BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= O75832 (226 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4NIK-A nrPDB 464 e-131 2DWZ-A nrPDB 446 e-126 1WG0-A nrPDB 114 3e-26 3B7B-A nrPDB 101 3e-22 5AQ9-A nrPDB 100 4e-22 6BY9-A nrPDB 100 5e-22 5JHQ-A nrPDB 100 7e-22 5AQB-A nrPDB 98 2e-21 5AQA-A nrPDB 97 6e-21 6MWQ-A nrPDB 96 1e-20 5AQ7-A nrPDB 95 3e-20 5H76-A nrPDB 94 5e-20 6FES-A nrPDB 89 1e-18 5MIO-C nrPDB 88 3e-18 5HKP-A nrPDB 87 4e-18 6AUN-A nrPDB 84 4e-17 4OT9-A nrPDB 80 7e-16 4Z68-A nrPDB 80 9e-16 5CBO-A nrPDB 78 3e-15 3EU9-A nrPDB 77 6e-15 5ET1-A nrPDB 75 2e-14 5GP7-A nrPDB 74 7e-14 3ZKJ-A nrPDB 69 2e-12 4OAU-C nrPDB 67 7e-12 1G3N-B nrPDB 65 2e-11 5D68-A nrPDB 60 1e-09 4O1O-A nrPDB 59 2e-09 5DND-A nrPDB 58 4e-09 6EMK-G nrPDB 57 6e-09 3EHQ-A nrPDB 54 5e-08 2KXP-C nrPDB 52 3e-07 5U0J-A nrPDB 49 2e-06 1BD8-A nrPDB 48 3e-06 5U0K-A nrPDB 48 3e-06 5UQE-A nrPDB 47 5e-06 3LJN-A nrPDB 47 5e-06 1BLX-B nrPDB 47 7e-06 5UIL-A nrPDB 47 9e-06 3T9K-A nrPDB 46 1e-05 6BOA-A nrPDB 44 5e-05 3UI2-A nrPDB 44 6e-05 1DCQ-A nrPDB 44 6e-05 3DEO-A nrPDB 43 9e-05 4XD0-A nrPDB 43 1e-04 6E2G-A nrPDB 40 6e-04 6DMR-A nrPDB 39 0.002 4BSZ-B nrPDB 39 0.002 2RFA-A nrPDB 39 0.003 2A5E-A nrPDB 35 0.026 5IRX-A nrPDB 33 0.074 1D9S-A nrPDB 33 0.078 4GMM-A nrPDB 33 0.13 2NYJ-A nrPDB 33 0.13 3I5Q-B nrPDB 33 0.13 3I5P-A nrPDB 32 0.15 2B0O-E nrPDB 32 0.15 3LVQ-E nrPDB 32 0.16 6DVZ-A nrPDB 32 0.21 6OO7-A nrPDB 31 0.43 6G1K-A nrPDB 30 0.84 4N5Q-A nrPDB 30 1.1 6C8G-A nrPDB 29 2.0 6BBJ-A nrPDB 28 3.5 6BO5-A nrPDB 28 3.9 5HI9-A nrPDB 28 3.9 5AN8-A nrPDB 28 3.9 2ZCI-A nrPDB 28 4.6 3W9G-A nrPDB 27 7.1 6HEG-A nrPDB 27 9.4 6MHW-A nrPDB 27 9.7 >4NIK-A nrPDB Length = 230 Score = 464 bits (1193), Expect = e-131, Method: Compositional matrix adjust. Identities = 226/226 (100%), Positives = 226/226 (100%) Query: 1 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL Sbjct: 5 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 64 Query: 61 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 120 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE Sbjct: 65 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 124 Query: 121 IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC 180 IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC Sbjct: 125 IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC 184 Query: 181 DEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG 226 DEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG Sbjct: 185 DEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG 230 >2DWZ-A nrPDB Length = 231 Score = 446 bits (1147), Expect = e-126, Method: Compositional matrix adjust. Identities = 213/226 (94%), Positives = 221/226 (97%) Query: 1 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60 MEGCVSN+M+CNLAYSGKL+ELKE ILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL Sbjct: 1 MEGCVSNIMICNLAYSGKLDELKERILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60 Query: 61 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 120 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL KGA VNAVNQNGCTPLHYAASKNRHE Sbjct: 61 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLVKGAHVNAVNQNGCTPLHYAASKNRHE 120 Query: 121 IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC 180 IAVMLLEGGANPDAKDHY+ATAMHRAAAKGNLKM+HILL+YKASTNIQDTEGNTPLHLAC Sbjct: 121 IAVMLLEGGANPDAKDHYDATAMHRAAAKGNLKMVHILLFYKASTNIQDTEGNTPLHLAC 180 Query: 181 DEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG 226 DEERVEEAK LV+QGASIYIENKEEKTPLQVAKGGLGLILKR+ EG Sbjct: 181 DEERVEEAKFLVTQGASIYIENKEEKTPLQVAKGGLGLILKRLAEG 226 >1WG0-A nrPDB Length = 243 Score = 114 bits (286), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 75/210 (35%), Positives = 111/210 (52%), Gaps = 8/210 (3%) Query: 5 VSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGV 64 +SN + + +++E + + SL + DQD R LHW+ S EI FLL Sbjct: 1 MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME 60 Query: 65 PVN---DKDDAGWSPLHIAASAGRDEIVKALLGKGAQ--VNAVNQNGCTPLHYAASKNRH 119 VN DD+GW+P HIA S G E+VK+L + + +N + G T LH A K Sbjct: 61 NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWF 120 Query: 120 EIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILL-YYKASTNIQDTEGNTPLHL 178 E++ L+E GA+ KD + +HRAA+ G+LK+I +L K++ N QD +G TPL Sbjct: 121 EVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFH 180 Query: 179 ACDEERVEEAKLLVSQGASIY--IENKEEK 206 A E + A LLV + + Y ++NK K Sbjct: 181 ALAEGHGDAAVLLVEKYGAEYDLVDNKGAK 210 Score = 62.0 bits (149), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 50/152 (32%), Positives = 74/152 (48%), Gaps = 8/152 (5%) Query: 76 PLHIAASAGRDEIVKALL-GKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134 PLH A V+ LL K + + +Q+G PLH++ S HEI LL N + Sbjct: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 Query: 135 KDHYE---ATAMHRAAAKGNLKMIHILL--YYKASTNIQDTEGNTPLHLACDEERVEEAK 189 D+ + T H A + GNL+++ L K N +G T LHLA ++ E ++ Sbjct: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 Query: 190 LLVSQGASIYIENKEEKTPLQVAK--GGLGLI 219 L+ GAS+ I++K + PL A G L LI Sbjct: 125 FLIENGASVRIKDKFNQIPLHRAASVGSLKLI 156 >3B7B-A nrPDB Length = 237 Score = 101 bits (251), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 60/176 (34%), Positives = 97/176 (55%), Gaps = 1/176 (0%) Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGA 97 +D RT L A H E V++L++ G V+ KD G + LH+AA G E+V+ LL G Sbjct: 42 EDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQ 101 Query: 98 -QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156 VN + G TP+ +A ++ +LL G++ + +D+ E +H AA G + + Sbjct: 102 MDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAE 161 Query: 157 ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212 ILL K + + G++PLH+A E R + L +S+ + + ++NKE +TPLQ A Sbjct: 162 ILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 217 Score = 80.5 bits (197), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 52/139 (37%), Positives = 76/139 (54%), Gaps = 1/139 (0%) Query: 75 SPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134 SPLH AA AG +I L+ GA ++ +++ TPL AA N E L++ GA D Sbjct: 13 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDP 72 Query: 135 KDHYEATAMHRAAAKGNLKMIHILLYY-KASTNIQDTEGNTPLHLACDEERVEEAKLLVS 193 KD +T +H AA KG+ +++ LL + N QD G TP+ A + + V+ KLL+S Sbjct: 73 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLS 132 Query: 194 QGASIYIENKEEKTPLQVA 212 +G+ I I + EE L A Sbjct: 133 KGSDINIRDNEENICLHWA 151 Score = 63.2 bits (152), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 47/147 (31%), Positives = 68/147 (46%), Gaps = 35/147 (23%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLG-VPVNDKDDA 72 A + LE +K I A +L D + T LH A GH E+V++LL G + VN +DD Sbjct: 52 AENNHLEAVKYLIKA-GALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDG 110 Query: 73 GWSPLHIAASAGRDEIVKALLGKGAQVN-------------------------------- 100 GW+P+ A ++VK LL KG+ +N Sbjct: 111 GWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDL 170 Query: 101 -AVNQNGCTPLHYAASKNRHEIAVMLL 126 AVN +G +PLH AA +NR++ V+ L Sbjct: 171 HAVNIHGDSPLHIAARENRYDCVVLFL 197 Score = 50.4 bits (119), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 32/93 (34%), Positives = 49/93 (52%) Query: 103 NQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK 162 +QN +PLH AA +I ML++ GAN D + T + AA +L+ + L+ Sbjct: 8 HQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAG 67 Query: 163 ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQG 195 A + +D EG+T LHLA + E + L+S G Sbjct: 68 ALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNG 100 >5AQ9-A nrPDB Length = 422 Score = 100 bits (250), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 55/133 (41%), Positives = 80/133 (60%) Query: 80 AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139 AA AG+D+ V+ L+ GA VNA + G TPLH AA EI +LL+ GA+ DA D + Sbjct: 21 AARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVFG 80 Query: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199 T +H AA G+L+++ +LL A N D++G TPLHLA +E ++L+ GA + Sbjct: 81 YTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEIVEVLLKHGADVN 140 Query: 200 IENKEEKTPLQVA 212 ++K KTP +A Sbjct: 141 AQDKFGKTPFDLA 153 Score = 96.7 bits (239), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 60/145 (41%), Positives = 80/145 (55%) Query: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNG 106 A AG + V L+ G VN D+ G +PLH+AA +G EIV+ LL GA V+A + G Sbjct: 21 AARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVFG 80 Query: 107 CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTN 166 TPLH AA EI +LL+ GA+ +A D T +H AA G L+++ +LL + A N Sbjct: 81 YTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEIVEVLLKHGADVN 140 Query: 167 IQDTEGNTPLHLACDEERVEEAKLL 191 QD G TP LA D + LL Sbjct: 141 AQDKFGKTPFDLADDNGNDDVGTLL 165 Score = 91.7 bits (226), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 56/138 (40%), Positives = 81/138 (58%), Gaps = 1/138 (0%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73 A +G+ +E++ ++A+ + D T LH A +GH EIVE LL+ G V+ D G Sbjct: 22 ARAGQDDEVR-ILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVFG 80 Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133 ++PLH+AA G EIV+ LL GA VNA++ +G TPLH AA EI +LL+ GA+ + Sbjct: 81 YTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEIVEVLLKHGADVN 140 Query: 134 AKDHYEATAMHRAAAKGN 151 A+D + T A GN Sbjct: 141 AQDKFGKTPFDLADDNGN 158 Score = 73.2 bits (178), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 47/112 (41%), Positives = 60/112 (53%), Gaps = 1/112 (0%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73 AYSG LE + E +L + +D T LH A GH EIVE LL+ G VN D G Sbjct: 55 AYSGHLE-IVEVLLKHGADVDASDVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDG 113 Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125 +PLH+AA G EIV+ LL GA VNA ++ G TP A ++ +L Sbjct: 114 MTPLHLAAKWGYLEIVEVLLKHGADVNAQDKFGKTPFDLADDNGNDDVGTLL 165 >6BY9-A nrPDB Length = 328 Score = 100 bits (249), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 60/176 (34%), Positives = 97/176 (55%), Gaps = 1/176 (0%) Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGA 97 +D RT L A H E V++L++ G V+ KD G + LH+AA G E+V+ LL G Sbjct: 133 EDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQ 192 Query: 98 -QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156 VN + G TP+ +A ++ +LL G++ + +D+ E +H AA G + + Sbjct: 193 MDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAE 252 Query: 157 ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212 ILL K + + G++PLH+A E R + L +S+ + + ++NKE +TPLQ A Sbjct: 253 ILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 308 Score = 80.9 bits (198), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 63/196 (32%), Positives = 99/196 (50%), Gaps = 3/196 (1%) Query: 20 EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK--DDAGWSPL 77 E L+ +++A S + + L+++ G + V +L G+ N K SPL Sbjct: 47 ETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPL 106 Query: 78 HIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDH 137 H AA AG +I L+ GA ++ +++ TPL AA N E L++ GA D KD Sbjct: 107 HAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDA 166 Query: 138 YEATAMHRAAAKGNLKMIHILLYY-KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGA 196 +T +H AA KG+ +++ LL + N QD G TP+ A + + V+ KLL+S+G+ Sbjct: 167 EGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGS 226 Query: 197 SIYIENKEEKTPLQVA 212 I I + EE L A Sbjct: 227 DINIRDNEENICLHWA 242 Score = 62.8 bits (151), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 47/147 (31%), Positives = 68/147 (46%), Gaps = 35/147 (23%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLG-VPVNDKDDA 72 A + LE +K I A +L D + T LH A GH E+V++LL G + VN +DD Sbjct: 143 AENNHLEAVKYLIKA-GALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDG 201 Query: 73 GWSPLHIAASAGRDEIVKALLGKGAQVN-------------------------------- 100 GW+P+ A ++VK LL KG+ +N Sbjct: 202 GWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDL 261 Query: 101 -AVNQNGCTPLHYAASKNRHEIAVMLL 126 AVN +G +PLH AA +NR++ V+ L Sbjct: 262 HAVNIHGDSPLHIAARENRYDCVVLFL 288 >5JHQ-A nrPDB Length = 482 Score = 100 bits (248), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 75/232 (32%), Positives = 111/232 (47%), Gaps = 33/232 (14%) Query: 14 AYSGKLEELKESI----------LADKSLATRTDQDSR--TALHWACSAGHTEIVEFLLQ 61 A SG L EL E+ L D + D R + LH+A G ++VE LLQ Sbjct: 11 AVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQ 70 Query: 62 LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEI 121 +G V+ +DD G PLH A S G E+V LL +GA NA + TPLH AA K + ++ Sbjct: 71 MGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDV 130 Query: 122 AVMLLEGGANPDAKD--------------------HYEATAMHRAAAKGN-LKMIHILLY 160 ++LL+ GA+P+ ++ Y+ + AA GN K++ +L Sbjct: 131 CIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTP 190 Query: 161 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212 + + D +TPLHLA RV +LL+ GA ++ ++K PL A Sbjct: 191 LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNA 242 Score = 85.9 bits (211), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 68/201 (33%), Positives = 96/201 (47%), Gaps = 24/201 (11%) Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95 +D T LH A IV+ LLQ G V+ KD G PLH A S G E+ + LL Sbjct: 198 SDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKH 257 Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP--------DAKD----------- 136 GA VNA++ TPLH AASKNR E+ +LL GA+P A D Sbjct: 258 GACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERL 317 Query: 137 --HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC---DEERVEEAKLL 191 ++ ++ +AA + +L + L + Q T LH A +R + +LL Sbjct: 318 TYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELL 377 Query: 192 VSQGASIYIENKEEKTPLQVA 212 + +GA++ +NK+ TPL VA Sbjct: 378 LRKGANVNEKNKDFMTPLHVA 398 Score = 80.1 bits (196), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 68/223 (30%), Positives = 93/223 (41%), Gaps = 54/223 (24%) Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL---------- 93 LH ACS GH E+V LL G N +D+ ++PLH AA G+ ++ LL Sbjct: 86 LHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRN 145 Query: 94 --GKGA----------------------------------------QVNAVNQNG--CTP 109 GK A VN +G TP Sbjct: 146 TDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTP 205 Query: 110 LHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQD 169 LH AA NR I +LL+ GA+ AKD +H A + G+ ++ +LL + A N D Sbjct: 206 LHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMD 265 Query: 170 TEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212 TPLH A + RVE LL+S GA + N K+ + +A Sbjct: 266 LWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 308 Score = 71.6 bits (174), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 53/163 (32%), Positives = 85/163 (52%), Gaps = 2/163 (1%) Query: 27 LADKSL-ATRTDQDSRTALHWACSAGHTE-IVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84 LAD S A T + + L A +G+ E ++ L L V + D +PLH+AA Sbjct: 154 LADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYN 213 Query: 85 RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144 R IV+ LL GA V+A ++ G PLH A S +E+ +LL+ GA +A D ++ T +H Sbjct: 214 RVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLH 273 Query: 145 RAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEE 187 AA+K +++ +LL + A + + G + + +A E E Sbjct: 274 EAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRER 316 Score = 59.7 bits (143), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 34/90 (37%), Positives = 53/90 (58%) Query: 85 RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144 R ++ + LL KGA VN N++ TPLH AA + +++ +L + GA +A D TA+H Sbjct: 370 RKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALH 429 Query: 145 RAAAKGNLKMIHILLYYKASTNIQDTEGNT 174 RAA G+L+ +LL Y + +I +G T Sbjct: 430 RAALAGHLQTCRLLLSYGSDPSIISLQGFT 459 Score = 58.5 bits (140), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 39/122 (31%), Positives = 68/122 (55%), Gaps = 4/122 (3%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHT---EIVEFLLQLGVPVNDKD 70 A L ++K++ LA + + + Q TALH A ++ H ++ E LL+ G VN+K+ Sbjct: 330 AREADLAKVKKT-LALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKN 388 Query: 71 DAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA 130 +PLH+AA +++++ L GA++NA++ G T LH AA + +LL G+ Sbjct: 389 KDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGS 448 Query: 131 NP 132 +P Sbjct: 449 DP 450 Score = 53.5 bits (127), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 63/241 (26%), Positives = 94/241 (39%), Gaps = 57/241 (23%) Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAA------------SAG 84 D+ LH ACS GH E+ E LL+ G VN D ++PLH AA S G Sbjct: 232 DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHG 291 Query: 85 RDEIVKALLGKGA--------------------------------------QVNAVN--- 103 D + GK A + +N Sbjct: 292 ADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQ 351 Query: 104 -QNGCTPLHYAASK---NRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILL 159 Q+ T LH A + R ++ +LL GAN + K+ T +H AA + + ++ +L Sbjct: 352 PQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLH 411 Query: 160 YYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLI 219 + A N DT G T LH A ++ +LL+S G+ I + + T Q+ + I Sbjct: 412 KHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQI 471 Query: 220 L 220 L Sbjct: 472 L 472 Score = 41.6 bits (96), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 26/91 (28%), Positives = 45/91 (49%) Query: 18 KLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPL 77 K +++ E +L + ++D T LH A H +++E L + G +N D G + L Sbjct: 369 KRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTAL 428 Query: 78 HIAASAGRDEIVKALLGKGAQVNAVNQNGCT 108 H AA AG + + LL G+ + ++ G T Sbjct: 429 HRAALAGHLQTCRLLLSYGSDPSIISLQGFT 459 >5AQB-A nrPDB Length = 428 Score = 98.2 bits (243), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 61/145 (42%), Positives = 82/145 (56%), Gaps = 1/145 (0%) Query: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNG 106 A AG + L+ G VN D+ GW+PLH+AA G EIV+ LL GA VNA + +G Sbjct: 21 AARAGQDDECRILMANGADVNALDEVGWTPLHLAAW-GHLEIVECLLKNGADVNAADIDG 79 Query: 107 CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTN 166 TPLH AA EI +LL+ GA+ +A D T +H AA G+L+++ +LL A N Sbjct: 80 YTPLHLAAFSGHLEIVEVLLKYGADVNADDQAGFTPLHLAAIFGHLEIVEVLLKNGADVN 139 Query: 167 IQDTEGNTPLHLACDEERVEEAKLL 191 QD G TP LA D + A++L Sbjct: 140 AQDKFGKTPRDLAIDNGNEDIAEVL 164 Score = 88.6 bits (218), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 54/133 (40%), Positives = 79/133 (59%), Gaps = 1/133 (0%) Query: 80 AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139 AA AG+D+ + L+ GA VNA+++ G TPLH AA + EI LL+ GA+ +A D Sbjct: 21 AARAGQDDECRILMANGADVNALDEVGWTPLHLAAWGHL-EIVECLLKNGADVNAADIDG 79 Query: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199 T +H AA G+L+++ +LL Y A N D G TPLHLA +E ++L+ GA + Sbjct: 80 YTPLHLAAFSGHLEIVEVLLKYGADVNADDQAGFTPLHLAAIFGHLEIVEVLLKNGADVN 139 Query: 200 IENKEEKTPLQVA 212 ++K KTP +A Sbjct: 140 AQDKFGKTPRDLA 152 Score = 87.0 bits (214), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 71/194 (36%), Positives = 98/194 (50%), Gaps = 14/194 (7%) Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96 D+ T LH A + GH EIVE LL+ G VN D G++PLH+AA +G EIV+ LL G Sbjct: 44 DEVGWTPLHLA-AWGHLEIVECLLKNGADVNAADIDGYTPLHLAAFSGHLEIVEVLLKYG 102 Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156 A VNA +Q G TPLH AA EI +LL+ GA+ +A+D + T A GN + Sbjct: 103 ADVNADDQAGFTPLHLAAIFGHLEIVEVLLKNGADVNAQDKFGKTPRDLAIDNGNEDIAE 162 Query: 157 ILLYYKASTNIQDTEGNTPLHLACDE--ERVEEAKLLVSQGASIYIENKEEKTPLQVAKG 214 +L ++D A D+ RV +L ++ G + EE+ P+ Sbjct: 163 VLGKAATLVKVKD---------AADQLGARVGYIELDLNSGKILESFRSEERFPMMSTFK 213 Query: 215 GL--GLILKRMVEG 226 L G IL R+ G Sbjct: 214 VLLAGAILSRIDAG 227 Score = 78.6 bits (192), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 50/115 (43%), Positives = 65/115 (56%), Gaps = 1/115 (0%) Query: 11 CNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKD 70 +LA G LE + E +L + + D D T LH A +GH EIVE LL+ G VN D Sbjct: 51 LHLAAWGHLE-IVECLLKNGADVNAADIDGYTPLHLAAFSGHLEIVEVLLKYGADVNADD 109 Query: 71 DAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125 AG++PLH+AA G EIV+ LL GA VNA ++ G TP A +IA +L Sbjct: 110 QAGFTPLHLAAIFGHLEIVEVLLKNGADVNAQDKFGKTPRDLAIDNGNEDIAEVL 164 >5AQA-A nrPDB Length = 418 Score = 97.1 bits (240), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 55/133 (41%), Positives = 79/133 (59%) Query: 80 AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139 AA AG+D+ V+ L+ GA VNA + G TPLH AA EI +LL+ GA+ DA D + Sbjct: 21 AARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVFG 80 Query: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199 T +H AA G+L+++ +LL A N D++G TPLHLA E ++L+ GA + Sbjct: 81 YTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYKEIVEVLLKAGADVD 140 Query: 200 IENKEEKTPLQVA 212 ++K K PL +A Sbjct: 141 AQDKFGKRPLWLA 153 Score = 94.0 bits (232), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 56/138 (40%), Positives = 83/138 (60%), Gaps = 1/138 (0%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73 A +G+ +E++ ++A+ + D T LH A +GH EIVE LL+ G V+ D G Sbjct: 22 ARAGQDDEVR-ILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVFG 80 Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133 ++PLH+AA G EIV+ LL GA VNA++ +G TPLH AA EI +LL+ GA+ D Sbjct: 81 YTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYKEIVEVLLKAGADVD 140 Query: 134 AKDHYEATAMHRAAAKGN 151 A+D + + AA +G+ Sbjct: 141 AQDKFGKRPLWLAADQGH 158 Score = 94.0 bits (232), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 60/147 (40%), Positives = 81/147 (55%) Query: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNG 106 A AG + V L+ G VN D+ G +PLH+AA +G EIV+ LL GA V+A + G Sbjct: 21 AARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVFG 80 Query: 107 CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTN 166 TPLH AA EI +LL+ GA+ +A D T +H AA G +++ +LL A + Sbjct: 81 YTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYKEIVEVLLKAGADVD 140 Query: 167 IQDTEGNTPLHLACDEERVEEAKLLVS 193 QD G PL LA D+ E A LV+ Sbjct: 141 AQDKFGKRPLWLAADQGHAEIAAKLVA 167 Score = 75.5 bits (184), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 50/113 (44%), Positives = 63/113 (55%), Gaps = 1/113 (0%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73 AYSG LE + E +L + +D T LH A GH EIVE LL+ G VN D G Sbjct: 55 AYSGHLE-IVEVLLKHGADVDASDVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDG 113 Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLL 126 +PLH+AA G EIV+ LL GA V+A ++ G PL AA + EIA L+ Sbjct: 114 MTPLHLAAKWGYKEIVEVLLKAGADVDAQDKFGKRPLWLAADQGHAEIAAKLV 166 >6MWQ-A nrPDB Length = 493 Score = 95.9 bits (237), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 52/133 (39%), Positives = 81/133 (60%) Query: 80 AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139 AA AG+D+ V+ L+ GA VNA+++ G TPLH AA + EI +LL+ GA+ +A D + Sbjct: 12 AARAGQDDEVRILMANGADVNALDRFGLTPLHLAAQRGHLEIVEVLLKCGADVNAADLWG 71 Query: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199 T +H AA G+L+++ +LL Y A N D G TPLHL + +E ++L+ GA + Sbjct: 72 QTPLHLAATAGHLEIVEVLLKYGADVNALDLIGKTPLHLTAIDGHLEIVEVLLKHGADVN 131 Query: 200 IENKEEKTPLQVA 212 ++K KT ++ Sbjct: 132 AQDKFGKTAFDIS 144 Score = 92.8 bits (229), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 73/192 (38%), Positives = 98/192 (51%), Gaps = 5/192 (2%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73 A +G+ +E++ ++A+ + D+ T LH A GH EIVE LL+ G VN D G Sbjct: 13 ARAGQDDEVR-ILMANGADVNALDRFGLTPLHLAAQRGHLEIVEVLLKCGADVNAADLWG 71 Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133 +PLH+AA+AG EIV+ LL GA VNA++ G TPLH A EI +LL+ GA+ + Sbjct: 72 QTPLHLAATAGHLEIVEVLLKYGADVNALDLIGKTPLHLTAIDGHLEIVEVLLKHGADVN 131 Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVS 193 A+D + TA + GN + IL S LA DE AK L S Sbjct: 132 AQDKFGKTAFDISIDNGNEDLAEILQKLNLSDIAHRIVAPGKGILAADESTGSIAKRLQS 191 Query: 194 QGASIYIENKEE 205 G EN EE Sbjct: 192 IGT----ENTEE 199 Score = 90.5 bits (223), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 57/145 (39%), Positives = 80/145 (55%) Query: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNG 106 A AG + V L+ G VN D G +PLH+AA G EIV+ LL GA VNA + G Sbjct: 12 AARAGQDDEVRILMANGADVNALDRFGLTPLHLAAQRGHLEIVEVLLKCGADVNAADLWG 71 Query: 107 CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTN 166 TPLH AA+ EI +LL+ GA+ +A D T +H A G+L+++ +LL + A N Sbjct: 72 QTPLHLAATAGHLEIVEVLLKYGADVNALDLIGKTPLHLTAIDGHLEIVEVLLKHGADVN 131 Query: 167 IQDTEGNTPLHLACDEERVEEAKLL 191 QD G T ++ D + A++L Sbjct: 132 AQDKFGKTAFDISIDNGNEDLAEIL 156 >5AQ7-A nrPDB Length = 418 Score = 94.7 bits (234), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 60/147 (40%), Positives = 79/147 (53%) Query: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNG 106 A AG + V LL G VN D+ G++PLH+AA G IV+ LL GA VNA ++ G Sbjct: 21 AARAGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNANDERG 80 Query: 107 CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTN 166 TPLH AA EI +LL+ GA +A D +H AA G +++ +LL A + Sbjct: 81 HTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGYKEIVEVLLKAGADVD 140 Query: 167 IQDTEGNTPLHLACDEERVEEAKLLVS 193 QD G PL LA D+ E A LV+ Sbjct: 141 AQDKFGKRPLWLAADQGHAEIAAKLVA 167 Score = 87.4 bits (215), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 56/138 (40%), Positives = 79/138 (57%), Gaps = 1/138 (0%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73 A +G+ +E++ +LA+ + D+ T LH A GH IVE LL+ G VN D+ G Sbjct: 22 ARAGQDDEVR-ILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNANDERG 80 Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133 +PLH+AA G EIV+ LL GA VNA + G PLH AA EI +LL+ GA+ D Sbjct: 81 HTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGYKEIVEVLLKAGADVD 140 Query: 134 AKDHYEATAMHRAAAKGN 151 A+D + + AA +G+ Sbjct: 141 AQDKFGKRPLWLAADQGH 158 Score = 87.0 bits (214), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 52/133 (39%), Positives = 75/133 (56%) Query: 80 AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139 AA AG+D+ V+ LL GA VN ++ G TPLH AA + I +LL+ GA+ +A D Sbjct: 21 AARAGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNANDERG 80 Query: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199 T +H AA G+L+++ +LL A N D G PLHLA E ++L+ GA + Sbjct: 81 HTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGYKEIVEVLLKAGADVD 140 Query: 200 IENKEEKTPLQVA 212 ++K K PL +A Sbjct: 141 AQDKFGKRPLWLA 153 Score = 70.9 bits (172), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 47/113 (41%), Positives = 62/113 (54%), Gaps = 1/113 (0%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73 A+ G L + E +L + + D+ T LH A GH EIVE LL+ G VN D G Sbjct: 55 AWEGHLG-IVEVLLKNGADVNANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIG 113 Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLL 126 +PLH+AA G EIV+ LL GA V+A ++ G PL AA + EIA L+ Sbjct: 114 TAPLHLAAMWGYKEIVEVLLKAGADVDAQDKFGKRPLWLAADQGHAEIAAKLV 166 >5H76-A nrPDB Length = 201 Score = 94.0 bits (232), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 59/149 (39%), Positives = 87/149 (58%), Gaps = 2/149 (1%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73 A +G+ +E++ ++A+ + D T LH A +GH EIVE LL+ G V+ D G Sbjct: 14 ARAGQDDEVR-ILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVFG 72 Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133 ++PLH+AA G EIV+ LL GA VNA++ +G TPLH AA EI +LL+ GA + Sbjct: 73 YTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEIVEVLLKHGA-VN 131 Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYK 162 A+D + TA + GN + IL +Y+ Sbjct: 132 AQDKFGKTAFDISIDNGNEDLAQILAFYE 160 Score = 91.3 bits (225), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 53/133 (39%), Positives = 79/133 (59%), Gaps = 1/133 (0%) Query: 80 AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139 AA AG+D+ V+ L+ GA VNA + G TPLH AA EI +LL+ GA+ DA D + Sbjct: 13 AARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVFG 72 Query: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199 T +H AA G+L+++ +LL A N D++G TPLHLA +E ++L+ GA + Sbjct: 73 YTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEIVEVLLKHGA-VN 131 Query: 200 IENKEEKTPLQVA 212 ++K KT ++ Sbjct: 132 AQDKFGKTAFDIS 144 Score = 87.8 bits (216), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 57/145 (39%), Positives = 81/145 (55%), Gaps = 1/145 (0%) Query: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNG 106 A AG + V L+ G VN D+ G +PLH+AA +G EIV+ LL GA V+A + G Sbjct: 13 AARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASDVFG 72 Query: 107 CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTN 166 TPLH AA EI +LL+ GA+ +A D T +H AA G L+++ +LL + A N Sbjct: 73 YTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEIVEVLLKHGA-VN 131 Query: 167 IQDTEGNTPLHLACDEERVEEAKLL 191 QD G T ++ D + A++L Sbjct: 132 AQDKFGKTAFDISIDNGNEDLAQIL 156 >6FES-A nrPDB Length = 367 Score = 89.4 bits (220), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 56/135 (41%), Positives = 73/135 (54%) Query: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNG 106 A AG + V LL G VN D+ G++PLH+AA G IV+ LL GA VNA ++ G Sbjct: 13 AARAGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNANDERG 72 Query: 107 CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTN 166 TPLH AA EI +LL+ GA +A D +H AA G+ +++ +LL A Sbjct: 73 HTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGHEEIVEVLLKNGADAR 132 Query: 167 IQDTEGNTPLHLACD 181 QD G TP LA D Sbjct: 133 AQDKFGKTPEDLARD 147 Score = 85.1 bits (209), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 52/134 (38%), Positives = 75/134 (55%) Query: 80 AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139 AA AG+D+ V+ LL GA VN ++ G TPLH AA + I +LL+ GA+ +A D Sbjct: 13 AARAGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNANDERG 72 Query: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199 T +H AA G+L+++ +LL A N D G PLHLA E ++L+ GA Sbjct: 73 HTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGHEEIVEVLLKNGADAR 132 Query: 200 IENKEEKTPLQVAK 213 ++K KTP +A+ Sbjct: 133 AQDKFGKTPEDLAR 146 Score = 84.7 bits (208), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 53/128 (41%), Positives = 73/128 (57%), Gaps = 1/128 (0%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73 A +G+ +E++ +LA+ + D+ T LH A GH IVE LL+ G VN D+ G Sbjct: 14 ARAGQDDEVR-ILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNANDERG 72 Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133 +PLH+AA G EIV+ LL GA VNA + G PLH AA EI +LL+ GA+ Sbjct: 73 HTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGHEEIVEVLLKNGADAR 132 Query: 134 AKDHYEAT 141 A+D + T Sbjct: 133 AQDKFGKT 140 Score = 64.3 bits (155), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 37/86 (43%), Positives = 48/86 (55%) Query: 24 ESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASA 83 E +L + + D+ T LH A GH EIVE LL+ G VN D G +PLH+AA Sbjct: 56 EVLLKNGADVNANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMW 115 Query: 84 GRDEIVKALLGKGAQVNAVNQNGCTP 109 G +EIV+ LL GA A ++ G TP Sbjct: 116 GHEEIVEVLLKNGADARAQDKFGKTP 141 Score = 39.7 bits (91), Expect = 0.001, Method: Compositional matrix adjust. Identities = 30/88 (34%), Positives = 43/88 (48%), Gaps = 9/88 (10%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73 AY+G LE + E +L + + TD LH A GH EIVE LL+ G +D G Sbjct: 80 AYTGHLE-IVEVLLKNGAGVNATDVIGTAPLHLAAMWGHEEIVEVLLKNGADARAQDKFG 138 Query: 74 WSPLHIAASAG--------RDEIVKALL 93 +P +A G R EI++A++ Sbjct: 139 KTPEDLARDNGYESVARLARKEIIRAVV 166 >5MIO-C nrPDB Length = 573 Score = 88.2 bits (217), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 57/145 (39%), Positives = 80/145 (55%) Query: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNG 106 A AG + V L+ G VN D +G +PLH+AA+ G EIV+ LL GA V+A + G Sbjct: 417 AARAGQDDEVRVLMANGADVNATDASGLTPLHLAATYGHLEIVEVLLKHGADVSASDLMG 476 Query: 107 CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTN 166 TPLH AA EI +LL+ GA+ +A D + T + AA G+LK++ LL + A N Sbjct: 477 STPLHLAALIGHLEIVEVLLKHGADVNAVDTWGDTPLRLAAVMGHLKIVEALLKHGADVN 536 Query: 167 IQDTEGNTPLHLACDEERVEEAKLL 191 QD G T + D + A++L Sbjct: 537 AQDKFGKTAYDTSIDNGSEDLAEIL 561 Score = 86.7 bits (213), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 51/128 (39%), Positives = 77/128 (60%) Query: 80 AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139 AA AG+D+ V+ L+ GA VNA + +G TPLH AA+ EI +LL+ GA+ A D Sbjct: 417 AARAGQDDEVRVLMANGADVNATDASGLTPLHLAATYGHLEIVEVLLKHGADVSASDLMG 476 Query: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199 +T +H AA G+L+++ +LL + A N DT G+TPL LA ++ + L+ GA + Sbjct: 477 STPLHLAALIGHLEIVEVLLKHGADVNAVDTWGDTPLRLAAVMGHLKIVEALLKHGADVN 536 Query: 200 IENKEEKT 207 ++K KT Sbjct: 537 AQDKFGKT 544 Score = 85.1 bits (209), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 57/145 (39%), Positives = 82/145 (56%), Gaps = 1/145 (0%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73 A +G+ +E++ ++A+ + TD T LH A + GH EIVE LL+ G V+ D G Sbjct: 418 ARAGQDDEVR-VLMANGADVNATDASGLTPLHLAATYGHLEIVEVLLKHGADVSASDLMG 476 Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133 +PLH+AA G EIV+ LL GA VNAV+ G TPL AA +I LL+ GA+ + Sbjct: 477 STPLHLAALIGHLEIVEVLLKHGADVNAVDTWGDTPLRLAAVMGHLKIVEALLKHGADVN 536 Query: 134 AKDHYEATAMHRAAAKGNLKMIHIL 158 A+D + TA + G+ + IL Sbjct: 537 AQDKFGKTAYDTSIDNGSEDLAEIL 561 >5HKP-A nrPDB Length = 351 Score = 87.4 bits (215), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 69/201 (34%), Positives = 97/201 (48%), Gaps = 24/201 (11%) Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95 +D T LH A IV+ LLQ G V+ KD G PLH A S G E+ + LL Sbjct: 54 SDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKH 113 Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP--------DAKD----------- 136 GA VNA++ TPLH AASKNR E+ +LL GA+P A D Sbjct: 114 GACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERL 173 Query: 137 --HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC---DEERVEEAKLL 191 ++ ++ +AA + +L + L + Q T LH A +R + A+LL Sbjct: 174 TYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVAELL 233 Query: 192 VSQGASIYIENKEEKTPLQVA 212 + +GA++ +NK+ TPL VA Sbjct: 234 LRKGANVNEKNKDFMTPLHVA 254 Score = 71.6 bits (174), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 53/163 (32%), Positives = 85/163 (52%), Gaps = 2/163 (1%) Query: 27 LADKSL-ATRTDQDSRTALHWACSAGHTE-IVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84 LAD S A T + + L A +G+ E ++ L L V + D +PLH+AA Sbjct: 10 LADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYN 69 Query: 85 RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144 R IV+ LL GA V+A ++ G PLH A S +E+ +LL+ GA +A D ++ T +H Sbjct: 70 RVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLH 129 Query: 145 RAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEE 187 AA+K +++ +LL + A + + G + + +A E E Sbjct: 130 EAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRER 172 Score = 67.4 bits (163), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 48/134 (35%), Positives = 69/134 (51%), Gaps = 1/134 (0%) Query: 80 AASAGRDEIVKALLGK-GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHY 138 AA +G +E + ALL +A + TPLH AA NR I +LL+ GA+ AKD Sbjct: 31 AARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKG 90 Query: 139 EATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASI 198 +H A + G+ ++ +LL + A N D TPLH A + RVE LL+S GA Sbjct: 91 GLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADP 150 Query: 199 YIENKEEKTPLQVA 212 + N K+ + +A Sbjct: 151 TLVNCHGKSAVDMA 164 Score = 60.1 bits (144), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 34/90 (37%), Positives = 53/90 (58%) Query: 85 RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144 R ++ + LL KGA VN N++ TPLH AA + +++ +L + GA +A D TA+H Sbjct: 226 RKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDSLGQTALH 285 Query: 145 RAAAKGNLKMIHILLYYKASTNIQDTEGNT 174 RAA G+L+ +LL Y + +I +G T Sbjct: 286 RAALAGHLQTCRLLLSYGSDPSIISLQGFT 315 Score = 58.9 bits (141), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 34/101 (33%), Positives = 57/101 (56%), Gaps = 3/101 (2%) Query: 35 RTDQDSRTALHWACSAGHT---EIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA 91 + Q TALH A ++ H ++ E LL+ G VN+K+ +PLH+AA +++++ Sbjct: 206 KQPQSHETALHCAVASLHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEV 265 Query: 92 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP 132 L GA++NA++ G T LH AA + +LL G++P Sbjct: 266 LHKHGAKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDP 306 Score = 53.5 bits (127), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 63/241 (26%), Positives = 95/241 (39%), Gaps = 57/241 (23%) Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAA------------SAG 84 D+ LH ACS GH E+ E LL+ G VN D ++PLH AA S G Sbjct: 88 DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHG 147 Query: 85 RDEIVKALLGKGA--------------------------------------QVNAVN--- 103 D + GK A + +N Sbjct: 148 ADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQ 207 Query: 104 -QNGCTPLHYAASK---NRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILL 159 Q+ T LH A + R ++A +LL GAN + K+ T +H AA + + ++ +L Sbjct: 208 PQSHETALHCAVASLHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLH 267 Query: 160 YYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLI 219 + A N D+ G T LH A ++ +LL+S G+ I + + T Q+ + I Sbjct: 268 KHGAKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQI 327 Query: 220 L 220 L Sbjct: 328 L 328 Score = 47.8 bits (112), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 31/103 (30%), Positives = 50/103 (48%) Query: 110 LHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQD 169 L A S N ++ +L N A D ++T +H AA ++++ +LL + A + +D Sbjct: 29 LEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKD 88 Query: 170 TEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212 G PLH AC E +LL+ GA + + + TPL A Sbjct: 89 KGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEA 131 Score = 42.0 bits (97), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 26/91 (28%), Positives = 45/91 (49%) Query: 18 KLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPL 77 K +++ E +L + ++D T LH A H +++E L + G +N D G + L Sbjct: 225 KRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDSLGQTAL 284 Query: 78 HIAASAGRDEIVKALLGKGAQVNAVNQNGCT 108 H AA AG + + LL G+ + ++ G T Sbjct: 285 HRAALAGHLQTCRLLLSYGSDPSIISLQGFT 315 >6AUN-A nrPDB Length = 752 Score = 84.3 bits (207), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 68/246 (27%), Positives = 107/246 (43%), Gaps = 41/246 (16%) Query: 2 EGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFL-L 60 EGC + C S L EL + A + TD TA H+A ++++++ L Sbjct: 151 EGCTPLHLACRKGDSEILVELVQYCHAQMDV---TDNKGETAFHYAVQGDNSQVLQLLGK 207 Query: 61 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAV-------------NQNGC 107 +N + G +PLH+A G+ E+V+ LL A+ N + +Q GC Sbjct: 208 NASAGLNQVNKQGLTPLHLACQMGKQEMVRVLLLCNARCNVMGPSGFPIHTAMKFSQKGC 267 Query: 108 ---------------------TPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146 +PLH+A + E+A MLL+ G + D+ TA+H A Sbjct: 268 AEMIISMDSSQIHSKDPRYGASPLHWAKNA---EMARMLLKRGCDVDSTSAAGNTALHVA 324 Query: 147 AAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEK 206 + + +LL Y A+ GNTPLHLA ++ +E K L+ GA + N + Sbjct: 325 VMRNRFDCVMVLLTYGANAGTPGEHGNTPLHLAISKDNMEMIKALIVFGAEVDTPNDFGE 384 Query: 207 TPLQVA 212 TP +A Sbjct: 385 TPAFMA 390 Score = 55.1 bits (131), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 36/106 (33%), Positives = 52/106 (49%), Gaps = 3/106 (2%) Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101 + LHWA +A E+ LL+ G V+ AG + LH+A R + V LL GA Sbjct: 289 SPLHWAKNA---EMARMLLKRGCDVDSTSAAGNTALHVAVMRNRFDCVMVLLTYGANAGT 345 Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147 ++G TPLH A SK+ E+ L+ GA D + + T A+ Sbjct: 346 PGEHGNTPLHLAISKDNMEMIKALIVFGAEVDTPNDFGETPAFMAS 391 Score = 53.5 bits (127), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 43/143 (30%), Positives = 64/143 (44%), Gaps = 7/143 (4%) Query: 52 HTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLH 111 H E+++ L L + W+ H+A G E + N+ GCTPLH Sbjct: 103 HVEVLQHLSDL-----IRSHPSWTVTHLAVELGIRECFHHSRIISCANSTENEEGCTPLH 157 Query: 112 YAASKNRHEIAVMLLE-GGANPDAKDHYEATAMHRAAAKGNLKMIHIL-LYYKASTNIQD 169 A K EI V L++ A D D+ TA H A N +++ +L A N + Sbjct: 158 LACRKGDSEILVELVQYCHAQMDVTDNKGETAFHYAVQGDNSQVLQLLGKNASAGLNQVN 217 Query: 170 TEGNTPLHLACDEERVEEAKLLV 192 +G TPLHLAC + E ++L+ Sbjct: 218 KQGLTPLHLACQMGKQEMVRVLL 240 Score = 49.7 bits (117), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 54/215 (25%), Positives = 94/215 (43%), Gaps = 10/215 (4%) Query: 15 YSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGW 74 Y ++ L +L S R+ S T H A G E + + +++ G Sbjct: 95 YESSVQVLHVEVLQHLSDLIRS-HPSWTVTHLAVELGIRECFHHSRIISCANSTENEEGC 153 Query: 75 SPLHIAASAGRDEIVKALLGK-GAQVNAVNQNGCTPLHYAASKNRHEIAVML-LEGGANP 132 +PLH+A G EI+ L+ AQ++ + G T HYA + ++ +L A Sbjct: 154 TPLHLACRKGDSEILVELVQYCHAQMDVTDNKGETAFHYAVQGDNSQVLQLLGKNASAGL 213 Query: 133 DAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLV 192 + + T +H A G +M+ +LL A N+ G P+H A + A++++ Sbjct: 214 NQVNKQGLTPLHLACQMGKQEMVRVLLLCNARCNVMGPSG-FPIHTAMKFSQKGCAEMII 272 Query: 193 SQGASIYIENKEEK---TPLQVAKGG--LGLILKR 222 S +S I +K+ + +PL AK ++LKR Sbjct: 273 SMDSS-QIHSKDPRYGASPLHWAKNAEMARMLLKR 306 Score = 43.9 bits (102), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 29/91 (31%), Positives = 43/91 (47%) Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101 TALH A + V LL G + G +PLH+A S E++KAL+ GA+V+ Sbjct: 319 TALHVAVMRNRFDCVMVLLTYGANAGTPGEHGNTPLHLAISKDNMEMIKALIVFGAEVDT 378 Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANP 132 N G TP A+ ++ +M + P Sbjct: 379 PNDFGETPAFMASKISKQLQDLMPISRARKP 409 >4OT9-A nrPDB Length = 359 Score = 80.1 bits (196), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 65/192 (33%), Positives = 94/192 (48%), Gaps = 13/192 (6%) Query: 29 DKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA--ASAGRD 86 D + T+ +T LH A G T +V FLL++G D G S +H+A A AG Sbjct: 110 DLGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAP 169 Query: 87 EIVKALLGKGAQVNAVNQ-------NGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139 E+++ALL GA AV Q G P+H A E +L++ GA +A + Sbjct: 170 ELLRALLQSGAP--AVPQLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQG 227 Query: 140 A-TAMHRAAAKGNLKMI-HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGAS 197 TA+H A L ++ H++ +A+ N + GNTPLHLA +LL+ GA Sbjct: 228 GRTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGAD 287 Query: 198 IYIENKEEKTPL 209 I+ EN+E PL Sbjct: 288 IHAENEEPLCPL 299 >4Z68-A nrPDB Length = 155 Score = 79.7 bits (195), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 52/137 (37%), Positives = 77/137 (56%), Gaps = 3/137 (2%) Query: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGW--SPLHIAASAGRDEIVKALLGKGAQVNAVNQ 104 A AG E V+ L + VN +D G +PLH AA R +V+ LL GA V+A ++ Sbjct: 10 AAKAGDVETVKKLCTVQ-SVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDK 68 Query: 105 NGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAS 164 G PLH A S +E+A +L++ GA + D ++ T +H AAAKG ++ +LL + A Sbjct: 69 GGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGAD 128 Query: 165 TNIQDTEGNTPLHLACD 181 ++ +GNTPL L D Sbjct: 129 PTKKNRDGNTPLDLVKD 145 Score = 75.1 bits (183), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 45/123 (36%), Positives = 65/123 (52%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73 A +G +E +K+ + T LH+A +VE+LLQ G V+ KD G Sbjct: 11 AKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGG 70 Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133 PLH A S G E+ + L+ GA VN + TPLH AA+K ++EI +LL+ GA+P Sbjct: 71 LVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPT 130 Query: 134 AKD 136 K+ Sbjct: 131 KKN 133 Score = 70.9 bits (172), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 47/137 (34%), Positives = 69/137 (50%), Gaps = 1/137 (0%) Query: 80 AASAGRDEIVKALLG-KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHY 138 AA AG E VK L + + TPLH+AA NR + LL+ GA+ AKD Sbjct: 10 AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKG 69 Query: 139 EATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASI 198 +H A + G+ ++ +L+ + A N+ D TPLH A + + E KLL+ GA Sbjct: 70 GLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADP 129 Query: 199 YIENKEEKTPLQVAKGG 215 +N++ TPL + K G Sbjct: 130 TKKNRDGNTPLDLVKDG 146 Score = 59.3 bits (142), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 33/74 (44%), Positives = 43/74 (58%) Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96 D+ LH ACS GH E+ E L++ G VN D ++PLH AA+ G+ EI K LL G Sbjct: 67 DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG 126 Query: 97 AQVNAVNQNGCTPL 110 A N++G TPL Sbjct: 127 ADPTKKNRDGNTPL 140 Score = 28.5 bits (62), Expect = 2.3, Method: Compositional matrix adjust. Identities = 19/66 (28%), Positives = 29/66 (43%) Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80 E+ E ++ ++ D T LH A + G EI + LLQ G K+ G +PL + Sbjct: 84 EVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV 143 Query: 81 ASAGRD 86 D Sbjct: 144 KDGDTD 149 >5CBO-A nrPDB Length = 176 Score = 78.2 bits (191), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 48/123 (39%), Positives = 69/123 (56%), Gaps = 3/123 (2%) Query: 80 AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139 AA AG+D+ V+ L+ GA VNA++ G TPLH AA EI +LL+ GA+ +A D Sbjct: 10 AAHAGQDDEVRILMANGADVNAMDNFGVTPLHLAAYWGHFEIVEVLLKYGADVNASDATG 69 Query: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLV---SQGA 196 T +H AA G L ++ +LL Y A N QD G T ++ D + A++L +Q A Sbjct: 70 DTPLHLAAKWGYLGIVEVLLKYGADVNAQDKFGKTAFDISIDNGNEDLAEILCKNKAQQA 129 Query: 197 SIY 199 + Y Sbjct: 130 AFY 132 Score = 72.8 bits (177), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 48/117 (41%), Positives = 63/117 (53%) Query: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNG 106 A AG + V L+ G VN D+ G +PLH+AA G EIV+ LL GA VNA + G Sbjct: 10 AAHAGQDDEVRILMANGADVNAMDNFGVTPLHLAAYWGHFEIVEVLLKYGADVNASDATG 69 Query: 107 CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163 TPLH AA I +LL+ GA+ +A+D + TA + GN + IL KA Sbjct: 70 DTPLHLAAKWGYLGIVEVLLKYGADVNAQDKFGKTAFDISIDNGNEDLAEILCKNKA 126 Score = 62.8 bits (151), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 41/112 (36%), Positives = 61/112 (54%), Gaps = 1/112 (0%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73 A++G+ +E++ ++A+ + D T LH A GH EIVE LL+ G VN D G Sbjct: 11 AHAGQDDEVR-ILMANGADVNAMDNFGVTPLHLAAYWGHFEIVEVLLKYGADVNASDATG 69 Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125 +PLH+AA G IV+ LL GA VNA ++ G T + ++A +L Sbjct: 70 DTPLHLAAKWGYLGIVEVLLKYGADVNAQDKFGKTAFDISIDNGNEDLAEIL 121 Score = 57.8 bits (138), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 29/89 (32%), Positives = 51/89 (57%) Query: 124 MLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEE 183 +L+ GA+ +A D++ T +H AA G+ +++ +LL Y A N D G+TPLHLA Sbjct: 21 ILMANGADVNAMDNFGVTPLHLAAYWGHFEIVEVLLKYGADVNASDATGDTPLHLAAKWG 80 Query: 184 RVEEAKLLVSQGASIYIENKEEKTPLQVA 212 + ++L+ GA + ++K KT ++ Sbjct: 81 YLGIVEVLLKYGADVNAQDKFGKTAFDIS 109 >3EU9-A nrPDB Length = 240 Score = 77.0 bits (188), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 52/147 (35%), Positives = 78/147 (53%), Gaps = 4/147 (2%) Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101 T LHWA GH +V L++ G + D G S +H+AA G IV L+ KG V+ Sbjct: 78 TPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDM 137 Query: 102 VNQNGCTPLHYAASKNRHEI--AVMLLEGGANPDAKDHY-EATAMHRAAAKGNLKMIHIL 158 ++QNG TPL +AA + H + +LL + + D Y + TA+H A GN +I +L Sbjct: 138 MDQNGMTPLMWAAYRT-HSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLL 196 Query: 159 LYYKASTNIQDTEGNTPLHLACDEERV 185 L A+ + Q+ +G + L LA + V Sbjct: 197 LEAGANVDAQNIKGESALDLAKQRKNV 223 Score = 65.5 bits (158), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 50/180 (27%), Positives = 84/180 (46%), Gaps = 3/180 (1%) Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVND-KDDAGWSPLHIAASAGRDEIVKALLGK 95 D+++ T LHWA ++V++ + G V+ D +PLH A G +V L+ Sbjct: 39 DKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKY 98 Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKG-NLKM 154 GA + ++ GC+ +H AA I L+ G + D D T + AA + ++ Sbjct: 99 GADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDP 158 Query: 155 IHILLYYKASTNIQDT-EGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213 +LL + S N+ D NT LH A LL+ GA++ +N + ++ L +AK Sbjct: 159 TRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAK 218 Score = 60.8 bits (146), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 46/162 (28%), Positives = 76/162 (46%), Gaps = 2/162 (1%) Query: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN- 105 A G E L++ G V D + LH AA R ++VK + KGA V+ + + Sbjct: 16 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 75 Query: 106 GCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAST 165 TPLH+A + + V L++ GA+P D + +H AA G+ ++ L+ Sbjct: 76 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 135 Query: 166 NIQDTEGNTPLHLAC-DEERVEEAKLLVSQGASIYIENKEEK 206 ++ D G TPL A V+ +LL++ S+ + +K K Sbjct: 136 DMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHK 177 Score = 50.4 bits (119), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 37/134 (27%), Positives = 62/134 (46%), Gaps = 1/134 (0%) Query: 80 AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA-KDHY 138 A G E + L+ G V ++ T LH+AA NR ++ + GA D Sbjct: 16 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 75 Query: 139 EATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASI 198 +T +H A +G+L M+ L+ Y A ++ D EG + +HLA L+++G + Sbjct: 76 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 135 Query: 199 YIENKEEKTPLQVA 212 + ++ TPL A Sbjct: 136 DMMDQNGMTPLMWA 149 >5ET1-A nrPDB Length = 353 Score = 75.1 bits (183), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 60/182 (32%), Positives = 93/182 (51%), Gaps = 7/182 (3%) Query: 38 QDSRTAL--HWACSAGHTEIVEFLLQ-LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLG 94 +DS AL H A +G + +L++ + +P + G +P H AA+ G ++ LL Sbjct: 33 RDSLDALPVHHAARSGKLHCLRYLVEEVALPAVSRARNGATPAHDAAATGYLSCLQWLLT 92 Query: 95 KGA-QVNAVNQNGCTPLHYAASKNRHEIAVMLL-EGGANPDAKDHYEATAMHRAAAKGNL 152 +G +V + +G T LH AA ++ LL +GGAN A +H AAAKG+L Sbjct: 93 QGGCRVQEKDNSGATVLHLAARFGHPDVVKWLLYQGGANSAITTDTGALPIHYAAAKGDL 152 Query: 153 KMIHILL-YYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQ-GASIYIENKEEKTPLQ 210 + +L+ +Y N Q G TPL+LAC E +E K LV + A ++ ++ TPL Sbjct: 153 PSLKLLVGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQECSADPHLRAQDGMTPLH 212 Query: 211 VA 212 A Sbjct: 213 AA 214 Score = 72.8 bits (177), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 64/214 (29%), Positives = 96/214 (44%), Gaps = 38/214 (17%) Query: 37 DQDSRTALHWACSAGHTEIVEFLL-QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95 D T LH A GH ++V++LL Q G D G P+H AA+ G +K L+G Sbjct: 102 DNSGATVLHLAARFGHPDVVKWLLYQGGANSAITTDTGALPIHYAAAKGDLPSLKLLVGH 161 Query: 96 GAQ-VNAVNQNGCTPLHYAASKNRHEIAVMLLEG----------------------GANP 132 + VNA NG TPL+ A + E+ L++ G NP Sbjct: 162 YPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQECSADPHLRAQDGMTPLHAAAQMGHNP 221 Query: 133 -------------DAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179 +DH ATAMH AA++G+ K++ LL + A + QD G TPLH A Sbjct: 222 VLVWLVSFADVSFSEQDHDGATAMHFAASRGHTKVLSWLLLHGAEIS-QDLWGGTPLHDA 280 Query: 180 CDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213 + +E ++L GA + + + + T +A+ Sbjct: 281 AENGELECCQILAVNGAGLDVRDHDGYTAADLAE 314 Score = 54.7 bits (130), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 2/115 (1%) Query: 38 QDSRTALHWACSAGHTEIVEFLLQLG-VPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96 QD T LH A GH ++ +L+ V +++D G + +H AAS G +++ LL G Sbjct: 205 QDGMTPLHAAAQMGHNPVLVWLVSFADVSFSEQDHDGATAMHFAASRGHTKVLSWLLLHG 264 Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN 151 A+++ + G TPLH AA E +L GA D +DH TA A G+ Sbjct: 265 AEISQ-DLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLAEFNGH 318 Score = 47.0 bits (110), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 30/82 (36%), Positives = 47/82 (57%), Gaps = 2/82 (2%) Query: 27 LADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRD 86 AD S + + D D TA+H+A S GHT+++ +LL G ++ +D G +PLH AA G Sbjct: 229 FADVSFSEQ-DHDGATAMHFAASRGHTKVLSWLLLHGAEIS-QDLWGGTPLHDAAENGEL 286 Query: 87 EIVKALLGKGAQVNAVNQNGCT 108 E + L GA ++ + +G T Sbjct: 287 ECCQILAVNGAGLDVRDHDGYT 308 >5GP7-A nrPDB Length = 169 Score = 73.6 bits (179), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 44/116 (37%), Positives = 66/116 (56%), Gaps = 2/116 (1%) Query: 66 VNDKDDAGW--SPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAV 123 +N +D G +PLH+AA E+ + LL GA VNA ++ G PLH AAS +IA Sbjct: 34 INCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAA 93 Query: 124 MLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179 +L++ +A D + T +H AA KG ++ +LL + A +++ EG TPL LA Sbjct: 94 LLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 149 Score = 70.9 bits (172), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 40/105 (38%), Positives = 60/105 (57%) Query: 108 TPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNI 167 TPLH AA N E+A LLE GA+ +A+D +H AA+ G++ + +L+ Y N Sbjct: 45 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA 104 Query: 168 QDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212 D TPLH A + R + LL++ GA ++N+E +TPL +A Sbjct: 105 TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 149 Score = 70.1 bits (170), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 42/109 (38%), Positives = 58/109 (53%) Query: 40 SRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQV 99 + T LH A + E+ E+LL+ G VN +D G PLH AAS G +I L+ V Sbjct: 43 NSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCV 102 Query: 100 NAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148 NA ++ TPLH AA K R ++ +LL GA+P K+ T + A A Sbjct: 103 NATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 151 Score = 54.7 bits (130), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 33/97 (34%), Positives = 46/97 (47%) Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80 E+ E +L + D+ LH A S GH +I L++ VN D ++PLH A Sbjct: 57 EVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEA 116 Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKN 117 A GR ++ LL GA NQ G TPL A + + Sbjct: 117 AQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADD 153 Score = 40.8 bits (94), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 26/73 (35%), Positives = 35/73 (47%) Query: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199 +T +H AA NL++ LL + A N QD G PLH A V+ A LL+ + Sbjct: 44 STPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVN 103 Query: 200 IENKEEKTPLQVA 212 +K TPL A Sbjct: 104 ATDKWAFTPLHEA 116 >3ZKJ-A nrPDB Length = 261 Score = 68.6 bits (166), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 52/169 (30%), Positives = 84/169 (49%), Gaps = 2/169 (1%) Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101 + +H A GH + L+ G VN SPLH A G VK LL GAQVN Sbjct: 5 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 64 Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161 V + TPL A + +LL+ GA+ + A+ +H AA +G+++ ++ L+ Y Sbjct: 65 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDL-ASPIHEAARRGHVECVNSLIAY 123 Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQ 210 + + + + TPL+LAC+ ++ K L+ GA + + K + +PL Sbjct: 124 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLH 171 Score = 60.1 bits (144), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 53/173 (30%), Positives = 75/173 (43%), Gaps = 2/173 (1%) Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98 D + LH AC GH V+ LL+ G VN +PL A +G + V LL GA Sbjct: 35 DHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGAS 94 Query: 99 VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158 V + +P+H AA + E L+ G N D K + T ++ A + L Sbjct: 95 VQP-ESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKL 153 Query: 159 LYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV 211 L A N Q ++PLH E A LL+ GA +N E K P+++ Sbjct: 154 LESGADVN-QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVEL 205 Score = 47.4 bits (111), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 33/112 (29%), Positives = 55/112 (49%), Gaps = 1/112 (0%) Query: 25 SILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84 ++L + + + D + +H A GH E V L+ G ++ K +PL++A Sbjct: 86 NLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQ 145 Query: 85 RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136 + VK LL GA VN + +PLH A E+A +L++ GA+ AK+ Sbjct: 146 QRACVKKLLESGADVNQ-GKGQDSPLHAVARTASEELACLLMDFGADTQAKN 196 >4OAU-C nrPDB Length = 699 Score = 67.0 bits (162), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 66/201 (32%), Positives = 99/201 (49%), Gaps = 18/201 (8%) Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101 T LH A +IVE LL+ G + G +P +AA AG +++K L KGA VN Sbjct: 41 TPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNE 100 Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE----------ATAMHRAAAKGN 151 + G T AA + + L + GAN + + + ATA+ AA KG+ Sbjct: 101 CDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGH 160 Query: 152 LKMIHILL-YYKASTNIQDTEG-NTPLH--LACDEERVEE-AKLLVSQGASIYIENKEEK 206 ++++ ILL A N D G N +H L+ D+ VE LL+ GA + + + K Sbjct: 161 VEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGK 220 Query: 207 TPLQVA--KGGLGLILKRMVE 225 TPL +A K LGL+ +R++E Sbjct: 221 TPLILAVEKKHLGLV-QRLLE 240 Score = 64.7 bits (156), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 51/158 (32%), Positives = 79/158 (50%), Gaps = 12/158 (7%) Query: 53 TEIVEFLLQLGVPVN-DKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLH 111 ++V+ LL+ G VN +++ GW+PLH A R++IV+ LL GA +NG TP Sbjct: 18 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 77 Query: 112 YAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNI---- 167 AA ++ + L GA+ + D Y TA AA G +K + L A+ N+ Sbjct: 78 LAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKT 137 Query: 168 -QDTE-----GNTPLHLACDEERVEEAKLLVSQ-GASI 198 +D E G T L A ++ VE K+L+ + GA + Sbjct: 138 KEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADV 175 Score = 60.5 bits (145), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 42/130 (32%), Positives = 66/130 (50%), Gaps = 1/130 (0%) Query: 87 EIVKALLGKGAQVNAVNQNG-CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHR 145 ++V+ LL GA VN + G TPLH A +R +I +LL GA+P + AT Sbjct: 19 DLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFIL 78 Query: 146 AAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEE 205 AA G++K++ + L A N D G T A +V+ K L +GA++ + K + Sbjct: 79 AAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTK 138 Query: 206 KTPLQVAKGG 215 + ++ KGG Sbjct: 139 EDQERLRKGG 148 Score = 52.0 bits (123), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 48/168 (28%), Positives = 79/168 (47%), Gaps = 15/168 (8%) Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN- 100 T A AG ++++ L G VN+ D G++ AA G+ + +K L +GA VN Sbjct: 74 TPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNL 133 Query: 101 ---------AVNQNGCTPLHYAASKNRHEIAVMLL-EGGANPDAKDHYEATAMHRAAAKG 150 + + G T L AA K E+ +LL E GA+ +A D+ A+ A Sbjct: 134 RRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSS 193 Query: 151 NLK----MIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQ 194 + + H+LL + A N++ G TPL LA +++ + + L+ Q Sbjct: 194 DDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQ 241 Score = 44.3 bits (103), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 52/172 (30%), Positives = 81/172 (47%), Gaps = 16/172 (9%) Query: 42 TALHWACSAGHTEIVEFLLQLGVPVN----DKDD------AGWSPLHIAASAGRDEIVKA 91 TA A G + ++FL + G VN K+D G + L AA G E++K Sbjct: 107 TAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKI 166 Query: 92 LLGK-GAQVNAVNQNGCTPLHYAA----SKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146 LL + GA VNA + G L +A + I +LL+ GA+ + + T + A Sbjct: 167 LLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILA 226 Query: 147 AAKGNLKMIHILLYYK-ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGAS 197 K +L ++ LL + N D++G T L LA + + + A+LL +GAS Sbjct: 227 VEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAS 278 Score = 31.6 bits (70), Expect = 0.26, Method: Compositional matrix adjust. Identities = 38/134 (28%), Positives = 52/134 (38%), Gaps = 39/134 (29%) Query: 42 TALHWACSAGHTEIVEFLL-QLGVPVNDKDDAGWSPLHIAASAGRDEIVKA----LLGKG 96 TAL A GH E+++ LL ++G VN D+ G + L A + D V+A LL G Sbjct: 150 TALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHG 209 Query: 97 AQVNAVNQNGCTPLHYAASKNR----------------------------------HEIA 122 A VN + G TPL A K +IA Sbjct: 210 ADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIA 269 Query: 123 VMLLEGGANPDAKD 136 +L + GA+ D D Sbjct: 270 ELLCKRGASTDCGD 283 >1G3N-B nrPDB Length = 168 Score = 65.5 bits (158), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 36/78 (46%), Positives = 43/78 (55%) Query: 120 EIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179 EIA LL GANPD KD +H AA G L + LL ++A NI+D EGN PLHLA Sbjct: 51 EIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLA 110 Query: 180 CDEERVEEAKLLVSQGAS 197 E + + LV AS Sbjct: 111 AKEGHLRVVEFLVKHTAS 128 Score = 32.7 bits (73), Expect = 0.11, Method: Compositional matrix adjust. Identities = 24/90 (26%), Positives = 45/90 (50%), Gaps = 2/90 (2%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ-LGVPVN 67 ++ + A +G L+ L +++L ++ D + LH A GH +VEFL++ V Sbjct: 73 VIHDAARAGFLDTL-QTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVG 131 Query: 68 DKDDAGWSPLHIAASAGRDEIVKALLGKGA 97 ++ G + +A GR+E+V + GA Sbjct: 132 HRNHKGDTACDLARLYGRNEVVSLMQANGA 161 >5D68-A nrPDB Length = 486 Score = 59.7 bits (143), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 40/122 (32%), Positives = 68/122 (55%), Gaps = 7/122 (5%) Query: 76 PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLE-GGANPDA 134 PLH +A G E++ LL + VN ++ + P+HYA + E +LLE G NP+ Sbjct: 41 PLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNL 100 Query: 135 KDHYEATAMHRAAAKGNLKMIHILLYY-KASTNIQDTEGNTPLHLACDEERV----EEAK 189 + ++ +H AA G+ +++ ILL + + +I D +G +PL++ C+E + E AK Sbjct: 101 LNGQLSSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNI-CEENKQNNWEEAAK 159 Query: 190 LL 191 LL Sbjct: 160 LL 161 Score = 50.1 bits (118), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 35/114 (30%), Positives = 54/114 (47%), Gaps = 9/114 (7%) Query: 30 KSLATRTDQDSRT-----ALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84 +S+++ T+ R LH + G +E++ LL VN D W+P+H A G Sbjct: 23 RSMSSVTEDKERQWVDDFPLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYG 82 Query: 85 RDEIVKALLGKG-AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDH 137 + E + LL KG N +N +PLH+AA EI +LL +P+ H Sbjct: 83 KVEATRILLEKGKCNPNLLNGQLSSPLHFAAGGGHAEIVQILLN---HPETDRH 133 Score = 44.7 bits (104), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 39/130 (30%), Positives = 56/130 (43%), Gaps = 10/130 (7%) Query: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLG-VPVNDKDDAGWSPLHI 79 EL +L+++ + D D +H+AC G E LL+ G N + SPLH Sbjct: 52 ELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNLLNGQLSSPLHF 111 Query: 80 AASAGRDEIVKALLGKG-AQVNAVNQNGCTPLHYA---ASKNRHEIAVMLLEGGANPDAK 135 AA G EIV+ LL + +Q G +PL+ N E A +L E P Sbjct: 112 AAGGGHAEIVQILLNHPETDRHITDQQGRSPLNICEENKQNNWEEAAKLLKEAINKP--- 168 Query: 136 DHYEATAMHR 145 YE ++R Sbjct: 169 --YEKVRIYR 176 Score = 41.6 bits (96), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 43/75 (57%), Gaps = 1/75 (1%) Query: 142 AMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQG-ASIYI 200 +HR+A +G+ +++ LL + S N D++ P+H AC +VE ++L+ +G + + Sbjct: 41 PLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNL 100 Query: 201 ENKEEKTPLQVAKGG 215 N + +PL A GG Sbjct: 101 LNGQLSSPLHFAAGG 115 >4O1O-A nrPDB Length = 717 Score = 58.5 bits (140), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 39/130 (30%), Positives = 62/130 (47%), Gaps = 1/130 (0%) Query: 87 EIVKALLGKGAQVNAVNQN-GCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHR 145 E V+ LL +GA N + G +PLH A + ++ +LL+ GA+P + AT Sbjct: 22 EQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCLRKRNGATPFII 81 Query: 146 AAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEE 205 A GN++++ +LL N D G T A RVE + L GA + + K + Sbjct: 82 AGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTK 141 Query: 206 KTPLQVAKGG 215 + ++ KGG Sbjct: 142 QDQERIRKGG 151 Score = 50.4 bits (119), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 63/227 (27%), Positives = 92/227 (40%), Gaps = 49/227 (21%) Query: 47 ACSAGHTEIVEFLLQLGVPVN-DKDDAGWSPLHIAASAGRDEIVKALLGKGA-------- 97 A E V LL+ G N +++ GWSPLH A +++V LL GA Sbjct: 15 AVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCLRKRN 74 Query: 98 -------------------------QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP 132 VN + NG T AA R E L E GA+ Sbjct: 75 GATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADV 134 Query: 133 D----AKDHYE------ATAMHRAAAKGNLKMIHILLY-YKASTNIQDTEGNTPLHLAC- 180 + K E ATA+ AA KG++ ++ ILL+ KA + +D G L A Sbjct: 135 NMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALL 194 Query: 181 --DEERVEE-AKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMV 224 D+ + + +LL+ GA + + + KTPL +A L L +M+ Sbjct: 195 NPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQML 241 Score = 45.4 bits (106), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 58/178 (32%), Positives = 79/178 (44%), Gaps = 18/178 (10%) Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVN----DKDD------AGWSPLHIAASAGRD 86 D + TA A G E + FL + G VN K D G + L AA G Sbjct: 105 DVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMDAAEKGHV 164 Query: 87 EIVKALL-GKGAQVNAVNQNGCTPLHYAA----SKNRHEIAVMLLEGGANPDAKDHYEAT 141 +V LL A+V+A + G L YA I +LL+ GA+ + + T Sbjct: 165 GVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGADVNVRGEGSKT 224 Query: 142 AMHRAAAKGNLKMIHILLYY-KASTNIQDTEGNTPLHLACDEERVEE-AKLLVSQGAS 197 + A + NL ++ +LL + N D EG T L LA E R+EE AKLL +GAS Sbjct: 225 PLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAV-ELRLEEIAKLLCHRGAS 281 >5DND-A nrPDB Length = 588 Score = 57.8 bits (138), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 36/105 (34%), Positives = 59/105 (56%), Gaps = 1/105 (0%) Query: 50 AGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTP 109 AG E ++ L++LG + KD G + LH+AA GRD +V LL +G VNA +++G +P Sbjct: 432 AGELEALQALMELGSDLRLKDSNGQTLLHVAARNGRDGVVTMLLHRGMDVNARDRDGLSP 491 Query: 110 LHYAASKNRHEIAVMLLEGGANPDAKDHYEA-TAMHRAAAKGNLK 153 L A E +L + GA +D +A T + R A++ +++ Sbjct: 492 LLLAVQGRHRECIRLLRKAGACLSPQDLKDAGTELCRLASRADME 536 Score = 43.9 bits (102), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 42/147 (28%), Positives = 71/147 (48%), Gaps = 2/147 (1%) Query: 13 LAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA 72 LA++G+LE L+ + L + D + +T LH A G +V LL G+ VN +D Sbjct: 429 LAHAGELEALQALMELGSDLRLK-DSNGQTLLHVAARNGRDGVVTMLLHRGMDVNARDRD 487 Query: 73 GWSPLHIAASAGRDEIVKALLGKGAQVNAVN-QNGCTPLHYAASKNRHEIAVMLLEGGAN 131 G SPL +A E ++ L GA ++ + ++ T L AS+ E + GA+ Sbjct: 488 GLSPLLLAVQGRHRECIRLLRKAGACLSPQDLKDAGTELCRLASRADMEGLQAWGQAGAD 547 Query: 132 PDAKDHYEATAMHRAAAKGNLKMIHIL 158 + +A+ A A GN +++ +L Sbjct: 548 LQQPGYDGRSALCVAEAAGNQEVLALL 574 Score = 37.0 bits (84), Expect = 0.007, Method: Compositional matrix adjust. Identities = 27/89 (30%), Positives = 43/89 (48%) Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140 A AG E ++AL+ G+ + + NG T LH AA R + MLL G + +A+D Sbjct: 430 AHAGELEALQALMELGSDLRLKDSNGQTLLHVAARNGRDGVVTMLLHRGMDVNARDRDGL 489 Query: 141 TAMHRAAAKGNLKMIHILLYYKASTNIQD 169 + + A + + I +L A + QD Sbjct: 490 SPLLLAVQGRHRECIRLLRKAGACLSPQD 518 Score = 30.0 bits (66), Expect = 0.89, Method: Compositional matrix adjust. Identities = 17/69 (24%), Positives = 34/69 (49%) Query: 147 AAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEK 206 A G L+ + L+ + ++D+ G T LH+A R +L+ +G + +++ Sbjct: 430 AHAGELEALQALMELGSDLRLKDSNGQTLLHVAARNGRDGVVTMLLHRGMDVNARDRDGL 489 Query: 207 TPLQVAKGG 215 +PL +A G Sbjct: 490 SPLLLAVQG 498 >6EMK-G nrPDB Length = 426 Score = 57.4 bits (137), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 40/129 (31%), Positives = 66/129 (51%), Gaps = 5/129 (3%) Query: 88 IVKALLGKGAQV--NAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD--AKDHYEATAM 143 IVK LL + + N ++NG + LHYA+ R+ I V L++ G + K T + Sbjct: 20 IVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHDKHELIKTFKGNTCV 79 Query: 144 HRAAAKGNLKMIHILLY-YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIEN 202 H A KG+ + +H+LL + N + G P+H+AC + + LL+ GA +++ + Sbjct: 80 HLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQCLSLLIGVGADLWVMD 139 Query: 203 KEEKTPLQV 211 TPL V Sbjct: 140 TNGDTPLHV 148 Score = 43.9 bits (102), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 34/117 (29%), Positives = 50/117 (42%), Gaps = 10/117 (8%) Query: 42 TALHWACSAGHTEIVEFLLQ-LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN 100 T +H A GH + + LLQ +N + + G +P+HIA + + L+G GA + Sbjct: 77 TCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQCLSLLIGVGADLW 136 Query: 101 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHI 157 ++ NG TPLH MLL G E + KGN K I + Sbjct: 137 VMDTNGDTPLHVCLEYGSISCMKMLLNEG---------EVSLDDNVRDKGNWKPIDV 184 Score = 32.0 bits (71), Expect = 0.25, Method: Compositional matrix adjust. Identities = 16/59 (27%), Positives = 29/59 (49%) Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96 ++ R +H AC + + + L+ +G + D G +PLH+ G +K LL +G Sbjct: 107 ENGRAPIHIACMNDYYQCLSLLIGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEG 165 >3EHQ-A nrPDB Length = 222 Score = 53.9 bits (128), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 35/91 (38%), Positives = 50/91 (54%), Gaps = 2/91 (2%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL-QLGVPVNDKDDA 72 A G L L+E L ++ D+ TAL+WAC GH +IVE L Q + +N ++ Sbjct: 81 AKRGNLSWLRE-CLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNKL 139 Query: 73 GWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103 G + LH AA G +IV+ LL KGA+ + N Sbjct: 140 GDTALHAAAWKGYADIVQLLLAKGARTDLRN 170 Score = 34.3 bits (77), Expect = 0.044, Method: Compositional matrix adjust. Identities = 32/138 (23%), Positives = 56/138 (40%), Gaps = 32/138 (23%) Query: 75 SPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134 +PLH AA G ++ L VN +++ G T L++A +I ML Sbjct: 75 NPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLF-------- 126 Query: 135 KDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQ 194 + N+++ N Q+ G+T LH A + + +LL+++ Sbjct: 127 -------------TQPNIEL-----------NQQNKLGDTALHAAAWKGYADIVQLLLAK 162 Query: 195 GASIYIENKEEKTPLQVA 212 GA + N E+K +A Sbjct: 163 GARTDLRNIEKKLAFDMA 180 >2KXP-C nrPDB Length = 118 Score = 51.6 bits (122), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 35/95 (36%), Positives = 46/95 (48%), Gaps = 1/95 (1%) Query: 16 SGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWS 75 +G L+E+K+ + A RT + R LH+A G EI+EFLL G +N D + Sbjct: 12 NGDLDEVKDYV-AKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHIT 70 Query: 76 PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPL 110 PL A G VK LL KGA +G T L Sbjct: 71 PLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAL 105 Score = 50.1 bits (118), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 36/101 (35%), Positives = 50/101 (49%), Gaps = 5/101 (4%) Query: 46 WACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN 105 WA G + V+ + G VN + G PLH AA G+ EI++ LL KGA +NA +++ Sbjct: 8 WALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKH 67 Query: 106 GCTPLHYAASKNRHEIAVMLLEGGAN-----PDAKDHYEAT 141 TPL A + +LL GA+ PD EAT Sbjct: 68 HITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTALEAT 108 Score = 48.5 bits (114), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 30/88 (34%), Positives = 45/88 (51%) Query: 89 VKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148 VK + KG VN + G PLHYAA + EI LL GA+ +A D + T + A Sbjct: 18 VKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVY 77 Query: 149 KGNLKMIHILLYYKASTNIQDTEGNTPL 176 +G++ + +LL A ++ +G T L Sbjct: 78 EGHVSCVKLLLSKGADKTVKGPDGLTAL 105 Score = 37.7 bits (86), Expect = 0.004, Method: Compositional matrix adjust. Identities = 29/85 (34%), Positives = 39/85 (45%), Gaps = 10/85 (11%) Query: 126 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV 185 LEGG P +H AA G L+++ LL A N D TPL A E V Sbjct: 32 LEGGRKP----------LHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHV 81 Query: 186 EEAKLLVSQGASIYIENKEEKTPLQ 210 KLL+S+GA ++ + T L+ Sbjct: 82 SCVKLLLSKGADKTVKGPDGLTALE 106 >5U0J-A nrPDB Length = 140 Score = 48.5 bits (114), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 34/94 (36%), Positives = 48/94 (51%), Gaps = 6/94 (6%) Query: 1 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60 M V NL+ AY+G + L+ L+ + R D DSRTALH A + GH E+V+FLL Sbjct: 21 MVKSVINLLFA--AYTGDVSALRRFALSAMDMEQR-DYDSRTALHVAAAEGHVEVVKFLL 77 Query: 61 QLGVPVNDKDDAGW--SPLHIAASAGRDEIVKAL 92 + VN W +P+ A G ++ K L Sbjct: 78 E-ACKVNPFPKDRWNNTPMDEALHFGHHDVFKIL 110 Score = 31.2 bits (69), Expect = 0.37, Method: Compositional matrix adjust. Identities = 22/67 (32%), Positives = 29/67 (43%), Gaps = 1/67 (1%) Query: 108 TPLHYAASKNRHEIAVMLLEG-GANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTN 166 T LH AA++ E+ LLE NP KD + T M A G+ + IL Y+ Sbjct: 59 TALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYT 118 Query: 167 IQDTEGN 173 Q N Sbjct: 119 PQGDSDN 125 Score = 27.7 bits (60), Expect = 4.6, Method: Compositional matrix adjust. Identities = 15/43 (34%), Positives = 27/43 (62%), Gaps = 1/43 (2%) Query: 135 KDHYEATAMHRAAAKGNLKMIHILLYY-KASTNIQDTEGNTPL 176 +D+ TA+H AAA+G+++++ LL K + +D NTP+ Sbjct: 53 RDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPM 95 >1BD8-A nrPDB Length = 156 Score = 48.1 bits (113), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 34/108 (31%), Positives = 51/108 (47%), Gaps = 1/108 (0%) Query: 51 GHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPL 110 G T I LL+ G N +D +G SP+H AA G + +K L+ GA VN + G P+ Sbjct: 46 GSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPI 105 Query: 111 HYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158 H A + H V L ++ +D T + A +G ++ IL Sbjct: 106 HLAVQEG-HTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDIL 152 Score = 44.3 bits (103), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 29/100 (29%), Positives = 50/100 (50%), Gaps = 1/100 (1%) Query: 113 AASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172 AA + E+ +L +PDA + + TA+ + G+ + LL AS N+QDT G Sbjct: 10 AARGDVQEVRRLLHRELVHPDALNRFGKTAL-QVMMFGSTAIALELLKQGASPNVQDTSG 68 Query: 173 NTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212 +P+H A ++ K+LV GA + + + P+ +A Sbjct: 69 TSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLA 108 >5U0K-A nrPDB Length = 141 Score = 47.8 bits (112), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 36/91 (39%), Positives = 48/91 (52%), Gaps = 6/91 (6%) Query: 4 CVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLG 63 V NL+ AYSG + L+ L+ + + D DSRTALH A + GH E+V+FL++ Sbjct: 25 TVVNLLFA--AYSGDVSALRRFALSAMDMEQK-DYDSRTALHVAAAEGHIEVVKFLIE-A 80 Query: 64 VPVND--KDDAGWSPLHIAASAGRDEIVKAL 92 VN KD G PL A E+VK L Sbjct: 81 CKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 111 Score = 33.5 bits (75), Expect = 0.082, Method: Compositional matrix adjust. Identities = 21/58 (36%), Positives = 33/58 (56%), Gaps = 1/58 (1%) Query: 135 KDHYEATAMHRAAAKGNLKMIHILLYY-KASTNIQDTEGNTPLHLACDEERVEEAKLL 191 KD+ TA+H AAA+G+++++ L+ K + +D GN PL A +E KLL Sbjct: 54 KDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 111 Score = 32.0 bits (71), Expect = 0.21, Method: Compositional matrix adjust. Identities = 23/96 (23%), Positives = 44/96 (45%), Gaps = 1/96 (1%) Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG-GANPDAK 135 L AA +G ++ + + + T LH AA++ E+ L+E NP AK Sbjct: 29 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAK 88 Query: 136 DHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTE 171 D + + A +L+++ +L Y+ S + +T+ Sbjct: 89 DRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQ 124 Score = 29.3 bits (64), Expect = 1.5, Method: Compositional matrix adjust. Identities = 24/72 (33%), Positives = 36/72 (50%), Gaps = 9/72 (12%) Query: 69 KDDAGWSPLHIAASAGRDEIVKALLGKGAQVN--AVNQNGCTPLHYAASKNRHEIAVMLL 126 KD + LH+AA+ G E+VK L+ + +VN A ++ G PL A N E+ +L Sbjct: 54 KDYDSRTALHVAAAEGHIEVVKFLI-EACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL- 111 Query: 127 EGGANPDAKDHY 138 D +D Y Sbjct: 112 -----QDYQDSY 118 >5UQE-A nrPDB Length = 520 Score = 47.4 bits (111), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 33/90 (36%), Positives = 47/90 (52%), Gaps = 6/90 (6%) Query: 5 VSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGV 64 V NL+ AY+G + L+ L+ + R D DSRTALH A + GH E+V+FLL+ Sbjct: 418 VINLLFA--AYTGDVSALRRFALSAMDMEQR-DYDSRTALHVAAAEGHVEVVKFLLE-AC 473 Query: 65 PVNDKDDAGW--SPLHIAASAGRDEIVKAL 92 VN W +P+ A G ++ K L Sbjct: 474 KVNPFPKDRWNNTPMDEALHFGHHDVFKIL 503 Score = 32.0 bits (71), Expect = 0.23, Method: Compositional matrix adjust. Identities = 22/67 (32%), Positives = 29/67 (43%), Gaps = 1/67 (1%) Query: 108 TPLHYAASKNRHEIAVMLLEG-GANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTN 166 T LH AA++ E+ LLE NP KD + T M A G+ + IL Y+ Sbjct: 452 TALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYT 511 Query: 167 IQDTEGN 173 Q N Sbjct: 512 PQGDSDN 518 Score = 28.1 bits (61), Expect = 3.2, Method: Compositional matrix adjust. Identities = 15/45 (33%), Positives = 28/45 (62%), Gaps = 1/45 (2%) Query: 133 DAKDHYEATAMHRAAAKGNLKMIHILL-YYKASTNIQDTEGNTPL 176 + +D+ TA+H AAA+G+++++ LL K + +D NTP+ Sbjct: 444 EQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPM 488 >3LJN-A nrPDB Length = 364 Score = 47.4 bits (111), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 49/187 (26%), Positives = 86/187 (45%), Gaps = 30/187 (16%) Query: 35 RTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLG 94 ++D ++ +H A G T+ V L++ GV ++ G + LH+A G + K L Sbjct: 15 KSDDENMEKIHVAARKGQTDEVRRLIETGVSPTIQNRFGCTALHLACKFGCVDTAKYLAS 74 Query: 95 KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKM 154 G +V+++ +G P+H A N+ ++ V L+EG AK +M Sbjct: 75 VG-EVHSL-WHGQKPIHLAVMANKTDLVVALVEG-------------------AKERGQM 113 Query: 155 IHILL-------YYKASTNIQDTEGNTPLH--LACDEERVEEAKLLVSQGASIYIENKEE 205 LL + ++++ +G T LH + E +E K+LV GAS ++K + Sbjct: 114 PESLLNECDEREVNEIGSHVKHCKGQTALHWCVGLGPEYLEMIKILVQLGASPTAKDKAD 173 Query: 206 KTPLQVA 212 +TPL A Sbjct: 174 ETPLMRA 180 Score = 47.0 bits (110), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 58/245 (23%), Positives = 109/245 (44%), Gaps = 40/245 (16%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73 A G+ +E++ I S T ++ TALH AC G + ++L +G + + Sbjct: 28 ARKGQTDEVRRLIETGVS-PTIQNRFGCTALHLACKFGCVDTAKYLASVG-----EVHSL 81 Query: 74 W---SPLHIAASAGRDEIVKALLGKGA-----------------QVNAVNQN-----GCT 108 W P+H+A A + ++V AL+ +GA +VN + + G T Sbjct: 82 WHGQKPIHLAVMANKTDLVVALV-EGAKERGQMPESLLNECDEREVNEIGSHVKHCKGQT 140 Query: 109 PLHYAASKNRH--EIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAST- 165 LH+ E+ +L++ GA+P AKD + T + RA N + + +++ S Sbjct: 141 ALHWCVGLGPEYLEMIKILVQLGASPTAKDKADETPLMRAMEFRNREALDLMMDTVPSKS 200 Query: 166 ----NIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA-KGGLGLIL 220 + + +GN+ LH A + A V G + +E+ E PL ++ + + L+ Sbjct: 201 SLRLDYANKQGNSHLHWAILINWEDVAMRFVEMGIDVNMEDNEHTVPLYLSVRAAMVLLT 260 Query: 221 KRMVE 225 K +++ Sbjct: 261 KELLQ 265 Score = 30.0 bits (66), Expect = 0.78, Method: Compositional matrix adjust. Identities = 15/59 (25%), Positives = 30/59 (50%) Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95 ++ + LHWA ++ +++G+ VN +D+ PL+++ A + K LL K Sbjct: 208 NKQGNSHLHWAILINWEDVAMRFVEMGIDVNMEDNEHTVPLYLSVRAAMVLLTKELLQK 266 >1BLX-B nrPDB Length = 166 Score = 47.0 bits (110), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 32/100 (32%), Positives = 50/100 (50%), Gaps = 1/100 (1%) Query: 59 LLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNR 118 LL+ G N +D +G SP+H AA G + +K L+ GA VNA++ G P+H A + Sbjct: 60 LLKQGASPNVQDASGTSPVHDAARTGFLDTLKVLVEHGADVNALDSTGSLPIHLAIREG- 118 Query: 119 HEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158 H V L ++ +D T + A +G ++ IL Sbjct: 119 HSSVVSFLAPESDLHHRDASGLTPLELARQRGAQNLMDIL 158 Score = 39.3 bits (90), Expect = 0.001, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 48/100 (48%), Gaps = 1/100 (1%) Query: 113 AASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172 AA + E+ +L +PDA + + TA+ + G+ + LL AS N+QD G Sbjct: 16 AARGDVQEVRRLLHRELVHPDALNRFGKTAL-QVMMFGSPAVALELLKQGASPNVQDASG 74 Query: 173 NTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212 +P+H A ++ K+LV GA + + P+ +A Sbjct: 75 TSPVHDAARTGFLDTLKVLVEHGADVNALDSTGSLPIHLA 114 >5UIL-A nrPDB Length = 405 Score = 46.6 bits (109), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 29/117 (24%), Positives = 53/117 (45%), Gaps = 4/117 (3%) Query: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNG 106 AC ++ + L++ + +K+ GWSP+ +AA G E++K L+ KGA +N N G Sbjct: 285 ACKYSDSKYIAKLIRAKSILFEKNIYGWSPVIVAAYHGNIELIKWLVSKGANINDRNYKG 344 Query: 107 CTPLHYAAS----KNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILL 159 T Y + ML++ G + D+ + T GN ++ ++ Sbjct: 345 TTVAMYFKDYMLKSGDYSGLKMLIDLGLDLTLTDYKDYTVFDYLEKSGNKNLLQYMM 401 >3T9K-A nrPDB Length = 390 Score = 46.2 bits (108), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 32/88 (36%), Positives = 40/88 (45%) Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGA 97 QD+ T L A +A EFLLQ G VN D AG PLH A G + L +GA Sbjct: 233 QDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGA 292 Query: 98 QVNAVNQNGCTPLHYAASKNRHEIAVML 125 + A + G PL A +I +L Sbjct: 293 DLGARDSEGRDPLTIAMETANADIVTLL 320 Score = 42.7 bits (99), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 32/101 (31%), Positives = 45/101 (44%), Gaps = 2/101 (1%) Query: 93 LGKGAQVNAVN--QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKG 150 L GA VN VN Q+ TPL A + N LL+ GAN + D +H A G Sbjct: 220 LAHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILG 279 Query: 151 NLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLL 191 + + + L A +D+EG PL +A + + LL Sbjct: 280 HTGLACLFLKRGADLGARDSEGRDPLTIAMETANADIVTLL 320 Score = 34.3 bits (77), Expect = 0.044, Method: Compositional matrix adjust. Identities = 23/73 (31%), Positives = 34/73 (46%) Query: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199 AT + +A A +L LL A+ N D+ G PLH A A L + +GA + Sbjct: 236 ATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGADLG 295 Query: 200 IENKEEKTPLQVA 212 + E + PL +A Sbjct: 296 ARDSEGRDPLTIA 308 Score = 33.1 bits (74), Expect = 0.10, Method: Compositional matrix adjust. Identities = 21/69 (30%), Positives = 30/69 (43%) Query: 24 ESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASA 83 E +L + + + D R LH A GHT + L+ G + +D G PL IA Sbjct: 252 EFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGADLGARDSEGRDPLTIAMET 311 Query: 84 GRDEIVKAL 92 +IV L Sbjct: 312 ANADIVTLL 320 Score = 32.0 bits (71), Expect = 0.25, Method: Compositional matrix adjust. Identities = 25/88 (28%), Positives = 39/88 (44%) Query: 75 SPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134 +PL A +A + LL GA VN + G PLH+A +A + L+ GA+ A Sbjct: 237 TPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGADLGA 296 Query: 135 KDHYEATAMHRAAAKGNLKMIHILLYYK 162 +D + A N ++ +L K Sbjct: 297 RDSEGRDPLTIAMETANADIVTLLRLAK 324 >6BOA-A nrPDB Length = 742 Score = 43.9 bits (102), Expect = 5e-05, Method: Composition-based stats. Identities = 43/156 (27%), Positives = 66/156 (42%), Gaps = 19/156 (12%) Query: 75 SPLHIAASAGRDEIVKALLG-KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA--- 130 SPL +AA + + LL + +V+ G T LH AA + E A++L+E Sbjct: 47 SPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELV 106 Query: 131 -NPDAKDHYEA-TAMHRAAAKGNLKMIHILLYYKASTNIQDTE-------------GNTP 175 P + YE TA+H A N+ ++ LL +AS + + T G P Sbjct: 107 FEPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHP 166 Query: 176 LHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV 211 L A E +LL+ GA I ++ T L + Sbjct: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 Score = 34.3 bits (77), Expect = 0.041, Method: Composition-based stats. Identities = 40/155 (25%), Positives = 58/155 (37%), Gaps = 51/155 (32%) Query: 42 TALHWACSAGHTEIVEFLLQLGV-----PVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96 TALH A + E L++ P+ + G + LHIA +V+ALL + Sbjct: 81 TALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVVNQNMNLVRALLARR 140 Query: 97 AQVNA------VNQNGCT-------PLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAM 143 A V+A ++ C PL +AA N EI +L+E GA+ A Sbjct: 141 ASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRA--------- 191 Query: 144 HRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHL 178 QD+ GNT LH+ Sbjct: 192 ------------------------QDSLGNTVLHI 202 Score = 31.6 bits (70), Expect = 0.30, Method: Composition-based stats. Identities = 25/86 (29%), Positives = 36/86 (41%), Gaps = 13/86 (15%) Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA-------------GWSPLHIAASAGR 85 + +TALH A + +V LL V+ + G PL AA Sbjct: 116 EGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNS 175 Query: 86 DEIVKALLGKGAQVNAVNQNGCTPLH 111 +EIV+ L+ GA + A + G T LH Sbjct: 176 EEIVRLLIEHGADIRAQDSLGNTVLH 201 >3UI2-A nrPDB Length = 244 Score = 43.9 bits (102), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 32/106 (30%), Positives = 52/106 (49%), Gaps = 2/106 (1%) Query: 75 SPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134 +P AA ++ + LL + V+AV++NG T L + A + +L E GA+ D Sbjct: 47 TPWWTAARKADEQALSQLL-EDRDVDAVDENGRTALLFVAGLGSDKCVRLLAEAGADLDH 105 Query: 135 KDHYEA-TAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179 +D TA+H AA +++ L+ A ++D G T L LA Sbjct: 106 RDMRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELA 151 Score = 42.7 bits (99), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 28/89 (31%), Positives = 47/89 (52%), Gaps = 2/89 (2%) Query: 26 ILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKD-DAGWSPLHIAASAG 84 +L D+ + D++ RTAL + G + V L + G ++ +D G + LH+AA Sbjct: 64 LLEDRDVDA-VDENGRTALLFVAGLGSDKCVRLLAEAGADLDHRDMRGGLTALHMAAGYV 122 Query: 85 RDEIVKALLGKGAQVNAVNQNGCTPLHYA 113 R E+V+AL+ GA + ++ G T L A Sbjct: 123 RPEVVEALVELGADIEVEDERGLTALELA 151 >1DCQ-A nrPDB Length = 278 Score = 43.9 bits (102), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 30/91 (32%), Positives = 46/91 (50%), Gaps = 9/91 (9%) Query: 126 LEGGANPDAKDHYEATAMH---RAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDE 182 L G PD TA+H R+ + +L ++ L+ + + Q +G+T LH C Sbjct: 162 LANGHEPDE------TALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLT 215 Query: 183 ERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213 + E KLL+ ASI I N+ +TPL +AK Sbjct: 216 DNAECLKLLLRGKASIEIANESGETPLDIAK 246 Score = 34.7 bits (78), Expect = 0.030, Method: Compositional matrix adjust. Identities = 39/154 (25%), Positives = 58/154 (37%), Gaps = 27/154 (17%) Query: 29 DKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEI 88 ++ A + D+ LH C A T + LLQ A + G D Sbjct: 116 ERRYARKKHADTAAKLHSLCEAVKTRDIFGLLQ------------------AYADGVDLT 157 Query: 89 VKALLGKGAQVNAVNQNGCTPLHYAA---SKNRHEIAVMLLEGGANPDAKDHYEATAMHR 145 K L G + + T LH A + I L++ N D + +TA+H Sbjct: 158 EKIPLANGHEPDE------TALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHY 211 Query: 146 AAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179 N + + +LL KAS I + G TPL +A Sbjct: 212 CCLTDNAECLKLLLRGKASIEIANESGETPLDIA 245 >3DEO-A nrPDB Length = 183 Score = 43.1 bits (100), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 32/106 (30%), Positives = 52/106 (49%), Gaps = 2/106 (1%) Query: 75 SPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134 +P AA ++ + LL + V+AV++NG T L + A + +L E GA+ D Sbjct: 46 TPWWTAARKADEQALSQLL-EDRDVDAVDENGRTALLFVAGLGSDKCVRLLAEAGADLDH 104 Query: 135 KDHYEA-TAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179 +D TA+H AA +++ L+ A ++D G T L LA Sbjct: 105 RDMRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELA 150 Score = 42.7 bits (99), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 29/95 (30%), Positives = 49/95 (51%), Gaps = 2/95 (2%) Query: 20 EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKD-DAGWSPLH 78 E+ +L D+ + D++ RTAL + G + V L + G ++ +D G + LH Sbjct: 57 EQALSQLLEDRDVDA-VDENGRTALLFVAGLGSDKCVRLLAEAGADLDHRDMRGGLTALH 115 Query: 79 IAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYA 113 +AA R E+V+AL+ GA + ++ G T L A Sbjct: 116 MAAGYVRPEVVEALVELGADIEVEDERGLTALELA 150 >4XD0-A nrPDB Length = 417 Score = 42.7 bits (99), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 22/66 (33%), Positives = 34/66 (51%) Query: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNG 106 AC E + LL+ + +K+ GWSP+ IAA G ++++ L+ KG +N N G Sbjct: 298 ACEDKSPEFISKLLKTENILFEKNHLGWSPIIIAAYHGNMDVIEWLVSKGVNINDRNYKG 357 Query: 107 CTPLHY 112 T Y Sbjct: 358 TTVAMY 363 >6E2G-A nrPDB Length = 727 Score = 40.4 bits (93), Expect = 6e-04, Method: Composition-based stats. Identities = 41/157 (26%), Positives = 62/157 (39%), Gaps = 25/157 (15%) Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA-------------GWSPLHIAASAGR 85 + +TALH A + +V LL G V+ + G PL AA G Sbjct: 116 EGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGS 175 Query: 86 DEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA----- 140 +EIV+ L+ GA + A + G T LH + A + + D DH ++ Sbjct: 176 EEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGGDHLKSLELVP 235 Query: 141 -----TAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172 T A +GN+ M L+ + +IQ T G Sbjct: 236 NNQGLTPFKLAGVEGNIVMFQHLM--QKRKHIQWTYG 270 Score = 39.7 bits (91), Expect = 0.001, Method: Composition-based stats. Identities = 37/142 (26%), Positives = 60/142 (42%), Gaps = 25/142 (17%) Query: 42 TALHWACSAGHTEIVEFLLQLGV-----PVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96 TALH A + E L++ P+ + G + LHIA +V+ALL +G Sbjct: 81 TALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVINQNVNLVRALLARG 140 Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156 A V+A + + HY P +Y + AA G+ +++ Sbjct: 141 ASVSA--RATGSVFHY------------------RPHNLIYYGEHPLSFAACVGSEEIVR 180 Query: 157 ILLYYKASTNIQDTEGNTPLHL 178 +L+ + A QD+ GNT LH+ Sbjct: 181 LLIEHGADIRAQDSLGNTVLHI 202 Score = 36.2 bits (82), Expect = 0.011, Method: Composition-based stats. Identities = 30/98 (30%), Positives = 49/98 (50%), Gaps = 8/98 (8%) Query: 108 TPLHYAASKNRHEIAVMLLE-GGANPDAKDHYEATAMHRAAAKGNLKMIHIL------LY 160 +PL AA +N + + LL+ G K TA+H AA NL+ +L L Sbjct: 47 SPLLLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLMEAAPELV 106 Query: 161 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASI 198 ++ T+ + EG T LH+A + V + L+++GAS+ Sbjct: 107 FEPMTS-ELYEGQTALHIAVINQNVNLVRALLARGASV 143 >6DMR-A nrPDB Length = 730 Score = 38.9 bits (89), Expect = 0.002, Method: Composition-based stats. Identities = 38/143 (26%), Positives = 61/143 (42%), Gaps = 27/143 (18%) Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDA------GWSPLHIAASAGRDEIVKALLGK 95 TALH A + E L++ P K+ A G + LHIA +V+ALL + Sbjct: 81 TALHVAALYDNLEAATLLME-AAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLAR 139 Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155 GA V+A A ++ H + +Y + AA G+ +++ Sbjct: 140 GASVSARATGA------AFRRSPHNLI--------------YYGEHPLSFAACVGSEEIV 179 Query: 156 HILLYYKASTNIQDTEGNTPLHL 178 +L+ + A QD+ GNT LH+ Sbjct: 180 RLLIEHGADIRAQDSLGNTVLHI 202 Score = 36.6 bits (83), Expect = 0.009, Method: Composition-based stats. Identities = 27/84 (32%), Positives = 37/84 (44%), Gaps = 13/84 (15%) Query: 41 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDA-------------GWSPLHIAASAGRDE 87 +TALH A + +V LL G V+ + G PL AA G +E Sbjct: 118 QTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSEE 177 Query: 88 IVKALLGKGAQVNAVNQNGCTPLH 111 IV+ L+ GA + A + G T LH Sbjct: 178 IVRLLIEHGADIRAQDSLGNTVLH 201 Score = 26.9 bits (58), Expect = 7.1, Method: Composition-based stats. Identities = 18/63 (28%), Positives = 31/63 (49%), Gaps = 5/63 (7%) Query: 141 TAMHRAAAKGNLKMIHILL-----YYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQG 195 TA+H AA NL+ +L+ K + G T LH+A + + + L+++G Sbjct: 81 TALHVAALYDNLEAATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARG 140 Query: 196 ASI 198 AS+ Sbjct: 141 ASV 143 >4BSZ-B nrPDB Length = 202 Score = 38.9 bits (89), Expect = 0.002, Method: Compositional matrix adjust. Identities = 37/142 (26%), Positives = 66/142 (46%), Gaps = 28/142 (19%) Query: 14 AYSGKLEELKE---SILADKSLAT-RTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 A +G L+ LK+ ++++ + L+T + + TALH A + GH E V ++L+ N Sbjct: 22 ARAGDLDSLKDIFTTLVSPELLSTCKESESDSTALHMAAANGHIETVRYILETVSRANSA 81 Query: 70 DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLL-EG 128 +D +KA VN VN+ G T LH+A+ + ++ +L E Sbjct: 82 ED-----------------LKAF------VNEVNKTGNTALHWASLNGKLDVVKLLCDEY 118 Query: 129 GANPDAKDHYEATAMHRAAAKG 150 A+P ++ + A+ A G Sbjct: 119 EADPFIRNKFGHDAIFEAENSG 140 Score = 30.8 bits (68), Expect = 0.49, Method: Compositional matrix adjust. Identities = 24/76 (31%), Positives = 38/76 (50%), Gaps = 11/76 (14%) Query: 139 EATAMHRAAAKGNLKMIHILLY----------YKASTNIQDTEGNTPLHLACDEERVEEA 188 ++TA+H AAA G+++ + +L KA N + GNT LH A +++ Sbjct: 52 DSTALHMAAANGHIETVRYILETVSRANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVV 111 Query: 189 KLLVSQ-GASIYIENK 203 KLL + A +I NK Sbjct: 112 KLLCDEYEADPFIRNK 127 >2RFA-A nrPDB Length = 232 Score = 38.5 bits (88), Expect = 0.003, Method: Compositional matrix adjust. Identities = 45/158 (28%), Positives = 67/158 (42%), Gaps = 20/158 (12%) Query: 74 W-SPLHIAASAGRDEIVKALLG-KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA- 130 W SPL +AA + + LL +G +V+ G T LH AA + E A++L+E Sbjct: 3 WESPLLLAAKENDVQALSKLLKFEGCEVHQRGAMGETALHIAALYDNLEAAMVLMEAAPE 62 Query: 131 ---NPDAKDHYEA-TAMHRAAAKGNLKMIHILLYYKASTNIQDT-------------EGN 173 P + YE TA+H A N+ ++ LL AS + + T G Sbjct: 63 LVFEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGE 122 Query: 174 TPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV 211 PL A E +LL+ GA I ++ T L + Sbjct: 123 HPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHI 160 Score = 38.1 bits (87), Expect = 0.003, Method: Compositional matrix adjust. Identities = 37/144 (25%), Positives = 56/144 (38%), Gaps = 23/144 (15%) Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA-------------GWSPLHIAASAGR 85 + +TALH A + +V LL G V+ + G PL AA G Sbjct: 74 EGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGS 133 Query: 86 DEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA----- 140 +EIV+ L+ GA + A + G T LH + A + + D DH ++ Sbjct: 134 EEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGGDHLKSLELVP 193 Query: 141 -----TAMHRAAAKGNLKMIHILL 159 T A +GN+ M L+ Sbjct: 194 NNQGLTPFKLAGVEGNIVMFQHLM 217 Score = 37.7 bits (86), Expect = 0.004, Method: Compositional matrix adjust. Identities = 37/142 (26%), Positives = 61/142 (42%), Gaps = 25/142 (17%) Query: 42 TALHWACSAGHTEIVEFLLQ-----LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96 TALH A + E L++ + P+ + G + LHIA +V+ALL +G Sbjct: 39 TALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVINQNVNLVRALLARG 98 Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156 A V+A + + HY P +Y + AA G+ +++ Sbjct: 99 ASVSA--RATGSVFHY------------------RPHNLIYYGEHPLSFAACVGSEEIVR 138 Query: 157 ILLYYKASTNIQDTEGNTPLHL 178 +L+ + A QD+ GNT LH+ Sbjct: 139 LLIEHGADIRAQDSLGNTVLHI 160 >2A5E-A nrPDB Length = 156 Score = 35.0 bits (79), Expect = 0.026, Method: Compositional matrix adjust. Identities = 29/105 (27%), Positives = 50/105 (47%), Gaps = 2/105 (1%) Query: 110 LHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQD 169 L AA++ R E LLE GA P+A + Y + G+ ++ +LL + A N D Sbjct: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCAD 74 Query: 170 TEGNT-PLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213 T P+H A E ++ +L GA + + + + P+ +A+ Sbjct: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAE 119 >5IRX-A nrPDB Length = 636 Score = 33.5 bits (75), Expect = 0.074, Method: Compositional matrix adjust. Identities = 44/188 (23%), Positives = 76/188 (40%), Gaps = 49/188 (26%) Query: 84 GRDEIVKALLGKGAQVNAVNQ-----------NGCTPLHYAASKNRHEIAVMLLEGGANP 132 G+++ + LL + +++ Q G T LH A + + +L+E GA+ Sbjct: 63 GQNDTIALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENGADV 122 Query: 133 DAK---DHYEAT-----------AMHRAAAKGNLKMIHILL---YYKASTNIQDTEGNTP 175 A D ++ T + AA L ++ LL + A + +D+ GNT Sbjct: 123 QAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTV 182 Query: 176 LHLACD--EERVEEAKLLVSQ-------GASIY-------IENKEEKTPLQVAK-----G 214 LH + + V+ K + S GA ++ I N++ TPL +A G Sbjct: 183 LHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIG 242 Query: 215 GLGLILKR 222 L IL+R Sbjct: 243 VLAYILQR 250 >1D9S-A nrPDB Length = 136 Score = 33.5 bits (75), Expect = 0.078, Method: Compositional matrix adjust. Identities = 27/105 (25%), Positives = 52/105 (49%), Gaps = 2/105 (1%) Query: 110 LHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQD 169 L AA++ + E LLE GA+P+A + + + + G+ ++ +LL + A N D Sbjct: 16 LATAAARGQVETVRQLLEAGADPNALNRFGRRPI-QVMMMGSAQVAELLLLHGAEPNCAD 74 Query: 170 TEGNT-PLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213 T P+H A E ++ +L GA + + + + P+ +A+ Sbjct: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVCDAWGRLPVDLAE 119 Score = 26.9 bits (58), Expect = 7.3, Method: Compositional matrix adjust. Identities = 22/76 (28%), Positives = 35/76 (46%), Gaps = 1/76 (1%) Query: 51 GHTEIVEFLLQLGVPVNDKDDAGWS-PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTP 109 G ++ E LL G N D A + P+H AA G + + L GA+++ + G P Sbjct: 55 GSAQVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVCDAWGRLP 114 Query: 110 LHYAASKNRHEIAVML 125 + A + +IA L Sbjct: 115 VDLAEEQGHRDIARYL 130 >4GMM-A nrPDB Length = 612 Score = 32.7 bits (73), Expect = 0.13, Method: Compositional matrix adjust. Identities = 27/84 (32%), Positives = 37/84 (44%), Gaps = 5/84 (5%) Query: 79 IAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAV---MLLEGGANPDAK 135 IA R EI+ G G N++ C L A+ + E + ML+ G NP+ K Sbjct: 219 IAHLPDRREIIS--FGSGYGGNSLLGKKCFALRIASRLAKEEGWLAEHMLILGITNPEGK 276 Query: 136 DHYEATAMHRAAAKGNLKMIHILL 159 Y A A A K NL M++ L Sbjct: 277 KKYLAAAFPSACGKTNLAMMNPTL 300 >2NYJ-A nrPDB Length = 273 Score = 32.7 bits (73), Expect = 0.13, Method: Compositional matrix adjust. Identities = 40/157 (25%), Positives = 65/157 (41%), Gaps = 38/157 (24%) Query: 106 GCTPLHYAASKNRHEIAVMLLEGGANPDAK---DHYEAT-----------AMHRAAAKGN 151 G T LH A + + +L+E GA+ A D ++ T + AA Sbjct: 101 GQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQ 160 Query: 152 LKMIHILL---YYKASTNIQDTEGNTPLHLACD--EERVEEAKLLVSQ-------GASIY 199 L ++ LL + A + +D+ GNT LH + + V+ K + S GA ++ Sbjct: 161 LAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLH 220 Query: 200 -------IENKEEKTPLQVAK-----GGLGLILKRMV 224 I N++ TPL +A G L IL+R + Sbjct: 221 PTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREI 257 >3I5Q-B nrPDB Length = 252 Score = 32.7 bits (73), Expect = 0.13, Method: Compositional matrix adjust. Identities = 27/111 (24%), Positives = 50/111 (45%), Gaps = 24/111 (21%) Query: 82 SAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDH---- 137 SA +DE++K L GK + + + PL Y HEIA+ + + D +DH Sbjct: 37 SAIKDELIKTLDGKILSTSELFNDFAVPLSY------HEIALFIFKIA---DFRDHEVIM 87 Query: 138 ------YEATAM---HRAAAKGNLKMIHIL--LYYKASTNIQDTEGNTPLH 177 +++ M + + ++ I++L + K N+QD+E P+ Sbjct: 88 AKWDELFQSLRMEFNNTGKKEDSMNFINLLSNVLIKIGKNVQDSEFIFPIF 138 >3I5P-A nrPDB Length = 525 Score = 32.3 bits (72), Expect = 0.15, Method: Compositional matrix adjust. Identities = 27/111 (24%), Positives = 50/111 (45%), Gaps = 24/111 (21%) Query: 82 SAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDH---- 137 SA +DE++K L GK + + + PL Y HEIA+ + + D +DH Sbjct: 310 SAIKDELIKTLDGKILSTSELFNDFAVPLSY------HEIALFIFKIA---DFRDHEVIM 360 Query: 138 ------YEATAM---HRAAAKGNLKMIHIL--LYYKASTNIQDTEGNTPLH 177 +++ M + + ++ I++L + K N+QD+E P+ Sbjct: 361 AKWDELFQSLRMEFNNTGKKEDSMNFINLLSNVLIKIGKNVQDSEFIFPIF 411 >2B0O-E nrPDB Length = 301 Score = 32.3 bits (72), Expect = 0.15, Method: Compositional matrix adjust. Identities = 24/71 (33%), Positives = 37/71 (52%) Query: 55 IVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAA 114 +V+F++Q G ++ K G + LH AA + + +K LL A V VN+ G T L A Sbjct: 208 LVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALDIAR 267 Query: 115 SKNRHEIAVML 125 K+ E +L Sbjct: 268 KKHHKECEELL 278 Score = 28.5 bits (62), Expect = 2.5, Method: Compositional matrix adjust. Identities = 19/57 (33%), Positives = 31/57 (54%), Gaps = 3/57 (5%) Query: 77 LHIA---ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA 130 LH+A A+ +V ++ G ++A +G T LHYAA N+ + +LL+G A Sbjct: 194 LHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRA 250 Score = 26.6 bits (57), Expect = 9.9, Method: Compositional matrix adjust. Identities = 32/123 (26%), Positives = 55/123 (44%), Gaps = 19/123 (15%) Query: 107 CTPLH---YAASKNRHEIAVMLLEGGAN----------PDAKDHYEATAMH---RAAAKG 150 CTP + A NR ++V LE AN PDA+ E +H + A + Sbjct: 148 CTPEPQRLWTAICNRDLLSV--LEAFANGQDFGQPLPGPDAQAP-EELVLHLAVKVANQA 204 Query: 151 NLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQ 210 +L ++ ++ + + +GNT LH A + + KLL+ A + N+ +T L Sbjct: 205 SLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALD 264 Query: 211 VAK 213 +A+ Sbjct: 265 IAR 267 >3LVQ-E nrPDB Length = 497 Score = 32.3 bits (72), Expect = 0.16, Method: Compositional matrix adjust. Identities = 25/76 (32%), Positives = 39/76 (51%) Query: 55 IVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAA 114 +V+F++Q G ++ K G + LH AA + + +K LL A V VN+ G T L A Sbjct: 189 LVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALDIAR 248 Query: 115 SKNRHEIAVMLLEGGA 130 K+ E +L + A Sbjct: 249 KKHHKECEELLEQAQA 264 >6DVZ-A nrPDB Length = 791 Score = 32.0 bits (71), Expect = 0.21, Method: Composition-based stats. Identities = 34/149 (22%), Positives = 62/149 (41%), Gaps = 27/149 (18%) Query: 73 GWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN--------------GCTPLHYAASKNR 118 G + L+IA + +I L+ GA VNA + G TPL AA N+ Sbjct: 215 GQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAACTNQ 274 Query: 119 HEIAVMLLEG-GANPDAKDHYEATAMHRAAAKGN--------LKMIHILLYYKAST---- 165 EI +L+E + ++D +H +K ++ ++ ++ Sbjct: 275 PEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELE 334 Query: 166 NIQDTEGNTPLHLACDEERVEEAKLLVSQ 194 +++ +G TPL LA + E K ++S+ Sbjct: 335 TMRNNDGLTPLQLAAKMGKAEILKYILSR 363 >6OO7-A nrPDB Length = 786 Score = 31.2 bits (69), Expect = 0.43, Method: Composition-based stats. Identities = 43/162 (26%), Positives = 66/162 (40%), Gaps = 33/162 (20%) Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD-------------HYEATAM 143 AQ G + LH A K + +L+E GAN AK ++ + Sbjct: 153 AQCTDEYYRGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPL 212 Query: 144 HRAAAKGNLKMIHILL---YYKASTNIQDTEGNTPLH--LACDEERVEEAKL-------L 191 AA +++ LL + AS QD+ GNT LH + ++ E + L L Sbjct: 213 SLAACTKQWDVVNYLLENPHQPASLQAQDSLGNTVLHALVMIADDSAENSALVVRMYDGL 272 Query: 192 VSQGASIY-------IENKEEKTPLQV-AKGGLGLILKRMVE 225 + GA + I N E TPL++ AK G I K +++ Sbjct: 273 LQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQ 314 >6G1K-A nrPDB Length = 921 Score = 30.0 bits (66), Expect = 0.84, Method: Compositional matrix adjust. Identities = 32/104 (30%), Positives = 46/104 (44%), Gaps = 12/104 (11%) Query: 37 DQDSRTALHWACSAGHTEIVEFLLQLGVPVND-------KDDAGWSPLHI--AASAGRDE 87 D RTAL A + EI+E LL V V D K+ G L + +G + Sbjct: 67 DPLGRTALLIAIENENLEIIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQ 126 Query: 88 IVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131 + LL K Q + + TP+ AA N +EI ML++ G + Sbjct: 127 VPPILLDK--QFSDFTPD-ITPIILAAHTNNYEIIKMLVQKGVS 167 >4N5Q-A nrPDB Length = 257 Score = 29.6 bits (65), Expect = 1.1, Method: Compositional matrix adjust. Identities = 38/149 (25%), Positives = 63/149 (42%), Gaps = 27/149 (18%) Query: 73 GWSPLHIAASAGRDEIVKALLGKGAQVNA----VNQN----------GCTPLHYAASKNR 118 G + L+IA + +I L+ GA VNA V N G TPL AA N+ Sbjct: 99 GQTALNIAIERRQGDITAVLIAAGADVNAHAKGVFFNPKYQHEGFYFGETPLALAACTNQ 158 Query: 119 HEIAVMLLEGG----ANPDAKD----HYEATAMHRAAAKGNL--KMIHILLYYKAS---T 165 EI +L+E + D++ H T + + +M ++L + Sbjct: 159 PEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELE 218 Query: 166 NIQDTEGNTPLHLACDEERVEEAKLLVSQ 194 +++ +G TPL LA + E K ++S+ Sbjct: 219 TMRNNDGLTPLQLAAKMGKAEILKYILSR 247 >6C8G-A nrPDB Length = 675 Score = 28.9 bits (63), Expect = 2.0, Method: Compositional matrix adjust. Identities = 45/176 (25%), Positives = 68/176 (38%), Gaps = 40/176 (22%) Query: 65 PVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVM 124 P D G + LHIA V+ L+ KGA V+A + + K+ Sbjct: 95 PFRDVYYRGQTALHIAIERRCKHYVELLVEKGADVHAQARG-----RFFQPKD------- 142 Query: 125 LLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILL---YYKASTNIQDTEGNTPLH--LA 179 EGG ++ + AA ++H L + KA QD+ GNT LH +A Sbjct: 143 --EGGYF-----YFGELPLSLAACTNQPDIVHYLTENAHKKADIRRQDSRGNTVLHALVA 195 Query: 180 CDEERVEEAK-------LLVSQGASIY-------IENKEEKTPLQVAK--GGLGLI 219 + E K LLV + +Y I N + +PL +A G +G+ Sbjct: 196 IADNTRENTKFVTKVYDLLVIKCVKLYPDSSLEAIFNNDSMSPLMMAAKLGKIGIF 251 >6BBJ-A nrPDB Length = 868 Score = 28.1 bits (61), Expect = 3.5, Method: Composition-based stats. Identities = 45/178 (25%), Positives = 61/178 (34%), Gaps = 60/178 (33%) Query: 65 PVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN--------------GCTPL 110 P D G + LHIA V+ L+ KGA V+A + G PL Sbjct: 226 PFRDVYYRGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPL 285 Query: 111 HYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDT 170 AA N+ +I HY H+ KA QD+ Sbjct: 286 SLAACTNQPDIV--------------HYLTENAHK----------------KADIRRQDS 315 Query: 171 EGNTPLH--LACDEERVEEAK-------LLVSQGASIY-------IENKEEKTPLQVA 212 GNT LH +A + E K LLV + +Y I N + +PL +A Sbjct: 316 RGNTVLHALVAIADNTRENTKFVTKVYDLLVIKCVKLYPDSSLEAIFNNDSMSPLMMA 373 >6BO5-A nrPDB Length = 695 Score = 27.7 bits (60), Expect = 3.9, Method: Composition-based stats. Identities = 10/30 (33%), Positives = 21/30 (70%) Query: 171 EGNTPLHLACDEERVEEAKLLVSQGASIYI 200 +G++ LH+A ++ ++ KLLV GA +++ Sbjct: 123 QGHSALHIAIEKRSLQCVKLLVENGADVHL 152 >5HI9-A nrPDB Length = 770 Score = 27.7 bits (60), Expect = 3.9, Method: Composition-based stats. Identities = 10/30 (33%), Positives = 21/30 (70%) Query: 171 EGNTPLHLACDEERVEEAKLLVSQGASIYI 200 +G++ LH+A ++ ++ KLLV GA +++ Sbjct: 163 QGHSALHIAIEKRSLQCVKLLVENGADVHL 192 >5AN8-A nrPDB Length = 613 Score = 27.7 bits (60), Expect = 3.9, Method: Compositional matrix adjust. Identities = 27/97 (27%), Positives = 39/97 (40%), Gaps = 16/97 (16%) Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAK-------------DHYEATAM 143 AQ G + LH A K + +L+E GAN AK ++ + Sbjct: 78 AQCTDEYYRGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPL 137 Query: 144 HRAAAKGNLKMIHILL---YYKASTNIQDTEGNTPLH 177 AA +++ LL + AS QD+ GNT LH Sbjct: 138 SLAACTKQWDVVNYLLENPHPAASLQAQDSLGNTVLH 174 >2ZCI-A nrPDB Length = 610 Score = 27.7 bits (60), Expect = 4.6, Method: Compositional matrix adjust. Identities = 22/65 (33%), Positives = 29/65 (44%), Gaps = 3/65 (4%) Query: 94 GKGAQVNAVNQNGCTPLHYAASKNRHEIAV---MLLEGGANPDAKDHYEATAMHRAAAKG 150 G G NA+ C L A+ R E + ML+ NP+ K ++ A A A K Sbjct: 218 GSGYGGNAILAKKCYALRIASVMAREEGWMAEHMLILKLINPEGKAYHIAAAFPSACGKT 277 Query: 151 NLKMI 155 NL MI Sbjct: 278 NLAMI 282 >3W9G-A nrPDB Length = 260 Score = 26.9 bits (58), Expect = 7.1, Method: Compositional matrix adjust. Identities = 46/175 (26%), Positives = 65/175 (37%), Gaps = 44/175 (25%) Query: 49 SAGHTEIVEFLLQLG-----------VPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGA 97 SAG + + LL + P D G + LHIA V+ L+ KGA Sbjct: 58 SAGRNDTIPILLDIAEKTGNMREFINSPFRDVYYRGQTALHIAIERRCKHYVELLVEKGA 117 Query: 98 QVNAVNQN--------------GCTPLHYAASKNRHEIAVMLLEGG---ANPDAKDHYEA 140 V+A + G PL AA N+ I L E G A+ +D Sbjct: 118 DVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVHYLTENGHKQADLRRQDSRGN 177 Query: 141 TAMH---------RAAAKGNLKMIHILLYYKA----STNIQ---DTEGNTPLHLA 179 T +H R K KM +LL A TN++ + +G +PL +A Sbjct: 178 TVLHALVAIADNTRENTKFVTKMYDLLLIKCAKLFPDTNLEALLNNDGLSPLMMA 232 >6HEG-A nrPDB Length = 809 Score = 26.6 bits (57), Expect = 9.4, Method: Compositional matrix adjust. Identities = 19/58 (32%), Positives = 30/58 (51%), Gaps = 9/58 (15%) Query: 78 HIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAK 135 IA G+D + G GA ++A + A S++ IA +LL+G A+PDA+ Sbjct: 499 RIARRRGQDGRYQLANGMGAMLDAND---------ALSRHEWLIAPLLLQGSASPDAR 547 >6MHW-A nrPDB Length = 826 Score = 26.6 bits (57), Expect = 9.7, Method: Compositional matrix adjust. Identities = 31/119 (26%), Positives = 50/119 (42%), Gaps = 18/119 (15%) Query: 94 GKGAQVNAVNQN-----GCTPLHYAASKNRHEIAVMLLE-GGANPDAKD-------HYEA 140 KGA N Q+ G TPL AA N+ EI +L+E + ++D H Sbjct: 246 AKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALV 305 Query: 141 TAMHRAAAKGNL--KMIHILLYYKASTNIQDTEGN---TPLHLACDEERVEEAKLLVSQ 194 T + + +M ++L + ++ T N TPL LA + E K ++S+ Sbjct: 306 TVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSR 364 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4NIK-A nrPDB 283 4e-77 2DWZ-A nrPDB 283 5e-77 6BY9-A nrPDB 207 3e-54 3B7B-A nrPDB 202 8e-53 5AQ9-A nrPDB 190 3e-49 6AUN-A nrPDB 190 5e-49 5AQB-A nrPDB 188 2e-48 4OAU-C nrPDB 187 5e-48 5JHQ-A nrPDB 185 1e-47 6MWQ-A nrPDB 185 2e-47 5AQA-A nrPDB 185 2e-47 5MIO-C nrPDB 184 4e-47 5AQ7-A nrPDB 182 1e-46 6FES-A nrPDB 181 2e-46 1WG0-A nrPDB 179 7e-46 5H76-A nrPDB 170 5e-43 5HKP-A nrPDB 169 1e-42 3ZKJ-A nrPDB 163 5e-41 4O1O-A nrPDB 161 2e-40 5ET1-A nrPDB 159 8e-40 3EU9-A nrPDB 157 5e-39 4OT9-A nrPDB 152 8e-38 5CBO-A nrPDB 143 4e-35 4Z68-A nrPDB 143 6e-35 5GP7-A nrPDB 134 3e-32 6EMK-G nrPDB 131 3e-31 3LJN-A nrPDB 126 1e-29 6BOA-A nrPDB 120 6e-28 5D68-A nrPDB 117 3e-27 5DND-A nrPDB 116 9e-27 6E2G-A nrPDB 115 2e-26 1BLX-B nrPDB 110 6e-25 1BD8-A nrPDB 108 3e-24 6DMR-A nrPDB 102 1e-22 4BSZ-B nrPDB 100 5e-22 5UIL-A nrPDB 99 1e-21 1G3N-B nrPDB 97 6e-21 3UI2-A nrPDB 97 6e-21 3DEO-A nrPDB 96 1e-20 2KXP-C nrPDB 95 2e-20 3T9K-A nrPDB 94 4e-20 3EHQ-A nrPDB 88 3e-18 5UQE-A nrPDB 87 5e-18 5U0K-A nrPDB 87 8e-18 5U0J-A nrPDB 83 1e-16 4XD0-A nrPDB 83 1e-16 1DCQ-A nrPDB 78 3e-15 Sequences not found previously or not previously below threshold: 2RFA-A nrPDB 103 6e-23 5AN8-A nrPDB 77 7e-15 6OO7-A nrPDB 76 1e-14 1D9S-A nrPDB 75 3e-14 5IRX-A nrPDB 72 2e-13 6DVZ-A nrPDB 71 3e-13 2A5E-A nrPDB 71 5e-13 6BO5-A nrPDB 70 6e-13 5HI9-A nrPDB 70 6e-13 2F37-A nrPDB 68 3e-12 2NYJ-A nrPDB 67 5e-12 4N5Q-A nrPDB 67 1e-11 2ETB-A nrPDB 65 2e-11 6CV9-A nrPDB 65 3e-11 3LVQ-E nrPDB 64 5e-11 6CUD-A nrPDB 63 1e-10 2B0O-E nrPDB 62 2e-10 6C8G-A nrPDB 62 3e-10 6BBJ-A nrPDB 62 3e-10 6MHW-A nrPDB 60 8e-10 4DX2-A nrPDB 59 1e-09 6DJS-A nrPDB 59 2e-09 3W9G-A nrPDB 59 2e-09 6G1K-A nrPDB 58 3e-09 4CJ9-A nrPDB 44 6e-05 5Z96-A nrPDB 43 7e-05 6BWI-A nrPDB 36 0.010 1EV4-A nrPDB 30 1.1 2DI3-A nrPDB 29 1.7 6GC1-A nrPDB 28 4.8 3WQO-A nrPDB 27 6.3 >4NIK-A nrPDB Length = 230 Score = 283 bits (725), Expect = 4e-77, Method: Composition-based stats. Identities = 226/226 (100%), Positives = 226/226 (100%) Query: 1 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL Sbjct: 5 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 64 Query: 61 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 120 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE Sbjct: 65 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 124 Query: 121 IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC 180 IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC Sbjct: 125 IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC 184 Query: 181 DEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG 226 DEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG Sbjct: 185 DEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG 230 >2DWZ-A nrPDB Length = 231 Score = 283 bits (723), Expect = 5e-77, Method: Composition-based stats. Identities = 213/226 (94%), Positives = 221/226 (97%) Query: 1 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60 MEGCVSN+M+CNLAYSGKL+ELKE ILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL Sbjct: 1 MEGCVSNIMICNLAYSGKLDELKERILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60 Query: 61 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 120 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL KGA VNAVNQNGCTPLHYAASKNRHE Sbjct: 61 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLVKGAHVNAVNQNGCTPLHYAASKNRHE 120 Query: 121 IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC 180 IAVMLLEGGANPDAKDHY+ATAMHRAAAKGNLKM+HILL+YKASTNIQDTEGNTPLHLAC Sbjct: 121 IAVMLLEGGANPDAKDHYDATAMHRAAAKGNLKMVHILLFYKASTNIQDTEGNTPLHLAC 180 Query: 181 DEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG 226 DEERVEEAK LV+QGASIYIENKEEKTPLQVAKGGLGLILKR+ EG Sbjct: 181 DEERVEEAKFLVTQGASIYIENKEEKTPLQVAKGGLGLILKRLAEG 226 >6BY9-A nrPDB Length = 328 Score = 207 bits (527), Expect = 3e-54, Method: Composition-based stats. Identities = 64/213 (30%), Positives = 109/213 (51%), Gaps = 2/213 (0%) Query: 1 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60 ME + A +G ++ + ++ + +D RT L A H E V++L+ Sbjct: 97 MEHQNKRSPLHAAAEAGHVD-ICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI 155 Query: 61 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGA-QVNAVNQNGCTPLHYAASKNRH 119 + G V+ KD G + LH+AA G E+V+ LL G VN + G TP+ +A Sbjct: 156 KAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHV 215 Query: 120 EIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179 ++ +LL G++ + +D+ E +H AA G + + ILL K + + G++PLH+A Sbjct: 216 DLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIA 275 Query: 180 CDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212 E R + L +S+ + + ++NKE +TPLQ A Sbjct: 276 ARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 308 Score = 155 bits (392), Expect = 1e-38, Method: Composition-based stats. Identities = 58/202 (28%), Positives = 98/202 (48%), Gaps = 2/202 (0%) Query: 14 AYSGKLEELKESILADKSLATRTD-QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA 72 A G+L+++ ++ + + Q+ R+ LH A AGH +I L+Q G ++ + Sbjct: 75 ARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSED 134 Query: 73 GWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG-AN 131 +PL AA E VK L+ GA V+ + G T LH AA K +E+ LL G + Sbjct: 135 QRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMD 194 Query: 132 PDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLL 191 + +D T M A ++ ++ +LL + NI+D E N LH A V+ A++L Sbjct: 195 VNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEIL 254 Query: 192 VSQGASIYIENKEEKTPLQVAK 213 ++ ++ N +PL +A Sbjct: 255 LAAKCDLHAVNIHGDSPLHIAA 276 Score = 151 bits (382), Expect = 2e-37, Method: Composition-based stats. Identities = 52/178 (29%), Positives = 87/178 (48%), Gaps = 2/178 (1%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLG-VPVN 67 + A + LE +K ++ +L D + T LH A GH E+V++LL G + VN Sbjct: 138 PLMEAAENNHLEAVK-YLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVN 196 Query: 68 DKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLE 127 +DD GW+P+ A ++VK LL KG+ +N + LH+AA +IA +LL Sbjct: 197 CQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLA 256 Query: 128 GGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV 185 + A + + + +H AA + + + L + +++ EG TPL A +V Sbjct: 257 AKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQV 314 Score = 142 bits (357), Expect = 2e-34, Method: Composition-based stats. Identities = 63/208 (30%), Positives = 102/208 (49%), Gaps = 3/208 (1%) Query: 20 EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK--DDAGWSPL 77 E L+ +++A S + + L+++ G + V +L G+ N K SPL Sbjct: 47 ETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPL 106 Query: 78 HIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDH 137 H AA AG +I L+ GA ++ +++ TPL AA N E L++ GA D KD Sbjct: 107 HAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDA 166 Query: 138 YEATAMHRAAAKGNLKMIHILLYYKA-STNIQDTEGNTPLHLACDEERVEEAKLLVSQGA 196 +T +H AA KG+ +++ LL N QD G TP+ A + + V+ KLL+S+G+ Sbjct: 167 EGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGS 226 Query: 197 SIYIENKEEKTPLQVAKGGLGLILKRMV 224 I I + EE L A + + ++ Sbjct: 227 DINIRDNEENICLHWAAFSGCVDIAEIL 254 >3B7B-A nrPDB Length = 237 Score = 202 bits (515), Expect = 8e-53, Method: Composition-based stats. Identities = 64/213 (30%), Positives = 109/213 (51%), Gaps = 2/213 (0%) Query: 1 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60 ME + A +G ++ + ++ + +D RT L A H E V++L+ Sbjct: 6 MEHQNKRSPLHAAAEAGHVD-ICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLI 64 Query: 61 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGA-QVNAVNQNGCTPLHYAASKNRH 119 + G V+ KD G + LH+AA G E+V+ LL G VN + G TP+ +A Sbjct: 65 KAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHV 124 Query: 120 EIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179 ++ +LL G++ + +D+ E +H AA G + + ILL K + + G++PLH+A Sbjct: 125 DLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIA 184 Query: 180 CDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212 E R + L +S+ + + ++NKE +TPLQ A Sbjct: 185 ARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 217 Score = 148 bits (373), Expect = 2e-36, Method: Composition-based stats. Identities = 52/178 (29%), Positives = 87/178 (48%), Gaps = 2/178 (1%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLG-VPVN 67 + A + LE +K ++ +L D + T LH A GH E+V++LL G + VN Sbjct: 47 PLMEAAENNHLEAVK-YLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVN 105 Query: 68 DKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLE 127 +DD GW+P+ A ++VK LL KG+ +N + LH+AA +IA +LL Sbjct: 106 CQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLA 165 Query: 128 GGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV 185 + A + + + +H AA + + + L + +++ EG TPL A +V Sbjct: 166 AKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQV 223 Score = 125 bits (313), Expect = 2e-29, Method: Composition-based stats. Identities = 52/152 (34%), Positives = 79/152 (51%), Gaps = 1/152 (0%) Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133 SPLH AA AG +I L+ GA ++ +++ TPL AA N E L++ GA D Sbjct: 12 RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVD 71 Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKA-STNIQDTEGNTPLHLACDEERVEEAKLLV 192 KD +T +H AA KG+ +++ LL N QD G TP+ A + + V+ KLL+ Sbjct: 72 PKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLL 131 Query: 193 SQGASIYIENKEEKTPLQVAKGGLGLILKRMV 224 S+G+ I I + EE L A + + ++ Sbjct: 132 SKGSDINIRDNEENICLHWAAFSGCVDIAEIL 163 Score = 95.8 bits (237), Expect = 1e-20, Method: Composition-based stats. Identities = 36/122 (29%), Positives = 60/122 (49%), Gaps = 1/122 (0%) Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163 QN +PLH AA +I ML++ GAN D + T + AA +L+ + L+ A Sbjct: 9 QNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGA 68 Query: 164 STNIQDTEGNTPLHLACDEERVEEAKLLVSQGA-SIYIENKEEKTPLQVAKGGLGLILKR 222 + +D EG+T LHLA + E + L+S G + ++ TP+ A + L + Sbjct: 69 LVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVK 128 Query: 223 MV 224 ++ Sbjct: 129 LL 130 Score = 43.0 bits (100), Expect = 9e-05, Method: Composition-based stats. Identities = 14/48 (29%), Positives = 26/48 (54%) Query: 167 IQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKG 214 ++ +PLH A + V+ +LV GA+I +++++TPL A Sbjct: 6 MEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAE 53 >5AQ9-A nrPDB Length = 422 Score = 190 bits (484), Expect = 3e-49, Method: Composition-based stats. Identities = 56/149 (37%), Positives = 85/149 (57%) Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136 L AA AG+D+ V+ L+ GA VNA + G TPLH AA EI +LL+ GA+ DA D Sbjct: 18 LLEAARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASD 77 Query: 137 HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGA 196 + T +H AA G+L+++ +LL A N D++G TPLHLA +E ++L+ GA Sbjct: 78 VFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEIVEVLLKHGA 137 Query: 197 SIYIENKEEKTPLQVAKGGLGLILKRMVE 225 + ++K KTP +A + +++ Sbjct: 138 DVNAQDKFGKTPFDLADDNGNDDVGTLLQ 166 Score = 183 bits (465), Expect = 4e-47, Method: Composition-based stats. Identities = 63/155 (40%), Positives = 84/155 (54%), Gaps = 1/155 (0%) Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103 L A AG + V L+ G VN D+ G +PLH+AA +G EIV+ LL GA V+A + Sbjct: 18 LLEAARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASD 77 Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163 G TPLH AA EI +LL+ GA+ +A D T +H AA G L+++ +LL + A Sbjct: 78 VFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEIVEVLLKHGA 137 Query: 164 STNIQDTEGNTPLHLACDEERVEEAKLL-VSQGAS 197 N QD G TP LA D + LL V+ A Sbjct: 138 DVNAQDKFGKTPFDLADDNGNDDVGTLLQVAAAAD 172 Score = 176 bits (447), Expect = 6e-45, Method: Composition-based stats. Identities = 57/149 (38%), Positives = 85/149 (57%), Gaps = 1/149 (0%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 + A +G+ +E++ ++A+ + D T LH A +GH EIVE LL+ G V+ Sbjct: 18 LLEAARAGQDDEVR-ILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDAS 76 Query: 70 DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG 129 D G++PLH+AA G EIV+ LL GA VNA++ +G TPLH AA EI +LL+ G Sbjct: 77 DVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEIVEVLLKHG 136 Query: 130 ANPDAKDHYEATAMHRAAAKGNLKMIHIL 158 A+ +A+D + T A GN + +L Sbjct: 137 ADVNAQDKFGKTPFDLADDNGNDDVGTLL 165 Score = 123 bits (310), Expect = 5e-29, Method: Composition-based stats. Identities = 48/137 (35%), Positives = 63/137 (45%), Gaps = 1/137 (0%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVND 68 + AYSG L E+ E +L + +D T LH A GH EIVE LL+ G VN Sbjct: 50 PLHLAAYSGHL-EIVEVLLKHGADVDASDVFGYTPLHLAAYWGHLEIVEVLLKNGADVNA 108 Query: 69 KDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG 128 D G +PLH+AA G EIV+ LL GA VNA ++ G TP A ++ +L Sbjct: 109 MDSDGMTPLHLAAKWGYLEIVEVLLKHGADVNAQDKFGKTPFDLADDNGNDDVGTLLQVA 168 Query: 129 GANPDAKDHYEATAMHR 145 A + Sbjct: 169 AAADQLGARVGYIELDL 185 >6AUN-A nrPDB Length = 752 Score = 190 bits (482), Expect = 5e-49, Method: Composition-based stats. Identities = 66/253 (26%), Positives = 106/253 (41%), Gaps = 41/253 (16%) Query: 2 EGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61 EGC + C S L EL + A + TD TA H+A ++++++ L + Sbjct: 151 EGCTPLHLACRKGDSEILVELVQYCHAQMDV---TDNKGETAFHYAVQGDNSQVLQLLGK 207 Query: 62 LG-VPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGC------------- 107 +N + G +PLH+A G+ E+V+ LL A+ N + +G Sbjct: 208 NASAGLNQVNKQGLTPLHLACQMGKQEMVRVLLLCNARCNVMGPSGFPIHTAMKFSQKGC 267 Query: 108 ---------------------TPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146 +PLH+A E+A MLL+ G + D+ TA+H A Sbjct: 268 AEMIISMDSSQIHSKDPRYGASPLHWA---KNAEMARMLLKRGCDVDSTSAAGNTALHVA 324 Query: 147 AAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEK 206 + + +LL Y A+ GNTPLHLA ++ +E K L+ GA + N + Sbjct: 325 VMRNRFDCVMVLLTYGANAGTPGEHGNTPLHLAISKDNMEMIKALIVFGAEVDTPNDFGE 384 Query: 207 TPLQVAKGGLGLI 219 TP +A + Sbjct: 385 TPAFMASKISKQL 397 Score = 91.6 bits (226), Expect = 2e-19, Method: Composition-based stats. Identities = 45/163 (27%), Positives = 69/163 (42%), Gaps = 8/163 (4%) Query: 52 HTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLH 111 H E+++ L + + W+ H+A G E + N+ GCTPLH Sbjct: 103 HVEVLQHL----SDL-IRSHPSWTVTHLAVELGIRECFHHSRIISCANSTENEEGCTPLH 157 Query: 112 YAASKNRHEIAVMLLEG-GANPDAKDHYEATAMHRAAAKGNLKMIHILLYY-KASTNIQD 169 A K EI V L++ A D D+ TA H A N +++ +L A N + Sbjct: 158 LACRKGDSEILVELVQYCHAQMDVTDNKGETAFHYAVQGDNSQVLQLLGKNASAGLNQVN 217 Query: 170 TEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212 +G TPLHLAC + E ++L+ A + P+ A Sbjct: 218 KQGLTPLHLACQMGKQEMVRVLLLCNARCNVMGPSGF-PIHTA 259 Score = 70.8 bits (172), Expect = 5e-13, Method: Composition-based stats. Identities = 27/120 (22%), Positives = 47/120 (39%), Gaps = 2/120 (1%) Query: 107 CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY-KAST 165 T H A E ++ T +H A KG+ +++ L+ Y A Sbjct: 120 WTVTHLAVELGIRECFHHSRIISCANSTENEEGCTPLHLACRKGDSEILVELVQYCHAQM 179 Query: 166 NIQDTEGNTPLHLACDEERVEEAKLLVSQ-GASIYIENKEEKTPLQVAKGGLGLILKRMV 224 ++ D +G T H A + + +LL A + NK+ TPL +A + R++ Sbjct: 180 DVTDNKGETAFHYAVQGDNSQVLQLLGKNASAGLNQVNKQGLTPLHLACQMGKQEMVRVL 239 Score = 50.8 bits (120), Expect = 5e-07, Method: Composition-based stats. Identities = 23/100 (23%), Positives = 42/100 (42%), Gaps = 2/100 (2%) Query: 126 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV 185 L+ ++ + H T H A G + H + + ++ EG TPLHLAC + Sbjct: 107 LQHLSDL-IRSHPSWTVTHLAVELGIRECFHHSRIISCANSTENEEGCTPLHLACRKGDS 165 Query: 186 EEAKLLVSQ-GASIYIENKEEKTPLQVAKGGLGLILKRMV 224 E LV A + + + + +T A G + +++ Sbjct: 166 EILVELVQYCHAQMDVTDNKGETAFHYAVQGDNSQVLQLL 205 >5AQB-A nrPDB Length = 428 Score = 188 bits (477), Expect = 2e-48, Method: Composition-based stats. Identities = 62/159 (38%), Positives = 87/159 (54%), Gaps = 1/159 (0%) Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103 L A AG + L+ G VN D+ GW+PLH+AA G EIV+ LL GA VNA + Sbjct: 18 LLEAARAGQDDECRILMANGADVNALDEVGWTPLHLAAW-GHLEIVECLLKNGADVNAAD 76 Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163 +G TPLH AA EI +LL+ GA+ +A D T +H AA G+L+++ +LL A Sbjct: 77 IDGYTPLHLAAFSGHLEIVEVLLKYGADVNADDQAGFTPLHLAAIFGHLEIVEVLLKNGA 136 Query: 164 STNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIEN 202 N QD G TP LA D + A++L + +++ Sbjct: 137 DVNAQDKFGKTPRDLAIDNGNEDIAEVLGKAATLVKVKD 175 Score = 171 bits (434), Expect = 2e-43, Method: Composition-based stats. Identities = 55/148 (37%), Positives = 82/148 (55%), Gaps = 1/148 (0%) Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136 L AA AG+D+ + L+ GA VNA+++ G TPLH AA EI LL+ GA+ +A D Sbjct: 18 LLEAARAGQDDECRILMANGADVNALDEVGWTPLHLAAW-GHLEIVECLLKNGADVNAAD 76 Query: 137 HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGA 196 T +H AA G+L+++ +LL Y A N D G TPLHLA +E ++L+ GA Sbjct: 77 IDGYTPLHLAAFSGHLEIVEVLLKYGADVNADDQAGFTPLHLAAIFGHLEIVEVLLKNGA 136 Query: 197 SIYIENKEEKTPLQVAKGGLGLILKRMV 224 + ++K KTP +A + ++ Sbjct: 137 DVNAQDKFGKTPRDLAIDNGNEDIAEVL 164 Score = 170 bits (432), Expect = 3e-43, Method: Composition-based stats. Identities = 72/219 (32%), Positives = 106/219 (48%), Gaps = 11/219 (5%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 + A +G+ +E + ++A+ + D+ T LH A GH EIVE LL+ G VN Sbjct: 18 LLEAARAGQDDECR-ILMANGADVNALDEVGWTPLHLAA-WGHLEIVECLLKNGADVNAA 75 Query: 70 DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG 129 D G++PLH+AA +G EIV+ LL GA VNA +Q G TPLH AA EI +LL+ G Sbjct: 76 DIDGYTPLHLAAFSGHLEIVEVLLKYGADVNADDQAGFTPLHLAAIFGHLEIVEVLLKNG 135 Query: 130 ANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAK 189 A+ +A+D + T A GN + +L ++D L + Sbjct: 136 ADVNAQDKFGKTPRDLAIDNGNEDIAEVLGKAATLVKVKDAADQ----LGARVGY---IE 188 Query: 190 LLVSQGASIYIENKEEKTPLQVAKGGL--GLILKRMVEG 226 L ++ G + EE+ P+ L G IL R+ G Sbjct: 189 LDLNSGKILESFRSEERFPMMSTFKVLLAGAILSRIDAG 227 >4OAU-C nrPDB Length = 699 Score = 187 bits (474), Expect = 5e-48, Method: Composition-based stats. Identities = 64/236 (27%), Positives = 108/236 (45%), Gaps = 18/236 (7%) Query: 7 NLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPV 66 N ++ + ++ +++ + ++ + ++ T LH A +IVE LL+ G Sbjct: 6 NHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADP 65 Query: 67 NDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLL 126 + G +P +AA AG +++K L KGA VN + G T AA + + L Sbjct: 66 VLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLY 125 Query: 127 EGGANPDAKDHY----------EATAMHRAAAKGNLKMIHILL-YYKASTNIQDTEGNTP 175 + GAN + + ATA+ AA KG+++++ ILL A N D G Sbjct: 126 KRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNA 185 Query: 176 LHLAC----DEERVEEAKLLVSQGASIYIENKEEKTPLQVA--KGGLGLILKRMVE 225 L A D + LL+ GA + + + KTPL +A K LGL+ +R++E Sbjct: 186 LIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLV-QRLLE 240 Score = 131 bits (330), Expect = 2e-31, Method: Composition-based stats. Identities = 55/210 (26%), Positives = 91/210 (43%), Gaps = 17/210 (8%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVND 68 A +G + +L + L+ + D TA A G + ++FL + G VN Sbjct: 75 PFILAAIAGSV-KLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNL 133 Query: 69 KDD----------AGWSPLHIAASAGRDEIVKALLGK-GAQVNAVNQNGCTPLHYAASKN 117 + G + L AA G E++K LL + GA VNA + G L +A + Sbjct: 134 RRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSS 193 Query: 118 RHE----IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK-ASTNIQDTEG 172 I +LL+ GA+ + + T + A K +L ++ LL + N D++G Sbjct: 194 DDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDG 253 Query: 173 NTPLHLACDEERVEEAKLLVSQGASIYIEN 202 T L LA + + + A+LL +GAS + Sbjct: 254 KTALLLAVELKLKKIAELLCKRGASTDCGD 283 Score = 105 bits (263), Expect = 1e-23, Method: Composition-based stats. Identities = 56/203 (27%), Positives = 81/203 (39%), Gaps = 22/203 (10%) Query: 10 VCNLAYSGKLEELKESILADKSLAT-----RTDQD-----SRTALHWACSAGHTEIVEFL 59 A GK++ LK + + + DQ+ TAL A GH E+++ L Sbjct: 109 FMEAAVYGKVKALK-FLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKIL 167 Query: 60 L-QLGVPVNDKDDAGWSPLHIAASAGRDEIVK----ALLGKGAQVNAVNQNGCTPLHYAA 114 L ++G VN D+ G + L A + D V+ LL GA VN + G TPL A Sbjct: 168 LDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAV 227 Query: 115 SKNRHEIAVMLLEGGA-NPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGN 173 K + LLE + D TA+ A K+ +L AST+ D Sbjct: 228 EKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDL--- 284 Query: 174 TPLHLACDEERVEEAKLLVSQGA 196 + A K+L+S GA Sbjct: 285 --VMTARRNYDHSLVKVLLSHGA 305 Score = 71.9 bits (175), Expect = 2e-13, Method: Composition-based stats. Identities = 25/91 (27%), Positives = 43/91 (47%), Gaps = 3/91 (3%) Query: 139 EATAMHRAAAKGNLKMIHILLYYKASTNIQDTE-GNTPLHLACDEERVEEAKLLVSQGAS 197 + + +A ++ ++ LL A+ N Q+ E G TPLH A R + +LL+ GA Sbjct: 5 DNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGAD 64 Query: 198 IYIENKEEKTPLQVA--KGGLGLILKRMVEG 226 + K TP +A G + L+ + +G Sbjct: 65 PVLRKKNGATPFILAAIAGSVKLLKLFLSKG 95 Score = 45.4 bits (106), Expect = 2e-05, Method: Composition-based stats. Identities = 21/96 (21%), Positives = 35/96 (36%), Gaps = 8/96 (8%) Query: 3 GCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQL 62 G ++ + G ++ + + TD D +TAL A +I E L + Sbjct: 219 GKTPLILAVEKKHLGL---VQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKR 275 Query: 63 GVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98 G + D + A +VK LL GA+ Sbjct: 276 GASTDCGD-----LVMTARRNYDHSLVKVLLSHGAK 306 >5JHQ-A nrPDB Length = 482 Score = 185 bits (469), Expect = 1e-47, Method: Composition-based stats. Identities = 69/226 (30%), Positives = 109/226 (48%), Gaps = 25/226 (11%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSR--TALHWACSAGHTEIVEFLLQLGVPVN 67 + +G + +K L D + D R + LH+A G ++VE LLQ+G V+ Sbjct: 19 LLEACRNGDVSRVKR--LVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVH 76 Query: 68 DKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLE 127 +DD G PLH A S G E+V LL +GA NA + TPLH AA K + ++ ++LL+ Sbjct: 77 ARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ 136 Query: 128 GGANPDAKDHYEATAMHR--------------------AAAKGNLK-MIHILLYYKASTN 166 GA+P+ ++ +A+ AA GN + ++ +L + + Sbjct: 137 HGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCH 196 Query: 167 IQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212 D +TPLHLA RV +LL+ GA ++ ++K PL A Sbjct: 197 ASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNA 242 Score = 169 bits (429), Expect = 8e-43, Method: Composition-based stats. Identities = 71/239 (29%), Positives = 106/239 (44%), Gaps = 24/239 (10%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 + A SG E+L + +D T LH A IV+ LLQ G V+ K Sbjct: 172 LLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK 231 Query: 70 DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG 129 D G PLH A S G E+ + LL GA VNA++ TPLH AASKNR E+ +LL G Sbjct: 232 DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHG 291 Query: 130 ANPDAKD---------------------HYEATAMHRAAAKGNLKMIHILLYYKASTNIQ 168 A+P + ++ ++ +AA + +L + L + Q Sbjct: 292 ADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQ 351 Query: 169 DTEGNTPLHLA---CDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMV 224 T LH A +R + +LL+ +GA++ +NK+ TPL VA + ++ Sbjct: 352 PQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL 410 Score = 136 bits (343), Expect = 7e-33, Method: Composition-based stats. Identities = 65/204 (31%), Positives = 98/204 (48%), Gaps = 24/204 (11%) Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGW--SPLHIAASAGRDEIVKALLGKGAQVNA 101 L AC G V+ L+ VN KD AG SPLH AA GR ++V+ LL GA V+A Sbjct: 19 LLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 77 Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161 + G PLH A S E+ +LL GA+P+A+D++ T +H AA KG + + +LL + Sbjct: 78 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 137 Query: 162 KASTNIQDTEGNTPLHLA--------------------CDEERVE-EAKLLVSQGASIYI 200 A NI++T+G + L LA E LL + + Sbjct: 138 GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA 197 Query: 201 ENKEEKTPLQVAKGGLGLILKRMV 224 + + TPL +A G + + +++ Sbjct: 198 SDGRKSTPLHLAAGYNRVRIVQLL 221 Score = 118 bits (296), Expect = 2e-27, Method: Composition-based stats. Identities = 57/240 (23%), Positives = 87/240 (36%), Gaps = 25/240 (10%) Query: 7 NLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPV 66 + + N G E+ E +L + D T LH A S E+ LL G Sbjct: 236 LVPLHNACSYGHY-EVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADP 294 Query: 67 NDKDDAGWSP---------------------LHIAASAGRDEIVKALLGKGAQVNAVNQN 105 + G S L AA VK L Q+ Sbjct: 295 TLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQS 354 Query: 106 GCTPLHYAASKNRHE---IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK 162 T LH A + + + +LL GAN + K+ T +H AA + + ++ +L + Sbjct: 355 HETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG 414 Query: 163 ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKR 222 A N DT G T LH A ++ +LL+S G+ I + + T Q+ + IL Sbjct: 415 AKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSE 474 >6MWQ-A nrPDB Length = 493 Score = 185 bits (469), Expect = 2e-47, Method: Composition-based stats. Identities = 58/148 (39%), Positives = 81/148 (54%) Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103 L A AG + V L+ G VN D G +PLH+AA G EIV+ LL GA VNA + Sbjct: 9 LLEAARAGQDDEVRILMANGADVNALDRFGLTPLHLAAQRGHLEIVEVLLKCGADVNAAD 68 Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163 G TPLH AA+ EI +LL+ GA+ +A D T +H A G+L+++ +LL + A Sbjct: 69 LWGQTPLHLAATAGHLEIVEVLLKYGADVNALDLIGKTPLHLTAIDGHLEIVEVLLKHGA 128 Query: 164 STNIQDTEGNTPLHLACDEERVEEAKLL 191 N QD G T ++ D + A++L Sbjct: 129 DVNAQDKFGKTAFDISIDNGNEDLAEIL 156 Score = 179 bits (455), Expect = 6e-46, Method: Composition-based stats. Identities = 54/149 (36%), Positives = 86/149 (57%) Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136 L AA AG+D+ V+ L+ GA VNA+++ G TPLH AA + EI +LL+ GA+ +A D Sbjct: 9 LLEAARAGQDDEVRILMANGADVNALDRFGLTPLHLAAQRGHLEIVEVLLKCGADVNAAD 68 Query: 137 HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGA 196 + T +H AA G+L+++ +LL Y A N D G TPLHL + +E ++L+ GA Sbjct: 69 LWGQTPLHLAATAGHLEIVEVLLKYGADVNALDLIGKTPLHLTAIDGHLEIVEVLLKHGA 128 Query: 197 SIYIENKEEKTPLQVAKGGLGLILKRMVE 225 + ++K KT ++ L +++ Sbjct: 129 DVNAQDKFGKTAFDISIDNGNEDLAEILQ 157 Score = 173 bits (438), Expect = 7e-44, Method: Composition-based stats. Identities = 72/209 (34%), Positives = 103/209 (49%), Gaps = 9/209 (4%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 + A +G+ +E++ ++A+ + D+ T LH A GH EIVE LL+ G VN Sbjct: 9 LLEAARAGQDDEVR-ILMANGADVNALDRFGLTPLHLAAQRGHLEIVEVLLKCGADVNAA 67 Query: 70 DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG 129 D G +PLH+AA+AG EIV+ LL GA VNA++ G TPLH A EI +LL+ G Sbjct: 68 DLWGQTPLHLAATAGHLEIVEVLLKYGADVNALDLIGKTPLHLTAIDGHLEIVEVLLKHG 127 Query: 130 ANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK-ASTNIQ---DTEGNTPLHLACDEERV 185 A+ +A+D + TA + GN + IL + + +G LA DE Sbjct: 128 ADVNAQDKFGKTAFDISIDNGNEDLAEILQKLNLSDIAHRIVAPGKGI----LAADESTG 183 Query: 186 EEAKLLVSQGASIYIENKEEKTPLQVAKG 214 AK L S G EN+ L + Sbjct: 184 SIAKRLQSIGTENTEENRRFYRQLLLTAD 212 >5AQA-A nrPDB Length = 418 Score = 185 bits (469), Expect = 2e-47, Method: Composition-based stats. Identities = 56/138 (40%), Positives = 80/138 (57%) Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136 L AA AG+D+ V+ L+ GA VNA + G TPLH AA EI +LL+ GA+ DA D Sbjct: 18 LLEAARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASD 77 Query: 137 HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGA 196 + T +H AA G+L+++ +LL A N D++G TPLHLA E ++L+ GA Sbjct: 78 VFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYKEIVEVLLKAGA 137 Query: 197 SIYIENKEEKTPLQVAKG 214 + ++K K PL +A Sbjct: 138 DVDAQDKFGKRPLWLAAD 155 Score = 183 bits (464), Expect = 6e-47, Method: Composition-based stats. Identities = 61/151 (40%), Positives = 82/151 (54%) Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103 L A AG + V L+ G VN D+ G +PLH+AA +G EIV+ LL GA V+A + Sbjct: 18 LLEAARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASD 77 Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163 G TPLH AA EI +LL+ GA+ +A D T +H AA G +++ +LL A Sbjct: 78 VFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYKEIVEVLLKAGA 137 Query: 164 STNIQDTEGNTPLHLACDEERVEEAKLLVSQ 194 + QD G PL LA D+ E A LV+ Sbjct: 138 DVDAQDKFGKRPLWLAADQGHAEIAAKLVAA 168 Score = 175 bits (445), Expect = 9e-45, Method: Composition-based stats. Identities = 57/153 (37%), Positives = 89/153 (58%), Gaps = 1/153 (0%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 + A +G+ +E++ ++A+ + D T LH A +GH EIVE LL+ G V+ Sbjct: 18 LLEAARAGQDDEVR-ILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDAS 76 Query: 70 DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG 129 D G++PLH+AA G EIV+ LL GA VNA++ +G TPLH AA EI +LL+ G Sbjct: 77 DVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYKEIVEVLLKAG 136 Query: 130 ANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK 162 A+ DA+D + + AA +G+ ++ L+ + Sbjct: 137 ADVDAQDKFGKRPLWLAADQGHAEIAAKLVAAR 169 Score = 41.9 bits (97), Expect = 2e-04, Method: Composition-based stats. Identities = 10/46 (21%), Positives = 22/46 (47%) Query: 179 ACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMV 224 A + +E ++L++ GA + + TPL +A L + ++ Sbjct: 21 AARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVL 66 >5MIO-C nrPDB Length = 573 Score = 184 bits (466), Expect = 4e-47, Method: Composition-based stats. Identities = 58/148 (39%), Positives = 81/148 (54%) Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103 L A AG + V L+ G VN D +G +PLH+AA+ G EIV+ LL GA V+A + Sbjct: 414 LLEAARAGQDDEVRVLMANGADVNATDASGLTPLHLAATYGHLEIVEVLLKHGADVSASD 473 Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163 G TPLH AA EI +LL+ GA+ +A D + T + AA G+LK++ LL + A Sbjct: 474 LMGSTPLHLAALIGHLEIVEVLLKHGADVNAVDTWGDTPLRLAAVMGHLKIVEALLKHGA 533 Query: 164 STNIQDTEGNTPLHLACDEERVEEAKLL 191 N QD G T + D + A++L Sbjct: 534 DVNAQDKFGKTAYDTSIDNGSEDLAEIL 561 Score = 172 bits (437), Expect = 9e-44, Method: Composition-based stats. Identities = 53/149 (35%), Positives = 83/149 (55%) Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136 L AA AG+D+ V+ L+ GA VNA + +G TPLH AA+ EI +LL+ GA+ A D Sbjct: 414 LLEAARAGQDDEVRVLMANGADVNATDASGLTPLHLAATYGHLEIVEVLLKHGADVSASD 473 Query: 137 HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGA 196 +T +H AA G+L+++ +LL + A N DT G+TPL LA ++ + L+ GA Sbjct: 474 LMGSTPLHLAALIGHLEIVEVLLKHGADVNAVDTWGDTPLRLAAVMGHLKIVEALLKHGA 533 Query: 197 SIYIENKEEKTPLQVAKGGLGLILKRMVE 225 + ++K KT + L +++ Sbjct: 534 DVNAQDKFGKTAYDTSIDNGSEDLAEILQ 562 Score = 170 bits (432), Expect = 3e-43, Method: Composition-based stats. Identities = 57/149 (38%), Positives = 83/149 (55%), Gaps = 1/149 (0%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 + A +G+ +E++ ++A+ + TD T LH A + GH EIVE LL+ G V+ Sbjct: 414 LLEAARAGQDDEVR-VLMANGADVNATDASGLTPLHLAATYGHLEIVEVLLKHGADVSAS 472 Query: 70 DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG 129 D G +PLH+AA G EIV+ LL GA VNAV+ G TPL AA +I LL+ G Sbjct: 473 DLMGSTPLHLAALIGHLEIVEVLLKHGADVNAVDTWGDTPLRLAAVMGHLKIVEALLKHG 532 Query: 130 ANPDAKDHYEATAMHRAAAKGNLKMIHIL 158 A+ +A+D + TA + G+ + IL Sbjct: 533 ADVNAQDKFGKTAYDTSIDNGSEDLAEIL 561 >5AQ7-A nrPDB Length = 418 Score = 182 bits (461), Expect = 1e-46, Method: Composition-based stats. Identities = 61/151 (40%), Positives = 80/151 (52%) Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103 L A AG + V LL G VN D+ G++PLH+AA G IV+ LL GA VNA + Sbjct: 18 LLEAARAGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNAND 77 Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163 + G TPLH AA EI +LL+ GA +A D +H AA G +++ +LL A Sbjct: 78 ERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGYKEIVEVLLKAGA 137 Query: 164 STNIQDTEGNTPLHLACDEERVEEAKLLVSQ 194 + QD G PL LA D+ E A LV+ Sbjct: 138 DVDAQDKFGKRPLWLAADQGHAEIAAKLVAA 168 Score = 170 bits (431), Expect = 4e-43, Method: Composition-based stats. Identities = 53/138 (38%), Positives = 76/138 (55%) Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136 L AA AG+D+ V+ LL GA VN ++ G TPLH AA + I +LL+ GA+ +A D Sbjct: 18 LLEAARAGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNAND 77 Query: 137 HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGA 196 T +H AA G+L+++ +LL A N D G PLHLA E ++L+ GA Sbjct: 78 ERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGYKEIVEVLLKAGA 137 Query: 197 SIYIENKEEKTPLQVAKG 214 + ++K K PL +A Sbjct: 138 DVDAQDKFGKRPLWLAAD 155 Score = 163 bits (412), Expect = 6e-41, Method: Composition-based stats. Identities = 57/153 (37%), Positives = 85/153 (55%), Gaps = 1/153 (0%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 + A +G+ +E++ +LA+ + D+ T LH A GH IVE LL+ G VN Sbjct: 18 LLEAARAGQDDEVR-ILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNAN 76 Query: 70 DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG 129 D+ G +PLH+AA G EIV+ LL GA VNA + G PLH AA EI +LL+ G Sbjct: 77 DERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGYKEIVEVLLKAG 136 Query: 130 ANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK 162 A+ DA+D + + AA +G+ ++ L+ + Sbjct: 137 ADVDAQDKFGKRPLWLAADQGHAEIAAKLVAAR 169 Score = 82.3 bits (202), Expect = 2e-16, Method: Composition-based stats. Identities = 25/82 (30%), Positives = 38/82 (46%) Query: 143 MHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIEN 202 + AA G + ILL A N D G TPLHLA E + ++L+ GA + + Sbjct: 18 LLEAARAGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNAND 77 Query: 203 KEEKTPLQVAKGGLGLILKRMV 224 + TPL +A L + ++ Sbjct: 78 ERGHTPLHLAAYTGHLEIVEVL 99 >6FES-A nrPDB Length = 367 Score = 181 bits (460), Expect = 2e-46, Method: Composition-based stats. Identities = 59/147 (40%), Positives = 77/147 (52%) Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103 L A AG + V LL G VN D+ G++PLH+AA G IV+ LL GA VNA + Sbjct: 10 LLEAARAGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNAND 69 Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163 + G TPLH AA EI +LL+ GA +A D +H AA G+ +++ +LL A Sbjct: 70 ERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGHEEIVEVLLKNGA 129 Query: 164 STNIQDTEGNTPLHLACDEERVEEAKL 190 QD G TP LA D A+L Sbjct: 130 DARAQDKFGKTPEDLARDNGYESVARL 156 Score = 172 bits (436), Expect = 1e-43, Method: Composition-based stats. Identities = 53/138 (38%), Positives = 76/138 (55%) Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136 L AA AG+D+ V+ LL GA VN ++ G TPLH AA + I +LL+ GA+ +A D Sbjct: 10 LLEAARAGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNAND 69 Query: 137 HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGA 196 T +H AA G+L+++ +LL A N D G PLHLA E ++L+ GA Sbjct: 70 ERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGHEEIVEVLLKNGA 129 Query: 197 SIYIENKEEKTPLQVAKG 214 ++K KTP +A+ Sbjct: 130 DARAQDKFGKTPEDLARD 147 Score = 159 bits (403), Expect = 8e-40, Method: Composition-based stats. Identities = 55/148 (37%), Positives = 78/148 (52%), Gaps = 1/148 (0%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 + A +G+ +E++ +LA+ + D+ T LH A GH IVE LL+ G VN Sbjct: 10 LLEAARAGQDDEVR-ILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNAN 68 Query: 70 DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG 129 D+ G +PLH+AA G EIV+ LL GA VNA + G PLH AA EI +LL+ G Sbjct: 69 DERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGHEEIVEVLLKNG 128 Query: 130 ANPDAKDHYEATAMHRAAAKGNLKMIHI 157 A+ A+D + T A G + + Sbjct: 129 ADARAQDKFGKTPEDLARDNGYESVARL 156 Score = 83.5 bits (205), Expect = 8e-17, Method: Composition-based stats. Identities = 25/82 (30%), Positives = 38/82 (46%) Query: 143 MHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIEN 202 + AA G + ILL A N D G TPLHLA E + ++L+ GA + + Sbjct: 10 LLEAARAGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNAND 69 Query: 203 KEEKTPLQVAKGGLGLILKRMV 224 + TPL +A L + ++ Sbjct: 70 ERGHTPLHLAAYTGHLEIVEVL 91 >1WG0-A nrPDB Length = 243 Score = 179 bits (455), Expect = 7e-46, Method: Composition-based stats. Identities = 75/215 (34%), Positives = 108/215 (50%), Gaps = 7/215 (3%) Query: 5 VSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGV 64 +SN + + +++E + + SL + DQD R LHW+ S EI FLL Sbjct: 1 MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME 60 Query: 65 PVND---KDDAGWSPLHIAASAGRDEIVKALLGKG--AQVNAVNQNGCTPLHYAASKNRH 119 VN DD+GW+P HIA S G E+VK+L + +N + G T LH A K Sbjct: 61 NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWF 120 Query: 120 EIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAS-TNIQDTEGNTPLHL 178 E++ L+E GA+ KD + +HRAA+ G+LK+I +L S N QD +G TPL Sbjct: 121 EVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFH 180 Query: 179 ACDEERVEEAKLLVSQ-GASIYIENKEEKTPLQVA 212 A E + A LLV + GA + + + VA Sbjct: 181 ALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVA 215 Score = 103 bits (258), Expect = 4e-23, Method: Composition-based stats. Identities = 49/157 (31%), Positives = 74/157 (47%), Gaps = 6/157 (3%) Query: 76 PLHIAASAGRDEIVKALL-GKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134 PLH A V+ LL K + + +Q+G PLH++ S HEI LL N + Sbjct: 5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNL 64 Query: 135 KDH---YEATAMHRAAAKGNLKMIHILL--YYKASTNIQDTEGNTPLHLACDEERVEEAK 189 D+ T H A + GNL+++ L K N +G T LHLA ++ E ++ Sbjct: 65 DDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWFEVSQ 124 Query: 190 LLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG 226 L+ GAS+ I++K + PL A L L ++ G Sbjct: 125 FLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCG 161 >5H76-A nrPDB Length = 201 Score = 170 bits (430), Expect = 5e-43, Method: Composition-based stats. Identities = 55/149 (36%), Positives = 84/149 (56%), Gaps = 1/149 (0%) Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136 L AA AG+D+ V+ L+ GA VNA + G TPLH AA EI +LL+ GA+ DA D Sbjct: 10 LLEAARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASD 69 Query: 137 HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGA 196 + T +H AA G+L+++ +LL A N D++G TPLHLA +E ++L+ GA Sbjct: 70 VFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEIVEVLLKHGA 129 Query: 197 SIYIENKEEKTPLQVAKGGLGLILKRMVE 225 + ++K KT ++ L +++ Sbjct: 130 -VNAQDKFGKTAFDISIDNGNEDLAQILA 157 Score = 165 bits (419), Expect = 1e-41, Method: Composition-based stats. Identities = 58/148 (39%), Positives = 82/148 (55%), Gaps = 1/148 (0%) Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103 L A AG + V L+ G VN D+ G +PLH+AA +G EIV+ LL GA V+A + Sbjct: 10 LLEAARAGQDDEVRILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDASD 69 Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163 G TPLH AA EI +LL+ GA+ +A D T +H AA G L+++ +LL + A Sbjct: 70 VFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEIVEVLLKHGA 129 Query: 164 STNIQDTEGNTPLHLACDEERVEEAKLL 191 N QD G T ++ D + A++L Sbjct: 130 -VNAQDKFGKTAFDISIDNGNEDLAQIL 156 Score = 162 bits (411), Expect = 8e-41, Method: Composition-based stats. Identities = 59/154 (38%), Positives = 88/154 (57%), Gaps = 2/154 (1%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 + A +G+ +E++ ++A+ + D T LH A +GH EIVE LL+ G V+ Sbjct: 10 LLEAARAGQDDEVR-ILMANGADVNAADNTGTTPLHLAAYSGHLEIVEVLLKHGADVDAS 68 Query: 70 DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG 129 D G++PLH+AA G EIV+ LL GA VNA++ +G TPLH AA EI +LL+ G Sbjct: 69 DVFGYTPLHLAAYWGHLEIVEVLLKNGADVNAMDSDGMTPLHLAAKWGYLEIVEVLLKHG 128 Query: 130 ANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163 A +A+D + TA + GN + IL +Y+ Sbjct: 129 A-VNAQDKFGKTAFDISIDNGNEDLAQILAFYEI 161 >5HKP-A nrPDB Length = 351 Score = 169 bits (427), Expect = 1e-42, Method: Composition-based stats. Identities = 72/239 (30%), Positives = 107/239 (44%), Gaps = 24/239 (10%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 + A SG E+L + +D T LH A IV+ LLQ G V+ K Sbjct: 28 LLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK 87 Query: 70 DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG 129 D G PLH A S G E+ + LL GA VNA++ TPLH AASKNR E+ +LL G Sbjct: 88 DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHG 147 Query: 130 ANPDAKD---------------------HYEATAMHRAAAKGNLKMIHILLYYKASTNIQ 168 A+P + ++ ++ +AA + +L + L + Q Sbjct: 148 ADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQ 207 Query: 169 DTEGNTPLHLA---CDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMV 224 T LH A +R + A+LL+ +GA++ +NK+ TPL VA + ++ Sbjct: 208 PQSHETALHCAVASLHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL 266 Score = 118 bits (296), Expect = 2e-27, Method: Composition-based stats. Identities = 57/240 (23%), Positives = 88/240 (36%), Gaps = 25/240 (10%) Query: 7 NLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPV 66 + + N G E+ E +L + D T LH A S E+ LL G Sbjct: 92 LVPLHNACSYGHY-EVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADP 150 Query: 67 NDKDDAGWSP---------------------LHIAASAGRDEIVKALLGKGAQVNAVNQN 105 + G S L AA VK L Q+ Sbjct: 151 TLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQS 210 Query: 106 GCTPLHYAASKNRHE---IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK 162 T LH A + + +A +LL GAN + K+ T +H AA + + ++ +L + Sbjct: 211 HETALHCAVASLHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG 270 Query: 163 ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKR 222 A N D+ G T LH A ++ +LL+S G+ I + + T Q+ + IL Sbjct: 271 AKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSE 330 Score = 76.2 bits (186), Expect = 1e-14, Method: Composition-based stats. Identities = 25/89 (28%), Positives = 41/89 (46%), Gaps = 1/89 (1%) Query: 125 LLEGGANPDAKDHYEATAMHRAAAKGNLK-MIHILLYYKASTNIQDTEGNTPLHLACDEE 183 L + A Y+ + AA GN + ++ +L + + D +TPLHLA Sbjct: 10 LADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYN 69 Query: 184 RVEEAKLLVSQGASIYIENKEEKTPLQVA 212 RV +LL+ GA ++ ++K PL A Sbjct: 70 RVRIVQLLLQHGADVHAKDKGGLVPLHNA 98 >3ZKJ-A nrPDB Length = 261 Score = 163 bits (413), Expect = 5e-41, Method: Composition-based stats. Identities = 52/172 (30%), Positives = 84/172 (48%), Gaps = 2/172 (1%) Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98 + +H A GH + L+ G VN SPLH A G VK LL GAQ Sbjct: 2 SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQ 61 Query: 99 VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158 VN V + TPL A + +LL+ GA+ + A+ +H AA +G+++ ++ L Sbjct: 62 VNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDL-ASPIHEAARRGHVECVNSL 120 Query: 159 LYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQ 210 + Y + + + + TPL+LAC+ ++ K L+ GA + + K + +PL Sbjct: 121 IAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLH 171 Score = 136 bits (343), Expect = 7e-33, Method: Composition-based stats. Identities = 56/203 (27%), Positives = 84/203 (41%), Gaps = 3/203 (1%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVND 68 + A G L+ ++++ D + LH AC GH V+ LL+ G VN Sbjct: 6 PMHEAAIHGHQLSLR-NLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 64 Query: 69 KDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG 128 +PL A +G + V LL GA V + +P+H AA + E L+ Sbjct: 65 VTADWHTPLFNACVSGSWDCVNLLLQHGASV-QPESDLASPIHEAARRGHVECVNSLIAY 123 Query: 129 GANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEA 188 G N D K + T ++ A + LL A N Q ++PLH E A Sbjct: 124 GGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN-QGKGQDSPLHAVARTASEELA 182 Query: 189 KLLVSQGASIYIENKEEKTPLQV 211 LL+ GA +N E K P+++ Sbjct: 183 CLLMDFGADTQAKNAEGKRPVEL 205 Score = 109 bits (273), Expect = 9e-25, Method: Composition-based stats. Identities = 40/153 (26%), Positives = 72/153 (47%), Gaps = 2/153 (1%) Query: 74 WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133 WSP+H AA G ++ L+ +G VN + + +PLH A +LL+ GA + Sbjct: 4 WSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVN 63 Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVS 193 T + A G+ +++LL + AS +++ +P+H A VE L++ Sbjct: 64 GVTADWHTPLFNACVSGSWDCVNLLLQHGASVQ-PESDLASPIHEAARRGHVECVNSLIA 122 Query: 194 QGASIYIENKEEKTPLQVA-KGGLGLILKRMVE 225 G +I + TPL +A + +K+++E Sbjct: 123 YGGNIDHKISHLGTPLYLACENQQRACVKKLLE 155 >4O1O-A nrPDB Length = 717 Score = 161 bits (408), Expect = 2e-40, Method: Composition-based stats. Identities = 57/231 (24%), Positives = 95/231 (41%), Gaps = 15/231 (6%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVND 68 M+ +E++++ + + ++ + LH A ++V LL+ G Sbjct: 11 MLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCL 70 Query: 69 KDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG 128 + G +P IA G +++ LL VN + NG T AA R E L E Sbjct: 71 RKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYEN 130 Query: 129 GANPDAKDHY----------EATAMHRAAAKGNLKMIHILL-YYKASTNIQDTEGNTPLH 177 GA+ + ATA+ AA KG++ ++ ILL KA + +D G L Sbjct: 131 GADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALV 190 Query: 178 LACDE----ERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMV 224 A + +LL+ GA + + + KTPL +A L L +M+ Sbjct: 191 YALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQML 241 Score = 127 bits (318), Expect = 6e-30, Method: Composition-based stats. Identities = 55/197 (27%), Positives = 80/197 (40%), Gaps = 16/197 (8%) Query: 22 LKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVND----------KDD 71 L + +L + D + TA A G E + FL + G VN Sbjct: 90 LLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRK 149 Query: 72 AGWSPLHIAASAGRDEIVKALL-GKGAQVNAVNQNGCTPLHYAASKNR----HEIAVMLL 126 G + L AA G +V LL A+V+A + G L YA I +LL Sbjct: 150 GGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLL 209 Query: 127 EGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK-ASTNIQDTEGNTPLHLACDEERV 185 + GA+ + + T + A + NL ++ +LL + N D EG T L LA + Sbjct: 210 DHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAVELRLE 269 Query: 186 EEAKLLVSQGASIYIEN 202 E AKLL +GAS + Sbjct: 270 EIAKLLCHRGASTNCGD 286 >5ET1-A nrPDB Length = 353 Score = 159 bits (403), Expect = 8e-40, Method: Composition-based stats. Identities = 62/209 (29%), Positives = 96/209 (45%), Gaps = 5/209 (2%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGV-PVND 68 A G L+ L+ A + D +H A +G + +L++ P Sbjct: 7 ALQAARRGDLDVLRSLHAAGLLGPSLRDSLDALPVHHAARSGKLHCLRYLVEEVALPAVS 66 Query: 69 KDDAGWSPLHIAASAGRDEIVKALLGK-GAQVNAVNQNGCTPLHYAASKNRHEIAVMLL- 126 + G +P H AA+ G ++ LL + G +V + +G T LH AA ++ LL Sbjct: 67 RARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDNSGATVLHLAARFGHPDVVKWLLY 126 Query: 127 EGGANPDAKDHYEATAMHRAAAKGNLKMIHILL-YYKASTNIQDTEGNTPLHLACDEERV 185 +GGAN A +H AAAKG+L + +L+ +Y N Q G TPL+LAC E + Sbjct: 127 QGGANSAITTDTGALPIHYAAAKGDLPSLKLLVGHYPEGVNAQTNNGATPLYLACQEGHL 186 Query: 186 EEAKLLVSQ-GASIYIENKEEKTPLQVAK 213 E K LV + A ++ ++ TPL A Sbjct: 187 EVTKYLVQECSADPHLRAQDGMTPLHAAA 215 Score = 133 bits (336), Expect = 5e-32, Method: Composition-based stats. Identities = 57/208 (27%), Positives = 102/208 (49%), Gaps = 4/208 (1%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQL-GVPVN 67 ++ A G + +K + + + T +H+A + G ++ L+ VN Sbjct: 108 VLHLAARFGHPDVVKWLLYQGGANSAITTDTGALPIHYAAAKGDLPSLKLLVGHYPEGVN 167 Query: 68 DKDDAGWSPLHIAASAGRDEIVKALLGK-GAQVNAVNQNGCTPLHYAASKNRHEIAVMLL 126 + + G +PL++A G E+ K L+ + A + Q+G TPLH AA + + V L+ Sbjct: 168 AQTNNGATPLYLACQEGHLEVTKYLVQECSADPHLRAQDGMTPLHAAAQMGHNPVLVWLV 227 Query: 127 EGG-ANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV 185 + +DH ATAMH AA++G+ K++ LL + A + QD G TPLH A + + Sbjct: 228 SFADVSFSEQDHDGATAMHFAASRGHTKVLSWLLLHGAEIS-QDLWGGTPLHDAAENGEL 286 Query: 186 EEAKLLVSQGASIYIENKEEKTPLQVAK 213 E ++L GA + + + + T +A+ Sbjct: 287 ECCQILAVNGAGLDVRDHDGYTAADLAE 314 Score = 130 bits (326), Expect = 6e-31, Method: Composition-based stats. Identities = 48/186 (25%), Positives = 82/186 (44%), Gaps = 3/186 (1%) Query: 8 LMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL-QLGVPV 66 L + A G L LK + + T L+ AC GH E+ ++L+ + Sbjct: 141 LPIHYAAAKGDLPSLKLLVGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQECSADP 200 Query: 67 NDKDDAGWSPLHIAASAGRDEIVKALLG-KGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125 + + G +PLH AA G + ++ L+ + + +G T +H+AAS+ ++ L Sbjct: 201 HLRAQDGMTPLHAAAQMGHNPVLVWLVSFADVSFSEQDHDGATAMHFAASRGHTKVLSWL 260 Query: 126 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV 185 L GA +D + T +H AA G L+ IL A +++D +G T LA Sbjct: 261 LLHGAEIS-QDLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLAEFNGHT 319 Query: 186 EEAKLL 191 ++ L Sbjct: 320 HCSRYL 325 Score = 124 bits (311), Expect = 3e-29, Method: Composition-based stats. Identities = 67/257 (26%), Positives = 107/257 (41%), Gaps = 41/257 (15%) Query: 8 LMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL-QLGVPV 66 L V + A SGKL L+ + A ++ T H A + G+ +++LL Q G V Sbjct: 39 LPVHHAARSGKLHCLRYLVEEVALPAVSRARNGATPAHDAAATGYLSCLQWLLTQGGCRV 98 Query: 67 NDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ---------------------------- 98 +KD++G + LH+AA G ++VK LL +G Sbjct: 99 QEKDNSGATVLHLAARFGHPDVVKWLLYQGGANSAITTDTGALPIHYAAAKGDLPSLKLL 158 Query: 99 -------VNAVNQNGCTPLHYAASKNRHEIAVMLL-EGGANPDAKDHYEATAMHRAAAKG 150 VNA NG TPL+ A + E+ L+ E A+P + T +H AA G Sbjct: 159 VGHYPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQECSADPHLRAQDGMTPLHAAAQMG 218 Query: 151 NLKMIHILLYYKAST--NIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTP 208 + ++ L+ + A + QD +G T +H A + L+ GA I ++ TP Sbjct: 219 HNPVLVWLVSF-ADVSFSEQDHDGATAMHFAASRGHTKVLSWLLLHGAEI-SQDLWGGTP 276 Query: 209 LQVAKGGLGLILKRMVE 225 L A L +++ Sbjct: 277 LHDAAENGELECCQILA 293 >3EU9-A nrPDB Length = 240 Score = 157 bits (396), Expect = 5e-39, Method: Composition-based stats. Identities = 55/188 (29%), Positives = 90/188 (47%), Gaps = 2/188 (1%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVND 68 ++ A + +++ +K I + + T LHWA GH +V L++ G + Sbjct: 45 LLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSL 104 Query: 69 KDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNR-HEIAVMLLE 127 D G S +H+AA G IV L+ KG V+ ++QNG TPL +AA + + +LL Sbjct: 105 IDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLT 164 Query: 128 GGANPDAKDHY-EATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVE 186 + + D Y + TA+H A GN +I +LL A+ + Q+ +G + L LA + V Sbjct: 165 FNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVW 224 Query: 187 EAKLLVSQ 194 L Sbjct: 225 MINHLQEA 232 Score = 151 bits (381), Expect = 2e-37, Method: Composition-based stats. Identities = 50/191 (26%), Positives = 87/191 (45%), Gaps = 3/191 (1%) Query: 26 ILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKD-DAGWSPLHIAASAG 84 ++ + D+++ T LHWA ++V++ + G V+ D +PLH A G Sbjct: 28 LVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQG 87 Query: 85 RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144 +V L+ GA + ++ GC+ +H AA I L+ G + D D T + Sbjct: 88 HLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLM 147 Query: 145 RAAAKGN-LKMIHILLYYKASTNIQDTEG-NTPLHLACDEERVEEAKLLVSQGASIYIEN 202 AA + + + +LL + S N+ D NT LH A LL+ GA++ +N Sbjct: 148 WAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQN 207 Query: 203 KEEKTPLQVAK 213 + ++ L +AK Sbjct: 208 IKGESALDLAK 218 Score = 106 bits (264), Expect = 1e-23, Method: Composition-based stats. Identities = 37/135 (27%), Positives = 62/135 (45%), Gaps = 1/135 (0%) Query: 80 AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD-AKDHY 138 A G E + L+ G V ++ T LH+AA NR ++ + GA D Sbjct: 16 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDL 75 Query: 139 EATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASI 198 +T +H A +G+L M+ L+ Y A ++ D EG + +HLA L+++G + Sbjct: 76 NSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDV 135 Query: 199 YIENKEEKTPLQVAK 213 + ++ TPL A Sbjct: 136 DMMDQNGMTPLMWAA 150 Score = 77.3 bits (189), Expect = 5e-15, Method: Composition-based stats. Identities = 34/129 (26%), Positives = 49/129 (37%), Gaps = 6/129 (4%) Query: 2 EGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGH-TEIVEFLL 60 EGC + ++ + ++A DQ+ T L WA H + LL Sbjct: 108 EGCSCIHLAAQFGHT----SIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLL 163 Query: 61 QLGVPVNDKDDAG-WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRH 119 V VN D + LH A AG ++ LL GA V+A N G + L A + Sbjct: 164 TFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNV 223 Query: 120 EIAVMLLEG 128 + L E Sbjct: 224 WMINHLQEA 232 Score = 28.0 bits (61), Expect = 3.7, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 16/44 (36%) Query: 179 ACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKR 222 A E + LV G + +KE T L A + L + Sbjct: 16 ATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVK 59 >4OT9-A nrPDB Length = 359 Score = 152 bits (385), Expect = 8e-38, Method: Composition-based stats. Identities = 65/218 (29%), Positives = 101/218 (46%), Gaps = 11/218 (5%) Query: 3 GCVSNLMVCNLAYSGKLEELKESIL--ADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60 G + + +E++ I D + T+ +T LH A G T +V FLL Sbjct: 82 GDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQTSVVSFLL 141 Query: 61 QLGVPVNDKDDAGWSPLHIA--ASAGRDEIVKALLGKGAQ-----VNAVNQNGCTPLHYA 113 ++G D G S +H+A A AG E+++ALL GA ++ + G P+H A Sbjct: 142 RVGADPALLDRHGDSAMHLALRAGAGAPELLRALLQSGAPAVPQLLHMPDFEGLYPVHLA 201 Query: 114 ASKNRHEIAVMLLEGGANPDAKDHYEA-TAMHRAAAKGNLKMIHILL-YYKASTNIQDTE 171 E +L++ GA +A + TA+H A L ++ L+ +A+ N + Sbjct: 202 VRARSPECLDLLVDSGAEVEATERQGGRTALHLATEMEELGLVTHLVTKLRANVNARTFA 261 Query: 172 GNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPL 209 GNTPLHLA +LL+ GA I+ EN+E PL Sbjct: 262 GNTPLHLAAGLGYPTLTRLLLKAGADIHAENEEPLCPL 299 Score = 55.8 bits (133), Expect = 2e-08, Method: Composition-based stats. Identities = 18/87 (20%), Positives = 35/87 (40%), Gaps = 6/87 (6%) Query: 132 PDAKDHYEATAMHRAAAKGNLKMIH---ILLYYKAS---TNIQDTEGNTPLHLACDEERV 185 A+D T +H A G +I ++++ N+ + TPLHLA + Sbjct: 75 LTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQDLGVVNLTNHLHQTPLHLAVITGQT 134 Query: 186 EEAKLLVSQGASIYIENKEEKTPLQVA 212 L+ GA + ++ + + +A Sbjct: 135 SVVSFLLRVGADPALLDRHGDSAMHLA 161 >5CBO-A nrPDB Length = 176 Score = 143 bits (362), Expect = 4e-35, Method: Composition-based stats. Identities = 47/120 (39%), Positives = 66/120 (55%) Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136 L AA AG+D+ V+ L+ GA VNA++ G TPLH AA EI +LL+ GA+ +A D Sbjct: 7 LLEAAHAGQDDEVRILMANGADVNAMDNFGVTPLHLAAYWGHFEIVEVLLKYGADVNASD 66 Query: 137 HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGA 196 T +H AA G L ++ +LL Y A N QD G T ++ D + A++L A Sbjct: 67 ATGDTPLHLAAKWGYLGIVEVLLKYGADVNAQDKFGKTAFDISIDNGNEDLAEILCKNKA 126 Score = 135 bits (341), Expect = 1e-32, Method: Composition-based stats. Identities = 49/120 (40%), Positives = 64/120 (53%) Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103 L A AG + V L+ G VN D+ G +PLH+AA G EIV+ LL GA VNA + Sbjct: 7 LLEAAHAGQDDEVRILMANGADVNAMDNFGVTPLHLAAYWGHFEIVEVLLKYGADVNASD 66 Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163 G TPLH AA I +LL+ GA+ +A+D + TA + GN + IL KA Sbjct: 67 ATGDTPLHLAAKWGYLGIVEVLLKYGADVNAQDKFGKTAFDISIDNGNEDLAEILCKNKA 126 Score = 126 bits (317), Expect = 7e-30, Method: Composition-based stats. Identities = 33/115 (28%), Positives = 59/115 (51%) Query: 110 LHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQD 169 L AA + + +L+ GA+ +A D++ T +H AA G+ +++ +LL Y A N D Sbjct: 7 LLEAAHAGQDDEVRILMANGADVNAMDNFGVTPLHLAAYWGHFEIVEVLLKYGADVNASD 66 Query: 170 TEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMV 224 G+TPLHLA + ++L+ GA + ++K KT ++ L ++ Sbjct: 67 ATGDTPLHLAAKWGYLGIVEVLLKYGADVNAQDKFGKTAFDISIDNGNEDLAEIL 121 Score = 123 bits (310), Expect = 5e-29, Method: Composition-based stats. Identities = 42/121 (34%), Positives = 64/121 (52%), Gaps = 1/121 (0%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 + A++G+ +E++ ++A+ + D T LH A GH EIVE LL+ G VN Sbjct: 7 LLEAAHAGQDDEVR-ILMANGADVNAMDNFGVTPLHLAAYWGHFEIVEVLLKYGADVNAS 65 Query: 70 DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG 129 D G +PLH+AA G IV+ LL GA VNA ++ G T + ++A +L + Sbjct: 66 DATGDTPLHLAAKWGYLGIVEVLLKYGADVNAQDKFGKTAFDISIDNGNEDLAEILCKNK 125 Query: 130 A 130 A Sbjct: 126 A 126 >4Z68-A nrPDB Length = 155 Score = 143 bits (361), Expect = 6e-35, Method: Composition-based stats. Identities = 54/150 (36%), Positives = 80/150 (53%), Gaps = 4/150 (2%) Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGW--SPLHIAASAGRDEIVKALLGKGAQVNA 101 L A AG E V+ L VN +D G +PLH AA R +V+ LL GA V+A Sbjct: 7 LLEAAKAGDVETVKKLC-TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA 65 Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161 ++ G PLH A S +E+A +L++ GA + D ++ T +H AAAKG ++ +LL + Sbjct: 66 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQH 125 Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLL 191 A ++ +GNTPL L + + LL Sbjct: 126 GADPTKKNRDGNTPLDL-VKDGDTDIQDLL 154 Score = 140 bits (354), Expect = 3e-34, Method: Composition-based stats. Identities = 48/149 (32%), Positives = 73/149 (48%), Gaps = 1/149 (0%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 + A +G +E +K+ + T LH+A +VE+LLQ G V+ K Sbjct: 7 LLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAK 66 Query: 70 DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG 129 D G PLH A S G E+ + L+ GA VN + TPLH AA+K ++EI +LL+ G Sbjct: 67 DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG 126 Query: 130 ANPDAKDHYEATAMHRAAAKGNLKMIHIL 158 A+P K+ T + G+ + +L Sbjct: 127 ADPTKKNRDGNTPLDL-VKDGDTDIQDLL 154 Score = 131 bits (329), Expect = 3e-31, Method: Composition-based stats. Identities = 51/141 (36%), Positives = 72/141 (51%), Gaps = 3/141 (2%) Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGC--TPLHYAASKNRHEIAVMLLEGGANPDA 134 L AA AG E VK L VN + G TPLH+AA NR + LL+ GA+ A Sbjct: 7 LLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA 65 Query: 135 KDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQ 194 KD +H A + G+ ++ +L+ + A N+ D TPLH A + + E KLL+ Sbjct: 66 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQH 125 Query: 195 GASIYIENKEEKTPLQVAKGG 215 GA +N++ TPL + K G Sbjct: 126 GADPTKKNRDGNTPLDLVKDG 146 >5GP7-A nrPDB Length = 169 Score = 134 bits (337), Expect = 3e-32, Method: Composition-based stats. Identities = 50/147 (34%), Positives = 75/147 (51%), Gaps = 3/147 (2%) Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGW--SPLHIAASAGRDEIVKALLGKG 96 AL A G V+ L +N +D G +PLH+AA E+ + LL G Sbjct: 8 RGDAALLDAAKKGCLARVQKLC-TPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHG 66 Query: 97 AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156 A VNA ++ G PLH AAS +IA +L++ +A D + T +H AA KG ++ Sbjct: 67 ADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCA 126 Query: 157 ILLYYKASTNIQDTEGNTPLHLACDEE 183 +LL + A +++ EG TPL LA ++ Sbjct: 127 LLLAHGADPTMKNQEGQTPLDLATADD 153 Score = 127 bits (318), Expect = 6e-30, Method: Composition-based stats. Identities = 49/142 (34%), Positives = 73/142 (51%), Gaps = 3/142 (2%) Query: 73 GWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGC--TPLHYAASKNRHEIAVMLLEGGA 130 G + L AA G V+ L +N + G TPLH AA N E+A LLE GA Sbjct: 9 GDAALLDAAKKGCLARVQKL-CTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGA 67 Query: 131 NPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKL 190 + +A+D +H AA+ G++ + +L+ Y N D TPLH A + R + L Sbjct: 68 DVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCAL 127 Query: 191 LVSQGASIYIENKEEKTPLQVA 212 L++ GA ++N+E +TPL +A Sbjct: 128 LLAHGADPTMKNQEGQTPLDLA 149 Score = 125 bits (315), Expect = 1e-29, Method: Composition-based stats. Identities = 46/139 (33%), Positives = 68/139 (48%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 + + A G L +++ + T + T LH A + E+ E+LL+ G VN + Sbjct: 13 LLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQ 72 Query: 70 DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG 129 D G PLH AAS G +I L+ VNA ++ TPLH AA K R ++ +LL G Sbjct: 73 DKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHG 132 Query: 130 ANPDAKDHYEATAMHRAAA 148 A+P K+ T + A A Sbjct: 133 ADPTMKNQEGQTPLDLATA 151 >6EMK-G nrPDB Length = 426 Score = 131 bits (329), Expect = 3e-31, Method: Composition-based stats. Identities = 43/140 (30%), Positives = 69/140 (49%), Gaps = 5/140 (3%) Query: 77 LHIAASAGRDEIVKALLGKGAQV--NAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD- 133 L A G IVK LL + + N ++NG + LHYA+ R+ I V L++ G + Sbjct: 9 LREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHDKHE 68 Query: 134 -AKDHYEATAMHRAAAKGNLKMIHILLY-YKASTNIQDTEGNTPLHLACDEERVEEAKLL 191 K T +H A KG+ + +H+LL + N + G P+H+AC + + LL Sbjct: 69 LIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQCLSLL 128 Query: 192 VSQGASIYIENKEEKTPLQV 211 + GA +++ + TPL V Sbjct: 129 IGVGADLWVMDTNGDTPLHV 148 Score = 108 bits (271), Expect = 1e-24, Method: Composition-based stats. Identities = 44/178 (24%), Positives = 76/178 (42%), Gaps = 8/178 (4%) Query: 44 LHWACSAGHTEIVEFLLQLGVPV--NDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101 L A G+ IV+ LL+ + N + GWS LH A+ GR I L+ G + Sbjct: 9 LREAIIEGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHDKHE 68 Query: 102 --VNQNGCTPLHYAASKNRHEIAVMLLEGGAN-PDAKDHYEATAMHRAAAKGNLKMIHIL 158 G T +H A K + +LL+ + + +H A + + +L Sbjct: 69 LIKTFKGNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQCLSLL 128 Query: 159 LYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGA---SIYIENKEEKTPLQVAK 213 + A + DT G+TPLH+ + + K+L+++G + +K P+ VA+ Sbjct: 129 IGVGADLWVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVSLDDNVRDKGNWKPIDVAQ 186 Score = 105 bits (261), Expect = 2e-23, Method: Composition-based stats. Identities = 41/171 (23%), Positives = 79/171 (46%), Gaps = 7/171 (4%) Query: 16 SGKLEELKESILADKSLATRTD-QDSRTALHWACSAGHTEIVEFLLQLGVPVND--KDDA 72 G L +K + + L T D ++ ++LH+A G I +L+QLG ++ K Sbjct: 15 EGNLLIVKRLLRRNPDLLTNIDSENGWSSLHYASYHGRYLICVYLIQLGHDKHELIKTFK 74 Query: 73 GWSPLHIAASAGRDEIVKALLGKGAQ-VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131 G + +H+A G ++ + LL + + +N +NG P+H A + ++ +L+ GA+ Sbjct: 75 GNTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQCLSLLIGVGAD 134 Query: 132 PDAKDHYEATAMHRAAAKGNLKMIHILLYYKA---STNIQDTEGNTPLHLA 179 D T +H G++ + +LL N++D P+ +A Sbjct: 135 LWVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVSLDDNVRDKGNWKPIDVA 185 Score = 67.7 bits (164), Expect = 4e-12, Method: Composition-based stats. Identities = 23/110 (20%), Positives = 41/110 (37%), Gaps = 3/110 (2%) Query: 7 NLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPV 66 N V G + L + ++ R +H AC + + + L+ +G + Sbjct: 76 NTCVHLALMKGHEQTLHLLLQQFPRFINHRGENGRAPIHIACMNDYYQCLSLLIGVGADL 135 Query: 67 NDKDDAGWSPLHIAASAGRDEIVKALLGKG---AQVNAVNQNGCTPLHYA 113 D G +PLH+ G +K LL +G N ++ P+ A Sbjct: 136 WVMDTNGDTPLHVCLEYGSISCMKMLLNEGEVSLDDNVRDKGNWKPIDVA 185 >3LJN-A nrPDB Length = 364 Score = 126 bits (316), Expect = 1e-29, Method: Composition-based stats. Identities = 49/187 (26%), Positives = 86/187 (45%), Gaps = 30/187 (16%) Query: 35 RTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLG 94 ++D ++ +H A G T+ V L++ GV ++ G + LH+A G + K L Sbjct: 15 KSDDENMEKIHVAARKGQTDEVRRLIETGVSPTIQNRFGCTALHLACKFGCVDTAKYLAS 74 Query: 95 KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKM 154 G +V+++ +G P+H A N+ ++ V L+EG AK +M Sbjct: 75 VG-EVHSL-WHGQKPIHLAVMANKTDLVVALVEG-------------------AKERGQM 113 Query: 155 IHILLY-------YKASTNIQDTEGNTPLH--LACDEERVEEAKLLVSQGASIYIENKEE 205 LL + ++++ +G T LH + E +E K+LV GAS ++K + Sbjct: 114 PESLLNECDEREVNEIGSHVKHCKGQTALHWCVGLGPEYLEMIKILVQLGASPTAKDKAD 173 Query: 206 KTPLQVA 212 +TPL A Sbjct: 174 ETPLMRA 180 Score = 69.6 bits (169), Expect = 9e-13, Method: Composition-based stats. Identities = 41/177 (23%), Positives = 73/177 (41%), Gaps = 22/177 (12%) Query: 39 DSRTALHWACSAG--HTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL--- 93 +TALHW G + E+++ L+QLG KD A +PL A E + ++ Sbjct: 137 KGQTALHWCVGLGPEYLEMIKILVQLGASPTAKDKADETPLMRAMEFRNREALDLMMDTV 196 Query: 94 --GKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN 151 +++ N+ G + LH+A N ++A+ +E G + + +D+ ++ + Sbjct: 197 PSKSSLRLDYANKQGNSHLHWAILINWEDVAMRFVEMGIDVNMEDNEHTVPLYLSVRAAM 256 Query: 152 LKMIHILLYYKASTN-IQDT---EGNTPLHL----------ACDEERVEEAKLLVSQ 194 + + LL K IQ G T L A D + E +LL + Sbjct: 257 VLLTKELLQ-KTDVFLIQACPYHNGTTVLPDRVVWLDFVPAAADPSKQEVLQLLQEK 312 Score = 35.0 bits (79), Expect = 0.031, Method: Composition-based stats. Identities = 15/60 (25%), Positives = 30/60 (50%) Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95 ++ + LHWA ++ +++G+ VN +D+ PL+++ A + K LL K Sbjct: 207 ANKQGNSHLHWAILINWEDVAMRFVEMGIDVNMEDNEHTVPLYLSVRAAMVLLTKELLQK 266 >6BOA-A nrPDB Length = 742 Score = 120 bits (300), Expect = 6e-28, Method: Composition-based stats. Identities = 42/156 (26%), Positives = 65/156 (41%), Gaps = 19/156 (12%) Query: 75 SPLHIAASAGRDEIVKALLG-KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN-- 131 SPL +AA + + LL + +V+ G T LH AA + E A++L+E Sbjct: 47 SPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELV 106 Query: 132 --PDAKDHY-EATAMHRAAAKGNLKMIHILLYYKASTNIQDT-------------EGNTP 175 P + Y TA+H A N+ ++ LL +AS + + T G P Sbjct: 107 FEPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHP 166 Query: 176 LHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV 211 L A E +LL+ GA I ++ T L + Sbjct: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 Score = 104 bits (259), Expect = 3e-23, Method: Composition-based stats. Identities = 40/201 (19%), Positives = 74/201 (36%), Gaps = 30/201 (14%) Query: 42 TALHWACSAGHTEIVEFLLQLG-VPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQV- 99 + L A + + LL+ V+ + G + LHIAA E L+ ++ Sbjct: 47 SPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELV 106 Query: 100 ----NAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD-------------HYEATA 142 + G T LH A + LL A+ A+ ++ Sbjct: 107 FEPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHP 166 Query: 143 MHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV----EEAKLLV---SQG 195 + AA + +++ +L+ + A QD+ GNT LH+ + + LL+ G Sbjct: 167 LSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHG 226 Query: 196 ASIY----IENKEEKTPLQVA 212 + + N + TP ++A Sbjct: 227 DHLQPLDLVPNHQGLTPFKLA 247 Score = 98.5 bits (244), Expect = 2e-21, Method: Composition-based stats. Identities = 44/198 (22%), Positives = 66/198 (33%), Gaps = 30/198 (15%) Query: 3 GCVSNLMVCNLAYSGKLEELKESILADKSLA----TRTDQDSRTALHWACSAGHTEIVEF 58 G + + A LE + A L T + +TALH A + +V Sbjct: 76 GAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVVNQNMNLVRA 135 Query: 59 LLQLGVPVNDKDDA-------------GWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN 105 LL V+ + G PL AA +EIV+ L+ GA + A + Sbjct: 136 LLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSL 195 Query: 106 GCTPLHYAASKNRHEIAVMLLEGGANPD-----------AKDHYEATAMHRAAAKGNLKM 154 G T LH + A + + D +H T A +GN M Sbjct: 196 GNTVLHILILQPNKTFACQMYNLLLSYDRHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVM 255 Query: 155 IHILLYYKASTNIQDTEG 172 L+ + + Q T G Sbjct: 256 FQHLMQKR--KHTQWTYG 271 Score = 97.0 bits (240), Expect = 5e-21, Method: Composition-based stats. Identities = 49/217 (22%), Positives = 83/217 (38%), Gaps = 33/217 (15%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVND 68 + A ++ L + + + + TALH A + E L++ + Sbjct: 48 PLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVF 107 Query: 69 KDD-----AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN-------------GCTPL 110 + G + LHIA +V+ALL + A V+A G PL Sbjct: 108 EPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPL 167 Query: 111 HYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNL----KMIHILLYYKASTN 166 +AA N EI +L+E GA+ A+D T +H + N +M ++LL Y + Sbjct: 168 SFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSY--DRH 225 Query: 167 ---------IQDTEGNTPLHLACDEERVEEAKLLVSQ 194 + + +G TP LA E + L+ + Sbjct: 226 GDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 Score = 33.8 bits (76), Expect = 0.062, Method: Composition-based stats. Identities = 9/42 (21%), Positives = 18/42 (42%), Gaps = 1/42 (2%) Query: 173 NTPLHLACDEERVEEAKLLVS-QGASIYIENKEEKTPLQVAK 213 +PL LA + V+ L+ + ++ +T L +A Sbjct: 46 ESPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAA 87 >5D68-A nrPDB Length = 486 Score = 117 bits (294), Expect = 3e-27, Method: Composition-based stats. Identities = 38/121 (31%), Positives = 64/121 (52%), Gaps = 5/121 (4%) Query: 76 PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG-ANPDA 134 PLH +A G E++ LL + VN ++ + P+HYA + E +LLE G NP+ Sbjct: 41 PLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNL 100 Query: 135 KDHYEATAMHRAAAKGNLKMIHILLYY-KASTNIQDTEGNTPLHLA---CDEERVEEAKL 190 + ++ +H AA G+ +++ ILL + + +I D +G +PL++ E AKL Sbjct: 101 LNGQLSSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNICEENKQNNWEEAAKL 160 Query: 191 L 191 L Sbjct: 161 L 161 Score = 100 bits (248), Expect = 7e-22, Method: Composition-based stats. Identities = 34/122 (27%), Positives = 54/122 (44%), Gaps = 7/122 (5%) Query: 29 DKSLATRTDQDSRT-----ALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASA 83 +S+++ T+ R LH + G +E++ LL VN D W+P+H A Sbjct: 22 QRSMSSVTEDKERQWVDDFPLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWY 81 Query: 84 GRDEIVKALLGKG-AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG-GANPDAKDHYEAT 141 G+ E + LL KG N +N +PLH+AA EI +LL + D + Sbjct: 82 GKVEATRILLEKGKCNPNLLNGQLSSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRS 141 Query: 142 AM 143 + Sbjct: 142 PL 143 Score = 87.7 bits (216), Expect = 4e-18, Method: Composition-based stats. Identities = 38/129 (29%), Positives = 55/129 (42%), Gaps = 6/129 (4%) Query: 5 VSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLG- 63 V + + A G EL +L+++ + D D +H+AC G E LL+ G Sbjct: 37 VDDFPLHRSACEGD-SELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGK 95 Query: 64 VPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG-AQVNAVNQNGCTPLHYA---ASKNRH 119 N + SPLH AA G EIV+ LL + +Q G +PL+ N Sbjct: 96 CNPNLLNGQLSSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNICEENKQNNWE 155 Query: 120 EIAVMLLEG 128 E A +L E Sbjct: 156 EAAKLLKEA 164 Score = 71.9 bits (175), Expect = 2e-13, Method: Composition-based stats. Identities = 23/84 (27%), Positives = 47/84 (55%), Gaps = 1/84 (1%) Query: 142 AMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQG-ASIYI 200 +HR+A +G+ +++ LL + S N D++ P+H AC +VE ++L+ +G + + Sbjct: 41 PLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNL 100 Query: 201 ENKEEKTPLQVAKGGLGLILKRMV 224 N + +PL A GG + +++ Sbjct: 101 LNGQLSSPLHFAAGGGHAEIVQIL 124 Score = 70.0 bits (170), Expect = 8e-13, Method: Composition-based stats. Identities = 24/111 (21%), Positives = 50/111 (45%), Gaps = 2/111 (1%) Query: 109 PLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK-ASTNI 167 PLH +A + E+ LL + + D +H A G ++ ILL + N+ Sbjct: 41 PLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGKCNPNL 100 Query: 168 QDTEGNTPLHLACDEERVEEAKLLVSQ-GASIYIENKEEKTPLQVAKGGLG 217 + + ++PLH A E ++L++ +I +++ ++PL + + Sbjct: 101 LNGQLSSPLHFAAGGGHAEIVQILLNHPETDRHITDQQGRSPLNICEENKQ 151 >5DND-A nrPDB Length = 588 Score = 116 bits (290), Expect = 9e-27, Method: Composition-based stats. Identities = 42/145 (28%), Positives = 69/145 (47%), Gaps = 1/145 (0%) Query: 48 CSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGC 107 AG E ++ L++LG + KD G + LH+AA GRD +V LL +G VNA +++G Sbjct: 430 AHAGELEALQALMELGSDLRLKDSNGQTLLHVAARNGRDGVVTMLLHRGMDVNARDRDGL 489 Query: 108 TPLHYAASKNRHEIAVMLLEGGANPDAKDHYE-ATAMHRAAAKGNLKMIHILLYYKASTN 166 +PL A E +L + GA +D + T + R A++ +++ + A Sbjct: 490 SPLLLAVQGRHRECIRLLRKAGACLSPQDLKDAGTELCRLASRADMEGLQAWGQAGADLQ 549 Query: 167 IQDTEGNTPLHLACDEERVEEAKLL 191 +G + L +A E LL Sbjct: 550 QPGYDGRSALCVAEAAGNQEVLALL 574 Score = 96.2 bits (238), Expect = 9e-21, Method: Composition-based stats. Identities = 42/151 (27%), Positives = 72/151 (47%), Gaps = 2/151 (1%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVND 68 + LA++G+LE L+ ++ S D + +T LH A G +V LL G+ VN Sbjct: 425 LALALAHAGELEALQA-LMELGSDLRLKDSNGQTLLHVAARNGRDGVVTMLLHRGMDVNA 483 Query: 69 KDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN-QNGCTPLHYAASKNRHEIAVMLLE 127 +D G SPL +A E ++ L GA ++ + ++ T L AS+ E + Sbjct: 484 RDRDGLSPLLLAVQGRHRECIRLLRKAGACLSPQDLKDAGTELCRLASRADMEGLQAWGQ 543 Query: 128 GGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158 GA+ + +A+ A A GN +++ +L Sbjct: 544 AGADLQQPGYDGRSALCVAEAAGNQEVLALL 574 Score = 73.5 bits (179), Expect = 7e-14, Method: Composition-based stats. Identities = 26/89 (29%), Positives = 41/89 (46%) Query: 114 ASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGN 173 A E L+E G++ KD T +H AA G ++ +LL+ N +D +G Sbjct: 430 AHAGELEALQALMELGSDLRLKDSNGQTLLHVAARNGRDGVVTMLLHRGMDVNARDRDGL 489 Query: 174 TPLHLACDEERVEEAKLLVSQGASIYIEN 202 +PL LA E +LL GA + ++ Sbjct: 490 SPLLLAVQGRHRECIRLLRKAGACLSPQD 518 Score = 63.5 bits (153), Expect = 7e-11, Method: Composition-based stats. Identities = 18/78 (23%), Positives = 37/78 (47%) Query: 147 AAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEK 206 A G L+ + L+ + ++D+ G T LH+A R +L+ +G + +++ Sbjct: 430 AHAGELEALQALMELGSDLRLKDSNGQTLLHVAARNGRDGVVTMLLHRGMDVNARDRDGL 489 Query: 207 TPLQVAKGGLGLILKRMV 224 +PL +A G R++ Sbjct: 490 SPLLLAVQGRHRECIRLL 507 >6E2G-A nrPDB Length = 727 Score = 115 bits (287), Expect = 2e-26, Method: Composition-based stats. Identities = 45/200 (22%), Positives = 79/200 (39%), Gaps = 29/200 (14%) Query: 42 TALHWACSAGHTEIVEFLLQ-LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQV- 99 + L A + + + LL+ G V+ K G + LHIAA E L+ ++ Sbjct: 47 SPLLLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLMEAAPELV 106 Query: 100 ----NAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD-------------HYEATA 142 + G T LH A + LL GA+ A+ +Y Sbjct: 107 FEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHP 166 Query: 143 MHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV----EEAKLLVSQGASI 198 + AA G+ +++ +L+ + A QD+ GNT LH+ + + LL+S Sbjct: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGGD 226 Query: 199 YIE------NKEEKTPLQVA 212 +++ N + TP ++A Sbjct: 227 HLKSLELVPNNQGLTPFKLA 246 Score = 107 bits (268), Expect = 4e-24, Method: Composition-based stats. Identities = 49/214 (22%), Positives = 84/214 (39%), Gaps = 28/214 (13%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVND 68 + A ++ L + + + + TALH A + E L++ + Sbjct: 48 PLLLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLMEAAPELVF 107 Query: 69 KDD-----AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN-------------GCTPL 110 + G + LHIA +V+ALL +GA V+A G PL Sbjct: 108 EPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPL 167 Query: 111 HYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNL----KMIHILLYYKASTN 166 +AA EI +L+E GA+ A+D T +H + N +M ++LL Y + Sbjct: 168 SFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGGDH 227 Query: 167 ------IQDTEGNTPLHLACDEERVEEAKLLVSQ 194 + + +G TP LA E + + L+ + Sbjct: 228 LKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQK 261 Score = 107 bits (267), Expect = 4e-24, Method: Composition-based stats. Identities = 48/198 (24%), Positives = 71/198 (35%), Gaps = 29/198 (14%) Query: 2 EGCVSNLMVCNLAYSGKLEELKESILADKSLA----TRTDQDSRTALHWACSAGHTEIVE 57 +G + + A LE + A L T + +TALH A + +V Sbjct: 75 KGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVINQNVNLVR 134 Query: 58 FLLQLGVPVNDKDDA-------------GWSPLHIAASAGRDEIVKALLGKGAQVNAVNQ 104 LL G V+ + G PL AA G +EIV+ L+ GA + A + Sbjct: 135 ALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDS 194 Query: 105 NGCTPLHYAASKNRHEIAVMLLEGGANPDAKDH----------YEATAMHRAAAKGNLKM 154 G T LH + A + + D DH T A +GN+ M Sbjct: 195 LGNTVLHILILQPNKTFACQMYNLLLSYDGGDHLKSLELVPNNQGLTPFKLAGVEGNIVM 254 Query: 155 IHILLYYKASTNIQDTEG 172 L+ + +IQ T G Sbjct: 255 FQHLMQKR--KHIQWTYG 270 Score = 79.6 bits (195), Expect = 1e-15, Method: Composition-based stats. Identities = 32/158 (20%), Positives = 48/158 (30%), Gaps = 52/158 (32%) Query: 106 GCTPLHYAASKNRHEIAVMLLEG-GANPDAKDHYEATAMHRAA----------------- 147 +PL AA +N + + LL+ G K TA+H AA Sbjct: 45 WESPLLLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAALYDNLEAAMVLMEAAPE 104 Query: 148 ---------------------AKGNLKMIHILLYYKASTNIQDT-------------EGN 173 N+ ++ LL AS + + T G Sbjct: 105 LVFEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGE 164 Query: 174 TPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV 211 PL A E +LL+ GA I ++ T L + Sbjct: 165 HPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHI 202 Score = 39.2 bits (90), Expect = 0.001, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 20/42 (47%), Gaps = 1/42 (2%) Query: 173 NTPLHLACDEERVEEAKLLVS-QGASIYIENKEEKTPLQVAK 213 +PL LA E V+ L+ +G ++ + +T L +A Sbjct: 46 ESPLLLAAKENNVQALIKLLKFEGCEVHQKGAMGETALHIAA 87 >1BLX-B nrPDB Length = 166 Score = 110 bits (274), Expect = 6e-25, Method: Composition-based stats. Identities = 37/146 (25%), Positives = 66/146 (45%), Gaps = 2/146 (1%) Query: 13 LAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA 72 A G ++E++ + + ++ +TAL G + LL+ G N +D + Sbjct: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSPAVALELLKQGASPNVQDAS 73 Query: 73 GWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP 132 G SP+H AA G + +K L+ GA VNA++ G P+H A + + L ++ Sbjct: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNALDSTGSLPIHLAIREGHSSVVSFL-APESDL 132 Query: 133 DAKDHYEATAMHRAAAKGNLKMIHIL 158 +D T + A +G ++ IL Sbjct: 133 HHRDASGLTPLELARQRGAQNLMDIL 158 Score = 95.8 bits (237), Expect = 1e-20, Method: Composition-based stats. Identities = 37/149 (24%), Positives = 66/149 (44%), Gaps = 3/149 (2%) Query: 47 ACSAGHTEIVEFLL-QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN 105 A + G + V LL + V + + G + L + G + LL +GA N + + Sbjct: 15 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSPAVALELLKQGASPNVQDAS 73 Query: 106 GCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAST 165 G +P+H AA + +L+E GA+ +A D + +H A +G+ ++ L ++ Sbjct: 74 GTSPVHDAARTGFLDTLKVLVEHGADVNALDSTGSLPIHLAIREGHSSVVSFLAP-ESDL 132 Query: 166 NIQDTEGNTPLHLACDEERVEEAKLLVSQ 194 + +D G TPL LA +L Sbjct: 133 HHRDASGLTPLELARQRGAQNLMDILQGH 161 Score = 93.1 bits (230), Expect = 9e-20, Method: Composition-based stats. Identities = 41/151 (27%), Positives = 74/151 (49%), Gaps = 3/151 (1%) Query: 77 LHIAASAGRDEIVKALLGKG-AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAK 135 L AA+ G + V+ LL + +A+N+ G T L +A+ LL+ GA+P+ + Sbjct: 12 LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSPAVALELLKQGASPNVQ 70 Query: 136 DHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQG 195 D + +H AA G L + +L+ + A N D+ G+ P+HLA E L + Sbjct: 71 DASGTSPVHDAARTGFLDTLKVLVEHGADVNALDSTGSLPIHLAIREGHSSVVSFLAPE- 129 Query: 196 ASIYIENKEEKTPLQVAKGGLGLILKRMVEG 226 + ++ + TPL++A+ L +++G Sbjct: 130 SDLHHRDASGLTPLELARQRGAQNLMDILQG 160 >1BD8-A nrPDB Length = 156 Score = 108 bits (269), Expect = 3e-24, Method: Composition-based stats. Identities = 39/146 (26%), Positives = 65/146 (44%), Gaps = 2/146 (1%) Query: 13 LAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA 72 A G ++E++ + + ++ +TAL G T I LL+ G N +D + Sbjct: 9 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQDTS 67 Query: 73 GWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP 132 G SP+H AA G + +K L+ GA VN + G P+H A + V L ++ Sbjct: 68 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGH-TAVVSFLAAESDL 126 Query: 133 DAKDHYEATAMHRAAAKGNLKMIHIL 158 +D T + A +G ++ IL Sbjct: 127 HRRDARGLTPLELALQRGAQDLVDIL 152 Score = 97.4 bits (241), Expect = 5e-21, Method: Composition-based stats. Identities = 38/149 (25%), Positives = 66/149 (44%), Gaps = 3/149 (2%) Query: 47 ACSAGHTEIVEFLL-QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN 105 A + G + V LL + V + + G + L + G I LL +GA N + + Sbjct: 9 AAARGDVQEVRRLLHRELVHPDALNRFGKTALQV-MMFGSTAIALELLKQGASPNVQDTS 67 Query: 106 GCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAST 165 G +P+H AA + +L+E GA+ + D A +H A +G+ ++ L ++ Sbjct: 68 GTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFL-AAESDL 126 Query: 166 NIQDTEGNTPLHLACDEERVEEAKLLVSQ 194 + +D G TPL LA + +L Sbjct: 127 HRRDARGLTPLELALQRGAQDLVDILQGH 155 Score = 90.8 bits (224), Expect = 4e-19, Method: Composition-based stats. Identities = 42/151 (27%), Positives = 73/151 (48%), Gaps = 3/151 (1%) Query: 77 LHIAASAGRDEIVKALLGKG-AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAK 135 L AA+ G + V+ LL + +A+N+ G T L IA+ LL+ GA+P+ + Sbjct: 6 LSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQ-VMMFGSTAIALELLKQGASPNVQ 64 Query: 136 DHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQG 195 D + +H AA G L + +L+ + A N+ D G P+HLA E L ++ Sbjct: 65 DTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAE- 123 Query: 196 ASIYIENKEEKTPLQVAKGGLGLILKRMVEG 226 + ++ + TPL++A L +++G Sbjct: 124 SDLHRRDARGLTPLELALQRGAQDLVDILQG 154 >2RFA-A nrPDB Length = 232 Score = 103 bits (257), Expect = 6e-23, Method: Composition-based stats. Identities = 44/200 (22%), Positives = 78/200 (39%), Gaps = 29/200 (14%) Query: 42 TALHWACSAGHTEIVEFLLQ-LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQV- 99 + L A + + LL+ G V+ + G + LHIAA E L+ ++ Sbjct: 5 SPLLLAAKENDVQALSKLLKFEGCEVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELV 64 Query: 100 ----NAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD-------------HYEATA 142 + G T LH A + LL GA+ A+ +Y Sbjct: 65 FEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHP 124 Query: 143 MHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV----EEAKLLVSQGASI 198 + AA G+ +++ +L+ + A QD+ GNT LH+ + + LL+S Sbjct: 125 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGGD 184 Query: 199 YIE------NKEEKTPLQVA 212 +++ N + TP ++A Sbjct: 185 HLKSLELVPNNQGLTPFKLA 204 Score = 95.8 bits (237), Expect = 1e-20, Method: Composition-based stats. Identities = 49/214 (22%), Positives = 84/214 (39%), Gaps = 28/214 (13%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVND 68 + A ++ L + + + + TALH A + E L++ + Sbjct: 6 PLLLAAKENDVQALSKLLKFEGCEVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVF 65 Query: 69 KDD-----AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN-------------GCTPL 110 + G + LHIA +V+ALL +GA V+A G PL Sbjct: 66 EPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPL 125 Query: 111 HYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNL----KMIHILLYYKASTN 166 +AA EI +L+E GA+ A+D T +H + N +M ++LL Y + Sbjct: 126 SFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGGDH 185 Query: 167 ------IQDTEGNTPLHLACDEERVEEAKLLVSQ 194 + + +G TP LA E + + L+ + Sbjct: 186 LKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQK 219 Score = 91.2 bits (225), Expect = 3e-19, Method: Composition-based stats. Identities = 44/185 (23%), Positives = 64/185 (34%), Gaps = 27/185 (14%) Query: 3 GCVSNLMVCNLAYSGKLEELKESILADKSLA----TRTDQDSRTALHWACSAGHTEIVEF 58 G + + A LE + A L T + +TALH A + +V Sbjct: 34 GAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVINQNVNLVRA 93 Query: 59 LLQLGVPVNDKDDA-------------GWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN 105 LL G V+ + G PL AA G +EIV+ L+ GA + A + Sbjct: 94 LLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSL 153 Query: 106 GCTPLHYAASKNRHEIAVMLLEGGANPDAKDH----------YEATAMHRAAAKGNLKMI 155 G T LH + A + + D DH T A +GN+ M Sbjct: 154 GNTVLHILILQPNKTFACQMYNLLLSYDGGDHLKSLELVPNNQGLTPFKLAGVEGNIVMF 213 Query: 156 HILLY 160 L+ Sbjct: 214 QHLMQ 218 Score = 35.0 bits (79), Expect = 0.026, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 19/42 (45%), Gaps = 1/42 (2%) Query: 173 NTPLHLACDEERVEEAKLLVS-QGASIYIENKEEKTPLQVAK 213 +PL LA E V+ L+ +G ++ +T L +A Sbjct: 4 ESPLLLAAKENDVQALSKLLKFEGCEVHQRGAMGETALHIAA 45 >6DMR-A nrPDB Length = 730 Score = 102 bits (255), Expect = 1e-22, Method: Composition-based stats. Identities = 55/216 (25%), Positives = 84/216 (38%), Gaps = 31/216 (14%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVND 68 + A L LK +L + TALH A + E L++ P Sbjct: 48 PLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLEAATLLME-AAPELA 106 Query: 69 KDDA------GWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN-------------GCTP 109 K+ A G + LHIA +V+ALL +GA V+A G P Sbjct: 107 KEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHP 166 Query: 110 LHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNL----KMIHILLYYKAST 165 L +AA EI +L+E GA+ A+D T +H + N +M ++LL Y + Sbjct: 167 LSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHS 226 Query: 166 NI-------QDTEGNTPLHLACDEERVEEAKLLVSQ 194 + + +G TP LA E + L+ + Sbjct: 227 DHLQSLELVPNHQGLTPFKLAGVEGNTVMFQHLMQK 262 Score = 99.7 bits (247), Expect = 1e-21, Method: Composition-based stats. Identities = 39/157 (24%), Positives = 58/157 (36%), Gaps = 26/157 (16%) Query: 40 SRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA-------------GWSPLHIAASAGRD 86 +TALH A + +V LL G V+ + G PL AA G + Sbjct: 117 GQTALHIAVMNQNLNLVRALLARGASVSARATGAAFRRSPHNLIYYGEHPLSFAACVGSE 176 Query: 87 EIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD-----------AK 135 EIV+ L+ GA + A + G T LH + A + + D Sbjct: 177 EIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDEHSDHLQSLELVP 236 Query: 136 DHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172 +H T A +GN M L+ + ++Q T G Sbjct: 237 NHQGLTPFKLAGVEGNTVMFQHLMQKR--KHVQWTCG 271 Score = 98.9 bits (245), Expect = 1e-21, Method: Composition-based stats. Identities = 42/214 (19%), Positives = 77/214 (35%), Gaps = 30/214 (14%) Query: 29 DKSLATRTDQDSRTALHWACSAGHTEIVEFLL-QLGVPVNDKDDAGWSPLHIAASAGRDE 87 D+ + ++ + L A +++ LL + G + LH+AA E Sbjct: 34 DRVNMLQQERIRDSPLLQAAKENDLRLLKILLLNQSCDFQQRGAVGETALHVAALYDNLE 93 Query: 88 IVKALLGKGAQVNAVNQN-----GCTPLHYAASKNRHEIAVMLLEGGANPDAKD------ 136 L+ ++ G T LH A + LL GA+ A+ Sbjct: 94 AATLLMEAAPELAKEPALCEPFVGQTALHIAVMNQNLNLVRALLARGASVSARATGAAFR 153 Query: 137 -------HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV---- 185 +Y + AA G+ +++ +L+ + A QD+ GNT LH+ + Sbjct: 154 RSPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFAC 213 Query: 186 EEAKLLVSQGASIY-------IENKEEKTPLQVA 212 + LL+S + N + TP ++A Sbjct: 214 QMYNLLLSYDEHSDHLQSLELVPNHQGLTPFKLA 247 >4BSZ-B nrPDB Length = 202 Score = 100 bits (249), Expect = 5e-22, Method: Composition-based stats. Identities = 38/152 (25%), Positives = 68/152 (44%), Gaps = 28/152 (18%) Query: 14 AYSGKLEELKES---ILADKSLAT-RTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 A +G L+ LK+ +++ + L+T + + TALH A + GH E V ++L+ N Sbjct: 22 ARAGDLDSLKDIFTTLVSPELLSTCKESESDSTALHMAAANGHIETVRYILETVSRANSA 81 Query: 70 DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLL-EG 128 +D +KA VN VN+ G T LH+A+ + ++ +L E Sbjct: 82 ED-----------------LKAF------VNEVNKTGNTALHWASLNGKLDVVKLLCDEY 118 Query: 129 GANPDAKDHYEATAMHRAAAKGNLKMIHILLY 160 A+P ++ + A+ A G ++ L Sbjct: 119 EADPFIRNKFGHDAIFEAENSGKEEVETYFLK 150 Score = 61.2 bits (147), Expect = 3e-10, Method: Composition-based stats. Identities = 22/98 (22%), Positives = 40/98 (40%), Gaps = 11/98 (11%) Query: 108 TPLHYAASKNRHEIAVMLLE----------GGANPDAKDHYEATAMHRAAAKGNLKMIHI 157 T LH AA+ E +LE A + + TA+H A+ G L ++ + Sbjct: 54 TALHMAAANGHIETVRYILETVSRANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVVKL 113 Query: 158 LL-YYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQ 194 L Y+A I++ G+ + A + + E + + Sbjct: 114 LCDEYEADPFIRNKFGHDAIFEAENSGKEEVETYFLKK 151 Score = 60.4 bits (145), Expect = 6e-10, Method: Composition-based stats. Identities = 25/88 (28%), Positives = 41/88 (46%), Gaps = 11/88 (12%) Query: 139 EATAMHRAAAKGNLKMIHILLY----------YKASTNIQDTEGNTPLHLACDEERVEEA 188 ++TA+H AAA G+++ + +L KA N + GNT LH A +++ Sbjct: 52 DSTALHMAAANGHIETVRYILETVSRANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVV 111 Query: 189 KLLVSQG-ASIYIENKEEKTPLQVAKGG 215 KLL + A +I NK + A+ Sbjct: 112 KLLCDEYEADPFIRNKFGHDAIFEAENS 139 Score = 38.0 bits (87), Expect = 0.004, Method: Composition-based stats. Identities = 12/62 (19%), Positives = 23/62 (37%), Gaps = 10/62 (16%) Query: 173 NTPLHLACDEERVEEAKLLVS----------QGASIYIENKEEKTPLQVAKGGLGLILKR 222 +T LH+A +E + ++ A + NK T L A L + + Sbjct: 53 STALHMAAANGHIETVRYILETVSRANSAEDLKAFVNEVNKTGNTALHWASLNGKLDVVK 112 Query: 223 MV 224 ++ Sbjct: 113 LL 114 >5UIL-A nrPDB Length = 405 Score = 99.3 bits (246), Expect = 1e-21, Method: Composition-based stats. Identities = 33/143 (23%), Positives = 63/143 (44%), Gaps = 4/143 (2%) Query: 23 KESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAAS 82 KE I++ +D+ + AC ++ + L++ + +K+ GWSP+ +AA Sbjct: 261 KEIIVSTIDYDVVLYKDNFKEILEACKYSDSKYIAKLIRAKSILFEKNIYGWSPVIVAAY 320 Query: 83 AGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASK----NRHEIAVMLLEGGANPDAKDHY 138 G E++K L+ KGA +N N G T Y + ML++ G + D+ Sbjct: 321 HGNIELIKWLVSKGANINDRNYKGTTVAMYFKDYMLKSGDYSGLKMLIDLGLDLTLTDYK 380 Query: 139 EATAMHRAAAKGNLKMIHILLYY 161 + T GN ++ ++ + Sbjct: 381 DYTVFDYLEKSGNKNLLQYMMAF 403 Score = 50.0 bits (118), Expect = 8e-07, Method: Composition-based stats. Identities = 23/127 (18%), Positives = 52/127 (40%), Gaps = 5/127 (3%) Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163 ++ + A + + L+ + K+ Y + + AA GN+++I L+ A Sbjct: 276 KDNFKEILEACKYSDSKYIAKLIRAKSILFEKNIYGWSPVIVAAYHGNIELIKWLVSKGA 335 Query: 164 STNIQDTEGNTPLHLACDE----ERVEEAKLLVSQGASIYIENKEEKTPLQ-VAKGGLGL 218 + N ++ +G T D K+L+ G + + + ++ T + K G Sbjct: 336 NINDRNYKGTTVAMYFKDYMLKSGDYSGLKMLIDLGLDLTLTDYKDYTVFDYLEKSGNKN 395 Query: 219 ILKRMVE 225 +L+ M+ Sbjct: 396 LLQYMMA 402 >1G3N-B nrPDB Length = 168 Score = 97.0 bits (240), Expect = 6e-21, Method: Composition-based stats. Identities = 52/138 (37%), Positives = 67/138 (48%), Gaps = 2/138 (1%) Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136 L AA+ G E + +LL VNA N G T L EIA LL GANPD KD Sbjct: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQ-VMKLGNPEIARRLLLRGANPDLKD 67 Query: 137 HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGA 196 +H AA G L + LL ++A NI+D EGN PLHLA E + + LV A Sbjct: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127 Query: 197 -SIYIENKEEKTPLQVAK 213 ++ N + T +A+ Sbjct: 128 SNVGHRNHKGDTACDLAR 145 Score = 96.6 bits (239), Expect = 8e-21, Method: Composition-based stats. Identities = 44/156 (28%), Positives = 70/156 (44%), Gaps = 3/156 (1%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 + + A G LE+L +L + + RTAL G+ EI LL G + K Sbjct: 9 LASAAARGDLEQLTS-LLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLK 66 Query: 70 DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG 129 D G++ +H AA AG + ++ LL A VN + G PLH AA + + L++ Sbjct: 67 DRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHT 126 Query: 130 A-NPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAS 164 A N ++H TA A G +++ ++ A Sbjct: 127 ASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAG 162 Score = 96.2 bits (238), Expect = 9e-21, Method: Composition-based stats. Identities = 43/151 (28%), Positives = 75/151 (49%), Gaps = 2/151 (1%) Query: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNG 106 A + G E + LLQ V VN ++ G + L + G EI + LL +GA + ++ G Sbjct: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKDRTG 70 Query: 107 CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA-ST 165 +H AA + LLE A+ + +D+ +H AA +G+L+++ L+ + A + Sbjct: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130 Query: 166 NIQDTEGNTPLHLACDEERVEEAKLLVSQGA 196 ++ +G+T LA R E L+ + GA Sbjct: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161 Score = 64.6 bits (156), Expect = 3e-11, Method: Composition-based stats. Identities = 28/115 (24%), Positives = 52/115 (45%), Gaps = 1/115 (0%) Query: 110 LHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQD 169 L AA++ E LL+ N +A++ + TA+ GN ++ LL A+ +++D Sbjct: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKD 67 Query: 170 TEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMV 224 G +H A ++ + L+ A + IE+ E PL +A L + + Sbjct: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFL 122 Score = 29.6 bits (65), Expect = 1.2, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 20/58 (34%) Query: 7 NLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGV 64 NL + A G L ++ + S + TA A G E+V + G Sbjct: 104 NLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161 >3UI2-A nrPDB Length = 244 Score = 97.0 bits (240), Expect = 6e-21, Method: Composition-based stats. Identities = 32/106 (30%), Positives = 52/106 (49%), Gaps = 2/106 (1%) Query: 75 SPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134 +P AA ++ + LL + V+AV++NG T L + A + +L E GA+ D Sbjct: 47 TPWWTAARKADEQALSQLL-EDRDVDAVDENGRTALLFVAGLGSDKCVRLLAEAGADLDH 105 Query: 135 KDHYEA-TAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179 +D TA+H AA +++ L+ A ++D G T L LA Sbjct: 106 RDMRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELA 151 Score = 81.6 bits (200), Expect = 2e-16, Method: Composition-based stats. Identities = 31/106 (29%), Positives = 49/106 (46%), Gaps = 2/106 (1%) Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101 T A + + LL+ V+ D+ G + L A G D+ V+ L GA ++ Sbjct: 47 TPWWTAARKADEQALSQLLEDR-DVDAVDENGRTALLFVAGLGSDKCVRLLAEAGADLDH 105 Query: 102 VN-QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146 + + G T LH AA R E+ L+E GA+ + +D TA+ A Sbjct: 106 RDMRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELA 151 Score = 81.6 bits (200), Expect = 3e-16, Method: Composition-based stats. Identities = 36/111 (32%), Positives = 52/111 (46%), Gaps = 2/111 (1%) Query: 108 TPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNI 167 TP AA K + LLE + DA D TA+ A G+ K + +L A + Sbjct: 47 TPWWTAARKADEQALSQLLED-RDVDAVDENGRTALLFVAGLGSDKCVRLLAEAGADLDH 105 Query: 168 QDTEGN-TPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLG 217 +D G T LH+A R E + LV GA I +E++ T L++A+ L Sbjct: 106 RDMRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELAREILK 156 Score = 80.0 bits (196), Expect = 7e-16, Method: Composition-based stats. Identities = 28/102 (27%), Positives = 47/102 (46%), Gaps = 3/102 (2%) Query: 13 LAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKD-D 71 A + L + + D++ RTAL + G + V L + G ++ +D Sbjct: 52 AARKADEQALSQLLEDR--DVDAVDENGRTALLFVAGLGSDKCVRLLAEAGADLDHRDMR 109 Query: 72 AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYA 113 G + LH+AA R E+V+AL+ GA + ++ G T L A Sbjct: 110 GGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELA 151 >3DEO-A nrPDB Length = 183 Score = 95.8 bits (237), Expect = 1e-20, Method: Composition-based stats. Identities = 32/106 (30%), Positives = 52/106 (49%), Gaps = 2/106 (1%) Query: 75 SPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134 +P AA ++ + LL + V+AV++NG T L + A + +L E GA+ D Sbjct: 46 TPWWTAARKADEQALSQLL-EDRDVDAVDENGRTALLFVAGLGSDKCVRLLAEAGADLDH 104 Query: 135 KDHYEA-TAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179 +D TA+H AA +++ L+ A ++D G T L LA Sbjct: 105 RDMRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELA 150 Score = 80.8 bits (198), Expect = 4e-16, Method: Composition-based stats. Identities = 31/106 (29%), Positives = 49/106 (46%), Gaps = 2/106 (1%) Query: 42 TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101 T A + + LL+ V+ D+ G + L A G D+ V+ L GA ++ Sbjct: 46 TPWWTAARKADEQALSQLLEDR-DVDAVDENGRTALLFVAGLGSDKCVRLLAEAGADLDH 104 Query: 102 VN-QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146 + + G T LH AA R E+ L+E GA+ + +D TA+ A Sbjct: 105 RDMRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELA 150 Score = 80.8 bits (198), Expect = 4e-16, Method: Composition-based stats. Identities = 36/111 (32%), Positives = 52/111 (46%), Gaps = 2/111 (1%) Query: 108 TPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNI 167 TP AA K + LLE + DA D TA+ A G+ K + +L A + Sbjct: 46 TPWWTAARKADEQALSQLLED-RDVDAVDENGRTALLFVAGLGSDKCVRLLAEAGADLDH 104 Query: 168 QDTEGN-TPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLG 217 +D G T LH+A R E + LV GA I +E++ T L++A+ L Sbjct: 105 RDMRGGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELAREILK 155 Score = 79.3 bits (194), Expect = 1e-15, Method: Composition-based stats. Identities = 28/102 (27%), Positives = 47/102 (46%), Gaps = 3/102 (2%) Query: 13 LAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKD-D 71 A + L + + D++ RTAL + G + V L + G ++ +D Sbjct: 51 AARKADEQALSQLLEDR--DVDAVDENGRTALLFVAGLGSDKCVRLLAEAGADLDHRDMR 108 Query: 72 AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYA 113 G + LH+AA R E+V+AL+ GA + ++ G T L A Sbjct: 109 GGLTALHMAAGYVRPEVVEALVELGADIEVEDERGLTALELA 150 >2KXP-C nrPDB Length = 118 Score = 95.0 bits (235), Expect = 2e-20, Method: Composition-based stats. Identities = 35/96 (36%), Positives = 46/96 (47%), Gaps = 1/96 (1%) Query: 15 YSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGW 74 +G L+E+K+ +A RT + R LH+A G EI+EFLL G +N D Sbjct: 11 KNGDLDEVKDY-VAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHI 69 Query: 75 SPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPL 110 +PL A G VK LL KGA +G T L Sbjct: 70 TPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAL 105 Score = 85.0 bits (209), Expect = 2e-17, Method: Composition-based stats. Identities = 34/100 (34%), Positives = 49/100 (49%) Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103 WA G + V+ + G VN + G PLH AA G+ EI++ LL KGA +NA + Sbjct: 6 FMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPD 65 Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAM 143 ++ TPL A + +LL GA+ K TA+ Sbjct: 66 KHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAL 105 Score = 82.3 bits (202), Expect = 1e-16, Method: Composition-based stats. Identities = 36/114 (31%), Positives = 54/114 (47%), Gaps = 4/114 (3%) Query: 80 AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139 A G + VK + KG VN + G PLHYAA + EI LL GA+ +A D + Sbjct: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHH 68 Query: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVS 193 T + A +G++ + +LL A ++ +G T L A D + K L+ Sbjct: 69 ITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTALE-ATDN---QAIKALLQ 118 Score = 80.8 bits (198), Expect = 4e-16, Method: Composition-based stats. Identities = 26/100 (26%), Positives = 40/100 (40%) Query: 110 LHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQD 169 +A + + G + + +H AA G L+++ LL A N D Sbjct: 6 FMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPD 65 Query: 170 TEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPL 209 TPL A E V KLL+S+GA ++ + T L Sbjct: 66 KHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAL 105 Score = 27.6 bits (60), Expect = 4.4, Method: Composition-based stats. Identities = 9/46 (19%), Positives = 18/46 (39%) Query: 179 ACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMV 224 A ++E K V++G + + + PL A L + + Sbjct: 9 ALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFL 54 >3T9K-A nrPDB Length = 390 Score = 94.3 bits (233), Expect = 4e-20, Method: Composition-based stats. Identities = 34/101 (33%), Positives = 44/101 (43%), Gaps = 2/101 (1%) Query: 27 LADKSLATRTD--QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84 LA + + QD+ T L A +A EFLLQ G VN D AG PLH A G Sbjct: 220 LAHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILG 279 Query: 85 RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125 + L +GA + A + G PL A +I +L Sbjct: 280 HTGLACLFLKRGADLGARDSEGRDPLTIAMETANADIVTLL 320 Score = 90.0 bits (222), Expect = 6e-19, Method: Composition-based stats. Identities = 32/101 (31%), Positives = 45/101 (44%), Gaps = 2/101 (1%) Query: 93 LGKGAQVNAVN--QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKG 150 L GA VN VN Q+ TPL A + N LL+ GAN + D +H A G Sbjct: 220 LAHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILG 279 Query: 151 NLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLL 191 + + + L A +D+EG PL +A + + LL Sbjct: 280 HTGLACLFLKRGADLGARDSEGRDPLTIAMETANADIVTLL 320 Score = 74.6 bits (182), Expect = 3e-14, Method: Composition-based stats. Identities = 28/101 (27%), Positives = 43/101 (42%), Gaps = 2/101 (1%) Query: 60 LQLGVPVNDKD--DAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKN 117 L G VN + +PL A +A + LL GA VN + G PLH+A Sbjct: 220 LAHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILG 279 Query: 118 RHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158 +A + L+ GA+ A+D + A N ++ +L Sbjct: 280 HTGLACLFLKRGADLGARDSEGRDPLTIAMETANADIVTLL 320 Score = 70.0 bits (170), Expect = 8e-13, Method: Composition-based stats. Identities = 26/101 (25%), Positives = 43/101 (42%), Gaps = 2/101 (1%) Query: 126 LEGGANPDAKD--HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEE 183 L GA+ + + AT + +A A +L LL A+ N D+ G PLH A Sbjct: 220 LAHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILG 279 Query: 184 RVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMV 224 A L + +GA + + E + PL +A + ++ Sbjct: 280 HTGLACLFLKRGADLGARDSEGRDPLTIAMETANADIVTLL 320 Score = 57.3 bits (137), Expect = 5e-09, Method: Composition-based stats. Identities = 21/69 (30%), Positives = 30/69 (43%) Query: 24 ESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASA 83 E +L + + + D R LH A GHT + L+ G + +D G PL IA Sbjct: 252 EFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGADLGARDSEGRDPLTIAMET 311 Query: 84 GRDEIVKAL 92 +IV L Sbjct: 312 ANADIVTLL 320 >3EHQ-A nrPDB Length = 222 Score = 87.7 bits (216), Expect = 3e-18, Method: Composition-based stats. Identities = 35/96 (36%), Positives = 51/96 (53%), Gaps = 2/96 (2%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL-QLGVPVN 67 + A G L L+E L ++ D+ TAL+WAC GH +IVE L Q + +N Sbjct: 76 PLHEAAKRGNLSWLRE-CLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELN 134 Query: 68 DKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103 ++ G + LH AA G +IV+ LL KGA+ + N Sbjct: 135 QQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRN 170 Score = 84.6 bits (208), Expect = 3e-17, Method: Composition-based stats. Identities = 32/120 (26%), Positives = 54/120 (45%), Gaps = 4/120 (3%) Query: 76 PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLL-EGGANPDA 134 PLH AA G ++ L VN +++ G T L++A +I ML + + Sbjct: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135 Query: 135 KDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQ 194 ++ TA+H AA KG ++ +LL A T++++ E +A A LL + Sbjct: 136 QNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMAT---NAACASLLKKK 192 Score = 84.3 bits (207), Expect = 4e-17, Method: Composition-based stats. Identities = 34/115 (29%), Positives = 51/115 (44%), Gaps = 1/115 (0%) Query: 43 ALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK-GAQVNA 101 LH A G+ + L V VN D AG + L+ A G +IV+ L + ++N Sbjct: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135 Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156 N+ G T LH AA K +I +LL GA D ++ + A A ++ Sbjct: 136 QNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLLK 190 Score = 83.5 bits (205), Expect = 7e-17, Method: Composition-based stats. Identities = 29/119 (24%), Positives = 52/119 (43%), Gaps = 1/119 (0%) Query: 109 PLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK-ASTNI 167 PLH AA + L+ + D +TA++ A G+ ++ +L N Sbjct: 76 PLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQ 135 Query: 168 QDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG 226 Q+ G+T LH A + + +LL+++GA + N E+K +A L + +G Sbjct: 136 QNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLLKKKQG 194 Score = 44.6 bits (104), Expect = 3e-05, Method: Composition-based stats. Identities = 17/88 (19%), Positives = 35/88 (39%), Gaps = 3/88 (3%) Query: 3 GCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQL 62 G + C+ G + ++ + ++ TALH A G+ +IV+ LL Sbjct: 106 GSTALYWACH---GGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAK 162 Query: 63 GVPVNDKDDAGWSPLHIAASAGRDEIVK 90 G + ++ +A +A ++K Sbjct: 163 GARTDLRNIEKKLAFDMATNAACASLLK 190 >5UQE-A nrPDB Length = 520 Score = 87.3 bits (215), Expect = 5e-18, Method: Composition-based stats. Identities = 33/92 (35%), Positives = 47/92 (51%), Gaps = 4/92 (4%) Query: 2 EGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61 V NL+ AY+G + L+ L+ + R D DSRTALH A + GH E+V+FLL+ Sbjct: 415 VKSVINLLFA--AYTGDVSALRRFALSAMDMEQR-DYDSRTALHVAAAEGHVEVVKFLLE 471 Query: 62 L-GVPVNDKDDAGWSPLHIAASAGRDEIVKAL 92 V KD +P+ A G ++ K L Sbjct: 472 ACKVNPFPKDRWNNTPMDEALHFGHHDVFKIL 503 Score = 70.8 bits (172), Expect = 5e-13, Method: Composition-based stats. Identities = 24/87 (27%), Positives = 36/87 (41%), Gaps = 1/87 (1%) Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG-GANPDAK 135 L AA G ++ + + + T LH AA++ E+ LLE NP K Sbjct: 421 LLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPK 480 Query: 136 DHYEATAMHRAAAKGNLKMIHILLYYK 162 D + T M A G+ + IL Y+ Sbjct: 481 DRWNNTPMDEALHFGHHDVFKILQEYQ 507 Score = 61.2 bits (147), Expect = 4e-10, Method: Composition-based stats. Identities = 22/87 (25%), Positives = 39/87 (44%), Gaps = 3/87 (3%) Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN--A 101 L +A G + + + +D + LH+AA+ G E+VK LL + +VN Sbjct: 421 LLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLL-EACKVNPFP 479 Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEG 128 ++ TP+ A H++ +L E Sbjct: 480 KDRWNNTPMDEALHFGHHDVFKILQEY 506 Score = 60.4 bits (145), Expect = 7e-10, Method: Composition-based stats. Identities = 21/83 (25%), Positives = 38/83 (45%), Gaps = 1/83 (1%) Query: 110 LHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY-KASTNIQ 168 L +AA + + +D+ TA+H AAA+G+++++ LL K + + Sbjct: 421 LLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPK 480 Query: 169 DTEGNTPLHLACDEERVEEAKLL 191 D NTP+ A + K+L Sbjct: 481 DRWNNTPMDEALHFGHHDVFKIL 503 Score = 47.7 bits (112), Expect = 4e-06, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 30/71 (42%), Gaps = 1/71 (1%) Query: 143 MHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQ-GASIYIE 201 + AA G++ + +D + T LH+A E VE K L+ + + + Sbjct: 421 LLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPK 480 Query: 202 NKEEKTPLQVA 212 ++ TP+ A Sbjct: 481 DRWNNTPMDEA 491 >5U0K-A nrPDB Length = 141 Score = 86.6 bits (213), Expect = 8e-18, Method: Composition-based stats. Identities = 35/91 (38%), Positives = 47/91 (51%), Gaps = 4/91 (4%) Query: 3 GCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQL 62 V NL+ AYSG + L+ L+ + + D DSRTALH A + GH E+V+FL++ Sbjct: 24 KTVVNLLFA--AYSGDVSALRRFALSAMDMEQK-DYDSRTALHVAAAEGHIEVVKFLIEA 80 Query: 63 -GVPVNDKDDAGWSPLHIAASAGRDEIVKAL 92 V KD G PL A E+VK L Sbjct: 81 CKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 111 Score = 67.7 bits (164), Expect = 4e-12, Method: Composition-based stats. Identities = 21/87 (24%), Positives = 39/87 (44%), Gaps = 1/87 (1%) Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG-GANPDAK 135 L AA +G ++ + + + T LH AA++ E+ L+E NP AK Sbjct: 29 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAK 88 Query: 136 DHYEATAMHRAAAKGNLKMIHILLYYK 162 D + + A +L+++ +L Y+ Sbjct: 89 DRWGNIPLDDAVQFNHLEVVKLLQDYQ 115 Score = 61.9 bits (149), Expect = 2e-10, Method: Composition-based stats. Identities = 24/84 (28%), Positives = 39/84 (46%), Gaps = 3/84 (3%) Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN--A 101 L +A +G + + + KD + LH+AA+ G E+VK L + +VN A Sbjct: 29 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVK-FLIEACKVNPFA 87 Query: 102 VNQNGCTPLHYAASKNRHEIAVML 125 ++ G PL A N E+ +L Sbjct: 88 KDRWGNIPLDDAVQFNHLEVVKLL 111 Score = 50.8 bits (120), Expect = 5e-07, Method: Composition-based stats. Identities = 16/84 (19%), Positives = 35/84 (41%), Gaps = 1/84 (1%) Query: 143 MHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQ-GASIYIE 201 + AA G++ + +D + T LH+A E +E K L+ + + + Sbjct: 29 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAK 88 Query: 202 NKEEKTPLQVAKGGLGLILKRMVE 225 ++ PL A L + ++++ Sbjct: 89 DRWGNIPLDDAVQFNHLEVVKLLQ 112 >5U0J-A nrPDB Length = 140 Score = 83.1 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 34/93 (36%), Positives = 48/93 (51%), Gaps = 4/93 (4%) Query: 1 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60 M V NL+ AY+G + L+ L+ + R D DSRTALH A + GH E+V+FLL Sbjct: 21 MVKSVINLLFA--AYTGDVSALRRFALSAMDMEQR-DYDSRTALHVAAAEGHVEVVKFLL 77 Query: 61 QL-GVPVNDKDDAGWSPLHIAASAGRDEIVKAL 92 + V KD +P+ A G ++ K L Sbjct: 78 EACKVNPFPKDRWNNTPMDEALHFGHHDVFKIL 110 Score = 65.8 bits (159), Expect = 1e-11, Method: Composition-based stats. Identities = 24/87 (27%), Positives = 36/87 (41%), Gaps = 1/87 (1%) Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG-GANPDAK 135 L AA G ++ + + + T LH AA++ E+ LLE NP K Sbjct: 28 LLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPK 87 Query: 136 DHYEATAMHRAAAKGNLKMIHILLYYK 162 D + T M A G+ + IL Y+ Sbjct: 88 DRWNNTPMDEALHFGHHDVFKILQEYQ 114 Score = 56.5 bits (135), Expect = 9e-09, Method: Composition-based stats. Identities = 22/87 (25%), Positives = 39/87 (44%), Gaps = 3/87 (3%) Query: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN--A 101 L +A G + + + +D + LH+AA+ G E+VK LL + +VN Sbjct: 28 LLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLL-EACKVNPFP 86 Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEG 128 ++ TP+ A H++ +L E Sbjct: 87 KDRWNNTPMDEALHFGHHDVFKILQEY 113 Score = 56.1 bits (134), Expect = 1e-08, Method: Composition-based stats. Identities = 21/83 (25%), Positives = 38/83 (45%), Gaps = 1/83 (1%) Query: 110 LHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY-KASTNIQ 168 L +AA + + +D+ TA+H AAA+G+++++ LL K + + Sbjct: 28 LLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPK 87 Query: 169 DTEGNTPLHLACDEERVEEAKLL 191 D NTP+ A + K+L Sbjct: 88 DRWNNTPMDEALHFGHHDVFKIL 110 Score = 44.6 bits (104), Expect = 3e-05, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 30/71 (42%), Gaps = 1/71 (1%) Query: 143 MHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQ-GASIYIE 201 + AA G++ + +D + T LH+A E VE K L+ + + + Sbjct: 28 LLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPK 87 Query: 202 NKEEKTPLQVA 212 ++ TP+ A Sbjct: 88 DRWNNTPMDEA 98 >4XD0-A nrPDB Length = 417 Score = 82.7 bits (203), Expect = 1e-16, Method: Composition-based stats. Identities = 30/138 (21%), Positives = 56/138 (40%), Gaps = 4/138 (2%) Query: 25 SILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84 IL+ + D+ + AC E + LL+ + +K+ GWSP+ IAA G Sbjct: 276 LILSTIDYDIKLYSDNFDEILTACEDKSPEFISKLLKTENILFEKNHLGWSPIIIAAYHG 335 Query: 85 RDEIVKALLGKGAQVNAVNQNGCTPLHYAASK----NRHEIAVMLLEGGANPDAKDHYEA 140 ++++ L+ KG +N N G T Y + L+ G + KD+ Sbjct: 336 NMDVIEWLVSKGVNINDRNYKGTTVAMYFKDYMLRSGNYTGLENLINLGLDLFLKDNEGL 395 Query: 141 TAMHRAAAKGNLKMIHIL 158 + N+++ + + Sbjct: 396 SVFDYMRKNKNIELFNFM 413 Score = 53.1 bits (126), Expect = 1e-07, Method: Composition-based stats. Identities = 20/121 (16%), Positives = 44/121 (36%), Gaps = 4/121 (3%) Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163 + + A E LL+ K+H + + AA GN+ +I L+ Sbjct: 289 SDNFDEILTACEDKSPEFISKLLKTENILFEKNHLGWSPIIIAAYHGNMDVIEWLVSKGV 348 Query: 164 STNIQDTEGNTPLHLACDE----ERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLI 219 + N ++ +G T D + L++ G +++++ E + + + Sbjct: 349 NINDRNYKGTTVAMYFKDYMLRSGNYTGLENLINLGLDLFLKDNEGLSVFDYMRKNKNIE 408 Query: 220 L 220 L Sbjct: 409 L 409 >1DCQ-A nrPDB Length = 278 Score = 78.1 bits (191), Expect = 3e-15, Method: Composition-based stats. Identities = 37/154 (24%), Positives = 61/154 (39%), Gaps = 18/154 (11%) Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML-LEGGANPDAKDHYE 139 A + L V + G A + ++ + L G PD Sbjct: 120 ARKKHADTAAKLHSLCEAVKTRDIFGL----LQAYADGVDLTEKIPLANGHEPD------ 169 Query: 140 ATAMHRAAA---KGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGA 196 TA+H A + +L ++ L+ + + Q +G+T LH C + E KLL+ A Sbjct: 170 ETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKA 229 Query: 197 SIYIENKEEKTPLQVAK----GGLGLILKRMVEG 226 SI I N+ +TPL +AK +L + + G Sbjct: 230 SIEIANESGETPLDIAKRLKHEHCEELLTQALSG 263 Score = 57.7 bits (138), Expect = 4e-09, Method: Composition-based stats. Identities = 29/130 (22%), Positives = 50/130 (38%), Gaps = 11/130 (8%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTD--------QDSRTALHWACSA---GHTEIVEF 58 + +L + K ++ + A T+ + TALH A + IV+F Sbjct: 131 LHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDF 190 Query: 59 LLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNR 118 L+Q ++ + G + LH E +K LL A + N++G TPL A Sbjct: 191 LVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKH 250 Query: 119 HEIAVMLLEG 128 +L + Sbjct: 251 EHCEELLTQA 260 >5AN8-A nrPDB Length = 613 Score = 76.9 bits (188), Expect = 7e-15, Method: Composition-based stats. Identities = 54/225 (24%), Positives = 82/225 (36%), Gaps = 46/225 (20%) Query: 16 SGKLEELKESILADKSLATRTDQDSRTALHWAC---SAGHTEIVEFLLQLGVP------- 65 +G LE L+ + +T L A G ++ LL++ Sbjct: 16 AGLLEYLRRTSKYLTDSEYTEGSTGKTCLMKAVLNLQDGVNACIQPLLEIDRDSGNPQPL 75 Query: 66 VNDKDDA----GWSPLHIAASAGRDEIVKALLGKGAQVNAVN-------------QNGCT 108 VN + G S LHIA + VK L+ GA V+A G Sbjct: 76 VNAQCTDEYYRGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGEL 135 Query: 109 PLHYAASKNRHEIAVMLLEG---GANPDAKDHYEATAMHRAAAKGN---------LKMIH 156 PL AA + ++ LLE A+ A+D T +H + ++M Sbjct: 136 PLSLAACTKQWDVVNYLLENPHPAASLQAQDSLGNTVLHALVMIADNSPENSALVVRMYD 195 Query: 157 ILLYYKAS--TNIQ-----DTEGNTPLHLACDEERVEEAKLLVSQ 194 LL A N+Q + EG TPL LA E ++E K ++ + Sbjct: 196 GLLQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQR 240 Score = 73.1 bits (178), Expect = 8e-14, Method: Composition-based stats. Identities = 35/157 (22%), Positives = 60/157 (38%), Gaps = 32/157 (20%) Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKD-------------DAGWSPLHIAASAG 84 +ALH A + V+ L++ G V+ K G PL +AA Sbjct: 85 YRGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTK 144 Query: 85 RDEIVKALLGKG---AQVNAVNQNGCTPLHYAAS------KNRHEIAVM---LLEGGA-- 130 + ++V LL A + A + G T LH +N + M LL+ GA Sbjct: 145 QWDVVNYLLENPHPAASLQAQDSLGNTVLHALVMIADNSPENSALVVRMYDGLLQAGARL 204 Query: 131 NPDAK-----DHYEATAMHRAAAKGNLKMIHILLYYK 162 P+ + + T + AA +G +++ +L + Sbjct: 205 CPNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQRE 241 Score = 49.2 bits (116), Expect = 2e-06, Method: Composition-based stats. Identities = 29/139 (20%), Positives = 49/139 (35%), Gaps = 35/139 (25%) Query: 110 LHYAASKNRHEIAVMLLEGG--ANPDAKDH------YEATAMHRAAAK---GNLKMIHIL 158 L ++ E LLE + D T + +A G I L Sbjct: 3 LFNVVARGNPEDLAGLLEYLRRTSKYLTDSEYTEGSTGKTCLMKAVLNLQDGVNACIQPL 62 Query: 159 LYYKAS-------TNIQDTE----GNTPLHLACDEERVEEAKLLVSQGASIYI------- 200 L N Q T+ G++ LH+A ++ ++ KLLV GA+++ Sbjct: 63 LEIDRDSGNPQPLVNAQCTDEYYRGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFF 122 Query: 201 -ENK-----EEKTPLQVAK 213 +N+ + PL +A Sbjct: 123 QKNQDTCFYFGELPLSLAA 141 Score = 28.4 bits (62), Expect = 2.6, Method: Composition-based stats. Identities = 8/28 (28%), Positives = 11/28 (39%) Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPV 66 + T L A G EI + +LQ Sbjct: 217 EGLTPLKLAAKEGKIEIFKHILQREFSA 244 >6OO7-A nrPDB Length = 786 Score = 75.8 bits (185), Expect = 1e-14, Method: Composition-based stats. Identities = 54/225 (24%), Positives = 82/225 (36%), Gaps = 46/225 (20%) Query: 16 SGKLEELKESILADKSLATRTDQDSRTALHWAC---SAGHTEIVEFLLQLGVP------- 65 +G LE L+ + +T L A G ++ LL++ Sbjct: 91 AGLLEYLRRTSKYLTDSEYTEGSTGKTCLMKAVLNLQDGVNACIQPLLEIDRDSGNPQPL 150 Query: 66 VNDKDDA----GWSPLHIAASAGRDEIVKALLGKGAQVNAVN-------------QNGCT 108 VN + G S LHIA + VK L+ GA V+A G Sbjct: 151 VNAQCTDEYYRGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGEL 210 Query: 109 PLHYAASKNRHEIAVMLLEG---GANPDAKDHYEATAMHRAAAKGN---------LKMIH 156 PL AA + ++ LLE A+ A+D T +H + ++M Sbjct: 211 PLSLAACTKQWDVVNYLLENPHQPASLQAQDSLGNTVLHALVMIADDSAENSALVVRMYD 270 Query: 157 ILLYYKAS--TNIQ-----DTEGNTPLHLACDEERVEEAKLLVSQ 194 LL A N+Q + EG TPL LA E ++E K ++ + Sbjct: 271 GLLQAGARLCPNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQR 315 Score = 73.1 bits (178), Expect = 8e-14, Method: Composition-based stats. Identities = 35/157 (22%), Positives = 60/157 (38%), Gaps = 32/157 (20%) Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKD-------------DAGWSPLHIAASAG 84 +ALH A + V+ L++ G V+ K G PL +AA Sbjct: 160 YRGHSALHIAIEKRSLQCVKLLVENGANVHAKACGHFFQKNQDTCFYFGELPLSLAACTK 219 Query: 85 RDEIVKALLGKG---AQVNAVNQNGCTPLHYAAS------KNRHEIAVM---LLEGGA-- 130 + ++V LL A + A + G T LH +N + M LL+ GA Sbjct: 220 QWDVVNYLLENPHQPASLQAQDSLGNTVLHALVMIADDSAENSALVVRMYDGLLQAGARL 279 Query: 131 NPDAK-----DHYEATAMHRAAAKGNLKMIHILLYYK 162 P+ + + T + AA +G +++ +L + Sbjct: 280 CPNVQLEGIPNLEGLTPLKLAAKEGKIEIFKHILQRE 316 Score = 49.2 bits (116), Expect = 1e-06, Method: Composition-based stats. Identities = 32/153 (20%), Positives = 54/153 (35%), Gaps = 35/153 (22%) Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG--ANPDAKDH------YEATAMHRAA 147 GA +N+ L ++ E LLE + D T + +A Sbjct: 64 GASQPDLNRFDRDRLFNVVARGNPEDLAGLLEYLRRTSKYLTDSEYTEGSTGKTCLMKAV 123 Query: 148 AK---GNLKMIHILLYYKAS-------TNIQDTE----GNTPLHLACDEERVEEAKLLVS 193 G I LL N Q T+ G++ LH+A ++ ++ KLLV Sbjct: 124 LNLQDGVNACIQPLLEIDRDSGNPQPLVNAQCTDEYYRGHSALHIAIEKRSLQCVKLLVE 183 Query: 194 QGASIYI--------ENK-----EEKTPLQVAK 213 GA+++ +N+ + PL +A Sbjct: 184 NGANVHAKACGHFFQKNQDTCFYFGELPLSLAA 216 Score = 28.4 bits (62), Expect = 2.6, Method: Composition-based stats. Identities = 8/28 (28%), Positives = 11/28 (39%) Query: 39 DSRTALHWACSAGHTEIVEFLLQLGVPV 66 + T L A G EI + +LQ Sbjct: 292 EGLTPLKLAAKEGKIEIFKHILQREFSA 319 >1D9S-A nrPDB Length = 136 Score = 74.6 bits (182), Expect = 3e-14, Method: Composition-based stats. Identities = 37/122 (30%), Positives = 59/122 (48%), Gaps = 2/122 (1%) Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136 L AA+ G+ E V+ LL GA NA+N+ G P+ ++A +LL GA P+ D Sbjct: 16 LATAAARGQVETVRQLLEAGADPNALNRFGRRPIQ-VMMMGSAQVAELLLLHGAEPNCAD 74 Query: 137 HYEAT-AMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQG 195 T +H AA +G L + +L A ++ D G P+ LA ++ + A+ L + Sbjct: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVCDAWGRLPVDLAEEQGHRDIARYLHAAT 134 Query: 196 AS 197 Sbjct: 135 GD 136 Score = 69.2 bits (168), Expect = 1e-12, Method: Composition-based stats. Identities = 30/126 (23%), Positives = 55/126 (43%), Gaps = 3/126 (2%) Query: 1 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60 M G S+ + A G++E +++ + A + ++ R + G ++ E LL Sbjct: 7 MLGGSSDAGLATAAARGQVETVRQLLEA-GADPNALNRFGRRPIQV-MMMGSAQVAELLL 64 Query: 61 QLGVPVNDKDDAGWS-PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRH 119 G N D A + P+H AA G + + L GA+++ + G P+ A + Sbjct: 65 LHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVCDAWGRLPVDLAEEQGHR 124 Query: 120 EIAVML 125 +IA L Sbjct: 125 DIARYL 130 Score = 64.6 bits (156), Expect = 3e-11, Method: Composition-based stats. Identities = 27/113 (23%), Positives = 53/113 (46%), Gaps = 2/113 (1%) Query: 113 AASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172 AA++ + E LLE GA+P+A + + + G+ ++ +LL + A N D Sbjct: 19 AAARGQVETVRQLLEAGADPNALNRFGRRPIQV-MMMGSAQVAELLLLHGAEPNCADPAT 77 Query: 173 NT-PLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMV 224 T P+H A E ++ +L GA + + + + P+ +A+ + R + Sbjct: 78 LTRPVHDAAREGFLDTLVVLHRAGARLDVCDAWGRLPVDLAEEQGHRDIARYL 130 Score = 36.5 bits (83), Expect = 0.010, Method: Composition-based stats. Identities = 12/61 (19%), Positives = 25/61 (40%) Query: 164 STNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRM 223 ++ + L A +VE + L+ GA N+ + P+QV G + + + Sbjct: 4 GIHMLGGSSDAGLATAAARGQVETVRQLLEAGADPNALNRFGRRPIQVMMMGSAQVAELL 63 Query: 224 V 224 + Sbjct: 64 L 64 >5IRX-A nrPDB Length = 636 Score = 71.6 bits (174), Expect = 2e-13, Method: Composition-based stats. Identities = 37/188 (19%), Positives = 68/188 (36%), Gaps = 38/188 (20%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVND 68 ++ ++A K + LK+ + A + + +TALH A + +V L++ G V Sbjct: 70 LLLDVAR--KTDSLKQFVNASYTDSY---YKGQTALHIAIERRNMTLVTLLVENGADVQA 124 Query: 69 KDDA--------------GWSPLHIAASAGRDEIVKALLGK---GAQVNAVNQNGCTPLH 111 + G PL +AA + IVK LL A ++A + G T LH Sbjct: 125 AANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLH 184 Query: 112 YAAS-----KNRHEIAVMLLE----GGANPD-------AKDHYEATAMHRAAAKGNLKMI 155 + + + GA + T + AA+ G + ++ Sbjct: 185 ALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVL 244 Query: 156 HILLYYKA 163 +L + Sbjct: 245 AYILQREI 252 Score = 70.8 bits (172), Expect = 5e-13, Method: Composition-based stats. Identities = 46/204 (22%), Positives = 80/204 (39%), Gaps = 52/204 (25%) Query: 71 DAGWSPLHIA---ASAGRDEIVKALLGKGAQVNAVNQ-----------NGCTPLHYAASK 116 + G + L A G+++ + LL + +++ Q G T LH A + Sbjct: 47 ETGKTCLLKAMLNLHNGQNDTIALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIAIER 106 Query: 117 NRHEIAVMLLEGGANPDA---KDHYEAT-----------AMHRAAAKGNLKMIHILLYY- 161 + +L+E GA+ A D ++ T + AA L ++ LL Sbjct: 107 RNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNS 166 Query: 162 --KASTNIQDTEGNTPLH--LACDEERVEEAKL-------LVSQGASIY-------IENK 203 A + +D+ GNT LH + + V+ K ++ GA ++ I N+ Sbjct: 167 WQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNR 226 Query: 204 EEKTPLQVAK-----GGLGLILKR 222 + TPL +A G L IL+R Sbjct: 227 KGLTPLALAASSGKIGVLAYILQR 250 Score = 44.2 bits (103), Expect = 5e-05, Method: Composition-based stats. Identities = 23/116 (19%), Positives = 36/116 (31%), Gaps = 28/116 (24%) Query: 137 HYEATAMHRA---AAKGNLKMIHILL-------YYKASTNIQDT----EGNTPLHLACDE 182 T + +A G I +LL K N T +G T LH+A + Sbjct: 47 ETGKTCLLKAMLNLHNGQNDTIALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIAIER 106 Query: 183 ERVEEAKLLVSQGASIYIENK--------------EEKTPLQVAKGGLGLILKRMV 224 + LLV GA + + PL +A L + + + Sbjct: 107 RNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFL 162 >6DVZ-A nrPDB Length = 791 Score = 71.2 bits (173), Expect = 3e-13, Method: Composition-based stats. Identities = 51/235 (21%), Positives = 82/235 (34%), Gaps = 56/235 (23%) Query: 16 SGKLEELKESILADKSLATR---------------TDQDSRTALHWACSA---GHTEIVE 57 G +EEL+E + + L R +T L A EIV Sbjct: 129 EGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVR 188 Query: 58 FLLQLGVPVNDKDD-----------AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN- 105 LL + D G + L+IA + +I L+ GA VNA + Sbjct: 189 ILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIERRQGDITAVLIAAGADVNAHAKGV 248 Query: 106 -------------GCTPLHYAASKNRHEIAVMLLEGG-ANPDAKDHYEATAMHRAAAKGN 151 G TPL AA N+ EI +L+E + ++D +H Sbjct: 249 FFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAE 308 Query: 152 ---------LKMIHILLYYKAS---TNIQDTEGNTPLHLACDEERVEEAKLLVSQ 194 +M ++L + +++ +G TPL LA + E K ++S+ Sbjct: 309 DFKTQNDFVKRMYDMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSR 363 Score = 65.4 bits (158), Expect = 2e-11, Method: Composition-based stats. Identities = 36/176 (20%), Positives = 53/176 (30%), Gaps = 45/176 (25%) Query: 80 AASAGRDEIVKALLG---------KGAQVNA-------VNQNGCTPLHYAASK---NRHE 120 A S G E ++ LL +G V + G T L A N E Sbjct: 126 AVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTASDTGKTCLMKALLNINPNTKE 185 Query: 121 IAVMLLEGGANPDAKDHY-----------EATAMHRAAAKGNLKMIHILLYYKASTNIQD 169 I +LL D D + TA++ A + + +L+ A N Sbjct: 186 IVRILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIERRQGDITAVLIAAGADVNAHA 245 Query: 170 T--------------EGNTPLHLACDEERVEEAKLLVSQ-GASIYIENKEEKTPLQ 210 G TPL LA + E +LL+ I ++ L Sbjct: 246 KGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILH 301 Score = 63.1 bits (152), Expect = 1e-10, Method: Composition-based stats. Identities = 35/178 (19%), Positives = 67/178 (37%), Gaps = 30/178 (16%) Query: 13 LAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA 72 LA++ + + L I A+ T + +TAL+ A +I L+ G VN Sbjct: 191 LAFAEENDILDRFINAEY---TEEAYEGQTALNIAIERRQGDITAVLIAAGADVNAHAKG 247 Query: 73 --------------GWSPLHIAASAGRDEIVKALLGKGA-QVNAVNQNGCTPLHYAA--- 114 G +PL +AA + EIV+ L+ + + + G LH Sbjct: 248 VFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVA 307 Query: 115 --SKNRHEIAV------MLLEGGANPDA-KDHYEATAMHRAAAKGNLKMIHILLYYKA 163 K +++ +L G + +++ T + AA G +++ +L + Sbjct: 308 EDFKTQNDFVKRMYDMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSREI 365 Score = 37.3 bits (85), Expect = 0.005, Method: Composition-based stats. Identities = 20/99 (20%), Positives = 42/99 (42%), Gaps = 12/99 (12%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALH--WACSAG---HTEIVE-----F 58 + A + + E ++ + +++ T D LH + + V+ Sbjct: 265 PLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMI 324 Query: 59 LLQLGV--PVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95 LL+ G +++ G +PL +AA G+ EI+K +L + Sbjct: 325 LLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSR 363 >2A5E-A nrPDB Length = 156 Score = 70.8 bits (172), Expect = 5e-13, Method: Composition-based stats. Identities = 39/116 (33%), Positives = 56/116 (48%), Gaps = 2/116 (1%) Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136 L AA+ GR E V+ALL GA NA N G P+ +A +LL GA P+ D Sbjct: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLLLHGAEPNCAD 74 Query: 137 HYEAT-AMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLL 191 T +H AA +G L + +L A +++D G P+ LA + + A+ L Sbjct: 75 PATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130 Score = 66.9 bits (162), Expect = 7e-12, Method: Composition-based stats. Identities = 28/117 (23%), Positives = 49/117 (41%), Gaps = 3/117 (2%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 + A G++EE++ + A +L + R + G + E LL G N Sbjct: 16 LATAAARGRVEEVRALLEA-GALPNAPNSYGRRPIQV-MMMGSARVAELLLLHGAEPNCA 73 Query: 70 DDAGWS-PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125 D A + P+H AA G + + L GA+++ + G P+ A ++A L Sbjct: 74 DPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYL 130 Score = 63.1 bits (152), Expect = 1e-10, Method: Composition-based stats. Identities = 28/103 (27%), Positives = 49/103 (47%), Gaps = 2/103 (1%) Query: 113 AASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172 AA++ R E LLE GA P+A + Y + G+ ++ +LL + A N D Sbjct: 19 AAARGRVEEVRALLEAGALPNAPNSYGRRPIQV-MMMGSARVAELLLLHGAEPNCADPAT 77 Query: 173 NT-PLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKG 214 T P+H A E ++ +L GA + + + + P+ +A+ Sbjct: 78 LTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEE 120 Score = 32.6 bits (73), Expect = 0.14, Method: Composition-based stats. Identities = 13/36 (36%), Positives = 17/36 (47%) Query: 176 LHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV 211 L A RVEE + L+ GA N + P+QV Sbjct: 16 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQV 51 >6BO5-A nrPDB Length = 695 Score = 70.4 bits (171), Expect = 6e-13, Method: Composition-based stats. Identities = 47/203 (23%), Positives = 70/203 (34%), Gaps = 46/203 (22%) Query: 38 QDSRTALHWAC---SAGHTEIVEFLLQLGVP-------VNDKDDA----GWSPLHIAASA 83 +T L A G + LLQ+ VN + G S LHIA Sbjct: 75 STGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKPLVNAQCTDEFYQGHSALHIAIEK 134 Query: 84 GRDEIVKALLGKGAQVNAVN-------------QNGCTPLHYAASKNRHEIAVMLLEGG- 129 + VK L+ GA V+ G PL AA + ++ LLE Sbjct: 135 RSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPH 194 Query: 130 --ANPDAKDHYEATAMHRAAAKGN---------LKMIHILLYYKAST-------NIQDTE 171 A+ +A D T +H + + M LL A I + + Sbjct: 195 QPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQ 254 Query: 172 GNTPLHLACDEERVEEAKLLVSQ 194 G TPL LA E ++E + ++ + Sbjct: 255 GLTPLKLAAKEGKIEIFRHILQR 277 Score = 69.6 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 34/157 (21%), Positives = 59/157 (37%), Gaps = 32/157 (20%) Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKD-------------DAGWSPLHIAASAG 84 +ALH A + V+ L++ G V+ + G PL +AA Sbjct: 122 YQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTK 181 Query: 85 RDEIVKALLGKG---AQVNAVNQNGCTPLH----YAASKNRHEIAVM-----LLEGGANP 132 + ++V LL A + A + G T LH A + + V+ LL+ GA Sbjct: 182 QWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARL 241 Query: 133 DAK-------DHYEATAMHRAAAKGNLKMIHILLYYK 162 +H T + AA +G +++ +L + Sbjct: 242 CPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQRE 278 Score = 68.9 bits (167), Expect = 2e-12, Method: Composition-based stats. Identities = 51/245 (20%), Positives = 84/245 (34%), Gaps = 55/245 (22%) Query: 36 TDQDSRTALHWACSAGHTEIVEFLLQLGV--------PVNDKDDAGWSPLHIAA---SAG 84 D+ R L S G E + LL+ + G + L A G Sbjct: 32 PDRFDRDRLFSVVSRGVPEELTGLLEYLRWNSKYLTDSAYTEGSTGKTCLMKAVLNLQDG 91 Query: 85 RDEIVKALLGKGAQ-------VNAVNQN----GCTPLHYAASKNRHEIAVMLLEGGANPD 133 + + LL VNA + G + LH A K + +L+E GA+ Sbjct: 92 VNACIMPLLQIDKDSGNPKPLVNAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVH 151 Query: 134 AKD-------------HYEATAMHRAAAKGNLKMIHILLYY---KASTNIQDTEGNTPLH 177 + ++ + AA ++ LL AS D+ GNT LH Sbjct: 152 LRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLH 211 Query: 178 --LACDEERVEEAKL-------LVSQGAS--IYIE-----NKEEKTPLQV-AKGGLGLIL 220 + + E + L L+ GA ++ N + TPL++ AK G I Sbjct: 212 ALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIF 271 Query: 221 KRMVE 225 + +++ Sbjct: 272 RHILQ 276 >5HI9-A nrPDB Length = 770 Score = 70.4 bits (171), Expect = 6e-13, Method: Composition-based stats. Identities = 47/203 (23%), Positives = 70/203 (34%), Gaps = 46/203 (22%) Query: 38 QDSRTALHWAC---SAGHTEIVEFLLQLGVP-------VNDKDDA----GWSPLHIAASA 83 +T L A G + LLQ+ VN + G S LHIA Sbjct: 115 STGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKPLVNAQCTDEFYQGHSALHIAIEK 174 Query: 84 GRDEIVKALLGKGAQVNAVN-------------QNGCTPLHYAASKNRHEIAVMLLEGG- 129 + VK L+ GA V+ G PL AA + ++ LLE Sbjct: 175 RSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPH 234 Query: 130 --ANPDAKDHYEATAMHRAAAKGN---------LKMIHILLYYKAST-------NIQDTE 171 A+ +A D T +H + + M LL A I + + Sbjct: 235 QPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQ 294 Query: 172 GNTPLHLACDEERVEEAKLLVSQ 194 G TPL LA E ++E + ++ + Sbjct: 295 GLTPLKLAAKEGKIEIFRHILQR 317 Score = 69.6 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 34/157 (21%), Positives = 59/157 (37%), Gaps = 32/157 (20%) Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKD-------------DAGWSPLHIAASAG 84 +ALH A + V+ L++ G V+ + G PL +AA Sbjct: 162 YQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTK 221 Query: 85 RDEIVKALLGKG---AQVNAVNQNGCTPLH----YAASKNRHEIAVM-----LLEGGANP 132 + ++V LL A + A + G T LH A + + V+ LL+ GA Sbjct: 222 QWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARL 281 Query: 133 DAK-------DHYEATAMHRAAAKGNLKMIHILLYYK 162 +H T + AA +G +++ +L + Sbjct: 282 CPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQRE 318 Score = 68.9 bits (167), Expect = 2e-12, Method: Composition-based stats. Identities = 51/247 (20%), Positives = 84/247 (34%), Gaps = 55/247 (22%) Query: 34 TRTDQDSRTALHWACSAGHTEIVEFLLQLGV--------PVNDKDDAGWSPLHIAA---S 82 D+ R L S G E + LL+ + G + L A Sbjct: 70 QEPDRFDRDRLFSVVSRGVPEELTGLLEYLRWNSKYLTDSAYTEGSTGKTCLMKAVLNLQ 129 Query: 83 AGRDEIVKALLGKGAQ-------VNAVNQN----GCTPLHYAASKNRHEIAVMLLEGGAN 131 G + + LL VNA + G + LH A K + +L+E GA+ Sbjct: 130 DGVNACIMPLLQIDKDSGNPKPLVNAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGAD 189 Query: 132 PDAKD-------------HYEATAMHRAAAKGNLKMIHILLYY---KASTNIQDTEGNTP 175 + ++ + AA ++ LL AS D+ GNT Sbjct: 190 VHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTV 249 Query: 176 LH--LACDEERVEEAKL-------LVSQGAS--IYIE-----NKEEKTPLQV-AKGGLGL 218 LH + + E + L L+ GA ++ N + TPL++ AK G Sbjct: 250 LHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIE 309 Query: 219 ILKRMVE 225 I + +++ Sbjct: 310 IFRHILQ 316 >2F37-A nrPDB Length = 251 Score = 68.1 bits (165), Expect = 3e-12, Method: Composition-based stats. Identities = 32/157 (20%), Positives = 59/157 (37%), Gaps = 32/157 (20%) Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKD-------------DAGWSPLHIAASAG 84 +ALH A + V+ L++ G V+ + G PL +AA Sbjct: 93 YRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTK 152 Query: 85 RDEIVKALLGKG---AQVNAVNQNGCTPLHYAASKNRHEIAVM---------LLEGGANP 132 + ++V LL A + A + G T LH + + + LL+ GA Sbjct: 153 QWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARL 212 Query: 133 -------DAKDHYEATAMHRAAAKGNLKMIHILLYYK 162 D ++ + T + AA +G +++ +L + Sbjct: 213 CPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQRE 249 Score = 64.2 bits (155), Expect = 5e-11, Method: Composition-based stats. Identities = 49/203 (24%), Positives = 74/203 (36%), Gaps = 46/203 (22%) Query: 38 QDSRTALHWACSA---GHTEIVEFLLQLGVP-------VNDK--DDA--GWSPLHIAASA 83 +T L A G + LLQ+ VN + DD G S LHIA Sbjct: 46 STGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEK 105 Query: 84 GRDEIVKALLGKGAQVNAVN-------------QNGCTPLHYAASKNRHEIAVMLLEG-- 128 + VK L+ GA V+A G PL AA + ++ LLE Sbjct: 106 RSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPH 165 Query: 129 -GANPDAKDHYEATAMHRAAA-----KGNLKMIHI----LLYYKAST-------NIQDTE 171 A+ A D T +H N+ ++ LL A +I++ + Sbjct: 166 QPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQ 225 Query: 172 GNTPLHLACDEERVEEAKLLVSQ 194 TPL LA E ++E + ++ + Sbjct: 226 DLTPLKLAAKEGKIEIFRHILQR 248 Score = 56.5 bits (135), Expect = 9e-09, Method: Composition-based stats. Identities = 26/138 (18%), Positives = 50/138 (36%), Gaps = 30/138 (21%) Query: 103 NQNGCTPLHYAASK---NRHEIAVMLLEGGAN-------PDAK---DHY-EATAMHRAAA 148 G T L A + + LL+ + +A+ D+Y +A+H A Sbjct: 45 GSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIE 104 Query: 149 KGNLKMIHILLYYKASTNIQDT-------------EGNTPLHLACDEERVEEAKLLVSQ- 194 K +L+ + +L+ A+ + + G PL LA ++ + L+ Sbjct: 105 KRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENP 164 Query: 195 --GASIYIENKEEKTPLQ 210 AS+ + + T L Sbjct: 165 HQPASLQATDSQGNTVLH 182 Score = 42.3 bits (98), Expect = 2e-04, Method: Composition-based stats. Identities = 22/103 (21%), Positives = 37/103 (35%), Gaps = 27/103 (26%) Query: 138 YEATAMHRAAAK---GNLKMIHILLYYKAS-------TNIQDTE----GNTPLHLACDEE 183 T + +A G I LL N Q T+ G++ LH+A ++ Sbjct: 47 TGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKR 106 Query: 184 RVEEAKLLVSQGASIYIEN-------------KEEKTPLQVAK 213 ++ KLLV GA+++ + PL +A Sbjct: 107 SLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAA 149 >2NYJ-A nrPDB Length = 273 Score = 67.3 bits (163), Expect = 5e-12, Method: Composition-based stats. Identities = 37/188 (19%), Positives = 68/188 (36%), Gaps = 38/188 (20%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVND 68 ++ ++A K + LK+ + A + + +TALH A + +V L++ G V Sbjct: 75 LLLDVAR--KTDSLKQFVNASYTDSY---YKGQTALHIAIERRNMTLVTLLVENGADVQA 129 Query: 69 KDDA--------------GWSPLHIAASAGRDEIVKALLGK---GAQVNAVNQNGCTPLH 111 + G PL +AA + IVK LL A ++A + G T LH Sbjct: 130 AANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLH 189 Query: 112 YAAS-----KNRHEIAVMLLE----GGANPD-------AKDHYEATAMHRAAAKGNLKMI 155 + + + GA + T + AA+ G + ++ Sbjct: 190 ALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVL 249 Query: 156 HILLYYKA 163 +L + Sbjct: 250 AYILQREI 257 Score = 65.8 bits (159), Expect = 2e-11, Method: Composition-based stats. Identities = 46/204 (22%), Positives = 80/204 (39%), Gaps = 52/204 (25%) Query: 71 DAGWSPLHIA---ASAGRDEIVKALLGKGAQVNAVNQ-----------NGCTPLHYAASK 116 + G + L A G+++ + LL + +++ Q G T LH A + Sbjct: 52 ETGKTCLLKAMLNLHNGQNDTIALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIAIER 111 Query: 117 NRHEIAVMLLEGGANPDA---KDHYEAT-----------AMHRAAAKGNLKMIHILLYY- 161 + +L+E GA+ A D ++ T + AA L ++ LL Sbjct: 112 RNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNS 171 Query: 162 --KASTNIQDTEGNTPLH--LACDEERVEEAKL-------LVSQGASIY-------IENK 203 A + +D+ GNT LH + + V+ K ++ GA ++ I N+ Sbjct: 172 WQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNR 231 Query: 204 EEKTPLQVAK-----GGLGLILKR 222 + TPL +A G L IL+R Sbjct: 232 KGLTPLALAASSGKIGVLAYILQR 255 Score = 41.5 bits (96), Expect = 3e-04, Method: Composition-based stats. Identities = 23/116 (19%), Positives = 36/116 (31%), Gaps = 28/116 (24%) Query: 137 HYEATAMHRA---AAKGNLKMIHILL-------YYKASTNIQDT----EGNTPLHLACDE 182 T + +A G I +LL K N T +G T LH+A + Sbjct: 52 ETGKTCLLKAMLNLHNGQNDTIALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIAIER 111 Query: 183 ERVEEAKLLVSQGASIYIENK--------------EEKTPLQVAKGGLGLILKRMV 224 + LLV GA + + PL +A L + + + Sbjct: 112 RNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFL 167 >4N5Q-A nrPDB Length = 257 Score = 66.5 bits (161), Expect = 1e-11, Method: Composition-based stats. Identities = 51/235 (21%), Positives = 82/235 (34%), Gaps = 56/235 (23%) Query: 16 SGKLEELKESILADKSLATR---------------TDQDSRTALHWACSA---GHTEIVE 57 G +EEL+E + + L R +T L A EIV Sbjct: 13 EGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVR 72 Query: 58 FLLQLGVPVNDKDD-----------AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN- 105 LL + D G + L+IA + +I L+ GA VNA + Sbjct: 73 ILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIERRQGDITAVLIAAGADVNAHAKGV 132 Query: 106 -------------GCTPLHYAASKNRHEIAVMLLEGG-ANPDAKDHYEATAMHRAAAKGN 151 G TPL AA N+ EI +L+E + ++D +H Sbjct: 133 FFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAE 192 Query: 152 ---------LKMIHILLYYKAS---TNIQDTEGNTPLHLACDEERVEEAKLLVSQ 194 +M ++L + +++ +G TPL LA + E K ++S+ Sbjct: 193 DFKTQNDFVKRMYDMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSR 247 Score = 61.2 bits (147), Expect = 3e-10, Method: Composition-based stats. Identities = 36/176 (20%), Positives = 53/176 (30%), Gaps = 45/176 (25%) Query: 80 AASAGRDEIVKALLG---------KGAQVNA-------VNQNGCTPLHYAASK---NRHE 120 A S G E ++ LL +G V + G T L A N E Sbjct: 10 AVSEGCVEELRELLQDLQDLCRRRRGLDVPDFLMHKLTASDTGKTCLMKALLNINPNTKE 69 Query: 121 IAVMLLEGGANPDAKDHY-----------EATAMHRAAAKGNLKMIHILLYYKASTNIQD 169 I +LL D D + TA++ A + + +L+ A N Sbjct: 70 IVRILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIERRQGDITAVLIAAGADVNAHA 129 Query: 170 T--------------EGNTPLHLACDEERVEEAKLLVSQ-GASIYIENKEEKTPLQ 210 G TPL LA + E +LL+ I ++ L Sbjct: 130 KGVFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILH 185 Score = 58.8 bits (141), Expect = 2e-09, Method: Composition-based stats. Identities = 35/178 (19%), Positives = 67/178 (37%), Gaps = 30/178 (16%) Query: 13 LAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA 72 LA++ + + L I A+ T + +TAL+ A +I L+ G VN Sbjct: 75 LAFAEENDILDRFINAEY---TEEAYEGQTALNIAIERRQGDITAVLIAAGADVNAHAKG 131 Query: 73 --------------GWSPLHIAASAGRDEIVKALLGKGA-QVNAVNQNGCTPLHYAA--- 114 G +PL +AA + EIV+ L+ + + + G LH Sbjct: 132 VFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVA 191 Query: 115 --SKNRHEIAV------MLLEGGANPDA-KDHYEATAMHRAAAKGNLKMIHILLYYKA 163 K +++ +L G + +++ T + AA G +++ +L + Sbjct: 192 EDFKTQNDFVKRMYDMILLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSREI 249 Score = 35.3 bits (80), Expect = 0.024, Method: Composition-based stats. Identities = 20/99 (20%), Positives = 42/99 (42%), Gaps = 12/99 (12%) Query: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALH--WACSAG---HTEIVE-----F 58 + A + + E ++ + +++ T D LH + + V+ Sbjct: 149 PLALAACTNQPEIVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMI 208 Query: 59 LLQLGV--PVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95 LL+ G +++ G +PL +AA G+ EI+K +L + Sbjct: 209 LLRSGNWELETMRNNDGLTPLQLAAKMGKAEILKYILSR 247 >2ETB-A nrPDB Length = 256 Score = 65.4 bits (158), Expect = 2e-11, Method: Composition-based stats. Identities = 38/155 (24%), Positives = 57/155 (36%), Gaps = 32/155 (20%) Query: 72 AGWSPLHIAASAGRDEIVKALLGKGAQVNAVN-------------QNGCTPLHYAASKNR 118 G S LHIA + VK L+ GA V+ G PL AA + Sbjct: 89 QGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQ 148 Query: 119 HEIAVMLLEG---GANPDAKDHYEATAMHRAAAKGN---------LKMIHILLYYKAST- 165 ++ LLE A+ +A D T +H + + M LL A Sbjct: 149 WDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLC 208 Query: 166 ------NIQDTEGNTPLHLACDEERVEEAKLLVSQ 194 I + +G TPL LA E ++E + ++ + Sbjct: 209 PTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQR 243 Score = 63.1 bits (152), Expect = 9e-11, Method: Composition-based stats. Identities = 36/163 (22%), Positives = 61/163 (37%), Gaps = 33/163 (20%) Query: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD-------------HYEATA 142 AQ G + LH A K + +L+E GA+ + ++ Sbjct: 80 NAQCTDEFYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELP 139 Query: 143 MHRAAAKGNLKMIHILLYY---KASTNIQDTEGNTPLH--LACDEERVEEAKL------- 190 + AA ++ LL AS D+ GNT LH + + E + L Sbjct: 140 LSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDG 199 Query: 191 LVSQGAS--IYIE-----NKEEKTPLQV-AKGGLGLILKRMVE 225 L+ GA ++ N + TPL++ AK G I + +++ Sbjct: 200 LLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQ 242 Score = 43.8 bits (102), Expect = 6e-05, Method: Composition-based stats. Identities = 22/103 (21%), Positives = 37/103 (35%), Gaps = 27/103 (26%) Query: 138 YEATAMHRAAAK---GNLKMIHILLYYKAS-------TNIQDTE----GNTPLHLACDEE 183 T + +A G I LL N Q T+ G++ LH+A ++ Sbjct: 42 TGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKPLVNAQCTDEFYQGHSALHIAIEKR 101 Query: 184 RVEEAKLLVSQGASIYIEN-------------KEEKTPLQVAK 213 ++ KLLV GA +++ + PL +A Sbjct: 102 SLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAA 144 >6CV9-A nrPDB Length = 842 Score = 64.6 bits (156), Expect = 3e-11, Method: Composition-based stats. Identities = 33/149 (22%), Positives = 53/149 (35%), Gaps = 32/149 (21%) Query: 77 LHIAASAGRDEIVKALLG--KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134 AA G +V+ +L VN V+ G L A + EI +LL+ Sbjct: 13 FLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRV 72 Query: 135 KDHYEATAMHRAAAKGNLKMIHILLYYKA-------------------STNIQDTEGN-- 173 D A+ A +KG ++++ +L + A D +G Sbjct: 73 GD-----ALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRF 127 Query: 174 ----TPLHLACDEERVEEAKLLVSQGASI 198 TP+ LA + E L+ +GA I Sbjct: 128 SHDVTPIILAAHCQEYEIVHTLLRKGARI 156 Score = 53.1 bits (126), Expect = 1e-07, Method: Composition-based stats. Identities = 31/146 (21%), Positives = 46/146 (31%), Gaps = 32/146 (21%) Query: 47 ACSAGHTEIVEFLLQ--LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQ 104 A G+ +V +L+ + VN D G + L +A + EI + LL K + Sbjct: 16 AAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGD- 74 Query: 105 NGCTPLHYAASKNRHEIAVMLLEGGA--------------NPDAKDHYEA---------- 140 L A SK I +L A D Y Sbjct: 75 ----ALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHD 130 Query: 141 -TAMHRAAAKGNLKMIHILLYYKAST 165 T + AA +++H LL A Sbjct: 131 VTPIILAAHCQEYEIVHTLLRKGARI 156 Score = 51.5 bits (122), Expect = 3e-07, Method: Composition-based stats. Identities = 36/147 (24%), Positives = 53/147 (36%), Gaps = 31/147 (21%) Query: 10 VCNLAYSGKLEELKESILADKSL-ATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVND 68 + A G + +++ + SL D + AL A + H EI E LL+ Sbjct: 13 FLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRV 72 Query: 69 KDDAGWSPLHIAASAGRDEIVKALLGKGA-------------------QVNAVNQNGC-- 107 D L +A S G IV+A+L A A +++G Sbjct: 73 GD-----ALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRF 127 Query: 108 ----TPLHYAASKNRHEIAVMLLEGGA 130 TP+ AA +EI LL GA Sbjct: 128 SHDVTPIILAAHCQEYEIVHTLLRKGA 154 Score = 39.6 bits (91), Expect = 0.001, Method: Composition-based stats. Identities = 30/115 (26%), Positives = 45/115 (39%), Gaps = 30/115 (26%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 LA + + E+ E +L ++L+ D AL A S G+ IVE +L K Sbjct: 47 ALQLAVANEHLEITELLLKKENLSRVGD-----ALLLAISKGYVRIVEAILNHPAFAEGK 101 Query: 70 -------------------DDAGW------SPLHIAASAGRDEIVKALLGKGAQV 99 D+ G +P+ +AA EIV LL KGA++ Sbjct: 102 RLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARI 156 >3LVQ-E nrPDB Length = 497 Score = 63.8 bits (154), Expect = 5e-11, Method: Composition-based stats. Identities = 28/105 (26%), Positives = 46/105 (43%), Gaps = 9/105 (8%) Query: 77 LHIAASAGR---DEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133 LH+A +V ++ G ++A +G T LHYAA N+ + +LL+G A Sbjct: 175 LHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVG 234 Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHL 178 + TA+ A K + + +L +A T PLH+ Sbjct: 235 TVNEAGETALDIARKKHHKECEELLEQAQAGTFA------FPLHV 273 Score = 63.1 bits (152), Expect = 9e-11, Method: Composition-based stats. Identities = 26/106 (24%), Positives = 42/106 (39%), Gaps = 9/106 (8%) Query: 109 PLHYA---ASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAST 165 LH A A++ + +++ G + DAK TA+H AA + +LL +A Sbjct: 174 VLHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALV 233 Query: 166 NIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV 211 + G T L +A + E +LL + PL V Sbjct: 234 GTVNEAGETALDIARKKHHKECEELLEQ------AQAGTFAFPLHV 273 Score = 63.1 bits (152), Expect = 9e-11, Method: Composition-based stats. Identities = 19/86 (22%), Positives = 38/86 (44%), Gaps = 3/86 (3%) Query: 143 MHRAAAKGN---LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199 +H A N L ++ ++ + + +GNT LH A + + KLL+ A + Sbjct: 175 LHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVG 234 Query: 200 IENKEEKTPLQVAKGGLGLILKRMVE 225 N+ +T L +A+ + ++E Sbjct: 235 TVNEAGETALDIARKKHHKECEELLE 260 Score = 59.6 bits (143), Expect = 1e-09, Method: Composition-based stats. Identities = 28/90 (31%), Positives = 43/90 (47%), Gaps = 3/90 (3%) Query: 44 LHWA---CSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN 100 LH A + +V+F++Q G ++ K G + LH AA + + +K LL A V Sbjct: 175 LHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVG 234 Query: 101 AVNQNGCTPLHYAASKNRHEIAVMLLEGGA 130 VN+ G T L A K+ E +L + A Sbjct: 235 TVNEAGETALDIARKKHHKECEELLEQAQA 264 Score = 51.5 bits (122), Expect = 3e-07, Method: Composition-based stats. Identities = 20/88 (22%), Positives = 35/88 (39%), Gaps = 1/88 (1%) Query: 5 VSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGV 64 + + +A L L + I+ + D TALH+A + ++ LL+ Sbjct: 173 LVLHLAVKVANQASL-PLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRA 231 Query: 65 PVNDKDDAGWSPLHIAASAGRDEIVKAL 92 V ++AG + L IA E + L Sbjct: 232 LVGTVNEAGETALDIARKKHHKECEELL 259 Score = 30.3 bits (67), Expect = 0.65, Method: Composition-based stats. Identities = 18/73 (24%), Positives = 27/73 (36%), Gaps = 7/73 (9%) Query: 7 NLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPV 66 N + A + + LK +L ++L ++ TAL A H E E L Q Sbjct: 208 NTALHYAALYNQPDCLK-LLLKGRALVGTVNEAGETALDIARKKHHKECEELLEQAQAGT 266 Query: 67 NDKDDAGWSPLHI 79 PLH+ Sbjct: 267 FAF------PLHV 273 >6CUD-A nrPDB Length = 806 Score = 62.7 bits (151), Expect = 1e-10, Method: Composition-based stats. Identities = 32/149 (21%), Positives = 54/149 (36%), Gaps = 32/149 (21%) Query: 77 LHIAASAGRDEIVKALL--GKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134 AA G +V+ +L K VN V+ G L A E+ +LL+ Sbjct: 31 FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARI 90 Query: 135 KDHYEATAMHRAAAKGNLKMIHILLYYKA-------------------STNIQDTEGN-- 173 D A+ A +KG ++++ +L + D +G Sbjct: 91 GD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRF 145 Query: 174 ----TPLHLACDEERVEEAKLLVSQGASI 198 TP+ LA ++ E +L+ +GA I Sbjct: 146 SPDITPIILAAHCQKYEVVHMLLMKGARI 174 Score = 52.3 bits (124), Expect = 2e-07, Method: Composition-based stats. Identities = 32/147 (21%), Positives = 52/147 (35%), Gaps = 31/147 (21%) Query: 10 VCNLAYSGKLEELKESIL-ADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVND 68 + A G + +++ + + D + AL A H E+ E LL+ Sbjct: 31 FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARI 90 Query: 69 KDDAGWSPLHIAASAGRDEIVKALLGKGA-------------------QVNAVNQNGC-- 107 D L +A S G IV+A+L A +++G Sbjct: 91 GD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRF 145 Query: 108 ----TPLHYAASKNRHEIAVMLLEGGA 130 TP+ AA ++E+ MLL GA Sbjct: 146 SPDITPIILAAHCQKYEVVHMLLMKGA 172 Score = 37.3 bits (85), Expect = 0.006, Method: Composition-based stats. Identities = 30/115 (26%), Positives = 45/115 (39%), Gaps = 30/115 (26%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 LA + E+ E +L ++LA D AL A S G+ IVE +L K Sbjct: 65 ALQLAVGNEHLEVTELLLKKENLARIGD-----ALLLAISKGYVRIVEAILNHPGFAASK 119 Query: 70 -------------------DDAGW------SPLHIAASAGRDEIVKALLGKGAQV 99 D+ G +P+ +AA + E+V LL KGA++ Sbjct: 120 RLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARI 174 >2B0O-E nrPDB Length = 301 Score = 61.9 bits (149), Expect = 2e-10, Method: Composition-based stats. Identities = 28/105 (26%), Positives = 46/105 (43%), Gaps = 9/105 (8%) Query: 77 LHIAASAGR---DEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133 LH+A +V ++ G ++A +G T LHYAA N+ + +LL+G A Sbjct: 194 LHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVG 253 Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHL 178 + TA+ A K + + +L +A T PLH+ Sbjct: 254 TVNEAGETALDIARKKHHKECEELLEQAQAGTFA------FPLHV 292 Score = 61.2 bits (147), Expect = 4e-10, Method: Composition-based stats. Identities = 19/86 (22%), Positives = 38/86 (44%), Gaps = 3/86 (3%) Query: 143 MHRAAAKGN---LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199 +H A N L ++ ++ + + +GNT LH A + + KLL+ A + Sbjct: 194 LHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVG 253 Query: 200 IENKEEKTPLQVAKGGLGLILKRMVE 225 N+ +T L +A+ + ++E Sbjct: 254 TVNEAGETALDIARKKHHKECEELLE 279 Score = 60.8 bits (146), Expect = 4e-10, Method: Composition-based stats. Identities = 26/106 (24%), Positives = 42/106 (39%), Gaps = 9/106 (8%) Query: 109 PLHYA---ASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAST 165 LH A A++ + +++ G + DAK TA+H AA + +LL +A Sbjct: 193 VLHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALV 252 Query: 166 NIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV 211 + G T L +A + E +LL + PL V Sbjct: 253 GTVNEAGETALDIARKKHHKECEELLEQ------AQAGTFAFPLHV 292 Score = 57.7 bits (138), Expect = 4e-09, Method: Composition-based stats. Identities = 28/90 (31%), Positives = 43/90 (47%), Gaps = 3/90 (3%) Query: 44 LHWA---CSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN 100 LH A + +V+F++Q G ++ K G + LH AA + + +K LL A V Sbjct: 194 LHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVG 253 Query: 101 AVNQNGCTPLHYAASKNRHEIAVMLLEGGA 130 VN+ G T L A K+ E +L + A Sbjct: 254 TVNEAGETALDIARKKHHKECEELLEQAQA 283 Score = 50.0 bits (118), Expect = 8e-07, Method: Composition-based stats. Identities = 20/88 (22%), Positives = 35/88 (39%), Gaps = 1/88 (1%) Query: 5 VSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGV 64 + + +A L L + I+ + D TALH+A + ++ LL+ Sbjct: 192 LVLHLAVKVANQASL-PLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRA 250 Query: 65 PVNDKDDAGWSPLHIAASAGRDEIVKAL 92 V ++AG + L IA E + L Sbjct: 251 LVGTVNEAGETALDIARKKHHKECEELL 278 Score = 29.2 bits (64), Expect = 1.5, Method: Composition-based stats. Identities = 18/73 (24%), Positives = 27/73 (36%), Gaps = 7/73 (9%) Query: 7 NLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPV 66 N + A + + LK +L ++L ++ TAL A H E E L Q Sbjct: 227 NTALHYAALYNQPDCLK-LLLKGRALVGTVNEAGETALDIARKKHHKECEELLEQAQAGT 285 Query: 67 NDKDDAGWSPLHI 79 PLH+ Sbjct: 286 FAF------PLHV 292 >6C8G-A nrPDB Length = 675 Score = 61.5 bits (148), Expect = 3e-10, Method: Composition-based stats. Identities = 17/91 (18%), Positives = 29/91 (31%), Gaps = 17/91 (18%) Query: 137 HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDT--------------EGNTPLHLACDE 182 + TA+H A + + +L+ A + Q G PL LA Sbjct: 101 YRGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACT 160 Query: 183 ERVEEAKLLVS---QGASIYIENKEEKTPLQ 210 + + L + A I ++ T L Sbjct: 161 NQPDIVHYLTENAHKKADIRRQDSRGNTVLH 191 Score = 61.2 bits (147), Expect = 3e-10, Method: Composition-based stats. Identities = 32/144 (22%), Positives = 50/144 (34%), Gaps = 33/144 (22%) Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD--------------HYEATAMHRAAAK 149 G T LH A + +L+E GA+ A+ ++ + AA Sbjct: 101 YRGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACT 160 Query: 150 GNLKMIHILLYY---KASTNIQDTEGNTPLH--LACDEERVEEAKLL-----------VS 193 ++H L KA QD+ GNT LH +A + E K + V Sbjct: 161 NQPDIVHYLTENAHKKADIRRQDSRGNTVLHALVAIADNTRENTKFVTKVYDLLVIKCVK 220 Query: 194 QGASIYIE---NKEEKTPLQVAKG 214 +E N + +PL +A Sbjct: 221 LYPDSSLEAIFNNDSMSPLMMAAK 244 Score = 56.5 bits (135), Expect = 9e-09, Method: Composition-based stats. Identities = 33/181 (18%), Positives = 61/181 (33%), Gaps = 36/181 (19%) Query: 16 SGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA--- 72 + K L+E I + +TALH A VE L++ G V+ + Sbjct: 82 AEKTGNLREFINSPFRDVY---YRGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFF 138 Query: 73 -----------GWSPLHIAASAGRDEIVKALLGKG---AQVNAVNQNGCTPLH--YAASK 116 G PL +AA + +IV L A + + G T LH A + Sbjct: 139 QPKDEGGYFYFGELPLSLAACTNQPDIVHYLTENAHKKADIRRQDSRGNTVLHALVAIAD 198 Query: 117 NRHE-----------IAVMLLEGGANPDAKDHYEA---TAMHRAAAKGNLKMIHILLYYK 162 N E + + ++ + + + + + AA G + + ++ + Sbjct: 199 NTRENTKFVTKVYDLLVIKCVKLYPDSSLEAIFNNDSMSPLMMAAKLGKIGIFQHIIRLE 258 Query: 163 A 163 Sbjct: 259 I 259 >6BBJ-A nrPDB Length = 868 Score = 61.5 bits (148), Expect = 3e-10, Method: Composition-based stats. Identities = 17/91 (18%), Positives = 29/91 (31%), Gaps = 17/91 (18%) Query: 137 HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDT--------------EGNTPLHLACDE 182 + TA+H A + + +L+ A + Q G PL LA Sbjct: 232 YRGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACT 291 Query: 183 ERVEEAKLLVS---QGASIYIENKEEKTPLQ 210 + + L + A I ++ T L Sbjct: 292 NQPDIVHYLTENAHKKADIRRQDSRGNTVLH 322 Score = 61.2 bits (147), Expect = 3e-10, Method: Composition-based stats. Identities = 32/144 (22%), Positives = 50/144 (34%), Gaps = 33/144 (22%) Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD--------------HYEATAMHRAAAK 149 G T LH A + +L+E GA+ A+ ++ + AA Sbjct: 232 YRGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACT 291 Query: 150 GNLKMIHILLYY---KASTNIQDTEGNTPLH--LACDEERVEEAKLL-----------VS 193 ++H L KA QD+ GNT LH +A + E K + V Sbjct: 292 NQPDIVHYLTENAHKKADIRRQDSRGNTVLHALVAIADNTRENTKFVTKVYDLLVIKCVK 351 Query: 194 QGASIYIE---NKEEKTPLQVAKG 214 +E N + +PL +A Sbjct: 352 LYPDSSLEAIFNNDSMSPLMMAAK 375 Score = 56.5 bits (135), Expect = 9e-09, Method: Composition-based stats. Identities = 33/181 (18%), Positives = 61/181 (33%), Gaps = 36/181 (19%) Query: 16 SGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA--- 72 + K L+E I + +TALH A VE L++ G V+ + Sbjct: 213 AEKTGNLREFINSPFRDVY---YRGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFF 269 Query: 73 -----------GWSPLHIAASAGRDEIVKALLGKG---AQVNAVNQNGCTPLH--YAASK 116 G PL +AA + +IV L A + + G T LH A + Sbjct: 270 QPKDEGGYFYFGELPLSLAACTNQPDIVHYLTENAHKKADIRRQDSRGNTVLHALVAIAD 329 Query: 117 NRHE-----------IAVMLLEGGANPDAKDHYEA---TAMHRAAAKGNLKMIHILLYYK 162 N E + + ++ + + + + + AA G + + ++ + Sbjct: 330 NTRENTKFVTKVYDLLVIKCVKLYPDSSLEAIFNNDSMSPLMMAAKLGKIGIFQHIIRLE 389 Query: 163 A 163 Sbjct: 390 I 390 >6MHW-A nrPDB Length = 826 Score = 60.0 bits (144), Expect = 8e-10, Method: Composition-based stats. Identities = 46/222 (20%), Positives = 78/222 (35%), Gaps = 45/222 (20%) Query: 14 AYSGKLEELKESILADKSLATRTDQDSRTALHWACSA---GHTEIVEFLLQL-------G 63 E++ + ++ +T L A EIV LL G Sbjct: 147 CRRRHDEDVPDFLMHK----LTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILG 202 Query: 64 VPVNDK----DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN-------------- 105 +N + G + L+IA + +I L+ GA VNA + Sbjct: 203 RFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYF 262 Query: 106 GCTPLHYAASKNRHEIAVMLLEGG-ANPDAKDHYEATAMHRAAAKGN---------LKMI 155 G TPL AA N+ EI +L+E + ++D +H +M Sbjct: 263 GETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMY 322 Query: 156 HILLYYKAS---TNIQDTEGNTPLHLACDEERVEEAKLLVSQ 194 ++L + ++ +G TPL LA + E K ++S+ Sbjct: 323 DMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSR 364 Score = 52.3 bits (124), Expect = 2e-07, Method: Composition-based stats. Identities = 35/178 (19%), Positives = 67/178 (37%), Gaps = 30/178 (16%) Query: 13 LAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA 72 LA++ + + L I A+ T + +TAL+ A +I L+ G VN Sbjct: 192 LAFAEENDILGRFINAEY---TEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKG 248 Query: 73 --------------GWSPLHIAASAGRDEIVKALLGKGA-QVNAVNQNGCTPLHYAA--- 114 G +PL +AA + EIV+ L+ + + + G LH Sbjct: 249 AFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVA 308 Query: 115 --SKNRHEIAV------MLLEGGANPD-AKDHYEATAMHRAAAKGNLKMIHILLYYKA 163 K +++ +L G + +++ T + AA G +++ +L + Sbjct: 309 EDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREI 366 Score = 50.8 bits (120), Expect = 5e-07, Method: Composition-based stats. Identities = 32/159 (20%), Positives = 48/159 (30%), Gaps = 32/159 (20%) Query: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASK---NRHEIAVMLLEG--------- 128 DE V L ++ A + G T L A N EI +LL Sbjct: 147 CRRRHDEDVPDFLMH--KLTASD-TGKTCLMKALLNINPNTKEIVRILLAFAEENDILGR 203 Query: 129 --GANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDT--------------EG 172 A + + TA++ A + + +L+ A N G Sbjct: 204 FINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFG 263 Query: 173 NTPLHLACDEERVEEAKLLVSQ-GASIYIENKEEKTPLQ 210 TPL LA + E +LL+ I + L Sbjct: 264 ETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILH 302 Score = 35.0 bits (79), Expect = 0.027, Method: Composition-based stats. Identities = 25/139 (17%), Positives = 47/139 (33%), Gaps = 31/139 (22%) Query: 114 ASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN---LKMIHILLYY-------KA 163 + E L T + +A N +++ ILL + Sbjct: 147 CRRRHDEDVPDFLMHKL---TASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGR 203 Query: 164 STNIQDTE----GNTPLHLACDEERVEEAKLLVSQGASIYIENK--------------EE 205 N + TE G T L++A + + + A LL++ GA + K Sbjct: 204 FINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFG 263 Query: 206 KTPLQVAKGGLGLILKRMV 224 +TPL +A + +++ Sbjct: 264 ETPLALAACTNQPEIVQLL 282 >4DX2-A nrPDB Length = 259 Score = 59.2 bits (142), Expect = 1e-09, Method: Composition-based stats. Identities = 51/230 (22%), Positives = 83/230 (36%), Gaps = 48/230 (20%) Query: 18 KLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPL 77 L+ L +L K TD++ R S G T + + LL L N ++D L Sbjct: 18 DLDGLLPFLLTHK--KRLTDEEFREP-----STGKTCLPKALLNLS---NGRNDTIPVLL 67 Query: 78 HIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD- 136 IA G + + + + G T LH A + +L+ GA+ A+ Sbjct: 68 DIAERTGNM---REFINSPFR--DIYYRGQTALHIAIERRCKHYVELLVAQGADVHAQAR 122 Query: 137 -------------HYEATAMHRAAAKGNLKMIHILLYY---KASTNIQDTEGNTPLH--L 178 ++ + AA +++ L KA QD+ GNT LH + Sbjct: 123 GRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALV 182 Query: 179 ACDEERVEEAK-------LLVSQGA----SIYIE---NKEEKTPLQVAKG 214 A + E K LL+ + A +E N + +PL +A Sbjct: 183 AIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAAK 232 Score = 54.6 bits (130), Expect = 3e-08, Method: Composition-based stats. Identities = 31/158 (19%), Positives = 54/158 (34%), Gaps = 33/158 (20%) Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA--------------GWSPLHIAASA 83 +TALH A VE L+ G V+ + G PL +AA Sbjct: 89 YRGQTALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACT 148 Query: 84 GRDEIVKALLGKG---AQVNAVNQNGCTPLH--YAASKNRHEIAV--------MLLEGG- 129 + IV L A + + G T LH A + N E +LL+ Sbjct: 149 NQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCAR 208 Query: 130 --ANPDAK---DHYEATAMHRAAAKGNLKMIHILLYYK 162 + + + ++ + + AA G + + ++ + Sbjct: 209 LFPDSNLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRRE 246 >6DJS-A nrPDB Length = 676 Score = 59.2 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 32/147 (21%), Positives = 54/147 (36%), Gaps = 32/147 (21%) Query: 79 IAASAGRDEIVKALL--GKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136 AA G +V+ +L K VN V+ G L A E+ +LL+ D Sbjct: 50 DAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGD 109 Query: 137 HYEATAMHRAAAKGNLKMIHILLYYKA-------------------STNIQDTEGN---- 173 A+ A +KG ++++ +L + D +G Sbjct: 110 -----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSP 164 Query: 174 --TPLHLACDEERVEEAKLLVSQGASI 198 TP+ LA ++ E +L+ +GA I Sbjct: 165 DITPIILAAHCQKYEVVHMLLMKGARI 191 Score = 49.2 bits (116), Expect = 1e-06, Method: Composition-based stats. Identities = 32/147 (21%), Positives = 52/147 (35%), Gaps = 31/147 (21%) Query: 10 VCNLAYSGKLEELKESIL-ADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVND 68 + A G + +++ + + D + AL A H E+ E LL+ Sbjct: 48 FLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARI 107 Query: 69 KDDAGWSPLHIAASAGRDEIVKALLGKGA-------------------QVNAVNQNGC-- 107 D L +A S G IV+A+L A +++G Sbjct: 108 GD-----ALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRF 162 Query: 108 ----TPLHYAASKNRHEIAVMLLEGGA 130 TP+ AA ++E+ MLL GA Sbjct: 163 SPDITPIILAAHCQKYEVVHMLLMKGA 189 Score = 35.0 bits (79), Expect = 0.030, Method: Composition-based stats. Identities = 30/115 (26%), Positives = 45/115 (39%), Gaps = 30/115 (26%) Query: 10 VCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDK 69 LA + E+ E +L ++LA D AL A S G+ IVE +L K Sbjct: 82 ALQLAVGNEHLEVTELLLKKENLARIGD-----ALLLAISKGYVRIVEAILNHPGFAASK 136 Query: 70 -------------------DDAGW------SPLHIAASAGRDEIVKALLGKGAQV 99 D+ G +P+ +AA + E+V LL KGA++ Sbjct: 137 RLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARI 191 >3W9G-A nrPDB Length = 260 Score = 58.8 bits (141), Expect = 2e-09, Method: Composition-based stats. Identities = 17/91 (18%), Positives = 28/91 (30%), Gaps = 17/91 (18%) Query: 137 HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDT--------------EGNTPLHLACDE 182 + TA+H A + + +L+ A + Q G PL LA Sbjct: 91 YRGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACT 150 Query: 183 ERVEEAKLLVSQG---ASIYIENKEEKTPLQ 210 + L G A + ++ T L Sbjct: 151 NQPHIVHYLTENGHKQADLRRQDSRGNTVLH 181 Score = 56.9 bits (136), Expect = 6e-09, Method: Composition-based stats. Identities = 31/159 (19%), Positives = 56/159 (35%), Gaps = 33/159 (20%) Query: 38 QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA--------------GWSPLHIAASA 83 +TALH A VE L++ G V+ + G PL +AA Sbjct: 91 YRGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACT 150 Query: 84 GRDEIVKALLGKG---AQVNAVNQNGCTPLH--YAASKNRHEIAV--------MLLEGG- 129 + IV L G A + + G T LH A + N E +L++ Sbjct: 151 NQPHIVHYLTENGHKQADLRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLIKCAK 210 Query: 130 --ANPDAK---DHYEATAMHRAAAKGNLKMIHILLYYKA 163 + + + ++ + + AA G + + ++ + Sbjct: 211 LFPDTNLEALLNNDGLSPLMMAAKTGKIGIFQHIIRREI 249 Score = 40.7 bits (94), Expect = 5e-04, Method: Composition-based stats. Identities = 13/57 (22%), Positives = 23/57 (40%), Gaps = 14/57 (24%) Query: 171 EGNTPLHLACDEERVEEAKLLVSQGASIYIENK--------------EEKTPLQVAK 213 G T LH+A + +LLV +GA ++ + + + PL +A Sbjct: 92 RGQTALHIAIERRCKHYVELLVEKGADVHAQARGRFFQPKDEGGYFYFGELPLSLAA 148 >6G1K-A nrPDB Length = 921 Score = 58.5 bits (140), Expect = 3e-09, Method: Composition-based stats. Identities = 32/137 (23%), Positives = 51/137 (37%), Gaps = 25/137 (18%) Query: 80 AASAGRDEIVKALLGKGA-----QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134 A G VK L + +N ++ G T L A EI +LL Sbjct: 39 AVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAIENENLEIIELLLSF------ 92 Query: 135 KDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQ-------DTEGN------TPLHLACD 181 + Y A+ A K + + +LL +K + + D + + TP+ LA Sbjct: 93 -NVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSDFTPDITPIILAAH 151 Query: 182 EERVEEAKLLVSQGASI 198 E K+LV +G S+ Sbjct: 152 TNNYEIIKMLVQKGVSV 168 Score = 46.1 bits (108), Expect = 1e-05, Method: Composition-based stats. Identities = 32/140 (22%), Positives = 47/140 (33%), Gaps = 24/140 (17%) Query: 10 VCNLAYSGKLEELKESILADKS----LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP 65 + G +K ++ + D RTAL A + EI+E LL V Sbjct: 36 YLSAVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAIENENLEIIELLLSFNVY 95 Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKG------------AQVNAVNQN-GCTPLHY 112 V G + LH A V+ LL + TP+ Sbjct: 96 V------GDALLH-AIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSDFTPDITPIIL 148 Query: 113 AASKNRHEIAVMLLEGGANP 132 AA N +EI ML++ G + Sbjct: 149 AAHTNNYEIIKMLVQKGVSV 168 >4CJ9-A nrPDB Length = 794 Score = 43.8 bits (102), Expect = 6e-05, Method: Composition-based stats. Identities = 29/180 (16%), Positives = 70/180 (38%), Gaps = 7/180 (3%) Query: 46 WACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN 105 A + G + ++ +L+ +N++ + + IA + G + +KA+L A ++ + Sbjct: 585 VAGNNGGAQALKAVLEHEATLNERGFSRADIVKIAGNGGGAQALKAVLEHEATLDERGFS 644 Query: 106 GCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAST 165 + A + + +LE G + + + AA G + + +L + + Sbjct: 645 RADIVRIAGNGGGAQALKAVLEHGPTLNERGFNLTDIVEMAANSGGAQALKAVLEHGPTL 704 Query: 166 NIQDTEGNTPLHLA--CDEERVEEAKLLVSQGASIYIENKEEKTPLQVA--KGGLGLILK 221 G + + + + K ++ G + + + + VA +GG G I K Sbjct: 705 R---QRGLSLIDIVEIASNGGAQALKAVLKYGPVLMQAGRSNEEIVHVAARRGGAGRIRK 761 Score = 34.2 bits (77), Expect = 0.050, Method: Composition-based stats. Identities = 22/148 (14%), Positives = 54/148 (36%), Gaps = 1/148 (0%) Query: 79 IAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHY 138 IA + G + + A+L + + ++ A + + +LE A + + Sbjct: 552 IAGNDGGTQALHAVLDLERMLGERGFSRADIVNVAGNNGGAQALKAVLEHEATLNERGFS 611 Query: 139 EATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASI 198 A + A G + + +L ++A+ + + + +A + + K ++ G ++ Sbjct: 612 RADIVKIAGNGGGAQALKAVLEHEATLDERGFSRADIVRIAGNGGGAQALKAVLEHGPTL 671 Query: 199 YIEN-KEEKTPLQVAKGGLGLILKRMVE 225 A G LK ++E Sbjct: 672 NERGFNLTDIVEMAANSGGAQALKAVLE 699 >5Z96-A nrPDB Length = 755 Score = 43.4 bits (101), Expect = 7e-05, Method: Composition-based stats. Identities = 32/137 (23%), Positives = 51/137 (37%), Gaps = 25/137 (18%) Query: 80 AASAGRDEIVKALLGKGA-----QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134 A G VK L + +N ++ G T L A E+ +LL Sbjct: 39 AVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSF------ 92 Query: 135 KDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQ-------DTEGN------TPLHLACD 181 + Y A+ A K + + +LL +K + + D + + TP+ LA Sbjct: 93 -NVYVGDALLHAIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAH 151 Query: 182 EERVEEAKLLVSQGASI 198 E KLLV +G S+ Sbjct: 152 TNNYEIIKLLVQKGVSV 168 Score = 31.9 bits (71), Expect = 0.22, Method: Composition-based stats. Identities = 32/140 (22%), Positives = 49/140 (35%), Gaps = 24/140 (17%) Query: 10 VCNLAYSGKLEELKESILADKS----LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP 65 N G +K+S+ + D RTAL A + E++E LL V Sbjct: 36 YLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVY 95 Query: 66 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAV-------NQN------GCTPLHY 112 V G + LH A V+ LL ++ TP+ Sbjct: 96 V------GDALLH-AIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIIL 148 Query: 113 AASKNRHEIAVMLLEGGANP 132 AA N +EI +L++ G + Sbjct: 149 AAHTNNYEIIKLLVQKGVSV 168 >6BWI-A nrPDB Length = 977 Score = 36.5 bits (83), Expect = 0.010, Method: Composition-based stats. Identities = 15/71 (21%), Positives = 28/71 (39%), Gaps = 5/71 (7%) Query: 143 MHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIEN 202 + A A + + L+ + L A +R E +LL+S G S+ Sbjct: 198 LRLAVAWNRVDIAQSELFRG-DIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSL---- 252 Query: 203 KEEKTPLQVAK 213 TP+++A+ Sbjct: 253 GHFLTPMRLAQ 263 Score = 29.6 bits (65), Expect = 1.2, Method: Composition-based stats. Identities = 15/70 (21%), Positives = 28/70 (40%), Gaps = 5/70 (7%) Query: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136 L +A + R +I ++ L +G + + + L A +R E +L+ G + Sbjct: 198 LRLAVAWNRVDIAQSELFRG-DIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHF- 255 Query: 137 HYEATAMHRA 146 T M A Sbjct: 256 ---LTPMRLA 262 >1EV4-A nrPDB Length = 221 Score = 29.6 bits (65), Expect = 1.1, Method: Composition-based stats. Identities = 10/43 (23%), Positives = 19/43 (44%), Gaps = 1/43 (2%) Query: 171 EGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213 G LH R+E + L++ A + + K ++P + K Sbjct: 1 SGKPVLHYFNARGRMECIRFLLAA-AGVEFDEKFIQSPEDLEK 42 >2DI3-A nrPDB Length = 239 Score = 29.2 bits (64), Expect = 1.7, Method: Composition-based stats. Identities = 16/60 (26%), Positives = 25/60 (41%), Gaps = 4/60 (6%) Query: 105 NGCTPLHYAASKNRHEIAVMLLEGGANPD--AKDHYEATA-MHRAAAKGNLK-MIHILLY 160 G LH +A + ++A LLE +P +D A H +KG +I L+ Sbjct: 106 EGWAALHSSAERGDWDVAEALLEKMDDPSLPLEDFLRFDAEFHVVISKGAENPLISTLME 165 >6GC1-A nrPDB Length = 579 Score = 27.6 bits (60), Expect = 4.8, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 20/44 (45%), Gaps = 1/44 (2%) Query: 110 LHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLK 153 + + A H+I +LL+ G P + + T + A GN + Sbjct: 362 ILWIAMAGTHQIWALLLDSGKLPKKNELTKGTCLRFAG-SGNEE 404 >3WQO-A nrPDB Length = 293 Score = 27.3 bits (59), Expect = 6.3, Method: Composition-based stats. Identities = 17/73 (23%), Positives = 29/73 (39%), Gaps = 4/73 (5%) Query: 57 EFLLQLGVPVNDKDDAGWSPLHIAASAGRD-EIVKALLGKGA---QVNAVNQNGCTPLHY 112 E LL++ ++ K+ + A +AG E V+ L G V+A + NG H Sbjct: 173 ESLLEIVKDIDSKNLGITFDIGHANTAGNPAEFVEKLQNIGIGIIHVHAHDNNGYDDEHL 232 Query: 113 AASKNRHEIAVML 125 + +L Sbjct: 233 KIGEGNINFIEVL 245 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.142 0.375 Lambda K H 0.267 0.0432 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 8,167,459 Number of Sequences: 36641 Number of extensions: 306607 Number of successful extensions: 2145 Number of sequences better than 10.0: 85 Number of HSP's better than 10.0 without gapping: 137 Number of HSP's successfully gapped in prelim test: 25 Number of HSP's that attempted gapping in prelim test: 618 Number of HSP's gapped (non-prelim): 601 length of query: 226 length of database: 10,336,785 effective HSP length: 94 effective length of query: 132 effective length of database: 6,892,531 effective search space: 909814092 effective search space used: 909814092 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.8 bits) S2: 57 (26.5 bits)