BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= O49482 (357 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2CF5-A nrPDB 733 0.0 1YQX-A nrPDB 378 e-105 5Z0C-A nrPDB 355 2e-98 5VKT-A nrPDB 338 2e-93 5FI5-A nrPDB 317 7e-87 5H83-A nrPDB 300 5e-82 5H82-A nrPDB 292 1e-79 1UUF-A nrPDB 269 1e-72 3TWO-A nrPDB 246 1e-65 4OAQ-A nrPDB 202 2e-52 1Q1N-A nrPDB 182 2e-46 3PII-A nrPDB 169 1e-42 6C49-A nrPDB 159 1e-39 6N7L-A nrPDB 155 2e-38 3S2F-A nrPDB 149 2e-36 3MEQ-A nrPDB 145 4e-35 1LLU-A nrPDB 142 3e-34 4EEZ-A nrPDB 137 5e-33 4Z6K-A nrPDB 132 3e-31 5ENV-A nrPDB 125 2e-29 2EER-A nrPDB 111 5e-25 5YAT-A nrPDB 108 3e-24 4GKV-A nrPDB 107 5e-24 1H2B-A nrPDB 107 1e-23 1R37-A nrPDB 105 2e-23 6FG0-A nrPDB 103 8e-23 5K1S-A nrPDB 98 4e-21 2H6E-A nrPDB 91 6e-19 2DFV-A nrPDB 89 3e-18 3GFB-A nrPDB 85 5e-17 5KIA-A nrPDB 81 7e-16 3WLE-A nrPDB 80 1e-15 1U3W-A nrPDB 79 4e-15 3UOG-A nrPDB 79 4e-15 1HSZ-A nrPDB 77 1e-14 1HSO-A nrPDB 76 2e-14 3IP1-A nrPDB 76 2e-14 1CDO-A nrPDB 75 4e-14 5YLN-A nrPDB 73 2e-13 4EJ6-A nrPDB 73 2e-13 1D1T-A nrPDB 70 2e-12 4RQU-A nrPDB 69 3e-12 4ILK-A nrPDB 69 4e-12 4CPD-A nrPDB 69 4e-12 1EE2-A nrPDB 68 5e-12 4JJI-A nrPDB 67 8e-12 4UEJ-A nrPDB 65 3e-11 4OH1-A nrPDB 65 3e-11 5VM2-A nrPDB 65 4e-11 1F8F-A nrPDB 65 4e-11 3QE3-A nrPDB 64 1e-10 4DLA-A nrPDB 62 3e-10 2DQ4-A nrPDB 62 3e-10 1E3J-A nrPDB 62 3e-10 1P0F-A nrPDB 62 3e-10 3FBG-A nrPDB 62 5e-10 1PL8-A nrPDB 62 5e-10 3TQH-A nrPDB 60 1e-09 3COS-A nrPDB 60 1e-09 1MC5-A nrPDB 59 3e-09 5A3V-A nrPDB 58 5e-09 5TNX-A nrPDB 57 1e-08 1E3E-A nrPDB 57 1e-08 2VN8-A nrPDB 56 2e-08 3FSR-A nrPDB 50 1e-06 1YKF-A nrPDB 50 1e-06 4JLW-A nrPDB 49 3e-06 3FPL-A nrPDB 47 9e-06 1KEV-A nrPDB 47 9e-06 4IDE-A nrPDB 47 1e-05 1KOL-A nrPDB 47 1e-05 3FPC-A nrPDB 47 1e-05 6DKH-A nrPDB 47 2e-05 3M6I-A nrPDB 47 2e-05 2VCY-A nrPDB 46 2e-05 3JYN-A nrPDB 45 3e-05 2DPH-A nrPDB 45 5e-05 4A27-A nrPDB 45 7e-05 2OUI-A nrPDB 44 2e-04 3B70-A nrPDB 42 4e-04 2OBY-A nrPDB 42 5e-04 4Y1B-A nrPDB 40 0.001 1YB5-A nrPDB 38 0.008 1O89-A nrPDB 36 0.026 5GXF-A nrPDB 36 0.030 4DVJ-A nrPDB 35 0.069 1WLY-A nrPDB 35 0.074 4RVS-A nrPDB 34 0.096 6BII-A nrPDB 33 0.17 3SLK-A nrPDB 33 0.20 5LB9-A nrPDB 33 0.20 5NGJ-A nrPDB 32 0.33 2CDC-A nrPDB 32 0.40 2EEZ-A nrPDB 32 0.40 4A10-A nrPDB 32 0.49 5AOV-A nrPDB 32 0.52 2WEK-A nrPDB 31 0.73 1QOR-A nrPDB 30 1.2 2QYS-A nrPDB 30 1.2 4EYE-A nrPDB 30 1.3 5N2I-A nrPDB 30 1.8 4IZO-A nrPDB 30 2.0 4JRO-A nrPDB 30 2.2 6BMA-A nrPDB 29 2.7 4WGX-A nrPDB 29 3.2 5J3E-A nrPDB 28 6.1 4NBV-A nrPDB 28 6.4 5OL2-B nrPDB 28 6.7 5JJC-A nrPDB 28 6.8 1NVT-A nrPDB 28 8.7 2NRJ-A nrPDB 27 9.1 >2CF5-A nrPDB Length = 357 Score = 733 bits (1893), Expect = 0.0, Method: Compositional matrix adjust. Identities = 357/357 (100%), Positives = 357/357 (100%) Query: 1 MGIMEAERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGM 60 MGIMEAERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGM Sbjct: 1 MGIMEAERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGM 60 Query: 61 SNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWS 120 SNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWS Sbjct: 61 SNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWS 120 Query: 121 YNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQP 180 YNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQP Sbjct: 121 YNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQP 180 Query: 181 GLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSE 240 GLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSE Sbjct: 181 GLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSE 240 Query: 241 LADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFI 300 LADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFI Sbjct: 241 LADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFI 300 Query: 301 GSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGSNLDA 357 GSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGSNLDA Sbjct: 301 GSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGSNLDA 357 >1YQX-A nrPDB Length = 366 Score = 378 bits (970), Expect = e-105, Method: Compositional matrix adjust. Identities = 188/349 (53%), Positives = 245/349 (70%), Gaps = 1/349 (0%) Query: 9 KTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPG 68 K GWAARD SG LSP+ ++ R TG EDV +++ CG+CH+DLH KND G S YP+VPG Sbjct: 16 KAFGWAARDQSGHLSPFNFSRRATGEEDVRFKVLYCGVCHSDLHSIKNDWGFSMYPLVPG 75 Query: 69 HEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYING 128 HE+VGEV EVGS V K VGD VGVGCLVG C C C DLE YCPK I +Y +Y +G Sbjct: 76 HEIVGEVTEVGSKVKKVNVGDKVGVGCLVGACHSCESCANDLENYCPKMILTYASIYHDG 135 Query: 129 QPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILG 188 T GG++ V +++++++ P+ M ++ APLLCAG+TVYSPL +FGL +PG GI+G Sbjct: 136 TITYGGYSNHMVANERYIIRFPDNMPLDGGAPLLCAGITVYSPLKYFGLDEPGKHIGIVG 195 Query: 189 LGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDYV 248 LGG+GH+ VK AKA G VTVIS+S K+EEAL++ GAD +++ DQ +M A +LD + Sbjct: 196 LGGLGHVAVKFAKAFGSKVTVISTSPSKKEEALKNFGADSFLVSRDQEQMQAAAGTLDGI 255 Query: 249 IDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEE 308 IDTV H L P LLK GKLIL+G PL+ L+ GRK++ GS IG MKET+E Sbjct: 256 IDTVSAVHPLLPLFGLLKSHGKLILVGAPEKPLELPAFSLIAGRKIVAGSGIGGMKETQE 315 Query: 309 MLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGSNLDA 357 M++F + +++ IEV+ DY+NTA ERL KNDVRYRFV+DV G+ L A Sbjct: 316 MIDFAAKHNITADIEVISTDYLNTAMERLAKNDVRYRFVIDV-GNTLAA 363 >5Z0C-A nrPDB Length = 374 Score = 355 bits (911), Expect = 2e-98, Method: Compositional matrix adjust. Identities = 177/356 (49%), Positives = 247/356 (69%) Query: 2 GIMEAERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMS 61 G E K GWAARDPSG LSP+T++ R TG DV +++ CGICH+DLH KN+ + Sbjct: 6 GTEEHTVKAVGWAARDPSGHLSPFTFSRRATGELDVTFKVLYCGICHSDLHYIKNEWSNT 65 Query: 62 NYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSY 121 YP +PGHE+VGEV EVGS V+KF VGD VGVGC+VG C C C LE YCP +I ++ Sbjct: 66 IYPALPGHEIVGEVTEVGSKVNKFKVGDKVGVGCIVGSCHSCPNCNNHLENYCPNRILTF 125 Query: 122 NDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPG 181 Y +G GG++ VV + F V+IP+ + ++ AAPLLCAG+TVYSPL ++GL +PG Sbjct: 126 GSRYYDGTLNHGGYSDLMVVQEHFAVRIPDALPLDSAAPLLCAGITVYSPLRYYGLDKPG 185 Query: 182 LRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL 241 L G++GLGG+GHM VK AKA G VTV+S+S K+E+A+ LGA +++ +D +M Sbjct: 186 LHVGVVGLGGLGHMAVKFAKAFGVKVTVVSTSPAKKEDAISGLGAHSFILSTDAEQMQAA 245 Query: 242 ADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIG 301 ++D +IDTV H L P +SLLK GKL+++G PL+ L+LGRK++ GS IG Sbjct: 246 VGTMDGIIDTVSASHPLPPLISLLKSHGKLVMVGDPPKPLELPVFPLLLGRKMVAGSAIG 305 Query: 302 SMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGSNLDA 357 MKET+EM++F ++G+ + +EV+ MDYVNTA +R+ K+DV+YRFV+D+ + D+ Sbjct: 306 GMKETQEMIDFAAKEGVRADVEVIPMDYVNTAMQRVSKSDVKYRFVIDIGNTFNDS 361 >5VKT-A nrPDB Length = 362 Score = 338 bits (868), Expect = 2e-93, Method: Compositional matrix adjust. Identities = 183/356 (51%), Positives = 244/356 (68%), Gaps = 3/356 (0%) Query: 4 MEAERKTT-GWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSN 62 ME KT GWAARD SG LSPY+++ R G DV I+++ CGICHTDLH KN+ G + Sbjct: 3 MEQGCKTAHGWAARDASGHLSPYSFSARIQGDADVTIKVLFCGICHTDLHVIKNEWGNAM 62 Query: 63 YPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYN 122 YP+VPGHEVVG V +VG V+KF GD VGVG V C C C E YCP + + N Sbjct: 63 YPVVPGHEVVGVVTDVGHGVTKFKAGDTVGVGYFVDSCRTCESCSTGHENYCPDLVLTSN 122 Query: 123 --DVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQP 180 D + +G T+GGF+ VV Q FVV++PE + ++ AAPLLCAGVTVYSP++ + L +P Sbjct: 123 GVDHHHHGATTKGGFSDVLVVSQDFVVRVPESLPLDGAAPLLCAGVTVYSPMAQYALNEP 182 Query: 181 GLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSE 240 G G++GLGG+GHM VK AKA G VTVISSS KR+EAL LGAD +++ D A+M Sbjct: 183 GKHLGVVGLGGLGHMAVKFAKAFGMTVTVISSSPGKRDEALGRLGADAFLVSHDAAQMKA 242 Query: 241 LADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFI 300 A +LD +IDTV H + P L+LLK G+++++G + PL+ ++ G K + G+ + Sbjct: 243 AAATLDGIIDTVSAGHQIVPLLALLKPMGQMVVVGAPSTPLELPAYAIITGGKRVAGNGV 302 Query: 301 GSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGSNLD 356 GS+ + + ML+F E G+++ IEVV+MDYVNTA ERLEKNDVRYRFV+DV GS ++ Sbjct: 303 GSVADCQAMLDFAGEHGVTADIEVVQMDYVNTAIERLEKNDVRYRFVIDVAGSKME 358 >5FI5-A nrPDB Length = 357 Score = 317 bits (811), Expect = 7e-87, Method: Compositional matrix adjust. Identities = 159/342 (46%), Positives = 225/342 (65%), Gaps = 8/342 (2%) Query: 9 KTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPG 68 K G AA+D SG+ SP+ ++ R TG DV ++++ CG C D +KN G ++YP V G Sbjct: 17 KAFGLAAKDSSGLFSPFNFSRRATGEHDVQLKVLYCGTCQYDREMSKNKFGFTSYPYVLG 76 Query: 69 HEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYING 128 HE+VGEV EVGS V KF VGD VGV ++ CG C C ++E YCP+ S + Y Sbjct: 77 HEIVGEVTEVGSKVQKFKVGDKVGVASIIETCGKCEMCTNEVENYCPEA-GSIDSNY--- 132 Query: 129 QPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILG 188 G + V+++ FV++ PE + ++ PLLCAG+T YSP+ +GL +PG R GI G Sbjct: 133 ----GACSNIAVINENFVIRWPENLPLDSGVPLLCAGITAYSPMKRYGLDKPGKRIGIAG 188 Query: 189 LGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDYV 248 LGG+GH+ ++ AKA G VTVISSS KK+ EA + GAD +++ S+ +M A +LD + Sbjct: 189 LGGLGHVALRFAKAFGAKVTVISSSLKKKREAFEKFGADSFLVSSNPEEMQGAAGTLDGI 248 Query: 249 IDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEE 308 IDT+P +H+LEP L+LLK GKLI++G P + P L++G KV+ S GSMKE +E Sbjct: 249 IDTIPGNHSLEPLLALLKPLGKLIILGAPEMPFEVPAPSLLMGGKVMAASTAGSMKEIQE 308 Query: 309 MLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDV 350 M+EF E + + +EV+ +DYVNTA ERL+ +DVRYRFV+D+ Sbjct: 309 MIEFAAEHNIVADVEVISIDYVNTAMERLDNSDVRYRFVIDI 350 >5H83-A nrPDB Length = 360 Score = 300 bits (769), Expect = 5e-82, Method: Compositional matrix adjust. Identities = 159/342 (46%), Positives = 224/342 (65%), Gaps = 4/342 (1%) Query: 9 KTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPG 68 KT G+AA+D SG SP+ ++ R TG DV +++ CG C+ DL + N GM+ YP V G Sbjct: 14 KTFGFAAKDSSGFFSPFNFSRRATGENDVQFKVLYCGTCNYDLEMSTNKFGMTKYPFVIG 73 Query: 69 HEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYING 128 HE+VG V E+GS V KF VGD VGVG VG C C C +E C K+ S + + N Sbjct: 74 HEIVGVVTEIGSKVQKFKVGDKVGVGGFVGACEKCEMCVNGVENNC-SKVESTDGHFGN- 131 Query: 129 QPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILG 188 GG VV++K+ V PE + + PLLCAG+T YSPL +GL +PGL GI G Sbjct: 132 --NFGGCCNIMVVNEKYAVVWPENLPLHSGVPLLCAGITTYSPLRRYGLDKPGLNIGIAG 189 Query: 189 LGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDYV 248 LGG+GH+ ++ AKA G VT+ISSS KK+ EAL+ G D +++ S+ +M +LD + Sbjct: 190 LGGLGHLAIRFAKAFGAKVTLISSSVKKKREALEKFGVDSFLLNSNPEEMQGAYGTLDGI 249 Query: 249 IDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEE 308 IDT+PV H++ P+L+LLK GKLI++GV P + P L++G K+I GS GSMKET+E Sbjct: 250 IDTMPVAHSIVPFLALLKPLGKLIILGVPEEPFEVPAPALLMGGKLIAGSAAGSMKETQE 309 Query: 309 MLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDV 350 M++F + + + +EV+ +DY+NTA ER++ +DV+YRFV+DV Sbjct: 310 MIDFAAKHNIVADVEVIPIDYLNTAMERIKNSDVKYRFVIDV 351 >5H82-A nrPDB Length = 389 Score = 292 bits (748), Expect = 1e-79, Method: Compositional matrix adjust. Identities = 149/355 (41%), Positives = 217/355 (61%), Gaps = 13/355 (3%) Query: 12 GWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEV 71 GWAA+D SG+LSP+ + R TG DV +++ CG+C D+ TKN G + YP VPGHE+ Sbjct: 31 GWAAKDTSGLLSPFKFLRRTTGEHDVQFKVLYCGLCDWDVITTKNTYGTTKYPFVPGHEI 90 Query: 72 VGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWS----------- 120 +G V E+G+ V KF VGD VGVG +G CG C C LE YCPK I++ Sbjct: 91 MGIVTEIGNKVKKFKVGDKVGVGNFIGSCGKCERCNEGLEPYCPKVIYTDGTAFSDENNT 150 Query: 121 -YNDVYINGQPT-QGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLK 178 Y DV +G+ GG++ V ++ V + PE + + P+LC G+ YSP+ HFGL Sbjct: 151 VYGDVSGDGEDRIYGGYSNIMVANEYVVFRWPENLPLAAGVPILCGGIVPYSPMRHFGLD 210 Query: 179 QPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKM 238 +PGL G++G G +G + VK AKA G +VTVIS+S K++EA++ G D ++I + +M Sbjct: 211 KPGLSIGVVGFGRIGKLAVKFAKAFGANVTVISTSISKKQEAIEKYGVDRFLISKEPEEM 270 Query: 239 SELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGS 298 +LD + D VP H L P L+LLK +G +++GV + L++GR+ GS Sbjct: 271 KAAESTLDGIFDCVPSVHPLHPLLNLLKFEGTFVMLGVAVEAYELPVSPLLMGRRKFVGS 330 Query: 299 FIGSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGS 353 G+MKET+EML+F + + S IE++ MDYVNTA ER+ K + + FV+D+E + Sbjct: 331 ISGTMKETQEMLDFAAKHNIVSDIELIPMDYVNTALERIAKGNHKDAFVIDIENT 385 >1UUF-A nrPDB Length = 369 Score = 269 bits (688), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 148/342 (43%), Positives = 216/342 (63%), Gaps = 10/342 (2%) Query: 12 GWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEV 71 ++A+ P L P T RE GP DV I I CG+CH+DLHQ +++ + YP VPGHE+ Sbjct: 28 AYSAKQP---LEPMDITRREPGPNDVKIEIAYCGVCHSDLHQVRSEWAGTVYPCVPGHEI 84 Query: 72 VGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQP- 130 VG VV VG V K+ GD+VGVGC+V C C CE LE YC +YN + +P Sbjct: 85 VGRVVAVGDQVEKYAPGDLVGVGCIVDSCKHCEECEDGLENYCDHMTGTYNSPTPD-EPG 143 Query: 131 -TQGGFAKATVVHQKFVVKIPEGM-AVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILG 188 T GG+++ VVH+++V++I + APLLCAG+T YSPL H+ PG + G++G Sbjct: 144 HTLGGYSQQIVVHERYVLRIRHPQEQLAAVAPLLCAGITTYSPLRHWQ-AGPGKKVGVVG 202 Query: 189 LGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDYV 248 +GG+GHMG+K+A AMG HV ++S KR EA + LGAD+ V + +M+ S D++ Sbjct: 203 IGGLGHMGIKLAHAMGAHVVAFTTSEAKR-EAAKALGADEVVNSRNADEMAAHLKSFDFI 261 Query: 249 IDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPL-LMLGRKVITGSFIGSMKETE 307 ++TV H L+ + +LLK DG + L+G P + L++ R+ I GS IG + ET+ Sbjct: 262 LNTVAAPHNLDDFTTLLKRDGTMTLVGAPATPHKSPEVFNLIMKRRAIAGSMIGGIPETQ 321 Query: 308 EMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVD 349 EML+FC E G+ + IE+++ D +N A+ER+ + DV+YRFV+D Sbjct: 322 EMLDFCAEHGIVADIEMIRADQINEAYERMLRGDVKYRFVID 363 >3TWO-A nrPDB Length = 348 Score = 246 bits (627), Expect = 1e-65, Method: Compositional matrix adjust. Identities = 125/350 (35%), Positives = 202/350 (57%), Gaps = 12/350 (3%) Query: 9 KTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPG 68 ++ G+A P+ ++ GP DV I I+ GICH+D+H ++ YPM+PG Sbjct: 4 QSKGFAIFSKDEHFKPHDFSRHAVGPRDVLIDILYAGICHSDIHSAYSEWKEGIYPMIPG 63 Query: 69 HEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYN--DVYI 126 HE+ G + EVG V KF +GD+VGVGC V C C PC+ EQ+C K +++Y+ D + Sbjct: 64 HEIAGIIKEVGKGVKKFKIGDVVGVGCFVNSCKACKPCKEHQEQFCTKVVFTYDCLDSFH 123 Query: 127 NGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGI 186 + +P GG++ VV + +V+ + + +E+ APLLCAG+T YSPL F G + G+ Sbjct: 124 DNEPHMGGYSNNIVVDENYVISVDKNAPLEKVAPLLCAGITTYSPLK-FSKVTKGTKVGV 182 Query: 187 LGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLD 246 G GG+G M VK A AMG V+V + + K+++AL +G + Q K + LD Sbjct: 183 AGFGGLGSMAVKYAVAMGAEVSVFARNEHKKQDALS-MGVKHFYTDPKQCK-----EELD 236 Query: 247 YVIDTVPVHHALEPYLSLLKLDGKLILMG---VINNPLQFLTPLLMLGRKVITGSFIGSM 303 ++I T+P H+ L+ YL LL +G L L+G V P+ + + LG + + GS IG + Sbjct: 237 FIISTIPTHYDLKDYLKLLTYNGDLALVGLPPVEVAPVLSVFDFIHLGNRKVYGSLIGGI 296 Query: 304 KETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGS 353 KET+EM++F + + I+++ ++TA+ L ++R+V+D++ S Sbjct: 297 KETQEMVDFSIKHNIYPEIDLILGKDIDTAYHNLTHGKAKFRYVIDMKKS 346 >4OAQ-A nrPDB Length = 367 Score = 202 bits (513), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 129/352 (36%), Positives = 195/352 (55%), Gaps = 14/352 (3%) Query: 9 KTTGWAARDPSGILSP--YTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLG-MSNYPM 65 K G+A DP P +Y ++ P DV ++ CG+C++D+H + + Sbjct: 8 KFQGFAVSDPKNWNRPKLASYERKQINPHDVVLKNEVCGLCYSDIHTLSAGWQPLQRDNL 67 Query: 66 VPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYN--D 123 V GHE++GEV+ VG +V++F VGD VG+G C C C+ D EQYC + +YN D Sbjct: 68 VVGHEIIGEVIAVGDEVTEFKVGDRVGIGAASSSCRSCQRCDSDNEQYCKQGAATYNSKD 127 Query: 124 VYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPL-SHFGLKQPGL 182 V N TQGG++ ++ +KFV IPE + APL+CAG+TV+SPL + GL G Sbjct: 128 VRSNNYVTQGGYSSHSIADEKFVFAIPEDLPSSYGAPLMCAGITVFSPLIRNLGLDARGK 187 Query: 183 RGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYV-IGSDQAKMSEL 241 GI+G+GG+GH+ ++ A AMG +VT S S+ K+E+A++ LGA D+V G D+ Sbjct: 188 NVGIIGIGGLGHLALQFANAMGANVTAFSRSSSKKEQAMK-LGAHDFVATGEDKTWYKNY 246 Query: 242 ADSLDYVIDTVPVHHALE--PYLSLLKLDGKLILMGVINNPLQF-LTPLLMLGRKVITG- 297 D D++++ L YLS LK+D K + +G+ + +F ++P L + G Sbjct: 247 DDHFDFILNCASGIDGLNLSEYLSTLKVDKKFVSVGLPPSEDKFEVSPFTFLQQGASFGS 306 Query: 298 SFIGSMKETEEMLEFCKEKGLSSIIEVVKMDYVN--TAFERLEKNDVRYRFV 347 S +GS E +EML + + +IE V + N A +R DVRYRFV Sbjct: 307 SLLGSKTEVKEMLNLAAKHNVRPMIEEVPISEENCAKALDRCHAGDVRYRFV 358 >1Q1N-A nrPDB Length = 360 Score = 182 bits (461), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 125/324 (38%), Positives = 187/324 (57%), Gaps = 18/324 (5%) Query: 36 DVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDV-SKFTVGDIVGVG 94 D++I+I CG+C +D+H G P+V GHE+VG+VV++G S VG VGVG Sbjct: 35 DIDIKIEACGVCGSDIHCAAGHWGNMKMPLVVGHEIVGKVVKLGPKSNSGLKVGQRVGVG 94 Query: 95 CLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMA 154 V C C C+ D E YC K + +Y+ Y +G +QGG+A VH+ FVV IPE + Sbjct: 95 AQVFSCLECDRCKNDNEPYCTKFVTTYSQPYEDGYVSQGGYANYVRVHEHFVVPIPENIP 154 Query: 155 VEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSN 214 AAPLLC G+TVYSPL G PG + GI+GLGG+G MG I+KAMG VIS S+ Sbjct: 155 SHLAAPLLCGGLTVYSPLVRNGC-GPGKKVGIVGLGGIGSMGTLISKAMGAETYVISRSS 213 Query: 215 KKREEALQDLGADDYVIGSDQAKMSE-LADSLDYVI----DTVPVHHALEPYLSLLKLDG 269 +KRE+A++ +GAD Y+ ++ E D+ D ++ + + P +K+ G Sbjct: 214 RKREDAMK-MGADHYIATLEEGDWGEKYFDTFDLIVVCASSLTDIDFNIMP--KAMKVGG 270 Query: 270 KLILMGVINNPLQF-LTPLLMLGRKVITGSF--IGSMKETEEMLEFCKEKGLSSIIEVVK 326 +++ + + P Q + L G K ++ S+ +GS+KE ++L+ EK + +E + Sbjct: 271 RIVSISI---PEQHEMLSLKPYGLKAVSISYSALGSIKELNQLLKLVSEKDIKIWVETLP 327 Query: 327 MDY--VNTAFERLEKNDVRYRFVV 348 + V+ AFER+EK DVRYRF + Sbjct: 328 VGEAGVHEAFERMEKGDVRYRFTL 351 >3PII-A nrPDB Length = 339 Score = 169 bits (429), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 114/322 (35%), Positives = 169/322 (52%), Gaps = 17/322 (5%) Query: 36 DVNIRIICCGICHTDLHQTKNDLGMS-NYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVG 94 +V +RI CG+CHTDLH D + P++PGHE VG V EVG V+ VGD VG+ Sbjct: 27 EVLVRIKACGVCHTDLHAAHGDWPVKPKLPLIPGHEGVGIVEEVGPGVTHLKVGDRVGIP 86 Query: 95 CLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMA 154 L CG C C E C + + G GG+A+ +VVKIP+ ++ Sbjct: 87 WLYSACGHCDYCLSGQETLCEHQKNA-------GYSVDGGYAEYCRAAADYVVKIPDNLS 139 Query: 155 VEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSN 214 E+AAP+ CAGVT Y L G K PG I G+GG GH+ V+ AKAMG +V + + Sbjct: 140 FEEAAPIFCAGVTTYKALKVTGAK-PGEWVAIYGIGGFGHVAVQYAKAMGLNVVAVDIGD 198 Query: 215 KKREEALQDLGADDYV--IGSDQAK-MSELADSLDYVIDTVPVHHALEPYLSLLKLDGKL 271 +K E A ++LGAD V + D AK M E + + T A + + ++ G Sbjct: 199 EKLELA-KELGADLVVNPLKEDAAKFMKEKVGGVHAAVVTAVSKPAFQSAYNSIRRGGAC 257 Query: 272 ILMGVINNPLQFLTPLL--MLGRKVITGSFIGSMKETEEMLEFCKEKGLSSIIEVVKMDY 329 +L+G+ P + P+ +L I GS +G+ K+ +E L+F E + +IIEV ++ Sbjct: 258 VLVGL--PPEEMPIPIFDTVLNGIKIIGSIVGTRKDLQEALQFAAEGKVKTIIEVQPLEK 315 Query: 330 VNTAFERLEKNDVRYRFVVDVE 351 +N F+R+ K + R V+ +E Sbjct: 316 INEVFDRMLKGQINGRVVLTLE 337 >6C49-A nrPDB Length = 350 Score = 159 bits (403), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 108/340 (31%), Positives = 167/340 (49%), Gaps = 8/340 (2%) Query: 12 GWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEV 71 +AA L PY + E P V +++ CG+CH+D+ N+ + YP+V GHE+ Sbjct: 16 AYAAMQAGEKLVPYKFDAGELQPHQVEVKVEYCGLCHSDISVLNNEWHSTVYPVVAGHEI 75 Query: 72 VGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPT 131 +G +V +GS+ +G VG+G C C C + C + N I G Sbjct: 76 IGRIVALGSEAKGLQIGQRVGIGWTAESCQACDECIGGQQVLCTGE----NIATIVGH-- 129 Query: 132 QGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGG 191 GGFA ++ + +PE + E A PLLC G+TV+ PL + Q G++G+GG Sbjct: 130 AGGFADKVRAGWQWAIPLPEDLDPESAGPLLCGGITVFDPLLKHKI-QATHHVGVIGIGG 188 Query: 192 VGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDYVIDT 251 +GH+ +K+ KA G +T SS+ K EE L+ +GAD V D + D ++ T Sbjct: 189 LGHIAIKLLKAWGCEITAFSSNPDKTEE-LKAMGADHVVNSRDTEAVKAQKGKFDLLLST 247 Query: 252 VPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLE 311 V V ++S L +G L +G+ P+ L+ G K +TGS GS ++L+ Sbjct: 248 VNVTLNWRAFISTLAPNGSLHFLGLTLEPVPVSVGSLIDGAKSVTGSPTGSPAALRQLLK 307 Query: 312 FCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVE 351 F K ++ IE+ M +N A ERL RYR V+ + Sbjct: 308 FAARKKIAPQIELFPMSQLNEAIERLHSGQARYRIVLKAD 347 >6N7L-A nrPDB Length = 353 Score = 155 bits (393), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 107/339 (31%), Positives = 165/339 (48%), Gaps = 32/339 (9%) Query: 29 LRETGPEDVNIRIICCGICHTDLHQTKNDL-GMSNYPMVPGHEVVGEVVEVGSDVSKFTV 87 +RE G +V ++++ CG+CHTDLH D P++PGHE VG VV G D + Sbjct: 33 VREPGRYEVLVKVMACGVCHTDLHAVDGDWPAKPKMPLIPGHEGVGIVVACGPD-AMVKE 91 Query: 88 GDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVV 147 GD VGV L CG C C E C + G GGFA+ + ++V Sbjct: 92 GDAVGVPWLYSACGCCDYCITGWETLCEAQ-------QNGGYSVDGGFAEYVIADSRYVG 144 Query: 148 KIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHV 207 + + + AP+LCAGVTVY L K PG I G+GG+GH+ V+ AKAMG HV Sbjct: 145 HLKSNVNFLEIAPILCAGVTVYKGLKETETK-PGEWVAISGIGGLGHVAVQYAKAMGMHV 203 Query: 208 TVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDYVIDTVPVHH----------A 257 I ++ K E A + +G+D ++ D Y+ V H A Sbjct: 204 AAIDVADDKLELAKK--------LGADLTVNAKTTDPGTYLHKEVGGMHGALITAVSPIA 255 Query: 258 LEPYLSLLKLDGKLILMGVINNPLQFLTPLL--MLGRKVITGSFIGSMKETEEMLEFCKE 315 + + +L+ G + L G+ P F P+ +L R + GS +G+ K+ +E L+F E Sbjct: 256 FKQGIDVLRRKGTIALNGL--PPGSFELPIFETVLKRITVRGSIVGTRKDLQEALDFANE 313 Query: 316 KGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGSN 354 + + + K++ +N F++++K + R V+D+ GS Sbjct: 314 GLVKATVTSAKLEDINDVFDKMKKGQIDGRIVLDIAGSQ 352 >3S2F-A nrPDB Length = 340 Score = 149 bits (376), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 109/329 (33%), Positives = 158/329 (48%), Gaps = 25/329 (7%) Query: 31 ETGPEDVNIRIICCGICHTDLHQTKNDLGMS-NYPMVPGHEVVGEVVEVGSDVSKFTVGD 89 + GP V ++I G+CHTDLH D + P +PGHE VG V VGS VS+ GD Sbjct: 24 QPGPGQVQVKIEASGVCHTDLHAADGDWPVKPTLPFIPGHEGVGYVSAVGSGVSRVKEGD 83 Query: 90 IVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKI 149 VGV L CG C C + E C K+ G GG+ + V +V + Sbjct: 84 RVGVPWLYSACGYCEHCLQGWETLCEKQ-------QNTGYSVNGGYGEYVVADPNYVGLL 136 Query: 150 PEGMAVEQAAPLLCAGVTVYSPLSHFGLK----QPGLRGGILGLGGVGHMGVKIAKAMGH 205 P+ + + AP+LCAGVTVY GLK +PG I G+GG+GH+ V+ A+AMG Sbjct: 137 PDKVGFVEIAPILCAGVTVYK-----GLKVTDTRPGQWVVISGIGGLGHVAVQYARAMGL 191 Query: 206 HVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSL---DYVIDTVPVHHALEPYL 262 V + + K A + LGA+ V D + L + V+ T A + Sbjct: 192 RVAAVDIDDAKLNLA-RRLGAEVAVNARDTDPAAWLQKEIGGAHGVLVTAVSPKAFSQAI 250 Query: 263 SLLKLDGKLILMGVINNPLQFLTPLLMLGRKVIT--GSFIGSMKETEEMLEFCKEKGLSS 320 +++ G + L G+ P F TP+ + K IT GS +G+ + +E L+F + + Sbjct: 251 GMVRRGGTIALNGL--PPGDFGTPIFDVVLKGITIRGSIVGTRSDLQESLDFAAHGDVKA 308 Query: 321 IIEVVKMDYVNTAFERLEKNDVRYRFVVD 349 + K+D VN F RL + V R V+D Sbjct: 309 TVSTAKLDDVNDVFGRLREGKVEGRVVLD 337 >3MEQ-A nrPDB Length = 365 Score = 145 bits (365), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 108/364 (29%), Positives = 173/364 (47%), Gaps = 23/364 (6%) Query: 1 MGIMEAERKTTGWAARDPSGIL-----SPYT---YTLRETGPEDVNIRIICCGICHTDLH 52 MG +EA+ + G A+ + P T + + GP + + I G+CHTDLH Sbjct: 9 MGTLEAQTQGPGSMAKTMKAAVVRAFGKPLTIDEVPIPQPGPGQIQVAIQASGVCHTDLH 68 Query: 53 QTKNDLGMS-NYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLE 111 + D + N P +PGHE VG V VGS V GD VG+ L CG C C E Sbjct: 69 AAEGDWPVKPNPPFIPGHEGVGFVSAVGSGVKHVKEGDRVGIPWLYTACGHCRHCLGGWE 128 Query: 112 QYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSP 171 C +++ + G GGFA+ V FV +P+ + + AP+LCAGVTVY Sbjct: 129 TLCEEQLNT-------GYSVNGGFAEYVVADPNFVGHLPKNIDFNEIAPVLCAGVTVYKG 181 Query: 172 LSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGA----D 227 L K PG I G+GG+GHM V+ A+AMG +V + ++K + A + LGA + Sbjct: 182 LKVTDTK-PGDWVVISGIGGLGHMAVQYARAMGLNVAAVDIDDRKLDLA-RRLGATVTVN 239 Query: 228 DYVIGSDQAKMSELAD-SLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTP 286 + A + + D V+ T A E L ++ G + L G+ Sbjct: 240 AKTVADPAAYIRKETDGGAQGVLVTAVSPKAFEQALGMVARGGTVSLNGLPPGDFPLSIF 299 Query: 287 LLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRF 346 ++L + GS +G+ + +E L+F + + + I+ K++ +N F+ + + ++ R Sbjct: 300 NMVLNGVTVRGSIVGTRLDLQESLDFAADGKVKATIQTGKLEDINAIFDDMRQGNIEGRI 359 Query: 347 VVDV 350 V+D+ Sbjct: 360 VMDL 363 >1LLU-A nrPDB Length = 342 Score = 142 bits (357), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 103/328 (31%), Positives = 159/328 (48%), Gaps = 25/328 (7%) Query: 33 GPEDVNIRIICCGICHTDLHQTKNDLGMSN-YPMVPGHEVVGEVVEVGSDVSKFTVGDIV 91 GP V ++I G+CHTDLH + D + P +PGHE VG V VGS V++ GD V Sbjct: 30 GPGQVLVKIEASGVCHTDLHAAEGDWPVKPPLPFIPGHEGVGYVAAVGSGVTRVKEGDRV 89 Query: 92 GVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPE 151 G+ L CG C C E C + G GG+A+ + +V +P+ Sbjct: 90 GIPWLYTACGCCEHCLTGWETLCESQ-------QNTGYSVNGGYAEYVLADPNYVGILPK 142 Query: 152 GMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGG----ILGLGGVGHMGVKIAKAMGHHV 207 + + AP+LCAGVTVY GLKQ R G I G+GG+GH+ V+ A+AMG HV Sbjct: 143 NVEFAEIAPILCAGVTVYK-----GLKQTNARPGQWVAISGIGGLGHVAVQYARAMGLHV 197 Query: 208 TVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSL---DYVIDTVPVHHALEPYLSL 264 I + K E A + LGA V + + + + V+ T + A + + Sbjct: 198 AAIDIDDAKLELA-RKLGASLTVNARQEDPVEAIQRDIGGAHGVLVTAVSNSAFGQAIGM 256 Query: 265 LKLDGKLILMGVINNPLQFLTPLL--MLGRKVITGSFIGSMKETEEMLEFCKEKGLSSII 322 + G + L+G+ P F TP+ +L I GS +G+ + +E L+F E + + I Sbjct: 257 ARRGGTIALVGL--PPGDFPTPIFDVVLKGLHIAGSIVGTRADLQEALDFAGEGLVKATI 314 Query: 323 EVVKMDYVNTAFERLEKNDVRYRFVVDV 350 K+D +N +++ + R V+++ Sbjct: 315 HPGKLDDINQILDQMRAGQIEGRIVLEM 342 >4EEZ-A nrPDB Length = 348 Score = 137 bits (346), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 93/338 (27%), Positives = 153/338 (45%), Gaps = 14/338 (4%) Query: 17 DPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVV 76 +P G LR P + + + CG+CHTDLH D G + V GHE +G V Sbjct: 9 NPDGYADLVEKELRAIKPNEALLDMEYCGVCHTDLHVAAGDFG-NKAGTVLGHEGIGIVK 67 Query: 77 EVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFA 136 E+G+DVS VGD V V CG C C E +C +V G GG A Sbjct: 68 EIGADVSSLQVGDRVSVAWFFEGCGHCEYCVSGNETFC-------REVKNAGYSVDGGMA 120 Query: 137 KATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMG 196 + +V + VK+P+G+ +A+ + CAGVT Y + G+K PG I G GG+G++ Sbjct: 121 EEAIVVADYAVKVPDGLDPIEASSITCAGVTTYKAIKVSGVK-PGDWQVIFGAGGLGNLA 179 Query: 197 VKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELAD-----SLDYVIDT 251 ++ AK + + N+ + + +GAD + D + E+ + I Sbjct: 180 IQYAKNVFGAKVIAVDINQDKLNLAKKIGADVTINSGDVNPVDEIKKITGGLGVQSAIVC 239 Query: 252 VPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLE 311 A E ++ LK GK++ + V N + P ++ + GS +G+ + E + Sbjct: 240 AVARIAFEQAVASLKPMGKMVAVAVPNTEMTLSVPTVVFDGVEVAGSLVGTRLDLAEAFQ 299 Query: 312 FCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVD 349 F E + I+ K++ +N + ++ + R V+D Sbjct: 300 FGAEGKVKPIVATRKLEEINDIIDEMKAGKIEGRMVID 337 >4Z6K-A nrPDB Length = 346 Score = 132 bits (331), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 102/327 (31%), Positives = 155/327 (47%), Gaps = 25/327 (7%) Query: 33 GPEDVNIRIICCGICHTDLHQTKNDLGMS-NYPMVPGHEVVGEVVEVGSDVSKFTVGDIV 91 G ++ +++ G+CHTDLH + D + + P +PGHE VG + VG V+ GD V Sbjct: 24 GAGEIVVKMQASGVCHTDLHAVEGDWPVKPSPPFIPGHEGVGLITAVGEGVTHVKEGDRV 83 Query: 92 GVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPE 151 GV L CG C+ C E C + S G G FA+ + + +V IPE Sbjct: 84 GVAWLYSACGHCTHCLGGWETLCESQQNS-------GYSVNGSFAEYVLANANYVGIIPE 136 Query: 152 GMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVIS 211 + + AP+LCAGVTVY L K PG I G+GG+GHM V+ A AMG +V + Sbjct: 137 SVDSIEIAPVLCAGVTVYKGLKMTDTK-PGDWVVISGIGGLGHMAVQYAIAMGLNVAAVD 195 Query: 212 SSNKKREEALQDLGADDYVIGSDQAKMSELADSLDYVID-------TVPVHHALEPYLSL 264 + K A + LGA V AK ++ A+ L I T A + LS+ Sbjct: 196 IDDDKLAFA-KKLGAKVTV----NAKNTDPAEYLQKEIGGAHGALVTAVSAKAFDQALSM 250 Query: 265 LKLDGKLILMGVINNPLQFLTPLL--MLGRKVITGSFIGSMKETEEMLEFCKEKGLSSII 322 L+ G L+ G+ P F + +L I GS +G+ + +E L+ + + + Sbjct: 251 LRRGGTLVCNGL--PPGDFPVSIFDTVLNGITIRGSIVGTRLDLQESLDMAAAGKVKATV 308 Query: 323 EVVKMDYVNTAFERLEKNDVRYRFVVD 349 ++ +N FER+ + + R V+D Sbjct: 309 TAEPLENINDIFERMRQGKIEGRIVID 335 >5ENV-A nrPDB Length = 347 Score = 125 bits (315), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 93/327 (28%), Positives = 146/327 (44%), Gaps = 33/327 (10%) Query: 39 IRIICCGICHTDLHQTKNDLGMS-NYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLV 97 I + G+CHTDLH D + P+V GHE G VV +G +V + +GD G+ L Sbjct: 35 INVKYSGVCHTDLHAWHGDWPLPVKLPLVGGHEGAGVVVGMGENVKGWKIGDYAGIKWLN 94 Query: 98 GCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQ 157 G C C CE E CP ++G G F + IP+G + Q Sbjct: 95 GSCMACEYCELGNESNCPH-------ADLSGYTHDGSFQQYATADAVQAAHIPQGTDLAQ 147 Query: 158 AAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKR 217 AP+LCAG+TVY L L GG+G + V+ AKAMG+ V I K Sbjct: 148 VAPILCAGITVYKALKSANLMAGHWVAISGAAGGLGSLAVQYAKAMGYRVLGIDGGEGK- 206 Query: 218 EEALQDLGADDYVIGSDQ-----AKMSELADSLDYVIDTVPVHHALEPYLSLLKLDGKLI 272 EE + +G + ++ + + A + VI+ A+E ++ +G + Sbjct: 207 EELFRSIGGEVFIDFTKEKDIVGAVLKATDGGAHGVINVSVSEAAIEASTRYVRANGTTV 266 Query: 273 LMG----------VINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSSII 322 L+G V N ++ ++ I GS++G+ +T E L+F + S I Sbjct: 267 LVGMPAGAKCCSDVFNQVVKSIS---------IVGSYVGNRADTREALDFFARGLVKSPI 317 Query: 323 EVVKMDYVNTAFERLEKNDVRYRFVVD 349 +VV + + +E++EK + R+VVD Sbjct: 318 KVVGLSTLPEIYEKMEKGQIVGRYVVD 344 >2EER-A nrPDB Length = 347 Score = 111 bits (277), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 91/318 (28%), Positives = 145/318 (45%), Gaps = 26/318 (8%) Query: 37 VNIRIICCGICHTDLHQTK---------NDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTV 87 V I+I G+CH+D+H + DLG+ P+ GHE+ G + EVG +V ++ Sbjct: 28 VLIKIEAAGVCHSDVHMRQGRFGNLRIVEDLGV-KLPVTLGHEIAGRIEEVGDEVVGYSK 86 Query: 88 GDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVV-HQKFV 146 GD+V V G G C C E C W G G +A+ +V H K++ Sbjct: 87 GDLVAVNPWEG-EGNCYYCRIGEEHLCDSPRWL-------GINYDGAYAEYVLVPHYKYL 138 Query: 147 VKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHH 206 K+ AVE AAPL C+GVT Y + L I GG+G M ++IAKA+ Sbjct: 139 YKLRRLSAVE-AAPLTCSGVTTYRAVRKASLDPSKTLVVIGAGGGLGTMAIQIAKAVSGA 197 Query: 207 VTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL-----ADSLDYVIDTVPVHHALEPY 261 + ++ EA + GAD + S Q +SE+ D VID L Y Sbjct: 198 TIIGVDVREEALEAAKRAGADYVINASSQDPVSEIRRITQGKGADAVIDLNNSEKTLSIY 257 Query: 262 LSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSSI 321 +L GK +++G+ L++ PL+ L GS +G+ + ++ + + + Sbjct: 258 PYVLAKQGKYVMVGLFGADLKYHAPLITLNEVQFIGSLVGNQSDFLGIMSLAEAGKVKPM 317 Query: 322 I-EVVKMDYVNTAFERLE 338 + + +K++ N A + LE Sbjct: 318 VTKTMKLEEANEAIDNLE 335 >5YAT-A nrPDB Length = 350 Score = 108 bits (270), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 86/318 (27%), Positives = 154/318 (48%), Gaps = 15/318 (4%) Query: 39 IRIICCGICHTDLHQTKNDLGMSN-YPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLV 97 I + G+CHTDLH K D + N P+V GHE G VV G +V+ + +GD G+ L Sbjct: 38 INVKYSGVCHTDLHAWKGDWPLDNKLPLVGGHEGAGVVVAYGENVTGWEIGDYAGIKWLN 97 Query: 98 GCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQ 157 G C C C + E C K ++G G F + +IP+ + + Sbjct: 98 GSCLNCEYCIQGAESSCAK-------ADLSGFTHDGSFQQYATADATQAARIPKEADLAE 150 Query: 158 AAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKR 217 AP+LCAG+TVY L L+ GG+G + V+ AKA+G V I K Sbjct: 151 VAPILCAGITVYKALKTADLRIGQWVAISGAGGGLGSLAVQYAKALGLRVLGIDGGADKG 210 Query: 218 EEALQDLGADDYVIGSDQ----AKMSELADSLDYVIDTVPVH-HALEPYLSLLKLDGKLI 272 E ++ LGA+ +V + A++ +L + + + V V HA+ + ++ GK++ Sbjct: 211 -EFVKSLGAEVFVDFTKTKDVVAEVQKLTNGGPHGVINVSVSPHAINQSVQYVRTLGKVV 269 Query: 273 LMGVINNPLQFLTPLLMLGRKV-ITGSFIGSMKETEEMLEFCKEKGLSSIIEVVKMDYVN 331 L+G+ + + + + + I GS++G+ +++ E ++ + + I+++ + + Sbjct: 270 LVGLPSGAVVNSDVFWHVLKSIEIKGSYVGNREDSAEAIDLFTRGLVKAPIKIIGLSELA 329 Query: 332 TAFERLEKNDVRYRFVVD 349 +E++E + R+VVD Sbjct: 330 KVYEQMEAGAIIGRYVVD 347 >4GKV-A nrPDB Length = 336 Score = 107 bits (268), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 92/329 (27%), Positives = 152/329 (46%), Gaps = 15/329 (4%) Query: 26 TY-TLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSK 84 TY TLR + +++ CCG+CHTDLH D G ++ GHE +G V EVG V+ Sbjct: 15 TYKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFG-DKTGVILGHEGIGVVAEVGPGVTS 73 Query: 85 FTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQK 144 GD V CG C C E C V G GG A+ +V Sbjct: 74 LKPGDRASVAWFYEGCGHCEYCNSGNETLC-------RSVKNAGYSVDGGMAEECIVVAD 126 Query: 145 FVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMG 204 + VK+P+G+ A+ + CAGVT Y + ++ PG I GLGG+G++ ++ AK + Sbjct: 127 YAVKVPDGLDSAAASSITCAGVTTYKAVKLSKIR-PGQWIAIYGLGGLGNLALQYAKNVF 185 Query: 205 HHVTVISSSNKKREEALQDLGADDYVIGS---DQAKM-SELADSLDYVIDTVPVHHALEP 260 + + N ++ + ++GAD I S D AK+ E + T A Sbjct: 186 NAKVIAIDVNDEQLKLATEMGAD-LAINSHTEDAAKIVQEKTGGAHAAVVTAVAKAAFNS 244 Query: 261 YLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSS 320 + ++ G+++ +G+ + P L+L + GS +G+ ++ E +F E + Sbjct: 245 AVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEGKVVP 304 Query: 321 IIEVVKMDYVNTAFERLEKNDVRYRFVVD 349 + + + +NT F +E+ +R R V+D Sbjct: 305 KVALRPLADINTIFTEMEEGKIRGRMVID 333 >1H2B-A nrPDB Length = 359 Score = 107 bits (266), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 95/335 (28%), Positives = 157/335 (46%), Gaps = 30/335 (8%) Query: 30 RETGPEDVNIRIICCGICHTDLHQTK---NDLGMSNYPMVPGHEVVGEVVEVGSDVSKFT 86 R G DV +RI G+CHTDLH + ++L P GHE VG + EV V Sbjct: 37 RLEGRFDVIVRIAGAGVCHTDLHLVQGMWHELLQPKLPYTLGHENVGYIEEVAEGVEGLE 96 Query: 87 VGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFV 146 GD V + V G C C + +C ++ G GGFA+ + V Sbjct: 97 KGDPVILHPAV-TDGTCLACRAGEDMHC-------ENLEFPGLNIDGGFAEFMRTSHRSV 148 Query: 147 VKIPEGMAVE---QAAPLLCAGVTVYSPLSHFGLK-QPGLRGGILGLGGVGHMGVKIAKA 202 +K+P+ ++ E + APL AG+T Y + PG I+G+GG+GH+ V++ K Sbjct: 149 IKLPKDISREKLVEMAPLADAGITAYRAVKKAARTLYPGAYVAIVGVGGLGHIAVQLLKV 208 Query: 203 MGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELAD---------SLDYVIDTVP 253 M TVI+ K+ + L + D+V+ + + + ++ + ++D+V Sbjct: 209 MTP-ATVIALDVKEEKLKLAERLGADHVVDARRDPVKQVMELTRGRGVNVAMDFVGSQAT 267 Query: 254 VHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFC 313 V + PYL L G+LI++G L+F T ++ GS +G+ E E++ Sbjct: 268 VDYT--PYL--LGRMGRLIIVG-YGGELRFPTIRVISSEVSFEGSLVGNYVELHELVTLA 322 Query: 314 KEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVV 348 + + +++ K+D +N ERLEK +V R V+ Sbjct: 323 LQGKVRVEVDIHKLDEINDVLERLEKGEVLGRAVL 357 >1R37-A nrPDB Length = 347 Score = 105 bits (263), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 91/325 (28%), Positives = 150/325 (46%), Gaps = 27/325 (8%) Query: 30 RETGPEDVNIRIICCGICHTDLHQTK---------NDLGMSNYPMVPGHEVVGEVVEVGS 80 + GP+ V I++ G+CH+D+H + DLG+ P+ GHE+ G++ EVG Sbjct: 22 KPKGPQ-VLIKVEAAGVCHSDVHMRQGRFGNLRIVEDLGV-KLPVTLGHEIAGKIEEVGD 79 Query: 81 DVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATV 140 +V ++ GD+V V G G C C E C W G G +A+ + Sbjct: 80 EVVGYSKGDLVAVNPWQG-EGNCYYCRIGEEHLCDSPRWL-------GINFDGAYAEYVI 131 Query: 141 V-HQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKI 199 V H K++ K+ AVE AAPL C+G+T Y + L + GG+G M V+I Sbjct: 132 VPHYKYMYKLRRLNAVE-AAPLTCSGITTYRAVRKASLDPTKTLLVVGAGGGLGTMAVQI 190 Query: 200 AKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL-----ADSLDYVIDTVPV 254 AKA+ + ++ EA + GAD + S Q ++E+ + +D VID Sbjct: 191 AKAVSGATIIGVDVREEAVEAAKRAGADYVINASMQDPLAEIRRITESKGVDAVIDLNNS 250 Query: 255 HHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCK 314 L Y L GK +++G+ L + PL+ L GS +G+ + ++ + Sbjct: 251 EKTLSVYPKALAKQGKYVMVGLFGADLHYHAPLITLSEIQFVGSLVGNQSDFLGIMRLAE 310 Query: 315 EKGLSSII-EVVKMDYVNTAFERLE 338 + +I + +K++ N A + LE Sbjct: 311 AGKVKPMITKTMKLEEANEAIDNLE 335 >6FG0-A nrPDB Length = 352 Score = 103 bits (258), Expect = 8e-23, Method: Compositional matrix adjust. Identities = 91/331 (27%), Positives = 154/331 (46%), Gaps = 26/331 (7%) Query: 33 GPEDVNIRIICCGICHTDLHQTKNDLGMSNY----PMVPGHEVVGEVVEVGSDVSKFTVG 88 GP ++ +++ G+CH+D+ T D+ + Y P+ GHE VG V E+G V+ F VG Sbjct: 24 GPGEILLKVTAAGLCHSDI--TVMDMPAAQYAGGLPLTLGHEGVGTVAELGEGVTGFGVG 81 Query: 89 DIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYIN--GQPTQGGFAKATVVHQ-KF 145 D V V G CG C C R E YC + D+ I G + G A+ +V + Sbjct: 82 DAVAVYGPWG-CGACHACARGRENYCTRA----ADLGITPPGYGSPGSMAEYMIVDSARH 136 Query: 146 VVKIPEGMAVEQAAPLLCAGVTVYSPLSH-FGLKQPGLRGGILGLGGVGHMGVKIAKAMG 204 +V I + + AAPL AG+T Y +S L PG ++G+GG+GH+G++I +A+ Sbjct: 137 LVPIGD-LDPVAAAPLTDAGLTPYHAISRVLPLLGPGSTAVVIGVGGLGHVGIQILRAVS 195 Query: 205 HHVTVISSSNKKREEALQDLGADDYVI----GSDQAKMSELADSLDYVIDTVPVHHALEP 260 + + R +++GAD V +D + V D V ++ Sbjct: 196 AARVIAVDLDDDRLALAREVGADAAVKSGAGAADAIRELTGGQGATAVFDFVGAQSTIDT 255 Query: 261 YLSLLKLDGKLILMGV---INNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKG 317 ++ +DG + ++G+ + + F ++ G V+T + G+ E E++ + Sbjct: 256 AQQVVAVDGHISVVGIHAGAHAKVGFW--MIPFGASVVT-PYWGTRSELMEVVALARAGR 312 Query: 318 LSSIIEVVKMDYVNTAFERLEKNDVRYRFVV 348 L E +D A+ RL + +R R VV Sbjct: 313 LDIHTETFTLDEGPAAYRRLREGSIRGRGVV 343 >5K1S-A nrPDB Length = 362 Score = 98.2 bits (243), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 86/339 (25%), Positives = 155/339 (45%), Gaps = 19/339 (5%) Query: 19 SGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEV 78 +G L T + G +V +R+ CG+C+ D+ + +L ++ P + GHE GEV+EV Sbjct: 29 AGNLKMETMPMPRPGRGEVLLRVHACGVCYHDVINRRGNLPRTSVPAILGHEAAGEVIEV 88 Query: 79 GSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKA 138 G D + GD + CG C+ C C D G+ GG+A+ Sbjct: 89 GPDTPGWKTGDRAATLQRM-SCGDCALCRSGRNSLC------KTDNRFFGEELPGGYAQF 141 Query: 139 TVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGL-GGVGHMGV 197 V + ++P + +AA + C T + G + G I G GGVG V Sbjct: 142 MVAPVGGLGRVPASLPWNEAATVCCTTGTAVHTVRTRGKVRAGETVLITGASGGVGLSSV 201 Query: 198 KIAKAMGHHVTVISSSNKKREEALQDLGADDYVI------GSDQAKMSELADSLDYVIDT 251 ++A+ G V ++SS K +AL++ GAD+ ++ SD K ++ A +D ++ Sbjct: 202 QLARLDGARVIAVTSSEAK-VQALKEAGADEVIVSRGLDFASDVRKRTQGA-GVDVAVEI 259 Query: 252 VPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKV-ITGSFIGSMKETEEML 310 V + L + G+++++G + + + L P L++ +++ I G++ + E +E L Sbjct: 260 VG-SATFDQTLKSMAPGGRVVVVGNLESGMVQLNPGLVIVKELEILGAYATTQAELDEAL 318 Query: 311 EFCKEKGLSSII-EVVKMDYVNTAFERLEKNDVRYRFVV 348 G+ + + V + A RLE +V R V+ Sbjct: 319 RLTATGGVRQFVTDAVPLAEAAKAHFRLENREVAGRLVL 357 >2H6E-A nrPDB Length = 344 Score = 91.3 bits (225), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 99/326 (30%), Positives = 153/326 (46%), Gaps = 24/326 (7%) Query: 35 EDVNIRIICCGICHTDLHQTKNDLGMSNY--PMVPGHEVVGEVVEVGSDVSKFTVGDIVG 92 E+V IRI G+C TDL K + P++ GHE G +VEVG +++K GD V Sbjct: 29 EEVLIRIGGAGVCRTDLRVWKGVEAKQGFRLPIILGHENAGTIVEVG-ELAKVKKGDNVV 87 Query: 93 VGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVH-QKFVVKIPE 151 V G C C C +I I GQ T GGF++ +V +++VK+ Sbjct: 88 VYATWGDLT-CRYCREGKFNICKNQI-------IPGQTTNGGFSEYMLVKSSRWLVKLNS 139 Query: 152 GMAVEQAAPLLCAGVTVYSPLSH---FGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVT 208 VE AAPL AG T + F K + G+GG+ ++I KA+ ++T Sbjct: 140 LSPVE-AAPLADAGTTSMGAIRQALPFISKFAEPVVIVNGIGGLAVYTIQILKALMKNIT 198 Query: 209 V--ISSSNKKREEALQDLGADDYV--IGSDQAKMSELADSL--DYVIDTVPVHHALEPYL 262 + IS S K R+ AL+ LGA DYV + ++ +++L D L ID V Sbjct: 199 IVGISRSKKHRDFALE-LGA-DYVSEMKDAESLINKLTDGLGASIAIDLVGTEETTYNLG 256 Query: 263 SLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSSII 322 LL +G +IL+G+ + + K + GS GS+ + E+++ + + I Sbjct: 257 KLLAQEGAIILVGMEGKRVSLEAFDTAVWNKKLLGSNYGSLNDLEDVVRLSESGKIKPYI 316 Query: 323 EVVKMDYVNTAFERLEKNDVRYRFVV 348 V +D +N AF L++ V R V+ Sbjct: 317 IKVPLDDINKAFTNLDEGRVDGRQVI 342 >2DFV-A nrPDB Length = 347 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 80/256 (31%), Positives = 120/256 (46%), Gaps = 27/256 (10%) Query: 33 GPEDVNIRIICCGICHTDLHQTK-NDLGMSNY--PMVPGHEVVGEVVEVGSDVSKFTVGD 89 GP +V I+++ IC TDLH + N+ S P + GHEV GEVVE+G V VGD Sbjct: 27 GPGEVLIKVLATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEIGPGVEGIEVGD 86 Query: 90 IVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKI 149 V V + CG C C R C + I G T G FA+ VV + + K Sbjct: 87 YVSVETHI-VCGKCYACRRGQYHVC-------QNTKIFGVDTDGVFAEYAVVPAQNIWKN 138 Query: 150 PEGMAVEQAA---PLLCAGVTVYS-PLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGH 205 P+ + E A PL A TV + P+S G I G G +G +G+ +AKA G Sbjct: 139 PKSIPPEYATLQEPLGNAVDTVLAGPIS-------GKSVLITGAGPLGLLGIAVAKASGA 191 Query: 206 HVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELAD-----SLDYVIDTVPVHHALEP 260 + ++S + R E + +GAD + ++ + E+ D +D ++ ALE Sbjct: 192 YPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQ 251 Query: 261 YLSLLKLDGKLILMGV 276 L + G++ L+G+ Sbjct: 252 GLQAVTPAGRVSLLGL 267 >3GFB-A nrPDB Length = 350 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 73/225 (32%), Positives = 107/225 (47%), Gaps = 29/225 (12%) Query: 33 GPEDVNIRIICCGICHTDLHQTK-NDLGMSNY--PMVPGHEVVGEVVEVGSDVSKFTVGD 89 GP +V I+++ IC TDLH + N+ S P + GHEV GEVVEVG V VGD Sbjct: 28 GPGEVLIKVLATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEDLQVGD 87 Query: 90 IVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKI 149 + V + CG C C+ + C + I G G FA +V K K Sbjct: 88 YISVETHI-VCGKCYACKHNRYHVC-------QNTKIFGVDMDGVFAHYAIVPAKNAWKN 139 Query: 150 PEGMAVEQAA---PLLCAGVTVYS-PLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGH 205 P+ M E AA PL A TV + P++ G I G G +G +G+ +AKA G Sbjct: 140 PKDMPPEYAALQEPLGNAVDTVLAGPIA-------GRSTLITGAGPLGLLGIAVAKASGA 192 Query: 206 HVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDYVID 250 + ++S ++ R + + +GA DYV+ + D + +V+D Sbjct: 193 YPVIVSEPSEFRRKLAKKVGA-DYVVNPFE------EDPVKFVMD 230 >5KIA-A nrPDB Length = 351 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 79/255 (30%), Positives = 113/255 (44%), Gaps = 21/255 (8%) Query: 31 ETGPEDVNIRIICCGICHTDLHQTKNDLGMSN---YPMVPGHEVVGEVVEVGSDVSKFTV 87 E G DV I+I IC TD+H K D PM GHE VGE+VE+G +V F++ Sbjct: 30 EVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPVPMHVGHEYVGEIVEMGQEVRGFSI 89 Query: 88 GDIV-GVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFV 146 GD V G G + CG C C C N V + G +G FA+ + Sbjct: 90 GDRVSGEGHI--TCGFCRNCRAGRRHLC------RNTVGV-GVNREGAFAEYLAIPAFNA 140 Query: 147 VKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHH 206 KIP ++ + AA G ++ LS + + L I G G +G M V IAK +G Sbjct: 141 FKIPPEISDDLAAIFDPFGNATHTALSFNLVGEDVL---ITGAGPIGVMAVAIAKHVGAR 197 Query: 207 VTVISSSNKKREEALQDLGADDYVIGSDQAKMSELAD-----SLDYVIDTVPVHHALEPY 261 VI+ N R + + +GA V S ++ +AD D ++ V A Sbjct: 198 NVVITDINDYRLDLARRMGATRAVNVSRESLRDVMADLHMTEGFDVGLEMSGVPSAFTSL 257 Query: 262 LSLLKLDGKLILMGV 276 L + GK+ L+G+ Sbjct: 258 LESMNHGGKVALLGI 272 >3WLE-A nrPDB Length = 341 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 84/313 (26%), Positives = 142/313 (45%), Gaps = 15/313 (4%) Query: 39 IRIICCGICHTDLHQTKNDLGM-SNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLV 97 +++ G+CH+DLH L NY M GHE+ G V VG DV + VGD V Sbjct: 41 LKVDAVGLCHSDLHVIYEGLDCGDNYVM--GHEIAGTVAAVGDDVINYKVGDRVACVGPN 98 Query: 98 GCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQ-KFVVKIPEGMAVE 156 GC GGC C ++ C ++ D + G GG+ + +V + + + +IP+ ++ + Sbjct: 99 GC-GGCKYCRGAIDNVCKN---AFGDWF--GLGYDGGYQQYLLVTRPRNLSRIPDNVSAD 152 Query: 157 QAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKK 216 AA A +T Y + + P ++G GG+G +++AKA G VTV+ + Sbjct: 153 VAAASTDAVLTPYHAIKMAQV-SPTSNILLIGAGGLGGNAIQVAKAFGAKVTVLDKKKEA 211 Query: 217 REEALQDLGADDYVIGSDQAKMSELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGV 276 R++A + LGAD + S S D V V + ++ G ++ +G+ Sbjct: 212 RDQA-KKLGADAVY---ETLPESISPGSFSACFDFVSVQATFDVCQKYVEPKGVIMPVGL 267 Query: 277 INNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFER 336 L F L L I GSF G+ + +++L+ E + ++ K+ + E+ Sbjct: 268 GAPNLSFNLGDLALREIRILGSFWGTTNDLDDVLKLVSEGKVKPVVRSAKLKELPEYIEK 327 Query: 337 LEKNDVRYRFVVD 349 L N R V + Sbjct: 328 LRNNAYEGRVVFN 340 >1U3W-A nrPDB Length = 374 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 83/346 (23%), Positives = 140/346 (40%), Gaps = 33/346 (9%) Query: 24 PYTYTLRETGP---EDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGS 80 P++ E P +V I+++ GIC +D H +L ++ P++ GHE G V VG Sbjct: 20 PFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNL-VTPLPVILGHEAAGIVESVGE 78 Query: 81 DVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWS---------YNDVYINGQPT 131 V+ GD V + CG C C+ YC K +G+P Sbjct: 79 GVTTVKPGDKV-IPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQDGTRRFTCSGKPI 137 Query: 132 Q-----GGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGI 186 F++ TVV + V KI +E+ + C T Y PG + Sbjct: 138 HHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTPGSTCAV 197 Query: 187 LGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAK-----MSEL 241 GLGGVG V KA G + NK + ++LGA + + D K + E+ Sbjct: 198 FGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEM 257 Query: 242 AD-SLDYVIDTV-PVHHALEPYLSLLKLDGKLILMGVINNPLQF-LTPLLMLGRKVITGS 298 D +D+ + + + + L + G +++GV + + P+L+L + G+ Sbjct: 258 TDGGVDFSFEVIGQLDTMMASLLCCHEACGTSVIVGVPPDSQNLSINPMLLLTGRTWKGA 317 Query: 299 FIGSMKETEEMLEF-----CKEKGLSSII-EVVKMDYVNTAFERLE 338 G K E + + K+ L ++I V+ + +N F+ L Sbjct: 318 IFGGFKSKESVPKLVADFMAKKFSLDALITNVLPFEKINEGFDLLR 363 >3UOG-A nrPDB Length = 363 Score = 78.6 bits (192), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 82/320 (25%), Positives = 140/320 (43%), Gaps = 25/320 (7%) Query: 31 ETGPEDVNIRIICCGICHTDLHQTKNDLGMS-NYPMVPGHEVVGEVVEVGSDVSKFTVGD 89 E G D+ +R + + + D + +G+ +P VP ++ G V VG V++F GD Sbjct: 50 EAGEHDIIVRTLAVSLNYRDKLVLETGMGLDLAFPFVPASDMSGVVEAVGKSVTRFRPGD 109 Query: 90 IVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKI 149 V G G P Y G G ++ V+ + + V Sbjct: 110 RVISTFAPGWLDGLRPGTGRTPAY-----------ETLGGAHPGVLSEYVVLPEGWFVAA 158 Query: 150 PEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTV 209 P+ + +A+ L CAG+T + L G + G R + G GGV G++IAKA G V V Sbjct: 159 PKSLDAAEASTLPCAGLTAWFALVEKGHLRAGDRVVVQGTGGVALFGLQIAKATGAEVIV 218 Query: 210 ISSSNKKREEALQDLGADDYVIGSDQAKMSELADSL------DYVIDTVPVHHALEPYLS 263 SSS +K + A LGA D+ I + E +L D++++ + L L Sbjct: 219 TSSSREKLDRAFA-LGA-DHGINRLEEDWVERVYALTGDRGADHILE-IAGGAGLGQSLK 275 Query: 264 LLKLDGKLILMGVINNPLQFLTPL--LMLGRKVITGSFIGSMKETEEMLEFCKEKGLSSI 321 + DG++ ++GV+ + P+ L+L V+ G +G + E+++ GL + Sbjct: 276 AVAPDGRISVIGVLEG-FEVSGPVGPLLLKSPVVQGISVGHRRALEDLVGAVDRLGLKPV 334 Query: 322 IEV-VKMDYVNTAFERLEKN 340 I++ K V A L++ Sbjct: 335 IDMRYKFTEVPEALAHLDRG 354 >1HSZ-A nrPDB Length = 374 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 84/348 (24%), Positives = 140/348 (40%), Gaps = 33/348 (9%) Query: 21 ILSPYTYTLRETGPE---DVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVE 77 + P++ E P +V I+++ GIC TD H +L ++ P++ GHE G V Sbjct: 17 VKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNL-VTPLPVILGHEAAGIVES 75 Query: 78 VGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWS---------YNDVYING 128 VG V+ GD V + CG C C+ YC K G Sbjct: 76 VGEGVTTVKPGDKV-IPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRG 134 Query: 129 QPTQ-----GGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLR 183 +P F++ TVV + V KI +E+ + C T Y + PG Sbjct: 135 KPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGST 194 Query: 184 GGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAK-----M 238 + GLGGVG V KA G + NK + ++LGA + + D K + Sbjct: 195 CAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVL 254 Query: 239 SELAD-SLDYVIDTV-PVHHALEPYLSLLKLDGKLILMGVINNPLQF-LTPLLMLGRKVI 295 E+ D +D+ + + + + L + G +++GV + P+L+L + Sbjct: 255 KEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTW 314 Query: 296 TGSFIGSMKETEEMLEF-----CKEKGLSSII-EVVKMDYVNTAFERL 337 G+ G K E + + K+ L ++I V+ + +N F+ L Sbjct: 315 KGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLL 362 >1HSO-A nrPDB Length = 374 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 85/350 (24%), Positives = 143/350 (40%), Gaps = 43/350 (12%) Query: 24 PYTYTLRETGP---EDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGS 80 P++ E P +V I+++ GIC TD H + ++ P++ GHE G V VG Sbjct: 20 PFSIEEVEVAPPKAHEVRIKMVAVGICGTDDHVVSGTM-VTPLPVILGHEAAGIVESVGE 78 Query: 81 DVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGG------ 134 V+ GD V + + CG C C+ YC K NDV Q G Sbjct: 79 GVTTVKPGDKV-IPLAIPQCGKCRICKNPESNYCLK-----NDVSNPQGTLQDGTSRFTC 132 Query: 135 -------------FAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPG 181 F++ TVV + V KI +E+ + C T Y + PG Sbjct: 133 RRKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPG 192 Query: 182 LRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAK---- 237 + GLGGVG + KA G + NK + ++LGA + + D K Sbjct: 193 STCAVFGLGGVGLSAIMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQE 252 Query: 238 -MSELAD-SLDYVIDTV-PVHHALEPYLSLLKLDGKLILMGVINNPLQF-LTPLLMLGRK 293 + E+ D +D+ + + + + L + G +++GV + + P+L+L + Sbjct: 253 VLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSMNPMLLLTGR 312 Query: 294 VITGSFIGSMKETEEMLEF-----CKEKGLSSII-EVVKMDYVNTAFERL 337 G+ +G K E + + K+ L ++I V+ + +N F+ L Sbjct: 313 TWKGAILGGFKSKECVPKLVADFMAKKFSLDALITHVLPFEKINEGFDLL 362 >3IP1-A nrPDB Length = 404 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 64/234 (27%), Positives = 103/234 (44%), Gaps = 31/234 (13%) Query: 34 PEDVNIRIICCGICHTDLHQTKND-------LGMSNYPMVPGHEVVGEVVEVGSDV---- 82 P ++ I++ CGIC +D+H + D G++ +P+ GHE G VVE G + Sbjct: 55 PTEIIIKVKACGICGSDVHMAQTDEEGYILYPGLTGFPVTLGHEFSGVVVEAGPEAINRR 114 Query: 83 --SKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATV 140 +F +G+ V ++ CG C PC +C + N++ N G FA+ Sbjct: 115 TNKRFEIGEPVCAEEML-WCGHCRPCAEGFPNHCE----NLNELGFN---VDGAFAEYVK 166 Query: 141 VHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFG---LKQPGLRGG----ILGLGGVG 193 V K+ + E V + L AG V + ++ G+R G ILG G +G Sbjct: 167 VDAKYAWSLRELEGVYEGDRLFLAGSLVEPTSVAYNAVIVRGGGIRPGDNVVILGGGPIG 226 Query: 194 HMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDY 247 V I K G ++S ++ R ++LGAD + D K + + LDY Sbjct: 227 LAAVAILKHAGASKVILSEPSEVRRNLAKELGADHVI---DPTKENFVEAVLDY 277 >1CDO-A nrPDB Length = 374 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 74/294 (25%), Positives = 125/294 (42%), Gaps = 28/294 (9%) Query: 35 EDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVG 94 ++ I+II G+CHTDL+ +P+V GHE G V VG V++F G+ V + Sbjct: 34 NEIRIKIIATGVCHTDLYHLFEGKHKDGFPVVLGHEGAGIVESVGPGVTEFQPGEKV-IP 92 Query: 95 CLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQ--------------GGFAKATV 140 + CG C C+ C K + + ++ + T+ F++ TV Sbjct: 93 LFISQCGECRFCQSPKTNQCVKGWANESPDVMSPKETRFTCKGRKVLQFLGTSTFSQYTV 152 Query: 141 VHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIA 200 V+Q V KI ++ L C T + + +PG + GLG VG V Sbjct: 153 VNQIAVAKIDPSAPLDTVCLLGCGVSTGFGAAVNTAKVEPGSTCAVFGLGAVGLAAVMGC 212 Query: 201 KAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAK-----MSELAD-----SLDYVID 250 + G + N + E + GA D+V +D ++ +S++ + SL+ V + Sbjct: 213 HSAGAKRIIAVDLNPDKFEKAKVFGATDFVNPNDHSEPISQVLSKMTNGGVDFSLECVGN 272 Query: 251 TVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMK 304 + +ALE S LK G +L+G + P+ ++ + GS G K Sbjct: 273 VGVMRNALE---SCLKGWGVSVLVGWTDLHDVATRPIQLIAGRTWKGSMFGGFK 323 >5YLN-A nrPDB Length = 356 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 85/331 (25%), Positives = 136/331 (41%), Gaps = 22/331 (6%) Query: 34 PEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGV 93 P D +RI+ IC TDLH K D+ + GHE +G V EVG VS F GD V + Sbjct: 29 PTDAIVRIVKTTICGTDLHIIKGDVPTCQSGTILGHEGIGIVEEVGEGVSNFKKGDKVLI 88 Query: 94 GCLVGCCGGCSPCERDLEQYCPKK-IWSYNDVY--INGQPTQGGFAKATVVHQKFVVKIP 150 C V CG C C++ + +C + W + + + + + A T+ H P Sbjct: 89 SC-VCACGKCYYCKKGIYAHCEDEGGWIFGHLIDGMQAEYLRVPHADNTLYHT------P 141 Query: 151 EGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVI 210 E ++ E L T Y G +PG I+G G VG + A+ ++ Sbjct: 142 EDLSDEALVMLSDILPTGYEIGVLKGKVEPGCSVAIIGSGPVGLAALLTAQFYSPAKLIM 201 Query: 211 SSSNKKREEALQDLGADDYVIGSDQAK-MSELAD-----SLDYVIDTVPVHHALEPYLSL 264 + R E GA V SD K + E+ D +D I+ V + + + Sbjct: 202 VDLDDNRLETALSFGATHKVNSSDPEKAIKEIYDLTDGRGVDVAIEAVGIPATFDFCQKI 261 Query: 265 LKLDGKLILMGVINNPLQF-LTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSS--- 320 + +DG + GV P++F L L + V TG + S T ++L+ + + Sbjct: 262 IGVDGTVANCGVHGKPVEFDLDKLWIRNINVTTG--LVSTNTTPQLLKALESHKIEPEKL 319 Query: 321 IIEVVKMDYVNTAFERLEKNDVRYRFVVDVE 351 + K+ + A+E K + V +E Sbjct: 320 VTHYFKLSEIEKAYEVFSKAADHHAIKVIIE 350 >4EJ6-A nrPDB Length = 370 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 78/297 (26%), Positives = 128/297 (43%), Gaps = 34/297 (11%) Query: 20 GILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVG 79 G +S + E GP+D+ +++ CGIC TD H + S P+ GHE G VVE G Sbjct: 33 GNISVRNVGIPEPGPDDLLVKVEACGICGTDRHLLHGEF-PSTPPVTLGHEFCGIVVEAG 91 Query: 80 SDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKAT 139 S V G + G CG C C+ C ++ G GGFA+ Sbjct: 92 SAVRDIAPGARI-TGDPNISCGRCPQCQAGRVNLC-------RNLRAIGIHRDGGFAEYV 143 Query: 140 VVHQKFVVKIPEGMAVEQAA---PLLCAGVTVYSPLSHFGLKQPGLRGG----ILGLGGV 192 +V +K +IP + A PL C G+ G++ G ILG G + Sbjct: 144 LVPRKQAFEIPLTLDPVHGAFCEPLACC---------LHGVDLSGIKAGSTVAILGGGVI 194 Query: 193 GHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELA-------DSL 245 G + V++A+ G ++S+ + +++GA V S + +A + Sbjct: 195 GLLTVQLARLAGATTVILSTRQATKRRLAEEVGATATVDPSAGDVVEAIAGPVGLVPGGV 254 Query: 246 DYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQF-LTPLLMLGRKV-ITGSFI 300 D VI+ V ++ L K G ++++GV+ + + P +L R++ + GSFI Sbjct: 255 DVVIECAGVAETVKQSTRLAKAGGTVVILGVLPQGEKVEIEPFDILFRELRVLGSFI 311 >1D1T-A nrPDB Length = 373 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 76/317 (23%), Positives = 134/317 (42%), Gaps = 28/317 (8%) Query: 24 PYTYTLRETGP---EDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGS 80 P++ E P ++V I+I+ GIC TD H K + +S +P++ GHE G V +G Sbjct: 20 PFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTM-VSKFPVIVGHEATGIVESIGE 78 Query: 81 DVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYING--------QPTQ 132 V+ GD V + + C C+ C C + + V +G +P Sbjct: 79 GVTTVKPGDKV-IPLFLPQCRECNACRNPDGNLCIRSDITGRGVLADGTTRFTCKGKPVH 137 Query: 133 -----GGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGIL 187 F + TVV + V KI + E+ + C T Y G +PG + Sbjct: 138 HFLNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVF 197 Query: 188 GLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAK-----MSELA 242 GLGGVG + K+ G + NK + E +GA + + D K +SE+ Sbjct: 198 GLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECISPKDSTKPISEVLSEMT 257 Query: 243 -DSLDYVIDTVPVHHALEPYLSLLKLD-GKLILMGVINNPLQFLT--PLLMLGRKVITGS 298 +++ Y + + + L+ ++ G +++GV + + LT P+L+ + G Sbjct: 258 GNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSA-KMLTYDPMLLFTGRTWKGC 316 Query: 299 FIGSMKETEEMLEFCKE 315 G +K +++ + E Sbjct: 317 VFGGLKSRDDVPKLVTE 333 >4RQU-A nrPDB Length = 375 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 82/335 (24%), Positives = 138/335 (41%), Gaps = 30/335 (8%) Query: 36 DVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGC 95 +V I+I+ +CHTD++ + +P + GHE G V VG V+ GD V + Sbjct: 32 EVRIKILFTSLCHTDVYFWEAKGQTPLFPRIFGHEAGGIVESVGEGVTDLQPGDHV-LPI 90 Query: 96 LVGCCGGCSPCERDLEQYC------PKKIWSYND----VYINGQPT-----QGGFAKATV 140 G CG C C + C ++ +D ING+P F++ TV Sbjct: 91 FTGECGECRHCHSEESNMCDLLRINTERGGMIHDGESRFSINGKPIYHFLGTSTFSEYTV 150 Query: 141 VHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIA 200 VH V KI +++ + C T + + G I GLG VG + A Sbjct: 151 VHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFGLGAVGLGAAEGA 210 Query: 201 KAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAK-----MSELAD-SLDYVID-TVP 253 + G + N KR + ++ G + V D K ++E+ D +D ++ T Sbjct: 211 RIAGASRIIGVDFNSKRFDQAKEFGVTECVNPKDHDKPIQQVIAEMTDGGVDRSVECTGS 270 Query: 254 VHHALEPYLSLLKLDGKLILMGVINNPLQFLT-PLLMLGRKVITGSFIGSMKETEEM--- 309 V ++ + + G +L+GV + F T P+ L + + G+F G+ K ++ Sbjct: 271 VQAMIQAFECVHDGWGVAVLVGVPSKDDAFKTHPMNFLNERTLKGTFFGNYKPKTDIPGV 330 Query: 310 LEFCKEKGL---SSIIEVVKMDYVNTAFERLEKND 341 +E K L I V +N AF+ + K + Sbjct: 331 VEKYMNKELELEKFITHTVPFSEINKAFDYMLKGE 365 >4ILK-A nrPDB Length = 359 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 68/256 (26%), Positives = 114/256 (44%), Gaps = 20/256 (7%) Query: 36 DVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGC 95 +V +++ GIC +D H + + YP V GHE G + VG V VG+ V V Sbjct: 46 EVRVKVKLAGICGSDSHIYRGHNPFAKYPRVIGHEFFGVIDAVGEGVESARVGERVAVDP 105 Query: 96 LVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAV 155 +V CG C PC C + + G GGF++ VV K KIPE +A Sbjct: 106 VVS-CGHCYPCSIGKPNVC-------TTLAVLGVHADGGFSEYAVVPAKNAWKIPEAVAD 157 Query: 156 EQAAPLLCAGVTVYSPLSHFGLKQPGLRGGIL--GLGGVGHMGVKIAKAMGHHVTVISSS 213 + A ++ T+ + ++ G QP +L G G +G V++ K + + VI + Sbjct: 158 QYA--VMIEPFTIAANVTGHG--QPTENDTVLVYGAGPIGLTIVQVLKGVYNVKNVIVAD 213 Query: 214 N-KKREEALQDLGADDYVIGSDQAKM----SELADSLDYVIDTVPVHHALEPYLSLLKLD 268 +R E ++ GA D+ I + Q + +E +ID L+ ++L Sbjct: 214 RIDERLEKAKESGA-DWAINNSQTPLGESFAEKGIKPTLIIDAACHPSILKEAVTLASPA 272 Query: 269 GKLILMGVINNPLQFL 284 +++LMG + P + + Sbjct: 273 ARIVLMGFSSEPSEVI 288 >4CPD-A nrPDB Length = 347 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 78/273 (28%), Positives = 120/273 (43%), Gaps = 30/273 (10%) Query: 30 RETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPG----HEVVGEVVEVGSDVSKF 85 R P D +R+ GIC +DLH L P++PG HE VG+V VG + Sbjct: 21 RLQHPLDALVRVHLAGICGSDLH-----LYHGKIPVLPGSVLGHEFVGQVEAVGEGIQDL 75 Query: 86 TVGDIVGVGCLVGCCGGCSPCERDLEQYCPKK-IWSYNDVYINGQPTQGGFAKATVVHQK 144 GD V VG CG C C R C + ++ Y ++ N Q Q + + Sbjct: 76 QPGDWV-VGPFHIACGTCPYCRRHQYNLCERGGVYGYGPMFGNLQGAQAEILRVPFSNVN 134 Query: 145 FVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGG----ILGLGGVGHMGVKIA 200 K+P ++ E+A + AG + + ++ GL Q LR G ++G G VG M +++A Sbjct: 135 LR-KLPPNLSPERA---IFAGDILST--AYGGLIQGQLRPGDSVAVIGAGPVGLMAIEVA 188 Query: 201 KAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAK-----MSELADS-LDYVIDTVPV 254 + +G + +R E LGA I ++Q SE D D V++ V Sbjct: 189 QVLGASKILAIDRIPERLERAASLGA--IPINAEQENPVRRVRSETNDEGPDLVLEAVGG 246 Query: 255 HHALEPYLSLLKLDGKLILMGVINNPLQFLTPL 287 L L +++ G++ +GV N P F PL Sbjct: 247 AATLSLALEMVRPGGRVSAVGVDNAP-SFPFPL 278 >1EE2-A nrPDB Length = 373 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 79/345 (22%), Positives = 141/345 (40%), Gaps = 32/345 (9%) Query: 24 PYTYTLRETGP---EDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGS 80 P++ E P +V I+++ GIC +D H L ++ P++ GHE G V +G Sbjct: 20 PFSIEEVEVAPPKAHEVRIKMVAAGICRSDDHVVSGTL-VAPLPVIAGHEAAGIVESIGE 78 Query: 81 DVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIW--------SYNDVYINGQPTQ 132 V+ GD V + + CG CS C+ C K + + G+P Sbjct: 79 GVTTVRPGDKV-IPLFIPQCGKCSVCKHPEGNLCLKNLSMPRGTMQDGTSRFTCRGKPIH 137 Query: 133 -----GGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGIL 187 F++ TVV + V KI +E+ + C T Y G + Sbjct: 138 HFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLVGCGFSTGYGSAVKVAKVTQGSTCAVF 197 Query: 188 GLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAK-----MSELA 242 GLGGVG + KA G + NK + +++GA + V D K ++E++ Sbjct: 198 GLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDYKKPIQEVLTEMS 257 Query: 243 D-SLDYVIDTVPVHHALEPYLSLLK-LDGKLILMGVINNPLQF-LTPLLMLGRKVITGSF 299 + +D+ + + + LS + G +++GV + + P+L+L + G+ Sbjct: 258 NGGVDFSFEVIGRLDTMVAALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAI 317 Query: 300 IGSMKETEEMLEF-----CKEKGLSSII-EVVKMDYVNTAFERLE 338 G K + + + K+ L +I V+ + +N F+ L Sbjct: 318 FGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLR 362 >4JJI-A nrPDB Length = 378 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 81/334 (24%), Positives = 137/334 (41%), Gaps = 32/334 (9%) Query: 36 DVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGC 95 +V I+I+ +CHTD + +P + GHE G V VG V++ GD V + C Sbjct: 35 EVRIKILYTALCHTDAYTWSGKDPEGLFPCILGHEAAGIVESVGEGVTEVQAGDHV-IPC 93 Query: 96 LVGCCGGCSPCERDLEQYCPKKIWS------YND----VYINGQPT-----QGGFAKATV 140 C C C+ C K + ND +NG+P F++ TV Sbjct: 94 YQAECRECKFCKSGKTNLCGKVRSATGVGIMMNDRKSRFSVNGKPIYHFMGTSTFSQYTV 153 Query: 141 VHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIA 200 VH V KI +++ L C T + + +PG I GLG VG + A Sbjct: 154 VHDVSVAKIDPTAPLDKVCLLGCGVPTGLGAVWNTAKVEPGSNVAIFGLGTVGLAVAEGA 213 Query: 201 KAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAK-----MSELAD-SLDYVIDTVPV 254 K G + + K+ E + G +++V D K + +L D +DY + + Sbjct: 214 KTAGASRIIGIDIDSKKYETAKKFGVNEFVNPKDHDKPIQEVIVDLTDGGVDYSFECIGN 273 Query: 255 HHALEPYLSLL-KLDGKLILMGVINNPLQFLT-PLLMLGRKVITGSFIGSMKETEEMLEF 312 + L K G +++GV + + T P ++ +V G+ G K + + + Sbjct: 274 VSVMRAALECCHKGWGTSVIVGVAASGQEISTRPFQLVTGRVWKGTAFGGFK-SRTQVPW 332 Query: 313 CKEKGLSSIIEV-------VKMDYVNTAFERLEK 339 EK ++ I+V + + +N AF+ L + Sbjct: 333 LVEKYMNKEIKVDEYITHNLTLGEINKAFDLLHE 366 >4UEJ-A nrPDB Length = 346 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 67/257 (26%), Positives = 111/257 (43%), Gaps = 18/257 (7%) Query: 35 EDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVG 94 ++V ++I G+C +DL + + G YP+ GHE G + VGS V GD V Sbjct: 26 DEVRVKIASSGLCGSDLPRIFKN-GAHYYPITLGHEFSGYIDAVGSGVDDLHPGDAVACV 84 Query: 95 CLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMA 154 L+ C C C + C K Y+ + G GGFA+ VV +K V +P M Sbjct: 85 PLLPCF-TCPECLKGFYSQCAK----YDFI---GSRRDGGFAEYIVVKRKNVFALPTDMP 136 Query: 155 VEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMG-HHVTVISSS 213 +E A +TV H I+G G +G + ++ A A+G VT I S Sbjct: 137 IEDGA--FIEPITVGLHAFHLAQGCENKNVIIIGAGTIGLLAIQCAVALGAKSVTAIDIS 194 Query: 214 NKKRE-----EALQDLGADDYVIGSDQAKMSELADSLDYVIDTVPVHHALEPYLSLLKLD 268 ++K A+Q + + Q+ + EL + +++T V +E + + Sbjct: 195 SEKLALAKSFGAMQTFNSSEMSAPQMQSVLRELRFN-QLILETAGVPQTVELAVEIAGPH 253 Query: 269 GKLILMGVINNPLQFLT 285 +L L+G ++ L + Sbjct: 254 AQLALVGTLHQDLHLTS 270 >4OH1-A nrPDB Length = 351 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 73/260 (28%), Positives = 110/260 (42%), Gaps = 30/260 (11%) Query: 31 ETGPEDVNIRIICCGICHTDLHQTKNDLG------MSNYPMVPGHEVVGEVVEVGSDVSK 84 E E++ I+++ IC +D H +LG S PM GHE+ G + +VGS K Sbjct: 30 EPKDEEIRIKVVYASICGSDTHILTGNLGEMESTTRSMLPMSFGHELSGVIDKVGSTAEK 89 Query: 85 --FTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVH 142 F VG V V CG C C C + N GF++ V H Sbjct: 90 MGFKVGQKV-VANYAKYCGCCENCREGKVNLCSNMGYRMN-----------GFSEYAVYH 137 Query: 143 QKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKA 202 + IP+ ++ A L +TV + G I+G GG+G M V++A+ Sbjct: 138 MSQIFPIPDDADLKDYA--LVEPLTVALSSAEQAKISYGKSVAIMGAGGLGMMLVQLARL 195 Query: 203 MGHH-VTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSL-----DYVIDTVPVHH 256 G +TV +K E AL++ GA DY + S + ++E A L D V++ Sbjct: 196 AGASTITVFDIVPEKLELALEN-GA-DYALNSAEEGVAERAIELAGGRYDCVLEGTGATA 253 Query: 257 ALEPYLSLLKLDGKLILMGV 276 A + L LL DG + + Sbjct: 254 AAKLGLQLLARDGDAVYFAM 273 >5VM2-A nrPDB Length = 347 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 73/264 (27%), Positives = 117/264 (44%), Gaps = 41/264 (15%) Query: 35 EDVNIRIICCGICHTDLHQTKNDLGMSNYPMVP----------GHEVVGEVVEVGSDVSK 84 ++V I++ GIC +D+H G + P +P GHE G VV VGS V K Sbjct: 27 DEVLIKVEYVGICGSDVH------GFESGPFIPPKDPNQEIGLGHECAGTVVAVGSRVRK 80 Query: 85 FTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDV-YINGQPTQGGFAKATVVH- 142 F GD V + V CG C C CP DV ++ QP G + H Sbjct: 81 FKPGDRVNIEPGVP-CGHCRYCLEGKYNICP-------DVDFMATQPNYRGALTHYLCHP 132 Query: 143 QKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKA 202 + F K+P+ M + + A V +++ + +PG + ILG G +G M ++ K Sbjct: 133 ESFTYKLPDNMDTMEGTLVEPAAVGMHAAM--LADVKPGKKIIILGAGCIGLMTLQACKC 190 Query: 203 MGHHVTVISSSNKKREEALQDLGADDYVIGSDQ---AKMSELADSL--DYVIDT----VP 253 +G + +KR + LGA + G+ + A+ + + + D V +T V Sbjct: 191 LGATEIAVVDVLEKRLAMAEQLGATVVINGAKEDTIARCQQFTEDMGADIVFETAGSAVT 250 Query: 254 VHHALEPYLSLLKLDGKLILMGVI 277 V A PYL + GK++++G + Sbjct: 251 VKQA--PYLVM--RGGKIMIVGTV 270 >1F8F-A nrPDB Length = 371 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 79/342 (23%), Positives = 143/342 (41%), Gaps = 33/342 (9%) Query: 29 LRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVG 88 +R+ ++V ++++ G+CHTDL + P V GHE G + +G +V++ VG Sbjct: 26 IRQPQGDEVLVKVVATGMCHTDLIVRDQKYPVP-LPAVLGHEGSGIIEAIGPNVTELQVG 84 Query: 89 DIVGVGCLVGCCGGCSPCERDLEQYCPK---------------KIWSYNDVYINGQ-PTQ 132 D V + G CG C+ C YC + + +++ +N Q Sbjct: 85 DHVVLS--YGYCGKCTQCNTGNPAYCSEFFGRNFSGADSEGNHALCTHDQGVVNDHFFAQ 142 Query: 133 GGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLK-QPGLRGGILGLGG 191 FA + + VK+ + + +E PL C G+ + LK P G G Sbjct: 143 SSFATYALSRENNTVKVTKDVPIELLGPLGC-GIQTGAGACINALKVTPASSFVTWGAGA 201 Query: 192 VGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQ---AKMSELAD-SLDY 247 VG + AK G + + + R E + LGA + Q A + E+ D +++ Sbjct: 202 VGLSALLAAKVCGASIIIAVDIVESRLELAKQLGATHVINSKTQDPVAAIKEITDGGVNF 261 Query: 248 VIDTVPVHHALEPYLSLLKLDGKLILMGV--INNPLQFLTPLLMLGRKVITGSFIGSMKE 305 +++ L+ + L + GK+ ++G + QF L+LG K I G GS Sbjct: 262 ALESTGSPEILKQGVDALGILGKIAVVGAPQLGTTAQFDVNDLLLGGKTILGVVEGSGSP 321 Query: 306 TEEMLEFCK--EKGLSSIIEVVKMDYVNTAFERLEKNDVRYR 345 + + E + ++G ++VK AF+ + + + R Sbjct: 322 KKFIPELVRLYQQGKFPFDQLVKF----YAFDEINQAAIDSR 359 >3QE3-A nrPDB Length = 355 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 62/246 (25%), Positives = 111/246 (45%), Gaps = 31/246 (12%) Query: 20 GILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKN-DLG--MSNYPMVPGHEVVGEVV 76 G L Y + E GP +V +++ GIC +D+H ++ +G + PMV GHE G VV Sbjct: 16 GDLRLENYPIPEPGPNEVLLKMHSVGICGSDVHYWQHGRIGDFVVKKPMVLGHEASGTVV 75 Query: 77 EVGSDVSKFTVGDIVGVGCLVGCCGGCSP-CERDLEQYCPKKIWSYN----DVYINGQPT 131 +VGS V GD V + P R +++C KI YN + P Sbjct: 76 KVGSLVRHLQPGDRVAI----------QPGAPRQTDEFC--KIGRYNLSPTIFFCATPPD 123 Query: 132 QGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGG----IL 187 G + + F K+P+ + E+ A + V +++ ++ G+ G + Sbjct: 124 DGNLCRFYKHNANFCYKLPDNVTFEEGALIEPLSVGIHA------CRRAGVTLGNKVLVC 177 Query: 188 GLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDY 247 G G +G + + AKAMG V++ + R +++GA D+++ E+A ++ Sbjct: 178 GAGPIGLVNLLAAKAMGAAQVVVTDLSASRLSKAKEVGA-DFILEISNESPEEIAKKVEG 236 Query: 248 VIDTVP 253 ++ + P Sbjct: 237 LLGSKP 242 >4DLA-A nrPDB Length = 396 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 82/345 (23%), Positives = 141/345 (40%), Gaps = 33/345 (9%) Query: 36 DVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGC 95 +V ++++ +CHTD + +P V GHE G V VG V++ GD V + C Sbjct: 53 EVRVKVLYTALCHTDAYTWSGKDPEGLFPCVLGHEAAGIVESVGEGVTEVQPGDHV-IPC 111 Query: 96 LVGCCGGCSPCERDLEQYCPKKIWS------YND----VYINGQPT-----QGGFAKATV 140 C C C+ C K + ND ING+P F++ TV Sbjct: 112 YQAECRECKFCKSGKTNLCGKVRAATGVGVMMNDRKSRFSINGKPIYHFMGTSTFSQYTV 171 Query: 141 VHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIA 200 VH V KI +E+ L C T + + +PG + GLG VG + A Sbjct: 172 VHDVSVAKIDPVAPLEKVCLLGCGVPTGLGAVWNTAKVEPGSIVAVFGLGTVGLAVAEGA 231 Query: 201 KAMGHHVTVISSSNKKREEALQDLGADDYVIGSD-----QAKMSELAD-SLDYVIDTVPV 254 KA G + + K+ + ++ G +++ + Q + +L D +DY + + Sbjct: 232 KAAGASRIIGIDIDSKKFDRAKNFGVTEFINPKEHEQPIQQVIVDLTDGGVDYSFECIGN 291 Query: 255 HHALEPYLSLL-KLDGKLILMGVINNPLQFLT-PLLMLGRKVITGSFIGSMKETEEMLEF 312 + L K G +++GV + + T P ++ +V G+ G K ++ Sbjct: 292 VSVMRSALECCHKGWGTSVIVGVAASGQEISTRPFQLVTGRVWKGTAFGGFKSRSQVPSL 351 Query: 313 CKEKGLSSIIEV-------VKMDYVNTAFERLEKNDVRYRFVVDV 350 +K L I+V + + +N AF+ + D R V+D+ Sbjct: 352 V-DKYLKKEIKVDEYITHNMTLADINKAFDLMHDGDC-LRVVLDM 394 >2DQ4-A nrPDB Length = 343 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 58/190 (30%), Positives = 80/190 (42%), Gaps = 13/190 (6%) Query: 31 ETGPEDVNIRIICCGICHTDLHQTKNDL---GMSNYPMVPGHEVVGEVVEVGSDVSKFTV 87 E GP ++ +R+ IC TDLH K D G P+V GHE G V VG V + V Sbjct: 22 EPGPGEILVRVEAASICGTDLHIWKWDAWARGRIRPPLVTGHEFSGVVEAVGPGVRRPQV 81 Query: 88 GDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVV 147 GD V + + C C C C + I G GGFA+ VV + Sbjct: 82 GDHVSLESHI-VCHACPACRTGNYHVC-------LNTQILGVDRDGGFAEYVVVPAENAW 133 Query: 148 KIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHV 207 P+ + E AA L G V++ + G+ G I G G +G M + +A G Sbjct: 134 VNPKDLPFEVAAILEPFGNAVHTVYAGSGVS--GKSVLITGAGPIGLMAAMVVRASGAGP 191 Query: 208 TVISSSNKKR 217 ++S N R Sbjct: 192 ILVSDPNPYR 201 >1E3J-A nrPDB Length = 352 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 70/264 (26%), Positives = 121/264 (45%), Gaps = 34/264 (12%) Query: 31 ETGPEDVNIRIICCGICHTDLHQTKN----DLGMSNYPMVPGHEVVGEVVEVGSDVSKFT 86 E ++V +++ GIC +D+H ++ D + + PMV GHE G VV+VG +V Sbjct: 25 EPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKD-PMVIGHEASGTVVKVGKNVKHLK 83 Query: 87 VGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFV 146 GD V V V C C C+ CP + + P G A+ V F Sbjct: 84 KGDRVAVEPGVP-CRRCQFCKEGKYNLCP------DLTFCATPPDDGNLARYYVHAADFC 136 Query: 147 VKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGG----ILGLGGVGHMGVKIAKA 202 K+P+ +++E+ A L V V++ ++ G++ G ++G G +G + V AKA Sbjct: 137 HKLPDNVSLEEGALLEPLSVGVHA------CRRAGVQLGTTVLVIGAGPIGLVSVLAAKA 190 Query: 203 MGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSE----------LADSLDYVIDTV 252 G V V ++ + +R E ++ GAD ++ D AK E + D + ID Sbjct: 191 YGAFV-VCTARSPRRLEVAKNCGADVTLV-VDPAKEEESSIIERIRSAIGDLPNVTIDCS 248 Query: 253 PVHHALEPYLSLLKLDGKLILMGV 276 + +++ + G L+L+G+ Sbjct: 249 GNEKCITIGINITRTGGTLMLVGM 272 >1P0F-A nrPDB Length = 373 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 89/352 (25%), Positives = 142/352 (40%), Gaps = 32/352 (9%) Query: 15 ARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGE 74 A +P LS T T+ +V I+I+ GIC +D K ++ S +P++ GHE VG Sbjct: 15 AWEPHKPLSLETITVAPPKAHEVRIKILASGICGSDSSVLK-EIIPSKFPVILGHEAVGV 73 Query: 75 VVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWS---------YNDVY 125 V +G+ V+ GD V + V CG C C+ +C K + Sbjct: 74 VESIGAGVTCVKPGDKV-IPLFVPQCGSCRACKSSNSNFCEKNDMGAKTGLMADMTSRFT 132 Query: 126 INGQPT-----QGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQP 180 G+P F + TVV V KI +E + C T Y + P Sbjct: 133 CRGKPIYNLMGTSTFTEYTVVADIAVAKIDPKAPLESCL-IGCGFATGYGAAVNTAKVTP 191 Query: 181 GLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAK--- 237 G + GLGGVG + KA G + ++K + +LGA + + D K Sbjct: 192 GSTCAVFGLGGVGFSAIVGCKAAGASRIIGVGTHKDKFPKAIELGATECLNPKDYDKPIY 251 Query: 238 ---MSELADSLDYVIDTV-PVHHALEPYLSLLKLDGKLILMGVI--NNPLQFLTPLLMLG 291 + +DY ++ + + S G +++G+ N L LL+ G Sbjct: 252 EVICEKTNGGVDYAVECAGRIETMMNALQSTYCGSGVTVVLGLASPNERLPLDPLLLLTG 311 Query: 292 RKVITGSFIGSMK--ETEEML-EFCKEKGLSSIIEVVK--MDYVNTAFERLE 338 R + GS G K E ++ ++ K+K + + K +D +N AFE L Sbjct: 312 RS-LKGSVFGGFKGEEVSRLVDDYMKKKINVNFLVSTKLTLDQINKAFELLS 362 >3FBG-A nrPDB Length = 346 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 65/272 (23%), Positives = 110/272 (40%), Gaps = 49/272 (18%) Query: 20 GILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVG 79 + + + E ++ ++I + D Q D+ S P V G + +G V VG Sbjct: 18 NLFKTFNLDIPEPKVHEILVKIQSISVNPVDTKQRLMDV--SKAPRVLGFDAIGVVESVG 75 Query: 80 SDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGF-AKA 138 ++V+ F GDIV Y +G P Q G A+ Sbjct: 76 NEVTMFNQGDIV---------------------------------YYSGSPDQNGSNAEY 102 Query: 139 TVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSH-FGLKQPGLRGG------ILGLGG 191 +++++ V K P+ ++ EQA L G+T Y L FG+ + I G GG Sbjct: 103 QLINERLVAKAPKNISAEQAVSLPLTGITAYETLFDVFGISRNRNENEGKTLLIINGAGG 162 Query: 192 VGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADS----LDY 247 VG + +IAKA G V +S N+ E + +GA D V+ ++ +++ +DY Sbjct: 163 VGSIATQIAKAYGLRVITTASRNETIEWT-KKMGA-DIVLNHKESLLNQFKTQGIELVDY 220 Query: 248 VIDTVPVHHALEPYLSLLKLDGKLILMGVINN 279 V T + + L+K G + + N Sbjct: 221 VFCTFNTDMYYDDMIQLVKPRGHIATIVAFEN 252 >1PL8-A nrPDB Length = 356 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 95/211 (45%), Gaps = 24/211 (11%) Query: 26 TYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNY----PMVPGHEVVGEVVEVGSD 81 Y + E GP +V +R+ GIC +D+H + + N+ PMV GHE G V +VGS Sbjct: 23 NYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGR-IGNFIVKKPMVLGHEASGTVEKVGSS 81 Query: 82 VSKFTVGDIVGVGCLVGCCGGCSP-CERDLEQYCPKKIWSYN----DVYINGQPTQGGFA 136 V GD V + P R+ +++C K+ YN + P G Sbjct: 82 VKHLKPGDRVAI----------EPGAPRENDEFC--KMGRYNLSPSIFFCATPPDDGNLC 129 Query: 137 KATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMG 196 + + F K+P+ + E+ A + V +++ G G + + G G +G + Sbjct: 130 RFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHA--CRRGGVTLGHKVLVCGAGPIGMVT 187 Query: 197 VKIAKAMGHHVTVISSSNKKREEALQDLGAD 227 + +AKAMG V++ + R +++GAD Sbjct: 188 LLVAKAMGAAQVVVTDLSATRLSKAKEIGAD 218 >3TQH-A nrPDB Length = 321 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 56/207 (27%), Positives = 96/207 (46%), Gaps = 39/207 (18%) Query: 52 HQTKNDLGM------SNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSP 105 ++T+N G +N P G++ GEV+E+GSDV+ +GD V +G G Sbjct: 50 YKTRNGSGFVAKKLKNNLPSGLGYDFSGEVIELGSDVNNVNIGDKV-----MGIAG---- 100 Query: 106 CERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAG 165 P Y + Y+ P +++ E ++ QAA L AG Sbjct: 101 --------FPDHPCCYAE-YVCASPDT-------------IIQKLEKLSFLQAASLPTAG 138 Query: 166 VTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLG 225 +T L+ +KQ + G GGVGH+ +++AK G TVI++++K+ L+ LG Sbjct: 139 LTALQALNQAEVKQGDVVLIHAGAGGVGHLAIQLAKQKG--TTVITTASKRNHAFLKALG 196 Query: 226 ADDYVIGSDQAKMSELADSLDYVIDTV 252 A+ + ++ + ++ +D VID V Sbjct: 197 AEQCINYHEEDFLLAISTPVDAVIDLV 223 >3COS-A nrPDB Length = 381 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 80/337 (23%), Positives = 130/337 (38%), Gaps = 35/337 (10%) Query: 36 DVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGC 95 +V I+II +CHTD + +P++ GHE G V +G V+ GD V + Sbjct: 37 EVRIQIIATSLCHTDATVIDSKFEGLAFPVIVGHEAAGIVESIGPGVTNVKPGDKV-IPL 95 Query: 96 LVGCCGGCSPCERDLEQYCPK--KIWS-----------YNDVYINGQPT-----QGGFAK 137 C C C L C K + S + G+P F++ Sbjct: 96 YAPLCRKCKFCLSPLTNLCGKISNLKSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQ 155 Query: 138 ATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGV 197 TVV + KI + +E+ L C T Y + PG + GLGGVG V Sbjct: 156 YTVVSDINLAKIDDDANLERVCLLGCGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAV 215 Query: 198 KIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSD-----QAKMSELAD-SLDYVIDT 251 KA G + N ++ + LGA D + D Q + EL +D+ +D Sbjct: 216 MGCKAAGASRIIGIDINSEKFVKAKALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDC 275 Query: 252 VPVHHALEPYLSLLKLD-GKLILMGVI--NNPLQFLTPLLMLGRKVITGSFIGSMKETEE 308 ++ L G +GV + L L++GR I G+F G K + Sbjct: 276 AGGSETMKAALDCTTAGWGSCTFIGVAAGSKGLTVFPEELIIGR-TINGTFFGGWKSVDS 334 Query: 309 MLEFC-----KEKGLSSII-EVVKMDYVNTAFERLEK 339 + + K+ L +++ + D ++ AF+ + + Sbjct: 335 IPKLVTDYKNKKFNLDALVTHTLPFDKISEAFDLMNQ 371 >1MC5-A nrPDB Length = 374 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 85/365 (23%), Positives = 136/365 (37%), Gaps = 46/365 (12%) Query: 8 RKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVP 67 + W A P LS + +V I+II +CHTD + +P++ Sbjct: 9 KAAVAWEAGKP---LSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGCFPVIL 65 Query: 68 GHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPK-KIWSYNDVYI 126 GHE G V VG V+K GD V + + CG C C C K ++ + Sbjct: 66 GHEGAGIVESVGEGVTKLKAGDTV-IPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMP 124 Query: 127 NGQPT-------------QGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLS 173 +G F++ TVV V KI +++ L C T Y Sbjct: 125 DGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAV 184 Query: 174 HFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGS 233 + +PG + GLGGVG + K G + NK + ++ GA + + Sbjct: 185 NTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATECINPQ 244 Query: 234 DQAK-----MSELAD-SLDYVIDTVP----VHHALEP----YLSLLKLDGKLILMGVINN 279 D +K + E+ D +DY + + + ALE + + + + Sbjct: 245 DFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATR 304 Query: 280 PLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSSIIEV-------VKMDYVNT 332 P Q +T GR G+ G K E + + E +S I+V + D +N Sbjct: 305 PFQLVT-----GR-TWKGTAFGGWKSVESVPKLVSEY-MSKKIKVDEFVTHNLSFDEINK 357 Query: 333 AFERL 337 AFE + Sbjct: 358 AFELM 362 >5A3V-A nrPDB Length = 329 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 76/275 (27%), Positives = 114/275 (41%), Gaps = 52/275 (18%) Query: 63 YPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYN 122 +P +P +V GEVVEVGS V F GD V V L GG Sbjct: 65 FPCIPATDVAGEVVEVGSGVKNFKAGDKV-VAVLSHLGGG-------------------- 103 Query: 123 DVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSH---FGLKQ 179 G A+ V +K VK P+ + +AA L AG+T L++ L Sbjct: 104 -----------GLAEFAVATEKLTVKRPQEVGAAEAAALPVAGLTALQALTNPAGLKLDG 152 Query: 180 PGLRGGIL---GLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGAD---DYVIGS 233 G + IL GGVGH V++AK HVT ++ + E ++ LGAD DY Sbjct: 153 TGKKANILVTAASGGVGHYAVQLAKLANAHVT--ATCGARNIEFVKSLGADEVLDYKTPE 210 Query: 234 DQAKMSELADSLDYVI---DTVPVHHALEPYLSLLKLDGKLILMGVINNPLQ--FLTPLL 288 A S D V+ + +P EP LS +GK+I + N + + + Sbjct: 211 GAALKSPSGKKYDAVVHCANGIPF-SVFEPNLS---ENGKVIDITPGPNAMWTYAVKKIT 266 Query: 289 MLGRKVITGSFIGSMKETEEMLEFCKEKGLSSIIE 323 M ++++ I + E M+ KE + ++I+ Sbjct: 267 MSKKQLVPLLLIPKAENLEFMVNLVKEGKVKTVID 301 >5TNX-A nrPDB Length = 383 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 76/302 (25%), Positives = 119/302 (39%), Gaps = 47/302 (15%) Query: 29 LRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVG 88 +R ++V +R++ G+CHTDL ++ P V GHE G V VG +V G Sbjct: 37 IRAPRGDEVLVRVVATGLCHTDL-IVRDQYYPVPLPAVLGHEGAGVVEAVGPNVKTLAAG 95 Query: 89 DIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYN--DVYINGQP---------------T 131 D V + G CG C+ C YC ++ ++ N +GQ Sbjct: 96 DHVVL--TYGACGHCASCAGGHGAYC-RQFFALNFGGADADGQTALRDAAGEPLHDHFFA 152 Query: 132 QGGFAKATVVHQKFVVKIPEGMAVEQAAPLLC-----AGVTVYSPLSHFGLKQPGLRGGI 186 Q FA + + +K+P+ +E PL C AG + S G G Sbjct: 153 QSSFASYALARENNAIKVPKEAPLELLGPLGCGIQTGAGAVINSLAVRTGSSFASFGAGA 212 Query: 187 LGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQ-DLGADDYVIGSDQAKMSE----- 240 +G+ V M +IA A T+I+ AL +LGA + I S + + + Sbjct: 213 VGMSAV--MAARIAGA----TTIIAVDIVPSRLALALELGA-THAINSKEVDVVDAIREI 265 Query: 241 LADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNP-----LQFLTPLLMLGRKVI 295 +DY +++ + L + L G MGV+ P +F L+LG I Sbjct: 266 TGGGVDYALESTGLPAVLSQGIDALGSRGT---MGVVGAPKLGTKAEFDVNSLLLGGHTI 322 Query: 296 TG 297 G Sbjct: 323 RG 324 >1E3E-A nrPDB Length = 376 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 69/299 (23%), Positives = 122/299 (40%), Gaps = 28/299 (9%) Query: 36 DVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGC 95 +V I++I +C TD++ T + + +P+V GHE G V VG V+ F GD V + Sbjct: 35 EVRIQVIATCVCPTDINAT-DPKKKALFPVVLGHECAGIVESVGPGVTNFKPGDKV-IPF 92 Query: 96 LVGCCGGCSPCERDLEQYCPK----KIWSYNDVYINGQPTQ--------------GGFAK 137 C C C L C K K + + + + ++ F++ Sbjct: 93 FAPQCKRCKLCLSPLTNLCGKLRNFKYPTIDQELMEDRTSRFTCKGRSIYHFMGVSSFSQ 152 Query: 138 ATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGV 197 TVV + + ++ + +E+ + C + Y + PG + GLG VG + Sbjct: 153 YTVVSEANLARVDDEANLERVCLIGCGFSSGYGAAINTAKVTPGSTCAVFGLGCVGLSAI 212 Query: 198 KIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSD-----QAKMSEL-ADSLDYVIDT 251 K G + N ++ + LGA D + + Q ++EL A +DY +D Sbjct: 213 IGCKIAGASRIIAIDINGEKFPKAKALGATDCLNPRELDKPVQDVITELTAGGVDYSLDC 272 Query: 252 VPVHHALEPYLSLLKLD-GKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEM 309 L+ + L G ++G + + T ++LGR I G+F G K + + Sbjct: 273 AGTAQTLKAAVDCTVLGWGSCTVVGAKVDEMTIPTVDVILGRS-INGTFFGGWKSVDSV 330 >2VN8-A nrPDB Length = 375 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 64/231 (27%), Positives = 95/231 (41%), Gaps = 50/231 (21%) Query: 34 PEDVNIRIICCGICHTDLHQTKNDLGMS----NYPMVPGHEVVGEVVEVGSDVSKFTVGD 89 P DVN+R G T L+ ++ L + +P+ G +V G V+E G DV F GD Sbjct: 64 PIDVNMR---SGYGATALNMKRDPLHVKIKGEEFPLTLGRDVSGVVMECGLDVKYFKPGD 120 Query: 90 IVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKI 149 E + W QG ++ VV V Sbjct: 121 ---------------------EVWAAVPPWK-----------QGTLSEFVVVSGNEVSHK 148 Query: 150 PEGMAVEQAAPLLCAGVTVYSPLSHFG----LKQPGLRGGILGL-GGVGHMGVKIAKAMG 204 P+ + QAA L +T +S ++ G G R ILG GGVG +++ KA Sbjct: 149 PKSLTHTQAASLPYVALTAWSAINKVGGLNDKNCTGKRVLILGASGGVGTFAIQVMKAWD 208 Query: 205 HHVTVISSSNKKREEALQDLGAD---DYVIGSDQAKMSELADSLDYVIDTV 252 HVT + S + E ++ LGAD DY GS + ++ L D+++D V Sbjct: 209 AHVTAVCSQDA--SELVRKLGADDVIDYKSGSVEEQLKSL-KPFDFILDNV 256 >3FSR-A nrPDB Length = 352 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 56/200 (28%), Positives = 87/200 (43%), Gaps = 12/200 (6%) Query: 33 GPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVG 92 GP D +R + C +D+H + M+ GHE VGEVVEVGS+V F GD V Sbjct: 23 GPFDAIVRPLAVAPCTSDIHTVFEGAIGERHNMILGHEAVGEVVEVGSEVKDFKPGDRVV 82 Query: 93 VGCLVGCCGGCSPCERDLEQYCPKKI--WSYNDVY--INGQPTQGGFAKATVVHQKFVVK 148 V + S +R Q+ + W +++V + G+ A + H Sbjct: 83 VPAITPDW-RTSEVQRGYHQHSGGMLAGWKFSNVKDGVFGEFFHVNDADMNLAH------ 135 Query: 149 IPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVT 208 +P+ + +E AA ++ +T + Q G ++G+G VG MG+ AK G Sbjct: 136 LPKEIPLE-AAVMIPDMMTTGFHGAELADIQMGSSVVVIGIGAVGLMGIAGAKLRGAGRI 194 Query: 209 VISSSNKKREEALQDLGADD 228 + S EA + GA D Sbjct: 195 IGVGSRPICVEAAKFYGATD 214 >1YKF-A nrPDB Length = 352 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 56/202 (27%), Positives = 87/202 (43%), Gaps = 12/202 (5%) Query: 33 GPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVG 92 GP D +R + C +D+H + M+ GHE VGEVVEVGS+V F GD V Sbjct: 23 GPFDAIVRPLAVAPCTSDIHTVFEGAIGERHNMILGHEAVGEVVEVGSEVKDFKPGDRVV 82 Query: 93 VGCLVGCCGGCSPCERDLEQYCPKKI--WSYNDVY--INGQPTQGGFAKATVVHQKFVVK 148 V + S +R Q+ + W +++V + G+ A + H Sbjct: 83 VPAITPDW-RTSEVQRGYHQHSGGMLAGWKFSNVKDGVFGEFFHVNDADMNLAH------ 135 Query: 149 IPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVT 208 +P+ + +E AA ++ +T + + G +LG+G VG M V AK G Sbjct: 136 LPKEIPLE-AAVMIPDMMTTGFHGAELADIELGATVAVLGIGPVGLMAVAGAKLRGAGRI 194 Query: 209 VISSSNKKREEALQDLGADDYV 230 + S +A + GA D V Sbjct: 195 IAVGSRPVCVDAAKYYGATDIV 216 >4JLW-A nrPDB Length = 399 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 29/80 (36%), Positives = 41/80 (51%), Gaps = 6/80 (7%) Query: 37 VNIRIICCGICHTDLHQTKNDLGMSNYP--MVPGHEVVGEVVEVGSDVSKFTVGDIVGVG 94 V +R++ IC +D H + G + P +V GHE+ GEVVE+G V +GD+V V Sbjct: 37 VILRVVSTNICGSDQHMVR---GRTTAPEGLVLGHEITGEVVEIGRGVETMKIGDLVSVP 93 Query: 95 CLVGCCGGCSPCERDLEQYC 114 V CG C C+ C Sbjct: 94 FNV-ACGHCRTCKEQHTGVC 112 >3FPL-A nrPDB Length = 351 Score = 47.4 bits (111), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 84/209 (40%), Gaps = 24/209 (11%) Query: 32 TGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIV 91 G D +R + C +D+H M+ GHE VGEVVEVGS+V F GD V Sbjct: 22 AGSYDAIVRPLAVSPCTSDIHTVFEGALGDRKNMILGHEAVGEVVEVGSEVKDFKPGDRV 81 Query: 92 GVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFA--KATVVHQKFVVK- 148 V C +P R LE + + + NG F+ K V + F V Sbjct: 82 IVPC-------TTPDWRSLE------VQAGFQQHSNGMLAGWKFSNFKDGVFGEYFHVND 128 Query: 149 -------IPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAK 201 +P+ M +E A ++ +T + + G +LG+G VG M V AK Sbjct: 129 ADMNLAILPKDMPLENAV-MITDMMTTGFHGAELADIELGATVAVLGIGPVGLMAVAGAK 187 Query: 202 AMGHHVTVISSSNKKREEALQDLGADDYV 230 G + S +A + GA D V Sbjct: 188 LRGAGRIIAVGSRPVCVDAAKYYGATDIV 216 >1KEV-A nrPDB Length = 351 Score = 47.4 bits (111), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 59/207 (28%), Positives = 83/207 (40%), Gaps = 24/207 (11%) Query: 32 TGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIV 91 G D +R + C +D+H M+ GHE VGEVVEVGS+V F GD V Sbjct: 22 AGSYDAIVRPLAVSPCTSDIHTVFEGALGDRKNMILGHEAVGEVVEVGSEVKDFKPGDRV 81 Query: 92 GVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFA--KATVVHQKFVVK- 148 V C +P R LE + + + NG F+ K V + F V Sbjct: 82 IVPC-------TTPDWRSLE------VQAGFQQHSNGMLAGWKFSNFKDGVFGEYFHVND 128 Query: 149 -------IPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAK 201 +P+ M +E A + T + + Q G ++G+G VG MG+ AK Sbjct: 129 ADMNLAILPKDMPLENAVMITDMMTTGFHG-AELADIQMGSSVVVIGIGAVGLMGIAGAK 187 Query: 202 AMGHHVTVISSSNKKREEALQDLGADD 228 G + S EA + GA D Sbjct: 188 LRGAGRIIGVGSRPICVEAAKFYGATD 214 >4IDE-A nrPDB Length = 332 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 60/236 (25%), Positives = 98/236 (41%), Gaps = 53/236 (22%) Query: 31 ETGPEDVNIRIICCGICHTDLHQTKNDLGM-----SNYPMVPGHEVVGEVVEVGSDVSKF 85 E + V I+++ + D K LG S P +PG++V G VV+VGS V+KF Sbjct: 49 EIKEDQVLIKVVAASLNPVDF---KRALGYFKDTDSPLPTIPGYDVAGVVVKVGSQVTKF 105 Query: 86 TVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYING--QPTQ-GGFAKATVVH 142 VGD V Y D+ PT+ G A+ T Sbjct: 106 KVGDEV-----------------------------YGDLNETALVNPTRFGSLAEYTAAD 136 Query: 143 QKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGG------ILGLGGVGHMG 196 ++ + P+ ++ +AA L A T +H GL++ L G G H+ Sbjct: 137 ERVLAHKPKNLSFIEAASLPLAIET-----AHEGLERAELSAGKSVLVLGGAGGVGTHI- 190 Query: 197 VKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDYVIDTV 252 +++AK + V ++++ K+ + L+ LGAD I + +L + D V D V Sbjct: 191 IQLAKHVFGASKVAATASTKKLDLLRTLGAD-LAIDYTKENFEDLPEKFDVVYDAV 245 >1KOL-A nrPDB Length = 398 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 25/71 (35%), Positives = 38/71 (53%), Gaps = 2/71 (2%) Query: 37 VNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCL 96 V ++++ IC +D H + + +V GHE+ GEV+E G DV +GD+V V Sbjct: 36 VILKVVSTNICGSDQHMVRGRT-TAQVGLVLGHEITGEVIEKGRDVENLQIGDLVSVPFN 94 Query: 97 VGCCGGCSPCE 107 V CG C C+ Sbjct: 95 V-ACGRCRSCK 104 >3FPC-A nrPDB Length = 352 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 31/94 (32%), Positives = 45/94 (47%), Gaps = 3/94 (3%) Query: 33 GPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVG 92 GP D +R + C +D+H + M+ GHE VGEVVEVGS+V F GD V Sbjct: 23 GPFDAIVRPLAVAPCTSDIHTVFEGAIGERHNMILGHEAVGEVVEVGSEVKDFKPGDRVV 82 Query: 93 VGCLVGCCGGCSPCERDLEQYCPKKI--WSYNDV 124 V + S +R Q+ + W +++V Sbjct: 83 VPAITPDW-RTSEVQRGYHQHSGGMLAGWKFSNV 115 >6DKH-A nrPDB Length = 346 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 52/192 (27%), Positives = 82/192 (42%), Gaps = 10/192 (5%) Query: 39 IRIICCGICHTDLH---QTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGC 95 ++I GIC +DLH + K M PMV GHEV+G+V+ SD S+ G V + Sbjct: 35 VQITRGGICGSDLHYYQEGKVGNFMIKAPMVLGHEVIGKVIH--SDSSELHEGQTVAIN- 91 Query: 96 LVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAV 155 CG C C E C + + +Y GGF + +V V P Sbjct: 92 PSKPCGHCKYCIEHNENQCTDMRFFGSAMYF--PHVDGGFTRYKMVETSQCVPYPAKADE 149 Query: 156 EQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNK 215 + A V +++ +H + G R I G+G +G + V K +G V + + Sbjct: 150 KVMAFAEPLAVAIHA--AHQAGELQGKRVFISGVGPIGCLIVSAVKTLGAAEIVCADVSP 207 Query: 216 KREEALQDLGAD 227 + +++GAD Sbjct: 208 RSLSLGKEMGAD 219 >3M6I-A nrPDB Length = 363 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 67/270 (24%), Positives = 106/270 (39%), Gaps = 42/270 (15%) Query: 36 DVNIRIICCGICHTDLHQTKND-LGMSNYPM------VPGHEVVGEVVEVGSDVSKFTVG 88 +V + + GIC +D+H K+ +G PM V GHE GEV+ V V VG Sbjct: 42 EVTVAVRSTGICGSDVHFWKHGCIG----PMIVECDHVLGHESAGEVIAVHPSVKSIKVG 97 Query: 89 DIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVK 148 D V + V C C PC C + V P G + V H Sbjct: 98 DRVAIEPQV-ICNACEPCLTGRYNGCER-------VDFLSTPPVPGLLRRYVNHPAVWCH 149 Query: 149 IPEGMAVEQAAPLLCAGVTVYSPLS--HFGLKQPGLRGG----ILGLGGVGHMGVKIAKA 202 M+ E A L PLS GL++ G+R G I G G +G + + AKA Sbjct: 150 KIGNMSYENGAML--------EPLSVALAGLQRAGVRLGDPVLICGAGPIGLITMLCAKA 201 Query: 203 MGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSL---------DYVIDTVP 253 G VI+ ++ R + +++ + ++ E A + ++ Sbjct: 202 AGACPLVITDIDEGRLKFAKEICPEVVTHKVERLSAEESAKKIVESFGGIEPAVALECTG 261 Query: 254 VHHALEPYLSLLKLDGKLILMGVINNPLQF 283 V ++ + +K GK+ ++GV N +Q Sbjct: 262 VESSIAAAIWAVKFGGKVFVIGVGKNEIQI 291 >2VCY-A nrPDB Length = 344 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 52/234 (22%), Positives = 96/234 (41%), Gaps = 44/234 (18%) Query: 17 DPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGM-SNYPMVPGHEVVGEV 75 DP+ ++ L DV ++++ I +D++ + + G+ P V G+E V +V Sbjct: 24 DPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGLLPELPAVGGNEGVAQV 83 Query: 76 VEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGF 135 V VGS+V+ GD V I G + Sbjct: 84 VAVGSNVTGLKPGDWV----------------------------------IPANAGLGTW 109 Query: 136 AKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPG---LRGGILGLGGV 192 V ++ ++++P + ++ AA L T Y L F QPG ++ GV Sbjct: 110 RTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNA--SNSGV 167 Query: 193 GHMGVKIAKAMG-HHVTVISSSN--KKREEALQDLGADDYVIGSDQAKMSELAD 243 G ++IA A+G + V+ +K + L+ LGA ++VI ++ + E+ + Sbjct: 168 GQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGA-EHVITEEELRRPEMKN 220 >3JYN-A nrPDB Length = 325 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 57/200 (28%), Positives = 86/200 (43%), Gaps = 46/200 (23%) Query: 33 GPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVP---GHEVVGEVVEVGSDVSKFTVGD 89 GP+ V +R G+ D + G+ P +P G E G V VG +V++F VGD Sbjct: 27 GPQAVVVRNKAIGLNFIDTYYRS---GLYPAPFLPSGLGAEGAGVVEAVGDEVTRFKVGD 83 Query: 90 IVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKI 149 V G G G +Y++V+ V+ + +VK+ Sbjct: 84 RVAYGT--GPLG------------------AYSEVH--------------VLPEANLVKL 109 Query: 150 PEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGIL---GLGGVGHMGVKIAKAMGHH 206 + ++ EQAA L+ G+TV L +PG IL GGVG + + AKA+G Sbjct: 110 ADSVSFEQAAALMLKGLTVQYLLRQTYQVKPGEI--ILFHAAAGGVGSLACQWAKALGAK 167 Query: 207 VTVISSSNKKREEALQDLGA 226 + SS +K A + LGA Sbjct: 168 LIGTVSSPEKAAHA-KALGA 186 >2DPH-A nrPDB Length = 398 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 28/82 (34%), Positives = 40/82 (48%), Gaps = 2/82 (2%) Query: 37 VNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCL 96 V ++++ IC +D H + + V GHE+ GEVVE GSDV +GD+V V Sbjct: 35 VILKVVSTNICGSDQHIYRGRF-IVPKGHVLGHEITGEVVEKGSDVELMDIGDLVSVPFN 93 Query: 97 VGCCGGCSPCERDLEQYCPKKI 118 V CG C C+ C + Sbjct: 94 V-ACGRCRNCKEARSDVCENNL 114 >4A27-A nrPDB Length = 349 Score = 44.7 bits (104), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 65/262 (24%), Positives = 106/262 (40%), Gaps = 53/262 (20%) Query: 29 LRETGPE----DVNIRIICCGICHTDLHQTKNDL-GMSNYPMVPGHEVVGEVVEVGSDVS 83 R+ PE ++ IR+ CG+ DL + ++ P+VPG E G V +G V Sbjct: 21 FRKAMPEPQDGELKIRVKACGLNFIDLMVRQGNIDNPPKTPLVPGFECSGIVEALGDSVK 80 Query: 84 KFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQ 143 + +GD V +YN +A+ Sbjct: 81 GYEIGDRV------------------------MAFVNYN-----------AWAEVVCTPV 105 Query: 144 KFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGL-----GGVGHMGVK 198 +FV KIP+ M+ +AA VT Y L + LR G+ L GGVG + Sbjct: 106 EFVYKIPDDMSFSEAAAFPMNFVTAYVML----FEVANLREGMSVLVHSAGGGVGQAVAQ 161 Query: 199 IAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL--ADSLDYVIDTVPVHH 256 + + +VTV +++ + EA++D + +D + + A+ +D V+D + + Sbjct: 162 LCSTV-PNVTVFGTASTFKHEAIKDSVTHLFDRNADYVQEVKRISAEGVDIVLDCLCGDN 220 Query: 257 ALEPYLSLLKLDGKLILMGVIN 278 + LSLLK G IL G N Sbjct: 221 TGKG-LSLLKPLGTYILYGSSN 241 >2OUI-A nrPDB Length = 360 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 23/61 (37%), Positives = 32/61 (52%) Query: 31 ETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDI 90 E GP D +R + C +D H + M+ GHE VG++V+VGS V + VGD Sbjct: 21 ECGPLDALVRPLALAPCTSDTHTVWAGAIGDRHDMILGHEAVGQIVKVGSLVKRLKVGDK 80 Query: 91 V 91 V Sbjct: 81 V 81 >3B70-A nrPDB Length = 371 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 33/101 (32%), Positives = 45/101 (44%), Gaps = 28/101 (27%) Query: 68 GHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYIN 127 G + G VV VGSDV+ VGD V G + CP+ Sbjct: 67 GTDYAGTVVAVGSDVTHIQVGDRV-----YGA----------QNEMCPRT---------- 101 Query: 128 GQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTV 168 P QG F++ TV + KIP+G++ EQAA L AG++ Sbjct: 102 --PDQGAFSQYTVTRGRVWAKIPKGLSFEQAA-ALPAGIST 139 >2OBY-A nrPDB Length = 338 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 59/260 (22%), Positives = 113/260 (43%), Gaps = 37/260 (14%) Query: 119 WSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLK 178 W D + P GG A+ V + ++ IPEG+ + QAA + A +T + L G Sbjct: 86 WKIGDTAMALLPG-GGQAQYVTVPEGLLMPIPEGLTLTQAAAIPEAWLTAFQLLHLVGNV 144 Query: 179 QPGLRGGI-LGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGA--------DDY 229 Q G I GL GVG +++ + M + ++++ ++K+ + + LGA +D+ Sbjct: 145 QAGDYVLIHAGLSGVGTAAIQLTR-MAGAIPLVTAGSQKKLQMAEKLGAAAGFNYKKEDF 203 Query: 230 VIGSDQAKMSELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGV-----INNPLQFL 284 S+ ++ ++D + + E ++ L LDG+ +L G+ IN P L Sbjct: 204 ---SEATLKFTKGAGVNLILDCIGGSY-WEKNVNCLALDGRWVLYGLMGGGDINGP---L 256 Query: 285 TPLLMLGRKVITGSFIGSMKE----------TEEMLEFCKEKGLSSIIEVVKMDY----V 330 L+ R + S + S TE++L +G ++ V+ Y + Sbjct: 257 FSKLLFKRGSLITSLLRSRDNKYKQMLVNAFTEQILPHFSTEGPQRLLPVLDRIYPVTEI 316 Query: 331 NTAFERLEKNDVRYRFVVDV 350 A + +E N + V+++ Sbjct: 317 QEAHKYMEANKNIGKIVLEL 336 >4Y1B-A nrPDB Length = 425 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 48/229 (20%), Positives = 92/229 (40%), Gaps = 25/229 (10%) Query: 33 GPEDVNIRIICCGICHT----------DLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDV 82 GP V ++++ G+ + D+ + G + + G ++ G V VG V Sbjct: 69 GPGQVLVKVMAAGVNYNNVWAALGEPLDVIAARQKQGATEDFHIGGSDLSGIVWAVGDGV 128 Query: 83 SKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVH 142 ++V + C D +++W Y + Y G FA+ VV Sbjct: 129 RLKPGAEVVVLACRWDESAQDIRLGADPVTSSTQRVWGYEENY-------GSFAQFAVVD 181 Query: 143 QKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGG--IL---GLGGVGHMGV 197 + P+ ++ A+ + T Y L FG + +R G +L G GG+G + + Sbjct: 182 EYMCHPKPQRLSWAAASCYMATAATAYRQL--FGWEPHTVRPGDPVLIWGGAGGLGSIAI 239 Query: 198 KIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLD 246 ++ + +G + V S+++R E LGA ++ + L D+ D Sbjct: 240 QLVRHVG-GIPVAVVSSEERGEFCMRLGAKGWIDRREFDHWGRLPDTTD 287 >1YB5-A nrPDB Length = 351 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 55/253 (21%), Positives = 101/253 (39%), Gaps = 49/253 (19%) Query: 34 PED--VNIRIICCGICHTDLHQTKNDLGMSNY-PMVPGHEVVGEVVEVGSDVSKFTVGDI 90 P+D V I++ CG+ + + P PG +V G + VG + S F GD Sbjct: 55 PKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGD- 113 Query: 91 VGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIP 150 ++++ + + GG+A+ + V K+P Sbjct: 114 --------------------------RVFTSSTI-------SGGYAEYALAADHTVYKLP 140 Query: 151 EGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGL-GGVGHMGVKIAKAMGHHVTV 209 E + +Q A + T Y L H + G + G GGVG +IA+A G + Sbjct: 141 EKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILG 200 Query: 210 ISSSNKKREEALQDLGAD-------DYVIGSDQAKMSELADSLDYVIDTVPVHHALEPYL 262 + + + ++ LQ+ + +Y+ D+ K +D +I+ + + L L Sbjct: 201 TAGTEEGQKIVLQNGAHEVFNHREVNYI---DKIKKYVGEKGIDIIIEML-ANVNLSKDL 256 Query: 263 SLLKLDGKLILMG 275 SLL G++I++G Sbjct: 257 SLLSHGGRVIVVG 269 >1O89-A nrPDB Length = 345 Score = 35.8 bits (81), Expect = 0.026, Method: Compositional matrix adjust. Identities = 52/201 (25%), Positives = 80/201 (39%), Gaps = 42/201 (20%) Query: 34 PE-DVNIRIICCGICHTD-LHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIV 91 PE DV + + + + D L T + N+PM+PG + G V S+ +F G V Sbjct: 47 PEGDVTVDVHWSSLNYKDALAITGKGKIIRNFPMIPGIDFAGTVRT--SEDPRFHAGQEV 104 Query: 92 GVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPE 151 L G W G+ GG A+ V ++V +P+ Sbjct: 105 ---LLTG--------------------WGV------GENHWGGLAEQARVKGDWLVAMPQ 135 Query: 152 GMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLR---GGIL---GLGGVGHMGVKIAKAMGH 205 G+ +A + AG T L L+ G+R G I+ GGVG V + +G+ Sbjct: 136 GLDARKAMIIGTAGFTAM--LCVMALEDAGVRPQDGEIVVTGASGGVGSTAVALLHKLGY 193 Query: 206 HVTVISSSNKKREEALQDLGA 226 V + S + E L+ LGA Sbjct: 194 QVVAV-SGRESTHEYLKSLGA 213 >5GXF-A nrPDB Length = 330 Score = 35.8 bits (81), Expect = 0.030, Method: Compositional matrix adjust. Identities = 31/109 (28%), Positives = 50/109 (45%), Gaps = 9/109 (8%) Query: 128 GQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGL---RG 184 G+ GG+++ V ++V +PEG+ QA + AG T L+ L+ GL G Sbjct: 94 GEAHWGGYSQKANVRADWLVPLPEGLDTRQAMAVGTAGFTAM--LAVMALEDHGLTPGHG 151 Query: 185 GIL---GLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYV 230 +L GGVG + I +G+ V + + + + L LGA V Sbjct: 152 PVLVTGAAGGVGSVATAILAHLGYEVAAV-TGRPETADYLTSLGATQIV 199 >4DVJ-A nrPDB Length = 363 Score = 34.7 bits (78), Expect = 0.069, Method: Compositional matrix adjust. Identities = 40/174 (22%), Positives = 77/174 (44%), Gaps = 16/174 (9%) Query: 133 GGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPL-SHFGLKQP--GLRGGIL-- 187 G A+ +V ++ V + P+ + +AA L +T + + +P G IL Sbjct: 119 GTNAEFHLVDERIVGRKPKTLDWAEAAALPLTSITAWEAFFDRLDVNKPVPGAAPAILIV 178 Query: 188 -GLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELAD--- 243 G GGVG + V+IA+ + ++S + +E ++ LGA +VI + +E+A Sbjct: 179 GGAGGVGSIAVQIARQRTDLTVIATASRPETQEWVKSLGA-HHVIDHSKPLAAEVAALGL 237 Query: 244 -SLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVIT 296 + +V T L+ G+ L I++P F +++ RK ++ Sbjct: 238 GAPAFVFSTTHTDKHAAEIADLIAPQGRFCL---IDDPSAF--DIMLFKRKAVS 286 >1WLY-A nrPDB Length = 333 Score = 34.7 bits (78), Expect = 0.074, Method: Compositional matrix adjust. Identities = 51/210 (24%), Positives = 84/210 (40%), Gaps = 43/210 (20%) Query: 33 GPEDVNIRIICCGICHTDLHQTK---NDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGD 89 GP V +R G+ D + + L + P+V G E V EVG V+ FTVG+ Sbjct: 27 GPGQVRLRNTAIGVNFLDTYHRAGIPHPLVVGEPPIVVGFEAAAVVEEVGPGVTDFTVGE 86 Query: 90 IVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKI 149 V CL P G +++ + + ++K+ Sbjct: 87 RV-CTCL---------------------------------PPLGAYSQERLYPAEKLIKV 112 Query: 150 PEGMAVEQA--APLLCAGVTVYSPLSHFGLKQPGLRGGI-LGLGGVGHMGVKIAKAMGHH 206 P+ + ++ A L+ G+T L +PG I GG+GH+ V A+ +G Sbjct: 113 PKDLDLDDVHLAGLMLKGMTAQYLLHQTHKVKPGDYVLIHAAAGGMGHIMVPWARHLG-- 170 Query: 207 VTVISS-SNKKREEALQDLGADDYVIGSDQ 235 TVI + S +++ E + LG + S Q Sbjct: 171 ATVIGTVSTEEKAETARKLGCHHTINYSTQ 200 >4RVS-A nrPDB Length = 329 Score = 34.3 bits (77), Expect = 0.096, Method: Compositional matrix adjust. Identities = 47/169 (27%), Positives = 74/169 (43%), Gaps = 22/169 (13%) Query: 132 QGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQ--PGLRGGIL-- 187 G +A+ K+P+ + E AA L G+T +H+ LK P RG + Sbjct: 94 NGAYAEFCTAPASLTAKVPDDVTSEVAASALLKGLT-----AHYLLKSVYPVKRGDTVLV 148 Query: 188 --GLGGVGHMGVKIAKAMGHHV-TVISSSNKKREEALQDLGAD---DYVIGSDQ--AKMS 239 G GGVG + + A +G V T +S++ K + +D GAD DY + Q ++ Sbjct: 149 HAGAGGVGLILTQWATHLGVRVITTVSTAEKAKLS--KDAGADVVLDYPEDAWQFAGRVR 206 Query: 240 ELA--DSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTP 286 EL + V D V + L+ L + G L L G + P+ + P Sbjct: 207 ELTGGTGVQAVYDGVGA-TTFDASLASLAVRGTLALFGAASGPVPPVDP 254 >6BII-A nrPDB Length = 333 Score = 33.1 bits (74), Expect = 0.17, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 46/103 (44%), Gaps = 14/103 (13%) Query: 169 YSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADD 228 + P G G GI+G G +G K AK G + ++ ++ ++ EA ++LGA Sbjct: 138 WHPKMFLGYDVYGKTIGIVGFGRIGQAIAKRAKGFG--MRILYTARSRKPEAEKELGA-- 193 Query: 229 YVIGSDQAKMSELADSLDYVIDTVPV-----HHALEPYLSLLK 266 + + EL D+V+ VP+ H E L L+K Sbjct: 194 -----EFKPLEELLRESDFVVLAVPLTKETYHMINEERLRLMK 231 >3SLK-A nrPDB Length = 795 Score = 33.1 bits (74), Expect = 0.20, Method: Compositional matrix adjust. Identities = 23/84 (27%), Positives = 38/84 (45%), Gaps = 5/84 (5%) Query: 135 FAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGIL---GLGG 191 F V + V +IP G + +AA + +T Y L +PG +L GG Sbjct: 300 FGPLAVADHRMVTRIPAGWSFARAASVPIVFLTAYYALVDLAGLRPG--ESLLVHSAAGG 357 Query: 192 VGHMGVKIAKAMGHHVTVISSSNK 215 VG +++A+ +G V +S +K Sbjct: 358 VGMAAIQLARHLGAEVYATASEDK 381 >5LB9-A nrPDB Length = 385 Score = 33.1 bits (74), Expect = 0.20, Method: Compositional matrix adjust. Identities = 44/188 (23%), Positives = 70/188 (37%), Gaps = 30/188 (15%) Query: 64 PMVP-GHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYN 122 P P G+E + EV++VGS+VS GD V P + + + + + Sbjct: 93 PAAPCGNEGLFEVIKVGSNVSSLEAGDWV------------IPSHVNFGTWRTHALGNDD 140 Query: 123 DVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGL 182 D F K Q P G+ + Q A + + Y L+H+ PG Sbjct: 141 D-----------FIKLPNPAQSKANGKPNGLTINQGATISVNPLVAYLMLTHYVKLTPGK 189 Query: 183 RGGIL--GLGGVGHMGVKIAKAMGHHVTVISSSNKKREE---ALQDLGADDYVIGSDQAK 237 I G VG +I K + + + +E +L++LGA VI DQ Sbjct: 190 DWFIQNGGTSAVGKYASQIGKLLNFNSISVIRDRPNLDEVVASLKELGATQ-VITEDQNN 248 Query: 238 MSELADSL 245 E ++ Sbjct: 249 SREFGPTI 256 >5NGJ-A nrPDB Length = 477 Score = 32.3 bits (72), Expect = 0.33, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 25/46 (54%) Query: 276 VINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSSI 321 INN + +LTP +M + GSF G+ + T + + +K L S+ Sbjct: 232 TINNNITYLTPNVMSRVTIPIGSFTGAFELTGSLTAYLNDKSLGSM 277 >2CDC-A nrPDB Length = 366 Score = 32.0 bits (71), Expect = 0.40, Method: Compositional matrix adjust. Identities = 27/83 (32%), Positives = 34/83 (40%), Gaps = 9/83 (10%) Query: 37 VNIRIICCGICHTDLHQTKNDLGMSNYP-----MVPGHEVVGEVVEVGSDVSKFTVGDIV 91 + IR I GIC D L +S P +V GHE +G V E F+ GD+V Sbjct: 29 IKIRTIYNGICGADREIVNGKLTLSTLPKGKDFLVLGHEAIGVVEE---SYHGFSQGDLV 85 Query: 92 GVGCLVGCCGGCSPCERDLEQYC 114 G CG C C +C Sbjct: 86 MPVNRRG-CGICRNCLVGRPDFC 107 >2EEZ-A nrPDB Length = 369 Score = 32.0 bits (71), Expect = 0.40, Method: Compositional matrix adjust. Identities = 27/78 (34%), Positives = 36/78 (46%), Gaps = 2/78 (2%) Query: 186 ILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQD-LGADDYVIGSDQAKMSELADS 244 ILG G VG KIA MG VT++ N KR + L D G + + +A + + Sbjct: 171 ILGGGTVGTNAAKIALGMGAQVTIL-DVNHKRLQYLDDVFGGRVITLTATEANIKKSVQH 229 Query: 245 LDYVIDTVPVHHALEPYL 262 D +I V V A P L Sbjct: 230 ADLLIGAVLVPGAKAPKL 247 >4A10-A nrPDB Length = 447 Score = 31.6 bits (70), Expect = 0.49, Method: Compositional matrix adjust. Identities = 37/142 (26%), Positives = 64/142 (45%), Gaps = 17/142 (11%) Query: 116 KKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAA-PLLCAGVTVYSPLSH 174 ++ W + + GG A+ VV ++ P + E+AA LCAG +S Sbjct: 161 QRAWGFETNF-------GGLAEYGVVRASQLLPKPAHLTWEEAAVSPLCAGTAYRMLVSD 213 Query: 175 FGLKQPGLRGGIL----GLGGVGHMGVKIAK-AMGHHVTVISSSNKKREEALQDLGADDY 229 G + +G I+ GG+G ++ K G V V+SS+ K E A++ LG D Sbjct: 214 RGAQMK--QGDIVLIWGASGGLGSYAIQFVKNGGGIPVAVVSSAQK--EAAVRALGCDLV 269 Query: 230 VIGSDQAKMSELADSLDYVIDT 251 + ++ ++AD V++T Sbjct: 270 INRAELGITDDIADDPRRVVET 291 >5AOV-A nrPDB Length = 336 Score = 31.6 bits (70), Expect = 0.52, Method: Compositional matrix adjust. Identities = 22/86 (25%), Positives = 41/86 (47%), Gaps = 9/86 (10%) Query: 169 YSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADD 228 + P G + G GI+G G +G + AK G ++ ++ S ++ +A ++LGA Sbjct: 138 WHPKWFLGYELYGKTIGIVGFGRIGQAIARRAK--GFNMRILYYSRTRKSQAEKELGA-- 193 Query: 229 YVIGSDQAKMSELADSLDYVIDTVPV 254 + + E+ D+VI VP+ Sbjct: 194 -----EYRPLEEVLKESDFVILAVPL 214 >2WEK-A nrPDB Length = 341 Score = 31.2 bits (69), Expect = 0.73, Method: Compositional matrix adjust. Identities = 30/100 (30%), Positives = 41/100 (41%), Gaps = 12/100 (12%) Query: 133 GGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGG-----IL 187 G FA+ TVV +P + LL +G T Y L G GL G Sbjct: 97 GSFAEYTVVPASIATPVPS--VKPEYLTLLVSGTTAYISLKELG----GLSEGKKVLVTA 150 Query: 188 GLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGAD 227 GG G ++++K HV SS++K L+ LG D Sbjct: 151 AAGGTGQFAMQLSKKAKCHVIGTCSSDEK-SAFLKSLGCD 189 >1QOR-A nrPDB Length = 327 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 43/203 (21%), Positives = 73/203 (35%), Gaps = 35/203 (17%) Query: 21 ILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGS 80 +L +T + ++ + GI D + + P G E G V +VGS Sbjct: 15 VLQAVEFTPADPAENEIQVENKAIGINFIDTYIRSGLYPPPSLPSGLGTEAAGIVSKVGS 74 Query: 81 DVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATV 140 V GD V Y + +Y+ V+ + Sbjct: 75 GVKHIKAGDRV--------------------VYAQSALGAYSSVH-------------NI 101 Query: 141 VHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGI-LGLGGVGHMGVKI 199 + K + +P ++ EQAA G+TVY L +P + GGVG + + Sbjct: 102 IADKAAI-LPAAISFEQAAASFLKGLTVYYLLRKTYEIKPDEQFLFHAAAGGVGLIACQW 160 Query: 200 AKAMGHHVTVISSSNKKREEALQ 222 AKA+G + + +K + AL+ Sbjct: 161 AKALGAKLIGTVGTAQKAQSALK 183 >2QYS-A nrPDB Length = 318 Score = 30.4 bits (67), Expect = 1.2, Method: Compositional matrix adjust. Identities = 25/105 (23%), Positives = 48/105 (45%), Gaps = 9/105 (8%) Query: 176 GLKQPGLRGGILGLGG---VGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIG 232 G+++ G++ IL GG +G+ VK + +GH V + N + L + + +I Sbjct: 4 GMEENGMKSKILIFGGTGYIGNHMVKGSLKLGHPTYVFTRPNSSKTTLLDEFQSLGAIIV 63 Query: 233 S----DQAKMSELADSLDYVIDTVPVHHALEPY--LSLLKLDGKL 271 + K+ EL +D VI + L+ + L +K+ G + Sbjct: 64 KGELDEHEKLVELMKKVDVVISALAFPQILDQFKILEAIKVAGNI 108 >4EYE-A nrPDB Length = 342 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 31/102 (30%), Positives = 43/102 (42%), Gaps = 16/102 (15%) Query: 1 MGIMEAERKTTG-------WAARDPSGILSPYTYTLRET---GPEDVNIRIICCGICHTD 50 MG +EA+ + G + P G++ YT ET GP V + + G+C D Sbjct: 9 MGTLEAQTQGPGSMKAIQAQSLSGPEGLV----YTDVETPGAGPNVVVVDVKAAGVCFPD 64 Query: 51 LHQTKNDLGMS-NYPMVPGHEVVGEVVEVGSDVSKFTVGDIV 91 TK + + P VPG E G VV + S GD V Sbjct: 65 YLMTKGEYQLKMEPPFVPGIETAG-VVRSAPEGSGIKPGDRV 105 >5N2I-A nrPDB Length = 232 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 39/102 (38%), Positives = 50/102 (49%), Gaps = 15/102 (14%) Query: 189 LGGVGHMGVKIAK--AM-GHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSL 245 LGG G G +A+ AM GH V + S S ++ + +LG V G D A +E Sbjct: 25 LGGTGDQGRGLARRFAMAGHEVILGSRSAERAQAVAAELGEGLPVRGMDNAGAAEAG--- 81 Query: 246 DYVIDTVPV--HHALEPYLSLLK--LDGKLILMGVINNPLQF 283 D VI VP H AL L LK L GK+++ V NPL F Sbjct: 82 DVVIVAVPWDGHRAL---LESLKDVLAGKIVVDCV--NPLGF 118 >4IZO-A nrPDB Length = 419 Score = 29.6 bits (65), Expect = 2.0, Method: Compositional matrix adjust. Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 6/71 (8%) Query: 180 PGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGS--DQAK 237 PG G++G G +G M A+AMG+ V V+ A+ AD ++ + D+A Sbjct: 34 PGAWLGMVGGGQLGRMFCFAAQAMGYRVAVLDPDPTSPAGAV----ADKHLRAAYDDEAA 89 Query: 238 MSELADSLDYV 248 ++ELA D V Sbjct: 90 LAELAQLCDAV 100 >4JRO-A nrPDB Length = 271 Score = 29.6 bits (65), Expect = 2.2, Method: Compositional matrix adjust. Identities = 19/83 (22%), Positives = 37/83 (44%), Gaps = 9/83 (10%) Query: 19 SGILSPYTYTLRETGPEDVNIRIICCGICHTDL-----HQTKNDLGMSNYPMVP---GHE 70 +G++ T RE P +N+ + G TD+ +TK + ++ P+ + Sbjct: 184 AGVIGLTKTTARELAPRGINVNAVAPGFITTDMTDKLDEKTKEAM-LAQIPLGAYGTTED 242 Query: 71 VVGEVVEVGSDVSKFTVGDIVGV 93 + V+ + SD SK+ G + V Sbjct: 243 IANAVLFLASDASKYITGQTLSV 265 >6BMA-A nrPDB Length = 261 Score = 29.3 bits (64), Expect = 2.7, Method: Compositional matrix adjust. Identities = 20/66 (30%), Positives = 38/66 (57%), Gaps = 2/66 (3%) Query: 261 YLSLLKLDGKLILM--GVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGL 318 YLSL++ ++ L+ I + Q L L+ V+ + + SMKE +++LEF + GL Sbjct: 106 YLSLIRRYTQIPLLRKDFIFDEYQILEALVYGADFVLLIAKMLSMKELKKLLEFARHLGL 165 Query: 319 SSIIEV 324 +++E+ Sbjct: 166 EALVEI 171 >4WGX-A nrPDB Length = 465 Score = 28.9 bits (63), Expect = 3.2, Method: Compositional matrix adjust. Identities = 24/92 (26%), Positives = 44/92 (47%), Gaps = 8/92 (8%) Query: 250 DTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVIT--GSFIGS-MKET 306 D + VH P + + GK IL G++N + L ++M+GR I F G+ K Sbjct: 40 DQIEVH----PNIRQIDAQGKWILPGLVNGNVHLLDGIMMMGRGGIEYLARFEGNYYKVI 95 Query: 307 EEMLEFCKEKGLSSIIEVVK-MDYVNTAFERL 337 EE + G++++ + ++ V A +R+ Sbjct: 96 EEAAQIALRGGVTTVFDTWNALEPVTIARDRI 127 >5J3E-A nrPDB Length = 225 Score = 28.1 bits (61), Expect = 6.1, Method: Compositional matrix adjust. Identities = 17/56 (30%), Positives = 30/56 (53%), Gaps = 5/56 (8%) Query: 292 RKVITGSFIGSMKETEEMLEF---CKEKGLSSIIEVVKMDYVNTAFERLEKNDVRY 344 R +F+ +MK EE + CKE G++ ++++VK Y + + EKN+ Y Sbjct: 94 RNYQARNFLRAMKLGEEAFFYHSNCKEPGIAGLMKIVKEAYPDHT--QFEKNNPHY 147 >4NBV-A nrPDB Length = 246 Score = 28.1 bits (61), Expect = 6.4, Method: Compositional matrix adjust. Identities = 11/28 (39%), Positives = 17/28 (60%) Query: 30 RETGPEDVNIRIICCGICHTDLHQTKND 57 RE GP+ V + +C G +T++ QT D Sbjct: 170 RELGPKGVRVNAVCPGFVNTEILQTVPD 197 >5OL2-B nrPDB Length = 260 Score = 28.1 bits (61), Expect = 6.7, Method: Compositional matrix adjust. Identities = 15/44 (34%), Positives = 28/44 (63%), Gaps = 3/44 (6%) Query: 196 GVKIAKAMGHHVTVISSSNKKREEALQD---LGADDYVIGSDQA 236 +K+ + MG HVTVI+ + + AL++ +GAD ++ +D+A Sbjct: 45 AIKLKEEMGAHVTVITMGPPQADMALKEALAMGADRGILLTDRA 88 >5JJC-A nrPDB Length = 342 Score = 28.1 bits (61), Expect = 6.8, Method: Compositional matrix adjust. Identities = 17/57 (29%), Positives = 37/57 (64%), Gaps = 8/57 (14%) Query: 176 GLKQPGLRGGILGLGGVGHMGV---KIAKAMGHHVTVI--SSSNKKREEALQDLGAD 227 GL +PG G++ G G+ G+ +AKA+G+ ++ ++++++++AL+ LGA+ Sbjct: 57 GLLRPG---GVIVEGTAGNTGIGLTMVAKALGYRTAIVIPETASQEKKDALRLLGAE 110 >1NVT-A nrPDB Length = 287 Score = 27.7 bits (60), Expect = 8.7, Method: Compositional matrix adjust. Identities = 18/56 (32%), Positives = 31/56 (55%), Gaps = 6/56 (10%) Query: 243 DSLDYVIDTVPV----HHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKV 294 D +D +I+ P+ + +EP + KL +++M +I NPL+ T LL +KV Sbjct: 192 DGVDIIINATPIGMYPNIDVEPIVKAEKLREDMVVMDLIYNPLE--TVLLKEAKKV 245 >2NRJ-A nrPDB Length = 346 Score = 27.3 bits (59), Expect = 9.1, Method: Compositional matrix adjust. Identities = 14/51 (27%), Positives = 29/51 (56%), Gaps = 3/51 (5%) Query: 197 VKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDY 247 K+ ++GH V S+ + + L++ GAD + +DQ ++ E+ S++Y Sbjct: 147 TKLRDSIGHDVRAFGSNKELLQSILKNQGAD---VDADQKRLEEVLGSVNY 194 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2CF5-A nrPDB 466 e-131 1YQX-A nrPDB 401 e-112 5Z0C-A nrPDB 396 e-111 5VKT-A nrPDB 357 4e-99 5FI5-A nrPDB 355 3e-98 5H82-A nrPDB 352 2e-97 5H83-A nrPDB 348 2e-96 3MEQ-A nrPDB 348 3e-96 3PII-A nrPDB 347 5e-96 3TWO-A nrPDB 335 3e-92 1UUF-A nrPDB 332 1e-91 6N7L-A nrPDB 332 1e-91 1LLU-A nrPDB 329 1e-90 4Z6K-A nrPDB 323 9e-89 3S2F-A nrPDB 320 6e-88 1HSZ-A nrPDB 305 3e-83 1U3W-A nrPDB 303 5e-83 1HSO-A nrPDB 303 7e-83 4OAQ-A nrPDB 300 7e-82 4EEZ-A nrPDB 300 9e-82 4DLA-A nrPDB 296 1e-80 3COS-A nrPDB 291 3e-79 1EE2-A nrPDB 288 4e-78 2EER-A nrPDB 286 8e-78 4JJI-A nrPDB 286 1e-77 1MC5-A nrPDB 283 1e-76 5ENV-A nrPDB 283 1e-76 1CDO-A nrPDB 282 1e-76 6C49-A nrPDB 278 3e-75 1D1T-A nrPDB 278 4e-75 4RQU-A nrPDB 277 5e-75 1Q1N-A nrPDB 275 2e-74 1E3E-A nrPDB 273 1e-73 4GKV-A nrPDB 272 1e-73 5YAT-A nrPDB 270 7e-73 1R37-A nrPDB 268 3e-72 1H2B-A nrPDB 267 5e-72 1P0F-A nrPDB 260 6e-70 5K1S-A nrPDB 255 2e-68 2DFV-A nrPDB 249 1e-66 5YLN-A nrPDB 249 2e-66 2H6E-A nrPDB 247 7e-66 1F8F-A nrPDB 246 8e-66 3GFB-A nrPDB 242 2e-64 6FG0-A nrPDB 236 1e-62 3WLE-A nrPDB 236 1e-62 1PL8-A nrPDB 229 1e-60 5TNX-A nrPDB 229 2e-60 1E3J-A nrPDB 229 2e-60 5KIA-A nrPDB 226 2e-59 3QE3-A nrPDB 224 5e-59 2DQ4-A nrPDB 223 8e-59 5VM2-A nrPDB 221 3e-58 4EJ6-A nrPDB 221 4e-58 4ILK-A nrPDB 217 4e-57 4CPD-A nrPDB 217 8e-57 3UOG-A nrPDB 214 6e-56 4OH1-A nrPDB 208 4e-54 4UEJ-A nrPDB 205 2e-53 1YKF-A nrPDB 201 3e-52 3FSR-A nrPDB 198 4e-51 6DKH-A nrPDB 195 3e-50 3FPL-A nrPDB 192 2e-49 3IP1-A nrPDB 191 4e-49 1KEV-A nrPDB 189 2e-48 3M6I-A nrPDB 188 4e-48 3FPC-A nrPDB 184 7e-47 4Y1B-A nrPDB 168 3e-42 2OUI-A nrPDB 167 6e-42 3FBG-A nrPDB 167 8e-42 3TQH-A nrPDB 166 1e-41 4A27-A nrPDB 161 5e-40 2VCY-A nrPDB 159 2e-39 2OBY-A nrPDB 159 2e-39 2VN8-A nrPDB 157 6e-39 3JYN-A nrPDB 154 7e-38 4IDE-A nrPDB 147 1e-35 5A3V-A nrPDB 138 3e-33 2DPH-A nrPDB 127 6e-30 4JLW-A nrPDB 125 3e-29 1KOL-A nrPDB 122 2e-28 3B70-A nrPDB 112 4e-25 Sequences not found previously or not previously below threshold: 4J6F-A nrPDB 150 6e-37 1YB5-A nrPDB 147 5e-36 1QOR-A nrPDB 139 1e-33 4A10-A nrPDB 138 3e-33 1WLY-A nrPDB 136 1e-32 3HZZ-A nrPDB 135 3e-32 3QWB-A nrPDB 133 7e-32 4DVJ-A nrPDB 131 6e-31 4RVS-A nrPDB 128 4e-30 4EYE-A nrPDB 123 1e-28 2WEK-A nrPDB 115 3e-26 3SLK-A nrPDB 112 2e-25 2VWH-A nrPDB 99 4e-21 2CDC-A nrPDB 96 3e-20 5LB9-A nrPDB 91 7e-19 1V3V-A nrPDB 87 1e-17 3WID-A nrPDB 85 3e-17 1O89-A nrPDB 85 5e-17 5GXF-A nrPDB 80 1e-15 2J3K-A nrPDB 76 3e-14 2Y05-A nrPDB 71 9e-13 1SEZ-A nrPDB 45 5e-05 2VHY-A nrPDB 45 6e-05 6BII-A nrPDB 44 1e-04 2EEZ-A nrPDB 43 2e-04 5AOV-A nrPDB 41 9e-04 1DXY-A nrPDB 41 9e-04 1ZCJ-A nrPDB 40 0.001 2RIR-A nrPDB 40 0.001 1XLT-A nrPDB 40 0.002 3ZWA-A nrPDB 40 0.002 4DIO-A nrPDB 39 0.002 3MGG-A nrPDB 37 0.013 2WWR-A nrPDB 37 0.013 5ILO-A nrPDB 37 0.016 2YVG-A nrPDB 37 0.016 2EGU-A nrPDB 37 0.018 1JG3-A nrPDB 37 0.020 3GG9-A nrPDB 36 0.027 1LSS-A nrPDB 36 0.029 2C2Y-A nrPDB 36 0.030 1CYD-A nrPDB 36 0.030 6C55-A nrPDB 35 0.035 3D3W-A nrPDB 35 0.039 3EMK-A nrPDB 35 0.042 2BRY-A nrPDB 35 0.044 4TXK-A nrPDB 35 0.051 1X14-A nrPDB 35 0.056 3VPX-A nrPDB 35 0.059 3OAM-A nrPDB 35 0.074 4FHN-X nrPDB 34 0.083 5IJZ-A nrPDB 34 0.088 5JJC-A nrPDB 34 0.091 3GRP-A nrPDB 34 0.092 2EKL-A nrPDB 34 0.093 4K28-A nrPDB 34 0.096 3AOE-A nrPDB 34 0.097 3X2F-A nrPDB 34 0.11 1V9L-A nrPDB 34 0.12 5NMX-A nrPDB 34 0.12 4IZO-A nrPDB 34 0.12 2YFH-A nrPDB 33 0.13 6C36-A nrPDB 33 0.16 1E3W-A nrPDB 33 0.17 1A5Z-A nrPDB 33 0.17 3HM2-A nrPDB 33 0.20 4XGI-A nrPDB 33 0.21 5ZZ6-A nrPDB 33 0.22 1ZFN-A nrPDB 33 0.23 3PPI-A nrPDB 33 0.25 5VMT-A nrPDB 33 0.25 3NJ4-A nrPDB 33 0.27 4OMU-A nrPDB 33 0.28 4E4T-A nrPDB 32 0.30 1CRW-G nrPDB 32 0.34 1EUZ-A nrPDB 32 0.34 1ZEJ-A nrPDB 32 0.35 1XDW-A nrPDB 32 0.40 1HL3-A nrPDB 32 0.42 3OC4-A nrPDB 32 0.44 2ZJ1-A nrPDB 32 0.46 3K92-A nrPDB 32 0.49 5T5Q-A nrPDB 32 0.52 1VH3-A nrPDB 32 0.53 5JFC-L nrPDB 32 0.57 5U9P-A nrPDB 32 0.60 2O23-A nrPDB 32 0.60 3EZY-A nrPDB 32 0.62 6APH-A nrPDB 32 0.62 3HWR-A nrPDB 32 0.62 5VJ7-A nrPDB 32 0.64 4ZGS-A nrPDB 31 0.66 3L9X-A nrPDB 31 0.68 6ER9-A nrPDB 31 0.85 1NVM-B nrPDB 31 0.86 5UOG-A nrPDB 31 0.95 1NYT-A nrPDB 31 0.99 4DGS-A nrPDB 31 1.0 1QP8-A nrPDB 31 1.0 4XIJ-A nrPDB 31 1.1 3DC2-A nrPDB 30 1.1 6GBN-A nrPDB 30 1.2 3K8Z-A nrPDB 30 1.2 1OBF-O nrPDB 30 1.3 4RG3-A nrPDB 30 1.4 4PZE-A nrPDB 30 1.4 3ZH3-A nrPDB 30 1.5 4DNX-A nrPDB 30 1.5 6ACF-A nrPDB 30 1.6 3H9U-A nrPDB 30 1.6 4AEC-A nrPDB 30 1.6 5F8E-A nrPDB 30 1.6 3G1U-A nrPDB 30 1.6 3N58-A nrPDB 30 1.7 2ILV-A nrPDB 30 1.7 4S1V-D nrPDB 30 1.8 3K2C-A nrPDB 30 1.8 4K2X-A nrPDB 30 1.8 3OH0-A nrPDB 30 2.0 6DEB-A nrPDB 30 2.0 5NC8-A nrPDB 30 2.1 3TQD-A nrPDB 30 2.1 2EFY-A nrPDB 30 2.1 1F14-A nrPDB 30 2.1 2B4Q-A nrPDB 30 2.2 1JWB-B nrPDB 30 2.2 5JXW-A nrPDB 30 2.2 5TSD-A nrPDB 30 2.3 1B26-A nrPDB 30 2.4 4PRK-A nrPDB 29 2.5 3HDH-A nrPDB 29 2.6 3OND-A nrPDB 29 2.6 5FUB-A nrPDB 29 2.7 1BW9-B nrPDB 29 2.7 6DLL-A nrPDB 29 2.8 1LQU-A nrPDB 29 2.9 6HNS-A nrPDB 29 3.0 5DSE-A nrPDB 29 3.0 2YQ5-A nrPDB 29 3.0 4E6P-A nrPDB 29 3.0 1QO8-A nrPDB 29 3.1 3VZS-A nrPDB 29 3.3 3FBT-A nrPDB 29 3.3 3F9I-A nrPDB 29 3.4 4G2N-A nrPDB 29 3.5 4BOY-A nrPDB 29 3.8 4X28-D nrPDB 29 3.8 4CQM-B nrPDB 29 3.9 5M6D-A nrPDB 29 4.1 3BA1-A nrPDB 29 4.1 6C2H-A nrPDB 28 4.5 6F73-A nrPDB 28 4.7 5ITV-A nrPDB 28 5.1 6JDK-A nrPDB 28 5.5 4LMA-A nrPDB 28 5.5 2WUG-A nrPDB 28 5.5 1YQG-A nrPDB 28 5.5 6MVR-A nrPDB 28 5.8 3GBX-A nrPDB 28 5.8 1LTH-T nrPDB 28 5.9 5TX7-A nrPDB 28 6.1 3K8D-A nrPDB 28 6.1 2ISQ-A nrPDB 28 6.2 5TEN-A nrPDB 28 6.4 3U5T-A nrPDB 28 6.4 4LMB-A nrPDB 28 6.8 3X43-A nrPDB 28 6.9 1LU9-A nrPDB 28 7.2 1V47-A nrPDB 28 7.7 4NPH-A nrPDB 28 8.3 4ZV2-A nrPDB 28 8.4 5ZBK-A nrPDB 27 9.9 >2CF5-A nrPDB Length = 357 Score = 466 bits (1198), Expect = e-131, Method: Composition-based stats. Identities = 357/357 (100%), Positives = 357/357 (100%) Query: 1 MGIMEAERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGM 60 MGIMEAERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGM Sbjct: 1 MGIMEAERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGM 60 Query: 61 SNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWS 120 SNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWS Sbjct: 61 SNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWS 120 Query: 121 YNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQP 180 YNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQP Sbjct: 121 YNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQP 180 Query: 181 GLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSE 240 GLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSE Sbjct: 181 GLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSE 240 Query: 241 LADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFI 300 LADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFI Sbjct: 241 LADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFI 300 Query: 301 GSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGSNLDA 357 GSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGSNLDA Sbjct: 301 GSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGSNLDA 357 >1YQX-A nrPDB Length = 366 Score = 401 bits (1030), Expect = e-112, Method: Composition-based stats. Identities = 186/350 (53%), Positives = 243/350 (69%) Query: 4 MEAERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNY 63 E K GWAARD SG LSP+ ++ R TG EDV +++ CG+CH+DLH KND G S Y Sbjct: 11 EEHPVKAFGWAARDQSGHLSPFNFSRRATGEEDVRFKVLYCGVCHSDLHSIKNDWGFSMY 70 Query: 64 PMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYND 123 P+VPGHE+VGEV EVGS V K VGD VGVGCLVG C C C DLE YCPK I +Y Sbjct: 71 PLVPGHEIVGEVTEVGSKVKKVNVGDKVGVGCLVGACHSCESCANDLENYCPKMILTYAS 130 Query: 124 VYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLR 183 +Y +G T GG++ V +++++++ P+ M ++ APLLCAG+TVYSPL +FGL +PG Sbjct: 131 IYHDGTITYGGYSNHMVANERYIIRFPDNMPLDGGAPLLCAGITVYSPLKYFGLDEPGKH 190 Query: 184 GGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELAD 243 GI+GLGG+GH+ VK AKA G VTVIS+S K+EEAL++ GAD +++ DQ +M A Sbjct: 191 IGIVGLGGLGHVAVKFAKAFGSKVTVISTSPSKKEEALKNFGADSFLVSRDQEQMQAAAG 250 Query: 244 SLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSM 303 +LD +IDTV H L P LLK GKLIL+G PL+ L+ GRK++ GS IG M Sbjct: 251 TLDGIIDTVSAVHPLLPLFGLLKSHGKLILVGAPEKPLELPAFSLIAGRKIVAGSGIGGM 310 Query: 304 KETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGS 353 KET+EM++F + +++ IEV+ DY+NTA ERL KNDVRYRFV+DV + Sbjct: 311 KETQEMIDFAAKHNITADIEVISTDYLNTAMERLAKNDVRYRFVIDVGNT 360 >5Z0C-A nrPDB Length = 374 Score = 396 bits (1018), Expect = e-111, Method: Composition-based stats. Identities = 177/356 (49%), Positives = 247/356 (69%) Query: 2 GIMEAERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMS 61 G E K GWAARDPSG LSP+T++ R TG DV +++ CGICH+DLH KN+ + Sbjct: 6 GTEEHTVKAVGWAARDPSGHLSPFTFSRRATGELDVTFKVLYCGICHSDLHYIKNEWSNT 65 Query: 62 NYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSY 121 YP +PGHE+VGEV EVGS V+KF VGD VGVGC+VG C C C LE YCP +I ++ Sbjct: 66 IYPALPGHEIVGEVTEVGSKVNKFKVGDKVGVGCIVGSCHSCPNCNNHLENYCPNRILTF 125 Query: 122 NDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPG 181 Y +G GG++ VV + F V+IP+ + ++ AAPLLCAG+TVYSPL ++GL +PG Sbjct: 126 GSRYYDGTLNHGGYSDLMVVQEHFAVRIPDALPLDSAAPLLCAGITVYSPLRYYGLDKPG 185 Query: 182 LRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL 241 L G++GLGG+GHM VK AKA G VTV+S+S K+E+A+ LGA +++ +D +M Sbjct: 186 LHVGVVGLGGLGHMAVKFAKAFGVKVTVVSTSPAKKEDAISGLGAHSFILSTDAEQMQAA 245 Query: 242 ADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIG 301 ++D +IDTV H L P +SLLK GKL+++G PL+ L+LGRK++ GS IG Sbjct: 246 VGTMDGIIDTVSASHPLPPLISLLKSHGKLVMVGDPPKPLELPVFPLLLGRKMVAGSAIG 305 Query: 302 SMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGSNLDA 357 MKET+EM++F ++G+ + +EV+ MDYVNTA +R+ K+DV+YRFV+D+ + D+ Sbjct: 306 GMKETQEMIDFAAKEGVRADVEVIPMDYVNTAMQRVSKSDVKYRFVIDIGNTFNDS 361 >5VKT-A nrPDB Length = 362 Score = 357 bits (917), Expect = 4e-99, Method: Composition-based stats. Identities = 183/356 (51%), Positives = 244/356 (68%), Gaps = 3/356 (0%) Query: 4 MEAERKTT-GWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSN 62 ME KT GWAARD SG LSPY+++ R G DV I+++ CGICHTDLH KN+ G + Sbjct: 3 MEQGCKTAHGWAARDASGHLSPYSFSARIQGDADVTIKVLFCGICHTDLHVIKNEWGNAM 62 Query: 63 YPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYN 122 YP+VPGHEVVG V +VG V+KF GD VGVG V C C C E YCP + + N Sbjct: 63 YPVVPGHEVVGVVTDVGHGVTKFKAGDTVGVGYFVDSCRTCESCSTGHENYCPDLVLTSN 122 Query: 123 --DVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQP 180 D + +G T+GGF+ VV Q FVV++PE + ++ AAPLLCAGVTVYSP++ + L +P Sbjct: 123 GVDHHHHGATTKGGFSDVLVVSQDFVVRVPESLPLDGAAPLLCAGVTVYSPMAQYALNEP 182 Query: 181 GLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSE 240 G G++GLGG+GHM VK AKA G VTVISSS KR+EAL LGAD +++ D A+M Sbjct: 183 GKHLGVVGLGGLGHMAVKFAKAFGMTVTVISSSPGKRDEALGRLGADAFLVSHDAAQMKA 242 Query: 241 LADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFI 300 A +LD +IDTV H + P L+LLK G+++++G + PL+ ++ G K + G+ + Sbjct: 243 AAATLDGIIDTVSAGHQIVPLLALLKPMGQMVVVGAPSTPLELPAYAIITGGKRVAGNGV 302 Query: 301 GSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGSNLD 356 GS+ + + ML+F E G+++ IEVV+MDYVNTA ERLEKNDVRYRFV+DV GS ++ Sbjct: 303 GSVADCQAMLDFAGEHGVTADIEVVQMDYVNTAIERLEKNDVRYRFVIDVAGSKME 358 >5FI5-A nrPDB Length = 357 Score = 355 bits (910), Expect = 3e-98, Method: Composition-based stats. Identities = 157/346 (45%), Positives = 225/346 (65%), Gaps = 8/346 (2%) Query: 8 RKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVP 67 K G AA+D SG+ SP+ ++ R TG DV ++++ CG C D +KN G ++YP V Sbjct: 16 VKAFGLAAKDSSGLFSPFNFSRRATGEHDVQLKVLYCGTCQYDREMSKNKFGFTSYPYVL 75 Query: 68 GHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYIN 127 GHE+VGEV EVGS V KF VGD VGV ++ CG C C ++E YCP+ ++ Sbjct: 76 GHEIVGEVTEVGSKVQKFKVGDKVGVASIIETCGKCEMCTNEVENYCPEAGSIDSN---- 131 Query: 128 GQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGIL 187 G + V+++ FV++ PE + ++ PLLCAG+T YSP+ +GL +PG R GI Sbjct: 132 ----YGACSNIAVINENFVIRWPENLPLDSGVPLLCAGITAYSPMKRYGLDKPGKRIGIA 187 Query: 188 GLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDY 247 GLGG+GH+ ++ AKA G VTVISSS KK+ EA + GAD +++ S+ +M A +LD Sbjct: 188 GLGGLGHVALRFAKAFGAKVTVISSSLKKKREAFEKFGADSFLVSSNPEEMQGAAGTLDG 247 Query: 248 VIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETE 307 +IDT+P +H+LEP L+LLK GKLI++G P + P L++G KV+ S GSMKE + Sbjct: 248 IIDTIPGNHSLEPLLALLKPLGKLIILGAPEMPFEVPAPSLLMGGKVMAASTAGSMKEIQ 307 Query: 308 EMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGS 353 EM+EF E + + +EV+ +DYVNTA ERL+ +DVRYRFV+D+ + Sbjct: 308 EMIEFAAEHNIVADVEVISIDYVNTAMERLDNSDVRYRFVIDIGNT 353 >5H82-A nrPDB Length = 389 Score = 352 bits (902), Expect = 2e-97, Method: Composition-based stats. Identities = 150/363 (41%), Positives = 219/363 (60%), Gaps = 13/363 (3%) Query: 8 RKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVP 67 + GWAA+D SG+LSP+ + R TG DV +++ CG+C D+ TKN G + YP VP Sbjct: 27 VEAYGWAAKDTSGLLSPFKFLRRTTGEHDVQFKVLYCGLCDWDVITTKNTYGTTKYPFVP 86 Query: 68 GHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWS------- 120 GHE++G V E+G+ V KF VGD VGVG +G CG C C LE YCPK I++ Sbjct: 87 GHEIMGIVTEIGNKVKKFKVGDKVGVGNFIGSCGKCERCNEGLEPYCPKVIYTDGTAFSD 146 Query: 121 -----YNDVYINGQPT-QGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSH 174 Y DV +G+ GG++ V ++ V + PE + + P+LC G+ YSP+ H Sbjct: 147 ENNTVYGDVSGDGEDRIYGGYSNIMVANEYVVFRWPENLPLAAGVPILCGGIVPYSPMRH 206 Query: 175 FGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSD 234 FGL +PGL G++G G +G + VK AKA G +VTVIS+S K++EA++ G D ++I + Sbjct: 207 FGLDKPGLSIGVVGFGRIGKLAVKFAKAFGANVTVISTSISKKQEAIEKYGVDRFLISKE 266 Query: 235 QAKMSELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKV 294 +M +LD + D VP H L P L+LLK +G +++GV + L++GR+ Sbjct: 267 PEEMKAAESTLDGIFDCVPSVHPLHPLLNLLKFEGTFVMLGVAVEAYELPVSPLLMGRRK 326 Query: 295 ITGSFIGSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGSN 354 GS G+MKET+EML+F + + S IE++ MDYVNTA ER+ K + + FV+D+E + Sbjct: 327 FVGSISGTMKETQEMLDFAAKHNIVSDIELIPMDYVNTALERIAKGNHKDAFVIDIENTL 386 Query: 355 LDA 357 A Sbjct: 387 KSA 389 >5H83-A nrPDB Length = 360 Score = 348 bits (893), Expect = 2e-96, Method: Composition-based stats. Identities = 158/346 (45%), Positives = 222/346 (64%), Gaps = 4/346 (1%) Query: 8 RKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVP 67 KT G+AA+D SG SP+ ++ R TG DV +++ CG C+ DL + N GM+ YP V Sbjct: 13 VKTFGFAAKDSSGFFSPFNFSRRATGENDVQFKVLYCGTCNYDLEMSTNKFGMTKYPFVI 72 Query: 68 GHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYIN 127 GHE+VG V E+GS V KF VGD VGVG VG C C C +E C K + N Sbjct: 73 GHEIVGVVTEIGSKVQKFKVGDKVGVGGFVGACEKCEMCVNGVENNCSKVESTDGHFGNN 132 Query: 128 GQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGIL 187 GG VV++K+ V PE + + PLLCAG+T YSPL +GL +PGL GI Sbjct: 133 ----FGGCCNIMVVNEKYAVVWPENLPLHSGVPLLCAGITTYSPLRRYGLDKPGLNIGIA 188 Query: 188 GLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDY 247 GLGG+GH+ ++ AKA G VT+ISSS KK+ EAL+ G D +++ S+ +M +LD Sbjct: 189 GLGGLGHLAIRFAKAFGAKVTLISSSVKKKREALEKFGVDSFLLNSNPEEMQGAYGTLDG 248 Query: 248 VIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETE 307 +IDT+PV H++ P+L+LLK GKLI++GV P + P L++G K+I GS GSMKET+ Sbjct: 249 IIDTMPVAHSIVPFLALLKPLGKLIILGVPEEPFEVPAPALLMGGKLIAGSAAGSMKETQ 308 Query: 308 EMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGS 353 EM++F + + + +EV+ +DY+NTA ER++ +DV+YRFV+DV + Sbjct: 309 EMIDFAAKHNIVADVEVIPIDYLNTAMERIKNSDVKYRFVIDVGNT 354 >3MEQ-A nrPDB Length = 365 Score = 348 bits (892), Expect = 3e-96, Method: Composition-based stats. Identities = 105/364 (28%), Positives = 167/364 (45%), Gaps = 23/364 (6%) Query: 1 MGIMEAERKTTGWAARDPS--------GILSPYTYTLRETGPEDVNIRIICCGICHTDLH 52 MG +EA+ + G A+ L+ + + GP + + I G+CHTDLH Sbjct: 9 MGTLEAQTQGPGSMAKTMKAAVVRAFGKPLTIDEVPIPQPGPGQIQVAIQASGVCHTDLH 68 Query: 53 QTKNDLGM-SNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLE 111 + D + N P +PGHE VG V VGS V GD VG+ L CG C C E Sbjct: 69 AAEGDWPVKPNPPFIPGHEGVGFVSAVGSGVKHVKEGDRVGIPWLYTACGHCRHCLGGWE 128 Query: 112 QYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSP 171 C +++ + G GGFA+ V FV +P+ + + AP+LCAGVTVY Sbjct: 129 TLCEEQLNT-------GYSVNGGFAEYVVADPNFVGHLPKNIDFNEIAPVLCAGVTVYKG 181 Query: 172 LSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVI 231 L +PG I G+GG+GHM V+ A+AMG +V + ++ + + LGA V Sbjct: 182 LKVT-DTKPGDWVVISGIGGLGHMAVQYARAMGLNV-AAVDIDDRKLDLARRLGATVTVN 239 Query: 232 GSDQAK-----MSELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTP 286 A E V+ T A E L ++ G + L G+ Sbjct: 240 AKTVADPAAYIRKETDGGAQGVLVTAVSPKAFEQALGMVARGGTVSLNGLPPGDFPLSIF 299 Query: 287 LLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRF 346 ++L + GS +G+ + +E L+F + + + I+ K++ +N F+ + + ++ R Sbjct: 300 NMVLNGVTVRGSIVGTRLDLQESLDFAADGKVKATIQTGKLEDINAIFDDMRQGNIEGRI 359 Query: 347 VVDV 350 V+D+ Sbjct: 360 VMDL 363 >3PII-A nrPDB Length = 339 Score = 347 bits (890), Expect = 5e-96, Method: Composition-based stats. Identities = 108/337 (32%), Positives = 161/337 (47%), Gaps = 13/337 (3%) Query: 19 SGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGM-SNYPMVPGHEVVGEVVE 77 L +V +RI CG+CHTDLH D + P++PGHE VG V E Sbjct: 10 KEPLKIKEVEKPTISYGEVLVRIKACGVCHTDLHAAHGDWPVKPKLPLIPGHEGVGIVEE 69 Query: 78 VGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAK 137 VG V+ VGD VG+ L CG C C E C + G GG+A+ Sbjct: 70 VGPGVTHLKVGDRVGIPWLYSACGHCDYCLSGQETLCEHQ-------KNAGYSVDGGYAE 122 Query: 138 ATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGV 197 +VVKIP+ ++ E+AAP+ CAGVT Y L G +PG I G+GG GH+ V Sbjct: 123 YCRAAADYVVKIPDNLSFEEAAPIFCAGVTTYKALKVTG-AKPGEWVAIYGIGGFGHVAV 181 Query: 198 KIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAK---MSELADSLDYVIDTVPV 254 + AKAMG +V V ++ E ++LGAD V + M E + + T Sbjct: 182 QYAKAMGLNV-VAVDIGDEKLELAKELGADLVVNPLKEDAAKFMKEKVGGVHAAVVTAVS 240 Query: 255 HHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCK 314 A + + ++ G +L+G+ + +L I GS +G+ K+ +E L+F Sbjct: 241 KPAFQSAYNSIRRGGACVLVGLPPEEMPIPIFDTVLNGIKIIGSIVGTRKDLQEALQFAA 300 Query: 315 EKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVE 351 E + +IIEV ++ +N F+R+ K + R V+ +E Sbjct: 301 EGKVKTIIEVQPLEKINEVFDRMLKGQINGRVVLTLE 337 >3TWO-A nrPDB Length = 348 Score = 335 bits (858), Expect = 3e-92, Method: Composition-based stats. Identities = 124/352 (35%), Positives = 201/352 (57%), Gaps = 12/352 (3%) Query: 8 RKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVP 67 ++ G+A P+ ++ GP DV I I+ GICH+D+H ++ YPM+P Sbjct: 3 VQSKGFAIFSKDEHFKPHDFSRHAVGPRDVLIDILYAGICHSDIHSAYSEWKEGIYPMIP 62 Query: 68 GHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYN--DVY 125 GHE+ G + EVG V KF +GD+VGVGC V C C PC+ EQ+C K +++Y+ D + Sbjct: 63 GHEIAGIIKEVGKGVKKFKIGDVVGVGCFVNSCKACKPCKEHQEQFCTKVVFTYDCLDSF 122 Query: 126 INGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGG 185 + +P GG++ VV + +V+ + + +E+ APLLCAG+T YSPL F G + G Sbjct: 123 HDNEPHMGGYSNNIVVDENYVISVDKNAPLEKVAPLLCAGITTYSPLK-FSKVTKGTKVG 181 Query: 186 ILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSL 245 + G GG+G M VK A AMG V+V + + K+++AL +G + Q K L Sbjct: 182 VAGFGGLGSMAVKYAVAMGAEVSVFARNEHKKQDAL-SMGVKHFYTDPKQCKEE-----L 235 Query: 246 DYVIDTVPVHHALEPYLSLLKLDGKLILMGVIN---NPLQFLTPLLMLGRKVITGSFIGS 302 D++I T+P H+ L+ YL LL +G L L+G+ P+ + + LG + + GS IG Sbjct: 236 DFIISTIPTHYDLKDYLKLLTYNGDLALVGLPPVEVAPVLSVFDFIHLGNRKVYGSLIGG 295 Query: 303 MKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGSN 354 +KET+EM++F + + I+++ ++TA+ L ++R+V+D++ S Sbjct: 296 IKETQEMVDFSIKHNIYPEIDLILGKDIDTAYHNLTHGKAKFRYVIDMKKSF 347 >1UUF-A nrPDB Length = 369 Score = 332 bits (852), Expect = 1e-91, Method: Composition-based stats. Identities = 147/348 (42%), Positives = 212/348 (60%), Gaps = 5/348 (1%) Query: 5 EAERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYP 64 +A K A L P T RE GP DV I I CG+CH+DLHQ +++ + YP Sbjct: 18 KAGLKIKAVGAYSAKQPLEPMDITRREPGPNDVKIEIAYCGVCHSDLHQVRSEWAGTVYP 77 Query: 65 MVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDV 124 VPGHE+VG VV VG V K+ GD+VGVGC+V C C CE LE YC +YN Sbjct: 78 CVPGHEIVGRVVAVGDQVEKYAPGDLVGVGCIVDSCKHCEECEDGLENYCDHMTGTYNSP 137 Query: 125 YINGQPTQ-GGFAKATVVHQKFVVKIP-EGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGL 182 + GG+++ VVH+++V++I + APLLCAG+T YSPL H+ PG Sbjct: 138 TPDEPGHTLGGYSQQIVVHERYVLRIRHPQEQLAAVAPLLCAGITTYSPLRHW-QAGPGK 196 Query: 183 RGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELA 242 + G++G+GG+GHMG+K+A AMG HV ++S KR EA + LGAD+ V + +M+ Sbjct: 197 KVGVVGIGGLGHMGIKLAHAMGAHVVAFTTSEAKR-EAAKALGADEVVNSRNADEMAAHL 255 Query: 243 DSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPL-LMLGRKVITGSFIG 301 S D++++TV H L+ + +LLK DG + L+G P + L++ R+ I GS IG Sbjct: 256 KSFDFILNTVAAPHNLDDFTTLLKRDGTMTLVGAPATPHKSPEVFNLIMKRRAIAGSMIG 315 Query: 302 SMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVD 349 + ET+EML+FC E G+ + IE+++ D +N A+ER+ + DV+YRFV+D Sbjct: 316 GIPETQEMLDFCAEHGIVADIEMIRADQINEAYERMLRGDVKYRFVID 363 >6N7L-A nrPDB Length = 353 Score = 332 bits (852), Expect = 1e-91, Method: Composition-based stats. Identities = 102/341 (29%), Positives = 158/341 (46%), Gaps = 14/341 (4%) Query: 19 SGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGM-SNYPMVPGHEVVGEVVE 77 L +RE G +V ++++ CG+CHTDLH D P++PGHE VG VV Sbjct: 23 GEPLKIQEVPVREPGRYEVLVKVMACGVCHTDLHAVDGDWPAKPKMPLIPGHEGVGIVVA 82 Query: 78 VGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAK 137 G D GD VGV L CG C C E C + G GGFA+ Sbjct: 83 CGPDA-MVKEGDAVGVPWLYSACGCCDYCITGWETLCEAQQNG-------GYSVDGGFAE 134 Query: 138 ATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGV 197 + ++V + + + AP+LCAGVTVY L +PG I G+GG+GH+ V Sbjct: 135 YVIADSRYVGHLKSNVNFLEIAPILCAGVTVYKGLKETE-TKPGEWVAISGIGGLGHVAV 193 Query: 198 KIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAK---MSELADSLDYVIDTVPV 254 + AKAMG HV I + E + LGAD V + + + + T Sbjct: 194 QYAKAMGMHVAAI-DVADDKLELAKKLGADLTVNAKTTDPGTYLHKEVGGMHGALITAVS 252 Query: 255 HHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCK 314 A + + +L+ G + L G+ + +L R + GS +G+ K+ +E L+F Sbjct: 253 PIAFKQGIDVLRRKGTIALNGLPPGSFELPIFETVLKRITVRGSIVGTRKDLQEALDFAN 312 Query: 315 EKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEGSNL 355 E + + + K++ +N F++++K + R V+D+ GS Sbjct: 313 EGLVKATVTSAKLEDINDVFDKMKKGQIDGRIVLDIAGSQN 353 >1LLU-A nrPDB Length = 342 Score = 329 bits (843), Expect = 1e-90, Method: Composition-based stats. Identities = 95/336 (28%), Positives = 154/336 (45%), Gaps = 13/336 (3%) Query: 19 SGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGM-SNYPMVPGHEVVGEVVE 77 L + GP V ++I G+CHTDLH + D + P +PGHE VG V Sbjct: 16 GAPLRIEEVKVPLPGPGQVLVKIEASGVCHTDLHAAEGDWPVKPPLPFIPGHEGVGYVAA 75 Query: 78 VGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAK 137 VGS V++ GD VG+ L CG C C E C + + G GG+A+ Sbjct: 76 VGSGVTRVKEGDRVGIPWLYTACGCCEHCLTGWETLCESQQNT-------GYSVNGGYAE 128 Query: 138 ATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGV 197 + +V +P+ + + AP+LCAGVTVY L +PG I G+GG+GH+ V Sbjct: 129 YVLADPNYVGILPKNVEFAEIAPILCAGVTVYKGLKQTN-ARPGQWVAISGIGGLGHVAV 187 Query: 198 KIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELA---DSLDYVIDTVPV 254 + A+AMG HV I + + E + LGA V + + + V+ T Sbjct: 188 QYARAMGLHVAAI-DIDDAKLELARKLGASLTVNARQEDPVEAIQRDIGGAHGVLVTAVS 246 Query: 255 HHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCK 314 + A + + + G + L+G+ ++L I GS +G+ + +E L+F Sbjct: 247 NSAFGQAIGMARRGGTIALVGLPPGDFPTPIFDVVLKGLHIAGSIVGTRADLQEALDFAG 306 Query: 315 EKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDV 350 E + + I K+D +N +++ + R V+++ Sbjct: 307 EGLVKATIHPGKLDDINQILDQMRAGQIEGRIVLEM 342 >4Z6K-A nrPDB Length = 346 Score = 323 bits (827), Expect = 9e-89, Method: Composition-based stats. Identities = 92/332 (27%), Positives = 147/332 (44%), Gaps = 13/332 (3%) Query: 22 LSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSN-YPMVPGHEVVGEVVEVGS 80 L + G ++ +++ G+CHTDLH + D + P +PGHE VG + VG Sbjct: 13 LQIEEVDIPTPGAGEIVVKMQASGVCHTDLHAVEGDWPVKPSPPFIPGHEGVGLITAVGE 72 Query: 81 DVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATV 140 V+ GD VGV L CG C+ C E C + +G G FA+ + Sbjct: 73 GVTHVKEGDRVGVAWLYSACGHCTHCLGGWETLCESQ-------QNSGYSVNGSFAEYVL 125 Query: 141 VHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIA 200 + +V IPE + + AP+LCAGVTVY L +PG I G+GG+GHM V+ A Sbjct: 126 ANANYVGIIPESVDSIEIAPVLCAGVTVYKGLKMT-DTKPGDWVVISGIGGLGHMAVQYA 184 Query: 201 KAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAK---MSELADSLDYVIDTVPVHHA 257 AMG +V + + + LGA V + + + + T A Sbjct: 185 IAMGLNV-AAVDIDDDKLAFAKKLGAKVTVNAKNTDPAEYLQKEIGGAHGALVTAVSAKA 243 Query: 258 LEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKG 317 + LS+L+ G L+ G+ +L I GS +G+ + +E L+ Sbjct: 244 FDQALSMLRRGGTLVCNGLPPGDFPVSIFDTVLNGITIRGSIVGTRLDLQESLDMAAAGK 303 Query: 318 LSSIIEVVKMDYVNTAFERLEKNDVRYRFVVD 349 + + + ++ +N FER+ + + R V+D Sbjct: 304 VKATVTAEPLENINDIFERMRQGKIEGRIVID 335 >3S2F-A nrPDB Length = 340 Score = 320 bits (820), Expect = 6e-88, Method: Composition-based stats. Identities = 99/335 (29%), Positives = 151/335 (45%), Gaps = 13/335 (3%) Query: 19 SGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSN-YPMVPGHEVVGEVVE 77 L+ + + GP V ++I G+CHTDLH D + P +PGHE VG V Sbjct: 12 GAPLTIDEVPVPQPGPGQVQVKIEASGVCHTDLHAADGDWPVKPTLPFIPGHEGVGYVSA 71 Query: 78 VGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAK 137 VGS VS+ GD VGV L CG C C + E C K+ + G GG+ + Sbjct: 72 VGSGVSRVKEGDRVGVPWLYSACGYCEHCLQGWETLCEKQQNT-------GYSVNGGYGE 124 Query: 138 ATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGV 197 V +V +P+ + + AP+LCAGVTVY L +PG I G+GG+GH+ V Sbjct: 125 YVVADPNYVGLLPDKVGFVEIAPILCAGVTVYKGLKVT-DTRPGQWVVISGIGGLGHVAV 183 Query: 198 KIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAK---MSELADSLDYVIDTVPV 254 + A+AMG + + + LGA+ V D + + V+ T Sbjct: 184 QYARAMGL-RVAAVDIDDAKLNLARRLGAEVAVNARDTDPAAWLQKEIGGAHGVLVTAVS 242 Query: 255 HHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCK 314 A + +++ G + L G+ ++L I GS +G+ + +E L+F Sbjct: 243 PKAFSQAIGMVRRGGTIALNGLPPGDFGTPIFDVVLKGITIRGSIVGTRSDLQESLDFAA 302 Query: 315 EKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVD 349 + + + K+D VN F RL + V R V+D Sbjct: 303 HGDVKATVSTAKLDDVNDVFGRLREGKVEGRVVLD 337 >1HSZ-A nrPDB Length = 374 Score = 305 bits (780), Expect = 3e-83, Method: Composition-based stats. Identities = 83/369 (22%), Positives = 138/369 (37%), Gaps = 34/369 (9%) Query: 8 RKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVP 67 + W + P S + +V I+++ GIC TD H +L ++ P++ Sbjct: 10 KAAVLWEVKKP---FSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNL-VTPLPVIL 65 Query: 68 GHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWS------- 120 GHE G V VG V+ GD V + CG C C+ YC K Sbjct: 66 GHEAAGIVESVGEGVTTVKPGDKV-IPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQ 124 Query: 121 --YNDVYINGQPTQ-----GGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLS 173 G+P F++ TVV + V KI +E+ + C T Y Sbjct: 125 DGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAV 184 Query: 174 HFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGS 233 + PG + GLGGVG V KA G + NK + ++LGA + + Sbjct: 185 NVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQ 244 Query: 234 D-----QAKMSELAD-SLDYVIDTVP-VHHALEPYLSLLKLDGKLILMGVINNPLQF-LT 285 D Q + E+ D +D+ + + + + L + G +++GV + Sbjct: 245 DYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSIN 304 Query: 286 PLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSSI------IEVVKMDYVNTAFERLEK 339 P+L+L + G+ G K E + + + V+ + +N F+ L Sbjct: 305 PMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHS 364 Query: 340 NDVRYRFVV 348 R V+ Sbjct: 365 GKSI-RTVL 372 >1U3W-A nrPDB Length = 374 Score = 303 bits (777), Expect = 5e-83, Method: Composition-based stats. Identities = 85/369 (23%), Positives = 144/369 (39%), Gaps = 34/369 (9%) Query: 8 RKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVP 67 + W + P S + +V I+++ GIC +D H +L ++ P++ Sbjct: 10 KAAVLWELKKP---FSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNL-VTPLPVIL 65 Query: 68 GHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWS------- 120 GHE G V VG V+ GD V + CG C C+ YC K Sbjct: 66 GHEAAGIVESVGEGVTTVKPGDKV-IPLFTPQCGKCRICKNPESNYCLKNDLGNPRGTLQ 124 Query: 121 --YNDVYINGQPTQ-----GGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLS 173 +G+P F++ TVV + V KI +E+ + C T Y Sbjct: 125 DGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAV 184 Query: 174 HFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGS 233 PG + GLGGVG V KA G + NK + ++LGA + + Sbjct: 185 KVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQ 244 Query: 234 D-----QAKMSELAD-SLDYVIDTVP-VHHALEPYLSLLKLDGKLILMGVINNPLQF-LT 285 D Q + E+ D +D+ + + + + L + G +++GV + + Sbjct: 245 DYKKPIQEVLKEMTDGGVDFSFEVIGQLDTMMASLLCCHEACGTSVIVGVPPDSQNLSIN 304 Query: 286 PLLMLGRKVITGSFIGSMKETEEMLEF-----CKEKGLSSII-EVVKMDYVNTAFERLEK 339 P+L+L + G+ G K E + + K+ L ++I V+ + +N F+ L Sbjct: 305 PMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNVLPFEKINEGFDLLRS 364 Query: 340 NDVRYRFVV 348 R V+ Sbjct: 365 GKSI-RTVL 372 >1HSO-A nrPDB Length = 374 Score = 303 bits (777), Expect = 7e-83, Method: Composition-based stats. Identities = 81/362 (22%), Positives = 142/362 (39%), Gaps = 33/362 (9%) Query: 8 RKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVP 67 + W + P S + +V I+++ GIC TD H + ++ P++ Sbjct: 10 KAAVLWELKKP---FSIEEVEVAPPKAHEVRIKMVAVGICGTDDHVVSGTM-VTPLPVIL 65 Query: 68 GHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIW-------- 119 GHE G V VG V+ GD V + + CG C C+ YC K Sbjct: 66 GHEAAGIVESVGEGVTTVKPGDKV-IPLAIPQCGKCRICKNPESNYCLKNDVSNPQGTLQ 124 Query: 120 -SYNDVYINGQPTQ-----GGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLS 173 + +P F++ TVV + V KI +E+ + C T Y Sbjct: 125 DGTSRFTCRRKPIHHFLGISTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAV 184 Query: 174 HFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGS 233 + PG + GLGGVG + KA G + NK + ++LGA + + Sbjct: 185 NVAKVTPGSTCAVFGLGGVGLSAIMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQ 244 Query: 234 D-----QAKMSELAD-SLDYVIDTVP-VHHALEPYLSLLKLDGKLILMGVINNPLQF-LT 285 D Q + E+ D +D+ + + + + L + G +++GV + + Sbjct: 245 DYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQNLSMN 304 Query: 286 PLLMLGRKVITGSFIGSMKETEEMLEF-----CKEKGLSSII-EVVKMDYVNTAFERLEK 339 P+L+L + G+ +G K E + + K+ L ++I V+ + +N F+ L Sbjct: 305 PMLLLTGRTWKGAILGGFKSKECVPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHS 364 Query: 340 ND 341 Sbjct: 365 GK 366 >4OAQ-A nrPDB Length = 367 Score = 300 bits (768), Expect = 7e-82, Method: Composition-based stats. Identities = 129/353 (36%), Positives = 195/353 (55%), Gaps = 14/353 (3%) Query: 9 KTTGWAARDPSGILSPY--TYTLRETGPEDVNIRIICCGICHTDLHQTKNDL-GMSNYPM 65 K G+A DP P +Y ++ P DV ++ CG+C++D+H + + Sbjct: 8 KFQGFAVSDPKNWNRPKLASYERKQINPHDVVLKNEVCGLCYSDIHTLSAGWQPLQRDNL 67 Query: 66 VPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYN--D 123 V GHE++GEV+ VG +V++F VGD VG+G C C C+ D EQYC + +YN D Sbjct: 68 VVGHEIIGEVIAVGDEVTEFKVGDRVGIGAASSSCRSCQRCDSDNEQYCKQGAATYNSKD 127 Query: 124 VYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPL-SHFGLKQPGL 182 V N TQGG++ ++ +KFV IPE + APL+CAG+TV+SPL + GL G Sbjct: 128 VRSNNYVTQGGYSSHSIADEKFVFAIPEDLPSSYGAPLMCAGITVFSPLIRNLGLDARGK 187 Query: 183 RGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYV-IGSDQAKMSEL 241 GI+G+GG+GH+ ++ A AMG +VT S S+ K+E+A++ LGA D+V G D+ Sbjct: 188 NVGIIGIGGLGHLALQFANAMGANVTAFSRSSSKKEQAMK-LGAHDFVATGEDKTWYKNY 246 Query: 242 ADSLDYVIDTVPVHH--ALEPYLSLLKLDGKLILMGVINNPLQF-LTPLLMLGRKVITG- 297 D D++++ L YLS LK+D K + +G+ + +F ++P L + G Sbjct: 247 DDHFDFILNCASGIDGLNLSEYLSTLKVDKKFVSVGLPPSEDKFEVSPFTFLQQGASFGS 306 Query: 298 SFIGSMKETEEMLEFCKEKGLSSIIEVVKMDYVN--TAFERLEKNDVRYRFVV 348 S +GS E +EML + + +IE V + N A +R DVRYRFV Sbjct: 307 SLLGSKTEVKEMLNLAAKHNVRPMIEEVPISEENCAKALDRCHAGDVRYRFVF 359 >4EEZ-A nrPDB Length = 348 Score = 300 bits (767), Expect = 9e-82, Method: Composition-based stats. Identities = 92/338 (27%), Positives = 152/338 (44%), Gaps = 14/338 (4%) Query: 17 DPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVV 76 +P G LR P + + + CG+CHTDLH D G + V GHE +G V Sbjct: 9 NPDGYADLVEKELRAIKPNEALLDMEYCGVCHTDLHVAAGDFG-NKAGTVLGHEGIGIVK 67 Query: 77 EVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFA 136 E+G+DVS VGD V V CG C C E +C +V G GG A Sbjct: 68 EIGADVSSLQVGDRVSVAWFFEGCGHCEYCVSGNETFC-------REVKNAGYSVDGGMA 120 Query: 137 KATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMG 196 + +V + VK+P+G+ +A+ + CAGVT Y + G +PG I G GG+G++ Sbjct: 121 EEAIVVADYAVKVPDGLDPIEASSITCAGVTTYKAIKVSG-VKPGDWQVIFGAGGLGNLA 179 Query: 197 VKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELAD-----SLDYVIDT 251 ++ AK + + N+ + + +GAD + D + E+ + I Sbjct: 180 IQYAKNVFGAKVIAVDINQDKLNLAKKIGADVTINSGDVNPVDEIKKITGGLGVQSAIVC 239 Query: 252 VPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLE 311 A E ++ LK GK++ + V N + P ++ + GS +G+ + E + Sbjct: 240 AVARIAFEQAVASLKPMGKMVAVAVPNTEMTLSVPTVVFDGVEVAGSLVGTRLDLAEAFQ 299 Query: 312 FCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVD 349 F E + I+ K++ +N + ++ + R V+D Sbjct: 300 FGAEGKVKPIVATRKLEEINDIIDEMKAGKIEGRMVID 337 >4DLA-A nrPDB Length = 396 Score = 296 bits (757), Expect = 1e-80, Method: Composition-based stats. Identities = 79/366 (21%), Positives = 142/366 (38%), Gaps = 33/366 (9%) Query: 15 ARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGE 74 A +P+ L + +V ++++ +CHTD + +P V GHE G Sbjct: 32 AWEPNKPLVIEDVQVAPPQAGEVRVKVLYTALCHTDAYTWSGKDPEGLFPCVLGHEAAGI 91 Query: 75 VVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSY----------NDV 124 V VG V++ GD V + C C C C+ C K + + Sbjct: 92 VESVGEGVTEVQPGDHV-IPCYQAECRECKFCKSGKTNLCGKVRAATGVGVMMNDRKSRF 150 Query: 125 YINGQPT-----QGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQ 179 ING+P F++ TVVH V KI +E+ L C T + + + Sbjct: 151 SINGKPIYHFMGTSTFSQYTVVHDVSVAKIDPVAPLEKVCLLGCGVPTGLGAVWNTAKVE 210 Query: 180 PGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMS 239 PG + GLG VG + AKA G + + K+ + ++ G +++ + + Sbjct: 211 PGSIVAVFGLGTVGLAVAEGAKAAGASRIIGIDIDSKKFDRAKNFGVTEFINPKEHEQPI 270 Query: 240 E------LADSLDYVIDTVPVHHALEPYLSLL-KLDGKLILMGVINNPLQFLT-PLLMLG 291 + +DY + + + L K G +++GV + + T P ++ Sbjct: 271 QQVIVDLTDGGVDYSFECIGNVSVMRSALECCHKGWGTSVIVGVAASGQEISTRPFQLVT 330 Query: 292 RKVITGSFIGSMKETEEMLEFCKEKGLSSIIEV-------VKMDYVNTAFERLEKNDVRY 344 +V G+ G K ++ + L I+V + + +N AF+ + D Sbjct: 331 GRVWKGTAFGGFKSRSQVPSLVDKY-LKKEIKVDEYITHNMTLADINKAFDLMHDGDCL- 388 Query: 345 RFVVDV 350 R V+D+ Sbjct: 389 RVVLDM 394 >3COS-A nrPDB Length = 381 Score = 291 bits (745), Expect = 3e-79, Method: Composition-based stats. Identities = 79/373 (21%), Positives = 128/373 (34%), Gaps = 33/373 (8%) Query: 1 MGIMEAERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGM 60 MG K A + L + +V I+II +CHTD + Sbjct: 2 MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEG 61 Query: 61 SNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPK---- 116 +P++ GHE G V +G V+ GD V + C C C L C K Sbjct: 62 LAFPVIVGHEAAGIVESIGPGVTNVKPGDKV-IPLYAPLCRKCKFCLSPLTNLCGKISNL 120 Query: 117 ---------KIWSYNDVYINGQPT-----QGGFAKATVVHQKFVVKIPEGMAVEQAAPLL 162 + G+P F++ TVV + KI + +E+ L Sbjct: 121 KSPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLG 180 Query: 163 CAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQ 222 C T Y + PG + GLGGVG V KA G + N ++ + Sbjct: 181 CGFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAK 240 Query: 223 DLGADDYVIGSD-----QAKMSELA-DSLDYVIDTVPVHHALEPYLSL-LKLDGKLILMG 275 LGA D + D Q + EL +D+ +D ++ L G +G Sbjct: 241 ALGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIG 300 Query: 276 VINNPLQF-LTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSSI------IEVVKMD 328 V + P ++ + I G+F G K + + + + + D Sbjct: 301 VAAGSKGLTVFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFD 360 Query: 329 YVNTAFERLEKND 341 ++ AF+ + + Sbjct: 361 KISEAFDLMNQGK 373 >1EE2-A nrPDB Length = 373 Score = 288 bits (736), Expect = 4e-78, Method: Composition-based stats. Identities = 78/360 (21%), Positives = 139/360 (38%), Gaps = 29/360 (8%) Query: 9 KTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPG 68 K + S + +V I+++ GIC +D H L ++ P++ G Sbjct: 8 KCKAAVLWEQKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDDHVVSGTL-VAPLPVIAG 66 Query: 69 HEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIW--------S 120 HE G V +G V+ GD V + + CG CS C+ C K + Sbjct: 67 HEAAGIVESIGEGVTTVRPGDKV-IPLFIPQCGKCSVCKHPEGNLCLKNLSMPRGTMQDG 125 Query: 121 YNDVYINGQPTQ-----GGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHF 175 + G+P F++ TVV + V KI +E+ + C T Y Sbjct: 126 TSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLVGCGFSTGYGSAVKV 185 Query: 176 GLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSD- 234 G + GLGGVG + KA G + NK + +++GA + V D Sbjct: 186 AKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATECVNPQDY 245 Query: 235 ----QAKMSELA-DSLDYVIDTVPVHHALEPYLSLL-KLDGKLILMGVINNPLQF-LTPL 287 Q ++E++ +D+ + + + LS + G +++GV + + P+ Sbjct: 246 KKPIQEVLTEMSNGGVDFSFEVIGRLDTMVAALSCCQEAYGVSVIVGVPPDSQNLSMNPM 305 Query: 288 LMLGRKVITGSFIGSMKETEEMLEF-----CKEKGLSSII-EVVKMDYVNTAFERLEKND 341 L+L + G+ G K + + + K+ L +I V+ + +N F+ L Sbjct: 306 LLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFDLLRSGK 365 >2EER-A nrPDB Length = 347 Score = 286 bits (733), Expect = 8e-78, Method: Composition-based stats. Identities = 89/345 (25%), Positives = 148/345 (42%), Gaps = 24/345 (6%) Query: 19 SGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLG--------MSNYPMVPGHE 70 L + + V I+I G+CH+D+H + G P+ GHE Sbjct: 10 GKPLKLEDIPIPKPKGSQVLIKIEAAGVCHSDVHMRQGRFGNLRIVEDLGVKLPVTLGHE 69 Query: 71 VVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQP 130 + G + EVG +V ++ GD+V V G G C C E C W G Sbjct: 70 IAGRIEEVGDEVVGYSKGDLVAVNPWEGE-GNCYYCRIGEEHLCDSPRW-------LGIN 121 Query: 131 TQGGFAKATVV-HQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGL 189 G +A+ +V H K++ K+ ++ +AAPL C+GVT Y + L I Sbjct: 122 YDGAYAEYVLVPHYKYLYKLRR-LSAVEAAPLTCSGVTTYRAVRKASLDPSKTLVVIGAG 180 Query: 190 GGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL-----ADS 244 GG+G M ++IAKA+ + ++ EA + GAD + S Q +SE+ Sbjct: 181 GGLGTMAIQIAKAVSGATIIGVDVREEALEAAKRAGADYVINASSQDPVSEIRRITQGKG 240 Query: 245 LDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMK 304 D VID L Y +L GK +++G+ L++ PL+ L GS +G+ Sbjct: 241 ADAVIDLNNSEKTLSIYPYVLAKQGKYVMVGLFGADLKYHAPLITLNEVQFIGSLVGNQS 300 Query: 305 ETEEMLEFCKEKGLSSII-EVVKMDYVNTAFERLEKNDVRYRFVV 348 + ++ + + ++ + +K++ N A + LE R V+ Sbjct: 301 DFLGIMSLAEAGKVKPMVTKTMKLEEANEAIDNLENFKAVGRQVL 345 >4JJI-A nrPDB Length = 378 Score = 286 bits (732), Expect = 1e-77, Method: Composition-based stats. Identities = 80/364 (21%), Positives = 139/364 (38%), Gaps = 31/364 (8%) Query: 15 ARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGE 74 A +P+ L + +V I+I+ +CHTD + +P + GHE G Sbjct: 14 AYEPNKPLVIEDVQVAPPQAGEVRIKILYTALCHTDAYTWSGKDPEGLFPCILGHEAAGI 73 Query: 75 VVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSY----------NDV 124 V VG V++ GD V + C C C C+ C K + + Sbjct: 74 VESVGEGVTEVQAGDHV-IPCYQAECRECKFCKSGKTNLCGKVRSATGVGIMMNDRKSRF 132 Query: 125 YINGQPT-----QGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQ 179 +NG+P F++ TVVH V KI +++ L C T + + + Sbjct: 133 SVNGKPIYHFMGTSTFSQYTVVHDVSVAKIDPTAPLDKVCLLGCGVPTGLGAVWNTAKVE 192 Query: 180 PGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMS 239 PG I GLG VG + AK G + + K+ E + G +++V D K Sbjct: 193 PGSNVAIFGLGTVGLAVAEGAKTAGASRIIGIDIDSKKYETAKKFGVNEFVNPKDHDKPI 252 Query: 240 E------LADSLDYVIDTVPVHHALEPYLSLL-KLDGKLILMGVINNPLQFLT-PLLMLG 291 + +DY + + + L K G +++GV + + T P ++ Sbjct: 253 QEVIVDLTDGGVDYSFECIGNVSVMRAALECCHKGWGTSVIVGVAASGQEISTRPFQLVT 312 Query: 292 RKVITGSFIGSMKETEEMLEFCKEK-----GLSSII-EVVKMDYVNTAFERLEKNDVRYR 345 +V G+ G K ++ ++ + I + + +N AF+ L + R Sbjct: 313 GRVWKGTAFGGFKSRTQVPWLVEKYMNKEIKVDEYITHNLTLGEINKAFDLLHEGTCL-R 371 Query: 346 FVVD 349 V+D Sbjct: 372 CVLD 375 >1MC5-A nrPDB Length = 374 Score = 283 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 85/371 (22%), Positives = 136/371 (36%), Gaps = 33/371 (8%) Query: 8 RKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVP 67 + W A P LS + +V I+II +CHTD + +P++ Sbjct: 9 KAAVAWEAGKP---LSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGCFPVIL 65 Query: 68 GHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPK---------KI 118 GHE G V VG V+K GD V + + CG C C C K Sbjct: 66 GHEGAGIVESVGEGVTKLKAGDTV-IPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMP 124 Query: 119 WSYNDVYINGQPT-----QGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLS 173 + G+ F++ TVV V KI +++ L C T Y Sbjct: 125 DGTSRFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAV 184 Query: 174 HFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGS 233 + +PG + GLGGVG + K G + NK + ++ GA + + Sbjct: 185 NTAKLEPGSVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATECINPQ 244 Query: 234 D-----QAKMSELAD-SLDYVIDTVPVHHALEPYLS-LLKLDGKLILMGVINNPLQFLT- 285 D Q + E+ D +DY + + + L K G +++GV + + T Sbjct: 245 DFSKPIQEVLIEMTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATR 304 Query: 286 PLLMLGRKVITGSFIGSMKETEEMLEFCKE---KGLSSI---IEVVKMDYVNTAFERLEK 339 P ++ + G+ G K E + + E K + + D +N AFE + Sbjct: 305 PFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFELMHS 364 Query: 340 NDVRYRFVVDV 350 R VV + Sbjct: 365 GKSI-RTVVKI 374 >5ENV-A nrPDB Length = 347 Score = 283 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 94/341 (27%), Positives = 152/341 (44%), Gaps = 17/341 (4%) Query: 17 DPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMS-NYPMVPGHEVVGEV 75 + G L + + ++ I + G+CHTDLH D + P+V GHE G V Sbjct: 13 ESHGKLEYKDIPVPKPKANELLINVKYSGVCHTDLHAWHGDWPLPVKLPLVGGHEGAGVV 72 Query: 76 VEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGF 135 V +G +V + +GD G+ L G C C CE E CP S G G F Sbjct: 73 VGMGENVKGWKIGDYAGIKWLNGSCMACEYCELGNESNCPHADLS-------GYTHDGSF 125 Query: 136 AKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILG-LGGVGH 194 + IP+G + Q AP+LCAG+TVY L L G I G GG+G Sbjct: 126 QQYATADAVQAAHIPQGTDLAQVAPILCAGITVYKALKSANLM-AGHWVAISGAAGGLGS 184 Query: 195 MGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQ-----AKMSELADSLDYVI 249 + V+ AKAMG + + + +EE + +G + ++ + + A + VI Sbjct: 185 LAVQYAKAMG-YRVLGIDGGEGKEELFRSIGGEVFIDFTKEKDIVGAVLKATDGGAHGVI 243 Query: 250 DTVPVHHALEPYLSLLKLDGKLILMGVI-NNPLQFLTPLLMLGRKVITGSFIGSMKETEE 308 + A+E ++ +G +L+G+ ++ I GS++G+ +T E Sbjct: 244 NVSVSEAAIEASTRYVRANGTTVLVGMPAGAKCCSDVFNQVVKSISIVGSYVGNRADTRE 303 Query: 309 MLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVD 349 L+F + S I+VV + + +E++EK + R+VVD Sbjct: 304 ALDFFARGLVKSPIKVVGLSTLPEIYEKMEKGQIVGRYVVD 344 >1CDO-A nrPDB Length = 374 Score = 282 bits (722), Expect = 1e-76, Method: Composition-based stats. Identities = 81/369 (21%), Positives = 144/369 (39%), Gaps = 29/369 (7%) Query: 9 KTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPG 68 K A + + L + ++ I+II G+CHTDL+ +P+V G Sbjct: 8 KCKAAVAWEANKPLVIEEIEVDVPHANEIRIKIIATGVCHTDLYHLFEGKHKDGFPVVLG 67 Query: 69 HEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYING 128 HE G V VG V++F G+ V + + CG C C+ C K + + ++ Sbjct: 68 HEGAGIVESVGPGVTEFQPGEKV-IPLFISQCGECRFCQSPKTNQCVKGWANESPDVMSP 126 Query: 129 QPT--------------QGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSH 174 + T F++ TVV+Q V KI ++ L C T + + Sbjct: 127 KETRFTCKGRKVLQFLGTSTFSQYTVVNQIAVAKIDPSAPLDTVCLLGCGVSTGFGAAVN 186 Query: 175 FGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSD 234 +PG + GLG VG V + G + N + E + GA D+V +D Sbjct: 187 TAKVEPGSTCAVFGLGAVGLAAVMGCHSAGAKRIIAVDLNPDKFEKAKVFGATDFVNPND 246 Query: 235 QAKM------SELADSLDYVIDTVPVHHALEPYL-SLLKLDGKLILMGVINNPLQFLTPL 287 ++ +D+ ++ V + L S LK G +L+G + P+ Sbjct: 247 HSEPISQVLSKMTNGGVDFSLECVGNVGVMRNALESCLKGWGVSVLVGWTDLHDVATRPI 306 Query: 288 LMLGRKVITGSFIGSMKETEEMLEFCK---EKGLS---SIIEVVKMDYVNTAFERLEKND 341 ++ + GS G K + + + K +K + I + ++ VN A + ++ Sbjct: 307 QLIAGRTWKGSMFGGFKGKDGVPKMVKAYLDKKVKLDEFITHRMPLESVNDAIDLMKHGK 366 Query: 342 VRYRFVVDV 350 R V+ + Sbjct: 367 CI-RTVLSL 374 >6C49-A nrPDB Length = 350 Score = 278 bits (711), Expect = 3e-75, Method: Composition-based stats. Identities = 105/341 (30%), Positives = 163/341 (47%), Gaps = 8/341 (2%) Query: 11 TGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHE 70 +AA L PY + E P V +++ CG+CH+D+ N+ + YP+V GHE Sbjct: 15 QAYAAMQAGEKLVPYKFDAGELQPHQVEVKVEYCGLCHSDISVLNNEWHSTVYPVVAGHE 74 Query: 71 VVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQP 130 ++G +V +GS+ +G VG+G C C C + C + Sbjct: 75 IIGRIVALGSEAKGLQIGQRVGIGWTAESCQACDECIGGQQVLCT------GENIATIVG 128 Query: 131 TQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLG 190 GGFA ++ + +PE + E A PLLC G+TV+ PL Q G++G+G Sbjct: 129 HAGGFADKVRAGWQWAIPLPEDLDPESAGPLLCGGITVFDPLLKH-KIQATHHVGVIGIG 187 Query: 191 GVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDYVID 250 G+GH+ +K+ KA G +T SS+ K EE L+ +GAD V D + D ++ Sbjct: 188 GLGHIAIKLLKAWGCEITAFSSNPDKTEE-LKAMGADHVVNSRDTEAVKAQKGKFDLLLS 246 Query: 251 TVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEML 310 TV V ++S L +G L +G+ P+ L+ G K +TGS GS ++L Sbjct: 247 TVNVTLNWRAFISTLAPNGSLHFLGLTLEPVPVSVGSLIDGAKSVTGSPTGSPAALRQLL 306 Query: 311 EFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVE 351 +F K ++ IE+ M +N A ERL RYR V+ + Sbjct: 307 KFAARKKIAPQIELFPMSQLNEAIERLHSGQARYRIVLKAD 347 >1D1T-A nrPDB Length = 373 Score = 278 bits (710), Expect = 4e-75, Method: Composition-based stats. Identities = 79/374 (21%), Positives = 138/374 (36%), Gaps = 30/374 (8%) Query: 2 GIMEAERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMS 61 G K + S + ++V I+I+ GIC TD H K + +S Sbjct: 1 GTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTM-VS 59 Query: 62 NYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSY 121 +P++ GHE G V +G V+ GD V + + C C+ C C + + Sbjct: 60 KFPVIVGHEATGIVESIGEGVTTVKPGDKV-IPLFLPQCRECNACRNPDGNLCIRSDITG 118 Query: 122 NDVYINGQPT-------------QGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTV 168 V +G F + TVV + V KI + E+ + C T Sbjct: 119 RGVLADGTTRFTCKGKPVHHFLNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTG 178 Query: 169 YSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADD 228 Y G +PG + GLGGVG + K+ G + NK + E +GA + Sbjct: 179 YGAAVKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATE 238 Query: 229 YVIGSDQAK-----MSELAD-SLDYVIDTVPVHHALEPYLSLLKLD-GKLILMGVINNPL 281 + D K +SE+ ++ Y + + + L+ ++ G +++GV + Sbjct: 239 CISPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSAK 298 Query: 282 QFL-TPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSSI------IEVVKMDYVNTAF 334 P+L+ + G G +K +++ + E V+ ++ F Sbjct: 299 MLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITHVLPFKKISEGF 358 Query: 335 ERLEKNDVRYRFVV 348 E L R V+ Sbjct: 359 ELLNSGQSI-RTVL 371 >4RQU-A nrPDB Length = 375 Score = 277 bits (709), Expect = 5e-75, Method: Composition-based stats. Identities = 81/363 (22%), Positives = 137/363 (37%), Gaps = 33/363 (9%) Query: 8 RKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVP 67 + W A P L + +V I+I+ +CHTD++ + +P + Sbjct: 7 KAAVAWEAGKP---LVIEEVEVAPPQKHEVRIKILFTSLCHTDVYFWEAKGQTPLFPRIF 63 Query: 68 GHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSY------ 121 GHE G V VG V+ GD V + G CG C C + C + Sbjct: 64 GHEAGGIVESVGEGVTDLQPGDHV-LPIFTGECGECRHCHSEESNMCDLLRINTERGGMI 122 Query: 122 ----NDVYINGQPT-----QGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPL 172 + ING+P F++ TVVH V KI +++ + C T Sbjct: 123 HDGESRFSINGKPIYHFLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGAT 182 Query: 173 SHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIG 232 + + G I GLG VG + A+ G + N KR + ++ G + V Sbjct: 183 LNVAKPKKGQSVAIFGLGAVGLGAAEGARIAGASRIIGVDFNSKRFDQAKEFGVTECVNP 242 Query: 233 SDQAK-----MSELAD-SLDYVIDTVPVHHALEPYLSLLK-LDGKLILMGVINNPLQFLT 285 D K ++E+ D +D ++ A+ + G +L+GV + F T Sbjct: 243 KDHDKPIQQVIAEMTDGGVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDDAFKT 302 Query: 286 -PLLMLGRKVITGSFIGSMKETEEMLEFCKEKGL------SSIIEVVKMDYVNTAFERLE 338 P+ L + + G+F G+ K ++ ++ I V +N AF+ + Sbjct: 303 HPMNFLNERTLKGTFFGNYKPKTDIPGVVEKYMNKELELEKFITHTVPFSEINKAFDYML 362 Query: 339 KND 341 K + Sbjct: 363 KGE 365 >1Q1N-A nrPDB Length = 360 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 127/353 (35%), Positives = 190/353 (53%), Gaps = 10/353 (2%) Query: 4 MEAERKTTGWAARDPSGILSPYT--YTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMS 61 M K G A + +P Y + D++I+I CG+C +D+H G Sbjct: 1 MSYPEKFEGIAIQSHEDWKNPKKTKYDPKPFYDHDIDIKIEACGVCGSDIHCAAGHWGNM 60 Query: 62 NYPMVPGHEVVGEVVEVGSDV-SKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWS 120 P+V GHE+VG+VV++G S VG VGVG V C C C+ D E YC K + + Sbjct: 61 KMPLVVGHEIVGKVVKLGPKSNSGLKVGQRVGVGAQVFSCLECDRCKNDNEPYCTKFVTT 120 Query: 121 YNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQP 180 Y+ Y +G +QGG+A VH+ FVV IPE + AAPLLC G+TVYSPL G P Sbjct: 121 YSQPYEDGYVSQGGYANYVRVHEHFVVPIPENIPSHLAAPLLCGGLTVYSPLVRNGC-GP 179 Query: 181 GLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSE 240 G + GI+GLGG+G MG I+KAMG VIS S++KRE+A++ +GAD Y+ ++ E Sbjct: 180 GKKVGIVGLGGIGSMGTLISKAMGAETYVISRSSRKREDAMK-MGADHYIATLEEGDWGE 238 Query: 241 LA-DSLDYVIDTVPVHHALEPYL--SLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITG 297 D+ D ++ ++ + +K+ G+++ + + L I+ Sbjct: 239 KYFDTFDLIVVCASSLTDIDFNIMPKAMKVGGRIVSISIPEQHEMLSLKPYGLKAVSISY 298 Query: 298 SFIGSMKETEEMLEFCKEKGLSSIIEVVKMDY--VNTAFERLEKNDVRYRFVV 348 S +GS+KE ++L+ EK + +E + + V+ AFER+EK DVRYRF + Sbjct: 299 SALGSIKELNQLLKLVSEKDIKIWVETLPVGEAGVHEAFERMEKGDVRYRFTL 351 >1E3E-A nrPDB Length = 376 Score = 273 bits (697), Expect = 1e-73, Method: Composition-based stats. Identities = 73/371 (19%), Positives = 132/371 (35%), Gaps = 34/371 (9%) Query: 2 GIMEAERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMS 61 G K A L + +V I++I +C TD++ T + + Sbjct: 1 GTQGKVIKCKAAIAWKTGSPLCIEEIEVSPPKACEVRIQVIATCVCPTDINAT-DPKKKA 59 Query: 62 NYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIW-- 119 +P+V GHE G V VG V+ F GD V + C C C L C K Sbjct: 60 LFPVVLGHECAGIVESVGPGVTNFKPGDKV-IPFFAPQCKRCKLCLSPLTNLCGKLRNFK 118 Query: 120 -----------SYNDVYINGQPTQ-----GGFAKATVVHQKFVVKIPEGMAVEQAAPLLC 163 + G+ F++ TVV + + ++ + +E+ + C Sbjct: 119 YPTIDQELMEDRTSRFTCKGRSIYHFMGVSSFSQYTVVSEANLARVDDEANLERVCLIGC 178 Query: 164 AGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQD 223 + Y + PG + GLG VG + K G + N ++ + Sbjct: 179 GFSSGYGAAINTAKVTPGSTCAVFGLGCVGLSAIIGCKIAGASRIIAIDINGEKFPKAKA 238 Query: 224 LGADDYVIGSD-----QAKMSELA-DSLDYVIDTVPVHHALEPYLSL-LKLDGKLILMGV 276 LGA D + + Q ++EL +DY +D L+ + + G ++G Sbjct: 239 LGATDCLNPRELDKPVQDVITELTAGGVDYSLDCAGTAQTLKAAVDCTVLGWGSCTVVGA 298 Query: 277 INNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSSI------IEVVKMDYV 330 + + T ++LGR I G+F G K + + + + + + Sbjct: 299 KVDEMTIPTVDVILGR-SINGTFFGGWKSVDSVPNLVSDYKNKKFDLDLLVTHALPFESI 357 Query: 331 NTAFERLEKND 341 N A + +++ Sbjct: 358 NDAIDLMKEGK 368 >4GKV-A nrPDB Length = 336 Score = 272 bits (696), Expect = 1e-73, Method: Composition-based stats. Identities = 86/339 (25%), Positives = 148/339 (43%), Gaps = 12/339 (3%) Query: 14 AARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVG 73 A + TLR + +++ CCG+CHTDLH D G ++ GHE +G Sbjct: 4 AVVTKDHHVDVTYKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFG-DKTGVILGHEGIG 62 Query: 74 EVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQG 133 V EVG V+ GD V CG C C E C V G G Sbjct: 63 VVAEVGPGVTSLKPGDRASVAWFYEGCGHCEYCNSGNETLC-------RSVKNAGYSVDG 115 Query: 134 GFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVG 193 G A+ +V + VK+P+G+ A+ + CAGVT Y + +PG I GLGG+G Sbjct: 116 GMAEECIVVADYAVKVPDGLDSAAASSITCAGVTTYKAVK-LSKIRPGQWIAIYGLGGLG 174 Query: 194 HMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAK---MSELADSLDYVID 250 ++ ++ AK + + + N ++ + ++GAD + + + E + Sbjct: 175 NLALQYAKNVFNAKVIAIDVNDEQLKLATEMGADLAINSHTEDAAKIVQEKTGGAHAAVV 234 Query: 251 TVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEML 310 T A + ++ G+++ +G+ + P L+L + GS +G+ ++ E Sbjct: 235 TAVAKAAFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAF 294 Query: 311 EFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVD 349 +F E + + + + +NT F +E+ +R R V+D Sbjct: 295 QFAAEGKVVPKVALRPLADINTIFTEMEEGKIRGRMVID 333 >5YAT-A nrPDB Length = 350 Score = 270 bits (690), Expect = 7e-73, Method: Composition-based stats. Identities = 84/338 (24%), Positives = 150/338 (44%), Gaps = 15/338 (4%) Query: 19 SGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMS-NYPMVPGHEVVGEVVE 77 G L + + ++ I + G+CHTDLH K D + P+V GHE G VV Sbjct: 18 GGPLEYKDIPVPKPKSNELLINVKYSGVCHTDLHAWKGDWPLDNKLPLVGGHEGAGVVVA 77 Query: 78 VGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAK 137 G +V+ + +GD G+ L G C C C + E C K S G G F + Sbjct: 78 YGENVTGWEIGDYAGIKWLNGSCLNCEYCIQGAESSCAKADLS-------GFTHDGSFQQ 130 Query: 138 ATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGV 197 +IP+ + + AP+LCAG+TVY L L+ GG+G + V Sbjct: 131 YATADATQAARIPKEADLAEVAPILCAGITVYKALKTADLRIGQWVAISGAGGGLGSLAV 190 Query: 198 KIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSE-----LADSLDYVIDTV 252 + AKA+G + + E ++ LGA+ +V + + VI+ Sbjct: 191 QYAKALGL-RVLGIDGGADKGEFVKSLGAEVFVDFTKTKDVVAEVQKLTNGGPHGVINVS 249 Query: 253 PVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLL-MLGRKVITGSFIGSMKETEEMLE 311 HA+ + ++ GK++L+G+ + + +L I GS++G+ +++ E ++ Sbjct: 250 VSPHAINQSVQYVRTLGKVVLVGLPSGAVVNSDVFWHVLKSIEIKGSYVGNREDSAEAID 309 Query: 312 FCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVD 349 + + I+++ + + +E++E + R+VVD Sbjct: 310 LFTRGLVKAPIKIIGLSELAKVYEQMEAGAIIGRYVVD 347 >1R37-A nrPDB Length = 347 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 88/345 (25%), Positives = 149/345 (43%), Gaps = 24/345 (6%) Query: 19 SGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLG--------MSNYPMVPGHE 70 LS + + V I++ G+CH+D+H + G P+ GHE Sbjct: 10 GKPLSLQEIGVPKPKGPQVLIKVEAAGVCHSDVHMRQGRFGNLRIVEDLGVKLPVTLGHE 69 Query: 71 VVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQP 130 + G++ EVG +V ++ GD+V V G G C C E C W G Sbjct: 70 IAGKIEEVGDEVVGYSKGDLVAVNPWQGE-GNCYYCRIGEEHLCDSPRW-------LGIN 121 Query: 131 TQGGFAKATVV-HQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGL 189 G +A+ +V H K++ K+ + +AAPL C+G+T Y + L + Sbjct: 122 FDGAYAEYVIVPHYKYMYKLRR-LNAVEAAPLTCSGITTYRAVRKASLDPTKTLLVVGAG 180 Query: 190 GGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL-----ADS 244 GG+G M V+IAKA+ + ++ EA + GAD + S Q ++E+ + Sbjct: 181 GGLGTMAVQIAKAVSGATIIGVDVREEAVEAAKRAGADYVINASMQDPLAEIRRITESKG 240 Query: 245 LDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMK 304 +D VID L Y L GK +++G+ L + PL+ L GS +G+ Sbjct: 241 VDAVIDLNNSEKTLSVYPKALAKQGKYVMVGLFGADLHYHAPLITLSEIQFVGSLVGNQS 300 Query: 305 ETEEMLEFCKEKGLSSII-EVVKMDYVNTAFERLEKNDVRYRFVV 348 + ++ + + +I + +K++ N A + LE R V+ Sbjct: 301 DFLGIMRLAEAGKVKPMITKTMKLEEANEAIDNLENFKAIGRQVL 345 >1H2B-A nrPDB Length = 359 Score = 267 bits (683), Expect = 5e-72, Method: Composition-based stats. Identities = 90/330 (27%), Positives = 145/330 (43%), Gaps = 20/330 (6%) Query: 30 RETGPEDVNIRIICCGICHTDLHQTKNDLG---MSNYPMVPGHEVVGEVVEVGSDVSKFT 86 R G DV +RI G+CHTDLH + P GHE VG + EV V Sbjct: 37 RLEGRFDVIVRIAGAGVCHTDLHLVQGMWHELLQPKLPYTLGHENVGYIEEVAEGVEGLE 96 Query: 87 VGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFV 146 GD V + V G C C + +C ++ G GGFA+ + V Sbjct: 97 KGDPVILHPAVTD-GTCLACRAGEDMHCE-------NLEFPGLNIDGGFAEFMRTSHRSV 148 Query: 147 VKIPEGMAVE---QAAPLLCAGVTVYSPLSHFGL-KQPGLRGGILGLGGVGHMGVKIAKA 202 +K+P+ ++ E + APL AG+T Y + PG I+G+GG+GH+ V++ K Sbjct: 149 IKLPKDISREKLVEMAPLADAGITAYRAVKKAARTLYPGAYVAIVGVGGLGHIAVQLLKV 208 Query: 203 MGHHVTVISSSNKKREEALQDLGADDYVI----GSDQAKMSELADSLDYVIDTVPVHHAL 258 M + +++ + + LGAD V Q ++ +D V + Sbjct: 209 MTPATVIALDVKEEKLKLAERLGADHVVDARRDPVKQVMELTRGRGVNVAMDFVGSQATV 268 Query: 259 EPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGL 318 + LL G+LI++G L+F T ++ GS +G+ E E++ + + Sbjct: 269 DYTPYLLGRMGRLIIVG-YGGELRFPTIRVISSEVSFEGSLVGNYVELHELVTLALQGKV 327 Query: 319 SSIIEVVKMDYVNTAFERLEKNDVRYRFVV 348 +++ K+D +N ERLEK +V R V+ Sbjct: 328 RVEVDIHKLDEINDVLERLEKGEVLGRAVL 357 >1P0F-A nrPDB Length = 373 Score = 260 bits (665), Expect = 6e-70, Method: Composition-based stats. Identities = 88/368 (23%), Positives = 144/368 (39%), Gaps = 30/368 (8%) Query: 1 MGIMEAERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGM 60 M + A +P LS T T+ +V I+I+ GIC +D K ++ Sbjct: 1 MCTAGKDITCKAAVAWEPHKPLSLETITVAPPKAHEVRIKILASGICGSDSSVLK-EIIP 59 Query: 61 SNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWS 120 S +P++ GHE VG V +G+ V+ GD V + V CG C C+ +C K Sbjct: 60 SKFPVILGHEAVGVVESIGAGVTCVKPGDKV-IPLFVPQCGSCRACKSSNSNFCEKNDMG 118 Query: 121 ---------YNDVYINGQPT-----QGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGV 166 + G+P F + TVV V KI +E + C Sbjct: 119 AKTGLMADMTSRFTCRGKPIYNLMGTSTFTEYTVVADIAVAKIDPKAPLES-CLIGCGFA 177 Query: 167 TVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGA 226 T Y + PG + GLGGVG + KA G + ++K + +LGA Sbjct: 178 TGYGAAVNTAKVTPGSTCAVFGLGGVGFSAIVGCKAAGASRIIGVGTHKDKFPKAIELGA 237 Query: 227 DDYVIGSDQAK------MSELADSLDYVIDTVP-VHHALEPYLSLLKLDGKLILMGVI-N 278 + + D K + +DY ++ + + S G +++G+ Sbjct: 238 TECLNPKDYDKPIYEVICEKTNGGVDYAVECAGRIETMMNALQSTYCGSGVTVVLGLASP 297 Query: 279 NPLQFLTPLLMLGRKVITGSFIGSMK--ETEEMLEFCKEKGLSS---IIEVVKMDYVNTA 333 N L PLL+L + + GS G K E +++ +K ++ + + +D +N A Sbjct: 298 NERLPLDPLLLLTGRSLKGSVFGGFKGEEVSRLVDDYMKKKINVNFLVSTKLTLDQINKA 357 Query: 334 FERLEKND 341 FE L Sbjct: 358 FELLSSGQ 365 >5K1S-A nrPDB Length = 362 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 81/348 (23%), Positives = 152/348 (43%), Gaps = 17/348 (4%) Query: 9 KTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPG 68 K + +G L T + G +V +R+ CG+C+ D+ + +L ++ P + G Sbjct: 19 KAVVLRSFGEAGNLKMETMPMPRPGRGEVLLRVHACGVCYHDVINRRGNLPRTSVPAILG 78 Query: 69 HEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYING 128 HE GEV+EVG D + GD + CG C+ C C D G Sbjct: 79 HEAAGEVIEVGPDTPGWKTGDRAATLQRM-SCGDCALCRSGRNSLCK------TDNRFFG 131 Query: 129 QPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILG 188 + GG+A+ V + ++P + +AA + C T + G + G I G Sbjct: 132 EELPGGYAQFMVAPVGGLGRVPASLPWNEAATVCCTTGTAVHTVRTRGKVRAGETVLITG 191 Query: 189 L-GGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELAD---- 243 GGVG V++A+ G + +S++ + +AL++ GAD+ ++ S++ Sbjct: 192 ASGGVGLSSVQLARLDGA-RVIAVTSSEAKVQALKEAGADEVIVSRGLDFASDVRKRTQG 250 Query: 244 -SLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTP-LLMLGRKVITGSFIG 301 +D ++ V + L + G+++++G + + + L P L+++ I G++ Sbjct: 251 AGVDVAVEIVGS-ATFDQTLKSMAPGGRVVVVGNLESGMVQLNPGLVIVKELEILGAYAT 309 Query: 302 SMKETEEMLEFCKEKGLSSII-EVVKMDYVNTAFERLEKNDVRYRFVV 348 + E +E L G+ + + V + A RLE +V R V+ Sbjct: 310 TQAELDEALRLTATGGVRQFVTDAVPLAEAAKAHFRLENREVAGRLVL 357 >2DFV-A nrPDB Length = 347 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 90/361 (24%), Positives = 142/361 (39%), Gaps = 34/361 (9%) Query: 9 KTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMS---NYPM 65 K P + + GP +V I+++ IC TDLH + + P Sbjct: 3 KMVAIMKTKPGYGAELVEVDVPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIKPPQ 62 Query: 66 VPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVY 125 + GHEV GEVVE+G V VGD V V + CG C C R C + Sbjct: 63 IMGHEVAGEVVEIGPGVEGIEVGDYVSVETHI-VCGKCYACRRGQYHVCQ-------NTK 114 Query: 126 INGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAA---PLLCAGVTVYSPLSHFGLKQPGL 182 I G T G FA+ VV + + K P+ + E A PL A TV G Sbjct: 115 IFGVDTDGVFAEYAVVPAQNIWKNPKSIPPEYATLQEPLGNAVDTV------LAGPISGK 168 Query: 183 RGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELA 242 I G G +G +G+ +AKA G + ++S + R E + +GAD + ++ + E+ Sbjct: 169 SVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVM 228 Query: 243 D-----SLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLT-PLLMLGRKVIT 296 D +D ++ ALE L + G++ L+G+ + L++ I Sbjct: 229 DITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVTIDFNNLIIFKALTIY 288 Query: 297 GS----FIGSMKETEEMLEFCKEKGLSSII--EVVKMDYVNTAFERLEKNDVRYRFVVDV 350 G + +L+ + L II + D AFE + + V + Sbjct: 289 GITGRHLWETWYTVSRLLQ-SGKLNLDPIITHKYKGFDKYEEAFELMRAGKT-GKVVFML 346 Query: 351 E 351 + Sbjct: 347 K 347 >5YLN-A nrPDB Length = 356 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 84/336 (25%), Positives = 134/336 (39%), Gaps = 18/336 (5%) Query: 33 GPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVG 92 P D +RI+ IC TDLH K D+ + GHE +G V EVG VS F GD V Sbjct: 28 KPTDAIVRIVKTTICGTDLHIIKGDVPTCQSGTILGHEGIGIVEEVGEGVSNFKKGDKVL 87 Query: 93 VGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVH--QKFVVKIP 150 + C V CG C C++ + +C + +I G G A+ V + P Sbjct: 88 ISC-VCACGKCYYCKKGIYAHCEDEGG-----WIFGHLIDGMQAEYLRVPHADNTLYHTP 141 Query: 151 EGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVI 210 E ++ E L T Y G +PG I+G G VG + A+ ++ Sbjct: 142 EDLSDEALVMLSDILPTGYEIGVLKGKVEPGCSVAIIGSGPVGLAALLTAQFYSPAKLIM 201 Query: 211 SSSNKKREEALQDLGADDYVIGSDQAK-MSELAD-----SLDYVIDTVPVHHALEPYLSL 264 + R E GA V SD K + E+ D +D I+ V + + + Sbjct: 202 VDLDDNRLETALSFGATHKVNSSDPEKAIKEIYDLTDGRGVDVAIEAVGIPATFDFCQKI 261 Query: 265 LKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSS---I 321 + +DG + GV P++F L + +T + S T ++L+ + + + Sbjct: 262 IGVDGTVANCGVHGKPVEFDLDKLWIRNINVTTGLV-STNTTPQLLKALESHKIEPEKLV 320 Query: 322 IEVVKMDYVNTAFERLEKNDVRYRFVVDVEGSNLDA 357 K+ + A+E K + V +E +A Sbjct: 321 THYFKLSEIEKAYEVFSKAADHHAIKVIIENDISEA 356 >2H6E-A nrPDB Length = 344 Score = 247 bits (630), Expect = 7e-66, Method: Composition-based stats. Identities = 94/350 (26%), Positives = 150/350 (42%), Gaps = 18/350 (5%) Query: 8 RKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMS--NYPM 65 K+ + S LS + E E+V IRI G+C TDL K P+ Sbjct: 2 VKSKAALLKKFSEPLSIEDVNIPEPQGEEVLIRIGGAGVCRTDLRVWKGVEAKQGFRLPI 61 Query: 66 VPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVY 125 + GHE G +VEVG ++K GD V V G C C C +I Sbjct: 62 ILGHENAGTIVEVGE-LAKVKKGDNVVVYATWGDL-TCRYCREGKFNICKNQI------- 112 Query: 126 INGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSH---FGLKQPGL 182 I GQ T GGF++ +V + ++ +AAPL AG T + F K Sbjct: 113 IPGQTTNGGFSEYMLVKSSRWLVKLNSLSPVEAAPLADAGTTSMGAIRQALPFISKFAEP 172 Query: 183 RGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKRE-EALQDLGADDYVIGSD-QAKMSE 240 + G+GG+ ++I KA+ ++T++ S K+ + +LGAD D ++ +++ Sbjct: 173 VVIVNGIGGLAVYTIQILKALMKNITIVGISRSKKHRDFALELGADYVSEMKDAESLINK 232 Query: 241 LADSL--DYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGS 298 L D L ID V LL +G +IL+G+ + + K + GS Sbjct: 233 LTDGLGASIAIDLVGTEETTYNLGKLLAQEGAIILVGMEGKRVSLEAFDTAVWNKKLLGS 292 Query: 299 FIGSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVV 348 GS+ + E+++ + + I V +D +N AF L++ V R V+ Sbjct: 293 NYGSLNDLEDVVRLSESGKIKPYIIKVPLDDINKAFTNLDEGRVDGRQVI 342 >1F8F-A nrPDB Length = 371 Score = 246 bits (629), Expect = 8e-66, Method: Composition-based stats. Identities = 74/352 (21%), Positives = 136/352 (38%), Gaps = 31/352 (8%) Query: 18 PSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVE 77 +R+ ++V ++++ G+CHTDL + P V GHE G + Sbjct: 15 KGADFELQALKIRQPQGDEVLVKVVATGMCHTDLIVRDQKYPVP-LPAVLGHEGSGIIEA 73 Query: 78 VGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCP---------------KKIWSYN 122 +G +V++ VGD V + G CG C+ C YC + +++ Sbjct: 74 IGPNVTELQVGDHVVLS--YGYCGKCTQCNTGNPAYCSEFFGRNFSGADSEGNHALCTHD 131 Query: 123 DVYINGQP-TQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPG 181 +N Q FA + + VK+ + + +E PL C T + P Sbjct: 132 QGVVNDHFFAQSSFATYALSRENNTVKVTKDVPIELLGPLGCGIQTGAGACINALKVTPA 191 Query: 182 LRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL 241 G G VG + AK G + + + R E + LGA + Q ++ + Sbjct: 192 SSFVTWGAGAVGLSALLAAKVCGASIIIAVDIVESRLELAKQLGATHVINSKTQDPVAAI 251 Query: 242 A----DSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVI--NNPLQFLTPLLMLGRKVI 295 +++ +++ L+ + L + GK+ ++G QF L+LG K I Sbjct: 252 KEITDGGVNFALESTGSPEILKQGVDALGILGKIAVVGAPQLGTTAQFDVNDLLLGGKTI 311 Query: 296 TGSFIGSMKETEEMLEFCK--EKGLSSIIEVVKMDYVNTAFERLEKNDVRYR 345 G GS + + E + ++G ++VK AF+ + + + R Sbjct: 312 LGVVEGSGSPKKFIPELVRLYQQGKFPFDQLVKF----YAFDEINQAAIDSR 359 >3GFB-A nrPDB Length = 350 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 86/358 (24%), Positives = 140/358 (39%), Gaps = 34/358 (9%) Query: 9 KTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMS---NYPM 65 K P+ + + GP +V I+++ IC TDLH + + P Sbjct: 4 KMQAIMKTKPAYGAELVEVDVPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIKPPQ 63 Query: 66 VPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVY 125 + GHEV GEVVEVG V VGD + V + CG C C+ + C + Sbjct: 64 IMGHEVAGEVVEVGPGVEDLQVGDYISVETHI-VCGKCYACKHNRYHVCQ-------NTK 115 Query: 126 INGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAA---PLLCAGVTVYSPLSHFGLKQPGL 182 I G G FA +V K K P+ M E AA PL A TV G Sbjct: 116 IFGVDMDGVFAHYAIVPAKNAWKNPKDMPPEYAALQEPLGNAVDTV------LAGPIAGR 169 Query: 183 RGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELA 242 I G G +G +G+ +AKA G + ++S ++ R + + +GAD V ++ + + Sbjct: 170 STLITGAGPLGLLGIAVAKASGAYPVIVSEPSEFRRKLAKKVGADYVVNPFEEDPVKFVM 229 Query: 243 D-----SLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLT-PLLMLGRKVIT 296 D ++ ++ ALE L + G++ L+G+ + L++ + Sbjct: 230 DITDGAGVEVFLEFSGAPKALEQGLKAVTPGGRVSLLGLFPREVTIDFNNLIIFKALEVH 289 Query: 297 GS----FIGSMKETEEMLEFCKEKGLSSII--EVVKMDYVNTAFERLEKNDVRYRFVV 348 G + +++ + L II + D AFE + + V Sbjct: 290 GITGRHLWETWYTVSSLIQ-SGKLNLDPIITHKYKGFDKFEEAFELMRAGKT-GKVVF 345 >6FG0-A nrPDB Length = 352 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 80/330 (24%), Positives = 138/330 (41%), Gaps = 10/330 (3%) Query: 26 TYTLRETGPEDVNIRIICCGICHTDLHQTKND--LGMSNYPMVPGHEVVGEVVEVGSDVS 83 GP ++ +++ G+CH+D+ P+ GHE VG V E+G V+ Sbjct: 17 DIPTPTPGPGEILLKVTAAGLCHSDITVMDMPAAQYAGGLPLTLGHEGVGTVAELGEGVT 76 Query: 84 KFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQ 143 F VGD V V G CG C C R E YC + + G + G A+ +V Sbjct: 77 GFGVGDAVAVYGPWG-CGACHACARGRENYCTRAADLG--ITPPGYGSPGSMAEYMIVDS 133 Query: 144 KFVVKIPEGMAVEQAAPLLCAGVTVYSPLSH-FGLKQPGLRGGILGLGGVGHMGVKIAKA 202 + + AAPL AG+T Y +S L PG ++G+GG+GH+G++I +A Sbjct: 134 ARHLVPIGDLDPVAAAPLTDAGLTPYHAISRVLPLLGPGSTAVVIGVGGLGHVGIQILRA 193 Query: 203 MGHHVTVISSSNKKREEALQDLGADDYVIG----SDQAKMSELADSLDYVIDTVPVHHAL 258 + + + R +++GAD V +D + V D V + Sbjct: 194 VSAARVIAVDLDDDRLALAREVGADAAVKSGAGAADAIRELTGGQGATAVFDFVGAQSTI 253 Query: 259 EPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGL 318 + ++ +DG + ++G+ + ++ + + G+ E E++ + L Sbjct: 254 DTAQQVVAVDGHISVVGIHAGAHAKVGFWMIPFGASVVTPYWGTRSELMEVVALARAGRL 313 Query: 319 SSIIEVVKMDYVNTAFERLEKNDVRYRFVV 348 E +D A+ RL + +R R VV Sbjct: 314 DIHTETFTLDEGPAAYRRLREGSIRGRGVV 343 >3WLE-A nrPDB Length = 341 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 86/349 (24%), Positives = 146/349 (41%), Gaps = 13/349 (3%) Query: 2 GIMEAERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMS 61 G M G+ SG+ + + + +++ G+CH+DLH L Sbjct: 4 GAMSIPSSQYGFVFNKQSGLKLRNDLPVHKPKAGQLLLKVDAVGLCHSDLHVIYEGLDCG 63 Query: 62 NYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSY 121 V GHE+ G V VG DV + VGD V G CGGC C ++ C ++ Sbjct: 64 -DNYVMGHEIAGTVAAVGDDVINYKVGDRVACVGPNG-CGGCKYCRGAIDNVCKN---AF 118 Query: 122 NDVYINGQPTQGGFAKATVV-HQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQP 180 D + G GG+ + +V + + +IP+ ++ + AA A +T Y + P Sbjct: 119 GDWFGLGY--DGGYQQYLLVTRPRNLSRIPDNVSADVAAASTDAVLTPYHAIKM-AQVSP 175 Query: 181 GLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSE 240 ++G GG+G +++AKA G VTV+ K+ + + LGAD + S Sbjct: 176 TSNILLIGAGGLGGNAIQVAKAFGAKVTVL-DKKKEARDQAKKLGADAVY---ETLPESI 231 Query: 241 LADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFI 300 S D V V + ++ G ++ +G+ L F L L I GSF Sbjct: 232 SPGSFSACFDFVSVQATFDVCQKYVEPKGVIMPVGLGAPNLSFNLGDLALREIRILGSFW 291 Query: 301 GSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVD 349 G+ + +++L+ E + ++ K+ + E+L N R V + Sbjct: 292 GTTNDLDDVLKLVSEGKVKPVVRSAKLKELPEYIEKLRNNAYEGRVVFN 340 >1PL8-A nrPDB Length = 356 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 68/333 (20%), Positives = 126/333 (37%), Gaps = 21/333 (6%) Query: 20 GILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKND---LGMSNYPMVPGHEVVGEVV 76 G L Y + E GP +V +R+ GIC +D+H + + PMV GHE G V Sbjct: 17 GDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVE 76 Query: 77 EVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFA 136 +VGS V GD V + C+ P + + P G Sbjct: 77 KVGSSVKHLKPGDRVAIEPGAPR-ENDEFCKMGRYNLSP------SIFFCATPPDDGNLC 129 Query: 137 KATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMG 196 + + F K+P+ + E+ A + V ++ G G + + G G +G + Sbjct: 130 RFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIH--ACRRGGVTLGHKVLVCGAGPIGMVT 187 Query: 197 VKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMS-------ELADSLDYVI 249 + +AKAMG V++ + R +++GAD + S ++ +L + I Sbjct: 188 LLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTI 247 Query: 250 DTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSF-IGSMKETEE 308 + +++ + + G L+L+G+ + + I G F + Sbjct: 248 ECTGAEASIQAGIYATRSGGTLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAI 307 Query: 309 MLEFCKEKGLSSII-EVVKMDYVNTAFERLEKN 340 + K + ++ ++ AFE +K Sbjct: 308 SMLASKSVNVKPLVTHRFPLEKALEAFETFKKG 340 >5TNX-A nrPDB Length = 383 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 69/340 (20%), Positives = 123/340 (36%), Gaps = 33/340 (9%) Query: 24 PYTYT---LRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGS 80 P++ +R ++V +R++ G+CHTDL ++ P V GHE G V VG Sbjct: 29 PFSIEPARIRAPRGDEVLVRVVATGLCHTDL-IVRDQYYPVPLPAVLGHEGAGVVEAVGP 87 Query: 81 DVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKI-WSYNDVYINGQPT-------- 131 +V GD V + G CG C+ C YC + ++ +GQ Sbjct: 88 NVKTLAAGDHVVL--TYGACGHCASCAGGHGAYCRQFFALNFGGADADGQTALRDAAGEP 145 Query: 132 -------QGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRG 184 Q FA + + +K+P+ +E PL C T + + + G Sbjct: 146 LHDHFFAQSSFASYALARENNAIKVPKEAPLELLGPLGCGIQTGAGAVINSLAVRTGSSF 205 Query: 185 GILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL--- 241 G G VG V A+ G + R +LGA + + + + Sbjct: 206 ASFGAGAVGMSAVMAARIAGATTIIAVDIVPSRLALALELGATHAINSKEVDVVDAIREI 265 Query: 242 -ADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVI--NNPLQFLTPLLMLGRKVITGS 298 +DY +++ + L + L G + ++G +F L+LG I G Sbjct: 266 TGGGVDYALESTGLPAVLSQGIDALGSRGTMGVVGAPKLGTKAEFDVNSLLLGGHTIRGI 325 Query: 299 FIGSMKETEEMLEFCKEKG-----LSSIIEVVKMDYVNTA 333 G + + + +++ ++ +N A Sbjct: 326 VEGDSVPQTFIPQLVQLHLQGRFPFDRLVKFYPLEQINQA 365 >1E3J-A nrPDB Length = 352 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 77/335 (22%), Positives = 130/335 (38%), Gaps = 26/335 (7%) Query: 20 GILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMS---NYPMVPGHEVVGEVV 76 L + E ++V +++ GIC +D+H ++ PMV GHE G VV Sbjct: 14 NDLRLEQRPIPEPKEDEVLLQMAYVGICGSDVHYYEHGRIADFIVKDPMVIGHEASGTVV 73 Query: 77 EVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFA 136 +VG +V GD V V V C C C+ CP + P G A Sbjct: 74 KVGKNVKHLKKGDRVAVEPGVP-CRRCQFCKEGKYNLCPDL------TFCATPPDDGNLA 126 Query: 137 KATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMG 196 + V F K+P+ +++E+ A L V V+ Q G ++G G +G + Sbjct: 127 RYYVHAADFCHKLPDNVSLEEGALLEPLSVGVH--ACRRAGVQLGTTVLVIGAGPIGLVS 184 Query: 197 VKIAKAMGHHVTVISSSNKKREEALQDLGADD--YVIGSDQAK-------MSELADSLDY 247 V AKA G V V ++ + +R E ++ GAD V + + + S + D + Sbjct: 185 VLAAKAYGAFV-VCTARSPRRLEVAKNCGADVTLVVDPAKEEESSIIERIRSAIGDLPNV 243 Query: 248 VIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETE 307 ID + +++ + G L+L+G+ + + I S + Sbjct: 244 TIDCSGNEKCITIGINITRTGGTLMLVGMGSQMVTVPLVNACAREIDIK-SVFRYCNDYP 302 Query: 308 EMLEFCKEK--GLSSII-EVVKMDYVNTAFERLEK 339 LE + ++ K++ AFE K Sbjct: 303 IALEMVASGRCNVKQLVTHSFKLEQTVDAFEAARK 337 >5KIA-A nrPDB Length = 351 Score = 226 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 90/339 (26%), Positives = 135/339 (39%), Gaps = 23/339 (6%) Query: 22 LSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSN---YPMVPGHEVVGEVVEV 78 L+ E G DV I+I IC TD+H K D PM GHE VGE+VE+ Sbjct: 21 LTLTRVKKPEVGHNDVLIKIRRTAICGTDIHIWKWDDWAQKTIPVPMHVGHEYVGEIVEM 80 Query: 79 GSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKA 138 G +V F++GD V G CG C C C + G +G FA+ Sbjct: 81 GQEVRGFSIGDRVS-GEGHITCGFCRNCRAGRRHLCRNTVG-------VGVNREGAFAEY 132 Query: 139 TVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVK 198 + KIP ++ + AA G ++ LS + G I G G +G M V Sbjct: 133 LAIPAFNAFKIPPEISDDLAAIFDPFGNATHTALSFNLV---GEDVLITGAGPIGVMAVA 189 Query: 199 IAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELAD-----SLDYVIDTVP 253 IAK +G VI+ N R + + +GA V S ++ +AD D ++ Sbjct: 190 IAKHVGARNVVITDINDYRLDLARRMGATRAVNVSRESLRDVMADLHMTEGFDVGLEMSG 249 Query: 254 VHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKET-EEMLEF 312 V A L + GK+ L+G+ ++ I G + M ET +M+ Sbjct: 250 VPSAFTSLLESMNHGGKVALLGIPPAQTAIDWNQVIFKGLEIKGIYGREMFETWYKMVAM 309 Query: 313 CKEK-GLSSII-EVVKMDYVNTAFERLEKNDVRYRFVVD 349 + LS II +D F + + + ++D Sbjct: 310 LQSGLDLSPIITHRFAVDDYEKGFAAMLSGE-SGKVILD 347 >3QE3-A nrPDB Length = 355 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 68/334 (20%), Positives = 126/334 (37%), Gaps = 23/334 (6%) Query: 20 GILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKND---LGMSNYPMVPGHEVVGEVV 76 G L Y + E GP +V +++ GIC +D+H ++ + PMV GHE G VV Sbjct: 16 GDLRLENYPIPEPGPNEVLLKMHSVGICGSDVHYWQHGRIGDFVVKKPMVLGHEASGTVV 75 Query: 77 EVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFA 136 +VGS V GD V + C+ P + P G Sbjct: 76 KVGSLVRHLQPGDRVAIQPGAPR-QTDEFCKIGRYNLSP------TIFFCATPPDDGNLC 128 Query: 137 KATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMG 196 + + F K+P+ + E+ A + V ++ G + + G G +G + Sbjct: 129 RFYKHNANFCYKLPDNVTFEEGALIEPLSVGIH--ACRRAGVTLGNKVLVCGAGPIGLVN 186 Query: 197 VKIAKAMGHHVTVISSSNKKREEALQDLGADDY--VIGSDQAKMSELADSL-----DYVI 249 + AKAMG V++ + R +++GAD + ++++ + L + I Sbjct: 187 LLAAKAMGAAQVVVTDLSASRLSKAKEVGADFILEISNESPEEIAKKVEGLLGSKPEVTI 246 Query: 250 DTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGS--FIGSMKETE 307 + V +++ + G L+L+G+ + I G + + Sbjct: 247 ECTGVETSIQAGIYATHSGGTLVLVGLGSEMTSVPLVHAATREVDIKGVFRYCNTWPMAI 306 Query: 308 EMLEFCKEKGLSSII-EVVKMDYVNTAFERLEKN 340 ML K + ++ ++ AFE +K Sbjct: 307 SML-ASKSVNVKPLVTHRFPLEKALEAFETSKKG 339 >2DQ4-A nrPDB Length = 343 Score = 223 bits (569), Expect = 8e-59, Method: Composition-based stats. Identities = 77/343 (22%), Positives = 127/343 (37%), Gaps = 25/343 (7%) Query: 12 GWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDL---GMSNYPMVPG 68 A P L+ + E GP ++ +R+ IC TDLH K D G P+V G Sbjct: 3 ALAKLAPEEGLTLVDRPVPEPGPGEILVRVEAASICGTDLHIWKWDAWARGRIRPPLVTG 62 Query: 69 HEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYING 128 HE G V VG V + VGD V + + C C C C + I G Sbjct: 63 HEFSGVVEAVGPGVRRPQVGDHVSLESHI-VCHACPACRTGNYHVCL-------NTQILG 114 Query: 129 QPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILG 188 GGFA+ VV + P+ + E AA L G V++ + G+ G I G Sbjct: 115 VDRDGGFAEYVVVPAENAWVNPKDLPFEVAAILEPFGNAVHTVYAGSGVS--GKSVLITG 172 Query: 189 LGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMS----ELADS 244 G +G M + +A G ++S N R + AD V ++ + Sbjct: 173 AGPIGLMAAMVVRASGAGPILVSDPNPYRLAFARPY-ADRLVNPLEEDLLEVVRRVTGSG 231 Query: 245 LDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFL-TPLLMLGRKVITGSFIGSM 303 ++ +++ A+ L L G+ ++G+ ++P++F L++ G G Sbjct: 232 VEVLLEFSGNEAAIHQGLMALIPGGEARILGIPSDPIRFDLAGELVMRGITAFG-IAGRR 290 Query: 304 --KETEEMLEFCKEKGLS---SIIEVVKMDYVNTAFERLEKND 341 + + + + + + AF L Sbjct: 291 LWQTWMQGTALVYSGRVDLSPLLTHRLPLSRYREAFGLLASGQ 333 >5VM2-A nrPDB Length = 347 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 73/340 (21%), Positives = 126/340 (37%), Gaps = 22/340 (6%) Query: 14 AARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLH-QTKNDLGMSNYP---MVPGH 69 A G + + + ++V I++ GIC +D+H P + GH Sbjct: 6 AILQVPGTMKIISAEIPVPKEDEVLIKVEYVGICGSDVHGFESGPFIPPKDPNQEIGLGH 65 Query: 70 EVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQ 129 E G VV VGS V KF GD V + V CG C C CP D Sbjct: 66 ECAGTVVAVGSRVRKFKPGDRVNIEPGVP-CGHCRYCLEGKYNICPDV-----DFMATQP 119 Query: 130 PTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGL 189 +G + F K+P+ M + + A V +++ + +PG + ILG Sbjct: 120 NYRGALTHYLCHPESFTYKLPDNMDTMEGTLVEPAAVGMHAAM--LADVKPGKKIIILGA 177 Query: 190 GGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQA---KMSELAD--S 244 G +G M ++ K +G + +KR + LGA + G+ + + + + Sbjct: 178 GCIGLMTLQACKCLGATEIAVVDVLEKRLAMAEQLGATVVINGAKEDTIARCQQFTEDMG 237 Query: 245 LDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMK 304 D V +T ++ L+ GK++++G + L + R+V + Sbjct: 238 ADIVFETAGSAVTVKQAPYLVMRGGKIMIVGTVPGASAI--NFLKINREVTIQTVFRYAN 295 Query: 305 ETEEMLEFCKEK--GLSSII-EVVKMDYVNTAFERLEKND 341 +E + S++ + V AFE N Sbjct: 296 RYPVTIEAISSGRFDVKSMVTHIYDYRDVQQAFEESVNNK 335 >4EJ6-A nrPDB Length = 370 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 75/358 (20%), Positives = 136/358 (37%), Gaps = 22/358 (6%) Query: 1 MGIMEAERKTTGWAAR-DPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLG 59 +G ++ A R + G +S + E GP+D+ +++ CGIC TD H + Sbjct: 13 LGTENLYFQSMMKAVRLESVGNISVRNVGIPEPGPDDLLVKVEACGICGTDRHLLHGEFP 72 Query: 60 MSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIW 119 + P+ GHE G VVE GS V G + G CG C C+ C Sbjct: 73 STP-PVTLGHEFCGIVVEAGSAVRDIAPGARI-TGDPNISCGRCPQCQAGRVNLC----- 125 Query: 120 SYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQ 179 ++ G GGFA+ +V +K +IP + A C + + Sbjct: 126 --RNLRAIGIHRDGGFAEYVLVPRKQAFEIPLTLDPVHGA--FCEPLACCLHGVDLSGIK 181 Query: 180 PGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMS 239 G ILG G +G + V++A+ G ++S+ + +++GA V S + Sbjct: 182 AGSTVAILGGGVIGLLTVQLARLAGATTVILSTRQATKRRLAEEVGATATVDPSAGDVVE 241 Query: 240 ELA-------DSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNP--LQFLTPLLML 290 +A +D VI+ V ++ L K G ++++GV+ ++ ++ Sbjct: 242 AIAGPVGLVPGGVDVVIECAGVAETVKQSTRLAKAGGTVVILGVLPQGEKVEIEPFDILF 301 Query: 291 GRKVITGSFIGSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVV 348 + GSFI + + + + ++ A + + V Sbjct: 302 RELRVLGSFINPFVHRRAA-DLVATGAIEIDRMISRRISLDEAPDVISNPAAAGEVKV 358 >4ILK-A nrPDB Length = 359 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 70/329 (21%), Positives = 126/329 (38%), Gaps = 18/329 (5%) Query: 17 DPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVV 76 + LS + +V +++ GIC +D H + + YP V GHE G + Sbjct: 27 EKPNQLSIIEREIPTPSAGEVRVKVKLAGICGSDSHIYRGHNPFAKYPRVIGHEFFGVID 86 Query: 77 EVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFA 136 VG V VG+ V V +V CG C PC C + + G GGF+ Sbjct: 87 AVGEGVESARVGERVAVDPVV-SCGHCYPCSIGKPNVCT-------TLAVLGVHADGGFS 138 Query: 137 KATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMG 196 + VV K KIPE +A + A + T+ + ++ G + G G +G Sbjct: 139 EYAVVPAKNAWKIPEAVADQYAVMIEPF--TIAANVTGHGQPTENDTVLVYGAGPIGLTI 196 Query: 197 VKIAK-AMGHHVTVISSSNKKREEALQDLGADDYVIGSDQ---AKMSELADSLDYVIDTV 252 V++ K +++ +R E ++ GAD + S +E +ID Sbjct: 197 VQVLKGVYNVKNVIVADRIDERLEKAKESGADWAINNSQTPLGESFAEKGIKPTLIIDAA 256 Query: 253 PVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEF 312 L+ ++L +++LMG + P + + + I S + + + ++++ Sbjct: 257 CHPSILKEAVTLASPAARIVLMGFSSEPSEVIQQGITGKELSIFSSRL-NANKFPVVIDW 315 Query: 313 CKEKGLSS---IIEVVKMDYVNTAFERLE 338 + + I +V A E Sbjct: 316 LSKGLIKPEKLITHTFDFQHVADAISLFE 344 >4CPD-A nrPDB Length = 347 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 73/321 (22%), Positives = 123/321 (38%), Gaps = 17/321 (5%) Query: 30 RETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGD 89 R P D +R+ GIC +DLH + + V GHE VG+V VG + GD Sbjct: 21 RLQHPLDALVRVHLAGICGSDLHLYHGKIPVLP-GSVLGHEFVGQVEAVGEGIQDLQPGD 79 Query: 90 IVGVGCLVGCCGGCSPCERDLEQYCPKK-IWSYNDVYINGQPTQGGFAKATVVHQKFVV- 147 V VG CG C C R C + ++ Y ++ N QG A+ V V Sbjct: 80 WV-VGPFHIACGTCPYCRRHQYNLCERGGVYGYGPMFGN---LQGAQAEILRVPFSNVNL 135 Query: 148 -KIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHH 206 K+P ++ E+A T Y L G +PG ++G G VG M +++A+ +G Sbjct: 136 RKLPPNLSPERAIFAGDILSTAYGGLIQ-GQLRPGDSVAVIGAGPVGLMAIEVAQVLGAS 194 Query: 207 VTVISSSNKKREEALQDLGA----DDYVIGSDQAKMSELADSLDYVIDTVPVHHALEPYL 262 + +R E LGA + + + + D V++ V L L Sbjct: 195 KILAIDRIPERLERAASLGAIPINAEQENPVRRVRSETNDEGPDLVLEAVGGAATLSLAL 254 Query: 263 SLLKLDGKLILMGVINNP-LQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSS- 320 +++ G++ +GV N P F ++ + +L L Sbjct: 255 EMVRPGGRVSAVGVDNAPSFPFPLASGLVKDLTFRIGLANVHLYIDAVLALLASGRLQPE 314 Query: 321 --IIEVVKMDYVNTAFERLEK 339 + + ++ +E ++ Sbjct: 315 RIVSHYLPLEEAPRGYELFDR 335 >3UOG-A nrPDB Length = 363 Score = 214 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 79/337 (23%), Positives = 141/337 (41%), Gaps = 22/337 (6%) Query: 21 ILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMS-NYPMVPGHEVVGEVVEVG 79 L + E G D+ +R + + + D + +G+ +P VP ++ G V VG Sbjct: 40 DLKLAERPVPEAGEHDIIVRTLAVSLNYRDKLVLETGMGLDLAFPFVPASDMSGVVEAVG 99 Query: 80 SDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKAT 139 V++F GD V G G P Y G G ++ Sbjct: 100 KSVTRFRPGDRVISTFAPGWLDGLRPGTGRTPAY-----------ETLGGAHPGVLSEYV 148 Query: 140 VVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKI 199 V+ + + V P+ + +A+ L CAG+T + L G + G R + G GGV G++I Sbjct: 149 VLPEGWFVAAPKSLDAAEASTLPCAGLTAWFALVEKGHLRAGDRVVVQGTGGVALFGLQI 208 Query: 200 AKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELAD-----SLDYVIDTVPV 254 AKA G V V SSS +K + LGAD + ++ + + D++++ Sbjct: 209 AKATGAEVIVTSSSREK-LDRAFALGADHGINRLEEDWVERVYALTGDRGADHILEIAGG 267 Query: 255 HHALEPYLSLLKLDGKLILMGVINN-PLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFC 313 L L + DG++ ++GV+ + L+L V+ G +G + E+++ Sbjct: 268 -AGLGQSLKAVAPDGRISVIGVLEGFEVSGPVGPLLLKSPVVQGISVGHRRALEDLVGAV 326 Query: 314 KEKGLSSIIEV-VKMDYVNTAFERLEKNDVRYRFVVD 349 GL +I++ K V A L++ + V++ Sbjct: 327 DRLGLKPVIDMRYKFTEVPEALAHLDRGPF-GKVVIE 362 >4OH1-A nrPDB Length = 351 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 78/354 (22%), Positives = 130/354 (36%), Gaps = 36/354 (10%) Query: 16 RDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLG------MSNYPMVPGH 69 ++ G + + E E++ I+++ IC +D H +LG S PM GH Sbjct: 15 KNTMGTVDMMEAPMPEPKDEEIRIKVVYASICGSDTHILTGNLGEMESTTRSMLPMSFGH 74 Query: 70 EVVGEVVEVGSDVS--KFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYIN 127 E+ G + +VGS F VG V V CG C C C + N Sbjct: 75 ELSGVIDKVGSTAEKMGFKVGQKV-VANYAKYCGCCENCREGKVNLCSNMGYRMN----- 128 Query: 128 GQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGIL 187 GF++ V H + IP+ ++ A + +TV + G I+ Sbjct: 129 ------GFSEYAVYHMSQIFPIPDDADLKDYALVEP--LTVALSSAEQAKISYGKSVAIM 180 Query: 188 GLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQ---AKMSELADS 244 G GG+G M V++A+ G + ++ E + GAD + +++ + ELA Sbjct: 181 GAGGLGMMLVQLARLAGASTITVFDIVPEKLELALENGADYALNSAEEGVAERAIELAGG 240 Query: 245 -LDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPL---LMLGRKVITGSFI 300 D V++ A + L LL DG + + L L +K I G Sbjct: 241 RYDCVLEGTGATAAAKLGLQLLARDGDAVYFAMYGKDPILPVNLQSDLYWDQKHIHGMIQ 300 Query: 301 GSM---KETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVE 351 G+ K + K + + AFE L + V+ ++ Sbjct: 301 GAWQFPKSIRMIPRMDFSKIIQKE---HTLTNYKQAFEDLYSKKYA-KIVIKMD 350 >4UEJ-A nrPDB Length = 346 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 68/292 (23%), Positives = 114/292 (39%), Gaps = 22/292 (7%) Query: 17 DPSGILSPYTYTLRETGP-EDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEV 75 D GI+ + E ++V ++I G+C +DL + G YP+ GHE G + Sbjct: 7 DTDGIVRVAESVIPEIKHQDEVRVKIASSGLCGSDLPRIF-KNGAHYYPITLGHEFSGYI 65 Query: 76 VEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGF 135 VGS V GD V L+ C C C + C K G GGF Sbjct: 66 DAVGSGVDDLHPGDAVACVPLLP-CFTCPECLKGFYSQCAK-------YDFIGSRRDGGF 117 Query: 136 AKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHM 195 A+ VV +K V +P M +E A + +TV H I+G G +G + Sbjct: 118 AEYIVVKRKNVFALPTDMPIEDGAFIEP--ITVGLHAFHLAQGCENKNVIIIGAGTIGLL 175 Query: 196 GVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSD------QAKMSELADSLDYVI 249 ++ A A+G + ++ + GA S+ Q+ + EL + ++ Sbjct: 176 AIQCAVALGAKSVTAIDISSEKLALAKSFGAMQTFNSSEMSAPQMQSVLRELRFN-QLIL 234 Query: 250 DTVPVHHALEPYLSLLKLDGKLILMGVINNPLQF---LTPLLMLGRKVITGS 298 +T V +E + + +L L+G ++ L ++ + GS Sbjct: 235 ETAGVPQTVELAVEIAGPHAQLALVGTLHQDLHLTSATFGKILRKELTVIGS 286 >1YKF-A nrPDB Length = 352 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 71/327 (21%), Positives = 118/327 (36%), Gaps = 22/327 (6%) Query: 28 TLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTV 87 GP D +R + C +D+H + M+ GHE VGEVVEVGS+V F Sbjct: 18 EKPAPGPFDAIVRPLAVAPCTSDIHTVFEGAIGERHNMILGHEAVGEVVEVGSEVKDFKP 77 Query: 88 GDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQK--F 145 GD V V + S +R Q+ + + G F + V+ Sbjct: 78 GDRVVVPAITPDW-RTSEVQRGYHQHSGGMLAGWK----FSNVKDGVFGEFFHVNDADMN 132 Query: 146 VVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGH 205 + +P+ + +E A + T + + + G +LG+G VG M V AK G Sbjct: 133 LAHLPKEIPLEAAVMIPDMMTTGFHG-AELADIELGATVAVLGIGPVGLMAVAGAKLRGA 191 Query: 206 HVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL-----ADSLDYVIDTVPVHHALEP 260 + S +A + GA D V D S++ +D I + Sbjct: 192 GRIIAVGSRPVCVDAAKYYGATDIVNYKDGPIESQIMNLTEGKGVDAAIIAGGNADIMAT 251 Query: 261 YLSLLKLDGKLILMGVINNPLQFLTPLLM----LGRKVITGSFI-GSMKETEEMLEFCKE 315 + ++K G + + P L + K I G G E +++ Sbjct: 252 AVKIVKPGGTIANVNYFGEGEVLPVPRLEWGCGMAHKTIKGGLCPGGRLRMERLIDLVFY 311 Query: 316 KGLSS---IIEVVK-MDYVNTAFERLE 338 K + + V + D + AF ++ Sbjct: 312 KRVDPSKLVTHVFRGFDNIEKAFMLMK 338 >3FSR-A nrPDB Length = 352 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 74/327 (22%), Positives = 121/327 (37%), Gaps = 22/327 (6%) Query: 28 TLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTV 87 GP D +R + C +D+H + M+ GHE VGEVVEVGS+V F Sbjct: 18 EKPAPGPFDAIVRPLAVAPCTSDIHTVFEGAIGERHNMILGHEAVGEVVEVGSEVKDFKP 77 Query: 88 GDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQK--F 145 GD V V + S +R Q+ + + G F + V+ Sbjct: 78 GDRVVVPAITPDW-RTSEVQRGYHQHSGGMLAGWK----FSNVKDGVFGEFFHVNDADMN 132 Query: 146 VVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGH 205 + +P+ + +E A + T + + Q G ++G+G VG MG+ AK G Sbjct: 133 LAHLPKEIPLEAAVMIPDMMTTGFHG-AELADIQMGSSVVVIGIGAVGLMGIAGAKLRGA 191 Query: 206 HVTVISSSNKKREEALQDLGADDYVIGS-----DQAKMSELADSLDYVIDTVPVHHALEP 260 + S EA + GA D + DQ +D VI L Sbjct: 192 GRIIGVGSRPICVEAAKFYGATDILNYKNGHIVDQVMKLTNGKGVDRVIMAGGGSETLSQ 251 Query: 261 YLSLLKLDGKLILMGVINNPLQFLTPLLM----LGRKVITGSFI-GSMKETEEMLEFCKE 315 +S++K G + + + L P + + K I G G E +++ Sbjct: 252 AVSMVKPGGIISNINYHGSGDALLIPRVEWGCGMAHKTIKGGLCPGGRLRMERLIDLVFY 311 Query: 316 KGLSS---IIEVVK-MDYVNTAFERLE 338 K + + V + D + AF ++ Sbjct: 312 KRVDPSKLVTHVFRGFDNIEKAFMLMK 338 >6DKH-A nrPDB Length = 346 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 63/305 (20%), Positives = 110/305 (36%), Gaps = 16/305 (5%) Query: 38 NIRIICCGICHTDLHQTKND---LGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVG 94 ++I GIC +DLH + M PMV GHEV+G+V+ SD S+ G V + Sbjct: 34 LVQITRGGICGSDLHYYQEGKVGNFMIKAPMVLGHEVIGKVIH--SDSSELHEGQTVAIN 91 Query: 95 CLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMA 154 CG C C E C + + +Y GGF + +V V P Sbjct: 92 P-SKPCGHCKYCIEHNENQCTDMRFFGSAMYF--PHVDGGFTRYKMVETSQCVPYPAKAD 148 Query: 155 VEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSN 214 + A V +++ H + G R I G+G +G + V K +G V + + Sbjct: 149 EKVMAFAEPLAVAIHAA--HQAGELQGKRVFISGVGPIGCLIVSAVKTLGAAEIVCADVS 206 Query: 215 KKREEALQDLGADDYVIGS--DQAKMSELADSLDYVIDTVPVHHALEPYLSLLKLDGKLI 272 + +++GAD V D D + ++ L + + G ++ Sbjct: 207 PRSLSLGKEMGADVLVNPQNDDMDHWKAEKGYFDVSFEVSGHPSSVNTCLEVTRARGVMV 266 Query: 273 LMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSS---IIEVVKMDY 329 +G+ +F L+ + GS E + + ++ + Sbjct: 267 QVGMGGAMAEFPMMTLIGKEISLRGS-FRFTSEFNTAVSWLANGVINPLPLLSAEYPFTD 325 Query: 330 VNTAF 334 + A Sbjct: 326 LEEAL 330 >3FPL-A nrPDB Length = 351 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 70/329 (21%), Positives = 116/329 (35%), Gaps = 26/329 (7%) Query: 28 TLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTV 87 G D +R + C +D+H M+ GHE VGEVVEVGS+V F Sbjct: 18 ERPVAGSYDAIVRPLAVSPCTSDIHTVFEGALGDRKNMILGHEAVGEVVEVGSEVKDFKP 77 Query: 88 GDIVGVGCLVGCCGGCSPCERDLEQYCPKKI--WSYNDVYINGQPTQGGFAKATVVHQK- 144 GD V V C + +Q+ + W +++ G F + V+ Sbjct: 78 GDRVIVPCTTPDWRSLE-VQAGFQQHSNGMLAGWKFSNFK------DGVFGEYFHVNDAD 130 Query: 145 -FVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAM 203 + +P+ M +E A + T + + + G +LG+G VG M V AK Sbjct: 131 MNLAILPKDMPLENAVMITDMMTTGFHG-AELADIELGATVAVLGIGPVGLMAVAGAKLR 189 Query: 204 GHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL-----ADSLDYVIDTVPVHHAL 258 G + S +A + GA D V D S++ +D I + Sbjct: 190 GAGRIIAVGSRPVCVDAAKYYGATDIVNYKDGPIESQIMNLTEGKGVDAAIIAGGNADIM 249 Query: 259 EPYLSLLKLDGKLILMGVINNPLQFLTPLLM----LGRKVITGSFIGSMKETEEML-EFC 313 + ++K G + + P L + K I G + EML + Sbjct: 250 ATAVKIVKPGGTIANVNYFGEGEVLPVPRLEWGCGMAHKTIKGGLCPGGRLRAEMLRDMV 309 Query: 314 KEKGL---SSIIEVV-KMDYVNTAFERLE 338 + + V D++ A ++ Sbjct: 310 VYNRVDLSKLVTHVYHGFDHIEEALLLMK 338 >3IP1-A nrPDB Length = 404 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 71/346 (20%), Positives = 131/346 (37%), Gaps = 44/346 (12%) Query: 28 TLRET---GPEDVNIRIICCGICHTDLHQTKNDL-------GMSNYPMVPGHEVVGEVVE 77 + E P ++ I++ CGIC +D+H + D G++ +P+ GHE G VVE Sbjct: 46 EVPEPRIEKPTEIIIKVKACGICGSDVHMAQTDEEGYILYPGLTGFPVTLGHEFSGVVVE 105 Query: 78 VGSDV------SKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPT 131 G + +F +G+ V ++ CG C PC +C ++ G Sbjct: 106 AGPEAINRRTNKRFEIGEPVCAEEML-WCGHCRPCAEGFPNHCE-------NLNELGFNV 157 Query: 132 QGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTV-------YSPLSHFGLKQPGLRG 184 G FA+ V K+ + E V + L AG V + + G +PG Sbjct: 158 DGAFAEYVKVDAKYAWSLRELEGVYEGDRLFLAGSLVEPTSVAYNAVIVRGGGIRPGDNV 217 Query: 185 GILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELAD- 243 ILG G +G V I K G ++S ++ R ++LGAD + + + + + D Sbjct: 218 VILGGGPIGLAAVAILKHAGASKVILSEPSEVRRNLAKELGADHVIDPTKENFVEAVLDY 277 Query: 244 ----SLDYVIDTVPVHHALEPYLSLL-----KLDGKLILMGVINNPLQFLTPLLMLGRKV 294 ++ V + P + + ++ + ++ + + + + R Sbjct: 278 TNGLGAKLFLEATGVPQLVWPQIEEVIWRARGINATVAIVARADAKIPLTGEVFQVRRAQ 337 Query: 295 ITGS-FIGSMKETEEMLEFCKEK--GLSSIIEVVKMDYVNTAFERL 337 I GS ++ I + V M+ + +RL Sbjct: 338 IVGSQGHSGHGTFPRVISLMASGMDMTKIISKTVSMEEIPEYIKRL 383 >1KEV-A nrPDB Length = 351 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 73/329 (22%), Positives = 119/329 (36%), Gaps = 26/329 (7%) Query: 28 TLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTV 87 G D +R + C +D+H M+ GHE VGEVVEVGS+V F Sbjct: 18 ERPVAGSYDAIVRPLAVSPCTSDIHTVFEGALGDRKNMILGHEAVGEVVEVGSEVKDFKP 77 Query: 88 GDIVGVGCLVGCCGGCSPCERDLEQYCPKKI--WSYNDVYINGQPTQGGFAKATVVHQK- 144 GD V V C + +Q+ + W +++ G F + V+ Sbjct: 78 GDRVIVPCTTPDWRSLE-VQAGFQQHSNGMLAGWKFSNFK------DGVFGEYFHVNDAD 130 Query: 145 -FVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAM 203 + +P+ M +E A + T + + Q G ++G+G VG MG+ AK Sbjct: 131 MNLAILPKDMPLENAVMITDMMTTGFHG-AELADIQMGSSVVVIGIGAVGLMGIAGAKLR 189 Query: 204 GHHVTVISSSNKKREEALQDLGADDYVIGS-----DQAKMSELADSLDYVIDTVPVHHAL 258 G + S EA + GA D + DQ +D VI L Sbjct: 190 GAGRIIGVGSRPICVEAAKFYGATDILNYKNGHIVDQVMKLTNGKGVDRVIMAGGGSETL 249 Query: 259 EPYLSLLKLDGKLILMGVINNPLQFLTPLLM----LGRKVITGSFIGSMKETEEML-EFC 313 +S++K G + + + L P + + K I G + EML + Sbjct: 250 SQAVSMVKPGGIISNINYHGSGDALLIPRVEWGCGMAHKTIKGGLCPGGRLRAEMLRDMV 309 Query: 314 KEKGL---SSIIEVV-KMDYVNTAFERLE 338 + + V D++ A ++ Sbjct: 310 VYNRVDLSKLVTHVYHGFDHIEEALLLMK 338 >3M6I-A nrPDB Length = 363 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 62/320 (19%), Positives = 109/320 (34%), Gaps = 26/320 (8%) Query: 31 ETGPEDVNIRIICCGICHTDLHQTKNDLGMSNY---PMVPGHEVVGEVVEVGSDVSKFTV 87 E +V + + GIC +D+H K+ V GHE GEV+ V V V Sbjct: 37 ELKEGEVTVAVRSTGICGSDVHFWKHGCIGPMIVECDHVLGHESAGEVIAVHPSVKSIKV 96 Query: 88 GDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVV 147 GD V + V C C PC C + V P G + V H Sbjct: 97 GDRVAIEPQV-ICNACEPCLTGRYNGCER-------VDFLSTPPVPGLLRRYVNHPAVWC 148 Query: 148 KIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHV 207 M+ E A L ++V + G I G G +G + + AKA G Sbjct: 149 HKIGNMSYENGAMLEP--LSVALAGLQRAGVRLGDPVLICGAGPIGLITMLCAKAAGACP 206 Query: 208 TVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSL---------DYVIDTVPVHHAL 258 VI+ ++ R + +++ + ++ E A + ++ V ++ Sbjct: 207 LVITDIDEGRLKFAKEICPEVVTHKVERLSAEESAKKIVESFGGIEPAVALECTGVESSI 266 Query: 259 EPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGL 318 + +K GK+ ++GV N +Q + + + + + + Sbjct: 267 AAAIWAVKFGGKVFVIGVGKNEIQIPFMRASVREVDLQFQY-RYCNTWPRAIRLVENGLV 325 Query: 319 ---SSIIEVVKMDYVNTAFE 335 + ++ AFE Sbjct: 326 DLTRLVTHRFPLEDALKAFE 345 >3FPC-A nrPDB Length = 352 Score = 184 bits (466), Expect = 7e-47, Method: Composition-based stats. Identities = 66/327 (20%), Positives = 119/327 (36%), Gaps = 22/327 (6%) Query: 28 TLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTV 87 GP D +R + C +D+H + M+ GHE VGEVVEVGS+V F Sbjct: 18 EKPAPGPFDAIVRPLAVAPCTSDIHTVFEGAIGERHNMILGHEAVGEVVEVGSEVKDFKP 77 Query: 88 GDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQK--F 145 GD V V + S +R Q+ + + G F + V+ Sbjct: 78 GDRVVVPAITPDW-RTSEVQRGYHQHSGGMLAGWK----FSNVKDGVFGEFFHVNDADMN 132 Query: 146 VVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGH 205 + +P+ + +E A + T + + + G ++G+G VG M V A +G Sbjct: 133 LAHLPKEIPLEAAVMIPDMMTTGFHG-AELANIKLGDTVCVIGIGPVGLMSVAGANHLGA 191 Query: 206 HVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL-----ADSLDYVIDTVPVHHALEP 260 S K + + GA D + + + ++ +D V+ H Sbjct: 192 GRIFAVGSRKHCCDIALEYGATDIINYKNGDIVEQILKATDGKGVDKVVIAGGDVHTFAQ 251 Query: 261 YLSLLKLDGKLILMGVINNPLQFLTPL----LMLGRKVITGSFI-GSMKETEEMLEFCKE 315 + ++K + + + P + +G K I G G E +++ Sbjct: 252 AVKMIKPGSDIGNVNYLGEGDNIDIPRSEWGVGMGHKHIHGGLCPGGRLRMERLIDLVFY 311 Query: 316 KGLSS---IIEVVK-MDYVNTAFERLE 338 K + + V + D + AF ++ Sbjct: 312 KRVDPSKLVTHVFRGFDNIEKAFMLMK 338 >4Y1B-A nrPDB Length = 425 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 59/368 (16%), Positives = 123/368 (33%), Gaps = 53/368 (14%) Query: 18 PSGILSPYTYTLRETGPEDVNIRIICCGICHT----------DLHQTKNDLGMSNYPMVP 67 P + GP V ++++ G+ + D+ + G + + Sbjct: 54 PVDAFRTEVVDVPPVGPGQVLVKVMAAGVNYNNVWAALGEPLDVIAARQKQGATEDFHIG 113 Query: 68 GHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYIN 127 G ++ G V VG V ++V + C D +++W Y + Y Sbjct: 114 GSDLSGIVWAVGDGVRLKPGAEVVVLACRWDESAQDIRLGADPVTSSTQRVWGYEENY-- 171 Query: 128 GQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFG--LKQPGLRGG 185 G FA+ VV + P+ ++ A+ + T Y L + +PG Sbjct: 172 -----GSFAQFAVVDEYMCHPKPQRLSWAAASCYMATAATAYRQLFGWEPHTVRPGDPVL 226 Query: 186 IL-GLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADS 244 I G GG+G + +++ + +G + V S+++R E LGA ++ + L D+ Sbjct: 227 IWGGAGGLGSIAIQLVRHVG-GIPVAVVSSEERGEFCMRLGAKGWIDRREFDHWGRLPDT 285 Query: 245 LD-----------------------------YVIDTVPVHHALEPYLSLLKLDGKLILM- 274 D V++ + + + G +++ Sbjct: 286 TDEEAMKQWLDGARAFGRRFWEVLGERRAPRIVLEHSGAD-TIPTSIYMADNAGMVVICG 344 Query: 275 GVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSSII-EVVKMDYVNTA 333 G L + +K + GS S +E E+ + + + + + A Sbjct: 345 GTTGYNGDVDLRFLWMRQKRLQGSHAASAREAREITRLIDQGAIDPCLSRTFGFEEIGLA 404 Query: 334 FERLEKND 341 + + N Sbjct: 405 HQLIHDNQ 412 >2OUI-A nrPDB Length = 360 Score = 167 bits (423), Expect = 6e-42, Method: Composition-based stats. Identities = 64/327 (19%), Positives = 115/327 (35%), Gaps = 22/327 (6%) Query: 29 LRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVG 88 + E GP D +R + C +D H + M+ GHE VG++V+VGS V + VG Sbjct: 19 IPECGPLDALVRPLALAPCTSDTHTVWAGAIGDRHDMILGHEAVGQIVKVGSLVKRLKVG 78 Query: 89 DIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQ--KFV 146 D V V + G +R + + + G F++ V++ + Sbjct: 79 DKVIVPAITPDWGE-EESQRGYPMHSGGMLGGWK----FSNFKDGVFSEVFHVNEADANL 133 Query: 147 VKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHH 206 +P + E A L VT + + G ++G+G VG M V A +G Sbjct: 134 ALLPRDIKPEDAVMLSD-MVTTGFHGAELANIKLGDTVCVIGIGPVGLMSVAGANHLGAG 192 Query: 207 VTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL-----ADSLDYVIDTVPVHHALEPY 261 S K + + GA D + + + ++ +D V+ H Sbjct: 193 RIFAVGSRKHCCDIALEYGATDIINYKNGDIVEQILKATDGKGVDKVVIAGGDVHTFAQA 252 Query: 262 LSLLKLDGKLILMGVINNPLQFLTPL----LMLGRKVITGSFI-GSMKETEEMLEFCKEK 316 + ++K + + + P + +G K I G G E++ Sbjct: 253 VKMIKPGSDIGNVNYLGEGDNIPIPRSEWGVGMGHKHIHGGLTPGGRVRMEKLASLISTG 312 Query: 317 GL---SSIIEVV-KMDYVNTAFERLEK 339 L I ++ V A ++ Sbjct: 313 KLDTSKLITHRFEGLEKVEDALMLMKN 339 >3FBG-A nrPDB Length = 346 Score = 167 bits (422), Expect = 8e-42, Method: Composition-based stats. Identities = 74/359 (20%), Positives = 136/359 (37%), Gaps = 65/359 (18%) Query: 19 SGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEV 78 + + + E ++ ++I + D Q D +S P V G + +G V V Sbjct: 17 GNLFKTFNLDIPEPKVHEILVKIQSISVNPVDTKQRLMD--VSKAPRVLGFDAIGVVESV 74 Query: 79 GSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQ-GGFAK 137 G++V+ F GDIV Y +G P Q G A+ Sbjct: 75 GNEVTMFNQGDIV---------------------------------YYSGSPDQNGSNAE 101 Query: 138 ATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPL-------SHFGLKQPGLRGGILGLG 190 +++++ V K P+ ++ EQA L G+T Y L + + I G G Sbjct: 102 YQLINERLVAKAPKNISAEQAVSLPLTGITAYETLFDVFGISRNRNENEGKTLLIINGAG 161 Query: 191 GVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADS---LDY 247 GVG + +IAKA G V +S N+ E + +GAD + + +DY Sbjct: 162 GVGSIATQIAKAYGLRVITTASRNETIEWT-KKMGADIVLNHKESLLNQFKTQGIELVDY 220 Query: 248 VIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLT--PLLMLGRKVITGSFIGSMKE 305 V T + + L+K G + + N P + F + + Sbjct: 221 VFCTFNTDMYYDDMIQLVKPRGHIATIVAFENDQDLNALKPKSLSFSHEFM--FARPLNQ 278 Query: 306 TEEMLEFCK---------EKGL-----SSIIEVVKMDYVNTAFERLEKNDVRYRFVVDV 350 T++M++ + E+ + + +IE + + + A + LE N + + V+++ Sbjct: 279 TDDMIKHHEYLEDITNKVEQNIYQPTTTKVIEGLTTENIYQAHQILESNTMIGKLVINL 337 >3TQH-A nrPDB Length = 321 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 72/350 (20%), Positives = 132/350 (37%), Gaps = 41/350 (11%) Query: 7 ERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSN---- 62 E K + P +L E + I++ + D ++ Sbjct: 6 EMKAIQFDQFGPPKVLKLVDTPTPEYRKNQMLIKVHAASLNPIDYKTRNGSGFVAKKLKN 65 Query: 63 -YPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSY 121 P G++ GEV+E+GSDV+ +GD V C Sbjct: 66 NLPSGLGYDFSGEVIELGSDVNNVNIGDKVMGIAGFPDHPCC------------------ 107 Query: 122 NDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPG 181 +A+ +++ E ++ QAA L AG+T L+ +KQ Sbjct: 108 -------------YAEYVCASPDTIIQKLEKLSFLQAASLPTAGLTALQALNQAEVKQGD 154 Query: 182 LRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL 241 + G GGVGH+ +++AK G TVI++++K+ L+ LGA+ + ++ + + Sbjct: 155 VVLIHAGAGGVGHLAIQLAKQKG--TTVITTASKRNHAFLKALGAEQCINYHEEDFLLAI 212 Query: 242 ADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIG 301 + +D VID V + + LK G ++ + + + R+ Sbjct: 213 STPVDAVIDLVGGDVGI-QSIDCLKETGCIVSV-PTITAGRVIEVAKQKHRRAFGLLKQF 270 Query: 302 SMKETEEMLEFCKEKGLSSII-EVVKMDYVNTAFERLEKNDVRYRFVVDV 350 +++E + + E L I + ++ TA E LE VR + V V Sbjct: 271 NIEELHYLGKLVSEDKLRIEISRIFQLSEAVTAHELLETGHVRGKLVFKV 320 >4A27-A nrPDB Length = 349 Score = 161 bits (407), Expect = 5e-40, Method: Composition-based stats. Identities = 71/380 (18%), Positives = 137/380 (36%), Gaps = 70/380 (18%) Query: 7 ERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDL-GMSNYPM 65 E + A L + + E ++ IR+ CG+ DL + ++ P+ Sbjct: 3 EMRAVVLAGFGGLNKLRLFRKAMPEPQDGELKIRVKACGLNFIDLMVRQGNIDNPPKTPL 62 Query: 66 VPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVY 125 VPG E G V +G V + +GD V Sbjct: 63 VPGFECSGIVEALGDSVKGYEIGDRVM--------------------------------- 89 Query: 126 INGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGG 185 +A+ +FV KIP+ M+ +AA VT Y L + G+ Sbjct: 90 --AFVNYNAWAEVVCTPVEFVYKIPDDMSFSEAAAFPMNFVTAYVMLFEVANLREGMSVL 147 Query: 186 I-LGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL--A 242 + GGVG ++ + +VTV +++ + EA++D + +D + + A Sbjct: 148 VHSAGGGVGQAVAQLCSTV-PNVTVFGTASTFKHEAIKDSVTHLFDRNADYVQEVKRISA 206 Query: 243 DSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVIN----------------------NP 280 + +D V+D + + + LSLLK G IL G N NP Sbjct: 207 EGVDIVLDCLCGDNTGK-GLSLLKPLGTYILYGSSNMVTGETKSFFSFAKSWWQVEKVNP 265 Query: 281 LQFLTPLLMLGRKVITGSFIGSMKE------TEEMLEFCKEKGLSSIIEVV-KMDYVNTA 333 ++ ++ + + E+++ +K + +++ + ++ V A Sbjct: 266 IKLYEENKVIAGFSLLNLLFKQGRAGLIRGVVEKLIGLYNQKKIKPVVDSLWALEEVKEA 325 Query: 334 FERLEKNDVRYRFVVDVEGS 353 +R+ + ++DVE + Sbjct: 326 MQRIHDRGNIGKLILDVEKT 345 >2VCY-A nrPDB Length = 344 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 61/294 (20%), Positives = 110/294 (37%), Gaps = 48/294 (16%) Query: 16 RDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGM-SNYPMVPGHEVVGE 74 DP+ ++ L DV ++++ I +D++ + + G+ P V G+E V + Sbjct: 23 GDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGLLPELPAVGGNEGVAQ 82 Query: 75 VVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGG 134 VV VGS+V+ GD V I G Sbjct: 83 VVAVGSNVTGLKPGDWV----------------------------------IPANAGLGT 108 Query: 135 FAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGL-GGVG 193 + V ++ ++++P + ++ AA L T Y L F QPG GVG Sbjct: 109 WRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVG 168 Query: 194 HMGVKIAKAMGHHVTVISSSNK---KREEALQDLGADDYVIGSDQAKMSELADSLD---- 246 ++IA A+G + K + L+ LGA ++VI ++ + E+ + Sbjct: 169 QAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGA-EHVITEEELRRPEMKNFFKDMPQ 227 Query: 247 --YVIDTVPVHHALEPYLSLLKLDGKLILM-GVINNPLQFLTPLLMLGRKVITG 297 ++ V + E L L G ++ G+ P+ LL+ + G Sbjct: 228 PRLALNCVGGKSSTE-LLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRG 280 >2OBY-A nrPDB Length = 338 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 64/355 (18%), Positives = 127/355 (35%), Gaps = 61/355 (17%) Query: 20 GILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDL-GMSNYPMVPGHEVVGEVVEV 78 L G +V +++ + DL Q + + G E G V E+ Sbjct: 19 ENLYVKEVAKPSPGEGEVLLKVAASALNRADLMQRQGQYDPPPGASNILGLEASGHVAEL 78 Query: 79 GSDVSK-FTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAK 137 G + +GD GG A+ Sbjct: 79 GPGCQGHWKIGDTAM-----------------------------------ALLPGGGQAQ 103 Query: 138 ATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGI-LGLGGVGHMG 196 V + ++ IPEG+ + QAA + A +T + L G Q G I GL GVG Sbjct: 104 YVTVPEGLLMPIPEGLTLTQAAAIPEAWLTAFQLLHLVGNVQAGDYVLIHAGLSGVGTAA 163 Query: 197 VKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL-----ADSLDYVIDT 251 +++ + G + ++++ ++K+ + + LGA + ++ ++D Sbjct: 164 IQLTRMAGA-IPLVTAGSQKKLQMAEKLGAAAGFNYKKEDFSEATLKFTKGAGVNLILDC 222 Query: 252 VPVHHALEPYLSLLKLDGKLILMGVINNPLQF--LTPLLMLGRKVITGSFIGSMKE---- 305 + + E ++ L LDG+ +L G++ L L+ R + S + S Sbjct: 223 IGGSY-WEKNVNCLALDGRWVLYGLMGGGDINGPLFSKLLFKRGSLITSLLRSRDNKYKQ 281 Query: 306 ------TEEMLEFCKEKGLSSIIEVV----KMDYVNTAFERLEKNDVRYRFVVDV 350 TE++L +G ++ V+ + + A + +E N + V+++ Sbjct: 282 MLVNAFTEQILPHFSTEGPQRLLPVLDRIYPVTEIQEAHKYMEANKNIGKIVLEL 336 >2VN8-A nrPDB Length = 375 Score = 157 bits (398), Expect = 6e-39, Method: Composition-based stats. Identities = 75/399 (18%), Positives = 130/399 (32%), Gaps = 86/399 (21%) Query: 1 MGIMEAERKTTGWAARDPSGILSPY---TYTLRETG-PEDVNIRIICCGICHTDLHQTKN 56 +G ++ W + P +V +++ + D++ Sbjct: 13 LGTENLYFQSMAWVIDKYGKNEVLRFTQNMMMPIIHYPNEVIVKVHAASVNPIDVNMRSG 72 Query: 57 ---------------DLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIV--GVGCLVGC 99 + +P+ G +V G V+E G DV F GD V V Sbjct: 73 YGATALNMKRDPLHVKIKGEEFPLTLGRDVSGVVMECGLDVKYFKPGDEVWAAVPPW--- 129 Query: 100 CGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAA 159 QG ++ VV V P+ + QAA Sbjct: 130 -------------------------------KQGTLSEFVVVSGNEVSHKPKSLTHTQAA 158 Query: 160 PLLCAGVTVYSPLSHFG----LKQPGLRGGILGL-GGVGHMGVKIAKAMGHHVTVISSSN 214 L +T +S ++ G G R ILG GGVG +++ KA HVT + S + Sbjct: 159 SLPYVALTAWSAINKVGGLNDKNCTGKRVLILGASGGVGTFAIQVMKAWDAHVTAVCSQD 218 Query: 215 KKREEALQDLGADDYVIGSDQAKMSELA--DSLDYVIDTVPVHHALEPYLSLLKLDGKLI 272 E ++ LGADD + + +L D+++D V LK Sbjct: 219 AS--ELVRKLGADDVIDYKSGSVEEQLKSLKPFDFILDNVGG-STETWAPDFLKKWSGAT 275 Query: 273 LMGVINNPLQFLTPLLMLGRKVITGSFIGSMK--------------------ETEEMLEF 312 + ++ L + L + + TG +GS +++ E Sbjct: 276 YVTLVTPFLLNMDRLGIADGMLQTGVTVGSKALKHFWKGVHYRWAFFMASGPCLDDIAEL 335 Query: 313 CKEKGLSSIIE-VVKMDYVNTAFERLEKNDVRYRFVVDV 350 + +IE V AF ++E+ R + V++V Sbjct: 336 VDAGKIRPVIEQTFPFSKVPEAFLKVERGHARGKTVINV 374 >3JYN-A nrPDB Length = 325 Score = 154 bits (388), Expect = 7e-38, Method: Composition-based stats. Identities = 65/346 (18%), Positives = 120/346 (34%), Gaps = 53/346 (15%) Query: 20 GILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVG 79 +L + GP+ V +R G+ D + P G E G V VG Sbjct: 14 EVLEYVDFEPEAPGPQAVVVRNKAIGLNFIDTYYRSGLYPAPFLPSGLGAEGAGVVEAVG 73 Query: 80 SDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKAT 139 +V++F VGD V G G +++ Sbjct: 74 DEVTRFKVGDRVAY----------------------------------GTGPLGAYSEVH 99 Query: 140 VVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGG-ILGLGGVGHMGVK 198 V+ + +VK+ + ++ EQAA L+ G+TV L +PG GGVG + + Sbjct: 100 VLPEANLVKLADSVSFEQAAALMLKGLTVQYLLRQTYQVKPGEIILFHAAAGGVGSLACQ 159 Query: 199 IAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLD-----YVIDTVP 253 AKA+G + + S+ ++ + LGA + + S + + + D V D V Sbjct: 160 WAKALGA-KLIGTVSSPEKAAHAKALGAWETIDYSHEDVAKRVLELTDGKKCPVVYDGVG 218 Query: 254 VHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVI------TGSFIGSMKETE 307 L + G ++ G + P+ + ++ + + GS+ + + + Sbjct: 219 -QDTWLTSLDSVAPRGLVVSFGNASGPVSGVNLGILAQKDSVYVTRPTLGSYANNAQNLQ 277 Query: 308 ----EMLEFCKEKGLSSI-IEVVKMDYVNTAFERLEKNDVRYRFVV 348 E+ + L IE + A L ++ Sbjct: 278 TMADELFDMLASGKLKVDGIEQYALKDAAKAQIELSARRTTGSTIL 323 >4J6F-A nrPDB Length = 382 Score = 150 bits (380), Expect = 6e-37, Method: Composition-based stats. Identities = 66/348 (18%), Positives = 127/348 (36%), Gaps = 44/348 (12%) Query: 25 YTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMS----------------NYPMVPG 68 + +V I++ CG+ +TD+ + G +P + G Sbjct: 52 RDVPVPAPAAGEVLIKVTACGMNNTDVWVREGAYGTEDDPSAVSTWRRHGNTLTFPRIQG 111 Query: 69 HEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYING 128 + VG +V VG V + +G+ V V + + S D+ G Sbjct: 112 TDTVGHIVAVGEGVDRARIGERVMVDFSIY----------------NRDDDSLADIDYMG 155 Query: 129 QPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILG 188 GG+A+ + + + + + A CA +T L G + G Sbjct: 156 HGRDGGYAEYMALPAENAHVVATDLTDIELATFCCAYLTGERML-ERARLAAGETVLVTG 214 Query: 189 L-GGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIG-----SDQAKMSELA 242 GGVG +++A+A G ++ +E A+ D+GA V ++ + + Sbjct: 215 ASGGVGSAIIQLARARGAVPIAVAG--PGKEAAMLDIGAQAVVTRGQGDLAEAVEAASGG 272 Query: 243 DSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNP-LQFLTPLLMLGRKVITGSFIG 301 +D V D V L +L+ +G+ G I P +Q + L + + GS G Sbjct: 273 RPIDVVADLVGGP-LFNDLLKILRPEGRYTTAGAIAGPVVQLDLRTMYLKQLELHGSSQG 331 Query: 302 SMKETEEMLEFCKEKGLSSII-EVVKMDYVNTAFERLEKNDVRYRFVV 348 S + ++ + +EK + ++ V + + A + + VV Sbjct: 332 SRADFRRLVRYIEEKKIRPLVGGVYPLSEFHRAQTDFMAKNFVGKLVV 379 >1YB5-A nrPDB Length = 351 Score = 147 bits (372), Expect = 5e-36, Method: Composition-based stats. Identities = 64/329 (19%), Positives = 113/329 (34%), Gaps = 51/329 (15%) Query: 26 TYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNY-PMVPGHEVVGEVVEVGSDVSK 84 + V I++ CG+ + + P PG +V G + VG + S Sbjct: 49 DIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASA 108 Query: 85 FTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQK 144 F GD V GG+A+ + Sbjct: 109 FKKGDRV----------------------------------FTSSTISGGYAEYALAADH 134 Query: 145 FVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGL-GGVGHMGVKIAKAM 203 V K+PE + +Q A + T Y L H + G + G GGVG +IA+A Sbjct: 135 TVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAY 194 Query: 204 GHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELA-----DSLDYVIDTVPVHHAL 258 G + + + + ++ LQ+ GA + + + ++ +D +I+ + L Sbjct: 195 GLKILGTAGTEEGQKIVLQN-GAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANV-NL 252 Query: 259 EPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITG-SFIGSMKETEEMLEFCKE-- 315 LSLL G++I++G ++ M I G + S KE + + Sbjct: 253 SKDLSLLSHGGRVIVVGSRGT-IEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAG 311 Query: 316 ---KGLSSIIEV-VKMDYVNTAFERLEKN 340 L +I ++ V A E + Sbjct: 312 MEIGWLKPVIGSQYPLEKVAEAHENIIHG 340 >4IDE-A nrPDB Length = 332 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 69/329 (20%), Positives = 128/329 (38%), Gaps = 49/329 (14%) Query: 26 TYTLRETGPEDVNIRIICCGICHTDLHQTKN--DLGMSNYPMVPGHEVVGEVVEVGSDVS 83 + + E + V I+++ + D + S P +PG++V G VV+VGS V+ Sbjct: 44 SVAVPEIKEDQVLIKVVAASLNPVDFKRALGYFKDTDSPLPTIPGYDVAGVVVKVGSQVT 103 Query: 84 KFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQ 143 KF VGD V N+ + G A+ T + Sbjct: 104 KFKVGDEV--------------------------YGDLNETALVNPTRFGSLAEYTAADE 137 Query: 144 KFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAM 203 + + P+ ++ +AA L A T + L L + G GGVG +++AK + Sbjct: 138 RVLAHKPKNLSFIEAASLPLAIETAHEGLERAELSAGKSVLVLGGAGGVGTHIIQLAKHV 197 Query: 204 GHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDYVIDTVPVHHALEPYLS 263 V ++++ K+ + L+ LGAD + + + +L + D V D V + + Sbjct: 198 FGASKVAATASTKKLDLLRTLGADLAIDYTKE-NFEDLPEKFDVVYDAVGET---DKAVK 253 Query: 264 LLKLDGKLI-LMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSSII 322 +K GK++ ++G P +L GS E++ + + + ++ Sbjct: 254 AVKEGGKVVTIVGPATPPA-------ILFVLTSKGSV------LEKLKPYLESGKVKPVL 300 Query: 323 E---VVKMDYVNTAFERLEKNDVRYRFVV 348 + V AF LE + + VV Sbjct: 301 DPTSPYPFTKVVEAFGYLESSRATGKVVV 329 >1QOR-A nrPDB Length = 327 Score = 139 bits (351), Expect = 1e-33, Method: Composition-based stats. Identities = 61/348 (17%), Positives = 109/348 (31%), Gaps = 63/348 (18%) Query: 20 GILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVG 79 +L +T + ++ + GI D + + P G E G V +VG Sbjct: 14 EVLQAVEFTPADPAENEIQVENKAIGINFIDTYIRSGLYPPPSLPSGLGTEAAGIVSKVG 73 Query: 80 SDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKAT 139 S V GD V Q G ++ Sbjct: 74 SGVKHIKAGDRVVYA----------------------------------QSALGAYSSVH 99 Query: 140 VVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLR-GGILGLGGVGHMGVK 198 + +P ++ EQAA G+TVY L +P + GGVG + + Sbjct: 100 NIIADKAAILPAAISFEQAAASFLKGLTVYYLLRKTYEIKPDEQFLFHAAAGGVGLIACQ 159 Query: 199 IAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQA---KMSELADS--LDYVIDTVP 253 AKA+G + + +K + AL+ GA + ++ ++ E+ + V D+V Sbjct: 160 WAKALGAKLIGTVGTAQKAQSALKA-GAWQVINYREEDLVERLKEITGGKKVRVVYDSVG 218 Query: 254 VHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETE------ 307 E L L+ G ++ G + + + LG GS + + Sbjct: 219 RD-TWERSLDCLQRRGLMVSFGNSSGAVTGVN----LGILNQKGSLYVTRPSLQGYITTR 273 Query: 308 --------EMLEFCKEKGLSSII---EVVKMDYVNTAFERLEKNDVRY 344 E+ + + + + A E LE + Sbjct: 274 EELTEASNELFSLIASGVIKVDVAEQQKYPLKDAQRAHEILESRATQG 321 >5A3V-A nrPDB Length = 329 Score = 138 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 75/345 (21%), Positives = 124/345 (35%), Gaps = 54/345 (15%) Query: 22 LSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKN---DLGMSNYPMVPGHEVVGEVVEV 78 L + +V +++ + D K +P +P +V GEVVEV Sbjct: 21 LEHVQVPVPTPKSNEVCLKLEATSLNPVDWKIQKGMIRPFLPRKFPCIPATDVAGEVVEV 80 Query: 79 GSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKA 138 GS V F GD V + GG A+ Sbjct: 81 GSGVKNFKAGDKVV--------------------------------AVLSHLGGGGLAEF 108 Query: 139 TVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFG---LKQPGLRGGIL---GLGGV 192 V +K VK P+ + +AA L AG+T L++ L G + IL GGV Sbjct: 109 AVATEKLTVKRPQEVGAAEAAALPVAGLTALQALTNPAGLKLDGTGKKANILVTAASGGV 168 Query: 193 GHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQA---KMSELADSLDYVI 249 GH V++AK HVT + E ++ LGAD+ + S D V+ Sbjct: 169 GHYAVQLAKLANAHVTATCG--ARNIEFVKSLGADEVLDYKTPEGAALKSPSGKKYDAVV 226 Query: 250 DTVPVH--HALEPYLSLLKLDGKLILMGVINNPLQ--FLTPLLMLGRKVITGSFIGSMKE 305 EP LS +GK+I + N + + + M ++++ I + Sbjct: 227 HCANGIPFSVFEPNLS---ENGKVIDITPGPNAMWTYAVKKITMSKKQLVPLLLIPKAEN 283 Query: 306 TEEMLEFCKEKGLSSIIEV-VKMDYVNTAFERLEKNDVRYRFVVD 349 E M+ KE + ++I+ + A+ + + +V+ Sbjct: 284 LEFMVNLVKEGKVKTVIDSKHPLSKAEDAWAKSIDGHATGKIIVE 328 >4A10-A nrPDB Length = 447 Score = 138 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 61/374 (16%), Positives = 114/374 (30%), Gaps = 55/374 (14%) Query: 5 EAERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDL------------- 51 E G A +D L + E P++V + ++ I + + Sbjct: 33 EDADMFKGVADKDVRKSLRLGEVPMPELAPDEVLVAVMASSINYNTVWSAMFEPIPTFHF 92 Query: 52 ---HQTKNDLGM--SNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPC 106 + + V G + G VV G V ++ GD V V Sbjct: 93 LKQNARQGGWATRHDQPYHVLGSDCSGVVVRTGIGVRRWKPGDHVIVHPA--------HV 144 Query: 107 ERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGV 166 + + + GG A+ VV ++ P + E+AA Sbjct: 145 DEQEPATHGDGMLGTEQRAWGFETNFGGLAEYGVVRASQLLPKPAHLTWEEAAVSPLCAG 204 Query: 167 TVYSPLS--HFGLKQPGLRGGILGL-GGVGHMGVKIAKAMGHHVTVISSSNKKREEALQD 223 T Y L + G I G GG+G ++ K G + V S+ ++E A++ Sbjct: 205 TAYRMLVSDRGAQMKQGDIVLIWGASGGLGSYAIQFVKN-GGGIPVAVVSSAQKEAAVRA 263 Query: 224 LGADDYVIGSD----------------------QAKMSELADSLDYVIDTVPVHHALEPY 261 LG D + ++ + + + D V + Sbjct: 264 LGCDLVINRAELGITDDIADDPRRVVETGRKLAKLVVEKAGREPDIVFEHTG-RVTFGLS 322 Query: 262 LSLLKLDGKLILMGVINNPLQ-FLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSS 320 + + + G ++ G + L F L + K I GS + +E + + + Sbjct: 323 VIVARRGGTVVTCGSSSGYLHTFDNRYLWMKLKKIVGSHGANHEEQQATNRLFESGAVVP 382 Query: 321 -IIEVVKMDYVNTA 333 + V + A Sbjct: 383 AMSAVYPLAEAAEA 396 >1WLY-A nrPDB Length = 333 Score = 136 bits (342), Expect = 1e-32, Method: Composition-based stats. Identities = 66/350 (18%), Positives = 122/350 (34%), Gaps = 65/350 (18%) Query: 25 YTYTLRETGPEDVNIRIICCGICHTDLHQTKN---DLGMSNYPMVPGHEVVGEVVEVGSD 81 + GP V +R G+ D + L + P+V G E V EVG Sbjct: 19 EEVKVGSPGPGQVRLRNTAIGVNFLDTYHRAGIPHPLVVGEPPIVVGFEAAAVVEEVGPG 78 Query: 82 VSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVV 141 V+ FTVG+ V P G +++ + Sbjct: 79 VTDFTVGERV----------------------------------CTCLPPLGAYSQERLY 104 Query: 142 HQKFVVKIPEGMAVEQA--APLLCAGVTVYSPLSHFGLKQPGLRGGI-LGLGGVGHMGVK 198 + ++K+P+ + ++ A L+ G+T L +PG I GG+GH+ V Sbjct: 105 PAEKLIKVPKDLDLDDVHLAGLMLKGMTAQYLLHQTHKVKPGDYVLIHAAAGGMGHIMVP 164 Query: 199 IAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQA---KMSELAD--SLDYVIDTVP 253 A+ +G V + + S +++ E + LG + S Q + E+ +D V D++ Sbjct: 165 WARHLGATV-IGTVSTEEKAETARKLGCHHTINYSTQDFAEVVREITGGKGVDVVYDSIG 223 Query: 254 VHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFI----------GSM 303 L+ L L+ G G + P+ ++ + GS + Sbjct: 224 KD-TLQKSLDCLRPRGMCAAYGHASG---VADPIRVVEDLGVRGSLFITRPALWHYMSNR 279 Query: 304 KETEE----MLEFCKEKGLSSII-EVVKMDYVNTAFERLEKNDVRYRFVV 348 E +E + + K L S + + + A + + V+ Sbjct: 280 SEIDEGSKCLFDAVKAGVLHSSVAKTFPLREAAAAHKYMGGRQTIGSIVL 329 >3HZZ-A nrPDB Length = 467 Score = 135 bits (340), Expect = 3e-32, Method: Composition-based stats. Identities = 60/380 (15%), Positives = 125/380 (32%), Gaps = 67/380 (17%) Query: 16 RDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDL----------------------HQ 53 +DP + + E GP + + ++ + + + Sbjct: 70 KDPRKSIHLDEVPVPELGPGEALVAVMASSVNYNSVWTSIFEPVSTFAFLERYGKLSPLT 129 Query: 54 TKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQY 113 ++DL + G ++ G V+ G V+ + GD V CL P D Sbjct: 130 KRHDLPY----HIIGSDLAGVVLRTGPGVNAWQPGDEVVAHCLSVELES--PDGHDDTML 183 Query: 114 CPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPL- 172 P++ + GG A+ +V ++ P+ + E+AA T Y L Sbjct: 184 DPEQRIWGFETNF------GGLAEIALVKTNQLMPKPKHLTWEEAAAPGLVNSTAYRQLV 237 Query: 173 -SHFGLKQPGLRGGILGL-GGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYV 230 + + G I G GG+G + A A G + + S+ ++ E + +GA+ + Sbjct: 238 SRNGAAMKQGDNVLIWGASGGLGSYATQFALAGGANP-ICVVSSPQKAEICRSMGAEAII 296 Query: 231 IGSDQ--------------------AKMSELADS--LDYVIDTVPVHHALEPYLSLLKLD 268 + + ++ EL +D V + P + + + Sbjct: 297 DRNAEGYKFWKDEHTQDPKEWKRFGKRIRELTGGEDIDIVFEH-PGRETFGASVYVTRKG 355 Query: 269 GKLILMGVINNPL-QFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSSII-EVVK 326 G + + + ++ L + K I GS + +E E + + + + Sbjct: 356 GTITTCASTSGYMHEYDNRYLWMSLKRIIGSHFANYREAYEANRLIAKGKIHPTLSKTYS 415 Query: 327 MDYVNTA----FERLEKNDV 342 ++ A L + V Sbjct: 416 LEETGQAAYDVHRNLHQGKV 435 >3QWB-A nrPDB Length = 334 Score = 133 bits (336), Expect = 7e-32, Method: Composition-based stats. Identities = 65/350 (18%), Positives = 126/350 (36%), Gaps = 59/350 (16%) Query: 21 ILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGS 80 ++ Y + E++ I+ G+ + + + K P V G E G VV G Sbjct: 22 VIKYEDYPVPSISEEELLIKNKYTGVNYIESYFRKGIYPCEK-PYVLGREASGTVVAKGK 80 Query: 81 DVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKAT- 139 V+ F VGD V + FA+ + Sbjct: 81 GVTNFEVGDQVA------------------------------------YISNSTFAQYSK 104 Query: 140 VVHQKFVVKIPEGMAVEQA---APLLCAGVTVYSPLSHFGLKQPGLRGGILGL-GGVGHM 195 + Q V+K+P+G + E+ A L +T S + + G + GGVG + Sbjct: 105 ISSQGPVMKLPKGTSDEELKLYAAGLLQVLTALSFTNEAYHVKKGDYVLLFAAAGGVGLI 164 Query: 196 GVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL-----ADSLDYVID 250 ++ K G H ++S+++K + ++ GA+ + S + + ++ +D D Sbjct: 165 LNQLLKMKGAHTIAVASTDEK-LKIAKEYGAEYLINASKEDILRQVLKFTNGKGVDASFD 223 Query: 251 TVPVHHALEPYLSLLKLDGKLILMGVINN--PLQFLTPLLMLGRKVITGSFIGSMKE--- 305 +V E L+ LK G + G + P +T L ++ G + + Sbjct: 224 SVGKD-TFEISLAALKRKGVFVSFGNASGLIPPFSITRLSPKNITLVRPQLYGYIADPEE 282 Query: 306 ----TEEMLEFCKEKGLSSII-EVVKMDYVNTAFERLEKNDVRYRFVVDV 350 ++E K L+ I + + TA +E + V+++ Sbjct: 283 WKYYSDEFFGLVNSKKLNIKIYKTYPLRDYRTAAADIESRKTVGKLVLEI 332 >4DVJ-A nrPDB Length = 363 Score = 131 bits (329), Expect = 6e-31, Method: Composition-based stats. Identities = 67/375 (17%), Positives = 121/375 (32%), Gaps = 69/375 (18%) Query: 6 AERKTTGWAARDP-SGILSPYTYTLRETGP--EDVNIRIICCGICHTDLHQTKNDLGMSN 62 K G+ P + S L + P D+ + + + D ++ Sbjct: 21 QSMKAVGYNKPAPITDDASLLDIELPKPAPAGHDILVEVKAVSVNPVDYKVRRSTPPDGT 80 Query: 63 YPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYN 122 V G++ G V VG DV+ F GD V Sbjct: 81 DWKVIGYDAAGIVSAVGPDVTLFRPGDEV------------------------------- 109 Query: 123 DVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLS---HFGLKQ 179 Y G A+ +V ++ V + P+ + +AA L +T + Sbjct: 110 -FYAGSIIRPGTNAEFHLVDERIVGRKPKTLDWAEAAALPLTSITAWEAFFDRLDVNKPV 168 Query: 180 PGLRGGIL---GLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQA 236 PG IL G GGVG + V+IA+ + ++S + +E ++ LGA + S Sbjct: 169 PGAAPAILIVGGAGGVGSIAVQIARQRTDLTVIATASRPETQEWVKSLGAHHVIDHSKPL 228 Query: 237 KMSELADSL---DYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRK 293 A L +V T L+ G+ L+ +++ RK Sbjct: 229 AAEVAALGLGAPAFVFSTTHTDKHAAEIADLIAPQGRFCLI-----DDPSAFDIMLFKRK 283 Query: 294 VITG--------SFIGS--MKE----TEEMLEFCKEKGLSSIIEVVKMDYVN-----TAF 334 ++ G+ M E ++ E L + + ++ +N A Sbjct: 284 AVSIHHELMFTRPMFGTPDMSEQGRLLNDVSRLVDEGRLRTTL-TNRLSPINAANLKQAH 342 Query: 335 ERLEKNDVRYRFVVD 349 +E R + V++ Sbjct: 343 ALVESGTARGKVVIE 357 >4RVS-A nrPDB Length = 329 Score = 128 bits (322), Expect = 4e-30, Method: Composition-based stats. Identities = 66/356 (18%), Positives = 114/356 (32%), Gaps = 69/356 (19%) Query: 20 GILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVG 79 G+L + G ++ I+ G+ D + P V G EV G V VG Sbjct: 14 GVLRHVDQPQPQPGHGELLIKAEAIGVNFIDTYFRSGQYPR-ELPFVIGSEVCGTVEAVG 72 Query: 80 SDVSK----FTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGF 135 V+ +VGD V G + Sbjct: 73 PGVTAADTAISVGDRVVSA-----------------------------------SANGAY 97 Query: 136 AKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGI-LGLGGVGH 194 A+ K+P+ + E AA L G+T + L + G + G GGVG Sbjct: 98 AEFCTAPASLTAKVPDDVTSEVAASALLKGLTAHYLLKSVYPVKRGDTVLVHAGAGGVGL 157 Query: 195 MGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQA-----KMSELAD--SLDY 247 + + A +G + + S ++ + +D GAD + + A ++ EL + Sbjct: 158 ILTQWATHLG-VRVITTVSTAEKAKLSKDAGADVVLDYPEDAWQFAGRVRELTGGTGVQA 216 Query: 248 VIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKET- 306 V D V + L+ L + G L L G + P+ + P R GS + Sbjct: 217 VYDGVGA-TTFDASLASLAVRGTLALFGAASGPVPPVDP----QRLNAAGSVYLTRPSLF 271 Query: 307 -------------EEMLEFCKEKGLSSII-EVVKMDYVNTAFERLEKNDVRYRFVV 348 E+ + + ++ + + A + LE V+ Sbjct: 272 HFTRTGEEFSWRAAELFDAIGNEAITVAVGGRYPLADALRAHQDLEARKTVGSVVL 327 >2DPH-A nrPDB Length = 398 Score = 127 bits (320), Expect = 6e-30, Method: Composition-based stats. Identities = 78/371 (21%), Positives = 135/371 (36%), Gaps = 61/371 (16%) Query: 34 PEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGV 93 V ++++ IC +D H + + V GHE+ GEVVE GSDV +GD+V V Sbjct: 32 EHAVILKVVSTNICGSDQHIYRGRFIVPK-GHVLGHEITGEVVEKGSDVELMDIGDLVSV 90 Query: 94 GCLVGCCGGCSPCERDLEQYCPKKIWS----YNDVYINGQPTQGGFAKATVVH--QKFVV 147 V CG C C+ C + + + + GG A+ +V ++ Sbjct: 91 PFNV-ACGRCRNCKEARSDVCENNLVNPDADLGAFGFDLKGWSGGQAEYVLVPYADYMLL 149 Query: 148 KI-PEGMAVEQA---APLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAM 203 K + A+E+ + T + G +PG I G G VG A+ + Sbjct: 150 KFGDKEQAMEKIKDLTLISDILPTGFHGCVSAG-VKPGSHVYIAGAGPVGRCAAAGARLL 208 Query: 204 GHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELAD------SLDYVIDTVPVHH- 256 G ++ N +R + L D G + + + A + + D +D +D V Sbjct: 209 GAACVIVGDQNPERLKLLSDAG-FETIDLRNSAPLRDQIDQILGKPEVDCGVDAVGFEAH 267 Query: 257 -------------ALEPYLSLLKLDGKL----ILMGVINNPLQFLTP---LLMLGRKVIT 296 AL +++ G + I +G +P+ L + K+ T Sbjct: 268 GLGDEANTETPNGALNSLFDVVRAGGAIGIPGIYVGSDPDPVNKDAGSGRLHLDFGKMWT 327 Query: 297 GS--FIGSMKET-------------EEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKND 341 S + M ++M K IEV+ +D + + +K Sbjct: 328 KSIRIMTGMAPVTNYNRHLTEAILWDQMPYLSK----VMNIEVITLDQAPDGYAKFDKGS 383 Query: 342 VRYRFVVDVEG 352 +FV+D G Sbjct: 384 -PAKFVIDPHG 393 >4JLW-A nrPDB Length = 399 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 78/371 (21%), Positives = 129/371 (34%), Gaps = 54/371 (14%) Query: 35 EDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVG 94 V +R++ IC +D H + +V GHE+ GEVVE+G V +GD+V V Sbjct: 35 HGVILRVVSTNICGSDQHMVRGRTTAPE-GLVLGHEITGEVVEIGRGVETMKIGDLVSVP 93 Query: 95 CLVGCCGGCSPCERDLEQYC-----PKKIWSYNDVYINGQPTQGGFAKATVVH--QKFVV 147 V CG C C+ C + +Y V + G GG A+ +V ++ Sbjct: 94 FNV-ACGHCRTCKEQHTGVCLTVNPARAGGAYGYVDMGGWV--GGQAEYVLVPYADFNLL 150 Query: 148 KIP-EGMAVEQAAPLLCAG---VTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAM 203 K+P A+E+ L C T Y G PG I G G VG A+ + Sbjct: 151 KLPNREAAMEKIRDLTCLSDILPTGYHGAVTAG-VGPGSTVYIAGAGPVGLAAAASARLL 209 Query: 204 GHHVTVISSSNKKREEALQDLG---ADDYVIGSDQAKMSELAD--SLDYVIDTVPVHH-- 256 G V ++ N R + G AD +++ L +D +D V Sbjct: 210 GAAVVIVGDVNPTRLAHAKKQGFEIADLSKDTPLHEQIAALLGEPEVDCAVDAVGFEARG 269 Query: 257 -------------ALEPYLSLLKLDGKLILMGVI-------------NNPLQFLTPLLML 290 L + + ++ GK+ + G+ + L L Sbjct: 270 HGHSGSQQEAPATVLNSLMGITRVAGKIGIPGLYVTEDPGAVDAAAKHGALSIRFGLGWA 329 Query: 291 GRKVITGSFIGSMKETEEMLEFCKEKGLSSI----IEVVKMDYVNTAFERLEKNDVRYRF 346 MK ++++ + +EV+ +D + + V +F Sbjct: 330 KSHSFHTGQTPVMKYNRQLMQAIMWDRIKIADIVGVEVITLDDAPKGYGEFDAG-VPKKF 388 Query: 347 VVDVEGSNLDA 357 V+D A Sbjct: 389 VIDPHNLFRAA 399 >4EYE-A nrPDB Length = 342 Score = 123 bits (308), Expect = 1e-28, Method: Composition-based stats. Identities = 69/371 (18%), Positives = 124/371 (33%), Gaps = 62/371 (16%) Query: 1 MGIMEAERKTTGWA-ARDPSGILSPY-----TYTLRETGPEDVNIRIICCGICHTDLHQT 54 MG +EA+ + G A + P GP V + + G+C D T Sbjct: 9 MGTLEAQTQGPGSMKAIQAQSLSGPEGLVYTDVETPGAGPNVVVVDVKAAGVCFPDYLMT 68 Query: 55 KNDLGMS-NYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQY 113 K + + P VPG E G V S GD V + Sbjct: 69 KGEYQLKMEPPFVPGIETAGVVRSAPEG-SGIKPGDRVMAFNFI---------------- 111 Query: 114 CPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLS 173 GG+A+ V ++ P + +A L+ T+Y + Sbjct: 112 -------------------GGYAERVAVAPSNILPTPPQLDDAEAVALIANYHTMYFAYA 152 Query: 174 HFGLKQPGLRGGIL-GLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIG 232 G + G +L GG+G ++IAK MG V + + E ++ +GAD V+ Sbjct: 153 RRGQLRAGETVLVLGAAGGIGTAAIQIAKGMGAKVIAVVNRTA-ATEFVKSVGAD-IVLP 210 Query: 233 SDQAKMSELAD-----SLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQ-FLTP 286 ++ + + +D V+D + A + + L +G+L+++G + Sbjct: 211 LEEGWAKAVREATGGAGVDMVVDPIGGP-AFDDAVRTLASEGRLLVVGFAAGGIPTIKVN 269 Query: 287 LLMLGRKVITGSFIGSMKETE---------EMLEFCKEKGLSSIIEVVKMDYVNTAFERL 337 L+L + G G T + + E + + + A + Sbjct: 270 RLLLRNASLIGVAWGEFLRTHADYLYETQAGLEKLVAEGMRPPVSARIPLSEGRQALQDF 329 Query: 338 EKNDVRYRFVV 348 V + V+ Sbjct: 330 ADGKVYGKMVL 340 >1KOL-A nrPDB Length = 398 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 62/278 (22%), Positives = 104/278 (37%), Gaps = 32/278 (11%) Query: 34 PEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGV 93 V ++++ IC +D H + + +V GHE+ GEV+E G DV +GD+V V Sbjct: 33 EHGVILKVVSTNICGSDQHMVRGRT-TAQVGLVLGHEITGEVIEKGRDVENLQIGDLVSV 91 Query: 94 GCLVGCCGGCSPCERDLEQYCPK---KIWSYNDVYINGQPTQGGFAKATVVH--QKFVVK 148 V CG C C+ C Y++ GG A+ +V ++K Sbjct: 92 PFNV-ACGRCRSCKEMHTGVCLTVNPARAGGAYGYVDMGDWTGGQAEYVLVPYADFNLLK 150 Query: 149 IPE-GMAVEQAAPLLCAG---VTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMG 204 +P+ A+E+ L C T Y G PG + G G VG A+ +G Sbjct: 151 LPDRDKAMEKIRDLTCLSDILPTGYHGAVTAG-VGPGSTVYVAGAGPVGLAAAASARLLG 209 Query: 205 HHVTVISSSNKKREEALQDLG---ADDYVIGSDQAKMSELAD--SLDYVIDTVPVHH--- 256 V ++ N R + G AD + +++ L +D +D V Sbjct: 210 AAVVIVGDLNPARLAHAKAQGFEIADLSLDTPLHEQIAALLGEPEVDCAVDAVGFEARGH 269 Query: 257 ------------ALEPYLSLLKLDGKLILMGVINNPLQ 282 L + + ++ GK+ + G+ Sbjct: 270 GHEGAKHEAPATVLNSLMQVTRVAGKIGIPGLYVTEDP 307 >2WEK-A nrPDB Length = 341 Score = 115 bits (288), Expect = 3e-26, Method: Composition-based stats. Identities = 65/355 (18%), Positives = 117/355 (32%), Gaps = 73/355 (20%) Query: 28 TLRETGPEDVNIRIICCGICHTDLHQTKNDL-GMSNYPMVPGHEVVGEVVEVG-SDVSKF 85 + G D+ +R G+ +D++ + P G E +GEVV +G S +++ Sbjct: 26 PVPLPGDGDLLVRNRFVGVNASDINYSAGRYDPSVKPPFDIGFEGIGEVVALGLSASARY 85 Query: 86 TVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKF 145 TVG V G FA+ TVV Sbjct: 86 TVGQAVA------------------------------------YMAPGSFAEYTVVPASI 109 Query: 146 VVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGL-GGVGHMGVKIAKAMG 204 +P + LL +G T Y L G G + + GG G ++++K Sbjct: 110 ATPVPSVKP--EYLTLLVSGTTAYISLKELGGLSEGKKVLVTAAAGGTGQFAMQLSKKAK 167 Query: 205 HHVTVISSSNKKREEALQDLGADDYVIGSDQ----AKMSELADSLDYVIDTVPVHHALEP 260 HV SS++K L+ LG D + + E + +D V ++V + Sbjct: 168 CHVIGTCSSDEKS-AFLKSLGCDRPINYKTEPVGTVLKQEYPEGVDVVYESVGG-AMFDL 225 Query: 261 YLSLLKLDGKLILMGV-----------INNPLQFLTPLLMLGRKVITGSFIGSMKETEE- 308 + L G+LI++G L+ + G F+ + Sbjct: 226 AVDALATKGRLIVIGFISGYQTPTGLSPVKAGTLPAK-LLKKSASVQGFFLNHYLSKYQA 284 Query: 309 ----MLEFCKEKGLSSIIEV---------VKMDYVNTAFERLEKNDVRYRFVVDV 350 +LE C L +++ ++ + A + + VV++ Sbjct: 285 AMSHLLEMCVSGDLVCEVDLGDLSPEGRFTGLESIFRAVNYMYMGKNTGKIVVEL 339 >3SLK-A nrPDB Length = 795 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 54/336 (16%), Positives = 103/336 (30%), Gaps = 61/336 (18%) Query: 30 RETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGD 89 G +V I + G+ D G E G VVE G V+ GD Sbjct: 234 APLGDGEVRIAMRAAGVNFRDALIALGMYPGV---ASLGSEGAGVVVETGPGVTGLAPGD 290 Query: 90 IVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKI 149 V F V + V +I Sbjct: 291 RVM------------------------------------GMIPKAFGPLAVADHRMVTRI 314 Query: 150 PEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGI-LGLGGVGHMGVKIAKAMGHHVT 208 P G + +AA + +T Y L +PG + GGVG +++A+ +G V Sbjct: 315 PAGWSFARAASVPIVFLTAYYALVDLAGLRPGESLLVHSAAGGVGMAAIQLARHLGAEVY 374 Query: 209 VISSSNK-KREEALQDLGADDYVIGSDQAKMSELAD-SLDYVIDTVPVHHALEPYLSLLK 266 +S +K + E ++ A +Q + +D V++++ A + L +L Sbjct: 375 ATASEDKWQAVELSREHLASSRTCDFEQQFLGATGGRGVDVVLNSLAGEFA-DASLRMLP 433 Query: 267 LDGKL-----------ILMGVINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKE 315 G+ + + + + + + G E++E + Sbjct: 434 RGGRFLELGKTDVRDPVEVADAHPGVSYQAFDTVEAGPQRIGEM------LHELVELFEG 487 Query: 316 KGLSSI-IEVVKMDYVNTAFERLEKNDVRYRFVVDV 350 + L + + + A L + + V+ + Sbjct: 488 RVLEPLPVTAWDVRQAPEALRHLSQARHVGKLVLTM 523 >3B70-A nrPDB Length = 371 Score = 112 bits (279), Expect = 4e-25, Method: Composition-based stats. Identities = 63/359 (17%), Positives = 120/359 (33%), Gaps = 72/359 (20%) Query: 34 PEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGV 93 + V +R+ I +D + G + G VV VGSDV+ VGD V Sbjct: 36 RDQVYVRVEAVAINPSDTKM-RGQFATPWAF--LGTDYAGTVVAVGSDVTHIQVGDRV-- 90 Query: 94 GCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGM 153 + CP+ P QG F++ TV + KIP+G+ Sbjct: 91 -------------YGAQNEMCPR------------TPDQGAFSQYTVTRGRVWAKIPKGL 125 Query: 154 AVEQAAPLLCAGVTVYSPLSHFGLKQPG------------LRGGILGLG-GVGHMGVKIA 200 + EQAA L T + GL P + + G + +++ Sbjct: 126 SFEQAAALPAGISTAGLAMKLLGLPLPSPSADQPPTHSKPVYVLVYGGSTATATVTMQML 185 Query: 201 KAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL----ADSLDYVIDTVPVHH 256 + G+ I++ + + + GA++ + ++L Y +D + Sbjct: 186 RLSGY--IPIATCSPHNFDLAKSRGAEEVFDYRAPNLAQTIRTYTKNNLRYALDCITNVE 243 Query: 257 ALEPYLSLLKL-DGKLILMGVINNPL---QFLTPLLMLGRKVI-TGSFI-------GSMK 304 + + + G + + + +T LG + GS GS + Sbjct: 244 STTFCFAAIGRAGGHYVSLNPFPEHAATRKMVTTDWTLGPTIFGEGSTWPAPYGRPGSEE 303 Query: 305 ETEE-------MLEFCKEKGLSSI---IEVVKMDYVNTAFERLEKNDVRY-RFVVDVEG 352 E + + ++ L + D++ E + K ++ + VV +EG Sbjct: 304 ERQFGEDLWRIAGQLVEDGRLVHHPLRVVQGGFDHIKQGMELVRKGELSGEKLVVRLEG 362 >2VWH-A nrPDB Length = 357 Score = 98.5 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 53/331 (16%), Positives = 106/331 (32%), Gaps = 30/331 (9%) Query: 28 TLRETGPEDVNIRIICCGICHTDLHQT---KNDLGMSNYPMVPGHEVVGEVVEVGSDVSK 84 E + +R + G+ TD +V GHE VG VV+ + ++ Sbjct: 19 PRPEPESGEALVRTLRVGVDGTDHEVIAGGHGGFPEGEDHLVLGHEAVGVVVD--PNDTE 76 Query: 85 FTVGDIVG-VGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQ 143 GDIV G ERD P ++ + G ++ + Sbjct: 77 LEEGDIVVPTVRRPPASGTNEYFERDQPDMAPDGMYFERGI----VGAHGYMSEFFTSPE 132 Query: 144 KFVVKIPEGMAVEQAAPLLCAGVTV----YSPLSHFGLKQPGLRGGILGLGGVGHMGVKI 199 K++V+IP E + +T ++ S +LG G +G + + + Sbjct: 133 KYLVRIPRS-QAELGFLIEPISITEKALEHAYASRSAFDWDPSSAFVLGNGSLGLLTLAM 191 Query: 200 AKA--MGHHVTVI---SSSNKKREEALQDLGADDYVIGSDQ-AKMSELADSLDYVIDTVP 253 K G+ + +++L A + ++ + +D++ + Sbjct: 192 LKVDDKGYENLYCLGRRDRPDPTIDIIEELDATYVDSRQTPVEDVPDVYEQMDFIYEATG 251 Query: 254 VHHALEPYLSLLKLDGKLILMGVINN-PLQFLTPLLMLGRKVITGSFIGSMKETEEMLEF 312 + L +G L+GV ++ + + + +GS+ E E Sbjct: 252 FPKHAIQSVQALAPNGVGALLGVPSDWAFEVDAGAFHREMVLHNKALVGSVNSHVEHFEA 311 Query: 313 CK---EKGLSSIIE-----VVKMDYVNTAFE 335 K +E V + AF+ Sbjct: 312 ATVTFTKLPKWFLEDLVTGVHPLSEFEAAFD 342 >2CDC-A nrPDB Length = 366 Score = 95.8 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 62/346 (17%), Positives = 115/346 (33%), Gaps = 43/346 (12%) Query: 35 EDVNIRIICCGICHTDLHQTKNDLGMSNYP-----MVPGHEVVGEVVEVGSDVSKFTVGD 89 + IR I GIC D L +S P +V GHE +G V E F+ GD Sbjct: 27 GKIKIRTIYNGICGADREIVNGKLTLSTLPKGKDFLVLGHEAIGVVEE---SYHGFSQGD 83 Query: 90 IVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKI 149 +V + CG C C +C + ++ G + K++VKI Sbjct: 84 LV-MPVNRRGCGICRNCLVGRPDFCETGEFGEAGIH----KMDGFMREWWYDDPKYLVKI 138 Query: 150 PEGMAV--EQAAPLLCAGVTVYSPLSHFGLKQPGLR----------GGILGLGGVGHMGV 197 P+ + A PL ++ L + P ++G G +G + Sbjct: 139 PKSIEDIGILAQPLADIEKSIEEIL-EVQKRVPVWTCDDGTLNCRKVLVVGTGPIGVLFT 197 Query: 198 KIAKAMGHHVTVISSSNKKREEA--LQDLGADDYVIGSDQAKMSELADSLDYVIDTVPVH 255 + + G V + + E +++ + Y + K+ + D +ID Sbjct: 198 LLFRTYGLEVWMANRREPTEVEQTVIEETKTNYYNSSNGYDKLKDSVGKFDVIIDATGAD 257 Query: 256 -HALEPYLSLLKLDGKLILMGVI-NNPLQFLTPLL---MLGRKVITGSFIGSMKETEEML 310 + L + LL +G L L G + + L + K I G G ++ + Sbjct: 258 VNILGNVIPLLGRNGVLGLFGFSTSGSVPLDYKTLQEIVHTNKTIIGLVNGQKPHFQQAV 317 Query: 311 ----------EFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRF 346 + ++ + + + E +++ R Sbjct: 318 VHLASWKTLYPKAAKMLITKTVSINDEKELLKVLREKEHGEIKIRI 363 >5LB9-A nrPDB Length = 385 Score = 91.2 bits (225), Expect = 7e-19, Method: Composition-based stats. Identities = 54/339 (15%), Positives = 110/339 (32%), Gaps = 59/339 (17%) Query: 16 RDPSGILSPYTYTLRE--TGPEDVNIRIICCGICHTDLHQTKN----------DLGMSNY 63 +P +L ++ + + P +V ++ + + +D++Q + G + Sbjct: 34 GEPKDVLFTQSFEIDDDNLAPNEVIVKTLGSPVNPSDINQIQGVYPSKPAKTTGFGTTEP 93 Query: 64 PMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYND 123 G+E + EV++VGS+VS GD V P + + + + +D Sbjct: 94 AAPCGNEGLFEVIKVGSNVSSLEAGDWVI------------PSHVNFGTWRTHALGNDDD 141 Query: 124 VYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLR 183 P Q P G+ + Q A + + Y L+H+ PG Sbjct: 142 FIKLPNPAQSK-----------ANGKPNGLTINQGATISVNPLVAYLMLTHYVKLTPGKD 190 Query: 184 GGI--LGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEA---LQDLGADDYV----IGSD 234 I G VG +I K + + + +E L++LGA + S Sbjct: 191 WFIQNGGTSAVGKYASQIGKLLNFNSISVIRDRPNLDEVVASLKELGATQVITEDQNNSR 250 Query: 235 Q------AKMSELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLL 288 + + + ++ V + L L G+ P+ T L Sbjct: 251 EFGPTIKEWIKQSGGEAKLALNCVGGKSSTGIARKLNNNGLMLTYGGMSFQPVTIPTSLY 310 Query: 289 MLGRKVITGSFIG---------SMKETEEMLEFCKEKGL 318 + G ++ +++ + +E L Sbjct: 311 IFKNFTSAGFWVTELLKNNKELKTSTLNQIIAWYEEGKL 349 >1V3V-A nrPDB Length = 333 Score = 86.6 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 48/244 (19%), Positives = 87/244 (35%), Gaps = 29/244 (11%) Query: 131 TQGGFAKATVVH----QKFVVKIPEGMAVEQA-APLLCAGVTVYSPLSHFGLKQPGLRGG 185 Q G+ + +K + + P+ + + A + G+T Y L + G Sbjct: 91 AQSGWTTHFISDGKGLEKLLTEWPDKLPLSLALGTIGMPGLTAYFGLLEVCGVKGGETVL 150 Query: 186 ILGL-GGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADD-----YVIGSDQAKMS 239 + G VG + +IAK G V + S++K L+ +G D V ++A Sbjct: 151 VSAAAGAVGSVVGQIAKLKGCKVVGAAGSDEK-IAYLKQIGFDAAFNYKTVNSLEEALKK 209 Query: 240 ELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVIN--------NPLQFLTPLLMLG 291 D D D V L LS +K GK+ + G I+ P ++ Sbjct: 210 ASPDGYDCYFDNVGGEF-LNTVLSQMKDFGKIAICGAISVYNRMDQLPPGPSPES-IIYK 267 Query: 292 RKVITGSFIGSM------KETEEMLEFCKEKGLSSIIEVVK-MDYVNTAFERLEKNDVRY 344 + I G + K +++++ E + V K + + AF + Sbjct: 268 QLRIEGFIVYRWQGDVREKALRDLMKWVLEGKIQYHEHVTKGFENMPAAFIEMLNGANLG 327 Query: 345 RFVV 348 + VV Sbjct: 328 KAVV 331 >3WID-A nrPDB Length = 369 Score = 85.4 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 59/305 (19%), Positives = 114/305 (37%), Gaps = 34/305 (11%) Query: 18 PSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYP-----MVPGHEVV 72 P G + + E + ++ + GIC TD + L + P +V GHE + Sbjct: 12 PKGGVKYTKIDMPEPEKYEAKLKPVYIGICGTDRGEVAGALSFTYNPEGENFLVLGHEAL 71 Query: 73 GEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQ 132 +V++V SD + GD V LV G C C + C ++ I G Sbjct: 72 LQVLDV-SDNNYIKRGDFVV--PLVRRPGKCVNCRIGRQDNCSIGDPDKHEAGITGLH-- 126 Query: 133 GGFAKATVVHQ-KFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQP----------- 180 GF + + + +VK+ + + + A L V F + Sbjct: 127 -GFMRDVIYDDIQNLVKVNDP-DLGKIAVLTEPLKNVMKAFEVFDVVSKRSIFQNDDSTF 184 Query: 181 -GLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMS 239 G + ++G G + + K G VT + + + + E ++ + DD+ +G + Sbjct: 185 IGKKMVVIGSGSEAFLYSFVGKDRGFDVT-MVNRHDETENKMKMM--DDFGVGFSN-YLK 240 Query: 240 ELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTP-----LLMLGRKV 294 ++ D +D ++DT + ++ + +G +IL G + ++ Sbjct: 241 DMPDKIDLLVDTSGDPSTIFKFVKKVNNNGVVILFGFNGKAPGYPVNGEDIDYIVERNIT 300 Query: 295 ITGSF 299 I GS Sbjct: 301 IAGSV 305 >1O89-A nrPDB Length = 345 Score = 85.1 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 64/361 (17%), Positives = 121/361 (33%), Gaps = 50/361 (13%) Query: 5 EAERKTTGWAARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKN-DLGMSNY 63 +A + +D + S T DV + + + + D + N+ Sbjct: 19 KAGLQALLLEQQDGKTLASVQTLDESRLPEGDVTVDVHWSSLNYKDALAITGKGKIIRNF 78 Query: 64 PMVPGHEVVGEVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYND 123 PM+PG + G V S+ +F G V + Sbjct: 79 PMIPGIDFAGTVRT--SEDPRFHAGQEVLLTGW--------------------------- 109 Query: 124 VYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYS---PLSHFGLKQP 180 G+ GG A+ V ++V +P+G+ +A + AG T L G++ Sbjct: 110 --GVGENHWGGLAEQARVKGDWLVAMPQGLDARKAMIIGTAGFTAMLCVMALEDAGVRPQ 167 Query: 181 GLRGGILGL-GGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMS 239 + G GGVG V + +G + V S + E L+ LGA + + A+ Sbjct: 168 DGEIVVTGASGGVGSTAVALLHKLG-YQVVAVSGRESTHEYLKSLGASRVLPRDEFAESR 226 Query: 240 ELADSL-DYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGS 298 L + IDTV L L+ + G + G+ T ++ + + Sbjct: 227 PLEKQVWAGAIDTVG-DKVLAKVLAQMNYGGCVAACGLAGG-FTLPTTVMPFILRNVRLQ 284 Query: 299 FIGSMKETEE---------MLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVD 349 + S+ E + + + + + + + E + N ++ R +V Sbjct: 285 GVDSVMTPPERRAQAWQRLVADLPESFYTQAA-KEISLSEAPNFAEAIINNQIQGRTLVK 343 Query: 350 V 350 V Sbjct: 344 V 344 >5GXF-A nrPDB Length = 330 Score = 80.4 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 60/330 (18%), Positives = 101/330 (30%), Gaps = 46/330 (13%) Query: 35 EDVNIRIICCGICHTD-LHQTKNDLGMSNYPMVPGHEVVGEVVEVGSDVSKFTVGDIVGV 93 +V + + + + D L + YP VPG + G V S ++ GD V + Sbjct: 31 GEVTVAVEYSTVNYKDGLCIGPGGGLVRKYPHVPGIDFAGTVEN--SSDERYKPGDKVVL 88 Query: 94 GCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGM 153 G+ GG+++ V ++V +PEG+ Sbjct: 89 TGWR-----------------------------VGEAHWGGYSQKANVRADWLVPLPEGL 119 Query: 154 AVEQAAPLLCAGVTVYS---PLSHFGLKQPGLRGGILG-LGGVGHMGVKIAKAMGHHVTV 209 QA + AG T L GL + G GGVG + I +G+ V Sbjct: 120 DTRQAMAVGTAGFTAMLAVMALEDHGLTPGHGPVLVTGAAGGVGSVATAILAHLGYEV-A 178 Query: 210 ISSSNKKREEALQDLGADDYVIGSD--QAKMSELADSL-DYVIDTVPVHHALEPYLSLLK 266 + + + L LGA V + + L + +D V + Sbjct: 179 AVTGRPETADYLTSLGATQIVARDEINETVKRPLESEIWAGCVDAVGGAMLARVLGQMKY 238 Query: 267 LDGKLILMGVINNPLQFLTPLLMLGRKVITG--SFIGSMKETEEMLEFCKE----KGLSS 320 + L +L + G S + E L + Sbjct: 239 GASVAAVGLAGGAGLPATVIPFLLRGVNLLGIDSVMQPYANRLRAWERIARDLPMDKLEA 298 Query: 321 IIEVVKMDYVNTAFERLEKNDVRYRFVVDV 350 +I + + + K V+ R VVDV Sbjct: 299 MIRPATLSDLPGLGADILKGQVQGRVVVDV 328 >2J3K-A nrPDB Length = 345 Score = 75.8 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 37/210 (17%), Positives = 76/210 (36%), Gaps = 19/210 (9%) Query: 160 PLLCAGVTVYSPLSHFGLKQPGLRGGILGL-GGVGHMGVKIAKAMGHHVTVISSSNKKRE 218 L G+T Y+ + G + G VG + ++AK MG +V + S +K + Sbjct: 135 LLGMPGMTAYAGFYEVCSPKEGETVYVSAASGAVGQLVGQLAKMMGCYVVGSAGSKEKVD 194 Query: 219 EALQDLGADDYVIGSDQAKMSE-----LADSLDYVIDTVPVHHALEPYLSLLKLDGKLIL 273 G DD +++ ++ + +D + V L+ L + + G++ + Sbjct: 195 LLKTKFGFDDAFNYKEESDLTAALKRCFPNGIDIYFENVGG-KMLDAVLVNMNMHGRIAV 253 Query: 274 MG------VINNPLQFLTPLLMLGRKVITGSFIGSMKE-----TEEMLEFCKEKGLSSII 322 G + N ++ R I G + + E +L +E ++ + Sbjct: 254 CGMISQYNLENQEGVHNLSNIIYKRNRIQGFVVSDFYDKYSKFLEFVLPHIREGKITYVE 313 Query: 323 EVVK-MDYVNTAFERLEKNDVRYRFVVDVE 351 +V ++ A L + VV V Sbjct: 314 DVADGLEKAPEALVGLFHGKNVGKQVVVVA 343 >2Y05-A nrPDB Length = 328 Score = 70.8 bits (172), Expect = 9e-13, Method: Composition-based stats. Identities = 40/227 (17%), Positives = 80/227 (35%), Gaps = 23/227 (10%) Query: 143 QKFVVKIPEGMAVEQA-APLLCAGVTVYSPLSHFGLKQPGLRGGI-LGLGGVGHMGVKIA 200 +K + + P+ + + A + G+T Y L + G + G VG + +IA Sbjct: 102 EKLLTEWPDTIPLSLALGTVGMPGLTAYFGLLEICGVKGGETVMVNAAAGAVGSVVGQIA 161 Query: 201 KAMGHHVTVISSSNKKREEALQDLGADDYVIGS-----DQAKMSELADSLDYVIDTVPVH 255 K G V S++K LQ LG D ++ D D D V Sbjct: 162 KLKGCKVVGAVGSDEK-VAYLQKLGFDVVFNYKTVESLEETLKKASPDGYDCYFDNVGGE 220 Query: 256 HALEPYLSLLKLDGKLILMGVINN-------PLQFLTPLLMLGRKVITGSFI------GS 302 + + +K G++ + G I+ P +++ + + Sbjct: 221 FS-NTVIGQMKKFGRIAICGAISTYNRTGPLPPGPPPEIVIYQELRMEAFVVYRWQGDAR 279 Query: 303 MKETEEMLEFCKEKGLS-SIIEVVKMDYVNTAFERLEKNDVRYRFVV 348 K +++L++ E + + + + AF + K D + +V Sbjct: 280 QKALKDLLKWVLEGKIQYKEYIIEGFENMPAAFMGMLKGDNLGKTIV 326 >1SEZ-A nrPDB Length = 504 Score = 45.0 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 21/118 (17%), Positives = 44/118 (37%), Gaps = 7/118 (5%) Query: 182 LRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL 241 R ++G G G K G +VTV + K L+ + D + M+E Sbjct: 14 KRVAVIGAGVSGLAAAYKLKIHGLNVTVF-EAEGKAGGKLRSVSQDGLIWDEGANTMTES 72 Query: 242 ADSLDYVIDTVPVHH----ALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVI 295 + ++ID++ + L + +G +L + +NP+ + + + Sbjct: 73 EGDVTFLIDSLGLREKQQFPLSQNKRYIARNGTPVL--LPSNPIDLIKSNFLSTGSKL 128 >2VHY-A nrPDB Length = 377 Score = 44.6 bits (104), Expect = 6e-05, Method: Composition-based stats. Identities = 31/143 (21%), Positives = 52/143 (36%), Gaps = 15/143 (10%) Query: 149 IPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQ------PGLR---GGILGLGGVGHMGVKI 199 +P + + A L A V Y + G + PG+ ++G G G+ +I Sbjct: 127 LPLLAPMSEVAGRLAAQVGAYHLMRTQGGRGVLMGGVPGVEPADVVVIGAGTAGYNAARI 186 Query: 200 AKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDYVIDTVPVHHALE 259 A MG VTV+ + K + + + S ++ D VI V V A Sbjct: 187 ANGMGATVTVLDINIDKLRQLDAEFCGRIHTRYSSAYELEGAVKRADLVIGAVLVPGAKA 246 Query: 260 PYLSL------LKLDGKLILMGV 276 P L +K L+ + + Sbjct: 247 PKLVSNSLVAHMKPGAVLVDIAI 269 >6BII-A nrPDB Length = 333 Score = 43.8 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 28/112 (25%), Positives = 47/112 (41%), Gaps = 14/112 (12%) Query: 168 VYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGAD 227 + P G G GI+G G +G K AK G ++ ++ ++ EA ++LGA Sbjct: 137 AWHPKMFLGYDVYGKTIGIVGFGRIGQAIAKRAKGFGMR--ILYTARSRKPEAEKELGA- 193 Query: 228 DYVIGSDQAKMSELADSLDYVIDTVPVHHAL-----EPYLSLLKLDGKLILM 274 + + EL D+V+ VP+ E L L+K L+ + Sbjct: 194 ------EFKPLEELLRESDFVVLAVPLTKETYHMINEERLRLMKPTAVLVNV 239 >2EEZ-A nrPDB Length = 369 Score = 42.7 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 26/100 (26%), Positives = 42/100 (42%), Gaps = 6/100 (6%) Query: 183 RGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELA 242 ILG G VG KIA MG VT++ ++K+ + G + + +A + + Sbjct: 168 SVVILGGGTVGTNAAKIALGMGAQVTILDVNHKRLQYLDDVFGGRVITLTATEANIKKSV 227 Query: 243 DSLDYVIDTVPVHHA------LEPYLSLLKLDGKLILMGV 276 D +I V V A LSL+K ++ + V Sbjct: 228 QHADLLIGAVLVPGAKAPKLVTRDMLSLMKEGAVIVDVAV 267 >5AOV-A nrPDB Length = 336 Score = 40.8 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 26/112 (23%), Positives = 46/112 (41%), Gaps = 14/112 (12%) Query: 168 VYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGAD 227 + P G + G GI+G G +G + AK ++ S ++ +A ++LGA Sbjct: 137 AWHPKWFLGYELYGKTIGIVGFGRIGQAIARRAKGFNMR--ILYYSRTRKSQAEKELGA- 193 Query: 228 DYVIGSDQAKMSELADSLDYVIDTVP-VHHAL----EPYLSLLKLDGKLILM 274 + + E+ D+VI VP + E L L+K L+ + Sbjct: 194 ------EYRPLEEVLKESDFVILAVPLTKETMYMINEERLKLMKPTAILVNI 239 >1DXY-A nrPDB Length = 333 Score = 40.8 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 27/156 (17%), Positives = 52/156 (33%), Gaps = 18/156 (11%) Query: 170 SPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDY 229 + G + G++G G +G + +K+ K G V K + Sbjct: 134 KAGTFIGKELGQQTVGVMGTGHIGQVAIKLFKGFGAKVIAYDPYPMKGDH---------- 183 Query: 230 VIGSDQAKMSELADSLDYV-IDTVPVHHAL----EPYLSLLKLDGKLILMGVINNPLQFL 284 D + +L D + + + E +L+K G +++ N + Sbjct: 184 -PDFDYVSLEDLFKQSDVIDLHVPGIEQNTHIINEAAFNLMKP-GAIVINTARPNLIDTQ 241 Query: 285 TPLLMLGRKVITGSFIGSMK-ETEEMLEFCKEKGLS 319 L L + G I + + ETE++L K Sbjct: 242 AMLSNLKSGKLAGVGIDTYEYETEDLLNLAKHGSFK 277 >1ZCJ-A nrPDB Length = 463 Score = 40.4 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 16/61 (26%), Positives = 27/61 (44%), Gaps = 3/61 (4%) Query: 165 GVTVYSPLSHFGLKQPGLRGGILGLGGVG-HMGVKIAKAMGHHVTVISSSNKKREEALQD 223 T QP G+LGLG +G + + A+ +G V V S+ K+ +A + Sbjct: 21 WSTPSGASWKTASAQPVSSVGVLGLGTMGRGIAISFAR-VGISV-VAVESDPKQLDAAKK 78 Query: 224 L 224 + Sbjct: 79 I 79 >2RIR-A nrPDB Length = 300 Score = 40.0 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 21/101 (20%), Positives = 42/101 (41%), Gaps = 5/101 (4%) Query: 167 TVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGA 226 T+ + H G + +LGLG G + A+G +V V + S+ + ++G Sbjct: 143 TIMLAIQHTDYTIHGSQVAVLGLGRTGMTIARTFAALGANVKVGARSSAH-LARITEMG- 200 Query: 227 DDYVIGSDQAKMSELADSLDYVIDTVPVHHALEPYLSLLKL 267 ++ ++ E +D I+T+P + LS + Sbjct: 201 ---LVPFHTDELKEHVKDIDICINTIPSMILNQTVLSSMTP 238 >1XLT-A nrPDB Length = 384 Score = 39.6 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 15/77 (19%), Positives = 29/77 (37%), Gaps = 1/77 (1%) Query: 168 VYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGAD 227 + + P R + G+G G + AK +G V + + +E ++ LG Sbjct: 159 AFPMMMTAAGTVPPARVLVFGVGVAGLQAIATAKRLGA-VVMATDVRAATKEQVESLGGK 217 Query: 228 DYVIGSDQAKMSELADS 244 + + K +E A Sbjct: 218 FITVDDEAMKTAETAGG 234 >3ZWA-A nrPDB Length = 742 Score = 39.6 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 16/61 (26%), Positives = 27/61 (44%), Gaps = 3/61 (4%) Query: 165 GVTVYSPLSHFGLKQPGLRGGILGLGGVG-HMGVKIAKAMGHHVTVISSSNKKREEALQD 223 T QP G+LGLG +G + + A+ +G V V S+ K+ +A + Sbjct: 300 WSTPSGASWKTASAQPVSSVGVLGLGTMGRGIAISFAR-VGISV-VAVESDPKQLDAAKK 357 Query: 224 L 224 + Sbjct: 358 I 358 >4DIO-A nrPDB Length = 405 Score = 39.2 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 14/77 (18%), Positives = 28/77 (36%), Gaps = 1/77 (1%) Query: 168 VYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGAD 227 + P + ++G G G + A+ +G V + +E + LGA Sbjct: 177 ALPMMMTAAGTVPAAKIFVMGAGVAGLQAIATARRLGA-VVSATDVRPAAKEQVASLGAK 235 Query: 228 DYVIGSDQAKMSELADS 244 + ++ K +E A Sbjct: 236 FIAVEDEEFKAAETAGG 252 >3MGG-A nrPDB Length = 276 Score = 36.9 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 24/136 (17%), Positives = 47/136 (34%), Gaps = 26/136 (19%) Query: 157 QAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKK 216 +A L T+ L H + PG + G G +G V +AK + + Sbjct: 14 EALRLSEQAETLEKLLHHDTVYPPGAKVLEAGCG-IGAQTVILAKNNPDAEITSIDISPE 72 Query: 217 REEALQD------------LGADDYVIGSDQAKMSELADSLDYVIDTVPVHH------AL 258 E ++ L A+ + + + + S D++ + H AL Sbjct: 73 SLEKARENTEKNGIKNVKFLQANIFSLPFEDS-------SFDHIFVCFVLEHLQSPEEAL 125 Query: 259 EPYLSLLKLDGKLILM 274 + +LK G + ++ Sbjct: 126 KSLKKVLKPGGTITVI 141 >2WWR-A nrPDB Length = 330 Score = 36.9 bits (84), Expect = 0.013, Method: Composition-based stats. Identities = 41/177 (23%), Positives = 59/177 (33%), Gaps = 34/177 (19%) Query: 164 AGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQ- 222 G T + PL G GI+GLG +G + K G + + + EEA + Sbjct: 138 GGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRFLYTGRQPRPEEAAEF 197 Query: 223 --------DLGA-DDYV--------------IGSDQAKMSELADSLDYVIDTVPVHHALE 259 +L A D++ KM E A ++ V L Sbjct: 198 QAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVFINISRGDVVNQDDLY 257 Query: 260 PYLSLLKLDGKLILMGV---INNPLQFLTPLLMLGRKVIT---GSFIGSMKETEEML 310 L+ GK+ G+ PL PLL L VI GS + T +L Sbjct: 258 QALAS----GKIAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIGSATHRTRNTMSLL 310 >5ILO-A nrPDB Length = 271 Score = 36.5 bits (83), Expect = 0.016, Method: Composition-based stats. Identities = 16/95 (16%), Positives = 29/95 (30%), Gaps = 15/95 (15%) Query: 175 FGLKQPGLRGGILG-LGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGAD------ 227 G G + G GG+G K A G I EE ++ A Sbjct: 9 VGTSFRGKNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEFVKLRAAHPTQSVM 68 Query: 228 ----DYVIGS----DQAKMSELADSLDYVIDTVPV 254 D ++++ ++D V++ + Sbjct: 69 IIKMDVANKKGVEATYEEIAKTFGNIDIVVNVAGI 103 >2YVG-A nrPDB Length = 408 Score = 36.5 bits (83), Expect = 0.016, Method: Composition-based stats. Identities = 20/131 (15%), Positives = 43/131 (32%), Gaps = 10/131 (7%) Query: 150 PEGMAVEQAAPLLCAGV-TVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVT 208 P + Q A + + T+ +P R I+G G +G A+ G HV+ Sbjct: 113 PRALPTLQGATMPVHTLRTLEDARRIQAGLRPQSRLLIVGGGVIGLELAATARTAGVHVS 172 Query: 209 VISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDYVID--TVPVHHALEPYLSLLK 266 ++ + + A AD A +D + + + Sbjct: 173 LVETQPRLMSRAAPATLADFVARYH-------AAQGVDLRFERSVTGSVDGVVLLDDGTR 225 Query: 267 LDGKLILMGVI 277 + ++++G+ Sbjct: 226 IAADMVVVGIG 236 >2EGU-A nrPDB Length = 308 Score = 36.5 bits (83), Expect = 0.018, Method: Composition-based stats. Identities = 16/83 (19%), Positives = 30/83 (36%), Gaps = 2/83 (2%) Query: 170 SPLSHFGLKQPGLRGG--ILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGAD 227 G +PG G G+G V AK + + + + +R L+ GA+ Sbjct: 54 EAAEKAGKLKPGDTIVEPTSGNTGIGLAMVAAAKGYKAVLVMPDTMSLERRNLLRAYGAE 113 Query: 228 DYVIGSDQAKMSELADSLDYVID 250 + Q +A + + V + Sbjct: 114 LVLTPGAQGMRGAIAKAEELVRE 136 >1JG3-A nrPDB Length = 235 Score = 36.5 bits (83), Expect = 0.020, Method: Composition-based stats. Identities = 37/175 (21%), Positives = 62/175 (35%), Gaps = 22/175 (12%) Query: 135 FAKATVVHQKF--VVKIPEGMAVEQAAPLLCAGVTVYSP-----LSHFGLKQPGLRGGIL 187 + + V K+ I E + + AG TV +P + +PG+ + Sbjct: 46 YPRYLSVEDKYKKYAHIDEPLP-------IPAGQTVSAPHMVAIMLEIANLKPGMNILEV 98 Query: 188 GLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQD----LGA-DDYVIGSDQAKMSELA 242 G G G I++ + V I + E + G + +VI D +K Sbjct: 99 GTGS-GWNAALISEIVKTDVYTI-ERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPK 156 Query: 243 DSLDYVIDTVPVHHALEPYLSLLKLDGKLIL-MGVINNPLQFLTPLLMLGRKVIT 296 D +I T EP + LK+ GKLI+ +G + + L I Sbjct: 157 APYDVIIVTAGAPKIPEPLIEQLKIGGKLIIPVGSYHLWQELLEVRKTKDGIKIK 211 >3GG9-A nrPDB Length = 352 Score = 35.8 bits (81), Expect = 0.027, Method: Composition-based stats. Identities = 19/78 (24%), Positives = 28/78 (35%), Gaps = 5/78 (6%) Query: 166 VTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLG 225 T P G G GI G G +G + +A G +V V N K Sbjct: 145 STTMPPNFGIGRVLKGQTLGIFGYGKIGQLVAGYGRAFGMNVLVWGRENSKERAR----- 199 Query: 226 ADDYVIGSDQAKMSELAD 243 AD + + + + E +D Sbjct: 200 ADGFAVAESKDALFEQSD 217 >1LSS-A nrPDB Length = 140 Score = 35.8 bits (81), Expect = 0.029, Method: Composition-based stats. Identities = 17/83 (20%), Positives = 33/83 (39%) Query: 151 EGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVI 210 + + E A ++ T L G++ + + G V M +AK+ G + T+ Sbjct: 41 KKASAEIDALVINGDCTKIKTLEDAGIEDADMYIAVTGKEEVNLMSSLLAKSYGINKTIA 100 Query: 211 SSSNKKREEALQDLGADDYVIGS 233 S + ++ + LG D V Sbjct: 101 RISEIEYKDVFERLGVDVVVSPE 123 >2C2Y-A nrPDB Length = 281 Score = 35.8 bits (81), Expect = 0.030, Method: Composition-based stats. Identities = 20/126 (15%), Positives = 36/126 (28%), Gaps = 20/126 (15%) Query: 159 APLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKRE 218 APL C + L + + G ++G G V Sbjct: 136 APLPCTPRGIVHLLRRYDISIAGAHVVVIGRG------------------VTVGRPLGLL 177 Query: 219 EALQDLGADDYVIGSDQAKMSELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVIN 278 + A + + + L D V+ V V H L +++ +I +GV Sbjct: 178 LTRRSENATVTLCHTGTRDLPALTRQADIVVAAVGVAHLLTA--DMVRPGAAVIDVGVSR 235 Query: 279 NPLQFL 284 + Sbjct: 236 TDDGLV 241 >1CYD-A nrPDB Length = 244 Score = 35.8 bits (81), Expect = 0.030, Method: Composition-based stats. Identities = 14/48 (29%), Positives = 21/48 (43%), Gaps = 1/48 (2%) Query: 177 LKQPGLRGGILGLG-GVGHMGVKIAKAMGHHVTVISSSNKKREEALQD 223 L GLR + G G G+G VK A G V ++ +N ++ Sbjct: 3 LNFSGLRALVTGAGKGIGRDTVKALHASGAKVVAVTRTNSDLVSLAKE 50 >6C55-A nrPDB Length = 340 Score = 35.4 bits (80), Expect = 0.035, Method: Composition-based stats. Identities = 30/162 (18%), Positives = 57/162 (35%), Gaps = 26/162 (16%) Query: 165 GVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDL 224 TVY G + ++G G GH + K G+ V + + + ++ Sbjct: 1 MTTVYYDQDVKTDALQGKKIAVVGYGSQGHAHAQNLKDNGYDVVIGI-RPGRSFDKAKED 59 Query: 225 GADDYVIGSDQAKMSELADSLDYVIDTVP-----------VHHALEPYLSLLKLDGKLIL 273 G D + ++E D ++ +P + LE + +L G I Sbjct: 60 GFDVF-------PVAEAVKQADVIMVLLPDEIQGDVYKNEIEPNLEKHNALAFAHGFNIH 112 Query: 274 MGVINNPLQFLTPLL-------MLGRKVITGSFIGSMKETEE 308 GVI P L+ ++ R + GS + S+ ++ Sbjct: 113 FGVIQPPADVDVFLVAPKGPGHLVRRTFVEGSAVPSLFGIQQ 154 >3D3W-A nrPDB Length = 244 Score = 35.4 bits (80), Expect = 0.039, Method: Composition-based stats. Identities = 11/45 (24%), Positives = 20/45 (44%), Gaps = 1/45 (2%) Query: 180 PGLRGGILGLG-GVGHMGVKIAKAMGHHVTVISSSNKKREEALQD 223 G R + G G G+G V+ A G V +S + + +++ Sbjct: 6 AGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRE 50 >3EMK-A nrPDB Length = 246 Score = 35.4 bits (80), Expect = 0.042, Method: Composition-based stats. Identities = 17/85 (20%), Positives = 34/85 (40%), Gaps = 11/85 (12%) Query: 181 GLRGGILGL-GGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYV---IGSDQA 236 G + + G GG+G + A G V + + +K +E +LG +V SD+ Sbjct: 7 GRKALVTGATGGLGEAIARALHAQGAIVGLHGTREEKLKELAAELGERIFVFPANLSDRE 66 Query: 237 KMSELA-------DSLDYVIDTVPV 254 + L +D +++ + Sbjct: 67 AVKALGQKAEEEMGGVDILVNNAGI 91 >2BRY-A nrPDB Length = 497 Score = 35.4 bits (80), Expect = 0.044, Method: Composition-based stats. Identities = 16/109 (14%), Positives = 35/109 (32%), Gaps = 26/109 (23%) Query: 112 QYCPKKIWSYNDV-YINGQPTQGGFAKATVVHQ--------KFVVKIPEGMAVEQAAPLL 162 Q C + S+ + G + GG ++ + K+ + + Sbjct: 29 QLCQDVLSSFQGLCRALGVESGGGLSQYHKIKAQLNYWSAKSLWAKLDKRAS-------- 80 Query: 163 CAGVTVYSPLSHFGLKQPGLRGGILGLGGVGH-MGVKIAKAMGHHVTVI 210 P+ G + ++G G G V++A +G V ++ Sbjct: 81 -------QPVYQQGQACTNTKCLVVGAGPCGLRAAVELA-LLGARVVLV 121 >4TXK-A nrPDB Length = 615 Score = 35.0 bits (79), Expect = 0.051, Method: Composition-based stats. Identities = 16/109 (14%), Positives = 35/109 (32%), Gaps = 26/109 (23%) Query: 112 QYCPKKIWSYNDV-YINGQPTQGGFAKATVVHQ--------KFVVKIPEGMAVEQAAPLL 162 Q C + S+ + G + GG ++ + K+ + + Sbjct: 21 QLCQDVLSSFQGLCRALGVESGGGLSQYHKIKAQLNYWSAKSLWAKLDKRAS-------- 72 Query: 163 CAGVTVYSPLSHFGLKQPGLRGGILGLGGVGH-MGVKIAKAMGHHVTVI 210 P+ G + ++G G G V++A +G V ++ Sbjct: 73 -------QPVYQQGQACTNTKCLVVGAGPCGLRAAVELA-LLGARVVLV 113 >1X14-A nrPDB Length = 401 Score = 35.0 bits (79), Expect = 0.056, Method: Composition-based stats. Identities = 12/53 (22%), Positives = 24/53 (45%), Gaps = 1/53 (1%) Query: 175 FGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGAD 227 K P + ++G G G + A ++G V + + + E +Q +GA+ Sbjct: 166 AAGKVPPAKVMVIGAGVAGLAAIGAANSLGAIVRAFDTRPEVK-EQVQSMGAE 217 >3VPX-A nrPDB Length = 364 Score = 35.0 bits (79), Expect = 0.059, Method: Composition-based stats. Identities = 9/82 (10%), Positives = 27/82 (32%), Gaps = 2/82 (2%) Query: 180 PGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMS 239 G + G+G V + + G + + + + + A+ GA I ++ + Sbjct: 172 AGKTVAVQGVGNVAYALCEYLHEEGAKLIITDINEEAVQRAVDAFGATAVGINEIYSQEA 231 Query: 240 ELADSLDYVIDTVPVHHALEPY 261 ++ + + + Sbjct: 232 DIFAP--CALGAIINDETIPQL 251 >3OAM-A nrPDB Length = 252 Score = 34.6 bits (78), Expect = 0.074, Method: Composition-based stats. Identities = 18/102 (17%), Positives = 40/102 (39%), Gaps = 8/102 (7%) Query: 167 TVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGA 226 TV P + + PG +G + + A G +I++ +++ E+A+Q G Sbjct: 4 TVVIPARYQSTRLPGKPLADIGGKPMIQWVYEQAMQAGADRVIIATDDERVEQAVQAFGG 63 Query: 227 DDYVIGSDQ--------AKMSELADSLDYVIDTVPVHHALEP 260 + + ++++A D+++ V L P Sbjct: 64 VVCMTSPNHQSGTERLAEVVAKMAIPADHIVVNVQGDEPLIP 105 >4FHN-X nrPDB Length = 450 Score = 34.2 bits (77), Expect = 0.083, Method: Composition-based stats. Identities = 12/47 (25%), Positives = 19/47 (40%) Query: 168 VYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSN 214 + L G+ G+R + G G V ++ A G V S S+ Sbjct: 222 TEAMLKRHGMGFEGMRVSVSGSGNVAQYAIEKAMEFGARVITASDSS 268 >5IJZ-A nrPDB Length = 447 Score = 34.2 bits (77), Expect = 0.088, Method: Composition-based stats. Identities = 17/76 (22%), Positives = 28/76 (36%), Gaps = 10/76 (13%) Query: 168 VYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGAD 227 V + G G + + G G V ++ A+ +G V S S+ G Sbjct: 220 VSEMIKAKGESISGQKIIVSGSGNVATYAIEKAQELGATVIGFSDSS----------GWV 269 Query: 228 DYVIGSDQAKMSELAD 243 G D AK+ E+ + Sbjct: 270 HTPNGVDVAKLREIKE 285 >5JJC-A nrPDB Length = 342 Score = 34.2 bits (77), Expect = 0.091, Method: Composition-based stats. Identities = 15/64 (23%), Positives = 33/64 (51%), Gaps = 2/64 (3%) Query: 174 HFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVIS--SSNKKREEALQDLGADDYVI 231 GL +PG G G +AKA+G+ ++ ++++++++AL+ LGA+ + Sbjct: 55 KRGLLRPGGVIVEGTAGNTGIGLTMVAKALGYRTAIVIPETASQEKKDALRLLGAELIEV 114 Query: 232 GSDQ 235 + Sbjct: 115 PAAP 118 >3GRP-A nrPDB Length = 266 Score = 34.2 bits (77), Expect = 0.092, Method: Composition-based stats. Identities = 20/85 (23%), Positives = 37/85 (43%), Gaps = 11/85 (12%) Query: 181 GLRGGILGL-GGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYV---IGSDQA 236 G + + G GG+G + A G V + + K +E DLG D +V SD+ Sbjct: 27 GRKALVTGATGGIGEAIARCFHAQGAIVGLHGTREDKLKEIAADLGKDVFVFSANLSDRK 86 Query: 237 KMSELA-------DSLDYVIDTVPV 254 + +LA + +D +++ + Sbjct: 87 SIKQLAEVAEREMEGIDILVNNAGI 111 >2EKL-A nrPDB Length = 313 Score = 34.2 bits (77), Expect = 0.093, Method: Composition-based stats. Identities = 24/89 (26%), Positives = 35/89 (39%), Gaps = 9/89 (10%) Query: 176 GLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQ 235 GL+ G GI+G G +G IA AMG V RE+A + I + Sbjct: 137 GLELAGKTIGIVGFGRIGTKVGIIANAMGMKVLAY-DILDIREKAEK--------INAKA 187 Query: 236 AKMSELADSLDYVIDTVPVHHALEPYLSL 264 + EL + D + V V +P + Sbjct: 188 VSLEELLKNSDVISLHVTVSKDAKPIIDY 216 >4K28-A nrPDB Length = 269 Score = 34.2 bits (77), Expect = 0.096, Method: Composition-based stats. Identities = 15/61 (24%), Positives = 23/61 (37%), Gaps = 2/61 (3%) Query: 165 GVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKA-MGHHVTVISSSNKKREEALQD 223 G G + G R ++G GGVG + A A G + + R A+ + Sbjct: 109 GAGFLGAAHKHGFEPAGKRALVIGCGGVGS-AIAYALAEAGIASITLCDPSTARMGAVCE 167 Query: 224 L 224 L Sbjct: 168 L 168 >3AOE-A nrPDB Length = 424 Score = 34.2 bits (77), Expect = 0.097, Method: Composition-based stats. Identities = 12/48 (25%), Positives = 18/48 (37%) Query: 165 GVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISS 212 +T + GL+ G R I G G VG+ + G V + Sbjct: 203 FITAAAAAEKIGLQVEGARVAIQGFGNVGNAAARAFHDHGARVVAVQD 250 >3X2F-A nrPDB Length = 411 Score = 33.8 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 26/123 (21%), Positives = 36/123 (29%), Gaps = 9/123 (7%) Query: 162 LCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEAL 221 T + + + L G + G G G A +G V V K EA+ Sbjct: 178 GTGQSTWDAIMRNTNLLVAGKNVVVAGYGWCGRGIALRAAGLGARVIVTEVDPVKAVEAI 237 Query: 222 QDLGADDYVIGSDQAKMSELADSLDYVIDTVPVHHAL-EPYLSLLKLDGKLILMGVINNP 280 D G M E D+VI L + + LK L G N Sbjct: 238 MD-GFTVM-------PMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVE 289 Query: 281 LQF 283 + Sbjct: 290 IPV 292 >1V9L-A nrPDB Length = 421 Score = 33.8 bits (76), Expect = 0.12, Method: Composition-based stats. Identities = 16/59 (27%), Positives = 21/59 (35%), Gaps = 1/59 (1%) Query: 156 EQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSN 214 E A A T +G + G I G+G VG + MG V +S N Sbjct: 186 EYATGFGVAVATREMAKKLWGGIE-GKTVAIQGMGNVGRWTAYWLEKMGAKVIAVSDIN 243 >5NMX-A nrPDB Length = 425 Score = 33.8 bits (76), Expect = 0.12, Method: Composition-based stats. Identities = 27/142 (19%), Positives = 45/142 (31%), Gaps = 33/142 (23%) Query: 183 RGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELA 242 R +LG G G + K G V V E +G +D+ MSE Sbjct: 3 RVAVLGAGPSGLTAARYLKQAGFEVMV--------FERYHHVGGT--WNYTDETWMSE-- 50 Query: 243 DSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIGS 302 D PV+ ++ L + + + F I GS++ S Sbjct: 51 -------DGRPVYSSMYQNL----------FVNLPKELMAFPDFPFHD----IEGSYVPS 89 Query: 303 MKETEEMLEFCKEKGLSSIIEV 324 + + F L +I++ Sbjct: 90 KEVLKYFDNFTDAFDLRKLIKL 111 >4IZO-A nrPDB Length = 419 Score = 33.8 bits (76), Expect = 0.12, Method: Composition-based stats. Identities = 26/101 (25%), Positives = 45/101 (44%), Gaps = 10/101 (9%) Query: 180 PGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGS--DQAK 237 PG G++G G +G M A+AMG+ V V+ A+ AD ++ + D+A Sbjct: 34 PGAWLGMVGGGQLGRMFCFAAQAMGYRVAVLDPDPTSPAGAV----ADKHLRAAYDDEAA 89 Query: 238 MSELADSLDYV---IDTVPVHH-ALEPYLSLLKLDGKLILM 274 ++ELA D V + VP + + G+ + + Sbjct: 90 LAELAQLCDAVSTEFENVPAASLDFLAQSTFVAPAGRCVAI 130 >2YFH-A nrPDB Length = 448 Score = 33.4 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 12/47 (25%), Positives = 19/47 (40%) Query: 168 VYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSN 214 + L G+ G+R + G G V ++ A G V S S+ Sbjct: 218 TEAMLKRHGMGFEGMRVSVSGSGNVAQYAIEKAMEFGARVITASDSS 264 >6C36-A nrPDB Length = 319 Score = 33.4 bits (75), Expect = 0.16, Method: Composition-based stats. Identities = 21/105 (20%), Positives = 40/105 (38%), Gaps = 10/105 (9%) Query: 150 PEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVG--HMGVKIAKAMGHHV 207 P +A + PL AG T Y + L + G+ G+ G+G +AK Sbjct: 178 PAEVAEQYGVPLDRAG-TAY---AELALLRGDPSNGLPGVAGIGEKTAASLLAKHGSLQN 233 Query: 208 TVISSSNKK----REEALQDLGADDYVIGSDQAKMSELADSLDYV 248 + ++ + K + + LGA DY+ ++ + + Sbjct: 234 ILDAAHDPKSGLSKAHRTKLLGAVDYIAAAETVVRVATDAPVTFS 278 >1E3W-A nrPDB Length = 261 Score = 33.1 bits (74), Expect = 0.17, Method: Composition-based stats. Identities = 13/88 (14%), Positives = 28/88 (31%), Gaps = 10/88 (11%) Query: 184 GGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELA- 242 G G+G K G ++ N + E + LG + ++ E+ Sbjct: 14 VITGGASGLGLSTAKRLVGQGATAVLLDVPNSEGETEAKKLGGNCIFAPANVTSEKEVQA 73 Query: 243 ---------DSLDYVIDTVPVHHALEPY 261 +D ++ + A++ Y Sbjct: 74 ALTLAKEKFGRIDVAVNCAGIAVAIKTY 101 >1A5Z-A nrPDB Length = 319 Score = 33.1 bits (74), Expect = 0.17, Method: Composition-based stats. Identities = 34/163 (20%), Positives = 61/163 (37%), Gaps = 37/163 (22%) Query: 183 RGGILGLGGVGHMG--VKIAKAMGHHVTVISSSNKKREEALQDLG-ADDYVIGSDQAKMS 239 + GI+GLG VG + K V+ +KKR E G A D + G+ + + Sbjct: 2 KIGIVGLGRVGSSTAFALLMKGF-AREMVLIDVDKKRAE-----GDALDLIHGTPFTRRA 55 Query: 240 ELA-------DSLDYVIDTVPVH-HALEPYLSLLKLDGKLI--------------LMGVI 277 + D VI V E L LL + +++ ++ V+ Sbjct: 56 NIYAGDYADLKGSDVVIVAAGVPQKPGETRLQLLGRNARVMKEIARNVSKYAPDSIVIVV 115 Query: 278 NNPLQFLTPLLM----LGRKVITGSFIGSMKETEEMLEFCKEK 316 NP+ LT + + + + GS G++ +T + + Sbjct: 116 TNPVDVLTYFFLKESGMDPRKVFGS--GTVLDTARLRTLIAQH 156 >3HM2-A nrPDB Length = 178 Score = 33.1 bits (74), Expect = 0.20, Method: Composition-based stats. Identities = 18/104 (17%), Positives = 36/104 (34%), Gaps = 8/104 (7%) Query: 189 LGGVGHMGVKIAKAMGHHVTVISSSNKKREEA----LQDLGADDYVIGSDQAKMS--ELA 242 GG G + ++ ++ V +++R E +LG D + A + ++ Sbjct: 33 GGGSGSIAIEWLRSTPQTTAVCFEISEERRERILSNAINLGVSDRIAVQQGAPRAFDDVP 92 Query: 243 DSLDYVIDTVP--VHHALEPYLSLLKLDGKLILMGVINNPLQFL 284 D+ D + L + G+L+ V Q L Sbjct: 93 DNPDVIFIGGGLTAPGVFAAAWKRLPVGGRLVANAVTVESEQML 136 >4XGI-A nrPDB Length = 436 Score = 33.1 bits (74), Expect = 0.21, Method: Composition-based stats. Identities = 11/48 (22%), Positives = 18/48 (37%) Query: 165 GVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISS 212 V G++ G R + G G VG + K+ + G V + Sbjct: 215 FVVGCEAAKKKGVEIEGARIAVQGFGNVGGIAAKLFQEAGAKVIAVQD 262 >5ZZ6-A nrPDB Length = 208 Score = 33.1 bits (74), Expect = 0.22, Method: Composition-based stats. Identities = 10/43 (23%), Positives = 22/43 (51%) Query: 302 SMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRY 344 ++ + E+ +F +E G+ + V ++ ERLEK ++ Sbjct: 130 TVSDVSELEKFVEEHGVEIGVIAVPAEHAQEIAERLEKAGIKG 172 >1ZFN-A nrPDB Length = 253 Score = 32.7 bits (73), Expect = 0.23, Method: Composition-based stats. Identities = 18/136 (13%), Positives = 33/136 (24%), Gaps = 31/136 (22%) Query: 182 LRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQD---LGADDYVIGSDQ--- 235 + I+GLGG+G G V++ + LQ +D Q Sbjct: 31 SQVLIIGLGGLGTPAALYLAGAGVGTLVLADDDDVHLSNLQRQILFTTEDIDRPKSQVSQ 90 Query: 236 ---------------------AKMSELADSLDYVIDTVPVHHALE----PYLSLLKLDGK 270 + + D V+D + ++L Sbjct: 91 QRLTQLNPDIQLTALQQRLTGEALKDAVARADVVLDCTDNMATRQEINAACVALNTPLIT 150 Query: 271 LILMGVINNPLQFLTP 286 +G + P Sbjct: 151 ASAVGFGGQLMVLTPP 166 >3PPI-A nrPDB Length = 281 Score = 32.7 bits (73), Expect = 0.25, Method: Composition-based stats. Identities = 21/136 (15%), Positives = 41/136 (30%), Gaps = 6/136 (4%) Query: 170 SPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLG---- 225 + + G GG+G V+ A G V + + +K + +LG Sbjct: 20 GSMVTIKQFEGASAIVSGGAGGLGEATVRRLHADGLGVVIADLAAEKGKALADELGNRAE 79 Query: 226 --ADDYVIGSDQAKMSELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQF 283 + + E A+ L + V H +++ DG MG + Sbjct: 80 FVSTNVTSEDSVLAAIEAANQLGRLRYAVVAHGGFGVAQRIVQRDGSPADMGGFTKTIDL 139 Query: 284 LTPLLMLGRKVITGSF 299 +++ S Sbjct: 140 YLNGTYNVARLVAASI 155 >5VMT-A nrPDB Length = 342 Score = 32.7 bits (73), Expect = 0.25, Method: Composition-based stats. Identities = 17/121 (14%), Positives = 41/121 (33%), Gaps = 24/121 (19%) Query: 183 RGGILGLGGVGHMGV-KIAKAMGHHVTVISS--------------SNKKREEALQDLGAD 227 + I G G +G + + +I KA G V ++ S + R + +L D Sbjct: 12 KVAINGFGRIGRLALRQIEKAHGIEVAAVNDLTPAEMLLHLFKYDSTQGRFQGTAELKDD 71 Query: 228 DYVIGSDQAKMSELAD---------SLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVIN 278 V+ + K+ + +D V++ + ++ + +++ Sbjct: 72 AIVVNGREIKVFANPNPEELPWGELGVDVVLECTGFFTNKTKAEAHIRAGARKVVISAPG 131 Query: 279 N 279 Sbjct: 132 G 132 >3NJ4-A nrPDB Length = 435 Score = 32.7 bits (73), Expect = 0.27, Method: Composition-based stats. Identities = 8/51 (15%), Positives = 15/51 (29%) Query: 173 SHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQD 223 + G + G G VG + + G V + +A + Sbjct: 208 RATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAME 258 >4OMU-A nrPDB Length = 283 Score = 32.7 bits (73), Expect = 0.28, Method: Composition-based stats. Identities = 23/120 (19%), Positives = 45/120 (37%), Gaps = 18/120 (15%) Query: 173 SHFGLKQPGLRGGILGLGGVGHMGVK-----IAKAMGHHVTVISSSNKKREEALQDLGAD 227 + G++ G R ILG GG V+ I + + + + +K E+ ++ Sbjct: 111 VNAGVELAGKRILILGAGG----AVRGVLEPILAHKPQSLVIANRTVEKAEQLAREF--- 163 Query: 228 DYVIGSDQAKMSELADSLDYVIDTVPVHHA--LEPYLSLLKLDGKLI----LMGVINNPL 281 D + + + L + +D +I+ A L P L G+ + + G P Sbjct: 164 DELGPVVASGFAWLQEPVDVIINATSASLAGELPPIADSLVEAGRTVCYDMMYGKEPTPF 223 >4E4T-A nrPDB Length = 419 Score = 32.3 bits (72), Expect = 0.30, Method: Composition-based stats. Identities = 24/101 (23%), Positives = 45/101 (44%), Gaps = 10/101 (9%) Query: 180 PGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGS--DQAK 237 PG G++G G +G M A++MG+ V V+ A+ AD ++ + D+A Sbjct: 34 PGAWLGMVGGGQLGRMFCFAAQSMGYRVAVLDPDPASPAGAV----ADRHLRAAYDDEAA 89 Query: 238 MSELADSLDYV---IDTVPVHH-ALEPYLSLLKLDGKLILM 274 ++ELA + V + VP + + G+ + + Sbjct: 90 LAELAGLCEAVSTEFENVPAASLDFLARTTFVAPAGRCVAV 130 >1CRW-G nrPDB Length = 333 Score = 32.3 bits (72), Expect = 0.34, Method: Composition-based stats. Identities = 17/126 (13%), Positives = 38/126 (30%), Gaps = 24/126 (19%) Query: 182 LRGGILGLGGVGHMGVKIAKAMGHHVTVISSS-----------------NKKREEALQDL 224 + GI G G +G + ++ A MG V ++ + E + Sbjct: 1 SKIGINGFGRIGRLVLRAALEMGAQVVAVNDPFIALEYMVYMFKYDSTHGMFKGEVKAED 60 Query: 225 GADDYV-------IGSDQAKMSELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVI 277 GA + +Y++++ V +E + K K +++ Sbjct: 61 GALVVDGKKITVFNEMKPENIPWSKAGAEYIVESTGVFTTIEKASAHFKGGAKKVIISAP 120 Query: 278 NNPLQF 283 + Sbjct: 121 SADAPM 126 >1EUZ-A nrPDB Length = 419 Score = 32.3 bits (72), Expect = 0.34, Method: Composition-based stats. Identities = 14/52 (26%), Positives = 22/52 (42%), Gaps = 1/52 (1%) Query: 164 AGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAK-AMGHHVTVISSSN 214 A T+ G+ G + + G G G+ K+AK +G V +S S Sbjct: 195 AIFTIREAAKALGIDLKGKKIAVQGYGNAGYYTAKLAKEQLGMTVVAVSDSR 246 >1ZEJ-A nrPDB Length = 293 Score = 32.3 bits (72), Expect = 0.35, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 31/71 (43%), Gaps = 4/71 (5%) Query: 183 RGGILGLGGVG-HMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL 241 + ++G G +G + + IA H V+ ++K EA ++ ++ + + E Sbjct: 14 KVFVIGAGLMGRGIAIAIA---SKHEVVLQDVSEKALEAAREQIPEELLSKIEFTTTLEK 70 Query: 242 ADSLDYVIDTV 252 D V++ V Sbjct: 71 VKDCDIVMEAV 81 >1XDW-A nrPDB Length = 331 Score = 31.9 bits (71), Expect = 0.40, Method: Composition-based stats. Identities = 10/37 (27%), Positives = 16/37 (43%) Query: 172 LSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVT 208 F + G++GLG +G + +I MG V Sbjct: 137 AFMFSKEVRNCTVGVVGLGRIGRVAAQIFHGMGATVI 173 >1HL3-A nrPDB Length = 358 Score = 31.9 bits (71), Expect = 0.42, Method: Composition-based stats. Identities = 13/28 (46%), Positives = 15/28 (53%) Query: 181 GLRGGILGLGGVGHMGVKIAKAMGHHVT 208 G GI+GLG VG AKA G +V Sbjct: 171 GETLGIIGLGRVGQAVALRAKAFGFNVL 198 >3OC4-A nrPDB Length = 452 Score = 31.9 bits (71), Expect = 0.44, Method: Composition-based stats. Identities = 14/88 (15%), Positives = 31/88 (35%), Gaps = 5/88 (5%) Query: 170 SPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSN---KKREEALQDLGA 226 L+ L + ++G G +G + M V V S K + +++ A Sbjct: 136 GALAAVPLLENSQTVAVIGAGPIGMEAIDFLVKMKKTVHVFESLENLLPKYFD--KEMVA 193 Query: 227 DDYVIGSDQAKMSELADSLDYVIDTVPV 254 + QA + +++ + +T Sbjct: 194 EVQKSLEKQAVIFHFEETVLGIEETANG 221 >2ZJ1-A nrPDB Length = 495 Score = 31.9 bits (71), Expect = 0.46, Method: Composition-based stats. Identities = 25/167 (14%), Positives = 48/167 (28%), Gaps = 39/167 (23%) Query: 180 PGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQ-AKM 238 G + I G G VG K EA++ GA V D + Sbjct: 274 GGKKVLICGYGDVG---------------------KGCAEAMKGQGARVSVTEIDPINAL 312 Query: 239 SELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGS 298 + + D V +E + D +++ N + L + + I G+ Sbjct: 313 QAMMEGFDVV--------TVEEAI----GDADIVVTATGNKDIIMLEHIKAMKDHAILGN 360 Query: 299 FIGSMKETEEMLEFCKEK----GLSSIIEVVKMDYVNTAFERLEKND 341 IG +M + + +++ + L + Sbjct: 361 -IGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGR 406 >3K92-A nrPDB Length = 424 Score = 31.9 bits (71), Expect = 0.49, Method: Composition-based stats. Identities = 24/152 (15%), Positives = 46/152 (30%), Gaps = 22/152 (14%) Query: 170 SPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSN-----------KKRE 218 + G+K R I G G G K G V IS +N Sbjct: 210 EAVKKKGIKLQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLL 269 Query: 219 EALQDLGA-----DDYVIGSDQAKMSELADSLDYVID---TVPVHHALEPYLSLLKLDG- 269 + G D + ++ + + I T H ++ + + + +G Sbjct: 270 DKRDSFGMVTNLFTDVITN-EELLEKDCDILVPAAISNQITAKNAHNIQASIVVERANGP 328 Query: 270 -KLILMGVINNPLQFLTPLLMLGRKVITGSFI 300 + ++N L P ++ +T S+ Sbjct: 329 TTIDATKILNERGVLLVPDILASAGGVTVSYF 360 >5T5Q-A nrPDB Length = 247 Score = 31.5 bits (70), Expect = 0.52, Method: Composition-based stats. Identities = 9/73 (12%), Positives = 27/73 (36%), Gaps = 2/73 (2%) Query: 184 GGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYV--IGSDQAKMSEL 241 GG+G ++ A G ++ + + + LG+ + + I +D + + Sbjct: 13 VLTGANGGIGRAIAELFHASGANLVLTDLDREGLDAFAASLGSPERIATIKADASSADDA 72 Query: 242 ADSLDYVIDTVPV 254 ++ ++ Sbjct: 73 EKTVALAMERFGG 85 >1VH3-A nrPDB Length = 262 Score = 31.5 bits (70), Expect = 0.53, Method: Composition-based stats. Identities = 8/46 (17%), Positives = 21/46 (45%), Gaps = 4/46 (8%) Query: 204 GHHVTVISSSNKKREEALQDLGADDYV----IGSDQAKMSELADSL 245 G +I++ N+ + + GA+ + S +++E+ + L Sbjct: 41 GASRVIIATDNENVADVAKSFGAEVCMTSVNHNSGTERLAEVVEKL 86 >5JFC-L nrPDB Length = 474 Score = 31.5 bits (70), Expect = 0.57, Method: Composition-based stats. Identities = 13/35 (37%), Positives = 20/35 (57%), Gaps = 2/35 (5%) Query: 176 GLKQPGLRGGILGLGGVGHM-GVKIAKAMGHHVTV 209 G+K+ G + I+G G G +AK MG+ VT+ Sbjct: 149 GIKRNGKKVAIIGAGPAGLTCAADLAK-MGYEVTI 182 >5U9P-A nrPDB Length = 265 Score = 31.5 bits (70), Expect = 0.60, Method: Composition-based stats. Identities = 13/89 (14%), Positives = 28/89 (31%), Gaps = 14/89 (15%) Query: 181 GLRGGILGLG-GVGHMGVKIAKAMGHHVTVISSSNKKREEALQD-----LGADDYVIGSD 234 G R I G G G+G + G + + + +K + AD V Sbjct: 20 GRRALITGSGRGIGLTLARGLAEAGAAIVINDRNEEKAATLARRFRDEGFAADHAVFDVA 79 Query: 235 Q--------AKMSELADSLDYVIDTVPVH 255 + + ++D +++ + Sbjct: 80 EHAQVRAAIDEFEARVGAIDILVNNAGIQ 108 >2O23-A nrPDB Length = 265 Score = 31.5 bits (70), Expect = 0.60, Method: Composition-based stats. Identities = 12/88 (13%), Positives = 26/88 (29%), Gaps = 10/88 (11%) Query: 184 GGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELA- 242 G G+G + G ++ N E + LG + +D ++ Sbjct: 16 VITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQT 75 Query: 243 ---------DSLDYVIDTVPVHHALEPY 261 +D ++ + A + Y Sbjct: 76 ALALAKGKFGRVDVAVNCAGIAVASKTY 103 >3EZY-A nrPDB Length = 344 Score = 31.5 bits (70), Expect = 0.62, Method: Composition-based stats. Identities = 19/92 (20%), Positives = 40/92 (43%), Gaps = 5/92 (5%) Query: 182 LRGGILGLGGVGHMGVKIAKAMGHHVT-VISSSNKKREEALQD-LGADDYVIGSDQAKMS 239 LR G++GLG +G + + K + + IS + R +++ LG + D ++ Sbjct: 3 LRIGVIGLGRIGTIHAENLKMIDDAILYAISDVREDRLREMKEKLGVEKAY--KDPHELI 60 Query: 240 ELADSLDYVIDTVPVHHALEPYLSLLKLDGKL 271 E + +D V+ + E ++ K + Sbjct: 61 EDPN-VDAVLVCSSTNTHSELVIACAKAKKHV 91 >6APH-A nrPDB Length = 445 Score = 31.5 bits (70), Expect = 0.62, Method: Composition-based stats. Identities = 18/92 (19%), Positives = 30/92 (32%), Gaps = 8/92 (8%) Query: 162 LCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEAL 221 C V + + G R + G G VG + G VTV +A Sbjct: 207 GCRESAVDAIRRATDVMLAGKRVVVCGFGDVGKGTAASFRGAGSIVTVTEIDPICALQAA 266 Query: 222 QDLGADDYVIGSDQAKMSELADSLDYVIDTVP 253 + G + ++ + D+ D +I T Sbjct: 267 ME--------GYEVKQLDTVVDNADIIITTTG 290 >3HWR-A nrPDB Length = 318 Score = 31.5 bits (70), Expect = 0.62, Method: Composition-based stats. Identities = 25/101 (24%), Positives = 44/101 (43%), Gaps = 10/101 (9%) Query: 181 GLRGGILGLGGVGH-MGVKIAKAMGHHVTVISSSNKKREEALQDLGAD-DYVIGSDQAKM 238 G++ I+G G VG G +A+A GH V +I+ + +A++ G + +Q K+ Sbjct: 19 GMKVAIMGAGAVGCYYGGMLARA-GHEVILIA--RPQHVQAIEATGLRLETQSFDEQVKV 75 Query: 239 SELAD-----SLDYVIDTVPVHHALEPYLSLLKLDGKLILM 274 S +D D V+ V L++ K L+ Sbjct: 76 SASSDPSAVQGADLVLFCVKSTDTQSAALAMKPALAKSALV 116 >5VJ7-A nrPDB Length = 476 Score = 31.5 bits (70), Expect = 0.64, Method: Composition-based stats. Identities = 13/35 (37%), Positives = 20/35 (57%), Gaps = 2/35 (5%) Query: 176 GLKQPGLRGGILGLGGVGHM-GVKIAKAMGHHVTV 209 G+K+ G + I+G G G +AK MG+ VT+ Sbjct: 149 GIKRNGKKVAIIGAGPAGLTCAADLAK-MGYEVTI 182 >4ZGS-A nrPDB Length = 386 Score = 31.1 bits (69), Expect = 0.66, Method: Composition-based stats. Identities = 13/53 (24%), Positives = 21/53 (39%) Query: 169 YSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEAL 221 YS G++ G++G G +G +I K +G V EA+ Sbjct: 166 YSLSGLVGVEMRHKVVGVVGTGAIGQQAARILKGIGCKVFAYDIKPNPAVEAM 218 >3L9X-A nrPDB Length = 413 Score = 31.1 bits (69), Expect = 0.68, Method: Composition-based stats. Identities = 15/90 (16%), Positives = 34/90 (37%), Gaps = 3/90 (3%) Query: 181 GLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSE 240 G+R I G G G + ++ + G + V+ + E L+ G + + + + E Sbjct: 4 GMRVIIAGFGRFGQITGRLLLSSGVKMVVL-DHDPDHIETLRKFGMKVFYGDATRMDLLE 62 Query: 241 LAD--SLDYVIDTVPVHHALEPYLSLLKLD 268 A + +I+ + ++K Sbjct: 63 SAGAAKAEVLINAIDDPQTNLQLTEMVKEH 92 >6ER9-A nrPDB Length = 549 Score = 31.1 bits (69), Expect = 0.85, Method: Composition-based stats. Identities = 13/63 (20%), Positives = 21/63 (33%), Gaps = 5/63 (7%) Query: 136 AKATVVHQKFVVKIP-EGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGH 194 AK V + I + G T+++ G G R G++G G G Sbjct: 137 AKYVVNAVGLLSAINFPDLP----GLDTFEGETIHTAAWPEGKNLAGKRVGVIGTGSTGQ 192 Query: 195 MGV 197 + Sbjct: 193 QVI 195 >1NVM-B nrPDB Length = 312 Score = 30.7 bits (68), Expect = 0.86, Method: Composition-based stats. Identities = 20/97 (20%), Positives = 33/97 (34%), Gaps = 6/97 (6%) Query: 182 LRGGILGLGGVG--HM--GVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAK 237 L+ I+G G +G M ++ AK + V + Q +G G + Sbjct: 5 LKVAIIGSGNIGTDLMIKVLRNAKYLEMGAMVGIDAASDGLARAQRMGVTTTYAGVEGLI 64 Query: 238 MSELADSLDYVIDTVPVHHAL--EPYLSLLKLDGKLI 272 +D+V D + E L K +LI Sbjct: 65 KLPEFADIDFVFDATSASAHVQNEALLRQAKPGIRLI 101 >5UOG-A nrPDB Length = 344 Score = 30.7 bits (68), Expect = 0.95, Method: Composition-based stats. Identities = 26/136 (19%), Positives = 51/136 (37%), Gaps = 18/136 (13%) Query: 181 GLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSE 240 G G+ GLG +G + +A G + + + ++ LG + + Sbjct: 164 GRTVGLFGLGRIGLAIARRLEAFGVSIAYHTRTPRE------GLGFTYHPT------LVG 211 Query: 241 LADSLDYVIDTVPVHHALEPY-----LSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVI 295 +A+++D +I VP + LS L G LI +G + + + L I Sbjct: 212 MAEAVDTLIVIVPGTASTLKAVNADVLSALGPKGVLINVGRGSTVDEA-ALVTALQNGTI 270 Query: 296 TGSFIGSMKETEEMLE 311 G+ + + + E Sbjct: 271 AGAGLDVFENEPNVPE 286 >1NYT-A nrPDB Length = 271 Score = 30.7 bits (68), Expect = 0.99, Method: Composition-based stats. Identities = 23/105 (21%), Positives = 39/105 (37%), Gaps = 6/105 (5%) Query: 153 MAVEQAAPLLC--AGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVI 210 M +E L GV + S L +PGLR ++G GG + ++ VT+ Sbjct: 89 MRLEDGRLLGDNTDGVGLLSDLERLSFIRPGLRILLIGAGGASRGVLLPLLSLDCAVTIT 148 Query: 211 SSSNKKREEALQDLGADDYVIGSDQAKMSELAD-SLDYVIDTVPV 254 + + + EE + + M EL D +I+ Sbjct: 149 NRTVSRAEELAKLF---AHTGSIQALSMDELEGHEFDLIINATSS 190 >4DGS-A nrPDB Length = 340 Score = 30.7 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 25/126 (19%), Positives = 42/126 (33%), Gaps = 12/126 (9%) Query: 175 FGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSD 234 G G R G+LGLG +G A+A G V R L D++ Sbjct: 165 LGHSPKGKRIGVLGLGQIGRALASRAEAFGMSV---------RYWNRSTLSGVDWIAHQS 215 Query: 235 QAKMSELADSLDYVIDTVPVHHALEPY--LSLLKLDGKLILMGVINNPLQFLTPLLMLGR 292 ++ +D L + + L L +G ++ + N + + L Sbjct: 216 PVDLARDSDVLAVCVAASAATQNIVDASLLQALGPEGIVVNV-ARGNVVDEDALIEALKS 274 Query: 293 KVITGS 298 I G+ Sbjct: 275 GTIAGA 280 Score = 28.0 bits (61), Expect = 5.7, Method: Composition-based stats. Identities = 16/77 (20%), Positives = 28/77 (36%), Gaps = 3/77 (3%) Query: 137 KATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMG 196 +V P +E A P + A T + GI+ + GVG Sbjct: 50 NYSVHRLYQAADRPA---LEAALPSIRAVATGGGAGLSNEWMEKLPSLGIIAINGVGTDK 106 Query: 197 VKIAKAMGHHVTVISSS 213 V +A+A ++ V ++ Sbjct: 107 VDLARARRRNIDVTTTP 123 >1QP8-A nrPDB Length = 303 Score = 30.7 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 20/95 (21%), Positives = 36/95 (37%), Gaps = 8/95 (8%) Query: 181 GLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSE 240 G + +LGLG +G KI A+G V S + K+ G + ++A Sbjct: 124 GEKVAVLGLGEIGTRVGKILAALGAQVRGFSRTPKE--------GPWRFTNSLEEALREA 175 Query: 241 LADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMG 275 A ++ +L+L+ D + +G Sbjct: 176 RAAVCALPLNKHTRGLVKYQHLALMAEDAVFVNVG 210 >4XIJ-A nrPDB Length = 275 Score = 30.7 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 10/55 (18%), Positives = 19/55 (34%), Gaps = 4/55 (7%) Query: 176 GLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKR----EEALQDLGA 226 L G ++G GG V +G I + ++ + + + GA Sbjct: 121 ALGTAGDSALVIGSGGTAPAAVVALAELGVQRITIVARDEGKASRLVDLARRCGA 175 >3DC2-A nrPDB Length = 529 Score = 30.4 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 19/42 (45%) Query: 168 VYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTV 209 + S G + G G++GLG +G + + A G +V Sbjct: 129 TWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVA 170 >6GBN-A nrPDB Length = 438 Score = 30.4 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 17/97 (17%), Positives = 27/97 (27%), Gaps = 8/97 (8%) Query: 162 LCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEAL 221 C V S + G + G G VG + G V V +A Sbjct: 200 GCKESLVDSIRRATDVMMAGKVAVVAGYGDVGKGSAASLRGAGARVIVTEIDPICALQAA 259 Query: 222 QDLGADDYVIGSDQAKMSELADSLDYVIDTVPVHHAL 258 G + KM++ D V+ + + Sbjct: 260 M--------DGYEVKKMADAVKRADIVVTATGNKNII 288 >3K8Z-A nrPDB Length = 423 Score = 30.4 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 14/44 (31%) Query: 170 SPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSS 213 G+ G R + G G G K G V IS + Sbjct: 209 EAAKKRGIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDA 252 >1OBF-O nrPDB Length = 335 Score = 30.4 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 12/83 (14%), Positives = 30/83 (36%), Gaps = 8/83 (9%) Query: 232 GSDQAKMSELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLG 291 + A++ A +D V++ E + +K K +++ + Sbjct: 79 NRNPAQLPWGALKVDVVLECTGFFTTKEKAGAHIKGGAKKVIISAPGGAD--------VD 130 Query: 292 RKVITGSFIGSMKETEEMLEFCK 314 V+ G G++K T+ ++ Sbjct: 131 ATVVYGVNHGTLKSTDTVISNAS 153 >4RG3-A nrPDB Length = 548 Score = 30.4 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 13/63 (20%), Positives = 21/63 (33%), Gaps = 5/63 (7%) Query: 136 AKATVVHQKFVVKIP-EGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGH 194 AK V + I + G T+++ G G R G++G G G Sbjct: 144 AKYVVNAVGLLSAINFPNLP----GLDTFEGETIHTAAWPEGKSLAGRRVGVIGTGSTGQ 199 Query: 195 MGV 197 + Sbjct: 200 QVI 202 >4PZE-A nrPDB Length = 284 Score = 30.4 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 13/64 (20%), Positives = 23/64 (35%), Gaps = 5/64 (7%) Query: 183 RGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELA 242 GI+G G +G+ + +G +V ++ S +A G D+ E Sbjct: 5 TVGIVGAGTMGNGIAQACAVVGLNVVMVDIS-----DAAVQKGVATVASSLDRLIKKEKL 59 Query: 243 DSLD 246 D Sbjct: 60 TEAD 63 >3ZH3-A nrPDB Length = 419 Score = 30.0 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 19/85 (22%), Positives = 33/85 (38%), Gaps = 5/85 (5%) Query: 218 EEALQDLGADDYVIGSDQAKMSELADSLDYV---IDTVPVHHALEPYLSLLKLDGKLILM 274 +A + +GA G D K+S L +DTV V + ++ +K +G+ I+ Sbjct: 127 LKAFEAMGATASYEG-DNMKLSAKDTGLHGASIYMDTVSVGATINTMIAAVKANGRTIIE 185 Query: 275 GVINNPLQFLTPLLMLG-RKVITGS 298 P L+ I G+ Sbjct: 186 NAAREPEIIDVATLLNNMGAHIRGA 210 >4DNX-A nrPDB Length = 397 Score = 30.0 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 15/83 (18%), Positives = 30/83 (36%), Gaps = 10/83 (12%) Query: 222 QDLGADDYVIGSDQAKMSELADSLDY--VIDTVPVHHAL------EPYLSLLKLDGKLIL 273 Q++GA ++IG D A + + D + D L + K G++++ Sbjct: 285 QNMGATHFIIGRDHAGVGDYYGPFDAQTIFDDAVPTDVLAIEIFRADNTAYSKKLGRVVM 344 Query: 274 MGVINNPLQFLTPLLMLGRKVIT 296 M + P + L + Sbjct: 345 M--RDAPDHTPDDFIQLSGTRVR 365 >6ACF-A nrPDB Length = 367 Score = 30.0 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 13/86 (15%), Positives = 33/86 (38%), Gaps = 9/86 (10%) Query: 153 MAVEQAAPLLCAGVT---VYSPLSHFGLKQPGLRGG---ILGLGGVGHMGVKIAKAM--- 203 ++ E + + T VY + + G ++ + GVG++ + + + Sbjct: 136 ISPEFGSSGNPSPATAYGVYRGMKAAAKEAFGSDSLEGKVVAVQGVGNVAYHLCRHLHEE 195 Query: 204 GHHVTVISSSNKKREEALQDLGADDY 229 G + V + + A+++ GA Sbjct: 196 GAKLIVTDINKEAVARAVEEFGAKAV 221 >3H9U-A nrPDB Length = 436 Score = 30.0 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 17/109 (15%), Positives = 30/109 (27%), Gaps = 7/109 (6%) Query: 160 PLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREE 219 C V + G + G G VG + G V V + Sbjct: 190 LYGCRESLVDGIKRATDVMIAGKTACVCGYGDVGKGCAAALRGFGARVVVTEVDPINALQ 249 Query: 220 ALQD----LGADDYVIGSDQAKMSELADSLDYVIDTVPVHHALEPYLSL 264 A + L +D V ++A + D +I + + + Sbjct: 250 AAMEGYQVLLVEDVV---EEAHIFVTTTGNDDIITSEHFPRMRDDAIVC 295 >4AEC-A nrPDB Length = 430 Score = 30.0 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 14/94 (14%), Positives = 35/94 (37%), Gaps = 10/94 (10%) Query: 174 HFGLKQPGLRGGI---LGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYV 230 G PG + G G+G + ++ +T+ +S + +R L+ GA+ + Sbjct: 167 QKGFISPGKSVLVEPTSGNTGIGLAFIAASRGYRLILTMPASMSMERRVLLKAFGAELVL 226 Query: 231 IGSDQAKMSELADSLDY---VIDTVPVHHALEPY 261 + ++ ++ P + L+ + Sbjct: 227 T----DPAKGMTGAVQKAEEILKNTPDAYMLQQF 256 >5F8E-A nrPDB Length = 377 Score = 30.0 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 19/106 (17%), Positives = 35/106 (33%), Gaps = 11/106 (10%) Query: 179 QPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEA----LQDLG-ADDYVIGS 233 + G G G G +A+A G + + A LG A+ Sbjct: 186 RSGADVADFGCGS-GRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERH 244 Query: 234 DQAKMSELADS-----LDYVIDTVPVHHALEPYLSLLKLDGKLILM 274 D A++ ++ D + D L+ L+ G L+++ Sbjct: 245 DLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMV 290 >3G1U-A nrPDB Length = 437 Score = 30.0 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 12/64 (18%), Positives = 17/64 (26%) Query: 160 PLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREE 219 C V + G + G G VG +A G V V + Sbjct: 191 LYGCRESLVDGIKRATDVMIAGKTCCVCGYGDVGKGCAAALRAFGARVVVTEVDPINALQ 250 Query: 220 ALQD 223 A + Sbjct: 251 ASME 254 >3N58-A nrPDB Length = 464 Score = 30.0 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 20/150 (13%), Positives = 44/150 (29%), Gaps = 13/150 (8%) Query: 162 LCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEAL 221 C V + G + G G VG + G V V +A Sbjct: 228 GCKESLVDGIRRGTDVMMAGKVAVVCGYGDVGKGSAQSLAGAGARVKVTEVDPICALQAA 287 Query: 222 QDLGADDYVIGSDQAKMSELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPL 281 G + + + A + D V+ T + + ++ + ++G I Sbjct: 288 M--------DGFEVVTLDDAASTADIVVTTTGNKDVIT--IDHMRKMKDMCIVGNIG--- 334 Query: 282 QFLTPLLMLGRKVITGSFIGSMKETEEMLE 311 F + + + + + + + E + Sbjct: 335 HFDNEIQVAALRNLKWTNVKPQVDLIEFPD 364 >2ILV-A nrPDB Length = 400 Score = 30.0 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 11/61 (18%), Positives = 18/61 (29%) Query: 124 VYINGQPTQGGFAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLR 183 +Y G P G + + K + IP ++ E V S P + Sbjct: 283 IYFKGHPRGGEINDYILNNAKNITNIPANISFEVLMMTGLLPDKVGGVASSLYFSLPKEK 342 Query: 184 G 184 Sbjct: 343 I 343 >4S1V-D nrPDB Length = 332 Score = 30.0 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 21/96 (21%), Positives = 36/96 (37%), Gaps = 7/96 (7%) Query: 175 FGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSD 234 G G GI GLG +G + G ++ ++ + +LG Y +D Sbjct: 141 LGRTLSGRTLGIWGLGKIGQRIAQFGHVFGM--PILVWGSEASRQKALELG---YQAAAD 195 Query: 235 QAKMSELAD--SLDYVIDTVPVHHALEPYLSLLKLD 268 +A+ AD SL ++ + L +K D Sbjct: 196 KAEFFAKADVLSLHLRLNDATRGIVTKQDLLAMKPD 231 >3K2C-A nrPDB Length = 193 Score = 30.0 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 8/22 (36%), Positives = 14/22 (63%) Query: 1 MGIMEAERKTTGWAARDPSGIL 22 MG +EA+ + G A++ SG + Sbjct: 9 MGTLEAQTQGPGSMAKEASGNV 30 >4K2X-A nrPDB Length = 523 Score = 30.0 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 11/64 (17%), Positives = 20/64 (31%), Gaps = 3/64 (4%) Query: 184 GGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELAD 243 I G G G M + G T++ + + + LG + + M L + Sbjct: 25 VVIAGAGPTGLMLACELRLAGA-RTLVLERLAEPVDFSKALG--VHARTVELLDMRGLGE 81 Query: 244 SLDY 247 Sbjct: 82 GFQA 85 >3OH0-A nrPDB Length = 641 Score = 29.6 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 15/87 (17%), Positives = 32/87 (36%), Gaps = 8/87 (9%) Query: 115 PKKIWSYNDVYINGQPTQGGFAKATVVHQKFVVKIPEGMAVE--QAAPLLCAGVTVY-SP 171 ++I D+Y+ GG A+ + + + E + + PL+ +++ Sbjct: 39 ERQIALLTDLYMFSNMYPGGVAQYIRNGHELLARESEEVDFAALEMPPLIFEAPSLHRRT 98 Query: 172 LSHFGLKQPG-----LRGGILGLGGVG 193 L+ G +L GG+G Sbjct: 99 AERTALENAGTAMLCKTVFVLVAGGLG 125 >6DEB-A nrPDB Length = 285 Score = 29.6 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 21/105 (20%), Positives = 35/105 (33%), Gaps = 8/105 (7%) Query: 152 GMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGG-VGH-MGVKIAKAMGHHVTV 209 + +E L C + V L + + G I+G VG M + A G V+V Sbjct: 132 NLGLESG-FLPCTPLGVMKLLKAYEIDLEGKDAVIIGASNIVGRPMATMLLNA-GATVSV 189 Query: 210 I----SSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDYVID 250 + +A + A V + E +D I+ Sbjct: 190 CHIKTKDLSLYTRQADLIIVAAGCVNLLRSDMVKEGVIVVDVGIN 234 >5NC8-A nrPDB Length = 237 Score = 29.6 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 13/89 (14%), Positives = 38/89 (42%), Gaps = 2/89 (2%) Query: 178 KQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAK 237 + I G G G + ++ A G+H++++ + + + L+ G + + + Sbjct: 24 IEATNSVIIAGYGRFGQVVGRLLSAQGYHLSIL-DHSPSQIDMLRRFGNKVFYGDAARKD 82 Query: 238 MSELADSLDYVIDTVPVHHALEPYLSLLK 266 + E A + D + + + + L +++ Sbjct: 83 LLEAAGAKDAQLLVIAIDAP-DKALEIVE 110 >3TQD-A nrPDB Length = 256 Score = 29.6 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 16/65 (24%), Positives = 29/65 (44%), Gaps = 8/65 (12%) Query: 204 GHHVTVISSSNKKREEALQDLGADDYVIGSDQ----AKMSELADSL----DYVIDTVPVH 255 G VI++ +K+ + +D GA + SD +++E A +L D +I + Sbjct: 48 GAEEVVIATDDKRIRQVAEDFGAVVCMTSSDHQSGTERIAEAAVALGFEDDEIIVCLQGD 107 Query: 256 HALEP 260 L P Sbjct: 108 EPLIP 112 >2EFY-A nrPDB Length = 304 Score = 29.6 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 13/76 (17%), Positives = 36/76 (47%), Gaps = 4/76 (5%) Query: 174 HFGLKQPGLRGGIL----GLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDY 229 G+ +PG I+ G G+G + ++ +T+ + +++R+ L+ GA+ Sbjct: 53 ERGILRPGSGQVIVEPTSGNTGIGLAMIAASRGYRLILTMPAQMSEERKRVLKAFGAELV 112 Query: 230 VIGSDQAKMSELADSL 245 + ++ ++ ++L Sbjct: 113 LTDPERRMLAAREEAL 128 >1F14-A nrPDB Length = 310 Score = 29.6 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 12/69 (17%), Positives = 28/69 (40%), Gaps = 2/69 (2%) Query: 182 LRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL 241 ++G G +G ++A A G H V+ + + G ++ + + K +E Sbjct: 16 KHVTVIGGGLMGAGIAQVAAATG-HTVVLVDQTEDILAKSKK-GIEESLRKVAKKKFAEN 73 Query: 242 ADSLDYVID 250 + D ++ Sbjct: 74 PKAGDECVE 82 >2B4Q-A nrPDB Length = 276 Score = 29.6 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 9/48 (18%), Positives = 16/48 (33%), Gaps = 1/48 (2%) Query: 180 PGLRGGILGLG-GVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGA 226 G + G G+G M + G V + + + + L A Sbjct: 28 AGRIALVTGGSRGIGQMIAQGLLEAGARVFICARDAEACADTATRLSA 75 >1JWB-B nrPDB Length = 249 Score = 29.6 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 8/23 (34%), Positives = 12/23 (52%) Query: 182 LRGGILGLGGVGHMGVKIAKAMG 204 R I+GLGG+G + + G Sbjct: 32 SRVLIVGLGGLGCAASQYLASAG 54 >5JXW-A nrPDB Length = 498 Score = 29.6 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 13/35 (37%) Query: 180 PGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSN 214 G + +LG G VG + +G V V Sbjct: 270 AGKKIVVLGYGEVGKGCAQGLSGVGARVIVTEIDP 304 >5TSD-A nrPDB Length = 322 Score = 29.6 bits (65), Expect = 2.3, Method: Composition-based stats. Identities = 10/37 (27%), Positives = 16/37 (43%) Query: 172 LSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVT 208 + + G++GLG +G V K MG +V Sbjct: 133 AKLIAPEAAEVTVGVMGLGILGQDAVAKLKVMGFNVI 169 >1B26-A nrPDB Length = 416 Score = 29.6 bits (65), Expect = 2.4, Method: Composition-based stats. Identities = 32/205 (15%), Positives = 65/205 (31%), Gaps = 48/205 (23%) Query: 163 CAGVTVYSPLSHFGLKQPGLRGGILGLGGVGH-MGVKIAKAMGHHVTVISSSN------- 214 CAG+ + G+ + G G VG + I++ +G V +S S Sbjct: 196 CAGL----AMDVLGIDPKKATVAVQGFGNVGQFAALLISQELGSKVVAVSDSRGGIYNPE 251 Query: 215 ----KKREEALQDLGADDYVIGSDQAKMSELADSLDYVIDTVPVHHALEPYL---SLLKL 267 ++ ++ G + +E LD I V ALE + + ++ Sbjct: 252 GFDVEELIRYKKEHG-TVVTYPKGERITNEELLELDVDI---LVPAALEGAIHAGNAERI 307 Query: 268 DGKLILMGVINNPLQ-----------FLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEK 316 K ++ G + P ++ +T S+ +++ + Sbjct: 308 KAKAVVEGANGPTTPEADEILSRRGILVVPDILANAGGVTVSYFEWVQDLQSFF------ 361 Query: 317 GLSSIIEVVKMDYVNTAFERLEKND 341 +D V A E++ K Sbjct: 362 --------WDLDQVRNALEKMMKGA 378 >4PRK-A nrPDB Length = 336 Score = 29.2 bits (64), Expect = 2.5, Method: Composition-based stats. Identities = 9/33 (27%), Positives = 14/33 (42%) Query: 181 GLRGGILGLGGVGHMGVKIAKAMGHHVTVISSS 213 G++G+G +G +I AMG V Sbjct: 146 NKTIGLIGVGHIGSAVAQIFSAMGAKVLAYDVI 178 >3HDH-A nrPDB Length = 302 Score = 29.2 bits (64), Expect = 2.6, Method: Composition-based stats. Identities = 12/69 (17%), Positives = 28/69 (40%), Gaps = 2/69 (2%) Query: 182 LRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSEL 241 ++G G +G ++A A G H V+ + + G ++ + + K +E Sbjct: 16 KHVTVIGGGLMGAGIAQVAAATG-HTVVLVDQTEDILAKSKK-GIEESLRKVAKKKFAEN 73 Query: 242 ADSLDYVID 250 + D ++ Sbjct: 74 PKAGDEFVE 82 >3OND-A nrPDB Length = 488 Score = 29.2 bits (64), Expect = 2.6, Method: Composition-based stats. Identities = 9/45 (20%), Positives = 12/45 (26%) Query: 170 SPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSN 214 + + G + G G VG K G V V Sbjct: 254 GLMRATDVMIAGKVAVVAGYGDVGKGCAAALKQAGARVIVTEIDP 298 >5FUB-A nrPDB Length = 337 Score = 29.2 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 15/65 (23%), Positives = 28/65 (43%), Gaps = 1/65 (1%) Query: 187 LGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYV-IGSDQAKMSELADSL 245 G G + +AK G + SS + EE ++ G D V + ++A+ L + Sbjct: 53 CGTGVISLFCALLAKPAGVYAVEASSMAEHTEELVKQNGCDGVVTVFQERAENLTLPTKV 112 Query: 246 DYVID 250 D ++ Sbjct: 113 DVLVS 117 >1BW9-B nrPDB Length = 356 Score = 29.2 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 13/51 (25%), Positives = 20/51 (39%), Gaps = 1/51 (1%) Query: 181 GLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVI 231 GL + GLG VG +A G + V ++ +R LG + Sbjct: 176 GLTVLVQGLGAVGGSLASLAAEAGAQLLVA-DTDTERVAHAVALGHTAVAL 225 >6DLL-A nrPDB Length = 398 Score = 29.2 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 13/98 (13%), Positives = 34/98 (34%), Gaps = 5/98 (5%) Query: 183 RGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKK----REEA-LQDLGADDYVIGSDQAK 237 + I+G G G + ++ G ++ + R A + + G D + + A+ Sbjct: 7 QVAIIGAGPSGLLLGQLLHKAGIDNIIVERQTAEYVLGRIRAGVLEQGTVDLLREAGVAE 66 Query: 238 MSELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMG 275 + + ++ + L L +++ G Sbjct: 67 RMDREGLVHEGVELLVGGRRQRLDLKALTGGKTVMVYG 104 >1LQU-A nrPDB Length = 456 Score = 29.2 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 26/156 (16%), Positives = 46/156 (29%), Gaps = 21/156 (13%) Query: 115 PKKIWSYNDVYINGQPTQ-GGFAK------ATV-VHQKFVVKIP-EGMAVEQAAPLLCAG 165 + + + G+ Q G ++ V ++ IP E + AA Sbjct: 72 EDPRFRFFGNVVVGEHVQPGELSERYDAVIYAVGAQSDRMLNIPGEDLPGSIAAVDFVGW 131 Query: 166 VTVYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLG 225 + G R ++G G V +I V + E+L+ G Sbjct: 132 YNAHPHFEQVSPDLSGARAVVIGNGNVALDVARIL-LTDPDVLARTDIADHALESLRPRG 190 Query: 226 ADDYVIGSDQAKMSELA-----------DSLDYVID 250 + VI + + D +D VID Sbjct: 191 IQEVVIVGRRGPLQAAFTTLELRELADLDGVDVVID 226 >6HNS-A nrPDB Length = 454 Score = 29.2 bits (64), Expect = 3.0, Method: Composition-based stats. Identities = 8/28 (28%), Positives = 11/28 (39%), Gaps = 3/28 (10%) Query: 183 RGGILGLGGVGHM---GVKIAKAMGHHV 207 R I+G G G + A A G + Sbjct: 4 RVAIIGAGPCGLAQLRAFQSAAAKGAAI 31 >5DSE-A nrPDB Length = 837 Score = 29.2 bits (64), Expect = 3.0, Method: Composition-based stats. Identities = 18/119 (15%), Positives = 36/119 (30%), Gaps = 12/119 (10%) Query: 14 AARDPSGILSPYTYTLRETGPEDVNIRIICCGICHTDLHQTKNDLGMSNYPMVPGHEVVG 73 AA + + +R P+D I ++ +C LH + + Sbjct: 403 AAGKSARAVKVLKECIR-LKPDDATIPLLAAKLCMGSLHWLEEAEKFAK----------- 450 Query: 74 EVVEVGSDVSKFTVGDIVGVGCLVGCCGGCSPCERDLEQYCPKKIWSYNDVYINGQPTQ 132 VV+VG S+F + +G + E K + ++ + Sbjct: 451 TVVDVGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDH 509 >2YQ5-A nrPDB Length = 343 Score = 29.2 bits (64), Expect = 3.0, Method: Composition-based stats. Identities = 10/29 (34%), Positives = 15/29 (51%) Query: 181 GLRGGILGLGGVGHMGVKIAKAMGHHVTV 209 L G++G+G +G +I AMG V Sbjct: 148 NLTVGLIGVGHIGSAVAEIFSAMGAKVIA 176 >4E6P-A nrPDB Length = 259 Score = 29.2 bits (64), Expect = 3.0, Method: Composition-based stats. Identities = 11/75 (14%), Positives = 26/75 (34%), Gaps = 1/75 (1%) Query: 181 GLRGGILG-LGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMS 239 G I G G+G + G V + ++ +A ++G Y + D + Sbjct: 8 GKSALITGSARGIGRAFAEAYVREGATVAIADIDIERARQAAAEIGPAAYAVQMDVTRQD 67 Query: 240 ELADSLDYVIDTVPV 254 + ++ ++ Sbjct: 68 SIDAAIAATVEHAGG 82 >1QO8-A nrPDB Length = 566 Score = 29.2 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 7/32 (21%), Positives = 14/32 (43%) Query: 183 RGGILGLGGVGHMGVKIAKAMGHHVTVISSSN 214 + ++G G G AK G +V ++ + Sbjct: 123 QVLVVGAGSAGFNASLAAKKAGANVILVDKAP 154 >3VZS-A nrPDB Length = 257 Score = 28.8 bits (63), Expect = 3.3, Method: Composition-based stats. Identities = 16/81 (19%), Positives = 26/81 (32%), Gaps = 14/81 (17%) Query: 188 GLGGVGHMGVKIAKAMGHHVTVISSSNKKREEA----LQDLG----------ADDYVIGS 233 G+GG+G + G V N R E + LG AD + Sbjct: 22 GMGGIGTAICQRLAKDGFRVVAGCGPNSPRREKWLEQQKALGFDFIASEGNVADWDSTKT 81 Query: 234 DQAKMSELADSLDYVIDTVPV 254 K+ +D +I+ + Sbjct: 82 AFDKVKSEVGEVDVLINNAGI 102 >3FBT-A nrPDB Length = 282 Score = 28.8 bits (63), Expect = 3.3, Method: Composition-based stats. Identities = 19/148 (12%), Positives = 52/148 (35%), Gaps = 30/148 (20%) Query: 170 SPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKR------------ 217 LS F ++ +LG GG ++ K + + N ++ Sbjct: 111 KMLSKFRVEIKNNICVVLGSGGAARAVLQYLKDNFAKDIYVVTRNPEKTSEIYGEFKVIS 170 Query: 218 EEALQDLGADDYVI-------------GSDQAKMSELADSLDYV---IDTVPVHHALEPY 261 + L +L D + D+ +++ + ++D + ++T+ + +A E Sbjct: 171 YDELSNLKGDVIINCTPKGMYPKEGESPVDKEVVAKFSSAVDLIYNPVETLFLKYARESG 230 Query: 262 LSLLKLDGKLILMGVINNPLQFLTPLLM 289 + + +G +L+ + + + Sbjct: 231 VKAV--NGLYMLVSQAAASEEIWNDISI 256 >3F9I-A nrPDB Length = 249 Score = 28.8 bits (63), Expect = 3.4, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 20/50 (40%), Gaps = 5/50 (10%) Query: 177 LKQPGLRGGILGLG-GVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLG 225 + G I G G+G ++ +G V + + EE L+ LG Sbjct: 10 IDLTGKTSLITGASSGIGSAIARLLHKLGSKVII----SGSNEEKLKSLG 55 >4G2N-A nrPDB Length = 345 Score = 28.8 bits (63), Expect = 3.5, Method: Composition-based stats. Identities = 22/110 (20%), Positives = 40/110 (36%), Gaps = 13/110 (11%) Query: 168 VYSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGAD 227 + P G+ G R GI G+G +G A+ G I N+ R + GA Sbjct: 160 GWGPTQLLGMGLTGRRLGIFGMGRIGRAIATRARGFG---LAIHYHNRTRLSHALEEGAI 216 Query: 228 DYVIGSDQAKMSELADSLDYVIDTVPVHHALEPYLSLLK----LDGKLIL 273 + + L + D + P L+ +L + +G +++ Sbjct: 217 YH------DTLDSLLGASDIFLIAAPGRPELKGFLDHDRIAKIPEGAVVI 260 >4BOY-A nrPDB Length = 354 Score = 28.8 bits (63), Expect = 3.8, Method: Composition-based stats. Identities = 11/55 (20%), Positives = 18/55 (32%) Query: 226 ADDYVIGSDQAKMSELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNP 280 A V + + A +D VI+ V + E L K +L+ Sbjct: 91 AVKCVSDRNPENLPWSAWGIDLVIEATGVFTSREGASKHLSAGAKKVLITAPGKG 145 >4X28-D nrPDB Length = 373 Score = 28.8 bits (63), Expect = 3.8, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 20/58 (34%), Gaps = 3/58 (5%) Query: 159 APLLCAGVTVYSPLSHFGLKQPGLRG---GILGLGGVGHMGVKIAKAMGHHVTVISSS 213 A L+ A + + PG+ GLG VGH+ + AK + Sbjct: 160 AFLVPAETDSGAAVFLVAAGDPGVAVTALATTGLGSVGHLELNGAKVDAARRVGGTDV 217 >4CQM-B nrPDB Length = 244 Score = 28.8 bits (63), Expect = 3.9, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 28/65 (43%), Gaps = 1/65 (1%) Query: 182 LRGGILGLG-GVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSE 240 + G G+G ++ G+ + VI+ + + + A DLG D D AK + Sbjct: 10 KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHD 69 Query: 241 LADSL 245 + ++ Sbjct: 70 VQNTF 74 >5M6D-A nrPDB Length = 355 Score = 28.8 bits (63), Expect = 4.1, Method: Composition-based stats. Identities = 7/47 (14%), Positives = 16/47 (34%) Query: 233 SDQAKMSELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINN 279 D ++ D ++ V++ E LK K +++ Sbjct: 98 RDPEQIDWATDGVEIVLEATGFFAKKEAAEKHLKGGAKKVVITAPGG 144 >3BA1-A nrPDB Length = 333 Score = 28.8 bits (63), Expect = 4.1, Method: Composition-based stats. Identities = 24/122 (19%), Positives = 42/122 (34%), Gaps = 17/122 (13%) Query: 178 KQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAK 237 K G R GI+GLG +G + A+A ++ S S K + Sbjct: 161 KFSGKRVGIIGLGRIGLAVAERAEAFDCPISYFSRSKKPN------------TNYTYYGS 208 Query: 238 MSELADSLD-YVIDTVPVHHAL----EPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGR 292 + ELA + D V+ + L G LI +G + + ++ Sbjct: 209 VVELASNSDILVVACPLTPETTHIINREVIDALGPKGVLINIGRGPHVDEPELVSALVEG 268 Query: 293 KV 294 ++ Sbjct: 269 RL 270 >6C2H-A nrPDB Length = 375 Score = 28.4 bits (62), Expect = 4.5, Method: Composition-based stats. Identities = 30/162 (18%), Positives = 57/162 (35%), Gaps = 11/162 (6%) Query: 187 LGLGGVGHMGVKIAKAMGHHVTVISSSNK---KREEALQDLGADDYVIGSDQAKMS-ELA 242 G G+G + K + T+I+ K ++ L+ LGA+ + A S E Sbjct: 104 SGNTGIGLALIGAIK---GYRTIITLPEKMSNEKVSVLKALGAEIIRTPTAAAWDSPESH 160 Query: 243 DSLDYVID-TVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLGRKVITGSFIG 301 + ++ +P L+ Y +++ + G L R V+ G+ G Sbjct: 161 IGVAKKLEKEIPGAVILDQYNNMMNPEAHYFGTGREIQRQLEDLNLFDNLRAVVAGAGTG 220 Query: 302 SMKETEEMLEFCKEKGLSSIIEVV-KMDYVNTAFERLEKNDV 342 + ++ KE+ I + E L K D+ Sbjct: 221 GT--ISGISKYLKEQNDKIQIVGADPFGSILAQPENLNKTDI 260 >6F73-A nrPDB Length = 574 Score = 28.4 bits (62), Expect = 4.7, Method: Composition-based stats. Identities = 7/53 (13%), Positives = 21/53 (39%), Gaps = 7/53 (13%) Query: 300 IGSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFERLEKNDVRYRFVVDVEG 352 + + + L+F ++ + +I+ NT + L K+ + + + Sbjct: 130 VTGAADVQAALKFAQKHNVRIVIK-------NTGHDYLGKSTGKGALSLWMHN 175 >5ITV-A nrPDB Length = 255 Score = 28.4 bits (62), Expect = 5.1, Method: Composition-based stats. Identities = 25/165 (15%), Positives = 52/165 (31%), Gaps = 17/165 (10%) Query: 182 LRGGILG-LGGVGHMGVKIAKAMGHHVTVISSS-----------NKKREEALQDLGADDY 229 I G G+G+ V+ +V V N R +Q D+ Sbjct: 8 KTVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGEAMVRKENNDRLHFVQTDITDEA 67 Query: 230 VIGSDQAKMSELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILM---GVINNPLQFLTP 286 LD +I+ + + L K++ + G+ L Sbjct: 68 ACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELSDWNKVLQVNLTGMFLMSKHALKH 127 Query: 287 LLMLG-RKVITGSFIGSMKETEEMLEF-CKEKGLSSIIEVVKMDY 329 +L G +I +G + ++ + + G+ + + + +DY Sbjct: 128 MLAAGKGNIINTCSVGGLVAWPDIPAYNASKGGVLQLTKSMAVDY 172 >6JDK-A nrPDB Length = 544 Score = 28.4 bits (62), Expect = 5.5, Method: Composition-based stats. Identities = 12/37 (32%), Positives = 16/37 (43%) Query: 174 HFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVI 210 G G R G++G G G V+ A H+TV Sbjct: 179 QEGASFTGKRVGVVGTGASGVQVVQEASKDAAHLTVF 215 >4LMA-A nrPDB Length = 326 Score = 28.4 bits (62), Expect = 5.5, Method: Composition-based stats. Identities = 16/91 (17%), Positives = 33/91 (36%), Gaps = 4/91 (4%) Query: 174 HFGLKQPGLRGGI---LGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYV 230 GL P + G G+ AK +T+ + + +R L+ GA + Sbjct: 66 KAGLINPETTVLVEPTSGNTGIALAMTAAAKGYRLILTMPETMSLERRAMLKAYGATLEL 125 Query: 231 IGSDQAKMSELADSLDYVIDTVPVHHALEPY 261 Q + ++D++P + L+ + Sbjct: 126 TPGSQGMKGAILR-AQQIVDSIPGAYMLQQF 155 >2WUG-A nrPDB Length = 291 Score = 28.4 bits (62), Expect = 5.5, Method: Composition-based stats. Identities = 13/68 (19%), Positives = 25/68 (36%), Gaps = 1/68 (1%) Query: 245 LDYVIDTVPVHHALEPYLSLLKLDGKLILMGVINNPLQFLTPLLMLG-RKVITGSFIGSM 303 + V + + A+ L G+L+LMG + P G +++ S + Sbjct: 108 VPLVGNALGGGTAVRFALDYPARAGRLVLMGPGGLSINLFAPDPTEGVKRLSKFSVAPTR 167 Query: 304 KETEEMLE 311 + E L Sbjct: 168 ENLEAFLR 175 >1YQG-A nrPDB Length = 263 Score = 28.0 bits (61), Expect = 5.5, Method: Composition-based stats. Identities = 19/89 (21%), Positives = 36/89 (40%), Gaps = 13/89 (14%) Query: 189 LGGVGHMGVKIA----KAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADS 244 LGG G+M +A K G+ + + + +KRE ++LG + + Sbjct: 6 LGG-GNMAAAVAGGLVKQGGYRIYIANRGAEKRERLEKELGVETSATLPELHS------- 57 Query: 245 LDYVIDTVPVHHALEPYLSLLKLDGKLIL 273 D V+ +E ++ +G L+L Sbjct: 58 -DDVLILAVKPQDMEAACKNIRTNGALVL 85 >6MVR-A nrPDB Length = 767 Score = 28.0 bits (61), Expect = 5.8, Method: Composition-based stats. Identities = 24/116 (20%), Positives = 37/116 (31%), Gaps = 13/116 (11%) Query: 146 VVKIPEGMAVEQAAPLLCAGVTVYSPL-----SHFGLKQPGLRGGILGLGGVGHMGV--K 198 KI +A+ L A T + L G+ + G G VG M V + Sbjct: 173 AWKIAPALAMGNTVVLKPAEWTPLTALLFADICGQAGVPAGVVNIVTGDGAVGEMIVTAQ 232 Query: 199 IAK-AMGHHVTVISSSNKKREEALQDL-----GADDYVIGSDQAKMSELADSLDYV 248 + K A V + + L G YV+ D S + +D + Sbjct: 233 VDKVAFTGSTAVGRRIREATAGTGKALSLELGGKGPYVVCDDADIDSAVEGLVDAI 288 >3GBX-A nrPDB Length = 420 Score = 28.0 bits (61), Expect = 5.8, Method: Composition-based stats. Identities = 18/109 (16%), Positives = 33/109 (30%), Gaps = 8/109 (7%) Query: 222 QDLGADDYVIGSDQAKMSELAD--SLDYVIDT--VPVHHALEPYLSLLKLDGKLILMGVI 277 + G +YV +Q + + DY Y +LL+ ++ M + Sbjct: 66 RYYGGCEYVDVVEQLAIDRAKELFGADYANVQPHSGSQANFAVYTALLQPGDTVLGMNLA 125 Query: 278 NNPLQFLTPLLMLGRKVITGSFIG----SMKETEEMLEFCKEKGLSSII 322 + K+ G + +EM + KE II Sbjct: 126 QGGHLTHGSPVNFSGKLYNIVPYGIDESGKIDYDEMAKLAKEHKPKMII 174 >1LTH-T nrPDB Length = 319 Score = 28.0 bits (61), Expect = 5.9, Method: Composition-based stats. Identities = 11/39 (28%), Positives = 16/39 (41%), Gaps = 1/39 (2%) Query: 183 RGGILGLGGVGHMGVKIAKAMG-HHVTVISSSNKKREEA 220 + ++G G VG A G V+ K+R EA Sbjct: 9 KLAVIGAGAVGSTLAFAAAQRGIAREIVLEDIAKERVEA 47 >5TX7-A nrPDB Length = 327 Score = 28.0 bits (61), Expect = 6.1, Method: Composition-based stats. Identities = 37/178 (20%), Positives = 62/178 (34%), Gaps = 23/178 (12%) Query: 181 GLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSN--KKREEALQDLGADDYVIGSDQAKM 238 G GI+G G G +IA A+G +V + + + +G D+ +D + Sbjct: 148 GKTMGIVGFGNTGRRVGRIANALGMNVIAYAPRSRFDPDYRPFEHVGLDELFTSADVVSL 207 Query: 239 -----SELADSLD-----------YVIDTVPVHHALEPYLSLLKLDGKLILMG---VINN 279 E +D Y+I+T E ++ G+L G + Sbjct: 208 HCPLTPETEGLVDARRLASMRPGSYLINTARGPLLDERAVAEALDSGRLAGAGLDVLSQE 267 Query: 280 PLQFLTPLLMLGRKVITGSF-IGSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFER 336 P PLL +IT S +++ + S IE ++ VN A R Sbjct: 268 PPAADNPLLSAKNCLITPHLAWASRTARRTLMDSTAA-NIRSFIEGTPVNVVNAAHLR 324 >3K8D-A nrPDB Length = 264 Score = 28.0 bits (61), Expect = 6.1, Method: Composition-based stats. Identities = 14/99 (14%), Positives = 35/99 (35%), Gaps = 8/99 (8%) Query: 171 PLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYV 230 P + + PG + + ++ A+ G ++++ ++ A++ G + + Sbjct: 24 PARYASTRLPGKPLVDINGKPMIVHVLERARESGAERIIVATDHEDVARAVEAAGGEVCM 83 Query: 231 IGSDQAKMSELADSL--------DYVIDTVPVHHALEPY 261 +D +E + D VI V + P Sbjct: 84 TRADHQSGTERLAEVVEKCAFSDDTVIVNVQGDEPMIPA 122 >2ISQ-A nrPDB Length = 320 Score = 28.0 bits (61), Expect = 6.2, Method: Composition-based stats. Identities = 17/73 (23%), Positives = 27/73 (36%), Gaps = 3/73 (4%) Query: 174 HFGLKQPGLRGGI---LGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYV 230 GL +PG I G GVG AK +T+ +S + +R L G + + Sbjct: 57 KKGLIKPGESVLIEPTSGNTGVGLAFTAAAKGYKLIITMPASMSTERRIILLAFGVELVL 116 Query: 231 IGSDQAKMSELAD 243 + +A Sbjct: 117 TDPAKGMKGAIAK 129 >5TEN-A nrPDB Length = 269 Score = 28.0 bits (61), Expect = 6.4, Method: Composition-based stats. Identities = 23/101 (22%), Positives = 39/101 (38%), Gaps = 7/101 (6%) Query: 184 GGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEA------LQDLGADDYVIGSDQAK 237 I G G MG + KA H+ ++ +R E+ L +L + Sbjct: 2 VRIAVAGAAGRMGRNLVKAAHHNPVAKVAAGSERPESSLVGVDLGELCGEGKFDVVVCDD 61 Query: 238 MSELADSLDYVIDTVPVHHALEPYLSLLKLDGKLILMGVIN 278 +++ D D +ID L L+L + GK I++G Sbjct: 62 LAKQIDQFDVIIDFTAPASTLN-NLALCQQYGKSIVIGTTG 101 >3U5T-A nrPDB Length = 267 Score = 28.0 bits (61), Expect = 6.4, Method: Composition-based stats. Identities = 29/129 (22%), Positives = 47/129 (36%), Gaps = 24/129 (18%) Query: 158 AAPLLCAGVTV---YSPLSHFGLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSN 214 AA L G TV Y+ + + G I GG KA+ V + Sbjct: 44 AARLASDGFTVVINYAGKAAAAEEVAGK---IEAAGG---------KALTAQADVSDPAA 91 Query: 215 KKREEALQDL---GADDYVIGSDQAKMSELADSLDYVIDTV------PVHHALEPYLSLL 265 +R A + G D V + ++ +A++ D V D V + L L Sbjct: 92 VRRLFATAEEAFGGVDVLVNNAGIMPLTTIAETGDAVFDRVIAVNLKGTFNTLREAAQRL 151 Query: 266 KLDGKLILM 274 ++ G++I M Sbjct: 152 RVGGRIINM 160 >4LMB-A nrPDB Length = 322 Score = 28.0 bits (61), Expect = 6.8, Method: Composition-based stats. Identities = 26/125 (20%), Positives = 49/125 (39%), Gaps = 8/125 (6%) Query: 141 VHQKFVVKIPEGMAVEQAAPLLC-AGVTVYSPLSHFGLKQPGLRGGI---LGLGGVGHMG 196 V + VVK+ E M AA + GV++ GL P + G G+ Sbjct: 35 VKARIVVKL-ESMNP--AASVKDRIGVSMVEDAEAAGLIHPDKTILVEPTSGNTGIALAM 91 Query: 197 VKIAKAMGHHVTVISSSNKKREEALQDLGADDYVIGSDQAKMSELADSLDYVIDTVPVHH 256 V AK +T+ + + +R L+ GA + Q + + +++ P + Sbjct: 92 VAAAKGYRLVLTMPETMSLERRAMLKAYGAQLELTPGSQGMEGAITR-AEEIVENTPNAY 150 Query: 257 ALEPY 261 +L+ + Sbjct: 151 SLQQF 155 >3X43-A nrPDB Length = 332 Score = 28.0 bits (61), Expect = 6.9, Method: Composition-based stats. Identities = 12/59 (20%), Positives = 23/59 (38%), Gaps = 2/59 (3%) Query: 176 GLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVI--SSSNKKREEALQDLGADDYVIG 232 GL +PG G VG +A A G+ + + + +R + ++ G + Sbjct: 58 GLLKPGDTIVECTSGNVGIALAMVAAARGYRFVAVMGDTYSVERRKLIRAYGGKLVLFP 116 >1LU9-A nrPDB Length = 287 Score = 27.7 bits (60), Expect = 7.2, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 23/79 (29%), Gaps = 5/79 (6%) Query: 176 GLKQPGLRGGILGLGGVGHMGVKIAKAMGHHVTVISSSNKKREEALQDLGADDYVI---- 231 G + + G G VG + G V + K + A + V Sbjct: 115 GSVKGKKAVVLAGTGPVGMRSAALLAGEGAEVVLCGRKLDKAQAAADSVNKRFKVNVTAA 174 Query: 232 -GSDQAKMSELADSLDYVI 249 +D A +E +V Sbjct: 175 ETADDASRAEAVKGAHFVF 193 >1V47-A nrPDB Length = 349 Score = 27.7 bits (60), Expect = 7.7, Method: Composition-based stats. Identities = 21/112 (18%), Positives = 32/112 (28%), Gaps = 26/112 (23%) Query: 135 FAKATVVHQKFVVKIPEGMAVEQAAPLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGH 194 A +VH K P+ E V Y L P R GL Sbjct: 181 LADGVLVHPILGAKKPDDFPTEVI-------VEAYQALIR--DFLPQERVAFFGL----- 226 Query: 195 MGVKIAKAMGHHVTVISSSNKKREEAL--QDLGADDYVIGSDQAKMSELADS 244 + + AL ++ GA +++G D A + + D Sbjct: 227 ----------ATPMRYAGPKEAVFHALVRKNFGATHFLVGRDHAGVGDFYDP 268 >4NPH-A nrPDB Length = 351 Score = 27.7 bits (60), Expect = 8.3, Method: Composition-based stats. Identities = 14/81 (17%), Positives = 23/81 (28%), Gaps = 4/81 (4%) Query: 143 QKFVVKIPEGMAVEQAA--PLLCAGVTVYSPLSHFGLKQPGLRGGILGLGGVGHMGV--K 198 K + M P+ +T + G R GI GVG + Sbjct: 27 PDVCWKDYDAMPPPAMVRQPITQPLMTGIRAIDSVATCGEGQRVGIFSAPGVGKSTLLAM 86 Query: 199 IAKAMGHHVTVISSSNKKREE 219 + A V+ ++ E Sbjct: 87 LCNAPDADSNVLVLIGERGRE 107 >4ZV2-A nrPDB Length = 233 Score = 27.7 bits (60), Expect = 8.4, Method: Composition-based stats. Identities = 24/128 (18%), Positives = 48/128 (37%), Gaps = 14/128 (10%) Query: 221 LQDLGADDYVIGSDQAKMSEL--ADSLDYVIDTVPVHHALEPYLSLLKL---DGKLILMG 275 + LG D + + +D VI + + + + G+ I++ Sbjct: 44 AKKLGVKVEFKPMDFDGIIPALQSGKIDVVIAGMTITEERKKQVDFSDPYFEAGQAIVVK 103 Query: 276 VINNPLQFLTPLLMLGRKVITGSFIGSMKETEEMLEFCKEKGLSSIIEVVKMDYVNTAFE 335 N+ ++ L L K + G +GS E + K+ + ++V K D + AF+ Sbjct: 104 KGNDSIKSLED---LKGKKV-GVQLGSTSE-----QHVKKVAKDAGVKVKKFDNFSEAFQ 154 Query: 336 RLEKNDVR 343 L+ V Sbjct: 155 ELKSGRVD 162 >5ZBK-A nrPDB Length = 203 Score = 27.3 bits (59), Expect = 9.9, Method: Composition-based stats. Identities = 30/146 (20%), Positives = 46/146 (31%), Gaps = 21/146 (14%) Query: 159 APLLCAGVTVYSPLSHFGLKQPGLRGG------ILGLGGVGHMGVKIAKAMGHHVTVISS 212 + C SP+ G + G G VG MG A+ VI Sbjct: 6 VCVFCGASPGASPVYQEAAVALGRHLAERGLTLVYGGGAVGLMGTVADAALAAGGEVIGI 65 Query: 213 SNKKREEALQDLGADDY----VIGSDQAKMSELADSLDYVIDTVPVHHALEPYLSL---- 264 + +EA ++G V+ A+ + +A+ D I LE + Sbjct: 66 IPQSLQEA--EIGHKGLTRLEVVDGMHARKARMAELADAFIALPGGLGTLEALFEVWTWG 123 Query: 265 -----LKLDGKLILMGVINNPLQFLT 285 K G L + G + L FL Sbjct: 124 QLGYHAKPLGLLEVNGFYDPLLTFLD 149 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.139 0.370 Lambda K H 0.267 0.0424 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,204,054 Number of Sequences: 36641 Number of extensions: 603923 Number of successful extensions: 3630 Number of sequences better than 10.0: 304 Number of HSP's better than 10.0 without gapping: 290 Number of HSP's successfully gapped in prelim test: 139 Number of HSP's that attempted gapping in prelim test: 2702 Number of HSP's gapped (non-prelim): 477 length of query: 357 length of database: 10,336,785 effective HSP length: 98 effective length of query: 259 effective length of database: 6,745,967 effective search space: 1747205453 effective search space used: 1747205453 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 60 (27.7 bits)