BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= O95749 (300 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6C57-A nrPDB 618 e-178 2E8U-A nrPDB 223 7e-59 5ERO-A nrPDB 187 4e-48 4JXY-A nrPDB 91 9e-19 5JFQ-A nrPDB 86 2e-17 3WJN-A nrPDB 78 5e-15 4LOB-A nrPDB 77 8e-15 1WY0-A nrPDB 77 1e-14 3OYR-A nrPDB 74 9e-14 1WL1-A nrPDB 72 2e-13 5E8K-A nrPDB 70 1e-12 2FTZ-A nrPDB 69 2e-12 4JXN-A nrPDB 69 2e-12 4KKM-A nrPDB 68 4e-12 3Q2Q-A nrPDB 67 8e-12 3MZV-A nrPDB 67 1e-11 4WK5-A nrPDB 67 1e-11 3AQB-B nrPDB 64 5e-11 2Q58-A nrPDB 64 9e-11 5H9D-A nrPDB 63 1e-10 3LOM-A nrPDB 61 5e-10 5AYP-A nrPDB 60 1e-09 5E8L-A nrPDB 59 3e-09 3RMG-A nrPDB 59 3e-09 4GP1-A nrPDB 58 4e-09 3KRC-A nrPDB 58 4e-09 3AQ0-A nrPDB 57 7e-09 6B02-A nrPDB 56 2e-08 3NF2-A nrPDB 55 4e-08 1WMW-A nrPDB 55 5e-08 3IPI-A nrPDB 54 9e-08 2AZK-A nrPDB 53 1e-07 3M9U-A nrPDB 52 3e-07 5XN5-A nrPDB 52 4e-07 4LLS-A nrPDB 51 5e-07 4FP4-A nrPDB 50 9e-07 3P8R-A nrPDB 50 2e-06 3UCA-A nrPDB 50 2e-06 5E8H-A nrPDB 50 2e-06 3PKO-A nrPDB 49 2e-06 1RTR-A nrPDB 49 2e-06 2FOR-A nrPDB 49 3e-06 2J1P-A nrPDB 49 3e-06 3TC1-A nrPDB 49 4e-06 3NPK-A nrPDB 47 1e-05 5XN6-C nrPDB 45 3e-05 3ZCD-A nrPDB 45 4e-05 4F62-A nrPDB 45 5e-05 3M0G-A nrPDB 45 5e-05 3LSN-A nrPDB 43 1e-04 3P8L-A nrPDB 42 2e-04 3CP6-A nrPDB 42 4e-04 1UBV-A nrPDB 40 0.001 3TS7-A nrPDB 37 0.007 2H8O-A nrPDB 37 0.011 4LFG-A nrPDB 36 0.022 3Q1O-A nrPDB 35 0.033 2J1O-A nrPDB 32 0.22 3CT4-A nrPDB 32 0.38 3ON7-A nrPDB 32 0.40 3RBM-A nrPDB 31 0.53 1CD9-A nrPDB 31 0.61 4DOO-A nrPDB 30 0.94 3QNF-A nrPDB 30 1.0 5JOV-A nrPDB 30 1.1 3LK5-A nrPDB 30 1.2 4JZB-A nrPDB 29 2.6 3P0I-A nrPDB 28 3.2 4KK2-A nrPDB 28 4.3 1YJ8-A nrPDB 28 5.4 >6C57-A nrPDB Length = 322 Score = 618 bits (1594), Expect = e-178, Method: Compositional matrix adjust. Identities = 299/300 (99%), Positives = 299/300 (99%) Query: 1 MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS 60 MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS Sbjct: 23 MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS 82 Query: 61 LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL 120 LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL Sbjct: 83 LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL 142 Query: 121 ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL 180 ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL Sbjct: 143 ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL 202 Query: 181 GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN 240 GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN Sbjct: 203 GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN 262 Query: 241 IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE 300 IDIKK CVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE Sbjct: 263 IDIKKDCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE 322 >2E8U-A nrPDB Length = 340 Score = 223 bits (568), Expect = 7e-59, Method: Compositional matrix adjust. Identities = 121/276 (43%), Positives = 171/276 (61%), Gaps = 17/276 (6%) Query: 9 QRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIED 68 + ++ +PY ++L PGK R L N + +P+D+L I+ ++ E+LHN+SLLIDDIED Sbjct: 25 ESLISKPYNHILLKPGKNFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIED 84 Query: 69 NSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKV--LTLDHP---DAVKLFTRQLLELH 123 N+ LRRG +H I+G+PS IN+ANY+YF ++ V LT P + + +F +L+ LH Sbjct: 85 NAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLH 144 Query: 124 QGQGLDIYWRDNY--TCPTEEEYKAMVLQKTGGLFGLAVGLMQLF---SDYKEDLKPLLN 178 +GQGLDIYWRD PT+E Y MV+ KTGGLF L + LM+ S + L P +N Sbjct: 145 RGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSSHHGHSLVPFIN 204 Query: 179 TLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAI---WSRPESTQVQNILR 235 LG+ +QIRDDY NL + S K F ED+TEGK SFP +HA+ ++ ++ Q ILR Sbjct: 205 LLGIIYQIRDDYLNLKDFQMSSEKGFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILR 264 Query: 236 ---QRTENIDIKKYCVHYLE-DVGSFEYTRNTLKEL 267 RT + DIK + LE D S YT+N + +L Sbjct: 265 ILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQL 300 >5ERO-A nrPDB Length = 349 Score = 187 bits (476), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 99/276 (35%), Positives = 154/276 (55%), Gaps = 11/276 (3%) Query: 11 ILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNS 70 +L PY Y+ +P K VR + A N WL+VP+ K+ I + +LHN+SLL+DD +DNS Sbjct: 51 VLEAPYDYIASMPSKGVRDQFIDALNDWLRVPDVKVGKIKDAVRVLHNSSLLLDDFQDNS 110 Query: 71 KLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDI 130 LRRG P H+I+G +N+A Y + +++ ++V+ ++ L QGQ +D+ Sbjct: 111 PLRRGKPSTHNIFGSAQTVNTATYSIIKAIGQIMEFSAGESVQEVMNSIMILFQGQAMDL 170 Query: 131 YWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSD-------YKEDLKPLLNTLGLF 183 +W N P+EEEY M+ QKTG LF +A L+ +D + L L LG Sbjct: 171 FWTYNGHVPSEEEYYRMIDQKTGQLFSIATSLLLNAADNEIPRTKIQSCLHRLTRLLGRC 230 Query: 184 FQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNIL----RQRTE 239 FQIRDDY NL S +Y++ K FCEDL EGK+S IH I + + N+L + Sbjct: 231 FQIRDDYQNLVSADYTKQKGFCEDLDEGKWSLALIHMIHKQRSHMALLNVLSTGRKHGGM 290 Query: 240 NIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQI 275 ++ K++ + +E+ S +YTR+ + +L + +I Sbjct: 291 TLEQKQFVLDIIEEEKSLDYTRSVMMDLHVQLRAEI 326 >4JXY-A nrPDB Length = 345 Score = 90.5 bits (223), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 71/268 (26%), Positives = 127/268 (47%), Gaps = 15/268 (5%) Query: 18 YLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFP 77 Y++ GK++R L+ L + ++ + + E +H A+LL DD+ D S +RRG Sbjct: 60 YIVNSGGKRLRPLLTVLAARALNIQTEQHHTLAAIIEFIHTATLLHDDVVDESTMRRGRE 119 Query: 78 VAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYT 137 A+ ++G + + +++Y + ++TLD +++ + + +G+ L + N Sbjct: 120 TANEVFGNQASVLVGDFLYTRSFQMMVTLDSMRVMQILSDATNVIAEGEVLQL-MNCNDP 178 Query: 138 CPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNT----LGLFFQIRDDYANL 193 TEE Y ++ KT LF A L + + E ++ + LG FQ+ DD + Sbjct: 179 DTTEESYMEVIYSKTARLFEAATLLAGVLTKQSEAIENAMQDYGKYLGTAFQLVDDIMDY 238 Query: 194 HSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTE---NIDIKKYCVHY 250 S K+ +DL EGK + P ++A+W E Q I+R+ E +D + Sbjct: 239 ASDSEEMGKNMGDDLAEGKPTLPLLYAMWHGNE--QQTAIIREAIETGNGMDNLTPILET 296 Query: 251 LEDVGSFEYTRNTLKELEAKAYKQ-IDA 277 +E G+ YT K+ KA +Q IDA Sbjct: 297 MEQTGALTYT----KQQALKASQQAIDA 320 >5JFQ-A nrPDB Length = 322 Score = 85.5 bits (210), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 75/292 (25%), Positives = 132/292 (45%), Gaps = 37/292 (12%) Query: 31 LSQAFNHWLKVPEDKLQIIIEV-------------------TEMLHNASLLIDDIEDNSK 71 L +A H+LK +L+ +I + E +HN +L+ DDI D + Sbjct: 32 LYRAARHYLKAGGKRLRPVITLLSAEALGEDYRKAIHAAIAIETVHNFTLVHDDIMDEDE 91 Query: 72 LRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHP-----DAVKLFTRQLLELHQGQ 126 +RRG H+++GIP+ I + + +Y E + D P AV R +E+ +GQ Sbjct: 92 MRRGVKTVHTLFGIPTAILAGDTLYAEAFEILSMSDAPPENIVRAVSKLARVCVEICEGQ 151 Query: 127 GLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLF--- 183 +D+ + + + E EY MV +KTG L G++ + + E ++ L G++ Sbjct: 152 FMDMSFEERDSV-GESEYLEMVRKKTGVLIGISASIPAVLFGKDESVEKALWNYGIYSGI 210 Query: 184 -FQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENID 242 FQI DD ++ K K + D+ EGK + I A E +++ + R + Sbjct: 211 GFQIHDDLLDISGKGKI-GKDWGSDILEGKKTLIVIKAF---EEGIELETFGKGRASEEE 266 Query: 243 IKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPE---LVALVKHL 291 +++ + L D G+ +Y R +E A K ++ +P LV L +L Sbjct: 267 LER-DIKKLFDCGAVDYARERAREYIEMAKKNLEVIDESPSRNYLVELADYL 317 >3WJN-A nrPDB Length = 337 Score = 77.8 bits (190), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 64/278 (23%), Positives = 125/278 (44%), Gaps = 10/278 (3%) Query: 18 YLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFP 77 Y++ GK++R ++ + + I + E +H A+LL DD+ D S +RRG Sbjct: 52 YIVSGGGKRIRPMIAVLAARAVGYEGNAHVTIAALIEFIHTATLLHDDVVDESDMRRGKA 111 Query: 78 VAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYT 137 A++ +G + + +++Y + + +L +++ + + + +G+ L + N Sbjct: 112 TANAAFGNAASVLVGDFIYTRAFQMMTSLGSLKVLEVMSEAVNVIAEGEVLQLM---NVN 168 Query: 138 CP--TEEEYKAMVLQKTGGLFGLAVGLMQLFS----DYKEDLKPLLNTLGLFFQIRDDYA 191 P TEE Y ++ KT LF A + + + ++ L+ LG FQ+ DD Sbjct: 169 DPDITEENYMRVIYSKTARLFEAAAQCSGILAGCTPEEEKGLQDYGRYLGTAFQLIDDLL 228 Query: 192 NLHSKEYSENKSFCEDLTEGKFSFPTIHAI-WSRPESTQVQNILRQRTENIDIKKYCVHY 250 + ++ K+ +DL EGK + P +HA+ PE Q+ ++ + + + Sbjct: 229 DYNADGEQLGKNVGDDLNEGKPTLPLLHAMHHGTPEQAQMIRTAIEQGNGRHLLEPVLEA 288 Query: 251 LEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALV 288 + GS E+TR +E KA + P AL+ Sbjct: 289 MNACGSLEWTRQRAEEEADKAIAALQVLPDTPWREALI 326 >4LOB-A nrPDB Length = 347 Score = 77.0 bits (188), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 67/267 (25%), Positives = 127/267 (47%), Gaps = 12/267 (4%) Query: 11 ILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPE-DKLQIIIEVTEMLHNASLLIDDIEDN 69 +++ K++++ GK++R + + Q + + EMLH A+L+ DD+ D Sbjct: 56 LVMSVSKHVVEAGGKRMRPIMCLLAARACDLDNMQNAQRLAAIIEMLHTATLVHDDVVDE 115 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLD 129 S LRRG P A++ + + + +++ + ++ L++ +K F+ E+ +G+ L Sbjct: 116 SGLRRGRPTANATWNNQTAVLVGDFLIARAFDLLVDLNNMTLLKDFSTGTCEIAEGEVLQ 175 Query: 130 IYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSD---YKEDLKPLLNTLGLFFQI 186 + + + TEE Y ++ KT LF LA + + Y+E L+ G FQI Sbjct: 176 LQSQ-HQPDTTEETYLKIIHGKTSRLFELATEGAAILAGQEAYREPLRLFAGHFGNAFQI 234 Query: 187 RDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQR---TENIDI 243 DD + S + K+ +DL EGK + P I A+ ST ++ + +R T +D Sbjct: 235 IDDILDYTSDAETLGKNIGDDLMEGKPTLPLISAL---AHSTGEEHAIIRRSIATGGVDQ 291 Query: 244 KKYCVHYLEDVGSFEYT-RNTLKELEA 269 + ++ G+ +Y R +E EA Sbjct: 292 LPKVIEIVQKSGALDYCQRRAQEETEA 318 >1WY0-A nrPDB Length = 342 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 65/221 (29%), Positives = 103/221 (46%), Gaps = 14/221 (6%) Query: 10 RILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVT--EMLHNASLLIDDIE 67 R+L E ++ GK+VR + V D L+ I E++HN SL+ DDI Sbjct: 32 RVLYEAARHYPLAGGKRVRPFV--VLTSTEAVGGDPLRAIYPAVAIELIHNYSLVHDDIM 89 Query: 68 DNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL-----EL 122 D + RRG P H I+G+ I + + ++ E V + P K +++ EL Sbjct: 90 DMDETRRGKPTVHRIWGVNMAILAGDLLFSKAFEAVARAEIPPEKKARVLEVIVKASNEL 149 Query: 123 HQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLF-SDYKEDLKPLLN--- 178 +GQ D+ + T T EEY M+ KTG LF + + + +D +E +K L + Sbjct: 150 CEGQARDLEFEKKSTV-TIEEYMEMISGKTGALFEASAKVGGIIGTDNEEYIKALSSWGR 208 Query: 179 TLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIH 219 +G+ FQI DD +L + E K D+ +GK + H Sbjct: 209 NVGIAFQIWDDVLDLIADEKKLGKPVGSDIRKGKKTLIVAH 249 >3OYR-A nrPDB Length = 345 Score = 73.6 bits (179), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 97/209 (46%), Gaps = 5/209 (2%) Query: 17 KYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGF 76 ++L+ GK++R ++ A D Q + E +H A+LL DD+ D S+LRRG Sbjct: 58 EHLIAAGGKRLRPLMTVAAARLAGADNDHFQKLAAAVEFIHTATLLHDDVVDGSQLRRGK 117 Query: 77 PVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNY 136 AH I+G + ++++ E ++ + A+++ R + +G+ L + R + Sbjct: 118 VAAHLIWGGAQSVLVGDFLFARAFELMVETNSMKALEILARASRVIAEGEVLQLM-RSHD 176 Query: 137 TCPTEEEYKAMVLQKTGGLFGLA--VGLMQLFSDY--KEDLKPLLNTLGLFFQIRDDYAN 192 ++ Y ++ KT LF A G + D E L+ LGL FQ+ DD + Sbjct: 177 LNLSQAVYLEIIQAKTAELFAAASEAGAVSAGVDVAKSEALRDYGLNLGLAFQLADDALD 236 Query: 193 LHSKEYSENKSFCEDLTEGKFSFPTIHAI 221 + K+ +D EGK + P + AI Sbjct: 237 YGGATETLGKNAGDDFREGKATLPLLLAI 265 >1WL1-A nrPDB Length = 299 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 75/274 (27%), Positives = 130/274 (47%), Gaps = 19/274 (6%) Query: 1 MEKTQETVQRILLE--PYKYLLQLP--GKQVRTKLS-QAF-NHWLKVPEDKLQIIIEVTE 54 +EK +E +++IL + P + + LP GK +R +LS +F N +++ ED + + + Sbjct: 13 LEKVKERIEQILSQFFPEQIMKDLPLYGKMLRVRLSILSFKNRGVEIGEDAISSLAALEL 72 Query: 55 MLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKL 114 + + L DD+ D ++ RRG + +YG + + + + V V + + + Sbjct: 73 VALASLLH-DDVIDGARFRRGKETINFMYGDKAAVAAGDLVLVSAFHTVEEIGNNKLRRA 131 Query: 115 FTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLF-SDYKEDL 173 F + ++ + + ++ R Y T+EEY +V K+G LFGLA+ L L + EDL Sbjct: 132 FLNVIGKMSEAELIEQLSR--YKPITKEEYLRIVEGKSGALFGLALQLPALLEGELGEDL 189 Query: 174 KPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNI 233 L T+G +Q+ DD + E F DL G SFP + A+ PE+ Sbjct: 190 YNLGVTIGTIYQMFDDIMDFAGMEKIGKDGFL-DLKNGVASFPLVTAMEKFPEA------ 242 Query: 234 LRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKEL 267 RQ EN D + ++ + G + TLK L Sbjct: 243 -RQMFENRDWSG-LMSFMREKGILKECEETLKVL 274 >5E8K-A nrPDB Length = 313 Score = 69.7 bits (169), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 66/249 (26%), Positives = 104/249 (41%), Gaps = 17/249 (6%) Query: 14 EPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIE--DNSK 71 E +Y L GK+VR L A + E EMLH +SL++DD+ DN Sbjct: 41 EAMRYTLLSDGKRVRPMLCLAACELVGGQESTAMSAACAIEMLHASSLILDDLPCMDNDS 100 Query: 72 LRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDA--------VKLFTRQLLELH 123 LRRG P H ++G I ++ + L ++K + D V+ + + L Sbjct: 101 LRRGKPTNHIVFGESIAILASQALIALAVQKTTSSTFADVPPERILKTVQEMVKAVEGLV 160 Query: 124 QGQGLDIYWRD-NYTCPTEEEYKAMV-LQKTGGLFGLAV---GLMQLFSDYK-EDLKPLL 177 GQ D+ + T E+ + + KT L A +M SD + E L+ Sbjct: 161 AGQQADLAGEGMRFDSDTGLEHLEFIHIHKTAALLEAAAVMGAIMGGGSDEEIERLRSYA 220 Query: 178 NTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNI-LRQ 236 +GL FQ+ DD ++ K+ +DL GK ++P + + E + NI R+ Sbjct: 221 RCIGLMFQVVDDVLDVTKSSEELGKTAGKDLIAGKLTYPRLMGVEKSKEYAERLNIEARE 280 Query: 237 RTENIDIKK 245 DI K Sbjct: 281 HLLGFDIDK 289 >2FTZ-A nrPDB Length = 284 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 89/203 (43%), Gaps = 11/203 (5%) Query: 2 EKTQETVQRILL--------EPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVT 53 EK +E ++ IL E Y + GK++R L L V E+KL + Sbjct: 16 EKVEERIREILRPGWDLLTEEAMLYSATVGGKRIRPLLVLTLGEDLGVEEEKLLDVAVAV 75 Query: 54 EMLHNASLLIDDIE--DNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDA 111 E+ H ASL+ DD+ DN+ RRG P H YG + + + ++FL ++ + + Sbjct: 76 ELFHTASLIHDDLPPIDNADFRRGKPSCHRTYGEDIALLAGDGLFFLAFSQISKIGNSKI 135 Query: 112 VKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGL-MQLFSDYK 170 + F+ +L G+ +D+ + ++E + M KTG LF L Sbjct: 136 FEEFSETAYKLLLGEAMDVEFERRKMEVSQEMVERMYAFKTGALFAFCFSAPFILKGKDH 195 Query: 171 EDLKPLLNTLGLFFQIRDDYANL 193 +K L G+ FQI DD ++ Sbjct: 196 TKMKLLGEKFGVAFQIYDDLKDI 218 >4JXN-A nrPDB Length = 334 Score = 68.9 bits (167), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 95/213 (44%), Gaps = 7/213 (3%) Query: 14 EPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVT-EMLHNASLLIDDIEDNSKL 72 E +L++ GK++R L+ A H + I + T E +H A+LL DD+ D S Sbjct: 44 EVTAHLVEAGGKRLRPMLTLAAAHLCGY-DGPFHINLAATVEFIHTATLLHDDVVDESGQ 102 Query: 73 RRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYW 132 RRG P A+ ++ S + +Y++ + ++ + + + +G+ L + Sbjct: 103 RRGRPTANLLWDNKSSVLVGDYLFSRSFQLMVETGSLRVLDILANASATIAEGEVLQLTA 162 Query: 133 RDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLL----NTLGLFFQIRD 188 N TEE Y +V KT LF A + + + +D L + LG+ FQI D Sbjct: 163 SQNLAT-TEEVYLQVVRGKTAALFSAATEVGGVIAGAPDDHVAALFEYGDALGIAFQIVD 221 Query: 189 DYANLHSKEYSENKSFCEDLTEGKFSFPTIHAI 221 D + + K+ +D E K + P I A+ Sbjct: 222 DLLDFQGDAGAIGKNIGDDFRERKLTMPLIKAV 254 >4KKM-A nrPDB Length = 320 Score = 68.2 bits (165), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 69/278 (24%), Positives = 113/278 (40%), Gaps = 29/278 (10%) Query: 6 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDD 65 E +R L+E +Y GK++R L A V + + E +H SL+ DD Sbjct: 50 EDPRRRLVEAMRYAAIGGGKRLRPLLVVATCALFNVDREAALRVGMAIECIHVYSLIHDD 109 Query: 66 IE--DNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLE-----KVLTLDHPDAVKLFTRQ 118 + DN LRRG P H + S + S + + L E K+ T H V+L Q Sbjct: 110 MPCMDNDDLRRGKPTVHKAFDDASAVLSGDALQALAFEILSEEKIHTDPH---VRLELIQ 166 Query: 119 LLELHQG-------QGLDIYWRDN---YTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFS- 167 L + G Q +D+ + + PT + + KTG LFG + + Sbjct: 167 ALAIASGKDGMVGGQAIDLAAETSTVPFDLPTITRLQQL---KTGALFGFCLEAGAIMGR 223 Query: 168 ---DYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSR 224 D ++ LK +GL FQI DD + E K+ +D GK +F ++ + Sbjct: 224 QNKDIRDRLKAYARDIGLAFQIADDLIDAEGDEAVAGKAVGKDAAAGKATFLSL--LGLE 281 Query: 225 PESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRN 262 +Q Q ++ Q ++ + YL + + R+ Sbjct: 282 KARSQAQALVDQAIAHLSVFGSEADYLRSIARYIVARD 319 >3Q2Q-A nrPDB Length = 360 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 66/255 (25%), Positives = 119/255 (46%), Gaps = 17/255 (6%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPED----KLQIIIEVTEMLHNASLLIDDIE 67 L++ +L + GK+ R + + + + P K +++E+T H A+L DD+ Sbjct: 62 LVDIVMHLTRAGGKRFRPMFALLASEFGEKPLSENVIKAAVVVEIT---HLATLYHDDVM 118 Query: 68 DNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQG 127 D + +RRG P A++ + SV A + +++ D V F EL GQ Sbjct: 119 DEASMRRGVPSANARWD-NSVAILAGDILLAHASGLMSQLGTDTVAHFAETFGELVTGQM 177 Query: 128 LD-IYWRDNYTCPTEEEYKAMVLQKTGGLFGLA--VGLMQLFS--DYKEDLKPLLNTLGL 182 + + RD T P E Y ++ +KTG L A +G M + ++ + LK +G+ Sbjct: 178 RETVGPRD--TDPIEH-YTNVIREKTGVLIASAGYLGAMHAGAAPEHIDALKNFGAAVGM 234 Query: 183 FFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIW-SRPESTQVQNILRQRTENI 241 FQI DD ++ S+ + K+ DL EG F+ P ++A+ P ++++IL E+ Sbjct: 235 IFQIVDDIIDIFSETHESGKTPGTDLREGVFTLPVLYALREDTPVGAELRDILTGPLEDD 294 Query: 242 DIKKYCVHYLEDVGS 256 + + + L G Sbjct: 295 ETVNHVLELLSQSGG 309 >3MZV-A nrPDB Length = 341 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 57/254 (22%), Positives = 110/254 (43%), Gaps = 7/254 (2%) Query: 14 EPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLR 73 E +L++ GK++R L+ A + + E +H A+LL DD+ D S+ R Sbjct: 43 EVTAHLIEAGGKRLRPMLTLAAARLVGYGGPFHVHLAATVEFIHTATLLHDDVVDESRQR 102 Query: 74 RGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWR 133 RG P A+ ++ S + +Y++ + + + +++ + +G+ L + Sbjct: 103 RGRPTANLLWDNKSSVLVGDYLFARSFQLMTDTGNMRVMEILANASAVIAEGEVLQLTAA 162 Query: 134 DNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLL----NTLGLFFQIRDD 189 N TE+ Y ++ KT LF A + + ED L + LG+ FQI DD Sbjct: 163 QNLAT-TEDIYLRVIRGKTAALFSAATEVGGIIGGAPEDQVQALFDYGDALGIAFQIVDD 221 Query: 190 YANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQV--QNILRQRTENIDIKKYC 247 + K K+ +D E K + P I A+ E+ + + ++ + + ++ Sbjct: 222 LLDYGGKSAEIGKNTGDDFRERKLTMPVIKAVALADEAERAFWKRVIEKGDQQDGDLEHA 281 Query: 248 VHYLEDVGSFEYTR 261 + + G+ E TR Sbjct: 282 MALMTKHGTLEATR 295 >4WK5-A nrPDB Length = 294 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 47/180 (26%), Positives = 80/180 (44%), Gaps = 3/180 (1%) Query: 17 KYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIE--DNSKLRR 74 +Y + GK++R L + V E++L + E+ H ASL+ DD+ DN+ RR Sbjct: 49 QYSVTAGGKRIRPLLVLTVGEDIGVEEERLVDVAVAVELFHTASLVHDDLPPIDNADFRR 108 Query: 75 GFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRD 134 G P H YG + + + ++FL ++ + P + F+ +L G+ +D+ + Sbjct: 109 GKPSCHRAYGEGIALLAGDGLFFLAFSQIAKVREPKLFEEFSETAYKLLLGEAMDVEFER 168 Query: 135 NYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKED-LKPLLNTLGLFFQIRDDYANL 193 + E + M KTG LF L +K L G+ FQI DD ++ Sbjct: 169 QEKEISVEMVEKMYSFKTGALFAFCFSAPFLLKGLDHTFVKKLGEKFGVAFQIYDDLKDV 228 >3AQB-B nrPDB Length = 325 Score = 64.3 bits (155), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 57/216 (26%), Positives = 104/216 (48%), Gaps = 11/216 (5%) Query: 18 YLLQLPGKQVR---TKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRR 74 ++L GK+VR LS N K +D ++ + + E++H ASL+ DD DNS +RR Sbjct: 38 HILSSGGKRVRPMFVLLSGFLNDTQK--DDLIRTAVSL-ELVHMASLVHDDYIDNSDMRR 94 Query: 75 GFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRD 134 G H + + I + +++ L+ + T+++ ++F++ +LE+ G+ + R Sbjct: 95 GNTSVHIAFDKDTAIRTGHFLLARALQNIATINNSKFHQIFSKTILEVCFGEFDQMADRF 154 Query: 135 NYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKED----LKPLLNTLGLFFQIRDDY 190 NY + Y + +KT L + L L S E +K + +G+ +QI DD Sbjct: 155 NYPV-SFTAYLRRINRKTAILIEASCHLGALSSQLDEQSTYHIKQFGHCIGMSYQIIDDI 213 Query: 191 ANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPE 226 + S E + K D+ G ++P + AI + E Sbjct: 214 LDYTSDEATLGKPVGSDIRNGHITYPLMAAIANLKE 249 >2Q58-A nrPDB Length = 368 Score = 63.9 bits (154), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 72/291 (24%), Positives = 126/291 (43%), Gaps = 27/291 (9%) Query: 24 GKQVRTKL----SQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVA 79 GK +R K+ S + + + D + ++ V E + L+ DDI D+ K RRG P Sbjct: 71 GKHIRGKILVLISSLSSAYSNIKRDSIYLLGWVVEAIQALILIADDIMDSGKFRRGAPCW 130 Query: 80 HSIYGIPSVINSANYVYFLGLEKVLTLDH---PDAV----KLFTRQLLELHQGQGLDIYW 132 + ++G + IN ++ L L + L D V K++ + GQ LD+ + Sbjct: 131 YIVHGQSNAINDIFFLKMLSLSLIFELSSVFGNDIVMKIQKIYNESIFFTVLGQHLDLSY 190 Query: 133 RD-NYTCPTEEEYKAMVLQKTGG-------LFGLAVGLMQLFSDYKEDLKPLLNTLGLFF 184 D + E Y +MV KT FGL + +Q+ S ++ +L LG F+ Sbjct: 191 FDLSKADKISERYFSMVEMKTSRYTFYMPVFFGLTLSEIQVSSAQLNLIEAILYKLGEFY 250 Query: 185 QIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIK 244 Q+ +D + +Y N S +D+ K ++P + E +++ I +N + Sbjct: 251 QVHNDVS-----DYLFNDSNADDICRFKLTWPLQKSFEIADEEMKLK-ISENYGKNSSLV 304 Query: 245 KYCVHYLE-DVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKM 294 K C + L+ + EY RN L L K K I + L+ +S++ Sbjct: 305 KDCYNLLKINEHYLEYQRNALDYL-IKLVKDITDDSLQKVFIHLIHQISEL 354 >5H9D-A nrPDB Length = 319 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 72/302 (23%), Positives = 139/302 (46%), Gaps = 15/302 (4%) Query: 1 MEKTQETVQRILLEPYKYLLQLPGKQVRTK---LSQAFNHWLKVPEDKLQIIIEVTEMLH 57 +EK ++ +L + +LL GK+VR LS F + E Q+ + + E++H Sbjct: 17 LEKAIKSKDSVLEQASLHLLSSGGKRVRPAFVILSSQFGKDEQTSEQTYQVAVAL-ELIH 75 Query: 58 NASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTR 117 A+L+ DD+ D S RRG + + I + N++ LGLE ++ + +L + Sbjct: 76 MATLVHDDVIDKSDKRRGKLTISKKWDQTTAILTGNFLLALGLEHLMAVKDNRVHQLISE 135 Query: 118 QLLELHQGQGLDIYWRDNYTC-PTEEEYKAMVLQKTGGLFGLA--VGLMQLFSDYK--ED 172 ++++ +G+ ++D + T Y + +KT L ++ VG + SD + Sbjct: 136 SIVDVCRGELF--QFQDQFNSQQTIINYLRRINRKTALLIQISTEVGAITSQSDKETVRK 193 Query: 173 LKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQN 232 LK + + +G+ FQI DD + S E K DL G + P + + P+ Sbjct: 194 LKMIGHYIGMSFQIIDDVLDFTSTEKKLGKPVGSDLLNGHITLPILLEMRKNPDFKLKIE 253 Query: 233 ILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQI-DARGGNPE--LVALVK 289 LR+ +E + ++ C+ + S + + + +KA I + G+P+ L++L K Sbjct: 254 QLRRDSERKEFEE-CIQIIRKSDSIDEAKAVSSKYLSKALNLISELPDGHPKSLLLSLTK 312 Query: 290 HL 291 + Sbjct: 313 KM 314 >3LOM-A nrPDB Length = 313 Score = 61.2 bits (147), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 65/219 (29%), Positives = 98/219 (44%), Gaps = 20/219 (9%) Query: 18 YLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIE--DNSKLRRG 75 Y L GK++R L + V + L II E+ H SL+ DD+ DN LRRG Sbjct: 44 YALFSGGKRIRPILVYLAGDLIDVDQGVLDIIAAALELTHCYSLIHDDLPAMDNDDLRRG 103 Query: 76 FPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHP----DAVKLFTRQLLE------LHQG 125 P H + + I + + L +E +L P V T+ L+ + G Sbjct: 104 KPSCHKAFDEATAILVGDGMQALAIEVLLMRLSPLLPAAQVVAITQVLVNASGISGMVSG 163 Query: 126 QGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYK--EDLKPLLNT---- 179 Q LD+ + TEE+ + + L KTG L LA M L + ++ E +K L T Sbjct: 164 QSLDLSELAKSSV-TEEQLREIHLLKTGKLI-LACFEMVLAAQHEVSEQIKSALRTYGKH 221 Query: 180 LGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTI 218 +GL FQ++DDY +L++ K D K +F T+ Sbjct: 222 IGLVFQMQDDYLDLYAPTQILGKGRSSDQANQKTTFATL 260 >5AYP-A nrPDB Length = 297 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 65/252 (25%), Positives = 107/252 (42%), Gaps = 21/252 (8%) Query: 18 YLLQLPGKQVRTKLSQAFNHWL-KVPEDKLQIIIEVTEMLHNASLLIDDIE--DNSKLRR 74 Y L+ GK++R L + L K P L + + EM+H SL+ DD+ DN LRR Sbjct: 40 YSLEAGGKRIRPLLLLSTVRALGKDPAVGLPVACAI-EMIHTYSLIHDDLPSMDNDDLRR 98 Query: 75 GFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDH---PDAVKLFTRQLLE-------LHQ 124 G P H ++G I + + + + + +D P +V+L + L + Sbjct: 99 GKPTNHKVFGEAMAILAGDGLLTYAFQLITEIDDERIPPSVRLRLIERLAKAAGPEGMVA 158 Query: 125 GQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAV--GLMQLFSDYKE--DLKPLLNTL 180 GQ D+ +E EY + KTG + +V G + +D ++ +L L Sbjct: 159 GQAADMEGEGKTLTLSELEY--IHRHKTGKMLQYSVHAGALIGGADARQTRELDEFAAHL 216 Query: 181 GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQR-TE 239 GL FQIRDD ++ E K D + K ++P + ++ E QR Sbjct: 217 GLAFQIRDDILDIEGAEEKIGKPVGSDQSNNKATYPALLSLAGAKEKLAFHIEAAQRHLR 276 Query: 240 NIDIKKYCVHYL 251 N D+ + Y+ Sbjct: 277 NADVDGAALAYI 288 >5E8L-A nrPDB Length = 309 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 56/226 (24%), Positives = 89/226 (39%), Gaps = 18/226 (7%) Query: 14 EPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIE--DNSK 71 E +Y L GK+VR L A + E EM+H SL+ DD+ DN Sbjct: 35 EAMRYSLLAGGKRVRPVLCIAACELVGGEESTAMPAACAVEMIHTMSLIHDDLPCMDNDD 94 Query: 72 LRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVK--LFTRQLLELHQ----- 124 LRRG P H ++G + + + + E + + D V R + EL + Sbjct: 95 LRRGKPTNHKVFGEDVAVLAGDALLSFAFEHLASATSSDVVSPVRVVRAVGELAKAIGTE 154 Query: 125 ----GQGLDIYWRD-NYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKED----LKP 175 GQ +DI + E + + L KT L + L + +D L+ Sbjct: 155 GLVAGQVVDISSEGLDLNDVGLEHLEFIHLHKTAALLEASAVLGAIVGGGSDDEIERLRK 214 Query: 176 LLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAI 221 +GL FQ+ DD ++ K+ +DL K ++P I + Sbjct: 215 FARCIGLLFQVVDDILDVTKSSKELGKTAGKDLIADKLTYPKIMGL 260 >3RMG-A nrPDB Length = 334 Score = 58.5 bits (140), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 62/254 (24%), Positives = 120/254 (47%), Gaps = 10/254 (3%) Query: 54 EMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVK 113 E+LH ASL+ DD+ D S RRG ++I+ + + +Y+ L ++ + ++ Sbjct: 77 ELLHTASLVHDDVVDESTERRGQLSVNAIFNNKVSVLAGDYLLATSLVHAEQTNNYEIIR 136 Query: 114 LFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKED- 172 L + +L +G+ L + N++ +EE Y ++ +KT LF L E+ Sbjct: 137 LVSSLGQKLAEGELLQLSNVSNHSF-SEEVYFDVIRKKTAALFAACAEAAALSVQVGEEE 195 Query: 173 ---LKPLLNTLGLFFQIRDD-YANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPE-- 226 + L +G+ FQI+DD + SK+ K D+ EGK + P ++A+ + + Sbjct: 196 VAFARLLGEYIGICFQIKDDIFDYFDSKKI--GKPTGNDMLEGKLTLPALYALNTTKDAW 253 Query: 227 STQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVA 286 + Q+ +++ T D + + +D G EY T+++ + KA+ + A + +A Sbjct: 254 AEQIAFKVKEGTATPDEIVRLIEFTKDNGGIEYACRTIEQYKKKAFDLLAALPDSNICLA 313 Query: 287 LVKHLSKMFKEENE 300 L +L + E E Sbjct: 314 LRTYLDYVVAREKE 327 >4GP1-A nrPDB Length = 358 Score = 58.2 bits (139), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 66/268 (24%), Positives = 113/268 (42%), Gaps = 27/268 (10%) Query: 14 EPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLR 73 E Y ++ GK++R L+ A + + E++HN SL+ DDI D +R Sbjct: 35 EAVLYQVKTGGKRLRPLLTLAAAEAVSGQWRPALPAAAIVELIHNYSLIYDDIIDRGDVR 94 Query: 74 RGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLE----LHQGQGLD 129 RG P +G + I + Y +E+ + LD P LF +++ E + +G+ LD Sbjct: 95 RGLPTVRKAFGDNAAILVGIW-YREAIEEAV-LDTPKPT-LFAKEVAEVIKAIDEGERLD 151 Query: 130 I-----------YWRDNYTCPTEEEYKAMVLQKTGGLFGLAV--GLMQLFSD--YKEDLK 174 I + + + T ++Y MV KTG L A G++ + D E Sbjct: 152 ILFEAAGRSDPYFVQARWREVTLDDYIKMVSLKTGALIAAAAKWGVLSVSDDRGLAEAAW 211 Query: 175 PLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNIL 234 G+ FQI DD +++ K +D+ E K + S + + +L Sbjct: 212 NFGMAAGVAFQIIDDVLDIYGDPKKFGKEIGKDIKEHKRGNAVVAVALSHLGEGERRRLL 271 Query: 235 ----RQRTENIDIKKYCVHYLEDVGSFE 258 R+ E D+++ V L+ VG+ E Sbjct: 272 EILAREVVEEADVRE-AVALLDSVGARE 298 >3KRC-A nrPDB Length = 295 Score = 58.2 bits (139), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 56/227 (24%), Positives = 84/227 (37%), Gaps = 14/227 (6%) Query: 14 EPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIE--DNSK 71 E +Y L GK+VR L A + E EM+H SL+ DD+ DN Sbjct: 33 ESMRYSLLAGGKRVRPMLCIAACELVGGDESTAMPAACAVEMIHTMSLMHDDLPCMDNDD 92 Query: 72 LRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIY 131 LRRG P H +G + + + + E V + R L EL G + Sbjct: 93 LRRGKPTNHMAFGESVAVLAGDALLSFAFEHVAAATKGAPPERIVRVLGELAVSIGSEGL 152 Query: 132 WRDNYTCPTEEEYKAMVL--------QKTGGLFGLAVGLMQLFSDYKED----LKPLLNT 179 E + L KT L +V L + KE+ L+ N Sbjct: 153 VAGQVVDVCSEGMAEVGLDHLEFIHHHKTAALLQGSVVLGAILGGGKEEEVAKLRKFANC 212 Query: 180 LGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPE 226 +GL FQ+ DD ++ K+ +DL K ++P + + E Sbjct: 213 IGLLFQVVDDILDVTKSSKELGKTAGKDLVADKTTYPKLIGVEKSKE 259 >3AQ0-A nrPDB Length = 348 Score = 57.4 bits (137), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 49/205 (23%), Positives = 87/205 (42%), Gaps = 17/205 (8%) Query: 49 IIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDH 108 I E+TEM+H ASLL DD+ D++ RRG + + G + + +++ + L + Sbjct: 92 IAEITEMIHVASLLHDDVLDDADTRRGVGSLNVVMGNKMSVLAGDFLLSRACGALAALKN 151 Query: 109 PDAVKLFTRQLLELHQGQGLDI-------YWRDNYTCPTEEEYKAMV---LQKTGGLFGL 158 + V L + L G+ ++I Y D Y T + +++ + L G Sbjct: 152 TEVVALLATAVEHLVTGETMEITSSTAARYSMDYYMQKTYYKTASLISNSCKAVAVLTGQ 211 Query: 159 AVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTI 218 + L +Y + LGL FQ+ DD + S K D+ G + P + Sbjct: 212 TAEVAVLAFEYGRN-------LGLAFQLIDDILDFTGTSASLGKGSLSDIRHGVITAPIL 264 Query: 219 HAIWSRPESTQVQNILRQRTENIDI 243 A+ P+ +V + + N+DI Sbjct: 265 FAMEEFPQLREVVDQVAADPRNVDI 289 >6B02-A nrPDB Length = 341 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 55/191 (28%), Positives = 88/191 (46%), Gaps = 27/191 (14%) Query: 52 VTEMLHNASLLIDDIEDNSKLRRGFPVAHSI--YGIPSVINSANYVYFLGLEKVLTLDHP 109 E+L +++DDI D S RRG P + + G+ +V +S+ + F + VL Sbjct: 79 CVEILQGFLVMLDDIMDGSTTRRGVPCWYQLPEVGLAAVNDSS--LMFSSIFYVLHAHFA 136 Query: 110 DA------VKLFTRQLLELHQGQGLDIYW----RDNYTCPTEEEYKAMVLQKTG-GLFGL 158 D V+LF L+ GQ LD+ + +Y+ T E Y A+V KT + L Sbjct: 137 DKKIYTNLVELFNESLMHTSIGQHLDVTMERRQKSDYSLFTIERYNAIVKYKTAYYTYQL 196 Query: 159 AVGLMQLFSDYKEDLKPLLNT--------LGLFFQIRDDYANLHSKEYSENKSFCEDLTE 210 V L L ++ + P+L+ +G FFQI+DDY + + E S D+ E Sbjct: 197 PVCLGMLLANISD---PVLHQKAEDMCLEIGKFFQIQDDYIDCYGDE-SLTGKMGTDIQE 252 Query: 211 GKFSFPTIHAI 221 K S+ + A+ Sbjct: 253 AKCSWLAVMAL 263 >3NF2-A nrPDB Length = 352 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 68/272 (25%), Positives = 105/272 (38%), Gaps = 22/272 (8%) Query: 24 GKQVRTKLSQ-AFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSI 82 GK VR L+ + PE + + V E++HN SLL DD+ D + RR + Sbjct: 54 GKAVRPALAVLSAEVTGAAPEVGVPGAVAV-ELVHNFSLLHDDLMDGDEQRRHRDTVWKV 112 Query: 83 YGIPSVINSANYVYFLGLEKVL---TLDHPDAVKLFTRQLLELHQGQGLDIYW--RDNYT 137 +G I + ++ L E +L T++ A + T+ L GQ DI + RD + Sbjct: 113 HGPAQAILVGDALFALANEVLLELGTVEAGRATRRLTKASRSLIDGQAQDISYEHRDRVS 172 Query: 138 CPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNT----LGLFFQIRDDYANL 193 EE M KTG L A + + E L LGL FQ DD + Sbjct: 173 V---EECLEMEGNKTGALLACASSIGAVLGGADERTADTLEKYGYHLGLAFQAVDDLLGI 229 Query: 194 HSKEYSENKSFCEDLTEGKFSFPTI-HAIWSRPESTQVQNILRQRTENIDIKKYC----- 247 + K DL + K S P + S ++ IL + D + Sbjct: 230 WGDPDATGKQTWSDLRQRKKSLPVVAALAAGGAASERLGEILTADAKASDFANFSEEEFA 289 Query: 248 --VHYLEDVGSFEYTRNTLKELEAKAYKQIDA 277 +E+ G E+T + + A + +DA Sbjct: 290 ARAALIEEAGGREWTADEARRQHTIAIEALDA 321 >1WMW-A nrPDB Length = 330 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 56/176 (31%), Positives = 77/176 (43%), Gaps = 20/176 (11%) Query: 54 EMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVK 113 E+ N L+ DDIED S+ RRG P H ++ +P +N+ + ++ E L A Sbjct: 69 ELFQNWVLVHDDIEDGSEERRGRPALHRLHPMPLALNAGDAMHA---EMWGLLAEGLARG 125 Query: 114 LFTRQ-LLELHQ-------GQGLDIYWRDNYTCPTE-EEYKAMVLQKTGGLFGLAVGLMQ 164 LF + LLE H+ GQ LD+ W T E+Y MV K + AV ++ Sbjct: 126 LFPPEVLLEFHEVVRRTAYGQHLDLLWTLGGTFDLRPEDYFRMVAHKAA--YYTAVAPLR 183 Query: 165 LFSDYKEDLKPLLN-----TLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSF 215 L + P LG FQI DD NL E + K DL EGK + Sbjct: 184 LGALLAGKTPPAAYEEGGLRLGTAFQIVDDVLNLEGGE-AYGKERAGDLYEGKRTL 238 >3IPI-A nrPDB Length = 295 Score = 53.5 bits (127), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 50/199 (25%), Positives = 88/199 (44%), Gaps = 24/199 (12%) Query: 52 VTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDA 111 EM+H+ASL+ DD+ D +RR P A +G + +Y+ + K + P Sbjct: 70 AVEMMHSASLIHDDLLDQGLVRRNLPSAPEKFGPSGALLCGDYL----IAKSIAFISPYG 125 Query: 112 VKL---FTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSD 168 K+ F + +++ +G+ LD+ D E +Y + +KT LF ++ + Sbjct: 126 EKVIQDFGKAGMDMAEGEVLDLKLEDESF--GENDYFKCIYKKTASLFAISASIGAYTGG 183 Query: 169 YKEDLKPLL----NTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSR 224 +E+L N LG +QI DD L E E K E KF+ T+ I+ + Sbjct: 184 AEEELAERFSHFGNALGTAYQIVDDI--LEFLEVVEGK-------ESKFTSETLPHIYMK 234 Query: 225 PESTQVQNILRQRTENIDI 243 ST + L++ + + + Sbjct: 235 --STSKEEALKKSIDCVKL 251 >2AZK-A nrPDB Length = 289 Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 45/150 (30%), Positives = 67/150 (44%), Gaps = 11/150 (7%) Query: 54 EMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVK 113 E+LH+ASL +DDI D RRG A +YG VI NY+ L + T DA+ Sbjct: 79 EILHSASLALDDIVDLDATRRGDKAAWVVYGNRKVIFITNYLIPTALRIIQTSYGDDALN 138 Query: 114 LFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDL 173 + G D+Y +Y E KTG LF L+ L S + Sbjct: 139 TSIELEKDTSVGALRDMYDNSDYIRTIE--------LKTGSLFKLSTVLSAYASKHYNTK 190 Query: 174 KPLLNT---LGLFFQIRDDYANLHSKEYSE 200 + +L+ LG+ +Q+ DD+ + +K+ E Sbjct: 191 QQMLDVGKYLGIIYQVIDDFVDYKTKKVEE 220 >3M9U-A nrPDB Length = 309 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 64/240 (26%), Positives = 98/240 (40%), Gaps = 37/240 (15%) Query: 24 GKQVRTKLSQAFNHWLKV---PEDKLQIIIEVTEMLHNASLLIDDIE--DNSKLRRGFPV 78 GK++R L+ A L V PE + ++ + E+LH SL+ DD+ DN LRRG P Sbjct: 48 GKRLRPLLTVATMQSLGVTFVPERHWRPVMAL-ELLHTYSLIHDDLPAMDNDALRRGEPT 106 Query: 79 AHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLE-------LHQGQGLDIY 131 H +G + + + L + + D P ++ Q L + GQ DI Sbjct: 107 NHVKFGAGMATLAGDGLLTLAFQWLTATDLPATMQAALVQALATAAGPSGMVAGQAKDIQ 166 Query: 132 WRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKP----LLNTLGLFFQIR 187 ++ P + + + +KTG L AV + E P + GL FQI Sbjct: 167 -SEHVNLPLSQ-LRVLHKEKTGALLHYAVQAGLILGQAPEAQWPAYLQFADAFGLAFQIY 224 Query: 188 DDYANLHSKEYSENKSFCEDLTEGKFSFP--------------TIH----AIWSRPESTQ 229 DD ++ S K+ +D E K ++P TIH A+ P STQ Sbjct: 225 DDILDVVSSPAEMGKATQKDADEAKNTYPGKLGLIGANQALIDTIHSGQAALQGLPTSTQ 284 >5XN5-A nrPDB Length = 305 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 57/229 (24%), Positives = 90/229 (39%), Gaps = 22/229 (9%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLL--IDDIEDN 69 L E +Y L GK+VR L A + E EM+H SL+ D+ Sbjct: 33 LHEAMRYALLAGGKRVRPALCLAACAVVGGREAWAMPAAAAVEMVHTMSLVHDDLPCMDD 92 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLD----------HPDAVKLFTRQL 119 LRRG P H +YG P + + + + L + D HP V +L Sbjct: 93 DDLRRGKPTCHVVYGEPIAVLTGDALLSLSFHHMARFDSYPPDIDADKHPARVVRAIGEL 152 Query: 120 LE------LHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLF---SDYK 170 L GQ +D+ + E + + L KT L +V + + SD + Sbjct: 153 ARCIGSEGLVAGQVVDLEMTGSTETVPLERLEYIHLHKTAALLEASVVIGAILGGGSDEQ 212 Query: 171 -EDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTI 218 E L+ ++GL FQ+ DD ++ K+ +DL K ++P + Sbjct: 213 IESLRMYARSIGLLFQVVDDILDVTKSSEELGKTAGKDLASDKTTYPKL 261 >4LLS-A nrPDB Length = 311 Score = 51.2 bits (121), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 50/180 (27%), Positives = 74/180 (41%), Gaps = 18/180 (10%) Query: 54 EMLHNASLLIDDIE--DNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDA 111 E LH SL+ DD+ DN +RRG P H + + + + + + L E V HP A Sbjct: 92 EALHAYSLVHDDLPCMDNDDMRRGQPTVHKKWDDATAVLAGDALQTLAFELVT---HPGA 148 Query: 112 ---VKLFTRQLLELHQ---------GQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGL- 158 ++ L L + GQ LDI + +E + KTG L G Sbjct: 149 SASAEVRADLALSLARASGAQGMVLGQALDIAAETARAPLSLDEITRLQQGKTGALIGWS 208 Query: 159 AVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTI 218 A +L LK LGL FQI DD ++ K+ +D + GK +F ++ Sbjct: 209 AQAGARLAQADTAALKRYAQALGLAFQIADDILDVTGDSAQVGKAVGKDASAGKATFVSL 268 >4FP4-A nrPDB Length = 285 Score = 50.4 bits (119), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 49/201 (24%), Positives = 88/201 (43%), Gaps = 14/201 (6%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWL---KVPEDKLQIIIEVTEMLHNASLLIDDIED 68 L + ++ ++ PGK +R L F + + + + ++ + E+LH SLL DD+ D Sbjct: 33 LRKAVRHYIETPGKLLRPLLLLTFTYSIDRRSIMDPRILEAAAIVELLHVVSLLQDDVMD 92 Query: 69 NSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGL 128 RRG ++YG I +++++ ++ + L D V L GQ L Sbjct: 93 QHDQRRGIKTPRAMYGDGRAIVASDWLIAESIKMAVNLG-ADVVTYLADVAQRLSVGQAL 151 Query: 129 DIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAV-GLMQLFSDYKEDLKPLLNTLGLFFQIR 187 D+ + E+K L + + L + G +L E K L LG+ +Q Sbjct: 152 DLEGERDKAA----EFKTAPLIEAALVMPLVILGRRELI----ETAKKLGTKLGILYQYS 203 Query: 188 DDYANLHSKEYSENKSFCEDL 208 DDY++ + E E KS ++ Sbjct: 204 DDYSD-ENVERPETKSIANEI 223 >3P8R-A nrPDB Length = 302 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/224 (25%), Positives = 92/224 (41%), Gaps = 19/224 (8%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIE--DN 69 L+E +Y L L GK+ R L L L E +H SL+ DD+ D+ Sbjct: 38 LIEAMRYGLLLGGKRARPYLVYITGQMLGCELSDLDTPASAVECIHAYSLIHDDLPAMDD 97 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLE-------- 121 +LRRG P H + + I + + + L + D A + +L+ Sbjct: 98 DELRRGKPTCHIQFDEATAILTGDALQTLAFTILAEGDLSAAGETQRVAMLQALAEASGA 157 Query: 122 --LHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYK-EDLKPLLN 178 + GQ LD+ + + EE + + KTG L A+ L L + K + P L+ Sbjct: 158 QGMCLGQALDLAAENRLI--SLEELETIHRNKTGALMRCAIRLGALAAGEKGRAMLPHLD 215 Query: 179 ----TLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTI 218 +GL FQ++DD ++ S + K D K ++P + Sbjct: 216 RYAEAVGLAFQVQDDILDIISDTETLGKPQGSDQELNKSTYPAL 259 >3UCA-A nrPDB Length = 324 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/228 (24%), Positives = 103/228 (45%), Gaps = 17/228 (7%) Query: 9 QRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIE- 67 ++L + Y + + GK++R L + K K+ EM+H SL+ DD+ Sbjct: 59 NKVLYDSMAYSINVGGKRIRPILMLLSYYIYKSDYKKILTPAMAIEMIHTYSLIHDDLPC 118 Query: 68 -DNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVL--TLDHPDAVKLFTRQLLE--- 121 DN LRRG P H ++G + + + + ++ ++ +L+ + T+ + + Sbjct: 119 MDNDDLRRGKPTNHKVFGEAIAVLAGDALLNEAMKILVDYSLEEGKSALKATKIIADAAG 178 Query: 122 ---LHQGQGLDIYWRDNYTCPTEE-EYKAMVLQKTGGLFGLAVGLMQLFSDYKE-DLKPL 176 + GQ +DI D +E +Y M L+KTG L ++ + ++ E D+K L Sbjct: 179 SDGMIGGQIVDIINEDKEEISLKELDY--MHLKKTGELIKASIMSGAVLAEASEGDIKKL 236 Query: 177 LN---TLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAI 221 LGL FQI+DD ++ K+ +D K ++ TI + Sbjct: 237 EGFGYKLGLAFQIKDDILDVVGNAKDLGKNVHKDQESNKNNYITIFGL 284 >5E8H-A nrPDB Length = 330 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 63/243 (25%), Positives = 102/243 (41%), Gaps = 20/243 (8%) Query: 14 EPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIE--DNSK 71 E +Y L GK+VR L A + E EM+H +SL+ DD+ DN+ Sbjct: 57 EAVRYSLLAGGKRVRPLLCIAVCELVGGDEATAMSAACAVEMIHTSSLIHDDLPCMDNAD 116 Query: 72 LRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHP-DAVKLFTRQLLELHQ------ 124 LRRG P H +YG + + + + L E + + A + R ++EL + Sbjct: 117 LRRGKPTNHKVYGEDMAVLAGDALLALAFEHMTVVSSGLVAPERMIRAVVELARAIGTTG 176 Query: 125 ---GQGLDIYW-RDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKED----LKPL 176 GQ +D+ R N E + + L KT L A L + E+ L+ Sbjct: 177 LVAGQMIDLASERLNPDKVGLEHLEFIHLHKTAALLEAAAVLGVIMGGGTEEEIEKLRKY 236 Query: 177 LNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQ 236 +GL FQ+ DD ++ K+ +D+ GK ++P + + S +V LR+ Sbjct: 237 ARCIGLLFQVVDDILDVTKSTEELGKTAGKDVMAGKLTYPRLIGLE---RSKEVAEKLRR 293 Query: 237 RTE 239 E Sbjct: 294 EAE 296 >3PKO-A nrPDB Length = 334 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 49/184 (26%), Positives = 80/184 (43%), Gaps = 26/184 (14%) Query: 45 KLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVL 104 +LQ E+LH +L+ DD+ D+S RRG YG + I + ++++ + ++VL Sbjct: 77 QLQAGAAAIEILHVGTLIHDDVIDDSPTRRGVRTIQMTYGQRNAIYAGDFMFTVYFDQVL 136 Query: 105 --TLD------HPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLF 156 T D H DA+ + ELHQ +D+ +R++ T + Y + KT LF Sbjct: 137 KSTTDRSLIQNHIDAMHRILQG--ELHQ---MDLNYREDITL---DAYLNEIAGKTAELF 188 Query: 157 GLA-------VGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLT 209 L+ G Q D D+ +G +Q+ DD + K EDL Sbjct: 189 ALSCYQGAQLAGAPQSVIDRTRDIGI---AIGCAYQMLDDILDYAGDPKRTQKPVLEDLR 245 Query: 210 EGKF 213 G + Sbjct: 246 SGVY 249 >1RTR-A nrPDB Length = 301 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 49/177 (27%), Positives = 77/177 (43%), Gaps = 12/177 (6%) Query: 54 EMLHNASLLIDDIE--DNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDH-PD 110 EM+H SL+ DD+ DN RRG H +YG + I + + + E + + D D Sbjct: 72 EMIHTYSLIHDDLPAMDNDDYRRGKLTNHKVYGEWTAILAGDALLTKAFELISSDDRLTD 131 Query: 111 AVKLFTRQLLELHQGQ----GLDIYWRDNYTCPTEEEYKAMVLQ-KTGGLFGLAV----G 161 VK+ Q L + G G + + P + E M+ + KTG L AV Sbjct: 132 EVKIKVLQRLSIASGHVGMVGGQMLDMQSEGQPIDLETLEMIHKTKTGALLTFAVMSAAD 191 Query: 162 LMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTI 218 + + KE L+ LG+ FQI+DD + + E K DL K ++ ++ Sbjct: 192 IANVDDTTKEHLESYSYHLGMMFQIKDDLLDCYGDEAKLGKKVGSDLENNKSTYVSL 248 >2FOR-A nrPDB Length = 323 Score = 48.5 bits (114), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 61/269 (22%), Positives = 111/269 (41%), Gaps = 20/269 (7%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLL--IDDIEDN 69 ++E +Y L GK++R L A H V + L E +H SL+ D+ Sbjct: 56 VVETMQYGALLGGKRLRPFLVYATGHMFGVSTNTLDAPAAAVECIHAYSLIHDDLPAMDD 115 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHP-----DAVKLFT-----RQL 119 LRRG P H +G + I + + + L + + P D + + + + Sbjct: 116 DDLRRGLPTCHVKFGEANAILAGDALQTLAFSILSDANMPEVSDRDRISMISELASASGI 175 Query: 120 LELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFS-DYKEDLKPLLN 178 + GQ LD+ + P + + + KTG L AV L L + D P+L+ Sbjct: 176 AGMCGGQALDLDAEGKHV-PLDA-LERIHRHKTGALIRAAVRLGALSAGDKGRRALPVLD 233 Query: 179 ----TLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAI-WSRPESTQVQNI 233 ++GL FQ++DD ++ + K D GK ++P + + +R ++ + + Sbjct: 234 KYAESIGLAFQVQDDILDVVGDTATLGKRQGADQQLGKSTYPALLGLEQARKKARDLIDD 293 Query: 234 LRQRTENIDIKKYCVHYLEDVGSFEYTRN 262 RQ + + + LE + + RN Sbjct: 294 ARQALKQLAEQSLDTSALEALADYIIQRN 322 >2J1P-A nrPDB Length = 293 Score = 48.5 bits (114), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 52/193 (26%), Positives = 78/193 (40%), Gaps = 17/193 (8%) Query: 14 EPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIE--DNSK 71 E +Y L GK+VR L A + E EM+H SL+ DD+ DN Sbjct: 42 EAMRYSLLAGGKRVRPVLCIAACELVGGEESLAMPAACAVEMIHTMSLIHDDLPCMDNDD 101 Query: 72 LRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKL-FTRQLLELHQ------ 124 LRRG P H +YG + + + + E + + + R + EL + Sbjct: 102 LRRGKPTNHKVYGEDVAVLAGDALLSFAFEHLASATSSEVSPARVVRAVGELAKAIGTEG 161 Query: 125 ---GQGLDIYWRD-NYTCPTEEEYKAMVLQKTGGLFGLAV---GLMQLFSDYK-EDLKPL 176 GQ +DI + E K + L KT L + G++ SD + E L+ Sbjct: 162 LVAGQVVDISSEGLDLNNVGLEHLKFIHLHKTAALLEASAVLGGIIGGGSDEEIERLRKF 221 Query: 177 LNTLGLFFQIRDD 189 +GL FQ+ DD Sbjct: 222 ARCIGLLFQVVDD 234 >3TC1-A nrPDB Length = 315 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 51/207 (24%), Positives = 94/207 (45%), Gaps = 25/207 (12%) Query: 23 PGKQVRTKLSQAF--NHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAH 80 P K +R+KL A + DK + + EM+ ASLL DD+ D + +RR P + Sbjct: 34 PSKMLRSKLMLALLNEKTDAILLDKALNLCTIVEMIQTASLLHDDVIDKATMRRKLPSIN 93 Query: 81 SIYGIPSVINSANYVY---FLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYT 137 +++G + + + Y F L K+ L + + +L L +G+ D++ + + Sbjct: 94 ALFGNFNAVMLGDVFYSKAFFELSKMGEL----IAQALSNAVLRLSRGEIEDVFVGECFN 149 Query: 138 CPTEEEYKAMVLQKT-----GGLFGLAVGL---MQLFSDYKEDLKPLLNTLGLFFQIRDD 189 +++Y ++ KT L +A+ L ++++D+ LN G+ FQI DD Sbjct: 150 SD-KQKYWRILEDKTAHFIEASLKSMAILLNKDAKIYADFG------LN-FGMAFQIIDD 201 Query: 190 YANLHSKEYSENKSFCEDLTEGKFSFP 216 ++ + K D EGK + P Sbjct: 202 LLDITQDAKTLGKPNFSDFKEGKTTLP 228 >3NPK-A nrPDB Length = 291 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 55/218 (25%), Positives = 91/218 (41%), Gaps = 24/218 (11%) Query: 14 EPYKYLLQLPGKQVRTKL--SQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIE--DN 69 E +L+ GK R +L S ++ ++ L + + + E +H SL+ DD+ DN Sbjct: 29 EALALMLKAGGKHFRAQLLLSVVQSNKPELLNQALDVALAL-EFIHTYSLIHDDLPAMDN 87 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHP---DAVKL-------FTRQL 119 + RRG P H Y + I + L E L L H D +K+ F L Sbjct: 88 ADFRRGIPTLHKSYDETTAILVGDA---LNTEAFLVLSHAHLKDEIKIKLIKTLAFNAGL 144 Query: 120 LELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGL----MQLFSDYKEDLKP 175 + GQ +D ++ D E E+ + KT L A+ + +L ++ + Sbjct: 145 NGMVIGQAIDCFFEDKRLSLNELEF--LHTHKTARLIAAALKMGCEICELNNEESNQIYK 202 Query: 176 LLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKF 213 L LGL FQI DD ++ + + K D+ + F Sbjct: 203 LGLKLGLIFQINDDIIDVTTSQEQSGKPTNNDIHKNSF 240 >5XN6-C nrPDB Length = 304 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 47/183 (25%), Positives = 73/183 (39%), Gaps = 21/183 (11%) Query: 25 KQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIE--DNSKLRRGFPVAHSI 82 K+ L A L P + EMLH ASL+ DD+ D + RRG P H+ Sbjct: 50 KRAPPVLCVAACELLGAPREAALPAAVALEMLHAASLVHDDLPCFDAAPTRRGRPSTHAA 109 Query: 83 YGIPSVINSANYVYFLGLEKVLT-LDHPDAV--KLFTRQLLELHQ---------GQGLDI 130 YG + + + ++ L V+ PD V + R L EL + GQ LD+ Sbjct: 110 YGTDMAVLAGDALFPLAYTHVIAHTPSPDPVPHAVLLRVLGELARAVGSTGMAAGQFLDL 169 Query: 131 YWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLL----NTLGLFFQI 186 T E E ++ +K G + + + D + L T+G+ +Q+ Sbjct: 170 A---GATALGEAEVMKVLTKKFGEMAECSAACGAMLGGAGPDEEAALRRYGRTIGVLYQL 226 Query: 187 RDD 189 DD Sbjct: 227 VDD 229 >3ZCD-A nrPDB Length = 296 Score = 44.7 bits (104), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 56/231 (24%), Positives = 95/231 (41%), Gaps = 20/231 (8%) Query: 5 QETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLL-- 62 +E +QR L E +Y + GK+VR L+ A L + E++H SL+ Sbjct: 26 REELQR-LYEAMRYSVMNGGKRVRPLLAYAACEALGGAPQRADAAACAVELIHAYSLVHD 84 Query: 63 IDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTL-----DHPDAVKLFTR 117 D+ LRRG P H + + I +A+ + L E + +H +++ TR Sbjct: 85 DLPAMDDDDLRRGQPTTHRAFDEATAILAADGLQALAFEVLADTRRNPQEHAVCLEMLTR 144 Query: 118 QL-----LELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKE- 171 + GQ +D+ + + M KTG L +V L L S E Sbjct: 145 LARAAGSAGMVGGQAIDLGSVG--VALDQAALEVMHRHKTGALIEASVRLGALASGRAEP 202 Query: 172 ----DLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTI 218 L+ +GL FQ++DD ++ S + K+ +D K ++P + Sbjct: 203 ASLAALERYAEAIGLAFQVQDDILDVESDTATLGKTQGKDQAHNKPTYPAL 253 >4F62-A nrPDB Length = 317 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 91/217 (41%), Gaps = 17/217 (7%) Query: 17 KYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIE--DNSKLRR 74 +Y L GK++R L+ A + E +H SL+ DD+ DN +LRR Sbjct: 38 RYSLFNGGKRIRPMLTYASAQLVGDISSLTDASAAALESIHAYSLIHDDLPAMDNDELRR 97 Query: 75 GFPVAHSIYGIPSVINSANYVYFLGLEKVL--TLDHPD-AVKLFTRQLLE-----LHQGQ 126 G P H + + I + + + E + T P+ A+KL ++ + GQ Sbjct: 98 GKPTCHIQFDEATAILAGDALQTFAFELLSNPTSAQPELAIKLIQELVVASGRNGMITGQ 157 Query: 127 GLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAV--GLMQLFSDYKEDLKPL---LNTLG 181 +D+ + E E M + KTG L +V G + E L L + +G Sbjct: 158 MIDLSSENKNISLAELEQ--MHVHKTGALIKASVRMGALSTGQVKPEQLAKLDAYAHAIG 215 Query: 182 LFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTI 218 L FQ++DD +L S + K+ D K ++P + Sbjct: 216 LAFQVQDDIIDLTSDTETLGKTQFSDAEANKATYPKL 252 >3M0G-A nrPDB Length = 297 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 82/213 (38%), Gaps = 25/213 (11%) Query: 24 GKQVRTKLS--QAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIE--DNSKLRRGFPVA 79 GK++R L+ A H + + + + E LH SL+ DD+ DN LRRG P Sbjct: 41 GKRLRAFLAIESAAIHGISMAQAMPAAL--AVEALHAYSLVHDDMPCMDNDDLRRGLPTV 98 Query: 80 HSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQ-----------GQGL 128 H + + + + + + L E L D P R L GQ L Sbjct: 99 HKKWDDATAVLAGDALQTLAFE--LCTD-PVLGSAENRVALVAALAQASGAEGMVYGQAL 155 Query: 129 DIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPL---LNTLGLFFQ 185 DI T +E + KTG L A + + D PL LGL FQ Sbjct: 156 DIAAETAAVPLTLDEIIRLQAGKTGALISFAAQAGAILA--GADRGPLTAYATALGLAFQ 213 Query: 186 IRDDYANLHSKEYSENKSFCEDLTEGKFSFPTI 218 I DD ++ E + K +D K +F ++ Sbjct: 214 IADDILDVEGNEEAAGKRLGKDAEAHKATFVSL 246 >3LSN-A nrPDB Length = 304 Score = 43.1 bits (100), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 59/232 (25%), Positives = 93/232 (40%), Gaps = 19/232 (8%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLL--IDDIEDN 69 L E +Y + GK+VR L+ A L ++ E++H SL+ D+ Sbjct: 32 LYEAMRYSVMNGGKRVRPLLAYAACEALGGKPEQANGAACAVELIHAYSLVHDDLPAMDD 91 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDA-VKLFTRQLLELHQ---- 124 LRRG P H + I + + + L +L DA ++ R + L Q Sbjct: 92 DDLRRGQPTTHKAFDEACAILAGDGLQSLAFSALLDPALSDASAEIRLRMVTTLAQAAGP 151 Query: 125 -----GQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKE--DLKPL- 176 GQ +D+ EY M KTG L +V L L S E +LK L Sbjct: 152 AGMVGGQAIDLGSVGLKLDQQALEY--MHRHKTGALIEASVILGALASGRAEKGELKALQ 209 Query: 177 --LNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPE 226 +GL FQ++DD ++ S + K D+ K ++P + + + E Sbjct: 210 TYAQAIGLAFQVQDDILDVESDTATLGKRQGADIARDKPTYPALLGLAAAKE 261 >3P8L-A nrPDB Length = 302 Score = 42.4 bits (98), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 49/187 (26%), Positives = 78/187 (41%), Gaps = 15/187 (8%) Query: 54 EMLHNASLL--IDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDA 111 EM+H SL+ D+ LRRG P H ++G + I + + + + + + Sbjct: 81 EMIHTYSLIHDDLPAMDDDDLRRGKPTNHKVFGEATAILAGDGLLTGAFQLLSLSQLGLS 140 Query: 112 VK-LFTRQLLELHQGQGL------DIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQ 164 K L +QL + QG+ DI T EE A+ +KTG L A+ Sbjct: 141 EKVLLMQQLAKAAGNQGMVSGQMGDI--EGEKVSLTLEELAAVHEKKTGALIEFALIAGG 198 Query: 165 LFSDYKEDLKPLLNTL----GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHA 220 + ++ E++ LL GL FQIRDD + S E K D K ++P + Sbjct: 199 VLANQTEEVIGLLTQFAHHYGLAFQIRDDLLDATSTEADLGKKVGRDEALNKSTYPALLG 258 Query: 221 IWSRPES 227 I ++ Sbjct: 259 IAGAKDA 265 >3CP6-A nrPDB Length = 376 Score = 41.6 bits (96), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 56/201 (27%), Positives = 86/201 (42%), Gaps = 28/201 (13%) Query: 52 VTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIP-SVINSANYV--YFLGLEKVLTLDH 108 E+L L+ DDI D+S RRG + G+ IN AN + L K+ + Sbjct: 114 CVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQ 173 Query: 109 P---DAVKLFTRQLLELHQGQGLDIYWRDNYTCP---------TEEEYKAMVLQKTGGL- 155 P + ++LF + + GQ LD+ T P TE+ YK++V K Sbjct: 174 PYYLNLIELFLQSSYQTEIGQTLDLL-----TAPQGNVDLVRFTEKRYKSIVKYKAAFYS 228 Query: 156 FGLAVGL---MQLFSDYKE--DLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTE 210 F L + M KE + K +L +G FFQI+DDY +L S D+ + Sbjct: 229 FYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDP-SVTGKIGTDIQD 287 Query: 211 GKFSFPTIHAIW-SRPESTQV 230 K S+ + + + PE Q+ Sbjct: 288 NKCSWLVVQCLQRATPEQYQI 308 >1UBV-A nrPDB Length = 367 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 64/248 (25%), Positives = 106/248 (42%), Gaps = 41/248 (16%) Query: 54 EMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFL--GLEKVL---TLDH 108 E+ ASL+ DDI D S RRG + G+ +++ N + L + +VL Sbjct: 107 ELFQAASLVADDIMDQSLTRRGQLCWYKKEGVG--LDAINDSFLLESSVYRVLKKYCRQR 164 Query: 109 PDAV---KLFTRQLLELHQGQGLDIYWRDNYTCP---------TEEEYKAMVLQKTG--- 153 P V +LF + + GQ LD+ T P +EE YKA+V KT Sbjct: 165 PYYVHLLELFLQTAYQTELGQMLDL-----ITAPVSKVDLSHFSEERYKAIVKYKTAFYS 219 Query: 154 GLFGLAVGLMQLFSDYKED---LKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTE 210 +A + + D KE+ K +L +G +FQI+DDY + + + + D+ + Sbjct: 220 FYLPVAAAMYMVGIDSKEEHENAKAILLEMGEYFQIQDDYLDCFG-DPALTGAVGTDIQD 278 Query: 211 GKFSFPTIHAIWS-RPESTQV--QNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKEL 267 K S+ + + PE Q+ N R+ E + K E VG R ++ Sbjct: 279 NKCSWLVVQCLQRVTPEQRQLLEDNYGRKEPEKVAKVK---ELYEAVG----MRAAFQQY 331 Query: 268 EAKAYKQI 275 E +Y+++ Sbjct: 332 EESSYRRL 339 >3TS7-A nrPDB Length = 324 Score = 37.4 bits (85), Expect = 0.007, Method: Compositional matrix adjust. Identities = 63/262 (24%), Positives = 101/262 (38%), Gaps = 37/262 (14%) Query: 1 MEKTQETVQRIL--------------LEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKL 46 M +QE V+R L + +Y + GK++R L+ A + V D L Sbjct: 13 MRSSQERVERALDARLPAADRMPERLHQAMRYSVLGGGKRMRPLLTYATGQTIGVAADLL 72 Query: 47 QIIIEVTEMLHNASLL--IDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVL 104 E +H SL+ D+ LRRG P H Y + I + + + L VL Sbjct: 73 DGPACAVEFIHVYSLIHDDLPAMDDDDLRRGKPTCHKAYDEATAILAGDGLQALAFH-VL 131 Query: 105 TLDHPDAVKLFTR-QLLE----------LHQGQGLDIYW-RDNYTCPTEEEYKAMVLQKT 152 D AV R ++E + GQ +D+ P E M ++KT Sbjct: 132 AQDPSIAVPAENRIAMIETLAKASGPAGMVGGQAIDLASVGKKLDLPGLEN---MHIRKT 188 Query: 153 GGLFGLAVGLMQLF-----SDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCED 207 G L +V L L ++ + L +GL FQI+DD + S + K+ +D Sbjct: 189 GALIRASVRLACLARPGLPAEQFDRLDHYAKCIGLAFQIQDDILDEESDTQTLGKTRGKD 248 Query: 208 LTEGKFSFPTIHAIWSRPESTQ 229 K ++P + + E + Sbjct: 249 RDHNKPNYPALLGLSGAKEKAE 270 >2H8O-A nrPDB Length = 335 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 40/167 (23%), Positives = 68/167 (40%), Gaps = 16/167 (9%) Query: 72 LRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLEL--------- 122 LRRG P H + + I + + + L + + + D+P A + ++ L Sbjct: 135 LRRGQPTVHRKFDEATAILAGDSLLTLAFDIIASDDNPLAAERKAALVISLARAAGIGGM 194 Query: 123 HQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGL--FGLAVGLMQLFSDYKE--DLKPLLN 178 GQ LD+ P E+ + KTG L F G + S+ E L+ Sbjct: 195 AGGQALDLAAEKKA--PDEDGIITLQAMKTGALLRFACEAGAIIAGSNQAERQRLRLFGE 252 Query: 179 TLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHA-IWSR 224 +GL FQ+ DD +L + + K+ +D GK + + W+R Sbjct: 253 KIGLSFQLADDLLDLTADAATMGKATGKDAARGKGTLVALRGEAWAR 299 >4LFG-A nrPDB Length = 290 Score = 35.8 bits (81), Expect = 0.022, Method: Compositional matrix adjust. Identities = 57/247 (23%), Positives = 98/247 (39%), Gaps = 21/247 (8%) Query: 14 EPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQI-IIEVTEMLHNASLLIDDIE--DNS 70 E Y + GK++R L L++P + EM+H SL+ DD+ DN Sbjct: 28 EAVLYSINAGGKRIRPILFLEVIEALQIPLTESHFKAAAALEMIHTGSLIHDDLPAMDND 87 Query: 71 KLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKL-FTRQL------LELH 123 RRG H + + I + + ++ + D P V + R L + Sbjct: 88 DYRRGQLTNHKKFDEATAILAGDSLFLDAFGMLAETDFPTDVTVDLVRSLSSASGTFGMV 147 Query: 124 QGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGL----FGLAVGLMQLFSDYKEDLKPLLNT 179 GQ LD+ + + + KTG L F A + QL + + Sbjct: 148 GGQMLDMAAEGKKL--NLKNLQLIHRHKTGQLLAYPFWAAARVAQLDENLLATFLEIGMI 205 Query: 180 LGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSR----PES-TQVQNIL 234 +GL FQ+RDD ++ + K+ +D+ K ++P + + ES Q + IL Sbjct: 206 IGLAFQVRDDILDITANFEEIGKTPKKDVMAEKMTYPHLLGLNESYQILDESLDQAEAIL 265 Query: 235 RQRTENI 241 R+ ++ I Sbjct: 266 RKLSDEI 272 >3Q1O-A nrPDB Length = 310 Score = 35.4 bits (80), Expect = 0.033, Method: Compositional matrix adjust. Identities = 44/174 (25%), Positives = 75/174 (43%), Gaps = 16/174 (9%) Query: 54 EMLHNASLLIDDIE--DNSKLRRGFPVAHSIYGIPSVI---NSANYVYFLGLEKVLTLDH 108 E LH SL+ DD+ DN+ LRR P H+ Y + + ++ N F L L H Sbjct: 91 ECLHTYSLIHDDLPCMDNAALRRNHPTLHAKYDETTAVLIGDALNTYSFELLSNALLESH 150 Query: 109 --PDAVKLFTRQ--LLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQ 164 + +K+ + + + GQ LD Y+ + T E+ + KT L ++ + Sbjct: 151 IIVELIKILSANGGIKGMILGQALDCYFEN--TPLNLEQLTFLHEHKTAKLISASLIMGL 208 Query: 165 LFSDYKED-----LKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKF 213 + S K++ L+ +GL FQ+ DD ++ E K+ D + F Sbjct: 209 VASGIKDEELFKWLQAFGLKMGLCFQVLDDIIDVTQDEEESGKTTHLDSAKNSF 262 >2J1O-A nrPDB Length = 268 Score = 32.3 bits (72), Expect = 0.22, Method: Compositional matrix adjust. Identities = 51/187 (27%), Positives = 72/187 (38%), Gaps = 30/187 (16%) Query: 14 EPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDI--EDNSK 71 E +Y L GK+VR L A + E EM+H SL+ DD+ ED + Sbjct: 42 EAMRYSLLAGGKRVRPVLCIAACELVGGEESLAMPAACAVEMIHTMSLIHDDVYGEDVAV 101 Query: 72 LRR----GFPVAHSIYGIPSVINSANYVYFLG-LEKVLTLDHPDAVKLFTRQLLELHQGQ 126 L F H S ++ A V +G L K + + L GQ Sbjct: 102 LAGDALLSFAFEHLASATSSEVSPARVVRAVGELAKAIGTE-------------GLVAGQ 148 Query: 127 GLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAV---GLMQLFSDYK-EDLKPLLNTLGL 182 +DI N E K + L KT L + G++ SD + E L+ +GL Sbjct: 149 VVDI---SNVGL---EHLKFIHLHKTAALLEASAVLGGIIGGGSDEEIERLRKFARCIGL 202 Query: 183 FFQIRDD 189 FQ+ DD Sbjct: 203 LFQVVDD 209 >3CT4-A nrPDB Length = 332 Score = 32.0 bits (71), Expect = 0.38, Method: Compositional matrix adjust. Identities = 19/68 (27%), Positives = 31/68 (45%), Gaps = 1/68 (1%) Query: 208 LTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKEL 267 + EG S AI++ P Q+ ++ E + +YL DV +FE R + E+ Sbjct: 66 VGEGMLSAAVCGAIFTSPTPDQIYEAIKSADEGAGVLLIIKNYLGDVMNFEMARE-MAEM 124 Query: 268 EAKAYKQI 275 E +QI Sbjct: 125 EEIKVEQI 132 >3ON7-A nrPDB Length = 280 Score = 31.6 bits (70), Expect = 0.40, Method: Compositional matrix adjust. Identities = 26/83 (31%), Positives = 37/83 (44%), Gaps = 16/83 (19%) Query: 23 PGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS----------LLIDDIEDNSKL 72 PG QV+ K WL VP D III + +ML AS ++ + D +K Sbjct: 189 PGLQVKAKDGS----WLDVPSDFGNIIINIGDMLQEASDGYFPSTSHRVINPEGTDKTKS 244 Query: 73 RRGFPVAHSIYGIPSVINSANYV 95 R P+ ++ PSV+ S Y Sbjct: 245 RISLPLF--LHPHPSVVLSERYT 265 >3RBM-A nrPDB Length = 396 Score = 31.2 bits (69), Expect = 0.53, Method: Compositional matrix adjust. Identities = 49/220 (22%), Positives = 84/220 (38%), Gaps = 48/220 (21%) Query: 54 EMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFL--GLEKVLTL----- 106 E+L A L+ DDI D ++RR + + + + N+ N V L + K++ + Sbjct: 116 EILQAAFLVADDIMDKGEMRRNKYCWYLLKDVETK-NAVNDVLLLYNSIYKLIEIYLRNE 174 Query: 107 -DHPDAVKLFTRQLLELHQGQGLDI-YWRDNYTCPTEE---------------------- 142 + D + F L+ GQ LD + D Y+ E Sbjct: 175 SCYVDVIATFRDATLKTIIGQHLDTNIFSDKYSDAHREIDVNNINVPEQPVIDINMINFG 234 Query: 143 EYKAMVLQKTG----------GLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYAN 192 YK +V+ KT G+ + + L ED+ L+ G +FQI DDY + Sbjct: 235 VYKNIVIHKTAYYSFFLPIVCGMLLAGIAVDNLIYKKIEDISMLM---GEYFQIHDDYLD 291 Query: 193 LHSKEYSENKSFCEDLTEGKFSFPTIHA--IWSRPESTQV 230 + K D+ K ++P I + S P+ ++ Sbjct: 292 IFGDSTKTGK-VGSDIQNNKLTWPLIKTFELCSEPDKIKI 330 >1CD9-A nrPDB Length = 175 Score = 31.2 bits (69), Expect = 0.61, Method: Compositional matrix adjust. Identities = 26/78 (33%), Positives = 34/78 (43%), Gaps = 11/78 (14%) Query: 106 LDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVL-QKTGGLFGLAVGLMQ 164 L HP+ + L G L I W +CP++ A L Q GLF L GL+Q Sbjct: 42 LCHPEELVLL---------GHSLGIPWAPLSSCPSQALQLAGCLSQLHSGLF-LYQGLLQ 91 Query: 165 LFSDYKEDLKPLLNTLGL 182 +L P L+TL L Sbjct: 92 ALEGISPELGPTLDTLQL 109 >4DOO-A nrPDB Length = 205 Score = 30.4 bits (67), Expect = 0.94, Method: Compositional matrix adjust. Identities = 16/56 (28%), Positives = 26/56 (46%), Gaps = 1/56 (1%) Query: 186 IRDDYANLHSKEYSENKSFCEDLTEGKFSFPT-IHAIWSRPESTQVQNILRQRTEN 240 + D YANL + E NKSF +DL E + ++ + V+N ++ N Sbjct: 58 VGDKYANLPASEIRGNKSFMDDLMEADIKMTIRLQIVYGKLNIRSVRNAFQESVGN 113 >3QNF-A nrPDB Length = 954 Score = 30.4 bits (67), Expect = 1.0, Method: Compositional matrix adjust. Identities = 19/64 (29%), Positives = 33/64 (51%), Gaps = 7/64 (10%) Query: 43 EDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEK 102 ED + ++++ L + +I D E SK+ + V S+Y +P IN A+Y L+ Sbjct: 239 EDHFDVTVKMSTYL--VAFIISDFESVSKITKS-GVKVSVYAVPDKINQADY----ALDA 291 Query: 103 VLTL 106 +TL Sbjct: 292 AVTL 295 >5JOV-A nrPDB Length = 955 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 12/26 (46%), Positives = 17/26 (65%) Query: 109 PDAVKLFTRQLLELHQGQGLDIYWRD 134 PDA KLF +Q+ E + G+D +W D Sbjct: 529 PDARKLFWKQMYEHYYPLGIDAWWMD 554 >3LK5-A nrPDB Length = 380 Score = 30.0 bits (66), Expect = 1.2, Method: Compositional matrix adjust. Identities = 52/208 (25%), Positives = 77/208 (37%), Gaps = 42/208 (20%) Query: 40 KVPEDKLQIIIEVT---EMLHNASLLIDDIEDNSKLRRGFPVAH----------SIYGIP 86 K +KL+ +++ E + +L+ DDI D+S RRG P H + G P Sbjct: 81 KNSSEKLESVLDAAASLEFIQACALIHDDIIDSSDTRRGAPTVHRAVEADHRANNFEGDP 140 Query: 87 -----SVINSANYVYFLGLEKVLTLDHPDAVKLF-TRQL-----LELHQGQGLDIYWRDN 135 SV A + + E +L A L TR E+ GQ LDIY + Sbjct: 141 EHFGVSVSILAGDMALVWAEDMLQDSGLSAEALARTRDAWRGMRTEVIGGQLLDIYLESH 200 Query: 136 YTCPTE-----EEYK------AMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFF 184 E +K A L + G + L+ Y D +G+ F Sbjct: 201 ANESVELADSVNRFKTAAYTIARPLHLGASIAGGSPQLIDALLHYGHD-------IGIAF 253 Query: 185 QIRDDYANLHSKEYSENKSFCEDLTEGK 212 Q+RDD + K +D+ EGK Sbjct: 254 QLRDDLLGVFGDPAITGKPAGDDIREGK 281 >4JZB-A nrPDB Length = 362 Score = 28.9 bits (63), Expect = 2.6, Method: Compositional matrix adjust. Identities = 14/25 (56%), Positives = 16/25 (64%) Query: 54 EMLHNASLLIDDIEDNSKLRRGFPV 78 EML L+ DDI D+SK RRG P Sbjct: 88 EMLQAHFLVEDDIMDHSKTRRGKPC 112 >3P0I-A nrPDB Length = 690 Score = 28.5 bits (62), Expect = 3.2, Method: Compositional matrix adjust. Identities = 61/278 (21%), Positives = 102/278 (36%), Gaps = 44/278 (15%) Query: 22 LPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTE---MLHNASLLIDDIEDNSKLRRGFPV 78 LP + LKVP D + +I+VT+ H + + D S + Sbjct: 375 LPAAPAKPHACMWMPALLKVPLDVAEGMIKVTKDFIAAHPEGTVTLVLPDWSAV-----A 429 Query: 79 AHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYW------ 132 + I G+ I++A V L K L P +VK+ T + L D +W Sbjct: 430 SDEITGVEKDISAALQVN-CALLKAYGL--PSSVKIVTENEVILGN---CDDFWVSVIGI 483 Query: 133 -RDNYTCPTEEEYKAMVL---QKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRD 188 R N EE Y V Q L +A LM L+ + D Sbjct: 484 ARKNLLSHVEELYGGEVRNAGQVIAALMRVATALM-------------LSVSHVISTSLD 530 Query: 189 DYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKK--- 245 + N ++EY++ + C EG+ P +H + P ++L ++DI++ Sbjct: 531 GHINAFAREYTKERIDCVQTLEGR--IPALHRPGAAPAVLGADDVLYLDDNDMDIRRKIK 588 Query: 246 --YCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGN 281 Y E ++ L + A + ++ +A GGN Sbjct: 589 KAYSAPNEEANPVISVAQHLLAQHGALSIERGEANGGN 626 >4KK2-A nrPDB Length = 366 Score = 28.1 bits (61), Expect = 4.3, Method: Compositional matrix adjust. Identities = 34/154 (22%), Positives = 65/154 (42%), Gaps = 15/154 (9%) Query: 54 EMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLD------ 107 E L L++DDI D S RRG P + + + + + + ++L Sbjct: 107 EWLQAYFLVLDDIMDESHTRRGQPCWFRLPKVGMIAANDGILLRNHVPRILKKHFRGKPY 166 Query: 108 HPDAVKLFTRQLLELHQGQGLDI----YWRDNYTCPTEEEYKAMVLQKTG---GLFGLAV 160 + D V LF + GQ +D+ + + + ++ +V KT +A Sbjct: 167 YVDLVDLFNEVEFQTASGQMIDLITTLVGEKDLSKYSLSIHRRIVQYKTAYYSFYLPVAC 226 Query: 161 GLMQLFSDYKE--DLKPLLNTLGLFFQIRDDYAN 192 L+ D + ++K +L +G +FQ++DDY + Sbjct: 227 ALLMFGEDLDKHVEVKNVLVEMGTYFQVQDDYLD 260 >1YJ8-A nrPDB Length = 375 Score = 28.1 bits (61), Expect = 5.4, Method: Compositional matrix adjust. Identities = 18/61 (29%), Positives = 36/61 (59%), Gaps = 8/61 (13%) Query: 62 LIDDIEDNSKLRRGFPVAHSIYG---IPSVINSANYVYFLG----LEKVL-TLDHPDAVK 113 +I++ +N+K +G P+ H+I + SVIN A+ + F+ LE VL ++ +++K Sbjct: 71 IINNKHENTKYLKGVPLPHNIVAHSDLASVINDADLLIFIVPCQYLESVLASIKESESIK 130 Query: 114 L 114 + Sbjct: 131 I 131 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6C57-A nrPDB 371 e-103 3WJN-A nrPDB 276 1e-74 4LOB-A nrPDB 259 7e-70 3MZV-A nrPDB 255 2e-68 4JXY-A nrPDB 255 2e-68 5H9D-A nrPDB 250 4e-67 5JFQ-A nrPDB 250 6e-67 1WY0-A nrPDB 249 8e-67 5E8L-A nrPDB 249 1e-66 3KRC-A nrPDB 247 6e-66 4JXN-A nrPDB 239 1e-63 3RMG-A nrPDB 237 5e-63 5E8K-A nrPDB 234 5e-62 5AYP-A nrPDB 231 2e-61 3Q2Q-A nrPDB 231 4e-61 5ERO-A nrPDB 228 3e-60 3AQB-B nrPDB 228 3e-60 4KKM-A nrPDB 227 4e-60 2E8U-A nrPDB 225 2e-59 3OYR-A nrPDB 225 2e-59 2J1P-A nrPDB 224 4e-59 4F62-A nrPDB 223 7e-59 3P8R-A nrPDB 220 5e-58 2FOR-A nrPDB 220 8e-58 4WK5-A nrPDB 219 1e-57 2FTZ-A nrPDB 219 1e-57 3UCA-A nrPDB 212 1e-55 5E8H-A nrPDB 211 3e-55 3ZCD-A nrPDB 210 4e-55 5XN5-A nrPDB 210 7e-55 4GP1-A nrPDB 209 1e-54 3LSN-A nrPDB 208 3e-54 3NF2-A nrPDB 207 4e-54 4LLS-A nrPDB 200 4e-52 3M9U-A nrPDB 199 2e-51 1RTR-A nrPDB 199 2e-51 2Q58-A nrPDB 194 3e-50 3M0G-A nrPDB 194 5e-50 3LOM-A nrPDB 192 2e-49 3AQ0-A nrPDB 186 1e-47 1WL1-A nrPDB 185 2e-47 3TC1-A nrPDB 184 5e-47 3P8L-A nrPDB 183 8e-47 3NPK-A nrPDB 181 3e-46 3IPI-A nrPDB 174 4e-44 1UBV-A nrPDB 170 6e-43 6B02-A nrPDB 163 6e-41 1WMW-A nrPDB 162 2e-40 3PKO-A nrPDB 161 3e-40 5XN6-C nrPDB 155 2e-38 3CP6-A nrPDB 148 2e-36 4FP4-A nrPDB 141 4e-34 2AZK-A nrPDB 130 6e-31 Sequences not found previously or not previously below threshold: 3TS7-A nrPDB 205 2e-53 4LFG-A nrPDB 182 2e-46 2J1O-A nrPDB 178 3e-45 3Q1O-A nrPDB 173 7e-44 2H8O-A nrPDB 167 5e-42 3LK5-A nrPDB 148 2e-36 4KK2-A nrPDB 143 7e-35 3RBM-A nrPDB 135 2e-32 5AHU-B nrPDB 119 2e-27 5AEL-A nrPDB 118 3e-27 3ICK-A nrPDB 116 9e-27 4JZB-A nrPDB 115 2e-26 3KRO-B nrPDB 63 1e-10 3QKC-B nrPDB 56 2e-08 3QD2-B nrPDB 33 0.21 4M7I-A nrPDB 32 0.38 5H05-A nrPDB 30 1.0 4FYU-A nrPDB 28 4.5 >6C57-A nrPDB Length = 322 Score = 371 bits (954), Expect = e-103, Method: Composition-based stats. Identities = 299/300 (99%), Positives = 299/300 (99%) Query: 1 MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS 60 MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS Sbjct: 23 MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS 82 Query: 61 LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL 120 LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL Sbjct: 83 LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL 142 Query: 121 ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL 180 ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL Sbjct: 143 ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL 202 Query: 181 GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN 240 GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN Sbjct: 203 GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN 262 Query: 241 IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE 300 IDIKK CVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE Sbjct: 263 IDIKKDCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE 322 >3WJN-A nrPDB Length = 337 Score = 276 bits (705), Expect = 1e-74, Method: Composition-based stats. Identities = 63/276 (22%), Positives = 123/276 (44%), Gaps = 6/276 (2%) Query: 18 YLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFP 77 Y++ GK++R ++ + + I + E +H A+LL DD+ D S +RRG Sbjct: 52 YIVSGGGKRIRPMIAVLAARAVGYEGNAHVTIAALIEFIHTATLLHDDVVDESDMRRGKA 111 Query: 78 VAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYT 137 A++ +G + + +++Y + + +L +++ + + + +G+ L + N Sbjct: 112 TANAAFGNAASVLVGDFIYTRAFQMMTSLGSLKVLEVMSEAVNVIAEGEVLQL-MNVNDP 170 Query: 138 CPTEEEYKAMVLQKTGGLFGLAVGLMQLFSD----YKEDLKPLLNTLGLFFQIRDDYANL 193 TEE Y ++ KT LF A + + ++ L+ LG FQ+ DD + Sbjct: 171 DITEENYMRVIYSKTARLFEAAAQCSGILAGCTPEEEKGLQDYGRYLGTAFQLIDDLLDY 230 Query: 194 HSKEYSENKSFCEDLTEGKFSFPTIHAI-WSRPESTQVQNILRQRTENIDIKKYCVHYLE 252 ++ K+ +DL EGK + P +HA+ PE Q+ ++ + + + + Sbjct: 231 NADGEQLGKNVGDDLNEGKPTLPLLHAMHHGTPEQAQMIRTAIEQGNGRHLLEPVLEAMN 290 Query: 253 DVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALV 288 GS E+TR +E KA + P AL+ Sbjct: 291 ACGSLEWTRQRAEEEADKAIAALQVLPDTPWREALI 326 >4LOB-A nrPDB Length = 347 Score = 259 bits (663), Expect = 7e-70, Method: Composition-based stats. Identities = 64/283 (22%), Positives = 124/283 (43%), Gaps = 5/283 (1%) Query: 11 ILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPE-DKLQIIIEVTEMLHNASLLIDDIEDN 69 +++ K++++ GK++R + + Q + + EMLH A+L+ DD+ D Sbjct: 56 LVMSVSKHVVEAGGKRMRPIMCLLAARACDLDNMQNAQRLAAIIEMLHTATLVHDDVVDE 115 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLD 129 S LRRG P A++ + + + +++ + ++ L++ +K F+ E+ +G+ L Sbjct: 116 SGLRRGRPTANATWNNQTAVLVGDFLIARAFDLLVDLNNMTLLKDFSTGTCEIAEGEVLQ 175 Query: 130 IYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYK---EDLKPLLNTLGLFFQI 186 + + + TEE Y ++ KT LF LA + + + E L+ G FQI Sbjct: 176 LQSQ-HQPDTTEETYLKIIHGKTSRLFELATEGAAILAGQEAYREPLRLFAGHFGNAFQI 234 Query: 187 RDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKY 246 DD + S + K+ +DL EGK + P I A+ T +D Sbjct: 235 IDDILDYTSDAETLGKNIGDDLMEGKPTLPLISALAHSTGEEHAIIRRSIATGGVDQLPK 294 Query: 247 CVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVK 289 + ++ G+ +Y + +E A + + P AL+ Sbjct: 295 VIEIVQKSGALDYCQRRAQEETEAALQALSILPDTPYRQALIN 337 >3MZV-A nrPDB Length = 341 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 63/305 (20%), Positives = 122/305 (40%), Gaps = 7/305 (2%) Query: 2 EKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASL 61 E+ + E +L++ GK++R L+ A + + E +H A+L Sbjct: 31 ERMSSEHAPRIPEVTAHLIEAGGKRLRPMLTLAAARLVGYGGPFHVHLAATVEFIHTATL 90 Query: 62 LIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLE 121 L DD+ D S+ RRG P A+ ++ S + +Y++ + + + +++ Sbjct: 91 LHDDVVDESRQRRGRPTANLLWDNKSSVLVGDYLFARSFQLMTDTGNMRVMEILANASAV 150 Query: 122 LHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKED----LKPLL 177 + +G+ L + N TE+ Y ++ KT LF A + + ED L Sbjct: 151 IAEGEVLQLTAAQNL-ATTEDIYLRVIRGKTAALFSAATEVGGIIGGAPEDQVQALFDYG 209 Query: 178 NTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQV--QNILR 235 + LG+ FQI DD + K K+ +D E K + P I A+ E+ + + ++ Sbjct: 210 DALGIAFQIVDDLLDYGGKSAEIGKNTGDDFRERKLTMPVIKAVALADEAERAFWKRVIE 269 Query: 236 QRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF 295 + + ++ + + G+ E TR A K + +P L + Sbjct: 270 KGDQQDGDLEHAMALMTKHGTLEATRLAAIGWTDTARKALAKLPDHPLRQMLDDLADYVV 329 Query: 296 KEENE 300 + E Sbjct: 330 ERVRE 334 >4JXY-A nrPDB Length = 345 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 64/276 (23%), Positives = 123/276 (44%), Gaps = 6/276 (2%) Query: 18 YLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFP 77 Y++ GK++R L+ L + ++ + + E +H A+LL DD+ D S +RRG Sbjct: 60 YIVNSGGKRLRPLLTVLAARALNIQTEQHHTLAAIIEFIHTATLLHDDVVDESTMRRGRE 119 Query: 78 VAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYT 137 A+ ++G + + +++Y + ++TLD +++ + + +G+ L + N Sbjct: 120 TANEVFGNQASVLVGDFLYTRSFQMMVTLDSMRVMQILSDATNVIAEGEVLQL-MNCNDP 178 Query: 138 CPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKP----LLNTLGLFFQIRDDYANL 193 TEE Y ++ KT LF A L + + E ++ LG FQ+ DD + Sbjct: 179 DTTEESYMEVIYSKTARLFEAATLLAGVLTKQSEAIENAMQDYGKYLGTAFQLVDDIMDY 238 Query: 194 HSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPE-STQVQNILRQRTENIDIKKYCVHYLE 252 S K+ +DL EGK + P ++A+W E T + + +D + +E Sbjct: 239 ASDSEEMGKNMGDDLAEGKPTLPLLYAMWHGNEQQTAIIREAIETGNGMDNLTPILETME 298 Query: 253 DVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALV 288 G+ YT+ + +A + + AL+ Sbjct: 299 QTGALTYTKQQALKASQQAIDALSPIEESVYKEALI 334 >5H9D-A nrPDB Length = 319 Score = 250 bits (639), Expect = 4e-67, Method: Composition-based stats. Identities = 65/300 (21%), Positives = 133/300 (44%), Gaps = 11/300 (3%) Query: 1 MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPE--DKLQIIIEVTEMLHN 58 +EK ++ +L + +LL GK+VR + + K + ++ + E++H Sbjct: 17 LEKAIKSKDSVLEQASLHLLSSGGKRVRPAFVILSSQFGKDEQTSEQTYQVAVALELIHM 76 Query: 59 ASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQ 118 A+L+ DD+ D S RRG + + I + N++ LGLE ++ + +L + Sbjct: 77 ATLVHDDVIDKSDKRRGKLTISKKWDQTTAILTGNFLLALGLEHLMAVKDNRVHQLISES 136 Query: 119 LLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYK----EDLK 174 ++++ +G+ + N + T Y + +KT L ++ + + S LK Sbjct: 137 IVDVCRGELFQFQDQFN-SQQTIINYLRRINRKTALLIQISTEVGAITSQSDKETVRKLK 195 Query: 175 PLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNIL 234 + + +G+ FQI DD + S E K DL G + P + + P+ L Sbjct: 196 MIGHYIGMSFQIIDDVLDFTSTEKKLGKPVGSDLLNGHITLPILLEMRKNPDFKLKIEQL 255 Query: 235 RQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQI-DARGGNPE--LVALVKHL 291 R+ +E + ++ C+ + S + + + +KA I + G+P+ L++L K + Sbjct: 256 RRDSERKEFEE-CIQIIRKSDSIDEAKAVSSKYLSKALNLISELPDGHPKSLLLSLTKKM 314 >5JFQ-A nrPDB Length = 322 Score = 250 bits (638), Expect = 6e-67, Method: Composition-based stats. Identities = 75/307 (24%), Positives = 137/307 (44%), Gaps = 15/307 (4%) Query: 2 EKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASL 61 E +E L ++ L+ GK++R ++ L K E +HN +L Sbjct: 22 ELLKEQEPEGLYRAARHYLKAGGKRLRPVITLLSAEALGEDYRKAIHAAIAIETVHNFTL 81 Query: 62 LIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHP-----DAVKLFT 116 + DDI D ++RRG H+++GIP+ I + + +Y E + D P AV Sbjct: 82 VHDDIMDEDEMRRGVKTVHTLFGIPTAILAGDTLYAEAFEILSMSDAPPENIVRAVSKLA 141 Query: 117 RQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPL 176 R +E+ +GQ +D+ + + + E EY MV +KTG L G++ + + E ++ Sbjct: 142 RVCVEICEGQFMDMSFEERDS-VGESEYLEMVRKKTGVLIGISASIPAVLFGKDESVEKA 200 Query: 177 LNTLGLF----FQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQN 232 L G++ FQI DD ++ K K + D+ EGK + I A E +++ Sbjct: 201 LWNYGIYSGIGFQIHDDLLDISGKGK-IGKDWGSDILEGKKTLIVIKAFE---EGIELET 256 Query: 233 ILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLS 292 + R ++ + + L D G+ +Y R +E A K ++ +P LV+ Sbjct: 257 FGKGRASEEEL-ERDIKKLFDCGAVDYARERAREYIEMAKKNLEVIDESPSRNYLVELAD 315 Query: 293 KMFKEEN 299 + + ++ Sbjct: 316 YLIERDH 322 >1WY0-A nrPDB Length = 342 Score = 249 bits (637), Expect = 8e-67, Method: Composition-based stats. Identities = 74/320 (23%), Positives = 130/320 (40%), Gaps = 23/320 (7%) Query: 1 MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS 60 E E R+L E ++ GK+VR + + + E++HN S Sbjct: 23 FELIPEKDPRVLYEAARHYPLAGGKRVRPFVVLTSTEAVGGDPLRAIYPAVAIELIHNYS 82 Query: 61 LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHP-----DAVKLF 115 L+ DDI D + RRG P H I+G+ I + + ++ E V + P +++ Sbjct: 83 LVHDDIMDMDETRRGKPTVHRIWGVNMAILAGDLLFSKAFEAVARAEIPPEKKARVLEVI 142 Query: 116 TRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFS-DYKEDLK 174 + EL +GQ D+ + + T EEY M+ KTG LF + + + D +E +K Sbjct: 143 VKASNELCEGQARDLEFE-KKSTVTIEEYMEMISGKTGALFEASAKVGGIIGTDNEEYIK 201 Query: 175 PL---LNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQ 231 L +G+ FQI DD +L + E K D+ +GK + H + E + + Sbjct: 202 ALSSWGRNVGIAFQIWDDVLDLIADEKKLGKPVGSDIRKGKKTLIVAHFFENADEKDKQR 261 Query: 232 ----------NILRQRTENIDIKKYCVH---YLEDVGSFEYTRNTLKELEAKAYKQIDAR 278 ++ + DIK + L+ GS +Y K++ KA + + Sbjct: 262 FLKIFGKYAGDVKGRGIIEEDIKSDVMEAIDLLKKYGSIDYAAEIAKDMIKKANEALRIL 321 Query: 279 GGNPELVALVKHLSKMFKEE 298 + + L + + E Sbjct: 322 PKSKARMDLELLAKFIVERE 341 >5E8L-A nrPDB Length = 309 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 61/253 (24%), Positives = 97/253 (38%), Gaps = 19/253 (7%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDI--EDN 69 + E +Y L GK+VR L A + E EM+H SL+ DD+ DN Sbjct: 33 IHEAMRYSLLAGGKRVRPVLCIAACELVGGEESTAMPAACAVEMIHTMSLIHDDLPCMDN 92 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVK--LFTRQLLELH---- 123 LRRG P H ++G + + + + E + + D V R + EL Sbjct: 93 DDLRRGKPTNHKVFGEDVAVLAGDALLSFAFEHLASATSSDVVSPVRVVRAVGELAKAIG 152 Query: 124 -----QGQGLDIYWRD-NYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFS----DYKEDL 173 GQ +DI + E + + L KT L + L + D E L Sbjct: 153 TEGLVAGQVVDISSEGLDLNDVGLEHLEFIHLHKTAALLEASAVLGAIVGGGSDDEIERL 212 Query: 174 KPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPE-STQVQN 232 + +GL FQ+ DD ++ K+ +DL K ++P I + E + ++ Sbjct: 213 RKFARCIGLLFQVVDDILDVTKSSKELGKTAGKDLIADKLTYPKIMGLEKSREFAEKLNR 272 Query: 233 ILRQRTENIDIKK 245 R + D K Sbjct: 273 EARDQLLGFDSDK 285 >3KRC-A nrPDB Length = 295 Score = 247 bits (630), Expect = 6e-66, Method: Composition-based stats. Identities = 58/241 (24%), Positives = 90/241 (37%), Gaps = 16/241 (6%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDI--EDN 69 + E +Y L GK+VR L A + E EM+H SL+ DD+ DN Sbjct: 31 IHESMRYSLLAGGKRVRPMLCIAACELVGGDESTAMPAACAVEMIHTMSLMHDDLPCMDN 90 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQ----- 124 LRRG P H +G + + + + E V + R L EL Sbjct: 91 DDLRRGKPTNHMAFGESVAVLAGDALLSFAFEHVAAATKGAPPERIVRVLGELAVSIGSE 150 Query: 125 ----GQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKED----LKPL 176 GQ +D+ + + + KT L +V L + KE+ L+ Sbjct: 151 GLVAGQVVDVCSEG-MAEVGLDHLEFIHHHKTAALLQGSVVLGAILGGGKEEEVAKLRKF 209 Query: 177 LNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQ 236 N +GL FQ+ DD ++ K+ +DL K ++P + + E N Q Sbjct: 210 ANCIGLLFQVVDDILDVTKSSKELGKTAGKDLVADKTTYPKLIGVEKSKEFADRLNREAQ 269 Query: 237 R 237 Sbjct: 270 E 270 >4JXN-A nrPDB Length = 334 Score = 239 bits (609), Expect = 1e-63, Method: Composition-based stats. Identities = 61/292 (20%), Positives = 114/292 (39%), Gaps = 7/292 (2%) Query: 14 EPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLR 73 E +L++ GK++R L+ A H + E +H A+LL DD+ D S R Sbjct: 44 EVTAHLVEAGGKRLRPMLTLAAAHLCGYDGPFHINLAATVEFIHTATLLHDDVVDESGQR 103 Query: 74 RGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWR 133 RG P A+ ++ S + +Y++ + ++ + + + +G+ L + Sbjct: 104 RGRPTANLLWDNKSSVLVGDYLFSRSFQLMVETGSLRVLDILANASATIAEGEVLQLTAS 163 Query: 134 DNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKED----LKPLLNTLGLFFQIRDD 189 N TEE Y +V KT LF A + + + +D L + LG+ FQI DD Sbjct: 164 QNL-ATTEEVYLQVVRGKTAALFSAATEVGGVIAGAPDDHVAALFEYGDALGIAFQIVDD 222 Query: 190 YANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQV--QNILRQRTENIDIKKYC 247 + + K+ +D E K + P I A+ + + + + ++ Sbjct: 223 LLDFQGDAGAIGKNIGDDFRERKLTMPLIKAVAKADAEERAFWVRTIEKGKQEEGDLQHA 282 Query: 248 VHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEEN 299 + L + T + A+A + +P LV + + N Sbjct: 283 IALLHKHAALTDTSVVARTQAARAKAALAPLPAHPVKDMLVDLADYVVERIN 334 >3RMG-A nrPDB Length = 334 Score = 237 bits (604), Expect = 5e-63, Method: Composition-based stats. Identities = 65/300 (21%), Positives = 127/300 (42%), Gaps = 8/300 (2%) Query: 7 TVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDI 66 +L ++ + GK +R L E+LH ASL+ DD+ Sbjct: 30 DSNALLDSVITHIRKRNGKMMRPILVLLVARLYGAVTPATLHAAVSLELLHTASLVHDDV 89 Query: 67 EDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQ 126 D S RRG ++I+ + + +Y+ L ++ + ++L + +L +G+ Sbjct: 90 VDESTERRGQLSVNAIFNNKVSVLAGDYLLATSLVHAEQTNNYEIIRLVSSLGQKLAEGE 149 Query: 127 GLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKED----LKPLLNTLGL 182 L + N++ +EE Y ++ +KT LF L E+ + L +G+ Sbjct: 150 LLQLSNVSNHSF-SEEVYFDVIRKKTAALFAACAEAAALSVQVGEEEVAFARLLGEYIGI 208 Query: 183 FFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPE--STQVQNILRQRTEN 240 FQI+DD + K D+ EGK + P ++A+ + + + Q+ +++ T Sbjct: 209 CFQIKDDIFDYF-DSKKIGKPTGNDMLEGKLTLPALYALNTTKDAWAEQIAFKVKEGTAT 267 Query: 241 IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE 300 D + + +D G EY T+++ + KA+ + A + +AL +L + E E Sbjct: 268 PDEIVRLIEFTKDNGGIEYACRTIEQYKKKAFDLLAALPDSNICLALRTYLDYVVAREKE 327 >5E8K-A nrPDB Length = 313 Score = 234 bits (596), Expect = 5e-62, Method: Composition-based stats. Identities = 62/257 (24%), Positives = 102/257 (39%), Gaps = 17/257 (6%) Query: 6 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDD 65 + + E +Y L GK+VR L A + E EMLH +SL++DD Sbjct: 33 REPELKIREAMRYTLLSDGKRVRPMLCLAACELVGGQESTAMSAACAIEMLHASSLILDD 92 Query: 66 I--EDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDA--------VKLF 115 + DN LRRG P H ++G I ++ + L ++K + D V+ Sbjct: 93 LPCMDNDSLRRGKPTNHIVFGESIAILASQALIALAVQKTTSSTFADVPPERILKTVQEM 152 Query: 116 TRQLLELHQGQGLDIYWRD--NYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYK--- 170 + + L GQ D+ + E + + + KT L A + + Sbjct: 153 VKAVEGLVAGQQADLAGEGMRFDSDTGLEHLEFIHIHKTAALLEAAAVMGAIMGGGSDEE 212 Query: 171 -EDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQ 229 E L+ +GL FQ+ DD ++ K+ +DL GK ++P + + E + Sbjct: 213 IERLRSYARCIGLMFQVVDDVLDVTKSSEELGKTAGKDLIAGKLTYPRLMGVEKSKEYAE 272 Query: 230 VQNI-LRQRTENIDIKK 245 NI R+ DI K Sbjct: 273 RLNIEAREHLLGFDIDK 289 >5AYP-A nrPDB Length = 297 Score = 231 bits (590), Expect = 2e-61, Method: Composition-based stats. Identities = 57/270 (21%), Positives = 101/270 (37%), Gaps = 21/270 (7%) Query: 1 MEKTQETVQ--RILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHN 58 + + E ++ L + Y L+ GK++R L + L + EM+H Sbjct: 21 LSRYIERLEGPAKLKKAMAYSLEAGGKRIRPLLLLSTVRALGKDPAVGLPVACAIEMIHT 80 Query: 59 ASLLIDDI--EDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDA----- 111 SL+ DD+ DN LRRG P H ++G I + + + + + +D Sbjct: 81 YSLIHDDLPSMDNDDLRRGKPTNHKVFGEAMAILAGDGLLTYAFQLITEIDDERIPPSVR 140 Query: 112 ---VKLFTRQLL--ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLF 166 ++ + + GQ D+ +E EY + KTG + +V L Sbjct: 141 LRLIERLAKAAGPEGMVAGQAADMEGEGKTLTLSELEY--IHRHKTGKMLQYSVHAGALI 198 Query: 167 SDYK----EDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIW 222 +L LGL FQIRDD ++ E K D + K ++P + ++ Sbjct: 199 GGADARQTRELDEFAAHLGLAFQIRDDILDIEGAEEKIGKPVGSDQSNNKATYPALLSLA 258 Query: 223 SRPESTQ-VQNILRQRTENIDIKKYCVHYL 251 E ++ N D+ + Y+ Sbjct: 259 GAKEKLAFHIEAAQRHLRNADVDGAALAYI 288 >3Q2Q-A nrPDB Length = 360 Score = 231 bits (588), Expect = 4e-61, Method: Composition-based stats. Identities = 65/298 (21%), Positives = 123/298 (41%), Gaps = 9/298 (3%) Query: 9 QRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVP-EDKLQIIIEVTEMLHNASLLIDDIE 67 + L++ +L + GK+ R + + + + P + + V E+ H A+L DD+ Sbjct: 59 EDFLVDIVMHLTRAGGKRFRPMFALLASEFGEKPLSENVIKAAVVVEITHLATLYHDDVM 118 Query: 68 DNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQG 127 D + +RRG P A++ + I + + + + L D V F EL GQ Sbjct: 119 DEASMRRGVPSANARWDNSVAILAGDILLAHASGLMSQLG-TDTVAHFAETFGELVTGQM 177 Query: 128 LDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSD----YKEDLKPLLNTLGLF 183 + E Y ++ +KTG L A L + + + + LK +G+ Sbjct: 178 RE--TVGPRDTDPIEHYTNVIREKTGVLIASAGYLGAMHAGAAPEHIDALKNFGAAVGMI 235 Query: 184 FQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAI-WSRPESTQVQNILRQRTENID 242 FQI DD ++ S+ + K+ DL EG F+ P ++A+ P ++++IL E+ + Sbjct: 236 FQIVDDIIDIFSETHESGKTPGTDLREGVFTLPVLYALREDTPVGAELRDILTGPLEDDE 295 Query: 243 IKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE 300 + + L G + + + A ++D + AL + K E Sbjct: 296 TVNHVLELLSQSGGRQAALDEVYRYMDIANAELDRLPDSTVKEALRNLATFTVKRVGE 353 >5ERO-A nrPDB Length = 349 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 99/276 (35%), Positives = 154/276 (55%), Gaps = 11/276 (3%) Query: 11 ILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNS 70 +L PY Y+ +P K VR + A N WL+VP+ K+ I + +LHN+SLL+DD +DNS Sbjct: 51 VLEAPYDYIASMPSKGVRDQFIDALNDWLRVPDVKVGKIKDAVRVLHNSSLLLDDFQDNS 110 Query: 71 KLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDI 130 LRRG P H+I+G +N+A Y + +++ ++V+ ++ L QGQ +D+ Sbjct: 111 PLRRGKPSTHNIFGSAQTVNTATYSIIKAIGQIMEFSAGESVQEVMNSIMILFQGQAMDL 170 Query: 131 YWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSD-------YKEDLKPLLNTLGLF 183 +W N P+EEEY M+ QKTG LF +A L+ +D + L L LG Sbjct: 171 FWTYNGHVPSEEEYYRMIDQKTGQLFSIATSLLLNAADNEIPRTKIQSCLHRLTRLLGRC 230 Query: 184 FQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNIL----RQRTE 239 FQIRDDY NL S +Y++ K FCEDL EGK+S IH I + + N+L + Sbjct: 231 FQIRDDYQNLVSADYTKQKGFCEDLDEGKWSLALIHMIHKQRSHMALLNVLSTGRKHGGM 290 Query: 240 NIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQI 275 ++ K++ + +E+ S +YTR+ + +L + +I Sbjct: 291 TLEQKQFVLDIIEEEKSLDYTRSVMMDLHVQLRAEI 326 >3AQB-B nrPDB Length = 325 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 65/305 (21%), Positives = 131/305 (42%), Gaps = 10/305 (3%) Query: 1 MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS 60 + + ++ + + ++L GK+VR +D L E++H AS Sbjct: 21 LYECIQSDSETINKAAHHILSSGGKRVRPMFVLLSGFLNDTQKDDLIRTAVSLELVHMAS 80 Query: 61 LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL 120 L+ DD DNS +RRG H + + I + +++ L+ + T+++ ++F++ +L Sbjct: 81 LVHDDYIDNSDMRRGNTSVHIAFDKDTAIRTGHFLLARALQNIATINNSKFHQIFSKTIL 140 Query: 121 ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKED----LKPL 176 E+ G+ + R NY + Y + +KT L + L L S E +K Sbjct: 141 EVCFGEFDQMADRFNY-PVSFTAYLRRINRKTAILIEASCHLGALSSQLDEQSTYHIKQF 199 Query: 177 LNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPES--TQVQNIL 234 + +G+ +QI DD + S E + K D+ G ++P + AI + E +++ ++ Sbjct: 200 GHCIGMSYQIIDDILDYTSDEATLGKPVGSDIRNGHITYPLMAAIANLKEQDDDKLEAVV 259 Query: 235 RQ--RTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLS 292 + T + ++ +Y V ++ G E ++ KA + + L + Sbjct: 260 KHLTSTSDDEVYQYIVSQVKQYG-IEPAELLSRKYGDKAKYHLSQLQDSNIKDYLEEIHE 318 Query: 293 KMFKE 297 KM K Sbjct: 319 KMLKR 323 >4KKM-A nrPDB Length = 320 Score = 227 bits (580), Expect = 4e-60, Method: Composition-based stats. Identities = 59/274 (21%), Positives = 103/274 (37%), Gaps = 17/274 (6%) Query: 4 TQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLI 63 E +R L+E +Y GK++R L A V + + E +H SL+ Sbjct: 48 VPEDPRRRLVEAMRYAAIGGGKRLRPLLVVATCALFNVDREAALRVGMAIECIHVYSLIH 107 Query: 64 DDI--EDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLD-------HPDAVKL 114 DD+ DN LRRG P H + S + S + + L E + + ++ Sbjct: 108 DDMPCMDNDDLRRGKPTVHKAFDDASAVLSGDALQALAFEILSEEKIHTDPHVRLELIQA 167 Query: 115 FTRQLLE--LHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFS----D 168 + + GQ +D+ + + KTG LFG + + D Sbjct: 168 LAIASGKDGMVGGQAIDLAAETSTVPFDLPTITRLQQLKTGALFGFCLEAGAIMGRQNKD 227 Query: 169 YKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPEST 228 ++ LK +GL FQI DD + E K+ +D GK +F ++ + Sbjct: 228 IRDRLKAYARDIGLAFQIADDLIDAEGDEAVAGKAVGKDAAAGKATFLSLLGLEKARSQA 287 Query: 229 QVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRN 262 Q ++ Q ++ + YL + + R+ Sbjct: 288 Q--ALVDQAIAHLSVFGSEADYLRSIARYIVARD 319 >2E8U-A nrPDB Length = 340 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 125/316 (39%), Positives = 180/316 (56%), Gaps = 30/316 (9%) Query: 9 QRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIED 68 + ++ +PY ++L PGK R L N + +P+D+L I+ ++ E+LHN+SLLIDDIED Sbjct: 25 ESLISKPYNHILLKPGKNFRLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIED 84 Query: 69 NSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDA-----VKLFTRQLLELH 123 N+ LRRG +H I+G+PS IN+ANY+YF ++ V L + + +F +L+ LH Sbjct: 85 NAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLH 144 Query: 124 QGQGLDIYWRDNYTC--PTEEEYKAMVLQKTGGLFGLAVGLMQLF---SDYKEDLKPLLN 178 +GQGLDIYWRD PT+E Y MV+ KTGGLF L + LM+ S + L P +N Sbjct: 145 RGQGLDIYWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSSHHGHSLVPFIN 204 Query: 179 TLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRP---ESTQVQNILR 235 LG+ +QIRDDY NL + S K F ED+TEGK SFP +HA+ ++ Q ILR Sbjct: 205 LLGIIYQIRDDYLNLKDFQMSSEKGFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILR 264 Query: 236 ---QRTENIDIKKYCVHYLE-DVGSFEYTRNTLKELEAKAYKQID-------------AR 278 RT + DIK + LE D S YT+N + +L + A Sbjct: 265 ILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKNDNENKYLPDLASHSDTAT 324 Query: 279 GGNPELVALVKHLSKM 294 + EL+ ++ HLS++ Sbjct: 325 NLHDELLYIIDHLSEL 340 >3OYR-A nrPDB Length = 345 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 62/287 (21%), Positives = 118/287 (41%), Gaps = 7/287 (2%) Query: 17 KYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGF 76 ++L+ GK++R ++ A D Q + E +H A+LL DD+ D S+LRRG Sbjct: 58 EHLIAAGGKRLRPLMTVAAARLAGADNDHFQKLAAAVEFIHTATLLHDDVVDGSQLRRGK 117 Query: 77 PVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNY 136 AH I+G + ++++ E ++ + A+++ R + +G+ L + R + Sbjct: 118 VAAHLIWGGAQSVLVGDFLFARAFELMVETNSMKALEILARASRVIAEGEVLQL-MRSHD 176 Query: 137 TCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSD----YKEDLKPLLNTLGLFFQIRDDYAN 192 ++ Y ++ KT LF A + + E L+ LGL FQ+ DD + Sbjct: 177 LNLSQAVYLEIIQAKTAELFAAASEAGAVSAGVDVAKSEALRDYGLNLGLAFQLADDALD 236 Query: 193 LHSKEYSENKSFCEDLTEGKFSFPTIHAIWSR--PESTQVQNILRQRTENIDIKKYCVHY 250 + K+ +D EGK + P + AI E+ + + +R + + Sbjct: 237 YGGATETLGKNAGDDFREGKATLPLLLAIARSGPREAEFWERAIGRREQTEADFRRAREL 296 Query: 251 LEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKE 297 + G+ + T + + KA + N AL + Sbjct: 297 IIGSGALDATLDLAADYADKAKAALAMFPANDWREALEELADFAVSR 343 >2J1P-A nrPDB Length = 293 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 54/243 (22%), Positives = 86/243 (35%), Gaps = 31/243 (12%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDI--EDN 69 + E +Y L GK+VR L A + E EM+H SL+ DD+ DN Sbjct: 40 IHEAMRYSLLAGGKRVRPVLCIAACELVGGEESLAMPAACAVEMIHTMSLIHDDLPCMDN 99 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHP--------DAVKLFTRQLL- 120 LRRG P H +YG + + + + E + + AV + + Sbjct: 100 DDLRRGKPTNHKVYGEDVAVLAGDALLSFAFEHLASATSSEVSPARVVRAVGELAKAIGT 159 Query: 121 -ELHQGQGLDIYWRD-NYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYK----EDLK 174 L GQ +DI + E K + L KT L + L + E L+ Sbjct: 160 EGLVAGQVVDISSEGLDLNNVGLEHLKFIHLHKTAALLEASAVLGGIIGGGSDEEIERLR 219 Query: 175 PLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNIL 234 +GL FQ+ DD ++ K ++P + + E + N Sbjct: 220 KFARCIGLLFQVVDDILDVTKSS--------------KLTYPKLMGLEKSREFAEKLNTE 265 Query: 235 RQR 237 + Sbjct: 266 ARD 268 >4F62-A nrPDB Length = 317 Score = 223 bits (569), Expect = 7e-59, Method: Composition-based stats. Identities = 59/271 (21%), Positives = 104/271 (38%), Gaps = 19/271 (7%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDI--EDN 69 L +Y L GK++R L+ A + E +H SL+ DD+ DN Sbjct: 33 LHNAMRYSLFNGGKRIRPMLTYASAQLVGDISSLTDASAAALESIHAYSLIHDDLPAMDN 92 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPD---AVKLFTRQLL-----E 121 +LRRG P H + + I + + + E + A+KL ++ Sbjct: 93 DELRRGKPTCHIQFDEATAILAGDALQTFAFELLSNPTSAQPELAIKLIQELVVASGRNG 152 Query: 122 LHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKE-----DLKPL 176 + GQ +D+ + + E + M + KTG L +V + L + + L Sbjct: 153 MITGQMIDLSSENK--NISLAELEQMHVHKTGALIKASVRMGALSTGQVKPEQLAKLDAY 210 Query: 177 LNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQ 236 + +GL FQ++DD +L S + K+ D K ++P + + V + Q Sbjct: 211 AHAIGLAFQVQDDIIDLTSDTETLGKTQFSDAEANKATYPKLLGLDGAK--ALVVRLHEQ 268 Query: 237 RTENIDIKKYCVHYLEDVGSFEYTRNTLKEL 267 I L D+ ++ RN + L Sbjct: 269 AIAQISEFGDKSQPLTDLANYIIDRNHAENL 299 >3P8R-A nrPDB Length = 302 Score = 220 bits (562), Expect = 5e-58, Method: Composition-based stats. Identities = 54/234 (23%), Positives = 88/234 (37%), Gaps = 19/234 (8%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDI--EDN 69 L+E +Y L L GK+ R L L L E +H SL+ DD+ D+ Sbjct: 38 LIEAMRYGLLLGGKRARPYLVYITGQMLGCELSDLDTPASAVECIHAYSLIHDDLPAMDD 97 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVK----------LFTRQL 119 +LRRG P H + + I + + + L + D A + Sbjct: 98 DELRRGKPTCHIQFDEATAILTGDALQTLAFTILAEGDLSAAGETQRVAMLQALAEASGA 157 Query: 120 LELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKED-----LK 174 + GQ LD+ + + EE + + KTG L A+ L L + K L Sbjct: 158 QGMCLGQALDLAAENRLI--SLEELETIHRNKTGALMRCAIRLGALAAGEKGRAMLPHLD 215 Query: 175 PLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPEST 228 +GL FQ++DD ++ S + K D K ++P + + + Sbjct: 216 RYAEAVGLAFQVQDDILDIISDTETLGKPQGSDQELNKSTYPALLGLEGAQQKA 269 >2FOR-A nrPDB Length = 323 Score = 220 bits (560), Expect = 8e-58, Method: Composition-based stats. Identities = 58/269 (21%), Positives = 104/269 (38%), Gaps = 20/269 (7%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLI--DDIEDN 69 ++E +Y L GK++R L A H V + L E +H SL+ D+ Sbjct: 56 VVETMQYGALLGGKRLRPFLVYATGHMFGVSTNTLDAPAAAVECIHAYSLIHDDLPAMDD 115 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKL----------FTRQL 119 LRRG P H +G + I + + + L + + P+ + Sbjct: 116 DDLRRGLPTCHVKFGEANAILAGDALQTLAFSILSDANMPEVSDRDRISMISELASASGI 175 Query: 120 LELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKED-----LK 174 + GQ LD+ + + + + KTG L AV L L + K L Sbjct: 176 AGMCGGQALDLDAEGKHVPL--DALERIHRHKTGALIRAAVRLGALSAGDKGRRALPVLD 233 Query: 175 PLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIW-SRPESTQVQNI 233 ++GL FQ++DD ++ + K D GK ++P + + +R ++ + + Sbjct: 234 KYAESIGLAFQVQDDILDVVGDTATLGKRQGADQQLGKSTYPALLGLEQARKKARDLIDD 293 Query: 234 LRQRTENIDIKKYCVHYLEDVGSFEYTRN 262 RQ + + + LE + + RN Sbjct: 294 ARQALKQLAEQSLDTSALEALADYIIQRN 322 >4WK5-A nrPDB Length = 294 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 53/263 (20%), Positives = 97/263 (36%), Gaps = 5/263 (1%) Query: 2 EKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASL 61 E + + +Y + GK++R L + V E++L + E+ H ASL Sbjct: 34 ELVKPHFNLLTESAMQYSVTAGGKRIRPLLVLTVGEDIGVEEERLVDVAVAVELFHTASL 93 Query: 62 LIDDIE--DNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQL 119 + DD+ DN+ RRG P H YG + + + ++FL ++ + P + F+ Sbjct: 94 VHDDLPPIDNADFRRGKPSCHRAYGEGIALLAGDGLFFLAFSQIAKVREPKLFEEFSETA 153 Query: 120 LELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKED-LKPLLN 178 +L G+ +D+ + + E + M KTG LF L +K L Sbjct: 154 YKLLLGEAMDVEFERQEKEISVEMVEKMYSFKTGALFAFCFSAPFLLKGLDHTFVKKLGE 213 Query: 179 TLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRT 238 G+ FQI DD ++ K +D+ K + + + Sbjct: 214 KFGVAFQIYDDLKDVLGSLEKLGKDVGKDVK--KVTLVKKMGVQKAKQLADKYYEEVLEA 271 Query: 239 ENIDIKKYCVHYLEDVGSFEYTR 261 + +L ++ R Sbjct: 272 LESEGLHRTFDFLRNLKKMVEER 294 >2FTZ-A nrPDB Length = 284 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 58/240 (24%), Positives = 96/240 (40%), Gaps = 13/240 (5%) Query: 2 EKTQETVQRILL--------EPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVT 53 EK +E ++ IL E Y + GK++R L L V E+KL + Sbjct: 16 EKVEERIREILRPGWDLLTEEAMLYSATVGGKRIRPLLVLTLGEDLGVEEEKLLDVAVAV 75 Query: 54 EMLHNASLLIDDIE--DNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDA 111 E+ H ASL+ DD+ DN+ RRG P H YG + + + ++FL ++ + + Sbjct: 76 ELFHTASLIHDDLPPIDNADFRRGKPSCHRTYGEDIALLAGDGLFFLAFSQISKIGNSKI 135 Query: 112 VKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKE 171 + F+ +L G+ +D+ + ++E + M KTG LF + Sbjct: 136 FEEFSETAYKLLLGEAMDVEFERRKMEVSQEMVERMYAFKTGALFAFCFSAPFILKGKDH 195 Query: 172 -DLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQV 230 +K L G+ FQI DD ++ K +D K + I E Sbjct: 196 TKMKLLGEKFGVAFQIYDDLKDILGSFEKVGKDLGKDTE--KVTLVKKVGIQKAREMADK 253 >3UCA-A nrPDB Length = 324 Score = 212 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 56/265 (21%), Positives = 105/265 (39%), Gaps = 27/265 (10%) Query: 6 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDD 65 ++L + Y + + GK++R L + K K+ EM+H SL+ DD Sbjct: 56 REYNKVLYDSMAYSINVGGKRIRPILMLLSYYIYKSDYKKILTPAMAIEMIHTYSLIHDD 115 Query: 66 I--EDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTL------DHPDAVKLFTR 117 + DN LRRG P H ++G + + + + ++ ++ A K+ Sbjct: 116 LPCMDNDDLRRGKPTNHKVFGEAIAVLAGDALLNEAMKILVDYSLEEGKSALKATKIIAD 175 Query: 118 QLLE--LHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKE---- 171 + GQ +DI D + +E M L+KTG L ++ + ++ E Sbjct: 176 AAGSDGMIGGQIVDIINEDKE-EISLKELDYMHLKKTGELIKASIMSGAVLAEASEGDIK 234 Query: 172 DLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQ 231 L+ LGL FQI+DD ++ K+ +D K ++ TI + + Sbjct: 235 KLEGFGYKLGLAFQIKDDILDVVGNAKDLGKNVHKDQESNKNNYITIFGLEECKK----- 289 Query: 232 NILRQRTENIDIKKYCVHYLEDVGS 256 + ++I + C+ L + Sbjct: 290 -------KCVNITEECIEILSSIKG 307 >5E8H-A nrPDB Length = 330 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 63/272 (23%), Positives = 111/272 (40%), Gaps = 20/272 (7%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDI--EDN 69 + E +Y L GK+VR L A + E EM+H +SL+ DD+ DN Sbjct: 55 VQEAVRYSLLAGGKRVRPLLCIAVCELVGGDEATAMSAACAVEMIHTSSLIHDDLPCMDN 114 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAV-KLFTRQLLELHQ---- 124 + LRRG P H +YG + + + + L E + + + R ++EL + Sbjct: 115 ADLRRGKPTNHKVYGEDMAVLAGDALLALAFEHMTVVSSGLVAPERMIRAVVELARAIGT 174 Query: 125 -----GQGLDIYWRD-NYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKED----LK 174 GQ +D+ N E + + L KT L A L + E+ L+ Sbjct: 175 TGLVAGQMIDLASERLNPDKVGLEHLEFIHLHKTAALLEAAAVLGVIMGGGTEEEIEKLR 234 Query: 175 PLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPE-STQVQNI 233 +GL FQ+ DD ++ K+ +D+ GK ++P + + E + +++ Sbjct: 235 KYARCIGLLFQVVDDILDVTKSTEELGKTAGKDVMAGKLTYPRLIGLERSKEVAEKLRRE 294 Query: 234 LRQRTENIDIKKYCVHYLEDVGSFEYTRNTLK 265 ++ D K L + S+ R+ L+ Sbjct: 295 AEEQLLGFDPSK--AAPLVALASYIACRHNLE 324 >3ZCD-A nrPDB Length = 296 Score = 210 bits (536), Expect = 4e-55, Method: Composition-based stats. Identities = 60/275 (21%), Positives = 104/275 (37%), Gaps = 22/275 (8%) Query: 5 QETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLI- 63 +E +QR L E +Y + GK+VR L+ A L + E++H SL+ Sbjct: 26 REELQR-LYEAMRYSVMNGGKRVRPLLAYAACEALGGAPQRADAAACAVELIHAYSLVHD 84 Query: 64 -DDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTL-----DHPDAVKLFTR 117 D+ LRRG P H + + I +A+ + L E + +H +++ TR Sbjct: 85 DLPAMDDDDLRRGQPTTHRAFDEATAILAADGLQALAFEVLADTRRNPQEHAVCLEMLTR 144 Query: 118 QL-----LELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKE- 171 + GQ +D+ + + M KTG L +V L L S E Sbjct: 145 LARAAGSAGMVGGQAIDLGSVG--VALDQAALEVMHRHKTGALIEASVRLGALASGRAEP 202 Query: 172 ----DLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPES 227 L+ +GL FQ++DD ++ S + K+ +D K ++P + + + Sbjct: 203 ASLAALERYAEAIGLAFQVQDDILDVESDTATLGKTQGKDQAHNKPTYPALLGLEAAKGY 262 Query: 228 TQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRN 262 L +D L + + R Sbjct: 263 ALELRDL--ALAALDGFPPSADPLRQLARYIVERR 295 >5XN5-A nrPDB Length = 305 Score = 210 bits (534), Expect = 7e-55, Method: Composition-based stats. Identities = 55/265 (20%), Positives = 96/265 (36%), Gaps = 23/265 (8%) Query: 6 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLI-- 63 + L E +Y L GK+VR L A + E EM+H SL+ Sbjct: 27 DEPPAALHEAMRYALLAGGKRVRPALCLAACAVVGGREAWAMPAAAAVEMVHTMSLVHDD 86 Query: 64 DDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDH-----------PDAV 112 D+ LRRG P H +YG P + + + + L + D V Sbjct: 87 LPCMDDDDLRRGKPTCHVVYGEPIAVLTGDALLSLSFHHMARFDSYPPDIDADKHPARVV 146 Query: 113 KLFTRQLL-----ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFS 167 + L GQ +D+ + E + + L KT L +V + + Sbjct: 147 RAIGELARCIGSEGLVAGQVVDLEMTGSTETVPLERLEYIHLHKTAALLEASVVIGAILG 206 Query: 168 DYK----EDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWS 223 E L+ ++GL FQ+ DD ++ K+ +DL K ++P + + Sbjct: 207 GGSDEQIESLRMYARSIGLLFQVVDDILDVTKSSEELGKTAGKDLASDKTTYPKLLGLEK 266 Query: 224 RPE-STQVQNILRQRTENIDIKKYC 247 E + ++ + R++ D + Sbjct: 267 SREFAEKLLSDAREQLSGFDQETAA 291 >4GP1-A nrPDB Length = 358 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 67/305 (21%), Positives = 106/305 (34%), Gaps = 22/305 (7%) Query: 13 LEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKL 72 E Y ++ GK++R L+ A + + E++HN SL+ DDI D + Sbjct: 34 REAVLYQVKTGGKRLRPLLTLAAAEAVSGQWRPALPAAAIVELIHNYSLIYDDIIDRGDV 93 Query: 73 RRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDA-VKLFTRQLLELHQGQGLDIY 131 RRG P +G + I + E VL P K + + +G+ LDI Sbjct: 94 RRGLPTVRKAFGDNAAILVGIWYREAIEEAVLDTPKPTLFAKEVAEVIKAIDEGERLDIL 153 Query: 132 WR-----------DNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFS----DYKEDLKPL 176 + + T ++Y MV KTG L A L E Sbjct: 154 FEAAGRSDPYFVQARWREVTLDDYIKMVSLKTGALIAAAAKWGVLSVSDDRGLAEAAWNF 213 Query: 177 LNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSR---PESTQVQNI 233 G+ FQI DD +++ K +D+ E K + S E ++ I Sbjct: 214 GMAAGVAFQIIDDVLDIYGDPKKFGKEIGKDIKEHKRGNAVVAVALSHLGEGERRRLLEI 273 Query: 234 LRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSK 293 L + + V L+ VG+ E +A + + N L L L Sbjct: 274 LAREVVEEADVREAVALLDSVGAREEALRLAARYREEAERHLAKIPNNGTLKEL---LDF 330 Query: 294 MFKEE 298 + E Sbjct: 331 IVARE 335 >3LSN-A nrPDB Length = 304 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 58/270 (21%), Positives = 99/270 (36%), Gaps = 23/270 (8%) Query: 11 ILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLI--DDIED 68 L E +Y + GK+VR L+ A L ++ E++H SL+ D Sbjct: 31 RLYEAMRYSVMNGGKRVRPLLAYAACEALGGKPEQANGAACAVELIHAYSLVHDDLPAMD 90 Query: 69 NSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDA--------VKLFTRQLL 120 + LRRG P H + I + + + L +L DA V + Sbjct: 91 DDDLRRGQPTTHKAFDEACAILAGDGLQSLAFSALLDPALSDASAEIRLRMVTTLAQAAG 150 Query: 121 --ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKE-----DL 173 + GQ +D+ EY M KTG L +V L L S E L Sbjct: 151 PAGMVGGQAIDLGSVGLKLDQQALEY--MHRHKTGALIEASVILGALASGRAEKGELKAL 208 Query: 174 KPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPE-STQVQN 232 + +GL FQ++DD ++ S + K D+ K ++P + + + E + ++++ Sbjct: 209 QTYAQAIGLAFQVQDDILDVESDTATLGKRQGADIARDKPTYPALLGLAAAKEYALELRD 268 Query: 233 ILRQRTENIDIKKYCVHYLEDVGSFEYTRN 262 D L ++ + R Sbjct: 269 QALHALRPFD---AAAEPLRELARYIVERR 295 >3NF2-A nrPDB Length = 352 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 63/272 (23%), Positives = 99/272 (36%), Gaps = 16/272 (5%) Query: 23 PGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSI 82 GK VR L+ + E++HN SLL DD+ D + RR + Sbjct: 53 GGKAVRPALAVLSAEVTGAAPEVGVPGAVAVELVHNFSLLHDDLMDGDEQRRHRDTVWKV 112 Query: 83 YGIPSVINSANYVYFLGLEKVLTL---DHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCP 139 +G I + ++ L E +L L + A + T+ L GQ DI + + Sbjct: 113 HGPAQAILVGDALFALANEVLLELGTVEAGRATRRLTKASRSLIDGQAQDISYE-HRDRV 171 Query: 140 TEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKED----LKPLLNTLGLFFQIRDDYANLHS 195 + EE M KTG L A + + E L+ LGL FQ DD + Sbjct: 172 SVEECLEMEGNKTGALLACASSIGAVLGGADERTADTLEKYGYHLGLAFQAVDDLLGIWG 231 Query: 196 KEYSENKSFCEDLTEGKFSFPTI-HAIWSRPESTQVQNILRQRTENIDIKKYC------- 247 + K DL + K S P + S ++ IL + D + Sbjct: 232 DPDATGKQTWSDLRQRKKSLPVVAALAAGGAASERLGEILTADAKASDFANFSEEEFAAR 291 Query: 248 VHYLEDVGSFEYTRNTLKELEAKAYKQIDARG 279 +E+ G E+T + + A + +DA Sbjct: 292 AALIEEAGGREWTADEARRQHTIAIEALDAVD 323 >3TS7-A nrPDB Length = 324 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 55/281 (19%), Positives = 102/281 (36%), Gaps = 21/281 (7%) Query: 4 TQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLI 63 + + L + +Y + GK++R L+ A + V D L E +H SL+ Sbjct: 30 AADRMPERLHQAMRYSVLGGGKRMRPLLTYATGQTIGVAADLLDGPACAVEFIHVYSLIH 89 Query: 64 --DDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDA--------VK 113 D+ LRRG P H Y + I + + + L + ++ Sbjct: 90 DDLPAMDDDDLRRGKPTCHKAYDEATAILAGDGLQALAFHVLAQDPSIAVPAENRIAMIE 149 Query: 114 LFTRQLL--ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLF----- 166 + + GQ +D+ E M ++KTG L +V L L Sbjct: 150 TLAKASGPAGMVGGQAIDLASVGKKLDLPGLE--NMHIRKTGALIRASVRLACLARPGLP 207 Query: 167 SDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPE 226 ++ + L +GL FQI+DD + S + K+ +D K ++P + + E Sbjct: 208 AEQFDRLDHYAKCIGLAFQIQDDILDEESDTQTLGKTRGKDRDHNKPNYPALLGLSGAKE 267 Query: 227 STQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKEL 267 + + E++ L ++ F R + + L Sbjct: 268 KAEEMH--EAALESLAGFGPEADLLRELARFIIQRQSAENL 306 >4LLS-A nrPDB Length = 311 Score = 200 bits (510), Expect = 4e-52, Method: Composition-based stats. Identities = 53/262 (20%), Positives = 97/262 (37%), Gaps = 15/262 (5%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDI--EDN 69 ++E + GK++R L + + E LH SL+ DD+ DN Sbjct: 51 IVEAMAH-ATSGGKRLRGFLVLETARLHDIAAGEAIWSATAIEALHAYSLVHDDLPCMDN 109 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQ----- 124 +RRG P H + + + + + + L E V + ++ L L + Sbjct: 110 DDMRRGQPTVHKKWDDATAVLAGDALQTLAFELVTHPGASASAEVRADLALSLARASGAQ 169 Query: 125 ----GQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYK-EDLKPLLNT 179 GQ LDI + +E + KTG L G + + LK Sbjct: 170 GMVLGQALDIAAETARAPLSLDEITRLQQGKTGALIGWSAQAGARLAQADTAALKRYAQA 229 Query: 180 LGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTE 239 LGL FQI DD ++ K+ +D + GK +F ++ + + + +++ + + Sbjct: 230 LGLAFQIADDILDVTGDSAQVGKAVGKDASAGKATFVSLLGLDAAR--ARAMSLIDEACD 287 Query: 240 NIDIKKYCVHYLEDVGSFEYTR 261 ++ L + F R Sbjct: 288 SLATYGAKADTLRETARFVVRR 309 >3M9U-A nrPDB Length = 309 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 55/237 (23%), Positives = 90/237 (37%), Gaps = 17/237 (7%) Query: 6 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVP--EDKLQIIIEVTEMLHNASLLI 63 ++ L Y + GK++R L+ A L V ++ + E+LH SL+ Sbjct: 30 DSQDAQLAAAMTYSVLAGGKRLRPLLTVATMQSLGVTFVPERHWRPVMALELLHTYSLIH 89 Query: 64 DDI--EDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL- 120 DD+ DN LRRG P H +G + + + L + + D P ++ Q L Sbjct: 90 DDLPAMDNDALRRGEPTNHVKFGAGMATLAGDGLLTLAFQWLTATDLPATMQAALVQALA 149 Query: 121 ------ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLK 174 + GQ DI ++ +KTG L AV + E Sbjct: 150 TAAGPSGMVAGQAKDIQSEHVNLPLSQLRVL--HKEKTGALLHYAVQAGLILGQAPEAQW 207 Query: 175 P----LLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPES 227 P + GL FQI DD ++ S K+ +D E K ++P + ++ Sbjct: 208 PAYLQFADAFGLAFQIYDDILDVVSSPAEMGKATQKDADEAKNTYPGKLGLIGANQA 264 >1RTR-A nrPDB Length = 301 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 56/265 (21%), Positives = 96/265 (36%), Gaps = 16/265 (6%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDI--EDN 69 L E Y L GK++R L L + EM+H SL+ DD+ DN Sbjct: 30 LEESMLYSLNAGGKRIRPVLLLLTLDSLNTEYELGMKSAIALEMIHTYSLIHDDLPAMDN 89 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDH------PDAVKLFTRQLLE-- 121 RRG H +YG + I + + + E + + D ++ + Sbjct: 90 DDYRRGKLTNHKVYGEWTAILAGDALLTKAFELISSDDRLTDEVKIKVLQRLSIASGHVG 149 Query: 122 LHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDY----KEDLKPLL 177 + GQ LD+ E + + KTG L AV ++ KE L+ Sbjct: 150 MVGGQMLDMQSEGQPIDL--ETLEMIHKTKTGALLTFAVMSAADIANVDDTTKEHLESYS 207 Query: 178 NTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQR 237 LG+ FQI+DD + + E K DL K ++ ++ + Sbjct: 208 YHLGMMFQIKDDLLDCYGDEAKLGKKVGSDLENNKSTYVSLLGKDGAEDKLTYHRDAAVD 267 Query: 238 TENIDIKKYCVHYLEDVGSFEYTRN 262 +++ +L ++ Y+R+ Sbjct: 268 ELTQIDEQFNTKHLLEIVDLFYSRD 292 >2Q58-A nrPDB Length = 368 Score = 194 bits (494), Expect = 3e-50, Method: Composition-based stats. Identities = 67/296 (22%), Positives = 121/296 (40%), Gaps = 27/296 (9%) Query: 24 GKQVR----TKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVA 79 GK +R +S + + + D + ++ V E + L+ DDI D+ K RRG P Sbjct: 71 GKHIRGKILVLISSLSSAYSNIKRDSIYLLGWVVEAIQALILIADDIMDSGKFRRGAPCW 130 Query: 80 HSIYGIPSVINSANYVYFLGLEKVLTLDH-------PDAVKLFTRQLLELHQGQGLDIYW 132 + ++G + IN ++ L L + L K++ + GQ LD+ + Sbjct: 131 YIVHGQSNAINDIFFLKMLSLSLIFELSSVFGNDIVMKIQKIYNESIFFTVLGQHLDLSY 190 Query: 133 RD-NYTCPTEEEYKAMVLQKTGGL-------FGLAVGLMQLFSDYKEDLKPLLNTLGLFF 184 D + E Y +MV KT FGL + +Q+ S ++ +L LG F+ Sbjct: 191 FDLSKADKISERYFSMVEMKTSRYTFYMPVFFGLTLSEIQVSSAQLNLIEAILYKLGEFY 250 Query: 185 QIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIK 244 Q+ +D ++ N S +D+ K ++P + E +++ I +N + Sbjct: 251 QVHNDVSDY-----LFNDSNADDICRFKLTWPLQKSFEIADEEMKLK-ISENYGKNSSLV 304 Query: 245 KYCVHYLE-DVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEEN 299 K C + L+ + EY RN L K K I + L+ +S++ Sbjct: 305 KDCYNLLKINEHYLEYQRNALD-YLIKLVKDITDDSLQKVFIHLIHQISELITNSR 359 >3M0G-A nrPDB Length = 297 Score = 194 bits (492), Expect = 5e-50, Method: Composition-based stats. Identities = 53/262 (20%), Positives = 89/262 (33%), Gaps = 14/262 (5%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDI--EDN 69 L + Y Q GK++R L+ + + E LH SL+ DD+ DN Sbjct: 30 LRDAMAYAAQ-GGKRLRAFLAIESAAIHGISMAQAMPAALAVEALHAYSLVHDDMPCMDN 88 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLT--------LDHPDAVKLFTRQLLE 121 LRRG P H + + + + + + L E A Sbjct: 89 DDLRRGLPTVHKKWDDATAVLAGDALQTLAFELCTDPVLGSAENRVALVAALAQASGAEG 148 Query: 122 LHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKE-DLKPLLNTL 180 + GQ LDI T +E + KTG L A + + L L Sbjct: 149 MVYGQALDIAAETAAVPLTLDEIIRLQAGKTGALISFAAQAGAILAGADRGPLTAYATAL 208 Query: 181 GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN 240 GL FQI DD ++ E + K +D K +F ++ + ++ +++ + Sbjct: 209 GLAFQIADDILDVEGNEEAAGKRLGKDAEAHKATFVSLLGLAGAK--SRAADLVAEAEAA 266 Query: 241 IDIKKYCVHYLEDVGSFEYTRN 262 + L + R+ Sbjct: 267 LAPYGEAASTLRACARYVIERD 288 >3LOM-A nrPDB Length = 313 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 62/242 (25%), Positives = 96/242 (39%), Gaps = 20/242 (8%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDI--EDN 69 + Y L GK++R L + V + L II E+ H SL+ DD+ DN Sbjct: 38 IRSALHYALFSGGKRIRPILVYLAGDLIDVDQGVLDIIAAALELTHCYSLIHDDLPAMDN 97 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLE-------- 121 LRRG P H + + I + + L +E +L P + + Sbjct: 98 DDLRRGKPSCHKAFDEATAILVGDGMQALAIEVLLMRLSPLLPAAQVVAITQVLVNASGI 157 Query: 122 --LHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDY------KEDL 173 + GQ LD+ + TEE+ + + L KTG L LA M L + + K L Sbjct: 158 SGMVSGQSLDL-SELAKSSVTEEQLREIHLLKTGKLI-LACFEMVLAAQHEVSEQIKSAL 215 Query: 174 KPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNI 233 + +GL FQ++DDY +L++ K D K +F T+ E V Sbjct: 216 RTYGKHIGLVFQMQDDYLDLYAPTQILGKGRSSDQANQKTTFATLFNKQQLEEEIAVHYQ 275 Query: 234 LR 235 + Sbjct: 276 IA 277 >3AQ0-A nrPDB Length = 348 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 62/293 (21%), Positives = 110/293 (37%), Gaps = 27/293 (9%) Query: 12 LLEPYKYLLQLP--GKQVRT--KLSQAFNHWLKVPEDKL---------------QIIIEV 52 L +Y + GKQ R+ L A ++VPE + + I E+ Sbjct: 36 LASAAEYFFKRGVQGKQFRSTILLLMATALDVRVPEALIGESTDIVTSELRVRQRGIAEI 95 Query: 53 TEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAV 112 TEM+H ASLL DD+ D++ RRG + + G + + +++ + L + + V Sbjct: 96 TEMIHVASLLHDDVLDDADTRRGVGSLNVVMGNKMSVLAGDFLLSRACGALAALKNTEVV 155 Query: 113 KLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKED 172 L + L G+ ++I + + Y KT L + + + + + Sbjct: 156 ALLATAVEHLVTGETMEITS-STAARYSMDYYMQKTYYKTASLISNSCKAVAVLTGQTAE 214 Query: 173 LK----PLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPEST 228 + LGL FQ+ DD + S K D+ G + P + A+ P+ Sbjct: 215 VAVLAFEYGRNLGLAFQLIDDILDFTGTSASLGKGSLSDIRHGVITAPILFAMEEFPQLR 274 Query: 229 QVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGN 281 +V + + N+DI + YL + R E A I + Sbjct: 275 EVVDQVAADPRNVDI---ALEYLGKSKGIQRARELAMEHANLAAAAIGSLPET 324 >1WL1-A nrPDB Length = 299 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 77/274 (28%), Positives = 130/274 (47%), Gaps = 19/274 (6%) Query: 1 MEKTQETVQRILLE--PYKYLLQLP--GKQVRTKLSQAF--NHWLKVPEDKLQIIIEVTE 54 +EK +E +++IL + P + + LP GK +R +LS N +++ ED + + + Sbjct: 13 LEKVKERIEQILSQFFPEQIMKDLPLYGKMLRVRLSILSFKNRGVEIGEDAISSLAALEL 72 Query: 55 MLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKL 114 + ASLL DD+ D ++ RRG + +YG + + + + V V + + + Sbjct: 73 VA-LASLLHDDVIDGARFRRGKETINFMYGDKAAVAAGDLVLVSAFHTVEEIGNNKLRRA 131 Query: 115 FTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLF-SDYKEDL 173 F + ++ + + ++ R Y T+EEY +V K+G LFGLA+ L L + EDL Sbjct: 132 FLNVIGKMSEAELIEQLSR--YKPITKEEYLRIVEGKSGALFGLALQLPALLEGELGEDL 189 Query: 174 KPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNI 233 L T+G +Q+ DD + E K DL G SFP + A+ PE+ Sbjct: 190 YNLGVTIGTIYQMFDDIMDFAGMEK-IGKDGFLDLKNGVASFPLVTAMEKFPEA------ 242 Query: 234 LRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKEL 267 RQ EN D + ++ + G + TLK L Sbjct: 243 -RQMFENRDWSG-LMSFMREKGILKECEETLKVL 274 >3TC1-A nrPDB Length = 315 Score = 184 bits (466), Expect = 5e-47, Method: Composition-based stats. Identities = 52/261 (19%), Positives = 107/261 (40%), Gaps = 5/261 (1%) Query: 18 YLLQLPGKQVRTKLSQAF--NHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRG 75 + P K +R+KL A + DK + + EM+ ASLL DD+ D + +RR Sbjct: 29 FSKIGPSKMLRSKLMLALLNEKTDAILLDKALNLCTIVEMIQTASLLHDDVIDKATMRRK 88 Query: 76 FPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDN 135 P ++++G + + + Y ++ + + + +L L +G+ D++ + Sbjct: 89 LPSINALFGNFNAVMLGDVFYSKAFFELSKMGE-LIAQALSNAVLRLSRGEIEDVFVGEC 147 Query: 136 YTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKP-LLNTLGLFFQIRDDYANLH 194 + +++Y ++ KT ++ M + + + G+ FQI DD ++ Sbjct: 148 FNSD-KQKYWRILEDKTAHFIEASLKSMAILLNKDAKIYADFGLNFGMAFQIIDDLLDIT 206 Query: 195 SKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDV 254 + K D EGK + P + + Q I + ++ +I ++ + Sbjct: 207 QDAKTLGKPNFSDFKEGKTTLPYLLLYEKLNQHDQGLLISYFKQDSHEIIEWTKEKFKQY 266 Query: 255 GSFEYTRNTLKELEAKAYKQI 275 G E T T + KA + I Sbjct: 267 GIIEETLKTAQVYSKKALEAI 287 >3P8L-A nrPDB Length = 302 Score = 183 bits (464), Expect = 8e-47, Method: Composition-based stats. Identities = 58/238 (24%), Positives = 93/238 (39%), Gaps = 16/238 (6%) Query: 4 TQETVQRILLEPYKYLLQLPGKQVRTKLSQAF-NHWLKVPEDKLQIIIEVTEMLHNASLL 62 + T L E Y + GK++R L + K E + + EM+H SL+ Sbjct: 30 AEYTENERLKEAMLYSIHAGGKRLRPLLVLTTVAAFQKEMETQDYQVAASLEMIHTYSLI 89 Query: 63 IDDIEDNSK--LRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL 120 DD+ LRRG P H ++G + I + + + + + + K+ Q L Sbjct: 90 HDDLPAMDDDDLRRGKPTNHKVFGEATAILAGDGLLTGAFQLLSLSQLGLSEKVLLMQQL 149 Query: 121 -------ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKED- 172 + GQ DI T EE A+ +KTG L A+ + ++ E+ Sbjct: 150 AKAAGNQGMVSGQMGDI--EGEKVSLTLEELAAVHEKKTGALIEFALIAGGVLANQTEEV 207 Query: 173 ---LKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPES 227 L + GL FQIRDD + S E K D K ++P + I ++ Sbjct: 208 IGLLTQFAHHYGLAFQIRDDLLDATSTEADLGKKVGRDEALNKSTYPALLGIAGAKDA 265 >4LFG-A nrPDB Length = 290 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 54/265 (20%), Positives = 100/265 (37%), Gaps = 22/265 (8%) Query: 8 VQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVP-EDKLQIIIEVTEMLHNASLLIDDI 66 + L E Y + GK++R L L++P + EM+H SL+ DD+ Sbjct: 22 ISEKLNEAVLYSINAGGKRIRPILFLEVIEALQIPLTESHFKAAAALEMIHTGSLIHDDL 81 Query: 67 --EDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHP-----DAVKLFTRQL 119 DN RRG H + + I + + ++ + D P D V+ + Sbjct: 82 PAMDNDDYRRGQLTNHKKFDEATAILAGDSLFLDAFGMLAETDFPTDVTVDLVRSLSSAS 141 Query: 120 L--ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKP-- 175 + GQ LD+ + + + KTG L + E+L Sbjct: 142 GTFGMVGGQMLDMAAEGKK--LNLKNLQLIHRHKTGQLLAYPFWAAARVAQLDENLLATF 199 Query: 176 --LLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSR-----PEST 228 + +GL FQ+RDD ++ + K+ +D+ K ++P + + Sbjct: 200 LEIGMIIGLAFQVRDDILDITANFEEIGKTPKKDVMAEKMTYPHLLGLNESYQILDESLD 259 Query: 229 QVQNILRQRTENIDIK-KYCVHYLE 252 Q + ILR+ ++ I + + +E Sbjct: 260 QAEAILRKLSDEIAFAPQKILSLIE 284 >3NPK-A nrPDB Length = 291 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 56/254 (22%), Positives = 95/254 (37%), Gaps = 19/254 (7%) Query: 6 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPE-DKLQIIIEVTEMLHNASLLID 64 E+ E +L+ GK R +L + K ++ + E +H SL+ D Sbjct: 21 ESFHPFFNEALALMLKAGGKHFRAQLLLSVVQSNKPELLNQALDVALALEFIHTYSLIHD 80 Query: 65 DI--EDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKL-------F 115 D+ DN+ RRG P H Y + I + + + D +K+ F Sbjct: 81 DLPAMDNADFRRGIPTLHKSYDETTAILVGDALNTEAFLVLSHAHLKDEIKIKLIKTLAF 140 Query: 116 TRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLM----QLFSDYKE 171 L + GQ +D ++ D E E+ KT L A+ + +L ++ Sbjct: 141 NAGLNGMVIGQAIDCFFEDKRLSLNELEFL--HTHKTARLIAAALKMGCEICELNNEESN 198 Query: 172 DLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSR-PESTQV 230 + L LGL FQI DD ++ + + K D+ K SF + + + Sbjct: 199 QIYKLGLKLGLIFQINDDIIDVTTSQEQSGKPTNNDI--HKNSFVNLLGLEQAIKTKENL 256 Query: 231 QNILRQRTENIDIK 244 N Q E ++ K Sbjct: 257 LNECEQDLEKLNEK 270 >2J1O-A nrPDB Length = 268 Score = 178 bits (451), Expect = 3e-45, Method: Composition-based stats. Identities = 46/240 (19%), Positives = 76/240 (31%), Gaps = 50/240 (20%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSK 71 + E +Y L GK+VR L A + E EM+H SL+ DD+ Sbjct: 40 IHEAMRYSLLAGGKRVRPVLCIAACELVGGEESLAMPAACAVEMIHTMSLIHDDV----- 94 Query: 72 LRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHP--------DAVKLFTRQLL--E 121 YG + + + + E + + AV + + Sbjct: 95 -----------YGEDVAVLAGDALLSFAFEHLASATSSEVSPARVVRAVGELAKAIGTEG 143 Query: 122 LHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYK----EDLKPLL 177 L GQ +DI E K + L KT L + L + E L+ Sbjct: 144 LVAGQVVDIS------NVGLEHLKFIHLHKTAALLEASAVLGGIIGGGSDEEIERLRKFA 197 Query: 178 NTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQR 237 +GL FQ+ DD ++ K ++P + + E + N + Sbjct: 198 RCIGLLFQVVDDILDVT--------------IADKLTYPKLMGLEKSREFAEKLNTEARD 243 >3IPI-A nrPDB Length = 295 Score = 174 bits (441), Expect = 4e-44, Method: Composition-based stats. Identities = 51/273 (18%), Positives = 107/273 (39%), Gaps = 22/273 (8%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSK 71 L + +++ GK++R + + + EM+H+ASL+ DD+ D Sbjct: 30 LKKMVEHVCHSGGKRIRPIILLLVSEICSGSYSRSLNAALAVEMMHSASLIHDDLLDQGL 89 Query: 72 LRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIY 131 +RR P A +G + +Y+ + + ++ F + +++ +G+ LD+ Sbjct: 90 VRRNLPSAPEKFGPSGALLCGDYLIAKSIAFISPYGE-KVIQDFGKAGMDMAEGEVLDLK 148 Query: 132 WRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKP----LLNTLGLFFQIR 187 D E +Y + +KT LF ++ + +E+L N LG +QI Sbjct: 149 LEDE--SFGENDYFKCIYKKTASLFAISASIGAYTGGAEEELAERFSHFGNALGTAYQIV 206 Query: 188 DDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDI---- 243 DD E E K E KF+ T+ I+ + ST + L++ + + + Sbjct: 207 DDILEF--LEVVEGK-------ESKFTSETLPHIYMK--STSKEEALKKSIDCVKLHVAA 255 Query: 244 KKYCVHYLEDVGSFEYTRNTLKELEAKAYKQID 276 K + + + + + + ++ Sbjct: 256 AKETLETFRECPARDKLFQITDYITVDMLENLE 288 >3Q1O-A nrPDB Length = 310 Score = 173 bits (439), Expect = 7e-44, Method: Composition-based stats. Identities = 57/269 (21%), Positives = 102/269 (37%), Gaps = 26/269 (9%) Query: 6 ETVQRILLEPYKYLLQLPGKQVRTKLSQA-FNHWLKVPE-----DKLQIIIEVTEMLHNA 59 E+ L + + ++ GK+ R KL A + + + I E LH Sbjct: 37 ESFHPYLEKAFFEMVLNGGKRFRPKLFLAVLCALVGQKDYSNQQTEYFKIALSIECLHTY 96 Query: 60 SLLIDDI--EDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLT--LDHPDAVKLF 115 SL+ DD+ DN+ LRR P H+ Y + + + + E + L+ V+L Sbjct: 97 SLIHDDLPCMDNAALRRNHPTLHAKYDETTAVLIGDALNTYSFELLSNALLESHIIVELI 156 Query: 116 -----TRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYK 170 + + GQ LD Y+ + T E+ + KT L ++ + + S K Sbjct: 157 KILSANGGIKGMILGQALDCYFEN--TPLNLEQLTFLHEHKTAKLISASLIMGLVASGIK 214 Query: 171 ED-----LKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRP 225 ++ L+ +GL FQ+ DD ++ E K+ D K SF + + Sbjct: 215 DEELFKWLQAFGLKMGLCFQVLDDIIDVTQDEEESGKTTHLD--SAKNSFVNLLGLERAN 272 Query: 226 ESTQVQNILRQRTENIDIKKYCVHYLEDV 254 Q + ++D K L++ Sbjct: 273 NYAQTLK--TEVLNDLDALKPAYPLLQEN 299 >1UBV-A nrPDB Length = 367 Score = 170 bits (431), Expect = 6e-43, Method: Composition-based stats. Identities = 70/294 (23%), Positives = 109/294 (37%), Gaps = 35/294 (11%) Query: 11 ILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDK-------LQIIIEVTEMLHNASLLI 63 L E +Y GK R A L P K + E+ ASL+ Sbjct: 58 RLKEVLQYNA-PGGKCNRGLTVVAAYRELSGPGQKDAESLRCALAVGWCIELFQAASLVA 116 Query: 64 DDIEDNSKLRRGFPVAHSIYGIP-SVINSANYVYFLGLEKV--LTLDHPDAV---KLFTR 117 DDI D S RRG + G+ IN + + + P V +LF + Sbjct: 117 DDIMDQSLTRRGQLCWYKKEGVGLDAINDSFLLESSVYRVLKKYCRQRPYYVHLLELFLQ 176 Query: 118 QLLELHQGQGLDIY----WRDNYTCPTEEEYKAMVLQKTGGL-FGLAVGLMQLFSDYK-- 170 + GQ LD+ + + + +EE YKA+V KT F L V Sbjct: 177 TAYQTELGQMLDLITAPVSKVDLSHFSEERYKAIVKYKTAFYSFYLPVAAAMYMVGIDSK 236 Query: 171 ---EDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWS-RPE 226 E+ K +L +G +FQI+DDY + + D+ + K S+ + + PE Sbjct: 237 EEHENAKAILLEMGEYFQIQDDYLDCFGDPA-LTGAVGTDIQDNKCSWLVVQCLQRVTPE 295 Query: 227 STQV--QNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDAR 278 Q+ N R+ E + K E VG R ++ E +Y+++ Sbjct: 296 QRQLLEDNYGRKEPEKVAKVK---ELYEAVG----MRAAFQQYEESSYRRLQEL 342 >2H8O-A nrPDB Length = 335 Score = 167 bits (423), Expect = 5e-42, Method: Composition-based stats. Identities = 55/265 (20%), Positives = 99/265 (37%), Gaps = 19/265 (7%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLI--DDIEDN 69 LLE ++ + GK++R L L + + E LH SL+ D+ Sbjct: 73 LLEAMRHGVLNGGKRLRPFLVIESVALLGGDAEAGLHVGAALECLHCYSLVHDDLPAMDD 132 Query: 70 SKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLEL------- 122 LRRG P H + + I + + + L + + + D+P A + ++ L Sbjct: 133 DDLRRGQPTVHRKFDEATAILAGDSLLTLAFDIIASDDNPLAAERKAALVISLARAAGIG 192 Query: 123 --HQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSD----YKEDLKPL 176 GQ LD+ P E+ + KTG L A + + ++ L+ Sbjct: 193 GMAGGQALDLAAEKK--APDEDGIITLQAMKTGALLRFACEAGAIIAGSNQAERQRLRLF 250 Query: 177 LNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQ 236 +GL FQ+ DD +L + + K+ +D GK + + E ++Q + + Sbjct: 251 GEKIGLSFQLADDLLDLTADAATMGKATGKDAARGKGTLVALRGEAWARE--KLQEQVAE 308 Query: 237 RTENIDIKKYCVHYLEDVGSFEYTR 261 +E + L F R Sbjct: 309 ASELLAPYGEKAAILIAAARFIAER 333 >6B02-A nrPDB Length = 341 Score = 163 bits (414), Expect = 6e-41, Method: Composition-based stats. Identities = 68/308 (22%), Positives = 121/308 (39%), Gaps = 28/308 (9%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPED-------KLQIIIEVTEMLHNASLLID 64 L + +Y L GK+ R + L+ PE+ + + E+L +++D Sbjct: 33 LKKVLEYNL-AGGKKARGLTTLFAYEMLEKPENITEETIYLAKTLGWCVEILQGFLVMLD 91 Query: 65 DIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPD------AVKLFTRQ 118 DI D S RRG P + + + + + + F + VL D V+LF Sbjct: 92 DIMDGSTTRRGVPCWYQLPEVGLAAVNDSSLMFSSIFYVLHAHFADKKIYTNLVELFNES 151 Query: 119 LLELHQGQGLDIYWR----DNYTCPTEEEYKAMVLQKTGGL-FGLAVGLMQLFSDYKE-- 171 L+ GQ LD+ +Y+ T E Y A+V KT + L V L L ++ + Sbjct: 152 LMHTSIGQHLDVTMERRQKSDYSLFTIERYNAIVKYKTAYYTYQLPVCLGMLLANISDPV 211 Query: 172 ---DLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPEST 228 + + +G FFQI+DDY + + E K D+ E K S+ + A+ S Sbjct: 212 LHQKAEDMCLEIGKFFQIQDDYIDCYGDESLTGK-MGTDIQEAKCSWLAVMALQRCSASQ 270 Query: 229 QVQNILRQRTENIDIKKYCVHYLEDVGSFE-YTRNTLKELEAKAYKQIDARGG-NPEL-V 285 ++ ++ + + + E Y + + E+ + +P L V Sbjct: 271 KIVFTTCYGSKEPAHIERIKELYKQLQLPELYAQEETRMYESLIKQAHGLPSELSPALFV 330 Query: 286 ALVKHLSK 293 L+ + K Sbjct: 331 RLIHMIYK 338 >1WMW-A nrPDB Length = 330 Score = 162 bits (409), Expect = 2e-40, Method: Composition-based stats. Identities = 65/309 (21%), Positives = 111/309 (35%), Gaps = 18/309 (5%) Query: 6 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDD 65 + + + + + GK +R L+ P + E+ N L+ DD Sbjct: 21 DHPDPLYRDLLQDYPRRGGKMLRGLLTVYSALAHGAPLEAGLEAATALELFQNWVLVHDD 80 Query: 66 IEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLT-----LDHPDAVKLFTRQLL 120 IED S+ RRG P H ++ +P +N+ + ++ + L P+ + F + Sbjct: 81 IEDGSEERRGRPALHRLHPMPLALNAGDAMHAEMWGLLAEGLARGLFPPEVLLEFHEVVR 140 Query: 121 ELHQGQGLDIYWRDNYTCPTE-EEYKAMVLQKTGGLFGLA-VGLMQLFSDYKEDL--KPL 176 GQ LD+ W T E+Y MV K +A + L L + + Sbjct: 141 RTAYGQHLDLLWTLGGTFDLRPEDYFRMVAHKAAYYTAVAPLRLGALLAGKTPPAAYEEG 200 Query: 177 LNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRP----ESTQVQN 232 LG FQI DD NL E K DL EGK + + + P Sbjct: 201 GLRLGTAFQIVDDVLNLEGGEA-YGKERAGDLYEGKRTLILLRFLEEAPPEERARALALL 259 Query: 233 ILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDA----RGGNPELVALV 288 L + + + + L + + + K L+A+ ++A G L L Sbjct: 260 ALPREAKPEAEVGWLLERLLASRALAWAKAEAKRLQAEGLALLEAAFQDLPGKEALDHLR 319 Query: 289 KHLSKMFKE 297 L+ + + Sbjct: 320 GLLAALVER 328 >3PKO-A nrPDB Length = 334 Score = 161 bits (408), Expect = 3e-40, Method: Composition-based stats. Identities = 50/269 (18%), Positives = 106/269 (39%), Gaps = 12/269 (4%) Query: 19 LLQLPGKQVRTKLSQAFNHWLKVPED-KLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFP 77 LL+ GK +R F+ + +LQ E+LH +L+ DD+ D+S RRG Sbjct: 50 LLKSGGKLLRPGYFYLFSTFGNAATPAQLQAGAAAIEILHVGTLIHDDVIDDSPTRRGVR 109 Query: 78 VAHSIYGIPSVINSANYVYFLGLEKVLTLDHPD-AVKLFTRQLLELHQGQG--LDIYWRD 134 YG + I + ++++ + ++VL ++ + + QG+ +D+ +R+ Sbjct: 110 TIQMTYGQRNAIYAGDFMFTVYFDQVLKSTTDRSLIQNHIDAMHRILQGELHQMDLNYRE 169 Query: 135 NYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYK----EDLKPLLNTLGLFFQIRDDY 190 + T + Y + KT LF L+ + + + + +G +Q+ DD Sbjct: 170 D---ITLDAYLNEIAGKTAELFALSCYQGAQLAGAPQSVIDRTRDIGIAIGCAYQMLDDI 226 Query: 191 ANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHY 250 + K EDL G +S P + ++ P + +++ ++ K+ Sbjct: 227 LDYAGDPKRTQKPVLEDLRSGVYSLPLLLSLSHAPRDFHKL-LKKKQAMTLEDIKHVQAL 285 Query: 251 LEDVGSFEYTRNTLKELEAKAYKQIDARG 279 + + ++ +A I Sbjct: 286 VAQYDGVGAAKQLAQDYTDRALTLIQQLP 314 >5XN6-C nrPDB Length = 304 Score = 155 bits (392), Expect = 2e-38, Method: Composition-based stats. Identities = 47/208 (22%), Positives = 76/208 (36%), Gaps = 27/208 (12%) Query: 7 TVQRILLEPYKYLLQLPG------KQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS 60 + +Y + K+ L A L P + EMLH AS Sbjct: 26 RTPERIHSAMRYAVLPGAGNEGTAKRAPPVLCVAACELLGAPREAALPAAVALEMLHAAS 85 Query: 61 LLIDDIE--DNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEK-VLTLDHPDAV--KLF 115 L+ DD+ D + RRG P H+ YG + + + ++ L + PD V + Sbjct: 86 LVHDDLPCFDAAPTRRGRPSTHAAYGTDMAVLAGDALFPLAYTHVIAHTPSPDPVPHAVL 145 Query: 116 TRQLLELHQ---------GQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLF 166 R L EL + GQ LD+ T E E ++ +K G + + + Sbjct: 146 LRVLGELARAVGSTGMAAGQFLDLAG---ATALGEAEVMKVLTKKFGEMAECSAACGAML 202 Query: 167 SDYKED----LKPLLNTLGLFFQIRDDY 190 D L+ T+G+ +Q+ DD Sbjct: 203 GGAGPDEEAALRRYGRTIGVLYQLVDDI 230 >3LK5-A nrPDB Length = 380 Score = 148 bits (375), Expect = 2e-36, Method: Composition-based stats. Identities = 58/338 (17%), Positives = 109/338 (32%), Gaps = 40/338 (11%) Query: 2 EKTQETVQRILLEPYKYL---LQLPGKQVRTK------LSQAFNHWLKVPEDKLQIIIEV 52 E T + + + +L + GK++R L+ + + + Sbjct: 37 ELTIADIGAPVTDAVAHLRSFVLNGGKRIRPLYAWAGFLAAQGHKNSSEKLESVLDAAAS 96 Query: 53 TEMLHNASLLIDDIEDNSKLRRGFPVAHSI----------------YGIPSVINSANYVY 96 E + +L+ DDI D+S RRG P H +G+ I + + Sbjct: 97 LEFIQACALIHDDIIDSSDTRRGAPTVHRAVEADHRANNFEGDPEHFGVSVSILAGDMAL 156 Query: 97 FLGLEKVLTLDHPDAVKLFTRQL-----LELHQGQGLDIYWRDNYTCPTEEEYKAMVLQK 151 + + TR E+ GQ LDIY + E ++ K Sbjct: 157 VWAEDMLQDSGLSAEALARTRDAWRGMRTEVIGGQLLDIYLESHANESVELA-DSVNRFK 215 Query: 152 TGGL-FGLAVGLMQLFSDYK----EDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCE 206 T + L + + L + +G+ FQ+RDD + K + Sbjct: 216 TAAYTIARPLHLGASIAGGSPQLIDALLHYGHDIGIAFQLRDDLLGVFGDPAITGKPAGD 275 Query: 207 DLTEGKFSFPTIHAIWSR----PESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRN 262 D+ EGK + A+ PE+ + + + ++ G+ E Sbjct: 276 DIREGKRTVLLALALQRADKQSPEAATAIRAGVGKVTSPEDIAVITEHIRATGAEEEVEQ 335 Query: 263 TLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE 300 + +L +D E+ A ++ L+ E E Sbjct: 336 RISQLTESGLAHLDDVDIPDEVRAQLRALAIRSTERRE 373 >3CP6-A nrPDB Length = 376 Score = 148 bits (375), Expect = 2e-36, Method: Composition-based stats. Identities = 68/309 (22%), Positives = 115/309 (37%), Gaps = 28/309 (9%) Query: 11 ILLEPYKYLLQLPGKQVRTK-LSQAFNHWLK------VPEDKLQIIIEVTEMLHNASLLI 63 L E +Y GK R + AF ++ + + E+L L+ Sbjct: 67 RLKEVLEYNAI-GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVA 125 Query: 64 DDIEDNSKLRRGFPVAHSIYGIP-SVINSANYV--YFLGLEKVLTLDHP---DAVKLFTR 117 DDI D+S RRG + G+ IN AN + L K+ + P + ++LF + Sbjct: 126 DDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQ 185 Query: 118 QLLELHQGQGLDI----YWRDNYTCPTEEEYKAMVLQKTGGL-FGLAVGLMQLFSDYKED 172 + GQ LD+ + TE+ YK++V K F L + + + Sbjct: 186 SSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKAAFYSFYLPIAAAMYMAGIDGE 245 Query: 173 -----LKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIW-SRPE 226 K +L +G FFQI+DDY +L K D+ + K S+ + + + PE Sbjct: 246 KEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGK-IGTDIQDNKCSWLVVQCLQRATPE 304 Query: 227 STQV--QNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPEL 284 Q+ +N ++ E + K L+ F +Q A Sbjct: 305 QYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVF 364 Query: 285 VALVKHLSK 293 + L + + K Sbjct: 365 LGLARKIYK 373 >4KK2-A nrPDB Length = 366 Score = 143 bits (362), Expect = 7e-35, Method: Composition-based stats. Identities = 65/312 (20%), Positives = 106/312 (33%), Gaps = 30/312 (9%) Query: 13 LEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDK------LQIIIEVTEMLHNASLLIDDI 66 +E GK VR LK E + E L L++DDI Sbjct: 60 VERMIDYTVPGGKMVRGYSVVDSYQLLKGEELTDDEIFLSSALGWCIEWLQAYFLVLDDI 119 Query: 67 EDNSKLRRGFPVAHSIYGIPSVINSANYVYFLG----LEKVLTLDHP---DAVKLFTRQL 119 D S RRG P + + I + + + + K P D V LF Sbjct: 120 MDESHTRRGQPCWFRLPKVGM-IAANDGILLRNHVPRILKKHFRGKPYYVDLVDLFNEVE 178 Query: 120 LELHQGQGLDIY----WRDNYTCPTEEEYKAMVLQKTGGL-FGLAVGLMQLFSDYKED-- 172 + GQ +D+ + + + ++ +V KT F L V L D Sbjct: 179 FQTASGQMIDLITTLVGEKDLSKYSLSIHRRIVQYKTAYYSFYLPVACALLMFGEDLDKH 238 Query: 173 --LKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQV 230 +K +L +G +FQ++DDY + K D+ + K S+ + A+ E + Sbjct: 239 VEVKNVLVEMGTYFQVQDDYLDCFGAPEVIGK-IGTDIEDFKCSWLVVKALELANEEQKK 297 Query: 231 ---QNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVAL 287 +N ++ ++ K H L FE T K I+ L Sbjct: 298 TLHENYGKKDPASVAKVKEVYHTLNLQAVFEDYEATS---YKKLITSIENHPSKAVQAVL 354 Query: 288 VKHLSKMFKEEN 299 L K++K + Sbjct: 355 KSFLGKIYKRQK 366 >4FP4-A nrPDB Length = 285 Score = 141 bits (355), Expect = 4e-34, Method: Composition-based stats. Identities = 50/215 (23%), Positives = 91/215 (42%), Gaps = 19/215 (8%) Query: 1 MEKTQETVQRI-LLEPYKYLLQLPGKQVRTKLSQAFNHWL---KVPEDKLQIIIEVTEML 56 + K E ++ I L + ++ ++ PGK +R L F + + + + ++ + E+L Sbjct: 21 LNKVGEELEPISLRKAVRHYIETPGKLLRPLLLLTFTYSIDRRSIMDPRILEAAAIVELL 80 Query: 57 HNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFT 116 H SLL DD+ D RRG ++YG I +++++ ++ + L D V Sbjct: 81 HVVSLLQDDVMDQHDQRRGIKTPRAMYGDGRAIVASDWLIAESIKMAVNLG-ADVVTYLA 139 Query: 117 RQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYK---EDL 173 L GQ LD+ + KT L A+ + + + E Sbjct: 140 DVAQRLSVGQALDLEGERDKAA----------EFKTAPLIEAALVMPLVILGRRELIETA 189 Query: 174 KPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDL 208 K L LG+ +Q DDY++ + E E KS ++ Sbjct: 190 KKLGTKLGILYQYSDDYSD-ENVERPETKSIANEI 223 >3RBM-A nrPDB Length = 396 Score = 135 bits (340), Expect = 2e-32, Method: Composition-based stats. Identities = 62/337 (18%), Positives = 121/337 (35%), Gaps = 48/337 (14%) Query: 5 QETVQRILLEPYKYLLQ---LPGKQVRTKLSQAFNHWLK------VPEDKLQIIIEVTEM 55 +E ++ + + YK L L GK R L ++K +K + E+ Sbjct: 58 EEEIKEHISKYYKLLFDYNCLGGKNNRGILVILIYEYVKNRDINSSEWEKAACLAWCIEI 117 Query: 56 LHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFL-GLEKVLTLDH------ 108 L A L+ DDI D ++RR + + + + + + + K++ + Sbjct: 118 LQAAFLVADDIMDKGEMRRNKYCWYLLKDVETKNAVNDVLLLYNSIYKLIEIYLRNESCY 177 Query: 109 PDAVKLFTRQLLELHQGQGLDIY-WRDNYTCPTEE----------------------EYK 145 D + F L+ GQ LD + D Y+ E YK Sbjct: 178 VDVIATFRDATLKTIIGQHLDTNIFSDKYSDAHREIDVNNINVPEQPVIDINMINFGVYK 237 Query: 146 AMVLQKTGGL-FGLAVGLMQLFSDYK------EDLKPLLNTLGLFFQIRDDYANLHSKEY 198 +V+ KT F L + L + + ++ + +G +FQI DDY ++ Sbjct: 238 NIVIHKTAYYSFFLPIVCGMLLAGIAVDNLIYKKIEDISMLMGEYFQIHDDYLDIFGDST 297 Query: 199 SENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFE 258 K D+ K ++P I E +++ + N+ K E + Sbjct: 298 KTGK-VGSDIQNNKLTWPLIKTFELCSEPDKIKIVKNYGKNNLACVKVIDSLYEQYKIRK 356 Query: 259 YTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF 295 + + K +AK I+ + + ++K+L ++ Sbjct: 357 HYESYEKAQKAKILSAINEL-HHEGIEYVLKYLLEIL 392 >2AZK-A nrPDB Length = 289 Score = 130 bits (327), Expect = 6e-31, Method: Composition-based stats. Identities = 57/209 (27%), Positives = 87/209 (41%), Gaps = 16/209 (7%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSK 71 L++ Y+L+ GK+ R L+ F L E+LH+ASL +DDI D Sbjct: 38 LVDISSYILK-DGKRFRGTLNMFFTVALGGDIKDSYGGALAIEILHSASLALDDIVDLDA 96 Query: 72 LRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIY 131 RRG A +YG VI NY+ L + T DA+ + G D+Y Sbjct: 97 TRRGDKAAWVVYGNRKVIFITNYLIPTALRIIQTSYGDDALNTSIELEKDTSVGALRDMY 156 Query: 132 WRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLN---TLGLFFQIRD 188 + Y + KTG LF L+ L S + + +L+ LG+ +Q+ D Sbjct: 157 DNSD--------YIRTIELKTGSLFKLSTVLSAYASKHYNTKQQMLDVGKYLGIIYQVID 208 Query: 189 DYANLHSKEYSENKSFCEDL----TEGKF 213 D+ + +K+ E + L EGK Sbjct: 209 DFVDYKTKKVEEIDGSAKQLFKYYREGKL 237 >5AHU-B nrPDB Length = 294 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 47/282 (16%), Positives = 93/282 (32%), Gaps = 35/282 (12%) Query: 50 IEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDH- 108 + E L L+ DDI DNS RRG P + + + + ++ + Sbjct: 16 GWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFF 75 Query: 109 ------PDAVKLFTRQLLELHQGQGLDIYWR---------------DNYTCPTEEEYKAM 147 D + F R GQ D+ ++ T YK + Sbjct: 76 ADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRI 135 Query: 148 VLQKTGGLFG-LAVGLMQLFSDYKEDL-----KPLLNTLGLFFQIRDDYANLHSKEYSEN 201 V KT L + + + S+ + + L +G +FQ++DD + + Sbjct: 136 VKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLG 195 Query: 202 KSFCEDLTEGKFSFPTIHAIWSRPE---STQVQNILRQRTENIDIKKYCVHYLEDVGSFE 258 K D+ + K S+ + + + N +E + + + G + Sbjct: 196 K-VGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYV 254 Query: 259 YTRNTLKELEAKAYKQIDARGGNPELVALVKHL-SKMFKEEN 299 + E + +++ +P A V+ L K +K + Sbjct: 255 AYEAAVAEQVKELIEKLRLC--SPGFAASVETLWGKTYKRQK 294 >5AEL-A nrPDB Length = 367 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 47/282 (16%), Positives = 93/282 (32%), Gaps = 35/282 (12%) Query: 50 IEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDH- 108 + E L L+ DDI DNS RRG P + + + + ++ + Sbjct: 89 GWMIEFLQAHYLVEDDIMDNSVTRRGKPCWYRHPDVTVQCAINDGLLLKSWTHMMAMHFF 148 Query: 109 ------PDAVKLFTRQLLELHQGQGLDIYWR---------------DNYTCPTEEEYKAM 147 D + F R GQ D+ ++ T YK + Sbjct: 149 ADRPFLQDLLCRFNRVDYTTAVGQLYDVTSMFDSNKLDPDVSQPTTTDFAEFTLSNYKRI 208 Query: 148 VLQKTGGLFG-LAVGLMQLFSDYKEDL-----KPLLNTLGLFFQIRDDYANLHSKEYSEN 201 V KT L + + + S+ + + L +G +FQ++DD + + Sbjct: 209 VKYKTAYYTYLLPLVMGLIVSEALPTVDMGVTEELAMLMGEYFQVQDDVMDCFTPPERLG 268 Query: 202 KSFCEDLTEGKFSFPTIHAIWSRPE---STQVQNILRQRTENIDIKKYCVHYLEDVGSFE 258 K D+ + K S+ + + + N +E + + + G + Sbjct: 269 K-VGTDIQDAKCSWLAVTFLAKASSAQVAEFKANYGSGDSEKVATVRRLYEEADLQGDYV 327 Query: 259 YTRNTLKELEAKAYKQIDARGGNPELVALVKHL-SKMFKEEN 299 + E + +++ +P A V+ L K +K + Sbjct: 328 AYEAAVAEQVKELIEKLRLC--SPGFAASVETLWGKTYKRQK 367 >3ICK-A nrPDB Length = 362 Score = 116 bits (292), Expect = 9e-27, Method: Composition-based stats. Identities = 51/300 (17%), Positives = 96/300 (32%), Gaps = 43/300 (14%) Query: 22 LPGKQVRTKLS-------QAFNHWLKVPEDKLQIIIEV----TEMLHNASLLIDDIEDNS 70 L GK R A + ++++ V E L L+ DDI D S Sbjct: 45 LGGKYFRGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDIMDGS 104 Query: 71 KLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLT----LDHP---DAVKLFTRQLLELH 123 +RRG P + G+ + + + +++ D P D + LF + Sbjct: 105 VMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLKDLLCLFQKVDYATA 164 Query: 124 QGQGLDIYWR---------------DNYTCPTEEEYKAMVLQKTGG---LFGLAVGLM-- 163 GQ D+ ++ T YK +V KT L L +GL Sbjct: 165 VGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIYKRIVKYKTTFYTYLLPLVMGLFVS 224 Query: 164 -QLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIW 222 S ++ + + +G +FQ++DD + + K D+ + K S+ + + Sbjct: 225 EAAASVEMNLVERVAHLIGEYFQVQDDVMDCFTPPEQLGK-VGTDIEDAKCSWLAVTFLG 283 Query: 223 SRPE---STQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARG 279 + N + + + K F + +Q+ + Sbjct: 284 KANAAQVAEFKANYGDKDPAKVAVVKRLYSEANLQADFAAYEAEVVREVESLIEQLKVKS 343 >4JZB-A nrPDB Length = 362 Score = 115 bits (288), Expect = 2e-26, Method: Composition-based stats. Identities = 54/328 (16%), Positives = 102/328 (31%), Gaps = 42/328 (12%) Query: 13 LEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQII-----------IEVTEMLHNASL 61 L+ L GK R + + EML L Sbjct: 36 LKSMMDTTCLGGKYNRGLCVVDVAEAMAKDTQMDAAAMERVLHDACVCGWMIEMLQAHFL 95 Query: 62 LIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLD-------HPDAVKL 114 + DDI D+SK RRG P + G+ + + + + L + L + +++ Sbjct: 96 VEDDIMDHSKTRRGKPCWYLHPGVTAQVAINDGLILLAWATQMALHYFADRPFLAEVLRV 155 Query: 115 FTRQLLELHQGQGLDIYWR---------------DNYTCPTEEEYKAMVLQKTGGLFG-L 158 F L GQ D+ +Y T ++ +V+ KT L Sbjct: 156 FHDVDLTTTIGQLYDVTSMVDSAKLDAKVAHANTTDYVEYTPFNHRRIVVYKTAYYTYWL 215 Query: 159 AVGLMQLFSDYKEDL-----KPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKF 213 + + L S E + + +G +FQ++DD + + K D+ + K Sbjct: 216 PLVMGLLVSGTLEKVDKKATHKVAMVMGEYFQVQDDVMDCFTPPEKLGK-IGTDIEDAKC 274 Query: 214 SFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYK 273 S+ + + + P + + + + K + A+ + Sbjct: 275 SWLAVTFLTTAPAEKVAEFKANYGSTDPAAVAVIKQLYTEQNLLARFEEYEKAVVAEVEQ 334 Query: 274 QIDARGGNPELVALVKHL--SKMFKEEN 299 I A A + SK +K + Sbjct: 335 LIAALEAQNAAFAASVKVLWSKTYKRQK 362 >3KRO-B nrPDB Length = 274 Score = 63.4 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 28/192 (14%), Positives = 55/192 (28%), Gaps = 16/192 (8%) Query: 7 TVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDI 66 + P +L + L A + + ++H A+ + + + Sbjct: 23 RPPETVFGPMHHLTFAAPATAASTLCLAACELVGGDRSQAMAAAAAIHLVHAAAYVHEHL 82 Query: 67 EDNSKLRR-GFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHP---DAVKLFTRQLLEL 122 R P YG + + + + G E + P D R ++E+ Sbjct: 83 PLTDGSRPVSKPAIQHKYGPNVELLTGDGIVPFGFELLAGSVDPARTDDPDRILRVIIEI 142 Query: 123 HQ---------GQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDL 173 + G + D T EY + +K G + + E+ Sbjct: 143 SRAGGPEGMISGLHREEEIVDGNTSLDFIEY--VCKKKYGEMHACGAACGAILGGAAEEE 200 Query: 174 KPLLNTLGLFFQ 185 L GL +Q Sbjct: 201 IQKLRNFGL-YQ 211 >3QKC-B nrPDB Length = 273 Score = 55.7 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 26/181 (14%), Positives = 53/181 (29%), Gaps = 11/181 (6%) Query: 12 LLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIE-DNS 70 + EP +L + + L A + ++H A+ +++ + Sbjct: 33 VFEPMHHLTFAAPRTSASALCVAACELVGGDRSDAMAAAAAVHLMHVAAYTHENLPLTDG 92 Query: 71 KLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHP--DAVKLFTRQLLEL-----H 123 + + + + + + GLE + P + R ++EL Sbjct: 93 PM--SKSEIQHKFDPNIELLTGDGIIPFGLELMARSMDPTRNNPDRILRAIIELTRVMGS 150 Query: 124 QGQGLDIYWRDNYTCPTEEEYKAMV-LQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGL 182 +G Y + E V +K G L + ED L GL Sbjct: 151 EGIVEGQYHELGLNQLNDLELIEYVCKKKEGTLHACGAACGAILGGCDEDKIEKLRRFGL 210 Query: 183 F 183 + Sbjct: 211 Y 211 >3QD2-B nrPDB Length = 332 Score = 32.6 bits (73), Expect = 0.21, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 27/79 (34%), Gaps = 14/79 (17%) Query: 49 IIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDH 108 I E E LH+ L+ D+ P + + + V+ ++ +++ D Sbjct: 173 IAEAVEFLHSKGLMHRDL---------KPS-NIFFTMDDVVKVGDFGLVTAMDQ----DE 218 Query: 109 PDAVKLFTRQLLELHQGQG 127 + L H GQ Sbjct: 219 EEQTVLTPMPAYATHTGQV 237 >4M7I-A nrPDB Length = 299 Score = 31.9 bits (71), Expect = 0.38, Method: Composition-based stats. Identities = 9/57 (15%), Positives = 21/57 (36%), Gaps = 10/57 (17%) Query: 46 LQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEK 102 I E E LH+ L+ D+ P + + + V+ ++ +++ Sbjct: 124 FLQIAEAVEFLHSKGLMHRDL---------KPS-NIFFTMDDVVKVGDFGLVTAMDQ 170 >5H05-A nrPDB Length = 640 Score = 30.3 bits (67), Expect = 1.0, Method: Composition-based stats. Identities = 33/185 (17%), Positives = 55/185 (29%), Gaps = 28/185 (15%) Query: 129 DIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQ---LFSDYKEDLKPLLNTL----- 180 D+ R N P + EY K F A + ++L+ + Sbjct: 304 DLLQRGNIASPEQAEYWE--RHKAALSFQAAYSGPITLYYGEEIGDELEGYAQKVEQDCA 361 Query: 181 --GLFFQIRDDYA-----NLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNI 233 GL DD+ N+ + N+ DL + T+ A + NI Sbjct: 362 VQGLC----DDHVARTSANIDGLTVNLNEKQ-RDLKQYVSQLMTLRAAHPALSRGERTNI 416 Query: 234 LRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSK 293 + T ID K+ D + Y +T + + K D + L + Sbjct: 417 VANETVYIDHKQA------DDDALIYMVSTTADQDTVELKASDIASDGQLVDLLTGKVHS 470 Query: 294 MFKEE 298 E Sbjct: 471 AINGE 475 >4FYU-A nrPDB Length = 145 Score = 28.0 bits (61), Expect = 4.5, Method: Composition-based stats. Identities = 15/78 (19%), Positives = 28/78 (35%), Gaps = 2/78 (2%) Query: 191 ANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHY 250 +L + + K D K + P Q IL++ E +D ++ + + Sbjct: 8 IDLKKADGTVKK--GSDALANKKVVALYFSAHWCPPCRQFTPILKEFYEEVDDDQFEIVF 65 Query: 251 LEDVGSFEYTRNTLKELE 268 + S E N +KE Sbjct: 66 VSLDHSEEDLNNYVKESH 83 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.315 0.144 0.390 Lambda K H 0.267 0.0439 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 11,634,873 Number of Sequences: 36641 Number of extensions: 482168 Number of successful extensions: 1754 Number of sequences better than 10.0: 81 Number of HSP's better than 10.0 without gapping: 113 Number of HSP's successfully gapped in prelim test: 41 Number of HSP's that attempted gapping in prelim test: 1344 Number of HSP's gapped (non-prelim): 165 length of query: 300 length of database: 10,336,785 effective HSP length: 97 effective length of query: 203 effective length of database: 6,782,608 effective search space: 1376869424 effective search space used: 1376869424 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 59 (27.2 bits)