 ++ G ER G + V AQ F AV LL VP E F + W + + + Sbjct: 124 LLDGVERTGHPADIVRDLAQPFTIAVI------CRLLGVPYEDRGRF--QHWSEVIMSTT 175 Query: 272 ----TIFNKAEKYTEIFYQDL---RRKTEFRNYPGILYCLLKSE-KMLLEDVKANITEML 323 A+ + DL RR + G+L + ++ +++ +L Sbjct: 176 AYSKEEAVSADASIRAYLADLVSARRAAPHDDLLGVLVSARDDDDRLTEDELITFGVTLL 235 Query: 324 AGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKET 383 G T++ L +Y + + +LRE LL +++E Sbjct: 236 VAGHETSAHQLGNMVYALLTHEDQLSLLRE------------------QPELLPRAVEEL 277 Query: 384 LRLHPISVTL--QRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLS 441 LR P+ + R D+ L + A V A RDP F PD+ D TR + Sbjct: 278 LRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITREKN 337 Query: 442 KDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 +L FG G C+G ++A +E+ + + +LE F Sbjct: 338 P--------HLAFGHGAHYCLGAQLARMELRVAIGGLLERFP 371 >6F0B-A nrPDB Length = 395 Score = 194 bits (493), Expect = 7e-50, Method: Composition-based stats. Identities = 69/337 (20%), Positives = 130/337 (38%), Gaps = 41/337 (12%) Query: 183 HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFH 242 H+R++ + +F+ E L E + V+ G L ET P+ AV Sbjct: 91 HRRLRGTIAREFLPKHIELLRPAIREIVQGVLDG-----LAETAPPQDMLEAFAVPVASA 145 Query: 243 TSVPLLNVPPELYRLFRTKTWRDHVAAWD------TIFNKAEKYTEIFYQDLRRKTEFRN 296 T LL +P E R T+ + V+A +F +Y QD E Sbjct: 146 TVFRLLGIPAED-RALLTRCVKGVVSAVGSEDEGAEVFRTLGEYIGGLVQDPSELPEDSL 204 Query: 297 YPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVL 356 ++ + +++ + I ++ GG +TT+ T+ L A ++ E Sbjct: 205 IRRLVTGPYQEKQLTFHETIGVILMLIVGGYDTTASTISLSLVSYALQPEKFSVVHEHP- 263 Query: 357 NARRQAEGDISKMLQMVPLLKASIKETLRLHPISV-TLQRYPESDLVLQDYLIPAKTLVQ 415 + +PLL ++E LR H +S L R D+ + + A +V Sbjct: 264 --------------ERIPLL---VEELLRYHTVSQLGLGRIATEDVEVGGVTVRAGQMVV 306 Query: 416 VAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFL 475 A+ RD + F +PD+ D R ++GFG+G QCVG+ +A +E+ + Sbjct: 307 AALPLANRDESVFPNPDELDFDR--------PSVPHVGFGYGPHQCVGQALARVELQEAI 358 Query: 476 IHILENFK-VEMQH-IGDVDTIFNLILTPDKPIFLVF 510 ++ + + + D+ ++ + + + Sbjct: 359 PAVIRRLPGMRLACALEDLPFRHDMATYGIHELPMTW 395 >3RWL-A nrPDB Length = 426 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 55/327 (16%), Positives = 118/327 (36%), Gaps = 46/327 (14%) Query: 183 HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFH 242 H ++ S L E ++ + G +G + V+ + + + Sbjct: 119 HDEQRKAVSPIVAPANLAALEGTIRERVSKTLDGLPVGEEFDWVDRVSIEITTQMLAT-- 176 Query: 243 TSVPLLNVPPELYRLFRTKTWRDH---------VAAWD---TIFNKAEKYTEIFYQDLRR 290 L + P E R W D V +WD T + Y ++ + + Sbjct: 177 ----LFDFPFEERRKLTR--WSDVTTAAPGGGVVESWDQRKTELLECAAYFQVLWNERVN 230 Query: 291 KTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEM 350 K + +L + M E+ N+ ++ GG +TT ++ + + ++ + Sbjct: 231 KDPGNDLISMLAHSPATRNMTPEEYLGNVLLLIVGGNDTTRNSMTGGVLALHKNPD---- 286 Query: 351 LREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPA 410 +K+ L++ + E +R ++R +D L I Sbjct: 287 --------------QFAKLKANPALVETMVPEIIRWQTPLAHMRRTAIADSELGGKTIRK 332 Query: 411 KTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELE 470 V + Y+ RD P++F R ++L FG+G+ +CVG R+AE++ Sbjct: 333 GDKVVMWYYSGNRDDEVIDRPEEFIIDR-------PRPRQHLSFGFGIHRCVGNRLAEMQ 385 Query: 471 MTLFLIHILENFKVEMQHIGDVDTIFN 497 + + IL F ++ + + + + + Sbjct: 386 LRILWEEILTRFS-RIEVMAEPERVRS 411 >5VWS-A nrPDB Length = 393 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 66/410 (16%), Positives = 131/410 (31%), Gaps = 91/410 (22%) Query: 87 PIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGT 146 P++R++ G ++ +DV + ++ G + Sbjct: 32 PVWRDQFG---IYHVFRYDDVRQILGDYQTFSSDRT----RLMPTAQGFGKGGITMIDPP 84 Query: 147 WKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFA 206 + + L T P++I P + ++ + L Sbjct: 85 EHRHQRRLITHAFTPQSISAMEPRIRQIADHLLDELP----------------------- 121 Query: 207 FESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDH 266 G ++E P LL VPP LFRT W D Sbjct: 122 ---------GPEFDLVEHFAYPL----------PVIVIAELLGVPPGDRHLFRT--WSDR 160 Query: 267 VAAWD-----------TIFNKAEKYTEIFYQDLRRK---TEFRNYPGILYCLLKSEKMLL 312 + + T+ + + + R + ++ ++ +++ L Sbjct: 161 LMSLQVENYADPELARTVAAAMTEMNDYLREHCRSRRTHPRDDLLTRLVQAEVEGKRLDL 220 Query: 313 EDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQM 372 E+V + +L G TT++ + + + ++ +R Sbjct: 221 EEVVNTASLLLLAGHLTTTVLIGNTMLCLWDHPEAEKAVR------------------AD 262 Query: 373 VPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPD 432 L+ A+++E+LRL + R D+ + IPA V I + D F P+ Sbjct: 263 PSLIPAALEESLRLRSPFLQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPE 322 Query: 433 KFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 +FD R + ++ FG GV C+G ++ LE + L +L F Sbjct: 323 RFDLHRQTTG--------HIAFGHGVHFCLGAQLGRLEGRIALERLLGRF 364 >3WVS-A nrPDB Length = 401 Score = 187 bits (475), Expect = 8e-48, Method: Composition-based stats. Identities = 67/392 (17%), Positives = 135/392 (34%), Gaps = 51/392 (13%) Query: 136 PIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLL-------HKRIKQ 188 P G + ++ R+VL + + P + H R+++ Sbjct: 44 PYGEPAWLATRYEDARLVLGDARFSRALSEEHDPPRARKFNAQAKSMFNMDAPDHTRLRR 103 Query: 189 QGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLL 248 S F E+L + ++ + + E + A A+ LL Sbjct: 104 LISKAFTIRRVEELRPKVHDLAHRLI--DDMLAKGEPADLVAD---YALPIPTTVICELL 158 Query: 249 NVPPELYRLFRTKTWRDHVAAWDTIFNKAEK--------YTEIFYQDLRRKTEFRNYPGI 300 VP E F W D + + T+ + + Y R + G+ Sbjct: 159 GVPFEDREKFGR--WTDAILSTSTLNPEEGRVKRMELVGYIGGIIAARRAQPADDLISGM 216 Query: 301 LYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARR 360 + +K+ +++ + +L G TT+ + +Y + + L Sbjct: 217 IEARDVQDKLTEQELLDHCIGLLIAGHETTASQIPSFVYALLDQPQHWKRL--------- 267 Query: 361 QAEGDISKMLQMVPLLKASIKETLRLHPISVT--LQRYPESDLVLQDYLIPAKTLVQVAI 418 L L+ ++++E R P+ RY D+ + L+ A V VA+ Sbjct: 268 ---------LDDPELIPSAVEELFRFVPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVAL 318 Query: 419 YAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHI 478 A RD F P++ R + ++GFG G+ C+G +A LE+ L + Sbjct: 319 GAANRDGLRFEDPEEIKLDRPSN--------HHIGFGHGIHHCLGAPLARLELQEALRAL 370 Query: 479 LENFKVEMQHIGDVDTIFNLILTPDKPIFLVF 510 LE ++ GD+ +++ + + + + Sbjct: 371 LERLPT-LKVAGDIAWKSEMMVRGPRSMPVGW 401 >6B11-A nrPDB Length = 440 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 74/405 (18%), Positives = 138/405 (34%), Gaps = 53/405 (13%) Query: 123 IPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMA-------PEAIKNFIPLLNPVS 175 + A L+ + W R ++A P + P + + Sbjct: 66 PEQYAALRAEEPIARAELWDGAPVWLISRQDHVRALLADPRVSIHPAKLPRLSPS-DGEA 124 Query: 176 QDFVSLL------HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPE 229 + SLL H ++ +F +L + +T ++ + L + + Sbjct: 125 EASRSLLTLDPPDHGALRGHFIPEFGLRRVRELRPSVEQIVTGLL--DDLTARGDEADLL 182 Query: 230 AQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKA----EKYTEIFY 285 A A+ LL++P E F+ +T + A +A Y + Sbjct: 183 AD---FALPMATQVICRLLDIPYEDRDYFQERTEQATRPAAGEEALEALLELRDYLDRLI 239 Query: 286 QDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSL 345 + G + + + DV N +LA G TT+ + + + + Sbjct: 240 SGKTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMSVLVLLQHP 299 Query: 346 NVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQD 405 L LL ++ E LR I+ L+R +D+ + Sbjct: 300 TAWREL------------------TVNPGLLPGAVDELLRYLSIADGLRRSATADIEIDG 341 Query: 406 YLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRR 465 + I A + + A RD A FS P+ FD R R++ FG+G QC+G+ Sbjct: 342 HTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHRSA--------RRHVAFGYGPHQCLGQN 393 Query: 466 IAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVF 510 +A +E+ + L +LE + + + L L D +F V+ Sbjct: 394 LARMELEVALGAVLER----LPALRPTTDVAGLRLKSDSAVFGVY 434 >1F4U-A nrPDB Length = 368 Score = 186 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 74/338 (21%), Positives = 125/338 (36%), Gaps = 61/338 (18%) Query: 183 HKRIKQQGSGKFVGDIK--------EDLFHFAFESITNVMFG-ERLGMLEETVNPEAQKF 233 H+R++ +GK DI + H S++ +F ++L LE + + Sbjct: 47 HERLEDLRNGKIRFDIPTRYTMLTSDPPLHDELRSMSADIFSPQKLQTLETFIRETTRSL 106 Query: 234 IDAV-------YKMFHTSVPL------LNVPPELYRLFRTKTWRDHVA----AWDTIFNK 276 +D++ K +P+ L +P E F K W D VA IF Sbjct: 107 LDSIDPREDDIVKKLAVPLPIIVISKILGLPIEDKEKF--KEWSDLVAFRLGKPGEIFEL 164 Query: 277 AEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQW 336 +KY E+ + + + + + I +L G TT+ + Sbjct: 165 GKKYLELIGYVKDHLNSGTE----VVSRVVNSNLSDIEKLGYIILLLIAGNETTTNLISN 220 Query: 337 HLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRY 396 + + R N+ + +REE L LKA I+E LR P + R Sbjct: 221 SVIDFTRF-NLWQRIREENL------------------YLKA-IEEALRYSPPVMRTVRK 260 Query: 397 PESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGW 456 + + L D I V+V I + RD F +KF P R + +L FG Sbjct: 261 TKERVKLGDQTIEEGEYVRVWIASANRDEEVFHDGEKFIPDRNPNP--------HLSFGS 312 Query: 457 GVRQCVGRRIAELEMTLFLIHILENFK-VEMQHIGDVD 493 G+ C+G +A LE + + + F+ +E+ V Sbjct: 313 GIHLCLGAPLARLEARIAIEEFSKRFRHIEILDTEKVP 350 >3OFT-A nrPDB Length = 396 Score = 185 bits (469), Expect = 4e-47, Method: Composition-based stats. Identities = 73/364 (20%), Positives = 127/364 (34%), Gaps = 61/364 (16%) Query: 150 DRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFES 209 + T VM A F+ L P Q L + ++ +GS FV D E L F + Sbjct: 93 EHKAFRTPVMKGLA-SRFVVALEPKVQAVARKLMESLRPRGSCDFVSDFAEILPLNIFLT 151 Query: 210 ITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAA 269 + +V +R P L +L T D Sbjct: 152 LIDVPLEDR---------------------------------PRLRQLGVQLTRPDGSMT 178 Query: 270 WDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNT 329 + + A+ Y F + + + IL + +++ + +L GG++T Sbjct: 179 VEQLKQAADDYLWPFIEKRMAQPGDDLFSRILSEPVGGRPWTVDEARRMCRNLLFGGLDT 238 Query: 330 TSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPI 389 + + +AR Q +LRE L+ A+ E +R +P Sbjct: 239 VAAMIGMVALHLARHPEDQRLLRE------------------RPDLIPAAADELMRRYP- 279 Query: 390 SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHF 449 +V + R +D+ I LV + DPA F +P++ R L+ Sbjct: 280 TVAVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGLAP------I 333 Query: 450 RNLGFGWGVRQCVGRRIAELEMTLFLIHILENF-KVEMQHIGDVDTIFNLILTPDKPIFL 508 R+ G G +CVG +A +E+ +FL L + + V T+ + + L Sbjct: 334 RHTTMGVGAHRCVGAGLARMEVIVFLREWLGGMPEFALAPDKAV-TMKGGNVGACTALPL 392 Query: 509 VFRP 512 V+R Sbjct: 393 VWRA 396 >6A7J-A nrPDB Length = 411 Score = 185 bits (469), Expect = 5e-47, Method: Composition-based stats. Identities = 72/446 (16%), Positives = 146/446 (32%), Gaps = 74/446 (16%) Query: 86 GPIYREKL-GNLESVYIIHPEDVAHLFKFEGSYP--------ERYDIPPWLAYHRYYQKP 136 GP+ +L G + + H ++ L +R +IP Sbjct: 26 GPLAEVELPGGVHVYAVTHHKEARALLTDSRVVKDINVWNAWQRGEIPADWPLIGLVNPG 85 Query: 137 IGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVG 196 +L ++ R + V+Q ++++ Sbjct: 86 RSMLTVDGPDHRRLRTL--------------------VAQALTVKRVEKLRAG------- 118 Query: 197 DIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYR 256 E L + + E + + GE + + E P I + + P L E + Sbjct: 119 --IEALTNASLERLAALPAGEPVDLKAEFAYPLPMNVISELMGVDAADHPRLKELFE--K 174 Query: 257 LFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVK 316 F T+T + V + ++ + ++ + + E++ Sbjct: 175 FFSTQTPPEEVP---QMMADLGTLFTKIVEEKKANPGDDLTSALIAASEDGDHLTDEEIL 231 Query: 317 ANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLL 376 + ++A G TT + + +A ++ + + +P Sbjct: 232 NTLQLIIAAGHETTISLIVNVVEALAIHPEQRKKV-----------------LSGEIP-W 273 Query: 377 KASIKETLRLHPI-SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFF-SSPDKF 434 + I+ETLR + S L R+ D+ + D ++P + V+ A+GRD + + F Sbjct: 274 EGVIEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGPTAGDF 333 Query: 435 DPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDT 494 D TR + R++ FG G C G ++ LE + L + E F + + Sbjct: 334 DATRTPN--------RHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPAAEL 385 Query: 495 IFNLILTPDKPIFLVFR---PFNQDP 517 I+T + L + PF D Sbjct: 386 RNKPIVTQNDLHDLPVKLGCPFGHDA 411 >4KPA-A nrPDB Length = 494 Score = 185 bits (468), Expect = 6e-47, Method: Composition-based stats. Identities = 79/466 (16%), Positives = 160/466 (34%), Gaps = 31/466 (6%) Query: 50 EIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAH 109 E+P P G L + + ++ + G I++ + + Y+ + Sbjct: 28 EMPQPKTFGELKNLPLLN---TDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKE 84 Query: 110 LFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIP 169 + S ++ + + + WKK ++ P + + Sbjct: 85 AC--DESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKK-----AHNILLPSFSQQAMK 137 Query: 170 LLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPE 229 + + D L ++ + + + ++ ED+ ++I F R + Sbjct: 138 GYHAMMVDIAVQLVQKWE-RLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFY---RDQ 193 Query: 230 AQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLR 289 FI ++ + ++ L + + + + D Sbjct: 194 PHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQ-----FQEDIKVMNDLVDKIIAD-- 246 Query: 290 RKTEFRNYPGILYCLLKS------EKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMAR 343 RK +L +L E + E+++ I L G TTS L + LY + + Sbjct: 247 RKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVK 306 Query: 344 SLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVL 403 + +V + EE K ++ + + + E LRL P + Y + D VL Sbjct: 307 NPHVLQKAAEEAARVLVDPVPSY-KQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVL 365 Query: 404 QD-YLIPAKTLVQVAIYAMGRDPAFF-SSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQC 461 Y + + V I + RD + ++F P R+ + H FG G R C Sbjct: 366 GGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQH-AFKPFGNGQRAC 424 Query: 462 VGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIF 507 +G++ A E TL L +L++F E ++D L L P+ + Sbjct: 425 IGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVV 470 >4YZR-A nrPDB Length = 405 Score = 184 bits (467), Expect = 8e-47, Method: Composition-based stats. Identities = 53/337 (15%), Positives = 119/337 (35%), Gaps = 41/337 (12%) Query: 183 HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFH 242 H R++ F E+L + ++ + + A F Sbjct: 99 HTRLRSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPL------PFI 152 Query: 243 TSVPLLNVPPELYRLFRTKTW------RDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRN 296 L+ +P E F+ T + + + + Y D R K + Sbjct: 153 VISELMGIPKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLIHDRRIKPKDDL 212 Query: 297 YPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVL 356 +++ K+ +++ + + ++ G+ TT L + + Sbjct: 213 ISKLVHAEENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQH------------ 260 Query: 357 NARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQ-RYPESDLVLQDYLIPAKTLVQ 415 + + K+ Q ++ +++E LR V + R+ D + + I ++ Sbjct: 261 ------KKECEKLKQQPEMIATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIF 314 Query: 416 VAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFL 475 + I + RDP FF +P+ + R + R++ FG+G+ C+G +A LE + Sbjct: 315 IGIGSANRDPNFFENPEILNINRSPN--------RHISFGFGIHFCLGAPLARLEGHIAF 366 Query: 476 IHILENF-KVEMQHIG-DVDTIFNLILTPDKPIFLVF 510 +L+ F +E+ D+ N+ L + + + Sbjct: 367 KALLKRFPDIELAVAPDDIQWRKNVFLRGLESLPVSL 403 >3R9C-A nrPDB Length = 418 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 74/389 (19%), Positives = 116/389 (29%), Gaps = 86/389 (22%) Query: 129 YHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQ 188 Q P LF + R L ++ AP IK P + + + + Sbjct: 87 TQPRPQGPASFLFLDPPDHTRLR-GLVSKAFAPRVIKRLEPEITALVDQLLDAVD----- 140 Query: 189 QGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLL 248 G +++ P LL Sbjct: 141 ---------------------------GPEFNLIDNLAYPL----------PVAVICRLL 163 Query: 249 NVPPELYRLFR----------------TKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKT 292 VP E F T D Y + RR Sbjct: 164 GVPIEDEPKFSRASALLAAALDPFLALTGETSDLFDEQMKAGMWLRDYLRALIDERRRTP 223 Query: 293 EFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLR 352 G++ +++ +++ A +L G TT + M R+ L Sbjct: 224 GEDLMSGLVAVEESGDQLTEDEIIATCNLLLIAGHETTVNLIANAALAMLRTPGQWAALA 283 Query: 353 EEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKT 412 + A A I+ET+R P + RY DL + + +P Sbjct: 284 ADGSRA------------------SAVIEETMRYDPPVQLVSRYAGDDLTIGTHTVPKGD 325 Query: 413 LVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMT 472 + + + A RDP +PD+FDP R R+LGFG G C+G +A LE T Sbjct: 326 TMLLLLAAAHRDPTIVGAPDRFDPDR--------AQIRHLGFGKGAHFCLGAPLARLEAT 377 Query: 473 LFLIHILENFKVEMQHIGDVDTIFNLILT 501 + L + F E + G+ + NL L Sbjct: 378 VALPALAARFP-EARLSGEPEYKRNLTLR 405 >5FOI-A nrPDB Length = 408 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 75/403 (18%), Positives = 142/403 (35%), Gaps = 52/403 (12%) Query: 123 IPPWLAYHRYYQKPIGVLFKKSGTWKKDR------VVLNTEVMAPEAIKNFIPLLNPVSQ 176 + + + ++ S TW R ++++ V + + + Sbjct: 35 PEQYAEFRQRATLVPAKVWDGSPTWLVSRYEHVRALLVDPRVTVDPTRQPRLSEADGDGD 94 Query: 177 DFVSLL------HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEA 230 F S+L H R+++ F E + + + ++ +RL LE V+ Sbjct: 95 GFRSMLMLDPPEHTRLRRMFISAFSVRQVETMRPEIEKIVDGIL--DRLLALEPPVDILT 152 Query: 231 QKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRR 290 A+ LL VP E F+ ++ D + E +R Sbjct: 153 HL---ALPMSTQVICHLLGVPYEDREFFQERSELASRPNDDRSMPALIELVEYLDGLVRT 209 Query: 291 KTEFRNYPGILYCL----LKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLN 346 KT + G+L L ++ +++ N +LA G T++ + + + R Sbjct: 210 KTAHPD-TGLLGTAVTERLLKGEITHQELVNNAVLLLAAGHETSANQVTLSVLTLLRHPE 268 Query: 347 VQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDY 406 LRE L+ ++ E LR H I+ L+R +D+VL D+ Sbjct: 269 TAAELRE------------------QPELMPNAVDELLRYHSIADGLRRAATADIVLGDH 310 Query: 407 LIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRI 466 I A + + + + D F + FD R ++ FG+G QC+G+ + Sbjct: 311 TIRAGDGLIILLSSANHDGNTFGAEATFDIHR--------PARHHVAFGYGPHQCLGQNL 362 Query: 467 AELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLV 509 A LEM + L + + + L + PIF + Sbjct: 363 ARLEMEVTLGKLFRR----VPALRLAQEPDALRVRQGSPIFGI 401 >6GK6-A nrPDB Length = 411 Score = 183 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 71/387 (18%), Positives = 127/387 (32%), Gaps = 56/387 (14%) Query: 112 KFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPL- 170 + R D+P W+A K R++ + + E + + PL Sbjct: 31 RLHRLVHPRLDVPIWVAVR---------YDDCVELLKDPRLIRDFRKLPDEVRRRYFPLS 81 Query: 171 -----LNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEET 225 ++ D H R++ F + E L E ++ E Sbjct: 82 DRTTFMDQHMLDADPPDHTRLRAIVQRAFSPRMMEGLRPRIQEIADGLIDAVIDRRRMEL 141 Query: 226 VNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFR--------TKTWRDHVAAWDTIFNKA 277 + A AV LL +P E FR R+ V + + Sbjct: 142 IADFAFPLPTAVIA------ELLGLPVEDRGRFRRWTKILLAPAKDREFVERAQPVVEEF 195 Query: 278 EKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWH 337 Y R+ G+L + K+ ++ + + +L G TT + Sbjct: 196 AAYFRALADARRKAPRDDLISGLLLAEEQEHKLSPAELSSMVFLLLVAGHETTVHLIASG 255 Query: 338 LYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLH-PISVTLQRY 396 + + + L E+ L+ ++++E LR P ++ R+ Sbjct: 256 MLLLLSHPAERRRLDED------------------PGLVGSAVEEALRCEGPAELSTIRW 297 Query: 397 PESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGW 456 D+ L +PA V + A RDP F PD+FD R + R++GFG Sbjct: 298 SLEDIELFGARVPAGEGVAAGLLAANRDPQHFPDPDRFDIGRSPN--------RHIGFGG 349 Query: 457 GVRQCVGRRIAELEMTLFLIHILENFK 483 G+ C+G +A +E + +L Sbjct: 350 GIHFCLGAMLARIEAAIAFSTLLRRLP 376 >4GGV-A nrPDB Length = 418 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 63/359 (17%), Positives = 121/359 (33%), Gaps = 49/359 (13%) Query: 138 GVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGD 197 G + + + L + P + + + ++++ + + GK + Sbjct: 93 GDMSQMDPPRHRKYRQLVSRAFTPRLVADMETRVADITRELLDAVD--------GKPEIE 144 Query: 198 IKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRL 257 I DL + + + G G +K+ D + + F Sbjct: 145 IAADLAYPLPVIVIAELLGVPAG-----DRDLFKKWADDIIEGFS------GFSFLDTSG 193 Query: 258 FRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKA 317 + RD + Y + RR ++ + E++ ++ Sbjct: 194 QGEQDVRDATERLRPLL----DYMAGHVTERRRTPREDLLTHLVQAEVDGERLTDNEIVN 249 Query: 318 NITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLK 377 +L G TT+MTL + + V +R L+ Sbjct: 250 VANILLVTGHITTTMTLGNTVLCLDADPEVAAKVR------------------ADRSLVP 291 Query: 378 ASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPT 437 +I+E LR+ S L R ++ + +IP +V + + A RDP F+ P+ +DPT Sbjct: 292 GAIEEALRVLSPSAALARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDPT 351 Query: 438 RWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIF 496 R + + GFG G+ C+G +A LE + L + + F V T F Sbjct: 352 RDPNP--------HFGFGRGIHFCLGAPLARLEGRVALNALFDRFPVLRTDPAKPPTFF 402 >2ZBZ-A nrPDB Length = 412 Score = 181 bits (459), Expect = 6e-46, Method: Composition-based stats. Identities = 72/433 (16%), Positives = 131/433 (30%), Gaps = 80/433 (18%) Query: 86 GPIYREKLG-NLESVYIIHPEDVAHLFKFEGSYPERYD---IPPWLAYHRYYQKPIGVLF 141 GP++R L ++ + E L R D A+ + P + Sbjct: 38 GPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPAFEAVRESPQAFIG 97 Query: 142 KKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKED 201 R + + IK P + V F L + + + V Sbjct: 98 LDPPE-HGTRRRMTISEFTVKRIKGMRPEVEEVVHGF---LDEMLAAGPTADLVSQF--- 150 Query: 202 LFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTK 261 A+ LL VP + F+ Sbjct: 151 ----------------------------------ALPVPSMVICRLLGVPYADHEFFQDA 176 Query: 262 TWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCL----LKSEKMLLEDVKA 317 + R + A + L + + G++ L L + ++ E++ + Sbjct: 177 SKRLVQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGALVADQLANGEIDREELIS 236 Query: 318 NITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLK 377 +L G TT+ + + LR L+ Sbjct: 237 TAMLLLIAGHETTASMTSLSVITLLDHPEQYAALR------------------ADRSLVP 278 Query: 378 ASIKETLRLHPIS-VTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDP 436 +++E LR I+ + R +D+ ++ LI A V V RD + PD D Sbjct: 279 GAVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTVYEDPDALDI 338 Query: 437 TRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIF 496 R +L FG+GV QC+G+ +A LE+ + L +++ + + + Sbjct: 339 HRSA--------RHHLAFGFGVHQCLGQNLARLELEVILNALMDR----VPTLRLAVPVE 386 Query: 497 NLILTPDKPIFLV 509 L+L P I V Sbjct: 387 QLVLRPGTTIQGV 399 >2VZM-A nrPDB Length = 436 Score = 181 bits (458), Expect = 8e-46, Method: Composition-based stats. Identities = 69/380 (18%), Positives = 131/380 (34%), Gaps = 50/380 (13%) Query: 149 KDRVVLNTEVMAPEAIKNFIPLLNPVSQ------DFVSLLHKRIKQQGSGKFVGDIKEDL 202 + R VL + + + PL + + H R+++ + +F E L Sbjct: 80 RARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELL 139 Query: 203 FHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKT 262 E + ++ E+ + + + LL VP FR Sbjct: 140 RPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVIS----ELLGVPEPDRAAFR--V 193 Query: 263 WRDHVAAWDTIFNKAEKYTEI--FYQDLRRKTEFRNYPGILYCLLK-----SEKMLLEDV 315 W D D E+ + L ++ +L L++ ++ E++ Sbjct: 194 WTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEEL 253 Query: 316 KANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPL 375 +L G TT + +Y + + LR + L Sbjct: 254 LGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALR------------------ADMTL 295 Query: 376 LKASIKETLRLH-PISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKF 434 L +++E LR P+ R+P + L +IPA V V + R P F P +F Sbjct: 296 LDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRF 355 Query: 435 DPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILEN---FKVEMQHIGD 491 D R + +L FG G+ C+G +A LE + + +LE +++ G+ Sbjct: 356 DIRRDTAG--------HLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSP-GE 406 Query: 492 VDTIFNLILTPDKPIFLVFR 511 + N ++ K + + +R Sbjct: 407 LVWYPNPMIRGLKALPIRWR 426 >5FYF-A nrPDB Length = 470 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 84/526 (15%), Positives = 172/526 (32%), Gaps = 89/526 (16%) Query: 8 LRSALVKACPPILSTVGEGWGHHRVGTGEGAGISTKTPRP-YSEIPSPG----------- 55 ++S L+ A ++ + G + + + + P P + E P P Sbjct: 11 IQSRLINATSRVVPMQRQIQGLKFLMSAKRKTFGPRRPMPEFVETPIPDVNTLALEDIDV 70 Query: 56 DNGWLNLYHFWRE--KGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPED-VAHLFK 112 N +L WR K + H + +GP + + A Sbjct: 71 SNPFLYRQGQWRAYFKRLRDEAPVHYQKNSPFGPFWSVTRFEDILFVDKSHDLFSAEPQI 130 Query: 113 FEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLN 172 G PE + ++A + V+AP+ +K L+ Sbjct: 131 ILGDPPEGLSVEMFIAMD--------------PPKHDVQRSSVQGVVAPKNLKEMEGLIR 176 Query: 173 PVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQK 232 +G + + D +++ + G L L + E K Sbjct: 177 ----------------SRTGDVLDSLPTDKPFNWVPAVSKELTGRMLATLLDFPYEERHK 220 Query: 233 FIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKT 292 ++ S + F D A +D + A ++ ++ R+ Sbjct: 221 LVE-------WSDRMAGAASATGGEFA-----DENAMFDDAADMARSFSRLWRDKEARRA 268 Query: 293 EFRNYPGILYCLLKSEKMLLE------DVKANITEMLAGGVNTTSMTLQWHLYEMARSLN 346 L LL+S K + + N+T ++ GG +TT ++ L M Sbjct: 269 AGEEPGFDLISLLQSNKETKDLINRPMEFIGNLTLLIVGGNDTTRNSMSGGLVAMNEFP- 327 Query: 347 VQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDY 406 + K+ L+ + E +R ++R + D+ L Sbjct: 328 -----------------REFEKLKAKPELIPNMVSEIIRWQTPLAYMRRIAKQDVELGGQ 370 Query: 407 LIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRI 466 I V + + RD F +PD+F R +++ ++ FG+GV +C+G R+ Sbjct: 371 TIKKGDRVVMWYASGNRDERKFDNPDQFIIDRKDARN-------HMSFGYGVHRCMGNRL 423 Query: 467 AELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRP 512 AEL++ + IL+ F ++ + + + + + + + + P Sbjct: 424 AELQLRILWEEILKRFD-NIEVVEEPERVQSNFVRGYSRLMVKLTP 468 >2Y5N-A nrPDB Length = 417 Score = 180 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 58/311 (18%), Positives = 109/311 (35%), Gaps = 43/311 (13%) Query: 183 HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFH 242 H R+++ F E L A E E + + T P + A Sbjct: 111 HSRLRRLVVKAFTARRAESLRPRAREIA-----HELVDQMAATGQPADLVAMFARQLPVR 165 Query: 243 TSVPLLNVPPELYRLFRTKTWRDHVAAWDTI----FNKAEKYTEIFYQDLRRKTEFRNYP 298 LL VP + F W + + +A + + DL + Sbjct: 166 VICELLGVPSADHDRFTR--WSGAFLSTAEVTAEEMQEAAEQAYAYMGDLIDRRRKEPTD 223 Query: 299 GILYCLLKS----EKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREE 354 ++ L+++ + + +++ +L G +T+ + +Y + ++ L Sbjct: 224 DLVSALVQARDQQDSLSEQELLDLAIGLLVAGYESTTTQIADFVYLLMTRPELRRQL--- 280 Query: 355 VLNARRQAEGDISKMLQMVPLLKASIKETLRLHP--ISVTLQRYPESDLVLQDYLIPAKT 412 L L+ ++++E R P + RY D+ L+ I A Sbjct: 281 ---------------LDRPELIPSAVEELTRWVPLGVGTAFPRYAVEDVTLRGVTIRAGE 325 Query: 413 LVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMT 472 V + A RD A F D+ D R + ++LGFG GV C+G +A +E+ Sbjct: 326 PVLASTGAANRDQAQFPDADRIDVDRTPN--------QHLGFGHGVHHCLGAPLARVELQ 377 Query: 473 LFLIHILENFK 483 + L +L+ Sbjct: 378 VALEVLLQRLP 388 >4JBT-A nrPDB Length = 410 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 77/428 (17%), Positives = 136/428 (31%), Gaps = 79/428 (18%) Query: 86 GPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPI-------- 137 GP+ R L + ++ + L + W + Q P+ Sbjct: 30 GPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDINAWSLWQSGTVTRQWPLIGMIDVDR 89 Query: 138 GVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGD 197 + ++ R+ T+ + + P + + LL + G V Sbjct: 90 SMFTVDGPEHRRLRIKT-TQALTRRRLDALKPTIE---RYVAELLDDLERAGADGAVV-- 143 Query: 198 IKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRL 257 + P + I A L+ VP E Sbjct: 144 ----------------------DLKSVFAYPLPMRVISA----------LMGVPSEDQEQ 171 Query: 258 FRT--KTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTE---FRNYPGILYCLLKSEKMLL 312 T K + + D ++ F + +RRKT ++Y + Sbjct: 172 LLTWYKAFFSILTPQDERLRVIDEMHGYFTEMVRRKTAEPGDDLTSALIYATDGETPLTE 231 Query: 313 EDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQM 372 E+V N+ ++A G TT + + + ++R+ + Sbjct: 232 EEVIGNLQALVAAGHETTVSLILTAVRALLSHPEQLRLVRDGEIG--------------- 276 Query: 373 VPLLKASIKETLRLH-PISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFS-S 430 + +I+ETLR P+ L R+ D+ L D +IP V ++ A+GRD Sbjct: 277 ---WETAIEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVHGAD 333 Query: 431 PDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIG 490 D FD TR + R++ FG G C G +A LE + L + F + Sbjct: 334 ADDFDITRATAA-------RHISFGHGPHICPGAALARLEAAIALPALFTRFP-HLHPAL 385 Query: 491 DVDTIFNL 498 +D I NL Sbjct: 386 PLDQIPNL 393 >6A7I-A nrPDB Length = 411 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 58/323 (17%), Positives = 111/323 (34%), Gaps = 36/323 (11%) Query: 200 EDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFR 259 E L + + E + + GE + + E P I + + P L E + F Sbjct: 120 EALTNASLEKLAALPAGEPVDLKAEFAYPLPMNVISELMGVDAADHPRLKELFE--KFFS 177 Query: 260 TKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANI 319 T+T + V + R ++ + + E++ + Sbjct: 178 TQTPPEEVP---QMMADLGALFTKIVDAKRTNPGDDLTSALIAASENGDHLTDEEIVNTL 234 Query: 320 TEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKAS 379 ++A G TT + + + ++ + + Sbjct: 235 QLIIAAGHETTISLIVNVVEALQTHPEQRKKVLNGEIG------------------WDGV 276 Query: 380 IKETLRLHPI-SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFF-SSPDKFDPT 437 I+ETLR + S L R+ D+ + D ++P + ++ A+GRD + + +FD T Sbjct: 277 IEETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGALGRDEEQYGPTAGEFDAT 336 Query: 438 RWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFN 497 R + R++ FG G C G ++ LE + L + E F + D Sbjct: 337 RTPN--------RHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPASDLRNK 388 Query: 498 LILTPDKPIFLVFR---PFNQDP 517 I+T + L + PF D Sbjct: 389 PIVTQNDLHELPVKLGCPFGGDA 411 >3A50-A nrPDB Length = 411 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 67/367 (18%), Positives = 126/367 (34%), Gaps = 50/367 (13%) Query: 121 YDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVS 180 D P WL + V + S W + R+ + P + L++P Sbjct: 41 PDGPVWLLTRYADVREAFVDPRLSKDW-RHRLPEDQRADMPATPTPMMILMDP------- 92 Query: 181 LLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKM 240 H R+++ F +L E ++ G + + A + Sbjct: 93 PDHTRLRKLVGRSFTVRRMNELEPRITEIADGLLAGLPTDGPVDLMREYAFQI------P 146 Query: 241 FHTSVPLLNVPPELYRLFR--TKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYP 298 LL +P E F + D A D + + DL + Sbjct: 147 VQVICELLGLPAEDRDDFSAWSSVLVDDSPADDKNAAMGK--LHGYLSDLLERKRTEPDD 204 Query: 299 GILYCL-----LKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLRE 353 +L L + +++ E++ A +L G TT + + + + +++L E Sbjct: 205 ALLSSLLAVSDMDGDRLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPDQRKLLAE 264 Query: 354 EVLNARRQAEGDISKMLQMVPLLKASIKETLRLH-PISVTLQRYPESDLVLQDYLIPAKT 412 + L+ ++++E LR P+S R+ D+ IPA Sbjct: 265 D------------------PSLISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGE 306 Query: 413 LVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMT 472 +V + + A RD + PD+ D TR S + FG G+ C+G ++A LE Sbjct: 307 MVMLGLAAANRDADWMPEPDRLDITRDASGG--------VFFGHGIHFCLGAQLARLEGR 358 Query: 473 LFLIHIL 479 + + + Sbjct: 359 VAIGRLF 365 >5CJE-A nrPDB Length = 393 Score = 179 bits (453), Expect = 3e-45, Method: Composition-based stats. Identities = 59/335 (17%), Positives = 105/335 (31%), Gaps = 39/335 (11%) Query: 183 HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFH 242 H R++ + F E L E ++ + V+ A Sbjct: 91 HTRLRSLVARAFTMRRVEALRPRIQEITDGLLDEMLPRGRADLVDSFAYPL------PIT 144 Query: 243 TSVPLLNVPPELYRLFRTKTWRDHVAAWDTI----FNKAEKYTEIFYQDLRRKTEFRNYP 298 LL VP FR + + + Y + D R + Sbjct: 145 VICELLGVPDIDRVTFRALSNEIVAPTGGDAELAAYERLAAYLDELIDDKRSTAPADDLL 204 Query: 299 GILYCLL--KSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVL 356 G L +++ E+++A +L G TT + ++ + + LR Sbjct: 205 GDLIRTRAEDDDRLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALR---- 260 Query: 357 NARRQAEGDISKMLQMVPLLKASIKETLRLH-PISVTLQRYPESDLVLQDYLIPAKTLVQ 415 + LL +++E LR P+ RY + + I V Sbjct: 261 --------------ADMTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPVM 306 Query: 416 VAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFL 475 + + A GRDPA P FD R +L FG G+ C+G +A LE + L Sbjct: 307 IGLDAAGRDPARHPDPHVFDIHRAPQG--------HLAFGHGIHYCLGAPLARLEARVAL 358 Query: 476 IHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVF 510 +LE +++ + + + + Sbjct: 359 RSLLERCPDLALDGPPGARPPGMLIRGVRRLPVRW 393 >5XJN-A nrPDB Length = 455 Score = 178 bits (451), Expect = 6e-45, Method: Composition-based stats. Identities = 53/388 (13%), Positives = 127/388 (32%), Gaps = 63/388 (16%) Query: 100 YIIHPEDVAHLFKFEGSY-------PERYDIPPW--LAYHRYYQKPIGVLFKKSGTWKKD 150 + +D+ F ++ P R P + + G+ + + Sbjct: 87 VVTKYDDIKTTFDDWETFSSENAQAPVRKRGPQATQIMTDGGFTAYSGLSARIPPEHTRI 146 Query: 151 RVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESI 210 R + + P K P + + D V + + + VGD+ DL + Sbjct: 147 R-AIAQKAFTPRRYKALEPDIRAMVIDRVEKM------LANDQHVGDMVSDLAYDIPTIT 199 Query: 211 TNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAW 270 + G + M++ + D+ M + + + + Sbjct: 200 ILTLIGADISMVDTYKR-----WSDSRAAMTWGDL----------------SDEEQIPHA 238 Query: 271 DTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTT 330 + ++ + D ++ + +++ ++ + + +L G TT Sbjct: 239 HNLVEYWQEC-QRMVADAHAHGGDNLTADLVRAQQEGQEITDHEIASLLYSLLFAGHETT 297 Query: 331 SMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPIS 390 + + + + + L+ L+ A++ E LR Sbjct: 298 TTLISNCFRVLLDHPEQWQAI------------------LENPKLIPAAVDEVLRYSGSI 339 Query: 391 VTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFR 450 V +R D + I V + + + RD A F + ++FD +R +++ Sbjct: 340 VGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFDISRANARE------- 392 Query: 451 NLGFGWGVRQCVGRRIAELEMTLFLIHI 478 +L FG+G+ C+G +A+L+ + L + Sbjct: 393 HLSFGFGIHYCLGNMLAKLQAKICLEEV 420 >6HQW-A nrPDB Length = 445 Score = 178 bits (451), Expect = 6e-45, Method: Composition-based stats. Identities = 55/335 (16%), Positives = 132/335 (39%), Gaps = 32/335 (9%) Query: 165 KNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEE 224 + +P+ + + + + + + + +++ ++ + ++ +GER +++ Sbjct: 123 ERQLPMFIAMDRPDHTGQRRTVAPAFTPAKMVEMEAEIRRRTASVLDSLPWGERFDWVDK 182 Query: 225 TVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIF 284 + A+ F + L + T DT F + F Sbjct: 183 VSIELTTGML-AILFGFPWADRRLLTFWSDWAGDVELTL--ARELADTRFGFLGEMAHYF 239 Query: 285 YQDLRRKTEFRNYPGILYCLLKSE---KMLLEDVKANITEMLAGGVNTTSMTLQWHLYEM 341 + + + ++ ++ SE M ++ N+ ++ GG +TT T+ ++ + Sbjct: 240 QRLWGARMQAPPSGDLISMMIHSEAMNHMSPQEFMGNLVLLIVGGNDTTRNTMSGIVHAL 299 Query: 342 ARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDL 401 + + +E+L + L+ +++E +R ++R +D Sbjct: 300 DKFPDQRELLE------------------RDASLIPNAVQECIRYVTPLAHMRRTATADT 341 Query: 402 VLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQC 461 L I A V + + RD F +PDK R ++ R+L FG G+ +C Sbjct: 342 ELFGNQIKAGEKVILWYISANRDETVFENPDKLMVDRPNAR-------RHLSFGHGIHRC 394 Query: 462 VGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIF 496 VG R+AEL++ + L + E ++ ++ G+V+ + Sbjct: 395 VGARLAELQLRILLEEMHER-RMRVRVAGEVERVR 428 >5GWE-A nrPDB Length = 405 Score = 178 bits (450), Expect = 7e-45, Method: Composition-based stats. Identities = 53/388 (13%), Positives = 127/388 (32%), Gaps = 63/388 (16%) Query: 100 YIIHPEDVAHLFKFEGSY-------PERYDIPPW--LAYHRYYQKPIGVLFKKSGTWKKD 150 + +D+ F ++ P R P + + G+ + + Sbjct: 37 VVTKYDDIKTTFDDWETFSSENAQAPVRKRGPQATQIMTDGGFTAYSGLSARIPPEHTRI 96 Query: 151 RVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESI 210 R + + P K P + + D V + + + VGD+ DL + Sbjct: 97 R-AIAQKAFTPRRYKALEPDIRAMVIDRVEKM------LANDQHVGDMVSDLAYDIPTIT 149 Query: 211 TNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAW 270 + G + M++ + D+ M + + + + Sbjct: 150 ILTLIGADISMVDTYKR-----WSDSRAAMTWGDL----------------SDEEQIPHA 188 Query: 271 DTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTT 330 + ++ + D ++ + +++ ++ + + +L G TT Sbjct: 189 HNLVEYWQEC-QRMVADAHAHGGDNLTADLVRAQQEGQEITDHEIASLLYSLLFAGHETT 247 Query: 331 SMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPIS 390 + + + + + L+ L+ A++ E LR Sbjct: 248 TTLISNCFRVLLDHPEQWQAI------------------LENPKLIPAAVDEVLRYSGSI 289 Query: 391 VTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFR 450 V +R D + I V + + + RD A F + ++FD +R +++ Sbjct: 290 VGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFDISRANARE------- 342 Query: 451 NLGFGWGVRQCVGRRIAELEMTLFLIHI 478 +L FG+G+ C+G +A+L+ + L + Sbjct: 343 HLSFGFGIHYCLGNMLAKLQAKICLEEV 370 >4UBS-A nrPDB Length = 393 Score = 178 bits (450), Expect = 7e-45, Method: Composition-based stats. Identities = 71/405 (17%), Positives = 127/405 (31%), Gaps = 75/405 (18%) Query: 87 PIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRY----YQKPIGVLFK 142 P+ R L + SV+++ A + +P + A + + +L Sbjct: 27 PLSRVSLYDGRSVWVVTGHAAARALLSDQRLSSDRTLPRFPATTERFEAVRTRRVALLGV 86 Query: 143 KSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDL 202 + R +L A L P Q+ V L ++ QG + Sbjct: 87 DDPEHRTQRRMLVPSFTLKRA-----AALRPRIQETVDGLLDAMEAQGPPAELVS----- 136 Query: 203 FHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKT 262 A+ LL VP + F +++ Sbjct: 137 -------------------------------AFALPLPSMVICALLGVPYADHDFFESQS 165 Query: 263 WR----DHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKAN 318 R +A + + Y R++ ++ L + ++ + Sbjct: 166 RRLLRGPGIAEVQDARAQLDDYLYALIDRKRKEPGDGLLDDLIQEQLNRGTVDRAELVSL 225 Query: 319 ITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKA 378 T +L G TT+ + + + R LR E L+ A Sbjct: 226 ATLLLIAGHETTANMISLGTFTLLRHPEQLAELRAE------------------PGLMPA 267 Query: 379 SIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTR 438 +++E LR I+ L R D+ + I A V A + RD A F+ PD D R Sbjct: 268 AVEELLRFLSIADGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHR 327 Query: 439 WLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 ++ FG+G+ QC+G+ +A EM + L + E Sbjct: 328 SA--------RHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLP 364 >5XNT-A nrPDB Length = 411 Score = 178 bits (450), Expect = 8e-45, Method: Composition-based stats. Identities = 59/345 (17%), Positives = 108/345 (31%), Gaps = 56/345 (16%) Query: 140 LFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIK 199 + + + R L P +++N+ P + ++ + + + + + V + Sbjct: 88 ITEADPPEHRKRRSLLAAAFTPRSLQNWEPRIQEIADELIEEMDEETEI----DIVQSLA 143 Query: 200 EDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFR 259 L + V +RL +F V +L +P F Sbjct: 144 SPLPIIVMSDLMGVPSKDRL--------------------LFKKWVDILFLP------FD 177 Query: 260 TKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANI 319 + + + +Y R +L + E ++V Sbjct: 178 KEKQEEVNELKQVAAKEYYQYLYPIVVQKRLNPADDIISDLLKAEVDGEMFTDDEVVRTT 237 Query: 320 TEMLAGGVNTTSMTLQWHLYEMA-RSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKA 378 +L GV TTS L Y + V + L E + L+ Sbjct: 238 MLILGAGVETTSHLLANSFYSLLYDDKEVYQELHE------------------NLDLVPQ 279 Query: 379 SIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTR 438 +++E LR + L R + D L + V V + A D F + R Sbjct: 280 AVEEMLRYRFNLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMFEDAFTLNIHR 339 Query: 439 WLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 +K ++L FG G C+G +A LE + L L+ FK Sbjct: 340 PNNK-------KHLTFGNGPHFCLGAPLARLEAKIALTTFLKKFK 377 >1UED-A nrPDB Length = 406 Score = 177 bits (449), Expect = 9e-45, Method: Composition-based stats. Identities = 71/426 (16%), Positives = 129/426 (30%), Gaps = 80/426 (18%) Query: 71 SQRIHFRHIENF--QKYGPIYRE------KLGNLESVYIIHPEDVAHLFKFEGSYPERYD 122 + H +NF + +GP+ R +LG E V + + R Sbjct: 20 LRTNCDPHEDNFGLRAHGPLVRIVGESSTQLGRDFVWQAHGYEVVRRILGDHEHFTTRPQ 79 Query: 123 IPPWLAYHRYYQKPIGVLFK-KSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSL 181 + + +G + + R +L E I+ P Sbjct: 80 FTQSKSGAHVEAQFVGQISTYDPPEHTRLRKMLTPE-FTVRRIRRMEP------------ 126 Query: 182 LHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMF 241 + +RL +LE + + A Sbjct: 127 ----------------------------AIQSLIDDRLDLLEAEGPSADLQGLFADPVGA 158 Query: 242 HTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAE-KYTEIFYQDLRRKTEFRNYPGI 300 H LL +P + R F + R+ + A+ + +L + G+ Sbjct: 159 HALCELLGIPRDDQREFVRRIRRNADLSRGLKARAADSAAFNRYLDNLLARQRADPDDGL 218 Query: 301 LYCLLKS--EKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNA 358 L +++ + + E++K T ++ GGV T + + + + + + E+L E A Sbjct: 219 LGMIVRDHGDNVTDEELKGLCTALILGGVETVAGMIGFGVLALLDNPGQIELLFESPEKA 278 Query: 359 RRQAEGDISKMLQMVPLLKASIKETLRLHPISVTL-QRYPESDLVLQDYLIPAKTLVQVA 417 + + E +R R D+V+ LI A V + Sbjct: 279 ------------------ERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCS 320 Query: 418 IYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIH 477 I RD A PD D R D +GFG G+ CVG +A + + Sbjct: 321 ILMANRDEALTPDPDVLDANRAAVSD--------VGFGHGIHYCVGAALARSMLRMAYQT 372 Query: 478 ILENFK 483 + F Sbjct: 373 LWRRFP 378 >6GMF-A nrPDB Length = 397 Score = 176 bits (447), Expect = 2e-44, Method: Composition-based stats. Identities = 64/366 (17%), Positives = 119/366 (32%), Gaps = 60/366 (16%) Query: 151 RVVLNTEVMAPEAIKNFIP-------LLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLF 203 RV+ + + + +P + P H +++ + F L Sbjct: 48 RVLHDAKGFSNRGWAASLPRGVKWDTSMPPSIVQVDPPRHGKLRTLVTKAFTPRTVAQLE 107 Query: 204 HFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTW 263 + ++ G R E V +L V PE R K W Sbjct: 108 PRIRDIAHELVDGLRGKSTFEATVE------VTVPMPMIVIAEMLGVAPE--RRADFKRW 159 Query: 264 RDHV------------AAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKML 311 D + A + + Y ++ RR+ +L + EK+ Sbjct: 160 SDDMVGSLALVRVGNAAQLERSTQEFYAYFSEVLEERRREPREDLISQLLAAEVDGEKLT 219 Query: 312 LEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQ 371 +V + +L G TT+ + L + + Sbjct: 220 AGEVLSFANTLLIAGNETTTSLIGNALVALTDHPEQLAAAQ------------------A 261 Query: 372 MVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSP 431 + L+ A ++E LR + + R +D+ + D IPA+++V + + RD + F P Sbjct: 262 DLSLVPAVVEEVLRYESPAQCIFRQTMTDVEIGDERIPARSVVLPLLASANRDESRFPDP 321 Query: 432 DKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGD 491 D+FD R +L FG + C+G +A LE + L +L +GD Sbjct: 322 DRFDIHRDTKG--------HLAFGLDIHFCIGAPLARLEAKVMLEVLLAR-------LGD 366 Query: 492 VDTIFN 497 + + Sbjct: 367 IQRVSQ 372 >2FR7-A nrPDB Length = 412 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 73/473 (15%), Positives = 158/473 (33%), Gaps = 65/473 (13%) Query: 41 STKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVY 100 + + P + PS G +L + E ++ GP+ L Sbjct: 3 TAPSLVPVTT-PSQHGAGVPHLGIDPFALDYFADPYPEQETLREAGPV--VYLDKWNVYG 59 Query: 101 IIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMA 160 + +V + ++ + +P ++ + + ++V++ Sbjct: 60 VARYAEVYAVLNDPLTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRTRAVLSKVLS 119 Query: 161 PEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLG 220 P +K L + + + + + + + G+ + D+ E +F + +G Sbjct: 120 PATMKR---LRDGFAAAADAKIDELLARGGNIDAIADLAEAYPL--------SVFPDAMG 168 Query: 221 MLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKY 280 + +E + V+ F P EL + ++ + Sbjct: 169 LKQEG-RENLLPYAGLVFNAF-------GPPNELR---------------QSAIERSAPH 205 Query: 281 TEIFYQDLRRKTEFRNYPG-ILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLY 339 + +R G ++ + ++ E+ + +L+ G++TT + +Y Sbjct: 206 QAYVAEQCQRPNLAPGGFGACIHAFSDTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVY 265 Query: 340 EMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPES 399 +AR + LR L + + +E +R T R Sbjct: 266 CLARFPDEFARLR------------------ADPSLARNAFEEAVRFESPVQTFFRTTTR 307 Query: 400 DLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVR 459 D+ L I V + + + RDP + PD++D TR S ++GFG GV Sbjct: 308 DVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRYDITRKTSG--------HVGFGSGVH 359 Query: 460 QCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRP 512 CVG+ +A LE + L + ++ G + FN L + + + P Sbjct: 360 MCVGQLVARLEGEVVLAALARKVAA-IEIAGPLKRRFNNTLRGLESLPIQLTP 411 >5Y1I-A nrPDB Length = 403 Score = 175 bits (442), Expect = 5e-44, Method: Composition-based stats. Identities = 55/322 (17%), Positives = 110/322 (34%), Gaps = 34/322 (10%) Query: 166 NFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEET 225 F+ + P H RI++ + F E + + ++ G G Sbjct: 79 KFLSMAQPSFAGQDDPEHGRIRRMVTLPFTARRIEAMRPAIQKITDELIDGMLAG----- 133 Query: 226 VNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRD-HVAAWDTIFNKAEKYTEIF 284 P A+ +L VP E + + KA ++ Sbjct: 134 PKPVDLVEALALPVPVRVICEMLGVPYEDREFLQQNNNAMIYRDTAQGDAQKAAIAQAMY 193 Query: 285 YQDLRRKTEFRNYPGILYCL---LKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEM 341 ++L IL L +++ ++ +D +L G TT+ + + Sbjct: 194 LKELVGTKLGDRGDDILSDLAVQVEAGEITQDDAAGIGMMLLGAGHETTANMIALGTLAL 253 Query: 342 ARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISV-TLQRYPESD 400 + +R+ ++ +++E LR I+ T++R D Sbjct: 254 LENPEQLAEVRDS----------------DDPKVIVNTVEELLRYLTIAQDTVRRIAAED 297 Query: 401 LVLQDYLIPAKTLVQVAIYAMGRDPAFFSS-PDKFDPTRWLSKDKDLIHFRNLGFGWGVR 459 + + +I A + + A DP + PD+ D R ++ R+L FG+GV Sbjct: 298 IEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDIHRANAR-------RHLAFGYGVH 350 Query: 460 QCVGRRIAELEMTLFLIHILEN 481 QC+G +A +E+ + +L Sbjct: 351 QCLGATLARVELQIVYSTLLRR 372 >4WPZ-A nrPDB Length = 397 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 62/355 (17%), Positives = 120/355 (33%), Gaps = 46/355 (12%) Query: 169 PLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNP 228 L+N + H R+++ + F E L E + G+ L LE P Sbjct: 76 KLMNESLVGMDAPEHTRLRKLVTKAFTARRVETLRPRITE-----LVGQLLDELETLPRP 130 Query: 229 EAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAA-WDTIFNKAE------KYT 281 +V LL VP F W + + W + K Y Sbjct: 131 VDLVKNFSVPLPVRVICELLGVPAGDQDTFHA--WSNALLGDWQQVVEKEAATVSLVNYF 188 Query: 282 EIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEM 341 R ++ + ++ A +L+ G TT+ + L + Sbjct: 189 GELIAVKRENPADDLISELIAISDGDSTLTEREIIALSIGILSAGHETTANQISMFLVTL 248 Query: 342 ARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVT---LQRYPE 398 + + LR+ + ++ E LR P++ T + R Sbjct: 249 LHNPEELDKLRD------------------NREAIPKAVDELLRFVPLTTTGGIIPRLTT 290 Query: 399 SDLVL-QDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWG 457 +++ L ++PA +V A+ RDP F ++ + TR + +L FG G Sbjct: 291 AEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLNVTRENNP--------HLAFGAG 342 Query: 458 VRQCVGRRIAELEMTLFLIHILENFK-VEMQHIGDVDTIFNL-ILTPDKPIFLVF 510 + C+G ++A +E+ L IL+ V + + + I+ + + + + Sbjct: 343 IHHCLGAQLARIELQEALGAILDRMPQVRLAVPESELRLKSASIIRGLESLPITW 397 >3MGX-A nrPDB Length = 415 Score = 173 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 63/307 (20%), Positives = 113/307 (36%), Gaps = 42/307 (13%) Query: 180 SLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYK 239 L K + S + E + + + V+ GE + P Sbjct: 115 RKLRKLVGPLLSRAAARKLAERVRIEVGDVLGRVLDGEVCDA-ATAIGPRI--------- 164 Query: 240 MFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKA---EKYTEIFYQDLRRKTEFRN 296 +L VP E + T D +F+ + +TEI T R Sbjct: 165 PAAVVCEILGVPAEDEDMLIDLTN-HAFGGEDELFDGMTPRQAHTEILVYFDELITARRK 223 Query: 297 YPG--ILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREE 354 PG ++ L+ + + ++DV N +L GG TT + ++ +A + LR+ Sbjct: 224 EPGDDLVSTLVTDDDLTIDDVLLNCDNVLIGGNETTRHAITGAVHALATVPGLLTALRDG 283 Query: 355 VLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLV 414 + ++E LR ++ + R +D+ + +P+ T V Sbjct: 284 SADV------------------DTVVEEVLRWTSPAMHVLRVTTADVTINGRDLPSGTPV 325 Query: 415 QVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLF 474 + A RDPA F PD F P R + R++ FG G+ C+G +A +E+++ Sbjct: 326 VAWLPAANRDPAEFDDPDTFLPGRKPN--------RHITFGHGMHHCLGSALARIELSVV 377 Query: 475 LIHILEN 481 L + E Sbjct: 378 LRVLAER 384 >2Z36-A nrPDB Length = 413 Score = 173 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 53/353 (15%), Positives = 109/353 (30%), Gaps = 48/353 (13%) Query: 147 WKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLL-------------HKRIKQQGSGK 193 ++ R VL + + K+ PL + L H ++ G+ Sbjct: 54 HEEARAVLADGRFSSDKRKDGFPLFTLDAATLQQLRSQPPLMLGMDGAEHSAARRPVIGE 113 Query: 194 FVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPE 253 F L + + + + ML P ++ LL VP Sbjct: 114 FTVKRLAALRPRIQDIVDHFID----DMLATDQRPVDLVQALSLPVPSLVICELLGVPYT 169 Query: 254 LYRLFRTKTW----RDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEK 309 + F+++T R + F + Y + + + + + Sbjct: 170 DHDFFQSRTTMMVSRTSMEDRRRAFAELRAYIDDLITRKESEPGDDLFSRQIARQRQEGT 229 Query: 310 MLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKM 369 + + + +L G TT+ + + + ++ + Sbjct: 230 LDHAGLVSLAFLLLTAGHETTANMISLGVVGLLSHPE------------------QLTVV 271 Query: 370 LQMVPLLKASIKETLRLHPISVTLQ-RYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFF 428 +++E LR I+ + R D+ + I A V V++ + DPA F Sbjct: 272 KANPGRTPMAVEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVF 331 Query: 429 SSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILEN 481 P D R +L FG+G QC+G+ +A +E+ + + Sbjct: 332 KDPAVLDVER--------GARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRR 376 >4YT3-A nrPDB Length = 410 Score = 172 bits (435), Expect = 4e-43, Method: Composition-based stats. Identities = 62/341 (18%), Positives = 107/341 (31%), Gaps = 64/341 (18%) Query: 148 KKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAF 207 + R L P +++N+ P + ++ + + + V + L Sbjct: 96 HRKRRSLLAAAFTPRSLQNWEPRIQEIADELIGQMD----GGTEIDIVASLASPLPIIVM 151 Query: 208 ESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHV 267 + V +RL +K++D ++ F R+ Sbjct: 152 ADLMGVPSKDRL---------LFKKWVDTLFLPF---------------------DREKQ 181 Query: 268 AAWDTIFNKAEK----YTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEML 323 D + A K Y R +L + E ++V +L Sbjct: 182 EEVDKLKQVAAKEYYQYLYPIVVQKRLNPADDIISDLLKSEVDGEMFTDDEVVRTTMLIL 241 Query: 324 AGGVNTTSMTLQWHLYEMA-RSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKE 382 GV TTS L Y + V + L E + L+ +++E Sbjct: 242 GAGVETTSHLLANSFYSLLYDDKEVYQELHE------------------NLDLVPQAVEE 283 Query: 383 TLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSK 442 LR + L R + D L + V V + A D F P + R +K Sbjct: 284 MLRFRFNLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHRPNNK 343 Query: 443 DKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 ++L FG G C+G +A LE + L L+ FK Sbjct: 344 -------KHLTFGNGPHFCLGAPLARLEAKIALTAFLKKFK 377 >6HQG-A nrPDB Length = 425 Score = 171 bits (433), Expect = 6e-43, Method: Composition-based stats. Identities = 57/313 (18%), Positives = 108/313 (34%), Gaps = 48/313 (15%) Query: 222 LEETVNPEAQKFIDAVYKMFHTSV--PLLNVPPELYRLFRTKTWRDHVAAWDTI------ 273 L++ E ++D V T L + P E R W D + Sbjct: 141 LDDLPIGEEINWVDKVSIELTTMTLATLFDFPWEDRRKLTF--WSDVATSAPESGILGTT 198 Query: 274 ---------FNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSE---KMLLEDVKANITE 321 + + F + + P ++ L E M + N+ Sbjct: 199 DPEEHENLRRQTLFECVDYFMRLWNERVNAPPKPDLISMLAHGESTKNMDRMEYLGNLIL 258 Query: 322 MLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIK 381 ++ GG +TT T+ + + ++ + LRE L+ A + Sbjct: 259 LIVGGNDTTRNTISGSVLALHQNPDQDRKLRE------------------NPGLIPAMVS 300 Query: 382 ETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLS 441 ET+R ++R + D L I V + + RD P+ + R Sbjct: 301 ETIRWQTPLAYMRRRAKRDFELGGKTIREGDKVAMWYVSGNRDEEVIDRPNDYWIER--- 357 Query: 442 KDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILT 501 ++L FG+GV +CVG R+AEL++ + IL F ++ +G +++ + Sbjct: 358 ----PRVRQHLSFGFGVHRCVGNRLAELQLKIIWEEILARFP-RLEVVGPPRRVYSSFVK 412 Query: 502 PDKPIFLVFRPFN 514 + + +V N Sbjct: 413 GYEELPVVIPTRN 425 >5XW2-A nrPDB Length = 419 Score = 171 bits (433), Expect = 7e-43, Method: Composition-based stats. Identities = 57/396 (14%), Positives = 127/396 (32%), Gaps = 52/396 (13%) Query: 101 IIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMA 160 + + + G++ + + + G L + ++ L + Sbjct: 57 VYGYAEAIEVLGDPGTFSSHMSRLLPMGADEAFTE--GDLLQTDPPDHRELRKLVSHAFT 114 Query: 161 PEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLG 220 P+ + P + ++Q+ + + R D+ L + ++ + Sbjct: 115 PKVVAELEPRITALTQELLDAVADR--------DTFDLMTALAYPLPVTVVAELLSIP-- 164 Query: 221 MLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKY 280 + ++ + V + + P + R+F A K +Y Sbjct: 165 ---SADRHLFEGWMTEIVHSL-GDVSMEDAPEDQERIF---------EAGMAPMRKMLEY 211 Query: 281 TEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYE 340 + RR+ ++ + ++ + +L G TT+M + + Sbjct: 212 LREHAAECRRRPRGDLMGKLIEAEVDGRRLTDNHIVNFAKMLLIAGYLTTTMLIGNTVLC 271 Query: 341 MARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESD 400 + +R L+ ++E++R R D Sbjct: 272 LDSYPEQAARVR------------------ADRSLIPGLLEESMRFLSPVAATYRATTRD 313 Query: 401 LVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQ 460 + + + A +V V A RD F+ P+ FD TR + +LGFG G+ Sbjct: 314 VEVAGQRLSADQMVMVWFGAANRDARQFAEPELFDMTRGPNP--------HLGFGRGIHF 365 Query: 461 CVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIF 496 C+G +A +E + L H+L+ F E+ + F Sbjct: 366 CLGGPLARMEGRVALDHLLDRFP-ELYTDPERPPTF 400 >2RFC-A nrPDB Length = 343 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 54/251 (21%), Positives = 95/251 (37%), Gaps = 35/251 (13%) Query: 236 AVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAA--WDTIFNKAEKYTEIFYQDLRRKTE 293 AV + +L +P LF K W D++ D FN ++ + Sbjct: 99 AVRLPVNIISKILGIPDSDMPLF--KLWSDYIIGNKRDENFNYVNNRMVSRLLEIFKSDS 156 Query: 294 FRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLRE 353 + LK+ K+ +++ I ++ GG TT+ + + + + ++ Sbjct: 157 HGIINVLAGSSLKNRKLTMDEKIKYIMLLIIGGNETTTNLIGNMIRVIDENPDI------ 210 Query: 354 EVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQ-RYPESDLVLQDYLIPAKT 412 + +A + G ++ETLR + L R+ D + + I Sbjct: 211 -IDDALKNRSG--------------FVEETLRYYSPIQFLPHRFAAEDSYINNKKIKKGD 255 Query: 413 LVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMT 472 V V + + RD FF PD F R +L FG G+ C+G +A LE + Sbjct: 256 QVIVYLGSANRDETFFDEPDLFKIGR---------REMHLAFGIGIHMCLGAPLARLEAS 306 Query: 473 LFLIHILENFK 483 + L IL +FK Sbjct: 307 IALNDILNHFK 317 >5LIE-A nrPDB Length = 414 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 60/329 (18%), Positives = 105/329 (31%), Gaps = 46/329 (13%) Query: 168 IPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVN 227 +P+ V H RI++ S + + ++ G G + V Sbjct: 88 LPVAGQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGAPFDFVV 147 Query: 228 PEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTW-----RDHVAAWDTIFNKAEKYTE 282 A + LL VP R A N + + Sbjct: 148 EIAAEL------PMQMICILLGVPETDRHWLFEAVEPGFDFRGSRRATMPRLNVEDAGSR 201 Query: 283 IFYQDLR-----RKTEFRNYPGILYCLLKSEK----MLLEDVKANITEMLAGGVNTTSMT 333 ++ L R + ++ + + ++ + + G TT + Sbjct: 202 LYTYALELIAGKRAEPADDMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNS 261 Query: 334 LQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTL 393 + L +A + + + LR LL +I+E +R S + Sbjct: 262 IAGGLLALAENPDQLQTLR------------------SDFELLPTAIEEIVRWTSPSPSK 303 Query: 394 QRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLG 453 +R + L I A V V + RDP+ F D+FD TR + +LG Sbjct: 304 RRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITRKPNP--------HLG 355 Query: 454 FGWGVRQCVGRRIAELEMTLFLIHILENF 482 FG GV C+G +A LE+ + +L F Sbjct: 356 FGQGVHYCLGANLARLELRVLFEELLSRF 384 >3ABB-A nrPDB Length = 408 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 53/308 (17%), Positives = 100/308 (32%), Gaps = 35/308 (11%) Query: 178 FVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAV 237 +H R ++ F + + ++ ML + + A+ Sbjct: 97 VDDPVHARQRRMLIPSFGVKRMNAIRPRLQSLVDRLLD----DMLAKGPGADLVS-AFAL 151 Query: 238 YKMFHTSVPLLNVPPELYRLFRTKTW----RDHVAAWDTIFNKAEKYTEIFYQDLRRKTE 293 LL VP + F + A D F + Y + + E Sbjct: 152 PVPSVAICELLGVPYGDHDFFEECSRNFVGAATSAEADAAFGELYTYLHGLVGRKQAEPE 211 Query: 294 FRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLRE 353 ++ L+ + ++V +L G TT + + + Sbjct: 212 DGLLDELIARQLEEGDLDHDEVVMIALVLLVAGHETTVNAIALGALTLIQHPE------- 264 Query: 354 EVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTL 413 I +L+ + ++E LR +S + R + D+ + I A Sbjct: 265 -----------QIDVLLRDPGAVSGVVEELLRFTSVSDHIVRMAKEDIEVGGATIKAGDA 313 Query: 414 VQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTL 473 V V+I M RD + +PD FD R ++GFG G+ QC+G+ +A E+ + Sbjct: 314 VLVSITLMNRDAKAYENPDIFDARR--------NARHHVGFGHGIHQCLGQNLARAELEI 365 Query: 474 FLIHILEN 481 L + Sbjct: 366 ALGGLFAR 373 >1UE8-A nrPDB Length = 367 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 61/309 (19%), Positives = 111/309 (35%), Gaps = 40/309 (12%) Query: 185 RIKQQGSGKFVGDIKEDLFHFAFESITNVMFGER---LGMLEETVNPEAQKFIDAVYKMF 241 R S + D +L AF + R + +L E A+ Sbjct: 65 RYTMLTSDPPLHDELRNLTADAFNPSNLPVDFVREVTVKLLSELDEEFDVIESFAIPLPI 124 Query: 242 HTSVPLLNVPPELYRLFRTKTWRDHVA----AWDTIFNKAEKYTEIF-YQDLRRKTEFRN 296 +L + P++ ++ K W D VA D IF+ KY E+ + + Sbjct: 125 LVISKMLGINPDVKKV---KDWSDLVALRLGRADEIFSIGRKYLELISFSKKELDSRKGK 181 Query: 297 YPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVL 356 L + + + + + ++ G TT+ + + + N + +RE+ Sbjct: 182 EIVDLTGKIANSNLSELEKEGYFILLMIAGNETTTNLIGNAIEDFTLY-NSWDYVREKGA 240 Query: 357 NARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQV 416 +++E LR P + R + + ++D +I LV+V Sbjct: 241 LK--------------------AVEEALRFSPPVMRTIRVTKEKVKIRDQVIDEGELVRV 280 Query: 417 AIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLI 476 I + RD F PD F P R + +L FG G+ C+G +A LE + L Sbjct: 281 WIASANRDEEVFKDPDSFIPDRTPNP--------HLSFGSGIHLCLGAPLARLEARIALE 332 Query: 477 HILENFKVE 485 + F+V+ Sbjct: 333 EFAKKFRVK 341 >5EX6-C nrPDB Length = 434 Score = 169 bits (428), Expect = 3e-42, Method: Composition-based stats. Identities = 58/339 (17%), Positives = 118/339 (34%), Gaps = 38/339 (11%) Query: 150 DRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFES 209 R + + + + L+ + D+ H R+++ + F + + + Sbjct: 100 RRRFDRNDEIGGKGVFRPRELVGNLM-DYDPPEHTRLRRLLAPGFTHRKIRRMAPYIEQI 158 Query: 210 ITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWR--DHV 267 +T ERL +E +P + A LL VP + +F R D Sbjct: 159 VT-----ERLDEMEREGSPADLIELFADEVPGPVLCELLGVPRDDRAMFLQLCHRHLDAS 213 Query: 268 AAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLL--KSEKMLLEDVKANITEMLAG 325 + E ++ + R+ + G++ ++ + + E+++ +M+ Sbjct: 214 LSGRRRAAAGEAFSRYLVTMVARERKDPG-DGLIGMVVAEHGDTVTDEELRGVCVQMMLA 272 Query: 326 GVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLR 385 G + S + + + R+ LR +V P + ++ E +R Sbjct: 273 GDDNISGMIGLGVLALLRNPEQIAALRGDV------------------PAAERAVDELIR 314 Query: 386 LHPISVT-LQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDK 444 + R D + D +I A V ++ RDPA D+ D TR Sbjct: 315 YLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADRLDVTREAVP-- 372 Query: 445 DLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 ++ FG GV C+G +A LE+ + + F Sbjct: 373 ------HVAFGHGVHHCLGAALARLELRIAYTALWRRFP 405 >3P3Z-A nrPDB Length = 416 Score = 169 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 64/381 (16%), Positives = 128/381 (33%), Gaps = 53/381 (13%) Query: 150 DRVVLNTEVMAP-EAIKNFIPLLNPVSQDFVS--------LLHKRIKQQGSGKFVGDIKE 200 D++ + +++ + + + +DF+ H+R++ + F Sbjct: 66 DQLARDKRLISGFRGLVDMVGTPEGPVRDFMVDFLQSLDGADHRRLRGLATHPFTPRRIT 125 Query: 201 DLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELY----R 256 + F ++ ++ L + Q F + + LL P E Y R Sbjct: 126 AVQPFVRSTVEQLI-----DKLPQGDFDFVQHFPHPLPAL--VMCQLLGFPLEDYDTVGR 178 Query: 257 LFRTKTWRDHVAAWDTIFNKAEKYTEIFYQ------DLRRKTEFRNYPGILYCLLKSEKM 310 L ++ I K E+ + + R+ + + + Sbjct: 179 LSIETNLGLALSNDQDILVKVEQGLGRMFDYLVAAIEKRKVEPGDDLTSDIVRAFHDGVL 238 Query: 311 LLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKML 370 +++ + +L G TT+ L +Y+ A+ + ++E Sbjct: 239 DDYELRTLVATVLVAGYETTNHQLALAMYDFAQHPDQWMKIKE----------------- 281 Query: 371 QMVPLLKASIKETLRLHP-ISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFS 429 L +++E LR P + VT R D + IP T V + + RDP F+ Sbjct: 282 -NPELAPQAVEEVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFA 340 Query: 430 SPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHI 489 D+FD T ++ FG G C+G +A LE+T + + Q Sbjct: 341 DADRFDIT-------VKREAPSIAFGGGPHFCLGTALARLELTEAVAALATRLD-PPQIA 392 Query: 490 GDVDTIFNLILTPDKPIFLVF 510 G++ L + + L F Sbjct: 393 GEITWRHELGVAGPDALPLRF 413 >1Z8P-A nrPDB Length = 404 Score = 168 bits (426), Expect = 5e-42, Method: Composition-based stats. Identities = 55/308 (17%), Positives = 107/308 (34%), Gaps = 39/308 (12%) Query: 183 HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFH 242 H R+++ S +F E + + ++ + + V+ A Sbjct: 98 HTRLRKLVSQEFTVRRVEAMRPRVEQITAELLDEVGDSGVVDIVDRFAHPL------PIK 151 Query: 243 TSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEI--FYQDLRRKTEFRNYPGI 300 LL V + F + V + + + E+ F DL + + Sbjct: 152 VICELLGVDEKYRGEFGRWSSEILVMDPERAEQRGQAAREVVNFILDLVERRRTEPGDDL 211 Query: 301 LYCLLK-----SEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEV 355 L L++ ++ +++ + +L G ++ + Y + + ++R Sbjct: 212 LSALIRVQDDDDGRLSADELTSIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVR--- 268 Query: 356 LNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQ 415 + L +++E LR T R+ ++ + IP + V Sbjct: 269 ---------------RDPSALPNAVEEILRYIAPPETTTRFAAEEVEIGGVAIPQYSTVL 313 Query: 416 VAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFL 475 VA A RDP F P +FD TR +L FG G+ C+GR +A+LE + L Sbjct: 314 VANGAANRDPKQFPDPHRFDVTRDTRG--------HLSFGQGIHFCMGRPLAKLEGEVAL 365 Query: 476 IHILENFK 483 + F Sbjct: 366 RALFGRFP 373 >4TRI-A nrPDB Length = 407 Score = 168 bits (424), Expect = 8e-42, Method: Composition-based stats. Identities = 66/427 (15%), Positives = 134/427 (31%), Gaps = 67/427 (15%) Query: 87 PIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGT 146 P++R++ G + V + + I P P + Sbjct: 35 PVFRDRNGLA---AATTYQAVLDAERNPELFSSTGGIRP-----DQPGMPYMIDMDDPQ- 85 Query: 147 WKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFA 206 R L + + + + + + + + +R G FV DI L Sbjct: 86 -HLLRRKLVNAGFTRKRVMDKVDSIGRLCDTLIDAVCER----GECDFVRDIAAPLPMAV 140 Query: 207 FESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDH 266 G+ LG+L + + D V + Sbjct: 141 I--------GDMLGVLPTERDMLLKWSDDLVCGLSSHVDE------------------AA 174 Query: 267 VAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGG 326 + F ++T+ R + + ++ ++ ++M +++ +L GG Sbjct: 175 IQKLMDTFAAYTEFTKDVITKRRAEPTDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGG 234 Query: 327 VNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRL 386 TT TL ++ R + + L +V LL +I+E LR Sbjct: 235 DETTRHTLSGGTEQLLRHRDQWDALVADVD------------------LLPGAIEEMLRW 276 Query: 387 HPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDL 446 + R +D V + A + + + D + F PD F R + Sbjct: 277 TSPVKNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDRNPN----- 331 Query: 447 IHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF-KVEMQHIGDVDTIFNLILTPDKP 505 ++ FG+G C+G ++A LE+ L +L + + V ++ + Sbjct: 332 ---SHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPES 388 Query: 506 IFLVFRP 512 + +VF P Sbjct: 389 MPVVFTP 395 >2WIO-A nrPDB Length = 431 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 63/360 (17%), Positives = 109/360 (30%), Gaps = 56/360 (15%) Query: 145 GTWKKDRVVLNTEVMAPEAIKNFIPLL--------NPVSQDFVSLLHKRIKQQGSGKFVG 196 G W R V+ A + P + + H+ +++ S F Sbjct: 69 GVWHVFRHADVQTVLRDTATFSSDPTRVIEGASPTPGMIHEIDPPEHRALRKVVSSAFTP 128 Query: 197 DIKEDLFHFAFESITNVMF--GERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPEL 254 DL + +++ GE +++ P LL +PP Sbjct: 129 RTISDLEPRIRDVTRSLLADAGESFDLVDVLAFPL----------PVTIVAELLGLPPMD 178 Query: 255 YRLF------------RTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILY 302 + F T + N Y + + R ++ Sbjct: 179 HEQFGDWSGALVDIQMDDPTDPALAERIADVLNPLTAYLKARCAERRADPGDDLISRLVL 238 Query: 303 CLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQA 362 + + E+ T +L G TT++ L + + + E+ Sbjct: 239 AEVDGRALDDEEAANFSTALLLAGHITTTVLLGNIVRTLDEHPAHWDAAAEDPGR----- 293 Query: 363 EGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMG 422 + A ++E LR P +QR + IPA +V + + Sbjct: 294 -------------IPAIVEEVLRYRPPFPQMQRTTTKATEVAGVPIPADVMVNTWVLSAN 340 Query: 423 RDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 RD PD+FDP+R L FG GV C+G +A LE + L I+ F Sbjct: 341 RDSDAHDDPDRFDPSRKSGGAAQ------LSFGHGVHFCLGAPLARLENRVALEEIIARF 394 >1CPT-A nrPDB Length = 428 Score = 166 bits (419), Expect = 3e-41, Method: Composition-based stats. Identities = 58/345 (16%), Positives = 110/345 (31%), Gaps = 47/345 (13%) Query: 139 VLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDI 198 + T R + P +I+ + ++Q V L + G F+ D Sbjct: 102 LTSMDPPTHTAYRGLTLNW-FQPASIRKLEENIRRIAQASVQRL---LDFDGECDFMTDC 157 Query: 199 KEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLF 258 + V E P K + + + P Sbjct: 158 ALYYPLHVVMTALGVP---------EDDEPLMLKLTQDFFGVHEPDEQAVAAPR------ 202 Query: 259 RTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKAN 318 ++ + + Y F D R + + L + + + A Sbjct: 203 --QSADEAARRFHETIATFYDYFNGFTVDRRSCPKDDVMSLLANSKLDGNYIDDKYINAY 260 Query: 319 ITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKA 378 + G +TTS + + ++R+ + L+ Sbjct: 261 YVAIATAGHDTTSSSSGGAIIGLSRNPEQLAL------------------AKSDPALIPR 302 Query: 379 SIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTR 438 + E +R + R +D ++ I + ++ + RD FS+PD+FD TR Sbjct: 303 LVDEAVRWTAPVKSFMRTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITR 362 Query: 439 WLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 + + R+LGFGWG C+G+ +A+LEM +F +L K Sbjct: 363 FPN--------RHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLK 399 >4DO1-A nrPDB Length = 410 Score = 166 bits (419), Expect = 3e-41, Method: Composition-based stats. Identities = 68/441 (15%), Positives = 148/441 (33%), Gaps = 65/441 (14%) Query: 73 RIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRY 132 + + + GP+ L + +V + ++ + Sbjct: 33 DDPYPDQQTLRDAGPV--VYLDKWNVYGVARYAEVHAVLNDPTTFCSSRGVGLSDFKKEK 90 Query: 133 YQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSG 192 +P ++ + + ++V++P +K + + + + + + + Q+G Sbjct: 91 PWRPPSLILEADPPAHTRPRAVLSKVLSPATMKT---IRDGFAAAADAKVDELL-QRGCI 146 Query: 193 KFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPP 252 + D+ E +F + +G+ +E + V+ F P Sbjct: 147 DAIADLAEAYPL--------SVFPDAMGLKQEG-REHLLPYAGLVFNAF-------GPPN 190 Query: 253 ELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPG-ILYCLLKSEKML 311 EL T ++ + + +R G ++ + ++ Sbjct: 191 ELR---------------QTAIERSAPHQAYVNEQCQRPNLAPGGFGACIHAFTDTGEIT 235 Query: 312 LEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQ 371 ++ + +L+ G++TT + +Y +AR + LR Sbjct: 236 PDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLR------------------S 277 Query: 372 MVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSP 431 L + + +E +R T R ++ L +I V + + + RDP +S P Sbjct: 278 DPTLARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDP 337 Query: 432 DKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGD 491 D +D TR S ++GFG GV CVG+ +A LE + L + + G Sbjct: 338 DLYDITRKTSG--------HVGFGSGVHMCVGQLVARLEGEVMLSALARKVAA-IDIDGP 388 Query: 492 VDTIFNLILTPDKPIFLVFRP 512 V FN L + + + P Sbjct: 389 VKRRFNNTLRGLESLPVKLTP 409 >4MM0-A nrPDB Length = 399 Score = 164 bits (414), Expect = 9e-41, Method: Composition-based stats. Identities = 65/392 (16%), Positives = 122/392 (31%), Gaps = 81/392 (20%) Query: 101 IIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMA 160 + EDV + + + R D+P + V+ + R +L + Sbjct: 50 VTRYEDVRFVL-SDPRFSVRQDLPGAPRLTEMTFES--VMTTDPPVHTRLRRLL-SRDFT 105 Query: 161 PEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLG 220 I+ P L +++ + + K+ DI E L Sbjct: 106 ARRIERMRPRLEEIAEGLLDEMEKK-------GAPADIVESL------------------ 140 Query: 221 MLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAA--------WDT 272 AV LL VP FR W D + + W Sbjct: 141 ---------------AVPFPITVICELLGVPMVDVARFR--GWADTMVSLTGYSMEDWTA 183 Query: 273 IFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSM 332 + E Y + R ++ + ++ DV++ +L G S Sbjct: 184 ARDALESYLDGLVAAKRENPGSDLLSALVATAAEDNELTDHDVRSLSLILLLAGYEPASN 243 Query: 333 TLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVT 392 L + + R + ++++ + LL ++++E +R P Sbjct: 244 QLGSSVLTLLRFPD------------------RLAELRRDPGLLPSAVEELMRYAPAGDG 285 Query: 393 -LQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRN 451 L R D+ + D IPA + V + A DP F P R + ++ Sbjct: 286 ALFRVTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTGLRLDRPDN--------QH 337 Query: 452 LGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 G G+ C+G +A +E+ + + +L F Sbjct: 338 TALGHGIHFCLGAALARVELQVAIGALLRRFP 369 >4OQS-A nrPDB Length = 433 Score = 164 bits (414), Expect = 1e-40, Method: Composition-based stats. Identities = 52/304 (17%), Positives = 98/304 (32%), Gaps = 38/304 (12%) Query: 183 HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFH 242 H R ++ +F ++L + + L + + P A+ Sbjct: 102 HTRYRRMLISQFTVRRIKELEPRIVQIT-----EDHLDAMAKAGPPVDLVQAFALPVPSL 156 Query: 243 TSVPLLNVPPELYRLFRTKT-WRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGIL 301 LL V + F+ +T V A + +L +L Sbjct: 157 VICELLGVSYADHAFFQEQTTIMASVDKTQDEVTTALGKLTRYIAELVATKRLSPKDDLL 216 Query: 302 YCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQ 361 L+ + E++ +L G TT+ L + + + L Sbjct: 217 GSLITDTDLTDEELTNIALLLLVAGHETTANMLGLGTFALLQHPEQIAALDS-------- 268 Query: 362 AEGDISKMLQMVPLLKASIKETLRLHPISV--TLQRYPESDLVLQDYLIPAKTLVQVAIY 419 +++E LR I T R D+ L+ +I V + + Sbjct: 269 ---------------PDAVEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLP 313 Query: 420 AMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHIL 479 A+ RDP F PD R ++ ++ FG G+ QC+G+++A +EM + + Sbjct: 314 AVNRDPKVFDEPDILQLDRVDAR-------KHAAFGGGIHQCLGQQLARVEMRIGFTRLF 366 Query: 480 ENFK 483 F Sbjct: 367 ARFP 370 >1ODO-A nrPDB Length = 408 Score = 163 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 74/454 (16%), Positives = 143/454 (31%), Gaps = 103/454 (22%) Query: 74 IHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKFE-------------GSYPER 120 H ++ GP + +++ + P + L G Sbjct: 16 DHHTEHRTLREGGPATWVDVLGVQAWSVSDPVLLKQLLTSSDVSKDARAHWPAFGEVVGT 75 Query: 121 YDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVS 180 + + W+A + +K R ++ + + P + + V Sbjct: 76 WPLALWVAVE-------NMFTAYGPNHRKLRRLVAP-AFSARRVDAMRPAVEAMVTGLVD 127 Query: 181 LLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKM 240 L + + GE + + +E P Sbjct: 128 RLAE----------------------------LPAGEPVDLRQELAYPL----------P 149 Query: 241 FHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDL------RRKTEF 294 L+ VP + FR D V +A+ T Y+ L +R T Sbjct: 150 IAVIGHLMGVPQDRRDGFRALV--DGVFDTTLDQAEAQANTARLYEVLDQLIAAKRATPG 207 Query: 295 RNYPGILYCLLKSE----KMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEM 350 + +L E ++ E+++ + M++ G TT + ++ + + + Sbjct: 208 DDMTSLLIAARDDEGDGDRLSPEELRDTLLLMISAGYETTVNVIDQAVHTLLTRPDQLAL 267 Query: 351 LRE-EVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQ-RYPESDLVL-QDYL 407 +R+ EV ++ETLR P L RY +D+ L Sbjct: 268 VRKGEVT-------------------WADVVEETLRHEPAVKHLPLRYAVTDIALPDGRT 308 Query: 408 IPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIA 467 I + + A R P + D FD TR + + +L FG GV C+G +A Sbjct: 309 IARGEPILASYAAANRHPDWHEDADTFDATRTVKE--------HLAFGHGVHFCLGAPLA 360 Query: 468 ELEMTLFLIHILENF-KVEMQ-HIGDVDTIFNLI 499 +E+TL L + F + + ++ + +LI Sbjct: 361 RMEVTLALESLFGRFPDLRLADPAEELPPVPSLI 394 >3A1L-A nrPDB Length = 425 Score = 161 bits (408), Expect = 5e-40, Method: Composition-based stats. Identities = 55/310 (17%), Positives = 106/310 (34%), Gaps = 44/310 (14%) Query: 183 HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFH 242 H ++ + +F I L E + ++ + + + F + + Sbjct: 106 HTELRSLLTTEFSPSIVTGLRPRIAELASALLD----RLRAQRRPDLVEGFAAPLPIL-- 159 Query: 243 TSVPLLNVPPELYRLFRT-----KTWRDHVAAWDTIFNKAEKYTEIFYQDLRR------- 290 LL +P E + R + A + +AE ++ F + RR Sbjct: 160 VISALLGIPEEDHTWLRANAVALQEASTTRARDGRGYARAEAASQEFTRYFRREVDRRGG 219 Query: 291 KTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEM 350 ++ + ++ + +L G TT+ L + + +V + Sbjct: 220 DDRDDLLTLLVRARDTGSPLSVDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDE 279 Query: 351 LREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPA 410 LR A+++E +R P + R+ D+ L D+ IP Sbjct: 280 LR------------------TTPESTPAAVEELMRYDPPVQAVTRWAYEDIRLGDHDIPR 321 Query: 411 KTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELE 470 + V + + RDPA F PD D R + +GFG G+ C+G +A E Sbjct: 322 GSRVVALLGSANRDPARFPDPDVLDVHRAAERQ--------VGFGLGIHYCLGATLARAE 373 Query: 471 MTLFLIHILE 480 + L +L+ Sbjct: 374 AEIGLRALLD 383 >4OQR-A nrPDB Length = 457 Score = 161 bits (408), Expect = 5e-40, Method: Composition-based stats. Identities = 51/306 (16%), Positives = 100/306 (32%), Gaps = 42/306 (13%) Query: 183 HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFH 242 H R ++ +F ++L + L + + P A+ Sbjct: 141 HTRYRRMLISQFTVRRIKELEPRIVRIT-----EDHLDAMAKAGPPVDLVQAFALPVPSL 195 Query: 243 TSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEI---FYQDLRRKTEFRNYPG 299 LL V + F+ +T + + D ++ + +L Sbjct: 196 VICELLGVSYADHAFFQEQT--TIMVSVDKTQDEVTTALGKLTRYIAELVATKRLSPKDD 253 Query: 300 ILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNAR 359 +L L+ + E++ +L G TT+ L + + + L Sbjct: 254 LLGSLITDTDLTDEELTNIALILLVAGHETTANMLGLGTFALLQHPEQIANLDS------ 307 Query: 360 RQAEGDISKMLQMVPLLKASIKETLRLHPISV--TLQRYPESDLVLQDYLIPAKTLVQVA 417 +++E LR I T R D+ L+ +I V + Sbjct: 308 -----------------PDAVEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIG 350 Query: 418 IYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIH 477 + A+ RDP F PD R ++ ++ FG G+ QC+G+++A +EM + Sbjct: 351 LPAVNRDPKVFDEPDILQLDRVDAR-------KHAAFGGGIHQCLGQQLARVEMRIGFTR 403 Query: 478 ILENFK 483 + F Sbjct: 404 LFARFP 409 >3TYW-A nrPDB Length = 417 Score = 161 bits (407), Expect = 6e-40, Method: Composition-based stats. Identities = 49/282 (17%), Positives = 88/282 (31%), Gaps = 32/282 (11%) Query: 206 AFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTW-- 263 A E L + P A LL +P FR T Sbjct: 125 AMRPAVQARVDEILDGMLAAGGPVDLVSAYANAVSTSVICELLGIPRHDLEFFRDVTRIS 184 Query: 264 ---RDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANIT 320 + R + ++ L + E + + + Sbjct: 185 GSRNSTAEQVSEALGGLFGLLGGLVAERREEPRDDLISKLVTDHLVPGNVTTEQLLSTLG 244 Query: 321 EMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASI 380 + G TT+ + + + LR++ L+ A++ Sbjct: 245 ITINAGRETTTSMIALSTLLLLDRPELPAELRKDPD------------------LMPAAV 286 Query: 381 KETLRLHPISVTLQ-RYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRW 439 E LR+ ++ ++ R D+ L +PA V + DP F P++ D R Sbjct: 287 DELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHRT 346 Query: 440 LSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILEN 481 + ++ FG+GV QCVG+ +A LE+ + L +L Sbjct: 347 DN--------HHVAFGYGVHQCVGQHLARLELEVALETLLRR 380 >4TX3-A nrPDB Length = 404 Score = 161 bits (407), Expect = 6e-40, Method: Composition-based stats. Identities = 49/312 (15%), Positives = 103/312 (33%), Gaps = 37/312 (11%) Query: 177 DFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDA 236 D+ H R++ + F L E +T +RL +E+ P + A Sbjct: 96 DYDPPEHTRLRHLLTPGFTQRRMRRLAPRIEEIVT-----DRLDAMEQAGPPADLIELFA 150 Query: 237 VYKMFHTSVPLLNVPPELYRLFRTKTWR--DHVAAWDTIFNKAEKYTEIFYQDLRRKTEF 294 L+ VP + +F R D + E + + R+ + Sbjct: 151 DEVPGAVLCELIGVPRDDQAMFLQLCHRHLDASLSARKRAAAGEAFARYLVAMMARERKD 210 Query: 295 RNYPGILYCLL--KSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLR 352 G + ++ + + E+++ +++ G + S + + + R LR Sbjct: 211 PG-DGFIGSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALR 269 Query: 353 EEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVT-LQRYPESDLVLQDYLIPAK 411 + +A ++ E +R + R D+++ D +I Sbjct: 270 GDDQSA------------------DRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEG 311 Query: 412 TLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEM 471 V ++ RD A D+ D TR ++ FG G+ C+G + L++ Sbjct: 312 ETVLCSLPMANRDRALLPDADRLDVTRTPVP--------HVAFGHGIHHCLGAALTRLQL 363 Query: 472 TLFLIHILENFK 483 + + F Sbjct: 364 RIAYTALWRRFP 375 >1LG9-A nrPDB Length = 398 Score = 161 bits (406), Expect = 8e-40, Method: Composition-based stats. Identities = 56/329 (17%), Positives = 106/329 (32%), Gaps = 37/329 (11%) Query: 177 DFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDA 236 D+ H R++++ + F + + + + + +RL +E +P A Sbjct: 90 DYDPPEHTRLRRKLTPGFTLRKMQRMAPYIEQIVN-----DRLDEMERAGSPADLIAFVA 144 Query: 237 VYKMFHTSVPLLNVPPELYRLFRTKTW--RDHVAAWDTIFNKAEKYTEIFYQDL--RRKT 292 L+ VP + +F D + +K++ + RK Sbjct: 145 DKVPGAVLCELVGVPRDDRDMFMKLCHGHLDASLSQKRRAALGDKFSRYLLAMIARERKE 204 Query: 293 EFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLR 352 G + + E+++ +++ G + S + + M R Sbjct: 205 PGEGMIGAVVAEYGDDA-TDEELRGFCVQVMLAGDDNISGMIGLGVLAMLRHP------- 256 Query: 353 EEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVT-LQRYPESDLVLQDYLIPAK 411 E++ R + ++ E +R + + R DL L I Sbjct: 257 EQIDAFRGDEQSAQ-----------RAVDELIRYLTVPYSPTPRIAREDLTLAGQEIKKG 305 Query: 412 TLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEM 471 V ++ A RDPA D+ D TR ++ FG GV C+G +A LE+ Sbjct: 306 DSVICSLPAANRDPALAPDVDRLDVTREP--------IPHVAFGHGVHHCLGAALARLEL 357 Query: 472 TLFLIHILENFKVEMQHIGDVDTIFNLIL 500 + F DT F L Sbjct: 358 RTVFTELWRRFPALRLADPAQDTEFRLTT 386 >4XE3-A nrPDB Length = 407 Score = 161 bits (406), Expect = 8e-40, Method: Composition-based stats. Identities = 50/309 (16%), Positives = 97/309 (31%), Gaps = 39/309 (12%) Query: 183 HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFH 242 H R+++ F E++ + +++ M+ + +F+ AV Sbjct: 101 HTRLRRLVGKAFTARRVEEMRPRVRSLVDSLLD----DMVAHGSPADLVEFL-AVPFPVA 155 Query: 243 TSVPLLNVPPELYRLFRT------KTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRN 296 LL VP E LFRT + R A + Y + R Sbjct: 156 VICELLGVPLEDRDLFRTFSDAMLSSTRLTAAEIQRVQQDFMVYMDGLVAQRRDAPTEDL 215 Query: 297 YPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVL 356 + + + ++ +L G T+ + ++ + Sbjct: 216 LGALALATDNDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLT------------- 262 Query: 357 NARRQAEGDISKMLQMVPLLKASIKETLRLHPISVT--LQRYPESDLVLQDYLIPAKTLV 414 ++ L+ A+++E LR P+ R D+ L + A Sbjct: 263 -----ERKRYESLVADPALVPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPC 317 Query: 415 QVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLF 474 V + RD F D+ D R + ++ FG G C+G ++ LE+ Sbjct: 318 VVHFASANRDEEVFDHADELDFHRERNP--------HIAFGHGAHHCIGAQLGRLELQEA 369 Query: 475 LIHILENFK 483 L ++ F Sbjct: 370 LSALVRRFP 378 >3NC3-A nrPDB Length = 441 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 63/341 (18%), Positives = 108/341 (31%), Gaps = 39/341 (11%) Query: 158 VMAPEAIKNFIPLLN-PVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFG 216 ++ P++ PV H ++ F+GD + L ++ N++ Sbjct: 95 FTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALDHLSPLIKQNAENLLAP 154 Query: 217 ERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRT--KTWRDHVAAWDTIF 274 + VN + F V ++ +L + + D + + Sbjct: 155 YLERGKSDLVNDFGKTFAVCV------TMDMLGLDKRDHEKISEWHSGVADFITSISQSP 208 Query: 275 NKAEKYTEIFYQ---------DLRRKTEFRNYPGILYCL-LKSEKMLLEDVKANITEMLA 324 Q RR + IL + + +D+ A I +L Sbjct: 209 EARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMALSDKDILALILNVLL 268 Query: 325 GGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETL 384 TL +Y + + +L L+ +I ETL Sbjct: 269 AATEPADKTLALMIYHLLNNPEQMN------------------DVLADRSLVPRAIAETL 310 Query: 385 RLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDK 444 R P + R D V+ I T+V I A RDP F PD F+ R K Sbjct: 311 RYKPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK 370 Query: 445 DLIHF--RNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 R+L FG G+ CVG A+ E+ + +L+ + Sbjct: 371 SAFSGAARHLAFGSGIHNCVGTAFAKNEIEIVANIVLDKMR 411 >4Z5Q-A nrPDB Length = 423 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 63/362 (17%), Positives = 126/362 (34%), Gaps = 51/362 (14%) Query: 159 MAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGER 218 M P A+ I ++P H R++ S F E + E ++ + Sbjct: 103 MTPRAVPESILTMDP-------PDHTRLRTLVSKAFTPRRIESKRAWIGELAAGLVADMK 155 Query: 219 LGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTI----- 273 G P A+ LL VP + R + W D + + Sbjct: 156 AG-----GAPAELVGSYALAIPVTVICELLGVPEDDR--TRLRGWCDAALSTGELTDEEC 208 Query: 274 ---FNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTT 330 F +KY E ++ R + ++ +++ ++ +L GG TT Sbjct: 209 VQSFMDLQKYFEDLVKERRAEPRDDLTSALIEARDAHDRLAEPELIGLCISILIGGFETT 268 Query: 331 SMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPIS 390 + + ++ + + + L + A+++E LR P + Sbjct: 269 ASEISSFVHVLQQRRELWTRL------------------CADPEAIPAAVEELLRFVPFA 310 Query: 391 V--TLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIH 448 RY D+ + L+ V V A+ RD F + D+ R + Sbjct: 311 ANGISPRYALEDMTVGGVLVREGEPVIVDTSAVNRDGLVFDNADEVVIDRADN------- 363 Query: 449 FRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFL 508 R++ FG G C+G +A +E+ L ++E ++ GDV+ ++I+ + + + Sbjct: 364 -RHMVFGHGAHHCLGAHLARVELQEALKALVEGMP-GLRLSGDVEWKADMIIRAPRVMHV 421 Query: 509 VF 510 + Sbjct: 422 EW 423 >6FSH-A nrPDB Length = 398 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 48/312 (15%), Positives = 104/312 (33%), Gaps = 37/312 (11%) Query: 177 DFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDA 236 D+ H R++ + F L E +T +RL +E+ P + A Sbjct: 90 DYDPPEHTRLRHLLTPGFTQRRMRRLAPRIEEIVT-----DRLDAMEQAGPPADLIELFA 144 Query: 237 VYKMFHTSVPLLNVPPELYRLFRTKTW--RDHVAAWDTIFNKAEKYTEIFYQDLRRKTEF 294 L+ VP + +F D + +K++ + R+ + Sbjct: 145 DEVPGAVLCELIGVPRDDRDMFMKLCHGHLDASLSQKRRAALGDKFSRYLLAMIARERKD 204 Query: 295 RNYPGILYCLL--KSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLR 352 G + ++ + + E+++ +++ G + S + + + R LR Sbjct: 205 PG-DGFIGSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALR 263 Query: 353 EEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVT-LQRYPESDLVLQDYLIPAK 411 + +A ++ E +R + R D+++ D +I Sbjct: 264 GDDQSA------------------DRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEG 305 Query: 412 TLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEM 471 V ++ RD A D+ D TR ++ FG G+ C+G + L++ Sbjct: 306 ETVLCSLPMANRDRALLPDADRLDVTRTPVP--------HVAFGHGIHHCLGAALTRLQL 357 Query: 472 TLFLIHILENFK 483 + + F Sbjct: 358 RIAYTALWRRFP 369 >5Z9I-A nrPDB Length = 398 Score = 158 bits (399), Expect = 5e-39, Method: Composition-based stats. Identities = 61/379 (16%), Positives = 125/379 (32%), Gaps = 54/379 (14%) Query: 141 FKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKE 200 + +S + V +++ M + IK ++ H+R++ F + Sbjct: 41 YPESAAILSNPKVFSSDTMRLDPIKLDEAIVEGDFAHTDPPKHRRLRGLVDHAFTPSLVA 100 Query: 201 DLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRT 260 + I ++ G ++ +F + + + LL VP LFR Sbjct: 101 KMESRVHGIIHELLDGVE----GKSQFDLVAEFAAPLPLIMISD--LLGVPESDRALFRQ 154 Query: 261 KTWRDHVAAWDTIFNK--------------------AEKYTEIFYQDLRRKTEFRNYPGI 300 W D + F Y + R++ + Sbjct: 155 --WMDKMLDGSEKFESPETVLEQEEELHKELELLWEMRDYWHERAAESRKRPREDLISQL 212 Query: 301 LYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARR 360 ++ + +K+ + +L G TT+M + + + + +R Sbjct: 213 VHAEVDGQKLNDSQISNIANRLLVNGHLTTAMLIANTMLCLDAFSDQDARVR-------- 264 Query: 361 QAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYA 420 L+ A ++E++R + R S++ + +IP L+ V A Sbjct: 265 ----------ADRSLVPALLEESMRYMSPICGVGRATNSEVEVAGTVIPKDQLLLVWTGA 314 Query: 421 MGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILE 480 RD F PD FD R + +LGFG G+ C+GR++A +E + +L+ Sbjct: 315 ANRDERQFEKPDVFDAGRSPNA--------HLGFGRGIHFCLGRQLARMESKAAVEILLD 366 Query: 481 NFKVEMQHIGDVDTIFNLI 499 + T ++ Sbjct: 367 RLPTLRADPANPPTFLQVV 385 >3TKT-A nrPDB Length = 450 Score = 158 bits (399), Expect = 5e-39, Method: Composition-based stats. Identities = 74/380 (19%), Positives = 129/380 (33%), Gaps = 52/380 (13%) Query: 153 VLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITN 212 L M +AI P L + H ++++ F+ L + Sbjct: 102 TLRVGEMMAKAITGGSPHLVESLVQMDAPKHPKLRRLTQDWFMPKNLARLDGEIRKIANE 161 Query: 213 VMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYR--LFRTKTW---RDHV 267 + +R+ E + A + A H + +L VPPE LF T+ +D Sbjct: 162 AI--DRMLGAGEEGDFMA---LVAAPYPLHVVMQILGVPPEDEPKMLFLTQQMFGGQDED 216 Query: 268 AAWDTIFN---------------KAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLL 312 + + + E+Y + RR I ++ E M Sbjct: 217 MNKSGLKDLPPEQISQIVAGAVAEFERYFAGLAAERRRNPTDDVATVIANAVVDGEPMSD 276 Query: 313 EDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQM 372 D + G +TTS + +AR ++ ++ Sbjct: 277 RDTAGYYIITASAGHDTTSASSAGAALALARDPDLFARVK------------------AD 318 Query: 373 VPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPD 432 LL ++E +R R +D L I A + + A DPA F P Sbjct: 319 RNLLPGIVEEAIRWTTPVQHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPR 378 Query: 433 KFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDV 492 KFDPTR + R+L FG G QC+G +A LEM + L +L+ ++ G+ Sbjct: 379 KFDPTRPAN--------RHLAFGAGSHQCLGLHLARLEMRVLLDVLLDRVD-SLELAGEP 429 Query: 493 DTIFNLILTPDKPIFLVFRP 512 + + + K + + ++ Sbjct: 430 KRVNSTFVGGFKSLPMRWKA 449 >4PWV-A nrPDB Length = 446 Score = 158 bits (399), Expect = 6e-39, Method: Composition-based stats. Identities = 61/374 (16%), Positives = 130/374 (34%), Gaps = 61/374 (16%) Query: 139 VLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDI 198 + + R VL +P+A+K P+++ + + + L ++G F D+ Sbjct: 118 LAVTDGAMHRGLRNVLLK-SFSPQALK---PIVDQI-RVNTTRLVVDAARRGECDFAADV 172 Query: 199 KEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLF 258 E + + V +R +L+ + + + D L R Sbjct: 173 AEQIPLNTISDLLGVPAADREFLLKLNKSALSSEDADQSATD-----------AWLAR-- 219 Query: 259 RTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKAN 318 N+ Y + R K + ++ + + E + N Sbjct: 220 ----------------NEILLYFSELVAERRAKPTEDVISVLANSMVDGKPLTEEVIVLN 263 Query: 319 ITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKA 378 ++ GG T+ +++ + + + E+LR+ + L++ Sbjct: 264 CYSLILGGDETSRLSMIDSVQTFTQYPDQWELLRDGKVT------------------LES 305 Query: 379 SIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTR 438 + +E LR ++ R +D+ L +I A +V + + RD F+ P FD R Sbjct: 306 ATEEVLRWATPAMHFGRRAVTDMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDLNR 365 Query: 439 WLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNL 498 +K ++ FG+G C+G + E+ L L + + G+ I + Sbjct: 366 SPNK--------HITFGYGPHFCLGAYLGRAEVHALLDA-LRTYTTGFEITGEPQRIHSN 416 Query: 499 ILTPDKPIFLVFRP 512 LT + + +P Sbjct: 417 FLTGLSRLPVRIQP 430 >1EHE-A nrPDB Length = 403 Score = 158 bits (399), Expect = 6e-39, Method: Composition-based stats. Identities = 63/434 (14%), Positives = 138/434 (31%), Gaps = 74/434 (17%) Query: 87 PIYREKLG-NLESVYIIHPEDVAHLFKFE--GSYPERYDIPPWLAYHRYYQKPIGVLFKK 143 P+ + KL + + +DV + E R P A + K Sbjct: 30 PVSQVKLFDGSLAWLVTKHKDVCFVATSEKLSKVRTRQGFPELSASGKQAAKAKPTFVDM 89 Query: 144 SGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLF 203 + + PEA+KN P + D + + ++ G V + + Sbjct: 90 DPPEHMHQRSMVEPTFTPEAVKNLQPYIQRTVDDLLEQMKQKGCANGPVDLVKEFALPVP 149 Query: 204 HFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTW 263 + ++ V F + + ++ R + T Sbjct: 150 SYIIYTLLGVPFNDLEYLTQQNA----------------------------IRTNGSSTA 181 Query: 264 RDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEML 323 R+ AA + Y I + + + + +K + D +L Sbjct: 182 REASAANQELL----DYLAILVEQRLVEPKDDIISKLCTEQVKPGNIDKSDAVQIAFLLL 237 Query: 324 AGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKET 383 G T + + +A+ + ++++ L ++E Sbjct: 238 VAGNATMVNMIALGVATLAQHPD------------------QLAQLKANPSLAPQFVEEL 279 Query: 384 LRLHPI-SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSK 442 R H ++ ++R + D+++ D L+ A + + + RD F +PD+F+ R Sbjct: 280 CRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNRKWPP 339 Query: 443 DKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTP 502 LGFG+G +C+ +A+ E+T + + F +++ + Sbjct: 340 QDP------LGFGFGDHRCIAEHLAKAELTTVFSTLYQKFP-DLKVAVPLGK-------- 384 Query: 503 DKPIFLVFRPFNQD 516 + + P N+D Sbjct: 385 -----INYTPLNRD 393 >5H1Z-A nrPDB Length = 407 Score = 158 bits (399), Expect = 6e-39, Method: Composition-based stats. Identities = 50/325 (15%), Positives = 114/325 (35%), Gaps = 46/325 (14%) Query: 183 HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFH 242 H ++ + F + V+ + V+ + + + + Sbjct: 99 HTGQRRTVAPAFTPSEMVRMSDNIRMRTAEVLDSLEWNTPFDWVDTVSVELTTQMLAI-- 156 Query: 243 TSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTE---------IFYQDLRRKTE 293 L + P E R W D + + N+ + F K Sbjct: 157 ----LFDFPWEERRKLTF--WSDWAGDIELVKNEELRLERLRHMYECGGYFQNLWNAKIG 210 Query: 294 FRNYPGILYCLLKSE---KMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEM 350 P ++ ++ S+ +M + N+ ++ GG +TT T+ Y + + + Sbjct: 211 KPPTPDLISMMIHSDAMAEMDQMEFLGNLILLIVGGNDTTRNTMSAVAYGLDLFPDQRAK 270 Query: 351 LREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPA 410 L ++ +++E +R ++R D L+ I A Sbjct: 271 LE------------------ADPSMIPNTVQEIIRWQTPLAHMRRTATVDSELEGQQIKA 312 Query: 411 KTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELE 470 + + + RD + F + D+ R ++ R+L FG G+ +CVG R+AEL+ Sbjct: 313 GDKLALWYISANRDESVFENADRIIVDRPNAR-------RHLAFGHGIHRCVGARLAELQ 365 Query: 471 MTLFLIHILENFKVEMQHIGDVDTI 495 + + L + + ++ + +G+ + + Sbjct: 366 IAVLLEEMAKR-RMRVNVLGEPERV 389 >6HQD-A nrPDB Length = 420 Score = 158 bits (398), Expect = 7e-39, Method: Composition-based stats. Identities = 48/319 (15%), Positives = 107/319 (33%), Gaps = 50/319 (15%) Query: 195 VGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPEL 254 + + + ++ + GE ++ + + M + LL+ P + Sbjct: 129 LLRFEATIRERTKRVLSELPIGEEFNWVD--------RVSIELTTMMLAT--LLDFPFDD 178 Query: 255 YRLFRTKTWRD---------HVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLL 305 R W D V +W+ ++ + F + + P ++ L Sbjct: 179 RRKLTR--WSDIITTRPGYGLVDSWEQRESELMECLAYFQRLYAERQAMPPKPDLISMLA 236 Query: 306 KSEKM---LLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQA 362 S +M D + ++ GG +TT ++ Sbjct: 237 HSPEMQDLTPTDFLGTLALLIVGGNDTTRSSMSGSAMACHLYPQ---------------- 280 Query: 363 EGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMG 422 + K+ LL + I E +R ++R D+ + I V + + Sbjct: 281 --EFDKVRNNRALLASVIPEVVRWQTPIAHMRRTALEDVEFRGKQIRKGDKVVMWYLSGN 338 Query: 423 RDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 RD P F R ++ +L FG+G+ +C+G R+AEL++ + + E + Sbjct: 339 RDDEVIDRPMDFIADRPRAR-------HHLSFGFGIHRCLGNRLAELQLKILWEEMCERY 391 Query: 483 KVEMQHIGDVDTIFNLILT 501 ++ G+ + + ++ Sbjct: 392 S-RIEVCGEPVRVPSNLVH 409 >1GWI-A nrPDB Length = 411 Score = 158 bits (398), Expect = 7e-39, Method: Composition-based stats. Identities = 66/409 (16%), Positives = 130/409 (31%), Gaps = 72/409 (17%) Query: 86 GPIYREKL-GNLESVYIIHPEDVAHLFKFEGSYPE--------RYDIPPWLAYHRYYQKP 136 GP+ +L G + + H + L + R +IP Sbjct: 30 GPLAAVELPGGVPVWAVTHHAEAKALLTDPRLVKDINVWGAWRRGEIPADWPLIGLANPG 89 Query: 137 IGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVG 196 +L ++ R + V+Q + ++ + + + Sbjct: 90 RSMLTVDGAEHRRLRTL--------------------VAQALTVRRVEHMRGRIT-ELTD 128 Query: 197 DIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYR 256 + ++L G + + P + + + +P L V E + Sbjct: 129 RLLDELPA----------DGGVVDLKAAFAYPLPMYVVADLMGIEEARLPRLKVLFE--K 176 Query: 257 LFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVK 316 F T+T + V A T T R ++ + + ++ Sbjct: 177 FFSTQTPPEEVVATLTELASIMTDT---VAAKRAAPGDDLTSALIQASENGDHLTDAEIV 233 Query: 317 ANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLL 376 + + M+A G TT + + ++ + ++ L Sbjct: 234 STLQLMVAAGHETTISLIVNAVVNLSTHPEQRALV------------------LSGEAEW 275 Query: 377 KASIKETLRLHPI-SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFF-SSPDKF 434 A ++ETLR S L R+ D+ + D +IPA + V+ A+GRD + D+F Sbjct: 276 SAVVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADRF 335 Query: 435 DPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 D TR R++ FG G C G ++ +E + L + F Sbjct: 336 DLTRTSGN-------RHISFGHGPHVCPGAALSRMEAGVALPALYARFP 377 >3SN5-A nrPDB Length = 491 Score = 157 bits (397), Expect = 1e-38, Method: Composition-based stats. Identities = 90/490 (18%), Positives = 159/490 (32%), Gaps = 99/490 (20%) Query: 77 RHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKP 136 N +K+G ++ KL +I +P + G Y + Sbjct: 38 FLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVL-CHGKYFD----------------- 79 Query: 137 IGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIP-----------------LLNPVSQDFV 179 WKK L+ + +I LN +++ + Sbjct: 80 ----------WKKFHFALSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMM 129 Query: 180 SLLHKRIKQQGSGK------FVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKF 233 L + ++ S + + FE+ +FG L +T Sbjct: 130 ENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDL-TRRDTQKAHILNN 188 Query: 234 IDAVYKMFHTSVPLL--NVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRK 291 +D +K F P L +P ++R + + K E +E+ + Sbjct: 189 LDN-FKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLN 247 Query: 292 TEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEML 351 + + E K ++ + A NT T W L++M R+ + Sbjct: 248 DTLSTFDDL------------EKAKTHLVVLWASQANTIPATF-WSLFQMIRNPEAMKAA 294 Query: 352 REEVLNARRQAEGDIS----------KMLQMVPLLKASIKETLRLHPISVTLQRYPESDL 401 EEV A +S L +P+L + IKE+LRL S+ + R + D Sbjct: 295 TEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI-RTAKEDF 353 Query: 402 VL----QDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKD----------LI 447 L Y I ++ + M DP + P F R+L ++ + Sbjct: 354 TLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKL 413 Query: 448 HFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEM-----QHIGDVDTIFNL-ILT 501 + + FG G C GR A E+ FLI +L F++E+ + + L IL Sbjct: 414 KYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILP 473 Query: 502 PDKPIFLVFR 511 P I ++ Sbjct: 474 PLNDIEFKYK 483 >2WM5-A nrPDB Length = 435 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 46/345 (13%), Positives = 112/345 (32%), Gaps = 42/345 (12%) Query: 178 FVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFID-A 236 H+R++ S F + + + ++ M+ + +A + A Sbjct: 120 LDDPRHQRLRSIVSRAFTPKVVARIEAAVRDRAHRLVSS----MIANNPDRQADLVSELA 175 Query: 237 VYKMFHTSVPLLNVP-PELYRLFRTKTW------RDHVAAWDTIFNKAEK---YTEIFYQ 286 ++ +P + R+F D +D + Y + Sbjct: 176 GPLPLQIICDMMGIPKADHQRIFHWTNVILGFGDPDLATDFDEFMQVSADIGAYATALAE 235 Query: 287 DLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLN 346 D R ++ + E++ ++ + ++ G TT + + ++R Sbjct: 236 DRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALSRYPE 295 Query: 347 VQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDY 406 ++ + L +++E +R V ++R D+ L+ Sbjct: 296 QRDRWWSDFDG-----------------LAPTAVEEIVRWASPVVYMRRTLTQDIELRGT 338 Query: 407 LIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGF-GWGVRQCVGRR 465 + A V + + RD + F+ P FD R + +LGF G G C+G Sbjct: 339 KMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNP--------HLGFGGGGAHFCLGAN 390 Query: 466 IAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVF 510 +A E+ + + ++ + + + + K + + + Sbjct: 391 LARREIRVAFDELRRQMP-DVVATEEPARLLSQFIHGIKTLPVTW 434 >5LIV-A nrPDB Length = 450 Score = 156 bits (395), Expect = 2e-38, Method: Composition-based stats. Identities = 70/346 (20%), Positives = 118/346 (34%), Gaps = 55/346 (15%) Query: 138 GVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGD 197 G+ + + R V N P A+ + + FV + +++ + +GK D Sbjct: 122 GLAAMQGDEHARMRRVYNMF-FLPRAVSQYE-------ERFVRPISEQVVDRLAGKPRVD 173 Query: 198 IKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRL 257 + ED + +FG L ET + V M V + Sbjct: 174 LLEDFAMELPRRVIGELFGFPAEKLHETD--------ERVRAMLRGLVRM---------- 215 Query: 258 FRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKA 317 VA + + + R T IL L +E + Sbjct: 216 ----HDPAAVAESQRAYGETLGLITEVVERESRDTSDTLLGEILRTLKAEHMDTIEASRQ 271 Query: 318 NITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLK 377 + ++ GG TTS + ++ + + +R Q LL Sbjct: 272 IVLSLILGGYETTSWLVANTIHALLAHPDTLARVR------------------QDPSLLP 313 Query: 378 ASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPT 437 A+I+E +R P S + R E D+ L D + A T+V +A A D + SP+ +D Sbjct: 314 AAIEEGMRWCPSSFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDID 373 Query: 438 RWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 R ++ FG G CVG +A +E + L +L F Sbjct: 374 RKPLPAANV-------FGGGAHFCVGAPLARMEARVGLQALLARFP 412 >6F88-A nrPDB Length = 400 Score = 156 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 69/346 (19%), Positives = 118/346 (34%), Gaps = 55/346 (15%) Query: 138 GVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGD 197 G+ + + R V N P A+ + + FV + +++ + +GK D Sbjct: 72 GLAAMQGDEHARMRRVYNMF-FLPRAVSQYE-------ERFVRPISEQVVDRLAGKPRVD 123 Query: 198 IKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRL 257 + ED + +FG L ET + V M V + Sbjct: 124 LLEDFAMELPRRVIGELFGFPAEKLHETD--------ERVRAMLRGLVRM---------- 165 Query: 258 FRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKA 317 VA + + + R T IL L +E + Sbjct: 166 ----HDPAAVAESQRAYGETLGLITEVVERESRDTSDTLLGEILRTLKAEHMDTIEASRQ 221 Query: 318 NITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLK 377 + ++ GG TTS + ++ + + +R Q LL Sbjct: 222 IVLSLILGGYETTSWLVANTIHALLAHPDTLARVR------------------QDPSLLP 263 Query: 378 ASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPT 437 A+I+E +R P + + R E D+ L D + A T+V +A A D + SP+ +D Sbjct: 264 AAIEEGMRWCPSNFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDID 323 Query: 438 RWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 R ++ FG G CVG +A +E + L +L F Sbjct: 324 RKPLPAANV-------FGGGAHFCVGAPLARMEARVGLQALLARFP 362 >5YSW-A nrPDB Length = 441 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 67/375 (17%), Positives = 125/375 (33%), Gaps = 57/375 (15%) Query: 151 RVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLL-----------------HKRIKQQGSGK 193 R VL+ + + + + P +S +F L H R ++ +G+ Sbjct: 87 RAVLSDPRFSSDRFQ-YHPWFKELSPEFRERLRDDKARAGSFINMDPPEHTRYRKLLTGQ 145 Query: 194 FVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPE 253 F +L E + R+ + A LL V E Sbjct: 146 FTVRRIRELGARIDEIVAG-----RVDAMLAGGTTADLMTEFAFPAPSLMICELLGVRYE 200 Query: 254 LYRLFRTK-----TWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSE 308 F+ + VA + + + D R G+++ Sbjct: 201 DRAEFQQRASALLQMNAPVAEAVKNADALRAFMQALVTDKRANPAGDIISGLIHHAGADP 260 Query: 309 KMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISK 368 + +++ +L G +TT+ L ++ + + LR++ Sbjct: 261 ALTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDDPSRIAD-------- 312 Query: 369 MLQMVPLLKASIKETLRLHPIS-VTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAF 427 +++E LR + + R+ + DL IPA + V V++ A RD Sbjct: 313 ----------AVEELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARH 362 Query: 428 FSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF-KVEM 486 + PD D TR +L FG GV QC+G+++A +EM +L V + Sbjct: 363 WPDPD-LDLTRPRGP--------HLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRL 413 Query: 487 QHIGDVDTIFNLILT 501 + + N +LT Sbjct: 414 AVPPEEVPLRNDMLT 428 >2XKR-A nrPDB Length = 398 Score = 155 bits (392), Expect = 4e-38, Method: Composition-based stats. Identities = 67/423 (15%), Positives = 135/423 (31%), Gaps = 73/423 (17%) Query: 87 PIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGT 146 P++R++ G + V + + I P P+ + Sbjct: 32 PVFRDRNGLA---AASTYQAVIDAERQPELFSNAGGIRP-----DQPALPMMIDMDDPA- 82 Query: 147 WKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFA 206 R L + +K+ + + + + +R G FV D+ L Sbjct: 83 -HLLRRKLVNAGFTRKRVKDKEASIAALCDTLIDAVCER----GECDFVRDLAAPLPMAV 137 Query: 207 FESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDH 266 G+ LG+ E ++ D + + V ++ Sbjct: 138 I--------GDMLGVRPE-QRDMFLRWSDDLVTFLSSHVS-----------------QED 171 Query: 267 VAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGG 326 F +T R ++ + E++ +++ +L GG Sbjct: 172 FQITMDAFAAYNDFTRATIAARRADPTDDLVSVLVSSEVDGERLSDDELVMETLLILIGG 231 Query: 327 VNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRL 386 TT TL ++ R+ + ++L+ + LL +I+E LR Sbjct: 232 DETTRHTLSGGTEQLLRNRDQWDLLQ------------------RDPSLLPGAIEEMLRW 273 Query: 387 HPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDL 446 + R +D + A + + + D A F P+KFD R + Sbjct: 274 TAPVKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQRNPN----- 328 Query: 447 IHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPI 506 +L FG+G C+G ++A LE++L +L + D+ + + + P +P Sbjct: 329 ---SHLAFGFGTHFCLGNQLARLELSLMTERVLRR-------LPDLRLVADDSVLPLRPA 378 Query: 507 FLV 509 V Sbjct: 379 NFV 381 >5DE9-A nrPDB Length = 410 Score = 155 bits (392), Expect = 4e-38, Method: Composition-based stats. Identities = 57/306 (18%), Positives = 101/306 (33%), Gaps = 42/306 (13%) Query: 220 GMLEETVNPEAQK-----FIDAVYKMFH--TSVPLLNVPPELYR----LFRTKTWRDHVA 268 GML+E V+ + +AV F L+ VP + H A Sbjct: 126 GMLDELVDAMLRAGPPADLTEAVLSPFPIAVICELMGVPATDRHSMHTWTQLILSSSHGA 185 Query: 269 AWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVN 328 LR + + +L + +++ L + + GG Sbjct: 186 EVSERAKNEMNAYFSDLIGLRSDSAGEDVTSLLGAAVGRDEITLSEAVGLAVLLQIGG-E 244 Query: 329 TTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHP 388 + + + + E LR E + +I E LR P Sbjct: 245 AVTNNSGQMFHLLLSRPELAERLRSE------------------PEIRPRAIDELLRWIP 286 Query: 389 --ISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDL 446 +V L R D+ ++ I A V V+ A RDP F PD+ D R + Sbjct: 287 HRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFERSPNP---- 342 Query: 447 IHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK-VEMQHIG-DVDTIFNLILTPDK 504 ++ FG+G C G +A LE L + +L+ +++ DV ++ + Sbjct: 343 ----HVSFGFGPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDVPFKKGALIRGPE 398 Query: 505 PIFLVF 510 + + + Sbjct: 399 ALPVTW 404 >5NWS-A nrPDB Length = 435 Score = 155 bits (391), Expect = 4e-38, Method: Composition-based stats. Identities = 65/440 (14%), Positives = 137/440 (31%), Gaps = 80/440 (18%) Query: 74 IHFRHIENFQKYGPIYREK-LGNLESVYIIHPEDVAHLFK------FEGSYPERYDIPPW 126 F ++ GP+ R + + ++ +DV + + P P Sbjct: 35 DPFTGYGRLRERGPVVRGRFVDGTPVWFVTRYDDVRAVLRDPRFVNTPSPVPGEGGADPR 94 Query: 127 LAYHRYYQKP-------IGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFV 179 P +G + L T A I P + ++ + Sbjct: 95 EGMMDLLNVPEPLRVYLLGSILDSDPPDHPRLRRLVTRAFAARRILGLRPGIERIADRLL 154 Query: 180 SLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYK 239 + L +R ++ G+ + +LE P + I Sbjct: 155 AELPRREEEDGT---------------------------VDLLEHFAYPLSITVI----- 182 Query: 240 MFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPG 299 L+ +P +R + + + + ++ + ++ Sbjct: 183 -----CELVGIPATDLERWREWGGDLVSMRPERLRHSFPVMIDYCHRLIEQRRAA-LTDD 236 Query: 300 ILYCLLKS-----EKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREE 354 +L L+++ ++ + I ++ G T++ + + +LR++ Sbjct: 237 LLSELIRAQDDDGGRLSDIETVTMILTLVLAGHETSAHLIGNGTAALLTHPGQWALLRKD 296 Query: 355 VLNARRQAEGDISKMLQMVPLLKASIKETLRL-HPISVTLQRYPESDLVLQDYLIPAKTL 413 LL ++ E +R + V RY DL L + Sbjct: 297 ------------------PALLPRAVHELMRWCGSVHVARLRYATEDLELAGTPVARGDA 338 Query: 414 VQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTL 473 VQ+ + + DP +S PD+ D TR + ++GFG G+ C+G +A E + Sbjct: 339 VQLVLVSANFDPRHYSDPDRLDITRHQEGQAE----NHVGFGHGIHYCLGATLARQEGEV 394 Query: 474 FLIHILENFKVEMQHIGDVD 493 L +LE + GD + Sbjct: 395 ALARLLETYPDLALADGDPE 414 >5IT1-A nrPDB Length = 399 Score = 154 bits (390), Expect = 7e-38, Method: Composition-based stats. Identities = 52/347 (14%), Positives = 111/347 (31%), Gaps = 65/347 (18%) Query: 139 VLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDI 198 +L++ + DR +L E ++ P + + + + + R D+ Sbjct: 87 LLWQDAPEHTDDRKLLAKE-FTVRRMQALRPNIQRIVDEHLDAIEAR-------GGPVDL 138 Query: 199 KEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLF 258 + + + + +FG E Q+ +A+ ++ Sbjct: 139 VKTFANPVPSMVISDLFGVPAER-----RAEFQEIAEAMMRV------------------ 175 Query: 259 RTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKAN 318 D AA RR + L + ++ + N Sbjct: 176 ------DQDAAATEAAGMRLGGLLYQLVQERRANPGDDLISALITTEDPDGVIDDMFLMN 229 Query: 319 IT-EMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLK 377 +L +TT+ + + + +L+++ L+ Sbjct: 230 AAGTLLIAAHDTTACMIGLGTALLLDRPDQLALLQKD------------------PSLIG 271 Query: 378 ASIKETLRLHPISV-TLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDP 436 +++E LR I +R D + I V + + DPAF P++FD Sbjct: 272 NAVEELLRYLTIGQFGAERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDI 331 Query: 437 TRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 TR + +L FG+G QC+G+++A +E+ + + F Sbjct: 332 TRRPAP--------HLAFGFGAHQCIGQQLARIELQIVFGTLFRRFP 370 >5DQN-A nrPDB Length = 426 Score = 154 bits (388), Expect = 1e-37, Method: Composition-based stats. Identities = 47/273 (17%), Positives = 95/273 (34%), Gaps = 44/273 (16%) Query: 240 MFHTSVPLLNVPPELY-RLFRTKTWRDHV-AAWDTIFNKAEKYTEIF-----YQDLRRKT 292 LL VP + +LFR W + + A D + + F + + Sbjct: 158 PLQAIAELLGVPQDDRDKLFR---WSNEMTAGEDPEYADVDPAMSSFELISYAMKMAEER 214 Query: 293 EFRNYPGILYCLLKS----EKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQ 348 I+ L+++ EK+ ++ + + G TT ++ + A++ + Sbjct: 215 AVNPTEDIVTKLIEADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFAQNPDQW 274 Query: 349 EMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLI 408 E+ ++E + + E +R QR D+ L I Sbjct: 275 ELYKKERP--------------------ETAADEIVRWATPVSAFQRTALEDVELGGVQI 314 Query: 409 PAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGW-GVRQCVGRRIA 467 V ++ + D F P F+ R + ++GFG G C+G +A Sbjct: 315 KKGQRVVMSYRSANFDEEVFEDPHTFNILRSPNP--------HVGFGGTGAHYCIGANLA 366 Query: 468 ELEMTLFLIHILENFKVEMQHIGDVDTIFNLIL 500 + + L I +N +++ IG + + + L Sbjct: 367 RMTINLIFNAIADNMP-DLKPIGAPERLKSGWL 398 >6DCD-A nrPDB Length = 424 Score = 153 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 60/274 (21%), Positives = 95/274 (34%), Gaps = 39/274 (14%) Query: 222 LEETVNPEAQKFIDAVYKMFHTSV--PLLNVPPELYRLFRTKTWRDHVAAWDTI------ 273 L+E + +FI K F T V LL VP + + FR D + + Sbjct: 137 LDEFLGAGECEFISEYAKPFATLVIADLLGVPEDDRKDFRVVLGADRMGRVGALDHESVG 196 Query: 274 ---FNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLE--DVKANITEMLAGGVN 328 + + +D RR+ + E DV + T + A G Sbjct: 197 VNPLQWLDDKFSAYIEDRRRQPRNDVLTALATATYPDGS-TPEVIDVVRSATFLFAAGQE 255 Query: 329 TTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHP 388 TT+ L + + ++Q LRE L+ I+E+LR+ Sbjct: 256 TTAKLLTAAMRVLGDRPDIQRRLRE------------------NRSLIPNFIEESLRMDS 297 Query: 389 ISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIH 448 + R + I A T+V V A RDP F P +F R ++ Sbjct: 298 PVKSDSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDRPNVRE----- 352 Query: 449 FRNLGFGWGVRQCVGRRIAELEMTLFLIHILENF 482 ++ F GV C G +A +E + L IL+ Sbjct: 353 --HMAFARGVHSCPGGPLARVEGRVSLERILDRM 384 >3ABA-A nrPDB Length = 403 Score = 152 bits (384), Expect = 3e-37, Method: Composition-based stats. Identities = 60/389 (15%), Positives = 120/389 (30%), Gaps = 72/389 (18%) Query: 101 IIHPEDVAHLFKFEGSYPERYDIPPWLAYHR----YYQKPIGVLFKKSGTWKKDRVVLNT 156 + E+V L + +P L +L++ DR +L Sbjct: 48 VTGYEEVRALLR---DSSFSVQVPHALHTQDGVVTQKPGRGSLLWQDEPEHTSDRKLLAK 104 Query: 157 EVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFG 216 E ++ P + + + + + R D+ + + + + +FG Sbjct: 105 E-FTVRRMQALRPNIQRIVDEHLDAIEAR-------GGPVDLVKTFANAVPSMVISDLFG 156 Query: 217 ERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNK 276 + E + +A+ ++ D AA Sbjct: 157 VPVERRAEFQD-----IAEAMMRV------------------------DQDAAATEAAGM 187 Query: 277 AEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANIT-EMLAGGVNTTSMTLQ 335 RR + L + ++ + N +L +TT+ + Sbjct: 188 RLGGLLYQLVQERRANPGDDLISALITTEDPDGVVDDMFLMNAAGTLLIAAHDTTACMIG 247 Query: 336 WHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISV-TLQ 394 + S + +LRE+ L+ +++E LR I + Sbjct: 248 LGTALLLDSPDQLALLRED------------------PSLVGNAVEELLRYLTIGQFGGE 289 Query: 395 RYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGF 454 R D+ L I V + A DPAF P++FD TR + +L F Sbjct: 290 RVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITRRPAP--------HLAF 341 Query: 455 GWGVRQCVGRRIAELEMTLFLIHILENFK 483 G+G QC+G+++A +E+ + + Sbjct: 342 GFGAHQCIGQQLARIELQIVFETLFRRLP 370 >3IVY-A nrPDB Length = 433 Score = 151 bits (380), Expect = 8e-37, Method: Composition-based stats. Identities = 54/363 (14%), Positives = 109/363 (30%), Gaps = 64/363 (17%) Query: 139 VLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDI 198 +L + + R ++ + P A+ L +Q + GSG FV + Sbjct: 116 MLNMDAPHHTRLRKII-SRGFTPRAVGRLHDELQERAQKIAAE----AAAAGSGDFVEQV 170 Query: 199 KEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLF 258 +L A + V +R K+FH S + Y Sbjct: 171 SCELPLQAIAGLLGVPQEDR-------------------GKLFHWSNEMTGNEDPEYAHI 211 Query: 259 RTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKAN 318 K + Y ++ + ++ + EK+ ++ Sbjct: 212 DPKASSAELIG----------YAMKMAEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFF 261 Query: 319 ITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKA 378 + + G TT ++ + A + Q L ++V + Sbjct: 262 VVMLAVAGNETTRNSITQGMMAFAEHPD-QWELYKKVRP-------------------ET 301 Query: 379 SIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTR 438 + E +R QR D L I V + + D F P F+ R Sbjct: 302 AADEIVRWATPVTAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILR 361 Query: 439 WLSKDKDLIHFRNLGFGW-GVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFN 497 + ++GFG G C+G +A + + L + ++ +++ I + + + Sbjct: 362 NPNP--------HVGFGGTGAHYCIGANLARMTINLIFNAVADHMP-DLKPISAPERLRS 412 Query: 498 LIL 500 L Sbjct: 413 GWL 415 >1Q5D-A nrPDB Length = 419 Score = 151 bits (380), Expect = 9e-37, Method: Composition-based stats. Identities = 81/424 (19%), Positives = 139/424 (32%), Gaps = 69/424 (16%) Query: 70 GSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAY 129 G F IE ++ PI+ G S + DV+ +F+ E R + Y Sbjct: 23 GYAEDPFPAIERLREATPIFYWDEGR--SWVLTRYHDVSAVFRDERFAVSREEWESSAEY 80 Query: 130 HRY-----YQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHK 184 K G+ + R ++N P I LL Q V L Sbjct: 81 SSAIPELSDMKKYGLFGLPPEDHARVRKLVN-----PSFTSRAIDLLRAEIQRTVDQLLD 135 Query: 185 RIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTS 244 Q V D E + A ++ V + + ++F A + Sbjct: 136 ARSGQEEFDVVRDYAEGIPMRAISALLKVPAE---------CDEKFRRFGSATARALGVG 186 Query: 245 VPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCL 304 + VP T+ + + + L + +L L Sbjct: 187 L----VPRVD-------------EETKTLVASVTEGLALLHGVLDERRRNPLENDVLTML 229 Query: 305 LKSE----KMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARR 360 L++E ++ +++ A + ++A G +TT + + + + RS E+++ E Sbjct: 230 LQAEADGSRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAE------ 283 Query: 361 QAEGDISKMLQMVPLLKASIKETLRLHPIS-VTLQRYPESDLVLQDYLIPAKTLVQVAIY 419 L++ ++ E LR I + R+ DL I +V + I Sbjct: 284 ------------PGLMRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIP 331 Query: 420 AMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHIL 479 + RD FS PD FD R S L +G G C G +A LE + + I Sbjct: 332 SALRDGTVFSRPDVFDVRRDTSAS--------LAYGRGPHVCPGVSLARLEAEIAVGTIF 383 Query: 480 ENFK 483 F Sbjct: 384 RRFP 387 >5HDI-A nrPDB Length = 404 Score = 149 bits (376), Expect = 3e-36, Method: Composition-based stats. Identities = 52/258 (20%), Positives = 88/258 (34%), Gaps = 26/258 (10%) Query: 227 NPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQ 286 + + L+ +L D + A + Y + Sbjct: 147 RLPMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGVALMELSGYIFEQF- 205 Query: 287 DLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLN 346 D N G L S ++ + + + A G +T+ L ++ +A + Sbjct: 206 DRAAADPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPD 265 Query: 347 VQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDY 406 +Q+ +R LL A I+ETLR P R+ + L Sbjct: 266 IQQQVR------------------ANPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGT 307 Query: 407 LIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRI 466 +PA + + + A RDPA F +P +F R K ++ FG G CVG + Sbjct: 308 ELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKG-------HISFGKGAHFCVGAAL 360 Query: 467 AELEMTLFLIHILENFKV 484 A LE + L +L+ V Sbjct: 361 ARLEARIVLRLLLDRTSV 378 >6CVC-A nrPDB Length = 433 Score = 148 bits (374), Expect = 5e-36, Method: Composition-based stats. Identities = 45/334 (13%), Positives = 99/334 (29%), Gaps = 39/334 (11%) Query: 178 FVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAV 237 H+R++ S F + + E ++ + + ++ A Sbjct: 117 LDDPRHQRLRSIVSRAFTPKVVARIEASVRERAHRLVAAMIENHPDGQADLVSEL---AG 173 Query: 238 YKMFHTSVPLLNVPPELYRLFRTKT-------WRDHVAAWDTIFNKAEK---YTEIFYQD 287 ++ +P E + T D +D + Y D Sbjct: 174 PLPLQIICDMMGIPEEDHEQIFHWTNVILGFGDPDLTTDFDEFLQVSMAIGGYATALADD 233 Query: 288 LRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNV 347 R ++ + E++ ++ ++ G TT + + ++R + Sbjct: 234 RRVNHHGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNAISHGMLALSRYPDE 293 Query: 348 QEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYL 407 + + L +++E +R V ++R D+ L+ Sbjct: 294 RAKWWSDFDG-----------------LAATAVEEIVRWASPVVYMRRTLSQDVDLRGTK 336 Query: 408 IPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGF-GWGVRQCVGRRI 466 + A V + + RD F+ P FD TR + +GF G G C+G + Sbjct: 337 MAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQ--------VGFGGGGAHFCLGANL 388 Query: 467 AELEMTLFLIHILENFKVEMQHIGDVDTIFNLIL 500 A E+ + + + + I Sbjct: 389 ARREIRVVFDELRRQMPDVVATEEPARLLSQFIH 422 >6M7L-A nrPDB Length = 404 Score = 147 bits (371), Expect = 1e-35, Method: Composition-based stats. Identities = 60/404 (14%), Positives = 116/404 (28%), Gaps = 83/404 (20%) Query: 86 GPIYREKL--GNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKK 143 GP+ R L G+ + + + V + GS + H+ P +L Sbjct: 48 GPLVRIPLEDGSAVHWFALGYDVVREVL---GSEKFDKRVIGTHFNHQEMALPGNLLQLD 104 Query: 144 SGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLF 203 + R ++ + ++ P + + D + + +G V ++E Sbjct: 105 PPEHTRLRRMVAP-AYSVRRMQALEPRVQAIVDDHLDTM------ASTGPPVEFLREVAG 157 Query: 204 HFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTW 263 A L +P + T Sbjct: 158 PMAARVAC----------------------------------EFLGIPLDDRGELIRLT- 182 Query: 264 RDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSE--KMLLEDVKANITE 321 H Y + R G+L + + + E++ Sbjct: 183 -AHRGGKRRRVLNGHAYLAYMRELAARLRRDPG-DGMLGMVARDHGADISDEELAGLCAV 240 Query: 322 MLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIK 381 ++ V T L + +LRE L + +++ Sbjct: 241 VMNSSVEQTESCLAAGTLLLLEHPEQFALLRE------------------RPELGEQAVE 282 Query: 382 ETLRLHPISVTL-QRYPESDLVLQDYLIPAKTLVQVAIYAMGR-DPAFFSSPDKFDPTRW 439 E +R + L R D+ + +I V ++ A R DPA D FD TR Sbjct: 283 EIVRYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAANRADPAL----DGFDITR- 337 Query: 440 LSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 R++ FG G+ C+G +A +E+ + ++ F Sbjct: 338 -------KESRHVAFGHGIHHCLGAPLARMELRIAFTTLVSRFP 374 >6G5O-A nrPDB Length = 399 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 44/300 (14%), Positives = 94/300 (31%), Gaps = 40/300 (13%) Query: 186 IKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSV 245 ++ + +E L E + + + ++ + A+ Sbjct: 87 VEPWFKRPLQAEYQEKLTAQISEIVEETLLKGSVEVVTDF----------ALRLQSRALT 136 Query: 246 PLLNVPPELYR----LFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGIL 301 LLN P + A N Y + Y +L Sbjct: 137 LLLNTPFSESETWISWGTHVFRSEGEALDGDKANILYHYIDEQIDRASENPGDDMYSVLL 196 Query: 302 YCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQ 361 + K+ E+VK + AGG +T + + +A E LR+E Sbjct: 197 NSEFEGRKLTKEEVKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRKE------- 249 Query: 362 AEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAM 421 + +++E +R + R D + ++ + A + + + + Sbjct: 250 -----------PEITGRAVEEMIRYFSPLTQMGRVVTEDTHVCEHAVKADSRISLCWASA 298 Query: 422 GRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILEN 481 RD A F +P++ R ++ ++GFG+ C+G A + + L + + Sbjct: 299 NRDAAVFENPNEIVLDRKVNP--------HVGFGFSHHNCLGATHARQILKILLQTLAQK 350 >5HIW-A nrPDB Length = 398 Score = 139 bits (350), Expect = 3e-33, Method: Composition-based stats. Identities = 62/360 (17%), Positives = 120/360 (33%), Gaps = 59/360 (16%) Query: 139 VLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPL-LNPVSQDFVSLLHKRIKQQGSGKFVGD 197 ++ + R + N V++P I + + PV++ V L ++ + + F Sbjct: 72 LVTLGGEAHTRMRRLFNA-VLSPRVISRYEEATVTPVARRVVERLVRKERAELFDDFAIS 130 Query: 198 IKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRL 257 + +T+ +FG + E DA+ + SV + P Sbjct: 131 MPMG--------VTSALFGLPEERIAEN---------DALIRKMIRSVVMPQDPV----- 168 Query: 258 FRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKA 317 VA + E + I ++ +E + Sbjct: 169 --------VVAEGRSAHAAMEAQLREIAEREVAHPSDTLLGEIARAIVAEGLGGVEACEG 220 Query: 318 NITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLK 377 + ++ G TTS L L + + LR Q LL Sbjct: 221 VVLTLILGSYETTSWMLANLLVALLAHPDAMNQLR------------------QQPSLLP 262 Query: 378 ASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPT 437 +I+E+ R + + R+ E + + + A T++ +++ A D + P+ FD Sbjct: 263 QAIEESTRWCSSAAGIVRFVEREATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDIH 322 Query: 438 RWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFN 497 R L FG G+ CVG +A +E + + +LE F ++ V F+ Sbjct: 323 R--------RPVGMLNFGGGLHYCVGAPLARMEARVGVSLLLERFPA-LRADPTVQPTFS 373 >2UUQ-A nrPDB Length = 414 Score = 139 bits (350), Expect = 3e-33, Method: Composition-based stats. Identities = 60/443 (13%), Positives = 127/443 (28%), Gaps = 106/443 (23%) Query: 71 SQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYH 130 S E + P+YR + +++ P+ + + + + W A Sbjct: 13 SHEFQLATAETWPNPWPMYRALRDHDPVHHVVPPQRPEYDYYVLSRHAD-----VWSAAR 67 Query: 131 RYYQ--------------KPIGV-----LFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLL 171 + + IG+ + + + L + P ++ + Sbjct: 68 DHQTFSSAQGLTVNYGELEMIGLHDTPPMVMQDPPVHTEFRKLVSRGFTPRQVE----TV 123 Query: 172 NPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQ 231 P + FV ++++ G G V ++ + L Sbjct: 124 EPTVRKFVVERLEKLRANGGGDIVTELFKPLPSMV------------------------- 158 Query: 232 KFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEI------FY 285 L VP E + F W + A + + + ++ Sbjct: 159 ------------VAHYLGVPEEDWTQFD--GWTQAIVAANAVDGATTGALDAVGSMMAYF 204 Query: 286 QDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLA------GGVNTTSMTLQWHLY 339 L + + L+ + D ++ + GG +T + L + Sbjct: 205 TGLIERRRTEPADDAISHLVAAGVGADGDTAGTLSILAFTFTMVTGGNDTVTGMLGGSMP 264 Query: 340 EMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPES 399 + R + + +L ++ + +++E LRL L R Sbjct: 265 LLHRRPDQRRLLLDDPEG------------------IPDAVEELLRLTSPVQGLARTTTR 306 Query: 400 DLVLQDYLIPAKTLVQVAIYAMGRDPAFF-SSPDKFDPTRWLSKDKDLIHFRNLGFGWGV 458 D+ + D IPA V + + RD + + D TR L F G Sbjct: 307 DVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTR--------CPRNILTFSHGA 358 Query: 459 RQCVGRRIAELEMTLFLIHILEN 481 C+G A ++ + L +L Sbjct: 359 HHCLGAAAARMQCRVALTELLAR 381 >2X9P-A nrPDB Length = 404 Score = 139 bits (350), Expect = 3e-33, Method: Composition-based stats. Identities = 67/427 (15%), Positives = 129/427 (30%), Gaps = 78/427 (18%) Query: 78 HIENFQKYGPIYREKL-GNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKP 136 + Q GPI+R + E+ + ++ L E D P Y R Sbjct: 31 LLRALQDRGPIHRVRTPAGDEAWLVTRHAELKQLLHDERIGRTHPDPPSAAQYVRSPFLD 90 Query: 137 IGVLFKKSGTWKKDR---VVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGK 193 + + + + ++ L T + + + P + + +LL I Q G Sbjct: 91 LLISDADAESGRRQHAETRRLLTPLFSARRVLEMQPKVEEAA---DTLLDAFIAQGPPGD 147 Query: 194 FVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPE 253 G++ ++ VPP+ Sbjct: 148 LHGELTVPFALTVL-------------------------------------CEVIGVPPQ 170 Query: 254 LYRLFRTKTWRDHVAAWDTIFNKAEKYTEIF--YQDLRRKTEFRNYPGILYCLLKSEKML 311 R T +A D ++F L P I+ L ++ Sbjct: 171 --RRAELTTLLAGIAKLDDREGAVRAQDDLFGYVAGLVEHKRAEPGPDIISRL-NDGELT 227 Query: 312 LEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQ 371 + V +L G+++ + + + +A + + L Sbjct: 228 EDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPD------------------QRAAALA 269 Query: 372 MVPLLKASIKETLRLHPI--SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFS 429 ++ +++E LR SV RY D+ I A LV + D F+ Sbjct: 270 DPDVMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAFT 329 Query: 430 SPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHI 489 P++FD R + +L FG G+ C+G +A LE+ + E++ Sbjct: 330 GPEEFDAARTPNP--------HLTFGHGIWHCIGAPLARLELRTMFTKLFTRLP-ELRPE 380 Query: 490 GDVDTIF 496 V+ + Sbjct: 381 LPVEQLR 387 >2NZA-A nrPDB Length = 413 Score = 139 bits (350), Expect = 3e-33, Method: Composition-based stats. Identities = 56/309 (18%), Positives = 102/309 (33%), Gaps = 42/309 (13%) Query: 183 HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFH 242 H R+++ +G F + L A E + ++ G + E ++ ++ Sbjct: 104 HNRLRRAVAGAFTVGATKRLRPRAQEILDGLVDGI---LAEGPPADLVERVLEPF--PIA 158 Query: 243 TSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQ------DLRRKTEFRN 296 ++ VP R +W + + AE+ Y R +E + Sbjct: 159 VVSEVMGVPAADRE--RVHSWTRQIISTSGGAEAAERAKRGLYGWITETVRARAGSEGGD 216 Query: 297 YPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVL 356 +L + ++ + + GG + + LY + + +RE Sbjct: 217 VYSMLGAAVGRGEVGETEAVGLAGPLQIGG-EAVTHNVGQMLYLLLTRRELMARMRE--- 272 Query: 357 NARRQAEGDISKMLQMVPLLKASIKETLRL--HPISVTLQRYPESDLVLQDYLIPAKTLV 414 ++ E LR H SV L R D+ + I A V Sbjct: 273 ---------------RPGARGTALDELLRWISHRTSVGLARIALEDVEVHGTRIAAGEPV 317 Query: 415 QVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLF 474 V+ A RDP F PD+ D R + +L +G G C G +A ++ L Sbjct: 318 YVSYLAANRDPDVFPDPDRIDLDRDPNP--------HLAYGNGHHFCTGAVLARMQTELL 369 Query: 475 LIHILENFK 483 + +LE Sbjct: 370 VDTLLERLP 378 >6GII-A nrPDB Length = 479 Score = 139 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 53/424 (12%), Positives = 132/424 (31%), Gaps = 61/424 (14%) Query: 100 YIIHPEDVAHLFKFEGSYPERYDIPPWL---AYHRYYQKPIGVLFK-----KSGTWKKDR 151 + + + +F+ ++ + + A R + G F + +R Sbjct: 103 VVTRYDTIKQIFRDPVTFSPSNVLQSFAQPSAEVRQVLERYGYAFNRTLVNEDEPMHLER 162 Query: 152 VVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESIT 211 + E A E + P++ + + R + D+ + + ++ Sbjct: 163 RRVLMEPFASEHLAEHEPMVRELVR--------RAVNRFIDTGRADLVDQMIWEVPFTVA 214 Query: 212 NVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWD 271 G +++ + ++F A +V P +L +T Sbjct: 215 LHFLG-----VDDDDREKMRRFAIA------HTVNAFGRPSPEEQLAVAETVGQFWQFCG 263 Query: 272 TIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTS 331 + K + + + + YP ++ + + + ++ TT Sbjct: 264 EVLEKMRRTADGPGWMRYSIRQQKLYPDVVTDSY---------LHSMMQAIIVAAHETTV 314 Query: 332 MTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISV 391 L + V + L+ A+ +E LR + Sbjct: 315 FATTNALKTLLEHETVWREI------------------CADPSLIPAAAEECLRYNGPVA 356 Query: 392 TLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRN 451 +R ++ ++ +P + + + + D A F P+ FD R + + + Sbjct: 357 GWRRRTTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFFDIGRSNASE-------H 409 Query: 452 LGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFR 511 L FG+G QC+GR + +EM + + + D + N+ + +++ + Sbjct: 410 LNFGYGAHQCLGRNLGRMEMQIMIEELSRRLPHMRLAEQRFDYLHNVSFRAPRHLWVEWD 469 Query: 512 PFNQ 515 P Sbjct: 470 PAQN 473 >3WEC-A nrPDB Length = 419 Score = 135 bits (340), Expect = 4e-32, Method: Composition-based stats. Identities = 52/332 (15%), Positives = 104/332 (31%), Gaps = 52/332 (15%) Query: 183 HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFH 242 H R++ S F + + ++ + L + V+ A+ F V Sbjct: 108 HTRLRGLVSDAFTRSTTTSMDDIVLSAASSAVRH--LEHCTDAVSEVAEPFPVEVLS--- 162 Query: 243 TSVPLLNVPPELYRLFRTKTWRDHVAAW------------DTIFNKAEKYTEIFYQDLRR 290 +L +P + F W + VA D E+ + F Sbjct: 163 ---SILGIPDKDRGRFS--EWSNLVAGVLDINFAIPKEVADRRSAAIEESIDYFRTLATS 217 Query: 291 KTEFRNYPGILYCLLKS-EKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQE 349 L + +++ ++++ A + G TTS T+ L +R + E Sbjct: 218 GNAPEGLVRRLSEVSHGGDQLSVDEIAATCLLITVAGQETTSNTIGNMLITFSRHADQFE 277 Query: 350 MLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIP 409 +R ++ ++ E LR P + R D + I Sbjct: 278 QVR------------------ANPQFIENAVAEVLRFEPPAHEAGRIALEDCEVSGANIT 319 Query: 410 AKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAEL 469 V V + + R D F TR +L +G G+ C+G +A Sbjct: 320 KGDAVMVLLASGNR--EAVERGDTFSVTR--------PDVSSLSYGRGIHHCLGSALANS 369 Query: 470 EMTLFLIHILENFKVEMQHIGDVDTIFNLILT 501 + FL + + ++ ++ ++ + L Sbjct: 370 MLQHFLRELSQRYR-SIEVAEPINYKPGMGLR 400 >6G71-A nrPDB Length = 405 Score = 135 bits (340), Expect = 4e-32, Method: Composition-based stats. Identities = 48/222 (21%), Positives = 85/222 (38%), Gaps = 32/222 (14%) Query: 268 AAWDTIFNKAEKYTEIFYQDLRRKTEFRNY---PGILYCLLKSE--KMLLEDVKANITEM 322 ++ KA++ ++ L ++ + +L LL+S +M LE +++NI Sbjct: 174 PDDPDVWAKAKQSSDEIDAALEEMIQWHSGRPGDSLLSYLLRSADYQMPLESIRSNIKMT 233 Query: 323 LAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKE 382 + GG+N L + S E++ L+ L A +E Sbjct: 234 IGGGLNEPRDVLGVSTLALLSSSKQLELV------------------LRDPKLWGAVFEE 275 Query: 383 TLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSK 442 ++R + R D L Y IP + + I + RD + +S PD+FD R Sbjct: 276 SIRWVAPIGMVPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRFDIERGSEA 335 Query: 443 DKDLIHFRNLGFGWGVRQCVGRRIAELEMT-LFLIHILENFK 483 +L FG GV C+G A ++ + L + K Sbjct: 336 --------HLAFGKGVHVCLGAWAARSQVADVGLPALFSRLK 369 >2WIY-A nrPDB Length = 394 Score = 135 bits (340), Expect = 4e-32, Method: Composition-based stats. Identities = 56/306 (18%), Positives = 99/306 (32%), Gaps = 30/306 (9%) Query: 183 HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVN-----PEAQKFIDAV 237 H +++Q + F + + E + +++ G G + E P + Sbjct: 87 HTVLRRQTNKWFTPKLVDGWVRTTRELVGDLLDGVEAGQVIEARRDLAVVPTHVTMARVL 146 Query: 238 YKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNY 297 + ++ E + + V F +D +R Sbjct: 147 QLPEDDADAVMEAMFEAMLMQSAEPADGDVDRAAVAFGYLSARVAEMLED-KRVNPGDGL 205 Query: 298 PGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLN 357 L ++ ++ + A I A G + + AR V Sbjct: 206 ADSLLDAARAGEITESEAIATILVFYAVGHMAIGYLIASGIELFARRPEV---------- 255 Query: 358 ARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVA 417 + A I E +R+ P ++ R+P D+ + LI A + ++ Sbjct: 256 --------FTAFRNDESARAAIINEMVRMDPPQLSFLRFPTEDVEIGGVLIEAGSPIRFM 307 Query: 418 IYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIH 477 I A RDP F PD FD TR + RNL FG G C G+ I+ E T Sbjct: 308 IGAANRDPEVFDDPDVFDHTRPPAA------SRNLSFGLGPHSCAGQIISRAEATTVFAV 361 Query: 478 ILENFK 483 + E ++ Sbjct: 362 LAERYE 367 >5L1U-A nrPDB Length = 401 Score = 134 bits (338), Expect = 6e-32, Method: Composition-based stats. Identities = 53/273 (19%), Positives = 89/273 (32%), Gaps = 31/273 (11%) Query: 217 ERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNK 276 E L L + P + + LL VP F + + Sbjct: 125 ELLDQLAASAPPVDLHRVLSFRLPTMVVCDLLGVPLADRERFGQWARGTFDQSDNEHSAN 184 Query: 277 AEKYTEIFYQDLRRKTEFRNYPGILYCLL--KSEKMLLEDVKANITEMLAGGVNTTSMTL 334 + + +L + IL L+ K + D+ +L G TT + + Sbjct: 185 TFQQVVDYMLELVARKRVEPGDDILSELIAEKDGALSDADIAHLGNAVLLFGYETTIVRI 244 Query: 335 QWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRL----HPIS 390 + R+ + L E+ L A+++E LRL + Sbjct: 245 DLGTLLLLRNPVQRAQLAED------------------PGLAPAAVEEILRLGVGGKGSN 286 Query: 391 VTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFR 450 + RY D+ + + +I V +AI A D F FD TR + Sbjct: 287 ALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGGLFDLTR-------VRPRS 339 Query: 451 NLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 +L FG G R C+GR +A +E+T + Sbjct: 340 HLAFGHGARHCIGRTLARIELTAVFERLFRRLP 372 >4FB2-A nrPDB Length = 398 Score = 134 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 66/408 (16%), Positives = 136/408 (33%), Gaps = 55/408 (13%) Query: 117 YPERYDIPPWLAYHRYYQK----PIGVLFKKSGTW------KKDRVVLNTEVMAPEA--I 164 P D P + + PIG G W + V+ NT+ + + Sbjct: 13 TPLGPDGTPHAFFEALRDEAETTPIGWSEAYGGHWVVAGYKEIQAVIQNTKAFSNKGVTF 72 Query: 165 KNFI-PLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLE 223 + + +HK+ +Q + F + + LF TN + R+ + E Sbjct: 73 PRYETGEFELMMAGQDDPVHKKYRQLVAKPFSPEATD-LFTEQLRQSTNDLIDARIELGE 131 Query: 224 ETVNPEAQKFIDAVYKMFHTSVPLLNVPPEL----YRLFRTKTWRDHVAAWDTIFNKAEK 279 I A LL +PPE R T ++ IF + Sbjct: 132 GDAATWLANEIPARLTAI-----LLGLPPEDGDTYRRWVWAITHVENPEEGAEIFAELVA 186 Query: 280 YTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLY 339 + + R ++ + E + +D+ T +L GG++ T+ L + Sbjct: 187 HARTLIAERRTNPGNDIMSRVIMSKIDGESLSEDDLIGFFTILLLGGIDNTARFLSSVFW 246 Query: 340 EMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPES 399 +A + ++ L + L+ ++ E LR + ++ + R Sbjct: 247 RLAWDIELRRRL------------------IAHPELIPNAVDELLRFYGPAM-VGRLVTQ 287 Query: 400 DLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVR 459 ++ + D + + RD + F SPD R + R+L G G+ Sbjct: 288 EVTVGDITMKPGQTAMLWFPIASRDRSAFDSPDNIVIERTPN--------RHLSLGHGIH 339 Query: 460 QCVGRRIAELEMTLFLIHILEN---FKVEM--QHIGDVDTIFNLILTP 502 +C+G + +E + + L+ F ++ + + + ++ P Sbjct: 340 RCLGAHLIRVEARVAITEFLKRIPEFSLDPNKECEWLMGQVAGMLHVP 387 >1WIY-A nrPDB Length = 389 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 73/435 (16%), Positives = 140/435 (32%), Gaps = 72/435 (16%) Query: 69 KGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLA 128 K Q+ + + + P L I PE V EG+ + + A Sbjct: 14 KDLQQDPLAVLLEWGRAHPRLFLPLPRFPLALIFDPEGVEGALLAEGTTKATF---QYRA 70 Query: 129 YHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQ 188 R + G+L +WK+ R L + P++++ + + + F + Sbjct: 71 LSRLTGR--GLLTDWGKSWKEARKAL-KDPFLPKSVRGYREAMEEEAWAFFGEWRGEER- 126 Query: 189 QGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLL 248 D+ ++ + + +FG+ L A+ + A+ ++ Sbjct: 127 --------DLDHEMLALSLRLLGRALFGKPLS------PSLAEHALKALDRIMA------ 166 Query: 249 NVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSE 308 +T + K Y++ Sbjct: 167 ------------QTRSPLALLDLAAEARFRKDRGALYREAEALIVHPPLS---------- 204 Query: 309 KMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISK 368 + E + +L G T + L W ++ + Q+ + E A Sbjct: 205 HLPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRVAESEEAALAA------- 257 Query: 369 MLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFF 428 +E LRL+P + L R E L+L + +P T + ++ Y R +F Sbjct: 258 -----------FQEALRLYPPAWILTRRLERPLLLGEDRLPQGTTLVLSPYVTQR--LYF 304 Query: 429 SSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQH 488 + F P R+L++ R FG G R C+GR A LE + L F+++ Sbjct: 305 PEGEAFQPERFLAERGT-PSGRYFPFGLGQRLCLGRDFALLEGPIVLRAFFRRFRLDPLP 363 Query: 489 IGDVDTIFNLILTPD 503 V + + L P+ Sbjct: 364 FPRV--LAQVTLRPE 376 >3OO3-A nrPDB Length = 384 Score = 132 bits (331), Expect = 4e-31, Method: Composition-based stats. Identities = 56/355 (15%), Positives = 110/355 (30%), Gaps = 43/355 (12%) Query: 159 MAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGER 218 M P + LL + Q + H R+++ + + E L E + E Sbjct: 63 MRPVDDEADRALLPGILQAYDPPDHTRLRRTVAPAYSARRMERLRPRIEEIV-----EEC 117 Query: 219 LGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAE 278 L E P A + + L VP + + + Sbjct: 118 LDDFESVGAPVDFVRHAAWPIPAYIACEFLGVPRDDQAELSRMIRESRESRLPRQRTLSG 177 Query: 279 KYTEIFYQDLRRKTEFRNYPGILYCLL--KSEKMLLEDVKANITEMLAGGVNTTSMTLQW 336 + + L G++ ++ ++ E++ L + L Sbjct: 178 LGIVNYTKRLTSGKRRDPGDGMIGVIVREHGAEISDEELAGLAEGNLIMAAEQMAAQLAV 237 Query: 337 HLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTL-QR 395 + + + +LRE L+ ++ +E LR I R Sbjct: 238 AVLLLVTHPDQMALLRE------------------KPELIDSATEEVLRHASIVEAPAPR 279 Query: 396 YPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFG 455 +D+ + I A ++ ++ A R P D+FD TR ++ FG Sbjct: 280 VALADVRMAGRDIHAGDVLTCSMLATNRAP-----GDRFDITR--------EKATHMAFG 326 Query: 456 WGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVF 510 G+ C+G +A L++ + L ++ F + + D F P +P Sbjct: 327 HGIHHCIGAPLARLQLRVALPAVVGRFPSLRLAVPEEDLRF----KPGRPAPFAV 377 >6BLD-A nrPDB Length = 419 Score = 128 bits (320), Expect = 8e-30, Method: Composition-based stats. Identities = 56/375 (14%), Positives = 113/375 (30%), Gaps = 60/375 (16%) Query: 139 VLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDI 198 L K R L + P ++ + ++ V L G FV Sbjct: 102 FLAMDPPRHTKLRK-LVSAAFTPRQVRRIEDSIKINAKGIVDELRM---AGGGVDFVEHC 157 Query: 199 KEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPL-LNVPPELYRL 257 ++L + + +R ++ A + + P LN L L Sbjct: 158 AKELPIRTLSDMVGIPEADR------------ERVAHAADALVSWADPRYLNGREPLAVL 205 Query: 258 FRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKA 317 F + + VAA + R + + ++ + +++ DV A Sbjct: 206 FENQMYLHQVAA-------------SLAAERRDRPGDDLFSALVNAEVDGDRLADADVAA 252 Query: 318 NITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLK 377 + G +TT T+ L + + + L + Sbjct: 253 FFVLLAVAGNDTTRQTISHGLKALTDFPSQKAWLLADFDTRIG----------------- 295 Query: 378 ASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPT 437 +++E +R +T +R +D L LI A V + + D F P++ D + Sbjct: 296 TAVEELVRWATPVMTFRRTAAADFELGGQLIRAGEKVVMFYASGNWDEDAFCHPERLDLS 355 Query: 438 RWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHI--GDVDTI 495 R + C+G +A ++ +L V++ I GD + Sbjct: 356 RSPNPHVGFGGGGVH-------FCLGAHLARAQLRAIFGELL----VQLPDIQAGDPVYV 404 Query: 496 FNLILTPDKPIFLVF 510 + + + F Sbjct: 405 PGNFVHAIRSMPCTF 419 >5KYO-A nrPDB Length = 430 Score = 126 bits (317), Expect = 2e-29, Method: Composition-based stats. Identities = 70/417 (16%), Positives = 130/417 (31%), Gaps = 38/417 (9%) Query: 104 PEDVAHLFKFEGSYPERYDIPP-WLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAP- 161 P D F PE D W R P+ G W R L VM+ Sbjct: 40 PADRVFDFDIYRDVPEGLDFHQSWREIMRQAPHPLMWTPHNGGHWVALRSDLAETVMSDF 99 Query: 162 EAIKNFIPLLNPVSQDFV-SLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLG 220 E N L+ + L+ + F + E+L I V+ + Sbjct: 100 ERFSNHTVLVPKETAGEAYRLIPLSLDPPEHRPFRSLLNENLGPKPLRPIEQVVTDLAVS 159 Query: 221 MLEETVNPEAQKFIDAVYKMFHTSV--PLLNVP----PELYRLFRTKTWRDHVAAWDTIF 274 ++E F + + ++++P P+L L T D D + Sbjct: 160 LIEGFRPKGRCNFTHEFAEQLPVRIFMRIVDLPVEDLPKLKHLADQYTRPDGSIPLDDVT 219 Query: 275 NKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTL 334 + +Y + R K ++ + + + + ++L GG++T L Sbjct: 220 KQFREYLRPVIEARRIKPGEDMISRMINGEVGGRPLTDIEAENICIQVLVGGLDTVVNML 279 Query: 335 QWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQ 394 + +A+ ++ + L+ ++ E R P+ + Sbjct: 280 GFTFSHLAKDHALRRAIA------------------ADPSLIDDALLEFFRRFPVVSS-A 320 Query: 395 RYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGF 454 R D + L+ A +V + D A P +F R ++ F Sbjct: 321 REVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDPLEFRLGR--------KARQHSTF 372 Query: 455 GWGVRQCVGRRIAELEMTLFLIHILENF-KVEMQHIGDVDTIFNLILTPDKPIFLVF 510 G G C G +A +EM + L + ++ + N I+ KP L + Sbjct: 373 GKGSHTCPGAHLARMEMKVVLREWFARIPEFRIEDDAPL-RYSNGIVGSVKPFVLEW 428 >2RCM-A nrPDB Length = 495 Score = 121 bits (303), Expect = 8e-28, Method: Composition-based stats. Identities = 65/475 (13%), Positives = 149/475 (31%), Gaps = 54/475 (11%) Query: 38 AGISTKTPRPYSEIPSPGDNGWLN-LYHFWREKGSQRIHFRHIENFQKYGP-IYREKLGN 95 A + P IP + + W Q +KY +YR + Sbjct: 17 ATRTGSKDLPIRNIPGNYGLPIVGPIKDRWDYFYDQGAEEFFKSRIRKYNSTVYRVNMPP 76 Query: 96 -------LESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWK 148 + V ++ + LF + + ++ + + K Sbjct: 77 GAFIAENPQVVALLDGKSFPVLFDVDKVEKKDLLTGTYMPSTELTGGYRILSYLDPSEPK 136 Query: 149 KDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFE 208 +++ + + P + L K + +G F G AF Sbjct: 137 HEKLKNLLFFLLKSSRNRIFPEFQATYSELFDSLEKELSLKGKADFGGSSDG----TAFN 192 Query: 209 SITNVMFG---ERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPEL--YRLFRTKTW 263 + +G + + + + ++ + +P + P + + L Sbjct: 193 FLARAFYGTNPADTKLKADAPGLITKWVLFNLHPLLSIGLPRVIEEPLIHTFSLPPALVK 252 Query: 264 RDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEML 323 D+ ++ A + + D + +L+ + ++ + N+ + + Sbjct: 253 SDYQRLYEFFLESAGEI--LVEADKLGISREEATHNLLFATCFNTWGGMKILFPNMVKRI 310 Query: 324 A-GGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDIS-KMLQMVPLLKASIK 381 G V L EE+ + + G+++ ++ + L K+ + Sbjct: 311 GRAGH------------------QVHNRLAEEIRSVIKSNGGELTMGAIEKMELTKSVVY 352 Query: 382 ETLRLHPISVTLQRYPESDLVLQDYL----IPAKTLVQVAIYAMGRDPAFFSSPDKFDPT 437 E LR P + DLV++ + + A ++ RDP F D+F P Sbjct: 353 ECLRFEPPVTAQYGRAKKDLVIESHDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPE 412 Query: 438 RWLSKDKDLIHFRNLGFGWGV---------RQCVGRRIAELEMTLFLIHILENFK 483 R++ ++ + + R++ + G +QC G+ L LF+I I + Sbjct: 413 RFVGEEGEKLL-RHVLWSNGPETETPTVGNKQCAGKDFVVLVARLFVIEIFRRYD 466 >5HH3-A nrPDB Length = 397 Score = 121 bits (302), Expect = 9e-28, Method: Composition-based stats. Identities = 46/305 (15%), Positives = 93/305 (30%), Gaps = 37/305 (12%) Query: 183 HKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFH 242 H R+++ + F + + + + +F +V Sbjct: 99 HTRLRRMVAPAFAVRRMQKFQPQVERVVQDSLDAIEA---LGGPVDFVPRFGWSVATT-- 153 Query: 243 TSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILY 302 + L +P + A + + +T + Sbjct: 154 ATCDFLGIPRDDQADLARSLHASRTERSGKRRTAAGNKFMTYMNKMTARTRRDPGDDMFG 213 Query: 303 CLLK--SEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARR 360 +++ +++ ++ ++ G + + L + MA +LRE+ Sbjct: 214 VVVREYGDEITDAELTGVAAFVMGAGADQVARFLAAGAWLMADDPEQFALLREKPDTV-- 271 Query: 361 QAEGDISKMLQMVPLLKASIKETLRLHPI-SVTLQRYPESDLVLQDYLIPAKTLVQVAIY 419 + E +R T R D+ + D+LI A V ++ Sbjct: 272 ----------------PDWLDEVIRYLTTDEKTHPRVATDDVRIGDHLIKAGDTVTCSLL 315 Query: 420 AMGRDPAFFSSP-DKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHI 478 A R F P D+FD TR + +L FG G+ C+GR +AEL + + Sbjct: 316 AANR--RNFPRPEDRFDITR--------VRPEHLAFGHGIHHCLGRSLAELVFRTAIPAL 365 Query: 479 LENFK 483 F Sbjct: 366 AHRFP 370 >2IJ7-A nrPDB Length = 396 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 53/350 (15%), Positives = 111/350 (31%), Gaps = 40/350 (11%) Query: 142 KKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKED 201 + + R + A N + + V + ++ +++ Sbjct: 50 LCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAITPKAPG- 108 Query: 202 LFHFAFESITNVMFGERLGMLEETVNPEAQK-FIDAVYKMFHTSVPLLNVPPELYRLFRT 260 L F ++ +++ ++ E + + F D + H V L +P E Sbjct: 109 LEQFLRDTANSLLD----NLITEGAPADLRNDFADPLATALHCKV--LGIPQEDGPKLFR 162 Query: 261 KTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEK-----MLLEDV 315 +++ D I + G++ L + K + +++ Sbjct: 163 SLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDEL 222 Query: 316 KANI-TEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVP 374 A I GV +T L L + + ++ +L E Sbjct: 223 FATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHE------------------KPE 264 Query: 375 LLKASIKETLRLH-PISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDK 433 L+ A ++E LR++ + L R +D+ + D L+ LV V + DP F +P Sbjct: 265 LIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGS 324 Query: 434 FDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFK 483 + R +L FG G C G + + + +L+ Sbjct: 325 IELDR-------PNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMP 367 >3BUJ-A nrPDB Length = 397 Score = 119 bits (298), Expect = 3e-27, Method: Composition-based stats. Identities = 60/336 (17%), Positives = 110/336 (32%), Gaps = 40/336 (11%) Query: 149 KDRVVLNTEVMAPEAIKNF--IPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFA 206 R VL E A I+ F + + + V + + G+ G + A Sbjct: 43 DVRAVLGDERFARTGIRRFWTDLVGPGLLAEIVGDIILFQDEPDHGRLRGVVGPAFSPSA 102 Query: 207 FESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFH--TSVPLLNVPPELY----RLFRT 260 + V+ G +L + A +D + + LL +P + R R Sbjct: 103 LRRLEPVIAGTVDDLLRPALARGAMDVVDELAYPLALRAVLGLLGLPAADWGAVGRWSRD 162 Query: 261 KTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPG---ILYCLLKSEK---MLLED 314 A + F + R R G +L +L + M + Sbjct: 163 VGRTLDRGASAEDMRRGHAAIAEFADYVERALARRRREGGEDLLALMLDAHDRGLMSRNE 222 Query: 315 VKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVP 374 + + + + G T + + + + + ++LR + Sbjct: 223 IVSTVVTFIFTGHETVASQVGNAVLSLLAHPDQLDLLR------------------RRPD 264 Query: 375 LLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKF 434 LL +++E LR P + R + D+ L+ + +V V A RDP + PD F Sbjct: 265 LLAQAVEECLRYDPSVQSNTRQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDF 324 Query: 435 DPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELE 470 D R + FG G+R C+G +A + Sbjct: 325 DIERDPVPS--------MSFGAGMRYCLGSYLARTQ 352 >5D3U-A nrPDB Length = 427 Score = 115 bits (288), Expect = 4e-26, Method: Composition-based stats. Identities = 48/294 (16%), Positives = 89/294 (30%), Gaps = 48/294 (16%) Query: 236 AVYKMFHTSVPLLNVPPELYRLFRTKT---------WRDHVAAWDTIFNKAEKYTEIFYQ 286 A ++V VP E + +D + I K + Sbjct: 164 AAELPVRSAVHAFGVPEEDLGFLIPRVNTIMTYFSGPKDQPVTQEIILEKLTD-LHTYAS 222 Query: 287 DLRRKTEFRNYPGILYCLLKSE---------KMLLEDVKANITEMLAGGVNTTSMTLQWH 337 +L + + P + L + + + + + A TT +L Sbjct: 223 ELLQGMRGKVLPDTVIARLAAAQDGLTETTPEQTVHQLALVFIALFAP---TTPGSLSSG 279 Query: 338 LYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYP 397 AR+ E + + E LR + + R Sbjct: 280 TLAFARNPRQVERFLADQACV------------------DNTANEVLRYNASNQFTWRVA 321 Query: 398 ESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWG 457 D+ + I A + + + + RD F P+ FD R R+L FG G Sbjct: 322 AKDVEMGGVRIEAGQTLALFLGSANRDANMFERPNDFDLDR-------PNSARHLSFGQG 374 Query: 458 VRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFR 511 V C+ ++ L++ F + +L F ++ G+ NL + + L R Sbjct: 375 VHACLAAQLISLQLKWFYVALLNRFP-GIRTAGEPIWNENLEFRSLRSLPLSLR 427 >2QBO-A nrPDB Length = 421 Score = 114 bits (286), Expect = 6e-26, Method: Composition-based stats. Identities = 60/415 (14%), Positives = 122/415 (29%), Gaps = 41/415 (9%) Query: 110 LFKFEGSYPERYDI---PPWLAYHRYYQKPIGVLFKK-SGTWKKDRVVLNTEVMAP-EAI 164 +F F+ P W P V + G W R L E Sbjct: 24 VFDFDMYNPSNLSAGVQEAWAVLQE-SNVPDLVWTRCNGGHWIATRGQLIREAYEDYRHF 82 Query: 165 KNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEE 224 + P + + + + + +F + + + + N + ++E Sbjct: 83 SSECPFIPREAGEAYDFIPTSMDPPEQRQFRALANQVVGMPVVDKLENRIQELACSLIES 142 Query: 225 TVNPEAQKFIDAVYKMFHTSVPLL--NVPPELYR----LFRTKTWRDHVAAWDTIFNKAE 278 F + + F + +L +P E L T D + Sbjct: 143 LRPQGQCNFTEDYAEPFPIRIFMLLAGLPEEDIPHLKYLTDQMTRPDGSMTFAEAKEALY 202 Query: 279 KYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHL 338 Y + R+K + + + ++ K +L G++T L + + Sbjct: 203 DYLIPIIEQRRQKPGTDAISIVANGQVNGRPITSDEAKRMCGLLLVVGLDTVVNFLSFSM 262 Query: 339 YEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPE 398 +A+S ++ L E + A+ +E LR + R Sbjct: 263 EFLAKSPEHRQELIERPER------------------IPAACEELLRRFSLVAD-GRILT 303 Query: 399 SDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGV 458 SD + + + G D + P D +R + FG G Sbjct: 304 SDYEFHGVQLKKGDQILLPQMLSGLDERENACPMHVDFSR--------QKVSHTTFGHGS 355 Query: 459 RQCVGRRIAELEMTLFLIHILENF-KVEMQHIGDVDTIFNLILTPDKPIFLVFRP 512 C+G+ +A E+ + L L + + + I++ + + LV+ P Sbjct: 356 HLCLGQHLARREIIVTLKEWLTRIPDFSIAPGAQIQHK-SGIVSGVQALPLVWDP 409 >5EX8-A nrPDB Length = 424 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 51/361 (14%), Positives = 103/361 (28%), Gaps = 71/361 (19%) Query: 143 KSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDL 202 + R ++ + ++ F P + + QD + + D Sbjct: 122 DPPEHTRLRRMVVP-AFSHRRMQKFRPRVEQIVQDSLDTIESL-------GGPVDFVPHF 173 Query: 203 FHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKT 262 T G + D ++ Sbjct: 174 GWAIATPATCDFLGIPRDDQADLARILLASRTD-------------------------RS 208 Query: 263 WRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEM 322 + AA + +++ R+ + GI+ + + ++ + Sbjct: 209 DKRRTAAGNKFMTYMKQHV-----AQSRRGSGDDLFGIVGRE-NGDAITDAELTGVAAFV 262 Query: 323 LAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKE 382 + + + L + M +LRE+ + E Sbjct: 263 MGAAADQVARLLAAGAWLMVEQPAQFALLREKPETV------------------PEWLDE 304 Query: 383 TLRLHPI-SVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLS 441 T+R T R D+ + + L+ A V ++ A R P + S+ D+FD TR Sbjct: 305 TMRYLTTDEKTHPRVATQDVRIGNQLVKAGDTVTCSLLAANR-PNYPSAEDEFDITR--- 360 Query: 442 KDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILT 501 +L FG G+ C+GR +AEL + + + F + D + L Sbjct: 361 -----EKAEHLAFGHGIHHCLGRAMAELMFKVSIPALAHRF----PTLRLADPQREITLG 411 Query: 502 P 502 P Sbjct: 412 P 412 >3NV6-A nrPDB Length = 452 Score = 109 bits (272), Expect = 3e-24, Method: Composition-based stats. Identities = 59/416 (14%), Positives = 124/416 (29%), Gaps = 63/416 (15%) Query: 100 YIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVM 159 + + V ++ + P A +Y P R L+ + Sbjct: 100 IATNGDTVKEVYSDPTRFSSEVIFLPKEAGEKYQMVPT---KMDPPEHTPYRKALDKGLN 156 Query: 160 APEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERL 219 + I + ++ S L +G F + E F ++ ++ + Sbjct: 157 LAK-----IRKVEDKVREVASSLIDSFAARGECDFAAEYAELFPVHVFMALADLPLED-- 209 Query: 220 GMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEK 279 +P+L+ T + + N Sbjct: 210 -------------------------IPVLSEYARQMTRPEGNTPEEMATDLEAGNNGFYA 244 Query: 280 YTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLY 339 Y + + ++ + E++ + + I+ +L GG++T L + + Sbjct: 245 YVDPIIRARVGGDGDDLITLMVNSEINGERIAHDKAQGLISLLLLGGLDTVVNFLSFFMI 304 Query: 340 EMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPES 399 +AR + LR + L R A +E R P+ + R Sbjct: 305 HLARHPELVAELRSDPLKLMRGA------------------EEMFRRFPVV-SEARMVAK 345 Query: 400 DLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVR 459 D + + ++ + G D A P K D +R + FG G Sbjct: 346 DQEYKGVFLKRGDMILLPTALHGLDDAANPEPWKLDFSR--------RSISHSTFGGGPH 397 Query: 460 QCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQ 515 +C G +A +E+ + L L+ G+ + I+ + + LV+ P + Sbjct: 398 RCAGMHLARMEVIVTLEEWLKRIPEFSFKEGETPIYHSGIVAAVENVPLVW-PIAR 452 >3DBM-A nrPDB Length = 473 Score = 108 bits (270), Expect = 5e-24, Method: Composition-based stats. Identities = 71/475 (14%), Positives = 154/475 (32%), Gaps = 63/475 (13%) Query: 43 KTPRPYSEIPSPGDNGWL-----NLYHFWREKGSQRIHFRHIENFQKYGPIYREKL---- 93 + +P EIP + L +F+ G ++ +Q ++R + Sbjct: 3 PSSKPLREIPGSYGIPFFQPIKDRLEYFYGTGGRDEYFRSRMQKYQS--TVFRANMPPGP 60 Query: 94 ---GNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKD 150 N + + ++ + LF + ++ + + + + Sbjct: 61 FVSSNPKVIVLLDAKSFPILFDVSKVEKKDLFTGTYMPSTKLTGGYRVLSYLDPSEPRHA 120 Query: 151 RVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESI 210 ++ M + IP + L + + G F ++ F F Sbjct: 121 QLKNLLFFMLKNSSNRVIPQFETTYTELFEGLEAELAKNGKAAFNDVGEQAAFRF----- 175 Query: 211 TNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSV-----PLLNV-PPELYRLFRTKTWR 264 LG NPE K + + + V P L++ P + T+R Sbjct: 176 --------LGRAYFNSNPEETKLGTSAPTLISSWVLFNLAPTLDLGLPWFLQEPLLHTFR 227 Query: 265 DHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLA 324 + +NK Y + + + E P + + ++ + Sbjct: 228 LPAFLIKSTYNKLYDYFQSVATPVMEQAEKLGVP---------KDEAVHNILFAVCFNTF 278 Query: 325 GGVNTT-SMTLQWHLYEMARSLNVQEMLREEVLNARRQ--AEGDISKMLQMVPLLKASIK 381 GGV TL+W N+ L EE+ A + + ++ +PL K+ + Sbjct: 279 GGVKILFPNTLKWIGLA---GENLHTQLAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVVY 335 Query: 382 ETLRLHPISVTLQRYPESDLVLQDYL----IPAKTLVQVAIYAMGRDPAFFSSPDKFDPT 437 E+LR+ P +S+ ++ + + ++ +DP F P+++ P Sbjct: 336 ESLRIEPPVPPQYGKAKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPD 395 Query: 438 RWLSKDKDLIHFRNLGFGWGV---------RQCVGRRIAELEMTLFLIHILENFK 483 R++ + L+ + + G +QC G+ L LF+I + + Sbjct: 396 RFVGDGEALLK--YVWWSNGPETESPTVENKQCAGKDFVVLITRLFVIELFRRYD 448 >5OMS-A nrPDB Length = 409 Score = 108 bits (270), Expect = 5e-24, Method: Composition-based stats. Identities = 49/383 (12%), Positives = 103/383 (26%), Gaps = 51/383 (13%) Query: 100 YIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVM 159 + E + ++ A R + P ++ R ++ + Sbjct: 44 VLGSYVASTAEVCREVATSPDFEAVITPAGGRTFGHP-AIIGVNGDIHADLRSMVEP-AL 101 Query: 160 APEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERL 219 P + ++ + + +R + G + V E ++ G+ L Sbjct: 102 QPAEVDR---WIDDLVRPIARRYLERFENDGHAELVAQY--------CEPVSVRSLGDLL 150 Query: 220 GMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEK 279 G+ E + + F + +V + A D + Sbjct: 151 GLQEVDSDKLREWFAKLNRSFTNAAVDENG----------EFANPEGFAEGDQAKAEIRA 200 Query: 280 YTEIFYQDLRRKTEFRNYPGILY-CLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHL 338 + + L+ + + E + I L G + + L Sbjct: 201 VVDPLIDKWIEHPDDSAISHWLHDGMPPGQTRDREYIYPTIYVYLLGAMQEPGHGMASTL 260 Query: 339 YEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISV-TLQRYP 397 + E + + L+ +I E LR R Sbjct: 261 VGLFSRPEQLEEV------------------VDDPTLIPRAIAEGLRWTSPIWSATARIS 302 Query: 398 ESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWG 457 + + +PA T V ++ + D + +P ++D R +L FG G Sbjct: 303 TKPVTIAGVDLPAGTPVMLSYGSANHDTGKYEAPSQYDLHRPPLP--------HLAFGAG 354 Query: 458 VRQCVGRRIAELEMTLFLIHILE 480 C G A M + L + E Sbjct: 355 NHACAGIYFANHVMRIALEELFE 377 >4C9K-A nrPDB Length = 421 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 62/420 (14%), Positives = 130/420 (30%), Gaps = 40/420 (9%) Query: 106 DVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVM-APEAI 164 + + ++ E+ W + P+ G W R L E+ +PE Sbjct: 24 LIREIDAYDLDGLEQGFHEAWKRVQQPDTPPLVWTPFTGGHWIATRGTLIDEIYRSPERF 83 Query: 165 KNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEE 224 + + + + + ++ ++ + I + L + + + + ++E Sbjct: 84 SSRVIWVPREAGEAYDMVPTKLDPPEHTPYRKAIDKGLNLAEIRKLEDQIRTIAVEIIEG 143 Query: 225 TVNPEAQKFIDAVYKMFHTSV--PLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAE---- 278 + +F +F V L +P E + +T + Sbjct: 144 FADRGHCEFGSEFSTVFPVRVFLALAGLPVEDATKLGLLANEMTRPSGNTPEEQGRSLEA 203 Query: 279 ------KYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSM 332 +Y R + IL + + M + ++ +L GG++T Sbjct: 204 ANKGFFEYVAPIIAARRGGSGTDLITRILNVEIDGKPMPDDRALGLVSLLLLGGLDTVVN 263 Query: 333 TLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVT 392 L + + ++R +R E L +R ++E R + + Sbjct: 264 FLGFMMIYLSRHPETVAEMRREPLKLQRG------------------VEELFRRFAVV-S 304 Query: 393 LQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNL 452 RY SD+ ++ L+ + G D P D +R + Sbjct: 305 DARYVVSDMEFHGTMLKEGDLILLPTALHGLDDRHHDDPMTVDLSR--------RDVTHS 356 Query: 453 GFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRP 512 F G +C G +A LE+T+ L L V + I+ + I L + P Sbjct: 357 TFAQGPHRCAGMHLARLEVTVMLQEWLARIPEFRLKDRAVPIYHSGIVAAVENIPLEWEP 416 >6FYJ-A nrPDB Length = 421 Score = 105 bits (261), Expect = 6e-23, Method: Composition-based stats. Identities = 67/424 (15%), Positives = 138/424 (32%), Gaps = 57/424 (13%) Query: 87 PIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGT 146 I+ +L +++ + E + E +R D P + K GV T Sbjct: 39 DIFETRLLGKKAICMGGKEAAEIFYDTEK--FKRKDAAPNRVVQTLFGKN-GVQALDGQT 95 Query: 147 WKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFA 206 K R + +M+P+ ++ L +++ + + +Q + KE + A Sbjct: 96 -HKHRKEMFMSIMSPDELEK----LTDITKKQWEIAVDKWEQMDKVILYEEAKEIMCRTA 150 Query: 207 FESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDH 266 + V E E ++ + MF ++ + + L R R++ Sbjct: 151 CQ-WAGVPVQEN----------EVKRLTKNLGAMFESA-AAVGLKHWLGR-----HARNY 193 Query: 267 VAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGG 326 W + ++ + +F Y + LL +E +E NI + Sbjct: 194 EEIWIEELIDRVRDGKVNPPENTTLHKFSWYRDLEGNLLDTETAAVE--VINILRPIVA- 250 Query: 327 VNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRL 386 ++ + + + +E L+ + ++E R Sbjct: 251 ---IAIFINFIALALHHYPEEKEKLKS-----------------GDKKYSQMFVQEVRRF 290 Query: 387 HPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDL 446 +P + + D + Y TL + +Y DP + +PD F P R+ + Sbjct: 291 YPFFPFVVALVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRFAKWEGSP 350 Query: 447 IHFRNLGFGWGV----RQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTP 502 F + G G +C G + M + L ++ E + D D F++ P Sbjct: 351 FSF--IPQGGGDYFMGHRCAGEWVTIEVMKVSLDYLTNRMDYE---VPDQDLSFSMASMP 405 Query: 503 DKPI 506 P Sbjct: 406 SIPH 409 >2IAG-A nrPDB Length = 482 Score = 103 bits (257), Expect = 2e-22, Method: Composition-based stats. Identities = 83/511 (16%), Positives = 173/511 (33%), Gaps = 78/511 (15%) Query: 43 KTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYII 102 +T RP G WL + + +K+G I+ +G ++ Sbjct: 1 RTRRPGEPPLDLGSIPWLG----YALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLL 56 Query: 103 HPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEV--MA 160 P YD W R + + + ++ + Sbjct: 57 DP--------------HSYDAVVWEPRTRLDFHAYAIFL--------MERIFDVQLPHYS 94 Query: 161 PEAIKNFIPL------LNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDL--FHFAFESITN 212 P K + L L +++ + LH + + G + L F ++F Sbjct: 95 PSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAG 154 Query: 213 VMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDT 272 + + L T +AQ + + +FHT L + P+L R + +DH+ + + Sbjct: 155 YLTLYGIEALPRTHESQAQDRVHS-ADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKS 213 Query: 273 IFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLED---VKANITEMLAGGVNT 329 R + LL E+M + + +A + ++ Sbjct: 214 RL-------WKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLW-ATQGN 265 Query: 330 TSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDIS-------KMLQMVPLLKASIKE 382 W L + ++ +R E+ + QAE +S K+L P+L + + E Sbjct: 266 MGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSE 325 Query: 383 TLRLHPISVTLQRYPESDLVL-----QDYLIPAKTLVQVAI-YAMGRDPAFFSSPDKFDP 436 +LRL + + R DL + +++ + + + + RDP ++ P+ F Sbjct: 326 SLRL-TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKY 384 Query: 437 TRWLSKDKDLIHFRN----------LGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEM 486 R+L+ D + +G G C+GR A + F+ +L + +E+ Sbjct: 385 NRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLEL 444 Query: 487 QHIG------DVDTIFNLILTPDKPIFLVFR 511 + D+ ++ P+ + + +R Sbjct: 445 INADVEIPEFDLSRYGFGLMQPEHDVPVRYR 475 >5M0P-A nrPDB Length = 428 Score = 95.7 bits (236), Expect = 4e-20, Method: Composition-based stats. Identities = 65/428 (15%), Positives = 133/428 (31%), Gaps = 72/428 (16%) Query: 88 IYREK-LGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGT 146 +++ K LG V + E + +R + P + K G + G Sbjct: 41 VFQTKALGGKPFVVVTGKEGAEMFY--NNDVVQREGMLPKRIVNTLAGK--GAIHTVDGK 96 Query: 147 WKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFA 206 DR L +M + + +++ +R++ +++ + Sbjct: 97 KHVDRKALFMSLMTEGNLN----YVRELTRTLWHANTQRMES----------MDEVNIYR 142 Query: 207 FESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDH 266 + G R ++ PE + I + S L + Y+ + R Sbjct: 143 ESIVLLTKVGTRWAGVQ--APPEDIERIATDMDIMIDSFRALGGAFKGYKASKEARRR-- 198 Query: 267 VAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKML--LEDVKANITEMLA 324 E + E + R+ LY E L D + +++ Sbjct: 199 ----------VEDWLEEQIIETRKGNIHPPEGTALYEFAHWEDYLGNPMDSRTCAIDLM- 247 Query: 325 GGVNTTSMTL------QWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKA 378 NT + + L+ M + +E ++ E Sbjct: 248 ---NTFRPLIAINRFVSFGLHAMNENPITREKIKSEPD------------------YAYK 286 Query: 379 SIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTR 438 +E R +P L + D+ Q IPA + + +Y D + + P++F P R Sbjct: 287 FAQEVRRYYPFVPFLPGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRPER 346 Query: 439 WLSKDKDLIHFRNLGFGWG----VRQCVGRRIAELEMTLFLIHILEN--FKVEMQHIG-D 491 + + D + G G +C G I + M + + E + V Q + D Sbjct: 347 FETWDGSPFDL--IPQGGGDYWTNHRCAGEWITVIIMEETMKYFAEKITYDVPEQDLEVD 404 Query: 492 VDTIFNLI 499 +++I + Sbjct: 405 LNSIPGYV 412 >5YHJ-A nrPDB Length = 413 Score = 95.3 bits (235), Expect = 6e-20, Method: Composition-based stats. Identities = 70/429 (16%), Positives = 132/429 (30%), Gaps = 75/429 (17%) Query: 88 IYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTW 147 I+ +L + + E + R D P + + GV Sbjct: 36 IFESRLLGERVICLGGEEAAEVFYDANK--FTRQDAAPKRLLKTLFGEG-GVQTLDGSEH 92 Query: 148 KKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDI-KEDLFHFA 206 R + +M E I + L +++ I++ G + DI +E L Sbjct: 93 TH-RKQMFMSLMTKENIDRLLRLT---YREWNQ-----IERMGEEIVLYDIAQEVLMKAV 143 Query: 207 FESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDH 266 E + E +G E + + Sbjct: 144 CEWSGVPLAKEEVGKRTEEMRLLFESGTSLGPTYLQG----------------------- 180 Query: 267 VAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLL----KSEKMLLEDVKANITEM 322 + AE + +++R N LY +S ++L E+V A Sbjct: 181 ----RKARSSAEVWIRQMVKEVRSNRLLPNEHTALYEFSWHRDESGELLPEEVVAVEVLN 236 Query: 323 LAGGVNTTSMTLQWHLYEMARSLNVQEML-REEVLNARRQAEGDISKMLQMVPLLKASIK 381 + S+ + + + + + +V+E + R EV ++ Sbjct: 237 ILRPTVAISVYVLFTVLALHQFPDVKEQVERGEVSKTE-------------------FVQ 277 Query: 382 ETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLS 441 E R +P ++D Y P TL + +Y D + ++ PD+FDP+R+ Sbjct: 278 EVRRFYPFFPVAAARVKTDFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSRF-- 335 Query: 442 KDKDLIHFRNLGFGWGV----RQCVGRRIAELEMTLFLIHILENFKVE-MQHIGDVDTIF 496 KD F + G G +C G + L ++E F E + D + Sbjct: 336 KDWKESPFNFIPQGGGDVDFGHRCAGEHVTIA----ILAQVIELFTKEYAYTVPPQDLSY 391 Query: 497 NLILTPDKP 505 + + P P Sbjct: 392 SFVDMPSLP 400 >3B98-A nrPDB Length = 475 Score = 94.1 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 63/391 (16%), Positives = 130/391 (33%), Gaps = 46/391 (11%) Query: 156 TEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMF 215 +V+ +P NP S+ + +H G + + + + +T Sbjct: 89 AQVLMKRIFNMILPSHNPESEKKRAEMHF------QGASLTQLSNSMQNNLRLLMTPSEM 142 Query: 216 GERLGM-LEETVNPEAQKFID-----AVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAA 269 G + ++ + + V+ + + L E +R F + Sbjct: 143 GLKTSEWKKDGLFNLCYSLLFKTGYLTVFGAENNNSAALTQIYEEFRRFDKLLPKLARTT 202 Query: 270 WD----TIFNKAEKYTEIFY--QDLRRKTEFRNYPGILYCLLKSEKMLLE-DVKANITEM 322 + I + A + + L RK +++ G L+ E + E +A + ++ Sbjct: 203 VNKEEKQIASAAREKLWKWLTPSGLDRKPREQSWLGSYVKQLQDEGIDAEMQRRAMLLQL 262 Query: 323 LAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKE 382 N W + + +REE+ + + K P+ + + E Sbjct: 263 WVTQGNAGPAAF-WVMGYLLTHPEALRAVREEIQGGKHLRLEERQK---NTPVFDSVLWE 318 Query: 383 TLRLHPISVTLQRYPESDLVL-----QDYLIPAKTLVQVAIY-AMGRDPAFFSSPDKFDP 436 TLRL + + R D + Q+Y + + V + + DP P+ F Sbjct: 319 TLRL-TAAALITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQF 377 Query: 437 TRWLS----------KDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEM 486 R+L+ K+ + + ++ +G C GR A + + IL F VE+ Sbjct: 378 DRFLNADRTEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVEL 437 Query: 487 Q------HIGDVDTIFNLILTPDKPIFLVFR 511 + D IL P + + +R Sbjct: 438 CDKNATVPLVDPSRYGFGILQPAGDLEIRYR 468 >2ZQJ-A nrPDB Length = 417 Score = 91.0 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 67/436 (15%), Positives = 137/436 (31%), Gaps = 74/436 (16%) Query: 87 PIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGT 146 +++ +L + + E + + +R + P + + + G+ Sbjct: 35 DLFQARLLGKNFICMTGAEAAKVFY--DTDRFQRQNALPKRVQKSLFG--VNAIQGMDGS 90 Query: 147 WKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFA 206 R +L +M P K L+ + V+ V LF A Sbjct: 91 AHIHRKMLFLSLMTPPHQKRLAELMTEEWKAAVTR-------WEKADEVV-----LFEEA 138 Query: 207 FESITNVM-FGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRD 265 E + V + + + E V A FID V + + + W+ Sbjct: 139 KEILCRVACYWAGVPLKETEVKERADDFIDMV---------------DAFGAVGPRHWKG 183 Query: 266 HVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLL---------KSEKMLLEDVK 316 A +AE++ E+ +D R L+ + +M ++ Sbjct: 184 RRARP-----RAEEWIEVMIEDARAGLLKTTSGTALHEMAFHTQEDGSQLDSRMAAIELI 238 Query: 317 ANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLL 376 + ++A S L + + +E LR R Sbjct: 239 NVLRPIVA-----ISYFLVFSALALHEHPKYKEWLRSGNSRER----------------- 276 Query: 377 KASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDP 436 + ++E R +P L + D V + T V + +Y DP + PD+F P Sbjct: 277 EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFRP 336 Query: 437 TRWLSKDKDLIHFRNLGFGWGV----RQCVGRRIAELEMTLFLIHILENFKVEMQHIGDV 492 R+ ++++L F + G G +C G I M L ++ + ++ Sbjct: 337 ERFAEREENL--FDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQSLH 394 Query: 493 DTIFNLILTPDKPIFL 508 ++ + P+ + Sbjct: 395 YSLARMPSLPESGFVM 410 >3AWQ-A nrPDB Length = 415 Score = 87.2 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 28/159 (17%), Positives = 56/159 (35%), Gaps = 6/159 (3%) Query: 355 VLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLV 414 V +A + G + ++Q + ++E R +P + D + P V Sbjct: 253 VAHALQTCSGIRAALVQQPDYAELFVQEVRRFYPFFPAVVARASQDFEWEGMAFPEGRQV 312 Query: 415 QVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGV----RQCVGRRIAELE 470 + +Y D A ++ P +F P R+ + D+D F + G G +C G I Sbjct: 313 VLDLYGSNHDAATWADPQEFRPERFRAWDED--SFNFIPQGGGDHYLGHRCPGEWIVLAI 370 Query: 471 MTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLV 509 M + ++ + ++ L P + Sbjct: 371 MKVAAHLLVNAMRYDVPDQDLSIDFARLPALPKSGFVMR 409 >2YJN-B nrPDB Length = 381 Score = 69.8 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 28/129 (21%), Positives = 52/129 (40%), Gaps = 18/129 (13%) Query: 323 LAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKE 382 L G T+ T+ + ++ + E + ++ A+R ++ E Sbjct: 220 LFAGAEMTANTVVDAVLAVSAEPGLAERIADDPAAAQR------------------TVAE 261 Query: 383 TLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSK 442 LRLHP +R +++ L +++I V V + A RDP F+ PD+ D R + Sbjct: 262 VLRLHPALHLERRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVDRPDAD 321 Query: 443 DKDLIHFRN 451 H + Sbjct: 322 RALSAHRGH 330 >4YXC-B nrPDB Length = 227 Score = 32.9 bits (73), Expect = 0.34, Method: Composition-based stats. Identities = 21/112 (18%), Positives = 44/112 (39%), Gaps = 12/112 (10%) Query: 313 EDVKANITEMLAGGVN----TTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISK 368 ++ + ++ A +N TT+ + +++ +V +++ K Sbjct: 99 DENTGALDDLWADALNEQKATTTKSAADAVFQQLGGGDVSGAMQD-----IDLIMDIPVK 153 Query: 369 MLQMVPLLKASIKETLRL-HPISVTLQRYPES--DLVLQDYLIPAKTLVQVA 417 + + + +IKE LRL V L D+++ YLI +V VA Sbjct: 154 LTVELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVVA 205 >4YXB-D nrPDB Length = 80 Score = 31.3 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 15/45 (33%), Positives = 21/45 (46%), Gaps = 3/45 (6%) Query: 376 LKASIKETLRL-HPISVTLQRYPES--DLVLQDYLIPAKTLVQVA 417 + +IKE LRL V L D+++ YLI +V VA Sbjct: 14 TRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVVA 58 >2WKX-A nrPDB Length = 261 Score = 30.9 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 26/95 (27%), Gaps = 1/95 (1%) Query: 111 FKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPL 170 E I W R IG+ + G W+K V P I+ IPL Sbjct: 75 LVPEQELAWHAGISAWRGATRLNDTSIGIELENRG-WQKSAGVKYFAPFEPAQIQALIPL 133 Query: 171 LNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHF 205 + + + D LF + Sbjct: 134 AKDIIARYHIKPENVVAHADIAPQRKDDPGPLFPW 168 >3RFT-A nrPDB Length = 267 Score = 30.2 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 7/51 (13%), Positives = 16/51 (31%), Gaps = 10/51 (19%) Query: 419 YAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAEL 469 + ++ ++ P D +GV +C G +A + Sbjct: 109 ASSNHTIGYYPQTERLGPDVPARPDGL----------YGVSKCFGENLARM 149 >1ZC1-A nrPDB Length = 208 Score = 29.8 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 6/30 (20%), Positives = 13/30 (43%) Query: 376 LKASIKETLRLHPISVTLQRYPESDLVLQD 405 + + +E R +PI++ R + D Sbjct: 17 MPQTFEEFFRCYPIAMMNDRIRKDDANFGG 46 >1EF9-A nrPDB Length = 261 Score = 29.4 bits (64), Expect = 3.9, Method: Composition-based stats. Identities = 32/228 (14%), Positives = 60/228 (26%), Gaps = 19/228 (8%) Query: 185 RIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTS 244 R S F+ D+ + L I ++ G + + + Sbjct: 23 RKLNALSKVFIDDLMQALSDLNRPEIRCIILRAPSGSKVFSAGHDIHELPSGGRDPLSYD 82 Query: 245 VPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCL 304 PL + + + + + W F I + G+ Y L Sbjct: 83 DPLRQITRMIQKFPKPIISMVEGSVWGGAFEMIMSSDLIIAASTSTFSMTPVNLGVPYNL 142 Query: 305 LKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEG 364 + + + + E++ T+ + LN EV Sbjct: 143 VGIHNLTRDAGFHIVKELIF-----TASPITAQRALAVGILNHVV----EVEELEDFTLQ 193 Query: 365 DISKMLQMVPLLKASIKETLRLHPISVTL----------QRYPESDLV 402 + + PL A IKE LR+ + T+ R D Sbjct: 194 MAHHISEKAPLAIAVIKEELRVLGEAHTMNSDEFERIQGMRRAVYDSE 241 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.122 0.314 Lambda K H 0.267 0.0376 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,773,035 Number of Sequences: 36641 Number of extensions: 779091 Number of successful extensions: 2904 Number of sequences better than 10.0: 178 Number of HSP's better than 10.0 without gapping: 282 Number of HSP's successfully gapped in prelim test: 56 Number of HSP's that attempted gapping in prelim test: 2025 Number of HSP's gapped (non-prelim): 364 length of query: 520 length of database: 10,336,785 effective HSP length: 101 effective length of query: 419 effective length of database: 6,636,044 effective search space: 2780502436 effective search space used: 2780502436 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (28.2 bits)