BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= O75191 (536 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4BC2-A nrPDB 1116 0.0 5VM1-A nrPDB 69 5e-12 3I8B-A nrPDB 68 1e-11 3LL3-A nrPDB 66 3e-11 2ITM-A nrPDB 48 1e-05 5YA1-A nrPDB 43 4e-04 2DPN-A nrPDB 39 0.004 3IFR-A nrPDB 35 0.055 5AZI-A nrPDB 33 0.21 5W7B-C nrPDB 32 0.90 3FLC-O nrPDB 31 1.5 3FII-A nrPDB 30 2.1 2C5S-A nrPDB 30 3.7 2A8A-A nrPDB 28 6.8 3HZ4-A nrPDB 28 6.9 >4BC2-A nrPDB Length = 538 Score = 1116 bits (2886), Expect = 0.0, Method: Compositional matrix adjust. Identities = 536/536 (100%), Positives = 536/536 (100%) Query: 1 MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLT 60 MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLT Sbjct: 3 MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLT 62 Query: 61 VTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLR 120 VTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLR Sbjct: 63 VTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLR 122 Query: 121 LHQQLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIY 180 LHQQLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIY Sbjct: 123 LHQQLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIY 182 Query: 181 QQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPH 240 QQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPH Sbjct: 183 QQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPH 242 Query: 241 LEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLG 300 LEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLG Sbjct: 243 LEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLG 302 Query: 301 TSDTLFLWLQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSK 360 TSDTLFLWLQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSK Sbjct: 303 TSDTLFLWLQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSK 362 Query: 361 ALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKR 420 ALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKR Sbjct: 363 ALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKR 422 Query: 421 IHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHG 480 IHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHG Sbjct: 423 IHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHG 482 Query: 481 LAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEALLPQYAKLEQRILSQTRGPPE 536 LAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEALLPQYAKLEQRILSQTRGPPE Sbjct: 483 LAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEALLPQYAKLEQRILSQTRGPPE 538 >5VM1-A nrPDB Length = 491 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 115/523 (21%), Positives = 194/523 (37%), Gaps = 61/523 (11%) Query: 11 LGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMWVQ 70 LG D T VK + +D N D P G + P W++ Sbjct: 11 LGLDLGTSGVKALLIDEAQNPVGAAHGELDVSRPH-----------PGWSEQDPA-QWIK 58 Query: 71 ALDIILEKMKASG-FDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQDCF 129 A +E ++A+ +FS + + +GQ HG+ T L + R+ Sbjct: 59 ACRTAIEALRAAHPKEFSAITGIGLSGQMHGA-----------TLLDAEDRV-------- 99 Query: 130 SISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSH 189 + C +W D+ + + +L+A A +TG+ + FT ++ + + + ++ Sbjct: 100 -LRPCILWNDTRSYREAAELDAD----PAFRAITGNIVFPGFTAPKLVWVARNEADIFAR 154 Query: 190 TERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKLSPPV 249 ++ L + G Y D SD +G + L + WS L E ++ V Sbjct: 155 IRKVLLPKDYLRLWLTGEYIS-DMSDSAGTSWLDTGARRWSAELLAKTGLG-EGQMPQLV 212 Query: 250 PSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGM-RLEEGDIAVSLGTSDTLFL- 307 G + + + V GDN AS GM ++ G VSLGTS LF Sbjct: 213 EGSEAAGCLRAELAAEWSLTASVIVAGGAGDNAASACGMGTVKPGHAFVSLGTSGVLFAA 272 Query: 308 -WLQEPMPALEGHIFCNPV-DSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSKALQST 365 +P P H FC+ + + H M ++ +L + ++ V + + L T Sbjct: 273 NGAYQPKPESAVHAFCHALPRTWHQMGVILSAASAL---EWYSKIVGATPQSLDRELGET 329 Query: 366 EMGNGGNLGFYFDVMEITP--EIIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKRIHA 423 G + E TP + R F H+ +A++EG A R + Sbjct: 330 LKAPGSVTFLPYLSGERTPYNDAKIRGSFCGLEHEADR---SALTQAVLEGVAFAIRDNL 386 Query: 424 EGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHGLAG 483 L T + A GG S + L+ +A + P+ + + + A R A Sbjct: 387 LALQSAGTEITSLTAVGGGSRSTYWLKAIATALNVPIALPEEGDFGAAFGAARLGLIAAT 446 Query: 484 GTDVPFSEVVKLAPNPRLAATPSPGASQVYEALLPQYAKLEQR 526 G D PF+ + P+ A T P +ALL Y + QR Sbjct: 447 GAD-PFT----ICTPPQTARTIEP-----EQALLSAYDEAYQR 479 >3I8B-A nrPDB Length = 515 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 130/529 (24%), Positives = 186/529 (35%), Gaps = 99/529 (18%) Query: 7 RRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVL 66 R G D STQ KV DAE E V F G H +G +V Sbjct: 4 RTLVAGVDTSTQSCKVRVTDAETG----ELVRF-----------GQAKHPNGTSVDPS-- 46 Query: 67 MWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQ 126 W A E+ A G D V AL+ GQQHG + L Q Sbjct: 47 YWWSAFQEAAEQ--AGGLD--DVSALAVGGQQHGMVI-----------------LDNQGN 85 Query: 127 DCFSISDCPVWMDSSTTAQCRQLEAAVG---------------GAQALSCLTGSRAYERF 171 I D +W D+S+ Q L +G G Q GS + Sbjct: 86 ---VIRDAMLWNDTSSAPQAAALIEKLGAAPAQDGEPEDPIARGKQRWVKAVGSSPVASY 142 Query: 172 TGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPI-------------DYSDGSG 218 T ++A + + PE I L + S + Y P+ D SD SG Sbjct: 143 TLTKVAWVAENEPENVKKIAAICLPHDWL-SWRIAGYGPVAEGEDAHLEALFTDRSDASG 201 Query: 219 MNLLQIQDKVWS--------QACLGACAP--HLEEKLSPPVPSCSVVGAISSY-YVQRYG 267 + +A GA A H E + P V + + + Sbjct: 202 TIYYDAASNEYRRDLIAMVLEAAEGAKAAQSHAEAIVLPTVLGPRDAAPVKADPAIAGKN 261 Query: 268 FPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQEPMPALEGHIFCNPVDS 327 GC + GDN + G+ + GD+++SLGTS + P L G + + Sbjct: 262 VEGGCLLAPGGGDNAMASLGLGMAVGDVSISLGTSGVAAAISENPTYDLTGAVSGFADCT 321 Query: 328 QHYMALLCFKNGSLMREKIRNESVSRSWSDFSK-ALQSTEMGNGGNLGFYFDVMEITPE- 385 HY+ L C NGS + + R ++ + + +K A S NG L YFD E TP Sbjct: 322 GHYLPLACTINGSRILDAGR-AALGVDYDELAKLAFASKPGANGITLVPYFD-GERTPNR 379 Query: 386 ------IIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKRIHAEGLGYRVMSKTKILAT 439 G NT +A RA +EG ++R E + S T+IL Sbjct: 380 PNATATFSGMTLANTTRENLA--------RAFVEGLLCSQRDCLELIRSLGASITRILLI 431 Query: 440 GGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHGLAGGTDVP 488 GG + + I + + V T +G+A +A L+G T+ P Sbjct: 432 GGGAKSEAIRTLAPSILGMDVTRPATDEYVAIGAARQAAWVLSGETEPP 480 >3LL3-A nrPDB Length = 504 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 76/333 (22%), Positives = 128/333 (38%), Gaps = 36/333 (10%) Query: 212 DYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKLSPPVPSCSVVGAISSYYVQRYGFPPG 271 D + +G +L ++ W Q L +E+L V+ I + YV++ G Sbjct: 172 DTTMAAGTGILNLKTLTWDQELLDILKIK-KEQLPKIAQPTKVIFPIKTEYVKKLGIDSD 230 Query: 272 CKVVAFTGDNPASLAGMRLEEGD-IAVSLGTSDTLFLWLQEPMPALEGHIFCNPVDSQHY 330 K++ D S G+ + D A+++GTS + + +P FC P D HY Sbjct: 231 TKIILGASDGYLSTIGVNAIDSDHCALNVGTSGAIRTIVDQPKIDPSASYFCYPADKTHY 290 Query: 331 MALLCFKNGSLMREKIRNE--SVSRSWSDFSKALQSTEMGNGGNLGFYFDVMEITPEIIG 388 + NG ++ R + DF Q+ G+ NL F P + G Sbjct: 291 LLGGPVNNGGIVFNWARQTLFDADETPQDFLDVAQTAPAGSR-NLIFL-------PYLGG 342 Query: 389 RHRFNTENHKVAAFPGDVEV-------RALIEGQFMAKRIHAEGLGYRVMSKTKILATGG 441 + + +F G + RA+IEG A L I ATGG Sbjct: 343 ERAPIWDANARGSFVGLTRMHQKPEMARAVIEGIIFNLYDAASNLIKNTKKPVAINATGG 402 Query: 442 ASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHGLAGGTDVPFSEVVKLA----- 496 + + Q+ A++F+ P+ + S + + + A L G + SE+ + A Sbjct: 403 FLKSDFVRQLCANIFNVPIVTMKEQQSGTLAAMFLARQAL--GLNQDLSEIGQFAQADKV 460 Query: 497 --PNPRLAATPSPGASQVYEALLPQYAKLEQRI 527 PNP+ AAT Y+ L P Y ++ + Sbjct: 461 YFPNPKEAAT--------YQKLFPLYCEIRNAL 485 >2ITM-A nrPDB Length = 484 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 58/231 (25%), Positives = 88/231 (38%), Gaps = 45/231 (19%) Query: 11 LGWDFSTQQVKVVAVD--AELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMW 68 +G D T VKV+ ++ E+ E + R P + Q W Sbjct: 3 IGIDLGTSGVKVILLNEQGEVVAAQTEKLTVSRPHPLWSEQDPEQ--------------W 48 Query: 69 VQALDIILEKMKASGFDFS--QVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQ 126 QA D MKA G S V AL AGQ HG+ AQQ + L P + Sbjct: 49 WQATD---RAMKALGDQHSLQDVKALGIAGQMHGATL--LDAQQRV--LRPAI------- 94 Query: 127 DCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEA 186 +W D +C LEA V ++ +TG+ FT ++ + + PE Sbjct: 95 ---------LWNDGRCAQECTLLEARVPQSR---VITGNLMMPGFTAPKLLWVQRHEPEI 142 Query: 187 YSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGAC 237 + +++ L + G ++ D SD +G L + + WS L AC Sbjct: 143 FRQIDKVLLPKDYLRLRMTGEFAS-DMSDAAGTMWLDVAKRDWSDVMLQAC 192 >5YA1-A nrPDB Length = 540 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 73/354 (20%), Positives = 133/354 (37%), Gaps = 38/354 (10%) Query: 185 EAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEK 244 + Y I+++S + A + G + +D S+ LL + + W A L + Sbjct: 170 DIYRQASTITMISDWLAYMLSGELA-VDPSNAGTTGLLDLTTRDWKPALLDMAGLR-ADI 227 Query: 245 LSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGM-RLEEGDIAVSLGTSD 303 LSP + +++G +SS + G G VV GD G+ + AV GT Sbjct: 228 LSPVKETGTLLGVVSSQAAELCGLKAGTPVVVGGGDVQLGCLGLGVVRPAQTAVLGGTFW 287 Query: 304 TLFLWLQEPMPALEGHIFCNP--------VDSQHY---MALLCFKNGSLMREKIRNESVS 352 + L P+ E ++ NP +S + + + F++ EK+ E + Sbjct: 288 QQVVNLAAPVTDPEMNVRVNPHVIPGMVQAESISFFTGLTMRWFRDAFCAEEKLIAERLG 347 Query: 353 -RSWSDFSKALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAF------PGD 405 +++ + G+ G + + D R RF T H +F P Sbjct: 348 IDTYTLLEEMASRVPPGSWGVMPIFSD----------RMRFKTWYHAAPSFINLSIDPDK 397 Query: 406 VE----VRALIEGQFMAKRIHAEGLG-YRVMSKTKILATGGASHNREILQVLADVFDAPV 460 RAL E + + + + + + + ++ GG S + Q+LADV PV Sbjct: 398 CNKATLFRALEENAAIVSACNLQQIADFSNIHPSSLVFAGGGSKGKLWSQILADVSGLPV 457 Query: 461 YVIDTANSACVGSAYRAFHGLAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYE 514 + + +G A A G+ G +E + TP P ++Y+ Sbjct: 458 NIPVVKEATALGCAIAA--GVGAGIFSSMAETGERLVRWERTHTPDPEKHELYQ 509 >2DPN-A nrPDB Length = 495 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 98/458 (21%), Positives = 155/458 (33%), Gaps = 83/458 (18%) Query: 56 KDGLTVTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSL 115 K G P+ +W L E ++ +G + +VLAL Q+ ++ W Sbjct: 39 KPGWVEHDPLEIWETTLWAAREVLRRAGAEAGEVLALGITNQRETTLLW----------- 87 Query: 116 SPDLRLHQQLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQ 175 D + + L + VW D TT C L A G TG F+G + Sbjct: 88 --DRKTGKPLHNAI------VWQDRRTTPLCEALRAK-GLEPLFRERTGLLFDPYFSGTK 138 Query: 176 IAKIYQQNPEAYSHTERISLVSSFAASLFL-----GSYSPIDYSDGSGMNLLQIQDKVWS 230 + + + P + E + + + G D ++ S L + W Sbjct: 139 LVWLLENVPGLKARAEGGGVAFGTVDTWLIWNLTGGKVHATDPTNASRTLLFNLHTLAWD 198 Query: 231 QACL-----------------GACAPHLEEKLSPPVPSCSVVG-AISSYYVQ-------- 264 L G L E L PVP V+G ++ + Q Sbjct: 199 PELLEALGIPAALLPEVRPSDGDFGETLPELLGAPVPIRGVLGDQQAALFGQAALGGGEG 258 Query: 265 RYGFPPGCKVVAFTGDNPA-SLAGMRLEEGDIAVSLGTSDTLFLWLQEPMPALEGHIFCN 323 + + G ++ TG P S G+ +A SLG T ALEG +F Sbjct: 259 KCTYGTGAFLLLNTGKRPVLSEKGLL---ATVAWSLGGRATY---------ALEGSLFVA 306 Query: 324 PVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSKALQSTEMGNGGNLGFYFDVMEIT 383 A+ K L+RE E+++ S D G Y+D Sbjct: 307 GA------AVGWLKEVGLIRESAEVEALAASVEDTGDVYFVPAFTGLG--APYWDPY-AR 357 Query: 384 PEIIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKRIHAEGLGYRVMSKTKIL-ATGGA 442 ++G R + H RA +EG R + + K+L A GG Sbjct: 358 GTLLGLTRGTSRAHLA---------RAALEGVAFQVRDVVLAMEEEAGVRLKVLKADGGM 408 Query: 443 SHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHG 480 + NR L++ AD+ PV V + + +G+A A G Sbjct: 409 AQNRLFLKIQADLLGVPVAVPEVTETTALGAALMAGVG 446 >3IFR-A nrPDB Length = 508 Score = 35.4 bits (80), Expect = 0.055, Method: Compositional matrix adjust. Identities = 64/302 (21%), Positives = 112/302 (37%), Gaps = 35/302 (11%) Query: 240 HLEEKLSPPV-PSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPAS-LAGMRLEEGDIAV 297 H+ PP P+ V+GA+++ G P G V D+ AS LA GD+ + Sbjct: 204 HIPPSAVPPAHPTHRVLGAVTAEAAALTGLPTGLPVYGGAADHIASALAAGITRPGDVLL 263 Query: 298 SLGTSDTLFLW----LQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMR---EKIRNES 350 G + + + +P L+ H+ MA GS + + + E+ Sbjct: 264 KFGGAGDIIVASATAKSDPRLYLDYHLVPGLYAPNGCMA----ATGSALNWLAKLLAPEA 319 Query: 351 VSRSWSDFSKALQSTEMGNGGNLGFYFDVMEITP--------EIIGRHRFNTENHKVAAF 402 + + G G + + + E TP G +T H Sbjct: 320 GEAAHAQLDALAAEVPAGADGLVCLPYFLGEKTPIHDPFASGTFTGLSLSHTRGHLW--- 376 Query: 403 PGDVEVRALIEGQFMAKRIHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYV 462 RAL+E +A R H L + + A+ G + +R + ++ADV PV + Sbjct: 377 ------RALLEAVALAFRHHVAVLDDIGHAPQRFFASDGGTRSRVWMGIMADVLQRPVQL 430 Query: 463 IDTANSACVGSAY-RAFHGLAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEALLPQYA 521 + + VG+A+ A G + +V+ TP P ++VY+ L ++ Sbjct: 431 LANPLGSAVGAAWVAAIGGGDDLGWDDVTALVRTGEK----ITPDPAKAEVYDRLYRDFS 486 Query: 522 KL 523 L Sbjct: 487 AL 488 >5AZI-A nrPDB Length = 518 Score = 33.5 bits (75), Expect = 0.21, Method: Compositional matrix adjust. Identities = 49/256 (19%), Positives = 96/256 (37%), Gaps = 47/256 (18%) Query: 70 QALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQDCF 129 + + + + K++ F ++ A+ Q+ ++ W ++ L C+ Sbjct: 62 KCMSVAIAKLRQKDASFRKIEAIGITNQRETTVAWDRVTKEPL---------------CY 106 Query: 130 SISDCPVWMDSSTTAQCRQLEAAVGGAQAL--SCLTGSRAYERFTGNQIAKIYQQNPEAY 187 + PVW D T +++ A +GG ++ S +TG F ++ + + P Sbjct: 107 A----PVWNDLRTYDITKKVTAELGGGDSMFASKITGLPVSTYFAAFKMRWMLENVPAVA 162 Query: 188 SHTERISLVSSFAASLFL-----GSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLE 242 R +L + + G D ++ S L+ ++ + WS P L Sbjct: 163 DACRRGTLCFGTIDTWLMYKLSGGKAFVTDVTNASRTFLMDLRTRKWS--------PELC 214 Query: 243 EKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAF----------TGDNPASLAG-MRLE 291 EKL P+ + + + S + Y C V A GD ++L G M E Sbjct: 215 EKLKIPMETLPEIRSNSELF--GYVETDECGVAAALNERTPIMGSIGDQQSALFGNMCFE 272 Query: 292 EGDIAVSLGTSDTLFL 307 +G+ + GT L + Sbjct: 273 KGEAKNTYGTGCFLLM 288 >5W7B-C nrPDB Length = 422 Score = 31.6 bits (70), Expect = 0.90, Method: Compositional matrix adjust. Identities = 20/81 (24%), Positives = 32/81 (39%), Gaps = 4/81 (4%) Query: 96 GQQHGSIYWKA--GAQQALTSLSPDLRLHQ--QLQDCFSISDCPVWMDSSTTAQCRQLEA 151 G HG+ W L L+ D+ Q C +S CP WM ++ T + E Sbjct: 264 GLAHGAFLWDTLHSRYHPLGQLNKDVTYTQLYSFLGCLQVSPCPGWMSANETLRALTSER 323 Query: 152 AVGGAQALSCLTGSRAYERFT 172 A ++ L + S+ + F Sbjct: 324 AQQLSETLRKIAASKKFTNFN 344 >3FLC-O nrPDB Length = 518 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 77/340 (22%), Positives = 120/340 (35%), Gaps = 78/340 (22%) Query: 206 GSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKLSPPVPSCS-VVGAISSYYVQ 264 G DYS+ S L I W Q L ++ + P V S S V G SY Sbjct: 189 GQVHVTDYSNASRTMLYNIHKLEWDQEILDLL--NIPSSMLPEVKSNSEVYGHTRSY--- 243 Query: 265 RYGFPPGCKVVAFTGDNPASLAG-MRLEEGDIAVSLGTSDTLFLWLQEPMPALEGHIFCN 323 R+ + + GD A+L G M E+G I + GT + + E P L + Sbjct: 244 RF-YGSEVPIAGMAGDQQAALFGQMAFEKGMIKNTYGTGAFIVMNTGEE-PQLSDNDLLT 301 Query: 324 PV----DSQHYMAL--LCFKNGS---LMREKIRNESVSRSWSDFSKALQSTEMGNGGNLG 374 + + + Y AL F GS +R+ +R Sbjct: 302 TIGYGINGKVYYALEGSIFVAGSAIQWLRDGLR--------------------------- 334 Query: 375 FYFDVMEITP---EIIGRHRFNTENHKVAAFPG------DVEVRALIEGQFMAK------ 419 ++E +P E+ + + + E + V AF G D E R + G Sbjct: 335 ----MIETSPQSEELAAKAKGDNEVYVVPAFTGLGAPYWDSEARGAVFGLTRGTTKEDFV 390 Query: 420 RIHAEGLGYR------VMSKTK------ILATGGASHNREILQVLADVFDAPVYVIDTAN 467 R + + Y+ M K + GGA+ N ++Q AD+ D V Sbjct: 391 RATLQAVAYQSKDVIDTMKKDSGIDIPLLKVDGGAAKNDLLMQFQADILDIDVQRAANLE 450 Query: 468 SACVGSAYRAFHGLAGGTDVPFSEVVKLAPNPRLAATPSP 507 + +G+AY A GLA G E+ +A ++ P Sbjct: 451 TTALGAAYLA--GLAVGFWKDLDELKSMAEEGQMFTPEMP 488 >3FII-A nrPDB Length = 427 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 20/79 (25%), Positives = 28/79 (35%), Gaps = 19/79 (24%) Query: 477 AFHGLAGGTDVPFSEVVKLAPNPRLAA-------------------TPSPGASQVYEALL 517 A HGL G V + E +K+ P + A S ++Y LL Sbjct: 232 ALHGLYGARGVTYKETIKVKQAPLMIAEKPIRLEEFLTFGGQDLNIITSAMKEKIYNNLL 291 Query: 518 PQYAKLEQRILSQTRGPPE 536 Y K+ R+ PPE Sbjct: 292 ANYEKIATRLSRVNSAPPE 310 >2C5S-A nrPDB Length = 413 Score = 29.6 bits (65), Expect = 3.7, Method: Compositional matrix adjust. Identities = 25/71 (35%), Positives = 32/71 (45%), Gaps = 4/71 (5%) Query: 375 FYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEVRALIEGQFM----AKRIHAEGLGYRV 430 F ME+ PEI G NTE+ V DV VR I + +R+ A GL V Sbjct: 127 FPMRTMELLPEIGGHILENTEDITVDVHNPDVNVRVEIRSGYSYIMCDERMGAGGLPVGV 186 Query: 431 MSKTKILATGG 441 K +L +GG Sbjct: 187 GGKVMVLLSGG 197 >2A8A-A nrPDB Length = 439 Score = 28.5 bits (62), Expect = 6.8, Method: Compositional matrix adjust. Identities = 19/79 (24%), Positives = 28/79 (35%), Gaps = 19/79 (24%) Query: 477 AFHGLAGGTDVPFSEVVKLAPNPRLAA-------------------TPSPGASQVYEALL 517 A HGL G V + E +++ P + A S ++Y LL Sbjct: 232 ALHGLYGARGVTYEETIEVKQAPLMIAEKPIRLEEFLTFGGQDLNIITSAMKEKIYNNLL 291 Query: 518 PQYAKLEQRILSQTRGPPE 536 Y K+ R+ PPE Sbjct: 292 ANYEKIATRLSEVNSAPPE 310 >3HZ4-A nrPDB Length = 140 Score = 28.5 bits (62), Expect = 6.9, Method: Composition-based stats. Identities = 13/51 (25%), Positives = 23/51 (45%) Query: 217 SGMNLLQIQDKVWSQACLGACAPHLEEKLSPPVPSCSVVGAISSYYVQRYG 267 +G ++++ +D WSQ + P + SP P C + Y + YG Sbjct: 4 NGSSIIEFEDMTWSQQVEDSKKPVVVMFYSPACPYCKAMEPYFEEYAKEYG 54 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4BC2-A nrPDB 763 0.0 5VM1-A nrPDB 487 e-138 3I8B-A nrPDB 417 e-117 3LL3-A nrPDB 372 e-103 5YA1-A nrPDB 366 e-101 2ITM-A nrPDB 339 2e-93 Sequences not found previously or not previously below threshold: 3IFR-A nrPDB 174 1e-43 2ZF5-O nrPDB 156 2e-38 2DPN-A nrPDB 151 8e-37 3HZ6-A nrPDB 149 2e-36 1GLD-G nrPDB 147 1e-35 3G25-A nrPDB 143 2e-34 3FLC-O nrPDB 138 5e-33 4E1J-A nrPDB 138 5e-33 2W40-A nrPDB 133 2e-31 2D4W-A nrPDB 128 6e-30 3L0Q-A nrPDB 103 3e-22 3QDK-A nrPDB 101 6e-22 4C23-A nrPDB 90 3e-18 5HUX-A nrPDB 89 4e-18 5HTX-A nrPDB 83 4e-16 2UYT-A nrPDB 75 5e-14 4YZ2-A nrPDB 34 0.22 4EIQ-A nrPDB 33 0.25 3HZ4-A nrPDB 33 0.47 6DXU-D nrPDB 31 0.98 1FOB-A nrPDB 31 1.0 5L9W-A nrPDB 31 1.0 5W7B-C nrPDB 31 1.2 5U29-A nrPDB 31 1.3 >4BC2-A nrPDB Length = 538 Score = 763 bits (1970), Expect = 0.0, Method: Composition-based stats. Identities = 536/536 (100%), Positives = 536/536 (100%) Query: 1 MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLT 60 MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLT Sbjct: 3 MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLT 62 Query: 61 VTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLR 120 VTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLR Sbjct: 63 VTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLR 122 Query: 121 LHQQLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIY 180 LHQQLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIY Sbjct: 123 LHQQLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIY 182 Query: 181 QQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPH 240 QQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPH Sbjct: 183 QQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPH 242 Query: 241 LEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLG 300 LEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLG Sbjct: 243 LEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLG 302 Query: 301 TSDTLFLWLQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSK 360 TSDTLFLWLQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSK Sbjct: 303 TSDTLFLWLQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSK 362 Query: 361 ALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKR 420 ALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKR Sbjct: 363 ALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKR 422 Query: 421 IHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHG 480 IHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHG Sbjct: 423 IHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHG 482 Query: 481 LAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEALLPQYAKLEQRILSQTRGPPE 536 LAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEALLPQYAKLEQRILSQTRGPPE Sbjct: 483 LAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEALLPQYAKLEQRILSQTRGPPE 538 >5VM1-A nrPDB Length = 491 Score = 487 bits (1253), Expect = e-138, Method: Composition-based stats. Identities = 118/533 (22%), Positives = 196/533 (36%), Gaps = 61/533 (11%) Query: 1 MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLT 60 MA H LG D T VK + +D N D P G + Sbjct: 1 MAHHHHHHMYLGLDLGTSGVKALLIDEAQNPVGAAHGELDVSRPH-----------PGWS 49 Query: 61 VTSPVLMWVQALDIILEKMKASG-FDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDL 119 P W++A +E ++A+ +FS + + +GQ HG+ T L + Sbjct: 50 EQDPA-QWIKACRTAIEALRAAHPKEFSAITGIGLSGQMHGA-----------TLLDAED 97 Query: 120 RLHQQLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKI 179 R+ + C +W D+ + + +L+A A +TG+ + FT ++ + Sbjct: 98 RV---------LRPCILWNDTRSYREAAELDAD----PAFRAITGNIVFPGFTAPKLVWV 144 Query: 180 YQQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAP 239 + + ++ ++ L + G Y D SD +G + L + WS L Sbjct: 145 ARNEADIFARIRKVLLPKDYLRLWLTGEYIS-DMSDSAGTSWLDTGARRWSAELLAKTGL 203 Query: 240 HLEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMR-LEEGDIAVS 298 E ++ V G + + + V GDN AS GM ++ G VS Sbjct: 204 G-EGQMPQLVEGSEAAGCLRAELAAEWSLTASVIVAGGAGDNAASACGMGTVKPGHAFVS 262 Query: 299 LGTSDTLFL--WLQEPMPALEGHIFCNPV-DSQHYMALLCFKNGSLMREKIRNESVSRSW 355 LGTS LF +P P H FC+ + + H M ++ +L + ++ V + Sbjct: 263 LGTSGVLFAANGAYQPKPESAVHAFCHALPRTWHQMGVILSAASAL---EWYSKIVGATP 319 Query: 356 SDFSKALQSTEMGNGGNLGFYFDVMEITPE--IIGRHRFNTENHKVAAFPGDVEVRALIE 413 + L T G + E TP R F H+ +A++E Sbjct: 320 QSLDRELGETLKAPGSVTFLPYLSGERTPYNDAKIRGSFCGLEHEADR---SALTQAVLE 376 Query: 414 GQFMAKRIHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGS 473 G A R + L T + A GG S + L+ +A + P+ + + + Sbjct: 377 GVAFAIRDNLLALQSAGTEITSLTAVGGGSRSTYWLKAIATALNVPIALPEEGDFGAAFG 436 Query: 474 AYRAFHGLAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEALLPQYAKLEQR 526 A R A G D PF+ + P+ A T P +ALL Y + QR Sbjct: 437 AARLGLIAATGAD-PFT----ICTPPQTARTIEPE-----QALLSAYDEAYQR 479 >3I8B-A nrPDB Length = 515 Score = 417 bits (1072), Expect = e-117, Method: Composition-based stats. Identities = 136/565 (24%), Positives = 194/565 (34%), Gaps = 109/565 (19%) Query: 7 RRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVL 66 R G D STQ KV DAE E V F G H +G +V Sbjct: 4 RTLVAGVDTSTQSCKVRVTDAETG----ELVRF-----------GQAKHPNGTSVDPS-- 46 Query: 67 MWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQ 126 W A E+ A G D V AL+ GQQHG + L Q Sbjct: 47 YWWSAFQEAAEQ--AGGLD--DVSALAVGGQQHGMVI-----------------LDNQGN 85 Query: 127 DCFSISDCPVWMDSSTTAQCRQLEAAVG---------------GAQALSCLTGSRAYERF 171 I D +W D+S+ Q L +G G Q GS + Sbjct: 86 ---VIRDAMLWNDTSSAPQAAALIEKLGAAPAQDGEPEDPIARGKQRWVKAVGSSPVASY 142 Query: 172 TGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPI-------------DYSDGSG 218 T ++A + + PE I L + S + Y P+ D SD SG Sbjct: 143 TLTKVAWVAENEPENVKKIAAICLPHDWL-SWRIAGYGPVAEGEDAHLEALFTDRSDASG 201 Query: 219 MNLLQIQDKVWS--------QACLGACAP--HLEEKLSPPVPSCSVVGAISSY-YVQRYG 267 + +A GA A H E + P V + + + Sbjct: 202 TIYYDAASNEYRRDLIAMVLEAAEGAKAAQSHAEAIVLPTVLGPRDAAPVKADPAIAGKN 261 Query: 268 FPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQEPMPALEGHIFCNPVDS 327 GC + GDN + G+ + GD+++SLGTS + P L G + + Sbjct: 262 VEGGCLLAPGGGDNAMASLGLGMAVGDVSISLGTSGVAAAISENPTYDLTGAVSGFADCT 321 Query: 328 QHYMALLCFKNGSLMREKIRNESVSRSWSDFSK-ALQSTEMGNGGNLGFYFDVMEITPE- 385 HY+ L C NGS + + R + + + +K A S NG L YFD E TP Sbjct: 322 GHYLPLACTINGSRILDAGRAA-LGVDYDELAKLAFASKPGANGITLVPYFD-GERTPNR 379 Query: 386 ------IIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKRIHAEGLGYRVMSKTKILAT 439 G NT +A RA +EG ++R E + S T+IL Sbjct: 380 PNATATFSGMTLANTTRENLA--------RAFVEGLLCSQRDCLELIRSLGASITRILLI 431 Query: 440 GGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHGLAGGTDVPFSEVVKLAPNP 499 GG + + I + + V T +G+A +A L+G T+ P Sbjct: 432 GGGAKSEAIRTLAPSILGMDVTRPATDEYVAIGAARQAAWVLSGETEPP---------AW 482 Query: 500 RLAATPSPGASQVYEALLPQYAKLE 524 +L + EA+ YAK Sbjct: 483 QLT-IDGVETGEPTEAVYEAYAKAR 506 >3LL3-A nrPDB Length = 504 Score = 372 bits (953), Expect = e-103, Method: Composition-based stats. Identities = 105/535 (19%), Positives = 184/535 (34%), Gaps = 72/535 (13%) Query: 10 CLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMWV 69 +G D T K V D + + + P T+ G L Sbjct: 6 IIGMDVGTTATKGVLYD----INGKAVASVSKGYPLIQTKVGQAEEDPKLIFD------- 54 Query: 70 QALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQDCF 129 A+ I+ + ++ A+S + Q H I D Sbjct: 55 -AVQEIIFDLTQKID--GKIAAISWSSQMHSLI--------------------GLGSDDE 91 Query: 130 SISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSH 189 +++ W D + Q G AQ + TG + ++ + + E +S Sbjct: 92 LLTNSITWAD-NCAKSIVQDAKNRGFAQQIYRKTGMPMHPMAPIYKLLWLKNKKTEVFSQ 150 Query: 190 TERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKLSPPV 249 ++ + + G D + +G +L ++ W Q L +E+L Sbjct: 151 AQKWIGIKEYIIFRLTGKLVT-DTTMAAGTGILNLKTLTWDQELLDILKIK-KEQLPKIA 208 Query: 250 PSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGD-IAVSLGTSDTLFLW 308 V+ I + YV++ G K++ D S G+ + D A+++GTS + Sbjct: 209 QPTKVIFPIKTEYVKKLGIDSDTKIILGASDGYLSTIGVNAIDSDHCALNVGTSGAIRTI 268 Query: 309 LQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNE--SVSRSWSDFSKALQSTE 366 + +P FC P D HY+ NG ++ R + DF Q+ Sbjct: 269 VDQPKIDPSASYFCYPADKTHYLLGGPVNNGGIVFNWARQTLFDADETPQDFLDVAQTAP 328 Query: 367 MGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEV-------RALIEGQFMAK 419 G+ NL F P + G + + +F G + RA+IEG Sbjct: 329 AGSR-NLIFL-------PYLGGERAPIWDANARGSFVGLTRMHQKPEMARAVIEGIIFNL 380 Query: 420 RIHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFH 479 A L I ATGG + + Q+ A++F+ P+ + S + + + A Sbjct: 381 YDAASNLIKNTKKPVAINATGGFLKSDFVRQLCANIFNVPIVTMKEQQSGTLAAMFLARQ 440 Query: 480 GLAGGTDVPFSEVVKLA-------PNPRLAATPSPGASQVYEALLPQYAKLEQRI 527 L G + SE+ + A PNP+ AAT Y+ L P Y ++ + Sbjct: 441 AL--GLNQDLSEIGQFAQADKVYFPNPKEAAT--------YQKLFPLYCEIRNAL 485 >5YA1-A nrPDB Length = 540 Score = 366 bits (939), Expect = e-101, Method: Composition-based stats. Identities = 97/542 (17%), Positives = 186/542 (34%), Gaps = 73/542 (13%) Query: 11 LGWDFSTQQVKVVAVDAELN---VFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLM 67 + D T ++ V D E N V E H G Sbjct: 25 MALDAGTGSIRAVIFDLEGNQIAVGQAEWRHLAVP------------DVPGSMEFDLNKN 72 Query: 68 WVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQD 127 W A + + + + +G + A+S + G + + + D R +++ + Sbjct: 73 WQLACECMRQALHNAGIAPEYIAAVSACSMREGIVLYNNEGAPIWACANVDARAAREVSE 132 Query: 128 CFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAY 187 + + ++ A G ALS + ++ + + Y Sbjct: 133 LKELHNNTFEN---------EVYRATGQTLALSAI-----------PRLLWLAHHRSDIY 172 Query: 188 SHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKLSP 247 I+++S + A + G + +D S+ LL + + W A L + LSP Sbjct: 173 RQASTITMISDWLAYMLSGELA-VDPSNAGTTGLLDLTTRDWKPALLDMAGLRA-DILSP 230 Query: 248 PVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRL-EEGDIAVSLGTSDTLF 306 + +++G +SS + G G VV GD G+ + AV GT Sbjct: 231 VKETGTLLGVVSSQAAELCGLKAGTPVVVGGGDVQLGCLGLGVVRPAQTAVLGGTFWQQV 290 Query: 307 LWLQEPMPALEGHIFCNP--------VDSQHY---MALLCFKNGSLMREKIRNESVS-RS 354 + L P+ E ++ NP +S + + + F++ EK+ E + + Sbjct: 291 VNLAAPVTDPEMNVRVNPHVIPGMVQAESISFFTGLTMRWFRDAFCAEEKLIAERLGIDT 350 Query: 355 WSDFSKALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAF------PGDVE- 407 ++ + G+ G + + D R RF T H +F P Sbjct: 351 YTLLEEMASRVPPGSWGVMPIFSD----------RMRFKTWYHAAPSFINLSIDPDKCNK 400 Query: 408 ---VRALIEGQFMAKRIHAEGLG-YRVMSKTKILATGGASHNREILQVLADVFDAPVYVI 463 RAL E + + + + + + + ++ GG S + Q+LADV PV + Sbjct: 401 ATLFRALEENAAIVSACNLQQIADFSNIHPSSLVFAGGGSKGKLWSQILADVSGLPVNIP 460 Query: 464 DTANSACVGSAYRAFHGLAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEALLPQYAKL 523 + +G A A G+ G +E + TP P ++Y+ ++ + Sbjct: 461 VVKEATALGCAIAA--GVGAGIFSSMAETGERLVRWERTHTPDPEKHELYQDSRDKWQAV 518 Query: 524 EQ 525 Q Sbjct: 519 YQ 520 >2ITM-A nrPDB Length = 484 Score = 339 bits (869), Expect = 2e-93, Method: Composition-based stats. Identities = 110/530 (20%), Positives = 188/530 (35%), Gaps = 64/530 (12%) Query: 11 LGWDFSTQQVKVVAVD--AELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMW 68 +G D T VKV+ ++ E+ E + R P + Q W Sbjct: 3 IGIDLGTSGVKVILLNEQGEVVAAQTEKLTVSRPHPLWSEQDPEQ--------------W 48 Query: 69 VQALDIILEKMKASGFDFS--QVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQ 126 QA D MKA G S V AL AGQ HG+ AQQ + Sbjct: 49 WQATD---RAMKALGDQHSLQDVKALGIAGQMHGATL--LDAQQRV-------------- 89 Query: 127 DCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEA 186 + +W D +C LEA V ++ +TG+ FT ++ + + PE Sbjct: 90 ----LRPAILWNDGRCAQECTLLEARVPQSR---VITGNLMMPGFTAPKLLWVQRHEPEI 142 Query: 187 YSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKLS 246 + +++ L + G ++ D SD +G L + + WS L AC +++ Sbjct: 143 FRQIDKVLLPKDYLRLRMTGEFAS-DMSDAAGTMWLDVAKRDWSDVMLQACDL-SRDQMP 200 Query: 247 PPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEG-DIAVSLGTSDTL 305 + GA+ + +G VVA GDN A G+ + + +SLGTS Sbjct: 201 ALYEGSEITGALLPEVAKAWGM-ATVPVVAGGGDNAAGAVGVGMVDANQAMLSLGTSGVY 259 Query: 306 FLWLQE--PMPALEGHIFCNPV-DSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSKAL 362 F + P H FC+ + H M+++ S + + +S + + A Sbjct: 260 FAVSEGFLSKPESAVHSFCHALPQRWHLMSVMLSA-ASCLDWAAKLTGLSNVPALIA-AA 317 Query: 363 QSTEMGNGGNLGFYFDVMEITP--EIIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKR 420 Q + + E TP + F H+ + RA++EG A Sbjct: 318 QQADESAEPVWFLPYLSGERTPHNNPQAKGVFFGLTHQHG---PNELARAVLEGVGYALA 374 Query: 421 IHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHG 480 + + + + GG + + Q+LAD+ + + A R Sbjct: 375 DGMDVVHACGIKPQSVTLIGGGARSEYWRQMLADISGQQLDYRTGGDVGPALGAARLAQI 434 Query: 481 LAGGTDVPFSEVVKLAP--NPRLAATPSPGASQVYEALLPQYAKLEQRIL 528 A P +++L P + P Y+ + +L Q++L Sbjct: 435 AAN----PEKSLIELLPQLPLEQSHLPDAQRYAAYQPRRETFRRLYQQLL 480 >3IFR-A nrPDB Length = 508 Score = 174 bits (440), Expect = 1e-43, Method: Composition-based stats. Identities = 85/532 (15%), Positives = 158/532 (29%), Gaps = 52/532 (9%) Query: 5 APRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSP 64 A R +G D T + V V S P G P Sbjct: 4 AQGRQVIGLDIGTTSTIAILVRLPDTVVAVASRPTTLSSPH-----------PGWAEEDP 52 Query: 65 VLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQ 124 W +L ++K + G W+ G L + L + Sbjct: 53 A-QWWDNARAVLAELKTTA----------------GESDWRPGGICVTGMLPAVVLLDDR 95 Query: 125 LQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNP 184 + D + +L A V ++A TG+ ++ ++ I + P Sbjct: 96 G---AVLRPSIQQSDGRCGDEVAELRAEV-DSEAFLARTGNGVTQQLVTAKLRWIERHEP 151 Query: 185 EAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEK 244 + + + L G +D + + + + Sbjct: 152 AVFGAIATVCGSYDYINMLLTGERV-VDRNWALEGGFIDLASGTVEADLVALAHIPPSA- 209 Query: 245 LSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRL-EEGDIAVSLGTSD 303 + P P+ V+GA+++ G P G V D+ AS + GD+ + G + Sbjct: 210 VPPAHPTHRVLGAVTAEAAALTGLPTGLPVYGGAADHIASALAAGITRPGDVLLKFGGAG 269 Query: 304 TLFLWLQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRN----ESVSRSWSDFS 359 + + + Y C + E+ + + Sbjct: 270 DIIVASATAKSDPRL-YLDYHLVPGLYAPNGCMAATGSALNWLAKLLAPEAGEAAHAQLD 328 Query: 360 KALQSTEMGNGGNLGFYFDVMEITP----EIIGRHRFNTENHKVAAFPGDVEVRALIEGQ 415 G G + + + E TP G + +H RAL+E Sbjct: 329 ALAAEVPAGADGLVCLPYFLGEKTPIHDPFASGTFTGLSLSHTRGH-----LWRALLEAV 383 Query: 416 FMAKRIHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAY 475 +A R H L + + A+ G + +R + ++ADV PV ++ + VG+A+ Sbjct: 384 ALAFRHHVAVLDDIGHAPQRFFASDGGTRSRVWMGIMADVLQRPVQLLANPLGSAVGAAW 443 Query: 476 RAFHGLAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEALLPQYAKLEQRI 527 A G + V TP P ++VY+ L ++ L + Sbjct: 444 VAAIGGGDDLGW---DDVTALVRTGEKITPDPAKAEVYDRLYRDFSALYATL 492 >2ZF5-O nrPDB Length = 497 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 84/538 (15%), Positives = 166/538 (30%), Gaps = 72/538 (13%) Query: 8 RCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLM 67 + L D T + + D E N+ F H + G +P + Sbjct: 3 KFVLSLDEGTTSARAIIFDRESNIHGIGQYEF-----------PQHYPRPGWVEHNPEEI 51 Query: 68 WVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQD 127 W L I + ++++ + +Q+ A+ Q+ ++ W + Sbjct: 52 WDAQLRAIKDAIQSARIEPNQIAAIGVTNQRETTLVWDKDGKP----------------- 94 Query: 128 CFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAY 187 + + VW T +++ G + TG F+ +++ + P Sbjct: 95 ---LYNAIVWQCRRTAEMVEEIKREYGT--MIKEKTGLVPDAYFSASKLKWLLDNVPGLR 149 Query: 188 SHTER----ISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEE 243 E+ V +F G + DYS+ S L I+ W L E Sbjct: 150 EKAEKGEVMFGTVDTFLIYRLTGEHVT-DYSNASRTMLFNIKKLDWDDELLELFDI-PES 207 Query: 244 KLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRL-EEGDIAVSLGTS 302 L S V G V GD A+L G E G + + GT Sbjct: 208 VLPEVRESSEVYGYTKKEL-----LGAEIPVSGDAGDQQAALFGQAAFEAGMVKATYGTG 262 Query: 303 DTLFLWLQEPMPA----LEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDF 358 + + + + L + + + F G+ + + +R+ + Sbjct: 263 SFILVNTDKMVLYSDNLLTTIAWGLNGRVSYALEGSIFVTGAAV-QWLRDGIKIIKHASE 321 Query: 359 SKALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVE-------VRAL 411 ++ L + N G P +G + G RA Sbjct: 322 TEELATKLESNEGVYFV--------PAFVGLGAPYWDQFARGIIIGITRGTGREHLARAT 373 Query: 412 IEGQFMAKRIHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACV 471 +E R + + V ++ GGA+ N ++Q AD+ + V + + Sbjct: 374 LEAIAYLTRDVVDEMEKLV-QIKELRVDGGATANDFLMQFQADILNRKVIRPVVKETTAL 432 Query: 472 GSAYRAFHGLAGGTDVPFSEVVKLAPNPRLAATPSPGASQ-VYEALLPQYAKLEQRIL 528 G+AY A + +++ ++A + P + E L + + +R + Sbjct: 433 GAAYLAGLAVDY-----WADTREIAELWKAERIFEPKMDEKTRERLYKGWKEAVKRAM 485 >2DPN-A nrPDB Length = 495 Score = 151 bits (380), Expect = 8e-37, Method: Composition-based stats. Identities = 100/550 (18%), Positives = 156/550 (28%), Gaps = 101/550 (18%) Query: 11 LGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMWVQ 70 L D T + + E F + P K G P+ +W Sbjct: 5 LALDQGTTSSRAILFTLEGRPVAVAKREFRQLYP-----------KPGWVEHDPLEIWET 53 Query: 71 ALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQDCFS 130 L E ++ +G + +VLAL Q+ ++ W + Sbjct: 54 TLWAAREVLRRAGAEAGEVLALGITNQRETTLLWDRKTGKP------------------- 94 Query: 131 ISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSHT 190 + + VW D TT C L A G TG F+G ++ + + P + Sbjct: 95 LHNAIVWQDRRTTPLCEALRAK-GLEPLFRERTGLLFDPYFSGTKLVWLLENVPGLKARA 153 Query: 191 E----RISLVSSFAASLFLGSYS-PIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKL 245 E V ++ G D ++ S L + W L A L Sbjct: 154 EGGGVAFGTVDTWLIWNLTGGKVHATDPTNASRTLLFNLHTLAWDPELLEALGI-PAALL 212 Query: 246 SPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAG---MRLEEGDIAVSLGTS 302 PS G + GD A+L G + EG G Sbjct: 213 PEVRPSDGDFGETLPEL-----LGAPVPIRGVLGDQQAALFGQAALGGGEGKCTYGTGAF 267 Query: 303 --------------DTLFLWLQE----PMPALEGHIFCNPVDSQHYMALLCFKNGSLMRE 344 L ALEG +F A+ K L+RE Sbjct: 268 LLLNTGKRPVLSEKGLLATVAWSLGGRATYALEGSLFVAGA------AVGWLKEVGLIRE 321 Query: 345 KIRNESVSRSWSDFSKALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPG 404 E+++ S D P G + + G Sbjct: 322 SAEVEALAASVEDTGDVY-------------------FVPAFTGLGAPYWDPYARGTLLG 362 Query: 405 DVE-------VRALIEGQFMAKRIHAEGLGY-RVMSKTKILATGGASHNREILQVLADVF 456 RA +EG R + + + A GG + NR L++ AD+ Sbjct: 363 LTRGTSRAHLARAALEGVAFQVRDVVLAMEEEAGVRLKVLKADGGMAQNRLFLKIQADLL 422 Query: 457 DAPVYVIDTANSACVGSAYRAFHGLAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEAL 516 PV V + + +G+A A G+ G P + R T G EAL Sbjct: 423 GVPVAVPEVTETTALGAALMA--GVGAGALSPEDVAGRFREAERFLPTMPEGRR---EAL 477 Query: 517 LPQYAKLEQR 526 ++ + +R Sbjct: 478 YRRWREAVER 487 >3HZ6-A nrPDB Length = 511 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 84/466 (18%), Positives = 152/466 (32%), Gaps = 53/466 (11%) Query: 10 CLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMWV 69 +D T +VK D + +HF R + G +G W Sbjct: 7 IATFDIGTTEVKAALADRDGG------LHFQRSIALETYGDG-----NGPVEQD-AGDWY 54 Query: 70 QALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQDCF 129 A+ I SG D +V A+ +GQ Q L QD Sbjct: 55 DAVQRIASSWWQSGVDARRVSAIVLSGQM-----------QNFLPLD---------QDHE 94 Query: 130 SISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSH 189 + ++ D + ++ A G S L + ++ P+A+ Sbjct: 95 PLHRAVLYSDKRPLKEAEEINARHGADNLWSALE-NPMTAASILPKLVFWRASFPQAFGR 153 Query: 190 TERISL-VSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKLSPP 248 + L + G ++ D ++ S L + +D W L L + + Sbjct: 154 LRHVVLGAKDYVVLRLTGRHAT-DRTNASTTGLYRPKDDAWHVELLADYGFSL-DLMPRL 211 Query: 249 VPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEG-DIAVSLGTS-DTLF 306 + VG +S+ ++ GF G V+ GD A+ G+ + + D + LGT+ Sbjct: 212 LEPGEQVGGVSALAARQTGFVSGTPVLCGLGDAGAATLGVGVLDDEDAYLHLGTTGWLAR 271 Query: 307 LWLQEPMPA-LEGHIFCNP-VDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSKALQS 364 L +P+ G IF + + + + N + + R D ++ Sbjct: 272 LTQTDPVGDMPVGTIFRLAGIIAGKTLQVAPVLNAGNILQWALTLVGHRPGEDCAEYFHM 331 Query: 365 TEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDV-------EVRALIEGQFM 417 G D + P + A G + A++EG + Sbjct: 332 AAAEVQGVTVP--DGLLFVPYLHAERCPVELPAPRGALLGVTGATTRAQILLAVLEGAAL 389 Query: 418 AKRIHAEGLGYRVMSKTKIL-ATGGASHNREILQVLADVFDAPVYV 462 + R AE L M K +L GG + + L+++AD + + V Sbjct: 390 SLRWCAELL---GMEKVGLLKVVGGGARSEAWLRMIADNLNVSLLV 432 >1GLD-G nrPDB Length = 501 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 92/519 (17%), Positives = 160/519 (30%), Gaps = 72/519 (13%) Query: 7 RRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVL 66 ++ + D T + V +D + N+ F++ P K G P+ Sbjct: 3 KKYIVALDQGTTSSRAVVMDHDANIISVSQREFEQIYP-----------KPGWVEHDPME 51 Query: 67 MWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQ 126 +W ++E + + Q+ A+ Q+ +I W+ + Sbjct: 52 IWATQSSTLVEVLAKADISSDQIAAIGITNQRETTIVWEKETGKP--------------- 96 Query: 127 DCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEA 186 I + VW T C L+ G + TG F+G ++ I + Sbjct: 97 ----IYNAIVWQCRRTAEICEHLKRD-GLEDYIRSNTGLVIDPYFSGTKVKWILDHVEGS 151 Query: 187 YSHTERISLVSSFAASLFL-----GSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHL 241 R L+ + + G DY++ S L I W L Sbjct: 152 RERARRGELLFGTVDTWLIWKMTQGRVHVTDYTNASRTMLFNIHTLDWDDKMLEVLDI-P 210 Query: 242 EEKLSPPVPSCSVVGAISSYYVQRYGFPPGC--KVVAFTGDNPASLAG-MRLEEGDIAVS 298 E L S V G + G G + GD A+L G + ++EG + Sbjct: 211 REMLPEVRRSSEVYGQTN------IGGKGGTRIPISGIAGDQQAALFGQLCVKEGMAKNT 264 Query: 299 LGTSDTLFLWLQEPMPALE----GHIFCNPVDSQHYMALLCFKNGSLMREKIRNES--VS 352 GT + + E E I C P +Y + +R+E ++ Sbjct: 265 YGTGCFMLMNTGEKAVKSENGLLTTIACGPTGEVNYALEGAVFMAGASIQWLRDEMKLIN 324 Query: 353 RSWSDFSKALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVE----- 407 ++ S+ + G P G + + A G Sbjct: 325 DAYD--SEYFATKVQNTNGVYVV--------PAFTGLGAPYWDPYARGAIFGLTRGVNAN 374 Query: 408 --VRALIEGQFMAKRIHAEGLGY-RVMSKTKILATGGASHNREILQVLADVFDAPVYVID 464 +RA +E R E + + + GGA N ++Q +D+ V + Sbjct: 375 HIIRATLESIAYQTRDVLEAMQADSGIRLHALRVDGGAVANNFLMQFQSDILGTRVERPE 434 Query: 465 TANSACVGSAYRAFHGLAGGTDVPFSEVVKLAPNPRLAA 503 +G+AY A GLA G E+ + A R Sbjct: 435 VREVTALGAAYLA--GLAVGFWQNLDELQEKAVIEREFR 471 >3G25-A nrPDB Length = 501 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 88/543 (16%), Positives = 160/543 (29%), Gaps = 70/543 (12%) Query: 4 HAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTS 63 +A + L D T + + + + + F + P+ G Sbjct: 2 NAMEKYILSIDQGTTSSRAILFNQKGEIAGVAQREFKQYFPQ-----------SGWVEHD 50 Query: 64 PVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQ 123 +W L ++ E + + Q+ + Q+ ++ W Sbjct: 51 ANEIWTSVLAVMTEVINENDVRADQIAGIGITNQRETTVVWDK----------------- 93 Query: 124 QLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQN 183 I VW T + C +L+ G Q TG F G ++ I Sbjct: 94 --HTGRPIYHAIVWQSRQTQSICSELKQQ-GYEQTFRDKTGLLLDPYFAGTKVKWILDNV 150 Query: 184 PEAYSHTERISL----VSSFAASLFLGSYSPI-DYSDGSGMNLLQIQDKVWSQACLGACA 238 A E L + ++ G + I DYS+ S + I D W L Sbjct: 151 EGAREKAENGDLLFGTIDTWLVWKLSGKAAHITDYSNASRTLMFNIHDLEWDDELLELLT 210 Query: 239 PHLEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMR-LEEGDIAV 297 + L S V G Y+ + GD A+L G E GD+ Sbjct: 211 V-PKNMLPEVKASSEVYGKTIDYHFYG----QEVPIAGVAGDQQAALFGQACFERGDVKN 265 Query: 298 SLGTSDTLFLWLQEPMPALEGHIF---CNPVD-SQHYMALLCFKNGSLMREKIRNESVSR 353 + GT + + + E + +D +Y + +R Sbjct: 266 TYGTGGFMLMNTGDKAVKSESGLLTTIAYGIDGKVNYALEGSIFVSGSAIQWLR------ 319 Query: 354 SWSDFSKALQSTEMG-NGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVE----- 407 D + + S + + + + P +G ++ A G Sbjct: 320 ---DGLRMINSAPQSESYATRVDSTEGVYVVPAFVGLGTPYWDSEARGAIFGLTRGTEKE 376 Query: 408 --VRALIEGQFMAKRIHAEGLGY-RVMSKTKILATGGASHNREILQVLADVFDAPVYVID 464 +RA +E R E + + + GGA N I+Q AD+ + V + Sbjct: 377 HFIRATLESLCYQTRDVMEAMSKDSGIDVQSLRVDGGAVKNNFIMQFQADIVNTSVERPE 436 Query: 465 TANSACVGSAYRAFHGLAGGTDVPFSEVVKLAPNPRLAATPSPGASQVY-EALLPQYAKL 523 + +G+A+ A + +A N +L P + E L + K Sbjct: 437 IQETTALGAAFLAGLAVGFWESKD-----DIAKNWKLEEKFDPKMDEGEREKLYRGWKKA 491 Query: 524 EQR 526 + Sbjct: 492 VEA 494 >3FLC-O nrPDB Length = 518 Score = 138 bits (348), Expect = 5e-33, Method: Composition-based stats. Identities = 87/532 (16%), Positives = 153/532 (28%), Gaps = 70/532 (13%) Query: 5 APRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSP 64 A + + D T + + D F + K G + Sbjct: 14 AEKNYVMAIDQGTTSSRAIIFDRNGKKIGSSQKEF-----------PQYFPKSGWVEHNA 62 Query: 65 VLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQ 124 +W +I SG + + Q+ ++ W Q Sbjct: 63 NEIWNSVQSVIAGAFIESGIRPEAIAGIGITNQRETTVVWDKTTGQP------------- 109 Query: 125 LQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNP 184 I++ VW ++ QL+ G + + TG F+ ++ + Sbjct: 110 ------IANAIVWQSRQSSPIADQLKVD-GHTEMIHEKTGLVIDAYFSATKVRWLLDNIE 162 Query: 185 EAYSHTERISL----VSSFAASLFL-GSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAP 239 A + L + S+ G DYS+ S L I W Q L Sbjct: 163 GAQEKADNGELLFGTIDSWLVWKLTDGQVHVTDYSNASRTMLYNIHKLEWDQEILDLLNI 222 Query: 240 HLEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAG-MRLEEGDIAVS 298 L + V G SY + GD A+L G M E+G I + Sbjct: 223 -PSSMLPEVKSNSEVYGHTRSYRFYG----SEVPIAGMAGDQQAALFGQMAFEKGMIKNT 277 Query: 299 LGTSDTLFLWL-QEPMP---ALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRS 354 GT + + +EP L I +Y + +R+ Sbjct: 278 YGTGAFIVMNTGEEPQLSDNDLLTTIGYGINGKVYYALEGSIFVAGSAIQWLRDGLRMIE 337 Query: 355 WSDFSKALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVE------- 407 S S+ L + G+ P G ++ A G Sbjct: 338 TSPQSEELAAKAKGDNEVYVV--------PAFTGLGAPYWDSEARGAVFGLTRGTTKEDF 389 Query: 408 VRALIEGQFMAKRIHAEGLGY-RVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTA 466 VRA ++ + + + + + GGA+ N ++Q AD+ D V Sbjct: 390 VRATLQAVAYQSKDVIDTMKKDSGIDIPLLKVDGGAAKNDLLMQFQADILDIDVQRAANL 449 Query: 467 NSACVGSAYRAFHGLAGGTDVP----FSEVVKLAPNPRLAATPSPGASQVYE 514 + +G+AY A + D+ +E ++ P+ +YE Sbjct: 450 ETTALGAAYLAGLAVGFWKDLDELKSMAEEGQMFTP----EMPAEERDNLYE 497 >4E1J-A nrPDB Length = 520 Score = 138 bits (347), Expect = 5e-33, Method: Composition-based stats. Identities = 82/529 (15%), Positives = 152/529 (28%), Gaps = 74/529 (13%) Query: 10 CLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMWV 69 L D T + + D + F H K G P +W Sbjct: 28 ILAIDQGTTSTRAIVFDGNQKIAGVGQKEFK-----------QHFPKSGWVEHDPEEIWQ 76 Query: 70 QALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQDCF 129 + + E ++ SG + + A+ Q+ + W + Sbjct: 77 TVVSTVKEAIEKSGITANDIAAIGITNQRETVVVWDRETGKP------------------ 118 Query: 130 SISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSH 189 I + VW D T A C +L+ G + TG F+G ++ + A Sbjct: 119 -IHNAIVWQDRRTAAFCDKLKKK-GLEKTFVKKTGLLLDPYFSGTKLNWLLSNVKGAQVR 176 Query: 190 TERISL----VSSFAASLFL-GSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEK 244 + L + +F G D ++ S L I + W +E Sbjct: 177 AAKGELCFGTIDTFLIWRLTGGECFCTDATNASRTLLYNIAENAWDDELTEVLRV-PKEM 235 Query: 245 LSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMR-LEEGDIAVSLGTSD 303 L + G F ++ GD A+ G + G + + GT Sbjct: 236 LPEVKDCAADFGVTDPSL-----FGAAIPILGVAGDQQAATIGQACFKPGMLKSTYGTGC 290 Query: 304 TLFLWLQEPMPALEGHIFCNPV-----DSQHYMALLCFKNGSLMREKIRNESVSRSWSDF 358 L + M + + ++ + + F G+ + + +R D Sbjct: 291 FALLNTGKDMVRSKNRLLTTIAYRLDGETTYALEGSIFVAGAAV-QWLR---------DG 340 Query: 359 SKALQSTE-MGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVE-------VRA 410 K +++ G+ + + P G + + A G RA Sbjct: 341 LKVIKAAPDTGSLAESADPSQEVYLVPAFTGLGAPHWDPDARGAIFGMTRNTGPAEFARA 400 Query: 411 LIEGQFMAKRIHAEGLGY---RVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTAN 467 +E R E + R + T + GG + +Q L+D+ DAPV Sbjct: 401 ALEAVCYQTRDLLEAMHKDWRRNGNDTVLRVDGGMVASDWTMQRLSDLLDAPVDRPVILE 460 Query: 468 SACVGSAYRAFHGLAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEAL 516 + +G A+ A + A + P + + Sbjct: 461 TTALGVAWLAGSRAGVWPNQE-----AFAKSWARDRRFEPHMDEATRKV 504 >2W40-A nrPDB Length = 503 Score = 133 bits (334), Expect = 2e-31, Method: Composition-based stats. Identities = 83/493 (16%), Positives = 151/493 (30%), Gaps = 65/493 (13%) Query: 9 CCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMW 68 L D STQ KV D ELN+ + +++ + K G P+ + Sbjct: 5 VILSIDQSTQSTKVFFYDEELNIVHSNNLNHE-----------QKCLKPGWYEHDPIEIM 53 Query: 69 VQALDIILEKMKASGFDFSQV--LALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQ 126 +++ E +K ++ V + Q+ I W + L Sbjct: 54 TNLYNLMNEGIKVLKDKYTSVIIKCIGITNQRETVIIWDRITGKPLY------------- 100 Query: 127 DCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEA 186 + VW+D+ + A + TG+ F+ +I + Q NPE Sbjct: 101 ------NAIVWLDTRVEELVTEFSAKYNNND-IQKKTGTYFNTYFSAFKILWLIQNNPEI 153 Query: 187 YSHTE----RISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLE 242 + I ++++ D ++ S L+ I W + Sbjct: 154 KQKIDDGTAVIGNINTWLIFNLTKGNCYTDVTNASRTLLMDINTLQWDEKMCKIFNITNM 213 Query: 243 EKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRL-EEGDIAVSLGT 301 L +CS G + S +V Y + GD ++ G + +EG+ + GT Sbjct: 214 SVLPEIKSNCSNFGLVKSEHVPDY---LNIPITGCIGDQQSACIGQAIFDEGEAKCTYGT 270 Query: 302 SDTLFLWLQEPMPAL------EGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSW 355 L + E + N D Y + + Sbjct: 271 GVFLLINTGEKVVYSTCGLITTICYKFNDNDKPKYALEGSIGTAGSGVSWLLKNKLIDDP 330 Query: 356 SDFSKALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDV-------EV 408 S+ S ++ E G P G + + A+ G V Sbjct: 331 SEASDIMEKCENTTGVIFV---------PAFSGLYAPRWRSDARASIYGMTFNTERSHIV 381 Query: 409 RALIEGQFMAKRIHAEGLGY-RVMSKTKILAT-GGASHNREILQVLADVFDAPVYVIDTA 466 RAL+EG + L + +L GG + N+ +Q +D+ + + V Sbjct: 382 RALLEGIAFQLNEIVDSLTSDMGIEMLHVLRCDGGMTKNKPFMQFNSDIINTKIEVSKYK 441 Query: 467 NSACVGSAYRAFH 479 +G+A A Sbjct: 442 EVTSLGAAVLAGL 454 >2D4W-A nrPDB Length = 504 Score = 128 bits (321), Expect = 6e-30, Method: Composition-based stats. Identities = 80/495 (16%), Positives = 140/495 (28%), Gaps = 67/495 (13%) Query: 10 CLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMWV 69 L D T + + D ++ + D+ P + G +P +W Sbjct: 4 VLAIDQGTTSSRAIVFDHSGEIYSTGQLEHDQIFP-----------RAGWVEHNPEQIWN 52 Query: 70 QALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQDCF 129 +++ + + A+ Q+ ++ W + + Sbjct: 53 NVREVVGLALTRGNLTHEDIAAVGITNQRETAVVWDKTTGKPVY---------------- 96 Query: 130 SISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSH 189 + VW D+ T +L GA+ + G F+G +I I A Sbjct: 97 ---NAIVWQDTRTQKIVDELGGD-EGAEKYKSIVGLPLATYFSGPKIKWILDNVEGAREK 152 Query: 190 TERISLVSSFAASLFL--------GSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHL 241 E+ L+ + L G D ++ S L+ + W + L Sbjct: 153 AEKGDLLFGNTDTWVLWNMTGGTEGGVHVTDVTNASRTMLMDLDTLSWREDIAADMGIPL 212 Query: 242 EEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMR-LEEGDIAVSLG 300 L S V G + + G PG + GD A+ G E G + G Sbjct: 213 -SMLPDIRSSSEVYG-----HGRPRGLVPGVPIAGILGDQQAATFGQACFEVGQAKNTYG 266 Query: 301 TSDTLFLWLQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSK 360 T + L L + + + GS+ + + + F Sbjct: 267 TGNFLLLNTGTEKVMSKNGLLTTVCYKIGDAPAVYALEGSIAVTGSLVQWLRDNLGMFED 326 Query: 361 A-----LQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEV------- 408 A L NGG P G A G Sbjct: 327 APDVEWLAGKVQDNGGAYFV--------PAFSGLFAPYWRPDARGALVGLTRYVNRNHIA 378 Query: 409 RALIEGQFMAKRIHAEGL-GYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTAN 467 RA +E R + + + T++ GG N ++Q AD V A Sbjct: 379 RAALEATAFQSREVVDAMNADSGVDLTELRVDGGMVANELLMQFQADQLGVDVVRPKVAE 438 Query: 468 SACVGSAYRAFHGLA 482 + +G+AY A + Sbjct: 439 TTALGAAYAAGIAVG 453 >3L0Q-A nrPDB Length = 554 Score = 103 bits (255), Expect = 3e-22, Method: Composition-based stats. Identities = 77/551 (13%), Positives = 153/551 (27%), Gaps = 85/551 (15%) Query: 11 LGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMWVQ 70 +G D T + D + + + S P K S +W Sbjct: 8 IGVDVGTGSARAGVFDLQGRMVGQASREITMFKP-----------KADFVEQSSENIWQA 56 Query: 71 ALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQDCFS 130 + + + + + + QV L A +L L + + Sbjct: 57 VCNAVRDAVNQADINPIQVKGLG------------FDATCSLVVLDKEGNPLTVSPSGRN 104 Query: 131 ISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSHT 190 + VWMD Q ++ A + G ++ + Q P +S+ Sbjct: 105 EQNVIVWMDHRAITQAERINAT---KHPVLEFVGGVISPEMQTPKLLWLKQHMPNTWSNV 161 Query: 191 ERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQA---------CLGACAPHL 241 + + F + S L +D+ W + L A + Sbjct: 162 GHLFDLPDFLTWRATKDETRSLCSTVCKWTYLGHEDR-WDPSYFKLVGLADLLDNNAAKI 220 Query: 242 EEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLGT 301 + P + +S G PG V D A G+ G + Sbjct: 221 GATVKPM--GAPLGHGLSQRAASEMGLIPGTAVSVSIIDAHAGTIGILGASGVTGENANF 278 Query: 302 SDTLFLWLQEPMPALEGHIFCNPVDSQHYMALLC--FKNGSLMREKIRNESVSRSWSDFS 359 + L + S H+++ + + + L + S + + Sbjct: 279 DRRIALIGGTSTAHMAMS------RSAHFISGIWGPYYSAILPEYWLNEGGQSATGALID 332 Query: 360 KALQSTE---------------------------MGNGGNLGFYFDVMEITPEIIGRHRF 392 +QS G N+ F + + + P G Sbjct: 333 HIIQSHPCYPALLEQAKNKGETIYEALNYILRQMAGEPENIAFLTNDIHMLPYFHGNRSP 392 Query: 393 NTENH--------KVAAFPGDVEVR--ALIEGQFMAKRIHAEGLGYRVMSKTKILATGGA 442 + K++ P D+ +R A I+ + R E + + ++A+GG Sbjct: 393 RANPNLTGIITGLKLSTTPEDMALRYLATIQALALGTRHIIETMNQNGYNIDTMMASGGG 452 Query: 443 SHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHGLAGGTDVPFSEVVKLAPNPRLA 502 + N +Q A+ + + + + + +GSA +A G E + Sbjct: 453 TKNPIFVQEHANATGCAMLLPEESEAMLLGSAMMG--TVAAGVFESLPEAMAAMSRIGKT 510 Query: 503 ATPSPGASQVY 513 TP + Y Sbjct: 511 VTPQTNKIKAY 521 >3QDK-A nrPDB Length = 572 Score = 101 bits (252), Expect = 6e-22, Method: Composition-based stats. Identities = 87/549 (15%), Positives = 171/549 (31%), Gaps = 54/549 (9%) Query: 11 LGWDFSTQQVKVVAVDAELNVFYEESVH------FDRDLPEFGTQGGVHVHKDGLTVTSP 64 +G D+ T+ + V +D + V D+ LP + G + P Sbjct: 8 IGVDYGTESGRAVLIDLSNGQELADHVTPYRHGVIDQYLPNTNIKLGHE-----WALQHP 62 Query: 65 VLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQ 124 + + MK SG D V+ + + Q H Sbjct: 63 LDYVEVLTTSVPAVMKESGVDADDVIGIGVDFTACTMLPVDEEGQPLCLLAQYKDNPHSW 122 Query: 125 LQDCFSISDCPVWMDSSTTAQCRQL-EAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQN 183 ++ +W + + + E A +A G + + ++ +I + Sbjct: 123 VK---------LWKHHAAQDKANAINEMAEKRGEAFLPRYGGKISSEWMIAKVWQILDEA 173 Query: 184 PEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEE 243 + Y+ T++ + + S G + G + + S A P LE Sbjct: 174 EDVYNRTDQFLEATDWIVSQMTGKIVKNSCTAGYKAIWHKREGYP-SNEFFKALDPRLEH 232 Query: 244 KLSP-----PVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLE-EGDIAV 297 + VP G + ++ G PG V D A++ + + G + + Sbjct: 233 LTTTKLRGDIVPLGERAGGLLPEMAEKMGLNPGIAVAVGNVDAHAAVPAVGVTTPGKLVM 292 Query: 298 SLGTSDTLFLWLQEPMPALEGHIFCNPVDSQ---HYMA-----------LLCFKN---GS 340 ++GTS L ++ E C V+ Y+ F + Sbjct: 293 AMGTSICHMLLGEK---EQEVEGMCGVVEDGIIPGYLGYEAGQSAVGDIFAWFVKHGVSA 349 Query: 341 LMREKIRNESVSRSWSDFSKALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVA 400 ++ + + V+ + + G G L + + + + + Sbjct: 350 ATFDEAQEKGVNV-HALLEEKASQLRPGESGLLALDWWNGNRSILVDTELSGMLLGYTLQ 408 Query: 401 AFPGDVEVRALIEGQFMAKRIHAEGLGYRVMSKTKILATGGA-SHNREILQVLADVFDAP 459 P ++ RAL+E R + R + ++ A GG N ++Q+ ADV + Sbjct: 409 TKPEEI-YRALLEATAFGTRAIVDAFHGRGVEVHELYACGGLPQKNHLLMQIFADVTNRE 467 Query: 460 VYVIDTANSACVGSAYRAFHGLAG--GTDVPFSEVVKLAPNPR-LAATPSPGASQVYEAL 516 + V + + +G+A A G E K + P P +YE L Sbjct: 468 IKVAASKQTPALGAAMFASVAAGSEVGGYDSIEEAAKKMGRVKDETFKPIPEHVAIYEKL 527 Query: 517 LPQYAKLEQ 525 +Y L Sbjct: 528 YQEYVTLHD 536 >4C23-A nrPDB Length = 473 Score = 89.7 bits (220), Expect = 3e-18, Method: Composition-based stats. Identities = 66/320 (20%), Positives = 113/320 (35%), Gaps = 20/320 (6%) Query: 163 TGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLL 222 TG++ E T Q+ K Q++P+++ T +I L+ L G ++ + S S L Sbjct: 128 TGNQIMEINTLFQLFKARQESPDSFYKTNKILLMPDLFNYLLTGKFAT-EKSIASTTQLF 186 Query: 223 QIQDKVWSQACLGACAPHLEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVV-AFTGDN 281 + + W+Q L L V +V+G I Y G VV + D Sbjct: 187 DPRSQNWNQNILKLFEL-DSSLLPEIVSEGNVLGRIKEEY----GL-GDIPVVNVCSHDT 240 Query: 282 PASLAGMRLEEGDIAVSLGTSDTLFLWLQEPMPALEGHIFCNPVDSQHYMALLCFKN--G 339 +++ + EG + +S GT + + L P+ E + + + KN G Sbjct: 241 ASAIVSVPKTEGSLFISSGTWSLVGVELTSPILTTESFSYGFTNEVGKDGVITFLKNCTG 300 Query: 340 SLMREKIRN--ESVSRSWSDFSKALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTEN- 396 + E++R E +++S F E NL H+ TE Sbjct: 301 LWIIEELRRSFERRGKAYS-FDDIRTMVEK-EKENLPLIDTESTEFATESDMHKTLTEYL 358 Query: 397 ---HKVAAFPGDVEVRALIEGQFMAKRIHAEGLGYRVMSK-TKILATGGASHNREILQVL 452 H+ + + + E R E L +I GG + Q++ Sbjct: 359 AYHHETREWTDGQLFKIVYESLAETYRKAIELLEELTHKVYKRIYVIGGGARASYFNQMI 418 Query: 453 ADVFDAPVYVIDTANSACVG 472 AD V T + VG Sbjct: 419 ADRTGKEVLTGLT-EATAVG 437 >5HUX-A nrPDB Length = 436 Score = 89.3 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 79/475 (16%), Positives = 149/475 (31%), Gaps = 64/475 (13%) Query: 11 LGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMWVQ 70 LG DF T + +A D + + SV F + + +W + Sbjct: 7 LGLDFGTSGARAIACDFDSDRSVSVSVTFPKTSQNWPQ------------------VWRE 48 Query: 71 ALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQDCFS 130 AL +L ++ A S++ ++ G G++ Q T Sbjct: 49 ALWQLLTQIPA--DWRSRIERIAIDGTS-GTVLLCDREGQPQTE---------------- 89 Query: 131 ISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSHT 190 P+ + + L V A T S A +QQ A Sbjct: 90 ----PLLYNQACPIDLADLADWVPADHAALSSTSSLAK--------LWFWQQQFGALPPD 137 Query: 191 ERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKLSPPVP 250 +I + + + G DY + + +++ +S+ L + L L Sbjct: 138 WQILAQADWLSLQLHGCSQQSDYHNALKLGYSPDRER-FSKNLLDS---ELGALLPVVHE 193 Query: 251 SCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRL-EEGDIAVSLGTSDTLFLWL 309 +G I Q +G P C++ A T D+ A+ + G+ SLG++ L L Sbjct: 194 PGVAIGPILPAIAQEFGLSPDCQICAGTTDSIAAFLASGAHQPGEAVTSLGSTIVLKLLS 253 Query: 310 QEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSKALQSTEMGN 369 Q + ++ + + +++ G +R S + T+ + Sbjct: 254 QVAVSDRLTGVYSHKL-GGYWLTGGASNCGGAT---LRQFFPDTELESLSCQIDPTKK-S 308 Query: 370 GGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKRIHAEGLGYR 429 G + E P P ++ L+EG + + + L Sbjct: 309 GLDYYPLPSRGERFPIADPDRLPQL--EPRPENPVQ-FLQGLLEGLTQVETLGYQRLQDL 365 Query: 430 VMSK-TKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHGLAG 483 + +I GG + N Q+ P+ + + G+A A GLA Sbjct: 366 GATPLKRIWTAGGGAKNAVWQQLRQQAIGVPIAIAPNTEA-AFGTARLAAFGLAA 419 >5HTX-A nrPDB Length = 439 Score = 82.7 bits (202), Expect = 4e-16, Method: Composition-based stats. Identities = 72/477 (15%), Positives = 150/477 (31%), Gaps = 61/477 (12%) Query: 8 RCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLM 67 + LG DF T + +D + E R+ P F + + G Sbjct: 15 KLYLGMDFGTSGGRFTVIDEQ----GEIKAQGKREYPPFMKEESM-----GW-----ASS 60 Query: 68 WVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQD 127 W L +LE + + S V ++S G + ++ P L Sbjct: 61 WKATLFSLLEDIPVTVR--SLVSSISLDGT--SATTLILNSESGEVLCQPYLYNQSCPDA 116 Query: 128 CFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAY 187 + + + G L L ++ + P Sbjct: 117 LPEVKSIAPANHTVCS-----------GTSTLCKL-------------VSWWNTEVPN-- 150 Query: 188 SHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKLSP 247 + + + + L G DY++ + + + + LG + L Sbjct: 151 RESAVLLHQADWLLWLLHGRLGVSDYNNALKVGY-DPESESYPSWLLGQP---YSQLLPK 206 Query: 248 PVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRL-EEGDIAVSLGTSDTLF 306 + +G + + +++GFP C V T D+ A+ R E G SLG++ + Sbjct: 207 VQAPGTSIGNLKESFTRQFGFPDDCIVCTGTTDSIAAFLAARATEPGKAVTSLGSTLAIK 266 Query: 307 LWLQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSKALQSTE 366 L + + ++ + +D + + G+++R+ +E + R + + + Sbjct: 267 LLSTKRVDDARYGVYSHRLDDKWLVGGASNTGGAILRQLFSDEQLERLSQEINPMV---- 322 Query: 367 MGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEV-RALIEGQFMAKRIHAEG 425 G+ + E P N + DVE ++E + + Sbjct: 323 -GSPLDYYPLQSSGERFPIAD----PNLAPRLLPRPESDVEFLHGILESIARIEGKGYKL 377 Query: 426 LGYRV-MSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHGL 481 L ++L GG + N + +++ V PV + G++ A G Sbjct: 378 LKELGATEAEEVLTAGGGAKNDKWIKIRQRVLGLPVKKAVHTEA-SYGASLLALKGA 433 >2UYT-A nrPDB Length = 489 Score = 75.4 bits (183), Expect = 5e-14, Method: Composition-based stats. Identities = 82/513 (15%), Positives = 154/513 (30%), Gaps = 56/513 (10%) Query: 8 RCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLM 67 R C+ D +V+ ++R+ + +H +GL + + Sbjct: 4 RNCVAVDLGASSGRVML------------ARYERECRSLTLRE-IHRFNNGLHSQNGYVT 50 Query: 68 W-VQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQ 126 W V +L+ + ++V A A G W + L QQ Q Sbjct: 51 WDVDSLESAIR------LGLNKVCAAGIAIDSIGIDTWGVDF----------VLLDQQGQ 94 Query: 127 DCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEA 186 + DS T Q + +G + + +G + T Q+ + +Q PE Sbjct: 95 RVGL---PVAYRDSRTNGLMAQAQQQLG-KRDIYQRSGIQFLPFNTLYQLRALTEQQPEL 150 Query: 187 YSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKLS 246 H L+ + + G +Y++ + L+ I W ++ L + + Sbjct: 151 IPHIAHALLMPDYFSYRLTGKM-NWEYTNATTTQLVNINSDDWDESLLAWSGAN-KAWFG 208 Query: 247 PPVPSCSVVGAISSYYVQRYGFPPGC---KVVAFTGDNPASLAGMRLEEGDIA-VSLGTS 302 P +V+G + P G V + D +++ L A +S GT Sbjct: 209 RPTHPGNVIG--------HWICPQGNEIPVVAVASHDTASAVIASPLNGSRAAYLSSGTW 260 Query: 303 DTLFLWLQEP---MPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFS 359 + Q P AL +I Y L L++ ++ ++ + Sbjct: 261 SLMGFESQTPFTNDTALAANITNEGGAEGRYRVLKNIMGLWLLQRVLQERQINDLPALI- 319 Query: 360 KALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEV-RALIEGQFMA 418 A + D E+ + D E+ R + + + Sbjct: 320 -AATQALPACRFIINPNDDRFINPDEMCSEIQAACREMAQPIPESDAELARCIFDSLALL 378 Query: 419 KRIHAEGLGY-RVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRA 477 L R +++ GG N + Q+ AD V S + Sbjct: 379 YADVLHELAQLRGEDFSQLHIVGGGCQNTLLNQLCADACGIRVIAGPVEASTLGNIGIQL 438 Query: 478 FHGLAGGTDVPFSEVVKLAPNPRLAATPSPGAS 510 F +VV N TP+P + Sbjct: 439 MTLDELNNVDDFRQVVSTTAN-LTTFTPNPDSE 470 >4YZ2-A nrPDB Length = 677 Score = 33.8 bits (75), Expect = 0.22, Method: Composition-based stats. Identities = 15/57 (26%), Positives = 23/57 (40%) Query: 154 GGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSP 210 G + TG +TG + A IY + A + + L SS++A SP Sbjct: 473 PGRGIIESSTGRILIPSYTGKESAFIYSDDNGASWKVKVVPLPSSWSAEAQFVELSP 529 >4EIQ-A nrPDB Length = 549 Score = 33.4 bits (74), Expect = 0.25, Method: Composition-based stats. Identities = 24/101 (23%), Positives = 38/101 (37%), Gaps = 11/101 (10%) Query: 250 PSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIA--VSLGTSDTLFL 307 P S +G S +R+G + + GD+P A + G + LGT+DT Sbjct: 65 PKVSTIGPRSMELFRRWGVAKQIRTAGWPGDHPLDAAWVTRVGGHEVYRIPLGTADTRAT 124 Query: 308 WLQEPMPALEGHIFCNPVDSQHYM-ALLCFKNGSLMREKIR 347 P P + H++ LL G +R + R Sbjct: 125 PEHTPEPD--------AICPAHWLAPLLAEAVGERLRTRSR 157 >3HZ4-A nrPDB Length = 140 Score = 32.6 bits (72), Expect = 0.47, Method: Composition-based stats. Identities = 13/53 (24%), Positives = 22/53 (41%) Query: 218 GMNLLQIQDKVWSQACLGACAPHLEEKLSPPVPSCSVVGAISSYYVQRYGFPP 270 G ++++ +D WSQ + P + SP P C + Y + YG Sbjct: 5 GSSIIEFEDMTWSQQVEDSKKPVVVMFYSPACPYCKAMEPYFEEYAKEYGSSA 57 >6DXU-D nrPDB Length = 830 Score = 31.5 bits (69), Expect = 0.98, Method: Composition-based stats. Identities = 22/154 (14%), Positives = 52/154 (33%), Gaps = 11/154 (7%) Query: 54 VHKDGLTVTSPVLMWVQALDIILEKMKASGFDFSQVLALS-GAGQQHGSIYWKAGAQQAL 112 ++ + L W + +++A G + +S Q++ + W A + Sbjct: 679 KRRNSQDYPAAGLRWNCVYQEGMNEIRAVGVKKKEKKEVSDVIRQEYQTAKWDKEAACQV 738 Query: 113 TSLSPDLRLHQQLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSC----LTGSRAY 168 + LS ++ + +Q+ + G +L C TGSR Sbjct: 739 SLLS------EEGDTALVQVQLIDKNGIRCLSSKKQITFEIAGDGSLICNLGTSTGSRKV 792 Query: 169 ERFTGNQIAKIYQQNPEAYSHTERISLVSSFAAS 202 + + G + +I + + + L ++F Sbjct: 793 QAYNGRALIRIKRNEGNSVVAVKSEGLPTAFLEL 826 >1FOB-A nrPDB Length = 334 Score = 31.5 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 13/100 (13%), Positives = 31/100 (31%) Query: 36 SVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMWVQALDIILEKMKASGFDFSQVLALSGA 95 S++ D L + G + T + Q + LE + + +S Sbjct: 75 SLYLDLHLSDTWADPSDQTTPSGWSTTDLGTLKWQLYNYTLEVCNTFAENDIDIEIISIG 134 Query: 96 GQQHGSIYWKAGAQQALTSLSPDLRLHQQLQDCFSISDCP 135 + + W G + +++ L +++ P Sbjct: 135 NEIRAGLLWPLGETSSYSNIGALLHSGAWGVKDSNLATTP 174 >5L9W-A nrPDB Length = 684 Score = 31.5 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 29/160 (18%), Positives = 42/160 (26%), Gaps = 14/160 (8%) Query: 91 ALSGAGQ-QHGSIYWKAGAQQALTSLSPDLRLHQQLQDCFSISDCPVWMDSSTTAQCRQL 149 AL AGQ Q GS + A T R + D F C +T + + Sbjct: 398 ALVLAGQNQWGSSFADMLAYSINTEGQGA-RPTEDGMDAFGFPWCVFGRAPNTESVENEF 456 Query: 150 EAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSHT----ERISLVSSFAASLFL 205 V + G Y G + PE Y ++ Sbjct: 457 PLLVPLSNHWKDSCGHGKYRGGVGTAQVWVAHHVPELYMMAIADNTKLQTPQP-----LF 511 Query: 206 GSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKL 245 G Y+P G+ + K +E L Sbjct: 512 GGYAPC---TVPGIGIRNANIKELMAEGSDKIKLDVETLL 548 >5W7B-C nrPDB Length = 422 Score = 31.1 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 25/125 (20%), Positives = 46/125 (36%), Gaps = 4/125 (3%) Query: 70 QALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKA--GAQQALTSLSPDLRLHQQLQ- 126 Q +L+ ++A + G HG+ W L L+ D+ Q Sbjct: 238 QLYANVLKMLEALNSHLPTGSHVILYGLAHGAFLWDTLHSRYHPLGQLNKDVTYTQLYSF 297 Query: 127 -DCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPE 185 C +S CP WM ++ T + E A ++ L + S+ + F + +Q+ E Sbjct: 298 LGCLQVSPCPGWMSANETLRALTSERAQQLSETLRKIAASKKFTNFNLFYLDFAFQEVVE 357 Query: 186 AYSHT 190 + Sbjct: 358 EWQKM 362 >5U29-A nrPDB Length = 694 Score = 31.1 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 13/64 (20%), Positives = 21/64 (32%), Gaps = 6/64 (9%) Query: 41 RDLPEFGTQGGVHVHKDGLTVTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHG 100 R P G +V + TV W A K + + + + G +HG Sbjct: 53 RPKPHIGPNYESYVKEWAKTVGPNSDEWWAA------KARETLDWYDDFKTVRAGGFEHG 106 Query: 101 SIYW 104 + W Sbjct: 107 DVQW 110 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.302 0.109 0.259 Lambda K H 0.267 0.0333 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,800,370 Number of Sequences: 36641 Number of extensions: 562742 Number of successful extensions: 1572 Number of sequences better than 10.0: 31 Number of HSP's better than 10.0 without gapping: 31 Number of HSP's successfully gapped in prelim test: 20 Number of HSP's that attempted gapping in prelim test: 1446 Number of HSP's gapped (non-prelim): 58 length of query: 536 length of database: 10,336,785 effective HSP length: 102 effective length of query: 434 effective length of database: 6,599,403 effective search space: 2864140902 effective search space used: 2864140902 T: 11 A: 40 X1: 16 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.0 bits) S2: 61 (28.4 bits)