BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= O75317 (370 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5L8W-A nrPDB 776 0.0 5K1A-A nrPDB 694 0.0 5L8H-A nrPDB 670 0.0 4FIP-A nrPDB 140 8e-34 2GFO-A nrPDB 125 2e-29 3MTN-A nrPDB 118 4e-27 2Y6E-A nrPDB 113 1e-25 6CPM-C nrPDB 110 1e-24 5J7T-A nrPDB 108 3e-24 2F1Z-A nrPDB 108 3e-24 5JTV-A nrPDB 108 5e-24 5JTJ-A nrPDB 108 6e-24 5TXK-A nrPDB 107 7e-24 6DGF-A nrPDB 107 7e-24 5WCH-A nrPDB 91 9e-19 5OHN-A nrPDB 77 1e-14 5OHK-A nrPDB 73 2e-13 5CHV-A nrPDB 72 4e-13 2AYN-A nrPDB 65 4e-11 5GJQ-x nrPDB 65 4e-11 6HEH-A nrPDB 62 5e-10 5GVI-A nrPDB 61 7e-10 3IHP-A nrPDB 51 6e-07 6H4J-A nrPDB 51 9e-07 5O71-A nrPDB 50 2e-06 5MPC-8 nrPDB 47 1e-05 1VJV-A nrPDB 47 1e-05 6H4H-A nrPDB 43 2e-04 3JCR-V nrPDB 35 0.059 3TF5-A nrPDB 33 0.27 1BGX-T nrPDB 31 0.92 4N56-A nrPDB 31 0.97 3W7W-A nrPDB 31 0.98 4NQW-A nrPDB 29 2.8 2EX5-A nrPDB 28 4.3 2O3J-A nrPDB 28 8.1 2ESB-A nrPDB 27 9.6 >5L8W-A nrPDB Length = 376 Score = 776 bits (2004), Expect = 0.0, Method: Compositional matrix adjust. Identities = 370/370 (100%), Positives = 370/370 (100%) Query: 1 MEILMTVSKFASICTMGANASALEKEIGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFC 60 MEILMTVSKFASICTMGANASALEKEIGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFC Sbjct: 7 MEILMTVSKFASICTMGANASALEKEIGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFC 66 Query: 61 RPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDNY 120 RPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDNY Sbjct: 67 RPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDNY 126 Query: 121 MQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTL 180 MQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTL Sbjct: 127 MQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTL 186 Query: 181 TNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQ 240 TNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQ Sbjct: 187 TNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQ 246 Query: 241 EAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDRMY 300 EAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDRMY Sbjct: 247 EAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDRMY 306 Query: 301 DLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSES 360 DLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSES Sbjct: 307 DLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSES 366 Query: 361 GYILFYQSRD 370 GYILFYQSRD Sbjct: 367 GYILFYQSRD 376 >5K1A-A nrPDB Length = 331 Score = 694 bits (1792), Expect = 0.0, Method: Compositional matrix adjust. Identities = 331/331 (100%), Positives = 331/331 (100%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVG 99 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVG Sbjct: 1 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVG 60 Query: 100 VIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNID 159 VIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNID Sbjct: 61 VIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNID 120 Query: 160 NENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRGF 219 NENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRGF Sbjct: 121 NENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRGF 180 Query: 220 SNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVV 279 SNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVV Sbjct: 181 SNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVV 240 Query: 280 FPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVEKI 339 FPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVEKI Sbjct: 241 FPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVEKI 300 Query: 340 DAQAIEEFYGLTSDISKNSESGYILFYQSRD 370 DAQAIEEFYGLTSDISKNSESGYILFYQSRD Sbjct: 301 DAQAIEEFYGLTSDISKNSESGYILFYQSRD 331 >5L8H-A nrPDB Length = 359 Score = 670 bits (1729), Expect = 0.0, Method: Compositional matrix adjust. Identities = 318/359 (88%), Positives = 335/359 (93%) Query: 12 SICTMGANASALEKEIGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYK 71 SIC MG NASALEK+IGPEQFP+NEHYFGLVNFGNTCY NSVLQALYFCRPFRE VLAYK Sbjct: 1 SICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYVNSVLQALYFCRPFRENVLAYK 60 Query: 72 SQPRKKESLLTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNY 131 +Q +KKE+LLTCLADLFHSIATQKKKVGVIPPKKFI+RLRKEN+LFDNYMQQDAHEFLNY Sbjct: 61 AQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNY 120 Query: 132 LLNTIADILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCET 191 LLNTIADILQEE+KQEKQNG+L NGN++ N+ P+ TWVHEIFQGTLTNETRCL CET Sbjct: 121 LLNTIADILQEEKKQEKQNGKLKNGNMNEPAENNKPELTWVHEIFQGTLTNETRCLNCET 180 Query: 192 ISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKL 251 +SSKDEDFLDLSVDVEQNTSITHCLR FSNTETLCSE KYYCE C SKQEA KRM+VKKL Sbjct: 181 VSSKDEDFLDLSVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKL 240 Query: 252 PMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGS 311 PMILALHLKRFKYM+QL RYTKLSYRVVFPLELRLFNTS DA N DRMYDLVAVVVHCGS Sbjct: 241 PMILALHLKRFKYMEQLRRYTKLSYRVVFPLELRLFNTSSDAVNLDRMYDLVAVVVHCGS 300 Query: 312 GPNRGHYIAIVKSHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRD 370 GPNRGHYI IVKSH FWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSR+ Sbjct: 301 GPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRE 359 >4FIP-A nrPDB Length = 476 Score = 140 bits (353), Expect = 8e-34, Method: Compositional matrix adjust. Identities = 108/357 (30%), Positives = 168/357 (47%), Gaps = 53/357 (14%) Query: 40 GLVNFGNTCYCNSVLQAL----YFCRPFREKVLAYKSQPRKKESLLTCLAD-----LFHS 90 GL+N GNTC+ +S+LQ L YF R ++ + + R + +C D L+ + Sbjct: 143 GLINMGNTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELYGA 202 Query: 91 IATQKKKVGVIPPKK------FITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEER 144 + T++ + +T K N+ Y QQDAHEF +++N I Sbjct: 203 LNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQI-------- 254 Query: 145 KQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDED-FLDLS 203 + LPN + NN + VH +F+G+L + C C+ S D FLDLS Sbjct: 255 -HQSYVLDLPNAKEVSRANNKQCECI-VHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLS 312 Query: 204 VDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFK 263 +D++ + CL F E L ++ Y+C EC S Q+A K++ + KLP +L L LKRF+ Sbjct: 313 LDIKDKKKLYECLDSFHKKEQL-KDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFE 371 Query: 264 Y-MDQLHRYTKLSYRVVFPLELRLFN---------TSGDATNPDRMYDLVAVVVHCGSGP 313 + ++ +R KL + FP L + N S + PD +Y+L+ +V H G+ Sbjct: 372 HLLNGSNR--KLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGT-V 428 Query: 314 NRGHYIAIVK-SHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSR 369 N GHYIA K S W F+D +V I + + + E Y+LFY R Sbjct: 429 NEGHYIAFCKISGGQWFKFNDSMVSSISQEEVLK------------EQAYLLFYTIR 473 >2GFO-A nrPDB Length = 396 Score = 125 bits (315), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 104/325 (32%), Positives = 150/325 (46%), Gaps = 48/325 (14%) Query: 40 GLVNFGNTCYCNSVLQAL--------YFCRPF------REKVLAYKSQPRKKESLLTCLA 85 GL N GNTCY NS+LQ L YF R R +L +K + +A Sbjct: 64 GLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGE----------VA 113 Query: 86 DLFHSI--ATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEE 143 + F I A + I PK F + K N+ F Y QQD+ E L +L+ D L E+ Sbjct: 114 EEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLM----DGLHED 169 Query: 144 RKQEKQNGRLPNGNIDNENNNSTPDPTW----------VHEIFQGTLTNETRCLTCETIS 193 + R N D+ ++ + W + +FQG + +CLTC S Sbjct: 170 LNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKS 229 Query: 194 SKDEDFLDLSVDVEQNTSIT--HCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKL 251 E F+ LS+ + + T CLR FS E L ++YC CR+++++ K++++ KL Sbjct: 230 RTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKL 289 Query: 252 PMILALHLKRFKYMDQLHRYTKLSYRVVFPLE-LRLFNTSGDATNPDRMYDLVAVVVHCG 310 P +L +HLKRF Y + + KL V FPLE L L N + Y+L +V H G Sbjct: 290 PPVLLVHLKRFSYDGRWKQ--KLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYG 347 Query: 311 SGPNRGHYIAIVK--SHDFWLLFDD 333 G + GHY A K + W FDD Sbjct: 348 -GLDGGHYTAYCKNAARQRWFKFDD 371 >3MTN-A nrPDB Length = 373 Score = 118 bits (296), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 102/370 (27%), Positives = 158/370 (42%), Gaps = 64/370 (17%) Query: 38 YFGLVNFGNTCYCNSVLQALYFCRP---------FREKVLAYKSQPRKKESLLTCLADLF 88 + GL N GNTC+ N+VLQ L RP FR++V E+ + L+ Sbjct: 22 HVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALW 81 Query: 89 HSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEK 148 H + + + P +F +K F Y QQDA EFL L+ + L+ R+ + Sbjct: 82 HPDSCE-----AVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLH--LEINRRGRR 134 Query: 149 QNGRLPNGNIDNE-------------NNNSTPDPTW----------VHEIFQGTLTNETR 185 L NG + + +++ + W + ++F G L + + Sbjct: 135 APPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLK 194 Query: 186 CLTCETISSKDEDFLDLSVDVEQN------TSITHCLRGFSNTETLCSEYKYYCEECRSK 239 C C S+ E F DLS+ + + S+ C F+ E L SE C+ CR K Sbjct: 195 CQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQK 254 Query: 240 QEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLE-LRLFNTSGD-ATNPD 297 + K++ V++ P IL LHL RF K S V FPL+ L L + + D A +P Sbjct: 255 TRSTKKLTVQRFPRILVLHLNRFSA--SRGSIKKSSVGVDFPLQRLSLGDFASDKAGSP- 311 Query: 298 RMYDLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKN 357 +Y L A+ H GS + GHY A+ + W +++D V + + Sbjct: 312 -VYQLYALCNHSGS-VHYGHYTALCRCQTGWHVYNDSRVSPVSENQVA------------ 357 Query: 358 SESGYILFYQ 367 S GY+LFYQ Sbjct: 358 SSEGYVLFYQ 367 >2Y6E-A nrPDB Length = 367 Score = 113 bits (283), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 99/370 (26%), Positives = 160/370 (43%), Gaps = 59/370 (15%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLA--YKSQPRK------KESLLTCLADLFHSI 91 GL N GNTC+ NS LQ L P + L Y+++ + K + A+L + Sbjct: 10 GLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQM 69 Query: 92 ATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQ----- 146 + + + P+ F T++ + F Y QQD+ E L +LL+ + + L +K+ Sbjct: 70 WSGRD--AHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLEL 127 Query: 147 EKQNGRLPNGNIDNE--NNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSV 204 + NGR P+ + E N+ + + + + F G + C C +S + F L++ Sbjct: 128 KDANGR-PDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTL 186 Query: 205 DV-------------------EQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKR 245 + + ++ C+ F+ ETL +YC C+ Q+A K+ Sbjct: 187 PLPLKKDRVMEGPMLQPQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKK 246 Query: 246 MKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDR---MYDL 302 + LP IL +HLKRF Y +RY + V +R N S N +YDL Sbjct: 247 FDLWSLPKILVVHLKRFSY----NRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDL 302 Query: 303 VAVVVHCGSGPNRGHYIAIVKS--HDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSES 360 +AV H G+ GHY A K+ + W FDD V L S+ +++ Sbjct: 303 IAVSNHYGAM-GVGHYTAYAKNKLNGKWYYFDDSNVS------------LASEDQIVTKA 349 Query: 361 GYILFYQSRD 370 Y+LFYQ RD Sbjct: 350 AYVLFYQRRD 359 >6CPM-C nrPDB Length = 349 Score = 110 bits (274), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 104/352 (29%), Positives = 153/352 (43%), Gaps = 47/352 (13%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKK-ESLLTCLADLFHSIATQKK-- 96 GL N GNTC+ NS +Q L P E L K Q ++ L ++ S A K Sbjct: 21 GLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQM 80 Query: 97 ---KVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQ-----EK 148 K + P+ F T++ + F Y QQD E L +LL+ + + L RK+ + Sbjct: 81 WSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKD 140 Query: 149 QNGRLPNGNIDNE--NNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDF----LDL 202 +GR P+ + E N+ + + + +IF G + C C IS + F L L Sbjct: 141 ADGR-PDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPL 199 Query: 203 SVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRF 262 + + + C+ F+ E L +E +YC C+ Q+A K++ + LP +L +HLKRF Sbjct: 200 PMPKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRF 259 Query: 263 KYMDQLHRYT--KLSYRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIA 320 Y RY KL V FP+ D Y+L+AV H G GHY A Sbjct: 260 SY----SRYMRDKLDTLVDFPI--------NDLDMSGCRYNLIAVSNHYGGM-GGGHYTA 306 Query: 321 IVKSHD--FWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRD 370 K+ D W FDD V I S++ Y+LFYQ +D Sbjct: 307 FAKNKDDGKWYYFDDSSVSTASEDQIV------------SKAAYVLFYQRQD 346 >5J7T-A nrPDB Length = 671 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 98/337 (29%), Positives = 147/337 (43%), Gaps = 39/337 (11%) Query: 38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ-PRKKESLLTCLADLFHSIATQKK 96 Y GL N G TCY NS+LQ L+F R+ V ++ +S+ L +F+ + K Sbjct: 3 YVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDK 62 Query: 97 KVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNG 156 VG KK E D++MQ D E LL+ + + K G G Sbjct: 63 PVGT---KKLTKSFGWET--LDSFMQHDVQELCRVLLDNV---------ENKMKGTCVEG 108 Query: 157 NIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCL 216 I ++F+G + + +C + S + ED+ D+ + ++ +I Sbjct: 109 TIP--------------KLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESF 154 Query: 217 RGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSY 276 + E L + KY E QEA K +K LP +L L L RF Y Q + K++ Sbjct: 155 VDYVAVEQLDGDNKYDAGE-HGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKIND 213 Query: 277 RVVFPLELRL--FNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIV--KSHDFWLLFD 332 R FP +L L F D +P Y L AV+VH G + GHY+ + K W FD Sbjct: 214 RFEFPEQLPLDEFLQKTDPKDPAN-YILHAVLVHSGDN-HGGHYVVYLNPKGDGKWCKFD 271 Query: 333 DDIVEK-IDAQAIEEFYGLTSD--ISKNSESGYILFY 366 DD+V + +AIE YG D ++ + Y+L Y Sbjct: 272 DDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVY 308 >2F1Z-A nrPDB Length = 522 Score = 108 bits (271), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 98/337 (29%), Positives = 147/337 (43%), Gaps = 39/337 (11%) Query: 38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ-PRKKESLLTCLADLFHSIATQKK 96 Y GL N G TCY NS+LQ L+F R+ V ++ +S+ L +F+ + K Sbjct: 175 YVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDK 234 Query: 97 KVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNG 156 VG KK E D++MQ D E LL+ + + K G G Sbjct: 235 PVGT---KKLTKSFGWET--LDSFMQHDVQELCRVLLDNV---------ENKMKGTCVEG 280 Query: 157 NIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCL 216 I ++F+G + + +C + S + ED+ D+ + ++ +I Sbjct: 281 TIP--------------KLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESF 326 Query: 217 RGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSY 276 + E L + KY E QEA K +K LP +L L L RF Y Q + K++ Sbjct: 327 VDYVAVEQLDGDNKYDAGE-HGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKIND 385 Query: 277 RVVFPLELRL--FNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIV--KSHDFWLLFD 332 R FP +L L F D +P Y L AV+VH G + GHY+ + K W FD Sbjct: 386 RFEFPEQLPLDEFLQKTDPKDPAN-YILHAVLVHSGDN-HGGHYVVYLNPKGDGKWCKFD 443 Query: 333 DDIVEK-IDAQAIEEFYGLTSD--ISKNSESGYILFY 366 DD+V + +AIE YG D ++ + Y+L Y Sbjct: 444 DDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVY 480 >5JTV-A nrPDB Length = 594 Score = 108 bits (269), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 98/337 (29%), Positives = 147/337 (43%), Gaps = 39/337 (11%) Query: 38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ-PRKKESLLTCLADLFHSIATQKK 96 Y GL N G TCY NS+LQ L+F R+ V ++ +S+ L +F+ + K Sbjct: 22 YVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDK 81 Query: 97 KVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNG 156 VG KK E D++MQ D E LL+ + + K G G Sbjct: 82 PVGT---KKLTKSFGWET--LDSFMQHDVQELCRVLLDNV---------ENKMKGTCVEG 127 Query: 157 NIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCL 216 I ++F+G + + +C + S + ED+ D+ + ++ +I Sbjct: 128 TIP--------------KLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESF 173 Query: 217 RGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSY 276 + E L + KY E QEA K +K LP +L L L RF Y Q + K++ Sbjct: 174 VDYVAVEQLDGDNKYDAGE-HGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKIND 232 Query: 277 RVVFPLELRL--FNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIV--KSHDFWLLFD 332 R FP +L L F D +P Y L AV+VH G + GHY+ + K W FD Sbjct: 233 RFEFPEQLPLDEFLQKTDPKDPAN-YILHAVLVHSGDN-HGGHYVVYLNPKGDGKWCKFD 290 Query: 333 DDIVEK-IDAQAIEEFYGLTSD--ISKNSESGYILFY 366 DD+V + +AIE YG D ++ + Y+L Y Sbjct: 291 DDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVY 327 >5JTJ-A nrPDB Length = 387 Score = 108 bits (269), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 98/337 (29%), Positives = 147/337 (43%), Gaps = 39/337 (11%) Query: 38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQP-RKKESLLTCLADLFHSIATQKK 96 Y GL N G TCY NS+LQ L+F R+ V ++ +S+ L +F+ + K Sbjct: 22 YVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDK 81 Query: 97 KVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNG 156 VG KK E D++MQ D E LL+ + + K G G Sbjct: 82 PVGT---KKLTKSFGWET--LDSFMQHDVQELCRVLLDNV---------ENKMKGTCVEG 127 Query: 157 NIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCL 216 I ++F+G + + +C + S + ED+ D+ + ++ +I Sbjct: 128 TIP--------------KLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESF 173 Query: 217 RGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSY 276 + E L + KY E QEA K +K LP +L L L RF Y Q + K++ Sbjct: 174 VDYVAVEQLDGDNKYDAGE-HGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKIND 232 Query: 277 RVVFPLELRL--FNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIV--KSHDFWLLFD 332 R FP +L L F D +P Y L AV+VH G + GHY+ + K W FD Sbjct: 233 RFEFPEQLPLDEFLQKTDPKDPAN-YILHAVLVHSGDN-HGGHYVVYLNPKGDGKWCKFD 290 Query: 333 DDIVEK-IDAQAIEEFYGLTSD--ISKNSESGYILFY 366 DD+V + +AIE YG D ++ + Y+L Y Sbjct: 291 DDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVY 327 >5TXK-A nrPDB Length = 372 Score = 107 bits (268), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 113/360 (31%), Positives = 161/360 (44%), Gaps = 55/360 (15%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAY---KSQPRKKESLLTCLADLFHSIATQKK 96 GL+N GNT Y NS+LQAL+ FR VL SQP L+T L LF + ++ Sbjct: 20 GLINLGNTSYVNSILQALFMASDFRHCVLRLTENNSQP-----LMTKLQWLFGFLEHSQR 74 Query: 97 KVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRL--- 153 I P+ F++ F QQD E+L YLL D L EE EK R+ Sbjct: 75 PA--ISPENFLSA--SWTPWFSPGTQQDCSEYLKYLL----DRLHEE---EKTGTRICQK 123 Query: 154 --PNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSV-----DV 206 + + P T V ++F G + CL C +SS++E F DLS+ Sbjct: 124 LKQSSSPSPPEEPPAPSSTSVEKMFGGKIVTRICCLCCLNVSSREEAFTDLSLAFPPPGS 183 Query: 207 EQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMD 266 E + S+ + F + E L +E +YYCE C S Q+A K +++ + P L L L RF + Sbjct: 184 EGSRSVLDLVNYFLSPEKLTAENRYYCESCASLQDAEKVVELSQGPCYLILTLLRFSFDL 243 Query: 267 QLHRYTKLSYRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVK--- 323 + R K+ V PL LRL G + YDL +VVVH G GHY + Sbjct: 244 RTMRRRKILDDVSIPLLLRLPLAGGRG----QAYDLCSVVVHSGVSSESGHYYCYAREGA 299 Query: 324 --------------SHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSR 369 + W LF+D ++ + E +TS K+ + Y+LFY+ R Sbjct: 300 ARPAASLGTADRPEPENQWYLFNDT---RVSFSSFESVSNVTSFFPKD--TAYVLFYRQR 354 >6DGF-A nrPDB Length = 370 Score = 107 bits (267), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 101/351 (28%), Positives = 160/351 (45%), Gaps = 44/351 (12%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLA------YKSQPRKKESLLTCLADLFHSIAT 93 GL N GNTC+ NS+LQ L R R+ L +L+ A L +I T Sbjct: 33 GLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWT 92 Query: 94 QKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRL 153 V+ P +F T++++ F Y QQDA EFL +LL+ + + + + K N Sbjct: 93 SSPN-DVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPE- 150 Query: 154 PNGNIDNENNNSTPDPTW----------VHEIFQGTLTNETRCLTCETISSKDEDFLDLS 203 N+D+ ++ W + ++F G L + C C S+ + F DLS Sbjct: 151 ---NLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLS 207 Query: 204 VDVEQN----TSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHL 259 + + + ++ C+R F+ + L + K C CR ++ K+ +++ P IL LHL Sbjct: 208 LPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHL 267 Query: 260 KRFKYMDQLHRYTKLSYRVVFPL-ELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHY 318 KRF + R +KL+ V FPL +L L + + TN +Y+L AV H G+ GHY Sbjct: 268 KRFS--ESRIRTSKLTTFVNFPLRDLDLREFASENTN-HAVYNLYAVSNHSGTTMG-GHY 323 Query: 319 IAIVKSHDF--WLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQ 367 A +S W F+D V + + + TSD Y+LFY+ Sbjct: 324 TAYCRSPGTGEWHTFNDSSVTPMSSSQVR-----TSD-------AYLLFYE 362 >5WCH-A nrPDB Length = 421 Score = 90.9 bits (224), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 91/378 (24%), Positives = 139/378 (36%), Gaps = 104/378 (27%) Query: 38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLA---------------------------- 69 + GL N G TCY NSV+Q LY R +LA Sbjct: 7 FVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRD 66 Query: 70 ----YKSQPRKKESL-------------LTCLADLFHSIATQKKKVGVIPPKKFITRLRK 112 Y Q K +L L L +F +A + + V P+ F + R Sbjct: 67 DVFGYPQQFEDKPALSKTEDRAAYNIGVLRHLQVIFGHLAASRLQYYV--PRGFWKQFRL 124 Query: 113 ENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWV 172 E + Q DA EF N L++++ + L+ + P + Sbjct: 125 WGEPVNLREQHDALEFFNSLVDSLDEALK-----------------------ALGHPAML 161 Query: 173 HEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYY 232 ++ G+ ++ C C +E F L+VD+ + ++ L + + L Y+ Sbjct: 162 SKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYH 221 Query: 233 CEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRL------ 286 CE+C K + KR+ +KKLP +LA+ LKRF Y + K + FP EL + Sbjct: 222 CEKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVA 281 Query: 287 --FNTSGDATNPDRM-----------------YDLVAVVVHCGSGPNRGHYIAIV----- 322 GD NP+ Y LV V+VH G GHY + + Sbjct: 282 GVAKLEGDNVNPESQLIQQSEQSESETAGSTKYRLVGVLVHSGQASG-GHYYSYIIQRNG 340 Query: 323 --KSHDFWLLFDD-DIVE 337 + W FDD D+ E Sbjct: 341 GDGERNRWYKFDDGDVTE 358 >5OHN-A nrPDB Length = 370 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 99/387 (25%), Positives = 154/387 (39%), Gaps = 85/387 (21%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ--------PRKKESLLTCLADLFHSI 91 GLVN GNTC+ NS+LQ L C F + + SQ P + LT L L Sbjct: 8 GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALS 67 Query: 92 ATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQE---- 147 + V+ + LR ++ +QDAHE L + I L++ER ++ Sbjct: 68 CQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHE----LFHVITSSLEDERDRQPRVT 123 Query: 148 --------KQNGRLPNGNIDNENNNSTPDPTWVH----EIFQGTLTNETRCLTCETISSK 195 +Q + I S P PT H F G LT+ C CE S Sbjct: 124 HLFDVHSLEQQSEITPKQITCRTRGS-PHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPV 182 Query: 196 DEDFLD-LSVDVEQNT-----SITHCLRGFSNTETLCSEYKYYCEECRSKQEAH------ 243 D D LS+ + T ++ HCL F ++E++ C+ C +K EA Sbjct: 183 RFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESV---RDVVCDNC-TKIEAKGTLNGE 238 Query: 244 ----------KRMKVKKLPMILALHLKRFKYMDQ---LHRYTKLSYRVVFPLELRLFNTS 290 K++K+ KLP L +HL+R + L R+ + + ++ ++++ Sbjct: 239 KVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEDLDMDEYKYHSN 298 Query: 291 GDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVKS----------HDFWLLFDDDIVEKID 340 ++ L+AVVVH G + GH++ +S + WL DD V K Sbjct: 299 ASTY----LFRLMAVVVHHGDM-HSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKAS 353 Query: 341 AQAIEEFYGLTSDISKNSESGYILFYQ 367 Q + S S Y+LFY+ Sbjct: 354 LQEVL------------SSSAYLLFYE 368 >5OHK-A nrPDB Length = 336 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 93/371 (25%), Positives = 147/371 (39%), Gaps = 87/371 (23%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ--------PRKKESLLTCLADLFHSI 91 GLVN GNTC+ NS+LQ L C F + + SQ P + LT L L Sbjct: 8 GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALS 67 Query: 92 ATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNG 151 + V+ + LR ++ +QDAHE L + I L++ER + Sbjct: 68 CQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHE----LFHVITSSLEDERDGSGSHW 123 Query: 152 RLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLD-LSVDVEQNT 210 + + P F G LT+ C CE S D D LS+ + T Sbjct: 124 K-------------SQHP------FHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAAT 164 Query: 211 -----SITHCLRGFSNTETLCSEYKYYCEECRSKQEAH----------------KRMKVK 249 ++ HCL F ++E++ C+ C +K EA K++K+ Sbjct: 165 WGHPLTLDHCLHHFISSESV---RDVVCDNC-TKIEAKGTLNGEKVEHQRTTFVKQLKLG 220 Query: 250 KLPMILALHLKRFKYMDQ---LHRYTKLSYRVVFPLELRLFNTSGDATNPDRMYDLVAVV 306 KLP L +HL+R + L R+ + + ++ ++++ ++ L+AVV Sbjct: 221 KLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEDLSMDEYKYHSNAST----YLFRLMAVV 276 Query: 307 VHCGSGPNRGHYIAIVKS----------HDFWLLFDDDIVEKIDAQAIEEFYGLTSDISK 356 VH G + GH++ +S + WL DD V K Q + Sbjct: 277 VHHGDM-HSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVL----------- 324 Query: 357 NSESGYILFYQ 367 S S Y+LFY+ Sbjct: 325 -SSSAYLLFYE 334 >5CHV-A nrPDB Length = 323 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 85/344 (24%), Positives = 138/344 (40%), Gaps = 50/344 (14%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFR---EKVLAYKSQPRKKESLLTCLADLFHSIATQKK 96 GL N G TC NS+LQ FR +++ +S +K S+ L L + ++ Sbjct: 8 GLHNIGQTCCLNSLLQVFMMNMDFRMILKRITVPRSAEERKRSVPFQLLLLLEKMQDSRQ 67 Query: 97 KVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNG 156 K + P + + L+K N ++Q DA + + N D + + E+ G Sbjct: 68 KA--VLPTELVQCLQKYNVPL--FVQHDAAQLYLTIWNLTKDQITDTDLTERLQGLFT-- 121 Query: 157 NIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSV-----DVEQNTS 211 W E C+ C SS+ L LS+ D + + Sbjct: 122 -------------IWTQE--------SLICVGCTAESSRRSKLLTLSLPLFDKDAKPLKT 160 Query: 212 ITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRY 271 + LR F + L S CE C K + +K+ LP L +HL RF + R Sbjct: 161 LEDALRCFVQPKELASS-DMCCESCGEKTPWKQVLKLTHLPQTLTIHLMRFSARNS--RT 217 Query: 272 TKLSYRVVFPLEL---RLFNTS---GDATNPDRM-YDLVAVVVHCGSGPNRGHYIAIVKS 324 K+ + V FP L ++ T GD + Y+L AV+ H G + GHY A +++ Sbjct: 218 EKICHSVNFPQSLDFSQVLPTEEDLGDTKEQSEIHYELFAVIAHVGMA-DFGHYCAYIRN 276 Query: 325 --HDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFY 366 W F+D V + + ++ YG + + E+ Y+L Y Sbjct: 277 PVDGKWFCFNDSHVCWVTWKDVQCTYG--NHRYRWRETAYLLVY 318 >2AYN-A nrPDB Length = 404 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 87/402 (21%), Positives = 142/402 (35%), Gaps = 96/402 (23%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTC------LADLFHSIAT 93 GL N GNTCY N+ +Q + ++ + Y R + + L DLF S+ Sbjct: 16 GLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSM-- 73 Query: 94 QKKKVGVIPPKKFITRLRKENELF------DNYMQQDAHEFLNYLLNTIADILQEERKQE 147 K IPP + L F Y+QQDA+E ++ +LQ++ + Sbjct: 74 -DKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMR----VLQQKLEAI 128 Query: 148 KQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCET--ISSKDEDFLDLSVD 205 + + + + + + + F +C E ++ E+ L LS Sbjct: 129 EDDSVKETDSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCF 188 Query: 206 VEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAH--------KRMKVKKLPMILAL 257 + N + + G K +E +KQ K K+ +LP L + Sbjct: 189 I--NQEVKYLFTGL----------KLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTI 236 Query: 258 HLKRFKYMDQLHRYTKLSYRVVFPLELRLF------------------------------ 287 + RF Y ++ K+ V FPL L ++ Sbjct: 237 QMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDKKVNQQP 296 Query: 288 NTSGDATNPDR-------------------MYDLVAVVVHCGSGPNRGHYIAIVK-SHDF 327 NTS ++P + YDL AV+ H G + GHY++ VK D Sbjct: 297 NTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDE 356 Query: 328 WLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSR 369 W+ FDDD V + + I G + Y+L Y R Sbjct: 357 WIKFDDDKVSIVTPEDILRLSG-----GGDWHIAYVLLYGPR 393 >5GJQ-x nrPDB Length = 494 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 87/402 (21%), Positives = 142/402 (35%), Gaps = 96/402 (23%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTC------LADLFHSIAT 93 GL N GNTCY N+ +Q + ++ + Y R + + L DLF S+ Sbjct: 106 GLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSM-- 163 Query: 94 QKKKVGVIPPKKFITRLRKENELF------DNYMQQDAHEFLNYLLNTIADILQEERKQE 147 K IPP + L F Y+QQDA+E ++ +LQ++ + Sbjct: 164 -DKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMR----VLQQKLEAI 218 Query: 148 KQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCET--ISSKDEDFLDLSVD 205 + + + + + + + F +C E ++ E+ L LS Sbjct: 219 EDDSVKETDSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCF 278 Query: 206 VEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAH--------KRMKVKKLPMILAL 257 + N + + G K +E +KQ K K+ +LP L + Sbjct: 279 I--NQEVKYLFTGL----------KLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTI 326 Query: 258 HLKRFKYMDQLHRYTKLSYRVVFPLELRLF------------------------------ 287 + RF Y ++ K+ V FPL L ++ Sbjct: 327 QMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDKKVNQQP 386 Query: 288 NTSGDATNPDR-------------------MYDLVAVVVHCGSGPNRGHYIAIVK-SHDF 327 NTS ++P + YDL AV+ H G + GHY++ VK D Sbjct: 387 NTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDE 446 Query: 328 WLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSR 369 W+ FDDD V + + I G + Y+L Y R Sbjct: 447 WIKFDDDKVSIVTPEDILRLSG-----GGDWHIAYVLLYGPR 483 >6HEH-A nrPDB Length = 382 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 85/336 (25%), Positives = 142/336 (42%), Gaps = 51/336 (15%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAY----------KSQPRKKESL-LTCLADLF 88 GL N GNTC+ ++V+Q+L+ FR VL+Y +S K+ + + L LF Sbjct: 16 GLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNVLENCRSHTEKRNIMFMQELQYLF 75 Query: 89 HSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEK 148 + +K + P + L+ + QQD EF + LL+ + D Q Sbjct: 76 ALMMGSNRK--FVDPSAALDLLKGAFRSSEE-QQQDVSEFTHKLLDWLEDAFQLAV---- 128 Query: 149 QNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQ 208 N+++ N S +P + ++F GT T + +E F + V Sbjct: 129 --------NVNSPRNKSE-NP--MVQLFYGTFL--TEGVREGKPFCNNETFGQYPLQVNG 175 Query: 209 NTSITHCLRGF---SNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYM 265 ++ CL G + E L S++ S + +R KLP +L L RF++ Sbjct: 176 YRNLDECLEGAMVEGDVELLPSDH--------SVKYGQERW-FTKLPPVLTFELSRFEFN 226 Query: 266 DQLHRYTKLSYRVVFPLEL---RLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIV 322 L + K+ ++ FP + R SG + Y L AV+VH G N GHY A + Sbjct: 227 QSLGQPEKIHNKLEFPQIIYMDRYMYGSGSGSR-QVPYRLHAVLVHEGQA-NAGHYWAYI 284 Query: 323 --KSHDFWLLFDDDIVEKIDAQAIE-EFYGLTSDIS 355 + WL ++D V + + +E + YG ++S Sbjct: 285 YNQPRQSWLKYNDISVTESSWEEVERDSYGGLRNVS 320 >5GVI-A nrPDB Length = 444 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 64/269 (23%), Positives = 115/269 (42%), Gaps = 51/269 (18%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ-------PRKKESLLTCLADLFHSIA 92 GL+N GNT + NS+LQ L C F + + SQ ++ L L L +++ Sbjct: 8 GLLNLGNTAFMNSLLQGLAACPSFIRWLEDFTSQNSADRERTERETQLSRSLMQLLKALS 67 Query: 93 TQ-KKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNG 151 + + V+ + LR ++ +QDAHE + L ++ L+EE++++ + Sbjct: 68 SHVPGEDDVLDAGGLLEALRLYRWHISSFEEQDAHELFHVLTSS----LEEEQERQPRVA 123 Query: 152 RLPN-----GNIDNENNNST--------PDPT-W-VHEIFQGTLTNETRCLTCETISSKD 196 L + +++++ N + P P+ W F G LT+ C CE S Sbjct: 124 HLFDMQTLEKSVESKEKNISCRSGGPLHPIPSLWRTRHPFHGRLTSYMACKRCEQQSPVH 183 Query: 197 EDFLDL------SVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAH------- 243 D D S+ + ++ CL+ F ++ET+ + CE C +Q Sbjct: 184 YDSFDSLSLSIPSIQWGRPVTLDQCLQHFISSETI---KEVECENCTKQQAGELVNGEVL 240 Query: 244 --------KRMKVKKLPMILALHLKRFKY 264 K++K+ KLP L +HL+R + Sbjct: 241 ESQRTTFVKQLKLGKLPQCLCIHLQRLTW 269 >3IHP-A nrPDB Length = 854 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 65/316 (20%), Positives = 113/316 (35%), Gaps = 88/316 (27%) Query: 38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVL-----AYKSQPRKK-ESLLTCLADLFHS- 90 Y G+ N GN+CY NSV+Q L+ F+ K + +++ P + T +A L H Sbjct: 344 YTGIRNLGNSCYLNSVVQVLFSIPDFQRKYVDKLEKIFQNAPTDPTQDFSTQVAKLGHGL 403 Query: 91 -----------------IATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLL 133 + QK+ I P+ F + K + F QQDA EF +L+ Sbjct: 404 LSGEYSKPVPESGDGERVPEQKEVQDGIAPRMFKALIGKGHPEFSTNRQQDAQEFFLHLI 463 Query: 134 NTIADILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETIS 193 N + ++N R +EN N E+F+ + + +CL E + Sbjct: 464 NMV-----------ERNCR------SSENPN---------EVFRFLVEEKIKCLATEKVK 497 Query: 194 --------------------------------SKDEDFLDLSVDVEQNTSITHCLRGFSN 221 +E+ + L V + CL + Sbjct: 498 YTQRVDYIMQLPVPMDAALNKEELLEYEEKKRQAEEEKMALPELVRAQVPFSSCLEAYGA 557 Query: 222 TETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKY-MDQLHRYTKLSYRVVF 280 E + ++ ++K A K + P L + +K+F + +D + + KL + Sbjct: 558 PEQVDD---FWSTALQAKSVAVKTTRFASFPDYLVIQIKKFTFGLDWVPK--KLDVSIEM 612 Query: 281 PLELRLFNTSGDATNP 296 P EL + G P Sbjct: 613 PEELDISQLRGTGLQP 628 Score = 31.2 bits (69), Expect = 0.71, Method: Compositional matrix adjust. Identities = 18/68 (26%), Positives = 28/68 (41%), Gaps = 14/68 (20%) Query: 300 YDLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSE 359 Y L A + H G+ GHY+ +K W++++D V + + Sbjct: 797 YQLFAFISHMGTSTMCGHYVCHIKKEGRWVIYNDQKV--------------CASEKPPKD 842 Query: 360 SGYILFYQ 367 GYI FYQ Sbjct: 843 LGYIYFYQ 850 >6H4J-A nrPDB Length = 552 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 77/317 (24%), Positives = 126/317 (39%), Gaps = 66/317 (20%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ------PRKKES-----LLTCLADLF 88 GL N GNTC+ ++V+Q+L+ FR VL YK PR ++ + L LF Sbjct: 16 GLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLF 75 Query: 89 HSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEK 148 + K+K + P + + L+ + D+ QQD EF + LL+ + D Q + ++E Sbjct: 76 ALLVGTKRK--YVDPSRAVEILKDAFKSNDS-QQQDVSEFTHKLLDWLEDAFQMKAEEET 132 Query: 149 QNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKD----EDFLDLSV 204 + N + E+F G R L + K E F + Sbjct: 133 DEEKPKNPMV---------------ELFYG------RFLAVGVLEGKKFENTEMFGQYPL 171 Query: 205 DVEQNTSITHCLRGF---SNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKR 261 V + CL E+L SE +S QE +LP +L L R Sbjct: 172 QVNGFKDLHECLEAAMIEGEIESLHSE-----NSGKSGQEHW----FTELPPVLTFELSR 222 Query: 262 FKYMDQLHRYTKLSYRVVFPLEL---RLFNTSGDATN-----PDRMYDLVAVV------- 306 F++ L R K+ ++ FP L R + + + T R+ D + V+ Sbjct: 223 FEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERY 282 Query: 307 VHCGSGPNRGHYIAIVK 323 + GSGP R + +++ Sbjct: 283 LSYGSGPKRFPLVDVLQ 299 >5O71-A nrPDB Length = 716 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 77/317 (24%), Positives = 126/317 (39%), Gaps = 66/317 (20%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ------PRKKES-----LLTCLADLF 88 GL N GNTC+ ++V+Q+L+ FR VL YK PR ++ + L LF Sbjct: 172 GLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLF 231 Query: 89 HSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEK 148 + K+K + P + + L+ + D+ QQD EF + LL+ + D Q + ++E Sbjct: 232 ALLVGTKRK--YVDPSRAVEILKDAFKSNDS-QQQDVSEFTHKLLDWLEDAFQMKAEEET 288 Query: 149 QNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKD----EDFLDLSV 204 + N + E+F G R L + K E F + Sbjct: 289 DEEKPKNPMV---------------ELFYG------RFLAVGVLEGKKFENTEMFGQYPL 327 Query: 205 DVEQNTSITHCLRGF---SNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKR 261 V + CL E+L SE +S QE +LP +L L R Sbjct: 328 QVNGFKDLHECLEAAMIEGEIESLHSE-----NSGKSGQEHW----FTELPPVLTFELSR 378 Query: 262 FKYMDQLHRYTKLSYRVVFPLEL---RLFNTSGDAT-----NPDRMYDLVAVV------- 306 F++ L R K+ ++ FP L R + + + T R+ D + V+ Sbjct: 379 FEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERY 438 Query: 307 VHCGSGPNRGHYIAIVK 323 + GSGP R + +++ Sbjct: 439 LSYGSGPKRFPLVDVLQ 455 >5MPC-8 nrPDB Length = 499 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 28/96 (29%), Positives = 43/96 (44%), Gaps = 14/96 (14%) Query: 276 YRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVK---SHDFWLLFD 332 Y+ FP L NP +Y+L+ V+ H G+ GHY A ++ + W F+ Sbjct: 412 YKKHFPPNLE------KGENPSCVYNLIGVITHQGANSESGHYQAFIRDELDENKWYKFN 465 Query: 333 DDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQS 368 DD V ++ + IE G S+S IL Y+ Sbjct: 466 DDKVSVVEKEKIESLAG-----GGESDSALILMYKG 496 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 74/333 (22%), Positives = 122/333 (36%), Gaps = 77/333 (23%) Query: 3 ILMTVSKFASICTMGANASALEKEIGPEQ-------FPVNEHYFGLVNFGNTCYCNSVLQ 55 +++ + A++ + A + +++ PEQ PV G N GNTCY N+ LQ Sbjct: 71 VMLLGTPDANLISKPAKKNNFIEDLAPEQQVQQFAQLPV-----GFKNMGNTCYLNATLQ 125 Query: 56 ALYFCRPFREKVLAYKSQPRKKES----------LLTCLADLFHSIATQKKKVGVIPPKK 105 ALY R+ +L Y S ++ + F ++ Q K + P Sbjct: 126 ALYRVNDLRDMILNYNPSQGVSNSGAQDEEIHKQIVIEMKRCFENL--QNKSFKSVLPIV 183 Query: 106 FITRLRKENELFDN-------YMQQDAHEFLNYLLNTIADILQEE-----RKQEKQNGR- 152 + LRK F Y QQDA E L ++++ + ++ R Q K + Sbjct: 184 LLNTLRKCYPQFAERDSQGGFYKQQDAEELFTQLFHSMSIVFGDKFSEDFRIQFKTTIKD 243 Query: 153 LPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSI 212 N N N + H GT TN R E ++ K E DL+ Sbjct: 244 TANDNDITVKENESDSKLQCH--ISGT-TNFMRNGLLEGLNEKIEKRSDLT--------- 291 Query: 213 THCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYT 272 + Y E+ K+ +LP L + RF + ++ + Sbjct: 292 -------------GANSIYSVEK-----------KISRLPKFLTVQYVRFFWKRSTNKKS 327 Query: 273 KLSYRVVFPLELRLFNTSGDATNPDRMYDLVAV 305 K+ +VVFP +L + D P+ + V V Sbjct: 328 KILRKVVFPFQLDV----ADMLTPEYAAEKVKV 356 >1VJV-A nrPDB Length = 415 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 28/96 (29%), Positives = 43/96 (44%), Gaps = 14/96 (14%) Query: 276 YRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVK---SHDFWLLFD 332 Y+ FP L NP +Y+L+ V+ H G+ GHY A ++ + W F+ Sbjct: 328 YKKHFPPNLE------KGENPSCVYNLIGVITHQGANSESGHYQAFIRDELDENKWYKFN 381 Query: 333 DDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQS 368 DD V ++ + IE G S+S IL Y+ Sbjct: 382 DDKVSVVEKEKIESLAG-----GGESDSALILMYKG 412 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 71/298 (23%), Positives = 110/298 (36%), Gaps = 70/298 (23%) Query: 31 QFPVNEHYFGLVNFGNTCYCNSVLQALYFCRPFREKVLAY-------KSQPRKKE---SL 80 Q PV G N GNTCY N+ LQALY R+ +L Y S + +E + Sbjct: 22 QLPV-----GFKNMGNTCYLNATLQALYRVNDLRDMILNYNPSQGVSNSGAQDEEIHKQI 76 Query: 81 LTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDN-------YMQQDAHEFLNYLL 133 + + F ++ Q K + P + LRK F Y QQDA E L Sbjct: 77 VIEMKRCFENL--QNKSFKSVLPVVLLNTLRKCYPQFAERDSQGGFYKQQDAEELFTQLF 134 Query: 134 NTIADILQEE-----RKQEKQNGR-LPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCL 187 ++++ + ++ R Q K + N N N + H GT TN R Sbjct: 135 HSMSIVFGDKFSEDFRIQFKTTIKDTANDNDITVKENESDSKLQCH--ISGT-TNFMRNG 191 Query: 188 TCETISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMK 247 E ++ K E DL+ + Y E+ K Sbjct: 192 LLEGLNEKIEKRSDLT----------------------GANSIYSVEK-----------K 218 Query: 248 VKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDRMYDLVAV 305 + +LP L + RF + ++ +K+ +VVFP +L + D P+ + V V Sbjct: 219 ISRLPKFLTVQYVRFFWKRSTNKKSKILRKVVFPFQLDV----ADMLTPEYAAEKVKV 272 >6H4H-A nrPDB Length = 560 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 62/256 (24%), Positives = 106/256 (41%), Gaps = 43/256 (16%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAY----------KSQPRKKESL-LTCLADLF 88 GL N GNTC+ ++V+Q+L+ FR VL+Y +S K+ + + L LF Sbjct: 16 GLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNVLENCRSHTEKRNIMFMQELQYLF 75 Query: 89 HSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEK 148 + +K + P + L+ + QQD EF + LL+ + D Q Sbjct: 76 ALMMGSNRK--FVDPSAALDLLKGAFRSSEE-QQQDVSEFTHKLLDWLEDAFQLA----- 127 Query: 149 QNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQ 208 N+++ N S +P + ++F GT E + +E F + V Sbjct: 128 -------VNVNSPRNKSE-NP--MVQLFYGTFLTEG--VREGKPFCNNETFGQYPLQVNG 175 Query: 209 NTSITHCLRGF---SNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYM 265 ++ CL G + E L S++ S + +R KLP +L L RF++ Sbjct: 176 YRNLDECLEGAMVEGDVELLPSDH--------SVKYGQERW-FTKLPPVLTFELSRFEFN 226 Query: 266 DQLHRYTKLSYRVVFP 281 L + K+ ++ FP Sbjct: 227 QSLGQPEKIHNKLEFP 242 >3JCR-V nrPDB Length = 565 Score = 35.0 bits (79), Expect = 0.059, Method: Compositional matrix adjust. Identities = 84/349 (24%), Positives = 132/349 (37%), Gaps = 76/349 (21%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLA---YKSQPRKKESLLTCLADLFHSIA---- 92 GL N Y N+VLQAL P R L YK+ R ++ L F + Sbjct: 226 GLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLW 285 Query: 93 -TQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNG 151 + K V P + + + F Q D +FL++ LN + L +K++K Sbjct: 286 NPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKK--- 342 Query: 152 RLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDED------------- 198 T V ++FQG++ T+ L + +++++ Sbjct: 343 ------------------TIVTDVFQGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMV 384 Query: 199 ---FLDLSVDV----------EQ----NTSITHCLRGFSNTETLCSEYKYYCEECRSKQE 241 F+ L++D+ EQ + + L F+ EYK Y K+ Sbjct: 385 ESTFMYLTLDLPTAPLYKDEKEQLIIPQVPLFNILAKFNGITE--KEYKTY------KEN 436 Query: 242 AHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPL---ELRLF-NTSGDATNPD 297 KR ++ KLP L +KRF + K V FP+ +LR + + A + + Sbjct: 437 FLKRFQLTKLPPYLIFCIKRFTKNNFF--VEKNPTIVNFPITNVDLREYLSEEVQAVHKN 494 Query: 298 RMYDLVAVVVHCGSGPNRGHYIAIVKSHDF--WLLFDDDIVEKIDAQAI 344 YDL+A +VH G P+ G Y V H W D V I Q I Sbjct: 495 TTYDLIANIVHDGK-PSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMI 542 >3TF5-A nrPDB Length = 493 Score = 32.7 bits (73), Expect = 0.27, Method: Compositional matrix adjust. Identities = 15/58 (25%), Positives = 29/58 (50%), Gaps = 1/58 (1%) Query: 4 LMTVSKFASIC-TMGANASALEKEIGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFC 60 + +++ +++C GA+ + IG +Q N+ V FG +C+ VL +Y C Sbjct: 230 ISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLC 287 >1BGX-T nrPDB Length = 832 Score = 30.8 bits (68), Expect = 0.92, Method: Compositional matrix adjust. Identities = 15/45 (33%), Positives = 22/45 (48%) Query: 45 GNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFH 89 G +VL+AL P EK+L Y+ + K + + L DL H Sbjct: 510 GKRSTSAAVLEALREAHPIVEKILQYRELTKLKSTYIDPLPDLIH 554 >4N56-A nrPDB Length = 553 Score = 30.8 bits (68), Expect = 0.97, Method: Compositional matrix adjust. Identities = 15/45 (33%), Positives = 22/45 (48%) Query: 45 GNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFH 89 G +VL+AL P EK+L Y+ + K + + L DL H Sbjct: 231 GKRSTSAAVLEALREAHPIVEKILQYRELTKLKSTYIDPLPDLIH 275 >3W7W-A nrPDB Length = 760 Score = 30.8 bits (68), Expect = 0.98, Method: Compositional matrix adjust. Identities = 18/48 (37%), Positives = 25/48 (52%), Gaps = 6/48 (12%) Query: 318 YIAIVKSHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILF 365 Y +V HD+WL D + + E YG T D + N+ESG +LF Sbjct: 416 YPKLVAYHDWWLRNRDH-----NGNGVPE-YGATRDKAHNTESGEMLF 457 >4NQW-A nrPDB Length = 204 Score = 29.3 bits (64), Expect = 2.8, Method: Compositional matrix adjust. Identities = 10/32 (31%), Positives = 19/32 (59%) Query: 201 DLSVDVEQNTSITHCLRGFSNTETLCSEYKYY 232 DL++ ++ +T CL+ ++T+ C E YY Sbjct: 136 DLAIAGDERRRVTECLKALTDTQRQCIELAYY 167 >2EX5-A nrPDB Length = 207 Score = 28.5 bits (62), Expect = 4.3, Method: Compositional matrix adjust. Identities = 19/42 (45%), Positives = 24/42 (57%), Gaps = 5/42 (11%) Query: 115 ELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQ-NGRLPN 155 ELF+N DAH+ L L+N I I + RKQ+ Q N PN Sbjct: 161 ELFNN----DAHQDLEQLVNKILPIWDQMRKQQGQSNEGFPN 198 >2O3J-A nrPDB Length = 481 Score = 27.7 bits (60), Expect = 8.1, Method: Compositional matrix adjust. Identities = 13/58 (22%), Positives = 28/58 (48%), Gaps = 1/58 (1%) Query: 4 LMTVSKFASIC-TMGANASALEKEIGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFC 60 + +++ +++C GA S + +G + ++ V FG +C+ VL +Y C Sbjct: 238 ISSINSISAVCEATGAEISEVAHAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLC 295 >2ESB-A nrPDB Length = 188 Score = 27.3 bits (59), Expect = 9.6, Method: Compositional matrix adjust. Identities = 12/32 (37%), Positives = 19/32 (59%), Gaps = 2/32 (6%) Query: 203 SVDVEQNTSITHCLRGFSNTETLCSEY--KYY 232 SV+++Q ++ HC G S + LC Y KY+ Sbjct: 92 SVEMKQGRTLLHCAAGVSRSAALCLAYLMKYH 123 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5L8W-A nrPDB 499 e-142 5L8H-A nrPDB 466 e-132 5K1A-A nrPDB 434 e-122 2Y6E-A nrPDB 312 1e-85 6CPM-C nrPDB 311 5e-85 6DGF-A nrPDB 299 1e-81 3MTN-A nrPDB 297 5e-81 2GFO-A nrPDB 296 1e-80 4FIP-A nrPDB 285 1e-77 5JTJ-A nrPDB 275 2e-74 5J7T-A nrPDB 274 4e-74 2F1Z-A nrPDB 274 4e-74 5JTV-A nrPDB 274 6e-74 5CHV-A nrPDB 264 3e-71 5GJQ-x nrPDB 260 7e-70 5WCH-A nrPDB 260 1e-69 6HEH-A nrPDB 257 7e-69 5TXK-A nrPDB 257 8e-69 5OHN-A nrPDB 252 1e-67 5OHK-A nrPDB 247 5e-66 2AYN-A nrPDB 241 3e-64 5MPC-8 nrPDB 209 2e-54 5GVI-A nrPDB 198 4e-51 5O71-A nrPDB 191 3e-49 6H4J-A nrPDB 190 7e-49 6H4H-A nrPDB 190 1e-48 1VJV-A nrPDB 170 1e-42 3IHP-A nrPDB 167 8e-42 Sequences not found previously or not previously below threshold: 3JCR-V nrPDB 99 3e-21 2VHF-A nrPDB 54 1e-07 4MSX-A nrPDB 53 3e-07 3WXF-A nrPDB 45 5e-05 3G25-A nrPDB 34 0.11 2GN9-A nrPDB 32 0.49 4C0Q-A nrPDB 31 0.95 3QQC-A nrPDB 30 1.4 >5L8W-A nrPDB Length = 376 Score = 499 bits (1284), Expect = e-142, Method: Composition-based stats. Identities = 370/370 (100%), Positives = 370/370 (100%) Query: 1 MEILMTVSKFASICTMGANASALEKEIGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFC 60 MEILMTVSKFASICTMGANASALEKEIGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFC Sbjct: 7 MEILMTVSKFASICTMGANASALEKEIGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFC 66 Query: 61 RPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDNY 120 RPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDNY Sbjct: 67 RPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDNY 126 Query: 121 MQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTL 180 MQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTL Sbjct: 127 MQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTL 186 Query: 181 TNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQ 240 TNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQ Sbjct: 187 TNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQ 246 Query: 241 EAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDRMY 300 EAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDRMY Sbjct: 247 EAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDRMY 306 Query: 301 DLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSES 360 DLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSES Sbjct: 307 DLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSES 366 Query: 361 GYILFYQSRD 370 GYILFYQSRD Sbjct: 367 GYILFYQSRD 376 >5L8H-A nrPDB Length = 359 Score = 466 bits (1199), Expect = e-132, Method: Composition-based stats. Identities = 318/359 (88%), Positives = 335/359 (93%) Query: 12 SICTMGANASALEKEIGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYK 71 SIC MG NASALEK+IGPEQFP+NEHYFGLVNFGNTCY NSVLQALYFCRPFRE VLAYK Sbjct: 1 SICNMGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYVNSVLQALYFCRPFRENVLAYK 60 Query: 72 SQPRKKESLLTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNY 131 +Q +KKE+LLTCLADLFHSIATQKKKVGVIPPKKFI+RLRKEN+LFDNYMQQDAHEFLNY Sbjct: 61 AQQKKKENLLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNY 120 Query: 132 LLNTIADILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCET 191 LLNTIADILQEE+KQEKQNG+L NGN++ N+ P+ TWVHEIFQGTLTNETRCL CET Sbjct: 121 LLNTIADILQEEKKQEKQNGKLKNGNMNEPAENNKPELTWVHEIFQGTLTNETRCLNCET 180 Query: 192 ISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKL 251 +SSKDEDFLDLSVDVEQNTSITHCLR FSNTETLCSE KYYCE C SKQEA KRM+VKKL Sbjct: 181 VSSKDEDFLDLSVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKL 240 Query: 252 PMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGS 311 PMILALHLKRFKYM+QL RYTKLSYRVVFPLELRLFNTS DA N DRMYDLVAVVVHCGS Sbjct: 241 PMILALHLKRFKYMEQLRRYTKLSYRVVFPLELRLFNTSSDAVNLDRMYDLVAVVVHCGS 300 Query: 312 GPNRGHYIAIVKSHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRD 370 GPNRGHYI IVKSH FWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSR+ Sbjct: 301 GPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRE 359 >5K1A-A nrPDB Length = 331 Score = 434 bits (1115), Expect = e-122, Method: Composition-based stats. Identities = 331/331 (100%), Positives = 331/331 (100%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVG 99 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVG Sbjct: 1 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVG 60 Query: 100 VIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNID 159 VIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNID Sbjct: 61 VIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNID 120 Query: 160 NENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRGF 219 NENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRGF Sbjct: 121 NENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRGF 180 Query: 220 SNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVV 279 SNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVV Sbjct: 181 SNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVV 240 Query: 280 FPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVEKI 339 FPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVEKI Sbjct: 241 FPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVEKI 300 Query: 340 DAQAIEEFYGLTSDISKNSESGYILFYQSRD 370 DAQAIEEFYGLTSDISKNSESGYILFYQSRD Sbjct: 301 DAQAIEEFYGLTSDISKNSESGYILFYQSRD 331 >2Y6E-A nrPDB Length = 367 Score = 312 bits (800), Expect = 1e-85, Method: Composition-based stats. Identities = 94/373 (25%), Positives = 151/373 (40%), Gaps = 53/373 (14%) Query: 34 VNEHYFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPR--------KKESLLTCLA 85 + GL N GNTC+ NS LQ L P + L + + K + A Sbjct: 4 IQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYA 63 Query: 86 DLFHSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERK 145 +L + + + + P+ F T++ + F Y QQD+ E L +LL+ + + L +K Sbjct: 64 ELIKQMWSGR--DAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKK 121 Query: 146 QEKQNGRLPNGNIDNE------NNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDF 199 + + NG D N+ + + + + F G + C C +S + F Sbjct: 122 KPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPF 181 Query: 200 LDLSVDV-------------------EQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQ 240 L++ + + ++ C+ F+ ETL +YC C+ Q Sbjct: 182 CYLTLPLPLKKDRVMEGPMLQPQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQ 241 Query: 241 EAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLE-LRLFNTSGDATNPDRM 299 +A K+ + LP IL +HLKRF Y KL V FP+ L + + + + Sbjct: 242 QATKKFDLWSLPKILVVHLKRFSYNRYW--RDKLDTVVEFPIRGLNMSEFVCNLSARPYV 299 Query: 300 YDLVAVVVHCGSGPNRGHYIAIVKSH--DFWLLFDDDIVEKIDAQAIEEFYGLTSDISKN 357 YDL+AV H G+ GHY A K+ W FDD V I Sbjct: 300 YDLIAVSNHYGAM-GVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIV------------ 346 Query: 358 SESGYILFYQSRD 370 +++ Y+LFYQ RD Sbjct: 347 TKAAYVLFYQRRD 359 >6CPM-C nrPDB Length = 349 Score = 311 bits (795), Expect = 5e-85, Method: Composition-based stats. Identities = 96/351 (27%), Positives = 147/351 (41%), Gaps = 45/351 (12%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRK--------KESLLTCLADLFHSI 91 GL N GNTC+ NS +Q L P E L K Q + + A+L + Sbjct: 21 GLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQM 80 Query: 92 ATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNG 151 + K + P+ F T++ + F Y QQD E L +LL+ + + L RK+ Sbjct: 81 WS--GKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQL 138 Query: 152 RLPNGNIDNE------NNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVD 205 + +G D N+ + + + +IF G + C C IS + F L++ Sbjct: 139 KDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLP 198 Query: 206 V----EQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKR 261 + + + C+ F+ E L +E +YC C+ Q+A K++ + LP +L +HLKR Sbjct: 199 LPMPKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKR 258 Query: 262 FKYMDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAI 321 F Y + KL V FP+ D Y+L+AV H G GHY A Sbjct: 259 FSYSRYM--RDKLDTLVDFPIN--------DLDMSGCRYNLIAVSNHY-GGMGGGHYTAF 307 Query: 322 VKS--HDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRD 370 K+ W FDD V I S++ Y+LFYQ +D Sbjct: 308 AKNKDDGKWYYFDDSSVSTASEDQIV------------SKAAYVLFYQRQD 346 >6DGF-A nrPDB Length = 370 Score = 299 bits (765), Expect = 1e-81, Method: Composition-based stats. Identities = 98/351 (27%), Positives = 157/351 (44%), Gaps = 44/351 (12%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLA------YKSQPRKKESLLTCLADLFHSIAT 93 GL N GNTC+ NS+LQ L R R+ L +L+ A L +I T Sbjct: 33 GLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWT 92 Query: 94 QKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRL 153 V+ P +F T++++ F Y QQDA EFL +LL+ + + + + K N Sbjct: 93 SS-PNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPE- 150 Query: 154 PNGNIDNENNNSTPDPTW----------VHEIFQGTLTNETRCLTCETISSKDEDFLDLS 203 N+D+ ++ W + ++F G L + C C S+ + F DLS Sbjct: 151 ---NLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLS 207 Query: 204 VDVE----QNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHL 259 + + ++ C+R F+ + L + K C CR ++ K+ +++ P IL LHL Sbjct: 208 LPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHL 267 Query: 260 KRFKYMDQLHRYTKLSYRVVFPL-ELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHY 318 KRF + R +KL+ V FPL +L L + + TN +Y+L AV H G+ GHY Sbjct: 268 KRFS--ESRIRTSKLTTFVNFPLRDLDLREFASENTN-HAVYNLYAVSNHSGTTMG-GHY 323 Query: 319 IAIVKSH--DFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQ 367 A +S W F+D V + + + + Y+LFY+ Sbjct: 324 TAYCRSPGTGEWHTFNDSSVTPMSSSQVR------------TSDAYLLFYE 362 >3MTN-A nrPDB Length = 373 Score = 297 bits (760), Expect = 5e-81, Method: Composition-based stats. Identities = 99/365 (27%), Positives = 151/365 (41%), Gaps = 54/365 (14%) Query: 38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKK-----ESLLTCLADLFHSIA 92 + GL N GNTC+ N+VLQ L RP R+ L + + L AD+ ++ Sbjct: 22 HVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALW 81 Query: 93 TQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGR 152 + P +F +K F Y QQDA EFL L+ + L+ R+ + Sbjct: 82 H-PDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLH--LEINRRGRRAPPI 138 Query: 153 LPNGNIDNEN-------------NNSTPDPTW----------VHEIFQGTLTNETRCLTC 189 L NG + + ++ + W + ++F G L + +C C Sbjct: 139 LANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQAC 198 Query: 190 ETISSKDEDFLDLSVDVE------QNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAH 243 S+ E F DLS+ + S+ C F+ E L SE C+ CR K + Sbjct: 199 GYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRST 258 Query: 244 KRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLE-LRLFNTSGDATNPDRMYDL 302 K++ V++ P IL LHL RF K S V FPL+ L L + + D +Y L Sbjct: 259 KKLTVQRFPRILVLHLNRFSA--SRGSIKKSSVGVDFPLQRLSLGDFASD-KAGSPVYQL 315 Query: 303 VAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGY 362 A+ H GS + GHY A+ + W +++D V + + S GY Sbjct: 316 YALCNHSGS-VHYGHYTALCRCQTGWHVYNDSRVSPVSENQVA------------SSEGY 362 Query: 363 ILFYQ 367 +LFYQ Sbjct: 363 VLFYQ 367 >2GFO-A nrPDB Length = 396 Score = 296 bits (757), Expect = 1e-80, Method: Composition-based stats. Identities = 103/353 (29%), Positives = 156/353 (44%), Gaps = 44/353 (12%) Query: 39 FGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPR--------KKESLLTCLADLFHS 90 GL N GNTCY NS+LQ L + Q K + + + Sbjct: 63 TGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKA 122 Query: 91 IATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQN 150 + T + I PK F + K N+ F Y QQD+ E L +L++ + + L + ++ Sbjct: 123 LWT--GQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRK--- 177 Query: 151 GRLPNGNIDNENNNSTPDPTW----------VHEIFQGTLTNETRCLTCETISSKDEDFL 200 R N D+ ++ + W + +FQG + +CLTC S E F+ Sbjct: 178 -RYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 236 Query: 201 DLSVDVEQNT--SITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALH 258 LS+ + + ++ CLR FS E L ++YC CR+++++ K++++ KLP +L +H Sbjct: 237 YLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVH 296 Query: 259 LKRFKYMDQLHRYTKLSYRVVFPLE-LRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGH 317 LKRF Y + + KL V FPLE L L N + Y+L +V H G G + GH Sbjct: 297 LKRFSYDGRWKQ--KLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYG-GLDGGH 353 Query: 318 YIAIVKS--HDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQS 368 Y A K+ W FDD S S S + YILFY S Sbjct: 354 YTAYCKNAARQRWFKFDD------------HEVSDISVSSVKSSAAYILFYTS 394 >4FIP-A nrPDB Length = 476 Score = 285 bits (730), Expect = 1e-77, Method: Composition-based stats. Identities = 105/357 (29%), Positives = 166/357 (46%), Gaps = 51/357 (14%) Query: 40 GLVNFGNTCYCNSVLQAL----YFCRPFREKVLAYKSQPRKKESLLTC-----LADLFHS 90 GL+N GNTC+ +S+LQ L YF R ++ + + R + +C + +L+ + Sbjct: 143 GLINMGNTCFMSSILQCLIHNPYFIRHSMSQIHSNNCKVRSPDKCFSCALDKIVHELYGA 202 Query: 91 IATQKKKVGVIPPKK------FITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEER 144 + T++ + +T K N+ Y QQDAHEF +++N I Sbjct: 203 LNTKQASSSSTSTNRQTGFIYLLTCAWKINQNLAGYSQQDAHEFWQFIINQIH------- 255 Query: 145 KQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSK-DEDFLDLS 203 + LPN + NN + VH +F+G+L + C C+ S + FLDLS Sbjct: 256 --QSYVLDLPNAKEVSRANNKQCECI-VHTVFEGSLESSIVCPGCQNNSKTTIDPFLDLS 312 Query: 204 VDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFK 263 +D++ + CL F E L ++ Y+C EC S Q+A K++ + KLP +L L LKRF+ Sbjct: 313 LDIKDKKKLYECLDSFHKKEQL-KDFNYHCGECNSTQDAIKQLGIHKLPSVLVLQLKRFE 371 Query: 264 YMDQLHRYTKLSYRVVFPLELRLFN---------TSGDATNPDRMYDLVAVVVHCGSGPN 314 ++ KL + FP L + N S + PD +Y+L+ +V H G+ N Sbjct: 372 HLLN-GSNRKLDDFIEFPTYLNMKNYCSTKEKDKHSENGKVPDIIYELIGIVSHKGT-VN 429 Query: 315 RGHYIAIVK-SHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRD 370 GHYIA K S W F+D +V I + + + E Y+LFY R Sbjct: 430 EGHYIAFCKISGGQWFKFNDSMVSSISQEEVLK------------EQAYLLFYTIRQ 474 >5JTJ-A nrPDB Length = 387 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 95/337 (28%), Positives = 145/337 (43%), Gaps = 39/337 (11%) Query: 38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ-PRKKESLLTCLADLFHSIATQKK 96 Y GL N G TCY NS+LQ L+F R+ V ++ +S+ L +F+ + K Sbjct: 22 YVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDK 81 Query: 97 KVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNG 156 + KK E D++MQ D E LL+ + + K G G Sbjct: 82 P---VGTKKLTKSFGWET--LDSFMQHDVQELCRVLLDNVEN---------KMKGTCVEG 127 Query: 157 NIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCL 216 I ++F+G + + +C + S + ED+ D+ + ++ +I Sbjct: 128 TIP--------------KLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESF 173 Query: 217 RGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSY 276 + E L + KY E QEA K +K LP +L L L RF Y Q + K++ Sbjct: 174 VDYVAVEQLDGDNKYDAGE-HGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKIND 232 Query: 277 RVVFPLELRL--FNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIV--KSHDFWLLFD 332 R FP +L L F D +P Y L AV+VH G + GHY+ + K W FD Sbjct: 233 RFEFPEQLPLDEFLQKTDPKDPAN-YILHAVLVHSGDN-HGGHYVVYLNPKGDGKWCKFD 290 Query: 333 DDIVEKIDAQA-IEEFYGLTSDI--SKNSESGYILFY 366 DD+V + + IE YG D ++ + Y+L Y Sbjct: 291 DDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVY 327 >5J7T-A nrPDB Length = 671 Score = 274 bits (700), Expect = 4e-74, Method: Composition-based stats. Identities = 95/337 (28%), Positives = 145/337 (43%), Gaps = 39/337 (11%) Query: 38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ-PRKKESLLTCLADLFHSIATQKK 96 Y GL N G TCY NS+LQ L+F R+ V ++ +S+ L +F+ + K Sbjct: 3 YVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDK 62 Query: 97 KVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNG 156 + KK E D++MQ D E LL+ + + K G G Sbjct: 63 P---VGTKKLTKSFGWET--LDSFMQHDVQELCRVLLDNVEN---------KMKGTCVEG 108 Query: 157 NIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCL 216 I ++F+G + + +C + S + ED+ D+ + ++ +I Sbjct: 109 TIP--------------KLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESF 154 Query: 217 RGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSY 276 + E L + KY E QEA K +K LP +L L L RF Y Q + K++ Sbjct: 155 VDYVAVEQLDGDNKYDAGE-HGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKIND 213 Query: 277 RVVFPLELRL--FNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIV--KSHDFWLLFD 332 R FP +L L F D +P Y L AV+VH G + GHY+ + K W FD Sbjct: 214 RFEFPEQLPLDEFLQKTDPKDPAN-YILHAVLVHSGDN-HGGHYVVYLNPKGDGKWCKFD 271 Query: 333 DDIVEKIDAQA-IEEFYGLTSDI--SKNSESGYILFY 366 DD+V + + IE YG D ++ + Y+L Y Sbjct: 272 DDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVY 308 >2F1Z-A nrPDB Length = 522 Score = 274 bits (700), Expect = 4e-74, Method: Composition-based stats. Identities = 95/337 (28%), Positives = 145/337 (43%), Gaps = 39/337 (11%) Query: 38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ-PRKKESLLTCLADLFHSIATQKK 96 Y GL N G TCY NS+LQ L+F R+ V ++ +S+ L +F+ + K Sbjct: 175 YVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDK 234 Query: 97 KVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNG 156 + KK E D++MQ D E LL+ + + K G G Sbjct: 235 P---VGTKKLTKSFGWET--LDSFMQHDVQELCRVLLDNVEN---------KMKGTCVEG 280 Query: 157 NIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCL 216 I ++F+G + + +C + S + ED+ D+ + ++ +I Sbjct: 281 TIP--------------KLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESF 326 Query: 217 RGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSY 276 + E L + KY E QEA K +K LP +L L L RF Y Q + K++ Sbjct: 327 VDYVAVEQLDGDNKYDAGE-HGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKIND 385 Query: 277 RVVFPLELRL--FNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIV--KSHDFWLLFD 332 R FP +L L F D +P Y L AV+VH G + GHY+ + K W FD Sbjct: 386 RFEFPEQLPLDEFLQKTDPKDPAN-YILHAVLVHSGDN-HGGHYVVYLNPKGDGKWCKFD 443 Query: 333 DDIVEKIDAQA-IEEFYGLTSDI--SKNSESGYILFY 366 DD+V + + IE YG D ++ + Y+L Y Sbjct: 444 DDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVY 480 >5JTV-A nrPDB Length = 594 Score = 274 bits (699), Expect = 6e-74, Method: Composition-based stats. Identities = 95/337 (28%), Positives = 145/337 (43%), Gaps = 39/337 (11%) Query: 38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ-PRKKESLLTCLADLFHSIATQKK 96 Y GL N G TCY NS+LQ L+F R+ V ++ +S+ L +F+ + K Sbjct: 22 YVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDK 81 Query: 97 KVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNG 156 + KK E D++MQ D E LL+ + + K G G Sbjct: 82 P---VGTKKLTKSFGWET--LDSFMQHDVQELCRVLLDNVEN---------KMKGTCVEG 127 Query: 157 NIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCL 216 I ++F+G + + +C + S + ED+ D+ + ++ +I Sbjct: 128 TIP--------------KLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESF 173 Query: 217 RGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSY 276 + E L + KY E QEA K +K LP +L L L RF Y Q + K++ Sbjct: 174 VDYVAVEQLDGDNKYDAGE-HGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKIND 232 Query: 277 RVVFPLELRL--FNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIV--KSHDFWLLFD 332 R FP +L L F D +P Y L AV+VH G + GHY+ + K W FD Sbjct: 233 RFEFPEQLPLDEFLQKTDPKDPAN-YILHAVLVHSGDN-HGGHYVVYLNPKGDGKWCKFD 290 Query: 333 DDIVEKIDAQA-IEEFYGLTSDI--SKNSESGYILFY 366 DD+V + + IE YG D ++ + Y+L Y Sbjct: 291 DDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVY 327 >5CHV-A nrPDB Length = 323 Score = 264 bits (675), Expect = 3e-71, Method: Composition-based stats. Identities = 81/347 (23%), Positives = 133/347 (38%), Gaps = 50/347 (14%) Query: 39 FGLVNFGNTCYCNSVLQALYFCRPFR---EKVLAYKSQPRKKESLLTCLADLFHSIATQK 95 GL N G TC NS+LQ FR +++ +S +K S+ L L + + Sbjct: 7 VGLHNIGQTCCLNSLLQVFMMNMDFRMILKRITVPRSAEERKRSVPFQLLLLLEKMQDSR 66 Query: 96 KKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPN 155 +K + P + + L+K N ++Q DA + + N D + + E+ G Sbjct: 67 QKA--VLPTELVQCLQKYNVPL--FVQHDAAQLYLTIWNLTKDQITDTDLTERLQGLFT- 121 Query: 156 GNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDV-----EQNT 210 W E C+ C SS+ L LS+ + + Sbjct: 122 --------------IWTQE--------SLICVGCTAESSRRSKLLTLSLPLFDKDAKPLK 159 Query: 211 SITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHR 270 ++ LR F + L S CE C K + +K+ LP L +HL RF + R Sbjct: 160 TLEDALRCFVQPKELAS-SDMCCESCGEKTPWKQVLKLTHLPQTLTIHLMRFSARNS--R 216 Query: 271 YTKLSYRVVFPLELRLFN-------TSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVK 323 K+ + V FP L + Y+L AV+ H G + GHY A ++ Sbjct: 217 TEKICHSVNFPQSLDFSQVLPTEEDLGDTKEQSEIHYELFAVIAHVG-MADFGHYCAYIR 275 Query: 324 S--HDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQS 368 + W F+D V + + ++ YG + + E+ Y+L Y Sbjct: 276 NPVDGKWFCFNDSHVCWVTWKDVQCTYG--NHRYRWRETAYLLVYTK 320 >5GJQ-x nrPDB Length = 494 Score = 260 bits (664), Expect = 7e-70, Method: Composition-based stats. Identities = 91/434 (20%), Positives = 153/434 (35%), Gaps = 82/434 (18%) Query: 1 MEILMTVSKFASICTMGANASALEKEIGPEQFP-VNEHYFGLVNFGNTCYCNSVLQALYF 59 M +LM S A + + + +++ EQ E GL N GNTCY N+ +Q + Sbjct: 67 MTLLMMGSADA-LPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATVQCIRS 125 Query: 60 CRPFREKVLAYKSQPRKKESLLT------CLADLFHSIATQKKKVGVIPPKKFITRLRKE 113 ++ + Y R + + L DLF S+ K IPP + L Sbjct: 126 VPELKDALKRYAGALRASGEMASAQYITAALRDLFDSM---DKTSSSIPPIILLQFLHMA 182 Query: 114 NELFDN------YMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNIDNENNNSTP 167 F Y+QQDA+E ++ +LQ++ + + + + + Sbjct: 183 FPQFAEKGEQGQYLQQDANECWIQMMR----VLQQKLEAIEDDSVKETDSSSASAATPSK 238 Query: 168 DPTWVHEIFQGTLTNETRCLTC--ETISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETL 225 + + + F +C E ++ E+ L LS + + + G L Sbjct: 239 KKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFIN--QEVKYLFTGL--KLRL 294 Query: 226 CSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELR 285 E + K K+ +LP L + + RF Y ++ K+ V FPL L Sbjct: 295 QEEITKQSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLD 354 Query: 286 LF------------------------------NTSGDATNPDR----------------- 298 ++ NTS ++P + Sbjct: 355 MYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNN 414 Query: 299 --MYDLVAVVVHCGSGPNRGHYIAIV-KSHDFWLLFDDDIVEKIDAQAIEEFYGLTSDIS 355 YDL AV+ H G + GHY++ V + D W+ FDDD V + + I G Sbjct: 415 CGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSG-----G 469 Query: 356 KNSESGYILFYQSR 369 + Y+L Y R Sbjct: 470 GDWHIAYVLLYGPR 483 >5WCH-A nrPDB Length = 421 Score = 260 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 98/428 (22%), Positives = 150/428 (35%), Gaps = 121/428 (28%) Query: 38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVL----------------------------- 68 + GL N G TCY NSV+Q LY R +L Sbjct: 7 FVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRD 66 Query: 69 ---AYKSQPRKKESL-------------LTCLADLFHSIATQKKKVGVIPPKKFITRLRK 112 Y Q K +L L L +F +A + + V P+ F + R Sbjct: 67 DVFGYPQQFEDKPALSKTEDRAAYNIGVLRHLQVIFGHLAASRLQYYV--PRGFWKQFRL 124 Query: 113 ENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWV 172 E + Q DA EF N L++++ + L+ + P + Sbjct: 125 WGEPVNLREQHDALEFFNSLVDSLDEALK-----------------------ALGHPAML 161 Query: 173 HEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYY 232 ++ G+ ++ C C +E F L+VD+ + ++ L + + L Y+ Sbjct: 162 SKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYH 221 Query: 233 CEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRL------ 286 CE+C K + KR+ +KKLP +LA+ LKRF Y + K + FP EL + Sbjct: 222 CEKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVA 281 Query: 287 --FNTSGDATNPDRM-----------------YDLVAVVVHCGSGPNRGHYIAIV----- 322 GD NP+ Y LV V+VH G GHY + + Sbjct: 282 GVAKLEGDNVNPESQLIQQSEQSESETAGSTKYRLVGVLVHSGQASG-GHYYSYIIQRNG 340 Query: 323 --KSHDFWLLFDDDIVEKIDAQAIEEFYG------------------LTSDISKNSESGY 362 + W FDD V + EE ++ K + Y Sbjct: 341 GDGERNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAY 400 Query: 363 ILFYQSRD 370 ILFY+ D Sbjct: 401 ILFYERMD 408 >6HEH-A nrPDB Length = 382 Score = 257 bits (655), Expect = 7e-69, Method: Composition-based stats. Identities = 88/353 (24%), Positives = 143/353 (40%), Gaps = 56/353 (15%) Query: 34 VNEHYFGLVNFGNTCYCNSVLQALYFCRPFREKVLAY----------KSQPRKKESL-LT 82 V+ GL N GNTC+ ++V+Q+L+ FR VL+Y +S K+ + + Sbjct: 10 VDGWPVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNVLENCRSHTEKRNIMFMQ 69 Query: 83 CLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQE 142 L LF + +K + P + L+ QQD EF + LL+ + D Q Sbjct: 70 ELQYLFALMMGSNRKF--VDPSAALDLLKGAFRS-SEEQQQDVSEFTHKLLDWLEDAFQL 126 Query: 143 ERKQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDL 202 N+++ N S + ++F GT E +E F Sbjct: 127 AV------------NVNSPRNKSENP---MVQLFYGTFLTEGV--REGKPFCNNETFGQY 169 Query: 203 SVDVEQNTSITHCLRGF---SNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHL 259 + V ++ CL G + E L S++ S + +R KLP +L L Sbjct: 170 PLQVNGYRNLDECLEGAMVEGDVELLPSDH--------SVKYGQERW-FTKLPPVLTFEL 220 Query: 260 KRFKYMDQLHRYTKLSYRVVFPLEL---RLFNTSGDATNPDRMYDLVAVVVHCGSGPNRG 316 RF++ L + K+ ++ FP + R SG + Y L AV+VH G N G Sbjct: 221 SRFEFNQSLGQPEKIHNKLEFPQIIYMDRYMYGSGSGSR-QVPYRLHAVLVHEGQA-NAG 278 Query: 317 HYIAIV--KSHDFWLLFDDDIVEKIDAQAIE-EFYGLTSDISKNSESGYILFY 366 HY A + + WL ++D V + + +E + YG ++ S Y L Y Sbjct: 279 HYWAYIYNQPRQSWLKYNDISVTESSWEEVERDSYGGLRNV-----SAYCLMY 326 >5TXK-A nrPDB Length = 372 Score = 257 bits (655), Expect = 8e-69, Method: Composition-based stats. Identities = 104/353 (29%), Positives = 157/353 (44%), Gaps = 39/353 (11%) Query: 39 FGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKV 98 GL+N GNT Y NS+LQAL+ FR VL + L+T L LF + ++ Sbjct: 19 IGLINLGNTSYVNSILQALFMASDFRHCVLRLT--ENNSQPLMTKLQWLFGFLEHSQRPA 76 Query: 99 GVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNI 158 I P+ F++ F QQD E+L YLL+ + + +E+ + + Sbjct: 77 --ISPENFLSA--SWTPWFSPGTQQDCSEYLKYLLDRLHE--EEKTGTRICQKLKQSSSP 130 Query: 159 DNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSV-----DVEQNTSIT 213 P T V ++F G + CL C +SS++E F DLS+ E + S+ Sbjct: 131 SPPEEPPAPSSTSVEKMFGGKIVTRICCLCCLNVSSREEAFTDLSLAFPPPGSEGSRSVL 190 Query: 214 HCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTK 273 + F + E L +E +YYCE C S Q+A K +++ + P L L L RF + + R K Sbjct: 191 DLVNYFLSPEKLTAENRYYCESCASLQDAEKVVELSQGPCYLILTLLRFSFDLRTMRRRK 250 Query: 274 LSYRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVK---------- 323 + V PL LRL G + YDL +VVVH G GHY + Sbjct: 251 ILDDVSIPLLLRLPLAGGRG----QAYDLCSVVVHSGVSSESGHYYCYAREGAARPAASL 306 Query: 324 -------SHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSR 369 + W LF+D ++ + E +TS K+ + Y+LFY+ R Sbjct: 307 GTADRPEPENQWYLFND---TRVSFSSFESVSNVTSFFPKD--TAYVLFYRQR 354 >5OHN-A nrPDB Length = 370 Score = 252 bits (644), Expect = 1e-67, Method: Composition-based stats. Identities = 88/382 (23%), Positives = 148/382 (38%), Gaps = 73/382 (19%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ--------PRKKESLLTCLADLFHSI 91 GLVN GNTC+ NS+LQ L C F + + SQ P + LT L L Sbjct: 8 GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALS 67 Query: 92 ATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERK------ 145 + V+ + LR ++ +QDAHE + + +++ D + + Sbjct: 68 CQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFD 127 Query: 146 --QEKQNGRLPNGNIDNE---NNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFL 200 +Q + I + + T + F G LT+ C CE S D Sbjct: 128 VHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTF 187 Query: 201 D-LSVDVEQNT-----SITHCLRGFSNTETLCSEYKYYCEEC---------------RSK 239 D LS+ + T ++ HCL F ++E++ C+ C + Sbjct: 188 DSLSLSIPAATWGHPLTLDHCLHHFISSESV---RDVVCDNCTKIEAKGTLNGEKVEHQR 244 Query: 240 QEAHKRMKVKKLPMILALHLKRFKYMDQ---LHRYTKLSYRVVFPLELRLFNTSGDATNP 296 K++K+ KLP L +HL+R + L R+ + + ++ ++++ Sbjct: 245 TTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEDLDMDEYKYHSNASTY-- 302 Query: 297 DRMYDLVAVVVHCGSGPNRGHYIAIVKS----------HDFWLLFDDDIVEKIDAQAIEE 346 ++ L+AVVVH G + GH++ +S + WL DD V K Q + Sbjct: 303 --LFRLMAVVVHHGDM-HSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVL- 358 Query: 347 FYGLTSDISKNSESGYILFYQS 368 S S Y+LFY+ Sbjct: 359 -----------SSSAYLLFYER 369 >5OHK-A nrPDB Length = 336 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 85/371 (22%), Positives = 140/371 (37%), Gaps = 85/371 (22%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ--------PRKKESLLTCLADLFHSI 91 GLVN GNTC+ NS+LQ L C F + + SQ P + LT L L Sbjct: 8 GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALS 67 Query: 92 ATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNG 151 + V+ + LR ++ +QDAHE + + +++ D Sbjct: 68 CQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLED------------- 114 Query: 152 RLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLD-LSVDVEQNT 210 + + F G LT+ C CE S D D LS+ + T Sbjct: 115 ----------ERDGSGSHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAAT 164 Query: 211 -----SITHCLRGFSNTETLCSEYKYYCEEC---------------RSKQEAHKRMKVKK 250 ++ HCL F ++E++ C+ C + K++K+ K Sbjct: 165 WGHPLTLDHCLHHFISSESV---RDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGK 221 Query: 251 LPMILALHLKRFKYMDQ---LHRYTKLSYRVVFPLELRLFNTSGDATNPDRMYDLVAVVV 307 LP L +HL+R + L R+ + + ++ ++++ ++ L+AVVV Sbjct: 222 LPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEDLSMDEYKYHSNASTY----LFRLMAVVV 277 Query: 308 HCGSGPNRGHYIAIVKS----------HDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKN 357 H G + GH++ +S + WL DD V K Q + Sbjct: 278 HHGDM-HSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVL------------ 324 Query: 358 SESGYILFYQS 368 S S Y+LFY+ Sbjct: 325 SSSAYLLFYER 335 >2AYN-A nrPDB Length = 404 Score = 241 bits (615), Expect = 3e-64, Method: Composition-based stats. Identities = 86/409 (21%), Positives = 143/409 (34%), Gaps = 81/409 (19%) Query: 26 EIGPEQFP-VNEHYFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLT-- 82 ++ EQ E GL N GNTCY N+ +Q + ++ + Y R + + Sbjct: 1 DMTEEQLASAMELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQ 60 Query: 83 ----CLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDN------YMQQDAHEFLNYL 132 L DLF S+ K IPP + L F Y+QQDA+E + Sbjct: 61 YITAALRDLFDSM---DKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQM 117 Query: 133 LNTIADILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTC--E 190 + +LQ++ + + + + + + + + F +C E Sbjct: 118 MR----VLQQKLEAIEDDSVKETDSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEE 173 Query: 191 TISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKK 250 ++ E+ L LS + + + G L E + K K+ + Sbjct: 174 EVTKGKENQLQLSCFIN--QEVKYLFTGL--KLRLQEEITKQSPTLQRNALYIKSSKISR 229 Query: 251 LPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRLF----------------------- 287 LP L + + RF Y ++ K+ V FPL L ++ Sbjct: 230 LPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLED 289 Query: 288 -------NTSGDATNPDR-------------------MYDLVAVVVHCGSGPNRGHYIAI 321 NTS ++P + YDL AV+ H G + GHY++ Sbjct: 290 KKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSW 349 Query: 322 V-KSHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSR 369 V + D W+ FDDD V + + I G + Y+L Y R Sbjct: 350 VKRKQDEWIKFDDDKVSIVTPEDILRLSG-----GGDWHIAYVLLYGPR 393 >5MPC-8 nrPDB Length = 499 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 67/312 (21%), Positives = 116/312 (37%), Gaps = 63/312 (20%) Query: 3 ILMTVSKFASICTMGANASALEKEIGPEQF--PVNEHYFGLVNFGNTCYCNSVLQALYFC 60 +++ + A++ + A + +++ PEQ + G N GNTCY N+ LQALY Sbjct: 71 VMLLGTPDANLISKPAKKNNFIEDLAPEQQVQQFAQLPVGFKNMGNTCYLNATLQALYRV 130 Query: 61 RPFREKVLAYKSQP----------RKKESLLTCLADLFHSIATQKKKVGVIPPKKFITRL 110 R+ +L Y + ++ + F ++ Q K + P + L Sbjct: 131 NDLRDMILNYNPSQGVSNSGAQDEEIHKQIVIEMKRCFENL--QNKSFKSVLPIVLLNTL 188 Query: 111 RKENELFDN-------YMQQDAHEFLNYLLNTIADILQEE-----RKQEKQNGR-LPNGN 157 RK F Y QQDA E L ++++ + ++ R Q K + N N Sbjct: 189 RKCYPQFAERDSQGGFYKQQDAEELFTQLFHSMSIVFGDKFSEDFRIQFKTTIKDTANDN 248 Query: 158 IDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLR 217 N + H GT TN R E ++ K E DL+ Sbjct: 249 DITVKENESDSKLQCH--ISGT-TNFMRNGLLEGLNEKIEKRSDLT-------------- 291 Query: 218 GFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYR 277 + Y E+ K+ +LP L + RF + ++ +K+ + Sbjct: 292 --------GANSIYSVEK-----------KISRLPKFLTVQYVRFFWKRSTNKKSKILRK 332 Query: 278 VVFPLELRLFNT 289 VVFP +L + + Sbjct: 333 VVFPFQLDVADM 344 Score = 103 bits (257), Expect = 1e-22, Method: Composition-based stats. Identities = 28/107 (26%), Positives = 44/107 (41%), Gaps = 14/107 (13%) Query: 265 MDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVK- 323 + Y+ FP L NP +Y+L+ V+ H G+ GHY A ++ Sbjct: 401 NESEKDQWLEEYKKHFPPNLE------KGENPSCVYNLIGVITHQGANSESGHYQAFIRD 454 Query: 324 --SHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQS 368 + W F+DD V ++ + IE G S+S IL Y+ Sbjct: 455 ELDENKWYKFNDDKVSVVEKEKIESLAG-----GGESDSALILMYKG 496 >5GVI-A nrPDB Length = 444 Score = 198 bits (502), Expect = 4e-51, Method: Composition-based stats. Identities = 88/443 (19%), Positives = 147/443 (33%), Gaps = 130/443 (29%) Query: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQ-------PRKKESLLTCLADLFHSIA 92 GL+N GNT + NS+LQ L C F + + SQ ++ L L L +++ Sbjct: 8 GLLNLGNTAFMNSLLQGLAACPSFIRWLEDFTSQNSADRERTERETQLSRSLMQLLKALS 67 Query: 93 TQ-KKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQE--------E 143 + + V+ + LR ++ +QDAHE + L +++ + + + Sbjct: 68 SHVPGEDDVLDAGGLLEALRLYRWHISSFEEQDAHELFHVLTSSLEEEQERQPRVAHLFD 127 Query: 144 RKQEKQNGRLPNGNIDNENN---NSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFL 200 + +++ NI + + P F G LT+ C CE S D Sbjct: 128 MQTLEKSVESKEKNISCRSGGPLHPIPSLWRTRHPFHGRLTSYMACKRCEQQSPVHYDSF 187 Query: 201 DL------SVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAH----------- 243 D S+ + ++ CL+ F ++ET+ + CE C +Q Sbjct: 188 DSLSLSIPSIQWGRPVTLDQCLQHFISSETI---KEVECENCTKQQAGELVNGEVLESQR 244 Query: 244 ----KRMKVKKLPM--ILALH----------LKR-----FKYMDQLHRYTKLS------- 275 K++K+ KLP + L +KR F L RY S Sbjct: 245 TTFVKQLKLGKLPQCLCIHLQRLTWSKEGSPIKRQEHVQFTEYLSLDRYKHCSAAQSQQK 304 Query: 276 ----------------------------------------YRVVFPLELRLFNTSGDATN 295 + P N + D + Sbjct: 305 TSRTNKAKASADPKDKAIANGVDSEHCNNNKPQSNGTFPSVFLHSPGLSSQLNLTYDYST 364 Query: 296 PDRMYDLVAVVVHCGSGPNRGHYIAIVKS----------HDFWLLFDDDIVEKIDAQAIE 345 + ++ L AV+VH G + GH+I + WL DD V K Q + Sbjct: 365 SEYLFRLTAVLVHHGDM-HSGHFITYRRCPAAPRGTSPFSSQWLWVSDDSVRKASLQEVL 423 Query: 346 EFYGLTSDISKNSESGYILFYQS 368 S S Y+LFY+ Sbjct: 424 ------------SSSAYLLFYER 434 >5O71-A nrPDB Length = 716 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 72/314 (22%), Positives = 121/314 (38%), Gaps = 58/314 (18%) Query: 39 FGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKES-----------LLTCLADL 87 GL N GNTC+ ++V+Q+L+ FR VL YK ++ + L L Sbjct: 171 VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYL 230 Query: 88 FHSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQE 147 F + K+K + P + + L+ + D+ QQD EF + LL+ + D Q + ++E Sbjct: 231 FALLVGTKRK--YVDPSRAVEILKDAFKSNDS-QQQDVSEFTHKLLDWLEDAFQMKAEEE 287 Query: 148 KQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVE 207 + N + E+F G + E F + V Sbjct: 288 TDEEKPKNP---------------MVELFYGRFLA--VGVLEGKKFENTEMFGQYPLQVN 330 Query: 208 QNTSITHCLRGF---SNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKY 264 + CL E+L SE +S QE +LP +L L RF++ Sbjct: 331 GFKDLHECLEAAMIEGEIESLHSEN-----SGKSGQEHW----FTELPPVLTFELSRFEF 381 Query: 265 MDQLHRYTKLSYRVVFPLEL---RLFNTSGDATN-----PDRMYDLVAVV-------VHC 309 L R K+ ++ FP L R + + + T R+ D + V+ + Sbjct: 382 NQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYLSY 441 Query: 310 GSGPNRGHYIAIVK 323 GSGP R + +++ Sbjct: 442 GSGPKRFPLVDVLQ 455 Score = 72.6 bits (176), Expect = 2e-13, Method: Composition-based stats. Identities = 33/161 (20%), Positives = 53/161 (32%), Gaps = 24/161 (14%) Query: 224 TLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALH----------LKRFKYMDQLHRYTK 273 L S S+ HK ++P L +H L + R Sbjct: 502 ELPSTSPSSVAAISSRSVIHKPFTQSRIPPDLPMHPAPRHITEEELSVLESCLHRWRTEI 561 Query: 274 LSYRVVFPLELRLFNTS-----GDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVKSH--D 326 + + + + D + Y L AV+VH G N GHY A + H Sbjct: 562 ENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQA-NAGHYWAYIFDHRES 620 Query: 327 FWLLFDDDIVEKIDAQA-IEEFYGLTSDISKNSESGYILFY 366 W+ ++D V K + + + +G + S Y L Y Sbjct: 621 RWMKYNDIAVTKSSWEELVRDSFGGYRNA-----SAYCLMY 656 >6H4J-A nrPDB Length = 552 Score = 190 bits (483), Expect = 7e-49, Method: Composition-based stats. Identities = 72/314 (22%), Positives = 121/314 (38%), Gaps = 58/314 (18%) Query: 39 FGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKES-----------LLTCLADL 87 GL N GNTC+ ++V+Q+L+ FR VL YK ++ + L L Sbjct: 15 VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYL 74 Query: 88 FHSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQE 147 F + K+K + P + + L+ + D+ QQD EF + LL+ + D Q + ++E Sbjct: 75 FALLVGTKRK--YVDPSRAVEILKDAFKSNDS-QQQDVSEFTHKLLDWLEDAFQMKAEEE 131 Query: 148 KQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVE 207 + N + E+F G + E F + V Sbjct: 132 TDEEKPKNP---------------MVELFYGRFLA--VGVLEGKKFENTEMFGQYPLQVN 174 Query: 208 QNTSITHCLRGF---SNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKY 264 + CL E+L SE +S QE +LP +L L RF++ Sbjct: 175 GFKDLHECLEAAMIEGEIESLHSEN-----SGKSGQEHW----FTELPPVLTFELSRFEF 225 Query: 265 MDQLHRYTKLSYRVVFPLEL---RLFNTSGDATN-----PDRMYDLVAVV-------VHC 309 L R K+ ++ FP L R + + + T R+ D + V+ + Sbjct: 226 NQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYLSY 285 Query: 310 GSGPNRGHYIAIVK 323 GSGP R + +++ Sbjct: 286 GSGPKRFPLVDVLQ 299 Score = 72.2 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 33/161 (20%), Positives = 53/161 (32%), Gaps = 24/161 (14%) Query: 224 TLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALH----------LKRFKYMDQLHRYTK 273 L S S+ HK ++P L +H L + R Sbjct: 346 ELPSTSPSSVAAISSRSVIHKPFTQSRIPPDLPMHPAPRHITEEELSVLESCLHRWRTEI 405 Query: 274 LSYRVVFPLELRLFNTS-----GDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVKSH--D 326 + + + + D + Y L AV+VH G N GHY A + H Sbjct: 406 ENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQA-NAGHYWAYIFDHRES 464 Query: 327 FWLLFDDDIVEKIDAQA-IEEFYGLTSDISKNSESGYILFY 366 W+ ++D V K + + + +G + S Y L Y Sbjct: 465 RWMKYNDIAVTKSSWEELVRDSFGGYRNA-----SAYCLMY 500 >6H4H-A nrPDB Length = 560 Score = 190 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 62/267 (23%), Positives = 106/267 (39%), Gaps = 43/267 (16%) Query: 34 VNEHYFGLVNFGNTCYCNSVLQALYFCRPFREKVLAY----------KSQPRKKESL-LT 82 V+ GL N GNTC+ ++V+Q+L+ FR VL+Y +S K+ + + Sbjct: 10 VDGWPVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNVLENCRSHTEKRNIMFMQ 69 Query: 83 CLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQE 142 L LF + +K + P + L+ QQD EF + LL+ + D Q Sbjct: 70 ELQYLFALMMGSNRKF--VDPSAALDLLKGAFRS-SEEQQQDVSEFTHKLLDWLEDAFQL 126 Query: 143 ERKQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDL 202 N+++ N S + ++F GT E +E F Sbjct: 127 AV------------NVNSPRNKSENP---MVQLFYGTFLTEGV--REGKPFCNNETFGQY 169 Query: 203 SVDVEQNTSITHCLRGF---SNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHL 259 + V ++ CL G + E L S++ S + +R KLP +L L Sbjct: 170 PLQVNGYRNLDECLEGAMVEGDVELLPSDH--------SVKYGQERW-FTKLPPVLTFEL 220 Query: 260 KRFKYMDQLHRYTKLSYRVVFPLELRL 286 RF++ L + K+ ++ FP + + Sbjct: 221 SRFEFNQSLGQPEKIHNKLEFPQIIYM 247 Score = 73.3 bits (178), Expect = 2e-13, Method: Composition-based stats. Identities = 24/78 (30%), Positives = 35/78 (44%), Gaps = 9/78 (11%) Query: 292 DATNPDRMYDLVAVVVHCGSGPNRGHYIAIV--KSHDFWLLFDDDIVEKIDAQAIE-EFY 348 D Y L AV+VH G N GHY A + + WL ++D V + + +E + Y Sbjct: 429 DPLLRQVPYRLHAVLVHDGQA-NAGHYWAYIYNQPRQSWLKYNDISVTESSWEEVERDSY 487 Query: 349 GLTSDISKNSESGYILFY 366 G ++ S Y L Y Sbjct: 488 GGLRNV-----SAYCLMY 500 >1VJV-A nrPDB Length = 415 Score = 170 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 65/282 (23%), Positives = 102/282 (36%), Gaps = 66/282 (23%) Query: 31 QFPVNEHYFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQP----------RKKESL 80 Q PV G N GNTCY N+ LQALY R+ +L Y + + Sbjct: 22 QLPV-----GFKNMGNTCYLNATLQALYRVNDLRDMILNYNPSQGVSNSGAQDEEIHKQI 76 Query: 81 LTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDN-------YMQQDAHEFLNYLL 133 + + F ++ Q K + P + LRK F Y QQDA E L Sbjct: 77 VIEMKRCFENL--QNKSFKSVLPVVLLNTLRKCYPQFAERDSQGGFYKQQDAEELFTQLF 134 Query: 134 NTIADILQEE-----RKQEKQNGR-LPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCL 187 ++++ + ++ R Q K + N N N + H GT TN R Sbjct: 135 HSMSIVFGDKFSEDFRIQFKTTIKDTANDNDITVKENESDSKLQCH--ISGT-TNFMRNG 191 Query: 188 TCETISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMK 247 E ++ K E DL+ + Y E+ K Sbjct: 192 LLEGLNEKIEKRSDLT----------------------GANSIYSVEK-----------K 218 Query: 248 VKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRLFNT 289 + +LP L + RF + ++ +K+ +VVFP +L + + Sbjct: 219 ISRLPKFLTVQYVRFFWKRSTNKKSKILRKVVFPFQLDVADM 260 Score = 102 bits (253), Expect = 3e-22, Method: Composition-based stats. Identities = 28/107 (26%), Positives = 44/107 (41%), Gaps = 14/107 (13%) Query: 265 MDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVK- 323 + Y+ FP L NP +Y+L+ V+ H G+ GHY A ++ Sbjct: 317 NESEKDQWLEEYKKHFPPNLE------KGENPSCVYNLIGVITHQGANSESGHYQAFIRD 370 Query: 324 --SHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQS 368 + W F+DD V ++ + IE G S+S IL Y+ Sbjct: 371 ELDENKWYKFNDDKVSVVEKEKIESLAG-----GGESDSALILMYKG 412 >3IHP-A nrPDB Length = 854 Score = 167 bits (422), Expect = 8e-42, Method: Composition-based stats. Identities = 64/317 (20%), Positives = 108/317 (34%), Gaps = 86/317 (27%) Query: 38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLA-----YKSQPRKKES-LLTCLADLFHSI 91 Y G+ N GN+CY NSV+Q L+ F+ K + +++ P T +A L H + Sbjct: 344 YTGIRNLGNSCYLNSVVQVLFSIPDFQRKYVDKLEKIFQNAPTDPTQDFSTQVAKLGHGL 403 Query: 92 ------------------ATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLL 133 QK+ I P+ F + K + F QQDA EF +L+ Sbjct: 404 LSGEYSKPVPESGDGERVPEQKEVQDGIAPRMFKALIGKGHPEFSTNRQQDAQEFFLHLI 463 Query: 134 NTIADILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETIS 193 N + ++N R +EN N E+F+ + + +CL E + Sbjct: 464 NMV-----------ERNCR------SSENPN---------EVFRFLVEEKIKCLATEKVK 497 Query: 194 --------------------------------SKDEDFLDLSVDVEQNTSITHCLRGFSN 221 +E+ + L V + CL + Sbjct: 498 YTQRVDYIMQLPVPMDAALNKEELLEYEEKKRQAEEEKMALPELVRAQVPFSSCLEAYGA 557 Query: 222 TETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFP 281 E + ++ ++K A K + P L + +K+F + KL + P Sbjct: 558 PEQVD---DFWSTALQAKSVAVKTTRFASFPDYLVIQIKKFTFGLDW-VPKKLDVSIEMP 613 Query: 282 LELRLFNTSGDATNPDR 298 EL + G P Sbjct: 614 EELDISQLRGTGLQPGE 630 Score = 54.8 bits (130), Expect = 6e-08, Method: Composition-based stats. Identities = 18/69 (26%), Positives = 28/69 (40%), Gaps = 14/69 (20%) Query: 300 YDLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSE 359 Y L A + H G+ GHY+ +K W++++D V + + Sbjct: 797 YQLFAFISHMGTSTMCGHYVCHIKKEGRWVIYNDQKVCASEK--------------PPKD 842 Query: 360 SGYILFYQS 368 GYI FYQ Sbjct: 843 LGYIYFYQR 851 >3JCR-V nrPDB Length = 565 Score = 98.8 bits (244), Expect = 3e-21, Method: Composition-based stats. Identities = 75/352 (21%), Positives = 122/352 (34%), Gaps = 40/352 (11%) Query: 39 FGLVNFGNTCYCNSVLQALYFCRPFREKVL---AYKSQPRKKESLLTCL----ADLFHSI 91 GL N Y N+VLQAL P R L YK+ R ++ L +L + Sbjct: 225 VGLNNIKANDYANAVLQALSNVPPLRNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKL 284 Query: 92 ATQKKKVGVIPPKKFITRLRKENEL-FDNYMQQDAHEFLNYLLNTIADILQEERKQEKQN 150 + + P + + + ++ F Q D +FL++ LN + L +K++K Sbjct: 285 WNPRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKKTI 344 Query: 151 GRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNT 210 P P E + + + F+ L++D+ Sbjct: 345 VTDVFQGSMRIFTKKLPHPDLPAEE-----KEQLLHNDEYQETMVESTFMYLTLDLPTAP 399 Query: 211 SITHCLRGFSNTET-----LCSEYKYYCEECRSKQEA-HKRMKVKKLPMILALHLKRFKY 264 + L +E ++ +E KR ++ KLP L +KRF Sbjct: 400 LYKDEKEQLIIPQVPLFNILAKFNGITEKEYKTYKENFLKRFQLTKLPPYLIFCIKRFTK 459 Query: 265 MDQLHRYTKLSYRVVFPL---ELRLFNTSG-DATNPDRMYDLVAVVVHCGSGPNRGHYIA 320 + K V FP+ +LR + + A + + YDL+A +VH G P+ G Y Sbjct: 460 NNFF--VEKNPTIVNFPITNVDLREYLSEEVQAVHKNTTYDLIANIVHDGK-PSEGSYRI 516 Query: 321 IV--KSHDFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESGYILFYQSRD 370 V W D V I Q I YI ++ RD Sbjct: 517 HVLHHGTGKWYELQDLQVTDILPQMI------------TLSEAYIQIWKRRD 556 >2VHF-A nrPDB Length = 374 Score = 53.7 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 58/322 (18%), Positives = 101/322 (31%), Gaps = 66/322 (20%) Query: 46 NTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVGVIPPKK 105 N+CY +S L L+ + VL + E L I + G + K Sbjct: 17 NSCYLDSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGYVCATK 76 Query: 106 FITRLRKENELF---DNY--MQQDAHEFLNYLLNTI--ADILQEERKQEKQNGRLPNGNI 158 + LRK E + ++D EFLN L + I + L + R ++ I Sbjct: 77 IMK-LRKILEKVEAASGFTSEEKDPEEFLNILFHHILRVEPLLKIRSAGQKVQDCYFYQI 135 Query: 159 DNENNNSTPDPTWVHEIFQGTLTNETRCLTCE--------------TISSKDEDFLDLS- 203 E N PT + + + + + K L+L+ Sbjct: 136 FMEKNEKVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNI 195 Query: 204 ----------VDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPM 253 + ++ C + + + + K +C+ C ++ Sbjct: 196 TDLLEDTPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCNTQ-------------- 241 Query: 254 ILALHLKRFKYMDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGP 313 + LH KR + V P +L ++ P + +L AV+ Sbjct: 242 -VHLHPKRLNHKY---------NPVSLPKDLPDWDWR-HGCIPCQNMELFAVL-----CI 285 Query: 314 NRGHYIAIV---KSHDFWLLFD 332 HY+A V K WL FD Sbjct: 286 ETSHYVAFVKYGKDDSAWLFFD 307 >4MSX-A nrPDB Length = 482 Score = 52.5 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 49/319 (15%), Positives = 93/319 (29%), Gaps = 49/319 (15%) Query: 38 YFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKK 97 + G N Y +SVL + P R+ L + + + L+ I + K Sbjct: 183 FIGFTNAATYDYAHSVLLLISHMVPVRDHFLL--NHFDNQGEFIKRLSICVKKIWSPKLF 240 Query: 98 VGVIPPKKFITRLR-KENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNG 156 + F++ L+ +E + D FL +L N I + + + + Sbjct: 241 KHHLSVDDFVSYLKVREGLNLNPI---DPRLFLLWLFNKICSSSNDLKSILNHSCKGKVK 297 Query: 157 NIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCL 216 I N + ++ + F L++D+ + + Sbjct: 298 -IAKVENKPEASESVTGKVIV-------------------KPFWVLTLDLPEFSPFEDG- 336 Query: 217 RGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSY 276 + + ++ +LP L H RF + Sbjct: 337 NSVDDLPQINITKLLTKFTKSRSSSTSTVFELTRLPQFLIFHFNRFDRNSDHPVKNRNQT 396 Query: 277 RVVFPLELRLFNTSGDATNPDRMYDLVAVVVHC--------GSGPNR---GHYIA--IVK 323 V F EL + + Y L A VVH G+ N H+I Sbjct: 397 LVEFSSELEILHVK---------YRLKANVVHVVIKQPSTDGNAFNGDEKSHWITQLYDN 447 Query: 324 SHDFWLLFDDDIVEKIDAQ 342 + W+ D + +A+ Sbjct: 448 KSEKWIEIDGINTTEREAE 466 >3WXF-A nrPDB Length = 312 Score = 44.8 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 26/130 (20%), Positives = 46/130 (35%), Gaps = 19/130 (14%) Query: 210 TSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLH 269 + C + ++ + +K + P L + + RF Sbjct: 128 QKVQDCYFYQIFMDKKDKVMVPTSQQLLEWSFINSDLKFAEAPSCLIIQMPRF------G 181 Query: 270 RYTKLSYRVVFP-LELRLFNTSGDA---TNPDRMYDLVAVVVHCGSGPNRGHYIAIVK-- 323 + K+ ++ FP LEL + + D P + +L AV+ HY+A VK Sbjct: 182 KDFKMFNKI-FPSLELDITDLLDDTPLEGGPHQQMELFAVL-----CIETSHYVAFVKYG 235 Query: 324 -SHDFWLLFD 332 + WL FD Sbjct: 236 SADSAWLFFD 245 Score = 32.1 bits (71), Expect = 0.43, Method: Composition-based stats. Identities = 23/96 (23%), Positives = 34/96 (35%), Gaps = 6/96 (6%) Query: 46 NTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVGVIPPKK 105 N+ Y +S L L+ + VL E L I + G + K Sbjct: 20 NSSYLDSTLFCLFSFSSVLDTVLLRPRSKTDVEYYKETQELLRTEIVNPLRIHGYVCATK 79 Query: 106 FITRLRKENELF---DNY--MQQDAHEFLNYLLNTI 136 + LR+ E + Q+D EFLN L + I Sbjct: 80 IMK-LRRILEKVEAASGFTSEQKDPEEFLNILFHHI 114 >3G25-A nrPDB Length = 501 Score = 34.0 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 9/61 (14%), Positives = 25/61 (40%), Gaps = 5/61 (8%) Query: 89 HSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEK 148 + QK ++ + ++F +++ DA+E +L + +++ E + Sbjct: 20 AILFNQKGEIAGVAQREFKQ----YFPQ-SGWVEHDANEIWTSVLAVMTEVINENDVRAD 74 Query: 149 Q 149 Q Sbjct: 75 Q 75 >2GN9-A nrPDB Length = 344 Score = 31.7 bits (70), Expect = 0.49, Method: Composition-based stats. Identities = 33/231 (14%), Positives = 73/231 (31%), Gaps = 18/231 (7%) Query: 34 VNEHYFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFHSIAT 93 + + G N N C N++ Q + + + L A+ F + Sbjct: 115 IKTNIMGASNVINACLKNAISQVIALSTDKAANPINLYGATKLCSDKLFVSANNFKG--S 172 Query: 94 QKKKVGVIPPKKFITRLRKENELFDNYMQQDAHE----------FLNYLLNTIADILQEE 143 + + V+ + F +Q A E F L ++ +L+ Sbjct: 173 SQTQFSVVRYGNVVGSRGSVVPFFKKLVQNKASEIPITDIRMTRFWITLDEGVSFVLKSL 232 Query: 144 RK---QEKQNGRLPNGNIDNENNNSTPD-PTWVHEIFQG-TLTNETRCLTCETISSKDED 198 ++ E ++P+ + + P+ PT + I G L ++ + ED Sbjct: 233 KRMHGGEIFVPKIPSMKMTDLAKALAPNTPTKIIGIRPGEKLHEVMIPKDESHLALEFED 292 Query: 199 FLDLSVDVEQNTSITHCLRGFS-NTETLCSEYKYYCEECRSKQEAHKRMKV 248 F + + T + L + + +++Y E +K+ Sbjct: 293 FFIIQPTISFQTPKDYTLTKLHEKGQKVAPDFEYSSHNNNQWLEPDDLLKL 343 >4C0Q-A nrPDB Length = 923 Score = 31.0 bits (68), Expect = 0.95, Method: Composition-based stats. Identities = 12/81 (14%), Positives = 27/81 (33%), Gaps = 4/81 (4%) Query: 77 KESLLTCLADLFHSIATQKKKVGVIPPKKFITRL----RKENELFDNYMQQDAHEFLNYL 132 E + L ++ + P F+ RL R N + +N + + + Sbjct: 582 SELCSVQVMALKKLLSQEPSNGISSDPTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQEI 641 Query: 133 LNTIADILQEERKQEKQNGRL 153 +++ L + R + R Sbjct: 642 WPVLSETLNKHRADNRIVERC 662 >3QQC-A nrPDB Length = 436 Score = 30.2 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 10/59 (16%), Positives = 18/59 (30%) Query: 186 CLTCETISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHK 244 C C I DE+ + +E + ++ + C C + Q K Sbjct: 161 CRECGRIKLTDEEIEEYMKKIELARNRRSEFNEIIKEIHKKAKERMVCPHCGAPQYPIK 219 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.120 0.318 Lambda K H 0.267 0.0368 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,496,963 Number of Sequences: 36641 Number of extensions: 460550 Number of successful extensions: 1508 Number of sequences better than 10.0: 36 Number of HSP's better than 10.0 without gapping: 64 Number of HSP's successfully gapped in prelim test: 15 Number of HSP's that attempted gapping in prelim test: 1203 Number of HSP's gapped (non-prelim): 112 length of query: 370 length of database: 10,336,785 effective HSP length: 98 effective length of query: 272 effective length of database: 6,745,967 effective search space: 1834903024 effective search space used: 1834903024 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 59 (27.5 bits)