BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= O75828 (277 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2HRB-A nrPDB 565 e-161 3BHI-A nrPDB 421 e-118 1N5D-A nrPDB 405 e-113 3O26-A nrPDB 125 1e-29 5L51-A nrPDB 120 9e-28 5LCX-A nrPDB 110 7e-25 3FTP-A nrPDB 77 8e-15 3U5T-A nrPDB 74 9e-14 5YSS-A nrPDB 71 6e-13 3W8F-A nrPDB 64 6e-11 4BO1-A nrPDB 64 8e-11 2Q2Q-A nrPDB 63 1e-10 3RSH-A nrPDB 62 2e-10 1Q7C-A nrPDB 60 7e-10 1X1T-A nrPDB 60 1e-09 2C07-A nrPDB 60 1e-09 3OSU-A nrPDB 60 1e-09 4DBZ-A nrPDB 59 2e-09 5U9P-A nrPDB 59 3e-09 3RKU-A nrPDB 59 3e-09 2UVD-A nrPDB 57 7e-09 3LYL-A nrPDB 57 8e-09 6NRP-A nrPDB 56 2e-08 3V2G-A nrPDB 56 2e-08 2PNF-A nrPDB 56 2e-08 1YXM-A nrPDB 55 2e-08 3O4R-A nrPDB 54 5e-08 5CDY-A nrPDB 53 1e-07 2ZAT-A nrPDB 53 2e-07 5OJG-A nrPDB 52 3e-07 1GEG-A nrPDB 52 3e-07 4IIV-A nrPDB 52 3e-07 3EMK-A nrPDB 52 3e-07 3OEC-A nrPDB 52 3e-07 3V2H-A nrPDB 52 3e-07 3WOH-A nrPDB 52 3e-07 2CFC-A nrPDB 52 4e-07 3VZS-A nrPDB 51 5e-07 4DMM-A nrPDB 51 5e-07 5ITV-A nrPDB 51 6e-07 3KZV-A nrPDB 51 6e-07 2HSD-A nrPDB 50 8e-07 3WTC-A nrPDB 50 1e-06 3WYE-A nrPDB 50 1e-06 3OIC-A nrPDB 50 1e-06 2NWQ-A nrPDB 49 2e-06 2CDH-G nrPDB 49 3e-06 3GRP-A nrPDB 48 4e-06 2HQ1-A nrPDB 47 7e-06 3RWB-A nrPDB 47 8e-06 4HP8-A nrPDB 47 1e-05 4MOW-A nrPDB 47 1e-05 3V8B-A nrPDB 46 2e-05 4K6F-A nrPDB 46 2e-05 3F9I-A nrPDB 45 3e-05 4CQM-B nrPDB 45 3e-05 1AE1-A nrPDB 45 3e-05 4NBT-A nrPDB 45 4e-05 5T5Q-A nrPDB 45 4e-05 2GDZ-A nrPDB 45 5e-05 1UZM-A nrPDB 44 5e-05 1DOH-A nrPDB 44 6e-05 4IIN-A nrPDB 44 6e-05 1AHH-A nrPDB 44 7e-05 4KMS-A nrPDB 44 7e-05 2NM0-A nrPDB 44 7e-05 6CI9-A nrPDB 44 7e-05 4Z9Y-A nrPDB 44 1e-04 2AE2-A nrPDB 44 1e-04 3EZL-A nrPDB 43 1e-04 3R3S-A nrPDB 43 1e-04 4M8S-A nrPDB 43 1e-04 1HXH-A nrPDB 43 1e-04 2B4Q-A nrPDB 43 2e-04 4E6P-A nrPDB 43 2e-04 1NFF-A nrPDB 43 2e-04 4RZH-A nrPDB 43 2e-04 4NBV-A nrPDB 43 2e-04 4AVY-A nrPDB 42 2e-04 4DA9-A nrPDB 42 2e-04 3T7C-A nrPDB 42 3e-04 4JRO-A nrPDB 42 3e-04 3A28-C nrPDB 42 4e-04 5VT6-A nrPDB 41 6e-04 6CGE-A nrPDB 41 6e-04 1A27-A nrPDB 40 8e-04 3AUT-A nrPDB 40 0.001 2PH3-A nrPDB 40 0.001 3UF0-A nrPDB 38 0.004 5PGZ-A nrPDB 38 0.004 4EGF-A nrPDB 38 0.006 3D3W-A nrPDB 38 0.006 5OVL-A nrPDB 37 0.006 5OVJ-A nrPDB 37 0.007 2EW8-A nrPDB 37 0.009 1SNY-A nrPDB 37 0.011 4FC7-A nrPDB 36 0.014 4HBG-A nrPDB 36 0.015 5ILO-A nrPDB 36 0.016 5JY1-A nrPDB 36 0.020 1K2W-A nrPDB 35 0.029 1CYD-A nrPDB 35 0.031 4IS3-A nrPDB 35 0.043 5TQV-A nrPDB 35 0.045 4RZI-B nrPDB 34 0.088 2O23-A nrPDB 33 0.090 3UN1-A nrPDB 33 0.12 1OAA-A nrPDB 33 0.13 1GEE-A nrPDB 33 0.15 3U4C-A nrPDB 33 0.16 1E3W-A nrPDB 32 0.22 1H5Q-A nrPDB 32 0.28 5KOI-A nrPDB 31 0.57 3DWF-A nrPDB 31 0.75 1O5I-A nrPDB 30 0.79 5B1Y-A nrPDB 30 1.2 4TRR-A nrPDB 30 1.2 2EBZ-A nrPDB 30 1.6 3CGZ-A nrPDB 30 1.7 1ID0-A nrPDB 29 2.1 4CQL-A nrPDB 29 2.2 3U9L-A nrPDB 29 2.3 3E9N-A nrPDB 29 2.5 3OML-A nrPDB 28 3.2 1CZN-A nrPDB 28 4.1 4MDP-A nrPDB 28 4.2 4DRY-A nrPDB 28 5.7 >2HRB-A nrPDB Length = 274 Score = 565 bits (1455), Expect = e-161, Method: Compositional matrix adjust. Identities = 273/273 (100%), Positives = 273/273 (100%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI Sbjct: 2 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 61 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE 124 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE Sbjct: 62 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE 121 Query: 125 LLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVH 184 LLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVH Sbjct: 122 LLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVH 181 Query: 185 EREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTV 244 EREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTV Sbjct: 182 EREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTV 241 Query: 245 EEGAETPVYLALLPPDATEPQGQLVHDKVVQNW 277 EEGAETPVYLALLPPDATEPQGQLVHDKVVQNW Sbjct: 242 EEGAETPVYLALLPPDATEPQGQLVHDKVVQNW 274 >3BHI-A nrPDB Length = 276 Score = 421 bits (1083), Expect = e-118, Method: Compositional matrix adjust. Identities = 198/276 (71%), Positives = 234/276 (84%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 SS VALVTG N+GIGLAI R+LCR FSGDVVLTARDV RGQAAVQQLQAEGLSPRFHQ Sbjct: 1 SSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQ 60 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 LDIDDLQSIRALRDFLRKEYGGL+VLVNNA +AFK DP PF I+AE+T+KTNFF TR++ Sbjct: 61 LDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDV 120 Query: 122 CNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKN 181 C ELLP++KP GRVVN+SS+ +RA ++CS +LQ++F SET+TE +LV LM KFVEDTK Sbjct: 121 CTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKK 180 Query: 182 EVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSI 241 VH++EGWP+S YGV+K+GVTVLSRI AR+L E+RK D+IL+NACCPG V+TDM G + Sbjct: 181 GVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKAT 240 Query: 242 RTVEEGAETPVYLALLPPDATEPQGQLVHDKVVQNW 277 ++ EEGAETPVYLALLPPDA P GQ V +K V+ W Sbjct: 241 KSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW 276 >1N5D-A nrPDB Length = 288 Score = 405 bits (1041), Expect = e-113, Method: Compositional matrix adjust. Identities = 194/276 (70%), Positives = 230/276 (83%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 SS +RVALVTGAN+GIG AI R+LCRQF+GDVVLTARDVARGQAAV+QLQAEGLSPRFHQ Sbjct: 1 SSNTRVALVTGANKGIGFAIVRDLCRQFAGDVVLTARDVARGQAAVKQLQAEGLSPRFHQ 60 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 LDI DLQSIRAL DFLRKEYGGL+VLVNNAA+AF+ D+P PF I+AE+T+KTNF TRN+ Sbjct: 61 LDIIDLQSIRALCDFLRKEYGGLDVLVNNAAIAFQLDNPTPFHIQAELTMKTNFMGTRNV 120 Query: 122 CNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKN 181 C ELLP++KP GRVVN+SS + +RA CS +LQ++F SET+TE +LV LM KFVEDTKN Sbjct: 121 CTELLPLIKPQGRVVNVSSTEGVRALNECSPELQQKFKSETITEEELVGLMNKFVEDTKN 180 Query: 182 EVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSI 241 VH +EGW +S YGV+K+GV+VLSRI AR+L E+R D+IL+NACCPG V+TDM G + Sbjct: 181 GVHRKEGWSDSTYGVTKIGVSVLSRIYARKLREQRAGDKILLNACCPGWVRTDMGGPKAP 240 Query: 242 RTVEEGAETPVYLALLPPDATEPQGQLVHDKVVQNW 277 ++ E GAETPVYLALLP DA P GQ V DK V W Sbjct: 241 KSPEVGAETPVYLALLPSDAEGPHGQFVTDKKVVEW 276 >3O26-A nrPDB Length = 311 Score = 125 bits (315), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 97/300 (32%), Positives = 149/300 (49%), Gaps = 51/300 (17%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGD---VVLTARDVARGQAAVQQLQ-AEGLSPRFHQ 61 R A+VTG N+GIG E+C+Q S + VVLT RDV +G AV++L+ + + FHQ Sbjct: 13 RCAVVTGGNKGIGF----EICKQLSSNGIMVVLTCRDVTKGHEAVEKLKNSNHENVVFHQ 68 Query: 62 LDIDD-LQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDD-----PMPFDIK--------- 106 LD+ D + ++ +L DF++ +G L++LVNNA VA S D M DI Sbjct: 69 LDVTDPIATMSSLADFIKTHFGKLDILVNNAGVAGFSVDADRFKAMISDIGEDSEELVKI 128 Query: 107 ----------------AEMTLKTNFFATRNMCNELLPIMK--PHGRVVNISSLQCLRAFE 148 AE LK N+ +++ L+P+++ R+VN+SS + Sbjct: 129 YEKPEAQELMSETYELAEECLKINYNGVKSVTEVLIPLLQLSDSPRIVNVSSSTGSLKYV 188 Query: 149 NCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPN--SPYGVSKLGVTVLSR 206 + L+ + LTE + ++ ++D K + E GWP+ + Y SK + +R Sbjct: 189 SNETALEILGDGDALTEERIDMVVNMLLKDFKENLIETNGWPSFGAAYTTSKACLNAYTR 248 Query: 207 ILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTVEEGAETPVYLALLPPDATEPQG 266 +LA ++ + VN CPG VKT+M+ T EEGAE V +AL P D P G Sbjct: 249 VLANKI------PKFQVNCVCPGLVKTEMNYGIGNYTAEEGAEHVVRIALFPDDG--PSG 300 >5L51-A nrPDB Length = 324 Score = 120 bits (300), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 95/305 (31%), Positives = 150/305 (49%), Gaps = 60/305 (19%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGD---VVLTARDVARGQAAVQQLQAEGLSPR 58 ++ R A+VTGAN+GIG E+C+Q + V+L +RD RG A ++L E L Sbjct: 12 AATKRYAVVTGANKGIGF----EICKQLASKGITVILASRDEKRGIEARERLIKE-LGSE 66 Query: 59 F------HQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAV------------------- 93 F QLD+ D S+ AL DF++ ++G L++LVNNA + Sbjct: 67 FGDYVVSQQLDVADPASVAALVDFIKTKFGSLDILVNNAGLNGTYMEGDASVLNDYVEAE 126 Query: 94 --AFKSDDPM--PFDIKA-----------EMTLKTNFFATRNMCNELLPIMKPHG--RVV 136 F+S P+ KA + ++TN++ ++ + L+P+++ R+V Sbjct: 127 FKTFQSGAAKTEPYHPKATGRLVETVEHAKECIETNYYGSKRVTEALIPLLQQSDSPRIV 186 Query: 137 NISSLQCLRAFENCSEDLQERFHSET-LTEGDLVDLMKKFVEDTKNEVHEREGWPN--SP 193 N+SS F+ +E + F SE LTE L +++ +F++D + + + WP S Sbjct: 187 NVSSTLSSLVFQT-NEWAKGVFSSEEGLTEEKLEEVLAEFLKDFIDGKQQEKQWPPHFSA 245 Query: 194 YGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTVEEGAETPVY 253 Y VSK + +RI+A++ R +NA CPG KTD+ T E AE PV Sbjct: 246 YKVSKAALNAYTRIIAKKYPSFR------INAVCPGYTKTDLSYGHGQFTDAEAAEAPVK 299 Query: 254 LALLP 258 LALLP Sbjct: 300 LALLP 304 >5LCX-A nrPDB Length = 316 Score = 110 bits (275), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 98/307 (31%), Positives = 148/307 (48%), Gaps = 60/307 (19%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGD---VVLTARDVARGQAAVQQLQAE-GLS 56 M+ R ALVTGAN+GIG E+CRQ + V+LT+R+ RG A Q+L E +S Sbjct: 3 MAEVQRYALVTGANKGIGF----EICRQLAEKGIIVILTSRNEKRGLEARQKLLKELNVS 58 Query: 57 PR---FHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVA------------------F 95 FHQLD+ DL S+ A+ F++ ++G L++LVNNA V+ F Sbjct: 59 ENRLVFHQLDVTDLASVAAVAVFIKSKFGKLDILVNNAGVSGVEMVGDVSVFNEYIEADF 118 Query: 96 KS---------DDPMPFDIKA--EMTLK---------TNFFATRNMCNELLPIMK--PHG 133 K+ ++P PF KA EM K TN++ + + L+P+++ P Sbjct: 119 KALQALEAGAKEEP-PFKPKANGEMIEKFEGAKDCVVTNYYGPKRLTQALIPLLQLSPSP 177 Query: 134 RVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPN-- 191 R+VN+SS + LTE + ++++ F++D K E WP Sbjct: 178 RIVNVSSSFGSLLLLWNEWAKGVLGDEDRLTEERVDEVVEVFLKDIKEGKLEESQWPPHF 237 Query: 192 SPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTVEEGAETP 251 + VSK + ++I A++ R +NA CPG KTD+ +V E A+ P Sbjct: 238 AAERVSKAALNAYTKIAAKKYPSFR------INAICPGYAKTDITFHAGPLSVAEAAQVP 291 Query: 252 VYLALLP 258 V LALLP Sbjct: 292 VKLALLP 298 >3FTP-A nrPDB Length = 270 Score = 77.0 bits (188), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 72/236 (30%), Positives = 104/236 (44%), Gaps = 56/236 (23%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 +VA+VTGA+RGIG AIA EL R+ + V+ TA A + + GL R L+++ Sbjct: 29 QVAIVTGASRGIGRAIALELARRGA-MVIGTATTEAGAEGIGAAFKQAGLEGRGAVLNVN 87 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKA---EMTLKTNFFATRNMC 122 D ++ AL + KE+G LNVLVNNA + + D + +K + + TN A + Sbjct: 88 DATAVDALVESTLKEFGALNVLVNNAGI---TQDQLAMRMKDDEWDAVIDTNLKAVFRLS 144 Query: 123 NELL-PIMKPH-GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 +L P+MK GR+VNI+S Sbjct: 145 RAVLRPMMKARGGRIVNITS---------------------------------------- 164 Query: 181 NEVHEREGWPNS-PYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 V G P Y +K GV ++R LAR + + I VN PG + TDM Sbjct: 165 --VVGSAGNPGQVNYAAAKAGVAGMTRALAREIGSR----GITVNCVAPGFIDTDM 214 >3U5T-A nrPDB Length = 267 Score = 73.6 bits (179), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 69/252 (27%), Positives = 104/252 (41%), Gaps = 62/252 (24%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M ++VA+VTGA+RGIG AIA L V+ A A + +++A G Sbjct: 23 MMETNKVAIVTGASRGIGAAIAARLASDGFTVVINYAGKAAAAEEVAGKIEAAGGKALTA 82 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEM-------TLKT 113 Q D+ D ++R L + +GG++VLVNNA + MP AE + Sbjct: 83 QADVSDPAAVRRLFATAEEAFGGVDVLVNNAGI-------MPLTTIAETGDAVFDRVIAV 135 Query: 114 NFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMK 173 N T N E ++ GR++N+S+ Q V L+ Sbjct: 136 NLKGTFNTLREAAQRLRVGGRIINMSTSQ--------------------------VGLL- 168 Query: 174 KFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKT 233 H G Y +K GV ++ +L++ L + I VNA PGP T Sbjct: 169 ----------HPSYGI----YAAAKAGVEAMTHVLSKEL----RGRDITVNAVAPGPTAT 210 Query: 234 D--MDGK-DSIR 242 D ++GK D +R Sbjct: 211 DLFLEGKSDEVR 222 >5YSS-A nrPDB Length = 256 Score = 70.9 bits (172), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 65/252 (25%), Positives = 104/252 (41%), Gaps = 52/252 (20%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M+ + ALVTG+ GIGL IA+ L + + ++ DV + AV Q G +P +H Sbjct: 1 MNLTGKTALVTGSTSGIGLGIAQVLAQAGATLILNGFGDVDAAKDAVAQY---GKTPGYH 57 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSD-DPMPFDIKAEMTLKTNFFATR 119 D+ D I + + E+GG+++L+NNA + S + P D K + N + Sbjct: 58 GADLSDEAQIADMMRYAESEFGGVDILINNAGIQHVSPIETFPVD-KWNAIIAINLSSVF 116 Query: 120 NMCNELLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 + LP M+ GR++NI+S+ L A + Sbjct: 117 HTTRLALPGMRARNWGRIINIASVHGLVASKE---------------------------- 148 Query: 178 DTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDG 237 S Y +K GV L++ +A + I NA CPG V T + Sbjct: 149 -------------KSAYVAAKHGVVGLTKTIALETAQT----EITCNALCPGWVLTPLVQ 191 Query: 238 KDSIRTVEEGAE 249 + + + EGAE Sbjct: 192 QQIDKRIAEGAE 203 >3W8F-A nrPDB Length = 260 Score = 64.3 bits (155), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 68/238 (28%), Positives = 100/238 (42%), Gaps = 62/238 (26%) Query: 8 ALVTGANRGIGLAIARELCRQFSGDVVLTA----RDVARGQAAVQQLQAEGLSPRFHQLD 63 A+VTG+ GIGLA+A EL + DVV+ D+ R ++ ++ G+ + D Sbjct: 7 AVVTGSTSGIGLAMATELAKA-GADVVINGFGQPEDIERERSTLES--KFGVKAYYLNAD 63 Query: 64 IDDLQSIRALRDFLRKE---YGGLNVLVNNAAVAFKSD-DPMPFDIKAEMTLKTNFFATR 119 + D Q A RDF+ K GGL++LVNNA + + + P D K + N A Sbjct: 64 LSDAQ---ATRDFIAKAAEALGGLDILVNNAGIQHTAPIEEFPVD-KWNAIIALNLSAVF 119 Query: 120 NMCNELLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 + LPIM+ GR++NI+S L A N Sbjct: 120 HGTAAALPIMQKQGWGRIINIASAHGLVASVN---------------------------- 151 Query: 178 DTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 S Y +K GV L+++ A L+ K I NA CPG V+T + Sbjct: 152 -------------KSAYVAAKHGVVGLTKVTA--LENAGKG--ITCNAICPGWVRTPL 192 >4BO1-A nrPDB Length = 269 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 64/242 (26%), Positives = 100/242 (41%), Gaps = 58/242 (23%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 MS +VALVTGA+RGIG AIA EL R V+ TA + + + L+A G+ Sbjct: 23 MSLQGKVALVTGASRGIGQAIALELGR-LGAVVIGTATSASGAEKIAETLKANGVEGAGL 81 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVA-----FKSDDPMPFDIKAEMTLKTNF 115 LD+ +S+ A + +++ G ++VNNA + + D FD+ + TN Sbjct: 82 VLDVSSDESVAATLEHIQQHLGQPLIVVNNAGITRDNLLVRMKDDEWFDV-----VNTNL 136 Query: 116 FATRNMCNELLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMK 173 + + +L M GR++NI S+ + A N + Sbjct: 137 NSLYRLSKAVLRGMTKARWGRIINIGSV--VGAMGNAGQ--------------------- 173 Query: 174 KFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKT 233 + Y +K G+ +R LAR + + I VNA PG + T Sbjct: 174 ------------------TNYAAAKAGLEGFTRALAREVGSR----AITVNAVAPGFIDT 211 Query: 234 DM 235 DM Sbjct: 212 DM 213 >2Q2Q-A nrPDB Length = 255 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 49/146 (33%), Positives = 73/146 (50%), Gaps = 13/146 (8%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 + ALVTG+ GIGL IA+ L R + V+ D A A+ ++ G+ H D+ Sbjct: 4 GKTALVTGSTSGIGLGIAQVLARAGANIVLNGFGDPA---PALAEIARHGVKAVHHPADL 60 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAA---VAFKSDDPM-PFDIKAEMTLKTNFFATRN 120 D+ I AL +E+GG+++LVNNA VA P+ +D + L F TR Sbjct: 61 SDVAQIEALFALAEREFGGVDILVNNAGIQHVAPVEQFPLESWDKIIALNLSAVFHGTRL 120 Query: 121 MCNELLPIMKPH--GRVVNISSLQCL 144 LP M+ GR++NI+S+ L Sbjct: 121 A----LPGMRARNWGRIINIASVHGL 142 >3RSH-A nrPDB Length = 251 Score = 62.0 bits (149), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 64/236 (27%), Positives = 102/236 (43%), Gaps = 57/236 (24%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 +VALVTGA+RGIG AIA EL + V+ TA + QA L G + L++ Sbjct: 12 GKVALVTGASRGIGKAIA-ELLAERGAKVIGTATSESGAQAISDYLGDNG---KGMALNV 67 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEM---TLKTNFFATRNM 121 + +SI A+ + E+GG+++LVNNA + + D + +K E ++TN + + Sbjct: 68 TNPESIEAVLKAITDEFGGVDILVNNAGI---TRDNLLMRMKEEEWSDIMETNLTSIFRL 124 Query: 122 CNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 +L M K GR++N+ G +V M Sbjct: 125 SKAVLRGMMKKRQGRIINV---------------------------GSVVGTMGN----- 152 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 G N Y +K GV ++ +AR + + + VN PG ++TDM Sbjct: 153 -------AGQAN--YAAAKAGVIGFTKSMAREVASR----GVTVNTVAPGFIETDM 195 >1Q7C-A nrPDB Length = 244 Score = 60.5 bits (145), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 65/240 (27%), Positives = 104/240 (43%), Gaps = 57/240 (23%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M+ ++ALVTGA+RGIG AIA L + V+ TA QA L A G + Sbjct: 1 MNFEGKIALVTGASRGIGRAIAETLAAR-GAKVIGTATSENGAQAISDYLGANG---KGL 56 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEM---TLKTNFFA 117 L++ D SI ++ + +R E+G +++LVNNA + + D + +K E ++TN + Sbjct: 57 MLNVTDPASIESVLEKIRAEFGEVDILVNNAGI---TRDNLLMRMKDEEWNDIIETNLSS 113 Query: 118 TRNMCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKF 175 + ++ M K HGR++ I S+ T+ G Sbjct: 114 VFRLSKAVMRAMMKKRHGRIITIGSVVG------------------TMGNG--------- 146 Query: 176 VEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 G N + +K G+ S+ LAR + + I VN PG ++TDM Sbjct: 147 ------------GQAN--FAAAKAGLIGFSKSLAREVASR----GITVNVVAPGFIETDM 188 >1X1T-A nrPDB Length = 260 Score = 59.7 bits (143), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 51/154 (33%), Positives = 74/154 (48%), Gaps = 11/154 (7%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTA-RDVARGQAAVQQLQAE-GLSPRFHQL 62 +VA+VTG+ GIGL IA L Q D+VL D A + L A+ G+ + Sbjct: 4 GKVAVVTGSTSGIGLGIATALAAQ-GADIVLNGFGDAAEIEKVRAGLAAQHGVKVLYDGA 62 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAV---AFKSDDPMPFDIKAEMTLKTNFFATR 119 D+ +++R L D ++ G +++LVNNA + A D P K + L N A Sbjct: 63 DLSKGEAVRGLVDNAVRQMGRIDILVNNAGIQHTALIEDFPTE---KWDAILALNLSAVF 119 Query: 120 NMCNELLPIMKPH--GRVVNISSLQCLRAFENCS 151 + LP MK GR++NI+S L A N S Sbjct: 120 HGTAAALPHMKKQGFGRIINIASAHGLVASANKS 153 >2C07-A nrPDB Length = 285 Score = 59.7 bits (143), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 64/243 (26%), Positives = 106/243 (43%), Gaps = 58/243 (23%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 ++VALVTGA RGIG IA+ L + S V+ +R + V ++++ G + D+ Sbjct: 44 NKVALVTGAGRGIGREIAKMLAKSVS-HVICISRTQKSCDSVVDEIKSFGYESSGYAGDV 102 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKA---EMTLKTN----FFA 117 + I + + + E+ +++LVNNA + + D + +K E L+TN F+ Sbjct: 103 SKKEEISEVINKILTEHKNVDILVNNAGI---TRDNLFLRMKNDEWEDVLRTNLNSLFYI 159 Query: 118 TRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 T+ + + I +GR++NISS+ L G++ Sbjct: 160 TQPISKRM--INNRYGRIINISSIVGL--------------------TGNV--------- 188 Query: 178 DTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDG 237 G N Y SK GV ++ LA+ L + I VNA PG + +DM Sbjct: 189 ----------GQAN--YSSSKAGVIGFTKSLAKELASR----NITVNAIAPGFISSDMTD 232 Query: 238 KDS 240 K S Sbjct: 233 KIS 235 >3OSU-A nrPDB Length = 246 Score = 59.7 bits (143), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 59/236 (25%), Positives = 103/236 (43%), Gaps = 53/236 (22%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 ++ ALVTGA+RGIG +IA +L + V A + +A V++++A+G+ Q ++ Sbjct: 4 TKSALVTGASRGIGRSIALQLAEEGYNVAVNYAGSKEKAEAVVEEIKAKGVDSFAIQANV 63 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEM---TLKTNFFATRNM 121 D ++A+ + ++G L+VLVNNA + + D + +K + + TN N Sbjct: 64 ADADEVKAMIKEVVSQFGSLDVLVNNAGI---TRDNLLMRMKEQEWDDVIDTNLKGVFNC 120 Query: 122 CNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 + P M + G ++N+SS+ + A N + Sbjct: 121 IQKATPQMLRQRSGAIINLSSV--VGAVGNPGQ--------------------------- 151 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 + Y +K GV L++ AR L + I VNA PG + +DM Sbjct: 152 ------------ANYVATKAGVIGLTKSAARELASR----GITVNAVAPGFIVSDM 191 >4DBZ-A nrPDB Length = 281 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 65/236 (27%), Positives = 95/236 (40%), Gaps = 52/236 (22%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 S VALVTGA GIGL IAR L ++ V + AR + +++L+ G+ D+ Sbjct: 26 SEVALVTGATSGIGLEIARRLGKEGL-RVFVCARGEEGLRTTLKELREAGVEADGRTCDV 84 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNA-----AVAFKSDDPMPFDIKAEMTLKTNFFATR 119 + I AL + + YG ++VLVNNA + D + D+ E L F T+ Sbjct: 85 RSVPEIEALVAAVVERYGPVDVLVNNAGRPGGGATAELADELWLDV-VETNLTGVFRVTK 143 Query: 120 NMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 + + + GR+VNI+S + Q H+ Sbjct: 144 QVLKAGGMLERGTGRIVNIAS----------TGGKQGLVHA------------------- 174 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 +PY SK GV ++ L L I VNA CPG V+T M Sbjct: 175 ------------APYSASKHGVVGFTKALGLELART----GITVNAVCPGFVETPM 214 >5U9P-A nrPDB Length = 265 Score = 58.5 bits (140), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 46/177 (25%), Positives = 81/177 (45%), Gaps = 7/177 (3%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 R AL+TG+ RGIGL +AR L + +V+ R+ + ++ + EG + D+ Sbjct: 20 GRRALITGSGRGIGLTLARGLA-EAGAAIVINDRNEEKAATLARRFRDEGFAADHAVFDV 78 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKS--DDPMPFDIKAEMTLKTNFFATRNMC 122 + +RA D G +++LVNNA + ++ D P D A M + N N+ Sbjct: 79 AEHAQVRAAIDEFEARVGAIDILVNNAGIQRRAPLDAFEPDDWHALM--RVNLDGVFNVA 136 Query: 123 NELLP--IMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 + I + HG+++NI S+Q A + + LT+G D + ++ Sbjct: 137 QAVARHMIARGHGKIINICSVQSELARPTIAPYAATKGAVRMLTKGMCADWARYGIQ 193 >3RKU-A nrPDB Length = 287 Score = 58.5 bits (140), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 53/187 (28%), Positives = 87/187 (46%), Gaps = 12/187 (6%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGD--VVLTARDVARGQAAVQQLQAEGLSPRFH- 60 + L+TGA+ GIG A A E +GD ++L AR + + + + + E + + H Sbjct: 32 AKKTVLITGASAGIGKATALEYLEASNGDMKLILAARRLEKLEELKKTIDQEFPNAKVHV 91 Query: 61 -QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIK-AEMTLKTNFFAT 118 QLDI + I+ + L +E+ +++LVNNA A SD + + TN A Sbjct: 92 AQLDITQAEKIKPFIENLPQEFKDIDILVNNAGKALGSDRVGQIATEDIQDVFDTNVTAL 151 Query: 119 RNMCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFV 176 N+ +LPI K G +VN+ S+ A+ S +F G D ++K + Sbjct: 152 INITQAVLPIFQAKNSGDIVNLGSIAGRDAYPTGSIYCASKF-----AVGAFTDSLRKEL 206 Query: 177 EDTKNEV 183 +TK V Sbjct: 207 INTKIRV 213 >2UVD-A nrPDB Length = 246 Score = 57.4 bits (137), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 62/238 (26%), Positives = 99/238 (41%), Gaps = 57/238 (23%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 +VALVTGA+RGIG AIA +L +Q + VV A + + V +++ G + D+ Sbjct: 4 GKVALVTGASRGIGRAIAIDLAKQGANVVVNYAGNEQKANEVVDEIKKLGSDAIAVRADV 63 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAE-------MTLKTNFFA 117 + + + + +G +++LVNNA V + D + +K E LK F Sbjct: 64 ANAEDVTNMVKQTVDVFGQVDILVNNAGV---TKDNLLMRMKEEEWDTVINTNLKGVFLC 120 Query: 118 TRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 T+ + ++ + HGR+VNI+S+ Sbjct: 121 TKAVSRFMMR--QRHGRIVNIASVVG---------------------------------- 144 Query: 178 DTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 V G N Y +K GV L++ A+ L + I VNA PG + TDM Sbjct: 145 -----VTGNPGQAN--YVAAKAGVIGLTKTSAKELASR----NITVNAIAPGFIATDM 191 >3LYL-A nrPDB Length = 247 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 62/239 (25%), Positives = 99/239 (41%), Gaps = 46/239 (19%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 MS +VALVTGA+RGIG +A L + VV TA A + ++ +G R Sbjct: 1 MSLNEKVALVTGASRGIGFEVAHALASK-GATVVGTATSQASAEKFENSMKEKGFKARGL 59 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 L+I D++SI+ ++ E +++LVNNA + D+ M R Sbjct: 60 VLNISDIESIQNFFAEIKAENLAIDILVNNAGIT--RDNLM----------------MRM 101 Query: 121 MCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 +E ++ N+SS+ R + C + ++ ++ G +V Sbjct: 102 SEDEWQSVINT-----NLSSI--FRMSKECVRGMMKKRWGRIISIGSVVG---------- 144 Query: 181 NEVHEREGWPN-SPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 G P + Y +K GV S+ LA + + I VN PG + TDM K Sbjct: 145 -----SAGNPGQTNYCAAKAGVIGFSKSLAYEVASR----NITVNVVAPGFIATDMTDK 194 >6NRP-A nrPDB Length = 263 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 42/146 (28%), Positives = 78/146 (53%), Gaps = 5/146 (3%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARD-VARGQAAVQQLQAEGLSPRFHQ 61 S +R LVTG++RGIG AIA +L + DV + AR A + VQ++QA G + + Sbjct: 22 SMTRRILVTGSSRGIGKAIALQLAKA-GFDVTVHARSRQAEAEQVVQEIQALGQNSHYLM 80 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 D+++ Q+++ + + +++GG +V NA + P D + + T+ N+ Sbjct: 81 FDVNERQTVQQILEQDVEQHGGFYGVVLNAGLTHDGAFPALTDQDWDEVISTSLDGFYNV 140 Query: 122 CNEL-LPI--MKPHGRVVNISSLQCL 144 L +P+ ++ GR+V +SS+ + Sbjct: 141 LKPLIMPMIHLRKGGRIVTLSSVSGI 166 >3V2G-A nrPDB Length = 271 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 67/249 (26%), Positives = 104/249 (41%), Gaps = 62/249 (24%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVA-RGQAAVQQLQAEGLSPRF 59 +S + A VTG +RGIG AIA+ L + + V LT + A R QA V +++ G Sbjct: 27 ISLAGKTAFVTGGSRGIGAAIAKRLALEGAA-VALTYVNAAERAQAVVSEIEQAGGRAVA 85 Query: 60 HQLDIDDLQSI-RALRDFLRKEYGGLNVLVNNAAVAFKSDDPMP------FDIKAEMTLK 112 + D D ++I +A+R+ + + GGL++LVN+A + + P+ FD + + Sbjct: 86 IRADNRDAEAIEQAIRETV-EALGGLDILVNSAGIWHSA--PLEETTVADFDEVMAVNFR 142 Query: 113 TNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLM 172 F A R+ L GR++ I S +L +L+ Sbjct: 143 APFVAIRSASRHL----GDGGRIITIGS--------------------------NLAELV 172 Query: 173 KKFVEDTKNEVHEREGWPN-SPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPV 231 WP S Y SK + L++ LAR L + I VN PG Sbjct: 173 P---------------WPGISLYSASKAALAGLTKGLARDLGPR----GITVNIVHPGST 213 Query: 232 KTDMDGKDS 240 TDM+ D Sbjct: 214 DTDMNPADG 222 >2PNF-A nrPDB Length = 248 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 62/236 (26%), Positives = 104/236 (44%), Gaps = 55/236 (23%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 +V+LVTG+ RGIG AIA +L S V++T R +A +++ A + H ++++ Sbjct: 8 KVSLVTGSTRGIGRAIAEKLASAGS-TVIITGTSGERAKAVAEEI-ANKYGVKAHGVEMN 65 Query: 66 DL--QSIRALRDFLRKEYGGLNVLVNNAAVA----FKSDDPMPFDIKAEMTLKTNFFATR 119 L +SI + + G+++LVNNA + F + ++ ++ L F T+ Sbjct: 66 LLSEESINKAFEEIYNLVDGIDILVNNAGITRDKLFLRMSLLDWEEVLKVNLTGTFLVTQ 125 Query: 120 NMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 N ++ I + GR+VNISS+ V T Sbjct: 126 NSLRKM--IKQRWGRIVNISSV----------------------------------VGFT 149 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 N G N Y +K G+ ++ LA+ L + +LVNA PG ++TDM Sbjct: 150 GN-----VGQVN--YSTTKAGLIGFTKSLAKELAPR----NVLVNAVAPGFIETDM 194 >1YXM-A nrPDB Length = 303 Score = 55.5 bits (132), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 46/141 (32%), Positives = 66/141 (46%), Gaps = 10/141 (7%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH----- 60 +VA+VTG GIG AI +EL + +VV+ +R + R ++A +LQA L P Sbjct: 19 QVAIVTGGATGIGKAIVKELL-ELGSNVVIASRKLERLKSAADELQAN-LPPTKQARVIP 76 Query: 61 -QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATR 119 Q +I + + + L +G +N LVNN F S L+TN T Sbjct: 77 IQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTF 136 Query: 120 NMCNELL-PIMKPH-GRVVNI 138 MC + MK H G +VNI Sbjct: 137 YMCKAVYSSWMKEHGGSIVNI 157 >3O4R-A nrPDB Length = 261 Score = 54.3 bits (129), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 69/243 (28%), Positives = 95/243 (39%), Gaps = 63/243 (25%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 ++VALVT + GIG AIAR L Q VV+++R AV LQ EGLS Sbjct: 14 ANKVALVTASTDGIGFAIARRLA-QDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCH 72 Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPF-----DIKAEM---TLKTNF 115 + + L K +GG+++LV+NAAV PF D+ E+ TL N Sbjct: 73 VGKAEDRERLVATAVKLHGGIDILVSNAAVN-------PFFGSIMDVTEEVWDKTLDINV 125 Query: 116 FATRNMCNELLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMK 173 A M ++P M+ G VV +SS+ Sbjct: 126 KAPALMTKAVVPEMEKRGGGSVVIVSSIAAF----------------------------- 156 Query: 174 KFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKT 233 G+ SPY VSK + L++ LA L + I VN PG +KT Sbjct: 157 ----------SPSPGF--SPYNVSKTALLGLTKTLAIELAPR----NIRVNCLAPGLIKT 200 Query: 234 DMD 236 Sbjct: 201 SFS 203 >5CDY-A nrPDB Length = 244 Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 63/240 (26%), Positives = 99/240 (41%), Gaps = 57/240 (23%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 MS ++ALVTGA+RGIG AIA L + G V+ +G A+ E + + Sbjct: 1 MSFEGKIALVTGASRGIGRAIAELLVER--GACVIGTATSEKGAEAISAYLGE--NGKGL 56 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEM---TLKTNFFA 117 L++ D SI + +R E+G +++LVNNA + + D + +K + + TN + Sbjct: 57 MLNVVDPTSIDTVLATIRAEFGEVDILVNNAGI---TRDNLLMRMKDDEWQDIIDTNLTS 113 Query: 118 TRNMCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKF 175 + ++ M K GR++ I G +V M Sbjct: 114 VFRLSKAVMRAMMKKRFGRIITI---------------------------GSVVGTMGN- 145 Query: 176 VEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 G N Y +K GV S+ LAR + + I VN PG ++TDM Sbjct: 146 -----------AGQVN--YAAAKAGVIGFSKSLAREVASR----GITVNVVAPGFIETDM 188 >2ZAT-A nrPDB Length = 260 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 64/235 (27%), Positives = 92/235 (39%), Gaps = 49/235 (20%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 ++VALVT + GIGLAIAR L Q VV+++R V LQ EGLS + Sbjct: 14 NKVALVTASTDGIGLAIARRLA-QDGAHVVVSSRKQENVDRTVATLQGEGLSVTGTVCHV 72 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAV-AFKSDDPMPFDIKAEMTLKTNFFATRNMCN 123 + L +GG+++LV+NAAV F + + + L N AT M Sbjct: 73 GKAEDRERLVAMAVNLHGGVDILVSNAAVNPFFGNIIDATEEVWDKILHVNVKATVLMTK 132 Query: 124 ELLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKN 181 ++P M+ G V+ +SS+ F N Sbjct: 133 AVVPEMEKRGGGSVLIVSSVGAYHPFPNL------------------------------- 161 Query: 182 EVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMD 236 PY VSK + L++ LA L + I VN PG +KT+ Sbjct: 162 ----------GPYNVSKTALLGLTKNLAVELAPR----NIRVNCLAPGLIKTNFS 202 >5OJG-A nrPDB Length = 260 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 65/246 (26%), Positives = 98/246 (39%), Gaps = 62/246 (25%) Query: 2 SSCSR----VALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSP 57 S+C R VA+VT A +GIGLAIA L + VV+ +R+ A++ L+ +GL+ Sbjct: 3 SNCRRFEGKVAIVTAATKGIGLAIAERLLDE-GASVVIGSRNQKNVDEAIEYLKNKGLTK 61 Query: 58 ----RFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKT 113 H DD + L DF +++G +N+LVNN + +P Sbjct: 62 VAGIAGHIASTDDQ---KKLVDFTLQKFGKINILVNNHGI-----NP------------- 100 Query: 114 NFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFE-NCSEDLQ--ERFHSETLTEGDLVD 170 G ++ +S + FE N Q + H EG Sbjct: 101 -----------------AFGHILEVSDQVWDKLFEVNVKAGFQMTKLVHPHIAKEGGGAI 143 Query: 171 LMKKFVEDTKNEVHEREGWPN-SPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPG 229 + K+ P + YGV+K + L+R LA L + D I VN PG Sbjct: 144 IFNASYSAYKSP-------PGIAAYGVTKTTLVGLTRALAMGLAK----DNIRVNGIAPG 192 Query: 230 PVKTDM 235 +KT M Sbjct: 193 VIKTKM 198 >1GEG-A nrPDB Length = 256 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 65/248 (26%), Positives = 103/248 (41%), Gaps = 46/248 (18%) Query: 6 RVALVTGANRGIGLAIARELCRQ-FSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 +VALVTGA +GIG AIA L + F+ V + + A +A ++ G ++D+ Sbjct: 3 KVALVTGAGQGIGKAIALRLVKDGFA--VAIADYNDATAKAVASEINQAGGHAVAVKVDV 60 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE 124 D + A + RK GG +V+VNNA VA + P + ++ E Sbjct: 61 SDRDQVFAAVEQARKTLGGFDVIVNNAGVAPST----PIE---------------SITPE 101 Query: 125 LLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVH 184 ++ +V NI+ + + E ++ H G +++ + E+ Sbjct: 102 IVD------KVYNINVKGVIWGIQAAVEAFKKEGHG-----GKIINACSQAGHVGNPEL- 149 Query: 185 EREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTV 244 + Y SK V L++ AR L I VN CPG VKT M + R V Sbjct: 150 -------AVYSSSKFAVRGLTQTAARDLAPL----GITVNGYCPGIVKTPMWAEID-RQV 197 Query: 245 EEGAETPV 252 E A P+ Sbjct: 198 SEAAGKPL 205 >4IIV-A nrPDB Length = 267 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 39/143 (27%), Positives = 72/143 (50%), Gaps = 3/143 (2%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 ++ SR LVTGA++GIG AIAR+L V RD A Q + + A G + R Sbjct: 23 NAMSRSVLVTGASKGIGRAIARQLAADGFNIGVHYHRDAAGAQETLNAIVANGGNGRLLS 82 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 D+ + + R + + ++G +V+NA +A + P + + + TN + N+ Sbjct: 83 FDVANREQCREVLEHEIAQHGAWYGVVSNAGIARDAAFPALSNDDWDAVIHTNLDSFYNV 142 Query: 122 CNE-LLPIM--KPHGRVVNISSL 141 ++P++ + GR++ +SS+ Sbjct: 143 IQPCIMPMIGARQGGRIITLSSV 165 >3EMK-A nrPDB Length = 246 Score = 51.6 bits (122), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 45/142 (31%), Positives = 73/142 (51%), Gaps = 10/142 (7%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL- 62 R ALVTGA G+G AIAR L Q + + R + +++L AE L R Sbjct: 6 TGRKALVTGATGGLGEAIARALHAQGAIVGLHGTR-----EEKLKELAAE-LGERIFVFP 59 Query: 63 -DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 ++ D ++++AL +E GG+++LVNNA + D + L N + N+ Sbjct: 60 ANLSDREAVKALGQKAEEEMGGVDILVNNAGITRDGLFVRMSDEDWDAVLTVNLTSVFNL 119 Query: 122 CNELL-PIM-KPHGRVVNISSL 141 EL P+M + +GR++NI+S+ Sbjct: 120 TRELTHPMMRRRNGRIINITSI 141 >3OEC-A nrPDB Length = 317 Score = 51.6 bits (122), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 75/292 (25%), Positives = 112/292 (38%), Gaps = 83/292 (28%) Query: 5 SRVALVTGANRGIG------LA------IARELCRQFSGDVVLTARDVARG-----QAAV 47 +VA +TGA RG G LA +A +LCRQ D A+G + V Sbjct: 46 GKVAFITGAARGQGRTHAVRLAQDGADIVAIDLCRQQPN------LDYAQGSPEELKETV 99 Query: 48 QQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKA 107 + ++ +G Q D+ DL S++A+ D E+G +++LV+N ++ + + D + Sbjct: 100 RLVEEQGRRIIARQADVRDLASLQAVVDEALAEFGHIDILVSNVGISNQGEVVSLTDQQW 159 Query: 108 EMTLKTNFFATRNMCNELLPIMKPHGR---VVNISSLQCLRAFENCSEDLQERFHSETLT 164 L+TN + C +LP M G+ V+ +SS LR Sbjct: 160 SDILQTNLIGAWHACRAVLPSMIERGQGGSVIFVSSTVGLR------------------- 200 Query: 165 EGDLVDLMKKFVEDTKNEVHEREGWPN-SPYGVSKLGVTVLSRILARRLDEKRKADRILV 223 G P S Y SK GV L LA + I V Sbjct: 201 -----------------------GAPGQSHYAASKHGVQGLMLSLANEVGRH----NIRV 233 Query: 224 NACCPGPVKTDMDGKDSIR----------TVEEGAETPVYLALLPPDATEPQ 265 N+ PG V T+M + + T E+ AE L LLP EP+ Sbjct: 234 NSVNPGAVNTEMALNEKLLKMFLPHLENPTREDAAELFSQLTLLPIPWVEPE 285 >3V2H-A nrPDB Length = 281 Score = 51.6 bits (122), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 48/159 (30%), Positives = 72/159 (45%), Gaps = 25/159 (15%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQL-----QAEGLS 56 S ++ A++TG+ GIGLAIAR L + A V G A ++ + GLS Sbjct: 22 SMMTKTAVITGSTSGIGLAIARTLAKA-------GANIVLNGFGAPDEIRTVTDEVAGLS 74 Query: 57 PR---FHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFK---SDDPMP-FDIKAEM 109 H D+ I + + +GG ++LVNNA V F D P+ +D + Sbjct: 75 SGTVLHHPADMTKPSEIADMMAMVADRFGGADILVNNAGVQFVEKIEDFPVEQWDRIIAV 134 Query: 110 TLKTNFFATRNMCNELLPIMKPH--GRVVNISSLQCLRA 146 L ++F R +P MK GR++NI+S L A Sbjct: 135 NLSSSFHTIRGA----IPPMKKKGWGRIINIASAHGLVA 169 >3WOH-A nrPDB Length = 251 Score = 51.6 bits (122), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 55/238 (23%), Positives = 95/238 (39%), Gaps = 57/238 (23%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 +VALVTG +RG+G A+A L R + ++ D + + +++ G + R ++ D+ Sbjct: 11 GKVALVTGGSRGLGRAMALRLARDGAAVAIVYVSDDSSAKETQGEIERLGGTARSYRCDV 70 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNA-------AVAFKSDDPMPFDIKAEMTLKTNFFA 117 D + + + + G +++LVNNA A + K +D +D LK F Sbjct: 71 SDAEQVTRCVKAVTADLGPVDILVNNAGIIRDGLAASIKDED---YDAVMNTNLKGAFLF 127 Query: 118 TRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 + I K G ++NISS+ Sbjct: 128 IKACYFGF--IRKRSGSIINISSV------------------------------------ 149 Query: 178 DTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 + V G N Y +K G+ L++ +A+ L E+ + NA PG + TDM Sbjct: 150 ---SGVFGSAGQAN--YASAKAGLIGLTKSIAKELAER----NVRCNAVAPGLIATDM 198 >2CFC-A nrPDB Length = 250 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 56/193 (29%), Positives = 85/193 (44%), Gaps = 41/193 (21%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARG-QAAVQQLQAEGL--SPRFH- 60 SRVA+VTGA+ G GLAIA R +ARG + A L AE L + R H Sbjct: 2 SRVAIVTGASSGNGLAIAT--------------RFLARGDRVAALDLSAETLEETARTHW 47 Query: 61 ----------QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMT 110 + D+ D + A +++G ++VLVNNA + S+ + E Sbjct: 48 HAYADKVLRVRADVADEGDVNAAIAATMEQFGAIDVLVNNAGITGNSEAGVLHTTPVEQF 107 Query: 111 LKTNFFATRNM---CNELLP--IMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTE 165 K R + C +LP +++ G +VNI+S+ L AF S + T ++ Sbjct: 108 DKVMAVNVRGIFLGCRAVLPHMLLQGAGVIVNIASVASLVAFPGRS--------AYTTSK 159 Query: 166 GDLVDLMKKFVED 178 G ++ L K D Sbjct: 160 GAVLQLTKSVAVD 172 >3VZS-A nrPDB Length = 257 Score = 51.2 bits (121), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 40/144 (27%), Positives = 68/144 (47%), Gaps = 6/144 (4%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 S R+A VTG GIG AI + L + V + R + ++Q +A G + Sbjct: 11 GSTQRIAYVTGGMGGIGTAICQRLAKDGFRVVAGCGPNSPRREKWLEQQKALGFDFIASE 70 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAA----VAFKSDDPMPFDIKAEMTLKTNFFA 117 ++ D S + D ++ E G ++VL+NNA V F+ +D + L + F Sbjct: 71 GNVADWDSTKTAFDKVKSEVGEVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNV 130 Query: 118 TRNMCNELLPIMKPHGRVVNISSL 141 T+ + + + + GR+VNISS+ Sbjct: 131 TKQVIDGMAD--RGWGRIVNISSV 152 >4DMM-A nrPDB Length = 269 Score = 51.2 bits (121), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 62/237 (26%), Positives = 92/237 (38%), Gaps = 57/237 (24%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 R+ALVTGA+RGIG AIA EL + V A V + A G + D+ Sbjct: 29 RIALVTGASRGIGRAIALELAAAGAKVAVNYASSAGAADEVVAAIAAAGGEAFAVKADVS 88 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAVA-------FKSDDPMPFDIKAEMTLKTNFFAT 118 + AL + + +G L+VLVNNA + K DD + ++ L F + Sbjct: 89 QESEVEALFAAVIERWGRLDVLVNNAGITRDTLLLRMKRDD---WQSVLDLNLGGVFLCS 145 Query: 119 RNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 R +L + GR++NI+S+ Sbjct: 146 RAAAKIMLK--QRSGRIINIASV------------------------------------- 166 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 V E + Y +K GV L++ +A+ L + I VNA PG + TDM Sbjct: 167 ----VGEMGNPGQANYSAAKAGVIGLTKTVAKELASR----GITVNAVAPGFIATDM 215 >5ITV-A nrPDB Length = 255 Score = 50.8 bits (120), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 59/250 (23%), Positives = 101/250 (40%), Gaps = 56/250 (22%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M+ + L+TG GIG A + Q +VV+ D A+G+A V++ + L F Sbjct: 3 MNLTDKTVLITGGASGIGYAAVQAFLGQ-QANVVVADIDEAQGEAMVRKENNDRL--HFV 59 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSD----DPMPFDIKAEMTLKTNFF 116 Q DI D + + + +GGL+VL+NNA + + + ++ ++ L F Sbjct: 60 QTDITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELSDWNKVLQVNLTGMFL 119 Query: 117 ATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFV 176 +++ +L K G ++N S+ L A Sbjct: 120 MSKHALKHMLAAGK--GNIINTCSVGGLVA------------------------------ 147 Query: 177 EDTKNEVHEREGWPNSP-YGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 WP+ P Y SK GV L++ +A +D + +I VN CPG + T + Sbjct: 148 ------------WPDIPAYNASKGGVLQLTKSMA--VDYAKH--QIRVNCVCPGIIDTPL 191 Query: 236 DGKDSIRTVE 245 + K + E Sbjct: 192 NEKSFLENNE 201 >3KZV-A nrPDB Length = 254 Score = 50.8 bits (120), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 48/148 (32%), Positives = 73/148 (49%), Gaps = 8/148 (5%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL--D 63 +V LVTG +RGIG +I L FS D VAR +A +++L+ E RF + D Sbjct: 3 KVILVTGVSRGIGKSIVDVL---FSLDKDTVVYGVARSEAPLKKLK-EKYGDRFFYVVGD 58 Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLK-TNFFATRNMC 122 I + ++ L + K +G ++ LV NA V + D+ A L NFF+ ++ Sbjct: 59 ITEDSVLKQLVNAAVKGHGKIDSLVANAGVLEPVQNVNEIDVNAWKKLYDINFFSIVSLV 118 Query: 123 NELLP-IMKPHGRVVNISSLQCLRAFEN 149 LP + K +G VV +SS C F + Sbjct: 119 GIALPELKKTNGNVVFVSSDACNMYFSS 146 >2HSD-A nrPDB Length = 253 Score = 50.4 bits (119), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 67/251 (26%), Positives = 99/251 (39%), Gaps = 65/251 (25%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 + ++TG RG+G AR+ + VVL G A ++L G + R+ LD Sbjct: 4 SGKTVIITGGARGLGAEAARQAVAAGA-RVVLADVLDEEGAATAREL---GDAARYQHLD 59 Query: 64 I---DDLQSIRALRDFLRKEYGGLNVLVNNAAVA----FKSDDPMPFDIKAEMTLKTNFF 116 + +D Q + A + R+E+G ++ LVNNA ++ +++ F E+ L F Sbjct: 60 VTIEEDWQRVVA---YAREEFGSVDGLVNNAGISTGMFLETESVERFRKVVEINLTGVFI 116 Query: 117 ATRNMCNELLPIMK--PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKK 174 + ++P MK G +VNISS L LT Sbjct: 117 GMKT----VIPAMKDAGGGSIVNISSAAGLMGL--------------ALT---------- 148 Query: 175 FVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD 234 S YG SK GV LS++ A L DRI VN+ PG T Sbjct: 149 -----------------SSYGASKWGVRGLSKLAAVELG----TDRIRVNSVHPGMTYTP 187 Query: 235 MDGKDSIRTVE 245 M + IR E Sbjct: 188 MTAETGIRQGE 198 >3WTC-A nrPDB Length = 262 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 64/239 (26%), Positives = 100/239 (41%), Gaps = 51/239 (21%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 MS ++A VTGA +GIG AIA L + DV+L DV + A + E L R Sbjct: 4 MSLSGKIAAVTGAAQGIGKAIALRLAKD-GADVILL--DVKQDTLAETAKEVEALGRRAV 60 Query: 61 QL--DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIK-AEMTLKTNFFA 117 L DI + R+ K GGL+++VNNA + P+ DI+ AE+ Sbjct: 61 ALTADISNRDQFRSTLADAAKTLGGLDIMVNNAGIC--QVKPI-LDIEPAEIE------- 110 Query: 118 TRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 ++ +I+ L + + +E+ T+G +++ Sbjct: 111 ----------------KIFSINVQGVLWGMQAAATLFKEKG-----TKGKIINAC----- 144 Query: 178 DTKNEVHEREGWP-NSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 + EG+P Y +K V L++ A+ L + I VN+ CPG V TDM Sbjct: 145 ----SIAGHEGYPLLGAYSATKFAVRALTQSAAKEL----ASSGITVNSYCPGIVGTDM 195 >3WYE-A nrPDB Length = 256 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 61/243 (25%), Positives = 94/243 (38%), Gaps = 69/243 (28%) Query: 6 RVALVTGANRGIGLAIARELCRQ-FSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 +VALVTGA +GIG AIA L + F+ V + + A +A ++ G ++D+ Sbjct: 3 KVALVTGAGQGIGKAIALRLVKDGFA--VAIADYNDATAKAVASEINQAGGHAVAVKVDV 60 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE 124 D + A + RK GG +V+VNNA +A + Sbjct: 61 SDRDQVFAAVEQARKTLGGFDVIVNNAGIA-----------------------------Q 91 Query: 125 LLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVH 184 + P++ E EDL++ + + + ++ VE K E H Sbjct: 92 IKPLL------------------EVTEEDLKQIYSVNVFS---VFFGIQAAVEAFKKEGH 130 Query: 185 -----------EREGWPN-SPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVK 232 +G+P S Y +K V L++ AR L I VN CPG V Sbjct: 131 GGKIINAASIAAIQGFPILSAYSTTKFAVRGLTQTAARDLAPL----GITVNGYCPGIVG 186 Query: 233 TDM 235 T M Sbjct: 187 TGM 189 >3OIC-A nrPDB Length = 258 Score = 49.7 bits (117), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 55/232 (23%), Positives = 90/232 (38%), Gaps = 47/232 (20%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 ++ ALVTG++RG+G A A L V+ AR ++++ G+ + ++ Sbjct: 4 NKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALETAEEIEKLGVKVLVVKANV 63 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE 124 I+ + + + +G L+V VNNAA + + T+ N A E Sbjct: 64 GQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELEETHWDWTMNINAKALLFCAQE 123 Query: 125 LLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNE 182 +M+ + G +V+ISSL +R EN Sbjct: 124 AAKLMEKNGGGHIVSISSLGSIRYLENY-------------------------------- 151 Query: 183 VHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD 234 + GVSK + L+R LA L K +I+VNA G + TD Sbjct: 152 ---------TTVGVSKAALEALTRYLAVELSPK----QIIVNAVSGGAIDTD 190 >2NWQ-A nrPDB Length = 272 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 47/149 (31%), Positives = 70/149 (46%), Gaps = 16/149 (10%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEG-LSPRFH 60 S S +TGA G G A AR + +VLT R R QA +L A+ + P Sbjct: 18 SHMSSTLFITGATSGFGEACARRFA-EAGWSLVLTGRREERLQALAGELSAKTRVLPL-- 74 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSD-----DPMPFDIKAEMTLKTNF 115 LD+ D ++ A D L +E+ L L+NNA +A +D D +D + +K Sbjct: 75 TLDVRDRAAMSAAVDNLPEEFATLRGLINNAGLALGTDPAQSCDLDDWDTMVDTNIKGLL 134 Query: 116 FATRNMCNELLPIMKPHG---RVVNISSL 141 ++TR LLP + HG +VN+ S+ Sbjct: 135 YSTR----LLLPRLIAHGAGASIVNLGSV 159 >2CDH-G nrPDB Length = 244 Score = 48.5 bits (114), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 57/241 (23%), Positives = 92/241 (38%), Gaps = 57/241 (23%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 S V +VTGA+RGIG AIA L + +V AR + +Q++A G D+ Sbjct: 1 SPVVVVTGASRGIGKAIALSLGKAGCKVLVNYARSAKAAEEVSKQIEAYGGQAITFGGDV 60 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKA-------EMTLKTNFFA 117 + A+ +G ++V+VNNA + + D + +K ++ L F Sbjct: 61 SKEADVEAMMKTAIDAWGTIDVVVNNAGI---TRDTLLIRMKKSQWDEVIDLNLTGVFLC 117 Query: 118 TRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 T+ ++ K GR++NI+S+ L N + Sbjct: 118 TQAATKIMMK--KRKGRIINIASVVGL--IGNIGQ------------------------- 148 Query: 178 DTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDG 237 + Y +K GV S+ AR + I VN CPG + +DM Sbjct: 149 --------------ANYAAAKAGVIGFSKTAAREGASR----NINVNVVCPGFIASDMTA 190 Query: 238 K 238 K Sbjct: 191 K 191 >3GRP-A nrPDB Length = 266 Score = 48.1 bits (113), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 44/143 (30%), Positives = 69/143 (48%), Gaps = 14/143 (9%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVL---TARDVARGQAAVQQLQAE-GLSPRFH 60 R ALVTGA GIG AIAR C G +V T D ++++ A+ G Sbjct: 27 GRKALVTGATGGIGEAIAR--CFHAQGAIVGLHGTRED------KLKEIAADLGKDVFVF 78 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 ++ D +SI+ L + +E G+++LVNNA + D + L N A Sbjct: 79 SANLSDRKSIKQLAEVAEREMEGIDILVNNAGITRDGLFVRMQDQDWDDVLAVNLTAAST 138 Query: 121 MCNELLPIM--KPHGRVVNISSL 141 + EL+ M + +GR++NI+S+ Sbjct: 139 LTRELIHSMMRRRYGRIINITSI 161 >2HQ1-A nrPDB Length = 247 Score = 47.4 bits (111), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 50/237 (21%), Positives = 96/237 (40%), Gaps = 57/237 (24%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARG-QAAVQQLQAEGLSPRFHQLDI 64 + A+VTG++RG+G AIA +L ++VL + A ++ +A G++ + D+ Sbjct: 6 KTAIVTGSSRGLGKAIAWKLG-NMGANIVLNGSPASTSLDATAEEFKAAGINVVVAKGDV 64 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPM------PFDIKAEMTLKTNFFAT 118 + + + + +G +++LVNNA + D M +D LK+ + T Sbjct: 65 KNPEDVENMVKTAMDAFGRIDILVNNAGIT--RDTLMLKMSEKDWDDVLNTNLKSAYLCT 122 Query: 119 RNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + + +L + G+++NI+S+ + N + Sbjct: 123 KAVSKIMLK--QKSGKIINITSIAGI--IGNAGQ-------------------------- 152 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 + Y SK G+ ++ +A+ K I NA PG +KTDM Sbjct: 153 -------------ANYAASKAGLIGFTKSIAKEFAAK----GIYCNAVAPGIIKTDM 192 >3RWB-A nrPDB Length = 247 Score = 47.4 bits (111), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 63/236 (26%), Positives = 97/236 (41%), Gaps = 56/236 (23%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 + ALVTGA +GIG AIA L G V+ + D+ + A + G R D Sbjct: 5 AGKTALVTGAAQGIGKAIAARLAAD--GATVIVS-DI-NAEGAKAAAASIGKKARAIAAD 60 Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVA-FKSDDPMPFDIK---AEMTLKTNFFATR 119 I D S++AL ++ GG+++LVNNA++ F + D + D ++ L F TR Sbjct: 61 ISDPGSVKALFAEIQALTGGIDILVNNASIVPFVAWDDVDLDHWRKIIDVNLTGTFIVTR 120 Query: 120 NMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 +++ K GRV++I+S F + T Sbjct: 121 AGTDQMRAAGKA-GRVISIAS---------------NTFFAGT----------------- 147 Query: 180 KNEVHEREGWPN-SPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD 234 PN + Y +K GV +R LA L + I NA PG +++D Sbjct: 148 ----------PNMAAYVAAKGGVIGFTRALATELGKY----NITANAVTPGLIESD 189 >4HP8-A nrPDB Length = 247 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 46/146 (31%), Positives = 69/146 (47%), Gaps = 15/146 (10%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 R ALVTGAN G+G AIA L +VV AR + + +G + +D Sbjct: 9 GRKALVTGANTGLGQAIAVGLAAA-GAEVVCAARRAP--DETLDIIAKDGGNASALLIDF 65 Query: 65 DD-LQSIRALRDFLRKEYGGLNVLVNNAAVAFKSD----DPMPFDIKAEMTLKTNFFATR 119 D L + + D G ++LVNNA + ++D + +D ++ LK FF T+ Sbjct: 66 ADPLAAKDSFTD------AGFDILVNNAGIIRRADSVEFSELDWDEVMDVNLKALFFTTQ 119 Query: 120 NMCNELLPIMKPHGRVVNISSLQCLR 145 ELL + G+VVNI+SL + Sbjct: 120 AFAKELLAKGRS-GKVVNIASLLSFQ 144 >4MOW-A nrPDB Length = 256 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 40/142 (28%), Positives = 62/142 (43%), Gaps = 8/142 (5%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 +VA+VTGA++GIG AIA+ L + + VV A A A V + G D Sbjct: 13 AGKVAIVTGASKGIGAAIAKALADEGAAVVVNYASSKAGADAVVSAITEAGGRAVAVGGD 72 Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLK----TNFFATR 119 + + + D + YG L+VLVNN+ V + P + E + TN F Sbjct: 73 VSKAADAQRIVDTAIETYGRLDVLVNNSGVY----EFAPIEAITEEHYRRQFDTNVFGVL 128 Query: 120 NMCNELLPIMKPHGRVVNISSL 141 + + ++NISS+ Sbjct: 129 LTTQAAVKHLGEGASIINISSV 150 >3V8B-A nrPDB Length = 283 Score = 45.8 bits (107), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 46/157 (29%), Positives = 73/157 (46%), Gaps = 18/157 (11%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M+ S VAL+TGA GIG A A L +T + R + V+++ E + Sbjct: 24 MNQPSPVALITGAGSGIGRATALALAADG-----VTVGALGRTRTEVEEVADEIVGAGGQ 78 Query: 61 QLDI-----DDLQSIRALRDFLRKEYGGLNVLVNNA---AVAFKSDDPMPFDIKAEMTLK 112 + + D+LQ A+RD + K +G L+++V NA V DD PF+ + T+ Sbjct: 79 AIALEADVSDELQMRNAVRDLVLK-FGHLDIVVANAGINGVWAPIDDLKPFEW--DETIA 135 Query: 113 TNFFATRNMCNELLPIMKPH--GRVVNISSLQCLRAF 147 N T + +P +K G +V +SS+ R F Sbjct: 136 VNLRGTFLTLHLTVPYLKQRGGGAIVVVSSINGTRTF 172 >4K6F-A nrPDB Length = 255 Score = 45.8 bits (107), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 35/141 (24%), Positives = 69/141 (48%), Gaps = 6/141 (4%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 R+A+VTG G+G A++ L VV + + + ++ A G + +D+ Sbjct: 12 RIAVVTGGMGGLGEAVSIRLNDAGHRVVVTYSPNNTGADRWLTEMHAAGREFHAYPVDVA 71 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAV----AFKSDDPMPFDIKAEMTLKTNFFATRNM 121 D S + + + ++ G +++LVNNA + + D + +D L + F T+ + Sbjct: 72 DHDSCQQCIEKIVRDVGPVDILVNNAGITRDMTLRKLDKVNWDAVIRTNLDSVFNMTKPV 131 Query: 122 CNELLPIMKPHGRVVNISSLQ 142 C+ + + + GR+VNISS+ Sbjct: 132 CDGM--VERGWGRIVNISSVN 150 >3F9I-A nrPDB Length = 249 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 38/141 (26%), Positives = 71/141 (50%), Gaps = 16/141 (11%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 + +L+TGA+ GIG AIAR L + V+++ + + ++ L+ + +++ Sbjct: 15 KTSLITGASSGIGSAIAR-LLHKLGSKVIISGSNEEKLKSLGNALKDN------YTIEVC 67 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAV-----AFKSDDPMPFDIKAEMTLKTNFFATRN 120 +L + + + K L++LV NA + A + D FD ++ LK NF R Sbjct: 68 NLANKEECSNLISKT-SNLDILVCNAGITSDTLAIRMKDQ-DFDKVIDINLKANFILNRE 125 Query: 121 MCNELLPIMKPHGRVVNISSL 141 ++ I K +GR++NISS+ Sbjct: 126 AIKKM--IQKRYGRIINISSI 144 >4CQM-B nrPDB Length = 244 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 58/235 (24%), Positives = 91/235 (38%), Gaps = 57/235 (24%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 +V V G +RGIG A+A+ + R+ + + AR++ +AA L + L+ D+ Sbjct: 10 KVCAVFGGSRGIGRAVAQLMARK-GYRLAVIARNLEGAKAAAGDLGGDHLA---FSCDVA 65 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAE---MTLKTNFFATRNMC 122 ++ + L K G +N LVN A + + D + K E L TN + C Sbjct: 66 KEHDVQNTFEELEKHLGRVNFLVNAAGI---NRDGLLVRTKTEDMVSQLHTNLLGSMLTC 122 Query: 123 NELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 + M + G +VN+ S+ L+ N + Sbjct: 123 KAAMRTMIQQQGGSIVNVGSIVGLKG--NSGQ---------------------------- 152 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 S Y SK G+ SR LA+ + K +I VN PG V TDM Sbjct: 153 -----------SVYSASKGGLVGFSRALAKEVARK----KIRVNVVAPGFVHTDM 192 >1AE1-A nrPDB Length = 273 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 44/151 (29%), Positives = 70/151 (46%), Gaps = 12/151 (7%) Query: 8 ALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDL 67 ALVTG ++GIG AI EL V +R+ ++ + +GL+ + + DL Sbjct: 24 ALVTGGSKGIGYAIVEELA-GLGARVYTCSRNEKELDECLEIWREKGLNV---EGSVCDL 79 Query: 68 QSIRALRDFLRKEY-----GGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 S R RD L + G LN+LVNNA V + + + + TNF A ++ Sbjct: 80 LS-RTERDKLMQTVAHVFDGKLNILVNNAGVVIHKEAKDFTEKDYNIIMGTNFEAAYHLS 138 Query: 123 NELLPIMKP--HGRVVNISSLQCLRAFENCS 151 P++K +G V+ +SS+ A + S Sbjct: 139 QIAYPLLKASQNGNVIFLSSIAGFSALPSVS 169 >4NBT-A nrPDB Length = 240 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 49/237 (20%), Positives = 88/237 (37%), Gaps = 63/237 (26%) Query: 5 SRVALVTGANRGIG----LAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 +VA++TG +G+G LA A E + +GD+ G EG+ Sbjct: 6 GKVAVITGGAKGLGQAIALAYAEEGAKVIAGDL---------GDLTYSHPNVEGM----- 51 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 L++ D+ + + +YG +++LVNNA + + + + + + N N Sbjct: 52 YLNVTDVTGVEKFYQSVIDKYGKIDILVNNAGITKDAMTRKMTEAQWDAVIDVNLKGVFN 111 Query: 121 MCNELLPIMKP--HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + + P M+ +G ++NISS + F N + Sbjct: 112 LTRLVGPQMQTNGYGSIINISS--VVGVFGNIGQ-------------------------- 143 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 + Y +K GV L+ A+ K + VNA PG + TD+ Sbjct: 144 -------------ANYAATKAGVIGLTMTWAKEF--ALKGANVRVNAIAPGYIMTDI 185 >5T5Q-A nrPDB Length = 247 Score = 44.7 bits (104), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 57/240 (23%), Positives = 87/240 (36%), Gaps = 68/240 (28%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSP------RF 59 R ++TGAN GIG AIA EL ++VLT D + + A SP + Sbjct: 10 RTLVLTGANGGIGRAIA-ELFHASGANLVLTDLD----REGLDAFAASLGSPERIATIKA 64 Query: 60 HQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPF----DIKAEMTLKTNF 115 DD + AL + +GG++ LV +A + PF D T+ N Sbjct: 65 DASSADDAEKTVALA---MERFGGIDFLVPSAGIY----QAKPFAEMSDADWHRTISINL 117 Query: 116 FATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKF 175 +C LP +K +V ++SL R Sbjct: 118 DGVFYLCKRALPALKEDSSIVTLASLAAYRG----------------------------- 148 Query: 176 VEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 + N+ YG +K + ++R L+R L K + VN PG ++T M Sbjct: 149 ------------AYVNAHYGATKGAMVSMTRALSRELAPKTR-----VNGVSPGIIETPM 191 >2GDZ-A nrPDB Length = 267 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 50/151 (33%), Positives = 70/151 (46%), Gaps = 24/151 (15%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARG---QAAVQQLQAEGLSPRFHQ 61 +VALVTGA +GIG A A L + V L ++ G +AA+ + Q E F Q Sbjct: 7 GKVALVTGAAQGIGRAFAEALLLK-GAKVALVDWNLEAGVQCKAALHE-QFEPQKTLFIQ 64 Query: 62 LDIDDLQSIRALRDFLRK---EYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFAT 118 D+ D Q LRD RK +G L++LVNNA V + + E TL+ N + Sbjct: 65 CDVADQQQ---LRDTFRKVVDHFGRLDILVNNAGVNNEKN--------WEKTLQINLVSV 113 Query: 119 RNMCNELLPIMKPH-----GRVVNISSLQCL 144 + L M G ++N+SSL L Sbjct: 114 ISGTYLGLDYMSKQNGGEGGIIINMSSLAGL 144 >1UZM-A nrPDB Length = 247 Score = 44.3 bits (103), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 58/232 (25%), Positives = 85/232 (36%), Gaps = 55/232 (23%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 SR LVTG NRGIGLAIA+ L G V RG A + L ++D Sbjct: 14 VSRSVLVTGGNRGIGLAIAQRLAAD--GHKVAVTH---RGSGAPKGLFGV-------EVD 61 Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCN 123 + D ++ + + G + VLV+NA L + F R M Sbjct: 62 VTDSDAVDRAFTAVEEHQGPVEVLVSNAG------------------LSADAFLMR-MTE 102 Query: 124 ELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEV 183 E +V+N + R + S +Q + G + L N+ Sbjct: 103 EKFE------KVINANLTGAFRVAQRASRSMQRNKFGRMIFIGSVSGLW-----GIGNQA 151 Query: 184 HEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 + Y SK GV ++R +AR L + + N PG + TDM Sbjct: 152 N---------YAASKAGVIGMARSIARELSKA----NVTANVVAPGYIDTDM 190 >1DOH-A nrPDB Length = 283 Score = 44.3 bits (103), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 54/235 (22%), Positives = 90/235 (38%), Gaps = 52/235 (22%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 +VALVTGA RGIG +A EL R+ +V A + V ++ G + ++ Sbjct: 29 GKVALVTGAGRGIGREMAMELGRRGCKVIVNYANSTESAEEVVAAIKKNGSDAACVKANV 88 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVA----FKSDDPMPFDIKAEMTLKTNFFATRN 120 ++ I + + K +G L+++ +N+ V K P FD + + FF R Sbjct: 89 GVVEDIVRMFEEAVKIFGKLDIVCSNSGVVSFGHVKDVTPEEFDRVFTINTRGQFFVAR- 147 Query: 121 MCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 E ++ GR++ + S+ G + K V Sbjct: 148 ---EAYKHLEIGGRLILMGSIT-----------------------GQAKAVPKHAV---- 177 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 Y SK + +R +A + +K +I VN PG +KTDM Sbjct: 178 -------------YSGSKGAIETFARCMAIDMADK----KITVNVVAPGGIKTDM 215 >4IIN-A nrPDB Length = 271 Score = 44.3 bits (103), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 59/251 (23%), Positives = 98/251 (39%), Gaps = 59/251 (23%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQ-QLQAEGLSPRF 59 M + L+TGA++GIG IA+ L V + R A A++ +L+ +G Sbjct: 25 MQFTGKNVLITGASKGIGAEIAKTLA-SMGLKVWINYRSNAEVADALKNELEEKGYKAAV 83 Query: 60 HQLD-IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAE---MTLKTNF 115 + D + I A++ ++ + GGL+ LVNNA V D + +K E + N Sbjct: 84 IKFDAASESDFIEAIQTIVQSD-GGLSYLVNNAGVV---RDKLAIKMKTEDFHHVIDNNL 139 Query: 116 FATRNMCNELLPIMKP--HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMK 173 + C E L +M G VVN++S+ Sbjct: 140 TSAFIGCREALKVMSKSRFGSVVNVASI-------------------------------- 167 Query: 174 KFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKT 233 + ER + Y SK G+ +S+ A + I N+ PG ++T Sbjct: 168 ---------IGERGNMGQTNYSASKGGMIAMSKSFAY----EGALRNIRFNSVTPGFIET 214 Query: 234 DMDG--KDSIR 242 DM+ KD ++ Sbjct: 215 DMNANLKDELK 225 >1AHH-A nrPDB Length = 255 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 38/142 (26%), Positives = 64/142 (45%), Gaps = 10/142 (7%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 + A++TGA GIG IA VV++ + V ++Q G + DI Sbjct: 11 GKCAIITGAGAGIGKEIAITFATA-GASVVVSDINADAANHVVDEIQQLGGQAFACRCDI 69 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKA---EMTLKTNFFATRNM 121 Q + AL DF + G +++LVNNA P PFD+ + N F+ ++ Sbjct: 70 TSEQELSALADFAISKLGKVDILVNNAG----GGGPKPFDMPMADFRRAYELNVFSFFHL 125 Query: 122 CNELLPIMKPHGR--VVNISSL 141 + P M+ +G ++ I+S+ Sbjct: 126 SQLVAPEMEKNGGGVILTITSM 147 >4KMS-A nrPDB Length = 249 Score = 43.9 bits (102), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 56/240 (23%), Positives = 99/240 (41%), Gaps = 61/240 (25%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPR-FHQLD 63 S +A+VTG RGIG A A EL + + + A + AA + + G+ + ++ D Sbjct: 10 SEIAIVTGGTRGIGKATALELKNK---GLTVVANFFSNYDAAKEMEEKYGIKTKCWNVAD 66 Query: 64 IDDL-QSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAE---MTLKTNFFATR 119 ++ Q+++ + + +K +++LVNNA + + D M + + + N + Sbjct: 67 FEECRQAVKEIEEEFKKP---VSILVNNAGI---TKDKMLHRMSHQDWNDVINVNLNSCF 120 Query: 120 NMCNELLPIMKP--HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 NM + ++ M+ +GR+VNISS+ Sbjct: 121 NMSSSVMEQMRNQDYGRIVNISSI------------------------------------ 144 Query: 178 DTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDG 237 N + G N Y +K G+ ++ LAR K I VN PG + T+M G Sbjct: 145 ---NAQAGQVGQTN--YSAAKAGIIGFTKALARETASK----NITVNCIAPGYIATEMVG 195 >2NM0-A nrPDB Length = 253 Score = 43.9 bits (102), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 68/244 (27%), Positives = 86/244 (35%), Gaps = 75/244 (30%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGD-VVLTAR--DVARGQAAVQQLQAEGLSPR 58 S SR LVTG NRGIGLAIAR +GD V +T R + G AV Sbjct: 18 SHMSRSVLVTGGNRGIGLAIARAFAD--AGDKVAITYRSGEPPEGFLAV----------- 64 Query: 59 FHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVA-------FKSDDPMPFDIKAEMTL 111 + DI D + + + + +G + VL+ NA V +D F E L Sbjct: 65 --KCDITDTEQVEQAYKEIEETHGPVEVLIANAGVTKDQLLMRMSEED---FTSVVETNL 119 Query: 112 KTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDL 171 F + +L K GRVV ISS+ L Sbjct: 120 TGTFRVVKRANRAMLRAKK--GRVVLISSVVGLLG------------------------- 152 Query: 172 MKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPV 231 G N Y SK G+ +R LAR L + I N PG V Sbjct: 153 --------------SAGQAN--YAASKAGLVGFARSLARELGSR----NITFNVVAPGFV 192 Query: 232 KTDM 235 TDM Sbjct: 193 DTDM 196 >6CI9-A nrPDB Length = 259 Score = 43.9 bits (102), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 61/237 (25%), Positives = 92/237 (38%), Gaps = 57/237 (24%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTAR---DVARGQAAVQQLQAEGLSPRFHQ 61 R A+VTG ++GIG IA DVV+T R D+ R A + + + + R Sbjct: 9 GRSAIVTGGSKGIGRGIAETFANAGV-DVVITGRNQDDLDRTVADLSGTRGKVTAVRADV 67 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAV--AFKSDDPMPFDIKAEMTLKTNFFATR 119 D +D + R + + + + +GGL+++ NA + + + +D P DI E L NF T Sbjct: 68 TDPEDAR--RTVAETVSR-HGGLDIVCANAGIFPSGRLEDLTPDDI--EQVLGVNFKGTV 122 Query: 120 NMCNELLPIMKP--HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 + L + HGRVV SS+ Sbjct: 123 YIVQAALQALTASGHGRVVVTSSI------------------------------------ 146 Query: 178 DTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD 234 + GW S YG SK R A L K +I +NA PG + T+ Sbjct: 147 --TGPITGYPGW--SHYGASKAAQLGFLRTAAMELAPK----KITINAVLPGNIMTE 195 >4Z9Y-A nrPDB Length = 253 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 37/150 (24%), Positives = 77/150 (51%), Gaps = 16/150 (10%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 +VAL+TG + G+G +A L Q D+V ++ + ++++ A L RF L Sbjct: 10 GKVALITGCDTGLGQGMAIGLA-QAGCDIV--GVNIVEPKDTIEKVTA--LGRRFLSLTA 64 Query: 65 DDLQSIRALRDFLRK---EYGGLNVLVNNAAVAFKSDDPMPFDIK-----AEMTLKTNFF 116 D + ++ + + K E+G +++LVNNA + + +D + F K + +K+ FF Sbjct: 65 D-MSNVSGHAELVEKAVAEFGHVDILVNNAGI-IRREDAIEFSEKNWDDVMNLNIKSVFF 122 Query: 117 ATRNMCNELLPIMKPHGRVVNISSLQCLRA 146 ++ + + + K G+++NI+S+ + Sbjct: 123 MSQTVARQFIKQGKG-GKIINIASMLSFQG 151 >2AE2-A nrPDB Length = 260 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 37/138 (26%), Positives = 58/138 (42%), Gaps = 4/138 (2%) Query: 8 ALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDL 67 ALVTG +RGIG I EL V +R+ + Q +++G D+ Sbjct: 12 ALVTGGSRGIGYGIVEELA-SLGASVYTCSRNQKELNDCLTQWRSKGFKVEASVCDLSSR 70 Query: 68 QSIRALRDFLRKEY-GGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELL 126 + L + + + G LN+LVNNA + + + + NF A ++ Sbjct: 71 SERQELMNTVANHFHGKLNILVNNAGIVIYKEAKDYTVEDYSLIMSINFEAAYHLSVLAH 130 Query: 127 PIMKP--HGRVVNISSLQ 142 P +K G VV ISS+ Sbjct: 131 PFLKASERGNVVFISSVS 148 >3EZL-A nrPDB Length = 256 Score = 43.1 bits (100), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 37/145 (25%), Positives = 66/145 (45%), Gaps = 6/145 (4%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M R+A VTG GIG +I + L + V + R ++ +A G Sbjct: 9 MVMSQRIAYVTGGMGGIGTSICQRLHKDGFRVVAGCGPNSPRRVKWLEDQKALGFDFYAS 68 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAA----VAFKSDDPMPFDIKAEMTLKTNFF 116 + ++ D S + D ++ E G ++VLVNNA V F+ + + L + F Sbjct: 69 EGNVGDWDSTKQAFDKVKAEVGEIDVLVNNAGITRDVVFRKMTREDWQAVIDTNLTSLFN 128 Query: 117 ATRNMCNELLPIMKPHGRVVNISSL 141 T+ + + ++ + GR++NISS+ Sbjct: 129 VTKQVIDGMVE--RGWGRIINISSV 151 >3R3S-A nrPDB Length = 294 Score = 43.1 bits (100), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 67/264 (25%), Positives = 101/264 (38%), Gaps = 62/264 (23%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE----GLSPRFHQ 61 R ALVTG + GIG A A R+ DV + A QQ++A G Sbjct: 50 RKALVTGGDSGIGRAAAIAYARE-GADVAINYLPAEEEDA--QQVKALIEECGRKAVLLP 106 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDD-PMPFDIKAE---MTLKTNFFA 117 D+ D R+L R+ GGL++L A VA K P D+ +E T N FA Sbjct: 107 GDLSDESFARSLVHKAREALGGLDIL---ALVAGKQTAIPEIKDLTSEQFQQTFAVNVFA 163 Query: 118 TRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 + E +P++ ++ SS+Q + + L+D Sbjct: 164 LFWITQEAIPLLPKGASIITTSSIQAYQPSPH------------------LLD------- 198 Query: 178 DTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMD- 236 Y +K + SR LA+++ EK I VN PGP+ T + Sbjct: 199 ----------------YAATKAAILNYSRGLAKQVAEK----GIRVNIVAPGPIWTALQI 238 Query: 237 --GKDSIRTVEEGAETPVYLALLP 258 G+ + + G +TP+ A P Sbjct: 239 SGGQTQDKIPQFGQQTPMKRAGQP 262 >4M8S-A nrPDB Length = 248 Score = 43.1 bits (100), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 61/239 (25%), Positives = 101/239 (42%), Gaps = 60/239 (25%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 ++ALVTGA+RGIG AIA L V+ TA + A ++L G R L+ Sbjct: 7 SGKIALVTGASRGIGAAIADTLAAA-GAKVIGTATSESGAAAISERLAQWGGEGRV--LN 63 Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAE-------MTLKTNFF 116 + +++ L + K +G L++LVNNA + + D + +K E + LK+ F Sbjct: 64 SAEPETVENLIADIEKTFGKLDILVNNAGI---TRDNLLMRMKEEEWDDIMQVNLKSVFR 120 Query: 117 ATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFV 176 A++ + ++ + GR++NI+S +V +M Sbjct: 121 ASKAVLRGMMK--QRAGRIINITS---------------------------VVGVMGN-- 149 Query: 177 EDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 G N Y +K G+ S+ +AR + + I VN PG + TDM Sbjct: 150 ----------AGQTN--YAAAKAGLIGFSKSMAREVGSR----GITVNCVAPGFIDTDM 192 >1HXH-A nrPDB Length = 253 Score = 42.7 bits (99), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 46/181 (25%), Positives = 74/181 (40%), Gaps = 7/181 (3%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE-GLSPRFHQLDI 64 +VALVTG G+GL + + L + + D+ +AA QQL AE G F + D+ Sbjct: 7 KVALVTGGASGVGLEVVKLLLGE---GAKVAFSDI--NEAAGQQLAAELGERSMFVRHDV 61 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE 124 + +++ G LNVLVNNA + D LK N + C + Sbjct: 62 SSEADWTLVMAAVQRRLGTLNVLVNNAGILLPGDMETGRLEDFSRLLKINTESVFIGCQQ 121 Query: 125 LLPIMK-PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEV 183 + MK G ++N++S+ E + + LT + K+ N + Sbjct: 122 GIAAMKETGGSIINMASVSSWLPIEQYAGYSASKAAVSALTRAAALSCRKQGYAIRVNSI 181 Query: 184 H 184 H Sbjct: 182 H 182 >2B4Q-A nrPDB Length = 276 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 43/154 (27%), Positives = 68/154 (44%), Gaps = 10/154 (6%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 S R+ALVTG +RGIG IA+ L + V + ARD +L A G Sbjct: 25 FSLAGRIALVTGGSRGIGQMIAQGLL-EAGARVFICARDAEACADTATRLSAYGDCQAI- 82 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSD-DPMPFDIKAEMTLKTNFFATR 119 D+ R L L + L++LVNNA ++ + + P E ++ N + Sbjct: 83 PADLSSEAGARRLAQALGELSARLDILVNNAGTSWGAALESYPVS-GWEKVMQLNVTSVF 141 Query: 120 NMCNELLPIMKPH------GRVVNISSLQCLRAF 147 + +LLP+++ RV+NI S+ + A Sbjct: 142 SCIQQLLPLLRRSASAENPARVINIGSVAGISAM 175 >4E6P-A nrPDB Length = 259 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/178 (26%), Positives = 79/178 (44%), Gaps = 19/178 (10%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 + AL+TG+ RGIG A A R+ V + D+ R + A ++ G + Q+D+ Sbjct: 8 GKSALITGSARGIGRAFAEAYVRE-GATVAIADIDIERARQAAAEI---GPAAYAVQMDV 63 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAA---------VAFKSDDPMPFDIKAEMTLKTNF 115 SI A + GGL++LVNNAA + +S + + F I TL T Sbjct: 64 TRQDSIDAAIAATVEHAGGLDILVNNAALFDLAPIVEITRESYEKL-FAINVAGTLFTLQ 122 Query: 116 FATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMK 173 A R M + G+++N++S R + + +LT+ +DL+K Sbjct: 123 AAARQMIAQ-----GRGGKIINMASQAGRRGEALVAIYCATKAAVISLTQSAGLDLIK 175 >1NFF-A nrPDB Length = 260 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 41/170 (24%), Positives = 68/170 (40%), Gaps = 6/170 (3%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 +VALV+G RG+G + R + + + V D + + R+ LD Sbjct: 6 TGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILD----EEGKAMAAELADAARYVHLD 61 Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCN 123 + +A D +GGL+VLVNNA + + + L N Sbjct: 62 VTQPAQWKAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIR 121 Query: 124 ELLPIMKPHGR--VVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDL 171 ++ MK GR ++NISS++ L C +F LT+ ++L Sbjct: 122 AVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAVRGLTKSTALEL 171 >4RZH-A nrPDB Length = 247 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 57/239 (23%), Positives = 93/239 (38%), Gaps = 57/239 (23%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 ++VALVTGA+RGIG A A L VV A+ A V ++ A G Q + Sbjct: 5 TAQVALVTGASRGIGKATALALAATGMKVVVNYAQSSTAADAVVAEIIANGGEAIAVQAN 64 Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAE-------MTLKTNFF 116 + + + L ++ ++VLVNNA + + D + +K E + L F Sbjct: 65 VANADEVDQLIKTTLDKFSRIDVLVNNAGI---TRDTLLLRMKLEDWQAVIDLNLTGVFL 121 Query: 117 ATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFV 176 T+ + +L + GR++NI+S+ + Sbjct: 122 CTKAVSKLMLK--QKSGRIINITSVAGMMG------------------------------ 149 Query: 177 EDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 G N Y +K GV ++ +A+ L + + VNA PG + TDM Sbjct: 150 ---------NPGQAN--YSAAKAGVIGFTKTVAKELASR----GVTVNAVAPGFIATDM 193 >4NBV-A nrPDB Length = 246 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 63/268 (23%), Positives = 98/268 (36%), Gaps = 56/268 (20%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 RVA++TGA GIG A A+ VVL AR + A +L A G + +++D+ Sbjct: 5 GRVAIITGAAAGIGFATAQRFAED-GAIVVLCDVQEARVREAAARLAATGATVSAYRVDV 63 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE 124 + A+ + + +++LVNNA + + + + + + N N Sbjct: 64 TRRDEVDAMVAAVLAAHQRVDILVNNAGITKDARLAKMTEAQFDAVIDVNLKGVFNCAQA 123 Query: 125 LLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVH 184 + +M G+ V L +V L F Sbjct: 124 VAGLMTEQGKGV-------------------------ILNASSVVGLYGNF--------- 149 Query: 185 EREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD---------M 235 + Y SK GV ++ AR L K + VNA CPG V T+ + Sbjct: 150 -----GQTNYAASKFGVIGFTKTWARELGPK----GVRVNAVCPGFVNTEILQTVPDKVL 200 Query: 236 DGKDS---IRTVEEGAETPVYLALLPPD 260 DG S +R + E AE A L D Sbjct: 201 DGMTSSCWLRRLAEPAEIASIYAFLASD 228 >4AVY-A nrPDB Length = 242 Score = 42.4 bits (98), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 65/238 (27%), Positives = 98/238 (41%), Gaps = 45/238 (18%) Query: 9 LVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGL-SPRF-----HQL 62 LVTG + GIG AIA + L A VA G L A+G+ +PR +L Sbjct: 15 LVTGGSSGIGAAIAMQFAE-------LGAEVVALG------LDADGVHAPRHPRIRREEL 61 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKA-EMTLKTNFFATRNM 121 DI D Q ++ L + L + L+VLVNNA + S D +D+ E L+ N A Sbjct: 62 DITDSQRLQRLFEALPR----LDVLVNNAGI---SRDREEYDLATFERVLRLNLSAAMLA 114 Query: 122 CNELLPIMKPH-GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 P++ G ++NI+S+ F + + + ++G +V L + + Sbjct: 115 SQLARPLLAQRGGSILNIASMYS--TFGSADRP------AYSASKGAIVQLTRSLACEYA 166 Query: 181 NEVHE----REGWPNSPYGVS-KLGVTVLSRILAR----RLDEKRKADRILVNACCPG 229 E GW ++P G K V RI+ R R E + C PG Sbjct: 167 AERIRVNAIAPGWIDTPLGAGLKADVEATRRIMQRTPLARWGEAPEVASAAAFLCGPG 224 >4DA9-A nrPDB Length = 280 Score = 42.4 bits (98), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 50/147 (34%), Positives = 73/147 (49%), Gaps = 11/147 (7%) Query: 7 VALVTGANRGIGLAIARELCRQFSG-DVVLTARDVARGQA-AVQQLQAEGLSPRFHQLDI 64 VA+VTG RGIGL IAR L SG D+ +T A G A + +L G F + D+ Sbjct: 31 VAIVTGGRRGIGLGIARALAA--SGFDIAITGIGDAEGVAPVIAELSGLGARVIFLRADL 88 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVA------FKSDDPMPFDIKAEMTLKTNFFAT 118 DL S +A D + E+G ++ LVNNA +A F P FD + L+ F T Sbjct: 89 ADLSSHQATVDAVVAEFGRIDCLVNNAGIASIVRDDFLDLKPENFDTIVGVNLRGTVFFT 148 Query: 119 RNMCNELLPIMKPHGR-VVNISSLQCL 144 + + +L R ++NI+S+ + Sbjct: 149 QAVLKAMLASDARASRSIINITSVSAV 175 >3T7C-A nrPDB Length = 299 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 47/173 (27%), Positives = 79/173 (45%), Gaps = 25/173 (14%) Query: 5 SRVALVTGANRGIG----LAIARE--------LCRQFSGDVVL---TARDVARGQAAVQQ 49 +VA +TGA RG G + +ARE +C+Q G V L T D+A V+Q Sbjct: 28 GKVAFITGAARGQGRSHAITLAREGADIIAIDVCKQLDG-VKLPMSTPDDLAE---TVRQ 83 Query: 50 LQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSD-----DPMPFD 104 ++A G Q+D+ D +++A D + G L++++ NAA+A + DP + Sbjct: 84 VEALGRRIIASQVDVRDFDAMQAAVDDGVTQLGRLDIVLANAALASEGTRLNRMDPKTWR 143 Query: 105 IKAEMTLKTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQER 157 ++ L + R ++ K G +V SS+ LR EN + + Sbjct: 144 DMIDVNLNGAWITARVAIPHIMA-GKRGGSIVFTSSIGGLRGAENIGNYIASK 195 >4JRO-A nrPDB Length = 271 Score = 41.6 bits (96), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 58/259 (22%), Positives = 104/259 (40%), Gaps = 71/259 (27%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M+ +VA+VTG +RGIG IA L ++ ++ +L AE H Sbjct: 25 MTLQGKVAVVTGGSRGIGRDIAINLAKE-GANIFFNYNGSPEAAEETAKLVAE------H 77 Query: 61 QLDIDDLQSIRALRD----FLRK---EYGGLNVLVNNAAVA-------FKSDDPMPFDIK 106 ++++ +++ A+ + F ++ +G +++LVNNA + K D+ +D Sbjct: 78 GVEVEAMKANVAIAEDVDAFFKQAIERFGRVDILVNNAGITRDNLLMRMKEDE---WDDV 134 Query: 107 AEMTLKTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEG 166 + LK F T+ + ++ + G+++N++S+ L N + Sbjct: 135 ININLKGTFLCTKAVSRTMMK--QRAGKIINMASVVGL--IGNAGQ-------------- 176 Query: 167 DLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNAC 226 + Y SK GV L++ AR L + I VNA Sbjct: 177 -------------------------ANYVASKAGVIGLTKTTARELAPR----GINVNAV 207 Query: 227 CPGPVKTDMDGKDSIRTVE 245 PG + TDM K +T E Sbjct: 208 APGFITTDMTDKLDEKTKE 226 >3A28-C nrPDB Length = 258 Score = 41.6 bits (96), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 30/93 (32%), Positives = 48/93 (51%), Gaps = 3/93 (3%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAA--VQQLQAEGLSPRFHQ 61 S+VA+VTG +GIG I+ +L D+ + QAA ++ ++A F Sbjct: 1 MSKVAMVTGGAQGIGRGISEKLAAD-GFDIAVADLPQQEEQAAETIKLIEAADQKAVFVG 59 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVA 94 LD+ D + + D ++ GG +VLVNNA +A Sbjct: 60 LDVTDKANFDSAIDEAAEKLGGFDVLVNNAGIA 92 >5VT6-A nrPDB Length = 269 Score = 40.8 bits (94), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 36/146 (24%), Positives = 64/146 (43%), Gaps = 8/146 (5%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE---GLSPRFHQL 62 RVA VTG G+G AI+R L + + R L E G + + + Sbjct: 26 RVAFVTGGMGGLGAAISRRL---HDAGMAVAVSHSERNDHVSTWLMHERDAGRDFKAYAV 82 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 D+ D +S + + ++G ++VL+NNA + + + ++T+ A N+ Sbjct: 83 DVADFESCERCAEKVLADFGKVDVLINNAGITRDATFMKMTKGDWDAVMRTDLDAMFNVT 142 Query: 123 NELLPIM--KPHGRVVNISSLQCLRA 146 + + M + GR+VNI S+ R Sbjct: 143 KQFIAGMVERRFGRIVNIGSVNGSRG 168 >6CGE-A nrPDB Length = 328 Score = 40.8 bits (94), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 52/173 (30%), Positives = 69/173 (39%), Gaps = 9/173 (5%) Query: 7 VALVTGANRGIGLAIARELCRQFSGD--VVLTARDV---ARGQAAVQQLQAEGLSPRFHQ 61 V L+TG + GIGL +A L S V T RD+ R A + L S Q Sbjct: 5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQ 64 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 LD+ D +S+ A R+ R G ++VLV NA + + L N T M Sbjct: 65 LDVRDSKSVAAARE--RVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRM 122 Query: 122 CNELLPIMK--PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLM 172 LP MK GRV+ S+ L +F E L E V L+ Sbjct: 123 LQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLL 175 >1A27-A nrPDB Length = 289 Score = 40.4 bits (93), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 52/173 (30%), Positives = 69/173 (39%), Gaps = 9/173 (5%) Query: 7 VALVTGANRGIGLAIARELCRQFSGD--VVLTARDV---ARGQAAVQQLQAEGLSPRFHQ 61 V L+TG + GIGL +A L S V T RD+ R A + L S Q Sbjct: 4 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQ 63 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 LD+ D +S+ A R+ R G ++VLV NA + + L N T M Sbjct: 64 LDVRDSKSVAAARE--RVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRM 121 Query: 122 CNELLPIMK--PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLM 172 LP MK GRV+ S+ L +F E L E V L+ Sbjct: 122 LQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLL 174 >3AUT-A nrPDB Length = 269 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 50/232 (21%), Positives = 97/232 (41%), Gaps = 44/232 (18%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 +V ++TG + G+G A+A ++ + V+ + A ++++ G Q D+ Sbjct: 16 KVVVITGGSTGLGRAMAVRFGQEEAKVVINYYNNEEEALDAKKEVEEAGGQAIIVQGDVT 75 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNEL 125 + + L KE+G L+V++NNA V ++P+P E++L N++ Sbjct: 76 KEEDVVNLVQTAIKEFGTLDVMINNAGV----ENPVP---SHELSLDN--------WNKV 120 Query: 126 LPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHE 185 + AF E + ++ E +G+++++ + VHE Sbjct: 121 I-------------DTNLTGAFLGSREAI--KYFVENDIKGNVINM---------SSVHE 156 Query: 186 REGWP-NSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMD 236 WP Y SK G+ +++ LA K I VN PG + T ++ Sbjct: 157 MIPWPLFVHYAASKGGMKLMTETLALEYAPK----GIRVNNIGPGAMNTPIN 204 >2PH3-A nrPDB Length = 245 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 43/143 (30%), Positives = 68/143 (47%), Gaps = 11/143 (7%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 R AL+TGA+RGIG AIA L + ++ + + ++ + G SP L + Sbjct: 2 RKALITGASRGIGRAIALRLAEDGFALAIHYGQNREKAEEVAEEARRRG-SPLVAVLGAN 60 Query: 66 DL--QSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIK---AEMTLKTNFFATRN 120 L ++ AL + GGL+ LVNNA + + D + +K E L+ N A Sbjct: 61 LLEAEAATALVHQAAEVLGGLDTLVNNAGI---TRDTLLVRMKDEDWEAVLEANLSAVFR 117 Query: 121 MCNELLPIMKP--HGRVVNISSL 141 E + +M GR+VNI+S+ Sbjct: 118 TTREAVKLMMKARFGRIVNITSV 140 >3UF0-A nrPDB Length = 273 Score = 38.1 bits (87), Expect = 0.004, Method: Compositional matrix adjust. Identities = 55/226 (24%), Positives = 87/226 (38%), Gaps = 31/226 (13%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 S R A+VTGA GIG AIA R +G VL + ++ G S Sbjct: 27 FSLAGRTAVVTGAGSGIGRAIAHGYAR--AGAHVLAWGRTDGVKEVADEIADGGGSAEAV 84 Query: 61 QLDIDDLQSIRALRDFL---RKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFA 117 D+ DL+ + + L R+ ++VLVNNA + ++ + L N A Sbjct: 85 VADLADLEGAANVAEELAATRR----VDVLVNNAGIIARAPAEEVSLGRWREVLTVNLDA 140 Query: 118 TRNMCNELLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKF 175 + M H GR+V I+S+ + N + + H+ +V L + Sbjct: 141 AWVLSRSFGTAMLAHGSGRIVTIASMLSFQGGRNVAAYAASK-HA-------VVGLTRAL 192 Query: 176 VEDTKNEVHEREGWPNSPYGVSKL--GVTVLSRILARRLDEKRKAD 219 + W GV+ L G V + A R D++R A+ Sbjct: 193 ASE----------WAGRGVGVNALAPGYVVTANTAALRADDERAAE 228 >5PGZ-A nrPDB Length = 276 Score = 38.1 bits (87), Expect = 0.004, Method: Compositional matrix adjust. Identities = 39/139 (28%), Positives = 63/139 (45%), Gaps = 11/139 (7%) Query: 9 LVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQ-LQAEGLSPRFHQLDIDDL 67 +VTGA++GIG +A L + VVLTAR Q V + L+ S + ++D+ Sbjct: 22 IVTGASKGIGREMAYHLSKM-GAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDM 80 Query: 68 QSIRALRDFLRKEYGGLNVLVNN----AAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCN 123 K GGL++L+ N +++ DD ++ NF + M Sbjct: 81 TFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIH----SVRRVMEVNFLSYVVMST 136 Query: 124 ELLPIMK-PHGRVVNISSL 141 LP++K +G + ISSL Sbjct: 137 AALPMLKQSNGSIAVISSL 155 >4EGF-A nrPDB Length = 266 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 38/111 (34%), Positives = 55/111 (49%), Gaps = 8/111 (7%) Query: 8 ALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID-- 65 AL+TGA +GIG IAR + +VL+ RDV+ AA + L E H + ID Sbjct: 23 ALITGATKGIGADIARAFAAAGA-RLVLSGRDVSELDAARRAL-GEQFGTDVHTVAIDLA 80 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAVAFKS----DDPMPFDIKAEMTLK 112 + + L + +GGL+VLVNNA ++ DP FD + L+ Sbjct: 81 EPDAPAELARRAAEAFGGLDVLVNNAGISHPQPVVDTDPQLFDATIAVNLR 131 >3D3W-A nrPDB Length = 244 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 50/153 (32%), Positives = 72/153 (47%), Gaps = 20/153 (13%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE--GLSPRFHQLD 63 R LVTGA +GIG + L +G V+ V+R QA + L E G+ P +D Sbjct: 8 RRVLVTGAGKGIGRGTVQAL--HATGARVVA---VSRTQADLDSLVRECPGIEPVC--VD 60 Query: 64 IDDLQSI-RALRDFLRKEYGGLNVLVNNAAVA----FKSDDPMPFDIKAEMTLKTNFFAT 118 + D ++ RAL G +++LVNNAAVA F FD E+ L+ + Sbjct: 61 LGDWEATERAL-----GSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 Query: 119 RNMCNELLPIMKPHGRVVNISSLQCLRAFENCS 151 + + L+ P G +VN+SS RA N S Sbjct: 116 QIVARGLIARGVP-GAIVNVSSQCSQRAVTNHS 147 >5OVL-A nrPDB Length = 300 Score = 37.4 bits (85), Expect = 0.006, Method: Compositional matrix adjust. Identities = 44/149 (29%), Positives = 63/149 (42%), Gaps = 16/149 (10%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 SR LVTG NRGIGLAIAR L V +T RG A L Q D Sbjct: 67 VSRSVLVTGGNRGIGLAIARRLAAD-GHKVAVT----HRGSGAPDDLFGV-------QCD 114 Query: 64 IDDLQSI-RALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 + D ++ RA ++ + + G + VLV NA ++ + + + E + TN Sbjct: 115 VTDSAAVDRAFKE-VEEHQGPVEVLVANAGISKDAFLMRMTEERFEEVINTNLTGAFRCA 173 Query: 123 NELLPIM--KPHGRVVNISSLQCLRAFEN 149 M K GR++ I S+ + N Sbjct: 174 QRASRTMQRKRFGRIIFIGSVSGMWGIGN 202 >5OVJ-A nrPDB Length = 256 Score = 37.4 bits (85), Expect = 0.007, Method: Compositional matrix adjust. Identities = 44/149 (29%), Positives = 63/149 (42%), Gaps = 16/149 (10%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 SR LVTG NRGIGLAIAR L V +T RG A L Q D Sbjct: 23 VSRSVLVTGGNRGIGLAIARRLAAD-GHKVAVT----HRGSGAPDDLFGV-------QCD 70 Query: 64 IDDLQSI-RALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 + D ++ RA ++ + + G + VLV NA ++ + + + E + TN Sbjct: 71 VTDSAAVDRAFKE-VEEHQGPVEVLVANAGISKDAFLMRMTEERFEEVINTNLTGAFRCA 129 Query: 123 NELLPIM--KPHGRVVNISSLQCLRAFEN 149 M K GR++ I S+ + N Sbjct: 130 QRASRTMQRKRFGRIIFIGSVSGMWGIGN 158 >2EW8-A nrPDB Length = 249 Score = 37.0 bits (84), Expect = 0.009, Method: Compositional matrix adjust. Identities = 38/171 (22%), Positives = 73/171 (42%), Gaps = 7/171 (4%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 ++A++TG GIG AIA + + + +AA++ L L+ + D+ Sbjct: 8 KLAVITGGANGIGRAIAERFAVEGADIAIADLVPAPEAEAAIRNLGRRVLTVK---CDVS 64 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAVA-FKSDDPMPFDIKAEMTLKTNFFATRNMCNE 124 + A + +G ++LVNNA + D + F+ + + T + N + M Sbjct: 65 QPGDVEAFGKQVISTFGRCDILVNNAGIYPLIPFDELTFE-QWKKTFEINVDSGFLMAKA 123 Query: 125 LLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMK 173 +P MK + GR++N++S E + + + + T DL K Sbjct: 124 FVPGMKRNGWGRIINLTSTTYWLKIEAYTHYISTKAANIGFTRALASDLGK 174 >1SNY-A nrPDB Length = 267 Score = 36.6 bits (83), Expect = 0.011, Method: Compositional matrix adjust. Identities = 42/130 (32%), Positives = 61/130 (46%), Gaps = 12/130 (9%) Query: 9 LVTGANRGIGLAIARELCR--QFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDD 66 L+TG NRG+GL + + L Q + T R+ R QA + A+ S H L+I D Sbjct: 25 LITGCNRGLGLGLVKALLNLPQPPQHLFTTCRN--REQAKELEDLAKNHS-NIHILEI-D 80 Query: 67 LQSIRALRDFLRKEYG-----GLNVLVNNAAVAFKSDDPMPFDIKAEM-TLKTNFFATRN 120 L++ A + G GLNVL NNA +A KS + + TL+TN Sbjct: 81 LRNFDAYDKLVADIEGVTKDQGLNVLFNNAGIAPKSARITAVRSQELLDTLQTNTVVPIM 140 Query: 121 MCNELLPIMK 130 + LP++K Sbjct: 141 LAKACLPLLK 150 >4FC7-A nrPDB Length = 277 Score = 36.2 bits (82), Expect = 0.014, Method: Compositional matrix adjust. Identities = 28/91 (30%), Positives = 46/91 (50%), Gaps = 2/91 (2%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQ-AEGLSPRFHQLDI 64 +VA +TG GIG IA E+ + V+ +R + R A ++L A G +D+ Sbjct: 28 KVAFITGGGSGIGFRIA-EIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSMDV 86 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAF 95 ++ A D KE+G +++L+N AA F Sbjct: 87 RAPPAVMAAVDQALKEFGRIDILINCAAGNF 117 >4HBG-A nrPDB Length = 286 Score = 36.2 bits (82), Expect = 0.015, Method: Compositional matrix adjust. Identities = 46/180 (25%), Positives = 72/180 (40%), Gaps = 46/180 (25%) Query: 7 VALVTGANRGIGLAIARELCRQFSGDVVL--TARDVARGQAAVQQLQAEGLSPRF----- 59 VA+VTGA RGIG AI ++L ++ ++L T + R QLQ+ GLS + Sbjct: 6 VAIVTGATRGIGKAICQKLFQKGLSCIILGSTKESIERTAIDRGQLQS-GLSYQRQCAIA 64 Query: 60 -------HQLDIDDLQSIRALRDF--LRKEYGGL----------------NVLVNNAAVA 94 H LD + I +D L+++Y L N+L+N A + Sbjct: 65 IDFKKWPHWLDYESYDGIEYFKDRPPLKQKYSTLFDPCNKWSNNERRYYVNLLINCAGLT 124 Query: 95 FKSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIMKPHGR-------------VVNISSL 141 +S + + + NF + M N + M R +VNISS+ Sbjct: 125 QESLSVRTTASQIQDIMNVNFMSPVTMTNICIKYMMKSQRRWPELSGQSARPTIVNISSI 184 >5ILO-A nrPDB Length = 271 Score = 36.2 bits (82), Expect = 0.016, Method: Compositional matrix adjust. Identities = 53/235 (22%), Positives = 87/235 (37%), Gaps = 60/235 (25%) Query: 8 ALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE--GLSPRFHQLDID 65 A+VTG GIGL ++++L + V + D+ +L+A S ++D+ Sbjct: 18 AVVTGGAGGIGLQVSKQLLAAGAAKVAII--DLQDNLEEFVKLRAAHPTQSVMIIKMDVA 75 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNEL 125 + + + A + + K +G ++++VN A + F D + TL N N Sbjct: 76 NKKGVEATYEEIAKTFGNIDIVVNVAGI-FNDKD-------VQRTLLVNLGGIINSTLSA 127 Query: 126 LPIM-----KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 LP M G VVN+SS +V L F+ Sbjct: 128 LPYMGKDNGGKGGIVVNMSS---------------------------VVGLDPMFIIPV- 159 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 YG +K G+ +R LA +R + + CPG TDM Sbjct: 160 -------------YGATKAGIINFTRCLANEKYYQRSGIKFV--TVCPGATMTDM 199 >5JY1-A nrPDB Length = 274 Score = 35.8 bits (81), Expect = 0.020, Method: Compositional matrix adjust. Identities = 33/118 (27%), Positives = 55/118 (46%), Gaps = 15/118 (12%) Query: 33 VVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAA 92 V++ + + G+ Q+++ G F + D+ SI A +++G L++LVNNA Sbjct: 41 VIIAEINESTGRQVEQEIREMGGRSLFVKTDVTSKASIEAAVRSAVEQFGSLDILVNNAF 100 Query: 93 VAFKSDDPMP-------FDIKAEMTLKTNFFAT-RNMCNELLPIM-KPHGRVVNISSL 141 V P P D E TL T+ +AT M +P+ + GR+VN S+ Sbjct: 101 V------PTPNVLLEEKTDEMLEQTLTTSLWATWWAMRAAFVPMRERRWGRIVNFYSI 152 >1K2W-A nrPDB Length = 256 Score = 35.4 bits (80), Expect = 0.029, Method: Compositional matrix adjust. Identities = 35/94 (37%), Positives = 50/94 (53%), Gaps = 14/94 (14%) Query: 5 SRVALVTGANRGIGLAIA----RELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 + AL+TG+ RGIG A A RE R D+ L A AR AA A ++ Sbjct: 5 GKTALITGSARGIGRAFAEAYVREGARVAIADINLEA---ARATAAEIGPAACAIA---- 57 Query: 61 QLDIDDLQSI-RALRDFLRKEYGGLNVLVNNAAV 93 LD+ D SI R + + L + +G +++LVNNAA+ Sbjct: 58 -LDVTDQASIDRCVAELLDR-WGSIDILVNNAAL 89 >1CYD-A nrPDB Length = 244 Score = 35.4 bits (80), Expect = 0.031, Method: Compositional matrix adjust. Identities = 47/155 (30%), Positives = 67/155 (43%), Gaps = 32/155 (20%) Query: 8 ALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE--GLSPRFHQLDID 65 ALVTGA +GIG + L SG V+ V R + + L E G+ P +D+ Sbjct: 10 ALVTGAGKGIGRDTVKAL--HASGAKVVA---VTRTNSDLVSLAKECPGIEPVC--VDLG 62 Query: 66 DLQSIRALRDFLRKEYGGL---NVLVNNAAVA----FKSDDPMPFDIKAEMTLKTNF--- 115 D D K GG+ ++LVNNAA+ F FD + L++ F Sbjct: 63 DW-------DATEKALGGIGPVDLLVNNAALVIMQPFLEVTKEAFDRSFSVNLRSVFQVS 115 Query: 116 -FATRNMCNELLPIMKPHGRVVNISSLQCLRAFEN 149 R+M N +P G +VN+SS+ F N Sbjct: 116 QMVARDMINRGVP-----GSIVNVSSMVAHVTFPN 145 >4IS3-A nrPDB Length = 268 Score = 34.7 bits (78), Expect = 0.043, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 46/94 (48%), Gaps = 11/94 (11%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVL--TARDVARGQAAVQQLQAE----GLSPRF 59 +V ++TG RGIG A A+ + + T +V A +++L E G +P Sbjct: 26 KVTIITGGTRGIGFAAAKIFIDNGAKVSIFGETQEEVDTALAQLKELYPEEEVLGFAP-- 83 Query: 60 HQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAV 93 D+ ++ A + ++YG L+V++NNA + Sbjct: 84 ---DLTSRDAVMAAVGQVAQKYGRLDVMINNAGI 114 >5TQV-A nrPDB Length = 233 Score = 34.7 bits (78), Expect = 0.045, Method: Compositional matrix adjust. Identities = 41/134 (30%), Positives = 61/134 (45%), Gaps = 27/134 (20%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGD---VVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 + L+ GA+RG+G RE RQ+ D V+ TARD A++ L+A L H L Sbjct: 10 KTVLIVGASRGLG----REFVRQYQRDGWNVIATARD----DASLAALRA--LGAHAHAL 59 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 DI + I AL L E + V+V+ P ++ T+ ++ F T Sbjct: 60 DITQPEQIAALGWKLDGERLDVAVVVSGVY------GPRTEGVE---TIASDDFDTVMHT 110 Query: 123 N-----ELLPIMKP 131 N +LLPI+ P Sbjct: 111 NVRGPMQLLPILLP 124 >4RZI-B nrPDB Length = 240 Score = 33.9 bits (76), Expect = 0.088, Method: Compositional matrix adjust. Identities = 36/145 (24%), Positives = 61/145 (42%), Gaps = 17/145 (11%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 +V +VTG NRGIG AI + L ++ V T D+A + L ++ Sbjct: 9 KVIVVTGGNRGIGAAIVK-LLQEMGAKVAFT--DLATDGGNTEALGV--------VANVT 57 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAVA----FKSDDPMPFDIKAEMTLKTNFFATRNM 121 DL+S+ A + + G + +V NA + F P +D + LK ++ + Sbjct: 58 DLESMTAAAAEITDKLGPVYGVVANAGITKDNFFPKLTPADWDAVLNVNLKGVAYSIKPF 117 Query: 122 CNELLPIMKPHGRVVNISSLQCLRA 146 + + G +V ISS+ R Sbjct: 118 IEGMYE--RKAGSIVAISSISGERG 140 >2O23-A nrPDB Length = 265 Score = 33.5 bits (75), Expect = 0.090, Method: Compositional matrix adjust. Identities = 26/91 (28%), Positives = 47/91 (51%), Gaps = 4/91 (4%) Query: 7 VALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDD 66 VA++TG G+GLA A L Q + V+L + + G+A ++L G + F D+ Sbjct: 14 VAVITGGASGLGLATAERLVGQGASAVLLDLPN-SGGEAQAKKL---GNNCVFAPADVTS 69 Query: 67 LQSIRALRDFLRKEYGGLNVLVNNAAVAFKS 97 + ++ + ++G ++V VN A +A S Sbjct: 70 EKDVQTALALAKGKFGRVDVAVNCAGIAVAS 100 >3UN1-A nrPDB Length = 260 Score = 33.1 bits (74), Expect = 0.12, Method: Compositional matrix adjust. Identities = 66/264 (25%), Positives = 106/264 (40%), Gaps = 71/264 (26%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M + +V ++TGA++GIG + R R + VV T+R + P H Sbjct: 24 MRNQQKVVVITGASQGIGAGLVRA-YRDRNYRVVATSRSI-----------KPSADPDIH 71 Query: 61 QL--DIDDLQSI-RALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFA 117 + DI ++ R +R+ + + +G ++ LVNNA V PF EMT + Sbjct: 72 TVAGDISKPETADRIVREGIER-FGRIDSLVNNAGVFLAK----PF---VEMTQED---- 119 Query: 118 TRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGD--LVDLMKKF 175 H VN++ F + +R +E L +G +V + Sbjct: 120 ------------YDHNLGVNVAGF-----FH-----ITQRAAAEMLKQGSGHIVSITTSL 157 Query: 176 VEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 V+ G P++ ++K G+ ++R LA ++ R R VNA PG +KT M Sbjct: 158 VD------QPMVGMPSALASLTKGGLNAVTRSLA--MEFSRSGVR--VNAVSPGVIKTPM 207 Query: 236 DGKDSIRTVEEGAETPVYLALLPP 259 AET LA L P Sbjct: 208 ----------HPAETHSTLAGLHP 221 >1OAA-A nrPDB Length = 259 Score = 33.1 bits (74), Expect = 0.13, Method: Compositional matrix adjust. Identities = 45/162 (27%), Positives = 72/162 (44%), Gaps = 23/162 (14%) Query: 7 VALVTGANRGIGLAIARELCRQFS-GDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI- 64 V ++TGA+RG G A+A +L R S G V+L + AR ++ ++QL+ E L + L + Sbjct: 8 VCVLTGASRGFGRALAPQLARLLSPGSVMLVS---ARSESMLRQLKEE-LGAQQPDLKVV 63 Query: 65 ---DDLQS-------IRALRDFLRKEYGGLNVLVNNAAVA-------FKSDDPMPFDIKA 107 DL + + A+R+ R E +L+NNAA +D + Sbjct: 64 LAAADLGTEAGVQRLLSAVRELPRPEGLQRLLLINNAATLGDVSKGFLNVNDLAEVNNYW 123 Query: 108 EMTLKTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFEN 149 + L + T N VVNISSL L+ ++ Sbjct: 124 ALNLTSMLCLTSGTLNAFQDSPGLSKTVVNISSLCALQPYKG 165 >1GEE-A nrPDB Length = 261 Score = 33.1 bits (74), Expect = 0.15, Method: Compositional matrix adjust. Identities = 48/233 (20%), Positives = 95/233 (40%), Gaps = 46/233 (19%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 +V ++TG++ G+G ++A + + VV + +++++ G + D+ Sbjct: 8 KVVVITGSSTGLGKSMAIRFATEKAKVVVNYRSKEDEANSVLEEIKKVGGEAIAVKGDVT 67 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLK-TNFFATRNMCNE 124 + L KE+G L+V++NNA + ++P+ EM+L N N+ Sbjct: 68 VESDVINLVQSAIKEFGKLDVMINNAGL----ENPVS---SHEMSLSDWNKVIDTNLTGA 120 Query: 125 LLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVH 184 L S + ++ F D++ G ++++ + VH Sbjct: 121 FL------------GSREAIKYF--VENDIK----------GTVINM---------SSVH 147 Query: 185 EREGWP-NSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMD 236 E+ WP Y SK G+ +++ LA K I VN PG + T ++ Sbjct: 148 EKIPWPLFVHYAASKGGMKLMTETLALEYAPK----GIRVNNIGPGAINTPIN 196 >3U4C-A nrPDB Length = 281 Score = 32.7 bits (73), Expect = 0.16, Method: Compositional matrix adjust. Identities = 41/144 (28%), Positives = 67/144 (46%), Gaps = 19/144 (13%) Query: 6 RVALVTGANRGIGLAIARELCRQ-FSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL-- 62 R A V GA++GIG AIA +L Q FS +V+ +R++ ++ + + A+ L Sbjct: 24 RTAFVMGASQGIGKAIALKLADQHFS--LVINSRNLDNIESVKEDILAKHPEASVIVLAG 81 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPF------DIKAEMTLKTNFF 116 D+ D + + + + G L+VL+NN P F D+ A T KT Sbjct: 82 DMSDQHTRAGIFQKIESQCGRLDVLINN----IPGGAPDTFDNCNIEDMTATFTQKT--V 135 Query: 117 ATRNMCNELLPIMKPH--GRVVNI 138 A + +MK + GR++NI Sbjct: 136 AYIDAIKRASSLMKQNEFGRIINI 159 >1E3W-A nrPDB Length = 261 Score = 32.3 bits (72), Expect = 0.22, Method: Compositional matrix adjust. Identities = 22/88 (25%), Positives = 47/88 (53%), Gaps = 4/88 (4%) Query: 7 VALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDD 66 VA++TG G+GL+ A+ L Q + V+L + + G+ ++L + F ++ Sbjct: 12 VAVITGGASGLGLSTAKRLVGQGATAVLLDVPN-SEGETEAKKLGGNCI---FAPANVTS 67 Query: 67 LQSIRALRDFLRKEYGGLNVLVNNAAVA 94 + ++A ++++G ++V VN A +A Sbjct: 68 EKEVQAALTLAKEKFGRIDVAVNCAGIA 95 >1H5Q-A nrPDB Length = 265 Score = 32.0 bits (71), Expect = 0.28, Method: Compositional matrix adjust. Identities = 34/153 (22%), Positives = 63/153 (41%), Gaps = 21/153 (13%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE-GLSPRF 59 +S ++ +VTG NRGIGLA R + + V+ R A +++ E G+ + Sbjct: 10 ISFVNKTIIVTGGNRGIGLAFTRAVAAAGANVAVIY-RSAADAVEVTEKVGKEFGVKTKA 68 Query: 60 HQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAF--------KSDDPMPFDIKAEMTL 111 +Q D+ + + + + G ++ L+ NA V+ D +D+ Sbjct: 69 YQCDVSNTDIVTKTIQQIDADLGPISGLIANAGVSVVKPATELTHEDFAFVYDV------ 122 Query: 112 KTNFFATRNMCNELLPIM---KPHGRVVNISSL 141 N F N C + + + G +V SS+ Sbjct: 123 --NVFGVFNTCRAVAKLWLQKQQKGSIVVTSSM 153 >5KOI-A nrPDB Length = 293 Score = 31.2 bits (69), Expect = 0.57, Method: Compositional matrix adjust. Identities = 33/144 (22%), Positives = 66/144 (45%), Gaps = 13/144 (9%) Query: 14 NRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRAL 73 N + IA++L Q ++ T + A G+ V+ L + S D++D+ ++ A+ Sbjct: 39 NHSLAWGIAKQLAAQ-GAELAFTYQGDALGKR-VKPLAEQVGSDFVLPCDVEDIATVDAV 96 Query: 74 RDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNF--------FATRNMCNEL 125 + + K++GGL+ LV+ A+ F SD A++T + NF ++ + Sbjct: 97 FEEIEKKWGGLDFLVH--AIGF-SDKTELKGRYADVTTRENFSRTMVISAYSFTEVAQRA 153 Query: 126 LPIMKPHGRVVNISSLQCLRAFEN 149 +MK G ++ ++ R N Sbjct: 154 EKLMKDGGSILTLTYGGSTRTIPN 177 >3DWF-A nrPDB Length = 276 Score = 30.8 bits (68), Expect = 0.75, Method: Compositional matrix adjust. Identities = 25/83 (30%), Positives = 39/83 (46%), Gaps = 2/83 (2%) Query: 9 LVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQ-LQAEGLSPRFHQLDIDDL 67 +VTGA++GIG IA L + VV+TAR Q V + L+ S + ++D+ Sbjct: 15 IVTGASKGIGREIAYHLAKM-GAHVVVTARSKEALQKVVARCLELGAASAHYIAGSMEDM 73 Query: 68 QSIRALRDFLRKEYGGLNVLVNN 90 GGL++L+ N Sbjct: 74 TFAEEFVAEAGNLMGGLDMLILN 96 >1O5I-A nrPDB Length = 249 Score = 30.4 bits (67), Expect = 0.79, Method: Compositional matrix adjust. Identities = 41/145 (28%), Positives = 62/145 (42%), Gaps = 22/145 (15%) Query: 9 LVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQ 68 LV A+RGIG A+A ++ Q +V + AR+ E L H+ + DL Sbjct: 23 LVLAASRGIGRAVA-DVLSQEGAEVTICARN------------EELLKRSGHRYVVCDL- 68 Query: 69 SIRALRDFLRKEYGGLNVLVNNAA--VAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELL 126 R D L ++ +++LV NA A D+ D K + + F + L Sbjct: 69 --RKDLDLLFEKVKEVDILVLNAGGPKAGFFDELTNEDFKE--AIDSLFLNMIKIVRNYL 124 Query: 127 PIMKPH--GRVVNISSLQCLRAFEN 149 P MK GR+V I+S + EN Sbjct: 125 PAMKEKGWGRIVAITSFSVISPIEN 149 >5B1Y-A nrPDB Length = 270 Score = 30.0 bits (66), Expect = 1.2, Method: Compositional matrix adjust. Identities = 26/88 (29%), Positives = 41/88 (46%), Gaps = 3/88 (3%) Query: 8 ALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH--QLDID 65 ALVTG +RGIG A R+ V+ + ++ + G SP + ++D+ Sbjct: 26 ALVTGGSRGIGRATVLRFAREGWSVVIAYKSRADLAEKTAEEARRLG-SPEAYTVRVDVG 84 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAV 93 D S+ + + + LNVLVN A V Sbjct: 85 DPDSVTEMSSRVGELIPHLNVLVNAAGV 112 >4TRR-A nrPDB Length = 269 Score = 30.0 bits (66), Expect = 1.2, Method: Compositional matrix adjust. Identities = 50/231 (21%), Positives = 92/231 (39%), Gaps = 49/231 (21%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVAR--GQAAVQQLQAEGLSPRFHQLD 63 + A+VTGA GIG IA EL + + + D+ + A ++ G +D Sbjct: 15 KTAVVTGAASGIGKEIALELAKAGA---AVAIADLNQDGANAVADEINKAGGKAIGVAMD 71 Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCN 123 + + +++ D + + +G +++LV+NA + + P + +F + M Sbjct: 72 VTNEEAVNTGIDKVAEAFGSVDILVSNAGIQIVN----PIE-------NYSFADWKKM-- 118 Query: 124 ELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEV 183 ++ AF L+ + + G +V M V Sbjct: 119 ---------------QAIHVDGAFLTTKAALKHMYKDD---RGGVVIYM--------GSV 152 Query: 184 HEREGWP-NSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKT 233 H E P S Y +K G+ L+R+LA+ E K + + + CPG V+T Sbjct: 153 HSHEASPLKSAYVTAKHGLLGLARVLAK---EGAKHN-VRSHVVCPGFVRT 199 >2EBZ-A nrPDB Length = 155 Score = 29.6 bits (65), Expect = 1.6, Method: Compositional matrix adjust. Identities = 16/61 (26%), Positives = 30/61 (49%), Gaps = 3/61 (4%) Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCN 123 + D +R DFLRKE+ N+L A F + +P K E++ + ++ +C+ Sbjct: 23 LQDPVGVRYFSDFLRKEFSEENILFWQACEYF---NHVPAHDKKELSYRAREIFSKFLCS 79 Query: 124 E 124 + Sbjct: 80 K 80 >3CGZ-A nrPDB Length = 157 Score = 29.6 bits (65), Expect = 1.7, Method: Compositional matrix adjust. Identities = 9/22 (40%), Positives = 18/22 (81%) Query: 15 RGIGLAIARELCRQFSGDVVLT 36 +G+GLA+ARE+ Q++G ++ + Sbjct: 113 QGVGLAVAREITEQYAGQIIAS 134 >1ID0-A nrPDB Length = 152 Score = 29.3 bits (64), Expect = 2.1, Method: Compositional matrix adjust. Identities = 10/21 (47%), Positives = 16/21 (76%) Query: 14 NRGIGLAIARELCRQFSGDVV 34 +G+GLA+ARE+ Q+ G +V Sbjct: 107 GQGVGLAVAREITEQYEGKIV 127 >4CQL-A nrPDB Length = 261 Score = 28.9 bits (63), Expect = 2.2, Method: Compositional matrix adjust. Identities = 41/152 (26%), Positives = 66/152 (43%), Gaps = 20/152 (13%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLS---PRFH- 60 S +ALVTGA GIG A++ L + V D A Q V+ L G PR + Sbjct: 11 SALALVTGAGSGIGRAVSVRLAGE-GATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNH 69 Query: 61 ---QLDIDDLQSIRALRDFLRKEYG-GLNVLVNNAAVA-------FKSDDPMPFDIKAEM 109 Q D+ + ++ R L + ++ + +V+V+ A + DD +D + Sbjct: 70 AAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDD---WDKVIAV 126 Query: 110 TLKTNFFATRNMCNELLPIMKPHGRVVNISSL 141 LK F T+ L+ G ++NISS+ Sbjct: 127 NLKGTFLVTQAAAQALVS-NGCRGSIINISSI 157 >3U9L-A nrPDB Length = 324 Score = 28.9 bits (63), Expect = 2.3, Method: Compositional matrix adjust. Identities = 34/145 (23%), Positives = 64/145 (44%), Gaps = 8/145 (5%) Query: 1 MSSCSRVALVTGANRGIGLAIARELC----RQFSGDVVLTARDVARGQAAVQQLQAEGLS 56 M ++ L+TGA+ G G A L R ++ + R+ + +A + + Sbjct: 1 MVMSKKIILITGASSGFGRLTAEALAGAGHRVYASMRDIVGRNASNVEAIAGFARDNDVD 60 Query: 57 PRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAA-VAFKSDDPMPFDIKAEMTLKTNF 115 R +LD+ S+ D + E G ++VL++NA + F + + AE+ N Sbjct: 61 LRTLELDVQSQVSVDRAIDQIIGEDGRIDVLIHNAGHMVFGPAEAFTPEQFAEL-YDINV 119 Query: 116 FATRNMCNELLPIMK--PHGRVVNI 138 +T+ + LP M+ HG ++ I Sbjct: 120 LSTQRVNRAALPHMRRQKHGLLIWI 144 >3E9N-A nrPDB Length = 245 Score = 28.9 bits (63), Expect = 2.5, Method: Compositional matrix adjust. Identities = 12/27 (44%), Positives = 19/27 (70%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCR 27 MS ++A+VTGA G+G+ I ++L R Sbjct: 1 MSLKKKIAVVTGATGGMGIEIVKDLSR 27 >3OML-A nrPDB Length = 613 Score = 28.5 bits (62), Expect = 3.2, Method: Compositional matrix adjust. Identities = 38/151 (25%), Positives = 63/151 (41%), Gaps = 23/151 (15%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQL---------QAEGL 55 RVA+VTGA G+G A + + VV G A Q+ +A G Sbjct: 19 GRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRKAGGE 78 Query: 56 SPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAV----AFKSDDPMPFDIKAEMTL 111 + + ID + I K +G +++LVNNA + + +++ ++ L Sbjct: 79 AVADYNSVIDGAKVIET----AIKAFGRVDILVNNAGILRDRSLVKTSEQDWNLVNDVHL 134 Query: 112 KTNFFATRNMCNELLPIMKP--HGRVVNISS 140 K +F T+ P MK +GR++ SS Sbjct: 135 KGSFKCTQ----AAFPYMKKQNYGRIIMTSS 161 >1CZN-A nrPDB Length = 169 Score = 28.1 bits (61), Expect = 4.1, Method: Compositional matrix adjust. Identities = 10/42 (23%), Positives = 22/42 (52%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAA 46 +++ L G G+ IA + ++F G+ ++ D+A A+ Sbjct: 1 AKIGLFYGTQTGVTQTIAESIQQEFGGESIVDLNDIANADAS 42 >4MDP-A nrPDB Length = 499 Score = 28.1 bits (61), Expect = 4.2, Method: Compositional matrix adjust. Identities = 13/49 (26%), Positives = 22/49 (44%) Query: 68 QSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFF 116 Q R L ++L K YG + V + K ++ MP + E + +F Sbjct: 378 QGFRDLLNWLSKRYGYPKIYVTENGTSLKGENDMPLEQVLEDDFRVKYF 426 >4DRY-A nrPDB Length = 281 Score = 27.7 bits (60), Expect = 5.7, Method: Compositional matrix adjust. Identities = 29/119 (24%), Positives = 49/119 (41%), Gaps = 17/119 (14%) Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKT-NFFATRNM 121 D+ D + AL +R E+ L++LVNNA + P+P + E+T + N N+ Sbjct: 91 DVGDPDQVAALFAAVRAEFARLDLLVNNAG---SNVPPVPLE---EVTFEQWNGIVAANL 144 Query: 122 CNELL------PIMKPH----GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVD 170 L +MK GR++N S+ N + + LT+ +D Sbjct: 145 TGAFLCTQHAFRMMKAQTPRGGRIINNGSISAQTPRPNSAPYTATKHAITGLTKSTALD 203 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2HRB-A nrPDB 362 e-101 3BHI-A nrPDB 334 2e-92 1N5D-A nrPDB 329 1e-90 3O26-A nrPDB 214 3e-56 5L51-A nrPDB 203 5e-53 2UVD-A nrPDB 195 2e-50 4JRO-A nrPDB 192 1e-49 2C07-A nrPDB 189 1e-48 2HQ1-A nrPDB 187 4e-48 3OSU-A nrPDB 187 4e-48 3EZL-A nrPDB 185 1e-47 2PNF-A nrPDB 185 2e-47 3VZS-A nrPDB 185 2e-47 3OEC-A nrPDB 185 2e-47 5YSS-A nrPDB 184 3e-47 3WOH-A nrPDB 184 4e-47 3LYL-A nrPDB 184 4e-47 5LCX-A nrPDB 183 5e-47 5CDY-A nrPDB 182 1e-46 3RSH-A nrPDB 182 1e-46 1Q7C-A nrPDB 181 4e-46 3FTP-A nrPDB 179 1e-45 2CDH-G nrPDB 178 3e-45 4BO1-A nrPDB 177 6e-45 3EMK-A nrPDB 177 6e-45 2Q2Q-A nrPDB 174 4e-44 3U5T-A nrPDB 172 2e-43 3GRP-A nrPDB 171 2e-43 4DMM-A nrPDB 170 6e-43 4RZH-A nrPDB 169 9e-43 4NBV-A nrPDB 169 9e-43 6NRP-A nrPDB 169 1e-42 4M8S-A nrPDB 169 1e-42 4IIV-A nrPDB 169 2e-42 2PH3-A nrPDB 168 2e-42 4K6F-A nrPDB 164 3e-41 4DBZ-A nrPDB 164 4e-41 1GEG-A nrPDB 163 6e-41 5VT6-A nrPDB 163 1e-40 3F9I-A nrPDB 162 2e-40 5ITV-A nrPDB 161 3e-40 3O4R-A nrPDB 161 4e-40 3WTC-A nrPDB 160 5e-40 3V2G-A nrPDB 160 6e-40 2ZAT-A nrPDB 159 8e-40 3V2H-A nrPDB 159 1e-39 1X1T-A nrPDB 157 4e-39 4IIN-A nrPDB 157 4e-39 2AE2-A nrPDB 157 4e-39 4KMS-A nrPDB 157 6e-39 3WYE-A nrPDB 157 6e-39 1AE1-A nrPDB 156 8e-39 3W8F-A nrPDB 155 1e-38 4NBT-A nrPDB 154 3e-38 3R3S-A nrPDB 154 5e-38 4CQM-B nrPDB 153 8e-38 6CI9-A nrPDB 153 8e-38 2NM0-A nrPDB 153 1e-37 3OIC-A nrPDB 152 2e-37 2GDZ-A nrPDB 152 2e-37 1DOH-A nrPDB 151 2e-37 4Z9Y-A nrPDB 151 2e-37 5T5Q-A nrPDB 151 3e-37 5U9P-A nrPDB 150 6e-37 1NFF-A nrPDB 150 7e-37 3AUT-A nrPDB 147 5e-36 5OJG-A nrPDB 146 7e-36 4MOW-A nrPDB 146 1e-35 1UZM-A nrPDB 146 1e-35 3T7C-A nrPDB 142 2e-34 3V8B-A nrPDB 141 3e-34 2CFC-A nrPDB 141 4e-34 2HSD-A nrPDB 141 4e-34 1YXM-A nrPDB 140 6e-34 2B4Q-A nrPDB 139 1e-33 3A28-C nrPDB 136 9e-33 3RWB-A nrPDB 135 2e-32 4HP8-A nrPDB 134 4e-32 4AVY-A nrPDB 131 5e-31 1A27-A nrPDB 129 9e-31 1AHH-A nrPDB 128 2e-30 6CGE-A nrPDB 128 2e-30 4E6P-A nrPDB 127 6e-30 1HXH-A nrPDB 127 7e-30 3RKU-A nrPDB 123 9e-29 2NWQ-A nrPDB 118 3e-27 3KZV-A nrPDB 117 3e-27 4DA9-A nrPDB 115 3e-26 Sequences not found previously or not previously below threshold: 1GEE-A nrPDB 151 3e-37 5OVL-A nrPDB 150 6e-37 5OVJ-A nrPDB 146 7e-36 5B1Y-A nrPDB 142 2e-34 2EW8-A nrPDB 138 2e-33 4TRR-A nrPDB 137 5e-33 3UVE-A nrPDB 137 7e-33 4RZI-B nrPDB 134 3e-32 1K2W-A nrPDB 131 3e-31 5EJ2-A nrPDB 130 8e-31 4CQL-A nrPDB 128 2e-30 1H5Q-A nrPDB 127 3e-30 3UN1-A nrPDB 125 2e-29 3UF0-A nrPDB 125 3e-29 3OML-A nrPDB 122 2e-28 5ILO-A nrPDB 120 8e-28 3ZV3-A nrPDB 120 8e-28 4IS3-A nrPDB 119 1e-27 3GDF-A nrPDB 116 1e-26 1E3W-A nrPDB 116 2e-26 5JY1-A nrPDB 114 3e-26 2O23-A nrPDB 114 4e-26 4RGB-A nrPDB 111 4e-25 3PXX-A nrPDB 110 6e-25 1CYD-A nrPDB 107 4e-24 3D3W-A nrPDB 106 1e-23 5JS6-A nrPDB 105 2e-23 1BDB-A nrPDB 104 6e-23 4EGF-A nrPDB 102 1e-22 4FC7-A nrPDB 101 3e-22 3DWF-A nrPDB 100 6e-22 5IZ4-A nrPDB 100 6e-22 5O3Z-A nrPDB 100 7e-22 2FWM-X nrPDB 99 1e-21 1O5I-A nrPDB 99 2e-21 5PGZ-A nrPDB 98 4e-21 4DRY-A nrPDB 98 5e-21 2X9N-A nrPDB 97 1e-20 3U4C-A nrPDB 96 2e-20 1SNY-A nrPDB 94 5e-20 2QHX-A nrPDB 90 1e-18 3U9L-A nrPDB 90 1e-18 2BFA-A nrPDB 89 2e-18 2BGM-A nrPDB 88 3e-18 2AG5-A nrPDB 87 9e-18 4HBG-A nrPDB 85 3e-17 1P33-A nrPDB 85 3e-17 2YW9-A nrPDB 83 1e-16 3E9N-A nrPDB 83 1e-16 1B15-A nrPDB 83 1e-16 3PPI-A nrPDB 83 2e-16 4GKB-A nrPDB 81 4e-16 4CR6-A nrPDB 81 8e-16 1MG5-A nrPDB 78 5e-15 5WQO-A nrPDB 76 2e-14 2P91-A nrPDB 76 2e-14 5KOI-A nrPDB 74 6e-14 1W73-A nrPDB 73 1e-13 3GRK-A nrPDB 73 1e-13 4Z3K-A nrPDB 71 4e-13 5TF4-A nrPDB 70 1e-12 5TQV-A nrPDB 70 1e-12 1OAA-A nrPDB 68 5e-12 2DKN-A nrPDB 68 5e-12 4HWK-A nrPDB 67 8e-12 3SLK-A nrPDB 66 1e-11 5I9N-A nrPDB 65 3e-11 5YCX-A nrPDB 64 8e-11 4M89-A nrPDB 62 3e-10 3K2E-A nrPDB 61 4e-10 3OIG-A nrPDB 61 6e-10 4NR0-A nrPDB 60 9e-10 1FJH-A nrPDB 58 4e-09 5CFZ-A nrPDB 56 2e-08 2PD3-A nrPDB 56 3e-08 4JQC-A nrPDB 55 3e-08 4ZJU-A nrPDB 55 3e-08 4ALL-A nrPDB 54 5e-08 4J3F-A nrPDB 54 9e-08 3UCF-A nrPDB 52 3e-07 4LIS-A nrPDB 51 7e-07 3RFT-A nrPDB 50 9e-07 3ENK-A nrPDB 49 3e-06 4Q9N-A nrPDB 49 3e-06 2O2S-A nrPDB 47 1e-05 4NK4-A nrPDB 46 2e-05 1Z45-A nrPDB 44 5e-05 3ORF-A nrPDB 44 5e-05 1ENP-A nrPDB 44 5e-05 2NTV-A nrPDB 44 6e-05 4G5H-A nrPDB 44 7e-05 2PK3-A nrPDB 44 8e-05 1GY8-A nrPDB 43 1e-04 1OC2-A nrPDB 43 1e-04 1R66-A nrPDB 43 1e-04 4OYR-A nrPDB 43 2e-04 1I3M-A nrPDB 43 2e-04 2GGS-A nrPDB 42 3e-04 1BXK-A nrPDB 41 7e-04 1UDA-A nrPDB 41 7e-04 5K1S-A nrPDB 39 0.002 4J2O-A nrPDB 39 0.002 4K28-A nrPDB 39 0.002 4J6F-A nrPDB 39 0.002 3F4B-A nrPDB 39 0.003 2GN9-A nrPDB 39 0.003 2PTG-A nrPDB 39 0.003 2NNL-D nrPDB 37 0.007 6GCS-E nrPDB 37 0.008 4R1T-A nrPDB 37 0.008 1KEU-A nrPDB 37 0.009 4R1U-A nrPDB 37 0.010 4EUF-A nrPDB 36 0.019 2O2Y-A nrPDB 36 0.023 1RPN-A nrPDB 36 0.024 3PVZ-A nrPDB 36 0.026 2VN8-A nrPDB 35 0.036 3WMX-A nrPDB 35 0.036 1YB5-A nrPDB 35 0.039 4DGK-A nrPDB 35 0.040 6BWL-A nrPDB 35 0.044 4UUP-A nrPDB 35 0.046 2WEK-A nrPDB 34 0.055 3S8M-A nrPDB 34 0.056 5N2I-A nrPDB 33 0.14 3DMF-A nrPDB 33 0.16 1LU9-A nrPDB 32 0.20 2Q1W-A nrPDB 32 0.20 5F5N-A nrPDB 32 0.25 1IXR-A nrPDB 32 0.25 5NUE-A nrPDB 32 0.31 3ZU2-A nrPDB 32 0.33 2C20-A nrPDB 32 0.38 4EJ0-A nrPDB 31 0.41 2EER-A nrPDB 31 0.45 3QFK-A nrPDB 31 0.50 5XW3-A nrPDB 31 0.51 4AR0-A nrPDB 31 0.56 5U9C-A nrPDB 31 0.57 1DB3-A nrPDB 31 0.57 2Z95-A nrPDB 31 0.59 1OOE-A nrPDB 31 0.88 3R9I-A nrPDB 31 0.90 4KTT-E nrPDB 31 0.91 3T69-A nrPDB 30 0.99 5UZH-A nrPDB 30 1.0 4BKO-A nrPDB 30 1.1 1O89-A nrPDB 30 1.2 4WOK-A nrPDB 30 1.2 2C54-A nrPDB 30 1.3 4BKP-A nrPDB 30 1.4 3F6S-A nrPDB 30 1.4 4E0B-A nrPDB 30 1.5 5A3V-A nrPDB 29 1.9 1JAY-A nrPDB 29 1.9 2X86-A nrPDB 29 2.1 1CJA-A nrPDB 29 2.2 3CT4-A nrPDB 29 2.4 4EJ6-A nrPDB 29 2.6 4P4L-A nrPDB 29 3.0 3JYO-A nrPDB 29 3.1 5GXF-A nrPDB 29 3.1 2DFV-A nrPDB 28 3.5 5M58-A nrPDB 28 3.7 3CJR-A nrPDB 28 4.0 1TLL-A nrPDB 28 4.1 6H5E-B nrPDB 28 4.3 4WJL-A nrPDB 28 4.6 5G1T-A nrPDB 27 6.4 2Z4U-A nrPDB 27 7.3 3L6V-A nrPDB 27 7.7 6MX4-A nrPDB 27 8.7 1VL2-A nrPDB 27 9.5 >2HRB-A nrPDB Length = 274 Score = 362 bits (929), Expect = e-101, Method: Composition-based stats. Identities = 273/273 (100%), Positives = 273/273 (100%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI Sbjct: 2 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 61 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE 124 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE Sbjct: 62 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE 121 Query: 125 LLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVH 184 LLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVH Sbjct: 122 LLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVH 181 Query: 185 EREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTV 244 EREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTV Sbjct: 182 EREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTV 241 Query: 245 EEGAETPVYLALLPPDATEPQGQLVHDKVVQNW 277 EEGAETPVYLALLPPDATEPQGQLVHDKVVQNW Sbjct: 242 EEGAETPVYLALLPPDATEPQGQLVHDKVVQNW 274 >3BHI-A nrPDB Length = 276 Score = 334 bits (857), Expect = 2e-92, Method: Composition-based stats. Identities = 196/271 (72%), Positives = 232/271 (85%) Query: 7 VALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDD 66 VALVTG N+GIGLAI R+LCR FSGDVVLTARDV RGQAAVQQLQAEGLSPRFHQLDIDD Sbjct: 6 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDD 65 Query: 67 LQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELL 126 LQSIRALRDFLRKEYGGL+VLVNNA +AFK DP PF I+AE+T+KTNFF TR++C ELL Sbjct: 66 LQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELL 125 Query: 127 PIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHER 186 P++KP GRVVN+SS+ +RA ++CS +LQ++F SET+TE +LV LM KFVEDTK VH++ Sbjct: 126 PLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQK 185 Query: 187 EGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTVEE 246 EGWP+S YGV+K+GVTVLSRI AR+L E+RK D+IL+NACCPG V+TDM G + ++ EE Sbjct: 186 EGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKATKSPEE 245 Query: 247 GAETPVYLALLPPDATEPQGQLVHDKVVQNW 277 GAETPVYLALLPPDA P GQ V +K V+ W Sbjct: 246 GAETPVYLALLPPDAEGPHGQFVSEKRVEQW 276 >1N5D-A nrPDB Length = 288 Score = 329 bits (842), Expect = 1e-90, Method: Composition-based stats. Identities = 194/276 (70%), Positives = 230/276 (83%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 SS +RVALVTGAN+GIG AI R+LCRQF+GDVVLTARDVARGQAAV+QLQAEGLSPRFHQ Sbjct: 1 SSNTRVALVTGANKGIGFAIVRDLCRQFAGDVVLTARDVARGQAAVKQLQAEGLSPRFHQ 60 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 LDI DLQSIRAL DFLRKEYGGL+VLVNNAA+AF+ D+P PF I+AE+T+KTNF TRN+ Sbjct: 61 LDIIDLQSIRALCDFLRKEYGGLDVLVNNAAIAFQLDNPTPFHIQAELTMKTNFMGTRNV 120 Query: 122 CNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKN 181 C ELLP++KP GRVVN+SS + +RA CS +LQ++F SET+TE +LV LM KFVEDTKN Sbjct: 121 CTELLPLIKPQGRVVNVSSTEGVRALNECSPELQQKFKSETITEEELVGLMNKFVEDTKN 180 Query: 182 EVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSI 241 VH +EGW +S YGV+K+GV+VLSRI AR+L E+R D+IL+NACCPG V+TDM G + Sbjct: 181 GVHRKEGWSDSTYGVTKIGVSVLSRIYARKLREQRAGDKILLNACCPGWVRTDMGGPKAP 240 Query: 242 RTVEEGAETPVYLALLPPDATEPQGQLVHDKVVQNW 277 ++ E GAETPVYLALLP DA P GQ V DK V W Sbjct: 241 KSPEVGAETPVYLALLPSDAEGPHGQFVTDKKVVEW 276 >3O26-A nrPDB Length = 311 Score = 214 bits (545), Expect = 3e-56, Method: Composition-based stats. Identities = 92/299 (30%), Positives = 141/299 (47%), Gaps = 45/299 (15%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQ-AEGLSPRFHQLDI 64 R A+VTG N+GIG I ++L VVLT RDV +G AV++L+ + + FHQLD+ Sbjct: 13 RCAVVTGGNKGIGFEICKQL-SSNGIMVVLTCRDVTKGHEAVEKLKNSNHENVVFHQLDV 71 Query: 65 DDL-QSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKA---------------- 107 D ++ +L DF++ +G L++LVNNA VA S D F Sbjct: 72 TDPIATMSSLADFIKTHFGKLDILVNNAGVAGFSVDADRFKAMISDIGEDSEELVKIYEK 131 Query: 108 --------------EMTLKTNFFATRNMCNELLPIMK--PHGRVVNISSLQCLRAFENCS 151 E LK N+ +++ L+P+++ R+VN+SS + + Sbjct: 132 PEAQELMSETYELAEECLKINYNGVKSVTEVLIPLLQLSDSPRIVNVSSSTGSLKYVSNE 191 Query: 152 EDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWP--NSPYGVSKLGVTVLSRILA 209 L+ + LTE + ++ ++D K + E GWP + Y SK + +R+LA Sbjct: 192 TALEILGDGDALTEERIDMVVNMLLKDFKENLIETNGWPSFGAAYTTSKACLNAYTRVLA 251 Query: 210 RRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTVEEGAETPVYLALLPPDATEPQGQL 268 ++ + VN CPG VKT+M+ T EEGAE V +AL P D P G Sbjct: 252 NKI------PKFQVNCVCPGLVKTEMNYGIGNYTAEEGAEHVVRIALFPDD--GPSGFF 302 >5L51-A nrPDB Length = 324 Score = 203 bits (517), Expect = 5e-53, Method: Composition-based stats. Identities = 87/310 (28%), Positives = 140/310 (45%), Gaps = 52/310 (16%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE-----GLS 56 ++ R A+VTGAN+GIG I ++L + V+L +RD RG A ++L E G Sbjct: 12 AATKRYAVVTGANKGIGFEICKQLASK-GITVILASRDEKRGIEARERLIKELGSEFGDY 70 Query: 57 PRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDD----------------- 99 QLD+ D S+ AL DF++ ++G L++LVNNA + + Sbjct: 71 VVSQQLDVADPASVAALVDFIKTKFGSLDILVNNAGLNGTYMEGDASVLNDYVEAEFKTF 130 Query: 100 -----------------PMPFDIKAEMTLKTNFFATRNMCNELLPIMKPH--GRVVNISS 140 + A+ ++TN++ ++ + L+P+++ R+VN+SS Sbjct: 131 QSGAAKTEPYHPKATGRLVETVEHAKECIETNYYGSKRVTEALIPLLQQSDSPRIVNVSS 190 Query: 141 LQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPN--SPYGVSK 198 F+ E LTE L +++ +F++D + + + WP S Y VSK Sbjct: 191 TLSSLVFQTNEWAKGVFSSEEGLTEEKLEEVLAEFLKDFIDGKQQEKQWPPHFSAYKVSK 250 Query: 199 LGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTVEEGAETPVYLALLP 258 + +RI+A++ +NA CPG KTD+ T E AE PV LALLP Sbjct: 251 AALNAYTRIIAKKYPSF------RINAVCPGYTKTDLSYGHGQFTDAEAAEAPVKLALLP 304 Query: 259 PDATEPQGQL 268 P G Sbjct: 305 Q--GGPSGCF 312 >2UVD-A nrPDB Length = 246 Score = 195 bits (495), Expect = 2e-50, Method: Composition-based stats. Identities = 56/246 (22%), Positives = 94/246 (38%), Gaps = 47/246 (19%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 +VALVTGA+RGIG AIA +L +Q + VV A + + V +++ G + Sbjct: 2 LKGKVALVTGASRGIGRAIAIDLAKQGANVVVNYAGNEQKANEVVDEIKKLGSDAIAVRA 61 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 D+ + + + + +G +++LVNNA V + + + + + TN Sbjct: 62 DVANAEDVTNMVKQTVDVFGQVDILVNNAGVTKDNLLMRMKEEEWDTVINTNLKGVFLCT 121 Query: 123 NELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 + M + HGR+VNI+S+ + Sbjct: 122 KAVSRFMMRQRHGRIVNIASVVGVTGNP-------------------------------- 149 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS 240 + Y +K GV L++ A+ L + I VNA PG + TDM Sbjct: 150 ---------GQANYVAAKAGVIGLTKTSAKELASR----NITVNAIAPGFIATDMTDVLD 196 Query: 241 IRTVEE 246 E Sbjct: 197 ENIKAE 202 >4JRO-A nrPDB Length = 271 Score = 192 bits (487), Expect = 1e-49, Method: Composition-based stats. Identities = 51/255 (20%), Positives = 94/255 (36%), Gaps = 48/255 (18%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M+ +VA+VTG +RGIG IA L ++ + + + + G+ Sbjct: 25 MTLQGKVAVVTGGSRGIGRDIAINLAKEGANIFFNYNGSPEAAEETAKLVAEHGVEVEAM 84 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 + ++ + + A + +G +++LVNNA + + + + + + N T Sbjct: 85 KANVAIAEDVDAFFKQAIERFGRVDILVNNAGITRDNLLMRMKEDEWDDVININLKGTFL 144 Query: 121 MCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + M + G+++N++S+ L Sbjct: 145 CTKAVSRTMMKQRAGKIINMASVVGLIG-------------------------------- 172 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 + Y SK GV L++ AR L + I VNA PG + TDM K Sbjct: 173 ---------NAGQANYVASKAGVIGLTKTTARELAPR----GINVNAVAPGFITTDMTDK 219 Query: 239 DSIRTVEEG-AETPV 252 +T E A+ P+ Sbjct: 220 LDEKTKEAMLAQIPL 234 >2C07-A nrPDB Length = 285 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 56/240 (23%), Positives = 97/240 (40%), Gaps = 48/240 (20%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 ++VALVTGA RGIG IA+ L + S V+ +R + V ++++ G + D+ Sbjct: 44 NKVALVTGAGRGIGREIAKMLAKSVS-HVICISRTQKSCDSVVDEIKSFGYESSGYAGDV 102 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE 124 + I + + + E+ +++LVNNA + + + + E L+TN + + Sbjct: 103 SKKEEISEVINKILTEHKNVDILVNNAGITRDNLFLRMKNDEWEDVLRTNLNSLFYITQP 162 Query: 125 LLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNE 182 + M +GR++NISS+ L + Sbjct: 163 ISKRMINNRYGRIINISSIVGLTGNVGQANY----------------------------- 193 Query: 183 VHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIR 242 SK GV ++ LA+ L + I VNA PG + +DM K S + Sbjct: 194 ------------SSSKAGVIGFTKSLAKELASR----NITVNAIAPGFISSDMTDKISEQ 237 >2HQ1-A nrPDB Length = 247 Score = 187 bits (475), Expect = 4e-48, Method: Composition-based stats. Identities = 53/274 (19%), Positives = 100/274 (36%), Gaps = 48/274 (17%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M + A+VTG++RG+G AIA +L + V+ + A ++ +A G++ Sbjct: 1 MQLKGKTAIVTGSSRGLGKAIAWKLGNMGANIVLNGSPASTSLDATAEEFKAAGINVVVA 60 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 + D+ + + + + +G +++LVNNA + + + + L TN + Sbjct: 61 KGDVKNPEDVENMVKTAMDAFGRIDILVNNAGITRDTLMLKMSEKDWDDVLNTNLKSAYL 120 Query: 121 MCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + IM + G+++NI+S+ + Sbjct: 121 CTKAVSKIMLKQKSGKIINITSIAGIIG-------------------------------- 148 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 + Y SK G+ ++ +A+ K I NA PG +KTDM Sbjct: 149 ---------NAGQANYAASKAGLIGFTKSIAKEFAAK----GIYCNAVAPGIIKTDMTDV 195 Query: 239 DSIRTVE-EGAETPVYLALLPPDATEPQGQLVHD 271 + E P+ P + G L D Sbjct: 196 LPDKVKEMYLNNIPLKRFGTPEEVANVVGFLASD 229 >3OSU-A nrPDB Length = 246 Score = 187 bits (475), Expect = 4e-48, Method: Composition-based stats. Identities = 60/272 (22%), Positives = 106/272 (38%), Gaps = 48/272 (17%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 ++ ALVTGA+RGIG +IA +L + V A + +A V++++A+G+ Q + Sbjct: 3 MTKSALVTGASRGIGRSIALQLAEEGYNVAVNYAGSKEKAEAVVEEIKAKGVDSFAIQAN 62 Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCN 123 + D ++A+ + ++G L+VLVNNA + + + + + + TN N Sbjct: 63 VADADEVKAMIKEVVSQFGSLDVLVNNAGITRDNLLMRMKEQEWDDVIDTNLKGVFNCIQ 122 Query: 124 ELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKN 181 + P M + G ++N+SS+ + + + Sbjct: 123 KATPQMLRQRSGAIINLSSVVGAVGNPGQANYVATK------------------------ 158 Query: 182 EVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSI 241 GV L++ AR L + I VNA PG + +DM S Sbjct: 159 -----------------AGVIGLTKSAARELASR----GITVNAVAPGFIVSDMTDALSD 197 Query: 242 RTVEEG-AETPVYLALLPPDATEPQGQLVHDK 272 E+ + P+ D L DK Sbjct: 198 ELKEQMLTQIPLARFGQDTDIANTVAFLASDK 229 >3EZL-A nrPDB Length = 256 Score = 185 bits (470), Expect = 1e-47, Method: Composition-based stats. Identities = 54/263 (20%), Positives = 95/263 (36%), Gaps = 48/263 (18%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M R+A VTG GIG +I + L + V + R ++ +A G Sbjct: 9 MVMSQRIAYVTGGMGGIGTSICQRLHKDGFRVVAGCGPNSPRRVKWLEDQKALGFDFYAS 68 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 + ++ D S + D ++ E G ++VLVNNA + + + TN + N Sbjct: 69 EGNVGDWDSTKQAFDKVKAEVGEIDVLVNNAGITRDVVFRKMTREDWQAVIDTNLTSLFN 128 Query: 121 MCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + +++ M + GR++NISS+ + Sbjct: 129 VTKQVIDGMVERGWGRIINISSVNGQKG-------------------------------- 156 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 + + Y +K G+ + LA+ + K + VN PG + TDM Sbjct: 157 ---------QFGQTNYSTAKAGIHGFTMSLAQEVATK----GVTVNTVSPGYIGTDMVKA 203 Query: 239 DSIRTVEE-GAETPVYLALLPPD 260 +E+ A PV P + Sbjct: 204 IRPDVLEKIVATIPVRRLGSPDE 226 >2PNF-A nrPDB Length = 248 Score = 185 bits (469), Expect = 2e-47, Method: Composition-based stats. Identities = 57/250 (22%), Positives = 95/250 (38%), Gaps = 49/250 (19%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQ-AEGLSPRFHQ 61 +V+LVTG+ RGIG AIA +L V++T R +A +++ G+ + Sbjct: 5 LQGKVSLVTGSTRGIGRAIAEKLASA-GSTVIITGTSGERAKAVAEEIANKYGVKAHGVE 63 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 +++ +SI + + G+++LVNNA + + E LK N T + Sbjct: 64 MNLLSEESINKAFEEIYNLVDGIDILVNNAGITRDKLFLRMSLLDWEEVLKVNLTGTFLV 123 Query: 122 CNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 L M + GR+VNISS+ Sbjct: 124 TQNSLRKMIKQRWGRIVNISSVVGFTG--------------------------------- 150 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKD 239 Y +K G+ ++ LA+ L + +LVNA PG ++TDM Sbjct: 151 --------NVGQVNYSTTKAGLIGFTKSLAKELAPR----NVLVNAVAPGFIETDMTAVL 198 Query: 240 SIRTVEEGAE 249 S ++ E Sbjct: 199 SEEIKQKYKE 208 >3VZS-A nrPDB Length = 257 Score = 185 bits (469), Expect = 2e-47, Method: Composition-based stats. Identities = 56/261 (21%), Positives = 98/261 (37%), Gaps = 48/261 (18%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 S R+A VTG GIG AI + L + V + R + ++Q +A G + Sbjct: 12 STQRIAYVTGGMGGIGTAICQRLAKDGFRVVAGCGPNSPRREKWLEQQKALGFDFIASEG 71 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 ++ D S + D ++ E G ++VL+NNA + + + TN + N+ Sbjct: 72 NVADWDSTKTAFDKVKSEVGEVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVT 131 Query: 123 NELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 +++ M + GR+VNISS+ + Sbjct: 132 KQVIDGMADRGWGRIVNISSVNGQKG---------------------------------- 157 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS 240 + + Y +K G+ + LA+ + K + VN PG + TDM Sbjct: 158 -------QFGQTNYSTAKAGLHGFTMALAQEVATK----GVTVNTVSPGYIATDMVKAIR 206 Query: 241 IRTVEE-GAETPVYLALLPPD 260 +++ A PV LP + Sbjct: 207 QDVLDKIVATIPVKRLGLPEE 227 >3OEC-A nrPDB Length = 317 Score = 185 bits (469), Expect = 2e-47, Method: Composition-based stats. Identities = 66/287 (22%), Positives = 102/287 (35%), Gaps = 69/287 (24%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVL-----------TARDVARGQAAVQQLQ 51 +VA +TGA RG G A L + + V + + V+ ++ Sbjct: 44 LQGKVAFITGAARGQGRTHAVRLAQDGADIVAIDLCRQQPNLDYAQGSPEELKETVRLVE 103 Query: 52 AEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTL 111 +G Q D+ DL S++A+ D E+G +++LV+N ++ + + D + L Sbjct: 104 EQGRRIIARQADVRDLASLQAVVDEALAEFGHIDILVSNVGISNQGEVVSLTDQQWSDIL 163 Query: 112 KTNFFATRNMCNELLPIM---KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDL 168 +TN + C +LP M G V+ +SS LR Sbjct: 164 QTNLIGAWHACRAVLPSMIERGQGGSVIFVSSTVGLRGAP-------------------- 203 Query: 169 VDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCP 228 S Y SK GV L LA + I VN+ P Sbjct: 204 ---------------------GQSHYAASKHGVQGLMLSLANEVGRH----NIRVNSVNP 238 Query: 229 GPVKTDMDGKDSIR----------TVEEGAETPVYLALLPPDATEPQ 265 G V T+M + + T E+ AE L LLP EP+ Sbjct: 239 GAVNTEMALNEKLLKMFLPHLENPTREDAAELFSQLTLLPIPWVEPE 285 >5YSS-A nrPDB Length = 256 Score = 184 bits (468), Expect = 3e-47, Method: Composition-based stats. Identities = 68/279 (24%), Positives = 110/279 (39%), Gaps = 53/279 (18%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M+ + ALVTG+ GIGL IA+ L + + ++ DV AA + G +P +H Sbjct: 1 MNLTGKTALVTGSTSGIGLGIAQVLAQAGATLILNGFGDV---DAAKDAVAQYGKTPGYH 57 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 D+ D I + + E+GG+++L+NNA + S K + N + + Sbjct: 58 GADLSDEAQIADMMRYAESEFGGVDILINNAGIQHVSPIETFPVDKWNAIIAINLSSVFH 117 Query: 121 MCNELLPIMKP--HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 LP M+ GR++NI+S+ L A + Sbjct: 118 TTRLALPGMRARNWGRIINIASVHGLVASKE----------------------------- 148 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 S Y +K GV L++ +A + I NA CPG V T + + Sbjct: 149 ------------KSAYVAAKHGVVGLTKTIALETAQTE----ITCNALCPGWVLTPLVQQ 192 Query: 239 DSIRTVEEGAE-TPVYLALLPPDATEPQGQLVHDKVVQN 276 + + EGAE ALL +P + V + + N Sbjct: 193 QIDKRIAEGAEPEAARDALLAE--KQPSREFVTPEQLGN 229 >3WOH-A nrPDB Length = 251 Score = 184 bits (467), Expect = 4e-47, Method: Composition-based stats. Identities = 50/264 (18%), Positives = 94/264 (35%), Gaps = 48/264 (18%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 + +VALVTG +RG+G A+A L R + ++ D + + +++ G + R ++ Sbjct: 8 ALSGKVALVTGGSRGLGRAMALRLARDGAAVAIVYVSDDSSAKETQGEIERLGGTARSYR 67 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 D+ D + + + + G +++LVNNA + D + + TN Sbjct: 68 CDVSDAEQVTRCVKAVTADLGPVDILVNNAGIIRDGLAASIKDEDYDAVMNTNLKGAFLF 127 Query: 122 CNE--LLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 I K G ++NISS+ + Sbjct: 128 IKACYFGFIRKRSGSIINISSVSGVFGSA------------------------------- 156 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKD 239 + Y +K G+ L++ +A+ L E+ + NA PG + TDM Sbjct: 157 ----------GQANYASAKAGLIGLTKSIAKELAER----NVRCNAVAPGLIATDMTQDL 202 Query: 240 SIRTVEEGAETPVYLALLPPDATE 263 + P+ P + Sbjct: 203 VDDSKRLDP-VPMRRFGRPDEVAG 225 >3LYL-A nrPDB Length = 247 Score = 184 bits (466), Expect = 4e-47, Method: Composition-based stats. Identities = 62/263 (23%), Positives = 99/263 (37%), Gaps = 49/263 (18%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 MS +VALVTGA+RGIG +A L + VV TA A + ++ +G R Sbjct: 1 MSLNEKVALVTGASRGIGFEVAHALASK-GATVVGTATSQASAEKFENSMKEKGFKARGL 59 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 L+I D++SI+ ++ E +++LVNNA + + + + + + TN + Sbjct: 60 VLNISDIESIQNFFAEIKAENLAIDILVNNAGITRDNLMMRMSEDEWQSVINTNLSSIFR 119 Query: 121 MCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 M E + M K GR+++I S+ Sbjct: 120 MSKECVRGMMKKRWGRIISIGSVVGSAGNP------------------------------ 149 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 + Y +K GV S+ LA + + I VN PG + TDM K Sbjct: 150 -----------GQTNYCAAKAGVIGFSKSLAYEVASR----NITVNVVAPGFIATDMTDK 194 Query: 239 DSIRTVEE-GAETPVYLALLPPD 260 + + P P D Sbjct: 195 LTDEQKSFIATKIPSGQIGEPKD 217 >5LCX-A nrPDB Length = 316 Score = 183 bits (465), Expect = 5e-47, Method: Composition-based stats. Identities = 89/313 (28%), Positives = 138/313 (44%), Gaps = 54/313 (17%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAA----VQQLQAEGLS 56 M+ R ALVTGAN+GIG I R+L + V+LT+R+ RG A +++L Sbjct: 3 MAEVQRYALVTGANKGIGFEICRQLAEK-GIIVILTSRNEKRGLEARQKLLKELNVSENR 61 Query: 57 PRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSD--DPMPFDIKAEMTLK-- 112 FHQLD+ DL S+ A+ F++ ++G L++LVNNA V+ D F+ E K Sbjct: 62 LVFHQLDVTDLASVAAVAVFIKSKFGKLDILVNNAGVSGVEMVGDVSVFNEYIEADFKAL 121 Query: 113 ---------------------------------TNFFATRNMCNELLPIMK--PHGRVVN 137 TN++ + + L+P+++ P R+VN Sbjct: 122 QALEAGAKEEPPFKPKANGEMIEKFEGAKDCVVTNYYGPKRLTQALIPLLQLSPSPRIVN 181 Query: 138 ISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPN--SPYG 195 +SS + LTE + ++++ F++D K E WP + Sbjct: 182 VSSSFGSLLLLWNEWAKGVLGDEDRLTEERVDEVVEVFLKDIKEGKLEESQWPPHFAAER 241 Query: 196 VSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTVEEGAETPVYLA 255 VSK + ++I A++ +NA CPG KTD+ +V E A+ PV LA Sbjct: 242 VSKAALNAYTKIAAKKYPSF------RINAICPGYAKTDITFHAGPLSVAEAAQVPVKLA 295 Query: 256 LLPPDATEPQGQL 268 LLP P G Sbjct: 296 LLPD--GGPSGCF 306 >5CDY-A nrPDB Length = 244 Score = 182 bits (461), Expect = 1e-46, Method: Composition-based stats. Identities = 64/274 (23%), Positives = 100/274 (36%), Gaps = 63/274 (22%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 MS ++ALVTGA+RGIG AIA EL + V+ TA +A L G + Sbjct: 1 MSFEGKIALVTGASRGIGRAIA-ELLVERGACVIGTATSEKGAEAISAYLGENG---KGL 56 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 L++ D SI + +R E+G +++LVNNA + + D + + + TN + Sbjct: 57 MLNVVDPTSIDTVLATIRAEFGEVDILVNNAGITRDNLLMRMKDDEWQDIIDTNLTSVFR 116 Query: 121 MCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + ++ M K GR++ I S+ Sbjct: 117 LSKAVMRAMMKKRFGRIITIGSVVGTMG-------------------------------- 144 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 Y +K GV S+ LAR + + I VN PG ++TDM Sbjct: 145 ---------NAGQVNYAAAKAGVIGFSKSLAREVASR----GITVNVVAPGFIETDMTRT 191 Query: 239 DSIRTVE------------EGAETPVYLALLPPD 260 + + E +A L D Sbjct: 192 LTDDQRAGILAQVPANRLGDAKEIASAVAFLASD 225 >3RSH-A nrPDB Length = 251 Score = 182 bits (461), Expect = 1e-46, Method: Composition-based stats. Identities = 60/261 (22%), Positives = 103/261 (39%), Gaps = 52/261 (19%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M+ +VALVTGA+RGIG AIA L + V+ TA + QA L G + + Sbjct: 8 MNLEGKVALVTGASRGIGKAIAELLA-ERGAKVIGTATSESGAQAISDYL---GDNGKGM 63 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 L++ + +SI A+ + E+GG+++LVNNA + + + + ++TN + Sbjct: 64 ALNVTNPESIEAVLKAITDEFGGVDILVNNAGITRDNLLMRMKEEEWSDIMETNLTSIFR 123 Query: 121 MCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + +L M K GR++N+ S+ Sbjct: 124 LSKAVLRGMMKKRQGRIINVGSVVGTMG-------------------------------- 151 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 + Y +K GV ++ +AR + + + VN PG ++TDM Sbjct: 152 ---------NAGQANYAAAKAGVIGFTKSMAREVASR----GVTVNTVAPGFIETDMTKA 198 Query: 239 DSIRTV-EEGAETPVYLALLP 258 + A+ P P Sbjct: 199 LNDEQRTATLAQVPAGRLGDP 219 >1Q7C-A nrPDB Length = 244 Score = 181 bits (458), Expect = 4e-46, Method: Composition-based stats. Identities = 60/247 (24%), Positives = 98/247 (39%), Gaps = 51/247 (20%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M+ ++ALVTGA+RGIG AIA L + V+ TA QA L A G + Sbjct: 1 MNFEGKIALVTGASRGIGRAIAETLAAR-GAKVIGTATSENGAQAISDYLGANG---KGL 56 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 L++ D SI ++ + +R E+G +++LVNNA + + D + ++TN + Sbjct: 57 MLNVTDPASIESVLEKIRAEFGEVDILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFR 116 Query: 121 MCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + ++ M K HGR++ I S+ Sbjct: 117 LSKAVMRAMMKKRHGRIITIGSVVGTMGNG------------------------------ 146 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 + + +K G+ S+ LAR + + I VN PG ++TDM Sbjct: 147 -----------GQANFAAAKAGLIGFSKSLAREVASR----GITVNVVAPGFIETDMTRA 191 Query: 239 DSIRTVE 245 S Sbjct: 192 LSDDQRA 198 >3FTP-A nrPDB Length = 270 Score = 179 bits (453), Expect = 1e-45, Method: Composition-based stats. Identities = 69/262 (26%), Positives = 102/262 (38%), Gaps = 49/262 (18%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 + +VA+VTGA+RGIG AIA EL R+ V+ TA A + + GL R Sbjct: 25 TLDKQVAIVTGASRGIGRAIALELARR-GAMVIGTATTEAGAEGIGAAFKQAGLEGRGAV 83 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 L+++D ++ AL + KE+G LNVLVNNA + D + + + TN A + Sbjct: 84 LNVNDATAVDALVESTLKEFGALNVLVNNAGITQDQLAMRMKDDEWDAVIDTNLKAVFRL 143 Query: 122 CNELLPIMK--PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 +L M GR+VNI+S+ Sbjct: 144 SRAVLRPMMKARGGRIVNITSVVGSAGNP------------------------------- 172 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKD 239 Y +K GV ++R LAR + + I VN PG + TDM Sbjct: 173 ----------GQVNYAAAKAGVAGMTRALAREIGSR----GITVNCVAPGFIDTDMTKGL 218 Query: 240 -SIRTVEEGAETPVYLALLPPD 260 + + P+ P D Sbjct: 219 PQEQQTALKTQIPLGRLGSPED 240 >2CDH-G nrPDB Length = 244 Score = 178 bits (450), Expect = 3e-45, Method: Composition-based stats. Identities = 57/262 (21%), Positives = 91/262 (34%), Gaps = 48/262 (18%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 S V +VTGA+RGIG AIA L + +V AR + +Q++A G D+ Sbjct: 1 SPVVVVTGASRGIGKAIALSLGKAGCKVLVNYARSAKAAEEVSKQIEAYGGQAITFGGDV 60 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE 124 + A+ +G ++V+VNNA + + + + + N Sbjct: 61 SKEADVEAMMKTAIDAWGTIDVVVNNAGITRDTLLIRMKKSQWDEVIDLNLTGVFLCTQA 120 Query: 125 LLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNE 182 IM K GR++NI+S+ L Sbjct: 121 ATKIMMKKRKGRIINIASVVGLIG------------------------------------ 144 Query: 183 VHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIR 242 + Y +K GV S+ AR + I VN CPG + +DM K Sbjct: 145 -----NIGQANYAAAKAGVIGFSKTAAREGASR----NINVNVVCPGFIASDMTAKLGED 195 Query: 243 TVEEGAET-PVYLALLPPDATE 263 ++ T P+ P + Sbjct: 196 MEKKILGTIPLGRTGQPENVAG 217 >4BO1-A nrPDB Length = 269 Score = 177 bits (448), Expect = 6e-45, Method: Composition-based stats. Identities = 61/247 (24%), Positives = 96/247 (38%), Gaps = 48/247 (19%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 MS +VALVTGA+RGIG AIA EL R V+ TA + + + L+A G+ Sbjct: 23 MSLQGKVALVTGASRGIGQAIALELGR-LGAVVIGTATSASGAEKIAETLKANGVEGAGL 81 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 LD+ +S+ A + +++ G ++VNNA + + D + + TN + Sbjct: 82 VLDVSSDESVAATLEHIQQHLGQPLIVVNNAGITRDNLLVRMKDDEWFDVVNTNLNSLYR 141 Query: 121 MCNELLPIMK--PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + +L M GR++NI S+ Sbjct: 142 LSKAVLRGMTKARWGRIINIGSVVGAMG-------------------------------- 169 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 + Y +K G+ +R LAR + + I VNA PG + TDM + Sbjct: 170 ---------NAGQTNYAAAKAGLEGFTRALAREVGSRA----ITVNAVAPGFIDTDMTRE 216 Query: 239 DSIRTVE 245 E Sbjct: 217 LPEAQRE 223 >3EMK-A nrPDB Length = 246 Score = 177 bits (448), Expect = 6e-45, Method: Composition-based stats. Identities = 58/263 (22%), Positives = 97/263 (36%), Gaps = 52/263 (19%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 R ALVTGA G+G AIAR L Q V L + + +L G Sbjct: 3 FDLTGRKALVTGATGGLGEAIARALHAQ-GAIVGLHGTREEKLKELAAEL---GERIFVF 58 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 ++ D ++++AL +E GG+++LVNNA + D + L N + N Sbjct: 59 PANLSDREAVKALGQKAEEEMGGVDILVNNAGITRDGLFVRMSDEDWDAVLTVNLTSVFN 118 Query: 121 MCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + EL M + +GR++NI+S+ + Sbjct: 119 LTRELTHPMMRRRNGRIINITSIVGVTGNP------------------------------ 148 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 + Y SK G+ S+ LA+ + + + VN PG +++ M GK Sbjct: 149 -----------GQANYCASKAGLIGFSKSLAQEIASR----NVTVNCIAPGFIESAMTGK 193 Query: 239 DSIRT-VEEGAETPVYLALLPPD 260 + + P+ + D Sbjct: 194 LNEKQKDAIMGNIPMKRMGVGAD 216 >2Q2Q-A nrPDB Length = 255 Score = 174 bits (441), Expect = 4e-44, Method: Composition-based stats. Identities = 57/250 (22%), Positives = 93/250 (37%), Gaps = 50/250 (20%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 + + ALVTG+ GIGL IA+ L R + V+ D A A+ ++ G+ H Sbjct: 1 TLKGKTALVTGSTSGIGLGIAQVLARAGANIVLNGFGDPA---PALAEIARHGVKAVHHP 57 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 D+ D+ I AL +E+GG+++LVNNA + + + + N A + Sbjct: 58 ADLSDVAQIEALFALAEREFGGVDILVNNAGIQHVAPVEQFPLESWDKIIALNLSAVFHG 117 Query: 122 CNELLPIMKP--HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 LP M+ GR++NI+S+ L Sbjct: 118 TRLALPGMRARNWGRIINIASVHGLVGST------------------------------- 146 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKD 239 + Y +K GV L++++ + NA CPG V T + K Sbjct: 147 ----------GKAAYVAAKHGVVGLTKVVGLETA----TSNVTCNAICPGWVLTPLVQKQ 192 Query: 240 SIRTVEEGAE 249 G + Sbjct: 193 IDDRAANGGD 202 >3U5T-A nrPDB Length = 267 Score = 172 bits (435), Expect = 2e-43, Method: Composition-based stats. Identities = 63/265 (23%), Positives = 100/265 (37%), Gaps = 47/265 (17%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M ++VA+VTGA+RGIG AIA L V+ A A + +++A G Sbjct: 23 MMETNKVAIVTGASRGIGAAIAARLASDGFTVVINYAGKAAAAEEVAGKIEAAGGKALTA 82 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 Q D+ D ++R L + +GG++VLVNNA + + D + + N T N Sbjct: 83 QADVSDPAAVRRLFATAEEAFGGVDVLVNNAGIMPLTTIAETGDAVFDRVIAVNLKGTFN 142 Query: 121 MCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 E ++ GR++N+S+ Q + Sbjct: 143 TLREAAQRLRVGGRIINMSTSQVGLLHPSYGI---------------------------- 174 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD--MDGK 238 Y +K GV ++ +L++ L + I VNA PGP TD ++GK Sbjct: 175 -------------YAAAKAGVEAMTHVLSKEL----RGRDITVNAVAPGPTATDLFLEGK 217 Query: 239 DSIRTVEEGAETPVYLALLPPDATE 263 P+ P D Sbjct: 218 SDEVRDRFAKLAPLERLGTPQDIAG 242 >3GRP-A nrPDB Length = 266 Score = 171 bits (434), Expect = 2e-43, Method: Composition-based stats. Identities = 59/260 (22%), Positives = 94/260 (36%), Gaps = 52/260 (20%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 R ALVTGA GIG AIAR Q V L + + L G Sbjct: 23 FKLTGRKALVTGATGGIGEAIARCFHAQ-GAIVGLHGTREDKLKEIAADL---GKDVFVF 78 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 ++ D +SI+ L + +E G+++LVNNA + D + L N A Sbjct: 79 SANLSDRKSIKQLAEVAEREMEGIDILVNNAGITRDGLFVRMQDQDWDDVLAVNLTAAST 138 Query: 121 MCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + EL+ M + +GR++NI+S+ + Sbjct: 139 LTRELIHSMMRRRYGRIINITSIVGVVGNP------------------------------ 168 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 + Y +K G+ S+ LA+ + + I VN PG +K+ M K Sbjct: 169 -----------GQTNYCAAKAGLIGFSKALAQEIASR----NITVNCIAPGFIKSAMTDK 213 Query: 239 DSIRTVEE-GAETPVYLALL 257 + + E A P+ + Sbjct: 214 LNEKQKEAIMAMIPMKRMGI 233 >4DMM-A nrPDB Length = 269 Score = 170 bits (430), Expect = 6e-43, Method: Composition-based stats. Identities = 63/283 (22%), Positives = 97/283 (34%), Gaps = 59/283 (20%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 R+ALVTGA+RGIG AIA EL + V A V + A G + Sbjct: 26 LTDRIALVTGASRGIGRAIALELAAAGAKVAVNYASSAGAADEVVAAIAAAGGEAFAVKA 85 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 D+ + AL + + +G L+VLVNNA + + + L N Sbjct: 86 DVSQESEVEALFAAVIERWGRLDVLVNNAGITRDTLLLRMKRDDWQSVLDLNLGGVFLCS 145 Query: 123 NELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 IM + GR++NI+S+ + Sbjct: 146 RAAAKIMLKQRSGRIINIASVVGEMGNPGQANY--------------------------- 178 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS 240 +K GV L++ +A+ L + I VNA PG + TDM + + Sbjct: 179 --------------SAAKAGVIGLTKTVAKELASR----GITVNAVAPGFIATDMTSELA 220 Query: 241 IRTV---------EEGAETPVYLALLPPDATEPQGQLVHDKVV 274 + E AE + L D P + +V+ Sbjct: 221 AEKLLEVIPLGRYGEAAEVAGVVRFLAAD---PAAAYITGQVI 260 >4RZH-A nrPDB Length = 247 Score = 169 bits (429), Expect = 9e-43, Method: Composition-based stats. Identities = 57/274 (20%), Positives = 95/274 (34%), Gaps = 59/274 (21%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 + ++VALVTGA+RGIG A A L VV A+ A V ++ A G Q Sbjct: 3 ALTAQVALVTGASRGIGKATALALAATGMKVVVNYAQSSTAADAVVAEIIANGGEAIAVQ 62 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 ++ + + L ++ ++VLVNNA + + + + N Sbjct: 63 ANVANADEVDQLIKTTLDKFSRIDVLVNNAGITRDTLLLRMKLEDWQAVIDLNLTGVFLC 122 Query: 122 CNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 + +M + GR++NI+S+ + + Sbjct: 123 TKAVSKLMLKQKSGRIINITSVAGMMGNPGQANY-------------------------- 156 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKD 239 +K GV ++ +A+ L + + VNA PG + TDM Sbjct: 157 ---------------SAAKAGVIGFTKTVAKELASR----GVTVNAVAPGFIATDMTENL 197 Query: 240 SIR------------TVEEGAETPVYLALLPPDA 261 + EE A T +LA P A Sbjct: 198 NAEPILQFIPLARYGQPEEVAGTIRFLATDPAAA 231 >4NBV-A nrPDB Length = 246 Score = 169 bits (429), Expect = 9e-43, Method: Composition-based stats. Identities = 60/274 (21%), Positives = 96/274 (35%), Gaps = 60/274 (21%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M RVA++TGA GIG A A+ VVL AR + A +L A G + + Sbjct: 1 MKLQGRVAIITGAAAGIGFATAQRFAED-GAIVVLCDVQEARVREAAARLAATGATVSAY 59 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 ++D+ + A+ + + +++LVNNA + + + + + + N N Sbjct: 60 RVDVTRRDEVDAMVAAVLAAHQRVDILVNNAGITKDARLAKMTEAQFDAVIDVNLKGVFN 119 Query: 121 MCNELLPIMKPHGR--VVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + +M G+ ++N SS+ L + Sbjct: 120 CAQAVAGLMTEQGKGVILNASSVVGLYGNFGQTNYAA----------------------- 156 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD---- 234 SK GV ++ AR L K + VNA CPG V T+ Sbjct: 157 ------------------SKFGVIGFTKTWARELGPK----GVRVNAVCPGFVNTEILQT 194 Query: 235 --------MDGKDSIRTVEEGAETPVYLALLPPD 260 M +R + E AE A L D Sbjct: 195 VPDKVLDGMTSSCWLRRLAEPAEIASIYAFLASD 228 >6NRP-A nrPDB Length = 263 Score = 169 bits (428), Expect = 1e-42, Method: Composition-based stats. Identities = 51/238 (21%), Positives = 94/238 (39%), Gaps = 48/238 (20%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 S +R LVTG++RGIG AIA +L + V A + VQ++QA G + + Sbjct: 20 FQSMTRRILVTGSSRGIGKAIALQLAKAGFDVTVHARSRQAEAEQVVQEIQALGQNSHYL 79 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 D+++ Q+++ + + +++GG +V NA + P D + + T+ N Sbjct: 80 MFDVNERQTVQQILEQDVEQHGGFYGVVLNAGLTHDGAFPALTDQDWDEVISTSLDGFYN 139 Query: 121 MCNELLPIM---KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 + L+ M + GR+V +SS+ + Sbjct: 140 VLKPLIMPMIHLRKGGRIVTLSSVSGIMGNRGQVNY------------------------ 175 Query: 178 DTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 +K G+ ++ LA L ++ +I VN PG ++T+M Sbjct: 176 -----------------SAAKAGLIGATKALALELAKR----KITVNCVAPGLIETEM 212 >4M8S-A nrPDB Length = 248 Score = 169 bits (427), Expect = 1e-42, Method: Composition-based stats. Identities = 53/245 (21%), Positives = 93/245 (37%), Gaps = 50/245 (20%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 ++ALVTGA+RGIG AIA V+ TA + A ++L G R L Sbjct: 6 LSGKIALVTGASRGIGAAIADT-LAAAGAKVIGTATSESGAAAISERLAQWGGEGR--VL 62 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 + + +++ L + K +G L++LVNNA + + + + + ++ N + Sbjct: 63 NSAEPETVENLIADIEKTFGKLDILVNNAGITRDNLLMRMKEEEWDDIMQVNLKSVFRAS 122 Query: 123 NELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 +L M + GR++NI+S+ + Sbjct: 123 KAVLRGMMKQRAGRIINITSVVGVMG---------------------------------- 148 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS 240 + Y +K G+ S+ +AR + + I VN PG + TDM Sbjct: 149 -------NAGQTNYAAAKAGLIGFSKSMAREVGSR----GITVNCVAPGFIDTDMTRALP 197 Query: 241 IRTVE 245 T + Sbjct: 198 EETRQ 202 >4IIV-A nrPDB Length = 267 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 55/273 (20%), Positives = 99/273 (36%), Gaps = 48/273 (17%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 ++ SR LVTGA++GIG AIAR+L V RD A Q + + A G + R Sbjct: 23 NAMSRSVLVTGASKGIGRAIARQLAADGFNIGVHYHRDAAGAQETLNAIVANGGNGRLLS 82 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 D+ + + R + + ++G +V+NA +A + P + + + TN + N+ Sbjct: 83 FDVANREQCREVLEHEIAQHGAWYGVVSNAGIARDAAFPALSNDDWDAVIHTNLDSFYNV 142 Query: 122 CNELLPIM---KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + M + GR++ +SS+ + Sbjct: 143 IQPCIMPMIGARQGGRIITLSSVSGVMGNRGQVNY------------------------- 177 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 +K G+ ++ LA L ++ +I VN PG + T M Sbjct: 178 ----------------SAAKAGIIGATKALAIELAKR----KITVNCIAPGLIDTGMIEM 217 Query: 239 DSIRTVEEGAETPVYLALLPPDATEPQGQLVHD 271 + E + P+ + L+ D Sbjct: 218 EESALKEAMSMIPMKRMGQAEEVAGLASYLMSD 250 >2PH3-A nrPDB Length = 245 Score = 168 bits (426), Expect = 2e-42, Method: Composition-based stats. Identities = 59/271 (21%), Positives = 99/271 (36%), Gaps = 49/271 (18%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH-QLDI 64 R AL+TGA+RGIG AIA L + ++ + + ++ + G ++ Sbjct: 2 RKALITGASRGIGRAIALRLAEDGFALAIHYGQNREKAEEVAEEARRRGSPLVAVLGANL 61 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE 124 + ++ AL + GGL+ LVNNA + + D E L+ N A E Sbjct: 62 LEAEAATALVHQAAEVLGGLDTLVNNAGITRDTLLVRMKDEDWEAVLEANLSAVFRTTRE 121 Query: 125 LLPIMK--PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNE 182 + +M GR+VNI+S+ + Sbjct: 122 AVKLMMKARFGRIVNITSVVGILGNP---------------------------------- 147 Query: 183 VHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIR 242 + Y SK G+ +R +A+ ++ I VNA PG ++T+M + Sbjct: 148 -------GQANYVASKAGLIGFTRAVAKEYAQR----GITVNAVAPGFIETEMTERLPQE 196 Query: 243 TVE-EGAETPVYLALLPPDATEPQGQLVHDK 272 E + P P + E LV +K Sbjct: 197 VKEAYLKQIPAGRFGRPEEVAEAVAFLVSEK 227 >4K6F-A nrPDB Length = 255 Score = 164 bits (416), Expect = 3e-41, Method: Composition-based stats. Identities = 44/235 (18%), Positives = 84/235 (35%), Gaps = 47/235 (20%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 R+A+VTG G+G A++ L VV + + + ++ A G + + Sbjct: 9 MTKRIAVVTGGMGGLGEAVSIRLNDAGHRVVVTYSPNNTGADRWLTEMHAAGREFHAYPV 68 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 D+ D S + + + ++ G +++LVNNA + + + ++TN + NM Sbjct: 69 DVADHDSCQQCIEKIVRDVGPVDILVNNAGITRDMTLRKLDKVNWDAVIRTNLDSVFNMT 128 Query: 123 NELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 + M + GR+VNISS+ + + + Sbjct: 129 KPVCDGMVERGWGRIVNISSVNGSKGSVGQTNYAAAK----------------------- 165 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 G+ ++ LA + K + VN PG + T M Sbjct: 166 ------------------AGMHGFTKSLALEIARK----GVTVNTVSPGYLATKM 198 >4DBZ-A nrPDB Length = 281 Score = 164 bits (415), Expect = 4e-41, Method: Composition-based stats. Identities = 66/276 (23%), Positives = 97/276 (35%), Gaps = 51/276 (18%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 S VALVTGA GIGL IAR L ++ V + AR + +++L+ G+ D+ Sbjct: 26 SEVALVTGATSGIGLEIARRLGKE-GLRVFVCARGEEGLRTTLKELREAGVEADGRTCDV 84 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE 124 + I AL + + YG ++VLVNNA D ++TN + + Sbjct: 85 RSVPEIEALVAAVVERYGPVDVLVNNAGRPGGGATAELADELWLDVVETNLTGVFRVTKQ 144 Query: 125 LLPIM----KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 +L + GR+VNI+S + + + Sbjct: 145 VLKAGGMLERGTGRIVNIASTGGKQGLVHAAPYSA------------------------- 179 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS 240 SK GV ++ L L I VNA CPG V+T M Sbjct: 180 ----------------SKHGVVGFTKALGLELAR----TGITVNAVCPGFVETPMAASVR 219 Query: 241 IRTVEEGAETPVYLALLPPDATEPQGQLVHDKVVQN 276 + E A A P G+ V V Sbjct: 220 -EHYSDIWEVSTEEAFDRITARVPIGRYVQPSEVAE 254 >1GEG-A nrPDB Length = 256 Score = 163 bits (413), Expect = 6e-41, Method: Composition-based stats. Identities = 58/252 (23%), Positives = 85/252 (33%), Gaps = 50/252 (19%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 +VALVTGA +GIG AIA L + V + + A +A ++ G ++D Sbjct: 1 MKKVALVTGAGQGIGKAIALRLVKDGFA-VAIADYNDATAKAVASEINQAGGHAVAVKVD 59 Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCN 123 + D + A + RK GG +V+VNNA VA + + N Sbjct: 60 VSDRDQVFAAVEQARKTLGGFDVIVNNAGVAPSTPIESITPEIVDKVYNINVKGVIWGIQ 119 Query: 124 ELLPIMKP---HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 + K G+++N S + +F Sbjct: 120 AAVEAFKKEGHGGKIINACSQAGHVGNPELAVYSSSKF---------------------- 157 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS 240 V L++ AR L I VN CPG VKT M + Sbjct: 158 -------------------AVRGLTQTAARDLAP----LGITVNGYCPGIVKTPMWAEID 194 Query: 241 IRTVEEGAETPV 252 R V E A P+ Sbjct: 195 -RQVSEAAGKPL 205 >5VT6-A nrPDB Length = 269 Score = 163 bits (411), Expect = 1e-40, Method: Composition-based stats. Identities = 49/262 (18%), Positives = 91/262 (34%), Gaps = 49/262 (18%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 RVA VTG G+G AI+R L V + + + G + + + Sbjct: 23 QAKRVAFVTGGMGGLGAAISRRLHDAGMAVAVSHSERNDHVSTWLMHERDAGRDFKAYAV 82 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 D+ D +S + + ++G ++VL+NNA + + + ++T+ A N+ Sbjct: 83 DVADFESCERCAEKVLADFGKVDVLINNAGITRDATFMKMTKGDWDAVMRTDLDAMFNVT 142 Query: 123 NELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 + + M + GR+VNI S+ R Sbjct: 143 KQFIAGMVERRFGRIVNIGSVNGSRG---------------------------------- 168 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDG--K 238 + + Y +K G+ ++ LA ++ I VN PG + T M Sbjct: 169 -------AFGQANYASAKAGIHGFTKTLALETAKR----GITVNTVSPGYLATAMVEAVP 217 Query: 239 DSIRTVEEGAETPVYLALLPPD 260 + + + PV P + Sbjct: 218 QDVLEAKILPQIPVGRLGRPDE 239 >3F9I-A nrPDB Length = 249 Score = 162 bits (409), Expect = 2e-40, Method: Composition-based stats. Identities = 50/263 (19%), Positives = 96/263 (36%), Gaps = 56/263 (21%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 + + +L+TGA+ GIG AIA L + V+++ + + ++ L+ Sbjct: 10 IDLTGKTSLITGASSGIGSAIA-RLLHKLGSKVIISGSNEEKLKSLGNALKDN---YTIE 65 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 ++ + + L L++LV NA + + D + + N A Sbjct: 66 VCNLANKEECSNLISKTSN----LDILVCNAGITSDTLAIRMKDQDFDKVIDINLKANFI 121 Query: 121 MCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + E + M K +GR++NISS+ + Sbjct: 122 LNREAIKKMIQKRYGRIINISSIVGIAGNP------------------------------ 151 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 + Y SK G+ +++ L+ + + I VNA PG +K+DM K Sbjct: 152 -----------GQANYCASKAGLIGMTKSLSYEVATR----GITVNAVAPGFIKSDMTDK 196 Query: 239 DSIRTVEE-GAETPVYLALLPPD 260 + + E + P+ +P D Sbjct: 197 LNEKQREAIVQKIPLGTYGIPED 219 >5ITV-A nrPDB Length = 255 Score = 161 bits (407), Expect = 3e-40, Method: Composition-based stats. Identities = 52/247 (21%), Positives = 86/247 (34%), Gaps = 50/247 (20%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M+ + L+TG GIG A + Q +VV+ D A+G+A V+ + F Sbjct: 3 MNLTDKTVLITGGASGIGYAAVQAFLGQQ-ANVVVADIDEAQGEAMVR--KENNDRLHFV 59 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 Q DI D + + + +GGL+VL+NNA + + L+ N Sbjct: 60 QTDITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELSDWNKVLQVNLTGMFL 119 Query: 121 MCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 M L M G ++N S+ L A+ + + Sbjct: 120 MSKHALKHMLAAGKGNIINTCSVGGLVAWPDIPAYNASK--------------------- 158 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 GV L++ +A + +I VN CPG + T ++ K Sbjct: 159 --------------------GGVLQLTKSMAVDYAKH----QIRVNCVCPGIIDTPLNEK 194 Query: 239 DSIRTVE 245 + E Sbjct: 195 SFLENNE 201 >3O4R-A nrPDB Length = 261 Score = 161 bits (406), Expect = 4e-40, Method: Composition-based stats. Identities = 66/267 (24%), Positives = 94/267 (35%), Gaps = 52/267 (19%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 ++VALVT + GIG AIAR L + VV+++R AV LQ EGLS Sbjct: 13 LANKVALVTASTDGIGFAIARRLAQD-GAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVC 71 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVA-FKSDDPMPFDIKAEMTLKTNFFATRNM 121 + + L K +GG+++LV+NAAV F + + TL N A M Sbjct: 72 HVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALM 131 Query: 122 CNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 ++P M + G VV +SS+ S Sbjct: 132 TKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPY-------------------------- 165 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD---MD 236 VSK + L++ LA L + I VN PG +KT M Sbjct: 166 ---------------NVSKTALLGLTKTLAIELAPR----NIRVNCLAPGLIKTSFSRML 206 Query: 237 GKDSIRTVEEGAETPVYLALLPPDATE 263 D + + P D Sbjct: 207 WMDKEKEESMKETLRIRRLGEPEDCAG 233 >3WTC-A nrPDB Length = 262 Score = 160 bits (405), Expect = 5e-40, Method: Composition-based stats. Identities = 54/248 (21%), Positives = 81/248 (32%), Gaps = 49/248 (19%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 MS ++A VTGA +GIG AIA L + DV+L ++++A G Sbjct: 4 MSLSGKIAAVTGAAQGIGKAIALRLAKD-GADVILLDVKQDTLAETAKEVEALGRRAVAL 62 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 DI + R+ K GGL+++VNNA + + E N Sbjct: 63 TADISNRDQFRSTLADAAKTLGGLDIMVNNAGICQVKPILDIEPAEIEKIFSINVQGVLW 122 Query: 121 MCNELLPIMKPHG---RVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 + K G +++N S+ + Sbjct: 123 GMQAAATLFKEKGTKGKIINACSIAGHEGYPLLG-------------------------- 156 Query: 178 DTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDG 237 Y +K V L++ A+ L I VN+ CPG V TDM Sbjct: 157 ---------------AYSATKFAVRALTQSAAKELAS----SGITVNSYCPGIVGTDMWV 197 Query: 238 KDSIRTVE 245 R E Sbjct: 198 TIDKRMAE 205 >3V2G-A nrPDB Length = 271 Score = 160 bits (404), Expect = 6e-40, Method: Composition-based stats. Identities = 59/278 (21%), Positives = 93/278 (33%), Gaps = 53/278 (19%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 +S + A VTG +RGIG AIA+ L + + + R QA V +++ G Sbjct: 27 ISLAGKTAFVTGGSRGIGAAIAKRLALEGAAVALTYVNAAERAQAVVSEIEQAGGRAVAI 86 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 + D D ++I + GGL++LVN+A + + + + NF A Sbjct: 87 RADNRDAEAIEQAIRETVEALGGLDILVNSAGIWHSAPLEETTVADFDEVMAVNFRAPFV 146 Query: 121 MCNELLPIMKPHGRVVNISS-LQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 + GR++ I S L L + S + Sbjct: 147 AIRSASRHLGDGGRIITIGSNLAELVPWPGISLYSASK---------------------- 184 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKD 239 + L++ LAR L + I VN PG TDM+ D Sbjct: 185 -------------------AALAGLTKGLARDLGPR----GITVNIVHPGSTDTDMNPAD 221 Query: 240 SIRTVEE-------GAETPVYLALLPPDATEPQGQLVH 270 + P +A L PQG+ V Sbjct: 222 GDHAEAQRERIATGSYGEPQDIAGLVAWLAGPQGKFVT 259 >2ZAT-A nrPDB Length = 260 Score = 159 bits (403), Expect = 8e-40, Method: Composition-based stats. Identities = 61/237 (25%), Positives = 90/237 (37%), Gaps = 49/237 (20%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 ++VALVT + GIGLAIAR L + VV+++R V LQ EGLS Sbjct: 12 LENKVALVTASTDGIGLAIARRLAQD-GAHVVVSSRKQENVDRTVATLQGEGLSVTGTVC 70 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVA-FKSDDPMPFDIKAEMTLKTNFFATRNM 121 + + L +GG+++LV+NAAV F + + + L N AT M Sbjct: 71 HVGKAEDRERLVAMAVNLHGGVDILVSNAAVNPFFGNIIDATEEVWDKILHVNVKATVLM 130 Query: 122 CNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 ++P M + G V+ +SS+ F N Sbjct: 131 TKAVVPEMEKRGGGSVLIVSSVGAYHPFPNLGPY-------------------------- 164 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMD 236 VSK + L++ LA L + I VN PG +KT+ Sbjct: 165 ---------------NVSKTALLGLTKNLAVELAPR----NIRVNCLAPGLIKTNFS 202 >3V2H-A nrPDB Length = 281 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 51/245 (20%), Positives = 88/245 (35%), Gaps = 48/245 (19%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEG-LSPRFH 60 S ++ A++TG+ GIGLAIAR L + + V+ + ++ + H Sbjct: 22 SMMTKTAVITGSTSGIGLAIARTLAKAGANIVLNGFGAPDEIRTVTDEVAGLSSGTVLHH 81 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 D+ I + + +GG ++LVNNA V F + + + N ++ + Sbjct: 82 PADMTKPSEIADMMAMVADRFGGADILVNNAGVQFVEKIEDFPVEQWDRIIAVNLSSSFH 141 Query: 121 MCNELLPIMKP--HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 +P MK GR++NI+S L A S Sbjct: 142 TIRGAIPPMKKKGWGRIINIASAHGLVASPFKSAY------------------------- 176 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 +K G+ L++ +A + E + VN+ CPG V T + K Sbjct: 177 ----------------VAAKHGIMGLTKTVALEVAE----SGVTVNSICPGYVLTPLVEK 216 Query: 239 DSIRT 243 Sbjct: 217 QIPDQ 221 >1X1T-A nrPDB Length = 260 Score = 157 bits (397), Expect = 4e-39, Method: Composition-based stats. Identities = 64/275 (23%), Positives = 99/275 (36%), Gaps = 48/275 (17%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE-GLSPRFHQ 61 +VA+VTG+ GIGL IA L Q + V+ D A + L A+ G+ + Sbjct: 2 LKGKVAVVTGSTSGIGLGIATALAAQGADIVLNGFGDAAEIEKVRAGLAAQHGVKVLYDG 61 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 D+ +++R L D ++ G +++LVNNA + + K + L N A + Sbjct: 62 ADLSKGEAVRGLVDNAVRQMGRIDILVNNAGIQHTALIEDFPTEKWDAILALNLSAVFHG 121 Query: 122 CNELLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 LP MK GR++NI+S L A N S Sbjct: 122 TAAALPHMKKQGFGRIINIASAHGLVASANKSAY-------------------------- 155 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKD 239 +K GV +++ A I NA CPG V+T + K Sbjct: 156 ---------------VAAKHGVVGFTKVTALETA----GQGITANAICPGWVRTPLVEKQ 196 Query: 240 SIRTVEEGAETPVYLALLPPDATEPQGQLVHDKVV 274 E+ A +P Q V + + Sbjct: 197 ISALAEKNGVDQETAARELLSEKQPSLQFVTPEQL 231 >4IIN-A nrPDB Length = 271 Score = 157 bits (397), Expect = 4e-39, Method: Composition-based stats. Identities = 48/248 (19%), Positives = 78/248 (31%), Gaps = 47/248 (18%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M + L+TGA++GIG IA+ L + + A +L+ +G Sbjct: 25 MQFTGKNVLITGASKGIGAEIAKTLASMGLKVWINYRSNAEVADALKNELEEKGYKAAVI 84 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 + D + + GGL+ LVNNA V + N + Sbjct: 85 KFDAASESDFIEAIQTIVQSDGGLSYLVNNAGVVRDKLAIKMKTEDFHHVIDNNLTSAFI 144 Query: 121 MCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 C E L +M G VVN++S+ R Sbjct: 145 GCREALKVMSKSRFGSVVNVASIIGERG-------------------------------- 172 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 + Y SK G+ +S+ A + I N+ PG ++TDM+ Sbjct: 173 ---------NMGQTNYSASKGGMIAMSKSFAYEGALR----NIRFNSVTPGFIETDMNAN 219 Query: 239 DSIRTVEE 246 + Sbjct: 220 LKDELKAD 227 >2AE2-A nrPDB Length = 260 Score = 157 bits (397), Expect = 4e-39, Method: Composition-based stats. Identities = 60/280 (21%), Positives = 94/280 (33%), Gaps = 66/280 (23%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 + ALVTG +RGIG I EL V +R+ + Q +++G Sbjct: 6 NLEGCTALVTGGSRGIGYGIVEELAS-LGASVYTCSRNQKELNDCLTQWRSKGFKVEASV 64 Query: 62 LDIDDLQSIRALRDFLRKEY-GGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 D+ + L + + + G LN+LVNNA + + + + NF A + Sbjct: 65 CDLSSRSERQELMNTVANHFHGKLNILVNNAGIVIYKEAKDYTVEDYSLIMSINFEAAYH 124 Query: 121 MCNELLPIMK--PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + P +K G VV ISS+ A Sbjct: 125 LSVLAHPFLKASERGNVVFISSVSGALAVPY----------------------------- 155 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKT---DM 235 + YG +K + L+R LA + D I VN PG + T +M Sbjct: 156 ------------EAVYGATKGAMDQLTRCLAFEWAK----DNIRVNGVGPGVIATSLVEM 199 Query: 236 DGKD--------------SIRTVEEGAETPVYLALLPPDA 261 +D ++R + E E +A L A Sbjct: 200 TIQDPEQKENLNKLIDRCALRRMGEPKELAAMVAFLCFPA 239 >4KMS-A nrPDB Length = 249 Score = 157 bits (396), Expect = 6e-39, Method: Composition-based stats. Identities = 51/237 (21%), Positives = 86/237 (36%), Gaps = 53/237 (22%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 S +A+VTG RGIG A A EL + V + AA + + G+ + + Sbjct: 9 MSEIAIVTGGTRGIGKATALELKNKGLTVVANFFSNY---DAAKEMEEKYGIKTKCW--N 63 Query: 64 IDDLQSIRALRDFLRKEYGG-LNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 + D + R + +E+ +++LVNNA + + N + NM Sbjct: 64 VADFEECRQAVKEIEEEFKKPVSILVNNAGITKDKMLHRMSHQDWNDVINVNLNSCFNMS 123 Query: 123 NELLPIMKP--HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 + ++ M+ +GR+VNISS+ Sbjct: 124 SSVMEQMRNQDYGRIVNISSINA------------------------------------- 146 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDG 237 + + Y +K G+ ++ LAR K I VN PG + T+M G Sbjct: 147 ----QAGQVGQTNYSAAKAGIIGFTKALARETASK----NITVNCIAPGYIATEMVG 195 >3WYE-A nrPDB Length = 256 Score = 157 bits (396), Expect = 6e-39, Method: Composition-based stats. Identities = 52/237 (21%), Positives = 80/237 (33%), Gaps = 43/237 (18%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 +VALVTGA +GIG AIA L + V + + A +A ++ G ++D Sbjct: 1 MKKVALVTGAGQGIGKAIALRLVKDGFA-VAIADYNDATAKAVASEINQAGGHAVAVKVD 59 Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCN 123 + D + A + RK GG +V+VNNA +A + + N F+ Sbjct: 60 VSDRDQVFAAVEQARKTLGGFDVIVNNAGIAQIKPLLEVTEEDLKQIYSVNVFSVFFGIQ 119 Query: 124 ELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEV 183 + K G + + + Sbjct: 120 AAVEAFKKEGH--------------------------------------GGKIINAASIA 141 Query: 184 HEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS 240 + S Y +K V L++ AR L I VN CPG V T M + Sbjct: 142 AIQGFPILSAYSTTKFAVRGLTQTAARDLAP----LGITVNGYCPGIVGTGMWEQID 194 >1AE1-A nrPDB Length = 273 Score = 156 bits (395), Expect = 8e-39, Method: Composition-based stats. Identities = 54/269 (20%), Positives = 93/269 (34%), Gaps = 56/269 (20%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 S ALVTG ++GIG AI EL V +R+ ++ + +GL+ Sbjct: 18 SLKGTTALVTGGSKGIGYAIVEELAG-LGARVYTCSRNEKELDECLEIWREKGLNVEGSV 76 Query: 62 LDIDDLQSIRALRDFLRKEY-GGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 D+ L + + G LN+LVNNA V + + + + TNF A + Sbjct: 77 CDLLSRTERDKLMQTVAHVFDGKLNILVNNAGVVIHKEAKDFTEKDYNIIMGTNFEAAYH 136 Query: 121 MCNELLPIMK--PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + P++K +G V+ +SS+ A + S + Sbjct: 137 LSQIAYPLLKASQNGNVIFLSSIAGFSALPSVSLYSASK--------------------- 175 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 + +++ LA + D I VN+ PG + T + Sbjct: 176 --------------------GAINQMTKSLACEWAK----DNIRVNSVAPGVILTPLVET 211 Query: 239 DSIRTVEEGAE-------TPVYLALLPPD 260 + + E TP+ A P + Sbjct: 212 AIKKNPHQKEEIDNFIVKTPMGRAGKPQE 240 >3W8F-A nrPDB Length = 260 Score = 155 bits (392), Expect = 1e-38, Method: Composition-based stats. Identities = 61/275 (22%), Positives = 98/275 (35%), Gaps = 48/275 (17%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE-GLSPRFHQ 61 + A+VTG+ GIGLA+A EL + + V+ + L+++ G+ + Sbjct: 2 LKGKKAVVTGSTSGIGLAMATELAKAGADVVINGFGQPEDIERERSTLESKFGVKAYYLN 61 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 D+ D Q+ R + GGL++LVNNA + + K + N A + Sbjct: 62 ADLSDAQATRDFIAKAAEALGGLDILVNNAGIQHTAPIEEFPVDKWNAIIALNLSAVFHG 121 Query: 122 CNELLPIMKP--HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 LPIM+ GR++NI+S L A N S Sbjct: 122 TAAALPIMQKQGWGRIINIASAHGLVASVNKSAY-------------------------- 155 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKD 239 +K GV L+++ A I NA CPG V+T + K Sbjct: 156 ---------------VAAKHGVVGLTKVTALE----NAGKGITCNAICPGWVRTPLVEKQ 196 Query: 240 SIRTVEEGAETPVYLALLPPDATEPQGQLVHDKVV 274 ++ A +P Q V + + Sbjct: 197 IEAISQQKGIDIEAAARELLAEKQPSLQFVTPEQL 231 >4NBT-A nrPDB Length = 240 Score = 154 bits (390), Expect = 3e-38, Method: Composition-based stats. Identities = 42/235 (17%), Positives = 81/235 (34%), Gaps = 55/235 (23%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 +VA++TG +G+G AIA + + + D L + L Sbjct: 4 LEGKVAVITGGAKGLGQAIALAYAEEGAKVIAGDLGD----------LTYSHPNVEGMYL 53 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 ++ D+ + + +YG +++LVNNA + + + + + + N N+ Sbjct: 54 NVTDVTGVEKFYQSVIDKYGKIDILVNNAGITKDAMTRKMTEAQWDAVIDVNLKGVFNLT 113 Query: 123 NELLPIMK--PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 + P M+ +G ++NISS+ + + Sbjct: 114 RLVGPQMQTNGYGSIINISSVVGVFGNIGQANY--------------------------- 146 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 +K GV L+ A+ K + VNA PG + TD+ Sbjct: 147 --------------AATKAGVIGLTMTWAKEFA--LKGANVRVNAIAPGYIMTDI 185 >3R3S-A nrPDB Length = 294 Score = 154 bits (388), Expect = 5e-38, Method: Composition-based stats. Identities = 56/261 (21%), Positives = 92/261 (35%), Gaps = 52/261 (19%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQA--AVQQLQAEGLSPRFHQLD 63 R ALVTG + GIG A A R+ DV + A ++ G D Sbjct: 50 RKALVTGGDSGIGRAAAIAYARE-GADVAINYLPAEEEDAQQVKALIEECGRKAVLLPGD 108 Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAV-AFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 + D R+L R+ GGL++L A + + + T N FA + Sbjct: 109 LSDESFARSLVHKAREALGGLDILALVAGKQTAIPEIKDLTSEQFQQTFAVNVFALFWIT 168 Query: 123 NELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNE 182 E +P++ ++ SS+Q + + + Sbjct: 169 QEAIPLLPKGASIITTSSIQAYQPSPHLLD------------------------------ 198 Query: 183 VHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMD---GKD 239 Y +K + SR LA+++ EK I VN PGP+ T + G+ Sbjct: 199 -----------YAATKAAILNYSRGLAKQVAEK----GIRVNIVAPGPIWTALQISGGQT 243 Query: 240 SIRTVEEGAETPVYLALLPPD 260 + + G +TP+ A P + Sbjct: 244 QDKIPQFGQQTPMKRAGQPAE 264 >4CQM-B nrPDB Length = 244 Score = 153 bits (386), Expect = 8e-38, Method: Composition-based stats. Identities = 53/235 (22%), Positives = 81/235 (34%), Gaps = 51/235 (21%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 +V V G +RGIG A+A+ + R+ + + AR++ +AA L G D Sbjct: 8 MDKVCAVFGGSRGIGRAVAQLMARK-GYRLAVIARNLEGAKAAAGDL---GGDHLAFSCD 63 Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCN 123 + ++ + L K G +N LVN A + L TN + C Sbjct: 64 VAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCK 123 Query: 124 ELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKN 181 + M + G +VN+ S+ L+ S Sbjct: 124 AAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVY---------------------------- 155 Query: 182 EVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMD 236 SK G+ SR LA+ + K +I VN PG V TDM Sbjct: 156 -------------SASKGGLVGFSRALAKEVARK----KIRVNVVAPGFVHTDMT 193 >6CI9-A nrPDB Length = 259 Score = 153 bits (386), Expect = 8e-38, Method: Composition-based stats. Identities = 56/235 (23%), Positives = 77/235 (32%), Gaps = 47/235 (20%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 S R A+VTG ++GIG IA DVV+T R+ V L + Sbjct: 6 SLEGRSAIVTGGSKGIGRGIAETFANA-GVDVVITGRNQDDLDRTVADLSGTRGKVTAVR 64 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 D+ D + R +GGL+++ NA + E L NF T + Sbjct: 65 ADVTDPEDARRTVAETVSRHGGLDIVCANAGIFPSGRLEDLTPDDIEQVLGVNFKGTVYI 124 Query: 122 CNELLPIMK--PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 L + HGRVV SS+ Sbjct: 125 VQAALQALTASGHGRVVVTSSITG------------------------------------ 148 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD 234 + GW S YG SK R A L K +I +NA PG + T+ Sbjct: 149 --PITGYPGW--SHYGASKAAQLGFLRTAAMELAPK----KITINAVLPGNIMTE 195 >2NM0-A nrPDB Length = 253 Score = 153 bits (385), Expect = 1e-37, Method: Composition-based stats. Identities = 62/257 (24%), Positives = 84/257 (32%), Gaps = 62/257 (24%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 S SR LVTG NRGIGLAIAR V +T R + + Sbjct: 18 SHMSRSVLVTGGNRGIGLAIARAFA-DAGDKVAITYRSGEPPE-----------GFLAVK 65 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 DI D + + + + +G + VL+ NA V + ++TN T + Sbjct: 66 CDITDTEQVEQAYKEIEETHGPVEVLIANAGVTKDQLLMRMSEEDFTSVVETNLTGTFRV 125 Query: 122 CNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 M GRVV ISS+ L Sbjct: 126 VKRANRAMLRAKKGRVVLISSVVGLLGSA------------------------------- 154 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKD 239 + Y SK G+ +R LAR L + I N PG V TDM Sbjct: 155 ----------GQANYAASKAGLVGFARSLARELGSR----NITFNVVAPGFVDTDMT--- 197 Query: 240 SIRTVEEGAETPVYLAL 256 + T E+ A + L Sbjct: 198 KVLTDEQRANIVSQVPL 214 >3OIC-A nrPDB Length = 258 Score = 152 bits (383), Expect = 2e-37, Method: Composition-based stats. Identities = 55/233 (23%), Positives = 89/233 (38%), Gaps = 47/233 (20%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 ++ ALVTG++RG+G A A L V+ AR ++++ G+ + + Sbjct: 3 QNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALETAEEIEKLGVKVLVVKAN 62 Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCN 123 + I+ + + + +G L+V VNNAA + + T+ N A Sbjct: 63 VGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELEETHWDWTMNINAKALLFCAQ 122 Query: 124 ELLPIMKP--HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKN 181 E +M+ G +V+ISSL +R EN Sbjct: 123 EAAKLMEKNGGGHIVSISSLGSIRYLENY------------------------------- 151 Query: 182 EVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD 234 + GVSK + L+R LA L K +I+VNA G + TD Sbjct: 152 ----------TTVGVSKAALEALTRYLAVELSPK----QIIVNAVSGGAIDTD 190 >2GDZ-A nrPDB Length = 267 Score = 152 bits (383), Expect = 2e-37, Method: Composition-based stats. Identities = 59/242 (24%), Positives = 82/242 (33%), Gaps = 61/242 (25%) Query: 1 MSSC--SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQA--EGLS 56 M+ +VALVTGA +GIG A A L + V L ++ G L E Sbjct: 1 MAHMVNGKVALVTGAAQGIGRAFAEALLLK-GAKVALVDWNLEAGVQCKAALHEQFEPQK 59 Query: 57 PRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFF 116 F Q D+ D Q +R + +G L++LVNNA V + E TL+ N Sbjct: 60 TLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNN--------EKNWEKTLQINLV 111 Query: 117 ATRNMCNELLPIMKP-----HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDL 171 + + L M G ++N+SSL L Sbjct: 112 SVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQ---------------------- 149 Query: 172 MKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPV 231 Y SK G+ +R A L + +NA CPG V Sbjct: 150 -------------------QPVYCASKHGIVGFTRSAA--LAANLMNSGVRLNAICPGFV 188 Query: 232 KT 233 T Sbjct: 189 NT 190 >1DOH-A nrPDB Length = 283 Score = 151 bits (382), Expect = 2e-37, Method: Composition-based stats. Identities = 53/273 (19%), Positives = 95/273 (34%), Gaps = 58/273 (21%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 S +VALVTGA RGIG +A EL R+ +V A + V ++ G + Sbjct: 26 SLEGKVALVTGAGRGIGREMAMELGRRGCKVIVNYANSTESAEEVVAAIKKNGSDAACVK 85 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 ++ ++ I + + K +G L+++ +N+ V + + N + Sbjct: 86 ANVGVVEDIVRMFEEAVKIFGKLDIVCSNSGVVSFGHVKDVTPEEFDRVFTINTRGQFFV 145 Query: 122 CNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKN 181 E ++ GR++ + S+ Sbjct: 146 AREAYKHLEIGGRLILMGSITG-------------------------------------- 167 Query: 182 EVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM------ 235 + ++ Y SK + +R +A + +K +I VN PG +KTDM Sbjct: 168 --QAKAVPKHAVYSGSKGAIETFARCMAIDMADK----KITVNVVAPGGIKTDMYHAVCR 221 Query: 236 --DGKDSIRTVEEGAE------TPVYLALLPPD 260 + EE E +P+ LP D Sbjct: 222 EYIPNGENLSNEEVDEYAAVQWSPLRRVGLPID 254 >4Z9Y-A nrPDB Length = 253 Score = 151 bits (382), Expect = 2e-37, Method: Composition-based stats. Identities = 50/271 (18%), Positives = 93/271 (34%), Gaps = 54/271 (19%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 +VAL+TG + G+G +A L + V ++ + ++++ A G Sbjct: 6 FDLQGKVALITGCDTGLGQGMAIGLAQAGCDIV---GVNIVEPKDTIEKVTALGRRFLSL 62 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 D+ ++ L + E+G +++LVNNA + + D + + + N + Sbjct: 63 TADMSNVSGHAELVEKAVAEFGHVDILVNNAGIIRREDAIEFSEKNWDDVMNLNIKSVFF 122 Query: 121 MCNELLPIM---KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 M + G+++NI+S+ + Sbjct: 123 MSQTVARQFIKQGKGGKIINIASMLSFQG------------------------------- 151 Query: 178 DTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDG 237 G Y SK V ++R++A + I VNA PG + T+ Sbjct: 152 ----------GIRVPSYTASKSAVMGVTRLMANEWAKH----GINVNAIAPGYMATNNTQ 197 Query: 238 K---DSIRTVEEGAETPVYLALLPPDATEPQ 265 + D R+ E P LP D P Sbjct: 198 QLRADEERSKEILDRIPAGRWGLPQDLMGPS 228 >1GEE-A nrPDB Length = 261 Score = 151 bits (382), Expect = 3e-37, Method: Composition-based stats. Identities = 43/241 (17%), Positives = 82/241 (34%), Gaps = 50/241 (20%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 +V ++TG++ G+G ++A + + VV + +++++ G + Sbjct: 5 LEGKVVVITGSSTGLGKSMAIRFATEKAKVVVNYRSKEDEANSVLEEIKKVGGEAIAVKG 64 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 D+ + L KE+G L+V++NNA + + TN Sbjct: 65 DVTVESDVINLVQSAIKEFGKLDVMINNAGLENPVSSHEMSLSDWNKVIDTNLTGAFLGS 124 Query: 123 NELLPIMKPH---GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 E + + G V+N+SS+ Sbjct: 125 REAIKYFVENDIKGTVINMSSVH------------------------------------- 147 Query: 180 KNEVHEREGWP-NSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 E+ WP Y SK G+ +++ LA K I VN PG + T ++ + Sbjct: 148 -----EKIPWPLFVHYAASKGGMKLMTETLALEYAPK----GIRVNNIGPGAINTPINAE 198 Query: 239 D 239 Sbjct: 199 K 199 >5T5Q-A nrPDB Length = 247 Score = 151 bits (381), Expect = 3e-37, Method: Composition-based stats. Identities = 57/283 (20%), Positives = 89/283 (31%), Gaps = 56/283 (19%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 +R ++TGAN GIG AIA EL ++VLT D A L Sbjct: 5 FEFENRTLVLTGANGGIGRAIA-ELFHASGANLVLTDLDREGLDAFAASL-GSPERIATI 62 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 + D + +GG++ LV +A + D T+ N Sbjct: 63 KADASSADDAEKTVALAMERFGGIDFLVPSAGIYQAKPFAEMSDADWHRTISINLDGVFY 122 Query: 121 MCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 +C LP +K +V ++SL R + Sbjct: 123 LCKRALPALKEDSSIVTLASLAAYRGAYVNAHY--------------------------- 155 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK-D 239 G +K + ++R L+R L K VN PG ++T M + Sbjct: 156 --------------GATKGAMVSMTRALSRELAPKT-----RVNGVSPGIIETPMTSELL 196 Query: 240 SIRTVEEGAETPVYLALLPPDAT-------EPQGQLVHDKVVQ 275 R E +TP+ P + P V + +Q Sbjct: 197 KTRMDETMTQTPLKRLGKPSEIASVIAFLCSPAASFVTGETIQ 239 >5U9P-A nrPDB Length = 265 Score = 150 bits (379), Expect = 6e-37, Method: Composition-based stats. Identities = 47/236 (19%), Positives = 87/236 (36%), Gaps = 48/236 (20%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 R AL+TG+ RGIGL +AR L + +V+ R+ + ++ + EG + Sbjct: 18 LDGRRALITGSGRGIGLTLARGLAEAGAA-IVINDRNEEKAATLARRFRDEGFAADHAVF 76 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 D+ + +RA D G +++LVNNA + ++ ++ N N+ Sbjct: 77 DVAEHAQVRAAIDEFEARVGAIDILVNNAGIQRRAPLDAFEPDDWHALMRVNLDGVFNVA 136 Query: 123 NELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 + M + HG+++NI S+Q A Sbjct: 137 QAVARHMIARGHGKIINICSVQSELARPTI------------------------------ 166 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMD 236 +PY +K V +L++ + I N PG +T+++ Sbjct: 167 -----------APYAATKGAVRMLTKGMCADWARY----GIQANGLAPGYFETELN 207 >5OVL-A nrPDB Length = 300 Score = 150 bits (379), Expect = 6e-37, Method: Composition-based stats. Identities = 51/246 (20%), Positives = 80/246 (32%), Gaps = 59/246 (23%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 + SR LVTG NRGIGLAIAR L V +T R Q Sbjct: 65 AFVSRSVLVTGGNRGIGLAIARRLAAD-GHKVAVTHRGSGAPDDL-----------FGVQ 112 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 D+ D ++ + + G + VLV NA ++ + + + E + TN Sbjct: 113 CDVTDSAAVDRAFKEVEEHQGPVEVLVANAGISKDAFLMRMTEERFEEVINTNLTGAFRC 172 Query: 122 CNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 M K GR++ I S+ + N Sbjct: 173 AQRASRTMQRKRFGRIIFIGSVSGMWGIGN------------------------------ 202 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKD 239 + Y +K G+ ++R ++R L + + N PG + T+M Sbjct: 203 -----------QANYAAAKAGLIGMARSISRELAKA----GVTANVVAPGYIDTEMTRAL 247 Query: 240 SIRTVE 245 R Sbjct: 248 DERIQA 253 >1NFF-A nrPDB Length = 260 Score = 150 bits (378), Expect = 7e-37, Method: Composition-based stats. Identities = 54/267 (20%), Positives = 84/267 (31%), Gaps = 58/267 (21%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 +VALV+G RG+G + R + + + V D + R+ L Sbjct: 5 LTGKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEG----KAMAAELADAARYVHL 60 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 D+ +A D +GGL+VLVNNA + + + L N Sbjct: 61 DVTQPAQWKAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGI 120 Query: 123 NELLPIMKPHGR--VVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 ++ MK GR ++NISS++ L C +F Sbjct: 121 RAVVKPMKEAGRGSIINISSIEGLAGTVACHGYTATKFAVR------------------- 161 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDG--- 237 L++ A L I VN+ PG VKT M Sbjct: 162 ----------------------GLTKSTALELGP----SGIRVNSIHPGLVKTPMTDWVP 195 Query: 238 ----KDSIRTVEEGAETPVYLALLPPD 260 + ++ E E + L D Sbjct: 196 EDIFQTALGRAAEPVEVSNLVVYLASD 222 >3AUT-A nrPDB Length = 269 Score = 147 bits (370), Expect = 5e-36, Method: Composition-based stats. Identities = 40/237 (16%), Positives = 79/237 (33%), Gaps = 48/237 (20%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 +V ++TG + G+G A+A ++ + V+ + A ++++ G Q D+ Sbjct: 16 KVVVITGGSTGLGRAMAVRFGQEEAKVVINYYNNEEEALDAKKEVEEAGGQAIIVQGDVT 75 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNEL 125 + + L KE+G L+V++NNA V + TN E Sbjct: 76 KEEDVVNLVQTAIKEFGTLDVMINNAGVENPVPSHELSLDNWNKVIDTNLTGAFLGSREA 135 Query: 126 LPIMKPH---GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNE 182 + + G V+N+SS+ + + + Sbjct: 136 IKYFVENDIKGNVINMSSVHEMIPWPLFVHYAASK------------------------- 170 Query: 183 VHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKD 239 G+ +++ LA K I VN PG + T ++ + Sbjct: 171 ----------------GGMKLMTETLALEYAPK----GIRVNNIGPGAMNTPINAEK 207 >5OJG-A nrPDB Length = 260 Score = 146 bits (369), Expect = 7e-36, Method: Composition-based stats. Identities = 62/279 (22%), Positives = 103/279 (36%), Gaps = 56/279 (20%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGL-SPRFHQ 61 +VA+VT A +GIGLAIA L + VV+ +R+ A++ L+ +GL Sbjct: 8 FEGKVAIVTAATKGIGLAIAERLLDE-GASVVIGSRNQKNVDEAIEYLKNKGLTKVAGIA 66 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAF-KSDDPMPFDIKAEMTLKTNFFATRN 120 I + L DF +++G +N+LVNN + D + + N A Sbjct: 67 GHIASTDDQKKLVDFTLQKFGKINILVNNHGINPAFGHILEVSDQVWDKLFEVNVKAGFQ 126 Query: 121 MCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 M + P + + G ++ +S ++ + Sbjct: 127 MTKLVHPHIAKEGGGAIIFNASYSAYKSPPGIA--------------------------- 159 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMD-- 236 YGV+K + L+R LA L + D I VN PG +KT M Sbjct: 160 --------------AYGVTKTTLVGLTRALAMGLAK----DNIRVNGIAPGVIKTKMSQV 201 Query: 237 ----GKDSIRTVEEGAETPVYLALLPPDATEPQGQLVHD 271 G+D+ + + + E + +P D L D Sbjct: 202 LWDGGEDAEKELTDIQEIALGRLGVPDDCAGTVAYLASD 240 >5OVJ-A nrPDB Length = 256 Score = 146 bits (369), Expect = 7e-36, Method: Composition-based stats. Identities = 51/248 (20%), Positives = 80/248 (32%), Gaps = 59/248 (23%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 + SR LVTG NRGIGLAIAR L V +T R Q Sbjct: 21 AFVSRSVLVTGGNRGIGLAIARRLAAD-GHKVAVTHRGSGAPDDL-----------FGVQ 68 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 D+ D ++ + + G + VLV NA ++ + + + E + TN Sbjct: 69 CDVTDSAAVDRAFKEVEEHQGPVEVLVANAGISKDAFLMRMTEERFEEVINTNLTGAFRC 128 Query: 122 CNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 M K GR++ I S+ + N Sbjct: 129 AQRASRTMQRKRFGRIIFIGSVSGMWGIGN------------------------------ 158 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKD 239 + Y +K G+ ++R ++R L + + N PG + T+M Sbjct: 159 -----------QANYAAAKAGLIGMARSISRELAKA----GVTANVVAPGYIDTEMTRAL 203 Query: 240 SIRTVEEG 247 R Sbjct: 204 DERIQAGA 211 >4MOW-A nrPDB Length = 256 Score = 146 bits (368), Expect = 1e-35, Method: Composition-based stats. Identities = 54/262 (20%), Positives = 87/262 (33%), Gaps = 49/262 (18%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 +VA+VTGA++GIG AIA+ L + + VV A A A V + G Sbjct: 12 LAGKVAIVTGASKGIGAAIAKALADEGAAVVVNYASSKAGADAVVSAITEAGGRAVAVGG 71 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 D+ + + D + YG L+VLVNN+ V + + TN F Sbjct: 72 DVSKAADAQRIVDTAIETYGRLDVLVNNSGVYEFAPIEAITEEHYRRQFDTNVFGVLLTT 131 Query: 123 NELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNE 182 + + ++NISS+ + Sbjct: 132 QAAVKHLGEGASIINISSVVTSITPPASAVY----------------------------- 162 Query: 183 VHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS-- 240 +K V ++ +LA L + +I VNA PG + T+ Sbjct: 163 ------------SGTKGAVDAITGVLALELGPR----KIRVNAINPGMIVTEGTHSAGII 206 Query: 241 --IRTVEEGAETPVYLALLPPD 260 + +TP+ P D Sbjct: 207 GSDLEAQVLGQTPLGRLGEPND 228 >1UZM-A nrPDB Length = 247 Score = 146 bits (367), Expect = 1e-35, Method: Composition-based stats. Identities = 55/264 (20%), Positives = 88/264 (33%), Gaps = 60/264 (22%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 SR LVTG NRGIGLAIA+ L V +T R + ++ Sbjct: 13 FVSRSVLVTGGNRGIGLAIAQRLAAD-GHKVAVTHRGSGAPK-----------GLFGVEV 60 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 D+ D ++ + + G + VLV+NA ++ + + K E + N + Sbjct: 61 DVTDSDAVDRAFTAVEEHQGPVEVLVSNAGLSADAFLMRMTEEKFEKVINANLTGAFRVA 120 Query: 123 NELLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 M+ + GR++ I S+ L N Sbjct: 121 QRASRSMQRNKFGRMIFIGSVSGLWGIGN------------------------------- 149 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS 240 + Y SK GV ++R +AR L + + N PG + TDM Sbjct: 150 ----------QANYAASKAGVIGMARSIARELSKA----NVTANVVAPGYIDTDMTRALD 195 Query: 241 IRTVEEGAE-TPVYLALLPPDATE 263 R + + P P + Sbjct: 196 ERIQQGALQFIPAKRVGTPAEVAG 219 >5B1Y-A nrPDB Length = 270 Score = 142 bits (357), Expect = 2e-34, Method: Composition-based stats. Identities = 57/262 (21%), Positives = 89/262 (33%), Gaps = 50/262 (19%) Query: 8 ALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEG-LSPRFHQLDIDD 66 ALVTG +RGIG A R+ V+ + ++ + G ++D+ D Sbjct: 26 ALVTGGSRGIGRATVLRFAREGWSVVIAYKSRADLAEKTAEEARRLGSPEAYTVRVDVGD 85 Query: 67 LQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELL 126 S+ + + + LNVLVN A V + E TL+ N + LL Sbjct: 86 PDSVTEMSSRVGELIPHLNVLVNAAGVLQLGGIEETSISEWEETLRVNLTGVYLVTKLLL 145 Query: 127 PIMK--PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVH 184 P+++ +VN++S+ Sbjct: 146 PLLRKAKWASIVNVASIAGETGNVVAG--------------------------------- 172 Query: 185 EREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMD---GKDSI 241 Y SK GV L++ LA +L I VNA P V+TDM Sbjct: 173 -------VAYSASKAGVIGLTKRLAVQLA----GYGIRVNAVAPSFVETDMTRSFLDTPE 221 Query: 242 RTVEEGAETPVYLALLPPDATE 263 + + P+ + L P D E Sbjct: 222 KRERIASLHPLKIILKPEDVAE 243 >3T7C-A nrPDB Length = 299 Score = 142 bits (357), Expect = 2e-34, Method: Composition-based stats. Identities = 61/285 (21%), Positives = 96/285 (33%), Gaps = 70/285 (24%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTA-----------RDVARGQAAVQQLQAE 53 +VA +TGA RG G + A L R+ + + + V+Q++A Sbjct: 28 GKVAFITGAARGQGRSHAITLAREGADIIAIDVCKQLDGVKLPMSTPDDLAETVRQVEAL 87 Query: 54 GLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIK-AEMTLK 112 G Q+D+ D +++A D + G L++++ NAA+A + D K + Sbjct: 88 GRRIIASQVDVRDFDAMQAAVDDGVTQLGRLDIVLANAALASEGTRLNRMDPKTWRDMID 147 Query: 113 TNFFATRNMCNELLPIM---KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLV 169 N +P + K G +V SS+ LR EN + Sbjct: 148 VNLNGAWITARVAIPHIMAGKRGGSIVFTSSIGGLRGAENIGNYI--------------- 192 Query: 170 DLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPG 229 SK G+ L R +A L + I VN CP Sbjct: 193 --------------------------ASKHGLHGLMRTMALELGPR----NIRVNIVCPS 222 Query: 230 PVKTDMDGKD----------SIRTVEEGAETPVYLALLPPDATEP 264 V T M + TVE+ + +LP EP Sbjct: 223 SVATPMLLNEPTYRMFRPDLENPTVEDFQVASRQMHVLPIPYVEP 267 >3V8B-A nrPDB Length = 283 Score = 141 bits (355), Expect = 3e-34, Method: Composition-based stats. Identities = 60/272 (22%), Positives = 95/272 (34%), Gaps = 61/272 (22%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M+ S VAL+TGA GIG A A L L R + ++ G Sbjct: 24 MNQPSPVALITGAGSGIGRATALALAADGVTVGAL-GRTRTEVEEVADEIVGAGGQAIAL 82 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAV---AFKSDDPMPFDIKAEMTLKTNFFA 117 + D+ D +R L ++G L+++V NA + DD PF+ + T+ N Sbjct: 83 EADVSDELQMRNAVRDLVLKFGHLDIVVANAGINGVWAPIDDLKPFE--WDETIAVNLRG 140 Query: 118 TRNMCNELLPIMKP--HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKF 175 T + +P +K G +V +SS+ R F + Sbjct: 141 TFLTLHLTVPYLKQRGGGAIVVVSSINGTRTFTTPGATAYTATKAAQ------------- 187 Query: 176 VEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 + + LA L + I VNA CPG ++T++ Sbjct: 188 --------------------------VAIVQQLALELGKHH----IRVNAVCPGAIETNI 217 Query: 236 DGKDSIRTVEEGAETPVYLALLPPDATEPQGQ 267 +R EE A +P + P+GQ Sbjct: 218 SDNTKLRHEEETA--------IPVEW--PKGQ 239 >2CFC-A nrPDB Length = 250 Score = 141 bits (354), Expect = 4e-34, Method: Composition-based stats. Identities = 53/238 (22%), Positives = 82/238 (34%), Gaps = 50/238 (21%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 SRVA+VTGA+ G GLAIA + L + A A + D Sbjct: 1 MSRVAIVTGASSGNGLAIATRFLARGDRVAALDLSAETLEETARTHWHAYADKVLRVRAD 60 Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDI---KAEMTLKTNFFATRN 120 + D + A +++G ++VLVNNA + S+ + + + + N Sbjct: 61 VADEGDVNAAIAATMEQFGAIDVLVNNAGITGNSEAGVLHTTPVEQFDKVMAVNVRGIFL 120 Query: 121 MCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 C +LP M + G +VNI+S+ L AF S + Sbjct: 121 GCRAVLPHMLLQGAGVIVNIASVASLVAFPGRSAYTTSK--------------------- 159 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMD 236 V L++ +A I NA CPG ++T M Sbjct: 160 --------------------GAVLQLTKSVAVDYA----GSGIRCNAVCPGMIETPMT 193 >2HSD-A nrPDB Length = 253 Score = 141 bits (354), Expect = 4e-34, Method: Composition-based stats. Identities = 64/272 (23%), Positives = 98/272 (36%), Gaps = 52/272 (19%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 + ++TG RG+G AR+ VVL G A ++L G + R+ L Sbjct: 3 LSGKTVIITGGARGLGAEAARQ-AVAAGARVVLADVLDEEGAATAREL---GDAARYQHL 58 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 D+ + + + + R+E+G ++ LVNNA ++ + ++ N Sbjct: 59 DVTIEEDWQRVVAYAREEFGSVDGLVNNAGISTGMFLETESVERFRKVVEINLTGVFIGM 118 Query: 123 NELLPIMK--PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 ++P MK G +VNISS L Sbjct: 119 KTVIPAMKDAGGGSIVNISSAAGLMGLALT------------------------------ 148 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS 240 S YG SK GV LS++ A L DRI VN+ PG T M + Sbjct: 149 -----------SSYGASKWGVRGLSKLAAVELG----TDRIRVNSVHPGMTYTPMTAETG 193 Query: 241 IRTVE-EGAETPVYLALLPPDATEPQGQLVHD 271 IR E TP+ P + +L+ D Sbjct: 194 IRQGEGNYPNTPMGRVGEPGEIAGAVVKLLSD 225 >1YXM-A nrPDB Length = 303 Score = 140 bits (353), Expect = 6e-34, Method: Composition-based stats. Identities = 57/237 (24%), Positives = 86/237 (36%), Gaps = 56/237 (23%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGL-----SP 57 +VA+VTG GIG AI +EL + +VV+ +R + R ++A +LQA Sbjct: 16 LQGQVAIVTGGATGIGKAIVKELL-ELGSNVVIASRKLERLKSAADELQANLPPTKQARV 74 Query: 58 RFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFA 117 Q +I + + + L +G +N LVNN F S L+TN Sbjct: 75 IPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTG 134 Query: 118 TRNMCNELL-PIMKPH-GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKF 175 T MC + MK H G +VNI Sbjct: 135 TFYMCKAVYSSWMKEHGGSIVNI------------------------------------- 157 Query: 176 VEDTKNEVHEREGWPNS-PYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPV 231 V + G+P + G ++ GV L++ LA I +N PG + Sbjct: 158 ------IVPTKAGFPLAVHSGAARAGVYNLTKSLALEWA----CSGIRINCVAPGVI 204 >2B4Q-A nrPDB Length = 276 Score = 139 bits (350), Expect = 1e-33, Method: Composition-based stats. Identities = 62/269 (23%), Positives = 96/269 (35%), Gaps = 55/269 (20%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 S R+ALVTG +RGIG IA+ L + V + ARD +L A G + Sbjct: 25 FSLAGRIALVTGGSRGIGQMIAQGLL-EAGARVFICARDAEACADTATRLSAYG-DCQAI 82 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 D+ R L L + L++LVNNA ++ + E ++ N + + Sbjct: 83 PADLSSEAGARRLAQALGELSARLDILVNNAGTSWGAALESYPVSGWEKVMQLNVTSVFS 142 Query: 121 MCNELLPIMKPH------GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKK 174 +LLP+++ RV+NI S+ + A + Sbjct: 143 CIQQLLPLLRRSASAENPARVINIGSVAGISAMGEQAY---------------------- 180 Query: 175 FVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD 234 YG SK + LSR+LA+ L + I VN PG + Sbjct: 181 ------------------AYGPSKAALHQLSRMLAKEL----VGEHINVNVIAPGRFPSR 218 Query: 235 MD---GKDSIRTVEEGAETPVYLALLPPD 260 M D + A P+ P + Sbjct: 219 MTRHIANDPQALEADSASIPMGRWGRPEE 247 >2EW8-A nrPDB Length = 249 Score = 138 bits (348), Expect = 2e-33, Method: Composition-based stats. Identities = 44/230 (19%), Positives = 77/230 (33%), Gaps = 50/230 (21%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 ++A++TG GIG AIA + + + +AA ++ G + D+ Sbjct: 8 KLAVITGGANGIGRAIAERFAVEGADIAIADLVPAPEAEAA---IRNLGRRVLTVKCDVS 64 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNEL 125 + A + +G ++LVNNA + + + T + N + M Sbjct: 65 QPGDVEAFGKQVISTFGRCDILVNNAGIYPLIPFDELTFEQWKKTFEINVDSGFLMAKAF 124 Query: 126 LPIMKP--HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEV 183 +P MK GR++N++S E + + Sbjct: 125 VPGMKRNGWGRIINLTSTTYWLKIEAYTHYI----------------------------- 155 Query: 184 HEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKT 233 +K +R LA L + D I VNA P V+T Sbjct: 156 ------------STKAANIGFTRALASDLGK----DGITVNAIAPSLVRT 189 >4TRR-A nrPDB Length = 269 Score = 137 bits (345), Expect = 5e-33, Method: Composition-based stats. Identities = 42/248 (16%), Positives = 82/248 (33%), Gaps = 49/248 (19%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 + + A+VTGA GIG IA EL + + + + A ++ G Sbjct: 11 NLNGKTAVVTGAASGIGKEIALELAKAGAAV-AIADLNQDGANAVADEINKAGGKAIGVA 69 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 +D+ + +++ D + + +G +++LV+NA + + + + Sbjct: 70 MDVTNEEAVNTGIDKVAEAFGSVDILVSNAGIQIVNPIENYSFADWKKMQAIHVDGAFLT 129 Query: 122 CNELLPIM---KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 L M G V+ + S+ A Sbjct: 130 TKAALKHMYKDDRGGVVIYMGSVHSHEASPL----------------------------- 160 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 S Y +K G+ L+R+LA+ + + + CPG V+T + K Sbjct: 161 ------------KSAYVTAKHGLLGLARVLAKEGAKH----NVRSHVVCPGFVRTPLVDK 204 Query: 239 DSIRTVEE 246 +E Sbjct: 205 QIPEQAKE 212 >3UVE-A nrPDB Length = 286 Score = 137 bits (344), Expect = 7e-33, Method: Composition-based stats. Identities = 51/289 (17%), Positives = 87/289 (30%), Gaps = 74/289 (25%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLT---------------ARDVARGQAAVQQ 49 +VA VTGA RG G + A L ++ + + + A Sbjct: 11 GKVAFVTGAARGQGRSHAVRLAQEGADIIAVDICKPIRAGVVDTAIPASTPEDLAETADL 70 Query: 50 LQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPF-DIKAE 108 ++ ++D+ D +++A D ++ G L+++V NA + D + Sbjct: 71 VKGHNRRIVTAEVDVRDYDALKAAVDSGVEQLGRLDIIVANAGIGNGGDTLDKTSEEDWT 130 Query: 109 MTLKTNFFATRNMCNELLPIMKPHGR---VVNISSLQCLRAFENCSEDLQERFHSETLTE 165 + N +P M GR ++ SS+ L+A+ + Sbjct: 131 EMIDINLAGVWKTVKAGVPHMIAGGRGGSIILTSSVGGLKAYPHTG-------------- 176 Query: 166 GDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNA 225 Y +K GV L R L + I VN+ Sbjct: 177 ---------------------------HYVAAKHGVVGLMRAFGVELGQHM----IRVNS 205 Query: 226 CCPGPVKTDMDGKDSIRT----------VEEGAETPVYLALLPPDATEP 264 P VKT M + ++ A LP EP Sbjct: 206 VHPTHVKTPMLHNEGTFKMFRPDLENPGPDDMAPICQMFHTLPIPWVEP 254 >3A28-C nrPDB Length = 258 Score = 136 bits (343), Expect = 9e-33, Method: Composition-based stats. Identities = 47/238 (19%), Positives = 78/238 (32%), Gaps = 43/238 (18%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGD-VVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 S+VA+VTG +GIG I+ +L V + + ++ ++A F L Sbjct: 1 MSKVAMVTGGAQGIGRGISEKLAADGFDIAVADLPQQEEQAAETIKLIEAADQKAVFVGL 60 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 D+ D + + D ++ GG +VLVNNA +A + + N F+ Sbjct: 61 DVTDKANFDSAIDEAAEKLGGFDVLVNNAGIAQIKPLLEVTEEDLKQIYSVNVFSVFFGI 120 Query: 123 NELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNE 182 G +K + + + Sbjct: 121 QAASRKFDELG--------------------------------------VKGKIINAASI 142 Query: 183 VHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS 240 + S Y +K V L++ A+ L K VNA PG V T M + Sbjct: 143 AAIQGFPILSAYSTTKFAVRGLTQAAAQELAPKGH----TVNAYAPGIVGTGMWEQID 196 >3RWB-A nrPDB Length = 247 Score = 135 bits (339), Expect = 2e-32, Method: Composition-based stats. Identities = 53/235 (22%), Positives = 83/235 (35%), Gaps = 52/235 (22%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 + ALVTGA +GIG AIA L V+++ + +AA + G R Sbjct: 4 LAGKTALVTGAAQGIGKAIAARLAAD-GATVIVSDINAEGAKAAAASI---GKKARAIAA 59 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 DI D S++AL ++ GG+++LVNNA++ + N T + Sbjct: 60 DISDPGSVKALFAEIQALTGGIDILVNNASIVPFVAWDDVDLDHWRKIIDVNLTGTFIVT 119 Query: 123 NELLPIMK---PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 M+ GRV++I+S N + Sbjct: 120 RAGTDQMRAAGKAGRVISIASNTFFAGTPNMAAY-------------------------- 153 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD 234 +K GV +R LA L + I NA PG +++D Sbjct: 154 ---------------VAAKGGVIGFTRALATELGKY----NITANAVTPGLIESD 189 >4RZI-B nrPDB Length = 240 Score = 134 bits (338), Expect = 3e-32, Method: Composition-based stats. Identities = 50/263 (19%), Positives = 80/263 (30%), Gaps = 59/263 (22%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 + +V +VTG NRGIG AI + L ++ V T G Sbjct: 4 LGLEDKVIVVTGGNRGIGAAIVK-LLQEMGAKVAFTDLATDGGNT----------EALGV 52 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 ++ DL+S+ A + + G + +V NA + + P + L N Sbjct: 53 VANVTDLESMTAAAAEITDKLGPVYGVVANAGITKDNFFPKLTPADWDAVLNVNLKGVAY 112 Query: 121 MCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + M + G +V ISS+ R Sbjct: 113 SIKPFIEGMYERKAGSIVAISSISGERG-------------------------------- 140 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 + Y +K GV + + LAR + NA PG + T+M Sbjct: 141 ---------NVGQTNYSATKAGVIGMMKSLAREGARY----GVRANAVAPGFIDTEMTLA 187 Query: 239 DSIRTVEE-GAETPVYLALLPPD 260 E+ E P P + Sbjct: 188 IREDIREKITKEIPFRRFGKPEE 210 >4HP8-A nrPDB Length = 247 Score = 134 bits (337), Expect = 4e-32, Method: Composition-based stats. Identities = 54/236 (22%), Positives = 82/236 (34%), Gaps = 56/236 (23%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 S R ALVTGAN G+G AIA L +VV AR + + +G + Sbjct: 5 FSLEGRKALVTGANTGLGQAIAVGLAAA-GAEVVCAARRAP--DETLDIIAKDGGNASAL 61 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 +D D + + G ++LVNNA + ++D ++ + + N A Sbjct: 62 LIDFADPLAAKDSFTDA-----GFDILVNNAGIIRRADSVEFSELDWDEVMDVNLKALFF 116 Query: 121 MCNELLPIM---KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 + G+VVNI+SL + Sbjct: 117 TTQAFAKELLAKGRSGKVVNIASLLSFQG------------------------------- 145 Query: 178 DTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKT 233 G Y +K GV L+++LA K I VNA PG ++T Sbjct: 146 ----------GIRVPSYTAAKHGVAGLTKLLANEWAAK----GINVNAIAPGYIET 187 >1K2W-A nrPDB Length = 256 Score = 131 bits (329), Expect = 3e-31, Method: Composition-based stats. Identities = 49/245 (20%), Positives = 78/245 (31%), Gaps = 52/245 (21%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M + AL+TG+ RGIG A A R+ V + ++ +A ++ G + Sbjct: 1 MRLDGKTALITGSARGIGRAFAEAYVRE-GARVAIADINLEAARATAAEI---GPAACAI 56 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 LD+ D SI L +G +++LVNNAA+ + + N T Sbjct: 57 ALDVTDQASIDRCVAELLDRWGSIDILVNNAALFDLAPIVEITRESYDRLFAINVSGTLF 116 Query: 121 MCNELLPIMKPHGR---VVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 M + M GR ++N++S R Sbjct: 117 MMQAVARAMIAGGRGGKIINMASQAGRRGEALVGV------------------------- 151 Query: 178 DTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDG 237 Y +K V L++ L I VNA PG V + Sbjct: 152 ----------------YCATKAAVISLTQSAGLNL----IRHGINVNAIAPGVVDGEHWD 191 Query: 238 KDSIR 242 + Sbjct: 192 GVDAK 196 >4AVY-A nrPDB Length = 242 Score = 131 bits (328), Expect = 5e-31, Method: Composition-based stats. Identities = 56/263 (21%), Positives = 88/263 (33%), Gaps = 61/263 (23%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 + LVTG + GIG AIA + + +VV D A R +LD Sbjct: 10 AGQQVLVTGGSSGIGAAIAMQFA-ELGAEVVALGLDADGVHAP------RHPRIRREELD 62 Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCN 123 I D Q ++ L + L L+VLVNNA ++ ++ E L+ N A Sbjct: 63 ITDSQRLQRLFEALP----RLDVLVNNAGISRDREEYDL--ATFERVLRLNLSAAMLASQ 116 Query: 124 ELLPIM-KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNE 182 P++ + G ++NI+S+ + Sbjct: 117 LARPLLAQRGGSILNIASMYSTFGSADRP------------------------------- 145 Query: 183 VHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIR 242 Y SK + L+R LA +R I VNA PG + T + ++ Sbjct: 146 ----------AYSASKGAIVQLTRSLACEYAAER----IRVNAIAPGWIDTPLGA--GLK 189 Query: 243 TVEEGAETPVYLALLPPDATEPQ 265 E + L P+ Sbjct: 190 ADVEATRRIMQRTPLARWGEAPE 212 >5EJ2-A nrPDB Length = 308 Score = 130 bits (326), Expect = 8e-31, Method: Composition-based stats. Identities = 48/287 (16%), Positives = 84/287 (29%), Gaps = 70/287 (24%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLT-----------ARDVARGQAAVQQLQA 52 +VA ++GA RG G + A L ++ + + + ++ Sbjct: 36 AGKVAFISGAARGQGRSHAVRLAQEGADIIAIDICGPIENLAYPHSTPEDLAETADLVKD 95 Query: 53 EGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDP-MPFDIKAEMTL 111 Q+D+ D +++++ D ++ G L+++V NA V D + + Sbjct: 96 LDRRIVTAQVDVRDFEALKSAVDSGVEQLGRLDIIVANAGVGTDGRKLHKIRDNVWQDMI 155 Query: 112 KTNFFATRNMCNELLPI---MKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDL 168 N + +P G +V SS+ +A+ N Sbjct: 156 DINLTGVWHTVKAGVPHVLSGGRGGSIVLTSSVGGRKAYPNTG----------------- 198 Query: 169 VDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCP 228 Y +K GV L R A L I VNA P Sbjct: 199 ------------------------HYIAAKHGVIGLMRAFAVELGPHM----IRVNAVLP 230 Query: 229 GPVKTDMDGKDSIRT----------VEEGAETPVYLALLPPDATEPQ 265 V T M D ++ A + LP + Sbjct: 231 TQVSTTMVMNDQTFRLFRPDLENPGPDDFAPISQMMHTLPVPWVDAS 277 >1A27-A nrPDB Length = 289 Score = 129 bits (325), Expect = 9e-31, Method: Composition-based stats. Identities = 52/178 (29%), Positives = 71/178 (39%), Gaps = 9/178 (5%) Query: 7 VALVTGANRGIGLAIARELCRQFSG--DVVLTARDVA---RGQAAVQQLQAEGLSPRFHQ 61 V L+TG + GIGL +A L S V T RD+ R A + L S Q Sbjct: 4 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQ 63 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 LD+ D +S+ A R+ + + G ++VLV NA + + L N T M Sbjct: 64 LDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRM 121 Query: 122 CNELLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 LP MK GRV+ S+ L +F E L E V L+ V Sbjct: 122 LQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH 179 >1AHH-A nrPDB Length = 255 Score = 128 bits (322), Expect = 2e-30, Method: Composition-based stats. Identities = 54/265 (20%), Positives = 89/265 (33%), Gaps = 57/265 (21%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 + A++TGA GIG IA VV++ + V ++Q G + Sbjct: 9 LDGKCAIITGAGAGIGKEIAITFATA-GASVVVSDINADAANHVVDEIQQLGGQAFACRC 67 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 DI Q + AL DF + G +++LVNNA MP + N F+ ++ Sbjct: 68 DITSEQELSALADFAISKLGKVDILVNNAGGGGPKPFDMPM-ADFRRAYELNVFSFFHLS 126 Query: 123 NELLPIMKP--HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 + P M+ G ++ I+S+ N + + + Sbjct: 127 QLVAPEMEKNGGGVILTITSMAAENKNINMTSYASSKAAASH------------------ 168 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD-----M 235 L R +A L EK I VN PG + TD + Sbjct: 169 -----------------------LVRNMAFDLGEK----NIRVNGIAPGAILTDALKSVI 201 Query: 236 DGKDSIRTVEEGAETPVYLALLPPD 260 + + ++ TP+ P D Sbjct: 202 TPEIEQKMLQ---HTPIRRLGQPQD 223 >4CQL-A nrPDB Length = 261 Score = 128 bits (322), Expect = 2e-30, Method: Composition-based stats. Identities = 51/265 (19%), Positives = 85/265 (32%), Gaps = 58/265 (21%) Query: 8 ALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEG-------LSPRFH 60 ALVTGA GIG A++ L + V D A Q V+ L G + Sbjct: 14 ALVTGAGSGIGRAVSVRLAGE-GATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAF 72 Query: 61 QLDIDDLQSIRALRDFLRKEYGGL-NVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATR 119 Q D+ + ++ R L + ++ + +V+V+ A + + + + N T Sbjct: 73 QADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTF 132 Query: 120 NMCNELLPIMKP---HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFV 176 + + G ++NISS+ + Sbjct: 133 LVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAAS-------------------- 172 Query: 177 EDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMD 236 K GV L++ AR L I N+ PG + T M Sbjct: 173 ---------------------KAGVIGLTQTAARELGRH----GIRCNSVLPGFIATPMT 207 Query: 237 GKDSIRTVEEGAE-TPVYLALLPPD 260 K + V++ E P+ P D Sbjct: 208 QKVPQKVVDKITEMIPMGHLGDPED 232 >6CGE-A nrPDB Length = 328 Score = 128 bits (322), Expect = 2e-30, Method: Composition-based stats. Identities = 52/178 (29%), Positives = 71/178 (39%), Gaps = 9/178 (5%) Query: 7 VALVTGANRGIGLAIARELCRQFSG--DVVLTARDVA---RGQAAVQQLQAEGLSPRFHQ 61 V L+TG + GIGL +A L S V T RD+ R A + L S Q Sbjct: 5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQ 64 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 LD+ D +S+ A R+ + + G ++VLV NA + + L N T M Sbjct: 65 LDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRM 122 Query: 122 CNELLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 LP MK GRV+ S+ L +F E L E V L+ V Sbjct: 123 LQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH 180 >1H5Q-A nrPDB Length = 265 Score = 127 bits (320), Expect = 3e-30, Method: Composition-based stats. Identities = 52/276 (18%), Positives = 90/276 (32%), Gaps = 44/276 (15%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE-GLSPRF 59 +S ++ +VTG NRGIGLA R + + V+ R A +++ E G+ + Sbjct: 10 ISFVNKTIIVTGGNRGIGLAFTRAVAAAGANVAVIY-RSAADAVEVTEKVGKEFGVKTKA 68 Query: 60 HQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATR 119 +Q D+ + + + + G ++ L+ NA V+ N F Sbjct: 69 YQCDVSNTDIVTKTIQQIDADLGPISGLIANAGVSVVKPATELTHEDFAFVYDVNVFGVF 128 Query: 120 NMCNELLPI---MKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFV 176 N C + + + G +V SS+ ++ + Sbjct: 129 NTCRAVAKLWLQKQQKGSIVVTSSMSSQIINQSSLNGSLTQVF----------------- 171 Query: 177 EDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMD 236 Y SK + L + LA I VNA PG V TD Sbjct: 172 -----------------YNSSKAACSNLVKGLAAEWASA----GIRVNALSPGYVNTDQT 210 Query: 237 GKDSIR-TVEEGAETPVYLALLPPDATEPQGQLVHD 271 + + + P+ P + T L+ D Sbjct: 211 AHMDKKIRDHQASNIPLNRFAQPEEMTGQAILLLSD 246 >4E6P-A nrPDB Length = 259 Score = 127 bits (318), Expect = 6e-30, Method: Composition-based stats. Identities = 51/241 (21%), Positives = 79/241 (32%), Gaps = 52/241 (21%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 + AL+TG+ RGIG A A R+ V + D+ R + A ++ G + Q+ Sbjct: 6 LEGKSALITGSARGIGRAFAEAYVRE-GATVAIADIDIERARQAAAEI---GPAAYAVQM 61 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 D+ SI A + GGL++LVNNAA+ + E N T Sbjct: 62 DVTRQDSIDAAIAATVEHAGGLDILVNNAALFDLAPIVEITRESYEKLFAINVAGTLFTL 121 Query: 123 NELLPIM---KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 M G+++N++S R Sbjct: 122 QAAARQMIAQGRGGKIINMASQAGRRGEALV----------------------------- 152 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKD 239 + Y +K V L++ L + R I VNA PG V + Sbjct: 153 ------------AIYCATKAAVISLTQSAGLDLIKHR----INVNAIAPGVVDGEHWDGV 196 Query: 240 S 240 Sbjct: 197 D 197 >1HXH-A nrPDB Length = 253 Score = 127 bits (318), Expect = 7e-30, Method: Composition-based stats. Identities = 43/190 (22%), Positives = 72/190 (37%), Gaps = 5/190 (2%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 +VALVTG G+GL + + L + V + + A GQ +L G F + Sbjct: 4 LQGKVALVTGGASGVGLEVVKLLLGE-GAKVAFSDINEAAGQQLAAEL---GERSMFVRH 59 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 D+ + +++ G LNVLVNNA + D LK N + C Sbjct: 60 DVSSEADWTLVMAAVQRRLGTLNVLVNNAGILLPGDMETGRLEDFSRLLKINTESVFIGC 119 Query: 123 NELLPIMKP-HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKN 181 + + MK G ++N++S+ E + + LT + K+ N Sbjct: 120 QQGIAAMKETGGSIINMASVSSWLPIEQYAGYSASKAAVSALTRAAALSCRKQGYAIRVN 179 Query: 182 EVHEREGWPN 191 +H + Sbjct: 180 SIHPDGIYTP 189 >3UN1-A nrPDB Length = 260 Score = 125 bits (314), Expect = 2e-29, Method: Composition-based stats. Identities = 52/261 (19%), Positives = 85/261 (32%), Gaps = 65/261 (24%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M + +V ++TGA++GIG + R R + VV T+R + Sbjct: 24 MRNQQKVVVITGASQGIGAGLVRAY-RDRNYRVVATSRSIKPSAD---------PDIHTV 73 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 DI ++ + + +G ++ LVNNA V + L N + Sbjct: 74 AGDISKPETADRIVREGIERFGRIDSLVNNAGVFLAKPFVEMTQEDYDHNLGVNVAGFFH 133 Query: 121 MCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + M + G +V+I+ Sbjct: 134 ITQRAAAEMLKQGSGHIVSIT--------------------------------------- 154 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 T G P++ ++K G+ ++R LA + VNA PG +KT M Sbjct: 155 TSLVDQPMVGMPSALASLTKGGLNAVTRSLAMEFSR----SGVRVNAVSPGVIKTPM--- 207 Query: 239 DSIRTVEEGAETPVYLALLPP 259 AET LA L P Sbjct: 208 -------HPAETHSTLAGLHP 221 >3UF0-A nrPDB Length = 273 Score = 125 bits (313), Expect = 3e-29, Method: Composition-based stats. Identities = 61/276 (22%), Positives = 86/276 (31%), Gaps = 53/276 (19%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 S R A+VTGA GIG AIA R + + D + ++ G S Sbjct: 27 FSLAGRTAVVTGAGSGIGRAIAHGYARAGAHVLAWGRTD--GVKEVADEIADGGGSAEAV 84 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 D+ DL+ + + L ++VLVNNA + ++ + L N A Sbjct: 85 VADLADLEGAANVAEELAATR-RVDVLVNNAGIIARAPAEEVSLGRWREVLTVNLDAAWV 143 Query: 121 MCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + M GR+V I+S+ + N + Sbjct: 144 LSRSFGTAMLAHGSGRIVTIASMLSFQGGRNVAAYAA----------------------- 180 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDG- 237 SK V L+R LA + + VNA PG V T Sbjct: 181 ------------------SKHAVVGLTRALASEWAGR----GVGVNALAPGYVVTANTAA 218 Query: 238 --KDSIRTVEEGAETPVYLALLPPDATEPQGQLVHD 271 D R E A P P D P L D Sbjct: 219 LRADDERAAEITARIPAGRWATPEDMVGPAVFLASD 254 >3RKU-A nrPDB Length = 287 Score = 123 bits (308), Expect = 9e-29, Method: Composition-based stats. Identities = 56/241 (23%), Positives = 90/241 (37%), Gaps = 52/241 (21%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGD--VVLTARDVARGQAAVQQLQAEGLSPRFH 60 + L+TGA+ GIG A A E +GD ++L AR + + + + + E + + H Sbjct: 31 LAKKTVLITGASAGIGKATALEYLEASNGDMKLILAARRLEKLEELKKTIDQEFPNAKVH 90 Query: 61 --QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPF-DIKAEMTLKTNFFA 117 QLDI + I+ + L +E+ +++LVNNA A SD + TN A Sbjct: 91 VAQLDITQAEKIKPFIENLPQEFKDIDILVNNAGKALGSDRVGQIATEDIQDVFDTNVTA 150 Query: 118 TRNMCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKF 175 N+ +LPI K G +VN+ S+ A+ S +F Sbjct: 151 LINITQAVLPIFQAKNSGDIVNLGSIAGRDAYPTGSIYCASKF----------------- 193 Query: 176 VEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 V + L + L +I V PG V+T+ Sbjct: 194 ------------------------AVGAFTDSLRKEL----INTKIRVILIAPGLVETEF 225 Query: 236 D 236 Sbjct: 226 S 226 >3OML-A nrPDB Length = 613 Score = 122 bits (305), Expect = 2e-28, Method: Composition-based stats. Identities = 37/234 (15%), Positives = 68/234 (29%), Gaps = 58/234 (24%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLT--------ARDVARGQAAVQQLQAEGLS 56 RVA+VTGA G+G A + + VV V +++ G Sbjct: 19 GRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRKAGGE 78 Query: 57 PRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFF 116 + D + + K +G +++LVNNA + + + + Sbjct: 79 AVADYNSVIDGAKV---IETAIKAFGRVDILVNNAGILRDRSLVKTSEQDWNLVNDVHLK 135 Query: 117 ATRNMCNELLPIMKP--HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKK 174 + P MK +GR++ SS + Sbjct: 136 GSFKCTQAAFPYMKKQNYGRIIMTSSNSGIYG---------------------------- 167 Query: 175 FVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCP 228 + Y +K+G+ L+ +A + +L N P Sbjct: 168 -------------NFGQVNYTAAKMGLIGLANTVAIEGAR----NNVLCNVIVP 204 >5ILO-A nrPDB Length = 271 Score = 120 bits (300), Expect = 8e-28, Method: Composition-based stats. Identities = 48/239 (20%), Positives = 81/239 (33%), Gaps = 56/239 (23%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 S + A+VTG GIGL ++++L + V + + + S + Sbjct: 12 SFRGKNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEFVKLRAAHPTQSVMIIK 71 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 +D+ + + + A + + K +G ++++VN A + D + TL N N Sbjct: 72 MDVANKKGVEATYEEIAKTFGNIDIVVNVAGIFN--------DKDVQRTLLVNLGGIINS 123 Query: 122 CNELLPIM-----KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFV 176 LP M G VVN+SS+ L Sbjct: 124 TLSALPYMGKDNGGKGGIVVNMSSVVGLDPM----------------------------- 154 Query: 177 EDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 + YG +K G+ +R LA + + I CPG TDM Sbjct: 155 ------------FIIPVYGATKAGIINFTRCLANE--KYYQRSGIKFVTVCPGATMTDM 199 >3ZV3-A nrPDB Length = 281 Score = 120 bits (300), Expect = 8e-28, Method: Composition-based stats. Identities = 44/247 (17%), Positives = 69/247 (27%), Gaps = 56/247 (22%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M VAL+TG G+G A+ + V + + R + A G + Sbjct: 1 MKLTGEVALITGGASGLGRALVDRFVAE-GARVAVLDKSAERLRELE---VAHGGNAVGV 56 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMP-----FDIKAEMTLKTNF 115 D+ LQ + + +G ++ L+ NA + S D + N Sbjct: 57 VGDVRSLQDQKRAAERCLAAFGKIDTLIPNAGIWDYSTALADLPEDKIDAAFDDIFHVNV 116 Query: 116 FATRNMCNELLPIM-KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKK 174 + LP + G VV S Sbjct: 117 KGYIHAVKACLPALVSSRGSVVFTISNAGF------------------------------ 146 Query: 175 FVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD 234 Y +K V L R +A L + VN PG + TD Sbjct: 147 -----------YPNGGGPLYTATKHAVVGLVRQMAFELAPH-----VRVNGVAPGGMNTD 190 Query: 235 MDGKDSI 241 + G S+ Sbjct: 191 LRGPSSL 197 >4IS3-A nrPDB Length = 268 Score = 119 bits (298), Expect = 1e-27, Method: Composition-based stats. Identities = 47/266 (17%), Positives = 83/266 (31%), Gaps = 52/266 (19%) Query: 1 MSSCS-RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE--GLSP 57 M+ +V ++TG RGIG A A+ V + A+ QL+ Sbjct: 20 MNLVQDKVTIITGGTRGIGFAAAKIFI-DNGAKVSIFGETQEEVDTALAQLKELYPEEEV 78 Query: 58 RFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFA 117 D+ ++ A + ++YG L+V++NNA + + + + + + N Sbjct: 79 LGFAPDLTSRDAVMAAVGQVAQKYGRLDVMINNAGITSNNVFSRVSEEEFKHIMDINVTG 138 Query: 118 TRNMCNELLPIMK--PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKF 175 N MK G ++N +S+ + + + Sbjct: 139 VFNGAWCAYQCMKDAKKGVIINTASVTGIFGSLSGVGYPASK------------------ 180 Query: 176 VEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 V L+ L R + K I V PG V TDM Sbjct: 181 -----------------------ASVIGLTHGLGREIIRK----NIRVVGVAPGVVNTDM 213 Query: 236 DGKDSIRTVE-EGAETPVYLALLPPD 260 + +E P+ L P + Sbjct: 214 TNGNPPEIMEGYLKALPMKRMLEPEE 239 >2NWQ-A nrPDB Length = 272 Score = 118 bits (295), Expect = 3e-27, Method: Composition-based stats. Identities = 48/186 (25%), Positives = 74/186 (39%), Gaps = 8/186 (4%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 S S +TGA G G A AR + +VLT R R QA +L A+ Sbjct: 18 SHMSSTLFITGATSGFGEACARRFA-EAGWSLVLTGRREERLQALAGELSAK-TRVLPLT 75 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSD-----DPMPFDIKAEMTLKTNFF 116 LD+ D ++ A D L +E+ L L+NNA +A +D D +D + +K + Sbjct: 76 LDVRDRAAMSAAVDNLPEEFATLRGLINNAGLALGTDPAQSCDLDDWDTMVDTNIKGLLY 135 Query: 117 ATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFV 176 +TR + L+ +VN+ S+ + + E + DL V Sbjct: 136 STRLLLPRLIAHG-AGASIVNLGSVAGKWPYPGSHVYGGTKAFVEQFSLNLRCDLQGTGV 194 Query: 177 EDTKNE 182 T E Sbjct: 195 RVTNLE 200 >3KZV-A nrPDB Length = 254 Score = 117 bits (294), Expect = 3e-27, Method: Composition-based stats. Identities = 53/236 (22%), Positives = 81/236 (34%), Gaps = 53/236 (22%) Query: 4 CSRVALVTGANRGIGLAIARELCR-QFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 +V LVTG +RGIG +I L V AR A + ++ G + Sbjct: 1 MGKVILVTGVSRGIGKSIVDVLFSLDKDTVVYGVARSEAPLKKLKEK---YGDRFFYVVG 57 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIK-AEMTLKTNFFATRNM 121 DI + ++ L + K +G ++ LV NA V + D+ + NFF+ ++ Sbjct: 58 DITEDSVLKQLVNAAVKGHGKIDSLVANAGVLEPVQNVNEIDVNAWKKLYDINFFSIVSL 117 Query: 122 CNELLPIMKP-HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 LP +K +G VV +SS C F + Sbjct: 118 VGIALPELKKTNGNVVFVSSDACNMYFSSWG----------------------------- 148 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMD 236 YG SK + + LA ++ A PG V TDM Sbjct: 149 ------------AYGSSKAALNHFAMTLANE------ERQVKAIAVAPGIVDTDMQ 186 >3GDF-A nrPDB Length = 267 Score = 116 bits (289), Expect = 1e-26, Method: Composition-based stats. Identities = 39/242 (16%), Positives = 80/242 (33%), Gaps = 49/242 (20%) Query: 1 MSSCSRVALVTGAN--RGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQA-EGLSP 57 +S +V +VTGA+ +G+G+ AR + + A + V++L+ G+ Sbjct: 16 LSLKGKVVVVTGASGPKGMGIEAARGCAEMGAAVAITYASRAQGAEENVKELEKTYGIKA 75 Query: 58 RFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFA 117 + ++ +D +S L + ++G ++ + NA S ++ + Sbjct: 76 KAYKCQVDSYESCEKLVKDVVADFGQIDAFIANAGATADSGILDGSVEAWNHVVQVDLNG 135 Query: 118 TRNMCNELLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKF 175 T + + K G +V +S+ A Sbjct: 136 TFHCAKAVGHHFKERGTGSLVITASMSGHIA----------------------------- 166 Query: 176 VEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 + Y V+K G ++R LA + VN+ PG + T + Sbjct: 167 ----------NFPQEQTSYNVAKAGCIHMARSLANEWRDFA-----RVNSISPGYIDTGL 211 Query: 236 DG 237 Sbjct: 212 SD 213 >1E3W-A nrPDB Length = 261 Score = 116 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 42/248 (16%), Positives = 82/248 (33%), Gaps = 63/248 (25%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 S VA++TG G+GL+ A+ L Q + V+L + A + G + F Sbjct: 7 SVKGLVAVITGGASGLGLSTAKRLVGQGATAVLLDVPNSEGETEA----KKLGGNCIFAP 62 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVA------FKSDDPMPFDIKAEMTLKTNF 115 ++ + ++A ++++G ++V VN A +A + + + + + N Sbjct: 63 ANVTSEKEVQAALTLAKEKFGRIDVAVNCAGIAVAIKTYHEKKNQVHTLEDFQRVINVNL 122 Query: 116 FATRNMCNELLPIMKP--------HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGD 167 T N+ + +M G ++N +S+ Sbjct: 123 IGTFNVIRLVAGVMGQNEPDQGGQRGVIINTASVAAFEG--------------------- 161 Query: 168 LVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACC 227 + Y SK G+ ++ +AR L I V Sbjct: 162 --------------------QVGQAAYSASKGGIVGMTLPIARDLAP----IGIRVVTIA 197 Query: 228 PGPVKTDM 235 PG T + Sbjct: 198 PGLFATPL 205 >4DA9-A nrPDB Length = 280 Score = 115 bits (287), Expect = 3e-26, Method: Composition-based stats. Identities = 64/263 (24%), Positives = 94/263 (35%), Gaps = 54/263 (20%) Query: 7 VALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDD 66 VA+VTG RGIGL IAR L + D + +L G F + D+ D Sbjct: 31 VAIVTGGRRGIGLGIARALAASGFDIAITGIGDAEGVAPVIAELSGLGARVIFLRADLAD 90 Query: 67 LQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDD------PMPFDIKAEMTLKTNFFATRN 120 L S +A D + E+G ++ LVNNA +A D P FD + L+ F T+ Sbjct: 91 LSSHQATVDAVVAEFGRIDCLVNNAGIASIVRDDFLDLKPENFDTIVGVNLRGTVFFTQA 150 Query: 121 MCNELLPIMKPHGR-VVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 + +L R ++NI+S+ + + Sbjct: 151 VLKAMLASDARASRSIINITSVSAVMTSPERLDYCM------------------------ 186 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKD 239 SK G+ S+ LA RL E I V PG +++DM Sbjct: 187 -----------------SKAGLAAFSQGLALRLAE----TGIAVFEVRPGIIRSDMTAAV 225 Query: 240 SIRTVE--EGAETPVYLALLPPD 260 S + E P+ P D Sbjct: 226 SGKYDGLIESGLVPMRRWGEPED 248 >5JY1-A nrPDB Length = 274 Score = 114 bits (286), Expect = 3e-26, Method: Composition-based stats. Identities = 62/272 (22%), Positives = 94/272 (34%), Gaps = 52/272 (19%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 RVALVTGA GIG +AR + + V++ + + G+ Q+++ G F + Sbjct: 12 LEQRVALVTGAGGGIGRGVARSFGNEGAA-VIIAEINESTGRQVEQEIREMGGRSLFVKT 70 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAV-AFKSDDPMPFDIKAEMTLKTNFFATRNM 121 D+ SI A +++G L++LVNNA V D E TL T+ +AT Sbjct: 71 DVTSKASIEAAVRSAVEQFGSLDILVNNAFVPTPNVLLEEKTDEMLEQTLTTSLWATWWA 130 Query: 122 CNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 M + GR+VN S+ Sbjct: 131 MRAAFVPMRERRWGRIVNFYSI-------------------------------------- 152 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCP---GPVKTDMD 236 E W + Y +K G+ L+R A I VNA P G ++ Sbjct: 153 ---DTETGAWLHGDYNTAKAGIVGLTRSAASEWGRF----NITVNAIAPTAMGATFFELA 205 Query: 237 GKDSIRTVEEGAETPVYLALLPPDATEPQGQL 268 K+ A P+ + P P Sbjct: 206 AKNPEFAERSAAARPLGRSGDPEQDIGPAAVF 237 >2O23-A nrPDB Length = 265 Score = 114 bits (285), Expect = 4e-26, Method: Composition-based stats. Identities = 48/278 (17%), Positives = 82/278 (29%), Gaps = 63/278 (22%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 S VA++TG G+GLA A L Q + V+L + A + G + F Sbjct: 9 SVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQA----KKLGNNCVFAP 64 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMP------FDIKAEMTLKTNF 115 D+ + ++ + ++G ++V VN A +A S + L N Sbjct: 65 ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNL 124 Query: 116 FATRNMCNELLPIMKP--------HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGD 167 T N+ + M G ++N +S+ Sbjct: 125 MGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEG--------------------- 163 Query: 168 LVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACC 227 + Y SK G+ ++ +AR L I V Sbjct: 164 --------------------QVGQAAYSASKGGIVGMTLPIARDLAP----IGIRVMTIA 199 Query: 228 PGPVKTDMDGKDSIRTVEEGAETPVYLALLPPDATEPQ 265 PG T + + A + + L A Sbjct: 200 PGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAH 237 >4RGB-A nrPDB Length = 294 Score = 111 bits (276), Expect = 4e-25, Method: Composition-based stats. Identities = 49/249 (19%), Positives = 79/249 (31%), Gaps = 57/249 (22%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTA------------RDVARGQAAVQQ 49 S RV +TGA RG G + A +C + ++V + + Sbjct: 22 SLDGRVVFITGAARGQGRSHAV-MCAEQGANIVGVDICEDIDIVPYKLGTYEELEETARL 80 Query: 50 LQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEM 109 ++ G F + D+ D ++ + D +++G ++ ++ NA V + D + Sbjct: 81 VEKTGQEMLFRKADVRDKAVLQEVFDAGVEQFGHIDTVIANAGVVLTNPDERDASEALRL 140 Query: 110 TLKTNFFATRNMCNELLPIMK---PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEG 166 L N +P MK G ++ SS+ L + Sbjct: 141 GLDIMLIGVWNTFQVAIPHMKERGQGGNLIATSSMIALLDLTDGRGGTD----------- 189 Query: 167 DLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNAC 226 Y SKL +T L R A L ADRI VN Sbjct: 190 --------------------------AYLTSKLAITGLVRSYALMLA----ADRIRVNGV 219 Query: 227 CPGPVKTDM 235 P T M Sbjct: 220 APTNCSTPM 228 >3PXX-A nrPDB Length = 287 Score = 110 bits (275), Expect = 6e-25, Method: Composition-based stats. Identities = 46/244 (18%), Positives = 80/244 (32%), Gaps = 53/244 (21%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVV--------------LTARDVARGQAAVQQLQ 51 +V LVTG RG G + A +L + + ++ T+RD+ A +++ Sbjct: 11 KVVLVTGGARGQGRSHAVKLAEEGADIILFDICHDIETNEYPLATSRDLE---EAGLEVE 67 Query: 52 AEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTL 111 G ++D+ D ++ E+G L+V+V NA + +P A+ Sbjct: 68 KTGRKAYTAEVDVRDRAAVSRELANAVAEFGKLDVVVANAGICPLG-AHLPVQAFADA-F 125 Query: 112 KTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDL 171 +F N + LP + ++ S+ L A + Sbjct: 126 DVDFVGVINTVHAALPYLTSGASIITTGSVAGLIAAAQPPGAGGPQGPGGAG-------- 177 Query: 172 MKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPV 231 Y +K V + LA +L + I N P V Sbjct: 178 ----------------------YSYAKQLVDSYTLQLAAQLAPQ----SIRANVIHPTNV 211 Query: 232 KTDM 235 TDM Sbjct: 212 NTDM 215 >1CYD-A nrPDB Length = 244 Score = 107 bits (268), Expect = 4e-24, Method: Composition-based stats. Identities = 46/243 (18%), Positives = 78/243 (32%), Gaps = 57/243 (23%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 ++ ALVTGA +GIG + L + V +T + + L E Sbjct: 3 LNFSGLRALVTGAGKGIGRDTVKALHASGAKVVAVTRTNSD-----LVSLAKECPGIEPV 57 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 +D+ D + + G +++LVNNAA+ + + N + Sbjct: 58 CVDLGDWDATEKALGGI----GPVDLLVNNAALVIMQPFLEVTKEAFDRSFSVNLRSVFQ 113 Query: 121 MCNELLPIMKPH---GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177 + + M G +VN+SS+ F N + Sbjct: 114 VSQMVARDMINRGVPGSIVNVSSMVAHVTFPNLITYSSTK-------------------- 153 Query: 178 DTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDG 237 +T+L++ +A L +I VN+ P V TDM Sbjct: 154 ---------------------GAMTMLTKAMAMELGPH----KIRVNSVNPTVVLTDMGK 188 Query: 238 KDS 240 K S Sbjct: 189 KVS 191 >3D3W-A nrPDB Length = 244 Score = 106 bits (263), Expect = 1e-23, Method: Composition-based stats. Identities = 50/240 (20%), Positives = 79/240 (32%), Gaps = 57/240 (23%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 R LVTGA +GIG + L VV +R A + V++ G+ P Sbjct: 5 LAGRRVLVTGAGKGIGRGTVQAL-HATGARVVAVSRTQADLDSLVRE--CPGIEPVCV-- 59 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 D+ D ++ + G +++LVNNAAVA + + + N A + Sbjct: 60 DLGDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVS 115 Query: 123 NELLPIMKPH---GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 + + G +VN+SS RA N S + + Sbjct: 116 QIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDM----------------- 158 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKD 239 L++++A L +I VNA P V T M Sbjct: 159 ------------------------LTKVMALELGPH----KIRVNAVNPTVVMTSMGQAT 190 >5JS6-A nrPDB Length = 274 Score = 105 bits (261), Expect = 2e-23, Method: Composition-based stats. Identities = 39/221 (17%), Positives = 68/221 (30%), Gaps = 51/221 (23%) Query: 30 SGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVN 89 VV+ +D + G+A L+ E F D+ ++ L + +G L+ +VN Sbjct: 35 GARVVICDKDESGGRA----LEQELPGAVFILCDVTQEDDVKTLVSETIRRFGRLDCVVN 90 Query: 90 NAAVAFKSDDPMPFDIK-AEMTLKTNFFATRNMCNELLPIMKPH-GRVVNISSLQCLRAF 147 NA P + L+ N T + LP ++ G V+NISSL Sbjct: 91 NAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALPYLRKSQGNVINISSLVGAIGQ 150 Query: 148 ENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRI 207 + + VT +++ Sbjct: 151 AQAVPYVATK-----------------------------------------GAVTAMTKA 169 Query: 208 LARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTVEEGA 248 LA + VN PG + T + + + + A Sbjct: 170 LALDESPY----GVRVNCISPGNIWTPLWEELAALMPDPRA 206 >1BDB-A nrPDB Length = 277 Score = 104 bits (258), Expect = 6e-23, Method: Composition-based stats. Identities = 37/247 (14%), Positives = 65/247 (26%), Gaps = 56/247 (22%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M L+TG G+G A+ + + VL + + G + Sbjct: 1 MKLKGEAVLITGGASGLGRALVDRFVAEGAKVAVL----DKSAERLAELETDHGDNVLGI 56 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMP-----FDIKAEMTLKTNF 115 D+ L+ + +G ++ L+ NA + S + D + N Sbjct: 57 VGDVRSLEDQKQAASRCVARFGKIDTLIPNAGIWDYSTALVDLPEESLDAAFDEVFHINV 116 Query: 116 FATRNMCNELLPIM-KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKK 174 + LP + G V+ S Sbjct: 117 KGYIHAVKACLPALVASRGNVIFTISNAGF------------------------------ 146 Query: 175 FVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD 234 Y +K + L R LA L + VN G + +D Sbjct: 147 -----------YPNGGGPLYTAAKHAIVGLVRELAFELAPY-----VRVNGVGSGGINSD 190 Query: 235 MDGKDSI 241 + G S+ Sbjct: 191 LRGPSSL 197 >4EGF-A nrPDB Length = 266 Score = 102 bits (255), Expect = 1e-22, Method: Composition-based stats. Identities = 58/260 (22%), Positives = 93/260 (35%), Gaps = 47/260 (18%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQL-QAEGLSPRFHQ 61 + AL+TGA +GIG IAR +VL+ RDV+ AA + L + G Sbjct: 18 LDGKRALITGATKGIGADIARA-FAAAGARLVLSGRDVSELDAARRALGEQFGTDVHTVA 76 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 +D+ + + L + +GGL+VLVNNA ++ + T+ N A + Sbjct: 77 IDLAEPDAPAELARRAAEAFGGLDVLVNNAGISHPQPVVDTDPQLFDATIAVNLRAPALL 136 Query: 122 CNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKN 181 + + M G EG + + Sbjct: 137 ASAVGKAMVAAG-------------------------------EGGAIITVASAAALAPL 165 Query: 182 EVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDG---K 238 H Y SK G+ + +++LAR L I N+ CP V T+M Sbjct: 166 PDHY-------AYCTSKAGLVMATKVLARELGPH----GIRANSVCPTVVLTEMGQRVWG 214 Query: 239 DSIRTVEEGAETPVYLALLP 258 D ++ A P+ +P Sbjct: 215 DEAKSAPMIARIPLGRFAVP 234 >4FC7-A nrPDB Length = 277 Score = 101 bits (252), Expect = 3e-22, Method: Composition-based stats. Identities = 46/229 (20%), Positives = 75/229 (32%), Gaps = 49/229 (21%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQ-AEGLSPRFHQLDI 64 +VA +TG GIG IA R V+ +R + R A ++L A G +D+ Sbjct: 28 KVAFITGGGSGIGFRIAEIFMR-HGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSMDV 86 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE 124 ++ A D KE+G +++L+N AA F + + + T N+ Sbjct: 87 RAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNVSRV 146 Query: 125 LLPIMKP--HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNE 182 L G +VNI++ R + Sbjct: 147 LYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAA----------------------- 183 Query: 183 VHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPV 231 V ++R LA + I VN+ PGP+ Sbjct: 184 ------------------VDAMTRHLAVEWGPQ----NIRVNSLAPGPI 210 >3DWF-A nrPDB Length = 276 Score = 100 bits (249), Expect = 6e-22, Method: Composition-based stats. Identities = 33/163 (20%), Positives = 64/163 (39%), Gaps = 3/163 (1%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEG-LSPRFHQ 61 + +VTGA++GIG IA L + VV+TAR Q V + G S + Sbjct: 9 LQGKKVIVTGASKGIGREIAYHLAK-MGAHVVVTARSKEALQKVVARCLELGAASAHYIA 67 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 ++D+ GGL++L+ N + + +++ NF + + Sbjct: 68 GSMEDMTFAEEFVAEAGNLMGGLDMLILNHVLYNRLTFFHGEIDNVRKSMEVNFHSFVVL 127 Query: 122 CNELLP-IMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETL 163 +P +M+ G + +SS+ + + +F + Sbjct: 128 SVAAMPMLMQSQGSIAVVSSVAGKITYPLIAPYSASKFALDGF 170 >5IZ4-A nrPDB Length = 271 Score = 100 bits (249), Expect = 6e-22, Method: Composition-based stats. Identities = 54/296 (18%), Positives = 85/296 (28%), Gaps = 74/296 (25%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVAR-GQAAVQQL-QAEGLSPRF 59 S + V ++TG+ GIG A A + + D R + V+ L + G Sbjct: 11 QSSTPVCVITGSASGIGAATALRFAQAGWSVAIGNFDDSTRDAASTVEALCRDAGAQTLI 70 Query: 60 HQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAA---VAFKSDDPMPFDIKAEMTLKTNFF 116 D+ R D + + ++ L+N A V + D + E + N Sbjct: 71 FDADVGKDADCRHAVDMVASRWQRIDALINCAGTTRVIPHNAFDQIDDFEFERVYRVNLI 130 Query: 117 ATRNMCNELLPIMKPHG------RVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVD 170 M +P+++ VVN+SSL L + + Sbjct: 131 GLYQMTRAAVPLLRESASATRSTSVVNVSSLAGLNGTGSSIAYAASK------------- 177 Query: 171 LMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGP 230 V L+ LAR L I VNA PG Sbjct: 178 ----------------------------GAVNTLTLSLARNLAPH-----IRVNALAPGM 204 Query: 231 VK-----------------TDMDGKDSIRTVEEGAETPVYLALLPPDATEPQGQLV 269 V + M ++ V AE L A GQ++ Sbjct: 205 VDDGLLLRVLDAAAYDGVLSRMTESAPLKRVSRPAEIAELAWFLTAHAPAITGQVI 260 >5O3Z-A nrPDB Length = 263 Score = 100 bits (249), Expect = 7e-22, Method: Composition-based stats. Identities = 45/254 (17%), Positives = 84/254 (33%), Gaps = 52/254 (20%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE--GLSPRFHQ 61 +VA+V G + +G + L Q V + + + + + + Sbjct: 5 MEQVAVVIGGGQTLGAFLCEGLA-QAGYHVAVADLNESNANRLADTINSRYGAGRAYGFK 63 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 +D D S+ AL + + +G ++LV +A VA + +++L+ N Sbjct: 64 VDATDEASVEALARAVDETFGRADLLVYSAGVAKAAPITQFRLTDFDLSLQVNLVGYFLC 123 Query: 122 CNELLPIMKP---HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 E +M GR++ I+S ++ Sbjct: 124 SREFSKLMIRDGIKGRIIQINSKSGKVGSKH----------------------------- 154 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPG-PVKTDMDG 237 NS Y +K G L++ LA L E I V++ G +K+ M Sbjct: 155 ------------NSGYSAAKFGGVGLTQSLALDLAEY----GITVHSLMLGNLLKSPMFQ 198 Query: 238 KDSIRTVEEGAETP 251 + E+ TP Sbjct: 199 SLLPQYAEKLGITP 212 >2FWM-X nrPDB Length = 250 Score = 99.5 bits (246), Expect = 1e-21, Method: Composition-based stats. Identities = 41/238 (17%), Positives = 64/238 (26%), Gaps = 58/238 (24%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M + VTGA +GIG A A + +T D A E Sbjct: 3 MDFSGKNVWVTGAGKGIGYATALAFVEAGAK---VTGFDQA--------FTQEQYPFATE 51 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 +D+ D + + L E L+ LVN A + + T N N Sbjct: 52 VMDVADAAQVAQVCQRLLAETERLDALVNAAGILRMGATDQLSKEDWQQTFAVNVGGAFN 111 Query: 121 MCNELLPIMK--PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + + + + G +V ++S S Sbjct: 112 LFQQTMNQFRRQRGGAIVTVASDAAHTPRIGMSAY------------------------- 146 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMD 236 G SK + + LA + + + N PG TDM Sbjct: 147 ----------------GASKAAL----KSLALSVGLELAGSGVRCNVVSPGSTDTDMQ 184 >1O5I-A nrPDB Length = 249 Score = 99.1 bits (245), Expect = 2e-21, Method: Composition-based stats. Identities = 45/271 (16%), Positives = 87/271 (32%), Gaps = 65/271 (23%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 + LV A+RGIG A+A L Q +V + AR+ + R+ D+ Sbjct: 20 KGVLVLAASRGIGRAVADVL-SQEGAEVTICARNEELLKR---------SGHRYVVCDLR 69 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNEL 125 + L + +++ +++LV NA + + + + F + Sbjct: 70 K--DLDLLFEKVKE----VDILVLNAGGPKAGFFDELTNEDFKEAIDSLFLNMIKIVRNY 123 Query: 126 LPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEV 183 LP M K GR+V I+S + EN Sbjct: 124 LPAMKEKGWGRIVAITSFSVISPIENLYTS------------------------------ 153 Query: 184 HEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK--DSI 241 +++ +T + L+ + I VN PG +T+ + Sbjct: 154 -----------NSARMALTGFLKTLSFEVAPY----GITVNCVAPGWTETERVKELLSEE 198 Query: 242 RTVEEGAETPVYLALLPPDATEPQGQLVHDK 272 + + ++ P+ P + L +K Sbjct: 199 KKKQVESQIPMRRMAKPEEIASVVAFLCSEK 229 >5PGZ-A nrPDB Length = 276 Score = 98.3 bits (243), Expect = 4e-21, Method: Composition-based stats. Identities = 48/235 (20%), Positives = 76/235 (32%), Gaps = 48/235 (20%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGL-SPRFHQ 61 + +VTGA++GIG +A L + VVLTAR Q V + G S + Sbjct: 16 LQGKKVIVTGASKGIGREMAYHL-SKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIA 74 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIK-AEMTLKTNFFATRN 120 ++D+ K GGL++L+ N + S DI ++ NF + Sbjct: 75 GTMEDMTFAEQFIVKAGKLMGGLDMLILNH-ITQTSLSLFHDDIHSVRRVMEVNFLSYVV 133 Query: 121 MCNELLPIMKPH-GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 M LP++K G + ISSL Sbjct: 134 MSTAALPMLKQSNGSIAVISSLAGKMTQPMI----------------------------- 164 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD 234 +PY SK + + L + I + G + T+ Sbjct: 165 ------------APYSASKFALDGFFSTIRTELYITKVNVSITL-CVL-GLIDTE 205 >4DRY-A nrPDB Length = 281 Score = 97.5 bits (241), Expect = 5e-21, Method: Composition-based stats. Identities = 51/261 (19%), Positives = 79/261 (30%), Gaps = 66/261 (25%) Query: 21 IARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLS-PRFHQLDIDDLQSIRALRDFLRK 79 IA+ L + VV+T R AA ++ + R D+ D + AL +R Sbjct: 49 IAQALSAE-GYSVVITGRRPDVLDAAAGEIGGRTGNIVRAVVCDVGDPDQVAALFAAVRA 107 Query: 80 EYGGLNVLVNNAAV-AFKSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIMK----PHGR 134 E+ L++LVNNA + + N +MK GR Sbjct: 108 EFARLDLLVNNAGSNVPPVPLEEVTFEQWNGIVAANLTGAFLCTQHAFRMMKAQTPRGGR 167 Query: 135 VVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPY 194 ++N S+ N ++PY Sbjct: 168 IINNGSISAQTPRPN-----------------------------------------SAPY 186 Query: 195 GVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRT----------- 243 +K +T L++ A + I G TDM + S Sbjct: 187 TATKHAITGLTKSTALD----GRMHDIACGQIDIGNAATDMTARMSTGVLQANGEVAAEP 242 Query: 244 ---VEEGAETPVYLALLPPDA 261 +E AE VY+A LP A Sbjct: 243 TIPIEHIAEAVVYMASLPLSA 263 >2X9N-A nrPDB Length = 288 Score = 96.8 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 40/227 (17%), Positives = 81/227 (35%), Gaps = 32/227 (14%) Query: 8 ALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLS-PRFHQLDIDD 66 A+VTGA + IG AIA +L + V+ + +L E + Q D+ + Sbjct: 26 AVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVCQADLTN 85 Query: 67 ----LQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 S + + + +G +VLVNNA+ + + E + + Sbjct: 86 SNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTP---LVQGDHEDNSNG-----KTVE 137 Query: 123 NELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNE 182 ++ + + +++ + ++ + + T + +V+L V Sbjct: 138 TQVAEL-------IGTNAIAPFLLTMSFAQRQKGTNPNCTSSNLSIVNLCDAMV------ 184 Query: 183 VHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPG 229 ++ S Y + K + L++ A L I VN PG Sbjct: 185 --DQPCMAFSLYNMGKHALVGLTQSAALELAPY----GIRVNGVAPG 225 >3U4C-A nrPDB Length = 281 Score = 96.0 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 49/274 (17%), Positives = 86/274 (31%), Gaps = 70/274 (25%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 R A V GA++GIG AIA +L Q +V+ +R++ ++ + + A+ L Sbjct: 21 MSKRTAFVMGASQGIGKAIALKLADQHFS-LVINSRNLDNIESVKEDILAKHPEASVIVL 79 Query: 63 --DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFD----IKAEMTLKTNFF 116 D+ D + + + + G L+VL+NN P FD T Sbjct: 80 AGDMSDQHTRAGIFQKIESQCGRLDVLINN----IPGGAPDTFDNCNIEDMTATFTQKTV 135 Query: 117 ATRNMCNELLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKK 174 A + +MK + GR++NI + L + + Sbjct: 136 AYIDAIKRASSLMKQNEFGRIINI--VGNLWKEPGANMFTNSMMN--------------- 178 Query: 175 FVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD 234 + S+ ++ +L I VN PG + TD Sbjct: 179 ------------------------AALINASKNISIQLAPH----NITVNCLNPGFIATD 210 Query: 235 ---------MDGKDSIRTVEE---GAETPVYLAL 256 M + E + P+ Sbjct: 211 RYHQFVENVMKKNSISKQKAEEQIASGIPMKRVG 244 >1SNY-A nrPDB Length = 267 Score = 94.5 bits (233), Expect = 5e-20, Method: Composition-based stats. Identities = 54/270 (20%), Positives = 94/270 (34%), Gaps = 62/270 (22%) Query: 2 SSCSRVALVTGANRGIGLAIARELCR--QFSGDVVLTARDVARGQAAVQQLQAEGLSPRF 59 S + + L+TG NRG+GL + + L Q + T R+ + + ++ L + Sbjct: 19 SHMNSI-LITGCNRGLGLGLVKALLNLPQPPQHLFTTCRNREQAKE-LEDLAKNHSNIHI 76 Query: 60 HQLDIDDLQSIRALRDFL--RKEYGGLNVLVNNAAVAFKSDDPMPFD-IKAEMTLKTNFF 116 ++D+ + + L + + GLNVL NNA +A KS + TL+TN Sbjct: 77 LEIDLRNFDAYDKLVADIEGVTKDQGLNVLFNNAGIAPKSARITAVRSQELLDTLQTNTV 136 Query: 117 ATRNMCNELLPIMKPHGR-------------VVNISSLQCLRAFENCSEDLQERFHSETL 163 + LP++K + ++N+SS+ Sbjct: 137 VPIMLAKACLPLLKKAAKANESQPMGVGRAAIINMSSILG-------------------- 176 Query: 164 TEGDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILV 223 + Y SK + ++ L+ L +R I+ Sbjct: 177 ------------------SIQGNTDGGMYAYRTSKSALNAATKSLSVDLYPQR----IMC 214 Query: 224 NACCPGPVKTDMDGKDSIRTVEEGAETPVY 253 + PG VKTDM G + V V Sbjct: 215 VSLHPGWVKTDMGGSSAPLDVPTSTGQIVQ 244 >2QHX-A nrPDB Length = 328 Score = 89.8 bits (221), Expect = 1e-18, Method: Composition-based stats. Identities = 40/243 (16%), Positives = 75/243 (30%), Gaps = 43/243 (17%) Query: 7 VALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLS-PRFHQLDID 65 VALVTGA + +G +IA L + + R A A L A + Q D+ Sbjct: 48 VALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLS 107 Query: 66 DLQS-----------------IRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAE 108 ++ + L +G +VLVNNA+ + + + E Sbjct: 108 NVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDEDGHE 167 Query: 109 MTLKTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDL 168 + E + ++ L + + + + Sbjct: 168 PCV---------GDREAME-----------TATADLFGSNAIAPYFLIKAFAHRVAGTPA 207 Query: 169 VD-LMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACC 227 + + + + + + Y ++K + L+R A L +I VN Sbjct: 208 KHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAP----LQIRVNGVG 263 Query: 228 PGP 230 PG Sbjct: 264 PGL 266 >3U9L-A nrPDB Length = 324 Score = 89.8 bits (221), Expect = 1e-18, Method: Composition-based stats. Identities = 27/136 (19%), Positives = 50/136 (36%), Gaps = 4/136 (2%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVV----LTARDVARGQAAVQQLQAEGLS 56 M ++ L+TGA+ G G A L + R+ + +A + + Sbjct: 1 MVMSKKIILITGASSGFGRLTAEALAGAGHRVYASMRDIVGRNASNVEAIAGFARDNDVD 60 Query: 57 PRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFF 116 R +LD+ S+ D + E G ++VL++NA + N Sbjct: 61 LRTLELDVQSQVSVDRAIDQIIGEDGRIDVLIHNAGHMVFGPAEAFTPEQFAELYDINVL 120 Query: 117 ATRNMCNELLPIMKPH 132 +T+ + LP M+ Sbjct: 121 STQRVNRAALPHMRRQ 136 >2BFA-A nrPDB Length = 288 Score = 89.5 bits (220), Expect = 2e-18, Method: Composition-based stats. Identities = 40/243 (16%), Positives = 75/243 (30%), Gaps = 43/243 (17%) Query: 7 VALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLS-PRFHQLDID 65 VALVTGA + +G +IA L + + R A A L A + Q D+ Sbjct: 8 VALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLS 67 Query: 66 DLQS-----------------IRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAE 108 ++ + L +G +VLVNNA+ + + + E Sbjct: 68 NVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDEDGHE 127 Query: 109 MTLKTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDL 168 + E + ++ L + + + + Sbjct: 128 PCV---------GDREAME-----------TATADLFGSNAIAPYFLIKAFAHRVAGTPA 167 Query: 169 VD-LMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACC 227 + + + + + + Y ++K + L+R A L +I VN Sbjct: 168 KHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAP----LQIRVNGVG 223 Query: 228 PGP 230 PG Sbjct: 224 PGL 226 >2BGM-A nrPDB Length = 278 Score = 88.3 bits (217), Expect = 3e-18, Method: Composition-based stats. Identities = 39/238 (16%), Positives = 68/238 (28%), Gaps = 52/238 (21%) Query: 24 ELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGG 83 +L ++ VV+ GQ + + + F D+ + +R L D ++G Sbjct: 34 KLFVRYGAKVVIADIADDHGQKVCNNIGSPDV-ISFVHCDVTKDEDVRNLVDTTIAKHGK 92 Query: 84 LNVLVNNAAVAFKSD--DPMPFDIKAEMTLKTNFFATRNMCNELLPIM--KPHGRVVNIS 139 L+++ N V + + + + N + + +M G +V + Sbjct: 93 LDIMFGNVGVLSTTPYSILEAGNEDFKRVMDINVYGAFLVAKHAARVMIPAKKGSIVFTA 152 Query: 140 SLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKL 199 S+ A E S Y +K Sbjct: 153 SISSFTAGEGVSH----------------------------------------VYTATKH 172 Query: 200 GVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM---DGKDSIRTVEEGAETPVYL 254 V L+ L L E I VN P V + + VEE A L Sbjct: 173 AVLGLTTSLCTELGEY----GIRVNCVSPYIVASPLLTDVFGVDSSRVEELAHQAANL 226 >2AG5-A nrPDB Length = 246 Score = 86.8 bits (213), Expect = 9e-18, Method: Composition-based stats. Identities = 39/241 (16%), Positives = 69/241 (28%), Gaps = 64/241 (26%) Query: 19 LAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLR 78 LA ARE V+ T + ++ Q + + LD+ + I + + Sbjct: 24 LAFARE-----GAKVIATDINESKLQELEKY-----PGIQTRVLDVTKKKQIDQFANEVE 73 Query: 79 KEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIM--KPHGRVV 136 L+VL N A + + ++ N + M LP M + G ++ Sbjct: 74 ----RLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLPKMLAQKSGNII 129 Query: 137 NISSLQ-CLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPYG 195 N+SS+ ++ N + Sbjct: 130 NMSSVASSVKGVVNRCVYSTTKAA------------------------------------ 153 Query: 196 VSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD-MDGKDSIR-TVEEGAETPVY 253 V L++ +A I N CPG V T + + R EE + Sbjct: 154 -----VIGLTKSVAADF----IQQGIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLK 204 Query: 254 L 254 Sbjct: 205 R 205 >4HBG-A nrPDB Length = 286 Score = 84.8 bits (208), Expect = 3e-17, Method: Composition-based stats. Identities = 52/284 (18%), Positives = 89/284 (31%), Gaps = 88/284 (30%) Query: 7 VALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID- 65 VA+VTGA RGIG AI ++L ++ ++L + + + A+ + Q + Q I Sbjct: 6 VAIVTGATRGIGKAICQKLFQKGLSCIILGSTKESIERTAIDRGQLQSGLSYQRQCAIAI 65 Query: 66 ---------DLQSIRA---------LRDFLRKEYGG------------LNVLVNNAAVAF 95 D +S L+ + +N+L+N A + Sbjct: 66 DFKKWPHWLDYESYDGIEYFKDRPPLKQKYSTLFDPCNKWSNNERRYYVNLLINCAGLTQ 125 Query: 96 KSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIMKPHGR-------------VVNISSLQ 142 +S + + + NF + M N + M R +VNISS+ Sbjct: 126 ESLSVRTTASQIQDIMNVNFMSPVTMTNICIKYMMKSQRRWPELSGQSARPTIVNISSIL 185 Query: 143 CLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVT 202 + S Y SK ++ Sbjct: 186 HSGKMKVPGT---------------------------------------SVYSASKAALS 206 Query: 203 VLSRILARRLDEKRKADRILVNACCPGPVK-TDMDGKDSIRTVE 245 + +LA ++ + I PG VK TDM + E Sbjct: 207 RFTEVLAAEMEPR----NIRCFTISPGLVKGTDMIQNLPVEAKE 246 >1P33-A nrPDB Length = 289 Score = 84.8 bits (208), Expect = 3e-17, Method: Composition-based stats. Identities = 44/253 (17%), Positives = 75/253 (29%), Gaps = 53/253 (20%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLS-PRFH 60 S + VALVTGA + +G +IA L + + R A L A + Sbjct: 4 SPTAPVALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAADASTLAATLNARRPNSAITV 63 Query: 61 QLDIDDLQS-----------------IRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPF 103 Q D+ ++ + AL D +G +VLVNNA Sbjct: 64 QADLSNVATASFSETDGSVPVTLFSRCSALVDACYMHWGRCDVLVNNA------------ 111 Query: 104 DIKAEMTLKTNFFATRNMCNELLPIMKPHGRVV------NISSLQCLRAFENCSEDLQER 157 ++ L G V +++ + L + Sbjct: 112 -------------SSFYPTPLLRKDAGEGGSSVGDKESLEVAAADLFGSNAIAPYFLIKA 158 Query: 158 FHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRK 217 F + + + + + + Y ++K + L+R A L Sbjct: 159 FAQRVADTRAEQRGTSYSIVNMVDAMTSQPLLGYTMYTMAKEALEGLTRSAALELAS--- 215 Query: 218 ADRILVNACCPGP 230 +I VN PG Sbjct: 216 -LQIRVNGVSPGL 227 >2YW9-A nrPDB Length = 261 Score = 83.3 bits (204), Expect = 1e-16, Method: Composition-based stats. Identities = 43/239 (17%), Positives = 84/239 (35%), Gaps = 57/239 (23%) Query: 3 SCSRVALVTGAN--RGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 + ALV G R +G AIA +L ++ +V L+ + R + ++L Sbjct: 6 LSGKKALVMGVTNQRSLGFAIAAKL-KEAGAEVALSYQ-AERLRPEAEKLAEALGGALLF 63 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMP------FDIKAEMTLKTN 114 + D+ + + AL +++ +GGL+ LV A+AF + M + L+ + Sbjct: 64 RADVTQDEELDALFAGVKEAFGGLDYLV--HAIAFAPREAMEGRYIDTRRQDWLLALEVS 121 Query: 115 FFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKK 174 ++ + P+++ G +V ++ + + Sbjct: 122 AYSLVAVARRAEPLLREGGGIVTLTYYASEKVVPKYNVM--------------------- 160 Query: 175 FVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKT 233 ++K + R LA L K + VNA GPV+T Sbjct: 161 --------------------AIAKAALEASVRYLAYELGPK----GVRVNAISAGPVRT 195 >3E9N-A nrPDB Length = 245 Score = 82.9 bits (203), Expect = 1e-16, Method: Composition-based stats. Identities = 45/236 (19%), Positives = 77/236 (32%), Gaps = 54/236 (22%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 MS ++A+VTGA G+G+ I ++L R V R+ A + E + Sbjct: 1 MSLKKKIAVVTGATGGMGIEIVKDLSRDH--IVYALGRNPEHLAALAEIEGVEPIESDIV 58 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 + ++ + + L K ++ LV+ AAVA + + L N Sbjct: 59 K-EVLEEGGVDKL-----KNLDHVDTLVHAAAVARDTTIEAGSVAEWHAHLDLNVIVPAE 112 Query: 121 MCNELLPIMK-PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 + +LLP ++ G V+ I+S Sbjct: 113 LSRQLLPALRAASGCVIYINSGAGNGPHP------------------------------- 141 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 N+ Y SK + L+ + + I V+ PGP T M Sbjct: 142 ----------GNTIYAASKHALRGLADAFRKE----EANNGIRVSTVSPGPTNTPM 183 >1B15-A nrPDB Length = 254 Score = 82.9 bits (203), Expect = 1e-16, Method: Composition-based stats. Identities = 41/241 (17%), Positives = 72/241 (29%), Gaps = 59/241 (24%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M ++ + A GIGL +REL ++ + V+ R A + ++ FH Sbjct: 1 MDLTNKNVIFVAALGGIGLDTSRELVKRNLKNFVILDRVENPTALAELKAINPKVNITFH 60 Query: 61 QLDIDDL-QSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATR 119 D+ + L + + +++L+N A + D + E T+ NF Sbjct: 61 TYDVTVPVAESKKLLKKIFDQLKTVDILINGAGI--------LDDHQIERTIAINFTGLV 112 Query: 120 NMCNELL-----PIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKK 174 N +L P G + NI S+ A Sbjct: 113 NTTTAILDFWDKRKGGPGGIIANICSVTGFNAIHQVPVY--------------------- 151 Query: 175 FVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD 234 SK V + LA+ L + + PG +T Sbjct: 152 --------------------SASKAAVVSFTNSLAK-LAP---ITGVTAYSINPGITRTP 187 Query: 235 M 235 + Sbjct: 188 L 188 >3PPI-A nrPDB Length = 281 Score = 82.5 bits (202), Expect = 2e-16, Method: Composition-based stats. Identities = 52/266 (19%), Positives = 78/266 (29%), Gaps = 49/266 (18%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 A+V+G G+G A R L VV+ +G+A +L G F Sbjct: 27 QFEGASAIVSGGAGGLGEATVRRLHAD-GLGVVIADLAAEKGKALADEL---GNRAEFVS 82 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKS-----DDPMPFDIK-AEMTLKTNF 115 ++ S+ A + + G L V + D P D+ T+ Sbjct: 83 TNVTSEDSVLAAIEAA-NQLGRLRYAVVAHGGFGVAQRIVQRDGSPADMGGFTKTIDLYL 141 Query: 116 FATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKF 175 T N+ + +S+ EN S EG + Sbjct: 142 NGTYNVARLVA------------ASIAAAEPRENGERGALVLTASIAGYEGQI------- 182 Query: 176 VEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235 + Y +K GV L+ AR L I VN PG +KT + Sbjct: 183 --------------GQTAYAAAKAGVIGLTIAAARDLSSA----GIRVNTIAPGTMKTPI 224 Query: 236 DGKDSIRTVE-EGAETPVYLALLPPD 260 + A P L PD Sbjct: 225 MESVGEEALAKFAANIPFPKRLGTPD 250 >4GKB-A nrPDB Length = 258 Score = 81.4 bits (199), Expect = 4e-16, Method: Composition-based stats. Identities = 55/277 (19%), Positives = 85/277 (30%), Gaps = 56/277 (20%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 ++ +V +VTG GIG AI+ L + + VV AR G A + L + Sbjct: 3 LNLQDKVVIVTGGASGIGGAISMRLAEERAIPVVF-ARHAPDG-AFLDALAQRQPRATYL 60 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 +++ D R +G L+ LVNNA V +L+ N Sbjct: 61 PVELQDDAQCRDAVAQTIATFGRLDGLVNNAGV-NDGIGLDAGRDAFVASLERNLIHYYA 119 Query: 121 MCNELLPIMKP-HGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 M + +P +K G +VNISS + N S + LT Sbjct: 120 MAHYCVPHLKATRGAIVNISSKTAVTGQGNTSGYCASKGAQLALT--------------- 164 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM---- 235 R + + VNA P V T + Sbjct: 165 ------------------------------REWAVALREHGVRVNAVIPAEVMTPLYRNW 194 Query: 236 --DGKDSIRTVEE-GAETPVYLALLPPDATEPQGQLV 269 +D + E A+ P+ PD + Sbjct: 195 IATFEDPEAKLAEIAAKVPLGRRFTTPDEIADTAVFL 231 >4CR6-A nrPDB Length = 271 Score = 80.6 bits (197), Expect = 8e-16, Method: Composition-based stats. Identities = 49/241 (20%), Positives = 73/241 (30%), Gaps = 64/241 (26%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 + A+VTGA GIG A R+ + V + + A + + G Sbjct: 13 LAGKAAIVTGAAGGIGRATVEAYLREGASVVAM----DLAPRLAATRYEEPG--AIPIAC 66 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFK---SDDPMPFDIKAEMTLKTNFFATR 119 D+ D +I A GGL++LV A A K + D + + N T Sbjct: 67 DLADRAAIDAAMADAVARLGGLDILV--AGGALKGGTGNFLDLSDADWDRYVDVNMTGTF 124 Query: 120 NMCNELLPIMKPHG--------RVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDL 171 C M G R++ I S+ A + + + Sbjct: 125 LTCRAGARAMVAAGAGKDGRSARIITIGSVNSFMAEPEAAAYVAAKG------------- 171 Query: 172 MKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPV 231 GV +L+R +A L ILVN PGPV Sbjct: 172 ----------------------------GVAMLTRAMAVDLARH----GILVNMIAPGPV 199 Query: 232 K 232 Sbjct: 200 D 200 >1MG5-A nrPDB Length = 255 Score = 77.9 bits (190), Expect = 5e-15, Method: Composition-based stats. Identities = 40/244 (16%), Positives = 73/244 (29%), Gaps = 59/244 (24%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 + ++ + GIGL ++EL ++ ++V+ R A + ++ F+ Sbjct: 2 FTLTNKNVIFVAGLGGIGLDTSKELLKRDLKNLVILDRIENPAAIAELKAINPKVTVTFY 61 Query: 61 QLDIDDL-QSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATR 119 D+ L + + ++VL+N A + D + E T+ N+ Sbjct: 62 PYDVTVPIAETTKLLKTIFAQLKTVDVLINGAGI--------LDDHQIERTIAVNYTGLV 113 Query: 120 NMCNELL-----PIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKK 174 N +L P G + NI S+ A Sbjct: 114 NTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVPV---------------------- 151 Query: 175 FVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD 234 Y +K V + LA+ L VN PG +T Sbjct: 152 -------------------YSGTKAAVVNFTSSLAK-LAPITGVTAYTVN---PGITRTT 188 Query: 235 MDGK 238 + K Sbjct: 189 LVHK 192 >5WQO-A nrPDB Length = 234 Score = 76.0 bits (185), Expect = 2e-14, Method: Composition-based stats. Identities = 48/243 (19%), Positives = 75/243 (30%), Gaps = 47/243 (19%) Query: 8 ALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDL 67 L+ GA+RGIGL +A Q V AR + G + D++ Sbjct: 9 VLIVGASRGIGLGLADAFL-QRGAQVFAVARRPQGSPGLQALAERAGERLQAVTGDLNQH 67 Query: 68 QSIRALRDFLRKEYGGLNVLVNNAAVAFK-SDDPMPFDIKAEMTLK-TNFFATRNMCNEL 125 + + L + ++ L+ NA + D D + L TN A + L Sbjct: 68 DCAERIGEMLGER--RIDRLIVNAGIYGPQQQDVAEIDAEQTAQLFLTNAIAPLRLARAL 125 Query: 126 LPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHE 185 + G V +SS A + Sbjct: 126 SGRVSRGGVVAFMSSQMASLALGLSATMPL------------------------------ 155 Query: 186 REGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTVE 245 YG SK + L R +E + + PG V+T+M G + +VE Sbjct: 156 --------YGASKAALNSLVRSWEGEFEELPFSLLL----LHPGWVRTEMGGDSAPLSVE 203 Query: 246 EGA 248 E A Sbjct: 204 ESA 206 >2P91-A nrPDB Length = 285 Score = 75.6 bits (184), Expect = 2e-14, Method: Composition-based stats. Identities = 43/238 (18%), Positives = 87/238 (36%), Gaps = 54/238 (22%) Query: 3 SCSRVALVTGAN--RGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 + AL+TG R I IA+ R+ + A + + V+++ S Sbjct: 19 LEGKRALITGVANERSIAYGIAKSFHREGAQLAFTYAT--PKLEKRVREIAKGFGSDLVV 76 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDP----MPFDIKAEMTLKTNFF 116 + D+ + I+ L+ FL + +G L+++V++ A A K + ++ + + + Sbjct: 77 KCDVSLDEDIKNLKKFLEENWGSLDIIVHSIAYAPKEEFKGGVIDTSREGFKIAMDISVY 136 Query: 117 ATRNMCNELLPIMK-PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKF 175 + + ELLP+M+ +G +V +S + + + Sbjct: 137 SLIALTRELLPLMEGRNGAIVTLSYYGAEKVVPHYNVM---------------------- 174 Query: 176 VEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKT 233 G++K + R LA + + +NA GPVKT Sbjct: 175 -------------------GIAKAALESTVRYLAYDIAKHGH----RINAISAGPVKT 209 >5KOI-A nrPDB Length = 293 Score = 74.0 bits (180), Expect = 6e-14, Method: Composition-based stats. Identities = 38/219 (17%), Positives = 76/219 (34%), Gaps = 52/219 (23%) Query: 20 AIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRK 79 IA++L Q + D + V+ L + S D++D+ ++ A+ + + K Sbjct: 45 GIAKQLAAQGAELAFTYQGDALGKR--VKPLAEQVGSDFVLPCDVEDIATVDAVFEEIEK 102 Query: 80 EYGGLNVLVNNAAVAFKSD-----DPMPFDIKAEMTLKTNFFATRNMCNELLPIMKPHGR 134 ++GGL+ LV+ + K++ + T+ + ++ + +MK G Sbjct: 103 KWGGLDFLVHAIGFSDKTELKGRYADVTTRENFSRTMVISAYSFTEVAQRAEKLMKDGGS 162 Query: 135 VVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPY 194 ++ ++ R N + Sbjct: 163 ILTLTYGGSTRTIPNYNVM----------------------------------------- 181 Query: 195 GVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKT 233 GV+K + + R LA + I VNA GPV+T Sbjct: 182 GVAKAALEAMVRYLAADYGPQ----GIRVNAISAGPVRT 216 >1W73-A nrPDB Length = 302 Score = 73.3 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 33/213 (15%), Positives = 63/213 (29%), Gaps = 49/213 (23%) Query: 25 LCRQFSGDVVLTARDVARGQAAVQQLQAE-GLSPRFHQLDIDDLQSIRALRDFLRKEYGG 83 L V+ +R + +A +Q+ ++ G Q D+ D ++ L K G Sbjct: 45 LLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGH 104 Query: 84 LNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIM---KPHGRVVNISS 140 N+++NNAA F S + T + E+ + + ++I++ Sbjct: 105 PNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITT 164 Query: 141 LQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLG 200 + + G Sbjct: 165 IYAETGSGFVVPSASAK-----------------------------------------AG 183 Query: 201 VTVLSRILARRLDEKRKADRILVNACCPGPVKT 233 V +S+ LA + + N PGP+KT Sbjct: 184 VEAMSKSLAAEWGKY----GMRFNVIQPGPIKT 212 >3GRK-A nrPDB Length = 293 Score = 73.3 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 46/249 (18%), Positives = 79/249 (31%), Gaps = 57/249 (22%) Query: 3 SCSRVALVTGA--NRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 + L+ G NR I IA+ R+ ++ T + A + V+ L E + Sbjct: 29 LQGKRGLILGVANNRSIAWGIAKA-AREAGAELAFTYQGDA-LKKRVEPLAEELGAFVAG 86 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPM---PFDIKAEMTLKTNFFA 117 D+ D SI A+ + L K++G L+ LV A+ F D + D T + Sbjct: 87 HCDVADAASIDAVFETLEKKWGKLDFLV--HAIGFSDKDELTGRYIDTSEANFTNTMLIS 144 Query: 118 TRNMC---NELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKK 174 ++ +M G ++ ++ + N + Sbjct: 145 VYSLTAVSRRAEKLMADGGSILTLTYYGAEKVMPNYNVM--------------------- 183 Query: 175 FVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD 234 GV+K + + LA L + I VNA GP+KT Sbjct: 184 --------------------GVAKAALEASVKYLAVDLGPQ----NIRVNAISAGPIKTL 219 Query: 235 MDGKDSIRT 243 Sbjct: 220 AASGIGDFR 228 >4Z3K-A nrPDB Length = 275 Score = 71.4 bits (173), Expect = 4e-13, Method: Composition-based stats. Identities = 55/246 (22%), Positives = 83/246 (33%), Gaps = 64/246 (26%) Query: 7 VALVTGANRGIGLAIARELCRQF--SGDVVLTARDVARGQAAVQQLQAE--GLSPRFHQL 62 V L+TGA+RG G +A L +VL+AR+ + +L AE GL Sbjct: 23 VCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPA 82 Query: 63 DIDDLQSIRALRDFLRKE-----YGGLNVLVNNAA----VAFKSDDPMPFDIK---AEMT 110 D+ ++ L LR+ L +L+NNA V+ D + Sbjct: 83 DLGAEAGLQQLLGALRELPRPKGLQRL-LLINNAGSLGDVSKGFVDLSDSTQVNNYWALN 141 Query: 111 LKTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVD 170 L + T ++ + VVNISSL L+ F+ Sbjct: 142 LTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFK---------------------- 179 Query: 171 LMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGP 230 GW + Y K +L ++LA + V PGP Sbjct: 180 -----------------GW--ALYCAGKAARDMLFQVLALE------EPNVRVLNYAPGP 214 Query: 231 VKTDMD 236 + TDM Sbjct: 215 LDTDMQ 220 >5TF4-A nrPDB Length = 274 Score = 69.8 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 42/245 (17%), Positives = 76/245 (31%), Gaps = 53/245 (21%) Query: 5 SRVALVTG--ANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 + L+ G NR I IA+ ++ T + A + V+ L E Sbjct: 12 GKRGLILGLANNRSIAWGIAKT-ASSAGAELAFTYQGEA-MKKRVEPLAEEVKGFVCGHC 69 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVA----FKSDDPMPFDIKAEMTLKTNFFAT 118 D+ D SI A+ + + K++G L+ LV+ + + MT+ + ++ Sbjct: 70 DVSDSASIDAVFNTIEKKWGKLDFLVHAIGFSDKEELSGRYVDISESNFMMTMNISVYSL 129 Query: 119 RNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 + +M G ++ ++ + N + Sbjct: 130 TALTKRAEKLMSDGGSILTLTYYGAEKVVPNYNVM------------------------- 164 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 GV+K + + LA L K I VNA GP+KT Sbjct: 165 ----------------GVAKAALEASVKYLAVDLGPKH----IRVNAISAGPIKTLAASG 204 Query: 239 DSIRT 243 Sbjct: 205 IGDFR 209 >5TQV-A nrPDB Length = 233 Score = 69.8 bits (169), Expect = 1e-12, Method: Composition-based stats. Identities = 52/243 (21%), Positives = 83/243 (34%), Gaps = 56/243 (23%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 + L+ GA+RG+G R+ R +V+ TARD A++ L+A G H LDI Sbjct: 10 KTVLIVGASRGLGREFVRQYQRD-GWNVIATARD----DASLAALRALG--AHAHALDIT 62 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPF--DIKAEMTLKTNFFATRNMCN 123 + I AL L E L+V V + V + + + + TN + Sbjct: 63 QPEQIAALGWKLDGE--RLDVAVVVSGVYGPRTEGVETIASDDFDTVMHTNVRGPMQLLP 120 Query: 124 ELLPIMK-PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNE 182 LLP+++ G + +SS Sbjct: 121 ILLPLVEDARGVLAVVSSRMG--------------------------------------S 142 Query: 183 VHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIR 242 + E G Y SK + + RI + + + PG V+TDM G + Sbjct: 143 ISEATGTTGWLYRASKAALNDVLRIASLQTRHAACI------SLHPGWVRTDMGGAQAAL 196 Query: 243 TVE 245 Sbjct: 197 DPA 199 >1OAA-A nrPDB Length = 259 Score = 67.9 bits (164), Expect = 5e-12, Method: Composition-based stats. Identities = 39/202 (19%), Positives = 74/202 (36%), Gaps = 17/202 (8%) Query: 7 VALVTGANRGIGLAIARELCR--QFSGDVVLTARDVARGQAAVQQLQAE--GLSPRFHQL 62 V ++TGA+RG G A+A +L R ++++AR + + ++L A+ L Sbjct: 8 VCVLTGASRGFGRALAPQLARLLSPGSVMLVSARSESMLRQLKEELGAQQPDLKVVLAAA 67 Query: 63 DIDDLQSIRALRDFLRKE-----YGGLNVLVNNAAVAFK-------SDDPMPFDIKAEMT 110 D+ ++ L +R+ L +L+NNAA +D + + Sbjct: 68 DLGTEAGVQRLLSAVRELPRPEGLQRL-LLINNAATLGDVSKGFLNVNDLAEVNNYWALN 126 Query: 111 LKTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVD 170 L + T N VVNISSL L+ ++ + + L + + Sbjct: 127 LTSMLCLTSGTLNAFQDSPGLSKTVVNISSLCALQPYKGWGLYCAGKAARDMLYQVLAAE 186 Query: 171 LMKKFVEDTKNEVHEREGWPNS 192 V + + + Sbjct: 187 EPSVRVLSYAPGPLDNDMQQLA 208 >2DKN-A nrPDB Length = 255 Score = 67.9 bits (164), Expect = 5e-12, Method: Composition-based stats. Identities = 54/286 (18%), Positives = 90/286 (31%), Gaps = 66/286 (23%) Query: 7 VALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDD 66 V +TG+ GIG A+ +EL + V+ R A +A D+ Sbjct: 3 VIAITGSASGIGAAL-KELLARAGHTVIGIDRGQADIEA-----------------DLST 44 Query: 67 LQSIRALRDFLRKEYGGL-NVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNEL 125 + GG+ + LV A V + + + N+F + + L Sbjct: 45 PGGRETAVAAVLDRCGGVLDGLVCCAGVGVTAANSGL-------VVAVNYFGVSALLDGL 97 Query: 126 LPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEV 183 + V + S+ + E +V+ M E E+ Sbjct: 98 AEALSRGQQPAAVIVGSIAATQP---------------GAAELPMVEAMLAGDEARAIEL 142 Query: 184 HEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM--DGKDSI 241 E++G + Y SK VT L+R + + +N PG V+T + K Sbjct: 143 AEQQGQTHLAYAGSKYAVTCLARRNVVDWAGR----GVRLNVVAPGAVETPLLQASKADP 198 Query: 242 R-------------TVEEGAETPVYLALLPPDATEPQGQLVHDKVV 274 R E E +A L PQ +H V+ Sbjct: 199 RYGESTRRFVAPLGRGSEPREVAEAIAFL----LGPQASFIHGSVL 240 >4HWK-A nrPDB Length = 288 Score = 67.1 bits (162), Expect = 8e-12, Method: Composition-based stats. Identities = 51/246 (20%), Positives = 80/246 (32%), Gaps = 64/246 (26%) Query: 7 VALVTGANRGIGLAIARELCRQF--SGDVVLTARDVARGQAAVQQLQAE--GLSPRFHQL 62 V L+TGA+RG G +A L +VL+AR+ + +L AE GL Sbjct: 36 VCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPA 95 Query: 63 DIDDLQSIRALRDFLRKE-----YGGLNVLVNNAA----VAFKSDDPMPFDIK---AEMT 110 D+ ++ L LR+ L +L+NNA V+ D + Sbjct: 96 DLGAEAGLQQLLGALRELPRPKGLQRL-LLINNAGSLGDVSKGFVDLSDSTQVNNYWALN 154 Query: 111 LKTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVD 170 L + T ++ + VVNISSL L+ F+ + + + L Sbjct: 155 LTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLF------ 208 Query: 171 LMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGP 230 ++LA + V PGP Sbjct: 209 -----------------------------------QVLALE------EPNVRVLNYAPGP 227 Query: 231 VKTDMD 236 + TDM Sbjct: 228 LDTDMQ 233 >3SLK-A nrPDB Length = 795 Score = 66.3 bits (160), Expect = 1e-11, Method: Composition-based stats. Identities = 31/165 (18%), Positives = 58/165 (35%), Gaps = 9/165 (5%) Query: 7 VALVTGANRGIGLAIARELCRQFS-GDVVLTARD---VARGQAAVQQLQAEGLSPRFHQL 62 LVTG +G +AR L + ++VL +R + V QL A G Sbjct: 532 TVLVTGGTGALGAEVARHLVIERGVRNLVLVSRRGPAASGAAELVAQLTAYGAEVSLQAC 591 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 D+ D +++ + + E+ L +V+ A V + + L+ RN+ Sbjct: 592 DVADRETLAKVLASIPDEH-PLTAVVHAAGVLDDGVSESLTVERLDQVLRPKVDGARNLL 650 Query: 123 NELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGD 167 + P + +V SS+ + + L + Sbjct: 651 ELIDPDVA----LVLFSSVSGVLGSGGQGNYAAANSFLDALAQQR 691 >5I9N-A nrPDB Length = 276 Score = 65.2 bits (157), Expect = 3e-11, Method: Composition-based stats. Identities = 46/238 (19%), Positives = 78/238 (32%), Gaps = 54/238 (22%) Query: 3 SCSRVALVTG--ANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 + L+TG +NR I IA+ R+ + D R + + + AE S Sbjct: 4 LDGKRILLTGLLSNRSIAYGIAKACKREGAELAFTYVGD--RFKDRITEFAAEFGSELVF 61 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPF-----DIKAEMTLKTNF 115 D+ D I AL L+ + L+ LV++ A + F + + Sbjct: 62 PCDVADDAQIDALFASLKTHWDSLDGLVHSIGFAPREAIAGDFLDGLTRENFRIAHDISA 121 Query: 116 FATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKF 175 ++ + LP++ ++ +S L RA N + Sbjct: 122 YSFPALAKAALPMLSDDASLLTLSYLGAERAIPNYNTM---------------------- 159 Query: 176 VEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKT 233 G++K + R LA L K + VNA GP+KT Sbjct: 160 -------------------GLAKAALEASVRYLAVSLGAK----GVRVNAISAGPIKT 194 >5YCX-A nrPDB Length = 266 Score = 63.6 bits (153), Expect = 8e-11, Method: Composition-based stats. Identities = 43/245 (17%), Positives = 77/245 (31%), Gaps = 67/245 (27%) Query: 3 SCSRVALVTGAN--RGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQA--EGLSPR 58 + +V G R I IAR L + + A R + V++L EG Sbjct: 6 LQGKTFVVMGVANQRSIAWGIARSLHNAGAKLIFTYAG--ERLERNVRELADTLEGQESL 63 Query: 59 FHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLK------ 112 D+ + + + A + +++E G ++ VA D+K E Sbjct: 64 VLPCDVTNDEELTACFETIKQEVGTIH------GVAHCIAFANRDDLKGEFVDTSRDGFL 117 Query: 113 ----TNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDL 168 + F+ + E +M G ++ ++ L R +N + Sbjct: 118 LAQNISAFSLTAVAREAKKVMTEGGNILTLTYLGGERVVKNYNVM--------------- 162 Query: 169 VDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCP 228 GV+K + + LA L + I VNA Sbjct: 163 --------------------------GVAKASLEASVKYLANDLGQH----GIRVNAISA 192 Query: 229 GPVKT 233 GP++T Sbjct: 193 GPIRT 197 >4M89-A nrPDB Length = 261 Score = 61.7 bits (148), Expect = 3e-10, Method: Composition-based stats. Identities = 41/233 (17%), Positives = 80/233 (34%), Gaps = 17/233 (7%) Query: 3 SCSRVALVTG--ANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 + L+TG + R I IA+ CR+ ++ T V + + V+++ AE S Sbjct: 4 LQGKKILITGMISERSIAYGIAKA-CREQGAELAFTYV-VDKLEERVRKMAAELDSELVF 61 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPF-----DIKAEMTLKTNF 115 + D+ I + L K + GL+ LV++ A K F + + Sbjct: 62 RCDVASDDEINQVFADLGKHWDGLDGLVHSIGFAPKEALSGDFLDSISREAFNTAHEISA 121 Query: 116 FATRNMCNELLPIMKPHGR-VVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKK 174 ++ + P+M+ +V +S L +RA N + + E L K+ Sbjct: 122 YSLPALAKAARPMMRGRNSAIVALSYLGAVRAIPNYNVMGMAKASLEAGIRFTAACLGKE 181 Query: 175 FVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACC 227 + + P S G+ ++L + + Sbjct: 182 GI-----RCNGISAGPIKTLAAS--GIADFGKLLGHVAAHNPLRRNVTIEEVG 227 >3K2E-A nrPDB Length = 296 Score = 61.3 bits (147), Expect = 4e-10, Method: Composition-based stats. Identities = 43/243 (17%), Positives = 85/243 (34%), Gaps = 61/243 (25%) Query: 1 MSSCSRVALVTGAN--RGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPR 58 M + ++ G + + IA+ +C Q +V LT + ++ G+ Sbjct: 26 MLMEGKKGVIIGVANDKSLAWGIAKAVCAQ-GAEVALTYLSETFKKRVDPLAESLGVK-L 83 Query: 59 FHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFAT 118 D+ D +S+ + L +E+G L+ +V AVAF + + + +L NF + Sbjct: 84 TVPCDVSDAESVDNMFKVLAEEWGSLDFVV--HAVAFSDKNELKGRYV-DTSL-GNFLTS 139 Query: 119 RNMC--------NELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVD 170 ++ ++ P+M G ++ +S + + + Sbjct: 140 MHISCYSFTYIASKAEPLMTNGGSILTLSYYGAEKVVPHYNVM----------------- 182 Query: 171 LMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGP 230 GV K + + LA L ++ +I VNA GP Sbjct: 183 ------------------------GVCKAALEASVKYLAVDLGKQ----QIRVNAISAGP 214 Query: 231 VKT 233 V+T Sbjct: 215 VRT 217 >3OIG-A nrPDB Length = 266 Score = 61.0 bits (146), Expect = 6e-10, Method: Composition-based stats. Identities = 48/292 (16%), Positives = 87/292 (29%), Gaps = 78/292 (26%) Query: 1 MSSCSRVALVTGAN--RGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQA--EGLS 56 S R +V G R I IAR L + + A R + +V +L + Sbjct: 3 FSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAG--ERLEKSVHELAGTLDRND 60 Query: 57 PRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFF 116 D+ + I ++++ G ++ +A ++ E L TN Sbjct: 61 SIILPCDVTNDAEIETCFASIKEQVGVIH------GIAHCIAFANKEELVGEY-LNTNRD 113 Query: 117 ATR-----------NMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTE 165 + P+M G +V ++ L N + Sbjct: 114 GFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNVM------------ 161 Query: 166 GDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNA 225 GV+K + + LA L + + I VN+ Sbjct: 162 -----------------------------GVAKASLDASVKYLAADLGK----ENIRVNS 188 Query: 226 CCPGPVKTDMDGK------DSIRTVEEGAETPVYLALLPPDATEPQGQLVHD 271 GP++T + K ++ +EE A P+ P + + L D Sbjct: 189 ISAGPIRT-LSAKGISDFNSILKDIEERA--PLRRTTTPEEVGDTAAFLFSD 237 >4NR0-A nrPDB Length = 273 Score = 60.2 bits (144), Expect = 9e-10, Method: Composition-based stats. Identities = 38/234 (16%), Positives = 74/234 (31%), Gaps = 17/234 (7%) Query: 3 SCSRVALVTGANR--GIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSP-RF 59 + AL+ G I IA + R+ + D RG+ + G P Sbjct: 4 LTGKRALIVGVASKLSIASGIAAAMHREGAELAFTYQNDKLRGR-VEEFASGWGSRPELC 62 Query: 60 HQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPF-----DIKAEMTLKTN 114 D+ D I A+ L K + GL+++V++ A F + + Sbjct: 63 FPCDVADDSQIEAVFAALGKHWDGLDIIVHSVGFAPGDQLDGDFTAVTTREGFRIAHDIS 122 Query: 115 FFATRNMCNELLPIMK-PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMK 173 ++ + +MK +G ++ +S L R N + + E V + Sbjct: 123 AYSFIALAKAGREMMKGRNGSLLTLSYLGAERTMPNYNVMGMAKASLE-----AGVRYLA 177 Query: 174 KFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACC 227 + V+ P S G+ ++LA + + + Sbjct: 178 GSLGAEGTRVNAVSAGPIRTLAAS--GIKSFRKMLAANERQTPLRRNVTIEEVG 229 >1FJH-A nrPDB Length = 257 Score = 58.3 bits (139), Expect = 4e-09, Method: Composition-based stats. Identities = 44/273 (16%), Positives = 79/273 (28%), Gaps = 60/273 (21%) Query: 7 VALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDD 66 + +++G GIG A + L V + RD D+ Sbjct: 3 IIVISGCATGIGAATRKVLEAAGHQIVGIDIRDAE------------------VIADLST 44 Query: 67 LQSIRALRDFLRKE-YGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNEL 125 + + + + G++ LV A + ++ + N+F + + Sbjct: 45 AEGRKQAIADVLAKCSKGMDGLVLCAGLGPQT-------KVLGNVVSVNYFGATELMDAF 97 Query: 126 LPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEV 183 LP +K V ISS+ + + E +V+ Sbjct: 98 LPALKKGHQPAAVVISSVASAHLAFDKNPLALALEAGEEAKARAIVE------------- 144 Query: 184 HEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM--DGKDSI 241 H E N Y SK +T + R+ + +N PG +T + G Sbjct: 145 HAGEQGGNLAYAGSKNALT----VAVRKRAAAWGEAGVRLNTIAPGATETPLLQAGLQDP 200 Query: 242 R-------------TVEEGAETPVYLALLPPDA 261 R E +E +A L A Sbjct: 201 RYGESIAKFVPPMGRRAEPSEMASVIAFLMSPA 233 >5CFZ-A nrPDB Length = 305 Score = 55.6 bits (132), Expect = 2e-08, Method: Composition-based stats. Identities = 47/274 (17%), Positives = 81/274 (29%), Gaps = 47/274 (17%) Query: 3 SCSRVALVTGANR--GIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 + LVTG I IA+ + R+ + D +G+ V++ A+ S Sbjct: 47 LSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGR--VEEFAAQLGSDIVL 104 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 Q D+ + SI + L K + + V ++ F D + D Sbjct: 105 QCDVAEDASIDTMFAELGKVWPKFDGFV--HSIGFAPGDQLDGDY------------VNA 150 Query: 121 MCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 + E I ISS S + L G + + + Sbjct: 151 VTREGFKIAHD------ISS---------YSFVAMAKACRSMLNPGSALLTLSYLGAERA 195 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS 240 + G +K + R +A + + + VNA GP++T Sbjct: 196 IPNYNVMGL-------AKASLEANVRYMANAMGP----EGVRVNAISAGPIRTLAASGIK 244 Query: 241 IRTVEEG---AETPVYLALLPPDATEPQGQLVHD 271 A TP+ + D L D Sbjct: 245 DFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSD 278 >2PD3-A nrPDB Length = 275 Score = 55.6 bits (132), Expect = 3e-08, Method: Composition-based stats. Identities = 40/240 (16%), Positives = 81/240 (33%), Gaps = 59/240 (24%) Query: 3 SCSRVALVTGAN--RGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 + L+ G + I IA+ C + T + + V+ + E SP + Sbjct: 4 LKGKKGLIVGVANNKSIAYGIAQS-CFNQGATLAFTYLN-ESLEKRVRPIAQELNSPYVY 61 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAV----AFKSDDPMPFDIKAEMTLKTNFF 116 +LD+ + ++L + ++K+ G L+ +V++ A A + ++ + + Sbjct: 62 ELDVSKEEHFKSLYNSVKKDLGSLDFIVHSVAFAPKEALEGSLLETSKSAFNTAMEISVY 121 Query: 117 ATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFV 176 + + N L P++ V+ +S L + Sbjct: 122 SLIELTNTLKPLLNNGASVLTLSYLGSTKYM----------------------------- 152 Query: 177 EDTKNEVHEREGWPNSPYGV---SKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKT 233 + Y V +K + R LA L + I VNA GP++T Sbjct: 153 ---------------AHYNVMGLAKAALESAVRYLAVDLGKHH----IRVNALSAGPIRT 193 >4JQC-A nrPDB Length = 282 Score = 55.2 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 47/274 (17%), Positives = 81/274 (29%), Gaps = 47/274 (17%) Query: 3 SCSRVALVTGANR--GIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 + LVTG I IA+ + R+ + D +G+ V++ A+ S Sbjct: 24 LSGKRILVTGVASKLSIAYGIAQAMHREGAELAFTYQNDKLKGR--VEEFAAQLGSDIVL 81 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 Q D+ + SI + L K + + V ++ F D + D Sbjct: 82 QCDVAEDASIDTMFAELGKVWPKFDGFV--HSIGFAPGDQLDGDY------------VNA 127 Query: 121 MCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 + E I ISS S + L G + + + Sbjct: 128 VTREGFKIAHD------ISS---------YSFVAMAKACRSMLNPGSALLTLSYLGAERA 172 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS 240 + G +K + R +A + + + VNA GP++T Sbjct: 173 IPNYNVMGL-------AKASLEANVRYMANAMGP----EGVRVNAISAGPIRTLAASGIK 221 Query: 241 IRTVEEG---AETPVYLALLPPDATEPQGQLVHD 271 A TP+ + D L D Sbjct: 222 DFRKMLAHCEAVTPIRRTVTIEDVGNSAAFLCSD 255 >4ZJU-A nrPDB Length = 275 Score = 55.2 bits (131), Expect = 3e-08, Method: Composition-based stats. Identities = 36/239 (15%), Positives = 70/239 (29%), Gaps = 55/239 (23%) Query: 3 SCSRVALVTGANR--GIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 + L+ G I IA+ L R+ + + + V + + S Sbjct: 14 LAGKRFLIAGVASKLSIAYGIAQALHREGAELAFTYPN--EKLKKRVDEFAEQFGSKLVF 71 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAE-----MTLKTNF 115 D+ I L K + G++ +V++ A F + + + Sbjct: 72 PCDVAVDAEIDNAFAELAKHWDGVDGVVHSIGFAPAHTLDGDFTDVTDRDGFKIAHDISA 131 Query: 116 FATRNMCNELLPIMK-PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKK 174 ++ M P+++ G ++ ++ R N + Sbjct: 132 YSFVAMARAAKPLLQARQGCLLTLTYQGSERVMPNYNVM--------------------- 170 Query: 175 FVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKT 233 G++K + R LA L D I VNA GP++T Sbjct: 171 --------------------GMAKASLEAGVRYLASSLG----VDGIRVNAISAGPIRT 205 >4ALL-A nrPDB Length = 277 Score = 54.4 bits (129), Expect = 5e-08, Method: Composition-based stats. Identities = 37/240 (15%), Positives = 79/240 (32%), Gaps = 53/240 (22%) Query: 1 MSSCSRVALVTGAN--RGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGL-SP 57 ++ ++ ++ G R I +A+ L Q +V T R + + L+ Sbjct: 23 LNLENKTYVIMGIANKRSIAFGVAKVL-DQLGAKLVFTYRKERSRKELEKLLEQLNQPEA 81 Query: 58 RFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVA----FKSDDPMPFDIKAEMTLKT 113 +Q+D+ + + + + K+ G ++ + ++ A A + + Sbjct: 82 HLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDI 141 Query: 114 NFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMK 173 + ++ + +E +M G +V + L A +N + Sbjct: 142 SSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVM-------------------- 181 Query: 174 KFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKT 233 GV+K + + LA L D I VNA GP++T Sbjct: 182 ---------------------GVAKASLEANVKYLALDLGP----DNIRVNAISAGPIRT 216 >4J3F-A nrPDB Length = 280 Score = 53.6 bits (127), Expect = 9e-08, Method: Composition-based stats. Identities = 48/233 (20%), Positives = 79/233 (33%), Gaps = 44/233 (18%) Query: 3 SCSRVALVTG--ANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 + L+TG +N+ I IA+ + R+ + V + + V++L AE Sbjct: 24 LAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTY---VGQFKDRVEKLCAEFNPAAVL 80 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 D+ Q I+ L L K + GL+ +V ++AF D L+ NF Sbjct: 81 PCDVISDQEIKDLFVELGKVWDGLDAIV--HSIAFAPRDQ----------LEGNFIDC-- 126 Query: 121 MCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 + E F + F + ++ + Sbjct: 127 VTRE---------------------GFSIAHDISAYSFAALAKEGRSMMKNRNASMVALT 165 Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKT 233 E+ + GV+K + R A L E D I VNA GP+KT Sbjct: 166 YIGAEKAMPSYNTMGVAKASLEATVRYTALALGE----DGIKVNAVSAGPIKT 214 >3UCF-A nrPDB Length = 223 Score = 51.7 bits (122), Expect = 3e-07, Method: Composition-based stats. Identities = 39/235 (16%), Positives = 66/235 (28%), Gaps = 73/235 (31%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M S V +V G GIG +A++L + +V A Sbjct: 2 MGSDKTVYVVLGGTSGIGAELAKQLESEH--TIVHVASRQTG------------------ 41 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFD-IKAEMTLKTNFFATR 119 LDI D +S+ + + G + L+ A + + + +A+ T F+ Sbjct: 42 -LDISDEKSVYHYFETI----GAFDHLIVTAGSYAPAGKVVDVEVTQAKYAFDTKFWGAV 96 Query: 120 NMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179 +K G + S + + N E Sbjct: 97 LAAKHGARYLKQGGSITLTSGMLSRKVVANTYVKAAINAAIE------------------ 138 Query: 180 KNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD 234 +++LA+ L I VNA PG KT+ Sbjct: 139 -----------------------ATTKVLAKELAP------IRVNAISPGLTKTE 164 >4LIS-A nrPDB Length = 371 Score = 50.6 bits (119), Expect = 7e-07, Method: Composition-based stats. Identities = 33/196 (16%), Positives = 61/196 (31%), Gaps = 15/196 (7%) Query: 8 ALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDL 67 LVTG IG L VV + +A + G F QLD+ D Sbjct: 6 VLVTGGTGYIGSFTTLALLEAGYKVVVADNLYNSSAEALNRIELISGKKAEFAQLDVTD- 64 Query: 68 QSIRALRDFLRKEYGGLNVLVNNAAVAFKSDD-PMPFDIKAEMTLKTNFFATRNMCNELL 126 A D + + + ++ +++ AA+ + P D N + T + ++ Sbjct: 65 ---EAAFDKVFEAHPDIDSVIHFAALKAVGESGEKPLDY-----YHVNVYGTICLLRSMV 116 Query: 127 PIMKPHGRVVNISSLQCLR---AFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEV 183 + +V SS F + + T G+ ++ + D N Sbjct: 117 RHNVTN--IVFSSSATVYGDATRFPDMIPIPEHCPLGPTNPYGNTKFAIELAITDVINAQ 174 Query: 184 HEREGWPNSPYGVSKL 199 + +K Sbjct: 175 RNNAKKAGNETEAAKW 190 >3RFT-A nrPDB Length = 267 Score = 50.2 bits (118), Expect = 9e-07, Method: Composition-based stats. Identities = 25/147 (17%), Positives = 47/147 (31%), Gaps = 27/147 (18%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 + LVTGA +G + L + + L L G + Q D+ Sbjct: 4 KRLLVTGAAGQLGRVMRERLAP-MAEILRLADLSP---------LDPAGPNEECVQCDLA 53 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNEL 125 D ++ A+ G + +V+ ++ + E L+ N N+ Sbjct: 54 DANAVNAMVA-------GCDGIVHLGGISVEKPF--------EQILQGNIIGLYNLYEAA 98 Query: 126 LPIMKPHGRVVNISSLQCLRAFENCSE 152 +P R+V SS + + Sbjct: 99 RAHGQP--RIVFASSNHTIGYYPQTER 123 >3ENK-A nrPDB Length = 341 Score = 48.6 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 23/77 (29%), Positives = 37/77 (48%), Gaps = 3/77 (3%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQA-EGLSPRF 59 MS+ LVTG IG A EL DVV+ V + A+ +++ G +P F Sbjct: 2 MSTKG-TILVTGGAGYIGSHTAVELL-AHGYDVVIADNLVNSKREAIARIEKITGKTPAF 59 Query: 60 HQLDIDDLQSIRALRDF 76 H+ D+ D +++ + D Sbjct: 60 HETDVSDERALARIFDA 76 >4Q9N-A nrPDB Length = 298 Score = 48.6 bits (114), Expect = 3e-06, Method: Composition-based stats. Identities = 36/270 (13%), Positives = 85/270 (31%), Gaps = 82/270 (30%) Query: 1 MSSCSRVALVTGANR--GIGLAIARELCRQFSGDVVLT--------ARDVARGQAAVQQL 50 + ++A + G G G IA+ L + +V T ++ + G+ + Sbjct: 4 IDLTGKIAFIAGIGDDNGYGWGIAKMLAEAGATILVGTWVPIYKIFSQSLELGKFNASRE 63 Query: 51 QAEGLS---PRFHQLDID------------------DLQ--SIRALRDFLRKEYGGLNVL 87 + G + + +D DL ++ + + ++K +G +++L Sbjct: 64 LSNGELLTFAKIYPMDASFDTPEDIPQEILENKRYKDLSGYTVSEVVEQVKKHFGHIDIL 123 Query: 88 V----NNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIMKPHGRVVNISSLQC 143 V N+ +A D L T+ ++ ++ + PIM ++++ L Sbjct: 124 VHSLANSPEIAKPLLDTS--RKGYLAALSTSSYSFISLLSHFGPIMNAGASTISLTYLAS 181 Query: 144 LRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTV 203 +RA + +K + Sbjct: 182 MRAVPGYGGGM----------------------------------------NAAKAALES 201 Query: 204 LSRILARRLDEKRKADRILVNACCPGPVKT 233 +++LA + + VN GP+ + Sbjct: 202 DTKVLAWEAGRRW---GVRVNTISAGPLAS 228 >2O2S-A nrPDB Length = 315 Score = 46.7 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 41/269 (15%), Positives = 74/269 (27%), Gaps = 80/269 (29%) Query: 1 MSSCSRVALVTGA--NRGIGLAIARELCRQFSGDVVLT----------ARDVARGQAAVQ 48 + + A V G + G G AIA+ L + + T + R + Sbjct: 5 IDLRGQTAFVAGVADSHGYGWAIAKHLASAGARVALGTWPPVLGLFQKSLQSGRLDEDRK 64 Query: 49 Q-------------LQAEGLSPRFHQLDIDDLQ--------SIRALRDFLRKEYGGLNVL 87 L A P DI D + +I+ + ++++ G +++L Sbjct: 65 LPDGSLIEFAGVYPLDAAFDKPEDVPQDIKDNKRYAGVDGYTIKEVAVKVKQDLGNIDIL 124 Query: 88 V---NNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIMKPHGRVVNISSLQCL 144 V N + ++ ++ PIM G V +S L Sbjct: 125 VHSLAN-GPEVTKPLLETSRKGYLAASSNSAYSFVSLLQHFGPIMNEGGSAVTLSYLAAE 183 Query: 145 RAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVL 204 R + +K + Sbjct: 184 RVVPGYGGGM----------------------------------------SSAKAALESD 203 Query: 205 SRILARRLDEKRKADRILVNACCPGPVKT 233 +R LA +K + VNA GP+K+ Sbjct: 204 TRTLAWEAGQKY---GVRVNAISAGPLKS 229 >4NK4-A nrPDB Length = 301 Score = 45.9 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 31/242 (12%), Positives = 77/242 (31%), Gaps = 63/242 (26%) Query: 3 SCSRVALVTGANR--GIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSP--- 57 + L+ G I IA+ L + +G++ ++L+ L+ Sbjct: 39 LKGKRGLIMGVANDHSIAWGIAKVLHSAGAQLAFSY-----QGESIGKRLKPLALTVDSD 93 Query: 58 RFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPM---PFDIKAEMTLKTN 114 +++D S+ L + +++ + L+ +V ++AF + + ++ + ++T Sbjct: 94 FMIPCNVEDPSSMDLLFERIKERWETLDFVV--HSIAFSDKNELRGPYYNTSRDNFIQTM 151 Query: 115 FFATRNMC---NELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDL 171 + + +M G ++ ++ +R N + Sbjct: 152 LVSCFSFTEIVRRAAQLMPHGGAMITLTYGGSMRVVPNYNAM------------------ 193 Query: 172 MKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPV 231 +K + ++ LA I +NA GPV Sbjct: 194 -----------------------APAKSALESSTKYLACDYG----GMNIRINAISAGPV 226 Query: 232 KT 233 +T Sbjct: 227 RT 228 >1Z45-A nrPDB Length = 699 Score = 44.4 bits (103), Expect = 5e-05, Method: Composition-based stats. Identities = 35/211 (16%), Positives = 66/211 (31%), Gaps = 24/211 (11%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 S S++ LVTG IG EL VV + + + F+++ Sbjct: 9 STSKIVLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEV 68 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSD-DPMPFDIKAEMTLKTNFFATRNM 121 D+ D + + + ++ +++ A + + +P L T Sbjct: 69 DLCDRKGLEKVFKEY-----KIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVV------ 117 Query: 122 CNELLPIMKPH--GRVVNISSLQCLR---AFENCSEDLQERFHSETLTEGDLVDLMKKFV 176 LL +M+ + + V SS F N +E T G ++ + Sbjct: 118 ---LLELMQQYNVSKFVFSSSATVYGDATRFPNMIPIPEECPLGPTNPYGHTKYAIENIL 174 Query: 177 EDTKNEVHEREGWPNSPY----GVSKLGVTV 203 D N + + Y G G+ Sbjct: 175 NDLYNSDKKSWKFAILRYFNPIGAHPSGLIG 205 >3ORF-A nrPDB Length = 251 Score = 44.4 bits (103), Expect = 5e-05, Method: Composition-based stats. Identities = 17/193 (8%), Positives = 54/193 (27%), Gaps = 14/193 (7%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 S S+ LV G + +G + + + + + R+ + ++ G Sbjct: 19 SHMSKNILVLGGSGALGAEVVKFFKSKSWNTISIDFRENPNADHSFT-IKDSG------- 70 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDD-PMPFDIKAEMTLKTNFFATRN 120 + I+++ + + + ++ V A + F + + N ++ Sbjct: 71 -----EEEIKSVIEKINSKSIKVDTFVCAAGGWSGGNASSDEFLKSVKGMIDMNLYSAFA 125 Query: 121 MCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180 + ++ G V + L + + + + + T Sbjct: 126 SAHIGAKLLNQGGLFVLTGASAALNRTSGMIAYGATKAATHHIIKDLASENGGLPAGSTS 185 Query: 181 NEVHEREGWPNSP 193 + + Sbjct: 186 LGILPVTLDTPTN 198 >1ENP-A nrPDB Length = 312 Score = 44.4 bits (103), Expect = 5e-05, Method: Composition-based stats. Identities = 35/269 (13%), Positives = 76/269 (28%), Gaps = 80/269 (29%) Query: 1 MSSCSRVALVTGANR--GIGLAIARELCRQFSGDVVLTARDVARGQAAVQQ--------- 49 + + A + G G G A+A+ L + +V T + Sbjct: 14 IDLRGKRAFIAGIADDNGYGWAVAKSLAAAGAEILVGTWVPALNIFETSLRRGKFDQSRV 73 Query: 50 --------------LQAEGLSPRFHQLDI--------DDLQSIRALRDFLRKEYGGLNVL 87 L A +P D+ +++ + +R+++G +++L Sbjct: 74 LPDGSLMEIKKVYPLDAVFDNPEDVPEDVKANKRYAGSSNWTVQEAAECVRQDFGSIDIL 133 Query: 88 V---NNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIMKPHGRVVNISSLQCL 144 V N + + ++ ++ + LPIM P G ++++ + Sbjct: 134 VHSLAN-GPEVSKPLLETSRKGYLAAISASSYSFVSLLSHFLPIMNPGGASISLTYIASE 192 Query: 145 RAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVL 204 R + +K + Sbjct: 193 RIIPGYGGGM----------------------------------------SSAKAALESD 212 Query: 205 SRILARRLDEKRKADRILVNACCPGPVKT 233 +R+LA K+ I VN GP+ + Sbjct: 213 TRVLAFEAGRKQ---NIRVNTISAGPLGS 238 >2NTV-A nrPDB Length = 268 Score = 44.0 bits (102), Expect = 6e-05, Method: Composition-based stats. Identities = 44/271 (16%), Positives = 85/271 (31%), Gaps = 61/271 (22%) Query: 3 SCSRVALVTG--ANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 + LV+G + I IA+ + ++ +VLT D R + + Sbjct: 4 LEGKRILVSGIITDSSIAFHIAK-VAQEAGAQLVLTGFD--RLRLIQRIADRLPDKAPLI 60 Query: 61 QLDIDDLQSIRALRDFLRKEYG---GLNVLVNNAAVAFKSD--DPMPFDIKAEMTLKTNF 115 +LD+ + + + L + + E G L+ +V++ ++ FD E K Sbjct: 61 ELDVQNEEHLATLAERVTAEIGEGNKLDGVVHSIGFMPQTGMGTNQFFDAPYEDVSKGIH 120 Query: 116 FATRN---MCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLM 172 +T + + LL IM G +V Sbjct: 121 ISTYSYASLAKALLLIMNSGGSIV------------------------------------ 144 Query: 173 KKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVK 232 ++ W V+K + ++R +AR + + N GP++ Sbjct: 145 --GMDFDPTRAMPAYNWM----TVAKSALESVNRFVAREAGKY----GVRSNLVAAGPIR 194 Query: 233 TDMDGKDSIRTVEEGAETPVYLALLPPDATE 263 T +I G E + LL + Sbjct: 195 T--LAMSAIVGGAFGEEAGAQMQLLEEGWDQ 223 >4G5H-A nrPDB Length = 363 Score = 44.0 bits (102), Expect = 7e-05, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 30/77 (38%), Gaps = 2/77 (2%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M ++ L+TG G A+ + ++ + +RD + ++ L F+ Sbjct: 21 MGFDDKILLITGGTGSFGNAVMKRFLDSNIKEIRIFSRDEKKQDDIRKKYNNSKLK--FY 78 Query: 61 QLDIDDLQSIRALRDFL 77 D+ D QS+ + Sbjct: 79 IGDVRDSQSVETAMRDV 95 >2PK3-A nrPDB Length = 321 Score = 43.6 bits (101), Expect = 8e-05, Method: Composition-based stats. Identities = 45/227 (19%), Positives = 75/227 (33%), Gaps = 60/227 (26%) Query: 8 ALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDL 67 AL+TG +G +A L Q + +V T+R+ A+ + LDI D Sbjct: 15 ALITGVAGFVGKYLANHLTEQ-NVEVFGTSRNNE----------AKLPNVEMISLDIMDS 63 Query: 68 QSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEM--TLKTNFFATRNMCNEL 125 Q ++ + ++ +Y + + D T TN F T ++ + + Sbjct: 64 QRVKKVISDIKPDY-----------IFHLAAKSSVKDSWLNKKGTFSTNVFGTLHVLDAV 112 Query: 126 LPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHE 185 R++ I S + + + E Sbjct: 113 RDSNLDC-RILTIGS----------------------------SEEYGMILPEESPVSEE 143 Query: 186 REGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRI---LVNACCPG 229 + P SPYGVSK V + LAR+ + D I N PG Sbjct: 144 NQLRPMSPYGVSKASV-GM---LARQYVKAYGMDIIHTRTFNHIGPG 186 >1GY8-A nrPDB Length = 397 Score = 43.2 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 47/284 (16%), Positives = 91/284 (32%), Gaps = 37/284 (13%) Query: 8 ALVTGANRGIGLAIARELCRQFSGDVVLTAR---------DVARGQAAVQQLQA-EGLSP 57 LV G IG R L R + VV+ V + ++LQ +G P Sbjct: 5 VLVCGGAGYIGSHFVRALLRDTNHSVVIVDSLVGTHGKSDHVETRENVARKLQQSDGPKP 64 Query: 58 ----RFHQLDIDDLQSIRALRDFLRKEYGGLNVLV---NNAAVAFKSDDPMPFDIKAEMT 110 R+ L++ D+++ + + +G ++ +V AV DP+ + Sbjct: 65 PWADRYAALEVGDVRN-EDFLNGVFTRHGPIDAVVHMCAFLAVGESVRDPLKY------- 116 Query: 111 LKTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVD 170 N + +L + +++ SS + + + Sbjct: 117 YDNNVVGILRLLQAML--LHKCDKIIF-SSSAAIFGNPTMGSVSTNAEPIDINAKKS--- 170 Query: 171 LMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARR---LDEKRKADRILVNACC 227 + ++K YG+ + + + A + E + L+ Sbjct: 171 -PESPYGESKLIAERMIRDCAEAYGIKGICLRYFNACGAHEDGDIGEHYQGSTHLIPIIL 229 Query: 228 PGPVKTDMDGKDSIRTVEEGAETPVYLALLPPDATEPQGQLVHD 271 G V +D+ D T+ E A T + + D P G V D Sbjct: 230 -GRVMSDI-APDQRLTIHEDASTDKRMPIFGTDYPTPDGTCVRD 271 >1OC2-A nrPDB Length = 348 Score = 43.2 bits (100), Expect = 1e-04, Method: Composition-based stats. Identities = 40/227 (17%), Positives = 61/227 (26%), Gaps = 41/227 (18%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQA-EGLSPRFHQLDI 64 + +VTG IG DV +T D L+A G DI Sbjct: 5 KNIIVTGGAGFIGSNFVH-YVYNNHPDVHVTVLDKLTYAGNKANLEAILGDRVELVVGDI 63 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSD---DPMPFDIKAEMTLKTNFFATRNM 121 D + + L + +V+ AA + + DP PF + TNF T + Sbjct: 64 ADAELVDKLAAKA-------DAIVHYAAESHNDNSLNDPSPF-------IHTNFIGTYTL 109 Query: 122 CNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKN 181 V+ + DL + Sbjct: 110 LEAARKYDIRFHH-VSTDEVYGDLPLRE--------------------DLPGHGEGPGEK 148 Query: 182 EVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCP 228 E P+SPY +K ++ + R K N P Sbjct: 149 FTAETNYNPSSPYSSTKAASDLIVKAWVRSFGVKATISNCS-NNYGP 194 >1R66-A nrPDB Length = 337 Score = 42.8 bits (99), Expect = 1e-04, Method: Composition-based stats. Identities = 50/228 (21%), Positives = 77/228 (33%), Gaps = 55/228 (24%) Query: 9 LVTGANRGIGLAIARELCRQFSGDV------VLTARDVARGQAAVQQLQAEGLSPRFHQL 62 LVTG IG R+L DV VL + A +A + + A+ RF Sbjct: 4 LVTGGAGFIGSHFVRQLLAGAYPDVPADEVIVLDSLTYAGNRANLAPVDADP-RLRFVHG 62 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 DI D L +E G++ +V+ AA + A + +TN T+ + Sbjct: 63 DIRDAG-------LLARELRGVDAIVHFAAESHVDRSI----AGASVFTETNVQGTQTLL 111 Query: 123 NELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNE 182 + GRVV++S+ + + ++ S Sbjct: 112 QCAVDA--GVGRVVHVSTDEVYGSIDSGSW------------------------------ 139 Query: 183 VHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRIL--VNACCP 228 PNSPY SK G +++R R RI N P Sbjct: 140 TESSPLEPNSPYAASKAGSDLVARAYHRTYG---LDVRITRCCNNYGP 184 >4OYR-A nrPDB Length = 289 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 43/271 (15%), Positives = 88/271 (32%), Gaps = 61/271 (22%) Query: 3 SCSRVALVTG--ANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 + LV+G + I IA + ++ +VLT D R + + Sbjct: 25 LDGKRILVSGIITDSSIAFHIA-RVAQEQGAQLVLTGFD--RLRLIQRITDRLPAKAPLL 81 Query: 61 QLDIDDLQSIRALRDFLRKEYG---GLNVLVNNAAVAFKSDDPM--PFDIKAEMT---LK 112 +LD+ + + + +L + + G L+ +V++ ++ + FD + Sbjct: 82 ELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIH 141 Query: 113 TNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLM 172 + ++ +M LLPIM P G +V Sbjct: 142 ISAYSYASMAKALLPIMNPGGSIV------------------------------------ 165 Query: 173 KKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVK 232 ++ + W V+K + ++R +AR + + N GP++ Sbjct: 166 --GMDFDPSRAMPAYNWM----TVAKSALESVNRFVAREAGKY----GVRSNLVAAGPIR 215 Query: 233 TDMDGKDSIRTVEEGAETPVYLALLPPDATE 263 T +I G E + LL + Sbjct: 216 T--LAMSAIVGGALGEEAGAQIQLLEEGWDQ 244 >1I3M-A nrPDB Length = 348 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 36/153 (23%), Positives = 52/153 (33%), Gaps = 29/153 (18%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVL-----TARDVARGQAAVQQLQAE-GLSP 57 + LVTG IG EL VV+ R +++++Q G S Sbjct: 1 MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV 60 Query: 58 RFHQLDIDDLQSIRALRDF----LRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKT 113 F ++DI D +++ L + GL A P D + Sbjct: 61 EFEEMDILDQGALQRLFKKYSFMAVIHFAGL--------KAMGESVQKPLDY-----YRV 107 Query: 114 NFFATRNMCNELLPIMKPHG--RVVNISSLQCL 144 N T +LL IMK HG +V SS Sbjct: 108 NLTGTI----QLLEIMKAHGVKNLVFSSSATVY 136 >2GGS-A nrPDB Length = 273 Score = 42.1 bits (97), Expect = 3e-04, Method: Composition-based stats. Identities = 42/217 (19%), Positives = 83/217 (38%), Gaps = 38/217 (17%) Query: 9 LVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQ 68 L+TGA+ +G+ ++ L + + + +G ++LD+ D Sbjct: 4 LITGASGQLGIELS-RLLSERHEVIKVYNSSEIQG---------------GYKLDLTDFP 47 Query: 69 SIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELLPI 128 L DF+ K+ +V++N AA+ D +I+ E K N A R++ + Sbjct: 48 ---RLEDFIIKK--RPDVIINAAAMT----DVDKCEIEKEKAYKINAEAVRHIVRAG-KV 97 Query: 129 MKPHGRVVNISSLQCLRA----FENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVH 184 + + +V+IS+ ++ ++ + G+ L + + + Sbjct: 98 IDSY--IVHISTDYVFDGEKGNYKEEDIPNPINYYGLSKLLGETFALQDDSLIIRTSGIF 155 Query: 185 EREGWPNSPYGVSKLGVTVL------SRILARRLDEK 215 +G+P Y K G TV S I AR+L Sbjct: 156 RNKGFPIYVYKTLKEGKTVFAFKGYYSPISARKLASA 192 >1BXK-A nrPDB Length = 355 Score = 40.9 bits (94), Expect = 7e-04, Method: Composition-based stats. Identities = 35/226 (15%), Positives = 62/226 (27%), Gaps = 37/226 (16%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 R L+TG IG A+ R + + S VV+ + G A+ F ++DI Sbjct: 2 RKILITGGAGFIGSALVRYIINETSDAVVVVDKLTYAGNLMSLAPVAQSERFAFEKVDIC 61 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAE---MTLKTNFFATRNMC 122 D + + + + D + ++TN T + Sbjct: 62 DRAELARVFTEHQPD------------CVMHLAAESHVDRSIDGPAAFIETNIVGTYTLL 109 Query: 123 NELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNE 182 + +ED + F ++ ++ + + Sbjct: 110 EAARA------------------YWNALTEDKKSAFRFHHISTDEVYGDLHSTDDFFTET 151 Query: 183 VHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCP 228 P+SPY SK L R R N P Sbjct: 152 ---TPYAPSSPYSASKASSDHLVRAWLRTYGLPTLITNCS-NNYGP 193 >1UDA-A nrPDB Length = 338 Score = 40.5 bits (93), Expect = 7e-04, Method: Composition-based stats. Identities = 19/115 (16%), Positives = 42/115 (36%), Gaps = 7/115 (6%) Query: 8 ALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLS-PRFHQLDIDD 66 LVTG + IG +L Q DV++ ++ + ++ G P F + DI + Sbjct: 3 VLVTGGSGYIGSHTCVQLL-QNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 Query: 67 LQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 AL + ++ ++ +++ A + + + + M Sbjct: 62 ----EALMTEILHDH-AIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAM 111 >5K1S-A nrPDB Length = 362 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 19/81 (23%), Positives = 31/81 (38%), Gaps = 4/81 (4%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRF--HQ 61 L+TGA+ G+GL+ + +L R V+ A+ QA + E + R Sbjct: 183 AGETVLITGASGGVGLS-SVQLARLDGARVIAVTSSEAKVQALKEAGADEVIVSRGLDFA 241 Query: 62 LDIDDLQSIRALRDFLRKEYG 82 D+ A D + G Sbjct: 242 SDVRKRTQ-GAGVDVAVEIVG 261 >4J2O-A nrPDB Length = 363 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 32/184 (17%), Positives = 60/184 (32%), Gaps = 17/184 (9%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 +V L+TG G A+ + ++ + +RD + ++ + L F+ D+ Sbjct: 24 KVLLITGGTGSFGNAVLKRFLETDIKEIRIFSRDEKKQDDMRKKYHSAKLK--FYIGDVR 81 Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAV-AFKSDDPMPFDIKAEMTLKTNFFATRNMCNE 124 D SI G++ + + AA+ S + P + KTN T N+ Sbjct: 82 DYNSILNATR-------GVDYIYHAAALKQVPSCEFHPMEAV-----KTNVLGTENVLEA 129 Query: 125 LLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVH 184 + RVV +S+ + + +L L V Sbjct: 130 AIQNHVK--RVVCLSTDKAVYPINAMGISKAMMEKVMVAKSRNLEGLDTVICGTRYGNVM 187 Query: 185 EREG 188 G Sbjct: 188 ASRG 191 >4K28-A nrPDB Length = 269 Score = 39.4 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 29/131 (22%), Positives = 41/131 (31%), Gaps = 19/131 (14%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 + ALV G G+G AIA L + L AR AV +L G Sbjct: 124 AGKRALVIGC-GGVGSAIAYALAEAGIASITLCDPSTARM-GAVCELLGNGFPGLTVSTQ 181 Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAA-VAFKSDDPMPFDIKAEMTLK-TNFFATRNM 121 L+ LV NA+ V + +P TL+ A Sbjct: 182 FSGLEDFD---------------LVANASPVGMGTRAELPLSAALLATLQPDTLVADVVT 226 Query: 122 CNELLPIMKPH 132 E+ P++ Sbjct: 227 SPEITPLLNRA 237 >4J6F-A nrPDB Length = 382 Score = 39.0 bits (89), Expect = 0.002, Method: Composition-based stats. Identities = 18/80 (22%), Positives = 26/80 (32%), Gaps = 1/80 (1%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 LVTGA+ G+G AI +L R + A QA + + Sbjct: 206 AGETVLVTGASGGVGSAI-IQLARARGAVPIAVAGPGKEAAMLDIGAQAVVTRGQGDLAE 264 Query: 64 IDDLQSIRALRDFLRKEYGG 83 + S D + GG Sbjct: 265 AVEAASGGRPIDVVADLVGG 284 >3F4B-A nrPDB Length = 323 Score = 38.6 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 37/258 (14%), Positives = 75/258 (29%), Gaps = 80/258 (31%) Query: 12 GANRGIGLAIARELCRQFSGDVVLT--------ARDVARGQAAVQQLQAEGLSPRFHQLD 63 G + G G IA+EL ++ + +++ G+ + S R LD Sbjct: 16 GDSNGYGWGIAKELSKRNVKVIFGVWPPVYNIFIKNLESGKFDKDMIINNDNSKRMQILD 75 Query: 64 I----------DDLQ---------------SIRALRDFLRKEYGGLNVLV---NNAAVAF 95 + DD+ SI + + + +YG +++LV N Sbjct: 76 VLPLDAGFDNYDDIDEDTKNNKRYNNLKNYSIEEVANLIYNKYGKISMLVHSLAN-GREV 134 Query: 96 KSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQ 155 + + + ++ ++C M G VV+++ + + Sbjct: 135 QKSLLDTSRDGYLDAISKSSYSLISLCKHFCKFMNSGGSVVSLTYQASQKVVPGYGGGM- 193 Query: 156 ERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEK 215 +K + +R+LA L K Sbjct: 194 ---------------------------------------SSAKAALESDTRVLAYYLGRK 214 Query: 216 RKADRILVNACCPGPVKT 233 I +N GP+K+ Sbjct: 215 Y---NIRINTISAGPLKS 229 >2GN9-A nrPDB Length = 344 Score = 38.6 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 24/129 (18%), Positives = 48/129 (37%), Gaps = 20/129 (15%) Query: 3 SCSRVALVTGANRGIGLAIARE-LCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 ++ L+TG G R+ L + +++ +RD + + RF Sbjct: 19 LDNQTILITGGTGSFGKCFVRKVLDTTNAKKIIVYSRDELKQSEMAMEFND--PRMRFFI 76 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAA---VAFKSDDPMPFDIKAEMTLKTNFFAT 118 D+ DL+ + + G+++ ++ AA V +P+ +KTN Sbjct: 77 GDVRDLERLNYALE-------GVDICIHAAALKHVPIAEYNPLE-------CIKTNIMGA 122 Query: 119 RNMCNELLP 127 N+ N L Sbjct: 123 SNVINACLK 131 >2PTG-A nrPDB Length = 319 Score = 38.6 bits (88), Expect = 0.003, Method: Composition-based stats. Identities = 29/247 (11%), Positives = 65/247 (26%), Gaps = 50/247 (20%) Query: 3 SCSRVALVTGA--NRGIGLAIARELCRQFSGDVVLT---------------------ARD 39 + A V G + G G AI + L + +V T Sbjct: 7 LRGKTAFVAGVADSNGYGWAICKLLRAAGARVLVGTWPPVYSIFKKGLESSRFEQDSFYA 66 Query: 40 VARGQAAVQQLQAEGLSPRFHQL-----------DIDDLQS------------IRALRDF 76 + + + F ++ D+ S I + + Sbjct: 67 QEPSSKVAAEAAEKPVDLVFDKIYPLDAVFDTPQDVPPEVSSNKRYAGVGGFTISEVAEA 126 Query: 77 LRKEYGGLNVLV---NNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIMKPHG 133 +R + G +++LV N + ++ ++ ++ LP+MK G Sbjct: 127 VRADVGQIDILVHSLAN-GPEVTKPLLQTSRKGYLAAVSSSSYSFVSLLQHFLPLMKEGG 185 Query: 134 RVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSP 193 + +S + + + + L + N + + Sbjct: 186 SALALSYIASEKVIPGYGGGMSSAKAALESDCRTLAFEAGRARAVRVNCISAGPLKSRAA 245 Query: 194 YGVSKLG 200 + K G Sbjct: 246 SAIGKAG 252 >2NNL-D nrPDB Length = 337 Score = 37.5 bits (85), Expect = 0.007, Method: Composition-based stats. Identities = 50/281 (17%), Positives = 80/281 (28%), Gaps = 62/281 (22%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M S S VTGA+ IG + L + V T RD + L Sbjct: 1 MGSQSETVCVTGASGFIGSWLVMRLL-ERGYTVRATVRDPTNVKKVKHLLDLPKAETHLT 59 Query: 61 --QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFAT 118 + D+ D S + ++ G +V A + P + + T++ Sbjct: 60 LWKADLADEGSFD---EAIKGCTGVFHV-----ATPMDFESKDPENEVIKPTIEGMLGIM 111 Query: 119 RNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178 ++ K R+V SS + E+ E S+ Sbjct: 112 KSCAAA-----KTVRRLVFTSSAGTVNIQEHQLPVYDESCWSDM---------------- 150 Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVN---ACCPGPVKTDM 235 E + Y VSK L+ A + ++ D I + P + + M Sbjct: 151 ---EFCRAKKMTAWMYFVSKT----LAEQAAWKYAKENNIDFITIIPTLVVGP-FIMSSM 202 Query: 236 DGKDSIRTVEEGAETPVYLALLPPDATEPQ------GQLVH 270 + AL P E GQ VH Sbjct: 203 PPS-------------LITALSPITGNEAHYSIIRQGQFVH 230 >6GCS-E nrPDB Length = 375 Score = 37.1 bits (84), Expect = 0.008, Method: Composition-based stats. Identities = 23/109 (21%), Positives = 45/109 (41%), Gaps = 14/109 (12%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEG--LSPRF 59 S A V GAN +G + +L + + VV R + A + L+ G F Sbjct: 50 SRTGYTATVFGANGFLGSYLTAKLAKHGTTVVVPY-----REEMAKRHLKVTGDLGVVNF 104 Query: 60 HQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAE 108 ++D+ +L+SI +++VN +++ + +D+ E Sbjct: 105 LEMDLRNLESIDEAVRHS-------DIVVNLIGREYETKNFNYYDVHVE 146 >4R1T-A nrPDB Length = 337 Score = 37.1 bits (84), Expect = 0.008, Method: Composition-based stats. Identities = 28/154 (18%), Positives = 49/154 (31%), Gaps = 20/154 (12%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAA-VQQLQAEGLSPRFH 60 S +V VTGA I + + L + V T R+ + +++L+ Sbjct: 7 SVSGQVVCVTGAGGFIASWLVKILLEK-GYTVRGTVRNPDDPKNGHLRELEGAKERLTLC 65 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 + D+ D QS+R + P E ++ T+N Sbjct: 66 KADLLDYQSLREAIN----------------GCDGVFHTASPVTDDPEQMVEPAVIGTKN 109 Query: 121 MCNELLPIMKPHGRVVNISSLQCLRAFENCSEDL 154 + N RVV SS+ + N + Sbjct: 110 VINAAAEANVR--RVVFTSSIGAVYMDPNRDPET 141 >1KEU-A nrPDB Length = 361 Score = 37.1 bits (84), Expect = 0.009, Method: Composition-based stats. Identities = 36/228 (15%), Positives = 60/228 (26%), Gaps = 39/228 (17%) Query: 9 LVTGANRGIGLAIARELCRQFSGDVVLTA-RDVARGQAAVQQLQAEGLSPRFHQLDIDDL 67 L+TG IG A+ R + + VV A ++ + F DI D Sbjct: 4 LITGGAGFIGSAVVRHIIKNTQDTVVNIDKLTYAGNLESLSDISESN-RYNFEHADICDS 62 Query: 68 QSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKA--EMTLKTNFFATRNMCNEL 125 I + + + + AV + + ++TN T + Sbjct: 63 AEITRIFEQYQPD-----------AVMHLAAESHVDRSITGPAAFIETNIVGTYALLEVA 111 Query: 126 LPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHE 185 G ED + F ++ ++ + E + Sbjct: 112 RKYWSALG------------------EDKKNNFRFHHISTDEVYGDLPHPDEVENSVTLP 153 Query: 186 -----REGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCP 228 P+SPY SK L R R N P Sbjct: 154 LFTETTAYAPSSPYSASKASSDHLVRAWRRTYGLPTIVTNCS-NNYGP 200 >4R1U-A nrPDB Length = 349 Score = 36.7 bits (83), Expect = 0.010, Method: Composition-based stats. Identities = 31/152 (20%), Positives = 52/152 (34%), Gaps = 26/152 (17%) Query: 6 RVALVTGANRGIGLAIA---RELCRQFSGDVVLTARDVARGQAA-VQQLQAEGLSPRFHQ 61 + VTGA G IA +L + V T R+ + +++L+ H+ Sbjct: 28 QTVCVTGA----GGFIASWLVKLLLERGYTVRGTVRNPEDPKNGHLKELEGARERLTLHK 83 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 +D+ DLQSI+++ P + L+ T+N+ Sbjct: 84 VDLLDLQSIQSVVH----------------GCHGVFHTASPVTDNPDEMLEPAVNGTKNV 127 Query: 122 CNELLPIMKPHGRVVNISSLQCLRAFENCSED 153 RVV SS+ + N S D Sbjct: 128 IIASAEAKVR--RVVFTSSIGTVYMDPNTSRD 157 >4EUF-A nrPDB Length = 418 Score = 35.9 bits (81), Expect = 0.019, Method: Composition-based stats. Identities = 15/96 (15%), Positives = 37/96 (38%), Gaps = 13/96 (13%) Query: 6 RVALVTGANRGIGLA--IARELCRQFSGDVVLTARDVARGQAAVQQ-----------LQA 52 + L+ GA+ G GLA I+ + + ++ A + + Sbjct: 61 KKVLIVGASSGFGLATRISVAFGGPEAHTIGVSYETGATDRRIGTAGWYNNIFFKEFAKK 120 Query: 53 EGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLV 88 +GL + D ++ + +++ E+G +++ V Sbjct: 121 KGLVAKNFIEDAFSNETKDKVIKYIKDEFGKIDLFV 156 >2O2Y-A nrPDB Length = 349 Score = 35.5 bits (80), Expect = 0.023, Method: Composition-based stats. Identities = 25/167 (14%), Positives = 54/167 (32%), Gaps = 47/167 (28%) Query: 70 IRALRDFLRKEYGGLNVLV---NNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELL 126 I + + + ++YG +N+LV NA + D L + ++ ++C + Sbjct: 112 IEDVANLIHQKYGKINMLVHSLANA-KEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFV 170 Query: 127 PIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHER 186 IMKP +++++ + + Sbjct: 171 NIMKPQSSIISLTYHASQKVVPGYGGGM-------------------------------- 198 Query: 187 EGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKT 233 +K + +R+LA L + I +N GP+K+ Sbjct: 199 --------SSAKAALESDTRVLAYHLG---RNYNIRINTISAGPLKS 234 >1RPN-A nrPDB Length = 335 Score = 35.5 bits (80), Expect = 0.024, Method: Composition-based stats. Identities = 19/76 (25%), Positives = 34/76 (44%), Gaps = 1/76 (1%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 S +R ALVTG G +A+ L + L AR + + +++L EG ++ Sbjct: 12 SMTRSALVTGITGQDGAYLAKLLLEKGYRVHGLVARRSSDTRWRLRELGIEG-DIQYEDG 70 Query: 63 DIDDLQSIRALRDFLR 78 D+ D S++ + Sbjct: 71 DMADACSVQRAVIKAQ 86 >3PVZ-A nrPDB Length = 399 Score = 35.5 bits (80), Expect = 0.026, Method: Composition-based stats. Identities = 21/127 (16%), Positives = 45/127 (35%), Gaps = 11/127 (8%) Query: 9 LVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE----GLSPRFHQLDI 64 LV G IG A+ +E+ ++ + + V+ +++ + LDI Sbjct: 39 LVLGGAGSIGQAVTKEIFKRNPQKLHVVDISENNMVELVRDIRSSFGYINGDFQTFALDI 98 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE 124 ++ D K G + ++N +A+ + PF + + N F T + Sbjct: 99 GSIE-----YDAFIKADGQYDYVLNLSALKHVRSEKDPFTLM--RMIDVNVFNTDKTIQQ 151 Query: 125 LLPIMKP 131 + Sbjct: 152 SIDAGAK 158 >2VN8-A nrPDB Length = 375 Score = 35.1 bits (79), Expect = 0.036, Method: Composition-based stats. Identities = 20/120 (16%), Positives = 43/120 (35%), Gaps = 15/120 (12%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 + + L+ GA+ G+G A ++ + + V TA V++L A+ Sbjct: 181 NCTGKRVLILGASGGVG-TFAIQVMKAWDAHV--TAVCSQDASELVRKLGAD-------- 229 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 D+ D +S + K + +++N + ++ P F K + Sbjct: 230 -DVIDYKS--GSVEEQLKSLKPFDFILDNVGGSTETWAP-DFLKKWSGATYVTLVTPFLL 285 >3WMX-A nrPDB Length = 358 Score = 35.1 bits (79), Expect = 0.036, Method: Composition-based stats. Identities = 27/166 (16%), Positives = 50/166 (30%), Gaps = 21/166 (12%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 M + L+ GAN IG +A L ++ V+T+ V G+ Sbjct: 21 MEAGKPKILIVGANGQIGSELALALAERYGRTNVITSDVVPTGRHV---------HLTHE 71 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120 L+ D + + +G V + AA++ + + + + + Sbjct: 72 MLNATDRGE----LATVVERHGITQVYLLAAALSATGEKAPQW--AWNLNMTSLLNVLEL 125 Query: 121 MCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEG 166 L RV SS+ + Q+ T G Sbjct: 126 ARQTGLE------RVFWPSSIAAFGPTTPAGQTPQKTVMEPTTVYG 165 >1YB5-A nrPDB Length = 351 Score = 34.8 bits (78), Expect = 0.039, Method: Composition-based stats. Identities = 31/200 (15%), Positives = 67/200 (33%), Gaps = 41/200 (20%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLD 63 LV GA+ G+GLA A ++ R + ++ TA + +Q G F+ + Sbjct: 170 AGESVLVHGASGGVGLA-ACQIARAYGLKILGTAGTEEGQKIVLQ----NGAHEVFNHRE 224 Query: 64 IDDLQSIRALRDFLRKEYG--GLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 + D ++K G G+++++ ++ A + L + Sbjct: 225 V-------NYIDKIKKYVGEKGIDIII---------------EMLANVNLSKDLS----- 257 Query: 122 CNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE-DTK 180 ++ GRV+ + S + + + TL + + Sbjct: 258 ------LLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAG 311 Query: 181 NEVHEREGWPNSPYGVSKLG 200 E+ + S Y + K+ Sbjct: 312 MEIGWLKPVIGSQYPLEKVA 331 >4DGK-A nrPDB Length = 501 Score = 34.8 bits (78), Expect = 0.040, Method: Composition-based stats. Identities = 21/72 (29%), Positives = 30/72 (41%), Gaps = 3/72 (4%) Query: 10 VTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQS 69 V GA G GLA+A L ++L RD G+A V + +G + I D + Sbjct: 6 VIGAGFG-GLALAIRLQAAGIPVLLLEQRDKPGGRAYV--YEDQGFTFDAGPTVITDPSA 62 Query: 70 IRALRDFLRKEY 81 I L K+ Sbjct: 63 IEELFALAGKQL 74 >6BWL-A nrPDB Length = 328 Score = 34.8 bits (78), Expect = 0.044, Method: Composition-based stats. Identities = 14/67 (20%), Positives = 26/67 (38%), Gaps = 1/67 (1%) Query: 9 LVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQ 68 LVTG IG + + L + +V + A + + + + Q DI D + Sbjct: 4 LVTGGAGFIGRWVVKRLLQDKH-EVWILDNLANSTTANITEFAHDLNLKQCIQGDIKDKK 62 Query: 69 SIRALRD 75 + L + Sbjct: 63 LVAQLFE 69 >4UUP-A nrPDB Length = 341 Score = 34.8 bits (78), Expect = 0.046, Method: Composition-based stats. Identities = 21/101 (20%), Positives = 38/101 (37%), Gaps = 15/101 (14%) Query: 8 ALVTGANRGIGLAIARELCRQ---FSGDVVLTARDVARGQAAVQ----QLQAEGLSPRFH 60 L+TGA IG A+A + + VVL ++ A++ +LQ Sbjct: 7 VLITGAAGQIGYALAFRIAKGDLFGDRKVVLHLLEIPPAMKALEGVCMELQDCAFPTLAG 66 Query: 61 QLDIDDLQ------SIRALRDFLRKEYG--GLNVLVNNAAV 93 + DD + + L ++ G ++L NA + Sbjct: 67 VVATDDPEEAFKDVDVAFLVGSFPRKPGMERADLLEKNAGI 107 >2WEK-A nrPDB Length = 341 Score = 34.4 bits (77), Expect = 0.055, Method: Composition-based stats. Identities = 25/168 (14%), Positives = 48/168 (28%), Gaps = 37/168 (22%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQL 62 S + LVT A G G A +L ++ V+ T L++ G Sbjct: 141 SEGKKVLVTAAAGGTGQ-FAMQLSKKAKCHVIGTCSS----DEKSAFLKSLG-------- 187 Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 ++ + G + K + P D+ E F Sbjct: 188 -------CDRPINYKTEPVGTV----------LKQEYPEGVDVVYESVGGAMF------- 223 Query: 123 NELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVD 170 + + + GR++ I + + S ++ L + V Sbjct: 224 DLAVDALATKGRLIVIGFISGYQTPTGLSPVKAGTLPAKLLKKSASVQ 271 >3S8M-A nrPDB Length = 422 Score = 34.4 bits (77), Expect = 0.056, Method: Composition-based stats. Identities = 18/96 (18%), Positives = 35/96 (36%), Gaps = 13/96 (13%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAV------------QQLQAE 53 + LV GA+ G GLA F D + + + + +A Sbjct: 62 KKVLVIGASSGYGLASRITAAFGFGADTLGVFFEKPGTASKAGTAGWYNSAAFDKHAKAA 121 Query: 54 GLSPRFHQLDIDDLQSIRALRDFLRKEYGG-LNVLV 88 GL + D + + + ++ E GG ++++V Sbjct: 122 GLYSKSINGDAFSDAARAQVIELIKTEMGGQVDLVV 157 >5N2I-A nrPDB Length = 232 Score = 33.2 bits (74), Expect = 0.14, Method: Composition-based stats. Identities = 16/50 (32%), Positives = 21/50 (42%), Gaps = 2/50 (4%) Query: 10 VTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRF 59 V G G +AR +V+L +R R QA +L EGL R Sbjct: 24 VLGGTGDQGRGLARRFAMA-GHEVILGSRSAERAQAVAAEL-GEGLPVRG 71 >3DMF-A nrPDB Length = 381 Score = 32.8 bits (73), Expect = 0.16, Method: Composition-based stats. Identities = 20/86 (23%), Positives = 31/86 (36%), Gaps = 14/86 (16%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 R L GA G A+ L R +VV D+A + + L+A L + D+ Sbjct: 234 GRQVLDLGAGYG---ALTLPLAR-MGAEVVGVEDDLASVLSLQKGLEANALKAQALHSDV 289 Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNN 90 D E +++V N Sbjct: 290 ----------DEALTEEARFDIIVTN 305 >1LU9-A nrPDB Length = 287 Score = 32.4 bits (72), Expect = 0.20, Method: Composition-based stats. Identities = 15/76 (19%), Positives = 25/76 (32%), Gaps = 2/76 (2%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 S + A+V +G+ A L + +VVL R + + QAA + Sbjct: 116 SVKGKKAVVLAGTGPVGMRSAALLAGE-GAEVVLCGRKLDKAQAAADSVNKR-FKVNVTA 173 Query: 62 LDIDDLQSIRALRDFL 77 + D S Sbjct: 174 AETADDASRAEAVKGA 189 >2Q1W-A nrPDB Length = 333 Score = 32.4 bits (72), Expect = 0.20, Method: Composition-based stats. Identities = 16/73 (21%), Positives = 26/73 (35%), Gaps = 6/73 (8%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 S +V +TG IG IA EL + VV + ++ + + F + Sbjct: 19 SHMKKV-FITGICGQIGSHIA-ELLLERGDKVVGIDNFATGRREHLK----DHPNLTFVE 72 Query: 62 LDIDDLQSIRALR 74 I D + L Sbjct: 73 GSIADHALVNQLI 85 >5F5N-A nrPDB Length = 289 Score = 32.1 bits (71), Expect = 0.25, Method: Composition-based stats. Identities = 17/73 (23%), Positives = 24/73 (32%), Gaps = 5/73 (6%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 +R LVTGA G A R L + R + R D+ Sbjct: 1 NRTILVTGATGTQGGATVRALLARGRPV-----RALVRDPGTDAARALAAAGVSLVTGDL 55 Query: 65 DDLQSIRALRDFL 77 +D S+RA + Sbjct: 56 NDQASLRAAMADV 68 >1IXR-A nrPDB Length = 191 Score = 32.1 bits (71), Expect = 0.25, Method: Composition-based stats. Identities = 15/80 (18%), Positives = 27/80 (33%), Gaps = 8/80 (10%) Query: 13 ANRGIGLAIARELCRQFSGDV-----VLTARDVARGQAAVQQLQAEGLS---PRFHQLDI 64 + G+G +A + + G V + + AV L A G R LD+ Sbjct: 111 SASGVGRRLAERIALELKGKVPPHLLAGEKVESEAAEEAVMALAALGFKEAQARAVVLDL 170 Query: 65 DDLQSIRALRDFLRKEYGGL 84 +D +++ L Sbjct: 171 LAQNPKARAQDLIKEALKRL 190 >5NUE-A nrPDB Length = 332 Score = 32.1 bits (71), Expect = 0.31, Method: Composition-based stats. Identities = 17/56 (30%), Positives = 24/56 (42%), Gaps = 4/56 (7%) Query: 8 ALVTGANRGIGLA----IARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRF 59 LVTGA IG A IAR + V+L D+ A+ ++ E + F Sbjct: 8 VLVTGAAGQIGYALVPMIARGIMLGADQPVILHMLDIPPAAEALNGVKMELIDAAF 63 >3ZU2-A nrPDB Length = 422 Score = 31.7 bits (70), Expect = 0.33, Method: Composition-based stats. Identities = 16/92 (17%), Positives = 30/92 (32%), Gaps = 12/92 (13%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTA--RDVARGQAAVQQL----------QAE 53 + LV GA+ G GLA D + R G+ + Sbjct: 65 KRVLVIGASTGYGLAARITAAFGCGADTLGVFFERPGEEGKPGTSGWYNSAAFHKFAAQK 124 Query: 54 GLSPRFHQLDIDDLQSIRALRDFLRKEYGGLN 85 GL + D + + D ++++ G ++ Sbjct: 125 GLYAKSINGDAFSDEIKQLTIDAIKQDLGQVD 156 >2C20-A nrPDB Length = 330 Score = 31.7 bits (70), Expect = 0.38, Method: Composition-based stats. Identities = 15/94 (15%), Positives = 32/94 (34%), Gaps = 15/94 (15%) Query: 9 LVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQ 68 L+ G IG ++L + VV+ + A+ + +F+ D+ D Sbjct: 5 LICGGAGYIGSHAVKKLVDE-GLSVVVVDNLQTGHEDAITE------GAKFYNGDLRDKA 57 Query: 69 SIRALRD----FLRKEYGGLNVLVNNAAVAFKSD 98 +R + + + LV V+ + Sbjct: 58 FLRDVFTQENIEAVMHFAA-DSLV---GVSMEKP 87 >4EJ0-A nrPDB Length = 342 Score = 31.3 bits (69), Expect = 0.41, Method: Composition-based stats. Identities = 20/127 (15%), Positives = 40/127 (31%), Gaps = 18/127 (14%) Query: 7 VALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDD 66 +VTGA IG + + L + ++ ++ R + +IDD Sbjct: 14 TLIVTGAAGFIGANLVKALNERGETRIIAVD-NLTRADKFKNLVD----------CEIDD 62 Query: 67 LQSIRALRD-FLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNEL 125 + F R ++G + AV + + + NF +R + + Sbjct: 63 YLDKTEFVERFARGDFGKVR------AVFHEGACSDTMETDGRYMMDNNFRYSRAVLDAC 116 Query: 126 LPIMKPH 132 L Sbjct: 117 LAQGAQF 123 >2EER-A nrPDB Length = 347 Score = 31.3 bits (69), Expect = 0.45, Method: Composition-based stats. Identities = 11/50 (22%), Positives = 23/50 (46%), Gaps = 1/50 (2%) Query: 4 CSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE 53 S+ +V GA G+G +A ++ + SG ++ A ++ A+ Sbjct: 170 PSKTLVVIGAGGGLG-TMAIQIAKAVSGATIIGVDVREEALEAAKRAGAD 218 >3QFK-A nrPDB Length = 527 Score = 31.3 bits (69), Expect = 0.50, Method: Composition-based stats. Identities = 9/53 (16%), Positives = 18/53 (33%) Query: 92 AVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIMKPHGRVVNISSLQCL 144 V + +P + E F + + + LP MK H ++ + Sbjct: 158 GVIGLTTQFIPHWEQPEHIQSLTFHSAFEILQQYLPEMKRHADIIVVCYHGGF 210 >5XW3-A nrPDB Length = 315 Score = 31.3 bits (69), Expect = 0.51, Method: Composition-based stats. Identities = 24/109 (22%), Positives = 36/109 (33%), Gaps = 28/109 (25%) Query: 11 TGANRGIGLAIA--------------------RELCRQFSGDVVLTARDV--ARGQAAVQ 48 T N GIGLA+A +EL + VV T + A + Sbjct: 71 TAGNTGIGLALAALQHDLRVIVCVPEKFSIEKQELMKALGATVVHTPTEQGMTGAIAKAK 130 Query: 49 QLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEY-----GGLNVLVNNAA 92 +L E + + + + RA L E G +N+ V A Sbjct: 131 ELVNEIPNS-YSPSQFANEANPRAYFKTLGPELWSALNGEINIFVAGAG 178 >4AR0-A nrPDB Length = 128 Score = 30.9 bits (68), Expect = 0.56, Method: Composition-based stats. Identities = 24/93 (25%), Positives = 40/93 (43%), Gaps = 21/93 (22%) Query: 52 AEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVL----VNNAAVAFKSDDPMPFDIKA 107 A G + R LD D++ IR + L KE G +N++ VN S +P+D Sbjct: 26 AMGFTGRKISLDFQDVE-IRTILQILAKESG-MNIVASDSVN--GKMTLSLKDVPWDQAL 81 Query: 108 EMTLKT-NFFATRNMCNELLPIMKPHGRVVNIS 139 ++ ++ N M+ G +VNI+ Sbjct: 82 DLVMQARNLD------------MRQQGNIVNIA 102 >5U9C-A nrPDB Length = 292 Score = 30.9 bits (68), Expect = 0.57, Method: Composition-based stats. Identities = 14/74 (18%), Positives = 26/74 (35%), Gaps = 4/74 (5%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARG---QAAVQQLQAEGLSPR 58 ++ R L+TG +G A + +V++T R+ +A + AE Sbjct: 2 NAMKRKILITGGTGMLG-AYVTSALKDTDYNVIVTERNTLNLSVPEAIFSYITAEKPDVI 60 Query: 59 FHQLDIDDLQSIRA 72 H D+ Sbjct: 61 LHFAAETDVDLCER 74 >1DB3-A nrPDB Length = 372 Score = 30.9 bits (68), Expect = 0.57, Method: Composition-based stats. Identities = 15/78 (19%), Positives = 27/78 (34%), Gaps = 4/78 (5%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTAR----DVARGQAAVQQLQAEGLSPRFH 60 S+VAL+TG G +A L + + R + R Q H Sbjct: 1 SKVALITGVTGQDGSYLAEFLLEKGYEVHGIKRRASSFNTERVDHIYQDPHTCNPKFHLH 60 Query: 61 QLDIDDLQSIRALRDFLR 78 D+ D ++ + ++ Sbjct: 61 YGDLSDTSNLTRILREVQ 78 >2Z95-A nrPDB Length = 345 Score = 30.9 bits (68), Expect = 0.59, Method: Composition-based stats. Identities = 14/78 (17%), Positives = 31/78 (39%), Gaps = 5/78 (6%) Query: 3 SCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGL--SPRFH 60 + AL+TG RG A +L + +V R + +L+ G+ + Sbjct: 1 MSGKRALITG-IRGQDGAYLAKLLLEKGYEVYGADRRSGEFASW--RLKELGIENDVKII 57 Query: 61 QLDIDDLQSIRALRDFLR 78 +D+ + +I + ++ Sbjct: 58 HMDLLEFSNIIRTIEKVQ 75 >1OOE-A nrPDB Length = 236 Score = 30.5 bits (67), Expect = 0.88, Method: Composition-based stats. Identities = 32/212 (15%), Positives = 61/212 (28%), Gaps = 32/212 (15%) Query: 30 SGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVN 89 SG V++ A G A ++ + G + L +D N+LV+ Sbjct: 3 SGKVIVYGGKGALGSAILEFFKKNGYTVLNIDLSANDQADS--------------NILVD 48 Query: 90 NAAVAFKSDDPMPFDIKAEMTLKTN-FFATRNMCNELLPIMKPHGRVVNISSLQCLRAFE 148 ++ + +L+ + + S + Sbjct: 49 --GNKNWTEQEQSILEQTASSLQGSQVDGVFCVAGGWAG-----------GSASSKDFVK 95 Query: 149 NCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNS--PYGVSKLGVTVLSR 206 N +++ S + +K G S YG++K V L+ Sbjct: 96 NADLMIKQSVWSSAIAAKLATTHLKPGGLLQLTGAAAAMGPTPSMIGYGMAKAAVHHLTS 155 Query: 207 ILARRLDEKRKADRILVNACCPGPVKTDMDGK 238 LA + + D V P + T M+ K Sbjct: 156 SLAAK--DSGLPDNSAVLTIMPVTLDTPMNRK 185 >3R9I-A nrPDB Length = 260 Score = 30.5 bits (67), Expect = 0.90, Method: Composition-based stats. Identities = 11/37 (29%), Positives = 18/37 (48%), Gaps = 5/37 (13%) Query: 4 CSRVALVTGANRGIGL-----AIARELCRQFSGDVVL 35 +R+ +VT G+G AIA L ++ VV+ Sbjct: 1 MARIIVVTSGKGGVGKTTSSAAIATGLAQKGKKTVVI 37 >4KTT-E nrPDB Length = 327 Score = 30.5 bits (67), Expect = 0.91, Method: Composition-based stats. Identities = 31/186 (16%), Positives = 60/186 (32%), Gaps = 27/186 (14%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61 + +R LVTGA +G A+ +E +Q + V AR P+F Q Sbjct: 18 NIPNRRVLVTGATGLLGRAVHKEF-QQNNWHAVGCGFRRAR--------------PKFEQ 62 Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121 +++ D ++ + + V+V+ AA P + + + + N A+ N+ Sbjct: 63 VNLLDSNAVHHIIHDFQPH-----VIVHCAA----ERRPDVVENQPDAASQLNVDASGNL 113 Query: 122 CNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKN 181 E + ++ ISS + + L + Sbjct: 114 AKEAAAV---GAFLIYISSDYVFDGTNPPYREEDIPAPLNLYGKTKLDGEKAVLENNLGA 170 Query: 182 EVHERE 187 V Sbjct: 171 AVLRIP 176 >3T69-A nrPDB Length = 330 Score = 30.1 bits (66), Expect = 0.99, Method: Composition-based stats. Identities = 16/61 (26%), Positives = 22/61 (36%) Query: 17 IGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDF 76 IGL IA L S D V G L+++GL+ R D + A Sbjct: 245 IGLEIAGALAGSGSVDGVCLVGSGGLGTLYRTALESQGLNVRAVDADEAVRAGLSAAARA 304 Query: 77 L 77 + Sbjct: 305 I 305 >5UZH-A nrPDB Length = 345 Score = 30.1 bits (66), Expect = 1.0, Method: Composition-based stats. Identities = 13/78 (16%), Positives = 30/78 (38%), Gaps = 4/78 (5%) Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTAR----DVARGQAAVQQLQAEGLSPRFH 60 S+VAL+TG G +A L + + R + R + + + + Sbjct: 1 SKVALITGITGQDGSYLAEFLLEKGYMVYGIIRRSSSFNTGRVEHLYKDIHITKAKFKLL 60 Query: 61 QLDIDDLQSIRALRDFLR 78 D+ D ++ ++ ++ Sbjct: 61 YGDLTDTGNLISIIAKIK 78 >4BKO-A nrPDB Length = 417 Score = 30.1 bits (66), Expect = 1.1, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 31/95 (32%), Gaps = 12/95 (12%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAV------------QQLQAE 53 + LV GA+ G GLA + + A A + A Sbjct: 62 KKVLVIGASTGYGLAARIAAAFGAGAATLGVFFERAPADAKPGTAGWYNSAAFHDEAAAR 121 Query: 54 GLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLV 88 GL D + D +R++ G ++++V Sbjct: 122 GLQATSVNGDAFSDEIKHKTIDAIRRDLGQVDLVV 156 >1O89-A nrPDB Length = 345 Score = 30.1 bits (66), Expect = 1.2, Method: Composition-based stats. Identities = 12/48 (25%), Positives = 23/48 (47%), Gaps = 5/48 (10%) Query: 9 LVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLS 56 +VTGA+ G+G L + V ++ R ++ + L++ G S Sbjct: 172 VVTGASGGVGSTAVALLHKLGYQVVAVSGR-----ESTHEYLKSLGAS 214 >4WOK-A nrPDB Length = 336 Score = 29.8 bits (65), Expect = 1.2, Method: Composition-based stats. Identities = 19/76 (25%), Positives = 27/76 (35%), Gaps = 10/76 (13%) Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 MS+ + LV G IG A+ L Q VV Q+AV+ F Sbjct: 9 MSANN--VLVVGGAGFIGSHTAKLLAGQGYAPVV-YDNLSTGHQSAVRW-------GDFV 58 Query: 61 QLDIDDLQSIRALRDF 76 + DI D + + Sbjct: 59 EGDILDQARLVETMEK 74 >2C54-A nrPDB Length = 379 Score = 29.8 bits (65), Expect = 1.3, Method: Composition-based stats. Identities = 21/128 (16%), Positives = 48/128 (37%), Gaps = 13/128 (10%) Query: 10 VTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQS 69 +TGA I IAR L + + A D + + + + + FH +D+ +++ Sbjct: 34 ITGAGGFIASHIARRLKHEGHYVI---ASDWKKNEHMTEDMFCD----EFHLVDLRVMEN 86 Query: 70 IRALRD------FLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCN 123 + + L + GG+ + +N +V ++ + F++ + Sbjct: 87 CLKVTEGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMIEAARINGIKRFFYASSA 146 Query: 124 ELLPIMKP 131 + P K Sbjct: 147 CIYPEFKQ 154 >4BKP-A nrPDB Length = 336 Score = 29.8 bits (65), Expect = 1.4, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 27/77 (35%), Gaps = 26/77 (33%) Query: 9 LVTGANRGIGLAIARELCRQFSGD----VVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64 LVTG + +G AI + + V ++++D D+ Sbjct: 26 LVTGGSGLVGKAIQKVVADGAGLPGEDWVFVSSKD----------------------ADL 63 Query: 65 DDLQSIRALRDFLRKEY 81 D RAL + ++ + Sbjct: 64 TDTAQTRALFEKVQPTH 80 >3F6S-A nrPDB Length = 148 Score = 29.8 bits (65), Expect = 1.4, Method: Composition-based stats. Identities = 15/85 (17%), Positives = 31/85 (36%), Gaps = 9/85 (10%) Query: 4 CSRVALVTGANRGIGLAIAR---ELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60 S+V +V G++ G +IA+ EL +V L A + A+G Sbjct: 1 MSKVLIVFGSSTGNTESIAQKLEELIAAGGHEVTLL-----NAADASAENLADGYDAVLF 55 Query: 61 QLDIDDLQSIRALRDFLRKEYGGLN 85 ++ + ++D + + Sbjct: 56 GCSAWGMEDLE-MQDDFLSLFEEFD 79 >4E0B-A nrPDB Length = 313 Score = 29.8 bits (65), Expect = 1.5, Method: Composition-based stats. Identities = 14/40 (35%), Positives = 21/40 (52%), Gaps = 1/40 (2%) Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVA 41 S+ +VA++ GA GIG A+A L + L D+A Sbjct: 1 SNAMKVAVI-GAAGGIGQALALLLKNRLPAGSDLALYDIA 39 >5A3V-A nrPDB Length = 329 Score = 29.4 bits (64), Expect = 1.9, Method: Composition-based stats. Identities = 15/60 (25%), Positives = 24/60 (40%), Gaps = 10/60 (16%) Query: 4 CSRVA--LVTGANRGIGLAIARELCRQFSGDVVLT--ARDVA-----RGQAAVQQLQAEG 54 + A LVT A+ G+G A +L + + V T AR++ + EG Sbjct: 153 TGKKANILVTAASGGVG-HYAVQLAKLANAHVTATCGARNIEFVKSLGADEVLDYKTPEG 211 >1JAY-A nrPDB Length = 212 Score = 29.4 bits (64), Expect = 1.9, Method: Composition-based stats. Identities = 15/76 (19%), Positives = 28/76 (36%), Gaps = 1/76 (1%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 RVAL+ G +G +A L VV + R+ A + + G + + D Sbjct: 2 RVALL-GGTGNLGKGLALRLATLGHEIVVGSRREEKAEAKAAEYRRIAGDASITGMKNED 60 Query: 66 DLQSIRALRDFLRKEY 81 ++ + E+ Sbjct: 61 AAEACDIAVLTIPWEH 76 >2X86-A nrPDB Length = 357 Score = 29.0 bits (63), Expect = 2.1, Method: Composition-based stats. Identities = 15/81 (18%), Positives = 28/81 (34%), Gaps = 13/81 (16%) Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65 R+ +VTG IG I + L + D+++ L+ L+I Sbjct: 47 RMIIVTGGAGFIGSNIVKALNDKGITDILVVDN-----------LKDGTKFVNLVDLNIA 95 Query: 66 DLQSIRALRDFLR--KEYGGL 84 D + +E+G + Sbjct: 96 DYMDKEDFLIQIMAGEEFGDV 116 >1CJA-A nrPDB Length = 342 Score = 29.0 bits (63), Expect = 2.2, Method: Composition-based stats. Identities = 36/181 (19%), Positives = 66/181 (36%), Gaps = 15/181 (8%) Query: 92 AVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCS 151 + F + F +K +++ F + L K RVV+ +S + E + Sbjct: 83 GLFFVETESGVFIVKRSTNIESETFCSLLCMRLGLHAPKV--RVVSSNSEEGTNMLECLA 140 Query: 152 EDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARR 211 + TL + LM+ T N++ VL++ ++ Sbjct: 141 AIDKSFRVITTLANQANILLMELVRGITLNKLTTTSAP------------EVLTKSTMQQ 188 Query: 212 LDEKRKADRILVNACCPGPVKTDMDGKDSIRTVEEGAET-PVYLALLPPDATEPQGQLVH 270 L D I+ N+ T+ D+I E GA P+ ++P DA+ P G+ V Sbjct: 189 LGSLMALDVIVNNSDRLPIAWTNEGNLDNIMLSERGATVVPIDSKIIPLDASHPHGERVR 248 Query: 271 D 271 + Sbjct: 249 E 249 >3CT4-A nrPDB Length = 332 Score = 29.0 bits (63), Expect = 2.4, Method: Composition-based stats. Identities = 15/101 (14%), Positives = 34/101 (33%), Gaps = 17/101 (16%) Query: 4 CSRVALVTGANRG--------IGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGL 55 +VALV+G G +G + L G + + +A + G+ Sbjct: 45 SGKVALVSGGGSGHEPAHAGFVGEGM---LSAAVCGAIFTSPTPDQIYEAIKSADEGAGV 101 Query: 56 SPRF--HQLDIDDLQSIRALRDFLRKEYGGL----NVLVNN 90 + D+ + + R + + + + ++ V N Sbjct: 102 LLIIKNYLGDVMNFEMAREMAEMEEIKVEQIIVDDDIAVEN 142 >4EJ6-A nrPDB Length = 370 Score = 29.0 bits (63), Expect = 2.6, Method: Composition-based stats. Identities = 19/88 (21%), Positives = 36/88 (40%), Gaps = 9/88 (10%) Query: 7 VALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDD 66 VA++ G IGL + L R V+ + A + +++ A +D Sbjct: 186 VAILGGGV--IGLLTVQ-LARLAGATTVILSTRQATKRRLAEEVGA------TATVDPSA 236 Query: 67 LQSIRALRDFLRKEYGGLNVLVNNAAVA 94 + A+ + GG++V++ A VA Sbjct: 237 GDVVEAIAGPVGLVPGGVDVVIECAGVA 264 >4P4L-A nrPDB Length = 277 Score = 28.6 bits (62), Expect = 3.0, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 22/68 (32%) Query: 13 ANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRA 72 + G A L D+ + AR+ + V G++ RF D L A Sbjct: 124 GSGGTAPAAVVGLAELGVTDITVVARNSDKAARLVDLGTRVGVATRFCAFDSGGLADAVA 183 Query: 73 LRDFLRKE 80 + L Sbjct: 184 AAEVLVST 191 >3JYO-A nrPDB Length = 283 Score = 28.6 bits (62), Expect = 3.1, Method: Composition-based stats. Identities = 10/61 (16%), Positives = 20/61 (32%) Query: 20 AIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRK 79 A+A L + + D +R QA + +D ++ + A D + Sbjct: 141 AVAYALVTHGVQKLQVADLDTSRAQALADVINNAVGREAVVGVDARGIEDVIAAADGVVN 200 Query: 80 E 80 Sbjct: 201 A 201 >5GXF-A nrPDB Length = 330 Score = 28.6 bits (62), Expect = 3.1, Method: Composition-based stats. Identities = 9/37 (24%), Positives = 14/37 (37%), Gaps = 1/37 (2%) Query: 8 ALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQ 44 LVTGA G+G ++A + +V Sbjct: 153 VLVTGAAGGVG-SVATAILAHLGYEVAAVTGRPETAD 188 >2DFV-A nrPDB Length = 347 Score = 28.2 bits (61), Expect = 3.5, Method: Composition-based stats. Identities = 13/73 (17%), Positives = 25/73 (34%), Gaps = 19/73 (26%) Query: 4 CSRVALVTGAN--RGIGLAIA-----------------RELCRQFSGDVVLTARDVARGQ 44 + L+TGA +G+A+A REL ++ D V+ + + Sbjct: 166 SGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVK 225 Query: 45 AAVQQLQAEGLSP 57 + G+ Sbjct: 226 EVMDITDGNGVDV 238 >5M58-A nrPDB Length = 230 Score = 28.2 bits (61), Expect = 3.7, Method: Composition-based stats. Identities = 18/108 (16%), Positives = 34/108 (31%), Gaps = 26/108 (24%) Query: 32 DVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNA 91 ++V + A +G F D + L G +++V+ Sbjct: 65 NLVGVDLSEDMVRIARDYAAEQGKELEFRHGDAQSPAGMEDL-------LGKADLVVSRH 117 Query: 92 AVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIMKPHGRVVNIS 139 A + P FD +L ++KP G ++N+S Sbjct: 118 AFHRLTRLPAGFDT-------------------MLRLVKPGGAILNVS 146 >3CJR-A nrPDB Length = 254 Score = 28.2 bits (61), Expect = 4.0, Method: Composition-based stats. Identities = 17/79 (21%), Positives = 27/79 (34%), Gaps = 15/79 (18%) Query: 12 GANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIR 71 G G+ LAIA + G + D A + G+ PRF + + Sbjct: 128 GTGSGV-LAIA---AEKLGGKALGVDIDPMVLPQAEANAKRNGVRPRFLEGSL------- 176 Query: 72 ALRDFLRKEYGGLNVLVNN 90 +G ++LV N Sbjct: 177 ----EAALPFGPFDLLVAN 191 >1TLL-A nrPDB Length = 688 Score = 28.2 bits (61), Expect = 4.1, Method: Composition-based stats. Identities = 11/76 (14%), Positives = 27/76 (35%), Gaps = 11/76 (14%) Query: 43 GQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGL---NVLVNNAA--VAFKS 97 ++ + L+ +G + D+ + + + G L + A ++ Sbjct: 591 AESVYRALKEQGGH-IYVCGDVTMAADVLKAIQRIMTQQGKLSEED-----AGVFISRLR 644 Query: 98 DDPMPFDIKAEMTLKT 113 DD + +TL+T Sbjct: 645 DDNRYHEDIFGVTLRT 660 >6H5E-B nrPDB Length = 437 Score = 28.2 bits (61), Expect = 4.3, Method: Composition-based stats. Identities = 4/19 (21%), Positives = 9/19 (47%) Query: 72 ALRDFLRKEYGGLNVLVNN 90 +G ++++VNN Sbjct: 130 NFFRDQMDRFGEIDIMVNN 148 >4WJL-A nrPDB Length = 719 Score = 27.8 bits (60), Expect = 4.6, Method: Composition-based stats. Identities = 12/25 (48%), Positives = 13/25 (52%) Query: 253 YLALLPPDATEPQGQLVHDKVVQNW 277 ALL EP GQLV DK +W Sbjct: 496 QYALLLIMDEEPGGQLVTDKFHIDW 520 >5G1T-A nrPDB Length = 256 Score = 27.4 bits (59), Expect = 6.4, Method: Composition-based stats. Identities = 21/164 (12%), Positives = 44/164 (26%), Gaps = 22/164 (13%) Query: 24 ELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID-DLQSIRALRDFLRKEYG 82 L + VV+ + V + G LD+ D + + +E Sbjct: 93 ALLKAGVARVVIGSTAVKSPDVVKGWFERFGAQALVLALDVRIDEHGTKQVAVSGWQE-- 150 Query: 83 GLNVLVNNAAVAFKSDDPMP----------FDIKAEMTLKTNFFATRNMCNELLPIM--K 130 N+ V+ + DI + TL + + P + + Sbjct: 151 -------NSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQIAFQ 203 Query: 131 PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKK 174 G + +I + LR + T + + + Sbjct: 204 SSGGIGDIDDIAALRGTGVRGVIVGRALLEGKFTVKEAIQCWQN 247 >2Z4U-A nrPDB Length = 261 Score = 27.4 bits (59), Expect = 7.3, Method: Composition-based stats. Identities = 16/73 (21%), Positives = 29/73 (39%), Gaps = 9/73 (12%) Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122 DI + + D E+ +LV A+ S+ E +KTNF N Sbjct: 147 DIGKISGVSTFTDKTEAEF----LLV---AIQMVSEAARF--KYIENQVKTNFNRAFNPN 197 Query: 123 NELLPIMKPHGRV 135 ++L + + G++ Sbjct: 198 PKVLSLEENWGKI 210 >3L6V-A nrPDB Length = 370 Score = 27.4 bits (59), Expect = 7.7, Method: Composition-based stats. Identities = 15/85 (17%), Positives = 28/85 (32%), Gaps = 12/85 (14%) Query: 3 SCSRVALVTGANRGI----GLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPR 58 S R A TG RGI G + + + +G V + + +++ Sbjct: 183 SMGRTA--TGV-RGIRLAKGEEVVSLIVSERAGGV-----EDEVEDESAEEVVETTDGAE 234 Query: 59 FHQLDIDDLQSIRALRDFLRKEYGG 83 +D+ D + + YG Sbjct: 235 PAVIDVADNGDVAYILTATENGYGK 259 >6MX4-A nrPDB Length = 441 Score = 27.1 bits (58), Expect = 8.7, Method: Composition-based stats. Identities = 15/70 (21%), Positives = 20/70 (28%), Gaps = 2/70 (2%) Query: 136 VNI--SSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSP 193 VNI S+ A + + + L G L F HE + Sbjct: 133 VNITYGSVSWRSADVYVNGETPAKIGDAKLIIGPLSSAWSPFDNKVVVYGHEVYNYDFPE 192 Query: 194 YGVSKLGVTV 203 YG K G Sbjct: 193 YGTGKAGSFG 202 >1VL2-A nrPDB Length = 421 Score = 27.1 bits (58), Expect = 9.5, Method: Composition-based stats. Identities = 7/49 (14%), Positives = 16/49 (32%) Query: 32 DVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKE 80 VVL ++ L +G + ++ A+++ K Sbjct: 16 KVVLAYSGGLDTSVILKWLCEKGFDVIAYVANVGQKDDFVAIKEKALKT 64 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.124 0.347 Lambda K H 0.267 0.0382 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 9,945,370 Number of Sequences: 36641 Number of extensions: 361310 Number of successful extensions: 2308 Number of sequences better than 10.0: 280 Number of HSP's better than 10.0 without gapping: 284 Number of HSP's successfully gapped in prelim test: 132 Number of HSP's that attempted gapping in prelim test: 1328 Number of HSP's gapped (non-prelim): 639 length of query: 277 length of database: 10,336,785 effective HSP length: 96 effective length of query: 181 effective length of database: 6,819,249 effective search space: 1234284069 effective search space used: 1234284069 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 58 (27.1 bits)