BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= O75530 (441 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3JZG-A nrPDB 846 0.0 5BJS-A nrPDB 130 1e-30 5NNZ-B nrPDB 65 5e-11 6F3T-A nrPDB 54 1e-07 5MZH-A nrPDB 54 1e-07 6MZM-G nrPDB 54 1e-07 1VYH-C nrPDB 52 4e-07 2H9P-A nrPDB 52 7e-07 5OPT-p nrPDB 51 8e-07 5M25-A nrPDB 51 1e-06 3JB9-g nrPDB 50 2e-06 5XYI-g nrPDB 50 2e-06 5FL8-q nrPDB 50 3e-06 4V8M-A7 nrPDB 50 3e-06 6J6H-n nrPDB 49 5e-06 5OQL-X nrPDB 48 8e-06 6QX9-5O nrPDB 48 8e-06 3JAP-g nrPDB 47 2e-05 4BTS-AR nrPDB 46 3e-05 3FM0-A nrPDB 45 5e-05 6HQA-B nrPDB 45 5e-05 4V6W-Ag nrPDB 45 6e-05 5K1B-B nrPDB 45 7e-05 3DM0-A nrPDB 45 9e-05 6ID0-T nrPDB 44 1e-04 5Y88-O nrPDB 44 1e-04 2YNP-A nrPDB 44 2e-04 6HHQ-h nrPDB 44 2e-04 6QX9-4B nrPDB 43 2e-04 4XYI-A nrPDB 43 3e-04 5GAN-H nrPDB 42 4e-04 3MKQ-A nrPDB 42 6e-04 6G51-g nrPDB 40 0.002 6Q8F-A nrPDB 40 0.002 4U1E-I nrPDB 40 0.003 5YZG-W nrPDB 39 0.004 5I2T-A nrPDB 39 0.004 6QDV-o nrPDB 39 0.004 5WLC-LO nrPDB 39 0.005 6EOJ-D nrPDB 39 0.006 4V7E-Bg nrPDB 39 0.006 5K0Y-T nrPDB 38 0.008 6GMH-W nrPDB 38 0.008 5OQL-d nrPDB 38 0.009 3CFV-B nrPDB 38 0.010 2AQ5-A nrPDB 37 0.013 5WYJ-BC nrPDB 37 0.014 5FVM-C nrPDB 37 0.016 6N9G-C nrPDB 37 0.017 5WLC-LJ nrPDB 37 0.018 5CXC-A nrPDB 37 0.019 4BH6-A nrPDB 37 0.021 5NZU-C nrPDB 37 0.023 5A9Q-2 nrPDB 37 0.025 5Y1U-A nrPDB 36 0.027 5A31-R nrPDB 36 0.028 4PSX-B nrPDB 36 0.037 5WJC-A nrPDB 36 0.040 6EMK-B nrPDB 35 0.045 3C9C-A nrPDB 35 0.050 3ACP-A nrPDB 35 0.059 5MWJ-A nrPDB 35 0.074 5WYK-BB nrPDB 35 0.081 4A11-B nrPDB 34 0.099 3W15-A nrPDB 34 0.11 5L9T-R nrPDB 34 0.14 5WYJ-BE nrPDB 34 0.15 6CVZ-A nrPDB 33 0.17 4FHN-A nrPDB 33 0.17 5FA5-B nrPDB 33 0.20 2HES-X nrPDB 33 0.33 3JB9-L nrPDB 32 0.44 4AEZ-A nrPDB 32 0.49 2PM9-A nrPDB 32 0.60 5OQL-J nrPDB 31 0.86 5MC6-j nrPDB 31 1.1 4LG8-A nrPDB 31 1.3 5A9Q-0 nrPDB 31 1.3 6BX3-A nrPDB 30 1.7 5Z56-q nrPDB 30 1.8 4G56-B nrPDB 30 1.8 6CHG-A nrPDB 30 1.8 4OWR-A nrPDB 30 1.8 2I2W-A nrPDB 30 2.2 5G04-R nrPDB 30 2.9 4GGA-A nrPDB 29 3.3 1PI6-A nrPDB 29 3.4 5LCW-Q nrPDB 29 3.4 1X7P-A nrPDB 29 3.5 5A9Q-7 nrPDB 29 4.6 4N14-A nrPDB 29 4.7 3ODT-A nrPDB 28 6.1 6N8P-A nrPDB 28 7.5 5TF2-A nrPDB 28 7.5 5IV7-F nrPDB 28 7.6 5WLC-LU nrPDB 28 7.8 6BX3-B nrPDB 28 8.6 >3JZG-A nrPDB Length = 402 Score = 846 bits (2186), Expect = 0.0, Method: Compositional matrix adjust. Identities = 402/402 (100%), Positives = 402/402 (100%) Query: 40 DAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGV 99 DAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGV Sbjct: 1 DAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGV 60 Query: 100 QFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTS 159 QFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTS Sbjct: 61 QFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTS 120 Query: 160 HPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWN 219 HPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWN Sbjct: 121 HPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWN 180 Query: 220 IQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 279 IQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD Sbjct: 181 IQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 240 Query: 280 YNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDD 339 YNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDD Sbjct: 241 YNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDD 300 Query: 340 IDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKA 399 IDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKA Sbjct: 301 IDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKA 360 Query: 400 KCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 441 KCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR Sbjct: 361 KCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 402 >5BJS-A nrPDB Length = 605 Score = 130 bits (327), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 101/335 (30%), Positives = 152/335 (45%), Gaps = 56/335 (16%) Query: 96 LFGVQFNWHSKEGDPLVFATVGSN-----RVTLYECHSQGEIRLLQSYVDADADENFYTC 150 F V+F +S G P VFA R+T ++Q D + N +C Sbjct: 80 FFDVKFYPYSPPGAPPVFAATSKKHAVICRLTQTTDKDANPCEIIQLIRDDGNEANCASC 139 Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS 210 W+ D T PLL +AG+ G +++ N + + VGHG IN+L P +P ++ S S Sbjct: 140 -WSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASAS 198 Query: 211 KDHALRLWNI----QTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRIN 266 D +R+W++ + V I GG EGH ++LS + G ++S G D + LW Sbjct: 199 DDTTIRIWSLAPEHEKQPCVCILGG-EGHSYDLLSVAFHDNGRYVLSAGHDQVINLW--- 254 Query: 267 SKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSC-E 325 A+ E PN+ I I++P FS+ +IH N VDCV + GDLILS++C E Sbjct: 255 ------ALPEF----PNEHME--IPIVIYYPHFSSSEIHNNLVDCVAFYGDLILSRACHE 302 Query: 326 NAIVCWK-PGKMEDD-----IDKIKPSE-------------------SNVTILGRFDYSQ 360 + IV W+ G DD +D P++ + T L +F Sbjct: 303 DTIVLWRIEGFSSDDPIPGPLDAPTPTDMTKQTRSYFTPTVSPQSRPAMFTRLAQFHTPD 362 Query: 361 CDI-WYMRFSMDFW---QKMLALGNQVGKLYVWDL 391 C + ++MRF M +LA N K + WDL Sbjct: 363 CGVQFFMRFRMYHVPGKHPILAFANAKSKTFFWDL 397 >5NNZ-B nrPDB Length = 415 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 33/103 (32%), Positives = 58/103 (56%), Gaps = 4/103 (3%) Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221 L+A A + G RI + T +CI GH I+++ F+P+ N LL+ S D R+W+ Q Sbjct: 317 LIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQG-NHLLTGSSDKTARIWDAQ 375 Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 T + + +EGH DE+ S ++ G +++ D++ ++WR Sbjct: 376 TGQCLQV---LEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 27/96 (28%), Positives = 51/96 (53%), Gaps = 4/96 (4%) Query: 179 TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDE 238 T +C + GH I L F+P+ L+ + S D +LW+IQ V + GH E Sbjct: 166 TGKCYHTFRGHTAEIVCLSFNPQ-STLVATGSMDTTAKLWDIQNGEEVYT---LRGHSAE 221 Query: 239 VLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAI 274 ++S ++ G++I++ DH++ +W ++ R +N + Sbjct: 222 IISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNIL 257 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 22/89 (24%), Positives = 46/89 (51%), Gaps = 4/89 (4%) Query: 187 VGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDL 246 +GH I+ F+ D +L+L+ S D +LW+ VA + GH DE+L + +D Sbjct: 258 IGHCAEISSASFN-WDCSLILTGSMDKTCKLWDATNGKCVAT---LTGHDDEILDSCFDY 313 Query: 247 LGEKIMSCGMDHSLKLWRINSKRMMNAIK 275 G+ I + D + +++ +++ + ++ Sbjct: 314 TGKLIATASADGTARIFSAATRKCIAKLE 342 Score = 33.9 bits (76), Expect = 0.16, Method: Compositional matrix adjust. Identities = 19/88 (21%), Positives = 40/88 (45%), Gaps = 3/88 (3%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247 GH N + + F+ + + + S D +LW+++T F GH E++ ++ Sbjct: 132 GHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTF---RGHTAEIVCLSFNPQ 188 Query: 248 GEKIMSCGMDHSLKLWRINSKRMMNAIK 275 + + MD + KLW I + + ++ Sbjct: 189 STLVATGSMDTTAKLWDIQNGEEVYTLR 216 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 19/99 (19%), Positives = 44/99 (44%), Gaps = 4/99 (4%) Query: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 240 +C+ GH + I + F L+ + S D R+++ T +A +EGH E+ Sbjct: 294 KCVATLTGHDDEILDSCF-DYTGKLIATASADGTARIFSAATRKCIA---KLEGHEGEIS 349 Query: 241 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 279 ++ G +++ D + ++W + + + ++ D Sbjct: 350 KISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTD 388 >6F3T-A nrPDB Length = 608 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 47/184 (25%), Positives = 88/184 (47%), Gaps = 20/184 (10%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVT-LYECHSQGEIRLLQSYV 139 +F C+ K HN P++ QF+ + F + G +RV L+ +R+ ++ Sbjct: 382 TFTCLVGYK-GHNYPVWDTQFSPYG-----YYFVSGGHDRVARLWATDHYQPLRIFAGHL 435 Query: 140 DADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFH 199 AD N C + N+++ +A + +R+ + + C++ + GH I+ L F Sbjct: 436 ---ADVN---CT-RFHPNSNY--VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFS 486 Query: 200 PRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHS 259 P + L + + D + LW+I +V G ++GH D V S + GE + S MD++ Sbjct: 487 P-NGRFLATGATDGRVLLWDIGHGLMV---GELKGHTDTVCSLRFSRDGEILASGSMDNT 542 Query: 260 LKLW 263 ++LW Sbjct: 543 VRLW 546 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 65/269 (24%), Positives = 101/269 (37%), Gaps = 52/269 (19%) Query: 173 RIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGV 232 RI++ T +K GH + F P D N LLS S+D +RLW++QT T + G Sbjct: 334 RIMDEKTASELKILYGHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFTCLV---GY 389 Query: 233 EGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQ 292 +GH V + G +S G D +LW + Y P R F Sbjct: 390 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDH------------YQP---LRIFAG- 433 Query: 293 KIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTI 352 H D + H N + + + S + + W D+ N Sbjct: 434 --HLADVNCTRFHPN--------SNYVATGSADRTVRLW-------DV-------LNGNC 469 Query: 353 LGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAA 412 + F + I + FS + + LA G G++ +WD+ H L H Sbjct: 470 VRIFTGHKGPIHSLTFSPN--GRFLATGATDGRVLLWDI----GHGLMVGELKGHT--DT 521 Query: 413 IRQTSFSRDSSILIAVCDDASIWRWDRLR 441 + FSRD IL + D ++ WD ++ Sbjct: 522 VCSLRFSRDGEILASGSMDNTVRLWDAIK 550 Score = 32.3 bits (72), Expect = 0.41, Method: Compositional matrix adjust. Identities = 49/248 (19%), Positives = 91/248 (36%), Gaps = 34/248 (13%) Query: 148 YTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLL 207 Y +++ D N L + G +R+ + T C+ Y GH + + +F P + Sbjct: 355 YGASFSPDRN----YLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYG-YYFV 409 Query: 208 SVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI-- 265 S D RLW + IF GH +V + + + D +++LW + Sbjct: 410 SGGHDRVARLWATDHYQPLRIFA---GHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 466 Query: 266 -NSKRMMNAIK---ESYDYNPN--------KTNRPFISQKIHFPDFSTRDIHRNYVDCVR 313 N R+ K S ++PN R + H H + V +R Sbjct: 467 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLR 526 Query: 314 WL--GDLILSKSCENAIVCWKPGKMEDDIDKIK----------PSESNVTILGRFDYSQC 361 + G+++ S S +N + W K +D++ P S +LG + Sbjct: 527 FSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKST 586 Query: 362 DIWYMRFS 369 + ++ F+ Sbjct: 587 PVVHLHFT 594 >5MZH-A nrPDB Length = 452 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 43/182 (23%), Positives = 84/182 (46%), Gaps = 18/182 (9%) Query: 83 KCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDAD 142 +CV+ L H + QFN+ G +V ++ L++ S + + Q + D Sbjct: 254 QCVHVLS-GHRGEVSSTQFNY---AGTLVVSGSIDCTS-RLWDVRSGRCLSVKQGHTDEV 308 Query: 143 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRD 202 D F + + + A + G R+ + +T C VGH I+++ F+P+ Sbjct: 309 LDVAF---------DAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNPQG 359 Query: 203 PNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKL 262 L+ + S D RLW+ T + + +EGH DE+ S ++ G+ I++ D++ ++ Sbjct: 360 TRLI-TASSDKTCRLWDCDTGECLQV---LEGHTDEIFSCAFNYEGDFIITGSKDNTCRI 415 Query: 263 WR 264 W+ Sbjct: 416 WK 417 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 27/86 (31%), Positives = 47/86 (54%), Gaps = 4/86 (4%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247 GH I L F+ +L+++ S DH RLW+++T V + + GHR EV S ++ Sbjct: 219 GHRAEIVSLGFNT-GGDLIVTGSFDHDSRLWDVRTGQCVHV---LSGHRGEVSSTQFNYA 274 Query: 248 GEKIMSCGMDHSLKLWRINSKRMMNA 273 G ++S +D + +LW + S R ++ Sbjct: 275 GTLVVSGSIDCTSRLWDVRSGRCLSV 300 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 26/85 (30%), Positives = 46/85 (54%), Gaps = 4/85 (4%) Query: 179 TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDE 238 T QC+ GH ++ +F+ L++S S D RLW++++ +++ +GH DE Sbjct: 252 TGQCVHVLSGHRGEVSSTQFN-YAGTLVVSGSIDCTSRLWDVRSGRCLSV---KQGHTDE 307 Query: 239 VLSADYDLLGEKIMSCGMDHSLKLW 263 VL +D G K++S D S +L+ Sbjct: 308 VLDVAFDAAGTKMVSASADGSARLY 332 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 23/87 (26%), Positives = 47/87 (54%), Gaps = 4/87 (4%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247 GH I L F+P+ ++ + S D+ +LW+++T A G HR E++S ++ Sbjct: 177 GHQTEIVCLSFNPQ-STIIATGSMDNTAKLWDVETGQERATLAG---HRAEIVSLGFNTG 232 Query: 248 GEKIMSCGMDHSLKLWRINSKRMMNAI 274 G+ I++ DH +LW + + + ++ + Sbjct: 233 GDLIVTGSFDHDSRLWDVRTGQCVHVL 259 Score = 35.8 bits (81), Expect = 0.034, Method: Compositional matrix adjust. Identities = 21/97 (21%), Positives = 48/97 (49%), Gaps = 3/97 (3%) Query: 173 RIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGV 232 ++ N T + + GH N + + F+ + +++ S D +LW+ T L + + Sbjct: 119 KVWNTFTGEEVFTLEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAYTGQL---YYTL 175 Query: 233 EGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKR 269 +GH+ E++ ++ I + MD++ KLW + + + Sbjct: 176 KGHQTEIVCLSFNPQSTIIATGSMDNTAKLWDVETGQ 212 Score = 29.6 bits (65), Expect = 2.7, Method: Compositional matrix adjust. Identities = 21/103 (20%), Positives = 46/103 (44%), Gaps = 12/103 (11%) Query: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTD----TLVAIFGGVEGHR 236 +C+ GH + + ++ F ++ S S D + RL++ T TLV GH Sbjct: 296 RCLSVKQGHTDEVLDVAFDAAGTKMV-SASADGSARLYHTLTGVCQHTLV-------GHE 347 Query: 237 DEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 279 E+ ++ G ++++ D + +LW ++ + ++ D Sbjct: 348 GEISKVAFNPQGTRLITASSDKTCRLWDCDTGECLQVLEGHTD 390 Score = 29.3 bits (64), Expect = 3.9, Method: Compositional matrix adjust. Identities = 21/87 (24%), Positives = 40/87 (45%), Gaps = 10/87 (11%) Query: 206 LLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYD-LLGEKIMSCGMDHSLKLWR 264 ++ S D ++WN T V +EGH++ V + ++ G+KI++ D + KLW Sbjct: 109 FITGSYDRTCKVWNTFTGEEVFT---LEGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWD 165 Query: 265 INSKRMMNAIKE------SYDYNPNKT 285 + ++ +K +NP T Sbjct: 166 AYTGQLYYTLKGHQTEIVCLSFNPQST 192 >6MZM-G nrPDB Length = 800 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 47/184 (25%), Positives = 88/184 (47%), Gaps = 20/184 (10%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVT-LYECHSQGEIRLLQSYV 139 +F C+ K HN P++ QF+ + F + G +RV L+ +R+ ++ Sbjct: 574 TFTCLVGYK-GHNYPVWDTQFSPYG-----YYFVSGGHDRVARLWATDHYQPLRIFAGHL 627 Query: 140 DADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFH 199 AD N C + N+++ +A + +R+ + + C++ + GH I+ L F Sbjct: 628 ---ADVN---CT-RFHPNSNY--VATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFS 678 Query: 200 PRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHS 259 P + L + + D + LW+I +V G ++GH D V S + GE + S MD++ Sbjct: 679 P-NGRFLATGATDGRVLLWDIGHGLMV---GELKGHTDTVCSLRFSRDGEILASGSMDNT 734 Query: 260 LKLW 263 ++LW Sbjct: 735 VRLW 738 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 61/254 (24%), Positives = 94/254 (37%), Gaps = 52/254 (20%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247 GH + F P D N LLS S+D +RLW++QT T + G +GH V + Sbjct: 541 GHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFTCLV---GYKGHNYPVWDTQFSPY 596 Query: 248 GEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRN 307 G +S G D +LW + Y P R F H D + H N Sbjct: 597 GYYFVSGGHDRVARLWATD------------HYQP---LRIFAG---HLADVNCTRFHPN 638 Query: 308 YVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMR 367 + + + S + + W D+ N + F + I + Sbjct: 639 --------SNYVATGSADRTVRLW-------DV-------LNGNCVRIFTGHKGPIHSLT 676 Query: 368 FSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIA 427 FS + + LA G G++ +WD+ H L H + FSRD IL + Sbjct: 677 FSPN--GRFLATGATDGRVLLWDIG----HGLMVGELKGHT--DTVCSLRFSRDGEILAS 728 Query: 428 VCDDASIWRWDRLR 441 D ++ WD ++ Sbjct: 729 GSMDNTVRLWDAIK 742 Score = 32.7 bits (73), Expect = 0.32, Method: Compositional matrix adjust. Identities = 49/248 (19%), Positives = 91/248 (36%), Gaps = 34/248 (13%) Query: 148 YTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLL 207 Y +++ D N L + G +R+ + T C+ Y GH + + +F P + Sbjct: 547 YGASFSPDRN----YLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYG-YYFV 601 Query: 208 SVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI-- 265 S D RLW + IF GH +V + + + D +++LW + Sbjct: 602 SGGHDRVARLWATDHYQPLRIFA---GHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658 Query: 266 -NSKRMMNAIK---ESYDYNPN--------KTNRPFISQKIHFPDFSTRDIHRNYVDCVR 313 N R+ K S ++PN R + H H + V +R Sbjct: 659 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLR 718 Query: 314 WL--GDLILSKSCENAIVCWKPGKMEDDIDKIK----------PSESNVTILGRFDYSQC 361 + G+++ S S +N + W K +D++ P S +LG + Sbjct: 719 FSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKST 778 Query: 362 DIWYMRFS 369 + ++ F+ Sbjct: 779 PVVHLHFT 786 >1VYH-C nrPDB Length = 410 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 40/182 (21%), Positives = 77/182 (42%), Gaps = 41/182 (22%) Query: 133 RLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNA 192 R L+ + D+ D +F + S LLA + I++ + +CI+ GH + Sbjct: 144 RTLKGHTDSVQDISF---------DHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHN 194 Query: 193 INELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIM 252 ++ + P + + ++S S+D +++W +QT V F GHR+ V + G I Sbjct: 195 VSSVSIMP-NGDHIVSASRDKTIKMWEVQTGYCVKTF---TGHREWVRMVRPNQDGTLIA 250 Query: 253 SCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCV 312 SC D ++++W + +K ++E HR+ V+C+ Sbjct: 251 SCSNDQTVRVWVVATKECKAELRE----------------------------HRHVVECI 282 Query: 313 RW 314 W Sbjct: 283 SW 284 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 37/156 (23%), Positives = 65/156 (41%), Gaps = 24/156 (15%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247 GH + + + FHP ++++S S+D +++W+ +T ++GH D V +D Sbjct: 106 GHRSPVTRVIFHPV-FSVMVSASEDATIKVWDYETGDFERT---LKGHTDSVQDISFDHS 161 Query: 248 GEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS------- 300 G+ + SC D ++KLW I+ + ++ N ++ + H S Sbjct: 162 GKLLASCSADMTIKLWDFQG---FECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIKM 218 Query: 301 ----------TRDIHRNYVDCVRWLGDLILSKSCEN 326 T HR +V VR D L SC N Sbjct: 219 WEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSN 254 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 26/111 (23%), Positives = 46/111 (41%), Gaps = 4/111 (3%) Query: 153 TYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKD 212 T S P L I++ + T C+ VGH N + + FH +LS + D Sbjct: 301 TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHS-GGKFILSCADD 359 Query: 213 HALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLW 263 LR+W+ + + H V S D+ +++ +D ++K+W Sbjct: 360 KTLRVWDYKNKRCMKTLN---AHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 20/70 (28%), Positives = 37/70 (52%), Gaps = 3/70 (4%) Query: 205 LLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 LLS S+D +++W++ T + + GH + V + G+ I+SC D +L++W Sbjct: 310 FLLSGSRDKTIKMWDVSTGMCLMT---LVGHDNWVRGVLFHSGGKFILSCADDKTLRVWD 366 Query: 265 INSKRMMNAI 274 +KR M + Sbjct: 367 YKNKRCMKTL 376 >2H9P-A nrPDB Length = 329 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 36/132 (27%), Positives = 66/132 (50%), Gaps = 10/132 (7%) Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS 210 AW+ DSN LL A ++I + + +C+K GH N + F+P+ NL++S S Sbjct: 89 AWSSDSN----LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGS 143 Query: 211 KDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRM 270 D ++R+W+++T + + H D V + ++ G I+S D ++W S + Sbjct: 144 FDESVRIWDVKTGKCLKT---LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 200 Query: 271 MNAIKESYDYNP 282 + + + D NP Sbjct: 201 LKTLID--DDNP 210 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 26/117 (22%), Positives = 57/117 (48%), Gaps = 4/117 (3%) Query: 163 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQT 222 LA + + +I+I + K GH I+++ + D NLL+S S D L++W++ + Sbjct: 55 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW-SSDSNLLVSASDDKTLKIWDVSS 113 Query: 223 DTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 279 + ++GH + V +++ I+S D S+++W + + + + + D Sbjct: 114 GKCLKT---LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD 167 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 45/186 (24%), Positives = 83/186 (44%), Gaps = 20/186 (10%) Query: 83 KCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDAD 142 KC+ +L H+ P+ V FN ++G +V S+ L + L++ +D Sbjct: 157 KCLKTLPA-HSDPVSAVHFN---RDGSLIV----SSSYDGLCRIWDTASGQCLKTLID-- 206 Query: 143 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINEL--KFHP 200 D+N + N + L A + +++ + +C+K Y GH N + F Sbjct: 207 -DDNPPVSFVKFSPNGKYILAATLDNT--LKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 263 Query: 201 RDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGM--DH 258 ++S S+D+ + +WN+QT +V ++GH D V+S I S + D Sbjct: 264 TGGKWIVSGSEDNLVYIWNLQTKEIVQ---KLQGHTDVVISTACHPTENIIASAALENDK 320 Query: 259 SLKLWR 264 ++KLW+ Sbjct: 321 TIKLWK 326 Score = 37.7 bits (86), Expect = 0.011, Method: Compositional matrix adjust. Identities = 26/95 (27%), Positives = 45/95 (47%), Gaps = 6/95 (6%) Query: 187 VGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVE-GHRDEVLSADYD 245 GH A++ +KF P + L S S D +++W G + G D S+D + Sbjct: 37 AGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 95 Query: 246 LLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDY 280 LL +S D +LK+W ++S + + +K +Y Sbjct: 96 LL----VSASDDKTLKIWDVSSGKCLKTLKGHSNY 126 Score = 34.3 bits (77), Expect = 0.10, Method: Compositional matrix adjust. Identities = 34/140 (24%), Positives = 67/140 (47%), Gaps = 13/140 (9%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 140 S +C+ +L +D N P+ V+F S G ++ AT+ N + L++ +S+G + L++Y Sbjct: 197 SGQCLKTLIDDDNPPVSFVKF---SPNGKYILAATL-DNTLKLWD-YSKG--KCLKTYT- 248 Query: 141 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP 200 +N C + S T + ++ I N T + ++ GH + + HP Sbjct: 249 --GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 306 Query: 201 RDPNLLLSVS--KDHALRLW 218 + N++ S + D ++LW Sbjct: 307 TE-NIIASAALENDKTIKLW 325 >5OPT-p nrPDB Length = 318 Score = 51.2 bits (121), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 35/119 (29%), Positives = 60/119 (50%), Gaps = 5/119 (4%) Query: 172 IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGG 231 +R+ N T C ++GH + + F P D ++S +D+ALR+WN++ + L + G Sbjct: 91 LRLWNLQTGVCQHKFLGHTKDVLSVTFSP-DNRQIVSGGRDNALRVWNVKGECLHTL--G 147 Query: 232 VEGHRDEVLSADY--DLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRP 288 H D V + L I+S G D+ +K+W I S R++ +K +Y + T P Sbjct: 148 RGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSP 206 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 56/238 (23%), Positives = 92/238 (38%), Gaps = 62/238 (26%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247 GH ++++ + + +S S DH+LRLWN+QT F GH +VLS + Sbjct: 65 GHSAFVSDVAL-SNNGDFAVSASWDHSLRLWNLQTGVCQHKF---LGHTKDVLSVTFSPD 120 Query: 248 GEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRN 307 +I+S G D++L++W + + + R H + Sbjct: 121 NRQIVSGGRDNALRVWNVKGECLHTL---------------------------GRGAHTD 153 Query: 308 YVDCVRWLGD----LILSKSCENAIVCW--KPGKMEDDIDKIKPSESNVTILGRFDYSQC 361 +V CVR+ LI+S +N + W G++ D+ ++VT+ D S C Sbjct: 154 WVSCVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTV--SPDGSLC 211 Query: 362 DIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFS 419 A ++ G +WDL K L+ GA I Q FS Sbjct: 212 ----------------ASSDKDGVARLWDL-------TKGEALSEMAAGAPINQICFS 246 >5M25-A nrPDB Length = 434 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 36/132 (27%), Positives = 66/132 (50%), Gaps = 10/132 (7%) Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS 210 AW+ DSN LL A ++I + + +C+K GH N + F+P+ NL++S S Sbjct: 194 AWSSDSN----LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGS 248 Query: 211 KDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRM 270 D ++R+W+++T + + H D V + ++ G I+S D ++W S + Sbjct: 249 FDESVRIWDVKTGKCLKT---LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 305 Query: 271 MNAIKESYDYNP 282 + + + D NP Sbjct: 306 LKTLID--DDNP 315 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 26/117 (22%), Positives = 57/117 (48%), Gaps = 4/117 (3%) Query: 163 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQT 222 LA + + +I+I + K GH I+++ + D NLL+S S D L++W++ + Sbjct: 160 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS-SDSNLLVSASDDKTLKIWDVSS 218 Query: 223 DTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 279 + ++GH + V +++ I+S D S+++W + + + + + D Sbjct: 219 GKCLKT---LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD 272 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 45/186 (24%), Positives = 83/186 (44%), Gaps = 20/186 (10%) Query: 83 KCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDAD 142 KC+ +L H+ P+ V FN ++G +V S+ L + L++ +D Sbjct: 262 KCLKTLPA-HSDPVSAVHFN---RDGSLIV----SSSYDGLCRIWDTASGQCLKTLID-- 311 Query: 143 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINEL--KFHP 200 D+N + N + L A + +++ + +C+K Y GH N + F Sbjct: 312 -DDNPPVSFVKFSPNGKYILAATLDN--TLKLWDYSKGKCLKTYTGHKNEKYCIFANFSV 368 Query: 201 RDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGM--DH 258 ++S S+D+ + +WN+QT +V ++GH D V+S I S + D Sbjct: 369 TGGKWIVSGSEDNLVYIWNLQTKEIVQ---KLQGHTDVVISTACHPTENIIASAALENDK 425 Query: 259 SLKLWR 264 ++KLW+ Sbjct: 426 TIKLWK 431 Score = 37.0 bits (84), Expect = 0.015, Method: Compositional matrix adjust. Identities = 26/95 (27%), Positives = 45/95 (47%), Gaps = 6/95 (6%) Query: 187 VGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVE-GHRDEVLSADYD 245 GH A++ +KF P + L S S D +++W G + G D S+D + Sbjct: 142 AGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 200 Query: 246 LLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDY 280 LL +S D +LK+W ++S + + +K +Y Sbjct: 201 LL----VSASDDKTLKIWDVSSGKCLKTLKGHSNY 231 Score = 34.7 bits (78), Expect = 0.083, Method: Compositional matrix adjust. Identities = 32/140 (22%), Positives = 65/140 (46%), Gaps = 13/140 (9%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 140 S +C+ +L +D N P+ V+F+ + K + A N + L++ +S+G + L++Y Sbjct: 302 SGQCLKTLIDDDNPPVSFVKFSPNGK----YILAATLDNTLKLWD-YSKG--KCLKTYT- 353 Query: 141 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP 200 +N C + S T + ++ I N T + ++ GH + + HP Sbjct: 354 --GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 411 Query: 201 RDPNLLLSVS--KDHALRLW 218 + N++ S + D ++LW Sbjct: 412 TE-NIIASAALENDKTIKLW 430 >3JB9-g nrPDB Length = 558 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 42/168 (25%), Positives = 76/168 (45%), Gaps = 26/168 (15%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTD-TLVAIFGGVEGHRDEVLSADYDL 246 GH I+ L+F P +LLLS S D+ +++W + D +L+ F +GH + + Sbjct: 264 GHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDRSLLRTF---QGHARPIRDLSFSQ 320 Query: 247 LGEKIMSCGMDHSLKLWR---------INSKRMMNAIKESYDYNPNKTN--------RPF 289 G +S D ++KLW NS R+ N +K + +P+K N + Sbjct: 321 DGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVK--FQVDPDKPNEFLAGTADKRI 378 Query: 290 ISQKIHFPDF-STRDIHRNYVDCVRWL--GDLILSKSCENAIVCWKPG 334 + I PD D H ++ + +L G ++ S ++++ W+ G Sbjct: 379 LQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYG 426 >5XYI-g nrPDB Length = 335 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 26/79 (32%), Positives = 45/79 (56%), Gaps = 4/79 (5%) Query: 187 VGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDL 246 +GH + ++++ RD + LL+ S D LRLW++ T T +F GH+ +VL + Sbjct: 77 IGHNHFVSDVSL-SRDASHLLTSSWDSTLRLWDLSTRTTKKLF---LGHKKDVLGVTFSP 132 Query: 247 LGEKIMSCGMDHSLKLWRI 265 +I+S G D+ +K+W I Sbjct: 133 CNRRIISVGRDNQVKIWNI 151 >5FL8-q nrPDB Length = 515 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 26/81 (32%), Positives = 48/81 (59%), Gaps = 4/81 (4%) Query: 183 IKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSA 242 I + GH ++ ++ + D LL+S SKD L++W+++T L + GH+DEV + Sbjct: 437 ISTFRGHVASVYQVAWS-SDCRLLVSCSKDTTLKVWDVRTRKLSV---DLPGHKDEVYTV 492 Query: 243 DYDLLGEKIMSCGMDHSLKLW 263 D+ + G+++ S G D ++LW Sbjct: 493 DWSVDGKRVCSGGKDKMVRLW 513 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 50/231 (21%), Positives = 95/231 (41%), Gaps = 28/231 (12%) Query: 124 YECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCI 183 + C QG+ + D +N Y+ N++ + + + + + P+T + Sbjct: 79 FSCTIQGK-KASDPVKTIDITDNLYSSLIKPGYNSTEDQITLLYTPRAVFKVKPVT-RSS 136 Query: 184 KHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSAD 243 GHG+ I F P + +++ + D+ R+W+ T T + +GH + VL Sbjct: 137 SAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHTL---KGHYNWVLCVS 193 Query: 244 YDLLGEKIMSCGMDHSLKLWRINSKRMM-NAIK------ESYDYNPNKTNRPFISQK--- 293 + GE I + MD++++LW S + + +A++ S + P +P + Sbjct: 194 WSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLAS 253 Query: 294 ------IHFPDFSTR------DIHRNYVDCVRWLGD-LILSKSCENAIVCW 331 I D +R H N V CV+W G L+ S S + + W Sbjct: 254 SSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQGLLYSGSHDRTVRVW 304 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 26/113 (23%), Positives = 55/113 (48%), Gaps = 5/113 (4%) Query: 159 SHPLLAVAGSRGIIRIINPI-TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRL 217 S ++ A + + NP+ + + I GH +N + F P D ++S S D++++L Sbjct: 370 SEEMMVTASDDYTMFLWNPLKSTKPIARMTGHQKLVNHVAFSP-DGRYIVSASFDNSIKL 428 Query: 218 WNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRM 270 W+ + ++ F GH V + ++SC D +LK+W + ++++ Sbjct: 429 WDGRDGKFISTF---RGHVASVYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKL 478 >4V8M-A7 nrPDB Length = 318 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 57/238 (23%), Positives = 92/238 (38%), Gaps = 62/238 (26%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247 GH ++++ + N +S S DH+LRLWN+Q F GH +VLS + Sbjct: 65 GHSAFVSDVALS-NNGNFAVSASWDHSLRLWNLQNGQCQYKF---LGHTKDVLSVAFSPD 120 Query: 248 GEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRN 307 +I+S G D++L++W + + M +R H + Sbjct: 121 NRQIVSGGRDNALRVWNVKGECMHTL---------------------------SRGAHTD 153 Query: 308 YVDCVRWLGDL----ILSKSCENAIVCW--KPGKMEDDIDKIKPSESNVTILGRFDYSQC 361 +V CVR+ L I+S +N + W G++ D+ ++VT+ D S C Sbjct: 154 WVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTV--SPDGSLC 211 Query: 362 DIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFS 419 A ++ G +WDL K L+ GA I Q FS Sbjct: 212 ----------------ASSDKDGVARLWDL-------TKGEALSEMAAGAPINQICFS 246 >6J6H-n nrPDB Length = 455 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 51/280 (18%), Positives = 109/280 (38%), Gaps = 37/280 (13%) Query: 178 ITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRD 237 + + I++Y GH LKF P+ +L+LS DH +++W+ D +GH Sbjct: 150 LPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD--YECLRDFQGHNK 207 Query: 238 EVLSADYDLLGEKIMSCGMDHSLKLW-----RINSKRMMNAIKESYDYNPNKTNRPFI-- 290 + + + + +S D S+K+W ++ ++ +N+ + P + + Sbjct: 208 PIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGL 267 Query: 291 --SQKIHFPD--------FSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWKPGKMED 338 S+ +H+ D T D H + + +++ G +S S + + W+ Sbjct: 268 SNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE------ 321 Query: 339 DIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHK 398 ++ NV I D +Q + ++ Q + ++Y + L+ + Sbjct: 322 -------NQINVPIKQISDTAQHSMPFLNVHPS--QNYFCAQSMDNRIYSFSLKPKYKRH 372 Query: 399 AKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 K H G I +FS D + + + ++ WD Sbjct: 373 PKKIFKGHSSAGYGI-SLAFSGDGRYICSGDSKSRLFTWD 411 >5OQL-X nrPDB Length = 630 Score = 48.1 bits (113), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 36/125 (28%), Positives = 61/125 (48%), Gaps = 18/125 (14%) Query: 153 TYDSNTSHPLLAVA----------GSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRD 202 TY + PL+ A G+ + + N ++ IK + H +A+ L F R Sbjct: 241 TYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFR-RG 299 Query: 203 PNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLG-EKIMSCGM-DHSL 260 N L S SKD +++W++ +A + GH+DE+L D D LG E+ +S G D + Sbjct: 300 TNQLYSCSKDRTVKVWSLDE---LAYVETLFGHQDEIL--DIDALGQERCVSVGARDRTA 354 Query: 261 KLWRI 265 + W++ Sbjct: 355 RYWKV 359 >6QX9-5O nrPDB Length = 357 Score = 48.1 bits (113), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 57/285 (20%), Positives = 109/285 (38%), Gaps = 56/285 (19%) Query: 157 NTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALR 216 NT +L A + + + + T + +K GH + +N R P L+ + S D ++ Sbjct: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVK 177 Query: 217 LWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE 276 LW+I+ + F +VL+ ++ ++I+S G+D+ +K+W + ++ + Sbjct: 178 LWDIRKKAAIQTFQNTY----QVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTM-- 231 Query: 277 SYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL-----GDLILSKSCENAIVCW 331 R + D V L G +LS + +N + W Sbjct: 232 -----------------------------RGHADSVTGLSLSSEGSYLLSNAMDNTVRVW 262 Query: 332 KPGKMEDDIDKIKPSESNVTIL-GRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWD 390 D+ P E V I G + ++ +S D +A G+ +YVWD Sbjct: 263 -------DVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD--GSKIAAGSADRFVYVWD 313 Query: 391 LEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIW 435 + L H +I + +F D I+I+ D ++ Sbjct: 314 TT----SRRILYKLPGH--AGSINEVAFHPDEPIIISASSDKRLY 352 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 22/90 (24%), Positives = 46/90 (51%), Gaps = 6/90 (6%) Query: 132 IRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGN 191 +++ Q V + ++N C+W+ D + +A + + + + + + + GH Sbjct: 274 VKIFQGNVH-NFEKNLLRCSWSPDGSK----IAAGSADRFVYVWDTTSRRILYKLPGHAG 328 Query: 192 AINELKFHPRDPNLLLSVSKDHALRLWNIQ 221 +INE+ FHP +P +++S S D L + IQ Sbjct: 329 SINEVAFHPDEP-IIISASSDKRLYMGEIQ 357 Score = 36.2 bits (82), Expect = 0.029, Method: Compositional matrix adjust. Identities = 21/76 (27%), Positives = 35/76 (46%), Gaps = 3/76 (3%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247 GH + KFHP + + L S D + LWN+ D + ++GH V+ Y+ Sbjct: 64 GHEGEVYCCKFHP-NGSTLASAGFDRLILLWNVYGD--CDNYATLKGHSGAVMELHYNTD 120 Query: 248 GEKIMSCGMDHSLKLW 263 G + S D ++ +W Sbjct: 121 GSMLFSASTDKTVAVW 136 >3JAP-g nrPDB Length = 326 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 35/114 (30%), Positives = 54/114 (47%), Gaps = 10/114 (8%) Query: 156 SNTSHPLLAVAGSRGIIRIINPITMQ------CIKHYVGHGNAINELKFHPRDPNLLLSV 209 ++ + P L V+GSR I +T ++ Y GH + + ++ D N +S Sbjct: 26 TSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDVVVSA-DGNYAVSA 84 Query: 210 SKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLW 263 S D LRLWN+ T A F GH +VLS D KI+S D ++++W Sbjct: 85 SWDKTLRLWNLATGNSEARF---VGHTGDVLSVAIDANSSKIISASRDKTIRVW 135 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 27/86 (31%), Positives = 39/86 (45%), Gaps = 14/86 (16%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFG----GVEGH----RDEV 239 GH + L PNLL+S S+D L W + + FG +GH +D V Sbjct: 16 GHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENE--QQFGVPVRSYKGHSHIVQDVV 73 Query: 240 LSADYDLLGEKIMSCGMDHSLKLWRI 265 +SAD G +S D +L+LW + Sbjct: 74 VSAD----GNYAVSASWDKTLRLWNL 95 Score = 29.6 bits (65), Expect = 3.0, Method: Compositional matrix adjust. Identities = 25/105 (23%), Positives = 46/105 (43%), Gaps = 15/105 (14%) Query: 172 IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGG 231 +R+ N T +VGH + + + + ++S S+D +R+WN D + Sbjct: 90 LRLWNLATGNSEARFVGHTGDVLSVAIDA-NSSKIISASRDKTIRVWNTVGDCAYVLL-- 146 Query: 232 VEGHRD---EVLSADYDLLGEKI-------MSCGMDHSLKLWRIN 266 GH D +V A +L ++ +S GMD ++ W +N Sbjct: 147 --GHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLN 189 >4BTS-AR nrPDB Length = 343 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 55/239 (23%), Positives = 98/239 (41%), Gaps = 47/239 (19%) Query: 184 KHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSAD 243 K GH + +++L ++ +S S D LRLW+++T T F GH+ EV S Sbjct: 70 KALTGHNHFVSDLAL-SQENCFAISSSWDKTLRLWDLRTGTTYKRF---VGHQSEVYSVA 125 Query: 244 YDLLGEKIMSCGMDHSLKLWRINSK-RMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTR 302 + +I+S G + +KLW I + + +A KE+ Sbjct: 126 FSPDNRQILSAGAEREIKLWNILGECKFSSAEKEN------------------------- 160 Query: 303 DIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDID-KIKPSESNVTILGRFDYSQC 361 H ++V CVR+ + N + + P D ++K +N I F + Sbjct: 161 --HSDWVSCVRYSPIM----KSANKVQPFAPYFASVGWDGRLKVWNTNFQIRYTFKAHES 214 Query: 362 DIWYMRFSMDFWQKMLALGNQVGKLYVWD-LEVEDPHKAKCTTLTHHKCGAAIRQTSFS 419 ++ ++ S + K +A G + KL +WD L + P + G+ I Q +F+ Sbjct: 215 NVNHLSISPN--GKYIATGGKDKKLLIWDILNLTYPQR-------EFDAGSTINQIAFN 264 >3FM0-A nrPDB Length = 345 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 24/84 (28%), Positives = 42/84 (50%), Gaps = 2/84 (2%) Query: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 240 +C+ H + + +HP LL S S D ++L+ + D V +EGH V Sbjct: 141 ECVSVLNSHTQDVKHVVWHPSQ-ELLASASYDDTVKLYREEEDDWVCC-ATLEGHESTVW 198 Query: 241 SADYDLLGEKIMSCGMDHSLKLWR 264 S +D G+++ SC D ++++WR Sbjct: 199 SLAFDPSGQRLASCSDDRTVRIWR 222 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 37/138 (26%), Positives = 56/138 (40%), Gaps = 9/138 (6%) Query: 134 LLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYV---GHG 190 +L V A D + AW N + LLA G IRI I V GH Sbjct: 6 VLLGRVPAHPDSRCWFLAW----NPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQ 61 Query: 191 NAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEK 250 + ++ + P N L S S D +W D + +EGH +EV S + G Sbjct: 62 RTVRKVAWSPCG-NYLASASFDATTCIWKKNQDDFECVTT-LEGHENEVKSVAWAPSGNL 119 Query: 251 IMSCGMDHSLKLWRINSK 268 + +C D S+ +W ++ + Sbjct: 120 LATCSRDKSVWVWEVDEE 137 Score = 35.0 bits (79), Expect = 0.068, Method: Compositional matrix adjust. Identities = 19/85 (22%), Positives = 38/85 (44%), Gaps = 1/85 (1%) Query: 180 MQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEV 239 +C+ GH N + + + P NLL + S+D ++ +W + + + H +V Sbjct: 95 FECVTTLEGHENEVKSVAWAPSG-NLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDV 153 Query: 240 LSADYDLLGEKIMSCGMDHSLKLWR 264 + E + S D ++KL+R Sbjct: 154 KHVVWHPSQELLASASYDDTVKLYR 178 Score = 29.6 bits (65), Expect = 2.8, Method: Compositional matrix adjust. Identities = 11/34 (32%), Positives = 18/34 (52%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221 H +N + ++P++P LL S S D + W Q Sbjct: 301 AHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334 >6HQA-B nrPDB Length = 722 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 26/86 (30%), Positives = 45/86 (52%), Gaps = 5/86 (5%) Query: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGH-RDEV 239 +C++ ++GH AIN L P D L S +D + LW+I T + + GH R + Sbjct: 570 ECVRVFMGHSGAINCLAVSP-DGRWLASAGEDSVVCLWDISTGRRIK---AMRGHGRSSI 625 Query: 240 LSADYDLLGEKIMSCGMDHSLKLWRI 265 S + G ++S G D+S+++W + Sbjct: 626 YSLAFSREGTVLVSTGADNSVRVWDV 651 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 23/86 (26%), Positives = 42/86 (48%), Gaps = 4/86 (4%) Query: 178 ITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRD 237 + ++ + VGH A+ + F P D L+S S+D +RLW++ T T + + +GH Sbjct: 441 VAVKGSRRLVGHSGAVYGVDFSP-DNRYLISCSEDKTVRLWSLDTYTCLVSY---KGHSS 496 Query: 238 EVLSADYDLLGEKIMSCGMDHSLKLW 263 V + +G + D + +LW Sbjct: 497 SVWDVKFSPMGHYFATASHDQTARLW 522 Score = 34.7 bits (78), Expect = 0.088, Method: Compositional matrix adjust. Identities = 22/94 (23%), Positives = 44/94 (46%), Gaps = 4/94 (4%) Query: 172 IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGG 231 +R+ + T C+ Y GH +++ ++KF P + + S D RLW+ + IF Sbjct: 477 VRLWSLDTYTCLVSYKGHSSSVWDVKFSPMG-HYFATASHDQTARLWSCDHIYPLRIFA- 534 Query: 232 VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI 265 GH ++V ++ + + D + ++W I Sbjct: 535 --GHLNDVDCVEFHPNSTYLFTGSSDKTARMWDI 566 Score = 33.1 bits (74), Expect = 0.26, Method: Compositional matrix adjust. Identities = 20/63 (31%), Positives = 38/63 (60%), Gaps = 2/63 (3%) Query: 163 LAVAGSRGIIRIINPITMQCIKHYVGHG-NAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221 LA AG ++ + + T + IK GHG ++I L F R+ +L+S D+++R+W+++ Sbjct: 594 LASAGEDSVVCLWDISTGRRIKAMRGHGRSSIYSLAFS-REGTVLVSTGADNSVRVWDVK 652 Query: 222 TDT 224 +T Sbjct: 653 KNT 655 Score = 31.2 bits (69), Expect = 0.93, Method: Compositional matrix adjust. Identities = 24/104 (23%), Positives = 46/104 (44%), Gaps = 19/104 (18%) Query: 182 CIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI----------------QTDTL 225 C+ + N + LKF+ D ++ S +D ++LW+I Q + Sbjct: 382 CMYTFHNTNNDLTCLKFN-DDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQQNNDG 440 Query: 226 VAIFGG--VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 267 VA+ G + GH V D+ ++SC D +++LW +++ Sbjct: 441 VAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDT 484 >4V6W-Ag nrPDB Length = 318 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 37/157 (23%), Positives = 67/157 (42%), Gaps = 26/157 (16%) Query: 179 TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV-------AIFGG 231 T+Q +GH + ++ +P+DP+ ++S S+D L +W + D ++G Sbjct: 4 TLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGH 63 Query: 232 VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI----NSKRMMNAIKESYDYNPNKTNR 287 D VLS+D G +S D +L+LW + ++R K+ + NR Sbjct: 64 SHFISDVVLSSD----GNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNR 119 Query: 288 PFIS----------QKIHFPDFSTR-DIHRNYVDCVR 313 +S + F+ + D H ++V CVR Sbjct: 120 QIVSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVR 156 Score = 35.0 bits (79), Expect = 0.064, Method: Compositional matrix adjust. Identities = 27/112 (24%), Positives = 54/112 (48%), Gaps = 6/112 (5%) Query: 164 AVAGS-RGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQT 222 A++GS +R+ + + + + GH + + F D ++S S+D ++LWN Sbjct: 79 ALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSA-DNRQIVSGSRDKTIKLWNTLA 137 Query: 223 DTLVAIFGGVEGHRDEVLSADY--DLLGEKIMSCGMDHSLKLWRINSKRMMN 272 + I +GH D V + + I+SCG D ++K+W + + ++ N Sbjct: 138 ECKFTI--QEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKN 187 Score = 29.3 bits (64), Expect = 3.6, Method: Compositional matrix adjust. Identities = 26/131 (19%), Positives = 55/131 (41%), Gaps = 11/131 (8%) Query: 90 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYT 149 E H + + V F+ +++ GS T+ ++ E + + D ++ + Sbjct: 103 EGHTKDVLSVAFSADNRQ------IVSGSRDKTIKLWNTLAECKFT---IQEDGHTDWVS 153 Query: 150 CAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSV 209 C + N S+P++ G +++ N + ++ GH +N + P D +L S Sbjct: 154 CV-RFSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNHHGHNGYLNTVTVSP-DGSLCTSG 211 Query: 210 SKDHALRLWNI 220 KD LW++ Sbjct: 212 GKDSKALLWDL 222 >5K1B-B nrPDB Length = 677 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 55/238 (23%), Positives = 94/238 (39%), Gaps = 42/238 (17%) Query: 206 LLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI 265 L+S S D +++WN ++ H+D V + Y E + S G+D + LW + Sbjct: 90 LISASSDTTVKVWNAHKGFCMSTL---RTHKDYVKALAYAKDKELVASAGLDRQIFLWDV 146 Query: 266 NSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCE 325 N+ + A + + N+ I Y + LG +I+S S E Sbjct: 147 NTLTALTASNNTVTTSSLSGNKDSI-----------------YSLAMNQLGTIIVSGSTE 189 Query: 326 NAIVCWKPGKMEDDIDKIKPSESNV-TILGRFDYSQCDIWYMRFSMDFWQKMLALGNQ-- 382 + W P + + K+K NV +L D +QC + S D ++ +LG Q Sbjct: 190 KVLRVWDP-RTCAKLMKLKGHTDNVKALLLNRDGTQC----LSGSSDGTIRLWSLGQQRC 244 Query: 383 -----VGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFS--RDSSILIAVCDDAS 433 V VW L+V D TH G R+ + R+ I + +C++ + Sbjct: 245 IATYRVHDEGVWALQVND-------AFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKA 295 Score = 30.0 bits (66), Expect = 1.9, Method: Compositional matrix adjust. Identities = 19/68 (27%), Positives = 34/68 (50%), Gaps = 2/68 (2%) Query: 163 LAVAGS-RGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221 + V+GS ++R+ +P T + GH + + L + RD LS S D +RLW++ Sbjct: 182 IIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLN-RDGTQCLSGSSDGTIRLWSLG 240 Query: 222 TDTLVAIF 229 +A + Sbjct: 241 QQRCIATY 248 >3DM0-A nrPDB Length = 694 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 31/121 (25%), Positives = 59/121 (48%), Gaps = 4/121 (3%) Query: 163 LAVAGS-RGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221 A++GS G +R+ + + +VGH + + F D ++S S+D ++LWN Sbjct: 444 FALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFS-LDNRQIVSASRDRTIKLWNTL 502 Query: 222 TDTLVAIFGGVEGHRDEVLSADY--DLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 279 + I G EGHRD V + + L I+S D ++K+W +++ ++ + + Sbjct: 503 GECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLRSTLAGHTG 562 Query: 280 Y 280 Y Sbjct: 563 Y 563 Score = 33.1 bits (74), Expect = 0.22, Method: Compositional matrix adjust. Identities = 37/172 (21%), Positives = 72/172 (41%), Gaps = 35/172 (20%) Query: 189 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVE----GH----RDEVL 240 H + + + + ++++S S+D ++ LW + D +G + GH D VL Sbjct: 381 HTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDD--KAYGVAQRRLTGHSHFVEDVVL 438 Query: 241 SADYDLLGEKIMSCGMDHSLKLW----RINSKRMMNAIKESYDYNPNKTNRPFISQ---- 292 S+D G+ +S D L+LW ++++R + K+ + NR +S Sbjct: 439 SSD----GQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASRDR 494 Query: 293 ---------KIHFPDFSTRDIHRNYVDCVRW----LGDLILSKSCENAIVCW 331 + + + HR++V CVR+ L I+S S + + W Sbjct: 495 TIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVW 546 >6ID0-T nrPDB Length = 514 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 23/83 (27%), Positives = 44/83 (53%), Gaps = 4/83 (4%) Query: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 240 + I+HY GH +A+ L HP ++L++ S+D R+W+++T V GH + V Sbjct: 279 KVIRHYHGHLSAVYGLDLHPTI-DVLVTCSRDSTARIWDVRTKASVHTL---SGHTNAVA 334 Query: 241 SADYDLLGEKIMSCGMDHSLKLW 263 + +I++ D +++LW Sbjct: 335 TVRCQAAEPQIITGSHDTTIRLW 357 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 16/87 (18%), Positives = 41/87 (47%), Gaps = 4/87 (4%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247 GH + + + R P L S +D ++ W+++ + ++ + GH V D Sbjct: 244 GHISTVRGVIVSTRSP-YLFSCGEDKQVKCWDLEYNKVIRHY---HGHLSAVYGLDLHPT 299 Query: 248 GEKIMSCGMDHSLKLWRINSKRMMNAI 274 + +++C D + ++W + +K ++ + Sbjct: 300 IDVLVTCSRDSTARIWDVRTKASVHTL 326 >5Y88-O nrPDB Length = 451 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 25/115 (21%), Positives = 54/115 (46%), Gaps = 4/115 (3%) Query: 160 HPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWN 219 HP L ++ + Q I+ Y GH + + + HP +L+ + +D ++LW+ Sbjct: 194 HPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHP-TLDLIATAGRDSVIKLWD 252 Query: 220 IQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAI 274 ++T V G +G ++V D +++S D +++LW + + + M + Sbjct: 253 MRTRIPVITLVGHKGPINQVQCTPVD---PQVVSSSTDATVRLWDVVAGKTMKVL 304 Score = 34.7 bits (78), Expect = 0.080, Method: Compositional matrix adjust. Identities = 21/82 (25%), Positives = 41/82 (50%), Gaps = 6/82 (7%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVA-IFGGVEGHRDEVLSADYDL 246 GH + ++ R P L SVS+D ++ W+++ + ++ +G + G R + DL Sbjct: 180 GHVMTVRDVAVSDRHP-YLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDL 238 Query: 247 LGEKIMSCGMDHSLKLWRINSK 268 I + G D +KLW + ++ Sbjct: 239 ----IATAGRDSVIKLWDMRTR 256 Score = 31.2 bits (69), Expect = 0.97, Method: Compositional matrix adjust. Identities = 21/65 (32%), Positives = 35/65 (53%), Gaps = 8/65 (12%) Query: 228 IFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKES---YDYNPNK 284 + G +EG R VL + +D G ++++ D S+K+W K+ A KES +NPN Sbjct: 392 MVGSLEGER-SVLCSTFDKTGLRLITGEADKSIKIW----KQDETATKESEPGLAWNPNL 446 Query: 285 TNRPF 289 + + F Sbjct: 447 SAKRF 451 >2YNP-A nrPDB Length = 604 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 39/159 (24%), Positives = 69/159 (43%), Gaps = 15/159 (9%) Query: 109 DPLVFATVGSNRVTLYECHSQGEIRLLQ-SYVDADADENFYTCAWTYDSNTSHPLLAVAG 167 +P V T+ S RV L+ +Q E+R +Q + A + W + V Sbjct: 25 EPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARKNW----------IIVGS 74 Query: 168 SRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVA 227 IR+ N T + + + H + I + HP P +LS S D ++LWN + + A Sbjct: 75 DDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKP-YVLSGSDDLTVKLWNWENNW--A 131 Query: 228 IFGGVEGHRDEVLSADYDLLGEKIMSCG-MDHSLKLWRI 265 + EGH V+ ++ + G +D ++K+W + Sbjct: 132 LEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSL 170 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 22/84 (26%), Positives = 43/84 (51%), Gaps = 4/84 (4%) Query: 188 GHGNAINELKFHPR-DPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDL 246 G +N + ++P D +++ S D +++W+ QT + VA +EGH V A + Sbjct: 182 GQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVAT---LEGHMSNVSFAVFHP 238 Query: 247 LGEKIMSCGMDHSLKLWRINSKRM 270 I+S D +LK+W ++ ++ Sbjct: 239 TLPIIISGSEDGTLKIWNSSTYKV 262 Score = 35.4 bits (80), Expect = 0.045, Method: Compositional matrix adjust. Identities = 19/62 (30%), Positives = 32/62 (51%), Gaps = 1/62 (1%) Query: 161 PLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI 220 P + A I+I + T C+ GH + ++ FHP P +++S S+D L++WN Sbjct: 199 PYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLP-IIISGSEDGTLKIWNS 257 Query: 221 QT 222 T Sbjct: 258 ST 259 Score = 32.0 bits (71), Expect = 0.56, Method: Compositional matrix adjust. Identities = 21/94 (22%), Positives = 45/94 (47%), Gaps = 4/94 (4%) Query: 184 KHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSAD 243 + + GH + + + F+P+DP+ S D +++W++ T F G V D Sbjct: 134 QTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQST--PNFTLTTGQERGVNYVD 191 Query: 244 YDLLGEK--IMSCGMDHSLKLWRINSKRMMNAIK 275 Y L +K +++ D ++K+W +K + ++ Sbjct: 192 YYPLPDKPYMITASDDLTIKIWDYQTKSCVATLE 225 >6HHQ-h nrPDB Length = 319 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 33/134 (24%), Positives = 61/134 (45%), Gaps = 17/134 (12%) Query: 163 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPR-----DPNLLLSVSKDHALRL 217 + ++GSR + I QC+ +GH + +++++ P D ++S D ++ Sbjct: 121 MIISGSRDKTIKVWTIKGQCLATLLGHNDWVSQVRVVPNEKADDDSVTIISAGNDKMVKA 180 Query: 218 WNIQTDTLVAIFGGVEGHRDEV--LSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK 275 WN+ + A F GH + L+A D G I S G D + LW + +K+ M + Sbjct: 181 WNLNQFQIEADF---IGHNSNINTLTASPD--GTLIASAGKDGEIMLWNLAAKKAMYTLS 235 Query: 276 E-----SYDYNPNK 284 S ++PN+ Sbjct: 236 AQDEVFSLAFSPNR 249 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 25/86 (29%), Positives = 41/86 (47%), Gaps = 4/86 (4%) Query: 183 IKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSA 242 ++ + GH + + + D LS S D LRLW++ T F GH+ +V+S Sbjct: 58 VRSFKGHSHIVQDCTL-TADGAYALSASWDKTLRLWDVATGETYQRF---VGHKSDVMSV 113 Query: 243 DYDLLGEKIMSCGMDHSLKLWRINSK 268 D D I+S D ++K+W I + Sbjct: 114 DIDKKASMIISGSRDKTIKVWTIKGQ 139 Score = 35.8 bits (81), Expect = 0.034, Method: Compositional matrix adjust. Identities = 28/86 (32%), Positives = 38/86 (44%), Gaps = 14/86 (16%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFG----GVEGH----RDEV 239 GH + L PNLLLS S+D L W + D FG +GH +D Sbjct: 15 GHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDD--QKFGVPVRSFKGHSHIVQDCT 72 Query: 240 LSADYDLLGEKIMSCGMDHSLKLWRI 265 L+AD G +S D +L+LW + Sbjct: 73 LTAD----GAYALSASWDKTLRLWDV 94 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 25/103 (24%), Positives = 49/103 (47%), Gaps = 15/103 (14%) Query: 172 IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGG 231 +R+ + T + + +VGH + + + + ++++S S+D +++W I+ L + Sbjct: 89 LRLWDVATGETYQRFVGHKSDVMSVDIDKK-ASMIISGSRDKTIKVWTIKGQCLATLL-- 145 Query: 232 VEGHRDEVLS--------ADYDLLGEKIMSCGMDHSLKLWRIN 266 GH D V AD D + I+S G D +K W +N Sbjct: 146 --GHNDWVSQVRVVPNEKADDDSV--TIISAGNDKMVKAWNLN 184 >6QX9-4B nrPDB Length = 522 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 23/83 (27%), Positives = 39/83 (46%), Gaps = 3/83 (3%) Query: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 240 +C+ H N + +KF P N LL+ + D+ ++W T + + GH +V+ Sbjct: 440 RCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIW---THPGWSPLKTLAGHEGKVM 496 Query: 241 SADYDLLGEKIMSCGMDHSLKLW 263 D G+ I +C D + KLW Sbjct: 497 GLDISSDGQLIATCSYDRTFKLW 519 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 23/92 (25%), Positives = 45/92 (48%), Gaps = 4/92 (4%) Query: 183 IKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSA 242 I H GH + ++ FH +D +L + D R+W+++T + +EGH E+ Sbjct: 358 ILHQEGHSMGVYDIAFH-QDGSLAGTGGLDAFGRVWDLRTGRCIMF---LEGHLKEIYGI 413 Query: 243 DYDLLGEKIMSCGMDHSLKLWRINSKRMMNAI 274 ++ G I + D++ K+W + +R + I Sbjct: 414 NFSPNGYHIATGSGDNTCKVWDLRQRRCVYTI 445 >4XYI-A nrPDB Length = 430 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 50/103 (48%), Gaps = 6/103 (5%) Query: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 240 QC+K H +N + F+P + LL + S DH + LW+++ L +EGH DEV Sbjct: 275 QCVK---AHEQPVNGVAFNPFNDYLLATASADHTVALWDLR--RLNQRLHTLEGHEDEVY 329 Query: 241 SADYDLLGEKIM-SCGMDHSLKLWRINSKRMMNAIKESYDYNP 282 + + E I+ + D + +W ++ +++S D P Sbjct: 330 NVQWSPHDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAP 372 Score = 35.0 bits (79), Expect = 0.066, Method: Compositional matrix adjust. Identities = 23/95 (24%), Positives = 46/95 (48%), Gaps = 4/95 (4%) Query: 178 ITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRD 237 I + + Y H +N+L+FH + LL SVS D L++ + + + + V+ H Sbjct: 223 IDVAPVSVYHRHTAVVNDLQFHLQHEALLTSVSDDCTLQIHDTRLPSSSSASQCVKAHEQ 282 Query: 238 EVLSADYDLLGEKIMSCG-MDHSLKLW---RINSK 268 V ++ + +++ DH++ LW R+N + Sbjct: 283 PVNGVAFNPFNDYLLATASADHTVALWDLRRLNQR 317 >5GAN-H nrPDB Length = 465 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 43/180 (23%), Positives = 85/180 (47%), Gaps = 21/180 (11%) Query: 88 LKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVT-LYECHSQGEIRLLQSYVDADADEN 146 L+E H++ +F + F + D + + G + ++ L++ S ++ L A + Sbjct: 302 LQEGHDKGVFSLSF-----QCDGSLVCSGGMDSLSMLWDIRSGSKVMTL-----AGHSKP 351 Query: 147 FYTCAWTYDSNTSHPLLAVAGSRGIIRI--INPITMQCIKHYVGHGNAINELKFHPRDPN 204 YT AW+ + +A G GII + I + + H N + +++F D Sbjct: 352 IYTVAWSPNGYQ----VATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGG 407 Query: 205 L-LLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLW 263 L+S D+ + +++ +DT + + G + GH D+++S D ++S G D S+KLW Sbjct: 408 KKLVSCGYDNLINVYS--SDTWLKM-GSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLW 464 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 4/88 (4%) Query: 180 MQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEV 239 ++ + VGH I+++K+HP + S S D RLW+ T + + EGH V Sbjct: 255 LRLLGDLVGHERRISDVKYHP-SGKFIGSASHDMTWRLWDASTHQELLL---QEGHDKGV 310 Query: 240 LSADYDLLGEKIMSCGMDHSLKLWRINS 267 S + G + S GMD LW I S Sbjct: 311 FSLSFQCDGSLVCSGGMDSLSMLWDIRS 338 Score = 32.0 bits (71), Expect = 0.58, Method: Compositional matrix adjust. Identities = 27/127 (21%), Positives = 60/127 (47%), Gaps = 7/127 (5%) Query: 157 NTSHPLLAVAGSRGIIRIINPITMQCIKHYV-GHGNAINELKFHPRDPNLLLSVSKDHAL 215 +T ++A G ++++N T+Q + + H I + +HP N ++S ++D + Sbjct: 184 STDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLI 243 Query: 216 RLWNIQ---TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMN 272 + N Q + + + G + GH + Y G+ I S D + +LW ++ + + Sbjct: 244 K--NFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQEL- 300 Query: 273 AIKESYD 279 ++E +D Sbjct: 301 LLQEGHD 307 >3MKQ-A nrPDB Length = 814 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 38/159 (23%), Positives = 69/159 (43%), Gaps = 15/159 (9%) Query: 109 DPLVFATVGSNRVTLYECHSQGEIRLLQ-SYVDADADENFYTCAWTYDSNTSHPLLAVAG 167 +P V T+ S RV ++ +Q E+R +Q + A + W + V Sbjct: 25 EPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIARKNW----------IIVGS 74 Query: 168 SRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVA 227 IR+ N T + + + H + I + HP P +LS S D ++LWN + + A Sbjct: 75 DDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKP-YVLSGSDDLTVKLWNWENNW--A 131 Query: 228 IFGGVEGHRDEVLSADYDLLGEKIMSCG-MDHSLKLWRI 265 + EGH V+ ++ + G +D ++K+W + Sbjct: 132 LEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSL 170 Score = 36.2 bits (82), Expect = 0.028, Method: Compositional matrix adjust. Identities = 22/84 (26%), Positives = 43/84 (51%), Gaps = 4/84 (4%) Query: 188 GHGNAINELKFHPR-DPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDL 246 G +N + ++P D +++ S D +++W+ QT + VA +EGH V A + Sbjct: 182 GQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVAT---LEGHMSNVSFAVFHP 238 Query: 247 LGEKIMSCGMDHSLKLWRINSKRM 270 I+S D +LK+W ++ ++ Sbjct: 239 TLPIIISGSEDGTLKIWNSSTYKV 262 Score = 35.4 bits (80), Expect = 0.051, Method: Compositional matrix adjust. Identities = 19/62 (30%), Positives = 32/62 (51%), Gaps = 1/62 (1%) Query: 161 PLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI 220 P + A I+I + T C+ GH + ++ FHP P +++S S+D L++WN Sbjct: 199 PYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLP-IIISGSEDGTLKIWNS 257 Query: 221 QT 222 T Sbjct: 258 ST 259 Score = 31.2 bits (69), Expect = 0.89, Method: Compositional matrix adjust. Identities = 21/87 (24%), Positives = 42/87 (48%), Gaps = 4/87 (4%) Query: 184 KHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSAD 243 + + GH + + + F+P+DP+ S D +++W++ T F G V D Sbjct: 134 QTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQST--PNFTLTTGQERGVNYVD 191 Query: 244 YDLLGEK--IMSCGMDHSLKLWRINSK 268 Y L +K +++ D ++K+W +K Sbjct: 192 YYPLPDKPYMITASDDLTIKIWDYQTK 218 >6G51-g nrPDB Length = 317 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 33/147 (22%), Positives = 63/147 (42%), Gaps = 25/147 (17%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTL------VAIFGGVEGHRDEVLS 241 GH + ++ P+ P+++LS S+D + +W + D A+ G D V+S Sbjct: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72 Query: 242 ADYDLLGEKIMSCGMDHSLKLWRI----NSKRMMNAIKESYDYNPNKTNRPFIS------ 291 +D G+ +S D +L+LW + ++R + K+ + NR +S Sbjct: 73 SD----GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT 128 Query: 292 ----QKIHFPDFSTRD-IHRNYVDCVR 313 + ++ +D H +V CVR Sbjct: 129 IKLWNTLGVCKYTVQDESHSEWVSCVR 155 Score = 35.8 bits (81), Expect = 0.041, Method: Compositional matrix adjust. Identities = 29/152 (19%), Positives = 65/152 (42%), Gaps = 8/152 (5%) Query: 138 YVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELK 197 Y D + + + N+S+P++ G ++++ N + +++GH +N + Sbjct: 140 YTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVT 199 Query: 198 FHPRDPNLLLSVSKDHALRLWNI-QTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGM 256 P D +L S KD LW++ + L + GG ++++A + Sbjct: 200 VSP-DGSLCASGGKDGQAMLWDLNEGKHLYTLDGG------DIINALCFSPNRYWLCAAT 252 Query: 257 DHSLKLWRINSKRMMNAIKESYDYNPNKTNRP 288 S+K+W + K +++ +K+ +K P Sbjct: 253 GPSIKIWDLEGKIIVDELKQEVISTSSKAEPP 284 >6Q8F-A nrPDB Length = 514 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 28/115 (24%), Positives = 52/115 (45%), Gaps = 5/115 (4%) Query: 162 LLAVAGSRGIIRIINPITMQCIKHYV-GHGNAINELKFHPRDPNLLLSVSKDHALRLWNI 220 +LA G I++ + QC++ + H + L F +D + +LS S D +R+ + Sbjct: 279 MLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSF-SKDSSQILSASFDQTIRIHGL 337 Query: 221 QTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK 275 ++ + F GH V A + G I+S D ++K+W + + N K Sbjct: 338 KSGKTLKEF---RGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFK 389 Score = 37.4 bits (85), Expect = 0.013, Method: Compositional matrix adjust. Identities = 39/146 (26%), Positives = 66/146 (45%), Gaps = 22/146 (15%) Query: 296 FPDFSTRDI---HRNYVDCVRWL--GDLILSKSCENAIVCWK--PGKMEDDIDKIKPSES 348 FP +R I +++V+C R+ G +++ S + I W GK+ D+ ++ Sbjct: 202 FPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKY--QAQD 259 Query: 349 NVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHK 408 N ++ D C M FS D +MLA G Q GK+ VW ++ +C Sbjct: 260 NFMMMD--DAVLC----MCFSRD--TEMLATGAQDGKIKVWKIQ-----SGQCLRRFERA 306 Query: 409 CGAAIRQTSFSRDSSILIAVCDDASI 434 + SFS+DSS +++ D +I Sbjct: 307 HSKGVTCLSFSKDSSQILSASFDQTI 332 >4U1E-I nrPDB Length = 347 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 25/91 (27%), Positives = 51/91 (56%), Gaps = 7/91 (7%) Query: 180 MQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLW-NIQTDTLVAIFGGVEGHRDE 238 M+ IK GH + ++K++ ++ +LL S SKD + +W ++ + L G ++GH Sbjct: 1 MKAIK-LTGHERPLTQVKYN-KEGDLLFSCSKDSSASVWYSLNGERL----GTLDGHTGT 54 Query: 239 VLSADYDLLGEKIMSCGMDHSLKLWRINSKR 269 + S D D + ++ D+S+KLW +++ + Sbjct: 55 IWSIDVDCFTKYCVTGSADYSIKLWDVSNGQ 85 >5YZG-W nrPDB Length = 579 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 21/76 (27%), Positives = 34/76 (44%), Gaps = 2/76 (2%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247 GH ++ ++ P +LLLS S D ++LW + + GH V ++ Sbjct: 286 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGER--RCLRTFIGHSKAVRDICFNTA 343 Query: 248 GEKIMSCGMDHSLKLW 263 G + +S D LKLW Sbjct: 344 GTQFLSAAYDRYLKLW 359 Score = 33.1 bits (74), Expect = 0.26, Method: Compositional matrix adjust. Identities = 13/49 (26%), Positives = 28/49 (57%), Gaps = 1/49 (2%) Query: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIF 229 +C++ ++GH A+ ++ F+ LS + D L+LW+ +T ++ F Sbjct: 323 RCLRTFIGHSKAVRDICFNTAGTQ-FLSAAYDRYLKLWDTETGQCISRF 370 Score = 27.7 bits (60), Expect = 9.2, Method: Compositional matrix adjust. Identities = 10/26 (38%), Positives = 16/26 (61%) Query: 244 YDLLGEKIMSCGMDHSLKLWRINSKR 269 + L G ++SC MD +KLW + +R Sbjct: 297 FPLSGHLLLSCSMDCKIKLWEVYGER 322 >5I2T-A nrPDB Length = 742 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 23/88 (26%), Positives = 43/88 (48%), Gaps = 3/88 (3%) Query: 183 IKHYV--GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 240 ++H V GH I L + +D +L+ SKD + ++W++ ++ GHRD V+ Sbjct: 162 VRHRVHAGHFQDITSLTW-SQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVM 220 Query: 241 SADYDLLGEKIMSCGMDHSLKLWRINSK 268 A + EKI + D ++ +W + Sbjct: 221 GAFFSHDQEKIYTVSKDGAVFVWEFTKR 248 Score = 38.1 bits (87), Expect = 0.007, Method: Compositional matrix adjust. Identities = 19/76 (25%), Positives = 41/76 (53%), Gaps = 4/76 (5%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247 GH ++ N L + P D + +++ S+D +++W+I + +A F E H V + + Sbjct: 368 GHFDSTNSLAYSP-DGSRVVTASEDGKIKVWDITSGFCLATF---EEHTSSVTAVQFAKR 423 Query: 248 GEKIMSCGMDHSLKLW 263 G+ + S +D +++ W Sbjct: 424 GQVMFSSSLDGTVRAW 439 Score = 35.0 bits (79), Expect = 0.057, Method: Compositional matrix adjust. Identities = 31/133 (23%), Positives = 53/133 (39%), Gaps = 6/133 (4%) Query: 147 FYTCAWTYDSNTSHP---LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDP 203 FY T HP LLAV + G R+ + I+ N +N + + Sbjct: 281 FYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGE 340 Query: 204 NLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLW 263 L SK L ++ Q+++ + +GH D S Y G ++++ D +K+W Sbjct: 341 WLAFGSSKLGQLLVYEWQSESYIL---KQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVW 397 Query: 264 RINSKRMMNAIKE 276 I S + +E Sbjct: 398 DITSGFCLATFEE 410 >6QDV-o nrPDB Length = 513 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 21/76 (27%), Positives = 34/76 (44%), Gaps = 2/76 (2%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247 GH ++ ++ P +LLLS S D ++LW + + GH V ++ Sbjct: 220 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGER--RCLRTFIGHSKAVRDICFNTA 277 Query: 248 GEKIMSCGMDHSLKLW 263 G + +S D LKLW Sbjct: 278 GTQFLSAAYDRYLKLW 293 Score = 33.1 bits (74), Expect = 0.26, Method: Compositional matrix adjust. Identities = 13/49 (26%), Positives = 28/49 (57%), Gaps = 1/49 (2%) Query: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIF 229 +C++ ++GH A+ ++ F+ LS + D L+LW+ +T ++ F Sbjct: 257 RCLRTFIGHSKAVRDICFNTAGTQ-FLSAAYDRYLKLWDTETGQCISRF 304 Score = 27.7 bits (60), Expect = 9.9, Method: Compositional matrix adjust. Identities = 10/26 (38%), Positives = 16/26 (61%) Query: 244 YDLLGEKIMSCGMDHSLKLWRINSKR 269 + L G ++SC MD +KLW + +R Sbjct: 231 FPLSGHLLLSCSMDCKIKLWEVYGER 256 >5WLC-LO nrPDB Length = 923 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 23/88 (26%), Positives = 43/88 (48%), Gaps = 3/88 (3%) Query: 183 IKHYV--GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 240 ++H V GH I L + +D +L+ SKD + ++W++ ++ GHRD V+ Sbjct: 137 VRHRVHAGHFQDITSLTW-SQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVM 195 Query: 241 SADYDLLGEKIMSCGMDHSLKLWRINSK 268 A + EKI + D ++ +W + Sbjct: 196 GAFFSHDQEKIYTVSKDGAVFVWEFTKR 223 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 19/76 (25%), Positives = 41/76 (53%), Gaps = 4/76 (5%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247 GH ++ N L + P D + +++ S+D +++W+I + +A F E H V + + Sbjct: 343 GHFDSTNSLAYSP-DGSRVVTASEDGKIKVWDITSGFCLATF---EEHTSSVTAVQFAKR 398 Query: 248 GEKIMSCGMDHSLKLW 263 G+ + S +D +++ W Sbjct: 399 GQVMFSSSLDGTVRAW 414 Score = 34.7 bits (78), Expect = 0.076, Method: Compositional matrix adjust. Identities = 31/133 (23%), Positives = 53/133 (39%), Gaps = 6/133 (4%) Query: 147 FYTCAWTYDSNTSHP---LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDP 203 FY T HP LLAV + G R+ + I+ N +N + + Sbjct: 256 FYANQAKVKCVTFHPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGE 315 Query: 204 NLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLW 263 L SK L ++ Q+++ + +GH D S Y G ++++ D +K+W Sbjct: 316 WLAFGSSKLGQLLVYEWQSESYIL---KQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVW 372 Query: 264 RINSKRMMNAIKE 276 I S + +E Sbjct: 373 DITSGFCLATFEE 385 >6EOJ-D nrPDB Length = 470 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 20/73 (27%), Positives = 40/73 (54%), Gaps = 3/73 (4%) Query: 152 WTYDSNTSHP---LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLS 208 W S HP L+A A ++++ +P + CI + + + + +F P NLL++ Sbjct: 220 WDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMA 279 Query: 209 VSKDHALRLWNIQ 221 +SKD + R+++I+ Sbjct: 280 ISKDKSCRVFDIR 292 Score = 36.6 bits (83), Expect = 0.022, Method: Compositional matrix adjust. Identities = 41/170 (24%), Positives = 74/170 (43%), Gaps = 14/170 (8%) Query: 105 SKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLA 164 + EG LV AT S +L+ S L+Q++ D T +++DS+ + Sbjct: 102 TPEGRRLVVATY-SGEFSLWNASSFTFETLMQAH-----DSAVTTMKYSHDSD----WMI 151 Query: 165 VAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDT 224 + G+I+I P + H +I ++ F D + ++ S D+ L++WN Sbjct: 152 SGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSND-SKFVTCSDDNILKIWNFSNGK 210 Query: 225 LVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAI 274 + + GH +V S D+ I S D+ +KLW S +++I Sbjct: 211 QERV---LSGHHWDVKSCDWHPEMGLIASASKDNLVKLWDPRSGNCISSI 257 >4V7E-Bg nrPDB Length = 380 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 29/110 (26%), Positives = 47/110 (42%), Gaps = 5/110 (4%) Query: 180 MQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGV--EGHRD 237 M + GH + ++ P L++ S D LW++ T ++IFG GH Sbjct: 147 MPVSRVLTGHKGYASSCQYVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTA 206 Query: 238 EVLSADYDLLGEKIMSCG-MDHSLKLW--RINSKRMMNAIKESYDYNPNK 284 +VLS + L + G D +++LW RI S+ + D N K Sbjct: 207 DVLSLSINSLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVK 256 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 37/189 (19%), Positives = 73/189 (38%), Gaps = 38/189 (20%) Query: 175 INPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEG 234 NP + C + GH + L + P + N ++S S+D L +WN T ++ Sbjct: 51 FNPTDLVCCRTLQGHSGKVYSLDWTP-EKNWIVSASQDGRLIVWNALTSQKTH---AIKL 106 Query: 235 HRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSK----------RMMNAIK---ESYDYN 281 H V+ + G+ + G+D + ++ ++S+ R++ K S Y Sbjct: 107 HCPWVMECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYV 166 Query: 282 PNKTNRPF--------------ISQKI-----HFPDFSTRDIHRNYVDCVRWLGDLILSK 322 P++ R Q+I FP T D+ ++ + ++ +S Sbjct: 167 PDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLN--ANMFISG 224 Query: 323 SCENAIVCW 331 SC+ + W Sbjct: 225 SCDTTVRLW 233 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 1/52 (1%) Query: 178 ITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIF 229 IT + ++ Y GH IN +KF P D + S D RL++++T + ++ Sbjct: 237 ITSRAVRTYHGHEGDINSVKFFP-DGQRFGTGSDDGTCRLFDMRTGHQLQVY 287 >5K0Y-T nrPDB Length = 329 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 26/102 (25%), Positives = 52/102 (50%), Gaps = 12/102 (11%) Query: 175 INPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLW-NIQTDTLVAIFGGVE 233 + PI +Q GH +I ++K++ R+ +LL +V+KD + +W ++ + L G Sbjct: 1 MRPILLQ------GHERSITQIKYN-REGDLLFTVAKDPIVNVWYSVNGERL----GTYM 49 Query: 234 GHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK 275 GH V D D + +++ D+S +LW + + + +K Sbjct: 50 GHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLK 91 >6GMH-W nrPDB Length = 305 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 4/82 (4%) Query: 163 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQT 222 LA GII I + T + + GH I L F P D LL++ S D ++++++Q Sbjct: 163 LASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSP-DSQLLVTASDDGYIKIYDVQH 221 Query: 223 DTLVAIFGGVEGHRDEVLSADY 244 L G + GH VL+ + Sbjct: 222 ANLA---GTLSGHASWVLNVAF 240 >5OQL-d nrPDB Length = 446 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 28/102 (27%), Positives = 50/102 (49%), Gaps = 6/102 (5%) Query: 164 AVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQT- 222 +VA R II M IK + A N + F+P + L S+DH + +++ + Sbjct: 215 SVATDRSIILFDLRTNMPVIKTVLHF--ACNRIVFNPMEAMNLAVASEDHNIYIFDARNF 272 Query: 223 DTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 D + I +GH V+ ++ GE+++S D +++LWR Sbjct: 273 DKALNI---QKGHVAAVMDVEFSPTGEELVSGSYDRTIRLWR 311 >3CFV-B nrPDB Length = 414 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 22/94 (23%), Positives = 46/94 (48%), Gaps = 1/94 (1%) Query: 186 YVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYD 245 + GH + ++ +H +L SV+ D L +W+ +++T V+ H EV ++ Sbjct: 225 FTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFN 284 Query: 246 LLGEKIMSCG-MDHSLKLWRINSKRMMNAIKESY 278 E I++ G D ++ LW + + ++ ES+ Sbjct: 285 PYSEFILATGSADKTVALWDLRNLKLKLHTFESH 318 Score = 28.9 bits (63), Expect = 4.6, Method: Compositional matrix adjust. Identities = 10/33 (30%), Positives = 23/33 (69%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNI 220 GH I++ ++P +P ++ SVS+D+ +++W + Sbjct: 374 GHTAKISDFSWNPNEPWVICSVSEDNIMQIWQM 406 >2AQ5-A nrPDB Length = 402 Score = 37.4 bits (85), Expect = 0.013, Method: Compositional matrix adjust. Identities = 33/118 (27%), Positives = 52/118 (44%), Gaps = 11/118 (9%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247 GH + + +HP N+LLS D+ + +W++ T V G + H D + S D+ Sbjct: 129 GHTKRVGIVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGP-DVHPDTIYSVDWSRD 187 Query: 248 GEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRP----FISQ-KIHFPDFS 300 G I + D K R+ R + E P++ RP F+S+ KI FS Sbjct: 188 GALICTSCRD---KRVRVIEPRKGTVVAEK--DRPHEGTRPVHAVFVSEGKILTTGFS 240 Score = 28.5 bits (62), Expect = 5.8, Method: Compositional matrix adjust. Identities = 20/85 (23%), Positives = 40/85 (47%), Gaps = 5/85 (5%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFG----GVEGHRDEV-LSA 242 GH + ++ + P + N++ S S+D + +W I LV +EGH V + A Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVGIVA 138 Query: 243 DYDLLGEKIMSCGMDHSLKLWRINS 267 + ++S G D+ + +W + + Sbjct: 139 WHPTAQNVLLSAGCDNVILVWDVGT 163 >5WYJ-BC nrPDB Length = 817 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 32/123 (26%), Positives = 57/123 (46%), Gaps = 8/123 (6%) Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPN---LLL 207 ++ D++++ LLAV G+ G I +++ + GHG I+ LKF+ + + LL Sbjct: 105 SYILDADSTSTLLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYGQLNSKIWLLA 164 Query: 208 SVSKDHALRLWNIQ----TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLW 263 S + +++W++ TL V G D + D D ++S G D + LW Sbjct: 165 SGDTNGMVKVWDLVKRKCLHTLQEHTSAVRG-LDIIEVPDNDEPSLNLLSGGRDDIINLW 223 Query: 264 RIN 266 N Sbjct: 224 DFN 226 Score = 33.5 bits (75), Expect = 0.18, Method: Compositional matrix adjust. Identities = 17/70 (24%), Positives = 37/70 (52%), Gaps = 3/70 (4%) Query: 205 LLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 LL + S D +++W++ T ++ +EGH + V + ++++SCG D +K+W Sbjct: 547 LLATSSGDKTVKIWSLDT---FSVMKTLEGHTNAVQRCSFINKQKQLISCGADGLIKIWD 603 Query: 265 INSKRMMNAI 274 +S + + Sbjct: 604 CSSGECLKTL 613 Score = 28.9 bits (63), Expect = 4.5, Method: Compositional matrix adjust. Identities = 20/88 (22%), Positives = 40/88 (45%), Gaps = 4/88 (4%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247 H IN L P D ++ + S D ++WN++ L A + +V YD L Sbjct: 489 AHEKDINALSVSPND-SIFATASYDKTCKIWNLENGELEATLANHKRGLWDVSFCQYDKL 547 Query: 248 GEKIMSCGMDHSLKLWRINSKRMMNAIK 275 + + D ++K+W +++ +M ++ Sbjct: 548 ---LATSSGDKTVKIWSLDTFSVMKTLE 572 >5FVM-C nrPDB Length = 303 Score = 37.0 bits (84), Expect = 0.016, Method: Compositional matrix adjust. Identities = 51/238 (21%), Positives = 90/238 (37%), Gaps = 31/238 (13%) Query: 54 DTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLF-----GVQFNWHSKEG 108 D +N PN KG S + + + S ED ++ VQ N+ K Sbjct: 59 DIRSNNPNPVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNY--KHN 116 Query: 109 DPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGS 168 P+ + N+ L C G IR+ D EN T T + NT L+VA Sbjct: 117 APVNEVAIHPNQGELISCDQDGNIRIW------DLGENQCTNQLTPEDNTPLQSLSVASD 170 Query: 169 RGIIRIIN---------------PITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDH 213 ++ N T++ + + H I + D L + S DH Sbjct: 171 GSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLL-SADVKNLATCSADH 229 Query: 214 ALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMM 271 R+WNI+ + + ++GH+ V + +++ DH ++LW +++ ++ Sbjct: 230 TARVWNIEDN--YQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDLSTSEIV 285 Score = 33.1 bits (74), Expect = 0.24, Method: Compositional matrix adjust. Identities = 47/253 (18%), Positives = 96/253 (37%), Gaps = 36/253 (14%) Query: 163 LAVAGSRGI----IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLW 218 LA AG + IR NP + + GH + + F ++ ++S S+D +++W Sbjct: 47 LAAAGHLHVRLYDIRSNNP---NPVSSFEGHKGNVTSIAFQ-QENRWMVSSSEDGTIKVW 102 Query: 219 NIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESY 278 ++++ ++ + H V +++SC D ++++W + + N + Sbjct: 103 DVRSPSVQRNYK----HNAPVNEVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPE- 157 Query: 279 DYNP----------------NKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSK 322 D P N ++ + H D ST + + +++ ++LS Sbjct: 158 DNTPLQSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSA 217 Query: 323 SCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQ 382 +N C D ++ E N + D Q +W FS D + A + Sbjct: 218 DVKNLATC-----SADHTARVWNIEDNYQLETTLDGHQRWVWDCAFSADSAYLVTACSDH 272 Query: 383 VGKLYVWDLEVED 395 +L WDL + Sbjct: 273 YVRL--WDLSTSE 283 Score = 32.7 bits (73), Expect = 0.30, Method: Compositional matrix adjust. Identities = 57/245 (23%), Positives = 95/245 (38%), Gaps = 53/245 (21%) Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221 +LA AG IR +T C + + +N L+ D L + H +RL++I+ Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEI-TSDKKYLAAAGHLH-VRLYDIR 61 Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN 281 ++ + EGH+ V S + ++S D ++K+W + S +++ +Y Sbjct: 62 SNNPNPV-SSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSP----SVQRNY--- 113 Query: 282 PNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCEN--AIVCWKPGKMEDD 339 K N P IH P+ G+LI SC+ I W G+ + Sbjct: 114 --KHNAPVNEVAIH-PN----------------QGELI---SCDQDGNIRIWDLGENQ-C 150 Query: 340 IDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKA 399 +++ P E N + S+ ML GN G YVW + PH Sbjct: 151 TNQLTP-EDNTPL-------------QSLSVASDGSMLVAGNNKGNCYVWRM----PHHT 192 Query: 400 KCTTL 404 +TL Sbjct: 193 DASTL 197 Score = 29.3 bits (64), Expect = 3.2, Method: Compositional matrix adjust. Identities = 11/30 (36%), Positives = 18/30 (60%) Query: 202 DPNLLLSVSKDHALRLWNIQTDTLVAIFGG 231 D L++ DH +RLW++ T +V +GG Sbjct: 261 DSAYLVTACSDHYVRLWDLSTSEIVRQYGG 290 >6N9G-C nrPDB Length = 353 Score = 37.0 bits (84), Expect = 0.017, Method: Compositional matrix adjust. Identities = 20/89 (22%), Positives = 47/89 (52%), Gaps = 10/89 (11%) Query: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 240 QC++ + H + +N ++++P + S S D RL++++ D VAI+ ++ ++ Sbjct: 230 QCVQAFETHESDVNSVRYYP-SGDAFASGSDDATCRLYDLRADREVAIYS-----KESII 283 Query: 241 ----SADYDLLGEKIMSCGMDHSLKLWRI 265 S D+ L G + + D+++ +W + Sbjct: 284 FGASSVDFSLSGRLLFAGYNDYTINVWDV 312 >5WLC-LJ nrPDB Length = 513 Score = 37.0 bits (84), Expect = 0.018, Method: Compositional matrix adjust. Identities = 28/114 (24%), Positives = 48/114 (42%), Gaps = 14/114 (12%) Query: 110 PLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSR 169 P FA S RV ++ ++ I+ + D Y+ ++ D LL + Sbjct: 52 PHDFAVTSSTRVQIFSSRTRQVIKTFSRFKDV-----VYSASFRSDGK----LLCAGDAT 102 Query: 170 GIIRII---NPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI 220 G++ + NP T+ + H + KFH +D +L + S D RLW+I Sbjct: 103 GLVSVYDSYNPRTILLSINASTHPTHVT--KFHTQDNKILATASDDRVTRLWDI 154 >5CXC-A nrPDB Length = 510 Score = 37.0 bits (84), Expect = 0.019, Method: Compositional matrix adjust. Identities = 17/59 (28%), Positives = 29/59 (49%) Query: 206 LLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 +LS S D LR+WN + G G + A L +++ S GMD ++++W+ Sbjct: 161 VLSASYDGLLRIWNASGSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRTVRVWK 219 Score = 32.0 bits (71), Expect = 0.49, Method: Compositional matrix adjust. Identities = 19/70 (27%), Positives = 33/70 (47%), Gaps = 3/70 (4%) Query: 156 SNTSHPLLAVAGSRGIIRIINPITMQCIKHYV---GHGNAINELKFHPRDPNLLLSVSKD 212 + T+ PLLA S I +++P + GH N + L P + L+S S D Sbjct: 366 AGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHD 425 Query: 213 HALRLWNIQT 222 R+W++++ Sbjct: 426 GTCRVWDLRS 435 >4BH6-A nrPDB Length = 308 Score = 36.6 bits (83), Expect = 0.021, Method: Compositional matrix adjust. Identities = 33/124 (26%), Positives = 61/124 (49%), Gaps = 8/124 (6%) Query: 145 ENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPN 204 EN YT + ++ SH LAV + G++ I + + +CI+ GH + + L + + + Sbjct: 62 ENEYT-SLSWIGAGSH--LAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSW---NNH 115 Query: 205 LLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 +L S S+DH R+ + F +E H EV +++ K+ S G D+ + ++ Sbjct: 116 VLTSGSRDH--RILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYE 173 Query: 265 INSK 268 SK Sbjct: 174 GTSK 177 >5NZU-C nrPDB Length = 905 Score = 36.6 bits (83), Expect = 0.023, Method: Compositional matrix adjust. Identities = 23/96 (23%), Positives = 47/96 (48%), Gaps = 5/96 (5%) Query: 182 CIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLS 241 C + + GH + + ++ +P+D N S S D +++W + + + +EGH V Sbjct: 134 CSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFT---LEGHEKGVNC 190 Query: 242 ADYDLLGEK--IMSCGMDHSLKLWRINSKRMMNAIK 275 DY G+K ++S D +K+W +K + ++ Sbjct: 191 IDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLE 226 Score = 35.0 bits (79), Expect = 0.068, Method: Compositional matrix adjust. Identities = 22/97 (22%), Positives = 47/97 (48%), Gaps = 4/97 (4%) Query: 172 IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTD-TLVAIFG 230 IR+ N T++ + + H + I + HP P +L+ S D ++LW+ + +F Sbjct: 81 IRVFNYNTLERVHMFEAHSDYIRCIAVHPTQP-FILTSSDDMLIKLWDWDKKWSCSQVFE 139 Query: 231 GVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 267 G + +++ D + S +D ++K+W++ S Sbjct: 140 GHTHYVMQIVINPKD--NNQFASASLDRTIKVWQLGS 174 Score = 33.9 bits (76), Expect = 0.16, Method: Compositional matrix adjust. Identities = 28/126 (22%), Positives = 52/126 (41%), Gaps = 27/126 (21%) Query: 154 YDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDH 213 Y S P L +++I + C++ GH ++ FHP P ++++ S+D Sbjct: 193 YYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELP-IIITGSEDG 251 Query: 214 ALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNA 273 +R+W+ S+ Y L E ++ GM+ ++W + S R N Sbjct: 252 TVRIWH---------------------SSTYRL--ESTLNYGME---RVWCVASLRGSNN 285 Query: 274 IKESYD 279 + YD Sbjct: 286 VALGYD 291 >5A9Q-2 nrPDB Length = 326 Score = 36.6 bits (83), Expect = 0.025, Method: Compositional matrix adjust. Identities = 15/34 (44%), Positives = 22/34 (64%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221 GH + IN L F P++ + SVS DH R+WN++ Sbjct: 122 GHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLE 155 >5Y1U-A nrPDB Length = 456 Score = 36.2 bits (82), Expect = 0.027, Method: Compositional matrix adjust. Identities = 19/86 (22%), Positives = 42/86 (48%), Gaps = 1/86 (1%) Query: 186 YVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYD 245 + GH + ++ +H +L SV+ D L +W+ +++ V+ H EV ++ Sbjct: 254 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 313 Query: 246 LLGEKIMSCG-MDHSLKLWRINSKRM 270 E I++ G D ++ LW + + ++ Sbjct: 314 PYSEFILATGSADKTVALWDLRNLKL 339 Score = 28.9 bits (63), Expect = 5.2, Method: Compositional matrix adjust. Identities = 10/33 (30%), Positives = 23/33 (69%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNI 220 GH I++ ++P +P ++ SVS+D+ +++W + Sbjct: 403 GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 435 Score = 28.5 bits (62), Expect = 6.2, Method: Compositional matrix adjust. Identities = 50/212 (23%), Positives = 80/212 (37%), Gaps = 47/212 (22%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNI----QTDTLVAIFGGVEGHRDEVLSAD 243 GH L ++P LLS S DH + LW+I + +V GH V Sbjct: 206 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 265 Query: 244 YDLLGEKIM-SCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTR 302 + LL E + S D L +W D N T++P S Sbjct: 266 WHLLHESLFGSVADDQKLMIW---------------DTRSNNTSKPSHS----------V 300 Query: 303 DIHRNYVDCVRW--LGDLILSK-SCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYS 359 D H V+C+ + + IL+ S + + W D+ +K L F+ Sbjct: 301 DAHTAEVNCLSFNPYSEFILATGSADKTVALW-------DLRNLK------LKLHSFESH 347 Query: 360 QCDIWYMRFSMDFWQKMLALGNQVGKLYVWDL 391 + +I+ +++S + +LA +L VWDL Sbjct: 348 KDEIFQVQWSPHN-ETILASSGTDRRLNVWDL 378 >5A31-R nrPDB Length = 386 Score = 36.2 bits (82), Expect = 0.028, Method: Compositional matrix adjust. Identities = 33/124 (26%), Positives = 61/124 (49%), Gaps = 8/124 (6%) Query: 145 ENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPN 204 EN YT + ++ SH LAV + G++ I + + +CI+ GH + + L + + + Sbjct: 131 ENEYT-SLSWIGAGSH--LAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSW---NNH 184 Query: 205 LLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 +L S S+DH R+ + F +E H EV +++ K+ S G D+ + ++ Sbjct: 185 VLTSGSRDH--RILHRDVRMPDPFFETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYE 242 Query: 265 INSK 268 SK Sbjct: 243 GTSK 246 >4PSX-B nrPDB Length = 401 Score = 35.8 bits (81), Expect = 0.037, Method: Compositional matrix adjust. Identities = 32/133 (24%), Positives = 62/133 (46%), Gaps = 20/133 (15%) Query: 147 FYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM-QCIKHYVGHGNAINELKFHPRDPNL 205 F T A+++ S+ LLA AG + + + M + + H GH +A+N L+F + Sbjct: 254 FNTLAFSHHSSN---LLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTHVDGV 310 Query: 206 LLSVSKDHALRLWNIQT-----------DTLVAIFGGVEGHRDEVLSADYDLLGE---KI 251 ++S D+ L +W+++ D + + GHR V D+DL + + Sbjct: 311 VVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSV--NDFDLNPQIPWLV 368 Query: 252 MSCGMDHSLKLWR 264 S ++ L++W+ Sbjct: 369 ASAEEENILQVWK 381 Score = 29.6 bits (65), Expect = 2.9, Method: Compositional matrix adjust. Identities = 17/80 (21%), Positives = 43/80 (53%), Gaps = 5/80 (6%) Query: 189 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYD-LL 247 H I ++ P+DPN++ +++ L++ +++ L + ++ H+D + + L+ Sbjct: 117 HEEEITRARYMPQDPNIVATINGQGTTFLYS-RSEGLQST---LKFHKDNGYALSFSTLV 172 Query: 248 GEKIMSCGMDHSLKLWRINS 267 +++S DH++ LW + S Sbjct: 173 KGRLLSGSDDHTVALWEVGS 192 >5WJC-A nrPDB Length = 430 Score = 35.8 bits (81), Expect = 0.040, Method: Compositional matrix adjust. Identities = 24/96 (25%), Positives = 43/96 (44%), Gaps = 3/96 (3%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247 H AIN + +P + LL + S D + LW+++ +EGH DEV ++ Sbjct: 279 AHSKAINAVAINPFNDYLLATASADKTVALWDLRNP--YQRLHTLEGHEDEVYGLEWSPH 336 Query: 248 GEKIM-SCGMDHSLKLWRINSKRMMNAIKESYDYNP 282 E I+ S D + +W + +++ D +P Sbjct: 337 DEPILASSSTDRRVCIWDLEKIGEEQTPEDAEDGSP 372 Score = 33.1 bits (74), Expect = 0.22, Method: Compositional matrix adjust. Identities = 20/94 (21%), Positives = 46/94 (48%), Gaps = 6/94 (6%) Query: 173 RIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGV 232 ++I+PI Y H + +N+++FHP+ LL SVS D L++ + + + + Sbjct: 223 KVISPIA-----KYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVI 277 Query: 233 EGHRDEVLSADYDLLGEKIMSCG-MDHSLKLWRI 265 + H + + + + +++ D ++ LW + Sbjct: 278 QAHSKAINAVAINPFNDYLLATASADKTVALWDL 311 >6EMK-B nrPDB Length = 303 Score = 35.4 bits (80), Expect = 0.045, Method: Compositional matrix adjust. Identities = 37/181 (20%), Positives = 72/181 (39%), Gaps = 24/181 (13%) Query: 106 KEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTS------ 159 K P+ + N+ L C G IR+ D EN T T + +TS Sbjct: 114 KHNAPVNEVVIHPNQGELISCDRDGNIRIW------DLGENQCTHQLTPEDDTSLQSLSM 167 Query: 160 ---HPLLAVAGSRGIIRI------INPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS 210 +LA A ++G + + ++ + + H I + D L + S Sbjct: 168 ASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILL-SSDVKHLATCS 226 Query: 211 KDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRM 270 DH R+W+I D + ++GH+ V + +++ DH ++LW ++++ + Sbjct: 227 ADHTARVWSIDDD--FKLETTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTREI 284 Query: 271 M 271 + Sbjct: 285 V 285 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 28/120 (23%), Positives = 53/120 (44%), Gaps = 7/120 (5%) Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221 +L AG IR +T C + + +N L+ + LL+ + +RL++I+ Sbjct: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEI--TNDKKLLATAGHQNVRLYDIR 61 Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN 281 T + EGHR V S + +++ D ++K+W + S +I +Y +N Sbjct: 62 TTNPNPV-ASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSP----SIPRNYKHN 116 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 12/30 (40%), Positives = 19/30 (63%) Query: 202 DPNLLLSVSKDHALRLWNIQTDTLVAIFGG 231 D L++ S DH +RLW++ T +V +GG Sbjct: 261 DSAYLVTASSDHYVRLWDLSTREIVRQYGG 290 >3C9C-A nrPDB Length = 432 Score = 35.4 bits (80), Expect = 0.050, Method: Compositional matrix adjust. Identities = 19/86 (22%), Positives = 41/86 (47%), Gaps = 1/86 (1%) Query: 186 YVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYD 245 + GH + ++ +H +L SV+ D L +W+ + + V+ H EV ++ Sbjct: 229 FTGHTAVVEDVAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFN 288 Query: 246 LLGEKIMSCG-MDHSLKLWRINSKRM 270 E I++ G D ++ LW + + ++ Sbjct: 289 PYSEFILATGSADKTVALWDLRNLKL 314 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 49/212 (23%), Positives = 81/212 (38%), Gaps = 47/212 (22%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNI----QTDTLVAIFGGVEGHRDEVLSAD 243 GH L ++P LLS S DH + LW+I + ++ GH V Sbjct: 181 GHQKEGYGLSWNPNLNGYLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVEDVA 240 Query: 244 YDLLGEKIM-SCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTR 302 + LL E + S D L +W D N T++P T Sbjct: 241 WHLLHESLFGSVADDQKLMIW---------------DTRNNNTSKP----------SHTV 275 Query: 303 DIHRNYVDCVRW--LGDLILSK-SCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYS 359 D H V+C+ + + IL+ S + + W D+ +K L F+ Sbjct: 276 DAHTAEVNCLSFNPYSEFILATGSADKTVALW-------DLRNLKLK------LHSFESH 322 Query: 360 QCDIWYMRFSMDFWQKMLALGNQVGKLYVWDL 391 + +I+ +++S + +LA +L+VWDL Sbjct: 323 KDEIFQVQWSPHN-ETILASSGTDRRLHVWDL 353 Score = 28.9 bits (63), Expect = 4.4, Method: Compositional matrix adjust. Identities = 10/33 (30%), Positives = 23/33 (69%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNI 220 GH I++ ++P +P ++ SVS+D+ +++W + Sbjct: 378 GHTAKISDFSWNPNEPWIICSVSEDNIMQVWQM 410 >3ACP-A nrPDB Length = 417 Score = 35.0 bits (79), Expect = 0.059, Method: Compositional matrix adjust. Identities = 23/81 (28%), Positives = 39/81 (48%), Gaps = 12/81 (14%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTD----TLVAIFGGVEGHRDEVLSAD 243 H + I +LKF P L+S S+D L++W+++ TL+ GHR V Sbjct: 134 AHVSEITKLKFFPSGE-ALISSSQDMQLKIWSVKDGSNPRTLI-------GHRATVTDIA 185 Query: 244 YDLLGEKIMSCGMDHSLKLWR 264 G ++S +D +++LW Sbjct: 186 IIDRGRNVLSASLDGTIRLWE 206 >5MWJ-A nrPDB Length = 337 Score = 35.0 bits (79), Expect = 0.074, Method: Compositional matrix adjust. Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 4/81 (4%) Query: 192 AINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKI 251 A L P D + S D + +W++ TLV F +GH D D G K+ Sbjct: 143 ACYALAISP-DSKVCFSCCSDGNIAVWDLHNQTLVRQF---QGHTDGASCIDISNDGTKL 198 Query: 252 MSCGMDHSLKLWRINSKRMMN 272 + G+D++++ W + R + Sbjct: 199 WTGGLDNTVRSWDLREGRQLQ 219 Score = 31.6 bits (70), Expect = 0.76, Method: Compositional matrix adjust. Identities = 19/63 (30%), Positives = 28/63 (44%), Gaps = 6/63 (9%) Query: 377 LALGNQVGKLYVWDLEVEDPH-KAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIW 435 L +G + L +WDL P KA+ T+ A + S DS + + C D +I Sbjct: 112 LIVGGEASTLSIWDLAAPTPRIKAELTS-----SAPACYALAISPDSKVCFSCCSDGNIA 166 Query: 436 RWD 438 WD Sbjct: 167 VWD 169 >5WYK-BB nrPDB Length = 943 Score = 34.7 bits (78), Expect = 0.081, Method: Compositional matrix adjust. Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 4/83 (4%) Query: 182 CIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLS 241 C K H ++I +KF P+ N S SKD ++ W+ + + + H+ EV + Sbjct: 607 CHKSLFAHQDSIMNVKFLPQSHNFF-SCSKDAVVKYWDGEKFECIQ---KLYAHQSEVWA 662 Query: 242 ADYDLLGEKIMSCGMDHSLKLWR 264 G ++S DHS+++W Sbjct: 663 LAVATDGGFVVSSSHDHSIRIWE 685 Score = 34.7 bits (78), Expect = 0.092, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 57/109 (52%), Gaps = 7/109 (6%) Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221 LLAV + G+I++ + ++ + ++ GH AI L+F L+S SKD + +W++ Sbjct: 93 LLAVGYADGVIKVWDLMSKTVLLNFNGHKAAITLLQFDGTGTR-LISGSKDSNIIVWDLV 151 Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEK-IMSCGMDHSLKLWRINSKR 269 + V ++ + H+D + + GE ++S D +KLW + + + Sbjct: 152 GE--VGLY-KLRSHKDSI--TGFWCQGEDWLISTSKDGMIKLWDLKTHQ 195 Score = 29.6 bits (65), Expect = 2.8, Method: Compositional matrix adjust. Identities = 14/65 (21%), Positives = 34/65 (52%), Gaps = 3/65 (4%) Query: 201 RDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSL 260 +D +LL D +++W++ + T++ F GH+ + +D G +++S D ++ Sbjct: 89 KDTDLLAVGYADGVIKVWDLMSKTVLLNFN---GHKAAITLLQFDGTGTRLISGSKDSNI 145 Query: 261 KLWRI 265 +W + Sbjct: 146 IVWDL 150 >4A11-B nrPDB Length = 408 Score = 34.3 bits (77), Expect = 0.099, Method: Compositional matrix adjust. Identities = 49/231 (21%), Positives = 93/231 (40%), Gaps = 39/231 (16%) Query: 157 NTSHPLLAVAGSRG-IIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHAL 215 +T H L+AV G+RG +++ + + C GH I + + PR +L + S D + Sbjct: 153 STKHCLVAV-GTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDYILATASADSRV 211 Query: 216 RLWNIQ--TDTLV-----------AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKL 262 +LW+++ + L+ A+ H +V + G +++ G D+ ++L Sbjct: 212 KLWDVRRASGCLITLDQHNGKKSQAVESANTAHNGKVNGLCFTSDGLHLLTVGTDNRMRL 271 Query: 263 WR--------INSKRMMNAIKESYDY------NPNKTNRPFISQKIHFPDFSTRDI---- 304 W +N ++ N K+ + + P+ S + +S I Sbjct: 272 WNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLK 331 Query: 305 -HRNYVDCVRWLGDL--ILSKSCENAIVCWKPGKME---DDIDKIKPSESN 349 H VDC + + + S S + I+ W P E DD + S+ N Sbjct: 332 GHYKTVDCCVFQSNFQELYSGSRDCNILAWVPSLYEPVPDDDETTTKSQLN 382 >3W15-A nrPDB Length = 368 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 39/140 (27%), Positives = 58/140 (41%), Gaps = 27/140 (19%) Query: 151 AWTYDSNTSHP-LLAVAGSRGIIRI-------INPITMQ---CIKHYV-GHGNAINELKF 198 A T D N P ++A G IRI NP + CI HG AI ++ + Sbjct: 225 ALTCDFNKYRPYVVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTW 284 Query: 199 HPRDPNLLLSVSKDHALRLW----------NIQTDTLVAIFGGV---EGHRDEVLSADYD 245 P N+L+S S D R+W +T++ A G + H + V AD+ Sbjct: 285 SPHHSNILMSASYDMTCRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWS 344 Query: 246 LLGEK--IMSCGMDHSLKLW 263 L G+ + S D +L +W Sbjct: 345 LWGKPGYVASTAWDGNLFVW 364 Score = 32.7 bits (73), Expect = 0.34, Method: Compositional matrix adjust. Identities = 44/231 (19%), Positives = 97/231 (41%), Gaps = 28/231 (12%) Query: 171 IIRIINPITMQCIKHYVGHG-----NAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTL 225 I ++++P+ +K G N + + +F P D NL+LS S + L++I+ + Sbjct: 152 ITKMVDPLNAIILKKKSFTGISKNRNCVYQAQFSPHDQNLVLSCSGNSYASLFDIRLPSG 211 Query: 226 VAIFGGVEGHRDEVLSADYDLLGEKIMSC-GMDHSLKLWRINSKRMMNAIKESYDYNPNK 284 + E L+ D++ +++ G+D+++++W I RM+N NP + Sbjct: 212 KNQNNFLVHSGLEALTCDFNKYRPYVVATGGVDNAIRIWDI---RMLNK-------NPGQ 261 Query: 285 TNRPFISQKIHFPDFSTRDIHRNYVDCVRWL---GDLILSKSCENAIVCWKPGKMEDDID 341 + +I + H + V W ++++S S + W+ + + Sbjct: 262 LHNSSCINEI-------PNAHGLAIRKVTWSPHHSNILMSASYDMTCRIWRDLSNDGAKE 314 Query: 342 KIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQV--GKLYVWD 390 K + ++ T F+++Q + W K + + G L+VW+ Sbjct: 315 TYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGNLFVWN 365 >5L9T-R nrPDB Length = 493 Score = 33.9 bits (76), Expect = 0.14, Method: Compositional matrix adjust. Identities = 34/154 (22%), Positives = 55/154 (35%), Gaps = 42/154 (27%) Query: 157 NTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLS--VSKDHA 214 +T H LLA G+ + + N ++ ++ Y H A+ + + P LL S + D Sbjct: 322 STDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRC 381 Query: 215 LRLWNIQT----------------------DTLVAIFG------------------GVEG 234 +R WN T + LV+ G + G Sbjct: 382 IRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTG 441 Query: 235 HRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSK 268 H VL GE I++ D +L+ W + SK Sbjct: 442 HSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSK 475 Score = 31.2 bits (69), Expect = 0.99, Method: Compositional matrix adjust. Identities = 34/138 (24%), Positives = 60/138 (43%), Gaps = 12/138 (8%) Query: 126 CHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKH 185 C SQ RL V+ D+ + W+ N L+AV +G ++I + + + Sbjct: 215 CTSQ-VTRLCDLSVEGDS---VTSVGWSERGN----LVAVGTHKGFVQIWDAAAGKKLSM 266 Query: 186 YVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYD 245 GH + L ++ L S S+D + +I+T L + ++GHR EV + Sbjct: 267 LEGHTARVGALAWNAEQ---LSSGSRDRMILQRDIRTPPLQS-ERRLQGHRQEVCGLKWS 322 Query: 246 LLGEKIMSCGMDHSLKLW 263 + + S G D+ L +W Sbjct: 323 TDHQLLASGGNDNKLLVW 340 >5WYJ-BE nrPDB Length = 939 Score = 33.9 bits (76), Expect = 0.15, Method: Compositional matrix adjust. Identities = 19/64 (29%), Positives = 32/64 (50%), Gaps = 1/64 (1%) Query: 159 SHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLW 218 S L A+A I +I+ +T + ++ GH N I F P + ++S S D +R W Sbjct: 554 SSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSP-EGRWIVSASLDSTIRTW 612 Query: 219 NIQT 222 ++ T Sbjct: 613 DLPT 616 >6CVZ-A nrPDB Length = 351 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 16/58 (27%), Positives = 33/58 (56%) Query: 172 IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIF 229 +++++ M+ ++ HG I L F LLLS S D+ ++L +++T+T+V + Sbjct: 56 VKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTY 113 >4FHN-A nrPDB Length = 394 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 25/105 (23%), Positives = 49/105 (46%), Gaps = 16/105 (15%) Query: 205 LLLSVSKDHALRLWNIQTDTLVA--IFGGVEGHRD--------EVLSADYDLLGEKIMSC 254 L V +D+ +RL + +T++ + GG GH + +V SAD L + I S Sbjct: 104 FLACVCQDNTVRLIITKNETIITQHVLGGKSGHHNFVNDIDIADVYSADNRLAEQVIASV 163 Query: 255 GMDHSLKLWRIN------SKRMMNAIKESYDYNPNKTNRPFISQK 293 G D +L +WR+ + +++ S + P+ N+ + ++ Sbjct: 164 GDDCTLIIWRLTDEGPILAGYPLSSPGISVQFRPSNPNQLIVGER 208 >5FA5-B nrPDB Length = 367 Score = 33.5 bits (75), Expect = 0.20, Method: Compositional matrix adjust. Identities = 22/92 (23%), Positives = 42/92 (45%), Gaps = 5/92 (5%) Query: 170 GIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIF 229 G + +++ + C+ H + L F P L S+S+D +L + + +L +F Sbjct: 260 GTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLD---SSLSELF 316 Query: 230 GGVEGHRDEVLSADYDLLGEKIM-SCGMDHSL 260 + HRD V A + L ++ + G DH + Sbjct: 317 RS-QAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 >2HES-X nrPDB Length = 330 Score = 32.7 bits (73), Expect = 0.33, Method: Compositional matrix adjust. Identities = 29/126 (23%), Positives = 55/126 (43%), Gaps = 17/126 (13%) Query: 152 WTYDSNTSHPLLAVAGSRGIIRII----NPITMQCIKHYVGHGNAINELKFHPRDPNLLL 207 W++D S +LA + I+++ + T+ + H AI + + P +LL Sbjct: 18 WSFD--FSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPH-TSLLA 74 Query: 208 SVSKDHALRLWNIQTDT-------LVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSL 260 + S D + +W + L+AI +EGH +EV + G + +C D S+ Sbjct: 75 AGSFDSTVSIWAKEESADRTFEMDLLAI---IEGHENEVKGVAWSNDGYYLATCSRDKSV 131 Query: 261 KLWRIN 266 +W + Sbjct: 132 WIWETD 137 >3JB9-L nrPDB Length = 340 Score = 32.3 bits (72), Expect = 0.44, Method: Compositional matrix adjust. Identities = 20/104 (19%), Positives = 46/104 (44%), Gaps = 4/104 (3%) Query: 176 NPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGH 235 + ++ Q I+ + GH +N L LL SVS D +++W+ ++ + Sbjct: 121 DAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTI----EE 176 Query: 236 RDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 279 + + + G ++ G+D ++K+W + + + +K D Sbjct: 177 KYPLTAVAIAQQGTQVFIGGIDGAIKIWDLRNNHCSHVLKGHKD 220 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 14/32 (43%), Positives = 17/32 (53%) Query: 234 GHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI 265 GH EVL A +D G S GMD + LW + Sbjct: 48 GHTAEVLVARFDPSGSYFASGGMDRQILLWNV 79 Score = 28.1 bits (61), Expect = 8.9, Method: Compositional matrix adjust. Identities = 27/122 (22%), Positives = 56/122 (45%), Gaps = 22/122 (18%) Query: 105 SKEGDPLVFATVGSNRVTLYE----CHSQGEIRLLQSYVDADADENFYTCAWTYDS---- 156 SK+G L+ ++ N V +++ +Q ++++ + + + N AW+ +S Sbjct: 228 SKDGSSLLSNSM-DNTVRIFDVKPFASAQRQLQIFEGAIHGQ-EHNLLGVAWSRNSRFVG 285 Query: 157 -NTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHAL 215 +S + V + G +R + P GH ++N + FHP +++LS S D + Sbjct: 286 AGSSDKNVYVWSATGDLRYVLP----------GHEGSVNHVDFHPH-QDIILSCSSDRTI 334 Query: 216 RL 217 L Sbjct: 335 FL 336 >4AEZ-A nrPDB Length = 401 Score = 32.0 bits (71), Expect = 0.49, Method: Compositional matrix adjust. Identities = 47/199 (23%), Positives = 87/199 (43%), Gaps = 33/199 (16%) Query: 141 ADADENFYTCA--WTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKF 198 A+ DE+ Y + W++D + L+V G++ I + + ++ GH + L + Sbjct: 129 AETDESTYVASVKWSHDGS----FLSVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSW 184 Query: 199 HPRDPNLLLSVSKD-----HALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMS 253 + ++L S S+ H +R+ N Q TL +GH EV + G ++ S Sbjct: 185 ---NRHVLSSGSRSGAIHHHDVRIANHQIGTL-------QGHSSEVCGLAWRSDGLQLAS 234 Query: 254 CGMDHSLKLWRINS------KRMMNAIKESYDYNPNKTNR-----PFISQKIHFPDFSTR 302 G D+ +++W S K NA ++ + P ++N + ++IHF + +T Sbjct: 235 GGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAAT- 293 Query: 303 DIHRNYVDCVRWLGDLILS 321 N VD + LI S Sbjct: 294 GARVNTVDAGSQVTSLIWS 312 >2PM9-A nrPDB Length = 416 Score = 32.0 bits (71), Expect = 0.60, Method: Compositional matrix adjust. Identities = 18/66 (27%), Positives = 32/66 (48%), Gaps = 2/66 (3%) Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221 LL +G + + NP + + + + GN + KF P P+L S D+ + + +Q Sbjct: 277 LLLSSGRDNTVLLWNPESAEQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKIEVQTLQ 336 Query: 222 --TDTL 225 T+TL Sbjct: 337 NLTNTL 342 >5OQL-J nrPDB Length = 912 Score = 31.2 bits (69), Expect = 0.86, Method: Compositional matrix adjust. Identities = 14/35 (40%), Positives = 22/35 (62%) Query: 232 VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRIN 266 ++GH D V+S D D G I S D++ +LWR++ Sbjct: 429 LKGHEDIVMSLDVDWSGHWIASGSKDNTARLWRVD 463 >5MC6-j nrPDB Length = 397 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 26/133 (19%), Positives = 56/133 (42%), Gaps = 22/133 (16%) Query: 162 LLAVAGSRGIIRIINPITMQCIKHY------VGHGNAINELKFHPRDPNLLLSVSKDH-- 213 L+A + G ++I T++ + ++ + + N+I +KF P+ LL+++ D Sbjct: 199 LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGS--LLAIAHDSNS 256 Query: 214 --ALRLWNIQTDTLVAIFG----------GVEGHRDEVLSADYDLLGEKIMSCGMDHSLK 261 + L+ + + G H V+S ++ GE + S G D L+ Sbjct: 257 FGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCSAGWDGKLR 316 Query: 262 LWRINSKRMMNAI 274 W + +K + + Sbjct: 317 FWDVKTKERITTL 329 Score = 27.7 bits (60), Expect = 9.4, Method: Compositional matrix adjust. Identities = 20/63 (31%), Positives = 28/63 (44%), Gaps = 7/63 (11%) Query: 345 PSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTL 404 P+ S+ LG F +S W M S + + L GKL WD++ K + TTL Sbjct: 277 PTHSSQASLGEFAHSS---WVMSLSFNDSGETLCSAGWDGKLRFWDVKT----KERITTL 329 Query: 405 THH 407 H Sbjct: 330 NMH 332 >4LG8-A nrPDB Length = 354 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 20/86 (23%), Positives = 41/86 (47%), Gaps = 4/86 (4%) Query: 190 GNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGE 249 G ++ +FHP D + + + D +++W+++ T VA F GH + S + G Sbjct: 200 GCSLTCAQFHP-DGLIFGTGTMDSQIKIWDLKERTNVANF---PGHSGPITSIAFSENGY 255 Query: 250 KIMSCGMDHSLKLWRINSKRMMNAIK 275 + + D S+KLW + + ++ Sbjct: 256 YLATAADDSSVKLWDLRKLKNFKTLQ 281 >5A9Q-0 nrPDB Length = 380 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 19/64 (29%), Positives = 32/64 (50%), Gaps = 3/64 (4%) Query: 162 LLAVAGSRGIIRI--INPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWN 219 ++A G G++ I + TM + H + E+ FHP +P L + S+D +L W+ Sbjct: 232 VVATGGQDGMLSIWDVRQGTMP-VSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWD 290 Query: 220 IQTD 223 TD Sbjct: 291 ASTD 294 >6BX3-A nrPDB Length = 314 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 20/86 (23%), Positives = 38/86 (44%), Gaps = 5/86 (5%) Query: 189 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLG 248 H +EL + P D + + S D ++ + ++ L G H V+S ++ G Sbjct: 53 HARPFSELCWSP-DGQCIATASDDFSVEIIHLSYGLLHTFIG----HTAPVISLTFNRKG 107 Query: 249 EKIMSCGMDHSLKLWRINSKRMMNAI 274 + + MD S+K+W + +M I Sbjct: 108 NLLFTSSMDESIKIWDTLNGSLMKTI 133 >5Z56-q nrPDB Length = 504 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 20/74 (27%), Positives = 37/74 (50%), Gaps = 4/74 (5%) Query: 190 GNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGE 249 G ++ +FHP D + + + D +++W+++ T VA F GH + S + G Sbjct: 350 GCSLTCAQFHP-DGLIFGTGTMDSQIKIWDLKERTNVANF---PGHSGPITSIAFSENGY 405 Query: 250 KIMSCGMDHSLKLW 263 + + D S+KLW Sbjct: 406 YLATAADDSSVKLW 419 >4G56-B nrPDB Length = 357 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 7/83 (8%) Query: 206 LLSVSKDHALRLWNI--QTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLW 263 +L S A+ LW I + LV F E H D V + G + +S G D S+K+W Sbjct: 108 ILVASDSGAVELWEILEKESLLVNKFAKYE-HDDIVKTLSVFSDGTQAVSGGKDFSVKVW 166 Query: 264 RINSKRMMNAIKESYDYNPNKTN 286 ++ K A+ +SY+ + ++ N Sbjct: 167 DLSQK----AVLKSYNAHSSEVN 185 >6CHG-A nrPDB Length = 312 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 27/100 (27%), Positives = 43/100 (43%), Gaps = 11/100 (11%) Query: 183 IKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVE---GHRDEV 239 +K H IN L + P D + S S+D + + +I I+G + GH V Sbjct: 47 MKLTTTHKECINCLCWSP-DSKCIASGSEDFTVEITHI-------IYGRIRRLMGHTAPV 98 Query: 240 LSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 279 +S Y+ G + S MD S+K W + S + + D Sbjct: 99 ISICYNNKGNILCSSSMDESIKEWHVLSGTALKTMSAHSD 138 >4OWR-A nrPDB Length = 339 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 21/83 (25%), Positives = 39/83 (46%), Gaps = 3/83 (3%) Query: 191 NAINELKFHPRD--PNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLG 248 ++I L F P N L++ S + +R W +Q D+ I + H VL + G Sbjct: 11 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQ-DSGQTIPKAQQMHTGPVLDVCWSDDG 69 Query: 249 EKIMSCGMDHSLKLWRINSKRMM 271 K+ + D + K+W ++S + + Sbjct: 70 SKVFTASCDKTAKMWDLSSNQAI 92 >2I2W-A nrPDB Length = 212 Score = 30.0 bits (66), Expect = 2.2, Method: Compositional matrix adjust. Identities = 30/95 (31%), Positives = 39/95 (41%), Gaps = 12/95 (12%) Query: 235 HRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFI--SQ 292 R VL AD G K++SCG S + M A + + Y N+ P I S Sbjct: 51 QRAAVLLADSFKAGGKVLSCGNGGS------HCDAMHFAEELTGRYRENRPGYPAIAISD 104 Query: 293 KIHFP----DFSTRDIHRNYVDCVRWLGDLILSKS 323 H DF DI YV+ V GD++L S Sbjct: 105 VSHISCVGNDFGFNDIFSRYVEAVGREGDVLLGIS 139 >5G04-R nrPDB Length = 499 Score = 29.6 bits (65), Expect = 2.9, Method: Compositional matrix adjust. Identities = 26/94 (27%), Positives = 38/94 (40%), Gaps = 5/94 (5%) Query: 172 IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS-KDHALRLWNIQTDTLVAIFG 230 IRI N + C+ H + L + P L+ + L +W T VA Sbjct: 382 IRIWNVCSGACLSAVDAHSQVCSIL-WSPHYKELISGHGFAQNQLVIWKYPTMAKVA--- 437 Query: 231 GVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 ++GH VLS G + S D +L+LWR Sbjct: 438 ELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 >4GGA-A nrPDB Length = 420 Score = 29.3 bits (64), Expect = 3.3, Method: Compositional matrix adjust. Identities = 26/94 (27%), Positives = 38/94 (40%), Gaps = 5/94 (5%) Query: 172 IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS-KDHALRLWNIQTDTLVAIFG 230 IRI N + C+ H + L + P L+ + L +W T VA Sbjct: 303 IRIWNVCSGACLSAVDAHSQVCSIL-WSPHYKELISGHGFAQNQLVIWKYPTMAKVA--- 358 Query: 231 GVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 ++GH VLS G + S D +L+LWR Sbjct: 359 ELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 392 >1PI6-A nrPDB Length = 615 Score = 29.3 bits (64), Expect = 3.4, Method: Compositional matrix adjust. Identities = 17/44 (38%), Positives = 22/44 (50%), Gaps = 1/44 (2%) Query: 396 PHKAKCTTLTHHKCGAAIRQTSFSRDSS-ILIAVCDDASIWRWD 438 P K + THHK G+ +R FS DS +I V D I +D Sbjct: 192 PFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFD 235 >5LCW-Q nrPDB Length = 374 Score = 29.3 bits (64), Expect = 3.4, Method: Compositional matrix adjust. Identities = 26/94 (27%), Positives = 38/94 (40%), Gaps = 5/94 (5%) Query: 172 IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS-KDHALRLWNIQTDTLVAIFG 230 IRI N + C+ H + L + P L+ + L +W T VA Sbjct: 257 IRIWNVCSGACLSAVDAHSQVCSIL-WSPHYKELISGHGFAQNQLVIWKYPTMAKVA--- 312 Query: 231 GVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 ++GH VLS G + S D +L+LWR Sbjct: 313 ELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 346 >1X7P-A nrPDB Length = 287 Score = 29.3 bits (64), Expect = 3.5, Method: Compositional matrix adjust. Identities = 15/61 (24%), Positives = 32/61 (52%), Gaps = 5/61 (8%) Query: 327 AIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQ-KMLALGNQVGK 385 A+ PG++ D ++ + + + + ++G ++ CD+ F DF Q +L +GN+ Sbjct: 182 AVRVPSPGEVMDWVEARRAAGTPIVLVGTDEHGDCDV----FDFDFTQPTLLLIGNETAG 237 Query: 386 L 386 L Sbjct: 238 L 238 >5A9Q-7 nrPDB Length = 360 Score = 28.9 bits (63), Expect = 4.6, Method: Compositional matrix adjust. Identities = 9/29 (31%), Positives = 17/29 (58%) Query: 235 HRDEVLSADYDLLGEKIMSCGMDHSLKLW 263 H+D + +D G ++ +C D S+K+W Sbjct: 11 HKDLIHDVSFDFHGRRMATCSSDQSVKVW 39 >4N14-A nrPDB Length = 314 Score = 28.9 bits (63), Expect = 4.7, Method: Compositional matrix adjust. Identities = 26/94 (27%), Positives = 38/94 (40%), Gaps = 5/94 (5%) Query: 172 IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS-KDHALRLWNIQTDTLVAIFG 230 IRI N + C+ H + L + P L+ + L +W T VA Sbjct: 219 IRIWNVCSGACLSAVDAHSQVCSIL-WSPHYKELISGHGFAQNQLVIWKYPTMAKVA--- 274 Query: 231 GVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 ++GH VLS G + S D +L+LWR Sbjct: 275 ELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 308 >3ODT-A nrPDB Length = 313 Score = 28.5 bits (62), Expect = 6.1, Method: Compositional matrix adjust. Identities = 13/56 (23%), Positives = 31/56 (55%), Gaps = 2/56 (3%) Query: 170 GIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTL 225 G+I++++ T ++ Y GH + + +K P ++S +D +R+W+ + +L Sbjct: 205 GLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD--IVSCGEDRTVRIWSKENGSL 258 >6N8P-A nrPDB Length = 979 Score = 28.1 bits (61), Expect = 7.5, Method: Compositional matrix adjust. Identities = 22/91 (24%), Positives = 42/91 (46%), Gaps = 5/91 (5%) Query: 193 INELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIM 252 + L+ HPRDPN +L + +W++Q ++ F + + E + D G ++ Sbjct: 180 VEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHF--LSSQQLENIWWQRD--GRLLV 235 Query: 253 SCGMDHSLKLWRINSK-RMMNAIKESYDYNP 282 SC D S W ++S+ + ++ Y P Sbjct: 236 SCHSDGSYCQWPVSSEAQQPEPLRSLVPYGP 266 >5TF2-A nrPDB Length = 407 Score = 28.1 bits (61), Expect = 7.5, Method: Compositional matrix adjust. Identities = 19/70 (27%), Positives = 33/70 (47%), Gaps = 4/70 (5%) Query: 157 NTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALR 216 N + LLA G+ G +R+ +++ + + H I +L P L++V +D Sbjct: 181 NHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGK--LVTVGRDLKAS 238 Query: 217 LWNIQTDTLV 226 +W Q D LV Sbjct: 239 VW--QKDQLV 246 >5IV7-F nrPDB Length = 288 Score = 28.1 bits (61), Expect = 7.6, Method: Compositional matrix adjust. Identities = 16/58 (27%), Positives = 28/58 (48%), Gaps = 2/58 (3%) Query: 168 SRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTL 225 S G I + NP+T+Q I G + N + P L +S D++ +WN +++ Sbjct: 112 SNGSISVTNPLTIQAIDSI--KGVSGNLVVTSPYSKVTLRCISSDNSTSVWNYSIESM 167 >5WLC-LU nrPDB Length = 489 Score = 28.1 bits (61), Expect = 7.8, Method: Compositional matrix adjust. Identities = 24/87 (27%), Positives = 38/87 (43%), Gaps = 8/87 (9%) Query: 188 GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTD----TLVAIFGGVEG---HRDEVL 240 GH + + + + N L + S D ++ WN+ T + A +G V G + Sbjct: 65 GHRDGVYAIAKNYGSLNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTQPRFH 124 Query: 241 SADYDLLGEKIM-SCGMDHSLKLWRIN 266 DL + M SC D ++KLW IN Sbjct: 125 DKKPDLKSQNFMLSCSDDKTVKLWSIN 151 >6BX3-B nrPDB Length = 412 Score = 28.1 bits (61), Expect = 8.6, Method: Compositional matrix adjust. Identities = 14/48 (29%), Positives = 25/48 (52%), Gaps = 3/48 (6%) Query: 210 SKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMD 257 S H L +W + TLV + +EG +E++ ++D I+S G + Sbjct: 288 SSAHELYIWETTSGTLVRV---LEGAEEELIDINWDFYSMSIVSNGFE 332 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3JZG-A nrPDB 560 e-160 5BJS-A nrPDB 245 3e-65 6QX9-5O nrPDB 225 2e-59 6J6H-n nrPDB 217 1e-56 4BTS-AR nrPDB 190 1e-48 5M25-A nrPDB 190 1e-48 1VYH-C nrPDB 184 6e-47 6MZM-G nrPDB 183 1e-46 6F3T-A nrPDB 183 1e-46 2H9P-A nrPDB 182 3e-46 4V8M-A7 nrPDB 179 2e-45 5MZH-A nrPDB 179 2e-45 5OPT-p nrPDB 179 3e-45 5NNZ-B nrPDB 175 3e-44 3JB9-g nrPDB 169 2e-42 5FL8-q nrPDB 168 4e-42 3MKQ-A nrPDB 165 3e-41 6G51-g nrPDB 163 1e-40 4V6W-Ag nrPDB 163 2e-40 2YNP-A nrPDB 163 2e-40 6HQA-B nrPDB 154 6e-38 3DM0-A nrPDB 152 2e-37 5GAN-H nrPDB 147 9e-36 6QX9-4B nrPDB 141 4e-34 5K1B-B nrPDB 134 7e-32 6ID0-T nrPDB 132 2e-31 6HHQ-h nrPDB 129 2e-30 5Y88-O nrPDB 125 5e-29 4XYI-A nrPDB 123 1e-28 3JAP-g nrPDB 123 2e-28 3FM0-A nrPDB 122 2e-28 5OQL-X nrPDB 105 4e-23 5XYI-g nrPDB 97 2e-20 Sequences not found previously or not previously below threshold: 6QDV-o nrPDB 148 4e-36 5YZG-W nrPDB 148 5e-36 5NZU-C nrPDB 147 1e-35 3JB9-L nrPDB 134 7e-32 5WJC-A nrPDB 122 4e-28 6Q8F-A nrPDB 120 1e-27 5Z56-q nrPDB 120 1e-27 4LG8-A nrPDB 118 6e-27 5WLC-LO nrPDB 113 1e-25 4V7E-Bg nrPDB 113 1e-25 5I2T-A nrPDB 113 2e-25 6N9G-C nrPDB 112 2e-25 6EOJ-D nrPDB 110 2e-24 5WYJ-BC nrPDB 109 3e-24 4J0W-A nrPDB 108 6e-24 5OQL-J nrPDB 106 2e-23 5WYK-BB nrPDB 104 8e-23 4GGA-A nrPDB 104 9e-23 5G04-R nrPDB 103 1e-22 5LCW-Q nrPDB 103 1e-22 5L9T-R nrPDB 102 3e-22 4N14-A nrPDB 102 4e-22 2AQ5-A nrPDB 101 7e-22 5OQL-L nrPDB 100 3e-21 5Y1U-A nrPDB 99 3e-21 5UZ7-B nrPDB 99 4e-21 3C9C-A nrPDB 98 8e-21 4YCZ-A nrPDB 98 8e-21 6EMK-B nrPDB 98 8e-21 2HES-X nrPDB 98 8e-21 4A11-B nrPDB 97 1e-20 5FVM-C nrPDB 97 1e-20 3JRO-A nrPDB 97 2e-20 3CFV-B nrPDB 94 1e-19 6GMH-W nrPDB 94 1e-19 6ELZ-p nrPDB 94 1e-19 4L9O-A nrPDB 92 5e-19 6BX3-A nrPDB 91 9e-19 4XFV-A nrPDB 91 1e-18 3JRP-A nrPDB 90 1e-18 5MWJ-A nrPDB 89 4e-18 1NR0-A nrPDB 88 5e-18 4BZK-B nrPDB 88 5e-18 3BG0-A nrPDB 87 1e-17 5A9Q-2 nrPDB 87 2e-17 6CHG-A nrPDB 86 3e-17 5A31-R nrPDB 86 3e-17 4BH6-A nrPDB 85 9e-17 3ODT-A nrPDB 83 3e-16 5OQL-d nrPDB 83 3e-16 5WLC-LU nrPDB 82 4e-16 4U1E-I nrPDB 81 1e-15 4AEZ-A nrPDB 80 1e-15 3ACP-A nrPDB 80 2e-15 4OWR-A nrPDB 80 3e-15 5OV3-A nrPDB 78 8e-15 4PSX-B nrPDB 77 2e-14 5K0Y-T nrPDB 77 2e-14 5WBU-D nrPDB 77 2e-14 5WLC-LJ nrPDB 76 3e-14 3W15-A nrPDB 74 1e-13 5WYJ-BE nrPDB 72 6e-13 4E5Z-B nrPDB 72 8e-13 5N4A-A nrPDB 70 1e-12 1PI6-A nrPDB 70 2e-12 5A9Q-7 nrPDB 69 4e-12 5CXB-B nrPDB 68 1e-11 4G56-B nrPDB 67 2e-11 5CXC-A nrPDB 67 2e-11 2PM9-A nrPDB 67 2e-11 5WLC-SG nrPDB 66 3e-11 4J0X-A nrPDB 66 3e-11 5FA5-B nrPDB 65 5e-11 5A9Q-0 nrPDB 65 6e-11 6BX3-B nrPDB 64 1e-10 3F3P-A nrPDB 63 2e-10 6CB1-s nrPDB 63 2e-10 5MC6-j nrPDB 63 2e-10 6CHG-D nrPDB 63 3e-10 6F1U-h nrPDB 63 3e-10 6C0F-s nrPDB 63 3e-10 6EM1-m nrPDB 62 4e-10 6E29-D nrPDB 62 4e-10 5WLC-LW nrPDB 61 1e-09 5YZG-2 nrPDB 60 1e-09 5LTD-A nrPDB 58 8e-09 2P9P-C nrPDB 58 1e-08 5WLC-LN nrPDB 55 4e-08 5K19-A nrPDB 54 1e-07 5M89-A nrPDB 52 6e-07 5TF2-A nrPDB 52 6e-07 6CVZ-A nrPDB 51 8e-07 3EI3-B nrPDB 50 2e-06 3I2N-A nrPDB 47 1e-05 3JB9-S nrPDB 47 1e-05 2VDU-B nrPDB 45 6e-05 6IYY-A nrPDB 45 1e-04 4FHN-A nrPDB 44 2e-04 6N8P-A nrPDB 43 2e-04 5WLC-LS nrPDB 43 2e-04 5WLC-LH nrPDB 43 2e-04 3DWL-C nrPDB 42 4e-04 3DW8-B nrPDB 42 5e-04 5WLC-LL nrPDB 41 9e-04 2I3T-A nrPDB 41 0.001 4AV8-A nrPDB 38 0.010 4YHC-A nrPDB 36 0.026 5GRS-A nrPDB 33 0.30 3WJ9-A nrPDB 32 0.48 5AMS-A nrPDB 31 0.77 4W84-A nrPDB 31 1.1 6BN7-A nrPDB 30 1.5 5SUM-A nrPDB 30 2.9 3MWP-A nrPDB 29 3.9 5CWW-B nrPDB 29 5.1 1BXK-A nrPDB 28 7.4 >3JZG-A nrPDB Length = 402 Score = 560 bits (1442), Expect = e-160, Method: Composition-based stats. Identities = 402/402 (100%), Positives = 402/402 (100%) Query: 40 DAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGV 99 DAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGV Sbjct: 1 DAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGV 60 Query: 100 QFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTS 159 QFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTS Sbjct: 61 QFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTS 120 Query: 160 HPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWN 219 HPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWN Sbjct: 121 HPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWN 180 Query: 220 IQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 279 IQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD Sbjct: 181 IQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 240 Query: 280 YNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDD 339 YNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDD Sbjct: 241 YNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDD 300 Query: 340 IDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKA 399 IDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKA Sbjct: 301 IDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKA 360 Query: 400 KCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 441 KCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR Sbjct: 361 KCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 402 >5BJS-A nrPDB Length = 605 Score = 245 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 101/336 (30%), Positives = 152/336 (45%), Gaps = 56/336 (16%) Query: 95 PLFGVQFNWHSKEGDPLVFATVGSN-----RVTLYECHSQGEIRLLQSYVDADADENFYT 149 F V+F +S G P VFA R+T ++Q D + N + Sbjct: 79 EFFDVKFYPYSPPGAPPVFAATSKKHAVICRLTQTTDKDANPCEIIQLIRDDGNEANCAS 138 Query: 150 CAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSV 209 C W+ D T PLL +AG+ G +++ N + + VGHG IN+L P +P ++ S Sbjct: 139 C-WSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPANPYIIASA 197 Query: 210 SKDHALRLWNI----QTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI 265 S D +R+W++ + V I GG EGH ++LS + G ++S G D + LW Sbjct: 198 SDDTTIRIWSLAPEHEKQPCVCILGG-EGHSYDLLSVAFHDNGRYVLSAGHDQVINLW-- 254 Query: 266 NSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSC- 324 A+ E PN+ I I++P FS+ +IH N VDCV + GDLILS++C Sbjct: 255 -------ALPEF----PNEHME--IPIVIYYPHFSSSEIHNNLVDCVAFYGDLILSRACH 301 Query: 325 ENAIVCWK-PGKMEDD-----IDKIKPSE-------------------SNVTILGRFDYS 359 E+ IV W+ G DD +D P++ + T L +F Sbjct: 302 EDTIVLWRIEGFSSDDPIPGPLDAPTPTDMTKQTRSYFTPTVSPQSRPAMFTRLAQFHTP 361 Query: 360 QCDI-WYMRFSMDFW---QKMLALGNQVGKLYVWDL 391 C + ++MRF M +LA N K + WDL Sbjct: 362 DCGVQFFMRFRMYHVPGKHPILAFANAKSKTFFWDL 397 Score = 46.5 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 19/125 (15%), Positives = 37/125 (29%), Gaps = 10/125 (8%) Query: 322 KSCENAIVCWKPGKMEDD-IDKIKPSESNVTIL--------GRFDYSQCDIWYMRFSMDF 372 + N CW + D + I +E NV + I + S Sbjct: 131 GNEANCASCWSKDPITDQPLLCIAGNEGNVKVYNVTEGKLYRTLVGHGGGINDLATSPAN 190 Query: 373 WQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDA 432 ++A + + +W L E + L + +F + +++ D Sbjct: 191 PY-IIASASDDTTIRIWSLAPEHEKQPCVCILGGEGHSYDLLSVAFHDNGRYVLSAGHDQ 249 Query: 433 SIWRW 437 I W Sbjct: 250 VINLW 254 >6QX9-5O nrPDB Length = 357 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 64/359 (17%), Positives = 131/359 (36%), Gaps = 62/359 (17%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTL-YECH-SQGEIRLLQSY 138 S + L H ++ +F+ + A+ G +R+ L + + L+ + Sbjct: 54 SLQAPIMLLSGHEGEVYCCKFHPNG-----STLASAGFDRLILLWNVYGDCDNYATLKGH 108 Query: 139 VDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKF 198 A + NT +L A + + + + T + +K GH + +N Sbjct: 109 SGAVMEL---------HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYP 159 Query: 199 HPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDH 258 R P L+ + S D ++LW+I+ + F +VL+ ++ ++I+S G+D+ Sbjct: 160 ARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQN----TYQVLAVTFNDTSDQIISGGIDN 215 Query: 259 SLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDL 318 +K+W + ++ ++ D + G Sbjct: 216 DIKVWDLRQNKLTYTMRGHADSVTG--------------------------LSLSSEGSY 249 Query: 319 ILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTIL-GRFDYSQCDIWYMRFSMDFWQKML 377 +LS + +N + W D+ P E V I G + ++ +S D + Sbjct: 250 LLSNAMDNTVRVW-------DVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD--GSKI 300 Query: 378 ALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWR 436 A G+ +YVWD + L H +I + +F D I+I+ D ++ Sbjct: 301 AAGSADRFVYVWDTT----SRRILYKLPGHA--GSINEVAFHPDEPIIISASSDKRLYM 353 Score = 128 bits (322), Expect = 4e-30, Method: Composition-based stats. Identities = 62/317 (19%), Positives = 105/317 (33%), Gaps = 66/317 (20%) Query: 129 QGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQC--IKHY 186 Q I LL + + Y C + + +T LA AG +I + N C Sbjct: 56 QAPIMLLSGH-----EGEVYCCKFHPNGST----LASAGFDRLILLWNVY-GDCDNYATL 105 Query: 187 VGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDL 246 GH A+ EL ++ D ++L S S D + +W+ +T V ++GH V S Sbjct: 106 KGHSGAVMELHYN-TDGSMLFSASTDKTVAVWDSETGERVKR---LKGHTSFVNSCYPAR 161 Query: 247 LGEKIM-SCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIH 305 G +++ + D ++KLW I K + + +Y Sbjct: 162 RGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQ-------------------------- 195 Query: 306 RNYVDCVRWL--GDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDI 363 V V + D I+S +N I W D+ + K + + Sbjct: 196 ---VLAVTFNDTSDQIISGGIDNDIKVW-------DLRQNK-------LTYTMRGHADSV 238 Query: 364 WYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFS--RD 421 + S + L + VWD+ P + + S D Sbjct: 239 TGLSLSSE--GSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD 296 Query: 422 SSILIAVCDDASIWRWD 438 S + A D ++ WD Sbjct: 297 GSKIAAGSADRFVYVWD 313 >6J6H-n nrPDB Length = 455 Score = 217 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 51/281 (18%), Positives = 107/281 (38%), Gaps = 37/281 (13%) Query: 177 PITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHR 236 + + I++Y GH LKF P+ +L+LS DH +++W+ D +GH Sbjct: 149 YLPKKVIRNYPGHPEGTTALKFLPKTGHLILSGGNDHTIKIWDFYHD--YECLRDFQGHN 206 Query: 237 DEVLSADYDLLGEKIMSCGMDHSLKLWRINSKR-----MMNAIKESYDYNPNKTNRPFI- 290 + + + + +S D S+K+W + + +N+ + P + + Sbjct: 207 KPIKALRFTEDCQSFLSSSFDRSVKIWDTETGKVKTRLHLNSTPADVESRPTNPHEFIVG 266 Query: 291 ---SQKIHFPD--------FSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWKPGKME 337 S+ +H+ D T D H + + +++ G +S S + + W+ Sbjct: 267 LSNSKILHYDDRVSENQGLVQTYDHHLSSILALKYFPDGSKFISSSEDKTVRIWE----- 321 Query: 338 DDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPH 397 ++ NV I D +Q + ++ Q + ++Y + L+ + Sbjct: 322 --------NQINVPIKQISDTAQHSMPFLNVHPS--QNYFCAQSMDNRIYSFSLKPKYKR 371 Query: 398 KAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 K H G I +FS D + + + ++ WD Sbjct: 372 HPKKIFKGHSSAGYGI-SLAFSGDGRYICSGDSKSRLFTWD 411 Score = 84.6 bits (207), Expect = 8e-17, Method: Composition-based stats. Identities = 40/319 (12%), Positives = 89/319 (27%), Gaps = 87/319 (27%) Query: 159 SHPLLAVAGSRGIIRIIN-PITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRL 217 + L+ G+ I+I + +C++ + GH I L+F D LS S D ++++ Sbjct: 174 TGHLILSGGNDHTIKIWDFYHDYECLRDFQGHNKPIKALRFT-EDCQSFLSSSFDRSVKI 232 Query: 218 WNIQTDTLVAIF------------------------------------------GGVEGH 235 W+ +T + + H Sbjct: 233 WDTETGKVKTRLHLNSTPADVESRPTNPHEFIVGLSNSKILHYDDRVSENQGLVQTYDHH 292 Query: 236 RDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIH 295 +L+ Y G K +S D ++++W + N + H Sbjct: 293 LSSILALKYFPDGSKFISSSEDKTVRIW---------------ENQINVPIKQISDTAQH 337 Query: 296 FPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGR 355 F V + ++S +N I + ++ + Sbjct: 338 SMPFLN----------VHPSQNYFCAQSMDNRIYSFS---LKPKYKRHP--------KKI 376 Query: 356 FDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQ 415 F + + + + + G+ +L+ WD + +K I Q Sbjct: 377 FKGHSSAGYGISLAFSGDGRYICSGDSKSRLFTWD--WNTSRLLNNIKIPGNK---PITQ 431 Query: 416 TSFSRDS--SILIAVCDDA 432 + ++ + Sbjct: 432 VDWHPQETSKVICSGAAGK 450 >4BTS-AR nrPDB Length = 343 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 59/307 (19%), Positives = 112/307 (36%), Gaps = 55/307 (17%) Query: 134 LLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQ-------CIKHY 186 +L+ + D ++ N P+L + I + K Sbjct: 16 ILEGHSDWVTSI---VAGFSQKENEDSPVLISGSRDKTVMIWKLYEEEQNGYFGIPHKAL 72 Query: 187 VGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDL 246 GH + +++L ++ +S S D LRLW+++T T F GH+ EV S + Sbjct: 73 TGHNHFVSDLALS-QENCFAISSSWDKTLRLWDLRTGTTYKRFV---GHQSEVYSVAFSP 128 Query: 247 LGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHR 306 +I+S G + +KLW I + ++ + ++ H Sbjct: 129 DNRQILSAGAEREIKLWNILGECKFSSAE--------------------------KENHS 162 Query: 307 NYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDK-IKPSESNVTILGRFDYSQCDIWY 365 ++V CVR+ + N + + P D +K +N I F + ++ + Sbjct: 163 DWVSCVRYSPIM----KSANKVQPFAPYFASVGWDGRLKVWNTNFQIRYTFKAHESNVNH 218 Query: 366 MRFSMDFWQKMLALGNQVGKLYVWD-LEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSI 424 + S + K +A G + KL +WD L + P + G+ I Q +F+ Sbjct: 219 LSISPN--GKYIATGGKDKKLLIWDILNLTYPQR-------EFDAGSTINQIAFNPKLQW 269 Query: 425 LIAVCDD 431 + D Sbjct: 270 VAVGTDQ 276 Score = 76.1 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 25/180 (13%), Positives = 61/180 (33%), Gaps = 13/180 (7%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTC 150 H ++ V F+ +++ + + + L+ + + + +D Sbjct: 116 GHQSEVYSVAFSPDNRQ----ILSAGAEREIKLWNILGECKFSSAEKENHSDWVSCVRYS 171 Query: 151 AWTYDSNTSH---PLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLL 207 +N P A G G +++ N Q + H + +N L P + + Sbjct: 172 PIMKSANKVQPFAPYFASVGWDGRLKVWNT-NFQIRYTFKAHESNVNHLSISP-NGKYIA 229 Query: 208 SVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 267 + KD L +W+I T + ++ + + G D +K++ + + Sbjct: 230 TGGKDKKLLIWDILNLTYPQREFDAG---STINQIAFNPKLQWVA-VGTDQGVKIFNLMT 285 Score = 49.5 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 22/163 (13%), Positives = 50/163 (30%), Gaps = 23/163 (14%) Query: 286 NRPFISQKIHFPDFSTRDIHRNYVDCV--------RWLGDLILSKSCENAIVCWKPGKME 337 S I + H ++V + +++S S + ++ WK + E Sbjct: 1 MADNSSLDIQVVKRGILEGHSDWVTSIVAGFSQKENEDSPVLISGSRDKTVMIWKLYEEE 60 Query: 338 DDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPH 397 + P ++ + + S + + L +WDL + Sbjct: 61 QNGYFGIPHKA-------LTGHNHFVSDLALSQENC--FAISSSWDKTLRLWDLRTGTTY 111 Query: 398 KAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL 440 K + +FS D+ +++ + I W+ L Sbjct: 112 KRFVGHQSEVY------SVAFSPDNRQILSAGAEREIKLWNIL 148 >5M25-A nrPDB Length = 434 Score = 190 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 74/406 (18%), Positives = 152/406 (37%), Gaps = 74/406 (18%) Query: 40 DAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSK----KCKYSFKCVNSLKEDHNQP 95 D + I++ E D N R+ G +SK K Y+ K H + Sbjct: 91 DGIRIQADQTPEDLDMEDNDIIEAHREQIGGSATQSKPTPVKPNYALKFTL---AGHTKA 147 Query: 96 LFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYD 155 + V+F+ + + + ++ + ++ + + + + +D AW+ D Sbjct: 148 VSSVKFSPNGE----WLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV-----AWSSD 198 Query: 156 SNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHAL 215 SN LL A ++I + + +C+K GH N + F+P+ NL++S S D ++ Sbjct: 199 SN----LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESV 253 Query: 216 RLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK 275 R+W+++T + + H D V + ++ G I+S D ++W S + + + Sbjct: 254 RIWDVKTGKCLKT---LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 310 Query: 276 ESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGK 335 + D NP + F G IL+ + +N + W K Sbjct: 311 D--DDNPPVSFVKFSPN-----------------------GKYILAATLDNTLKLWDYSK 345 Query: 336 MEDDIDKIKPSESNVTILGRFDYS--QCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEV 393 L + + + FS+ K + G++ +Y+W+L+ Sbjct: 346 --------------GKCLKTYTGHKNEKYCIFANFSVTG-GKWIVSGSEDNLVYIWNLQT 390 Query: 394 EDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVC--DDASIWRW 437 ++ L H + T+ +I+ + +D +I W Sbjct: 391 KE----IVQKLQGHT--DVVISTACHPTENIIASAALENDKTIKLW 430 Score = 130 bits (325), Expect = 1e-30, Method: Composition-based stats. Identities = 44/188 (23%), Positives = 82/188 (43%), Gaps = 20/188 (10%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 140 + KC+ +L H+ P+ V FN ++G +V S+ L + L++ +D Sbjct: 260 TGKCLKTLPA-HSDPVSAVHFN---RDGSLIV----SSSYDGLCRIWDTASGQCLKTLID 311 Query: 141 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINEL--KF 198 D+N + N + A +++ + +C+K Y GH N + F Sbjct: 312 ---DDNPPVSFVKFSPN--GKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 366 Query: 199 HPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGM-- 256 ++S S+D+ + +WN+QT +V ++GH D V+S I S + Sbjct: 367 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQK---LQGHTDVVISTACHPTENIIASAALEN 423 Query: 257 DHSLKLWR 264 D ++KLW+ Sbjct: 424 DKTIKLWK 431 Score = 95.8 bits (236), Expect = 4e-20, Method: Composition-based stats. Identities = 39/232 (16%), Positives = 69/232 (29%), Gaps = 37/232 (15%) Query: 223 DTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKES----- 277 A+ + GH V S + GE + S D +K+W + I Sbjct: 132 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 191 Query: 278 ---YDYNPNKTNRPFISQKIHFPDFS------TRDIHRNYVDCVRWLG--DLILSKSCEN 326 + + N + + D S T H NYV C + +LI+S S + Sbjct: 192 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 251 Query: 327 AIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKL 386 ++ W L + + F+ D ++ + G Sbjct: 252 SVRIWD--------------VKTGKCLKTLPAHSDPVSAVHFNRD--GSLIVSSSYDGLC 295 Query: 387 YVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 +WD K + FS + ++A D ++ WD Sbjct: 296 RIWDTASGQCLKTLID-----DDNPPVSFVKFSPNGKYILAATLDNTLKLWD 342 Score = 30.3 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 11/48 (22%), Positives = 15/48 (31%), Gaps = 2/48 (4%) Query: 392 EVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDR 439 P+ A TL H + FS + L + D I W Sbjct: 129 TPVKPNYALKFTLAGHTKA--VSSVKFSPNGEWLASSSADKLIKIWGA 174 >1VYH-C nrPDB Length = 410 Score = 184 bits (467), Expect = 6e-47, Method: Composition-based stats. Identities = 62/355 (17%), Positives = 124/355 (34%), Gaps = 57/355 (16%) Query: 90 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYT 149 H P+ V F+ ++ + + +++ + R L+ + D+ D +F Sbjct: 105 SGHRSPVTRVIFHPVFS----VMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISF-- 158 Query: 150 CAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSV 209 + S LLA + I++ + +CI+ GH + ++ + P + + ++S Sbjct: 159 -------DHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMP-NGDHIVSA 210 Query: 210 SKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKR 269 S+D +++W +QT V F GHR+ V + G I SC D ++++W + +K Sbjct: 211 SRDKTIKMWEVQTGYCVKTFT---GHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKE 267 Query: 270 MMNAIKES------YDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKS 323 ++E + P + S + G +LS S Sbjct: 268 CKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKP------------GPFLLSGS 315 Query: 324 CENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQV 383 + I W S L + + F K + Sbjct: 316 RDKTIKMWD--------------VSTGMCLMTLVGHDNWVRGVLFHS--GGKFILSCADD 359 Query: 384 GKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 L VWD +K TL H+ + F + + ++ D ++ W+ Sbjct: 360 KTLRVWD----YKNKRCMKTLNAHE--HFVTSLDFHKTAPYVVTGSVDQTVKVWE 408 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 55/277 (19%), Positives = 100/277 (36%), Gaps = 34/277 (12%) Query: 184 KHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSAD 243 GH + + + FHP +++S S+D +++W+ +T ++GH D V Sbjct: 102 YALSGHRSPVTRVIFHPVFS-VMVSASEDATIKVWDYETGDFERT---LKGHTDSVQDIS 157 Query: 244 YDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKES------YDYNPNKTNRPFIS--QKIH 295 +D G+ + SC D ++KLW + + PN + S + I Sbjct: 158 FDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVSIMPNGDHIVSASRDKTIK 217 Query: 296 FPDFS------TRDIHRNYVDCVR--WLGDLILSKSCENAIVCW--KPGKMEDDIDKIKP 345 + T HR +V VR G LI S S + + W + + ++ + + Sbjct: 218 MWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHRH 277 Query: 346 SESNVTILGRFDYSQCDIWYMRFS----MDFWQKMLALGNQVGKLYVWDLEVEDPHKAKC 401 I + S I S L G++ + +WD+ Sbjct: 278 VVEC--ISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVST----GMCL 331 Query: 402 TTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 TL H +R F +++ DD ++ WD Sbjct: 332 MTLVGHDNW--VRGVLFHSGGKFILSCADDKTLRVWD 366 Score = 79.6 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 21/156 (13%), Positives = 57/156 (36%), Gaps = 19/156 (12%) Query: 75 SKKCK-------YSFKCVNSLKEDHNQPLFGVQFNWHSKEGDP-LVFATVGSNR-VTLYE 125 +K+CK + +C++ E + + K G P + ++ + +++ Sbjct: 265 TKECKAELREHRHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWD 324 Query: 126 CHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKH 185 + + L + + F ++ + +R+ + +C+K Sbjct: 325 VSTGMCLMTLVGHDNWVRGVLF---------HSGGKFILSCADDKTLRVWDYKNKRCMKT 375 Query: 186 YVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221 H + + L FH P +++ S D +++W + Sbjct: 376 LNAHEHFVTSLDFHKTAP-YVVTGSVDQTVKVWECR 410 >6MZM-G nrPDB Length = 800 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 52/224 (23%), Positives = 99/224 (44%), Gaps = 21/224 (9%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRV-TLYECHSQGEIRLLQSYV 139 +F C+ K HN P++ QF+ + F + G +RV L+ +R+ ++ Sbjct: 574 TFTCLVGYK-GHNYPVWDTQFSPYG-----YYFVSGGHDRVARLWATDHYQPLRIFAGHL 627 Query: 140 DADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFH 199 AD N + N++ +A + +R+ + + C++ + GH I+ L F Sbjct: 628 ---ADVNCTR----FHPNSN--YVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFS 678 Query: 200 PRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHS 259 P + L + + D + LW+I +V G ++GH D V S + GE + S MD++ Sbjct: 679 P-NGRFLATGATDGRVLLWDIGHGLMV---GELKGHTDTVCSLRFSRDGEILASGSMDNT 734 Query: 260 LKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRD 303 ++LW K + + + N P SQ++ + T+ Sbjct: 735 VRLWD-AIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKS 777 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 59/258 (22%), Positives = 91/258 (35%), Gaps = 52/258 (20%) Query: 184 KHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSAD 243 K GH + F P D N LLS S+D +RLW++QT T G +GH V Sbjct: 537 KILYGHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQTFTC---LVGYKGHNYPVWDTQ 592 Query: 244 YDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRD 303 + G +S G D +LW + + R F H D + Sbjct: 593 FSPYGYYFVSGGHDRVARLWATDHYQ---------------PLRIFAG---HLADVNCTR 634 Query: 304 IHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDI 363 H N + + + S + + W N + F + I Sbjct: 635 FHPNS--------NYVATGSADRTVRLWD--------------VLNGNCVRIFTGHKGPI 672 Query: 364 WYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSS 423 + FS + + LA G G++ +WD+ H L H + FSRD Sbjct: 673 HSLTFSPN--GRFLATGATDGRVLLWDI----GHGLMVGELKGHT--DTVCSLRFSRDGE 724 Query: 424 ILIAVCDDASIWRWDRLR 441 IL + D ++ WD ++ Sbjct: 725 ILASGSMDNTVRLWDAIK 742 Score = 148 bits (372), Expect = 6e-36, Method: Composition-based stats. Identities = 46/253 (18%), Positives = 92/253 (36%), Gaps = 47/253 (18%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTC 150 H+ P++G F+ + ++ V L+ + + + + N+ Sbjct: 541 GHSGPVYGASFSPDRN----YLLSSSEDGTVRLWSLQTFTCLVGYKGH-------NYPV- 588 Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS 210 W + G + R+ Q ++ + GH +N +FHP + N + + S Sbjct: 589 -WDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHP-NSNYVATGS 646 Query: 211 KDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRM 270 D +RLW++ V IF GH+ + S + G + + D + LW I M Sbjct: 647 ADRTVRLWDVLNGNCVRIFT---GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLM 703 Query: 271 MNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL--GDLILSKSCENAI 328 + +K H + V +R+ G+++ S S +N + Sbjct: 704 VGELK----------------------------GHTDTVCSLRFSRDGEILASGSMDNTV 735 Query: 329 VCWKPGKMEDDID 341 W K +D++ Sbjct: 736 RLWDAIKAFEDLE 748 >6F3T-A nrPDB Length = 608 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 52/224 (23%), Positives = 99/224 (44%), Gaps = 21/224 (9%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRV-TLYECHSQGEIRLLQSYV 139 +F C+ K HN P++ QF+ + F + G +RV L+ +R+ ++ Sbjct: 382 TFTCLVGYK-GHNYPVWDTQFSPYG-----YYFVSGGHDRVARLWATDHYQPLRIFAGHL 435 Query: 140 DADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFH 199 AD N + N++ +A + +R+ + + C++ + GH I+ L F Sbjct: 436 ---ADVNCTR----FHPNSN--YVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFS 486 Query: 200 PRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHS 259 P + L + + D + LW+I +V G ++GH D V S + GE + S MD++ Sbjct: 487 P-NGRFLATGATDGRVLLWDIGHGLMV---GELKGHTDTVCSLRFSRDGEILASGSMDNT 542 Query: 260 LKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRD 303 ++LW K + + + N P SQ++ + T+ Sbjct: 543 VRLWD-AIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKS 585 Score = 162 bits (409), Expect = 3e-40, Method: Composition-based stats. Identities = 53/312 (16%), Positives = 102/312 (32%), Gaps = 53/312 (16%) Query: 146 NFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNL 205 N Y D L+A + +R+ + + D +L Sbjct: 276 NAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQA------------SDLSL 323 Query: 206 LLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI 265 + S D R+ + +T + + I + GH V A + ++S D +++LW + Sbjct: 324 IDKESDDVLERIMDEKTASELKI---LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 380 Query: 266 NSKRMMNAIKES------YDYNP--------NKTNRPFISQKIHFPDFSTRDIHRNYVDC 311 + + K ++P + H+ H V+C Sbjct: 381 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNC 440 Query: 312 VRWLG--DLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFS 369 R+ + + + S + + W N + F + I + FS Sbjct: 441 TRFHPNSNYVATGSADRTVRLWD--------------VLNGNCVRIFTGHKGPIHSLTFS 486 Query: 370 MDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVC 429 + + LA G G++ +WD+ H L H + FSRD IL + Sbjct: 487 PN--GRFLATGATDGRVLLWDI----GHGLMVGELKGHT--DTVCSLRFSRDGEILASGS 538 Query: 430 DDASIWRWDRLR 441 D ++ WD ++ Sbjct: 539 MDNTVRLWDAIK 550 Score = 148 bits (372), Expect = 6e-36, Method: Composition-based stats. Identities = 46/253 (18%), Positives = 92/253 (36%), Gaps = 47/253 (18%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTC 150 H+ P++G F+ + ++ V L+ + + + + N+ Sbjct: 349 GHSGPVYGASFSPDRN----YLLSSSEDGTVRLWSLQTFTCLVGYKGH-------NYPV- 396 Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS 210 W + G + R+ Q ++ + GH +N +FHP + N + + S Sbjct: 397 -WDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHP-NSNYVATGS 454 Query: 211 KDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRM 270 D +RLW++ V IF GH+ + S + G + + D + LW I M Sbjct: 455 ADRTVRLWDVLNGNCVRIFT---GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLM 511 Query: 271 MNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL--GDLILSKSCENAI 328 + +K H + V +R+ G+++ S S +N + Sbjct: 512 VGELK----------------------------GHTDTVCSLRFSRDGEILASGSMDNTV 543 Query: 329 VCWKPGKMEDDID 341 W K +D++ Sbjct: 544 RLWDAIKAFEDLE 556 >2H9P-A nrPDB Length = 329 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 62/352 (17%), Positives = 134/352 (38%), Gaps = 67/352 (19%) Query: 90 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYT 149 H + + V+F+ + + + ++ + ++ + + + + +D Sbjct: 37 AGHTKAVSSVKFSPNGE----WLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV---- 88 Query: 150 CAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSV 209 AW+ DSN LL A ++I + + +C+K GH N + F+P+ NL++S Sbjct: 89 -AWSSDSN----LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS-NLIVSG 142 Query: 210 SKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKR 269 S D ++R+W+++T + + H D V + ++ G I+S D ++W S + Sbjct: 143 SFDESVRIWDVKTGKCLKT---LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 199 Query: 270 MMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIV 329 + + + D NP + F G IL+ + +N + Sbjct: 200 CLKTLID--DDNPPVSFVKFSPN-----------------------GKYILAATLDNTLK 234 Query: 330 CWKPGKMEDDIDKIKPSESNVTILGRFDYS--QCDIWYMRFSMDFWQKMLALGNQVGKLY 387 W K L + + + FS+ K + G++ +Y Sbjct: 235 LWDYSK--------------GKCLKTYTGHKNEKYCIFANFSVTG-GKWIVSGSEDNLVY 279 Query: 388 VWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVC--DDASIWRW 437 +W+L+ ++ L H + T+ +I+ + +D +I W Sbjct: 280 IWNLQTKE----IVQKLQGHT--DVVISTACHPTENIIASAALENDKTIKLW 325 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 44/188 (23%), Positives = 82/188 (43%), Gaps = 20/188 (10%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 140 + KC+ +L H+ P+ V FN ++G +V S+ L + L++ +D Sbjct: 155 TGKCLKTLPA-HSDPVSAVHFN---RDGSLIV----SSSYDGLCRIWDTASGQCLKTLID 206 Query: 141 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINEL--KF 198 D+N + N + A +++ + +C+K Y GH N + F Sbjct: 207 ---DDNPPVSFVKFSPN--GKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 261 Query: 199 HPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGM-- 256 ++S S+D+ + +WN+QT +V ++GH D V+S I S + Sbjct: 262 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQK---LQGHTDVVISTACHPTENIIASAALEN 318 Query: 257 DHSLKLWR 264 D ++KLW+ Sbjct: 319 DKTIKLWK 326 Score = 111 bits (278), Expect = 4e-25, Method: Composition-based stats. Identities = 41/202 (20%), Positives = 93/202 (46%), Gaps = 22/202 (10%) Query: 83 KCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDAD 142 KC+ +LK H+ +F FN S + +V + V +++ + ++ L ++ D Sbjct: 115 KCLKTLK-GHSNYVFCCNFNPQS---NLIVSGSFD-ESVRIWDVKTGKCLKTLPAHSDPV 169 Query: 143 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNA-INELKFHPR 201 + +F N L+ + G+ RI + + QC+K + N ++ +KF P Sbjct: 170 SAVHF---------NRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP- 219 Query: 202 DPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSA--DYDLL-GEKIMSCGMDH 258 + +L+ + D+ L+LW+ + + GH++E ++ + G+ I+S D+ Sbjct: 220 NGKYILAATLDNTLKLWDYSKGKCLKTYT---GHKNEKYCIFANFSVTGGKWIVSGSEDN 276 Query: 259 SLKLWRINSKRMMNAIKESYDY 280 + +W + +K ++ ++ D Sbjct: 277 LVYIWNLQTKEIVQKLQGHTDV 298 Score = 92.7 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 38/232 (16%), Positives = 69/232 (29%), Gaps = 37/232 (15%) Query: 223 DTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKES----- 277 A+ + GH V S + GE + S D +K+W + I Sbjct: 27 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 86 Query: 278 ---YDYNPNKTNRPFISQKIHFPDFST------RDIHRNYVDCVRWLG--DLILSKSCEN 326 + + N + + D S+ H NYV C + +LI+S S + Sbjct: 87 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 146 Query: 327 AIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKL 386 ++ W L + + F+ D ++ + G Sbjct: 147 SVRIWD--------------VKTGKCLKTLPAHSDPVSAVHFNRD--GSLIVSSSYDGLC 190 Query: 387 YVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 +WD K + FS + ++A D ++ WD Sbjct: 191 RIWDTASGQCLKTLID-----DDNPPVSFVKFSPNGKYILAATLDNTLKLWD 237 Score = 29.5 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 11/48 (22%), Positives = 15/48 (31%), Gaps = 2/48 (4%) Query: 392 EVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDR 439 P+ A TL H + FS + L + D I W Sbjct: 24 TPVKPNYALKFTLAGHTKA--VSSVKFSPNGEWLASSSADKLIKIWGA 69 >4V8M-A7 nrPDB Length = 318 Score = 179 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 62/305 (20%), Positives = 106/305 (34%), Gaps = 72/305 (23%) Query: 149 TCAWTYDSNTSHPLLAVAGSRGIIRIINPIT---------MQCIKHYVGHGNAINELKFH 199 T + + + + P + GH ++++ Sbjct: 17 TSLACPQTPETATKVVSTSRDKTLLSWGPNPDRHSSECSYGLPDRRLEGHSAFVSDVALS 76 Query: 200 PRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHS 259 + N +S S DH+LRLWN+Q F GH +VLS + +I+S G D++ Sbjct: 77 -NNGNFAVSASWDHSLRLWNLQNGQCQYKF---LGHTKDVLSVAFSPDNRQIVSGGRDNA 132 Query: 260 LKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDL- 318 L++W + + M +R H ++V CVR+ L Sbjct: 133 LRVWNVKGECM---------------------------HTLSRGAHTDWVSCVRFSPSLD 165 Query: 319 ---ILSKSCENAIVCW--KPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFW 373 I+S +N + W G++ D+ ++VT+ D S C Sbjct: 166 APVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYVTSVTV--SPDGSLC------------ 211 Query: 374 QKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDAS 433 A ++ G +WDL K L+ GA I Q FS + + A + Sbjct: 212 ----ASSDKDGVARLWDL-------TKGEALSEMAAGAPINQICFSPNRYWMCAA-TEKG 259 Query: 434 IWRWD 438 I +D Sbjct: 260 IRIFD 264 Score = 125 bits (312), Expect = 5e-29, Method: Composition-based stats. Identities = 49/287 (17%), Positives = 98/287 (34%), Gaps = 45/287 (15%) Query: 73 WKSKKCKYSFKCVNSLK----EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHS 128 W ++S +C L E H+ + V S G+ V A+ + L+ + Sbjct: 43 WGPNPDRHSSECSYGLPDRRLEGHSAFVSDVAL---SNNGNFAVSASWDH-SLRLWNLQN 98 Query: 129 QGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYV- 187 + F + + + G +R+ N +C+ Sbjct: 99 GQCQYKFLGHTKDVLSVAF---------SPDNRQIVSGGRDNALRVWNV-KGECMHTLSR 148 Query: 188 -GHGNAINELKFHPR-DPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYD 245 H + ++ ++F P D +++S D+ +++W++ T LV ++GH + V S Sbjct: 149 GAHTDWVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVT---DLKGHTNYVTSVTVS 205 Query: 246 LLGEKIMSCGMDHSLKLWRINSKRMMNAIK-----ESYDYNPNKT-NRPFISQKIHFPDF 299 G S D +LW + ++ + ++PN+ + I D Sbjct: 206 PDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSPNRYWMCAATEKGIRIFDL 265 Query: 300 STRDI-------HRNY------VDCVRWL--GDLILSKSCENAIVCW 331 +DI H+ + W G + S +N I W Sbjct: 266 ENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVW 312 Score = 83.8 bits (205), Expect = 1e-16, Method: Composition-based stats. Identities = 30/237 (12%), Positives = 79/237 (33%), Gaps = 62/237 (26%) Query: 74 KSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIR 133 ++ +C+Y F H + + V F+ +++ + + N + ++ + Sbjct: 97 QNGQCQYKF-------LGHTKDVLSVAFSPDNRQ----IVSGGRDNALRVWNV----KGE 141 Query: 134 LLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAI 193 + + + + + + P++ G ++++ + T + + GH N + Sbjct: 142 CMHTLSRGAHTD--WVSCVRFSPSLDAPVIVSGGWDNLVKVWDLATGRLVTDLKGHTNYV 199 Query: 194 NELKFHPRDPNLLLSVSKDHALRLWNIQTDT----------------------------- 224 + P D +L S KD RLW++ Sbjct: 200 TSVTVSP-DGSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSPNRYWMCAATEK 258 Query: 225 ------------LVAIFGGVEGHRDEV---LSADYDLLGEKIMSCGMDHSLKLWRIN 266 +V + +G + V +S + G + S D+ +++W ++ Sbjct: 259 GIRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDNVIRVWGVS 315 Score = 44.9 bits (104), Expect = 7e-05, Method: Composition-based stats. Identities = 24/190 (12%), Positives = 57/190 (30%), Gaps = 60/190 (31%) Query: 83 KCVNSLKED-HNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDA 141 +C+++L H + V+F+ P++ + N V +++ + + L+ + + Sbjct: 141 ECMHTLSRGAHTDWVSCVRFSPSLD--APVIVSGGWDNLVKVWDLATGRLVTDLKGHTNY 198 Query: 142 DADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPR 201 + L A + G+ R+ + + + G IN++ F P Sbjct: 199 VTSVTV---------SPDGSLCASSDKDGVARLWDLTKGEALSEMAA-GAPINQICFSPN 248 Query: 202 -----------------------------------------------DPNLLLSVSKDHA 214 D + L S D+ Sbjct: 249 RYWMCAATEKGIRIFDLENKDIIVELAPEHQGSKKIVPECVSIAWSADGSTLYSGYTDNV 308 Query: 215 LRLWNIQTDT 224 +R+W + + Sbjct: 309 IRVWGVSENA 318 >5MZH-A nrPDB Length = 452 Score = 179 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 43/187 (22%), Positives = 86/187 (45%), Gaps = 18/187 (9%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 140 + +CV+ L H + QFN+ G +V ++ L++ S + + Q + D Sbjct: 252 TGQCVHVLS-GHRGEVSSTQFNY---AGTLVVSGSIDCTS-RLWDVRSGRCLSVKQGHTD 306 Query: 141 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP 200 D F + + + A + G R+ + +T C VGH I+++ F+P Sbjct: 307 EVLDVAF---------DAAGTKMVSASADGSARLYHTLTGVCQHTLVGHEGEISKVAFNP 357 Query: 201 RDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSL 260 + L+ + S D RLW+ T + + +EGH DE+ S ++ G+ I++ D++ Sbjct: 358 QGTRLI-TASSDKTCRLWDCDTGECLQV---LEGHTDEIFSCAFNYEGDFIITGSKDNTC 413 Query: 261 KLWRINS 267 ++W+ + Sbjct: 414 RIWKALT 420 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 63/378 (16%), Positives = 125/378 (33%), Gaps = 57/378 (15%) Query: 80 YSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRV-TLYECHSQGEIRLLQSY 138 +SF L+ H PL FN F T +R ++ + E+ L+ + Sbjct: 82 HSFTLFKVLRA-HILPLTNCAFNKSGDR-----FITGSYDRTCKVWNTFTGEEVFTLEGH 135 Query: 139 VDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKF 198 + F +N + ++ + T Q GH I L F Sbjct: 136 KNVVYAIAF--------NNPYGDKIVTGSFDKTCKLWDAYTGQLYYTLKGHQTEIVCLSF 187 Query: 199 HPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDH 258 +P+ ++ + S D+ +LW+++T A + GHR E++S ++ G+ I++ DH Sbjct: 188 NPQST-IIATGSMDNTAKLWDVETGQERAT---LAGHRAEIVSLGFNTGGDLIVTGSFDH 243 Query: 259 SLKLWRINSKRMMNAIKES--------YDYNPNKTNRPFISQKIHFPDF------STRDI 304 +LW + + + ++ + ++Y I D S + Sbjct: 244 DSRLWDVRTGQCVHVLSGHRGEVSSTQFNYAGTLVVSGSIDCTSRLWDVRSGRCLSVKQG 303 Query: 305 HRNYVDCVRW--LGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCD 362 H + V V + G ++S S + + + + + Sbjct: 304 HTDEVLDVAFDAAGTKMVSASADGSARLY--------------HTLTGVCQHTLVGHEGE 349 Query: 363 IWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDS 422 I + F+ L + +WD + L H I +F+ + Sbjct: 350 ISKVAFNP--QGTRLITASSDKTCRLWDCDT----GECLQVLEGHT--DEIFSCAFNYEG 401 Query: 423 SILIAVCDDASIWRWDRL 440 +I D + W L Sbjct: 402 DFIITGSKDNTCRIWKAL 419 Score = 92.7 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 30/221 (13%), Positives = 66/221 (29%), Gaps = 53/221 (23%) Query: 221 QTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDY 280 Q +F + H + + ++ G++ ++ D + K+W + + + Sbjct: 79 QQHHSFTLFKVLRAHILPLTNCAFNKSGDRFITGSYDRTCKVWNTFTGEEVFTL------ 132 Query: 281 NPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW---LGDLILSKSCENAIVCWKPGKME 337 + H+N V + + GD I++ S + W Sbjct: 133 ----------------------EGHKNVVYAIAFNNPYGDKIVTGSFDKTCKLWDAY--- 167 Query: 338 DDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPH 397 + Q +I + F+ ++A G+ +WD+E Sbjct: 168 -----------TGQLYYTLKGHQTEIVCLSFNPQST--IIATGSMDNTAKLWDVETGQER 214 Query: 398 KAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 L H+ I F+ +++ D WD Sbjct: 215 AT----LAGHRA--EIVSLGFNTGGDLIVTGSFDHDSRLWD 249 >5OPT-p nrPDB Length = 318 Score = 179 bits (453), Expect = 3e-45, Method: Composition-based stats. Identities = 60/300 (20%), Positives = 107/300 (35%), Gaps = 72/300 (24%) Query: 154 YDSNTSHPLLAVAGSRGIIRII----NPITMQCI-----KHYVGHGNAINELKFHPRDPN 204 ++ + + + +C + GH ++++ + + Sbjct: 22 PQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHSAFVSDVALS-NNGD 80 Query: 205 LLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 +S S DH+LRLWN+QT F GH +VLS + +I+S G D++L++W Sbjct: 81 FAVSASWDHSLRLWNLQTGVCQHKF---LGHTKDVLSVTFSPDNRQIVSGGRDNALRVWN 137 Query: 265 INSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGD----LIL 320 + + + R H ++V CVR+ LI+ Sbjct: 138 VKGECL---------------------------HTLGRGAHTDWVSCVRFSPSLETPLIV 170 Query: 321 SKSCENAIVCW--KPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLA 378 S +N + W G++ D+ ++VT+ D S C A Sbjct: 171 SGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTV--SPDGSLC----------------A 212 Query: 379 LGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 ++ G +WDL K L+ GA I Q FS + + A + I +D Sbjct: 213 SSDKDGVARLWDL-------TKGEALSEMAAGAPINQICFSPNRYWMCAA-TEKGIRIFD 264 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 45/291 (15%), Positives = 97/291 (33%), Gaps = 44/291 (15%) Query: 67 SWGKGKWK-SKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYE 125 +WG + S++C+Y F E H+ + V S GD V A+ + L+ Sbjct: 42 AWGSNMDRNSEECEYGFP--ERRLEGHSAFVSDVAL---SNNGDFAVSASWDH-SLRLWN 95 Query: 126 CHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKH 185 + + F + + + G +R+ N +C+ Sbjct: 96 LQTGVCQHKFLGHTKDVLSVTF---------SPDNRQIVSGGRDNALRVWNV-KGECLHT 145 Query: 186 Y--VGHGNAINELKFHPR-DPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSA 242 H + ++ ++F P + L++S D+ +++W+I + + ++GH + + S Sbjct: 146 LGRGAHTDWVSCVRFSPSLETPLIVSGGWDNLVKVWDIASG---RLLTDLKGHTNYITSV 202 Query: 243 DYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK-----ESYDYNPNK------------- 284 G S D +LW + ++ + ++PN+ Sbjct: 203 TVSPDGSLCASSDKDGVARLWDLTKGEALSEMAAGAPINQICFSPNRYWMCAATEKGIRI 262 Query: 285 -TNRPFISQKIHFPDFSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWK 332 P+ + + W G+ + S +N I W Sbjct: 263 FDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGNTLYSGYTDNVIRVWS 313 Score = 105 bits (262), Expect = 3e-23, Method: Composition-based stats. Identities = 47/269 (17%), Positives = 78/269 (28%), Gaps = 61/269 (22%) Query: 185 HYVGHGNAINELKFHPRDPNLL--LSVSKDHALRLW----NIQTDTLVAIFGG--VEGHR 236 GH + L + +S S+D+ L W + ++ F +EGH Sbjct: 8 QLKGHRGWVTALACPQITETYIKAVSTSRDNTLIAWGSNMDRNSEECEYGFPERRLEGHS 67 Query: 237 DEVLSADYDLLGEKIMSCGMDHSLKLWRINSK----RMMNAIKESYDYNPNKTNRPFISQ 292 V G+ +S DHSL+LW + + + + K+ + NR Sbjct: 68 AFVSDVALSNNGDFAVSASWDHSLRLWNLQTGVCQHKFLGHTKDVLSVTFSPDNRQ---- 123 Query: 293 KIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTI 352 I+S +NA+ W V+ Sbjct: 124 --------------------------IVSGGRDNALRVWNVKGECLHTLGRGAHTDWVSC 157 Query: 353 LGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAA 412 + RFS ++ G + VWD+ T L H Sbjct: 158 V-------------RFSPSLETPLIVSGGWDNLVKVWDI----ASGRLLTDLKGHT--NY 198 Query: 413 IRQTSFSRDSSILIAVCDDASIWRWDRLR 441 I + S D S+ + D WD + Sbjct: 199 ITSVTVSPDGSLCASSDKDGVARLWDLTK 227 Score = 81.5 bits (199), Expect = 7e-16, Method: Composition-based stats. Identities = 28/220 (12%), Positives = 70/220 (31%), Gaps = 55/220 (25%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTC 150 H + + V F+ +++ + + N + ++ + L + + + Sbjct: 107 GHTKDVLSVTFSPDNRQ----IVSGGRDNALRVWNV----KGECLHTLGRGAHTD--WVS 156 Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS 210 + + PL+ G ++++ + + + + GH N I + P D +L S Sbjct: 157 CVRFSPSLETPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNYITSVTVSP-DGSLCASSD 215 Query: 211 KDHALRLWNIQTDTLVA--------------------IFGGVEGH--------------- 235 KD RLW++ ++ +G Sbjct: 216 KDGVARLWDLTKGEALSEMAAGAPINQICFSPNRYWMCAATEKGIRIFDLENKDVIVELA 275 Query: 236 ---------RDEVLSADYDLLGEKIMSCGMDHSLKLWRIN 266 E +S + G + S D+ +++W ++ Sbjct: 276 PEAQQKSKKTPECMSIAWSADGNTLYSGYTDNVIRVWSVS 315 Score = 49.9 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 28/190 (14%), Positives = 60/190 (31%), Gaps = 60/190 (31%) Query: 83 KCVNSLKED-HNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDA 141 +C+++L H + V+F+ + PL+ + N V +++ S + L+ + + Sbjct: 141 ECLHTLGRGAHTDWVSCVRFSPSLE--TPLIVSGGWDNLVKVWDIASGRLLTDLKGHTNY 198 Query: 142 DADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPR 201 + + D L A + G+ R+ + + + G IN++ F P Sbjct: 199 -----ITSVTVSPDG----SLCASSDKDGVARLWDLTKGEALSEMAA-GAPINQICFSPN 248 Query: 202 -----------------------------------------------DPNLLLSVSKDHA 214 D N L S D+ Sbjct: 249 RYWMCAATEKGIRIFDLENKDVIVELAPEAQQKSKKTPECMSIAWSADGNTLYSGYTDNV 308 Query: 215 LRLWNIQTDT 224 +R+W++ Sbjct: 309 IRVWSVSEHA 318 >5NNZ-B nrPDB Length = 415 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 67/379 (17%), Positives = 135/379 (35%), Gaps = 57/379 (15%) Query: 76 KKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRV-TLYECHSQGEIRL 134 + ++F LK H PL V N F T +R L++ S E+ Sbjct: 76 QNSNHTFYLFKVLKA-HILPLTNVALNK-----SGSCFITGSYDRTCKLWDTASGEELNT 129 Query: 135 LQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAIN 194 L+ + + F +N +A ++ + T +C + GH I Sbjct: 130 LEGHRNVVYAIAF--------NNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIV 181 Query: 195 ELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSC 254 L F+P+ L+ + S D +LW+IQ V + GH E++S ++ G++I++ Sbjct: 182 CLSFNPQST-LVATGSMDTTAKLWDIQNGEEVYT---LRGHSAEIISLSFNTSGDRIITG 237 Query: 255 GMDHSLKLWRINSKRMMNAIKES--------YDYNPNKTNRPFISQKIHFPD------FS 300 DH++ +W ++ R +N + ++++ + + + D + Sbjct: 238 SFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVA 297 Query: 301 TRDIHRNYV--DCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDY 358 T H + + C + G LI + S + + + + + Sbjct: 298 TLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATR--------------KCIAKLEG 343 Query: 359 SQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSF 418 + +I + F+ L G+ +WD + L H I +F Sbjct: 344 HEGEISKISFNP--QGNHLLTGSSDKTARIWDAQT----GQCLQVLEGHT--DEIFSCAF 395 Query: 419 SRDSSILIAVCDDASIWRW 437 + +I+I D + W Sbjct: 396 NYKGNIVITGSKDNTCRIW 414 Score = 164 bits (414), Expect = 8e-41, Method: Composition-based stats. Identities = 48/299 (16%), Positives = 98/299 (32%), Gaps = 41/299 (13%) Query: 157 NTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALR 216 N S ++ + + + + GH N + + F+ + + + S D + Sbjct: 101 NKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCK 160 Query: 217 LWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE 276 LW+++T F GH E++ ++ + + MD + KLW I + + ++ Sbjct: 161 LWSVETGKCYHTF---RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRG 217 Query: 277 S----YDYNPNKTNRPFIS----QKIHFPDFSTRD------IHRNYVDCV--RWLGDLIL 320 + N + I+ + D T H + W LIL Sbjct: 218 HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLIL 277 Query: 321 SKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALG 380 + S + W +N + +I F D+ K++A Sbjct: 278 TGSMDKTCKLWDA--------------TNGKCVATLTGHDDEILDSCF--DYTGKLIATA 321 Query: 381 NQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDR 439 + G ++ + L H+ I + SF+ + L+ D + WD Sbjct: 322 SADGTARIFS----AATRKCIAKLEGHE--GEISKISFNPQGNHLLTGSSDKTARIWDA 374 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 45/301 (14%), Positives = 98/301 (32%), Gaps = 86/301 (28%) Query: 76 KKCKY----SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVT-LYECHSQG 130 K CK + KC ++ + H + + FN S + AT + L++ + Sbjct: 157 KTCKLWSVETGKCYHTFR-GHTAEIVCLSFNPQST-----LVATGSMDTTAKLWDIQNGE 210 Query: 131 EIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHG 190 E+ L+ + +F NTS + + + + T + + +GH Sbjct: 211 EVYTLRGHSAEIISLSF---------NTSGDRIITGSFDHTVVVWDADTGRKVNILIGHC 261 Query: 191 NAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGG------------------- 231 I+ F+ D +L+L+ S D +LW+ VA G Sbjct: 262 AEISSASFN-WDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIAT 320 Query: 232 --------------------VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMM 271 +EGH E+ ++ G +++ D + ++W + + + Sbjct: 321 ASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380 Query: 272 NAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCW 331 ++ D + + G+++++ S +N W Sbjct: 381 QVLEGHTDEIFSC--------------------------AFNYKGNIVITGSKDNTCRIW 414 Query: 332 K 332 + Sbjct: 415 R 415 Score = 95.4 bits (235), Expect = 4e-20, Method: Composition-based stats. Identities = 42/264 (15%), Positives = 84/264 (31%), Gaps = 61/264 (23%) Query: 187 VGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ--------TDTLVAIFGGVEGHRDE 238 +G ++ L + LL+ S+ ++L + ++ +F ++ H Sbjct: 35 LGPSTDVSALVEEIQKAEPLLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILP 94 Query: 239 VLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPD 298 + + + G ++ D + KLW S +N + Sbjct: 95 LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTL------------------------ 130 Query: 299 FSTRDIHRNYVDCVRW---LGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGR 355 + HRN V + + GD I + S + W S Sbjct: 131 ----EGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW--------------SVETGKCYHT 172 Query: 356 FDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQ 415 F +I + F+ ++A G+ +WD++ + + TL H I Sbjct: 173 FRGHTAEIVCLSFNPQST--LVATGSMDTTAKLWDIQ----NGEEVYTLRGHSA--EIIS 224 Query: 416 TSFSRDSSILIAVCDDASIWRWDR 439 SF+ +I D ++ WD Sbjct: 225 LSFNTSGDRIITGSFDHTVVVWDA 248 >3JB9-g nrPDB Length = 558 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 52/280 (18%), Positives = 105/280 (37%), Gaps = 36/280 (12%) Query: 177 PITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHR 236 I + I + GH I+ L+F P +LLLS S D+ +++W + D ++ +GH Sbjct: 253 YIPKKHIFTWKGHTKGISCLRFFPISGHLLLSGSMDNQIKIWEVYHDR--SLLRTFQGHA 310 Query: 237 DEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKES-------YDYNPNKTN--- 286 + + G +S D ++KLW + +N + +P+K N Sbjct: 311 RPIRDLSFSQDGRSFLSTSFDKTIKLWDTELGKCLNCFNSDRLTNCVKFQVDPDKPNEFL 370 Query: 287 -----RPFISQKIHFPD-FSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWKPGKMED 338 + + I PD D H ++ + +L G ++ S ++++ W+ G Sbjct: 371 AGTADKRILQFDIRSPDIVQAYDHHLGGINSITFLENGKRFVTTSDDSSMRFWEYG---- 426 Query: 339 DIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHK 398 + V I D + + + + K +A + +YV+ + Sbjct: 427 ---------TPVPIKFVADIAMHSMPRVALRPN--GKSIACQSLDNCIYVYSAYEKYRQN 475 Query: 399 AKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 K + G ++ + FS D + + + WD Sbjct: 476 KKKVFKGYSCSGYSL-EVGFSPDGRFVFSGDSSGNACFWD 514 Score = 93.8 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 61/390 (15%), Positives = 125/390 (32%), Gaps = 74/390 (18%) Query: 54 DTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVF 113 D N PG ++ + KK +++K H + + ++F S G L+ Sbjct: 238 DVGINLSEEPGEQTC----YIPKKHIFTWK-------GHTKGISCLRFFPIS--GHLLLS 284 Query: 114 ATVGSNRVTLYE-CHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGII 172 ++ N++ ++E H + +R Q + D +F + I Sbjct: 285 GSMD-NQIKIWEVYHDRSLLRTFQGHARPIRDLSF---------SQDGRSFLSTSFDKTI 334 Query: 173 RIINPITMQCIKHYVGHGNAINELKFH--PRDPNLLLSVSKDHALRLWNIQTDTLVAIFG 230 ++ + +C+ + N +KF P PN L+ + D + ++I++ +V + Sbjct: 335 KLWDTELGKCLNCFNS-DRLTNCVKFQVDPDKPNEFLAGTADKRILQFDIRSPDIVQAYD 393 Query: 231 GVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFI 290 H + S + G++ ++ D S++ W +Y + Sbjct: 394 H---HLGGINSITFLENGKRFVTTSDDSSMRFW---------------EYGTPVPIKFVA 435 Query: 291 SQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNV 350 +H +R G I +S +N I + + K Sbjct: 436 DIAMHSMPRV----------ALRPNGKSIACQSLDNCIYVYSAYEKYRQNKK-------- 477 Query: 351 TILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCG 410 F C + + + + G+ G WD L H Sbjct: 478 ---KVFKGYSCSGYSLEVGFSPDGRFVFSGDSSGNACFWD----WKTCKLMAKLPAHS-- 528 Query: 411 AAIRQTSFSRDSSILIAVCD--DASIWRWD 438 ++ +F + +A D SI WD Sbjct: 529 GPVQSMAFHPQETSKVATSSIVDGSIKYWD 558 >5FL8-q nrPDB Length = 515 Score = 168 bits (425), Expect = 4e-42, Method: Composition-based stats. Identities = 63/362 (17%), Positives = 127/362 (35%), Gaps = 57/362 (15%) Query: 124 YECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCI 183 + C QG+ + D +N Y+ N++ + + + + + P+T + Sbjct: 79 FSCTIQGK-KASDPVKTIDITDNLYSSLIKPGYNSTEDQITLLYTPRAVFKVKPVT-RSS 136 Query: 184 KHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSAD 243 GHG+ I F P + +++ + D+ R+W+ T T + ++GH + VL Sbjct: 137 SAIAGHGSTILCSAFAPHTSSRMVTGAGDNTARIWDCDTQTPMHT---LKGHYNWVLCVS 193 Query: 244 YDLLGEKIMSCGMDHSLKLWRINSKRMMNAI-------KESYDYNPNKTNRPFISQ---- 292 + GE I + MD++++LW S + + S + P +P Sbjct: 194 WSPDGEVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLAS 253 Query: 293 -----KIHFPDFSTR------DIHRNYVDCVRWLGD-LILSKSCENAIVCWK---PGKME 337 I D +R H N V CV+W G L+ S S + + W G+ Sbjct: 254 SSKDGTIKIWDTVSRVCQYTMSGHTNSVSCVKWGGQGLLYSGSHDRTVRVWDINSQGRCI 313 Query: 338 DDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMD---------------------FWQKM 376 + + +++++ + + ++M Sbjct: 314 NILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEM 373 Query: 377 LALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWR 436 + + +++W K H K + +FS D +++ D SI Sbjct: 374 MVTASDDYTMFLW--NPLKSTKPIARMTGHQKL---VNHVAFSPDGRYIVSASFDNSIKL 428 Query: 437 WD 438 WD Sbjct: 429 WD 430 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 65/370 (17%), Positives = 135/370 (36%), Gaps = 58/370 (15%) Query: 90 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYT 149 H + F H+ + G N +++C +Q + L+ + + Sbjct: 140 AGHGSTILCSAFAPHT---SSRMVTGAGDNTARIWDCDTQTPMHTLKGHYNWV-----LC 191 Query: 150 CAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKH-YVGHGNAINELKFHPRDPNL--- 205 +W+ D ++A IR+ +P + QC+ GH I L + P Sbjct: 192 VSWSPDG----EVIATGSMDNTIRLWDPKSGQCLGDALRGHSKWITSLSWEPIHLVKPGS 247 Query: 206 ---LLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKL 262 L S SKD +++W+ + + GH + V + G + S D ++++ Sbjct: 248 KPRLASSSKDGTIKIWDTVSRVCQYT---MSGHTNSVSCVKWGGQG-LLYSGSHDRTVRV 303 Query: 263 WRINS-KRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHR----------NYVDC 311 W INS R +N +K + + + + +I D + + NY Sbjct: 304 WDINSQGRCINILKSHAHWVNHLSLSTDYALRIGAFDHTGKKPSTPEEAQKKALENYEKI 363 Query: 312 VRWLGD---LILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRF 368 + G+ ++++ S + + W P K I ++ Q + ++ F Sbjct: 364 CKKNGNSEEMMVTASDDYTMFLWNPLKSTKPIARMT-------------GHQKLVNHVAF 410 Query: 369 SMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAV 428 S D + + + + +WD +T H ++ Q ++S D +L++ Sbjct: 411 SPD--GRYIVSASFDNSIKLWD----GRDGKFISTFRGHVA--SVYQVAWSSDCRLLVSC 462 Query: 429 CDDASIWRWD 438 D ++ WD Sbjct: 463 SKDTTLKVWD 472 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 47/307 (15%), Positives = 97/307 (31%), Gaps = 70/307 (22%) Query: 83 KCVNSLKEDHNQPLFGVQFNWHS--KEGDPLVFATVGSN-RVTLYECHSQGEIRLLQSYV 139 +C+ H++ + + + K G A+ + + +++ S+ + + Sbjct: 219 QCLGDALRGHSKWITSLSWEPIHLVKPGSKPRLASSSKDGTIKIWDTVSRVCQYTMSGHT 278 Query: 140 DADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPIT-MQCIKHYVGHGNAINELKF 198 ++ + W LL +R+ + + +CI H + +N L Sbjct: 279 NSVS-----CVKWGGQG-----LLYSGSHDRTVRVWDINSQGRCINILKSHAHWVNHLSL 328 Query: 199 H----------------PRDPN----------------------LLLSVSKDHALRLWNI 220 P P ++++ S D+ + LWN Sbjct: 329 STDYALRIGAFDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTASDDYTMFLWNP 388 Query: 221 QTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKES--- 277 T + GH+ V + G I+S D+S+KLW + ++ + Sbjct: 389 LKST--KPIARMTGHQKLVNHVAFSPDGRYIVSASFDNSIKLWDGRDGKFISTFRGHVAS 446 Query: 278 -YDYNPNKTNRPFIS----QKIHFPDFSTRD------IHRNYVDCVRWL--GDLILSKSC 324 Y + R +S + D TR H++ V V W G + S Sbjct: 447 VYQVAWSSDCRLLVSCSKDTTLKVWDVRTRKLSVDLPGHKDEVYTVDWSVDGKRVCSGGK 506 Query: 325 ENAIVCW 331 + + W Sbjct: 507 DKMVRLW 513 >3MKQ-A nrPDB Length = 814 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 60/317 (18%), Positives = 112/317 (35%), Gaps = 52/317 (16%) Query: 93 NQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQ-SYVDADADENFYTCA 151 + + G+ F+ +P V T+ S RV ++ +Q E+R +Q + A + Sbjct: 13 SDRVKGIDFHPT----EPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIARKN 68 Query: 152 WTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSK 211 W + V IR+ N T + + + H + I + HP P +LS S Sbjct: 69 W----------IIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKP-YVLSGSD 117 Query: 212 DHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEK-IMSCGMDHSLKLWR------ 264 D ++LWN + + A+ EGH V+ ++ S +D ++K+W Sbjct: 118 DLTVKLWNWENNW--ALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTP 175 Query: 265 ---INSKRMMNAIKESYDYNPNKTNRPFISQ--KIHFPDFSTR------DIHRNYVDCVR 313 + + + Y P+K S I D+ T+ + H + V Sbjct: 176 NFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAV 235 Query: 314 WLGDL--ILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMD 371 + L I+S S + + W + + NV + W + Sbjct: 236 FHPTLPIIISGSEDGTLKIWNSSTYKVE------KTLNVGLERS--------WCIATHPT 281 Query: 372 FWQKMLALGNQVGKLYV 388 + +A G G + Sbjct: 282 GRKNYIASGFDNGFTVL 298 Score = 107 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 48/288 (16%), Positives = 92/288 (31%), Gaps = 53/288 (18%) Query: 155 DSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHA 214 D + + P + G + I N T ++ + KF R N ++ S D Sbjct: 20 DFHPTEPWVLTTLYSGRVEIWNYETQVEVRSIQVTETPVRAGKFIARK-NWIIVGSDDFR 78 Query: 215 LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAI 274 +R++N T V F E H D + S ++S D ++KLW + + Sbjct: 79 IRVFNYNTGEKVVDF---EAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALE-- 133 Query: 275 KESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLG---DLILSKSCENAIVCW 331 T + H ++V CV + S + + W Sbjct: 134 -------------------------QTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVW 168 Query: 332 KPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDL 391 G+ N T+ + + Y+ + + + + + +WD Sbjct: 169 SLGQSTP----------NFTLT---TGQERGVNYVDYYPLPDKPYMITASDDLTIKIWD- 214 Query: 392 EVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDR 439 K+ TL H + F I+I+ +D ++ W+ Sbjct: 215 ---YQTKSCVATLEGHMSN--VSFAVFHPTLPIIISGSEDGTLKIWNS 257 >6G51-g nrPDB Length = 317 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 53/275 (19%), Positives = 97/275 (35%), Gaps = 45/275 (16%) Query: 185 HYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVA--IFGGVEGHRDEVLSA 242 GH + ++ P+ P+++LS S+D + +W + D + GH V Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69 Query: 243 DYDLLGEKIMSCGMDHSLKLWRINSK----RMMNAIKESYDYNPNKTNRPFIS------- 291 G+ +S D +L+LW + + R + K+ + NR +S Sbjct: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129 Query: 292 ---QKIHFPDFSTRD-IHRNYVDCVRWLGD----LILSKSCENAIVCWKPGKMEDDIDKI 343 + ++ +D H +V CVR+ + +I+S + + W Sbjct: 130 KLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW------------ 177 Query: 344 KPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTT 403 + +N + + + S D + A G + G+ +WDL + Sbjct: 178 --NLANCKLKTNHIGHTGYLNTVTVSPD--GSLCASGGKDGQAMLWDLN-------EGKH 226 Query: 404 LTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 L G I FS + L A SI WD Sbjct: 227 LYTLDGGDIINALCFSPNRYWLCAATG-PSIKIWD 260 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 58/362 (16%), Positives = 109/362 (30%), Gaps = 67/362 (18%) Query: 85 VNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSN----RVTLYECHSQGEIRLLQSYVD 140 + + HN + Q + D ++ A+ ++T E + R L+ + Sbjct: 7 LRGTLKGHNG--WVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSH 64 Query: 141 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP 200 +D ++ G +R+ + T + +VGH + + F Sbjct: 65 FVSDVVI---------SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS- 114 Query: 201 RDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL--GEKIMSCGMDH 258 D ++S S+D ++LWN E H + V + I+SCG D Sbjct: 115 SDNRQIVSGSRDKTIKLWNTL-GVCKYTVQD-ESHSEWVSCVRFSPNSSNPIIVSCGWDK 172 Query: 259 SLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDL 318 +K+W + + ++ Y T P G L Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPD--------------------------GSL 206 Query: 319 ILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLA 378 S + + W + L D I + FS + + Sbjct: 207 CASGGKDGQAMLWDLNE--------------GKHLYTLDGGD-IINALCFSPN---RYWL 248 Query: 379 LGNQVGKLYVWDLEVE---DPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIW 435 + +WDLE + D K + + + ++S D L A D + Sbjct: 249 CAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVR 308 Query: 436 RW 437 W Sbjct: 309 VW 310 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 35/286 (12%), Positives = 89/286 (31%), Gaps = 43/286 (15%) Query: 73 WKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEI 132 WK + + ++ H+ + V S +G + + + L++ + Sbjct: 43 WKLTRDETNYGIPQRALRGHSHFVSDV---VISSDGQFALSGSWD-GTLRLWDLTTGTTT 98 Query: 133 RLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHY--VGHG 190 R + F ++ + + I++ N + C H Sbjct: 99 RRFVGHTKDVLSVAF---------SSDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDESHS 148 Query: 191 NAINELKFHPRDPN-LLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGE 249 ++ ++F P N +++S D +++WN+ + GH + + G Sbjct: 149 EWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN---CKLKTNHIGHTGYLNTVTVSPDGS 205 Query: 250 KIMSCGMDHSLKLWRINSKRMMNAI-----KESYDYNPNK----------------TNRP 288 S G D LW +N + + + + ++PN+ + Sbjct: 206 LCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKI 265 Query: 289 FISQKIHFPDFSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWK 332 + + ++ + W G + + +N + W+ Sbjct: 266 IVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311 Score = 71.1 bits (172), Expect = 9e-13, Method: Composition-based stats. Identities = 28/224 (12%), Positives = 73/224 (32%), Gaps = 57/224 (25%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTC 150 H + + V F+ +++ +V + + L+ +Q ++ + Sbjct: 103 GHTKDVLSVAFSSDNRQ---IVSGSRDKT-IKLWN-TLGVCKYTVQDESHSE-----WVS 152 Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS 210 + N+S+P++ G ++++ N + +++GH +N + P D +L S Sbjct: 153 CVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSP-DGSLCASGG 211 Query: 211 KDHALRLWNIQTDTLVAIFGGV------------------EGHRDEVL------------ 240 KD LW++ + G G ++ Sbjct: 212 KDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELK 271 Query: 241 ----------------SADYDLLGEKIMSCGMDHSLKLWRINSK 268 S + G+ + + D+ +++W++ Sbjct: 272 QEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315 Score = 56.1 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 29/141 (20%), Positives = 50/141 (35%), Gaps = 22/141 (15%) Query: 304 IHRNYVDCVR---WLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGR-FDYS 359 H +V + D+ILS S + I+ W K+ E+N I R Sbjct: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMW----------KLTRDETNYGIPQRALRGH 62 Query: 360 QCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFS 419 + + S D + G+ G L +WDL + + +FS Sbjct: 63 SHFVSDVVISSD--GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKD------VLSVAFS 114 Query: 420 RDSSILIAVCDDASIWRWDRL 440 D+ +++ D +I W+ L Sbjct: 115 SDNRQIVSGSRDKTIKLWNTL 135 Score = 39.1 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 31/196 (15%), Positives = 59/196 (30%), Gaps = 66/196 (33%) Query: 78 CKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQS 137 CKY+ + E H++ + V+F+ +S +P++ V L + + +L + Sbjct: 138 CKYTVQ-----DESHSEWVSCVRFSPNSS--NPII---VSCGWDKLVKVWNLANCKLKTN 187 Query: 138 YVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELK 197 ++ T + D L A G G + + + + G G+ IN L Sbjct: 188 HI--GHTGYLNTVTVSPDG----SLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALC 240 Query: 198 FHPR-------------------------------------------------DPNLLLS 208 F P D L + Sbjct: 241 FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300 Query: 209 VSKDHALRLWNIQTDT 224 D+ +R+W + T Sbjct: 301 GYTDNLVRVWQVTIGT 316 >4V6W-Ag nrPDB Length = 318 Score = 163 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 56/284 (19%), Positives = 101/284 (35%), Gaps = 46/284 (16%) Query: 177 PITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV---AIFGGVE 233 T+Q +GH + ++ +P+DP+ ++S S+D L +W + D + Sbjct: 2 SETLQLRGTLIGHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLY 61 Query: 234 GHRDEVLSADYDLLGEKIMSCGMDHSLKLWRIN----SKRMMNAIKESYDYNPNKTNRPF 289 GH + G +S D +L+LW + ++R K+ + NR Sbjct: 62 GHSHFISDVVLSSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFSADNRQI 121 Query: 290 IS----------QKIHFPDFSTR-DIHRNYVDCVRWLGD----LILSKSCENAIVCWKPG 334 +S + F+ + D H ++V CVR+ + +I+S + + W Sbjct: 122 VSGSRDKTIKLWNTLAECKFTIQEDGHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVW--- 178 Query: 335 KMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVE 394 + +N + + + S D + G + K +WDL Sbjct: 179 -----------NLANCKLKNNHHGHNGYLNTVTVSPD--GSLCTSGGKDSKALLWDLN-- 223 Query: 395 DPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 TL H+ I FS + L V SI WD Sbjct: 224 --DGKNLYTLEHNDI---INALCFSPNRYWLC-VAYGPSIKIWD 261 Score = 128 bits (320), Expect = 7e-30, Method: Composition-based stats. Identities = 58/359 (16%), Positives = 114/359 (31%), Gaps = 72/359 (20%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRV--TLYECHSQG---EIRLLQSYVDADADE 145 HN + Q + K+ D ++ A+ + L + L + +D Sbjct: 13 GHNG--WVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQKRLYGHSHFISDV 70 Query: 146 NFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNL 205 ++ +R+ + + + + GH + + F D Sbjct: 71 VL---------SSDGNYALSGSWDQTLRLWDLAAGKTTRRFEGHTKDVLSVAFS-ADNRQ 120 Query: 206 LLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL--GEKIMSCGMDHSLKLW 263 ++S S+D ++LWN + I GH D V + I+SCG D ++K+W Sbjct: 121 IVSGSRDKTIKLWNTLAECKFTIQED--GHTDWVSCVRFSPNHSNPIIVSCGWDRTVKVW 178 Query: 264 RINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL--GDLILS 321 + + ++ N H Y++ V G L S Sbjct: 179 NLANCKLKN----------------------------NHHGHNGYLNTVTVSPDGSLCTS 210 Query: 322 KSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGN 381 ++ + W +D + E I + FS + + +A G Sbjct: 211 GGKDSKALLWD----LNDGKNLYTLE-----------HNDIINALCFSPNRYWLCVAYGP 255 Query: 382 QVGKLYVWDL---EVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 + +WDL + + + + + T ++S D L A D +I W Sbjct: 256 S---IKIWDLACKKTVEELRPEVVSPTSKADQPQCLSLAWSTDGQTLFAGYSDNTIRVW 311 Score = 91.1 bits (224), Expect = 9e-19, Method: Composition-based stats. Identities = 36/244 (14%), Positives = 86/244 (35%), Gaps = 35/244 (14%) Query: 90 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLL-QSYVDADADENFY 148 E H + + V F+ +++ +V + + L+ ++ + + + D + Sbjct: 103 EGHTKDVLSVAFSADNRQ---IVSGSRDKT-IKLWNTLAECKFTIQEDGHTD-------W 151 Query: 149 TCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLS 208 + N S+P++ G +++ N + ++ GH +N + P D +L S Sbjct: 152 VSCVRFSPNHSNPIIVSCGWDRTVKVWNLANCKLKNNHHGHNGYLNTVTVSP-DGSLCTS 210 Query: 209 VSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSK 268 KD LW++ + H D + + + + S+K+W + K Sbjct: 211 GGKDSKALLWDLNDGKNLYTLE----HNDIINALCFSPN-RYWLCVAYGPSIKIWDLACK 265 Query: 269 RMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAI 328 + + ++ +K ++P D G + + +N I Sbjct: 266 KTVEELRPEVVSPTSKADQPQCLSLAWSTD-----------------GQTLFAGYSDNTI 308 Query: 329 VCWK 332 W+ Sbjct: 309 RVWQ 312 Score = 50.3 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 27/140 (19%), Positives = 46/140 (32%), Gaps = 19/140 (13%) Query: 304 IHRNYVDCVRWLG---DLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ 360 H +V + D I+S S + ++ WK + ED R Sbjct: 13 GHNGWVTQIATNPKDPDTIISASRDKTLIVWKLTRDEDTNYGYPQK--------RLYGHS 64 Query: 361 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR 420 I + S D G+ L +WDL + H + +FS Sbjct: 65 HFISDVVLSSD--GNYALSGSWDQTLRLWDLAAGKTTRR----FEGHTKD--VLSVAFSA 116 Query: 421 DSSILIAVCDDASIWRWDRL 440 D+ +++ D +I W+ L Sbjct: 117 DNRQIVSGSRDKTIKLWNTL 136 >2YNP-A nrPDB Length = 604 Score = 163 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 61/317 (19%), Positives = 112/317 (35%), Gaps = 52/317 (16%) Query: 93 NQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQ-SYVDADADENFYTCA 151 + + G+ F+ +P V T+ S RV L+ +Q E+R +Q + A + Sbjct: 13 SDRVKGIDFHPT----EPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARKN 68 Query: 152 WTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSK 211 W + V IR+ N T + + + H + I + HP P +LS S Sbjct: 69 W----------IIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKP-YVLSGSD 117 Query: 212 DHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEK-IMSCGMDHSLKLWR------ 264 D ++LWN + + A+ EGH V+ ++ S +D ++K+W Sbjct: 118 DLTVKLWNWENNW--ALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTP 175 Query: 265 ---INSKRMMNAIKESYDYNPNKTNRPFISQ--KIHFPDFSTR------DIHRNYVDCVR 313 + + + Y P+K S I D+ T+ + H + V Sbjct: 176 NFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAV 235 Query: 314 WLGDL--ILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMD 371 + L I+S S + + W + + NV + W + Sbjct: 236 FHPTLPIIISGSEDGTLKIWNSSTYKVE------KTLNVGLERS--------WCIATHPT 281 Query: 372 FWQKMLALGNQVGKLYV 388 + +A G G + Sbjct: 282 GRKNYIASGFDNGFTVL 298 Score = 104 bits (258), Expect = 1e-22, Method: Composition-based stats. Identities = 47/288 (16%), Positives = 92/288 (31%), Gaps = 53/288 (18%) Query: 155 DSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHA 214 D + + P + G + + N T ++ + KF R N ++ S D Sbjct: 20 DFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARK-NWIIVGSDDFR 78 Query: 215 LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAI 274 +R++N T V F E H D + S ++S D ++KLW + + Sbjct: 79 IRVFNYNTGEKVVDF---EAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALE-- 133 Query: 275 KESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLG---DLILSKSCENAIVCW 331 T + H ++V CV + S + + W Sbjct: 134 -------------------------QTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVW 168 Query: 332 KPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDL 391 G+ N T+ + + Y+ + + + + + +WD Sbjct: 169 SLGQSTP----------NFTLT---TGQERGVNYVDYYPLPDKPYMITASDDLTIKIWD- 214 Query: 392 EVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDR 439 K+ TL H + F I+I+ +D ++ W+ Sbjct: 215 ---YQTKSCVATLEGHMSN--VSFAVFHPTLPIIISGSEDGTLKIWNS 257 >6HQA-B nrPDB Length = 722 Score = 154 bits (389), Expect = 6e-38, Method: Composition-based stats. Identities = 45/230 (19%), Positives = 91/230 (39%), Gaps = 22/230 (9%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRV-TLYECHSQGEIRLLQSYV 139 ++ C+ S K H+ ++ V+F+ FAT ++ L+ C +R+ ++ Sbjct: 484 TYTCLVSYK-GHSSSVWDVKFSPMGH-----YFATASHDQTARLWSCDHIYPLRIFAGHL 537 Query: 140 DADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFH 199 + F + + L S R+ + +C++ ++GH AIN L Sbjct: 538 NDVDCVEF---------HPNSTYLFTGSSDKTARMWDIARGECVRVFMGHSGAINCLAVS 588 Query: 200 PRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGH-RDEVLSADYDLLGEKIMSCGMDH 258 P D L S +D + LW+I T + + GH R + S + G ++S G D+ Sbjct: 589 P-DGRWLASAGEDSVVCLWDISTGRRIK---AMRGHGRSSIYSLAFSREGTVLVSTGADN 644 Query: 259 SLKLWRINSKRMM-NAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRN 307 S+++W + +A E + + + + + H + Sbjct: 645 SVRVWDVKKNTNSPSAQPEPINDVTAQGIQKKTEDLRRRKEIVATNDHMS 694 Score = 136 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 49/296 (16%), Positives = 100/296 (33%), Gaps = 56/296 (18%) Query: 177 PITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGG----- 231 + C+ + N + LKF+ D ++ S +D ++LW+I L ++ Sbjct: 377 SLPSVCMYTFHNTNNDLTCLKFN-DDSTMVASGFQDSFIKLWSIDGSPLRSLLKNDPYNQ 435 Query: 232 -------------VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESY 278 + GH V D+ ++SC D +++LW +++ + + K Sbjct: 436 QNNDGVAVKGSRRLVGHSGAVYGVDFSPDNRYLISCSEDKTVRLWSLDTYTCLVSYKGHS 495 Query: 279 DY--------------NPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGD--LILSK 322 + + H H N VDCV + + + + Sbjct: 496 SSVWDVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNSTYLFTG 555 Query: 323 SCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQ 382 S + W + + F I + S D + LA + Sbjct: 556 SSDKTARMWDIAR--------------GECVRVFMGHSGAINCLAVSPD--GRWLASAGE 599 Query: 383 VGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 + +WD+ + + H ++I +FSR+ ++L++ D S+ WD Sbjct: 600 DSVVCLWDIST----GRRIKAMRGHGR-SSIYSLAFSREGTVLVSTGADNSVRVWD 650 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 45/272 (16%), Positives = 96/272 (35%), Gaps = 46/272 (16%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTC 150 H+ ++GV F+ ++ + + V L+ + + + + + Sbjct: 451 GHSGAVYGVDFSPDNR----YLISCSEDKTVRLWSLDTYTCLVSYKGHS---------SS 497 Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS 210 W + A A R+ + + ++ + GH N ++ ++FHP L + S Sbjct: 498 VWDVKFSPMGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVEFHPNST-YLFTGS 556 Query: 211 KDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRM 270 D R+W+I V +F GH + G + S G D + LW I++ R Sbjct: 557 SDKTARMWDIARGECVRVFM---GHSGAINCLAVSPDGRWLASAGEDSVVCLWDISTGRR 613 Query: 271 MNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL--GDLILSKSCENAI 328 + A+ R R+ + + + G +++S +N++ Sbjct: 614 IKAM---------------------------RGHGRSSIYSLAFSREGTVLVSTGADNSV 646 Query: 329 VCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ 360 W K + ++VT G ++ Sbjct: 647 RVWDVKKNTNSPSAQPEPINDVTAQGIQKKTE 678 Score = 91.5 bits (225), Expect = 6e-19, Method: Composition-based stats. Identities = 35/229 (15%), Positives = 65/229 (28%), Gaps = 31/229 (13%) Query: 215 LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAI 274 ++L Q +++ ++ + S D +KLW I+ + + + Sbjct: 369 IKLSAAQASLPSVCMYTFHNTNNDLTCLKFNDDSTMVASGFQDSFIKLWSIDGSPLRSLL 428 Query: 275 KESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGD--LILSKSCENAIVCWK 332 K N + H V V + D ++S S + + W Sbjct: 429 KNDPYNQQNNDGVAVKGSRRLV-------GHSGAVYGVDFSPDNRYLISCSEDKTVRLW- 480 Query: 333 PGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLE 392 S T L + +W ++FS A + +W + Sbjct: 481 -------------SLDTYTCLVSYKGHSSSVWDVKFSP--MGHYFATASHDQTARLWSCD 525 Query: 393 VEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 441 P + L C F +S+ L D + WD R Sbjct: 526 HIYPLRIFAGHLNDVDC------VEFHPNSTYLFTGSSDKTARMWDIAR 568 >3DM0-A nrPDB Length = 694 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 51/277 (18%), Positives = 99/277 (35%), Gaps = 47/277 (16%) Query: 185 HYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGG--VEGHRDEVLSA 242 H + + + + ++++S S+D ++ LW + D + GH V Sbjct: 377 TMRAHTDMVTAIATPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHSHFVEDV 436 Query: 243 DYDLLGEKIMSCGMDHSLKLWR----INSKRMMNAIKESYDYNPNKTNRPFIS------- 291 G+ +S D L+LW ++++R + K+ + NR +S Sbjct: 437 VLSSDGQFALSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFSLDNRQIVSASRDRTI 496 Query: 292 ---QKIHFPDFSTR---DIHRNYVDCVRWLGD----LILSKSCENAIVCWKPGKMEDDID 341 + ++ + HR++V CVR+ + I+S S + + W Sbjct: 497 KLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKVW---------- 546 Query: 342 KIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKC 401 + SN + + + S D + A G + G + +WDL A+ Sbjct: 547 ----NLSNCKLRSTLAGHTGYVSTVAVSPD--GSLCASGGKDGVVLLWDL-------AEG 593 Query: 402 TTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 L + + I FS + L A + I WD Sbjct: 594 KKLYSLEANSVIHALCFSPNRYWLCAA-TEHGIKIWD 629 Score = 148 bits (373), Expect = 4e-36, Method: Composition-based stats. Identities = 58/370 (15%), Positives = 115/370 (31%), Gaps = 71/370 (19%) Query: 85 VNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADAD 144 + H + + + ++ + + L++ + + Sbjct: 374 LKGTMRAHTDMVTAIA---TPIDNADIIVSASRDKSIILWKLTKDDKAYGVAQRRLTGHS 430 Query: 145 ENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPN 204 + D + G +R+ + + +VGH + + F D Sbjct: 431 HFVEDVVLSSDGQFA----LSGSWDGELRLWDLAAGVSTRRFVGHTKDVLSVAFS-LDNR 485 Query: 205 LLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL--GEKIMSCGMDHSLKL 262 ++S S+D ++LWN + I G EGHRD V + I+S D ++K+ Sbjct: 486 QIVSASRDRTIKLWNTLGECKYTISEGGEGHRDWVSCVRFSPNTLQPTIVSASWDKTVKV 545 Query: 263 WRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL--GDLIL 320 W +++ ++ + + H YV V G L Sbjct: 546 WNLSNCKLRSTLA----------------------------GHTGYVSTVAVSPDGSLCA 577 Query: 321 SKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALG 380 S + ++ W + K+ E+N I + FS + + Sbjct: 578 SGGKDGVVLLWD----LAEGKKLYSLEAN-----------SVIHALCFSPN---RYWLCA 619 Query: 381 NQVGKLYVWDLE-------VEDPHKAKCTTLTHHKCGAAIRQTSF------SRDSSILIA 427 + +WDLE ++ KA+ + A R+ + S D S L + Sbjct: 620 ATEHGIKIWDLESKSIVEDLKVDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLFS 679 Query: 428 VCDDASIWRW 437 D I W Sbjct: 680 GYTDGVIRVW 689 Score = 78.1 bits (190), Expect = 8e-15, Method: Composition-based stats. Identities = 30/232 (12%), Positives = 70/232 (30%), Gaps = 67/232 (28%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNR-VTLYECHSQGEIRLLQSYVDADADENFYT 149 H + + V F+ +++ + +R + L+ + GE + S + + Sbjct: 470 GHTKDVLSVAFSLDNRQ-----IVSASRDRTIKLWN--TLGECKYTISEGGEGHRD--WV 520 Query: 150 CAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSV 209 + NT P + A +++ N + GH ++ + P D +L S Sbjct: 521 SCVRFSPNTLQPTIVSASWDKTVKVWNLSNCKLRSTLAGHTGYVSTVAVSP-DGSLCASG 579 Query: 210 SKDHAL----------------------------------------RLWNIQTDTLVAIF 229 KD + ++W++++ ++V Sbjct: 580 GKDGVVLLWDLAEGKKLYSLEANSVIHALCFSPNRYWLCAATEHGIKIWDLESKSIVEDL 639 Query: 230 --------------GGVEGHRDEVLS--ADYDLLGEKIMSCGMDHSLKLWRI 265 G R + ++ G + S D +++W I Sbjct: 640 KVDLKAEAEKADNSGPAATKRKVIYCTSLNWSADGSTLFSGYTDGVIRVWGI 691 Score = 51.5 bits (121), Expect = 8e-07, Method: Composition-based stats. Identities = 27/143 (18%), Positives = 53/143 (37%), Gaps = 20/143 (13%) Query: 301 TRDIHRNYVDCVRW---LGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFD 357 T H + V + D+I+S S + +I+ W K+ D ++ +T Sbjct: 377 TMRAHTDMVTAIATPIDNADIIVSASRDKSIILW---KLTKDDKAYGVAQRRLT------ 427 Query: 358 YSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTS 417 + + S D + G+ G+L +WDL + + + Sbjct: 428 GHSHFVEDVVLSSD--GQFALSGSWDGELRLWDLAAGVSTRRFVGHTKD------VLSVA 479 Query: 418 FSRDSSILIAVCDDASIWRWDRL 440 FS D+ +++ D +I W+ L Sbjct: 480 FSLDNRQIVSASRDRTIKLWNTL 502 >6QDV-o nrPDB Length = 513 Score = 148 bits (373), Expect = 4e-36, Method: Composition-based stats. Identities = 49/280 (17%), Positives = 102/280 (36%), Gaps = 36/280 (12%) Query: 177 PITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHR 236 + + I + GH ++ ++ P +LLLS S D ++LW + + GH Sbjct: 209 YLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGER--RCLRTFIGHS 266 Query: 237 DEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMN-----AIKESYDYNPNKT------ 285 V ++ G + +S D LKLW + + ++ + +NP++ Sbjct: 267 KAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFV 326 Query: 286 ----NRPFISQKIHFPD-FSTRDIHRNYVDCVRWLGD--LILSKSCENAIVCWKPGKMED 338 ++ + I + D H V+ + ++ + +S S + ++ W+ Sbjct: 327 AGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWE------ 380 Query: 339 DIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHK 398 + V + S + + S + K LA + ++ ++ + Sbjct: 381 -------WDIPVDFKYIAEPSMHSMPAVTLSPN--GKWLACQSMDNQILIFGAQNRFRLN 431 Query: 399 AKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 K H G A Q FS D S +I+ + + WD Sbjct: 432 KKKIFKGHMVAGYA-CQVDFSPDMSYVISGDGNGKLNIWD 470 Score = 88.1 bits (216), Expect = 6e-18, Method: Composition-based stats. Identities = 41/312 (13%), Positives = 84/312 (26%), Gaps = 59/312 (18%) Query: 83 KCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDAD 142 +C+ + H++ + + FN + + + L++ + I Sbjct: 257 RCLRTF-IGHSKAVRDICFNTAGTQ----FLSAAYDRYLKLWDTETGQCISRF------T 305 Query: 143 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRD 202 + Y + D + L S I + + + ++ Y H A+N + F + Sbjct: 306 NRKVPYCVKFNPDED-KQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDEN 364 Query: 203 PNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKL 262 +S S D +LR+W H + G+ + MD+ + + Sbjct: 365 RRF-VSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILI 421 Query: 263 WRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHR--NYVDCVRWLGD--L 318 + H Y V + D Sbjct: 422 -------------------------FGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSY 456 Query: 319 ILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLA 378 ++S + W D K RF + K++ Sbjct: 457 VISGDGNGKLNIW-------DWKTTKLYS-------RFKAHDKVCIGAVWHPHETSKVIT 502 Query: 379 LGNQVGKLYVWD 390 G G + +WD Sbjct: 503 CG-WDGLIKLWD 513 >5YZG-W nrPDB Length = 579 Score = 148 bits (372), Expect = 5e-36, Method: Composition-based stats. Identities = 49/280 (17%), Positives = 102/280 (36%), Gaps = 36/280 (12%) Query: 177 PITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHR 236 + + I + GH ++ ++ P +LLLS S D ++LW + + GH Sbjct: 275 YLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGER--RCLRTFIGHS 332 Query: 237 DEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMN-----AIKESYDYNPNKT------ 285 V ++ G + +S D LKLW + + ++ + +NP++ Sbjct: 333 KAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFV 392 Query: 286 ----NRPFISQKIHFPD-FSTRDIHRNYVDCVRWLGD--LILSKSCENAIVCWKPGKMED 338 ++ + I + D H V+ + ++ + +S S + ++ W+ Sbjct: 393 AGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWE------ 446 Query: 339 DIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHK 398 + V + S + + S + K LA + ++ ++ + Sbjct: 447 -------WDIPVDFKYIAEPSMHSMPAVTLSPN--GKWLACQSMDNQILIFGAQNRFRLN 497 Query: 399 AKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 K H G A Q FS D S +I+ + + WD Sbjct: 498 KKKIFKGHMVAGYA-CQVDFSPDMSYVISGDGNGKLNIWD 536 Score = 88.1 bits (216), Expect = 8e-18, Method: Composition-based stats. Identities = 41/312 (13%), Positives = 84/312 (26%), Gaps = 59/312 (18%) Query: 83 KCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDAD 142 +C+ + H++ + + FN + + + L++ + I Sbjct: 323 RCLRTF-IGHSKAVRDICFNTAGTQ----FLSAAYDRYLKLWDTETGQCISRF------T 371 Query: 143 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRD 202 + Y + D + L S I + + + ++ Y H A+N + F + Sbjct: 372 NRKVPYCVKFNPDED-KQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDEN 430 Query: 203 PNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKL 262 +S S D +LR+W H + G+ + MD+ + + Sbjct: 431 RRF-VSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILI 487 Query: 263 WRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHR--NYVDCVRWLGD--L 318 + H Y V + D Sbjct: 488 -------------------------FGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSY 522 Query: 319 ILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLA 378 ++S + W D K RF + K++ Sbjct: 523 VISGDGNGKLNIW-------DWKTTKLYS-------RFKAHDKVCIGAVWHPHETSKVIT 568 Query: 379 LGNQVGKLYVWD 390 G G + +WD Sbjct: 569 CG-WDGLIKLWD 579 >5GAN-H nrPDB Length = 465 Score = 147 bits (371), Expect = 9e-36, Method: Composition-based stats. Identities = 41/181 (22%), Positives = 85/181 (46%), Gaps = 21/181 (11%) Query: 88 LKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVT-LYECHSQGEIRLLQSYVDADADEN 146 L+E H++ +F + F + D + + G + ++ L++ S ++ L + + Sbjct: 302 LQEGHDKGVFSLSF-----QCDGSLVCSGGMDSLSMLWDIRSGSKVMTLAGH-----SKP 351 Query: 147 FYTCAWTYDSNTSHPLLAVAGSRGIIRIIN--PITMQCIKHYVGHGNAINELKFHPRDP- 203 YT AW+ + +A G GII + + + + H N + +++F D Sbjct: 352 IYTVAWSPNGYQ----VATGGGDGIINVWDIRKRDEGQLNQILAHRNIVTQVRFSKEDGG 407 Query: 204 NLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLW 263 L+S D+ + +++ +DT + + G + GH D+++S D ++S G D S+KLW Sbjct: 408 KKLVSCGYDNLINVYS--SDTWLKM-GSLAGHTDKIISLDISNNSHFLVSGGWDRSIKLW 464 Query: 264 R 264 Sbjct: 465 N 465 Score = 105 bits (262), Expect = 4e-23, Method: Composition-based stats. Identities = 60/293 (20%), Positives = 95/293 (32%), Gaps = 59/293 (20%) Query: 152 WTYDSNTSHPLLAVAGSRGIIRIINPITMQ----CIKHYVGHGNAINELKFHPRDPNLLL 207 W DSN + G+I+ + + VGH I+++K+HP + Sbjct: 226 WHPDSNN---QMISCAEDGLIKNFQYSNEEGGLRLLGDLVGHERRISDVKYHPS-GKFIG 281 Query: 208 SVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 267 S S D RLW+ T + + EGH V S + G + S GMD LW I S Sbjct: 282 SASHDMTWRLWDASTHQELLL---QEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWDIRS 338 Query: 268 KRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDL--ILSKSCE 325 + + H + V W + + + + Sbjct: 339 GSKVMTLA----------------------------GHSKPIYTVAWSPNGYQVATGGGD 370 Query: 326 NAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGK 385 I W DI K + N + + + +RFS + K L Sbjct: 371 GIINVW-------DIRKRDEGQLN-----QILAHRNIVTQVRFSKEDGGKKLVSCGYDNL 418 Query: 386 LYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 + V+ K +L H I S +S L++ D SI W+ Sbjct: 419 INVYS----SDTWLKMGSLAGHT--DKIISLDISNNSHFLVSGGWDRSIKLWN 465 Score = 95.8 bits (236), Expect = 3e-20, Method: Composition-based stats. Identities = 47/284 (16%), Positives = 103/284 (36%), Gaps = 54/284 (19%) Query: 157 NTSHPLLAVAGSRGIIRIINPITMQCI-KHYVGHGNAINELKFHPRDPNLLLSVSKDHAL 215 +T ++A G ++++N T+Q + + H I + +HP N ++S ++D + Sbjct: 184 STDDMVVATGSWAGDLQVLNSQTLQPLTQKLDSHVGKIGAIDWHPDSNNQMISCAEDGLI 243 Query: 216 RLWNIQTDT-LVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAI 274 + + + + + G + GH + Y G+ I S D + +LW ++ + + Sbjct: 244 KNFQYSNEEGGLRLLGDLVGHERRISDVKYHPSGKFIGSASHDMTWRLWDASTHQEL--- 300 Query: 275 KESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWK 332 ++ H V + + G L+ S ++ + W Sbjct: 301 -------------------------LLQEGHDKGVFSLSFQCDGSLVCSGGMDSLSMLWD 335 Query: 333 PGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLE 392 + + + I+ + +S + +Q +A G G + VWD+ Sbjct: 336 --------------IRSGSKVMTLAGHSKPIYTVAWSPNGYQ--VATGGGDGIINVWDIR 379 Query: 393 VEDPHKAKCTTLTHHKCGAAIRQTSFSRD--SSILIAVCDDASI 434 D + L H + Q FS++ L++ D I Sbjct: 380 KRDEGQLNQI-LAHRNI---VTQVRFSKEDGGKKLVSCGYDNLI 419 >5NZU-C nrPDB Length = 905 Score = 147 bits (369), Expect = 1e-35, Method: Composition-based stats. Identities = 46/314 (14%), Positives = 105/314 (33%), Gaps = 63/314 (20%) Query: 107 EGDPLVFATVGSNRVTLYECHSQGEIRLLQS-YVDADADENFYTCAWTYDSNTSHPLLAV 165 +P + A++ + V ++ +Q ++ + + A + W + Sbjct: 25 PTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNW----------VVT 74 Query: 166 AGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTL 225 IR+ N T++ + + H + I + HP P +L+ S D ++LW+ Sbjct: 75 GADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQP-FILTSSDDMLIKLWDWDKKW- 132 Query: 226 VAIFGGVEGHRDEVLSADYDL-LGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNK 284 + EGH V+ + + S +D ++K+W++ S +PN Sbjct: 133 -SCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGS------------SSPNF 179 Query: 285 TNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGD----LILSKSCENAIVCWKPGKMEDDI 340 T H V+C+ + ++S + + + W Sbjct: 180 TLE----------------GHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDY------- 216 Query: 341 DKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAK 400 N T + + ++ F + ++ G++ G + +W Sbjct: 217 -------QNKTCVQTLEGHAQNVSCASFHPEL--PIIITGSEDGTVRIWHSSTYRLESTL 267 Query: 401 CTTLTHHKCGAAIR 414 + C A++R Sbjct: 268 NYGMERVWCVASLR 281 Score = 108 bits (269), Expect = 5e-24, Method: Composition-based stats. Identities = 34/227 (14%), Positives = 78/227 (34%), Gaps = 20/227 (8%) Query: 54 DTPTNTPNAPGRKSW---GKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDP 110 D P RK+W G + + Y+ + E H+ + + + P Sbjct: 57 DLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPT----QP 112 Query: 111 LVFATVGSNRVTLYE-CHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSR 169 + + + L++ ++ + + + A A Sbjct: 113 FILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPK--------DNNQFASASLD 164 Query: 170 GIIRIINPITMQCIKHYVGHGNAINEL-KFHPRDPNLLLSVSKDHALRLWNIQTDTLVAI 228 I++ + GH +N + + D L+S + D +++W+ Q T V Sbjct: 165 RTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQT 224 Query: 229 FGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK 275 +EGH V A + I++ D ++++W ++ R+ + + Sbjct: 225 ---LEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLN 268 Score = 108 bits (268), Expect = 7e-24, Method: Composition-based stats. Identities = 49/288 (17%), Positives = 95/288 (32%), Gaps = 54/288 (18%) Query: 153 TYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKD 212 + D + + P + + G + + N T +K + + KF R N +++ + D Sbjct: 20 SVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARK-NWVVTGADD 78 Query: 213 HALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMN 272 +R++N T V +F E H D + I++ D +KLW + K Sbjct: 79 MQIRVFNYNTLERVHMF---EAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKK---- 131 Query: 273 AIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLG---DLILSKSCENAIV 329 + + H +YV + + S S + I Sbjct: 132 -----------------------WSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIK 168 Query: 330 CWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVW 389 W+ G N T+ + + + + + + L G + +W Sbjct: 169 VWQLGSSSP----------NFTL----EGHEKGVNCIDYYSGGDKPYLISGADDRLVKIW 214 Query: 390 DLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 D +K TL H + SF + I+I +D ++ W Sbjct: 215 D----YQNKTCVQTLEGHAQN--VSCASFHPELPIIITGSEDGTVRIW 256 Score = 71.9 bits (174), Expect = 5e-13, Method: Composition-based stats. Identities = 31/219 (14%), Positives = 65/219 (29%), Gaps = 34/219 (15%) Query: 236 RDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAI--------------KESYDYN 281 D V S D +++ + S+ +W ++ ++ ++++ Sbjct: 15 SDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVT 74 Query: 282 PNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGD--LILSKSCENAIVCWKPGKMEDD 339 + + + H +Y+ C+ IL+ S + I W Sbjct: 75 GADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD------- 127 Query: 340 IDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKA 399 + + F+ + + + A + + VW L P+ Sbjct: 128 ------WDKKWSCSQVFEGHTHYVMQIVINP-KDNNQFASASLDRTIKVWQLGSSSPN-- 178 Query: 400 KCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 TL H+ G D LI+ DD + WD Sbjct: 179 --FTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWD 215 >6QX9-4B nrPDB Length = 522 Score = 141 bits (356), Expect = 4e-34, Method: Composition-based stats. Identities = 34/176 (19%), Positives = 71/176 (40%), Gaps = 18/176 (10%) Query: 89 KEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRV-TLYECHSQGEIRLLQSYVDADADENF 147 +E H+ ++ + F+ D + T G + +++ + I L+ ++ NF Sbjct: 361 QEGHSMGVYDIAFHQ-----DGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINF 415 Query: 148 YTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLL 207 + + +A ++ + +C+ H N + +KF P N LL Sbjct: 416 -----SPNGYH----IATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLL 466 Query: 208 SVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLW 263 + + D+ ++W T + + GH +V+ D G+ I +C D + KLW Sbjct: 467 TGAYDNTAKIW---THPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519 Score = 131 bits (328), Expect = 8e-31, Method: Composition-based stats. Identities = 51/324 (15%), Positives = 107/324 (33%), Gaps = 69/324 (21%) Query: 73 WKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSK----EGDPLVFATVGSNRVTLYECHS 128 W C +++L+ HN + + F+ S D + + V L+ S Sbjct: 258 WSVPDCNL----LHTLR-GHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDS 312 Query: 129 QGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVG 188 + ++ + W S L R+ + + I H G Sbjct: 313 DEPVADIEGHT-----VRVARVMWHP----SGRFLGTTCYDRSWRLWDLEAQEEILHQEG 363 Query: 189 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLG 248 H + ++ FH +D +L + D R+W+++T + +EGH E+ ++ G Sbjct: 364 HSMGVYDIAFH-QDGSLAGTGGLDAFGRVWDLRTGRCI---MFLEGHLKEIYGINFSPNG 419 Query: 249 EKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNY 308 I + D++ K+W + +R + I H+N Sbjct: 420 YHIATGSGDNTCKVWDLRQRRCVYTIP----------------------------AHQNL 451 Query: 309 VDCVRW---LGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWY 365 V V++ G+ +L+ + +N W +K + + Sbjct: 452 VTGVKFEPIHGNFLLTGAYDNTAKIW----THPGWSPLK----------TLAGHEGKVMG 497 Query: 366 MRFSMDFWQKMLALGNQVGKLYVW 389 + S D +++A + +W Sbjct: 498 LDISSD--GQLIATCSYDRTFKLW 519 Score = 107 bits (267), Expect = 8e-24, Method: Composition-based stats. Identities = 52/320 (16%), Positives = 104/320 (32%), Gaps = 51/320 (15%) Query: 141 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP 200 D C ++ +S +LA A G+ ++ + + GH + + FHP Sbjct: 228 IGDDRPISYCHFSPNS----KMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHP 283 Query: 201 RDPNL-------LLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMS 253 + L S + D +++LW++ +D VA +EGH V + G + + Sbjct: 284 KSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVA---DIEGHTVRVARVMWHPSGRFLGT 340 Query: 254 CGMDHSLKLWRINSKRM----MNAIKESYDYNPNKTNRPFISQKI----HFPDFST---- 301 D S +LW + ++ YD ++ + + D T Sbjct: 341 TCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCI 400 Query: 302 --RDIHRNYVDCVRWLGDL--ILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFD 357 + H + + + + I + S +N W D+ + + + Sbjct: 401 MFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVW-------DLRQRR-------CVYTIP 446 Query: 358 YSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTS 417 Q + ++F L G +W P + TL H+ + Sbjct: 447 AHQNLVTGVKFEPIH-GNFLLTGAYDNTAKIW----THPGWSPLKTLAGHE--GKVMGLD 499 Query: 418 FSRDSSILIAVCDDASIWRW 437 S D ++ D + W Sbjct: 500 ISSDGQLIATCSYDRTFKLW 519 Score = 59.2 bits (141), Expect = 3e-09, Method: Composition-based stats. Identities = 30/234 (12%), Positives = 60/234 (25%), Gaps = 46/234 (19%) Query: 229 FGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRP 288 F G + + + + + KLW + +++ ++ P Sbjct: 224 FCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHP 283 Query: 289 FISQKIHFPDFSTR----------------------DIHRNYVDCVRWLGD-LILSKSC- 324 + + D + + H V V W L +C Sbjct: 284 KSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCY 343 Query: 325 ENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVG 384 + + W E+ + + + ++ + F D + G Sbjct: 344 DRSWRLWDLEAQEEILHQ--------------EGHSMGVYDIAFHQD--GSLAGTGGLDA 387 Query: 385 KLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 VWDL + H K I FS + + D + WD Sbjct: 388 FGRVWDLRTG---RCIMFLEGHLKEIYGIN---FSPNGYHIATGSGDNTCKVWD 435 >5K1B-B nrPDB Length = 677 Score = 134 bits (337), Expect = 7e-32, Method: Composition-based stats. Identities = 58/279 (20%), Positives = 104/279 (37%), Gaps = 48/279 (17%) Query: 190 GNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGE 249 N +N L+ P L + +D +R+W++ +E H D V G+ Sbjct: 30 RNGVNALQLDPALNR-LFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGK 88 Query: 250 KIMSCGMDHSLKLWRINSKRMMNAIKESYDY--------NPNKTNRPFISQKIHFPDFST 301 ++S D ++K+W + M+ ++ DY + + ++I D +T Sbjct: 89 TLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT 148 Query: 302 RDIHRN-----------------YVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIK 344 Y + LG +I+S S E + W P + + K+K Sbjct: 149 LTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDP-RTCAKLMKLK 207 Query: 345 PSESNVT-ILGRFDYSQCDIWYMRFSMDFWQKMLALGNQ-------VGKLYVWDLEVEDP 396 NV +L D +QC + S D ++ +LG Q V VW L+V D Sbjct: 208 GHTDNVKALLLNRDGTQC----LSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVND- 262 Query: 397 HKAKCTTLTHHKCGAAIRQTSFS--RDSSILIAVCDDAS 433 TH G R+ + R+ I + +C++ + Sbjct: 263 ------AFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKA 295 Score = 84.6 bits (207), Expect = 9e-17, Method: Composition-based stats. Identities = 36/244 (14%), Positives = 88/244 (36%), Gaps = 13/244 (5%) Query: 84 CVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR-VTLYECHSQGEIRLLQSYVDAD 142 C+++L+ H + + + D + A+ G +R + L++ ++ + + V Sbjct: 109 CMSTLRT-HKDYVKALAY-----AKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTS 162 Query: 143 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRD 202 + ++ N ++ + ++R+ +P T + GH + + L + RD Sbjct: 163 SLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLN-RD 221 Query: 203 PNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKL 262 LS S D +RLW++ +A + H + V + + + S G D + Sbjct: 222 GTQCLSGSSDGTIRLWSLGQQRCIATYRV---HDEGVWALQVNDAFTHVYSGGRDRKIYC 278 Query: 263 WRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSK 322 + + + I E +T+ + ++ + + S Sbjct: 279 TDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWT--LKGIHNFRASG 336 Query: 323 SCEN 326 +N Sbjct: 337 DYDN 340 >3JB9-L nrPDB Length = 340 Score = 134 bits (337), Expect = 7e-32, Method: Composition-based stats. Identities = 51/352 (14%), Positives = 122/352 (34%), Gaps = 69/352 (19%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNR-VTLY----ECHSQGEIRLLQSYVDADADE 145 H + +F+ FA+ G +R + L+ + + G + + + Sbjct: 48 GHTAEVLVARFDP-----SGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQ-- 100 Query: 146 NFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNL 205 W+ DS ++ + S + + ++ Q I+ + GH +N L L Sbjct: 101 ------WSRDS----RVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSEL 150 Query: 206 LLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI 265 L SVS D +++W+ ++ + + + + G ++ G+D ++K+W + Sbjct: 151 LTSVSDDCTMKVWDSRSKDCIKTIEE----KYPLTAVAIAQQGTQVFIGGIDGAIKIWDL 206 Query: 266 NSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCE 325 + + +K D + + G +LS S + Sbjct: 207 RNNHCSHVLKGHKDIITS--------------------------LAISKDGSSLLSNSMD 240 Query: 326 NAIVCWKPGKMEDDIDKIKPSESNVTIL-GRFDYSQCDIWYMRFSMDFWQKMLALGNQVG 384 N + + D+ ++ + I G + ++ + +S + + + G+ Sbjct: 241 NTVRIF-------DVKPFASAQRQLQIFEGAIHGQEHNLLGVAWSRNS--RFVGAGSSDK 291 Query: 385 KLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWR 436 +YVW L H+ ++ F I+++ D +I+ Sbjct: 292 NVYVWSAT-----GDLRYVLPGHE--GSVNHVDFHPHQDIILSCSSDRTIFL 336 Score = 85.8 bits (210), Expect = 4e-17, Method: Composition-based stats. Identities = 47/287 (16%), Positives = 88/287 (30%), Gaps = 51/287 (17%) Query: 157 NTSHPLLAVAGSRGIIRIINPI-TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHAL 215 + S A G I + N ++ G AI +L++ RD ++ S D L Sbjct: 59 DPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKGAITDLQWS-RDSRVVYCSSSDTHL 117 Query: 216 RLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLG-EKIMSCGMDHSLKLWRINSKRMMNAI 274 W+ + + +GH V + D +G E + S D ++K+W SK + I Sbjct: 118 MSWDAVSGQKIRK---HKGHAGVVNALDVLKVGSELLTSVSDDCTMKVWDSRSKDCIKTI 174 Query: 275 KESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPG 334 +E Y + G + + AI W Sbjct: 175 EEKYPLT---------------------------AVAIAQQGTQVFIGGIDGAIKIWD-- 205 Query: 335 KMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVE 394 N + I + S D L + + ++D++ Sbjct: 206 ------------LRNNHCSHVLKGHKDIITSLAISKD--GSSLLSNSMDNTVRIFDVKPF 251 Query: 395 DPHKAKCTTLTHHKCGAAIR--QTSFSRDSSILIAVCDDASIWRWDR 439 + + G ++SR+S + A D +++ W Sbjct: 252 ASAQRQLQIFEGAIHGQEHNLLGVAWSRNSRFVGAGSSDKNVYVWSA 298 Score = 71.5 bits (173), Expect = 6e-13, Method: Composition-based stats. Identities = 44/237 (18%), Positives = 73/237 (30%), Gaps = 43/237 (18%) Query: 221 QTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS--------KRMMN 272 +T L + GH EVL A +D G S GMD + LW + Sbjct: 35 RTSDLNVPNLQMFGHTAEVLVARFDPSGSYFASGGMDRQILLWNVFGDVKNYGVLNGCKG 94 Query: 273 AIKE-------SYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDC---VRWLGDLILSK 322 AI + Y + + H V+ ++ +L+ S Sbjct: 95 AITDLQWSRDSRVVYCSSSDTHLMSWDAVSGQKIRKHKGHAGVVNALDVLKVGSELLTSV 154 Query: 323 SCENAIVCWKP-GKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGN 381 S + + W K + K + V I + + +G Sbjct: 155 SDDCTMKVWDSRSKDCIKTIEEKYPLTAVAIAQQ------------------GTQVFIGG 196 Query: 382 QVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 G + +WDL L HK I + S+D S L++ D ++ +D Sbjct: 197 IDGAIKIWDLRNNHCSHV----LKGHK--DIITSLAISKDGSSLLSNSMDNTVRIFD 247 Score = 46.8 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 21/115 (18%), Positives = 40/115 (34%), Gaps = 8/115 (6%) Query: 326 NAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGK 385 I + + + S+ NV L F ++ RF A G + Sbjct: 17 KRIRIQDSSLITEGSVLQRTSDLNVPNLQMF-GHTAEVLVARFDPS--GSYFASGGMDRQ 73 Query: 386 LYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL 440 + +W++ + + + C AI +SRDS ++ D + WD + Sbjct: 74 ILLWNVFGDVKNYGVL-----NGCKGAITDLQWSRDSRVVYCSSSDTHLMSWDAV 123 >6ID0-T nrPDB Length = 514 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 44/309 (14%), Positives = 102/309 (33%), Gaps = 35/309 (11%) Query: 106 KEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAV 165 + G+ + +++ S L ++ +T P L Sbjct: 213 EPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV---------STRSPYLFS 263 Query: 166 AGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTL 225 G ++ + + I+HY GH +A+ L HP ++L++ S+D R+W+++T Sbjct: 264 CGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTI-DVLVTCSRDSTARIWDVRTKAS 322 Query: 226 VAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAI----------- 274 V + GH + V + +I++ D +++LW + + + + Sbjct: 323 VHT---LSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVV 379 Query: 275 --KESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCEN-AIVCW 331 Y + + + H ++ + D +L +N + W Sbjct: 380 LHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLW 439 Query: 332 KPGKMEDDIDKIKPSES-NVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWD 390 D + + + S+ I+ F + + A ++ K+Y D Sbjct: 440 -------DWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYRED 492 Query: 391 LEVEDPHKA 399 + Sbjct: 493 DTATEETHP 501 Score = 109 bits (272), Expect = 3e-24, Method: Composition-based stats. Identities = 43/299 (14%), Positives = 88/299 (29%), Gaps = 44/299 (14%) Query: 156 SNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHAL 215 NT + L + + + + + GH + + P ++ S D + Sbjct: 170 GNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEP-GNQWFVTGSADRTI 228 Query: 216 RLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK 275 ++W++ + + + GH V + SCG D +K W + +++ Sbjct: 229 KIWDLASG---KLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYH 285 Query: 276 ESYDYNPNKTNRPFI--------SQKIHFPDFSTR------DIHRNYVDCVRWLGD--LI 319 P I D T+ H N V VR I Sbjct: 286 GHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQI 345 Query: 320 LSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLAL 379 ++ S + I W + + + + A Sbjct: 346 ITGSHDTTIRLWD--------------LVAGKTRVTLTNHKKSVRAVVLHPRHY--TFAS 389 Query: 380 GNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 G+ + W + P + L+ H I + + D +L++ D+ ++ WD Sbjct: 390 GSPDN-IKQW----KFPDGSFIQNLSGHNA--IINTLTVNSDG-VLVSGADNGTMHLWD 440 >6HHQ-h nrPDB Length = 319 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 48/281 (17%), Positives = 89/281 (31%), Gaps = 69/281 (24%) Query: 162 LLAVAGSRGIIRIINPIT-----MQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALR 216 LL A + ++ + GH + + + D LS S D LR Sbjct: 32 LLLSASRDKTLISWKLTGDDQKFGVPVRSFKGHSHIVQDCTLT-ADGAYALSASWDKTLR 90 Query: 217 LWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE 276 LW++ T F GH+ +V+S D D I+S D ++K+W I + + + Sbjct: 91 LWDVATGETYQRFV---GHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKGQCLATLL-- 145 Query: 277 SYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGD--------LILSKSCENAI 328 H ++V VR + + I+S + + Sbjct: 146 ---------------------------GHNDWVSQVRVVPNEKADDDSVTIISAGNDKMV 178 Query: 329 VCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYV 388 W + + I F +I + S D ++A + G++ + Sbjct: 179 KAW--------------NLNQFQIEADFIGHNSNINTLTASPD--GTLIASAGKDGEIML 222 Query: 389 WDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVC 429 W+L + + +FS + L A Sbjct: 223 WNLAAKKAMYTL-------SAQDEVFSLAFSPNRYWLAAAT 256 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 40/270 (14%), Positives = 91/270 (33%), Gaps = 44/270 (16%) Query: 90 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYT 149 + H+ + + +G + A+ + L++ + + + + Sbjct: 62 KGHSHIVQDCTL---TADGAYALSASWDKT-LRLWDVATGETYQRFVGHKSDVMSVDI-- 115 Query: 150 CAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPR-----DPN 204 + ++ I++ I QC+ +GH + +++++ P D Sbjct: 116 -------DKKASMIISGSRDKTIKVW-TIKGQCLATLLGHNDWVSQVRVVPNEKADDDSV 167 Query: 205 LLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 ++S D ++ WN+ + A F GH + + G I S G D + LW Sbjct: 168 TIISAGNDKMVKAWNLNQFQIEADF---IGHNSNINTLTASPDGTLIASAGKDGEIMLWN 224 Query: 265 INSKRMMNAIKE-----SYDYNPNK-----TNRPFISQKIHFPDFSTRDIHRN------- 307 + +K+ M + S ++PN+ I P + D+ Sbjct: 225 LAAKKAMYTLSAQDEVFSLAFSPNRYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYSKA 284 Query: 308 ---YVDCVRWL--GDLILSKSCENAIVCWK 332 + + W G + + +N I W+ Sbjct: 285 AEPHAVSLAWSADGQTLFAGYTDNVIRVWQ 314 Score = 119 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 55/370 (14%), Positives = 115/370 (31%), Gaps = 76/370 (20%) Query: 85 VNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTL-Y-----ECHSQGEIRLLQSY 138 + E HN + + + G P + + ++ + + + +R + + Sbjct: 9 LRGTLEGHNGWVTSLA----TSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVRSFKGH 64 Query: 139 VDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKF 198 D C T D A +R+ + T + + +VGH + + + Sbjct: 65 SHIVQD-----CTLTADG----AYALSASWDKTLRLWDVATGETYQRFVGHKSDVMSVDI 115 Query: 199 HPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY------DLLGEKIM 252 + ++++S S+D +++W I+ + GH D V D I+ Sbjct: 116 D-KKASMIISGSRDKTIKVWTIKG----QCLATLLGHNDWVSQVRVVPNEKADDDSVTII 170 Query: 253 SCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCV 312 S G D +K W +N ++ T P Sbjct: 171 SAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASPD----------------------- 207 Query: 313 RWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDF 372 G LI S + I+ W + ++ T+ +Q +++ + FS + Sbjct: 208 ---GTLIASAGKDGEIMLWN----------LAAKKAMYTL-----SAQDEVFSLAFSPN- 248 Query: 373 WQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIR--QTSFSRDSSILIAVCD 430 + + V+ L+ + + A ++S D L A Sbjct: 249 --RYWLAAATATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYT 306 Query: 431 DASIWRWDRL 440 D I W + Sbjct: 307 DNVIRVWQVM 316 Score = 70.3 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 30/226 (13%), Positives = 68/226 (30%), Gaps = 62/226 (27%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTC 150 H + V + K+ ++ + + ++ + L + D + Sbjct: 105 GHKSDVMSVDID---KKASMIISGSRDKT-IKVWTIK-GQCLATLLGHNDWVSQV---RV 156 Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS 210 ++ + AG+ +++ N Q ++GH + IN L P D L+ S Sbjct: 157 VPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTASP-DGTLIASAG 215 Query: 211 KDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDL------------------------ 246 KD + LWN+ + +DEV S + Sbjct: 216 KDGEIMLWNLAAKKAMYTLSA----QDEVFSLAFSPNRYWLAAATATGIKVFSLDPQYLV 271 Query: 247 -------------------------LGEKIMSCGMDHSLKLWRINS 267 G+ + + D+ +++W++ + Sbjct: 272 DDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAGYTDNVIRVWQVMT 317 >5Y88-O nrPDB Length = 451 Score = 125 bits (312), Expect = 5e-29, Method: Composition-based stats. Identities = 42/313 (13%), Positives = 95/313 (30%), Gaps = 37/313 (11%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTC 150 H + V + E + +++ + L +V D Sbjct: 137 GHLGWVRCVAIDPVDNE---WFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAV--- 190 Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS 210 + HP L ++ + Q I+ Y GH + + + HP +L+ + Sbjct: 191 ------SDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPT-LDLIATAG 243 Query: 211 KDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRM 270 +D ++LW+++T V + GH+ + + +++S D +++LW + + + Sbjct: 244 RDSVIKLWDMRTRIPVIT---LVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKT 300 Query: 271 MNAIKESYDYNPNKTNRPFISQKIHFPDFSTR--------------DIHRNYVDCVRWLG 316 M + P R ++ + Sbjct: 301 MKVLTHHKRSVRATALHPKEFSVASACTDDIRSWGLAEGSLLTNFESEKTGIINTLSINQ 360 Query: 317 DLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKM 376 D +L +N ++ + K + E ++ G C + D Sbjct: 361 DDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGER-SVLCSTF------DKTGLR 413 Query: 377 LALGNQVGKLYVW 389 L G + +W Sbjct: 414 LITGEADKSIKIW 426 Score = 101 bits (252), Expect = 5e-22, Method: Composition-based stats. Identities = 43/262 (16%), Positives = 80/262 (30%), Gaps = 52/262 (19%) Query: 176 NPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGH 235 + + GH + + P D ++ S D +++W++ T L + GH Sbjct: 125 WHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTT---LAGH 181 Query: 236 RDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIH 295 V + S D ++K W + + N+ H Sbjct: 182 VMTVRDVAVSDRHPYLFSVSEDKTVKCWDL------------------EKNQIIRDYYGH 223 Query: 296 FPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGR 355 T IH DLI + ++ I W D+ P + V Sbjct: 224 LSGVRTVSIHPTL--------DLIATAGRDSVIKLW-------DMRTRIPVITLV----- 263 Query: 356 FDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQ 415 + I ++ + + + + +WD+ LTHHK ++R Sbjct: 264 --GHKGPINQVQCTP--VDPQVVSSSTDATVRLWDVVA----GKTMKVLTHHKR--SVRA 313 Query: 416 TSFSRDSSILIAVCDDASIWRW 437 T+ + + C D I W Sbjct: 314 TALHPKEFSVASACTDD-IRSW 334 Score = 91.9 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 31/219 (14%), Positives = 65/219 (29%), Gaps = 49/219 (22%) Query: 223 DTLVAIFGGVEGHRDEVLSADYDL-LGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN 281 + + GH V D E ++ D ++K+W + + ++ + Sbjct: 126 HAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHV--- 182 Query: 282 PNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDID 341 + D + D H + S S + + CW K Sbjct: 183 ------------MTVRDVAVSDRHP-----------YLFSVSEDKTVKCWDLEKN----- 214 Query: 342 KIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKC 401 I+ + + + ++A + + +WD+ P Sbjct: 215 ---------QIIRDYYGHLSGVRTVSIHP--TLDLIATAGRDSVIKLWDMRTRIP----V 259 Query: 402 TTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL 440 TL HK I Q + +++ DA++ WD + Sbjct: 260 ITLVGHK--GPINQVQCTPVDPQVVSSSTDATVRLWDVV 296 Score = 71.1 bits (172), Expect = 9e-13, Method: Composition-based stats. Identities = 33/247 (13%), Positives = 82/247 (33%), Gaps = 65/247 (26%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRV-TLYECHSQGEIRLLQSYVDADADENFYT 149 H + V + + AT G + V L++ ++ + L + Sbjct: 222 GHLSGVRTVSIHP-----TLDLIATAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTP 276 Query: 150 CAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSV 209 P + + + +R+ + + + +K H ++ HP++ ++ + Sbjct: 277 V---------DPQVVSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVASAC 327 Query: 210 SKDHALRLWNIQTDTLVAIFGGVE-------------------------------GHRDE 238 + D +R W + +L+ F + GH+ + Sbjct: 328 TDD--IRSWGLAEGSLLTNFESEKTGIINTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQ 385 Query: 239 ----------------VLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNP 282 VL + +D G ++++ D S+K+W+ + + + +NP Sbjct: 386 SLATREMVGSLEGERSVLCSTFDKTGLRLITGEADKSIKIWKQD-ETATKESEPGLAWNP 444 Query: 283 NKTNRPF 289 N + + F Sbjct: 445 NLSAKRF 451 >4XYI-A nrPDB Length = 430 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 48/273 (17%), Positives = 95/273 (34%), Gaps = 50/273 (18%) Query: 92 HNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECH----------SQGEIRLLQSYVDA 141 H FG+ +N+ + + + +++ + + + Sbjct: 181 HTSEGFGLGWNFIQ---EGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHRHTAV 237 Query: 142 DADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPI------TMQCIKHYVGHGNAINE 195 D F+ LL ++I + QC+K H +N Sbjct: 238 VNDLQFHL--------QHEALLTSVSDDCTLQIHDTRLPSSSSASQCVK---AHEQPVNG 286 Query: 196 LKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKI-MSC 254 + F+P + LL + S DH + LW+++ L +EGH DEV + + E I ++ Sbjct: 287 VAFNPFNDYLLATASADHTVALWDLRR--LNQRLHTLEGHEDEVYNVQWSPHDEPILVTS 344 Query: 255 GMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW 314 D + +W ++ +++S D P H N V + W Sbjct: 345 STDRRVCVWDLSKIGEEQTVEDSEDGAPEL--------------MFMHGGHTNRVSDLSW 390 Query: 315 LGD---LILSKSCENAIVCWKPGKMEDDIDKIK 344 + ++ S + +N + W P K+ D +K Sbjct: 391 NPNNKWVLASLADDNILQIWSPSKVIWASDSLK 423 Score = 71.9 bits (174), Expect = 5e-13, Method: Composition-based stats. Identities = 27/151 (17%), Positives = 62/151 (41%), Gaps = 28/151 (18%) Query: 83 KCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDAD 142 +CV + H QP+ GV FN + D L+ + V L++ + + + Sbjct: 275 QCVKA----HEQPVNGVAFNPFN---DYLLATASADHTVALWDLRRLNQ----RLHTLEG 323 Query: 143 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYV--------------G 188 ++ Y W+ P+L + + + + + + + G Sbjct: 324 HEDEVYNVQWSPH---DEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPELMFMHGG 380 Query: 189 HGNAINELKFHPRDPNLLLSVSKDHALRLWN 219 H N +++L ++P + +L S++ D+ L++W+ Sbjct: 381 HTNRVSDLSWNPNNKWVLASLADDNILQIWS 411 Score = 68.0 bits (164), Expect = 7e-12, Method: Composition-based stats. Identities = 42/260 (16%), Positives = 95/260 (36%), Gaps = 45/260 (17%) Query: 189 HGNAINELKFHPRDPNLLLSVSKDHALRLWNI---QTDTLVAIFGG--VEGHRDEVLSAD 243 H +N+ +F P++P+++ ++ + ++++ + +V + H E Sbjct: 130 HEGDVNKARFMPQNPDIIATLGLNGNGYIFDLNLYREQPIVQTGHQACLRHHTSEGFGLG 189 Query: 244 YDLLGE-KIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTR 302 ++ + E + + D S+ +W I K + ++++S D P S Sbjct: 190 WNFIQEGTLATGTEDTSICVWDIKGKSL--SLEKSIDVAP----------------VSVY 231 Query: 303 DIHRNYVDCVRW---LGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYS 359 H V+ +++ L+ S S + + D S ++ Sbjct: 232 HRHTAVVNDLQFHLQHEALLTSVSDDCTLQI-------HDTRLPSSSSAS----QCVKAH 280 Query: 360 QCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFS 419 + + + F+ F +LA + + +WDL + TL H+ + +S Sbjct: 281 EQPVNGVAFNP-FNDYLLATASADHTVALWDLRRLNQR---LHTLEGHE--DEVYNVQWS 334 Query: 420 R-DSSILIAVCDDASIWRWD 438 D IL+ D + WD Sbjct: 335 PHDEPILVTSSTDRRVCVWD 354 Score = 63.8 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 36/276 (13%), Positives = 90/276 (32%), Gaps = 62/276 (22%) Query: 182 CIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTL-------VAIFGGVEG 234 C++H H + L ++ L + ++D ++ +W+I+ +L VA Sbjct: 177 CLRH---HTSEGFGLGWNFIQEGTLATGTEDTSICVWDIKGKSLSLEKSIDVAPVSVYHR 233 Query: 235 HRDEVLSADYD-LLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQK 293 H V + + S D +L++ + S + Sbjct: 234 HTAVVNDLQFHLQHEALLTSVSDDCTLQIHDTR-------LPSSSSAS------------ 274 Query: 294 IHFPDFSTRDIHRNYVDCVRWLG---DLILSKSCENAIVCWKPGKMEDDIDKIKPSESNV 350 H V+ V + L+ + S ++ + W ++ Sbjct: 275 ------QCVKAHEQPVNGVAFNPFNDYLLATASADHTVALWDLRRLN------------- 315 Query: 351 TILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTT------- 403 L + + +++ +++S + +L + ++ VWDL + + Sbjct: 316 QRLHTLEGHEDEVYNVQWSP-HDEPILVTSSTDRRVCVWDLSKIGEEQTVEDSEDGAPEL 374 Query: 404 -LTHHKCGAAIRQTSFSRDSS-ILIAVCDDASIWRW 437 H + S++ ++ +L ++ DD + W Sbjct: 375 MFMHGGHTNRVSDLSWNPNNKWVLASLADDNILQIW 410 >3JAP-g nrPDB Length = 326 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 47/269 (17%), Positives = 91/269 (33%), Gaps = 25/269 (9%) Query: 185 HYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV--AIFGGVEGHRDEVLSA 242 GH + L PNLL+S S+D L W + + +GH V Sbjct: 13 TLEGHNGWVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSHIVQDV 72 Query: 243 DYDLLGEKIMSCGMDHSLKLWRINSK----RMMNAIKESYDYNPNKTNRPFIS----QKI 294 G +S D +L+LW + + R + + + + IS + I Sbjct: 73 VVSADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAIDANSSKIISASRDKTI 132 Query: 295 HFPDFSTRD-----IHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESN 349 + H ++V VR + ++ + + M+ + +E + Sbjct: 133 RVWNTVGDCAYVLLGHTDWVTKVRVAPKNLEDGEVDDGRITFVSAGMDKIVRSWSLNEDS 192 Query: 350 VTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKC 409 I F I ++ S D + A + G++YVW+L+ + + + Sbjct: 193 YRIEADFIGHNNYINVVQPSPD--GSLAASAGKDGQIYVWNLKHK-------SAFMNFDA 243 Query: 410 GAAIRQTSFSRDSSILIAVCDDASIWRWD 438 + +FS S + + I +D Sbjct: 244 KDEVFALAFSP-SRFWLTAATASGIKIYD 271 Score = 115 bits (286), Expect = 6e-26, Method: Composition-based stats. Identities = 59/374 (15%), Positives = 106/374 (28%), Gaps = 78/374 (20%) Query: 85 VNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSN----RVTLYECHSQGEIRLLQSYVD 140 + E HN + + + + + LV + R+T E +R + + Sbjct: 10 LRGTLEGHNG--WVTSLSTSAAQPNLLVSGSRDKTLISWRLTENEQQFGVPVRSYKGHSH 67 Query: 141 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP 200 D + A +R+ N T +VGH + + Sbjct: 68 IVQDVVV---------SADGNYAVSASWDKTLRLWNLATGNSEARFVGHTGDVLSVAID- 117 Query: 201 RDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDL---------LGEK- 250 + + ++S S+D +R+WN D + GH D V G Sbjct: 118 ANSSKIISASRDKTIRVWNTVGDCAYVLL----GHTDWVTKVRVAPKNLEDGEVDDGRIT 173 Query: 251 IMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVD 310 +S GMD ++ W +N + + H NY++ Sbjct: 174 FVSAGMDKIVRSWSLNED--------------------------SYRIEADFIGHNNYIN 207 Query: 311 CVRWL--GDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRF 368 V+ G L S + I W FD +++ + F Sbjct: 208 VVQPSPDGSLAASAGKDGQIYVWNLKHKSA--------------FMNFDAKD-EVFALAF 252 Query: 369 SMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIR--QTSFSRDSSILI 426 S + + ++DLE E + ++S D L Sbjct: 253 SPS---RFWLTAATASGIKIYDLENEVLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLF 309 Query: 427 AVCDDASIWRWDRL 440 A D I W + Sbjct: 310 AGYTDNVIRVWQVM 323 Score = 61.1 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 30/229 (13%), Positives = 68/229 (29%), Gaps = 62/229 (27%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTC 150 H + V + +S + + + + ++ +L + D Sbjct: 106 GHTGDVLSVAIDANSSK----IISASRDKTIRVWN-TVGDCAYVLLGHTDWVTKVRVAPK 160 Query: 151 AWTYDSNTSHPL-LAVAGSRGIIRII--NPITMQCIKHYVGHGNAINELKFHPRDPNLLL 207 + AG I+R N + + ++GH N IN ++ P D +L Sbjct: 161 NLEDGEVDDGRITFVSAGMDKIVRSWSLNEDSYRIEADFIGHNNYINVVQPSP-DGSLAA 219 Query: 208 SVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDL--------------------- 246 S KD + +WN++ + F +DEV + + Sbjct: 220 SAGKDGQIYVWNLKHKSAFMNFDA----KDEVFALAFSPSRFWLTAATASGIKIYDLENE 275 Query: 247 ----------------------------LGEKIMSCGMDHSLKLWRINS 267 G+ + + D+ +++W++ + Sbjct: 276 VLIDELKPEFAGYTKAQDPHAVSLAWSADGQTLFAGYTDNVIRVWQVMT 324 >3FM0-A nrPDB Length = 345 Score = 122 bits (306), Expect = 2e-28, Method: Composition-based stats. Identities = 51/317 (16%), Positives = 107/317 (33%), Gaps = 42/317 (13%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLY--ECHSQGEIRLLQSY 138 S+ C + L E H + + V ++ F ++ + L+ + Sbjct: 49 SWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTC----IWKKNQDDFECVTTLEGH 104 Query: 139 VDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM---QCIKHYVGHGNAINE 195 + + AW N LLA + + +C+ H + Sbjct: 105 -----ENEVKSVAWAPSGN----LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKH 155 Query: 196 LKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCG 255 + +HP LL S S D ++L+ + D V +EGH V S +D G+++ SC Sbjct: 156 VVWHPSQ-ELLASASYDDTVKLYREEEDDWVCC-ATLEGHESTVWSLAFDPSGQRLASCS 213 Query: 256 MDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW- 314 D ++++WR + + + P + H + + W Sbjct: 214 DDRTVRIWR-------QYLPGNEQGVACSGSDPSWK-----CICTLSGFHSRTIYDIAWC 261 Query: 315 -LGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFD-YSQCDIWYMRFSMDF 372 L + + ++AI ++ D P + ++ D+ + ++ Sbjct: 262 QLTGALATACGDDAIRVFQEDPNSD------PQQPTFSLTAHLHQAHSQDVNCVAWNPKE 315 Query: 373 WQKMLALGNQVGKLYVW 389 +LA + G++ W Sbjct: 316 PG-LLASCSDDGEVAFW 331 Score = 107 bits (267), Expect = 8e-24, Method: Composition-based stats. Identities = 61/344 (17%), Positives = 113/344 (32%), Gaps = 52/344 (15%) Query: 134 LLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQ--CIKHY-VGHG 190 +L V A D + AW + LLA G IRI C GH Sbjct: 6 VLLGRVPAHPDSRCWFLAWNP----AGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQ 61 Query: 191 NAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEK 250 + ++ + P N L S S D +W D +EGH +EV S + G Sbjct: 62 RTVRKVAWSPC-GNYLASASFDATTCIWKKNQDD-FECVTTLEGHENEVKSVAWAPSGNL 119 Query: 251 IMSCGMDHSLKLWRINSK---RMMNAIKESYD------YNPNKTNRPFISQKIHFPDF-- 299 + +C D S+ +W ++ + ++ + ++P++ S + Sbjct: 120 LATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYRE 179 Query: 300 --------STRDIHRNYVDCVRW--LGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESN 349 +T + H + V + + G + S S + + W+ + +E Sbjct: 180 EEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQY--------LPGNEQG 231 Query: 350 VTILGRFDYSQCDIWYMRFSMDFWQKM--------LALGNQVGKLYVWDLEVEDPHKAKC 401 V G +C F + LA + V+ + + Sbjct: 232 VACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPT 291 Query: 402 TTLT---HHKCGAAIRQTSFSRDSSILIAVCDDA---SIWRWDR 439 +LT H + +++ L+A C D + W++ R Sbjct: 292 FSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQR 335 Score = 50.3 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 29/160 (18%), Positives = 50/160 (31%), Gaps = 31/160 (19%) Query: 84 CVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR-VTLYE-----CHSQGEIRLLQS 137 C +L E H ++ + F+ + A+ +R V ++ Sbjct: 186 CCATL-EGHESTVWSLAFDPSGQR-----LASCSDDRTVRIWRQYLPGNEQGVACSGSDP 239 Query: 138 ------YVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRII----NPITMQCIKHYV 187 + Y AW + LA A IR+ N Q Sbjct: 240 SWKCICTLSGFHSRTIYDIAWCQLTGA----LATACGDDAIRVFQEDPNSDPQQPTFSLT 295 Query: 188 GHGN-----AINELKFHPRDPNLLLSVSKDHALRLWNIQT 222 H + +N + ++P++P LL S S D + W Q Sbjct: 296 AHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQR 335 >5WJC-A nrPDB Length = 430 Score = 122 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 50/270 (18%), Positives = 93/270 (34%), Gaps = 46/270 (17%) Query: 90 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRV-TLYECHSQG----------EIRLLQSY 138 + H FG+ +N + AT ++V L++ +Q I + Sbjct: 179 KGHTAEGFGLCWNPNLPGN----LATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRH 234 Query: 139 VDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPI---TMQCIKHYVGHGNAINE 195 D D F+ LLA ++I + + K H AIN Sbjct: 235 TDIVNDVQFHP--------QHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINA 286 Query: 196 LKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIM-SC 254 + +P + LL + S D + LW+++ +EGH DEV ++ E I+ S Sbjct: 287 VAINPFNDYLLATASADKTVALWDLRN--PYQRLHTLEGHEDEVYGLEWSPHDEPILASS 344 Query: 255 GMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW 314 D + +W + +++ D +P H N + W Sbjct: 345 STDRRVCIWDLEKIGEEQTPEDAEDGSPEL--------------LFMHGGHTNRISEFSW 390 Query: 315 LGD---LILSKSCENAIVCWKPGKMEDDID 341 + ++ S + +N + W P ++ D Sbjct: 391 CPNERWVVGSLADDNILQIWSPSRVIWGRD 420 Score = 34.9 bits (78), Expect = 0.079, Method: Composition-based stats. Identities = 27/194 (13%), Positives = 75/194 (38%), Gaps = 18/194 (9%) Query: 253 SCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCV 312 + G D +I S ++ N +++ ++ P+ T R + + + S + H V+ Sbjct: 81 TSGNDQ--NYLQIASVQLPNFDEDTTEFTPS-TIRRAQATGSYTIEISQKIPHDGDVNRA 137 Query: 313 RWLGD---LILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFS 369 R++ +I + D + E+ + + ++ + + ++ Sbjct: 138 RYMPQKPEIIATMGEGGN----AYIFDTTCHDALTTGEALPQAVLKGHTAEG--FGLCWN 191 Query: 370 MDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLT----HHKCGAAIRQTSFSRD-SSI 424 + LA G + + +WD++ + ++ ++ +H+ + F ++ Sbjct: 192 PNLPGN-LATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEAL 250 Query: 425 LIAVCDDASIWRWD 438 L +V DD ++ D Sbjct: 251 LASVSDDCTLQIHD 264 >6Q8F-A nrPDB Length = 514 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 52/326 (15%), Positives = 111/326 (34%), Gaps = 29/326 (8%) Query: 79 KYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSY 138 K+ + +K + +F+ +G LV +V + ++ + + L+ Sbjct: 201 KFPTQLSRHIKFGQKSHVECARFSP---DGQYLVTGSVD-GFIEVWNFTTGKIRKDLKYQ 256 Query: 139 VDADA---DENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYV-GHGNAIN 194 + D+ ++ D+ +LA G I++ + QC++ + H + Sbjct: 257 AQDNFMMMDDAVLCMCFSRDT----EMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVT 312 Query: 195 ELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSC 254 L F +D + +LS S D +R+ +++ GH V A + G I+S Sbjct: 313 CLSFS-KDSSQILSASFDQTIRIHGLKSG---KTLKEFRGHSSFVNEATFTQDGHYIISA 368 Query: 255 GMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW 314 D ++K+W + + N K + P+ N V + Sbjct: 369 SSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNM 428 Query: 315 LGDLILSKS-----------CENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDI 363 G ++ S S C + + +D S + + D+ Sbjct: 429 QGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDV 488 Query: 364 WYMRFSMDFWQKMLALGNQVGKLYVW 389 + Q ++A ++ G L +W Sbjct: 489 IGIAHHPH--QNLIATYSEDGLLKLW 512 Score = 83.1 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 39/293 (13%), Positives = 80/293 (27%), Gaps = 56/293 (19%) Query: 152 WTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNA-----INELKFHPRDPNLL 206 W P + + RG + + + H + +F P D L Sbjct: 172 WQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSP-DGQYL 230 Query: 207 LSVSKDHALRLWNIQTDTLVAIFG-----GVEGHRDEVLSADYDLLGEKIMSCGMDHSLK 261 ++ S D + +WN T + D VL + E + + D +K Sbjct: 231 VTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIK 290 Query: 262 LWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL--GDLI 319 +W+I S + + + H V C+ + I Sbjct: 291 VWKIQSGQCLRRFE---------------------------RAHSKGVTCLSFSKDSSQI 323 Query: 320 LSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLAL 379 LS S + I + L F + F+ D + Sbjct: 324 LSASFDQTIRI--------------HGLKSGKTLKEFRGHSSFVNEATFTQD--GHYIIS 367 Query: 380 GNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDA 432 + G + +W+++ + + + + + VC+ + Sbjct: 368 ASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRS 420 Score = 81.5 bits (199), Expect = 7e-16, Method: Composition-based stats. Identities = 41/269 (15%), Positives = 92/269 (34%), Gaps = 47/269 (17%) Query: 71 GKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQG 130 GK K K + S +C+ + H++ + + F+ S + + + + ++ S Sbjct: 287 GKIKVWKIQ-SGQCLRRFERAHSKGVTCLSFSKDSSQ----ILSASFDQTIRIHGLKSGK 341 Query: 131 EIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYV--- 187 ++ + + + F + A S G ++I N T +C + Sbjct: 342 TLKEFRGHSSFVNEATF---------TQDGHYIISASSDGTVKIWNMKTTECSNTFKSLG 392 Query: 188 ---GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY 244 G +N + P++P + ++ + + + N+Q +V F + + + Sbjct: 393 STAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQ-GQIVRSFSSGKREGGDFVCCAL 451 Query: 245 DLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDI 304 GE I G D L + + ++ + +H D Sbjct: 452 SPRGEWIYCVGEDFVLYCFSTVTGKLERTL------------------TVHEKDVIGIAH 493 Query: 305 HRNYVDCVRWLGDLILSKSCENAIVCWKP 333 H + +LI + S + + WKP Sbjct: 494 HPH--------QNLIATYSEDGLLKLWKP 514 Score = 74.2 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 29/208 (13%), Positives = 71/208 (34%), Gaps = 45/208 (21%) Query: 234 GHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQK 293 G + V A + G+ +++ +D +++W + ++ +K N + Sbjct: 213 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMD------- 265 Query: 294 IHFPDFSTRDIHRNYVDCVRWLGD--LILSKSCENAIVCWKPGKMEDDIDKIKPSESNVT 351 + V C+ + D ++ + + + I WK + Sbjct: 266 -------------DAVLCMCFSRDTEMLATGAQDGKIKVWK--------------IQSGQ 298 Query: 352 ILGRFD-YSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCG 410 L RF+ + + FS D Q + A +Q +++ H Sbjct: 299 CLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIH------GLKSGKTLKEFRGHSSF 352 Query: 411 AAIRQTSFSRDSSILIAVCDDASIWRWD 438 + + +F++D +I+ D ++ W+ Sbjct: 353 --VNEATFTQDGHYIISASSDGTVKIWN 378 >5Z56-q nrPDB Length = 504 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 43/281 (15%), Positives = 88/281 (31%), Gaps = 55/281 (19%) Query: 158 TSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRL 217 + + G+ + + + + Q + GH + + FHP +L+ S S D +R+ Sbjct: 232 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQ-DLVFSASPDATIRI 290 Query: 218 WNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLW---RINSKRMMNAI 274 W++ + V + V H V G+ ++S D W I + R++ + Sbjct: 291 WSVPNASCVQV---VRAHESAVTGLSLHATGDYLLSSSDDQ---YWAFSDIQTGRVLTKV 344 Query: 275 KESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPG 334 + + H + G + + + ++ I W Sbjct: 345 TDETSG----------------CSLTCAQFHPD--------GLIFGTGTMDSQIKIW--- 377 Query: 335 KMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVE 394 D+ + + F I + FS + LA + +WDL Sbjct: 378 ----DLKERTN-------VANFPGHSGPITSIAFSEN--GYYLATAADDSSVKLWDL--- 421 Query: 395 DPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIW 435 K K ++ F + + L D I+ Sbjct: 422 --RKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIY 460 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 43/272 (15%), Positives = 90/272 (33%), Gaps = 56/272 (20%) Query: 174 IINPITMQCIKHYVGHGN-------AINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV 226 ++ P + + H I L P D N +L+ D + +++ + Sbjct: 198 LVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFD---KSSE 254 Query: 227 AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTN 286 I ++GH +V S + + + S D ++++W + + + ++ Sbjct: 255 QILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESA------ 308 Query: 287 RPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPS 346 + +H GD +LS S + W ++ K + Sbjct: 309 ------------VTGLSLHA--------TGDYLLSSSDD---QYWAFSDIQTGRVLTKVT 345 Query: 347 ESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTH 406 + + S C + +F D + G ++ +WDL+ + Sbjct: 346 D---------ETSGCSLTCAQFHPDGL--IFGTGTMDSQIKIWDLK----ERTNVANFPG 390 Query: 407 HKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 H I +FS + L DD+S+ WD Sbjct: 391 HS--GPITSIAFSENGYYLATAADDSSVKLWD 420 Score = 91.5 bits (225), Expect = 6e-19, Method: Composition-based stats. Identities = 38/279 (13%), Positives = 80/279 (28%), Gaps = 70/279 (25%) Query: 112 VFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGI 171 + V +++ S+ + L+ + F + S L+ A Sbjct: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVF---------HPSQDLVFSASPDAT 287 Query: 172 IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLS----------------------- 208 IRI + C++ H +A+ L H LL S Sbjct: 288 IRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDE 347 Query: 209 --------------------VSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLG 248 + D +++W+++ T VA F GH + S + G Sbjct: 348 TSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANF---PGHSGPITSIAFSENG 404 Query: 249 EKIMSCGMDHSLKLWRINSKRMMNAIK--ESYDYNPNKTNRPFISQKIHFPDFSTR---- 302 + + D S+KLW + + ++ +++ ++ + D Sbjct: 405 YYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQ 464 Query: 303 -------DIHRNYVDCVRWL--GDLILSKSCENAIVCWK 332 H V + I S + ++ + Sbjct: 465 WTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYS 503 Score = 82.3 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 33/251 (13%), Positives = 76/251 (30%), Gaps = 47/251 (18%) Query: 79 KYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSY 138 K S + + +LK H + + V F+ LVF+ + ++ + +++++++ Sbjct: 251 KSSEQILATLK-GHTKKVTSVVFHPSQD----LVFSASPDATIRIWSVPNASCVQVVRAH 305 Query: 139 VDADADENFYTCA-----------WTYDSNTSHPLLA----------------------- 164 A + + W + + +L Sbjct: 306 ESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIF 365 Query: 165 -VAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTD 223 I+I + + ++ GH I + F + L + + D +++LW+++ Sbjct: 366 GTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFS-ENGYYLATAADDSSVKLWDLRKL 424 Query: 224 TLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSL---KLWRINSKRMMNAIKESYDY 280 EV S +D G + G D + K W + Sbjct: 425 KNFKTLQLDN--NFEVKSLIFDQSGTYLALGGTDVQIYICKQW-TEILHFTEHSGLTTGV 481 Query: 281 NPNKTNRPFIS 291 + S Sbjct: 482 AFGHHAKFIAS 492 >4LG8-A nrPDB Length = 354 Score = 118 bits (294), Expect = 6e-27, Method: Composition-based stats. Identities = 43/281 (15%), Positives = 88/281 (31%), Gaps = 55/281 (19%) Query: 158 TSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRL 217 + + G+ + + + + Q + GH + + FHP +L+ S S D +R+ Sbjct: 82 SDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQ-DLVFSASPDATIRI 140 Query: 218 WNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLW---RINSKRMMNAI 274 W++ + V + V H V G+ ++S D W I + R++ + Sbjct: 141 WSVPNASCVQV---VRAHESAVTGLSLHATGDYLLSSSDDQ---YWAFSDIQTGRVLTKV 194 Query: 275 KESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPG 334 + + H + G + + + ++ I W Sbjct: 195 TDETSG----------------CSLTCAQFHPD--------GLIFGTGTMDSQIKIW--- 227 Query: 335 KMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVE 394 D+ + + F I + FS + LA + +WDL Sbjct: 228 ----DLKERTN-------VANFPGHSGPITSIAFSEN--GYYLATAADDSSVKLWDL--- 271 Query: 395 DPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIW 435 K K ++ F + + L D I+ Sbjct: 272 --RKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIY 310 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 43/272 (15%), Positives = 90/272 (33%), Gaps = 56/272 (20%) Query: 174 IINPITMQCIKHYVGHGN-------AINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV 226 ++ P + + H I L P D N +L+ D + +++ + Sbjct: 48 LVKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFD---KSSE 104 Query: 227 AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTN 286 I ++GH +V S + + + S D ++++W + + + ++ Sbjct: 105 QILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESA------ 158 Query: 287 RPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPS 346 + +H GD +LS S + W ++ K + Sbjct: 159 ------------VTGLSLHA--------TGDYLLSSSDD---QYWAFSDIQTGRVLTKVT 195 Query: 347 ESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTH 406 + + S C + +F D + G ++ +WDL+ + Sbjct: 196 D---------ETSGCSLTCAQFHPDGL--IFGTGTMDSQIKIWDLK----ERTNVANFPG 240 Query: 407 HKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 H I +FS + L DD+S+ WD Sbjct: 241 HS--GPITSIAFSENGYYLATAADDSSVKLWD 270 Score = 90.0 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 38/279 (13%), Positives = 80/279 (28%), Gaps = 70/279 (25%) Query: 112 VFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGI 171 + V +++ S+ + L+ + F + S L+ A Sbjct: 87 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVF---------HPSQDLVFSASPDAT 137 Query: 172 IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLS----------------------- 208 IRI + C++ H +A+ L H LL S Sbjct: 138 IRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDE 197 Query: 209 --------------------VSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLG 248 + D +++W+++ T VA F GH + S + G Sbjct: 198 TSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANF---PGHSGPITSIAFSENG 254 Query: 249 EKIMSCGMDHSLKLWRINSKRMMNAIK--ESYDYNPNKTNRPFISQKIHFPDFSTR---- 302 + + D S+KLW + + ++ +++ ++ + D Sbjct: 255 YYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQ 314 Query: 303 -------DIHRNYVDCVRWL--GDLILSKSCENAIVCWK 332 H V + I S + ++ + Sbjct: 315 WTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYS 353 Score = 81.1 bits (198), Expect = 9e-16, Method: Composition-based stats. Identities = 33/251 (13%), Positives = 76/251 (30%), Gaps = 47/251 (18%) Query: 79 KYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSY 138 K S + + +LK H + + V F+ LVF+ + ++ + +++++++ Sbjct: 101 KSSEQILATLK-GHTKKVTSVVFHPSQD----LVFSASPDATIRIWSVPNASCVQVVRAH 155 Query: 139 VDADADENFYTCA-----------WTYDSNTSHPLLA----------------------- 164 A + + W + + +L Sbjct: 156 ESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIF 215 Query: 165 -VAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTD 223 I+I + + ++ GH I + F + L + + D +++LW+++ Sbjct: 216 GTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFS-ENGYYLATAADDSSVKLWDLRKL 274 Query: 224 TLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSL---KLWRINSKRMMNAIKESYDY 280 EV S +D G + G D + K W + Sbjct: 275 KNFKTLQLDN--NFEVKSLIFDQSGTYLALGGTDVQIYICKQW-TEILHFTEHSGLTTGV 331 Query: 281 NPNKTNRPFIS 291 + S Sbjct: 332 AFGHHAKFIAS 342 >5WLC-LO nrPDB Length = 923 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 48/303 (15%), Positives = 104/303 (34%), Gaps = 29/303 (9%) Query: 157 NTSHPLLAVAGSR-GIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHAL 215 N + LA S+ G + + + I GH ++ N L + P D + +++ S+D + Sbjct: 311 NQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSP-DGSRVVTASEDGKI 369 Query: 216 RLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK 275 ++W+I + +A F H V + + G+ + S +D +++ W + R Sbjct: 370 KVWDITSGFCLATFEE---HTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFT 426 Query: 276 ESYDYNPNKTNRPFIS----------QKIHFPDFSTR------DIHRNYVDCVRWLG--D 317 + N IH T H V C+ + Sbjct: 427 GTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENS 486 Query: 318 LILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKML 377 ++ S S + I W ++ I+ + + R D + + ++ + + Sbjct: 487 VLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNIED 546 Query: 378 A--LGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIW 435 A +GN + + + + +S D ++A ++ SI Sbjct: 547 AKQVGNIDCRKDI--ISGRFNQDRFTAKNSERSKFFT--TIHYSFDGMAIVAGGNNNSIC 602 Query: 436 RWD 438 +D Sbjct: 603 LYD 605 Score = 101 bits (251), Expect = 7e-22, Method: Composition-based stats. Identities = 59/362 (16%), Positives = 121/362 (33%), Gaps = 47/362 (12%) Query: 87 SLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADEN 146 + + +H + + + N K+G L+ I + + N Sbjct: 49 TFEYEHRKNIAAIDLN---KQGTLLISI-----------DEDGRAILVNFKARNVLHHFN 94 Query: 147 FYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYV---------GHGNAINELK 197 F + L A+A R ++I + + + GH I L Sbjct: 95 FKEKCSAVKFSPDGRLFALASGRF-LQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLT 153 Query: 198 FHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMD 257 + +D +L+ SKD + ++W++ ++ GHRD V+ A + EKI + D Sbjct: 154 WS-QDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKD 212 Query: 258 HSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGD 317 ++ +W +KR + + + + ++ V CV + Sbjct: 213 GAVFVWEF-TKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHP- 270 Query: 318 LILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKML 377 A G + + T++ + Q + S++ + L Sbjct: 271 ---------ATRLLAVGFTSGEFRLYDLPD--FTLIQQLSMGQNPVN--TVSVNQTGEWL 317 Query: 378 ALGNQV-GKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWR 436 A G+ G+L V++ + E L + ++S D S ++ +D I Sbjct: 318 AFGSSKLGQLLVYEWQSES------YILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKV 371 Query: 437 WD 438 WD Sbjct: 372 WD 373 Score = 100 bits (248), Expect = 1e-21, Method: Composition-based stats. Identities = 43/248 (17%), Positives = 83/248 (33%), Gaps = 55/248 (22%) Query: 82 FKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDA 141 F + L N P+ V N + G+ L F + ++ +YE S+ I Q + D+ Sbjct: 292 FTLIQQLSMGQN-PVNTVSVN---QTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDS 347 Query: 142 DADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPR 201 + A++ D + + A G I++ + + C+ + H +++ ++F R Sbjct: 348 TN-----SLAYSPDGSR----VVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKR 398 Query: 202 DPNLLLSVSKDHALRLWNIQTDTLVAIFGGVE---------------------------- 233 ++ S S D +R W++ F G E Sbjct: 399 -GQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHV 457 Query: 234 -------------GHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDY 280 GH V + + S D ++++W I + E Y Sbjct: 458 WSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSD 517 Query: 281 NPNKTNRP 288 + RP Sbjct: 518 VLALSMRP 525 Score = 99.6 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 50/284 (17%), Positives = 105/284 (36%), Gaps = 55/284 (19%) Query: 157 NTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALR 216 + + LLAV + G R+ + I+ N +N + + L SK L Sbjct: 269 HPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLL 328 Query: 217 LWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE 276 ++ Q++ + +GH D S Y G ++++ D +K+W I S + +E Sbjct: 329 VYEWQSE---SYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEE 385 Query: 277 SYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWKPG 334 H + V V++ G ++ S S + + W Sbjct: 386 ----------------------------HTSSVTAVQFAKRGQVMFSSSLDGTVRAW--- 414 Query: 335 KMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVG-KLYVWDLEV 393 D+ + + F ++ I + ++D +++ G+ ++VW ++ Sbjct: 415 ----DLIRYRN-------FRTFTGTE-RIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQT 462 Query: 394 EDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 L+ H+ + SFS+++S+L + D +I W Sbjct: 463 ----GQLLDALSGHE--GPVSCLSFSQENSVLASASWDKTIRIW 500 >4V7E-Bg nrPDB Length = 380 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 51/323 (15%), Positives = 102/323 (31%), Gaps = 51/323 (15%) Query: 124 YECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCI 183 + R LQ + Y+ WT + N + A G + + N +T Q Sbjct: 51 FNPTDLVCCRTLQGH-----SGKVYSLDWTPEKN----WIVSASQDGRLIVWNALTSQKT 101 Query: 184 KHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI----QTDTLVAIFGGVEGHRDEV 239 H + E F P + + D A ++N+ D + + + GH+ Sbjct: 102 HAIKLHCPWVMECAFAP-NGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYA 160 Query: 240 LSADYDLLGE-KIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPD 298 S Y E ++++ D + LW + + + FP Sbjct: 161 SSCQYVPDQETRLITGSGDQTCVLWDVTTGQ------------------RISIFGSEFPS 202 Query: 299 FSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDY 358 T D+ ++ + ++ +S SC+ + W + + Sbjct: 203 GHTADVLSLSINSLN--ANMFISGSCDTTVRLWDLRITSRAVR-------------TYHG 247 Query: 359 SQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAI-RQTS 417 + DI ++F D + G+ G ++D+ + + I + Sbjct: 248 HEGDINSVKFFPD--GQRFGTGSDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVA 305 Query: 418 FSRDSSILIAVCDDASIWRWDRL 440 FS +L A + + WD L Sbjct: 306 FSISGRLLFAGYSNGDCYVWDTL 328 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 34/322 (10%), Positives = 92/322 (28%), Gaps = 80/322 (24%) Query: 84 CVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD--- 140 C +L+ H+ ++ + + + + R+ ++ + + ++ + Sbjct: 58 CCRTLQ-GHSGKVYSLDWTPEKN----WIVSASQDGRLIVWNALTSQKTHAIKLHCPWVM 112 Query: 141 -------------ADADENFYTCAWTYDSNTSHPL------------------------- 162 D + ++ + Sbjct: 113 ECAFAPNGQSVACGGLDSACSIFNLSSQADRDGNMPVSRVLTGHKGYASSCQYVPDQETR 172 Query: 163 LAVAGSRGIIRIINPITMQCIKHY-----VGHGNAINELKFHPRDPNLLLSVSKDHALRL 217 L + + T Q I + GH + L + + N+ +S S D +RL Sbjct: 173 LITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSLSINSLNANMFISGSCDTTVRL 232 Query: 218 WNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSK--------- 268 W+++ GH ++ S + G++ + D + +L+ + + Sbjct: 233 WDLR--ITSRAVRTYHGHEGDINSVKFFPDGQRFGTGSDDGTCRLFDMRTGHQLQVYNRE 290 Query: 269 --RMMNAIKESYDYNPNKTNRPF----ISQKIHFPDF----------STRDIHRNYVDCV 312 R N + + + R + + D + ++ H + C+ Sbjct: 291 PDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDTLLAEMVLNLGTLQNSHEGRISCL 350 Query: 313 RWL--GDLILSKSCENAIVCWK 332 G + + S + + W Sbjct: 351 GLSSDGSALCTGSWDKNLKIWA 372 Score = 85.0 bits (208), Expect = 7e-17, Method: Composition-based stats. Identities = 30/230 (13%), Positives = 66/230 (28%), Gaps = 58/230 (25%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTC 150 H Q + + + + G L++ + I + S + + + Sbjct: 155 GHKGYASSCQ---YVPDQETRLITGSGDQTCVLWDVTTGQRISIFGSEFPSGHTADVLSL 211 Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINP-ITMQCIKHYVGHGNAINELKFHPRDPNLLLSV 209 + + + + +R+ + IT + ++ Y GH IN +KF P D + Sbjct: 212 SIN---SLNANMFISGSCDTTVRLWDLRITSRAVRTYHGHEGDINSVKFFP-DGQRFGTG 267 Query: 210 SKDHALRLWNIQTDTLVAIFGGVE------------------------------------ 233 S D RL++++T + ++ Sbjct: 268 SDDGTCRLFDMRTGHQLQVYNREPDRNDNELPIVTSVAFSISGRLLFAGYSNGDCYVWDT 327 Query: 234 --------------GHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKR 269 H + G + + D +LK+W + R Sbjct: 328 LLAEMVLNLGTLQNSHEGRISCLGLSSDGSALCTGSWDKNLKIWAFSGHR 377 >5I2T-A nrPDB Length = 742 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 48/303 (15%), Positives = 104/303 (34%), Gaps = 29/303 (9%) Query: 157 NTSHPLLAVAGSR-GIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHAL 215 N + LA S+ G + + + I GH ++ N L + P D + +++ S+D + Sbjct: 336 NQTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDSTNSLAYSP-DGSRVVTASEDGKI 394 Query: 216 RLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK 275 ++W+I + +A F H V + + G+ + S +D +++ W + R Sbjct: 395 KVWDITSGFCLATFEE---HTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNFRTFT 451 Query: 276 ESYDYNPNKTNRPFIS----------QKIHFPDFST------RDIHRNYVDCVRWLG--D 317 + N IH T H V C+ + Sbjct: 452 GTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGHEGPVSCLSFSQENS 511 Query: 318 LILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKML 377 ++ S S + I W ++ I+ + + R D + + ++ + + Sbjct: 512 VLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALSMRPDGKEVAVSTLKGQISIFNIED 571 Query: 378 A--LGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIW 435 A +GN + + + + +S D ++A ++ SI Sbjct: 572 AKQVGNIDCRKDI--ISGRFNQDRFTAKNSERSKFFT--TIHYSFDGMAIVAGGNNNSIC 627 Query: 436 RWD 438 +D Sbjct: 628 LYD 630 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 59/362 (16%), Positives = 121/362 (33%), Gaps = 47/362 (12%) Query: 87 SLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADEN 146 + + +H + + + N K+G L+ I + + N Sbjct: 74 TFEYEHRKNIAAIDLN---KQGTLLISI-----------DEDGRAILVNFKARNVLHHFN 119 Query: 147 FYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYV---------GHGNAINELK 197 F + L A+A R ++I + + + GH I L Sbjct: 120 FKEKCSAVKFSPDGRLFALASGRF-LQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITSLT 178 Query: 198 FHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMD 257 + +D +L+ SKD + ++W++ ++ GHRD V+ A + EKI + D Sbjct: 179 WS-QDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSHDQEKIYTVSKD 237 Query: 258 HSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGD 317 ++ +W +KR + + + + ++ V CV + Sbjct: 238 GAVFVWEF-TKRPSDDDDNESEDDDKQEEVDISKYSWRITKKHFFYANQAKVKCVTFHP- 295 Query: 318 LILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKML 377 A G + + T++ + Q + S++ + L Sbjct: 296 ---------ATRLLAVGFTSGEFRLYDLPD--FTLIQQLSMGQNPVN--TVSVNQTGEWL 342 Query: 378 ALGNQV-GKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWR 436 A G+ G+L V++ + E L + ++S D S ++ +D I Sbjct: 343 AFGSSKLGQLLVYEWQSES------YILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKV 396 Query: 437 WD 438 WD Sbjct: 397 WD 398 Score = 100 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 43/248 (17%), Positives = 83/248 (33%), Gaps = 55/248 (22%) Query: 82 FKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDA 141 F + L N P+ V N + G+ L F + ++ +YE S+ I Q + D+ Sbjct: 317 FTLIQQLSMGQN-PVNTVSVN---QTGEWLAFGSSKLGQLLVYEWQSESYILKQQGHFDS 372 Query: 142 DADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPR 201 + A++ D + + A G I++ + + C+ + H +++ ++F R Sbjct: 373 TN-----SLAYSPDGSR----VVTASEDGKIKVWDITSGFCLATFEEHTSSVTAVQFAKR 423 Query: 202 DPNLLLSVSKDHALRLWNIQTDTLVAIFGGVE---------------------------- 233 ++ S S D +R W++ F G E Sbjct: 424 -GQVMFSSSLDGTVRAWDLIRYRNFRTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHV 482 Query: 234 -------------GHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDY 280 GH V + + S D ++++W I + E Y Sbjct: 483 WSVQTGQLLDALSGHEGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSD 542 Query: 281 NPNKTNRP 288 + RP Sbjct: 543 VLALSMRP 550 Score = 98.9 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 50/284 (17%), Positives = 105/284 (36%), Gaps = 55/284 (19%) Query: 157 NTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALR 216 + + LLAV + G R+ + I+ N +N + + L SK L Sbjct: 294 HPATRLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSSKLGQLL 353 Query: 217 LWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE 276 ++ Q++ + +GH D S Y G ++++ D +K+W I S + +E Sbjct: 354 VYEWQSE---SYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVWDITSGFCLATFEE 410 Query: 277 SYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWKPG 334 H + V V++ G ++ S S + + W Sbjct: 411 ----------------------------HTSSVTAVQFAKRGQVMFSSSLDGTVRAW--- 439 Query: 335 KMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVG-KLYVWDLEV 393 D+ + + F ++ I + ++D +++ G+ ++VW ++ Sbjct: 440 ----DLIRYRN-------FRTFTGTE-RIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQT 487 Query: 394 EDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 L+ H+ + SFS+++S+L + D +I W Sbjct: 488 ----GQLLDALSGHE--GPVSCLSFSQENSVLASASWDKTIRIW 525 >6N9G-C nrPDB Length = 353 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 32/190 (16%), Positives = 63/190 (33%), Gaps = 22/190 (11%) Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPR-DPNLLLSVSKDHALRLWNI 220 + A G + + + Q ++ + GHG + L P N +S D +W++ Sbjct: 167 QILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDM 226 Query: 221 QTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMN-------- 272 ++ V F H +V S Y G+ S D + +L+ + + R + Sbjct: 227 RSGQCVQAFET---HESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESII 283 Query: 273 --------AIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDL--ILSK 322 ++ + + + S H N V +R D S Sbjct: 284 FGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSG 343 Query: 323 SCENAIVCWK 332 S ++ + W Sbjct: 344 SWDHTLRVWA 353 Score = 99.6 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 36/213 (16%), Positives = 67/213 (31%), Gaps = 53/213 (24%) Query: 92 HNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCA 151 H L F D + G L++ S ++ + AD A Sbjct: 152 HTNYLSACSFT----NSDMQILTASGDGTCALWDVESGQLLQSFHGH---GADVLCLDLA 204 Query: 152 WTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSK 211 + NT G + + + QC++ + H + +N ++++P + S S Sbjct: 205 PSETGNT----FVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPS-GDAFASGSD 259 Query: 212 DHALRLWNIQTDTLVAIFGG---------------------------------------- 231 D RL++++ D VAI+ Sbjct: 260 DATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVS 319 Query: 232 -VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLW 263 + GH + V + G S DH+L++W Sbjct: 320 ILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352 Score = 91.9 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 50/255 (19%), Positives = 88/255 (34%), Gaps = 60/255 (23%) Query: 189 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSAD--YDL 246 H N ++ F D +L+ S D LW++++ L+ F GH +VL D Sbjct: 152 HTNYLSACSFTNSDM-QILTASGDGTCALWDVESGQLLQSF---HGHGADVLCLDLAPSE 207 Query: 247 LGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHR 306 G +S G D +W + S + + H Sbjct: 208 TGNTFVSGGCDKKAMVWDMRSGQC----------------------------VQAFETHE 239 Query: 307 NYVDCVRWL--GDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIW 364 + V+ VR+ GD S S + + D+ + V I YS+ I Sbjct: 240 SDVNSVRYYPSGDAFASGSDDATCRLY-------DLRA----DREVAI-----YSKESII 283 Query: 365 YMRFSMDFW--QKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDS 422 + S+DF ++L G + VWD+ ++ + L H+ + S D Sbjct: 284 FGASSVDFSLSGRLLFAGYNDYTINVWDV----LKGSRVSILFGHE--NRVSTLRVSPDG 337 Query: 423 SILIAVCDDASIWRW 437 + + D ++ W Sbjct: 338 TAFCSGSWDHTLRVW 352 Score = 86.1 bits (211), Expect = 2e-17, Method: Composition-based stats. Identities = 39/261 (14%), Positives = 77/261 (29%), Gaps = 48/261 (18%) Query: 180 MQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEV 239 M+ + GHGN + + + +D ++S S+D + +W+ T V V Sbjct: 53 MKTRRTLKGHGNKVLCMDWC-KDKRRIVSSSQDGKVIVWDSFT---TNKEHAVTMPCTWV 108 Query: 240 LSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDF 299 ++ Y G I G+D+ ++ + + N + Sbjct: 109 MACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVA------------------ 150 Query: 300 STRDIHRNYVDCVRWLGD--LILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFD 357 +H NY+ + IL+ S + W + +L F Sbjct: 151 ----MHTNYLSACSFTNSDMQILTASGDGTCALWD--------------VESGQLLQSFH 192 Query: 358 YSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTS 417 D+ + + G K VWD+ H+ + Sbjct: 193 GHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMR----SGQCVQAFETHESD--VNSVR 246 Query: 418 FSRDSSILIAVCDDASIWRWD 438 + + DDA+ +D Sbjct: 247 YYPSGDAFASGSDDATCRLYD 267 >6EOJ-D nrPDB Length = 470 Score = 110 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 55/319 (17%), Positives = 103/319 (32%), Gaps = 36/319 (11%) Query: 82 FKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDA 141 F ++S K H P +Q+ + + S +L+ S L+Q++ A Sbjct: 84 FTHLSSNKVKHVIP--AIQWTPEGRR----LVVATYSGEFSLWNASSFTFETLMQAHDSA 137 Query: 142 DADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPR 201 T + + + G+I+I P + H +I ++ F Sbjct: 138 VT---------TMKYSHDSDWMISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSN 188 Query: 202 DPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLK 261 D ++ S D+ L++WN + + GH +V S D+ I S D+ +K Sbjct: 189 DSKF-VTCSDDNILKIWNFSNGKQERV---LSGHHWDVKSCDWHPEMGLIASASKDNLVK 244 Query: 262 LWRINSKRMMNAIKES------YDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL 315 LW S +++I + + P K N K + CVR Sbjct: 245 LWDPRSGNCISSILKFKHTVLKTRFQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDE 304 Query: 316 GDLIL-----SKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSM 370 D + + C+ D+ + N IL I + ++ Sbjct: 305 TDYMTLEWHPINESMFTLACYDGSLKHFDLLQ----NLNEPILTIPYAHDKCITSLSYNP 360 Query: 371 DFWQKMLALGNQVGKLYVW 389 + A + + W Sbjct: 361 --VGHIFATAAKDRTIRFW 377 Score = 77.3 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 48/288 (16%), Positives = 106/288 (36%), Gaps = 40/288 (13%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 140 +F V + H + + + F+ D N + ++ + + R+L + Sbjct: 165 NFSMVKEIDAAHTESIRDMAFS----SNDSKFVTCSDDNILKIWNFSNGKQERVLSGHHW 220 Query: 141 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP 200 +C W + L+A A ++++ +P + CI + + + + +F P Sbjct: 221 DVK-----SCDWHPE----MGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTRFQP 271 Query: 201 RDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMS-CGMDHS 259 NLL+++SKD + R+++I+ + V D ++ ++ + E + + D S Sbjct: 272 TKGNLLMAISKDKSCRVFDIR--YSMKELMCVRDETDY-MTLEWHPINESMFTLACYDGS 328 Query: 260 LKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLI 319 LK + + + + E P ++ S +G + Sbjct: 329 LKHFDL-----LQNLNEPILTIPYAHDKCITS------------------LSYNPVGHIF 365 Query: 320 LSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMR 367 + + + I W + D P+ +N I G F DI +R Sbjct: 366 ATAAKDRTIRFWTRARPIDPNAYDDPTYNNKKINGWFFGINNDINAVR 413 Score = 65.3 bits (157), Expect = 5e-11, Method: Composition-based stats. Identities = 54/296 (18%), Positives = 95/296 (32%), Gaps = 53/296 (17%) Query: 191 NAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEK 250 + I +++ P L++ + LWN + T + ++ H V + Y + Sbjct: 94 HVIPAIQWTPEGRRLVV-ATYSGEFSLWNASSFTFETL---MQAHDSAVTTMKYSHDSDW 149 Query: 251 IMSCGMDHSLKLW--------RINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFST- 301 ++S D +K+W I++ + ++ N +K + +FS Sbjct: 150 MISGDADGMIKIWQPNFSMVKEIDAAHTESIRDMAFSSNDSKFVTCSDDNILKIWNFSNG 209 Query: 302 ------RDIHRNYVDCVRWLGD--LILSKSCENAIVCWKP--GKMEDDIDKIKPSESNVT 351 H + C W + LI S S +N + W P G I K K + Sbjct: 210 KQERVLSGHHWDVKSC-DWHPEMGLIASASKDNLVKLWDPRSGNCISSILKFKHTVLKTR 268 Query: 352 --------ILGRFDYSQCDIWYMRFSMDFW------------------QKMLALGNQVGK 385 ++ C ++ +R+SM + M L G Sbjct: 269 FQPTKGNLLMAISKDKSCRVFDIRYSMKELMCVRDETDYMTLEWHPINESMFTLACYDGS 328 Query: 386 LYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 441 L +DL H KC I S++ I D +I W R R Sbjct: 329 LKHFDLLQNLNEPILTIPYAHDKC---ITSLSYNPVGHIFATAAKDRTIRFWTRAR 381 >5WYJ-BC nrPDB Length = 817 Score = 109 bits (271), Expect = 3e-24, Method: Composition-based stats. Identities = 52/371 (14%), Positives = 128/371 (34%), Gaps = 58/371 (15%) Query: 72 KWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSN-RVTLYEC---H 127 ++ CK+ + + H+ + V +G P T ++ + + Sbjct: 416 RYNENSCKFD---IYAKYIGHSAAVTAVGLPNIVSKGYPEFLLTASNDLTIKKWIIPKPT 472 Query: 128 SQGEIRLLQS--YVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKH 185 + ++++++ Y +++ + + + + A A +I N + Sbjct: 473 ASMDVQIIKVSEYTRHAHEKDINALSVSPN----DSIFATASYDKTCKIWNLENGELEAT 528 Query: 186 YVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYD 245 H + ++ F D LL + S D +++W++ T +++ +EGH + V + Sbjct: 529 LANHKRGLWDVSFCQYD-KLLATSSGDKTVKIWSLDTFSVMKT---LEGHTNAVQRCSFI 584 Query: 246 LLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIH 305 ++++SCG D +K+W +S + + D H Sbjct: 585 NKQKQLISCGADGLIKIWDCSSGECLKTL----------------------------DGH 616 Query: 306 RN--YVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDI 363 N + GD+I+S + WK D + + E + + Q Sbjct: 617 NNRLWALSTMNDGDMIVSADADGVFQFWK------DCTEQEIEEEQEKAKLQVEQEQSLQ 670 Query: 364 WYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSS 423 YM D+ L + ++++ +A + + + F+ + Sbjct: 671 NYMS-KGDWTNAFLLAMTLDHPMRLFNV----LKRALGESRSRQDTEEGKIEVIFNEELD 725 Query: 424 ILIAVCDDASI 434 I++ +D + Sbjct: 726 QAISILNDEQL 736 Score = 84.6 bits (207), Expect = 9e-17, Method: Composition-based stats. Identities = 58/385 (15%), Positives = 129/385 (33%), Gaps = 46/385 (11%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 140 S K ++ + + Q + ++ + + + + ++ + +R ++ Sbjct: 49 SRKILHKISNEDEQEITALKLTPDGQ----YLTYVSQAQLLKIFHLKTGKVVRSMK---- 100 Query: 141 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP 200 + ++ D++++ LLAV G+ G I +++ + GHG I+ LKF+ Sbjct: 101 ------ISSPSYILDADSTSTLLAVGGTDGSIIVVDIENGYITHSFKGHGGTISSLKFYG 154 Query: 201 RDPN---LLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY----DLLGEK--I 251 + + LL S + +++W++ + H V D D + Sbjct: 155 QLNSKIWLLASGDTNGMVKVWDLVKRKCLHTLQE---HTSAVRGLDIIEVPDNDEPSLNL 211 Query: 252 MSCGMDHSLKLWRINSKRM--------MNAIKESYDYNPNKTNRPFISQKIHFPDFSTRD 303 +S G D + LW N K+ +N ES + + + I F D Sbjct: 212 LSGGRDDIINLWDFNMKKKCKLLKTLPVNQQVESCGFLKDGDGKRIIYTAGGDAIFQLID 271 Query: 304 IHRNYVDCVRWLGDL---------ILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILG 354 V ILS S ++ + ++ + + +K E + + Sbjct: 272 SESGSVLKRTNKPIEELFIIGVLPILSNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVTS 331 Query: 355 RFDYSQCDIWYMRF-SMDFWQKMLALGNQVGKLY-VWDLEVEDPHKAKCTTLTHHKCGAA 412 + I MR+ + + LA + ++ V DL + + Sbjct: 332 SIAGNHGIIADMRYVGPELNKLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHE-DL 390 Query: 413 IRQTSFSRDSSILIAVCDDASIWRW 437 + + D + D + W Sbjct: 391 LNSLDATEDGLWIATASKDNTAIVW 415 Score = 72.7 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 62/358 (17%), Positives = 117/358 (32%), Gaps = 50/358 (13%) Query: 93 NQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAW 152 NQ + F +G +++ G L + S ++ ++ Sbjct: 240 NQQVESCGFLKDG-DGKRIIYTAGGDAIFQLIDSESGSVLKRTNKPIEELFIIGVL---- 294 Query: 153 TYDSNTSHPLLAVAGSRGIIRIINPI--------TMQCIKHYVGHGNAINELKFHPRDPN 204 S+ + + S +++IN T+Q G+ I ++++ + N Sbjct: 295 ---PILSNSQMFLVLSDQTLQLINVEEDLKNDEDTIQVTSSIAGNHGIIADMRYVGPELN 351 Query: 205 LLLSVSKDHALRLW---NIQTDTLVAIF--GGVEGHRDEVLSADYDLLGEKIMSCGMDHS 259 L + +LR+ ++ EGH D + S D G I + D++ Sbjct: 352 KLALATNSPSLRIIPVPDLSGPEASLPLDVEIYEGHEDLLNSLDATEDGLWIATASKDNT 411 Query: 260 LKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLI 319 +WR YN N ++ I T N V + + + Sbjct: 412 AIVWR---------------YNENSCKFDIYAKYIGHSAAVTAVGLPNIVS--KGYPEFL 454 Query: 320 LSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLAL 379 L+ S + I W K +D S T + DI + S + + A Sbjct: 455 LTASNDLTIKKWIIPKPTASMDVQIIKVSEYT----RHAHEKDINALSVSPND--SIFAT 508 Query: 380 GNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 + +W+LE + TL +HK G + SF + +L D ++ W Sbjct: 509 ASYDKTCKIWNLE----NGELEATLANHKRG--LWDVSFCQYDKLLATSSGDKTVKIW 560 >4J0W-A nrPDB Length = 343 Score = 108 bits (268), Expect = 6e-24, Method: Composition-based stats. Identities = 51/339 (15%), Positives = 115/339 (33%), Gaps = 45/339 (13%) Query: 107 EGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCA--WTYDSNTSHPLLA 164 D +F+ + + S ++ ++ + + ++ LA Sbjct: 24 PDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLA 83 Query: 165 VAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDT 224 +I I + Q + + GH +A++ L F R + L S S D ++++WN+ + Sbjct: 84 SGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFR-RGTHQLYSTSHDRSVKVWNVAEN- 141 Query: 225 LVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNK 284 + + GH+D V + D + + G D ++++W+I Sbjct: 142 --SYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKI------------------- 180 Query: 285 TNRPFISQKIHFPDFSTRDIHRNYVDCVRW-LGDLILSKSCENAIVCWKPGKMEDDIDKI 343 P SQ + + H+ +DC+ + ++S + + ++ W K + Sbjct: 181 ---PEESQLVFY-------GHQGSIDCIHLINEEHMVSGADDGSVALWGLSK-----KRP 225 Query: 344 KPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTT 403 + L + W + ++A G+ + +W Sbjct: 226 LALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCD 285 Query: 404 LTHHKCGAAIRQTSFSRDSSILIAV-CDDASIWRWDRLR 441 + I FS L+A + + RW R++ Sbjct: 286 IPLV---GFINSLKFSSSGDFLVAGVGQEHRLGRWWRIK 321 Score = 56.1 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 34/244 (13%), Positives = 66/244 (27%), Gaps = 55/244 (22%) Query: 223 DTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNP 282 A + GH+ + I S D S+ W + S R ++ I + Sbjct: 1 GPEAADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAE 60 Query: 283 NKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWKPGKMEDDI 340 K H ++V C+ G + S I+ W+ + + Sbjct: 61 GKP-----------------PGHSSHVLCMAISSDGKYLASGDRSKLILIWE-AQSCQHL 102 Query: 341 DKIKPSESNVTILGRFDYS-------------------QCDIWYMRFSMDFWQKMLA--- 378 V+ L + + + D + A Sbjct: 103 YTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSR 162 Query: 379 -----LGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDAS 433 G + G + VW + P +++ H I + +++ DD S Sbjct: 163 ECCVTAGGRDGTVRVWKI----PEESQLVFYGHQGSIDCIHLI----NEEHMVSGADDGS 214 Query: 434 IWRW 437 + W Sbjct: 215 VALW 218 >5OQL-J nrPDB Length = 912 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 46/307 (14%), Positives = 87/307 (28%), Gaps = 70/307 (22%) Query: 62 APGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGD-----------P 110 A G K W+ S+ C H + + V + P Sbjct: 449 ASGSKDNTARLWRVDPANNSYTCYAVFT-GHLESVGAVALPKVVPPANSEAFKNPLDHPP 507 Query: 111 LVFATVGSNRVTLYEC---HSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAG 167 + +R Q +L S D++ + + L A A Sbjct: 508 AFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPNG----KLFASAS 563 Query: 168 SRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLL-------------LSVSKDHA 214 ++I + ++ GH + ++F P + ++ L+ S D Sbjct: 564 QDKTVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKT 623 Query: 215 LRLWNIQTDTLVAIFGGVEGHRDEVLSA---DYDLLGE------KIMSCGMDHSLKLWRI 265 ++LWN+ T + F EGH VL + S G D +K+W Sbjct: 624 IKLWNLSDYTCIRTF---EGHSHNVLKVVWLHISRDDSITKTKVQFASAGADTLVKVWDA 680 Query: 266 NSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCE 325 N+ + D R + V +++ S + Sbjct: 681 NTGETECTLDNHED--------------------------RLWTLAVHSKTNILASAGSD 714 Query: 326 NAIVCWK 332 + + W+ Sbjct: 715 SKVTFWR 721 Score = 83.1 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 46/362 (12%), Positives = 113/362 (31%), Gaps = 55/362 (15%) Query: 111 LVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRG 170 +++ S + +++ + EI Q L+ A + Sbjct: 288 WMYSAGTSGVLRIWDTTTHHEITKKQDAKSEGEAILSAVSL------PERSLILCAQADF 341 Query: 171 IIRIINPIT------------MQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLW 218 + + + ++ + G + I +L + D +++ + +R+ Sbjct: 342 TLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIV 401 Query: 219 NIQTDTLVA----------IFGG----VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 +++ + FG ++GH D V+S D D G I S D++ +LWR Sbjct: 402 SVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLWR 461 Query: 265 INSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSC 324 ++ + + + + + + ++ ++S S Sbjct: 462 VDPANNSYTCYAVFTGHLESVGAVALPKVVPPANSEAFKNPLDH------PPAFLISGSQ 515 Query: 325 ENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVG 384 + + + DI + +T R DI + S + K+ A +Q Sbjct: 516 DRFVQ-------KRDIPRQLQKGGKLTSSLRRLAHDKDINALDISPN--GKLFASASQDK 566 Query: 385 KLYVWDLEVEDPHKAKCTTLTHHKCG--AAIRQTSFSRDS------SILIAVCDDASIWR 436 + +WD+E + A + + +++ D +I Sbjct: 567 TVKIWDVEKLEVQGILRGHKRGVWTVRFAPLNTPVIQGEQGSVSGRGVVLTGSGDKTIKL 626 Query: 437 WD 438 W+ Sbjct: 627 WN 628 Score = 70.0 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 50/383 (13%), Positives = 103/383 (26%), Gaps = 78/383 (20%) Query: 119 NRVTLYEC--HSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIIN 176 R+ +++ + + + N A++ + + L + + Sbjct: 205 GRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHA----LLSGSRDKTMTLWL 260 Query: 177 PITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHR 236 + + + F + + S LR+W+ T + + Sbjct: 261 WRDGIWQGTPMLRHELLESVGFL-NEGKWMYSAGTSGVLRIWDTTTHHEITKKQDAKSEG 319 Query: 237 DEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNP-------------- 282 + +LSA I+ D +L L+R+ S + + E P Sbjct: 320 EAILSAVSLPERSLILCAQADFTLVLYRVPSPADVVSSSEGILLEPFRRISGTHDEILDL 379 Query: 283 ------------------------------NKTNRPFISQKIHFPDFSTRDIHRNYVDC- 311 ++ N S D + H + V Sbjct: 380 TYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAECRSGSYFGHDVALLKGHEDIVMSL 439 Query: 312 -VRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRF-- 368 V W G I S S +N W ++ P+ ++ T F + + Sbjct: 440 DVDWSGHWIASGSKDNTARLW----------RVDPANNSYTCYAVFTGHLESVGAVALPK 489 Query: 369 ------------SMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCT-TLTHHKCGAAIRQ 415 +D L G+Q + D+ + K T +L I Sbjct: 490 VVPPANSEAFKNPLDHPPAFLISGSQDRFVQKRDIPRQLQKGGKLTSSLRRLAHDKDINA 549 Query: 416 TSFSRDSSILIAVCDDASIWRWD 438 S + + + D ++ WD Sbjct: 550 LDISPNGKLFASASQDKTVKIWD 572 Score = 66.5 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 29/278 (10%), Positives = 80/278 (28%), Gaps = 27/278 (9%) Query: 171 IIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV---- 226 + T + + G G I+ L P +L++ S+ +R++++ Sbjct: 42 NAILTELNTGKRLAEIQGDGEPISTLTITPSGSHLIV-CSRSLTMRIYSLAISPDYDSVE 100 Query: 227 -AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKT 285 + + H V+ D + + D ++K+W I + + + Sbjct: 101 PTLVRTTKPHATPVVVLAVDRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALH 160 Query: 286 NRPFI-----SQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDI 340 P +R + D + + + + I + D+ Sbjct: 161 FFEIAVTAESQSSNKKPKKGSRKGQNDDADEIA-SRFRLAWGTQDGRIRIF-------DL 212 Query: 341 DKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAK 400 K + + + + ++ + +S + + ++ L++W + Sbjct: 213 YKRTTTPVYADPKRKKEAHESNVQCIAYSPEQHALLSGSRDKTMTLWLWRDGIWQGTPML 272 Query: 401 CTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 L F + + + + WD Sbjct: 273 RHELLE--------SVGFLNEGKWMYSAGTSGVLRIWD 302 Score = 61.9 bits (148), Expect = 5e-10, Method: Composition-based stats. Identities = 56/404 (13%), Positives = 110/404 (27%), Gaps = 76/404 (18%) Query: 107 EGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTS------- 159 +G+P+ T+ + L C +R+ + D D T T + + Sbjct: 60 DGEPISTLTITPSGSHLIVCSRSLTMRIYSLAISPDYDSVEPTLVRTTKPHATPVVVLAV 119 Query: 160 ---HPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFH--------------PR- 201 LLA + G I+I + I G ++ L F P+ Sbjct: 120 DRTSTLLATGAADGAIKIWDIIGGYVTHTVSGPSVLVSALHFFEIAVTAESQSSNKKPKK 179 Query: 202 --------DPNLLLS------VSKDHALRLWNIQTDTLVAIFGG----VEGHRDEVLSAD 243 D + + S ++D +R++++ T ++ E H V Sbjct: 180 GSRKGQNDDADEIASRFRLAWGTQDGRIRIFDLYKRTTTPVYADPKRKKEAHESNVQCIA 239 Query: 244 YDLLGEKIMSCGMDHSLKLW----------------RINSKRMMNAIKESYDYNPNKTNR 287 Y ++S D ++ LW + S +N K Y + R Sbjct: 240 YSPEQHALLSGSRDKTMTLWLWRDGIWQGTPMLRHELLESVGFLNEGKWMYSAGTSGVLR 299 Query: 288 PFISQKIH-FPDFSTRDIHRNYVDCVRWLG--DLILSKSCENAIVCWKPGKMEDDIDKIK 344 + + H + L LIL + +V ++ D+ Sbjct: 300 IWDTTTHHEITKKQDAKSEGEAILSAVSLPERSLILCAQADFTLVLYRVP-SPADVVSSS 358 Query: 345 PSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQV-GKLYVWDLEVEDPHKAKCTT 403 + D +A ++ + V D + A+C Sbjct: 359 EGILLEPFRRISGTHDEILDLTYILPDQSMMAIATNSEDIRIVSVKDAQAYSEDNAEC-- 416 Query: 404 LTHHKCGAAIRQTSFSRD----------SSILIAVCDDASIWRW 437 + G + D + + D + W Sbjct: 417 RSGSYFGHDVALLKGHEDIVMSLDVDWSGHWIASGSKDNTARLW 460 >5OQL-X nrPDB Length = 630 Score = 105 bits (261), Expect = 4e-23, Method: Composition-based stats. Identities = 49/274 (17%), Positives = 102/274 (37%), Gaps = 30/274 (10%) Query: 157 NTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALR 216 + + G+ + + N ++ IK + H +A+ L F R N L S SKD ++ Sbjct: 255 SQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFR-RGTNQLYSCSKDRTVK 313 Query: 217 LWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGE-KIMSCG-MDHSLKLWRINSKRMMNAI 274 +W++ +A + GH+DE+ D D LG+ + +S G D + + W++ + + Sbjct: 314 VWSLDE---LAYVETLFGHQDEI--LDIDALGQERCVSVGARDRTARYWKVPEESQL-VF 367 Query: 275 KESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL-GDLILSKSCENAIVCWKP 333 + + + T + + + H +D V + D+ ++ S + W Sbjct: 368 RGGGEGGSSNTKKHKLPPGMD----PASAAHEGSMDRVAMIDDDMFVTGSDNGDLALWSI 423 Query: 334 GKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQK------------MLALGN 381 + + + I DYS +I + ++ G+ Sbjct: 424 QRKKPLHVIARAHGLEPPIKLE-DYSADEIPDPSIIPAPQPRGITALRTLPYSDLIFSGS 482 Query: 382 QVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQ 415 G + VW L + K K + G+ + Sbjct: 483 WDGCIRVWRLSED---KRKLEAVGILGVGSETCE 513 Score = 42.6 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 33/251 (13%), Positives = 64/251 (25%), Gaps = 43/251 (17%) Query: 230 GGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD---------- 279 +GH L G+ +++ G D L ++ + + A + D Sbjct: 240 KTYQGHLKAPLVVKASQDGKFVVTGGADKRLVVYNAADLKPIKAFTQHRDAVTGLAFRRG 299 Query: 280 ----YNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDL--ILSKSCENAIVCWKP 333 Y+ +K + T H++ + + LG + + + WK Sbjct: 300 TNQLYSCSKDRTVKVWSLDELAYVETLFGHQDEILDIDALGQERCVSVGARDRTARYWKV 359 Query: 334 GKMEDDI--DKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQ----KMLALGNQVGKLY 387 + + + SN SMD M G+ G L Sbjct: 360 PEESQLVFRGGGEGGSSNTKKHKLPPGMDPASAAHEGSMDRVAMIDDDMFVTGSDNGDLA 419 Query: 388 VWDLEVEDPHKAKCTTLT-------HHKCGA--------------AIRQTSFSRDSSILI 426 +W ++ + P I S ++ Sbjct: 420 LWSIQRKKPLHVIARAHGLEPPIKLEDYSADEIPDPSIIPAPQPRGITALRTLPYSDLIF 479 Query: 427 AVCDDASIWRW 437 + D I W Sbjct: 480 SGSWDGCIRVW 490 >5WYK-BB nrPDB Length = 943 Score = 104 bits (258), Expect = 8e-23, Method: Composition-based stats. Identities = 46/292 (15%), Positives = 105/292 (35%), Gaps = 57/292 (19%) Query: 74 KSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIR 133 K+ KC +F+C +L +F G LV + + L++ S + Sbjct: 420 KTHKCIRTFECGYAL---------TCKFLP----GGLLVILGTRNGELQLFDLASSSLLD 466 Query: 134 LLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINP---------ITMQCIK 184 ++ DA W+ D + L + ++ + + + Sbjct: 467 TIEDAHDAAI--------WSLDLTSDGKRLVTGSADKTVKFWDFKVENSLVPGTKNKFLP 518 Query: 185 HYVGH-------GNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRD 237 H + I ++ P D L +S+ D+ ++++ + + + + + GH+ Sbjct: 519 VLKLHHDTTLELTDDILCVRVSPDDRYLAISL-LDNTVKVFFLDS---MKFYLSLYGHKL 574 Query: 238 EVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD------YNPNKTNRPFIS 291 VLS D + I++ D ++K+W ++ ++ D + P N S Sbjct: 575 PVLSIDISFDSKMIITSSADKNIKIWGLDFGDCHKSLFAHQDSIMNVKFLPQSHNFFSCS 634 Query: 292 QK--IHFPD------FSTRDIHRN--YVDCVRWLGDLILSKSCENAIVCWKP 333 + + + D H++ + V G ++S S +++I W+ Sbjct: 635 KDAVVKYWDGEKFECIQKLYAHQSEVWALAVATDGGFVVSSSHDHSIRIWEE 686 Score = 95.8 bits (236), Expect = 4e-20, Method: Composition-based stats. Identities = 56/333 (16%), Positives = 115/333 (34%), Gaps = 48/333 (14%) Query: 112 VFATVGSNRVTLYEC----HSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAG 167 + T SN + Y L+++ + T + D + + LLA A Sbjct: 353 LVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQ--RTDVRSIDISDDNKLLATAS 410 Query: 168 SRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVA 227 + G ++I N T +CI+ + KF P L++ +++ L+L+++ + +L+ Sbjct: 411 N-GSLKIWNIKTHKCIRTFE--CGYALTCKFLP-GGLLVILGTRNGELQLFDLASSSLLD 466 Query: 228 IFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNR 287 H + S D G+++++ D ++K W + + P N+ Sbjct: 467 TIED--AHDAAIWSLDLTSDGKRLVTGSADKTVKFWDFKVENSL---------VPGTKNK 515 Query: 288 PFISQKIHFPDFSTRDIHRNYVDCVRWLGD--LILSKSCENAIVCWKPGKMEDDIDKIKP 345 K+H + + CVR D + +N + + Sbjct: 516 FLPVLKLHHDTTLEL---TDDILCVRVSPDDRYLAISLLDNTVKVF-------------- 558 Query: 346 SESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLT 405 ++ + + + S D KM+ + + +W L+ D HK+ Sbjct: 559 FLDSMKFYLSLYGHKLPVLSIDISFDS--KMIITSSADKNIKIWGLDFGDCHKSL----- 611 Query: 406 HHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 +I F S + DA + WD Sbjct: 612 -FAHQDSIMNVKFLPQSHNFFSCSKDAVVKYWD 643 Score = 73.4 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 33/224 (14%), Positives = 72/224 (32%), Gaps = 33/224 (14%) Query: 148 YTCAWTY----DSNTSHPLLAVAGSRGIIRIINPITMQCIKHYV------------GHGN 191 C W +SN S P + + + I + T + Sbjct: 21 ANCVWIPASSGNSNGSGPGQLITSALEDVNIWDIKTGDLVSKLSDGLPPGASDARGAKPA 80 Query: 192 AINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKI 251 L+ H +D +LL D +++W++ + T + GH+ + +D G ++ Sbjct: 81 ECTYLEAH-KDTDLLAVGYADGVIKVWDLMSKT---VLLNFNGHKAAITLLQFDGTGTRL 136 Query: 252 MSCGMDHSLKLWRINSKRMMNAIKESYDYNP-------NKTNRPFISQKIHFPDFSTRD- 303 +S D ++ +W + + + ++ D + I D T Sbjct: 137 ISGSKDSNIIVWDLVGEVGLYKLRSHKDSITGFWCQGEDWLISTSKDGMIKLWDLKTHQC 196 Query: 304 -----IHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDK 342 H + DL+++ ++ + WK D + Sbjct: 197 IETHIAHTGECWGLAVKDDLLITTGTDSQVKIWKLDIENDKMGG 240 Score = 36.1 bits (81), Expect = 0.032, Method: Composition-based stats. Identities = 41/366 (11%), Positives = 98/366 (26%), Gaps = 70/366 (19%) Query: 107 EGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVA 166 +G+ + +T + L++ + I + A D LL Sbjct: 172 QGEDWLISTSKDGMIKLWDLKTHQCIE-----THIAHTGECWGLAVKDD------LLITT 220 Query: 167 GSRGIIRII------NPITMQCI------KHYVGHGNAINELKFHPRDPNLLLSVSKDHA 214 G+ ++I + + + K G I + + + D Sbjct: 221 GTDSQVKIWKLDIENDKMGGKLTEMGIFEKQSKQRGLKIEFITNSSDKTSFFYIQNADKT 280 Query: 215 LRLWNIQTDTLVAI-------FGGVEGHRDEVLSADYDLLGEKIM--------------S 253 + + I+ + +A +G +E ++ + S Sbjct: 281 IETFRIRKEEEIARGLKKREKRLKEKGLTEEEIAKSIKESYSSFILHPFQTIRSLYKIKS 340 Query: 254 CGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVR 313 ++ ++ ++ Y P + P + + + Sbjct: 341 ASW-TTVSSSKLELVLTTSSNTIEYYSIPYEKRDPTSPAPLKTHTIELQGQRTDVRSIDI 399 Query: 314 WLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCD-IWYMRFSMDF 372 + +L+ + ++ W N+ +C +F Sbjct: 400 SDDNKLLATASNGSLKIW-----------------NIKTHKCIRTFECGYALTCKFLP-- 440 Query: 373 WQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDA 432 ++ LG + G+L ++DL AAI + D L+ D Sbjct: 441 GGLLVILGTRNGELQLFDLASSSLLDTI-----EDAHDAAIWSLDLTSDGKRLVTGSADK 495 Query: 433 SIWRWD 438 ++ WD Sbjct: 496 TVKFWD 501 >4GGA-A nrPDB Length = 420 Score = 104 bits (258), Expect = 9e-23, Method: Composition-based stats. Identities = 54/334 (16%), Positives = 108/334 (32%), Gaps = 62/334 (18%) Query: 109 DPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGS 168 V A N V L+ S ++LLQ E + AW + N LAV S Sbjct: 115 SGNVLAVALDNSVYLWSASSGDILQLLQMEQP---GEYISSVAWIKEGN----YLAVGTS 167 Query: 169 RGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAI 228 +++ + + +++ H + L ++ +L S S+ + +++ Sbjct: 168 SAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS---YILSSGSRSGHIHHHDVR--VAEHH 222 Query: 229 FGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRP 288 + GH EV + G + S G D+ + +W P Sbjct: 223 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW------------------------P 258 Query: 289 FISQKIHFPDFSTRDIHRNYVDCVRWLG---DLILSKS--CENAIVCWKPGKMEDDIDKI 343 + + T H+ V V W +++ + + I W Sbjct: 259 SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW------------ 306 Query: 344 KPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTT 403 + + L D + + +S + + + G +L +W + P AK Sbjct: 307 --NVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIW----KYPTMAKVAE 359 Query: 404 LTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 L H + + S D + + + D ++ W Sbjct: 360 LKGHTS--RVLSLTMSPDGATVASAAADETLRLW 391 Score = 74.6 bits (181), Expect = 8e-14, Method: Composition-based stats. Identities = 27/172 (15%), Positives = 52/172 (30%), Gaps = 50/172 (29%) Query: 139 VDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQ----CIKHYVGHGNAIN 194 + + W D LA G+ ++ + + ++ + H A+ Sbjct: 225 TLSGHSQEVCGLRWAPDGRH----LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVK 280 Query: 195 ELKFHPRDPNLLLSVS--KDHALRLWNIQTDTLV-------------------------- 226 + + P N+L + D +R+WN+ + + Sbjct: 281 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHG 340 Query: 227 --------------AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 A ++GH VLS G + S D +L+LWR Sbjct: 341 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 392 Score = 55.3 bits (131), Expect = 5e-08, Method: Composition-based stats. Identities = 34/185 (18%), Positives = 59/185 (31%), Gaps = 36/185 (19%) Query: 40 DAVSIESGTNTERPDTPTNT-PNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFG 98 D + SG N D N P+APG W + +F H + Sbjct: 241 DGRHLASGGN----DNLVNVWPSAPGEGGWVPLQ--------TFT-------QHQGAVKA 281 Query: 99 VQFNWHSKEGDPLVFATVGSNR---VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYD 155 V + V AT G + ++ S + + ++ C+ + Sbjct: 282 VAWCPWQSN----VLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV--------CSILWS 329 Query: 156 SNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHAL 215 + + ++ + I TM + GH + + L P D + S + D L Sbjct: 330 PHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP-DGATVASAAADETL 388 Query: 216 RLWNI 220 RLW Sbjct: 389 RLWRC 393 Score = 31.4 bits (69), Expect = 0.72, Method: Composition-based stats. Identities = 26/196 (13%), Positives = 62/196 (31%), Gaps = 48/196 (24%) Query: 272 NAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCW 331 + +++ Y P+ +R + +I Y++ V W +L+ + +N++ W Sbjct: 80 GSSRKTCRYIPSLPDRILDAPEIRNDY---------YLNLVDWSSGNVLAVALDNSVYLW 130 Query: 332 K----------------PGKMEDDIDKIKPSESNVT--------------ILGRFDYSQC 361 K + T L Sbjct: 131 SASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSA 190 Query: 362 DIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRD 421 + + ++ +L+ G++ G ++ D+ V + H TL+ H + ++ D Sbjct: 191 RVGSLSWNSY----ILSSGSRSGHIHHHDVRVAEHH---VATLSGHSQ--EVCGLRWAPD 241 Query: 422 SSILIAVCDDASIWRW 437 L + +D + W Sbjct: 242 GRHLASGGNDNLVNVW 257 >5G04-R nrPDB Length = 499 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 54/334 (16%), Positives = 108/334 (32%), Gaps = 62/334 (18%) Query: 109 DPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGS 168 V A N V L+ S ++LLQ E + AW + N LAV S Sbjct: 194 SGNVLAVALDNSVYLWSASSGDILQLLQMEQP---GEYISSVAWIKEGN----YLAVGTS 246 Query: 169 RGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAI 228 +++ + + +++ H + L ++ +L S S+ + +++ Sbjct: 247 SAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS---YILSSGSRSGHIHHHDVR--VAEHH 301 Query: 229 FGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRP 288 + GH EV + G + S G D+ + +W P Sbjct: 302 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW------------------------P 337 Query: 289 FISQKIHFPDFSTRDIHRNYVDCVRWLG---DLILSKS--CENAIVCWKPGKMEDDIDKI 343 + + T H+ V V W +++ + + I W Sbjct: 338 SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW------------ 385 Query: 344 KPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTT 403 + + L D + + +S + + + G +L +W + P AK Sbjct: 386 --NVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIW----KYPTMAKVAE 438 Query: 404 LTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 L H + + S D + + + D ++ W Sbjct: 439 LKGHTS--RVLSLTMSPDGATVASAAADETLRLW 470 Score = 74.6 bits (181), Expect = 9e-14, Method: Composition-based stats. Identities = 27/172 (15%), Positives = 52/172 (30%), Gaps = 50/172 (29%) Query: 139 VDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQ----CIKHYVGHGNAIN 194 + + W D LA G+ ++ + + ++ + H A+ Sbjct: 304 TLSGHSQEVCGLRWAPDGRH----LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVK 359 Query: 195 ELKFHPRDPNLLLSVS--KDHALRLWNIQTDTLV-------------------------- 226 + + P N+L + D +R+WN+ + + Sbjct: 360 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHG 419 Query: 227 --------------AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 A ++GH VLS G + S D +L+LWR Sbjct: 420 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 471 Score = 55.3 bits (131), Expect = 5e-08, Method: Composition-based stats. Identities = 33/183 (18%), Positives = 61/183 (33%), Gaps = 32/183 (17%) Query: 40 DAVSIESGTNTERPDTPTNT-PNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFG 98 D + SG N D N P+APG W + +F H + Sbjct: 320 DGRHLASGGN----DNLVNVWPSAPGEGGWVPLQ--------TFT-------QHQGAVKA 360 Query: 99 VQFNWHSKEGDPLVFATVGSNR-VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSN 157 V + + + L S+R + ++ S + + ++ C+ + + Sbjct: 361 VAWCPW--QSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV--------CSILWSPH 410 Query: 158 TSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRL 217 + ++ + I TM + GH + + L P D + S + D LRL Sbjct: 411 YKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP-DGATVASAAADETLRL 469 Query: 218 WNI 220 W Sbjct: 470 WRC 472 Score = 31.4 bits (69), Expect = 0.77, Method: Composition-based stats. Identities = 26/196 (13%), Positives = 62/196 (31%), Gaps = 48/196 (24%) Query: 272 NAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCW 331 + +++ Y P+ +R + +I Y++ V W +L+ + +N++ W Sbjct: 159 GSSRKTCRYIPSLPDRILDAPEIRNDY---------YLNLVDWSSGNVLAVALDNSVYLW 209 Query: 332 K----------------PGKMEDDIDKIKPSESNVT--------------ILGRFDYSQC 361 K + T L Sbjct: 210 SASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSA 269 Query: 362 DIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRD 421 + + ++ +L+ G++ G ++ D+ V + H TL+ H + ++ D Sbjct: 270 RVGSLSWNSY----ILSSGSRSGHIHHHDVRVAEHH---VATLSGHSQ--EVCGLRWAPD 320 Query: 422 SSILIAVCDDASIWRW 437 L + +D + W Sbjct: 321 GRHLASGGNDNLVNVW 336 >5LCW-Q nrPDB Length = 374 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 54/334 (16%), Positives = 108/334 (32%), Gaps = 62/334 (18%) Query: 109 DPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGS 168 V A N V L+ S ++LLQ E + AW + N LAV S Sbjct: 69 SGNVLAVALDNSVYLWSASSGDILQLLQMEQP---GEYISSVAWIKEGN----YLAVGTS 121 Query: 169 RGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAI 228 +++ + + +++ H + L ++ +L S S+ + +++ Sbjct: 122 SAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS---YILSSGSRSGHIHHHDVR--VAEHH 176 Query: 229 FGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRP 288 + GH EV + G + S G D+ + +W P Sbjct: 177 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW------------------------P 212 Query: 289 FISQKIHFPDFSTRDIHRNYVDCVRWLG---DLILSKS--CENAIVCWKPGKMEDDIDKI 343 + + T H+ V V W +++ + + I W Sbjct: 213 SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW------------ 260 Query: 344 KPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTT 403 + + L D + + +S + + + G +L +W + P AK Sbjct: 261 --NVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIW----KYPTMAKVAE 313 Query: 404 LTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 L H + + S D + + + D ++ W Sbjct: 314 LKGHTS--RVLSLTMSPDGATVASAAADETLRLW 345 Score = 74.2 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 27/172 (15%), Positives = 52/172 (30%), Gaps = 50/172 (29%) Query: 139 VDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQ----CIKHYVGHGNAIN 194 + + W D LA G+ ++ + + ++ + H A+ Sbjct: 179 TLSGHSQEVCGLRWAPDGRH----LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVK 234 Query: 195 ELKFHPRDPNLLLSVS--KDHALRLWNIQTDTLV-------------------------- 226 + + P N+L + D +R+WN+ + + Sbjct: 235 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHG 294 Query: 227 --------------AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 A ++GH VLS G + S D +L+LWR Sbjct: 295 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 346 Score = 55.3 bits (131), Expect = 6e-08, Method: Composition-based stats. Identities = 33/183 (18%), Positives = 61/183 (33%), Gaps = 32/183 (17%) Query: 40 DAVSIESGTNTERPDTPTNT-PNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFG 98 D + SG N D N P+APG W + +F H + Sbjct: 195 DGRHLASGGN----DNLVNVWPSAPGEGGWVPLQ--------TFT-------QHQGAVKA 235 Query: 99 VQFNWHSKEGDPLVFATVGSNR-VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSN 157 V + + + L S+R + ++ S + + ++ C+ + + Sbjct: 236 VAWCPW--QSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQV--------CSILWSPH 285 Query: 158 TSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRL 217 + ++ + I TM + GH + + L P D + S + D LRL Sbjct: 286 YKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSP-DGATVASAAADETLRL 344 Query: 218 WNI 220 W Sbjct: 345 WRC 347 Score = 31.4 bits (69), Expect = 0.82, Method: Composition-based stats. Identities = 26/196 (13%), Positives = 62/196 (31%), Gaps = 48/196 (24%) Query: 272 NAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCW 331 + +++ Y P+ +R + +I Y++ V W +L+ + +N++ W Sbjct: 34 GSSRKTCRYIPSLPDRILDAPEIRNDY---------YLNLVDWSSGNVLAVALDNSVYLW 84 Query: 332 K----------------PGKMEDDIDKIKPSESNVT--------------ILGRFDYSQC 361 K + T L Sbjct: 85 SASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSA 144 Query: 362 DIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRD 421 + + ++ +L+ G++ G ++ D+ V + H TL+ H + ++ D Sbjct: 145 RVGSLSWNSY----ILSSGSRSGHIHHHDVRVAEHH---VATLSGHSQ--EVCGLRWAPD 195 Query: 422 SSILIAVCDDASIWRW 437 L + +D + W Sbjct: 196 GRHLASGGNDNLVNVW 211 >5L9T-R nrPDB Length = 493 Score = 102 bits (253), Expect = 3e-22, Method: Composition-based stats. Identities = 54/335 (16%), Positives = 107/335 (31%), Gaps = 65/335 (19%) Query: 109 DPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGS 168 V + V L+ + RL V+ ++ + W+ N L+AV Sbjct: 197 SLNVLSVGLGTCVYLWSACTSQVTRLCDLSVE---GDSVTSVGWSERGN----LVAVGTH 249 Query: 169 RGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAI 228 +G ++I + + + GH + L ++ L S S+D + +I+T + Sbjct: 250 KGFVQIWDAAAGKKLSMLEGHTARVGALAWN---AEQLSSGSRDRMILQRDIRT-PPLQS 305 Query: 229 FGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRP 288 ++GHR EV + + + S G D+ L +W +S Sbjct: 306 ERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSS--------------------- 344 Query: 289 FISQKIHFPDFSTRDIHRNYVDCVRWLGD---LILSKS--CENAIVCWKPGKMEDDIDKI 343 H V + W L+ S + I W Sbjct: 345 -------LSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFW------------ 385 Query: 344 KPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTT 403 + + + SQ + + +S + + G ++ VW + P + Sbjct: 386 -NTLTGQPLQCIDTGSQ--VCNLAWSKHANELVSTHGYSQNQILVW----KYPSLTQVAK 438 Query: 404 LTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 LT H + + S D ++ D ++ W+ Sbjct: 439 LTGHS--YRVLYLAMSPDGEAIVTGAGDETLRFWN 471 Score = 79.2 bits (193), Expect = 4e-15, Method: Composition-based stats. Identities = 40/227 (17%), Positives = 70/227 (30%), Gaps = 61/227 (26%) Query: 87 SLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRL---LQSYVDADA 143 S+ E H + + +N ++ +R+ L ++ LQ + Sbjct: 265 SMLEGHTARVGALAWNAEQ-------LSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVC 317 Query: 144 DENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDP 203 W+ T H LLA G+ + + N ++ ++ Y H A+ + + P Sbjct: 318 G-----LKWS----TDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQH 368 Query: 204 NLLLSVS--KDHALRLWNIQTDTLVAIFGG------------------------------ 231 LL S D +R WN T + Sbjct: 369 GLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVW 428 Query: 232 ----------VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSK 268 + GH VL GE I++ D +L+ W + SK Sbjct: 429 KYPSLTQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSK 475 >4N14-A nrPDB Length = 314 Score = 102 bits (253), Expect = 4e-22, Method: Composition-based stats. Identities = 54/334 (16%), Positives = 108/334 (32%), Gaps = 62/334 (18%) Query: 109 DPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGS 168 V A N V L+ S ++LLQ E + AW + N LAV S Sbjct: 31 SGNVLAVALDNSVYLWSASSGDILQLLQMEQP---GEYISSVAWIKEGN----YLAVGTS 83 Query: 169 RGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAI 228 +++ + + +++ H + L ++ +L S S+ + +++ Sbjct: 84 SAEVQLWDVQQQKRLRNMTSHSARVGSLSWNS---YILSSGSRSGHIHHHDVR--VAEHH 138 Query: 229 FGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRP 288 + GH EV + G + S G D+ + +W P Sbjct: 139 VATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVW------------------------P 174 Query: 289 FISQKIHFPDFSTRDIHRNYVDCVRWLG---DLILSKS--CENAIVCWKPGKMEDDIDKI 343 + + T H+ V V W +++ + + I W Sbjct: 175 SAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIW------------ 222 Query: 344 KPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTT 403 + + L D + + +S + + + G +L +W + P AK Sbjct: 223 --NVCSGACLSAVDAH-SQVCSILWSPHYKELISGHGFAQNQLVIW----KYPTMAKVAE 275 Query: 404 LTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 L H + + S D + + + D ++ W Sbjct: 276 LKGHTS--RVLSLTMSPDGATVASAAADETLRLW 307 Score = 73.4 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 27/172 (15%), Positives = 52/172 (30%), Gaps = 50/172 (29%) Query: 139 VDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQ----CIKHYVGHGNAIN 194 + + W D LA G+ ++ + + ++ + H A+ Sbjct: 141 TLSGHSQEVCGLRWAPDGRH----LASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVK 196 Query: 195 ELKFHPRDPNLLLSVS--KDHALRLWNIQTDTLV-------------------------- 226 + + P N+L + D +R+WN+ + + Sbjct: 197 AVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHG 256 Query: 227 --------------AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 A ++GH VLS G + S D +L+LWR Sbjct: 257 FAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWR 308 Score = 54.2 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 27/162 (16%), Positives = 54/162 (33%), Gaps = 27/162 (16%) Query: 60 PNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSN 119 P+APG W + +F H + V + + + L S+ Sbjct: 174 PSAPGEGGWVPLQ--------TFT-------QHQGAVKAVAWCPW--QSNVLATGGGTSD 216 Query: 120 R-VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPI 178 R + ++ S + + ++ C+ + + + ++ + I Sbjct: 217 RHIRIWNVCSGACLSAVDAHSQV--------CSILWSPHYKELISGHGFAQNQLVIWKYP 268 Query: 179 TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI 220 TM + GH + + L P D + S + D LRLW Sbjct: 269 TMAKVAELKGHTSRVLSLTMSP-DGATVASAAADETLRLWRC 309 Score = 30.7 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 22/160 (13%), Positives = 50/160 (31%), Gaps = 39/160 (24%) Query: 308 YVDCVRWLGDLILSKSCENAIVCWK----------------PGKMEDDIDKIKPSESNVT 351 Y++ V W +L+ + +N++ W K + T Sbjct: 23 YLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGT 82 Query: 352 --------------ILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPH 397 L + + ++ +L+ G++ G ++ D+ V + H Sbjct: 83 SSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSY----ILSSGSRSGHIHHHDVRVAEHH 138 Query: 398 KAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 TL+ H + ++ D L + +D + W Sbjct: 139 ---VATLSGHSQ--EVCGLRWAPDGRHLASGGNDNLVNVW 173 >2AQ5-A nrPDB Length = 402 Score = 101 bits (251), Expect = 7e-22, Method: Composition-based stats. Identities = 41/283 (14%), Positives = 91/283 (32%), Gaps = 33/283 (11%) Query: 142 DADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM-------QCIKHYVGHGNAIN 194 AW ++ ++A + + + + GH + Sbjct: 79 GHTAPVLDIAWCPHNDN---VIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVG 135 Query: 195 ELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSC 254 + +HP N+LLS D+ + +W++ T V G H D + S D+ G I + Sbjct: 136 IVAWHPTAQNVLLSAGCDNVILVWDVGTGAAVLTLGPDV-HPDTIYSVDWSRDGALICTS 194 Query: 255 GMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW 314 D +++ + + + + P TR +H +V + Sbjct: 195 CRDKRVRV--------------------IEPRKGTVVAEKDRPHEGTRPVHAVFVSEGKI 234 Query: 315 LGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQ 374 L S+ E + W +E+ + + S+ +L FD +I Y+ D Sbjct: 235 LTTGF-SRMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFD-PDTNIVYLCGKGDSSI 292 Query: 375 KMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTS 417 + + ++ L+ + + + + + Sbjct: 293 RYFEITSEAPFLHYLSMFSSKESQRGMGYMPKRGLEVNKCEIA 335 Score = 53.8 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 22/135 (16%), Positives = 44/135 (32%), Gaps = 15/135 (11%) Query: 304 IHRNYVDCVRWLG---DLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ 360 H V + W ++I S S + ++ W+ + +P + + Sbjct: 79 GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVIT-------LEGHT 131 Query: 361 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR 420 + + + Q +L + VWD+ A TL I +SR Sbjct: 132 KRVGIVAWHPT-AQNVLLSAGCDNVILVWDV----GTGAAVLTLGPDVHPDTIYSVDWSR 186 Query: 421 DSSILIAVCDDASIW 435 D +++ C D + Sbjct: 187 DGALICTSCRDKRVR 201 >5OQL-L nrPDB Length = 557 Score = 99.6 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 48/308 (15%), Positives = 101/308 (32%), Gaps = 53/308 (17%) Query: 60 PNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPL-------- 111 P+ P + + W+S FK S N P+ + F + Sbjct: 14 PSGPSPITAEQRYWRS------FKKQKSHTSTANWPISHISFPASLGTTALVSSSLVAAA 67 Query: 112 ----VFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAG 167 +FA RV ++ + ++ + D + D + VAG Sbjct: 68 KTNDLFAVTAGPRVEIFSIRKREPLKTI-----GRFDSEAHCGEIRPDG-----RVLVAG 117 Query: 168 SR-GIIRIINPITM---QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTD 223 G +++ + +K + H + K+ P + L+S S D +RLW++ ++ Sbjct: 118 EDTGRMQVFDVGQGTRAVILKTWHIHKQPVWVTKWSPTELTTLMSCSDDKTVRLWDLPSN 177 Query: 224 TLVAIFGGVEGHRDEVLSADY---DLLGEKIMSCGMDHSLKLWR-------INSKRMMNA 273 +F GH D V + ++S D ++++W + + + + Sbjct: 178 DPTRLFT---GHTDYVRCGAFMPGSANSNLLVSGSYDETVRVWDARAPGGAVMTFKHADP 234 Query: 274 IKESYDYNPNKTNRPFISQKIHFPDFSTRD------IHRNYVDCVRWL--GDLILSKSCE 325 I++ T I D H+ V + G ++S S + Sbjct: 235 IEDVLPLPSGTTLLAASGNAISVLDLVAAKPLRLITNHQKTVTSLSLASQGRRVVSGSLD 294 Query: 326 NAIVCWKP 333 + ++ Sbjct: 295 GHVKVFET 302 Score = 49.9 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 21/128 (16%), Positives = 52/128 (40%), Gaps = 15/128 (11%) Query: 312 VRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMD 371 +R G ++++ + + G+ + IL + + +W ++S Sbjct: 107 IRPDGRVLVAGEDTGRMQVFDVGQGTRAV-----------ILKTWHIHKQPVWVTKWSPT 155 Query: 372 FWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDD 431 +++ + + +WDL DP + + +CGA + S +S++L++ D Sbjct: 156 ELTTLMSCSD-DKTVRLWDLPSNDPTRLFTGHTDYVRCGAFMPG---SANSNLLVSGSYD 211 Query: 432 ASIWRWDR 439 ++ WD Sbjct: 212 ETVRVWDA 219 >5Y1U-A nrPDB Length = 456 Score = 99.2 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 55/270 (20%), Positives = 95/270 (35%), Gaps = 56/270 (20%) Query: 185 HYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI----QTDTLVAIFGGVEGHRDEVL 240 GH L ++P LLS S DH + LW+I + +V GH V Sbjct: 203 RLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVE 262 Query: 241 SADYDLLGEKIM-SCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDF 299 + LL E + S D L +W S N T++P S Sbjct: 263 DVSWHLLHESLFGSVADDQKLMIWDTRS---------------NNTSKPSHSV------- 300 Query: 300 STRDIHRNYVDCVRWLGD---LILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRF 356 D H V+C+ + ++ + S + + W D+ +K L F Sbjct: 301 ---DAHTAEVNCLSFNPYSEFILATGSADKTVALW-------DLRNLKLK------LHSF 344 Query: 357 DYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLE--------VEDPHKAKCTTLTHHK 408 + + +I+ +++S + +LA +L VWDL + H Sbjct: 345 ESHKDEIFQVQWSP-HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGG 403 Query: 409 CGAAIRQTSFSRDSS-ILIAVCDDASIWRW 437 A I S++ + ++ +V +D + W Sbjct: 404 HTAKISDFSWNPNEPWVICSVSEDNIMQVW 433 Score = 95.4 bits (235), Expect = 4e-20, Method: Composition-based stats. Identities = 41/323 (12%), Positives = 107/323 (33%), Gaps = 50/323 (15%) Query: 88 LKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGE-----IRLLQSYVDAD 142 +K +H + ++ + ++ S+ V +++ Sbjct: 150 IKINHEGEVNRARYMPQNPC---IIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRG 206 Query: 143 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIIN----PITMQCIKH---YVGHGNAINE 195 + Y +W + N S LL A I + + P + + + GH + + Sbjct: 207 HQKEGYGLSW--NPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 263 Query: 196 LKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIM-SC 254 + +H +L SV+ D L +W+ +++ V+ H EV ++ E I+ + Sbjct: 264 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 323 Query: 255 GMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW 314 D ++ LW + + ++ + + H++ + V+W Sbjct: 324 SADKTVALWDLRNLKL---------------------------KLHSFESHKDEIFQVQW 356 Query: 315 LG---DLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMD 371 ++ S + + W K+ ++ + +L I ++ + Sbjct: 357 SPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPN 416 Query: 372 FWQKMLALGNQVGKLYVWDLEVE 394 ++ ++ + VW + Sbjct: 417 EPW-VICSVSEDNIMQVWQMAEN 438 >5UZ7-B nrPDB Length = 351 Score = 98.9 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 57/354 (16%), Positives = 113/354 (31%), Gaps = 72/354 (20%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTC 150 H ++ + + S+ L+ + ++ +++ ++ ++ + TC Sbjct: 64 GHLAKIYAMHWGTDSR----LLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVM-----TC 114 Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQ----CIKHYVGHGNAINELKFHPRDPNLL 206 A+ N +A G I I N T + + GH ++ +F D N + Sbjct: 115 AYAPSGN----YVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRF--LDDNQI 168 Query: 207 LSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRIN 266 ++ S D LW+I+T F G H +V+S +S D S KLW + Sbjct: 169 VTSSGDTTCALWDIETGQQTTTFTG---HTGDVMSLSLAPDTRLFVSGACDASAKLWDVR 225 Query: 267 SKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL--GDLILSKSC 324 T H + ++ + + G+ + S Sbjct: 226 EGMCR----------------------------QTFTGHESDINAICFFPNGNAFATGSD 257 Query: 325 ENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVG 384 + + + D + + S N+ C I + FS ++L G Sbjct: 258 DATCRLFD---LRADQELMTYSHDNI---------ICGITSVSFSKS--GRLLLAGYDDF 303 Query: 385 KLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 VWD D + L H + + D + D+ + W+ Sbjct: 304 NCNVWDALKAD----RAGVLAGHD--NRVSCLGVTDDGMAVATGSWDSFLKIWN 351 Score = 75.0 bits (182), Expect = 6e-14, Method: Composition-based stats. Identities = 42/263 (15%), Positives = 82/263 (31%), Gaps = 53/263 (20%) Query: 226 VAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKT 285 + + GH ++ + + ++S D L +W + ++AI + Sbjct: 56 MRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCA 115 Query: 286 NRP--------FISQKIHFPDFSTRD----------IHRNYVDCVRWLGD-LILSKSCEN 326 P + + TR+ H Y+ C R+L D I++ S + Sbjct: 116 YAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDT 175 Query: 327 AIVCW--KPGKMEDDIDKIKPSESNVT--------------------------ILGRFDY 358 W + G+ +++ F Sbjct: 176 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 235 Query: 359 SQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSF 418 + DI + F + A G+ ++DL + + T +H I SF Sbjct: 236 HESDINAICFFPN--GNAFATGSDDATCRLFDLRADQ----ELMTYSHDNIICGITSVSF 289 Query: 419 SRDSSILIAVCDDASIWRWDRLR 441 S+ +L+A DD + WD L+ Sbjct: 290 SKSGRLLLAGYDDFNCNVWDALK 312 >3C9C-A nrPDB Length = 432 Score = 98.1 bits (242), Expect = 8e-21, Method: Composition-based stats. Identities = 38/323 (11%), Positives = 102/323 (31%), Gaps = 50/323 (15%) Query: 88 LKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYEC-----HSQGEIRLLQSYVDAD 142 +K +H + + + + ++ S+ V +++ + Sbjct: 125 IKINHEGEVNRAR---YMPQNACVIATKTPSSDVLVFDYTKHPSKPEPSGECQPDLRLRG 181 Query: 143 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKH-------YVGHGNAINE 195 + Y +W + N L A I + + + GH + + Sbjct: 182 HQKEGYGLSWNPNLNG---YLLSASDDHTICLWDINATPKEHRVIDAKNIFTGHTAVVED 238 Query: 196 LKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIM-SC 254 + +H +L SV+ D L +W+ + + V+ H EV ++ E I+ + Sbjct: 239 VAWHLLHESLFGSVADDQKLMIWDTRNNNTSKPSHTVDAHTAEVNCLSFNPYSEFILATG 298 Query: 255 GMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW 314 D ++ LW + + ++ + + H++ + V+W Sbjct: 299 SADKTVALWDLRNLKL---------------------------KLHSFESHKDEIFQVQW 331 Query: 315 LG---DLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMD 371 ++ S + + W K+ ++ + +L I ++ + Sbjct: 332 SPHNETILASSGTDRRLHVWDLSKIGEEQSTEDAEDGPPELLFIHGGHTAKISDFSWNPN 391 Query: 372 FWQKMLALGNQVGKLYVWDLEVE 394 ++ ++ + VW + Sbjct: 392 EPW-IICSVSEDNIMQVWQMAEN 413 >4YCZ-A nrPDB Length = 876 Score = 98.1 bits (242), Expect = 8e-21, Method: Composition-based stats. Identities = 51/301 (16%), Positives = 89/301 (29%), Gaps = 65/301 (21%) Query: 136 QSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPI--TMQCIKHYVGHGNAI 193 Q ++ D+ + Y LA S I+I T + + GH A+ Sbjct: 10 QVIANSGHDDMIHDAVLDYYG----RRLATCSSDRTIKIFEIEGETQRLTETLKGHDGAV 65 Query: 194 NELKF-HPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL--GEK 250 + + HP+ N+L S D + +W IF H+ V + G Sbjct: 66 WCVSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIF-DFALHKASVNVVSWSPHEAGCL 124 Query: 251 IMSCGMDHSLKL-------WRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRD 303 + D ++ + W + S + P + +S K R Sbjct: 125 LACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIVSSKPGPKSTGNRR 184 Query: 304 ------------------------------IHRNYVDCVRWLG-----DLILSKSCENAI 328 H ++V V W I S S + + Sbjct: 185 FVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQKSYIASASEDRTV 244 Query: 329 VCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYV 388 W D P + N +L FD + +W + +S+ +LA K+ + Sbjct: 245 RIWTS-------DPANPLQWNCKVL-NFDAA---VWRVSWSLS--GNVLAASGGDNKVTL 291 Query: 389 W 389 W Sbjct: 292 W 292 Score = 94.6 bits (233), Expect = 8e-20, Method: Composition-based stats. Identities = 40/266 (15%), Positives = 89/266 (33%), Gaps = 52/266 (19%) Query: 90 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYT 149 + H+ ++ V +W + ++ + +V ++ + R+ A + Sbjct: 59 KGHDGAVWCV--SWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDF---ALHKASVNV 113 Query: 150 CAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKH-YVGHGNAINELKFHP-------- 200 +W+ + + LLA A S G + ++ + HG +N + + P Sbjct: 114 VSWSP--HEAGCLLACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSPGSIV 171 Query: 201 --------RDPNLLLSVSKDHALRLW--NIQTDTLVAIFGGVEGHRDEVLSADYDLL--- 247 ++ D+AL++W + T+T + GH D V + Sbjct: 172 SSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHTDWVRDVAWSPTVLQ 231 Query: 248 GEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRN 307 I S D ++++W S NP + N ++ S Sbjct: 232 KSYIASASEDRTVRIW------------TSDPANPLQWNCKVLNFDAAVWRVS------- 272 Query: 308 YVDCVRWLGDLILSKSCENAIVCWKP 333 + G+++ + +N + WK Sbjct: 273 WSLS----GNVLAASGGDNKVTLWKE 294 Score = 57.2 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 39/262 (14%), Positives = 81/262 (30%), Gaps = 88/262 (33%) Query: 234 GHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI--NSKRMMNAIKESYDYNPNKTNRPFIS 291 GH D + A D G ++ +C D ++K++ I ++R+ +K Sbjct: 16 GHDDMIHDAVLDYYGRRLATCSSDRTIKIFEIEGETQRLTETLK---------------- 59 Query: 292 QKIHFPDFSTRDIHRNYVDCVRW----LGDLILSKSCENAIVCWKP-------------G 334 H V CV W G+++ S + ++ W+ Sbjct: 60 ------------GHDGAVWCVSWAHPKYGNILASAGYDGKVLIWRELNGAWQRIFDFALH 107 Query: 335 KMEDDIDKIKPSES-----------NVTIL---------GRFDYSQCDIWYMRFSM---- 370 K ++ P E+ NV++L F + + ++ Sbjct: 108 KASVNVVSWSPHEAGCLLACASSDGNVSVLEFRDNSWEHSIFHAHGLGVNSVSWAPATSP 167 Query: 371 -----------DFWQKMLALGNQVGKLYVWDLEV-EDPHKAKCTTLTHHKCGAAIRQTSF 418 + G L +W + + +K + LT H +R ++ Sbjct: 168 GSIVSSKPGPKSTGNRRFVTGGSDNALKIWAYDPATNTYKLEREPLTGHT--DWVRDVAW 225 Query: 419 SR---DSSILIAVCDDASIWRW 437 S S + + +D ++ W Sbjct: 226 SPTVLQKSYIASASEDRTVRIW 247 >6EMK-B nrPDB Length = 303 Score = 98.1 bits (242), Expect = 8e-21, Method: Composition-based stats. Identities = 44/317 (13%), Positives = 94/317 (29%), Gaps = 54/317 (17%) Query: 97 FGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGE--IRLLQSYVDADADENFYTCAWTY 154 Q N D + AT G V LY+ + + + + +F Sbjct: 31 SDSQVNRLEITNDKKLLATAGHQNVRLYDIRTTNPNPVASFEGHRGNVTSVSF------- 83 Query: 155 DSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHA 214 + + + G I++ + + ++Y H +NE+ HP L+ S +D Sbjct: 84 --QQDNRWMVTSSEDGTIKVWDVRSPSIPRNYK-HNAPVNEVVIHPNQGELI-SCDRDGN 139 Query: 215 LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAI 274 +R+W++ + + + S G + + + +W + Sbjct: 140 IRIWDLGENQCTHQLTPED--DTSLQSLSMASDGSMLAAANTKGNCYVWE---------M 188 Query: 275 KESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDL--ILSKSCENAIVCWK 332 D + H + H Y+ + D+ + + S ++ W Sbjct: 189 PNHTDAS-------------HLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWS 235 Query: 333 PGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLE 392 + + + D Q +W FS D L + + +WDL Sbjct: 236 I-------------DDDFKLETTLDGHQRWVWDCAFSADSA--YLVTASSDHYVRLWDLS 280 Query: 393 VEDPHKAKCTTLTHHKC 409 + + C Sbjct: 281 TREIVRQYGGHHKGAVC 297 Score = 93.5 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 52/283 (18%), Positives = 98/283 (34%), Gaps = 14/283 (4%) Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221 +L AG IR +T C + + +N L+ D LL + + +RL++I+ Sbjct: 4 ILVSAGYDHTIRFWEALTGVCSRTIQHSDSQVNRLEIT-NDKKLLATAGHQN-VRLYDIR 61 Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN 281 T EGHR V S + +++ D ++K+W + S + K + N Sbjct: 62 TTNPN-PVASFEGHRGNVTSVSFQQDNRWMVTSSEDGTIKVWDVRSPSIPRNYKHNAPVN 120 Query: 282 PNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL------GDLILSKSCENAIVCWKPGK 335 + D + R C L LS + + +++ K Sbjct: 121 EVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDTSLQSLSMASDGSMLAAANTK 180 Query: 336 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED 395 + ++ + + + R + K LA + VW ++ + Sbjct: 181 GNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLSSDVKHLATCSADHTARVWSIDDDF 240 Query: 396 PHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 + TL H+ +FS DS+ L+ D + WD Sbjct: 241 KLET---TLDGHQRWVWDC--AFSADSAYLVTASSDHYVRLWD 278 Score = 90.4 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 32/186 (17%), Positives = 70/186 (37%), Gaps = 21/186 (11%) Query: 92 HNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCA 151 HN P+ V + +G+ + +R GE + D T Sbjct: 115 HNAPVNEVVIHP--NQGEL-----ISCDRDGNIRIWDLGENQCTHQLTPEDD-----TSL 162 Query: 152 WTYDSNTSHPLLAVAGSRGIIRII------NPITMQCIKHYVGHGNAINELKFHPRDPNL 205 + + +LA A ++G + + ++ + + H I + D Sbjct: 163 QSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKFRAHSTYITRILLS-SDVKH 221 Query: 206 LLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI 265 L + S DH R+W+I D + ++GH+ V + +++ DH ++LW + Sbjct: 222 LATCSADHTARVWSIDDDFKLET--TLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDL 279 Query: 266 NSKRMM 271 +++ ++ Sbjct: 280 STREIV 285 Score = 61.9 bits (148), Expect = 5e-10, Method: Composition-based stats. Identities = 29/166 (17%), Positives = 55/166 (33%), Gaps = 14/166 (8%) Query: 83 KCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVG-SNRVTLYECHSQGEIRLLQSYVDA 141 +C + L P S D + A ++E + + L+ Sbjct: 149 QCTHQLT-----PEDDTSLQSLSMASDGSMLAAANTKGNCYVWEMPNHTDASHLKPVTKF 203 Query: 142 DADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPIT-MQCIKHYVGHGNAINELKFHP 200 A + T ++ LA + R+ + + GH + + F Sbjct: 204 RAHSTYIT---RILLSSDVKHLATCSADHTARVWSIDDDFKLETTLDGHQRWVWDCAFS- 259 Query: 201 RDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDL 246 D L++ S DH +RLW++ T +V +G GH + + Sbjct: 260 ADSAYLVTASSDHYVRLWDLSTREIVRQYG---GHHKGAVCVALND 302 >2HES-X nrPDB Length = 330 Score = 97.7 bits (241), Expect = 8e-21, Method: Composition-based stats. Identities = 41/248 (16%), Positives = 79/248 (31%), Gaps = 49/248 (19%) Query: 152 WTYDSNTSHPLLAVAGSRGIIRI----INPITMQCIKHYVGHGNAINELKFHPRDPNLLL 207 W++D S +LA + I++ + T+ + H AI + + P +LL Sbjct: 18 WSFDF--SQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRP-HTSLLA 74 Query: 208 SVSKDHALRLW----NIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLW 263 + S D + +W + + + +EGH +EV + G + +C D S+ +W Sbjct: 75 AGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIW 134 Query: 264 RINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGD--LILS 321 + H V V W L+ S Sbjct: 135 ETDESGEEYECISVLQ------------------------EHSQDVKHVIWHPSEALLAS 170 Query: 322 KSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGN 381 S ++ + W K + + + + + +W F L G+ Sbjct: 171 SSYDDTVRIW------------KDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGS 218 Query: 382 QVGKLYVW 389 + VW Sbjct: 219 DDSTVRVW 226 Score = 95.8 bits (236), Expect = 4e-20, Method: Composition-based stats. Identities = 51/322 (15%), Positives = 102/322 (31%), Gaps = 51/322 (15%) Query: 82 FKCVNSLKE-DHNQPLFGVQFNWHSKEGDPLVFATVGSNR-VTLYECHSQGEIRLLQ--- 136 F ++ L E H + + V + H+ + A + V+++ + R + Sbjct: 46 FTLIDVLDETAHKKAIRSVAWRPHT-----SLLAAGSFDSTVSIWAKEESAD-RTFEMDL 99 Query: 137 SYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINP----ITMQCIKHYVGHGNA 192 + + AW+ D LA + I +CI H Sbjct: 100 LAIIEGHENEVKGVAWSNDGY----YLATCSRDKSVWIWETDESGEEYECISVLQEHSQD 155 Query: 193 INELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGE--K 250 + + +HP + LL S S D +R+W D + GH V S+D+D + Sbjct: 156 VKHVIWHPSEA-LLASSSYDDTVRIWKDYDDDW-ECVAVLNGHEGTVWSSDFDKTEGVFR 213 Query: 251 IMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVD 310 + S D ++++W+ + + D + ++ + Sbjct: 214 LCSGSDDSTVRVWKY--------MGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNGLIA 265 Query: 311 CVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSM 370 V G L + + + + + E NV +++ Sbjct: 266 SVGADGVLAVYEEVDGEWKVFAKRALC-----HGVYEINV---------------VKWLE 305 Query: 371 DFWQKMLALGNQVGKLYVWDLE 392 + +LA G G + W LE Sbjct: 306 LNGKTILATGGDDGIVNFWSLE 327 Score = 46.8 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 24/150 (16%), Positives = 59/150 (39%), Gaps = 17/150 (11%) Query: 82 FKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLY----ECHSQGEIRLLQS 137 ++CV L H ++ F+ EG + + + V ++ + + + ++ Sbjct: 187 WECVAVLN-GHEGTVWSSDFD--KTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEA 243 Query: 138 YVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQ---CIKHYVGHGNA-I 193 + Y AW ++ L+A G+ G++ + + + K + HG I Sbjct: 244 ILPDVHKRQVYNVAWGFNG-----LIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEI 298 Query: 194 NELKFHPRDPNLLL-SVSKDHALRLWNIQT 222 N +K+ + +L + D + W+++ Sbjct: 299 NVVKWLELNGKTILATGGDDGIVNFWSLEK 328 Score = 36.8 bits (83), Expect = 0.020, Method: Composition-based stats. Identities = 19/130 (14%), Positives = 43/130 (33%), Gaps = 21/130 (16%) Query: 314 WLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFD--YSQCDIWYMRFSMD 371 + ++ + S + I + + T++ D + I + + Sbjct: 22 FSQGILATGSTDRKIKL------------VSVKYDDFTLIDVLDETAHKKAIRSVAWRPH 69 Query: 372 FWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLT---HHKCGAAIRQTSFSRDSSILIAV 428 +LA G+ + +W E + L H+ ++ ++S D L Sbjct: 70 T--SLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHE--NEVKGVAWSNDGYYLATC 125 Query: 429 CDDASIWRWD 438 D S+W W+ Sbjct: 126 SRDKSVWIWE 135 >4A11-B nrPDB Length = 408 Score = 97.3 bits (240), Expect = 1e-20, Method: Composition-based stats. Identities = 50/297 (16%), Positives = 105/297 (35%), Gaps = 48/297 (16%) Query: 75 SKKCKYSFKCVNSL----KEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQG 130 S++ Y+ K V S+ + H + VQ+ H + ++ + +++ + Sbjct: 77 SRQSYYTCKAVCSIGRDHPDVHRYSVETVQWYPHD---TGMFTSSSFDKTLKVWDTN--- 130 Query: 131 EIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHG 190 LQ+ + +E Y+ + S T H L+AV +++ + + C GH Sbjct: 131 ---TLQTADVFNFEETVYSHHMSPVS-TKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHR 186 Query: 191 NAINELKFHPRDPNLLLSVSKDHALRLWNIQTDT-LVAIFGGVEG------------HRD 237 I + + PR +L + S D ++LW+++ + + G H Sbjct: 187 QEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANTAHNG 246 Query: 238 EVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFIS------ 291 +V + G +++ G D+ ++LW ++ N K + +S Sbjct: 247 KVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGENTLVNYGKVCNNSKKGLKFTVSCGCSSE 306 Query: 292 -------------QKIHFPDFSTRDIHRNYVDCVRWLGDL--ILSKSCENAIVCWKP 333 + H VDC + + + S S + I+ W P Sbjct: 307 FVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAWVP 363 Score = 80.7 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 40/272 (14%), Positives = 86/272 (31%), Gaps = 60/272 (22%) Query: 189 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIF----------GGVEGHRDE 238 HG IN L P + +LS D + L++++ + + + + HR Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHPDVHRYS 101 Query: 239 VLSADYDLLGE-KIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFP 297 V + + S D +LK+W N+ + + Sbjct: 102 VETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFN---------------------F 140 Query: 298 DFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFD 357 + + H + V +K C A+ P D+ + + Sbjct: 141 EETVYSHHMSPVS----------TKHCLVAVGTRGPKVQLCDLK-------SGSCSHILQ 183 Query: 358 YSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWD----------LEVEDPHKAKCTTLTHH 407 + +I + +S + +LA + ++ +WD L+ + K++ + Sbjct: 184 GHRQEILAVSWSPRYDY-ILATASADSRVKLWDVRRASGCLITLDQHNGKKSQAVESANT 242 Query: 408 KCGAAIRQTSFSRDSSILIAVCDDASIWRWDR 439 + F+ D L+ V D + W+ Sbjct: 243 AHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNS 274 Score = 72.7 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 35/250 (14%), Positives = 87/250 (34%), Gaps = 23/250 (9%) Query: 94 QPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWT 153 +P+ G +G +++ S+R + Y C + + + + T W Sbjct: 52 EPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKA---VCSIGRDHPDVHRYSVETVQWY 108 Query: 154 YDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDP--NLLLSVSK 211 + + +++ + T+Q + + P L+ ++ Sbjct: 109 PH---DTGMFTSSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTKHCLVAVGTR 164 Query: 212 DHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIM-SCGMDHSLKLWRINSKRM 270 ++L ++++ + I ++GHR E+L+ + + I+ + D +KLW + R Sbjct: 165 GPKVQLCDLKSGSCSHI---LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVR--RA 219 Query: 271 MNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVC 330 + +N K+ + H + C G +L+ +N + Sbjct: 220 SGCLITLDQHNGKKSQAVESANTAHNGKVNG--------LCFTSDGLHLLTVGTDNRMRL 271 Query: 331 WKPGKMEDDI 340 W E+ + Sbjct: 272 WNSSNGENTL 281 Score = 48.4 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 33/215 (15%), Positives = 66/215 (30%), Gaps = 46/215 (21%) Query: 235 HRDEVLSADYDL-LGEKIMSCGMDHSLKLWRI--NSKRMMNAIKESYDYNPNKTNRPFIS 291 H + + D + G ++S G D + L+ + +S++ K + Sbjct: 42 HGGGINTLDIEPVEGRYMLSGGSDGVIVLYDLENSSRQSYYTCKAVCSIGRDHP------ 95 Query: 292 QKIHFPDFSTRDIHRNYVDCVRWLGD---LILSKSCENAIVCWKPGKMEDDIDKIKPSES 348 D+HR V+ V+W + S S + + W ++ Sbjct: 96 -----------DVHRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQT---------- 134 Query: 349 NVTILGRFDYSQCDIWYMRFSM-DFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHH 407 + ++ S ++A+G + K+ + DL+ Sbjct: 135 -----ADVFNFEETVYSHHMSPVSTKHCLVAVGTRGPKVQLCDLKSGSCSHILQGHRQE- 188 Query: 408 KCGAAIRQTSFSRDSS-ILIAVCDDASIWRWDRLR 441 I S+S IL D+ + WD R Sbjct: 189 -----ILAVSWSPRYDYILATASADSRVKLWDVRR 218 >5FVM-C nrPDB Length = 303 Score = 96.9 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 55/283 (19%), Positives = 101/283 (35%), Gaps = 14/283 (4%) Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221 +LA AG IR +T C + + +N L+ D L + H +RL++I+ Sbjct: 4 ILASAGYDHTIRFWEALTGVCSRTIQHADSQVNRLEIT-SDKKYLAAAGHLH-VRLYDIR 61 Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN 281 ++ EGH+ V S + ++S D ++K+W + S + K + N Sbjct: 62 SNNPN-PVSSFEGHKGNVTSIAFQQENRWMVSSSEDGTIKVWDVRSPSVQRNYKHNAPVN 120 Query: 282 PNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL------GDLILSKSCENAIVCWKPGK 335 + D + R C L LS + + +++ K Sbjct: 121 EVAIHPNQGELISCDQDGNIRIWDLGENQCTNQLTPEDNTPLQSLSVASDGSMLVAGNNK 180 Query: 336 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED 395 + ++ T+ + + R + K LA + VW++E Sbjct: 181 GNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLSADVKNLATCSADHTARVWNIEDNY 240 Query: 396 PHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 + TL H+ +FS DS+ L+ C D + WD Sbjct: 241 QLET---TLDGHQRWVWDC--AFSADSAYLVTACSDHYVRLWD 278 Score = 88.5 bits (217), Expect = 6e-18, Method: Composition-based stats. Identities = 30/182 (16%), Positives = 67/182 (36%), Gaps = 21/182 (11%) Query: 92 HNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCA 151 HN P+ V + +G+ + ++ GE + D T Sbjct: 115 HNAPVNEVAIHP--NQGEL-----ISCDQDGNIRIWDLGENQCTNQLTPEDN-----TPL 162 Query: 152 WTYDSNTSHPLLAVAGSRGIIRII------NPITMQCIKHYVGHGNAINELKFHPRDPNL 205 + + +L ++G + + T++ + + H I + D Sbjct: 163 QSLSVASDGSMLVAGNNKGNCYVWRMPHHTDASTLEPVTKFKSHTKYITRVLLS-ADVKN 221 Query: 206 LLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI 265 L + S DH R+WNI+ + + ++GH+ V + +++ DH ++LW + Sbjct: 222 LATCSADHTARVWNIEDN--YQLETTLDGHQRWVWDCAFSADSAYLVTACSDHYVRLWDL 279 Query: 266 NS 267 ++ Sbjct: 280 ST 281 Score = 67.7 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 30/166 (18%), Positives = 54/166 (32%), Gaps = 14/166 (8%) Query: 83 KCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD-A 141 +C N L + N PL + + +G LV ++ + L+ Sbjct: 149 QCTNQLTPEDNTPLQSLS---VASDGSMLVAGN-NKGNCYVWRMPHHTDASTLEPVTKFK 204 Query: 142 DADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM-QCIKHYVGHGNAINELKFHP 200 + + LA + R+ N Q GH + + F Sbjct: 205 SHTKYITRVLLS----ADVKNLATCSADHTARVWNIEDNYQLETTLDGHQRWVWDCAFS- 259 Query: 201 RDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDL 246 D L++ DH +RLW++ T +V +G GH + + Sbjct: 260 ADSAYLVTACSDHYVRLWDLSTSEIVRQYG---GHHKGAVCVALND 302 >3JRO-A nrPDB Length = 753 Score = 96.9 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 44/271 (16%), Positives = 90/271 (33%), Gaps = 47/271 (17%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 140 + K +++L H P++ V + H K G L + +V +++ + R Q V Sbjct: 42 THKLIDTLT-GHEGPVWRVDWA-HPKFGTILASCS-YDGKVLIWKEENG---RWSQIAVH 95 Query: 141 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYV--GHGNAINELKF 198 A + + W PLL VA S G + ++ + H +N + Sbjct: 96 AVHSASVNSVQWAPHEY--GPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASW 153 Query: 199 HP------------RDPNLLLSVSKDHALRLWNIQTD-TLVAIFGGVEGHRDEVLSADYD 245 P ++ ++ D+ +++W +D + +EGH D V + Sbjct: 154 APATIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWS 213 Query: 246 LL---GEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTR 302 + S D + +W N + + ++ FPD Sbjct: 214 PTVLLRSYLASVSQDRTCIIW--------------TQDNEQGPWKKTLLKEEKFPDVL-- 257 Query: 303 DIHRNYVDCVRWLGDLILSKSCENAIVCWKP 333 + G+++ +N + WK Sbjct: 258 -----WRASWSLSGNVLALSGGDNKVTLWKE 283 Score = 96.9 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 44/287 (15%), Positives = 85/287 (29%), Gaps = 35/287 (12%) Query: 160 HPLLAVAGSRGIIRIINPI--TMQCIKHYVGHGNAINELKF-HPRDPNLLLSVSKDHALR 216 LA S I+I T + I GH + + + HP+ +L S S D + Sbjct: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 Query: 217 LWNIQTDTLVAIFGGVEGHRDEVLSADYDLL--GEKIMSCGMDHSLKLWRINSKRMMNAI 274 +W + I H V S + G ++ D + + Sbjct: 81 IWKEENGRWSQIAVHAV-HSASVNSVQWAPHEYGPLLLVASSDGKVSV---------VEF 130 Query: 275 KESYDYNPNKTNRPFISQKIHFP---DFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCW 331 KE+ +P + I H + ++ ++ +N + W Sbjct: 131 KENGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKF-----VTGGADNLVKIW 185 Query: 332 KPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQK-MLALGNQVGKLYVWD 390 K + + + + +S + LA +Q +W Sbjct: 186 KYNSDAQ----------TYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW- 234 Query: 391 LEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 + + K T L K + + S+S ++L D + W Sbjct: 235 TQDNEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 47.2 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 30/242 (12%), Positives = 76/242 (31%), Gaps = 52/242 (21%) Query: 234 GHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI--NSKRMMNAIKESY------------- 278 H + + A D G+++ +C D ++K++ + + ++++ + Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 279 -----DYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW----LGDLILSKSCENAIV 329 + + + + + + +H V+ V+W G L+L S + + Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 330 CWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQ-----------KMLA 378 + K + + I D + ++ + + Sbjct: 127 VVE----------FKENGTTSPI--IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFV 174 Query: 379 LGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRD---SSILIAVCDDASIW 435 G + +W + +TL H +R ++S S L +V D + Sbjct: 175 TGGADNLVKIWKYNSDAQTYVLESTLEGHS--DWVRDVAWSPTVLLRSYLASVSQDRTCI 232 Query: 436 RW 437 W Sbjct: 233 IW 234 >5XYI-g nrPDB Length = 335 Score = 96.9 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 43/260 (16%), Positives = 81/260 (31%), Gaps = 51/260 (19%) Query: 182 CIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQT--DTLVAIFGGVEGHRDEV 239 +VGH AI ++ + N L+S S+D + +W + + F + GH V Sbjct: 25 PRATFVGHNAAIESIEID-NEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFV 83 Query: 240 LSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDF 299 +++ D +L+LW ++++ Sbjct: 84 SDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFL------------------------ 119 Query: 300 STRDIHRNYVDCVRWLG--DLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFD 357 H+ V V + I+S +N + W + ++V D Sbjct: 120 ----GHKKDVLGVTFSPCNRRIISVGRDNQVKIWNILGENKAELQCSSWVTSVACAPMAD 175 Query: 358 YSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTS 417 + + +A+G GK+Y+W +E E K H Sbjct: 176 ETSPLV-------------IAVGCWDGKVYIWSIEKE--AKLIKEFKAH---DGRCTSVD 217 Query: 418 FSRDSSILIAVCDDASIWRW 437 F+ D +I D + W Sbjct: 218 FTPDGKWVITGGSDRKVVMW 237 Score = 79.6 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 48/359 (13%), Positives = 110/359 (30%), Gaps = 69/359 (19%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTL-YECHSQGEIRLLQSYVDADADENFYT 149 HN + ++ + + + ++ L ++ + E + Sbjct: 31 GHNAAIESIEI-----DNEHNYLVSASRDKSALVWKLNRTQEQWATPFTRLIGHNHFVSD 85 Query: 150 CAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSV 209 + + D++ L + +R+ + T K ++GH + + F P + ++SV Sbjct: 86 VSLSRDASH----LLTSSWDSTLRLWDLSTRTTKKLFLGHKKDVLGVTFSPCN-RRIISV 140 Query: 210 SKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY----DLLGEKIMSCG-MDHSLKLWR 264 +D+ +++WNI + + V S D +++ G D + +W Sbjct: 141 GRDNQVKIWNILGENKAELQC-----SSWVTSVACAPMADETSPLVIAVGCWDGKVYIWS 195 Query: 265 INSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSC 324 I K + K H ++ D + G +++ Sbjct: 196 I-----------------EKEAKLIKEFKAHDGRCTSVDFTPD--------GKWVITGGS 230 Query: 325 ENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVG 384 + +V W N F + + Q + G Sbjct: 231 DRKVVMWL--------------TENGAKTISFTAP-SPVHAVAACP--TQAWICAATYEG 273 Query: 385 KLYVWDLEVEDPHKAKCTTLTH----HKCGAAIRQ-TSFSRDSSILIAVCDDASIWRWD 438 + VWD+ + H + +++ D S+L + +D SI W+ Sbjct: 274 -IAVWDIGAKQQIDLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWE 331 Score = 56.1 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 30/229 (13%), Positives = 68/229 (29%), Gaps = 66/229 (28%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYEC--HSQGEIRLLQSYVDADADENFY 148 H + + GV F+ ++ + + N+V ++ ++ E++ Sbjct: 120 GHKKDVLGVTFSPCNRR----IISVGRDNQVKIWNILGENKAELQCSSWVT--------- 166 Query: 149 TCAWTYDSNTSHPLLAVAGS-RGIIRIINPITM-QCIKHYVGHGNAINELKFHPRDPNLL 206 + A ++ + PL+ G G + I + + IK + H + F P D + Sbjct: 167 SVACAPMADETSPLVIAVGCWDGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFTP-DGKWV 225 Query: 207 LSVSKDHALRLWNIQTDT-----------------------LVAIFGGVE---------- 233 ++ D + +W + A + G+ Sbjct: 226 ITGGSDRKVVMWLTENGAKTISFTAPSPVHAVAACPTQAWICAATYEGIAVWDIGAKQQI 285 Query: 234 ---------------GHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 267 G + + G + S D S++ W + S Sbjct: 286 DLVQPNFKHEGKRNAGRTPDCTCLAWAADGSVLYSGYNDGSIRAWEVKS 334 >3CFV-B nrPDB Length = 414 Score = 94.2 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 42/323 (13%), Positives = 108/323 (33%), Gaps = 50/323 (15%) Query: 88 LKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQG-----EIRLLQSYVDAD 142 +K +H + ++ + ++ S+ V +++ Sbjct: 121 IKINHEGEVNRARYMPQNPH---IIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRG 177 Query: 143 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIIN----PITMQCI---KHYVGHGNAINE 195 + Y +W +SN S LL A + + + P + + + GH + + Sbjct: 178 HQKEGYGLSW--NSNLSGHLL-SASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVED 234 Query: 196 LKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIM-SC 254 + +H +L SV+ D L +W+ +++T V+ H EV ++ E I+ + Sbjct: 235 VAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATG 294 Query: 255 GMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW 314 D ++ LW + + ++ T + H++ + V W Sbjct: 295 SADKTVALWDLRNLKL---------------------------KLHTFESHKDEIFQVHW 327 Query: 315 LG---DLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMD 371 ++ S + + W K+ ++ + +L I ++ + Sbjct: 328 SPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPN 387 Query: 372 FWQKMLALGNQVGKLYVWDLEVE 394 ++ ++ + +W + Sbjct: 388 EPW-VICSVSEDNIMQIWQMAEN 409 >6GMH-W nrPDB Length = 305 Score = 94.2 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 51/314 (16%), Positives = 108/314 (34%), Gaps = 45/314 (14%) Query: 38 NDDAV-SIESGTNT-ERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQP 95 +DDA+ S+ GTN E +T K W KW+ ++ + E H Sbjct: 15 HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVW---KWRDERLDLQWSL-----EGHQLG 66 Query: 96 LFGVQFNWHSKEGDPLVFATVGSN-RVTLYECHSQGEIRLLQSYVDADADENFYTCAWTY 154 + V + + A+ + + L++ + +I+ + + AWT Sbjct: 67 VVSVDISH-----TLPIAASSSLDAHIRLWDLENGKQIKSI---------DAGPVDAWTL 112 Query: 155 DSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHA 214 + LA G + I + + G I + + P D L S + D Sbjct: 113 AFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSP-DGKYLASGAIDGI 171 Query: 215 LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAI 274 + +++I T + +EGH + S + + +++ D +K++ + + + Sbjct: 172 INIFDIATG---KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTL 228 Query: 275 KESYDY--------NPNKTNRPFISQKIHFPDFSTRD------IHRNYVDCVRW--LGDL 318 + + + + D TR H++ V V++ G Sbjct: 229 SGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSK 288 Query: 319 ILSKSCENAIVCWK 332 I+S + I + Sbjct: 289 IVSVGDDQEIHIYD 302 Score = 86.5 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 42/254 (16%), Positives = 83/254 (32%), Gaps = 52/254 (20%) Query: 188 GHGNAINELKF---HPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY 244 H +AI + + + +++ S D +++W + D + + +EGH+ V+S D Sbjct: 14 AHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWR-DERLDLQWSLEGHQLGVVSVDI 72 Query: 245 DLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDI 304 S +D ++LW + + + + +I Sbjct: 73 SHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDA----------------------- 109 Query: 305 HRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIW 364 + + + + + + + D I Sbjct: 110 ---WTLAFSPDSQYLATGTHVGKVNIFG--------------VESGKKEYSLDTRGKFIL 152 Query: 365 YMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSI 424 + +S D K LA G G + ++D+ TL H IR +FS DS + Sbjct: 153 SIAYSPD--GKYLASGAIDGIINIFDI----ATGKLLHTLEGHAM--PIRSLTFSPDSQL 204 Query: 425 LIAVCDDASIWRWD 438 L+ DD I +D Sbjct: 205 LVTASDDGYIKIYD 218 Score = 79.2 bits (193), Expect = 3e-15, Method: Composition-based stats. Identities = 41/298 (13%), Positives = 96/298 (32%), Gaps = 54/298 (18%) Query: 143 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQ--CIKHYVGHGNAINELKFHP 200 D+ ++ AW + + + ++++ + GH + + Sbjct: 15 HDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISH 74 Query: 201 RDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSL 260 P + S S D +RLW+++ + G D + + + + + + Sbjct: 75 TLP-IAASSSLDAHIRLWDLENGKQIKSIDA--GPVDA-WTLAFSPDSQYLATGTHVGKV 130 Query: 261 KLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLIL 320 ++ + S + ++ T FI + PD G + Sbjct: 131 NIFGVESGKKEYSL---------DTRGKFILSIAYSPD-----------------GKYLA 164 Query: 321 SKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALG 380 S + + I + + +L + I + FS D ++L Sbjct: 165 SGAIDGIINIFD--------------IATGKLLHTLEGHAMPIRSLTFSPDS--QLLVTA 208 Query: 381 NQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 + G + ++D++ H TL+ H + +F D + ++ D S+ WD Sbjct: 209 SDDGYIKIYDVQ----HANLAGTLSGHASW--VLNVAFCPDDTHFVSSSSDKSVKVWD 260 Score = 49.5 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 19/140 (13%), Positives = 53/140 (37%), Gaps = 15/140 (10%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 140 + K +++L E H P+ + F+ S+ L+ + +Y+ L + Sbjct: 179 TGKLLHTL-EGHAMPIRSLTFSPDSQ----LLVTASDDGYIKIYDVQHANLAGTLSGHAS 233 Query: 141 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP 200 + F + S +++ + T C+ + H + + +K++ Sbjct: 234 WVLNVAFCP---------DDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYN- 283 Query: 201 RDPNLLLSVSKDHALRLWNI 220 + + ++SV D + +++ Sbjct: 284 GNGSKIVSVGDDQEIHIYDC 303 >6ELZ-p nrPDB Length = 460 Score = 93.8 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 56/299 (18%), Positives = 94/299 (31%), Gaps = 35/299 (11%) Query: 163 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQT 222 + GI+R + ++ K Y GH I +K+ L+S D LRLW + Sbjct: 118 IISGSYDGIVRTWD-LSGNVQKQYSGHSGPIRAVKY--ISNTRLVSAGNDRTLRLWKTKN 174 Query: 223 DTLV--------------------AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKL 262 D L +EGH+ V+S D +I+S D+S+ Sbjct: 175 DDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPVVSIDVS-DNSRILSASYDNSIGF 233 Query: 263 WRINSKRMMNAIKESYDYNPNKTNRPFISQKIHF---PDFSTRDIHRNYVDCVRWLGDLI 319 W K M NPN ++ R + ++ + + Sbjct: 234 WSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTMKDGTIRRRAPLSLLESHTAPVEQV 293 Query: 320 LSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLAL 379 + S +N + G IK + D + + +LA Sbjct: 294 IFDSTDNTV-----GYSVSQDHTIKTWDLVTA--RCIDTRTTSYSLLSIAQLSTLNLLAC 346 Query: 380 GNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 G+ + + D V K L HK + T + IL + D ++ WD Sbjct: 347 GSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTC-PENEYILCSGSHDGTVKVWD 404 Score = 75.0 bits (182), Expect = 6e-14, Method: Composition-based stats. Identities = 44/285 (15%), Positives = 84/285 (29%), Gaps = 82/285 (28%) Query: 90 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYT 149 E H P+ + + +S+ + + N + + E+ ++ D + N + Sbjct: 205 EGHKAPVVSIDVSDNSR-----ILSASYDNSIGFWS-TIYKEMTVVDPLEDINNPNNKIS 258 Query: 150 CAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSV 209 A + G IR + H + ++ F D + SV Sbjct: 259 TAARKRRKLTMK-------DGTIR-----RRAPLSLLESHTAPVEQVIFDSTDNTVGYSV 306 Query: 210 SKDHALRLWNIQTDTLVAIFGG-------------------------------------- 231 S+DH ++ W++ T + Sbjct: 307 SQDHTIKTWDLVTARCIDTRTTSYSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKV 366 Query: 232 ----VEGHRDEVLSADYDLLGEKIM-SCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTN 286 + GH++ V S D E I+ S D ++K+W + S M Sbjct: 367 TQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPMYT------------- 413 Query: 287 RPFISQKIHFPDFSTRDIHRNYVDCVRWLGDL-ILSKSCENAIVC 330 I D S + + V V+W + I+S + I Sbjct: 414 -------ITREDKSVQKGVNDKVFAVKWAEKVGIISAGQDKKIQI 451 Score = 71.5 bits (173), Expect = 8e-13, Method: Composition-based stats. Identities = 38/251 (15%), Positives = 84/251 (33%), Gaps = 39/251 (15%) Query: 190 GNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGE 249 + ++ L ++S S D +R W++ + GH + + Y + Sbjct: 103 EDWVSSLDVG-DGSKHIISGSYDGIVRTWDLSGNVQKQY----SGHSGPIRAVKY-ISNT 156 Query: 250 KIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYV 309 +++S G D +L+LW+ + + ++ + + + + + H+ V Sbjct: 157 RLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAIL-----EGHKAPV 211 Query: 310 DCVRWL-GDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRF 368 + ILS S +N+I W E + +N Sbjct: 212 VSIDVSDNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINN------------------- 252 Query: 369 SMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSF-SRDSSILIA 427 ++ + + + +A + L H + Q F S D+++ + Sbjct: 253 ----PNNKISTAARKRRKLTMK-DGTIRRRAPLSLLESHTA--PVEQVIFDSTDNTVGYS 305 Query: 428 VCDDASIWRWD 438 V D +I WD Sbjct: 306 VSQDHTIKTWD 316 Score = 66.9 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 36/255 (14%), Positives = 68/255 (26%), Gaps = 81/255 (31%) Query: 157 NTSHPLLAVAGSRGIIRII-----------------------NPITMQCIKHYVGHGNAI 193 S+ L AG+ +R+ N + + GH + Sbjct: 152 YISNTRLVSAGNDRTLRLWKTKNDDLKLTSQQQAQEDDDDEVNIEDGKTLAILEGHKAPV 211 Query: 194 NELKFHPRDPNLLLSVSKDHALRLWNI--------------------------------- 220 + D + +LS S D+++ W+ Sbjct: 212 VSIDVS--DNSRILSASYDNSIGFWSTIYKEMTVVDPLEDINNPNNKISTAARKRRKLTM 269 Query: 221 --QTDTLVAIFGGVEGHRDEVLSADYDLLGEKI-MSCGMDHSLKLWRINSKRMMNAIKES 277 T A +E H V +D + S DH++K W + + R ++ S Sbjct: 270 KDGTIRRRAPLSLLESHTAPVEQVIFDSTDNTVGYSVSQDHTIKTWDLVTARCIDTRTTS 329 Query: 278 YDYNPNKTNRPFI---------SQKIHFPDFSTRD--------IHRNYVDCVRWLGD--- 317 Y +H P H+N+V + + Sbjct: 330 YSLLSIAQLSTLNLLACGSSARHITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEY 389 Query: 318 LILSKSCENAIVCWK 332 ++ S S + + W Sbjct: 390 ILCSGSHDGTVKVWD 404 Score = 66.9 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 40/221 (18%), Positives = 79/221 (35%), Gaps = 26/221 (11%) Query: 51 ERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDP 110 E + P N + RK + K K + SL E H P+ V F+ S + Sbjct: 248 EDINNPNNKISTAARK---RRKLTMKDGTIRRRAPLSLLESHTAPVEQVIFD--STDNTV 302 Query: 111 LVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRG 170 + + R + + + + ++ LLA S Sbjct: 303 GYSVSQDHT----IKTWDLVTARCIDTRTTS-------YSLLSIAQLSTLNLLACGSSAR 351 Query: 171 IIRIINPITMQCIK----HYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV 226 I + +P K +GH N ++ L P + +L S S D +++W++++ + + Sbjct: 352 HITLHDPRVGASSKVTQQQLIGHKNFVSSLDTCPENEYILCSGSHDGTVKVWDVRSTSPM 411 Query: 227 AIF-----GGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKL 262 +G D+V + + I+S G D +++ Sbjct: 412 YTITREDKSVQKGVNDKVFAVKW-AEKVGIISAGQDKKIQI 451 >4L9O-A nrPDB Length = 349 Score = 91.9 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 43/291 (14%), Positives = 87/291 (29%), Gaps = 51/291 (17%) Query: 160 HPLLAVAGSRGIIRII--NPITMQCIKHYVGHGNAINELKF-HPRDPNLLLSVSKDHALR 216 LA S I+I + + ++ +GH + ++ + HP+ +L S S D + Sbjct: 81 GRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWAHPKFGVILASCSYDGKVL 140 Query: 217 LWNIQTDTLVAIFGGVEGHRDEVLSADYDLL--GEKIMSCGMDHSLKLWRINSKRMMNAI 274 +W + H+ V S + G ++ D + + Sbjct: 141 IWKEDNGVWNKVAEHSV-HQASVNSVSWAPHEYGPVLLCASSDGKISI------------ 187 Query: 275 KESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLG-------DLILSKSCENA 327 ++ P + Q H V+ W +S C+N Sbjct: 188 ---VEFKDGGALEPIVIQ-----------GHAIGVNAASWAPISLPDNTRRFVSGGCDNL 233 Query: 328 IVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQK-MLALGNQVGKL 386 + W+ F + + +S K +A +Q + Sbjct: 234 VKIWRYDDAAK----------TFIEEEAFQGHSDWVRDVAWSPSRLSKSYIATASQDRTV 283 Query: 387 YVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 +W + +K + LT K + S+S ++L D + W Sbjct: 284 LIW-TKDGKSNKWEKQPLTKEKFPDVCWRASWSLSGNVLAISGGDNKVTLW 333 Score = 44.5 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 30/209 (14%), Positives = 70/209 (33%), Gaps = 43/209 (20%) Query: 234 GHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSK--RMMNAIKESYDYNPNKTNRPFIS 291 H D + A D G ++ +C D ++K++ I+ + R++ + Sbjct: 67 AHDDLIHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEG------------ 114 Query: 292 QKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVT 351 P + H G ++ S S + ++ WK +K+ Sbjct: 115 -----PVWQVAWAHPK-------FGVILASCSYDGKVLIWKEDNGV--WNKVAEHSV--- 157 Query: 352 ILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCG- 410 Q + + ++ + +L + GK+ + +E +D + + H G Sbjct: 158 -------HQASVNSVSWAPHEYGPVLLCASSDGKISI--VEFKDGGALEPIVIQGHAIGV 208 Query: 411 --AAIRQTSFSRDSSILIAVCDDASIWRW 437 A+ S ++ ++ D + W Sbjct: 209 NAASWAPISLPDNTRRFVSGGCDNLVKIW 237 Score = 33.4 bits (74), Expect = 0.23, Method: Composition-based stats. Identities = 12/88 (13%), Positives = 28/88 (31%), Gaps = 7/88 (7%) Query: 90 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIR-LLQSYVDADADENFY 148 + H+ + V ++ AT +R L + Q + + Sbjct: 253 QGHSDWVRDVAWSPSRL--SKSYIATASQDRTVLIWTKDGKSNKWEKQPLTKEKFPDVCW 310 Query: 149 TCAWTYDSNTSHPLLAVAGSRGIIRIIN 176 +W+ N +LA++G + + Sbjct: 311 RASWSLSGN----VLAISGGDNKVTLWK 334 >6BX3-A nrPDB Length = 314 Score = 91.1 bits (224), Expect = 9e-19, Method: Composition-based stats. Identities = 47/295 (15%), Positives = 102/295 (34%), Gaps = 43/295 (14%) Query: 171 IIRIINPITMQCIKHYV-GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIF 229 I I + + V H +EL + P D + + S D ++ + ++ + Sbjct: 34 NILIYDINRRTVSQTLVTSHARPFSELCWSP-DGQCIATASDDFSVEIIHLSYG----LL 88 Query: 230 GGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTN--- 286 GH V+S ++ G + + MD S+K+W + +M I + + Sbjct: 89 HTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMN 148 Query: 287 --------------RPFISQKIHFPDFSTRDIHRNY--------VDCVRWLGD--LILSK 322 R F ++ H T D +++ + V++ + +L K Sbjct: 149 DSSILSSGSYDGLIRIFDAETGHCLKTLTYD--KDWKRENGVVPISQVKFSENARYLLVK 206 Query: 323 SCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQ 382 S + + W + + +L C + ++ D ++ G + Sbjct: 207 SLDGVVKIWDCIGGCV-VRTFQVQPLEKGVLH----HSCGMDFLN-PEDGSTPLVISGYE 260 Query: 383 VGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 G +Y W+ + + + +L HH + + +A+ D +WRW Sbjct: 261 NGDIYCWNSDTKSLLQLLDGSLYHHSS--PVMSIHCFGNIMCSLALNGDCCLWRW 313 Score = 82.7 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 28/193 (14%), Positives = 62/193 (32%), Gaps = 19/193 (9%) Query: 86 NSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADE 145 +L H +P + ++ D AT + S G + + Sbjct: 47 QTLVTSHARPFSELCWSP-----DGQCIATASDDFSVEIIHLSYGLLHTFIGHTAPVISL 101 Query: 146 NFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNL 205 F N LL + I+I + + +K H A+ + D ++ Sbjct: 102 TF---------NRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSVDVPMNDSSI 152 Query: 206 LLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDE-----VLSADYDLLGEKIMSCGMDHSL 260 L S S D +R+++ +T + + + E + + ++ +D + Sbjct: 153 LSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSLDGVV 212 Query: 261 KLWRINSKRMMNA 273 K+W ++ Sbjct: 213 KIWDCIGGCVVRT 225 Score = 51.9 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 34/236 (14%), Positives = 82/236 (34%), Gaps = 59/236 (25%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 140 S+ +++ H P+ + FN L+F + + +++ + ++ + ++ + Sbjct: 84 SYGLLHTF-IGHTAPVISLTFNRKGN----LLFTSSMDESIKIWDTLNGSLMKTISAHSE 138 Query: 141 ADADENFYT------CAWTYDS------------------------------------NT 158 A + + +YD + Sbjct: 139 AVVSVDVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSE 198 Query: 159 SHPLLAVAGSRGIIRIINPITMQCIKHY------VGHGNAINELKF-HPRDPN--LLLSV 209 + L V G+++I + I ++ + G + + F +P D + L++S Sbjct: 199 NARYLLVKSLDGVVKIWDCIGGCVVRTFQVQPLEKGVLHHSCGMDFLNPEDGSTPLVISG 258 Query: 210 SKDHALRLWNIQTDTLVAIF-GGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 ++ + WN T +L+ + G + H V+S G + S ++ LWR Sbjct: 259 YENGDIYCWNSDTKSLLQLLDGSLYHHSSPVMSIHC--FGNIMCSLALNGDCCLWR 312 Score = 37.6 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 22/102 (21%), Positives = 38/102 (37%), Gaps = 15/102 (14%) Query: 339 DIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHK 398 DI++ S++ VT R C +S D + +A + + +E+ Sbjct: 39 DINRRTVSQTLVTSHARPFSELC------WSPD--GQCIATASDD-----FSVEIIHLSY 85 Query: 399 AKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL 440 T H + +F+R ++L D SI WD L Sbjct: 86 GLLHTFIGHTA--PVISLTFNRKGNLLFTSSMDESIKIWDTL 125 >4XFV-A nrPDB Length = 792 Score = 90.8 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 51/374 (13%), Positives = 119/374 (31%), Gaps = 43/374 (11%) Query: 90 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYT 149 + H + V+F + D +V A+ V +++ ++ +Q+ + Sbjct: 60 KGHEAEVTCVRFVP---DSDFMVSASEDH-HVKIWKFTDYSHLQCIQTIQHYSKTIVALS 115 Query: 150 CAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP--------- 200 + L++V + G I I +Q + + H I + F+P Sbjct: 116 ALPS--------LISVGCADGTISIWR-QNIQNDEFGLAHEFTIKKGFFYPLCLSLSKVE 166 Query: 201 RDPNLLLSVSKDHAL-----RLWNIQTDTLVAIFGGVEGHRDEVLSADY----DLLGEKI 251 LL + + L + + + +EGH D V S + + Sbjct: 167 EKKYLLAIGGTNVNVFIASFILSDSGIEKC-RVVAELEGHEDWVKSLAFRHQETPGDYLL 225 Query: 252 MSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTR-----DIHR 306 S D ++LWRI +++ +E +N+ + Q H Sbjct: 226 CSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHD 285 Query: 307 NYVDCVRWLGDL--ILSKSCENAIVCWKPGKMEDDID-KIKPSESNVTILGRFDYSQCDI 363 +++ ++W +L+ + + +++ W+P + ++ E + S Sbjct: 286 DWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGF 345 Query: 364 WYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSS 423 W + + G +W + + L + ++S Sbjct: 346 WSCLWFTHERMDFFLTNGKTGSWRMWATKDNIICDQR---LGISGATKDVTDIAWSPSGE 402 Query: 424 ILIAVCDDASIWRW 437 L+A D + + Sbjct: 403 YLLATSLDQTTRLF 416 Score = 78.4 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 41/313 (13%), Positives = 87/313 (27%), Gaps = 63/313 (20%) Query: 158 TSHPLLAVAGSRGIIRIINPI---TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHA 214 + G+ I + +PI GH + ++F P D + ++S S+DH Sbjct: 28 HKVKKIVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVP-DSDFMVSASEDHH 86 Query: 215 LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR---------- 264 +++W + + ++ + + L I D ++ +WR Sbjct: 87 VKIWKFTDYSHLQCIQTIQHYSKTI--VALSALPSLISVGCADGTISIWRQNIQNDEFGL 144 Query: 265 --------------------INSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDI 304 + K+ + AI + + S + + Sbjct: 145 AHEFTIKKGFFYPLCLSLSKVEEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAELEG 204 Query: 305 HRNYVDCVRWL-----GDLIL-SKSCENAIVCW---------KPGKMEDDIDKIKPSESN 349 H ++V + + GD +L S S + I W + + + + Sbjct: 205 HEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLWRIRINDLIDDSEEDSKKLTLLSNKQYK 264 Query: 350 VTI----------LGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKA 399 I I +++ Q + A L VW+ + Sbjct: 265 FQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAAT--ADTSLMVWEPDETSGIWV 322 Query: 400 KCTTLTHHKCGAA 412 L A Sbjct: 323 CSLRLGEMSSKGA 335 Score = 74.2 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 38/242 (15%), Positives = 77/242 (31%), Gaps = 40/242 (16%) Query: 206 LLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI 265 +++ + LW+ ++ ++GH EV + + ++S DH +K+W+ Sbjct: 33 IVAFGAGKTIALWDPIEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKF 92 Query: 266 NSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCE 325 + T + + + L LI + Sbjct: 93 TDYSHLQC-------------------------IQTIQHYSKTIVALSALPSLISVGCAD 127 Query: 326 NAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKM-LALGNQVG 384 I W+ D+ TI F Y C + S +K LA+G Sbjct: 128 GTISIWRQNIQNDEF----GLAHEFTIKKGFFYPLC----LSLSKVEEKKYLLAIGGTNV 179 Query: 385 KLYVWDLEVEDPHKAKCTTLTHHKC-GAAIRQTSF----SRDSSILIAVCDDASIWRWDR 439 +++ + D KC + + ++ +F + +L + D I W R Sbjct: 180 NVFIASFILSDSGIEKCRVVAELEGHEDWVKSLAFRHQETPGDYLLCSGSQDRYIRLW-R 238 Query: 440 LR 441 +R Sbjct: 239 IR 240 Score = 63.8 bits (153), Expect = 1e-10, Method: Composition-based stats. Identities = 57/386 (14%), Positives = 121/386 (31%), Gaps = 58/386 (15%) Query: 87 SLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQ----------GEIRLLQ 136 +L H+ + +Q++ E + A + ++E GE+ Sbjct: 279 ALIMGHDDWISSLQWH----ESRLQLLAATADTSLMVWEPDETSGIWVCSLRLGEMSSKG 334 Query: 137 SYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQ-CIKHY--VGHGNAI 193 + + F++C W ++ G G R+ C + G + Sbjct: 335 ASTATGSSGGFWSCLWF--THERMDFFLTNGKTGSWRMWATKDNIICDQRLGISGATKDV 392 Query: 194 NELKFHPRDPNLLLSVSKDHALRL---W------NIQTDTLVAIFGGVEGHRDEVLSADY 244 ++ + P LL + S D RL W + F + H +++ + Sbjct: 393 TDIAWSPSGEYLLAT-SLDQTTRLFAPWIYDASGRKREIATWHEFSRPQIHGYDMICVE- 450 Query: 245 DLLGEKIMSCGMDHSLKLWRINSK------RMMNAIKESYDYNPNKTNRPFISQKIHFPD 298 + + +S G + L+ + + + + E P+ P + + Sbjct: 451 TVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGE 510 Query: 299 FSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDY 358 + + D+ + + + MED + + + + Sbjct: 511 DDANEDDEEEEGGNKETPDIT------DPLSLLECPPMEDQLQRHLLW----PEVEKLYG 560 Query: 359 SQCDIWYMRFSMDFWQKMLALGN-----QVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAI 413 +I + S D QK++A Q + ++ E K L H I Sbjct: 561 HGFEITCLDISPD--QKLIASACRSNNVQNAVIRIFSTENWLEIKP---ALPFHSL--TI 613 Query: 414 RQTSFSRDSSILIAVCDDASIWRWDR 439 + FS+D L++VC D W+R Sbjct: 614 TRLKFSKDGKFLLSVCRDRKWALWER 639 Score = 58.4 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 42/267 (15%), Positives = 87/267 (32%), Gaps = 46/267 (17%) Query: 183 IKHYVGHGNAINELKFHPRDPNLLLSVSKDH-----ALRLWNIQTDTLVAIFGGVEGHRD 237 ++ GHG I L P D L+ S + + +R+ T+ + I + H Sbjct: 555 VEKLYGHGFEITCLDISP-DQKLIASACRSNNVQNAVIRI--FSTENWLEIKPALPFHSL 611 Query: 238 EVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFP 297 + + G+ ++S D LW +R M + K + I P Sbjct: 612 TITRLKFSKDGKFLLSVCRDRKWALW----ERNMEDNTFELRFKNEKPHTRIIWDADWAP 667 Query: 298 DFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDD---IDKIKPSESNVTILG 354 G++ ++ S + + W+ K D ++ VT + Sbjct: 668 LE---------------FGNVFVTASRDKTVKVWRHQKEPADDYVLEASIKHTKAVTAIS 712 Query: 355 RFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIR 414 D SM + ++++G + G++Y++ + + I Sbjct: 713 IHD-----------SMIREKILISVGLENGEIYLYSYTLG-KFELITQLNEDITPADKIT 760 Query: 415 QTSFS---RDSSI-LIAVCDDASIWRW 437 + +S R+ + L D S + Sbjct: 761 RLRWSHLKRNGKLFLGVGSSDLSTRIY 787 Score = 54.2 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 58/427 (13%), Positives = 121/427 (28%), Gaps = 102/427 (23%) Query: 76 KKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR-VTLYECHS------ 128 +KC+ V + E H + + F GD + + +R + L+ Sbjct: 194 EKCR-----VVAELEGHEDWVKSLAFRHQETPGD-YLLCSGSQDRYIRLWRIRINDLIDD 247 Query: 129 -----------QGEIRLLQSYVDADADENFYTC-----AW--TYDSNTSHPLLAVAGSRG 170 + Q + NF W + + S L A + Sbjct: 248 SEEDSKKLTLLSNKQYKFQIDDELRVGINFEALIMGHDDWISSLQWHESRLQLLAATADT 307 Query: 171 IIRIINP---------------ITMQCIKHYVGHGNAI-NELKFHPRDPNLLLSVSKDHA 214 + + P ++ + G + L F + L+ K + Sbjct: 308 SLMVWEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGS 367 Query: 215 LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAI 274 R+W + + + G+ G +V + GE +++ +D + +L Sbjct: 368 WRMWATKDNIICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRL------------ 415 Query: 275 KESYDYNPNKTNRPFISQKIHFPDFSTR-DIHRNYVDCV-RWLGDLILSKSCENAIVCWK 332 + P + ++I +R IH + CV +S E + + Sbjct: 416 -----FAPWIYDASGRKREIATWHEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFD 470 Query: 333 PGKMEDDI-----------DKIKPSESNVTILGRFDYSQCDIWYMRF---------SMDF 372 K + P + V +LG + + D + D Sbjct: 471 LPKGVAGMLQKFVGIQFEEKSEMPDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDI 530 Query: 373 WQKMLAL-----GNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIA 427 + L +Q+ + +W + L H G I S D ++ + Sbjct: 531 TDPLSLLECPPMEDQLQRHLLW---------PEVEKLYGH--GFEITCLDISPDQKLIAS 579 Query: 428 VCDDASI 434 C ++ Sbjct: 580 ACRSNNV 586 Score = 40.7 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 26/222 (11%), Positives = 60/222 (27%), Gaps = 35/222 (15%) Query: 220 IQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 279 +Q L + GH E+ D + I S S + NA+ + Sbjct: 546 LQRHLLWPEVEKLYGHGFEITCLDISPDQKLIASA----------CRSNNVQNAVIRIFS 595 Query: 280 YNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWKPGKME 337 +P + H + +++ G +LS + W+ + Sbjct: 596 TENWLEIKPALP------------FHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMED 643 Query: 338 DDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPH 397 + + IW ++ + + ++ + VW + E Sbjct: 644 NTFEL---------RFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRHQKEPAD 694 Query: 398 KAKCTTLTHHKCGAAIRQTSFS--RDSSILIAVCDDASIWRW 437 H S R+ ++ ++ I+ + Sbjct: 695 DYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLY 736 Score = 32.6 bits (72), Expect = 0.32, Method: Composition-based stats. Identities = 17/162 (10%), Positives = 50/162 (30%), Gaps = 16/162 (9%) Query: 120 RVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYD--SNTSHPLLAVAGSRGIIRIIN- 176 R + + + + ++ W D + A +++ Sbjct: 630 RDRKWALWERN-MEDNTFELRFKNEKPHTRIIWDADWAPLEFGNVFVTASRDKTVKVWRH 688 Query: 177 ---PITMQCIKHYVGHGNAINELKFHPRDPN--LLLSVS-KDHALRLWN--IQTDTLVAI 228 P ++ + H A+ + H +L+SV ++ + L++ + L+ Sbjct: 689 QKEPADDYVLEASIKHTKAVTAISIHDSMIREKILISVGLENGEIYLYSYTLGKFELITQ 748 Query: 229 FGGVEGHRDEVLSADYD---LLGEKIMS-CGMDHSLKLWRIN 266 D++ + G+ + D S +++ + Sbjct: 749 LNEDITPADKITRLRWSHLKRNGKLFLGVGSSDLSTRIYSLA 790 >3JRP-A nrPDB Length = 379 Score = 90.4 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 39/261 (14%), Positives = 84/261 (32%), Gaps = 46/261 (17%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTC 150 H P++ V +W + ++ + +V +++ + R Q V A + + Sbjct: 53 GHEGPVWRV--DWAHPKFGTILASCSYDGKVLIWKEENG---RWSQIAVHAVHSASVNSV 107 Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYV--GHGNAINELKFHP-------- 200 W PLL VA S G + ++ + H +N + P Sbjct: 108 QWAPHEY--GPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGE 165 Query: 201 ----RDPNLLLSVSKDHALRLWNIQTD-TLVAIFGGVEGHRDEVLSADYDLL---GEKIM 252 ++ ++ D+ +++W +D + +EGH D V + + Sbjct: 166 HNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLA 225 Query: 253 SCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCV 312 S D + +W N + + ++ FPD + Sbjct: 226 SVSQDRTCIIW--------------TQDNEQGPWKKTLLKEEKFPDVL-------WRASW 264 Query: 313 RWLGDLILSKSCENAIVCWKP 333 G+++ +N + WK Sbjct: 265 SLSGNVLALSGGDNKVTLWKE 285 Score = 90.4 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 43/284 (15%), Positives = 83/284 (29%), Gaps = 29/284 (10%) Query: 160 HPLLAVAGSRGIIRIINPI--TMQCIKHYVGHGNAINELKF-HPRDPNLLLSVSKDHALR 216 LA S I+I T + I GH + + + HP+ +L S S D + Sbjct: 23 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 82 Query: 217 LWNIQTDTLVAIFGGVEGHRDEVLSADYDLL--GEKIMSCGMDHSLKLWRINSKRMMNAI 274 +W + I H V S + G ++ D + + + Sbjct: 83 IWKEENGRWSQIAVHAV-HSASVNSVQWAPHEYGPLLLVASSDGKVSV-------VEFKE 134 Query: 275 KESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPG 334 + + ++ P D N R ++ +N + WK Sbjct: 135 NGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESR----KFVTGGADNLVKIWKYN 190 Query: 335 KMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQK-MLALGNQVGKLYVWDLEV 393 + + + + +S + LA +Q +W + Sbjct: 191 SDAQ----------TYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW-TQD 239 Query: 394 EDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 + K T L K + + S+S ++L D + W Sbjct: 240 NEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 283 Score = 43.0 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 30/242 (12%), Positives = 76/242 (31%), Gaps = 52/242 (21%) Query: 234 GHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI--NSKRMMNAIKESY------------- 278 H + + A D G+++ +C D ++K++ + + ++++ + Sbjct: 9 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 68 Query: 279 -----DYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW----LGDLILSKSCENAIV 329 + + + + + + +H V+ V+W G L+L S + + Sbjct: 69 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 128 Query: 330 CWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQ-----------KMLA 378 + K + + I D + ++ + + Sbjct: 129 VVE----------FKENGTTSPI--IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFV 176 Query: 379 LGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRD---SSILIAVCDDASIW 435 G + +W + +TL H +R ++S S L +V D + Sbjct: 177 TGGADNLVKIWKYNSDAQTYVLESTLEGHS--DWVRDVAWSPTVLLRSYLASVSQDRTCI 234 Query: 436 RW 437 W Sbjct: 235 IW 236 >5MWJ-A nrPDB Length = 337 Score = 88.8 bits (218), Expect = 4e-18, Method: Composition-based stats. Identities = 54/294 (18%), Positives = 97/294 (32%), Gaps = 43/294 (14%) Query: 115 TVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRI 174 T G V +++ G + + D +C D T L V G + I Sbjct: 68 TGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCT----LIVGGEASTLSI 123 Query: 175 INPI--TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGV 232 + T + A L P D + S D + +W++ TLV F Sbjct: 124 WDLAAPTPRIKAELTSSAPACYALAISP-DSKVCFSCCSDGNIAVWDLHNQTLVRQFQ-- 180 Query: 233 EGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMM-----NAIKESYDYNPN---- 283 GH D D G K+ + G+D++++ W + R + + S Y P Sbjct: 181 -GHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWL 239 Query: 284 -KTNRPFISQKIHFPDFSTRDIHRNYVDCV-----RWLGDLILSKSCENAIVCWKPGKME 337 + +H +H + CV + G +S +N + W+ Sbjct: 240 AVGMESSNVEVLHVNKPDKYQLHL-HESCVLSLKFAYCGKWFVSTGKDNLLNAWR----- 293 Query: 338 DDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDL 391 P ++ I + S + S+D K + G+ K V+++ Sbjct: 294 ------TPYGAS--IFQSKESS--SVLSCDISVDD--KYIVTGSGDKKATVYEV 335 Score = 60.3 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 30/176 (17%), Positives = 57/176 (32%), Gaps = 19/176 (10%) Query: 107 EGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVA 166 + F+ + +++ H+Q +R Q + D +C D + L Sbjct: 151 PDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDG------ASCI---DISNDGTKLWTG 201 Query: 167 GSRGIIRIINPITMQCIKHYVGH--GNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDT 224 G +R + + H + I L + P L + + + ++ Sbjct: 202 GLDNTVRSWDLREG---RQLQQHDFTSQIFSLGYCPT-GEWLAVGMESSNVEVLHVNKPD 257 Query: 225 LVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDY 280 + H VLS + G+ +S G D+ L WR + KES Sbjct: 258 KYQ----LHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSV 309 Score = 32.2 bits (71), Expect = 0.45, Method: Composition-based stats. Identities = 23/171 (13%), Positives = 36/171 (21%), Gaps = 18/171 (10%) Query: 270 MMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL-GDLILSKSCENAI 328 P + H V V + + + Sbjct: 15 FHVTADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCV 74 Query: 329 VCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYV 388 W + I + D L +G + L + Sbjct: 75 KVWD--ISHPGNKSPVSQLDCLNR-------DNYIRSCKLLPD--GCTLIVGGEASTLSI 123 Query: 389 WDLEVEDPHKAKCTTLTHHKCGAAIR-QTSFSRDSSILIAVCDDASIWRWD 438 WDL P A + S DS + + C D +I WD Sbjct: 124 WDLAAPTPR-----IKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWD 169 >1NR0-A nrPDB Length = 611 Score = 88.5 bits (217), Expect = 5e-18, Method: Composition-based stats. Identities = 60/358 (16%), Positives = 111/358 (31%), Gaps = 50/358 (13%) Query: 95 PLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTY 154 P+F S + + A VG R G + L + + Sbjct: 100 PVFSGPVKDISWDSESKRIAAVGEGRERF------GHVFLFDTGTSNGNLTGQARAMNSV 153 Query: 155 DSNTSHPL-LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDH 213 D S P + + I + + H ++ ++++P D +L S D Sbjct: 154 DFKPSRPFRIISGSDDNTVAIFEGPPFKFKSTFGEHTKFVHSVRYNP-DGSLFASTGGDG 212 Query: 214 ALRLWNIQTDTLVAIFGG----VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKR 269 + L+N T +F H V + G KI S D ++K+W + + + Sbjct: 213 TIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFGLTWSPDGTKIASASADKTIKIWNVATLK 272 Query: 270 MMNA----------------IKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVR 313 + K++ F++ ++ D R H + + Sbjct: 273 VEKTIPVGTRIEDQQLGIIWTKQALVSISANGFINFVNPELGSID-QVRYGHNKAITALS 331 Query: 314 WL--GDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMD 371 G + S E I W + + +T G S+ D++ + + D Sbjct: 332 SSADGKTLFSADAEGHINSWDISTGISNRVFPDVHATMIT--GIKTTSKGDLFTVSWD-D 388 Query: 372 FWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVC 429 + + A G+ V D KA L+ G + S D I +A C Sbjct: 389 HLKVVPAGGSGV-----------DSSKAVANKLSSQPLG-----LAVSADGDIAVAAC 430 Score = 66.5 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 61/439 (13%), Positives = 121/439 (27%), Gaps = 111/439 (25%) Query: 92 HNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLL--QSYVDADADENFYT 149 H + + V++N L +T G + LY + + S + + + Sbjct: 189 HTKFVHSVRYNPDGS----LFASTGGDGTIVLYNGVDGTKTGVFEDDSLKNVAHSGSVFG 244 Query: 150 CAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYV---------------------- 187 W+ D +A A + I+I N T++ K Sbjct: 245 LTWSPDG----TKIASASADKTIKIWNVATLKVEKTIPVGTRIEDQQLGIIWTKQALVSI 300 Query: 188 ---------------------GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV 226 GH AI L D L S + + W+I T Sbjct: 301 SANGFINFVNPELGSIDQVRYGHNKAITALS-SSADGKTLFSADAEGHINSWDISTGISN 359 Query: 227 AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTN 286 +F V H + G+ + D LK+ +++ K + ++ Sbjct: 360 RVFPDV--HATMITGIKTTSKGDLF-TVSWDDHLKV-VPAGGSGVDSSKAVANKLSSQPL 415 Query: 287 RPFISQKIHFPDFSTRDIHRNYV-------------DCVRWLGDL--ILSKSCENAIVCW 331 +S + Y CV D + ++ + + Sbjct: 416 GLAVSADGDIAVAACYKHIAIYSHGKLTEVPISYNSSCVALSNDKQFVAVGGQDSKVHVY 475 Query: 332 KPGKMEDDIDKIKPSES---------NVTILGRFDYSQCDIWY----------------- 365 K K + N L D S+ I Y Sbjct: 476 KLSGASVSEVKTIVHPAEITSVAFSNNGAFLVATDQSRKVIPYSVANNFELAHTNSWTFH 535 Query: 366 ------MRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFS 419 + +S D + LA G+ + VW++ H + +++ + Sbjct: 536 TAKVACVSWSPDNVR--LATGSLDNSVIVWNMNKPSDHPII---IKGAHAMSSVNSVIWL 590 Query: 420 RDSSILIAVCDDASIWRWD 438 + + +++ D++I W+ Sbjct: 591 -NETTIVSAGQDSNIKFWN 608 Score = 59.6 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 26/182 (14%), Positives = 58/182 (31%), Gaps = 30/182 (16%) Query: 157 NTSHPLLAVAGSRGIIRIINPITMQC--IKHYVGHGNAINELKFHPRDPNLLLSVSKDHA 214 + +AV G + + +K V H I + F + L++ + Sbjct: 457 SNDKQFVAVGGQDSKVHVYKLSGASVSEVKTIV-HPAEITSVAFS-NNGAFLVATDQSRK 514 Query: 215 LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAI 274 + +++ + +A H +V + ++ + +D+S+ +W +N Sbjct: 515 VIPYSVANNFELAHTNSWTFHTAKVACVSWSPDNVRLATGSLDNSVIVWNMNK------- 567 Query: 275 KESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLG-DLILSKSCENAIVCWKP 333 P+ P + V+ V WL I+S ++ I W Sbjct: 568 -------PSDH-----------PIIIKGAHAMSSVNSVIWLNETTIVSAGQDSNIKFWNV 609 Query: 334 GK 335 Sbjct: 610 PF 611 Score = 49.2 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 26/212 (12%), Positives = 63/212 (29%), Gaps = 10/212 (4%) Query: 235 HRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNR--PFISQ 292 H + A G S + ++++W + P K + Sbjct: 58 HSHQTTVAKTSPSGYYCASGDVHGNVRIWDTTQTTHILKTTIPVFSGPVKDISWDSESKR 117 Query: 293 KIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAI-----VCWKPGKMEDDIDKIKPSE 347 + R H D G+L N++ ++ DD Sbjct: 118 IAAVGEGRERFGHVFLFDTGTSNGNLTGQARAMNSVDFKPSRPFRIISGSDDNTVAIFEG 177 Query: 348 SNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWD-LEVEDPHKAKCTTLTH 406 F + +R++ D + A G + +++ ++ + +L + Sbjct: 178 PPFKFKSTFGEHTKFVHSVRYNPD--GSLFASTGGDGTIVLYNGVDGTKTGVFEDDSLKN 235 Query: 407 HKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 ++ ++S D + + + D +I W+ Sbjct: 236 VAHSGSVFGLTWSPDGTKIASASADKTIKIWN 267 >4BZK-B nrPDB Length = 297 Score = 88.5 bits (217), Expect = 5e-18, Method: Composition-based stats. Identities = 39/261 (14%), Positives = 84/261 (32%), Gaps = 46/261 (17%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTC 150 H P++ V +W + ++ + +V +++ + R Q V A + + Sbjct: 51 GHEGPVWRV--DWAHPKFGTILASCSYDGKVLIWKEENG---RWSQIAVHAVHSASVNSV 105 Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYV--GHGNAINELKFHP-------- 200 W PLL VA S G + ++ + H +N + P Sbjct: 106 QWAPHEY--GPLLLVASSDGKVSVVEFKENGTTSPIIIDAHAIGVNSASWAPATIEEDGE 163 Query: 201 ----RDPNLLLSVSKDHALRLWNIQTD-TLVAIFGGVEGHRDEVLSADYDLL---GEKIM 252 ++ ++ D+ +++W +D + +EGH D V + + Sbjct: 164 HNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSPTVLLRSYLA 223 Query: 253 SCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCV 312 S D + +W N + + ++ FPD + Sbjct: 224 SVSQDRTCIIW--------------TQDNEQGPWKKTLLKEEKFPDVL-------WRASW 262 Query: 313 RWLGDLILSKSCENAIVCWKP 333 G+++ +N + WK Sbjct: 263 SLSGNVLALSGGDNKVTLWKE 283 Score = 88.5 bits (217), Expect = 5e-18, Method: Composition-based stats. Identities = 43/284 (15%), Positives = 83/284 (29%), Gaps = 29/284 (10%) Query: 160 HPLLAVAGSRGIIRIINPI--TMQCIKHYVGHGNAINELKF-HPRDPNLLLSVSKDHALR 216 LA S I+I T + I GH + + + HP+ +L S S D + Sbjct: 21 GKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGTILASCSYDGKVL 80 Query: 217 LWNIQTDTLVAIFGGVEGHRDEVLSADYDLL--GEKIMSCGMDHSLKLWRINSKRMMNAI 274 +W + I H V S + G ++ D + + + Sbjct: 81 IWKEENGRWSQIAVHAV-HSASVNSVQWAPHEYGPLLLVASSDGKVSV-------VEFKE 132 Query: 275 KESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPG 334 + + ++ P D N R ++ +N + WK Sbjct: 133 NGTTSPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESR----KFVTGGADNLVKIWKYN 188 Query: 335 KMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQK-MLALGNQVGKLYVWDLEV 393 + + + + +S + LA +Q +W + Sbjct: 189 SDAQ----------TYVLESTLEGHSDWVRDVAWSPTVLLRSYLASVSQDRTCIIW-TQD 237 Query: 394 EDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 + K T L K + + S+S ++L D + W Sbjct: 238 NEQGPWKKTLLKEEKFPDVLWRASWSLSGNVLALSGGDNKVTLW 281 Score = 41.8 bits (96), Expect = 6e-04, Method: Composition-based stats. Identities = 30/242 (12%), Positives = 76/242 (31%), Gaps = 52/242 (21%) Query: 234 GHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI--NSKRMMNAIKESY------------- 278 H + + A D G+++ +C D ++K++ + + ++++ + Sbjct: 7 AHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKF 66 Query: 279 -----DYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW----LGDLILSKSCENAIV 329 + + + + + + +H V+ V+W G L+L S + + Sbjct: 67 GTILASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVS 126 Query: 330 CWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQ-----------KMLA 378 + K + + I D + ++ + + Sbjct: 127 VVE----------FKENGTTSPI--IIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFV 174 Query: 379 LGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRD---SSILIAVCDDASIW 435 G + +W + +TL H +R ++S S L +V D + Sbjct: 175 TGGADNLVKIWKYNSDAQTYVLESTLEGHS--DWVRDVAWSPTVLLRSYLASVSQDRTCI 232 Query: 436 RW 437 W Sbjct: 233 IW 234 >3BG0-A nrPDB Length = 316 Score = 87.3 bits (214), Expect = 1e-17, Method: Composition-based stats. Identities = 45/291 (15%), Positives = 88/291 (30%), Gaps = 39/291 (13%) Query: 160 HPLLAVAGSRGIIRIINPITMQ--CIKHYVGHGNAINELKF-HPRDPNLLLSVSKDHALR 216 LA S ++I + I GH + ++ + HP N+L S S D + Sbjct: 25 GTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84 Query: 217 LWNIQTDTLVAIFGGVEGHRDEVLSADYDLL--GEKIMSCGMDHSLKLWRINSKRMMNAI 274 +W + T GH V S + G + D ++ L + Sbjct: 85 IWREENGTWEK-SHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISL-------LTYTG 136 Query: 275 KESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVR-WLGDLILSKSCENAIVCWKP 333 + ++ + + ++ + S C+N I WK Sbjct: 137 EGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKE 196 Query: 334 -----GKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQK--MLALGNQVGKL 386 K E ++ +V ++ +A +Q G++ Sbjct: 197 EEDGQWKEEQKLEAHSDWVRDVA----------------WAPSIGLPTSTIASCSQDGRV 240 Query: 387 YVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 ++W +D + HK + S+S ++IL D + W Sbjct: 241 FIW--TCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289 Score = 73.8 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 41/266 (15%), Positives = 83/266 (31%), Gaps = 52/266 (19%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTC 150 H P++ Q W ++ + +V ++ + +S+ A D + + Sbjct: 55 GHEGPVW--QVAWAHPMYGNILASCSYDRKVIIWREENGT---WEKSHEHAGHDSSVNSV 109 Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITM---QCIKHYVGHGNAINELKFHP------- 200 W +LA S G I ++ + K H N + + P Sbjct: 110 CWAPHDY--GLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSL 167 Query: 201 ------RDPNLL---LSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL---- 247 + PN + S D+ ++LW + D +E H D V + Sbjct: 168 IDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLP 227 Query: 248 GEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRN 307 I SC D + +W + S ++P ++ F+ H + Sbjct: 228 TSTIASCSQDGRVFIWTCDD-------ASSNTWSPKLLHK-----------FNDVVWHVS 269 Query: 308 YVDCVRWLGDLILSKSCENAIVCWKP 333 + +++ +N + WK Sbjct: 270 W----SITANILAVSGGDNKVTLWKE 291 Score = 29.1 bits (63), Expect = 4.0, Method: Composition-based stats. Identities = 12/87 (13%), Positives = 26/87 (29%), Gaps = 5/87 (5%) Query: 90 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYT 149 E H+ + V + + + RV ++ C + D Sbjct: 209 EAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDV---- 264 Query: 150 CAWTYDSNTSHPLLAVAGSRGIIRIIN 176 W + + +LAV+G + + Sbjct: 265 -VWHVSWSITANILAVSGGDNKVTLWK 290 >5A9Q-2 nrPDB Length = 326 Score = 86.5 bits (212), Expect = 2e-17, Method: Composition-based stats. Identities = 36/213 (16%), Positives = 75/213 (35%), Gaps = 25/213 (11%) Query: 75 SKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQ----- 129 S+ Y+ C + V+FN + A G+N V + C Q Sbjct: 6 SRNAAYTVDC--------EDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEAD 57 Query: 130 GEIRLLQSYVDADADENFYTCAWTYDSNTSH----PLLAVAGSRGIIRII--NPITMQCI 183 E ++ AW+ ++ + + IR+ + Sbjct: 58 VEGIQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEY 117 Query: 184 KHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSAD 243 K GH + IN L F P++ + SVS DH R+WN++ G +S Sbjct: 118 KVLEGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLHSPG-----MSVC 172 Query: 244 YDLLGEK-IMSCGMDHSLKLWRINSKRMMNAIK 275 + +M + +++ + + +++ + +++ Sbjct: 173 WHPEETFKLMVAEKNGTIRFYDLLAQQAILSLE 205 >6CHG-A nrPDB Length = 312 Score = 86.1 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 54/313 (17%), Positives = 110/313 (35%), Gaps = 45/313 (14%) Query: 149 TCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLS 208 +C + D L+A+ + ++ + + + +K H IN L + P D + S Sbjct: 18 SCQISPDG----ELIAICQNTDML-VYEISSSKMMKLTTTHKECINCLCWSP-DSKCIAS 71 Query: 209 VSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSK 268 S+D + + T + + GH V+S Y+ G + S MD S+K W + S Sbjct: 72 GSEDFTVEI----THIIYGRIRRLMGHTAPVISICYNNKGNILCSSSMDESIKEWHVLSG 127 Query: 269 RMMNAIKESYDYNPNKTNRPFISQKIHFPD-------FSTRDIH--------RNY----- 308 + + D + F S + F T H +++ Sbjct: 128 TALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDG 187 Query: 309 ---VDCVRWL--GDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDI 363 + V++ G +L KS +N + W+ + + P + L C + Sbjct: 188 VVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRTFLWPHQETKAKLK----YNCGL 243 Query: 364 WYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSS 423 ++ GN G + VW++ K + + + S S D Sbjct: 244 EL--IYPQGKDPLVISGNDSGSMCVWNVY----SKNLVQKIDEKHRNSPLISISASYDKV 297 Query: 424 ILIAVCDDASIWR 436 +++ + +++R Sbjct: 298 ATLSLNGECNLFR 310 Score = 77.3 bits (188), Expect = 1e-14, Method: Composition-based stats. Identities = 23/169 (13%), Positives = 57/169 (33%), Gaps = 20/169 (11%) Query: 113 FATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGII 172 A+ + G IR L + N +L + I Sbjct: 69 IASGSEDFTVEITHIIYGRIRRLMGHTAPVISI---------CYNNKGNILCSSSMDESI 119 Query: 173 RIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGV 232 + + ++ +K H +A+ + D ++L S S D +R+++ ++ + Sbjct: 120 KEWHVLSGTALKTMSAHSDAVVSIDIPKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYD 179 Query: 233 EGHRDE--------VLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNA 273 +D + + + G+ ++ +D+ +KLW ++ Sbjct: 180 ---KDWIAEDGVVPISTVKFSRNGKFLLVKSLDNVVKLWEYTRGTVVRT 225 Score = 59.9 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 36/261 (13%), Positives = 75/261 (28%), Gaps = 53/261 (20%) Query: 185 HYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY 244 G + P D L+ L ++ I + ++ + H++ + + Sbjct: 8 VLPASGKISTSCQISP-DGELIAICQNTDML-VYEISSSKMMKLTTT---HKECINCLCW 62 Query: 245 DLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDI 304 + I S D ++++ I R+ + Sbjct: 63 SPDSKCIASGSEDFTVEITHIIYGRIRRLM-----------------------------G 93 Query: 305 HRNYVDCVRWL--GDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCD 362 H V + + G+++ S S + +I W + T L Sbjct: 94 HTAPVISICYNNKGNILCSSSMDESIKEW--------------HVLSGTALKTMSAHSDA 139 Query: 363 IWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGA--AIRQTSFSR 420 + + F +L+ G+ G + ++D E K I FSR Sbjct: 140 VVSIDI-PKFDSSILSSGSYDGLIRIFDTESGHCLKTLTYDKDWIAEDGVVPISTVKFSR 198 Query: 421 DSSILIAVCDDASIWRWDRLR 441 + L+ D + W+ R Sbjct: 199 NGKFLLVKSLDNVVKLWEYTR 219 Score = 38.0 bits (86), Expect = 0.008, Method: Composition-based stats. Identities = 27/145 (18%), Positives = 46/145 (31%), Gaps = 27/145 (18%) Query: 84 CVNSLKEDHNQ-------PLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLL- 135 C+ +L D + P+ V+F S+ G L+ ++ N V L+E +R Sbjct: 172 CLKTLTYDKDWIAEDGVVPISTVKF---SRNGKFLLVKSLD-NVVKLWEYTRGTVVRTFL 227 Query: 136 --QSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHY-VGHGNA 192 A N PL+ G + + N + ++ H N Sbjct: 228 WPHQETKAKLKYNCGLELIYPQG--KDPLVISGNDSGSMCVWNVYSKNLVQKIDEKHRN- 284 Query: 193 INELKFHPRDPNLLLSVSKDHALRL 217 P + +S S D L Sbjct: 285 ---------SPLISISASYDKVATL 300 >5A31-R nrPDB Length = 386 Score = 85.8 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 52/279 (18%), Positives = 100/279 (35%), Gaps = 49/279 (17%) Query: 159 SHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLW 218 + LAV + G++ I + + +CI+ GH + + L ++ ++L S S+DH + Sbjct: 142 AGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN---NHVLTSGSRDHRILHR 198 Query: 219 NIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESY 278 +++ F +E H EV +++ K+ S G D+ + ++ SK Sbjct: 199 DVRMPDPF--FETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSK---------- 246 Query: 279 DYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMED 338 T D H+ V + W + G Sbjct: 247 ------------------SPILTFDEHKAAVKAMAWSP---------HKRGVLATGGGTA 279 Query: 339 DIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHK 398 D ++K N +I S I M +S + + + + G L +WD DP Sbjct: 280 D-RRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDP-- 336 Query: 399 AKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 L H + + S D + +++ D ++ W Sbjct: 337 --IAILKGHS--FRVLHLTLSNDGTTVVSGAGDETLRYW 371 Score = 63.4 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 38/180 (21%), Positives = 69/180 (38%), Gaps = 21/180 (11%) Query: 90 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRV-TLYECHSQGEIRLLQSYVDADADENFY 148 E H Q + G+++N + A+ G++ V +YE S+ I + A Sbjct: 211 ESHTQEVCGLKWNVADNK-----LASGGNDNVVHVYEGTSKSPILTFDEHKAAVK----- 260 Query: 149 TCAWTYDSNTSHPLLAVAG--SRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLL 206 AW+ +LA G + ++I N T + N + + L+ Sbjct: 261 AMAWSPH---KRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMV-WSKNTNELV 316 Query: 207 LSVSKDH-ALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI 265 S L LW+ + +AI ++GH VL G ++S D +L+ W++ Sbjct: 317 TSHGYSKYNLTLWDCNSMDPIAI---LKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 373 >4BH6-A nrPDB Length = 308 Score = 84.6 bits (207), Expect = 9e-17, Method: Composition-based stats. Identities = 52/279 (18%), Positives = 100/279 (35%), Gaps = 49/279 (17%) Query: 159 SHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLW 218 + LAV + G++ I + + +CI+ GH + + L ++ ++L S S+DH + Sbjct: 73 AGSHLAVGQANGLVEIYDVMKRKCIRTLSGHIDRVACLSWN---NHVLTSGSRDHRILHR 129 Query: 219 NIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESY 278 +++ F +E H EV +++ K+ S G D+ + ++ SK Sbjct: 130 DVRMPDPF--FETIESHTQEVCGLKWNVADNKLASGGNDNVVHVYEGTSK---------- 177 Query: 279 DYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMED 338 T D H+ V + W + G Sbjct: 178 ------------------SPILTFDEHKAAVKAMAWSP---------HKRGVLATGGGTA 210 Query: 339 DIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHK 398 D ++K N +I S I M +S + + + + G L +WD DP Sbjct: 211 D-RRLKIWNVNTSIKMSDIDSGSQICNMVWSKNTNELVTSHGYSKYNLTLWDCNSMDP-- 267 Query: 399 AKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 L H + + S D + +++ D ++ W Sbjct: 268 --IAILKGHS--FRVLHLTLSNDGTTVVSGAGDETLRYW 302 Score = 62.3 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 38/180 (21%), Positives = 69/180 (38%), Gaps = 21/180 (11%) Query: 90 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRV-TLYECHSQGEIRLLQSYVDADADENFY 148 E H Q + G+++N + A+ G++ V +YE S+ I + A Sbjct: 142 ESHTQEVCGLKWNVADNK-----LASGGNDNVVHVYEGTSKSPILTFDEHKAAVK----- 191 Query: 149 TCAWTYDSNTSHPLLAVAG--SRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLL 206 AW+ +LA G + ++I N T + N + + L+ Sbjct: 192 AMAWSPH---KRGVLATGGGTADRRLKIWNVNTSIKMSDIDSGSQICNMV-WSKNTNELV 247 Query: 207 LSVSKDH-ALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRI 265 S L LW+ + +AI ++GH VL G ++S D +L+ W++ Sbjct: 248 TSHGYSKYNLTLWDCNSMDPIAI---LKGHSFRVLHLTLSNDGTTVVSGAGDETLRYWKL 304 >3ODT-A nrPDB Length = 313 Score = 82.7 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 34/198 (17%), Positives = 68/198 (34%), Gaps = 38/198 (19%) Query: 163 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQT 222 + ++ + + H ++ + K N L+ S D ++LW Q Sbjct: 117 VISGSWDKTAKVWK--EGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLW--QN 172 Query: 223 DTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNP 282 D ++ F G+ H D V G I SC D +KL +++ ++ Sbjct: 173 DKVIKTFSGI--HNDVVRHLAVVDDGHFI-SCSNDGLIKLVDMHTGDVLRT--------- 220 Query: 283 NKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDL-ILSKSCENAIVCW--KPGKMEDD 339 + H ++V C++ L + I+S + + W + G ++ Sbjct: 221 -------------------YEGHESFVYCIKLLPNGDIVSCGEDRTVRIWSKENGSLKQV 261 Query: 340 IDKIKPSESNVTILGRFD 357 I S +V + D Sbjct: 262 ITLPAISIWSVDCMSNGD 279 Score = 78.8 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 31/198 (15%), Positives = 75/198 (37%), Gaps = 29/198 (14%) Query: 67 SWGKGK--WKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLY 124 SW K WK Y+ + HN ++ + S+ + L+ Sbjct: 121 SWDKTAKVWKEGSLVYNLQ-------AHNASVWDAKVVSFSENK---FLTASADKTIKLW 170 Query: 125 ECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIK 184 + ++++++ D A D + + G+I++++ T ++ Sbjct: 171 QND-----KVIKTFSGIHNDV-VRHLAVVDDGH-----FISCSNDGLIKLVDMHTGDVLR 219 Query: 185 HYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY 244 Y GH + + +K P ++S +D +R+W+ + +L + + + S D Sbjct: 220 TYEGHESFVYCIKLLPNGD--IVSCGEDRTVRIWSKENGSLKQVI-TLPAIS--IWSVDC 274 Query: 245 DLLGEKIMSCGMDHSLKL 262 G+ I+ D+ +++ Sbjct: 275 MSNGDIIV-GSSDNLVRI 291 Score = 56.5 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 40/253 (15%), Positives = 76/253 (30%), Gaps = 50/253 (19%) Query: 175 INPITM-QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVE 233 I+P T Q GH + ++ D + + SVS+D +RLW+ L + + Sbjct: 2 IDPFTGYQLSATLKGHDQDVRDVVA--VDDSKVASVSRDGTVRLWSKDDQWLGTVVYTGQ 59 Query: 234 GHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQK 293 G + S YD E ++ G D + N + Sbjct: 60 G---FLNSVCYDSEKELLLFGGKDTMI-------------------------NGVPLFAT 91 Query: 294 IHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTIL 353 T H+ V + + +++S S + WK G + ++ S + ++ Sbjct: 92 SGEDPLYTLIGHQGNVCSLSFQDGVVISGSWDKTAKVWKEGSLVYNLQAHNASVWDAKVV 151 Query: 354 GRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVW--DLEVEDPHKAKCTTLTHHKCGA 411 F + + + +W D ++ + H Sbjct: 152 -----------------SFSENKFLTASADKTIKLWQNDKVIKTFSGIHNDVVRHLAVVD 194 Query: 412 AIRQTSFSRDSSI 424 S S D I Sbjct: 195 DGHFISCSNDGLI 207 >5OQL-d nrPDB Length = 446 Score = 82.7 bits (202), Expect = 3e-16, Method: Composition-based stats. Identities = 39/250 (15%), Positives = 89/250 (35%), Gaps = 44/250 (17%) Query: 85 VNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQ--SYVDAD 142 + + +E P + F+ + A+ G + +++ + +Q S+VD Sbjct: 147 IATWQEG--GPYTSLSFHRSANT----FAASSGQGCIRIWDLEHSTAGQAIQWPSFVDTI 200 Query: 143 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRD 202 D F + ++ + I + + T + V H A N + F+P + Sbjct: 201 TDVCFNQVETS--------VIGSVATDRSIILFDLRTNMPVIKTVLHF-ACNRIVFNPME 251 Query: 203 PNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKL 262 L S+DH + +++ + +GH V+ ++ GE+++S D +++L Sbjct: 252 AMNLAVASEDHNIYIFDARNFD--KALNIQKGHVAAVMDVEFSPTGEELVSGSYDRTIRL 309 Query: 263 WRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSK 322 WR ++ S+ ++ R + IL+ Sbjct: 310 WRRDAGH---------------------SRDVYHTKRMQRVFRTMW----TMDSKYILTG 344 Query: 323 SCENAIVCWK 332 S + + W+ Sbjct: 345 SDDGNVRLWR 354 Score = 78.4 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 39/278 (14%), Positives = 85/278 (30%), Gaps = 48/278 (17%) Query: 163 LAVAGSRGIIRIINPITM-QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221 +A G++++ + T + H N + L F + LLS + D ++LW+ Sbjct: 82 IASGSGDGVVKVWDLTTRDEETWRVAAHNNIVKGLTF--TNDKKLLSCATDG-IKLWDPY 138 Query: 222 TDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN 281 S + + +++W + AI Sbjct: 139 ASPSNTTPIATWQEGGPYTSLSFHRSANTFAASSGQGCIRIWDLEHSTAGQAI------- 191 Query: 282 PNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDID 341 + S D + + + V + + +I+ + Sbjct: 192 ------QWPSFVDTITDVCFNQVETSVIGSV----------ATDRSIILFDL-------- 227 Query: 342 KIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKC 401 +N+ ++ + C+ + F+ LA+ ++ +Y++D D KA Sbjct: 228 -----RTNMPVIKTVLHFACN--RIVFNPMEAMN-LAVASEDHNIYIFDARNFD--KALN 277 Query: 402 TTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDR 439 H + FS L++ D +I W R Sbjct: 278 IQKGHVAA---VMDVEFSPTGEELVSGSYDRTIRLWRR 312 >5WLC-LU nrPDB Length = 489 Score = 82.3 bits (201), Expect = 4e-16, Method: Composition-based stats. Identities = 51/334 (15%), Positives = 103/334 (30%), Gaps = 43/334 (12%) Query: 133 RLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNA 192 + + + Y A Y S LA + G+I+ N T + + H Sbjct: 56 KPFVGQLGYGHRDGVYAIAKNYGSLNK---LATGSADGVIKYWNMSTREEFVSFKAHYGL 112 Query: 193 INEL-----KFHPRDP-----NLLLSVSKDHALRLWNIQTDTL--------------VAI 228 + L +FH + P N +LS S D ++LW+I D + Sbjct: 113 VTGLCVTQPRFHDKKPDLKSQNFMLSCSDDKTVKLWSINVDDYSNKNSSDNDSVTNEEGL 172 Query: 229 FGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK----ESYDYNPNK 284 +G D + G + LW +N + ++ + N+ Sbjct: 173 IRTFDG-ESAFQGIDSHRENSTFATGGA--KIHLWDVNRLKPVSDLSWGADNITSLKFNQ 229 Query: 285 TNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIK 344 ++ D+ N + + + + C N + + +D + Sbjct: 230 NETDILASTGSDNSIVLYDLRTNSPTQ-KIVQTMRTNAICWNPMEAFNFVTANEDHNAYY 288 Query: 345 PSESNVTILGR-FDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTT 403 N++ F + + FS + G+ + ++ + T Sbjct: 289 YDMRNLSRSLNVFKDHVSAVMDVDFSP--TGDEIVTGSYDKSIRIYKTNHGHSREIYHTK 346 Query: 404 LTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 H + Q +S DS +I+ DD ++ W Sbjct: 347 RMQH-----VFQVKYSMDSKYIISGSDDGNVRLW 375 Score = 77.7 bits (189), Expect = 9e-15, Method: Composition-based stats. Identities = 32/216 (14%), Positives = 80/216 (37%), Gaps = 19/216 (8%) Query: 94 QPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEI-RLLQSYVDADADENFYTCAW 152 + ++FN + + ++ +T N + LY+ + +++Q+ W Sbjct: 220 DNITSLKFNQNETD---ILASTGSDNSIVLYDLRTNSPTQKIVQTMRTNAI-------CW 269 Query: 153 TYDSNTSHPLLAVAGSRGIIRIINPITM-QCIKHYVGHGNAINELKFHPRDPNLLLSVSK 211 A + + + + + H +A+ ++ F P + +++ S Sbjct: 270 NP---MEAFNFVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPT-GDEIVTGSY 325 Query: 212 DHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMM 271 D ++R++ I+ V Y + + I+S D +++LWR + Sbjct: 326 DKSIRIYKTNHGHSREIYHTKR--MQHVFQVKYSMDSKYIISGSDDGNVRLWRSKAWERS 383 Query: 272 NAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRN 307 N +K + + N + + + H P+ HR+ Sbjct: 384 N-VKTTREKNKLEYDEKLKERFRHMPEIKRISRHRH 418 Score = 67.3 bits (162), Expect = 1e-11, Method: Composition-based stats. Identities = 35/233 (15%), Positives = 75/233 (32%), Gaps = 37/233 (15%) Query: 101 FNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSH 160 F + FAT G+ + L++ + + L D F + Sbjct: 182 FQGIDSHRENSTFATGGAK-IHLWDVNRLKPVSDLSWGADNITSLKF--------NQNET 232 Query: 161 PLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI 220 +LA GS I + + T + V N + ++P + ++ ++DH +++ Sbjct: 233 DILASTGSDNSIVLYDLRTNSPTQKIVQ-TMRTNAICWNPMEAFNFVTANEDHNAYYYDM 291 Query: 221 QTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDY 280 + L + H V+ D+ G++I++ D S+++ Y Sbjct: 292 RN--LSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRI-----------------Y 332 Query: 281 NPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKP 333 N + I + I+S S + + W+ Sbjct: 333 KTNHGHSREIYHTKRMQHVFQVKYSMDS--------KYIISGSDDGNVRLWRS 377 >4U1E-I nrPDB Length = 347 Score = 81.1 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 41/265 (15%), Positives = 88/265 (33%), Gaps = 35/265 (13%) Query: 185 HYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY 244 GH + ++K++ ++ +LL S SKD + +W G ++GH + S D Sbjct: 5 KLTGHERPLTQVKYN-KEGDLLFSCSKDSSASVWYSLNGE---RLGTLDGHTGTIWSIDV 60 Query: 245 DLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE-----SYDYNP---------NKTNRPFI 290 D + ++ D+S+KLW +++ + + K +++P + + Sbjct: 61 DCFTKYCVTGSADYSIKLWDVSNGQCVATWKSPVPVKRVEFSPCGNYFLAILDNVMKNPG 120 Query: 291 SQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKP-------GKMEDDIDKI 343 S I+ + + V + + W G + I K Sbjct: 121 SINIYEIERDSATHELTKVSEEPIHKIITHEGLDAATVAGWSTKGKYIIAGHKDGKISKY 180 Query: 344 KPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTT 403 S N + D + I M+FS D ++ ++ D+ Sbjct: 181 DVSN-NYEYVDSIDLHEKSISDMQFSPDLT--YFITSSRDTNSFLVDVST-------LQV 230 Query: 404 LTHHKCGAAIRQTSFSRDSSILIAV 428 L ++ + + +I Sbjct: 231 LKKYETDCPLNTAVITPLKEFIILG 255 Score = 68.8 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 46/353 (13%), Positives = 111/353 (31%), Gaps = 48/353 (13%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTC 150 H +PL V++N KEGD L + S +++ + + L + Sbjct: 8 GHERPLTQVKYN---KEGDLLFSCSKDS-SASVWYSLNGERLGTLDGHT---------GT 54 Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS 210 W+ D + + I++ + QC+ + + ++F P L Sbjct: 55 IWSIDVDCFTKYCVTGSADYSIKLWDVSNGQCVATWKS-PVPVKRVEFSPCGNYFL--AI 111 Query: 211 KDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMD-HSLKLWRINSKR 269 D+ ++ N + + I H E+ + + + I G+D ++ W K Sbjct: 112 LDNVMK--NPGSINIYEIERDSATH--ELTKVSEEPIHKIITHEGLDAATVAGWSTKGKY 167 Query: 270 MMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIV 329 ++ K+ + +N ++ + D+H + +++ DL + Sbjct: 168 IIAGHKDGKISKYDVSN--------NYEYVDSIDLHEKSISDMQFSPDLTYFITSSR--- 216 Query: 330 CWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVW 389 D + S + +L +++ C + + +L G + + Sbjct: 217 ---------DTNSFLVDVSTLQVLKKYET-DCPLNTAVITPLKEFIILGGGQEAKDVTTT 266 Query: 390 DLEVEDPHKAKCTTLTHHKCG------AAIRQTSFSRDSSILIAVCDDASIWR 436 + + G + + S + + +D I Sbjct: 267 SANEGKFEARFYHKIFEEEIGRVQGHFGPLNTVAISPQGTSYASGGEDGFIRL 319 >4AEZ-A nrPDB Length = 401 Score = 80.4 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 51/331 (15%), Positives = 104/331 (31%), Gaps = 65/331 (19%) Query: 112 VFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGI 171 V A V ++ S + + + D + W+ L+V G+ Sbjct: 106 VVAVALERNVYVWNADSGS----VSALAETDESTYVASVKWS----HDGSFLSVGLGNGL 157 Query: 172 IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGG 231 + I + + ++ GH + L ++ ++L S S+ A+ +++ G Sbjct: 158 VDIYDVESQTKLRTMAGHQARVGCLSWNR---HVLSSGSRSGAIHHHDVR--IANHQIGT 212 Query: 232 VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFIS 291 ++GH EV + G ++ S G D+ +++W S Sbjct: 213 LQGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARS------------------------ 248 Query: 292 QKIHFPDFSTRDIHRNYVDCVRWLG---DLILSKS--CENAIVCWKPGKMEDDIDKIKPS 346 P F+ + H V V W +L+ + + I W + Sbjct: 249 ---SIPKFTKTN-HNAAVKAVAWCPWQSNLLATGGGTMDKQIHFW--------------N 290 Query: 347 ESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTH 406 + + D + + +S + M G L +W K + Sbjct: 291 AATGARVNTVDAG-SQVTSLIWSPHSKEIMSTHGFPDNNLSIWS--YSSSGLTKQVDIPA 347 Query: 407 HKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 H + ++ S D IL D ++ W Sbjct: 348 HDT--RVLYSALSPDGRILSTAASDENLKFW 376 >3ACP-A nrPDB Length = 417 Score = 80.4 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 45/276 (16%), Positives = 91/276 (32%), Gaps = 29/276 (10%) Query: 163 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQT 222 + + G I++++ + H + I +LKF P L+S S+D L++W+++ Sbjct: 109 FILGTTEGDIKVLDSNFNLQREIDQAHVSEITKLKFFPS-GEALISSSQDMQLKIWSVKD 167 Query: 223 DTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNP 282 + + GHR V G ++S +D +++LW + ++ NP Sbjct: 168 G---SNPRTLIGHRATVTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKE--NP 222 Query: 283 NKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW--LGDLILSKSCENAIVCWKPGKMEDDI 340 + D +I + + + + G +++ I Sbjct: 223 HDGVNSIALFV--GTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITV---------- 270 Query: 341 DKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAK 400 S + C + + + G + G L WDL P Sbjct: 271 ---HNVFSKEQTIQLPSKFTCSCNSLTVDGNNA-NYIYAGYENGMLAQWDLR--SPECPV 324 Query: 401 CTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWR 436 L G I F+ ++ ++ D SI Sbjct: 325 GEFL--INEGTPINNVYFAA-GALFVSSGFDTSIKL 357 Score = 70.0 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 55/311 (17%), Positives = 106/311 (34%), Gaps = 30/311 (9%) Query: 36 DENDDA--VSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHN 93 DENDD ++++ N + N+ G + GKG K + +K + H Sbjct: 22 DENDDEFYINVDKNLNEIKEHKIVVLGNSRGVDA-GKGNTFEKVGSHLYKARL---DGH- 76 Query: 94 QPLFGVQFNWHSKEGDPLV----FATVGSNRVTLYEC---HSQGEIRLLQSY--VDADAD 144 FN ++G ++ + V + ++ + ++G+I++L S + + D Sbjct: 77 ----DFLFNTIIRDGSKMLKRADYTAVDTAKLQMRRFILGTTEGDIKVLDSNFNLQREID 132 Query: 145 ENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPN 204 + + S L + ++I + + +GH + ++ R Sbjct: 133 QAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLIGHRATVTDIAIIDR-GR 191 Query: 205 LLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSAD-YDLLGEKI--MSCGMDHSLK 261 +LS S D +RLW T T + F E D V S + ++ +S ++L+ Sbjct: 192 NVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTDRQLHEISTSKKNNLE 251 Query: 262 LWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILS 321 I N Q I P T + VD + I + Sbjct: 252 F----GTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSCNSLTVD--GNNANYIYA 305 Query: 322 KSCENAIVCWK 332 + W Sbjct: 306 GYENGMLAQWD 316 Score = 46.1 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 38/291 (13%), Positives = 77/291 (26%), Gaps = 84/291 (28%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVD 140 +F + + H + ++F G+ L+ ++ ++ ++ R L + Sbjct: 124 NFNLQREIDQAHVSEITKLKFFP---SGEALISSSQDM-QLKIWSVKDGSNPRTLIGHRA 179 Query: 141 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYV------------- 187 D + A G IR+ T I + Sbjct: 180 TVTDIAI---------IDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIA 230 Query: 188 -------------------------------GHGNAI----------------------- 193 GH + + Sbjct: 231 LFVGTDRQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSC 290 Query: 194 NELKFHPRDPNLLLSVSKDHALRLWNIQTDTL-VAIFGGVEGHRDEVLSADYDLLGEKIM 252 N L + N + + ++ L W++++ V F EG + + + G + Sbjct: 291 NSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEG--TPINNVYFAA-GALFV 347 Query: 253 SCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRD 303 S G D S+KL I+ E +N +SQ + D + Sbjct: 348 SSGFDTSIKLDIISDPESERPAIEFETPTFLVSNDDEVSQFCYVSDDESNG 398 >4OWR-A nrPDB Length = 339 Score = 79.6 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 46/289 (15%), Positives = 88/289 (30%), Gaps = 66/289 (22%) Query: 191 NAINELKFHPRD--PNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLG 248 ++I L F P N L++ S + +R W +Q D+ I + H VL + G Sbjct: 11 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQ-DSGQTIPKAQQMHTGPVLDVCWSDDG 69 Query: 249 EKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNY 308 K+ + D + K+W ++S + + I D + IH + Sbjct: 70 SKVFTASCDKTAKMWDLSSNQAIQ---------------------IAQHDAPVKTIH--W 106 Query: 309 VDCVRWLGDLILSKSCENAIVCWKPGKM-------------EDDID-------------- 341 + + +++ S + + W D+ Sbjct: 107 IKAPNY--SCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLI 164 Query: 342 --KIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKA 399 +++ S + Q + ALG+ G++ + + +P K Sbjct: 165 VYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKD 224 Query: 400 KCTTLTHHKCG---------AAIRQTSFSRDSSILIAVCDDASIWRWDR 439 T H G A+ +F L V D WD+ Sbjct: 225 NFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDK 273 Score = 59.2 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 45/343 (13%), Positives = 93/343 (27%), Gaps = 51/343 (14%) Query: 93 NQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEI--RLLQSYVDADADENFYTC 150 + + + F+ + G+ L+ + ++ V +E G+ + Q + D Sbjct: 10 DDSIGCLSFSPPTLPGNFLIAGSWAND-VRCWEVQDSGQTIPKAQQMHTGPVLDV----- 63 Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNL-LLSV 209 W+ D + A ++ + + Q I H + + + +++ Sbjct: 64 CWSDDG----SKVFTASCDKTAKMWDLSSNQAI-QIAQHDAPVKTIHWIKAPNYSCVMTG 118 Query: 210 SKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKR 269 S D L+ W+ ++ + + E AD + + Sbjct: 119 SWDKTLKFWDTRSSNPMMVLQLPE----RCYCADVIYPMAVVATA--------------- 159 Query: 270 MMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIV 329 I + P++ R K + +N S E + Sbjct: 160 ERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQN-------KPTGFALGSIEGRVA 212 Query: 330 CW--KPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLY 387 P D K SN T + + F LA G+ Sbjct: 213 IHYINPPNPAKDNFTFKCHRSNGTNTSAPQD-IYAVNGIAFHP--VHGTLATVGSDGRFS 269 Query: 388 VWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCD 430 WD A+ T + I F+ + +I Sbjct: 270 FWD------KDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 306 Score = 36.4 bits (82), Expect = 0.022, Method: Composition-based stats. Identities = 24/140 (17%), Positives = 44/140 (31%), Gaps = 20/140 (14%) Query: 79 KYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIR---LL 135 K+ +CV K+ N+P F S EG RV ++ + + Sbjct: 183 KHQHRCVAIFKDKQNKP---TGFALGSIEG-----------RVAIHYINPPNPAKDNFTF 228 Query: 136 QSYVDADADENFYTCAWTYDSNTSHPL---LAVAGSRGIIRIINPITMQCIKHYVGHGNA 192 + + + + + + HP+ LA GS G + +K Sbjct: 229 KCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQP 288 Query: 193 INELKFHPRDPNLLLSVSKD 212 I+ F+ + S D Sbjct: 289 ISACCFNHNGNIFAYASSYD 308 Score = 35.3 bits (79), Expect = 0.061, Method: Composition-based stats. Identities = 13/82 (15%), Positives = 24/82 (29%), Gaps = 5/82 (6%) Query: 358 YSQCDIWYMRFSM-DFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQT 416 I + FS L G+ + W+++ K + + Sbjct: 8 SPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQM----HTGPVLDV 63 Query: 417 SFSRDSSILIAVCDDASIWRWD 438 +S D S + D + WD Sbjct: 64 CWSDDGSKVFTASCDKTAKMWD 85 Score = 33.4 bits (74), Expect = 0.21, Method: Composition-based stats. Identities = 23/205 (11%), Positives = 56/205 (27%), Gaps = 35/205 (17%) Query: 90 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYT 149 H+ P+ + W V + ++ S + +LQ Sbjct: 95 AQHDAPVKTIH--WIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQL---------PER 143 Query: 150 CAWTYDSNTSHPLLAVAGSRGIIRIINPIT----MQCIKHYVGHGNAINELKFHPRDPNL 205 C Y ++ +P+ VA + + + + I+ + H + + N Sbjct: 144 C---YCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQH--RCVAIFKDKQNK 198 Query: 206 ---LLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDE------------VLSADYDLLGEK 250 S + + + I + HR V + + Sbjct: 199 PTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGT 258 Query: 251 IMSCGMDHSLKLWRINSKRMMNAIK 275 + + G D W +++ + + Sbjct: 259 LATVGSDGRFSFWDKDARTKLKTSE 283 >5OV3-A nrPDB Length = 381 Score = 78.1 bits (190), Expect = 8e-15, Method: Composition-based stats. Identities = 39/249 (15%), Positives = 74/249 (29%), Gaps = 15/249 (6%) Query: 203 PNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKL 262 LL D + +W+ T + I + H V S + G K++S D+ + Sbjct: 37 GTLLAVGCNDGRIVIWDFLTRGIAKI---ISAHIHPVCSLCWSRDGHKLVSASTDNIVSQ 93 Query: 263 WRINSKRMMNAIK-----ESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGD 317 W + S + Y+P N+ + P T ++ V V D Sbjct: 94 WDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSD 153 Query: 318 LILSKSCENAIVCWKPGKMEDDIDKIK-PSESNVTILGRFDYSQCDIWYMRFSMDFWQKM 376 L + S + G + I +K S+ V + Sbjct: 154 LNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSC 213 Query: 377 LALGNQVGKLYVWD-----LEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDD 431 + + V+D D L ++ FS D ++A Sbjct: 214 FLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSAR 273 Query: 432 A-SIWRWDR 439 +++ W++ Sbjct: 274 QHALYIWEK 282 Score = 48.4 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 16/81 (19%), Positives = 31/81 (38%), Gaps = 6/81 (7%) Query: 360 QCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFS 419 C + + + W +LA+G G++ +WD + + +S Sbjct: 23 DCISMALTCTFNRWGTLLAVGCNDGRIVIWDFL------TRGIAKIISAHIHPVCSLCWS 76 Query: 420 RDSSILIAVCDDASIWRWDRL 440 RD L++ D + +WD L Sbjct: 77 RDGHKLVSASTDNIVSQWDVL 97 >4PSX-B nrPDB Length = 401 Score = 76.9 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 42/253 (16%), Positives = 90/253 (35%), Gaps = 48/253 (18%) Query: 189 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLG 248 H I ++ P+DPN++ +++ L++ + ++ H+D + + L Sbjct: 117 HEEEITRARYMPQDPNIVATINGQGTTFLYSRSEG----LQSTLKFHKDNGYALSFSTLV 172 Query: 249 E-KIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRN 307 + +++S DH++ LW + S +P K R + +H + H Sbjct: 173 KGRLLSGSDDHTVALWEVGSG-----------GDPTKPVRTW--NDLHSDIINDNKWH-- 217 Query: 308 YVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMR 367 + DL + S ++ + +D+ + V F+ + Sbjct: 218 -----NFNKDLFGTVSEDSLLKI-------NDVRANNTTIDTVKCPQPFNT-------LA 258 Query: 368 FSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKC-GAAIRQTSFSRDSS-IL 425 FS +LA +Y++DL + L H A+ FS ++ Sbjct: 259 FS-HHSSNLLAAAGMDSYVYLYDL------RNMKEPLHHMSGHEDAVNNLEFSTHVDGVV 311 Query: 426 IAVCDDASIWRWD 438 ++ D + WD Sbjct: 312 VSSGSDNRLMMWD 324 Score = 60.7 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 41/222 (18%), Positives = 84/222 (37%), Gaps = 31/222 (13%) Query: 83 KCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDAD 142 K V + + H+ + +++ +K+ +F TV + + + + D Sbjct: 198 KPVRTWNDLHSDIINDNKWHNFNKD----LFGTVSEDSLLKIND-------VRANNTTID 246 Query: 143 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQ-CIKHYVGHGNAINELKFHPR 201 + S+ S LLA AG + + + M+ + H GH +A+N L+F Sbjct: 247 TVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDLRNMKEPLHHMSGHEDAVNNLEFSTH 306 Query: 202 DPNLLLSVSKDHALRLWNIQTDTLVAIFGGVE-----------GHRDEVLSADYDLLGE- 249 +++S D+ L +W+++ E GHR V D + Sbjct: 307 VDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPW 366 Query: 250 KIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFIS 291 + S ++ L++W + +++ P K N+ IS Sbjct: 367 LVASAEEENILQVW-----KCSHSLP--IVGGPPKVNKDIIS 401 Score = 56.1 bits (133), Expect = 3e-08, Method: Composition-based stats. Identities = 40/294 (13%), Positives = 86/294 (29%), Gaps = 56/294 (19%) Query: 158 TSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRL 217 ++A +G + + H + L F LLS S DH + L Sbjct: 129 QDPNIVATINGQGTTFLYSRSEG-LQSTLKFHKDNGYALSFSTLVKGRLLSGSDDHTVAL 187 Query: 218 WNIQTD----TLVAIFGGVEGHRDEVLSADY-DLLGEKIMSCGMDHSLKLWRINSKRMMN 272 W + + V + + H D + + + + + D LK+ + + Sbjct: 188 WEVGSGGDPTKPVRTWNDL--HSDIINDNKWHNFNKDLFGTVSEDSLLKINDVRANN--T 243 Query: 273 AIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWK 332 I P T H + +L+ + ++ + + Sbjct: 244 TIDTVKCPQPFNTL--------------AFSHHSS---------NLLAAAGMDSYVYLYD 280 Query: 333 PGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDL- 391 M++ + + E V + FS +++ G+ +L +WDL Sbjct: 281 LRNMKEPLHHMSGHEDAVN-------------NLEFSTHVDGVVVSSGS-DNRLMMWDLK 326 Query: 392 -----EVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSI---LIAVCDDASIWRW 437 + D + L G F + I + + ++ + W Sbjct: 327 QIGAEQTPDDAEDGVPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVW 380 >5K0Y-T nrPDB Length = 329 Score = 76.9 bits (187), Expect = 2e-14, Method: Composition-based stats. Identities = 41/300 (13%), Positives = 89/300 (29%), Gaps = 27/300 (9%) Query: 156 SNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHAL 215 N LL I+ + + + + Y+GH A+ + D +L+ S D++ Sbjct: 18 YNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVD-ADWDTKHVLTGSADNSC 76 Query: 216 RLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHS------LKLWRINSKR 269 RLW+ +T +A+ V + +D G IM D + + + Sbjct: 77 RLWDCETGKQLALLKT----NSAVRTCGFDFGGNIIM-FSTDKQMGYQCFVSFFDLRDPS 131 Query: 270 MMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIV 329 ++ E Y P ++ + + ++ +L E++ Sbjct: 132 QIDN-NEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQ 190 Query: 330 CWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMR--------FSMDFWQKMLALGN 381 + + S+ N L + + S ++ ++ G Sbjct: 191 INDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFRTEPPRELAALSPNYEHVVVGGGQ 250 Query: 382 QVGKL-----YVWDLEVEDPHKAKCTTLTHHKCG-AAIRQTSFSRDSSILIAVCDDASIW 435 + + + E H A K I +F D + +D + Sbjct: 251 EAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVR 310 Score = 73.0 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 41/256 (16%), Positives = 84/256 (32%), Gaps = 46/256 (17%) Query: 186 YVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYD 245 GH +I ++K++ R+ +LL +V+KD + +W G GH V D D Sbjct: 6 LQGHERSITQIKYN-REGDLLFTVAKDPIVNVWYSVNGE---RLGTYMGHTGAVWCVDAD 61 Query: 246 LLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIH 305 + +++ D+S +LW + + + +K + Sbjct: 62 WDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRT----------------------- 98 Query: 306 RNYVDCVRWLGDLILSKSCENAI--VCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDI 363 C G I+ S + + C+ D +I +E + I I Sbjct: 99 -----CGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCN----DSKI 149 Query: 364 WYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSS 423 + + + G++ G+L + + H I SR+ + Sbjct: 150 TSAVWGP--LGECIIAGHESGELN----QYSAKSGEVLVNVKEHSR--QINDIQLSREMT 201 Query: 424 ILIAVCDDASIWRWDR 439 + + D + +D Sbjct: 202 MFVTASKDNTAKLFDS 217 Score = 49.5 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 34/267 (12%), Positives = 76/267 (28%), Gaps = 100/267 (37%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDA-----DADE 145 H ++ V +W +K V N L++C + ++ LL++ D Sbjct: 50 GHTGAVWCVDADWDTKH----VLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGG 105 Query: 146 NF----------YTCAWTY-------DSNTSHPLLAVAGSR------------------- 169 N Y C ++ + + P + + + Sbjct: 106 NIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGH 165 Query: 170 --GIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVA 227 G + + + + + + H IN+++ R+ + ++ SKD+ +L++ T Sbjct: 166 ESGELNQYSAKSGEVLVNVKEHSRQINDIQLS-REMTMFVTASKDNTAKLFDSTTLEHQK 224 Query: 228 IFGG----------------------------------------------------VEGH 235 F V+GH Sbjct: 225 TFRTEPPRELAALSPNYEHVVVGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGH 284 Query: 236 RDEVLSADYDLLGEKIMSCGMDHSLKL 262 + S + G+ S G D +++ Sbjct: 285 FGPINSVAFHPDGKSYSSGGEDGYVRI 311 Score = 48.4 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 37/359 (10%), Positives = 90/359 (25%), Gaps = 96/359 (26%) Query: 88 LKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENF 147 L + H + + +++N +EGD +F V ++ + + + A Sbjct: 5 LLQGHERSITQIKYN---REGDL-LFTVAKDPIVNVWYSVNGERLGTYMGHTGAV----- 55 Query: 148 YTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLL 207 W D++ + + R+ + T + + +A+ F ++ Sbjct: 56 ----WCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKT-NSAVRTCGF--DFGGNII 108 Query: 208 SVSKDH-----------------------------------ALRLW-------------- 218 S D +W Sbjct: 109 MFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESG 168 Query: 219 --NIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE 276 N + + V+ H ++ ++ D++ KL+ + + Sbjct: 169 ELNQYSAKSGEVLVNVKEHSRQINDIQLSREMTMFVTASKDNTAKLFDSTTLEHQKTFR- 227 Query: 277 SYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKM 336 + R + ++ + + + GK Sbjct: 228 ------TEPPRELAALSPNYEHVVVGGGQE----------------AMDVTTTSTRIGKF 265 Query: 337 EDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED 395 E + E GR I + F D K + G + G + + + + Sbjct: 266 EARFFHLAFEEE----FGRVKGHFGPINSVAFHPD--GKSYSSGGEDGYVRIHYFDPQY 318 >5WBU-D nrPDB Length = 328 Score = 76.5 bits (186), Expect = 2e-14, Method: Composition-based stats. Identities = 44/300 (14%), Positives = 97/300 (32%), Gaps = 32/300 (10%) Query: 158 TSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRL 217 + +LA AG +R + C + + +N L+ P D +++ + H +R+ Sbjct: 12 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTP-DRSMIAAAGYQH-IRM 69 Query: 218 WNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRM------- 270 +++ ++ I +G + S + G + + G D + ++W + S+ + Sbjct: 70 YDLNSNNPNPII-SYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQ 128 Query: 271 MNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRN--------YVDCVRWLGDLILSK 322 +NA +PN+ Q + + H + D Sbjct: 129 VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMA 188 Query: 323 SCENA--IVCWK-PGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLAL 379 + + W G + D++ ++ P + RFS D +LA Sbjct: 189 AVNSTGNCYVWNLTGGIGDEVTQLIPKT-------KIPAHTRYALQCRFSPDST--LLAT 239 Query: 380 GNQVGKLYVWDLE--VEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRW 437 + +W + + + +FS DS ++ D W Sbjct: 240 CSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLW 299 Score = 73.0 bits (177), Expect = 3e-13, Method: Composition-based stats. Identities = 38/283 (13%), Positives = 83/283 (29%), Gaps = 76/283 (26%) Query: 98 GVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSN 157 Q N D + A G + +Y+ +S ++ ++N + + Sbjct: 44 DSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPII---SYDGVNKNIASV----GFH 96 Query: 158 TSHPLLAVAGSRGIIRIINPIT--MQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHAL 215 + G RI + + +QC + + IN + HP L++ + A+ Sbjct: 97 EDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQV-NAPINCVCLHPNQAELIV-GDQSGAI 154 Query: 216 RLWNIQTDTLVAIFGGVE------------------------------------------ 233 +W+++TD + E Sbjct: 155 HIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIP 214 Query: 234 -----GHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRP 288 H L + + +C D + K+WR ++ +M + NP +++R Sbjct: 215 KTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELS-IKSGNPGESSRG 273 Query: 289 FISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCW 331 ++ + I++ S +N W Sbjct: 274 WM-----------------WGCAFSGDSQYIVTASSDNLARLW 299 Score = 70.3 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 22/130 (16%), Positives = 43/130 (33%), Gaps = 14/130 (10%) Query: 153 TYDSNTSHPLLAVAGSRGIIRIINPITM------QCI--KHYVGHGNAINELKFHPRDPN 204 + + +A S G + N Q I H + +F P D Sbjct: 177 SAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSP-DST 235 Query: 205 LLLSVSKDHALRLWNIQTDTLVAIFGGVEGH-----RDEVLSADYDLLGEKIMSCGMDHS 259 LL + S D ++W +L+ G+ R + + + I++ D+ Sbjct: 236 LLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNL 295 Query: 260 LKLWRINSKR 269 +LW + + Sbjct: 296 ARLWCVETGE 305 Score = 66.9 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 41/239 (17%), Positives = 78/239 (32%), Gaps = 51/239 (21%) Query: 201 RDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRD-EVLSADYDLLGEKIMSCGMDHS 259 DP +L + DH +R W + H+D +V + + I + G Sbjct: 12 SDPVILATAGYDHTVRFWQAHSGICTRTVQ----HQDSQVNALEVTPDRSMIAAAGY-QH 66 Query: 260 LKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLI 319 ++++ +NS NPN P IS + ++ H + G + Sbjct: 67 IRMYDLNSN------------NPN----PIISYDGVNKNIASVGFHED--------GRWM 102 Query: 320 LSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLAL 379 + + W N+ F I + + Q L + Sbjct: 103 YTGGEDCTARIWDL------------RSRNLQCQRIFQ-VNAPINCVCLHPN--QAELIV 147 Query: 380 GNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 G+Q G +++WDL+ + H + I D+S + AV + + W+ Sbjct: 148 GDQSGAIHIWDLKTD--HNEQLIPEPEVS----ITSAHIDPDASYMAAVNSTGNCYVWN 200 Score = 58.0 bits (138), Expect = 8e-09, Method: Composition-based stats. Identities = 31/174 (17%), Positives = 54/174 (31%), Gaps = 23/174 (13%) Query: 88 LKEDHNQ---PLFGVQFNWHSKEGDPLVFATVGS-NRVTLYECHSQGEIRLLQSY---VD 140 LK DHN+ P V + D A V S ++ + Q Sbjct: 159 LKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKI 218 Query: 141 ADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHY--------VGHGNA 192 C ++ DS LLA + +I + Sbjct: 219 PAHTRYALQCRFSPDS----TLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGW 274 Query: 193 INELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDL 246 + F D +++ S D+ RLW ++T + +G GH+ V+ ++ Sbjct: 275 MWGCAFS-GDSQYIVTASSDNLARLWCVETGEIKREYG---GHQKAVVCLAFND 324 >5WLC-LJ nrPDB Length = 513 Score = 76.1 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 46/261 (17%), Positives = 95/261 (36%), Gaps = 53/261 (20%) Query: 49 NTERPDTPTN-TPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKE 107 +T RP T+ P P + + + W+ +Y+ + ++HN + + FN Sbjct: 2 STARPRIITSKAPLLPQQTTPEQRYWR----QYTSAQLV---KEHNS-VTHISFNPQHPH 53 Query: 108 GDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENF---------------YTCAW 152 FA S RV ++ ++ I+ + D +F + Sbjct: 54 D----FAVTSSTRVQIFSSRTRQVIKTFSRFKDVVYSASFRSDGKLLCAGDATGLVSVYD 109 Query: 153 TYDSNT--------------------SHPLLAVAGSRGIIRIINPITM-QCIKHYVGHGN 191 +Y+ T + +LA A + R+ + + G + Sbjct: 110 SYNPRTILLSINASTHPTHVTKFHTQDNKILATASDDRVTRLWDISNAYEPQLELTGATD 169 Query: 192 AINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKI 251 + L F P P+L+ + S D +RL++ T + + H V + + +I Sbjct: 170 YVRTLSFIPAAPHLVATGSYDGLIRLYD--TRSSGSTPIYSLNHDQPVENV-IAVSPTQI 226 Query: 252 MSCGMDHSLKLWRINSKRMMN 272 +SCG ++ K+W + S + + Sbjct: 227 VSCGGNN-FKVWDLTSNKKLY 246 Score = 50.7 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 32/251 (12%), Positives = 76/251 (30%), Gaps = 52/251 (20%) Query: 189 HGNAINELKFHPRDP-NLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247 H + + + F+P+ P + ++ S +++++ +T ++ F +D V SA + Sbjct: 39 HNS-VTHISFNPQHPHDFAVTSS--TRVQIFSSRTRQVIKTFSRF---KDVVYSASFRSD 92 Query: 248 GEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRN 307 G+ + + + ++ YNP +S H Sbjct: 93 GKLLCAGDATGLVSVYD--------------SYNPRT---ILLSINASTHPTHVTKFHT- 134 Query: 308 YVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMR 367 ++ + S + W + ++ + V + Sbjct: 135 ------QDNKILATASDDRVTRLWDISNAYEPQLELTGATDYVR-------------TLS 175 Query: 368 FSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIA 427 F ++A G+ G + ++D +L H + + S I Sbjct: 176 FIPAAPH-LVATGSYDGLIRLYDTRSSGS--TPIYSLNHDQPVENVIAV-----SPTQIV 227 Query: 428 VCDDASIWRWD 438 C + WD Sbjct: 228 SCGGNNFKVWD 238 >3W15-A nrPDB Length = 368 Score = 74.2 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 52/256 (20%), Positives = 102/256 (39%), Gaps = 29/256 (11%) Query: 194 NELKFHPRDPNLLLSVSKDHALRLWNIQ-TDTLVAIFGGVEGHRDEVLSADYDLLGEK-I 251 +L ++ N +L D LRL++ + +AIF H EV S +++L+ + Sbjct: 66 FDLAWNESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKE---HEREVFSCNWNLVNRQNF 122 Query: 252 MSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDC 311 +S D S+K+W K+ + + K P + + F+ +RN V Sbjct: 123 LSSSWDGSIKIWSPLRKQSLMTL-TPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVYQ 181 Query: 312 VRWLG---DLILSKSCENAIVCWKPGKMEDDIDKIKP-SESNVTILGRFDYSQCDIWYMR 367 ++ +L+LS S + DI +++N + + CD + + Sbjct: 182 AQFSPHDQNLVLSCSGNS-------YASLFDIRLPSGKNQNNFLVHSGLEALTCD--FNK 232 Query: 368 FSMDFWQKMLALGNQVGKLYVWDL-----EVEDPHKAKCTTLTHHKCGAAIRQTSFSR-D 421 + ++A G + +WD+ H + C + G AIR+ ++S Sbjct: 233 YRPY----VVATGGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHH 288 Query: 422 SSILIAVCDDASIWRW 437 S+IL++ D + W Sbjct: 289 SNILMSASYDMTCRIW 304 Score = 74.2 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 55/365 (15%), Positives = 118/365 (32%), Gaps = 72/365 (19%) Query: 92 HNQPL--FGVQFNWHSKE----GDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADE 145 H Q +GVQ++ F VG+ ++ + E G I + S++ D Sbjct: 7 HMQGFSGYGVQYSPFFDNRLAVAAGSNFGLVGNGKLFILEIDRSGRIVEVNSFLTQDC-- 64 Query: 146 NFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQ-CIKHYVGHGNAINELKFHPRDPN 204 + AW + + VA G +R+ + + I + H + ++ + Sbjct: 65 -LFDLAWN---ESHENQVLVAQGDGTLRLFDTTFKEFPIAIFKEHEREVFSCNWNLVNRQ 120 Query: 205 LLLSVSKDHALRLWNIQTDTLV------------------------AIFGGVEGHRDEVL 240 LS S D ++++W+ + F G+ +R+ V Sbjct: 121 NFLSSSWDGSIKIWSPLRKQSLMTLTPRPLEITKMVDPLNAIILKKKSFTGISKNRNCVY 180 Query: 241 SADYDLLGE-KIMSCGMDHSLKLWRIN------------SKRMMNAIKESYDYNPNKTNR 287 A + + ++SC + L+ I + + Y P Sbjct: 181 QAQFSPHDQNLVLSCSGNSYASLFDIRLPSGKNQNNFLVHSGLEALTCDFNKYRPYVVAT 240 Query: 288 PFISQKIHFPDF-----------------STRDIHRNYVDCVRWLG---DLILSKSCENA 327 + I D + H + V W ++++S S + Sbjct: 241 GGVDNAIRIWDIRMLNKNPGQLHNSSCINEIPNAHGLAIRKVTWSPHHSNILMSASYDMT 300 Query: 328 IVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCD--IWYMRFSMDFWQKMLALGNQVGK 385 W+ + + K + ++ T F+++Q ++ +S+ +A G Sbjct: 301 CRIWRDLSNDGAKETYKTNSTDATKGSIFNFTQHSEFVFGADWSLWGKPGYVASTAWDGN 360 Query: 386 LYVWD 390 L+VW+ Sbjct: 361 LFVWN 365 >5WYJ-BE nrPDB Length = 939 Score = 71.9 bits (174), Expect = 6e-13, Method: Composition-based stats. Identities = 25/140 (17%), Positives = 54/140 (38%), Gaps = 8/140 (5%) Query: 156 SNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHAL 215 + S L A+A I +I+ +T + ++ GH N I F P ++S S D + Sbjct: 551 YHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPE-GRWIVSASLDSTI 609 Query: 216 RLWNIQTDTLVAIFGGVEGHRDEVLS-ADYDLLGEKIMSCG-MDHSLKLWRINSKRMMNA 273 R W++ T + D V + + G+ + + + + +W ++ + Sbjct: 610 RTWDLPTGGCIDGIIV-----DNVATNVKFSPNGDLLATTHVTGNGICIWTNRAQFKTVS 664 Query: 274 IKESYDYNPNKTNRPFISQK 293 + + + P S + Sbjct: 665 TRTIDESEFARMALPSTSVR 684 Score = 66.9 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 26/209 (12%), Positives = 61/209 (29%), Gaps = 46/209 (22%) Query: 102 NWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHP 161 N E + ++ A ++ ++ R D ++ Sbjct: 421 NARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMS-------QCGN 473 Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221 + S G I I N + K Y H A+ + + ++S D + ++ Sbjct: 474 FGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMN-RKMVSCGLDGIVGFYDFN 532 Query: 222 TDTLV--------------------------------------AIFGGVEGHRDEVLSAD 243 TL+ + + GH + + + D Sbjct: 533 KSTLLGKLKLDAPITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFD 592 Query: 244 YDLLGEKIMSCGMDHSLKLWRINSKRMMN 272 + G I+S +D +++ W + + ++ Sbjct: 593 FSPEGRWIVSASLDSTIRTWDLPTGGCID 621 Score = 55.7 bits (132), Expect = 4e-08, Method: Composition-based stats. Identities = 32/208 (15%), Positives = 66/208 (31%), Gaps = 22/208 (10%) Query: 168 SRGIIRIINPITMQCIK-HY-VGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTL 225 R + + + + + + + N S + ++ ++N+Q+ L Sbjct: 436 DEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMS-QCGNFGFIGSSNGSITIYNMQSGIL 494 Query: 226 VAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKT 285 + H+ V D + K++SCG+D + + N ++ +K Sbjct: 495 RKKYKL---HKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLDAPITAMVY 551 Query: 286 NRPFISQKIHFPDFSTRD-------------IHRNYVDCVRWL--GDLILSKSCENAIVC 330 +R + D S H N + + G I+S S ++ I Sbjct: 552 HRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRT 611 Query: 331 WK-PGKMEDDIDKIKPSESNVTILGRFD 357 W P D + +NV D Sbjct: 612 WDLPTGGCIDGIIVDNVATNVKFSPNGD 639 Score = 48.8 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 58/438 (13%), Positives = 139/438 (31%), Gaps = 72/438 (16%) Query: 48 TNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSF---KCVNSLKEDHNQPLFGVQFNWH 104 T+ E PD T AP G + ++ K + ++K ++ + + F Sbjct: 201 TSNEFPDQITTAEPAPVLDIIALGTVTGEVIMFNMRKGKRIRTIKIPQSR-ISSLSF--- 256 Query: 105 SKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTS----H 160 +G + S + Y+ + I +L +N + ++ + + Sbjct: 257 RTDGSSHLSVGTSSGDLIFYDLDRRSRIHVL---------KNIHRESYGGVTQATFLNGQ 307 Query: 161 PLLAVAGSRGIIR--IINP-----------ITMQCIKHYVGHGNAINELKFHPRDPNLLL 207 P++ +G ++ + +P + ++ GH + + F + +L Sbjct: 308 PIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFML 367 Query: 208 SVSKDHALRLWNIQTD-TLVAIFGGVEGHRD--------------EVLSADYDL----LG 248 S SKD +L ++++ D + + +D E+++ + Sbjct: 368 SASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAIENARIGEW 427 Query: 249 EKIMSCGMD-HSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRN 307 E I++ D + W + +KR+ ++ D K S + N Sbjct: 428 ENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVK------SVAMSQCGNFGFIGSSN 481 Query: 308 YVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMR 367 + + IL K +D + + + G + + + Sbjct: 482 GSITIYNMQSGILR----KKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLL 537 Query: 368 FSMDFWQKMLAL---GNQVGKLYVWD----LEVEDPHKAKCTTLTHHKCGAAIRQTSFSR 420 + + A+ + D + ++ + L H I FS Sbjct: 538 GKLKLDAPITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHS--NRITAFDFSP 595 Query: 421 DSSILIAVCDDASIWRWD 438 + +++ D++I WD Sbjct: 596 EGRWIVSASLDSTIRTWD 613 Score = 44.5 bits (103), Expect = 9e-05, Method: Composition-based stats. Identities = 41/343 (11%), Positives = 102/343 (29%), Gaps = 51/343 (14%) Query: 113 FATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGII 172 V + V L+ + + + D ++A+ G + Sbjct: 180 LTVVTKSNVLLFNVRTGKLVFTSNEFPDQITTAEPAPVL---------DIIALGTVTGEV 230 Query: 173 RIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGV 232 + N + I+ + I+ L F + L + L +++ + + + + Sbjct: 231 IMFNMRKGKRIRTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDLDRRSRIHVLKNI 290 Query: 233 EGHRDE---VLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPF 289 HR+ V A + I++ G D+SLK +Y + + Sbjct: 291 --HRESYGGVTQATFLNGQPIIVTSGGDNSLK-----------------EYVFDPSLSQG 331 Query: 290 ISQKIHFPD--FSTRDIHRNYVDCVRWLGD---LILSKSCENAIVCW-----KPGKMEDD 339 + P +R H + + +LS S + + W K + ++ Sbjct: 332 SGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRS--LWSFSLRKDAQSQEM 389 Query: 340 IDKIKPSESNVTILGRFDYSQCD----IWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED 395 ++ + + G S+ + + W+ ++ WD+ Sbjct: 390 SQRLHKKQDGGRVGGSTIKSKFPEIVALAIENARIGEWENIITAHKDEKFARTWDMR--- 446 Query: 396 PHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWD 438 +K ++ + S+ + + SI ++ Sbjct: 447 -NKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYN 488 Score = 36.8 bits (83), Expect = 0.018, Method: Composition-based stats. Identities = 13/66 (19%), Positives = 23/66 (34%), Gaps = 1/66 (1%) Query: 153 TYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKD 212 +D + + A IR + T CI + N +KF P L + Sbjct: 590 AFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGIIV-DNVATNVKFSPNGDLLATTHVTG 648 Query: 213 HALRLW 218 + + +W Sbjct: 649 NGICIW 654 >4E5Z-B nrPDB Length = 436 Score = 71.5 bits (173), Expect = 8e-13, Method: Composition-based stats. Identities = 27/179 (15%), Positives = 66/179 (36%), Gaps = 16/179 (8%) Query: 91 DHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTC 150 + G++FN + F T + +R+ S N + C Sbjct: 162 GAGGSITGLKFNPLNTNQ----FYASSMEGTTRLQDFKGNILRVFAS----SDTINIWFC 213 Query: 151 AWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVS 210 + D + S ++ + G + ++N + + + + H + + +P L + S Sbjct: 214 --SLDVSASSRMVVTGDNVGNVILLN-MDGKELWNLRMHKKKVTHVALNPCCDWFLATAS 270 Query: 211 KDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKL-----WR 264 D +++W+++ A F HR V +A + G ++++ +++ W Sbjct: 271 VDQTVKIWDLRQVRGKASFLYSLPHRHPVNAACFSPDGARLLTTDQKSEIRVYSASQWD 329 Score = 54.9 bits (130), Expect = 6e-08, Method: Composition-based stats. Identities = 40/248 (16%), Positives = 74/248 (29%), Gaps = 47/248 (18%) Query: 194 NELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGE-KIM 252 L +HP P+ + SK + LWN F G + ++ L + Sbjct: 123 TSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDK-PTFIKGIGAGGSITGLKFNPLNTNQFY 181 Query: 253 SCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCV 312 + M+ + +L R F S F + D V Sbjct: 182 ASSMEGTTRLQDFKG----------------NILRVFASSDTINIWFCSLD--------V 217 Query: 313 RWLGDLILSK-SCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMD 371 ++++ + N I+ GK ++ K ++V + CD Sbjct: 218 SASSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVAL-----NPCCDW-------- 264 Query: 372 FWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDD 431 LA + + +WDL + +L H + FS D + L+ Sbjct: 265 ----FLATASVDQTVKIWDLRQVRGKASFLYSLPHRH---PVNAACFSPDGARLLTTDQK 317 Query: 432 ASIWRWDR 439 + I + Sbjct: 318 SEIRVYSA 325 Score = 47.2 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 31/185 (16%), Positives = 58/185 (31%), Gaps = 44/185 (23%) Query: 129 QGEIRLLQSYVDADADENFYTCAWTYDSNTSHP-LLAVAGSRGIIRIINP--ITMQCIKH 185 Q + L SY F A + + +HP +AV G I + N Sbjct: 100 QSFLHTLDSYRILQKAAPFDRRATSLAWHPTHPSTVAVGSKGGDIMLWNFGIKDKPTFIK 159 Query: 186 YVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV------------------- 226 +G G +I LKF+P + N + S + RL + + + L Sbjct: 160 GIGAGGSITGLKFNPLNTNQFYASSMEGTTRLQDFKGNILRVFASSDTINIWFCSLDVSA 219 Query: 227 ---------------------AIFGGVEGHRDEVLSADYDLLGE-KIMSCGMDHSLKLWR 264 + H+ +V + + + + +D ++K+W Sbjct: 220 SSRMVVTGDNVGNVILLNMDGKELWNLRMHKKKVTHVALNPCCDWFLATASVDQTVKIWD 279 Query: 265 INSKR 269 + R Sbjct: 280 LRQVR 284 >5N4A-A nrPDB Length = 771 Score = 70.3 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 26/193 (13%), Positives = 59/193 (30%), Gaps = 27/193 (13%) Query: 163 LAVAGSRGIIRIINPI--TMQCIKHYVG-----HGNAINELKFHPRDPNLLLSVSKDHAL 215 L I N + Q + H ++ K ++ D ++ Sbjct: 28 LFTCSDDQTIHKWNMLGEPEQKVSTLDAYFTDMHWYPVSSKKTQAGGTDVFAVACTDGSV 87 Query: 216 RLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK 275 ++ + +T + +EGH+ +S + G + + G D S+K+W + + + + Sbjct: 88 KILS-RTGRVEK---SIEGHKGACISLRWSYDGTALATAGEDGSVKIWS-RNGMLRSTLA 142 Query: 276 ESYDYNPN-------------KTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGD--LIL 320 ++ + + I + H V V W LI+ Sbjct: 143 QADSPVYSIVWAYDCDQLCYCTGSNVVIKSLSSNAKQNAWKAHDGVVLKVDWSPINHLII 202 Query: 321 SKSCENAIVCWKP 333 + + W Sbjct: 203 TGGEDCKYKVWDS 215 Score = 62.3 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 29/173 (16%), Positives = 61/173 (35%), Gaps = 19/173 (10%) Query: 92 HNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCA 151 H P+ + ++ G VFA ++ + + ++ + A + Sbjct: 61 HWYPVSSKK----TQAGGTDVFAVACTDGSVKILSRTGRVEKSIEGHKGA-----CISLR 111 Query: 152 WTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSK 211 W+YD LA AG G ++I + + + + D + L + Sbjct: 112 WSYDGTA----LATAGEDGSVKIW-SRNGMLRSTLAQADSPVYSIVWA-YDCDQLCYCTG 165 Query: 212 DHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 + + I++ + A + H VL D+ + I++ G D K+W Sbjct: 166 SNVV----IKSLSSNAKQNAWKAHDGVVLKVDWSPINHLIITGGEDCKYKVWD 214 >1PI6-A nrPDB Length = 615 Score = 70.0 bits (169), Expect = 2e-12, Method: Composition-based stats. Identities = 53/368 (14%), Positives = 109/368 (29%), Gaps = 55/368 (14%) Query: 82 FKCVNSLKEDHNQPLF--GVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYV 139 FK S + H Q F V+F+ S E V +++ ++ S ++ ++ Sbjct: 193 FKFSASDRTHHKQGSFVRDVEFSPDSGE---FVITVGSDRKISCFDGKSGEFLKYIEDDQ 249 Query: 140 DADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIK--HYVGHGNAINELK 197 + + +W A G+ IR+ + T +C++ ++ Sbjct: 250 EPVQG-GIFALSW-----LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVG 303 Query: 198 FHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMD 257 ++S+S D L + + D ++ + GH + + + ++S D Sbjct: 304 VVATGNGRIISLSLDGTLNFYELGHDEVLKT---ISGHNKGITALTVNP----LISGSYD 356 Query: 258 HSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGD 317 + W +S + + +K + H G Sbjct: 357 GRIMEWS-SSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHE--------FGS 407 Query: 318 LILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYS-------QCDIWYMRFSM 370 S N D + ++ ++ IL F + S Sbjct: 408 QPKVASANN-----------DGFTAVLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQ 456 Query: 371 DFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCD 430 ++ L GN + + DLEV K + S S + + A Sbjct: 457 NYVAVGLEEGNTIQVFKLSDLEVSFDLKTPLRAKPSY--------ISISPSETYIAAGDV 508 Query: 431 DASIWRWD 438 I +D Sbjct: 509 MGKILLYD 516 Score = 69.2 bits (167), Expect = 3e-12, Method: Composition-based stats. Identities = 52/351 (14%), Positives = 111/351 (31%), Gaps = 67/351 (19%) Query: 113 FATVGSN-RVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGI 171 FATVG++ + +++ + ++ ++ A T + + G Sbjct: 267 FATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQVGVVA------TGNGRIISLSLDGT 320 Query: 172 IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGG 231 + + +K GH I L +P L+S S D + W+ + Sbjct: 321 LNFYELGHDEVLKTISGHNKGITALTVNP-----LISGSYDGRIMEWSSSS--------M 367 Query: 232 VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFIS 291 + H + ++S D + ++ S D +LK+ + S + N F + Sbjct: 368 HQDHSNLIVSLD-NSKAQEYSSISWDDTLKV-----NGITKHEFGSQPKVASANNDGFTA 421 Query: 292 QKIHFPDFSTRDIHRNYV----------DCVRWLGDLILSKSCE-NAIVCWKPGKMEDDI 340 + D + V + + E N I +K +E Sbjct: 422 VLTNDDDLLILQSFTGDIIKSVRLNSPGSAVSLSQNYVAVGLEEGNTIQVFKLSDLEVSF 481 Query: 341 DKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAK 400 D P + Y+ S +A G+ +GK+ ++DL+ + ++ Sbjct: 482 DLKTPLRA-------------KPSYISISPSET--YIAAGDVMGKILLYDLQSREVKTSR 526 Query: 401 CTTLTHHKCGAAIRQTSFSR----------DSSILIAVCDDASIWRWDRLR 441 T + I S+ + ++ D +I+ + R Sbjct: 527 WAFRT-----SKINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKR 572 Score = 65.0 bits (156), Expect = 6e-11, Method: Composition-based stats. Identities = 34/248 (13%), Positives = 77/248 (31%), Gaps = 27/248 (10%) Query: 165 VAGSRGIIRIINPITMQ---CIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ 221 G G + + + + G+ + +++F P +++V D + ++ + Sbjct: 178 TVGDDGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGK 237 Query: 222 TDTLVAIFGG-VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMM-------NA 273 + + E + + + + L +K + G D ++++W + + + + Sbjct: 238 SGEFLKYIEDDQEPVQGGIFALSW-LDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQ 296 Query: 274 IKESYDYNPNKTNRPFISQKI----------HFPDFSTRDIHRNYVDCVRWLGDLILSKS 323 + N IS + H T H + + ++S S Sbjct: 297 LGNQQVGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNP--LISGS 354 Query: 324 CENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRF---SMDFWQKMLALG 380 + I+ W M D + S N S D + Q +A Sbjct: 355 YDGRIMEWSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASA 414 Query: 381 NQVGKLYV 388 N G V Sbjct: 415 NNDGFTAV 422 Score = 53.8 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 50/355 (14%), Positives = 108/355 (30%), Gaps = 41/355 (11%) Query: 96 LFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADE---NFYTCAW 152 + V+F+ +G + + S +V ++ E ++ V ++ +W Sbjct: 67 VTTVKFSPI--KGSQYLCSGDESGKVIVWGWTFDKESNSVEVNVKSEFQVLAGPISDISW 124 Query: 153 TYDSNTSHPLLAVAGSRGIIRII-NPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSK 211 ++ L V R + + + + GH IN P ++V Sbjct: 125 DFEG---RRLCVVGEGRDNFGVFISWDSGNSLGEVSGHSQRINACHLKQSRPMRSMTVGD 181 Query: 212 DHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL-GEKIMSCGMDHSLKLWRINSKRM 270 D ++ + A V ++ GE +++ G D + + S Sbjct: 182 DGSVVFYQGPPFKFSASDRTHHKQGSFVRDVEFSPDSGEFVITVGSDRKISCFDGKSGEF 241 Query: 271 MNAIKESYD-----------YNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGD-- 317 + I++ + + K I D +T + + + LG+ Sbjct: 242 LKYIEDDQEPVQGGIFALSWLDSQKFATVGADATIRVWDVTTSKCVQKWTLDKQQLGNQQ 301 Query: 318 ---------LILSKSCENAIVCWKPGK------MEDDIDKIKPSESNVTILGRFDYSQCD 362 I+S S + + ++ G + I N I G +D + Sbjct: 302 VGVVATGNGRIISLSLDGTLNFYELGHDEVLKTISGHNKGITALTVNPLISGSYDGRIME 361 Query: 363 IWYMRFSMDFWQKMLALGNQVGKLY---VWDLEVEDPHKAKCTTLTHHKCGAAIR 414 D +++L N + Y WD ++ K + K +A Sbjct: 362 WSSSSMHQDHSNLIVSLDNSKAQEYSSISWDDTLKVNGITKHEFGSQPKVASANN 416 Score = 44.5 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 23/121 (19%), Positives = 44/121 (36%), Gaps = 13/121 (10%) Query: 107 EGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTY------DSNTSH 160 + + A ++ LY+ S R +++ A +W + Sbjct: 498 PSETYIAAGDVMGKILLYDLQS----REVKTSRWAFRTSKINAISWKPAEKGANEEEIEE 553 Query: 161 PLLAVAGSRGIIRIINP-ITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWN 219 L+A I I + M+ IK H + +N L + P+ L+S D ++ WN Sbjct: 554 DLVATGSLDTNIFIYSVKRPMKIIKALNAHKDGVNNLLW--ETPSTLVSSGADACIKRWN 611 Query: 220 I 220 + Sbjct: 612 V 612 Score = 41.5 bits (95), Expect = 8e-04, Method: Composition-based stats. Identities = 22/143 (15%), Positives = 53/143 (37%), Gaps = 13/143 (9%) Query: 133 RLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQC-IKHYVGHGN 191 +L V D + S +A G I + + + + + + Sbjct: 473 KLSDLEVSFDLKTPLRAKPSYISISPSETYIAAGDVMGKILLYDLQSREVKTSRWAFRTS 532 Query: 192 AINELKFHP---------RDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSA 242 IN + + P + +L+ + S D + +++++ + I + H+D V + Sbjct: 533 KINAISWKPAEKGANEEEIEEDLVATGSLDTNIFIYSVKR--PMKIIKALNAHKDGVNNL 590 Query: 243 DYDLLGEKIMSCGMDHSLKLWRI 265 ++ ++S G D +K W + Sbjct: 591 LWETPST-LVSSGADACIKRWNV 612 >5A9Q-7 nrPDB Length = 360 Score = 68.8 bits (166), Expect = 4e-12, Method: Composition-based stats. Identities = 37/266 (13%), Positives = 81/266 (30%), Gaps = 35/266 (13%) Query: 189 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYD--L 246 H + I+++ F + + S D ++++W+ + H V + Sbjct: 11 HKDLIHDVSFD-FHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPE 69 Query: 247 LGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHR 306 G+ + SC D + +W E N R +R Sbjct: 70 FGQVLASCSFDRTAAVW------------EEIVGESNDKLRGQSHWVKRTTLVDSRTSVT 117 Query: 307 NYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYM 366 + + +G ++ + S + + ++ D+ + I + C Sbjct: 118 DVKFAPKHMGLMLATCSADGIVRIYE----APDVMNLSQWSLQHEISCKLS---CSCISW 170 Query: 367 RFSMDFWQ-KMLALGNQVG------KLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFS 419 S M+A+G+ K+ +++ AK TL + +F+ Sbjct: 171 NPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETL--MTVTDPVHDIAFA 228 Query: 420 RDS----SILIAVCDDASIWRWDRLR 441 + IL D I+ +R Sbjct: 229 PNLGRSFHILAIATKDVRIFTLKPVR 254 Score = 62.3 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 51/353 (14%), Positives = 113/353 (32%), Gaps = 54/353 (15%) Query: 86 NSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADE 145 S+ DH + V F++H + + V +++ G+ S+ Sbjct: 5 RSIAADHKDLIHDVSFDFHGRR----MATCSSDQSVKVWDKSESGDWHCTASWKT--HSG 58 Query: 146 NFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNA------------I 193 + + W + +LA + I + G + + Sbjct: 59 SVWRVTWAHP--EFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSV 116 Query: 194 NELKFHPRD-PNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIM 252 ++KF P+ +L + S D +R++ +V++ L +I Sbjct: 117 TDVKFAPKHMGLMLATCSADGIVRIYEAP----------------DVMNLSQWSLQHEI- 159 Query: 253 SCGMDHSLKLWRINSKRMMNAIK--ESYDYNPNKTNRPFI----SQKIHFPDFSTRDIHR 306 SC + S W +S R + + S D +PN + I + T Sbjct: 160 SCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVT 219 Query: 307 NYVDCVRWLGDLILS----KSCENAIVCWKPGKMEDDIDKI-KPSESNVTILGRFDYSQC 361 + V + + +L S + + + ++ P++ + I+ +FD Sbjct: 220 DPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNS 279 Query: 362 DIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIR 414 +W + + + +LA G + +W D K + G+ + Sbjct: 280 QVWRVSW--NITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGN---GSPVN 327 >5CXB-B nrPDB Length = 369 Score = 67.7 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 28/154 (18%), Positives = 54/154 (35%), Gaps = 13/154 (8%) Query: 123 LYECHSQGEIRLLQSYVDADADENFYTCAW--TYDSNTSHPLLAVAGSRGIIRIINP-IT 179 L+ +Q IR W ++D + L V + + ++ Sbjct: 215 LFFVATQRSIRCYDLQKLELVKIVQPGAKWISSFDVHPGGDNLVVGSYDKRLLWHDLDLS 274 Query: 180 MQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLW------NIQTDTLVAIFGGVE 233 + K H AI ++FH L S D +L+++ + + + ++ Sbjct: 275 NRPYKTMRFHTEAIRAVRFHKGGLPLFADASDDGSLQIFHGKVPNDQLENPTIVPVKMLK 334 Query: 234 GHRDE----VLSADYDLLGEKIMSCGMDHSLKLW 263 GH+ VL D+ +S G D + +LW Sbjct: 335 GHKVVNKLGVLDIDWHPREPWCVSAGADGTARLW 368 Score = 49.2 bits (115), Expect = 4e-06, Method: Composition-based stats. Identities = 17/99 (17%), Positives = 35/99 (35%), Gaps = 8/99 (8%) Query: 232 VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK-------ESYDYNPNK 284 GH V S D G + + G D ++++W + + R + ++K + + P K Sbjct: 17 FRGHEGRVRSVAIDPTGVALATGGDDGTVRVWELLTGRQVWSVKLNGDEAVNTVRWRPTK 76 Query: 285 TNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKS 323 ++ F H + + IL+ Sbjct: 77 DT-FILAAAAGEDIFLMIPTHPSVTPALDQASRDILNAG 114 Score = 47.2 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 15/109 (13%), Positives = 32/109 (29%), Gaps = 22/109 (20%) Query: 186 YVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYD 245 + GH + + P L + D +R+W + T +V S + Sbjct: 17 FRGHEGRVRSVAIDPT-GVALATGGDDGTVRVWELLTGR-------------QVWSVKLN 62 Query: 246 LLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKI 294 ++++ WR + A D P ++ + Sbjct: 63 GDEAV-------NTVR-WRPTKDTFILAAAAGEDIFLMIPTHPSVTPAL 103 Score = 40.3 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 13/82 (15%), Positives = 29/82 (35%), Gaps = 7/82 (8%) Query: 131 EIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCI--KHYVG 188 +Q + + + A LA G G +R+ +T + + G Sbjct: 8 PFPTVQQTIFRGHEGRVRSVAIDPTGVA----LATGGDDGTVRVWELLTGRQVWSVKLNG 63 Query: 189 HGNAINELKFHPRDPNLLLSVS 210 A+N +++ P +L+ + Sbjct: 64 -DEAVNTVRWRPTKDTFILAAA 84 >4G56-B nrPDB Length = 357 Score = 66.9 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 30/237 (12%), Positives = 72/237 (30%), Gaps = 28/237 (11%) Query: 112 VFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGI 171 + S V L+E + + + + D ++ G Sbjct: 108 ILVASDSGAVELWEILEKESLLVNKFAKYEHDDIVKTLSVFS-----DGTQAVSGGKDFS 162 Query: 172 IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGG 231 +++ + +K Y H + +N + P + LS +D + LW+ + Sbjct: 163 VKVWDLSQKAVLKSYNAHSSEVNCVAACPGKDTIFLSCGEDGRILLWDTRKPKPATRIDF 222 Query: 232 VEGHRDEV-LSADYDLLGEKIMSCGMDHS-----LKLWRINSKRMMN-AIKESYDYNPNK 284 D + S + + +CG D + + + +S + + + Sbjct: 223 CA--SDTIPTSVTWHPEKDDTFACG-DETGNVSLVNIKNPDSAQTSAVHSQNITGLAYSY 279 Query: 285 TNRPFISQKIHFPDFSTRDI----------HRNYVDCVRWLG---DLILSKSCENAI 328 + PF++ + D HR++V V W + ++ + Sbjct: 280 HSSPFLASISEDCTVAVLDADFSEVFRDLSHRDFVTGVAWSPLDHSKFTTVGWDHKV 336 Score = 28.0 bits (60), Expect = 8.1, Method: Composition-based stats. Identities = 12/98 (12%), Positives = 29/98 (29%), Gaps = 17/98 (17%) Query: 305 HRNYVDCVRWL--GDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCD 362 H + V + G +S + ++ W + +L ++ + Sbjct: 138 HDDIVKTLSVFSDGTQAVSGGKDFSVKVWDLSQK--------------AVLKSYNAHSSE 183 Query: 363 IWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAK 400 + + L+ G G++ +WD P Sbjct: 184 VNCVAACPGKDTIFLSCGE-DGRILLWDTRKPKPATRI 220 >5CXC-A nrPDB Length = 510 Score = 66.9 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 47/295 (15%), Positives = 81/295 (27%), Gaps = 36/295 (12%) Query: 160 HPLLAVAGSRGIIRIINPITMQCIKHYV-----GHGNAINELKFHPRDPNLLLSVSKDHA 214 + A G++RI N + I GH +I KF + L S D Sbjct: 158 QERVLSASYDGLLRIWN-ASGSVIATSPSGSHGGHTASIKAAKF--LTSDRLASAGMDRT 214 Query: 215 LRLW-----NIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKR 269 +R+W + T L + GH V D D + I++ D ++ W + Sbjct: 215 VRVWKYTESDHFTGELKPTLE-LYGHTGSVDWLDVDGHSKHILTASADGAIGFWSASKAS 273 Query: 270 MMNAIKESYDYNPNKTNRPFIS--QKIHFPDFSTRDIHRNYVDCVRWLG---DLILSKSC 324 R S IH + + S S Sbjct: 274 APEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTVAYSASQ 333 Query: 325 ENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVG 384 ++ + +D + L S + +LA G Sbjct: 334 DHTVRT---------LDLTTGQVVSTLTLTHPLLSLSALT----RAGTTSPLLAAGTSAR 380 Query: 385 KLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSI-LIAVCDDASIWRWD 438 + + D + T H + S S ++ L++ D + WD Sbjct: 381 HITMVDPRASSATTSVMTLRGH---ANKVVSLSPSPENEYSLVSGSHDGTCRVWD 432 Score = 65.3 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 25/171 (14%), Positives = 57/171 (33%), Gaps = 6/171 (3%) Query: 165 VAGSRGIIRIINPITMQCIKHYV-GHGN-AINELKFHPRDPNLLLSVSKDHALRLWNIQT 222 A +R ++ T Q + H +++ L LL + + + + + + Sbjct: 330 SASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDPRA 389 Query: 223 DTLVAIFGGVEGHRDEVLSADYDLLGEK-IMSCGMDHSLKLWRINSKRMMNAIKESYDYN 281 + + GH ++V+S E ++S D + ++W + S R + S Sbjct: 390 SSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVWDLRSVRPATKEEGSLGGV 449 Query: 282 PNKTNRPFISQKIHFPDFSTRDIHRNY--VDCVRWLGDLILSKSCENAIVC 330 ++ + R + + V V W I S + + Sbjct: 450 -SEPVYVIERESWASKGKKKRPVAGDGCKVFSVVWDKLGIFSGGEDKKVQV 499 Score = 59.9 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 38/205 (18%), Positives = 67/205 (32%), Gaps = 40/205 (19%) Query: 87 SLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADEN 146 L H P F+ ++ A+ TL + + + L Sbjct: 306 GLWSIHTAPATAAIFDP--RDRTVAYSASQDHTVRTL-DLTTGQVVSTL------TLTHP 356 Query: 147 FYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQ---CIKHYVGHGNAINELKFHPRDP 203 + + + T+ PLLA S I +++P + GH N + L P + Sbjct: 357 LLSLSALTRAGTTSPLLAAGTSARHITMVDPRASSATTSVMTLRGHANKVVSLSPSPENE 416 Query: 204 NLLLSVSKDHALRLWNIQT-DTLVAIFGGVEGHRDEVL---------------------- 240 L+S S D R+W++++ G + G + V Sbjct: 417 YSLVSGSHDGTCRVWDLRSVRPATKEEGSLGGVSEPVYVIERESWASKGKKKRPVAGDGC 476 Query: 241 ---SADYDLLGEKIMSCGMDHSLKL 262 S +D LG I S G D +++ Sbjct: 477 KVFSVVWDKLG--IFSGGEDKKVQV 499 Score = 59.2 bits (141), Expect = 4e-09, Method: Composition-based stats. Identities = 44/344 (12%), Positives = 96/344 (27%), Gaps = 73/344 (21%) Query: 106 KEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAV 165 + G V + + ++ S I S + + + LA Sbjct: 155 QPGQERVLSASYDGLLRIWNA-SGSVIATSPSGSHGGHTASIKAAKF-----LTSDRLAS 208 Query: 166 AGSRGIIRIINPI-------TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLW 218 AG +R+ ++ GH +++ L +L+ S D A+ W Sbjct: 209 AGMDRTVRVWKYTESDHFTGELKPTLELYGHTGSVDWLDVD-GHSKHILTASADGAIGFW 267 Query: 219 NI--------------------QTDTLVAIFGGVEG-------HRDEVLSADYDLLGEKI 251 + + ++ G H +A +D + Sbjct: 268 SASKASAPEPDASLLPGAHVSKRRKATSSVSTAQRGPLGLWSIHTAPATAAIFDPRDRTV 327 Query: 252 M-SCGMDHSLKLWRINSKRMMNAIK-ESYDYNPNKTNRPFISQKIHFPDFSTR------- 302 S DH+++ + + ++++ + + + R + + S R Sbjct: 328 AYSASQDHTVRTLDLTTGQVVSTLTLTHPLLSLSALTRAGTTSPLLAAGTSARHITMVDP 387 Query: 303 ------------DIHRNYVDCVRWLGD---LILSKSCENAIVCWKPGKMEDDIDKIKPSE 347 H N V + + ++S S + W D+ ++P+ Sbjct: 388 RASSATTSVMTLRGHANKVVSLSPSPENEYSLVSGSHDGTCRVW-------DLRSVRPAT 440 Query: 348 SNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVG-KLYVWD 390 LG I ++ +K G+ VWD Sbjct: 441 KEEGSLGGVSEPVYVIERESWASKGKKKRPVAGDGCKVFSVVWD 484 Score = 51.1 bits (120), Expect = 9e-07, Method: Composition-based stats. Identities = 23/193 (11%), Positives = 50/193 (25%), Gaps = 54/193 (27%) Query: 235 HRDEVLSADY--------------------DLLGEKIMSCGMDHSLKLWRINSKRMMNAI 274 H D V + D E+++S D L++W + Sbjct: 125 HDDWVSAVDVLSATSPAGRWSSAANSSAAVQPGQERVLSASYDGLLRIWNAS-------- 176 Query: 275 KESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL-GDLILSKSCENAIVCWKP 333 I + H + ++L D + S + + WK Sbjct: 177 ----------------GSVIATSPSGSHGGHTASIKAAKFLTSDRLASAGMDRTVRVWKY 220 Query: 334 GKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEV 393 + + ++KP+ + ++ D K + + G + W Sbjct: 221 TESDHFTGELKPT-------LELYGHTGSVDWLDV--DGHSKHILTASADGAIGFWSASK 271 Query: 394 EDPHKAKCTTLTH 406 + + L Sbjct: 272 ASAPEPDASLLPG 284 >2PM9-A nrPDB Length = 416 Score = 66.9 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 55/347 (15%), Positives = 113/347 (32%), Gaps = 57/347 (16%) Query: 101 FNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLL------QSYVDADADENFYTCAWTY 154 F W + LV TV + S E+ L + D F W+ Sbjct: 18 FAWSHDKIPLLVSGTVSGTVDANFSTDSSLELWSLLAADSEKPIASLQVDSKFNDLDWS- 76 Query: 155 DSNTSHPLLAVAGSRGIIRIINPITMQ----CIKHYVGHGNAINELKFHPRDPNLLLSVS 210 ++ ++A A G + + + + + H +++ +KF+ + N+L S Sbjct: 77 ---HNNKIIAGALDNGSLELYSTNEANNAINSMARFSNHSSSVKTVKFNAKQDNVLASGG 133 Query: 211 KDHALRLWNIQ--TDTLVAIFGGVEGHR----DEVLSADYDLL-GEKIMSCGMDHSLKLW 263 + + +W++ T++ G DEV+S ++ S G + +W Sbjct: 134 NNGEIFIWDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIW 193 Query: 264 RINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKS 323 + +K+ + + +PN + +S P STR + S Sbjct: 194 DLKAKKEVIHLS---YTSPNSGIKQQLSVVEWHPKNSTRVA--------------TATGS 236 Query: 324 C-ENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQ 382 + +I+ W +N + Q I + + +L+ G + Sbjct: 237 DNDPSILIWDL------------RNANTPLQTLNQGHQKGILSLDWCHQDEHLLLSSG-R 283 Query: 383 VGKLYVWDLE-----VEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSI 424 + +W+ E + P + T A S D+ I Sbjct: 284 DNTVLLWNPESAEQLSQFPARGNWCFKTKFAPEAPDLFACASFDNKI 330 Score = 61.5 bits (147), Expect = 7e-10, Method: Composition-based stats. Identities = 32/195 (16%), Positives = 72/195 (36%), Gaps = 8/195 (4%) Query: 73 WKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFAT-VGSNRVTLYECHSQGE 131 W KC S L + + + VFA+ SN ++++ ++ E Sbjct: 141 WDMNKCTESPSNYTPLTPGQSMSSVDEVISLAWNQSLAHVFASAGSSNFASIWDLKAKKE 200 Query: 132 I-RLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQ-CIKHYV-G 188 + L + ++ + W ++T + + I I + ++ G Sbjct: 201 VIHLSYTSPNSGIKQQLSVVEWHPKNSTRVATATGSDNDPSILIWDLRNANTPLQTLNQG 260 Query: 189 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLG 248 H I L + +D +LLLS +D+ + LWN ++ ++ F + + Sbjct: 261 HQKGILSLDWCHQDEHLLLSSGRDNTVLLWNPESAEQLSQFPARG---NWCFKTKFAPEA 317 Query: 249 EKIMSC-GMDHSLKL 262 + +C D+ +++ Sbjct: 318 PDLFACASFDNKIEV 332 >5WLC-SG nrPDB Length = 573 Score = 65.7 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 58/409 (14%), Positives = 116/409 (28%), Gaps = 64/409 (15%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGE----IRLLQ 136 + C++ + N+ F N +G + ++T Y+ + ++ + Sbjct: 156 NLTCISCFQPVLNKYTFEESSNGDKNKGRLFAYTVSKDLQLTKYDITDFSKRPKKLKYAK 215 Query: 137 S-------------YVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCI 183 + T A + D + G + + + ++ + Sbjct: 216 GGAKYIPTSKHEYENTTEGHYDEILTVAASPDG----KYVVTGGRDRKLIVWSTESLSPV 271 Query: 184 KHYVG--HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLS 241 K + L F L S + D +R ++I + + I + GH D V Sbjct: 272 KVIPTKDRRGEVLSLAFRKNSDQLYASCA-DFKIRTYSINQFSQLEI---LYGHHDIVED 327 Query: 242 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQ--------K 293 + + D + LW+I + + P K R ++ + + Sbjct: 328 ISALAMERCVTVGARDRTAMLWKIPDE---TRLTFRGGDEPQKLLRRWMKENAKEGEDGE 384 Query: 294 IHFPDFSTRD--IHRNYVDCVRWLGDL-ILSKSCENAIVCWK-----------------P 333 + +PD S +D V + D ++ S I W P Sbjct: 385 VKYPDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILP 444 Query: 334 GKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEV 393 +DI E + W + + G+ G L VW + Sbjct: 445 EPSFNDISGETDEELR-KRQLQGKKLLQPFWITSLYAIPYSNVFISGSWSGSLKVWKISD 503 Query: 394 EDPHKAKCTTLTHHKCGAAIRQTSFSRDS-----SILIAVCDDASIWRW 437 L+ K Q S IL ++ + + RW Sbjct: 504 NLRSFELLGELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRLGRW 552 Score = 46.1 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 28/217 (12%), Positives = 59/217 (27%), Gaps = 24/217 (11%) Query: 121 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYD--SNTSHPLLAVAGSRGIIRIINPI 178 + + + E + +++ + C + D S G I + + Sbjct: 369 LRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSLA 428 Query: 179 TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDE 238 + I + + P + +S D LR +Q L+ F Sbjct: 429 KKKPIFT----ERIAHGILPEPSFND--ISGETDEELRKRQLQGKKLLQPF--------W 474 Query: 239 VLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPD 298 + S +S SLK+W+I+ + + + + Sbjct: 475 ITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGKHGK 534 Query: 299 FSTR------DIHR--NYVDCVRWLGDLILSKSCENA 327 R HR ++ V + I S + Sbjct: 535 EKFRILASIAKEHRLGRWIANVSGARNGIYSAVIDQT 571 >4J0X-A nrPDB Length = 451 Score = 65.7 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 58/409 (14%), Positives = 116/409 (28%), Gaps = 64/409 (15%) Query: 81 SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGE----IRLLQ 136 + C++ + N+ F N +G + ++T Y+ + ++ + Sbjct: 34 NLTCISCFQPVLNKYTFEESSNGDKNKGRLFAYTVSKDLQLTKYDITDFSKRPKKLKYAK 93 Query: 137 S-------------YVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCI 183 + T A + D + G + + + ++ + Sbjct: 94 GGAKYIPTSKHEYENTTEGHYDEILTVAASPDG----KYVVTGGRDRKLIVWSTESLSPV 149 Query: 184 KHYVG--HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLS 241 K + L F L S + D +R ++I + + I + GH D V Sbjct: 150 KVIPTKDRRGEVLSLAFRKNSDQLYASCA-DFKIRTYSINQFSQLEI---LYGHHDIVED 205 Query: 242 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQ--------K 293 + + D + LW+I + + P K R ++ + + Sbjct: 206 ISALAMERCVTVGARDRTAMLWKIPDE---TRLTFRGGDEPQKLLRRWMKENAKEGEDGE 262 Query: 294 IHFPDFSTRD--IHRNYVDCVRWLGDL-ILSKSCENAIVCWK-----------------P 333 + +PD S +D V + D ++ S I W P Sbjct: 263 VKYPDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSLAKKKPIFTERIAHGILP 322 Query: 334 GKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEV 393 +DI E + W + + G+ G L VW + Sbjct: 323 EPSFNDISGETDEELR-KRQLQGKKLLQPFWITSLYAIPYSNVFISGSWSGSLKVWKISD 381 Query: 394 EDPHKAKCTTLTHHKCGAAIRQTSFSRDS-----SILIAVCDDASIWRW 437 L+ K Q S IL ++ + + RW Sbjct: 382 NLRSFELLGELSGAKGVVTKIQVVESGKHGKEKFRILASIAKEHRLGRW 430 Score = 46.1 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 28/217 (12%), Positives = 59/217 (27%), Gaps = 24/217 (11%) Query: 121 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYD--SNTSHPLLAVAGSRGIIRIINPI 178 + + + E + +++ + C + D S G I + + Sbjct: 247 LRRWMKENAKEGEDGEVKYPDESEAPLFFCEGSIDVVSMVDDFHFITGSDNGNICLWSLA 306 Query: 179 TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDE 238 + I + + P + +S D LR +Q L+ F Sbjct: 307 KKKPIFT----ERIAHGILPEPSFND--ISGETDEELRKRQLQGKKLLQPF--------W 352 Query: 239 VLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPD 298 + S +S SLK+W+I+ + + + + Sbjct: 353 ITSLYAIPYSNVFISGSWSGSLKVWKISDNLRSFELLGELSGAKGVVTKIQVVESGKHGK 412 Query: 299 FSTR------DIHR--NYVDCVRWLGDLILSKSCENA 327 R HR ++ V + I S + Sbjct: 413 EKFRILASIAKEHRLGRWIANVSGARNGIYSAVIDQT 449 >5FA5-B nrPDB Length = 367 Score = 65.3 bits (157), Expect = 5e-11, Method: Composition-based stats. Identities = 34/241 (14%), Positives = 80/241 (33%), Gaps = 26/241 (10%) Query: 108 GDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAG 167 G+ + S V L+E + E ++ + + D+ T + +S Sbjct: 115 GERGILVASDSGAVELWEL-DENETLIVSKFCKYEHDDIVSTVSVL----SSGTQAVSGS 169 Query: 168 SRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ-TDTLV 226 I++ + + Y H + + P ++ LS S+D+ + LW+ + Sbjct: 170 KDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPAS 229 Query: 227 AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDH-SLKLWRINSKRMMNAIKES----YDYN 281 I G+ S + ++ G ++ ++ L S + + Sbjct: 230 QIGCSAPGYLPT--SLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLV 287 Query: 282 PNKTNRPFISQKIHFPDFSTRD----------IHRNYVDCVRWLG---DLILSKSCENAI 328 + + PF++ + D HR++V W L+ + ++ + Sbjct: 288 FSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQV 347 Query: 329 V 329 V Sbjct: 348 V 348 Score = 33.4 bits (74), Expect = 0.19, Method: Composition-based stats. Identities = 17/141 (12%), Positives = 42/141 (29%), Gaps = 22/141 (15%) Query: 301 TRDIHRNYVDCVRWL--GDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDY 358 + H + V V L G +S S + I W + + + + VT + Sbjct: 145 CKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVV-LSSYRAHAAQVTCVA---- 199 Query: 359 SQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSF 418 + + ++ ++ +WD P + G ++ Sbjct: 200 ----------ASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAP----GYLPTSLAW 245 Query: 419 SR-DSSILIAVCDDASIWRWD 438 S + + ++ ++ D Sbjct: 246 HPQQSEVFVFGDENGTVSLVD 266 >5A9Q-0 nrPDB Length = 380 Score = 65.0 bits (156), Expect = 6e-11, Method: Composition-based stats. Identities = 26/189 (13%), Positives = 64/189 (33%), Gaps = 16/189 (8%) Query: 109 DPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGS 168 +P + R+ L+ + +R + +N + + P + S Sbjct: 141 NPEIVTVGEDGRINLFRADHKEAVRTI---------DNADSSTLHAVTFLRTPEILTVNS 191 Query: 169 RGIIRIINPITMQ----CIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDT 224 G ++I + I G ++ + HP +++ + +D L +W+++ T Sbjct: 192 IGQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGT 251 Query: 225 LVAIFGGVEGHRDEVLSADYDLLGEK-IMSCGMDHSLKLWRINSKRMMNAIKESYDYNPN 283 + ++ H E+ + + + +C D SL W ++ + + Sbjct: 252 M--PVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGGRSS 309 Query: 284 KTNRPFISQ 292 IS Sbjct: 310 TFLSHSISN 318 Score = 59.9 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 32/244 (13%), Positives = 77/244 (31%), Gaps = 14/244 (5%) Query: 92 HNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQ-----SYVDADADEN 146 H+ + +QF + + A + VT++ H + + ++ Sbjct: 73 HHGDVMDLQFFDQER-----IVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSP 127 Query: 147 FYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLL 206 Y+ A ++P + G G I + + ++ ++ R P + Sbjct: 128 SYSSAPCTGVVCNNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPE-I 186 Query: 207 LSVSKDHALRLWNIQT-DTLVAIFGGVEGHRDEVLSADYDLLGEKIM-SCGMDHSLKLWR 264 L+V+ L++W+ + + + G R + D + ++ + G D L +W Sbjct: 187 LTVNSIGQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWD 246 Query: 265 INSKRM-MNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKS 323 + M ++ +K P + + H + V L Sbjct: 247 VRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWDASTDVPEKSSLFHQGG 306 Query: 324 CENA 327 + Sbjct: 307 RSST 310 Score = 41.5 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 44/289 (15%), Positives = 97/289 (33%), Gaps = 46/289 (15%) Query: 190 GNAINELKFHP------RDPNLLLSVSKDHA---LRLWNIQTDTLVAIFGGVEG------ 234 I++ ++ P + + S D+ + LW+I + GG EG Sbjct: 10 SQKISKTRWRPLPPGSLQTAETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLC 69 Query: 235 ---HRDEVLSADYDLLGEKIMSCGMDH--SLKLWRINSKRM------MNAIKESYDYNPN 283 H +V+ + E+I++ ++ L N++ + A + +P+ Sbjct: 70 DIRHHGDVMDLQF-FDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPS 128 Query: 284 KTNRPFISQKIHFPDFSTRD-------IHRNYVDCVRWLGDLILSKSCENAIVCWKPGKM 336 ++ P + P+ T ++ + VR + + S + Sbjct: 129 YSSAPCTGVVCNNPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILT 188 Query: 337 EDDIDKIKPSE-----SNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDL 391 + I ++K + + + + + + + + ++A G Q G L +WD Sbjct: 189 VNSIGQLKIWDFRQQGNEPSQILSLTGDRVPLHCVDRHPNQQH-VVATGGQDGMLSIWD- 246 Query: 392 EVEDPHKAKCTTLTHHKCGAAIRQTSFSR-DSSILIAVCDDASIWRWDR 439 V H A + + F + L +D S+W WD Sbjct: 247 -VRQGTMPVSLLKAHE---AEMWEVHFHPSNPEHLFTCSEDGSLWHWDA 291 >6BX3-B nrPDB Length = 412 Score = 64.2 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 45/276 (16%), Positives = 97/276 (35%), Gaps = 40/276 (14%) Query: 195 ELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEG-HRDEVLSADYDLLGEKIMS 253 L+F P L L + AL ++++ T + + G + G H + S + G +++ Sbjct: 30 CLQFSPCGDYLALGCAN-GALVIYDMDTFRPICVPGNMLGAHVRPITSIAWSPDGRLLLT 88 Query: 254 CGMDHSLKLWRINSKRMMNAIKESYDYNP-------NKTNRPFISQKIHFPDFSTRDIHR 306 D S+KLW ++ + +KE +P + R ++ D D Sbjct: 89 SSRDWSIKLWDLS--KPSKPLKEIRFDSPIWGCQWLDAKRRLCVATIFEESDAYVIDFSN 146 Query: 307 NYVDCV------RWLGDL---------ILSKSCENAIVCWKPGKMEDDIDKIKPSESNVT 351 + V + + L + N I+ D ++ Sbjct: 147 DPVASLLSKSDEKQLSSTPDHGYVLVCTVHTKHPNIIIVGTSKGWLDFYKFHSLYQT--E 204 Query: 352 ILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGA 411 + + +I ++ S + + LA+ + +++ ++D + A TL HK Sbjct: 205 CIHSLKITSSNIKHLIVSQN--GERLAINCSDRTIRQYEISIDDENSAVELTL-EHKYQD 261 Query: 412 AIRQ-----TSFSRD-SSILIA---VCDDASIWRWD 438 I + FS + + L+A ++ W+ Sbjct: 262 VINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWE 297 Score = 47.2 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 28/325 (8%), Positives = 104/325 (32%), Gaps = 46/325 (14%) Query: 92 HNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCA 151 H +P+ + ++ + L+ + + L++ + + + D + C Sbjct: 70 HVRPITSIAWSPDGR----LLLTSSRDWSIKLWDLS-----KPSKPLKEIRFDSPIWGCQ 120 Query: 152 W---------TYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRD 202 W S + + + +++ + + H + H + Sbjct: 121 WLDAKRRLCVATIFEESDAYVIDFSNDPVASLLSKSDEKQLSSTPDH-GYVLVCTVHTKH 179 Query: 203 PNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKL 262 PN+++ + L + + ++ + GE++ D +++ Sbjct: 180 PNIIIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQ 239 Query: 263 WRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSK 322 + I+ +A++ + ++ +++ ++ ++W L + Sbjct: 240 YEISIDDENSAVELTLEHK-----------------------YQDVINKLQWNCILFSNN 276 Query: 323 SCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQ 382 + E + + ++ T++ + ++ ++ + + +++ G + Sbjct: 277 TAEYLV---ASTHGSSAHELYIWETTSGTLVRVLEGAEEELIDINWDFYSM-SIVSNGFE 332 Query: 383 VGKLYVWDLEVEDPHKAKCTTLTHH 407 G +YVW + + A Sbjct: 333 SGNVYVWSVVIPPKWSALAPDFEEV 357 >3F3P-A nrPDB Length = 351 Score = 63.4 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 37/283 (13%), Positives = 93/283 (32%), Gaps = 41/283 (14%) Query: 140 DADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRII----NPITMQCIKHYVGHGNAINE 195 D+ D+ + + + +A S I++ + + + H ++I Sbjct: 7 DSGHDDLVHDVVYDFYGRH----VATCSSDQHIKVFKLDKDTSNWELSDSWRAHDSSIVA 62 Query: 196 LKF-HPRDPNLLLSVSKDHALRLWNIQ------TDTLVAIFGGVEGHRDEVLSADYDL-- 246 + + P ++ S S D ++LW + + + + S + Sbjct: 63 IDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAPAH 122 Query: 247 LGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHR 306 LG K+ G D L+L+ P+ ++ ++ + H Sbjct: 123 LGLKLACLGNDGILRLYD--------------ALEPSDLRSWTLTSEMKVLSIPPAN-HL 167 Query: 307 NYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYM 366 C+ W S E +E I + + + + + + I + Sbjct: 168 QSDFCLSWCPSRF---SPEKL----AVSALEQAIIYQRGKDGKLHVAAKLPGHKSLIRSI 220 Query: 367 RFSMD--FWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHH 407 ++ W +++A G + G++ ++ + + A +LT+ Sbjct: 221 SWAPSIGRWYQLIATGCKDGRIRIFKITEKLSPLASEESLTNS 263 Score = 53.4 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 43/279 (15%), Positives = 92/279 (32%), Gaps = 42/279 (15%) Query: 99 VQFNWHSKEGDPLVFATVGSNRVTLYECH-SQGEIRLLQSYVDADADENFYTC-AWTYDS 156 V +W S E ++ + V L+E Q E + +++ + + + Sbjct: 61 VAIDWASPEYGRIIASASYDKTVKLWEEDPDQEECSGRRWNKLCTLNDSKGSLYSVKFAP 120 Query: 157 NTSHPLLAVAGSRGIIRIINPITMQCIKHYV-------------GHGNAINELKFHPR-- 201 LA G+ GI+R+ + + ++ + H + L + P Sbjct: 121 AHLGLKLACLGNDGILRLYDALEPSDLRSWTLTSEMKVLSIPPANHLQSDFCLSWCPSRF 180 Query: 202 DPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL----GEKIMSCGMD 257 P L + + A+ ++ D + + + GH+ + S + + I + D Sbjct: 181 SPEKLAVSALEQAI-IYQRGKDGKLHVAAKLPGHKSLIRSISWAPSIGRWYQLIATGCKD 239 Query: 258 HSLKLWRINSKRMMNAIKESYD------------------YNPNKTNRPFISQKIHFPDF 299 +++++I K A +ES + N + + + Sbjct: 240 GRIRIFKITEKLSPLASEESLTNSNMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELL 299 Query: 300 STRDIHRNYVDCVRWL--GDLILSKSCENAIVCWKPGKM 336 S D H V V W G ++ S + + WK Sbjct: 300 SEHDDHNGEVWSVSWNLTGTILSSAGDDGKVRLWKATYS 338 Score = 30.7 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 15/90 (16%), Positives = 32/90 (35%), Gaps = 7/90 (7%) Query: 102 NWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHP 161 N D + A S+ T + Q +++ D + ++ +W N + Sbjct: 264 NMFDNSADVDMDAQGRSDSNTEEKAELQSNLQVELLSEHDDHNGEVWSVSW----NLTGT 319 Query: 162 LLAVAGSRGIIRIINP---ITMQCIKHYVG 188 +L+ AG G +R+ +C+ Sbjct: 320 ILSSAGDDGKVRLWKATYSNEFKCMSVITA 349 Score = 28.7 bits (62), Expect = 5.7, Method: Composition-based stats. Identities = 8/50 (16%), Positives = 20/50 (40%), Gaps = 4/50 (8%) Query: 90 EDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYV 139 +DHN ++ V +N ++ + +V L++ E + + Sbjct: 303 DDHNGEVWSVSWNLTGT----ILSSAGDDGKVRLWKATYSNEFKCMSVIT 348 >6CB1-s nrPDB Length = 569 Score = 63.0 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 58/316 (18%), Positives = 98/316 (31%), Gaps = 56/316 (17%) Query: 19 KKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKC 78 KK L +EN + D G+ ES N + N P +K K + C Sbjct: 305 KKSNLEVNENGDGDEDGEN-------ESAKNAVKKQVAQ--WNKPSQKQLEKDICITISC 355 Query: 79 KYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSY 138 K + K + H + + V S G+ V S +T Q + + Sbjct: 356 KKTVKKL----SWHRKGDYFVTVQPDS--GNTSVLIHQVSKHLT------QSPFKKSKGI 403 Query: 139 VDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKF 198 + F P L V R +RI + +K + ++++ Sbjct: 404 IMDAKFHPF------------KPQLFVCSQRY-VRIYDLSQQILVKKLLPGARWLSKIDI 450 Query: 199 HPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDH 258 HPR NL+ S S D + LW+ D + + H V S ++ S D Sbjct: 451 HPRGDNLIAS-SFDKRV-LWH-DLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDG 507 Query: 259 SLKLWRINSKRMMNAIKESYDYNP-NKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLG- 316 ++ + + + NP + K+ I+ V W Sbjct: 508 TIHV-------FHATVYDDMMKNPMIVPLKKLTGHKV---------INSLGVLDAIWHPR 551 Query: 317 -DLILSKSCENAIVCW 331 + S +N W Sbjct: 552 EAWLFSAGADNTARLW 567 Score = 51.9 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 46/299 (15%), Positives = 94/299 (31%), Gaps = 46/299 (15%) Query: 176 NPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV---AIFGGV 232 P ++C Y GH + L P L + S D +R+W I T V + Sbjct: 185 RPFPIRCSTIYAGHKGKVRTLSIDPS-GLWLATGSDDGTVRVWEILTGREVYRTTLIDDE 243 Query: 233 EGHRDEVLSADYDLL-GEKIMSCGMDHSLKL-------WRINSKRMMNAIKESYDYNPNK 284 E + +++ I++ + ++ L + I + I++ + Y+ Sbjct: 244 ENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTK-IEDGFGYDTFG 302 Query: 285 TNRPFISQKIHFPDFSTRDIHRNYVDCVR-----WL--------GDLILSKSCENAIVCW 331 T + + D + + + V+ W D+ ++ SC+ + Sbjct: 303 TVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKL 362 Query: 332 KPGKMEDDIDKIKPSESNVTILGR----------FDYSQCDIWYMRFSMDFWQKMLALGN 381 + D ++P N ++L F S+ I +F Q + Sbjct: 363 SWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ- 421 Query: 382 QVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL 440 + ++DL L + + + LIA D + W L Sbjct: 422 --RYVRIYDLS---QQILVKKLLPGARW---LSKIDIHPRGDNLIASSFDKRV-LWHDL 471 >5MC6-j nrPDB Length = 397 Score = 63.0 bits (151), Expect = 2e-10, Method: Composition-based stats. Identities = 27/138 (19%), Positives = 55/138 (39%), Gaps = 20/138 (14%) Query: 162 LLAVAGSRGIIRIINPITMQCIKHYVG-HG-----NAINELKFHPRDPNLLLSVSKDHA- 214 L+A + G ++I T++ + ++ H N+I +KF P+ +LL ++ Sbjct: 199 LIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQ-GSLLAIAHDSNSF 257 Query: 215 --LRLWNIQTDTLVAIFG----------GVEGHRDEVLSADYDLLGEKIMSCGMDHSLKL 262 + L+ + + G H V+S ++ GE + S G D L+ Sbjct: 258 GCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCSAGWDGKLRF 317 Query: 263 WRINSKRMMNAIKESYDY 280 W + +K + + D Sbjct: 318 WDVKTKERITTLNMHCDD 335 Score = 35.7 bits (80), Expect = 0.047, Method: Composition-based stats. Identities = 45/310 (14%), Positives = 95/310 (30%), Gaps = 61/310 (19%) Query: 187 VGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQ-------TDTLVAIFGGVEG--HRD 237 H I + + +S S D L++W+ + D + F G H D Sbjct: 13 KAHDADIFSVS---ACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKSGLHHVD 69 Query: 238 EVLSADYDL-LGEKIMSCGMDHSLKLWRIN----SKRMMNAIKESYDYNPNKT------- 285 + + + D + + L +RI +K+++ + D + K Sbjct: 70 VLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHSFWALKW 129 Query: 286 ---NRPFISQKIHFPDFSTR----DIHR----NYVDCVRWLGDLILSKSCEN-------- 326 N +S ++ D H + + W L L + E+ Sbjct: 130 GASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPMTPSQFA 189 Query: 327 -AIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQC---------DIWYMRFSMDFWQKM 376 ++ + G + + S ++ L + I ++FS Sbjct: 190 TSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLA 249 Query: 377 LAL-GNQVGKLYVWDLE-------VEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAV 428 +A N G + +++ E + P + +L + + SF+ L + Sbjct: 250 IAHDSNSFGCITLYETEFGERIGSLSVPTHSSQASLGEFAHSSWVMSLSFNDSGETLCSA 309 Query: 429 CDDASIWRWD 438 D + WD Sbjct: 310 GWDGKLRFWD 319 Score = 33.8 bits (75), Expect = 0.15, Method: Composition-based stats. Identities = 24/131 (18%), Positives = 42/131 (32%), Gaps = 13/131 (9%) Query: 275 KESYDYNPNKTNRPFISQKIHFPDFSTRDIHR-----NYVDCVRWL--GDLILSKSCENA 327 + N P ++ H N + V++ G L+ N+ Sbjct: 197 RGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSPQGSLLAIAHDSNS 256 Query: 328 ---IVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVG 384 I ++ E P+ S+ LG F W M S + + L G Sbjct: 257 FGCITLYETEFGERIGSLSVPTHSSQASLGEF---AHSSWVMSLSFNDSGETLCSAGWDG 313 Query: 385 KLYVWDLEVED 395 KL WD++ ++ Sbjct: 314 KLRFWDVKTKE 324 Score = 33.8 bits (75), Expect = 0.16, Method: Composition-based stats. Identities = 35/253 (13%), Positives = 69/253 (27%), Gaps = 47/253 (18%) Query: 226 VAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRIN------------------- 266 +A + H ++ S +SC D LK+W Sbjct: 6 IATANAGKAHDADIFSV--SACNSFTVSCSGDGYLKVWDNKLLDNENPKDKSYSHFVHKS 63 Query: 267 ----------------SKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDI----HR 306 ++ S D + R ++K+ F D H Sbjct: 64 GLHHVDVLQAIERDAFELCLVATTSFSGDLLFYRITREDETKKVIFEKLDLLDSDMKKHS 123 Query: 307 NY-----VDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIK-PSESNVTILGRFDYSQ 360 + R L +++ + WK D+ + + + + G + Sbjct: 124 FWALKWGASNDRLLSHRLVATDVKGTTYIWKFHPFADESNSLTLNWSPTLELQGTVESPM 183 Query: 361 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR 420 + + ++A G G + + +L P + + +IR FS Sbjct: 184 TPSQFATSVDISERGLIATGFNNGTVQISELSTLRPLYNFESQHSMINNSNSIRSVKFSP 243 Query: 421 DSSILIAVCDDAS 433 S+L D S Sbjct: 244 QGSLLAIAHDSNS 256 >6CHG-D nrPDB Length = 439 Score = 63.0 bits (151), Expect = 3e-10, Method: Composition-based stats. Identities = 45/284 (15%), Positives = 85/284 (29%), Gaps = 49/284 (17%) Query: 195 ELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEG-HRDEVLSADYDLLGEKIMS 253 +KF PR L + S A+ ++++ + +A+ G G H V S + G + S Sbjct: 32 CVKFSPRGDYLAVGCSN-GAIIIYDMDSLKPIAMLGTHSGAHTRSVQSVCWSNDGRYLWS 90 Query: 254 CGMDHSLKLWRINS-----------------------KRMMNAIKESYDYNPNKTNRP-- 288 G D KLW + ++ ++E Y T+R Sbjct: 91 SGRDWYAKLWDMTQPTKCFQQYKFDGPLWSCHVVRWNVCIVTVVEEPTAYVLTLTDRQNA 150 Query: 289 FISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSES 348 F + D V C + I+ W +D E Sbjct: 151 FHCFPLLEQDQDISGHGYTLVACPHPTIESIIITGTSKG---WINAF---QLDLESGFED 204 Query: 349 NVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLT--- 405 + + +I + S +A+ + + L VED ++ + Sbjct: 205 KIRCCYEEKIANANIKQIIISPS--GTRIAINGSDRTIRQYQLIVEDNESEGGSSHSVSI 262 Query: 406 --HHKCGAAIRQTSF------SRDSSILIA---VCDDASIWRWD 438 HK I + + + L+A ++ W+ Sbjct: 263 ELEHKYQDIINRLQWNTIFFSNHSGEYLVASAHGSSAHDLYLWE 306 >6F1U-h nrPDB Length = 612 Score = 62.6 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 45/339 (13%), Positives = 101/339 (29%), Gaps = 77/339 (22%) Query: 72 KWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGE 131 K+K +Y F C + F LV S ++ L++ S Sbjct: 293 KYKKTTPEYVFHC--------QSAVMSATFAKFHPN---LVVGGTYSGQIVLWDNRSNKR 341 Query: 132 IRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGN 191 + ++ + A A + C + +H L + G I + + H Sbjct: 342 TPVQRTPLSAAAHTHPVYCVNVVGTQNAH-NLISISTDGKICSWSL-------DMLSHPQ 393 Query: 192 A-------------INELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDE 238 + + F D N + S++ ++ + + I EGH+ Sbjct: 394 DSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYT-ACRHGSKAGISEMFEGHQGP 452 Query: 239 VLSADYDLL------GEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQ 292 + ++ D ++KLW + + + + +++ Y Sbjct: 453 ITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWSTKNNKPLYSFEDNAGY------------ 500 Query: 293 KIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTI 352 D H CV +G L W +++ V Sbjct: 501 ---VYDVMWSPTHPALFACVDGMGRL----------DLWN-----------LNNDTEVPT 536 Query: 353 LGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDL 391 + +R++ + +A+G+ G++ ++D+ Sbjct: 537 ASISVEGNPALNRVRWT--HSGREIAVGDSEGQIVIYDV 573 >6C0F-s nrPDB Length = 807 Score = 62.6 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 58/316 (18%), Positives = 98/316 (31%), Gaps = 56/316 (17%) Query: 19 KKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKC 78 KK L +EN + D G+ ES N + N P +K K + C Sbjct: 543 KKSNLEVNENGDGDEDGEN-------ESAKNAVKKQVAQ--WNKPSQKQLEKDICITISC 593 Query: 79 KYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSY 138 K + K + H + + V S G+ V S +T Q + + Sbjct: 594 KKTVKKL----SWHRKGDYFVTVQPDS--GNTSVLIHQVSKHLT------QSPFKKSKGI 641 Query: 139 VDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKF 198 + F P L V R +RI + +K + ++++ Sbjct: 642 IMDAKFHPF------------KPQLFVCSQRY-VRIYDLSQQILVKKLLPGARWLSKIDI 688 Query: 199 HPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDH 258 HPR NL+ S S D + LW+ D + + H V S ++ S D Sbjct: 689 HPRGDNLIAS-SFDKRV-LWH-DLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDG 745 Query: 259 SLKLWRINSKRMMNAIKESYDYNP-NKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLG- 316 ++ + + + NP + K+ I+ V W Sbjct: 746 TIHV-------FHATVYDDMMKNPMIVPLKKLTGHKV---------INSLGVLDAIWHPR 789 Query: 317 -DLILSKSCENAIVCW 331 + S +N W Sbjct: 790 EAWLFSAGADNTARLW 805 Score = 51.5 bits (121), Expect = 6e-07, Method: Composition-based stats. Identities = 46/299 (15%), Positives = 94/299 (31%), Gaps = 46/299 (15%) Query: 176 NPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV---AIFGGV 232 P ++C Y GH + L P L + S D +R+W I T V + Sbjct: 423 RPFPIRCSTIYAGHKGKVRTLSIDPS-GLWLATGSDDGTVRVWEILTGREVYRTTLIDDE 481 Query: 233 EGHRDEVLSADYDLL-GEKIMSCGMDHSLKL-------WRINSKRMMNAIKESYDYNPNK 284 E + +++ I++ + ++ L + I + I++ + Y+ Sbjct: 482 ENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTK-IEDGFGYDTFG 540 Query: 285 TNRPFISQKIHFPDFSTRDIHRNYVDCVR-----WL--------GDLILSKSCENAIVCW 331 T + + D + + + V+ W D+ ++ SC+ + Sbjct: 541 TVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKL 600 Query: 332 KPGKMEDDIDKIKPSESNVTILGR----------FDYSQCDIWYMRFSMDFWQKMLALGN 381 + D ++P N ++L F S+ I +F Q + Sbjct: 601 SWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ- 659 Query: 382 QVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL 440 + ++DL L + + + LIA D + W L Sbjct: 660 --RYVRIYDLS---QQILVKKLLPGARW---LSKIDIHPRGDNLIASSFDKRV-LWHDL 709 >6EM1-m nrPDB Length = 807 Score = 62.3 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 58/316 (18%), Positives = 98/316 (31%), Gaps = 56/316 (17%) Query: 19 KKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKC 78 KK L +EN + D G+ ES N + N P +K K + C Sbjct: 543 KKSNLEVNENGDGDEDGEN-------ESAKNAVKKQVAQ--WNKPSQKQLEKDICITISC 593 Query: 79 KYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSY 138 K + K + H + + V S G+ V S +T Q + + Sbjct: 594 KKTVKKL----SWHRKGDYFVTVQPDS--GNTSVLIHQVSKHLT------QSPFKKSKGI 641 Query: 139 VDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKF 198 + F P L V R +RI + +K + ++++ Sbjct: 642 IMDAKFHPF------------KPQLFVCSQRY-VRIYDLSQQILVKKLLPGARWLSKIDI 688 Query: 199 HPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDH 258 HPR NL+ S S D + LW+ D + + H V S ++ S D Sbjct: 689 HPRGDNLIAS-SFDKRV-LWH-DLDLASTPYKTLRYHEKAVRSVNFHKKLPLFSSAADDG 745 Query: 259 SLKLWRINSKRMMNAIKESYDYNP-NKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLG- 316 ++ + + + NP + K+ I+ V W Sbjct: 746 TIHV-------FHATVYDDMMKNPMIVPLKKLTGHKV---------INSLGVLDAIWHPR 789 Query: 317 -DLILSKSCENAIVCW 331 + S +N W Sbjct: 790 EAWLFSAGADNTARLW 805 Score = 51.5 bits (121), Expect = 8e-07, Method: Composition-based stats. Identities = 46/299 (15%), Positives = 94/299 (31%), Gaps = 46/299 (15%) Query: 176 NPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV---AIFGGV 232 P ++C Y GH + L P L + S D +R+W I T V + Sbjct: 423 RPFPIRCSTIYAGHKGKVRTLSIDPS-GLWLATGSDDGTVRVWEILTGREVYRTTLIDDE 481 Query: 233 EGHRDEVLSADYDLL-GEKIMSCGMDHSLKL-------WRINSKRMMNAIKESYDYNPNK 284 E + +++ I++ + ++ L + I + I++ + Y+ Sbjct: 482 ENPDYHIECIEWNPDANNGILAVAVGENIHLIVPPIFGYDIENNGKTK-IEDGFGYDTFG 540 Query: 285 TNRPFISQKIHFPDFSTRDIHRNYVDCVR-----WL--------GDLILSKSCENAIVCW 331 T + + D + + + V+ W D+ ++ SC+ + Sbjct: 541 TVKKSNLEVNENGDGDEDGENESAKNAVKKQVAQWNKPSQKQLEKDICITISCKKTVKKL 600 Query: 332 KPGKMEDDIDKIKPSESNVTILGR----------FDYSQCDIWYMRFSMDFWQKMLALGN 381 + D ++P N ++L F S+ I +F Q + Sbjct: 601 SWHRKGDYFVTVQPDSGNTSVLIHQVSKHLTQSPFKKSKGIIMDAKFHPFKPQLFVCSQ- 659 Query: 382 QVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL 440 + ++DL L + + + LIA D + W L Sbjct: 660 --RYVRIYDLS---QQILVKKLLPGARW---LSKIDIHPRGDNLIASSFDKRV-LWHDL 709 >6E29-D nrPDB Length = 345 Score = 62.3 bits (149), Expect = 4e-10, Method: Composition-based stats. Identities = 42/295 (14%), Positives = 84/295 (28%), Gaps = 39/295 (13%) Query: 157 NTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALR 216 N LA G + I + TM + GH I L + R LLS + + Sbjct: 34 NRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWS-RCGRYLLSACQGWKVI 92 Query: 217 LWNIQTDTLVAIFGGVEGHRDEVLSADYDL-LGEKIMSCGMDHSLKLWRINSKRMMNAIK 275 LW++Q R V A+ + + + L I Sbjct: 93 LWDLQDGKRYREVRF----RAPVYGAELHPWNHHQFAAALFEDQPMLVDI------TEPV 142 Query: 276 ESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRW--LGDLILSKSCENAIVCWKP 333 E P+ R + ++ ++ + + GD +L+ + + + Sbjct: 143 EVRYVLPSVPKRTSTETDPALREKQAKEDAKHMTTAIVYTASGDHLLAGTTKGRLNIIDA 202 Query: 334 GKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVW---- 389 E I+ + I +R + + L + Q + + Sbjct: 203 RTRE--------------IIYSEKIASGIITTLRLTES--GRELLVNAQDRIIRTFIVPN 246 Query: 390 ----DLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDA-SIWRWDR 439 DL+ + + +FS + A + ++ W+R Sbjct: 247 LSAADLDPDTIQLPLEHKFQDVVNRLSWNHVAFSATGEYVAASTYNNHELYIWER 301 Score = 42.2 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 18/84 (21%), Positives = 27/84 (32%), Gaps = 6/84 (7%) Query: 355 RFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIR 414 + + LA G G + +WDLE + L H I Sbjct: 18 NITNTIRSGHSTCVRFNRKGDFLASGRVDGTVVIWDLETMGVAR----KLRGHSK--NIT 71 Query: 415 QTSFSRDSSILIAVCDDASIWRWD 438 S+SR L++ C + WD Sbjct: 72 SLSWSRCGRYLLSACQGWKVILWD 95 Score = 39.5 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 9/62 (14%), Positives = 26/62 (41%), Gaps = 7/62 (11%) Query: 234 GHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS----KRMMNAIKESYDYNPNKTNRPF 289 GH ++ G+ + S +D ++ +W + + +++ K + ++ R Sbjct: 26 GHS---TCVRFNRKGDFLASGRVDGTVVIWDLETMGVARKLRGHSKNITSLSWSRCGRYL 82 Query: 290 IS 291 +S Sbjct: 83 LS 84 Score = 34.5 bits (77), Expect = 0.10, Method: Composition-based stats. Identities = 14/74 (18%), Positives = 32/74 (43%), Gaps = 4/74 (5%) Query: 194 NELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMS 253 N + F + S +H L +W +LV + +EG ++E ++ + + Sbjct: 275 NHVAFSATGEYVAASTYNNHELYIWERGHGSLVRM---LEGPKEEQGVIEWHPHRALLAA 331 Query: 254 CGMD-HSLKLWRIN 266 CG++ + +W + Sbjct: 332 CGLETGRINIWSVT 345 >5WLC-LW nrPDB Length = 554 Score = 60.7 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 40/207 (19%), Positives = 72/207 (34%), Gaps = 22/207 (10%) Query: 112 VFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGI 171 FA +Y+ H E+ L+ +++A + H LL AG G Sbjct: 165 YFAVAQKKYTFIYD-HEGTELHRLKQHIEARHLDFLPY----------HYLLVTAGETGW 213 Query: 172 IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGG 231 ++ + T Q + + +P + + L S + LW+ + Sbjct: 214 LKYHDVSTGQLVSELRTKAGPTMAMAQNPWNAVMHLGHSN-GTVSLWSPSMPEPLVKLLS 272 Query: 232 VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFIS 291 G V S D G + + G D S+K+W I + + ++ S + P IS Sbjct: 273 ARG---PVNSIAIDRSGYYMATTGADRSMKIWDIRNFKQLH----SVESLPTPGTNVSIS 325 Query: 292 QKIHFPDFSTRDIH-RNYVDCVRWLGD 317 +R H + D ++ GD Sbjct: 326 DTGLLA--LSRGPHVTLWKDALKLSGD 350 >5YZG-2 nrPDB Length = 646 Score = 60.3 bits (144), Expect = 1e-09, Method: Composition-based stats. Identities = 36/249 (14%), Positives = 76/249 (30%), Gaps = 26/249 (10%) Query: 189 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLG 248 H + I + D +++ S D ++ W + + + H + S G Sbjct: 89 HRDVITHVVCTKTD--FIITASHDGHVKFWK-KIEEGIEFVKHFRSHLGVIESIAVSSEG 145 Query: 249 EKIMSCGMDHSLKLWRINSKRMMNAIKESY-------DYNPNKTNRPFISQKIHFPDFST 301 S G D ++K++ + + M+N +K Y Y P + + Sbjct: 146 ALFCSVGDDKAMKVFDVVNFDMINMLKLGYFPGQCEWIYCPGDAISSVAASEKSTGKIFI 205 Query: 302 RDI-------------HRNYVDCVRWLGDLILSKSCENA--IVCWKPGKMEDDIDKIKPS 346 D H + + +R S + + I W E K Sbjct: 206 YDGRGDNQPLHIFDKLHTSPLTQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVNW 265 Query: 347 ESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTH 406 E T +++++C + K +A K+ ++ + +L+ Sbjct: 266 EYK-TDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVTGKLMRVFDESLSM 324 Query: 407 HKCGAAIRQ 415 +RQ Sbjct: 325 FTELQQMRQ 333 Score = 50.7 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 39/226 (17%), Positives = 80/226 (35%), Gaps = 33/226 (14%) Query: 109 DPLVFATVGSNR-VTLYECHSQGEIRLLQSYVDADADENFYTCAWTY-DSNTSHPLLAVA 166 + +F +VG ++ + +++ + I +L+ C W Y + + A Sbjct: 144 EGALFCSVGDDKAMKVFDVVNFDMINMLK------LGYFPGQCEWIYCPGDAISSVAASE 197 Query: 167 GSRGIIRIINPI-TMQCIKHY-VGHGNAINELKFHPRDPNLLLSVSKDHALRL------- 217 S G I I + Q + + H + + +++ +P VS D + + Sbjct: 198 KSTGKIFIYDGRGDNQPLHIFDKLHTSPLTQIRLNPV---YKAVVSSDKSGMIEYWTGPP 254 Query: 218 ----------WNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 267 W +TDT + F + + V + G+KI + G D ++++R + Sbjct: 255 HEYKFPKNVNWEYKTDTDLYEFAKCKAYPTSVC---FSPDGKKIATIGSDRKVRIFRFVT 311 Query: 268 KRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVR 313 ++M ES + F + VD VR Sbjct: 312 GKLMRVFDESLSMFTELQQMRQQLPDMEFGRRMAVERELEKVDAVR 357 Score = 36.4 bits (82), Expect = 0.024, Method: Composition-based stats. Identities = 34/263 (12%), Positives = 67/263 (25%), Gaps = 74/263 (28%) Query: 220 IQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYD 279 + +++ HRD + I++ D +K W+ Sbjct: 74 LDNLPSASMYERSYMHRDVITHVVCTKTD-FIITASHDGHVKFWK--------------- 117 Query: 280 YNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWK----- 332 I HF H ++ + G L S + A+ + Sbjct: 118 -----KIEEGIEFVKHF------RSHLGVIESIAVSSEGALFCSVGDDKAMKVFDVVNFD 166 Query: 333 ----------PGKME------DDIDKIKPSESNVTILGRFDY-----------SQCDIWY 365 PG+ E D I + SE + + +D Sbjct: 167 MINMLKLGYFPGQCEWIYCPGDAISSVAASEKSTGKIFIYDGRGDNQPLHIFDKLHTSPL 226 Query: 366 MRFSMDFWQKMLALGNQVGKLYVW-----------DLEVEDPHKAKCTTLTHHKCGAAIR 414 + ++ K + ++ G + W ++ E KC A Sbjct: 227 TQIRLNPVYKAVVSSDKSGMIEYWTGPPHEYKFPKNVNWEYKTDTDLYEFA--KCKAYPT 284 Query: 415 QTSFSRDSSILIAVCDDASIWRW 437 FS D + + D + + Sbjct: 285 SVCFSPDGKKIATIGSDRKVRIF 307 >5LTD-A nrPDB Length = 525 Score = 58.0 bits (138), Expect = 8e-09, Method: Composition-based stats. Identities = 22/140 (15%), Positives = 51/140 (36%), Gaps = 4/140 (2%) Query: 170 GIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHAL-RLWNIQTDTLVAI 228 G + I + T+Q H ++ + +D LL + S + R++++ T + Sbjct: 202 GDVIIFDAKTLQPTSVIEAHRTSLAAIALS-KDGLLLATASDKGTIIRVFSVATGIKLYQ 260 Query: 229 FGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRP 288 F + S + +++ ++ ++R+ + N IK S + T Sbjct: 261 FRRGTYPTK-IYSLAFSPDNRFVIASSATETVHIFRLGEEEAANTIK-SANKKARLTKAQ 318 Query: 289 FISQKIHFPDFSTRDIHRNY 308 + PD + H + Sbjct: 319 VPNPLETSPDIYPHNQHTSS 338 >2P9P-C nrPDB Length = 372 Score = 57.6 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 38/282 (13%), Positives = 80/282 (28%), Gaps = 40/282 (14%) Query: 157 NTSHPLLAVAGSRGIIRIINPITMQ--CIKHYVGHGNAINELKFHPRDPNLLLSVSKDHA 214 N +A+ + + I + + H + + + P D N +++ D Sbjct: 17 NKDRTQIAICPNNHEVHIYEKSGNKWVQVHELKEHNGQVTGVDWAP-DSNRIVTCGTDRN 75 Query: 215 LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAI 274 +W ++ T + + +K + + Sbjct: 76 AYVWTLKGRTWKPTLVILR-INRAARCVRWAPNEKKFAVGSGSRVISI--------CYFE 126 Query: 275 KESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPG 334 +E+ + +P S + + D H N V L+ + SC+ + Sbjct: 127 QENDWWVCKHIKKPIRSTVL------SLDWHPNSV--------LLAAGSCDFKCRIFSAY 172 Query: 335 KMEDDIDK-IKPSESNVT---ILGRFDYSQCDIWYMRFSMDFWQKML-------ALGNQV 383 E + P S + ++ S + + FS + + L + Sbjct: 173 IKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSANGSRVAWVSHDSTVCLADAD 232 Query: 384 GKLYVWDLEVEDPHKAKCTTLTHHK---CGAAIRQTSFSRDS 422 K+ V L E T +T G F+ DS Sbjct: 233 KKMAVATLASETLPLLAVTFITESSLVAAGHDCFPVLFTYDS 274 >5WLC-LN nrPDB Length = 776 Score = 55.3 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 54/350 (15%), Positives = 101/350 (28%), Gaps = 46/350 (13%) Query: 115 TVGSNRVTLYECH-SQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIR 173 +VG + T+ S G L + + T AW D + S G IR Sbjct: 157 SVGCDNGTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKD-----DFVIGGCSDGRIR 211 Query: 174 IINPIT-----MQCIKHYV-----GHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTD 223 I + + + + + + PR + + S +++ W+ Q Sbjct: 212 IWSAQKNDENMGRLLHTMKVDKAKKESTLVWSVIYLPRT-DQIASGDSTGSIKFWDFQFA 270 Query: 224 TLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSL-------------KLWRINSKRM 270 TL F + H +VL D + S G+D + W +S R+ Sbjct: 271 TLNQSF---KAHDADVLCLTTDTDNNYVFSAGVDRKIFQFSQNTNKSQKNNRWVNSSNRL 327 Query: 271 M--NAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNY----VDCVRWLGDLILSKSC 324 + N I+ Y + ++ N + V +L Sbjct: 328 LHGNDIRAICAYQSKGADFLVSGGVEKTLVINSLTSFSNGNYRKMPTVEPYSKNVLVNKE 387 Query: 325 ENAIVCWKPGKM---EDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGN 381 + +V W + D + Q +I S D ++ Sbjct: 388 QRLVVSWSESTVKIWTMGTDSSTEQNYKLVCKLTLKDDQ-NISTCSLSPDGQVLVV---G 443 Query: 382 QVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDD 431 + V+ L+ + + F +S I+I C+D Sbjct: 444 RPSTTKVFHLQPVGNKLKVTKLDNDLLLRTSTKLVKFIDNSKIVICSCED 493 Score = 33.4 bits (74), Expect = 0.22, Method: Composition-based stats. Identities = 25/182 (13%), Positives = 55/182 (30%), Gaps = 15/182 (8%) Query: 270 MMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIV 329 A S ++ + + + W ++++ + +I Sbjct: 41 FTPATITSLAFSHKSNINKLTPSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDRSIE 100 Query: 330 --CWKPG-------KMEDDIDKIKPSESNVTI-LGRFDYSQCDIWYMRFSMDFWQKMLAL 379 CW + + + L +D + IW S++ Q L++ Sbjct: 101 GLCWSNVNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIW--SISINDSQDKLSV 158 Query: 380 GNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDR 439 G G + + D+ T L + A + ++ +D +I C D I W Sbjct: 159 GCDNGTVVLIDISGGPGVLEHDTIL--MRQEARVLTLAWKKD-DFVIGGCSDGRIRIWSA 215 Query: 440 LR 441 + Sbjct: 216 QK 217 >5K19-A nrPDB Length = 569 Score = 53.8 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 38/219 (17%), Positives = 65/219 (29%), Gaps = 40/219 (18%) Query: 190 GNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGE 249 A+NE F P D L VS+D LR++N + L G +L + G+ Sbjct: 220 EGALNEFAFSP-DGKFLACVSQDGFLRVFNFDSVELHGTMKSYFG---GLLCVCWSPDGK 275 Query: 250 KIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYV 309 I++ G D + +W R+ + H+++V Sbjct: 276 YIVTGGEDDLVTVWSFVDCRV----------------------------IARGHGHKSWV 307 Query: 310 DCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFS 369 V + S + + + D+ +N T Sbjct: 308 SVVAFDP-YTTSVEEGDPMEFSGSDEDFQDLLHFGRDRANST-----QSRLSKRNSTDSR 361 Query: 370 MDFWQKMLALGNQVGKLYVWDLE--VEDPHKAKCTTLTH 406 Q +L +WDL + PH+ TH Sbjct: 362 PVSVTYRFGSVGQDTQLCLWDLTEDILFPHQPLSRARTH 400 Score = 50.7 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 22/219 (10%), Positives = 60/219 (27%), Gaps = 24/219 (10%) Query: 147 FYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHP------ 200 W+ D + G ++ + + + + I GH + ++ + F P Sbjct: 265 LLCVCWSPDG----KYIVTGGEDDLVTVWSFVDCRVIARGHGHKSWVSVVAFDPYTTSVE 320 Query: 201 RDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSL 260 + S S + L + D + + + + + S G D L Sbjct: 321 EGDPMEFSGSDEDFQDLLHFGRDRANSTQSRLSKRNST--DSRPVSVTYRFGSVGQDTQL 378 Query: 261 KLWRI------------NSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNY 308 LW + ++ N + + + N P + + Sbjct: 379 CLWDLTEDILFPHQPLSRARTHTNVMNATSPPAGSNGNSVTTPGNSVPPPLPRSNSLPHS 438 Query: 309 VDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSE 347 ++ + + + + + D ++ + Sbjct: 439 AVSNAGSKSSVMDGAIASGVSKFATLSLHDRKERHHEKD 477 Score = 42.6 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 16/78 (20%), Positives = 29/78 (37%), Gaps = 8/78 (10%) Query: 360 QCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFS 419 + + FS D K LA +Q G L V++ + + H + C +S Sbjct: 220 EGALNEFAFSPD--GKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLC------VCWS 271 Query: 420 RDSSILIAVCDDASIWRW 437 D ++ +D + W Sbjct: 272 PDGKYIVTGGEDDLVTVW 289 >5M89-A nrPDB Length = 329 Score = 51.9 bits (122), Expect = 6e-07, Method: Composition-based stats. Identities = 34/164 (20%), Positives = 67/164 (40%), Gaps = 17/164 (10%) Query: 92 HNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCA 151 H P+ G+ + + + A+VG ++ ++ GE R+ + Y AD TCA Sbjct: 129 HAGPVTGLAVHPGGR-----ILASVGVDKSFVFYDLETGE-RVARGY----ADAALTTCA 178 Query: 152 WTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSK 211 + D N L A G I + + T++ + + G I L F + Sbjct: 179 FHPDGN----LFAAGTQTGHILVFHTTTLEQAESFPL-GTPIQALAFSENGFWFAATGKG 233 Query: 212 DHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCG 255 ++ +++++ A ++ EVLS +D G+ + + G Sbjct: 234 TSSVTIFDLRKSGAAAAVKELQ--TGEVLSISWDYTGQYLATGG 275 Score = 41.5 bits (95), Expect = 8e-04, Method: Composition-based stats. Identities = 24/228 (10%), Positives = 62/228 (27%), Gaps = 19/228 (8%) Query: 164 AVAGSRGIIRIINPITMQCIKHY-VGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQT 222 AV G G + I + + + + +G + ++ ++ + +++++ Sbjct: 67 AVGGLDGKLDIYSVVANKVERTLDIG--EPVTATEW---TGTKVVIGTAKGWVKVYDAGR 121 Query: 223 DTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNP 282 ++ + H V G + S G+D S + + + + Sbjct: 122 ES-----ATFQTHAGPVTGLAVHPGGRILASVGVDKSFVFYDLETGERVARGYADAALTT 176 Query: 283 NKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDK 342 + H ++ + A+ + G K Sbjct: 177 CAFHPDGNLFAAGTQTGHILVFHTTTLEQAESFP----LGTPIQALAFSENGFWFAATGK 232 Query: 343 IKPSESNVTILGRFDYS----QCDIWYMRFSMDFWQKMLALGNQVGKL 386 S + + + + S D+ + LA G G Sbjct: 233 GTSSVTIFDLRKSGAAAAVKELQTGEVLSISWDYTGQYLATGGGTGVT 280 >5TF2-A nrPDB Length = 407 Score = 51.9 bits (122), Expect = 6e-07, Method: Composition-based stats. Identities = 19/74 (25%), Positives = 33/74 (44%), Gaps = 4/74 (5%) Query: 157 NTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALR 216 N + LLA G+ G +R+ +++ + + H I +L P L++V +D Sbjct: 181 NHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDG--KLVTVGRDLKAS 238 Query: 217 LWNIQTDTLVAIFG 230 +W Q D LV Sbjct: 239 VW--QKDQLVTQLH 250 Score = 43.0 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 17/109 (15%), Positives = 38/109 (34%), Gaps = 4/109 (3%) Query: 190 GNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGE 249 + + ++ D LL + D +R+W + + + H E+ G Sbjct: 171 SDPLQKVVCFNHDNTLLATGGTDGYVRVWKV---PSLEKVLEFKAHEGEIEDLALGPDG- 226 Query: 250 KIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPD 298 K+++ G D +W+ + +E+ + R + PD Sbjct: 227 KLVTVGRDLKASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPD 275 Score = 34.1 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 27/71 (38%), Gaps = 7/71 (9%) Query: 371 DFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAV-C 429 + +LA G G + VW + P K H+ I + D ++ Sbjct: 181 NHDNTLLATGGTDGYVRVW----KVPSLEKVLEFKAHE--GEIEDLALGPDGKLVTVGRD 234 Query: 430 DDASIWRWDRL 440 AS+W+ D+L Sbjct: 235 LKASVWQKDQL 245 >6CVZ-A nrPDB Length = 351 Score = 51.5 bits (121), Expect = 8e-07, Method: Composition-based stats. Identities = 48/275 (17%), Positives = 95/275 (34%), Gaps = 29/275 (10%) Query: 172 IRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGG 231 +++++ M+ ++ HG I L F LLLS S D+ ++L +++T+T+V + Sbjct: 56 VKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSLETNTVVQTYNA 115 Query: 232 VEGHRDEVLSADYDLLG-EKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFI 290 V S + L I + + S+ ++ + N + + + Sbjct: 116 GR----PVWSCCWCLDEANYIYAGLANGSILVYDVR--------------NTSSHVQELV 157 Query: 291 SQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNV 350 +QK P S + R + G +L+ + E+A W+ + P E Sbjct: 158 AQKARCPLVSLSYMPRAASAAFPYGG--VLAGTLEDA-SFWEQKMDFSHWPHVLPLEPGG 214 Query: 351 TILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDL-EVEDPHKAKCTTLTHHKC 409 I + + S + + D + + D + T C Sbjct: 215 CIDFQTENSSRHCL-VTYRPDKNHTTIRSVLMEMSYRLDDTGNPICSCQPVHTFFGGPTC 273 Query: 410 GAAIRQTSFSR---DSSILIAVCDD--ASIWRWDR 439 + F D +IL+ D+ S WD Sbjct: 274 KLLTKNAIFQSPENDGNILVCTGDEAANSALLWDA 308 >3EI3-B nrPDB Length = 383 Score = 50.3 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 13/75 (17%), Positives = 34/75 (45%), Gaps = 1/75 (1%) Query: 189 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDL-L 247 H + +F+PR L+ + S D ++LW+++ + H V +A ++ Sbjct: 203 HKAKVTHAEFNPRCDWLMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTD 262 Query: 248 GEKIMSCGMDHSLKL 262 K+++ + +++ Sbjct: 263 STKLLTTDQRNEIRV 277 Score = 46.8 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 20/168 (11%), Positives = 60/168 (35%), Gaps = 26/168 (15%) Query: 143 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVG---HGNAINELKFH 199 E C W L+A + +++ + ++ Y+ H +N F+ Sbjct: 209 HAEFNPRCDW---------LMATSSVDATVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFN 259 Query: 200 PRDPNLLLSVSKDHALRL---WNIQTDTLVAIFGGVEG-HRDEVLSADYDLLGEKIMSCG 255 P D LL+ + + +R+ ++ + I + H + + + + + I++ Sbjct: 260 PTDSTKLLTTDQRNEIRVYSSYDWSKPDQIIIHPHRQFQHLTPIKA-TWHPMYDLIVAGR 318 Query: 256 M---------DHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKI 294 ++ ++ NS +++ +++ N+ + + Sbjct: 319 YPDDQLLLNDKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSPTGDV 366 Score = 43.4 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 41/266 (15%), Positives = 78/266 (29%), Gaps = 54/266 (20%) Query: 181 QCIKHYVGHGNA------INELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEG 234 + +K Y H A + L++HP P + SK + LW+ + G+ G Sbjct: 58 RSLKSYKLHRTASPFDRRVTSLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGM-G 116 Query: 235 HRDEVLSADYDL--LGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQ 292 D + ++ + +S T R F Sbjct: 117 PGDAITGMKFNQFNTNQLFVSS-------------------------IRGATTLRDFSGS 151 Query: 293 KIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTI 352 I F+ D + CV + + ++ G +I K K ++ VT Sbjct: 152 VIQV--FAKTDSWDYWYCCVDVSVSRQMLATGDSTGRLLLLGLDGHEIFKEKLHKAKVT- 208 Query: 353 LGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAA 412 + ++A + + +WDL + + H K Sbjct: 209 ------HAEFNPRCDW-------LMATSSVDATVKLWDLRNIKDKNSYIAEMPHEK---P 252 Query: 413 IRQTSFSR-DSSILIAVCDDASIWRW 437 + F+ DS+ L+ I + Sbjct: 253 VNAAYFNPTDSTKLLTTDQRNEIRVY 278 >3I2N-A nrPDB Length = 357 Score = 47.2 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 41/313 (13%), Positives = 90/313 (28%), Gaps = 46/313 (14%) Query: 138 YVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM--QCIKHYVGHGNAINE 195 ++ + + C W S + A G+I++ + ++ I Sbjct: 12 HIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLREIEK-AKPIKC 70 Query: 196 LKF--HPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL------ 247 F L + L +WN++ V+GH++ + + D Sbjct: 71 GTFGATSLQQRYLATGDFGGNLHIWNLE--APEMPVYSVKGHKEIINAIDGIGGLGIGEG 128 Query: 248 GEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRN 307 +I++ D ++K+W K +P P + Sbjct: 129 APEIVTGSRDGTVKVWDPRQK-----------DDPVANMEPVQGENKRDCWTVAFG---- 173 Query: 308 YVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMR 367 + ++ + I + M + + N FD Sbjct: 174 --NAYNQEERVVCAGYDNGDIKLFDLRNMALRWE---TNIKNGVCSLEFD---------- 218 Query: 368 FSMDFWQKMLALGNQVGKLYVWDLEVEDPHK--AKCTTLTHHKCGAAIRQTSFSRDSSIL 425 D L + GK +V+D+ + P K A + H +R +R+ + Sbjct: 219 -RKDISMNKLVATSLEGKFHVFDMRTQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLT 277 Query: 426 IAVCDDASIWRWD 438 +W+++ Sbjct: 278 AGGAGGLHLWKYE 290 Score = 41.5 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 31/230 (13%), Positives = 75/230 (32%), Gaps = 18/230 (7%) Query: 109 DPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGS 168 P + V +++ + + V + + +T A+ N ++ Sbjct: 129 APEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEERVVCAGYD 188 Query: 169 RGIIRIINPITMQCIKHYVGHGNAINELKFHPRD--PNLLLSVSKDHALRLWNIQTDTLV 226 G I++ + M ++ N + L+F +D N L++ S + +++++T Sbjct: 189 NGDIKLFDLRNM-ALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFDMRTQHPT 247 Query: 227 AIFGGV--EGHRDEVLSADYDLLG-EKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPN 283 F V + H+ V + E ++ G L LW+ + Sbjct: 248 KGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWK-------YEYPIQRSKKDS 300 Query: 284 KTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGD---LILSKSCENAIVC 330 + ++ + T + + W D L + S + + Sbjct: 301 EGIEMGVAGSVSLLQNVTLSTQP--ISSLDWSPDKRGLCVCSSFDQTVRV 348 >3JB9-S nrPDB Length = 488 Score = 47.2 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 14/98 (14%), Positives = 38/98 (38%), Gaps = 4/98 (4%) Query: 157 NTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALR 216 + L G +R + + + H + + L+F L+++ + D + Sbjct: 342 HPDGNLFVAGLENGELRFFETSSGNELTKFGPHSSPVKTLQFGENGYWLVVTTNDDSDIF 401 Query: 217 LWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSC 254 +W+++ LV + +V + D+ + ++S Sbjct: 402 IWDLRKSELVQKIPL----QTKVAAVSLDITSQLLVSS 435 >2VDU-B nrPDB Length = 450 Score = 45.3 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 43/361 (11%), Positives = 111/361 (30%), Gaps = 37/361 (10%) Query: 103 WHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADE---NFYTCAWTYDSNTS 159 G P +++ + + R+T E +S + D D+ N + + Sbjct: 92 PSPGLGAPPIYSYIRNLRLTSDESRLIACADSDKSLLVFDVDKTSKNVLKLRKRFCFSKR 151 Query: 160 HPLLAVAGSRGIIRI-----------INPITMQCIKH--YVGHGNAINELKF--HPRDPN 204 +++A + I IN I + +GH + + ++ Sbjct: 152 PNAISIAEDDTTVIIADKFGDVYSIDINSIPEEKFTQEPILGHVSMLTDVHLIKDSDGHQ 211 Query: 205 LLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 +++ +D +++ + + GH+ V S ++S G D + W Sbjct: 212 FIITSDRDEHIKI--SHYPQCFIVDKWLFGHKHFVSSICCGKD-YLLLSAGGDDKIFAWD 268 Query: 265 INSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSC 324 + + ++ +DYN I ++ + D + + I+ Sbjct: 269 WKTGKNLST----FDYNS------LIKPYLNDQHLAPPRFQNENNDIIEFAVSKIIKSKN 318 Query: 325 ENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQ----KMLALG 380 + + I ++ + L + ++ + D +Q + G Sbjct: 319 LPFVAFFVEATKCIIILEMSEKQKGDLALKQIITFPYNVISLSAHNDEFQVTLDNKESSG 378 Query: 381 NQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL 440 Q + + + ++ A I+ DS+++ + ++ L Sbjct: 379 VQKNFAKFIEYNLNENSFVVNNEKSNEFDSAIIQSV--QGDSNLVTKKEEIYPLYNVSSL 436 Query: 441 R 441 R Sbjct: 437 R 437 >6IYY-A nrPDB Length = 317 Score = 44.5 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 12/110 (10%), Positives = 43/110 (39%), Gaps = 5/110 (4%) Query: 156 SNTSHPLLAVAGSR-GIIRIINPI-TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDH 213 N+++ LLA G+ G +++++ T + H ++ + + + + + S+ Sbjct: 140 PNSNNSLLAFPGTHTGHVQLVDLASTEKPPVDIPAHEGVLSCIALNLQGTR-IATASEKG 198 Query: 214 A-LRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKL 262 +R+++ + L+ + +++ I ++ + Sbjct: 199 TLIRIFDTSSGHLIQELRRGS-QAANIYCINFNQDASLICVSSDHGTVHI 247 >4FHN-A nrPDB Length = 394 Score = 43.8 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 27/201 (13%), Positives = 60/201 (29%), Gaps = 32/201 (15%) Query: 137 SYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINEL 196 + + D + ++ D+ + ++A G + I I + + Sbjct: 135 GHHNFVNDIDIADV-YSADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGISV 193 Query: 197 KFHPRDPNLLLSVSKDHALRLWNIQ--------------TDTLVAIFGGVE--------G 234 +F P +PN L+ ++ +R+++ + + + G Sbjct: 194 QFRPSNPNQLIVGERNGNIRIFDWTLNLSAEENSQTELVKNPWLLTLNTLPLVNTCHSSG 253 Query: 235 HRDEVLSADY-DLLGEKIM----SCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPF 289 + + + G I+ S W + + N I +S K P Sbjct: 254 IASSLANVRWIGSDGSGILAMCKSGAWLR----WNLFANNDYNEISDSTMKLGPKNLLPN 309 Query: 290 ISQKIHFPDFSTRDIHRNYVD 310 + FP H Y+D Sbjct: 310 VQGISLFPSLLGACPHPRYMD 330 Score = 41.1 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 36/192 (18%), Positives = 69/192 (35%), Gaps = 21/192 (10%) Query: 120 RVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSN--TSHPLLAVAGSRGIIRIINP 177 T + S LL D + T S T L + + + Sbjct: 20 YTTTWCSQSPSCSNLLAIGHDTGITIYCASEEQTPGSTGLTLQELFTIQTGLPTLHLSFS 79 Query: 178 ITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV--AIFGGVEGH 235 + ++ +N P L V +D+ +RL + +T++ + GG GH Sbjct: 80 SSCSYSENLHDGDGNVNS---SPVYSLFLACVCQDNTVRLIITKNETIITQHVLGGKSGH 136 Query: 236 RD--------EVLSADYDLLGEKIMSCGMDHSLKLWRIN------SKRMMNAIKESYDYN 281 + +V SAD L + I S G D +L +WR+ + +++ S + Sbjct: 137 HNFVNDIDIADVYSADNRLAEQVIASVGDDCTLIIWRLTDEGPILAGYPLSSPGISVQFR 196 Query: 282 PNKTNRPFISQK 293 P+ N+ + ++ Sbjct: 197 PSNPNQLIVGER 208 >6N8P-A nrPDB Length = 979 Score = 43.4 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 31/187 (16%), Positives = 67/187 (35%), Gaps = 26/187 (13%) Query: 104 HSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQ-----SYVDADADENFYTCAWTYDSNT 158 H G + + N + L+ +G LQ + T ++ Sbjct: 69 HLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHS 128 Query: 159 SHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINE-----------------LKFHPR 201 S LL + G + ++ + ++ +A+ + L+ HPR Sbjct: 129 SCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHPR 188 Query: 202 DPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLK 261 DPN +L + +W++Q ++ F + ++ + + G ++SC D S Sbjct: 189 DPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQ----QLENIWWQRDGRLLVSCHSDGSYC 244 Query: 262 LWRINSK 268 W ++S+ Sbjct: 245 QWPVSSE 251 Score = 36.8 bits (83), Expect = 0.019, Method: Composition-based stats. Identities = 38/255 (14%), Positives = 86/255 (33%), Gaps = 30/255 (11%) Query: 187 VGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDL 246 G + + L + P +L ++ A++L+ F G+ + V Sbjct: 18 HGFPHQPSALGYSPS-LRILAIGTRSGAIKLY----GAPGVEFMGLHQENNAVTQIHLLP 72 Query: 247 LGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN---PNKTNRPFISQKIHFPDFSTRD 303 ++++ D+SL LW + K + ++E + P + P S Sbjct: 73 GQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCEL 132 Query: 304 IHRNYVDCVRWLGDLILSKS-CENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCD 362 ++ ++ L ++ + I D + + P E+ + Sbjct: 133 LYLGTESGNVFVVQLPAFRALEDRTI-------SSDAVLQRLPEEARHRRVFEM------ 179 Query: 363 IWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDS 422 + ++ ++L +G G + +WDL+ L H + + RD Sbjct: 180 VEALQEHPRDPNQIL-IGYSRGLVVIWDLQGSR-------VLYHFLSSQQLENIWWQRDG 231 Query: 423 SILIAVCDDASIWRW 437 +L++ D S +W Sbjct: 232 RLLVSCHSDGSYCQW 246 Score = 34.9 bits (78), Expect = 0.076, Method: Composition-based stats. Identities = 17/91 (18%), Positives = 32/91 (35%), Gaps = 10/91 (10%) Query: 106 KEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADEN--FYTCAWTYDSNTS---- 159 A++ + +T S ++L + + A + +N F T W D TS Sbjct: 361 PPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPA 420 Query: 160 ---HPLLAVAGSRGIIRIINPITMQCIKHYV 187 LL G +R + + C++ Sbjct: 421 PPQRDLLLTGHEDGTVRFWD-ASGVCLRLLY 450 Score = 34.1 bits (76), Expect = 0.12, Method: Composition-based stats. Identities = 10/54 (18%), Positives = 21/54 (38%), Gaps = 1/54 (1%) Query: 194 NELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLL 247 L P +LLL+ +D +R W+ + + + + R + D + Sbjct: 415 TSLTPAPPQRDLLLTGHEDGTVRFWDA-SGVCLRLLYKLSTVRVFLTDTDPNEN 467 >5WLC-LS nrPDB Length = 594 Score = 43.4 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 47/344 (13%), Positives = 99/344 (28%), Gaps = 46/344 (13%) Query: 112 VFATVGSNRVTLYECHSQGEIRL-LQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRG 170 + +T + + TL +L + DA+A ++ + + S PLL G Sbjct: 211 ILSTTYNYKDTLSNSKLLPPKKLDIVRLKDANASHPSHSAIQSLSFHPSKPLLLTGGYDK 270 Query: 171 IIRII--NPITMQCIKHYVGHGNAINELKF----HPRDPNLLLSVSKDHALRLWNIQTDT 224 +RI + T + G+ I F ++ + + + + W++ + Sbjct: 271 TLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLSLEN 330 Query: 225 L-------VAIFGGVEGHRD--------EVLSADYDLLGE---KIMSCGMDHSLKLWRIN 266 L + F + GH +V ++ G + + + Sbjct: 331 LTHSQTAKIEKFSRLYGHESTQRSFENFKVAHLQNSQTNSVHGIVLLQGNNGWINILHST 390 Query: 267 SKR-MMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCE 325 S +M E + +P K + + + G Sbjct: 391 SGLWLMGCKIEGVITDFCIDYQPISRGKFRTILIAVNAYGEVWEFDLNKNG--------- 441 Query: 326 NAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGK 385 + I WK +T + + ++ S + LA+G++ G Sbjct: 442 HVIRRWKDQGGVG-----------ITKIQVGGGTTTTCPALQISKIKQNRWLAVGSESGF 490 Query: 386 LYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVC 429 + ++D + I FS D IL Sbjct: 491 VNLYDRNNAMTSSTPTPVAALDQLTTTISNLQFSPDGQILCMAS 534 Score = 40.3 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 25/149 (16%), Positives = 52/149 (34%), Gaps = 11/149 (7%) Query: 127 HSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIIN------PITM 180 QG + + + V + + LAV G + + + T Sbjct: 448 KDQGGVGITKIQVGGGTTTTCPALQISK--IKQNRWLAVGSESGFVNLYDRNNAMTSSTP 505 Query: 181 QCIKHYVGHGNAINELKFHPRDPNLLLSVSK--DHALRLWNIQTDTLVAIFGGVEGHRDE 238 + I+ L+F P D +L S+ ALRL ++ + ++ + + + Sbjct: 506 TPVAALDQLTTTISNLQFSP-DGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGK 564 Query: 239 VLSADYDLLGEKIMSCGMDHSLKLWRINS 267 V S + G + ++LW++N Sbjct: 565 VTSVAFSPSGGLLAVGNEQGKVRLWKLNH 593 >5WLC-LH nrPDB Length = 896 Score = 43.0 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 18/67 (26%), Positives = 34/67 (50%), Gaps = 2/67 (2%) Query: 157 NTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALR 216 + LAV + G+I I++ +Q I+ H +++ L F D + LLS + + Sbjct: 265 DNMGQQLAVGFASGVISIVSLADLQ-IRLLKWHIDSVLSLSFS-HDGSYLLSGGWEKVMS 322 Query: 217 LWNIQTD 223 LW ++T+ Sbjct: 323 LWQLETN 329 Score = 42.2 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 10/34 (29%), Positives = 18/34 (52%) Query: 235 HRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSK 268 H D VLS + G ++S G + + LW++ + Sbjct: 296 HIDSVLSLSFSHDGSYLLSGGWEKVMSLWQLETN 329 Score = 33.0 bits (73), Expect = 0.27, Method: Composition-based stats. Identities = 12/68 (17%), Positives = 27/68 (39%), Gaps = 5/68 (7%) Query: 305 HRNYVDCVRWL--GDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCD 362 H + V + + G +LS E + W+ +E + + P + + I + Q + Sbjct: 296 HIDSVLSLSFSHDGSYLLSGGWEKVMSLWQ---LETNSQQFLPRLNGIIIDCQVLGPQGN 352 Query: 363 IWYMRFSM 370 + + M Sbjct: 353 YYSLILQM 360 >3DWL-C nrPDB Length = 377 Score = 42.2 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 29/287 (10%), Positives = 78/287 (27%), Gaps = 32/287 (11%) Query: 147 FYTCAWTYDSNTSHPLLAVAGSRGIIRII--NPITMQCIKHYVGHGNAINELKFHPRDPN 204 ++ + N+ + + + + + + + H + + + P+ Sbjct: 10 LPKPSYEHAFNSQRTEFVTTTATNQVELYEQDGNGWKHARTFSDHDKIVTCVDWAPKSNR 69 Query: 205 LLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 +++ S+D ++ + D + + +K + + Sbjct: 70 -IVTCSQDRNAYVYEKRPDGTWKQTLVLLRLNRAATFVRWSPNEDKFAVGSGARVISV-- 126 Query: 265 INSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSC 324 +E+ + RP S + + D H N V L+ + Sbjct: 127 ------CYFEQENDWWVSKHLKRPLRSTIL------SLDWHPNNV--------LLAAGCA 166 Query: 325 ENAIVCWKPGKMEDDIDKIK---PSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGN 381 + + D S + S + + FS LA Sbjct: 167 DRKAYVLSAYVRDVDAKPEASVWGSRLPFNTVCAEYPSGGWVHAVGFSPS--GNALAYAG 224 Query: 382 QVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAV 428 + + P + +T +R ++ +S+I+ A Sbjct: 225 HDSSVTI--AYPSAPEQPPRALITVKLSQLPLRSLLWANESAIVAAG 269 >3DW8-B nrPDB Length = 447 Score = 42.2 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 54/385 (14%), Positives = 107/385 (27%), Gaps = 94/385 (24%) Query: 127 HSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCI--- 183 Q ++ VD D E + N S LLA G + I I Sbjct: 9 DIQWCFSQVKGAVDDDVAEADIISTVEF--NHSGELLATGDKGGRVVIFQQEQENKIQSH 66 Query: 184 --------KHYVGHG------------NAINELKFHPRDP--NLLLSVSKDHALRLWNIQ 221 + H IN++++ P+ LLS + D ++LW I Sbjct: 67 SRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLS-TNDKTIKLWKIS 125 Query: 222 TD-------------------TLVAIFGGVEG------------------HRDEVLSADY 244 T V H + S Sbjct: 126 ERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISI 185 Query: 245 DLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDI 304 + E +S D + LW + E D + N + + + + + Sbjct: 186 NSDYETYLSA-DDLRINLWHL----------EITDRSFNIVDIKPANMEELTEVITAAEF 234 Query: 305 HRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIW 364 H N + + + C+ + + + SN + S D+ Sbjct: 235 HPNSCNTFVYSSSKGTIRLCD--MRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVK 292 Query: 365 YMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPH----------KAKCTTLTHHKCGAAIR 414 + + + + + + VWDL +E+ ++K +L + C Sbjct: 293 F-----SHSGRYMMTRDYLS-VKVWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKF 346 Query: 415 QTSFSRDSSILIAVCDDASIWRWDR 439 + ++ S+++ + +DR Sbjct: 347 ECCWNGSDSVVMTGSYNNFFRMFDR 371 >5WLC-LL nrPDB Length = 643 Score = 41.1 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 16/126 (12%), Positives = 44/126 (34%), Gaps = 10/126 (7%) Query: 138 YVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELK 197 + + ++ LL + S I +I+ + + + GH + ++ L+ Sbjct: 139 HFRINNCVQLNKLTIVPAGDSVAQLLVASHS---ISLIDIEEKKVVMTFPGHVSPVSTLQ 195 Query: 198 FHPRDPNLLLSVSK-DHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGM 256 +S ++ D L +++I + + ++ + + I Sbjct: 196 V--ITNEFFISGAEGDRFLNVYDIHSGMTKCVLVA----ESDIKELSHSGQADSIAVTTE 249 Query: 257 DHSLKL 262 D SL++ Sbjct: 250 DGSLEI 255 >2I3T-A nrPDB Length = 341 Score = 41.1 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 15/78 (19%), Positives = 28/78 (35%), Gaps = 9/78 (11%) Query: 192 AINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGV-------EGHRDEVLSADY 244 +N ++F PR L + D + WN+QT + F D +L Sbjct: 253 PVNSIEFSPRH-KFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACSDNILCLAT 311 Query: 245 DLLGEKIMSCGMDHSLKL 262 + +D +++L Sbjct: 312 S-DDTFKTNAAIDQTIEL 328 Score = 39.9 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 24/135 (17%), Positives = 47/135 (34%), Gaps = 13/135 (9%) Query: 89 KEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQG------EIRLLQSYVDAD 142 + + V +EG + RV + QG + + + Sbjct: 189 ESGLKYQIRDVALLPKEQEG---YACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNL 245 Query: 143 ADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHY-VGHGNAINELKFHPR 201 D N + + + H L AGS GII N T + IK++ + +++ ++ Sbjct: 246 KDTNLAYPVNSIEFSPRHKFLYTAGSDGIISCWNLQTRKKIKNFAKFNEDSVVKIACS-- 303 Query: 202 DPNLLLSVSKDHALR 216 N+L + D + Sbjct: 304 -DNILCLATSDDTFK 317 Score = 29.9 bits (65), Expect = 2.3, Method: Composition-based stats. Identities = 12/92 (13%), Positives = 31/92 (33%), Gaps = 12/92 (13%) Query: 193 INELKFHPRDPNLLLSVSKDHALRLW---NIQTDTLVAIFGGVEGHR---------DEVL 240 I ++ P++ S D + + + D + HR V Sbjct: 196 IRDVALLPKEQEGYACSSIDGRVAVEFFDDQGDDYNSSKRFAFRCHRLNLKDTNLAYPVN 255 Query: 241 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMN 272 S ++ + + + G D + W + +++ + Sbjct: 256 SIEFSPRHKFLYTAGSDGIISCWNLQTRKKIK 287 >4AV8-A nrPDB Length = 339 Score = 37.6 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 24/167 (14%), Positives = 54/167 (32%), Gaps = 19/167 (11%) Query: 187 VGHGNAINELKFHPRDPNLLLSVSKDHA-LRLWNIQTDTLVAIFGGVEGHRDEVLSADYD 245 H N + ++ + R +++ + S+D +R++ LV F ++ + Sbjct: 176 KAHANPVKMVRLN-RKGDMVATCSQDGTLIRVFQTDNGVLVREFRRGLDRTS-IIDMRWS 233 Query: 246 LLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIH 305 G K+ D W + +N + R + I+ F + Sbjct: 234 PDGSKLAVVS-DK----W---------TLHVFEVFNDAENKRHVLKDWINIKYFQSEWSI 279 Query: 306 RNYVDCVRWLGD--LILSKSCENAIVCWKPGKMEDDIDKIKPSESNV 350 N+ V + I S ++ W ++ D + +V Sbjct: 280 CNFKLKVSKGSNDCKIAWISDTGLVIVWPNRRLADTFKLNYNDDEHV 326 >4YHC-A nrPDB Length = 468 Score = 36.4 bits (82), Expect = 0.026, Method: Composition-based stats. Identities = 21/110 (19%), Positives = 39/110 (35%), Gaps = 5/110 (4%) Query: 189 HGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLG 248 H I ++ + SV D +L +W+++ + E + + D G Sbjct: 29 HQLDILKIAVS-ENYKTFASVGLDRSLVVWDLRQ-WCTKLVLSKEQMPRTLKAIALDPQG 86 Query: 249 EKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPD 298 + D +L + + S +M ++ SY PN F H D Sbjct: 87 NYVSLFSKD-TLFILNVESPSLM--LQHSYHSKPNSKLNVFWMPGTHKDD 133 Score = 35.3 bits (79), Expect = 0.054, Method: Composition-based stats. Identities = 25/132 (18%), Positives = 42/132 (31%), Gaps = 10/132 (7%) Query: 210 SKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKR 269 S D L + I H+ ++L + S G+D SL +W + Sbjct: 10 STDTTL------HEEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRSLVVWDLRQWC 63 Query: 270 MMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRD--IHRNYVDCVRWLGDLILSKSCENA 327 + S + P + + ++ ++D N L SK Sbjct: 64 TKLVL--SKEQMPRTLKAIALDPQGNYVSLFSKDTLFILNVESPSLMLQHSYHSKPNSKL 121 Query: 328 IVCWKPGKMEDD 339 V W PG +DD Sbjct: 122 NVFWMPGTHKDD 133 >5GRS-A nrPDB Length = 396 Score = 33.0 bits (73), Expect = 0.30, Method: Composition-based stats. Identities = 24/135 (17%), Positives = 44/135 (32%), Gaps = 16/135 (11%) Query: 210 SKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKR 269 S D L + I H+ ++L + S G+D L +W + Sbjct: 10 STDTTL------HEEKFRIEPVPVHHQLDILKIAVSENYKTFASVGLDRCLVVWDLRQWC 63 Query: 270 MMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSC----- 324 + S + P + + ++ ++D ++ V L+L S Sbjct: 64 TKLVL--SKEQMPRTLKAIALDPQGNYVSLFSKD--TLFILNVE-SPSLMLQHSYHCKPN 118 Query: 325 ENAIVCWKPGKMEDD 339 V W PG +DD Sbjct: 119 SKLNVFWMPGTHKDD 133 >3WJ9-A nrPDB Length = 412 Score = 32.2 bits (71), Expect = 0.48, Method: Composition-based stats. Identities = 27/200 (13%), Positives = 54/200 (27%), Gaps = 22/200 (11%) Query: 99 VQFNWHSKEGDPLVFATV-----GSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWT 153 VQF W++ LV N + G VD D + + W Sbjct: 218 VQFKWNALGTSLLVLTQTEVDKSNKNYYGETNLYLLGITGQFDCRVDLDREGPIHDVCWN 277 Query: 154 YDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSV--SK 211 DS + I + + N L F P +LL+ + Sbjct: 278 ADSKEFG--IVYGYMPAKTAIFDNRA-NVVSIIP--PAPRNTLIFSPNSRYILLAGFGNL 332 Query: 212 DHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGM------DHSLKLWRI 265 ++ +++ + ++ + +++ D+S+K+W I Sbjct: 333 QGSIDIFDAANNMKKITTVEAANCTY----CEFSPDSQFLLTAVTSPRLRVDNSIKIWHI 388 Query: 266 NSKRMMNAIKESYDYNPNKT 285 M + Sbjct: 389 TGAPMFYEEFNELYQAFWRP 408 >5AMS-A nrPDB Length = 431 Score = 31.4 bits (69), Expect = 0.77, Method: Composition-based stats. Identities = 7/29 (24%), Positives = 12/29 (41%) Query: 235 HRDEVLSADYDLLGEKIMSCGMDHSLKLW 263 H D V + + + + G D+ LW Sbjct: 64 HTDSVFAIGHHPNLPLVCTGGGDNLAHLW 92 Score = 31.4 bits (69), Expect = 0.81, Method: Composition-based stats. Identities = 20/150 (13%), Positives = 40/150 (26%), Gaps = 16/150 (10%) Query: 152 WTYDSNTSHPLLAVAGSRGIIRII--NPITMQCIKHYVG--HGNAINELKFHPRDPNL-- 205 W T A + G + N + G H + +F D Sbjct: 159 WLKTHPTIARTFAFGATDGSVWCYQINEQDGSLEQLMSGFVHQQDCSMGEFINTDKGENT 218 Query: 206 --LLSVSKDHALRLWNIQTDTLV--AIFGGVEGHRDEVLSADYDL------LGEKIMSCG 255 L++ S D + WN T + ++G +S + Sbjct: 219 LELVTCSLDSTIVAWNCFTGQQLFKITQAEIKGLEAPWISLSLAPETLTKGNSGVVACGS 278 Query: 256 MDHSLKLWRINSKRMMNAIKESYDYNPNKT 285 + L + N+ + + + P + Sbjct: 279 NNGLLAVINCNNGGAILHLSTVIELKPEQD 308 >4W84-A nrPDB Length = 340 Score = 31.1 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 18/122 (14%), Positives = 36/122 (29%), Gaps = 10/122 (8%) Query: 207 LSVSK--DHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWR 264 + D L + ++ +E D ++ + D S +W Sbjct: 183 ATGGNNADRVLIICTYGHNSDEPTLKDLEIPSDPNIAVALHTYTPYFFTYVADGSYSVWN 242 Query: 265 INSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDF-STRDIHRNYVDCVRWLGDLILSKS 323 + K + N + I + I + N D VRW+GD + + Sbjct: 243 -------GSKKNDITWQYNNIKKYLIDKGIPVVITETGAQFKENTEDIVRWIGDYVGTLD 295 Query: 324 CE 325 + Sbjct: 296 QD 297 >6BN7-A nrPDB Length = 864 Score = 30.3 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 23/148 (15%), Positives = 45/148 (30%), Gaps = 31/148 (20%) Query: 170 GIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIF 229 G I + + + + + N L S + +RL+ T+ + Sbjct: 570 GRIVVFQYSDGKLQTVA---EKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKELRTE 626 Query: 230 GGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPF 289 H + +++ G+ I+ + S+ L Y P + N Sbjct: 627 CN---HYNNIMALYLKTKGDFILVGDLMRSVLL---------------LAYKPMEGNFEE 668 Query: 290 ISQKIHFPDFSTRDIHRNYVDCVRWLGD 317 I RD + N++ V L D Sbjct: 669 I----------ARDFNPNWMSAVEILDD 686 >5SUM-A nrPDB Length = 468 Score = 29.5 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 5/25 (20%), Positives = 16/25 (64%) Query: 247 LGEKIMSCGMDHSLKLWRINSKRMM 271 G+ ++ G+D ++++ I + +M+ Sbjct: 376 DGKYLLQGGLDRYVRIFDIKTNKML 400 >3MWP-A nrPDB Length = 577 Score = 29.1 bits (63), Expect = 3.9, Method: Composition-based stats. Identities = 5/25 (20%), Positives = 13/25 (52%) Query: 248 GEKIMSCGMDHSLKLWRINSKRMMN 272 G + G D +++W + + ++N Sbjct: 157 GNQGARAGRDGVVRVWDVKNAELLN 181 >5CWW-B nrPDB Length = 595 Score = 28.7 bits (62), Expect = 5.1, Method: Composition-based stats. Identities = 9/40 (22%), Positives = 21/40 (52%), Gaps = 2/40 (5%) Query: 190 GNAINELKFHPR--DPNLLLSVSKDHALRLWNIQTDTLVA 227 +A+ +HP + + L++V++D +R+W + T Sbjct: 172 RSAVVSAVWHPLGVNGHALVTVTEDAIVRVWELSTADRWT 211 >1BXK-A nrPDB Length = 355 Score = 28.4 bits (61), Expect = 7.4, Method: Composition-based stats. Identities = 17/90 (18%), Positives = 23/90 (25%), Gaps = 13/90 (14%) Query: 218 WNIQTDTLVAIFGGVEGHRDEVL------------SADYDLLGEKIMS-CGMDHSLKLWR 264 WN T+ + F DEV + Y S DH ++ W Sbjct: 116 WNALTEDKKSAFRFHHISTDEVYGDLHSTDDFFTETTPYAPSSPYSASKASSDHLVRAWL 175 Query: 265 INSKRMMNAIKESYDYNPNKTNRPFISQKI 294 S +Y P I I Sbjct: 176 RTYGLPTLITNCSNNYGPYHFPEKLIPLMI 205 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.306 0.112 0.299 Lambda K H 0.267 0.0351 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,672,955 Number of Sequences: 36641 Number of extensions: 582711 Number of successful extensions: 4194 Number of sequences better than 10.0: 150 Number of HSP's better than 10.0 without gapping: 204 Number of HSP's successfully gapped in prelim test: 52 Number of HSP's that attempted gapping in prelim test: 1492 Number of HSP's gapped (non-prelim): 899 length of query: 441 length of database: 10,336,785 effective HSP length: 100 effective length of query: 341 effective length of database: 6,672,685 effective search space: 2275385585 effective search space used: 2275385585 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 60 (27.9 bits)