BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= O73790 (410 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2H4P-A nrPDB 758 0.0 2H4Q-A nrPDB 684 0.0 1BY7-A nrPDB 333 9e-92 4ZK0-A nrPDB 317 4e-87 4GA7-A nrPDB 305 2e-83 1HLE-A nrPDB 291 4e-79 1UHG-A nrPDB 285 3e-77 1XQJ-A nrPDB 270 1e-72 6EE5-A nrPDB 266 2e-71 2OL2-A nrPDB 197 5e-51 4EB1-I nrPDB 196 1e-50 1ATT-A nrPDB 192 3e-49 4P0F-A nrPDB 191 7e-49 6HGE-B nrPDB 189 2e-48 3DY0-A nrPDB 187 6e-48 5HGC-A nrPDB 187 6e-48 3NE4-A nrPDB 186 2e-47 3NDA-A nrPDB 186 2e-47 1YXA-A nrPDB 183 1e-46 3F02-A nrPDB 182 2e-46 3LW2-A nrPDB 178 3e-45 1C5G-A nrPDB 176 2e-44 1JMJ-A nrPDB 173 1e-43 1QMB-A nrPDB 172 2e-43 4KDS-A nrPDB 169 2e-42 2XN5-A nrPDB 168 4e-42 3OZQ-A nrPDB 167 1e-41 4Y40-A nrPDB 164 5e-41 4DY0-A nrPDB 164 7e-41 5NCS-A nrPDB 162 3e-40 4DTE-A nrPDB 159 3e-39 4AJT-A nrPDB 157 6e-39 2VDY-A nrPDB 156 2e-38 1JJO-C nrPDB 154 6e-38 3ZHA-A nrPDB 149 2e-36 1C8O-A nrPDB 148 4e-36 1SEK-A nrPDB 143 1e-34 5NCU-A nrPDB 143 2e-34 3LE2-A nrPDB 142 4e-34 2R9Y-A nrPDB 141 4e-34 5INW-A nrPDB 140 1e-33 6F02-A nrPDB 135 3e-32 6CJ7-A nrPDB 134 6e-32 1K9O-I nrPDB 134 1e-31 3PZF-A nrPDB 133 1e-31 4AJU-A nrPDB 132 3e-31 1M93-B nrPDB 130 8e-31 2V95-A nrPDB 121 6e-28 6F4U-A nrPDB 120 9e-28 6BJ5-B nrPDB 115 5e-26 2PEF-A nrPDB 114 5e-26 1IMV-A nrPDB 111 5e-25 3STO-A nrPDB 107 7e-24 2OAY-A nrPDB 107 9e-24 1SNG-A nrPDB 99 3e-21 1MTP-A nrPDB 83 3e-16 5C98-A nrPDB 71 8e-13 5M3Y-A nrPDB 35 0.050 3I44-A nrPDB 32 0.64 2QYS-A nrPDB 29 3.8 4G1P-A nrPDB 28 5.4 5SUM-A nrPDB 28 7.3 >2H4P-A nrPDB Length = 394 Score = 758 bits (1958), Expect = 0.0, Method: Compositional matrix adjust. Identities = 369/369 (100%), Positives = 369/369 (100%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF Sbjct: 26 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 85 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI Sbjct: 86 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 145 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD Sbjct: 146 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 205 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM Sbjct: 206 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 265 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH Sbjct: 266 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 325 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEA 360 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEA Sbjct: 326 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEA 385 Query: 361 AAATAVIIS 369 AAATAVIIS Sbjct: 386 AAATAVIIS 394 >2H4Q-A nrPDB Length = 382 Score = 684 bits (1765), Expect = 0.0, Method: Compositional matrix adjust. Identities = 340/369 (92%), Positives = 340/369 (92%), Gaps = 28/369 (7%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF Sbjct: 42 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 101 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 EQAENIHSGFKELLTAFNKPRNNYSLRSANRI Sbjct: 102 ----------------------------EQAENIHSGFKELLTAFNKPRNNYSLRSANRI 133 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD Sbjct: 134 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 193 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM Sbjct: 194 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 253 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH Sbjct: 254 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 313 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEA 360 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEA Sbjct: 314 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEA 373 Query: 361 AAATAVIIS 369 AATAVIIS Sbjct: 374 VAATAVIIS 382 >1BY7-A nrPDB Length = 382 Score = 333 bits (854), Expect = 9e-92, Method: Compositional matrix adjust. Identities = 165/409 (40%), Positives = 252/409 (61%), Gaps = 28/409 (6%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 ME + + F ++LF L + + +N+F SPWSISS +A+ Y+ ++GST +MA+VL F Sbjct: 1 MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQF 60 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 E A A+ IHS F+ L +A N NY L S N++ Sbjct: 61 NEVGAA------------------------ADKIHSSFRSLSSAINASTGNYLLESVNKL 96 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 + EK+ + Y++L +KYY +EPQ V+F E++RK+IN+WV+ QT+ KI NLL Sbjct: 97 FGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGS 156 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 V TR++LVNA+YFK +W+ F+ + + PFR++ + PV+MMY+R+ + +E + Sbjct: 157 VDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDL 216 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 +++ELPY ++SMF+LLPD+I D +TGLE LE E+TY++L++W M E V+++ Sbjct: 217 KAQILELPYAG-DVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVY 275 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTTN-ADFRGMTDKKDLAISKVIHQSFVAVDEKGTE 359 +P+F LE+ +LR LR+MGM AF A+F GM+++ DL +S+V HQ+ V V+E+GTE Sbjct: 276 IPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTE 335 Query: 360 AAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 AAA T +++ T + +F DHPF F I H + ILFFGRF P Sbjct: 336 AAAGTGGVMTGRTG--HGGPQFVADHPFLFLIMHKITNCILFFGRFSSP 382 >4ZK0-A nrPDB Length = 390 Score = 317 bits (813), Expect = 4e-87, Method: Compositional matrix adjust. Identities = 172/408 (42%), Positives = 254/408 (62%), Gaps = 18/408 (4%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 M +S + F DLF + ++ ++ NIF+SP SI+SAL + L AK +TA+++ +VLHF Sbjct: 1 MNSLSEANTKFMFDLFQQFRKS-KENNIFYSPISITSALGMVLLGAKDNTAQQIKKVLHF 59 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 + V + G+ +D ++ N+H F++LLT FNK + Y L+ AN++ Sbjct: 60 DQ--------VTENTTGKAATYHVD----RSGNVHHQFQKLLTEFNKSTDAYELKIANKL 107 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 + EKTY L YL KK+Y+ + V+F APE+SRK+IN+WVE QT KIKNL+ + Sbjct: 108 FGEKTYLFLQEYLDAIKKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIKNLIPEGN 167 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 + + T L+LVNAIYFK +WE KF E T + F +KN K ++MM +F +E + Sbjct: 168 IGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTSFHFASLEDV 227 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 K++E+PY ++LSM +LLP++I GL++LE +LT E+L EW + M ET VDLH Sbjct: 228 QAKVLEIPYKGKDLSMIVLLPNEID----GLQKLEEKLTAEKLMEWTSLQNMRETRVDLH 283 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEA 360 LP+F +E+ DL+DTLR MGM F +AD GMT + L +S V+H++FV V E+ Sbjct: 284 LPRFKVEESYDLKDTLRTMGMVDIFNGDADLSGMTGSRGLVLSGVLHKAFVEVTEE-GAE 342 Query: 361 AAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 AAA ++ F +S + +F +HPF FFIR NK+ +ILF+GRF P Sbjct: 343 AAAATAVVGFGSSPTSTNEEFHCNHPFLFFIRQNKTNSILFYGRFSSP 390 >4GA7-A nrPDB Length = 389 Score = 305 bits (782), Expect = 2e-83, Method: Compositional matrix adjust. Identities = 178/409 (43%), Positives = 245/409 (59%), Gaps = 31/409 (7%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 MEQ+S++ F +DLF L+E N NIF SP+SISSA+A+ +L +G+TA ++++ HF Sbjct: 11 MEQLSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHF 70 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 E +HS F+ L NK +Y L+ ANR+ Sbjct: 71 N----------------------------TVEEVHSRFQSLNADINKRGASYILKLANRL 102 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 Y EKTY LP +L ++K Y A+ V+F+ A E +RK IN WV+ QTE KI LL+S Sbjct: 103 YGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTINQWVKGQTEGKIPELLASGM 162 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 V T+L+LVNAIYFK W+ KF E T+ PFRL+K K VKMMY + F +E + Sbjct: 163 VDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMMYQKKKFAYGYIEDL 222 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 +++ELPY ELSM ILLPDDI+D +TGL+++E +LT E+L EW + + V++ Sbjct: 223 KCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVS 282 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAF-TTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTE 359 LP+F LE+ L L +G+ F ++ AD GM+ +D+ ISK++H+SFV V+E+GTE Sbjct: 283 LPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGMSGARDIFISKIVHKSFVEVNEEGTE 342 Query: 360 AAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 AAAATA I +F F DHPF FFIRHN S +ILF GRF P Sbjct: 343 AAAATAGIATFCMDDPEE--NFTADHPFLFFIRHNSSGSILFLGRFSSP 389 >1HLE-A nrPDB Length = 345 Score = 291 bits (745), Expect = 4e-79, Method: Compositional matrix adjust. Identities = 155/355 (43%), Positives = 216/355 (60%), Gaps = 29/355 (8%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 MEQ+S + +F VDLF LNE++ NIF SP SISSALA+ +L +G+TA ++++ L+F Sbjct: 2 MEQLSTANTHFAVDLFRALNESDPTGNIFISPLSISSALAMIFLGTRGNTAAQVSKALYF 61 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 + E+IHS F+ L NKP Y L+ ANR+ Sbjct: 62 ----------------------------DTVEDIHSRFQSLNADINKPGAPYILKLANRL 93 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 Y EKTY L +L ++K Y AE V+F+ APE +RKEIN WV+ QTE KI LL Sbjct: 94 YGEKTYNFLADFLASTQKMYGAELASVDFQQAPEDARKEINEWVKGQTEGKIPELLVKGM 153 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 V T+L+LVNAIYFK W+ KF E T PFRL+K +K VKMMY + FP +E + Sbjct: 154 VDNMTKLVLVNAIYFKGNWQQKFMKEATRDAPFRLNKKDTKTVKMMYQKKKFPYNYIEDL 213 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 +++ELPY +ELSM ILLPDDI+D +TGLE++E++LT ++L EW + + V++H Sbjct: 214 KCRVLELPYQGKELSMIILLPDDIEDESTGLEKIEKQLTLDKLREWTKPENLYLAEVNVH 273 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTTN-ADFRGMTDKKDLAISKVIHQSFVAVD 354 LP+F LE+ DL L +G+ F AD GM+ +DL +SK+IH+SFV ++ Sbjct: 274 LPRFKLEESYDLTSHLARLGVQDLFNRGKADLSGMSGARDLFVSKIIHKSFVDLN 328 >1UHG-A nrPDB Length = 385 Score = 285 bits (729), Expect = 3e-77, Method: Compositional matrix adjust. Identities = 145/406 (35%), Positives = 236/406 (58%), Gaps = 24/406 (5%) Query: 4 VSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEA 63 + A+ F D+F +L + ++NIF+ P +I SALA+ YL AK ST ++ +V+ F + Sbjct: 3 IGAASMEFCFDVFKELKVHHANENIFYCPIAIMSALAMVYLGAKDSTRTQINKVVRFDKL 62 Query: 64 VRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVE 123 P G ++ + + N+HS +++L KP + YS A+R+Y E Sbjct: 63 ----------PGFGD----SIEAQCGTSVNVHSSLRDILNQITKPNDVYSFSLASRLYAE 108 Query: 124 KTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKA 183 + Y +LP YLQ K+ Y+ + +NF+TA +Q+R+ IN+WVE QT I+N+L V + Sbjct: 109 ERYPILPEYLQCVKELYRGGLEPINFQTAADQARELINSWVESQTNGIIRNVLQPSSVDS 168 Query: 184 TTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFK 243 T ++LVNAI FK WE F+ E T PFR+++ +SKPV+MMY F V M K Sbjct: 169 QTAMVLVNAIVFKGLWEKAFKDEDTQAMPFRVTEQESKPVQMMYQIGLFRVASMASEKMK 228 Query: 244 MIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPK 303 ++ELP+ +SM +LLPD++ +GLEQLE + +E+L+EW S +M E + ++LP+ Sbjct: 229 ILELPFASGTMSMLVLLPDEV----SGLEQLESIINFEKLTEWTSSNVMEERKIKVYLPR 284 Query: 304 FSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTE-AAA 362 +E++ +L L MG+T F+++A+ G++ + L IS+ +H + ++E G E + Sbjct: 285 MKMEEKYNLTSVLMAMGITDVFSSSANLSGISSAESLKISQAVHAAHAEINEAGREVVGS 344 Query: 363 ATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 A A + + + S +F+ DHPF F I+H + +LFFGR P Sbjct: 345 AEAGVDAASVSE-----EFRADHPFLFCIKHIATNAVLFFGRCVSP 385 >1XQJ-A nrPDB Length = 389 Score = 270 bits (689), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 139/399 (34%), Positives = 230/399 (57%), Gaps = 35/399 (8%) Query: 11 FTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSS 70 F VDLF +L+E N+ FSP ++S++L+L + AKG TA E+ +VLHF Sbjct: 25 FAVDLFKQLSEKEPLGNVLFSPIALSTSLSLAQVGAKGDTANEIGQVLHF---------- 74 Query: 71 VARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLP 130 E +++ GF+ + + NK + YSL+ R+YV+K+ L Sbjct: 75 ------------------ENVKDVPFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLST 116 Query: 131 TYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILV 190 ++ +K+ Y E + V+FK E+++ +IN ++ T+ +N+L+ + V T++++V Sbjct: 117 EFISSTKRPYAKELETVDFKDKLEETKGQINNSIKDLTDGHFENILADNSVNDQTKILVV 176 Query: 191 NAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPYV 250 NA YF +W KF +T PFR++K +KPV+MM M TF + ++ +N K+IELP+ Sbjct: 177 NAAYFVGKWMKKFSESETKESPFRVNKTDTKPVQMMNMEATFSMGNIDSINSKIIELPFQ 236 Query: 251 KRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDRI 310 + LSMFILLP D++D +TGLE++E++L E LS+W + M V L +PKF +E I Sbjct: 237 NKHLSMFILLPKDVEDESTGLEKIEKQLNSESLSQWTNPSTMANAKVKLSIPKFKVEKMI 296 Query: 311 DLRDTLRNMGMTTAFTTN-ADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVIIS 369 D + +L N+G+ F+ + +DF GM++ K +A+S VIH+ + + E G ++ Sbjct: 297 DPKASLENLGLKHIFSEDTSDFSGMSETKGVALSNVIHKVSLEITEDGGDSIEVPGA--- 353 Query: 370 FTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 ++ H + DHPF + IRHNK++ I+FFG+F P Sbjct: 354 ---RILQHKDELNADHPFIYIIRHNKTRNIIFFGKFSSP 389 >6EE5-A nrPDB Length = 379 Score = 266 bits (679), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 160/402 (39%), Positives = 235/402 (58%), Gaps = 52/402 (12%) Query: 10 NFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESS 69 +F L+ +L +++ DKNIFFSP SISSALA+ L AKG T ++ E L F Sbjct: 27 DFAFSLYRELAKSSPDKNIFFSPVSISSALAMLSLGAKGDTHTQILEGLGFNSEA----- 81 Query: 70 SVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALL 129 +IH GF+ LL N+P+ L++AN ++V+K+ LL Sbjct: 82 -----------------------DIHQGFQHLLQTLNRPKG-LQLKTANGLFVDKSLKLL 117 Query: 130 PTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLIL 189 ++L+ SKK Y+AE V+F PE+++K+IN WVEKQT KIK+LL D+ + T L+L Sbjct: 118 DSFLEDSKKLYQAEAFSVDFD--PEEAKKQINDWVEKQTNGKIKDLLK--DLDSDTVLVL 173 Query: 190 VNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPY 249 VNAIYFK +W+ F E T + F + + + V MM + F ++++ K++ELPY Sbjct: 174 VNAIYFKGKWKKPFDPENTKEEDFHVDEKTTVKVPMMSQKGKFYYYHDDELSCKVLELPY 233 Query: 250 VKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDR 309 K SM I+LPD+ GL+ LE+ LT E LS+W K +T V+L+LPKF +E Sbjct: 234 -KGNASMLIILPDE-----GGLQHLEQSLTPETLSKWL--KSLTRRSVELYLPKFKIEGT 285 Query: 310 IDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAAT---AV 366 DL++ L N+G+T F+ AD G+T++K L +SK +H++ + V+E+GTEAAAAT A+ Sbjct: 286 YDLKEVLSNLGITDLFSPGADLSGITEEK-LYVSKAVHKAVLEVNEEGTEAAAATFLEAI 344 Query: 367 IISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 +S +FK D PF F IR NK+ +ILF G+ P Sbjct: 345 PMSIPP-------EFKADRPFLFLIRENKTGSILFMGKVVNP 379 >2OL2-A nrPDB Length = 395 Score = 197 bits (502), Expect = 5e-51, Method: Compositional matrix adjust. Identities = 125/399 (31%), Positives = 209/399 (52%), Gaps = 39/399 (9%) Query: 10 NFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESS 69 +FT DL+ L +NIFFSP SIS +LA+ L A ST ++ E L Sbjct: 36 DFTFDLYRALASAAPSQNIFFSPVSISMSLAMLSLGAGSSTKMQILEGLG---------- 85 Query: 70 SVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALL 129 ++ + + +H GF++LL N+PR+ + L N ++ + L Sbjct: 86 --------------LNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQ 131 Query: 130 PTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLIL 189 T++ K Y A+ NF+ + + K+IN +V KQT+ KI +LL + D A +I+ Sbjct: 132 DTFVSAMKTLYLADTFPTNFRDSAG-AMKQINDYVAKQTKGKIVDLLKNLDSNAV--VIM 188 Query: 190 VNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPY 249 VN I+FKA+WE F + T Q F ++ V MM D + L+ ++ +++ +PY Sbjct: 189 VNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPY 248 Query: 250 VKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDR 309 ++FIL P + K ++Q+E L+ + L +W KM + ++L+LPKFS+E Sbjct: 249 QGNATALFIL-PSEGK-----MQQVENGLSEKTLRKWL--KMFKKRQLELYLPKFSIEGS 300 Query: 310 IDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVIIS 369 L L ++G++ FT++AD G+++ ++ +S+++H++ V VDE GT AAAAT I + Sbjct: 301 YQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFT 360 Query: 370 FTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 F ++ +N + + PF FI N ILF G+ P Sbjct: 361 FRSARLNSQ-RLVFNRPFLMFIVDN---NILFLGKVNRP 395 >4EB1-I nrPDB Length = 440 Score = 196 bits (499), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 134/420 (31%), Positives = 219/420 (52%), Gaps = 44/420 (10%) Query: 3 QVSASIGNFTVDLFNKLNET-NRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFT 61 ++S + F + L ++ N + NIF SP SIS+A A+T L A T +++ EV F Sbjct: 50 ELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKF- 108 Query: 62 EAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYS-LRSANRI 120 + + ++S + IH F +L + N S L SANR+ Sbjct: 109 DTISEKTS----------------------DQIHFFFAKLNCRLYRKANKASKLVSANRL 146 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 + +K+ TY +S+ Y A+ Q ++FK EQSR IN WV +TE +I +++ S+ Sbjct: 147 FGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEA 206 Query: 181 V--------KATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTF 232 + + +T L+LVN IYFK W+ KF E T + F + +S MMY F Sbjct: 207 INVLVLVNTRTSTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKF 266 Query: 233 PVLIMEKMNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMM 292 + + +++ELP+ +++M ++LP K L ++E+ELT E L EW D + Sbjct: 267 RYRRVAE-GTQVLELPFKGDDITMVLILPKPEK----SLAKVEKELTPEVLQEWLDE--L 319 Query: 293 TETLVDLHLPKFSLEDRIDLRDTLRNMGMTTAFTTN-ADFRGMT--DKKDLAISKVIHQS 349 E ++ +H+P+F +ED L++ L++MG+ F+ + G+ + DL +S H++ Sbjct: 320 EEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKA 379 Query: 350 FVAVDEKGTEAAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 F+ V+E+G+EAAA+TAV+I+ + N V FK + PF FIR TI+F GR P Sbjct: 380 FLEVNEEGSEAAASTAVVIAGRSLNPNRV-TFKANRPFLVFIREVPLNTIIFMGRVANPC 438 >1ATT-A nrPDB Length = 429 Score = 192 bits (487), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 129/412 (31%), Positives = 217/412 (52%), Gaps = 36/412 (8%) Query: 3 QVSASIGNFTVDLFNKLNET-NRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFT 61 ++S + +F + L ++ N + NIF SP SIS+A A+T L A +T ++ EV F Sbjct: 47 ELSKANSHFATAFYQHLADSKNNNDNIFLSPLSISTAFAMTKLGACNNTLTQLMEVFKF- 105 Query: 62 EAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKEL-LTAFNKPRNNYSLRSANRI 120 + + ++S + IH F +L + K + L SANR+ Sbjct: 106 DTISEKTS----------------------DQIHFFFAKLNCRLYRKANKSSELVSANRL 143 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 + +K+ TY +S+ Y A+ Q ++FK EQSR IN W+ +TE +I +++ Sbjct: 144 FGDKSITFNETYQDISEVVYGAKLQPLDFKGNAEQSRLTINQWISNKTEGRITDVIPPQA 203 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 + T L+LVN IYFK W+ KF E T + F + +S V MMY F + + Sbjct: 204 INEFTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSVLMMYQESKFRYRRVAES 263 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 +++ELP+ +++M ++LP K L ++E+ELT + L EW D +TETL+ +H Sbjct: 264 T-QVLELPFKGDDITMVLILPKLEKT----LAKVEQELTPDMLQEWLDE--LTETLLVVH 316 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTTN-ADFRGMT--DKKDLAISKVIHQSFVAVDEKG 357 +P+F +ED +++ L++MG+ F+ + G+ + DL +S H++F+ V+E+G Sbjct: 317 MPRFRIEDSFSVKEQLQDMGLEDLFSPEKSRLPGIVAEGRSDLYVSDAFHKAFLEVNEEG 376 Query: 358 TEAAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 +EAAA+T + I+ S+ + + FK + PF IR TI+F GR P Sbjct: 377 SEAAASTVISIA-GRSLNSDRVTFKANRPFLVLIREVALNTIIFMGRVANPC 427 >4P0F-A nrPDB Length = 393 Score = 191 bits (484), Expect = 7e-49, Method: Compositional matrix adjust. Identities = 125/396 (31%), Positives = 210/396 (53%), Gaps = 40/396 (10%) Query: 11 FTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSS 70 F+++++ KL+ +NI FSP+SI + A+ L A+ TA ++ + L + Sbjct: 17 FSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQLDQGLGLASS------- 69 Query: 71 VARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLP 130 DPE I F ++L A+ +++ LR AN+I+V Y L Sbjct: 70 --------------DPE-----QIAHSFHQVLAAY---QDSQILRIANKIFVMDGYQLRQ 107 Query: 131 TYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILV 190 + QL K + + Q V+F + Q+ IN WVE++T IK+L+ +D + + +RL+LV Sbjct: 108 EFDQLLSKQFLSAAQSVDF-SKNVQAAATINNWVEQRTNHLIKDLVPADVLNSESRLVLV 166 Query: 191 NAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPYV 250 NAI+FK W+ +F T F L ++ V MM +++ F + ++ +ELPY Sbjct: 167 NAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQVPMMSLKERFRYADLPALDAMALELPYK 226 Query: 251 KRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDRI 310 +LSM I+LP+ TGL LE +L LS+ S + ET V L LP+F E ++ Sbjct: 227 DSDLSMLIVLPNT----KTGLPALEEKLRLTTLSQITQS--LYETKVALKLPRFKAEFQV 280 Query: 311 DLRDTLRNMGMTTAFTTNADFRGMTDKKD-LAISKVIHQSFVAVDEKGTEAAAATAVIIS 369 +L + + +GM+ F+ A+F M + L +S +IH++F+ V+E+GTEAAAAT + + Sbjct: 281 ELSEVFQKLGMSRMFSDQAEFGKMLQSPEPLKVSAIIHKAFIEVNEEGTEAAAATGMAVR 340 Query: 370 FTTSVIN--HVLKFKVDHPFHFFIRHNKSKTILFFG 403 ++++ ++F DHPF + + H K LF+G Sbjct: 341 RKRAIMSPEEPIEFFADHPFTYVLVHQKDLP-LFWG 375 >6HGE-B nrPDB Length = 409 Score = 189 bits (481), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 129/402 (32%), Positives = 211/402 (52%), Gaps = 39/402 (9%) Query: 10 NFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF--TEAVRAE 67 +F L+ +L DKN+ FSP SIS+ALA L A +T E+ + L F TE AE Sbjct: 41 DFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAE 100 Query: 68 SSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYA 127 IH F+ LL N+ + L N ++V++ + Sbjct: 101 --------------------------IHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLS 134 Query: 128 LLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRL 187 LL + + +K+ Y +E +F+ + ++K IN +V+ T KI +L+ D+ + T + Sbjct: 135 LLDRFTEDAKRLYGSEAFATDFQDSA-AAKKLINDYVKNGTRGKITDLIK--DLDSQTMM 191 Query: 188 ILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRD-TFPVLIMEKMNFKMIE 246 +LVN I+FKA+WE+ F + T F LSK K V MM + T P E+++ +++ Sbjct: 192 VLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVQ 251 Query: 247 LPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSL 306 L Y ++FIL PD K +E++E L+ E L+ W DS E + +L+LPKFS+ Sbjct: 252 LNYTGNASALFIL-PDQDK-----MEEVEAMLSRETLNRWGDSLEFRE-IGELYLPKFSI 304 Query: 307 EDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAV 366 +L D L +G+ AFT+ AD G+T ++LA+S+V+H++ + V E+GTEA+AATAV Sbjct: 305 SRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQVVHKAVLDVFEEGTEASAATAV 364 Query: 367 IISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 I+ ++++ + + PF I + + +I F + P Sbjct: 365 KITLLSALVETRTIVRFNRPFLMIIVDHFTWSIFFMSKVTNP 406 >3DY0-A nrPDB Length = 336 Score = 187 bits (476), Expect = 6e-48, Method: Compositional matrix adjust. Identities = 114/361 (31%), Positives = 192/361 (53%), Gaps = 35/361 (9%) Query: 10 NFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESS 69 +FT DL+ L +NIFFSP SIS +LA+ L A ST ++ E L Sbjct: 11 DFTFDLYRALASAAPSQNIFFSPVSISMSLAMLSLGAGSSTKMQILEGLG---------- 60 Query: 70 SVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALL 129 ++ + + +H GF++LL N+PR+ + L N ++ + L Sbjct: 61 --------------LNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQ 106 Query: 130 PTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLIL 189 T++ K Y A+ NF+ + + K+IN +V KQT+ KI +LL + D A +I+ Sbjct: 107 DTFVSAMKTLYLADTFPTNFRDSAG-AMKQINDYVAKQTKGKIVDLLKNLDSNAV--VIM 163 Query: 190 VNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPY 249 VN I+FKA+WE F + T Q F ++ V MM D + L+ ++ +++ +PY Sbjct: 164 VNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPY 223 Query: 250 VKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDR 309 ++FIL P + K ++Q+E L+ + L +W KM + ++L+LPKFS+E Sbjct: 224 QGNATALFIL-PSEGK-----MQQVENGLSEKTLRKWL--KMFKKRQLELYLPKFSIEGS 275 Query: 310 IDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVIIS 369 L L ++G++ FT++AD G+++ ++ +S+++H++ V VDE GT AAAAT I + Sbjct: 276 YQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFT 335 Query: 370 F 370 F Sbjct: 336 F 336 >5HGC-A nrPDB Length = 380 Score = 187 bits (476), Expect = 6e-48, Method: Compositional matrix adjust. Identities = 130/405 (32%), Positives = 202/405 (49%), Gaps = 49/405 (12%) Query: 9 GNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF--TEAVRA 66 +F F ++ + +KNIF+SP SIS+A A+ L A+ +T ++ E L F TE Sbjct: 16 ADFAFQFFREVTQEAPNKNIFYSPVSISTAFAMLALGARSATQSQILEGLAFNLTEI--- 72 Query: 67 ESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTY 126 Q + IH GF L+ N P L N I+V Sbjct: 73 -----------------------QEKEIHEGFHNLIHMLNHPEGGVQLNMMNAIFVTAAL 109 Query: 127 ALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTR 186 ALL +L +K Y+ E +F P ++ K+IN ++E++T KI NL+ D+ T Sbjct: 110 ALLRKFLDDAKALYQLEAFTTDFN-KPTEAEKQINDYIERKTHGKITNLVK--DMDPQTV 166 Query: 187 LILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIE 246 ++L + +YFK WE F+AE T + F + + V MMY F E+++ ++ Sbjct: 167 MLLASFVYFKGSWEKPFEAEHTEEREFFVDAETTVKVPMMYQMGRFDFYFDEELSCTVVR 226 Query: 247 LPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSL 306 L Y + F++LP K ++QLE+ L E + +W+D + + ++L+ PKFS+ Sbjct: 227 LHY-NGSATAFLVLPAKGK-----MKQLEQTLDKETIQKWSDH--LFQRFMNLYFPKFSI 278 Query: 307 EDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAV 366 ++ +TLR MG+ FT AD G+T DL +SKV+H++ + VDEKGTEAAAATAV Sbjct: 279 SGSYEISNTLRKMGIVDVFTNQADLSGITGSPDLKVSKVVHKASLDVDEKGTEAAAATAV 338 Query: 367 ---IISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 ISF ++ + HPF I + + LF G+ P Sbjct: 339 EIMPISFPPTI-------EFSHPFLMLIFDRDTNSTLFIGKIVNP 376 >3NE4-A nrPDB Length = 424 Score = 186 bits (472), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 125/413 (30%), Positives = 210/413 (50%), Gaps = 49/413 (11%) Query: 3 QVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF-- 60 +++ ++ F L+ +L + NIFFSP SI++A A+ L K T E+ E L+F Sbjct: 55 KITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNL 114 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 TE A+ IH GF+ELL N+P + L + N + Sbjct: 115 TEIPEAQ--------------------------IHEGFQELLRTLNQPDSQLQLTTGNGL 148 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 ++ + L+ +L+ KK Y +E VNF E+++K+IN +VEK T+ KI +L+ D Sbjct: 149 FLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDT-EEAKKQINDYVEKGTQGKIVDLVKELD 207 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 T LVN I+FK +WE F+ + T + F + + + V MM F + +K+ Sbjct: 208 --RDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKL 265 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 + ++ + Y+ ++F LPD+ K L+ LE ELT++ ++++ +++ LH Sbjct: 266 SSWVLLMKYLGNATAIF-FLPDEGK-----LQHLENELTHDIITKFLENE--DRRSASLH 317 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEA 360 LPK S+ DL+ L +G+T F+ AD G+T++ L +SK +H++ + +DEKGTEA Sbjct: 318 LPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEA 377 Query: 361 AAAT---AVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPVE 410 A A A+ +S V K + PF F + +K+ LF G+ P + Sbjct: 378 AGAMFLEAIPMSIPPEV-------KFNKPFVFLMIEQNTKSPLFMGKVVNPTQ 423 >3NDA-A nrPDB Length = 377 Score = 186 bits (471), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 118/380 (31%), Positives = 197/380 (51%), Gaps = 33/380 (8%) Query: 25 DKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSSVARPSRGRPKRRRM 84 +KN+FFSP+S+S+A+ + + A+G T +E+++ L F++ ++ + Sbjct: 27 EKNVFFSPYSVSTAMGMAFAGARGQTQQELSQGLGFSDVDLTDAGV-------------L 73 Query: 85 DPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTYLQLSKKYYKAEP 144 D E + S P N+ +L AN +++T ALL +Y + + AE Sbjct: 74 DAYTHHTERLKS----------TPSNS-TLDVANAAAIQRTLALLNSYESALQSSFGAEL 122 Query: 145 QKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILVNAIYFKAEWEVKFQ 204 KV+F P+ + +N WV+++T KI+ L ++ + T L+L+NAIYFK EW F Sbjct: 123 HKVDFAGEPQAAVDFVNNWVKRKTHDKIEKLF-NEPLDPDTLLVLLNAIYFKGEWNTAFV 181 Query: 205 AEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPYVKRELSMFILLPDDI 264 E T + F V M + + + +++ELPY + +M ILLP + Sbjct: 182 KEHTEKRQFFNGGVTPVEVDTMRLEARIKYRFFDDLQVEVVELPYRGLDYTMAILLPKE- 240 Query: 265 KDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDRIDLRDTLRNMGMTTA 324 TG+E L++ LT +R + + E + + LPKF LE + L+ L+++G+ Sbjct: 241 ---NTGVEGLKQNLTIDRFQNYLSD--LRERKITVLLPKFKLETKYSLKAPLQSLGIKQI 295 Query: 325 FTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVIISFTTSVINHVLKFKVD 384 F + AD G+ D L +S V H++ V V+E+GT AAA T V+I S+ + F+VD Sbjct: 296 FESGADLSGINDGS-LRVSAVEHKAVVEVNEEGTVAAATTGVVI-VPYSLGPEPVVFRVD 353 Query: 385 HPFHFFIRHNKSKTILFFGR 404 HPF FFIR+ ++ I F G+ Sbjct: 354 HPFLFFIRNTRTDDIFFVGQ 373 >1YXA-A nrPDB Length = 398 Score = 183 bits (464), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 121/350 (34%), Positives = 184/350 (52%), Gaps = 36/350 (10%) Query: 6 ASIG-NFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAV 64 ASI +F L+ +L N D NI FSP SIS+ALAL L AKG+T E+ E L F Sbjct: 28 ASINTDFAFSLYKELVLKNPDTNIVFSPLSISAALALVSLGAKGNTLEEILEGLKFNLTE 87 Query: 65 RAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEK 124 +E+ +IH GF LL N+P++ + + + +++EK Sbjct: 88 TSEA------------------------DIHQGFGHLLQRLNQPKDQVQISTGSALFIEK 123 Query: 125 TYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKAT 184 +L + + +K Y+AE +F+ P Q++K IN +V KQT+ IK L+S D+ Sbjct: 124 RQQILTEFQEKAKTLYQAEAFTADFQ-QPRQAKKLINDYVRKQTQGMIKELVS--DLDKR 180 Query: 185 TRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRD-TFPVLIMEKMNFK 243 T ++LVN IYFKA+W+V F T F K + V MM M D T P E+++ Sbjct: 181 TLMVLVNYIYFKAKWKVPFDPLDTFKSEFYCGKRRPVIVPMMSMEDLTTPYFRDEELSCT 240 Query: 244 MIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPK 303 ++EL Y ++FIL PD + ++Q+E L E L +W +S + + +LHLPK Sbjct: 241 VVELKYTGNASALFIL-PDQGR-----MQQVEASLQPETLRKWKNS-LKPRMIDELHLPK 293 Query: 304 FSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAV 353 FS+ L D L +G+ F+T AD +T KDL +S+V+H++ + V Sbjct: 294 FSISTDYSLEDVLSKLGIREVFSTQADLSAITGTKDLRVSQVVHKAVLDV 343 >3F02-A nrPDB Length = 359 Score = 182 bits (462), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 110/367 (29%), Positives = 192/367 (52%), Gaps = 39/367 (10%) Query: 7 SIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRA 66 +I + +V+++N+L T D+NI FSP SI+ A+ + L A+GST +E+ + + Sbjct: 22 AIADLSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLKNG 81 Query: 67 ESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTY 126 E S + F ++TA + Y ++ AN ++V+ + Sbjct: 82 EEFSFLKE-----------------------FSNMVTA---KESQYVMKIANSLFVQNGF 115 Query: 127 ALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTR 186 + +LQ+ KKY+ A V+F + IN WVE T + +K+L+S D A T Sbjct: 116 HVNEEFLQMMKKYFNAAVNHVDFSQNVAVANY-INKWVENNTNNLVKDLVSPRDFDAATY 174 Query: 187 LILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMN----- 241 L L+NA+YFK W+ +F+ E T F + MMY + F + Sbjct: 175 LALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGG 234 Query: 242 -FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 ++++E+PY E+SM ++L L LE + + + EWA+S + + V+++ Sbjct: 235 IYQVLEIPYEGDEISMMLVLSRQ----EVPLATLEPLVKAQLVEEWANS--VKKQKVEVY 288 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEA 360 LP+F++E IDL+D L+ +G+T F +A+ G++D K++ +SK IH+SF+ V+E+G+EA Sbjct: 289 LPRFTVEQEIDLKDVLKALGITEIFIKDANLTGLSDNKEIFLSKAIHKSFLEVNEEGSEA 348 Query: 361 AAATAVI 367 AA + +I Sbjct: 349 AAVSGMI 355 >3LW2-A nrPDB Length = 379 Score = 178 bits (452), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 121/403 (30%), Positives = 205/403 (50%), Gaps = 41/403 (10%) Query: 10 NFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESS 69 +F V +F ++ + ++D+N+ FSP+ +SS LA+ + G T R++ + + F + + Sbjct: 14 DFGVKVFQQVVQASKDRNVVFSPYGVSSVLAMLQMTTAGKTRRQIQDAMGFKVNEKGTAH 73 Query: 70 SVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALL 129 ++ + S KEL+ P N + +A+ I+V++ L+ Sbjct: 74 ALRQLS-----------------------KELM----GPWNKNEISTADAIFVQRDLELV 106 Query: 130 PTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLIL 189 ++ K ++ ++V+F E++R IN WVE+ T+ I +LL+ V TRL+L Sbjct: 107 QGFMPHFFKLFQTMVKQVDFSEV-ERARFIINDWVERHTKGMINDLLAKGAVDELTRLVL 165 Query: 190 VNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTF---PVLIMEKMNFKMIE 246 VNA+YF +W+ F T + F S + V MM + F + + + ++E Sbjct: 166 VNALYFSGQWKTPFLEASTHQRLFHKSDGSTVSVPMMAQSNKFNYTEFTTPDGLEYDVVE 225 Query: 247 LPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSL 306 LPY LSMFI P + KD L L L E + +W + MT L LPKFSL Sbjct: 226 LPYQGDTLSMFIAAPFE-KD--VHLSALTNILDAELIRQWKGN--MTRLPRLLILPKFSL 280 Query: 307 EDRIDLRDTLRNMGMTTAFT-TNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATA 365 E +DLR L +GM F+ T ADF ++D++ L++++ + + + V+E GT A+++TA Sbjct: 281 ETEVDLRGPLEKLGMPDMFSATLADFTSLSDQEQLSVAQALQKVRIEVNESGTVASSSTA 340 Query: 366 VIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 +IS + V +D F F +RHN ++TILF G+ P Sbjct: 341 FVISARMAPTEMV----IDRSFLFVVRHNPTETILFMGQVMEP 379 >1C5G-A nrPDB Length = 402 Score = 176 bits (446), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 119/403 (29%), Positives = 203/403 (50%), Gaps = 41/403 (10%) Query: 10 NFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESS 69 +F V +F ++ + ++D+N+ FSP+ ++S LA+ L G T +++ + F + + Sbjct: 37 DFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGF----KIDDK 92 Query: 70 SVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALL 129 +A P R + +KEL+ +NK + + + I+V++ L+ Sbjct: 93 GMA------PALRHL-------------YKELMGPWNKDE----ISTTDAIFVQRDLKLV 129 Query: 130 PTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLIL 189 ++ + +++ ++V+F E++R IN WV+ T+ I NLL V TRL+L Sbjct: 130 QGFMPHFFRLFRSTVKQVDFSEV-ERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVL 188 Query: 190 VNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTF---PVLIMEKMNFKMIE 246 VNA+YF +W+ F T + F S + V MM + F + + ++E Sbjct: 189 VNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILE 248 Query: 247 LPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSL 306 LPY LSMFI P + L L L+ + +S W + MT L LPKFSL Sbjct: 249 LPYHGDTLSMFIAAP---YEKEVPLSALTNILSAQLISHWKGN--MTRLPRLLVLPKFSL 303 Query: 307 EDRIDLRDTLRNMGMTTAFTT-NADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATA 365 E +DLR L N+GMT F ADF ++D++ L +++ + + + V+E GT A+++TA Sbjct: 304 ETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTA 363 Query: 366 VIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 VI+S + ++ D PF F +RHN + T+LF G+ P Sbjct: 364 VIVSARMAPEEIIM----DRPFLFVVRHNPTGTVLFMGQVMEP 402 >1JMJ-A nrPDB Length = 480 Score = 173 bits (438), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 119/400 (29%), Positives = 202/400 (50%), Gaps = 38/400 (9%) Query: 11 FTVDLFNKL-NETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESS 69 F +L+ L ++ N NIF +P IS+A+ + L KG T ++ +LHF + V A S Sbjct: 114 FAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSK 173 Query: 70 SVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALL 129 + IH+ F++L + Y+LRS N +Y++K + +L Sbjct: 174 Y-------------------EITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPIL 214 Query: 130 PTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLIL 189 + ++YY AE Q +F S+ N + K T+ IK+ L +++ T++++ Sbjct: 215 LDFKTKVREYYFAEAQIADFSDPAFISKT--NNHIMKLTKGLIKDAL--ENIDPATQMMI 270 Query: 190 VNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPY 249 +N IYFK W KF E T FRL++ + V MM + F ++++ +++L Y Sbjct: 271 LNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEY 330 Query: 250 VKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDR 309 V +SM I++P + +G++ LE +LT + W K MT ++ LPKF LE Sbjct: 331 VG-GISMLIVVPHKM----SGMKTLEAQLTPRVVERW--QKSMTNRTREVLLPKFKLEKN 383 Query: 310 IDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAV-II 368 +L ++L+ MG+ F N + G++D++ +AI HQ + V+E+GT+A T V + Sbjct: 384 YNLVESLKLMGIRMLFDKNGNMAGISDQR-IAIDLFKHQGTITVNEEGTQATTVTTVGFM 442 Query: 369 SFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 +T V +F VD PF F I +++ +LF GR P Sbjct: 443 PLSTQV-----RFTVDRPFLFLIYEHRTSCLLFMGRVANP 477 >1QMB-A nrPDB Length = 326 Score = 172 bits (437), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 111/361 (30%), Positives = 190/361 (52%), Gaps = 37/361 (10%) Query: 3 QVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTE 62 +++ ++ F L+ +L + NIFFSP SI++A A+ L K T E+ E L+F Sbjct: 1 KITPNLAEFAFSLYRQLAHQSS-TNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNL 59 Query: 63 AVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYV 122 E++ IH GF+ELL N+P + L + N +++ Sbjct: 60 TEIPEAA------------------------IHEGFQELLRTLNQPDSQLQLTTGNGLFL 95 Query: 123 EKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVK 182 + L+ +L+ KK Y +E VNF E+++K+IN +VEK T+ KI +L+ D Sbjct: 96 SEGLKLVDKFLEDVKKLYHSEAFTVNFGDT-EEAKKQINDYVEKGTQGKIVDLVKELD-- 152 Query: 183 ATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNF 242 T LVN I+FK +WE F+ + T + F + + + V MM F + +K++ Sbjct: 153 RDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSS 212 Query: 243 KMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLP 302 ++ + Y+ ++F LPD+ K L+ LE ELT++ ++++ ++ + +L HLP Sbjct: 213 WVLLMKYLGNATAIF-FLPDEGK-----LQHLENELTHDIITKFLENDRRSASL---HLP 263 Query: 303 KFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAA 362 K S+ DL+ L +G+T F+ AD G+T++ L +SK +H++ + +DEKGTEAA Sbjct: 264 KLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAG 323 Query: 363 A 363 A Sbjct: 324 A 324 >4KDS-A nrPDB Length = 386 Score = 169 bits (428), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 112/406 (27%), Positives = 204/406 (50%), Gaps = 50/406 (12%) Query: 10 NFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESS 69 +F + +F+++ + ++ N+ FSP+ +++ LA+ L A G+T + + L F+ Sbjct: 21 DFGMRVFSQVAQNSKGSNLAFSPYGVATILAMAQLGAGGNTLKTLNAKLGFS-------- 72 Query: 70 SVARPSRGRPKRRRM---DPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTY 126 RG +++R+ D E+ + SG + VE+ Sbjct: 73 ---LQERGMARQQRLLQRDISSEEGVELASG----------------------VMVERKM 107 Query: 127 ALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTR 186 AL + + K ++A P +++F + P+Q+ IN WV T I + LSS + TR Sbjct: 108 ALEKGFRRGLGKAFQASPHQLDF-SRPDQALDIINAWVSDHTAGTIPSFLSSGALTDETR 166 Query: 187 LILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTF---PVLIMEKMNFK 243 ++L+NA++F+ W+V F + T + F + S PV MM + F + + +++ Sbjct: 167 MVLLNALHFQGLWKVPFDPKMTEERLFHCANGSSVPVPMMRLTHRFKYGEFVTPDGVDYD 226 Query: 244 MIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPK 303 +IE+PY LSM ++ P + + T + L ELT +RL +W + M L LP+ Sbjct: 227 VIEVPYEGESLSMLLVSPFEPE---TPVSSLSSELTTQRLQQW--RQEMRSVKRQLVLPR 281 Query: 304 FSLEDRIDLRDTLRNMGMTTAFT-TNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAA 362 F+L+ ++L+ L MG+ F ADF +T ++ L +SKV+ + + V+E+GT+A+A Sbjct: 282 FTLDSEVELKSILIQMGLGDMFNLAKADFTRITTEQPLCVSKVLQKVKIEVNEEGTKASA 341 Query: 363 ATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 ATA I+ F+ + + ++ PF F I H + +LF G+ P Sbjct: 342 ATAAIL-FSRMAVEEI---TMNRPFLFLIHHKSTGAVLFMGQVNQP 383 >2XN5-A nrPDB Length = 350 Score = 168 bits (425), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 112/358 (31%), Positives = 182/358 (50%), Gaps = 40/358 (11%) Query: 9 GNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF--TEAVRA 66 +F +L+ + DKNIFFSP SIS+AL + A ST E+ E L F T+ Sbjct: 16 ADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMV 75 Query: 67 ESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTY 126 E I GF+ L+ + N P+ L+ N +++ K Sbjct: 76 E--------------------------IQHGFQHLICSLNFPKKELELQIGNALFIGKHL 109 Query: 127 ALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTR 186 L +L K Y+ E +F +++EIN+ VE QT+ K+ L+ D+K T Sbjct: 110 KPLAKFLNDVKTLYETEVFSTDFSNI-SAAKQEINSHVEMQTKGKVVGLI--QDLKPNTI 166 Query: 187 LILVNAIYFKAEWEVKFQAEKT-SIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMI 245 ++LVN I+FKA+W F KT F + K + V MM+ + + L+ ++N ++ Sbjct: 167 MVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVL 226 Query: 246 ELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFS 305 ++ Y K L++F+L P K+G +E +E ++ + L +W ++++ + VDL +PKFS Sbjct: 227 QMDYSKNALALFVL-P---KEGQ--MESVEAAMSSKTLKKW--NRLLQKGWVDLFVPKFS 278 Query: 306 LEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAA 363 + DL TL MG+ A++ NADF G+T+ L +S H++ + + EKGTEAA A Sbjct: 279 ISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEKGTEAAGA 336 >3OZQ-A nrPDB Length = 376 Score = 167 bits (422), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 124/407 (30%), Positives = 214/407 (52%), Gaps = 46/407 (11%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 +++ ++ +FT ++ ++ +T + N SP+S ++ LAL +G TA E+ +VLHF Sbjct: 8 LQEFPNAVNSFTPSVYKEVLKTEK-ANFLVSPFSAATLLALAQSGCRGDTAEEIRQVLHF 66 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 + E+AE KE+L+ Y+L +AN+I Sbjct: 67 V------------------------GDREKAE---GAVKEVLSKLT--NEEYTLHTANKI 97 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 YV+ +++ + +++ + Y A+ + V+F + + K +N WVE+QT+ KI+NL+ + Sbjct: 98 YVKTNFSVREEFQKIAVEVYGAQSENVDF-SEKNDAAKLMNAWVEEQTQHKIQNLVDPEI 156 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDT-FPVLIMEK 239 + TR++L+NA+YF A+W V F T F S + V MY+ + F Sbjct: 157 LNNLTRVVLINALYFNAKWLVPFPPFHTRKSDFHKSAKEVVQVDTMYLDEQYFNYYECHH 216 Query: 240 MNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDL 299 ++ K++ELP+ K S+ I+L + I+ GL LE ++ L +T+ LV++ Sbjct: 217 LDAKLLELPF-KGGASLTIVLSNQIE----GLVSLESKIKRSFLPH-----NLTKQLVNV 266 Query: 300 HLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMT-DKKDLAISKVIHQSFVAVDEKGT 358 LPKF +E +D + L+ +G+ AF AD G+ +K DL IS ++ +SF+ V E+G Sbjct: 267 ALPKFKIESTVDFKKVLKKLGVKKAFGDEADLSGIAGEKGDLVISNIVQKSFIDVSEEGV 326 Query: 359 EAAAATAV-IISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGR 404 EAAAAT + +I ++ + +F VDHPF F+I+ ILF GR Sbjct: 327 EAAAATYIPVILPEMALPDSPKQFIVDHPFIFYIK--VKGMILFAGR 371 >4Y40-A nrPDB Length = 414 Score = 164 bits (416), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 109/395 (27%), Positives = 197/395 (49%), Gaps = 41/395 (10%) Query: 15 LFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSSVARP 74 L KL N +NIF SP SIS+A ++ L A+ ST E+ + +F Sbjct: 59 LLKKLAFYNPGRNIFLSPLSISTAFSMLCLGAQDSTLDEIKQGFNF-------------- 104 Query: 75 SRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTYLQ 134 R+M PE +++H GF ++ + + L N +++++ +L+ Sbjct: 105 -------RKM-PE----KDLHEGFHYIIHELTQKTQDLKLSIGNTLFIDQRLQPQRKFLE 152 Query: 135 LSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILVNAIY 194 +K +Y AE NF+ E ++K+IN ++ ++T KI NL+ +++ T ++L N I+ Sbjct: 153 DAKNFYSAETILTNFQNL-EMAQKQINDFISQKTHGKINNLI--ENIDPGTVMLLANYIF 209 Query: 195 FKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPYVKREL 254 F+A W+ +F T + F L KN S V MM+ + V +K++ ++E+PY K Sbjct: 210 FRARWKHEFDPNVTKEEDFFLEKNSSVKVPMMFRSGIYQVGYDDKLSCTILEIPYQKNIT 269 Query: 255 SMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDRIDLRD 314 ++FI LPD+ K L+ LE+ L + S W +++ +V + +P+ + DL+ Sbjct: 270 AIFI-LPDEGK-----LKHLEKGLQVDTFSRW--KTLLSRRVVCVSVPRLHMTGTFDLKK 321 Query: 315 TLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVIISFTTSV 374 TL +G++ F + D + + L + + +H++ + +DE+GTE AA T T Sbjct: 322 TLSYIGVSKIFEEHGDLTKIAPHRSLKVGEAVHKAELKMDERGTEGAAGTGA----QTLP 377 Query: 375 INHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 + L K+D P+ I K ++LF G+ P+ Sbjct: 378 METPLCVKIDKPYLLLIYSEKIPSVLFLGKIVNPI 412 >4DY0-A nrPDB Length = 379 Score = 164 bits (415), Expect = 7e-41, Method: Compositional matrix adjust. Identities = 117/414 (28%), Positives = 199/414 (48%), Gaps = 48/414 (11%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 +E++ ++ G + +FN++ ++ NI SP I+S L + L A G T +++A V+ + Sbjct: 8 LEELGSNTG---IQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRY 64 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 + K++ A +N + AN + Sbjct: 65 -----------------------------GVNGVGKILKKINKAIVSKKNKDIVTVANAV 95 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 +V+ + ++ +K ++ E + VNF+ P + IN WV+ +T I NLLS D Sbjct: 96 FVKNASEIEVPFVTRNKDVFQCEVRNVNFED-PASACDSINAWVKNETRDMIDNLLSPDL 154 Query: 181 VKAT-TRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEK 239 + TRL+LVNA+YFK W+ +FQ E T + F + KS V M+ F Sbjct: 155 IDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSA 214 Query: 240 MN---FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETL 296 N + IELPY +SM I LP + +T L + ++ + + W +M Sbjct: 215 PNDLWYNFIELPYHGESISMLIALP---TESSTPLSAIIPHISTKTIDSWMS--IMVPKR 269 Query: 297 VDLHLPKFSLEDRIDLRDTLRNMGMTTAF-TTNADFRGM-TDKKDLAISKVIHQSFVAVD 354 V + LPKF+ + DL++ L+ +G+T F ++ A+F + T ++L +S ++ ++ + V Sbjct: 270 VQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVS 329 Query: 355 EKGTEAAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 E GT+A+AAT I+ +S F VD PF FFIRHN + +LF G+ P Sbjct: 330 EDGTKASAATTAILIARSS----PPWFIVDRPFLFFIRHNPTGAVLFMGQINKP 379 >5NCS-A nrPDB Length = 375 Score = 162 bits (410), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 120/397 (30%), Positives = 186/397 (46%), Gaps = 42/397 (10%) Query: 11 FTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSS 70 F DL + + N+F SP S+S AL +T A G TA EM L T Sbjct: 14 FAFDLLQTTRKHVTEANVFISPLSVSMALNMTLNGAAGVTADEMKTALRETGYTM----- 68 Query: 71 VARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLP 130 E+I+ L A K + ++ AN I+ ++ + Sbjct: 69 ---------------------EDINEYSHSLREALLKVDPSTTIGMANSIWYKQGELVKE 107 Query: 131 TYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILV 190 ++ ++ +Y AE + V+F + + IN W ++T KI +L D + + L+ Sbjct: 108 PFILANRTHYDAEVKAVDFSSP--ATLPAINGWCAQKTNDKITKIL--DYIPGNAFMYLI 163 Query: 191 NAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPYV 250 NA+YFK W +F+ T PFR + ++ V MM + TF E + +E+ Y Sbjct: 164 NAVYFKGIWVTQFKKSDTKRAPFRKADGTTQEVNMMAQKSTFGYTTDECCQY--LEMDYG 221 Query: 251 KRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWA-DSKMMTETLVDLHLPKFSLEDR 309 + SM ++LP++ + +EQL+ + W+ K + T V L +P+F E + Sbjct: 222 NKAFSMIVMLPNEGQTTRDVIEQLDNK-------HWSMIIKGIRPTQVSLRMPRFKTECK 274 Query: 310 IDL-RDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVII 368 L + L MGM FT ADF G+TD + IS+VIH++FV VDE+GTEAAA TAV + Sbjct: 275 YGLEKKILPEMGMNVPFTETADFPGITDAA-IFISRVIHKTFVQVDEEGTEAAAVTAVEM 333 Query: 369 SFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRF 405 T+S + F ++ PF F IR + ILF G Sbjct: 334 VKTSSPSTTPINFHINKPFVFAIREKSTGVILFIGEI 370 >4DTE-A nrPDB Length = 374 Score = 159 bits (401), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 107/408 (26%), Positives = 198/408 (48%), Gaps = 50/408 (12%) Query: 10 NFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESS 69 +F + +F + ++ D+N+ SP+ I+S L + + A G+T + +A + ++ Sbjct: 9 DFGLQVFAEAVQSAPDRNLALSPYGIASVLGMAQMGAYGATLKLLASKMGYS-------- 60 Query: 70 SVARPSRGRPKRRRM---DPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTY 126 RG PK +R+ D E + SG + V++ Sbjct: 61 ---LQERGMPKLQRLLQRDLASEDGVEVASG----------------------VMVDRKI 95 Query: 127 ALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTR 186 L + + K +++ P +++F + PE +R+ IN+W T+ I L S + TR Sbjct: 96 ILEKVFRRSLSKAFQSVPHQIDF-SQPEMARQVINSWTSDHTDGMISEFLPSGVLSELTR 154 Query: 187 LILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTF---PVLIMEKMNFK 243 L+ +NA++F W+ F T Q F + V MM F + + +++ Sbjct: 155 LVFLNALHFHGVWKTPFDPRNTREQLFHTVNGSAVSVPMMTTTQKFNYGEFVSKDGVDYD 214 Query: 244 MIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPK 303 +IE+PY +SM ++ P + KD L L +EL+ R+ +W + M + L +P+ Sbjct: 215 VIEMPYEGESISMLLVTPFE-KD--VPLSALNKELSSSRIHQW--RQEMRKISKQLSIPR 269 Query: 304 FSLEDRIDLRDTLRNMGMTTAFT-TNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAA 362 FS++ IDL+ TL MG+ F+ + ADF +T ++ L +SKV+ + + V+E+GT+ ++ Sbjct: 270 FSMDTEIDLKSTLSRMGLGDIFSQSRADFSRITTEEPLCVSKVLQRVKLEVNEEGTKGSS 329 Query: 363 ATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPVE 410 ATA +I ++ + + +D PF F I+H + +LF G+ P E Sbjct: 330 ATAAVI-YSRMAVEEI---TLDRPFFFLIQHKPTGALLFSGQLTQPQE 373 >4AJT-A nrPDB Length = 427 Score = 157 bits (398), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 116/409 (28%), Positives = 197/409 (48%), Gaps = 42/409 (10%) Query: 2 EQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFT 61 +Q+S +F +L K++ D N+ FSP+ +S A+ L KG T ++ L+ Sbjct: 56 QQLSNETSSFGFNLLRKIS-MRHDGNVIFSPFGLSVAMVNLMLGTKGETKVQIENGLNL- 113 Query: 62 EAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIY 121 +++ + P+ FK++ F+ R+ L + + Sbjct: 114 -QALSQAGPLILPAL---------------------FKKVKETFSSNRD-LGLSQGSFAF 150 Query: 122 VEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDV 181 + K + + TY LSKKY+ E +NF+ + Q+R IN + K+TE KI L D++ Sbjct: 151 IHKDFDIKETYFNLSKKYFDIEYVSINFQNS-SQARGLINHCIVKETEGKIPKLF--DEI 207 Query: 182 KATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMN 241 T+LILV+ + FK +W F T F L K ++ V MMY F +K Sbjct: 208 NPETKLILVDYVLFKGKWLTPFDPSFTEADTFHLDKYRAIKVPMMYREGNFTSTFDKKFR 267 Query: 242 FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHL 301 +++LPY + +M ++L + D LE LT + + W + M +++ Sbjct: 268 CHILKLPY-QGNATMLVVLMEKTGDYLA----LEDYLTVDLVETWLQN--MKTRKMEVFF 320 Query: 302 PKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTD-KKDLAISKVIHQSFVAVDEKGTEA 360 PKF L R ++ + L+ MG+ F+T+AD ++ ++L +S+V+ QS + VDE+GTEA Sbjct: 321 PKFKLNQRYEMHELLKQMGIRRLFSTSADLSELSAMARNLQVSRVLQQSVLEVDERGTEA 380 Query: 361 AAAT-AVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 + T + II+++ KV+ PFHF I S+ +LF GR P Sbjct: 381 VSGTLSEIIAYSMPP-----AIKVNRPFHFIIYEEMSRMLLFLGRVVNP 424 >2VDY-A nrPDB Length = 373 Score = 156 bits (394), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 120/401 (29%), Positives = 193/401 (48%), Gaps = 41/401 (10%) Query: 10 NFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESS 69 +F L+ L + KNIF SP SIS ALA+ L G T ++ + L F R+E+ Sbjct: 13 DFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSET- 71 Query: 70 SVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALL 129 IH GF+ L F K + + N ++++ + LL Sbjct: 72 -----------------------EIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELL 108 Query: 130 PTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLIL 189 ++ K YY++E +NF+ SR +IN++V+ +T+ KI +L S D A L+L Sbjct: 109 ESFSADIKHYYESEVLAMNFQDWATASR-QINSYVKNKTQGKIVDLFSGLDSPAI--LVL 165 Query: 190 VNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPY 249 VN I+FK W F T + F + + V MM T L ++ +++++ Y Sbjct: 166 VNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNY 225 Query: 250 VKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDR 309 V ++F +LPD K T + L R+ ++ W S +T + VDL++PK ++ Sbjct: 226 VGNG-TVFFILPDKGKMNTV-IAALSRD----TINRW--SAGLTSSQVDLYIPKVTISGV 277 Query: 310 IDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAV-II 368 DL D L MG+ FTT A+F +T L SKV+H++ + ++E+GTEAA A + I Sbjct: 278 YDLGDVLEEMGIADLFTTQANFSRITQDAQLKSSKVVHKAVLQLNEEGTEAAGAMFLEAI 337 Query: 369 SFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 + +I L+F + PF I + + + LF R PV Sbjct: 338 PRSKPII---LRF--NQPFIIMIFDHFTWSSLFLARVMNPV 373 >1JJO-C nrPDB Length = 261 Score = 154 bits (389), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 88/265 (33%), Positives = 147/265 (55%), Gaps = 13/265 (4%) Query: 109 RNNYSLRSANRIYVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQT 168 N Y ++ AN ++V+ + + +LQ+ K Y+ AE V+F + IN WVE T Sbjct: 1 ENQYVMKLANSLFVQNGFHVNEEFLQMLKMYFNAEVNHVDFSQNVAVANS-INKWVENYT 59 Query: 169 ESKIKNLLSSDDVKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYM 228 S +K+L+S +D T L L+NA+YFK W+ +F+ E T F + MMY Sbjct: 60 NSLLKDLVSPEDFDGVTNLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQ 119 Query: 229 RDTFPVLIMEKMN------FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYER 282 + F + ++++E+PY E+SM + L L LE L + Sbjct: 120 QGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLALSRQ----EVPLATLEPLLKAQL 175 Query: 283 LSEWADSKMMTETLVDLHLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAI 342 + EWA+S + + V+++LP+F++E IDL+D L+ +G+T F +A+ M+DKK+L + Sbjct: 176 IEEWANS--VKKQKVEVYLPRFTVEQEIDLKDILKALGVTEIFIKDANLTAMSDKKELFL 233 Query: 343 SKVIHQSFVAVDEKGTEAAAATAVI 367 SK +H+S + V+E+G+EAAAA+ +I Sbjct: 234 SKAVHKSCIEVNEEGSEAAAASGMI 258 >3ZHA-A nrPDB Length = 392 Score = 149 bits (377), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 107/401 (26%), Positives = 183/401 (45%), Gaps = 42/401 (10%) Query: 10 NFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESS 69 L+ + + +NI SP ++S+L L L K +TA + VL Sbjct: 15 GLAFSLYQAMAKDQAVENILLSPVVVASSLGLVSLGGKATTASQAKAVL----------- 63 Query: 70 SVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAF-NKPRNNYSLRSANRIYVEKTYAL 128 E + E +H+G ELL + N N + + +R+Y + + Sbjct: 64 ---------------SAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSF 108 Query: 129 LPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLI 188 +++ SK++Y E K+NF+ + + IN W + T+ K+ + + DV+ T + Sbjct: 109 AEDFVRSSKQHYNCEHSKINFRD-KRSALQSINEWAAQTTDGKLPEV--TKDVERTDGAL 165 Query: 189 LVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELP 248 LVNA++FK W+ KF + + F ++++ + V MM+ + EK +++E+P Sbjct: 166 LVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKLQIVEMP 225 Query: 249 YVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLED 308 + S+ IL+P ++ LE+LE+ LT E+L W M + V + LPK +E Sbjct: 226 LAHKLSSLIILMPHHVEP----LERLEKLLTKEQLKIWMGK--MQKKAVAISLPKGVVEV 279 Query: 309 RIDLRDTLRNMGMTTAFTTN-ADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVI 367 DL+ L +G+T A N AD M+ KKDL ++ V H + D +G Sbjct: 280 THDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFEWDTEGNPFDQDI--- 336 Query: 368 ISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 + + F DHPF F +R +S ++LF GR P Sbjct: 337 --YGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRP 375 >1C8O-A nrPDB Length = 300 Score = 148 bits (373), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 106/365 (29%), Positives = 183/365 (50%), Gaps = 75/365 (20%) Query: 13 VDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSSVA 72 +D+F ++ + + +N+F SP SISS L + Y A GSTA ++++ + Sbjct: 1 MDIFREIASSMKGENVFISPPSISSVLTILYYGANGSTAEQLSKYV-------------- 46 Query: 73 RPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTY 132 E E +N +++ S +S N++Y + ++ Sbjct: 47 --------------EKEADKN---------------KDDISFKSMNKVYGRYSAVFKDSF 77 Query: 133 LQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILVNA 192 L+ + Q V+F + ++ IN V+ TE KI LL + + T L+ ++A Sbjct: 78 LRKIGDNF----QTVDFTDS--RTVDAINKSVDIFTEGKINPLLD-EPLSPDTSLLAISA 130 Query: 193 IYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYM----------RDTFPVLIMEKMNF 242 +YFKA+W + F+ E TS PF +S + V MM M +++F NF Sbjct: 131 VYFKAKWLMPFEKEFTSDYPFYVSPTEMVDVSMMSMYGEAFNHASVKESFG-------NF 183 Query: 243 KMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLP 302 +IELPYV + SM ++LPD+I GLE +E+ LT +W+DS M +D+H+P Sbjct: 184 SIIELPYVG-DTSMVVILPDNID----GLESIEQNLTDTNFKKWSDS--MDAMFIDVHIP 236 Query: 303 KFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAA 362 KF + +L D L +G+T F + D+ M++ D+++ +IH++++ V+E+ TEAAA Sbjct: 237 KFKVTGSYNLVDALVKLGLTEVFGSTGDYSNMSN-SDVSVDAMIHKTYIDVNEEYTEAAA 295 Query: 363 ATAVI 367 AT+ + Sbjct: 296 ATSAL 300 >1SEK-A nrPDB Length = 378 Score = 143 bits (361), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 124/406 (30%), Positives = 200/406 (49%), Gaps = 53/406 (13%) Query: 11 FTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVL-----HFTEAVR 65 FT +F+++ + N +N+ S +S+ L LA+ G + E+ L + T+ V Sbjct: 18 FTAQMFSEVVKANPGQNVVLSAFSVLPPLGQLALASVGESHDELLRALALPNDNVTKDVF 77 Query: 66 AESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKT 125 A+ + R +G L+ A++IYV K Sbjct: 78 ADLNRGVRAVKG----------------------------------VDLKMASKIYVAKG 103 Query: 126 YALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATT 185 L + +S+ + +E Q V+F + E + IN WVE QT ++IKNL+ D + TT Sbjct: 104 LELNDDFAAVSRDVFGSEVQNVDFVKSVEAA-GAINKWVEDQTNNRIKNLVDPDALDETT 162 Query: 186 RLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMI 245 R +LVNAIYFK W+ KF E+T + F +SK+K+ V M + + +++ KMI Sbjct: 163 RSVLVNAIYFKGSWKDKFNKERTMDRDFHVSKDKTIKVPTMIGKKDVRYADVPELDAKMI 222 Query: 246 ELPYVKRELSMFILLPDDIKDGTTGLEQ-LERELTYERLSEWADSKMMTETLVDLHLPKF 304 E+ Y + SM I+LP+ + DG T LEQ L+ R E + T V+++LPKF Sbjct: 223 EMSYEGDQASMIIILPNQV-DGITALEQKLKDPKALSRAEE-----RLYNTEVEIYLPKF 276 Query: 305 SLEDRIDLRDTLRNMGMTTAFTTNADF--RGMTDKKDLAISKVIHQSFVAVDEKGTEAAA 362 +E DL++ L NM + FT A + K+ L + I ++F+ V+E+G EAAA Sbjct: 277 KIETTTDLKEVLSNMNIKKLFTPGAARLENLLKTKESLYVDAAIQKAFIEVNEEGAEAAA 336 Query: 363 ATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 A A I TT + V K +++ PF F +++N++ +F G P Sbjct: 337 ANAFKI--TTYSFHFVPKVEINKPFFFSLKYNRNS--MFSGVCVQP 378 >5NCU-A nrPDB Length = 336 Score = 143 bits (360), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 108/358 (30%), Positives = 168/358 (46%), Gaps = 42/358 (11%) Query: 11 FTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSS 70 F DL + + N+F SP S+S AL +T A G TA EM L T Sbjct: 14 FAFDLLQTTRKHVTEANVFISPLSVSMALNMTLNGAAGVTADEMKTALRETGYTM----- 68 Query: 71 VARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLP 130 E+I+ L A K + ++ AN I+ ++ + Sbjct: 69 ---------------------EDINEYSHSLREALLKVDPSTTIGMANSIWYKQGELVKE 107 Query: 131 TYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILV 190 ++ ++ +Y AE + V+F + + IN W ++T KI +L D + + L+ Sbjct: 108 PFILANRTHYDAEVKAVDFSSP--ATLPAINGWCAQKTNDKITKIL--DYIPGNAFMYLI 163 Query: 191 NAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPYV 250 NA+YFK W +F+ T PFR + ++ V MM + TF E + +E+ Y Sbjct: 164 NAVYFKGIWVTQFKKSDTKRAPFRKADGTTQEVNMMAQKSTFGYTTDECCQY--LEMDYG 221 Query: 251 KRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWA-DSKMMTETLVDLHLPKFSLEDR 309 + SM ++LP++ + +EQL+ + W+ K + T V L +P+F E + Sbjct: 222 NKAFSMIVMLPNEGQTTRDVIEQLDNK-------HWSMIIKGIRPTQVSLRMPRFKTECK 274 Query: 310 IDL-RDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAV 366 L + L MGM FT ADF G+TD + IS+VIH++FV VDE+GTEAAA TAV Sbjct: 275 YGLEKKILPEMGMNVPFTETADFPGITDAA-IFISRVIHKTFVQVDEEGTEAAAVTAV 331 >3LE2-A nrPDB Length = 393 Score = 142 bits (357), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 103/410 (25%), Positives = 174/410 (42%), Gaps = 66/410 (16%) Query: 22 TNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSSVARPSRGRPKR 81 +++ N+ FSP SI+ L++ + G+T ++ L F+ Sbjct: 27 VSQNSNVIFSPASINVVLSIIAAGSAGATKDQILSFLKFSST------------------ 68 Query: 82 RRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTYLQLSKKYYK 141 +Q + S + A L AN +++K+ + P++ QL + YK Sbjct: 69 -------DQLNSFSSEIVSAVLADGSANGGPKLSVANGAWIDKSLSFKPSFKQLLEDSYK 121 Query: 142 AEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILVNAIYFKAEWEV 201 A + +F++ + E+N+W EK+T I +L + T+LI NA+YFK W Sbjct: 122 AASNQADFQSKAVEVIAEVNSWAEKETNGLITEVLPEGSADSMTKLIFANALYFKGTWNE 181 Query: 202 KFQAEKTSIQPFR-LSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPYV----KRELSM 256 KF T F L NK V +M + FK++ LPY+ KR+ SM Sbjct: 182 KFDESLTQEGEFHLLDGNK---VTAPFMTSKKKQYVSAYDGFKVLGLPYLQGQDKRQFSM 238 Query: 257 FILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH------------LPKF 304 + LPD LS+ D + T +D H +PKF Sbjct: 239 YFYLPD----------------ANNGLSDLLDKIVSTPGFLDNHIPRRQVKVREFKIPKF 282 Query: 305 SLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDK----KDLAISKVIHQSFVAVDEKGTEA 360 D + L+ +G+T+ F+ M + K+L +S + H++ + V+E+GTEA Sbjct: 283 KFSFGFDASNVLKGLGLTSPFSGEEGLTEMVESPEMGKNLCVSNIFHKACIEVNEEGTEA 342 Query: 361 AAATAVIISFTTSVINH-VLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 AAA+A +I ++ + F DHPF + N + +LF G+ P+ Sbjct: 343 AAASAGVIKLRGLLMEEDEIDFVADHPFLLVVTENITGVVLFIGQVVDPL 392 >2R9Y-A nrPDB Length = 430 Score = 141 bits (356), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 111/400 (27%), Positives = 191/400 (47%), Gaps = 54/400 (13%) Query: 11 FTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSS 70 FT DLF+ + +T+ N+ SP S++ AL+ L A+ T + VLH Sbjct: 28 FTTDLFSLVAQTSTSSNLVLSPLSVALALSHLALGAQNQTLHSLHRVLHM---------- 77 Query: 71 VARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLP 130 N S LL+ F + ++R A RIY++K + + Sbjct: 78 ----------------------NTGSCLPHLLSHFYQNLGPGTIRLAARIYLQKGFPIKD 115 Query: 131 TYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILV 190 +L+ S++ + A+P K+ K E+ IN WV++ TE KI++ LS ++ +T L+L+ Sbjct: 116 DFLEQSERLFGAKPVKLTGKQ--EEDLANINQWVKEATEGKIEDFLS--ELPDSTVLLLL 171 Query: 191 NAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPV--LIMEKMNFKMIELP 248 NAI+F W KF T F L + + V MM+ ++P+ ++E+ ++ P Sbjct: 172 NAIHFHGFWRTKFDPSLTQKDFFHLDERFTVSVDMMHAV-SYPLRWFLLEQPEIQVAHFP 230 Query: 249 YVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLED 308 + K +S +++P + + ++ LT++ L + E + LPK L+ Sbjct: 231 F-KNNMSFVVVMPTYFE---WNVSEVLANLTWDTLYH----PSLQERPTKVWLPKLHLQQ 282 Query: 309 RIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVII 368 ++DL TL +G+ F D RG++++ +L +S V HQS + + E G EAAAAT+V + Sbjct: 283 QLDLVATLSQLGLQELFQ-GPDLRGISEQ-NLVVSSVQHQSTMELSEAGVEAAAATSVAM 340 Query: 369 SFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 + + + F V+ PF FFI + LF G P Sbjct: 341 NRMS-----LSSFTVNRPFLFFIMEDTIGVPLFVGSVRNP 375 >5INW-A nrPDB Length = 421 Score = 140 bits (353), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 104/368 (28%), Positives = 175/368 (47%), Gaps = 31/368 (8%) Query: 2 EQVSASIGNFTVDLFNK-LNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 +++++++ L+ + L NIFFSP SI+SAL + A GST E+ L F Sbjct: 79 QRIASAVNGLGFRLYKQVLGGAGPADNIFFSPLSIASALGVVTAGANGSTRAELDTALGF 138 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 E + G+ K + M F L A K + L N + Sbjct: 139 KEFLH-----------GKKKAKSMKY-----------FARLNGALYKRSAGFELMGKNVV 176 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 + +K L + + +K+ + V+F + + + + +N ++EK T K +++S D Sbjct: 177 FSKKGLWLYRQFTRTVAHLFKSNVRSVDFGDS-KNAVELMNAYIEKVTSKKFPDVIS--D 233 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 V T L++VN IYFK W KF+ + T F ++ + S V M+ R K+ Sbjct: 234 VDTDTSLVIVNVIYFKGSWGNKFEPDLTKNVRFWVNSSYSMMVPTMHQRAKLSYTQDRKL 293 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 +++LPY + SM +++P +D L ++E ++ E+L EW + V L Sbjct: 294 RSTVVKLPY-EGGASMLVIVPHRTED----LPKVEESVSQEQLEEWLSLLGPSNHYVQLS 348 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEA 360 LPKF + DL+ L MGM++ F+ AD +T + L + K+ H+S + V+E+GTEA Sbjct: 349 LPKFKISVSYDLKAYLSAMGMSSMFSYGADLSRITGMQKLHVDKITHKSVLHVNEEGTEA 408 Query: 361 AAATAVII 368 A T V I Sbjct: 409 KAETVVGI 416 >6F02-A nrPDB Length = 389 Score = 135 bits (340), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 120/419 (28%), Positives = 200/419 (47%), Gaps = 53/419 (12%) Query: 3 QVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTE 62 +++ + +F + + KNIFFSP SIS+A A+ L A + ++ E L F Sbjct: 6 KIAPANADFAFRFYYLIASETPGKNIFFSPLSISAAYAMLSLGACSHSRSQILEGLGFNL 65 Query: 63 AVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYV 122 +ES ++H GF+ LL N P + R + +++ Sbjct: 66 TELSES------------------------DVHRGFQHLLHTLNLPGHGLETRVGSALFL 101 Query: 123 EKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVK 182 L +L + Y+A+ NF + + IN V+K+T KI +L+S ++K Sbjct: 102 SHNLKFLAKFLNDTMAVYEAKLFHTNFYDT-VGTIQLINDHVKKETRGKIVDLVS--ELK 158 Query: 183 ATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMM--------YMRDTFPV 234 ++LVN IYFKA WE F + +T+ + F + +N + V MM Y+ D + Sbjct: 159 KDVLMVLVNYIYFKALWEKPFISSRTTPKDFYVDENTTVRVPMMLQDQEHHWYLHDRYLP 218 Query: 235 LIMEKMNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWAD--SKMM 292 + +M++ K + ++F +LP+ K + ++E LT E L W + K Sbjct: 219 CSVLRMDY--------KGDATVFFILPNQGK-----MREIEEVLTPEMLMRWNNLLRKRN 265 Query: 293 TETLVDLHLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVA 352 ++LHLPKFS+ L L +G T F+ AD G+T ++ L SK H++ + Sbjct: 266 FYKKLELHLPKFSISGSYVLDQILPRLGFTDLFSKWADLSGITKQQKLEASKSFHKATLD 325 Query: 353 VDEKGTEAAAATAVIISFTTSVIN-HVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPVE 410 VDE GTEAAAAT+ I F ++ N H+L+F + PF I ++++LF G+ P + Sbjct: 326 VDEAGTEAAAATSFAIKFFSAQTNRHILRF--NRPFLVVIFSTSTQSVLFLGKVVDPTK 382 >6CJ7-A nrPDB Length = 390 Score = 134 bits (338), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 103/400 (25%), Positives = 187/400 (46%), Gaps = 41/400 (10%) Query: 11 FTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSS 70 F V++F ++ T + N+ SP+SI+ LA+ A G+T E+ L T AE Sbjct: 20 FGVNVFKQM-ATEQSGNLAASPFSITILLAMLQQGAAGNTLDEITRALQMTPEKSAEI-- 76 Query: 71 VARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLP 130 FK++ K + L++AN +++ + + L P Sbjct: 77 ---------------------------FKKVNEEIQKRNSRNILKTANNVFLSENFNLNP 109 Query: 131 TYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILV 190 + +++ + ++ F P + + IN+W+ +T KI L+S DD+ T++++V Sbjct: 110 QFKRIAVNNFDSDLTPTYFGK-PALAAQNINSWIASKTNDKIDKLVSPDDLSGNTQMVMV 168 Query: 191 NAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPYV 250 NA+YFK WE+ F+ + T + F L+ + K M R F + K++ LP+ Sbjct: 169 NAVYFKGLWEIPFREQATQKRNFTLNGGEKKVASFMQTRRYFKAGTHKPAMAKVVVLPFE 228 Query: 251 KRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDRI 310 E S+ ++LP +K ++ ++ L L+ E ++ + D + V L LPKFS++ I Sbjct: 229 YNEYSLIVVLP--LK--SSNVDALLSSLSMEDVASFLD---LPPKDVALELPKFSIKADI 281 Query: 311 DLRDTLRNMGMTTAFTTNADFRGMTDKKDLA--ISKVIHQSFVAVDEKGTEAAAATAVII 368 +L L MG+++ FT A+ + L+ +S +H + + +DE+G +AAA Sbjct: 282 NLEPVLNKMGVSSIFTQQAELYNLGSHGSLSPQVSSALHSAVLTIDERGG-SAAAATSFA 340 Query: 369 SFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 + S L F+ + PF + N+S LF R P Sbjct: 341 AVALSYDEPSLYFRANKPFLAILWDNRSSIPLFMARIMDP 380 >1K9O-I nrPDB Length = 378 Score = 134 bits (336), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 103/349 (29%), Positives = 166/349 (47%), Gaps = 49/349 (14%) Query: 11 FTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVL-----HFTEAVR 65 FT +F+++ + N +N+ S +S+ L LA+ G + E+ L + T+ V Sbjct: 18 FTAQMFSEVVKANPGQNVVLSAFSVLPPLGQLALASVGESHDELLRALALPNDNVTKDVF 77 Query: 66 AESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKT 125 A+ + R +G L+ A++IYV K Sbjct: 78 ADLNRGVRAVKG----------------------------------VDLKMASKIYVAKG 103 Query: 126 YALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATT 185 L + +S+ + +E Q V+F + E + IN WVE QT ++IKNL+ D + TT Sbjct: 104 LELNDDFAAVSRDVFGSEVQNVDFVKSVEAA-GAINKWVEDQTNNRIKNLVDPDALDETT 162 Query: 186 RLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMI 245 R +LVNAIYFK W+ KF E+T + F +SK+K+ V M + + +++ KMI Sbjct: 163 RSVLVNAIYFKGSWKDKFVKERTMDRDFHVSKDKTIKVPTMIGKKDVRYADVPELDAKMI 222 Query: 246 ELPYVKRELSMFILLPDDIKDGTTGLEQ-LERELTYERLSEWADSKMMTETLVDLHLPKF 304 E+ Y + SM I+LP+ + DG T LEQ L+ R E + T V++ LPKF Sbjct: 223 EMSYEGDQASMIIILPNQV-DGITALEQKLKDPKALSRAEE-----RLYNTEVEITLPKF 276 Query: 305 SLEDRIDLRDTLRNMGMTTAFTTNADF--RGMTDKKDLAISKVIHQSFV 351 +E DL++ L NM + FT A + K+ L + I ++F+ Sbjct: 277 KIETTTDLKEVLSNMNIKKLFTPGAARLENLLKTKESLTVDAAIQKAFI 325 >3PZF-A nrPDB Length = 397 Score = 133 bits (335), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 97/393 (24%), Positives = 183/393 (46%), Gaps = 38/393 (9%) Query: 23 NRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSSVARPSRGRPKRR 82 N + N+ SP+S+ L L Y A+ S ++ + E SSV Sbjct: 36 NHNSNVVLSPFSVKILLTLIYEASDTSFGNAVSNT-------KRELSSVI---------- 78 Query: 83 RMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTYLQLSKKYYKA 142 +++ ++ S +K+LL + + +Y L A +V+ ++ Y Q++ +Y A Sbjct: 79 ----QNDNIDHTRSYYKQLLESAQQDNKDYDLNIATNFFVDDFIEVINKYQQIANTHYHA 134 Query: 143 EPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILVNAIYFKAEWEVK 202 +KV++ + P Q+ IN WV + T +++ +++ D ++ + LVN IYFK W Sbjct: 135 MLEKVSY-SNPTQTAATINNWVSEHTNGRLREIVTPDSLEGAV-ITLVNVIYFKGLWTYP 192 Query: 203 FQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPYVKRELSMFILLPD 262 F +++PF ++ K + M F + +++ LPY +L+M+ +LP+ Sbjct: 193 FPEVANNVKPFYGTRGKPTNAQYMEQNGQFYYDNSADLGAQILRLPYRGNKLAMYFILPN 252 Query: 263 DIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDRIDLRDTLRNMGMT 322 L+++ ++ L W M E V++ LPKF + L + L+ +G+ Sbjct: 253 PDNTVNQVLDRINSASLHQAL--W----YMEENEVNVTLPKFKFDFSEQLNEPLQQVGIR 306 Query: 323 TAFTTNADF----RGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAV--IISFTTSVIN 376 F+ NA RG + ++ +S++ ++ + ++E G+EA AAT + + F + Sbjct: 307 EIFSQNASLPLLARGRGARDEVRVSRIFQKAGITINELGSEAYAATEIQLVNKFGG---D 363 Query: 377 HVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 V F + PF FFI T+LF G+ PV Sbjct: 364 GVQIFNANRPFIFFIEDETLGTMLFAGKIENPV 396 >4AJU-A nrPDB Length = 387 Score = 132 bits (332), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 98/364 (26%), Positives = 174/364 (47%), Gaps = 38/364 (10%) Query: 2 EQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFT 61 +Q++ NF L K++ D N+ FSP+ +S A+ L A G T ++ LH Sbjct: 52 QQLAKETSNFGFSLLRKIS-MRHDGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQ 110 Query: 62 EAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRN-NYSLRSANRI 120 +P + + P ++ G +E L+ RN L + Sbjct: 111 AL--------------KPTKPGLLP------SLFKGLRETLS-----RNLELGLTQGSFA 145 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 ++ K + + T+ LSK+Y+ E +NF+ A Q+++ +N ++ K+T KI L D+ Sbjct: 146 FIHKDFDVKETFFNLSKRYFDTECVPMNFRNA-SQAKRLMNHYINKETRGKIPKLF--DE 202 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 + T+LILV+ I FK +W F T + F L K K+ V MMY F + Sbjct: 203 INPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNF 262 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 +++LPY + +M ++L + + D LE LT + + W + M +++ Sbjct: 263 RCHVLKLPY-QGNATMLVVLMEKMGDHLA----LEDYLTTDLVETWL--RNMKTRNMEVF 315 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMT-DKKDLAISKVIHQSFVAVDEKGTE 359 PKF L+ + ++ + LR MG+ F+ AD ++ ++L +S+V+ ++ + VDE+GTE Sbjct: 316 FPKFKLDQKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTE 375 Query: 360 AAAA 363 A A Sbjct: 376 AVAG 379 >1M93-B nrPDB Length = 245 Score = 130 bits (328), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 86/265 (32%), Positives = 145/265 (54%), Gaps = 32/265 (12%) Query: 113 SLRSANRIYVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKI 172 S +S N++Y + ++L+ + Q V+F + ++ IN V+ TE KI Sbjct: 3 SFKSMNKVYGRYSAVFKDSFLRKIGDNF----QTVDFTDS--RTVDAINKSVDIFTEGKI 56 Query: 173 KNLLSSDDVKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYM---- 228 LL + + T L+ ++A+YFKA+W + F+ E TS PF +S + V MM M Sbjct: 57 NPLLD-EPLSPDTSLLAISAVYFKAKWLMPFEKEFTSDYPFYVSPTEMVDVSMMSMYGEA 115 Query: 229 ------RDTFPVLIMEKMNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYER 282 +++F NF +IELPYV + SM ++LPD+I GLE +E+ LT Sbjct: 116 FNHASVKESFG-------NFSIIELPYVG-DTSMVVILPDNID----GLESIEQNLTDTN 163 Query: 283 LSEWADSKMMTETLVDLHLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAI 342 +W+DS M +D+H+PKF + +L D L +G+T F + D+ M++ D+++ Sbjct: 164 FKKWSDS--MDAMFIDVHIPKFKVTGSYNLVDALVKLGLTEVFGSTGDYSNMSN-SDVSV 220 Query: 343 SKVIHQSFVAVDEKGTEAAAATAVI 367 +IH++++ V+E+ TEAAAAT+ + Sbjct: 221 DAMIHKTYIDVNEEYTEAAAATSAL 245 >2V95-A nrPDB Length = 371 Score = 121 bits (303), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 107/407 (26%), Positives = 186/407 (45%), Gaps = 73/407 (17%) Query: 10 NFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF--TEAVRAE 67 +F +L+ +L N DKN SP SIS ALA+ L GS + + L F TE AE Sbjct: 15 DFAFNLYQRLVALNPDKNTLISPVSISMALAMVSL---GSAQTQSLQSLGFNLTETSEAE 71 Query: 68 SSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYA 127 IH F+ L + + N +++ + Sbjct: 72 --------------------------IHQSFQYLNYLLKQSDTGLEMNMGNAMFLLQKLK 105 Query: 128 LLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRL 187 L ++L K+YY++E ++F+ + S+ +IN V+ +T+ KI+++ S D+ + Sbjct: 106 LKDSFLADVKQYYESEALAIDFEDWTKASQ-QINQHVKDKTQGKIEHVFS--DLDSPASF 162 Query: 188 ILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMM-------YMRDT-FPVLIMEK 239 ILVN I+ + WE+ F E T + F +++ + V MM Y RD+ FP Sbjct: 163 ILVNYIFLRGIWELPFSPENTREEDFYVNETSTVKVPMMVQSGSIGYFRDSVFPC----- 217 Query: 240 MNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDL 299 ++I++ YV + FIL PD + ++ + L+ + + W K+MT V+L Sbjct: 218 ---QLIQMDYVGNGTAFFIL-PDQGQ-----MDTVIAALSRDTIDRWG--KLMTPRQVNL 266 Query: 300 HLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTE 359 ++PKFS+ D DL+D L ++ + T +DF G T L ++ ++H++ + +DE Sbjct: 267 YIPKFSMSDTYDLKDVLEDLNIKDLLTNQSDFSGNTKDVPLTLT-MVHKAMLQLDEGN-- 323 Query: 360 AAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFC 406 V+ + T H+ +D I+ NK +L F +F Sbjct: 324 ------VLPNSTNGAPLHLRSEPLD------IKFNKPFILLLFDKFT 358 >6F4U-A nrPDB Length = 341 Score = 120 bits (302), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 109/378 (28%), Positives = 178/378 (47%), Gaps = 50/378 (13%) Query: 3 QVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTE 62 +++ + +F + + KNIFFSP SIS+A A+ L A + ++ E L F Sbjct: 4 KIAPANADFAFRFYYLIASETPGKNIFFSPLSISAAYAMLSLGACSHSRSQILEGLGFNL 63 Query: 63 AVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYV 122 +ES ++H GF+ LL N P + R + +++ Sbjct: 64 TELSES------------------------DVHRGFQHLLHTLNLPGHGLETRVGSALFL 99 Query: 123 EKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVK 182 L +L + Y+A+ NF + + IN V+K+T KI +L+S ++K Sbjct: 100 SHNLKFLAKFLNDTMAVYEAKLFHTNFYDTV-GTIQLINDHVKKETRGKIVDLVS--ELK 156 Query: 183 ATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMM--------YMRDTFPV 234 ++LVN IYFKA WE F + +T+ + F + +N + V MM Y+ D + Sbjct: 157 KDVLMVLVNYIYFKALWEKPFISSRTTPKDFYVDENTTVRVPMMLQDQEHHWYLHDRYLP 216 Query: 235 LIMEKMNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWAD--SKMM 292 + +M++ K + ++F +LP+ K + ++E LT E L W + K Sbjct: 217 CSVLRMDY--------KGDATVFFILPNQGK-----MREIEEVLTPEMLMRWNNLLRKRN 263 Query: 293 TETLVDLHLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVA 352 ++LHLPKFS+ L L +G T F+ AD G+T ++ L SK H++ + Sbjct: 264 FYKKLELHLPKFSISGSYVLDQILPRLGFTDLFSKWADLSGITKQQKLEASKSFHKATLD 323 Query: 353 VDEKGTEAAAATAVIISF 370 VDE GTEAAAAT+ I F Sbjct: 324 VDEAGTEAAAATSFAIKF 341 >6BJ5-B nrPDB Length = 315 Score = 115 bits (287), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 89/347 (25%), Positives = 161/347 (46%), Gaps = 63/347 (18%) Query: 23 NRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSSVARPSRGRPKRR 82 N N+ FSP+ ++SAL++ +AA G+T RE + E+V +S + Sbjct: 28 NESDNVVFSPYGLTSALSVLRIAAGGNTKRE----IDVPESVVEDSDAFL---------- 73 Query: 83 RMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTYLQLSKKYYKA 142 +EL +V+ + L P + + Sbjct: 74 --------------ALREL-------------------FVDASVPLRPEFTAEFSSRFNT 100 Query: 143 EPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILVNAIYFKAEWEVK 202 Q+V F + E + IN++V+ +T + +L + + T+++L++++ K W Sbjct: 101 SVQRVTFNS--ENVKDVINSYVKDKTGGDVPRVLDAS-LDRDTKMLLLSSVRMKTSWRHV 157 Query: 203 FQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPV--LIMEKMNFKMIELPYVKRELSMFILL 260 F T+ QPF S N + V+MM DT + + + + ELPY +R+ +M +++ Sbjct: 158 FDPSFTTDQPF-YSGNVTYKVRMMNKIDTLKTETFTLRNVGYSVTELPYKRRQTAMLLVV 216 Query: 261 PDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDRIDLRDTLRNMG 320 PDD L ++ R L + W + M + + + +PKFS+E +DLRD L+ +G Sbjct: 217 PDD-------LGEIVRALDLSLVRFWI--RNMRKDVCQVVMPKFSVESVLDLRDALQRLG 267 Query: 321 MTTAFT-TNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAV 366 + AF + ADF + DL ++KV+ S + DE+GT A++ TA+ Sbjct: 268 VRDAFDPSRADFGQASPSNDLYVTKVLQTSKIEADERGTTASSDTAI 314 >2PEF-A nrPDB Length = 373 Score = 114 bits (286), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 110/400 (27%), Positives = 187/400 (46%), Gaps = 51/400 (12%) Query: 9 GNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAES 68 +F+++LF N + +N SP S ALA+T A T +M + L + Sbjct: 14 ADFSIELFK--NSIDDKENSLISPLSAMLALAMTANGADNETLAQMEKAL-------GKD 64 Query: 69 SSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYAL 128 S+ ++ + P E+++ L AN I+ ++ Sbjct: 65 ISIEDLNKYLYTYMKKLPNEEKSK---------------------LTIANSIWFKEN-DF 102 Query: 129 LPT--YLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTR 186 +P+ +LQ+ YYKA+ K F ++ + +IN WV+ +T I +L+ D + Sbjct: 103 MPSKDFLQIIADYYKADIFKAAFDSS---TVSDINNWVKSKTNGMIDKILNKIDPEDV-- 157 Query: 187 LILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIE 246 + L+NA+ F AEWE + EK S+ + K+ +M + I E+ ++ Sbjct: 158 MYLINAVAFDAEWETVY--EKASVHEDIFTDVYGNRQKVEFMNSEENLYIEEENAVGFVK 215 Query: 247 LPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSL 306 PY K S +LPD+ + + + LT ++ + + +T LV LPKF Sbjct: 216 -PYAKNHYSFVAILPDE----NISVNEYIKTLTGQKFIDLIKNAKIT--LVRASLPKFKY 268 Query: 307 EDRIDLRDTLRNMGMTTAFTTN-ADFR--GMTDKKDLAISKVIHQSFVAVDEKGTEAAAA 363 E I + +TL ++GMT AF + ADF G +D +L IS+V+H++F++VDE GT+A A Sbjct: 269 EYTIKMNETLESLGMTDAFLPDKADFSKLGKSDIGNLYISEVLHKTFISVDELGTKAGAV 328 Query: 364 TAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFG 403 T+V I+ +N K++ PF F I N + +F G Sbjct: 329 TSVDITAAGIPVNFK-TVKLNRPFIFAIIDNSTNLPIFIG 367 >1IMV-A nrPDB Length = 398 Score = 111 bits (278), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 100/411 (24%), Positives = 190/411 (46%), Gaps = 49/411 (11%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 + +++A++ NF DL+ + + N+ SP S+++AL+ L A T + L++ Sbjct: 31 VNKLAAAVSNFGYDLYRVRSSMSPTTNVLLSPLSVATALSALSLGADERTESIIHRALYY 90 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 ++ P +IH +KELL P+ N L+SA+RI Sbjct: 91 --------DLISSP------------------DIHGTYKELLDTVTAPQKN--LKSASRI 122 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 EK + +++ +K Y P+ + P +EIN WV+ Q + K+ S+ + Sbjct: 123 VFEKKLRIKSSFVAPLEKSYGTRPRVLTGN--PRLDLQEINNWVQAQMKGKLAR--STKE 178 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVL---IM 237 + ++L+ +FK +W KF + KTS++ F L + ++ V++ M D VL + Sbjct: 179 IPDEISILLLGVAHFKGQWVTKFDSRKTSLEDFYLDEERT--VRVPMMSDPKAVLRYGLD 236 Query: 238 EKMNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLV 297 ++ K+ +LP + +S+ LP + T L +E LT E + + D ++ T V Sbjct: 237 SDLSCKIAQLP-LTGSMSIIFFLPLKV---TQNLTLIEESLTSEFIHD-IDRELKTVQAV 291 Query: 298 DLHLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKG 357 L +PK L ++ +L+ M + + F + DF +T K + +++V H++ +E G Sbjct: 292 -LTVPKLKLSYEGEVTKSLQEMKLQSLFDS-PDFSKITGKP-IKLTQVEHRAGFEWNEDG 348 Query: 358 TEAAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 A T + + L + ++ PF F +R + +LF G+ P Sbjct: 349 ----AGTTPSPGLQPAHLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDP 395 >3STO-A nrPDB Length = 406 Score = 107 bits (268), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 81/297 (27%), Positives = 142/297 (47%), Gaps = 9/297 (3%) Query: 114 LRSANRIYVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIK 173 +R + I+VEKTY + + + + E ++V+F + +IN WV++Q+ ++ Sbjct: 115 VRISTGIFVEKTYEVERRFNESIANDSEGELKQVDFSNR-TSATVDINDWVDQQSNGLLE 173 Query: 174 NLLSSDDVKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFP 233 + DD+ T +ILVN YF+ W+ F+ T + F +S ++ V MM Sbjct: 174 KFFT-DDIPDDTAMILVNVFYFRDFWQSPFEPHYTRKEDFYISPDRQITVDMMTQEGVMK 232 Query: 234 VLIMEKMNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMT 293 E F+++ P + I+LP + E L + LSE+ K + Sbjct: 233 YGKFEDEGFEIVSKPLNNTRFTFVIVLPLEKWSLNGATELLNGN---KVLSEYV--KNLK 287 Query: 294 ETLVDLHLPKFSLEDRIDLRDTLRNMGMTTAF-TTNADFRGMTDKKDLAISKVIHQSFVA 352 ET V L LPKF+L++ +DL TL+++G+ F +D G+T +L +++ I + + Sbjct: 288 ETTVSLRLPKFTLKNTLDLVPTLKSIGVVDLFDPVKSDLSGITPNPNLYVNEFIQTNVLK 347 Query: 353 VDEKGTEAAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 ++E G EA T+ I +++I V F V HPF FI + + + PV Sbjct: 348 LNESGIEATTVTSPIFVPFSAIIPEV-DFHVTHPFICFIYDQQLTMPIMAAKVMNPV 403 >2OAY-A nrPDB Length = 390 Score = 107 bits (267), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 104/405 (25%), Positives = 189/405 (46%), Gaps = 54/405 (13%) Query: 7 SIGNFTVDLFNKLNETNR-DKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVR 65 ++ +F++ L++ + + + N+ FSP+SI+S L L A +T + +L + + Sbjct: 35 ALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDFT 94 Query: 66 AESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKT 125 +H K T + S ++I+ Sbjct: 95 C---------------------------VHQALKGFTTK--------GVTSVSQIFHSPD 119 Query: 126 YALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATT 185 A+ T++ S+ Y + P+ ++ + + + + INTWV K T +KI LL D + + T Sbjct: 120 LAIRDTFVNASRTLYSSSPRVLSNNS--DANLELINTWVAKNTNNKISRLL--DSLPSDT 175 Query: 186 RLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPV--LIMEKMNFK 243 RL+L+NAIY A+W+ F +KT ++PF KN V MM + +PV I + + K Sbjct: 176 RLVLLNAIYLSAKWKTTFDPKKTRMEPFHF-KNSVIKVPMMNSKK-YPVAHFIDQTLKAK 233 Query: 244 MIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPK 303 + +L + LS+ IL+P ++K +EQ ++ + E + TL L LP+ Sbjct: 234 VGQL-QLSHNLSLVILVPQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTL--LTLPR 290 Query: 304 FSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAA 363 + D+ + + F+ + + G+T+ DL +S + HQ+ + + E G EAAAA Sbjct: 291 IKVTTSQDMLSIMEKLEFFD-FSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAA 349 Query: 364 TAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 +A+ ++ T +L F+V PF F + + K +F GR P Sbjct: 350 SAISVART------LLVFEVQQPFLFMLWDQQHKFPVFMGRVYDP 388 >1SNG-A nrPDB Length = 370 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 102/400 (25%), Positives = 164/400 (41%), Gaps = 55/400 (13%) Query: 11 FTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSS 70 F + L +L E D + +SP+S++ AL + A+ +T E+ +L Sbjct: 17 FALHLHRRLAEAVPDGEVIWSPYSVACALGVLAAGARATTRTELTTLL------------ 64 Query: 71 VARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKP-RNNYSLRSANRIYVEKTYALL 129 DP LL A ++ ++ L S ++V + Sbjct: 65 ------------GTDP------------APLLAALDRAVTDSPDLASRTVLWVSADVPVR 100 Query: 130 PTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLIL 189 ++ ++ + +F+T PE R +N + T I+ LL V R IL Sbjct: 101 SSFRATMHDRPDSDVRTADFRTNPEGVRATVNADIADATRGMIRELLPQGAVTPDLRAIL 160 Query: 190 VNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPY 249 NA++ KA W F+A T FR + + V M+ T P ++M+ L + Sbjct: 161 TNALWAKARWTTPFEAHLTRAGTFRTPRGPKR-VPFMHRTKTMPYATAR--GWRMVTL-H 216 Query: 250 VKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDR 309 EL++ +LLP L L + T V+L LP+F L Sbjct: 217 AHDELAVDVLLPPGTNAAAVPTAPLLTAL----------HRRSASTSVELALPRFELTQP 266 Query: 310 IDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVIIS 369 L + L G+ T FT +AD G++ L + VIHQ+ + VDE+G E AAATA ++ Sbjct: 267 HQLVEVLAEAGVRTLFTASADLSGISTVP-LYVDTVIHQARLRVDERGAEGAAATAAMML 325 Query: 370 FTTSV-INHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 ++ ++F VD PFH +R + ILF G P Sbjct: 326 LAGAMPPRRTIRFSVDRPFHIVVR--RRGAILFLGSIADP 363 >1MTP-A nrPDB Length = 323 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 83/347 (23%), Positives = 137/347 (39%), Gaps = 52/347 (14%) Query: 11 FTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSS 70 F + L +L E D + +SP+S++ AL + A+ +T E+ +L Sbjct: 13 FALHLHRRLAEAVPDGEVIWSPYSVACALGVLAAGARATTRTELTTLL------------ 60 Query: 71 VARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKP-RNNYSLRSANRIYVEKTYALL 129 DP LL A ++ ++ L S ++V + Sbjct: 61 ------------GTDP------------APLLAALDRAVTDSPDLASRTVLWVSADVPVR 96 Query: 130 PTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLIL 189 ++ ++ + +F+T PE R +N + T I+ LL V R IL Sbjct: 97 SSFRATMHDRPDSDVRTADFRTNPEGVRATVNADIADATRGMIRELLPQGAVTPDLRAIL 156 Query: 190 VNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPY 249 NA++ KA W F+A T FR + + V M+ T P ++M+ L + Sbjct: 157 TNALWAKARWTTPFEAHLTREGTFRTPRGPKR-VPFMHRTKTMPYATAR--GWRMVTL-H 212 Query: 250 VKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDR 309 EL++ +LLP L L + T V+L LP+F L Sbjct: 213 AHDELAVDVLLPPGTNAAAVPTAPLLTAL----------HRRSASTSVELALPRFELTQP 262 Query: 310 IDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEK 356 L + L G+ T FT +AD G++ L + VIHQ+ + VDE+ Sbjct: 263 HQLVEVLAEAGVRTLFTASADLSGISTVP-LYVDTVIHQARLRVDER 308 >5C98-A nrPDB Length = 382 Score = 71.2 bits (173), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 82/408 (20%), Positives = 164/408 (40%), Gaps = 54/408 (13%) Query: 2 EQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFT 61 + + A+ FT++ F + N SP+ + AL++ Y A + + Sbjct: 15 DAIVAANNKFTLEYFKAC--YDEKCNCAVSPYHVRLALSMFYPLAGAAVQEDFQVAFGLP 72 Query: 62 EAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIY 121 E V A ++ + A+ +H G L++ + + Sbjct: 73 EDVHAA----------------IEQQQRLAQQLHDG--------------QHLKALSFVL 102 Query: 122 VEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDV 181 VE+T L + +L + ++ + V+ T S +N++ ++ ++I++ + DV Sbjct: 103 VEETLRLDSEFERLFHRTFQTTVEPVDL-TDDIPSALAVNSFYQR-ANTEIEDFIGEGDV 160 Query: 182 ---KATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIME 238 +L+L + + ++F T+++ F+ ++ V M+ + Sbjct: 161 FSLPPCHKLMLFSGVSVLTPLAIRFNPADTALELFQFINAPTQRVSTMHTTAFVRRCLHN 220 Query: 239 KMNFKMIELPY-VKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLV 297 ++ K++++P+ LSM +LLP DGT L Q+ +T L++ D ++ + Sbjct: 221 ELRCKVVDMPFDAASGLSMLVLLP---YDGTE-LRQIVNSITPAHLAQI-DERLQS-CWT 274 Query: 298 DLHLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKG 357 DL LPKF + ++ D + TL +G F + D D ++ I ++AV E G Sbjct: 275 DLKLPKFFVREKTDPKQTLGKLGYGGVFEID-DLHVFHDSGRTRLNGFIQHCYLAVSESG 333 Query: 358 TEAAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRF 405 + A F +F + PF F IR +L G F Sbjct: 334 SGIPAPPDTPSEF---------EFHANRPFMFLIRRTMDGNVLQVGNF 372 >5M3Y-A nrPDB Length = 458 Score = 35.4 bits (80), Expect = 0.050, Method: Compositional matrix adjust. Identities = 40/200 (20%), Positives = 89/200 (44%), Gaps = 16/200 (8%) Query: 211 QPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPYVKRELSMFILLPDDIKDGTTG 270 Q F + ++ S V M+ TF + F + ++P+ + S+ ++ P D Sbjct: 265 QEFWVDQSTSVSVPMLSGMGTFQHWSDIQDQFSVTQVPFTESA-SLLLIQPHYASD---- 319 Query: 271 LEQLERELTYERLS-EWADSKMMTETLVDLHLPKFSLEDRIDLRDTLRNMGMTTAFTTNA 329 L+++E LT+++ S W K ++ + L +P+ L+ DL+D L + T Sbjct: 320 LDKVEG-LTFQQNSLNWM--KKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTEL 376 Query: 330 DFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVIISFTTSVINHVLKFKVDHPFHF 389 + + +++ + + + +V++ F ++ E +T + VL+ ++ PF F Sbjct: 377 NLQKLSNDR-IRVGEVLNSIFFELEADEREPTESTQQLNK------PEVLEVTLNRPFLF 429 Query: 390 FIRHNKSKTILFFGRFCCPV 409 + + + F GR P+ Sbjct: 430 AVYDQSATALHFLGRVANPL 449 >3I44-A nrPDB Length = 497 Score = 31.6 bits (70), Expect = 0.64, Method: Compositional matrix adjust. Identities = 18/47 (38%), Positives = 23/47 (48%) Query: 177 SSDDVKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPV 223 S A TR+++ AIY KA K AEKT + P + N PV Sbjct: 299 SGQSCNAPTRMLVEQAIYDKAIKTAKDIAEKTQVGPGHQTGNHIGPV 345 >2QYS-A nrPDB Length = 318 Score = 28.9 bits (63), Expect = 3.8, Method: Compositional matrix adjust. Identities = 15/38 (39%), Positives = 21/38 (55%), Gaps = 2/38 (5%) Query: 366 VIISFTTSVINHVLK--FKVDHPFHFFIRHNKSKTILF 401 +I T + NH++K K+ HP + F R N SKT L Sbjct: 15 LIFGGTGYIGNHMVKGSLKLGHPTYVFTRPNSSKTTLL 52 >4G1P-A nrPDB Length = 487 Score = 28.5 bits (62), Expect = 5.4, Method: Compositional matrix adjust. Identities = 17/62 (27%), Positives = 32/62 (51%), Gaps = 2/62 (3%) Query: 146 KVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILVNAIYFKAEWEVKFQA 205 K + +T P+ +++ + V+K ++K K+L S + K T LI A + + +F A Sbjct: 344 KFSIRTVPDMDSEKLTSLVQKHCDAKFKSLNSPN--KCRTELIHDGAYWVSDPFNAQFTA 401 Query: 206 EK 207 K Sbjct: 402 AK 403 >5SUM-A nrPDB Length = 468 Score = 28.1 bits (61), Expect = 7.3, Method: Compositional matrix adjust. Identities = 14/30 (46%), Positives = 20/30 (66%), Gaps = 2/30 (6%) Query: 2 EQVSASIGNFTVDLFNKLN--ETNRDKNIF 29 E V +S+GNF + FN+LN T+ KN+F Sbjct: 319 ENVVSSLGNFQSETFNELNVITTDYKKNVF 348 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6EE5-A nrPDB 499 e-142 2H4P-A nrPDB 472 e-133 1BY7-A nrPDB 454 e-128 2H4Q-A nrPDB 440 e-124 4GA7-A nrPDB 433 e-122 4ZK0-A nrPDB 421 e-118 6HGE-B nrPDB 418 e-117 3NE4-A nrPDB 414 e-116 1HLE-A nrPDB 409 e-115 2OL2-A nrPDB 409 e-114 1UHG-A nrPDB 406 e-114 2VDY-A nrPDB 402 e-112 1ATT-A nrPDB 400 e-112 4EB1-I nrPDB 398 e-111 5HGC-A nrPDB 397 e-111 1C5G-A nrPDB 386 e-108 1YXA-A nrPDB 380 e-106 3DY0-A nrPDB 378 e-105 6F02-A nrPDB 377 e-105 4Y40-A nrPDB 375 e-104 3LW2-A nrPDB 373 e-104 3NDA-A nrPDB 373 e-104 4KDS-A nrPDB 371 e-103 4P0F-A nrPDB 368 e-102 5NCS-A nrPDB 368 e-102 4DY0-A nrPDB 367 e-102 1XQJ-A nrPDB 366 e-102 1QMB-A nrPDB 365 e-101 1JMJ-A nrPDB 364 e-101 4DTE-A nrPDB 358 3e-99 4AJT-A nrPDB 354 5e-98 2XN5-A nrPDB 348 2e-96 2V95-A nrPDB 343 6e-95 5INW-A nrPDB 343 8e-95 6F4U-A nrPDB 343 1e-94 3F02-A nrPDB 342 2e-94 3ZHA-A nrPDB 325 3e-89 5NCU-A nrPDB 325 3e-89 4AJU-A nrPDB 321 2e-88 2R9Y-A nrPDB 316 1e-86 3OZQ-A nrPDB 314 4e-86 1IMV-A nrPDB 314 6e-86 6CJ7-A nrPDB 311 2e-85 3LE2-A nrPDB 310 1e-84 1SEK-A nrPDB 306 1e-83 1K9O-I nrPDB 305 3e-83 3PZF-A nrPDB 301 3e-82 3STO-A nrPDB 288 4e-78 1JJO-C nrPDB 285 2e-77 1SNG-A nrPDB 284 4e-77 2OAY-A nrPDB 276 1e-74 2PEF-A nrPDB 275 2e-74 1C8O-A nrPDB 270 8e-73 1MTP-A nrPDB 254 4e-68 5C98-A nrPDB 252 2e-67 6BJ5-B nrPDB 238 3e-63 1M93-B nrPDB 234 5e-62 Sequences not found previously or not previously below threshold: 2WXZ-C nrPDB 147 1e-35 2WXX-A nrPDB 140 8e-34 5M3Y-A nrPDB 134 9e-32 4R9I-A nrPDB 83 2e-16 5NSQ-A nrPDB 33 0.17 4P2L-A nrPDB 32 0.47 1F2V-A nrPDB 32 0.68 3T59-A nrPDB 32 0.70 3LLI-A nrPDB 31 0.79 2P6F-A nrPDB 31 0.90 4B8O-A nrPDB 30 1.3 4B8J-A nrPDB 30 1.3 2ILV-A nrPDB 30 1.8 5D9K-A nrPDB 30 2.7 1PD0-A nrPDB 30 2.7 1M2V-B nrPDB 30 2.8 5ZI5-A nrPDB 29 4.2 1F4Q-A nrPDB 28 5.3 4KBM-A nrPDB 28 6.9 3HJN-A nrPDB 28 8.5 >6EE5-A nrPDB Length = 379 Score = 499 bits (1286), Expect = e-142, Method: Composition-based stats. Identities = 157/406 (38%), Positives = 236/406 (58%), Gaps = 46/406 (11%) Query: 3 QVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTE 62 +++ + +F L+ +L +++ DKNIFFSP SISSALA+ L AKG T ++ E L F Sbjct: 20 KLAEANTDFAFSLYRELAKSSPDKNIFFSPVSISSALAMLSLGAKGDTHTQILEGLGFNS 79 Query: 63 AVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYV 122 +IH GF+ LL N+P+ L++AN ++V Sbjct: 80 EA----------------------------DIHQGFQHLLQTLNRPK-GLQLKTANGLFV 110 Query: 123 EKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVK 182 +K+ LL ++L+ SKK Y+AE V+F PE+++K+IN WVEKQT KIK+LL D+ Sbjct: 111 DKSLKLLDSFLEDSKKLYQAEAFSVDFD--PEEAKKQINDWVEKQTNGKIKDLLK--DLD 166 Query: 183 ATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNF 242 + T L+LVNAIYFK +W+ F E T + F + + + V MM + F ++++ Sbjct: 167 SDTVLVLVNAIYFKGKWKKPFDPENTKEEDFHVDEKTTVKVPMMSQKGKFYYYHDDELSC 226 Query: 243 KMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLP 302 K++ELPY SM I+LPD+ GL+ LE+ LT E LS+W K +T V+L+LP Sbjct: 227 KVLELPYKGN-ASMLIILPDEG-----GLQHLEQSLTPETLSKWL--KSLTRRSVELYLP 278 Query: 303 KFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAA 362 KF +E DL++ L N+G+T F+ AD G+T++K L +SK +H++ + V+E+GTEAAA Sbjct: 279 KFKIEGTYDLKEVLSNLGITDLFSPGADLSGITEEK-LYVSKAVHKAVLEVNEEGTEAAA 337 Query: 363 ATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 AT ++ +FK D PF F IR NK+ +ILF G+ P Sbjct: 338 ATF----LEAIPMSIPPEFKADRPFLFLIRENKTGSILFMGKVVNP 379 >2H4P-A nrPDB Length = 394 Score = 472 bits (1215), Expect = e-133, Method: Composition-based stats. Identities = 369/369 (100%), Positives = 369/369 (100%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF Sbjct: 26 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 85 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI Sbjct: 86 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 145 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD Sbjct: 146 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 205 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM Sbjct: 206 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 265 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH Sbjct: 266 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 325 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEA 360 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEA Sbjct: 326 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEA 385 Query: 361 AAATAVIIS 369 AAATAVIIS Sbjct: 386 AAATAVIIS 394 >1BY7-A nrPDB Length = 382 Score = 454 bits (1169), Expect = e-128, Method: Composition-based stats. Identities = 165/409 (40%), Positives = 251/409 (61%), Gaps = 28/409 (6%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 ME + + F ++LF L + + +N+F SPWSISS +A+ Y+ ++GST +MA+VL F Sbjct: 1 MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQF 60 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 E A A+ IHS F+ L +A N NY L S N++ Sbjct: 61 NEVGAA------------------------ADKIHSSFRSLSSAINASTGNYLLESVNKL 96 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 + EK+ + Y++L +KYY +EPQ V+F E++RK+IN+WV+ QT+ KI NLL Sbjct: 97 FGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGS 156 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 V TR++LVNA+YFK +W+ F+ + + PFR++ + PV+MMY+R+ + +E + Sbjct: 157 VDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDL 216 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 +++ELPY +SMF+LLPD+I D +TGLE LE E+TY++L++W M E V+++ Sbjct: 217 KAQILELPYAGD-VSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVY 275 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTTN-ADFRGMTDKKDLAISKVIHQSFVAVDEKGTE 359 +P+F LE+ +LR LR+MGM AF A+F GM+++ DL +S+V HQ+ V V+E+GTE Sbjct: 276 IPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTE 335 Query: 360 AAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 AAA T +++ T + +F DHPF F I H + ILFFGRF P Sbjct: 336 AAAGTGGVMTGRTG--HGGPQFVADHPFLFLIMHKITNCILFFGRFSSP 382 >2H4Q-A nrPDB Length = 382 Score = 440 bits (1132), Expect = e-124, Method: Composition-based stats. Identities = 340/369 (92%), Positives = 340/369 (92%), Gaps = 28/369 (7%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF Sbjct: 42 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 101 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 EQAENIHSGFKELLTAFNKPRNNYSLRSANRI Sbjct: 102 ----------------------------EQAENIHSGFKELLTAFNKPRNNYSLRSANRI 133 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD Sbjct: 134 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 193 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM Sbjct: 194 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 253 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH Sbjct: 254 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 313 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEA 360 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEA Sbjct: 314 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEA 373 Query: 361 AAATAVIIS 369 AATAVIIS Sbjct: 374 VAATAVIIS 382 >4GA7-A nrPDB Length = 389 Score = 433 bits (1114), Expect = e-122, Method: Composition-based stats. Identities = 178/409 (43%), Positives = 245/409 (59%), Gaps = 31/409 (7%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 MEQ+S++ F +DLF L+E N NIF SP+SISSA+A+ +L +G+TA ++++ HF Sbjct: 11 MEQLSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHF 70 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 E +HS F+ L NK +Y L+ ANR+ Sbjct: 71 N----------------------------TVEEVHSRFQSLNADINKRGASYILKLANRL 102 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 Y EKTY LP +L ++K Y A+ V+F+ A E +RK IN WV+ QTE KI LL+S Sbjct: 103 YGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTINQWVKGQTEGKIPELLASGM 162 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 V T+L+LVNAIYFK W+ KF E T+ PFRL+K K VKMMY + F +E + Sbjct: 163 VDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMMYQKKKFAYGYIEDL 222 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 +++ELPY ELSM ILLPDDI+D +TGL+++E +LT E+L EW + + V++ Sbjct: 223 KCRVLELPYQGEELSMVILLPDDIEDESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVS 282 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAF-TTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTE 359 LP+F LE+ L L +G+ F ++ AD GM+ +D+ ISK++H+SFV V+E+GTE Sbjct: 283 LPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGMSGARDIFISKIVHKSFVEVNEEGTE 342 Query: 360 AAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 AAAATA I +F F DHPF FFIRHN S +ILF GRF P Sbjct: 343 AAAATAGIATFCMDDPEE--NFTADHPFLFFIRHNSSGSILFLGRFSSP 389 >4ZK0-A nrPDB Length = 390 Score = 421 bits (1083), Expect = e-118, Method: Composition-based stats. Identities = 170/408 (41%), Positives = 251/408 (61%), Gaps = 18/408 (4%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 M +S + F DLF + + +++ NIF+SP SI+SAL + L AK +TA+++ +VLHF Sbjct: 1 MNSLSEANTKFMFDLFQQFRK-SKENNIFYSPISITSALGMVLLGAKDNTAQQIKKVLHF 59 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 + + A +++ N+H F++LLT FNK + Y L+ AN++ Sbjct: 60 DQVTENTTGKAAT------------YHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKL 107 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 + EKTY L YL KK+Y+ + V+F APE+SRK+IN+WVE QT KIKNL+ + Sbjct: 108 FGEKTYLFLQEYLDAIKKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIKNLIPEGN 167 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 + + T L+LVNAIYFK +WE KF E T + F +KN K ++MM +F +E + Sbjct: 168 IGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTSFHFASLEDV 227 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 K++E+PY ++LSM +LLP++I GL++LE +LT E+L EW + M ET VDLH Sbjct: 228 QAKVLEIPYKGKDLSMIVLLPNEID----GLQKLEEKLTAEKLMEWTSLQNMRETRVDLH 283 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEA 360 LP+F +E+ DL+DTLR MGM F +AD GMT + L +S V+H++FV V E+ Sbjct: 284 LPRFKVEESYDLKDTLRTMGMVDIFNGDADLSGMTGSRGLVLSGVLHKAFVEVTEE-GAE 342 Query: 361 AAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 AAA ++ F +S + +F +HPF FFIR NK+ +ILF+GRF P Sbjct: 343 AAAATAVVGFGSSPTSTNEEFHCNHPFLFFIRQNKTNSILFYGRFSSP 390 >6HGE-B nrPDB Length = 409 Score = 418 bits (1075), Expect = e-117, Method: Composition-based stats. Identities = 126/408 (30%), Positives = 214/408 (52%), Gaps = 35/408 (8%) Query: 4 VSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEA 63 ++++ +F L+ +L DKN+ FSP SIS+ALA L A +T E+ + L F Sbjct: 35 LASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLT 94 Query: 64 VRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVE 123 +E+ IH F+ LL N+ + L N ++V+ Sbjct: 95 ETSEA------------------------EIHQSFQHLLRTLNQSSDELQLSMGNAMFVK 130 Query: 124 KTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKA 183 + +LL + + +K+ Y +E +F+ + ++K IN +V+ T KI +L+ D+ + Sbjct: 131 EQLSLLDRFTEDAKRLYGSEAFATDFQDSA-AAKKLINDYVKNGTRGKITDLIK--DLDS 187 Query: 184 TTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRD-TFPVLIMEKMNF 242 T ++LVN I+FKA+WE+ F + T F LSK K V MM + T P E+++ Sbjct: 188 QTMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSC 247 Query: 243 KMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLP 302 +++L Y ++FI LPD K +E++E L+ E L+ W DS E +L+LP Sbjct: 248 TVVQLNYTGNASALFI-LPDQDK-----MEEVEAMLSRETLNRWGDSLEFREIG-ELYLP 300 Query: 303 KFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAA 362 KFS+ +L D L +G+ AFT+ AD G+T ++LA+S+V+H++ + V E+GTEA+A Sbjct: 301 KFSISRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQVVHKAVLDVFEEGTEASA 360 Query: 363 ATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPVE 410 ATAV I+ ++++ + + PF I + + +I F + P + Sbjct: 361 ATAVKITLLSALVETRTIVRFNRPFLMIIVDHFTWSIFFMSKVTNPKQ 408 >3NE4-A nrPDB Length = 424 Score = 414 bits (1065), Expect = e-116, Method: Composition-based stats. Identities = 119/409 (29%), Positives = 208/409 (50%), Gaps = 39/409 (9%) Query: 2 EQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFT 61 +++ ++ F L+ +L + NIFFSP SI++A A+ L K T E+ E L+F Sbjct: 54 NKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFN 113 Query: 62 EAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIY 121 E+ IH GF+ELL N+P + L + N ++ Sbjct: 114 LTEIPEA------------------------QIHEGFQELLRTLNQPDSQLQLTTGNGLF 149 Query: 122 VEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDV 181 + + L+ +L+ KK Y +E VNF E+++K+IN +VEK T+ KI +L+ ++ Sbjct: 150 LSEGLKLVDKFLEDVKKLYHSEAFTVNFGDT-EEAKKQINDYVEKGTQGKIVDLVK--EL 206 Query: 182 KATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMN 241 T LVN I+FK +WE F+ + T + F + + + V MM F + +K++ Sbjct: 207 DRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLS 266 Query: 242 FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHL 301 ++ + Y+ ++F LPD+ K L+ LE ELT++ ++++ +++ LHL Sbjct: 267 SWVLLMKYLGNATAIFF-LPDEGK-----LQHLENELTHDIITKFLENE--DRRSASLHL 318 Query: 302 PKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAA 361 PK S+ DL+ L +G+T F+ AD G+T++ L +SK +H++ + +DEKGTEAA Sbjct: 319 PKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAA 378 Query: 362 AATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPVE 410 A + ++ + K + PF F + +K+ LF G+ P + Sbjct: 379 GA----MFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPTQ 423 >1HLE-A nrPDB Length = 345 Score = 409 bits (1052), Expect = e-115, Method: Composition-based stats. Identities = 155/355 (43%), Positives = 216/355 (60%), Gaps = 29/355 (8%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 MEQ+S + +F VDLF LNE++ NIF SP SISSALA+ +L +G+TA ++++ L+F Sbjct: 2 MEQLSTANTHFAVDLFRALNESDPTGNIFISPLSISSALAMIFLGTRGNTAAQVSKALYF 61 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 + E+IHS F+ L NKP Y L+ ANR+ Sbjct: 62 ----------------------------DTVEDIHSRFQSLNADINKPGAPYILKLANRL 93 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 Y EKTY L +L ++K Y AE V+F+ APE +RKEIN WV+ QTE KI LL Sbjct: 94 YGEKTYNFLADFLASTQKMYGAELASVDFQQAPEDARKEINEWVKGQTEGKIPELLVKGM 153 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 V T+L+LVNAIYFK W+ KF E T PFRL+K +K VKMMY + FP +E + Sbjct: 154 VDNMTKLVLVNAIYFKGNWQQKFMKEATRDAPFRLNKKDTKTVKMMYQKKKFPYNYIEDL 213 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 +++ELPY +ELSM ILLPDDI+D +TGLE++E++LT ++L EW + + V++H Sbjct: 214 KCRVLELPYQGKELSMIILLPDDIEDESTGLEKIEKQLTLDKLREWTKPENLYLAEVNVH 273 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTTN-ADFRGMTDKKDLAISKVIHQSFVAVD 354 LP+F LE+ DL L +G+ F AD GM+ +DL +SK+IH+SFV ++ Sbjct: 274 LPRFKLEESYDLTSHLARLGVQDLFNRGKADLSGMSGARDLFVSKIIHKSFVDLN 328 >2OL2-A nrPDB Length = 395 Score = 409 bits (1050), Expect = e-114, Method: Composition-based stats. Identities = 125/404 (30%), Positives = 210/404 (51%), Gaps = 39/404 (9%) Query: 5 SASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAV 64 +S +FT DL+ L +NIFFSP SIS +LA+ L A ST ++ E L Sbjct: 31 PSSRRDFTFDLYRALASAAPSQNIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQK 90 Query: 65 RAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEK 124 +E + +H GF++LL N+PR+ + L N ++ + Sbjct: 91 SSE------------------------KELHRGFQQLLQELNQPRDGFQLSLGNALFTDL 126 Query: 125 TYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKAT 184 L T++ K Y A+ NF+ + + K+IN +V KQT+ KI +LL ++ + Sbjct: 127 VVDLQDTFVSAMKTLYLADTFPTNFRDSA-GAMKQINDYVAKQTKGKIVDLLK--NLDSN 183 Query: 185 TRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKM 244 +I+VN I+FKA+WE F + T Q F ++ V MM D + L+ ++ ++ Sbjct: 184 AVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRV 243 Query: 245 IELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKF 304 + +PY ++FI LP + K ++Q+E L+ + L +W KM + ++L+LPKF Sbjct: 244 VGVPYQGNATALFI-LPSEGK-----MQQVENGLSEKTLRKWL--KMFKKRQLELYLPKF 295 Query: 305 SLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAAT 364 S+E L L ++G++ FT++AD G+++ ++ +S+++H++ V VDE GT AAAAT Sbjct: 296 SIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAAT 355 Query: 365 AVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 I +F ++ +N + + PF FI N ILF G+ P Sbjct: 356 GTIFTFRSARLNS-QRLVFNRPFLMFIVDN---NILFLGKVNRP 395 >1UHG-A nrPDB Length = 385 Score = 406 bits (1044), Expect = e-114, Method: Composition-based stats. Identities = 140/406 (34%), Positives = 229/406 (56%), Gaps = 22/406 (5%) Query: 3 QVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTE 62 + A+ F D+F +L + ++NIF+ P +I SALA+ YL AK ST ++ +V+ F + Sbjct: 2 SIGAASMEFCFDVFKELKVHHANENIFYCPIAIMSALAMVYLGAKDSTRTQINKVVRFDK 61 Query: 63 AVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYV 122 ++ + + N+HS +++L KP + YS A+R+Y Sbjct: 62 LP--------------GFGDSIEAQCGTSVNVHSSLRDILNQITKPNDVYSFSLASRLYA 107 Query: 123 EKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVK 182 E+ Y +LP YLQ K+ Y+ + +NF+TA +Q+R+ IN+WVE QT I+N+L V Sbjct: 108 EERYPILPEYLQCVKELYRGGLEPINFQTAADQARELINSWVESQTNGIIRNVLQPSSVD 167 Query: 183 ATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNF 242 + T ++LVNAI FK WE F+ E T PFR+++ +SKPV+MMY F V M Sbjct: 168 SQTAMVLVNAIVFKGLWEKAFKDEDTQAMPFRVTEQESKPVQMMYQIGLFRVASMASEKM 227 Query: 243 KMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLP 302 K++ELP+ +SM +LLPD++ +GLEQLE + +E+L+EW S +M E + ++LP Sbjct: 228 KILELPFASGTMSMLVLLPDEV----SGLEQLESIINFEKLTEWTSSNVMEERKIKVYLP 283 Query: 303 KFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAA 362 + +E++ +L L MG+T F+++A+ G++ + L IS+ +H + ++E G E Sbjct: 284 RMKMEEKYNLTSVLMAMGITDVFSSSANLSGISSAESLKISQAVHAAHAEINEAGREVVG 343 Query: 363 ATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 + + + F+ DHPF F I+H + +LFFGR P Sbjct: 344 SAEAGVDAASVSEE----FRADHPFLFCIKHIATNAVLFFGRCVSP 385 >2VDY-A nrPDB Length = 373 Score = 402 bits (1034), Expect = e-112, Method: Composition-based stats. Identities = 112/406 (27%), Positives = 193/406 (47%), Gaps = 39/406 (9%) Query: 4 VSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEA 63 ++++ +F L+ L + KNIF SP SIS ALA+ L G T ++ + L F Sbjct: 7 LASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLT 66 Query: 64 VRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVE 123 R+E+ IH GF+ L F K + + N ++++ Sbjct: 67 ERSET------------------------EIHQGFQHLHQLFAKSDTSLEMTMGNALFLD 102 Query: 124 KTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKA 183 + LL ++ K YY++E +NF+ SR+ IN++V+ +T+ KI +L S + + Sbjct: 103 GSLELLESFSADIKHYYESEVLAMNFQDWATASRQ-INSYVKNKTQGKIVDLFSG--LDS 159 Query: 184 TTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFK 243 L+LVN I+FK W F T + F + + V MM T L ++ + Sbjct: 160 PAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQ 219 Query: 244 MIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPK 303 ++++ YV ++F +LPD K + + L+ + ++ W S +T + VDL++PK Sbjct: 220 LVQMNYVGNG-TVFFILPDKGK-----MNTVIAALSRDTINRW--SAGLTSSQVDLYIPK 271 Query: 304 FSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAA 363 ++ DL D L MG+ FTT A+F +T L SKV+H++ + ++E+GTEAA A Sbjct: 272 VTISGVYDLGDVLEEMGIADLFTTQANFSRITQDAQLKSSKVVHKAVLQLNEEGTEAAGA 331 Query: 364 TAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 + + + + + PF I + + + LF R PV Sbjct: 332 ----MFLEAIPRSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV 373 >1ATT-A nrPDB Length = 429 Score = 400 bits (1027), Expect = e-112, Method: Composition-based stats. Identities = 128/412 (31%), Positives = 214/412 (51%), Gaps = 36/412 (8%) Query: 3 QVSASIGNFTVDLFNKLNET-NRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFT 61 ++S + +F + L ++ N + NIF SP SIS+A A+T L A +T ++ EV F Sbjct: 47 ELSKANSHFATAFYQHLADSKNNNDNIFLSPLSISTAFAMTKLGACNNTLTQLMEVFKFD 106 Query: 62 EAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFN-KPRNNYSLRSANRI 120 + ++ IH F +L K + L SANR+ Sbjct: 107 -----------------------TISEKTSDQIHFFFAKLNCRLYRKANKSSELVSANRL 143 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 + +K+ TY +S+ Y A+ Q ++FK EQSR IN W+ +TE +I +++ Sbjct: 144 FGDKSITFNETYQDISEVVYGAKLQPLDFKGNAEQSRLTINQWISNKTEGRITDVIPPQA 203 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 + T L+LVN IYFK W+ KF E T + F + +S V MMY F + + Sbjct: 204 INEFTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSVLMMYQESKFRYRRVAE- 262 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 + +++ELP+ +++M ++LP K L ++E+ELT + L EW D +TETL+ +H Sbjct: 263 STQVLELPFKGDDITMVLILPKLEKT----LAKVEQELTPDMLQEWLDE--LTETLLVVH 316 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTT-NADFRGMT--DKKDLAISKVIHQSFVAVDEKG 357 +P+F +ED +++ L++MG+ F+ + G+ + DL +S H++F+ V+E+G Sbjct: 317 MPRFRIEDSFSVKEQLQDMGLEDLFSPEKSRLPGIVAEGRSDLYVSDAFHKAFLEVNEEG 376 Query: 358 TEAAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 +EAAA+T + I+ S+ + + FK + PF IR TI+F GR P Sbjct: 377 SEAAASTVISIA-GRSLNSDRVTFKANRPFLVLIREVALNTIIFMGRVANPC 427 >4EB1-I nrPDB Length = 440 Score = 398 bits (1023), Expect = e-111, Method: Composition-based stats. Identities = 132/420 (31%), Positives = 211/420 (50%), Gaps = 44/420 (10%) Query: 3 QVSASIGNFTVDLFNKLN-ETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFT 61 ++S + F + L N + NIF SP SIS+A A+T L A T +++ EV F Sbjct: 50 ELSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFD 109 Query: 62 EAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFN-KPRNNYSLRSANRI 120 + ++ IH F +L K L SANR+ Sbjct: 110 -----------------------TISEKTSDQIHFFFAKLNCRLYRKANKASKLVSANRL 146 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 + +K+ TY +S+ Y A+ Q ++FK EQSR IN WV +TE +I +++ S+ Sbjct: 147 FGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEA 206 Query: 181 VK--------ATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTF 232 + +T L+LVN IYFK W+ KF E T + F + +S MMY F Sbjct: 207 INVLVLVNTRTSTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSASMMYQEGKF 266 Query: 233 PVLIMEKMNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMM 292 + + +++ELP+ +++M ++LP K L ++E+ELT E L EW D + Sbjct: 267 RYRRVAE-GTQVLELPFKGDDITMVLILPKPEK----SLAKVEKELTPEVLQEWLDE--L 319 Query: 293 TETLVDLHLPKFSLEDRIDLRDTLRNMGMTTAFTT-NADFRGMT--DKKDLAISKVIHQS 349 E ++ +H+P+F +ED L++ L++MG+ F+ + G+ + DL +S H++ Sbjct: 320 EEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKA 379 Query: 350 FVAVDEKGTEAAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 F+ V+E+G+EAAA+TAV+I+ + N V FK + PF FIR TI+F GR P Sbjct: 380 FLEVNEEGSEAAASTAVVIAGRSLNPNRV-TFKANRPFLVFIREVPLNTIIFMGRVANPC 438 >5HGC-A nrPDB Length = 380 Score = 397 bits (1020), Expect = e-111, Method: Composition-based stats. Identities = 127/407 (31%), Positives = 201/407 (49%), Gaps = 39/407 (9%) Query: 3 QVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTE 62 ++ + +F F ++ + +KNIF+SP SIS+A A+ L A+ +T ++ E L F Sbjct: 10 KLVPNNADFAFQFFREVTQEAPNKNIFYSPVSISTAFAMLALGARSATQSQILEGLAFNL 69 Query: 63 AVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYV 122 E + IH GF L+ N P L N I+V Sbjct: 70 TEIQE------------------------KEIHEGFHNLIHMLNHPEGGVQLNMMNAIFV 105 Query: 123 EKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVK 182 ALL +L +K Y+ E +F P ++ K+IN ++E++T KI NL+ D+ Sbjct: 106 TAALALLRKFLDDAKALYQLEAFTTDF-NKPTEAEKQINDYIERKTHGKITNLVK--DMD 162 Query: 183 ATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNF 242 T ++L + +YFK WE F+AE T + F + + V MMY F E+++ Sbjct: 163 PQTVMLLASFVYFKGSWEKPFEAEHTEEREFFVDAETTVKVPMMYQMGRFDFYFDEELSC 222 Query: 243 KMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLP 302 ++ L Y + F++LP K ++QLE+ L E + +W+D + + ++L+ P Sbjct: 223 TVVRLHYNGSATA-FLVLPAKGK-----MKQLEQTLDKETIQKWSDH--LFQRFMNLYFP 274 Query: 303 KFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAA 362 KFS+ ++ +TLR MG+ FT AD G+T DL +SKV+H++ + VDEKGTEAAA Sbjct: 275 KFSISGSYEISNTLRKMGIVDVFTNQADLSGITGSPDLKVSKVVHKASLDVDEKGTEAAA 334 Query: 363 ATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 ATAV I I+ + HPF I + + LF G+ P Sbjct: 335 ATAVEI----MPISFPPTIEFSHPFLMLIFDRDTNSTLFIGKIVNPT 377 >1C5G-A nrPDB Length = 402 Score = 386 bits (992), Expect = e-108, Method: Composition-based stats. Identities = 114/404 (28%), Positives = 196/404 (48%), Gaps = 41/404 (10%) Query: 9 GNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAES 68 +F V +F ++ + ++D+N+ FSP+ ++S LA+ L G T +++ + F + + Sbjct: 36 SDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMA 95 Query: 69 SSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYAL 128 + L P N + + + I+V++ L Sbjct: 96 P---------------------------ALRHLYKELMGPWNKDEISTTDAIFVQRDLKL 128 Query: 129 LPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLI 188 + ++ + +++ ++V+F + E++R IN WV+ T+ I NLL V TRL+ Sbjct: 129 VQGFMPHFFRLFRSTVKQVDF-SEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLV 187 Query: 189 LVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPV---LIMEKMNFKMI 245 LVNA+YF +W+ F T + F S + V MM + F + + ++ Sbjct: 188 LVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDIL 247 Query: 246 ELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFS 305 ELPY LSMFI P + + L L L+ + +S W + MT L LPKFS Sbjct: 248 ELPYHGDTLSMFIAAPYEKE---VPLSALTNILSAQLISHWKGN--MTRLPRLLVLPKFS 302 Query: 306 LEDRIDLRDTLRNMGMTTAFTT-NADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAAT 364 LE +DLR L N+GMT F ADF ++D++ L +++ + + + V+E GT A+++T Sbjct: 303 LETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSST 362 Query: 365 AVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 AVI+S + ++ D PF F +RHN + T+LF G+ P Sbjct: 363 AVIVSARMAPEEIIM----DRPFLFVVRHNPTGTVLFMGQVMEP 402 >1YXA-A nrPDB Length = 398 Score = 380 bits (976), Expect = e-106, Method: Composition-based stats. Identities = 134/406 (33%), Positives = 208/406 (51%), Gaps = 36/406 (8%) Query: 4 VSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEA 63 +++ +F L+ +L N D NI FSP SIS+ALAL L AKG+T E+ E L F Sbjct: 27 LASINTDFAFSLYKELVLKNPDTNIVFSPLSISAALALVSLGAKGNTLEEILEGLKFNLT 86 Query: 64 VRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVE 123 +E+ +IH GF LL N+P++ + + + +++E Sbjct: 87 ETSEA------------------------DIHQGFGHLLQRLNQPKDQVQISTGSALFIE 122 Query: 124 KTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKA 183 K +L + + +K Y+AE +F+ P Q++K IN +V KQT+ IK L+S D+ Sbjct: 123 KRQQILTEFQEKAKTLYQAEAFTADFQQ-PRQAKKLINDYVRKQTQGMIKELVS--DLDK 179 Query: 184 TTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRD-TFPVLIMEKMNF 242 T ++LVN IYFKA+W+V F T F K + V MM M D T P E+++ Sbjct: 180 RTLMVLVNYIYFKAKWKVPFDPLDTFKSEFYCGKRRPVIVPMMSMEDLTTPYFRDEELSC 239 Query: 243 KMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLP 302 ++EL Y ++FI LPD + ++Q+E L E L +W +S + +LHLP Sbjct: 240 TVVELKYTGNASALFI-LPDQGR-----MQQVEASLQPETLRKWKNSLK-PRMIDELHLP 292 Query: 303 KFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAA 362 KFS+ L D L +G+ F+T AD +T KDL +S+V+H++ + V E GTEAAA Sbjct: 293 KFSISTDYSLEDVLSKLGIREVFSTQADLSAITGTKDLRVSQVVHKAVLDVAETGTEAAA 352 Query: 363 ATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 AT V ++ + + L + PF I +++ F + P Sbjct: 353 ATGVKFVPMSAKL-YPLTVYFNRPFLIMIFDTETEIAPFIAKIANP 397 >3DY0-A nrPDB Length = 336 Score = 378 bits (970), Expect = e-105, Method: Composition-based stats. Identities = 114/366 (31%), Positives = 193/366 (52%), Gaps = 35/366 (9%) Query: 5 SASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAV 64 +S +FT DL+ L +NIFFSP SIS +LA+ L A ST ++ E L Sbjct: 6 PSSRRDFTFDLYRALASAAPSQNIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQK 65 Query: 65 RAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEK 124 +E + +H GF++LL N+PR+ + L N ++ + Sbjct: 66 SSE------------------------KELHRGFQQLLQELNQPRDGFQLSLGNALFTDL 101 Query: 125 TYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKAT 184 L T++ K Y A+ NF+ + + K+IN +V KQT+ KI +LL ++ + Sbjct: 102 VVDLQDTFVSAMKTLYLADTFPTNFRDSA-GAMKQINDYVAKQTKGKIVDLLK--NLDSN 158 Query: 185 TRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKM 244 +I+VN I+FKA+WE F + T Q F ++ V MM D + L+ ++ ++ Sbjct: 159 AVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRV 218 Query: 245 IELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKF 304 + +PY ++FI LP + K ++Q+E L+ + L +W KM + ++L+LPKF Sbjct: 219 VGVPYQGNATALFI-LPSEGK-----MQQVENGLSEKTLRKWL--KMFKKRQLELYLPKF 270 Query: 305 SLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAAT 364 S+E L L ++G++ FT++AD G+++ ++ +S+++H++ V VDE GT AAAAT Sbjct: 271 SIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAAT 330 Query: 365 AVIISF 370 I +F Sbjct: 331 GTIFTF 336 >6F02-A nrPDB Length = 389 Score = 377 bits (967), Expect = e-105, Method: Composition-based stats. Identities = 115/411 (27%), Positives = 192/411 (46%), Gaps = 37/411 (9%) Query: 3 QVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTE 62 +++ + +F + + KNIFFSP SIS+A A+ L A + ++ E L F Sbjct: 6 KIAPANADFAFRFYYLIASETPGKNIFFSPLSISAAYAMLSLGACSHSRSQILEGLGFNL 65 Query: 63 AVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYV 122 +ES ++H GF+ LL N P + R + +++ Sbjct: 66 TELSES------------------------DVHRGFQHLLHTLNLPGHGLETRVGSALFL 101 Query: 123 EKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVK 182 L +L + Y+A+ NF + + IN V+K+T KI +L+S ++K Sbjct: 102 SHNLKFLAKFLNDTMAVYEAKLFHTNFYDTV-GTIQLINDHVKKETRGKIVDLVS--ELK 158 Query: 183 ATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFP-VLIMEKMN 241 ++LVN IYFKA WE F + +T+ + F + +N + V MM L + Sbjct: 159 KDVLMVLVNYIYFKALWEKPFISSRTTPKDFYVDENTTVRVPMMLQDQEHHWYLHDRYLP 218 Query: 242 FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWAD--SKMMTETLVDL 299 ++ + Y ++F +LP+ K + ++E LT E L W + K ++L Sbjct: 219 CSVLRMDYKGD-ATVFFILPNQGK-----MREIEEVLTPEMLMRWNNLLRKRNFYKKLEL 272 Query: 300 HLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTE 359 HLPKFS+ L L +G T F+ AD G+T ++ L SK H++ + VDE GTE Sbjct: 273 HLPKFSISGSYVLDQILPRLGFTDLFSKWADLSGITKQQKLEASKSFHKATLDVDEAGTE 332 Query: 360 AAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPVE 410 AAAAT+ I F ++ N + + + PF I ++++LF G+ P + Sbjct: 333 AAAATSFAIKFFSAQTNRHI-LRFNRPFLVVIFSTSTQSVLFLGKVVDPTK 382 >4Y40-A nrPDB Length = 414 Score = 375 bits (963), Expect = e-104, Method: Composition-based stats. Identities = 105/408 (25%), Positives = 198/408 (48%), Gaps = 41/408 (10%) Query: 2 EQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFT 61 ++++ + L KL N +NIF SP SIS+A ++ L A+ ST E+ + +F Sbjct: 46 KELARQNMDLGFKLLKKLAFYNPGRNIFLSPLSISTAFSMLCLGAQDSTLDEIKQGFNFR 105 Query: 62 EAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIY 121 + +++H GF ++ + + L N ++ Sbjct: 106 KMPE--------------------------KDLHEGFHYIIHELTQKTQDLKLSIGNTLF 139 Query: 122 VEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDV 181 +++ +L+ +K +Y AE NF+ E ++K+IN ++ ++T KI NL+ +++ Sbjct: 140 IDQRLQPQRKFLEDAKNFYSAETILTNFQN-LEMAQKQINDFISQKTHGKINNLI--ENI 196 Query: 182 KATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMN 241 T ++L N I+F+A W+ +F T + F L KN S V MM+ + V +K++ Sbjct: 197 DPGTVMLLANYIFFRARWKHEFDPNVTKEEDFFLEKNSSVKVPMMFRSGIYQVGYDDKLS 256 Query: 242 FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHL 301 ++E+PY K ++FI LPD+ K L+ LE+ L + S W +++ +V + + Sbjct: 257 CTILEIPYQKNITAIFI-LPDEGK-----LKHLEKGLQVDTFSRW--KTLLSRRVVCVSV 308 Query: 302 PKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAA 361 P+ + DL+ TL +G++ F + D + + L + + +H++ + +DE+GTE A Sbjct: 309 PRLHMTGTFDLKKTLSYIGVSKIFEEHGDLTKIAPHRSLKVGEAVHKAELKMDERGTEGA 368 Query: 362 AATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 A T T + L K+D P+ I K ++LF G+ P+ Sbjct: 369 AGTGA----QTLPMETPLCVKIDKPYLLLIYSEKIPSVLFLGKIVNPI 412 >3LW2-A nrPDB Length = 379 Score = 373 bits (959), Expect = e-104, Method: Composition-based stats. Identities = 115/404 (28%), Positives = 198/404 (49%), Gaps = 41/404 (10%) Query: 9 GNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAES 68 +F V +F ++ + ++D+N+ FSP+ +SS LA+ + G T R++ + + F + + Sbjct: 13 TDFGVKVFQQVVQASKDRNVVFSPYGVSSVLAMLQMTTAGKTRRQIQDAMGFKVNEKGTA 72 Query: 69 SSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYAL 128 ++L P N + +A+ I+V++ L Sbjct: 73 ---------------------------HALRQLSKELMGPWNKNEISTADAIFVQRDLEL 105 Query: 129 LPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLI 188 + ++ K ++ ++V+F + E++R IN WVE+ T+ I +LL+ V TRL+ Sbjct: 106 VQGFMPHFFKLFQTMVKQVDF-SEVERARFIINDWVERHTKGMINDLLAKGAVDELTRLV 164 Query: 189 LVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPV---LIMEKMNFKMI 245 LVNA+YF +W+ F T + F S + V MM + F + + + ++ Sbjct: 165 LVNALYFSGQWKTPFLEASTHQRLFHKSDGSTVSVPMMAQSNKFNYTEFTTPDGLEYDVV 224 Query: 246 ELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFS 305 ELPY LSMFI P + L L L E + +W + MT L LPKFS Sbjct: 225 ELPYQGDTLSMFIAAPFEKD---VHLSALTNILDAELIRQWKGN--MTRLPRLLILPKFS 279 Query: 306 LEDRIDLRDTLRNMGMTTAFTTN-ADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAAT 364 LE +DLR L +GM F+ ADF ++D++ L++++ + + + V+E GT A+++T Sbjct: 280 LETEVDLRGPLEKLGMPDMFSATLADFTSLSDQEQLSVAQALQKVRIEVNESGTVASSST 339 Query: 365 AVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 A +IS + V +D F F +RHN ++TILF G+ P Sbjct: 340 AFVISARMAPTEMV----IDRSFLFVVRHNPTETILFMGQVMEP 379 >3NDA-A nrPDB Length = 377 Score = 373 bits (957), Expect = e-104, Method: Composition-based stats. Identities = 117/404 (28%), Positives = 202/404 (50%), Gaps = 34/404 (8%) Query: 3 QVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTE 62 +++ + F + L L + +KN+FFSP+S+S+A+ + + A+G T +E+++ L F++ Sbjct: 6 KLTKANNRFGLRLLRAL-PSGPEKNVFFSPYSVSTAMGMAFAGARGQTQQELSQGLGFSD 64 Query: 63 AVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYV 122 ++ + + +N +L AN + Sbjct: 65 VDLTDAG------------------------VLDAYTHHTERLKSTPSNSTLDVANAAAI 100 Query: 123 EKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVK 182 ++T ALL +Y + + AE KV+F P+ + +N WV+++T KI+ L ++ + Sbjct: 101 QRTLALLNSYESALQSSFGAELHKVDFAGEPQAAVDFVNNWVKRKTHDKIEKLF-NEPLD 159 Query: 183 ATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNF 242 T L+L+NAIYFK EW F E T + F V M + + + Sbjct: 160 PDTLLVLLNAIYFKGEWNTAFVKEHTEKRQFFNGGVTPVEVDTMRLEARIKYRFFDDLQV 219 Query: 243 KMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLP 302 +++ELPY + +M ILLP + TG+E L++ LT +R + + E + + LP Sbjct: 220 EVVELPYRGLDYTMAILLPKE----NTGVEGLKQNLTIDRFQNYLSD--LRERKITVLLP 273 Query: 303 KFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAA 362 KF LE + L+ L+++G+ F + AD G+ D L +S V H++ V V+E+GT AAA Sbjct: 274 KFKLETKYSLKAPLQSLGIKQIFESGADLSGIND-GSLRVSAVEHKAVVEVNEEGTVAAA 332 Query: 363 ATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFC 406 T V+I S+ + F+VDHPF FFIR+ ++ I F G+ Sbjct: 333 TTGVVIV-PYSLGPEPVVFRVDHPFLFFIRNTRTDDIFFVGQVN 375 >4KDS-A nrPDB Length = 386 Score = 371 bits (952), Expect = e-103, Method: Composition-based stats. Identities = 110/406 (27%), Positives = 198/406 (48%), Gaps = 44/406 (10%) Query: 9 GNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAES 68 +F + +F+++ + ++ N+ FSP+ +++ LA+ L A G+T + + L F+ R + Sbjct: 20 TDFGMRVFSQVAQNSKGSNLAFSPYGVATILAMAQLGAGGNTLKTLNAKLGFSLQERGMA 79 Query: 69 SSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYAL 128 + LL L A+ + VE+ AL Sbjct: 80 RQ----------------------------QRLLQRDISSEEGVEL--ASGVMVERKMAL 109 Query: 129 LPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLI 188 + + K ++A P +++F + P+Q+ IN WV T I + LSS + TR++ Sbjct: 110 EKGFRRGLGKAFQASPHQLDF-SRPDQALDIINAWVSDHTAGTIPSFLSSGALTDETRMV 168 Query: 189 LVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVL---IMEKMNFKMI 245 L+NA++F+ W+V F + T + F + S PV MM + F + +++ +I Sbjct: 169 LLNALHFQGLWKVPFDPKMTEERLFHCANGSSVPVPMMRLTHRFKYGEFVTPDGVDYDVI 228 Query: 246 ELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFS 305 E+PY LSM ++ P + + T + L ELT +RL +W + M L LP+F+ Sbjct: 229 EVPYEGESLSMLLVSPFEPE---TPVSSLSSELTTQRLQQW--RQEMRSVKRQLVLPRFT 283 Query: 306 LEDRIDLRDTLRNMGMTTAFT-TNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAAT 364 L+ ++L+ L MG+ F ADF +T ++ L +SKV+ + + V+E+GT+A+AAT Sbjct: 284 LDSEVELKSILIQMGLGDMFNLAKADFTRITTEQPLCVSKVLQKVKIEVNEEGTKASAAT 343 Query: 365 AVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPVE 410 A I+ + V + ++ PF F I H + +LF G+ P + Sbjct: 344 AAILFSRMA----VEEITMNRPFLFLIHHKSTGAVLFMGQVNQPQQ 385 >4P0F-A nrPDB Length = 393 Score = 368 bits (944), Expect = e-102, Method: Composition-based stats. Identities = 123/409 (30%), Positives = 208/409 (50%), Gaps = 40/409 (9%) Query: 2 EQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFT 61 ++ + + F+++++ KL+ +NI FSP+SI + A+ L A+ TA ++ + L Sbjct: 8 QEFARRLALFSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQLDQGLGLA 67 Query: 62 EAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIY 121 + E I F ++L A+ +++ LR AN+I+ Sbjct: 68 SS--------------------------DPEQIAHSFHQVLAAY---QDSQILRIANKIF 98 Query: 122 VEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDV 181 V Y L + QL K + + Q V+F Q+ IN WVE++T IK+L+ +D + Sbjct: 99 VMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNV-QAAATINNWVEQRTNHLIKDLVPADVL 157 Query: 182 KATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMN 241 + +RL+LVNAI+FK W+ +F T F L ++ V MM +++ F + ++ Sbjct: 158 NSESRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGERTVQVPMMSLKERFRYADLPALD 217 Query: 242 FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHL 301 +ELPY +LSM I+LP+ TGL LE +L LS+ S + ET V L L Sbjct: 218 AMALELPYKDSDLSMLIVLPN----TKTGLPALEEKLRLTTLSQITQS--LYETKVALKL 271 Query: 302 PKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKK-DLAISKVIHQSFVAVDEKGTEA 360 P+F E +++L + + +GM+ F+ A+F M L +S +IH++F+ V+E+GTEA Sbjct: 272 PRFKAEFQVELSEVFQKLGMSRMFSDQAEFGKMLQSPEPLKVSAIIHKAFIEVNEEGTEA 331 Query: 361 AAATAVIISFTTSV--INHVLKFKVDHPFHFFIRHNKSKTILFFGRFCC 407 AAAT + + ++ ++F DHPF + + H K LF+G Sbjct: 332 AAATGMAVRRKRAIMSPEEPIEFFADHPFTYVLVHQKD-LPLFWGSVVR 379 >5NCS-A nrPDB Length = 375 Score = 368 bits (944), Expect = e-102, Method: Composition-based stats. Identities = 121/406 (29%), Positives = 187/406 (46%), Gaps = 43/406 (10%) Query: 2 EQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFT 61 E++ F DL + + N+F SP S+S AL +T A G TA EM L T Sbjct: 6 EKIEKDNA-FAFDLLQTTRKHVTEANVFISPLSVSMALNMTLNGAAGVTADEMKTALRET 64 Query: 62 EAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIY 121 E+I+ L A K + ++ AN I+ Sbjct: 65 GYTM--------------------------EDINEYSHSLREALLKVDPSTTIGMANSIW 98 Query: 122 VEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDV 181 ++ + ++ ++ +Y AE + V+F + + IN W ++T KI +L D + Sbjct: 99 YKQGELVKEPFILANRTHYDAEVKAVDFSSPA--TLPAINGWCAQKTNDKITKIL--DYI 154 Query: 182 KATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMN 241 + L+NA+YFK W +F+ T PFR + ++ V MM + TF E Sbjct: 155 PGNAFMYLINAVYFKGIWVTQFKKSDTKRAPFRKADGTTQEVNMMAQKSTFGYTTDEC-- 212 Query: 242 FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEW-ADSKMMTETLVDLH 300 + +E+ Y + SM ++LP++ + +EQL+ W K + T V L Sbjct: 213 CQYLEMDYGNKAFSMIVMLPNEGQTTRDVIEQLDN-------KHWSMIIKGIRPTQVSLR 265 Query: 301 LPKFSLEDRIDL-RDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTE 359 +P+F E + L + L MGM FT ADF G+TD + IS+VIH++FV VDE+GTE Sbjct: 266 MPRFKTECKYGLEKKILPEMGMNVPFTETADFPGITDAA-IFISRVIHKTFVQVDEEGTE 324 Query: 360 AAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRF 405 AAA TAV + T+S + F ++ PF F IR + ILF G Sbjct: 325 AAAVTAVEMVKTSSPSTTPINFHINKPFVFAIREKSTGVILFIGEI 370 >4DY0-A nrPDB Length = 379 Score = 367 bits (943), Expect = e-102, Method: Composition-based stats. Identities = 115/414 (27%), Positives = 198/414 (47%), Gaps = 48/414 (11%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 +E++ ++ + +FN++ ++ NI SP I+S L + L A G T +++A V+ + Sbjct: 8 LEELGSNT---GIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRY 64 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 + K++ A +N + AN + Sbjct: 65 -----------------------------GVNGVGKILKKINKAIVSKKNKDIVTVANAV 95 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 +V+ + ++ +K ++ E + VNF+ P + IN WV+ +T I NLLS D Sbjct: 96 FVKNASEIEVPFVTRNKDVFQCEVRNVNFED-PASACDSINAWVKNETRDMIDNLLSPDL 154 Query: 181 VKAT-TRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLI--- 236 + TRL+LVNA+YFK W+ +FQ E T + F + KS V M+ F Sbjct: 155 IDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSA 214 Query: 237 MEKMNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETL 296 + + IELPY +SM I LP + +T L + ++ + + W +M Sbjct: 215 PNDLWYNFIELPYHGESISMLIALPTE---SSTPLSAIIPHISTKTIDSWMS--IMVPKR 269 Query: 297 VDLHLPKFSLEDRIDLRDTLRNMGMTTAF-TTNADFRGM-TDKKDLAISKVIHQSFVAVD 354 V + LPKF+ + DL++ L+ +G+T F ++ A+F + T ++L +S ++ ++ + V Sbjct: 270 VQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVS 329 Query: 355 EKGTEAAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 E GT+A+AAT I+ +S F VD PF FFIRHN + +LF G+ P Sbjct: 330 EDGTKASAATTAILIARSSPP----WFIVDRPFLFFIRHNPTGAVLFMGQINKP 379 >1XQJ-A nrPDB Length = 389 Score = 366 bits (940), Expect = e-102, Method: Composition-based stats. Identities = 141/409 (34%), Positives = 234/409 (57%), Gaps = 35/409 (8%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 M+ + + F VDLF +L+E N+ FSP ++S++L+L + AKG TA E+ +VLHF Sbjct: 15 MDALQLANSAFAVDLFKQLSEKEPLGNVLFSPIALSTSLSLAQVGAKGDTANEIGQVLHF 74 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 E +++ GF+ + + NK + YSL+ R+ Sbjct: 75 ----------------------------ENVKDVPFGFQTVTSDVNKLSSFYSLKLIKRL 106 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 YV+K+ L ++ +K+ Y E + V+FK E+++ +IN ++ T+ +N+L+ + Sbjct: 107 YVDKSLNLSTEFISSTKRPYAKELETVDFKDKLEETKGQINNSIKDLTDGHFENILADNS 166 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 V T++++VNA YF +W KF +T PFR++K +KPV+MM M TF + ++ + Sbjct: 167 VNDQTKILVVNAAYFVGKWMKKFSESETKESPFRVNKTDTKPVQMMNMEATFSMGNIDSI 226 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 N K+IELP+ + LSMFILLP D++D +TGLE++E++L E LS+W + M V L Sbjct: 227 NSKIIELPFQNKHLSMFILLPKDVEDESTGLEKIEKQLNSESLSQWTNPSTMANAKVKLS 286 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTTN-ADFRGMTDKKDLAISKVIHQSFVAVDEKGTE 359 +PKF +E ID + +L N+G+ F+ + +DF GM++ K +A+S VIH+ + + E G + Sbjct: 287 IPKFKVEKMIDPKASLENLGLKHIFSEDTSDFSGMSETKGVALSNVIHKVSLEITEDGGD 346 Query: 360 AAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 + I + H + DHPF + IRHNK++ I+FFG+F P Sbjct: 347 SIEVPGARI------LQHKDELNADHPFIYIIRHNKTRNIIFFGKFSSP 389 >1QMB-A nrPDB Length = 326 Score = 365 bits (937), Expect = e-101, Method: Composition-based stats. Identities = 110/362 (30%), Positives = 189/362 (52%), Gaps = 37/362 (10%) Query: 3 QVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTE 62 +++ ++ F L+ +L + NIFFSP SI++A A+ L K T E+ E L+F Sbjct: 1 KITPNLAEFAFSLYRQLAHQS-STNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNL 59 Query: 63 AVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYV 122 E++ IH GF+ELL N+P + L + N +++ Sbjct: 60 TEIPEAA------------------------IHEGFQELLRTLNQPDSQLQLTTGNGLFL 95 Query: 123 EKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVK 182 + L+ +L+ KK Y +E VNF E+++K+IN +VEK T+ KI +L+ ++ Sbjct: 96 SEGLKLVDKFLEDVKKLYHSEAFTVNFGDT-EEAKKQINDYVEKGTQGKIVDLVK--ELD 152 Query: 183 ATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNF 242 T LVN I+FK +WE F+ + T + F + + + V MM F + +K++ Sbjct: 153 RDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSS 212 Query: 243 KMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLP 302 ++ + Y+ ++F LPD+ K L+ LE ELT++ ++++ ++ LHLP Sbjct: 213 WVLLMKYLGNATAIFF-LPDEGK-----LQHLENELTHDIITKFLEN---DRRSASLHLP 263 Query: 303 KFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAA 362 K S+ DL+ L +G+T F+ AD G+T++ L +SK +H++ + +DEKGTEAA Sbjct: 264 KLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAG 323 Query: 363 AT 364 A Sbjct: 324 AM 325 >1JMJ-A nrPDB Length = 480 Score = 364 bits (935), Expect = e-101, Method: Composition-based stats. Identities = 117/409 (28%), Positives = 205/409 (50%), Gaps = 36/409 (8%) Query: 1 MEQVSASIGNFTVDLFNKLN-ETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLH 59 +++++ F +L+ L + N NIF +P IS+A+ + L KG T ++ +LH Sbjct: 104 IQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILH 163 Query: 60 FTEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANR 119 F + V A S + IH+ F++L + Y+LRS N Sbjct: 164 FKDFVNASSKY-------------------EITTIHNLFRKLTHRLFRRNFGYTLRSVND 204 Query: 120 IYVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSD 179 +Y++K + +L + ++YY AE Q +F S+ N + K T+ IK+ L + Sbjct: 205 LYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKT--NNHIMKLTKGLIKDAL--E 260 Query: 180 DVKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEK 239 ++ T+++++N IYFK W KF E T FRL++ + V MM + F ++ Sbjct: 261 NIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQE 320 Query: 240 MNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDL 299 ++ +++L YV +SM I++P + +G++ LE +LT + W K MT ++ Sbjct: 321 LDCDILQLEYVGG-ISMLIVVPHKM----SGMKTLEAQLTPRVVERW--QKSMTNRTREV 373 Query: 300 HLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTE 359 LPKF LE +L ++L+ MG+ F N + G++D++ +AI HQ + V+E+GT+ Sbjct: 374 LLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQR-IAIDLFKHQGTITVNEEGTQ 432 Query: 360 AAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 A T V ++ ++F VD PF F I +++ +LF GR P Sbjct: 433 ATTVTTVGF----MPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANP 477 >4DTE-A nrPDB Length = 374 Score = 358 bits (918), Expect = 3e-99, Method: Composition-based stats. Identities = 101/406 (24%), Positives = 189/406 (46%), Gaps = 44/406 (10%) Query: 9 GNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAES 68 +F + +F + ++ D+N+ SP+ I+S L + + A G+T + +A + ++ R Sbjct: 8 TDFGLQVFAEAVQSAPDRNLALSPYGIASVLGMAQMGAYGATLKLLASKMGYSLQERGMP 67 Query: 69 SSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYAL 128 + LL + A+ + V++ L Sbjct: 68 K----------------------------LQRLLQRDLASEDGVE--VASGVMVDRKIIL 97 Query: 129 LPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLI 188 + + K +++ P +++F + PE +R+ IN+W T+ I L S + TRL+ Sbjct: 98 EKVFRRSLSKAFQSVPHQIDF-SQPEMARQVINSWTSDHTDGMISEFLPSGVLSELTRLV 156 Query: 189 LVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIM---EKMNFKMI 245 +NA++F W+ F T Q F + V MM F + +++ +I Sbjct: 157 FLNALHFHGVWKTPFDPRNTREQLFHTVNGSAVSVPMMTTTQKFNYGEFVSKDGVDYDVI 216 Query: 246 ELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFS 305 E+PY +SM ++ P + L L +EL+ R+ +W + M + L +P+FS Sbjct: 217 EMPYEGESISMLLVTPFEKD---VPLSALNKELSSSRIHQW--RQEMRKISKQLSIPRFS 271 Query: 306 LEDRIDLRDTLRNMGMTTAFT-TNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAAT 364 ++ IDL+ TL MG+ F+ + ADF +T ++ L +SKV+ + + V+E+GT+ ++AT Sbjct: 272 MDTEIDLKSTLSRMGLGDIFSQSRADFSRITTEEPLCVSKVLQRVKLEVNEEGTKGSSAT 331 Query: 365 AVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPVE 410 A +I + V + +D PF F I+H + +LF G+ P E Sbjct: 332 AAVIYSRMA----VEEITLDRPFFFLIQHKPTGALLFSGQLTQPQE 373 >4AJT-A nrPDB Length = 427 Score = 354 bits (908), Expect = 5e-98, Method: Composition-based stats. Identities = 116/410 (28%), Positives = 193/410 (47%), Gaps = 42/410 (10%) Query: 2 EQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFT 61 +Q+S +F +L K++ D N+ FSP+ +S A+ L KG T ++ L+ Sbjct: 56 QQLSNETSSFGFNLLRKIS-MRHDGNVIFSPFGLSVAMVNLMLGTKGETKVQIENGLNLQ 114 Query: 62 EAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIY 121 +A + FK++ F+ R+ L + + Sbjct: 115 ALSQAGPLILPAL-----------------------FKKVKETFSSNRD-LGLSQGSFAF 150 Query: 122 VEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDV 181 + K + + TY LSKKY+ E +NF+ + Q+R IN + K+TE KI L D++ Sbjct: 151 IHKDFDIKETYFNLSKKYFDIEYVSINFQNS-SQARGLINHCIVKETEGKIPKLF--DEI 207 Query: 182 KATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMN 241 T+LILV+ + FK +W F T F L K ++ V MMY F +K Sbjct: 208 NPETKLILVDYVLFKGKWLTPFDPSFTEADTFHLDKYRAIKVPMMYREGNFTSTFDKKFR 267 Query: 242 FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHL 301 +++LPY +M ++L + D LE LT + + W + M +++ Sbjct: 268 CHILKLPYQGN-ATMLVVLMEKTGDYL----ALEDYLTVDLVETWL--QNMKTRKMEVFF 320 Query: 302 PKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTD-KKDLAISKVIHQSFVAVDEKGTEA 360 PKF L R ++ + L+ MG+ F+T+AD ++ ++L +S+V+ QS + VDE+GTEA Sbjct: 321 PKFKLNQRYEMHELLKQMGIRRLFSTSADLSELSAMARNLQVSRVLQQSVLEVDERGTEA 380 Query: 361 AAAT-AVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 + T + II+++ KV+ PFHF I S+ +LF GR P Sbjct: 381 VSGTLSEIIAYSM-----PPAIKVNRPFHFIIYEEMSRMLLFLGRVVNPT 425 >2XN5-A nrPDB Length = 350 Score = 348 bits (894), Expect = 2e-96, Method: Composition-based stats. Identities = 109/378 (28%), Positives = 186/378 (49%), Gaps = 36/378 (9%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 + ++S+ +F +L+ + DKNIFFSP SIS+AL + A ST E+ E L F Sbjct: 8 LYKMSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGF 67 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 I GF+ L+ + N P+ L+ N + Sbjct: 68 NLTDTP------------------------MVEIQHGFQHLICSLNFPKKELELQIGNAL 103 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 ++ K L +L K Y+ E +F + +++EIN+ VE QT+ K+ L+ D Sbjct: 104 FIGKHLKPLAKFLNDVKTLYETEVFSTDF-SNISAAKQEINSHVEMQTKGKVVGLI--QD 160 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQP-FRLSKNKSKPVKMMYMRDTFPVLIMEK 239 +K T ++LVN I+FKA+W F KT F + K + V MM+ + + L+ + Sbjct: 161 LKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDME 220 Query: 240 MNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDL 299 +N ++++ Y K L++F+ LP + + +E +E ++ + L +W ++++ + VDL Sbjct: 221 LNCTVLQMDYSKNALALFV-LPKEGQ-----MESVEAAMSSKTLKKW--NRLLQKGWVDL 272 Query: 300 HLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTE 359 +PKFS+ DL TL MG+ A++ NADF G+T+ L +S H++ + + EKGTE Sbjct: 273 FVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEKGTE 332 Query: 360 AAAATAVIISFTTSVINH 377 AA A + + Sbjct: 333 AAGAMFLEAIPRSIPNTF 350 >2V95-A nrPDB Length = 371 Score = 343 bits (881), Expect = 6e-95, Method: Composition-based stats. Identities = 93/405 (22%), Positives = 179/405 (44%), Gaps = 43/405 (10%) Query: 4 VSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEA 63 ++ + +F +L+ +L N DKN SP SIS ALA+ L + + + L F Sbjct: 9 LAPTNVDFAFNLYQRLVALNPDKNTLISPVSISMALAMVSLGSA---QTQSLQSLGFNLT 65 Query: 64 VRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVE 123 +E+ IH F+ L + + N +++ Sbjct: 66 ETSEA------------------------EIHQSFQYLNYLLKQSDTGLEMNMGNAMFLL 101 Query: 124 KTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKA 183 + L ++L K+YY++E ++F+ + S ++IN V+ +T+ KI+++ S D+ + Sbjct: 102 QKLKLKDSFLADVKQYYESEALAIDFEDWTKAS-QQINQHVKDKTQGKIEHVFS--DLDS 158 Query: 184 TTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFK 243 ILVN I+ + WE+ F E T + F +++ + V MM + + Sbjct: 159 PASFILVNYIFLRGIWELPFSPENTREEDFYVNETSTVKVPMMVQSGSIGYFRDSVFPCQ 218 Query: 244 MIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPK 303 +I++ YV + FI LPD + ++ + L+ + + W K+MT V+L++PK Sbjct: 219 LIQMDYVGNGTAFFI-LPDQGQ-----MDTVIAALSRDTIDRWG--KLMTPRQVNLYIPK 270 Query: 304 FSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAA 363 FS+ D DL+D L ++ + T +DF G T L ++ ++H++ + +DE + Sbjct: 271 FSMSDTYDLKDVLEDLNIKDLLTNQSDFSGNTKDVPLTLT-MVHKAMLQLDEGNVLPNST 329 Query: 364 TAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 + + L K + PF + + + L + P Sbjct: 330 NGAPLHLRS----EPLDIKFNKPFILLLFDKFTWSSLMMSQVVNP 370 >5INW-A nrPDB Length = 421 Score = 343 bits (880), Expect = 8e-95, Method: Composition-based stats. Identities = 101/372 (27%), Positives = 172/372 (46%), Gaps = 31/372 (8%) Query: 2 EQVSASIGNFTVDLFNK-LNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 +++++++ L+ + L NIFFSP SI+SAL + A GST E+ L F Sbjct: 79 QRIASAVNGLGFRLYKQVLGGAGPADNIFFSPLSIASALGVVTAGANGSTRAELDTALGF 138 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 E + + + + F L A K + L N + Sbjct: 139 KEFLHGKKKAKSM----------------------KYFARLNGALYKRSAGFELMGKNVV 176 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 + +K L + + +K+ + V+F + + + + +N ++EK T K +++S D Sbjct: 177 FSKKGLWLYRQFTRTVAHLFKSNVRSVDFGDS-KNAVELMNAYIEKVTSKKFPDVIS--D 233 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 V T L++VN IYFK W KF+ + T F ++ + S V M+ R K+ Sbjct: 234 VDTDTSLVIVNVIYFKGSWGNKFEPDLTKNVRFWVNSSYSMMVPTMHQRAKLSYTQDRKL 293 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 +++LPY SM +++P +D L ++E ++ E+L EW + V L Sbjct: 294 RSTVVKLPYEGG-ASMLVIVPHRTED----LPKVEESVSQEQLEEWLSLLGPSNHYVQLS 348 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEA 360 LPKF + DL+ L MGM++ F+ AD +T + L + K+ H+S + V+E+GTEA Sbjct: 349 LPKFKISVSYDLKAYLSAMGMSSMFSYGADLSRITGMQKLHVDKITHKSVLHVNEEGTEA 408 Query: 361 AAATAVIISFTT 372 A T V I Sbjct: 409 KAETVVGIMAAP 420 >6F4U-A nrPDB Length = 341 Score = 343 bits (879), Expect = 1e-94, Method: Composition-based stats. Identities = 96/355 (27%), Positives = 161/355 (45%), Gaps = 36/355 (10%) Query: 3 QVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTE 62 +++ + +F + + KNIFFSP SIS+A A+ L A + ++ E L F Sbjct: 4 KIAPANADFAFRFYYLIASETPGKNIFFSPLSISAAYAMLSLGACSHSRSQILEGLGFNL 63 Query: 63 AVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYV 122 +ES ++H GF+ LL N P + R + +++ Sbjct: 64 TELSES------------------------DVHRGFQHLLHTLNLPGHGLETRVGSALFL 99 Query: 123 EKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVK 182 L +L + Y+A+ NF + + IN V+K+T KI +L+S ++K Sbjct: 100 SHNLKFLAKFLNDTMAVYEAKLFHTNFYDTV-GTIQLINDHVKKETRGKIVDLVS--ELK 156 Query: 183 ATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFP-VLIMEKMN 241 ++LVN IYFKA WE F + +T+ + F + +N + V MM L + Sbjct: 157 KDVLMVLVNYIYFKALWEKPFISSRTTPKDFYVDENTTVRVPMMLQDQEHHWYLHDRYLP 216 Query: 242 FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWAD--SKMMTETLVDL 299 ++ + Y ++F +LP+ K + ++E LT E L W + K ++L Sbjct: 217 CSVLRMDYKGD-ATVFFILPNQGK-----MREIEEVLTPEMLMRWNNLLRKRNFYKKLEL 270 Query: 300 HLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVD 354 HLPKFS+ L L +G T F+ AD G+T ++ L SK H++ + VD Sbjct: 271 HLPKFSISGSYVLDQILPRLGFTDLFSKWADLSGITKQQKLEASKSFHKATLDVD 325 >3F02-A nrPDB Length = 359 Score = 342 bits (877), Expect = 2e-94, Method: Composition-based stats. Identities = 109/368 (29%), Positives = 188/368 (51%), Gaps = 39/368 (10%) Query: 6 ASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVR 65 +I + +V+++N+L T D+NI FSP SI+ A+ + L A+GST +E+ + + Sbjct: 21 EAIADLSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLKN 80 Query: 66 AESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKT 125 E S KE + Y ++ AN ++V+ Sbjct: 81 GEEF--------------------------SFLKEFSNMVTAKESQYVMKIANSLFVQNG 114 Query: 126 YALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATT 185 + + +LQ+ KKY+ A V+F + IN WVE T + +K+L+S D A T Sbjct: 115 FHVNEEFLQMMKKYFNAAVNHVDFSQNVAVANY-INKWVENNTNNLVKDLVSPRDFDAAT 173 Query: 186 RLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMN---- 241 L L+NA+YFK W+ +F+ E T F + MMY + F + Sbjct: 174 YLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAG 233 Query: 242 --FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDL 299 ++++E+PY E+SM ++L L LE + + + EWA+S + + V++ Sbjct: 234 GIYQVLEIPYEGDEISMMLVLSRQ----EVPLATLEPLVKAQLVEEWANS--VKKQKVEV 287 Query: 300 HLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTE 359 +LP+F++E IDL+D L+ +G+T F +A+ G++D K++ +SK IH+SF+ V+E+G+E Sbjct: 288 YLPRFTVEQEIDLKDVLKALGITEIFIKDANLTGLSDNKEIFLSKAIHKSFLEVNEEGSE 347 Query: 360 AAAATAVI 367 AAA + +I Sbjct: 348 AAAVSGMI 355 >3ZHA-A nrPDB Length = 392 Score = 325 bits (832), Expect = 3e-89, Method: Composition-based stats. Identities = 107/407 (26%), Positives = 185/407 (45%), Gaps = 42/407 (10%) Query: 4 VSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEA 63 ++ L+ + + +NI SP ++S+L L L K +TA + VL Sbjct: 9 LAERSAGLAFSLYQAMAKDQAVENILLSPVVVASSLGLVSLGGKATTASQAKAVL----- 63 Query: 64 VRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAF-NKPRNNYSLRSANRIYV 122 E + E +H+G ELL + N N + + +R+Y Sbjct: 64 ---------------------SAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYG 102 Query: 123 EKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVK 182 + + +++ SK++Y E K+NF+ + + IN W + T+ K+ + + DV+ Sbjct: 103 PSSVSFAEDFVRSSKQHYNCEHSKINFRDK-RSALQSINEWAAQTTDGKLPEV--TKDVE 159 Query: 183 ATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNF 242 T +LVNA++FK W+ KF + + F ++++ + V MM+ + EK Sbjct: 160 RTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEKL 219 Query: 243 KMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLP 302 +++E+P + S+ IL+P ++ LE+LE+ LT E+L W M + V + LP Sbjct: 220 QIVEMPLAHKLSSLIILMPHHVE----PLERLEKLLTKEQLKIWMGK--MQKKAVAISLP 273 Query: 303 KFSLEDRIDLRDTLRNMGMTTAFTTN-ADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAA 361 K +E DL+ L +G+T A N AD M+ KKDL ++ V H + D +G Sbjct: 274 KGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFEWDTEGNPFD 333 Query: 362 AATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 + + F DHPF F +R +S ++LF GR P Sbjct: 334 QD-----IYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRP 375 >5NCU-A nrPDB Length = 336 Score = 325 bits (832), Expect = 3e-89, Method: Composition-based stats. Identities = 110/372 (29%), Positives = 171/372 (45%), Gaps = 43/372 (11%) Query: 2 EQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFT 61 E++ F DL + + N+F SP S+S AL +T A G TA EM L T Sbjct: 6 EKIEKDNA-FAFDLLQTTRKHVTEANVFISPLSVSMALNMTLNGAAGVTADEMKTALRET 64 Query: 62 EAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIY 121 E+I+ L A K + ++ AN I+ Sbjct: 65 GYTM--------------------------EDINEYSHSLREALLKVDPSTTIGMANSIW 98 Query: 122 VEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDV 181 ++ + ++ ++ +Y AE + V+F + + IN W ++T KI +L D + Sbjct: 99 YKQGELVKEPFILANRTHYDAEVKAVDFSSPA--TLPAINGWCAQKTNDKITKIL--DYI 154 Query: 182 KATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMN 241 + L+NA+YFK W +F+ T PFR + ++ V MM + TF E Sbjct: 155 PGNAFMYLINAVYFKGIWVTQFKKSDTKRAPFRKADGTTQEVNMMAQKSTFGYTTDEC-- 212 Query: 242 FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEW-ADSKMMTETLVDLH 300 + +E+ Y + SM ++LP++ + +EQL+ W K + T V L Sbjct: 213 CQYLEMDYGNKAFSMIVMLPNEGQTTRDVIEQLDN-------KHWSMIIKGIRPTQVSLR 265 Query: 301 LPKFSLEDRIDL-RDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTE 359 +P+F E + L + L MGM FT ADF G+TD + IS+VIH++FV VDE+GTE Sbjct: 266 MPRFKTECKYGLEKKILPEMGMNVPFTETADFPGITDAA-IFISRVIHKTFVQVDEEGTE 324 Query: 360 AAAATAVIISFT 371 AAA TAV + T Sbjct: 325 AAAVTAVEMVKT 336 >4AJU-A nrPDB Length = 387 Score = 321 bits (824), Expect = 2e-88, Method: Composition-based stats. Identities = 95/371 (25%), Positives = 166/371 (44%), Gaps = 36/371 (9%) Query: 2 EQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFT 61 +Q++ NF L K++ D N+ FSP+ +S A+ L A G T ++ LH Sbjct: 52 QQLAKETSNFGFSLLRKIS-MRHDGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQ 110 Query: 62 EAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIY 121 + + S FK L L + + Sbjct: 111 ALKPTKPGL-----------------------LPSLFKGLRETL-SRNLELGLTQGSFAF 146 Query: 122 VEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDV 181 + K + + T+ LSK+Y+ E +NF+ Q+++ +N ++ K+T KI L D++ Sbjct: 147 IHKDFDVKETFFNLSKRYFDTECVPMNFRN-ASQAKRLMNHYINKETRGKIPKLF--DEI 203 Query: 182 KATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMN 241 T+LILV+ I FK +W F T + F L K K+ V MMY F + Sbjct: 204 NPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFASTFDKNFR 263 Query: 242 FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHL 301 +++LPY +M ++L + + D LE LT + + W + M +++ Sbjct: 264 CHVLKLPYQGN-ATMLVVLMEKMGDHL----ALEDYLTTDLVETWL--RNMKTRNMEVFF 316 Query: 302 PKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMT-DKKDLAISKVIHQSFVAVDEKGTEA 360 PKF L+ + ++ + LR MG+ F+ AD ++ ++L +S+V+ ++ + VDE+GTEA Sbjct: 317 PKFKLDQKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDERGTEA 376 Query: 361 AAATAVIISFT 371 A I+ Sbjct: 377 VAGILSEITAR 387 >2R9Y-A nrPDB Length = 430 Score = 316 bits (809), Expect = 1e-86, Method: Composition-based stats. Identities = 110/407 (27%), Positives = 192/407 (47%), Gaps = 52/407 (12%) Query: 3 QVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTE 62 +++ ++ FT DLF+ + +T+ N+ SP S++ AL+ L A+ T + VLH Sbjct: 20 RLAQAMMAFTTDLFSLVAQTSTSSNLVLSPLSVALALSHLALGAQNQTLHSLHRVLHM-- 77 Query: 63 AVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYV 122 N S LL+ F + ++R A RIY+ Sbjct: 78 ------------------------------NTGSCLPHLLSHFYQNLGPGTIRLAARIYL 107 Query: 123 EKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVK 182 +K + + +L+ S++ + A+P K+ K E+ IN WV++ TE KI++ LS ++ Sbjct: 108 QKGFPIKDDFLEQSERLFGAKPVKLTGKQ--EEDLANINQWVKEATEGKIEDFLS--ELP 163 Query: 183 ATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRD-TFPVLIMEKMN 241 +T L+L+NAI+F W KF T F L + + V MM+ ++E+ Sbjct: 164 DSTVLLLLNAIHFHGFWRTKFDPSLTQKDFFHLDERFTVSVDMMHAVSYPLRWFLLEQPE 223 Query: 242 FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHL 301 ++ P+ K +S +++P + + ++ LT++ L + E + L Sbjct: 224 IQVAHFPF-KNNMSFVVVMPTYFE---WNVSEVLANLTWDTLYH----PSLQERPTKVWL 275 Query: 302 PKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAA 361 PK L+ ++DL TL +G+ F D RG++++ +L +S V HQS + + E G EAA Sbjct: 276 PKLHLQQQLDLVATLSQLGLQELF-QGPDLRGISEQ-NLVVSSVQHQSTMELSEAGVEAA 333 Query: 362 AATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 AAT+V ++ + + F V+ PF FFI + LF G P Sbjct: 334 AATSVAMNRMS-----LSSFTVNRPFLFFIMEDTIGVPLFVGSVRNP 375 >3OZQ-A nrPDB Length = 376 Score = 314 bits (805), Expect = 4e-86, Method: Composition-based stats. Identities = 121/409 (29%), Positives = 210/409 (51%), Gaps = 46/409 (11%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 +++ ++ +FT ++ ++ +T + N SP+S ++ LAL +G TA E+ +VLHF Sbjct: 8 LQEFPNAVNSFTPSVYKEVLKTEK-ANFLVSPFSAATLLALAQSGCRGDTAEEIRQVLHF 66 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 +V KE+L+ Y+L +AN+I Sbjct: 67 VGDREKAEGAV---------------------------KEVLSKLT--NEEYTLHTANKI 97 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 YV+ +++ + +++ + Y A+ + V+F + + K +N WVE+QT+ KI+NL+ + Sbjct: 98 YVKTNFSVREEFQKIAVEVYGAQSENVDFSEKNDAA-KLMNAWVEEQTQHKIQNLVDPEI 156 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDT-FPVLIMEK 239 + TR++L+NA+YF A+W V F T F S + V MY+ + F Sbjct: 157 LNNLTRVVLINALYFNAKWLVPFPPFHTRKSDFHKSAKEVVQVDTMYLDEQYFNYYECHH 216 Query: 240 MNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDL 299 ++ K++ELP+ S+ I+L + I+ GL LE ++ L +T+ LV++ Sbjct: 217 LDAKLLELPFKGG-ASLTIVLSNQIE----GLVSLESKIKRSFLPH-----NLTKQLVNV 266 Query: 300 HLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKK-DLAISKVIHQSFVAVDEKGT 358 LPKF +E +D + L+ +G+ AF AD G+ +K DL IS ++ +SF+ V E+G Sbjct: 267 ALPKFKIESTVDFKKVLKKLGVKKAFGDEADLSGIAGEKGDLVISNIVQKSFIDVSEEGV 326 Query: 359 EAAAATAV-IISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFC 406 EAAAAT + +I ++ + +F VDHPF F+I+ ILF GR Sbjct: 327 EAAAATYIPVILPEMALPDSPKQFIVDHPFIFYIK--VKGMILFAGRVT 373 >1IMV-A nrPDB Length = 398 Score = 314 bits (804), Expect = 6e-86, Method: Composition-based stats. Identities = 94/409 (22%), Positives = 180/409 (44%), Gaps = 45/409 (11%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHF 60 + +++A++ NF DL+ + + N+ SP S+++AL+ L A T + L++ Sbjct: 31 VNKLAAAVSNFGYDLYRVRSSMSPTTNVLLSPLSVATALSALSLGADERTESIIHRALYY 90 Query: 61 TEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRI 120 +IH +KELL P+ N L+SA+RI Sbjct: 91 DLISSP--------------------------DIHGTYKELLDTVTAPQKN--LKSASRI 122 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 EK + +++ +K Y P+ + P +EIN WV+ Q + K+ S+ + Sbjct: 123 VFEKKLRIKSSFVAPLEKSYGTRPRVLT--GNPRLDLQEINNWVQAQMKGKLAR--STKE 178 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYM-RDTFPVLIMEK 239 + ++L+ +FK +W KF + KTS++ F L + ++ V MM + + Sbjct: 179 IPDEISILLLGVAHFKGQWVTKFDSRKTSLEDFYLDEERTVRVPMMSDPKAVLRYGLDSD 238 Query: 240 MNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDL 299 ++ K+ +LP +S+ LP + T L +E LT E + + + + L Sbjct: 239 LSCKIAQLPLTG-SMSIIFFLPLKV---TQNLTLIEESLTSEFIHDI--DRELKTVQAVL 292 Query: 300 HLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTE 359 +PK L ++ +L+ M + + F + DF +T K + +++V H++ +E G Sbjct: 293 TVPKLKLSYEGEVTKSLQEMKLQSLFDS-PDFSKITGKP-IKLTQVEHRAGFEWNEDG-- 348 Query: 360 AAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 A T + + L + ++ PF F +R + +LF G+ P Sbjct: 349 --AGTTPSPGLQPAHLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDP 395 >6CJ7-A nrPDB Length = 390 Score = 311 bits (798), Expect = 2e-85, Method: Composition-based stats. Identities = 102/407 (25%), Positives = 186/407 (45%), Gaps = 41/407 (10%) Query: 5 SASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAV 64 + +F V++F ++ T + N+ SP+SI+ LA+ A G+T E+ L T Sbjct: 14 GPASTSFGVNVFKQMA-TEQSGNLAASPFSITILLAMLQQGAAGNTLDEITRALQMTPEK 72 Query: 65 RAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEK 124 AE FK++ K + L++AN +++ + Sbjct: 73 SAEI-----------------------------FKKVNEEIQKRNSRNILKTANNVFLSE 103 Query: 125 TYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKAT 184 + L P + +++ + ++ F P + + IN+W+ +T KI L+S DD+ Sbjct: 104 NFNLNPQFKRIAVNNFDSDLTPTYFG-KPALAAQNINSWIASKTNDKIDKLVSPDDLSGN 162 Query: 185 TRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKM 244 T++++VNA+YFK WE+ F+ + T + F L+ + K M R F + K+ Sbjct: 163 TQMVMVNAVYFKGLWEIPFREQATQKRNFTLNGGEKKVASFMQTRRYFKAGTHKPAMAKV 222 Query: 245 IELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKF 304 + LP+ E S+ ++LP ++ ++ L L+ E ++ + D + V L LPKF Sbjct: 223 VVLPFEYNEYSLIVVLPLK----SSNVDALLSSLSMEDVASFLD---LPPKDVALELPKF 275 Query: 305 SLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDL--AISKVIHQSFVAVDEKGTEAAA 362 S++ I+L L MG+++ FT A+ + L +S +H + + +DE+G +AA Sbjct: 276 SIKADINLEPVLNKMGVSSIFTQQAELYNLGSHGSLSPQVSSALHSAVLTIDERGG-SAA 334 Query: 363 ATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 A + S L F+ + PF + N+S LF R P Sbjct: 335 AATSFAAVALSYDEPSLYFRANKPFLAILWDNRSSIPLFMARIMDPT 381 >3LE2-A nrPDB Length = 393 Score = 310 bits (793), Expect = 1e-84, Method: Composition-based stats. Identities = 97/408 (23%), Positives = 175/408 (42%), Gaps = 41/408 (10%) Query: 12 TVDLFNK-LNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSS 70 +++L + +++ N+ FSP SI+ L++ + G+T ++ L F+ Sbjct: 16 SMNLAKHVITTVSQNSNVIFSPASINVVLSIIAAGSAGATKDQILSFLKFSST------- 68 Query: 71 VARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLP 130 +Q + S + A L AN +++K+ + P Sbjct: 69 ------------------DQLNSFSSEIVSAVLADGSANGGPKLSVANGAWIDKSLSFKP 110 Query: 131 TYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILV 190 ++ QL + YKA + +F++ + E+N+W EK+T I +L + T+LI Sbjct: 111 SFKQLLEDSYKAASNQADFQSKAVEVIAEVNSWAEKETNGLITEVLPEGSADSMTKLIFA 170 Query: 191 NAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPYV 250 NA+YFK W KF T F L M + FK++ LPY+ Sbjct: 171 NALYFKGTWNEKFDESLTQEGEFHLLDGNKVTAPFM--TSKKKQYVSAYDGFKVLGLPYL 228 Query: 251 ----KRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSL 306 KR+ SM+ LPD + L+++ T L + + + +PKF Sbjct: 229 QGQDKRQFSMYFYLPDANNGLSDLLDKIVS--TPGFLDNHIPRRQVKVR--EFKIPKFKF 284 Query: 307 EDRIDLRDTLRNMGMTTAFTTNADFRGMTDKK----DLAISKVIHQSFVAVDEKGTEAAA 362 D + L+ +G+T+ F+ M + +L +S + H++ + V+E+GTEAAA Sbjct: 285 SFGFDASNVLKGLGLTSPFSGEEGLTEMVESPEMGKNLCVSNIFHKACIEVNEEGTEAAA 344 Query: 363 ATAVIISFTTSVINH-VLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 A+A +I ++ + F DHPF + N + +LF G+ P+ Sbjct: 345 ASAGVIKLRGLLMEEDEIDFVADHPFLLVVTENITGVVLFIGQVVDPL 392 >1SEK-A nrPDB Length = 378 Score = 306 bits (784), Expect = 1e-83, Method: Composition-based stats. Identities = 113/412 (27%), Positives = 193/412 (46%), Gaps = 44/412 (10%) Query: 1 MEQVSASIGN-FTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLH 59 ++++ + FT +F+++ + N +N+ S +S+ L LA+ G + E+ L Sbjct: 7 LQKILRESNDQFTAQMFSEVVKANPGQNVVLSAFSVLPPLGQLALASVGESHDELLRALA 66 Query: 60 FTEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANR 119 + F +L + L+ A++ Sbjct: 67 LPNDNVTKDV----------------------------FADLNRGV-RAVKGVDLKMASK 97 Query: 120 IYVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSD 179 IYV K L + +S+ + +E Q V+F + E + IN WVE QT ++IKNL+ D Sbjct: 98 IYVAKGLELNDDFAAVSRDVFGSEVQNVDFVKSVEAA-GAINKWVEDQTNNRIKNLVDPD 156 Query: 180 DVKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEK 239 + TTR +LVNAIYFK W+ KF E+T + F +SK+K+ V M + + + Sbjct: 157 ALDETTRSVLVNAIYFKGSWKDKFNKERTMDRDFHVSKDKTIKVPTMIGKKDVRYADVPE 216 Query: 240 MNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLEREL-TYERLSEWADSKMMTETLVD 298 ++ KMIE+ Y + SM I+LP+ + G+ LE++L + LS + + T V+ Sbjct: 217 LDAKMIEMSYEGDQASMIIILPNQVD----GITALEQKLKDPKALSR--AEERLYNTEVE 270 Query: 299 LHLPKFSLEDRIDLRDTLRNMGMTTAFTTNADF--RGMTDKKDLAISKVIHQSFVAVDEK 356 ++LPKF +E DL++ L NM + FT A + K+ L + I ++F+ V Sbjct: 271 IYLPKFKIETTTDLKEVLSNMNIKKLFTPGAARLENLLKTKESLYVDAAIQKAFIEV--N 328 Query: 357 GTEAAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 A AA A TT + V K +++ PF F +++N++ F G P Sbjct: 329 EEGAEAAAANAFKITTYSFHFVPKVEINKPFFFSLKYNRNSM--FSGVCVQP 378 >1K9O-I nrPDB Length = 378 Score = 305 bits (780), Expect = 3e-83, Method: Composition-based stats. Identities = 114/412 (27%), Positives = 196/412 (47%), Gaps = 44/412 (10%) Query: 1 MEQVSASIGN-FTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLH 59 ++++ + FT +F+++ + N +N+ S +S+ L LA+ G + E+ L Sbjct: 7 LQKILRESNDQFTAQMFSEVVKANPGQNVVLSAFSVLPPLGQLALASVGESHDELLRALA 66 Query: 60 FTEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANR 119 + F +L + L+ A++ Sbjct: 67 LPNDNVTKDV----------------------------FADLNRGV-RAVKGVDLKMASK 97 Query: 120 IYVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSD 179 IYV K L + +S+ + +E Q V+F + E + IN WVE QT ++IKNL+ D Sbjct: 98 IYVAKGLELNDDFAAVSRDVFGSEVQNVDFVKSVEAA-GAINKWVEDQTNNRIKNLVDPD 156 Query: 180 DVKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEK 239 + TTR +LVNAIYFK W+ KF E+T + F +SK+K+ V M + + + Sbjct: 157 ALDETTRSVLVNAIYFKGSWKDKFVKERTMDRDFHVSKDKTIKVPTMIGKKDVRYADVPE 216 Query: 240 MNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLEREL-TYERLSEWADSKMMTETLVD 298 ++ KMIE+ Y + SM I+LP+ + G+ LE++L + LS + + T V+ Sbjct: 217 LDAKMIEMSYEGDQASMIIILPNQVD----GITALEQKLKDPKALSR--AEERLYNTEVE 270 Query: 299 LHLPKFSLEDRIDLRDTLRNMGMTTAFTTNADF--RGMTDKKDLAISKVIHQSFVAVDEK 356 + LPKF +E DL++ L NM + FT A + K+ L + I ++F+ V+E+ Sbjct: 271 ITLPKFKIETTTDLKEVLSNMNIKKLFTPGAARLENLLKTKESLTVDAAIQKAFIEVNEE 330 Query: 357 GTEAAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 G EAAAA A I + ++ + +D PF+F ++ +F G+ P Sbjct: 331 GAEAAAANAFGIVPKSLILY--PEVHIDRPFYFELK--IDGIPMFNGKVIEP 378 >3PZF-A nrPDB Length = 397 Score = 301 bits (771), Expect = 3e-82, Method: Composition-based stats. Identities = 92/405 (22%), Positives = 180/405 (44%), Gaps = 35/405 (8%) Query: 9 GNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAES 68 F + ++ + N + N+ SP+S+ L L Y A Sbjct: 23 NEFDLMFVKEIFK-NHNSNVVLSPFSVKILLTLIY---------------------EASD 60 Query: 69 SSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYAL 128 +S + +++ ++ S +K+LL + + +Y L A +V+ + Sbjct: 61 TSFGNAVSNTKRELSSVIQNDNIDHTRSYYKQLLESAQQDNKDYDLNIATNFFVDDFIEV 120 Query: 129 LPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLI 188 + Y Q++ +Y A +KV++ + P Q+ IN WV + T +++ +++ D ++ + Sbjct: 121 INKYQQIANTHYHAMLEKVSY-SNPTQTAATINNWVSEHTNGRLREIVTPDSLEG-AVIT 178 Query: 189 LVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELP 248 LVN IYFK W F +++PF ++ K + M F + +++ LP Sbjct: 179 LVNVIYFKGLWTYPFPEVANNVKPFYGTRGKPTNAQYMEQNGQFYYDNSADLGAQILRLP 238 Query: 249 YVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLED 308 Y +L+M+ +LP+ L+++ ++ L W M E V++ LPKF + Sbjct: 239 YRGNKLAMYFILPNPDNTVNQVLDRINSASLHQAL--W----YMEENEVNVTLPKFKFDF 292 Query: 309 RIDLRDTLRNMGMTTAFTTNADFR----GMTDKKDLAISKVIHQSFVAVDEKGTEAAAAT 364 L + L+ +G+ F+ NA G + ++ +S++ ++ + ++E G+EA AAT Sbjct: 293 SEQLNEPLQQVGIREIFSQNASLPLLARGRGARDEVRVSRIFQKAGITINELGSEAYAAT 352 Query: 365 AVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 + + + V F + PF FFI T+LF G+ PV Sbjct: 353 EIQLVNKFG-GDGVQIFNANRPFIFFIEDETLGTMLFAGKIENPV 396 >3STO-A nrPDB Length = 406 Score = 288 bits (736), Expect = 4e-78, Method: Composition-based stats. Identities = 96/402 (23%), Positives = 172/402 (42%), Gaps = 23/402 (5%) Query: 11 FTVDLFNKLNETNRDKNIFFSPWSISSALALT--YLAAKGSTAREMAEVLHFTEAVRAES 68 FT + + N P I L + A+G T ++ + + + + Sbjct: 22 FTHAYLSTVTADFGGDNFLTCPLGILFTLGILLGSGGAQGRTGYQIGKTMRLKSTSSSWN 81 Query: 69 SSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYAL 128 SS A+ + +++ T N+ N +R + I+VEKTY + Sbjct: 82 SSEAQQEM-----------KSLYQELNNSLTSEKTFLNEKEENV-VRISTGIFVEKTYEV 129 Query: 129 LPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLI 188 + + + E ++V+F + IN WV++Q+ ++ + DD+ T +I Sbjct: 130 ERRFNESIANDSEGELKQVDFSNRTSATVD-INDWVDQQSNGLLEKFFT-DDIPDDTAMI 187 Query: 189 LVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELP 248 LVN YF+ W+ F+ T + F +S ++ V MM E F+++ P Sbjct: 188 LVNVFYFRDFWQSPFEPHYTRKEDFYISPDRQITVDMMTQEGVMKYGKFEDEGFEIVSKP 247 Query: 249 YVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLED 308 + I+LP + E L + LSE+ K + ET V L LPKF+L++ Sbjct: 248 LNNTRFTFVIVLPLEKWSLNGATELLNGN---KVLSEYV--KNLKETTVSLRLPKFTLKN 302 Query: 309 RIDLRDTLRNMGMTTAFTT-NADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVI 367 +DL TL+++G+ F +D G+T +L +++ I + + ++E G EA T+ I Sbjct: 303 TLDLVPTLKSIGVVDLFDPVKSDLSGITPNPNLYVNEFIQTNVLKLNESGIEATTVTSPI 362 Query: 368 ISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 +++I V F V HPF FI + + + PV Sbjct: 363 FVPFSAIIPEV-DFHVTHPFICFIYDQQLTMPIMAAKVMNPV 403 >1JJO-C nrPDB Length = 261 Score = 285 bits (730), Expect = 2e-77, Method: Composition-based stats. Identities = 88/265 (33%), Positives = 147/265 (55%), Gaps = 13/265 (4%) Query: 109 RNNYSLRSANRIYVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQT 168 N Y ++ AN ++V+ + + +LQ+ K Y+ AE V+F + IN WVE T Sbjct: 1 ENQYVMKLANSLFVQNGFHVNEEFLQMLKMYFNAEVNHVDFSQNVAVANS-INKWVENYT 59 Query: 169 ESKIKNLLSSDDVKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYM 228 S +K+L+S +D T L L+NA+YFK W+ +F+ E T F + MMY Sbjct: 60 NSLLKDLVSPEDFDGVTNLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQ 119 Query: 229 RDTFPVLIMEKMN------FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYER 282 + F + ++++E+PY E+SM + L L LE L + Sbjct: 120 QGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLALSRQ----EVPLATLEPLLKAQL 175 Query: 283 LSEWADSKMMTETLVDLHLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAI 342 + EWA+S + + V+++LP+F++E IDL+D L+ +G+T F +A+ M+DKK+L + Sbjct: 176 IEEWANS--VKKQKVEVYLPRFTVEQEIDLKDILKALGVTEIFIKDANLTAMSDKKELFL 233 Query: 343 SKVIHQSFVAVDEKGTEAAAATAVI 367 SK +H+S + V+E+G+EAAAA+ +I Sbjct: 234 SKAVHKSCIEVNEEGSEAAAASGMI 258 >1SNG-A nrPDB Length = 370 Score = 284 bits (727), Expect = 4e-77, Method: Composition-based stats. Identities = 100/401 (24%), Positives = 157/401 (39%), Gaps = 55/401 (13%) Query: 10 NFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESS 69 F + L +L E D + +SP+S++ AL + A+ Sbjct: 16 EFALHLHRRLAEAVPDGEVIWSPYSVACALGVLAAGARA--------------------- 54 Query: 70 SVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKP-RNNYSLRSANRIYVEKTYAL 128 DP LL A ++ ++ L S ++V + Sbjct: 55 ---TTRTELTTLLGTDP------------APLLAALDRAVTDSPDLASRTVLWVSADVPV 99 Query: 129 LPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLI 188 ++ ++ + +F+T PE R +N + T I+ LL V R I Sbjct: 100 RSSFRATMHDRPDSDVRTADFRTNPEGVRATVNADIADATRGMIRELLPQGAVTPDLRAI 159 Query: 189 LVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELP 248 L NA++ KA W F+A T FR + K V M+ T P ++M+ L Sbjct: 160 LTNALWAKARWTTPFEAHLTRAGTFRTPRGP-KRVPFMHRTKTMPYATAR--GWRMVTL- 215 Query: 249 YVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLED 308 + EL++ +LLP L L + T V+L LP+F L Sbjct: 216 HAHDELAVDVLLPPGTNAAAVPTAPLLTAL----------HRRSASTSVELALPRFELTQ 265 Query: 309 RIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVII 368 L + L G+ T FT +AD G++ L + VIHQ+ + VDE+G E AAATA ++ Sbjct: 266 PHQLVEVLAEAGVRTLFTASADLSGISTVP-LYVDTVIHQARLRVDERGAEGAAATAAMM 324 Query: 369 SFTTS-VINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 + ++F VD PFH +R + ILF G P Sbjct: 325 LLAGAMPPRRTIRFSVDRPFHIVVR--RRGAILFLGSIADP 363 >2OAY-A nrPDB Length = 390 Score = 276 bits (706), Expect = 1e-74, Method: Composition-based stats. Identities = 98/407 (24%), Positives = 177/407 (43%), Gaps = 52/407 (12%) Query: 4 VSASIGNFTVDLFNKLNETNR-DKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTE 62 + ++ +F++ L++ + + + N+ FSP+SI+S L L A +T + +L + + Sbjct: 32 LGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPK 91 Query: 63 AVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYV 122 +H K T + S ++I+ Sbjct: 92 DFTC---------------------------VHQALKGFTTK--------GVTSVSQIFH 116 Query: 123 EKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVK 182 A+ T++ S+ Y + P+ + + + + INTWV K T +KI LL D + Sbjct: 117 SPDLAIRDTFVNASRTLYSSSPRVL--SNNSDANLELINTWVAKNTNNKISRLL--DSLP 172 Query: 183 ATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRD-TFPVLIMEKMN 241 + TRL+L+NAIY A+W+ F +KT ++PF KN V MM + I + + Sbjct: 173 SDTRLVLLNAIYLSAKWKTTFDPKKTRMEPFHF-KNSVIKVPMMNSKKYPVAHFIDQTLK 231 Query: 242 FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHL 301 K+ +L LS+ IL+P ++K +EQ ++ + E + TL L L Sbjct: 232 AKVGQLQLSHN-LSLVILVPQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTL--LTL 288 Query: 302 PKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAA 361 P+ + D+ + + F+ + + G+T+ DL +S + HQ+ + + E G E Sbjct: 289 PRIKVTTSQDMLSIMEKLEFFD-FSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVE-- 345 Query: 362 AATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCP 408 + SV +L F+V PF F + + K +F GR P Sbjct: 346 ----AAAASAISVARTLLVFEVQQPFLFMLWDQQHKFPVFMGRVYDP 388 >2PEF-A nrPDB Length = 373 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 107/410 (26%), Positives = 185/410 (45%), Gaps = 49/410 (11%) Query: 2 EQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFT 61 E+ + +F+++LF N + +N SP S ALA+T A T +M + L Sbjct: 7 EKFIYNTADFSIELFK--NSIDDKENSLISPLSAMLALAMTANGADNETLAQMEKALG-- 62 Query: 62 EAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIY 121 + S+ ++ + P E+++ L AN I+ Sbjct: 63 -----KDISIEDLNKYLYTYMKKLPNEEKSK---------------------LTIANSIW 96 Query: 122 VEK-TYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD 180 ++ + +LQ+ YYKA+ K F ++ + +IN WV+ +T I +L+ Sbjct: 97 FKENDFMPSKDFLQIIADYYKADIFKAAFDSS---TVSDINNWVKSKTNGMIDKILNK-- 151 Query: 181 VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKM 240 + + L+NA+ F AEWE ++ F + V+ M + + I E+ Sbjct: 152 IDPEDVMYLINAVAFDAEWETVYEKASVHEDIFTDVYGNRQKVEFMNSEE--NLYIEEEN 209 Query: 241 NFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLH 300 ++ PY K S +LPD+ + + + LT ++ + + +T LV Sbjct: 210 AVGFVK-PYAKNHYSFVAILPDE----NISVNEYIKTLTGQKFIDLIKNAKIT--LVRAS 262 Query: 301 LPKFSLEDRIDLRDTLRNMGMTTAFTTN-ADFR--GMTDKKDLAISKVIHQSFVAVDEKG 357 LPKF E I + +TL ++GMT AF + ADF G +D +L IS+V+H++F++VDE G Sbjct: 263 LPKFKYEYTIKMNETLESLGMTDAFLPDKADFSKLGKSDIGNLYISEVLHKTFISVDELG 322 Query: 358 TEAAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCC 407 T+A A T+V I+ +N K++ PF F I N + +F G Sbjct: 323 TKAGAVTSVDITAAGIPVNF-KTVKLNRPFIFAIIDNSTNLPIFIGTVLS 371 >1C8O-A nrPDB Length = 300 Score = 270 bits (690), Expect = 8e-73, Method: Composition-based stats. Identities = 104/358 (29%), Positives = 180/358 (50%), Gaps = 61/358 (17%) Query: 13 VDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSSVA 72 +D+F ++ + + +N+F SP SISS L + Y A GSTA +++ Sbjct: 1 MDIFREIASSMKGENVFISPPSISSVLTILYYGANGSTAEQLS----------------- 43 Query: 73 RPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTY 132 K + +K +++ S +S N++Y + ++ Sbjct: 44 --------------------------KYVEKEADKNKDDISFKSMNKVYGRYSAVFKDSF 77 Query: 133 LQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILVNA 192 L+ ++ V+F + ++ IN V+ TE KI LL + + T L+ ++A Sbjct: 78 LRKIGDNFQT----VDFTDS--RTVDAINKSVDIFTEGKINPLLD-EPLSPDTSLLAISA 130 Query: 193 IYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDT-FPVLIMEK--MNFKMIELPY 249 +YFKA+W + F+ E TS PF +S + V MM M F +++ NF +IELPY Sbjct: 131 VYFKAKWLMPFEKEFTSDYPFYVSPTEMVDVSMMSMYGEAFNHASVKESFGNFSIIELPY 190 Query: 250 VKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDR 309 V SM ++LPD+I GLE +E+ LT +W+DS M +D+H+PKF + Sbjct: 191 VGD-TSMVVILPDNID----GLESIEQNLTDTNFKKWSDS--MDAMFIDVHIPKFKVTGS 243 Query: 310 IDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVI 367 +L D L +G+T F + D+ M++ D+++ +IH++++ V+E+ TEAAAAT+ + Sbjct: 244 YNLVDALVKLGLTEVFGSTGDYSNMSNS-DVSVDAMIHKTYIDVNEEYTEAAAATSAL 300 >1MTP-A nrPDB Length = 323 Score = 254 bits (650), Expect = 4e-68, Method: Composition-based stats. Identities = 81/348 (23%), Positives = 131/348 (37%), Gaps = 52/348 (14%) Query: 10 NFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESS 69 F + L +L E D + +SP+S++ AL + A+ Sbjct: 12 EFALHLHRRLAEAVPDGEVIWSPYSVACALGVLAAGARA--------------------- 50 Query: 70 SVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKP-RNNYSLRSANRIYVEKTYAL 128 DP LL A ++ ++ L S ++V + Sbjct: 51 ---TTRTELTTLLGTDP------------APLLAALDRAVTDSPDLASRTVLWVSADVPV 95 Query: 129 LPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLI 188 ++ ++ + +F+T PE R +N + T I+ LL V R I Sbjct: 96 RSSFRATMHDRPDSDVRTADFRTNPEGVRATVNADIADATRGMIRELLPQGAVTPDLRAI 155 Query: 189 LVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELP 248 L NA++ KA W F+A T FR + K V M+ T P ++M+ L Sbjct: 156 LTNALWAKARWTTPFEAHLTREGTFRTPRGP-KRVPFMHRTKTMPYATAR--GWRMVTL- 211 Query: 249 YVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLED 308 + EL++ +LLP L L + T V+L LP+F L Sbjct: 212 HAHDELAVDVLLPPGTNAAAVPTAPLLTAL----------HRRSASTSVELALPRFELTQ 261 Query: 309 RIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEK 356 L + L G+ T FT +AD G++ L + VIHQ+ + VDE+ Sbjct: 262 PHQLVEVLAEAGVRTLFTASADLSGISTVP-LYVDTVIHQARLRVDER 308 >5C98-A nrPDB Length = 382 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 76/409 (18%), Positives = 160/409 (39%), Gaps = 54/409 (13%) Query: 2 EQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFT 61 + + A+ FT++ F + N SP+ + AL++ Y A + + Sbjct: 15 DAIVAANNKFTLEYFKAC--YDEKCNCAVSPYHVRLALSMFYPLAGAAVQEDFQVAFGLP 72 Query: 62 EAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIY 121 E V A ++ + A+ +H + L++ + + Sbjct: 73 EDVHAA----------------IEQQQRLAQQLH--------------DGQHLKALSFVL 102 Query: 122 VEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDD- 180 VE+T L + +L + ++ + V+ + +N++ ++ ++I++ + D Sbjct: 103 VEETLRLDSEFERLFHRTFQTTVEPVDLTDDIPSAL-AVNSFYQRA-NTEIEDFIGEGDV 160 Query: 181 --VKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIME 238 + +L+L + + ++F T+++ F+ ++ V M+ + Sbjct: 161 FSLPPCHKLMLFSGVSVLTPLAIRFNPADTALELFQFINAPTQRVSTMHTTAFVRRCLHN 220 Query: 239 KMNFKMIELPY-VKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLV 297 ++ K++++P+ LSM +LLP D T L Q+ +T L++ + + Sbjct: 221 ELRCKVVDMPFDAASGLSMLVLLPYDG----TELRQIVNSITPAHLAQI--DERLQSCWT 274 Query: 298 DLHLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKG 357 DL LPKF + ++ D + TL +G F + D D ++ I ++AV E G Sbjct: 275 DLKLPKFFVREKTDPKQTLGKLGYGGVFEID-DLHVFHDSGRTRLNGFIQHCYLAVSESG 333 Query: 358 TEAAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFC 406 + A F +F + PF F IR +L G F Sbjct: 334 SGIPAPPDTPSEF---------EFHANRPFMFLIRRTMDGNVLQVGNFS 373 >6BJ5-B nrPDB Length = 315 Score = 238 bits (607), Expect = 3e-63, Method: Composition-based stats. Identities = 87/348 (25%), Positives = 159/348 (45%), Gaps = 63/348 (18%) Query: 22 TNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSSVARPSRGRPKR 81 N N+ FSP+ ++SAL++ +AA G+T RE+ E+V +S + Sbjct: 27 YNESDNVVFSPYGLTSALSVLRIAAGGNTKREID----VPESVVEDSDAFLALRE----- 77 Query: 82 RRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTYLQLSKKYYK 141 ++V+ + L P + + Sbjct: 78 --------------------------------------LFVDASVPLRPEFTAEFSSRFN 99 Query: 142 AEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILVNAIYFKAEWEV 201 Q+V F + E + IN++V+ +T + +L + + T+++L++++ K W Sbjct: 100 TSVQRVTFNS--ENVKDVINSYVKDKTGGDVPRVLDA-SLDRDTKMLLLSSVRMKTSWRH 156 Query: 202 KFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPV--LIMEKMNFKMIELPYVKRELSMFIL 259 F T+ QPF S N + V+MM DT + + + + ELPY +R+ +M ++ Sbjct: 157 VFDPSFTTDQPFY-SGNVTYKVRMMNKIDTLKTETFTLRNVGYSVTELPYKRRQTAMLLV 215 Query: 260 LPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDRIDLRDTLRNM 319 +PDD L ++ R L + W + M + + + +PKFS+E +DLRD L+ + Sbjct: 216 VPDD-------LGEIVRALDLSLVRFWI--RNMRKDVCQVVMPKFSVESVLDLRDALQRL 266 Query: 320 GMTTAFTTN-ADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAV 366 G+ AF + ADF + DL ++KV+ S + DE+GT A++ TA+ Sbjct: 267 GVRDAFDPSRADFGQASPSNDLYVTKVLQTSKIEADERGTTASSDTAI 314 >1M93-B nrPDB Length = 245 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 85/260 (32%), Positives = 145/260 (55%), Gaps = 18/260 (6%) Query: 111 NYSLRSANRIYVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTES 170 + S +S N++Y + ++L+ ++ V+F + ++ IN V+ TE Sbjct: 1 DISFKSMNKVYGRYSAVFKDSFLRKIGDNFQT----VDFTDS--RTVDAINKSVDIFTEG 54 Query: 171 KIKNLLSSDDVKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRD 230 KI LL + + T L+ ++A+YFKA+W + F+ E TS PF +S + V MM M Sbjct: 55 KINPLLD-EPLSPDTSLLAISAVYFKAKWLMPFEKEFTSDYPFYVSPTEMVDVSMMSMYG 113 Query: 231 T-FPVLIMEK--MNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWA 287 F +++ NF +IELPYV SM ++LPD+I GLE +E+ LT +W+ Sbjct: 114 EAFNHASVKESFGNFSIIELPYVGD-TSMVVILPDNID----GLESIEQNLTDTNFKKWS 168 Query: 288 DSKMMTETLVDLHLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIH 347 DS M +D+H+PKF + +L D L +G+T F + D+ M++ D+++ +IH Sbjct: 169 DS--MDAMFIDVHIPKFKVTGSYNLVDALVKLGLTEVFGSTGDYSNMSNS-DVSVDAMIH 225 Query: 348 QSFVAVDEKGTEAAAATAVI 367 ++++ V+E+ TEAAAAT+ + Sbjct: 226 KTYIDVNEEYTEAAAATSAL 245 >2WXZ-C nrPDB Length = 453 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 72/414 (17%), Positives = 146/414 (35%), Gaps = 45/414 (10%) Query: 5 SASIGNF-TVDLFNKLNETNR-DKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTE 62 A I NF ++ L+E SP ++ L YL + TA ++ +L Sbjct: 73 VAMIANFMGFRMYKMLSEARGVASGAVLSPPALFGTLVSFYLGSLDPTASQLQVLLGVPV 132 Query: 63 AVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSL--RSANRI 120 +S + + LL + L + + Sbjct: 133 KEGDCTSRLDGHKVLTAL---------------QAVQGLLVTQGGSSSQTPLLQSTVVGL 177 Query: 121 YVEKTYALLPTYLQLSKKYYKAE-PQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSD 179 + L +++ + A P+ ++ T P + ++IN +V+ T K+ L + Sbjct: 178 FTAPGLRLKQPFVESLGPFTPAIFPRSLDLSTDPVLAAQKINRFVQAVTGWKMN--LPLE 235 Query: 180 DVKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEK 239 V + L ++F+ + F + T + F + + S V M+ F + Sbjct: 236 GVSTDSTLFFNTYVHFQGK-MRGFS-QLTGLHEFWVDNSTSVSVPMLSGTGNFQHWSDAQ 293 Query: 240 MNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDL 299 NF + +P + +++ ++ P + L+++E + W + + L Sbjct: 294 NNFSVTRVP-LGESVTLLLIQPQ----CASDLDRVEVLVFQHDFLTWIKNP--PPRAIRL 346 Query: 300 HLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAV----DE 355 LP+ + +L+D L ++T A+ M D + +V++ + + +E Sbjct: 347 TLPQLEIRGSYNLQDLLAQAKLSTLLGAEANLGKMGDTNP-RVGEVLNSILLELQAGEEE 405 Query: 356 KGTEAAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 + TE+A VL + PF F I S + F GR P Sbjct: 406 QPTESAQQPGSP---------EVLDVTLSSPFLFAIYERDSGALHFLGRVDNPQ 450 >2WXX-A nrPDB Length = 453 Score = 140 bits (354), Expect = 8e-34, Method: Composition-based stats. Identities = 72/411 (17%), Positives = 144/411 (35%), Gaps = 39/411 (9%) Query: 5 SASIGNF-TVDLFNKLNETNRDKN-IFFSPWSISSALALTYLAAKGSTAREMAEVLHFTE 62 A I NF ++ LNE + SP ++ L YL + TA ++ +L Sbjct: 73 VAMITNFVGFRMYKMLNEAGSGASGAILSPPALFGTLVSFYLGSLDPTASQLQTLLDVPV 132 Query: 63 AVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSL--RSANRI 120 +S + + LL + L + Sbjct: 133 KEGDCTSRLDGHKVLAAL---------------RAVQGLLVTQGGSSSQTPLLQSIVVGL 177 Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQK--VNFKTAPEQSRKEINTWVEKQTESKIKNLLSS 178 + + L +++Q + ++ T P + ++IN +++ T K+ L Sbjct: 178 FTAPGFRLKHSFVQSLA-LFTPALFPRSLDLSTDPVLATEKINRFIKAVTGWKMN--LPL 234 Query: 179 DDVKATTRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIME 238 + V + L+ ++F+ F + + F + + S V M+ F Sbjct: 235 EGVSTDSTLLFNTYVHFQGT-MRGFS-QLPGVHEFWVDNSISVSVPMISGTGNFQHWSDA 292 Query: 239 KMNFKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVD 298 + NF + +P + ++ ++ P I D L+++E + L W ++ + Sbjct: 293 QNNFSVTCVP-LGERATLLLIQPHCISD----LDRVEALIFQNDLLTWIENP--PPRAIR 345 Query: 299 LHLPKFSLEDRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGT 358 L LP+ + +L+D L + T A+ + D + +V++ + + + G Sbjct: 346 LTLPQLEIRGSYNLQDLLAEDKLPTLLGAEANLNNIGDTNP-RVGEVLNSILLEL-KAGE 403 Query: 359 EAAAATAVIISFTTSVINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCCPV 409 E T+V L + PF F I S T+ F GR P Sbjct: 404 EEQPTTSV----QQPGSPEALDVTLSSPFLFAIYEQDSGTLHFLGRVNNPQ 450 >5M3Y-A nrPDB Length = 458 Score = 134 bits (336), Expect = 9e-32, Method: Composition-based stats. Identities = 67/384 (17%), Positives = 146/384 (38%), Gaps = 37/384 (9%) Query: 29 FFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSSVARPSRGRPKRRRMDPEH 88 SP ++ LA YL A TA + +L + K+ + Sbjct: 100 VLSPTAVFGTLASLYLGALDHTADRLQAILGVP---------------WKDKQCTSRLDA 144 Query: 89 EQAENIHSGFKELLTAFNKPRNNYSLRSAN--RIYVEKTYALLPTYLQLSKKY-YKAEPQ 145 + + + LL A + + L + ++ L ++Q Y P+ Sbjct: 145 HKVLSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPR 204 Query: 146 KVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILVNAIYFKAEWEVKFQA 205 ++F T + + ++I+ +++ T K + L V +T L ++F+ + F Sbjct: 205 SLDF-TELDVAAEKIDRFMQAVTGWKTGSSLMGASVDST--LAFNTYVHFQGK-MKGFSL 260 Query: 206 EKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPYVKRELSMFILLPDDIK 265 Q F + ++ S V M+ TF + F + ++P+ S+ ++ P Sbjct: 261 -LAEPQEFWVDQSTSVSVPMLSGMGTFQHWSDIQDQFSVTQVPFT-ESASLLLIQPHYAS 318 Query: 266 DGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDRIDLRDTLRNMGMTTAF 325 D L+++E + W K ++ + L +P+ L+ DL+D L + Sbjct: 319 D----LDKVEGLTFQQNSLNWM--KKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAIL 372 Query: 326 TTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVIISFTTSVINHVLKFKVDH 385 T + + +++ + + + +V++ F ++ E +T VL+ ++ Sbjct: 373 HTELNLQKLSNDR-IRVGEVLNSIFFELEADEREPTEST------QQLNKPEVLEVTLNR 425 Query: 386 PFHFFIRHNKSKTILFFGRFCCPV 409 PF F + + + F GR P+ Sbjct: 426 PFLFAVYDQSATALHFLGRVANPL 449 >4R9I-A nrPDB Length = 378 Score = 83.2 bits (204), Expect = 2e-16, Method: Composition-based stats. Identities = 59/394 (14%), Positives = 122/394 (30%), Gaps = 56/394 (14%) Query: 21 ETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSSVARPSRGRPK 80 + ++N F + + + L+ L +K T E+ + L+ Sbjct: 34 QYEPERNQFSTAFPLLFMLSELSLNSKEDTTAELYKNLNL-------------------- 73 Query: 81 RRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTYLQLSKKYY 140 + + + + + T N Y Y + T++Q K + Sbjct: 74 --------RSEDEVVNVNQAVNTNLNTKNEVYQSTLILNAYTDIDSPFSETFIQNFAKVF 125 Query: 141 KAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLILVNA--IYFKAE 198 + +++ + I ++ + + I+ L D+ T +IL IYF Sbjct: 126 NGTVKNIDYSND---AVATIRDSLQSDSGNDIEIALKDGDINKDTGIILTAYTNIYF--P 180 Query: 199 W---EVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMNFKMIELPYVKRELS 255 W ++ K F + Y +E + K+ + Sbjct: 181 WGEASDSYRPYKQIDISFTALDGTQSNKQAWYSEGAGKYAEIENLGIKVFQFSLKPG--- 237 Query: 256 MFILLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDRIDLRDT 315 + ++L + D + L+ + + + + ++ D D Sbjct: 238 LTVVLGTSLNDNNDLSGAFNKLRDPATLAYILTQTESKYLKLAVPI-ELTMRDSRDYIPE 296 Query: 316 LRNMGM-TTAFTTNAD-FRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVIISFTTS 373 ++ G+ T F N D F + D K IS ++ + + E+ TE AA+ V Sbjct: 297 VKRAGLLTELFEKNFDGFDTVYDNKSGYISYMLSHTRLEF-EQPTEEQAASVVA------ 349 Query: 374 VINHVLKFKVDHPFHFFIRHNKSKTILFFGRFCC 407 F D P+ F + T F G Sbjct: 350 ----EPDFIFDKPYFFLVLDQF-NTPAFIGLITN 378 >5NSQ-A nrPDB Length = 521 Score = 33.5 bits (75), Expect = 0.17, Method: Composition-based stats. Identities = 17/71 (23%), Positives = 30/71 (42%), Gaps = 14/71 (19%) Query: 325 FTTNA--DFRGMTDKKDLAISKVIHQSFVAVDEKGTEAA--------AATAVIISFTTSV 374 FT + D +T + +A + H + + V+E+G EAA T + + Sbjct: 391 FTPDVVIDMATLTGAQGIATGR--HHAGLYVNEEGAEAAMLRAGRESGETCFPVLYCPEY 448 Query: 375 INHVLKFKVDH 385 H +FK +H Sbjct: 449 --HEPEFKSNH 457 >4P2L-A nrPDB Length = 506 Score = 31.9 bits (71), Expect = 0.47, Method: Composition-based stats. Identities = 13/50 (26%), Positives = 22/50 (44%), Gaps = 7/50 (14%) Query: 124 KTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIK 173 + L ++ + KY+ +P NF IN W++KQ + KI Sbjct: 285 QRLVALKKFVAVLAKYFPGQPLVQNF-------LHSINDWLQKQQKKKIP 327 >1F2V-A nrPDB Length = 219 Score = 31.5 bits (70), Expect = 0.68, Method: Composition-based stats. Identities = 10/46 (21%), Positives = 17/46 (36%) Query: 1 MEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAA 46 + + S + V + + + FSP +SSA A A Sbjct: 36 LSRFSEEEADLAVRMVHACGSVEATRQFVFSPDFVSSARAALKAGA 81 >3T59-A nrPDB Length = 519 Score = 31.5 bits (70), Expect = 0.70, Method: Composition-based stats. Identities = 12/60 (20%), Positives = 24/60 (40%), Gaps = 7/60 (11%) Query: 124 KTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKA 183 + L ++ + KY+ +P NF IN W++KQ + +I + + Sbjct: 297 QRLVALKKFVAVLAKYFPGQPLVQNF-------LHSINDWLQKQQKKRIPYSFFKAALDS 349 >3LLI-A nrPDB Length = 261 Score = 31.2 bits (69), Expect = 0.79, Method: Composition-based stats. Identities = 11/60 (18%), Positives = 22/60 (36%), Gaps = 7/60 (11%) Query: 124 KTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKA 183 + L ++ + KY+ P NF +N W+++Q +KI + Sbjct: 40 QRLVALKKFVAVLAKYFPGRPLVQNF-------LHSVNEWLKRQKRNKIPYSFFKTALDD 92 >2P6F-A nrPDB Length = 455 Score = 31.2 bits (69), Expect = 0.90, Method: Composition-based stats. Identities = 16/103 (15%), Positives = 44/103 (42%), Gaps = 15/103 (14%) Query: 122 VEKTYALLPTYLQLSK--KYYKAEPQKVNF--KTAPEQSRKEINTWVEKQTESKIKNLLS 177 +++ + L Y + + + E + NF + + ++ I ++V +Q + KI + S Sbjct: 269 IDQVFELFKRYQSRFELIQIFTKEEFEHNFIGEESLPLDKQVIFSYVVEQPDGKITDFFS 328 Query: 178 SDDVK----ATTRL--ILVNAIYFKA-----EWEVKFQAEKTS 209 + T+ + + +Y+ A +++ +F + T Sbjct: 329 FYSLPFTILNNTKYKDLGIGYLYYYATDADFQFKDRFDPKATK 371 >4B8O-A nrPDB Length = 490 Score = 30.4 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 19/164 (11%), Positives = 44/164 (26%), Gaps = 10/164 (6%) Query: 33 WSISSALALTYLAAKGSTAREMAEV---LHFTEAVRAESSSVARPSRGRPKRRRMDPEHE 89 + + AL +T + + + + P+ Sbjct: 98 FEAAWALTNIASGTSENTKVVIDHGAVPIFVKLLGSSSDDVREQAVWALGNVAGDSPKCR 157 Query: 90 QAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTY---ALLPTYLQLSKKYYK-AEPQ 145 + LL N+ LR N + + P++ Q A Sbjct: 158 DLVLANGALLPLLAQLNEHTKLSMLR--NATWTLSNFCRGKPQPSFEQTRPALPALARLI 215 Query: 146 KVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLIL 189 N + + + +++ T KI+ ++ + L+L Sbjct: 216 HSNDEEVLTDACWAL-SYLSDGTNDKIQAVIEAGVCPRLVELLL 258 >4B8J-A nrPDB Length = 528 Score = 30.4 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 19/164 (11%), Positives = 44/164 (26%), Gaps = 10/164 (6%) Query: 33 WSISSALALTYLAAKGSTAREMAEV---LHFTEAVRAESSSVARPSRGRPKRRRMDPEHE 89 + + AL +T + + + + P+ Sbjct: 136 FEAAWALTNIASGTSENTKVVIDHGAVPIFVKLLGSSSDDVREQAVWALGNVAGDSPKCR 195 Query: 90 QAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTY---ALLPTYLQLSKKYYK-AEPQ 145 + LL N+ LR N + + P++ Q A Sbjct: 196 DLVLANGALLPLLAQLNEHTKLSMLR--NATWTLSNFCRGKPQPSFEQTRPALPALARLI 253 Query: 146 KVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKATTRLIL 189 N + + + +++ T KI+ ++ + L+L Sbjct: 254 HSNDEEVLTDACWAL-SYLSDGTNDKIQAVIEAGVCPRLVELLL 296 >2ILV-A nrPDB Length = 400 Score = 30.0 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 24/55 (43%), Gaps = 3/55 (5%) Query: 121 YVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIKNL 175 Y ++ LL + Q + + K+ FK P EIN ++ ++ I N+ Sbjct: 257 YAQQQLNLLNHFTQAEGDLFIGDHYKIYFKGHPRG--GEINDYILNNAKN-ITNI 308 >5D9K-A nrPDB Length = 330 Score = 29.6 bits (65), Expect = 2.7, Method: Composition-based stats. Identities = 13/82 (15%), Positives = 28/82 (34%), Gaps = 16/82 (19%) Query: 308 DRIDLRDTLRNMGMTTAFTTNADFRGMTDKKDLAISKVIHQSFVAVDEKGTEAAAATAVI 367 + +L L F G +D + L KV+ ++ + V ++ Sbjct: 30 SQFELLKVLGQGSFGKVFLVK-KISG-SDARQLYAMKVLKKATLKVRDR----------- 76 Query: 368 ISFTTSVINHVLKFKVDHPFHF 389 + + + +V+HPF Sbjct: 77 ---VRTKMERDILVEVNHPFIV 95 >1PD0-A nrPDB Length = 810 Score = 29.6 bits (65), Expect = 2.7, Method: Composition-based stats. Identities = 23/172 (13%), Positives = 61/172 (35%), Gaps = 14/172 (8%) Query: 6 ASIGNFT---VDLFNKLNETNRDKNIFFS---PWSISSALAL-TYLAAKGSTAREMAEVL 58 +++ FT + + N + + FS IS + T + A+GST M+ Sbjct: 397 SNLSRFTAGQTHFYPGFSGKNPNDIVKFSTEFAKHISMDFCMETVMRARGSTGLRMSRFY 456 Query: 59 HFTEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSAN 118 ++ + + R + ++ + + + ++ + + +R Sbjct: 457 GHFFNRSSDLCAFSTMPRDQSYLFEVNVDESIMAD--YCYVQVAVLLSLNNSQRRIRIIT 514 Query: 119 RIYVEKTYALLPTYLQL----SKKYYKAEPQKVNFKTAPEQSRKEINTWVEK 166 + + T +L Y +Y ++ + ++ + +R IN V+ Sbjct: 515 -LAMPTTESLAEVYASADQLAIASFYNSKAVEKALNSSLDDARVLINKSVQD 565 >1M2V-B nrPDB Length = 926 Score = 29.6 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 23/172 (13%), Positives = 61/172 (35%), Gaps = 14/172 (8%) Query: 6 ASIGNFT---VDLFNKLNETNRDKNIFFS---PWSISSALAL-TYLAAKGSTAREMAEVL 58 +++ FT + + N + + FS IS + T + A+GST M+ Sbjct: 513 SNLSRFTAGQTHFYPGFSGKNPNDIVKFSTEFAKHISMDFCMETVMRARGSTGLRMSRFY 572 Query: 59 HFTEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYSLRSAN 118 ++ + + R + ++ + + + ++ + + +R Sbjct: 573 GHFFNRSSDLCAFSTMPRDQSYLFEVNVDESIMAD--YCYVQVAVLLSLNNSQRRIRIIT 630 Query: 119 RIYVEKTYALLPTYLQL----SKKYYKAEPQKVNFKTAPEQSRKEINTWVEK 166 + + T +L Y +Y ++ + ++ + +R IN V+ Sbjct: 631 -LAMPTTESLAEVYASADQLAIASFYNSKAVEKALNSSLDDARVLINKSVQD 681 >5ZI5-A nrPDB Length = 921 Score = 28.9 bits (63), Expect = 4.2, Method: Composition-based stats. Identities = 11/67 (16%), Positives = 30/67 (44%), Gaps = 5/67 (7%) Query: 129 LPTYLQLSKKYY----KAEPQKVNF-KTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKA 183 +++ K++ +F ++ S K++ +++ TES I L+ +D++ Sbjct: 420 KEPFIEAVAKFFKDNDGGAVTLEDFIESISNSSGKDLRSFLSWFTESGIPELIVTDELNP 479 Query: 184 TTRLILV 190 T+ + Sbjct: 480 DTKQYFL 486 >1F4Q-A nrPDB Length = 165 Score = 28.5 bits (62), Expect = 5.3, Method: Composition-based stats. Identities = 13/113 (11%), Positives = 34/113 (30%), Gaps = 10/113 (8%) Query: 27 NIFFSPWSISSALALTYLAAKGSTAREMAEVLHFTEAVRAESSSVARPSRGRPKRRRMDP 86 N +SP+S+ + + + + T + + F ++ A + Sbjct: 31 NGTYSPFSLETCRIMIAMLDRDHTGK-----MGFNAFKELWAALNAWKENFMTVDQDGSG 85 Query: 87 EHEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTYLQLSKKY 139 E H ++ + + +L + + Y + Y+ K Sbjct: 86 TVE-----HHELRQAIGLMGYRLSPQTLTTIVKRYSKNGRIFFDDYVACCVKL 133 >4KBM-A nrPDB Length = 409 Score = 28.1 bits (61), Expect = 6.9, Method: Composition-based stats. Identities = 16/87 (18%), Positives = 23/87 (26%) Query: 42 TYLAAKGSTAREMAEVLHFTEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKEL 101 L A G T+ ++ E F+E +R+ + L Sbjct: 206 VLLKALGWTSEQIVERFGFSEIMRSTLEKDNTVGTDEALLDIYRKLRPGEPPTKESAQTL 265 Query: 102 LTAFNKPRNNYSLRSANRIYVEKTYAL 128 L Y L R V K L Sbjct: 266 LENLFFKEKRYDLARVGRYKVNKKLGL 292 >3HJN-A nrPDB Length = 197 Score = 27.7 bits (60), Expect = 8.5, Method: Composition-based stats. Identities = 22/92 (23%), Positives = 35/92 (38%), Gaps = 6/92 (6%) Query: 99 KELLTAFNKPRNNYSLRSANR--IYVEKTYALLPTYLQLSKKYYKAEPQKVNF-KTAPEQ 155 K LL P+ L A+R + E L Y L +Y + F + ++ Sbjct: 48 KILLEEEVTPKAELFLFLASRNLLVTEIKQYLSEGYAVLLDRYTDSSVAYQGFGRNLGKE 107 Query: 156 SRKEINTWVEKQTESKIKNLLSSDDVKATTRL 187 +E+N + T+ I +L DV T L Sbjct: 108 IVEELNDF---ATDGLIPDLTFYIDVDVETAL 136 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.136 0.390 Lambda K H 0.267 0.0418 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,175,353 Number of Sequences: 36641 Number of extensions: 582753 Number of successful extensions: 2279 Number of sequences better than 10.0: 80 Number of HSP's better than 10.0 without gapping: 121 Number of HSP's successfully gapped in prelim test: 26 Number of HSP's that attempted gapping in prelim test: 1592 Number of HSP's gapped (non-prelim): 173 length of query: 410 length of database: 10,336,785 effective HSP length: 99 effective length of query: 311 effective length of database: 6,709,326 effective search space: 2086600386 effective search space used: 2086600386 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 60 (27.7 bits)