BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= O95970 (557 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5Y31-B nrPDB 1082 0.0 2V9T-B nrPDB 85 1e-16 1XCD-A nrPDB 65 9e-11 3J0A-A nrPDB 64 1e-10 5ZSN-B nrPDB 64 2e-10 5LFN-A nrPDB 64 2e-10 2FT3-A nrPDB 57 3e-08 2XOT-A nrPDB 56 5e-08 3ULU-A nrPDB 55 1e-07 5GY2-A nrPDB 52 6e-07 4R6F-A nrPDB 52 7e-07 2Z7X-B nrPDB 50 3e-06 2Z80-A nrPDB 49 5e-06 3A7C-A nrPDB 49 5e-06 5D3I-A nrPDB 49 7e-06 2Z7X-A nrPDB 48 1e-05 6GFF-I nrPDB 47 2e-05 5MX0-A nrPDB 47 3e-05 3T6Q-A nrPDB 46 4e-05 3A79-B nrPDB 46 4e-05 4AY9-X nrPDB 45 8e-05 6O00-A nrPDB 45 1e-04 1XWD-C nrPDB 45 1e-04 3CIG-A nrPDB 44 2e-04 4PBW-B nrPDB 44 2e-04 2IFG-A nrPDB 42 6e-04 3V44-A nrPDB 41 0.001 3RG1-A nrPDB 40 0.002 3B2D-A nrPDB 40 0.003 4PBV-A nrPDB 39 0.004 5YQ5-A nrPDB 39 0.006 5Y3K-A nrPDB 38 0.014 4R08-A nrPDB 37 0.015 5XJX-C nrPDB 37 0.018 4QDH-A nrPDB 35 0.062 4PUF-A nrPDB 35 0.070 5Y3M-A nrPDB 35 0.096 5JNF-C nrPDB 34 0.16 5ES8-A nrPDB 34 0.17 5ES6-A nrPDB 34 0.20 3WPI-A nrPDB 33 0.33 1JL5-A nrPDB 31 1.4 5Y6P-24 nrPDB 31 1.6 6ICZ-o nrPDB 30 3.2 1M9S-A nrPDB 29 4.8 6IOL-A nrPDB 29 6.7 3JB9-j nrPDB 28 7.0 4FGR-A nrPDB 28 8.4 >5Y31-B nrPDB Length = 544 Score = 1082 bits (2798), Expect = 0.0, Method: Compositional matrix adjust. Identities = 520/521 (99%), Positives = 520/521 (99%) Query: 37 PAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLL 96 PAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLL Sbjct: 17 PAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLL 76 Query: 97 LFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPK 156 LFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPK Sbjct: 77 LFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPK 136 Query: 157 DIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSS 216 DIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSS Sbjct: 137 DIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSS 196 Query: 217 KDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYD 276 KDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYD Sbjct: 197 KDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYD 256 Query: 277 NITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIE 336 NITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIE Sbjct: 257 NITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIE 316 Query: 337 TFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRT 396 TFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRT Sbjct: 317 TFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRT 376 Query: 397 PHLILSSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSK 456 PHLILSSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSK Sbjct: 377 PHLILSSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSK 436 Query: 457 VMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQE 516 VMKWGGSSFQDIQ MPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQE Sbjct: 437 VMKWGGSSFQDIQAMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQE 496 Query: 517 LNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA 557 LNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA Sbjct: 497 LNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA 537 >2V9T-B nrPDB Length = 220 Score = 84.7 bits (208), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 87/207 (42%), Gaps = 28/207 (13%) Query: 42 CPAVCTCTKDNALCENA--RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFT 99 CPA CTC+ + C IP +P + + ++ I G+F L+ + + Sbjct: 5 CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLS 64 Query: 100 SNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRG---------------------- 137 +N ++ DAF GL L L + N I + + F G Sbjct: 65 NNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAF 124 Query: 138 --LKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNA-T 194 L +L LSL +N LQT+ K F L ++ + L N F CDC LKWL ++L HTN Sbjct: 125 QDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYL-HTNPIE 183 Query: 195 VEDIYCEGPPEYKKRKINSLSSKDFDC 221 C P ++I + SK F C Sbjct: 184 TSGARCTSPRRLANKRIGQIKSKKFRC 210 >1XCD-A nrPDB Length = 329 Score = 64.7 bits (156), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 41/142 (28%), Positives = 64/142 (45%), Gaps = 5/142 (3%) Query: 36 KPAKPKCPAVCTCTKDNALCENA--RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSL 93 +P P CP C C C + +P+ +PPD L + TEI +G F +L Sbjct: 19 EPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNL 78 Query: 94 QLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQT 153 L+ +N IS AF L LE L++ N +K + + K+L L + N + Sbjct: 79 HTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPE---KMPKTLQELRVHENEITK 135 Query: 154 LPKDIFKGLDSLTNVDLRGNSF 175 + K +F GL+ + V+L N Sbjct: 136 VRKSVFNGLNQMIVVELGTNPL 157 Score = 35.4 bits (80), Expect = 0.068, Method: Compositional matrix adjust. Identities = 18/71 (25%), Positives = 32/71 (45%) Query: 57 NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPH 116 N +IP+ +PP + L + T++ S +L L + NS + + + PH Sbjct: 182 NITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH 241 Query: 117 LEYLFIENNNI 127 L L + NN + Sbjct: 242 LRELHLNNNKL 252 Score = 31.2 bits (69), Expect = 1.4, Method: Compositional matrix adjust. Identities = 23/87 (26%), Positives = 36/87 (41%) Query: 72 LSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSIS 131 LS++R T I+ PSL L N + + GL +L L + N+I ++ Sbjct: 173 LSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVD 232 Query: 132 RHTFRGLKSLIHLSLANNNLQTLPKDI 158 + L L L NN L +P + Sbjct: 233 NGSLANTPHLRELHLNNNKLVKVPGGL 259 >3J0A-A nrPDB Length = 844 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 48/158 (30%), Positives = 72/158 (45%), Gaps = 28/158 (17%) Query: 91 PSLQLLLFTSNSFDVISD-----DAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLS 145 PSL+ L N + + D F GL HL+ L++ +N + S+ F L +L LS Sbjct: 451 PSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLS 510 Query: 146 LANNNLQTLP-KDIFKGLD------------------SLTNVDLRGNSFNCDCKLKWLVE 186 L +N L L D+ L+ SL+ +D+ N F C+C+L + Sbjct: 511 LNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFIN 570 Query: 187 WLGHTNATV----EDIYCEGPPEYKKRKINSLSSKDFD 220 WL HTN T+ DIYC P + + SLS++ D Sbjct: 571 WLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCD 608 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 32/120 (26%), Positives = 54/120 (45%), Gaps = 11/120 (9%) Query: 93 LQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQ 152 L++L N + I+D+AF GL +L+ L + N + + F GL + ++ L N++ Sbjct: 292 LKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIA 351 Query: 153 TLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKIN 212 + FK L+ L +DLR N+ H ++ DI+ G KIN Sbjct: 352 IIQDQTFKFLEKLQTLDLRDNALTTI-----------HFIPSIPDIFLSGNKLVTLPKIN 400 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 25/87 (28%), Positives = 45/87 (51%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI 127 D+ L+ + +I++ +F +LQ+L + N + F GLP + Y+ ++ N+I Sbjct: 291 DLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHI 350 Query: 128 KSISRHTFRGLKSLIHLSLANNNLQTL 154 I TF+ L+ L L L +N L T+ Sbjct: 351 AIIQDQTFKFLEKLQTLDLRDNALTTI 377 Score = 29.3 bits (64), Expect = 4.9, Method: Compositional matrix adjust. Identities = 23/70 (32%), Positives = 33/70 (47%), Gaps = 2/70 (2%) Query: 106 ISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQ--TLPKDIFKGLD 163 I +AF LP+L L + ++ I + F+GL L L L L L F+ L Sbjct: 64 IDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLK 123 Query: 164 SLTNVDLRGN 173 +LT +DL N Sbjct: 124 ALTRLDLSKN 133 >5ZSN-B nrPDB Length = 823 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 41/156 (26%), Positives = 76/156 (48%), Gaps = 6/156 (3%) Query: 65 VPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIEN 124 +PP++ +LS ++G + +L+ L + N + + L+ L ++N Sbjct: 651 MPPNLKNLSLAKNGLKSFIWEKLRYLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKN 710 Query: 125 NNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKG--LDSLTNVDLRGNSFNCDCKLK 182 N I+S++++ + L +L L++N +Q + K F L++L + L N F C C Sbjct: 711 NQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAV 770 Query: 183 WLVEWLGHTNATV----EDIYCEGPPEYKKRKINSL 214 W V W+ HT T+ D+ C GP +K + + SL Sbjct: 771 WFVWWVQHTEVTIPYLATDVTCVGPGAHKGQSVISL 806 Score = 35.8 bits (81), Expect = 0.051, Method: Compositional matrix adjust. Identities = 35/124 (28%), Positives = 53/124 (42%), Gaps = 11/124 (8%) Query: 50 KDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDD 109 KDN N ++P +P + L + EI E F LQ+L + N + Sbjct: 190 KDN----NVTTVPTVLPSTLTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNC-PRCYNA 244 Query: 110 AFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVD 169 F P +NN+ I + F L L L L +N+LQ +P FK +++L +D Sbjct: 245 PFPCTP------CKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELD 298 Query: 170 LRGN 173 L N Sbjct: 299 LSQN 302 Score = 35.4 bits (80), Expect = 0.065, Method: Compositional matrix adjust. Identities = 23/72 (31%), Positives = 37/72 (51%), Gaps = 3/72 (4%) Query: 106 ISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSL 165 I DAF+ L L+ L +++NN+ ++ +L L L NN + + +D F L+ L Sbjct: 173 IEKDAFLNLTKLKVLSLKDNNVTTVPTVL---PSTLTELYLYNNMIAEIQEDDFNNLNQL 229 Query: 166 TNVDLRGNSFNC 177 +DL GN C Sbjct: 230 QILDLSGNCPRC 241 >5LFN-A nrPDB Length = 337 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 39/117 (33%), Positives = 59/117 (50%), Gaps = 4/117 (3%) Query: 96 LLFTSNSFDVISDDAFIGLP-HLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL 154 L + N I D+AF +LE L+++N N++ S F G+ +L H+ L NN L L Sbjct: 202 LKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAFLGVTTLKHVHLENNRLNQL 261 Query: 155 PKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKI 211 P + DSL + L N + C C+L+ L WL A+ D C P ++K + I Sbjct: 262 PSNF--PFDSLETLALTNNPWKCTCQLRGLRRWL-EAKASRPDATCASPAKFKGQHI 315 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 42/155 (27%), Positives = 70/155 (45%), Gaps = 13/155 (8%) Query: 42 CPAVCTCTKD--NALCENA--RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLL 97 CP C C D + +C+ + IP+ V L+ R+ F ++ SF P+L L Sbjct: 1 CPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLH 59 Query: 98 FTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD 157 ++ AF GL L YL++ +N+I+ + F L L +L L +N + LP+ Sbjct: 60 LQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRG 119 Query: 158 IFKGLDSLTNV--------DLRGNSFNCDCKLKWL 184 + L +L + +LR +F L+WL Sbjct: 120 LLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWL 154 Score = 48.1 bits (113), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 30/109 (27%), Positives = 50/109 (45%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNN 126 P+++SL E++ G+F L L + N V+ AF L L YL++++N Sbjct: 53 PNLVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNK 112 Query: 127 IKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSF 175 + + R L +L L L NN ++ L F+G L + L N+ Sbjct: 113 VTELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENAL 161 >2FT3-A nrPDB Length = 332 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 34/136 (25%), Positives = 64/136 (47%), Gaps = 5/136 (3%) Query: 42 CPAVCTCTKDNALCENA--RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFT 99 CP C C C + +++P+ + PD L + +E+ + F L L+ Sbjct: 27 CPFGCHCHLRVVQCSDLGLKAVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLV 86 Query: 100 SNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIF 159 +N I + AF L L+ L+I N++ I + SL+ L + +N ++ +PK +F Sbjct: 87 NNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNL---PSSLVELRIHDNRIRKVPKGVF 143 Query: 160 KGLDSLTNVDLRGNSF 175 GL ++ +++ GN Sbjct: 144 SGLRNMNCIEMGGNPL 159 >2XOT-A nrPDB Length = 361 Score = 55.8 bits (133), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 34/135 (25%), Positives = 69/135 (51%), Gaps = 3/135 (2%) Query: 42 CPAVCTCTKDNALCENAR--SIPRTVPPDVISLSFVRSGFTEI-SEGSFLFTPSLQLLLF 98 CPA C C + C + ++P+++P L + + + +E + +L LL Sbjct: 12 CPANCLCASNILSCSKQQLPNVPQSLPSYTALLDLSHNNLSRLRAEWTPTRLTNLHSLLL 71 Query: 99 TSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDI 158 + N + IS +AF+ +P+L YL + +N++ ++ F L++L L L NN++ + ++ Sbjct: 72 SHNHLNFISSEAFVPVPNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNA 131 Query: 159 FKGLDSLTNVDLRGN 173 F+ + L + L N Sbjct: 132 FEDMAQLQKLYLSQN 146 >3ULU-A nrPDB Length = 694 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 37/124 (29%), Positives = 54/124 (43%), Gaps = 30/124 (24%) Query: 113 GLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIF------KGLD--- 163 GL HL L +E+N I F+ L L + L NNL TLP +F K L+ Sbjct: 544 GLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQK 603 Query: 164 ----------------SLTNVDLRGNSFNCDCK-LKWLVEWLGHTNATVEDI----YCEG 202 +LT +D+R N F+C C+ + W V W+ T+ + ++ C Sbjct: 604 NLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNT 663 Query: 203 PPEY 206 PP Y Sbjct: 664 PPHY 667 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 61/234 (26%), Positives = 95/234 (40%), Gaps = 52/234 (22%) Query: 71 SLSFVRSGFTEISEGSFLFTP--SLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIK 128 +LS S + S +FL +L +L + N+ +V+ +D+F LP LEY F+E NNI+ Sbjct: 236 NLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQ 295 Query: 129 SISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWL 188 + H+ GL ++ +L+L ++ K L SL +D D +WL + L Sbjct: 296 HLFSHSLHGLFNVRYLNLK----RSFTKQSI-SLASLPKID--------DFSFQWL-KCL 341 Query: 189 GHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDL-----------PYQSL 237 H N DI P K L + + + F + L P L Sbjct: 342 EHLNMEDNDI-----PGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHIL 396 Query: 238 SI----------DTFSYLNDEYVV------IAQPFTGKCIFLEWDHVEKTFRNY 275 ++ D FS+L V+ I Q TG+ EW +E F Y Sbjct: 397 NLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQ----EWRGLENIFEIY 446 Score = 33.9 bits (76), Expect = 0.17, Method: Compositional matrix adjust. Identities = 26/80 (32%), Positives = 41/80 (51%), Gaps = 1/80 (1%) Query: 93 LQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI-KSISRHTFRGLKSLIHLSLANNNL 151 L +L T N I DAF L HLE L + N I + ++ +RGL+++ + L+ N Sbjct: 393 LHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKY 452 Query: 152 QTLPKDIFKGLDSLTNVDLR 171 L ++ F + SL + LR Sbjct: 453 LQLTRNSFALVPSLQRLMLR 472 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 20/63 (31%), Positives = 33/63 (52%) Query: 91 PSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNN 150 P L++L N +SD F +L L + +N+I+ I + F K+LI L L++N Sbjct: 83 PMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNG 142 Query: 151 LQT 153 L + Sbjct: 143 LSS 145 >5GY2-A nrPDB Length = 455 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 36/121 (29%), Positives = 56/121 (46%), Gaps = 25/121 (20%) Query: 93 LQLLLFTSNSFDVISDDAFIGLPH------------------------LEYLFIENNNIK 128 L+ L N + I D+AF GL H LE L + N+I+ Sbjct: 301 LEQLTLAQNEINKIDDNAFWGLTHLLKLNLSQNFLGSIDSRMFENLDKLEVLDLSYNHIR 360 Query: 129 SISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDC-KLKWLVEW 187 ++ +F GL +L L+L N L+++P IF L SL + L N ++C C ++ +L W Sbjct: 361 ALGDQSFLGLPNLKELALDTNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLSRW 420 Query: 188 L 188 L Sbjct: 421 L 421 Score = 33.9 bits (76), Expect = 0.19, Method: Compositional matrix adjust. Identities = 33/96 (34%), Positives = 45/96 (46%), Gaps = 11/96 (11%) Query: 101 NSFDVISDDAFIGLPHLEYLFIENNNIKSISRH-TFRGLKSLIHLSLANNNLQTLPKDIF 159 NS +++ +F L L++L +E + R+ TFRGL SLI L L N L F Sbjct: 40 NSIAELNETSFSRLQDLQFLKVEQQTPGLVIRNNTFRGLSSLIILKLDYNQFLQLETGAF 99 Query: 160 KGLDSL-------TNVD---LRGNSFNCDCKLKWLV 185 GL +L N+D L GN F L+ LV Sbjct: 100 NGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLV 135 >4R6F-A nrPDB Length = 331 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 34/116 (29%), Positives = 60/116 (51%), Gaps = 8/116 (6%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI 127 ++ +L+ +GF EI F SL L ++N+ I+D GL +L L + +NN+ Sbjct: 190 NLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNL 249 Query: 128 KSISRHT--------FRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSF 175 + +H +GL +L L+L++N +P+++FK L SLT ++L N Sbjct: 250 ARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNQL 305 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 56/207 (27%), Positives = 95/207 (45%), Gaps = 26/207 (12%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI 127 ++ +L+ + T + +G F SL L ++N+ I+D GL +L L + +NN+ Sbjct: 110 NLTTLNLSNNQLTSLPQGVFERLASLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNL 169 Query: 128 KSISRHT--------FRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFN--C 177 + +H +GL +L L+L++N +P+++FK L SLT ++L N+ Sbjct: 170 ARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNNIANIN 229 Query: 178 DCKLKWLVEW----LGHTN-ATVEDIYCEGPPEYKKRKIN-----SLSSKDFDCIITEFA 227 D L+ L L H N A + G P Y + + +LSS FD I E Sbjct: 230 DQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVF 289 Query: 228 KSQDLPYQSLSIDTFSYLNDEYVVIAQ 254 K DL S+ T + N++ + Q Sbjct: 290 K--DLT----SLTTLNLSNNQLTSLPQ 310 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 51/175 (29%), Positives = 84/175 (48%), Gaps = 15/175 (8%) Query: 89 FTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLAN 148 + P+++ L N IS A L +L +L + NN ++++ + F L +L L+L+N Sbjct: 61 YLPNVRYLALGGNKLHDIS--ALKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSN 118 Query: 149 NNLQTLPKDIFKGLDSLTNVDLRGNSFN--CDCKLKWLVEW----LGHTN-ATVEDIYCE 201 N L +LP+ +F+ L SLT ++L N+ D L+ L L H N A + Sbjct: 119 NQLTSLPQGVFERLASLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANP 178 Query: 202 GPPEYKKRKIN-----SLSSKDFDCIITE-FAKSQDLPYQSLSIDTFSYLNDEYV 250 G P Y + + +LSS FD I E F L +LS + + +ND+ + Sbjct: 179 GGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNNIANINDQML 233 Score = 41.6 bits (96), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 33/112 (29%), Positives = 51/112 (45%), Gaps = 8/112 (7%) Query: 72 LSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSIS 131 L+ + + +G F +L L ++N + F L L L + NNNI +I+ Sbjct: 90 LNLSNNQLETLPQGVFEKLTNLTTLNLSNNQLTSLPQGVFERLASLTTLNLSNNNIANIN 149 Query: 132 RHTFRGLKSLIHLSLANNNLQTL--------PKDIFKGLDSLTNVDLRGNSF 175 GL +L L+L++NNL L P KGL +LT ++L N F Sbjct: 150 DQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGF 201 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 26/76 (34%), Positives = 44/76 (57%), Gaps = 2/76 (2%) Query: 100 SNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIF 159 +N+ D+ S LP++ YL + N + IS + L +L L+L+NN L+TLP+ +F Sbjct: 48 ANNSDIKSVQGIQYLPNVRYLALGGNKLHDIS--ALKELTNLGWLNLSNNQLETLPQGVF 105 Query: 160 KGLDSLTNVDLRGNSF 175 + L +LT ++L N Sbjct: 106 EKLTNLTTLNLSNNQL 121 Score = 35.8 bits (81), Expect = 0.056, Method: Compositional matrix adjust. Identities = 23/62 (37%), Positives = 34/62 (54%) Query: 92 SLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNL 151 +L L +SN FD I + F L L L + NN + S+ + F L +L L+L+NN L Sbjct: 270 NLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNQLTSLPQGVFERLTNLKTLNLSNNQL 329 Query: 152 QT 153 Q+ Sbjct: 330 QS 331 >2Z7X-B nrPDB Length = 520 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 36/108 (33%), Positives = 62/108 (57%), Gaps = 6/108 (5%) Query: 84 EGSFLFTPSLQLLLFTSNSFDVISDDAFIGLP-HLEYLFIENNNIKSISRHTFRGLKSLI 142 +G +T SL L +SN +++D F LP ++ L + +N IKSI + + L++L Sbjct: 392 KGDCSWTKSLLSLNMSSN---ILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVK-LEALQ 447 Query: 143 HLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDC-KLKWLVEWLG 189 L++A+N L+++P IF L SL + L N ++C C ++ +L WL Sbjct: 448 ELNVASNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLSRWLN 495 >2Z80-A nrPDB Length = 353 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 37/115 (32%), Positives = 57/115 (49%), Gaps = 5/115 (4%) Query: 44 AVCTCTKDNALCENA----RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFT 99 A +C + N +C+ + SIP + V SL + T IS +LQ L+ T Sbjct: 26 ASLSCDR-NGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLT 84 Query: 100 SNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL 154 SN + I +D+F L LE+L + N + ++S F+ L SL L+L N +TL Sbjct: 85 SNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTL 139 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 39/121 (32%), Positives = 59/121 (48%), Gaps = 5/121 (4%) Query: 60 SIPRTVPPDVISLSFVRSGFTEISEGSFLFTPS-----LQLLLFTSNSFDVISDDAFIGL 114 S+ + + SLS R+G + S GS PS ++ L ++N IS+ Sbjct: 16 SLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRC 75 Query: 115 PHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNS 174 +L+ L + +N I +I +F L SL HL L+ N L L FK L SLT ++L GN Sbjct: 76 VNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNP 135 Query: 175 F 175 + Sbjct: 136 Y 136 >3A7C-A nrPDB Length = 580 Score = 49.3 bits (116), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 33/95 (34%), Positives = 49/95 (51%) Query: 60 SIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEY 119 SIP + + SL + T I G +LQ+L+ S+ + I DAF L LE+ Sbjct: 45 SIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEH 104 Query: 120 LFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL 154 L + +N++ S+S F L SL +L+L N QTL Sbjct: 105 LDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTL 139 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 29/98 (29%), Positives = 55/98 (56%), Gaps = 7/98 (7%) Query: 92 SLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNL 151 +L++L ++N+ D S + LP L+ L+I N +K++ + L+ + +A+N L Sbjct: 458 TLEVLDVSNNNLDSFS----LFLPRLQELYISRNKLKTLPDASL--FPVLLVMKIASNQL 511 Query: 152 QTLPKDIFKGLDSLTNVDLRGNSFNCDC-KLKWLVEWL 188 +++P IF L SL + L N ++C C ++ +L WL Sbjct: 512 KSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLSRWL 549 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 29/98 (29%), Positives = 47/98 (47%), Gaps = 3/98 (3%) Query: 78 GFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRG 137 FT I G T +++ L + N I +L+ L ++++ I +I F Sbjct: 42 SFTSIPSG---LTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYS 98 Query: 138 LKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSF 175 L SL HL L++N+L +L F L SL ++L GN + Sbjct: 99 LGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPY 136 >5D3I-A nrPDB Length = 568 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 33/95 (34%), Positives = 49/95 (51%) Query: 60 SIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEY 119 SIP + + SL + T I G +LQ+L+ S+ + I DAF L LE+ Sbjct: 23 SIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEH 82 Query: 120 LFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL 154 L + +N++ S+S F L SL +L+L N QTL Sbjct: 83 LDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTL 117 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 29/98 (29%), Positives = 47/98 (47%), Gaps = 3/98 (3%) Query: 78 GFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRG 137 FT I G T +++ L + N I +L+ L ++++ I +I F Sbjct: 20 SFTSIPSG---LTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYS 76 Query: 138 LKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSF 175 L SL HL L++N+L +L F L SL ++L GN + Sbjct: 77 LGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPY 114 Score = 36.6 bits (83), Expect = 0.029, Method: Compositional matrix adjust. Identities = 30/141 (21%), Positives = 57/141 (40%), Gaps = 24/141 (17%) Query: 92 SLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNL 151 +L++L ++N+ D S + LP L+ L+I N +K++ + L+ + + N + Sbjct: 436 TLEVLDVSNNNLDSFS----LFLPRLQELYISRNKLKTLPDASL--FPVLLVMKIRENAV 489 Query: 152 QTLPKDIFKGLDSLTNVDLRGNSFNCDCKL-----------KWLVEWLGHTNATVEDIYC 200 T KD L ++ N F C C+L + LV+W + C Sbjct: 490 STFSKDQLGSFPKLETLEAGDNHFVCSCELLSFTMETPALAQILVDW-------PDSYLC 542 Query: 201 EGPPEYKKRKINSLSSKDFDC 221 + PP ++ +C Sbjct: 543 DSPPRLHGHRLQDARPSVLEC 563 >2Z7X-A nrPDB Length = 549 Score = 48.1 bits (113), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 35/107 (32%), Positives = 53/107 (49%), Gaps = 4/107 (3%) Query: 52 NALCENA----RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVIS 107 N +C+ + SIP + V SL + T IS +LQ L+ TSN + I Sbjct: 7 NGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIE 66 Query: 108 DDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL 154 +D+F L LE+L + N + ++S F+ L SL L+L N +TL Sbjct: 67 EDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTL 113 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 38/110 (34%), Positives = 55/110 (50%), Gaps = 5/110 (4%) Query: 71 SLSFVRSGFTEISEGSFLFTPS-----LQLLLFTSNSFDVISDDAFIGLPHLEYLFIENN 125 SLS R+G + S GS PS ++ L ++N IS+ +L+ L + +N Sbjct: 1 SLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSN 60 Query: 126 NIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSF 175 I +I +F L SL HL L+ N L L FK L SLT ++L GN + Sbjct: 61 GINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPY 110 >6GFF-I nrPDB Length = 618 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 31/99 (31%), Positives = 49/99 (49%), Gaps = 1/99 (1%) Query: 80 TEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIG-LPHLEYLFIENNNIKSISRHTFRGL 138 T +S G P + L + NS + +G P L L + N++ ++RHTFR + Sbjct: 94 TALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDM 153 Query: 139 KSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNC 177 +L L L +N L + F+GL LT+++L NS C Sbjct: 154 PALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTC 192 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/114 (29%), Positives = 56/114 (49%), Gaps = 12/114 (10%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNN 126 P + +LS + T ++ +F P+L+ L SN I D AF GLP L +L + N+ Sbjct: 130 PSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNS 189 Query: 127 IKSISRHTFRGLKSLIHLSLANNNLQTL-----PKDIFKGLDSLTNVDLRGNSF 175 + IS + + L+ L L+ N+++ P+ F+ LT +DLR N Sbjct: 190 LTCISDFSLQQLRV---LDLSCNSIEAFQTASQPQAEFQ----LTWLDLRENKL 236 Score = 35.8 bits (81), Expect = 0.044, Method: Compositional matrix adjust. Identities = 46/156 (29%), Positives = 64/156 (41%), Gaps = 28/156 (17%) Query: 71 SLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGL-PHLEYLFIENNNIK- 128 SLS V + + G+FL TP +L L +SN ++ A GL LE L ++ N + Sbjct: 428 SLSLVDNEIELLRAGAFLHTPLTELDL-SSNPGLEVATGALGGLEASLEVLALQGNGLMV 486 Query: 129 -SISRHTFRGLK-------------------SLIHLSLANNNLQTLPKDIFKGLD-SLTN 167 + F LK SL L L NN+ LP GL+ SL Sbjct: 487 LQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRR 546 Query: 168 VDLRGNSFNCDCKLKWLVEWLGHTNATV---EDIYC 200 + L+GN +C C WL L V +D+ C Sbjct: 547 LYLQGNPLSC-CGNGWLAAQLHQGRVDVDATQDLIC 581 Score = 28.1 bits (61), Expect = 9.6, Method: Compositional matrix adjust. Identities = 31/120 (25%), Positives = 48/120 (40%), Gaps = 15/120 (12%) Query: 92 SLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRH---------TFRGLKSLI 142 SL+ LL N+ + F L L+ L ++ N + F G+ SL Sbjct: 368 SLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLR 427 Query: 143 HLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEG 202 LSL +N ++ L F LT +DL N L+ LG A++E + +G Sbjct: 428 SLSLVDNEIELLRAGAFLH-TPLTELDLSSNP-----GLEVATGALGGLEASLEVLALQG 481 >5MX0-A nrPDB Length = 362 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 40/145 (27%), Positives = 66/145 (45%), Gaps = 12/145 (8%) Query: 37 PAKPK-CPAVCTCTKD---NALCENA--RSIPRTVPPDVISLSFVRSGFTEISEGSFLFT 90 P P+ CP C C + C+N + +P VP + + F + T I EG F Sbjct: 56 PPDPRDCPQECDCPPNFPTAMYCDNRNLKYLP-FVPSRMKYVYFQNNQITSIQEGVFDNA 114 Query: 91 PSLQLLLFTSNSF--DVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLAN 148 L + N D + F L HLE L++++NN+ + R L+ L L + Sbjct: 115 TGLLWIALHGNQITSDKVGRKVFSKLRHLERLYLDHNNLTRMPGPLPRSLRE---LHLDH 171 Query: 149 NNLQTLPKDIFKGLDSLTNVDLRGN 173 N + +P + +GL++LT + L+ N Sbjct: 172 NQISRVPNNALEGLENLTALYLQHN 196 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 36/131 (27%), Positives = 61/131 (46%), Gaps = 25/131 (19%) Query: 92 SLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNL 151 SL+ L N + ++A GL +L L++++N I+ + + RGL+SLI L L+ N+L Sbjct: 163 SLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQEVGS-SMRGLRSLILLDLSYNHL 221 Query: 152 QTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNA-TVEDIYCEGPPE--YKK 208 + +P + L+ L ++ H N TV D Y G P+ Y + Sbjct: 222 RKVPDGLPSALEQL---------------------YMEHNNVYTVPDSYFRGAPKLLYVR 260 Query: 209 RKINSLSSKDF 219 NSL++ Sbjct: 261 LSHNSLTNNGL 271 >3T6Q-A nrPDB Length = 606 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 30/126 (23%), Positives = 59/126 (46%), Gaps = 4/126 (3%) Query: 93 LQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQ 152 L++L+ + I AF L + ++ + +N + S S LK I+L+LA+N++ Sbjct: 478 LEILVLSFCDLSSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKG-IYLNLASNHIS 536 Query: 153 TLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATV---EDIYCEGPPEYKKR 209 + + L ++LR N +C C + +EW + ED CE PP + Sbjct: 537 IILPSLLPILSQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLEDTEDTLCENPPLLRGV 596 Query: 210 KINSLS 215 +++ ++ Sbjct: 597 RLSDVT 602 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 69/274 (25%), Positives = 120/274 (43%), Gaps = 22/274 (8%) Query: 60 SIPRTVPPDVISLSFV---RSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPH 116 +I T +I+L+F+ R I E +F L L+ T+N +++ A G Sbjct: 47 TIQNTTFSRLINLTFLDLTRCQIYWIHEDTFQSQHRLDTLVLTANPLIFMAETALSGPKA 106 Query: 117 LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQT--LPKDIFKGLDSLTNVDLRGNS 174 L++LF I SI K+L L L +N++ + LPK + L +D + N+ Sbjct: 107 LKHLFFIQTGISSIDFIPLHNQKTLESLYLGSNHISSIKLPKGF--PTEKLKVLDFQNNA 164 Query: 175 FNCDCKLKWLVEWLGHTNATV----EDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQ 230 + K + + TN ++ DI P + SL+ ++ F + Sbjct: 165 IHYLSK-EDMSSLQQATNLSLNLNGNDIAGIEPGAFDSAVFQSLNFGGTQNLLVIFKGLK 223 Query: 231 DLPYQSLSIDTFSYLNDEYVVIAQPFTGKC-IFLEWDHVEKTFRNYDNITGTSTVVCKPI 289 + QSL + TF ++DE + A F G C + +E +++K + + NI+ ++T C Sbjct: 224 NSTIQSLWLGTFEDMDDEDISPA-VFEGLCEMSVESINLQKHY--FFNIS-SNTFHCFSG 279 Query: 290 VIE-----TQLYVIVAQLFGGSHIYKRDSFANKF 318 + E T L + + L G S + K ANKF Sbjct: 280 LQELDLTATHLSELPSGLVGLSTLKKLVLSANKF 313 Score = 29.3 bits (64), Expect = 4.6, Method: Compositional matrix adjust. Identities = 25/84 (29%), Positives = 44/84 (52%), Gaps = 1/84 (1%) Query: 93 LQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIK-SISRHTFRGLKSLIHLSLANNNL 151 LQ L + N + +AF P LE L + +K ++ F+ L L L+L+++ L Sbjct: 378 LQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKDAQSPFQNLHLLKVLNLSHSLL 437 Query: 152 QTLPKDIFKGLDSLTNVDLRGNSF 175 + +F GL +L +++L+GN F Sbjct: 438 DISSEQLFDGLPALQHLNLQGNHF 461 >3A79-B nrPDB Length = 562 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 28/95 (29%), Positives = 51/95 (53%), Gaps = 2/95 (2%) Query: 115 PHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNS 174 P ++ L + NN I SI + L++L L++A+N L+++P +F L SL + L N Sbjct: 450 PKVKVLDLHNNRIMSIPKDV-THLQALQELNVASNQLKSVPDGVFDRLTSLQYIWLHDNP 508 Query: 175 FNCDCK-LKWLVEWLGHTNATVEDIYCEGPPEYKK 208 ++C C +++L EW+ + V + P+ K Sbjct: 509 WDCTCPGIRYLSEWINKHSGVVRNSAGSVAPDSAK 543 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 32/119 (26%), Positives = 56/119 (47%), Gaps = 5/119 (4%) Query: 56 ENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLP 115 N +P+ +PP +LS ++ +E+ F L++L + N + F+ Sbjct: 41 RNLTHVPKDLPPRTKALSLSQNSISELRMPDISFLSELRVLRLSHNRIRSLDFHVFLFNQ 100 Query: 116 HLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNS 174 LEYL + +N +++IS + SL HL L+ N+ LP + K +LT + G S Sbjct: 101 DLEYLDVSHNRLQNIS---CCPMASLRHLDLSFNDFDVLP--VCKEFGNLTKLTFLGLS 154 >4AY9-X nrPDB Length = 350 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 38/147 (25%), Positives = 67/147 (45%), Gaps = 29/147 (19%) Query: 45 VCTCTKDNALCENAR--SIPRTVPPDVISLSFVRSGFTEISEGSF--------------- 87 +C C+ LC+ ++ IP +P + I L FV + I +G+F Sbjct: 6 ICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQND 65 Query: 88 --------LFT--PSL-QLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISR-HTF 135 +F+ P L ++ + +N+ I+ +AF LP+L+YL I N IK + H Sbjct: 66 VLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKI 125 Query: 136 RGLKSLIHLSLANNNLQTLPKDIFKGL 162 L+ ++ N N+ T+ ++ F GL Sbjct: 126 HSLQKVLLDIQDNINIHTIERNSFVGL 152 >6O00-A nrPDB Length = 820 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 40/125 (32%), Positives = 63/125 (50%), Gaps = 18/125 (14%) Query: 93 LQLLLFTSNSFDVISDDAFIGL-PHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNL 151 L+ L + N+ + D IGL +L+ L + N I+++ F+ + L L L NN L Sbjct: 687 LRYLDLSHNNLTFLPAD--IGLLQNLQNLAVTANRIEALPPELFQC-RKLRALHLGNNVL 743 Query: 152 QTLPKDIFKGLDSLTNVDLRGNSFNC------DCKLKWLVEWLGHTNATV-EDIYCEGPP 204 Q+LP + + L +LT ++LRGN C +C L L + V ED++ PP Sbjct: 744 QSLPSRVGE-LTNLTQIELRGNRLECLPVELGECPL------LKRSGLVVEEDLFSTLPP 796 Query: 205 EYKKR 209 E K+R Sbjct: 797 EVKER 801 >1XWD-C nrPDB Length = 252 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 38/147 (25%), Positives = 67/147 (45%), Gaps = 29/147 (19%) Query: 45 VCTCTKDNALCENAR--SIPRTVPPDVISLSFVRSGFTEISEGSF--------------- 87 +C C+ LC+ ++ IP +P + I L FV + I +G+F Sbjct: 6 ICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQND 65 Query: 88 --------LFT--PSL-QLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISR-HTF 135 +F+ P L ++ + +N+ I+ +AF LP+L+YL I N IK + H Sbjct: 66 VLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKI 125 Query: 136 RGLKSLIHLSLANNNLQTLPKDIFKGL 162 L+ ++ N N+ T+ ++ F GL Sbjct: 126 HSLQKVLLDIQDNINIHTIERNSFVGL 152 >3CIG-A nrPDB Length = 697 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 32/124 (25%), Positives = 53/124 (42%), Gaps = 30/124 (24%) Query: 113 GLPHLEYLFIENNNIKSISRHTFRGL------------------------KSLIHLSLAN 148 GL HL L +E+N + I F+ L SL L+L Sbjct: 534 GLSHLHILNLESNGLDEIPVGVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQK 593 Query: 149 NNLQTLPKDIF-KGLDSLTNVDLRGNSFNCDCK-LKWLVEWLGHTNATVEDI----YCEG 202 N + ++ KD+F +L ++D+R N F+C C+ + W V W+ T+ + ++ C Sbjct: 594 NLITSVEKDVFGPPFQNLNSLDMRFNPFDCTCESISWFVNWINQTHTNISELSTHYLCNT 653 Query: 203 PPEY 206 P Y Sbjct: 654 PHHY 657 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 10/108 (9%) Query: 79 FTEISEGSFLFTPSLQLLLFTSNSFDV--ISDDAFIGLPHLEYLFIENNNIKSISRHTFR 136 + ++S SF PSLQ L+ + IS F L +L L + NNNI +I+ Sbjct: 442 YLQLSTSSFALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDLLE 501 Query: 137 GLKSLIHLSLANNNLQTL--------PKDIFKGLDSLTNVDLRGNSFN 176 GL++L L +NNL L P + KGL L ++L N + Sbjct: 502 GLENLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLESNGLD 549 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 32/112 (28%), Positives = 57/112 (50%), Gaps = 9/112 (8%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI 127 ++ L + ++ GSF + PSL+ L N+ +S +F GL +L YL ++ Sbjct: 249 NLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSLKRAFT 308 Query: 128 K---SISRH------TFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDL 170 K S++ H +F+ LK L +L++ +NN+ + + F GL SL + L Sbjct: 309 KQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSL 360 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 27/59 (45%), Positives = 37/59 (62%), Gaps = 2/59 (3%) Query: 106 ISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLAN--NNLQTLPKDIFKGL 162 I D +F L +LEYL +++NNI S +TF GL SL +LSL+ +LQTL + F L Sbjct: 320 IDDFSFQWLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSLSKTFTSLQTLTNETFVSL 378 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 24/77 (31%), Positives = 45/77 (58%), Gaps = 2/77 (2%) Query: 101 NSFDVISDDAFIGLPHLEYLFIENNNIKS--ISRHTFRGLKSLIHLSLANNNLQTLPKDI 158 N + +S +F +P L+ L + +K+ IS FR L++L L L+NNN+ + +D+ Sbjct: 440 NKYLQLSTSSFALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDL 499 Query: 159 FKGLDSLTNVDLRGNSF 175 +GL++L +D + N+ Sbjct: 500 LEGLENLEILDFQHNNL 516 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 32/132 (24%), Positives = 58/132 (43%), Gaps = 2/132 (1%) Query: 46 CTCTKDNALCENAR--SIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSF 103 CT + A C + + IP +P ++ L+ + + +F L +L NS Sbjct: 2 CTVRYNVADCSHLKLTHIPDDLPSNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSI 61 Query: 104 DVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLD 163 + + LP L+ L +++N + IS TF +L L L +N++ + + FK Sbjct: 62 SKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQK 121 Query: 164 SLTNVDLRGNSF 175 +L +DL N Sbjct: 122 NLIKLDLSHNGL 133 Score = 37.4 bits (85), Expect = 0.017, Method: Compositional matrix adjust. Identities = 27/80 (33%), Positives = 43/80 (53%), Gaps = 2/80 (2%) Query: 69 VISLSFVRSGFTEISEGSF--LFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNN 126 + +LS + SE +F L +L L + N+ + + +F LP L YL +E NN Sbjct: 224 IQNLSLANNQLLATSESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNN 283 Query: 127 IKSISRHTFRGLKSLIHLSL 146 I+ +S +F GL +L +LSL Sbjct: 284 IQRLSPRSFYGLSNLRYLSL 303 Score = 35.8 bits (81), Expect = 0.049, Method: Compositional matrix adjust. Identities = 29/98 (29%), Positives = 48/98 (48%), Gaps = 7/98 (7%) Query: 63 RTVPPDVIS----LSFVRSGFTEISEGS---FLFTPSLQLLLFTSNSFDVISDDAFIGLP 115 R +PP + L+ + +GF IS+ P L++L N ISD F+ Sbjct: 38 RRLPPTNFTRYSQLAILDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCT 97 Query: 116 HLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQT 153 +L L + +N+I I + F+ K+LI L L++N L + Sbjct: 98 NLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSS 135 Score = 35.4 bits (80), Expect = 0.068, Method: Compositional matrix adjust. Identities = 28/82 (34%), Positives = 41/82 (50%), Gaps = 2/82 (2%) Query: 92 SLQLLLFTSNSFDVISDDAFIGLP--HLEYLFIENNNIKSISRHTFRGLKSLIHLSLANN 149 S+Q L +N S+ F GL +L L + NN+ + +F L SL +LSL N Sbjct: 223 SIQNLSLANNQLLATSESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYN 282 Query: 150 NLQTLPKDIFKGLDSLTNVDLR 171 N+Q L F GL +L + L+ Sbjct: 283 NIQRLSPRSFYGLSNLRYLSLK 304 >4PBW-B nrPDB Length = 283 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 42/174 (24%), Positives = 73/174 (41%), Gaps = 31/174 (17%) Query: 42 CPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSN 101 CPA C C+K + C+ PD +L + G GS S+Q+ + N Sbjct: 4 CPANCLCSKTDINCK---------KPDDGNLFPLLEGQ---DSGSSNGQTSIQITDISRN 51 Query: 102 -------------SFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLAN 148 + + + + + G L+ L I N+ +++I F L ++ L+ Sbjct: 52 ITSIHIENWKNLQTLNAVDMELYTG---LQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSG 108 Query: 149 NNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWL--GHTNATVEDIYC 200 N L TL +F+ L L ++ L N F C C ++W+ W G N + ++C Sbjct: 109 NRLTTLSWQLFQTL-RLFDLRLERNPFQCSCDIRWIQLWQEKGEANLQSQQLHC 161 >2IFG-A nrPDB Length = 347 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 30/95 (31%), Positives = 44/95 (46%), Gaps = 9/95 (9%) Query: 113 GLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRG 172 GL L L I + ++ ++ F L L+L+ N L++L +GL SL + L G Sbjct: 54 GLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGL-SLQELVLSG 112 Query: 173 NSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYK 207 N +C C L+WL W E+ G PE K Sbjct: 113 NPLHCSCALRWLQRW--------EEEGLGGVPEQK 139 >3V44-A nrPDB Length = 407 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 28/97 (28%), Positives = 42/97 (43%), Gaps = 25/97 (25%) Query: 93 LQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQ 152 L+ L N + I D+AF GL HL+ L ++ N +KS+ Sbjct: 301 LEQLTLAQNEINKIDDNAFWGLTHLKELALDTNQLKSV---------------------- 338 Query: 153 TLPKDIFKGLDSLTNVDLRGNSFNCDC-KLKWLVEWL 188 P IF L SL + L N ++C C ++ +L WL Sbjct: 339 --PDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLSRWL 373 Score = 34.3 bits (77), Expect = 0.14, Method: Compositional matrix adjust. Identities = 33/96 (34%), Positives = 45/96 (46%), Gaps = 11/96 (11%) Query: 101 NSFDVISDDAFIGLPHLEYLFIENNNIKSISRH-TFRGLKSLIHLSLANNNLQTLPKDIF 159 NS +++ +F L L++L +E + R+ TFRGL SLI L L N L F Sbjct: 40 NSIAELNETSFSRLQDLQFLKVEQQTPGLVIRNNTFRGLSSLIILKLDYNQFLQLETGAF 99 Query: 160 KGLDSL-------TNVD---LRGNSFNCDCKLKWLV 185 GL +L N+D L GN F L+ LV Sbjct: 100 NGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLV 135 >3RG1-A nrPDB Length = 612 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 28/121 (23%), Positives = 48/121 (39%), Gaps = 26/121 (21%) Query: 117 LEYLFIENNNIKSISRHTFRGLKSLIHLSL-----------------------ANNNLQT 153 LE L + + N+ SI + F GL+++ HL L A+NN++ Sbjct: 477 LEILILSSCNLLSIDQQAFHGLRNVNHLDLSHNSLTGDSMDALSHLKGLYLNMASNNIRI 536 Query: 154 LPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLG---HTNATVEDIYCEGPPEYKKRK 210 +P + L + ++L N +C C + W H E+ C PP + K Sbjct: 537 IPPHLLPALSQQSIINLSHNPLDCTCSNIHFITWYKENLHKLEDSEETTCANPPSLRGVK 596 Query: 211 I 211 + Sbjct: 597 L 597 Score = 32.7 bits (73), Expect = 0.44, Method: Compositional matrix adjust. Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 1/84 (1%) Query: 93 LQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHT-FRGLKSLIHLSLANNNL 151 LQ L + N + D AF P LE L + ++ + H+ F+ L L L+L++ L Sbjct: 377 LQYLNLSYNEPLGLEDQAFKECPQLELLDVAFTHLHVKAPHSPFQNLHLLRVLNLSHCLL 436 Query: 152 QTLPKDIFKGLDSLTNVDLRGNSF 175 T + + GL L +++L+GNSF Sbjct: 437 DTSNQHLLAGLQDLRHLNLQGNSF 460 Score = 30.8 bits (68), Expect = 1.8, Method: Compositional matrix adjust. Identities = 34/127 (26%), Positives = 59/127 (46%), Gaps = 10/127 (7%) Query: 103 FDVISDDAFIGLPHLEYLFIENNNIK--SISR-HTFRGLKSLIHLSLANNNLQTLPKDIF 159 D + GL L +L ++ N+ + SIS+ + + + SL L L++ NL ++ + F Sbjct: 436 LDTSNQHLLAGLQDLRHLNLQGNSFQDGSISKTNLLQMVGSLEILILSSCNLLSIDQQAF 495 Query: 160 KGLDSLTNVDLRGNSFNCD-----CKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSL 214 GL ++ ++DL NS D LK L +L + + I P ++ I +L Sbjct: 496 HGLRNVNHLDLSHNSLTGDSMDALSHLKGL--YLNMASNNIRIIPPHLLPALSQQSIINL 553 Query: 215 SSKDFDC 221 S DC Sbjct: 554 SHNPLDC 560 Score = 29.6 bits (65), Expect = 3.3, Method: Compositional matrix adjust. Identities = 26/105 (24%), Positives = 50/105 (47%), Gaps = 13/105 (12%) Query: 98 FTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD 157 TS +F+ + D + +E + ++ + +S TFR + L L +L LP Sbjct: 242 LTSATFEGLCDMS------VESINLQKHRFSDLSSSTFRCFTRVQELDLTAAHLNGLPSG 295 Query: 158 IFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEG 202 I +G++SL + L NSF+ C++ + ++ D+Y +G Sbjct: 296 I-EGMNSLKKLVLNANSFDQLCQIN------AASFPSLRDLYIKG 333 Score = 28.9 bits (63), Expect = 6.9, Method: Compositional matrix adjust. Identities = 34/127 (26%), Positives = 52/127 (40%), Gaps = 27/127 (21%) Query: 55 CENA--RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQ-----------LLLFTSN 101 CEN R IP T+P TE+ E SF F P++Q L T Sbjct: 18 CENLGLREIPDTLP-----------NTTEVLEFSFNFLPTIQNTTFSRLINLIFLDLTRC 66 Query: 102 SFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLAN---NNLQTLPKDI 158 + + +D F L + + N + ++ + G K L HL L +NL+ +P Sbjct: 67 QINWVHEDTFQSHHQLNTIVLTGNPLIFMAETSLTGPKFLKHLFLTQTGISNLEFIPVHN 126 Query: 159 FKGLDSL 165 + L+SL Sbjct: 127 LENLESL 133 >3B2D-A nrPDB Length = 603 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 32/124 (25%), Positives = 57/124 (45%), Gaps = 6/124 (4%) Query: 92 SLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNL 151 SL++L+ +S I AF L + ++ + +N++ S + LK I+L+LA N++ Sbjct: 474 SLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKG-IYLNLAANSI 532 Query: 152 QTLPKDIFKGLDSLTNVDLRGNSFNCDCK----LKWLVEWLGHTNATVEDIYCEGPPEYK 207 + + L + ++L N +C C L W E L H E+ C PP + Sbjct: 533 NIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENL-HKLEGSEETTCANPPSLR 591 Query: 208 KRKI 211 K+ Sbjct: 592 GVKL 595 Score = 32.7 bits (73), Expect = 0.47, Method: Compositional matrix adjust. Identities = 26/89 (29%), Positives = 47/89 (52%), Gaps = 3/89 (3%) Query: 93 LQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIK--SISR-HTFRGLKSLIHLSLANN 149 LQ+L T D + GLP L +L ++ N+ + +I++ + + + SL L L++ Sbjct: 424 LQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSC 483 Query: 150 NLQTLPKDIFKGLDSLTNVDLRGNSFNCD 178 L ++ + F L +++VDL NS CD Sbjct: 484 GLLSIDQQAFHSLGKMSHVDLSHNSLTCD 512 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 33/116 (28%), Positives = 49/116 (42%), Gaps = 5/116 (4%) Query: 55 CENA--RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFI 112 CEN IP T+P L F + I +F +L L T + I +D F Sbjct: 16 CENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQ 75 Query: 113 GLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLAN---NNLQTLPKDIFKGLDSL 165 L L + N + ++ + G KSL HL L +NL+ +P + L+SL Sbjct: 76 SHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESL 131 >4PBV-A nrPDB Length = 268 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 34/168 (20%), Positives = 61/168 (36%), Gaps = 34/168 (20%) Query: 42 CPAVCTCTKDNALC---ENARSIPRTVPPDVISLSFVR----SGFTEISEGSFLFTPSLQ 94 CPA C C+K + C ++ P D +++ + ++ LQ Sbjct: 4 CPANCLCSKTDINCKKPDDGNLFPLLEGQDSRNITSIHIENWKNLQTLNAVDMELYTGLQ 63 Query: 95 LLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL 154 L ++ I AF PHL Y+ + N + ++S F+ L+ Sbjct: 64 RLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLSWQLFQTLR--------------- 108 Query: 155 PKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWL--GHTNATVEDIYC 200 L ++ L N F C C ++W+ W G N + ++C Sbjct: 109 ----------LFDLRLERNPFQCSCDIRWIQLWQEKGEANLQSQQLHC 146 >5YQ5-A nrPDB Length = 430 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 24/75 (32%), Positives = 40/75 (53%), Gaps = 2/75 (2%) Query: 93 LQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKS--ISRHTFRGLKSLIHLSLANNN 150 +Q L N + ++ ++FI HL+ + + +N IKS I F L +L+ L L +NN Sbjct: 91 IQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHLEHNN 150 Query: 151 LQTLPKDIFKGLDSL 165 L+ P + K L+ L Sbjct: 151 LEEFPFPLPKSLERL 165 Score = 36.6 bits (83), Expect = 0.029, Method: Compositional matrix adjust. Identities = 22/48 (45%), Positives = 29/48 (60%), Gaps = 1/48 (2%) Query: 113 GLPH-LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIF 159 GLP L YL +ENN+I SI F L L L +++N LQ +P +IF Sbjct: 228 GLPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIPYNIF 275 Score = 35.8 bits (81), Expect = 0.057, Method: Compositional matrix adjust. Identities = 29/102 (28%), Positives = 47/102 (46%), Gaps = 6/102 (5%) Query: 54 LCENA-RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFI 112 LC N S+P +P ++ LS + + I E F P L L + N I + F Sbjct: 217 LCSNRLESMPPGLPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIPYNIF- 275 Query: 113 GLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL 154 LP++ L + +N +K F ++L HL L NN ++ + Sbjct: 276 NLPNIVELSVGHNKLKQ----AFYIPRNLEHLYLQNNEIEKM 313 Score = 35.0 bits (79), Expect = 0.090, Method: Compositional matrix adjust. Identities = 36/136 (26%), Positives = 60/136 (44%), Gaps = 11/136 (8%) Query: 42 CPAVCTCTKD---NALCENAR--SIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLL 96 C + C C + + C+N + +IP +P + L + ++ SF+ L+ + Sbjct: 60 CVSECFCPTNFPSSMYCDNRKLKTIP-NIPMHIQQLYLQFNEIEAVTANSFINATHLKEI 118 Query: 97 LFTSNSFDVISDD--AFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL 154 + N D F LP+L L +E+NN++ F KSL L L N + L Sbjct: 119 NLSHNKIKSQKIDYGVFAKLPNLLQLHLEHNNLEEFP---FPLPKSLERLLLGYNEISKL 175 Query: 155 PKDIFKGLDSLTNVDL 170 + GL +LT +DL Sbjct: 176 QTNAMDGLVNLTMLDL 191 >5Y3K-A nrPDB Length = 802 Score = 37.7 bits (86), Expect = 0.014, Method: Compositional matrix adjust. Identities = 35/143 (24%), Positives = 65/143 (45%), Gaps = 12/143 (8%) Query: 44 AVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSF 103 AV T + N ++P +P ++SL R+ ++ S +L+ L N + Sbjct: 100 AVPTLEELNLSYNGITTVP-ALPSSLVSLILSRTNILQLDPTSLTGLHALRFLYMDGNCY 158 Query: 104 --------DVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLP 155 ++ A +GL +L +L ++ NN+ ++ R SL +L L+ N++ TL Sbjct: 159 YKNPCGRALEVAPGALLGLGNLTHLSLKYNNLTTVPRSL---PPSLEYLLLSYNHIVTLA 215 Query: 156 KDIFKGLDSLTNVDLRGNSFNCD 178 + L +L +D+ GN CD Sbjct: 216 PEDLANLTALRVLDVGGNCRRCD 238 Score = 35.4 bits (80), Expect = 0.066, Method: Compositional matrix adjust. Identities = 33/131 (25%), Positives = 55/131 (41%), Gaps = 6/131 (4%) Query: 86 SFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLS 145 S P+L+ L N +S+ + L+ L + N+I + F L L+ Sbjct: 651 SLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLDVSRNSIIFVVPGFFALATRLRELN 710 Query: 146 LANNNLQTLPKDIFKGL-DSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVED----IYC 200 L+ N L+T+ F L SL +D+ N +C C + V++L A V + C Sbjct: 711 LSANALRTVEPSWFGFLAGSLEVLDVSANPLHCACGAAF-VDFLLQVQAAVPGLPSRVKC 769 Query: 201 EGPPEYKKRKI 211 P + + R I Sbjct: 770 GSPGQLQGRSI 780 Score = 29.6 bits (65), Expect = 3.8, Method: Compositional matrix adjust. Identities = 33/138 (23%), Positives = 58/138 (42%), Gaps = 21/138 (15%) Query: 57 NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSN--------------- 101 N ++PR++PP + L + ++ +L++L N Sbjct: 189 NLTTVPRSLPPSLEYLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCVECP 248 Query: 102 -SFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQ--TLPKDI 158 F + D F L LE L ++++++ ++ FRGL +L L L+ N L Sbjct: 249 HKFPQLHSDTFSHLSRLEGLVLKDSSLYQLNPRWFRGLGNLTVLDLSENFLYDCITKTKA 308 Query: 159 FKGLDSLTNVDLRGNSFN 176 F+GL L ++L SFN Sbjct: 309 FQGLAQLRRLNL---SFN 323 >4R08-A nrPDB Length = 811 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 35/142 (24%), Positives = 55/142 (38%), Gaps = 30/142 (21%) Query: 115 PHLEYL------------------------FIENNNIKSISRHTFRGLKSLIHLSLANNN 150 P LE L + +N I + + SL HL L++N Sbjct: 666 PRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNL 725 Query: 151 LQTLPKDIF--KGLDSLTNVDLRGNSFNCDCKL----KWLVEWLGHTNATVEDIYCEGPP 204 L+T+ K K L+ ++L GN F C C + +W+ E L + D+ C P Sbjct: 726 LKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPG 785 Query: 205 EYKKRKINSLSSKDFDCIITEF 226 + + + I SL +TEF Sbjct: 786 DQRGKSIVSLELTTCVSDVTEF 807 Score = 33.9 bits (76), Expect = 0.21, Method: Compositional matrix adjust. Identities = 44/147 (29%), Positives = 64/147 (43%), Gaps = 24/147 (16%) Query: 53 ALCENAR--SIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFT----------- 99 A C N R +P+TV V L + T I+ SF +L + Sbjct: 25 AECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGN 84 Query: 100 ----SNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGL-KSLIHLSLANNNLQTL 154 SN + I+D AF+ L +L L +E+N + I GL +SL LSL NN+ + Sbjct: 85 PGIQSNGLN-ITDGAFLNLKNLRELLLEDNQLPQIP----SGLPESLTELSLIQNNIYNI 139 Query: 155 PKDIFKGLDSLTNVDLRGNS-FNCDCK 180 K+ L +L N+ L N FN C+ Sbjct: 140 TKEGISRLINLKNLYLAWNCYFNKVCE 166 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 39/145 (26%), Positives = 57/145 (39%), Gaps = 38/145 (26%) Query: 67 PDVISLSFVRSGFTEISEGS-FLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL----- 120 PD+ L+ + ++ G+ F P ++ L T+N D + A L LE L Sbjct: 483 PDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYN 542 Query: 121 --------------FIEN-----------NNIKSISRHTFRGLKSLIHLSLANNNLQTLP 155 FI+N NNI +++ KSL+ L + N L L Sbjct: 543 SHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILW 602 Query: 156 KD-------IFKGLDSLTNVDLRGN 173 D IFKGL +LT +DL N Sbjct: 603 NDDDNRYISIFKGLKNLTRLDLSLN 627 Score = 28.1 bits (61), Expect = 9.5, Method: Compositional matrix adjust. Identities = 16/38 (42%), Positives = 24/38 (63%) Query: 140 SLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNC 177 SL L L+N ++ + ++ FKGL +LT +DL GN C Sbjct: 201 SLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRC 238 >5XJX-C nrPDB Length = 433 Score = 37.4 bits (85), Expect = 0.018, Method: Compositional matrix adjust. Identities = 25/74 (33%), Positives = 45/74 (60%), Gaps = 4/74 (5%) Query: 113 GLPHLEYLFIENNN--IKSISRHTFRGLKSLIHLSLANNNLQ-TLPKDIFKGLDSLTNVD 169 GL L+ L ++ N +I + F+GLK+L+ L L+N N+Q ++PK + + L+SL + Sbjct: 272 GLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTR-LNSLRVLH 330 Query: 170 LRGNSFNCDCKLKW 183 L GN+ + L++ Sbjct: 331 LEGNNLTGEIPLEF 344 >4QDH-A nrPDB Length = 438 Score = 35.4 bits (80), Expect = 0.062, Method: Compositional matrix adjust. Identities = 32/129 (24%), Positives = 57/129 (44%), Gaps = 26/129 (20%) Query: 86 SFLFTPSLQLLLFTSNSFDVISDD-----------------------AFIGLP-HLEYLF 121 S F P+L++L N +++ AF L L+ + Sbjct: 259 SLSFLPNLEVLDLAGNQLKALTNGTLPNGTLLQKLDVSSNSIVSVVPAFFALAVELKEVN 318 Query: 122 IENNNIKSISRHTFRGL-KSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDC- 179 + +N +K++ R F + +L L+L N L+++P IF L SL + L N ++C C Sbjct: 319 LSHNILKTVDRSWFGPIVMNLKELALDTNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCP 378 Query: 180 KLKWLVEWL 188 ++ +L WL Sbjct: 379 RIDYLSRWL 387 Score = 33.9 bits (76), Expect = 0.20, Method: Compositional matrix adjust. Identities = 33/143 (23%), Positives = 51/143 (35%), Gaps = 27/143 (18%) Query: 37 PAKPKCPAVCTCTKDNALC--ENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQ 94 P CP+ C+C+ C + S+P +P L Sbjct: 3 PGGKACPSRCSCSGTEIRCNSKGLTSVPTGIPSSATRLEL-------------------- 42 Query: 95 LLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNL-QT 153 SN + F L L L + NN+ +I F L L LSL++N++ Q Sbjct: 43 ----ESNKLQSLPHGVFDKLTQLTKLSLSRNNLVTIKPEMFVNLSRLQCLSLSHNSIAQA 98 Query: 154 LPKDIFKGLDSLTNVDLRGNSFN 176 + F L +L +DL N + Sbjct: 99 VNGSQFLPLTNLQVLDLSHNKLD 121 >4PUF-A nrPDB Length = 637 Score = 35.4 bits (80), Expect = 0.070, Method: Compositional matrix adjust. Identities = 29/107 (27%), Positives = 52/107 (48%), Gaps = 11/107 (10%) Query: 60 SIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPH-LE 118 SIP T+P + + + TE+ E +LQ L N + ++ LP L Sbjct: 106 SIPATLPDTIQEMELSINRITELPER---LPSALQSLDLFHNKISCLPEN----LPEELR 158 Query: 119 YLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSL 165 YL + +N+I+++ H + HL++ +N+L LP+ + GL +L Sbjct: 159 YLSVYDNSIRTLPAHLP---SEITHLNVQSNSLTALPETLPPGLKTL 202 >5Y3M-A nrPDB Length = 801 Score = 35.0 bits (79), Expect = 0.096, Method: Compositional matrix adjust. Identities = 21/73 (28%), Positives = 39/73 (53%), Gaps = 3/73 (4%) Query: 106 ISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSL 165 ++ A +GL +L +L ++ NN+ + R L +L+ L+ N++ TL + L +L Sbjct: 169 VAPGALLGLGNLTHLSLKYNNLTEVPRRLPPSLDTLL---LSYNHIVTLAPEDLANLTAL 225 Query: 166 TNVDLRGNSFNCD 178 +D+ GN CD Sbjct: 226 RVLDVGGNCRRCD 238 Score = 33.9 bits (76), Expect = 0.21, Method: Compositional matrix adjust. Identities = 21/69 (30%), Positives = 33/69 (47%), Gaps = 8/69 (11%) Query: 105 VISDDAFIGLPHLEYLFIENN--------NIKSISRHTFRGLKSLIHLSLANNNLQTLPK 156 V+ F GL L +L+++ N ++ GL +L HLSL NNL +P+ Sbjct: 136 VLGPTHFTGLHALRFLYMDGNCYYMNPCPRALEVAPGALLGLGNLTHLSLKYNNLTEVPR 195 Query: 157 DIFKGLDSL 165 + LD+L Sbjct: 196 RLPPSLDTL 204 Score = 29.6 bits (65), Expect = 3.5, Method: Compositional matrix adjust. Identities = 32/122 (26%), Positives = 47/122 (38%), Gaps = 19/122 (15%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENN-- 125 ++ LS + TE+ PSL LL + N ++ + L L L + N Sbjct: 179 NLTHLSLKYNNLTEVPRR---LPPSLDTLLLSYNHIVTLAPEDLANLTALRVLDVGGNCR 235 Query: 126 --------------NIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLR 171 N + TF L L L L +++L L KD F+GL L +DL Sbjct: 236 RCDHARNPCRECPKNFPKLHPDTFSHLSRLEGLVLKDSSLYKLEKDWFRGLGRLQVLDLS 295 Query: 172 GN 173 N Sbjct: 296 EN 297 Score = 28.9 bits (63), Expect = 6.3, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 26/42 (61%), Gaps = 1/42 (2%) Query: 135 FRGLKSLIHLSLANNNLQT-LPKDIFKGLDSLTNVDLRGNSF 175 F+GL++L+ L L+ N+L T LP+ + SL + LR N+ Sbjct: 602 FKGLRNLVQLDLSENHLHTLLPRHLDNLPKSLRQLRLRDNNL 643 >5JNF-C nrPDB Length = 587 Score = 34.3 bits (77), Expect = 0.16, Method: Compositional matrix adjust. Identities = 36/133 (27%), Positives = 57/133 (42%), Gaps = 27/133 (20%) Query: 8 RMGNACIPL------KRIAYFLCLLSA-LLLTEG--KKPAKPKCPAVCTCTKDNALCENA 58 + G A +P+ +RIAY L SA +LLT ++ A C + D + EN Sbjct: 277 KAGGAYVPIDPDYPGERIAYMLADSSAAILLTNALHEEKANGACDIIDVHDPD-SYSENT 335 Query: 59 RSIPRTVPPDVISLSFVRSGFTEISEGS-----------------FLFTPSLQLLLFTSN 101 ++P PD + SG T +++G F TP+ + L+++S Sbjct: 336 NNLPHVNRPDDLVYVMYTSGSTGLAKGVMIEHHNLVNFCEWYRPYFGVTPADKALVYSSF 395 Query: 102 SFDVISDDAFIGL 114 SFD + D F L Sbjct: 396 SFDGSALDIFTHL 408 >5ES8-A nrPDB Length = 776 Score = 33.9 bits (76), Expect = 0.17, Method: Compositional matrix adjust. Identities = 36/133 (27%), Positives = 57/133 (42%), Gaps = 27/133 (20%) Query: 8 RMGNACIPL------KRIAYFLCLLSA-LLLTEG--KKPAKPKCPAVCTCTKDNALCENA 58 + G A +P+ +RIAY L SA +LLT ++ A C + D + EN Sbjct: 275 KAGGAYVPIDPDYPGERIAYMLADSSAAILLTNALHEEKANGACDIIDVHDPD-SYSENT 333 Query: 59 RSIPRTVPPDVISLSFVRSGFTEISEGS-----------------FLFTPSLQLLLFTSN 101 ++P PD + SG T +++G F TP+ + L+++S Sbjct: 334 NNLPHVNRPDDLVYVMYTSGSTGLAKGVMIEHHNLVNFCEWYRPYFGVTPADKALVYSSF 393 Query: 102 SFDVISDDAFIGL 114 SFD + D F L Sbjct: 394 SFDGSALDIFTHL 406 >5ES6-A nrPDB Length = 685 Score = 33.9 bits (76), Expect = 0.20, Method: Compositional matrix adjust. Identities = 36/133 (27%), Positives = 57/133 (42%), Gaps = 27/133 (20%) Query: 8 RMGNACIPL------KRIAYFLCLLSA-LLLTEG--KKPAKPKCPAVCTCTKDNALCENA 58 + G A +P+ +RIAY L SA +LLT ++ A C + D + EN Sbjct: 275 KAGGAYVPIDPDYPGERIAYMLADSSAAILLTNALHEEKANGACDIIDVHDPD-SYSENT 333 Query: 59 RSIPRTVPPDVISLSFVRSGFTEISEGS-----------------FLFTPSLQLLLFTSN 101 ++P PD + SG T +++G F TP+ + L+++S Sbjct: 334 NNLPHVNRPDDLVYVMYTSGSTGLAKGVMIEHHNLVNFCEWYRPYFGVTPADKALVYSSF 393 Query: 102 SFDVISDDAFIGL 114 SFD + D F L Sbjct: 394 SFDGSALDIFTHL 406 >3WPI-A nrPDB Length = 803 Score = 33.1 bits (74), Expect = 0.33, Method: Compositional matrix adjust. Identities = 30/127 (23%), Positives = 57/127 (44%), Gaps = 12/127 (9%) Query: 60 SIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSF--------DVISDDAF 111 ++PR +P +++LS + + S SL++L N + ++ A Sbjct: 116 TVPR-LPSSLVNLSLSHTNILVLDANSLAGLYSLRVLFMDGNCYYKNPCTGAVKVTPGAL 174 Query: 112 IGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLR 171 +GL L +L ++ NN+ + R L+ L+ ++ N + L + L SL +D+ Sbjct: 175 LGLSQLTHLSLKYNNLTKVPRQLPPSLEYLL---VSYNLIVKLGPEDLAQLTSLRVLDVG 231 Query: 172 GNSFNCD 178 GN CD Sbjct: 232 GNCRRCD 238 Score = 28.5 bits (62), Expect = 8.3, Method: Compositional matrix adjust. Identities = 21/70 (30%), Positives = 35/70 (50%), Gaps = 4/70 (5%) Query: 106 ISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSL 165 I F+ + LE L + N I ++ R SL++LSL++ N+ L + GL SL Sbjct: 93 IEPRTFLAMRTLEELNLSYNGITTVPRLP----SSLVNLSLSHTNILVLDANSLAGLYSL 148 Query: 166 TNVDLRGNSF 175 + + GN + Sbjct: 149 RVLFMDGNCY 158 >1JL5-A nrPDB Length = 454 Score = 31.2 bits (69), Expect = 1.4, Method: Compositional matrix adjust. Identities = 32/123 (26%), Positives = 60/123 (48%), Gaps = 18/123 (14%) Query: 78 GFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPH-LEYLFIENNNIKSISRHTFR 136 G + + E P L+ L+ + NS + + LP L+ L ++NNN+K++S Sbjct: 82 GLSSLPE----LPPHLESLVASCNSLTELPE-----LPQSLKSLLVDNNNLKALS----- 127 Query: 137 GLKSLI-HLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATV 195 L L+ +L ++NN L+ LP+ + L +D+ NS L +E++ N + Sbjct: 128 DLPPLLEYLGVSNNQLEKLPE--LQNSSFLKIIDVDNNSLKKLPDLPPSLEFIAAGNNQL 185 Query: 196 EDI 198 E++ Sbjct: 186 EEL 188 >5Y6P-24 nrPDB Length = 371 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 7/62 (11%) Query: 304 GGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWN 363 GGS I K S + KF K++++ P + TF+ NN Y V D A + I+K Sbjct: 310 GGSGI-KLQSRSGKFYKMRNM------APAKVSTFRRANNVYLVPFDELSATYIKIHKNG 362 Query: 364 GN 365 G+ Sbjct: 363 GS 364 >6ICZ-o nrPDB Length = 255 Score = 29.6 bits (65), Expect = 3.2, Method: Compositional matrix adjust. Identities = 30/85 (35%), Positives = 37/85 (43%), Gaps = 9/85 (10%) Query: 91 PSLQLLLFTSNSFDVI--SD------DAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLI 142 P ++ L T + FD I SD D F L L+ L + NN I I + L L Sbjct: 32 PVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCLT 91 Query: 143 HLSLANNNLQTLPK-DIFKGLDSLT 166 L L NN+L L D L SLT Sbjct: 92 ELILTNNSLVELGDLDPLASLKSLT 116 >1M9S-A nrPDB Length = 605 Score = 29.3 bits (64), Expect = 4.8, Method: Compositional matrix adjust. Identities = 24/69 (34%), Positives = 33/69 (47%), Gaps = 5/69 (7%) Query: 106 ISD-DAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDS 164 ISD + + LP LE L++ NN I I+ L L LSL +N + + GL Sbjct: 121 ISDINGLVHLPQLESLYLGNNKITDIT--VLSRLTKLDTLSLEDNQISDIVP--LAGLTK 176 Query: 165 LTNVDLRGN 173 L N+ L N Sbjct: 177 LQNLYLSKN 185 >6IOL-A nrPDB Length = 474 Score = 28.9 bits (63), Expect = 6.7, Method: Compositional matrix adjust. Identities = 16/42 (38%), Positives = 23/42 (54%) Query: 71 SLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFI 112 ++S SG + GS+LF PS+ L +FT+ S D A I Sbjct: 308 TMSRQLSGLFDAGSGSWLFQPSINLPIFTAGSLRASLDYAKI 349 >3JB9-j nrPDB Length = 239 Score = 28.5 bits (62), Expect = 7.0, Method: Compositional matrix adjust. Identities = 23/72 (31%), Positives = 34/72 (47%), Gaps = 3/72 (4%) Query: 98 FTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPK- 156 FT N + + F + L+ L NN I +I+ + L +L LSLA N+LQ + Sbjct: 48 FTDNDIRYLGN--FPRMKRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIADL 105 Query: 157 DIFKGLDSLTNV 168 D LTN+ Sbjct: 106 DPLASCPQLTNL 117 >4FGR-A nrPDB Length = 255 Score = 28.5 bits (62), Expect = 8.4, Method: Compositional matrix adjust. Identities = 33/147 (22%), Positives = 65/147 (44%), Gaps = 15/147 (10%) Query: 63 RTVPPDVISLSFVRSGFTE---ISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEY 119 + +P +V+ ++ F++ + EG L TP ++ F + D+ DD FI H+++ Sbjct: 104 KIIPLEVVLRNYTAGSFSKRFGVDEGIALETPIVE---FYYKNDDL--DDPFINDEHVKF 158 Query: 120 LFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCD- 178 L I + + + R + L+ + A L+ + + G D + L + F+ D Sbjct: 159 LQIAGDQQIAYLKEETRRINELLKVWFAEIGLKLIDFKLEFGFDKDGKIIL-ADEFSPDN 217 Query: 179 CKLKWLVEWLGHTNATVEDIYCEGPPE 205 C+L W N +D++ G E Sbjct: 218 CRL-----WDADGNHMDKDVFRRGLGE 239 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5Y31-B nrPDB 941 0.0 2V9T-B nrPDB 184 1e-46 1XCD-A nrPDB 163 2e-40 2FT3-A nrPDB 156 2e-38 5ZSN-B nrPDB 155 5e-38 2XOT-A nrPDB 145 4e-35 5GY2-A nrPDB 143 2e-34 5MX0-A nrPDB 139 2e-33 5LFN-A nrPDB 131 6e-31 3T6Q-A nrPDB 131 7e-31 4R6F-A nrPDB 130 2e-30 3J0A-A nrPDB 128 6e-30 3RG1-A nrPDB 128 6e-30 5D3I-A nrPDB 124 8e-29 3A7C-A nrPDB 124 1e-28 4PBW-B nrPDB 122 3e-28 2Z7X-B nrPDB 122 4e-28 3A79-B nrPDB 121 8e-28 2Z80-A nrPDB 120 1e-27 2Z7X-A nrPDB 119 3e-27 3ULU-A nrPDB 118 8e-27 3CIG-A nrPDB 117 2e-26 3V44-A nrPDB 111 7e-25 6GFF-I nrPDB 106 2e-23 4AY9-X nrPDB 100 1e-21 1XWD-C nrPDB 100 2e-21 6O00-A nrPDB 99 5e-21 2IFG-A nrPDB 97 2e-20 Sequences not found previously or not previously below threshold: 4R08-A nrPDB 117 1e-26 4QDH-A nrPDB 116 2e-26 4PBV-A nrPDB 115 4e-26 3B2D-A nrPDB 115 7e-26 5Y3K-A nrPDB 100 2e-21 5Y3M-A nrPDB 97 2e-20 5YQ5-A nrPDB 81 1e-15 3WPI-A nrPDB 79 6e-15 6HLU-A nrPDB 75 1e-13 5XJX-C nrPDB 68 9e-12 4PUF-A nrPDB 67 1e-11 6HKW-A nrPDB 67 2e-11 3CVR-A nrPDB 61 1e-09 1M9S-A nrPDB 59 6e-09 1OGQ-A nrPDB 56 4e-08 3G06-A nrPDB 55 6e-08 6ICZ-o nrPDB 53 4e-07 3JB9-j nrPDB 52 5e-07 1JL5-A nrPDB 52 5e-07 5KH1-A nrPDB 51 2e-06 5YXM-A nrPDB 50 2e-06 4ECN-A nrPDB 48 9e-06 5LJ5-W nrPDB 45 7e-05 3G04-C nrPDB 44 1e-04 1DCE-A nrPDB 43 3e-04 1KOH-A nrPDB 42 0.001 4WYK-A nrPDB 41 0.001 3TSR-E nrPDB 41 0.001 2BNH-A nrPDB 40 0.002 2Q4G-W nrPDB 36 0.042 4PEQ-B nrPDB 36 0.044 1DL5-A nrPDB 35 0.11 6MDV-A nrPDB 35 0.11 6J5T-G nrPDB 34 0.20 2CA6-A nrPDB 33 0.35 1JSW-A nrPDB 33 0.36 6FE8-D nrPDB 33 0.47 2P1O-B nrPDB 33 0.48 5YIX-A nrPDB 32 0.64 4NUY-A nrPDB 32 1.0 5Y6P-24 nrPDB 31 1.2 >5Y31-B nrPDB Length = 544 Score = 941 bits (2432), Expect = 0.0, Method: Composition-based stats. Identities = 520/521 (99%), Positives = 520/521 (99%) Query: 37 PAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLL 96 PAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLL Sbjct: 17 PAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLL 76 Query: 97 LFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPK 156 LFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPK Sbjct: 77 LFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPK 136 Query: 157 DIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSS 216 DIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSS Sbjct: 137 DIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSS 196 Query: 217 KDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYD 276 KDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYD Sbjct: 197 KDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYD 256 Query: 277 NITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIE 336 NITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIE Sbjct: 257 NITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIE 316 Query: 337 TFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRT 396 TFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRT Sbjct: 317 TFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRT 376 Query: 397 PHLILSSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSK 456 PHLILSSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSK Sbjct: 377 PHLILSSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSK 436 Query: 457 VMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQE 516 VMKWGGSSFQDIQ MPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQE Sbjct: 437 VMKWGGSSFQDIQAMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQE 496 Query: 517 LNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA 557 LNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA Sbjct: 497 LNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA 537 >2V9T-B nrPDB Length = 220 Score = 184 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 55/206 (26%), Positives = 85/206 (41%), Gaps = 26/206 (12%) Query: 42 CPAVCTCTKDNALC--ENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFT 99 CPA CTC+ + C + IP +P + + ++ I G+F L+ + + Sbjct: 5 CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLS 64 Query: 100 SNSFDVISDDAFIGLPHLEYLFIENNNIKSISR------------------------HTF 135 +N ++ DAF GL L L + N I + + F Sbjct: 65 NNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAF 124 Query: 136 RGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATV 195 + L +L LSL +N LQT+ K F L ++ + L N F CDC LKWL ++L Sbjct: 125 QDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIET 184 Query: 196 EDIYCEGPPEYKKRKINSLSSKDFDC 221 C P ++I + SK F C Sbjct: 185 SGARCTSPRRLANKRIGQIKSKKFRC 210 >1XCD-A nrPDB Length = 329 Score = 163 bits (413), Expect = 2e-40, Method: Composition-based stats. Identities = 49/220 (22%), Positives = 86/220 (39%), Gaps = 13/220 (5%) Query: 36 KPAKPKCPAVCTCTKDNALCENA--RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSL 93 +P P CP C C C + +P+ +PPD L + TEI +G F +L Sbjct: 19 EPMGPVCPFRCQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNL 78 Query: 94 QLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQT 153 L+ +N IS AF L LE L++ N +K + + K+L L + N + Sbjct: 79 HTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELPE---KMPKTLQELRVHENEITK 135 Query: 154 LPKDIFKGLDSLTNVDLRGNSFNCD-CKLKWLV-----EWLGHTNATVEDIYCEGPPEYK 207 + K +F GL+ + V+L N + ++ + + I PP Sbjct: 136 VRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLT 195 Query: 208 KRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYLND 247 + ++ D +L LS ++ S +++ Sbjct: 196 ELHLDGNKITKVDA--ASLKGLNNLAKLGLSFNSISAVDN 233 Score = 77.0 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 24/105 (22%), Positives = 44/105 (41%), Gaps = 1/105 (0%) Query: 57 NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPH 116 N +IP+ +PP + L + T++ S +L L + NS + + + PH Sbjct: 182 NITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH 241 Query: 117 LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKG 161 L L + NN + + K + + L NNN+ + + F Sbjct: 242 LRELHLNNNKLVKVPGGLADH-KYIQVVYLHNNNISAIGSNDFCP 285 >2FT3-A nrPDB Length = 332 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 39/175 (22%), Positives = 74/175 (42%), Gaps = 5/175 (2%) Query: 42 CPAVCTCTKDNALCENA--RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFT 99 CP C C C + +++P+ + PD L + +E+ + F L L+ Sbjct: 27 CPFGCHCHLRVVQCSDLGLKAVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLV 86 Query: 100 SNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIF 159 +N I + AF L L+ L+I N++ I + SL+ L + +N ++ +PK +F Sbjct: 87 NNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNL---PSSLVELRIHDNRIRKVPKGVF 143 Query: 160 KGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSL 214 GL ++ +++ GN + L + + G P+ +N L Sbjct: 144 SGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETLNEL 198 Score = 76.2 bits (186), Expect = 3e-14, Method: Composition-based stats. Identities = 23/105 (21%), Positives = 38/105 (36%), Gaps = 1/105 (0%) Query: 57 NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPH 116 IP+ +P + L + I L L L N +I + + LP Sbjct: 183 KLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPT 242 Query: 117 LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKG 161 L L ++NN + + LK L + L NN+ + + F Sbjct: 243 LRELHLDNNKLSRVPAGLP-DLKLLQVVYLHTNNITKVGVNDFCP 286 Score = 68.9 bits (167), Expect = 6e-12, Method: Composition-based stats. Identities = 28/160 (17%), Positives = 45/160 (28%), Gaps = 47/160 (29%) Query: 60 SIPRTVPPDVISLSFVRSGFTEISEGSFLFTPS--------------------------- 92 IP +P ++ L + ++ +G F + Sbjct: 116 EIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLN 175 Query: 93 -------------------LQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRH 133 L L N I + + L L + +N I+ I Sbjct: 176 YLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENG 235 Query: 134 TFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173 + L +L L L NN L +P + L L V L N Sbjct: 236 SLSFLPTLRELHLDNNKLSRVPAGL-PDLKLLQVVYLHTN 274 >5ZSN-B nrPDB Length = 823 Score = 155 bits (392), Expect = 5e-38, Method: Composition-based stats. Identities = 41/157 (26%), Positives = 76/157 (48%), Gaps = 6/157 (3%) Query: 64 TVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIE 123 +PP++ +LS ++G + +L+ L + N + + L+ L ++ Sbjct: 650 GMPPNLKNLSLAKNGLKSFIWEKLRYLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILK 709 Query: 124 NNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKG--LDSLTNVDLRGNSFNCDCKL 181 NN I+S++++ + L +L L++N +Q + K F L++L + L N F C C Sbjct: 710 NNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDA 769 Query: 182 KWLVEWLGHTNATVE----DIYCEGPPEYKKRKINSL 214 W V W+ HT T+ D+ C GP +K + + SL Sbjct: 770 VWFVWWVQHTEVTIPYLATDVTCVGPGAHKGQSVISL 806 Score = 82.8 bits (203), Expect = 4e-16, Method: Composition-based stats. Identities = 31/136 (22%), Positives = 54/136 (39%), Gaps = 19/136 (13%) Query: 57 NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFT----------------- 99 N ++P +P + L + EI E F LQ+L + Sbjct: 193 NVTTVPTVLPSTLTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCTPCK 252 Query: 100 SNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNL--QTLPKD 157 +NS I +AF L L+ L + +N+++ + F+ + +L L L+ N L + Sbjct: 253 NNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFLAKEIGDAK 312 Query: 158 IFKGLDSLTNVDLRGN 173 L +L +DL N Sbjct: 313 FLHFLPNLIQLDLSFN 328 Score = 70.1 bits (170), Expect = 3e-12, Method: Composition-based stats. Identities = 33/134 (24%), Positives = 57/134 (42%), Gaps = 18/134 (13%) Query: 60 SIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSF--------DVISDDAF 111 IP+ +PP + LS + I + ++++L N + I DAF Sbjct: 119 EIPQGLPPSLQLLSLEANNIFSIRKEQLTELANIEILYLGQNCYYRNPCYVSYSIEKDAF 178 Query: 112 IGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLR 171 + L L+ L +++NN+ ++ +L L L NN + + +D F L+ L +DL Sbjct: 179 LNLTKLKVLSLKDNNVTTVPTVL---PSTLTELYLYNNMIAEIQEDDFNNLNQLQILDLS 235 Query: 172 GN-------SFNCD 178 GN F C Sbjct: 236 GNCPRCYNAPFPCT 249 Score = 67.0 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 42/214 (19%), Positives = 83/214 (38%), Gaps = 38/214 (17%) Query: 69 VISLSFVRSGFTEISEGS-FLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENN-- 125 + L+ + ++ GS F L+ L F++N D++ AF L LE L I +N Sbjct: 497 LKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELRKLEVLDISSNSH 556 Query: 126 -----NIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNC--- 177 I + + + LK L L + +N++ + + +SL ++ RGN + Sbjct: 557 YFQSEGITHM-LNFTKNLKVLQKLMMNDNDISSSTSRTMES-ESLRTLEFRGNHLDVLWR 614 Query: 178 DCKLKWLVEWLGHTNATVEDI--------------YCEGPPEYKKRKINSLSSKDFDCII 223 D ++L L +E++ + PP K SL+ I Sbjct: 615 DGDNRYLQ--LFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNL---SLAKNGLKSFI 669 Query: 224 TEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFT 257 E K + L +++T +++ + + + Sbjct: 670 WE--KLRYLK----NLETLDLSHNQLTTVPERLS 697 Score = 60.1 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 1/82 (1%) Query: 94 QLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIK-SISRHTFRGLKSLIHLSLANNNLQ 152 Q L + NS I F L L+ L + N I +++ F+ L L +L +NN L Sbjct: 474 QTLDLSKNSIFFIKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLD 533 Query: 153 TLPKDIFKGLDSLTNVDLRGNS 174 L F+ L L +D+ NS Sbjct: 534 LLHSTAFEELRKLEVLDISSNS 555 Score = 57.8 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 46/248 (18%), Positives = 89/248 (35%), Gaps = 42/248 (16%) Query: 37 PAKPKCPAVCTCTKDNAL--C--ENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPS 92 P C +K++ + C ++ IP +P + +L+ + +IS SF Sbjct: 9 PKTLPCDVTLDVSKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLVH 68 Query: 93 LQLLLFTSNSF--------------DVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGL 138 L + F N I +F GL +L+ L+++ N + I + L Sbjct: 69 LVEIDFRCNCVPIRLGSKSNMCPRRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSL 128 Query: 139 KSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDI 198 + L NN+ ++ K+ L ++ + L N C + V + +A + Sbjct: 129 QLLSL---EANNIFSIRKEQLTELANIEILYLGQN---CYYRNPCYVSYSIEKDAFL--- 179 Query: 199 YCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSI------DTFSYLNDEYVVI 252 K K+ SL + + T + Y ++ D F+ LN ++ Sbjct: 180 ------NLTKLKVLSLKDNNVTTVPTVLPSTLTELYLYNNMIAEIQEDDFNNLNQLQIL- 232 Query: 253 AQPFTGKC 260 +G C Sbjct: 233 --DLSGNC 238 Score = 57.0 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 30/117 (25%), Positives = 46/117 (39%), Gaps = 11/117 (9%) Query: 68 DVISLSFVRSGF-TEISEGSFL-FTPSLQLLLFTSN---SFDVISDD---AFIGLPHLEY 119 ++ L ++ EI + FL F P+L L + N S + AF L L+ Sbjct: 293 NLQELDLSQNFLAKEIGDAKFLHFLPNLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKI 352 Query: 120 LFIEN---NNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173 L I +KS L++L L L N ++ +FK L +DL N Sbjct: 353 LRIRGYVFKELKSFQLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVN 409 Score = 47.7 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 1/60 (1%) Query: 118 EYLFIENNNIKSISRHTFRGLKSLIHLSLANNNL-QTLPKDIFKGLDSLTNVDLRGNSFN 176 + L + N+I I F+ L L L+L+ N + QTL F+ L L +D N + Sbjct: 474 QTLDLSKNSIFFIKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLD 533 Score = 42.7 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 21/107 (19%), Positives = 36/107 (33%), Gaps = 9/107 (8%) Query: 67 PDVISLSFVRSGFTEISEGS------FLFTPSLQLLLFTS---NSFDVISDDAFIGLPHL 117 P++I L + ++ S F SL++L L +L Sbjct: 318 PNLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFQLSPLHNLQNL 377 Query: 118 EYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDS 164 E L + N IK + F+ K L + L+ N + + S Sbjct: 378 EVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSLVPRGSS 424 >2XOT-A nrPDB Length = 361 Score = 145 bits (367), Expect = 4e-35, Method: Composition-based stats. Identities = 44/200 (22%), Positives = 86/200 (43%), Gaps = 22/200 (11%) Query: 42 CPAVCTCTKDNALCENAR--SIPRTVPPDVISLSFVRSGFTEIS-EGSFLFTPSLQLLLF 98 CPA C C + C + ++P+++P L + + + E + +L LL Sbjct: 12 CPANCLCASNILSCSKQQLPNVPQSLPSYTALLDLSHNNLSRLRAEWTPTRLTNLHSLLL 71 Query: 99 TSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDI 158 + N + IS +AF+ +P+L YL + +N++ ++ F L++L L L NN++ + ++ Sbjct: 72 SHNHLNFISSEAFVPVPNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNA 131 Query: 159 FKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKD 218 F+ + L + L N + ++ VE + N + K + LSS Sbjct: 132 FEDMAQLQKLYLSQNQIS-----RFPVELIKDGN------------KLPKLMLLDLSSNK 174 Query: 219 FDCIITEFAKSQDLPYQSLS 238 + Q LP + Sbjct: 175 LKKLP--LTDLQKLPAWVKN 192 >5GY2-A nrPDB Length = 455 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 38/140 (27%), Positives = 66/140 (47%), Gaps = 2/140 (1%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI 127 D+ L+ ++ +I + +F L L + N I F L LE L + N+I Sbjct: 300 DLEQLTLAQNEINKIDDNAFWGLTHLLKLNLSQNFLGSIDSRMFENLDKLEVLDLSYNHI 359 Query: 128 KSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDC-KLKWLVE 186 +++ +F GL +L L+L N L+++P IF L SL + L N ++C C ++ +L Sbjct: 360 RALGDQSFLGLPNLKELALDTNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLSR 419 Query: 187 WLGHTNATVEDIY-CEGPPE 205 WL + + C G + Sbjct: 420 WLNKNSQKEQGSAKCSGSGK 439 Score = 78.2 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 47/233 (20%), Positives = 84/233 (36%), Gaps = 47/233 (20%) Query: 45 VCTCTKDNALC--ENARSIPRTVPPDVISLSFVRSGFTE--------------------- 81 C+ NA+C +P +P V + + E Sbjct: 7 ECSVIGYNAICINRGLHQVP-ELPAHVNYVDLSLNSIAELNETSFSRLQDLQFLKVEQQT 65 Query: 82 ----ISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKS--ISRHTF 135 I +F SL +L N F + AF GL +LE L + N+ +S + F Sbjct: 66 PGLVIRNNTFRGLSSLIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFF 125 Query: 136 RGLKSLIHLSLANNNLQTL-PKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNAT 194 + L SL L L +NN++ + P F + +DL N C+ Sbjct: 126 KPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLTFNKVKSICE-------------- 171 Query: 195 VEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYLND 247 ED+ + +++S++ +D + + K + P+++ SI T + Sbjct: 172 -EDLLNFQGKHFTLLRLSSITLQDMNEYWLGWEKCGN-PFKNTSITTLDLSGN 222 Score = 59.7 bits (143), Expect = 4e-09, Method: Composition-based stats. Identities = 45/238 (18%), Positives = 79/238 (33%), Gaps = 57/238 (23%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD--VISDDAFIGLPHLEYLFIEN 124 +I L + F ++ G+F +L++L T + D V+S + F L LE L + + Sbjct: 79 SSLIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRD 138 Query: 125 NNIKSI-SRHTFRGLKSLIHLSLANNNLQTL------------------PKDIFKGL--- 162 NNIK I F ++ L L N ++++ + + Sbjct: 139 NNIKKIQPASFFLNMRRFHVLDLTFNKVKSICEEDLLNFQGKHFTLLRLSSITLQDMNEY 198 Query: 163 -------------DSLTNVDLRGNSFNCDCKLKWLV-------------------EWLGH 190 S+T +DL GN F ++ GH Sbjct: 199 WLGWEKCGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAGTKIQSLILSNSYNMGSSFGH 258 Query: 191 TNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAK-SQDLPYQSLSIDTFSYLND 247 TN D + E K LS ++ DL +L+ + + ++D Sbjct: 259 TNFKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDD 316 Score = 33.9 bits (76), Expect = 0.20, Method: Composition-based stats. Identities = 8/36 (22%), Positives = 16/36 (44%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNS 102 P++ L+ + + +G F SLQ + +N Sbjct: 371 PNLKELALDTNQLKSVPDGIFDRLTSLQKIWLHTNP 406 >5MX0-A nrPDB Length = 362 Score = 139 bits (351), Expect = 2e-33, Method: Composition-based stats. Identities = 55/258 (21%), Positives = 98/258 (37%), Gaps = 51/258 (19%) Query: 37 PAKPK-CPAVCTCTKD---NALCENA--RSIPRTVPPDVISLSFVRSGFTEISEGSFLFT 90 P P+ CP C C + C+N + +P VP + + F + T I EG F Sbjct: 56 PPDPRDCPQECDCPPNFPTAMYCDNRNLKYLP-FVPSRMKYVYFQNNQITSIQEGVFDNA 114 Query: 91 PSLQLLLFTSNSF--DVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLAN 148 L + N D + F L HLE L++++NN+ + +SL L L + Sbjct: 115 TGLLWIALHGNQITSDKVGRKVFSKLRHLERLYLDHNNLTRMPGPL---PRSLRELHLDH 171 Query: 149 NNLQTLPKDIFKGLDSLTNVDLRGNSF-NCDCKLKWL----------------------- 184 N + +P + +GL++LT + L+ N ++ L Sbjct: 172 NQISRVPNNALEGLENLTALYLQHNEIQEVGSSMRGLRSLILLDLSYNHLRKVPDGLPSA 231 Query: 185 --VEWLGHTNA-TVEDIYCEGPPE--YKKRKINSLSSKDFDC----------IITEFAKS 229 ++ H N TV D Y G P+ Y + NSL++ + + + Sbjct: 232 LEQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNSLTNNGLASNTFNSSSLLELDLSYNQL 291 Query: 230 QDLPYQSLSIDTFSYLND 247 Q +P + +++ + Sbjct: 292 QKIPPVNTNLENLYLQGN 309 Score = 55.8 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 23/124 (18%), Positives = 42/124 (33%), Gaps = 13/124 (10%) Query: 58 ARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSF--DVISDDAFIGLP 115 R +P +P + L + + + F P L + + NS + ++ + F Sbjct: 221 LRKVPDGLPSALEQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNSLTNNGLASNTFNSSS 280 Query: 116 HLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIF------KGLDSLTNVD 169 LE + N ++ I +L +L L N + F L + Sbjct: 281 LLEL-DLSYNQLQKIPP----VNTNLENLYLQGNRINEFSISSFCTVVDVVNFSKLQVLR 335 Query: 170 LRGN 173 L GN Sbjct: 336 LDGN 339 >5LFN-A nrPDB Length = 337 Score = 131 bits (330), Expect = 6e-31, Method: Composition-based stats. Identities = 40/148 (27%), Positives = 67/148 (45%), Gaps = 4/148 (2%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGL-PHLEYLFIENN 125 ++ R+ + + ++ L + N I D+AF +LE L+++N Sbjct: 173 ENLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNT 232 Query: 126 NIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLV 185 N++ S F G+ +L H+ L NN L LP + DSL + L N + C C+L+ L Sbjct: 233 NLEKFSDGAFLGVTTLKHVHLENNRLNQLPSNF--PFDSLETLALTNNPWKCTCQLRGLR 290 Query: 186 EWLGHTNATVEDIYCEGPPEYKKRKINS 213 WL A+ D C P ++K + I Sbjct: 291 RWL-EAKASRPDATCASPAKFKGQHIRD 317 Score = 125 bits (315), Expect = 4e-29, Method: Composition-based stats. Identities = 43/166 (25%), Positives = 71/166 (42%), Gaps = 15/166 (9%) Query: 42 CPAVCTCTKD--NALCE--NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLL 97 CP C C D + +C+ + IP+ V L+ R+ F ++ SF P+L L Sbjct: 1 CPQNCHCHSDLQHVICDKVGLQKIPK-VSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLH 59 Query: 98 FTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD 157 ++ AF GL L YL++ +N+I+ + F L L +L L +N + LP+ Sbjct: 60 LQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRG 119 Query: 158 IFKGLDSLTNVDLRGNS--------FNCDCKLKWLVEWLGHTNATV 195 + L +L + L N F L+WL +L + Sbjct: 120 LLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWL--YLSENALSS 163 >3T6Q-A nrPDB Length = 606 Score = 131 bits (330), Expect = 7e-31, Method: Composition-based stats. Identities = 33/155 (21%), Positives = 67/155 (43%), Gaps = 7/155 (4%) Query: 67 PDVISLSFVRSGFTE---ISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIE 123 P + L+ + F + S L++L+ + I AF L + ++ + Sbjct: 449 PALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAFTSLKMMNHVDLS 508 Query: 124 NNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKW 183 +N + S S LK + +L+LA+N++ + + L ++LR N +C C + Sbjct: 509 HNRLTSSSIEALSHLKGI-YLNLASNHISIILPSLLPILSQQRTINLRQNPLDCTCSNIY 567 Query: 184 LVEWLGHTNATV---EDIYCEGPPEYKKRKINSLS 215 +EW + ED CE PP + +++ ++ Sbjct: 568 FLEWYKENMQKLEDTEDTLCENPPLLRGVRLSDVT 602 Score = 72.4 bits (176), Expect = 4e-13, Method: Composition-based stats. Identities = 51/243 (20%), Positives = 85/243 (34%), Gaps = 36/243 (14%) Query: 50 KDNALCENA--RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVIS 107 CEN IP T+P L F + I +F +L L T I Sbjct: 14 NKTYNCENLGLNEIPGTLPNSTECLEFSFNVLPTIQNTTFSRLINLTFLDLTRCQIYWIH 73 Query: 108 DDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIH------------------------ 143 +D F L+ L + N + ++ G K+L H Sbjct: 74 EDTFQSQHRLDTLVLTANPLIFMAETALSGPKALKHLFFIQTGISSIDFIPLHNQKTLES 133 Query: 144 LSLANNNLQTL--PKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATV----ED 197 L L +N++ ++ PK + L +D + N+ + K + TN ++ D Sbjct: 134 LYLGSNHISSIKLPKGF--PTEKLKVLDFQNNAIHYLSKED-MSSLQQATNLSLNLNGND 190 Query: 198 IYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFT 257 I P + SL+ ++ F ++ QSL + TF ++DE + F Sbjct: 191 IAGIEPGAFDSAVFQSLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDMDDEDIS-PAVFE 249 Query: 258 GKC 260 G C Sbjct: 250 GLC 252 Score = 57.8 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 26/125 (20%), Positives = 46/125 (36%), Gaps = 4/125 (3%) Query: 56 ENARSIPRTVPPDVISLSFVRSGFT-EISEGSFLFTPSLQLLLFTSNSFDVIS--DDAFI 112 EN I + P + LS + E+ G +L+ L + + + + Sbjct: 314 ENLCQISASNFPSLTHLSIKGNTKRLELGTGCLENLENLRELDLSHDDIETSDCCNLQLR 373 Query: 113 GLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDI-FKGLDSLTNVDLR 171 L HL+ L + N S+ F+ L L LA L+ F+ L L ++L Sbjct: 374 NLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKDAQSPFQNLHLLKVLNLS 433 Query: 172 GNSFN 176 + + Sbjct: 434 HSLLD 438 Score = 54.3 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 44/266 (16%), Positives = 80/266 (30%), Gaps = 68/266 (25%) Query: 60 SIPRTVP-PDVISLSFVRSGFTEISEGSFLFT---PSLQLLLFTSNSFDVISDDAF---- 111 +P+ P + L F + +S+ +L L N I AF Sbjct: 145 KLPKGFPTEKLKVLDFQNNAIHYLSKEDMSSLQQATNL-SLNLNGNDIAGIEPGAFDSAV 203 Query: 112 ----------------IGLPH-------------------------------LEYLFIEN 124 GL + +E + ++ Sbjct: 204 FQSLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDMDDEDISPAVFEGLCEMSVESINLQK 263 Query: 125 NNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLK-- 182 + +IS +TF L L L +L LP + GL +L + L N F C++ Sbjct: 264 HYFFNISSNTFHCFSGLQELDLTATHLSELPSGLV-GLSTLKKLVLSANKFENLCQISAS 322 Query: 183 ---WLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLS- 238 L N ++ + + LS D E + +L ++LS Sbjct: 323 NFPSLTHLSIKGNTKRLELGTGCLENLENLRELDLSHDDI-----ETSDCCNLQLRNLSH 377 Query: 239 IDTFSYLNDEYVVIAQPFTGKCIFLE 264 + + + +E + + +C LE Sbjct: 378 LQSLNLSYNEPLSLKTEAFKECPQLE 403 Score = 48.9 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 25/124 (20%), Positives = 45/124 (36%), Gaps = 5/124 (4%) Query: 58 ARSIPRTVP--PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD-VISDDAFIGL 114 +P + + L + F + + S PSL L N+ + L Sbjct: 290 LSELPSGLVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTKRLELGTGCLENL 349 Query: 115 PHLEYLFIENNNIKSIS--RHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRG 172 +L L + +++I++ R L L L+L+ N +L + FK L +DL Sbjct: 350 ENLRELDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAF 409 Query: 173 NSFN 176 Sbjct: 410 TRLK 413 >4R6F-A nrPDB Length = 331 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 49/213 (23%), Positives = 83/213 (38%), Gaps = 39/213 (18%) Query: 58 ARSIPRTVPPDV---ISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDA---- 110 S+P+ V + +L+ + I++ +L L + N+ + A Sbjct: 121 LTSLPQGVFERLASLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGG 180 Query: 111 ----FIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLT 166 GL +L L + +N I R F+ L SL L+L+NNN+ + + +GL +LT Sbjct: 181 PIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNNIANINDQMLEGLTNLT 240 Query: 167 NVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKIN-----SLSSKDFDC 221 ++L N A + G P Y + + +LSS FD Sbjct: 241 TLNLSHN-----------------NLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDE 283 Query: 222 IITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQ 254 I E K DL S+ T + N++ + Q Sbjct: 284 IPREVFK--DLT----SLTTLNLSNNQLTSLPQ 310 Score = 118 bits (297), Expect = 4e-27, Method: Composition-based stats. Identities = 48/191 (25%), Positives = 79/191 (41%), Gaps = 30/191 (15%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNN 126 P+V L+ + +IS + +L L ++N + + F L +L L + NN Sbjct: 63 PNVRYLALGGNKLHDIS--ALKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQ 120 Query: 127 IKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVE 186 + S+ + F L SL L+L+NNN+ + + +GL +LT ++L N Sbjct: 121 LTSLPQGVFERLASLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHN------------- 167 Query: 187 WLGHTNATVEDIYCEGPPEYKKRKIN-----SLSSKDFDCIITEFAKSQDLPYQSLSIDT 241 A + G P Y + + +LSS FD I E K DL S+ T Sbjct: 168 ----NLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFK--DLT----SLTT 217 Query: 242 FSYLNDEYVVI 252 + N+ I Sbjct: 218 LNLSNNNIANI 228 Score = 106 bits (264), Expect = 3e-23, Method: Composition-based stats. Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 11/136 (8%) Query: 52 NALCENARSIPRTVPPDVISL---SFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISD 108 N IPR V D+ SL + + I++ +L L + N+ + Sbjct: 195 NLSSNGFDEIPREVFKDLTSLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWK 254 Query: 109 DA--------FIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFK 160 A GL +L L + +N I R F+ L SL L+L+NN L +LP+ +F+ Sbjct: 255 HANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNQLTSLPQGVFE 314 Query: 161 GLDSLTNVDLRGNSFN 176 L +L ++L N Sbjct: 315 RLTNLKTLNLSNNQLQ 330 Score = 78.6 bits (192), Expect = 7e-15, Method: Composition-based stats. Identities = 24/94 (25%), Positives = 43/94 (45%), Gaps = 8/94 (8%) Query: 68 DVISLSFVRSGFTEISEGS--------FLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEY 119 ++ +L+ + + + + +L L +SN FD I + F L L Sbjct: 238 NLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTT 297 Query: 120 LFIENNNIKSISRHTFRGLKSLIHLSLANNNLQT 153 L + NN + S+ + F L +L L+L+NN LQ+ Sbjct: 298 LNLSNNQLTSLPQGVFERLTNLKTLNLSNNQLQS 331 >3J0A-A nrPDB Length = 844 Score = 128 bits (322), Expect = 6e-30, Method: Composition-based stats. Identities = 54/207 (26%), Positives = 85/207 (41%), Gaps = 31/207 (14%) Query: 67 PDVISLSFVRSGFTEIS-EGSFLFTPSLQLLLFTSNSFDVISD-----DAFIGLPHLEYL 120 P + L ++ F+ S + + PSL+ L N + + D F GL HL+ L Sbjct: 426 PHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVL 485 Query: 121 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKG------------------- 161 ++ +N + S+ F L +L LSL +N L L + Sbjct: 486 YLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDV 545 Query: 162 LDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATV----EDIYCEGPPEYKKRKINSLSSK 217 SL+ +D+ N F C+C+L + WL HTN T+ DIYC P + + SLS++ Sbjct: 546 FVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTE 605 Query: 218 DFDCIITEFAKSQDLPYQSLSIDTFSY 244 D E KS + T + Sbjct: 606 GCDE--EEVLKSLKFSLFIVCTVTLTL 630 Score = 89.3 bits (220), Expect = 3e-18, Method: Composition-based stats. Identities = 28/109 (25%), Positives = 49/109 (44%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNN 126 V L ++ F L++L N + I+D+AF GL +L+ L + N Sbjct: 266 SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNL 325 Query: 127 IKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSF 175 + + F GL + ++ L N++ + FK L+ L +DLR N+ Sbjct: 326 LGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNAL 374 Score = 77.0 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 31/114 (27%), Positives = 54/114 (47%), Gaps = 8/114 (7%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI 127 D+ L+ + +I++ +F +LQ+L + N + F GLP + Y+ ++ N+I Sbjct: 291 DLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHI 350 Query: 128 KSISRHTFRGLKSLIHLSLANNNLQT------LPKDIFKG--LDSLTNVDLRGN 173 I TF+ L+ L L L +N L T +P G L +L ++L N Sbjct: 351 AIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTAN 404 Score = 73.2 bits (178), Expect = 3e-13, Method: Composition-based stats. Identities = 32/110 (29%), Positives = 53/110 (48%), Gaps = 5/110 (4%) Query: 81 EISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKS--ISRHTFRGL 138 I + +F P+L++L S+ + DAF GL HL L + + + FR L Sbjct: 63 TIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNL 122 Query: 139 KSLIHLSLANNNLQTL-PKDIFKGLDSLTNVDLRGNS--FNCDCKLKWLV 185 K+L L L+ N +++L F L+SL ++D N C+ +L+ L Sbjct: 123 KALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQ 172 Score = 61.2 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 33/121 (27%), Positives = 51/121 (42%), Gaps = 4/121 (3%) Query: 57 NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLF-TSNSFDVISDDAFIGLP 115 N +P+ + L + ++ SF F LQLL + + I +AF LP Sbjct: 15 NLTQVPQVLNTTERLL-LSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLP 73 Query: 116 HLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQ--TLPKDIFKGLDSLTNVDLRGN 173 +L L + ++ I + F+GL L L L L L F+ L +LT +DL N Sbjct: 74 NLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKN 133 Query: 174 S 174 Sbjct: 134 Q 134 Score = 47.4 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 25/119 (21%), Positives = 45/119 (37%), Gaps = 11/119 (9%) Query: 71 SLSFVRSGFT--EISEGSFLFTPSLQLLLFTSNSFDVISDD-AFIGLPHLEYLFIENNNI 127 L G + + +G F +L L + N + +F L L+ + +N I Sbjct: 101 ELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQI 160 Query: 128 KSISRHTFRGLK--SLIHLSLANNNL---QTLPKD-IFKGLDS--LTNVDLRGNSFNCD 178 + H L+ +L SLA N+L ++ + L +D+ GN + D Sbjct: 161 FLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVD 219 Score = 28.1 bits (61), Expect = 9.4, Method: Composition-based stats. Identities = 10/40 (25%), Positives = 17/40 (42%), Gaps = 3/40 (7%) Query: 64 TVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSF 103 +P ++ L R+ + F+ SL +L T N F Sbjct: 523 DLPANLEILDISRNQLLAPNPDVFV---SLSVLDITHNKF 559 >3RG1-A nrPDB Length = 612 Score = 128 bits (322), Expect = 6e-30, Method: Composition-based stats. Identities = 38/154 (24%), Positives = 73/154 (47%), Gaps = 7/154 (4%) Query: 68 DVISLSFVRSGFT--EISEGSFLFTP-SLQLLLFTSNSFDVISDDAFIGLPHLEYLFIEN 124 D+ L+ + F IS+ + L SL++L+ +S + I AF GL ++ +L + + Sbjct: 449 DLRHLNLQGNSFQDGSISKTNLLQMVGSLEILILSSCNLLSIDQQAFHGLRNVNHLDLSH 508 Query: 125 NNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWL 184 N++ S LK L +L++A+NN++ +P + L + ++L N +C C Sbjct: 509 NSLTGDSMDALSHLKGL-YLNMASNNIRIIPPHLLPALSQQSIINLSHNPLDCTCSNIHF 567 Query: 185 VEWLG---HTNATVEDIYCEGPPEYKKRKINSLS 215 + W H E+ C PP + K++ + Sbjct: 568 ITWYKENLHKLEDSEETTCANPPSLRGVKLSDVK 601 Score = 77.0 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 53/253 (20%), Positives = 88/253 (34%), Gaps = 36/253 (14%) Query: 39 KPKCPAVCTCTKDNALCENA--RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLL 96 PKC CEN R IP T+P L F + I +F +L L Sbjct: 4 DPKCTEKE--GNRTYNCENLGLREIPDTLPNTTEVLEFSFNFLPTIQNTTFSRLINLIFL 61 Query: 97 LFTSNSFDVISDDAFI------------------------GLPHLEYLFIENNNIKSISR 132 T + + +D F G L++LF+ I ++ Sbjct: 62 DLTRCQINWVHEDTFQSHHQLNTIVLTGNPLIFMAETSLTGPKFLKHLFLTQTGISNLEF 121 Query: 133 HTFRGLKSLIHLSLANNNLQTL--PKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGH 190 L++L L L +N++ ++ P++ +L +D + N+ + + Sbjct: 122 IPVHNLENLESLHLGSNHISSINLPENF--PTQNLKVLDFQNNAIHYISRKDTNSLEQAT 179 Query: 191 T---NATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYLND 247 N DI P + + SL + F Q+ QSL + TF +D Sbjct: 180 NLSLNFNGNDIKGIEPGAFISKIFQSLKFGGSLNLFIIFKGLQNSTLQSLWLGTFEDTDD 239 Query: 248 EYVVIAQPFTGKC 260 +Y+ A F G C Sbjct: 240 QYLTSAT-FEGLC 251 Score = 52.4 bits (124), Expect = 6e-07, Method: Composition-based stats. Identities = 22/111 (19%), Positives = 41/111 (36%), Gaps = 6/111 (5%) Query: 67 PDVISLSFVRSGFTEISEGS--FLFTPSLQLLLFTSNSFDVIS--DDAFIGLPHLEYLFI 122 P + L + ++ G+ +LQ L + + + + L HL+YL + Sbjct: 324 PSLRDLYIKGN-MRKLDLGTRCLEKLENLQKLDLSHSDIEASDCCNLQLKNLRHLQYLNL 382 Query: 123 ENNNIKSISRHTFRGLKSLIHLSLANNNLQ-TLPKDIFKGLDSLTNVDLRG 172 N + F+ L L +A +L P F+ L L ++L Sbjct: 383 SYNEPLGLEDQAFKECPQLELLDVAFTHLHVKAPHSPFQNLHLLRVLNLSH 433 Score = 50.8 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 48/242 (19%), Positives = 76/242 (31%), Gaps = 65/242 (26%) Query: 60 SIPRTVP-PDVISLSFVRSGFTEISE---GSFLFTPSLQLLLFTSNSFDVISDDAFIG-- 113 ++P P ++ L F + IS S +L L F N I AFI Sbjct: 144 NLPENFPTQNLKVLDFQNNAIHYISRKDTNSLEQATNL-SLNFNGNDIKGIEPGAFISKI 202 Query: 114 -----------------------LPHL--------------------------EYLFIEN 124 L L E + ++ Sbjct: 203 FQSLKFGGSLNLFIIFKGLQNSTLQSLWLGTFEDTDDQYLTSATFEGLCDMSVESINLQK 262 Query: 125 NNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLK-- 182 + +S TFR + L L +L LP I +G++SL + L NSF+ C++ Sbjct: 263 HRFSDLSSSTFRCFTRVQELDLTAAHLNGLPSGI-EGMNSLKKLVLNANSFDQLCQINAA 321 Query: 183 ---WLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDF---DCIITEFAKSQDLPYQS 236 L + N D+ + + + LS D DC + + L Y + Sbjct: 322 SFPSLRDLYIKGNMRKLDLGTRCLEKLENLQKLDLSHSDIEASDCCNLQLKNLRHLQYLN 381 Query: 237 LS 238 LS Sbjct: 382 LS 383 Score = 39.3 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 24/109 (22%), Positives = 43/109 (39%), Gaps = 4/109 (3%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENN-N 126 V L + + G SL+ L+ +NSFD + P L L+I+ N Sbjct: 278 RVQELDLTAAHLNGLPSG-IEGMNSLKKLVLNANSFDQLCQINAASFPSLRDLYIKGNMR 336 Query: 127 IKSISRHTFRGLKSLIHLSLANNNLQTLP--KDIFKGLDSLTNVDLRGN 173 + L++L L L++++++ K L L ++L N Sbjct: 337 KLDLGTRCLEKLENLQKLDLSHSDIEASDCCNLQLKNLRHLQYLNLSYN 385 >5D3I-A nrPDB Length = 568 Score = 124 bits (312), Expect = 8e-29, Method: Composition-based stats. Identities = 39/132 (29%), Positives = 61/132 (46%), Gaps = 4/132 (3%) Query: 42 CPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSN 101 C A C + + SIP + + SL + T I G +LQ+L+ S+ Sbjct: 8 CDASGVCDGRS---RSFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSS 64 Query: 102 SFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLP-KDIFK 160 + I DAF L LE+L + +N++ S+S F L SL +L+L N QTL +F Sbjct: 65 RINTIEGDAFYSLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFP 124 Query: 161 GLDSLTNVDLRG 172 L +L + + Sbjct: 125 NLTNLQTLRIGN 136 Score = 80.9 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 3/99 (3%) Query: 78 GFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRG 137 FT I G SL + N I +L+ L ++++ I +I F Sbjct: 20 SFTSIPSGLTAAMKSL---DLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYS 76 Query: 138 LKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFN 176 L SL HL L++N+L +L F L SL ++L GN + Sbjct: 77 LGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQ 115 Score = 70.5 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 33/160 (20%), Positives = 62/160 (38%), Gaps = 13/160 (8%) Query: 66 PPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENN 125 P + L+ +G + + + L++L ++N+ D S + LP L+ L+I N Sbjct: 413 PEKMRFLNLSSTGIRVVK--TCIPQT-LEVLDVSNNNLDSFS----LFLPRLQELYISRN 465 Query: 126 NIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLV 185 +K++ + L+ + + N + T KD L ++ N F C C+L Sbjct: 466 KLKTLPDASL--FPVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHFVCSCELLSFT 523 Query: 186 E---WLGHTNATVEDIY-CEGPPEYKKRKINSLSSKDFDC 221 L D Y C+ PP ++ +C Sbjct: 524 METPALAQILVDWPDSYLCDSPPRLHGHRLQDARPSVLEC 563 Score = 45.4 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 20/113 (17%), Positives = 45/113 (39%), Gaps = 6/113 (5%) Query: 64 TVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSF--DVISDDAFIGL-PHLEYL 120 ++ V ++ S + SL+ L + N + + + A G P L+ L Sbjct: 311 SLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTL 370 Query: 121 FIENNNIKSISR--HTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLR 171 + N+++S+ + LK+L L ++ N +P + + ++L Sbjct: 371 VLSQNHLRSMQKTGEILLTLKNLTSLDISRNTFHPMPDSCQWP-EKMRFLNLS 422 Score = 42.0 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 27/167 (16%), Positives = 66/167 (39%), Gaps = 11/167 (6%) Query: 84 EGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKS--ISRHTFRGL-KS 140 + ++ + ++ ++ L LE+L + N + + +G S Sbjct: 307 STVYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPS 366 Query: 141 LIHLSLANNNLQTLPK--DIFKGLDSLTNVDLRGN---SFNCDCKLKWLVEWLGHTNATV 195 L L L+ N+L+++ K +I L +LT++D+ N C+ + +L ++ + Sbjct: 367 LQTLVLSQNHLRSMQKTGEILLTLKNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGI 426 Query: 196 EDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTF 242 + P + ++ +S+ + D + Q+L + T Sbjct: 427 RVVKTCIP---QTLEVLDVSNNNLDSFSLFLPRLQELYISRNKLKTL 470 Score = 35.0 bits (79), Expect = 0.076, Method: Composition-based stats. Identities = 20/105 (19%), Positives = 38/105 (36%), Gaps = 7/105 (6%) Query: 63 RTVPPDVISLSFVR----SGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLE 118 ++ P++ +L +R F+EI F SL L + S + + + Sbjct: 120 TSLFPNLTNLQTLRIGNVETFSEIRRIDFAGLTSLNELEIKALSLRNYQSQSLKSIRDIH 179 Query: 119 YLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLD 163 +L + + + L S+ +L L + NL F L Sbjct: 180 HLTLHLSESAFLLEIFADILSSVRYLELRDTNLARFQ---FSPLP 221 >3A7C-A nrPDB Length = 580 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 39/132 (29%), Positives = 61/132 (46%), Gaps = 4/132 (3%) Query: 42 CPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSN 101 C A C + + SIP + + SL + T I G +LQ+L+ S+ Sbjct: 30 CDASGVCDGRS---RSFTSIPSGLTAAMKSLDLSFNKITYIGHGDLRACANLQVLILKSS 86 Query: 102 SFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLP-KDIFK 160 + I DAF L LE+L + +N++ S+S F L SL +L+L N QTL +F Sbjct: 87 RINTIEGDAFYSLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFP 146 Query: 161 GLDSLTNVDLRG 172 L +L + + Sbjct: 147 NLTNLQTLRIGN 158 Score = 110 bits (275), Expect = 2e-24, Method: Composition-based stats. Identities = 34/142 (23%), Positives = 68/142 (47%), Gaps = 11/142 (7%) Query: 66 PPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENN 125 P + L+ +G + + + L++L ++N+ D S + LP L+ L+I N Sbjct: 435 PEKMRFLNLSSTGIRVVK--TCIPQT-LEVLDVSNNNLDSFS----LFLPRLQELYISRN 487 Query: 126 NIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDC-KLKWL 184 +K++ + L+ + +A+N L+++P IF L SL + L N ++C C ++ +L Sbjct: 488 KLKTLPDASL--FPVLLVMKIASNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYL 545 Query: 185 VEWLGHTNATVEDIY-CEGPPE 205 WL + + C G + Sbjct: 546 SRWLNKNSQKEQGSAKCSGSGK 567 Score = 80.5 bits (197), Expect = 2e-15, Method: Composition-based stats. Identities = 29/99 (29%), Positives = 44/99 (44%), Gaps = 3/99 (3%) Query: 78 GFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRG 137 FT I G SL + N I +L+ L ++++ I +I F Sbjct: 42 SFTSIPSGLTAAMKSL---DLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYS 98 Query: 138 LKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFN 176 L SL HL L++N+L +L F L SL ++L GN + Sbjct: 99 LGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQ 137 Score = 45.0 bits (105), Expect = 8e-05, Method: Composition-based stats. Identities = 20/113 (17%), Positives = 45/113 (39%), Gaps = 6/113 (5%) Query: 64 TVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSF--DVISDDAFIGL-PHLEYL 120 ++ V ++ S + SL+ L + N + + + A G P L+ L Sbjct: 333 SLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPSLQTL 392 Query: 121 FIENNNIKSISR--HTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLR 171 + N+++S+ + LK+L L ++ N +P + + ++L Sbjct: 393 VLSQNHLRSMQKTGEILLTLKNLTSLDISRNTFHPMPDSCQWP-EKMRFLNLS 444 Score = 41.6 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 27/167 (16%), Positives = 66/167 (39%), Gaps = 11/167 (6%) Query: 84 EGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKS--ISRHTFRGL-KS 140 + ++ + ++ ++ L LE+L + N + + +G S Sbjct: 329 STVYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSACKGAWPS 388 Query: 141 LIHLSLANNNLQTLPK--DIFKGLDSLTNVDLRGN---SFNCDCKLKWLVEWLGHTNATV 195 L L L+ N+L+++ K +I L +LT++D+ N C+ + +L ++ + Sbjct: 389 LQTLVLSQNHLRSMQKTGEILLTLKNLTSLDISRNTFHPMPDSCQWPEKMRFLNLSSTGI 448 Query: 196 EDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTF 242 + P + ++ +S+ + D + Q+L + T Sbjct: 449 RVVKTCIP---QTLEVLDVSNNNLDSFSLFLPRLQELYISRNKLKTL 492 Score = 35.0 bits (79), Expect = 0.086, Method: Composition-based stats. Identities = 20/105 (19%), Positives = 38/105 (36%), Gaps = 7/105 (6%) Query: 63 RTVPPDVISLSFVR----SGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLE 118 ++ P++ +L +R F+EI F SL L + S + + + Sbjct: 142 TSLFPNLTNLQTLRIGNVETFSEIRRIDFAGLTSLNELEIKALSLRNYQSQSLKSIRDIH 201 Query: 119 YLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLD 163 +L + + + L S+ +L L + NL F L Sbjct: 202 HLTLHLSESAFLLEIFADILSSVRYLELRDTNLARFQ---FSPLP 243 >4PBW-B nrPDB Length = 283 Score = 122 bits (307), Expect = 3e-28, Method: Composition-based stats. Identities = 42/176 (23%), Positives = 73/176 (41%), Gaps = 31/176 (17%) Query: 42 CPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSN 101 CPA C C+K + C+ PD +L + G GS S+Q+ + N Sbjct: 4 CPANCLCSKTDINCKK---------PDDGNLFPLLEGQ---DSGSSNGQTSIQITDISRN 51 Query: 102 -------------SFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLAN 148 + + + + + G L+ L I N+ +++I F L ++ L+ Sbjct: 52 ITSIHIENWKNLQTLNAVDMELYTG---LQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSG 108 Query: 149 NNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWL--GHTNATVEDIYCEG 202 N L TL +F+ L L ++ L N F C C ++W+ W G N + ++C Sbjct: 109 NRLTTLSWQLFQTL-RLFDLRLERNPFQCSCDIRWIQLWQEKGEANLQSQQLHCMN 163 >2Z7X-B nrPDB Length = 520 Score = 122 bits (306), Expect = 4e-28, Method: Composition-based stats. Identities = 39/142 (27%), Positives = 69/142 (48%), Gaps = 8/142 (5%) Query: 68 DVISLSFVRSGFTE-ISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLP-HLEYLFIENN 125 + L ++ + +G +T SL L +SN D F LP ++ L + +N Sbjct: 375 SLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILT---DTIFRCLPPRIKVLDLHSN 431 Query: 126 NIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDC-KLKWL 184 IKSI + + L++L L++A+N L+++P IF L SL + L N ++C C ++ +L Sbjct: 432 KIKSIPKQVVK-LEALQELNVASNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYL 490 Query: 185 VEWLGHTNATVEDIY-CEGPPE 205 WL + + C G + Sbjct: 491 SRWLNKNSQKEQGSAKCSGSGK 512 Score = 79.3 bits (194), Expect = 4e-15, Method: Composition-based stats. Identities = 25/117 (21%), Positives = 45/117 (38%), Gaps = 4/117 (3%) Query: 57 NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPH 116 +P+ + L+ ++ +E+ L L++L+ + N + F Sbjct: 11 GLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQE 70 Query: 117 LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLP-KDIFKGLDSLTNVDLRG 172 LEYL + +N + IS +L HL L+ N LP F + L + L Sbjct: 71 LEYLDLSHNKLVKIS---CHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLST 124 Score = 48.5 bits (114), Expect = 7e-06, Method: Composition-based stats. Identities = 30/144 (20%), Positives = 48/144 (33%), Gaps = 12/144 (8%) Query: 99 TSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDI 158 + N + D L I N I + L L L +++N +Q L + Sbjct: 8 SKNGLIHVPKDLSQKTT---ILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISV 64 Query: 159 FKGLDSLTNVDLRGNSF-NCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSK 217 FK L +DL N C + + + + P K+ ++S Sbjct: 65 FKFNQELEYLDLSHNKLVKISCHPT-----VNLKHLDLSFNAFDALPICKE--FGNMSQL 117 Query: 218 DFDCIITE-FAKSQDLPYQSLSID 240 F + T KS LP L+I Sbjct: 118 KFLGLSTTHLEKSSVLPIAHLNIS 141 Score = 32.7 bits (73), Expect = 0.49, Method: Composition-based stats. Identities = 11/48 (22%), Positives = 20/48 (41%), Gaps = 2/48 (4%) Query: 57 NARSIPRTVP--PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNS 102 +SIP+ V + L+ + + +G F SLQ + +N Sbjct: 432 KIKSIPKQVVKLEALQELNVASNQLKSVPDGIFDRLTSLQKIWLHTNP 479 >3A79-B nrPDB Length = 562 Score = 121 bits (303), Expect = 8e-28, Method: Composition-based stats. Identities = 35/145 (24%), Positives = 67/145 (46%), Gaps = 7/145 (4%) Query: 67 PDVISLSFVRSGFTEISEG-SFLFTPSLQLLLFTSNSFDVISDDAFIGLP-HLEYLFIEN 124 + +L + + + + S+ +L +SN F LP ++ L + N Sbjct: 403 SSLETLDVSLNSLNSHAYDRTCAWAESILVLNLSSNMLT---GSVFRCLPPKVKVLDLHN 459 Query: 125 NNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCK-LKW 183 N I SI + L++L L++A+N L+++P +F L SL + L N ++C C +++ Sbjct: 460 NRIMSIPKDV-THLQALQELNVASNQLKSVPDGVFDRLTSLQYIWLHDNPWDCTCPGIRY 518 Query: 184 LVEWLGHTNATVEDIYCEGPPEYKK 208 L EW+ + V + P+ K Sbjct: 519 LSEWINKHSGVVRNSAGSVAPDSAK 543 Score = 97.0 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 32/117 (27%), Positives = 54/117 (46%), Gaps = 4/117 (3%) Query: 56 ENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLP 115 N +P+ +PP +LS ++ +E+ F L++L + N + F+ Sbjct: 41 RNLTHVPKDLPPRTKALSLSQNSISELRMPDISFLSELRVLRLSHNRIRSLDFHVFLFNQ 100 Query: 116 HLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPK-DIFKGLDSLTNVDLR 171 LEYL + +N +++IS + SL HL L+ N+ LP F L LT + L Sbjct: 101 DLEYLDVSHNRLQNIS---CCPMASLRHLDLSFNDFDVLPVCKEFGNLTKLTFLGLS 154 Score = 47.4 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 38/177 (21%), Positives = 62/177 (35%), Gaps = 39/177 (22%) Query: 85 GSFLFTPSLQLLLFT----SNSFDVISDDAFIGLPHL--------EYLFIENNNIKSISR 132 GSF F +L L++ + SN + + D + L H+ + L + N+I + Sbjct: 10 GSFHFVCALALIVGSMTPFSNELESMVDYSNRNLTHVPKDLPPRTKALSLSQNSISELRM 69 Query: 133 HTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNC-DCKLKWLVEWLGHT 191 L L L L++N +++L +F L +D+ N C Sbjct: 70 PDISFLSELRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRLQNISC------------ 117 Query: 192 NATVEDIYCEGPPEYKKRKINSLSSKDFDCII--TEFAKSQDLPYQSLSIDTFSYLN 246 C + LS DFD + EF L + LS F L+ Sbjct: 118 --------CP----MASLRHLDLSFNDFDVLPVCKEFGNLTKLTFLGLSAAKFRQLD 162 >2Z80-A nrPDB Length = 353 Score = 120 bits (302), Expect = 1e-27, Method: Composition-based stats. Identities = 40/134 (29%), Positives = 62/134 (46%), Gaps = 6/134 (4%) Query: 44 AVCTCTKDNALCENA----RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFT 99 A +C N +C+ + SIP + V SL + T IS +LQ L+ T Sbjct: 26 ASLSCD-RNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLT 84 Query: 100 SNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL-PKDI 158 SN + I +D+F L LE+L + N + ++S F+ L SL L+L N +TL + Sbjct: 85 SNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSL 144 Query: 159 FKGLDSLTNVDLRG 172 F L L + + Sbjct: 145 FSHLTKLQILRVGN 158 Score = 87.4 bits (215), Expect = 2e-17, Method: Composition-based stats. Identities = 39/122 (31%), Positives = 59/122 (48%), Gaps = 5/122 (4%) Query: 60 SIPRTVPPDVISLSFVRSGFTEISEGSFLFTPS-----LQLLLFTSNSFDVISDDAFIGL 114 S+ + + SLS R+G + S GS PS ++ L ++N IS+ Sbjct: 16 SLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRC 75 Query: 115 PHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNS 174 +L+ L + +N I +I +F L SL HL L+ N L L FK L SLT ++L GN Sbjct: 76 VNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNP 135 Query: 175 FN 176 + Sbjct: 136 YK 137 Score = 76.6 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 19/74 (25%), Positives = 34/74 (45%), Gaps = 2/74 (2%) Query: 134 TFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDC-KLKWLVEWLGHTN 192 + L+ L + N L+++P IF L SL + L N ++C C ++ +L WL + Sbjct: 272 LLNQISGLLELEFSRNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLSRWLNKNS 331 Query: 193 ATVEDIY-CEGPPE 205 + C G + Sbjct: 332 QKEQGSAKCSGSGK 345 >2Z7X-A nrPDB Length = 549 Score = 119 bits (299), Expect = 3e-27, Method: Composition-based stats. Identities = 39/133 (29%), Positives = 61/133 (45%), Gaps = 6/133 (4%) Query: 45 VCTCTKDNALCENA----RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTS 100 +C N +C+ + SIP + V SL + T IS +LQ L+ TS Sbjct: 1 SLSCD-RNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTS 59 Query: 101 NSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL-PKDIF 159 N + I +D+F L LE+L + N + ++S F+ L SL L+L N +TL +F Sbjct: 60 NGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLF 119 Query: 160 KGLDSLTNVDLRG 172 L L + + Sbjct: 120 SHLTKLQILRVGN 132 Score = 98.2 bits (243), Expect = 9e-21, Method: Composition-based stats. Identities = 30/157 (19%), Positives = 65/157 (41%), Gaps = 22/157 (14%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVIS---DDAFIGL---------- 114 ++ ++ ++ F + E + + ++ L +S ++ L Sbjct: 388 NLTNIDISKNSFHSMPE-TCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLF 446 Query: 115 ----PHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDL 170 P L+ L+I N + ++ + L L+ L ++ N L+++P IF L SL + L Sbjct: 447 SLNLPQLKELYISRNKLMTLPDASL--LPMLLVLKISRNQLKSVPDGIFDRLTSLQKIWL 504 Query: 171 RGNSFNCDC-KLKWLVEWLGHTNATVEDIY-CEGPPE 205 N ++C C ++ +L WL + + C G + Sbjct: 505 HTNPWDCSCPRIDYLSRWLNKNSQKEQGSAKCSGSGK 541 Score = 84.7 bits (208), Expect = 9e-17, Method: Composition-based stats. Identities = 38/111 (34%), Positives = 55/111 (49%), Gaps = 5/111 (4%) Query: 71 SLSFVRSGFTEISEGSFLFTPS-----LQLLLFTSNSFDVISDDAFIGLPHLEYLFIENN 125 SLS R+G + S GS PS ++ L ++N IS+ +L+ L + +N Sbjct: 1 SLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSN 60 Query: 126 NIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFN 176 I +I +F L SL HL L+ N L L FK L SLT ++L GN + Sbjct: 61 GINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYK 111 Score = 40.8 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 30/132 (22%), Positives = 50/132 (37%), Gaps = 15/132 (11%) Query: 87 FLFTPSLQLLLFTSNSFDVISDDAF-------IGLPHLEYLFIENNNIKS--ISRHTFRG 137 F +L L V + F L LEYL + N + + Sbjct: 299 FYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACED 358 Query: 138 L-KSLIHLSLANNNLQTLPK--DIFKGLDSLTNVDLRGNSFNC---DCKLKWLVEWLGHT 191 SL L L N+L +L K + L +LTN+D+ NSF+ C+ +++L + Sbjct: 359 AWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLS 418 Query: 192 NATVEDIYCEGP 203 + + + P Sbjct: 419 STRIHSVTGCIP 430 Score = 30.0 bits (66), Expect = 3.1, Method: Composition-based stats. Identities = 9/39 (23%), Positives = 18/39 (46%) Query: 64 TVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNS 102 ++ P ++ L R+ + +G F SLQ + +N Sbjct: 470 SLLPMLLVLKISRNQLKSVPDGIFDRLTSLQKIWLHTNP 508 >3ULU-A nrPDB Length = 694 Score = 118 bits (295), Expect = 8e-27, Method: Composition-based stats. Identities = 47/203 (23%), Positives = 75/203 (36%), Gaps = 42/203 (20%) Query: 56 ENARSIPRTVPP--DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDA--- 110 +N S P P ++ L + I++ L++L N+ + A Sbjct: 477 KNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPG 536 Query: 111 -----FIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIF------ 159 GL HL L +E+N I F+ L L + L NNL TLP +F Sbjct: 537 GPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSL 596 Query: 160 -------------------KGLDSLTNVDLRGNSFNCDCK-LKWLVEWLGHTNATVEDI- 198 +LT +D+R N F+C C+ + W V W+ T+ + ++ Sbjct: 597 KSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELS 656 Query: 199 ---YCEGPPEYKK--RKINSLSS 216 C PP Y ++ SS Sbjct: 657 SHYLCNTPPHYHGFPVRLFDTSS 679 Score = 114 bits (286), Expect = 8e-26, Method: Composition-based stats. Identities = 59/237 (24%), Positives = 93/237 (39%), Gaps = 52/237 (21%) Query: 68 DVISLSFVRSGFTEISEGSFLFTP--SLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENN 125 + +LS S + S +FL +L +L + N+ +V+ +D+F LP LEY F+E N Sbjct: 233 SIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYN 292 Query: 126 NIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLV 185 NI+ + H+ GL ++ +L+L K F ++ L D +WL Sbjct: 293 NIQHLFSHSLHGLFNVRYLNL---------KRSFTK----QSISLASLPKIDDFSFQWL- 338 Query: 186 EWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDL-----------PY 234 + L H N DI P K L + + + F + L P Sbjct: 339 KCLEHLNMEDNDI-----PGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPL 393 Query: 235 QSLSI----------DTFSYLNDEYVV------IAQPFTGKCIFLEWDHVEKTFRNY 275 L++ D FS+L V+ I Q TG+ EW +E F Y Sbjct: 394 HILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQ----EWRGLENIFEIY 446 Score = 100 bits (250), Expect = 1e-21, Method: Composition-based stats. Identities = 29/135 (21%), Positives = 57/135 (42%), Gaps = 2/135 (1%) Query: 46 CTCTKDNALCE--NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSF 103 CT + + A C +P +P ++ L+ + + +F L L N+ Sbjct: 12 CTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTI 71 Query: 104 DVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLD 163 + + LP L+ L +++N + +S TF +L L L +N++Q + + F Sbjct: 72 SKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQK 131 Query: 164 SLTNVDLRGNSFNCD 178 +L +DL N + Sbjct: 132 NLITLDLSHNGLSST 146 Score = 77.4 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 44/204 (21%), Positives = 85/204 (41%), Gaps = 21/204 (10%) Query: 69 VISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSF-DVISDDAFIGLPHLEYLFIENNNI 127 + L+ ++ ++I +F + L++L N ++ + GL ++ +++ N Sbjct: 393 LHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKY 452 Query: 128 KSISRHTFRGLKSLIHLSLANNNLQTL--PKDIFKGLDSLTNVDLRGNSFNCDC--KLKW 183 ++R++F + SL L L L+ + F+ L +LT +DL N+ L+ Sbjct: 453 LQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEG 512 Query: 184 LVEW----LGHTN-ATVEDIYCEGPPEYKKRKIN-----SLSSKDFDCIITEFA------ 227 L + L H N A + G P Y + ++ +L S FD I E Sbjct: 513 LEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFEL 572 Query: 228 KSQDLPYQSLSIDTFSYLNDEYVV 251 K DL +L+ S N++ + Sbjct: 573 KIIDLGLNNLNTLPASVFNNQVSL 596 Score = 70.5 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 38/187 (20%), Positives = 73/187 (39%), Gaps = 12/187 (6%) Query: 64 TVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIE 123 + S + +I + SF + L+ L N I + F GL +L+YL + Sbjct: 312 NLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLS 371 Query: 124 N--NNIKSISRHTFRGLKS--LIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCD- 178 N ++++++ TF L L L+L N + + D F L L +DL N + Sbjct: 372 NSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQEL 431 Query: 179 --CKLKWLVE----WLGHTN-ATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQD 231 + + L +L + + P ++ + ++ K+ D + F ++ Sbjct: 432 TGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRN 491 Query: 232 LPYQSLS 238 L LS Sbjct: 492 LTILDLS 498 >4R08-A nrPDB Length = 811 Score = 117 bits (293), Expect = 1e-26, Method: Composition-based stats. Identities = 43/188 (22%), Positives = 73/188 (38%), Gaps = 10/188 (5%) Query: 49 TKDNALCENARSIPR----TVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD 104 T+ + + IP +P + L + + P L+LL N Sbjct: 620 TRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLL 679 Query: 105 VISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFK--GL 162 ++D L L + +N I + + SL HL L++N L+T+ K + Sbjct: 680 FLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTT 739 Query: 163 DSLTNVDLRGNSFNCDCKLKWLVEWL-GHTNATVE---DIYCEGPPEYKKRKINSLSSKD 218 L+ ++L GN F C C + W+ H N + D+ C P + + + I SL Sbjct: 740 TKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTT 799 Query: 219 FDCIITEF 226 +TEF Sbjct: 800 CVSDVTEF 807 Score = 81.2 bits (199), Expect = 1e-15, Method: Composition-based stats. Identities = 32/134 (23%), Positives = 49/134 (36%), Gaps = 21/134 (15%) Query: 60 SIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSN------------------ 101 +P +P + L + ISE F +L LL + N Sbjct: 193 HVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGA 252 Query: 102 SFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQ-TLPKDIFK 160 S + I AF L L YL + + +++ I+ F+ + L L L N L + F Sbjct: 253 SIN-IDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFL 311 Query: 161 G-LDSLTNVDLRGN 173 L L +DL N Sbjct: 312 TMLPRLEILDLSFN 325 Score = 75.9 bits (185), Expect = 5e-14, Method: Composition-based stats. Identities = 37/141 (26%), Positives = 57/141 (40%), Gaps = 19/141 (13%) Query: 49 TKDNALCENA--RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSN----- 101 A C N + +P+TV V L + T I+ SF +L + N Sbjct: 21 DSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQH 80 Query: 102 ---------SFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQ 152 + I+D AF+ L +L L +E+N + I +SL LSL NN+ Sbjct: 81 QNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGL---PESLTELSLIQNNIY 137 Query: 153 TLPKDIFKGLDSLTNVDLRGN 173 + K+ L +L N+ L N Sbjct: 138 NITKEGISRLINLKNLYLAWN 158 Score = 65.5 bits (158), Expect = 6e-11, Method: Composition-based stats. Identities = 38/188 (20%), Positives = 72/188 (38%), Gaps = 21/188 (11%) Query: 67 PDVISLSFVRS-GFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENN 125 PD+ L+ + +S F P ++ L T+N D + A L LE L + N Sbjct: 483 PDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYN 542 Query: 126 ----NIKSISRHT--FRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFN--- 176 I ++ H + +L L+L++NN+ TL SL + GN + Sbjct: 543 SHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILW 602 Query: 177 CDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQS 236 D +++ + G N T D+ ++ + ++ F + A +L Sbjct: 603 NDDDNRYISIFKGLKNLTRLDLSLN--------RLKHIPNEAFLNLP---ASLTELHIND 651 Query: 237 LSIDTFSY 244 + F++ Sbjct: 652 NMLKFFNW 659 Score = 65.1 bits (157), Expect = 9e-11, Method: Composition-based stats. Identities = 33/196 (16%), Positives = 78/196 (39%), Gaps = 20/196 (10%) Query: 70 ISLSFVRSGFTEISEGSFLFTPSLQLLLFTSN-SFDVISDDAFIGLPHLEYLFIENNNIK 128 +L + I F P + L ++N + V+S F +PH++YL + NN + Sbjct: 462 KALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLD 521 Query: 129 SISRHTFRGLKSLIHLSLANN----NLQTLPKDI--FKGLDSLTNVDLRGNSFNCDCKLK 182 + L L L L+ N + + + + +L ++L N + Sbjct: 522 FDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHN------NIY 575 Query: 183 WLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTF 242 L + + ++ ++ + +++ L + D + I+ F ++L LS++ Sbjct: 576 TLTDKYNLESKSLVELV------FSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRL 629 Query: 243 SYL-NDEYVVIAQPFT 257 ++ N+ ++ + T Sbjct: 630 KHIPNEAFLNLPASLT 645 Score = 60.8 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 33/183 (18%), Positives = 59/183 (32%), Gaps = 69/183 (37%) Query: 60 SIPRTVPPDVISLSFVRSGF-------------------------------TEISEGSFL 88 IP +P + LS +++ T I +G F Sbjct: 117 QIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFE 176 Query: 89 FTPS---------------------LQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI 127 + L+ L ++ IS++ F GL +L L + N Sbjct: 177 TLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCP 236 Query: 128 K-----------------SISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDL 170 + +I R F+ L L +L+L++ +L+ + FK + L +DL Sbjct: 237 RCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDL 296 Query: 171 RGN 173 N Sbjct: 297 EFN 299 Score = 58.1 bits (139), Expect = 9e-09, Method: Composition-based stats. Identities = 25/120 (20%), Positives = 47/120 (39%), Gaps = 13/120 (10%) Query: 67 PDVISLSFVRSGFT-EISEGSF-LFTPSLQLLLFTSNSFD-------VISDDAFIGLPHL 117 P + L + EI+ G+F P L++L + N IS + F L L Sbjct: 289 PHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRN-FSKLLSL 347 Query: 118 EYLFIENNNIKSISRHTFRGL---KSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNS 174 L + + + F+ L +L ++L N ++ + +F+ +L + L N Sbjct: 348 RALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENR 407 Score = 44.7 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 24/149 (16%), Positives = 46/149 (30%), Gaps = 42/149 (28%) Query: 68 DVISLSFVRSGFTEISEGSFLFT---PSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIEN 124 + +L F E+ E F P+L + N I F +LE +++ Sbjct: 346 SLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSE 405 Query: 125 NNIKSISRHT------------------------------FRGLKSL---------IHLS 145 N I + + T + + L L Sbjct: 406 NRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALD 465 Query: 146 LANNNLQTLPKDIFKGLDSLTNVDLRGNS 174 L+ N++ + + F+ L + ++L NS Sbjct: 466 LSLNSIFFIGPNQFENLPDIACLNLSANS 494 Score = 42.0 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 25/102 (24%), Positives = 38/102 (37%), Gaps = 11/102 (10%) Query: 67 PDVISLSFVRSGFT-------EISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGL---PH 116 P + L + IS F SL+ L F + +D F L P+ Sbjct: 315 PRLEILDLSFNYIKGSYPQHINISRN-FSKLLSLRALHLRGYVFQELREDDFQPLMQLPN 373 Query: 117 LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDI 158 L + + N IK I F+ +L + L+ N + L KD Sbjct: 374 LSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDT 415 >3CIG-A nrPDB Length = 697 Score = 117 bits (292), Expect = 2e-26, Method: Composition-based stats. Identities = 40/180 (22%), Positives = 70/180 (38%), Gaps = 38/180 (21%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDA--------FIGLPHLE 118 ++ L + I+E +L++L F N+ + A GL HL Sbjct: 480 RNLTILDLSNNNIANINEDLLEGLENLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLH 539 Query: 119 YLFIENNNIKSISRHTFRGL------------------------KSLIHLSLANNNLQTL 154 L +E+N + I F+ L SL L+L N + ++ Sbjct: 540 ILNLESNGLDEIPVGVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLITSV 599 Query: 155 PKDIF-KGLDSLTNVDLRGNSFNCDCK-LKWLVEWLGHTNATVEDI----YCEGPPEYKK 208 KD+F +L ++D+R N F+C C+ + W V W+ T+ + ++ C P Y Sbjct: 600 EKDVFGPPFQNLNSLDMRFNPFDCTCESISWFVNWINQTHTNISELSTHYLCNTPHHYYG 659 Score = 99.4 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 56/237 (23%), Positives = 90/237 (37%), Gaps = 52/237 (21%) Query: 68 DVISLSFVRSGFTEISEGSFLFTP--SLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENN 125 + +LS + SE +F +L L + N+ + + +F LP L YL +E N Sbjct: 223 SIQNLSLANNQLLATSESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYN 282 Query: 126 NIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLV 185 NI+ +S +F GL +L +LSL K F +V L + D +WL Sbjct: 283 NIQRLSPRSFYGLSNLRYLSL---------KRAFTK----QSVSLASHPNIDDFSFQWL- 328 Query: 186 EWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDL-----------PY 234 ++L + N +I P K L S + + F Q L P Sbjct: 329 KYLEYLNMDDNNI-----PSTKSNTFTGLVSLKYLSLSKTFTSLQTLTNETFVSLAHSPL 383 Query: 235 QSLSID----------TFSYLNDEYVV------IAQPFTGKCIFLEWDHVEKTFRNY 275 +L++ TFS+L ++ I Q +G+ EW + F Y Sbjct: 384 LTLNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKLSGQ----EWRGLRNIFEIY 436 Score = 98.2 bits (243), Expect = 9e-21, Method: Composition-based stats. Identities = 32/135 (23%), Positives = 57/135 (42%), Gaps = 2/135 (1%) Query: 46 CTCTKDNALCE--NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSF 103 CT + A C IP +P ++ L+ + + +F L +L NS Sbjct: 2 CTVRYNVADCSHLKLTHIPDDLPSNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSI 61 Query: 104 DVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLD 163 + + LP L+ L +++N + IS TF +L L L +N++ + + FK Sbjct: 62 SKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQK 121 Query: 164 SLTNVDLRGNSFNCD 178 +L +DL N + Sbjct: 122 NLIKLDLSHNGLSST 136 Score = 73.9 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 38/173 (21%), Positives = 69/173 (39%), Gaps = 15/173 (8%) Query: 71 SLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSF-DVISDDAFIGLPHLEYLFIENNNIKS 129 +L+ ++ ++I+ G+F + L++L N +S + GL ++ +++ N Sbjct: 385 TLNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKYLQ 444 Query: 130 ISRHTFRGLKSLIHLSLANNNLQ--TLPKDIFKGLDSLTNVDLRGNSF--NCDCKLKWLV 185 +S +F + SL L L L+ + F+ L +LT +DL N+ + L+ L Sbjct: 445 LSTSSFALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDLLEGLE 504 Query: 186 EW----LGHTN-ATVEDIYCEGPPE-----YKKRKINSLSSKDFDCIITEFAK 228 H N A + G P I +L S D I K Sbjct: 505 NLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLESNGLDEIPVGVFK 557 Score = 68.5 bits (166), Expect = 8e-12, Method: Composition-based stats. Identities = 36/199 (18%), Positives = 78/199 (39%), Gaps = 12/199 (6%) Query: 64 TVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIE 123 ++ S + I + SF + L+ L N+ + F GL L+YL + Sbjct: 302 SLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSLS 361 Query: 124 N--NNIKSISRHTFRGLKS--LIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFN--- 176 ++++++ TF L L+ L+L N++ + F L L +DL N Sbjct: 362 KTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKL 421 Query: 177 CDCKLKWLVE----WLGHTN-ATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQD 231 + + L +L + + P ++ + ++ K+ D + F ++ Sbjct: 422 SGQEWRGLRNIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVALKNVDISPSPFRPLRN 481 Query: 232 LPYQSLSIDTFSYLNDEYV 250 L LS + + +N++ + Sbjct: 482 LTILDLSNNNIANINEDLL 500 >4QDH-A nrPDB Length = 438 Score = 116 bits (291), Expect = 2e-26, Method: Composition-based stats. Identities = 36/142 (25%), Positives = 60/142 (42%), Gaps = 3/142 (2%) Query: 36 KPAKPKCPAVCTCTKDNALC--ENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSL 93 P CP+ C+C+ C + S+P +P L + + G F L Sbjct: 2 DPGGKACPSRCSCSGTEIRCNSKGLTSVPTGIPSSATRLELESNKLQSLPHGVFDKLTQL 61 Query: 94 QLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI-KSISRHTFRGLKSLIHLSLANNNLQ 152 L + N+ I + F+ L L+ L + +N+I ++++ F L +L L L++N L Sbjct: 62 TKLSLSRNNLVTIKPEMFVNLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLD 121 Query: 153 TLPKDIFKGLDSLTNVDLRGNS 174 F L L +DL NS Sbjct: 122 LYHWKSFSELPQLQALDLSYNS 143 Score = 108 bits (270), Expect = 7e-24, Method: Composition-based stats. Identities = 34/156 (21%), Positives = 65/156 (41%), Gaps = 27/156 (17%) Query: 77 SGFTEISEGSFLFTPSLQLLLFTSNSFDVISDD-----------------------AFIG 113 + + + S F P+L++L N +++ AF Sbjct: 250 NYLSFFNWTSLSFLPNLEVLDLAGNQLKALTNGTLPNGTLLQKLDVSSNSIVSVVPAFFA 309 Query: 114 LP-HLEYLFIENNNIKSISRHTFRG-LKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLR 171 L L+ + + +N +K++ R F + +L L+L N L+++P IF L SL + L Sbjct: 310 LAVELKEVNLSHNILKTVDRSWFGPIVMNLKELALDTNQLKSVPDGIFDRLTSLQKIWLH 369 Query: 172 GNSFNCDC-KLKWLVEWLGHTNATVEDIY-CEGPPE 205 N ++C C ++ +L WL + + C G + Sbjct: 370 TNPWDCSCPRIDYLSRWLNKNSQKEQGSAKCSGSGK 405 >4PBV-A nrPDB Length = 268 Score = 115 bits (289), Expect = 4e-26, Method: Composition-based stats. Identities = 41/165 (24%), Positives = 70/165 (42%), Gaps = 24/165 (14%) Query: 42 CPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTE--ISEGSFLFTPSLQLLLFT 99 CPA C C+K + C+ PD +L + G I+ +LQ L Sbjct: 4 CPANCLCSKTDINCKK---------PDDGNLFPLLEGQDSRNITSIHIENWKNLQTL--- 51 Query: 100 SNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIF 159 + + + + G L+ L I N+ +++I F L ++ L+ N L TL +F Sbjct: 52 ----NAVDMELYTG---LQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLSWQLF 104 Query: 160 KGLDSLTNVDLRGNSFNCDCKLKWLVEWL--GHTNATVEDIYCEG 202 + L L ++ L N F C C ++W+ W G N + ++C Sbjct: 105 QTL-RLFDLRLERNPFQCSCDIRWIQLWQEKGEANLQSQQLHCMN 148 >3B2D-A nrPDB Length = 603 Score = 115 bits (287), Expect = 7e-26, Method: Composition-based stats. Identities = 32/155 (20%), Positives = 64/155 (41%), Gaps = 7/155 (4%) Query: 67 PDVISLSFVRSGF---TEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIE 123 P + L+ + F T SL++L+ +S I AF L + ++ + Sbjct: 446 PVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLS 505 Query: 124 NNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKW 183 +N++ S + LK + +L+LA N++ + + L + ++L N +C C Sbjct: 506 HNSLTCDSIDSLSHLKGI-YLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIH 564 Query: 184 LVEWLG---HTNATVEDIYCEGPPEYKKRKINSLS 215 + W H E+ C PP + K++ + Sbjct: 565 FLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVK 599 Score = 74.3 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 32/127 (25%), Positives = 48/127 (37%), Gaps = 2/127 (1%) Query: 49 TKDNALCENA--RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVI 106 CEN IP T+P L F + I +F +L L T + I Sbjct: 10 ANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWI 69 Query: 107 SDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLT 166 +D F L L + N + ++ + G KSL HL L + L L++L Sbjct: 70 HEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLE 129 Query: 167 NVDLRGN 173 ++ L N Sbjct: 130 SLYLGSN 136 Score = 55.8 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 31/123 (25%), Positives = 49/123 (39%), Gaps = 6/123 (4%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI 127 V SL+ F++IS +F LQ L T+ + GL L+ L + N+ Sbjct: 252 SVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGM-KGLNLLKKLVLSVNHF 310 Query: 128 KSISRHTFRGLKSLIHLSLANNNLQT-LPKDIFKGLDSLTNVDLRGNSFN----CDCKLK 182 + + + SL HL + N + L + L +L +DL N C +LK Sbjct: 311 DQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLK 370 Query: 183 WLV 185 L Sbjct: 371 NLS 373 >3V44-A nrPDB Length = 407 Score = 111 bits (278), Expect = 7e-25, Method: Composition-based stats. Identities = 34/137 (24%), Positives = 57/137 (41%), Gaps = 4/137 (2%) Query: 73 SFVRSGFTEISEGSFLFT--PSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSI 130 SF + F + +F ++ + + + F LE L + N I I Sbjct: 255 SFGHTNFKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKI 314 Query: 131 SRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDC-KLKWLVEWLG 189 + F GL L L+L N L+++P IF L SL + L N ++C C ++ +L WL Sbjct: 315 DDNAFWGLTHLKELALDTNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLSRWLN 374 Query: 190 HTNATVEDIY-CEGPPE 205 + + C G + Sbjct: 375 KNSQKEQGSAKCSGSGK 391 Score = 78.6 bits (192), Expect = 8e-15, Method: Composition-based stats. Identities = 47/233 (20%), Positives = 84/233 (36%), Gaps = 47/233 (20%) Query: 45 VCTCTKDNALC--ENARSIPRTVPPDVISLSFVRSGFTE--------------------- 81 C+ NA+C +P +P V + + E Sbjct: 7 ECSVIGYNAICINRGLHQVP-ELPAHVNYVDLSLNSIAELNETSFSRLQDLQFLKVEQQT 65 Query: 82 ----ISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKS--ISRHTF 135 I +F SL +L N F + AF GL +LE L + N+ +S + F Sbjct: 66 PGLVIRNNTFRGLSSLIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFF 125 Query: 136 RGLKSLIHLSLANNNLQTL-PKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNAT 194 + L SL L L +NN++ + P F + +DL N C+ Sbjct: 126 KPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLTFNKVKSICE-------------- 171 Query: 195 VEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYLND 247 ED+ + +++S++ +D + + K + P+++ SI T + Sbjct: 172 -EDLLNFQGKHFTLLRLSSITLQDMNEYWLGWEKCGN-PFKNTSITTLDLSGN 222 Score = 59.7 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 45/238 (18%), Positives = 79/238 (33%), Gaps = 57/238 (23%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD--VISDDAFIGLPHLEYLFIEN 124 +I L + F ++ G+F +L++L T + D V+S + F L LE L + + Sbjct: 79 SSLIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRD 138 Query: 125 NNIKSI-SRHTFRGLKSLIHLSLANNNLQTL------------------PKDIFKGL--- 162 NNIK I F ++ L L N ++++ + + Sbjct: 139 NNIKKIQPASFFLNMRRFHVLDLTFNKVKSICEEDLLNFQGKHFTLLRLSSITLQDMNEY 198 Query: 163 -------------DSLTNVDLRGNSFNCDCKLKWLV-------------------EWLGH 190 S+T +DL GN F ++ GH Sbjct: 199 WLGWEKCGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAGTKIQSLILSNSYNMGSSFGH 258 Query: 191 TNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAK-SQDLPYQSLSIDTFSYLND 247 TN D + E K LS ++ DL +L+ + + ++D Sbjct: 259 TNFKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDD 316 >6GFF-I nrPDB Length = 618 Score = 106 bits (265), Expect = 2e-23, Method: Composition-based stats. Identities = 39/186 (20%), Positives = 63/186 (33%), Gaps = 54/186 (29%) Query: 46 CTCTKDNALCE--NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSF 103 C C+ +P +PPD +L + I F +L+ L ++N Sbjct: 7 CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 66 Query: 104 DVISDDAFIGLPHLEYLFIENNNI------------------------------------ 127 + AF L HLE+L + +N + Sbjct: 67 SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLL 126 Query: 128 ----------------KSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLR 171 ++RHTFR + +L L L +N L + F+GL LT+++L Sbjct: 127 GEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLS 186 Query: 172 GNSFNC 177 NS C Sbjct: 187 RNSLTC 192 Score = 78.9 bits (193), Expect = 5e-15, Method: Composition-based stats. Identities = 28/108 (25%), Positives = 44/108 (40%), Gaps = 1/108 (0%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNN 126 +++L + I + SL L + N LP L L + +N Sbjct: 296 SQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNA 355 Query: 127 IKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNS 174 ++++ R L SL L L N L+ LP F L SL ++L+GN Sbjct: 356 LETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNR 402 Score = 73.5 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 38/159 (23%), Positives = 64/159 (40%), Gaps = 14/159 (8%) Query: 69 VISLSFVRSGFTEISEGSFLFT-PSLQLLLFTSNSFDVISDDA--FIGLPHLEYLFIENN 125 + L + E++ G+ SL++L N V+ D FI L+ L + N Sbjct: 449 LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFIC---LKRLNLAEN 505 Query: 126 NIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGL-DSLTNVDLRGNSFNCDCKLKWL 184 + + + SL L L NN+ LP GL SL + L+GN +C C WL Sbjct: 506 RLSHLP--AWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSC-CGNGWL 562 Query: 185 VEWLGHTNATV---EDIYCEGPPEYKKRKINSLSSKDFD 220 L V +D+ C ++ ++ + +D + Sbjct: 563 AAQLHQGRVDVDATQDLICRFS-SQEEVSLSHVRPEDCE 600 Score = 70.1 bits (170), Expect = 3e-12, Method: Composition-based stats. Identities = 30/125 (24%), Positives = 49/125 (39%), Gaps = 13/125 (10%) Query: 61 IPRTVPPDVISL---SFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHL 117 IP + + SL + R+ P L LL + N+ + + A L L Sbjct: 311 IPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-RALGSL 369 Query: 118 EYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL-------PKD--IFKGLDSLTNV 168 L ++ N ++ + +TF L SL L+L N + P F G+ SL ++ Sbjct: 370 RTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSL 429 Query: 169 DLRGN 173 L N Sbjct: 430 SLVDN 434 Score = 65.5 bits (158), Expect = 6e-11, Method: Composition-based stats. Identities = 29/130 (22%), Positives = 48/130 (36%), Gaps = 44/130 (33%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNN 126 P + +LS + T ++ +F P+L+ L SN I D AF GLP L +L + N+ Sbjct: 130 PSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNS 189 Query: 127 IKSISRHTFR--------------------------------------------GLKSLI 142 + IS + + L LI Sbjct: 190 LTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLI 249 Query: 143 HLSLANNNLQ 152 +L+L+NN ++ Sbjct: 250 YLNLSNNLIR 259 Score = 64.3 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 28/125 (22%), Positives = 50/125 (40%), Gaps = 7/125 (5%) Query: 57 NARSIPRTVPPDVISLSFVRSGFTEISEGSF------LFTPSLQLLLFTSNSFDVISDDA 110 N +P P D + G++ + + L L + N ++I D Sbjct: 256 NLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSF 315 Query: 111 FIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDL 170 L L +L + N +++ L L+ L L++N L+TL + L SL + L Sbjct: 316 LEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLL 374 Query: 171 RGNSF 175 +GN+ Sbjct: 375 QGNAL 379 Score = 63.5 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 35/176 (19%), Positives = 59/176 (33%), Gaps = 28/176 (15%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD--VISDD-------AFIGLPHLE 118 + +L + ++ +F SLQ L N D+ AF G+ L Sbjct: 368 SLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLR 427 Query: 119 YLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLD-SLTNVDLRGNS--- 174 L + +N I+ + F L L L++N + GL+ SL + L+GN Sbjct: 428 SLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMV 486 Query: 175 -------FNC-------DCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSS 216 F C + +L L W + V D+ + L + Sbjct: 487 LQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLET 542 Score = 59.3 bits (142), Expect = 5e-09, Method: Composition-based stats. Identities = 26/134 (19%), Positives = 38/134 (28%), Gaps = 28/134 (20%) Query: 69 VISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSF--------------------DVISD 108 + L + P L L ++N + Sbjct: 226 LTWLDLRENKLLHFP--DLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPL 283 Query: 109 DAFIG------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGL 162 A G L L L + N I+ I L SL L+L+ N L+T L Sbjct: 284 SAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSL 343 Query: 163 DSLTNVDLRGNSFN 176 L +DL N+ Sbjct: 344 PCLMLLDLSHNALE 357 >4AY9-X nrPDB Length = 350 Score = 100 bits (250), Expect = 1e-21, Method: Composition-based stats. Identities = 41/218 (18%), Positives = 82/218 (37%), Gaps = 48/218 (22%) Query: 45 VCTCTKDNALCENAR--SIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSN- 101 +C C+ LC+ ++ IP +P + I L FV + I +G+F L+ + + N Sbjct: 6 ICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQND 65 Query: 102 -------------------------SFDVISDDAFIGLPHLEYLFIENNNIKSISR-HTF 135 + I+ +AF LP+L+YL I N IK + H Sbjct: 66 VLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKI 125 Query: 136 RGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATV 195 L+ ++ N N+ T+ ++ F GL + ++ WL + Sbjct: 126 HSLQKVLLDIQDNINIHTIERNSFVGLS-----------------FESVILWLNKNG--I 166 Query: 196 EDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLP 233 ++I+ + ++N + + + + + P Sbjct: 167 QEIHNSAFNGTQLDELNLSDNNNLEELPNDVFHGASGP 204 Score = 54.3 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 23/101 (22%), Positives = 40/101 (39%), Gaps = 7/101 (6%) Query: 71 SLSFVRS-GFTEISEGSFLFTP-SLQLLLFTSNSFDVISDDAFIGLPHLEYLFIE-NNNI 127 L + I SF+ +L N I + AF G L+ L + NNN+ Sbjct: 132 LLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNSAFNG-TQLDELNLSDNNNL 190 Query: 128 KSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNV 168 + + F G + L ++ + +LP GL++L + Sbjct: 191 EELPNDVFHGASGPVILDISRTRIHSLPS---YGLENLKKL 228 Score = 52.0 bits (123), Expect = 8e-07, Method: Composition-based stats. Identities = 35/170 (20%), Positives = 59/170 (34%), Gaps = 9/170 (5%) Query: 72 LSFVRSGFTEISEGSFLFTPSLQLLLFT-SNSFDVISDDAFIGLPHLEYLFIENNNIKSI 130 L ++G EI +F L L + +N+ + + +D F G L I I S+ Sbjct: 159 LWLNKNGIQEIHNSAFNG-TQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSL 217 Query: 131 SRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGH 190 + LK L S N L+ LP + L +L L +C C + Sbjct: 218 PSYGLENLKKLRARSTYN--LKKLP--TLEKLVALMEASLTY-PSHC-CAFANWRRQISE 271 Query: 191 TNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID 240 + +Y + SS D + +++ D+ Y D Sbjct: 272 LHPICNKSILRQEVDYMTQARGQRSSLAEDN-ESSYSRGFDMTYTEFDYD 320 >5Y3K-A nrPDB Length = 802 Score = 100 bits (249), Expect = 2e-21, Method: Composition-based stats. Identities = 35/154 (22%), Positives = 60/154 (38%), Gaps = 6/154 (3%) Query: 64 TVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIE 123 +P + L + + S P+L+ L N +S+ + L+ L + Sbjct: 629 NLPKSLQLLRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLDVS 688 Query: 124 NNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLD-SLTNVDLRGNSFNCDCKLK 182 N+I + F L L+L+ N L+T+ F L SL +D+ N +C C Sbjct: 689 RNSIIFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEVLDVSANPLHCACGAA 748 Query: 183 WLVEWLGHTNATVEDI----YCEGPPEYKKRKIN 212 V++L A V + C P + + R I Sbjct: 749 -FVDFLLQVQAAVPGLPSRVKCGSPGQLQGRSIF 781 Score = 76.2 bits (186), Expect = 3e-14, Method: Composition-based stats. Identities = 31/135 (22%), Positives = 56/135 (41%), Gaps = 18/135 (13%) Query: 57 NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSN--------------- 101 N ++PR++PP + L + ++ +L++L N Sbjct: 189 NLTTVPRSLPPSLEYLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCVECP 248 Query: 102 -SFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQ--TLPKDI 158 F + D F L LE L ++++++ ++ FRGL +L L L+ N L Sbjct: 249 HKFPQLHSDTFSHLSRLEGLVLKDSSLYQLNPRWFRGLGNLTVLDLSENFLYDCITKTKA 308 Query: 159 FKGLDSLTNVDLRGN 173 F+GL L ++L N Sbjct: 309 FQGLAQLRRLNLSFN 323 Score = 70.8 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 32/135 (23%), Positives = 61/135 (45%), Gaps = 12/135 (8%) Query: 52 NALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDV------ 105 N ++P +P ++SL R+ ++ S +L+ L N + Sbjct: 108 NLSYNGITTVPA-LPSSLVSLILSRTNILQLDPTSLTGLHALRFLYMDGNCYYKNPCGRA 166 Query: 106 --ISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLD 163 ++ A +GL +L +L ++ NN+ ++ R SL +L L+ N++ TL + L Sbjct: 167 LEVAPGALLGLGNLTHLSLKYNNLTTVPRSL---PPSLEYLLLSYNHIVTLAPEDLANLT 223 Query: 164 SLTNVDLRGNSFNCD 178 +L +D+ GN CD Sbjct: 224 ALRVLDVGGNCRRCD 238 Score = 68.9 bits (167), Expect = 5e-12, Method: Composition-based stats. Identities = 34/146 (23%), Positives = 53/146 (36%), Gaps = 36/146 (24%) Query: 67 PDVISLSFVRSGFTEISEGS-FLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENN 125 + L + ++ GS F+ SLQ+L + N D+ +F LP LE L + N Sbjct: 475 SRLQCLRLSHNSISQAVNGSQFVPLTSLQVLDLSHNKLDLYHGRSFTELPRLEALDLSYN 534 Query: 126 NIKSISRHTFRG------LKSLIHLSLANNNLQT-------------------------- 153 + R L +L +LSLA+N + + Sbjct: 535 SQPFSMRGVGHNLSFVAQLPTLRYLSLAHNGIHSRVSQQLCSTSLWALDFSGNSLSQMWA 594 Query: 154 ---LPKDIFKGLDSLTNVDLRGNSFN 176 L F+GL SL +DL N + Sbjct: 595 EGDLYLRFFQGLRSLIRLDLSQNRLH 620 Score = 67.0 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 31/117 (26%), Positives = 43/117 (36%), Gaps = 8/117 (6%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDA------FIGLPHLEYL 120 P + LS +G + SL L F+ NS + + F GL L L Sbjct: 554 PTLRYLSLAHNGIHSRVSQQLC-STSLWALDFSGNSLSQMWAEGDLYLRFFQGLRSLIRL 612 Query: 121 FIENNNIKSISRHTFRGLK-SLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFN 176 + N + ++ T L SL L L NN L L +L +DL GN Sbjct: 613 DLSQNRLHTLLPCTLGNLPKSLQLLRLRNNYLAFFNWSSLTLLPNLETLDLAGNQLK 669 Score = 64.3 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 28/115 (24%), Positives = 48/115 (41%), Gaps = 15/115 (13%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENN- 125 P + L+ +G T + SL L+ + + + + GL L +L+++ N Sbjct: 102 PTLEELNLSYNGITTVPA----LPSSLVSLILSRTNILQLDPTSLTGLHALRFLYMDGNC 157 Query: 126 -------NIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173 ++ GL +L HLSL NNL T+P+ + SL + L N Sbjct: 158 YYKNPCGRALEVAPGALLGLGNLTHLSLKYNNLTTVPRSLPP---SLEYLLLSYN 209 Score = 63.1 bits (152), Expect = 3e-10, Method: Composition-based stats. Identities = 28/118 (23%), Positives = 46/118 (38%), Gaps = 16/118 (13%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSN----SFD--------VISDDAFIGLP 115 +V SLS + + + + F +LQ L N I + F+ +P Sbjct: 43 NVTSLSLLSNRIHHLHDSDFAQLSNLQKLNLKWNCPPAGLSPMHFPCHMTIEPNTFLAVP 102 Query: 116 HLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173 LE L + N I ++ SL+ L L+ N+ L GL +L + + GN Sbjct: 103 TLEELNLSYNGITTVP----ALPSSLVSLILSRTNILQLDPTSLTGLHALRFLYMDGN 156 Score = 62.8 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 26/144 (18%), Positives = 45/144 (31%), Gaps = 34/144 (23%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD-VISDDAFIG------------ 113 P + L + + G F P L+ + + N + A G Sbjct: 370 PMLQRLYLQMNFINQAQLGIFKDFPGLRYIDLSDNRISGAVEPVATTGEVDGGKKVWLTS 429 Query: 114 ----------------LPHLEY----LFIENNNIKSISRHTFRGLKSLIHLSLANNNLQT 153 +P + L + NN+ ++ F L L L L++N++ Sbjct: 430 RDLTPGPLDTPSSEDFMPSCKNLSFTLDLSRNNLVTVQPEMFAQLSRLQCLRLSHNSISQ 489 Query: 154 LPKDI-FKGLDSLTNVDLRGNSFN 176 F L SL +DL N + Sbjct: 490 AVNGSQFVPLTSLQVLDLSHNKLD 513 Score = 59.3 bits (142), Expect = 4e-09, Method: Composition-based stats. Identities = 40/217 (18%), Positives = 72/217 (33%), Gaps = 20/217 (9%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD--VISDDAFIGLPHLEYLFIEN 124 + L S +++ F +L +L + N + AF GL L L + Sbjct: 263 SRLEGLVLKDSSLYQLNPRWFRGLGNLTVLDLSENFLYDCITKTKAFQGLAQLRRLNLSF 322 Query: 125 NNIKSIS------RHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDS---LTNVDLRGNSF 175 N K +S +F L SL L + ++L + + L L + L+ N F Sbjct: 323 NYHKKVSFAHLTLAPSFGSLLSLQELDMHGIFFRSLSQKTLQPLARLPMLQRLYLQMN-F 381 Query: 176 NCDCKLKWLVEWLGHTNATVEDIYCEGP-------PEYKKRKINSLSSKDFDCIITEFAK 228 +L ++ G + D G E K L+S+D + Sbjct: 382 INQAQLGIFKDFPGLRYIDLSDNRISGAVEPVATTGEVDGGKKVWLTSRDLTPGPLDTPS 441 Query: 229 SQDLPYQSLSID-TFSYLNDEYVVIAQPFTGKCIFLE 264 S+D ++ T + V + + L+ Sbjct: 442 SEDFMPSCKNLSFTLDLSRNNLVTVQPEMFAQLSRLQ 478 Score = 50.4 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 40/232 (17%), Positives = 71/232 (30%), Gaps = 39/232 (16%) Query: 54 LCENARSIPRTVPPDVISLSFVRSGFTEIS------EGSFLFTPSLQLLLFTSNSFDVIS 107 C + + + L+ + ++S SF SLQ L F +S Sbjct: 301 DCITKTKAFQGL-AQLRRLNLSFNYHKKVSFAHLTLAPSFGSLLSLQELDMHGIFFRSLS 359 Query: 108 DDAFIGL---PHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDS 164 L P L+ L+++ N I F+ L ++ L++N + + + + Sbjct: 360 QKTLQPLARLPMLQRLYLQMNFINQAQLGIFKDFPGLRYIDLSDNRI----SGAVEPVAT 415 Query: 165 -----------LTNVDLRGNSFNC--------DCKLKWLVEWLGHTNATVEDIYCEGPPE 205 LT+ DL + CK L N P Sbjct: 416 TGEVDGGKKVWLTSRDLTPGPLDTPSSEDFMPSCKNLSFTLDLSRNNLVT-----VQPEM 470 Query: 206 YKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFT 257 + + + I SQ +P SL + S+ N + + FT Sbjct: 471 FAQLSRLQCLRLSHNSISQAVNGSQFVPLTSLQVLDLSH-NKLDLYHGRSFT 521 Score = 38.9 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 20/121 (16%), Positives = 41/121 (33%), Gaps = 6/121 (4%) Query: 127 IKSISRHTFRGLK-SLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLV 185 +KS+ + + ++ LSL +N + L F L +L ++L+ N C L Sbjct: 29 LKSVPHFSAAAPRDNVTSLSLLSNRIHHLHDSDFAQLSNLQKLNLKWN-----CPPAGLS 83 Query: 186 EWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYL 245 + T+E P ++ ++ + + L +D S Sbjct: 84 PMHFPCHMTIEPNTFLAVPTLEELNLSYNGITTVPALPSSLVSLILSRTNILQLDPTSLT 143 Query: 246 N 246 Sbjct: 144 G 144 >1XWD-C nrPDB Length = 252 Score = 100 bits (248), Expect = 2e-21, Method: Composition-based stats. Identities = 38/159 (23%), Positives = 66/159 (41%), Gaps = 30/159 (18%) Query: 45 VCTCTKDNALCENAR--SIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSN- 101 +C C+ LC+ ++ IP +P + I L FV + I +G+F L+ + + N Sbjct: 6 ICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQND 65 Query: 102 -------------------------SFDVISDDAFIGLPHLEYLFIENNNIKSISR-HTF 135 + I+ +AF LP+L+YL I N IK + H Sbjct: 66 VLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKI 125 Query: 136 RGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNV-DLRGN 173 L+ ++ N N+ T+ ++ F GL + + L N Sbjct: 126 HSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKN 164 Score = 52.4 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 23/101 (22%), Positives = 40/101 (39%), Gaps = 7/101 (6%) Query: 71 SLSFVRS-GFTEISEGSFLFTP-SLQLLLFTSNSFDVISDDAFIGLPHLEYLFIE-NNNI 127 L + I SF+ +L N I + AF G L+ L + NNN+ Sbjct: 132 LLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNG-TQLDELNLSDNNNL 190 Query: 128 KSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNV 168 + + F G + L ++ + +LP GL++L + Sbjct: 191 EELPNDVFHGASGPVILDISRTRIHSLPS---YGLENLKKL 228 Score = 45.8 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 23/85 (27%), Positives = 35/85 (41%), Gaps = 4/85 (4%) Query: 72 LSFVRSGFTEISEGSFLFTPSLQLLLFT-SNSFDVISDDAFIGLPHLEYLFIENNNIKSI 130 L ++G EI +F L L + +N+ + + +D F G L I I S+ Sbjct: 159 LWLNKNGIQEIHNCAFNG-TQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSL 217 Query: 131 SRHTFRGLKSLIHLSLANNNLQTLP 155 + LK L S N L+ LP Sbjct: 218 PSYGLENLKKLRARSTYN--LKKLP 240 Score = 28.5 bits (62), Expect = 7.8, Method: Composition-based stats. Identities = 10/74 (13%), Positives = 20/74 (27%), Gaps = 3/74 (4%) Query: 125 NNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWL 184 + + I R L + L+ + K F G L +++ N + Sbjct: 19 SKVTEIPSDLPRNAIELRFVL---TKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVF 75 Query: 185 VEWLGHTNATVEDI 198 +E Sbjct: 76 SNLPKLHEIRIEKA 89 >6O00-A nrPDB Length = 820 Score = 99.0 bits (245), Expect = 5e-21, Method: Composition-based stats. Identities = 42/149 (28%), Positives = 71/149 (47%), Gaps = 17/149 (11%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI 127 ++ L R+ +I F + L+ L + N+ + D + L +L+ L + N I Sbjct: 663 NLERLYLNRNKIEKIPTQLF-YCRKLRYLDLSHNNLTFLPADIGL-LQNLQNLAVTANRI 720 Query: 128 KSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNC------DCKL 181 +++ F+ + L L L NN LQ+LP + + L +LT ++LRGN C +C L Sbjct: 721 EALPPELFQC-RKLRALHLGNNVLQSLPSRVGE-LTNLTQIELRGNRLECLPVELGECPL 778 Query: 182 KWLVEWLGHTNATV-EDIYCEGPPEYKKR 209 L + V ED++ PPE K+R Sbjct: 779 ------LKRSGLVVEEDLFSTLPPEVKER 801 Score = 52.0 bits (123), Expect = 7e-07, Method: Composition-based stats. Identities = 34/179 (18%), Positives = 71/179 (39%), Gaps = 24/179 (13%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI 127 + L + +++ + LQ L + +I ++ + +L L + ++ Sbjct: 545 RLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDL 603 Query: 128 KSISRHTFRGLKSLIHLSLANNNLQTLPKDI-FKGLDSLTNVDLRGNSFNCDCKLKWLVE 186 + I F L +L + L +NNL+T+ + I F+ L LT + L N + ++ Sbjct: 604 ERIPHSIFS-LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYN------HIAYIPI 656 Query: 187 WLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYL 245 +G +E +Y L+ + I T+ + L Y LS + ++L Sbjct: 657 QIG-NLTNLERLY--------------LNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFL 700 >5Y3M-A nrPDB Length = 801 Score = 97.4 bits (241), Expect = 2e-20, Method: Composition-based stats. Identities = 34/155 (21%), Positives = 61/155 (39%), Gaps = 6/155 (3%) Query: 64 TVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIE 123 +P + L + + S P L+ L N +S+ + L+ L + Sbjct: 628 NLPKSLRQLRLRDNNLAFFNWSSLTVLPRLEALDLAGNQLKALSNGSLPPGIRLQKLDVS 687 Query: 124 NNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLD-SLTNVDLRGNSFNCDCKLK 182 +N+I + F LI L+L+ N L+T+ F L +L +D+ N +C C Sbjct: 688 SNSIGFVIPGFFVRATRLIELNLSANALKTVDPSWFGSLAGTLKILDVSANPLHCACGAA 747 Query: 183 WLVEWLGHTNATVEDI----YCEGPPEYKKRKINS 213 V++L V + C P + + R I + Sbjct: 748 -FVDFLLERQEAVPGLSRRVTCGSPGQLQGRSIFT 781 Score = 79.7 bits (195), Expect = 3e-15, Method: Composition-based stats. Identities = 31/135 (22%), Positives = 54/135 (40%), Gaps = 18/135 (13%) Query: 57 NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSN--------------- 101 N +PR +PP + +L + ++ +L++L N Sbjct: 189 NLTEVPRRLPPSLDTLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCRECP 248 Query: 102 -SFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNL--QTLPKDI 158 +F + D F L LE L ++++++ + + FRGL L L L+ N L I Sbjct: 249 KNFPKLHPDTFSHLSRLEGLVLKDSSLYKLEKDWFRGLGRLQVLDLSENFLYDYITKTTI 308 Query: 159 FKGLDSLTNVDLRGN 173 F L L ++L N Sbjct: 309 FNDLTQLRRLNLSFN 323 Score = 70.5 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 32/117 (27%), Positives = 47/117 (40%), Gaps = 8/117 (6%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDA------FIGLPHLEYL 120 P + LS +G + SL+ L F+ NS + + F GL +L L Sbjct: 553 PSLRYLSLAHNGIHSRVSQKLS-SASLRALDFSGNSLSQMWAEGDLYLCFFKGLRNLVQL 611 Query: 121 FIENNNIKSI-SRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFN 176 + N++ ++ RH KSL L L +NNL L L +DL GN Sbjct: 612 DLSENHLHTLLPRHLDNLPKSLRQLRLRDNNLAFFNWSSLTVLPRLEALDLAGNQLK 668 Score = 70.1 bits (170), Expect = 3e-12, Method: Composition-based stats. Identities = 38/203 (18%), Positives = 74/203 (36%), Gaps = 35/203 (17%) Query: 67 PDVISLSFVRSGFTEISEGS-FLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENN 125 + L + ++ GS F+ SL++L + N D+ +F LP LE L + N Sbjct: 474 SRLQCLRLSHNSISQAVNGSQFVPLTSLRVLDLSHNKLDLYHGRSFTELPQLEALDLSYN 533 Query: 126 NIKSISRHTFRG------LKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCD- 178 + + L SL +LSLA+N + + SL +D GNS + Sbjct: 534 SQPFSMQGVGHNLSFVAQLPSLRYLSLAHNGIHSRVSQKLSS-ASLRALDFSGNSLSQMW 592 Query: 179 -------CKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQD 231 C K L + + + +++L + D + + Sbjct: 593 AEGDLYLCFFKGLRNLVQL--------------DLSENHLHTLLPRHLDNLPKS---LRQ 635 Query: 232 LPYQSLSIDTFSYLNDEYVVIAQ 254 L + ++ F++ + V+ + Sbjct: 636 LRLRDNNLAFFNWSS--LTVLPR 656 Score = 67.8 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 2/98 (2%) Query: 79 FTEISEGSFLFTPSLQ-LLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIK-SISRHTFR 136 +S F+ + +L L + N+ I + F L L+ L + +N+I +++ F Sbjct: 437 LDAVSSKDFMPSCNLNFTLDLSRNNLVTIQQEMFTRLSRLQCLRLSHNSISQAVNGSQFV 496 Query: 137 GLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNS 174 L SL L L++N L F L L +DL NS Sbjct: 497 PLTSLRVLDLSHNKLDLYHGRSFTELPQLEALDLSYNS 534 Score = 64.7 bits (156), Expect = 1e-10, Method: Composition-based stats. Identities = 36/228 (15%), Positives = 64/228 (28%), Gaps = 54/228 (23%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD---------------------- 104 P + SL + + F PSL + + N Sbjct: 370 PKLQSLHLQLNFINQAQLSIFGAFPSLLFVDLSDNRISGAATPAAALGEVDSRVEVWRLP 429 Query: 105 ---------VISDDAFIGLPHLE-YLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL 154 +S F+ +L L + NN+ +I + F L L L L++N++ Sbjct: 430 RGLAPGPLDAVSSKDFMPSCNLNFTLDLSRNNLVTIQQEMFTRLSRLQCLRLSHNSISQA 489 Query: 155 PKDI-FKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDI------YCEGPPEYK 207 F L SL +DL N + + G + + + Y P + Sbjct: 490 VNGSQFVPLTSLRVLDLSHNKLD---------LYHGRSFTELPQLEALDLSYNSQPFSMQ 540 Query: 208 KRKIN-----SLSSKDFDCII-TEFAKSQDLPYQSLSIDTFSYLNDEY 249 N L S + + S S+ + + Sbjct: 541 GVGHNLSFVAQLPSLRYLSLAHNGIHSRVSQKLSSASLRALDFSGNSL 588 Score = 60.8 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 33/166 (19%), Positives = 58/166 (34%), Gaps = 33/166 (19%) Query: 42 CPAVCTCTKDNALCENARSIPRTVP-PDVISLSFVRSGFT-------------------- 80 CP + + C + P + L+ +G T Sbjct: 77 CPPAGL-SPMHFPCRMTIEPNTFLAVPTLEELNLSYNGITTVPALPSSLVSLSLSHTSIL 135 Query: 81 EISEGSFLFTPSLQLLLFTSN--------SFDVISDDAFIGLPHLEYLFIENNNIKSISR 132 + F +L+ L N ++ A +GL +L +L ++ NN+ + R Sbjct: 136 VLGPTHFTGLHALRFLYMDGNCYYMNPCPRALEVAPGALLGLGNLTHLSLKYNNLTEVPR 195 Query: 133 HTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCD 178 SL L L+ N++ TL + L +L +D+ GN CD Sbjct: 196 RL---PPSLDTLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCD 238 Score = 58.5 bits (140), Expect = 7e-09, Method: Composition-based stats. Identities = 35/190 (18%), Positives = 62/190 (32%), Gaps = 49/190 (25%) Query: 35 KKPAKPKCPAVCTC---TKDNALCENA--RSIPRTVP----PDVISLSFVRSGFTEISEG 85 + P + PA C C +S+P +V SLS + + + + Sbjct: 1 RSPWEGTLPAFLPCELQPHGQVDCNWLFLKSVPHFSAGAPRANVTSLSLISNRIHHLHDS 60 Query: 86 SFLFTPSLQLLLFTSN----SFD--------VISDDAFIGLPHLEYLFIENNNIKSIS-- 131 F+ +L++L N I + F+ +P LE L + N I ++ Sbjct: 61 DFVHLSNLRVLNLKWNCPPAGLSPMHFPCRMTIEPNTFLAVPTLEELNLSYNGITTVPAL 120 Query: 132 ------------------RHTFRGLKSLIHLSLANN--------NLQTLPKDIFKGLDSL 165 F GL +L L + N + GL +L Sbjct: 121 PSSLVSLSLSHTSILVLGPTHFTGLHALRFLYMDGNCYYMNPCPRALEVAPGALLGLGNL 180 Query: 166 TNVDLRGNSF 175 T++ L+ N+ Sbjct: 181 THLSLKYNNL 190 Score = 47.4 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 36/214 (16%), Positives = 69/214 (32%), Gaps = 32/214 (14%) Query: 69 VISLSFVRSGFTEIS------EGSFLFTPSLQLLLFTS---NSFDVISDDAFIGLPHLEY 119 + L+ + ++S SF SL+ L S I+ + LP L+ Sbjct: 315 LRRLNLSFNYHKKVSFAHLHLASSFGSLVSLEKLDMHGIFFRSLTNITLQSLTRLPKLQS 374 Query: 120 LFIENNNIKSISRHTFRGLKSLIHLSLANNNLQ--TLPKDIFKGLDSLTNVD-----LRG 172 L ++ N I F SL+ + L++N + P +DS V L Sbjct: 375 LHLQLNFINQAQLSIFGAFPSLLFVDLSDNRISGAATPAAALGEVDSRVEVWRLPRGLAP 434 Query: 173 NSFNC--------DCKLKWLVEWLGHTNATVEDIYCEGPPEYK--KRKINSLSS--KDFD 220 + C L + ++ + T++ + + NS+S Sbjct: 435 GPLDAVSSKDFMPSCNLNFTLDLSRNNLVTIQQEMFTRLSRLQCLRLSHNSISQAVNGSQ 494 Query: 221 CIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQ 254 + + DL + L + Y + + Q Sbjct: 495 FVPLTSLRVLDLSHNKLDL----YHGRSFTELPQ 524 >2IFG-A nrPDB Length = 347 Score = 97.0 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 41/179 (22%), Positives = 64/179 (35%), Gaps = 38/179 (21%) Query: 38 AKPKCP---AVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQ 94 CP + CT+D AL ++ +P ++ L L+ Sbjct: 2 PDACCPHGSSGLRCTRDGAL-DSLHHLPGA--ENLTELYIENQQ----------HLQHLE 48 Query: 95 LLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL 154 L GL L L I + ++ ++ F L L+L+ N L++L Sbjct: 49 LRDL-------------RGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESL 95 Query: 155 PKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINS 213 +GL SL + L GN +C C L+WL W E+ G PE K + Sbjct: 96 SWKTVQGL-SLQELVLSGNPLHCSCALRWLQRW--------EEEGLGGVPEQKLQCHGQ 145 >5YQ5-A nrPDB Length = 430 Score = 81.2 bits (199), Expect = 1e-15, Method: Composition-based stats. Identities = 25/122 (20%), Positives = 51/122 (41%), Gaps = 5/122 (4%) Query: 57 NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSF--DVISDDAFIGL 114 N P +P + L + +++ + +L +L N ++ D F + Sbjct: 150 NLEEFPFPLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDKIFAKM 209 Query: 115 PHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNS 174 L L + +N ++S+ SL++LSL NN++ ++P+ F L L + + N Sbjct: 210 EKLMQLNLCSNRLESMPPGL---PSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNK 266 Query: 175 FN 176 Sbjct: 267 LQ 268 Score = 73.9 bits (180), Expect = 2e-13, Method: Composition-based stats. Identities = 29/102 (28%), Positives = 47/102 (46%), Gaps = 6/102 (5%) Query: 54 LCENA-RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFI 112 LC N S+P +P ++ LS + + I E F P L L + N I + F Sbjct: 217 LCSNRLESMPPGLPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIPYNIF- 275 Query: 113 GLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL 154 LP++ L + +N +K F ++L HL L NN ++ + Sbjct: 276 NLPNIVELSVGHNKLK----QAFYIPRNLEHLYLQNNEIEKM 313 Score = 65.5 bits (158), Expect = 6e-11, Method: Composition-based stats. Identities = 55/292 (18%), Positives = 97/292 (33%), Gaps = 73/292 (25%) Query: 42 CPAVCTCTKD---NALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLF 98 C + C C + + C+N + I +Q L Sbjct: 60 CVSECFCPTNFPSSMYCDNRK----------------LKTIPNIPM-------HIQQLYL 96 Query: 99 TSNSFDVISDDAFIGLPHLEYLFIENNNIKS--ISRHTFRGLKSLIHLSLANNNLQTLP- 155 N + ++ ++FI HL+ + + +N IKS I F L +L+ L L +NNL+ P Sbjct: 97 QFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHLEHNNLEEFPF 156 Query: 156 --------------------KDIFKGLDSLTNVDLRGNSFNCDC---KLKWLVEWLGHTN 192 + GL +LT +DL N + K+ +E L N Sbjct: 157 PLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDKIFAKMEKLMQLN 216 Query: 193 ATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFA--------------KSQDLPYQSLS 238 + P SL + I ++ K QD+PY Sbjct: 217 LCSNRLESMPPGLPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIPYNI-- 274 Query: 239 IDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTS-TVVCKPI 289 F+ N + + + ++ ++E + + I + TV+C I Sbjct: 275 ---FNLPNIVELSVGHNKLKQAFYIP-RNLEHLYLQNNEIEKMNLTVMCPSI 322 >3WPI-A nrPDB Length = 803 Score = 78.9 bits (193), Expect = 6e-15, Method: Composition-based stats. Identities = 32/141 (22%), Positives = 60/141 (42%), Gaps = 6/141 (4%) Query: 77 SGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFR 136 + + + S F P+L++L N ++ L+ L + +N+I S+ F Sbjct: 643 NYLSFFNWTSLSFLPNLEVLDLAGNQLKALTQGTLPNGTLLQKLDVSSNSIVSVVPAFFA 702 Query: 137 GLKSLIHLSLANNNLQTLPKDIFKGL-DSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATV 195 L ++L++N L+T+ + F + LT +D+R N +C C V+ L V Sbjct: 703 LAVELKEVNLSHNILKTVDRSWFGPIVMQLTVLDVRSNPLHCACGAA-FVDLLLEVQTKV 761 Query: 196 EDIY----CEGPPEYKKRKIN 212 + C P + + R I Sbjct: 762 PGLANGVKCGSPGQLQGRSIF 782 Score = 74.7 bits (182), Expect = 9e-14, Method: Composition-based stats. Identities = 29/135 (21%), Positives = 54/135 (40%), Gaps = 18/135 (13%) Query: 57 NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSN--------------- 101 N +PR +PP + L + ++ SL++L N Sbjct: 189 NLTKVPRQLPPSLEYLLVSYNLIVKLGPEDLAQLTSLRVLDVGGNCRRCDHAPNPCIECG 248 Query: 102 -SFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNL--QTLPKDI 158 + + F L HLE L ++++++ +++ F+GL L L L+ N L + Sbjct: 249 QKSLHLHPETFHHLSHLEGLVLKDSSLHTLNSSWFQGLVQLSVLDLSENFLYESITHTNA 308 Query: 159 FKGLDSLTNVDLRGN 173 F+ L L ++L N Sbjct: 309 FQNLTRLRKLNLSFN 323 Score = 71.2 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 32/135 (23%), Positives = 58/135 (42%), Gaps = 12/135 (8%) Query: 52 NALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDV------ 105 N ++PR +P +++LS + + S SL++L N + Sbjct: 108 NLSYNGITTVPR-LPSSLVNLSLSHTNILVLDANSLAGLYSLRVLFMDGNCYYKNPCTGA 166 Query: 106 --ISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLD 163 ++ A +GL L +L ++ NN+ + R SL +L ++ N + L + L Sbjct: 167 VKVTPGALLGLSQLTHLSLKYNNLTKVPRQL---PPSLEYLLVSYNLIVKLGPEDLAQLT 223 Query: 164 SLTNVDLRGNSFNCD 178 SL +D+ GN CD Sbjct: 224 SLRVLDVGGNCRRCD 238 Score = 67.4 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 22/81 (27%), Positives = 39/81 (48%), Gaps = 1/81 (1%) Query: 95 LLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI-KSISRHTFRGLKSLIHLSLANNNLQT 153 + + N+ I + F+ L L+ L + +N+I ++++ F L +L L L++N L Sbjct: 456 TMDLSRNNLVTIKPEMFVQLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDL 515 Query: 154 LPKDIFKGLDSLTNVDLRGNS 174 F L L +DL NS Sbjct: 516 YHWKSFSELPQLQALDLSYNS 536 Score = 67.0 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 25/110 (22%), Positives = 43/110 (39%), Gaps = 7/110 (6%) Query: 71 SLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSF-DVISDDAFIGLPHLEYLFIENNNIKS 129 ++ R+ I F+ LQ L + NS ++ F+ L +L+ L + +N + Sbjct: 456 TMDLSRNNLVTIKPEMFVQLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDL 515 Query: 130 ISRHTFRGLKSLIHLSLANNNLQTLPKDI------FKGLDSLTNVDLRGN 173 +F L L L L+ N+ K I L L ++ L N Sbjct: 516 YHWKSFSELPQLQALDLSYNSQPFSMKGIGHQFSFVTHLSMLQSLSLAHN 565 Score = 63.1 bits (152), Expect = 3e-10, Method: Composition-based stats. Identities = 29/123 (23%), Positives = 45/123 (36%), Gaps = 19/123 (15%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENN- 125 + LS + T++ PSL+ LL + N + + L L L + N Sbjct: 178 SQLTHLSLKYNNLTKVPR---QLPPSLEYLLVSYNLIVKLGPEDLAQLTSLRVLDVGGNC 234 Query: 126 ---------------NIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDL 170 + TF L L L L +++L TL F+GL L+ +DL Sbjct: 235 RRCDHAPNPCIECGQKSLHLHPETFHHLSHLEGLVLKDSSLHTLNSSWFQGLVQLSVLDL 294 Query: 171 RGN 173 N Sbjct: 295 SEN 297 Score = 63.1 bits (152), Expect = 3e-10, Method: Composition-based stats. Identities = 30/132 (22%), Positives = 53/132 (40%), Gaps = 20/132 (15%) Query: 58 ARSIPRTVP----PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSN----SFD----- 104 +S+PR ++ LS + + + F+ +L+ L N Sbjct: 29 LKSVPRFSAAASCSNITRLSLISNRIHHLHNSDFVHLSNLRQLNLKWNCPPTGLSPLHFS 88 Query: 105 ---VISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKG 161 I F+ + LE L + N I ++ R SL++LSL++ N+ L + G Sbjct: 89 CHMTIEPRTFLAMRTLEELNLSYNGITTVP----RLPSSLVNLSLSHTNILVLDANSLAG 144 Query: 162 LDSLTNVDLRGN 173 L SL + + GN Sbjct: 145 LYSLRVLFMDGN 156 Score = 62.4 bits (150), Expect = 5e-10, Method: Composition-based stats. Identities = 29/114 (25%), Positives = 47/114 (41%), Gaps = 8/114 (7%) Query: 67 PDVISLSFVRSGFTEISEGS-FLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENN 125 + LS + + GS FL +LQ+L + N D+ +F LP L+ L + N Sbjct: 476 SRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYN 535 Query: 126 NIKSISRHTFR------GLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173 + + L L LSLA+N++ T +S+ +D GN Sbjct: 536 SQPFSMKGIGHQFSFVTHLSMLQSLSLAHNDIHTRVSSHLNS-NSVRFLDFSGN 588 Score = 52.0 bits (123), Expect = 7e-07, Method: Composition-based stats. Identities = 22/114 (19%), Positives = 38/114 (33%), Gaps = 11/114 (9%) Query: 72 LSFVRSGF--TEISEGSFLFTPSLQLLLFTSNSFDVIS------DDAFIGLPHLEYLFIE 123 L + + +F L+ L + N +S +F L L+ L + Sbjct: 292 LDLSENFLYESITHTNAFQNLTRLRKLNLSFNYRKKVSFARLHLASSFKNLVSLQELNMN 351 Query: 124 NNNIKSISRH---TFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNS 174 + ++++ L L L L N + IF +L VDL N Sbjct: 352 GIFFRLLNKYTLRWLADLPKLHTLHLQMNFINQAQLSIFGTFRALRFVDLSDNR 405 Score = 50.4 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 24/145 (16%), Positives = 46/145 (31%), Gaps = 35/145 (24%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD---------------------- 104 P + +L + + F +L+ + + N Sbjct: 370 PKLHTLHLQMNFINQAQLSIFGTFRALRFVDLSDNRISGPSTLSEATPEEADDAEQEELL 429 Query: 105 VISDD-AFIGLPHLEY-----------LFIENNNIKSISRHTFRGLKSLIHLSLANNNL- 151 A + P + + + NN+ +I F L L LSL++N++ Sbjct: 430 SADPHPAPLSTPASKNFMDRCKNFKFTMDLSRNNLVTIKPEMFVQLSRLQCLSLSHNSIA 489 Query: 152 QTLPKDIFKGLDSLTNVDLRGNSFN 176 Q + F L +L +DL N + Sbjct: 490 QAVNGSQFLPLTNLQVLDLSHNKLD 514 Score = 39.6 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 18/94 (19%), Positives = 33/94 (35%), Gaps = 9/94 (9%) Query: 68 DVISLSFVRSGFTEIS------EGSFLFTPSLQLLLFTS---NSFDVISDDAFIGLPHLE 118 + L+ + ++S SF SLQ L + + LP L Sbjct: 314 RLRKLNLSFNYRKKVSFARLHLASSFKNLVSLQELNMNGIFFRLLNKYTLRWLADLPKLH 373 Query: 119 YLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQ 152 L ++ N I F ++L + L++N + Sbjct: 374 TLHLQMNFINQAQLSIFGTFRALRFVDLSDNRIS 407 >6HLU-A nrPDB Length = 974 Score = 74.7 bits (182), Expect = 1e-13, Method: Composition-based stats. Identities = 44/196 (22%), Positives = 68/196 (34%), Gaps = 19/196 (9%) Query: 62 PRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLF 121 P + L + T+I+ SL L + N+ I+ L L L Sbjct: 152 PLESLKSLTELQLSSNQITDIAP--LASLKSLTELSLSGNNISDIAP--LESLKSLTELS 207 Query: 122 IENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKL 181 + +N I I+ LKSL LSL++N + + + L SLT + L N + L Sbjct: 208 LSSNQITDIAP--LASLKSLTELSLSSNQISDIAP--LESLKSLTELQLSRNQISDIAPL 263 Query: 182 KWLVEWLGHTNATVEDIYCEGP-PEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID 240 + L L + I P K LS I P +SL+ Sbjct: 264 ESLKS-LTELQLSSNQITDIAPLASLKSLTELQLSRNQISDIA---------PLESLNSL 313 Query: 241 TFSYLNDEYVVIAQPF 256 + +LN + P Sbjct: 314 SKLWLNGNQITDIAPL 329 Score = 71.2 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 26/113 (23%), Positives = 41/113 (36%), Gaps = 8/113 (7%) Query: 62 PRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLF 121 P + L + T+I+ SL L + N I+ L L L+ Sbjct: 262 PLESLKSLTELQLSSNQITDIAP--LASLKSLTELQLSRNQISDIAP--LESLNSLSKLW 317 Query: 122 IENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNS 174 + N I I+ L SL L L++N + + L SL+ + L N Sbjct: 318 LNGNQITDIAP--LASLNSLTELELSSNQITDIAP--LASLKSLSTLWLSSNQ 366 Score = 58.9 bits (141), Expect = 6e-09, Method: Composition-based stats. Identities = 45/179 (25%), Positives = 66/179 (36%), Gaps = 20/179 (11%) Query: 77 SGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFR 136 + T+IS SL +L N I+ L L L++ N I I+ Sbjct: 101 NQITDISP--LASLNSLSMLWLDRNQITDIAP--LASLNSLSMLWLFGNKISDIAP--LE 154 Query: 137 GLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVE 196 LKSL L L++N + + L SLT + L GN+ + L+ L L + + Sbjct: 155 SLKSLTELQLSSNQITDIAP--LASLKSLTELSLSGNNISDIAPLESLKS-LTELSLSSN 211 Query: 197 DIYCEGP-PEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSL-SIDTFSYLNDEYVVIA 253 I P K SLSS I P +SL S+ ++ IA Sbjct: 212 QITDIAPLASLKSLTELSLSSNQISDIA---------PLESLKSLTELQLSRNQISDIA 261 Score = 53.5 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 29/107 (27%), Positives = 46/107 (42%), Gaps = 8/107 (7%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI 127 + L + T+I+ SL L +SN I+ L L L++ +N I Sbjct: 312 SLSKLWLNGNQITDIAP--LASLNSLTELELSSNQITDIAP--LASLKSLSTLWLSSNQI 367 Query: 128 KSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNS 174 I+ L+SL LSL++N + + L+SLT D+R N Sbjct: 368 SDIAP--LASLESLSELSLSSNQISDISP--LASLNSLTGFDVRRNP 410 Score = 38.1 bits (87), Expect = 0.011, Method: Composition-based stats. Identities = 31/133 (23%), Positives = 52/133 (39%), Gaps = 16/133 (12%) Query: 123 ENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLK 182 +N I IS L SL L L N + + L+SL+ + L GN + L+ Sbjct: 99 SSNQITDISP--LASLNSLSMLWLDRNQITDIAP--LASLNSLSMLWLFGNKISDIAPLE 154 Query: 183 WLVEW--LGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID 240 L L ++ + DI P + + LS + I++ A + L S+ Sbjct: 155 SLKSLTELQLSSNQITDI----APLASLKSLTELSLSGNN--ISDIAPLESLK----SLT 204 Query: 241 TFSYLNDEYVVIA 253 S +++ IA Sbjct: 205 ELSLSSNQITDIA 217 >5XJX-C nrPDB Length = 433 Score = 68.2 bits (165), Expect = 9e-12, Method: Composition-based stats. Identities = 29/115 (25%), Positives = 46/115 (40%), Gaps = 2/115 (1%) Query: 60 SIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEY 119 SIP V P + L ++ T + SL + + N ++ L L Sbjct: 195 SIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVL 254 Query: 120 LFIENNNIKSISRHTFRGLKSLIHLSLANNN--LQTLPKDIFKGLDSLTNVDLRG 172 L + N + + +GL SL L L N T+P++ FKGL +L + L Sbjct: 255 LDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSN 309 Score = 64.3 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 61/316 (19%), Positives = 106/316 (33%), Gaps = 48/316 (15%) Query: 5 RSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKC-PAVCTCTKDNALCENARSI-- 61 R + G C+P + Y + LS L++ A P C P ++ ++ +++ Sbjct: 55 RGRWHGIECMPDQDNVYHVVSLSFGALSD--DTAFPTCDPQRSYVSESLTRLKHLKALFF 112 Query: 62 -------PRTVP-------PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVIS 107 P+ +P + +L +GF +L++L N + Sbjct: 113 YRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSI 172 Query: 108 DDAFIGLPHLEYLFIENNNIK-SISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLT 166 +F L L + N + SI L +L L L N L SL Sbjct: 173 PLSFNRFSGLRSLDLSGNRLTGSIPGFV---LPALSVLDLNQNLLTGPVPPTLTSCGSLI 229 Query: 167 NVDLRGNSFNCDCKLKWLVEWLGH-TNATVEDIYCEGPPEYKKRKINSLS------SKDF 219 +DL N + + L + GP + +NSL + F Sbjct: 230 KIDLSRNRV--TGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKF 287 Query: 220 DCII--TEFAKSQDLPYQSLSID--------TFSYLNDEYV--VIAQPFTGKCIFLEWD- 266 I F ++L LS + + LN V + TG+ I LE+ Sbjct: 288 STTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGE-IPLEFRD 346 Query: 267 --HVEKTFRNYDNITG 280 H+ + N +++TG Sbjct: 347 VKHLSELRLNDNSLTG 362 Score = 57.8 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 29/174 (16%), Positives = 55/174 (31%), Gaps = 37/174 (21%) Query: 39 KPKCPAVCTCTKDNALCENARSIPRTVPPD------VISLSFVRSGF------------- 79 P P + +C + + + +P ++ L + Sbjct: 216 GPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGPFPSSLQGLNS 275 Query: 80 -------------TEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNN 126 T I E +F +L +L+ ++ + + L L L +E NN Sbjct: 276 LQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNN 335 Query: 127 IKSISRHTFRGLKSLIHLSLANNNLQ---TLPKDIFKGLDSLTNVDLRGNSFNC 177 + FR +K L L L +N+L +D + + L N+ C Sbjct: 336 LTGEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMRR--KLRLYNNAGLC 387 >4PUF-A nrPDB Length = 637 Score = 67.4 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 30/115 (26%), Positives = 52/115 (45%), Gaps = 11/115 (9%) Query: 53 ALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPS-LQLLLFTSNSFDVISDDAF 111 A SIP T+P + + + TE+ E PS LQ L N + ++ Sbjct: 99 ANSNQLTSIPATLPDTIQEMELSINRITELPE----RLPSALQSLDLFHNKISCLPENLP 154 Query: 112 IGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLT 166 L YL + +N+I+++ H + HL++ +N+L LP+ + GL +L Sbjct: 155 E---ELRYLSVYDNSIRTLPAHL---PSEITHLNVQSNSLTALPETLPPGLKTLE 203 Score = 58.1 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 30/202 (14%), Positives = 67/202 (33%), Gaps = 27/202 (13%) Query: 57 NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPH 116 +IP +P + +L + + E +++ L SN I + Sbjct: 61 GLTTIPAYIPEQITTLILDNNELKSLPE---NLQGNIKTLYANSNQLTSIPATLPDTIQE 117 Query: 117 LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVD--LRGNS 174 +E + N I + +L L L +N + LP+++ + L L+ D +R Sbjct: 118 ME---LSINRITELPERL---PSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLP 171 Query: 175 FNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPY 234 + ++ L ++ + + PP K + + LP Sbjct: 172 AHLPSEITHL-NVQSNSLTALPETL---PPGLKTLEAGE---NALTSLPAS------LPP 218 Query: 235 QSLSIDTFSYLNDEYVVIAQPF 256 + +D ++ V+ + Sbjct: 219 ELQVLDV---SKNQITVLPETL 237 Score = 57.8 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 19/108 (17%), Positives = 42/108 (38%), Gaps = 9/108 (8%) Query: 59 RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLE 118 R++P +P ++ L+ + T + E +L+ N+ + P L+ Sbjct: 168 RTLPAHLPSEITHLNVQSNSLTALPETLPPGLKTLEA---GENALTSLPASL---PPELQ 221 Query: 119 YLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLT 166 L + N I + ++ L ++ N L LP+++ L + Sbjct: 222 VLDVSKNQITVLPETL---PPTITTLDVSRNALTNLPENLPAALQIMQ 266 Score = 49.7 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 13/79 (16%), Positives = 32/79 (40%), Gaps = 6/79 (7%) Query: 58 ARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHL 117 S+P ++PP++ L ++ T + E P++ L + N+ + ++ L + Sbjct: 209 LTSLPASLPPELQVLDVSKNQITVLPETLP---PTITTLDVSRNALTNLPENLPAALQIM 265 Query: 118 EYLFIENNNIKSISRHTFR 136 + NN+ + Sbjct: 266 QA---SRNNLVRLPESLPH 281 Score = 35.8 bits (81), Expect = 0.045, Method: Composition-based stats. Identities = 14/58 (24%), Positives = 26/58 (44%), Gaps = 7/58 (12%) Query: 61 IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLE 118 +P T+PP + +L R+ T + E LQ++ + N+ + + LPH Sbjct: 233 LPETLPPTITTLDVSRNALTNLPENLPAA---LQIMQASRNNLVRLPE----SLPHFR 283 >6HKW-A nrPDB Length = 363 Score = 67.0 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 28/149 (18%), Positives = 56/149 (37%), Gaps = 8/149 (5%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI 127 ++ SL ++ T++ +L +L SN I + L +L L++ +N I Sbjct: 212 NLESLFLGKNKITKLQN--LDALTNLTVLSMQSNRLTKI--EGLQNLVNLRELYLSHNGI 267 Query: 128 KSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEW 187 + I L L +A+N ++ + L L + N L L Sbjct: 268 EVI--EGLENNNKLTMLDIASNRIKKIEN--ISHLTELQEFWMNDNLLESWSDLDELKGA 323 Query: 188 LGHTNATVEDIYCEGPPEYKKRKINSLSS 216 +E + P+Y+++ + +L S Sbjct: 324 RSLETVYLERNPLQKDPQYRRKVMLALPS 352 Score = 58.9 bits (141), Expect = 5e-09, Method: Composition-based stats. Identities = 31/166 (18%), Positives = 55/166 (33%), Gaps = 17/166 (10%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI 127 V +L ++ I SL+ L N I + L LE L I N + Sbjct: 102 KVKTLCLRQNLIKCIEN--LEELQSLRELDLYDNQIKKIEN--LEALTELEILDISFNLL 157 Query: 128 KSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEW 187 ++I L L L L NN + + L L ++L N + L Sbjct: 158 RNI--EGVDKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRIRAIENIDTLTN- 212 Query: 188 LGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCI-ITEFAKSQDL 232 +E ++ K + +++L++ + K + L Sbjct: 213 -------LESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGL 251 Score = 55.8 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 22/132 (16%), Positives = 46/132 (34%), Gaps = 12/132 (9%) Query: 69 VISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIK 128 + L + I +L+ L N + + L +L L +++N + Sbjct: 191 LQMLELGSNRIRAIEN--IDTLTNLESLFLGKNKITKLQN--LDALTNLTVLSMQSNRLT 246 Query: 129 SISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVE-- 186 I + L +L L L++N ++ + + + LT +D+ N + L E Sbjct: 247 KI--EGLQNLVNLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKKIENISHLTELQ 302 Query: 187 --WLGHTNATVE 196 W+ Sbjct: 303 EFWMNDNLLESW 314 Score = 44.3 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 18/80 (22%), Positives = 32/80 (40%), Gaps = 6/80 (7%) Query: 94 QLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQT 153 + + I + F L ++ L + N IK I L+SL L L +N ++ Sbjct: 82 EDVDLNHYRIGKI--EGFEVLKKVKTLCLRQNLIKCI--ENLEELQSLRELDLYDNQIKK 137 Query: 154 LPKDIFKGLDSLTNVDLRGN 173 + + L L +D+ N Sbjct: 138 IEN--LEALTELEILDISFN 155 >3CVR-A nrPDB Length = 571 Score = 61.2 bits (147), Expect = 1e-09, Method: Composition-based stats. Identities = 39/186 (20%), Positives = 68/186 (36%), Gaps = 27/186 (14%) Query: 57 NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLP- 115 N S+P +PP + L ++ + E SL+ L N + + LP Sbjct: 70 NLSSLPDNLPPQITVLEITQNALISLPE----LPASLEYLDACDNRLSTLPE-----LPA 120 Query: 116 HLEYLFIENNNIKSISRHTFRGLKS-LIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNS 174 L++L ++NN + + L + L +++ NN L LP + SL + +R N Sbjct: 121 SLKHLDVDNNQLTMLPE-----LPALLEYINADNNQLTMLP----ELPTSLEVLSVRNNQ 171 Query: 175 FNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPY 234 L L E L ++ P + + + F C +P Sbjct: 172 LT---FLPELPESL-EALDVSTNLLESLPAVPVRNHHSEETEIFFRCRENRITH---IPE 224 Query: 235 QSLSID 240 LS+D Sbjct: 225 NILSLD 230 Score = 51.6 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 22/102 (21%), Positives = 42/102 (41%), Gaps = 14/102 (13%) Query: 55 CENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPS-LQLLLFTSNSFDVISDDAFIG 113 C+N S +P + L + T + E P+ L+ + +N ++ + Sbjct: 108 CDNRLSTLPELPASLKHLDVDNNQLTMLPE-----LPALLEYINADNNQLTMLPELP--- 159 Query: 114 LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLP 155 LE L + NN + + +SL L ++ N L++LP Sbjct: 160 -TSLEVLSVRNNQLTFLPE----LPESLEALDVSTNLLESLP 196 >1M9S-A nrPDB Length = 605 Score = 58.9 bits (141), Expect = 6e-09, Method: Composition-based stats. Identities = 32/127 (25%), Positives = 46/127 (36%), Gaps = 26/127 (20%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSF-------------------DVIS 107 P+V L + T+I +L L N + IS Sbjct: 65 PNVTKLFLNGNKLTDIKP--LTNLKNLGWLFLDENKIKDLSSLKDLKKLKSLSLEHNGIS 122 Query: 108 D-DAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLT 166 D + + LP LE L++ NN I I+ L L LSL +N + + GL L Sbjct: 123 DINGLVHLPQLESLYLGNNKITDIT--VLSRLTKLDTLSLEDNQISDIVP--LAGLTKLQ 178 Query: 167 NVDLRGN 173 N+ L N Sbjct: 179 NLYLSKN 185 Score = 55.1 bits (131), Expect = 8e-08, Method: Composition-based stats. Identities = 21/82 (25%), Positives = 31/82 (37%), Gaps = 6/82 (7%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNN 126 P + SL + T+I L L N I GL L+ L++ N+ Sbjct: 131 PQLESLYLGNNKITDI--TVLSRLTKLDTLSLEDNQISDIVP--LAGLTKLQNLYLSKNH 186 Query: 127 IKSISRHTFRGLKSLIHLSLAN 148 I + GLK+L L L + Sbjct: 187 ISDL--RALAGLKNLDVLELFS 206 Score = 45.8 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 28/169 (16%), Positives = 51/169 (30%), Gaps = 32/169 (18%) Query: 77 SGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKS------- 129 + S + P++ L N I L +L +LF++ N IK Sbjct: 51 NNSDIKSVQGIQYLPNVTKLFLNGNKLTDIKP--LTNLKNLGWLFLDENKIKDLSSLKDL 108 Query: 130 -------------ISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFN 176 + L L L L NN + + + L L + L N + Sbjct: 109 KKLKSLSLEHNGISDINGLVHLPQLESLYLGNNKITDI--TVLSRLTKLDTLSLEDNQIS 166 Query: 177 CDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITE 225 L L ++++Y R + L + D + ++ Sbjct: 167 DIVPLAGL--------TKLQNLYLSKNHISDLRALAGLKNLDVLELFSQ 207 >1OGQ-A nrPDB Length = 313 Score = 55.8 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 34/176 (19%), Positives = 62/176 (35%), Gaps = 4/176 (2%) Query: 60 SIPRTVPP--DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHL 117 +IP + +++L F + + S P+L + F N D++ L Sbjct: 116 AIPDFLSQIKTLVTLDFSYNALSGTLPPSISSLPNLVGITFDGNRISGAIPDSYGSFSKL 175 Query: 118 -EYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFN 176 + I N + TF L +L + L+ N L+ +F + + L NS Sbjct: 176 FTSMTISRNRLTGKIPPTFANL-NLAFVDLSRNMLEGDASVLFGSDKNTQKIHLAKNSLA 234 Query: 177 CDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDL 232 D L + L + IY P + K + F+ + E + +L Sbjct: 235 FDLGKVGLSKNLNGLDLRNNRIYGTLPQGLTQLKFLHSLNVSFNNLCGEIPQGGNL 290 Score = 43.5 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 17/122 (13%), Positives = 37/122 (30%), Gaps = 8/122 (6%) Query: 62 PRTVPPDVISLSFVR-------SGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGL 114 P +P + +L ++ + + L L T + D + Sbjct: 65 PYPIPSSLANLPYLNFLYIGGINNLVGPIPPAIAKLTQLHYLYITHTNVSGAIPDFLSQI 124 Query: 115 PHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSL-TNVDLRGN 173 L L N + + L +L+ ++ N + D + L T++ + N Sbjct: 125 KTLVTLDFSYNALSGTLPPSISSLPNLVGITFDGNRISGAIPDSYGSFSKLFTSMTISRN 184 Query: 174 SF 175 Sbjct: 185 RL 186 >3G06-A nrPDB Length = 622 Score = 55.4 bits (132), Expect = 6e-08, Method: Composition-based stats. Identities = 47/231 (20%), Positives = 76/231 (32%), Gaps = 36/231 (15%) Query: 40 PKC-PAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLF 98 P C PA T N S+P +PP++ +L + T + + P L L Sbjct: 56 PDCLPA--HITTLVIPDNNLTSLPA-LPPELRTLEVSGNQLTSLP----VLPPGLLELSI 108 Query: 99 TSNSFDVISDDAFIGLPH-LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD 157 SN + LP L L+I N + S+ L LS+++N L +LP Sbjct: 109 FSNPLTHLPA-----LPSGLCKLWIFGNQLTSLPV----LPPGLQELSVSDNQLASLP-- 157 Query: 158 IFKGLDS-LTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYC--EGPPEYKK-----R 209 L S L + N L L L + + + P E K Sbjct: 158 ---ALPSELCKLWAYNNQLT---SLPMLPSGLQELSVSDNQLASLPTLPSELYKLWAYNN 211 Query: 210 KINSLSSK--DFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTG 258 ++ SL + +I + LP + + + +G Sbjct: 212 RLTSLPALPSGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSG 262 Score = 50.4 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 36/168 (21%), Positives = 59/168 (35%), Gaps = 32/168 (19%) Query: 26 LSALLLTEGKKPAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEG 85 L L +++ + + P P+ C S+P +P + LS + + Sbjct: 143 LQELSVSDNQLASLPALPSE-LCKLWAYN-NQLTSLPM-LPSGLQELSVSDNQLASLPT- 198 Query: 86 SFLFTPS-LQLLLFTSNSFDVISDDAFIGLPH-LEYLFIENNNIKSIS--RHTFRGL--- 138 PS L L +N + LP L+ L + N + S+ + L Sbjct: 199 ----LPSELYKLWAYNNRLTSLPA-----LPSGLKELIVSGNRLTSLPVLPSELKELMVS 249 Query: 139 -----------KSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSF 175 L+ LS+ N L LP+ + L S T V+L GN Sbjct: 250 GNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIH-LSSETTVNLEGNPL 296 Score = 45.8 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 31/190 (16%), Positives = 56/190 (29%), Gaps = 45/190 (23%) Query: 72 LSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSIS 131 L+ SG T + L + L+ N+ + P L L + N + S+ Sbjct: 45 LNVGESGLTTLP--DCLPA-HITTLVIPDNNLTSLPALP----PELRTLEVSGNQLTSLP 97 Query: 132 RHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDS-LTNVDLRGNSFNCDCKLKWLVEWLGH 190 L+ LS+ +N L LP L S L + + GN Sbjct: 98 V----LPPGLLELSIFSNPLTHLP-----ALPSGLCKLWIFGNQLT-------------- 134 Query: 191 TNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAK-------SQDLPYQSLSIDTFS 243 PP ++ ++ + +E K LP + S Sbjct: 135 -------SLPVLPPGLQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPMLPSGLQELS 187 Query: 244 YLNDEYVVIA 253 +++ + Sbjct: 188 VSDNQLASLP 197 >6ICZ-o nrPDB Length = 255 Score = 52.7 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 26/108 (24%), Positives = 35/108 (32%), Gaps = 4/108 (3%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI 127 L I + F+ N + F L L+ L + NN I Sbjct: 20 RDRELDLRGYKIPVIENLG-ATLDQFDAIDFSDNEIRKLDG--FPLLRRLKTLLVNNNRI 76 Query: 128 KSISRHTFRGLKSLIHLSLANNNLQTLPK-DIFKGLDSLTNVDLRGNS 174 I + L L L L NN+L L D L SLT + + N Sbjct: 77 CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNP 124 Score = 40.8 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 22/90 (24%), Positives = 32/90 (35%), Gaps = 4/90 (4%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISD-DAFIGLPHLEYLFIENN 125 + +L + I EG P L L+ T+NS + D D L L YL I N Sbjct: 64 RRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRN 123 Query: 126 ---NIKSISRHTFRGLKSLIHLSLANNNLQ 152 N K + + + L L+ Sbjct: 124 PVTNKKHYRLYVIYKVPQVRVLDFQKVKLK 153 Score = 37.7 bits (86), Expect = 0.012, Method: Composition-based stats. Identities = 18/82 (21%), Positives = 34/82 (41%), Gaps = 3/82 (3%) Query: 94 QLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQT 153 + L VI ++ L + + +N I+ + F L+ L L + NN + Sbjct: 22 RELDLRGYKIPVI-ENLGATLDQFDAIDFSDNEIRKLDG--FPLLRRLKTLLVNNNRICR 78 Query: 154 LPKDIFKGLDSLTNVDLRGNSF 175 + + + + L LT + L NS Sbjct: 79 IGEGLDQALPCLTELILTNNSL 100 >3JB9-j nrPDB Length = 239 Score = 52.4 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 29/123 (23%), Positives = 45/123 (36%), Gaps = 13/123 (10%) Query: 58 ARSIPRTVPP-DVISLSFVRSGFTEISE-GSFLFTPSLQLLLFTSNSFDVISDDAFIGLP 115 +P + P L I G + FT N + + F + Sbjct: 8 LSQVPSFISPLKETELDLRWYQIPIIENLGVLRDVHD--AIDFTDNDIRYLGN--FPRMK 63 Query: 116 HLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTL----PKDIFKGLDSLTNVDLR 171 L+ L NN I +I+ + L +L LSLA N+LQ + P L +L+ +D Sbjct: 64 RLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIADLDPLASCPQLTNLSCID-- 121 Query: 172 GNS 174 N Sbjct: 122 -NP 123 Score = 51.2 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 20/81 (24%), Positives = 36/81 (44%), Gaps = 3/81 (3%) Query: 72 LSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSIS 131 + F + + G+F LQ LL +N I+ D LP+L+ L + N+++ I+ Sbjct: 46 IDFTDNDIRYL--GNFPRMKRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIA 103 Query: 132 R-HTFRGLKSLIHLSLANNNL 151 L +LS +N + Sbjct: 104 DLDPLASCPQLTNLSCIDNPV 124 >1JL5-A nrPDB Length = 454 Score = 52.4 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 21/128 (16%), Positives = 43/128 (33%), Gaps = 27/128 (21%) Query: 63 RTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFI 122 +PP++ L+ + + PSL+ L ++N + P LE L Sbjct: 293 SELPPNLYYLNASSNEIRSL----CDLPPSLEELNVSNNKLIELPALP----PRLERLIA 344 Query: 123 ENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPK--DIFKGLD-------------SLTN 167 N++ + ++L L + N L+ P + + L +L Sbjct: 345 SFNHLAEVPE----LPQNLKQLHVEYNPLREFPDIPESVEDLRMNSHLAEVPELPQNLKQ 400 Query: 168 VDLRGNSF 175 + + N Sbjct: 401 LHVETNPL 408 Score = 51.6 bits (122), Expect = 9e-07, Method: Composition-based stats. Identities = 43/208 (20%), Positives = 76/208 (36%), Gaps = 25/208 (12%) Query: 57 NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPH 116 S+P +PP + SL + TE+ E SL+ LL +N+ +SD P Sbjct: 82 GLSSLP-ELPPHLESLVASCNSLTELPE----LPQSLKSLLVDNNNLKALSDLP----PL 132 Query: 117 LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFN 176 LEYL + NN ++ + + L + + NN+L+ LP SL + N Sbjct: 133 LEYLGVSNNQLEKLPE--LQNSSFLKIIDVDNNSLKKLPD--LPP--SLEFIAAGNNQLE 186 Query: 177 ---CDCKLKWLVEWLGHTNA--TVEDIYCEGPPEYKKRKIN----SLSSKDFD-CIITEF 226 L +L N+ + D+ I L + F I + Sbjct: 187 ELPELQNLPFLTAIYADNNSLKKLPDLPLSLESIVAGNNILEELPELQNLPFLTTIYADN 246 Query: 227 AKSQDLPYQSLSIDTFSYLNDEYVVIAQ 254 + LP S++ + ++ + + Sbjct: 247 NLLKTLPDLPPSLEALNVRDNYLTDLPE 274 Score = 51.2 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 24/112 (21%), Positives = 42/112 (37%), Gaps = 16/112 (14%) Query: 64 TVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIE 123 +P + L + F+ +SE P+L L +SN + D P LE L + Sbjct: 274 ELPQSLTFLDVSENIFSGLSE----LPPNLYYLNASSNEIRSLCDLP----PSLEELNVS 325 Query: 124 NNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSF 175 NN + + L L + N+L +P + +L + + N Sbjct: 326 NNKLIELP----ALPPRLERLIASFNHLAEVP----ELPQNLKQLHVEYNPL 369 >5KH1-A nrPDB Length = 591 Score = 50.8 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 28/119 (23%), Positives = 50/119 (42%), Gaps = 21/119 (17%) Query: 57 NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTP-SLQLLLFTSNSFDVISDDAFIGLP 115 ++P +PP + S++ ++ + IS P SL L + N + LP Sbjct: 78 GLTTLP-EIPPGIKSINISKNNLSLIS-----PLPASLTQLNVSYNRLIELPA-----LP 126 Query: 116 H-LEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGN 173 L+ L +N + ++ SL L ++NN L +LP + L L +D+ N Sbjct: 127 QGLKLLNASHNQLITLP----TLPISLKELHVSNNQLCSLP--VLPEL--LETLDVSCN 177 Score = 40.8 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 24/123 (19%), Positives = 41/123 (33%), Gaps = 24/123 (19%) Query: 50 KDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVIS-- 107 K + +N S+ +P + L+ + E+ L+LL + N + Sbjct: 90 KSINISKNNLSLISPLPASLTQLNVSYNRLIELPA----LPQGLKLLNASHNQLITLPTL 145 Query: 108 ----------DDAFIGLP----HLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQT 153 ++ LP LE L + N + + F SL +S N L Sbjct: 146 PISLKELHVSNNQLCSLPVLPELLETLDVSCNGLAVLPPLPF----SLQEISAIGNLLSE 201 Query: 154 LPK 156 LP Sbjct: 202 LPP 204 Score = 34.6 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 21/116 (18%), Positives = 41/116 (35%), Gaps = 21/116 (18%) Query: 65 VPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVIS------------DDAFI 112 +P + +L +G + F SLQ + N + D+ Sbjct: 165 LPELLETLDVSCNGLAVLPPLPF----SLQEISAIGNLLSELPPLPHNIHSIWAIDNMLT 220 Query: 113 GLPHL-EYL---FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDS 164 +P+L E L + + N I I L++ + +++N L + + L S Sbjct: 221 DIPYLPENLRNGYFDINQISHIPESIL-NLRNECSIDISDNPLSSHALQSLQRLTS 275 Score = 28.9 bits (63), Expect = 5.5, Method: Composition-based stats. Identities = 12/60 (20%), Positives = 21/60 (35%), Gaps = 5/60 (8%) Query: 58 ARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHL 117 IP +P ++ + F + + I E S L + + + N A L L Sbjct: 219 LTDIP-YLPENLRNGYFDINQISHIPE-SILNLRNECSIDISDNPLSS---HALQSLQRL 273 >5YXM-A nrPDB Length = 203 Score = 50.4 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 29/155 (18%), Positives = 62/155 (40%), Gaps = 10/155 (6%) Query: 86 SFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLS 145 + + + L ++N+ + IS + G+ +L L + N IK I + +L L Sbjct: 48 TLSTLKACKHLALSTNNIEKIS--SLSGMENLRILSLGRNLIKKI-ENLDAVADTLEELW 104 Query: 146 LANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPE 205 ++ N + +L + L +L + + N ++ L +ED+ G P Sbjct: 105 ISYNQIASLSG--IEKLVNLRVLYMSNNKITNWGEIDKLA-----ALDKLEDLLLAGNPL 157 Query: 206 YKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID 240 Y K N+ +S+ ++ + L + +D Sbjct: 158 YNDYKENNATSEYRIEVVKRLPNLKKLDGMPVDVD 192 Score = 44.7 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 25/114 (21%), Positives = 41/114 (35%), Gaps = 14/114 (12%) Query: 67 PDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNN 126 ++ LS R+ +I + L+ L + N +S L +L L++ NN Sbjct: 75 ENLRILSLGRNLIKKIENLDAVADT-LEELWISYNQIASLSG--IEKLVNLRVLYMSNNK 131 Query: 127 IKSISR-HTFRGLKSLIHLSLANNNL----------QTLPKDIFKGLDSLTNVD 169 I + L L L LA N L ++ K L +L +D Sbjct: 132 ITNWGEIDKLAALDKLEDLLLAGNPLYNDYKENNATSEYRIEVVKRLPNLKKLD 185 >4ECN-A nrPDB Length = 876 Score = 48.1 bits (113), Expect = 9e-06, Method: Composition-based stats. Identities = 27/146 (18%), Positives = 47/146 (32%), Gaps = 39/146 (26%) Query: 68 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVIS-------------------- 107 + L + EI E FT ++ L F+ N I Sbjct: 596 KLTDLKLDYNQIEEIPEDFCAFTDQVEGLGFSHNKLKYIPNIFNAKSVYVMGSVDFSYNK 655 Query: 108 -----------DDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPK 156 D + G+ + + + N I+ F + + L+NN + ++P+ Sbjct: 656 IGSEGRNISCSMDDYKGI-NASTVTLSYNEIQKFPTELFATGSPISTIILSNNLMTSIPE 714 Query: 157 DIFKGLDS-------LTNVDLRGNSF 175 + K D LT +DLR N Sbjct: 715 NSLKPKDGNYKNTYLLTTIDLRFNKL 740 Score = 46.6 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 34/191 (17%), Positives = 59/191 (30%), Gaps = 27/191 (14%) Query: 67 PDVISLSFVRSGFTEISEG-SFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENN 125 P + + E S L LL N + +AF L L ++ N Sbjct: 548 PKIQIFYMGYNNLEEFPASASLQKMVKLGLLDCVHNKVRHL--EAFGTNVKLTDLKLDYN 605 Query: 126 NIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLV 185 I+ I + L ++N L+ +P +IF + +V + G + Sbjct: 606 QIEEIPEDFCAFTDQVEGLGFSHNKLKYIP-NIF----NAKSVYVMG-----SVDFSY-- 653 Query: 186 EWLGHTNATVEDIYCEGPPEYKKR--KINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFS 243 + +I C +YK +LS + TE + I T Sbjct: 654 ---NKIGSEGRNISCSM-DDYKGINASTVTLSYNEIQKFPTELFATGS------PISTII 703 Query: 244 YLNDEYVVIAQ 254 N+ I + Sbjct: 704 LSNNLMTSIPE 714 Score = 40.8 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 19/114 (16%), Positives = 39/114 (34%), Gaps = 13/114 (11%) Query: 69 VISLSFVRSGFTEISEGSFLF--TPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIEN-- 124 + ++ + T +S+ F P L + + N F L+ I + Sbjct: 730 LTTIDLRFNKLTSLSD-DFRATTLPYLSNMDVSYNCFSSFPTQPLNS-SQLKAFGIRHQR 787 Query: 125 ----NNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNS 174 N I SLI L + +N+++ + + + L +D+ N Sbjct: 788 DAEGNRILRQWPTGITTCPSLIQLQIGSNDIRKVDEKLTP---QLYILDIADNP 838 >5LJ5-W nrPDB Length = 238 Score = 45.4 bits (106), Expect = 7e-05, Method: Composition-based stats. Identities = 21/112 (18%), Positives = 42/112 (37%), Gaps = 11/112 (9%) Query: 46 CTCTKDNALCENARSIPRTV---PPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNS 102 C +D L ++ S+P ++ L + I + LL N+ Sbjct: 28 CVILRDLQLETDSESMPSSLKHLTKPTHILDLTNNDLIMIP--DLSRRDDIHTLLLGRNN 85 Query: 103 FDVISDDAFIGLP-HLEYLFIENNNIKSISR--HTFRGLKSLIHLSLANNNL 151 + LP +++ L + NN+I+ R ++L +L+L N + Sbjct: 86 IVEVDGRL---LPMNVQNLTLSNNSIRRFEDLQRLRRAPRTLKNLTLIGNQV 134 Score = 32.7 bits (73), Expect = 0.38, Method: Composition-based stats. Identities = 11/65 (16%), Positives = 22/65 (33%), Gaps = 5/65 (7%) Query: 65 VPPDVISLSFVRSGFTEIS-----EGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEY 119 +P +V +L+ + + +L L+ + +PHLE Sbjct: 94 LPMNVQNLTLSNNSIRRFEDLQRLRRAPRTLKNLTLIGNQVCHLANYREHVLRLVPHLET 153 Query: 120 LFIEN 124 L +N Sbjct: 154 LDFQN 158 >3G04-C nrPDB Length = 239 Score = 44.3 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 25/128 (19%), Positives = 46/128 (35%), Gaps = 30/128 (23%) Query: 46 CTCTKDN---ALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNS 102 C C ++ C++ + IP +PP Q L Sbjct: 8 CECHQEEDFRVTCKDIQRIPS-LPPST------------------------QTLKLIETH 42 Query: 103 FDVISDDAFIGLPHLEYLFIE-NNNIKSISRHTFRGLKSLIHLSLANN-NLQTLPKDIFK 160 I AF LP++ +++ + ++ + H+F L + H+ + N NL + D K Sbjct: 43 LRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALK 102 Query: 161 GLDSLTNV 168 L L + Sbjct: 103 ELPLLKFL 110 >1DCE-A nrPDB Length = 567 Score = 43.1 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 22/121 (18%), Positives = 44/121 (36%), Gaps = 7/121 (5%) Query: 66 PPDVISLSFVRSGFTEISEGSFLF-TPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIEN 124 P L +RS F + +++L V+ L + +L + + Sbjct: 416 PMRAAYLDDLRSKFL-LENSVLKMEYADVRVLHLAHKDLTVLCH--LEQLLLVTHLDLSH 472 Query: 125 NNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWL 184 N ++++ L+ L L ++N L+ + D L L + L N ++ L Sbjct: 473 NRLRALPP-ALAALRCLEVLQASDNALENV--DGVANLPRLQELLLCNNRLQQSAAIQPL 529 Query: 185 V 185 V Sbjct: 530 V 530 >1KOH-A nrPDB Length = 277 Score = 41.6 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 24/110 (21%), Positives = 42/110 (38%), Gaps = 10/110 (9%) Query: 49 TKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEG---SFLFTPSLQLLLFTSNSFDV 105 ++ + RS P V ++ V + + ++ P L L ++N Sbjct: 128 SQQALDLKGLRSDPDLV---AQNIDVVLNRRSSMAATLRIIEENIPELLSLNLSNNRLYR 184 Query: 106 ISD--DAFIGLPHLEYLFIENNNIKSISR-HTFRGLKSLIHLSLANNNLQ 152 + D P+L+ L + N +KS +GLK L L L N+L Sbjct: 185 LDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLK-LEELWLDGNSLS 233 Score = 40.0 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 19/67 (28%), Positives = 31/67 (46%), Gaps = 4/67 (5%) Query: 112 IGLPHLEYLFIENNNIKSISR--HTFRGLKSLIHLSLANNNLQTLPK-DIFKGLDSLTNV 168 +P L L + NN + + + +L L+L+ N L++ + D KGL L + Sbjct: 167 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLK-LEEL 225 Query: 169 DLRGNSF 175 L GNS Sbjct: 226 WLDGNSL 232 Score = 32.7 bits (73), Expect = 0.42, Method: Composition-based stats. Identities = 13/49 (26%), Positives = 23/49 (46%), Gaps = 2/49 (4%) Query: 136 RGLKSLIHLSLANNNLQTLPK--DIFKGLDSLTNVDLRGNSFNCDCKLK 182 + L+ L+L+NN L L I + +L ++L GN + +L Sbjct: 167 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELD 215 >4WYK-A nrPDB Length = 461 Score = 41.2 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 19/66 (28%), Positives = 28/66 (42%), Gaps = 4/66 (6%) Query: 89 FTPSLQLLLFTSNSFDVISD--DAFIGLPHLEYLFIENNNIKSISR-HTFRGLKSLIHLS 145 P L L ++N + D P+L+ L + N +KS +GLK L L Sbjct: 169 NIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLK-LEELW 227 Query: 146 LANNNL 151 L N+L Sbjct: 228 LDGNSL 233 Score = 40.8 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 21/70 (30%), Positives = 33/70 (47%), Gaps = 5/70 (7%) Query: 112 IGLPHLEYLFIENNNIKSISR--HTFRGLKSLIHLSLANNNLQTLPK-DIFKGLDSLTNV 168 +P L L + NN + + + +L L+L+ N L++ + D KGL L + Sbjct: 168 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLK-LEEL 226 Query: 169 DLRGNSFNCD 178 L GNS CD Sbjct: 227 WLDGNSL-CD 235 Score = 40.4 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 26/127 (20%), Positives = 52/127 (40%), Gaps = 22/127 (17%) Query: 67 PDVISLSFVRSGFTEISEGSF--LFTPSLQLLLFTSNSFDVISD-DAFIGLPHLEYLFIE 123 P+++SL+ + + + S P+L++L + N + D GL LE L+++ Sbjct: 171 PELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGL-KLEELWLD 229 Query: 124 NNNIKSISRHTFRGLKSLIH-----LSLANNNL-----------QTLP--KDIFKGLDSL 165 N++ R + ++ L L + L TLP K + G ++L Sbjct: 230 GNSLCDTFRDQSTYISAIRERFPKLLRLDGHELPPPIAFDVEAPTTLPPCKGSYFGTENL 289 Query: 166 TNVDLRG 172 ++ L Sbjct: 290 KSLVLHF 296 Score = 32.7 bits (73), Expect = 0.39, Method: Composition-based stats. Identities = 13/49 (26%), Positives = 23/49 (46%), Gaps = 2/49 (4%) Query: 136 RGLKSLIHLSLANNNLQTLPK--DIFKGLDSLTNVDLRGNSFNCDCKLK 182 + L+ L+L+NN L L I + +L ++L GN + +L Sbjct: 168 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELD 216 >3TSR-E nrPDB Length = 457 Score = 41.2 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 44/246 (17%), Positives = 74/246 (30%), Gaps = 43/246 (17%) Query: 30 LLTEGKKPAKPKCPAVCT----CTKDNALCENARSIPRTVPPDVISLSFVRSGFTE---- 81 LL EG + P+C C CE S+ R V D L + E Sbjct: 128 LLCEGLQ--DPQCRLEKLQLEYCNLTATSCEPLASVLR-VKADFKELVLSNNDLHEPGVR 184 Query: 82 -ISEGSFLFTPSLQLLLFTSNSFDVISD----DAFIGLPHLEYLFIENN-----NIKSIS 131 + +G L+ L + + D L+ L + +N I ++ Sbjct: 185 ILCQGLKDSACQLESLKLENCGITAANCKDLCDVVASKASLQELDLSSNKLGNAGIAALC 244 Query: 132 RHTFRGLKSLIHLSLANNNLQ----TLPKDIFKGLDSLTNVDLRGN-------SFNCD-- 178 L L L ++ + + SL + L N C+ Sbjct: 245 PGLLLPSCKLRTLWLWECDITAEGCKDLCRVLRAKQSLKELSLASNELKDEGARLLCESL 304 Query: 179 ----CKLKWLVEWLGHTNATVED--IYCEGPPEYKKRKINSLSSKDF-DCIITEFAKSQD 231 C+L+ L W+ + T +C + + +SS D + E K+ Sbjct: 305 LEPGCQLESL--WIKTCSLTAASCPYFCSVLTKSRSLLELQMSSNPLGDEGVQELCKALS 362 Query: 232 LPYQSL 237 P L Sbjct: 363 QPDTVL 368 Score = 31.2 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 19/120 (15%), Positives = 38/120 (31%), Gaps = 14/120 (11%) Query: 69 VISLSFVRSGFTEISEGSFLFT-PSLQLLLFTSNSFDVIS----DDAFIGLPHLEYLFIE 123 ++SL ++ L +++ + A P L L + Sbjct: 1 MMSLDIQCEQLSDARWTELLPLIQQYEVVRLDDCGLTEVRCKDISSAVQANPALTELSLR 60 Query: 124 NNNIKSISRH-TFRGLKS----LIHLSLANNNLQT----LPKDIFKGLDSLTNVDLRGNS 174 N + +GL++ + LSL N L + + + L +L + L N Sbjct: 61 TNELGDGGVGLVLQGLQNPTCKIQKLSLQNCGLTEAGCGILPGMLRSLSTLRELHLNDNP 120 >2BNH-A nrPDB Length = 457 Score = 40.4 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 20/101 (19%), Positives = 36/101 (35%), Gaps = 14/101 (13%) Query: 85 GSFLFTPSLQLLLFTSNSFDVISDD-AFIGLPH----LEYLFIENNNIKS----ISRHTF 135 + PSL L +N GL ++ L ++N ++ + T Sbjct: 46 SALRANPSLTELCLRTNELGDAGVHLVLQGLQSPTCKIQKLSLQNCSLTEAGCGVLPSTL 105 Query: 136 RGLKSLIHLSLANNN-----LQTLPKDIFKGLDSLTNVDLR 171 R L +L L L++N L+ L + + L + L Sbjct: 106 RSLPTLRELHLSDNPLGDAGLRLLCEGLLDPQCHLEKLQLE 146 Score = 31.6 bits (70), Expect = 0.84, Method: Composition-based stats. Identities = 18/75 (24%), Positives = 28/75 (37%), Gaps = 9/75 (12%) Query: 110 AFIGLPHLEYLFIENNNIKSISRH-TFRGLKS----LIHLSLANNNLQT----LPKDIFK 160 A P L L + N + H +GL+S + LSL N +L + + Sbjct: 47 ALRANPSLTELCLRTNELGDAGVHLVLQGLQSPTCKIQKLSLQNCSLTEAGCGVLPSTLR 106 Query: 161 GLDSLTNVDLRGNSF 175 L +L + L N Sbjct: 107 SLPTLRELHLSDNPL 121 >2Q4G-W nrPDB Length = 461 Score = 36.2 bits (82), Expect = 0.042, Method: Composition-based stats. Identities = 21/102 (20%), Positives = 36/102 (35%), Gaps = 14/102 (13%) Query: 84 EGSFLFTPSLQLLLFTSNSFDVISDD-AFIGLP----HLEYLFIENNNIKS----ISRHT 134 + P+L L SN + GL ++ L ++N + + T Sbjct: 49 SSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSST 108 Query: 135 FRGLKSLIHLSLANN-----NLQTLPKDIFKGLDSLTNVDLR 171 R L +L L L++N LQ L + + L + L Sbjct: 109 LRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150 >4PEQ-B nrPDB Length = 456 Score = 35.8 bits (81), Expect = 0.044, Method: Composition-based stats. Identities = 18/101 (17%), Positives = 33/101 (32%), Gaps = 14/101 (13%) Query: 85 GSFLFTPSLQLLLFTSNSFDVIS-DDAFIGLPH----LEYLFIENNNIKS----ISRHTF 135 + SL L +N GL ++ L ++N + + Sbjct: 45 SALQANASLTELSLRTNELGDGGVLLVLQGLQSPTCKIQKLSLQNCCLTEAGCGVLPGVL 104 Query: 136 RGLKSLIHLSLANNN-----LQTLPKDIFKGLDSLTNVDLR 171 R L +L L L++N L+ L + + L + L Sbjct: 105 RSLPTLRELHLSDNPLGDAGLRLLCEGLLDPRCRLEKLQLE 145 Score = 35.0 bits (79), Expect = 0.096, Method: Composition-based stats. Identities = 18/86 (20%), Positives = 27/86 (31%), Gaps = 11/86 (12%) Query: 91 PSLQLLLFTSNSFDVISDDAF-----IGLPHLEYLFIENNNIKSISRHTFRGL----KSL 141 L L +SN L L++ + + + S L SL Sbjct: 336 KHLLELQLSSNPLGDAGVHVLCQALGQPGTVLRVLWVGDCELTNSSCGGLASLLLASPSL 395 Query: 142 IHLSLANNNLQTLPKDIFKGLDSLTN 167 L L+NN L + + L SL Sbjct: 396 RELDLSNNGLG--DPGVLQLLGSLEQ 419 Score = 31.9 bits (71), Expect = 0.80, Method: Composition-based stats. Identities = 15/118 (12%), Positives = 31/118 (26%), Gaps = 14/118 (11%) Query: 72 LSFVRSGFTEISEGSFLFT-PSLQLLLFTSNSFDVIS----DDAFIGLPHLEYLFIENNN 126 L ++ L +++ + A L L + N Sbjct: 3 LDIQCEQLSDARWTELLPLIQQYEVVRLDDCGLTEVRCKDIGSALQANASLTELSLRTNE 62 Query: 127 IKS-----ISRHTFRGLKSLIHLSLANNNLQT----LPKDIFKGLDSLTNVDLRGNSF 175 + + + + LSL N L + + + L +L + L N Sbjct: 63 LGDGGVLLVLQGLQSPTCKIQKLSLQNCCLTEAGCGVLPGVLRSLPTLRELHLSDNPL 120 Score = 29.2 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 18/108 (16%), Positives = 29/108 (26%), Gaps = 16/108 (14%) Query: 47 TCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSL-------QLLLFT 99 +C A C + + + L S G + +L ++L Sbjct: 317 SCGFTAACC---QHFSSMLTQNKHLLELQLSSNPLGDAGVHVLCQALGQPGTVLRVLWVG 373 Query: 100 SNSFDVISDDAFIGL----PHLEYLFIENNNIKSISRHTFRGLKSLIH 143 S L P L L + NN + + L SL Sbjct: 374 DCELTNSSCGGLASLLLASPSLRELDLSNNGLG--DPGVLQLLGSLEQ 419 >1DL5-A nrPDB Length = 317 Score = 34.6 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 27/98 (27%), Positives = 40/98 (40%), Gaps = 4/98 (4%) Query: 206 YKKRKINSLSSKDFDCIITE--FAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFL 263 KK ++ +K F I E KS L Y I SY + E + + +F+ Sbjct: 9 LKKYGVSDHIAKAFLEIPREEFLTKSYPLSYVYEDIVLVSYDDGEEYSTSSQPSLMALFM 68 Query: 264 EWDHVEKTFRNYD--NITGTSTVVCKPIVIETQLYVIV 299 EW ++K R + TG + V +V E L V V Sbjct: 69 EWVGLDKGMRVLEIGGGTGYNAAVMSRVVGEKGLVVSV 106 >6MDV-A nrPDB Length = 802 Score = 34.6 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 22/106 (20%), Positives = 38/106 (35%), Gaps = 17/106 (16%) Query: 84 EGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIEN-NNIKSISRHTFR------ 136 +G L+ T + + L L+ L + +N+K I+ Sbjct: 373 KGDLERYNK--TLVLTGDKIQNL--KGLEKLSKLQKLELRQLSNVKEITPELLPESMKKD 428 Query: 137 ------GLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFN 176 G+ L L+L+ N QTL + LT+ D+ NS + Sbjct: 429 AELVMVGMTGLEKLNLSGLNRQTLDGIDVNSITHLTSFDISHNSLD 474 Score = 30.8 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 16/106 (15%), Positives = 37/106 (34%), Gaps = 11/106 (10%) Query: 56 ENARSI-PRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGL 114 N + I P +P + + +E + L+ L + + + + Sbjct: 411 SNVKEITPELLPESMK----------KDAELVMVGMTGLEKLNLSGLNRQTLDGIDVNSI 460 Query: 115 PHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFK 160 HL I +N++ + R L + ++N+ T+ F+ Sbjct: 461 THLTSFDISHNSLDLSEKSEDRKLLMTLMEQVSNHQKITVKNTAFE 506 >6J5T-G nrPDB Length = 852 Score = 33.9 bits (76), Expect = 0.20, Method: Composition-based stats. Identities = 18/94 (19%), Positives = 30/94 (31%), Gaps = 15/94 (15%) Query: 77 SGFTEISEGSFLFTPSLQLLLFTSN----SFDVISDDAFIGLPHLEYLFIENNNIKSISR 132 + F L++L + + I D+ L HL L + N + Sbjct: 545 NKLNSDLAKKFTDCKYLRVLDISKSIFDAPLSEILDEI-ASLQHLACLSLSNTH------ 597 Query: 133 HTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLT 166 + +S+ L NLQ L + L L Sbjct: 598 PLIQFPRSMEDLH----NLQILDASYCQNLKQLQ 627 Score = 30.4 bits (67), Expect = 2.3, Method: Composition-based stats. Identities = 15/73 (20%), Positives = 25/73 (34%), Gaps = 5/73 (6%) Query: 101 NSFDVISDDAFIGLPHLEYLFIENN----NIKSISRHTFRGLKSLIHLSLANNNLQTLPK 156 N + F +L L I + + I L+ L LSL+N + Sbjct: 545 NKLNSDLAKKFTDCKYLRVLDISKSIFDAPLSEILDE-IASLQHLACLSLSNTHPLIQFP 603 Query: 157 DIFKGLDSLTNVD 169 + L +L +D Sbjct: 604 RSMEDLHNLQILD 616 >2CA6-A nrPDB Length = 386 Score = 33.1 bits (74), Expect = 0.35, Method: Composition-based stats. Identities = 29/169 (17%), Positives = 58/169 (34%), Gaps = 27/169 (15%) Query: 90 TPSLQLLLFTSNSFDVISDDAFIGLPH----LEYLFIENNNIKSISRHTFRGLKSLIHLS 145 P L + + N+F + + I LE+L++ NN + + + ++L L+ Sbjct: 93 CPKLHTVRLSDNAFGPTAQEPLIDFLSKHTPLEHLYLHNNGLG--PQAGAKIARALQELA 150 Query: 146 LANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPE 205 + P L ++ N +W + H Sbjct: 151 VNKKAKNAPP---------LRSIICGRNRLENGSMKEWAKTFQSHRLL-----------H 190 Query: 206 YKKRKINSLSSKDFDCIITE-FAKSQDLPYQSLSIDTFSYLNDEYVVIA 253 K N + + + ++ E A Q+L L +TF++L + IA Sbjct: 191 TVKMVQNGIRPEGIEHLLLEGLAYCQELKVLDLQDNTFTHLGSSALAIA 239 >1JSW-A nrPDB Length = 478 Score = 33.1 bits (74), Expect = 0.36, Method: Composition-based stats. Identities = 17/56 (30%), Positives = 26/56 (46%), Gaps = 3/56 (5%) Query: 106 ISDDAFIG---LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDI 158 + DA+ G L +E +I NN I I + ++AN LQT+PK + Sbjct: 17 VPADAYYGVHTLRAIENFYISNNKISDIPEFVRGMVMVKKAAAMANKELQTIPKSV 72 >6FE8-D nrPDB Length = 519 Score = 32.7 bits (73), Expect = 0.47, Method: Composition-based stats. Identities = 24/136 (17%), Positives = 46/136 (33%), Gaps = 22/136 (16%) Query: 59 RSIPRTVPPDVISLSFVR-SGFTEISEGSFLFTPSLQLLLFTSN---SFDVIS-DDAFIG 113 ++I V + + R + + F +LQ L+ + + I F Sbjct: 300 KTISYIVKRRINEIRLSRMNQISRTGLADFTRWDNLQKLVLSRVAYIDLNSIVFPKNFKS 359 Query: 114 LP-----HLEYLFIENNNIKSI--SRHTFRGL-------KSLIHLSLANNNLQTLPKDIF 159 L +++ IE N +K + + TF+ L K +L + ++ L K Sbjct: 360 LTMKRVSKIKWWNIEENILKELKVDKRTFKSLYIKEDDSKFTKFFNLRHTRIKELDKSEI 419 Query: 160 KGLDSLTN---VDLRG 172 + L V L Sbjct: 420 NQITYLRCQAIVWLSF 435 >2P1O-B nrPDB Length = 594 Score = 32.7 bits (73), Expect = 0.48, Method: Composition-based stats. Identities = 26/144 (18%), Positives = 53/144 (36%), Gaps = 13/144 (9%) Query: 91 PSLQLLLFTSNSFDVISDDAFIGL--PHLEYLFIENNNIKSISRHTFRGLKSLIHLSLAN 148 + ++L+ +S A I +L+ L + +++ +S H + SL + Sbjct: 130 KNFKVLVLSSCEGFSTDGLAAIAATCRNLKELDLRESDVDDVSGHWLSHFPD-TYTSLVS 188 Query: 149 NNLQTLPKDI-FKGLDSL--TNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEG--- 202 N+ L ++ F L+ L +L+ N L+ L L +E++ G Sbjct: 189 LNISCLASEVSFSALERLVTRCPNLKSLKLNRAVPLEKLATLLQRA-PQLEELGTGGYTA 247 Query: 203 ---PPEYKKRKINSLSSKDFDCII 223 P Y + K+ C+ Sbjct: 248 EVRPDVYSGLSVALSGCKELRCLS 271 >5YIX-A nrPDB Length = 361 Score = 31.9 bits (71), Expect = 0.64, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 20/52 (38%), Gaps = 5/52 (9%) Query: 98 FTSNSFDVISDDAFIGLP-----HLEYLFIENNNIKSISRHTFRGLKSLIHL 144 A+ GL HL+ L + NN I+++ + K LI L Sbjct: 147 LKGEDLSDADRKAYEGLSATIIQHLKTLKLNNNRIEALVEQLYAINKRLIGL 198 >4NUY-A nrPDB Length = 899 Score = 31.6 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 22/108 (20%), Positives = 45/108 (41%), Gaps = 12/108 (11%) Query: 76 RSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYL---FIENNNIK--SI 130 + F ++++ + + L + V+ + G LE + + ++N + +I Sbjct: 401 LNKFKKLAQLDLIGLSRITKLDRS-----VLPANMKPGKDTLETVLETYKKDNKEEPATI 455 Query: 131 SRHTFR--GLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFN 176 + + GL L L L+ + +TL L SL VD+ GN + Sbjct: 456 PPVSLKVSGLTGLKELDLSGFDRETLAGLDAATLTSLEKVDISGNKLD 503 >5Y6P-24 nrPDB Length = 371 Score = 31.2 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 7/62 (11%) Query: 304 GGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWN 363 GGS I K S + KF K++++ P + TF+ NN Y V D A + I+K Sbjct: 310 GGSGI-KLQSRSGKFYKMRNM------APAKVSTFRRANNVYLVPFDELSATYIKIHKNG 362 Query: 364 GN 365 G+ Sbjct: 363 GS 364 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.313 0.135 0.403 Lambda K H 0.267 0.0416 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 22,898,774 Number of Sequences: 36641 Number of extensions: 985964 Number of successful extensions: 3548 Number of sequences better than 10.0: 71 Number of HSP's better than 10.0 without gapping: 82 Number of HSP's successfully gapped in prelim test: 43 Number of HSP's that attempted gapping in prelim test: 2106 Number of HSP's gapped (non-prelim): 504 length of query: 557 length of database: 10,336,785 effective HSP length: 102 effective length of query: 455 effective length of database: 6,599,403 effective search space: 3002728365 effective search space used: 3002728365 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 62 (28.5 bits)