BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= O60602 (858 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3J0A-A nrPDB 1709 0.0 5GY2-A nrPDB 216 3e-56 3V44-A nrPDB 182 6e-46 3CIG-A nrPDB 118 1e-26 5ZSN-B nrPDB 117 2e-26 5Y3K-A nrPDB 105 9e-23 4R08-A nrPDB 104 2e-22 3ULU-A nrPDB 87 3e-17 6GFF-I nrPDB 82 1e-15 5Y3M-A nrPDB 80 4e-15 4R6F-A nrPDB 77 4e-14 1FYV-A nrPDB 75 1e-13 1O77-A nrPDB 75 1e-13 3B2D-A nrPDB 74 2e-13 3RG1-A nrPDB 73 5e-13 3T6Q-A nrPDB 72 1e-12 4OM7-A nrPDB 70 3e-12 5LFN-A nrPDB 69 8e-12 2J67-A nrPDB 65 9e-11 5Y31-B nrPDB 64 3e-10 3WPI-A nrPDB 60 6e-09 1XCD-A nrPDB 58 1e-08 2FT3-A nrPDB 56 7e-08 5YQ5-A nrPDB 55 1e-07 2XOT-A nrPDB 54 3e-07 4QDH-A nrPDB 52 8e-07 2Z80-A nrPDB 50 3e-06 3A7C-A nrPDB 48 2e-05 2V9T-B nrPDB 48 2e-05 5XJX-C nrPDB 47 4e-05 5D3I-A nrPDB 47 4e-05 5MX0-A nrPDB 45 1e-04 2Z7X-A nrPDB 44 2e-04 2JS7-A nrPDB 43 6e-04 2Z7X-B nrPDB 42 0.001 6HKW-A nrPDB 42 0.001 4W8H-A nrPDB 40 0.004 6HLU-A nrPDB 39 0.007 4DOM-A nrPDB 39 0.007 6O00-A nrPDB 39 0.008 4PUF-A nrPDB 39 0.008 4FZ5-A nrPDB 38 0.023 4AY9-X nrPDB 38 0.024 5UZB-A nrPDB 37 0.025 1XWD-C nrPDB 37 0.043 1M9S-A nrPDB 36 0.077 1JL5-A nrPDB 35 0.12 5YXM-A nrPDB 35 0.18 5KH1-A nrPDB 32 1.0 2M1W-A nrPDB 32 1.4 3G06-A nrPDB 31 2.2 3G04-C nrPDB 31 2.4 3A79-B nrPDB 30 4.6 4MSX-A nrPDB 30 4.8 1XKT-A nrPDB 30 5.6 5XXB-C nrPDB 30 6.0 4PBW-B nrPDB 29 8.3 5TEB-A nrPDB 29 8.6 4PBV-A nrPDB 29 9.3 >3J0A-A nrPDB Length = 844 Score = 1709 bits (4425), Expect = 0.0, Method: Compositional matrix adjust. Identities = 836/836 (100%), Positives = 836/836 (100%) Query: 23 SCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYT 82 SCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYT Sbjct: 1 SCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYT 60 Query: 83 PLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFR 142 PLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFR Sbjct: 61 PLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFR 120 Query: 143 NLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFS 202 NLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFS Sbjct: 121 NLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFS 180 Query: 203 LAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAH 262 LAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAH Sbjct: 181 LAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAH 240 Query: 263 HIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN 322 HIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN Sbjct: 241 HIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN 300 Query: 323 KINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKF 382 KINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKF Sbjct: 301 KINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKF 360 Query: 383 LEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILY 442 LEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILY Sbjct: 361 LEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILY 420 Query: 443 FLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLS 502 FLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLS Sbjct: 421 FLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLS 480 Query: 503 HLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLA 562 HLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLA Sbjct: 481 HLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLA 540 Query: 563 PNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLF 622 PNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLF Sbjct: 541 PNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLF 600 Query: 623 SLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFKDH 682 SLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFKDH Sbjct: 601 SLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFKDH 660 Query: 683 PQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIA 742 PQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIA Sbjct: 661 PQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIA 720 Query: 743 NIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMK 802 NIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMK Sbjct: 721 NIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMK 780 Query: 803 HQSIRGFVQKQQYLRWPEDFQDVGWFLHKLSQQILKKEKEKKKDNNIPLQTVATIS 858 HQSIRGFVQKQQYLRWPEDFQDVGWFLHKLSQQILKKEKEKKKDNNIPLQTVATIS Sbjct: 781 HQSIRGFVQKQQYLRWPEDFQDVGWFLHKLSQQILKKEKEKKKDNNIPLQTVATIS 836 >5GY2-A nrPDB Length = 455 Score = 216 bits (550), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 157/423 (37%), Positives = 219/423 (51%), Gaps = 13/423 (3%) Query: 20 GIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGS 79 G CS G A L QVP++ + LS N I + +SF L+ LQ L++ Sbjct: 4 GTSECSVIGYNAICINRGLHQVPELPAHVNYVDLSLNSIAELNETSFSRLQDLQFLKVEQ 63 Query: 80 QYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDG 139 Q L I FR L +L IL L ++ L AF GL +L L L C L AVL Sbjct: 64 QTPGLVIRNNTFRGLSSLIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGN 123 Query: 140 YFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLS 199 +F+ L +L L L N I+ + F + +D + N++ +CE +L QGK + Sbjct: 124 FFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLTFNKVKSICEEDLLNFQGKHFT 183 Query: 200 FFSLAANSL--YSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFS 257 L++ +L + + W KC NPF+N + LD+SGNG+ + F +AI+ ++ S Sbjct: 184 LLRLSSITLQDMNEYWLGWEKCGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAGTKIQS 243 Query: 258 LILAH-HIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKV 316 LIL++ + MG+ FG N KDPD TF GL S V+ DLS +F+L VF DL+ Sbjct: 244 LILSNSYNMGSSFGHTNFKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDLEQ 303 Query: 317 LNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQ 376 L LA N+INKI D AF+GL +L LNLS N LG + S F L K+ +DL NHI + Sbjct: 304 LTLAQNEINKIDDNAFWGLTHLLKLNLSQNFLGSIDSRMFENLDKLEVLDLSYNHIRALG 363 Query: 377 DQTFKFLEKLQTLDLRDNALTTIHFIPSIPD-IFLSGNKLVTLPKINLTANLIHLSENRL 435 DQ+F L L+ L L N L S+PD IF ++L +L KI L N S R+ Sbjct: 364 DQSFLGLPNLKELALDTNQLK------SVPDGIF---DRLTSLQKIWLHTNPWDCSCPRI 414 Query: 436 ENL 438 + L Sbjct: 415 DYL 417 Score = 48.5 bits (114), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 86/338 (25%), Positives = 145/338 (42%), Gaps = 60/338 (17%) Query: 290 VRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKIN-KIADEAFYGLDNLQVLNLSYNLL 348 V ++DLS + LN F L+DL+ L + I + F GL +L +L L YN Sbjct: 32 VNYVDLSLNSIAELNETSFSRLQDLQFLKVEQQTPGLVIRNNTFRGLSSLIILKLDYNQF 91 Query: 349 GELYSSNFYGLPKVAYIDLQKNHI--AIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIP 406 +L + F GL + + L + ++ A++ FK L L+ L LRDN + I P+ Sbjct: 92 LQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQ--PA-- 147 Query: 407 DIFLSGNKLVTLPKINLTANLIH-LSENRLENLDILYF-LLRVPHLQILILNQN--RFSS 462 FL+ + L +LT N + + E L N +F LLR+ + + +N+ + Sbjct: 148 SFFLNMRRFHVL---DLTFNKVKSICEEDLLNFQGKHFTLLRLSSITLQDMNEYWLGWEK 204 Query: 463 CSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNY--------- 513 C P +N S+ L L N + + +D G + +Q L L+++Y Sbjct: 205 CG---NPFKNTSITTLDLSGNGFKESMAKRF-FDAIAG-TKIQSLILSNSYNMGSSFGHT 259 Query: 514 ---------------------------LNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDL 546 + +L VFSH T L L+L N + + N Sbjct: 260 NFKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAF 319 Query: 547 PA--NLEILDISRNQLLAPNPDVFVS---LSVLDITHN 579 +L L++S+N L + + +F + L VLD+++N Sbjct: 320 WGLTHLLKLNLSQNFLGSIDSRMFENLDKLEVLDLSYN 357 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 86/351 (24%), Positives = 149/351 (42%), Gaps = 40/351 (11%) Query: 278 DQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFY-GLD 336 + F GLA V L + L+ F+ L L++L L N I KI +F+ + Sbjct: 95 ETGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPASFFLNMR 154 Query: 337 NLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFL--EK--------- 385 VL+L++N + + + + L+ + I + QD +L EK Sbjct: 155 RFHVLDLTFNKVKSICEEDLLNFQGKHFTLLRLSSITL-QDMNEYWLGWEKCGNPFKNTS 213 Query: 386 LQTLDLRDNALTTIHFIPSIPDIF---LSGNKLVTL---PKINLTANLIHLSENRLENLD 439 + TLDL N F S+ F ++G K+ +L N+ ++ H + +N Sbjct: 214 ITTLDLSGNG-----FKESMAKRFFDAIAGTKIQSLILSNSYNMGSSFGHTNFKDPDNF- 267 Query: 440 ILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFE 499 + L ++ L++++ + S LEQL L +N + ++ + F Sbjct: 268 -TFKGLEASGVKTCDLSKSKIFALL-KSVFSHFTDLEQLTLAQNEIN-----KIDDNAFW 320 Query: 500 GLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHND---LPANLEILDIS 556 GL+HL L L+ N+L S+ +F +L L L L+ N + L LP NL+ L + Sbjct: 321 GLTHLLKLNLSQNFLGSIDSRMFENLDKLEVLDLSYNHIRALGDQSFLGLP-NLKELALD 379 Query: 557 RNQLLAPNPDVFVSLSVLD---ITHNKFICECELSTFIN-WLNHTNVTIAG 603 NQL + +F L+ L + N + C C +++ WLN + G Sbjct: 380 TNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLSRWLNKNSQKEQG 430 Score = 36.6 bits (83), Expect = 0.054, Method: Compositional matrix adjust. Identities = 37/105 (35%), Positives = 49/105 (46%), Gaps = 10/105 (9%) Query: 496 DVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRL--TVLSHNDLP--ANLE 551 + F GLS L +L L++N L G F+ L L L+L L VLS N +LE Sbjct: 73 NTFRGLSSLIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLE 132 Query: 552 ILDISRNQLLAPNPDVFV----SLSVLDITHNKF--ICECELSTF 590 +L + N + P F VLD+T NK ICE +L F Sbjct: 133 MLVLRDNNIKKIQPASFFLNMRRFHVLDLTFNKVKSICEEDLLNF 177 >3V44-A nrPDB Length = 407 Score = 182 bits (462), Expect = 6e-46, Method: Compositional matrix adjust. Identities = 127/354 (35%), Positives = 180/354 (50%), Gaps = 3/354 (0%) Query: 20 GIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGS 79 G CS G A L QVP++ + LS N I + +SF L+ LQ L++ Sbjct: 4 GTSECSVIGYNAICINRGLHQVPELPAHVNYVDLSLNSIAELNETSFSRLQDLQFLKVEQ 63 Query: 80 QYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDG 139 Q L I FR L +L IL L ++ L AF GL +L L L C L AVL Sbjct: 64 QTPGLVIRNNTFRGLSSLIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGN 123 Query: 140 YFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLS 199 +F+ L +L L L N I+ + F + +D + N++ +CE +L QGK + Sbjct: 124 FFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLTFNKVKSICEEDLLNFQGKHFT 183 Query: 200 FFSLAANSL--YSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFS 257 L++ +L + + W KC NPF+N + LD+SGNG+ + F +AI+ ++ S Sbjct: 184 LLRLSSITLQDMNEYWLGWEKCGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAGTKIQS 243 Query: 258 LILAH-HIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKV 316 LIL++ + MG+ FG N KDPD TF GL S V+ DLS +F+L VF DL+ Sbjct: 244 LILSNSYNMGSSFGHTNFKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDLEQ 303 Query: 317 LNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKN 370 L LA N+INKI D AF+GL +L+ L L N L + F L + I L N Sbjct: 304 LTLAQNEINKIDDNAFWGLTHLKELALDTNQLKSVPDGIFDRLTSLQKIWLHTN 357 Score = 52.0 bits (123), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 90/363 (24%), Positives = 150/363 (41%), Gaps = 61/363 (16%) Query: 290 VRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKIN-KIADEAFYGLDNLQVLNLSYNLL 348 V ++DLS + LN F L+DL+ L + I + F GL +L +L L YN Sbjct: 32 VNYVDLSLNSIAELNETSFSRLQDLQFLKVEQQTPGLVIRNNTFRGLSSLIILKLDYNQF 91 Query: 349 GELYSSNFYGLPKVAYIDLQKNHI--AIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIP 406 +L + F GL + + L + ++ A++ FK L L+ L LRDN + I P+ Sbjct: 92 LQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQ--PA-- 147 Query: 407 DIFLSGNKLVTLPKINLTANLIH-LSENRLENLDILYF-LLRVPHLQILILNQN--RFSS 462 FL+ + L +LT N + + E L N +F LLR+ + + +N+ + Sbjct: 148 SFFLNMRRFHVL---DLTFNKVKSICEEDLLNFQGKHFTLLRLSSITLQDMNEYWLGWEK 204 Query: 463 CSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNY--------- 513 C P +N S+ L L N + + +D G + +Q L L+++Y Sbjct: 205 CG---NPFKNTSITTLDLSGNGFKESMAKRF-FDAIAG-TKIQSLILSNSYNMGSSFGHT 259 Query: 514 ---------------------------LNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDL 546 + +L VFSH T L L+L N + + N Sbjct: 260 NFKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAF 319 Query: 547 PA--NLEILDISRNQLLAPNPDVFVSLSVLD---ITHNKFICECELSTFIN-WLNHTNVT 600 +L+ L + NQL + +F L+ L + N + C C +++ WLN + Sbjct: 320 WGLTHLKELALDTNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLSRWLNKNSQK 379 Query: 601 IAG 603 G Sbjct: 380 EQG 382 >3CIG-A nrPDB Length = 697 Score = 118 bits (295), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 181/703 (25%), Positives = 303/703 (43%), Gaps = 109/703 (15%) Query: 24 CSFDGRIAFYRFCNLTQVPQVLNTTERLL-LSFNYIRTVTASSFPFLEQLQLLELGSQYT 82 C+ +A LT +P L + +L L+ N +R + ++F QL +L+ G Sbjct: 2 CTVRYNVADCSHLKLTHIPDDLPSNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSI 61 Query: 83 PLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAV--LKDGY 140 ++ E + LP L++L+L +++ + F +L EL L +S+++ +K Sbjct: 62 S-KLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTNLTELDL----MSNSIHKIKSNP 116 Query: 141 FRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSF 200 F+N K L +LDLS N + S L +L+ + + N+I + ELE L +L Sbjct: 117 FKNQKNLIKLDLSHNGLSSTKLGTGVQLE-NLQELLLAKNKILALRSEELEFLGNSSLRK 175 Query: 201 FSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLIL 260 L++N L C + +L+ + +T +S + +L L Sbjct: 176 LDLSSNPLKEFSP----GCFQTIGKLFALLLNNAQ--LNPHLTEKLCWELSNTSIQNLSL 229 Query: 261 AHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLA 320 A++ + A ++TF+GL +++ LDLS+ + + + F L L+ L+L Sbjct: 230 ANNQLLAT---------SESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLE 280 Query: 321 YNKINKIADEAFYGLDNL---------------------------------QVLNLSYNL 347 YN I +++ +FYGL NL + LN+ N Sbjct: 281 YNNIQRLSPRSFYGLSNLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNN 340 Query: 348 LGELYSSNFYGLPKVAYI----------------------------DLQKNHIAIIQDQT 379 + S+ F GL + Y+ +L KNHI+ I + T Sbjct: 341 IPSTKSNTFTGLVSLKYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIANGT 400 Query: 380 FKFLEKLQTLDLRDNALT------TIHFIPSIPDIFLSGNKLVTLP--KINLTANLIHLS 431 F +L +L+ LDL N + + +I +I+LS NK + L L +L L Sbjct: 401 FSWLGQLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKYLQLSTSSFALVPSLQRLM 460 Query: 432 ENR--LENLDILYFLLR-VPHLQILILNQNRFSSCSGDQTPS-ENPSLEQLFLGENMLQL 487 R L+N+DI R + +L IL L+ N ++ + D EN LE L N L Sbjct: 461 LRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDLLEGLEN--LEILDFQHNNLAR 518 Query: 488 AWETELCW---DVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSH- 543 W+ + +GLSHL +L L N L+ +P GVF +L L+ ++L N L L Sbjct: 519 LWKRANPGGPVNFLKGLSHLHILNLESNGLDEIPVGVFKNLFELKSINLGLNNLNKLEPF 578 Query: 544 -NDLPANLEILDISRNQLLAPNPDV----FVSLSVLDITHNKFICECE-LSTFINWLNHT 597 D +L L++ +N + + DV F +L+ LD+ N F C CE +S F+NW+N T Sbjct: 579 IFDDQTSLRSLNLQKNLITSVEKDVFGPPFQNLNSLDMRFNPFDCTCESISWFVNWINQT 638 Query: 598 NVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKF 640 + I+ C P + G L T C + ++L F Sbjct: 639 HTNISELSTHYLCNTPHHYYGFPLKLFDTSSCKDSAPFENLYF 681 >5ZSN-B nrPDB Length = 823 Score = 117 bits (293), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 166/636 (26%), Positives = 274/636 (43%), Gaps = 58/636 (9%) Query: 37 NLTQVPQVLNTT-ERLLLSFNYIRTVTASSFPFLEQLQLLELG----------------S 79 N+T VP VL +T L L N I + F L QLQ+L+L Sbjct: 193 NVTTVPTVLPSTLTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCTPCK 252 Query: 80 QYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDG 139 +PL I AF L L++L L S+ + + P F+ + +L EL L L+ + Sbjct: 253 NNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFLAKEIGDAK 312 Query: 140 YFRNLKALTRLDLSKN---QI--RSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQ 194 + L L +LDLS N Q+ S+ L +F L SLK + + +L PL Sbjct: 313 FLHFLPNLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFQLSPLH 372 Query: 195 G-KTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKS 253 + L L N ++ K + + L + +S +G ++ G+ SNA + Sbjct: 373 NLQNLEVLDLGTN-FIKIANLSMFKQFKRLKVIDLSVNKISPSGDSLVPRGS-SNARTSV 430 Query: 254 QAFSLILAHHIM-------GAGFGFHNIKDPDQNTFAGLARSSVRH---LDLSHGFVFSL 303 +++ + + F N + +F + S ++ LDLS +F + Sbjct: 431 ESYEPQVLEQLYYFRYDKYARSCRFKN----KEASFTSVQESCYKYGQTLDLSKNSIFFI 486 Query: 304 NSRVFETLKDLKVLNLAYNKINKIADEA-FYGLDNLQVLNLSYNLLGELYSSNFYGLPKV 362 S F+ L LK LNL+ N I++ + + F L L+ L+ S N L L+S+ F L K+ Sbjct: 487 KSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELRKL 546 Query: 363 AYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLP-KI 421 +D+ N + L + L + + + I S + L TL + Sbjct: 547 EVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRG 606 Query: 422 NLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLG 481 N L +NR L + LL++ L I + + S D P P+L+ L L Sbjct: 607 NHLDVLWRDGDNRY--LQLFKNLLKLEELDISKNSLSFLPSGVFDGMP---PNLKNLSLA 661 Query: 482 ENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVL 541 +N L+ W+ L +L+ L L+HN L ++P + + +L+ L L +N++ L Sbjct: 662 KNGLK-----SFIWEKLRYLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSL 716 Query: 542 SHNDLPA--NLEILDISRNQLLAPNP-----DVFVSLSVLDITHNKFICECELSTFINWL 594 + L L LD+S N++ +V +L +L + HN+F+C C+ F+ W+ Sbjct: 717 TKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWV 776 Query: 595 NHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCD 630 HT VTI D+ CV P + G S+ SL C+ Sbjct: 777 QHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCE 812 Score = 33.5 bits (75), Expect = 0.36, Method: Compositional matrix adjust. Identities = 77/303 (25%), Positives = 118/303 (38%), Gaps = 52/303 (17%) Query: 300 VFSLNSRVFETLKDLKVLNLAYNKINK--------IADEAFYGLDNLQVLNLSYNLLGEL 351 +FS+ L ++++L L N + I +AF L L+VL+L N Sbjct: 138 IFSIRKEQLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDN----- 192 Query: 352 YSSNFYGLPKV-----AYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIP 406 N +P V + L N IA IQ+ F L +LQ LDL N + P Sbjct: 193 ---NVTTVPTVLPSTLTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRC--YNAPFP 247 Query: 407 DIFLSGNKLVTLPKINLTA----NLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSS 462 N + +P A ++ L N L+++ +F + +LQ L L+QN + Sbjct: 248 CTPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFK-NINNLQELDLSQNFLAK 306 Query: 463 CSGDQTPSEN-PSLEQLFLGENM-LQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPG 520 GD P+L QL L N LQ+ + F L L++L + L Sbjct: 307 EIGDAKFLHFLPNLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSF 366 Query: 521 VFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVS---LSVLDIT 577 S L L+ NLE+LD+ N + N +F L V+D++ Sbjct: 367 QLSPLHNLQ-------------------NLEVLDLGTNFIKIANLSMFKQFKRLKVIDLS 407 Query: 578 HNK 580 NK Sbjct: 408 VNK 410 >5Y3K-A nrPDB Length = 802 Score = 105 bits (262), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 173/658 (26%), Positives = 272/658 (41%), Gaps = 89/658 (13%) Query: 34 RFCNLTQVPQVLNTT-ERLLLSFNYIRTVTASSFPFLEQLQLLELGSQ-------YTPLT 85 ++ NLT VP+ L + E LLLS+N+I T+ L L++L++G P Sbjct: 186 KYNNLTTVPRSLPPSLEYLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCV 245 Query: 86 --------IDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLK 137 + + F +L L L L S +Y L+P F+GL +L L L L D + K Sbjct: 246 ECPHKFPQLHSDTFSHLSRLEGLVLKDSSLYQLNPRWFRGLGNLTVLDLSENFLYDCITK 305 Query: 138 DGYFRNLKALTRLDLSKNQIRS-----LYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEP 192 F+ L L RL+LS N + L L PSFG L SL+ +D + + L+P Sbjct: 306 TKAFQGLAQLRRLNLSFNYHKKVSFAHLTLAPSFGSLLSLQELDMHGIFFRSLSQKTLQP 365 Query: 193 LQG-KTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNA-- 249 L L L N ++ + K R + L +SG V TG Sbjct: 366 LARLPMLQRLYLQMN-FINQAQLGIFKDFPGLRYIDLSDNRISGAVEPVATTGEVDGGKK 424 Query: 250 --------------ISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDL 295 S+ F + +N+ FA L+R ++ L L Sbjct: 425 VWLTSRDLTPGPLDTPSSEDFMPSCKNLSFTLDLSRNNLVTVQPEMFAQLSR--LQCLRL 482 Query: 296 SHGFVF-SLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYN-----LLG 349 SH + ++N F L L+VL+L++NK++ +F L L+ L+LSYN + G Sbjct: 483 SHNSISQAVNGSQFVPLTSLQVLDLSHNKLDLYHGRSFTELPRLEALDLSYNSQPFSMRG 542 Query: 350 ELYSSNFYG-LPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDI 408 ++ +F LP + Y+ L N I Q L LD N+L+ + + Sbjct: 543 VGHNLSFVAQLPTLRYLSLAHNGIHSRVSQQLCS-TSLWALDFSGNSLSQMWAEGDLYLR 601 Query: 409 FLSGNKLVTLPKINLTANLIH-LSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQ 467 F G L +L +++L+ N +H L L NL LLR+ + + N + + Sbjct: 602 FFQG--LRSLIRLDLSQNRLHTLLPCTLGNLPKSLQLLRLRNNYLAFFNWSSLTLL---- 655 Query: 468 TPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTA 527 P+LE L L N L+ L + LQ L ++ N + + PG F+ T Sbjct: 656 -----PNLETLDLAGNQLK-----ALSNGSLPSGTQLQRLDVSRNSIIFVVPGFFALATR 705 Query: 528 LRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECEL 587 LR L+L++N L + P+ L SL VLD++ N C C Sbjct: 706 LRELNLSANALRTVE----PSWFGFLA--------------GSLEVLDVSANPLHCACG- 746 Query: 588 STFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIV 645 + F+++L + G P+ + C P G S+F+ C +E SL + F+V Sbjct: 747 AAFVDFLLQVQAAVPGLPSRVKCGSPGQLQGRSIFAQDLRLCLDE----SLSWDEFLV 800 Score = 38.9 bits (89), Expect = 0.009, Method: Compositional matrix adjust. Identities = 59/225 (26%), Positives = 93/225 (41%), Gaps = 35/225 (15%) Query: 313 DLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHI 372 ++ L+L N+I+ + D F L NLQ LNL +N P + Sbjct: 43 NVTSLSLLSNRIHHLHDSDFAQLSNLQKLNLKWN------------CPPAGLSPMHFPCH 90 Query: 373 AIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSE 432 I+ TF + L+ L+L N +TT+ +PS LV+L I N++ L Sbjct: 91 MTIEPNTFLAVPTLEELNLSYNGITTVPALPS---------SLVSL--ILSRTNILQLDP 139 Query: 433 NRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETE 492 L L L F L ++ N + + P L LG N+ L+ + Sbjct: 140 TSLTGLHALRF---------LYMDGNCYYKNPCGRALEVAPG-ALLGLG-NLTHLSLKYN 188 Query: 493 LCWDVFEGL-SHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSN 536 V L L+ L L++N++ +L P ++LTALR L + N Sbjct: 189 NLTTVPRSLPPSLEYLLLSYNHIVTLAPEDLANLTALRVLDVGGN 233 >4R08-A nrPDB Length = 811 Score = 104 bits (259), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 173/646 (26%), Positives = 268/646 (41%), Gaps = 99/646 (15%) Query: 42 PQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQY----------------TPLT 85 P++ ++ +L LS I+ ++ F L L LL+L + Sbjct: 196 PKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASIN 255 Query: 86 IDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLK 145 ID+ AF+NL LR L+L S+ + ++ F+ + HL L L F L + + L Sbjct: 256 IDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLP 315 Query: 146 ALTRLDLSKNQIRSLY-----LHPSFGKLNSLKSIDFSSNQIFLVCEHELEPL-QGKTLS 199 L LDLS N I+ Y + +F KL SL+++ + E + +PL Q LS Sbjct: 316 RLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLS 375 Query: 200 FFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLI 259 +L N + +D+ K F N LEI+ +S N + + +S A S Sbjct: 376 TINLGINFIK---QIDF-KLFQNFSN--LEIIYLSENRISPLVKD-----TRQSYANSSS 424 Query: 260 LAHHI---MGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKV 316 HI F F DP N F R ++ ++G K Sbjct: 425 FQRHIRKRRSTDFEF----DPHSN-FYHFTRPLIKPQCAAYG----------------KA 463 Query: 317 LNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYS-SNFYGLPKVAYIDLQKNHIAII 375 L+L+ N I I F L ++ LNLS N ++ S + F +P V Y+DL N + Sbjct: 464 LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFD 523 Query: 376 QDQTFKFLEKLQTLDLRDNA-----------LTTIHFIPSIPDIFLSGNKLVTLP-KINL 423 L L+ LDL N+ L I ++ + LS N + TL K NL Sbjct: 524 NASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNL 583 Query: 424 -TANLIHL--SENRLENLDILY---------FLLRVPHLQILILNQNRFSSCSGDQTPSE 471 + +L+ L S NR LDIL+ + +L L L+ NR + + Sbjct: 584 ESKSLVELVFSGNR---LDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNL 640 Query: 472 NPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGL 531 SL +L + +NML+ W + + L++L L N L L + ++LR L Sbjct: 641 PASLTELHINDNMLKF-----FNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTL 695 Query: 532 SLNSNRLTVLSHNDLP--ANLEILDISRNQLLAPNPDVF-----VSLSVLDITHNKFICE 584 L+ NR++ L L ++L+ LD+S N L N LS+L++ N F C Sbjct: 696 LLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECT 755 Query: 585 CELSTFINWLN-HTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGC 629 C++ F W++ H NV I D+ C P G S+ SL C Sbjct: 756 CDIGDFRRWMDEHLNVKIPR-LVDVICASPGDQRGKSIVSLELTTC 800 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 130/538 (24%), Positives = 215/538 (39%), Gaps = 99/538 (18%) Query: 100 LDLGSSKIYFLHPDAFQGLFHLFELRLYF----------CGLSDAVLK--DGYFRNLKAL 147 LDL + I + ++FQGL +L ++ L G+ L DG F NLK L Sbjct: 46 LDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNL 105 Query: 148 TRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANS 207 L L NQ+ + PS G SL + N I+ + + + L L LA N Sbjct: 106 RELLLEDNQLPQI---PS-GLPESLTELSLIQNNIYNITKEGISRLIN--LKNLYLAWNC 159 Query: 208 LYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGA 267 +++V F + L + +++ K L L++ Sbjct: 160 YFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRK-----LFLSN----- 209 Query: 268 GFGFHNIKDPDQNTFAGLARSSVRHLDLS-----------------HGFVFSLNSRVFET 310 IK + F GL ++ LDLS G +++ F+ Sbjct: 210 ----TQIKYISEEDFKGLINLTL--LDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQN 263 Query: 311 LKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYN-LLGELYSSNFYG-LPKVAYIDLQ 368 L L+ LNL+ + KI F + +L+VL+L +N L+GE+ S F LP++ +DL Sbjct: 264 LTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLS 323 Query: 369 KNHIA------IIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKIN 422 N+I I + F L L+ L LR + D F +L L IN Sbjct: 324 FNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELR-----EDDFQPLMQLPNLSTIN 378 Query: 423 LTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGD--QTPSENPSLEQLFL 480 L N I + +D F +L+I+ L++NR S D Q+ + + S ++ Sbjct: 379 LGINFI-------KQIDFKLF-QNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQR--- 427 Query: 481 GENMLQLAWETELCWDVFEGLSHL-------------QVLYLNHNYLNSLPPGVFSHLTA 527 ++ T+ +D H + L L+ N + + P F +L Sbjct: 428 ---HIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPD 484 Query: 528 LRGLSLNSN-RLTVLSHNDLPA--NLEILDISRNQLLAPNPDVFVSLS---VLDITHN 579 + L+L++N VLS + A +++ LD++ N+L N LS VLD+++N Sbjct: 485 IACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYN 542 Score = 37.4 bits (85), Expect = 0.031, Method: Compositional matrix adjust. Identities = 75/322 (23%), Positives = 129/322 (40%), Gaps = 49/322 (15%) Query: 26 FDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLT 85 FD FY F PQ + L LS N I + + F L + L L + Sbjct: 439 FDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQV 498 Query: 86 IDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRL----YFCGLSDAVLKDGYF 141 + F +P+++ LDL ++++ F + A L L L L ++ ++ + Sbjct: 499 LSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFI 558 Query: 142 RNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHE----LEPLQG-K 196 +N L L+LS N I +L + SL + FS N++ ++ + + +G K Sbjct: 559 QNFTNLKVLNLSHNNIYTLTDKYNLES-KSLVELVFSGNRLDILWNDDDNRYISIFKGLK 617 Query: 197 TLSFFSLAANSL------------YSRVSVDWGKCMNPFRNMV-------LEILDVSGNG 237 L+ L+ N L S + M F N LE+LD+ GN Sbjct: 618 NLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNK 677 Query: 238 --WTVDITGNFSNAISKSQAFSLILAHH-IMGAGFGFHNIKDPDQNTFAGLARSSVRHLD 294 + D +F++++ +L+L+H+ I GF + SS++HLD Sbjct: 678 LLFLTDSLSDFTSSLR-----TLLLSHNRISHLPSGFLS------------EVSSLKHLD 720 Query: 295 LSHGFVFSLNSRVFETLKDLKV 316 LS + ++N ET K+ Sbjct: 721 LSSNLLKTINKSALETKTTTKL 742 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 34/115 (29%), Positives = 53/115 (46%), Gaps = 19/115 (16%) Query: 290 VRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINK--------------IADEAFYGL 335 V LDLS F+ + + F+ L++L +NL +N + I D AF L Sbjct: 43 VTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNL 102 Query: 336 DNLQVLNLSYNLLGELYSSNFYGLPK-VAYIDLQKNHIAIIQDQTFKFLEKLQTL 389 NL+ L L N L ++ S GLP+ + + L +N+I I + L L+ L Sbjct: 103 KNLRELLLEDNQLPQIPS----GLPESLTELSLIQNNIYNITKEGISRLINLKNL 153 >3ULU-A nrPDB Length = 694 Score = 87.0 bits (214), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 172/653 (26%), Positives = 283/653 (43%), Gaps = 104/653 (15%) Query: 16 GPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLL-LSFNYIRTVTASSFPFLEQLQL 74 G C+ +A LTQVP L T +L L+ N +R + A++F QL Sbjct: 4 GSASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTS 63 Query: 75 LELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDA 134 L++G T ++ E + LP L++L+L +++ L F +L EL L +S++ Sbjct: 64 LDVGFN-TISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHL----MSNS 118 Query: 135 V--LKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEP 192 + +K+ F K L LDLS N + S L +L+ + S+N+I + EL+ Sbjct: 119 IQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLE-NLQELLLSNNKIQALKSEELD- 176 Query: 193 LQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISK 252 F N L+ L++S N G F +AI + Sbjct: 177 -----------------------------IFANSSLKKLELSSNQIKEFSPGCF-HAIGR 206 Query: 253 SQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLK 312 F L L + +G + LA +S+R+L LS+ + + ++ F LK Sbjct: 207 --LFGLFLNNVQLGPSL--------TEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLK 256 Query: 313 --DLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKN 370 +L +L+L+YN +N + +++F L L+ L YN + L+S + +GL V Y++L+++ Sbjct: 257 WTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRS 316 Query: 371 ---------HIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKI 421 + I D +F++L+ L+ L++ DN IP I +G L+ L + Sbjct: 317 FTKQSISLASLPKIDDFSFQWLKCLEHLNMEDND------IPGIKSNMFTG--LINLKYL 368 Query: 422 NLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLG 481 +L+ + L R + L P L IL L +N+ S D S LE L LG Sbjct: 369 SLSNSFTSL---RTLTNETFVSLAHSP-LHILNLTKNKISKIESDAF-SWLGHLEVLDLG 423 Query: 482 ENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVL 541 N + EL + GL ++ +YL++N L F+ + +L+ L L L + Sbjct: 424 LNEIG----QELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNV 479 Query: 542 SHNDLP----ANLEILDISRNQLLAPNPDVFVS---LSVLDITHNKFICECELSTFINWL 594 + P NL ILD+S N + N D+ L +LD+ HN W Sbjct: 480 DSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARL--------WK 531 Query: 595 NHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDE--EEVLKSLKFSLFIV 645 + A P IY + S + + +L + G DE EV K L F L I+ Sbjct: 532 H------ANPGGPIY--FLKGLSHLHILNLESNGFDEIPVEVFKDL-FELKII 575 Score = 47.4 bits (111), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 102/421 (24%), Positives = 178/421 (42%), Gaps = 63/421 (14%) Query: 43 QVLNTTER-LLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPL-TIDKEAFRNLPNLRIL 100 ++ NT+ R L LS + + T + ++F L+ L L Y L + ++F LP L Sbjct: 228 ELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYF 287 Query: 101 DLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAV-------LKDGYFRNLKALTRLDLS 153 L + I L + GLF++ L L ++ + D F+ LK L L++ Sbjct: 288 FLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNME 347 Query: 154 KNQIRSLYLHPSFGKLN--------SLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAA 205 N I + + G +N S S+ +N+ F+ H L +L Sbjct: 348 DNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHS-------PLHILNLTK 400 Query: 206 NSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIM 265 N + S++ D + LE+LD+ N ++TG + +I Sbjct: 401 NKI-SKIESDAFSWLGH-----LEVLDLGLNEIGQELTGQEWRGL-----------ENIF 443 Query: 266 GAGFGFHNIKDPDQNTFA---GLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN 322 ++ +N+FA L R +R + L + + F+ L++L +L+L+ N Sbjct: 444 EIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKN---VDSSPSPFQPLRNLTILDLSNN 500 Query: 323 KINKIADEAFYGLDNLQVLNLSYNLLGELYSSN--------FYGLPKVAYIDLQKNHIAI 374 I I D+ GL+ L++L+L +N L L+ GL + ++L+ N Sbjct: 501 NIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDE 560 Query: 375 IQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENR 434 I + FK L +L+ +DL N L T +P+ +F N V+L +NL NLI E + Sbjct: 561 IPVEVFKDLFELKIIDLGLNNLNT---LPA--SVF---NNQVSLKSLNLQKNLITSVEKK 612 Query: 435 L 435 + Sbjct: 613 V 613 Score = 38.5 bits (88), Expect = 0.013, Method: Compositional matrix adjust. Identities = 28/85 (32%), Positives = 43/85 (50%), Gaps = 1/85 (1%) Query: 311 LKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKN 370 L L +LNL N ++I E F L L++++L N L L +S F + ++LQKN Sbjct: 545 LSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKN 604 Query: 371 HIAIIQDQTF-KFLEKLQTLDLRDN 394 I ++ + F L LD+R N Sbjct: 605 LITSVEKKVFGPAFRNLTELDMRFN 629 >6GFF-I nrPDB Length = 618 Score = 82.0 bits (201), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 149/590 (25%), Positives = 226/590 (38%), Gaps = 116/590 (19%) Query: 21 IPSCSFDGRIAFYRFCNLTQVPQVLNT-TERLLLSFNYIRTVTASSFPFLEQLQLLELGS 79 +P D +++ + L QVP VL TE L LS N +R++ AS F Sbjct: 5 VPCKMVDKKVS-CQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGF----------- 52 Query: 80 QYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDA-VLKD 138 YT LR LDL +++I FL P AFQ L HL L L L+ A L Sbjct: 53 -YT-------------ALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSA 98 Query: 139 GYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTL 198 G L +T LDLS N + S L G+ SL ++ + N + + H + L Sbjct: 99 GGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDM--PAL 156 Query: 199 SFFSLAANSL---------------YSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDIT 243 L +N L + +S + C++ F L +LD+S N Sbjct: 157 EQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEA--- 213 Query: 244 GNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSL 303 F A F L F PD A L R + +L+LS+ + L Sbjct: 214 --FQTASQPQAEFQLTWLDLRENKLLHF-----PD---LAALPR--LIYLNLSNNLI-RL 260 Query: 304 NSRVFETLKDLKVLNLAYNKINKIA---DEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP 360 + + K + + ++ + A + + L L L+LSYN + + S L Sbjct: 261 PTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLT 320 Query: 361 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHF----IPSIPDIFLSGNKLV 416 + +++L +N + + + L L LDL NAL T+ + S+ + L GN L Sbjct: 321 SLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALR 380 Query: 417 TLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLE 476 LP Y + LQ L L NR S C G P + + Sbjct: 381 DLPP---------------------YTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCV- 418 Query: 477 QLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSN 536 F G++ L+ L L N + L G F H T L L L+SN Sbjct: 419 --------------------AFSGITSLRSLSLVDNEIELLRAGAFLH-TPLTELDLSSN 457 Query: 537 ---RLTVLSHNDLPANLEILDISRNQLLAPNPDV--FVSLSVLDITHNKF 581 + + L A+LE+L + N L+ D+ F+ L L++ N+ Sbjct: 458 PGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRL 507 Score = 53.9 bits (128), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 80/278 (28%), Positives = 113/278 (40%), Gaps = 33/278 (11%) Query: 360 PKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLP 419 P +DL N + I F L+ LDL N ++ + P F + L L Sbjct: 30 PDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQ-----PGAFQALTHLEHL- 83 Query: 420 KINLTANLIHLSENRLENLDILYF--LLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQ 477 L+ NRL L L +P + L L+ N S ++ E PSL Sbjct: 84 ---------SLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHT 134 Query: 478 LFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNR 537 L L EN L T L F + L+ L L+ N L + G F L L L+L+ N Sbjct: 135 LSLAENSL-----TRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNS 189 Query: 538 LTVLSHNDLPANLEILDISRNQL----LAPNPDVFVSLSVLDITHNKFICECELSTF--I 591 LT +S L L +LD+S N + A P L+ LD+ NK + +L+ + Sbjct: 190 LTCISDFSL-QQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRL 248 Query: 592 NWLNHTNVTI---AGPPADIYCVYPDSFSGVSLFSLST 626 +LN +N I GPP D ++ S G S LS Sbjct: 249 IYLNLSNNLIRLPTGPPQDSKGIHAPS-EGWSALPLSA 285 Score = 43.1 bits (100), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 123/509 (24%), Positives = 198/509 (38%), Gaps = 65/509 (12%) Query: 43 QVLNTTERLLLSFNYIRTVTASS---FPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRI 99 Q L E L L+ N + TA S L ++ L+L + + P+L Sbjct: 75 QALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHT 134 Query: 100 LDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRS 159 L L + + L F+ + L +L L+ L D ++DG F L LT L+LS+N + Sbjct: 135 LSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMD--IEDGAFEGLPRLTHLNLSRNSLTC 192 Query: 160 LYLHPSFGKLNSLKSIDFSSNQI--FLVCEHE--------LEPLQGKTLSFFSLAA--NS 207 + S L L+ +D S N I F L+ + K L F LAA Sbjct: 193 I----SDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRL 248 Query: 208 LYSRVSVDWGKC-MNPFRNMVLEILDVSGNGWT-VDITGNFSNAISK--SQAFSLILAHH 263 +Y +S + + P ++ + + GW+ + ++ NA + SQ +L L+++ Sbjct: 249 IYLNLSNNLIRLPTGPPQDS--KGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYN 306 Query: 264 IMG----------AGFGFHNIKDPDQNTFAGLARSSVRHL---DLSHGFVFSLNSRVFET 310 + F N+ TF S+ L DLSH + +L Sbjct: 307 EIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-RA 365 Query: 311 LKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL---------GELYSSNFYGLPK 361 L L+ L L N + + F L +LQ LNL N + G F G+ Sbjct: 366 LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITS 425 Query: 362 VAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIH------FIPSIPDIFLSGNKL 415 + + L N I +++ F L LDL N + S+ + L GN L Sbjct: 426 LRSLSLVDNEIELLRAGAF-LHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGL 484 Query: 416 VTLPKINLTA----NLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSE 471 + L +++L ++L+ENRL +L + L++L L N FS G Sbjct: 485 MVL-QVDLPCFICLKRLNLAENRLSHLPAWT---QAVSLEVLDLRNNSFSLLPGSAMGGL 540 Query: 472 NPSLEQLFLGENMLQLAWETELCWDVFEG 500 SL +L+L N L L + +G Sbjct: 541 ETSLRRLYLQGNPLSCCGNGWLAAQLHQG 569 >5Y3M-A nrPDB Length = 801 Score = 80.1 bits (196), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 162/663 (24%), Positives = 262/663 (39%), Gaps = 118/663 (17%) Query: 34 RFCNLTQVPQVLNTT-ERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFR 92 ++ NLT+VP+ L + + LLLS+N+I T+ L L++L++G + R Sbjct: 186 KYNNLTEVPRRLPPSLDTLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCR 245 Query: 93 NLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDL 152 P LHPD F L L L L L L+ +FR L L LDL Sbjct: 246 ECPK---------NFPKLHPDTFSHLSRLEGLVLKDSSLYK--LEKDWFRGLGRLQVLDL 294 Query: 153 SKN----------------QIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGK 196 S+N Q+R L L ++ K S + +S+ LV LE L Sbjct: 295 SENFLYDYITKTTIFNDLTQLRRLNLSFNYHKKVSFAHLHLASSFGSLV---SLEKLDMH 351 Query: 197 TLSFFSLAANSLYSRVSVDWGKCMNPFRNMV----LEILDVSGNGWTVDITGN-FSNAIS 251 + F SL +L S + + ++ N + L I + VD++ N S A + Sbjct: 352 GIFFRSLTNITLQSLTRLPKLQSLHLQLNFINQAQLSIFGAFPSLLFVDLSDNRISGAAT 411 Query: 252 KSQAFSLI------------LAHHIMGA----------------GFGFHNIKDPDQNTFA 283 + A + LA + A +N+ Q F Sbjct: 412 PAAALGEVDSRVEVWRLPRGLAPGPLDAVSSKDFMPSCNLNFTLDLSRNNLVTIQQEMFT 471 Query: 284 GLARSSVRHLDLSHGFVF-SLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLN 342 L+R ++ L LSH + ++N F L L+VL+L++NK++ +F L L+ L+ Sbjct: 472 RLSR--LQCLRLSHNSISQAVNGSQFVPLTSLRVLDLSHNKLDLYHGRSFTELPQLEALD 529 Query: 343 LSYN-----LLGELYSSNFYG-LPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNAL 396 LSYN + G ++ +F LP + Y+ L N I Q L+ LD N+L Sbjct: 530 LSYNSQPFSMQGVGHNLSFVAQLPSLRYLSLAHNGIHSRVSQKLSS-ASLRALDFSGNSL 588 Query: 397 TTIHFIPSIPDIFLSGNKLVTLPKINLTANLIH-LSENRLENLDILYFLLRVPHLQILIL 455 + + + F G L L +++L+ N +H L L+NL LR+ + Sbjct: 589 SQMWAEGDLYLCFFKG--LRNLVQLDLSENHLHTLLPRHLDNLPKSLRQLRLRDNNLAFF 646 Query: 456 NQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLN 515 N + + P LE L L N L+ L + LQ L ++ N + Sbjct: 647 NWSSLTVL---------PRLEALDLAGNQLKALSNGSLPPGI-----RLQKLDVSSNSIG 692 Query: 516 SLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLS--- 572 + PG F T L L+L++N L + +P F SL+ Sbjct: 693 FVIPGFFVRATRLIELNLSANALKTV----------------------DPSWFGSLAGTL 730 Query: 573 -VLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDE 631 +LD++ N C C + F+++L + G + C P G S+F+ C + Sbjct: 731 KILDVSANPLHCACG-AAFVDFLLERQEAVPGLSRRVTCGSPGQLQGRSIFTQDLRLCLD 789 Query: 632 EEV 634 E + Sbjct: 790 ETL 792 Score = 33.5 bits (75), Expect = 0.44, Method: Compositional matrix adjust. Identities = 24/87 (27%), Positives = 39/87 (44%), Gaps = 12/87 (13%) Query: 313 DLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHI 372 ++ L+L N+I+ + D F L NL+VLNL +N P + Sbjct: 43 NVTSLSLISNRIHHLHDSDFVHLSNLRVLNLKWN------------CPPAGLSPMHFPCR 90 Query: 373 AIIQDQTFKFLEKLQTLDLRDNALTTI 399 I+ TF + L+ L+L N +TT+ Sbjct: 91 MTIEPNTFLAVPTLEELNLSYNGITTV 117 >4R6F-A nrPDB Length = 331 Score = 76.6 bits (187), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 85/277 (30%), Positives = 126/277 (45%), Gaps = 38/277 (13%) Query: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348 +VR+L L + + + L +L LNL+ N++ + F L NL LNLS N L Sbjct: 64 NVRYLALGGNKLHDI--SALKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQL 121 Query: 349 GELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI--HFIPSIP 406 L F L + ++L N+IA I DQ + L L TL+L N L + H P P Sbjct: 122 TSLPQGVFERLASLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGGP 181 Query: 407 DIFLSGNKLVTLPKINLTAN-----------------LIHLSENRLENLDILYFLLRVPH 449 FL G L L +NL++N ++LS N + N++ L + + Sbjct: 182 IYFLKG--LTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNNIANIND-QMLEGLTN 238 Query: 450 LQILILNQNRFSSCSGDQTPSENP--------SLEQLFLGENMLQLAWETELCWDVFEGL 501 L L L+ N + P P +L L L N E+ +VF+ L Sbjct: 239 LTTLNLSHNNLARLWKHANPG-GPIYFLKGLTNLTTLNLSSNGFD-----EIPREVFKDL 292 Query: 502 SHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRL 538 + L L L++N L SLP GVF LT L+ L+L++N+L Sbjct: 293 TSLTTLNLSNNQLTSLPQGVFERLTNLKTLNLSNNQL 329 Score = 70.1 bits (170), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 90/316 (28%), Positives = 145/316 (45%), Gaps = 51/316 (16%) Query: 89 EAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALT 148 + + LPN+R L LG +K++ + A + L +L L L L L G F L LT Sbjct: 57 QGIQYLPNVRYLALGGNKLHDI--SALKELTNLGWLNLSNNQLE--TLPQGVFEKLTNLT 112 Query: 149 RLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSL 208 L+LS NQ+ SL F +L SL +++ S+N I + + LE L L+ +L+ N+L Sbjct: 113 TLNLSNNQLTSLP-QGVFERLASLTTLNLSNNNIANINDQMLEGLTN--LTTLNLSHNNL 169 Query: 209 YSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAG 268 +R+ W K NP + L N T++++ N Sbjct: 170 -ARL---W-KHANPGG--PIYFLKGLTNLTTLNLSSN----------------------- 199 Query: 269 FGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIA 328 GF I + F L +S+ L+LS+ + ++N ++ E L +L LNL++N + ++ Sbjct: 200 -GFDEIP---REVFKDL--TSLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLW 253 Query: 329 DEA--------FYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTF 380 A GL NL LNLS N E+ F L + ++L N + + F Sbjct: 254 KHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNQLTSLPQGVF 313 Query: 381 KFLEKLQTLDLRDNAL 396 + L L+TL+L +N L Sbjct: 314 ERLTNLKTLNLSNNQL 329 Score = 39.7 bits (91), Expect = 0.006, Method: Compositional matrix adjust. Identities = 36/127 (28%), Positives = 63/127 (49%), Gaps = 31/127 (24%) Query: 86 IDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRL------------------Y 127 I +E F++L +L L+L ++ I ++ +GL +L L L Y Sbjct: 204 IPREVFKDLTSLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIY 263 Query: 128 FC-GLSDAVL----KDGY-------FRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSI 175 F GL++ +G+ F++L +LT L+LS NQ+ SL F +L +LK++ Sbjct: 264 FLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNQLTSLP-QGVFERLTNLKTL 322 Query: 176 DFSSNQI 182 + S+NQ+ Sbjct: 323 NLSNNQL 329 Score = 36.6 bits (83), Expect = 0.045, Method: Compositional matrix adjust. Identities = 73/259 (28%), Positives = 115/259 (44%), Gaps = 44/259 (16%) Query: 399 IHFIPSIPDIFLSGNKLVTLPKINLTANL--IHLSENRLENLDILYFLLRVPHLQILILN 456 I ++P++ + L GNKL + + NL ++LS N+LE L F ++ +L L L+ Sbjct: 59 IQYLPNVRYLALGGNKLHDISALKELTNLGWLNLSNNQLETLPQGVF-EKLTNLTTLNLS 117 Query: 457 QNRFSSCSGDQTPSEN-PSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLN 515 N+ +S Q E SL L L N + + + EGL++L L L+HN L Sbjct: 118 NNQLTSLP--QGVFERLASLTTLNLSNNNI-----ANINDQMLEGLTNLTTLNLSHNNLA 170 Query: 516 SL-----PPG---VFSHLTALRGLSLNSNRLTVLSH---NDLPANLEILDISRNQLLAPN 564 L P G LT L L+L+SN + DL + L L++S N + N Sbjct: 171 RLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTS-LTTLNLSNNNIANIN 229 Query: 565 PDV---FVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSL 621 + +L+ L+++HN L W + A P IY + + ++ Sbjct: 230 DQMLEGLTNLTTLNLSHNNL---ARL-----WKH------ANPGGPIY--FLKGLTNLTT 273 Query: 622 FSLSTEGCDE--EEVLKSL 638 +LS+ G DE EV K L Sbjct: 274 LNLSSNGFDEIPREVFKDL 292 >1FYV-A nrPDB Length = 161 Score = 75.1 bits (183), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 41/155 (26%), Positives = 81/155 (52%), Gaps = 6/155 (3%) Query: 692 KYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNS 751 ++ A++ +S D WV+N LL +L+ + +C ER+FVPG++ + NI I S Sbjct: 12 QFHAFISYSGHDSFWVKNELLPNLEKE-----GMQICLHERNFVPGKSIVENIITCIEKS 66 Query: 752 RKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQL-MKHQSIRGFV 810 K + ++S +F++ WC +A + +++LI++++ + QY + + ++ + Sbjct: 67 YKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPSSYHKLKSLM 126 Query: 811 QKQQYLRWPEDFQDVGWFLHKLSQQILKKEKEKKK 845 ++ YL WP++ G F L I K E+ K Sbjct: 127 ARRTYLEWPKEKSKRGLFWANLRAAINIKLTEQAK 161 >1O77-A nrPDB Length = 146 Score = 74.7 bits (182), Expect = 1e-13, Method: Composition-based stats. Identities = 38/130 (29%), Positives = 71/130 (54%), Gaps = 4/130 (3%) Query: 693 YDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSR 752 YDA++ +S +D WV+N +++ L+ + F LC +RDF+PG+ I NI D+I S Sbjct: 3 YDAFVSYSERDAYWVENLMVQELE---NFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSH 59 Query: 753 KIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQL-MKHQSIRGFVQ 811 K V ++S +F++ W ++ R + N A I++++ + + + + +R + Sbjct: 60 KTVFVLSENFVKSEWSKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMN 119 Query: 812 KQQYLRWPED 821 + YL WP D Sbjct: 120 TKTYLEWPMD 129 >3B2D-A nrPDB Length = 603 Score = 74.3 bits (181), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 145/565 (25%), Positives = 229/565 (40%), Gaps = 91/565 (16%) Query: 38 LTQVPQVL-NTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPN 96 L+++P L NTTE L SFN++ T+ +F L L L+L ++ I ++ F++ Sbjct: 21 LSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDL-TRCQINWIHEDTFQSHHQ 79 Query: 97 LRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQ 156 L L L + + F+ + G L L L G+S+ L+ NL+ L L L N Sbjct: 80 LSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISN--LEFIPVHNLENLESLYLGSNH 137 Query: 157 IRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDW 216 I S+ F N LK +DF +N I + ++ L+ + N++ Sbjct: 138 ISSIKFPKDFPARN-LKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVK------- 189 Query: 217 GKCMNPFRNMVLEILDVSGNGWTVDITGNFS---NAISKSQAFSLILAHHIMGAGFGFHN 273 G + F + + + L+ G T N S N + S SL L F + Sbjct: 190 GIELGAFDSTIFQSLNFGG-------TPNLSVIFNGLQNSTTQSLWLG--------TFED 234 Query: 274 IKDPDQNT--FAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEA 331 I D D ++ GL SV L+L ++S F+ L+ L+L + + Sbjct: 235 IDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLP-SG 293 Query: 332 FYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYI----DLQKNHIAIIQDQTFKFLEKLQ 387 GL+ L+ L LS N +L + P + ++ +++K H+ + + L LQ Sbjct: 294 MKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGV---GCLEKLGNLQ 350 Query: 388 TLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRV 447 TLDL N DI S + L NL HL L + Sbjct: 351 TLDLSHN------------DIEASDCCSLQL------KNLSHLQT------------LNL 380 Query: 448 PHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVL 507 H + L L F C P LE L L L + F+ L LQVL Sbjct: 381 SHNEPLGLQSQAFKEC---------PQLELLDLAFTRLHINAP----QSPFQNLHFLQVL 427 Query: 508 YLNHNYLNSLPPGVFSHLTALRGLSLNSNRL---TVLSHNDLP--ANLEILDISRNQLLA 562 L + +L++ + + L LR L+L N T+ N L +LE+L +S LL+ Sbjct: 428 NLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLS 487 Query: 563 PNPDVFVSL---SVLDITHNKFICE 584 + F SL S +D++HN C+ Sbjct: 488 IDQQAFHSLGKMSHVDLSHNSLTCD 512 >3RG1-A nrPDB Length = 612 Score = 73.2 bits (178), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 158/635 (24%), Positives = 251/635 (39%), Gaps = 111/635 (17%) Query: 38 LTQVPQVL-NTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPN 96 L ++P L NTTE L SFN++ T+ ++F L L L+L ++ + ++ F++ Sbjct: 23 LREIPDTLPNTTEVLEFSFNFLPTIQNTTFSRLINLIFLDL-TRCQINWVHEDTFQSHHQ 81 Query: 97 LRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQ 156 L + L + + F+ + G L L L G+S+ L+ NL+ L L L N Sbjct: 82 LNTIVLTGNPLIFMAETSLTGPKFLKHLFLTQTGISN--LEFIPVHNLENLESLHLGSNH 139 Query: 157 IRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKT---LSF-----FSLAANSL 208 I S+ L +F N LK +DF +N I + + L+ T L+F + + Sbjct: 140 ISSINLPENFPTQN-LKVLDFQNNAIHYISRKDTNSLEQATNLSLNFNGNDIKGIEPGAF 198 Query: 209 YSRV--SVDWGKCMNPF------RNMVLEILDVSGNGWTVDITGNFSNAISK---SQAFS 257 S++ S+ +G +N F +N L+ L W G F + + S F Sbjct: 199 ISKIFQSLKFGGSLNLFIIFKGLQNSTLQSL------W----LGTFEDTDDQYLTSATFE 248 Query: 258 LILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVL 317 + + H D +TF R V+ LDL+ + L S + E + LK L Sbjct: 249 GLCDMSVESINLQKHRFSDLSSSTFRCFTR--VQELDLTAAHLNGLPSGI-EGMNSLKKL 305 Query: 318 NLAYNKINK-------------------------IADEAFYGLDNLQVLNLSYNLLGELY 352 L N ++ + L+NLQ L+LS++ + Sbjct: 306 VLNANSFDQLCQINAASFPSLRDLYIKGNMRKLDLGTRCLEKLENLQKLDLSHSDIEASD 365 Query: 353 SSNFY--GLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHF-IPSIPDIF 409 N L + Y++L N ++DQ FK +L+ LD+ A T +H P P Sbjct: 366 CCNLQLKNLRHLQYLNLSYNEPLGLEDQAFKECPQLELLDV---AFTHLHVKAPHSP--- 419 Query: 410 LSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTP 469 L L +NL+ L+ S L L + L+ L L N F S +T Sbjct: 420 --FQNLHLLRVLNLSHCLLDTSNQHL--------LAGLQDLRHLNLQGNSFQDGSISKTN 469 Query: 470 --SENPSLEQLFLGE-NMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLT 526 SLE L L N+L + + F GL ++ L L+HN L SHL Sbjct: 470 LLQMVGSLEILILSSCNLLSIDQQ------AFHGLRNVNHLDLSHNSLTGDSMDALSHLK 523 Query: 527 ALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECE 586 L L++ SN + ++ + LPA S+++++HN C C Sbjct: 524 GLY-LNMASNNIRIIPPHLLPA-------------------LSQQSIINLSHNPLDCTCS 563 Query: 587 LSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSL 621 FI W N+ + C P S GV L Sbjct: 564 NIHFITWYKE-NLHKLEDSEETTCANPPSLRGVKL 597 >3T6Q-A nrPDB Length = 606 Score = 72.0 bits (175), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 143/606 (23%), Positives = 249/606 (41%), Gaps = 53/606 (8%) Query: 38 LTQVPQVL-NTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPN 96 L ++P L N+TE L SFN + T+ ++F L L L+L ++ I ++ F++ Sbjct: 24 LNEIPGTLPNSTECLEFSFNVLPTIQNTTFSRLINLTFLDL-TRCQIYWIHEDTFQSQHR 82 Query: 97 LRILDLGSSKIYFLHPDAFQG---LFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLS 153 L L L ++ + F+ A G L HLF ++ + L N K L L L Sbjct: 83 LDTLVLTANPLIFMAETALSGPKALKHLFFIQTGISSIDFIPL-----HNQKTLESLYLG 137 Query: 154 KNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVS 213 N I S+ L F LK +DF +N I + + ++ LQ T +L N + Sbjct: 138 SNHISSIKLPKGFPT-EKLKVLDFQNNAIHYLSKEDMSSLQQATNLSLNLNGNDI---AG 193 Query: 214 VDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHN 273 ++ G F + V + L+ G + I N+ +S F + Sbjct: 194 IEPGA----FDSAVFQSLNFGGTQNLLVIFKGLKNSTIQSLWLG------------TFED 237 Query: 274 IKDPDQN--TFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEA 331 + D D + F GL SV ++L + F+++S F L+ L+L ++++ Sbjct: 238 MDDEDISPAVFEGLCEMSVESINLQKHYFFNISSNTFHCFSGLQELDLTATHLSELPS-G 296 Query: 332 FYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAI-IQDQTFKFLEKLQTLD 390 GL L+ L LS N L + P + ++ ++ N + + + LE L+ LD Sbjct: 297 LVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTKRLELGTGCLENLENLRELD 356 Query: 391 LRDNALTT-------IHFIPSIPDIFLSGNKLVTLP----KINLTANLIHLSENRLENLD 439 L + + T + + + + LS N+ ++L K L+ L+ RL+ D Sbjct: 357 LSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKD 416 Query: 440 ILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFE 499 + L++L L+ + S +Q P+L+ L L N + + + Sbjct: 417 AQSPFQNLHLLKVLNLSHSLL-DISSEQLFDGLPALQHLNLQGNHFPKGNIQK--TNSLQ 473 Query: 500 GLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEI-LDISRN 558 L L++L L+ L+S+ F+ L + + L+ NRLT S L I L+++ N Sbjct: 474 TLGRLEILVLSFCDLSSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNLASN 533 Query: 559 QLLAPNPDVFVSLS---VLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDS 615 + P + LS +++ N C C F+ W N+ D C P Sbjct: 534 HISIILPSLLPILSQQRTINLRQNPLDCTCSNIYFLEWYKE-NMQKLEDTEDTLCENPPL 592 Query: 616 FSGVSL 621 GV L Sbjct: 593 LRGVRL 598 Score = 32.7 bits (73), Expect = 0.68, Method: Compositional matrix adjust. Identities = 26/83 (31%), Positives = 41/83 (49%), Gaps = 1/83 (1%) Query: 315 KVLNLAYNKINKIADEAFYGLDN-LQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIA 373 K +N YN N +E L N + L S+N+L + ++ F L + ++DL + I Sbjct: 11 KEVNKTYNCENLGLNEIPGTLPNSTECLEFSFNVLPTIQNTTFSRLINLTFLDLTRCQIY 70 Query: 374 IIQDQTFKFLEKLQTLDLRDNAL 396 I + TF+ +L TL L N L Sbjct: 71 WIHEDTFQSQHRLDTLVLTANPL 93 >4OM7-A nrPDB Length = 179 Score = 70.5 bits (171), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 34/138 (24%), Positives = 76/138 (55%), Gaps = 6/138 (4%) Query: 692 KYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNS 751 ++ A++ +S D WV++ L+ +L+ + +C ER+FVPG++ + NI + I S Sbjct: 2 QFHAFISYSEHDSAWVKSELVPYLEKE-----DIQICLHERNFVPGKSIVENIINCIEKS 56 Query: 752 RKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLM-KHQSIRGFV 810 K + ++S +F++ WC +A + ++ LI++++ + Q + K+ ++ + Sbjct: 57 YKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALM 116 Query: 811 QKQQYLRWPEDFQDVGWF 828 ++ YL+WP++ G F Sbjct: 117 TQRTYLQWPKEKSKRGLF 134 >5LFN-A nrPDB Length = 337 Score = 68.9 bits (167), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 88/338 (26%), Positives = 146/338 (43%), Gaps = 44/338 (13%) Query: 292 HLDLSHGFVFSLN-SRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGE 350 H DL H + ++ + + K+LNL N +A +F + NL L+L + + E Sbjct: 8 HSDLQHVICDKVGLQKIPKVSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIRE 67 Query: 351 LYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI--HFIPSIPDI 408 + + F GL ++ Y+ L N I +++ F L +L L L N +T + + + ++ Sbjct: 68 VAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNL 127 Query: 409 F---LSGNKLVTLPKINLTA----NLIHLSENRLENLDILYFLLRVPHLQILILNQNRFS 461 F L+ NK+ L ++LSEN L +L L V +L +++N+ S Sbjct: 128 FILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQP-GALDDVENLAKFHVDRNQLS 186 Query: 462 SCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLS-HLQVLYLNHNYLNSLPPG 520 S S+ +E+L L N L+ + + F+ +L+ L+L++ L G Sbjct: 187 SYPSAAL-SKLRVVEELKLSHNPLK-----SIPDNAFQSFGRYLETLWLDNTNLEKFSDG 240 Query: 521 VFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNK 580 F +T L+ + L +NRL N LP+N F SL L +T+N Sbjct: 241 AFLGVTTLKHVHLENNRL-----NQLPSNFP----------------FDSLETLALTNNP 279 Query: 581 FICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSG 618 + C C+L WL A P D C P F G Sbjct: 280 WKCTCQLRGLRRWLE----AKASRP-DATCASPAKFKG 312 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 58/221 (26%), Positives = 101/221 (45%), Gaps = 18/221 (8%) Query: 274 IKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFY 333 I++ F GL + + +L LSH + L + F+ L +L L L +NK+ ++ Sbjct: 65 IREVAAGAFRGLKQ--LIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLS 122 Query: 334 GLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRD 393 L NL +L L+ N + EL + F G + ++ L +N ++ +Q +E L + Sbjct: 123 PLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQPGALDDVENLAKFHVDR 182 Query: 394 NALTT-----IHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYF----L 444 N L++ + + + ++ LS N L ++P + +L L+N ++ F Sbjct: 183 NQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTNLEKFSDGAF 242 Query: 445 LRVPHLQILILNQNRFSSCSGDQTPSENP--SLEQLFLGEN 483 L V L+ + L NR +Q PS P SLE L L N Sbjct: 243 LGVTTLKHVHLENNRL-----NQLPSNFPFDSLETLALTNN 278 Score = 36.6 bits (83), Expect = 0.050, Method: Compositional matrix adjust. Identities = 31/91 (34%), Positives = 45/91 (49%), Gaps = 3/91 (3%) Query: 70 EQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFC 129 E+ +LL L P+ + +FR +PNL L L +I + AF+GL L + LY Sbjct: 29 EKTKLLNLQRNNFPV-LAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQL--IYLYLS 85 Query: 130 GLSDAVLKDGYFRNLKALTRLDLSKNQIRSL 160 VL+ G F +L LT L L N++ L Sbjct: 86 HNDIRVLRAGAFDDLTELTYLYLDHNKVTEL 116 Score = 33.5 bits (75), Expect = 0.43, Method: Compositional matrix adjust. Identities = 50/192 (26%), Positives = 76/192 (39%), Gaps = 50/192 (26%) Query: 38 LTQVPQVLNTTERLLLSFN------------------------YIRTVTASSFPFLEQL- 72 L ++P+V T+ L L N IR V A +F L+QL Sbjct: 21 LQKIPKVSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIREVAAGAFRGLKQLI 80 Query: 73 ---------QLLELGS-----QYTPLTIDKEAFRNLP--------NLRILDLGSSKIYFL 110 ++L G+ + T L +D LP NL IL L ++KI L Sbjct: 81 YLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNLFILQLNNNKIREL 140 Query: 111 HPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLN 170 AFQG L L L LS L+ G +++ L + + +NQ+ S Y + KL Sbjct: 141 RAGAFQGAKDLRWLYLSENALSS--LQPGALDDVENLAKFHVDRNQLSS-YPSAALSKLR 197 Query: 171 SLKSIDFSSNQI 182 ++ + S N + Sbjct: 198 VVEELKLSHNPL 209 >2J67-A nrPDB Length = 178 Score = 65.5 bits (158), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 36/146 (24%), Positives = 75/146 (51%), Gaps = 4/146 (2%) Query: 692 KYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNS 751 ++ A++ +S D WV+N L+ +L+ + +C E F PG++ NI I S Sbjct: 35 RFHAFISYSEHDSLWVKNELIPNLEKE---DGSILICLYESYFDPGKSISENIVSFIEKS 91 Query: 752 RKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQL-MKHQSIRGFV 810 K + ++S +F+++ WC F +A + + +I++++ + Y + ++ ++ + Sbjct: 92 YKSIFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALL 151 Query: 811 QKQQYLRWPEDFQDVGWFLHKLSQQI 836 +K+ YL WP+D + G F L I Sbjct: 152 EKKAYLEWPKDRRKCGLFWANLRAAI 177 >5Y31-B nrPDB Length = 544 Score = 63.9 bits (154), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 48/158 (30%), Positives = 72/158 (45%), Gaps = 28/158 (17%) Query: 473 PSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLS 532 PSL+ L N + + D F GL HL+ L++ +N + S+ F L +L LS Sbjct: 71 PSLQLLLFTSNSFDVISD-----DAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLS 125 Query: 533 LNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFIN 592 L +N L L D+ L+ SL+ +D+ N F C+C+L + Sbjct: 126 LANNNLQTLP-KDIFKGLD------------------SLTNVDLRGNSFNCDCKLKWLVE 166 Query: 593 WLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCD 630 WL HTN T+ DIYC P + + SLS++ D Sbjct: 167 WLGHTNATV----EDIYCEGPPEYKKRKINSLSSKDFD 200 Score = 43.9 bits (102), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 32/120 (26%), Positives = 54/120 (45%), Gaps = 11/120 (9%) Query: 314 LKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIA 373 L++L N + I+D+AF GL +L+ L + N + + F GL + ++ L N++ Sbjct: 73 LQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQ 132 Query: 374 IIQDQTFKFLEKLQTLDLRDNALTTI-----------HFIPSIPDIFLSGNKLVTLPKIN 422 + FK L+ L +DLR N+ H ++ DI+ G KIN Sbjct: 133 TLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKIN 192 Score = 38.1 bits (87), Expect = 0.017, Method: Compositional matrix adjust. Identities = 25/87 (28%), Positives = 45/87 (51%) Query: 313 DLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHI 372 D+ L+ + +I++ +F +LQ+L + N + F GLP + Y+ ++ N+I Sbjct: 48 DVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNI 107 Query: 373 AIIQDQTFKFLEKLQTLDLRDNALTTI 399 I TF+ L+ L L L +N L T+ Sbjct: 108 KSISRHTFRGLKSLIHLSLANNNLQTL 134 Score = 35.8 bits (81), Expect = 0.089, Method: Compositional matrix adjust. Identities = 33/108 (30%), Positives = 52/108 (48%), Gaps = 7/108 (6%) Query: 52 LLSFNYIRT----VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKI 107 ++S +++R+ ++ SF F LQLL S + I +AF LP+L L + ++ I Sbjct: 49 VISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDV-ISDDAFIGLPHLEYLFIENNNI 107 Query: 108 YFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKN 155 + F+GL L L L L L F+ L +LT +DL N Sbjct: 108 KSISRHTFRGLKSLIHLSLANNNLQ--TLPKDIFKGLDSLTNVDLRGN 153 >3WPI-A nrPDB Length = 803 Score = 59.7 bits (143), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 151/649 (23%), Positives = 262/649 (40%), Gaps = 92/649 (14%) Query: 34 RFCNLTQVPQVLNTT-ERLLLSFNYIRTVTASSFPFLEQLQLLELGSQ-----YTP---- 83 ++ NLT+VP+ L + E LL+S+N I + L L++L++G + P Sbjct: 186 KYNNLTKVPRQLPPSLEYLLVSYNLIVKLGPEDLAQLTSLRVLDVGGNCRRCDHAPNPCI 245 Query: 84 ------LTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLK 137 L + E F +L +L L L S ++ L+ FQGL L L L L +++ Sbjct: 246 ECGQKSLHLHPETFHHLSHLEGLVLKDSSLHTLNSSWFQGLVQLSVLDLSENFLYESITH 305 Query: 138 DGYFRNLKALTRLDLSKNQIRS-----LYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEP 192 F+NL L +L+LS N + L+L SF L SL+ ++ + L+ ++ L Sbjct: 306 TNAFQNLTRLRKLNLSFNYRKKVSFARLHLASSFKNLVSLQELNMNGIFFRLLNKYTLRW 365 Query: 193 LQG-KTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFS---- 247 L L L N ++ + R + L +SG + T + Sbjct: 366 LADLPKLHTLHLQMN-FINQAQLSIFGTFRALRFVDLSDNRISGPSTLSEATPEEADDAE 424 Query: 248 -----NAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLAR------SSVRHLDLS 296 +A S + + M F D +N + S ++ L LS Sbjct: 425 QEELLSADPHPAPLSTPASKNFMDRCKNFKFTMDLSRNNLVTIKPEMFVQLSRLQCLSLS 484 Query: 297 HGFVF-SLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSN 355 H + ++N F L +L+VL+L++NK++ ++F L LQ L+LSYN S Sbjct: 485 HNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYN-------SQ 537 Query: 356 FYGLPKVAYIDLQKNHIAIIQDQTFKFLE------------KLQTLDLRDNALTTIHFIP 403 + + + + H++++Q + + ++ LD N + + Sbjct: 538 PFSMKGIGHQFSFVTHLSMLQSLSLAHNDIHTRVSSHLNSNSVRFLDFSGNGMGRMWDEG 597 Query: 404 SIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSC 463 + F G L L K++L+ N +H+ R +NLD +P L+ ++ + S Sbjct: 598 GLYLHFFQG--LSGLLKLDLSQNNLHIL--RPQNLD------NLPKSLKLLSLRDNYLSF 647 Query: 464 SGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFS 523 + S P+LE L L N L+ L + LQ L ++ N + S+ P F+ Sbjct: 648 FNWTSLSFLPNLEVLDLAGNQLK-----ALTQGTLPNGTLLQKLDVSSNSIVSVVPAFFA 702 Query: 524 HLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFIC 583 L+ ++ LSHN IL P + + L+VLD+ N C Sbjct: 703 LAVELKEVN--------LSHN-------ILKTVDRSWFGP---IVMQLTVLDVRSNPLHC 744 Query: 584 ECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEE 632 C + F++ L + G + C P G S+F+ C +E Sbjct: 745 ACG-AAFVDLLLEVQTKVPGLANGVKCGSPGQLQGRSIFAQDLRLCLDE 792 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 95/401 (23%), Positives = 156/401 (38%), Gaps = 81/401 (20%) Query: 273 NIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFET------LKDLKVLNLAYNKINK 326 NI D N+ AGL V +D + + V T L L L+L YN + K Sbjct: 133 NILVLDANSLAGLYSLRVLFMDGNCYYKNPCTGAVKVTPGALLGLSQLTHLSLKYNNLTK 192 Query: 327 IADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKN-----HIA-------- 373 + + L+ L V SYNL+ +L + L + +D+ N H Sbjct: 193 VPRQLPPSLEYLLV---SYNLIVKLGPEDLAQLTSLRVLDVGGNCRRCDHAPNPCIECGQ 249 Query: 374 ---IIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHL 430 + +TF L L+ L L+D++L T++ + G LV L ++L+ N ++ Sbjct: 250 KSLHLHPETFHHLSHLEGLVLKDSSLHTLN------SSWFQG--LVQLSVLDLSENFLYE 301 Query: 431 S---ENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQL 487 S N +NL LR +L + F+ + SL++L + +L Sbjct: 302 SITHTNAFQNLT----RLRKLNLSFNYRKKVSFARLHLASSFKNLVSLQELNMNGIFFRL 357 Query: 488 AWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLT-------- 539 + L W L L L+L N++N +F ALR + L+ NR++ Sbjct: 358 LNKYTLRW--LADLPKLHTLHLQMNFINQAQLSIFGTFRALRFVDLSDNRISGPSTLSEA 415 Query: 540 ------------VLSHNDLPANLE----------------ILDISRNQLLAPNPDVFVSL 571 +LS + PA L +D+SRN L+ P++FV L Sbjct: 416 TPEEADDAEQEELLSADPHPAPLSTPASKNFMDRCKNFKFTMDLSRNNLVTIKPEMFVQL 475 Query: 572 S---VLDITHNKFICECELSTFINWLNHTNVTIAGPPADIY 609 S L ++HN S F+ N + ++ D+Y Sbjct: 476 SRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLY 516 Score = 36.6 bits (83), Expect = 0.048, Method: Compositional matrix adjust. Identities = 64/275 (23%), Positives = 102/275 (37%), Gaps = 82/275 (29%) Query: 313 DLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHI 372 ++ L+L N+I+ + + F L NL+ LNL +N P L + Sbjct: 43 NITRLSLISNRIHHLHNSDFVHLSNLRQLNLKWN------------CPPTGLSPLHFSCH 90 Query: 373 AIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSE 432 I+ +TF + L+ L+L N +TT+ +PS +L++LS Sbjct: 91 MTIEPRTFLAMRTLEELNLSYNGITTVPRLPS---------------------SLVNLS- 128 Query: 433 NRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETE 492 + H IL+L+ N + SL LF+ N + Sbjct: 129 --------------LSHTNILVLDANSLAGLY---------SLRVLFMDGN----CYYKN 161 Query: 493 LCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEI 552 C + + PG L+ L LSL N LT + LP +LE Sbjct: 162 PCTGAVK-----------------VTPGALLGLSQLTHLSLKYNNLTKVPR-QLPPSLEY 203 Query: 553 LDISRNQLLAPNPD---VFVSLSVLDITHNKFICE 584 L +S N ++ P+ SL VLD+ N C+ Sbjct: 204 LLVSYNLIVKLGPEDLAQLTSLRVLDVGGNCRRCD 238 Score = 33.5 bits (75), Expect = 0.43, Method: Compositional matrix adjust. Identities = 61/242 (25%), Positives = 93/242 (38%), Gaps = 41/242 (16%) Query: 301 FSLNSRVFETLKDLKVLNLAYNKINKI----ADEAFYGLDNLQVLNLSYNLLGELYSSNF 356 ++ R F ++ L+ LNL+YN I + + L + +L L N L LYS Sbjct: 91 MTIEPRTFLAMRTLEELNLSYNGITTVPRLPSSLVNLSLSHTNILVLDANSLAGLYSLRV 150 Query: 357 YGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI--HFIPSIPDIFLSGNK 414 + Y + L +L L L+ N LT + PS+ + +S N Sbjct: 151 LFMDGNCYYKNPCTGAVKVTPGALLGLSQLTHLSLKYNNLTKVPRQLPPSLEYLLVSYNL 210 Query: 415 LVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPS 474 +V L +L ++ L++L + N C D P NP Sbjct: 211 IVKLGPEDLA---------------------QLTSLRVLDVGGN-CRRC--DHAP--NPC 244 Query: 475 LEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLN 534 +E G+ L L ET F LSHL+ L L + L++L F L L L L+ Sbjct: 245 IE---CGQKSLHLHPET------FHHLSHLEGLVLKDSSLHTLNSSWFQGLVQLSVLDLS 295 Query: 535 SN 536 N Sbjct: 296 EN 297 >1XCD-A nrPDB Length = 329 Score = 58.2 bits (139), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 74/279 (26%), Positives = 119/279 (42%), Gaps = 67/279 (24%) Query: 293 LDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGEL- 351 LDL + + + F+ LK+L L L NKI+KI+ AF L L+ L LS N L EL Sbjct: 57 LDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELP 116 Query: 352 --------------------YSSNFYGLPKVAYIDLQKNHI--AIIQDQTFKFLEKLQTL 389 S F GL ++ ++L N + + I++ F+ ++KL + Sbjct: 117 EKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYI 176 Query: 390 DLRDNALTTI--HFIPSIPDIFLSGNKLVTLPKINLTA--NL--IHLSENRLENLDILYF 443 + D +TTI PS+ ++ L GNK+ + +L NL + LS N + +D Sbjct: 177 RIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDN-GS 235 Query: 444 LLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSH 503 L PHL+ L LN N+ G + Sbjct: 236 LANTPHLRELHLNNNKLVKVPGG-------------------------------LADHKY 264 Query: 504 LQVLYLNHNYLNSL------PPGVFSHLTALRGLSLNSN 536 +QV+YL++N ++++ PPG + + G+SL SN Sbjct: 265 IQVVYLHNNNISAIGSNDFCPPGYNTKKASYSGVSLFSN 303 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 75/287 (26%), Positives = 122/287 (42%), Gaps = 59/287 (20%) Query: 360 PKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIH---FIP--SIPDIFLSGNK 414 P A +DLQ N I I+D FK L+ L TL L +N ++ I F P + ++LS N+ Sbjct: 52 PDTALLDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQ 111 Query: 415 LVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPS 474 L LP E + LRV +I + ++ F+ Sbjct: 112 LKELP----------------EKMPKTLQELRVHENEITKVRKSVFN------------G 143 Query: 475 LEQLF---LGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGL 531 L Q+ LG N L+ + + F+G+ L + + + ++P G+ LT L Sbjct: 144 LNQMIVVELGTNPLK---SSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELH-- 198 Query: 532 SLNSNRLTVLSHNDLPA--NLEILDISRNQLLAPNPDVFVS---LSVLDITHNKFI-CEC 585 L+ N++T + L NL L +S N + A + + L L + +NK + Sbjct: 199 -LDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPG 257 Query: 586 ELSTF----INWLNHTNVTIAG-----PPADIYCVYPDSFSGVSLFS 623 L+ + +L++ N++ G PP Y S+SGVSLFS Sbjct: 258 GLADHKYIQVVYLHNNNISAIGSNDFCPPG--YNTKKASYSGVSLFS 302 Score = 32.0 bits (71), Expect = 1.2, Method: Compositional matrix adjust. Identities = 38/145 (26%), Positives = 64/145 (44%), Gaps = 29/145 (20%) Query: 38 LTQVPQVLNTT-ERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLT---IDKEAFRN 93 L ++P+ + T + L + N I V S F L Q+ ++ELG+ PL I+ AF+ Sbjct: 112 LKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGT--NPLKSSGIENGAFQG 169 Query: 94 L---------------------PNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLS 132 + P+L L L +KI + + +GL +L +L L F +S Sbjct: 170 MKKLSYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSIS 229 Query: 133 DAVLKDGYFRNLKALTRLDLSKNQI 157 + +G N L L L+ N++ Sbjct: 230 --AVDNGSLANTPHLRELHLNNNKL 252 Score = 32.0 bits (71), Expect = 1.3, Method: Compositional matrix adjust. Identities = 60/249 (24%), Positives = 101/249 (40%), Gaps = 36/249 (14%) Query: 136 LKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQG 195 +KDG F+NLK L L L N+I + +F L L+ + S NQ+ EL Sbjct: 67 IKDGDFKNLKNLHTLILINNKISKISPG-AFAPLVKLERLYLSKNQL-----KELPEKMP 120 Query: 196 KTLSFFSLAANSLYS-RVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQ 254 KTL + N + R SV N M+ ++++ N + +G + A + Sbjct: 121 KTLQELRVHENEITKVRKSV-----FNGLNQMI--VVELGTN--PLKSSGIENGAFQGMK 171 Query: 255 AFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDL 314 S I I D + T S+ L L + +++ + L +L Sbjct: 172 KLSYI-------------RIADTNITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNL 218 Query: 315 KVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYID---LQKNH 371 L L++N I+ + + + +L+ L+L+ N L ++ GL YI L N+ Sbjct: 219 AKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPG----GLADHKYIQVVYLHNNN 274 Query: 372 IAIIQDQTF 380 I+ I F Sbjct: 275 ISAIGSNDF 283 >2FT3-A nrPDB Length = 332 Score = 55.8 bits (133), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 69/261 (26%), Positives = 117/261 (44%), Gaps = 44/261 (16%) Query: 293 LDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELY 352 LDL + + L F+ L+ L L L NKI+KI ++AF L LQ L +S N L E+ Sbjct: 59 LDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIP 118 Query: 353 SSNFYGLP-KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPD---- 407 + LP + + + N I + F L + +++ N L F P D Sbjct: 119 PN----LPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKL 174 Query: 408 --IFLSGNKLVTLPK-INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCS 464 + +S KL +PK + T N +HL N+++ +++ L R+S Sbjct: 175 NYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLL--------------RYS--- 217 Query: 465 GDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSH 524 L +L LG N +++ L + L L+ L+L++N L+ +P G+ Sbjct: 218 ---------KLYRLGLGHNQIRMIENGSLSF-----LPTLRELHLDNNKLSRVPAGL-PD 262 Query: 525 LTALRGLSLNSNRLTVLSHND 545 L L+ + L++N +T + ND Sbjct: 263 LKLLQVVYLHTNNITKVGVND 283 Score = 47.0 bits (110), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 95/207 (45%), Gaps = 33/207 (15%) Query: 360 PKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIH---FIP--SIPDIFLSGNK 414 P +DLQ N I+ ++ FK L+ L L L +N ++ IH F P + +++S N Sbjct: 54 PDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNH 113 Query: 415 LVTLPKINLTANLIHLS--ENRLENLDILYF--LLRVPHLQI-----------------L 453 LV +P NL ++L+ L +NR+ + F L + +++ L Sbjct: 114 LVEIPP-NLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGL 172 Query: 454 ILNQNRFSSCSGDQTPSENP-SLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHN 512 LN R S P + P +L +L L N +Q A E E D+ S L L L HN Sbjct: 173 KLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQ-AIELE---DLLR-YSKLYRLGLGHN 227 Query: 513 YLNSLPPGVFSHLTALRGLSLNSNRLT 539 + + G S L LR L L++N+L+ Sbjct: 228 QIRMIENGSLSFLPTLRELHLDNNKLS 254 Score = 36.6 bits (83), Expect = 0.050, Method: Compositional matrix adjust. Identities = 34/131 (25%), Positives = 53/131 (40%), Gaps = 23/131 (17%) Query: 491 TELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANL 550 +EL D F+GL HL L L +N ++ + FS L L+ L ++ N L ++P NL Sbjct: 67 SELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLV-----EIPPNL 121 Query: 551 EILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYC 610 P V L + H+ I + F N + + G P + Sbjct: 122 --------------PSSLVELRI----HDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSG 163 Query: 611 VYPDSFSGVSL 621 P +F G+ L Sbjct: 164 FEPGAFDGLKL 174 Score = 35.0 bits (79), Expect = 0.14, Method: Compositional matrix adjust. Identities = 67/276 (24%), Positives = 114/276 (41%), Gaps = 38/276 (13%) Query: 69 LEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYF 128 L +Q +LG + P I P+ +LDL ++ I L D F+GL HL+ L L Sbjct: 35 LRVVQCSDLGLKAVPKEIS-------PDTTLLDLQNNDISELRKDDFKGLQHLYALVLVN 87 Query: 129 CGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEH 188 +S + + F L+ L +L +SKN + + + P+ +SL + N+I V + Sbjct: 88 NKISK--IHEKAFSPLRKLQKLYISKNHL--VEIPPNLP--SSLVELRIHDNRIRKVPKG 141 Query: 189 ELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSG---NGWTVDITGN 245 L + ++ + N L + G F + L L +S G D+ Sbjct: 142 VFSGL--RNMNCIEMGGNPLE-----NSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPET 194 Query: 246 FS------NAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGF 299 + N I + L+ + G G + I+ + + + L ++R L L + Sbjct: 195 LNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLP--TLRELHLDNNK 252 Query: 300 VFSLNSRVFETLKDLKVLNLAY---NKINKIADEAF 332 + SRV L DLK+L + Y N I K+ F Sbjct: 253 L----SRVPAGLPDLKLLQVVYLHTNNITKVGVNDF 284 >5YQ5-A nrPDB Length = 430 Score = 55.1 bits (131), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 67/249 (26%), Positives = 104/249 (41%), Gaps = 39/249 (15%) Query: 248 NAISKSQAFSLILAHHIMGAGFGFHNIKDP--DQNTFAGLARSSVRHLDLSHGFVFSLNS 305 N I A S I A H+ + IK D FA L ++ L L H +L Sbjct: 99 NEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLP--NLLQLHLEHN---NLEE 153 Query: 306 RVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGE--------------- 350 F K L+ L L YN+I+K+ A GL NL +L+L YN L + Sbjct: 154 FPFPLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDKIFAKMEKLM 213 Query: 351 ---LYSSNFYGLP-----KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHF- 401 L S+ +P + Y+ L+ N I+ I ++ F L KL TL + N L I + Sbjct: 214 QLNLCSNRLESMPPGLPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIPYN 273 Query: 402 ---IPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFL-----LRVPHLQIL 453 +P+I ++ + NKL I ++L N +E +++ L HL + Sbjct: 274 IFNLPNIVELSVGHNKLKQAFYIPRNLEHLYLQNNEIEKMNLTVMCPSIDPLHYHHLTYI 333 Query: 454 ILNQNRFSS 462 ++QN+ Sbjct: 334 RVDQNKLKE 342 Score = 49.3 bits (116), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 44/146 (30%), Positives = 68/146 (46%), Gaps = 24/146 (16%) Query: 38 LTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELG-SQYTPLTIDKEAFRNLPN 96 L +P + ++L L FN I VTA+SF L+ + L ++ ID F LPN Sbjct: 81 LKTIPNIPMHIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPN 140 Query: 97 L----------------------RILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDA 134 L R+L LG ++I L +A GL +L L L + L D+ Sbjct: 141 LLQLHLEHNNLEEFPFPLPKSLERLL-LGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDS 199 Query: 135 VLKDGYFRNLKALTRLDLSKNQIRSL 160 +LKD F ++ L +L+L N++ S+ Sbjct: 200 LLKDKIFAKMEKLMQLNLCSNRLESM 225 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 58/241 (24%), Positives = 106/241 (43%), Gaps = 42/241 (17%) Query: 290 VRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKI--NKIADEAFYGLDNLQVLNLS--- 344 ++ L L + ++ + F LK +NL++NKI KI F L NL L+L Sbjct: 91 IQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHLEHNN 150 Query: 345 ------------------YNLLGELYSSNFYGLPKVAYIDLQKN--HIAIIQDQTFKFLE 384 YN + +L ++ GL + +DL N H ++++D+ F +E Sbjct: 151 LEEFPFPLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDKIFAKME 210 Query: 385 KLQTLDLRDNALTTIHFIPSIPD----IFLSGNKLVTLPKINLTA----NLIHLSENRLE 436 KL L+L N L ++ P +P + L N + ++P+ + + +S N+L+ Sbjct: 211 KLMQLNLCSNRLESM--PPGLPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQ 268 Query: 437 NLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWD 496 DI Y + +P++ L + N+ P +LE L+L N ++ T +C Sbjct: 269 --DIPYNIFNLPNIVELSVGHNKLKQAF--YIPR---NLEHLYLQNNEIEKMNLTVMCPS 321 Query: 497 V 497 + Sbjct: 322 I 322 Score = 33.5 bits (75), Expect = 0.46, Method: Compositional matrix adjust. Identities = 59/249 (23%), Positives = 110/249 (44%), Gaps = 31/249 (12%) Query: 314 LKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLG--ELYSSNFYGLPKVAYIDLQKNH 371 ++ L L +N+I + +F +L+ +NLS+N + ++ F LP + + L+ N+ Sbjct: 91 IQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHLEHNN 150 Query: 372 IAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLS 431 +++ F + L+ L L N ++ + + + LV L ++L N +H Sbjct: 151 ---LEEFPFPLPKSLERLLLGYNEISKLQTN--------AMDGLVNLTMLDLCYNYLH-- 197 Query: 432 ENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWET 491 ++L ++ L L L NR S P SL L L N + + Sbjct: 198 ----DSLLKDKIFAKMEKLMQLNLCSNRLESMP----PGLPSSLMYLSLENNSI-----S 244 Query: 492 ELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLE 551 + F+ L L L ++HN L +P +F+ L + LS+ N+L + +P NLE Sbjct: 245 SIPEKYFDKLPKLHTLRMSHNKLQDIPYNIFN-LPNIVELSVGHNKLKQAFY--IPRNLE 301 Query: 552 ILDISRNQL 560 L + N++ Sbjct: 302 HLYLQNNEI 310 >2XOT-A nrPDB Length = 361 Score = 53.9 bits (128), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 51/159 (32%), Positives = 77/159 (48%), Gaps = 15/159 (9%) Query: 293 LDLSHGFVFSLNSRVFET-LKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGEL 351 LDLSH + L + T L +L L L++N +N I+ EAF + NL+ L+LS N L L Sbjct: 44 LDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHLHTL 103 Query: 352 YSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI--------HFIP 403 F L + + L NHI ++ F+ + +LQ L L N ++ + +P Sbjct: 104 DEFLFSDLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNQISRFPVELIKDGNKLP 163 Query: 404 SIPDIFLSGNKLVTLPKINL------TANLIHLSENRLE 436 + + LS NKL LP +L N ++L N LE Sbjct: 164 KLMLLDLSSNKLKKLPLTDLQKLPAWVKNGLYLHNNPLE 202 Score = 43.9 bits (102), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 52/149 (34%), Positives = 70/149 (46%), Gaps = 7/149 (4%) Query: 38 LTQVPQVLNTTERLL-LSFNYIRTVTASSFPF-LEQLQLLELGSQYTPLTIDKEAFRNLP 95 L VPQ L + LL LS N + + A P L L L L + I EAF +P Sbjct: 30 LPNVPQSLPSYTALLDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHLNF-ISSEAFVPVP 88 Query: 96 NLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKN 155 NLR LDL S+ ++ L F L L L LY + V+ F ++ L +L LS+N Sbjct: 89 NLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHI--VVVDRNAFEDMAQLQKLYLSQN 146 Query: 156 QIR--SLYLHPSFGKLNSLKSIDFSSNQI 182 QI + L KL L +D SSN++ Sbjct: 147 QISRFPVELIKDGNKLPKLMLLDLSSNKL 175 Score = 35.0 bits (79), Expect = 0.13, Method: Compositional matrix adjust. Identities = 28/87 (32%), Positives = 44/87 (50%), Gaps = 3/87 (3%) Query: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348 ++R+LDLS + +L+ +F L+ L+VL L N I + AF + LQ L LS N + Sbjct: 89 NLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNQI 148 Query: 349 GEL---YSSNFYGLPKVAYIDLQKNHI 372 + LPK+ +DL N + Sbjct: 149 SRFPVELIKDGNKLPKLMLLDLSSNKL 175 Score = 35.0 bits (79), Expect = 0.14, Method: Compositional matrix adjust. Identities = 60/246 (24%), Positives = 98/246 (39%), Gaps = 41/246 (16%) Query: 402 IPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYF------------LLRVPH 449 +P++P S L+ L NL+ + RL NL L + VP+ Sbjct: 30 LPNVPQSLPSYTALLDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHLNFISSEAFVPVPN 89 Query: 450 LQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYL 509 L+ L L+ N + + S+ +LE L L N + + + FE ++ LQ LYL Sbjct: 90 LRYLDLSSNHLHTLD-EFLFSDLQALEVLLLYNNHIVVVDR-----NAFEDMAQLQKLYL 143 Query: 510 NHNYLNSLPPGVF---SHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPD 566 + N ++ P + + L L L L+SN+L L DL ++ +N L N Sbjct: 144 SQNQISRFPVELIKDGNKLPKLMLLDLSSNKLKKLPLTDLQ---KLPAWVKNGLYLHN-- 198 Query: 567 VFVSLSVLDITHNKFICECEL-STFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLS 625 N C+C+L F +W ++ D+YC++ + FSL Sbjct: 199 ------------NPLECDCKLYQLFSHWQYRQLSSVMDFQEDLYCMHSKKLHNI--FSLD 244 Query: 626 TEGCDE 631 C E Sbjct: 245 FFNCSE 250 >4QDH-A nrPDB Length = 438 Score = 52.4 bits (124), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 80/279 (28%), Positives = 119/279 (42%), Gaps = 39/279 (13%) Query: 288 SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNL 347 SS L+L + SL VF+ L L L+L+ N + I E F L LQ L+LS+N Sbjct: 35 SSATRLELESNKLQSLPHGVFDKLTQLTKLSLSRNNLVTIKPEMFVNLSRLQCLSLSHNS 94 Query: 348 LGE-LYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIP 406 + + + S F L + +DL N + + ++F L +LQ LDL N + + I Sbjct: 95 IAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYN--SQPFSMKGIG 152 Query: 407 DIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGD 466 F L L ++L N IH + N + + FL Sbjct: 153 HNFSFVTHLSMLQSLSLAHNDIHTRVSSHLNSNSVRFL---------------------- 190 Query: 467 QTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSL-PPGVFSHL 525 F G M ++ E L F+GLS L L L+ N L+ L P + + Sbjct: 191 -----------DFSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQNLDNLP 239 Query: 526 TALRGLSLNSNRLTVLSHNDLP--ANLEILDISRNQLLA 562 +L+ LSL N L+ + L NLE+LD++ NQL A Sbjct: 240 KSLKLLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKA 278 Score = 39.7 bits (91), Expect = 0.006, Method: Compositional matrix adjust. Identities = 46/168 (27%), Positives = 72/168 (42%), Gaps = 7/168 (4%) Query: 20 GIPSCSFDGRIAFYRFCNLTQ-VPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELG 78 GIPS + + + +L V L +L LS N + T+ F L +LQ L L Sbjct: 32 GIPSSATRLELESNKLQSLPHGVFDKLTQLTKLSLSRNNLVTIKPEMFVNLSRLQCLSLS 91 Query: 79 SQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKD 138 ++ F L NL++LDL +K+ H +F L L L L + ++ Sbjct: 92 HNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYNSQPFSMKGI 151 Query: 139 G----YFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQI 182 G + +L L L L+ N I + S NS++ +DFS N + Sbjct: 152 GHNFSFVTHLSMLQSLSLAHNDIHTRV--SSHLNSNSVRFLDFSGNGM 197 Score = 34.3 bits (77), Expect = 0.25, Method: Compositional matrix adjust. Identities = 70/296 (23%), Positives = 124/296 (41%), Gaps = 73/296 (24%) Query: 285 LARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN----KINKIADEAFY--GLDNL 338 L ++++ LDLSH + + + F L L+ L+L+YN + I + L L Sbjct: 105 LPLTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYNSQPFSMKGIGHNFSFVTHLSML 164 Query: 339 QVLNLSYNLL-----------------------------GELYSSNFYGLPKVAYIDLQK 369 Q L+L++N + G LY F GL + +DL + Sbjct: 165 QSLSLAHNDIHTRVSSHLNSNSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQ 224 Query: 370 NHIAIIQDQTF-KFLEKLQTLDLRDNAL-----TTIHFIPSIPDIFLSGNKLVTLPKINL 423 N++ I++ Q + L+ L LRDN L T++ F+P++ + L+GN+L L L Sbjct: 225 NNLHILRPQNLDNLPKSLKLLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTNGTL 284 Query: 424 TANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGEN 483 + L+ LD+ + L L+++ L N Sbjct: 285 PNGTL------LQKLDVSSNSIVSVVPAFFALAV----------------ELKEVNLSHN 322 Query: 484 MLQL---AWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSN 536 +L+ +W + ++ E L L+ N L S+P G+F LT+L+ + L++N Sbjct: 323 ILKTVDRSWFGPIVMNLKE-------LALDTNQLKSVPDGIFDRLTSLQKIWLHTN 371 >2Z80-A nrPDB Length = 353 Score = 50.4 bits (119), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 69/269 (25%), Positives = 127/269 (47%), Gaps = 20/269 (7%) Query: 283 AGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLN 342 +GL + V+ LDLS+ + +++ + +L+ L L N IN I +++F L +L+ L+ Sbjct: 48 SGLTEA-VKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLD 106 Query: 343 LSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQT-FKFLEKLQTLDLRD-NALTTIH 400 LSYN L L SS F L + +++L N + + + F L KLQ L + + + T I Sbjct: 107 LSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQ 166 Query: 401 F-----IPSIPDIFLSGNKLVTLPKINLTA--NLIHLSENRLENLDILYFLLRVP----- 448 + + ++ + + L + +L + N+ HL + +++ +L + V Sbjct: 167 RKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVEC 226 Query: 449 -HLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVL 507 L+ L+ FS S +T S L + F N+ + +S L L Sbjct: 227 LELRDTDLDTFHFSELSTGETNS----LIKKFTFRNVKITDESLFQVMKLLNQISGLLEL 282 Query: 508 YLNHNYLNSLPPGVFSHLTALRGLSLNSN 536 + N L S+P G+F LT+L+ + L++N Sbjct: 283 EFSRNQLKSVPDGIFDRLTSLQKIWLHTN 311 Score = 41.2 bits (95), Expect = 0.002, Method: Compositional matrix adjust. Identities = 46/189 (24%), Positives = 85/189 (44%), Gaps = 31/189 (16%) Query: 239 TVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHG 298 ++D++ N IS S + ++ G + I ++++F+ L S+ HLDLS+ Sbjct: 56 SLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTI---EEDSFSSLG--SLEHLDLSYN 110 Query: 299 FVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYG-LDNLQVLNL-SYNLLGELYSSNF 356 ++ +L+S F+ L L LNL N + + + + L LQ+L + + + ++ +F Sbjct: 111 YLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDF 170 Query: 357 YGLP-----KVAYIDLQK------------NHIAIIQDQTFKFLE-------KLQTLDLR 392 GL ++ DLQ +H+ + Q LE ++ L+LR Sbjct: 171 AGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELR 230 Query: 393 DNALTTIHF 401 D L T HF Sbjct: 231 DTDLDTFHF 239 Score = 39.7 bits (91), Expect = 0.006, Method: Compositional matrix adjust. Identities = 30/102 (29%), Positives = 50/102 (49%) Query: 298 GFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFY 357 G SLNS + +K L+L+ N+I I++ NLQ L L+ N + + +F Sbjct: 38 GSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFS 97 Query: 358 GLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI 399 L + ++DL N+++ + FK L L L+L N T+ Sbjct: 98 SLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTL 139 Score = 34.3 bits (77), Expect = 0.24, Method: Compositional matrix adjust. Identities = 25/71 (35%), Positives = 42/71 (59%), Gaps = 8/71 (11%) Query: 514 LNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLP--ANLEILDISRNQLLAPNPDVFVSL 571 LNS+P G+ A++ L L++NR+T +S++DL NL+ L ++ N + D F SL Sbjct: 43 LNSIPSGLTE---AVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSL 99 Query: 572 SV---LDITHN 579 LD+++N Sbjct: 100 GSLEHLDLSYN 110 Score = 32.3 bits (72), Expect = 0.89, Method: Compositional matrix adjust. Identities = 28/84 (33%), Positives = 43/84 (51%), Gaps = 3/84 (3%) Query: 45 LNTTERLLLSFNYIRTVTASSFPFLEQLQLLE-LGSQYTPLTIDKEAFRNLPNLRILDLG 103 L + E L LS+NY+ +++S F L L L LG+ Y L + F +L L+IL +G Sbjct: 99 LGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLG-ETSLFSHLTKLQILRVG 157 Query: 104 SSKIYF-LHPDAFQGLFHLFELRL 126 + + + F GL L EL + Sbjct: 158 NMDTFTKIQRKDFAGLTFLEELEI 181 >3A7C-A nrPDB Length = 580 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 47/153 (30%), Positives = 72/153 (47%), Gaps = 9/153 (5%) Query: 240 VDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGF 299 V IT FS S ++ S + G F +I +GL ++++ LDLS Sbjct: 12 VAITVLFSKRCSAQESLSCDASGVCDGRSRSFTSIP-------SGLT-AAMKSLDLSFNK 63 Query: 300 VFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGL 359 + + +L+VL L ++IN I +AFY L +L+ L+LS N L L SS F L Sbjct: 64 ITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHLSSLSSSWFGPL 123 Query: 360 PKVAYIDLQKNHIAIIQDQT-FKFLEKLQTLDL 391 + Y++L N + + F L LQTL + Sbjct: 124 SSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRI 156 Score = 47.0 bits (110), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 28/95 (29%), Positives = 46/95 (48%) Query: 314 LKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIA 373 +K L+L++NKI I NLQVL L + + + FY L + ++DL NH++ Sbjct: 54 MKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHLS 113 Query: 374 IIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDI 408 + F L L+ L+L N T+ P++ Sbjct: 114 SLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNL 148 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 116/499 (23%), Positives = 212/499 (42%), Gaps = 71/499 (14%) Query: 45 LNTTERLLLSFNYIRTVTASSFPFLEQLQLLEL-GSQYTPLTIDKEAFRNLPNLRILDLG 103 L + E L LS N++ ++++S F L L+ L L G+ Y L + F NL NL+ L +G Sbjct: 99 LGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGV-TSLFPNLTNLQTLRIG 157 Query: 104 SSKIYF-LHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYL 162 + + + + F GL L EL + L + + ++++ + L L ++ S +L Sbjct: 158 NVETFSEIRRIDFAGLTSLNELEIKALSLRN--YQSQSLKSIRDIHHLTLHLSE--SAFL 213 Query: 163 HPSFGK-LNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMN 221 F L+S++ ++ + + PL +S L R SV + N Sbjct: 214 LEIFADILSSVRYLELRDTNL---ARFQFSPLPVDEVSS---PMKKLAFRGSVLTDESFN 267 Query: 222 PFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNT 281 ++ IL++S + D T N G G N + D + Sbjct: 268 ELLKLLRYILELSEVEFD-DCTLN----------------------GLGDFNPSESDVVS 304 Query: 282 FAGLARS-SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQV 340 G + ++R L + ++F S V+ L+ +K + + +K+ + L +L+ Sbjct: 305 ELGKVETVTIRRLHIPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEF 364 Query: 341 LNLSYNLLGELYSSNFY---GLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALT 397 L+LS NL+ E Y N P + + L +NH+ +Q +T + L L+ L D + Sbjct: 365 LDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQ-KTGEILLTLKNLTSLDISRN 423 Query: 398 TIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQ 457 T H +PD K+ L NL++ I + + + L++L ++ Sbjct: 424 TFH---PMPDSCQWPEKMRFL---NLSSTGIRVVKTCIPQ-----------TLEVLDVSN 466 Query: 458 NRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSL 517 N S S P L++L++ N L+ + L L V+ + N L S+ Sbjct: 467 NNLDSFSLFL-----PRLQELYISRNKLKTLPDASL-------FPVLLVMKIASNQLKSV 514 Query: 518 PPGVFSHLTALRGLSLNSN 536 P G+F LT+L+ + L++N Sbjct: 515 PDGIFDRLTSLQKIWLHTN 533 Score = 30.8 bits (68), Expect = 2.5, Method: Compositional matrix adjust. Identities = 20/62 (32%), Positives = 36/62 (58%), Gaps = 5/62 (8%) Query: 516 SLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPA--NLEILDISRNQLLAPNPDVFVSLSV 573 S+P G+ + A++ L L+ N++T + H DL A NL++L + +++ D F SL Sbjct: 45 SIPSGLTA---AMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGS 101 Query: 574 LD 575 L+ Sbjct: 102 LE 103 Score = 30.8 bits (68), Expect = 2.6, Method: Compositional matrix adjust. Identities = 29/100 (29%), Positives = 49/100 (49%), Gaps = 10/100 (10%) Query: 461 SSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPG 520 S+C G PSL+ L L +N L+ +T ++ L +L L ++ N + +P Sbjct: 380 SACKGAW-----PSLQTLVLSQNHLRSMQKTG---EILLTLKNLTSLDISRNTFHPMPDS 431 Query: 521 VFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQL 560 +R L+L+S + V+ +P LE+LD+S N L Sbjct: 432 C-QWPEKMRFLNLSSTGIRVV-KTCIPQTLEVLDVSNNNL 469 >2V9T-B nrPDB Length = 220 Score = 47.8 bits (112), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 35/111 (31%), Positives = 56/111 (50%) Query: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348 ++ + L + + F K L+ ++L+ N+I+++A +AF GL +L L L N + Sbjct: 33 TITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKI 92 Query: 349 GELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI 399 EL S F GL + + L N I ++ F+ L L L L DN L TI Sbjct: 93 TELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTI 143 Score = 45.4 bits (106), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 40/114 (35%), Positives = 57/114 (50%), Gaps = 8/114 (7%) Query: 491 TELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVL---SHNDLP 547 +EL D F+GL L L L N + LP +F L +L+ L LN+N++ L + DL Sbjct: 69 SELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDL- 127 Query: 548 ANLEILDISRNQLLAPNPDVFVSLSVLDITH---NKFICECELSTFINWLNHTN 598 NL +L + N+L F L + H N FIC+C L ++L HTN Sbjct: 128 HNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYL-HTN 180 Score = 41.2 bits (95), Expect = 0.002, Method: Compositional matrix adjust. Identities = 42/137 (30%), Positives = 61/137 (44%), Gaps = 5/137 (3%) Query: 80 QYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDG 139 Q T I AF LR +DL +++I L PDAFQGL L L LY G L Sbjct: 41 QNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLY--GNKITELPKS 98 Query: 140 YFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLS 199 F L +L L L+ N+I L + +F L++L + N++ + + PL + + Sbjct: 99 LFEGLFSLQLLLLNANKINCLRVD-AFQDLHNLNLLSLYDNKLQTIAKGTFSPL--RAIQ 155 Query: 200 FFSLAANSLYSRVSVDW 216 LA N + W Sbjct: 156 TMHLAQNPFICDCHLKW 172 Score = 39.7 bits (91), Expect = 0.006, Method: Compositional matrix adjust. Identities = 34/105 (32%), Positives = 51/105 (48%) Query: 290 VRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLG 349 +R +DLS+ + L F+ L+ L L L NKI ++ F GL +LQ+L L+ N + Sbjct: 58 LRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKIN 117 Query: 350 ELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDN 394 L F L + + L N + I TF L +QT+ L N Sbjct: 118 CLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQN 162 Score = 33.1 bits (74), Expect = 0.52, Method: Compositional matrix adjust. Identities = 19/64 (29%), Positives = 34/64 (53%), Gaps = 5/64 (7%) Query: 362 VAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI-----HFIPSIPDIFLSGNKLV 416 + I L++N I +I F +KL+ +DL +N ++ + + S+ + L GNK+ Sbjct: 34 ITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKIT 93 Query: 417 TLPK 420 LPK Sbjct: 94 ELPK 97 Score = 29.6 bits (65), Expect = 6.1, Method: Compositional matrix adjust. Identities = 15/52 (28%), Positives = 31/52 (59%), Gaps = 3/52 (5%) Query: 491 TELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLS 542 TE+ ++ E ++ ++ L N + +PPG FS LR + L++N+++ L+ Sbjct: 24 TEIPTNLPETITEIR---LEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELA 72 >5XJX-C nrPDB Length = 433 Score = 47.0 bits (110), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 70/231 (30%), Positives = 101/231 (43%), Gaps = 46/231 (19%) Query: 444 LLRVPHLQILILNQNRFSSCSGDQTPSENP--------SLEQLFLGENMLQLAWETELCW 495 L R+ HL+ L F C G + P P SL+ L L EN EL Sbjct: 101 LTRLKHLKALF-----FYRCLG-RAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELG- 153 Query: 496 DVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLT-VLSHNDLPANLEILD 554 L++L+VL L+ N+LN P F+ + LR L L+ NRLT + LPA L +LD Sbjct: 154 ----NLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPA-LSVLD 208 Query: 555 ISRNQLLAPNPDVFVSLSVL---DITHNKFICECELSTFINWLNH------TNVTIAGPP 605 +++N L P P S L D++ N+ S IN LN + ++GP Sbjct: 209 LNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPES--INRLNQLVLLDLSYNRLSGP- 265 Query: 606 ADIYCVYPDSFSGV-SLFSLSTEGCDE------EEVLKSLKFSLFIVCTVT 649 +P S G+ SL +L +G + E K LK + +V + T Sbjct: 266 ------FPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNT 310 Score = 34.7 bits (78), Expect = 0.18, Method: Compositional matrix adjust. Identities = 39/124 (31%), Positives = 53/124 (42%), Gaps = 3/124 (2%) Query: 89 EAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALT 148 E+ L L +LDL +++ P + QGL L L L + + F+ LK L Sbjct: 244 ESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLM 303 Query: 149 RLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSL 208 L LS I+ + S +LNSL+ + N L E LE K LS L NSL Sbjct: 304 ILVLSNTNIQG-SIPKSLTRLNSLRVLHLEGNN--LTGEIPLEFRDVKHLSELRLNDNSL 360 Query: 209 YSRV 212 V Sbjct: 361 TGPV 364 Score = 33.1 bits (74), Expect = 0.53, Method: Compositional matrix adjust. Identities = 52/215 (24%), Positives = 87/215 (40%), Gaps = 20/215 (9%) Query: 195 GKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQ 254 G +L L N + + G N L++LD+ N I +F N S + Sbjct: 131 GSSLQTLVLRENGFLGPIPDELGNLTN------LKVLDLHKNHLNGSIPLSF-NRFSGLR 183 Query: 255 AFSLILAHHIMGAGFGFH----NIKDPDQNTFAG------LARSSVRHLDLSHGFVFSLN 304 + L + + G+ GF ++ D +QN G + S+ +DLS V Sbjct: 184 SLDLS-GNRLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPI 242 Query: 305 SRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYN--LLGELYSSNFYGLPKV 362 L L +L+L+YN+++ + GL++LQ L L N + + F GL + Sbjct: 243 PESINRLNQLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNL 302 Query: 363 AYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALT 397 + L +I ++ L L+ L L N LT Sbjct: 303 MILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLT 337 >5D3I-A nrPDB Length = 568 Score = 46.6 bits (109), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 28/95 (29%), Positives = 46/95 (48%) Query: 314 LKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIA 373 +K L+L++NKI I NLQVL L + + + FY L + ++DL NH++ Sbjct: 32 MKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHLS 91 Query: 374 IIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDI 408 + F L L+ L+L N T+ P++ Sbjct: 92 SLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNL 126 Score = 45.4 bits (106), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 37/108 (34%), Positives = 57/108 (52%), Gaps = 2/108 (1%) Query: 283 AGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLN 342 +GL ++++ LDLS + + +L+VL L ++IN I +AFY L +L+ L+ Sbjct: 26 SGLT-AAMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEHLD 84 Query: 343 LSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQT-FKFLEKLQTL 389 LS N L L SS F L + Y++L N + + F L LQTL Sbjct: 85 LSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTL 132 Score = 43.1 bits (100), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 119/517 (23%), Positives = 214/517 (41%), Gaps = 79/517 (15%) Query: 45 LNTTERLLLSFNYIRTVTASSFPFLEQLQLLEL-GSQYTPLTIDKEAFRNLPNLRILDLG 103 L + E L LS N++ ++++S F L L+ L L G+ Y L + F NL NL+ L +G Sbjct: 77 LGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGV-TSLFPNLTNLQTLRIG 135 Query: 104 SSKIYF-LHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYL 162 + + + + F GL L EL + L + + ++++ + L L ++ S +L Sbjct: 136 NVETFSEIRRIDFAGLTSLNELEIKALSLRN--YQSQSLKSIRDIHHLTLHLSE--SAFL 191 Query: 163 HPSFGK-LNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMN 221 F L+S++ ++ + + PL +S L R SV + N Sbjct: 192 LEIFADILSSVRYLELRDTNL---ARFQFSPLPVDEVSS---PMKKLAFRGSVLTDESFN 245 Query: 222 PFRNM---VLEILDVSGNGWTVDITGNF----SNAISKSQAFSLILAHHIMGAGFGFHNI 274 + +LE+ +V + T++ G+F S+ +S+ + + F Sbjct: 246 ELLKLLRYILELSEVEFDDCTLNGLGDFNPSESDVVSELGKVETVTIRRLHIPQFYLFY- 304 Query: 275 KDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINK--IADEAF 332 D +T L V+ + + + VF + + LK L+ L+L+ N + + + + A Sbjct: 305 ---DLSTVYSLLEK-VKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSAC 360 Query: 333 YGL-DNLQVLNLSYNLLGELYSSN--FYGLPKVAYIDLQKNHIAIIQD-----QTFKFL- 383 G +LQ L LS N L + + L + +D+ +N + D + +FL Sbjct: 361 KGAWPSLQTLVLSQNHLRSMQKTGEILLTLKNLTSLDISRNTFHPMPDSCQWPEKMRFLN 420 Query: 384 --------------EKLQTLDLRDNALTTIH-FIPSIPDIFLSGNKLVTLPKINLTANLI 428 + L+ LD+ +N L + F+P + ++++S NKL TLP +L Sbjct: 421 LSSTGIRVVKTCIPQTLEVLDVSNNNLDSFSLFLPRLQELYISRNKLKTLPDASL----- 475 Query: 429 HLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLA 488 P L ++ + +N S+ S DQ S P LE L G+N Sbjct: 476 ------------------FPVLLVMKIRENAVSTFSKDQLGS-FPKLETLEAGDN--HFV 514 Query: 489 WETELCWDVFEGLSHLQVLY-LNHNYLNSLPPGVFSH 524 EL E + Q+L +YL PP + H Sbjct: 515 CSCELLSFTMETPALAQILVDWPDSYLCDSPPRLHGH 551 Score = 33.9 bits (76), Expect = 0.32, Method: Compositional matrix adjust. Identities = 35/117 (29%), Positives = 55/117 (47%), Gaps = 17/117 (14%) Query: 504 LQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAP 563 L+VL +++N L+S +F L L+ L ++ N+L L L L ++ I N + Sbjct: 437 LEVLDVSNNNLDSF--SLF--LPRLQELYISRNKLKTLPDASLFPVLLVMKIRENAVSTF 492 Query: 564 NPD---VFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPP-ADIYCVYPDSF 616 + D F L L+ N F+C CEL +F T+ P A I +PDS+ Sbjct: 493 SKDQLGSFPKLETLEAGDNHFVCSCELLSF---------TMETPALAQILVDWPDSY 540 Score = 32.0 bits (71), Expect = 1.3, Method: Compositional matrix adjust. Identities = 29/93 (31%), Positives = 45/93 (48%), Gaps = 2/93 (2%) Query: 91 FRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRL 150 R NL++L L SS+I + DAF L L L L LS L +F L +L L Sbjct: 50 LRACANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHLSS--LSSSWFGPLSSLKYL 107 Query: 151 DLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIF 183 +L N ++L + F L +L+++ + + F Sbjct: 108 NLMGNPYQTLGVTSLFPNLTNLQTLRIGNVETF 140 Score = 30.8 bits (68), Expect = 2.7, Method: Compositional matrix adjust. Identities = 20/62 (32%), Positives = 36/62 (58%), Gaps = 5/62 (8%) Query: 516 SLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPA--NLEILDISRNQLLAPNPDVFVSLSV 573 S+P G+ + A++ L L+ N++T + H DL A NL++L + +++ D F SL Sbjct: 23 SIPSGLTA---AMKSLDLSFNKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGS 79 Query: 574 LD 575 L+ Sbjct: 80 LE 81 >5MX0-A nrPDB Length = 362 Score = 45.1 bits (105), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 64/229 (27%), Positives = 103/229 (44%), Gaps = 31/229 (13%) Query: 288 SSVRHLD---LSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLS 344 S +RHL+ L H + + + +L++L +L +N+I+++ + A GL+NL L L Sbjct: 138 SKLRHLERLYLDHNNLTRMPGPLPRSLREL---HLDHNQISRVPNNALEGLENLTALYLQ 194 Query: 345 YNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPS 404 +N + E+ SS GL + +DL NH+ + D LE+L + N + T Sbjct: 195 HNEIQEVGSS-MRGLRSLILLDLSYNHLRKVPDGLPSALEQLY---MEHNNVYT------ 244 Query: 405 IPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCS 464 +PD + G PK+ + LS N L N + L L L+ N+ Sbjct: 245 VPDSYFRG-----APKL----LYVRLSHNSLTNNGLASNTFNSSSLLELDLSYNQLQ--- 292 Query: 465 GDQTPSENPSLEQLFLGENMLQLAWETELCWDV-FEGLSHLQVLYLNHN 512 + P N +LE L+L N + + C V S LQVL L+ N Sbjct: 293 --KIPPVNTNLENLYLQGNRINEFSISSFCTVVDVVNFSKLQVLRLDGN 339 Score = 33.5 bits (75), Expect = 0.41, Method: Compositional matrix adjust. Identities = 29/87 (33%), Positives = 48/87 (55%), Gaps = 7/87 (8%) Query: 497 VFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPA--NLEILD 554 VF L HL+ LYL+HN L + PG +LR L L+ N+++ + +N L NL L Sbjct: 136 VFSKLRHLERLYLDHNNLTRM-PGPLPR--SLRELHLDHNQISRVPNNALEGLENLTALY 192 Query: 555 ISRNQL--LAPNPDVFVSLSVLDITHN 579 + N++ + + SL +LD+++N Sbjct: 193 LQHNEIQEVGSSMRGLRSLILLDLSYN 219 >2Z7X-A nrPDB Length = 549 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 113/503 (22%), Positives = 199/503 (39%), Gaps = 108/503 (21%) Query: 96 NLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKN 155 NL+ L L S+ I + D+F L L L L + LS+ L +F+ L +LT L+L N Sbjct: 51 NLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSN--LSSSWFKPLSSLTFLNLLGN 108 Query: 156 QIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHE-------LEPLQGKTLSFFSLAANSL 208 ++L F L L+ + + F + + LE L+ S SL Sbjct: 109 PYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSL 168 Query: 209 YSRVSVDWGKCMNPFRNMVLEI-LDVSGNGWTVDI------TGNFSNAISKSQAFSLILA 261 S +V ++LEI +DV+ + +++ T +FS +S + SLI Sbjct: 169 KSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFS-ELSTGETNSLI-- 225 Query: 262 HHIMGAGFGFHNIKDPDQNTF------------------------AGLARSS-------- 289 F F N+K D++ F G R+S Sbjct: 226 -----KKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDP 280 Query: 290 -------VRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLN 342 +R L + ++F S ++ + +K + + +K+ + L +L+ L+ Sbjct: 281 GKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLD 340 Query: 343 LSYNLLGELYSSNFY---GLPKVAYIDLQKNHIAIIQD--QTFKFLEKLQTLDLRDNALT 397 LS NL+ E Y N P + + L++NH+A ++ +T L+ L +D+ N+ Sbjct: 341 LSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFH 400 Query: 398 TIHFIPSIPDIFLSGNKLVTLPKINLTANLIH----LSENRLENLDILYFLLRVPHLQIL 453 ++ P+ + +NL++ IH LE LD+ L + Sbjct: 401 SMPETCQWPE---------KMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNL------ 445 Query: 454 ILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNY 513 P L++L++ N L + L L L VL ++ N Sbjct: 446 --------------FSLNLPQLKELYISRNKLMTLPDASL-------LPMLLVLKISRNQ 484 Query: 514 LNSLPPGVFSHLTALRGLSLNSN 536 L S+P G+F LT+L+ + L++N Sbjct: 485 LKSVPDGIFDRLTSLQKIWLHTN 507 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 46/189 (24%), Positives = 85/189 (44%), Gaps = 31/189 (16%) Query: 239 TVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHG 298 ++D++ N IS S + ++ G + I ++++F+ L S+ HLDLS+ Sbjct: 30 SLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTI---EEDSFSSLG--SLEHLDLSYN 84 Query: 299 FVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYG-LDNLQVLNL-SYNLLGELYSSNF 356 ++ +L+S F+ L L LNL N + + + + L LQ+L + + + ++ +F Sbjct: 85 YLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDF 144 Query: 357 YGLP-----KVAYIDLQK------------NHIAIIQDQTFKFLE-------KLQTLDLR 392 GL ++ DLQ +H+ + Q LE ++ L+LR Sbjct: 145 AGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELR 204 Query: 393 DNALTTIHF 401 D L T HF Sbjct: 205 DTDLDTFHF 213 Score = 38.9 bits (89), Expect = 0.010, Method: Compositional matrix adjust. Identities = 30/102 (29%), Positives = 50/102 (49%) Query: 298 GFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFY 357 G SLNS + +K L+L+ N+I I++ NLQ L L+ N + + +F Sbjct: 12 GSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFS 71 Query: 358 GLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI 399 L + ++DL N+++ + FK L L L+L N T+ Sbjct: 72 SLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTL 113 Score = 35.8 bits (81), Expect = 0.091, Method: Compositional matrix adjust. Identities = 107/447 (23%), Positives = 189/447 (42%), Gaps = 84/447 (18%) Query: 45 LNTTERLLLSFNYIRTVTASSFPFLEQLQLLE-LGSQYTPLTIDKEAFRNLPNLRILDLG 103 L + E L LS+NY+ +++S F L L L LG+ Y L + F +L L+IL +G Sbjct: 73 LGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLG-ETSLFSHLTKLQILRVG 131 Query: 104 SSKIYF-LHPDAFQGLFHLFELRLYFCGLSDAVLKDGYF-RNLKALTRLDLSKNQIRSLY 161 + + + F GL L EL + DA Y ++LK++ + L Sbjct: 132 NMDTFTKIQRKDFAGLTFLEELEI------DASDLQSYEPKSLKSI-------QNVSHLI 178 Query: 162 LHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLA---ANSLYSRVSVDWGK 218 LH L +D +S+ L EL T F L+ NSL + + K Sbjct: 179 LHMKQHILLLEIFVDVTSSVECL----ELRDTDLDTFHFSELSTGETNSLIKKFTFRNVK 234 Query: 219 CMNPFRNMVLEILD-VSG------NGWTVDITGNF-----SNAISKSQAFSLILAHHIMG 266 + V+++L+ +SG + T++ GNF I + +L + + Sbjct: 235 ITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIP 294 Query: 267 AGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKI-- 324 + F+ D +T L V+ + + + VF + + + LK L+ L+L+ N + Sbjct: 295 RFYLFY-----DLSTLYSLTE-RVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVE 348 Query: 325 ----NKIADEAFYGLDNLQVLNLSYNLLGELYSS--NFYGLPKVAYIDLQKNHIAIIQDQ 378 N ++A+ +LQ L L N L L + L + ID+ KN + + Sbjct: 349 EYLKNSACEDAW---PSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMP-E 404 Query: 379 TFKFLEKLQTLDLRDNALTTIHFI-------------------------PSIPDIFLSGN 413 T ++ EK++ L+L + T IH + P + ++++S N Sbjct: 405 TCQWPEKMKYLNL---SSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRN 461 Query: 414 KLVTLPKINLTANL--IHLSENRLENL 438 KL+TLP +L L + +S N+L+++ Sbjct: 462 KLMTLPDASLLPMLLVLKISRNQLKSV 488 Score = 33.9 bits (76), Expect = 0.35, Method: Compositional matrix adjust. Identities = 25/71 (35%), Positives = 42/71 (59%), Gaps = 8/71 (11%) Query: 514 LNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLP--ANLEILDISRNQLLAPNPDVFVSL 571 LNS+P G+ A++ L L++NR+T +S++DL NL+ L ++ N + D F SL Sbjct: 17 LNSIPSGLTE---AVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSL 73 Query: 572 SV---LDITHN 579 LD+++N Sbjct: 74 GSLEHLDLSYN 84 >2JS7-A nrPDB Length = 160 Score = 42.7 bits (99), Expect = 6e-04, Method: Composition-based stats. Identities = 26/89 (29%), Positives = 44/89 (49%), Gaps = 7/89 (7%) Query: 681 DHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENR 740 D P G P+ ++DA++C+ D +VQ + + T Y R LC +RD +PG Sbjct: 7 DDPLGHMPE--RFDAFICYCPSDIQFVQEMIRQLEQTNY----RLKLCVSDRDVLPGTCV 60 Query: 741 IANIQDAIWNS-RKIVCLVSRHFLRDGWC 768 + + I R++V +VS +L+ C Sbjct: 61 WSIASELIEKRCRRMVVVVSDDYLQSKEC 89 >2Z7X-B nrPDB Length = 520 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 22/66 (33%), Positives = 37/66 (56%) Query: 340 VLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI 399 +LN+S N + EL++S+ L K+ + + N I + FKF ++L+ LDL N L I Sbjct: 25 ILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKI 84 Query: 400 HFIPSI 405 P++ Sbjct: 85 SCHPTV 90 Score = 33.5 bits (75), Expect = 0.46, Method: Compositional matrix adjust. Identities = 26/89 (29%), Positives = 50/89 (56%), Gaps = 4/89 (4%) Query: 285 LARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLS 344 L+ S +R L +SH + L+ VF+ ++L+ L+L++NK+ KI + + NL+ L+LS Sbjct: 42 LSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKI---SCHPTVNLKHLDLS 98 Query: 345 YNLLGEL-YSSNFYGLPKVAYIDLQKNHI 372 +N L F + ++ ++ L H+ Sbjct: 99 FNAFDALPICKEFGNMSQLKFLGLSTTHL 127 Score = 31.2 bits (69), Expect = 1.8, Method: Compositional matrix adjust. Identities = 25/78 (32%), Positives = 42/78 (53%), Gaps = 2/78 (2%) Query: 506 VLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPAN--LEILDISRNQLLAP 563 +L ++ NY++ L L+ LR L ++ NR+ L + N LE LD+S N+L+ Sbjct: 25 ILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKI 84 Query: 564 NPDVFVSLSVLDITHNKF 581 + V+L LD++ N F Sbjct: 85 SCHPTVNLKHLDLSFNAF 102 Score = 29.6 bits (65), Expect = 5.6, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 23/36 (63%) Query: 501 LSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSN 536 L LQ L + N L S+P G+F LT+L+ + L++N Sbjct: 443 LEALQELNVASNQLKSVPDGIFDRLTSLQKIWLHTN 478 Score = 28.9 bits (63), Expect = 9.8, Method: Compositional matrix adjust. Identities = 24/81 (29%), Positives = 41/81 (50%), Gaps = 6/81 (7%) Query: 478 LFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNR 537 L + +N + W +++ LS L++L ++HN + L VF L L L+ N+ Sbjct: 26 LNISQNYISELWTSDIL-----SLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNK 80 Query: 538 LTVLSHNDLPANLEILDISRN 558 L +S + NL+ LD+S N Sbjct: 81 LVKISCHP-TVNLKHLDLSFN 100 >6HKW-A nrPDB Length = 363 Score = 42.0 bits (97), Expect = 0.001, Method: Compositional matrix adjust. Identities = 65/229 (28%), Positives = 103/229 (44%), Gaps = 35/229 (15%) Query: 366 DLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTA 425 D+ NH I + + F+ L+K++TL LR N + I + +L +L +++L Sbjct: 83 DVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLE----------ELQSLRELDLYD 132 Query: 426 NLIHLSEN-----RLENLDILYFLLR-------VPHLQILILNQNRFSSCSGDQTPSENP 473 N I EN LE LDI + LLR + L+ L L N+ S + S Sbjct: 133 NQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI---ENLSNLH 189 Query: 474 SLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSL 533 L+ L LG N ++ + + L++L+ L+L N + L LT L LS+ Sbjct: 190 QLQMLELGSNRIR-------AIENIDTLTNLESLFLGKNKITKLQN--LDALTNLTVLSM 240 Query: 534 NSNRLTVLSHNDLPANLEILDISRNQL-LAPNPDVFVSLSVLDITHNKF 581 SNRLT + NL L +S N + + + L++LDI N+ Sbjct: 241 QSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRI 289 Score = 32.3 bits (72), Expect = 1.0, Method: Compositional matrix adjust. Identities = 44/148 (29%), Positives = 64/148 (43%), Gaps = 24/148 (16%) Query: 30 IAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKE 89 I+F N+ V + L ++L L N I + + L QLQ+LELGS E Sbjct: 152 ISFNLLRNIEGVDK-LTRLKKLFLVNNKISKI--ENLSNLHQLQMLELGSNRIRAI---E 205 Query: 90 AFRNLPNLRILDLGSSKIYFLHP-DAF----------------QGLFHLFELRLYFCGLS 132 L NL L LG +KI L DA +GL +L LR + + Sbjct: 206 NIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHN 265 Query: 133 DAVLKDGYFRNLKALTRLDLSKNQIRSL 160 + +G N K LT LD++ N+I+ + Sbjct: 266 GIEVIEGLENNNK-LTMLDIASNRIKKI 292 >4W8H-A nrPDB Length = 129 Score = 40.0 bits (92), Expect = 0.004, Method: Composition-based stats. Identities = 24/76 (31%), Positives = 39/76 (51%), Gaps = 5/76 (6%) Query: 693 YDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSR 752 YD +C++ +D WV N L+ L+ + + N+ RD PG NI DAI NS Sbjct: 5 YDVNICYAPEDREWVINTLVFKLE-RAGIKTFVNI----RDDTPGNFFAENIMDAIENSN 59 Query: 753 KIVCLVSRHFLRDGWC 768 + + ++S F ++ C Sbjct: 60 RTIVVMSPDFFKNNIC 75 >6HLU-A nrPDB Length = 974 Score = 39.3 bits (90), Expect = 0.007, Method: Compositional matrix adjust. Identities = 71/264 (26%), Positives = 123/264 (46%), Gaps = 34/264 (12%) Query: 310 TLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQK 369 +L L +L L NKI+ IA L +L L LS N + ++ + L + + L Sbjct: 133 SLNSLSMLWLFGNKISDIA--PLESLKSLTELQLSSNQITDI--APLASLKSLTELSLSG 188 Query: 370 NHIAIIQDQTFKFLEKLQTLDLRDNALTTIH---FIPSIPDIFLSGNKLVTLPKINLTAN 426 N+I+ I + L+ L L L N +T I + S+ ++ LS N++ + + + Sbjct: 189 NNISDIA--PLESLKSLTELSLSSNQITDIAPLASLKSLTELSLSSNQISDIAPLESLKS 246 Query: 427 L--IHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTP-SENPSLEQLFLGEN 483 L + LS N++ ++ L L + LQ L+ N+ + D P + SL +L L N Sbjct: 247 LTELQLSRNQISDIAPLESLKSLTELQ---LSSNQIT----DIAPLASLKSLTELQLSRN 299 Query: 484 MLQLAWETELCWDV--FEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVL 541 + D+ E L+ L L+LN N + + P + L +L L L+SN++T + Sbjct: 300 QIS---------DIAPLESLNSLSKLWLNGNQITDIAP--LASLNSLTELELSSNQITDI 348 Query: 542 SHNDLPANLEILDISRNQL--LAP 563 + +L L +S NQ+ +AP Sbjct: 349 APLASLKSLSTLWLSSNQISDIAP 372 Score = 34.7 bits (78), Expect = 0.20, Method: Compositional matrix adjust. Identities = 39/123 (31%), Positives = 60/123 (48%), Gaps = 15/123 (12%) Query: 87 DKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKA 146 D +L +L L L S++I + P A L L EL+L +SD +L + Sbjct: 259 DIAPLESLKSLTELQLSSNQITDIAPLA--SLKSLTELQLSRNQISDI----APLESLNS 312 Query: 147 LTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQG-KTLSFFSLAA 205 L++L L+ NQI + LNSL ++ SSNQI ++ PL K+LS L++ Sbjct: 313 LSKLWLNGNQITDIA---PLASLNSLTELELSSNQI-----TDIAPLASLKSLSTLWLSS 364 Query: 206 NSL 208 N + Sbjct: 365 NQI 367 Score = 33.5 bits (75), Expect = 0.41, Method: Compositional matrix adjust. Identities = 72/279 (25%), Positives = 126/279 (45%), Gaps = 29/279 (10%) Query: 310 TLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQK 369 +L L +L L N+I IA L++L +L L N + ++ + L + + L Sbjct: 111 SLNSLSMLWLDRNQITDIA--PLASLNSLSMLWLFGNKISDI--APLESLKSLTELQLSS 166 Query: 370 NHIAIIQDQTFKFLEKLQTLDLRDNALTTI---HFIPSIPDIFLSGNKLVTLPKINLTAN 426 N I I L+ L L L N ++ I + S+ ++ LS N++ + + + Sbjct: 167 NQITDIA--PLASLKSLTELSLSGNNISDIAPLESLKSLTELSLSSNQITDIAPLASLKS 224 Query: 427 L--IHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSEN-PSLEQLFLGEN 483 L + LS N++ ++ L L + LQ L++N+ S D P E+ SL +L L N Sbjct: 225 LTELSLSSNQISDIAPLESLKSLTELQ---LSRNQIS----DIAPLESLKSLTELQLSSN 277 Query: 484 MLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSH 543 + T++ L L L L+ N ++ + P L +L L LN N++T ++ Sbjct: 278 QI-----TDIA--PLASLKSLTELQLSRNQISDIAP--LESLNSLSKLWLNGNQITDIAP 328 Query: 544 NDLPANLEILDISRNQLLAPNP-DVFVSLSVLDITHNKF 581 +L L++S NQ+ P SLS L ++ N+ Sbjct: 329 LASLNSLTELELSSNQITDIAPLASLKSLSTLWLSSNQI 367 >4DOM-A nrPDB Length = 141 Score = 39.3 bits (90), Expect = 0.007, Method: Composition-based stats. Identities = 22/78 (28%), Positives = 39/78 (50%), Gaps = 5/78 (6%) Query: 692 KYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNS 751 ++DA++C+ D +VQ + + T Y R LC +RD +PG + + I Sbjct: 5 RFDAFICYCPSDIQFVQEMIRQLEQTNY----RLKLCVSDRDVLPGTCVWSIASELIEKR 60 Query: 752 -RKIVCLVSRHFLRDGWC 768 R++V +VS +L+ C Sbjct: 61 CRRMVVVVSDDYLQSKEC 78 >6O00-A nrPDB Length = 820 Score = 39.3 bits (90), Expect = 0.008, Method: Compositional matrix adjust. Identities = 67/242 (27%), Positives = 108/242 (44%), Gaps = 26/242 (10%) Query: 311 LKDLKVLNLAYN--KINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQ 368 LK LKVL L N K+ ++ + L L + N L+ ++ + + ++L Sbjct: 543 LKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLI---VLNSLKKMVNLTELELI 599 Query: 369 KNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIF------LSGNKLVTLP-KI 421 + + I F L LQ +DL+DN L TI I S + L N + +P +I Sbjct: 600 RCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQI 658 Query: 422 NLTANL--IHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLF 479 NL ++L+ N++E + F R L+ L L+ N + D +N L+ L Sbjct: 659 GNLTNLERLYLNRNKIEKIPTQLFYCR--KLRYLDLSHNNLTFLPADIGLLQN--LQNLA 714 Query: 480 LGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLT 539 + N ++ L ++F+ L+ L+L +N L SLP V LT L + L NRL Sbjct: 715 VTANRIE-----ALPPELFQ-CRKLRALHLGNNVLQSLPSRV-GELTNLTQIELRGNRLE 767 Query: 540 VL 541 L Sbjct: 768 CL 769 >4PUF-A nrPDB Length = 637 Score = 39.3 bits (90), Expect = 0.008, Method: Compositional matrix adjust. Identities = 56/203 (27%), Positives = 97/203 (47%), Gaps = 27/203 (13%) Query: 384 EKLQTLDLRDNALTTI--HFIPSIPDIFLSGNKLVTLPK-INLTANLIHLSENRLENLDI 440 E++ TL L +N L ++ + +I ++ + N+L ++P + T + LS NR+ L Sbjct: 71 EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELP- 129 Query: 441 LYFLLRVPH-LQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFE 499 R+P LQ L L N+ S C + P E L L + +N ++ L + Sbjct: 130 ----ERLPSALQSLDLFHNKIS-CLPENLPEE---LRYLSVYDNSIRT-----LPAHLPS 176 Query: 500 GLSHLQVLYLNHNYL-NSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRN 558 ++HL V + L +LPPG L+ L N LT L + LP L++LD+S+N Sbjct: 177 EITHLNVQSNSLTALPETLPPG-------LKTLEAGENALTSLPAS-LPPELQVLDVSKN 228 Query: 559 QLLAPNPDVFVSLSVLDITHNKF 581 Q+ + +++ LD++ N Sbjct: 229 QITVLPETLPPTITTLDVSRNAL 251 >4FZ5-A nrPDB Length = 154 Score = 37.7 bits (86), Expect = 0.023, Method: Composition-based stats. Identities = 26/89 (29%), Positives = 44/89 (49%), Gaps = 8/89 (8%) Query: 693 YDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSR 752 YD +C S +D Q+ L+ +L+ + F + RD PG ++ + A+ +S Sbjct: 19 YDVCVCHSEEDLVAAQD-LVSYLEGSTASLRCF---LQLRDATPGGAIVSELCQALSSSH 74 Query: 753 KIVCLVSRHFLRDGWC----LEAFSYAQG 777 V L++ FL+D WC L+A + A G Sbjct: 75 CRVLLITPGFLQDPWCKYQMLQALTEAPG 103 >4AY9-X nrPDB Length = 350 Score = 37.7 bits (86), Expect = 0.024, Method: Compositional matrix adjust. Identities = 59/235 (25%), Positives = 98/235 (41%), Gaps = 28/235 (11%) Query: 305 SRVFETLKDLK----VLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSN-FYGL 359 S+V E DL L K+ I AF G +L+ + +S N + E+ ++ F L Sbjct: 19 SKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNL 78 Query: 360 PKVAYIDLQK-NHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTL 418 PK+ I ++K N++ I + F+ L LQ L + + I +PD+ + L Sbjct: 79 PKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTG------IKHLPDVHKIHSLQKVL 132 Query: 419 PKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQ-TPSENPSLEQ 477 I N+ + N L +L + I ++ + F+ D+ S+N +LE Sbjct: 133 LDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNSAFNGTQLDELNLSDNNNLE- 191 Query: 478 LFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLS 532 EL DVF G S +L ++ ++SLP +L LR S Sbjct: 192 --------------ELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARS 232 Score = 34.3 bits (77), Expect = 0.21, Method: Compositional matrix adjust. Identities = 26/111 (23%), Positives = 51/111 (45%), Gaps = 4/111 (3%) Query: 24 CSFDGRIAFYRFCNLTQVPQVL--NTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQY 81 C R+ + +T++P L N E L +R + +F L+ +E+ Sbjct: 7 CHCSNRVFLCQESKVTEIPSDLPRNAIE-LRFVLTKLRVIQKGAFSGFGDLEKIEISQND 65 Query: 82 TPLTIDKEAFRNLPNLRILDL-GSSKIYFLHPDAFQGLFHLFELRLYFCGL 131 I+ + F NLP L + + ++ + +++P+AFQ L +L L + G+ Sbjct: 66 VLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGI 116 Score = 31.2 bits (69), Expect = 1.9, Method: Compositional matrix adjust. Identities = 22/69 (31%), Positives = 37/69 (53%), Gaps = 2/69 (2%) Query: 49 ERLLLSFN-YIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKI 107 E++ +S N + + A F L +L + + L I+ EAF+NLPNL+ L + ++ I Sbjct: 57 EKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGI 116 Query: 108 YFLHPDAFQ 116 L PD + Sbjct: 117 KHL-PDVHK 124 >5UZB-A nrPDB Length = 177 Score = 37.4 bits (85), Expect = 0.025, Method: Composition-based stats. Identities = 26/89 (29%), Positives = 44/89 (49%), Gaps = 8/89 (8%) Query: 693 YDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSR 752 YD +C S +D Q+ L+ +L+ + F + RD PG ++ + A+ +S Sbjct: 42 YDVCVCHSEEDLVAAQD-LVSYLEGSTASLRCF---LQLRDATPGGAIVSELCQALSSSH 97 Query: 753 KIVCLVSRHFLRDGWC----LEAFSYAQG 777 V L++ FL+D WC L+A + A G Sbjct: 98 CRVLLITPGFLQDPWCKYQMLQALTEAPG 126 >1XWD-C nrPDB Length = 252 Score = 36.6 bits (83), Expect = 0.043, Method: Compositional matrix adjust. Identities = 63/238 (26%), Positives = 108/238 (45%), Gaps = 34/238 (14%) Query: 305 SRVFETLKDLK----VLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSN-FYGL 359 S+V E DL L K+ I AF G +L+ + +S N + E+ ++ F L Sbjct: 19 SKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNL 78 Query: 360 PKVAYIDLQK-NHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTL 418 PK+ I ++K N++ I + F+ L LQ L + + I +PD+ +K+ +L Sbjct: 79 PKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTG------IKHLPDV----HKIHSL 128 Query: 419 PKINLTANLIHLSEN-RLENLDILYFLLRVPHLQILILNQN---RFSSCSGDQTPSENPS 474 K+ L+ + +N + ++ F+ IL LN+N +C+ + T Sbjct: 129 QKV-----LLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGT-----Q 178 Query: 475 LEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLS 532 L++L L +N EL DVF G S +L ++ ++SLP +L LR S Sbjct: 179 LDELNLSDN----NNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARS 232 Score = 34.7 bits (78), Expect = 0.17, Method: Compositional matrix adjust. Identities = 26/111 (23%), Positives = 51/111 (45%), Gaps = 4/111 (3%) Query: 24 CSFDGRIAFYRFCNLTQVPQVL--NTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQY 81 C R+ + +T++P L N E L +R + +F L+ +E+ Sbjct: 7 CHCSNRVFLCQESKVTEIPSDLPRNAIE-LRFVLTKLRVIQKGAFSGFGDLEKIEISQND 65 Query: 82 TPLTIDKEAFRNLPNLRILDL-GSSKIYFLHPDAFQGLFHLFELRLYFCGL 131 I+ + F NLP L + + ++ + +++P+AFQ L +L L + G+ Sbjct: 66 VLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGI 116 Score = 31.6 bits (70), Expect = 1.7, Method: Compositional matrix adjust. Identities = 22/69 (31%), Positives = 37/69 (53%), Gaps = 2/69 (2%) Query: 49 ERLLLSFN-YIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKI 107 E++ +S N + + A F L +L + + L I+ EAF+NLPNL+ L + ++ I Sbjct: 57 EKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGI 116 Query: 108 YFLHPDAFQ 116 L PD + Sbjct: 117 KHL-PDVHK 124 >1M9S-A nrPDB Length = 605 Score = 35.8 bits (81), Expect = 0.077, Method: Compositional matrix adjust. Identities = 47/159 (29%), Positives = 79/159 (49%), Gaps = 17/159 (10%) Query: 399 IHFIPSIPDIFLSGNKLVTLPKINLTANL--IHLSENRLENLDILYFLLRVPHLQILILN 456 I ++P++ +FL+GNKL + + NL + L EN++++L L L L+ L L Sbjct: 61 IQYLPNVTKLFLNGNKLTDIKPLTNLKNLGWLFLDENKIKDLSSLKDLK---KLKSLSLE 117 Query: 457 QNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNS 516 N S +G P LE L+LG N + T++ V L+ L L L N ++ Sbjct: 118 HNGISDING---LVHLPQLESLYLGNNKI-----TDIT--VLSRLTKLDTLSLEDNQISD 167 Query: 517 LPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDI 555 + P + LT L+ L L+ N ++ L NL++L++ Sbjct: 168 IVP--LAGLTKLQNLYLSKNHISDLRALAGLKNLDVLEL 204 >1JL5-A nrPDB Length = 454 Score = 35.4 bits (80), Expect = 0.12, Method: Compositional matrix adjust. Identities = 62/247 (25%), Positives = 103/247 (41%), Gaps = 42/247 (17%) Query: 394 NALTTIHFIP-SIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQI 452 N+LT + +P S+ + + N L L + + +S N+LE L L L+I Sbjct: 101 NSLTELPELPQSLKSLLVDNNNLKALSDLPPLLEYLGVSNNQLEKLPELQ---NSSFLKI 157 Query: 453 LILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHN 512 + ++ N + P PSLE + G N L+ E + L L +Y ++N Sbjct: 158 IDVDNNSLK-----KLPDLPPSLEFIAAGNNQLEELPE-------LQNLPFLTAIYADNN 205 Query: 513 YLNSLPP------------GVFSHLTALRGLSL------NSNRLTVLSHNDLPANLEILD 554 L LP + L L+ L ++N L L DLP +LE L+ Sbjct: 206 SLKKLPDLPLSLESIVAGNNILEELPELQNLPFLTTIYADNNLLKTLP--DLPPSLEALN 263 Query: 555 ISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPD 614 + R+ L P++ SL+ LD++ N F EL + +LN ++ I C P Sbjct: 264 V-RDNYLTDLPELPQSLTFLDVSENIFSGLSELPPNLYYLNASSNEIRS-----LCDLPP 317 Query: 615 SFSGVSL 621 S +++ Sbjct: 318 SLEELNV 324 Score = 29.6 bits (65), Expect = 6.4, Method: Compositional matrix adjust. Identities = 73/267 (27%), Positives = 117/267 (43%), Gaps = 32/267 (11%) Query: 297 HGFVFSLNS--RVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSS 354 V S NS + E + LK L + N + ++D L+ L V N L EL +S Sbjct: 94 ESLVASCNSLTELPELPQSLKSLLVDNNNLKALSDLPPL-LEYLGVSNNQLEKLPELQNS 152 Query: 355 NFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNK 414 +F + ID+ N + + D LE + + + L + +P + I+ N Sbjct: 153 SFLKI-----IDVDNNSLKKLPDLP-PSLEFIAAGNNQLEELPELQNLPFLTAIYADNNS 206 Query: 415 LVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPS 474 L LP + L+ I N LE L L L P L + + N + P PS Sbjct: 207 LKKLPDLPLSLESIVAGNNILEELPELQNL---PFLTTIYADNNLLKTL-----PDLPPS 258 Query: 475 LEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLN 534 LE L + +N L T+L ++ + L+ L V + L+ LPP ++ L+ + Sbjct: 259 LEALNVRDNYL-----TDLP-ELPQSLTFLDVSENIFSGLSELPPNLY-------YLNAS 305 Query: 535 SNRLTVLSHNDLPANLEILDISRNQLL 561 SN + L DLP +LE L++S N+L+ Sbjct: 306 SNEIRSLC--DLPPSLEELNVSNNKLI 330 >5YXM-A nrPDB Length = 203 Score = 34.7 bits (78), Expect = 0.18, Method: Composition-based stats. Identities = 44/155 (28%), Positives = 75/155 (48%), Gaps = 28/155 (18%) Query: 308 FETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDL 367 TLK K L L+ N I KI+ + G++NL++L+L NL+ ++ + L VA L Sbjct: 49 LSTLKACKHLALSTNNIEKIS--SLSGMENLRILSLGRNLIKKIEN-----LDAVADT-L 100 Query: 368 QKNHIAIIQDQTFKFLEK---LQTLDLRDNALTT------IHFIPSIPDIFLSGNKLVTL 418 ++ I+ Q + +EK L+ L + +N +T + + + D+ L+GN L Sbjct: 101 EELWISYNQIASLSGIEKLVNLRVLYMSNNKITNWGEIDKLAALDKLEDLLLAGNPLYND 160 Query: 419 PKINLTANLIHLSENRLENLDILYFLLRVPHLQIL 453 K N SE R+E + R+P+L+ L Sbjct: 161 YKENNAT-----SEYRIE------VVKRLPNLKKL 184 >5KH1-A nrPDB Length = 591 Score = 32.0 bits (71), Expect = 1.0, Method: Compositional matrix adjust. Identities = 34/135 (25%), Positives = 64/135 (47%), Gaps = 21/135 (15%) Query: 514 LNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSV 573 L +PPG+ + ++++ N L+++S LPA+L L++S N+L+ P + L + Sbjct: 82 LPEIPPGI-------KSINISKNNLSLIS--PLPASLTQLNVSYNRLIEL-PALPQGLKL 131 Query: 574 LDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEE 633 L+ +HN+ I L + L+ +N + P V P+ + + C+ Sbjct: 132 LNASHNQLITLPTLPISLKELHVSNNQLCSLP-----VLPELLETLDV------SCNGLA 180 Query: 634 VLKSLKFSLFIVCTV 648 VL L FSL + + Sbjct: 181 VLPPLPFSLQEISAI 195 Score = 31.6 bits (70), Expect = 1.5, Method: Compositional matrix adjust. Identities = 24/89 (26%), Positives = 47/89 (52%), Gaps = 5/89 (5%) Query: 360 PKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIP-SIPDIFLSGNKLVTL 418 P + I++ KN++++I L L++ N L + +P + + S N+L+TL Sbjct: 87 PGIKSINISKNNLSLIS----PLPASLTQLNVSYNRLIELPALPQGLKLLNASHNQLITL 142 Query: 419 PKINLTANLIHLSENRLENLDILYFLLRV 447 P + ++ +H+S N+L +L +L LL Sbjct: 143 PTLPISLKELHVSNNQLCSLPVLPELLET 171 >2M1W-A nrPDB Length = 166 Score = 31.6 bits (70), Expect = 1.4, Method: Compositional matrix adjust. Identities = 12/32 (37%), Positives = 19/32 (59%) Query: 737 GENRIANIQDAIWNSRKIVCLVSRHFLRDGWC 768 G + N+ DA+ S + L++ +FLRD WC Sbjct: 49 GRQHLQNLDDAVNGSAWTILLLTENFLRDTWC 80 >3G06-A nrPDB Length = 622 Score = 31.2 bits (69), Expect = 2.2, Method: Compositional matrix adjust. Identities = 17/50 (34%), Positives = 32/50 (64%), Gaps = 1/50 (2%) Query: 393 DNALTTIHFIPS-IPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDIL 441 +N LT++ +PS + ++ +SGN+L +LP + + +S NRL +L +L Sbjct: 210 NNRLTSLPALPSGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPML 259 Score = 30.0 bits (66), Expect = 4.3, Method: Compositional matrix adjust. Identities = 60/217 (27%), Positives = 100/217 (46%), Gaps = 32/217 (14%) Query: 360 PKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPS-IPDIFLSGNKLVTL 418 P++ +++ N + + LE L + N LT + +PS + +++ GN+L +L Sbjct: 81 PELRTLEVSGNQLTSLPVLPPGLLE----LSIFSNPLTHLPALPSGLCKLWIFGNQLTSL 136 Query: 419 PKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQL 478 P + + +S+N+L +L L L L N+ +S P L++L Sbjct: 137 PVLPPGLQELSVSDNQLASLPALPS-----ELCKLWAYNNQLTSL-----PMLPSGLQEL 186 Query: 479 FLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRL 538 + +N QLA L S L L+ +N L SLP + + L+ L ++ NRL Sbjct: 187 SVSDN--QLASLPTLP-------SELYKLWAYNNRLTSLP----ALPSGLKELIVSGNRL 233 Query: 539 TVLSHNDLPANLEILDISRNQL--LAPNPDVFVSLSV 573 T L LP+ L+ L +S N+L L P +SLSV Sbjct: 234 TSLPV--LPSELKELMVSGNRLTSLPMLPSGLLSLSV 268 Score = 28.9 bits (63), Expect = 9.8, Method: Compositional matrix adjust. Identities = 21/70 (30%), Positives = 35/70 (50%), Gaps = 16/70 (22%) Query: 386 LQTLDLRDNALTTIHFIPS-IPDIFLSGNKLVTLPKI---------------NLTANLIH 429 L+ L + N LT++ +PS + ++ +SGN+L +LP + L +LIH Sbjct: 223 LKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIH 282 Query: 430 LSENRLENLD 439 LS NL+ Sbjct: 283 LSSETTVNLE 292 >3G04-C nrPDB Length = 239 Score = 30.8 bits (68), Expect = 2.4, Method: Compositional matrix adjust. Identities = 24/112 (21%), Positives = 55/112 (49%), Gaps = 2/112 (1%) Query: 22 PSCSFDGRIAFYRFC-NLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQ 80 P C F C ++ ++P + +T+ L L ++RT+ + +F L + + + Sbjct: 6 PPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSID 65 Query: 81 YTPLTIDKEAFRNLPNLRILDLGSSK-IYFLHPDAFQGLFHLFELRLYFCGL 131 T ++ +F NL + +++ +++ + ++ PDA + L L L ++ GL Sbjct: 66 VTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGL 117 >3A79-B nrPDB Length = 562 Score = 30.0 bits (66), Expect = 4.6, Method: Compositional matrix adjust. Identities = 25/81 (30%), Positives = 46/81 (56%), Gaps = 4/81 (4%) Query: 288 SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNL 347 S +R L LSH + SL+ VF +DL+ L++++N++ I + + +L+ L+LS+N Sbjct: 76 SELRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHNRLQNI---SCCPMASLRHLDLSFND 132 Query: 348 LGELYSSNFYG-LPKVAYIDL 367 L +G L K+ ++ L Sbjct: 133 FDVLPVCKEFGNLTKLTFLGL 153 >4MSX-A nrPDB Length = 482 Score = 30.0 bits (66), Expect = 4.8, Method: Compositional matrix adjust. Identities = 22/67 (32%), Positives = 35/67 (52%), Gaps = 2/67 (2%) Query: 409 FLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQT 468 F GN + LP+IN+T L +++R + ++ L R+P Q LI + NRF S Sbjct: 333 FEDGNSVDDLPQINITKLLTKFTKSRSSSTSTVFELTRLP--QFLIFHFNRFDRNSDHPV 390 Query: 469 PSENPSL 475 + N +L Sbjct: 391 KNRNQTL 397 >1XKT-A nrPDB Length = 289 Score = 29.6 bits (65), Expect = 5.6, Method: Compositional matrix adjust. Identities = 21/58 (36%), Positives = 30/58 (51%), Gaps = 10/58 (17%) Query: 157 IRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSV 214 +RSL ++P L L S+ S +FLV P++G T F SLA SR+S+ Sbjct: 6 LRSLLVNPEGPTLMRLNSVQSSERPLFLV-----HPIEGSTTVFHSLA-----SRLSI 53 >5XXB-C nrPDB Length = 416 Score = 29.6 bits (65), Expect = 6.0, Method: Compositional matrix adjust. Identities = 23/75 (30%), Positives = 33/75 (44%), Gaps = 9/75 (12%) Query: 89 EAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLF------ELRLYF---CGLSDAVLKDG 139 AFRN+P + + + S + L P G F L+ L+L F G A LK G Sbjct: 220 RAFRNIPGVELCKVDSLNLLQLAPGGALGRFCLYTASAFKRLQLLFGRHTGTGTAQLKKG 279 Query: 140 YFRNLKALTRLDLSK 154 Y ++ DLS+ Sbjct: 280 YHLPRALMSNADLSR 294 >4PBW-B nrPDB Length = 283 Score = 29.3 bits (64), Expect = 8.3, Method: Compositional matrix adjust. Identities = 26/81 (32%), Positives = 37/81 (45%), Gaps = 14/81 (17%) Query: 59 RTVTASSFPFLEQLQLL-----ELGSQYTPLTIDKEAFRNL--------PNLRILDLGSS 105 R +T+ + LQ L EL + LTI RN+ P+LR +DL + Sbjct: 50 RNITSIHIENWKNLQTLNAVDMELYTGLQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGN 109 Query: 106 KIYFLHPDAFQGLFHLFELRL 126 ++ L FQ L LF+LRL Sbjct: 110 RLTTLSWQLFQTL-RLFDLRL 129 >5TEB-A nrPDB Length = 168 Score = 29.3 bits (64), Expect = 8.6, Method: Composition-based stats. Identities = 25/111 (22%), Positives = 48/111 (43%), Gaps = 16/111 (14%) Query: 744 IQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMKH 803 +++AI S+ + L+SR + WCL+ A+ ++ ++M + + + K Sbjct: 51 LKEAIKGSKIAIVLLSRKYASSSWCLDEL--AEIMICREVLGQIVMTIFYEVDPTDIKKQ 108 Query: 804 ---------QSIRGFVQKQQYLRWPEDFQDV----GWFLHKLSQQILKKEK 841 ++ RG K+Q RW + +DV G+ HK + EK Sbjct: 109 TGEFGKAFTKTCRG-KPKEQVERWRKALEDVATIAGYHSHKWCDEAEMIEK 158 >4PBV-A nrPDB Length = 268 Score = 28.9 bits (63), Expect = 9.3, Method: Compositional matrix adjust. Identities = 28/88 (31%), Positives = 39/88 (44%), Gaps = 14/88 (15%) Query: 52 LLSFNYIRTVTASSFPFLEQLQLL-----ELGSQYTPLTIDKEAFRNL--------PNLR 98 LL R +T+ + LQ L EL + LTI RN+ P+LR Sbjct: 28 LLEGQDSRNITSIHIENWKNLQTLNAVDMELYTGLQRLTIRNSGLRNIQPRAFAKNPHLR 87 Query: 99 ILDLGSSKIYFLHPDAFQGLFHLFELRL 126 +DL +++ L FQ L LF+LRL Sbjct: 88 YIDLSGNRLTTLSWQLFQTL-RLFDLRL 114 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3J0A-A nrPDB 969 0.0 5Y3K-A nrPDB 410 e-114 5ZSN-B nrPDB 405 e-113 5Y3M-A nrPDB 382 e-106 3T6Q-A nrPDB 362 e-100 3WPI-A nrPDB 361 1e-99 5GY2-A nrPDB 359 3e-99 3CIG-A nrPDB 347 1e-95 3B2D-A nrPDB 343 2e-94 4R08-A nrPDB 332 6e-91 3V44-A nrPDB 323 2e-88 3RG1-A nrPDB 320 2e-87 3ULU-A nrPDB 317 2e-86 6GFF-I nrPDB 265 8e-71 3A7C-A nrPDB 237 2e-62 1FYV-A nrPDB 223 4e-58 5D3I-A nrPDB 213 2e-55 2J67-A nrPDB 212 4e-55 4OM7-A nrPDB 210 2e-54 2Z7X-A nrPDB 208 7e-54 1O77-A nrPDB 200 2e-51 4QDH-A nrPDB 193 3e-49 5LFN-A nrPDB 187 2e-47 2Z80-A nrPDB 174 2e-43 2FT3-A nrPDB 159 5e-39 4R6F-A nrPDB 158 7e-39 1XCD-A nrPDB 139 6e-33 5YQ5-A nrPDB 134 2e-31 5MX0-A nrPDB 129 4e-30 2Z7X-B nrPDB 129 4e-30 2XOT-A nrPDB 126 6e-29 2JS7-A nrPDB 123 2e-28 5Y31-B nrPDB 118 1e-26 6HKW-A nrPDB 106 3e-23 5XJX-C nrPDB 101 1e-21 2V9T-B nrPDB 97 3e-20 Sequences not found previously or not previously below threshold: 6HLU-A nrPDB 122 4e-28 3A79-B nrPDB 122 8e-28 4DOM-A nrPDB 110 3e-24 6O00-A nrPDB 105 1e-22 3G06-A nrPDB 85 1e-16 1JL5-A nrPDB 82 8e-16 4ECN-A nrPDB 79 1e-14 4PUF-A nrPDB 78 1e-14 4AY9-X nrPDB 75 2e-13 4W8H-A nrPDB 71 2e-12 1XWD-C nrPDB 70 5e-12 3TSR-E nrPDB 66 5e-11 4PEQ-B nrPDB 66 7e-11 2BNH-A nrPDB 65 2e-10 1M9S-A nrPDB 64 2e-10 5YXM-A nrPDB 64 3e-10 3G04-C nrPDB 62 1e-09 1T3G-A nrPDB 60 5e-09 2Q4G-W nrPDB 59 6e-09 1OGQ-A nrPDB 57 4e-08 5KH1-A nrPDB 56 6e-08 3CVR-A nrPDB 55 1e-07 2IFG-A nrPDB 54 2e-07 6ICZ-o nrPDB 54 4e-07 6J5T-G nrPDB 52 1e-06 4K17-A nrPDB 52 1e-06 4PBW-B nrPDB 49 7e-06 5UZB-A nrPDB 49 7e-06 4FZ5-A nrPDB 49 7e-06 3JB9-j nrPDB 49 8e-06 4PBV-A nrPDB 49 1e-05 1DCE-A nrPDB 47 4e-05 5KU7-A nrPDB 42 0.001 4WYK-A nrPDB 42 0.001 1KOH-A nrPDB 41 0.002 2CA6-A nrPDB 41 0.002 3JRN-A nrPDB 41 0.003 6MDV-A nrPDB 38 0.019 4NUY-A nrPDB 37 0.026 5LJ5-W nrPDB 36 0.062 2M1W-A nrPDB 35 0.18 2P1O-B nrPDB 33 0.59 4ZL4-A nrPDB 33 0.72 4UF0-B nrPDB 32 0.88 6FE8-D nrPDB 32 1.1 5N23-A nrPDB 32 1.2 4LZP-B nrPDB 32 1.3 5YTI-A nrPDB 31 2.3 3H16-A nrPDB 30 4.2 1P9B-A nrPDB 30 4.5 6MZB-A nrPDB 30 5.5 3OL6-A nrPDB 29 6.4 2IJD-1 nrPDB 29 6.4 1RAJ-A nrPDB 29 7.0 5WLC-LS nrPDB 29 7.7 >3J0A-A nrPDB Length = 844 Score = 969 bits (2504), Expect = 0.0, Method: Composition-based stats. Identities = 836/836 (100%), Positives = 836/836 (100%) Query: 23 SCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYT 82 SCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYT Sbjct: 1 SCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYT 60 Query: 83 PLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFR 142 PLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFR Sbjct: 61 PLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFR 120 Query: 143 NLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFS 202 NLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFS Sbjct: 121 NLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFS 180 Query: 203 LAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAH 262 LAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAH Sbjct: 181 LAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAH 240 Query: 263 HIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN 322 HIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN Sbjct: 241 HIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN 300 Query: 323 KINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKF 382 KINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKF Sbjct: 301 KINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKF 360 Query: 383 LEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILY 442 LEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILY Sbjct: 361 LEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILY 420 Query: 443 FLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLS 502 FLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLS Sbjct: 421 FLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLS 480 Query: 503 HLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLA 562 HLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLA Sbjct: 481 HLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLA 540 Query: 563 PNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLF 622 PNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLF Sbjct: 541 PNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLF 600 Query: 623 SLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFKDH 682 SLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFKDH Sbjct: 601 SLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFKDH 660 Query: 683 PQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIA 742 PQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIA Sbjct: 661 PQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIA 720 Query: 743 NIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMK 802 NIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMK Sbjct: 721 NIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMK 780 Query: 803 HQSIRGFVQKQQYLRWPEDFQDVGWFLHKLSQQILKKEKEKKKDNNIPLQTVATIS 858 HQSIRGFVQKQQYLRWPEDFQDVGWFLHKLSQQILKKEKEKKKDNNIPLQTVATIS Sbjct: 781 HQSIRGFVQKQQYLRWPEDFQDVGWFLHKLSQQILKKEKEKKKDNNIPLQTVATIS 836 >5Y3K-A nrPDB Length = 802 Score = 410 bits (1053), Expect = e-114, Method: Composition-based stats. Identities = 172/658 (26%), Positives = 271/658 (41%), Gaps = 89/658 (13%) Query: 34 RFCNLTQVPQVLNTT-ERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPL-------- 84 ++ NLT VP+ L + E LLLS+N+I T+ L L++L++G Sbjct: 186 KYNNLTTVPRSLPPSLEYLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCV 245 Query: 85 -------TIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLK 137 + + F +L L L L S +Y L+P F+GL +L L L L D + K Sbjct: 246 ECPHKFPQLHSDTFSHLSRLEGLVLKDSSLYQLNPRWFRGLGNLTVLDLSENFLYDCITK 305 Query: 138 DGYFRNLKALTRLDLSKNQIRS-----LYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEP 192 F+ L L RL+LS N + L L PSFG L SL+ +D + + L+P Sbjct: 306 TKAFQGLAQLRRLNLSFNYHKKVSFAHLTLAPSFGSLLSLQELDMHGIFFRSLSQKTLQP 365 Query: 193 LQG-KTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNA-- 249 L L L N ++ + K R + L +SG V TG Sbjct: 366 LARLPMLQRLYLQMN-FINQAQLGIFKDFPGLRYIDLSDNRISGAVEPVATTGEVDGGKK 424 Query: 250 --------------ISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDL 295 S+ F + +N+ FA L+R ++ L L Sbjct: 425 VWLTSRDLTPGPLDTPSSEDFMPSCKNLSFTLDLSRNNLVTVQPEMFAQLSR--LQCLRL 482 Query: 296 SHGFVF-SLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYN-----LLG 349 SH + ++N F L L+VL+L++NK++ +F L L+ L+LSYN + G Sbjct: 483 SHNSISQAVNGSQFVPLTSLQVLDLSHNKLDLYHGRSFTELPRLEALDLSYNSQPFSMRG 542 Query: 350 ELYSSNFYG-LPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDI 408 ++ +F LP + Y+ L N I Q L LD N+L+ + + Sbjct: 543 VGHNLSFVAQLPTLRYLSLAHNGIHSRVSQQLCS-TSLWALDFSGNSLSQMWAEGDLYLR 601 Query: 409 FLSGNKLVTLPKINLTANLIH-LSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQ 467 F G L +L +++L+ N +H L L NL LLR+ + + N + + Sbjct: 602 FFQG--LRSLIRLDLSQNRLHTLLPCTLGNLPKSLQLLRLRNNYLAFFNWSSLT------ 653 Query: 468 TPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTA 527 P+LE L L N L+ L + LQ L ++ N + + PG F+ T Sbjct: 654 ---LLPNLETLDLAGNQLKALSNGSLPSG-----TQLQRLDVSRNSIIFVVPGFFALATR 705 Query: 528 LRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECEL 587 LR L+L++N L + P+ L SL VLD++ N C C Sbjct: 706 LRELNLSANALRTVE----PSWFGFLA--------------GSLEVLDVSANPLHCACG- 746 Query: 588 STFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIV 645 + F+++L + G P+ + C P G S+F+ C +E SL + F+V Sbjct: 747 AAFVDFLLQVQAAVPGLPSRVKCGSPGQLQGRSIFAQDLRLCLDE----SLSWDEFLV 800 Score = 101 bits (250), Expect = 2e-21, Method: Composition-based stats. Identities = 71/329 (21%), Positives = 116/329 (35%), Gaps = 52/329 (15%) Query: 286 ARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN---------KIN---KIADEAFY 333 R +V L L + L+ F L +L+ LNL +N I F Sbjct: 40 PRDNVTSLSLLSNRIHHLHDSDFAQLSNLQKLNLKWNCPPAGLSPMHFPCHMTIEPNTFL 99 Query: 334 GLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRD 393 + L+ LNLSYN + + + + + L + +I + + L L+ L + Sbjct: 100 AVPTLEELNLSYNGITTVPALP----SSLVSLILSRTNILQLDPTSLTGLHALRFLYMDG 155 Query: 394 NALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQIL 453 N ++ + L L ++L N + L P L+ L Sbjct: 156 NCYYKNPCGRALEVAPGALLGLGNLTHLSLKYNNLTTVPRSLP-----------PSLEYL 204 Query: 454 ILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWET-----------ELCWDVFEGLS 502 +L+ N + + + + +L L +G N + +L D F LS Sbjct: 205 LLSYNHIVTLAPEDL-ANLTALRVLDVGGNCRRCDHARNPCVECPHKFPQLHSDTFSHLS 263 Query: 503 HLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNR----LTVLSHNDLPANLEILDISRN 558 L+ L L + L L P F L L L L+ N +T A L L++S N Sbjct: 264 RLEGLVLKDSSLYQLNPRWFRGLGNLTVLDLSENFLYDCITKTKAFQGLAQLRRLNLSFN 323 Query: 559 ---------QLLAPNPDVFVSLSVLDITH 578 LAP+ +SL LD+ Sbjct: 324 YHKKVSFAHLTLAPSFGSLLSLQELDMHG 352 >5ZSN-B nrPDB Length = 823 Score = 405 bits (1041), Expect = e-113, Method: Composition-based stats. Identities = 162/644 (25%), Positives = 271/644 (42%), Gaps = 58/644 (9%) Query: 29 RIAFYRFCNLTQVPQVLNTT-ERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYT----- 82 ++ + N+T VP VL +T L L N I + F L QLQ+L+L Sbjct: 185 KVLSLKDNNVTTVPTVLPSTLTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCYNA 244 Query: 83 -----------PLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGL 131 PL I AF L L++L L S+ + + P F+ + +L EL L L Sbjct: 245 PFPCTPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFL 304 Query: 132 SDAVLKDGYFRNLKALTRLDLSKN-----QIRSLYLHPSFGKLNSLKSIDFSSNQIFLVC 186 + + + L L +LDLS N S+ L +F L SLK + + Sbjct: 305 AKEIGDAKFLHFLPNLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELK 364 Query: 187 EHELEPLQG-KTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGN 245 +L PL + L L N ++ K + + L + +S +G ++ G+ Sbjct: 365 SFQLSPLHNLQNLEVLDLGTN-FIKIANLSMFKQFKRLKVIDLSVNKISPSGDSLVPRGS 423 Query: 246 FSNAISKSQAFSLILAHHIM-------GAGFGFHNIKDPDQNTFAGLARSSVRH---LDL 295 SNA + +++ + + F N + +F + S ++ LDL Sbjct: 424 -SNARTSVESYEPQVLEQLYYFRYDKYARSCRFKN----KEASFTSVQESCYKYGQTLDL 478 Query: 296 SHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEA-FYGLDNLQVLNLSYNLLGELYSS 354 S +F + S F+ L LK LNL+ N I++ + + F L L+ L+ S N L L+S+ Sbjct: 479 SKNSIFFIKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHST 538 Query: 355 NFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNK 414 F L K+ +D+ N + L + L + + + I S + Sbjct: 539 AFEELRKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESES 598 Query: 415 LVTLP-KINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENP 473 L TL + N L +NR L + L+ L +++N S P Sbjct: 599 LRTLEFRGNHLDVLWRDGDNRYLQL-----FKNLLKLEELDISKNSLSFLPSGVFDGMPP 653 Query: 474 SLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSL 533 +L+ L L +N L+ W+ L +L+ L L+HN L ++P + + +L+ L L Sbjct: 654 NLKNLSLAKNGLK-----SFIWEKLRYLKNLETLDLSHNQLTTVPERLSNCSRSLKNLIL 708 Query: 534 NSNRLTVLSHNDLPA--NLEILDISRNQLLAPNP-----DVFVSLSVLDITHNKFICECE 586 +N++ L+ L L LD+S N++ +V +L +L + HN+F+C C+ Sbjct: 709 KNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCD 768 Query: 587 LSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCD 630 F+ W+ HT VTI D+ CV P + G S+ SL C+ Sbjct: 769 AVWFVWWVQHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCE 812 Score = 109 bits (272), Expect = 6e-24, Method: Composition-based stats. Identities = 112/626 (17%), Positives = 197/626 (31%), Gaps = 145/626 (23%) Query: 17 PVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSF-NYIRTVTASSFPFLEQLQLL 75 P S + I +LT++P + T L N+I ++ +SF L L + Sbjct: 13 PCDVTLDVSKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLVHLVEI 72 Query: 76 ELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAV 135 + P+ + ++ L + P +F GL +L Sbjct: 73 DFRCNCVPIRLGSKSNMCPRRL-----------QIKPRSFSGLTYLK------------- 108 Query: 136 LKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQG 195 L L NQ+ + +N IF + + +L L Sbjct: 109 -------------SLYLDGNQLLEIPQGLPPSLQLLSLE----ANNIFSIRKEQLTELAN 151 Query: 196 KTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQA 255 +EIL + N + + + A Sbjct: 152 --------------------------------IEILYLGQN--CYYRNPCYVSYSIEKDA 177 Query: 256 FSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLK 315 F + ++KD + T + S++ L L + + + F L L+ Sbjct: 178 F-------LNLTKLKVLSLKDNNVTTVPTVLPSTLTELYLYNNMIAEIQEDDFNNLNQLQ 230 Query: 316 VLNLA-----------------YNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYG 358 +L+L+ N +I AF L L+VL L N L + F Sbjct: 231 ILDLSGNCPRCYNAPFPCTPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKN 290 Query: 359 LPKVAYIDLQKNHIAI--IQDQTFKFLEKLQTLDL-----------RDNALTTIHFIPSI 405 + + +DL +N +A + FL L LDL N + S+ Sbjct: 291 INNLQELDLSQNFLAKEIGDAKFLHFLPNLIQLDLSFNFELQVYRASMNLSQAFSSLKSL 350 Query: 406 PDIFLSGNKLVTLPKINLTA-------NLIHLSENRLENLDILYFLLRVPHLQILILNQN 458 + + G L L+ ++ L N ++ ++ + L+++ L+ N Sbjct: 351 KILRIRGYVFKELKSFQLSPLHNLQNLEVLDLGTNFIKIANLS-MFKQFKRLKVIDLSVN 409 Query: 459 RFSSCSGDQTPSENPS------------LEQLFLGENMLQ------LAWETELCWDVFEG 500 + S P + + LEQL+ E Sbjct: 410 KISPSGDSLVPRGSSNARTSVESYEPQVLEQLYYFRYDKYARSCRFKNKEASFTSVQESC 469 Query: 501 LSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLT---VLSHNDLPANLEILDISR 557 + Q L L+ N + + F HL+ L+ L+L+ N ++ S A L LD S Sbjct: 470 YKYGQTLDLSKNSIFFIKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSN 529 Query: 558 NQLLAPNPDVFV---SLSVLDITHNK 580 N+L + F L VLDI+ N Sbjct: 530 NRLDLLHSTAFEELRKLEVLDISSNS 555 >5Y3M-A nrPDB Length = 801 Score = 382 bits (982), Expect = e-106, Method: Composition-based stats. Identities = 159/658 (24%), Positives = 258/658 (39%), Gaps = 90/658 (13%) Query: 34 RFCNLTQVPQVLNTT-ERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPL-------- 84 ++ NLT+VP+ L + + LLLS+N+I T+ L L++L++G Sbjct: 186 KYNNLTEVPRRLPPSLDTLLLSYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCR 245 Query: 85 -------TIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLK 137 + + F +L L L L S +Y L D F+GL L L L L D + K Sbjct: 246 ECPKNFPKLHPDTFSHLSRLEGLVLKDSSLYKLEKDWFRGLGRLQVLDLSENFLYDYITK 305 Query: 138 DGYFRNLKALTRLDLSKNQIRS-----LYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEP 192 F +L L RL+LS N + L+L SFG L SL+ +D + L+ Sbjct: 306 TTIFNDLTQLRRLNLSFNYHKKVSFAHLHLASSFGSLVSLEKLDMHGIFFRSLTNITLQS 365 Query: 193 LQG-KTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAIS 251 L L L N ++ + + L +SG G + + Sbjct: 366 LTRLPKLQSLHLQLN-FINQAQLSIFGAFPSLLFVDLSDNRISGAATPAAALGEVDSRVE 424 Query: 252 ----------------KSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDL 295 S+ F + +N+ Q F L+R ++ L L Sbjct: 425 VWRLPRGLAPGPLDAVSSKDFMPSC-NLNFTLDLSRNNLVTIQQEMFTRLSR--LQCLRL 481 Query: 296 SHGFVF-SLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYN-----LLG 349 SH + ++N F L L+VL+L++NK++ +F L L+ L+LSYN + G Sbjct: 482 SHNSISQAVNGSQFVPLTSLRVLDLSHNKLDLYHGRSFTELPQLEALDLSYNSQPFSMQG 541 Query: 350 ELYSSNFYG-LPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDI 408 ++ +F LP + Y+ L N I Q L+ LD N+L+ + + Sbjct: 542 VGHNLSFVAQLPSLRYLSLAHNGIHSRVSQKLSS-ASLRALDFSGNSLSQMWAEGDLYLC 600 Query: 409 FLSGNKLVTLPKINLTANLIH-LSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQ 467 F G L L +++L+ N +H L L+NL LR+ + N + + Sbjct: 601 FFKG--LRNLVQLDLSENHLHTLLPRHLDNLPKSLRQLRLRDNNLAFFNWSSLT------ 652 Query: 468 TPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTA 527 P LE L L N L+ L + LQ L ++ N + + PG F T Sbjct: 653 ---VLPRLEALDLAGNQLKALSNGSLPPGI-----RLQKLDVSSNSIGFVIPGFFVRATR 704 Query: 528 LRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECEL 587 L L+L++N L + P+ L +L +LD++ N C C Sbjct: 705 LIELNLSANALKTVD----PSWFGSLA--------------GTLKILDVSANPLHCACG- 745 Query: 588 STFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIV 645 + F+++L + G + C P G S+F+ C +E L F+V Sbjct: 746 AAFVDFLLERQEAVPGLSRRVTCGSPGQLQGRSIFTQDLRLCLDET----LSLDEFLV 799 Score = 97.5 bits (241), Expect = 2e-20, Method: Composition-based stats. Identities = 77/374 (20%), Positives = 129/374 (34%), Gaps = 79/374 (21%) Query: 283 AGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN---------KIN---KIADE 330 AG R++V L L + L+ F L +L+VLNL +N I Sbjct: 37 AGAPRANVTSLSLISNRIHHLHDSDFVHLSNLRVLNLKWNCPPAGLSPMHFPCRMTIEPN 96 Query: 331 AFYGLDNLQVLNLSYNLLGELY--------------------SSNFYGLPKVAYIDLQKN 370 F + L+ LNLSYN + + ++F GL + ++ + N Sbjct: 97 TFLAVPTLEELNLSYNGITTVPALPSSLVSLSLSHTSILVLGPTHFTGLHALRFLYMDGN 156 Query: 371 HIAI--------IQDQTFKFLEKLQTLDLRDNALTTIH--FIPSIPDIFLSGN------- 413 + + L L L L+ N LT + PS+ + LS N Sbjct: 157 CYYMNPCPRALEVAPGALLGLGNLTHLSLKYNNLTEVPRRLPPSLDTLLLSYNHIVTLAP 216 Query: 414 ----KLVTLPKINLTANLIHLSENR------LENLDILYF--LLRVPHLQILILNQNRFS 461 L L +++ N R +N L+ + L+ L+L + Sbjct: 217 EDLANLTALRVLDVGGNCRRCDHARNPCRECPKNFPKLHPDTFSHLSRLEGLVLKDSSLY 276 Query: 462 SCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLP--- 518 D L+ L L EN L +F L+ L+ L L+ NY + Sbjct: 277 KLEKDWF-RGLGRLQVLDLSENFLYDYITK---TTIFNDLTQLRRLNLSFNYHKKVSFAH 332 Query: 519 ---PGVFSHLTALRGLSLNSNRLTVLSHNDLPA-----NLEILDISRNQLLAPNPDV--- 567 F L +L L ++ L++ L + L+ L + N + + Sbjct: 333 LHLASSFGSLVSLEKLDMHGIFFRSLTNITLQSLTRLPKLQSLHLQLNFINQAQLSIFGA 392 Query: 568 FVSLSVLDITHNKF 581 F SL +D++ N+ Sbjct: 393 FPSLLFVDLSDNRI 406 >3T6Q-A nrPDB Length = 606 Score = 362 bits (929), Expect = e-100, Method: Composition-based stats. Identities = 141/608 (23%), Positives = 244/608 (40%), Gaps = 47/608 (7%) Query: 33 YRFCNLTQVPQVLN-TTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAF 91 L ++P L +TE L SFN + T+ ++F L L L+L ++ I ++ F Sbjct: 19 CENLGLNEIPGTLPNSTECLEFSFNVLPTIQNTTFSRLINLTFLDL-TRCQIYWIHEDTF 77 Query: 92 RNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLD 151 ++ L L L ++ + F+ A G L L G+S + N K L L Sbjct: 78 QSQHRLDTLVLTANPLIFMAETALSGPKALKHLFFIQTGISS--IDFIPLHNQKTLESLY 135 Query: 152 LSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSR 211 L N I S+ L F LK +DF +N I + + ++ LQ T +L N + Sbjct: 136 LGSNHISSIKLPKGFPTE-KLKVLDFQNNAIHYLSKEDMSSLQQATNLSLNLNGNDIA-- 192 Query: 212 VSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGF 271 G F + V + L+ G + I N+ +S F Sbjct: 193 -----GIEPGAFDSAVFQSLNFGGTQNLLVIFKGLKNSTIQSLWLG------------TF 235 Query: 272 HNIKDPDQN--TFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIAD 329 ++ D D + F GL SV ++L + F+++S F L+ L+L ++++ Sbjct: 236 EDMDDEDISPAVFEGLCEMSVESINLQKHYFFNISSNTFHCFSGLQELDLTATHLSELPS 295 Query: 330 EAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAI-IQDQTFKFLEKLQT 388 GL L+ L LS N L + P + ++ ++ N + + + LE L+ Sbjct: 296 G-LVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTKRLELGTGCLENLENLRE 354 Query: 389 LDLRDNALTT-------IHFIPSIPDIFLSGNKLVTLP----KINLTANLIHLSENRLEN 437 LDL + + T + + + + LS N+ ++L K L+ L+ RL+ Sbjct: 355 LDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKV 414 Query: 438 LDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDV 497 D + L++L L+ + S +Q P+L+ L L N + + Sbjct: 415 KDAQSPFQNLHLLKVLNLSHS-LLDISSEQLFDGLPALQHLNLQGNHFPKGNIQK--TNS 471 Query: 498 FEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEI-LDIS 556 + L L++L L+ L+S+ F+ L + + L+ NRLT S L I L+++ Sbjct: 472 LQTLGRLEILVLSFCDLSSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNLA 531 Query: 557 RNQLLAPNPDVFVSLS---VLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYP 613 N + P + LS +++ N C C F+ W N+ D C P Sbjct: 532 SNHISIILPSLLPILSQQRTINLRQNPLDCTCSNIYFLEWYKE-NMQKLEDTEDTLCENP 590 Query: 614 DSFSGVSL 621 GV L Sbjct: 591 PLLRGVRL 598 Score = 84.1 bits (206), Expect = 3e-16, Method: Composition-based stats. Identities = 79/422 (18%), Positives = 156/422 (36%), Gaps = 29/422 (6%) Query: 248 NAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRV 307 N I + S F F+ + TF+ L ++ LDL+ ++ ++ Sbjct: 25 NEIPGTLPNSTECLE------FSFNVLPTIQNTTFSRL--INLTFLDLTRCQIYWIHEDT 76 Query: 308 FETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDL 367 F++ L L L N + +A+ A G L+ L + + + + + L Sbjct: 77 FQSQHRLDTLVLTANPLIFMAETALSGPKALKHLFFIQTGISSIDFIPLHNQKTLESLYL 136 Query: 368 QKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFI-------PSIPDIFLSGNKLVTLPK 420 NHI+ I+ EKL+ LD ++NA+ + + + L+GN + + Sbjct: 137 GSNHISSIKLPKGFPTEKLKVLDFQNNAIHYLSKEDMSSLQQATNLSLNLNGNDIAGIEP 196 Query: 421 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQT-PSENPSLEQLF 479 + + S N ++L + + I L F + P+ L ++ Sbjct: 197 GAF-DSAVFQSLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDMDDEDISPAVFEGLCEMS 255 Query: 480 LGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLT 539 + LQ + + + F S LQ L L +L+ LP G+ L+ L+ L L++N+ Sbjct: 256 VESINLQKHYFFNISSNTFHCFSGLQELDLTATHLSELPSGL-VGLSTLKKLVLSANKFE 314 Query: 540 VLS--HNDLPANLEILDISRN----QLLAPNPDVFVSLSVLDITHNKF---ICECELSTF 590 L +L L I N +L + +L LD++H+ C Sbjct: 315 NLCQISASNFPSLTHLSIKGNTKRLELGTGCLENLENLRELDLSHDDIETSDCCNLQLRN 374 Query: 591 INWLNHTNVTIAGPPADIYCVYP--DSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTV 648 ++ L N++ P + + + L + D + ++L + + Sbjct: 375 LSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKDAQSPFQNLHLLKVLNLSH 434 Query: 649 TL 650 +L Sbjct: 435 SL 436 Score = 72.1 bits (175), Expect = 9e-13, Method: Composition-based stats. Identities = 42/175 (24%), Positives = 69/175 (39%), Gaps = 6/175 (3%) Query: 27 DGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTI 86 D + L L+ + L LS+N ++ +F QL+LL+L + Sbjct: 361 DIETSDCCNLQLRN----LSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKD 416 Query: 87 DKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGL-SDAVLKDGYFRNLK 145 + F+NL L++L+L S + F GL L L L + K + L Sbjct: 417 AQSPFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHLNLQGNHFPKGNIQKTNSLQTLG 476 Query: 146 ALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSF 200 L L LS + S+ +F L + +D S N++ L L+G L+ Sbjct: 477 RLEILVLSFCDLSSID-QHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNL 530 >3WPI-A nrPDB Length = 803 Score = 361 bits (925), Expect = 1e-99, Method: Composition-based stats. Identities = 151/656 (23%), Positives = 259/656 (39%), Gaps = 84/656 (12%) Query: 34 RFCNLTQVPQVLNTT-ERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPL-------- 84 ++ NLT+VP+ L + E LL+S+N I + L L++L++G Sbjct: 186 KYNNLTKVPRQLPPSLEYLLVSYNLIVKLGPEDLAQLTSLRVLDVGGNCRRCDHAPNPCI 245 Query: 85 -------TIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLK 137 + E F +L +L L L S ++ L+ FQGL L L L L +++ Sbjct: 246 ECGQKSLHLHPETFHHLSHLEGLVLKDSSLHTLNSSWFQGLVQLSVLDLSENFLYESITH 305 Query: 138 DGYFRNLKALTRLDLSKNQIRS-----LYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEP 192 F+NL L +L+LS N + L+L SF L SL+ ++ + L+ ++ L Sbjct: 306 TNAFQNLTRLRKLNLSFNYRKKVSFARLHLASSFKNLVSLQELNMNGIFFRLLNKYTLRW 365 Query: 193 LQG-KTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITG------- 244 L L L N ++ + R + L +SG + T Sbjct: 366 LADLPKLHTLHLQMN-FINQAQLSIFGTFRALRFVDLSDNRISGPSTLSEATPEEADDAE 424 Query: 245 --NFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLAR------SSVRHLDLS 296 +A S + + M F D +N + S ++ L LS Sbjct: 425 QEELLSADPHPAPLSTPASKNFMDRCKNFKFTMDLSRNNLVTIKPEMFVQLSRLQCLSLS 484 Query: 297 HGFV-FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL-----GE 350 H + ++N F L +L+VL+L++NK++ ++F L LQ L+LSYN G Sbjct: 485 HNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYNSQPFSMKGI 544 Query: 351 LYSSNF-YGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIF 409 + +F L + + L N I ++ LD N + + + F Sbjct: 545 GHQFSFVTHLSMLQSLSLAHNDIHTRVSSHLNS-NSVRFLDFSGNGMGRMWDEGGLYLHF 603 Query: 410 LSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTP 469 G L L K++L+ N +H+ R +NLD +P L+ ++ + S + Sbjct: 604 FQG--LSGLLKLDLSQNNLHIL--RPQNLD------NLPKSLKLLSLRDNYLSFFNWTSL 653 Query: 470 SENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALR 529 S P+LE L L N L+ L + LQ L ++ N + S+ P F+ L+ Sbjct: 654 SFLPNLEVLDLAGNQLK-----ALTQGTLPNGTLLQKLDVSSNSIVSVVPAFFALAVELK 708 Query: 530 GLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELST 589 ++L+ N L + + + + L+VLD+ N C C + Sbjct: 709 EVNLSHNILKTVDRSWF------------------GPIVMQLTVLDVRSNPLHCACG-AA 749 Query: 590 FINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIV 645 F++ L + G + C P G S+F+ C +E L + F+V Sbjct: 750 FVDLLLEVQTKVPGLANGVKCGSPGQLQGRSIFAQDLRLCLDEV----LSWDEFLV 801 Score = 135 bits (339), Expect = 1e-31, Method: Composition-based stats. Identities = 129/633 (20%), Positives = 212/633 (33%), Gaps = 96/633 (15%) Query: 22 PSCSFDGRIAFYRFCNLTQVPQ-----VLNTTERLLLSFNYIRTVTASSFPFLEQLQLLE 76 P + + L VP+ + RL L N I + S F L L+ L Sbjct: 13 PCELKPHGLVDCNWLFLKSVPRFSAAASCSNITRLSLISNRIHHLHNSDFVHLSNLRQLN 72 Query: 77 LGSQYTP-----------LTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELR 125 L P +TI+ F + L L+L + I + L L Sbjct: 73 LKWNCPPTGLSPLHFSCHMTIEPRTFLAMRTLEELNLSYNGITTVPRL----PSSLVNLS 128 Query: 126 LYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLY-------LHPSFGKLNSLKSIDFS 178 L + VL L +L L + N + L+ L + Sbjct: 129 LSHTNI--LVLDANSLAGLYSLRVLFMDGNCYYKNPCTGAVKVTPGALLGLSQLTHLSLK 186 Query: 179 SNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGW 238 N + V +L + ++ N + D + L +LDV GN Sbjct: 187 YNNLTKVPRQ-----LPPSLEYLLVSYNLIVKLGPEDLAQL------TSLRVLDVGGNCR 235 Query: 239 TVDITGNFSNAISKSQ----AFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLD 294 D N + + H+ G ++ + + F GL + SV LD Sbjct: 236 RCDHAPNPCIECGQKSLHLHPETFHHLSHLEGLVLKDSSLHTLNSSWFQGLVQLSV--LD 293 Query: 295 LSHGFVFS--LNSRVFETLKDLKVLNLAYNKINKIA------DEAFYGLDNLQVLNLSYN 346 LS F++ ++ F+ L L+ LNL++N K++ +F L +LQ LN++ Sbjct: 294 LSENFLYESITHTNAFQNLTRLRKLNLSFNYRKKVSFARLHLASSFKNLVSLQELNMNGI 353 Query: 347 LLGELYS---SNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIP 403 L LPK+ + LQ N I Q F L+ +DL DN ++ + Sbjct: 354 FFRLLNKYTLRWLADLPKLHTLHLQMNFINQAQLSIFGTFRALRFVDLSDNRISGPSTLS 413 Query: 404 SIPDIFLSGNKLVTLPKINL---------TANLIHLSENRLENLDILYF---------LL 445 + L + + N + +N +D+ + Sbjct: 414 EATPEEADDAEQEELLSADPHPAPLSTPASKNFMDRCKNFKFTMDLSRNNLVTIKPEMFV 473 Query: 446 RVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQ 505 ++ LQ L L+ N + +L+ L L N L L W F L LQ Sbjct: 474 QLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLYH-----WKSFSELPQLQ 528 Query: 506 VLYLNHNYLNSLPPG------VFSHLTALRGLSLNSNRL-TVLSHNDLPANLEILDISRN 558 L L++N G +HL+ L+ LSL N + T +S + ++ LD S N Sbjct: 529 ALDLSYNSQPFSMKGIGHQFSFVTHLSMLQSLSLAHNDIHTRVSSHLNSNSVRFLDFSGN 588 Query: 559 QLLAPNPD---------VFVSLSVLDITHNKFI 582 + + L LD++ N Sbjct: 589 GMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLH 621 >5GY2-A nrPDB Length = 455 Score = 359 bits (921), Expect = 3e-99, Method: Composition-based stats. Identities = 154/422 (36%), Positives = 216/422 (51%), Gaps = 11/422 (2%) Query: 20 GIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGS 79 G CS G A L QVP++ + LS N I + +SF L+ LQ L++ Sbjct: 4 GTSECSVIGYNAICINRGLHQVPELPAHVNYVDLSLNSIAELNETSFSRLQDLQFLKVEQ 63 Query: 80 QYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDG 139 Q L I FR L +L IL L ++ L AF GL +L L L C L AVL Sbjct: 64 QTPGLVIRNNTFRGLSSLIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGN 123 Query: 140 YFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLS 199 +F+ L +L L L N I+ + F + +D + N++ +CE +L QGK + Sbjct: 124 FFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLTFNKVKSICEEDLLNFQGKHFT 183 Query: 200 FFSLAANSL--YSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFS 257 L++ +L + + W KC NPF+N + LD+SGNG+ + F +AI+ ++ S Sbjct: 184 LLRLSSITLQDMNEYWLGWEKCGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAGTKIQS 243 Query: 258 LILAH-HIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKV 316 LIL++ + MG+ FG N KDPD TF GL S V+ DLS +F+L VF DL+ Sbjct: 244 LILSNSYNMGSSFGHTNFKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDLEQ 303 Query: 317 LNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQ 376 L LA N+INKI D AF+GL +L LNLS N LG + S F L K+ +DL NHI + Sbjct: 304 LTLAQNEINKIDDNAFWGLTHLLKLNLSQNFLGSIDSRMFENLDKLEVLDLSYNHIRALG 363 Query: 377 DQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLE 436 DQ+F L L+ L L N L ++ I D +L +L KI L N S R++ Sbjct: 364 DQSFLGLPNLKELALDTNQLKSVPD--GIFD------RLTSLQKIWLHTNPWDCSCPRID 415 Query: 437 NL 438 L Sbjct: 416 YL 417 Score = 132 bits (331), Expect = 8e-31, Method: Composition-based stats. Identities = 89/420 (21%), Positives = 146/420 (34%), Gaps = 101/420 (24%) Query: 287 RSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINK-IADEAFYGLDNLQVLNLSY 345 + V ++DLS + LN F L+DL+ L + I + F GL +L +L L Y Sbjct: 29 PAHVNYVDLSLNSIAELNETSFSRLQDLQFLKVEQQTPGLVIRNNTFRGLSSLIILKLDY 88 Query: 346 NLLGELYSSNFYGLPKVAYIDLQKNHI--AIIQDQTFKFLEKLQTLDLRDNALTTIHFIP 403 N +L + F GL + + L + ++ A++ FK L L+ L LRDN + I Sbjct: 89 NQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPAS 148 Query: 404 SIPDIFLSGNKLVTLPKINLTANLIH-LSENRLENLDILYF-LLRVPHLQILILNQNRFS 461 FL+ + L +LT N + + E L N +F LLR+ + + +N+ + Sbjct: 149 ----FFLNMRRFHVL---DLTFNKVKSICEEDLLNFQGKHFTLLRLSSITLQDMNEY-WL 200 Query: 462 SCSGDQTPSENPSLEQLFLGENMLQLAWETELC--------------------------- 494 P +N S+ L L N + + Sbjct: 201 GWEKCGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAGTKIQSLILSNSYNMGSSFGHTN 260 Query: 495 -----WDVFEGL--SHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLP 547 F+GL S ++ L+ + + +L VFSH T L L+L N + + N Sbjct: 261 FKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFW 320 Query: 548 A--------------------------------------------------NLEILDISR 557 NL+ L + Sbjct: 321 GLTHLLKLNLSQNFLGSIDSRMFENLDKLEVLDLSYNHIRALGDQSFLGLPNLKELALDT 380 Query: 558 NQLLAPNPDVFVSLSVLD---ITHNKFICECELSTFI-NWLNHTNVTIAGPPADIYCVYP 613 NQL + +F L+ L + N + C C ++ WLN + G P Sbjct: 381 NQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLSRWLNKNSQKEQGSAKCSGSGKP 440 >3CIG-A nrPDB Length = 697 Score = 347 bits (891), Expect = 1e-95, Method: Composition-based stats. Identities = 178/702 (25%), Positives = 297/702 (42%), Gaps = 103/702 (14%) Query: 23 SCSFDGRIAFYRFCNLTQVPQVLNTTERLL-LSFNYIRTVTASSFPFLEQLQLLELGSQY 81 C+ +A LT +P L + +L L+ N +R + ++F QL +L+ G Sbjct: 1 QCTVRYNVADCSHLKLTHIPDDLPSNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFN- 59 Query: 82 TPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYF 141 + ++ E + LP L++L+L +++ + F +L EL L + +K F Sbjct: 60 SISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHK--IKSNPF 117 Query: 142 RNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFF 201 +N K L +LDLS N + S L N + + N+I + ELE L +L Sbjct: 118 KNQKNLIKLDLSHNGLSSTKLGTGVQLENLQEL-LLAKNKILALRSEELEFLGNSSLRKL 176 Query: 202 SLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILA 261 L++N L C + +L+ + +T +S + +L LA Sbjct: 177 DLSSNPLKEFSP----GCFQTIGKLFALLLNNA--QLNPHLTEKLCWELSNTSIQNLSLA 230 Query: 262 HHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAY 321 ++ + A ++TF+GL +++ LDLS+ + + + F L L+ L+L Y Sbjct: 231 NNQLLAT---------SESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEY 281 Query: 322 NKINKIADEAFYGLDNL---------------------------------QVLNLSYNLL 348 N I +++ +FYGL NL + LN+ N + Sbjct: 282 NNIQRLSPRSFYGLSNLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNI 341 Query: 349 GELYSSNFYGLPKVAYI----------------------------DLQKNHIAIIQDQTF 380 S+ F GL + Y+ +L KNHI+ I + TF Sbjct: 342 PSTKSNTFTGLVSLKYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIANGTF 401 Query: 381 KFLEKLQTLDLRDNALTT------IHFIPSIPDIFLSGNKLVTLP--KINLTANLIHLSE 432 +L +L+ LDL N + + +I +I+LS NK + L L +L L Sbjct: 402 SWLGQLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKYLQLSTSSFALVPSLQRLML 461 Query: 433 NR--LENLDILYFLLR-VPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAW 489 R L+N+DI R + +L IL L+ N ++ + D +LE L N L W Sbjct: 462 RRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDLLEG-LENLEILDFQHNNLARLW 520 Query: 490 ETELCW---DVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHN-- 544 + + +GLSHL +L L N L+ +P GVF +L L+ ++L N L L Sbjct: 521 KRANPGGPVNFLKGLSHLHILNLESNGLDEIPVGVFKNLFELKSINLGLNNLNKLEPFIF 580 Query: 545 DLPANLEILDISRNQLLAPNPDVF----VSLSVLDITHNKFICECE-LSTFINWLNHTNV 599 D +L L++ +N + + DVF +L+ LD+ N F C CE +S F+NW+N T+ Sbjct: 581 DDQTSLRSLNLQKNLITSVEKDVFGPPFQNLNSLDMRFNPFDCTCESISWFVNWINQTHT 640 Query: 600 TIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFS 641 I+ C P + G L T C + ++L F Sbjct: 641 NISELSTHYLCNTPHHYYGFPLKLFDTSSCKDSAPFENLYFQ 682 >3B2D-A nrPDB Length = 603 Score = 343 bits (879), Expect = 2e-94, Method: Composition-based stats. Identities = 141/608 (23%), Positives = 240/608 (39%), Gaps = 47/608 (7%) Query: 33 YRFCNLTQVPQVLN-TTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAF 91 L+++P L TTE L SFN++ T+ +F L L L+L ++ I ++ F Sbjct: 16 CENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDL-TRCQINWIHEDTF 74 Query: 92 RNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLD 151 ++ L L L + + F+ + G L L L G+S+ L+ NL+ L L Sbjct: 75 QSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISN--LEFIPVHNLENLESLY 132 Query: 152 LSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSR 211 L N I S+ F +LK +DF +N I + ++ L+ + N++ Sbjct: 133 LGSNHISSIKFPKDFP-ARNLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVK-- 189 Query: 212 VSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGF 271 G + F + + + L+ G I N+ ++S F Sbjct: 190 -----GIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLG------------TF 232 Query: 272 HNIKDPDQN--TFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIAD 329 +I D D + GL SV L+L ++S F+ L+ L+L + + Sbjct: 233 EDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPS 292 Query: 330 EAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKN-HIAIIQDQTFKFLEKLQT 388 GL+ L+ L LS N +L + P + ++ ++ N + + L LQT Sbjct: 293 G-MKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQT 351 Query: 389 LDLRDNALT-------TIHFIPSIPDIFLSGNKLVTLP----KINLTANLIHLSENRLEN 437 LDL N + + + + + LS N+ + L K L+ L+ RL Sbjct: 352 LDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHI 411 Query: 438 LDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDV 497 + LQ+L L F S + P L L L N Q T+ ++ Sbjct: 412 NAPQSPFQNLHFLQVLNLT-YCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITK--TNL 468 Query: 498 FEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEI-LDIS 556 + + L+VL L+ L S+ F L + + L+ N LT S + L I L+++ Sbjct: 469 LQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLA 528 Query: 557 RNQLLAPNPDVFVSL---SVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYP 613 N + +P + L S ++++HN C C F+ W N+ + C P Sbjct: 529 ANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKE-NLHKLEGSEETTCANP 587 Query: 614 DSFSGVSL 621 S GV L Sbjct: 588 PSLRGVKL 595 Score = 84.1 bits (206), Expect = 3e-16, Method: Composition-based stats. Identities = 80/398 (20%), Positives = 147/398 (36%), Gaps = 45/398 (11%) Query: 293 LDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELY 352 L+ S F+ ++++R F L +L L+L +IN I ++ F L L L+ N L + Sbjct: 35 LEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMA 94 Query: 353 SSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIP------ 406 ++ G + ++ L + I+ ++ LE L++L L N +++I F P Sbjct: 95 ETSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKV 154 Query: 407 -------DIFLSGNKLVTLPK-INLTANL----------------IHLSENRLENLDILY 442 ++S + +L + INL+ N I S N ++ Sbjct: 155 LDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSV 214 Query: 443 FLLRVPHLQILILNQNRFSSCSGDQTPS-ENPSLEQLFLGENMLQLAWETELCWDVFEGL 501 + + L F + S L ++ + LQ +++ F+ Sbjct: 215 IFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCF 274 Query: 502 SHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLS--HNDLPANLEILDISRN- 558 + LQ L L +L LP G+ L L+ L L+ N L +L L I N Sbjct: 275 TQLQELDLTATHLKGLPSGM-KGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNV 333 Query: 559 ---QLLAPNPDVFVSLSVLDITHNKFI----CECELS--TFINWLNHTNVTIAGPPADIY 609 L + +L LD++HN C +L + + LN ++ G + + Sbjct: 334 KKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAF 393 Query: 610 CVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCT 647 P + L + ++L F + T Sbjct: 394 KECP-QLELLDLAFTRLHINAPQSPFQNLHFLQVLNLT 430 >4R08-A nrPDB Length = 811 Score = 332 bits (850), Expect = 6e-91, Method: Composition-based stats. Identities = 149/632 (23%), Positives = 251/632 (39%), Gaps = 71/632 (11%) Query: 42 PQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPL----------------T 85 P++ ++ +L LS I+ ++ F L L LL+L Sbjct: 196 PKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASIN 255 Query: 86 IDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLK 145 ID+ AF+NL LR L+L S+ + ++ F+ + HL L L F L + + L Sbjct: 256 IDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLP 315 Query: 146 ALTRLDLSKNQIRS-----LYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPL-QGKTLS 199 L LDLS N I+ + + +F KL SL+++ + E + +PL Q LS Sbjct: 316 RLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLS 375 Query: 200 FFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLI 259 +L N + K F N LEI+ +S N + + +S A S Sbjct: 376 TINLGINFIKQID----FKLFQNFSN--LEIIYLSENRISPLVKD-----TRQSYANSSS 424 Query: 260 LAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRH--------LDLSHGFVFSLNSRVFETL 311 HI + + + F R ++ LDLS +F + FE L Sbjct: 425 FQRHI--RKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENL 482 Query: 312 KDLKVLNLAYN-KINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKN 370 D+ LNL+ N ++ F + +++ L+L+ N L +S L + +DL N Sbjct: 483 PDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYN 542 Query: 371 HIAIIQDQTFKFL------EKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLT 424 L L+ L+L N + T+ ++ +L ++ + Sbjct: 543 SHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLES--------KSLVELVFS 594 Query: 425 ANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENM 484 N + + N +N I + +L L L+ NR + + SL +L + +NM Sbjct: 595 GNRLDILWNDDDNRYIS-IFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNM 653 Query: 485 LQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHN 544 L+ W + + L++L L N L L + ++LR L L+ NR++ L Sbjct: 654 LK-----FFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSG 708 Query: 545 DLP--ANLEILDISRNQLLAPNPDVFV-----SLSVLDITHNKFICECELSTFINWLNHT 597 L ++L+ LD+S N L N LS+L++ N F C C++ F W++ Sbjct: 709 FLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEH 768 Query: 598 NVTIAGPPADIYCVYPDSFSGVSLFSLSTEGC 629 D+ C P G S+ SL C Sbjct: 769 LNVKIPRLVDVICASPGDQRGKSIVSLELTTC 800 Score = 102 bits (254), Expect = 6e-22, Method: Composition-based stats. Identities = 88/468 (18%), Positives = 168/468 (35%), Gaps = 75/468 (16%) Query: 172 LKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEIL 231 + +D S N I + + LQ L+ +L N + + G N L Sbjct: 43 VTELDLSDNFITHITNESFQGLQN--LTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFL 100 Query: 232 DVS--------------------GNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGF 271 ++ + + + N I+K LI ++ A + Sbjct: 101 NLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCY 160 Query: 272 HNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEA 331 N N G+ + + +L+L SL+ + L+ L L+ +I I++E Sbjct: 161 FNKVCEKTNIEDGVFET-LTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEED 219 Query: 332 FYGLDNLQVLNLSYNLLG-----------------ELYSSNFYGLPKVAYIDLQKNHIAI 374 F GL NL +L+LS N + F L ++ Y++L + Sbjct: 220 FKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRK 279 Query: 375 IQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENR 434 I FK + L+ LDL N L + I S + + L L ++L+ N I + Sbjct: 280 INAAWFKNMPHLKVLDLEFNYL--VGEIASGAFLTM----LPRLEILDLSFNYIK--GSY 331 Query: 435 LENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPS--ENPSLEQLFLGENMLQLAWETE 492 ++++I ++ L+ L L F D + P+L + LG N ++ Sbjct: 332 PQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQID--- 388 Query: 493 LCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANL-- 550 + +F+ S+L+++YL+ N ++ L + + P + Sbjct: 389 --FKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFY 446 Query: 551 ---------------EILDISRNQLLAPNPDVFVSL---SVLDITHNK 580 + LD+S N + P+ F +L + L+++ N Sbjct: 447 HFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANS 494 Score = 82.5 bits (202), Expect = 7e-16, Method: Composition-based stats. Identities = 64/334 (19%), Positives = 115/334 (34%), Gaps = 58/334 (17%) Query: 296 SHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGE----- 350 S+ + + V + + L+L+ N I I +E+F GL NL +NL++N + Sbjct: 28 SNRRLQEVPQTVGKYVT---ELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGN 84 Query: 351 ---------LYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHF 401 + F L + + L+ N + I + L +L + N + I Sbjct: 85 PGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLI---QNNIYNITK 141 Query: 402 IP-----SIPDIFLSGNKLVTL--PKINLTANLIHLSENRLENLDILYFLLRVP-----H 449 ++ +++L+ N K N+ + N L VP Sbjct: 142 EGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSS 201 Query: 450 LQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELC------------WDV 497 L+ L L+ + S + +L L L N + C Sbjct: 202 LRKLFLSNTQIKYISEEDFKGLI-NLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFA 260 Query: 498 FEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSN----RLTVLSHNDLPANLEIL 553 F+ L+ L+ L L+ L + F ++ L+ L L N + + + LEIL Sbjct: 261 FQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEIL 320 Query: 554 DISRNQLLAPNP---------DVFVSLSVLDITH 578 D+S N + P +SL L + Sbjct: 321 DLSFNYIKGSYPQHINISRNFSKLLSLRALHLRG 354 >3V44-A nrPDB Length = 407 Score = 323 bits (827), Expect = 2e-88, Method: Composition-based stats. Identities = 127/355 (35%), Positives = 180/355 (50%), Gaps = 3/355 (0%) Query: 20 GIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGS 79 G CS G A L QVP++ + LS N I + +SF L+ LQ L++ Sbjct: 4 GTSECSVIGYNAICINRGLHQVPELPAHVNYVDLSLNSIAELNETSFSRLQDLQFLKVEQ 63 Query: 80 QYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDG 139 Q L I FR L +L IL L ++ L AF GL +L L L C L AVL Sbjct: 64 QTPGLVIRNNTFRGLSSLIILKLDYNQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGN 123 Query: 140 YFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLS 199 +F+ L +L L L N I+ + F + +D + N++ +CE +L QGK + Sbjct: 124 FFKPLTSLEMLVLRDNNIKKIQPASFFLNMRRFHVLDLTFNKVKSICEEDLLNFQGKHFT 183 Query: 200 FFSLAANSL--YSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFS 257 L++ +L + + W KC NPF+N + LD+SGNG+ + F +AI+ ++ S Sbjct: 184 LLRLSSITLQDMNEYWLGWEKCGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAGTKIQS 243 Query: 258 LILAH-HIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKV 316 LIL++ + MG+ FG N KDPD TF GL S V+ DLS +F+L VF DL+ Sbjct: 244 LILSNSYNMGSSFGHTNFKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDLEQ 303 Query: 317 LNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNH 371 L LA N+INKI D AF+GL +L+ L L N L + F L + I L N Sbjct: 304 LTLAQNEINKIDDNAFWGLTHLKELALDTNQLKSVPDGIFDRLTSLQKIWLHTNP 358 Score = 153 bits (387), Expect = 2e-37, Method: Composition-based stats. Identities = 88/372 (23%), Positives = 146/372 (39%), Gaps = 53/372 (14%) Query: 287 RSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINK-IADEAFYGLDNLQVLNLSY 345 + V ++DLS + LN F L+DL+ L + I + F GL +L +L L Y Sbjct: 29 PAHVNYVDLSLNSIAELNETSFSRLQDLQFLKVEQQTPGLVIRNNTFRGLSSLIILKLDY 88 Query: 346 NLLGELYSSNFYGLPKVAYIDLQKNHI--AIIQDQTFKFLEKLQTLDLRDNALTTIHFIP 403 N +L + F GL + + L + ++ A++ FK L L+ L LRDN + I Sbjct: 89 NQFLQLETGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQPAS 148 Query: 404 SIPDIFLSGNKLVTLPKINLTANLIH-LSENRLENLDILYF-LLRVPHLQILILNQNRFS 461 FL+ + L +LT N + + E L N +F LLR+ + + +N+ + Sbjct: 149 ----FFLNMRRFHVL---DLTFNKVKSICEEDLLNFQGKHFTLLRLSSITLQDMNEY-WL 200 Query: 462 SCSGDQTPSENPSLEQLFLGENMLQLAWETELC--------------------------- 494 P +N S+ L L N + + Sbjct: 201 GWEKCGNPFKNTSITTLDLSGNGFKESMAKRFFDAIAGTKIQSLILSNSYNMGSSFGHTN 260 Query: 495 -----WDVFEGL--SHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLP 547 F+GL S ++ L+ + + +L VFSH T L L+L N + + N Sbjct: 261 FKDPDNFTFKGLEASGVKTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFW 320 Query: 548 A--NLEILDISRNQLLAPNPDVFVSLSVLD---ITHNKFICECELSTFI-NWLNHTNVTI 601 +L+ L + NQL + +F L+ L + N + C C ++ WLN + Sbjct: 321 GLTHLKELALDTNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLSRWLNKNSQKE 380 Query: 602 AGPPADIYCVYP 613 G P Sbjct: 381 QGSAKCSGSGKP 392 >3RG1-A nrPDB Length = 612 Score = 320 bits (819), Expect = 2e-87, Method: Composition-based stats. Identities = 135/623 (21%), Positives = 241/623 (38%), Gaps = 45/623 (7%) Query: 18 VFGIPSCSFD--GRIAFYRFCNLTQVPQVLN-TTERLLLSFNYIRTVTASSFPFLEQLQL 74 P C+ R L ++P L TTE L SFN++ T+ ++F L L Sbjct: 1 AGSDPKCTEKEGNRTYNCENLGLREIPDTLPNTTEVLEFSFNFLPTIQNTTFSRLINLIF 60 Query: 75 LELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDA 134 L+L ++ + ++ F++ L + L + + F+ + G L L L G+S+ Sbjct: 61 LDL-TRCQINWVHEDTFQSHHQLNTIVLTGNPLIFMAETSLTGPKFLKHLFLTQTGISN- 118 Query: 135 VLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQ 194 L+ NL+ L L L N I S+ L +F +LK +DF +N I + + L+ Sbjct: 119 -LEFIPVHNLENLESLHLGSNHISSINLPENFPTQ-NLKVLDFQNNAIHYISRKDTNSLE 176 Query: 195 GKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQ 254 T + N + G F + + + L G+ I N+ +S Sbjct: 177 QATNLSLNFNGNDIK-------GIEPGAFISKIFQSLKFGGSLNLFIIFKGLQNSTLQSL 229 Query: 255 AFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDL 314 F + + TF GL SV ++L L+S F + Sbjct: 230 WLGT----------FEDTDDQYLTSATFEGLCDMSVESINLQKHRFSDLSSSTFRCFTRV 279 Query: 315 KVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKN-HIA 373 + L+L +N + G+++L+ L L+ N +L N P + + ++ N Sbjct: 280 QELDLTAAHLNGLPSG-IEGMNSLKKLVLNANSFDQLCQINAASFPSLRDLYIKGNMRKL 338 Query: 374 IIQDQTFKFLEKLQTLDLRDNALT-------TIHFIPSIPDIFLSGNKLVTLP----KIN 422 + + + LE LQ LDL + + + + + + LS N+ + L K Sbjct: 339 DLGTRCLEKLENLQKLDLSHSDIEASDCCNLQLKNLRHLQYLNLSYNEPLGLEDQAFKEC 398 Query: 423 LTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGE 482 L+ ++ L + L++L L+ S + L L L Sbjct: 399 PQLELLDVAFTHLHVKAPHSPFQNLHLLRVLNLSH-CLLDTSNQHLLAGLQDLRHLNLQG 457 Query: 483 NMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLS 542 N Q ++ ++ + + L++L L+ L S+ F L + L L+ N LT S Sbjct: 458 NSFQDGSISK--TNLLQMVGSLEILILSSCNLLSIDQQAFHGLRNVNHLDLSHNSLTGDS 515 Query: 543 HNDLPANLE-ILDISRNQLLAPNPDVFVSL---SVLDITHNKFICECELSTFINWLNHTN 598 + L L+++ N + P + +L S+++++HN C C FI W N Sbjct: 516 MDALSHLKGLYLNMASNNIRIIPPHLLPALSQQSIINLSHNPLDCTCSNIHFITWYKE-N 574 Query: 599 VTIAGPPADIYCVYPDSFSGVSL 621 + + C P S GV L Sbjct: 575 LHKLEDSEETTCANPPSLRGVKL 597 >3ULU-A nrPDB Length = 694 Score = 317 bits (811), Expect = 2e-86, Method: Composition-based stats. Identities = 167/705 (23%), Positives = 274/705 (38%), Gaps = 103/705 (14%) Query: 16 GPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLL-LSFNYIRTVTASSFPFLEQLQL 74 G C+ +A LTQVP L T +L L+ N +R + A++F QL Sbjct: 4 GSASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTS 63 Query: 75 LELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDA 134 L++G T ++ E + LP L++L+L +++ L F +L EL L + Sbjct: 64 LDVGFN-TISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQK- 121 Query: 135 VLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQ 194 +K+ F K L LDLS N + S L N + S+N+I + EL+ Sbjct: 122 -IKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQEL-LLSNNKIQALKSEELDIFA 179 Query: 195 GKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQ 254 +L L++N + C + + L+ +T ++ + Sbjct: 180 NSSLKKLELSSNQIKEFSP----GCFHAIGRLFGLFLNN--VQLGPSLTEKLCLELANTS 233 Query: 255 AFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDL 314 +L L++ + TF GL +++ LDLS+ + + + F L L Sbjct: 234 IRNLSLSNSQLSTT---------SNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQL 284 Query: 315 KVLNLAYNKI---------------------------------NKIADEAFYGLDNLQVL 341 + L YN I KI D +F L L+ L Sbjct: 285 EYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHL 344 Query: 342 NLSYNLLGELYSSNFYGLPKVAYIDLQK----------------------------NHIA 373 N+ N + + S+ F GL + Y+ L N I+ Sbjct: 345 NMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKIS 404 Query: 374 IIQDQTFKFLEKLQTLDLRDNAL------TTIHFIPSIPDIFLSGNKLVTLPK--INLTA 425 I+ F +L L+ LDL N + + +I +I+LS NK + L + L Sbjct: 405 KIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVP 464 Query: 426 NLIHLSENR--LENLDILYF-LLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGE 482 +L L R L+N+D + +L IL L+ N ++ + D LE L L Sbjct: 465 SLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEG-LEKLEILDLQH 523 Query: 483 NMLQLAWETELCWD---VFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLT 539 N L W+ +GLSHL +L L N + +P VF L L+ + L N L Sbjct: 524 NNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLN 583 Query: 540 VLSHNDL--PANLEILDISRNQLLAPNPDVFV----SLSVLDITHNKFICECE-LSTFIN 592 L + +L+ L++ +N + + VF +L+ LD+ N F C CE ++ F+N Sbjct: 584 TLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVN 643 Query: 593 WLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKS 637 W+N T+ I + C P + G + T C + S Sbjct: 644 WINETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFAS 688 >6GFF-I nrPDB Length = 618 Score = 265 bits (676), Expect = 8e-71, Method: Composition-based stats. Identities = 146/636 (22%), Positives = 230/636 (36%), Gaps = 110/636 (17%) Query: 21 IPSCSFDGRIAFYRFCNLTQVPQVLNT-TERLLLSFNYIRTVTASSFPFLEQLQLLELGS 79 +P D +++ + L QVP VL TE L LS N +R++ AS F L Sbjct: 5 VPCKMVDKKVS-CQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTAL------- 56 Query: 80 QYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAV-LKD 138 R LDL +++I FL P AFQ L HL L L L+ A L Sbjct: 57 ------------------RHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSA 98 Query: 139 GYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTL 198 G L +T LDLS N + S L G+ SL ++ + N + + H + L Sbjct: 99 GGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDM--PAL 156 Query: 199 SFFSLAANSLYSR---------------VSVDWGKCMNPFRNMVLEILDVSGNGWTVDIT 243 L +N L +S + C++ F L +LD+S N Sbjct: 157 EQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEA--- 213 Query: 244 GNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSL 303 F A F L F ++ + +L+LS+ + L Sbjct: 214 --FQTASQPQAEFQLTWLDLRENKLLHFPDLAAL----------PRLIYLNLSNNLI-RL 260 Query: 304 NSRVFETLKDLKVLNLAYNKINKIADE---AFYGLDNLQVLNLSYNLLGELYSSNFYGLP 360 + + K + + ++ + A + L L L+LSYN + + S L Sbjct: 261 PTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLT 320 Query: 361 KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK 420 + +++L +N + + + L L LDL NAL T + L L +L Sbjct: 321 SLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALET---------LELGARALGSLRT 371 Query: 421 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL 480 + L N + Y + LQ L L NR S C G P + + Sbjct: 372 LLLQGNALRDLPP--------YTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCV----- 418 Query: 481 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSN---R 537 F G++ L+ L L N + L G F H T L L L+SN Sbjct: 419 ----------------AFSGITSLRSLSLVDNEIELLRAGAFLH-TPLTELDLSSNPGLE 461 Query: 538 LTVLSHNDLPANLEILDISRNQLLAPNPDV--FVSLSVLDITHNKFICECELSTFINW-- 593 + + L A+LE+L + N L+ D+ F+ L L++ N+ + ++ Sbjct: 462 VATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEV 521 Query: 594 LNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGC 629 L+ N + + P S + L C Sbjct: 522 LDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCC 557 >3A7C-A nrPDB Length = 580 Score = 237 bits (604), Expect = 2e-62, Method: Composition-based stats. Identities = 111/579 (19%), Positives = 214/579 (36%), Gaps = 117/579 (20%) Query: 44 VLNTTERLLLSFNYIRTVTASSFPFLEQLQLLEL-GSQYTPLTIDKEAFRNLPNLRILDL 102 L + E L LS N++ ++++S F L L+ L L G+ Y L + F NL NL+ L + Sbjct: 98 SLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGV-TSLFPNLTNLQTLRI 156 Query: 103 GSSK-IYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLY 161 G+ + + F GL L EL + L + + ++++ + L L ++ S + Sbjct: 157 GNVETFSEIRRIDFAGLTSLNELEIKALSLRN--YQSQSLKSIRDIHHLTLHLSE--SAF 212 Query: 162 LHPSFGK-LNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCM 220 L F L+S++ ++ + + PL +S L R SV + Sbjct: 213 LLEIFADILSSVRYLELRDTN---LARFQFSPLPVDEVSS---PMKKLAFRGSVLTDESF 266 Query: 221 NPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQN 280 N ++ IL++S + + F+ + + Sbjct: 267 NELLKLLRYILELSEVEFDDCTLNGLGD----------------------FNPSESDVVS 304 Query: 281 TFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQV 340 + ++R L + ++F S V+ L+ +K + + +K+ + L +L+ Sbjct: 305 ELGKVETVTIRRLHIPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEF 364 Query: 341 LNLSYNLLGELYSSNFY---GLPKVAYIDLQKNHIAIIQD--QTFKFLEKLQTLDLRDNA 395 L+LS NL+ E Y N P + + L +NH+ +Q + L+ L +LD+ N Sbjct: 365 LDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILLTLKNLTSLDISRNT 424 Query: 396 LTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILIL 455 + P+ + +NL++ I + + + L++L + Sbjct: 425 FHPMPDSCQWPE---------KMRFLNLSSTGIRVVKTCIP-----------QTLEVLDV 464 Query: 456 NQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLN 515 + N S S P L++L++ N L+ + L L V+ + N L Sbjct: 465 SNNNLDSFSL-----FLPRLQELYISRNKLKTLPDASL-------FPVLLVMKIASNQLK 512 Query: 516 SLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLD 575 S+P G+F LT+L+ + L++ Sbjct: 513 SVPDGIFDRLTSLQKIWLHT---------------------------------------- 532 Query: 576 ITHNKFICECELSTFI-NWLNHTNVTIAGPPADIYCVYP 613 N + C C ++ WLN + G P Sbjct: 533 ---NPWDCSCPRIDYLSRWLNKNSQKEQGSAKCSGSGKP 568 Score = 137 bits (344), Expect = 3e-32, Method: Composition-based stats. Identities = 94/454 (20%), Positives = 162/454 (35%), Gaps = 88/454 (19%) Query: 238 WTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSH 297 V IT FS S ++ S + G F +I +GL ++++ LDLS Sbjct: 10 ILVAITVLFSKRCSAQESLSCDASGVCDGRSRSFTSIP-------SGLT-AAMKSLDLSF 61 Query: 298 GFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFY 357 + + +L+VL L ++IN I +AFY L +L+ L+LS N L L SS F Sbjct: 62 NKITYIGHGDLRACANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHLSSLSSSWFG 121 Query: 358 GLPKVAYIDLQKNHIAIIQDQT-FKFLEKLQTLDLRD-NALTTIHF-----IPSIPDIFL 410 L + Y++L N + + F L LQTL + + + I + S+ ++ + Sbjct: 122 PLSSLKYLNLMGNPYQTLGVTSLFPNLTNLQTLRIGNVETFSEIRRIDFAGLTSLNELEI 181 Query: 411 SGNKLVTLPKINL------TANLIHLSENR--LENLDILYFLLRVPHLQILILNQNRFSS 462 L +L +HLSE+ LE + +R L+ L + +FS Sbjct: 182 KALSLRNYQSQSLKSIRDIHHLTLHLSESAFLLEIFADILSSVRYLELRDTNLARFQFSP 241 Query: 463 CSGDQTPSENPSL--------------------EQLFLGE--------------NMLQLA 488 D+ S L L L E N + Sbjct: 242 LPVDEVSSPMKKLAFRGSVLTDESFNELLKLLRYILELSEVEFDDCTLNGLGDFNPSESD 301 Query: 489 WETELCWDVFEGLSHLQV---------------------LYLNHNYLNSLPPGVFSHLTA 527 +EL + L + + + ++ + +P HL + Sbjct: 302 VVSELGKVETVTIRRLHIPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVPCSFSQHLKS 361 Query: 528 LRGLSLNSN-----RLTVLSHNDLPANLEILDISRNQLLAPNPD-----VFVSLSVLDIT 577 L L L+ N L + +L+ L +S+N L + +L+ LDI+ Sbjct: 362 LEFLDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILLTLKNLTSLDIS 421 Query: 578 HNKFICECELSTFINWLNHTNVTIAGPPADIYCV 611 N F + + + N++ G C+ Sbjct: 422 RNTFHPMPDSCQWPEKMRFLNLSSTGIRVVKTCI 455 Score = 31.3 bits (69), Expect = 1.9, Method: Composition-based stats. Identities = 14/78 (17%), Positives = 33/78 (42%), Gaps = 3/78 (3%) Query: 29 RIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDK 88 + NL L + L +S N ++T+ +S + L ++++ S ++ Sbjct: 460 EVLDVSNNNLDSFSLFLPRLQELYISRNKLKTLPDASLFPV--LLVMKIASN-QLKSVPD 516 Query: 89 EAFRNLPNLRILDLGSSK 106 F L +L+ + L ++ Sbjct: 517 GIFDRLTSLQKIWLHTNP 534 >1FYV-A nrPDB Length = 161 Score = 223 bits (567), Expect = 4e-58, Method: Composition-based stats. Identities = 42/164 (25%), Positives = 82/164 (50%), Gaps = 6/164 (3%) Query: 683 PQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIA 742 P ++ A++ +S D WV+N LL +L+ + +C ER+FVPG++ + Sbjct: 3 PLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKE-----GMQICLHERNFVPGKSIVE 57 Query: 743 NIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLM- 801 NI I S K + ++S +F++ WC +A + +++LI++++ + QY + Sbjct: 58 NIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIPS 117 Query: 802 KHQSIRGFVQKQQYLRWPEDFQDVGWFLHKLSQQILKKEKEKKK 845 + ++ + ++ YL WP++ G F L I K E+ K Sbjct: 118 SYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKLTEQAK 161 >5D3I-A nrPDB Length = 568 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 112/512 (21%), Positives = 204/512 (39%), Gaps = 67/512 (13%) Query: 44 VLNTTERLLLSFNYIRTVTASSFPFLEQLQLLEL-GSQYTPLTIDKEAFRNLPNLRILDL 102 L + E L LS N++ ++++S F L L+ L L G+ Y L + F NL NL+ L + Sbjct: 76 SLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNPYQTLGV-TSLFPNLTNLQTLRI 134 Query: 103 GSSK-IYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLY 161 G+ + + F GL L EL + L + + ++++ + L L ++ S + Sbjct: 135 GNVETFSEIRRIDFAGLTSLNELEIKALSLRN--YQSQSLKSIRDIHHLTLHLSE--SAF 190 Query: 162 LHPSFGK-LNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCM 220 L F L+S++ ++ + + PL +S L R SV + Sbjct: 191 LLEIFADILSSVRYLELRDTN---LARFQFSPLPVDEVSS---PMKKLAFRGSVLTDESF 244 Query: 221 NPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQN 280 N ++ IL++S + + F+ + + Sbjct: 245 NELLKLLRYILELSEVEFDDCTLNGLGD----------------------FNPSESDVVS 282 Query: 281 TFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQV 340 + ++R L + ++F S V+ L+ +K + + +K+ + L +L+ Sbjct: 283 ELGKVETVTIRRLHIPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEF 342 Query: 341 LNLSYNLLGELYSSNFY---GLPKVAYIDLQKNHIAIIQD--QTFKFLEKLQTLDLRDNA 395 L+LS NL+ E Y N P + + L +NH+ +Q + L+ L +LD+ N Sbjct: 343 LDLSENLMVEEYLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILLTLKNLTSLDISRNT 402 Query: 396 LTTIHFIPSIPD----IFLSGNKLV--------TLPKINLTANLIH---LSENRLENLDI 440 + P+ + LS + TL ++++ N + L RL+ L I Sbjct: 403 FHPMPDSCQWPEKMRFLNLSSTGIRVVKTCIPQTLEVLDVSNNNLDSFSLFLPRLQELYI 462 Query: 441 LYFLLR-------VPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETEL 493 L+ P L ++ + +N S+ S DQ S P LE L G+N EL Sbjct: 463 SRNKLKTLPDASLFPVLLVMKIRENAVSTFSKDQLGS-FPKLETLEAGDNHF--VCSCEL 519 Query: 494 CWDVFEGLSHLQVL-YLNHNYLNSLPPGVFSH 524 E + Q+L +YL PP + H Sbjct: 520 LSFTMETPALAQILVDWPDSYLCDSPPRLHGH 551 Score = 130 bits (326), Expect = 3e-30, Method: Composition-based stats. Identities = 88/440 (20%), Positives = 156/440 (35%), Gaps = 88/440 (20%) Query: 252 KSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETL 311 ++ S + G F +I +GL ++++ LDLS + + Sbjct: 2 SQESLSCDASGVCDGRSRSFTSIP-------SGLT-AAMKSLDLSFNKITYIGHGDLRAC 53 Query: 312 KDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNH 371 +L+VL L ++IN I +AFY L +L+ L+LS N L L SS F L + Y++L N Sbjct: 54 ANLQVLILKSSRINTIEGDAFYSLGSLEHLDLSDNHLSSLSSSWFGPLSSLKYLNLMGNP 113 Query: 372 IAIIQDQT-FKFLEKLQTLDLRD-NALTTIHF-----IPSIPDIFLSGNKLVTLPKINL- 423 + + F L LQTL + + + I + S+ ++ + L +L Sbjct: 114 YQTLGVTSLFPNLTNLQTLRIGNVETFSEIRRIDFAGLTSLNELEIKALSLRNYQSQSLK 173 Query: 424 -----TANLIHLSENR--LENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSL- 475 +HLSE+ LE + +R L+ L + +FS D+ S L Sbjct: 174 SIRDIHHLTLHLSESAFLLEIFADILSSVRYLELRDTNLARFQFSPLPVDEVSSPMKKLA 233 Query: 476 -------------------EQLFLGE--------------NMLQLAWETELCWDVFEGLS 502 L L E N + +EL + Sbjct: 234 FRGSVLTDESFNELLKLLRYILELSEVEFDDCTLNGLGDFNPSESDVVSELGKVETVTIR 293 Query: 503 HLQV---------------------LYLNHNYLNSLPPGVFSHLTALRGLSLNSN----- 536 L + + + ++ + +P HL +L L L+ N Sbjct: 294 RLHIPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEE 353 Query: 537 RLTVLSHNDLPANLEILDISRNQLLAPNPD-----VFVSLSVLDITHNKFICECELSTFI 591 L + +L+ L +S+N L + +L+ LDI+ N F + + Sbjct: 354 YLKNSACKGAWPSLQTLVLSQNHLRSMQKTGEILLTLKNLTSLDISRNTFHPMPDSCQWP 413 Query: 592 NWLNHTNVTIAGPPADIYCV 611 + N++ G C+ Sbjct: 414 EKMRFLNLSSTGIRVVKTCI 433 >2J67-A nrPDB Length = 178 Score = 212 bits (540), Expect = 4e-55, Method: Composition-based stats. Identities = 36/147 (24%), Positives = 75/147 (51%), Gaps = 4/147 (2%) Query: 692 KYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNS 751 ++ A++ +S D WV+N L+ +L+ + +C E F PG++ NI I S Sbjct: 35 RFHAFISYSEHDSLWVKNELIPNLEKE---DGSILICLYESYFDPGKSISENIVSFIEKS 91 Query: 752 RKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLM-KHQSIRGFV 810 K + ++S +F+++ WC F +A + + +I++++ + Y + ++ ++ + Sbjct: 92 YKSIFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALL 151 Query: 811 QKQQYLRWPEDFQDVGWFLHKLSQQIL 837 +K+ YL WP+D + G F L I Sbjct: 152 EKKAYLEWPKDRRKCGLFWANLRAAIN 178 >4OM7-A nrPDB Length = 179 Score = 210 bits (535), Expect = 2e-54, Method: Composition-based stats. Identities = 36/159 (22%), Positives = 83/159 (52%), Gaps = 6/159 (3%) Query: 692 KYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNS 751 ++ A++ +S D WV++ L+ +L+ + +C ER+FVPG++ + NI + I S Sbjct: 2 QFHAFISYSEHDSAWVKSELVPYLEKE-----DIQICLHERNFVPGKSIVENIINCIEKS 56 Query: 752 RKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLM-KHQSIRGFV 810 K + ++S +F++ WC +A + ++ LI++++ + Q + K+ ++ + Sbjct: 57 YKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALM 116 Query: 811 QKQQYLRWPEDFQDVGWFLHKLSQQILKKEKEKKKDNNI 849 ++ YL+WP++ G F + K ++N++ Sbjct: 117 TQRTYLQWPKEKSKRGLFWANIRAAFNMKLTLVTENNDV 155 >2Z7X-A nrPDB Length = 549 Score = 208 bits (530), Expect = 7e-54, Method: Composition-based stats. Identities = 117/607 (19%), Positives = 219/607 (36%), Gaps = 133/607 (21%) Query: 60 TVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLF 119 ++ + E ++ L+L + I + NL+ L L S+ I + D+F L Sbjct: 16 SLNSIPSGLTEAVKSLDLSNNRITY-ISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLG 74 Query: 120 HLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSS 179 L L L + LS+ L +F+ L +LT L+L N ++L F L L+ + + Sbjct: 75 SLEHLDLSYNYLSN--LSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGN 132 Query: 180 NQIFLVCEHE-------LEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEIL- 231 F + + LE L+ S SL S +V ++LEI Sbjct: 133 MDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFV 192 Query: 232 DVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTF--------- 282 DV+ + +++ + S+ + + F F N+K D++ F Sbjct: 193 DVTSSVECLELRDTDLDTFHFSEL--STGETNSLIKKFTFRNVKITDESLFQVMKLLNQI 250 Query: 283 ---------------AGLARSS---------------VRHLDLSHGFVFSLNSRVFETLK 312 G R+S +R L + ++F S ++ + Sbjct: 251 SGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTE 310 Query: 313 DLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNF---YGLPKVAYIDLQK 369 +K + + +K+ + L +L+ L+LS NL+ E Y N P + + L++ Sbjct: 311 RVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQ 370 Query: 370 NHIAIIQD--QTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANL 427 NH+A ++ +T L+ L +D+ N+ ++ P+ + +NL++ Sbjct: 371 NHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPE---------KMKYLNLSSTR 421 Query: 428 IHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQL 487 IH + L+IL + S+ + + P L++L++ N L Sbjct: 422 IHSVTGCIP-----------KTLEILDV-----SNNNLNLFSLNLPQLKELYISRNKLMT 465 Query: 488 AWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLP 547 + L L L VL ++ N L S+P G+F LT+L+ + L++ Sbjct: 466 LPDASL-------LPMLLVLKISRNQLKSVPDGIFDRLTSLQKIWLHT------------ 506 Query: 548 ANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFI-NWLNHTNVTIAGPPA 606 N + C C ++ WLN + G Sbjct: 507 -------------------------------NPWDCSCPRIDYLSRWLNKNSQKEQGSAK 535 Query: 607 DIYCVYP 613 P Sbjct: 536 CSGSGKP 542 Score = 138 bits (347), Expect = 1e-32, Method: Composition-based stats. Identities = 63/278 (22%), Positives = 119/278 (42%), Gaps = 27/278 (9%) Query: 255 AFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDL 314 + S G+ ++I +GL + V+ LDLS+ + +++ + +L Sbjct: 1 SLSCDRNGICKGSSGSLNSIP-------SGLTEA-VKSLDLSNNRITYISNSDLQRCVNL 52 Query: 315 KVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAI 374 + L L N IN I +++F L +L+ L+LSYN L L SS F L + +++L N Sbjct: 53 QALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKT 112 Query: 375 IQDQT-FKFLEKLQTLDLRD-NALTTIHF-----IPSIPDIFLSGNKLVTLPKINLTA-- 425 + + + F L KLQ L + + + T I + + ++ + + L + +L + Sbjct: 113 LGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQ 172 Query: 426 NLIHLSENRLENLDILYFLLRVP------HLQILILNQNRFSSCSGDQTPSENPSLEQLF 479 N+ HL + +++ +L + V L+ L+ FS S +T S L + F Sbjct: 173 NVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNS----LIKKF 228 Query: 480 LGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSL 517 N+ + +S L L + LN + Sbjct: 229 TFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGV 266 >1O77-A nrPDB Length = 146 Score = 200 bits (509), Expect = 2e-51, Method: Composition-based stats. Identities = 41/145 (28%), Positives = 74/145 (51%), Gaps = 4/145 (2%) Query: 693 YDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSR 752 YDA++ +S +D WV+N +++ L+ + F LC +RDF+PG+ I NI D+I S Sbjct: 3 YDAFVSYSERDAYWVENLMVQELE---NFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSH 59 Query: 753 KIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLM-KHQSIRGFVQ 811 K V ++S +F++ W ++ R + N A I++++ + + + + +R + Sbjct: 60 KTVFVLSENFVKSEWSKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMN 119 Query: 812 KQQYLRWPEDFQDVGWFLHKLSQQI 836 + YL WP D F L I Sbjct: 120 TKTYLEWPMDEAQREGFWVNLRAAI 144 >4QDH-A nrPDB Length = 438 Score = 193 bits (490), Expect = 3e-49, Method: Composition-based stats. Identities = 87/367 (23%), Positives = 152/367 (41%), Gaps = 32/367 (8%) Query: 261 AHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV-FSLNSRVFETLKDLKVLNL 319 + +N+ F L+R ++ L LSH + ++N F L +L+VL+L Sbjct: 58 LTQLTKLSLSRNNLVTIKPEMFVNLSR--LQCLSLSHNSIAQAVNGSQFLPLTNLQVLDL 115 Query: 320 AYNKINKIADEAFYGLDNLQVLNLSYNLL-----GELYSSNF-YGLPKVAYIDLQKNHIA 373 ++NK++ ++F L LQ L+LSYN G ++ +F L + + L N I Sbjct: 116 SHNKLDLYHWKSFSELPQLQALDLSYNSQPFSMKGIGHNFSFVTHLSMLQSLSLAHNDIH 175 Query: 374 IIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSEN 433 ++ LD N + + + F G L L K++L+ N +H+ Sbjct: 176 TRVSSHLNS-NSVRFLDFSGNGMGRMWDEGGLYLHFFQG--LSGLLKLDLSQNNLHIL-- 230 Query: 434 RLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETEL 493 R +NLD +P L+ ++ + S + S P+LE L L N L+ L Sbjct: 231 RPQNLD------NLPKSLKLLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLK-----AL 279 Query: 494 CWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLS---HNDLPANL 550 + LQ L ++ N + S+ P F+ L+ ++L+ N L + + NL Sbjct: 280 TNGTLPNGTLLQKLDVSSNSIVSVVPAFFALAVELKEVNLSHNILKTVDRSWFGPIVMNL 339 Query: 551 EILDISRNQLLAPNPDVFVSLSVLD---ITHNKFICECELSTFI-NWLNHTNVTIAGPPA 606 + L + NQL + +F L+ L + N + C C ++ WLN + G Sbjct: 340 KELALDTNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLSRWLNKNSQKEQGSAK 399 Query: 607 DIYCVYP 613 P Sbjct: 400 CSGSGKP 406 Score = 109 bits (272), Expect = 5e-24, Method: Composition-based stats. Identities = 80/384 (20%), Positives = 133/384 (34%), Gaps = 55/384 (14%) Query: 22 PSCSFDGRIAFYRFCNLTQVPQVLNTT-------------------------ERLLLSFN 56 CS G LT VP + ++ +L LS N Sbjct: 10 SRCSCSGTEIRCNSKGLTSVPTGIPSSATRLELESNKLQSLPHGVFDKLTQLTKLSLSRN 69 Query: 57 YIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQ 116 + T+ F L +LQ L L ++ F L NL++LDL +K+ H +F Sbjct: 70 NLVTIKPEMFVNLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWKSFS 129 Query: 117 GLFHLFELRLYFC----GLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSL 172 L L L L + + + +L L L L+ N I + S NS+ Sbjct: 130 ELPQLQALDLSYNSQPFSMKGIGHNFSFVTHLSMLQSLSLAHNDIHTR--VSSHLNSNSV 187 Query: 173 KSIDFSSNQIFLVCEHELEPLQ----GKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVL 228 + +DFS N + + + L L L+ N+L+ + + + L Sbjct: 188 RFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQNLDNLPKSLKLLSL 247 Query: 229 EILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARS 288 +S WT SL ++ + +K T + Sbjct: 248 RDNYLSFFNWT-----------------SLSFLPNLEVLDLAGNQLKALTNGTLPN--GT 288 Query: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLD-NLQVLNLSYNL 347 ++ LD+S + S+ F +LK +NL++N + + F + NL+ L L N Sbjct: 289 LLQKLDVSSNSIVSVVPAFFALAVELKEVNLSHNILKTVDRSWFGPIVMNLKELALDTNQ 348 Query: 348 LGELYSSNFYGLPKVAYIDLQKNH 371 L + F L + I L N Sbjct: 349 LKSVPDGIFDRLTSLQKIWLHTNP 372 >5LFN-A nrPDB Length = 337 Score = 187 bits (474), Expect = 2e-47, Method: Composition-based stats. Identities = 85/351 (24%), Positives = 144/351 (41%), Gaps = 45/351 (12%) Query: 292 HLDLSHGFVFSLN-SRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGE 350 H DL H + ++ + + K+LNL N +A +F + NL L+L + + E Sbjct: 8 HSDLQHVICDKVGLQKIPKVSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQHCQIRE 67 Query: 351 LYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHF-----IPSI 405 + + F GL ++ Y+ L N I +++ F L +L L L N +T + + ++ Sbjct: 68 VAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTELPRGLLSPLVNL 127 Query: 406 PDIFLSGNKLVTLPKINLTA----NLIHLSENRLENLDILYFLLRVPHLQILILNQNRFS 461 + L+ NK+ L ++LSEN L +L L V +L +++N+ S Sbjct: 128 FILQLNNNKIRELRAGAFQGAKDLRWLYLSENALSSLQP-GALDDVENLAKFHVDRNQLS 186 Query: 462 SCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGL-SHLQVLYLNHNYLNSLPPG 520 S S+ +E+L L N L+ + + F+ +L+ L+L++ L G Sbjct: 187 SYPSAAL-SKLRVVEELKLSHNPLK-----SIPDNAFQSFGRYLETLWLDNTNLEKFSDG 240 Query: 521 VFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNK 580 F +T L+ + L +NRL L N F SL L +T+N Sbjct: 241 AFLGVTTLKHVHLENNRLNQLPSNF---------------------PFDSLETLALTNNP 279 Query: 581 FICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLST-EGCD 630 + C C+L WL + P D C P F G + C Sbjct: 280 WKCTCQLRGLRRWL---EAKASRP--DATCASPAKFKGQHIRDTDAFRSCK 325 Score = 94.1 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 101/299 (33%), Gaps = 27/299 (9%) Query: 24 CSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTP 83 C D + L ++P+V T+ L L N + A+SF + L L L Sbjct: 7 CHSDLQHVICDKVGLQKIPKVSEKTKLLNLQRNNFPVLAANSFRAMPNLVSLHLQH-CQI 65 Query: 84 LTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRN 143 + AFR L L L L + I L AF L L L L +++ L G Sbjct: 66 REVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVTE--LPRGLLSP 123 Query: 144 LKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSL 203 L L L L+ N+IR L +F L+ + S N L LQ L Sbjct: 124 LVNLFILQLNNNKIRELR-AGAFQGAKDLRWLYLSENA--------LSSLQPGALDDVEN 174 Query: 204 AANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHH 263 A R + + V+E L +S N F + Sbjct: 175 LAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQ-----------SFGRY 223 Query: 264 IMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN 322 + N++ F G+ +++H+ L + + L S L+ L L N Sbjct: 224 LETLWLDNTNLEKFSDGAFLGVT--TLKHVHLENNRLNQLPSNF--PFDSLETLALTNN 278 >2Z80-A nrPDB Length = 353 Score = 174 bits (440), Expect = 2e-43, Method: Composition-based stats. Identities = 80/381 (20%), Positives = 146/381 (38%), Gaps = 71/381 (18%) Query: 249 AISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVF 308 S + S G+ ++I +GL + V+ LDLS+ + +++ Sbjct: 21 ESSNQASLSCDRNGICKGSSGSLNSIP-------SGLTEA-VKSLDLSNNRITYISNSDL 72 Query: 309 ETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQ 368 + +L+ L L N IN I +++F L +L+ L+LSYN L L SS F L + +++L Sbjct: 73 QRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLL 132 Query: 369 KNHIAIIQDQT-FKFLEKLQTLDLRD-NALTTIHF-----IPSIPDIFLSGNKLVTLPKI 421 N + + + F L KLQ L + + + T I + + ++ + + L + Sbjct: 133 GNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPK 192 Query: 422 NLTA--NLIHLSENRLENLDILYFLLRVP------HLQILILNQNRFSSCSGDQTPSENP 473 +L + N+ HL + +++ +L + V L+ L+ FS S +T S Sbjct: 193 SLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNS--- 249 Query: 474 SLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSL 533 L + F N+ + +S L L + N L S+P G+F LT+L+ + L Sbjct: 250 -LIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFSRNQLKSVPDGIFDRLTSLQKIWL 308 Query: 534 NSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFI-N 592 ++ N + C C ++ Sbjct: 309 HT-------------------------------------------NPWDCSCPRIDYLSR 325 Query: 593 WLNHTNVTIAGPPADIYCVYP 613 WLN + G P Sbjct: 326 WLNKNSQKEQGSAKCSGSGKP 346 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 60/275 (21%), Positives = 110/275 (40%), Gaps = 17/275 (6%) Query: 60 TVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLF 119 ++ + E ++ L+L + I + NL+ L L S+ I + D+F L Sbjct: 42 SLNSIPSGLTEAVKSLDLSNNRITY-ISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLG 100 Query: 120 HLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSS 179 L L L + LS+ L +F+ L +LT L+L N ++L F L L+ + + Sbjct: 101 SLEHLDLSYNYLSN--LSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGN 158 Query: 180 NQIFLVCEHE-------LEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEIL- 231 F + + LE L+ S SL S +V ++LEI Sbjct: 159 MDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFV 218 Query: 232 DVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLAR---- 287 DV+ + +++ + S+ + + F F N+K D++ F + Sbjct: 219 DVTSSVECLELRDTDLDTFHFSEL--STGETNSLIKKFTFRNVKITDESLFQVMKLLNQI 276 Query: 288 SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN 322 S + L+ S + S+ +F+ L L+ + L N Sbjct: 277 SGLLELEFSRNQLKSVPDGIFDRLTSLQKIWLHTN 311 Score = 77.5 bits (189), Expect = 2e-14, Method: Composition-based stats. Identities = 45/215 (20%), Positives = 82/215 (38%), Gaps = 7/215 (3%) Query: 43 QVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDL 102 L + E L LS+NY+ +++S F L L L L + F +L L+IL + Sbjct: 97 SSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRV 156 Query: 103 GS-SKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLY 161 G+ + F GL L EL + L + ++++ ++ L L Q + Sbjct: 157 GNMDTFTKIQRKDFAGLTFLEELEIDASDL--QSYEPKSLKSIQNVSHLILHMKQH--IL 212 Query: 162 LHPSFGKL-NSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCM 220 L F + +S++ ++ + EL + +L N + S+ + Sbjct: 213 LLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKL 272 Query: 221 NPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQA 255 + +LE L+ S N G F S + Sbjct: 273 LNQISGLLE-LEFSRNQLKSVPDGIFDRLTSLQKI 306 >2FT3-A nrPDB Length = 332 Score = 159 bits (401), Expect = 5e-39, Method: Composition-based stats. Identities = 67/276 (24%), Positives = 114/276 (41%), Gaps = 29/276 (10%) Query: 293 LDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELY 352 LDL + + L F+ L+ L L L NKI+KI ++AF L LQ L +S N L E+ Sbjct: 59 LDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIP 118 Query: 353 SSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSG 412 + + + + N I + F L + +++ N L F P D Sbjct: 119 PNLPS---SLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFD----- 170 Query: 413 NKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSEN 472 L N + +SE +L + L L L+ N+ + + + Sbjct: 171 ---------GLKLNYLRISEAKLTGIPKDLP----ETLNELHLDHNKIQAIELEDLLRYS 217 Query: 473 PSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLS 532 L +L LG N +++ L + L L+ L+L++N L+ +P G+ L L+ + Sbjct: 218 -KLYRLGLGHNQIRMIENGSLSF-----LPTLRELHLDNNKLSRVPAGL-PDLKLLQVVY 270 Query: 533 LNSNRLTVLSHNDL-PANLEILDISRNQLLAPNPDV 567 L++N +T + ND P + N + N V Sbjct: 271 LHTNNITKVGVNDFCPVGFGVKRAYYNGISLFNNPV 306 Score = 98.7 bits (244), Expect = 9e-21, Method: Composition-based stats. Identities = 59/303 (19%), Positives = 104/303 (34%), Gaps = 55/303 (18%) Query: 80 QYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDG 139 Q + L + P+ +LDL ++ I L D F+GL HL+ L L +S + + Sbjct: 39 QCSDLGLKAVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISK--IHEK 96 Query: 140 YFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLS 199 F L+ L +L +SKN + + + P+ SL + N+I V + L+ ++ Sbjct: 97 AFSPLRKLQKLYISKNHL--VEIPPNLPS--SLVELRIHDNRIRKVPKGVFSGLRN--MN 150 Query: 200 FFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLI 259 + N L + F + L L +S T Sbjct: 151 CIEMGGNPLENSGFEP-----GAFDGLKLNYLRISEAKLTGIP----------------- 188 Query: 260 LAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNL 319 L + + L L H + ++ L L L Sbjct: 189 -----------------------KDLPET-LNELHLDHNKIQAIELEDLLRYSKLYRLGL 224 Query: 320 AYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQT 379 +N+I I + + L L+ L+L N L + + L + + L N+I + Sbjct: 225 GHNQIRMIENGSLSFLPTLRELHLDNNKLSRVPAGLPD-LKLLQVVYLHTNNITKVGVND 283 Query: 380 FKF 382 F Sbjct: 284 FCP 286 Score = 79.8 bits (195), Expect = 5e-15, Method: Composition-based stats. Identities = 58/318 (18%), Positives = 106/318 (33%), Gaps = 69/318 (21%) Query: 24 CSFDGRIAFYRFCNLTQVPQVLNT-TERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYT 82 C R+ L VP+ ++ T L L N I + F L+ L Sbjct: 31 CHCHLRVVQCSDLGLKAVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLY--------- 81 Query: 83 PLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFR 142 L L ++KI +H AF Sbjct: 82 ----------------ALVLVNNKISKIHEKAFS-------------------------- 99 Query: 143 NLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFS 202 L+ L +L +SKN + + + P+ SL + N+I V + L+ ++ Sbjct: 100 PLRKLQKLYISKNHL--VEIPPNLPS--SLVELRIHDNRIRKVPKGVFSGLRN--MNCIE 153 Query: 203 LAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFS------NAISKSQAF 256 + N L + + + L I + G D+ + N I + Sbjct: 154 MGGNPLENSGFEP--GAFDGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELE 211 Query: 257 SLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKV 316 L+ + G G + I+ + + + L ++R L L + + + + + + LK L+V Sbjct: 212 DLLRYSKLYRLGLGHNQIRMIENGSLSFLP--TLRELHLDNNKLSRVPAGLPD-LKLLQV 268 Query: 317 LNLAYNKINKIADEAFYG 334 + L N I K+ F Sbjct: 269 VYLHTNNITKVGVNDFCP 286 Score = 71.4 bits (173), Expect = 2e-12, Method: Composition-based stats. Identities = 49/222 (22%), Positives = 82/222 (36%), Gaps = 15/222 (6%) Query: 376 QDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK-INLTANLIHLSENR 434 +T + L +L +A+ + + S L +PK I+ L+ L N Sbjct: 6 GAETTSGIPDLDSLPPTYSAMCPFGCHCHLRVVQCSDLGLKAVPKEISPDTTLLDLQNND 65 Query: 435 LENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELC 494 + L + HL L+L N+ S S L++L++ +N L Sbjct: 66 ISELR-KDDFKGLQHLYALVLVNNKISKIHEKAF-SPLRKLQKLYISKNHLVEIPP---- 119 Query: 495 WDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVL---SHNDLPANLE 551 S L L ++ N + +P GVFS L + + + N L L Sbjct: 120 ----NLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLN 175 Query: 552 ILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINW 593 L IS +L D+ +L+ L + HNK EL + + Sbjct: 176 YLRISEAKLTGIPKDLPETLNELHLDHNKIQ-AIELEDLLRY 216 Score = 50.9 bits (120), Expect = 3e-06, Method: Composition-based stats. Identities = 33/134 (24%), Positives = 54/134 (40%), Gaps = 3/134 (2%) Query: 507 LYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPA--NLEILDISRNQLLAPN 564 L L +N ++ L F L L L L +N+++ + L+ L IS+N L+ Sbjct: 59 LDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIP 118 Query: 565 PDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSL 624 P++ SL L I N+ + F N + + G P + P +F G+ L L Sbjct: 119 PNLPSSLVELRIHDNRI-RKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYL 177 Query: 625 STEGCDEEEVLKSL 638 + K L Sbjct: 178 RISEAKLTGIPKDL 191 >4R6F-A nrPDB Length = 331 Score = 158 bits (400), Expect = 7e-39, Method: Composition-based stats. Identities = 84/282 (29%), Positives = 126/282 (44%), Gaps = 20/282 (7%) Query: 288 SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNL 347 +VR+L L + + + L +L LNL+ N++ + F L NL LNLS N Sbjct: 63 PNVRYLALGGNKLHDI--SALKELTNLGWLNLSNNQLETLPQGVFEKLTNLTTLNLSNNQ 120 Query: 348 LGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIH--FIPSI 405 L L F L + ++L N+IA I DQ + L L TL+L N L + P Sbjct: 121 LTSLPQGVFERLASLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGG 180 Query: 406 PDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSG 465 P FL G L L +NL++N + + L L L+ N ++ Sbjct: 181 PIYFLKG--LTNLTTLNLSSNGFDEIPREV--------FKDLTSLTTLNLSNNNIANI-N 229 Query: 466 DQTPSENPSLEQLFLGENMLQLAWETELCWD---VFEGLSHLQVLYLNHNYLNSLPPGVF 522 DQ +L L L N L W+ +GL++L L L+ N + +P VF Sbjct: 230 DQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVF 289 Query: 523 SHLTALRGLSLNSNRLTVLSHNDLPA--NLEILDISRNQLLA 562 LT+L L+L++N+LT L NL+ L++S NQL + Sbjct: 290 KDLTSLTTLNLSNNQLTSLPQGVFERLTNLKTLNLSNNQLQS 331 Score = 140 bits (352), Expect = 3e-33, Method: Composition-based stats. Identities = 87/350 (24%), Positives = 148/350 (42%), Gaps = 51/350 (14%) Query: 57 YIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQ 116 ++ + + +L ++ + + LPN+R L LG +K++ + A + Sbjct: 25 NLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQYLPNVRYLALGGNKLHDI--SALK 82 Query: 117 GLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSID 176 L +L L L L L G F L LT L+LS NQ+ SL F +L SL +++ Sbjct: 83 ELTNLGWLNLSNNQL--ETLPQGVFEKLTNLTTLNLSNNQLTSL-PQGVFERLASLTTLN 139 Query: 177 FSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGN 236 S+N I + + LE L L+ +L+ N+L K NP + L N Sbjct: 140 LSNNNIANINDQMLEGLTN--LTTLNLSHNNLARL-----WKHANPGG--PIYFLKGLTN 190 Query: 237 GWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLS 296 T++++ N + I + F L S+ L+LS Sbjct: 191 LTTLNLSSNGFDEIP---------------------------REVFKDLT--SLTTLNLS 221 Query: 297 HGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEA--------FYGLDNLQVLNLSYNLL 348 + + ++N ++ E L +L LNL++N + ++ A GL NL LNLS N Sbjct: 222 NNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGF 281 Query: 349 GELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTT 398 E+ F L + ++L N + + F+ L L+TL+L +N L + Sbjct: 282 DEIPREVFKDLTSLTTLNLSNNQLTSLPQGVFERLTNLKTLNLSNNQLQS 331 Score = 108 bits (269), Expect = 1e-23, Method: Composition-based stats. Identities = 71/307 (23%), Positives = 122/307 (39%), Gaps = 26/307 (8%) Query: 25 SFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPL 84 S D IA Q Q L L L N + ++A L L L L + Sbjct: 42 SIDQIIANNSDIKSVQGIQYLPNVRYLALGGNKLHDISA--LKELTNLGWLNLSNN-QLE 98 Query: 85 TIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNL 144 T+ + F L NL L+L ++++ L F+ L L L L +++ + D L Sbjct: 99 TLPQGVFEKLTNLTTLNLSNNQLTSLPQGVFERLASLTTLNLSNNNIAN--INDQMLEGL 156 Query: 145 KALTRLDLSKNQIRSL-------YLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKT 197 LT L+LS N + L L +L +++ SSN + + L + Sbjct: 157 TNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLT--S 214 Query: 198 LSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFS 257 L+ +L+ N++ + N L L++S N ++ + +A + Sbjct: 215 LTTLNLSNNNIANINDQMLEGLTN------LTTLNLSHN----NLARLWKHANPGGPIYF 264 Query: 258 LILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVL 317 L ++ + + + F L S+ L+LS+ + SL VFE L +LK L Sbjct: 265 LKGLTNLTTLNLSSNGFDEIPREVFKDLT--SLTTLNLSNNQLTSLPQGVFERLTNLKTL 322 Query: 318 NLAYNKI 324 NL+ N++ Sbjct: 323 NLSNNQL 329 Score = 90.2 bits (222), Expect = 4e-18, Method: Composition-based stats. Identities = 60/236 (25%), Positives = 101/236 (42%), Gaps = 25/236 (10%) Query: 370 NHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPD---IFLSGNKLVTLPKINL--- 423 N+ I Q ++L ++ L L N L I + + + + LS N+L TLP+ Sbjct: 49 NNSDIKSVQGIQYLPNVRYLALGGNKLHDISALKELTNLGWLNLSNNQLETLPQGVFEKL 108 Query: 424 -TANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGE 482 ++LS N+L +L R+ L L L+ N ++ DQ +L L L Sbjct: 109 TNLTTLNLSNNQLTSLP-QGVFERLASLTTLNLSNNNIANI-NDQMLEGLTNLTTLNLSH 166 Query: 483 NMLQLAWETELCWD---VFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLT 539 N L W+ +GL++L L L+ N + +P VF LT+L L+L++N + Sbjct: 167 NNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNNIA 226 Query: 540 VLSHNDLPA--NLEILDISRNQLLAPNPDV-----------FVSLSVLDITHNKFI 582 ++ L NL L++S N L +L+ L+++ N F Sbjct: 227 NINDQMLEGLTNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFD 282 Score = 76.4 bits (186), Expect = 5e-14, Method: Composition-based stats. Identities = 49/218 (22%), Positives = 76/218 (34%), Gaps = 44/218 (20%) Query: 34 RFCNLTQVPQ----VLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPL----- 84 LT +PQ L + L LS N I + L L L L Sbjct: 117 SNNQLTSLPQGVFERLASLTTLNLSNNNIANINDQMLEGLTNLTTLNLSHNNLARLWKHA 176 Query: 85 --------------------------TIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGL 118 I +E F++L +L L+L ++ I ++ +GL Sbjct: 177 NPGGPIYFLKGLTNLTTLNLSSNGFDEIPREVFKDLTSLTTLNLSNNNIANINDQMLEGL 236 Query: 119 FHLFELRLYFCGLSDAVLKDGY------FRNLKALTRLDLSKNQIRSLYLHPSFGKLNSL 172 +L L L L+ + L LT L+LS N + F L SL Sbjct: 237 TNLTTLNLSHNNLARLWKHANPGGPIYFLKGLTNLTTLNLSSNGFDEI-PREVFKDLTSL 295 Query: 173 KSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYS 210 +++ S+NQ+ + + E L L +L+ N L S Sbjct: 296 TTLNLSNNQLTSLPQGVFERLTN--LKTLNLSNNQLQS 331 >1XCD-A nrPDB Length = 329 Score = 139 bits (349), Expect = 6e-33, Method: Composition-based stats. Identities = 64/258 (24%), Positives = 112/258 (43%), Gaps = 25/258 (9%) Query: 293 LDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELY 352 LDL + + + F+ LK+L L L NKI+KI+ AF L L+ L LS N L EL Sbjct: 57 LDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELP 116 Query: 353 SSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPD----- 407 + + + +N I ++ F L ++ ++L N L + Sbjct: 117 EKMP---KTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKL 173 Query: 408 --IFLSGNKLVTLPK-INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCS 464 I ++ + T+P+ + + +HL N++ +D L + +L L L+ N S+ Sbjct: 174 SYIRIADTNITTIPQGLPPSLTELHLDGNKITKVDAA-SLKGLNNLAKLGLSFNSISAVD 232 Query: 465 GDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSL------P 518 + P L +L L N L ++QV+YL++N ++++ P Sbjct: 233 NGSL-ANTPHLRELHLNNNKLVK------VPGGLADHKYIQVVYLHNNNISAIGSNDFCP 285 Query: 519 PGVFSHLTALRGLSLNSN 536 PG + + G+SL SN Sbjct: 286 PGYNTKKASYSGVSLFSN 303 Score = 103 bits (256), Expect = 3e-22, Method: Composition-based stats. Identities = 49/236 (20%), Positives = 96/236 (40%), Gaps = 17/236 (7%) Query: 341 LNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIH 400 L+L N + E+ +F L + + L N I+ I F L KL+ L L N L + Sbjct: 57 LDLQNNKITEIKDGDFKNLKNLHTLILINNKISKISPGAFAPLVKLERLYLSKNQLKELP 116 Query: 401 F--IPSIPDIFLSGNKLVTLPKINLTANL----IHLSENRLENLDIL-YFLLRVPHLQIL 453 ++ ++ + N++ + K + L N L++ I + L + Sbjct: 117 EKMPKTLQELRVHENEITKVRKSVFNGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYI 176 Query: 454 ILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNY 513 + ++ PSL +L L N + L +GL++L L L+ N Sbjct: 177 RIADTNITTIPQ----GLPPSLTELHLDGNKITKVDAASL-----KGLNNLAKLGLSFNS 227 Query: 514 LNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPAN-LEILDISRNQLLAPNPDVF 568 ++++ G ++ LR L LN+N+L + ++++ + N + A + F Sbjct: 228 ISAVDNGSLANTPHLRELHLNNNKLVKVPGGLADHKYIQVVYLHNNNISAIGSNDF 283 Score = 91.0 bits (224), Expect = 2e-18, Method: Composition-based stats. Identities = 57/293 (19%), Positives = 107/293 (36%), Gaps = 33/293 (11%) Query: 90 AFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTR 149 FR +LR++ + + D L L +++ +KDG F+NLK L Sbjct: 26 PFRCQCHLRVVQCSDLGLEKVPKDL---PPDTALLDLQNNKITE--IKDGDFKNLKNLHT 80 Query: 150 LDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLY 209 L L N+I + +F L L+ + S NQ+ + E KTL + N + Sbjct: 81 LILINNKISKIS-PGAFAPLVKLERLYLSKNQLKELPEKM-----PKTLQELRVHENEIT 134 Query: 210 SRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGF 269 + ++++ N S+ I + +I A Sbjct: 135 KVRKSVFNGLNQMI------VVELGTNPLK-------SSGIENGAFQGMKKLSYIRIADT 181 Query: 270 GFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIAD 329 I GL S + L L + +++ + L +L L L++N I+ + + Sbjct: 182 NITTIPQ-------GLPPS-LTELHLDGNKITKVDAASLKGLNNLAKLGLSFNSISAVDN 233 Query: 330 EAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKF 382 + +L+ L+L+ N L ++ + + L N+I+ I F Sbjct: 234 GSLANTPHLRELHLNNNKLVKVPGGLADH-KYIQVVYLHNNNISAIGSNDFCP 285 Score = 84.5 bits (207), Expect = 2e-16, Method: Composition-based stats. Identities = 47/234 (20%), Positives = 79/234 (33%), Gaps = 27/234 (11%) Query: 24 CSFDGRIAFYRFCNLTQVPQVLNT-TERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYT 82 C R+ L +VP+ L T L L N I + F L+ L L L + Sbjct: 29 CQCHLRVVQCSDLGLEKVPKDLPPDTALLDLQNNKITEIKDGDFKNLKNLHTLILINN-K 87 Query: 83 PLTIDKEAFRNLPNLRILDLGSSKIYFLHP---------------------DAFQGLFHL 121 I AF L L L L +++ L F GL + Sbjct: 88 ISKISPGAFAPLVKLERLYLSKNQLKELPEKMPKTLQELRVHENEITKVRKSVFNGLNQM 147 Query: 122 FELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQ 181 + L L + +++G F+ +K L+ + ++ I ++ G SL + N+ Sbjct: 148 IVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQ----GLPPSLTELHLDGNK 203 Query: 182 IFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSG 235 I V L+ L S + S S+ + +++ V G Sbjct: 204 ITKVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLNNNKLVKVPG 257 Score = 64.8 bits (156), Expect = 2e-10, Method: Composition-based stats. Identities = 45/204 (22%), Positives = 76/204 (37%), Gaps = 16/204 (7%) Query: 449 HLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLY 508 HL+++ + D P L L N + TE+ F+ L +L L Sbjct: 32 HLRVVQCSDLGLEKVPKDLPPDTA----LLDLQNNKI-----TEIKDGDFKNLKNLHTLI 82 Query: 509 LNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVF 568 L +N ++ + PG F+ L L L L+ N+L L +P L+ L + N++ VF Sbjct: 83 LINNKISKISPGAFAPLVKLERLYLSKNQLKELP-EKMPKTLQELRVHENEITKVRKSVF 141 Query: 569 VSLS---VLDITHNKFICE-CELSTFINWLNHTNVTIAGPP-ADIYCVYPDSFSGVSLFS 623 L+ V+++ N E F + + IA I P S + + L Sbjct: 142 NGLNQMIVVELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITTIPQGLPPSLTELHLDG 201 Query: 624 LSTEGCDEEEVLKSLKFSLFIVCT 647 + LK L + + Sbjct: 202 NKITK-VDAASLKGLNNLAKLGLS 224 Score = 45.9 bits (107), Expect = 8e-05, Method: Composition-based stats. Identities = 27/125 (21%), Positives = 40/125 (32%), Gaps = 29/125 (23%) Query: 37 NLTQVPQ-VLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLP 95 N+T +PQ + + L L N I V A+S L L L L Sbjct: 182 NITTIPQGLPPSLTELHLDGNKITKVDAASLKGLNNLAKLGLSF---------------- 225 Query: 96 NLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKN 155 + I + + HL EL L L G + K + + L N Sbjct: 226 ---------NSISAVDNGSLANTPHLRELHLNNNKLVKVP---GGLADHKYIQVVYLHNN 273 Query: 156 QIRSL 160 I ++ Sbjct: 274 NISAI 278 >5YQ5-A nrPDB Length = 430 Score = 134 bits (337), Expect = 2e-31, Method: Composition-based stats. Identities = 72/289 (24%), Positives = 111/289 (38%), Gaps = 39/289 (13%) Query: 247 SNAISKSQAFSLILAHHIMGAGFGFHNIKDP--DQNTFAGLARSSVRHLDLSHGFVFSLN 304 N I A S I A H+ + IK D FA L ++ L L H + Sbjct: 98 FNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLP--NLLQLHLEHNNLEEFP 155 Query: 305 SRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLG--------------- 349 F K L+ L L YN+I+K+ A GL NL +L+L YN L Sbjct: 156 ---FPLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDKIFAKMEKL 212 Query: 350 ---ELYSSNFYGLP-----KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALT---- 397 L S+ +P + Y+ L+ N I+ I ++ F L KL TL + N L Sbjct: 213 MQLNLCSNRLESMPPGLPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKLQDIPY 272 Query: 398 TIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFL-----LRVPHLQI 452 I +P+I ++ + NKL I ++L N +E +++ L HL Sbjct: 273 NIFNLPNIVELSVGHNKLKQAFYIPRNLEHLYLQNNEIEKMNLTVMCPSIDPLHYHHLTY 332 Query: 453 LILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGL 501 + ++QN+ P + ++ GE +L VF Sbjct: 333 IRVDQNKLKEPISSYIFFCFPHIHTIYYGEQRSTNGQTIQLKTQVFRRF 381 Score = 121 bits (302), Expect = 2e-27, Method: Composition-based stats. Identities = 56/239 (23%), Positives = 94/239 (39%), Gaps = 32/239 (13%) Query: 33 YRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQ-YTPLTIDKEAF 91 L +P + ++L L FN I VTA+SF L+ + L ID F Sbjct: 76 CDNRKLKTIPNIPMHIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVF 135 Query: 92 RNLPNL---------------------RILDLGSSKIYFLHPDAFQGLFHLFELRLYFCG 130 LPNL L LG ++I L +A GL +L L L + Sbjct: 136 AKLPNLLQLHLEHNNLEEFPFPLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNY 195 Query: 131 LSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHEL 190 L D++LKD F ++ L +L+L N++ S+ G +SL + +N I + E Sbjct: 196 LHDSLLKDKIFAKMEKLMQLNLCSNRLESMPP----GLPSSLMYLSLENNSISSIPEKYF 251 Query: 191 EPLQGKTLSFFSLAANSLY----SRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGN 245 + L L ++ N L + ++ ++ N + + + N + + N Sbjct: 252 DKL--PKLHTLRMSHNKLQDIPYNIFNLPNIVELSVGHNKLKQAFYIPRNLEHLYLQNN 308 Score = 103 bits (256), Expect = 3e-22, Method: Composition-based stats. Identities = 63/269 (23%), Positives = 96/269 (35%), Gaps = 33/269 (12%) Query: 287 RSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKI--NKIADEAFYGLDNLQVLNLS 344 ++ L L + ++ + F LK +NL++NKI KI F L NL L+L Sbjct: 88 PMHIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHLE 147 Query: 345 YNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPS 404 +N L E F + + L N I+ +Q L L LDL N L Sbjct: 148 HNNLEEFP---FPLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDK 204 Query: 405 IPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCS 464 I K+ L ++NL +N + L L L L N SS Sbjct: 205 IF------AKMEKLMQLNLCSNRLESMPPGLP-----------SSLMYLSLENNSISSIP 247 Query: 465 GDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSH 524 + P L L + N LQ L ++ L + HN L F Sbjct: 248 EKYF-DKLPKLHTLRMSHNKLQDIPYNIF------NLPNIVELSVGHNKLKQ----AFYI 296 Query: 525 LTALRGLSLNSNRLTVLSHNDLPANLEIL 553 L L L +N + ++ + +++ L Sbjct: 297 PRNLEHLYLQNNEIEKMNLTVMCPSIDPL 325 Score = 97.5 bits (241), Expect = 2e-20, Method: Composition-based stats. Identities = 64/288 (22%), Positives = 117/288 (40%), Gaps = 40/288 (13%) Query: 305 SRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGE--LYSSNFYGLPKV 362 + ++ L L +N+I + +F +L+ +NLS+N + + F LP + Sbjct: 82 KTIPNIPMHIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNL 141 Query: 363 AYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKIN 422 + L+ N++ ++ F + L+ L L N ++ + + LV L ++ Sbjct: 142 LQLHLEHNNL---EEFPFPLPKSLERLLLGYNEISKLQTNA--------MDGLVNLTMLD 190 Query: 423 LTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGE 482 L N +H S L ++ L L L NR S P SL L L Sbjct: 191 LCYNYLHDS------LLKDKIFAKMEKLMQLNLCSNRLESMP----PGLPSSLMYLSLEN 240 Query: 483 NMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLS 542 N + + + F+ L L L ++HN L +P +F+ L + LS+ N+L Sbjct: 241 NSI-----SSIPEKYFDKLPKLHTLRMSHNKLQDIPYNIFN-LPNIVELSVGHNKLK--Q 292 Query: 543 HNDLPANLEILDISRNQLL---------APNPDVFVSLSVLDITHNKF 581 +P NLE L + N++ + +P + L+ + + NK Sbjct: 293 AFYIPRNLEHLYLQNNEIEKMNLTVMCPSIDPLHYHHLTYIRVDQNKL 340 Score = 92.9 bits (229), Expect = 5e-19, Method: Composition-based stats. Identities = 56/274 (20%), Positives = 100/274 (36%), Gaps = 37/274 (13%) Query: 337 NLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHI--AIIQDQTFKFLEKLQTLDLRDN 394 ++Q L L +N + + +++F + I+L N I I F L L L L N Sbjct: 90 HIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHLEHN 149 Query: 395 ALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILI 454 L F + + + L N + L + + +L +L Sbjct: 150 NLEEFPF------------------PLPKSLERLLLGYNEISKLQ-TNAMDGLVNLTMLD 190 Query: 455 LNQNRF-SSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNY 513 L N S D+ ++ L QL L N L+ S L L L +N Sbjct: 191 LCYNYLHDSLLKDKIFAKMEKLMQLNLCSNRLESMPPGL--------PSSLMYLSLENNS 242 Query: 514 LNSLPPGVFSHLTALRGLSLNSNRLTVLSHN-DLPANLEILDISRNQLLAPNPDVFVSLS 572 ++S+P F L L L ++ N+L + +N N+ L + N+L + +L Sbjct: 243 ISSIPEKYFDKLPKLHTLRMSHNKLQDIPYNIFNLPNIVELSVGHNKLKQ-AFYIPRNLE 301 Query: 573 VLDITHN-----KFICECELSTFINWLNHTNVTI 601 L + +N C +++ + T + + Sbjct: 302 HLYLQNNEIEKMNLTVMCPSIDPLHYHHLTYIRV 335 Score = 76.4 bits (186), Expect = 5e-14, Method: Composition-based stats. Identities = 50/197 (25%), Positives = 87/197 (44%), Gaps = 24/197 (12%) Query: 407 DIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGD 466 ++ KL T+P I + ++L N +E + + HL+ + L+ N+ S D Sbjct: 73 SMYCDNRKLKTIPNIPMHIQQLYLQFNEIEAV-TANSFINATHLKEINLSHNKIKSQKID 131 Query: 467 Q-TPSENPSLEQLFLGENMLQL----------------AWETELCWDVFEGLSHLQVLYL 509 ++ P+L QL L N L+ ++L + +GL +L +L L Sbjct: 132 YGVFAKLPNLLQLHLEHNNLEEFPFPLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDL 191 Query: 510 NHNYLNS--LPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDV 567 +NYL+ L +F+ + L L+L SNRL + LP++L L + N + + Sbjct: 192 CYNYLHDSLLKDKIFAKMEKLMQLNLCSNRLESMPPG-LPSSLMYLSLENNSISSIPEKY 250 Query: 568 FVSLSVLD---ITHNKF 581 F L L ++HNK Sbjct: 251 FDKLPKLHTLRMSHNKL 267 Score = 67.9 bits (164), Expect = 2e-11, Method: Composition-based stats. Identities = 45/220 (20%), Positives = 80/220 (36%), Gaps = 35/220 (15%) Query: 34 RFCNLTQVPQVLN-TTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYT---------- 82 NL + P L + ERLLL +N I + ++ L L +L+L Y Sbjct: 147 EHNNLEEFPFPLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDKIF 206 Query: 83 -------PLTIDKEAFRNLP-----NLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCG 130 L + ++P +L L L ++ I + F L L LR+ Sbjct: 207 AKMEKLMQLNLCSNRLESMPPGLPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNK 266 Query: 131 LSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHEL 190 L D F NL + L + N+++ +F +L+ + +N+I + + Sbjct: 267 LQDIPY--NIF-NLPNIVELSVGHNKLK-----QAFYIPRNLEHLYLQNNEIEKMNLTVM 318 Query: 191 ----EPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNM 226 +PL L++ + N L +S C + Sbjct: 319 CPSIDPLHYHHLTYIRVDQNKLKEPISSYIFFCFPHIHTI 358 >5MX0-A nrPDB Length = 362 Score = 129 bits (325), Expect = 4e-30, Method: Composition-based stats. Identities = 59/229 (25%), Positives = 94/229 (41%), Gaps = 28/229 (12%) Query: 290 VRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLG 349 + L L H + + + L+ L+L +N+I+++ + A GL+NL L L +N + Sbjct: 143 LERLYLDHNNLTRMPGPLPR---SLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQ 199 Query: 350 ELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIF 409 E+ SS GL + +DL NH+ + D LE+ L + N + T +PD + Sbjct: 200 EVGSS-MRGLRSLILLDLSYNHLRKVPDGLPSALEQ---LYMEHNNVYT------VPDSY 249 Query: 410 LSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTP 469 G + LS N L N + L L L+ N+ P Sbjct: 250 FRGAP---------KLLYVRLSHNSLTNNGLASNTFNSSSLLELDLSYNQLQKI-----P 295 Query: 470 SENPSLEQLFLGENMLQLAWETELCWDV-FEGLSHLQVLYLNHNYLNSL 517 N +LE L+L N + + C V S LQVL L+ N + Sbjct: 296 PVNTNLENLYLQGNRINEFSISSFCTVVDVVNFSKLQVLRLDGNEIKRS 344 Score = 100 bits (249), Expect = 3e-21, Method: Composition-based stats. Identities = 56/287 (19%), Positives = 105/287 (36%), Gaps = 42/287 (14%) Query: 285 LARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKI--NKIADEAFYGLDNLQVLN 342 S ++++ + + S+ VF+ L + L N+I +K+ + F L +L+ L Sbjct: 88 FVPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLY 147 Query: 343 LSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFI 402 L +N L + + + L N I+ + + + LE L L L+ N + + Sbjct: 148 LDHNNLTRMPGPLP---RSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQEVGS- 203 Query: 403 PSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSS 462 S L +L ++L+ N + + L L+ L + N + Sbjct: 204 --------SMRGLRSLILLDLSYNHLRKVPDGLP-----------SALEQLYMEHNNVYT 244 Query: 463 CSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVF 522 D P L + L N L ++ L L++N L +PP Sbjct: 245 VP-DSYFRGAPKLLYVRLSHNSLTNNGLASNTFNSSSLLEL----DLSYNQLQKIPP--- 296 Query: 523 SHLTALRGLSLNSNRLTVLSHNDL--------PANLEILDISRNQLL 561 T L L L NR+ S + + L++L + N++ Sbjct: 297 -VNTNLENLYLQGNRINEFSISSFCTVVDVVNFSKLQVLRLDGNEIK 342 Score = 88.7 bits (218), Expect = 1e-17, Method: Composition-based stats. Identities = 57/252 (22%), Positives = 90/252 (35%), Gaps = 35/252 (13%) Query: 336 DNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHI--AIIQDQTFKFLEKLQTLDLRD 393 ++ + N + + F + +I L N I + + F L L+ L L Sbjct: 91 SRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLYLDH 150 Query: 394 NALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQIL 453 N LT + G +L +++L N I N L + +L L Sbjct: 151 NNLTRMP-----------GPLPRSLRELHLDHNQISRVPN--------NALEGLENLTAL 191 Query: 454 ILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNY 513 L N SL L L N L+ + S L+ LY+ HN Sbjct: 192 YLQHNEIQEVGSSM--RGLRSLILLDLSYNHLRKVPDGL--------PSALEQLYMEHNN 241 Query: 514 LNSLPPGVFSHLTALRGLSLNSNRLTV---LSHNDLPANLEILDISRNQLLAPNPDVFVS 570 + ++P F L + L+ N LT S+ ++L LD+S NQL P V + Sbjct: 242 VYTVPDSYFRGAPKLLYVRLSHNSLTNNGLASNTFNSSSLLELDLSYNQLQKI-PPVNTN 300 Query: 571 LSVLDITHNKFI 582 L L + N+ Sbjct: 301 LENLYLQGNRIN 312 Score = 82.9 bits (203), Expect = 6e-16, Method: Composition-based stats. Identities = 59/287 (20%), Positives = 104/287 (36%), Gaps = 43/287 (14%) Query: 95 PNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSK 154 ++ + +++I + F L + L+ ++ + F L+ L RL L Sbjct: 91 SRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLYLDH 150 Query: 155 NQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSV 214 N + + SL+ + NQI V + LE L+ L+ L N + S Sbjct: 151 NNLTRMP----GPLPRSLRELHLDHNQISRVPNNALEGLEN--LTALYLQHNEIQEVGS- 203 Query: 215 DWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNI 274 M R+++L LD+S N G L + +N+ Sbjct: 204 ----SMRGLRSLIL--LDLSYNHLRKVPDG---------------LPSALEQLYMEHNNV 242 Query: 275 KDPDQNTFAGLARSSVRHLDLSHGFVFS--LNSRVFETLKDLKVLNLAYNKINKIADEAF 332 + F G + ++ LSH + + L S F + L++ +YN++ KI Sbjct: 243 YTVPDSYFRG--APKLLYVRLSHNSLTNNGLASNTFNSSSLLELDL-SYNQLQKIPPVN- 298 Query: 333 YGLDNLQVLNLSYNLLGELYSSNF------YGLPKVAYIDLQKNHIA 373 NL+ L L N + E S+F K+ + L N I Sbjct: 299 ---TNLENLYLQGNRINEFSISSFCTVVDVVNFSKLQVLRLDGNEIK 342 Score = 81.4 bits (199), Expect = 1e-15, Method: Composition-based stats. Identities = 59/310 (19%), Positives = 105/310 (33%), Gaps = 42/310 (13%) Query: 33 YRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLEL-GSQYTPLTIDKEAF 91 NL +P V + + + N I ++ F L + L G+Q T + ++ F Sbjct: 78 CDNRNLKYLPFVPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVF 137 Query: 92 RNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLD 151 L +L L L + + + L EL L +S + + L+ LT L Sbjct: 138 SKLRHLERLYLDHNNLTRMPGPL---PRSLRELHLDHNQISR--VPNNALEGLENLTALY 192 Query: 152 LSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSR 211 L N+I+ + S L SL +D S N + V + L L + N++Y+ Sbjct: 193 LQHNEIQ--EVGSSMRGLRSLILLDLSYNHLRKVP----DGLP-SALEQLYMEHNNVYT- 244 Query: 212 VSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGF 271 V + + + L ++ NG + + S L + Sbjct: 245 VPDSYFRGAPKLLYVRLSHNSLTNNGLASNTFNSSSLLELDLSYNQLQKIPPV------- 297 Query: 272 HNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVF------ETLKDLKVLNLAYNKIN 325 +++ +L L + + F L+VL L N+I Sbjct: 298 ---------------NTNLENLYLQGNRINEFSISSFCTVVDVVNFSKLQVLRLDGNEIK 342 Query: 326 KIADEAFYGL 335 + A A L Sbjct: 343 RSAMPADAPL 352 Score = 66.7 bits (161), Expect = 4e-11, Method: Composition-based stats. Identities = 37/176 (21%), Positives = 68/176 (38%), Gaps = 11/176 (6%) Query: 408 IFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRF-SSCSGD 466 ++ L LP + ++ N++ ++ L + L+ N+ S G Sbjct: 76 MYCDNRNLKYLPFVPSRMKYVYFQNNQITSIQ-EGVFDNATGLLWIALHGNQITSDKVGR 134 Query: 467 QTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLT 526 + S+ LE+L+L N L L+ L+L+HN ++ +P L Sbjct: 135 KVFSKLRHLERLYLDHNNLTRMPG--------PLPRSLRELHLDHNQISRVPNNALEGLE 186 Query: 527 ALRGLSLNSNRLTVLSHNDL-PANLEILDISRNQLLAPNPDVFVSLSVLDITHNKF 581 L L L N + + + +L +LD+S N L + +L L + HN Sbjct: 187 NLTALYLQHNEIQEVGSSMRGLRSLILLDLSYNHLRKVPDGLPSALEQLYMEHNNV 242 Score = 52.1 bits (123), Expect = 1e-06, Method: Composition-based stats. Identities = 32/150 (21%), Positives = 56/150 (37%), Gaps = 11/150 (7%) Query: 32 FYRFCNLTQVPQVLNT-TERLLLSFNYIRTVTASSFPFLEQLQLLELGSQY-TPLTIDKE 89 + +L +VP L + E+L + N + TV S F +L + L T + Sbjct: 215 DLSYNHLRKVPDGLPSALEQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNSLTNNGLASN 274 Query: 90 AFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKD----GYFRNLK 145 F N +L LDL +++ + P +L L L +++ + N Sbjct: 275 TF-NSSSLLELDLSYNQLQKIPPVN----TNLENLYLQGNRINEFSISSFCTVVDVVNFS 329 Query: 146 ALTRLDLSKNQIRSLYLHPSFGKLNSLKSI 175 L L L N+I+ + L S+ Sbjct: 330 KLQVLRLDGNEIKRSAMPADAPLCLRLASL 359 >2Z7X-B nrPDB Length = 520 Score = 129 bits (325), Expect = 4e-30, Method: Composition-based stats. Identities = 102/553 (18%), Positives = 185/553 (33%), Gaps = 75/553 (13%) Query: 73 QLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLS 132 +L + Y + +L LRIL + ++I +L F+ L L L L Sbjct: 24 TILNISQNY-ISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLV 82 Query: 133 DAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEP 192 L LDLS N +L + FG ++ LK + S+ Sbjct: 83 KI-----SCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTT------------ 125 Query: 193 LQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISK 252 + + + L++S + T Sbjct: 126 --------------------------HLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEG 159 Query: 253 SQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLK 312 Q F+ H + FH I D T A L S+++ + L S + + Sbjct: 160 LQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCV-LEDNKCSYFLSILAKLQT 218 Query: 313 DLKVLNLAYNKINKIADEAFYGLDNL----QVLNLSYNLLGELYSSNFYGLPKVAYIDLQ 368 + K+ NL N I +F + L V S + + +F L+ Sbjct: 219 NPKLSNLTLNNIETT-WNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGT-SLK 276 Query: 369 KNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLI 428 I + F + + I +I + +SG ++V + + + + Sbjct: 277 ALSIHQVVSDVFG---------FPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFL 327 Query: 429 HLSE-NRLENLDILYFLLRVPHLQILILNQNRFSSCSG-DQTPSENPSLEQLFLGENMLQ 486 HL N L + + L+ LIL N+ S + ++ SL+QL + +N + Sbjct: 328 HLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVS 387 Query: 487 LAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHL-TALRGLSLNSNRLTVLSHND 545 + C L L ++ N L +F L ++ L L+SN++ + Sbjct: 388 YDEKKGDCSWT----KSLLSLNMSSNILT---DTIFRCLPPRIKVLDLHSNKIKSIPKQV 440 Query: 546 LP-ANLEILDISRNQLLAPNPDVFVSLSVLD---ITHNKFICECELSTFI-NWLNHTNVT 600 + L+ L+++ NQL + +F L+ L + N + C C ++ WLN + Sbjct: 441 VKLEALQELNVASNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLSRWLNKNSQK 500 Query: 601 IAGPPADIYCVYP 613 G P Sbjct: 501 EQGSAKCSGSGKP 513 Score = 76.0 bits (185), Expect = 7e-14, Method: Composition-based stats. Identities = 88/462 (19%), Positives = 154/462 (33%), Gaps = 81/462 (17%) Query: 44 VLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLG 103 L+ L++S N I+ + S F F ++L+ L+L + K + NL+ LDL Sbjct: 43 SLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHN----KLVKISCHPTVNLKHLDLS 98 Query: 104 SSKIYFLH-PDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQ------ 156 + L F + L L L L + + N+ + L L + Sbjct: 99 FNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKV-LLVLGETYGEKEDP 157 Query: 157 -----IRSLYLHPSFGKLNSLKS-----------IDFSS-----------NQIFLVCEHE 189 + LH F ++ S+ + ++ + + Sbjct: 158 EGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQ 217 Query: 190 LEP-LQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEI---LDVSGNGWTVDITGN 245 P L TL+ NS + + W + F +++ LD ++ Sbjct: 218 TNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKA 277 Query: 246 FSNAISKSQAFSLILAHHIMG-AGFGFHNIKDPDQNTFAGLARSSVR---HLDLSHGFVF 301 S S F ++ + N L S + HLD S+ + Sbjct: 278 LSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLT 337 Query: 302 SLNSRVFETLKDLKVLNLAYNKINKIA--DEAFYGLDNLQVLNLSYNLL----GELYSSN 355 L +L+ L L N++ +++ E + +LQ L++S N + + S Sbjct: 338 DTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSW 397 Query: 356 FYGLPKV-------------------AYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNAL 396 L + +DL N I I Q K LE LQ L++ N L Sbjct: 398 TKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVK-LEALQELNVASNQL 456 Query: 397 TTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENL 438 ++ I D +L +L KI L N S R++ L Sbjct: 457 KSVPD--GIFD------RLTSLQKIWLHTNPWDCSCPRIDYL 490 Score = 57.9 bits (138), Expect = 2e-08, Method: Composition-based stats. Identities = 70/408 (17%), Positives = 128/408 (31%), Gaps = 71/408 (17%) Query: 32 FYRFCNLTQVPQVLN-TTERLLLSFNYIRTVT-ASSFPFLEQLQLLELGSQYT------- 82 L ++ + L LSFN + F + QL+ L L + + Sbjct: 75 DLSHNKLVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLP 134 Query: 83 -----------------PLTIDKEAFR--NLPNLRILDLGSSKIYFLHPDAFQGLFHLF- 122 D E + N +L I+ + + +F+ + + + +L Sbjct: 135 IAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLEL 194 Query: 123 -----ELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDF 177 L C ++L + L+ L L+ + + F Sbjct: 195 SNIKCVLEDNKCSYFLSILAK--LQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYF 252 Query: 178 SSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRV-SVDWGKCMNPFRNMVLEILDVSG- 235 S + + L + + S +L+ + + S V F NM ++ VSG Sbjct: 253 SISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGT 312 Query: 236 --------NGWTVDITGNFSNAISKSQAFS-LILAHHIMGAGFGFHNIKDPDQNTFAGLA 286 + + + +FSN + F + + +K+ + Sbjct: 313 RMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQ 372 Query: 287 RSSVRHLDLSHGFVFS----------------------LNSRVFETLK-DLKVLNLAYNK 323 S++ LD+S V L +F L +KVL+L NK Sbjct: 373 MKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNK 432 Query: 324 INKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNH 371 I I + L+ LQ LN++ N L + F L + I L N Sbjct: 433 IKSIP-KQVVKLEALQELNVASNQLKSVPDGIFDRLTSLQKIWLHTNP 479 >2XOT-A nrPDB Length = 361 Score = 126 bits (315), Expect = 6e-29, Method: Composition-based stats. Identities = 59/195 (30%), Positives = 82/195 (42%), Gaps = 7/195 (3%) Query: 18 VFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERL-LLSFNYIRTVTASSFP-FLEQLQLL 75 V +C I L VPQ L + L LS N + + A P L L L Sbjct: 10 VSCPANCLCASNILSCSKQQLPNVPQSLPSYTALLDLSHNNLSRLRAEWTPTRLTNLHSL 69 Query: 76 ELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAV 135 L + I EAF +PNLR LDL S+ ++ L F L L L LY + V Sbjct: 70 LLSHNHLNF-ISSEAFVPVPNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHI--VV 126 Query: 136 LKDGYFRNLKALTRLDLSKNQIRS--LYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPL 193 + F ++ L +L LS+NQI + L KL L +D SSN++ + +L+ L Sbjct: 127 VDRNAFEDMAQLQKLYLSQNQISRFPVELIKDGNKLPKLMLLDLSSNKLKKLPLTDLQKL 186 Query: 194 QGKTLSFFSLAANSL 208 + L N L Sbjct: 187 PAWVKNGLYLHNNPL 201 Score = 116 bits (290), Expect = 4e-26, Method: Composition-based stats. Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%) Query: 293 LDLSHGFVFSLNSRV-FETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGEL 351 LDLSH + L + L +L L L++N +N I+ EAF + NL+ L+LS N L L Sbjct: 44 LDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHLHTL 103 Query: 352 YSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI--------HFIP 403 F L + + L NHI ++ F+ + +LQ L L N ++ + +P Sbjct: 104 DEFLFSDLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNQISRFPVELIKDGNKLP 163 Query: 404 SIPDIFLSGNKLVTLPKINLT------ANLIHLSENRLE 436 + + LS NKL LP +L N ++L N LE Sbjct: 164 KLMLLDLSSNKLKKLPLTDLQKLPAWVKNGLYLHNNPLE 202 Score = 91.8 bits (226), Expect = 1e-18, Method: Composition-based stats. Identities = 56/244 (22%), Positives = 102/244 (41%), Gaps = 20/244 (8%) Query: 400 HFIPSIPDIFLSGNKLVTLPK-INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQN 458 + + + + S +L +P+ + L+ LS N L L + R+ +L L+L+ N Sbjct: 15 NCLCASNILSCSKQQLPNVPQSLPSYTALLDLSHNNLSRLRAEWTPTRLTNLHSLLLSHN 74 Query: 459 RFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLP 518 + S + P+L L L N L E +F L L+VL L +N++ + Sbjct: 75 HLNFISSEAFV-PVPNLRYLDLSSNHLHTLDE-----FLFSDLQALEVLLLYNNHIVVVD 128 Query: 519 PGVFSHLTALRGLSLNSNRLTVLSHNDLPAN-----LEILDISRNQLLAPNPDVFVSL-- 571 F + L+ L L+ N+++ + L +LD+S N+L L Sbjct: 129 RNAFEDMAQLQKLYLSQNQISRFPVELIKDGNKLPKLMLLDLSSNKLKKLPLTDLQKLPA 188 Query: 572 ---SVLDITHNKFICECEL-STFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTE 627 + L + +N C+C+L F +W ++ D+YC++ ++FSL Sbjct: 189 WVKNGLYLHNNPLECDCKLYQLFSHWQYRQLSSVMDFQEDLYCMHSKKLH--NIFSLDFF 246 Query: 628 GCDE 631 C E Sbjct: 247 NCSE 250 Score = 48.6 bits (114), Expect = 1e-05, Method: Composition-based stats. Identities = 42/217 (19%), Positives = 72/217 (33%), Gaps = 53/217 (24%) Query: 150 LDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLY 209 LDLS N + L + +L +L S+ S N + + P L + L++N L+ Sbjct: 44 LDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHLNFISSEAFVP--VPNLRYLDLSSNHLH 101 Query: 210 SRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGF 269 ++ F L+ L+V Sbjct: 102 ---------TLDEFLFSDLQALEV---------------------------------LLL 119 Query: 270 GFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFET---LKDLKVLNLAYNKINK 326 ++I D+N F +A+ ++ L LS + + + L L +L+L+ NK+ K Sbjct: 120 YNNHIVVVDRNAFEDMAQ--LQKLYLSQNQISRFPVELIKDGNKLPKLMLLDLSSNKLKK 177 Query: 327 IADEAFYGLDNLQV--LNLSYNLLGELYSSNFYGLPK 361 + L L L N L Y L Sbjct: 178 LPLTDLQKLPAWVKNGLYLHNNPLE--CDCKLYQLFS 212 >2JS7-A nrPDB Length = 160 Score = 123 bits (309), Expect = 2e-28, Method: Composition-based stats. Identities = 38/163 (23%), Positives = 67/163 (41%), Gaps = 17/163 (10%) Query: 681 DHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENR 740 D P G P+ ++DA++C+ D +VQ + + T Y R LC +RD +PG Sbjct: 7 DDPLGHMPE--RFDAFICYCPSDIQFVQEMIRQLEQTNY----RLKLCVSDRDVLPGTCV 60 Query: 741 IANIQDAIWNS-RKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQ 799 + + I R++V +VS +L+ C +A LS ++ + Sbjct: 61 WSIASELIEKRCRRMVVVVSDDYLQSKECDFQTKFALS--LSPGAHQKRLI---PIKYKA 115 Query: 800 LMK-HQSIRGFVQKQQYLRWPEDFQDVGWFLHKLSQQILKKEK 841 + K SI F+ Y P WF +L++ + + Sbjct: 116 MKKEFPSILRFITVCDYTN-PCTKS---WFWTRLAKALSLPLE 154 >6HLU-A nrPDB Length = 974 Score = 122 bits (307), Expect = 4e-28, Method: Composition-based stats. Identities = 68/301 (22%), Positives = 122/301 (40%), Gaps = 41/301 (13%) Query: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348 S+ L LS + + +LK L L+L+ N I+ IA L +L L+LS N + Sbjct: 158 SLTELQLSSNQITDI--APLASLKSLTELSLSGNNISDIAP--LESLKSLTELSLSSNQI 213 Query: 349 GELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDI 408 ++ L + + L N I+ + L+ L L L N ++ I + Sbjct: 214 TDIAP--LASLKSLTELSLSSNQIS--DIAPLESLKSLTELQLSRNQISDIAPL------ 263 Query: 409 FLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQT 468 L +L ++ L++N I L + L L L++N+ S + ++ Sbjct: 264 ----ESLKSLTELQLSSNQITDI----------APLASLKSLTELQLSRNQISDIAPLES 309 Query: 469 PSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTAL 528 + SL +L+L N + L+ L L L+ N + + P + L +L Sbjct: 310 LN---SLSKLWLNGNQITDIAP-------LASLNSLTELELSSNQITDIAP--LASLKSL 357 Query: 529 RGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNP-DVFVSLSVLDITHNKFICECEL 587 L L+SN+++ ++ +L L +S NQ+ +P SL+ D+ N E Sbjct: 358 STLWLSSNQISDIAPLASLESLSELSLSSNQISDISPLASLNSLTGFDVRRNPIKRLPET 417 Query: 588 S 588 Sbjct: 418 I 418 Score = 106 bits (263), Expect = 6e-23, Method: Composition-based stats. Identities = 81/390 (20%), Positives = 137/390 (35%), Gaps = 53/390 (13%) Query: 105 SKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHP 164 ++I + P L L L L ++D +L +L+ L L N+I + Sbjct: 101 NQITDISP--LASLNSLSMLWLDRNQITDIA----PLASLNSLSMLWLFGNKISDIAPLE 154 Query: 165 SFGKLNSLKSIDFSSNQIFLVCEHELEPLQ-GKTLSFFSLAANSLYSRVSVDWGKCMNPF 223 L SL + SSNQI ++ PL K+L+ SL+ N++ ++ K + Sbjct: 155 ---SLKSLTELQLSSNQIT-----DIAPLASLKSLTELSLSGNNISDIAPLESLKSLTEL 206 Query: 224 RNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFA 283 +I D++ LA + + D Sbjct: 207 SLSSNQITDIAP------------------------LASLKSLTELSLSSNQISDIAPLE 242 Query: 284 GLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNL 343 L S+ L LS + + E+LK L L L+ N+I IA L +L L L Sbjct: 243 SLK--SLTELQLSRNQISDI--APLESLKSLTELQLSSNQITDIAP--LASLKSLTELQL 296 Query: 344 SYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIP 403 S N + ++ L ++ + L N I L L L+L N +T I + Sbjct: 297 SRNQISDIAP--LESLNSLSKLWLNGNQIT--DIAPLASLNSLTELELSSNQITDIAPLA 352 Query: 404 SIPDIF---LSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRF 460 S+ + LS N++ + + +L LS + + DI L + L + +N Sbjct: 353 SLKSLSTLWLSSNQISDIAPLASLESLSELSLSSNQISDIS-PLASLNSLTGFDVRRNPI 411 Query: 461 SSCSGDQTPSENPSLEQLFLGENMLQLAWE 490 T + L F + Sbjct: 412 KRLPETITGFDMEILWNDFSSSGFITFFDN 441 Score = 94.5 bits (233), Expect = 2e-19, Method: Composition-based stats. Identities = 85/374 (22%), Positives = 143/374 (38%), Gaps = 31/374 (8%) Query: 153 SKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQ-GKTLSFFSLAANSLYSR 211 S NQI + LNSL + NQI ++ PL +LS L N + Sbjct: 99 SSNQITDISP---LASLNSLSMLWLDRNQIT-----DIAPLASLNSLSMLWLFGNKISDI 150 Query: 212 VSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGF 271 ++ K + + +I D++ +T + + S L + Sbjct: 151 APLESLKSLTELQLSSNQITDIAPLASLKSLTELSLSGNNISDIAPLESLKSLTELSLSS 210 Query: 272 HNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEA 331 + I D A L S+ L LS + + E+LK L L L+ N+I+ IA Sbjct: 211 NQI--TDIAPLASLK--SLTELSLSSNQISDI--APLESLKSLTELQLSRNQISDIAP-- 262 Query: 332 FYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDL 391 L +L L LS N + ++ L + + L +N I+ + L L L L Sbjct: 263 LESLKSLTELQLSSNQITDIAP--LASLKSLTELQLSRNQIS--DIAPLESLNSLSKLWL 318 Query: 392 RDNALTTI---HFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVP 448 N +T I + S+ ++ LS N++ + + +L L + + DI L + Sbjct: 319 NGNQITDIAPLASLNSLTELELSSNQITDIAPLASLKSLSTLWLSSNQISDIA-PLASLE 377 Query: 449 HLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWD---VFEGLSHLQ 505 L L L+ N+ S S + + SL + N ++ ET +D ++ S Sbjct: 378 SLSELSLSSNQISDISPLASLN---SLTGFDVRRNPIKRLPETITGFDMEILWNDFSSSG 434 Query: 506 VLYLNHNYLNSLPP 519 + N L S PP Sbjct: 435 FITFFDNPLESPPP 448 Score = 94.1 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 80/361 (22%), Positives = 132/361 (36%), Gaps = 52/361 (14%) Query: 44 VLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLG 103 LN+ L L N I + L+ L L+L S D +L +L L L Sbjct: 133 SLNSLSMLWLFGNKISDIAP--LESLKSLTELQLSSNQIT---DIAPLASLKSLTELSLS 187 Query: 104 SSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLH 163 + I + P + L L EL L ++D +LK+LT L LS NQI + Sbjct: 188 GNNISDIAP--LESLKSLTELSLSSNQITDIA----PLASLKSLTELSLSSNQISDIAPL 241 Query: 164 PSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPF 223 L SL + S NQI + LE L K+L+ L++N + + K + Sbjct: 242 E---SLKSLTELQLSRNQISDIAP--LESL--KSLTELQLSSNQITDIAPLASLKSLTEL 294 Query: 224 RNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFA 283 + +I D++ ++ + N + L + Sbjct: 295 QLSRNQISDIAPLESLNSLSKLWLNGNQITDIAPLASLN--------------------- 333 Query: 284 GLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNL 343 S+ L+LS + + +LK L L L+ N+I+ IA A + L Sbjct: 334 -----SLTELELSSNQITDI--APLASLKSLSTLWLSSNQISDIAPLASLESLSELS--L 384 Query: 344 SYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFK-FLEKLQTLDLRDNALTTIHFI 402 S N + ++ S L + D+++N I + + +E L D + T Sbjct: 385 SSNQISDI--SPLASLNSLTGFDVRRNPIKRLPETITGFDMEILWN-DFSSSGFITFFDN 441 Query: 403 P 403 P Sbjct: 442 P 442 Score = 71.7 bits (174), Expect = 1e-12, Method: Composition-based stats. Identities = 50/234 (21%), Positives = 94/234 (40%), Gaps = 20/234 (8%) Query: 413 NKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSEN 472 N++ + + +L L +R + DI L + L +L L N+ S Sbjct: 101 NQITDISPLASLNSLSMLWLDRNQITDIAP-LASLNSLSMLWLFGNKISDI---APLESL 156 Query: 473 PSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLS 532 SL +L L N + L L L L+ N ++ + P L +L LS Sbjct: 157 KSLTELQLSSNQITDIAP-------LASLKSLTELSLSGNNISDIAP--LESLKSLTELS 207 Query: 533 LNSNRLTVLSHNDLPANLEILDISRNQLLAPNP-DVFVSLSVLDITHNKFICECELSTFI 591 L+SN++T ++ +L L +S NQ+ P + SL+ L ++ N+ +++ Sbjct: 208 LSSNQITDIAPLASLKSLTELSLSSNQISDIAPLESLKSLTELQLSRNQIS---DIAPLE 264 Query: 592 NWLNHTNVTIAGPPADIYCVYP-DSFSGVSLFSLSTEGCDEEEVLKSLKFSLFI 644 + + T + ++ I + P S ++ LS + L+SL + Sbjct: 265 SLKSLTELQLS--SNQITDIAPLASLKSLTELQLSRNQISDIAPLESLNSLSKL 316 Score = 41.7 bits (96), Expect = 0.002, Method: Composition-based stats. Identities = 29/119 (24%), Positives = 46/119 (38%), Gaps = 11/119 (9%) Query: 43 QVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDL 102 + LN+ +L L+ N I + L L LEL S D +L +L L L Sbjct: 308 ESLNSLSKLWLNGNQITDIAP--LASLNSLTELELSSNQIT---DIAPLASLKSLSTLWL 362 Query: 103 GSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLY 161 S++I + P A S+ + +L +LT D+ +N I+ L Sbjct: 363 SSNQISDIAPLASLESLS------ELSLSSNQISDISPLASLNSLTGFDVRRNPIKRLP 415 >3A79-B nrPDB Length = 562 Score = 122 bits (305), Expect = 8e-28, Method: Composition-based stats. Identities = 103/515 (20%), Positives = 186/515 (36%), Gaps = 54/515 (10%) Query: 32 FYRFCNLTQVPQVLNT-TERLLLSFNYIRTVTASSFPFLEQLQLLELGSQ-YTPLTIDKE 89 Y NLT VP+ L T+ L LS N I + FL +L++L L L Sbjct: 37 DYSNRNLTHVPKDLPPRTKALSLSQNSISELRMPDISFLSELRVLRLSHNRIRSLDFHVF 96 Query: 90 AFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTR 149 F +L LD+ +++ + L L L F + F NL LT Sbjct: 97 LFNQ--DLEYLDVSHNRLQNISCCPMA---SLRHLDLSFNDFDVLPV-CKEFGNLTKLTF 150 Query: 150 LDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLY 209 L LS + R L L P S +D S I L+ + T+ NSL Sbjct: 151 LGLSAAKFRQLDLLPVAHLHLSCILLDLVSYHIKGGETESLQ-IPNTTVLHLVFHPNSL- 208 Query: 210 SRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGF 269 SV +N ++ L + ++ +T F + +++ + HI Sbjct: 209 --FSVQVNMSVNALGHLQLSNIKLNDENCQRLMT--FLSELTRGPTLLNVTLQHIETT-- 262 Query: 270 GFHNIKDPDQNTFAGLARSSVRHLDLSHGFVF-SLNSRVFETL-KDLKVLNLAY--NKIN 325 F V +L++ + + ++ F LK L + + N++ Sbjct: 263 -----WKCSVKLFQFFWPRPVEYLNIYNLTITERIDREEFTYSETALKSLMIEHVKNQVF 317 Query: 326 KIADEAFYGL---DNLQVLNLSYN-LLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFK 381 + EA Y + N+++L++S + + + +++ +N + D F+ Sbjct: 318 LFSKEALYSVFAEMNIKMLSISDTPFIHMVCPPSPSSF---TFLNFTQN---VFTDSVFQ 371 Query: 382 FLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDIL 441 L+ L + + + + + L + +L ++++ N L + Sbjct: 372 GCSTLKRL---QTLILQRNGLKNFFKVALMTKNMSSLETLDVSLN-------SLNSHAYD 421 Query: 442 YFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGL 501 + +L L+ N + P P ++ L L N + L Sbjct: 422 RTCAWAESILVLNLSSNMLTGSVFRCLP---PKVKVLDLHNNRIMSI------PKDVTHL 472 Query: 502 SHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSN 536 LQ L + N L S+P GVF LT+L+ + L+ N Sbjct: 473 QALQELNVASNQLKSVPDGVFDRLTSLQYIWLHDN 507 Score = 84.5 bits (207), Expect = 2e-16, Method: Composition-based stats. Identities = 96/547 (17%), Positives = 182/547 (33%), Gaps = 94/547 (17%) Query: 95 PNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSK 154 P + L L + I L L L LRL + L F + L LD+S Sbjct: 52 PRTKALSLSQNSISELRMPDISFLSELRVLRLSHNRIRS--LDFHVFLFNQDLEYLDVSH 109 Query: 155 NQIRSLYLHPSFGKLNSLKSIDFSSNQIFLV-CEHELEPLQGKTLSFFSLAANSLYSRVS 213 N+++++ P + SL+ +D S N ++ E L L+F L+A Sbjct: 110 NRLQNISCCP----MASLRHLDLSFNDFDVLPVCKEFGNLT--KLTFLGLSAAK------ 157 Query: 214 VDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHN 273 + + L +S + Q + + H + F Sbjct: 158 ------FRQLDLLPVAHLHLSCILLDLVSYHIKGGETESLQIPNTTVLHLVFHPNSLFSV 211 Query: 274 IKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFY 333 + N L S+++ L+ L + + E + +LN+ I + Sbjct: 212 QVNMSVNALGHLQLSNIK---LNDENCQRLMTFLSELTRGPTLLNVTLQHIETT-WKCSV 267 Query: 334 GLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHI--AIIQDQTFKFLEKLQTLDL 391 L F+ V Y+++ I I +++ L++L + Sbjct: 268 KL------------------FQFFWPRPVEYLNIYNLTITERIDREEFTYSETALKSLMI 309 Query: 392 RD-NALTTIHFIPSIPDIFLSGNKLVTLPKINLTAN-LIHLSENRLENLDILYFLLRVPH 449 + ++ +F N + ++++ IH+ Sbjct: 310 EHVKNQVFLFSKEALYSVFAEMN----IKMLSISDTPFIHMVCPPSP-----------SS 354 Query: 450 LQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYL 509 L QN F+ S Q S L+ L L N L+ ++ L + +S L+ L + Sbjct: 355 FTFLNFTQNVFTD-SVFQGCSTLKRLQTLILQRNGLKNFFKVALMT---KNMSSLETLDV 410 Query: 510 NHNYLNS-LPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPD-- 566 + N LNS + ++ L+L+SN LT LP +++LD+ N++++ D Sbjct: 411 SLNSLNSHAYDRTCAWAESILVLNLSSNMLTGSVFRCLPPKVKVLDLHNNRIMSIPKDVT 470 Query: 567 ---------------------VFVSLSVLD---ITHNKFICECE-LSTFINWLNHTNVTI 601 VF L+ L + N + C C + W+N + + Sbjct: 471 HLQALQELNVASNQLKSVPDGVFDRLTSLQYIWLHDNPWDCTCPGIRYLSEWINKHSGVV 530 Query: 602 AGPPADI 608 + Sbjct: 531 RNSAGSV 537 Score = 78.3 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 61/341 (17%), Positives = 122/341 (35%), Gaps = 29/341 (8%) Query: 268 GFGFHNIKDPDQNTFAGLA---RSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKI 324 ++ D + + L LS + L L +L+VL L++N+I Sbjct: 29 SNELESMVDYSNRNLTHVPKDLPPRTKALSLSQNSISELRMPDISFLSELRVLRLSHNRI 88 Query: 325 NKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQD-QTFKFL 383 + F +L+ L++S+N L + + + ++DL N ++ + F L Sbjct: 89 RSLDFHVFLFNQDLEYLDVSHNRLQNISCC---PMASLRHLDLSFNDFDVLPVCKEFGNL 145 Query: 384 EKLQTLDLRDNALTTIHFIP-----------SIPDIFLSGNKLVTLPKINLTANLIHLSE 432 KL L L + +P + + G + +L N T + Sbjct: 146 TKLTFLGLSAAKFRQLDLLPVAHLHLSCILLDLVSYHIKGGETESLQIPNTTVLHLVFHP 205 Query: 433 NRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPS-LEQLFLGENMLQLAWET 491 N L ++ + + + HLQ+ + N + SE L + ++ W+ Sbjct: 206 NSLFSVQVNMSVNALGHLQLSNIKLNDENCQRLMTFLSELTRGPTLLNVTLQHIETTWKC 265 Query: 492 ELCWDVFEGLSHLQVLYLNHNYLNSLPPG--VFSHLTALRGLSLNS--NRLTVLSHNDLP 547 + F ++ L + + + TAL+ L + N++ + S L Sbjct: 266 SVKLFQFFWPRPVEYLNIYNLTITERIDREEFTYSETALKSLMIEHVKNQVFLFSKEALY 325 Query: 548 A-----NLEILDISRN-QLLAPNPDVFVSLSVLDITHNKFI 582 + N+++L IS + P S + L+ T N F Sbjct: 326 SVFAEMNIKMLSISDTPFIHMVCPPSPSSFTFLNFTQNVFT 366 Score = 53.6 bits (127), Expect = 4e-07, Method: Composition-based stats. Identities = 33/128 (25%), Positives = 52/128 (40%), Gaps = 2/128 (1%) Query: 501 LSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPAN--LEILDISRN 558 + L L+ N ++ L S L+ LR L L+ NR+ L + N LE LD+S N Sbjct: 51 PPRTKALSLSQNSISELRMPDISFLSELRVLRLSHNRIRSLDFHVFLFNQDLEYLDVSHN 110 Query: 559 QLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSG 618 +L + SL LD++ N F F N T + ++ + P + Sbjct: 111 RLQNISCCPMASLRHLDLSFNDFDVLPVCKEFGNLTKLTFLGLSAAKFRQLDLLPVAHLH 170 Query: 619 VSLFSLST 626 +S L Sbjct: 171 LSCILLDL 178 >5Y31-B nrPDB Length = 544 Score = 118 bits (295), Expect = 1e-26, Method: Composition-based stats. Identities = 50/183 (27%), Positives = 77/183 (42%), Gaps = 29/183 (15%) Query: 448 PHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVL 507 P + L ++ F+ S PSL+ L N + + D F GL HL+ L Sbjct: 47 PDVISLSFVRSGFTEISEGSFLFT-PSLQLLLFTSNSFDVISD-----DAFIGLPHLEYL 100 Query: 508 YLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDV 567 ++ +N + S+ F L +L LSL +N L L + Sbjct: 101 FIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKG------------------- 141 Query: 568 FVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTE 627 SL+ +D+ N F C+C+L + WL HTN T+ DIYC P + + SLS++ Sbjct: 142 LDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATV----EDIYCEGPPEYKKRKINSLSSK 197 Query: 628 GCD 630 D Sbjct: 198 DFD 200 Score = 112 bits (281), Expect = 5e-25, Method: Composition-based stats. Identities = 37/168 (22%), Positives = 63/168 (37%), Gaps = 12/168 (7%) Query: 287 RSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYN 346 V L ++ F L++L N + I+D+AF GL +L+ L + N Sbjct: 46 PPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENN 105 Query: 347 LLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI------- 399 + + F GL + ++ L N++ + FK L+ L +DLR N+ Sbjct: 106 NIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLV 165 Query: 400 ----HFIPSIPDIFLSGNKLVTLPKIN-LTANLIHLSENRLENLDILY 442 H ++ DI+ G KIN L++ L Sbjct: 166 EWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLP 213 Score = 72.5 bits (176), Expect = 7e-13, Method: Composition-based stats. Identities = 36/133 (27%), Positives = 54/133 (40%), Gaps = 6/133 (4%) Query: 24 CSFDGRIAFYRFCNLTQVPQVLNT-TERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYT 82 C+ A N +P+ + L + ++ SF F LQLL S + Sbjct: 26 CTCTKDNALCE--NARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSN-S 82 Query: 83 PLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFR 142 I +AF LP+L L + ++ I + F+GL L L L L L F+ Sbjct: 83 FDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNL--QTLPKDIFK 140 Query: 143 NLKALTRLDLSKN 155 L +LT +DL N Sbjct: 141 GLDSLTNVDLRGN 153 Score = 59.8 bits (143), Expect = 4e-09, Method: Composition-based stats. Identities = 48/279 (17%), Positives = 92/279 (32%), Gaps = 16/279 (5%) Query: 46 NTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSS 105 + + LL + N ++ +F L L+ L + + +I + FR L +L L L ++ Sbjct: 71 PSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNN-IKSISRHTFRGLKSLIHLSLANN 129 Query: 106 KIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPS 165 + L D F+GL L + L + K + ++ L + + I Sbjct: 130 NLQTLPKDIFKGLDSLTNVDLRGNSF-NCDCKLKWL--VEWLGHTNATVEDIYCEGPPEY 186 Query: 166 FG-KLNSLKSIDFSSNQIFLVCEHEL--EPLQGKTLSFFSLAANSLYSRVS-----VDWG 217 K+NSL S DF +L + L T S+ + + + ++W Sbjct: 187 KKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWD 246 Query: 218 KCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDP 277 FRN +++G V + A +H F IK Sbjct: 247 HVEKTFRNYD----NITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQ 302 Query: 278 DQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKV 316 D + + + + + F + + Sbjct: 303 DIEILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIYK 341 >4DOM-A nrPDB Length = 141 Score = 110 bits (275), Expect = 3e-24, Method: Composition-based stats. Identities = 35/152 (23%), Positives = 63/152 (41%), Gaps = 17/152 (11%) Query: 687 EPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQD 746 P+ ++DA++C+ D +VQ + + T Y R LC +RD +PG + + Sbjct: 2 MPE--RFDAFICYCPSDIQFVQEMIRQLEQTNY----RLKLCVSDRDVLPGTCVWSIASE 55 Query: 747 AIWNS-RKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMK-HQ 804 I R++V +VS +L+ C +A LS ++ + + K Sbjct: 56 LIEKRCRRMVVVVSDDYLQSKECDFQTKFALS--LSPGAHQKRLI---PIKYKAMKKEFP 110 Query: 805 SIRGFVQKQQYLRWPEDFQDVGWFLHKLSQQI 836 SI F+ Y P WF +L++ + Sbjct: 111 SILRFITVCDYTN-PCTKS---WFWTRLAKAL 138 >6HKW-A nrPDB Length = 363 Score = 106 bits (265), Expect = 3e-23, Method: Composition-based stats. Identities = 65/229 (28%), Positives = 101/229 (44%), Gaps = 35/229 (15%) Query: 366 DLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTA 425 D+ NH I + + F+ L+K++TL LR N + I + +L +L +++L Sbjct: 83 DVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENL----------EELQSLRELDLYD 132 Query: 426 NLIHLSEN-----RLENLDILYFLLR-------VPHLQILILNQNRFSSCSGDQTPSENP 473 N I EN LE LDI + LLR + L+ L L N+ S + S Sbjct: 133 NQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI---ENLSNLH 189 Query: 474 SLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSL 533 L+ L LG N ++ + L++L+ L+L N + L LT L LS+ Sbjct: 190 QLQMLELGSNRIRAIEN-------IDTLTNLESLFLGKNKITKLQN--LDALTNLTVLSM 240 Query: 534 NSNRLTVLSHNDLPANLEILDISRNQLLAPN-PDVFVSLSVLDITHNKF 581 SNRLT + NL L +S N + + L++LDI N+ Sbjct: 241 QSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRI 289 Score = 84.5 bits (207), Expect = 2e-16, Method: Composition-based stats. Identities = 60/273 (21%), Positives = 114/273 (41%), Gaps = 30/273 (10%) Query: 318 NLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQD 377 +L + +I KI E F L ++ L L NL+ + N L + +DL N I I++ Sbjct: 85 DLNHYRIGKI--EGFEVLKKVKTLCLRQNLIKCIE--NLEELQSLRELDLYDNQIKKIEN 140 Query: 378 QTFKFLEKLQTLDLRDNALTTIH---FIPSIPDIFLSGNKLVTLPKIN--LTANLIHLSE 432 + L +L+ LD+ N L I + + +FL NK+ + ++ ++ L Sbjct: 141 --LEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGS 198 Query: 433 NRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETE 492 NR+ ++ + L + L L +N+ + Q +L L + N L Sbjct: 199 NRIRAIENIDTLTNLESL---FLGKNKITKL---QNLDALTNLTVLSMQSNRLTKIEG-- 250 Query: 493 LCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEI 552 + L +L+ LYL+HN + + G+ ++ L L + SNR+ + + L+ Sbjct: 251 -----LQNLVNLRELYLSHNGI-EVIEGLENNNK-LTMLDIASNRIKKIENISHLTELQE 303 Query: 553 LDISRNQLLAPNP----DVFVSLSVLDITHNKF 581 ++ N L + + SL + + N Sbjct: 304 FWMNDNLLESWSDLDELKGARSLETVYLERNPL 336 Score = 79.1 bits (193), Expect = 7e-15, Method: Composition-based stats. Identities = 54/236 (22%), Positives = 96/236 (40%), Gaps = 18/236 (7%) Query: 260 LAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNL 319 L ++ + L + LD+S + ++ L LK L L Sbjct: 119 LEELQSLRELDLYDNQIKKIENLEALTELEI--LDISFNLLRNIEGVD--KLTRLKKLFL 174 Query: 320 AYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQT 379 NKI+KI + L LQ+L L N + + N L + + L KN I +Q+ Sbjct: 175 VNNKISKIEN--LSNLHQLQMLELGSNRIRAIE--NIDTLTNLESLFLGKNKITKLQN-- 228 Query: 380 FKFLEKLQTLDLRDNALTTI---HFIPSIPDIFLSGNKLVTLPKI--NLTANLIHLSENR 434 L L L ++ N LT I + ++ +++LS N + + + N ++ ++ NR Sbjct: 229 LDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNR 288 Query: 435 LENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWE 490 ++ ++ + + LQ +N N S S SLE ++L N LQ + Sbjct: 289 IKKIE---NISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQ 341 Score = 63.7 bits (153), Expect = 4e-10, Method: Composition-based stats. Identities = 58/309 (18%), Positives = 106/309 (34%), Gaps = 73/309 (23%) Query: 115 FQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKS 174 F+ L + L L + L++L LDL NQI+ + + L L+ Sbjct: 97 FEVLKKVKTLCLRQNLIKCI----ENLEELQSLRELDLYDNQIKKI---ENLEALTELEI 149 Query: 175 IDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVS 234 +D S N + + + + L L N + ++ L++L++ Sbjct: 150 LDISFNLLRNIEGVD----KLTRLKKLFLVNNKISKIENLSNLHQ--------LQMLELG 197 Query: 235 GNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLD 294 N AI +++ L Sbjct: 198 SNRIR---------AIENIDTL-------------------------------TNLESLF 217 Query: 295 LSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSS 354 L + L + + L +L VL++ N++ KI E L NL+ L LS+N + + Sbjct: 218 LGKNKITKLQN--LDALTNLTVLSMQSNRLTKI--EGLQNLVNLRELYLSHNGIEVIEG- 272 Query: 355 NFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFI------PSIPDI 408 K+ +D+ N I I++ L +LQ + DN L + + S+ + Sbjct: 273 -LENNNKLTMLDIASNRIKKIEN--ISHLTELQEFWMNDNLLESWSDLDELKGARSLETV 329 Query: 409 FLSGNKLVT 417 +L N L Sbjct: 330 YLERNPLQK 338 Score = 61.7 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 54/207 (26%), Positives = 74/207 (35%), Gaps = 20/207 (9%) Query: 29 RIAFYRFCNLTQVP--QVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTI 86 I F L + L ++L L N I + + L QLQ+LELGS Sbjct: 148 EILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI--ENLSNLHQLQMLELGSNRIR--- 202 Query: 87 DKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKA 146 E L NL L LG +KI L L +L L + L+ +NL Sbjct: 203 AIENIDTLTNLESLFLGKNKITKLQN--LDALTNLTVLSMQSNRLTKI----EGLQNLVN 256 Query: 147 LTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAAN 206 L L LS N I + N L +D +SN+I + L F + N Sbjct: 257 LRELYLSHNGIEVI---EGLENNNKLTMLDIASNRIKKIENIS----HLTELQEFWMNDN 309 Query: 207 SLYSRVSVDWGKCMNPFRNMVLEILDV 233 L S +D K + LE + Sbjct: 310 LLESWSDLDELKGARSLETVYLERNPL 336 Score = 61.7 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 36/200 (18%), Positives = 70/200 (35%), Gaps = 34/200 (17%) Query: 43 QVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDL 102 + L + L L N I+ + + L +L++L++ E L L+ L L Sbjct: 120 EELQSLRELDLYDNQIKKI--ENLEALTELEILDISFNLLRNI---EGVDKLTRLKKLFL 174 Query: 103 GSSKIYFLHPDAFQGLFHLFELRLYFCGLS------------------DAVLKDGYFRNL 144 ++KI + L L L L + + + K L Sbjct: 175 VNNKISKIEN--LSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDAL 232 Query: 145 KALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKT-LSFFSL 203 LT L + N++ + L +L+ + S N I ++ E L+ L+ + Sbjct: 233 TNLTVLSMQSNRLTKI---EGLQNLVNLRELYLSHNGIEVI-----EGLENNNKLTMLDI 284 Query: 204 AANSLYSRVSVDWGKCMNPF 223 A+N + ++ + F Sbjct: 285 ASNRIKKIENISHLTELQEF 304 Score = 56.3 bits (134), Expect = 6e-08, Method: Composition-based stats. Identities = 44/203 (21%), Positives = 85/203 (41%), Gaps = 28/203 (13%) Query: 421 INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL 480 ++ A + L+ R+ ++ L +V L L QN + E SL +L L Sbjct: 77 LDRDAEDVDLNHYRIGKIEGFEVLKKVKTLC---LRQNLIKCI---ENLEELQSLRELDL 130 Query: 481 GENMLQLAWETELCWDV---------------FEGLSHLQVLYLNHNYLNSLPPGVFSHL 525 +N ++ E ++ + L+ L+ L+L +N ++ + S+L Sbjct: 131 YDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIEN--LSNL 188 Query: 526 TALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNP-DVFVSLSVLDITHNKFICE 584 L+ L L SNR+ + + D NLE L + +N++ D +L+VL + N+ Sbjct: 189 HQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKI 248 Query: 585 CELSTFIN----WLNHTNVTIAG 603 L +N +L+H + + Sbjct: 249 EGLQNLVNLRELYLSHNGIEVIE 271 >6O00-A nrPDB Length = 820 Score = 105 bits (261), Expect = 1e-22, Method: Composition-based stats. Identities = 70/400 (17%), Positives = 131/400 (32%), Gaps = 37/400 (9%) Query: 194 QGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSG---NGWTVDITGNFSNAI 250 + L N+ ++ + N + L + +SG + + + Sbjct: 396 EVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLEL 455 Query: 251 SKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFET 310 +A ++ + R ++R L + + + ++ Sbjct: 456 IPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYS- 514 Query: 311 LKDLKVLNLAYN----KINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYID 366 LK L+ L+L N I + L L+VL L N L +L + + Sbjct: 515 LKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLS 573 Query: 367 LQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTAN 426 + +I + K + L L+L L I S L L +I+L N Sbjct: 574 INNEGTKLIVLNSLKKMVNLTELELIRCDLERIPH---------SIFSLHNLQEIDLKDN 624 Query: 427 LIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQ 486 + E + + L L L N + +LE+L+L N ++ Sbjct: 625 NLKTIEEII-------SFQHLHRLTCLKLWYNHIAYIPIQI--GNLTNLERLYLNRNKIE 675 Query: 487 LAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDL 546 L+ L L+HN L LP + L L+ L++ +NR+ L Sbjct: 676 KIPTQLFYC------RKLRYLDLSHNNLTFLPADI-GLLQNLQNLAVTANRIEALPPELF 728 Query: 547 P-ANLEILDISRNQLLAPNPDV--FVSLSVLDITHNKFIC 583 L L + N L + V +L+ +++ N+ C Sbjct: 729 QCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLEC 768 Score = 104 bits (259), Expect = 2e-22, Method: Composition-based stats. Identities = 86/476 (18%), Positives = 165/476 (34%), Gaps = 32/476 (6%) Query: 146 ALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAA 205 + L + + L F L S L+C + L + ++L +S + Sbjct: 298 DIESLTGYRTYRCAHPLATLFKILASFYISLV--IFYGLICMYTLWWMLRRSLKKYSFES 355 Query: 206 NSLYSRVSVDWG--KCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHH 263 S S +++ + + + V ++ N + + + Sbjct: 356 IREESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDK 415 Query: 264 IMGA-GFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFET----LKDLKVLN 318 + + + +G+ + ++L + + L LK L Sbjct: 416 LRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELW 475 Query: 319 LAYNKINKIADEAFYGL-DNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKN----HIA 373 L + KI A L +NL+ L++ + + E+ Y L + + L N + Sbjct: 476 LYHTA-AKIEAPALAFLRENLRALHIKFTDIKEIP-LWIYSLKTLEELHLTGNLSAENNR 533 Query: 374 IIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIP------DIFLSGNKLVTLPKINLTANL 427 I + L++L+ L L+ N + + I G KL+ L + NL Sbjct: 534 YIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNL 593 Query: 428 IHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQL 487 L R + I + + + +LQ + L N + + L L L N + Sbjct: 594 TELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAY 653 Query: 488 AWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHN-DL 546 L++L+ LYLN N + +P +F LR L L+ N LT L + L Sbjct: 654 IPIQ------IGNLTNLERLYLNRNKIEKIPTQLFYCRK-LRYLDLSHNNLTFLPADIGL 706 Query: 547 PANLEILDISRNQLLAPNPDVFVS--LSVLDITHNKFICECELSTFINWLNHTNVT 600 NL+ L ++ N++ A P++F L L + +N + L + Sbjct: 707 LQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELR 762 Score = 92.2 bits (227), Expect = 9e-19, Method: Composition-based stats. Identities = 70/314 (22%), Positives = 113/314 (35%), Gaps = 37/314 (11%) Query: 259 ILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLN 318 L + N + + L R V L + L V + L+ L+ Sbjct: 517 TLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRL---KSNLSKLPQVVTDVGVHLQKLS 573 Query: 319 LAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQ 378 + I + + NL L L L + S F L + IDL+ N++ I++ Sbjct: 574 INNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIF-SLHNLQEIDLKDNNLKTIEEI 632 Query: 379 -TFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLEN 437 +F+ L +L L L N + I + L L ++ L N I Sbjct: 633 ISFQHLHRLTCLKLWYNHIAYIP---------IQIGNLTNLERLYLNRNKIEKIPT---- 679 Query: 438 LDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDV 497 L L+ L L+ N + D +L+ L + N ++ L ++ Sbjct: 680 -----QLFYCRKLRYLDLSHNNLTFLPADI--GLLQNLQNLAVTANRIE-----ALPPEL 727 Query: 498 FEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISR 557 F+ L+ L+L +N L SLP V LT L + L NRL LP L + + Sbjct: 728 FQ-CRKLRALHLGNNVLQSLPSRV-GELTNLTQIELRGNRLEC-----LPVELGECPLLK 780 Query: 558 NQLLAPNPDVFVSL 571 L D+F +L Sbjct: 781 RSGLVVEEDLFSTL 794 Score = 59.8 bits (143), Expect = 5e-09, Method: Composition-based stats. Identities = 58/326 (17%), Positives = 115/326 (35%), Gaps = 63/326 (19%) Query: 34 RFCNLTQVP---QVLNTTERLLLSFN----YIRTVTASSFPFLEQLQLLELGSQYTPLTI 86 +F ++ ++P L T E L L+ N R + L++L++L L S + + Sbjct: 501 KFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLS--KL 558 Query: 87 DKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKA 146 + +L+ L + + + ++ + + +L EL L C L Sbjct: 559 PQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLERIPHSIFSLH---N 615 Query: 147 LTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAAN 206 L +DL N ++++ SF L+ L + N I + P+Q L+ Sbjct: 616 LQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYI------PIQIGNLT------- 662 Query: 207 SLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMG 266 LE L ++ N T L + Sbjct: 663 --------------------NLERLYLNRNKIEKIPT-------------QLFYCRKLRY 689 Query: 267 AGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINK 326 +N+ + GL + ++++L ++ + +L +F+ + L+ L+L N + Sbjct: 690 LDLSHNNLTFLPADI--GLLQ-NLQNLAVTANRIEALPPELFQ-CRKLRALHLGNNVLQS 745 Query: 327 IADEAFYGLDNLQVLNLSYNLLGELY 352 + L NL + L N L L Sbjct: 746 LPSRVGE-LTNLTQIELRGNRLECLP 770 >5XJX-C nrPDB Length = 433 Score = 101 bits (252), Expect = 1e-21, Method: Composition-based stats. Identities = 65/266 (24%), Positives = 103/266 (38%), Gaps = 24/266 (9%) Query: 302 SLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPK 361 + + + L+ L L N + L NL+VL+L N L +F Sbjct: 122 RIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHLNGSIPLSFNRFSG 181 Query: 362 VAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKI 421 + +DL N + L L LDL N L T P++ +L KI Sbjct: 182 LRSLDLSGNRLTGSIPGF--VLPALSVLDLNQNLL-TGPVPPTLTSC-------GSLIKI 231 Query: 422 NLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLG 481 +L+ N + I + R+ L +L L+ NR S + SL+ L L Sbjct: 232 DLSRNRV--------TGPIPESINRLNQLVLLDLSYNRLS-GPFPSSLQGLNSLQALMLK 282 Query: 482 ENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVL 541 N + T + + F+GL +L +L L++ + P + L +LR L L N LT Sbjct: 283 GN---TKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGE 339 Query: 542 SHNDLPA--NLEILDISRNQLLAPNP 565 + +L L ++ N L P P Sbjct: 340 IPLEFRDVKHLSELRLNDNSLTGPVP 365 Score = 101 bits (250), Expect = 2e-21, Method: Composition-based stats. Identities = 60/226 (26%), Positives = 94/226 (41%), Gaps = 28/226 (12%) Query: 440 ILYFLLRVPHLQILILNQ--NRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDV 497 + L R+ HL+ L + R SL+ L L EN EL Sbjct: 97 VSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELG--- 153 Query: 498 FEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISR 557 L++L+VL L+ N+LN P F+ + LR L L+ NRLT + L +LD+++ Sbjct: 154 --NLTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGNRLTGSIPGFVLPALSVLDLNQ 211 Query: 558 NQLLAPNPDVFVSLSVL---DITHNKFICECELS----TFINWLNHTNVTIAGPPADIYC 610 N L P P S L D++ N+ S + L+ + ++GP Sbjct: 212 NLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLNQLVLLDLSYNRLSGP------ 265 Query: 611 VYPDSFSGV-SLFSLSTEGCDE------EEVLKSLKFSLFIVCTVT 649 +P S G+ SL +L +G + E K LK + +V + T Sbjct: 266 -FPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNT 310 Score = 85.2 bits (209), Expect = 1e-16, Method: Composition-based stats. Identities = 62/319 (19%), Positives = 107/319 (33%), Gaps = 57/319 (17%) Query: 59 RTVTASSFPFLEQLQLLELGS--QYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQ 116 R+ + S L+ L+ L P I R +L+ L L + PD Sbjct: 94 RSYVSESLTRLKHLKALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELG 153 Query: 117 GLFHLFELRLYFCGLSDAV-LKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSI 175 L +L L L+ L+ ++ L F L LDLS N++ Sbjct: 154 NLTNLKVLDLHKNHLNGSIPLSFNRFSG---LRSLDLSGNRLTGSIPGFVL--------- 201 Query: 176 DFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSG 235 LS L N L V C G Sbjct: 202 --------------------PALSVLDLNQNLLTGPVPPTLTSC---------------G 226 Query: 236 NGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDL 295 + +D++ N L + ++ ++ + P ++ GL +S++ L L Sbjct: 227 SLIKIDLSRNRVTGPIPESINRL---NQLVLLDLSYNRLSGPFPSSLQGL--NSLQALML 281 Query: 296 SHGFVFS--LNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYS 353 FS + F+ LK+L +L L+ I ++ L++L+VL+L N L Sbjct: 282 KGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGSIPKSLTRLNSLRVLHLEGNNLTGEIP 341 Query: 354 SNFYGLPKVAYIDLQKNHI 372 F + ++ + L N + Sbjct: 342 LEFRDVKHLSELRLNDNSL 360 Score = 81.8 bits (200), Expect = 1e-15, Method: Composition-based stats. Identities = 67/291 (23%), Positives = 104/291 (35%), Gaps = 40/291 (13%) Query: 329 DEAFYGLDNLQVLNLSYNLLGELYSSNFYGL----PKVAYIDLQKNHIAIIQDQTFKFLE 384 E+ L +L+ L LG L + + L++N L Sbjct: 98 SESLTRLKHLKALFFYRC-LGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLT 156 Query: 385 KLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFL 444 L+ LDL N H SIP LS N+ L ++L+ N + Sbjct: 157 NLKVLDLHKN-----HLNGSIP---LSFNRFSGLRSLDLSGNRL----------TGSIPG 198 Query: 445 LRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHL 504 +P L +L LNQN + T + SL ++ L N + + L+ L Sbjct: 199 FVLPALSVLDLNQNLLT-GPVPPTLTSCGSLIKIDLSRNRVTGP-----IPESINRLNQL 252 Query: 505 QVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNR--LTVLSHNDLPA--NLEILDISRNQL 560 +L L++N L+ P L +L+ L L N T + N NL IL +S + Sbjct: 253 VLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNI 312 Query: 561 LAPNPDVF---VSLSVLDITHNKFICECEL----STFINWLNHTNVTIAGP 604 P SL VL + N E L ++ L + ++ GP Sbjct: 313 QGSIPKSLTRLNSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDNSLTGP 363 Score = 80.2 bits (196), Expect = 4e-15, Method: Composition-based stats. Identities = 57/284 (20%), Positives = 100/284 (35%), Gaps = 28/284 (9%) Query: 226 MVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQ------ 279 L+ L + NG+ I N ++ + L H F+ Sbjct: 132 SSLQTLVLRENGFLGPIPDELGN-LTNLKVLDLHKNHLNGSIPLSFNRFSGLRSLDLSGN 190 Query: 280 ---NTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLD 336 + G ++ LDL+ + + L ++L+ N++ E+ L+ Sbjct: 191 RLTGSIPGFVLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPIPESINRLN 250 Query: 337 NLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHI--AIIQDQTFKFLEKLQTLDLRDN 394 L +L+LSYN L + S+ GL + + L+ N I + FK L+ L L L + Sbjct: 251 QLVLLDLSYNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNT 310 Query: 395 ALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILI 454 + G+ +L ++N + ++HL N L +I V HL L Sbjct: 311 NIQ--------------GSIPKSLTRLN-SLRVLHLEGNNLTG-EIPLEFRDVKHLSELR 354 Query: 455 LNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVF 498 LN N + + + +L L N D F Sbjct: 355 LNDNSLTGPVPFERDTVWRMRRKLRLYNNAGLCVNRDSDLDDAF 398 Score = 79.8 bits (195), Expect = 5e-15, Method: Composition-based stats. Identities = 50/210 (23%), Positives = 75/210 (35%), Gaps = 4/210 (1%) Query: 44 VLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLG 103 VL L L+ N + + L ++L I E+ L L +LDL Sbjct: 200 VLPALSVLDLNQNLLTGPVPPTLTSCGSLIKIDLSRNRVTGPI-PESINRLNQLVLLDLS 258 Query: 104 SSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLH 163 +++ P + QGL L L L + + F+ LK L L LS I+ + Sbjct: 259 YNRLSGPFPSSLQGLNSLQALMLKGNTKFSTTIPENAFKGLKNLMILVLSNTNIQGS-IP 317 Query: 164 PSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPF 223 S +LNSL+ + N + E LE K LS L NSL V + Sbjct: 318 KSLTRLNSLRVLHLEGNNLT--GEIPLEFRDVKHLSELRLNDNSLTGPVPFERDTVWRMR 375 Query: 224 RNMVLEILDVSGNGWTVDITGNFSNAISKS 253 R + L D+ F + + Sbjct: 376 RKLRLYNNAGLCVNRDSDLDDAFGSKSGST 405 Score = 62.5 bits (150), Expect = 9e-10, Method: Composition-based stats. Identities = 60/303 (19%), Positives = 102/303 (33%), Gaps = 58/303 (19%) Query: 31 AFYRFCNLTQVPQVLN--------TTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYT 82 A + + L + PQ + + + L+L N L L++L+L + Sbjct: 109 ALFFYRCLGRAPQRIPAFLGRLGSSLQTLVLRENGFLGPIPDELGNLTNLKVLDLHKNHL 168 Query: 83 PLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFR 142 +I F LR LDL +++ P L L L L L+ V Sbjct: 169 NGSIPLS-FNRFSGLRSLDLSGNRLTGSIPGFV--LPALSVLDLNQNLLTGPVPPT--LT 223 Query: 143 NLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFS 202 + +L ++DLS+N++ + S +LN L +D S N++ L+ L +L Sbjct: 224 SCGSLIKIDLSRNRVTG-PIPESINRLNQLVLLDLSYNRLSGPFPSSLQGL--NSLQALM 280 Query: 203 LAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAH 262 L N+ FS I ++ L Sbjct: 281 LKGNT-------------------------------------KFSTTIPENAFKGL---K 300 Query: 263 HIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN 322 ++M NI+ + L +S+R L L + F +K L L L N Sbjct: 301 NLMILVLSNTNIQGSIPKSLTRL--NSLRVLHLEGNNLTGEIPLEFRDVKHLSELRLNDN 358 Query: 323 KIN 325 + Sbjct: 359 SLT 361 >2V9T-B nrPDB Length = 220 Score = 97.2 bits (240), Expect = 3e-20, Method: Composition-based stats. Identities = 42/152 (27%), Positives = 66/152 (43%), Gaps = 3/152 (1%) Query: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348 ++ + L + + F K L+ ++L+ N+I+++A +AF GL +L L L N + Sbjct: 33 TITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKI 92 Query: 349 GELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDI 408 EL S F GL + + L N I ++ F+ L L L L DN L TI P Sbjct: 93 TELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLR 152 Query: 409 FLSGNKLVTLPKINLTANLI---HLSENRLEN 437 + L P I +L N +E Sbjct: 153 AIQTMHLAQNPFICDCHLKWLADYLHTNPIET 184 Score = 93.7 bits (231), Expect = 3e-19, Method: Composition-based stats. Identities = 44/196 (22%), Positives = 77/196 (39%), Gaps = 16/196 (8%) Query: 440 ILYFLLRVPH-LQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVF 498 + +P + + L QN S L ++ L N + +EL D F Sbjct: 23 LTEIPTNLPETITEIRLEQNTIKVIPPGAF-SPYKKLRRIDLSNNQI-----SELAPDAF 76 Query: 499 EGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV--LSHNDLPANLEILDIS 556 +GL L L L N + LP +F L +L+ L LN+N++ + NL +L + Sbjct: 77 QGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLY 136 Query: 557 RNQLLAPNPDVFVSLSVL---DITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYP 613 N+L F L + + N FIC+C L ++L+ + +G C P Sbjct: 137 DNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSG----ARCTSP 192 Query: 614 DSFSGVSLFSLSTEGC 629 + + + ++ Sbjct: 193 RRLANKRIGQIKSKKF 208 Score = 74.4 bits (181), Expect = 2e-13, Method: Composition-based stats. Identities = 50/205 (24%), Positives = 79/205 (38%), Gaps = 29/205 (14%) Query: 16 GPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLL 75 G + +C+ I R LT++P L T + + Sbjct: 1 GSLHCPAACTCSNNIVDCRGKGLTEIPTNLPET-----------------------ITEI 37 Query: 76 ELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAV 135 L T I AF LR +DL +++I L PDAFQGL L L LY +++ Sbjct: 38 RLEQN-TIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITE-- 94 Query: 136 LKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQG 195 L F L +L L L+ N+I L + +F L++L + N++ + + PL+ Sbjct: 95 LPKSLFEGLFSLQLLLLNANKINCLRV-DAFQDLHNLNLLSLYDNKLQTIAKGTFSPLR- 152 Query: 196 KTLSFFSLAANSLYSRVSVDWGKCM 220 + LA N + W Sbjct: 153 -AIQTMHLAQNPFICDCHLKWLADY 176 Score = 58.3 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 29/158 (18%), Positives = 58/158 (36%), Gaps = 17/158 (10%) Query: 343 LSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFI 402 L N + + F K+ IDL N I+ + F+ L L +L L N +T + Sbjct: 39 LEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELP-- 96 Query: 403 PSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSS 462 +L + + L+ L+ N++ N + + +L +L L N+ + Sbjct: 97 -------------KSLFEGLFSLQLLLLNANKI-NCLRVDAFQDLHNLNLLSLYDNKLQT 142 Query: 463 CSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEG 500 + S +++ + L +N + D Sbjct: 143 IAKGTF-SPLRAIQTMHLAQNPFICDCHLKWLADYLHT 179 >3G06-A nrPDB Length = 622 Score = 85.2 bits (209), Expect = 1e-16, Method: Composition-based stats. Identities = 62/292 (21%), Positives = 115/292 (39%), Gaps = 43/292 (14%) Query: 293 LDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELY 352 L++ + +L + + L + + + + L+ L +S N L L Sbjct: 45 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALP-------PELRTLEVSGNQLTSLP 97 Query: 353 SSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIP-SIPDIFLS 411 P + + + N + + L KL + N LT++ +P + ++ +S Sbjct: 98 VLP----PGLLELSIFSNPLTHLPA-LPSGLCKLW---IFGNQLTSLPVLPPGLQELSVS 149 Query: 412 GNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSE 471 N+L +LP + + N+L +L +L LQ L ++ N+ +S P+ Sbjct: 150 DNQLASLPALPSELCKLWAYNNQLTSLPMLP-----SGLQELSVSDNQLASL-----PTL 199 Query: 472 NPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGL 531 L +L+ N L S L+ L ++ N L SLP + L+ L Sbjct: 200 PSELYKLWAYNNRLTSLPAL---------PSGLKELIVSGNRLTSLP----VLPSELKEL 246 Query: 532 SLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDV--FVSLSVLDITHNKF 581 ++ NRLT L LP+ L L + RNQL + S + +++ N Sbjct: 247 MVSGNRLTSLPM--LPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPL 296 Score = 58.6 bits (140), Expect = 1e-08, Method: Composition-based stats. Identities = 52/219 (23%), Positives = 89/219 (40%), Gaps = 28/219 (12%) Query: 389 LDLRDNALTTIHF--IPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLR 446 L++ ++ LTT+ I + + N L +LP + + +S N+L +L +L Sbjct: 45 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLP---- 100 Query: 447 VPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQV 506 P L L + N + P+ L +L++ N L LQ Sbjct: 101 -PGLLELSIFSNPLTHL-----PALPSGLCKLWIFGNQLTSLPVL---------PPGLQE 145 Query: 507 LYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPD 566 L ++ N L SLP + + L L +N+LT L LP+ L+ L +S NQL + P Sbjct: 146 LSVSDNQLASLP----ALPSELCKLWAYNNQLTSLPM--LPSGLQELSVSDNQLASL-PT 198 Query: 567 VFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPP 605 + L L +N+ L + + L + + P Sbjct: 199 LPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLP 237 Score = 55.6 bits (132), Expect = 8e-08, Method: Composition-based stats. Identities = 53/276 (19%), Positives = 96/276 (34%), Gaps = 43/276 (15%) Query: 248 NAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRV 307 NA+ L + A I D + + L +R L++S + SL + Sbjct: 42 NAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALP-PELRTLEVSGNQLTSLPV-L 99 Query: 308 FETLKDLKVLNLAYNKINKIA---------DEAFYGLD----NLQVLNLSYNLLGELY-- 352 L +L + + + + L LQ L++S N L L Sbjct: 100 PPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPAL 159 Query: 353 ----------SSNFYGLP----KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTT 398 ++ LP + + + N +A + L KL +N LT+ Sbjct: 160 PSELCKLWAYNNQLTSLPMLPSGLQELSVSDNQLASLP-TLPSELYKLWA---YNNRLTS 215 Query: 399 IHFIP-SIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQ 457 + +P + ++ +SGN+L +LP + + +S NRL +L +L L L + + Sbjct: 216 LPALPSGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLP-----SGLLSLSVYR 270 Query: 458 NRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETEL 493 N+ + S + L N L L Sbjct: 271 NQLTRLPESLI--HLSSETTVNLEGNPLSERTLQAL 304 Score = 45.9 bits (107), Expect = 7e-05, Method: Composition-based stats. Identities = 52/262 (19%), Positives = 84/262 (32%), Gaps = 36/262 (13%) Query: 36 CNLTQVPQVLNTTERLLLSFNYIRTVTA--------SSFPF-LEQLQLLELGSQYTPLTI 86 NLT +P + L +S N + ++ S F L L L L I Sbjct: 71 NNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALP-SGLCK-LWI 128 Query: 87 DKEAFRNL----PNLRILDLGSSKIYFLH--PDAFQGL----FHLFELRLYFCGLSDAVL 136 +L P L+ L + +++ L P L L L + GL + + Sbjct: 129 FGNQLTSLPVLPPGLQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPMLPSGLQELSV 188 Query: 137 KDGYFRNLKA----LTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVC--EHEL 190 D +L L +L N++ SL PS LK + S N++ + EL Sbjct: 189 SDNQLASLPTLPSELYKLWAYNNRLTSLPALPSG-----LKELIVSGNRLTSLPVLPSEL 243 Query: 191 EPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAI 250 + L SL + + E L + TV++ GN + Sbjct: 244 KELMVSGNRLTSLPMLP----SGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSER 299 Query: 251 SKSQAFSLILAHHIMGAGFGFH 272 + + A G F Sbjct: 300 TLQALREITSAPGYSGPIIRFD 321 >1JL5-A nrPDB Length = 454 Score = 82.1 bits (201), Expect = 8e-16, Method: Composition-based stats. Identities = 67/288 (23%), Positives = 118/288 (40%), Gaps = 34/288 (11%) Query: 323 KINKIADEAFYGLD-NLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFK 381 ++N + + L +L+ L S N L EL + + + N++ + D Sbjct: 77 ELNNLGLSSLPELPPHLESLVASCNSLTELPELP----QSLKSLLVDNNNLKALSDLP-- 130 Query: 382 FLEKLQTLDLRDNALTTIHFI---PSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENL 438 L+ L + +N L + + + I + N L LP + + I N+LE L Sbjct: 131 --PLLEYLGVSNNQLEKLPELQNSSFLKIIDVDNNSLKKLPDLPPSLEFIAAGNNQLEEL 188 Query: 439 DILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVF 498 L +P L + + N P SLE + G N+L+ E Sbjct: 189 PE---LQNLPFLTAIYADNNSLKK-----LPDLPLSLESIVAGNNILEELPE-------L 233 Query: 499 EGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRN 558 + L L +Y ++N L +LP +L L++ N LT L +LP +L LD+S N Sbjct: 234 QNLPFLTTIYADNNLLKTLPD----LPPSLEALNVRDNYLTDLP--ELPQSLTFLDVSEN 287 Query: 559 QLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPA 606 + + ++ +L L+ + N+ C+L + LN +N + PA Sbjct: 288 -IFSGLSELPPNLYYLNASSNEIRSLCDLPPSLEELNVSNNKLIELPA 334 Score = 69.4 bits (168), Expect = 7e-12, Method: Composition-based stats. Identities = 64/402 (15%), Positives = 143/402 (35%), Gaps = 56/402 (13%) Query: 35 FCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNL 94 L+ +P++ E L+ S N + + + L+ L + + K Sbjct: 80 NLGLSSLPELPPHLESLVASCNSLTELPELP----QSLKSLLVDNNNL-----KALSDLP 130 Query: 95 PNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSK 154 P L L + ++++ L Q L + + L L D +L + Sbjct: 131 PLLEYLGVSNNQLEKLPE--LQNSSFLKIIDVDNNSLKK--LPDLP----PSLEFIAAGN 182 Query: 155 NQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSV 214 NQ+ L P L L +I +N + + + PL +++ + L ++ Sbjct: 183 NQLEEL---PELQNLPFLTAIYADNNSLKKLPD---LPLSLESIVAGNNILEELPELQNL 236 Query: 215 DWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNI 274 + + N++ + D+ + +++ N+ + + SL Sbjct: 237 PFLTTIYADNNLLKTLPDLPPSLEALNVRDNYLTDLPEL-PQSLTFL------------- 282 Query: 275 KDPDQNTFAGLAR--SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAF 332 D +N F+GL+ ++ +L+ S + SL L+ LN++ NK+ ++ Sbjct: 283 -DVSENIFSGLSELPPNLYYLNASSNEIRSLCDLPP----SLEELNVSNNKLIELPALP- 336 Query: 333 YGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLR 392 L+ L S+N L E+ + + ++ N + D E ++ L + Sbjct: 337 ---PRLERLIASFNHLAEVPELP----QNLKQLHVEYNPLREFPDIP----ESVEDLRMN 385 Query: 393 DNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENR 434 + ++ + + N L P I + + ++ R Sbjct: 386 SHLAEVPELPQNLKQLHVETNPLREFPDIPESVEDLRMNSER 427 Score = 64.8 bits (156), Expect = 2e-10, Method: Composition-based stats. Identities = 70/405 (17%), Positives = 136/405 (33%), Gaps = 57/405 (14%) Query: 92 RNLPNLRILDLGSSKIYFLHP---DAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKAL- 147 R L + +LG S + L P L EL L ++ + + L L Sbjct: 71 RQAHELELNNLGLSSLPELPPHLESLVASCNSLTELPELPQSLKSLLVDNNNLKALSDLP 130 Query: 148 ---TRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLA 204 L +S NQ+ L P + LK ID +N + + P +L F + Sbjct: 131 PLLEYLGVSNNQLEKL---PELQNSSFLKIIDVDNNSLKKL------PDLPPSLEFIAAG 181 Query: 205 ANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHI 264 N L + + +N+ + + ++ + ++ A + IL Sbjct: 182 NNQL---------EELPELQNLPFLT-AIYADNNSLKKLPDLPLSLESIVAGNNILEELP 231 Query: 265 MGAGFGFHNIKDPDQNTFAGLA--RSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN 322 F D N L S+ L++ ++ L E + L L+++ N Sbjct: 232 ELQNLPFLTTIYADNNLLKTLPDLPPSLEALNVRDNYLTDLP----ELPQSLTFLDVSEN 287 Query: 323 KINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQD----- 377 + +++ NL LN S N + L P + +++ N + + Sbjct: 288 IFSGLSELP----PNLYYLNASSNEIRSLCDLP----PSLEELNVSNNKLIELPALPPRL 339 Query: 378 ----QTFKFL-------EKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTAN 426 +F L + L+ L + N L IP + + L +P++ Sbjct: 340 ERLIASFNHLAEVPELPQNLKQLHVEYNPLREFPDIPESVEDLRMNSHLAEVPELPQNLK 399 Query: 427 LIHLSENRLENL-DILYFLLRVPHLQILILNQNRFSSCSGDQTPS 470 +H+ N L DI + + +++ F+ + D+ Sbjct: 400 QLHVETNPLREFPDIPESVEDLRMNSERVVDPYEFAHETTDKLED 444 Score = 63.7 bits (153), Expect = 3e-10, Method: Composition-based stats. Identities = 75/432 (17%), Positives = 147/432 (34%), Gaps = 62/432 (14%) Query: 176 DFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSG 235 + + +++ + + L+ L SL + V + + + + Sbjct: 59 EMAVSRLRDCLDRQAHELELNNLGLSSLPELPPHLESLVASCNSLTELPELPQSLKSLLV 118 Query: 236 NGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLA--RSSVRHL 293 + + + + + L F I D D N+ L S+ + Sbjct: 119 DNNNLKALSDLPPLLEYLGVSNNQLEKLPELQNSSFLKIIDVDNNSLKKLPDLPPSLEFI 178 Query: 294 DLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYS 353 + + L + L L + N + K+ D +L+ + N+L EL Sbjct: 179 AAGNNQLEELPE--LQNLPFLTAIYADNNSLKKLPDLPL----SLESIVAGNNILEELPE 232 Query: 354 SNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIP-SIPDIFLSG 412 LP + I N + + D L+ L++RDN LT + +P S+ + +S Sbjct: 233 --LQNLPFLTTIYADNNLLKTLPDLP----PSLEALNVRDNYLTDLPELPQSLTFLDVSE 286 Query: 413 NKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSEN 472 N L ++ ++ S N + +L L P L+ L ++ N+ P+ Sbjct: 287 NIFSGLSELPPNLYYLNASSNEIRSLCDLP-----PSLEELNVSNNKLIE-----LPALP 336 Query: 473 PSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLS 532 P LE+L N L E +L+ L++ +N L P Sbjct: 337 PRLERLIASFNHLAEVPEL---------PQNLKQLHVEYNPLREFP-------------- 373 Query: 533 LNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFIN 592 D+P ++E D+ N LA P++ +L L + N ++ + Sbjct: 374 ------------DIPESVE--DLRMNSHLAEVPELPQNLKQLHVETNPLREFPDIPESVE 419 Query: 593 WLNHTNVTIAGP 604 L + + P Sbjct: 420 DLRMNSERVVDP 431 Score = 29.4 bits (64), Expect = 7.8, Method: Composition-based stats. Identities = 11/47 (23%), Positives = 20/47 (42%), Gaps = 4/47 (8%) Query: 34 RFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQ 80 L ++P + ERL+ SFN++ V + L+ L + Sbjct: 325 SNNKLIELPALPPRLERLIASFNHLAEVPELP----QNLKQLHVEYN 367 >4ECN-A nrPDB Length = 876 Score = 78.7 bits (192), Expect = 1e-14, Method: Composition-based stats. Identities = 76/463 (16%), Positives = 155/463 (33%), Gaps = 39/463 (8%) Query: 124 LRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSL-----YLHPSFGKLNSLKSIDFS 178 L L L DA+ ++ + +K +R+ L QI +L ++ + +L L+ I F+ Sbjct: 398 LNLSDL-LQDAINRNPEMKPIKKDSRISLKDTQIGNLTNRITFISKAIQRLTKLQIIYFA 456 Query: 179 SNQIFL---------VCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMV-- 227 ++ + + + LS+ +L + + + F + Sbjct: 457 NSPFTYDNIAVDWEDANSDYAKQYENEELSWSNLKDLTDVELYNCPNMTQLPDFLYDLPE 516 Query: 228 LEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLAR 287 L+ L+++ N + P + + + Sbjct: 517 LQSLNIACNRGISAAQLKADWTRLADDEDTGPKIQIFYMGYNNLEEF--PASASLQKMVK 574 Query: 288 SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNL 347 + LD H V L + F T L L L YN+I +I ++ D ++ L S+N Sbjct: 575 LGL--LDCVHNKVRHLEA--FGTNVKLTDLKLDYNQIEEIPEDFCAFTDQVEGLGFSHNK 630 Query: 348 LGELYSS-NFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLD-----LRDNALTTIHF 401 L + + N + + +D N I ++ + ++ L N + Sbjct: 631 LKYIPNIFNAKSVYVMGSVDFSYNKIGSEGRNISCSMDDYKGINASTVTLSYNEIQKFP- 689 Query: 402 IPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFS 461 ++F +G+ + T+ + +N + S L + L N+ + Sbjct: 690 ----TELFATGSPISTI----ILSNNLMTSIPENSLKPKDGNYKNTYLLTTIDLRFNKLT 741 Query: 462 SCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGV 521 S S D + P L + + N L + N + P Sbjct: 742 SLSDDFRATTLPYLSNMDVSYNCFSSFPTQPLNSSQLKAFGIRHQRDAEGNRILRQWPTG 801 Query: 522 FSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPN 564 + +L L + SN + + L L ILDI+ N ++ + Sbjct: 802 ITTCPSLIQLQIGSNDIRKVD-EKLTPQLYILDIADNPNISID 843 Score = 69.4 bits (168), Expect = 6e-12, Method: Composition-based stats. Identities = 61/379 (16%), Positives = 123/379 (32%), Gaps = 74/379 (19%) Query: 65 SFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSS---KIYFLHPDAFQ----- 116 S+ L+ L +EL +T + +LP L+ L++ + L D + Sbjct: 486 SWSNLKDLTDVEL-YNCPNMTQLPDFLYDLPELQSLNIACNRGISAAQLKADWTRLADDE 544 Query: 117 --GLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKS 174 G + + + L + + + L LD N++R L +FG L Sbjct: 545 DTGPK-IQIFYMGYNNLEEFPASA-SLQKMVKLGLLDCVHNKVRHL---EAFGTNVKLTD 599 Query: 175 IDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVS 234 + NQI + + + + N L ++ K + ++ + Sbjct: 600 LKLDYNQIEEIP-EDFCAFT-DQVEGLGFSHNKLKYIPNIFNAKSVYVMGSVDFSYNKIG 657 Query: 235 GNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLD 294 G + + + I+ S ++ I+ FA S + + Sbjct: 658 SEGRNISCSMDDYKGINASTV------------TLSYNEIQKFPTELFA--TGSPISTII 703 Query: 295 LSHGFVFSLNSRVFETLKD-------LKVLNLAYNKINKIADEAFYG--LDNLQVLNLSY 345 LS+ + S+ + L ++L +NK+ ++D+ F L L +++SY Sbjct: 704 LSNNLMTSIPENSLKPKDGNYKNTYLLTTIDLRFNKLTSLSDD-FRATTLPYLSNMDVSY 762 Query: 346 NLLGE-----LYSSNFYGL------------------------PKVAYIDLQKNHIAIIQ 376 N L SS P + + + N I + Sbjct: 763 NCFSSFPTQPLNSSQLKAFGIRHQRDAEGNRILRQWPTGITTCPSLIQLQIGSNDIRKVD 822 Query: 377 DQTFKFLEKLQTLDLRDNA 395 ++ +L LD+ DN Sbjct: 823 EKLT---PQLYILDIADNP 838 >4PUF-A nrPDB Length = 637 Score = 78.3 bits (191), Expect = 1e-14, Method: Composition-based stats. Identities = 51/236 (21%), Positives = 94/236 (39%), Gaps = 33/236 (13%) Query: 290 VRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDN-LQVLNLSYNLL 348 + L L + + SL + ++K L N++ I L + +Q + LS N + Sbjct: 73 ITTLILDNNELKSLPENL---QGNIKTLYANSNQLTSIP----ATLPDTIQEMELSINRI 125 Query: 349 GELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTI--HFIPSIP 406 EL L +DL N I+ + + + L+ L + DN++ T+ H I Sbjct: 126 TELPERLPSALQS---LDLFHNKISCLPENLPEE---LRYLSVYDNSIRTLPAHLPSEIT 179 Query: 407 DIFLSGNKLVTLPK-INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSG 465 + + N L LP+ + + EN L +L P LQ+L +++N+ + Sbjct: 180 HLNVQSNSLTALPETLPPGLKTLEAGENALTSLPASLP----PELQVLDVSKNQITVLPE 235 Query: 466 DQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGV 521 + P++ L + N L E + LQ++ + N L LP + Sbjct: 236 ----TLPPTITTLDVSRNALTNLPE--------NLPAALQIMQASRNNLVRLPESL 279 Score = 69.0 bits (167), Expect = 8e-12, Method: Composition-based stats. Identities = 43/212 (20%), Positives = 90/212 (42%), Gaps = 25/212 (11%) Query: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLD-NLQVLNLSYNL 347 +++ ++LS + L R+ L+ L+L +NKI+ + + L L+ L++ N Sbjct: 114 TIQEMELSINRITELPERLPSA---LQSLDLFHNKISCLPEN----LPEELRYLSVYDNS 166 Query: 348 LGELYSSNFYGLPK-VAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHF--IPS 404 + L + LP + ++++Q N + + + L+ L+ +NALT++ P Sbjct: 167 IRTLPAH----LPSEITHLNVQSNSLTALPETLPPGLKTLEA---GENALTSLPASLPPE 219 Query: 405 IPDIFLSGNKLVTLPK-INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSC 463 + + +S N++ LP+ + T + +S N L NL LQI+ ++N Sbjct: 220 LQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPAA----LQIMQASRNNLVRL 275 Query: 464 SG--DQTPSENPSLEQLFLGENMLQLAWETEL 493 E P ++ + N + Sbjct: 276 PESLPHFRGEGPQPTRIIVEYNPFSERTIQNM 307 Score = 64.4 bits (155), Expect = 2e-10, Method: Composition-based stats. Identities = 55/240 (22%), Positives = 97/240 (40%), Gaps = 31/240 (12%) Query: 384 EKLQTLDLRDNALTTIHFI--PSIPDIFLSGNKLVTLPK-INLTANLIHLSENRLENLDI 440 E++ TL L +N L ++ +I ++ + N+L ++P + T + LS NR+ L Sbjct: 71 EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELP- 129 Query: 441 LYFLLRVPH-LQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFE 499 R+P LQ L L N+ S + L L + +N ++ Sbjct: 130 ----ERLPSALQSLDLFHNKISCLPE----NLPEELRYLSVYDNSIRTLPA--------H 173 Query: 500 GLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQ 559 S + L + N L +LP + L+ L N LT L LP L++LD+S+NQ Sbjct: 174 LPSEITHLNVQSNSLTALPE---TLPPGLKTLEAGENALTSLPA-SLPPELQVLDVSKNQ 229 Query: 560 LLAPNPDVFVSLSVLDITHNKFICECE-LSTFINWLNHTNVTIAGPPADIYCVYPDSFSG 618 + + +++ LD++ N E L + + + + P F G Sbjct: 230 ITVLPETLPPTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPE-----SLPHFRG 284 Score = 62.5 bits (150), Expect = 7e-10, Method: Composition-based stats. Identities = 43/224 (19%), Positives = 81/224 (36%), Gaps = 21/224 (9%) Query: 203 LAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAH 262 L N R+ + + + + L + N + N I A S L Sbjct: 48 LKNNKTELRLKILGLTTIPAYIPEQITTLILDNNELK-SLPENLQGNIKTLYANSNQLTS 106 Query: 263 HIMGAGFGFHNIKDPDQNTFAGLAR---SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNL 319 + + N L S+++ LDL H + L + ++L+ L++ Sbjct: 107 IPATLPDTIQEM-ELSINRITELPERLPSALQSLDLFHNKISCLPENLP---EELRYLSV 162 Query: 320 AYNKINKIADEAFYGLDN-LQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQ 378 N I + L + + LN+ N L L + P + ++ +N + + Sbjct: 163 YDNSIRTLP----AHLPSEITHLNVQSNSLTALPETLP---PGLKTLEAGENALTSLPAS 215 Query: 379 TFKFLEKLQTLDLRDNALTTIHFI--PSIPDIFLSGNKLVTLPK 420 +LQ LD+ N +T + P+I + +S N L LP+ Sbjct: 216 LP---PELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPE 256 Score = 52.5 bits (124), Expect = 7e-07, Method: Composition-based stats. Identities = 53/361 (14%), Positives = 107/361 (29%), Gaps = 86/361 (23%) Query: 125 RLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLN-SLKSIDFSSNQIF 183 ++ L + LK + L + NQ+ S+ L +++ ++ S N+I Sbjct: 72 QITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIP-----ATLPDTIQEMELSINRIT 126 Query: 184 LVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDIT 243 + E LQ L N + Sbjct: 127 ELPERLPSALQ-----SLDLFHNKI----------------------------------- 146 Query: 244 GNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSL 303 + + ++ D T S + HL++ + +L Sbjct: 147 ---------------SCLPENLPEELRYLSVYDNSIRTLPAHLPSEITHLNVQSNSLTAL 191 Query: 304 NSRVFETLKDLKVLNLAYNKINKIADEAFYGLD-NLQVLNLSYNLLGELYSSNFYGLPKV 362 + LK L+ N + + L LQVL++S N + L + P + Sbjct: 192 PETLPPGLKTLEA---GENALTSLP----ASLPPELQVLDVSKNQITVLPETLP---PTI 241 Query: 363 AYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKIN 422 +D+ +N + + + L+ +Q N L + S+P G + + Sbjct: 242 TTLDVSRNALTNLPENLPAALQIMQA---SRNNLVRLPE--SLPHFRGEGPQPTRIIV-- 294 Query: 423 LTANLIHLSENRLENLDILYFLLRVPHLQIL----ILNQNRFSSCSGDQTPSENPSLEQL 478 SE ++N+ L + ++L + R + SLE+ Sbjct: 295 ---EYNPFSERTIQNMQRLMSSVDYQGPRVLFAMGDFSIVRVTRPLHQAVQGWLTSLEEE 351 Query: 479 F 479 Sbjct: 352 D 352 Score = 52.5 bits (124), Expect = 8e-07, Method: Composition-based stats. Identities = 36/143 (25%), Positives = 65/143 (45%), Gaps = 10/143 (6%) Query: 501 LSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQL 560 + L L++N L SLP + ++ L NSN+LT + LP ++ +++S N++ Sbjct: 70 PEQITTLILDNNELKSLPENLQGNIKTLYA---NSNQLTSIPAT-LPDTIQEMELSINRI 125 Query: 561 LAPNPDVFVSLSVLDITHNKFICECE-LSTFINWLNHTNVTIAGPPADIYCVYPDSFSGV 619 + +L LD+ HNK C E L + +L+ + +I PA + P + + Sbjct: 126 TELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHL----PSEITHL 181 Query: 620 SLFSLSTEGCDEEEVLKSLKFSL 642 ++ S S E + LK Sbjct: 182 NVQSNSLTA-LPETLPPGLKTLE 203 Score = 51.3 bits (121), Expect = 2e-06, Method: Composition-based stats. Identities = 41/178 (23%), Positives = 64/178 (35%), Gaps = 29/178 (16%) Query: 36 CNLTQVPQVLN-TTERLLLSFNYIRTVTASSFPFL-EQLQLLELGSQYTPLTIDKEAFRN 93 LT +P L T + + LS N I + L LQ L+L N Sbjct: 102 NQLTSIPATLPDTIQEMELSINRITELPE----RLPSALQSLDLFHNKISC-----LPEN 152 Query: 94 LP-NLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDL 152 LP LR L + + I L + HL L + + L L+ Sbjct: 153 LPEELRYLSVYDNSIRTLPAHLPSEITHLNVQSNSLTALPETLPPG--------LKTLEA 204 Query: 153 SKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYS 210 +N + SL L+ +D S NQI ++ E L T++ ++ N+L + Sbjct: 205 GENALTSLPAS----LPPELQVLDVSKNQITVLP----ETLP-PTITTLDVSRNALTN 253 >4AY9-X nrPDB Length = 350 Score = 74.8 bits (182), Expect = 2e-13, Method: Composition-based stats. Identities = 52/237 (21%), Positives = 92/237 (38%), Gaps = 27/237 (11%) Query: 296 SHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNL-LGELYSS 354 V + S + +L+ K+ I AF G +L+ + +S N L + + Sbjct: 17 QESKVTEIPSDLPRNAIELR---FVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEAD 73 Query: 355 NFYGLPKVAYIDLQK-NHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGN 413 F LPK+ I ++K N++ I + F+ L LQ L + + + + + I Sbjct: 74 VFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIH------- 126 Query: 414 KLVTLPKINLTANLIHLSENRLENLDILYFLLRVP-HLQILILNQNRFSSCSGDQTPSEN 472 +L L+ + +N + + + IL LN+N Sbjct: 127 --------SLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNSAFNG-- 176 Query: 473 PSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALR 529 L++L L +N EL DVF G S +L ++ ++SLP +L LR Sbjct: 177 TQLDELNLSDNN----NLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLR 229 Score = 56.7 bits (135), Expect = 4e-08, Method: Composition-based stats. Identities = 43/222 (19%), Positives = 77/222 (34%), Gaps = 55/222 (24%) Query: 24 CSFDGRIAFYRFCNLTQVPQVLNTT-------------------------ERLLLSFN-Y 57 C R+ + +T++P L E++ +S N Sbjct: 7 CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDV 66 Query: 58 IRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSS------------ 105 + + A F L +L + + L I+ EAF+NLPNL+ L + ++ Sbjct: 67 LEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIH 126 Query: 106 -------------KIYFLHPDAFQGLFHLFE-LRLYFCGLSDAVLKDGYFRNLKALTRLD 151 I+ + ++F GL L L G+ + + + F L L+ Sbjct: 127 SLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQE--IHNSAFNG-TQLDELN 183 Query: 152 LSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPL 193 LS N + F + +D S +I + + LE L Sbjct: 184 LSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENL 225 Score = 55.2 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 41/208 (19%), Positives = 80/208 (38%), Gaps = 25/208 (12%) Query: 202 SLAANSLYSRVSVDWGKCMNPFRNM---VLEILDVSGNGWTVDITGNFSNAISKSQAFSL 258 L N++ R + + + LE +++S N I + + + K + Sbjct: 27 DLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRI 86 Query: 259 ILAHHIMGAGFG-FHNIKDPDQNTFAGLARSSVRHL--------------DLSHG-FVFS 302 A++++ F N+ + ++ + ++HL D+ + + Sbjct: 87 EKANNLLYINPEAFQNLPNLQYLL---ISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHT 143 Query: 303 LNSRVFETLKDLKVLN-LAYNKINKIADEAFYGLDNLQVLNLS-YNLLGELYSSNFYGLP 360 + F L V+ L N I +I + AF G L LNLS N L EL + F+G Sbjct: 144 IERNSFVGLSFESVILWLNKNGIQEIHNSAFNG-TQLDELNLSDNNNLEELPNDVFHGAS 202 Query: 361 KVAYIDLQKNHIAIIQDQTFKFLEKLQT 388 +D+ + I + + L+KL+ Sbjct: 203 GPVILDISRTRIHSLPSYGLENLKKLRA 230 Score = 44.4 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 25/146 (17%), Positives = 52/146 (35%), Gaps = 10/146 (6%) Query: 441 LYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEG 500 L+ + ++QN S P L ++ + + + + F+ Sbjct: 47 KGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIE----KANNLLYINPEAFQN 102 Query: 501 LSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSN-RLTVLSHND---LPANLEILDIS 556 L +LQ L +++ + LP H L + N + + N L IL ++ Sbjct: 103 LPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLN 162 Query: 557 RNQLLAPNPDVFV--SLSVLDITHNK 580 +N + + F L L+++ N Sbjct: 163 KNGIQEIHNSAFNGTQLDELNLSDNN 188 Score = 35.5 bits (80), Expect = 0.092, Method: Composition-based stats. Identities = 22/100 (22%), Positives = 35/100 (35%), Gaps = 13/100 (13%) Query: 51 LLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFL 110 L L+ N I+ + S+F QL L L + + F ILD+ ++I+ L Sbjct: 159 LWLNKNGIQEIHNSAFNG-TQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSL 217 Query: 111 HPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRL 150 + L L Y + L L +L Sbjct: 218 PSYGLENLKKLRARSTYN------------LKKLPTLEKL 245 Score = 32.5 bits (72), Expect = 0.83, Method: Composition-based stats. Identities = 19/79 (24%), Positives = 30/79 (37%), Gaps = 4/79 (5%) Query: 501 LSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEIL----DIS 556 + L L + G FS L + ++ N + + D+ +NL L Sbjct: 29 PRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEK 88 Query: 557 RNQLLAPNPDVFVSLSVLD 575 N LL NP+ F +L L Sbjct: 89 ANNLLYINPEAFQNLPNLQ 107 >4W8H-A nrPDB Length = 129 Score = 71.0 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 33/144 (22%), Positives = 53/144 (36%), Gaps = 22/144 (15%) Query: 693 YDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSR 752 YD +C++ +D WV N L+ L+ RD PG NI DAI NS Sbjct: 5 YDVNICYAPEDREWVINTLVFKLER-----AGIKTFVNIRDDTPGNFFAENIMDAIENSN 59 Query: 753 KIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMKHQSIRGFVQK 812 + + ++S F ++ C + L+ +I ++ + F+ Sbjct: 60 RTIVVMSPDFFKNNICDKTLQIG-------LSHQIIPILYRP---------CEVPYFLNH 103 Query: 813 QQYLRWPEDFQDVGWFLHKLSQQI 836 YL W D F L + I Sbjct: 104 MTYLDW-CDKDVRPVFWRNLFRDI 126 >1XWD-C nrPDB Length = 252 Score = 69.8 bits (169), Expect = 5e-12, Method: Composition-based stats. Identities = 52/237 (21%), Positives = 92/237 (38%), Gaps = 27/237 (11%) Query: 296 SHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNL-LGELYSS 354 V + S + +L+ K+ I AF G +L+ + +S N L + + Sbjct: 17 QESKVTEIPSDLPRNAIELR---FVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEAD 73 Query: 355 NFYGLPKVAYIDLQK-NHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGN 413 F LPK+ I ++K N++ I + F+ L LQ L + + + + + I Sbjct: 74 VFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIH------- 126 Query: 414 KLVTLPKINLTANLIHLSENRLENLDILYFLLRVP-HLQILILNQNRFSSCSGDQTPSEN 472 +L L+ + +N + + + IL LN+N Sbjct: 127 --------SLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNG-- 176 Query: 473 PSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALR 529 L++L L +N EL DVF G S +L ++ ++SLP +L LR Sbjct: 177 TQLDELNLSDNN----NLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLR 229 Score = 55.2 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 49/256 (19%), Positives = 83/256 (32%), Gaps = 71/256 (27%) Query: 135 VLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSS-NQIFLVCEHELEPL 193 V++ G F L ++++S+N + + F L L I N + + + L Sbjct: 44 VIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNL 103 Query: 194 QGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKS 253 L S + ++ ++ +LD+ N Sbjct: 104 PNLQYL--------LISNTGIKHLPDVHKIHSLQKVLLDIQDNI---------------- 139 Query: 254 QAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKD 313 NI ++N+F GL+ SV Sbjct: 140 -------------------NIHTIERNSFVGLSFESVI---------------------- 158 Query: 314 LKVLNLAYNKINKIADEAFYGLDNLQVLNLS-YNLLGELYSSNFYGLPKVAYIDLQKNHI 372 L L N I +I + AF G L LNLS N L EL + F+G +D+ + I Sbjct: 159 ---LWLNKNGIQEIHNCAFNG-TQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRI 214 Query: 373 AIIQDQTFKFLEKLQT 388 + + L+KL+ Sbjct: 215 HSLPSYGLENLKKLRA 230 Score = 52.1 bits (123), Expect = 1e-06, Method: Composition-based stats. Identities = 43/222 (19%), Positives = 77/222 (34%), Gaps = 55/222 (24%) Query: 24 CSFDGRIAFYRFCNLTQVPQVLNTT-------------------------ERLLLSFN-Y 57 C R+ + +T++P L E++ +S N Sbjct: 7 CHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDV 66 Query: 58 IRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSS------------ 105 + + A F L +L + + L I+ EAF+NLPNL+ L + ++ Sbjct: 67 LEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIH 126 Query: 106 -------------KIYFLHPDAFQGLFHLFE-LRLYFCGLSDAVLKDGYFRNLKALTRLD 151 I+ + ++F GL L L G+ + + + F L L+ Sbjct: 127 SLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQE--IHNCAFNG-TQLDELN 183 Query: 152 LSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPL 193 LS N + F + +D S +I + + LE L Sbjct: 184 LSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENL 225 Score = 36.7 bits (83), Expect = 0.045, Method: Composition-based stats. Identities = 33/152 (21%), Positives = 57/152 (37%), Gaps = 16/152 (10%) Query: 470 SENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNH-NYLNSLPPGVFSHLTAL 528 S LE++ + +N + E DVF L L + + N L + P F +L L Sbjct: 51 SGFGDLEKIEISQNDVLEVIEA----DVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNL 106 Query: 529 RGLSLNSNRLTVLSHNDLPANLEI--LDISRN-QLLAPNPDVFVSLS----VLDITHNKF 581 + L +++ + L +L+ LDI N + + FV LS +L + N Sbjct: 107 QYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGI 166 Query: 582 ----ICECELSTFINWLNHTNVTIAGPPADIY 609 C + N + P D++ Sbjct: 167 QEIHNCAFNGTQLDELNLSDNNNLEELPNDVF 198 Score = 32.5 bits (72), Expect = 0.93, Method: Composition-based stats. Identities = 21/100 (21%), Positives = 34/100 (34%), Gaps = 13/100 (13%) Query: 51 LLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFL 110 L L+ N I+ + +F QL L L + + F ILD+ ++I+ L Sbjct: 159 LWLNKNGIQEIHNCAFNG-TQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSL 217 Query: 111 HPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRL 150 + L L Y + L L +L Sbjct: 218 PSYGLENLKKLRARSTYN------------LKKLPTLEKL 245 Score = 31.3 bits (69), Expect = 2.1, Method: Composition-based stats. Identities = 19/79 (24%), Positives = 30/79 (37%), Gaps = 4/79 (5%) Query: 501 LSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEIL----DIS 556 + L L + G FS L + ++ N + + D+ +NL L Sbjct: 29 PRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEK 88 Query: 557 RNQLLAPNPDVFVSLSVLD 575 N LL NP+ F +L L Sbjct: 89 ANNLLYINPEAFQNLPNLQ 107 >3TSR-E nrPDB Length = 457 Score = 66.3 bits (160), Expect = 5e-11, Method: Composition-based stats. Identities = 68/412 (16%), Positives = 131/412 (31%), Gaps = 30/412 (7%) Query: 147 LTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPL--QGKTLSFFSLA 204 + LD+ Q+ + + + + V ++ L+ SL Sbjct: 1 MMSLDIQCEQLSDARWTELLPLIQQYEVVRLDDCGLTEVRCKDISSAVQANPALTELSLR 60 Query: 205 ANSLYSRVSVDWGKCMNPFRNMV--LEILDVSGNGWTVDITGNFSNAISKSQAFSLILAH 262 N L G + +N ++ L + G T G + + + Sbjct: 61 TNEL---GDGGVGLVLQGLQNPTCKIQKLSLQNCGLTEAGCGILPGMLRSLSTLRELHLN 117 Query: 263 HIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN 322 G + + Q+ L + + + +L+ L + V D K L L+ N Sbjct: 118 DNPMGDAGLKLLCEGLQDPQCRLEKLQLEYCNLTATSCEPL-ASVLRVKADFKELVLSNN 176 Query: 323 KINKIADEAF-YGLD----NLQVLNLSYNLLGELYSSNF----YGLPKVAYIDLQKNHIA 373 +++ GL L+ L L + + + +DL N + Sbjct: 177 DLHEPGVRILCQGLKDSACQLESLKLENCGITAANCKDLCDVVASKASLQELDLSSNKLG 236 Query: 374 IIQDQTFKF---LE--KLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLI 428 L KL+TL L D+ +L +++L +N + Sbjct: 237 NAGIAALCPGLLLPSCKLRTLWL----WECDITAEGCKDLCRVLRAKQSLKELSLASNEL 292 Query: 429 HLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLA 488 RL +L ++ L I + S +++ SL +L + N L Sbjct: 293 KDEGARLLCESLLEPGCQLESLWIKTCSLTAASCPYFCSVLTKSRSLLELQMSSNPLGDE 352 Query: 489 WETELCWDVFEGLSHLQVLYLNHNYL----NSLPPGVFSHLTALRGLSLNSN 536 ELC + + + L+ L+L + S V +LR L L++N Sbjct: 353 GVQELCKALSQPDTVLRELWLGDCDVTNSGCSSLANVLLANRSLRELDLSNN 404 Score = 49.0 bits (115), Expect = 9e-06, Method: Composition-based stats. Identities = 47/252 (18%), Positives = 83/252 (32%), Gaps = 27/252 (10%) Query: 353 SSNFYGLPKVAYIDLQKNHIAIIQDQ-TFKFLEK----LQTLDLRDNALTTIHFIPSIPD 407 SS P + + L+ N + + L+ +Q L L++ LT +P Sbjct: 45 SSAVQANPALTELSLRTNELGDGGVGLVLQGLQNPTCKIQKLSLQNCGLTEAGC-GILPG 103 Query: 408 IFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQ 467 + L TL +++L N + + +L + R+ LQ+ N S Sbjct: 104 ML---RSLSTLRELHLNDNPMGDAGLKLLCEGLQDPQCRLEKLQLEYCNLTATSCEPLAS 160 Query: 468 TPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYL----NSLPPGVFS 523 ++L L N L LC + + L+ L L + + V + Sbjct: 161 VLRVKADFKELVLSNNDLHEPGVRILCQGLKDSACQLESLKLENCGITAANCKDLCDVVA 220 Query: 524 HLTALRGLSLNSNRLTVLSHNDL-------PANLEILDISRNQLLAPNPDVF-------V 569 +L+ L L+SN+L L L L + + A Sbjct: 221 SKASLQELDLSSNKLGNAGIAALCPGLLLPSCKLRTLWLWECDITAEGCKDLCRVLRAKQ 280 Query: 570 SLSVLDITHNKF 581 SL L + N+ Sbjct: 281 SLKELSLASNEL 292 Score = 47.1 bits (110), Expect = 3e-05, Method: Composition-based stats. Identities = 55/345 (15%), Positives = 96/345 (27%), Gaps = 40/345 (11%) Query: 110 LHPDAFQGLFHLFELRLYFCGLSDAVLK---DGYFRNLKALTRLDLSKNQIRSL---YLH 163 + P + L L EL L + DA LK +G L +L L + + L Sbjct: 100 ILPGMLRSLSTLRELHLNDNPMGDAGLKLLCEGLQDPQCRLEKLQLEYCNLTATSCEPLA 159 Query: 164 PSFGKLNSLKSIDFSSNQIFLVCEHEL-EPLQGKTLSFFSLAANSLYSRVSVDWGKCMNP 222 K + S+N + L + L+ SL + + C Sbjct: 160 SVLRVKADFKELVLSNNDLHEPGVRILCQGLKDSACQLESLKLENCGITAANCKDLCDVV 219 Query: 223 FRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTF 282 L+ LD+S N + L + Sbjct: 220 ASKASLQELDLSSNKLGNAGIAALCPGL---------LLPSCKLRTLWLWECDITAEG-C 269 Query: 283 AGLAR-----SSVRHLDLSHGFVFS-----LNSRVFETLKDLKVLNLAYNKINKIADEAF 332 L R S++ L L+ + L + E L+ L + + + F Sbjct: 270 KDLCRVLRAKQSLKELSLASNELKDEGARLLCESLLEPGCQLESLWIKTCSLTAASCPYF 329 Query: 333 YGL----DNLQVLNLSYNLL-----GELYSSNFYGLPKVAYIDLQK----NHIAIIQDQT 379 + +L L +S N L EL + + + L N Sbjct: 330 CSVLTKSRSLLELQMSSNPLGDEGVQELCKALSQPDTVLRELWLGDCDVTNSGCSSLANV 389 Query: 380 FKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLT 424 L+ LDL +N + + + + L L ++ Sbjct: 390 LLANRSLRELDLSNNCMGGPGVLQLLESLKQPSCTLQQLVLYDIY 434 Score = 44.0 bits (102), Expect = 3e-04, Method: Composition-based stats. Identities = 74/477 (15%), Positives = 146/477 (30%), Gaps = 68/477 (14%) Query: 88 KEAFRNLPNLRILDLGSSKIYFLH----PDAFQGLFHLFELRLYFCGLSDAVLKDGYFRN 143 E + ++ L + + A Q L EL L L D + + Sbjct: 17 TELLPLIQQYEVVRLDDCGLTEVRCKDISSAVQANPALTELSLRTNELGDGGV-GLVLQG 75 Query: 144 LKA----LTRLDLSKNQIRSLY---LHPSFGKLNSLKSIDFSSN-----QIFLVCEHELE 191 L+ + +L L + L L++L+ + + N + L+CE + Sbjct: 76 LQNPTCKIQKLSLQNCGLTEAGCGILPGMLRSLSTLRELHLNDNPMGDAGLKLLCEGLQD 135 Query: 192 P---LQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSN 248 P L+ L + +L A S SV K F+ +VL D+ G + G + Sbjct: 136 PQCRLEKLQLEYCNLTATSCEPLASVLRVKA--DFKELVLSNNDLHEPGVRILCQGLKDS 193 Query: 249 AISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVF 308 A + + ++ D + ++S++ LDLS Sbjct: 194 ACQ----LESLKLENCGITAANCKDLCDVVAS------KASLQELDLSSNK--------- 234 Query: 309 ETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSS----NFYGLPKVAY 364 L I + L+ L L + + Sbjct: 235 ----------LGNAGIAALCPGLLLPSCKLRTLWLWECDITAEGCKDLCRVLRAKQSLKE 284 Query: 365 IDLQKNHI-----AIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLP 419 + L N + ++ + + +L++L ++ T S P K +L Sbjct: 285 LSLASNELKDEGARLLCESLLEPGCQLESLWIK----TCSLTAASCPYFCSVLTKSRSLL 340 Query: 420 KINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLF 479 ++ +++N + + + + L + + S N SL +L Sbjct: 341 ELQMSSNPLGDEGVQELCKALSQPDTVLRELWLGDCDVTNSGCSSLANVLLANRSLRELD 400 Query: 480 LGENMLQLAWETELCWDVFEGLSHLQVLYLNH----NYLNSLPPGVFSHLTALRGLS 532 L N + +L + + LQ L L N + + +LR +S Sbjct: 401 LSNNCMGGPGVLQLLESLKQPSCTLQQLVLYDIYWTNEVEEQLRALEEERPSLRIIS 457 Score = 32.5 bits (72), Expect = 0.83, Method: Composition-based stats. Identities = 55/300 (18%), Positives = 94/300 (31%), Gaps = 34/300 (11%) Query: 38 LTQVPQVLNTTERLLLSFNYIRTVT--------ASSFPFLEQLQLLELGSQYTPLTIDKE 89 L V +V + L+LS N + S LE L+L G + Sbjct: 158 LASVLRVKADFKELVLSNNDLHEPGVRILCQGLKDSACQLESLKLENCGITAANCKDLCD 217 Query: 90 AFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTR 149 + +L+ LDL S+K+ A L +L L + + ++L + R Sbjct: 218 VVASKASLQELDLSSNKLGNAGIAALCPGLLLPSCKLRTLWLWECDITAEGCKDLCRVLR 277 Query: 150 LDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHEL-EPLQGKTLSFFSLAANSL 208 SLK + +SN++ L E L SL + Sbjct: 278 ------------------AKQSLKELSLASNELKDEGARLLCESLLEPGCQLESLWIKTC 319 Query: 209 YSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAG 268 + C ++ L L +S N + A+S+ + + Sbjct: 320 SLTAASCPYFCSVLTKSRSLLELQMSSNPLGDEGVQELCKALSQPDT----VLRELWLGD 375 Query: 269 FGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIA 328 N LA S+R LDLS+ + V + L+ LK + ++ Sbjct: 376 CDVTNSGCSSLANVL-LANRSLRELDLSNNCMG--GPGVLQLLESLKQPSCTLQQLVLYD 432 >4PEQ-B nrPDB Length = 456 Score = 66.0 bits (159), Expect = 7e-11, Method: Composition-based stats. Identities = 77/443 (17%), Positives = 149/443 (33%), Gaps = 38/443 (8%) Query: 148 TRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHEL-EPLQ-GKTLSFFSLAA 205 +LD+ Q+ + + + + V ++ LQ +L+ SL Sbjct: 1 MKLDIQCEQLSDARWTELLPLIQQYEVVRLDDCGLTEVRCKDIGSALQANASLTELSLRT 60 Query: 206 NSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIM 265 N L + + ++ +I +S + G + SL + Sbjct: 61 NELGDGGVLLV---LQGLQSPTCKIQKLSLQNCCLTEAGC---GVLPGVLRSLPTLRELH 114 Query: 266 GAGFGFHNIKDPDQNTFAGL--ARSSVRHLDLSHGFVFSLN----SRVFETLKDLKVLNL 319 + + + GL R + L L + + + + + V +DLK L + Sbjct: 115 LSDNPLGDAGL--RLLCEGLLDPRCRLEKLQLEYCSLTAASCEPLAAVLRATRDLKELVV 172 Query: 320 AYNKINKIADEAF-YGLD----NLQVLNLSYNLLGELYSSNFYGL----PKVAYIDLQKN 370 + N I + +A GL L+ L L L + G+ + +DL N Sbjct: 173 SNNDIGEAGVQALCRGLAESACQLETLKLENCGLTAANCKDLCGIVASQASLKDLDLGSN 232 Query: 371 HI-----AIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTA 425 + A + +L+TL L + ++ L +++L Sbjct: 233 RLGDAGLAELCPGLLSPSSQLRTLWL----WECDLTVSGCRELCRVLQAKEALKELSLAG 288 Query: 426 NLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENML 485 N + +L +L ++ L + ++N L +L L N L Sbjct: 289 NSLGDEGAQLLCESLLQPGCQLESLWVKSCGFTAACCQHFSSMLTQNKHLLELQLSSNPL 348 Query: 486 QLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHL----TALRGLSLNSNRLTVL 541 A LC + + + L+VL++ L + G + L +LR L L++N L Sbjct: 349 GDAGVHVLCQALGQPGTVLRVLWVGDCELTNSSCGGLASLLLASPSLRELDLSNNGLGDP 408 Query: 542 SHNDLPANLEILDISRNQLLAPN 564 L +LE S QL+ + Sbjct: 409 GVLQLLGSLEQPACSLEQLVLYD 431 Score = 50.9 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 55/374 (14%), Positives = 100/374 (26%), Gaps = 66/374 (17%) Query: 82 TPLTIDKEAFRNLPNLRILDLGSSK-----IYFLHPDAFQGLFHLFELRLYFCGLSDAVL 136 + R+LP LR L L + + L L +L+L +C L+ A Sbjct: 95 AGCGVLPGVLRSLPTLRELHLSDNPLGDAGLRLLCEGLLDPRCRLEKLQLEYCSLTAASC 154 Query: 137 K--DGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQ 194 + R + L L +S N D + +C L Sbjct: 155 EPLAAVLRATRDLKELVVSNN--------------------DIGEAGVQALCR----GLA 190 Query: 195 GKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNA-ISKS 253 +L + + C L+ LD+ N +S S Sbjct: 191 ESACQLETLKLENCGLTAANCKDLCGIVASQASLKDLDLGSNRLGDAGLAELCPGLLSPS 250 Query: 254 QAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLAR-----SSVRHLDLSHGFVFS-----L 303 + D + L R +++ L L+ + L Sbjct: 251 SQLRTLWLWEC-----------DLTVSGCRELCRVLQAKEALKELSLAGNSLGDEGAQLL 299 Query: 304 NSRVFETLKDLKVLNLAYNKINKIADEAFYGL----DNLQVLNLSYNLL-----GELYSS 354 + + L+ L + + F + +L L LS N L L + Sbjct: 300 CESLLQPGCQLESLWVKSCGFTAACCQHFSSMLTQNKHLLELQLSSNPLGDAGVHVLCQA 359 Query: 355 NFYGLPKVAYIDLQKNHIAIIQDQTFKFL----EKLQTLDLRDNALTTIHFIPSIPDIFL 410 + + + + L L+ LDL +N L + + + Sbjct: 360 LGQPGTVLRVLWVGDCELTNSSCGGLASLLLASPSLRELDLSNNGLGDPGVLQLLGSLEQ 419 Query: 411 SGNKLVTLPKINLT 424 L L ++ Sbjct: 420 PACSLEQLVLYDIY 433 Score = 48.6 bits (114), Expect = 1e-05, Method: Composition-based stats. Identities = 46/247 (18%), Positives = 75/247 (30%), Gaps = 43/247 (17%) Query: 378 QTFKFLEKLQTLDLRDNALTTIHFI----------PSIPDIFLSGNKLV----------- 416 + L L LR N L + I + L L Sbjct: 45 SALQANASLTELSLRTNELGDGGVLLVLQGLQSPTCKIQKLSLQNCCLTEAGCGVLPGVL 104 Query: 417 ----TLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSEN 472 TL +++L+ N + + RL +L R+ LQ+ + S Sbjct: 105 RSLPTLRELHLSDNPLGDAGLRLLCEGLLDPRCRLEKLQLEYCSLTAASCEPLAAVLRAT 164 Query: 473 PSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYL----NSLPPGVFSHLTAL 528 L++L + N + A LC + E L+ L L + L G+ + +L Sbjct: 165 RDLKELVVSNNDIGEAGVQALCRGLAESACQLETLKLENCGLTAANCKDLCGIVASQASL 224 Query: 529 RGLSLNSNRLTVLSHNDL-------PANLEILDISRNQLLAPNPDVF-------VSLSVL 574 + L L SNRL +L + L L + L +L L Sbjct: 225 KDLDLGSNRLGDAGLAELCPGLLSPSSQLRTLWLWECDLTVSGCRELCRVLQAKEALKEL 284 Query: 575 DITHNKF 581 + N Sbjct: 285 SLAGNSL 291 Score = 48.6 bits (114), Expect = 1e-05, Method: Composition-based stats. Identities = 70/323 (21%), Positives = 114/323 (35%), Gaps = 25/323 (7%) Query: 38 LTQVPQVLNTTERLLLSFNYIR----TVTASSF----PFLEQLQLLELGSQYTPLTIDKE 89 L V + L T L LS N + + LE+LQL Sbjct: 100 LPGVLRSLPTLRELHLSDNPLGDAGLRLLCEGLLDPRCRLEKLQLEYCSLTAASCEPLAA 159 Query: 90 AFRNLPNLRILDLGSSKIYFLHPDAF-QGLF----HLFELRLYFCGLSDAVLKD--GYFR 142 R +L+ L + ++ I A +GL L L+L CGL+ A KD G Sbjct: 160 VLRATRDLKELVVSNNDIGEAGVQALCRGLAESACQLETLKLENCGLTAANCKDLCGIVA 219 Query: 143 NLKALTRLDLSKNQIRSLYLHPSFGKLNS----LKSIDFSSNQIF-LVCEHELEPLQGKT 197 + +L LDL N++ L L S L+++ + C LQ K Sbjct: 220 SQASLKDLDLGSNRLGDAGLAELCPGLLSPSSQLRTLWLWECDLTVSGCRELCRVLQAKE 279 Query: 198 -LSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAF 256 L SLA NSL + + + LE L V G+T +FS+ +++++ Sbjct: 280 ALKELSLAGNSLGDEGAQLLCESL-LQPGCQLESLWVKSCGFTAACCQHFSSMLTQNKHL 338 Query: 257 SLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKV 316 + G H + L V +L++ L + + L+ Sbjct: 339 LELQLSSNPLGDAGVHVLCQALGQPGTVLRVLWVGDCELTNSSCGGL-ASLLLASPSLRE 397 Query: 317 LNLAYNKINKIADEAFYGLDNLQ 339 L+L+ N + L +L+ Sbjct: 398 LDLSNNGLG--DPGVLQLLGSLE 418 Score = 45.9 bits (107), Expect = 7e-05, Method: Composition-based stats. Identities = 59/422 (13%), Positives = 120/422 (28%), Gaps = 58/422 (13%) Query: 113 DAFQGLFHLFELRLYFCGLSDA---VLKDGYFRNLKALTRLDLSKNQIRSLY---LHPSF 166 A Q L EL L L D ++ G + +L L + L Sbjct: 45 SALQANASLTELSLRTNELGDGGVLLVLQGLQSPTCKIQKLSLQNCCLTEAGCGVLPGVL 104 Query: 167 GKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFS---LAANSLYSRVSVDWGKCMNPF 223 L +L+ + S N PL L L ++ +++ Sbjct: 105 RSLPTLRELHLSDN-----------PLGDAGLRLLCEGLLDPRCRLEKLQLEYCSLTAAS 153 Query: 224 RNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFA 283 + +L + + + ++ N + N Sbjct: 154 CEPLAAVLRATRDLKELVVSNNDIGEAGVQALCRGLAESACQLETLKLENC--------- 204 Query: 284 GLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKI-----NKIADEAFYGLDNL 338 GL ++ + L + + LK L+L N++ ++ L Sbjct: 205 GLTAANCKDLC-----------GIVASQASLKDLDLGSNRLGDAGLAELCPGLLSPSSQL 253 Query: 339 QVLNLSYNLLGELYSS----NFYGLPKVAYIDLQKNHI-----AIIQDQTFKFLEKLQTL 389 + L L L + + L N + ++ + + +L++L Sbjct: 254 RTLWLWECDLTVSGCRELCRVLQAKEALKELSLAGNSLGDEGAQLLCESLLQPGCQLESL 313 Query: 390 DLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPH 449 ++ T L+ NK L ++ L++N + + + + + Sbjct: 314 WVKSCGFTA--ACCQHFSSMLTQNK--HLLELQLSSNPLGDAGVHVLCQALGQPGTVLRV 369 Query: 450 LQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYL 509 L + S +PSL +L L N L +L + + L+ L L Sbjct: 370 LWVGDCELTNSSCGGLASLLLASPSLRELDLSNNGLGDPGVLQLLGSLEQPACSLEQLVL 429 Query: 510 NH 511 Sbjct: 430 YD 431 >2BNH-A nrPDB Length = 457 Score = 64.8 bits (156), Expect = 2e-10, Method: Composition-based stats. Identities = 71/452 (15%), Positives = 135/452 (29%), Gaps = 33/452 (7%) Query: 148 TRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPL--QGKTLSFFSLAA 205 LD+ Q+ L + + + ++ +L+ L Sbjct: 2 MNLDIHCEQLSDARWTELLPLLQQYEVVRLDDCGLTEEHCKDIGSALRANPSLTELCLRT 61 Query: 206 NSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIM 265 N L + + ++ L + T G + + + Sbjct: 62 NELGDAGVHLVLQGLQS-PTCKIQKLSLQNCSLTEAGCGVLPSTLRSLPTLRELHLSDNP 120 Query: 266 GAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKIN 325 G + + + L + + + L+ L + V + LK L ++ N I Sbjct: 121 LGDAGLRLLCEGLLDPQCHLEKLQLEYCRLTAASCEPL-ASVLRATRALKELTVSNNDIG 179 Query: 326 KIADEAF-YGLD----NLQVLNLSYNLLGELYSSNFYGL----PKVAYIDLQKNH----- 371 + GL L+ L L L + G+ + +DL N Sbjct: 180 EAGARVLGQGLADSACQLETLRLENCGLTPANCKDLCGIVASQASLRELDLGSNGLGDAG 239 Query: 372 IAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLS 431 IA + +L+TL L D+ TL +++L N + Sbjct: 240 IAELCPGLLSPASRLKTLWL----WECDITASGCRDLCRVLQAKETLKELSLAGNKLGDE 295 Query: 432 ENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWET 491 RL +L ++ L + + ++N L +L L N L + Sbjct: 296 GARLLCESLLQPGCQLESLWVKSCSLTAACCQHVSLMLTQNKHLLELQLSSNKLGDSGIQ 355 Query: 492 ELCWDVFEGLSHLQVLYLNHNYL----NSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLP 547 ELC + + + L+VL L + S + +LR L L++N + L Sbjct: 356 ELCQALSQPGTTLRVLCLGDCEVTNSGCSSLASLLLANRSLRELDLSNNCVGDPGVLQLL 415 Query: 548 AN-------LEILDISRNQLLAPNPDVFVSLS 572 + LE L + D +L Sbjct: 416 GSLEQPGCALEQLVLYDTYWTEEVEDRLQALE 447 Score = 57.1 bits (136), Expect = 3e-08, Method: Composition-based stats. Identities = 60/372 (16%), Positives = 111/372 (29%), Gaps = 34/372 (9%) Query: 46 NTTERLLLSFNYIRTVT--------ASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNL 97 + L L N + S +++L L + R+LP L Sbjct: 52 PSLTELCLRTNELGDAGVHLVLQGLQSPTCKIQKLSLQNCSLTEAGCGVLPSTLRSLPTL 111 Query: 98 RILDLGSSK-----IYFLHPDAFQGLFHLFELRLYFCGLSDAVLK--DGYFRNLKALTRL 150 R L L + + L HL +L+L +C L+ A + R +AL L Sbjct: 112 RELHLSDNPLGDAGLRLLCEGLLDPQCHLEKLQLEYCRLTAASCEPLASVLRATRALKEL 171 Query: 151 DLSKNQIRSLYLHPSFGKLN----SLKSIDFSSNQIFLVCEHELEPL--QGKTLSFFSLA 204 +S N I L L+++ + + +L + +L L Sbjct: 172 TVSNNDIGEAGARVLGQGLADSACQLETLRLENCGLTPANCKDLCGIVASQASLRELDLG 231 Query: 205 ANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHI 264 +N L + L+ L + T + + + + Sbjct: 232 SNGL-GDAGIAELCPGLLSPASRLKTLWLWECDITASGCRDLCRVLQAKETLKELSLAGN 290 Query: 265 MGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNK- 323 G + + L V+ L+ ++ + + K L L L+ NK Sbjct: 291 KLGDEGARLLCESLLQPGCQLESLWVKSCSLTAACCQHVSLMLTQN-KHLLELQLSSNKL 349 Query: 324 ----INKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGL----PKVAYIDLQKNHIAII 375 I ++ L+VL L + S+ L + +DL N + Sbjct: 350 GDSGIQELCQALSQPGTTLRVLCLGDCEVTNSGCSSLASLLLANRSLRELDLSNNC--VG 407 Query: 376 QDQTFKFLEKLQ 387 + L L+ Sbjct: 408 DPGVLQLLGSLE 419 Score = 45.9 bits (107), Expect = 7e-05, Method: Composition-based stats. Identities = 52/274 (18%), Positives = 95/274 (34%), Gaps = 31/274 (11%) Query: 335 LDNLQVLNLSYNLLGELYS----SNFYGLPKVAYIDLQKNHI-AIIQDQTFKFLE----K 385 L +V+ L L E + S P + + L+ N + + L+ K Sbjct: 23 LQQYEVVRLDDCGLTEEHCKDIGSALRANPSLTELCLRTNELGDAGVHLVLQGLQSPTCK 82 Query: 386 LQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLL 445 +Q L L++ +LT + + L TL +++L+ N + + RL +L Sbjct: 83 IQKLSLQNCSLT----EAGCGVLPSTLRSLPTLRELHLSDNPLGDAGLRLLCEGLLDPQC 138 Query: 446 RVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQ 505 + LQ+ S +L++L + N + A L + + L+ Sbjct: 139 HLEKLQLEYCRLTAASCEPLASVLRATRALKELTVSNNDIGEAGARVLGQGLADSACQLE 198 Query: 506 VLYLNHNYL----NSLPPGVFSHLTALRGLSLNSNRLTVLSHNDL-------PANLEILD 554 L L + L G+ + +LR L L SN L +L + L+ L Sbjct: 199 TLRLENCGLTPANCKDLCGIVASQASLRELDLGSNGLGDAGIAELCPGLLSPASRLKTLW 258 Query: 555 ISRNQLLAPNPDVF-------VSLSVLDITHNKF 581 + + A +L L + NK Sbjct: 259 LWECDITASGCRDLCRVLQAKETLKELSLAGNKL 292 Score = 44.0 bits (102), Expect = 3e-04, Method: Composition-based stats. Identities = 61/340 (17%), Positives = 102/340 (30%), Gaps = 35/340 (10%) Query: 38 LTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNL 97 L + L T L LS N + L+LL G ++K L Sbjct: 101 LPSTLRSLPTLRELHLSDNPLGD---------AGLRLLCEGLLDPQCHLEK------LQL 145 Query: 98 RILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDA---VLKDGYFRNLKALTRLDLSK 154 L ++ L + L EL + + +A VL G + L L L Sbjct: 146 EYCRLTAASCEPLA-SVLRATRALKELTVSNNDIGEAGARVLGQGLADSACQLETLRLEN 204 Query: 155 NQIRSLY---LHPSFGKLNSLKSIDFSSNQIFLVCEHELEP-LQGKTLSFFSLAANSLYS 210 + L SL+ +D SN + EL P L +L Sbjct: 205 CGLTPANCKDLCGIVASQASLRELDLGSNGLGDAGIAELCPGLLSPASRLKTLWLWECDI 264 Query: 211 RVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLIL---AHHIMGA 267 S C L+ L ++GN + ++ + L + + A Sbjct: 265 TASGCRDLCRVLQAKETLKELSLAGNKLGDEGARLLCESLLQPGCQLESLWVKSCSLTAA 324 Query: 268 GFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKI 327 ++ L SS + L + L + + L+VL L ++ Sbjct: 325 CCQHVSLMLTQNKHLLELQLSSNK---LGDSGIQELCQALSQPGTTLRVLCLGDCEVTNS 381 Query: 328 ADEAFYGL----DNLQVLNLSYNLLGELYSSNFYGLPKVA 363 + L +L+ L+LS N +G L + Sbjct: 382 GCSSLASLLLANRSLRELDLSNNCVG--DPGVLQLLGSLE 419 >1M9S-A nrPDB Length = 605 Score = 64.0 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 49/192 (25%), Positives = 78/192 (40%), Gaps = 17/192 (8%) Query: 370 NHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPD---IFLSGNKLVTLPKINLTAN 426 N+ I Q ++L + L L N LT I + ++ + +FL NK+ L + Sbjct: 51 NNSDIKSVQGIQYLPNVTKLFLNGNKLTDIKPLTNLKNLGWLFLDENKIKDLSSLKDLKK 110 Query: 427 LIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQ 486 L LS DI L+ +P L+ L L N+ + S L+ L L +N + Sbjct: 111 LKSLSLEHNGISDING-LVHLPQLESLYLGNNKITDI---TVLSRLTKLDTLSLEDNQIS 166 Query: 487 LAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDL 546 GL+ LQ LYL+ N+++ L + L L L L S N Sbjct: 167 DIVP-------LAGLTKLQNLYLSKNHISDL--RALAGLKNLDVLELFSQECLNKPINH- 216 Query: 547 PANLEILDISRN 558 +NL + + +N Sbjct: 217 QSNLVVPNTVKN 228 Score = 61.3 bits (147), Expect = 2e-09, Method: Composition-based stats. Identities = 39/183 (21%), Positives = 71/183 (38%), Gaps = 37/183 (20%) Query: 394 NALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQIL 453 ++ I ++P++ +FL+GNKL + L + +L L Sbjct: 56 KSVQGIQYLPNVTKLFLNGNKLTDIKP-----------------------LTNLKNLGWL 92 Query: 454 ILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNY 513 L++N+ S + + SL N + + L L+ LYL +N Sbjct: 93 FLDENKIKDLSSLKDLKKLKSLSL---EHNGISDI-------NGLVHLPQLESLYLGNNK 142 Query: 514 LNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSV 573 + + V S LT L LSL N+++ + L+ L +S+N + + L Sbjct: 143 ITDIT--VLSRLTKLDTLSLEDNQISDIVPLAGLTKLQNLYLSKNHIS--DLRALAGLKN 198 Query: 574 LDI 576 LD+ Sbjct: 199 LDV 201 Score = 59.4 bits (142), Expect = 7e-09, Method: Composition-based stats. Identities = 26/92 (28%), Positives = 39/92 (42%), Gaps = 8/92 (8%) Query: 278 DQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDN 337 D N L + + L L + + + V L L L+L N+I+ I A GL Sbjct: 123 DINGLVHLPQ--LESLYLGNNKITDI--TVLSRLTKLDTLSLEDNQISDIVPLA--GLTK 176 Query: 338 LQVLNLSYNLLGELYSSNFYGLPKVAYIDLQK 369 LQ L LS N + +L GL + ++L Sbjct: 177 LQNLYLSKNHISDLR--ALAGLKNLDVLELFS 206 Score = 58.3 bits (139), Expect = 1e-08, Method: Composition-based stats. Identities = 41/172 (23%), Positives = 55/172 (31%), Gaps = 30/172 (17%) Query: 25 SFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPL 84 S D IA Q Q L +L L+ N + + L+ L L L Sbjct: 44 SIDQIIANNSDIKSVQGIQYLPNVTKLFLNGNKLTDIKP--LTNLKNLGWLFLDENKIKD 101 Query: 85 TI-------------------DKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELR 125 D +LP L L LG++KI + L L L Sbjct: 102 LSSLKDLKKLKSLSLEHNGISDINGLVHLPQLESLYLGNNKITDI--TVLSRLTKLDTLS 159 Query: 126 LYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDF 177 L +SD V L L L LSKN I L + L +L ++ Sbjct: 160 LEDNQISDIV----PLAGLTKLQNLYLSKNHISDL---RALAGLKNLDVLEL 204 Score = 54.8 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 32/196 (16%), Positives = 65/196 (33%), Gaps = 29/196 (14%) Query: 56 NYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAF 115 + ++ + + +L ++ + + LPN+ L L +K+ + P Sbjct: 26 DNLKKKSVTDAVTQNELNSIDQIIANNSDIKSVQGIQYLPNVTKLFLNGNKLTDIKP--L 83 Query: 116 QGLFHLFELRLYFCGL------------------SDAVLKDGYFRNLKALTRLDLSKNQI 157 L +L L L + + + +L L L L N+I Sbjct: 84 TNLKNLGWLFLDENKIKDLSSLKDLKKLKSLSLEHNGISDINGLVHLPQLESLYLGNNKI 143 Query: 158 RSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQG-KTLSFFSLAANSLYSRVSVDW 216 + +L L ++ NQI ++ PL G L L+ N + ++ Sbjct: 144 TDI---TVLSRLTKLDTLSLEDNQIS-----DIVPLAGLTKLQNLYLSKNHISDLRALAG 195 Query: 217 GKCMNPFRNMVLEILD 232 K ++ E L+ Sbjct: 196 LKNLDVLELFSQECLN 211 Score = 51.7 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 35/189 (18%), Positives = 70/189 (37%), Gaps = 34/189 (17%) Query: 321 YNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTF 380 N + + + L N+ L L+ N L ++ L + ++ L +N I + Sbjct: 50 ANNSDIKSVQGIQYLPNVTKLFLNGNKLTDIKP--LTNLKNLGWLFLDENKIKDLSSLKD 107 Query: 381 KFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDI 440 ++L L N ++ I+ + +P + ++L N++ ++ + Sbjct: 108 LKKL--KSLSLEHNGISDINGLVHLPQLES-----------------LYLGNNKITDITV 148 Query: 441 LYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEG 500 L R+ L L L N+ S + L+ L+L +N + G Sbjct: 149 ---LSRLTKLDTLSLEDNQISDIVP---LAGLTKLQNLYLSKNHISDL-------RALAG 195 Query: 501 LSHLQVLYL 509 L +L VL L Sbjct: 196 LKNLDVLEL 204 Score = 50.9 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 31/160 (19%), Positives = 62/160 (38%), Gaps = 16/160 (10%) Query: 424 TANLIHLSENRLENLDILYFLLR---VPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL 480 T N ++ + + N + + +P++ L LN N+ + + + +L LFL Sbjct: 38 TQNELNSIDQIIANNSDIKSVQGIQYLPNVTKLFLNGNKLTDI---KPLTNLKNLGWLFL 94 Query: 481 GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV 540 EN ++ + + HN ++ + HL L L L +N++T Sbjct: 95 DENKIKDLSSLKDLKKLKSLSL-------EHNGISDI--NGLVHLPQLESLYLGNNKITD 145 Query: 541 LSHNDLPANLEILDISRNQLLAPNPDV-FVSLSVLDITHN 579 ++ L+ L + NQ+ P L L ++ N Sbjct: 146 ITVLSRLTKLDTLSLEDNQISDIVPLAGLTKLQNLYLSKN 185 >5YXM-A nrPDB Length = 203 Score = 64.0 bits (154), Expect = 3e-10, Method: Composition-based stats. Identities = 33/135 (24%), Positives = 59/135 (43%), Gaps = 8/135 (5%) Query: 291 RHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGE 350 +HL LS + ++S +++L++L+L N I KI + D L+ L +SYN + Sbjct: 56 KHLALSTNNIEKISS--LSGMENLRILSLGRNLIKKIENLDAVA-DTLEELWISYNQIAS 112 Query: 351 LYSSNFYGLPKVAYIDLQKNHIAI-IQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIF 409 L S L + + + N I + L+KL+ L L N L + + + Sbjct: 113 L--SGIEKLVNLRVLYMSNNKITNWGEIDKLAALDKLEDLLLAGNPLYNDYKENNATSEY 170 Query: 410 LSG--NKLVTLPKIN 422 +L L K++ Sbjct: 171 RIEVVKRLPNLKKLD 185 Score = 52.1 bits (123), Expect = 1e-06, Method: Composition-based stats. Identities = 31/159 (19%), Positives = 63/159 (39%), Gaps = 26/159 (16%) Query: 355 NFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNK 414 L ++ L N+I I + +E L+ L L N + I + ++ D Sbjct: 48 TLSTLKACKHLALSTNNIEKIS--SLSGMENLRILSLGRNLIKKIENLDAVAD------- 98 Query: 415 LVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPS 474 TL ++ ++ N I L + ++ +L++L ++ N+ ++ + Sbjct: 99 --TLEELWISYNQI----------ASLSGIEKLVNLRVLYMSNNKITNWGEIDKLAALDK 146 Query: 475 LEQLFLGENML-----QLAWETELCWDVFEGLSHLQVLY 508 LE L L N L + +E +V + L +L+ L Sbjct: 147 LEDLLLAGNPLYNDYKENNATSEYRIEVVKRLPNLKKLD 185 Score = 51.7 bits (122), Expect = 2e-06, Method: Composition-based stats. Identities = 24/120 (20%), Positives = 46/120 (38%), Gaps = 12/120 (10%) Query: 466 DQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHL 525 D T S + + L L N ++ G+ +L++L L N + + + + Sbjct: 46 DATLSTLKACKHLALSTNNIEKISS-------LSGMENLRILSLGRNLIKKI-ENLDAVA 97 Query: 526 TALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNP----DVFVSLSVLDITHNKF 581 L L ++ N++ LS + NL +L +S N++ L L + N Sbjct: 98 DTLEELWISYNQIASLSGIEKLVNLRVLYMSNNKITNWGEIDKLAALDKLEDLLLAGNPL 157 Score = 40.5 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 20/81 (24%), Positives = 33/81 (40%), Gaps = 5/81 (6%) Query: 28 GRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTID 87 GR + NL V L E L +S+N I ++ S L L++L + + + Sbjct: 83 GRNLIKKIENLDAVADTL---EELWISYNQIASL--SGIEKLVNLRVLYMSNNKITNWGE 137 Query: 88 KEAFRNLPNLRILDLGSSKIY 108 + L L L L + +Y Sbjct: 138 IDKLAALDKLEDLLLAGNPLY 158 Score = 37.8 bits (86), Expect = 0.019, Method: Composition-based stats. Identities = 22/89 (24%), Positives = 37/89 (41%), Gaps = 4/89 (4%) Query: 519 PGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPN--PDVFVSLSVLDI 576 S L A + L+L++N + +S NL IL + RN + V +L L I Sbjct: 46 DATLSTLKACKHLALSTNNIEKISSLSGMENLRILSLGRNLIKKIENLDAVADTLEELWI 105 Query: 577 THNKFICECELSTFINW--LNHTNVTIAG 603 ++N+ + +N L +N I Sbjct: 106 SYNQIASLSGIEKLVNLRVLYMSNNKITN 134 Score = 37.1 bits (84), Expect = 0.038, Method: Composition-based stats. Identities = 18/117 (15%), Positives = 40/117 (34%), Gaps = 10/117 (8%) Query: 112 PDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNS 171 L L L + ++ L L L +N I+ + + + Sbjct: 46 DATLSTLKACKHLALSTNNIEKI----SSLSGMENLRILSLGRNLIKKIENLDAVAD--T 99 Query: 172 LKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVL 228 L+ + S NQI + E + L ++ N + + +D ++ +++L Sbjct: 100 LEELWISYNQIASLSGIE----KLVNLRVLYMSNNKITNWGEIDKLAALDKLEDLLL 152 >3G04-C nrPDB Length = 239 Score = 61.7 bits (148), Expect = 1e-09, Method: Composition-based stats. Identities = 42/225 (18%), Positives = 83/225 (36%), Gaps = 22/225 (9%) Query: 307 VFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYN-LLGELYSSNFYGLPKVAYI 365 + + L L + I AF L N+ + +S + L +L S +FY L KV +I Sbjct: 26 IPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHI 85 Query: 366 DLQKNH-IAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLT 424 +++ + I K L L+ L + + L + + + Sbjct: 86 EIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFF------------ 133 Query: 425 ANLIHLSENRLENLDILYFLLRVPHLQI-LILNQNRFSSCSGDQTPSENPSLEQLFLGEN 483 ++ +++N + + + + L L N F+S G L+ ++L +N Sbjct: 134 --ILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNG--TKLDAVYLNKN 189 Query: 484 MLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTAL 528 + + V+ G S L ++ + +LP HL L Sbjct: 190 KYLTVIDKDAFGGVYSGPSL---LDVSQTSVTALPSKGLEHLKEL 231 Score = 52.1 bits (123), Expect = 9e-07, Method: Composition-based stats. Identities = 39/216 (18%), Positives = 83/216 (38%), Gaps = 22/216 (10%) Query: 41 VPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRIL 100 +P + +T+ L L ++RT+ + +F L + + + T ++ +F NL + + Sbjct: 26 IPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHI 85 Query: 101 DLGSS-KIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTR------LDLS 153 ++ ++ + ++ PDA + L L L ++ GL F +L + L+++ Sbjct: 86 EIRNTRNLTYIDPDALKELPLLKFLGIFNTGL-------KMFPDLTKVYSTDIFFILEIT 138 Query: 154 KNQIRSLYLHPSFGKL-NSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRV 212 N + +F L N ++ +N V + G L L N + + Sbjct: 139 DNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFN---GTKLDAVYLNKNKYLTVI 195 Query: 213 SVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSN 248 D + +LDVS T + + Sbjct: 196 DKDAFGGV----YSGPSLLDVSQTSVTALPSKGLEH 227 Score = 48.2 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 40/228 (17%), Positives = 71/228 (31%), Gaps = 25/228 (10%) Query: 360 PKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLP 419 P + L + H+ I F L ++ I+ + L + L Sbjct: 31 PSTQTLKLIETHLRTIPSHAFSNLPN----------ISRIYVSIDVTLQQLESHSFYNLS 80 Query: 420 KINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLF 479 K+ I + R L +P L+ L + L Sbjct: 81 KV----THIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILE 136 Query: 480 LGENMLQLAWETELCWDVFEGLSH-LQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRL 538 + +N + + F+GL + L L +N S+ F+ T L + LN N+ Sbjct: 137 ITDNPYMT----SIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNG-TKLDAVYLNKNKY 191 Query: 539 TVLSHNDLPANL----EILDISRNQLLAPNPDVFVSLSVLDITHNKFI 582 + D + +LD+S+ + A L L I N + Sbjct: 192 LTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKEL-IARNTWT 238 >1T3G-A nrPDB Length = 159 Score = 59.8 bits (143), Expect = 5e-09, Method: Composition-based stats. Identities = 28/161 (17%), Positives = 64/161 (39%), Gaps = 23/161 (14%) Query: 693 YDAYLCFSSKD-FTWVQN---------ALLKH-LDTQYSDQNRFNLCFEERDFVPGENRI 741 YDAYL ++ D W Q +L L+ Y + L +RD +P I Sbjct: 3 YDAYLSYTKVDPDQWNQETGEEERFALEILPDMLEKHY----GYKLFIPDRDLIPTGTYI 58 Query: 742 ANIQDAIWNSRKIVCLVSRHF-LRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQL 800 ++ + S++++ +++ ++ +R GW + L +I++ + Sbjct: 59 EDVARCVDQSKRLIIVMTPNYVVRRGWSIFELETRLRNMLVTGEIKVILI--ECSELRGI 116 Query: 801 MKHQSIRGF---VQKQQYLRW--PEDFQDVGWFLHKLSQQI 836 M +Q + ++ ++W P+ + F +L ++ Sbjct: 117 MNYQEVEALKHTIKLLTVIKWHGPKCNKLNSKFWKRLQYEM 157 >2Q4G-W nrPDB Length = 461 Score = 59.4 bits (142), Expect = 6e-09, Method: Composition-based stats. Identities = 69/456 (15%), Positives = 140/456 (30%), Gaps = 37/456 (8%) Query: 146 ALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPL--QGKTLSFFSL 203 + LD+ ++ L + + + ++ L+ +L Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNL 63 Query: 204 AANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGN--FSNAISKSQAFSLILA 261 +N L V + + +I +S + G S+ + + Sbjct: 64 RSNEL---GDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120 Query: 262 HHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAY 321 + G + + + L + + + LS L + V D K L ++ Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL-ASVLRAKPDFKELTVSN 179 Query: 322 NKINKIADEAF-YGLD----NLQVLNLSYNLLGELYSSNFYGL----PKVAYIDLQKNHI 372 N IN+ GL L+ L L + + G+ + + L N + Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239 Query: 373 AIIQD-----QTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANL 427 + +L+TL + D+ +L +++L N Sbjct: 240 GDVGMAELCPGLLHPSSRLRTLWI----WECGITAKGCGDLCRVLRAKESLKELSLAGNE 295 Query: 428 IHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQL 487 + RL +L ++ L + + ++N L +L + N L+ Sbjct: 296 LGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLED 355 Query: 488 AWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLT----ALRGLSLNSNRLTVLSH 543 A ELC + + S L+VL+L ++ + +LR L L++N L Sbjct: 356 AGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGI 415 Query: 544 NDLPAN-------LEILDISRNQLLAPNPDVFVSLS 572 L + LE L + D +L Sbjct: 416 LQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALE 451 Score = 57.9 bits (138), Expect = 2e-08, Method: Composition-based stats. Identities = 67/383 (17%), Positives = 133/383 (34%), Gaps = 37/383 (9%) Query: 229 EILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARS 288 +++ + G T + S+A+ + A + + G H + Q + + Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90 Query: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN-----KINKIADEAFYGLDNLQVLNL 343 S+++ L+ + S TL L+ L+L+ N + + + L+ L L Sbjct: 91 SLQNCCLTGAGC-GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQL 149 Query: 344 SYNLLGELYS----SNFYGLPKVAYIDLQKNHIAIIQDQTF-KFLE----KLQTLDLRDN 394 Y L S P + + N I + + L+ +L+ L L Sbjct: 150 EYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESC 209 Query: 395 ALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILI 454 +T+ + D+ +L ++ L +N + +L+ R+ L I Sbjct: 210 GVTSDNC----RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265 Query: 455 LNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYL 514 + SL++L L N L LC + E L+ L++ Sbjct: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325 Query: 515 NSLPPGVFSHLTA----LRGLSLNSNRLTVLSHNDL------PAN-LEILDISRNQLLAP 563 + FS + A L L +++NRL +L P + L +L ++ + Sbjct: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385 Query: 564 NPDVF-------VSLSVLDITHN 579 + SL LD+++N Sbjct: 386 SCSSLAATLLANHSLRELDLSNN 408 Score = 49.8 bits (117), Expect = 5e-06, Method: Composition-based stats. Identities = 48/250 (19%), Positives = 88/250 (35%), Gaps = 23/250 (9%) Query: 353 SSNFYGLPKVAYIDLQKNHIAIIQDQT-FKFL--EKLQTLDLRDNALTTIHFIPSIPDIF 409 SS P +A ++L+ N + + + L + L + Sbjct: 49 SSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSST 108 Query: 410 LSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTP 469 L L TL +++L+ NL+ + +L +L R+ LQ+ + + S Sbjct: 109 LR--TLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVL 166 Query: 470 SENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLP----PGVFSHL 525 P ++L + N + A LC + + L+ L L + S G+ + Sbjct: 167 RAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASK 226 Query: 526 TALRGLSLNSNRLTVLSHNDL-------PANLEILDISRNQLLAPNPDVF-------VSL 571 +LR L+L SN+L + +L + L L I + A SL Sbjct: 227 ASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESL 286 Query: 572 SVLDITHNKF 581 L + N+ Sbjct: 287 KELSLAGNEL 296 Score = 32.1 bits (71), Expect = 1.1, Method: Composition-based stats. Identities = 65/326 (19%), Positives = 105/326 (32%), Gaps = 31/326 (9%) Query: 38 LTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNL 97 L+ + L T + L LS N + L+ L L Q + L Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGD------AGLQLLCEGLLDPQCRLEKL---------QL 149 Query: 98 RILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDA---VLKDGYFRNLKALTRLDLSK 154 L ++ L + EL + +++A VL G + L L L Sbjct: 150 EYCSLSAASCEPLA-SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLES 208 Query: 155 NQIRSLY---LHPSFGKLNSLKSIDFSSNQIFLVCEHELEP-LQGKTLSFFSLAANSLYS 210 + S L SL+ + SN++ V EL P L + +L Sbjct: 209 CGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGI 268 Query: 211 RVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAF--SLILAHHIMGAG 268 C L+ L ++GN + + + SL + A Sbjct: 269 TAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAA 328 Query: 269 FGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIA 328 H QN F L + + L V L + + L+VL LA ++ + Sbjct: 329 CCSHFSSVLAQNRF--LLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSS 386 Query: 329 DEAFYG--LDN--LQVLNLSYNLLGE 350 + L N L+ L+LS N LG+ Sbjct: 387 CSSLAATLLANHSLRELDLSNNCLGD 412 >1OGQ-A nrPDB Length = 313 Score = 56.7 bits (135), Expect = 4e-08, Method: Composition-based stats. Identities = 50/252 (19%), Positives = 89/252 (35%), Gaps = 26/252 (10%) Query: 341 LNLSYNLLGELYS--SNFYGLPKVAYIDLQK-NHIAIIQDQTFKFLEKLQTLDLRDNALT 397 L+LS L + Y S+ LP + ++ + N++ L +L L + ++ Sbjct: 55 LDLSGLNLPKPYPIPSSLANLPYLNFLYIGGINNLVGPIPPAIAKLTQLHYLYITHTNVS 114 Query: 398 TIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQ 457 +IPD + TL ++ + N + + + + +P+L + + Sbjct: 115 -----GAIPDFLSQ---IKTLVTLDFSYNAL--------SGTLPPSISSLPNLVGITFDG 158 Query: 458 NRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSL 517 NR S D S + + + N L T F L +L + L+ N L Sbjct: 159 NRISGAIPDSYGSFSKLFTSMTISRNRL-----TGKIPPTFANL-NLAFVDLSRNMLEGD 212 Query: 518 PPGVFSHLTALRGLSLNSNRLTV-LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDI 576 +F + + L N L L L NL LD+ N++ P L L Sbjct: 213 ASVLFGSDKNTQKIHLAKNSLAFDLGKVGLSKNLNGLDLRNNRIYGTLPQGLTQLKFLHS 272 Query: 577 THNKFICECELS 588 + F C Sbjct: 273 LNVSFNNLCGEI 284 Score = 52.1 bits (123), Expect = 1e-06, Method: Composition-based stats. Identities = 46/250 (18%), Positives = 81/250 (32%), Gaps = 31/250 (12%) Query: 275 KDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYG 334 P ++ A L + ++ + V + + + L L L + + ++ + Sbjct: 65 PYPIPSSLANLPYLNFLYIGGINNLVGPIPPAIAK-LTQLHYLYITHTNVSGAIPDFLSQ 123 Query: 335 LDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDN 394 + L L+ SYN L + LP + I N I+ ++ KL Sbjct: 124 IKTLVTLDFSYNALSGTLPPSISSLPNLVGITFDGNRISGAIPDSYGSFSKL-------- 175 Query: 395 ALTTIHFIPSIPDIFLSGNKLVTLPK---INLTANLIHLSENRLENLDILYFLLRVPHLQ 451 + +S N+L NL + LS N LE D + Q Sbjct: 176 ----------FTSMTISRNRLTGKIPPTFANLNLAFVDLSRNMLEG-DASVLFGSDKNTQ 224 Query: 452 ILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNH 511 + L +N + + +L L L N + L L L L ++ Sbjct: 225 KIHLAKNSLA--FDLGKVGLSKNLNGLDLRNNRIYGTLPQGLT-----QLKFLHSLNVSF 277 Query: 512 NYLN-SLPPG 520 N L +P G Sbjct: 278 NNLCGEIPQG 287 Score = 49.8 bits (117), Expect = 5e-06, Method: Composition-based stats. Identities = 52/299 (17%), Positives = 94/299 (31%), Gaps = 37/299 (12%) Query: 76 ELGSQYT-PLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDA 134 +LG+ T + N L +L ++ Y ++ L L L Sbjct: 17 DLGNPTTLSSWLPTTDCCNRTWLGVLCDTDTQTYRVNN-----------LDLSGLNLPKP 65 Query: 135 VLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQ 194 NL L L + + P+ KL L + + + L Q Sbjct: 66 YPIPSSLANLPYLNFLYIGGINNLVGPIPPAIAKLTQLHYLYITHTNVSGAIPDFLS--Q 123 Query: 195 GKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQ 254 KTL + N+L + N GN + I ++ Sbjct: 124 IKTLVTLDFSYNALSGTLPPSISSLPNLVGIT------FDGNRISGAIPDSY-------- 169 Query: 255 AFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDL 314 + + + TFA L ++ +DLS + S +F + K+ Sbjct: 170 ---GSFSKLFTSMTISRNRLTGKIPPTFANL---NLAFVDLSRNMLEGDASVLFGSDKNT 223 Query: 315 KVLNLAYNKINKIADEAFYGLD-NLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHI 372 + ++LA N + D GL NL L+L N + L + +++ N++ Sbjct: 224 QKIHLAKNSLAF--DLGKVGLSKNLNGLDLRNNRIYGTLPQGLTQLKFLHSLNVSFNNL 280 Score = 45.9 bits (107), Expect = 7e-05, Method: Composition-based stats. Identities = 34/165 (20%), Positives = 63/165 (38%), Gaps = 11/165 (6%) Query: 426 NLIHLS-ENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENM 484 N + LS N + I L +P+L L + ++ L L++ Sbjct: 53 NNLDLSGLNLPKPYPIPSSLANLPYLNFLYIGGINNLVGPIPPAIAKLTQLHYLYITHT- 111 Query: 485 LQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVL--- 541 + D + L L ++N L+ P S L L G++ + NR++ Sbjct: 112 ----NVSGAIPDFLSQIKTLVTLDFSYNALSGTLPPSISSLPNLVGITFDGNRISGAIPD 167 Query: 542 SHNDLPANLEILDISRNQLLAPNPDVFVSLSV--LDITHNKFICE 584 S+ + ISRN+L P F +L++ +D++ N + Sbjct: 168 SYGSFSKLFTSMTISRNRLTGKIPPTFANLNLAFVDLSRNMLEGD 212 Score = 42.1 bits (97), Expect = 0.001, Method: Composition-based stats. Identities = 35/190 (18%), Positives = 68/190 (35%), Gaps = 14/190 (7%) Query: 41 VPQVLN---TTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNL 97 +P L+ T L S+N + S L L + I +++ + L Sbjct: 117 IPDFLSQIKTLVTLDFSYNALSGTLPPSISSLPNLVGITFDGNRISGAI-PDSYGSFSKL 175 Query: 98 RI-LDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQ 156 + + +++ P F L +L + L L F + K ++ L+KN Sbjct: 176 FTSMTISRNRLTGKIPPTFANL-NLAFVDLSRNMLEGDA--SVLFGSDKNTQKIHLAKNS 232 Query: 157 IRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDW 216 + + G +L +D +N+I+ L L K L +++ N+L + Sbjct: 233 L--AFDLGKVGLSKNLNGLDLRNNRIYGTLPQGLTQL--KFLHSLNVSFNNLC--GEIPQ 286 Query: 217 GKCMNPFRNM 226 G + F Sbjct: 287 GGNLQRFDVS 296 >5KH1-A nrPDB Length = 591 Score = 55.9 bits (133), Expect = 6e-08, Method: Composition-based stats. Identities = 53/247 (21%), Positives = 91/247 (36%), Gaps = 58/247 (23%) Query: 339 QVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLE-KLQTLDLRDNALT 397 L+LS L L P + I++ KN++++I L L L++ N L Sbjct: 70 TNLDLSELGLTTLPEIP----PGIKSINISKNNLSLI-----SPLPASLTQLNVSYNRLI 120 Query: 398 TIHFIP-SIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILN 456 + +P + + S N+L+TLP + ++ +H+S N+L +L +L L Sbjct: 121 ELPALPQGLKLLNASHNQLITLPTLPISLKELHVSNNQLCSLPVLPEL------------ 168 Query: 457 QNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNS 516 LE L + N L + LQ + N L+ Sbjct: 169 ------------------LETLDVSCNGLAVLPPLPF---------SLQEISAIGNLLSE 201 Query: 517 LPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFV--SLSVL 574 LPP + + + N LT + + LP NL NQ+ + + + Sbjct: 202 LPPLPHN----IHSIWAIDNMLTDIPY--LPENLRNGYFDINQISHIPESILNLRNECSI 255 Query: 575 DITHNKF 581 DI+ N Sbjct: 256 DISDNPL 262 Score = 45.9 bits (107), Expect = 7e-05, Method: Composition-based stats. Identities = 45/274 (16%), Positives = 83/274 (30%), Gaps = 38/274 (13%) Query: 21 IPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQ 80 + LT +P++ + + +S N + ++ L L + Sbjct: 62 VSCLQNQETNLDLSELGLTTLPEIPPGIKSINISKNNLSLISPLP----ASLTQLNVSYN 117 Query: 81 YTPLTIDKEAFRNLPN-LRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDG 139 LP L++L+ +++ L L EL + L + Sbjct: 118 RLIE------LPALPQGLKLLNASHNQLITLPTL----PISLKELHVSNNQLCSLPVLPE 167 Query: 140 YFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLS 199 L LD+S N + L P SL+ I N + EL PL + Sbjct: 168 L------LETLDVSCNGLAVLPPLPF-----SLQEISAIGNLLS-----ELPPLP-HNIH 210 Query: 200 FFSLAANSLYSRVSVDWGK-----CMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQ 254 N L + +N ++ IL++ N ++DI+ N ++ + Sbjct: 211 SIWAIDNMLTDIPYLPENLRNGYFDINQISHIPESILNLR-NECSIDISDNPLSSHALQS 269 Query: 255 AFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARS 288 L + G F LA + Sbjct: 270 LQRLTSSPDYHGPQIYFSMSDGQQNTLHRPLADA 303 Score = 39.0 bits (89), Expect = 0.009, Method: Composition-based stats. Identities = 29/175 (16%), Positives = 65/175 (37%), Gaps = 39/175 (22%) Query: 289 SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348 ++ L+ SH + +L + LK L+++ N++ + L L Sbjct: 128 GLKLLNASHNQLITLPTLPIS----LKELHVSNNQLCSLPV-----LPEL---------- 168 Query: 349 GELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPS-IPD 407 + +D+ N +A++ F LQ + N L+ + +P I Sbjct: 169 -------------LETLDVSCNGLAVLPPLPF----SLQEISAIGNLLSELPPLPHNIHS 211 Query: 408 IFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSS 462 I+ N L +P + + N++ ++ +L + + + ++ N SS Sbjct: 212 IWAIDNMLTDIPYLPENLRNGYFDINQISHIP--ESILNLRNECSIDISDNPLSS 264 >3CVR-A nrPDB Length = 571 Score = 55.2 bits (131), Expect = 1e-07, Method: Composition-based stats. Identities = 40/212 (18%), Positives = 77/212 (36%), Gaps = 22/212 (10%) Query: 196 KTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITG-NFSNAISKSQ 254 + FSL+ NS Y+ +S + + + + L V + N S+ Q Sbjct: 6 PINNNFSLSQNSFYNTISGTYADYFSAWDKWEKQALPGENRNEAVSLLKECLINQFSELQ 65 Query: 255 AFSLILAHHIMGAGFGFHNIKDPDQNTFAGLAR--SSVRHLDLSHGFVFSLNSRVFETLK 312 L L+ + + QN L +S+ +LD + +L E Sbjct: 66 LNRLNLSSLPDNLPPQIT-VLEITQNALISLPELPASLEYLDACDNRLSTLP----ELPA 120 Query: 313 DLKVLNLAYNKINKIADEAFYGLDN-LQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNH 371 LK L++ N++ + L L+ +N N L L + + ++ N Sbjct: 121 SLKHLDVDNNQLTMLP-----ELPALLEYINADNNQLTMLPELP----TSLEVLSVRNNQ 171 Query: 372 IAIIQDQTFKFLEKLQTLDLRDNALTTIHFIP 403 + + + E L+ LD+ N L ++ +P Sbjct: 172 LTFLPELP----ESLEALDVSTNLLESLPAVP 199 Score = 54.4 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 44/206 (21%), Positives = 77/206 (37%), Gaps = 34/206 (16%) Query: 345 YNLLGELYSSNFYGLPKVAYIDL---QKNHIAIIQDQT----FKFLEKLQTLDLRDNALT 397 YN + Y+ F K L +N + + F L +L L+L Sbjct: 19 YNTISGTYADYFSAWDKWEKQALPGENRNEAVSLLKECLINQFSEL-QLNRLNLSSLP-- 75 Query: 398 TIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQ 457 + P I + ++ N L++LP++ + + +NRL L L L+ L ++ Sbjct: 76 -DNLPPQITVLEITQNALISLPELPASLEYLDACDNRLSTLPELP-----ASLKHLDVDN 129 Query: 458 NRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSL 517 N+ + P LE + N L + E + L+VL + +N L L Sbjct: 130 NQLT-----MLPELPALLEYINADNNQLTMLPEL---------PTSLEVLSVRNNQLTFL 175 Query: 518 PPGVFSHLTALRGLSLNSNRLTVLSH 543 P +L L +++N L L Sbjct: 176 P----ELPESLEALDVSTNLLESLPA 197 Score = 45.9 bits (107), Expect = 7e-05, Method: Composition-based stats. Identities = 32/101 (31%), Positives = 48/101 (47%), Gaps = 6/101 (5%) Query: 506 VLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNP 565 L LN L+SLP + +T L + N L L +LPA+LE LD N+L P Sbjct: 63 ELQLNRLNLSSLPDNLPPQITVLE---ITQNALISLP--ELPASLEYLDACDNRLSTL-P 116 Query: 566 DVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPA 606 ++ SL LD+ +N+ EL + ++N N + P Sbjct: 117 ELPASLKHLDVDNNQLTMLPELPALLEYINADNNQLTMLPE 157 Score = 44.0 bits (102), Expect = 3e-04, Method: Composition-based stats. Identities = 31/181 (17%), Positives = 59/181 (32%), Gaps = 26/181 (14%) Query: 36 CNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLP 95 L +P++ + E L N + T+ L+ L++ + + LP Sbjct: 90 NALISLPELPASLEYLDACDNRLSTLPELP----ASLKHLDVDNNQLTM------LPELP 139 Query: 96 N-LRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSK 154 L ++ ++++ L L L + L+ ++L LD+S Sbjct: 140 ALLEYINADNNQLTMLPEL----PTSLEVLSVRNNQLTFLP------ELPESLEALDVST 189 Query: 155 NQIRSLY--LHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRV 212 N + SL + + N+I + E L L N L SR+ Sbjct: 190 NLLESLPAVPVRNHHSEETEIFFRCRENRITHIPE---NILSLDPTCTIILEDNPLSSRI 246 Query: 213 S 213 Sbjct: 247 R 247 Score = 36.7 bits (83), Expect = 0.042, Method: Composition-based stats. Identities = 23/174 (13%), Positives = 56/174 (32%), Gaps = 18/174 (10%) Query: 20 GIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGS 79 +P L+ +P++ + + L + N + + P L L+ + + Sbjct: 94 SLPELPASLEYLDACDNRLSTLPELPASLKHLDVDNNQLTMLPE--LPAL--LEYINADN 149 Query: 80 QYTPLTIDKEAFRNLP-NLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAV-LK 137 + LP +L +L + ++++ FL L L + L + Sbjct: 150 NQLTM------LPELPTSLEVLSVRNNQLTFLPEL----PESLEALDVSTNLLESLPAVP 199 Query: 138 DGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELE 191 + + +N+I ++ + L+ +I N + L Sbjct: 200 VRNHHSEETEIFFRCRENRIT--HIPENILSLDPTCTIILEDNPLSSRIRESLS 251 Score = 29.4 bits (64), Expect = 6.4, Method: Composition-based stats. Identities = 20/132 (15%), Positives = 39/132 (29%), Gaps = 7/132 (5%) Query: 19 FGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFP------FLEQL 72 +P + LT +P++ E + N + + QL Sbjct: 113 STLPELPASLKHLDVDNNQLTMLPELPALLEYINADNNQLTMLPELPTSLEVLSVRNNQL 172 Query: 73 QLL-ELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGL 131 L EL L + +LP + + + S + + H+ E L Sbjct: 173 TFLPELPESLEALDVSTNLLESLPAVPVRNHHSEETEIFFRCRENRITHIPENILSLDPT 232 Query: 132 SDAVLKDGYFRN 143 +L+D + Sbjct: 233 CTIILEDNPLSS 244 >2IFG-A nrPDB Length = 347 Score = 54.4 bits (129), Expect = 2e-07, Method: Composition-based stats. Identities = 34/184 (18%), Positives = 51/184 (27%), Gaps = 49/184 (26%) Query: 430 LSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAW 489 L R LD L+ L +L L + + L+ L L + Sbjct: 13 LRCTRDGALDSLHHLPGAENLTELYIENQQ--------------HLQHLELRD------- 51 Query: 490 ETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPAN 549 GL L+ L + + L + P F L L+L+ N L LS + Sbjct: 52 --------LRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGL 103 Query: 550 LEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIY 609 SL L ++ N C C L W + + Sbjct: 104 --------------------SLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCH 143 Query: 610 CVYP 613 P Sbjct: 144 GQGP 147 Score = 49.0 bits (115), Expect = 9e-06, Method: Composition-based stats. Identities = 27/145 (18%), Positives = 55/145 (37%), Gaps = 5/145 (3%) Query: 268 GFGFHNIKDPDQNTFAGLARS-SVRHLDLSHG-FVFSLNSRVFETLKDLKVLNLAYNKIN 325 G +D ++ L + ++ L + + + L R L +L+ L + + + Sbjct: 10 SSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLR 69 Query: 326 KIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEK 385 +A +AF+ L LNLS+N L L GL + + L N + ++L++ Sbjct: 70 FVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGL-SLQELVLSGNPLHC--SCALRWLQR 126 Query: 386 LQTLDLRDNALTTIHFIPSIPDIFL 410 + L + P + Sbjct: 127 WEEEGLGGVPEQKLQCHGQGPLAHM 151 Score = 44.4 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 28/92 (30%), Positives = 38/92 (41%), Gaps = 3/92 (3%) Query: 66 FPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELR 125 P E L L + +Q ++ R L LR L + S + F+ PDAF L L Sbjct: 27 LPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLN 86 Query: 126 LYFCGLSDAVLKDGYFRNLKALTRLDLSKNQI 157 L F L L + L +L L LS N + Sbjct: 87 LSFNAL--ESLSWKTVQGL-SLQELVLSGNPL 115 Score = 44.4 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 30/111 (27%), Positives = 44/111 (39%), Gaps = 10/111 (9%) Query: 89 EAFRNLP---NLRILDLGSS-KIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNL 144 ++ +LP NL L + + + L +GL L L + GL F Sbjct: 22 DSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVA--PDAFHFT 79 Query: 145 KALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQG 195 L+RL+LS N + SL G SL+ + S N + C L LQ Sbjct: 80 PRLSRLNLSFNALESLSWKTVQG--LSLQELVLSGNPLH--CSCALRWLQR 126 >6ICZ-o nrPDB Length = 255 Score = 53.6 bits (127), Expect = 4e-07, Method: Composition-based stats. Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 3/80 (3%) Query: 293 LDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELY 352 +D S + L+ F L+ LK L + N+I +I + L L L L+ N L EL Sbjct: 47 IDFSDNEIRKLDG--FPLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELG 104 Query: 353 SSN-FYGLPKVAYIDLQKNH 371 + L + Y+ + +N Sbjct: 105 DLDPLASLKSLTYLSILRNP 124 Score = 51.3 bits (121), Expect = 2e-06, Method: Composition-based stats. Identities = 29/148 (19%), Positives = 60/148 (40%), Gaps = 15/148 (10%) Query: 315 KVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAI 374 + L+L KI I + LD ++ S N + +L F L ++ + + N I Sbjct: 22 RELDLRGYKIPVIENLG-ATLDQFDAIDFSDNEIRKLDG--FPLLRRLKTLLVNNNRICR 78 Query: 375 IQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENR 434 I + + L L L L +N+L + + + L +L +++ N + Sbjct: 79 IGEGLDQALPCLTELILTNNSLVELGDLDPL-------ASLKSLTYLSILRNPV-----T 126 Query: 435 LENLDILYFLLRVPHLQILILNQNRFSS 462 + LY + +VP +++L + + Sbjct: 127 NKKHYRLYVIYKVPQVRVLDFQKVKLKE 154 Score = 45.5 bits (106), Expect = 9e-05, Method: Composition-based stats. Identities = 28/143 (19%), Positives = 54/143 (37%), Gaps = 7/143 (4%) Query: 49 ERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIY 108 L L I + L+Q ++ + F L L+ L + +++I Sbjct: 22 RELDLRGYKIPVIENLG-ATLDQFDAIDFSDNEIR---KLDGFPLLRRLKTLLVNNNRIC 77 Query: 109 FLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSF-- 166 + Q L L EL L L + +LK+LT L + +N + + + + Sbjct: 78 RIGEGLDQALPCLTELILTNNSLV-ELGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVI 136 Query: 167 GKLNSLKSIDFSSNQIFLVCEHE 189 K+ ++ +DF ++ E E Sbjct: 137 YKVPQVRVLDFQKVKLKERQEAE 159 Score = 38.6 bits (88), Expect = 0.011, Method: Composition-based stats. Identities = 18/111 (16%), Positives = 39/111 (35%), Gaps = 8/111 (7%) Query: 260 LAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNL 319 F + I+ D ++ L +++ + + + + L L L L Sbjct: 40 TLDQFDAIDFSDNEIRKLDGFPLLR----RLKTLLVNNNRICRIGEGLDQALPCLTELIL 95 Query: 320 AYNKINKIAD-EAFYGLDNLQVLNLSYN---LLGELYSSNFYGLPKVAYID 366 N + ++ D + L +L L++ N Y +P+V +D Sbjct: 96 TNNSLVELGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQVRVLD 146 Score = 36.3 bits (82), Expect = 0.064, Method: Composition-based stats. Identities = 21/80 (26%), Positives = 33/80 (41%), Gaps = 5/80 (6%) Query: 428 IHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQL 487 I S+N + LD L R+ L +N NR G+ P L +L L N L Sbjct: 47 IDFSDNEIRKLDGFPLLRRLKTLL---VNNNRICRI-GEGLDQALPCLTELILTNNSLVE 102 Query: 488 AWETELCWDVFEGLSHLQVL 507 + + + L++L +L Sbjct: 103 LGDLD-PLASLKSLTYLSIL 121 Score = 35.9 bits (81), Expect = 0.068, Method: Composition-based stats. Identities = 24/106 (22%), Positives = 40/106 (37%), Gaps = 8/106 (7%) Query: 123 ELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQI 182 EL L + + L +D S N+IR L F L LK++ ++N+I Sbjct: 23 ELDLRG---YKIPVIENLGATLDQFDAIDFSDNEIRKL---DGFPLLRRLKTLLVNNNRI 76 Query: 183 FLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVL 228 + E + L L+ L NSL +D + + + Sbjct: 77 CRIGEGLDQAL--PCLTELILTNNSLVELGDLDPLASLKSLTYLSI 120 Score = 33.6 bits (75), Expect = 0.35, Method: Composition-based stats. Identities = 26/143 (18%), Positives = 48/143 (33%), Gaps = 16/143 (11%) Query: 425 ANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENM 484 + L ++ ++ L L + + N G L+ L + N Sbjct: 21 DRELDLRGYKIPVIENLGATLD--QFDAIDFSDNEIRKLDG---FPLLRRLKTLLVNNNR 75 Query: 485 LQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPP-GVFSHLTALRGLSLNSNRLTVLSH 543 + + + + L L L L +N L L + L +L LS+ N +T H Sbjct: 76 I-----CRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNPVTNKKH 130 Query: 544 NDLP-----ANLEILDISRNQLL 561 L + +LD + +L Sbjct: 131 YRLYVIYKVPQVRVLDFQKVKLK 153 >6J5T-G nrPDB Length = 852 Score = 52.1 bits (123), Expect = 1e-06, Method: Composition-based stats. Identities = 50/273 (18%), Positives = 90/273 (32%), Gaps = 29/273 (10%) Query: 322 NKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAY---IDLQKNHIAIIQDQ 378 NK+N + F L+VL++S ++ S + + + + L H I + Sbjct: 545 NKLNSDLAKKFTDCKYLRVLDISKSIFDAPLSEILDEIASLQHLACLSLSNTHPLIQFPR 604 Query: 379 TFKFLEKLQTLDLRD-NALTTIH------------FIPSIPDIFLSGNKLVTLPKINLTA 425 + + L LQ LD L + + + + + +L K+ Sbjct: 605 SMEDLHNLQILDASYCQNLKQLQPCIVLFKKLLVLDMTNCGSLECFPKGIGSLVKL---E 661 Query: 426 NLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENML 485 L+ R N L + + +L+ L L+ R ++ S + + + N Sbjct: 662 VLLGFKPARSNNGCKLSEVKNLTNLRKLGLSLTRGDQIEEEELDSLINLSKLMSISINCY 721 Query: 486 QLAWETELC-WDVFEGLSHLQVLYLNHNYLNSLPPGVFSH-LTALRGLSLNSNRLTVLSH 543 + + D L L L S P + H L LR +S+ S L + Sbjct: 722 DSYGDDLITKIDALTPPHQLHELSLQFYPGKSSPSWLSPHKLPMLRYMSICSGNLVKMQ- 780 Query: 544 NDLPANLEILDISRNQLLAPNPDVFVSLSVLDI 576 N N + SLS LD+ Sbjct: 781 EPFWGN-------ENTHWRIEGLMLSSLSDLDM 806 Score = 47.9 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 46/278 (16%), Positives = 87/278 (31%), Gaps = 20/278 (7%) Query: 290 VRHLDLSHGFVFSLNSRVFETLKDLK---VLNLAYNKINKIADEAFYGLDNLQVLNLSYN 346 +R LD+S + S + + + L+ L+L+ + L NLQ+L+ SY Sbjct: 561 LRVLDISKSIFDAPLSEILDEIASLQHLACLSLSNTHPLIQFPRSMEDLHNLQILDASYC 620 Query: 347 LLGELYSSNFYGLPKVAYIDLQK-NHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSI 405 + K+ +D+ + L KL+ L L + Sbjct: 621 QNLKQLQPCIVLFKKLLVLDMTNCGSLECFPKGI-GSLVKLEVL------LGFKPARSNN 673 Query: 406 PDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSG 465 L L K+ L+ E E LD L L ++ + I + + Sbjct: 674 GCKLSEVKNLTNLRKLGLSLTRGDQIEE--EELDSLINLSKLMSISINCYDSYGDDLITK 731 Query: 466 DQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHL 525 + L +L L + + W L L+ + + L + + + Sbjct: 732 IDALTPPHQLHELSLQFYPGKSSPS----WLSPHKLPMLRYMSICSGNLVKMQEPFWGNE 787 Query: 526 TA---LRGLSLNSNRLTVLSHNDLPANLEILDISRNQL 560 + GL L+S + L ++ L Sbjct: 788 NTHWRIEGLMLSSLSDLDMDWEVLQQSMPYLRTVTANW 825 Score = 36.7 bits (83), Expect = 0.050, Method: Composition-based stats. Identities = 45/290 (15%), Positives = 76/290 (26%), Gaps = 47/290 (16%) Query: 28 GRIAFYRFCNLTQVPQV---------------LNTTERLLLSFNYIRTVTASSFPFLEQL 72 + ++ + + + L L LS + S L L Sbjct: 553 KKFTDCKYLRVLDISKSIFDAPLSEILDEIASLQHLACLSLSNTHPLIQFPRSMEDLHNL 612 Query: 73 QLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLS 132 Q+L+ L + L +LD+ + P L L L + S Sbjct: 613 QILDASY-CQNLKQLQPCIVLFKKLLVLDMTNCGSLECFPKGIGSLVKLEVLLGFKPARS 671 Query: 133 DAVLKDGYFRNLKALTRLDLS---KNQIRSLYLHP--SFGKLNS---------------- 171 + K +NL L +L LS +QI L + KL S Sbjct: 672 NNGCKLSEVKNLTNLRKLGLSLTRGDQIEEEELDSLINLSKLMSISINCYDSYGDDLITK 731 Query: 172 ---------LKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNP 222 L + L P + L + S+ + +L WG Sbjct: 732 IDALTPPHQLHELSLQFYPGKSSPSW-LSPHKLPMLRYMSICSGNLVKMQEPFWGNENTH 790 Query: 223 FRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFH 272 +R L + +S ++ + A GF Sbjct: 791 WRIEGLMLSSLSDLDMDWEVLQQSMPYLRTVTANWCPELESFAIEDVGFR 840 >4K17-A nrPDB Length = 669 Score = 51.7 bits (122), Expect = 1e-06, Method: Composition-based stats. Identities = 62/364 (17%), Positives = 119/364 (32%), Gaps = 46/364 (12%) Query: 67 PFLEQLQLLELGSQYTPLTIDKEAFRNLPN--LRILDLGSSKI-----YFLHPDAFQGLF 119 LE+L L G + A + PN L ++L + + L + Sbjct: 247 NRLEELVLENAGLRIDFAQKLAGALAHNPNSGLHTINLAGNSLEDRGVSSLSIQFAKLPK 306 Query: 120 HLFELRLYFCGLS----DAVLKDGYFRNLK--ALTRLDLSKNQIRSLYLHPSFGKL---N 170 L L L LS +++ + L LT LDLS N +R L + L N Sbjct: 307 GLKHLNLSKTSLSPKGVNSLCQSLSANPLTASTLTHLDLSGNALRGDDLSHMYNFLAQPN 366 Query: 171 SLKSIDFSSN--QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVL 228 ++ +D S+ + +VC L + L+ +L+ + R + F + L Sbjct: 367 TIVHLDLSNTECSLEMVCSALLRGC-LQCLAVLNLSRSVFSHRKGKEVPPSFKQFFSSSL 425 Query: 229 EILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHN------IKDPDQNTF 282 ++ ++ +G + K+ L H + G N ++ Sbjct: 426 ALIQINLSGTKLSPEPL------KALLLGLACNHSLKGVSLDLSNCELGHCLRSGGAQVL 479 Query: 283 AGLARS--SVRHLDLSHGFVFSLNSR---VFETLKDLKVLNLAYNKINKIADEAFYGLDN 337 G ++ LD+S + S S + ++ L L N N + + + Sbjct: 480 EGCIAEIHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKN-FNNMKSKNLTPV-- 536 Query: 338 LQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALT 397 L+ L ++ L ++ D + I L +D+ N + Sbjct: 537 ---LD----NLVQMIQDEDSPLQSLSLADSKLKAEVTIIINALGSNTSLTKVDISGNGMG 589 Query: 398 TIHF 401 + Sbjct: 590 DMGA 593 Score = 49.8 bits (117), Expect = 5e-06, Method: Composition-based stats. Identities = 59/342 (17%), Positives = 111/342 (32%), Gaps = 66/342 (19%) Query: 280 NTFAGLARSSVRHLDLSHGFVFSLNSRVF-----ETLKDLKVLNLAYNKINKIADEAF-- 332 A S + ++L+ + + K LK LNL+ ++ + Sbjct: 269 GALAHNPNSGLHTINLAGNSLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLCQ 328 Query: 333 ----YGL--DNLQVLNLSYNLLGELYSSNFYGL----PKVAYIDLQKN--HIAIIQDQTF 380 L L L+LS N L S+ Y + ++DL + ++ Sbjct: 329 SLSANPLTASTLTHLDLSGNALRGDDLSHMYNFLAQPNTIVHLDLSNTECSLEMVCSALL 388 Query: 381 KF-LEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLD 439 + L+ L L+L + + P + + L +INL+ LS L+ L Sbjct: 389 RGCLQCLAVLNLSRSVFSHRKGKEVPPSFKQFFSSSLALIQINLSGT--KLSPEPLKALL 446 Query: 440 ILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFE 499 + L L+ C L G + E Sbjct: 447 LGLACNHSLKGVSLDLSNCELGHC--------------LRSGGAQVLEGCIAE------- 485 Query: 500 GLSHLQVLYLNHNYLNSLPPGV---FSHLTALRGLSLNSN-------RLTVLSHNDLP-- 547 + ++ L ++ N L S + S +++ L+L N LT + N + Sbjct: 486 -IHNITSLDISDNGLESDLSTLIVWLSKNRSIQHLALGKNFNNMKSKNLTPVLDNLVQMI 544 Query: 548 ----ANLEILDISRNQLLAP------NPDVFVSLSVLDITHN 579 + L+ L ++ ++L A SL+ +DI+ N Sbjct: 545 QDEDSPLQSLSLADSKLKAEVTIIINALGSNTSLTKVDISGN 586 Score = 37.8 bits (86), Expect = 0.020, Method: Composition-based stats. Identities = 42/226 (18%), Positives = 74/226 (32%), Gaps = 29/226 (12%) Query: 380 FKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLD 439 + +L D L IP I + + L +L + + E L + Sbjct: 189 TQDTRELNLQDFSH--LEHRDLIPIIAALEYN-QWFTKLSSKDLKLS-TDVCEQILRVVS 244 Query: 440 ILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFE 499 L + L+ L + +G + N L + L N L+ + L + Sbjct: 245 RSNRLEEL-VLENAGLRIDFAQKLAGALAHNPNSGLHTINLAGNSLEDRGVSSLSIQFAK 303 Query: 500 GLSHLQVLYLNHNYLNSLPPGVFSH----------LTALRGLSLNSNRLTVLSHNDL--- 546 L+ L L+ L+ P GV S + L L L+ N L + + Sbjct: 304 LPKGLKHLNLSKTSLS--PKGVNSLCQSLSANPLTASTLTHLDLSGNALRGDDLSHMYNF 361 Query: 547 ---PANLEILDISRNQ------LLAPNPDVFVSLSVLDITHNKFIC 583 P + LD+S + A L+VL+++ + F Sbjct: 362 LAQPNTIVHLDLSNTECSLEMVCSALLRGCLQCLAVLNLSRSVFSH 407 Score = 34.8 bits (78), Expect = 0.16, Method: Composition-based stats. Identities = 60/326 (18%), Positives = 99/326 (30%), Gaps = 68/326 (20%) Query: 20 GIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIR---------------TVTAS 64 S S G + + +L+ P +T L LS N +R T+ Sbjct: 314 SKTSLSPKGVNSLCQ--SLSANPLTASTLTHLDLSGNALRGDDLSHMYNFLAQPNTIVHL 371 Query: 65 SFPF----------------LEQLQLLELGSQYTPLTIDKEA-------FRNLPNLRILD 101 L+ L +L L KE F + L ++ Sbjct: 372 DLSNTECSLEMVCSALLRGCLQCLAVLNLSRSVFSHRKGKEVPPSFKQFFSSSLALIQIN 431 Query: 102 LGSSKIYFLHPDA-FQGLF---HLFE--LRLYFCGLSDAVLKDGY------FRNLKALTR 149 L +K+ A GL L L L C L + G + +T Sbjct: 432 LSGTKLSPEPLKALLLGLACNHSLKGVSLDLSNCELGHCLRSGGAQVLEGCIAEIHNITS 491 Query: 150 LDLSKNQIRS--LYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPL----------QGKT 197 LD+S N + S L K S++ + N + L P+ + Sbjct: 492 LDISDNGLESDLSTLIVWLSKNRSIQHLALGKN-FNNMKSKNLTPVLDNLVQMIQDEDSP 550 Query: 198 LSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFS 257 L SLA + L + V++ N L +D+SGNG + A+ + Sbjct: 551 LQSLSLADSKLKAEVTIIINALG---SNTSLTKVDISGNGMGDMGAKMLAKALQINTKLR 607 Query: 258 LILAHHIMGAGFGFHNIKDPDQNTFA 283 ++ GF +I + + Sbjct: 608 TVIWDKNNITAQGFQDIAVAMEKNYT 633 >4PBW-B nrPDB Length = 283 Score = 49.4 bits (116), Expect = 7e-06, Method: Composition-based stats. Identities = 28/157 (17%), Positives = 51/157 (32%), Gaps = 29/157 (18%) Query: 454 ILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQL-----AWETELCWDVFEGLSHLQVLY 508 N + + S++ + N+ + L E + LQ L Sbjct: 22 DGNLFPLLEGQDSGSSNGQTSIQITDISRNITSIHIENWKNLQTLNAVDMELYTGLQRLT 81 Query: 509 LNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVF 568 + ++ L ++ P F+ LR + L+ NRLT LS +F Sbjct: 82 IRNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLSW----------------------QLF 119 Query: 569 VSLSVLDIT--HNKFICECELSTFINWLNHTNVTIAG 603 +L + D+ N F C C++ W + Sbjct: 120 QTLRLFDLRLERNPFQCSCDIRWIQLWQEKGEANLQS 156 Score = 48.6 bits (114), Expect = 1e-05, Method: Composition-based stats. Identities = 39/198 (19%), Positives = 64/198 (32%), Gaps = 13/198 (6%) Query: 320 AYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQT 379 + + + LQ L + + L + F P + YIDL N + + Q Sbjct: 59 NWKNLQTLNAVDMELYTGLQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLSWQL 118 Query: 380 FKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLD 439 F+ L L L L N I I G NL + +H NLD Sbjct: 119 FQTLR-LFDLRLERNPFQCSCDIRWIQLWQEKGE-------ANLQSQQLHCM-----NLD 165 Query: 440 ILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFE 499 LLR ++ L + S + EN + G + + W + Sbjct: 166 TAVILLRNMNITQCDLPEISVSHVNLTVREGENAVITCQGSGSPLPDVDWTVADLHSINT 225 Query: 500 GLSHLQVLYLNHNYLNSL 517 ++LQ ++ L + Sbjct: 226 HQTNLQWTNVHAIQLTLV 243 Score = 30.9 bits (68), Expect = 2.3, Method: Composition-based stats. Identities = 22/104 (21%), Positives = 39/104 (37%), Gaps = 7/104 (6%) Query: 54 SFNYIRTVTASSFPF-LEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHP 112 S N ++ + + + + + T +D E + L+ L + +S + + P Sbjct: 36 SSNGQTSIQITDISRNITSIHIENWKNLQTLNAVDMELY---TGLQRLTIRNSGLRNIQP 92 Query: 113 DAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQ 156 AF HL + L L L F+ L L L L +N Sbjct: 93 RAFAKNPHLRYIDLSGNRL--TTLSWQLFQTL-RLFDLRLERNP 133 Score = 29.4 bits (64), Expect = 7.6, Method: Composition-based stats. Identities = 12/61 (19%), Positives = 25/61 (40%), Gaps = 2/61 (3%) Query: 48 TERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKI 107 +RL + + +R + +F L+ ++L T+ + F+ L L L L + Sbjct: 77 LQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNRLT-TLSWQLFQTL-RLFDLRLERNPF 134 Query: 108 Y 108 Sbjct: 135 Q 135 >5UZB-A nrPDB Length = 177 Score = 49.4 bits (116), Expect = 7e-06, Method: Composition-based stats. Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 4/80 (5%) Query: 693 YDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSR 752 YD +C S +D Q+ L+ +L+ + RD PG ++ + A+ +S Sbjct: 42 YDVCVCHSEEDLVAAQD-LVSYLE---GSTASLRCFLQLRDATPGGAIVSELCQALSSSH 97 Query: 753 KIVCLVSRHFLRDGWCLEAF 772 V L++ FL+D WC Sbjct: 98 CRVLLITPGFLQDPWCKYQM 117 >4FZ5-A nrPDB Length = 154 Score = 49.4 bits (116), Expect = 7e-06, Method: Composition-based stats. Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 4/80 (5%) Query: 693 YDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSR 752 YD +C S +D Q+ L+ +L+ + RD PG ++ + A+ +S Sbjct: 19 YDVCVCHSEEDLVAAQD-LVSYLE---GSTASLRCFLQLRDATPGGAIVSELCQALSSSH 74 Query: 753 KIVCLVSRHFLRDGWCLEAF 772 V L++ FL+D WC Sbjct: 75 CRVLLITPGFLQDPWCKYQM 94 >3JB9-j nrPDB Length = 239 Score = 49.0 bits (115), Expect = 8e-06, Method: Composition-based stats. Identities = 43/228 (18%), Positives = 74/228 (32%), Gaps = 14/228 (6%) Query: 38 LTQVPQVLNTT--ERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDK-EAFRNL 94 L+QVP ++ L L + I + L L+ + +T I F + Sbjct: 8 LSQVPSFISPLKETELDLRWYQIPIIE-----NLGVLRDVHDAIDFTDNDIRYLGNFPRM 62 Query: 95 PNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSK 154 L+ L G+++I + PD + L +L L L L + + LT L Sbjct: 63 KRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHL-QEIADLDPLASCPQLTNLSCID 121 Query: 155 NQIRSLYLHPSFG--KLNSLKSIDFS--SNQIFLVCEHELEPLQGKTLSFFSLAANSLYS 210 N + + + ++ SL +DF L E +Q T S+ Sbjct: 122 NPVAQKQYYRLYLIWRIPSLHILDFERVRRNERLRAEEVFGQIQNPTEIASSI-MGVKSR 180 Query: 211 RVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSL 258 + +P N + I NA S ++ L Sbjct: 181 VFDLAALVQSHPEANSPITTGYTLTPEEREKIKEAIKNASSIAEINRL 228 Score = 47.1 bits (110), Expect = 3e-05, Method: Composition-based stats. Identities = 25/104 (24%), Positives = 43/104 (41%), Gaps = 6/104 (5%) Query: 293 LDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELY 352 +D + + L + F +K L+ L N+I IA + L NL+ L+L+ N L E+ Sbjct: 46 IDFTDNDIRYLGN--FPRMKRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIA 103 Query: 353 SSN-FYGLPKVAYIDLQKNHIAIIQDQTFK---FLEKLQTLDLR 392 + P++ + N +A Q + L LD Sbjct: 104 DLDPLASCPQLTNLSCIDNPVAQKQYYRLYLIWRIPSLHILDFE 147 Score = 41.7 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 33/176 (18%), Positives = 68/176 (38%), Gaps = 20/176 (11%) Query: 293 LDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQ----VLNLSYNLL 348 + L+ F+ + S + LK+ + L+L + +I I + L L+ ++ + N + Sbjct: 1 MRLNAEFLSQVPSFI-SPLKETE-LDLRWYQIPIIEN-----LGVLRDVHDAIDFTDNDI 53 Query: 349 GELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFI------ 402 L NF + ++ + N I I K L L+TL L N L I + Sbjct: 54 RYL--GNFPRMKRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIADLDPLASC 111 Query: 403 PSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQN 458 P + ++ N + L + + + + + + R+ ++ QN Sbjct: 112 PQLTNLSCIDNPVAQKQYYRLYL-IWRIPSLHILDFERVRRNERLRAEEVFGQIQN 166 Score = 38.6 bits (88), Expect = 0.013, Method: Composition-based stats. Identities = 20/99 (20%), Positives = 40/99 (40%), Gaps = 5/99 (5%) Query: 273 NIKDPDQNTFAGLARS-SVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIAD-E 330 + D D R ++ L + + ++ + + L +LK L+LA N + +IAD + Sbjct: 47 DFTDNDIRYLGNFPRMKRLQTLLCGNNRITAIAPDIGKVLPNLKTLSLAQNHLQEIADLD 106 Query: 331 AFYGLDNLQVLNLSYNLLGELYSSNFY---GLPKVAYID 366 L L+ N + + Y +P + +D Sbjct: 107 PLASCPQLTNLSCIDNPVAQKQYYRLYLIWRIPSLHILD 145 Score = 38.2 bits (87), Expect = 0.014, Method: Composition-based stats. Identities = 20/103 (19%), Positives = 34/103 (33%), Gaps = 9/103 (8%) Query: 451 QILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLN 510 L L + +L L + + F + LQ L Sbjct: 21 TELDLRWYQIPIIE---------NLGVLRDVHDAIDFTDNDIRYLGNFPRMKRLQTLLCG 71 Query: 511 HNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEIL 553 +N + ++ P + L L+ LSL N L ++ D A+ L Sbjct: 72 NNRITAIAPDIGKVLPNLKTLSLAQNHLQEIADLDPLASCPQL 114 Score = 31.7 bits (70), Expect = 1.4, Method: Composition-based stats. Identities = 25/131 (19%), Positives = 44/131 (33%), Gaps = 9/131 (6%) Query: 387 QTLDLRDNALTTIHFIPSIPD----IFLSGNKLVTLPKINLTANL--IHLSENRLENLDI 440 LDLR + I + + D I + N + L L + NR+ + Sbjct: 21 TELDLRWYQIPIIENLGVLRDVHDAIDFTDNDIRYLGNFPRMKRLQTLLCGNNRITAIAP 80 Query: 441 LYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEG 500 + +P+L+ L L QN + + P L L +N + L + Sbjct: 81 DIGKV-LPNLKTLSLAQNHLQEIADLDPLASCPQLTNLSCIDNPVAQKQYYRLY--LIWR 137 Query: 501 LSHLQVLYLNH 511 + L +L Sbjct: 138 IPSLHILDFER 148 >4PBV-A nrPDB Length = 268 Score = 48.6 bits (114), Expect = 1e-05, Method: Composition-based stats. Identities = 40/220 (18%), Positives = 68/220 (30%), Gaps = 15/220 (6%) Query: 298 GFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFY 357 L + + + + + + LQ L + + L + F Sbjct: 24 NLFPLLEGQDSRNITSIH--IENWKNLQTLNAVDMELYTGLQRLTIRNSGLRNIQPRAFA 81 Query: 358 GLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVT 417 P + YIDL N + + Q F+ L L L L N I I G Sbjct: 82 KNPHLRYIDLSGNRLTTLSWQLFQTLR-LFDLRLERNPFQCSCDIRWIQLWQEKGE---- 136 Query: 418 LPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQ 477 NL + +H NLD LLR ++ L + S + EN + Sbjct: 137 ---ANLQSQQLHCM-----NLDTAVILLRNMNITQCDLPEISVSHVNLTVREGENAVITC 188 Query: 478 LFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSL 517 G + + W + ++LQ ++ L + Sbjct: 189 QGSGSPLPDVDWTVADLHSINTHQTNLQWTNVHAIQLTLV 228 Score = 47.9 bits (112), Expect = 2e-05, Method: Composition-based stats. Identities = 24/108 (22%), Positives = 40/108 (37%), Gaps = 24/108 (22%) Query: 498 FEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISR 557 E + LQ L + ++ L ++ P F+ LR + L+ NRLT LS Sbjct: 56 MELYTGLQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLSW-------------- 101 Query: 558 NQLLAPNPDVFVSLSVLDIT--HNKFICECELSTFINWLNHTNVTIAG 603 +F +L + D+ N F C C++ W + Sbjct: 102 --------QLFQTLRLFDLRLERNPFQCSCDIRWIQLWQEKGEANLQS 141 Score = 45.9 bits (107), Expect = 7e-05, Method: Composition-based stats. Identities = 18/87 (20%), Positives = 38/87 (43%), Gaps = 2/87 (2%) Query: 289 SVRHLDLSH-GFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNL 347 ++ + + + + +LN+ E L+ L + + + I AF +L+ ++LS N Sbjct: 36 NITSIHIENWKNLQTLNAVDMELYTGLQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNR 95 Query: 348 LGELYSSNFYGLPKVAYIDLQKNHIAI 374 L L F L + + L++N Sbjct: 96 LTTLSWQLFQTLR-LFDLRLERNPFQC 121 Score = 32.5 bits (72), Expect = 0.77, Method: Composition-based stats. Identities = 12/66 (18%), Positives = 29/66 (43%), Gaps = 1/66 (1%) Query: 288 SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNL 347 + ++ L + + + ++ R F L+ ++L+ N++ ++ + F L L L L N Sbjct: 60 TGLQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNRLTTLSWQLFQTL-RLFDLRLERNP 118 Query: 348 LGELYS 353 Sbjct: 119 FQCSCD 124 Score = 32.1 bits (71), Expect = 1.2, Method: Composition-based stats. Identities = 21/102 (20%), Positives = 36/102 (35%), Gaps = 6/102 (5%) Query: 55 FNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDA 114 N + + + + + T +D E + L+ L + +S + + P A Sbjct: 23 GNLFPLLEGQDSRNITSIHIENWKNLQTLNAVDMELY---TGLQRLTIRNSGLRNIQPRA 79 Query: 115 FQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQ 156 F HL + L L L F+ L L L L +N Sbjct: 80 FAKNPHLRYIDLSGNRL--TTLSWQLFQTL-RLFDLRLERNP 118 Score = 29.0 bits (63), Expect = 8.4, Method: Composition-based stats. Identities = 12/61 (19%), Positives = 25/61 (40%), Gaps = 2/61 (3%) Query: 48 TERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKI 107 +RL + + +R + +F L+ ++L T+ + F+ L L L L + Sbjct: 62 LQRLTIRNSGLRNIQPRAFAKNPHLRYIDLSGNRLT-TLSWQLFQTL-RLFDLRLERNPF 119 Query: 108 Y 108 Sbjct: 120 Q 120 >1DCE-A nrPDB Length = 567 Score = 46.7 bits (109), Expect = 4e-05, Method: Composition-based stats. Identities = 28/104 (26%), Positives = 48/104 (46%), Gaps = 7/104 (6%) Query: 290 VRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLG 349 V HLDLSH + +L L+ L+VL + N + + A L LQ L L N L Sbjct: 465 VTHLDLSHNRLRALP-PALAALRCLEVLQASDNALENVDGVA--NLPRLQELLLCNNRLQ 521 Query: 350 ELYSSN-FYGLPKVAYIDLQKNHI---AIIQDQTFKFLEKLQTL 389 + + P++ ++LQ N + IQ++ + L + ++ Sbjct: 522 QSAAIQPLVSCPRLVLLNLQGNSLCQEEGIQERLAEMLPSVSSI 565 Score = 43.2 bits (100), Expect = 5e-04, Method: Composition-based stats. Identities = 22/114 (19%), Positives = 39/114 (34%), Gaps = 8/114 (7%) Query: 69 LEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYF 128 +++L L + + E L + LDL +++ L P A L L L+ Sbjct: 440 YADVRVLHLAHKDLTVLCHLE---QLLLVTHLDLSHNRLRALPP-ALAALRCLEVLQASD 495 Query: 129 CGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQI 182 L + NL L L L N+++ L ++ N + Sbjct: 496 NALENV----DGVANLPRLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGNSL 545 Score = 40.9 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 33/145 (22%), Positives = 54/145 (37%), Gaps = 5/145 (3%) Query: 441 LYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEG 500 L L+ + + + + EN L+ + +L LA + E Sbjct: 402 KETLQYFSTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYADVRVLHLAHKDLTVLCHLEQ 461 Query: 501 LSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQL 560 L + L L+HN L +LPP + L L L + N L + L+ L + N+L Sbjct: 462 LLLVTHLDLSHNRLRALPP-ALAALRCLEVLQASDNALENVDGVANLPRLQELLLCNNRL 520 Query: 561 L---APNPDV-FVSLSVLDITHNKF 581 A P V L +L++ N Sbjct: 521 QQSAAIQPLVSCPRLVLLNLQGNSL 545 Score = 40.5 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 25/103 (24%), Positives = 41/103 (39%), Gaps = 3/103 (2%) Query: 386 LQTLDLRDNALT---TIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILY 442 ++ L L LT + + + + LS N+L LP + + + L+ + Sbjct: 443 VRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNALENVD 502 Query: 443 FLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENML 485 + +P LQ L+L NR + Q P L L L N L Sbjct: 503 GVANLPRLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGNSL 545 Score = 38.6 bits (88), Expect = 0.011, Method: Composition-based stats. Identities = 20/90 (22%), Positives = 33/90 (36%), Gaps = 5/90 (5%) Query: 43 QVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDL 102 + L L LS N +R + + L L+ LE+ + + NLP L+ L L Sbjct: 460 EQLLLVTHLDLSHNRLRALPPA----LAALRCLEVLQASDNALENVDGVANLPRLQELLL 515 Query: 103 GSSKIYFLHPDA-FQGLFHLFELRLYFCGL 131 ++++ L L L L Sbjct: 516 CNNRLQQSAAIQPLVSCPRLVLLNLQGNSL 545 Score = 35.9 bits (81), Expect = 0.081, Method: Composition-based stats. Identities = 16/81 (19%), Positives = 28/81 (34%), Gaps = 5/81 (6%) Query: 32 FYRFCNLTQVPQVLNTTERLLL---SFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDK 88 L +P L L + S N + V L +LQ L L + + Sbjct: 469 DLSHNRLRALPPALAALRCLEVLQASDNALENV--DGVANLPRLQELLLCNNRLQQSAAI 526 Query: 89 EAFRNLPNLRILDLGSSKIYF 109 + + P L +L+L + + Sbjct: 527 QPLVSCPRLVLLNLQGNSLCQ 547 >5KU7-A nrPDB Length = 177 Score = 41.7 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 21/81 (25%), Positives = 31/81 (38%), Gaps = 7/81 (8%) Query: 693 YDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNL-CFEERDFVPGENRIANIQDAIWNS 751 YD +L F +D + D YS R + F + GE + AI S Sbjct: 8 YDVFLSFRGEDTRY------NFTDHLYSALGRRGIRTFRDDRLRRGEAIAPELLKAIEES 61 Query: 752 RKIVCLVSRHFLRDGWCLEAF 772 R V + S ++ WCL+ Sbjct: 62 RSSVIVFSENYAHSRWCLDEL 82 >4WYK-A nrPDB Length = 461 Score = 41.7 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 3/68 (4%) Query: 142 RNLKALTRLDLSKNQIRSL-YLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSF 200 N+ L L+LS N++ L + K +LK ++ S N++ E EL+ ++G L Sbjct: 168 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELK--SERELDKIKGLKLEE 225 Query: 201 FSLAANSL 208 L NSL Sbjct: 226 LWLDGNSL 233 Score = 41.3 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 33/138 (23%), Positives = 48/138 (34%), Gaps = 16/138 (11%) Query: 273 NIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKV-LNLAYNKINKIADEA 331 N P L V L L S+ LK L+ +L I+ + + Sbjct: 98 NSSAPPHTILNELKPEQVEQLKLIMSK-RYDGSQQALDLKGLRSDPDLVAQNIDVVLNRR 156 Query: 332 F----------YGLDNLQVLNLSYNLLGELY--SSNFYGLPKVAYIDLQKNHIAIIQD-Q 378 + L LNLS N L L SS P + ++L N + ++ Sbjct: 157 SCMAATLRIIEENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELD 216 Query: 379 TFKFLEKLQTLDLRDNAL 396 K L KL+ L L N+L Sbjct: 217 KIKGL-KLEELWLDGNSL 233 Score = 41.3 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 37/244 (15%), Positives = 79/244 (32%), Gaps = 29/244 (11%) Query: 270 GFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAY-NKINKIA 328 D +T + L + + LD + + + + L L ++ I Sbjct: 63 TRAQFFVEDASTASALKAVNYKILDRENRRISIIINSSAPPHTILNELKPEQVEQLKLIM 122 Query: 329 DEAFYGLDN---LQVL----NLSYNLLGELYSSNF----------YGLPKVAYIDLQKNH 371 + + G L+ L +L + + + +P++ ++L N Sbjct: 123 SKRYDGSQQALDLKGLRSDPDLVAQNIDVVLNRRSCMAATLRIIEENIPELLSLNLSNNR 182 Query: 372 IAIIQD--QTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIH 429 + + D + L+ L+L N L + + L K + L ++ L N + Sbjct: 183 LYRLDDMSSIVQKAPNLKILNLSGNELKS--------ERELDKIKGLKLEELWLDGNSL- 233 Query: 430 LSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAW 489 R ++ I R P L L ++ + P+ P + + G L+ Sbjct: 234 CDTFRDQSTYISAIRERFPKLLRLDGHELPPPIAFDVEAPTTLPPCKGSYFGTENLKSLV 293 Query: 490 ETEL 493 L Sbjct: 294 LHFL 297 Score = 40.9 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 39/171 (22%), Positives = 63/171 (36%), Gaps = 12/171 (7%) Query: 352 YSSNFYGLPKVAY--IDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIF 409 +S L V Y +D + I+II + + L L + + D Sbjct: 71 DASTASALKAVNYKILDRENRRISIIINSSAPPHTILNELKPEQVEQLKL-IMSKRYDGS 129 Query: 410 LSGNKLVTLPK-INLTANLIHLSENRLENLDILYFLL--RVPHLQILILNQNRFSSCSG- 465 L L +L A I + NR + ++ +P L L L+ NR Sbjct: 130 QQALDLKGLRSDPDLVAQNIDVVLNRRSCMAATLRIIEENIPELLSLNLSNNRLYRLDDM 189 Query: 466 DQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNS 516 + P+L+ L L N L+ +E D +GL L+ L+L+ N L Sbjct: 190 SSIVQKAPNLKILNLSGNELK----SERELDKIKGL-KLEELWLDGNSLCD 235 Score = 37.8 bits (86), Expect = 0.018, Method: Composition-based stats. Identities = 28/157 (17%), Positives = 57/157 (36%), Gaps = 8/157 (5%) Query: 385 KLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFL 444 + LD + ++ I + P L+ K + ++ L + + + +L L Sbjct: 82 NYKILDRENRRISIIINSSAPPHTILNELKPEQVEQLKLIMSKRYDGSQQALDLKGLRSD 141 Query: 445 LRV-PHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSH 503 + ++LN+ + + P L L L N L + + + + Sbjct: 142 PDLVAQNIDVVLNRRSCMAATLRIIEENIPELLSLNLSNNRLYRLDDMS---SIVQKAPN 198 Query: 504 LQVLYLNHNYLNSLPPGVFSHLTALR--GLSLNSNRL 538 L++L L+ N L S + L+ L L+ N L Sbjct: 199 LKILNLSGNELKS--ERELDKIKGLKLEELWLDGNSL 233 Score = 34.8 bits (78), Expect = 0.15, Method: Composition-based stats. Identities = 18/66 (27%), Positives = 26/66 (39%), Gaps = 4/66 (6%) Query: 499 EGLSHLQVLYLNHNYLNSLPP--GVFSHLTALRGLSLNSNRLTVLSHNDLPAN--LEILD 554 E + L L L++N L L + L+ L+L+ N L D LE L Sbjct: 168 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELW 227 Query: 555 ISRNQL 560 + N L Sbjct: 228 LDGNSL 233 Score = 34.4 bits (77), Expect = 0.20, Method: Composition-based stats. Identities = 13/66 (19%), Positives = 22/66 (33%), Gaps = 1/66 (1%) Query: 117 GLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSID 176 + L L L L + L L+LS N+++S L L+ + Sbjct: 169 NIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGL-KLEELW 227 Query: 177 FSSNQI 182 N + Sbjct: 228 LDGNSL 233 Score = 33.6 bits (75), Expect = 0.37, Method: Composition-based stats. Identities = 22/91 (24%), Positives = 33/91 (36%), Gaps = 8/91 (8%) Query: 68 FLEQLQLLELGSQYT-PLTIDKEAFRNLPNLRILDLGSSKIYFLHP-DAFQGLFHLFELR 125 + +L L L + L + PNL+IL+L +++ D +GL L EL Sbjct: 169 NIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLK-LEELW 227 Query: 126 LYFCGL-----SDAVLKDGYFRNLKALTRLD 151 L L + L RLD Sbjct: 228 LDGNSLCDTFRDQSTYISAIRERFPKLLRLD 258 Score = 31.7 bits (70), Expect = 1.3, Method: Composition-based stats. Identities = 17/66 (25%), Positives = 30/66 (45%), Gaps = 7/66 (10%) Query: 523 SHLTALRGLSLNSNRLTVLSHNDL----PANLEILDISRNQLLA---PNPDVFVSLSVLD 575 ++ L L+L++NRL L NL+IL++S N+L + + + L L Sbjct: 168 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELW 227 Query: 576 ITHNKF 581 + N Sbjct: 228 LDGNSL 233 >1KOH-A nrPDB Length = 277 Score = 41.3 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 33/139 (23%), Positives = 49/139 (35%), Gaps = 16/139 (11%) Query: 273 NIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKV-LNLAYNKINKIADEA 331 N P L V L L S+ LK L+ +L I+ + + Sbjct: 97 NSSAPPHTILNELKPEQVEQLKLIMSK-RYDGSQQALDLKGLRSDPDLVAQNIDVVLNRR 155 Query: 332 F----------YGLDNLQVLNLSYNLLGELY--SSNFYGLPKVAYIDLQKNHIAIIQD-Q 378 + L LNLS N L L SS P + ++L N + ++ Sbjct: 156 SSMAATLRIIEENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELD 215 Query: 379 TFKFLEKLQTLDLRDNALT 397 K L KL+ L L N+L+ Sbjct: 216 KIKGL-KLEELWLDGNSLS 233 Score = 40.5 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 39/171 (22%), Positives = 65/171 (38%), Gaps = 12/171 (7%) Query: 352 YSSNFYGLPKVAY--IDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIF 409 +S L V Y +D + I+II + + L L + + D Sbjct: 70 DASTASALKAVNYKILDRENRRISIIINSSAPPHTILNELKPEQVEQLKL-IMSKRYDGS 128 Query: 410 LSGNKLVTLPK-INLTANLIHLSENRLENLDILYFLL--RVPHLQILILNQNRFSSCSG- 465 L L +L A I + NR ++ ++ +P L L L+ NR Sbjct: 129 QQALDLKGLRSDPDLVAQNIDVVLNRRSSMAATLRIIEENIPELLSLNLSNNRLYRLDDM 188 Query: 466 DQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNS 516 + P+L+ L L N L+ +E D +GL L+ L+L+ N L+ Sbjct: 189 SSIVQKAPNLKILNLSGNELK----SERELDKIKGL-KLEELWLDGNSLSD 234 Score = 40.5 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 33/207 (15%), Positives = 69/207 (33%), Gaps = 33/207 (15%) Query: 270 GFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAY-NKINKIA 328 D +T + L + + LD + + + + L L ++ I Sbjct: 62 TRAQFFVEDASTASALKAVNYKILDRENRRISIIINSSAPPHTILNELKPEQVEQLKLIM 121 Query: 329 DEAFYGLDNLQVLNLSY----------------NLLGELYSSNF---YGLPKVAYIDLQK 369 + + G + Q L+L N + ++ +P++ ++L Sbjct: 122 SKRYDG--SQQALDLKGLRSDPDLVAQNIDVVLNRRSSMAATLRIIEENIPELLSLNLSN 179 Query: 370 NHIAIIQD--QTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANL 427 N + + D + L+ L+L N L + + L K + L ++ L N Sbjct: 180 NRLYRLDDMSSIVQKAPNLKILNLSGNELKS--------ERELDKIKGLKLEELWLDGNS 231 Query: 428 IHLSENRLENLDILYFLLRVPHLQILI 454 + + R ++ I R P L L Sbjct: 232 LSDTF-RDQSTYISAIRERFPKLLRLD 257 Score = 37.8 bits (86), Expect = 0.022, Method: Composition-based stats. Identities = 31/159 (19%), Positives = 59/159 (37%), Gaps = 10/159 (6%) Query: 385 KLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFL 444 + LD + ++ I + P L+ K + ++ L + + + +L L Sbjct: 81 NYKILDRENRRISIIINSSAPPHTILNELKPEQVEQLKLIMSKRYDGSQQALDLKGLRSD 140 Query: 445 LRVPHLQILILNQNRFSSCSGDQ--TPSENPSLEQLFLGENMLQLAWETELCWDVFEGLS 502 + Q + + NR SS + P L L L N L + + + Sbjct: 141 PDL-VAQNIDVVLNRRSSMAATLRIIEENIPELLSLNLSNNRLYRLDDMS---SIVQKAP 196 Query: 503 HLQVLYLNHNYLNSLPPGVFSHLTALR--GLSLNSNRLT 539 +L++L L+ N L S + L+ L L+ N L+ Sbjct: 197 NLKILNLSGNELKS--ERELDKIKGLKLEELWLDGNSLS 233 Score = 35.1 bits (79), Expect = 0.13, Method: Composition-based stats. Identities = 13/73 (17%), Positives = 23/73 (31%), Gaps = 1/73 (1%) Query: 117 GLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSID 176 + L L L L + L L+LS N+++S L L+ + Sbjct: 168 NIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGL-KLEELW 226 Query: 177 FSSNQIFLVCEHE 189 N + + Sbjct: 227 LDGNSLSDTFRDQ 239 Score = 34.8 bits (78), Expect = 0.16, Method: Composition-based stats. Identities = 18/67 (26%), Positives = 26/67 (38%), Gaps = 4/67 (5%) Query: 499 EGLSHLQVLYLNHNYLNSLPP--GVFSHLTALRGLSLNSNRLTVLSHNDLPAN--LEILD 554 E + L L L++N L L + L+ L+L+ N L D LE L Sbjct: 167 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELW 226 Query: 555 ISRNQLL 561 + N L Sbjct: 227 LDGNSLS 233 Score = 34.0 bits (76), Expect = 0.26, Method: Composition-based stats. Identities = 24/91 (26%), Positives = 35/91 (38%), Gaps = 8/91 (8%) Query: 68 FLEQLQLLELGSQYT-PLTIDKEAFRNLPNLRILDLGSSKIYFLHP-DAFQGLFHLFELR 125 + +L L L + L + PNL+IL+L +++ D +GL L EL Sbjct: 168 NIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLK-LEELW 226 Query: 126 LYFCGLSD-----AVLKDGYFRNLKALTRLD 151 L LSD + L RLD Sbjct: 227 LDGNSLSDTFRDQSTYISAIRERFPKLLRLD 257 Score = 31.3 bits (69), Expect = 1.7, Method: Composition-based stats. Identities = 17/66 (25%), Positives = 30/66 (45%), Gaps = 7/66 (10%) Query: 523 SHLTALRGLSLNSNRLTVLSHNDL----PANLEILDISRNQLLA---PNPDVFVSLSVLD 575 ++ L L+L++NRL L NL+IL++S N+L + + + L L Sbjct: 167 ENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELW 226 Query: 576 ITHNKF 581 + N Sbjct: 227 LDGNSL 232 Score = 29.4 bits (64), Expect = 7.5, Method: Composition-based stats. Identities = 24/112 (21%), Positives = 45/112 (40%), Gaps = 10/112 (8%) Query: 132 SDAVLKDGYFRNLKAL--TRLDLSKNQIRSL--YLHPSFGKLNSLKSIDFSSNQIFLVCE 187 S L R+ L +D+ N+ S+ L + L S++ S+N+++ + + Sbjct: 128 SQQALDLKGLRSDPDLVAQNIDVVLNRRSSMAATLRIIEENIPELLSLNLSNNRLYRLDD 187 Query: 188 HELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWT 239 + L +L+ N L S +D K + LE L + GN + Sbjct: 188 MSSIVQKAPNLKILNLSGNELKSERELDKIKGLK------LEELWLDGNSLS 233 >2CA6-A nrPDB Length = 386 Score = 41.3 bits (95), Expect = 0.002, Method: Composition-based stats. Identities = 47/228 (20%), Positives = 75/228 (32%), Gaps = 33/228 (14%) Query: 311 LKDLKVLNLAYNKINKIADEAFYGL-------DNLQVLNLSYNLLG-ELYSSNFYGL--- 359 L + L+ N A L L+ L L N LG + + L Sbjct: 93 CPKLHTVRLSDNAF---GPTAQEPLIDFLSKHTPLEHLYLHNNGLGPQAGAKIARALQEL 149 Query: 360 ---------PKVAYIDLQKNHIAIIQ----DQTFKFLEKLQTLDLRDNALTTIHFIPSIP 406 P + I +N + +TF+ L T+ + N + I Sbjct: 150 AVNKKAKNAPPLRSIICGRNRLENGSMKEWAKTFQSHRLLHTVKMVQNGI----RPEGIE 205 Query: 407 DIFLSGNKL-VTLPKINLTAN-LIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCS 464 + L G L ++L N HL + L + LR L +L+ ++ Sbjct: 206 HLLLEGLAYCQELKVLDLQDNTFTHLGSSALAIALKSWPNLRELGLNDCLLSARGAAAVV 265 Query: 465 GDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHN 512 + EN L+ L L N ++L L + E + L L LN N Sbjct: 266 DAFSKLENIGLQTLRLQYNEIELDAVRTLKTVIDEKMPDLLFLELNGN 313 Score = 31.7 bits (70), Expect = 1.3, Method: Composition-based stats. Identities = 32/203 (15%), Positives = 65/203 (32%), Gaps = 16/203 (7%) Query: 139 GYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQ--IFLVC--EHELEPLQ 194 + L L L N + L L + N + + + LE Sbjct: 116 DFLSKHTPLEHLYLHNNGLGPQAGAKIARALQELAVNKKAKNAPPLRSIICGRNRLENGS 175 Query: 195 GKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQ 254 K + + L++ V G +++LE L +D+ N + S Sbjct: 176 MKEWAKTFQSHRLLHTVKMVQNGIRPEGIEHLLLEGLAYCQELKVLDLQDNTFTHLGSSA 235 Query: 255 AFSLILAHHIMGAGFGFHNIKDPDQNT------FAGLARSSVRHLDLSHGFVF-----SL 303 ++ L G ++ + F+ L ++ L L + + +L Sbjct: 236 -LAIALKSWPNLRELGLNDCLLSARGAAAVVDAFSKLENIGLQTLRLQYNEIELDAVRTL 294 Query: 304 NSRVFETLKDLKVLNLAYNKINK 326 + + E + DL L L N+ ++ Sbjct: 295 KTVIDEKMPDLLFLELNGNRFSE 317 Score = 30.9 bits (68), Expect = 2.8, Method: Composition-based stats. Identities = 29/159 (18%), Positives = 46/159 (28%), Gaps = 28/159 (17%) Query: 473 PSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYL-------------NSLPP 519 P L + L +N E D + L+ LYL++N L Sbjct: 94 PKLHTVRLSDNAF-GPTAQEPLIDFLSKHTPLEHLYLHNNGLGPQAGAKIARALQELAVN 152 Query: 520 GVFSHLTALRGLSLNSNRLTVLS------HNDLPANLEILDISRNQLLAPNPDVF----- 568 + LR + NRL S L + + +N + + Sbjct: 153 KKAKNAPPLRSIICGRNRLENGSMKEWAKTFQSHRLLHTVKMVQNGIRPEGIEHLLLEGL 212 Query: 569 ---VSLSVLDITHNKFICECELSTFINWLNHTNVTIAGP 604 L VLD+ N F + I + N+ G Sbjct: 213 AYCQELKVLDLQDNTFTHLGSSALAIALKSWPNLRELGL 251 >3JRN-A nrPDB Length = 176 Score = 40.5 bits (93), Expect = 0.003, Method: Composition-based stats. Identities = 17/81 (20%), Positives = 34/81 (41%), Gaps = 4/81 (4%) Query: 692 KYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNS 751 KYD +L F D ++ + L + + ++++ G+ ++ I S Sbjct: 8 KYDVFLSFRGHDT---RHNFISFLYKEL-VRRSIRTFKDDKELENGQRFSPELKSPIEVS 63 Query: 752 RKIVCLVSRHFLRDGWCLEAF 772 R V +VS ++ WCL+ Sbjct: 64 RFAVVVVSENYAASSWCLDEL 84 >6MDV-A nrPDB Length = 802 Score = 37.8 bits (86), Expect = 0.019, Method: Composition-based stats. Identities = 19/101 (18%), Positives = 36/101 (35%), Gaps = 15/101 (14%) Query: 291 RHLDLSHGFVFSLNSRVFETLKDLKVLNLAY-NKINKIADE------------AFYGLDN 337 + L L+ + +L E L L+ L L + + +I E G+ Sbjct: 381 KTLVLTGDKIQNLKG--LEKLSKLQKLELRQLSNVKEITPELLPESMKKDAELVMVGMTG 438 Query: 338 LQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQ 378 L+ LNLS L + + + D+ N + + + Sbjct: 439 LEKLNLSGLNRQTLDGIDVNSITHLTSFDISHNSLDLSEKS 479 Score = 35.5 bits (80), Expect = 0.11, Method: Composition-based stats. Identities = 17/95 (17%), Positives = 33/95 (34%), Gaps = 15/95 (15%) Query: 315 KVLNLAYNKINKIADEAFYGLDNLQVLNLSY-NLLGEL------------YSSNFYGLPK 361 K L L +KI + + L LQ L L + + E+ G+ Sbjct: 381 KTLVLTGDKIQNL--KGLEKLSKLQKLELRQLSNVKEITPELLPESMKKDAELVMVGMTG 438 Query: 362 VAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNAL 396 + ++L + + + L + D+ N+L Sbjct: 439 LEKLNLSGLNRQTLDGIDVNSITHLTSFDISHNSL 473 Score = 32.5 bits (72), Expect = 0.79, Method: Composition-based stats. Identities = 18/97 (18%), Positives = 29/97 (29%), Gaps = 14/97 (14%) Query: 48 TERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRN------------LP 95 + L+L+ + I+ + L +LQ LEL I E + Sbjct: 380 NKTLVLTGDKIQNLKG--LEKLSKLQKLELRQLSNVKEITPELLPESMKKDAELVMVGMT 437 Query: 96 NLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLS 132 L L+L L + HL + L Sbjct: 438 GLEKLNLSGLNRQTLDGIDVNSITHLTSFDISHNSLD 474 Score = 29.8 bits (65), Expect = 4.9, Method: Composition-based stats. Identities = 10/50 (20%), Positives = 19/50 (38%) Query: 310 TLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGL 359 + L+ LNL+ + + +L ++S+N L S L Sbjct: 435 GMTGLEKLNLSGLNRQTLDGIDVNSITHLTSFDISHNSLDLSEKSEDRKL 484 Score = 29.8 bits (65), Expect = 5.9, Method: Composition-based stats. Identities = 22/132 (16%), Positives = 46/132 (34%), Gaps = 7/132 (5%) Query: 448 PHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWD-----VFEGLS 502 + + L+L ++ + G + S+ LE L V G++ Sbjct: 378 RYNKTLVLTGDKIQNLKGLEKLSKLQKLELRQLSNVKEITPELLPESMKKDAELVMVGMT 437 Query: 503 HLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEIL--DISRNQL 560 L+ L L+ +L + +T L ++ N L + ++ L L +S +Q Sbjct: 438 GLEKLNLSGLNRQTLDGIDVNSITHLTSFDISHNSLDLSEKSEDRKLLMTLMEQVSNHQK 497 Query: 561 LAPNPDVFVSLS 572 + F + Sbjct: 498 ITVKNTAFENQK 509 >4NUY-A nrPDB Length = 899 Score = 37.5 bits (85), Expect = 0.026, Method: Composition-based stats. Identities = 26/177 (14%), Positives = 53/177 (29%), Gaps = 3/177 (1%) Query: 153 SKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRV 212 + S L K S ID + E + + + Sbjct: 334 HSDYSVSKALKTVMLKDKSYDLIDEKDFPDKALREAVMAQVGTRKGDLERFNGTLRLDNP 393 Query: 213 SVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFH 272 ++ + +N F+ + L +D + +N +L + Sbjct: 394 AIQSLEGLNKFKKLAQLDLIGLSRITKLDRSVLPANMKPGKDTLETVLETYKKDNKEEPA 453 Query: 273 NIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIAD 329 I +GL ++ LDLS +L TL L+ ++++ NK++ Sbjct: 454 TIPPVSLKV-SGLT--GLKELDLSGFDRETLAGLDAATLTSLEKVDISGNKLDLAPG 507 Score = 36.3 bits (82), Expect = 0.051, Method: Composition-based stats. Identities = 37/218 (16%), Positives = 69/218 (31%), Gaps = 24/218 (11%) Query: 244 GNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTF--AGLARSSVRHLDLSHGFVF 301 F +A ++ + + D+ F L + + + G + Sbjct: 323 KEFKDATDNIFHSDYSVSKALKTVMLKDKSYDLIDEKDFPDKALREAVMAQVGTRKGDLE 382 Query: 302 SLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPK 361 N + ++ L NK K+A GL + L+ S L ++ G Sbjct: 383 RFNGTLRLDNPAIQSLE-GLNKFKKLAQLDLIGLSRITKLDRS-----VLPANMKPGKDT 436 Query: 362 VAYIDLQK---NH--IAIIQDQTF--KFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNK 414 + + N A I + L L+ LDL T+ L Sbjct: 437 LETVLETYKKDNKEEPATIPPVSLKVSGLTGLKELDLSGFDRETLAG--------LDAAT 488 Query: 415 LVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQI 452 L +L K++++ N + L+ EN I +L + Sbjct: 489 LTSLEKVDISGNKLDLAPGT-ENRQIFDTMLSTISNHV 525 Score = 35.9 bits (81), Expect = 0.082, Method: Composition-based stats. Identities = 23/147 (15%), Positives = 55/147 (37%), Gaps = 9/147 (6%) Query: 428 IHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENP----SLEQLFLGEN 483 + L +++L+ L ++ L ++ L+ R + P+ +LE + Sbjct: 388 LRLDNPAIQSLEGLNKFKKLAQLDLIGLS--RITKLDRSVLPANMKPGKDTLETVLETYK 445 Query: 484 MLQLAWETELCWDVFE--GLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVL 541 + + GL+ L+ L L+ +L + LT+L + ++ N+L + Sbjct: 446 KDNKEEPATIPPVSLKVSGLTGLKELDLSGFDRETLAGLDAATLTSLEKVDISGNKLDLA 505 Query: 542 SHNDLPANLE-ILDISRNQLLAPNPDV 567 + + +L N + + V Sbjct: 506 PGTENRQIFDTMLSTISNHVGSNEQTV 532 >5LJ5-W nrPDB Length = 238 Score = 36.3 bits (82), Expect = 0.062, Method: Composition-based stats. Identities = 25/114 (21%), Positives = 44/114 (38%), Gaps = 11/114 (9%) Query: 485 LQLAWETELCWDVFEGLSH-LQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSH 543 LQL ++E + L+ +L L +N L +P S + L L N + + Sbjct: 34 LQLETDSESMPSSLKHLTKPTHILDLTNNDLIMIPD--LSRRDDIHTLLLGRNNIVEVDG 91 Query: 544 NDLPANLEILDISRNQLLAPNP-----DVFVSLSVLDITHNKFICECELSTFIN 592 LP N++ L +S N + +L L + N+ C L+ + Sbjct: 92 RLLPMNVQNLTLSNNSIRRFEDLQRLRRAPRTLKNLTLIGNQV---CHLANYRE 142 Score = 33.6 bits (75), Expect = 0.36, Method: Composition-based stats. Identities = 25/146 (17%), Positives = 53/146 (36%), Gaps = 22/146 (15%) Query: 216 WGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGF------ 269 + N + ++L L + + + + + + + L IM Sbjct: 19 FNGKYNVDKCVILRDLQLETD--SESMPSSLKHLTKPTHILDLTNNDLIMIPDLSRRDDI 76 Query: 270 -----GFHNIKDPDQNTFAGLARSSVRHLDLSHGFV--FSLNSRVFETLKDLKVLNLAYN 322 G +NI + D L +V++L LS+ + F R+ + LK L L N Sbjct: 77 HTLLLGRNNIVEVD----GRLLPMNVQNLTLSNNSIRRFEDLQRLRRAPRTLKNLTLIGN 132 Query: 323 KINKIAD---EAFYGLDNLQVLNLSY 345 ++ +A+ + +L+ L+ Sbjct: 133 QVCHLANYREHVLRLVPHLETLDFQN 158 Score = 32.5 bits (72), Expect = 0.81, Method: Composition-based stats. Identities = 23/102 (22%), Positives = 40/102 (39%), Gaps = 10/102 (9%) Query: 302 SLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPK 361 S+ S + K +L+L N + I D + D++ L L N + E+ Sbjct: 42 SMPSSLKHLTKPTHILDLTNNDLIMIPDLSRR--DDIHTLLLGRNNIVEVDGRLLP--MN 97 Query: 362 VAYIDLQKNHIAIIQDQTFKFLEK----LQTLDLRDNALTTI 399 V + L N I +D + L + L+ L L N + + Sbjct: 98 VQNLTLSNNSIRRFED--LQRLRRAPRTLKNLTLIGNQVCHL 137 >2M1W-A nrPDB Length = 166 Score = 34.8 bits (78), Expect = 0.18, Method: Composition-based stats. Identities = 14/59 (23%), Positives = 28/59 (47%) Query: 737 GENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSL 795 G + N+ DA+ S + L++ +FLRD WC F + ++ + ++ + L Sbjct: 49 GRQHLQNLDDAVNGSAWTILLLTENFLRDTWCNFQFYTSLMNSVNRQHKYNSVIPMRPL 107 >2P1O-B nrPDB Length = 594 Score = 32.8 bits (73), Expect = 0.59, Method: Composition-based stats. Identities = 34/251 (13%), Positives = 73/251 (29%), Gaps = 37/251 (14%) Query: 238 WTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGL----------AR 287 W ++ +++ ++ + F N K ++ G Sbjct: 96 WIEAMSSSYTWLEEIRLKRMVVTDDCLELIAKSFKNFKVLVLSSCEGFSTDGLAAIAATC 155 Query: 288 SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNL 347 +++ LDL V ++ D ++ N ++ +F L+ L Sbjct: 156 RNLKELDLRESDVDDVSGHWLSHFPDTYTSLVSLNISCLASEVSFSA---LERLVTRCPN 212 Query: 348 LGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPD 407 L L + L K+A + + +L+ L + S Sbjct: 213 LKSLKLNRAVPLEKLATL--------------LQRAPQLEELGTGGYTAEVRPDVYSGLS 258 Query: 408 IFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQ 467 + LSG K ++ + L + + L L L+ S + Sbjct: 259 VALSGCK-----ELRCLSGFWDAVPAYLPAVYSV-----CSRLTTLNLSYATVQSYDLVK 308 Query: 468 TPSENPSLEQL 478 + P L++L Sbjct: 309 LLCQCPKLQRL 319 >4ZL4-A nrPDB Length = 444 Score = 32.8 bits (73), Expect = 0.72, Method: Composition-based stats. Identities = 36/185 (19%), Positives = 69/185 (37%), Gaps = 12/185 (6%) Query: 385 KLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFL 444 K++ LD+ + + + + SG+ +P+ +L N ++ + L D+ Sbjct: 258 KVRGLDMFGTNM--MSSSKGLEMLVDSGSTFTHIPE-DLY-NKLNYFFDILCIQDMNNAY 313 Query: 445 LRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHL 504 L++ + N Q SL+ + ENM + CW EGL L Sbjct: 314 DVNKRLKMTNESFNN----PLVQFDDFRKSLKSIIAKENMCVKIVDGVQCWKYLEGLPDL 369 Query: 505 QVLYLNHNYLNSLPPGVFSHLTA---LRGLSLNSNRLTVLSHNDLPANLEILDISRNQLL 561 V L++NY P + + +G+ N +L I DI +N++ Sbjct: 370 FV-TLSNNYKMKWQPHSYLYKKESFWCKGIEKQVNNKPILGLTFFKNRQVIFDIQKNRIG 428 Query: 562 APNPD 566 + + Sbjct: 429 FVDAN 433 >4UF0-B nrPDB Length = 478 Score = 32.5 bits (72), Expect = 0.88, Method: Composition-based stats. Identities = 24/147 (16%), Positives = 39/147 (26%), Gaps = 5/147 (3%) Query: 446 RVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENM-LQLAWETELCWDVFEGLSHL 504 H I Q + SS + +N F+ + Sbjct: 97 NRSHTTIAKYAQYQASSFQESLREENEKRTQHKDHSDNESTSSENSGRRRKGPFKTIKFG 156 Query: 505 QVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPN 564 + L+ N L + L A + N LT + H L N L + P Sbjct: 157 TNIDLSDNKKWKLQLHELTKLPAFARVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPG 216 Query: 565 PDVFVSLSVLDITHNKFICECELSTFI 591 + ++I CE F+ Sbjct: 217 HQENNNFCSVNINIGPGDCE----WFV 239 >6FE8-D nrPDB Length = 519 Score = 32.1 bits (71), Expect = 1.1, Method: Composition-based stats. Identities = 44/287 (15%), Positives = 93/287 (32%), Gaps = 32/287 (11%) Query: 326 KIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEK 385 I AF LD L V N+ +N+ L + DL I +Q + + + Sbjct: 152 VIDSVAFDELDLLNVSNIQFNIDNLTPQLVDKCLSILEQKDLFAT-IGEVQFGQDEEVGE 210 Query: 386 LQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANL----IHLSENRLENLDIL 441 + +D+ S P + NK + K + + N H + + + Sbjct: 211 EKDVDVSGAN----SDENSSPSSTIK-NKKRSASKRSHSDNGNVGATHNQLTSISVIRTI 265 Query: 442 YFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGL 501 + + L+ + + + L +L + + + + + V Sbjct: 266 RSMESMKSLRKITVRGEK---------------LYELLINFHGFRDNPGKTISYIVKR-- 308 Query: 502 SHLQVLYLNH-NYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDI---SR 557 + + L+ N ++ F+ L+ L L+ L+ P N + L + S+ Sbjct: 309 -RINEIRLSRMNQISRTGLADFTRWDNLQKLVLSRVAYIDLNSIVFPKNFKSLTMKRVSK 367 Query: 558 NQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGP 604 + ++ L V T + + S F + N + I Sbjct: 368 IKWWNIEENILKELKVDKRTFKSLYIKEDDSKFTKFFNLRHTRIKEL 414 >5N23-A nrPDB Length = 352 Score = 32.1 bits (71), Expect = 1.2, Method: Composition-based stats. Identities = 29/163 (17%), Positives = 48/163 (29%), Gaps = 4/163 (2%) Query: 15 AGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQL 74 A G S +A + L + T L F IRT+ SF + ++ Sbjct: 5 AAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLD-QFERIRTLGTGSFGRVMLVKH 63 Query: 75 LELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDA 134 E G+ Y +DK + + L+ ++ ++ F L L L Sbjct: 64 KETGNHYAMKILDK---QKVVKLKQIEHTLNEKRIQQAVNFPFLVKLEFSFKDNSNLYMV 120 Query: 135 VLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDF 177 + L R+ Y L S+D Sbjct: 121 LEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 163 >4LZP-B nrPDB Length = 176 Score = 31.7 bits (70), Expect = 1.3, Method: Composition-based stats. Identities = 16/89 (17%), Positives = 34/89 (38%), Gaps = 5/89 (5%) Query: 685 GTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANI 744 T +YD ++ +S+D + A ++ L D + ++ G++ I Sbjct: 37 ATMEAEEEYDFFISHASED----KEAFVQDLVAALRDLGA-KIFYDAYTLKVGDSLRRKI 91 Query: 745 QDAIWNSRKIVCLVSRHFLRDGWCLEAFS 773 + NS+ + ++S HF W Sbjct: 92 DQGLANSKFGIVVLSEHFFSKQWPARELD 120 >5YTI-A nrPDB Length = 411 Score = 30.9 bits (68), Expect = 2.3, Method: Composition-based stats. Identities = 46/336 (13%), Positives = 108/336 (32%), Gaps = 36/336 (10%) Query: 85 TIDKEAFRNLPNLRILDL--GSSKIYFLHPDAF----QGLFHLFELRLYFCGLSDAVLKD 138 I A +L LR + + G+ + Q L + L S+ Sbjct: 78 GILSNAVNSLHRLREIQIQAGNPSLSEEDRKTLAVEAQALLN-QLLDYANTKDSNGSYMF 136 Query: 139 GYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNS---LKSIDFSSNQIFLV----CEHELE 191 ++L L+LS + + F + + + D N + + Sbjct: 137 SGSKSLTQPVSLNLSGQYVYNGDSTQRFQAVTTSLLVAVNDTGDNVFMRIPSGNGRFAIR 196 Query: 192 PLQGKTLSFFSLAANSLYSRVSVDWGK-----CMNPFRNMVLEILD-VSGNGWTVDITGN 245 S+++ S+ + + +N N+V+ + +SGN + Sbjct: 197 ETLTPNTGTASVSSGSVTNEAAFVPDNYTMTFALNSQGNLVVMVSGTLSGNVIPPSGLPD 256 Query: 246 FSNAISKSQAFSL----ILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVF 301 + + A ++ + AG F +++ F+ + R + +L+ + Sbjct: 257 DAPLYQEGSAIGFNGMEMVVSGLPKAGDSFSISPAKNESIFSTVQRM-INNLNKPYTSSV 315 Query: 302 SLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQ--------VLNLSYNLLGELYS 353 + E + L ++ A I + + L+ L+ L++S L +L Sbjct: 316 EKAATQTENNQLLAQIDSALGHILSVQSDLGARLNQLETAEKANNDYLDISAATLKKLRE 375 Query: 354 SNFYGLP---KVAYIDLQKNHIAIIQDQTFKFLEKL 386 + + + ++LQ ++ + Q L Sbjct: 376 IDPVAVATELNLQLVNLQAAQLSFTRIQGLSLFNFL 411 >3H16-A nrPDB Length = 154 Score = 30.1 bits (66), Expect = 4.2, Method: Composition-based stats. Identities = 9/38 (23%), Positives = 19/38 (50%) Query: 736 PGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFS 773 PG++ +I + +SR + ++S HF + W + Sbjct: 59 PGDSLRRSIDKGLGSSRFGIVVLSTHFFKKEWPQKELD 96 >1P9B-A nrPDB Length = 442 Score = 30.1 bits (66), Expect = 4.5, Method: Composition-based stats. Identities = 24/154 (15%), Positives = 56/154 (36%), Gaps = 8/154 (5%) Query: 387 QTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLR 446 + + N + IH + +I G KL L ++ L+ N H+ + + +D + + Sbjct: 76 NNISVLGNGMV-IHVKSLMEEIESVGGKL--LDRLYLS-NKAHILFDIHQIIDSIQETKK 131 Query: 447 VPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLS---H 503 + + + + C + L L EN + + ++ Sbjct: 132 LKEGKQIGTTKRGIGPCYSTKASRIGIRLGTLKNFENFKNMYSKLIDHLMDLYNITEYDK 191 Query: 504 LQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNR 537 + L L +NY L + ++ + +L +N+ Sbjct: 192 EKELNLFYNYHIKLRDRIVDVISFMNT-NLENNK 224 >6MZB-A nrPDB Length = 859 Score = 29.8 bits (65), Expect = 5.5, Method: Composition-based stats. Identities = 44/278 (15%), Positives = 83/278 (29%), Gaps = 25/278 (8%) Query: 108 YFLHPDAFQGLFHLFELRLYFCGL---SDAVLKDGYFRNLKALT----RLDLSKNQIRSL 160 Y ++ F L L EL L CG+ + + D + +AL L +I Sbjct: 501 YEINKFHFSDLP-LTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRRITYH 559 Query: 161 YLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFS----LAANSLYSRVSVDW 216 F ++ S+ + +LE L T +F N+LY S + Sbjct: 560 NWRHGFNVGQTMFSLLVTGKLKRYFT--DLEALAMVTAAFCHDIDHRGTNNLYQMKSQNP 617 Query: 217 GKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKS----------QAFSLILAHHIMG 266 ++ + L+ + F N + + LA + Sbjct: 618 LAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKK 677 Query: 267 AGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINK 326 F I D + + LD + + L + +K+ Sbjct: 678 RTM-FQKIVDQSKTYETQQEWTQYMMLDQTRKEIVMAMMMTACDLSAITKPWEVQSKVAL 736 Query: 327 IADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAY 364 + F+ +L+ L N + + + LPK+ Sbjct: 737 LVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQV 774 >3OL6-A nrPDB Length = 471 Score = 29.4 bits (64), Expect = 6.4, Method: Composition-based stats. Identities = 13/67 (19%), Positives = 27/67 (40%), Gaps = 4/67 (5%) Query: 561 LAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVS 620 + +P F +L ++ I + +I++LNH++ + P SG S Sbjct: 239 ASLSPAWFEALKMVLEK----IGFGDRVDYIDYLNHSHHLYKNKTYCVKGGMPSGCSGTS 294 Query: 621 LFSLSTE 627 +F+ Sbjct: 295 IFNSMIN 301 >2IJD-1 nrPDB Length = 644 Score = 29.4 bits (64), Expect = 6.4, Method: Composition-based stats. Identities = 13/67 (19%), Positives = 27/67 (40%), Gaps = 4/67 (5%) Query: 561 LAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVS 620 + +P F +L ++ I + +I++LNH++ + P SG S Sbjct: 422 ASLSPAWFEALKMVLEK----IGFGDRVDYIDYLNHSHHLYKNKTYCVKGGMPSGCSGTS 477 Query: 621 LFSLSTE 627 +F+ Sbjct: 478 IFNSMIN 484 >1RAJ-A nrPDB Length = 393 Score = 29.4 bits (64), Expect = 7.0, Method: Composition-based stats. Identities = 13/67 (19%), Positives = 27/67 (40%), Gaps = 4/67 (5%) Query: 561 LAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVS 620 + +P F +L ++ I + +I++LNH++ + P SG S Sbjct: 171 ASLSPAWFEALKMVLEK----IGFGDRVDYIDYLNHSHHLYKNKTYCVKGGMPSGCSGTS 226 Query: 621 LFSLSTE 627 +F+ Sbjct: 227 IFNSMIN 233 >5WLC-LS nrPDB Length = 594 Score = 29.4 bits (64), Expect = 7.7, Method: Composition-based stats. Identities = 45/299 (15%), Positives = 88/299 (29%), Gaps = 29/299 (9%) Query: 339 QVLNLSYNLLGELYSSNFYGLPKVAYIDL-----QKNHIAIIQDQTFKFLEKL------- 386 ++L+ +YN L +S K+ + L + IQ +F + L Sbjct: 210 KILSTTYNYKDTLSNSKLLPPKKLDIVRLKDANASHPSHSAIQSLSFHPSKPLLLTGGYD 269 Query: 387 QTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKI-NLTANLIHLSENRLENLDILYFLL 445 +TL + T H + S+ + + N I + R L Sbjct: 270 KTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQNIFTAGRRRYMHSWDLSLE 329 Query: 446 RVPHLQILILNQ-NRFSSCSGDQTPSENPSLEQL-FLGENMLQLAWETELCWDVFEGLSH 503 + H Q + + +R Q EN + L N + + L Sbjct: 330 NLTHSQTAKIEKFSRLYGHESTQRSFENFKVAHLQNSQTNSVHGIVLLQGNNGWINILHS 389 Query: 504 LQVLYLNHNYLNSLPPGVFSHLTAL-----RGLSLNSNRLTVLSHNDLPANLEIL----D 554 L+L + + + R + + N + DL N ++ D Sbjct: 390 TSGLWLMGCKIEGVITDFCIDYQPISRGKFRTILIAVNAYGEVWEFDLNKNGHVIRRWKD 449 Query: 555 ISRNQLLAPNPD-----VFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADI 608 + +L + I N+++ S F+N + N + P + Sbjct: 450 QGGVGITKIQVGGGTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPV 508 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.313 0.124 0.308 Lambda K H 0.267 0.0382 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 27,552,512 Number of Sequences: 36641 Number of extensions: 1044030 Number of successful extensions: 7580 Number of sequences better than 10.0: 99 Number of HSP's better than 10.0 without gapping: 120 Number of HSP's successfully gapped in prelim test: 48 Number of HSP's that attempted gapping in prelim test: 3293 Number of HSP's gapped (non-prelim): 703 length of query: 858 length of database: 10,336,785 effective HSP length: 105 effective length of query: 753 effective length of database: 6,489,480 effective search space: 4886578440 effective search space used: 4886578440 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.1 bits) S2: 63 (29.0 bits)