BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= O48814 (395 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5TOS-A nrPDB 818 0.0 6J5U-C nrPDB 430 e-121 3UIM-A nrPDB 215 3e-56 5XD6-A nrPDB 210 9e-55 5LPZ-A nrPDB 205 2e-53 6CTH-A nrPDB 200 1e-51 5LPV-A nrPDB 199 1e-51 2QKW-B nrPDB 184 8e-47 5UIU-A nrPDB 176 2e-44 6BFN-A nrPDB 155 3e-38 4I94-A nrPDB 154 5e-38 4L68-A nrPDB 145 4e-35 6J6I-B nrPDB 127 8e-30 3PPZ-A nrPDB 115 4e-26 5HLW-A nrPDB 107 8e-24 4GS6-A nrPDB 106 2e-23 3C1X-A nrPDB 106 2e-23 3QGY-A nrPDB 105 4e-23 5HVK-A nrPDB 103 9e-23 4UYA-A nrPDB 103 1e-22 4UY9-A nrPDB 103 1e-22 4F0G-A nrPDB 102 3e-22 5WNL-A nrPDB 100 9e-22 6DBM-A nrPDB 100 2e-21 4OLI-A nrPDB 100 2e-21 4P5Q-A nrPDB 99 2e-21 3SXS-A nrPDB 99 3e-21 3DTC-A nrPDB 99 3e-21 5UV4-A nrPDB 99 4e-21 4TPT-A nrPDB 98 7e-21 6EAS-A nrPDB 97 1e-20 1AD5-A nrPDB 96 2e-20 3BEA-A nrPDB 96 3e-20 6FEX-A nrPDB 95 4e-20 4E93-A nrPDB 95 6e-20 4CSV-A nrPDB 94 7e-20 3ZBF-A nrPDB 94 1e-19 4PDO-A nrPDB 94 1e-19 3COM-A nrPDB 94 1e-19 4E20-A nrPDB 93 2e-19 6BSD-A nrPDB 93 3e-19 1JPA-A nrPDB 92 3e-19 5X5O-A nrPDB 92 4e-19 2OGV-A nrPDB 92 4e-19 2VWV-A nrPDB 91 1e-18 4XCU-A nrPDB 90 1e-18 4NEU-A nrPDB 90 2e-18 4YFF-A nrPDB 89 2e-18 5VO2-A nrPDB 89 3e-18 4R7H-A nrPDB 89 3e-18 2H8H-A nrPDB 89 3e-18 2HK5-A nrPDB 89 3e-18 3I81-A nrPDB 89 3e-18 6FER-A nrPDB 89 3e-18 5L6P-A nrPDB 89 4e-18 3DKO-A nrPDB 89 4e-18 2R2P-A nrPDB 89 4e-18 5H2U-A nrPDB 88 5e-18 6AO5-A nrPDB 88 6e-18 5AMN-A nrPDB 88 7e-18 2PL0-A nrPDB 88 7e-18 3KUL-B nrPDB 88 7e-18 4XLV-A nrPDB 88 7e-18 6F3F-A nrPDB 88 8e-18 4LG4-A nrPDB 87 1e-17 2Y6O-A nrPDB 87 1e-17 3OMV-A nrPDB 87 1e-17 5MJB-A nrPDB 86 2e-17 3V5Q-A nrPDB 86 2e-17 3PLS-A nrPDB 86 2e-17 2Z7Q-A nrPDB 86 2e-17 5U6C-A nrPDB 86 3e-17 3IO7-A nrPDB 86 3e-17 5KMM-A nrPDB 86 3e-17 1K9A-A nrPDB 86 3e-17 4XUF-A nrPDB 86 3e-17 1FVR-A nrPDB 86 4e-17 6GQK-A nrPDB 86 4e-17 2W1I-A nrPDB 86 4e-17 3KRL-A nrPDB 85 4e-17 5X02-A nrPDB 85 5e-17 1BYG-A nrPDB 85 5e-17 2BPM-A nrPDB 85 5e-17 5SYS-A nrPDB 85 5e-17 4EQM-A nrPDB 85 6e-17 5HIE-A nrPDB 85 7e-17 4QMW-A nrPDB 84 8e-17 4M66-A nrPDB 84 1e-16 1U54-B nrPDB 84 1e-16 5HI2-A nrPDB 84 1e-16 4HZS-A nrPDB 83 2e-16 4XEY-B nrPDB 83 2e-16 3A4O-X nrPDB 83 2e-16 4H1J-A nrPDB 83 2e-16 5FM2-A nrPDB 83 2e-16 4RA4-A nrPDB 83 2e-16 4KIK-B nrPDB 83 2e-16 6NPU-A nrPDB 82 3e-16 2PSQ-A nrPDB 82 4e-16 4HVI-A nrPDB 82 4e-16 4AT3-A nrPDB 82 4e-16 1FOT-A nrPDB 82 5e-16 3QA8-A nrPDB 82 5e-16 2FO0-A nrPDB 81 6e-16 3GQL-A nrPDB 81 7e-16 3CJF-A nrPDB 81 7e-16 3BBT-B nrPDB 81 7e-16 5A46-A nrPDB 81 8e-16 1U5R-A nrPDB 81 8e-16 2GCD-A nrPDB 81 9e-16 4L42-A nrPDB 80 1e-15 3AOX-A nrPDB 80 1e-15 5F9E-A nrPDB 80 1e-15 3TT0-A nrPDB 80 1e-15 5EG3-A nrPDB 80 1e-15 5U6B-A nrPDB 80 1e-15 4APC-A nrPDB 80 2e-15 5KKR-C nrPDB 80 2e-15 3G0E-A nrPDB 80 2e-15 4RLP-A nrPDB 80 2e-15 3EQC-A nrPDB 79 3e-15 4AN9-A nrPDB 79 3e-15 2DQ7-X nrPDB 79 3e-15 6GU6-A nrPDB 79 3e-15 2XIK-A nrPDB 79 4e-15 4TNB-A nrPDB 79 5e-15 4FL3-A nrPDB 78 5e-15 5AR8-A nrPDB 78 6e-15 3PFQ-A nrPDB 78 7e-15 2XYN-A nrPDB 78 8e-15 6DBN-A nrPDB 78 8e-15 5C26-A nrPDB 77 9e-15 2I0E-A nrPDB 77 9e-15 3NIZ-A nrPDB 77 1e-14 3PP0-A nrPDB 77 1e-14 4FZF-B nrPDB 77 1e-14 1LUF-A nrPDB 77 1e-14 2WQN-A nrPDB 77 1e-14 4Y93-A nrPDB 77 2e-14 3QUP-A nrPDB 77 2e-14 5XZW-A nrPDB 76 2e-14 5D9K-A nrPDB 76 2e-14 4JXF-A nrPDB 76 2e-14 3Q53-A nrPDB 76 3e-14 6FD3-A nrPDB 76 3e-14 4K33-A nrPDB 75 4e-14 4EBW-A nrPDB 75 5e-14 4WNO-A nrPDB 75 5e-14 2JDO-A nrPDB 75 5e-14 5KCV-A nrPDB 75 5e-14 2J0K-A nrPDB 75 6e-14 4BBM-A nrPDB 75 6e-14 6QAU-A nrPDB 75 6e-14 4MVF-A nrPDB 74 9e-14 3TXO-A nrPDB 74 1e-13 3LMG-A nrPDB 74 1e-13 3DAK-A nrPDB 74 1e-13 2A1A-B nrPDB 74 2e-13 5O2C-A nrPDB 73 2e-13 2UV2-A nrPDB 73 2e-13 4KRC-A nrPDB 73 2e-13 4FG9-A nrPDB 73 2e-13 2F57-A nrPDB 73 2e-13 3PVW-A nrPDB 73 2e-13 5E8V-A nrPDB 73 2e-13 5UUU-A nrPDB 73 2e-13 6HXF-B nrPDB 73 3e-13 1S9I-A nrPDB 73 3e-13 4CFF-A nrPDB 73 3e-13 1U59-A nrPDB 73 3e-13 3MV5-A nrPDB 72 3e-13 4FIE-A nrPDB 72 3e-13 3REP-A nrPDB 72 3e-13 4XI2-A nrPDB 72 3e-13 6E4F-A nrPDB 72 3e-13 5O2B-A nrPDB 72 4e-13 5JN2-A nrPDB 72 4e-13 5TQX-A nrPDB 72 4e-13 2XNP-A nrPDB 72 4e-13 5EZV-A nrPDB 72 4e-13 5DBX-A nrPDB 72 4e-13 4XBR-A nrPDB 72 4e-13 3ZZW-A nrPDB 72 4e-13 2Q0N-A nrPDB 72 5e-13 3ORP-A nrPDB 72 5e-13 4JDH-A nrPDB 72 5e-13 3A8W-A nrPDB 72 5e-13 3Q5I-A nrPDB 72 6e-13 6FDY-U nrPDB 71 6e-13 4PWN-A nrPDB 71 6e-13 4REW-A nrPDB 71 7e-13 3NYO-A nrPDB 71 7e-13 4AGU-A nrPDB 71 8e-13 4UZD-A nrPDB 71 8e-13 5ES1-A nrPDB 71 9e-13 6C9D-A nrPDB 71 1e-12 2OZO-A nrPDB 71 1e-12 3HDN-A nrPDB 71 1e-12 4RED-A nrPDB 71 1e-12 4PDS-A nrPDB 70 1e-12 4B8L-A nrPDB 70 1e-12 3UIU-A nrPDB 70 2e-12 4CFH-A nrPDB 70 2e-12 5KZ7-A nrPDB 70 2e-12 3MN3-A nrPDB 70 2e-12 1VZO-A nrPDB 70 2e-12 3MA6-A nrPDB 70 2e-12 3OZ6-A nrPDB 69 2e-12 4KS7-A nrPDB 69 2e-12 2HAK-A nrPDB 69 2e-12 5GRN-A nrPDB 69 3e-12 4M69-B nrPDB 69 3e-12 2QNJ-A nrPDB 69 3e-12 3LZB-A nrPDB 69 3e-12 3DB8-A nrPDB 69 3e-12 5GNK-A nrPDB 69 3e-12 3ALO-A nrPDB 69 3e-12 2BRG-A nrPDB 69 4e-12 4EWQ-A nrPDB 69 4e-12 1UA2-A nrPDB 69 4e-12 5C01-A nrPDB 69 4e-12 4MWI-A nrPDB 69 5e-12 2YZA-A nrPDB 69 5e-12 2QLU-A nrPDB 69 5e-12 4IDT-A nrPDB 69 5e-12 5NGU-A nrPDB 69 5e-12 3ZDU-A nrPDB 69 5e-12 3OHT-A nrPDB 68 5e-12 4BTF-A nrPDB 68 6e-12 2OU7-A nrPDB 68 7e-12 1G3N-A nrPDB 68 8e-12 3E3P-A nrPDB 68 9e-12 5USZ-A nrPDB 67 9e-12 4J52-A nrPDB 67 1e-11 1PY5-A nrPDB 67 1e-11 3D2K-A nrPDB 67 1e-11 4D28-A nrPDB 67 1e-11 3GC9-A nrPDB 67 2e-11 2W96-B nrPDB 67 2e-11 3SOC-A nrPDB 67 2e-11 4WOV-A nrPDB 67 2e-11 5B2L-A nrPDB 67 2e-11 2JC6-A nrPDB 66 2e-11 6BDL-A nrPDB 66 2e-11 2Y7J-A nrPDB 66 3e-11 4L00-A nrPDB 66 3e-11 5WNO-A nrPDB 66 3e-11 4QTB-A nrPDB 66 3e-11 3H4J-B nrPDB 65 4e-11 4OTD-A nrPDB 65 4e-11 5X3F-B nrPDB 65 4e-11 3ORZ-A nrPDB 65 4e-11 4AU8-A nrPDB 65 5e-11 4WB7-A nrPDB 65 5e-11 5J0A-A nrPDB 65 5e-11 5AIR-A nrPDB 65 6e-11 4AF3-A nrPDB 65 6e-11 3C51-A nrPDB 65 7e-11 4I6B-A nrPDB 64 8e-11 6CMJ-A nrPDB 64 9e-11 5YV8-A nrPDB 64 9e-11 2W4O-A nrPDB 64 1e-10 4X3F-A nrPDB 64 1e-10 4CQG-A nrPDB 64 1e-10 4YNZ-A nrPDB 64 1e-10 4YHJ-A nrPDB 64 1e-10 4OW8-A nrPDB 64 1e-10 6E9W-A nrPDB 64 1e-10 1PHK-A nrPDB 64 1e-10 4LRM-A nrPDB 64 1e-10 5JZN-A nrPDB 64 1e-10 4G3E-A nrPDB 64 2e-10 4M7I-A nrPDB 64 2e-10 3NCG-A nrPDB 63 2e-10 5J5T-A nrPDB 63 2e-10 5N23-A nrPDB 63 3e-10 6B2Q-A nrPDB 63 3e-10 5D7A-A nrPDB 62 3e-10 2X4F-A nrPDB 62 3e-10 3DFA-A nrPDB 62 3e-10 6CCF-A nrPDB 62 4e-10 4FR4-A nrPDB 62 4e-10 4E7W-A nrPDB 62 4e-10 3HZT-A nrPDB 62 4e-10 3DXN-A nrPDB 62 4e-10 5IG1-A nrPDB 62 5e-10 4MYG-A nrPDB 62 5e-10 2JAM-A nrPDB 62 5e-10 3HNG-A nrPDB 62 6e-10 6DTL-A nrPDB 62 6e-10 4Y83-A nrPDB 61 7e-10 5EFQ-A nrPDB 61 8e-10 3IS5-A nrPDB 61 9e-10 5G6V-A nrPDB 61 1e-09 3G2F-A nrPDB 61 1e-09 4QNY-A nrPDB 61 1e-09 1CM8-A nrPDB 61 1e-09 4RGJ-A nrPDB 60 1e-09 3VHK-A nrPDB 60 1e-09 2F9G-A nrPDB 60 2e-09 4D2V-A nrPDB 60 2e-09 4CZT-A nrPDB 60 2e-09 2BUJ-A nrPDB 60 2e-09 1KOB-A nrPDB 60 2e-09 3LIJ-A nrPDB 60 2e-09 4YZB-A nrPDB 60 2e-09 2YCR-A nrPDB 60 2e-09 6CQF-A nrPDB 60 2e-09 5Z33-A nrPDB 59 3e-09 1V0B-A nrPDB 59 3e-09 1ZXE-A nrPDB 59 3e-09 5FET-A nrPDB 59 3e-09 3KN6-A nrPDB 59 3e-09 5U6Y-A nrPDB 59 3e-09 5O0Y-A nrPDB 59 4e-09 4RT7-A nrPDB 59 4e-09 3SOA-A nrPDB 59 5e-09 3I6U-A nrPDB 59 5e-09 2VZ6-A nrPDB 58 6e-09 3VN9-A nrPDB 58 6e-09 6ED6-A nrPDB 58 6e-09 4B6L-A nrPDB 58 7e-09 4CRS-A nrPDB 58 7e-09 4U41-A nrPDB 58 8e-09 5DYK-A nrPDB 58 9e-09 4BGQ-A nrPDB 57 1e-08 2BDW-A nrPDB 57 1e-08 6CKI-A nrPDB 57 1e-08 4X7Q-B nrPDB 57 2e-08 6E2O-A nrPDB 57 2e-08 2V7O-A nrPDB 57 2e-08 4IC8-A nrPDB 57 2e-08 4JLC-A nrPDB 57 2e-08 4ZSG-A nrPDB 56 2e-08 2H34-A nrPDB 56 2e-08 4NST-A nrPDB 56 2e-08 3KK8-A nrPDB 56 2e-08 4NIF-A nrPDB 56 3e-08 4C0T-A nrPDB 56 3e-08 6NT9-A nrPDB 55 5e-08 3BHH-A nrPDB 55 5e-08 5FG8-A nrPDB 55 5e-08 3MIA-A nrPDB 55 6e-08 1KOA-A nrPDB 55 6e-08 3MDY-A nrPDB 55 8e-08 4AW2-A nrPDB 54 9e-08 3UTO-A nrPDB 54 9e-08 4EUT-A nrPDB 54 1e-07 6BXI-A nrPDB 54 1e-07 3MY0-A nrPDB 54 1e-07 2PMN-X nrPDB 54 1e-07 5WAX-A nrPDB 54 1e-07 2J90-A nrPDB 54 1e-07 5LOH-A nrPDB 54 1e-07 4EUU-A nrPDB 54 2e-07 3FME-A nrPDB 53 2e-07 6O8B-A nrPDB 53 2e-07 4PL5-B nrPDB 53 2e-07 5AWM-A nrPDB 53 3e-07 3F3Z-A nrPDB 52 3e-07 3TKU-A nrPDB 52 4e-07 2YAB-A nrPDB 52 4e-07 4C59-A nrPDB 52 4e-07 2HW6-A nrPDB 52 4e-07 4JG6-A nrPDB 52 5e-07 5IKW-A nrPDB 52 5e-07 3UC3-A nrPDB 52 5e-07 3E7O-A nrPDB 52 5e-07 2XS0-A nrPDB 52 5e-07 3Q4U-A nrPDB 52 6e-07 2RIO-A nrPDB 52 6e-07 3UDB-A nrPDB 52 6e-07 6HV0-A nrPDB 51 7e-07 3TAC-A nrPDB 51 7e-07 3QD2-B nrPDB 51 7e-07 1JNK-A nrPDB 51 9e-07 3FI2-A nrPDB 51 1e-06 6GVJ-A nrPDB 51 1e-06 4CRL-A nrPDB 50 1e-06 3GUB-A nrPDB 50 1e-06 2VN9-A nrPDB 50 2e-06 3GC0-A nrPDB 50 2e-06 3LM0-A nrPDB 50 2e-06 5TE0-A nrPDB 49 3e-06 3FXW-A nrPDB 49 3e-06 2I6L-A nrPDB 49 3e-06 5TUR-A nrPDB 49 4e-06 3DLS-A nrPDB 49 5e-06 3ZUT-A nrPDB 49 5e-06 5VC6-A nrPDB 49 6e-06 5X1R-A nrPDB 48 7e-06 4RC3-A nrPDB 48 8e-06 3BGP-A nrPDB 48 8e-06 3HMP-A nrPDB 47 1e-05 5AP3-A nrPDB 47 1e-05 2A27-A nrPDB 47 1e-05 1ZWS-A nrPDB 47 2e-05 3N9X-A nrPDB 47 2e-05 2WTK-B nrPDB 46 2e-05 2Y4I-B nrPDB 46 2e-05 5VD3-A nrPDB 46 3e-05 3RP9-A nrPDB 45 4e-05 2ZMD-A nrPDB 45 5e-05 5YKS-A nrPDB 45 5e-05 2VD5-A nrPDB 45 5e-05 4O2Z-A nrPDB 45 6e-05 6O6Q-A nrPDB 44 8e-05 4LQP-A nrPDB 44 9e-05 5Y86-A nrPDB 44 1e-04 3NIE-A nrPDB 44 2e-04 2WO6-A nrPDB 43 2e-04 3PG1-A nrPDB 43 2e-04 2OZA-A nrPDB 43 3e-04 1NY3-A nrPDB 43 3e-04 3KA0-A nrPDB 42 4e-04 5GZA-A nrPDB 41 8e-04 6FYV-A nrPDB 41 0.001 5ZTN-A nrPDB 41 0.001 3EB0-A nrPDB 40 0.001 5X8I-B nrPDB 40 0.002 5CLR-A nrPDB 40 0.002 5M07-A nrPDB 39 0.003 1TKI-A nrPDB 39 0.004 5UNP-A nrPDB 39 0.006 5VDK-A nrPDB 39 0.006 2WTK-C nrPDB 37 0.010 4IAN-A nrPDB 36 0.034 4F9B-A nrPDB 36 0.036 5X18-A nrPDB 35 0.050 4JRN-A nrPDB 35 0.066 4MD7-E nrPDB 34 0.11 6EII-A nrPDB 34 0.12 3LLT-A nrPDB 34 0.12 5GZ9-A nrPDB 34 0.13 2JD5-A nrPDB 33 0.17 4LFI-A nrPDB 33 0.18 5XVU-A nrPDB 31 0.86 5L3X-B nrPDB 31 0.89 2CMW-A nrPDB 31 1.0 6GML-W nrPDB 30 1.8 2X7G-A nrPDB 30 2.0 6HMD-A nrPDB 29 3.5 4XHL-A nrPDB 29 3.8 1V6C-A nrPDB 29 4.2 1CSN-A nrPDB 29 4.6 4XHH-A nrPDB 28 5.3 5G2X-C nrPDB 28 6.1 2PVN-A nrPDB 28 6.1 2V3C-C nrPDB 28 8.2 6ED3-A nrPDB 28 9.1 >5TOS-A nrPDB Length = 395 Score = 818 bits (2112), Expect = 0.0, Method: Compositional matrix adjust. Identities = 395/395 (100%), Positives = 395/395 (100%) Query: 1 MGSCFSSRVKADIFHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNEL 60 MGSCFSSRVKADIFHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNEL Sbjct: 1 MGSCFSSRVKADIFHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNEL 60 Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT Sbjct: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV Sbjct: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM Sbjct: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS Sbjct: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 Query: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPS 360 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPS Sbjct: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPS 360 Query: 361 QTNPVKDTKKLGFKTGTTKSSEKRFTQKPFGRHLV 395 QTNPVKDTKKLGFKTGTTKSSEKRFTQKPFGRHLV Sbjct: 361 QTNPVKDTKKLGFKTGTTKSSEKRFTQKPFGRHLV 395 >6J5U-C nrPDB Length = 426 Score = 430 bits (1105), Expect = e-121, Method: Compositional matrix adjust. Identities = 205/350 (58%), Positives = 273/350 (78%), Gaps = 3/350 (0%) Query: 41 KTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGL 100 +TEGEILSS +K+FTFNELK AT+NFR D+++GEGGFGCVFKGW+D+++LT ++PG+G+ Sbjct: 60 RTEGEILSSPNLKAFTFNELKNATKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGI 119 Query: 101 VIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLEN 160 V+AVK+L EGFQGH+EWLTE+NYLGQLSHPNLV L+GYC E E+RLLVYEFM KGSLEN Sbjct: 120 VVAVKQLKPEGFQGHKEWLTEVNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLEN 179 Query: 161 HLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSD 220 HLFRRGA +PL W +R+ VA+ AAKGL FLH +VIYRD KA+NILLDAD+NAKLSD Sbjct: 180 HLFRRGA--QPLTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSD 237 Query: 221 FGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 FGLA+ GP GD ++VST+V+GT+GYAAPEY+++G L A+SDVYSFGV+LLE++SG+RA+D Sbjct: 238 FGLAKAGPTGDNTHVSTKVIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMD 297 Query: 281 HNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP 340 ++ E +LVDWA PYL KRK+ I+D +L QY + A A++A+QCL+ + K RP Sbjct: 298 NSNGGNEYSLVDWATPYLGDKRKLFRIMDTKLGGQYPQKGAFTAANLALQCLNPDAKLRP 357 Query: 341 TMDQVVRALQQLQDNLGKPSQTNPVKDTKKLGFKTGTTKSSEKRFTQKPF 390 M +V+ L+QL+ ++ KP + ++ + + KS + +P Sbjct: 358 KMSEVLVTLEQLE-SVAKPGTKHTQMESPRFHHSSVMQKSPVRYSHDRPL 406 >3UIM-A nrPDB Length = 326 Score = 215 bits (547), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 123/304 (40%), Positives = 187/304 (61%), Gaps = 18/304 (5%) Query: 52 VKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEG 111 +K F+ EL++A+ NF +++G GGFG V+KG L + TL +AVK+L +E Sbjct: 17 LKRFSLRELQVASDNFSNKNILGRGGFGKVYKGRLADGTL----------VAVKRLKEER 66 Query: 112 FQGHR-EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFK 170 QG ++ TE+ + H NL++L G+C+ RLLVY +M GS+ + L R Sbjct: 67 TQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQP 126 Query: 171 PLPWFLRVNVALDAAKGLAFL--HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGP 228 PL W R +AL +A+GLA+L H DP K+I+RD+KA+NILLD ++ A + DFGLA+ Sbjct: 127 PLDWPKRQRIALGSARGLAYLHDHCDP-KIIHRDVKAANILLDEEFEAVVGDFGLAKLMD 185 Query: 229 MGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEE 288 D ++V+T V GT G+ APEY+S+G + ++DV+ +GV+LLE+++G+RA D R A ++ Sbjct: 186 YKD-THVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAFDLARLANDD 244 Query: 289 N--LVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVV 346 + L+DW + L K K+ +VD L Y EE ++ VA+ C P RP M +VV Sbjct: 245 DVMLLDWVKGLLKEK-KLEALVDVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEVV 303 Query: 347 RALQ 350 R L+ Sbjct: 304 RMLE 307 >5XD6-A nrPDB Length = 305 Score = 210 bits (534), Expect = 9e-55, Method: Compositional matrix adjust. Identities = 129/308 (41%), Positives = 189/308 (61%), Gaps = 20/308 (6%) Query: 52 VKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEG 111 V + +EL+ T N+ S+IGEG +G VF G L +G A+KKL+ Sbjct: 9 VAAIPADELRDITDNYGSKSLIGEGSYGRVFYGILK----------SGKAAAIKKLDSSK 58 Query: 112 FQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR----GA 167 Q +E+L +++ + +L N+V L+GYC++ R+L YE+ GSL + L R GA Sbjct: 59 -QPDQEFLAQVSMVSRLRQENVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGA 117 Query: 168 YFKP-LPWFLRVNVALDAAKGLAFLH--SDPVKVIYRDIKASNILLDADYNAKLSDFGLA 224 P L W RV +A+ AA+GL +LH ++P VI+RDIK+SN+LL D AK++DF L+ Sbjct: 118 QPGPVLSWHQRVKIAVGAARGLEYLHEKANP-HVIHRDIKSSNVLLFDDDVAKIADFDLS 176 Query: 225 RDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRP 284 P STRV+GT+GY APEY +G L+ +SDVYSFGV+LLE+L+G++ +DH P Sbjct: 177 NQAPDMAARLHSTRVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKPVDHTLP 236 Query: 285 AKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQ 344 ++++V WA P L S+ KV VD RL+ +Y P+ ++A+VA C+ +E RP M Sbjct: 237 RGQQSVVTWATPKL-SEDKVKQCVDARLNGEYPPKAVAKLAAVAALCVQYEADFRPNMSI 295 Query: 345 VVRALQQL 352 VV+ALQ L Sbjct: 296 VVKALQPL 303 >5LPZ-A nrPDB Length = 332 Score = 205 bits (522), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 126/328 (38%), Positives = 185/328 (56%), Gaps = 17/328 (5%) Query: 51 PVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE 110 P++ F +L AT F DS+IG GGFG V+K L + G +A+KKL Sbjct: 3 PLRKLAFADLLQATNGFHNDSLIGSGGFGDVYKAILKD----------GSAVAIKKLIHV 52 Query: 111 GFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFK 170 QG RE++ E+ +G++ H NLV L+GYC + RLLVYEFM+ GSLE+ L Sbjct: 53 SGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGV 112 Query: 171 PLPWFLRVNVALDAAKGLAFLHSD-PVKVIYRDIKASNILLDADYNAKLSDFGLARDGPM 229 L W R +A+ +A+GLAFLH + +I+RD+K+SN+LLD + A++SDFG+AR Sbjct: 113 KLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSA 172 Query: 230 GDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEEN 289 D + + GT GY PEY S + + DVYS+GV+LLE+L+GKR D + + N Sbjct: 173 MDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTD-SPDFGDNN 231 Query: 290 LVDWARPYLTSKRKVLLIVDNRL--DTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 LV W + + +K ++ + D L + L E ++ VAV CL RPTM QV+ Sbjct: 232 LVGWVKQH--AKLRISDVFDPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVMA 289 Query: 348 ALQQLQDNLGKPSQTNPVKDTKKLGFKT 375 +++Q G SQ+ ++ + GF T Sbjct: 290 MFKEIQAGSGIDSQST-IRSIEDGGFST 316 >6CTH-A nrPDB Length = 309 Score = 200 bits (508), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 122/306 (39%), Positives = 179/306 (58%), Gaps = 26/306 (8%) Query: 52 VKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEG 111 ++ F+ NEL T NF ++ +GEGGFG V++G+L +S IAVKK+++ Sbjct: 2 MRKFSLNELAKVTSNFNAENKLGEGGFGSVYRGFLRDSDT---------YIAVKKVSRAS 52 Query: 112 FQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKP 171 QG +E+ +E+ + +L H NLVKLIG+C E +LVYEFM GSL++H+F+ + Sbjct: 53 KQGIKEYASEVKIISRLRHKNLVKLIGWCHERGELMLVYEFMANGSLDSHIFKGKSL--- 109 Query: 172 LPWFLRVNVALDAAKGLAFLHSDPVK-VIYRDIKASNILLDADYNAKLSDFGLAR--DGP 228 L W +R + D A L +LH + V++RDIK SNI+LD+ +NAKL DFGLAR D Sbjct: 110 LTWEVRYRIVKDLASALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHA 169 Query: 229 MGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEE 288 G T + GT GY APE +SSG + SDVYSFGV+ LEI SG+R+++ P EE Sbjct: 170 KG---LKKTLLAGTVGYMAPECLSSGKASKESDVYSFGVVALEIASGRRSIE---PKFEE 223 Query: 289 N----LVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQ 344 + LV W ++R +L I D +L + P++ + V + C RP++ Q Sbjct: 224 SEALLLVPWVWESYGNER-ILDIADRKLGMAFDPKQLECLVMVGLWCAHPSHNLRPSIRQ 282 Query: 345 VVRALQ 350 V++ L Sbjct: 283 VIQVLN 288 >5LPV-A nrPDB Length = 296 Score = 199 bits (507), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 120/306 (39%), Positives = 175/306 (57%), Gaps = 16/306 (5%) Query: 51 PVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE 110 P++ F +L AT F DS+IG GGFG V+K L + G +A+KKL Sbjct: 3 PLRKLAFADLLQATNGFHNDSLIGSGGFGDVYKAILKD----------GSAVAIKKLIHV 52 Query: 111 GFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFK 170 QG RE++ E+ +G++ H NLV L+GYC + RLLVYEFM+ GSLE+ L Sbjct: 53 SGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGV 112 Query: 171 PLPWFLRVNVALDAAKGLAFLHSD-PVKVIYRDIKASNILLDADYNAKLSDFGLARDGPM 229 L W R +A+ +A+GLAFLH + +I+RD+K+SN+LLD + A++SDFG+AR Sbjct: 113 KLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSA 172 Query: 230 GDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEEN 289 D + + GT GY PEY S + + DVYS+GV+LLE+L+GKR D + + N Sbjct: 173 MDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTD-SPDFGDNN 231 Query: 290 LVDWARPYLTSKRKVLLIVDNRL--DTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 LV W + + +K ++ + D L + L E ++ VAV CL RPTM QV+ Sbjct: 232 LVGWVKQH--AKLRISDVFDPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVMA 289 Query: 348 ALQQLQ 353 +++Q Sbjct: 290 MFKEIQ 295 >2QKW-B nrPDB Length = 321 Score = 184 bits (466), Expect = 8e-47, Method: Compositional matrix adjust. Identities = 115/322 (35%), Positives = 180/322 (55%), Gaps = 18/322 (5%) Query: 34 STVAAAQKTEGEILSST---PVKSFT--FNELKLATRNFRPDSVIGEGGFGCVFKGWLDE 88 S + A + + LSS+ P +S+ +L+ AT NF +IG G FG V+KG L + Sbjct: 3 SKYSKATNSINDALSSSYLVPFESYRVPLVDLEEATNNFDHKFLIGHGVFGKVYKGVLRD 62 Query: 89 STLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLL 148 G +A+K+ E QG E+ TEI L HP+LV LIG+C E +L Sbjct: 63 ----------GAKVALKRRTPESSQGIEEFETEIETLSFCRHPHLVSLIGFCDERNEMIL 112 Query: 149 VYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNI 208 +Y++M+ G+L+ HL+ + W R+ + + AA+GL +LH+ + I+RD+K+ NI Sbjct: 113 IYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAI--IHRDVKSINI 170 Query: 209 LLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVL 268 LLD ++ K++DFG+++ G D +++ST V GT GY PEY G L +SDVYSFGV+ Sbjct: 171 LLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRLTEKSDVYSFGVV 230 Query: 269 LLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVA 328 L E+L + A+ + P + NL +WA + ++ IVD L + PE + A Sbjct: 231 LFEVLCARSAIVQSLPREMVNLAEWAVES-HNNGQLEQIVDPNLADKIRPESLRKFGDTA 289 Query: 329 VQCLSFEPKSRPTMDQVVRALQ 350 V+CL+ + RP+M V+ L+ Sbjct: 290 VKCLALSSEDRPSMGDVLWKLE 311 >5UIU-A nrPDB Length = 323 Score = 176 bits (445), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 117/313 (37%), Positives = 178/313 (56%), Gaps = 22/313 (7%) Query: 47 LSSTPVKSFTFNELKLATRNF--RPDSV----IGEGGFGCVFKGWLDESTLTPTKPGTGL 100 +S T SF+F ELK T NF RP SV +GEGGFG V+KG+++ +T+ K + Sbjct: 23 VSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMV 82 Query: 101 VIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLEN 160 I ++L Q+ Q EI + + H NLV+L+G+ + + LVY +M GSL + Sbjct: 83 DITTEELKQQFDQ-------EIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLD 135 Query: 161 HLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSD 220 L PL W +R +A AA G+ FLH + I+RDIK++NILLD + AK+SD Sbjct: 136 RLSCLDGT-PPLSWHMRCKIAQGAANGINFLHEN--HHIHRDIKSANILLDEAFTAKISD 192 Query: 221 FGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 FGLAR + +++R++GT Y APE + G + +SD+YSFGV+LLEI++G A+D Sbjct: 193 FGLARASEKFAQTVMTSRIVGTTAYMAPEAL-RGEITPKSDIYSFGVVLLEIITGLPAVD 251 Query: 281 HNRPAKEENLVDWARPYLTSKRKVLLIVDNRL-DTQYLPEEAVRMASVAVQCLSFEPKSR 339 +R + + L+D ++ + +D ++ D EA M SVA QCL + R Sbjct: 252 EHR--EPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEA--MYSVASQCLHEKKNKR 307 Query: 340 PTMDQVVRALQQL 352 P + +V + LQ++ Sbjct: 308 PDIKKVQQLLQEM 320 >6BFN-A nrPDB Length = 342 Score = 155 bits (392), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 111/336 (33%), Positives = 158/336 (47%), Gaps = 48/336 (14%) Query: 54 SFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ---- 109 + E+ T NF + IGEGGFGCV++ + + V AVK+L + Sbjct: 11 CWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNT-----------VYAVKRLKENADL 59 Query: 110 EGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF 169 E + +LTE+ L + HPN+V GYC ++ LVY F+ GSLE+ L + Sbjct: 60 EWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQAC 119 Query: 170 KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR---- 225 PL W R+++ L A+ + FLH D +I+ DIK+SN+LLD KL DFGLAR Sbjct: 120 PPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRF 179 Query: 226 DGPMGDLSYVSTR---VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHN 282 G S + R V GT Y EY+ +G L +D +SFGV++LE L+G+RA+ Sbjct: 180 AGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVK-T 238 Query: 283 RPAKEENLVDWARPY-------LTSKRKVL---------------LIVDNRLDTQ---YL 317 A+ + L D L S + L I LD + Sbjct: 239 HGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCP 298 Query: 318 PEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQ 353 PE + + +A CL K RP M QV L++LQ Sbjct: 299 PELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQ 334 >4I94-A nrPDB Length = 300 Score = 154 bits (390), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 98/312 (31%), Positives = 162/312 (51%), Gaps = 34/312 (10%) Query: 48 SSTPVKSFTFNELKLATRNFRPDSVIGEGGF---GCVFKGWLDESTLTPTKPGTGLVIAV 104 SS + F+ ++ AT F ++++ E G V+KG L+ IAV Sbjct: 9 SSGQFREFSIETIRNATSGFAAENIVSEHGERAPNVVYKGKLENQR----------RIAV 58 Query: 105 KKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFR 164 K+ N++ + R++L E +GQL + + L+G C EDE RLL+ EFM +L HLF Sbjct: 59 KRFNRKSWPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEERLLIAEFMPNETLAKHLFH 118 Query: 165 RGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLA 224 + +P+ W +R+ VAL A+ L + S + +Y D+ A +L D D N +LS FGL Sbjct: 119 WES--QPMKWAMRLRVALHIAQALEYCTSKG-RALYHDLNAYRVLFDDDANPRLSCFGLM 175 Query: 225 RDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRP 284 ++ G SY + + PEY+ +G + S +YSFG LLL++LSGK H P Sbjct: 176 KNSRDGK-SYST-----NLAFTPPEYLRTGRVTPESVIYSFGTLLLDLLSGK----HIPP 225 Query: 285 AKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQ 344 + +L+ R + +++D+ L+ Q+ ++ + +A +CL +EP+ RP Sbjct: 226 SHALDLI--------RDRNIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRERPNPKS 277 Query: 345 VVRALQQLQDNL 356 +V A+ LQ +L Sbjct: 278 LVSAMIPLQKDL 289 >4L68-A nrPDB Length = 340 Score = 145 bits (365), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 101/315 (32%), Positives = 165/315 (52%), Gaps = 22/315 (6%) Query: 47 LSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKK 106 L P+ +L AT NF +++I G +K L + G +AVK Sbjct: 22 LFQKPLVKVKLGDLMAATNNFNSENIIVSTRTGTTYKALLPD----------GSALAVKH 71 Query: 107 LNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHL-FRR 165 L+ G RE+ E+N L +L H NL L+G+C+ +E + LVY++M G+L + L R Sbjct: 72 LSTCKL-GEREFRYEMNQLWELRHSNLAPLLGFCVVEEEKFLVYKYMSNGTLHSLLDSNR 130 Query: 166 GAYFKPLPWFLRVNVALDAAKGLAFLHSDPV-KVIYRDIKASNILLDADYNAKLSDFGLA 224 G L W R + L AA+GLA+LH +++++I +S IL+D D++A++ D GLA Sbjct: 131 G----ELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLA 186 Query: 225 RDGPMGDLSYVS--TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHN 282 R D + S T +G +GY APEY ++ + + DVY GV+LLE+ +G +A+ Sbjct: 187 RLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLKGDVYGLGVVLLELATGLKAV--G 244 Query: 283 RPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTM 342 + +LVDW + L S ++ D + + EE + +A+ C+S PK R +M Sbjct: 245 GEGFKGSLVDWVKQ-LESSGRIAETFDENIRGKGHDEEISKFVEIALNCVSSRPKERWSM 303 Query: 343 DQVVRALQQLQDNLG 357 Q ++L+ + + G Sbjct: 304 FQAYQSLKAIAEKQG 318 >6J6I-B nrPDB Length = 351 Score = 127 bits (319), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 90/328 (27%), Positives = 160/328 (48%), Gaps = 34/328 (10%) Query: 49 STPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN 108 S P++SF+ ++ AT NF + + + ++G +++ + +K+ + Sbjct: 42 SIPIRSFSPEQILKATNNFDSSCFVSQDVYYKWYRGEIEDRSYM-----------IKRFS 90 Query: 109 QEGFQGHREWLTEINYLGQLS-----HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLF 163 ++ G R + E+ LS H N ++L+G CLE +LV+EF + G++ Sbjct: 91 EDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPVLVFEFAEHGAMN---- 146 Query: 164 RRGAYF-----KPLPWFLRVNVALDAAKGLAFLHSD-PVKVIYRDIKASNILLDADYNAK 217 +RG LPW +R+ + + A + +LH+ P +I+RD+K ++ LD ++ AK Sbjct: 147 QRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAK 206 Query: 218 LSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKR 277 LSD + P G + V+GT+GY P Y + + +DVYSFG+ LL I++GK Sbjct: 207 LSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYSFGICLLVIITGKP 266 Query: 278 ALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRL-----DTQYLPEEAVRMASVAVQCL 332 A+ + ++ R L K+ ++D RL Q L EA +A++C Sbjct: 267 AIMTISDGDLQGILSLVRE-LCENGKLDEVIDPRLMKDITSGQRLQVEAC--VVLALRCC 323 Query: 333 SFEPKSRPTMDQVVRALQQLQDNLGKPS 360 + RP M QV + L+Q++ +L S Sbjct: 324 KERDEDRPKMIQVAKELKQIEASLKNSS 351 >3PPZ-A nrPDB Length = 309 Score = 115 bits (287), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 86/284 (30%), Positives = 145/284 (51%), Gaps = 36/284 (12%) Query: 73 IGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR--EWLTEINYLGQLS 129 IG G FG V + W G +AVK L ++ F R E+L E+ + +L Sbjct: 45 IGAGSFGTVHRAEW------------HGSDVAVKILMEQDFHAERVNEFLREVAIMKRLR 92 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 HPN+V +G + + +V E++ +GSL L + GA + L R+++A D AKG+ Sbjct: 93 HPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQ-LDERRRLSMAYDVAKGMN 151 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR-VMGTYGYAAP 248 +LH+ +++RD+K+ N+L+D Y K+ DFGL+R + +++S++ GT + AP Sbjct: 152 YLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSR---LKASTFLSSKSAAGTPEWMAP 208 Query: 249 EYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIV 308 E + N +SDVYSFGV+L E+ + ++ + PA+ V KR L + Sbjct: 209 EVLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVG-----FKCKR---LEI 260 Query: 309 DNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 L+ Q +A++ C + EP RP+ ++ L+ L Sbjct: 261 PRNLNPQ--------VAAIIEGCWTNEPWKRPSFATIMDLLRPL 296 >5HLW-A nrPDB Length = 299 Score = 107 bits (267), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 91/289 (31%), Positives = 139/289 (48%), Gaps = 35/289 (12%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-REWLTEINYLGQL 128 + VIG G FGCV+ G L ++ G + AVK LN+ G ++LTE + Sbjct: 25 NEVIGRGHFGCVYHGTLLDND------GKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDF 78 Query: 129 SHPNLVKLIGYCLEDEHR-LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 SHPN++ L+G CL E L+V +M+ G L N F R P L + L AKG Sbjct: 79 SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRN--FIRNETHNPTVKDL-IGFGLQVAKG 135 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS----TRVMGTY 243 + +L S K ++RD+ A N +LD + K++DFGLARD M D Y S T Sbjct: 136 MKYLASK--KFVHRDLAARNCMLDEKFTVKVADFGLARD--MHDKEYYSVHNKTGAKLPV 191 Query: 244 GYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRK 303 + A E + + +SDV+SFGVLL E+++ P + N D YL R+ Sbjct: 192 KWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAP-----PYPDVNTFD-ITVYLLQGRR 245 Query: 304 VLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 + L +Y P+ + V ++C + + RP+ ++V + + Sbjct: 246 L-------LQPEYCPDP---LYEVMLKCWHPKAEMRPSFSELVSRISAI 284 >4GS6-A nrPDB Length = 315 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 81/290 (27%), Positives = 141/290 (48%), Gaps = 48/290 (16%) Query: 70 DSVIGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQL 128 + V+G G FG V K W + +A+K++ E + + ++ E+ L ++ Sbjct: 14 EEVVGRGAFGVVCKAKWRAKD------------VAIKQIESESER--KAFIVELRQLSRV 59 Query: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV---ALDAA 185 +HPN+VKL G CL LV E+ + GSL N L GA +PLP++ + L + Sbjct: 60 NHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVL--HGA--EPLPYYTAAHAMSWCLQCS 113 Query: 186 KGLAFLHS-DPVKVIYRDIKASNILLDADYNA-KLSDFGLARDGPMGDLSYVSTRVMGTY 243 +G+A+LHS P +I+RD+K N+LL A K+ DFG A D+ T G+ Sbjct: 114 QGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTA-----CDIQTHMTNNKGSA 168 Query: 244 GYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDH-NRPAKEENLVDWARPYLTSKR 302 + APE + + + DV+S+G++L E+++ ++ D PA Sbjct: 169 AWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPA----------------F 212 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 +++ V N + + S+ +C S +P RP+M+++V+ + L Sbjct: 213 RIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHL 262 >3C1X-A nrPDB Length = 373 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 88/287 (30%), Positives = 137/287 (47%), Gaps = 31/287 (10%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-REWLTEINYLGQL 128 + VIG G FGCV+ G L ++ G + AVK LN+ G ++LTE + Sbjct: 94 NEVIGRGHFGCVYHGTLLDND------GKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDF 147 Query: 129 SHPNLVKLIGYCLEDEHR-LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 SHPN++ L+G CL E L+V +M+ G L N F R P L + L AKG Sbjct: 148 SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRN--FIRNETHNPTVKDL-IGFGLQVAKG 204 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT--YGY 245 + FL S K ++RD+ A N +LD + K++DFGLARD + V + + Sbjct: 205 MKFLASK--KFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKW 262 Query: 246 AAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVL 305 A E + + +SDV+SFGVLL E+++ P + N D YL R++ Sbjct: 263 MALESLQTQKFTTKSDVWSFGVLLWELMTRGAP-----PYPDVNTFDITV-YLLQGRRL- 315 Query: 306 LIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 L +Y P+ + V ++C + + RP+ ++V + + Sbjct: 316 ------LQPEYCPDP---LYEVMLKCWHPKAEMRPSFSELVSRISAI 353 >3QGY-A nrPDB Length = 286 Score = 105 bits (261), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 83/286 (29%), Positives = 137/286 (47%), Gaps = 39/286 (13%) Query: 73 IGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 IG G FG V G WL++ +A+K + +EG +++ E + +LSHP Sbjct: 35 IGSGQFGLVHLGYWLNKDK-----------VAIKTI-KEGSMSEDDFIEEAEVMMKLSHP 82 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 LV+L G CLE LV+EFM+ G L ++L + F + + LD +G+A+L Sbjct: 83 KLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAET---LLGMCLDVCEGMAYL 139 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM 251 + VI+RD+ A N L+ + K+SDFG+ R + D ST +A+PE Sbjct: 140 --EEACVIHRDLAARNCLVGENQVIKVSDFGMTR-FVLDDQYTSSTGTKFPVKWASPEVF 196 Query: 252 SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE--ENLVDWARPYLTSKRKVLLIVD 309 S +++SDV+SFGVL+ E+ S + NR E E++ R Y Sbjct: 197 SFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLY-----------K 245 Query: 310 NRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 RL + ++ + + C P+ RP +++R L ++ ++ Sbjct: 246 PRLASTHVYQ-------IMNHCWKERPEDRPAFSRLLRQLAEIAES 284 >5HVK-A nrPDB Length = 315 Score = 103 bits (258), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 88/326 (26%), Positives = 147/326 (45%), Gaps = 46/326 (14%) Query: 65 RNFRPD-----SVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL 119 R FRP V+G+G FG + T TG V+ +K+L + + R +L Sbjct: 9 RIFRPSDLIHGEVLGKGCFG---------QAIKVTHRETGEVMVMKELIRFDEETQRTFL 59 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 E+ + L HPN++K IG +D+ + E+++ G+L + + + PW RV+ Sbjct: 60 KEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQY---PWSQRVS 116 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR------DGPMGDLS 233 A D A G+A+LHS + +I+R++ + N L+ + N ++DFGLAR P G S Sbjct: 117 FAKDIASGMAYLHS--MNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRS 174 Query: 234 YVST------RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE 287 V+G + APE ++ + + DV+SFG++L EI+ G+ D + Sbjct: 175 LKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEII-GRVNADPD----- 228 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 YL L V LD P + V+C +P+ RP+ ++ Sbjct: 229 ---------YLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEH 279 Query: 348 ALQQLQDNLGKPSQTNPVKDTKKLGF 373 L+ L+ +L P + GF Sbjct: 280 WLETLRMHLAGHLPLGPQLEQLDRGF 305 >4UYA-A nrPDB Length = 340 Score = 103 bits (258), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 75/238 (31%), Positives = 118/238 (49%), Gaps = 39/238 (16%) Query: 55 FTFNELKLATRNFRPDSVIGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQEGFQ 113 F + + +A +IG GGFG V++ W G +AVK Q+ Q Sbjct: 16 FQGSPVHVAFERLELKELIGAGGFGQVYRATW------------QGQEVAVKAARQDPEQ 63 Query: 114 ----GHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF 169 E L HPN+++L G CL+ H LV EF + G+L L R Sbjct: 64 DAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAGRR--- 120 Query: 170 KPLPWFLRVNVALDAAKGLAFLHSDP-VKVIYRDIKASNILL--------DADYNAKLSD 220 +P + VN A+ A+G+ +LH + V +++RD+K+SNILL + K++D Sbjct: 121 --IPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITD 178 Query: 221 FGLARDGPMGDLSYVSTRV--MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 FGLAR+ + +T++ G Y + APE + S + SD++S+GVLL E+L+G+ Sbjct: 179 FGLAREW------HRTTKMATAGAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGE 230 >4UY9-A nrPDB Length = 323 Score = 103 bits (257), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 85/304 (27%), Positives = 148/304 (48%), Gaps = 59/304 (19%) Query: 70 DSVIGEGGFGCVFKG-WL-DESTLTPTK--PGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 + +IG GGFG V++ W+ DE + + P + ++ + QE Sbjct: 14 EEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEA-----------KLF 62 Query: 126 GQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 L HPN++ L G CL++ + LV EF + G L R K +P + VN A+ A Sbjct: 63 AMLKHPNIIALRGVCLKEPNLCLVMEFARGGPL-----NRVLSGKRIPPDILVNWAVQIA 117 Query: 186 KGLAFLHSDP-VKVIYRDIKASNILL-----DADYN---AKLSDFGLARDGPMGDLSYVS 236 +G+ +LH + V +I+RD+K+SNIL+ + D + K++DFGLAR+ + + Sbjct: 118 RGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREW------HRT 171 Query: 237 TRV--MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK---RALDHNRPAKEENLV 291 T++ GTY + APE + + + SDV+S+GVLL E+L+G+ R +D Sbjct: 172 TKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGID----------- 220 Query: 292 DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 A Y + K+ L + + + A + C + +P SRP+ ++ L Sbjct: 221 GLAVAYGVAMNKLALPIPSTCPEPF--------AKLMEDCWNPDPHSRPSFTNILDQLTT 272 Query: 352 LQDN 355 ++++ Sbjct: 273 IEES 276 >4F0G-A nrPDB Length = 287 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 80/301 (26%), Positives = 143/301 (47%), Gaps = 39/301 (12%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWL--DESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL 119 LA + IG+GGFG V KG L D+S + L++ + E + +E+ Sbjct: 16 LADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIK----SLILGDSEGETEMIEKFQEFQ 71 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 E+ + L+HPN+VKL Y L +V EF+ G L + L + P+ W +++ Sbjct: 72 REVFIMSNLNHPNIVKL--YGLMHNPPRMVMEFVPCGDLYHRLLDKA---HPIKWSVKLR 126 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILL-----DADYNAKLSDFGLARDGPMGDLSY 234 + LD A G+ ++ + +++RD+++ NI L +A AK++DFGL++ + Sbjct: 127 LMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQS-----VH 181 Query: 235 VSTRVMGTYGYAAPEYMSSGH--LNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVD 292 + ++G + + APE + + ++D YSF ++L IL+G+ D Sbjct: 182 SVSGLLGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDE----------- 230 Query: 293 WARPYLTSKRKVLLIVDNRLDTQYLPEEA-VRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 Y K K + ++ +PE+ R+ +V C S +PK RP +V+ L + Sbjct: 231 ----YSYGKIKFINMIREEGLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVKELSE 286 Query: 352 L 352 L Sbjct: 287 L 287 >5WNL-A nrPDB Length = 342 Score = 100 bits (250), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 85/320 (26%), Positives = 139/320 (43%), Gaps = 35/320 (10%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +G GGFG V+K + T L I + E L E + Sbjct: 28 VGSGGFGQVYK-------VRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRY 80 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 ++ + G C E LV E+M+ GSLE L +PLPW LR + + A G+ FLH Sbjct: 81 ILPVYGICQEPVG--LVMEYMETGSLEKLLAS-----EPLPWDLRFRIVHETAVGMNFLH 133 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR-VMGTYGYAAPEYM 251 +++ ++K +NILLDA Y+ K+SDFGLA+ M +S + GT Y PE + Sbjct: 134 CMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERI 193 Query: 252 --SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVD 309 S + + DVYSF +++ +L+ K+ A E+N++ + R L + Sbjct: 194 REKSRLFDTKHDVYSFAIVIWGVLTQKKPF-----ADEKNILHIMMKVVKGHRPELPPI- 247 Query: 310 NRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVKDTK 369 + P + + +C +P+ RPT ++ + L + P ++ K Sbjct: 248 ----CRPRPRACASLIGLMQRCWHADPQVRPTFQEITSETEDLCE--------KPDEEVK 295 Query: 370 KLGFKTGTTKSSEKRFTQKP 389 L + G S E + +P Sbjct: 296 DLAHEPGEKSSLESKSEARP 315 >6DBM-A nrPDB Length = 318 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 96/291 (32%), Positives = 133/291 (45%), Gaps = 26/291 (8%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYLGQLSHP 131 +GEG FG V D PT GTG ++AVK L + HR W EI+ L L H Sbjct: 39 LGEGHFGKVSLYCYD-----PTNDGTGEMVAVKALKADAGPQHRSGWKQEIDILRTLYHE 93 Query: 132 NLVKLIGYCLEDEHRL---LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 +++K G C ED LV E++ GSL ++L R L F A +G+ Sbjct: 94 HIIKYKG-CCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGLAQLLLF-----AQQICEGM 147 Query: 189 AFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG--TYGYA 246 A+LHS I+RD+ A N+LLD D K+ DFGLA+ P G Y R G + Sbjct: 148 AYLHSQ--HYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGH-EYYRVREDGDSPVFWY 204 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKV-L 305 APE + SDV+SFGV L E+L+ + + P K L+ A+ +T R L Sbjct: 205 APECLKEYKFYYASDVWSFGVTLYELLTHCDS-SQSPPTKFLELIGIAQGQMTVLRLTEL 263 Query: 306 LIVDNRLD-TQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 L RL P E + C E RPT + ++ L+ + + Sbjct: 264 LERGERLPRPDKCPAEVYHLMK---NCWETEASFRPTFENLIPILKTVHEK 311 >4OLI-A nrPDB Length = 645 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 92/289 (31%), Positives = 136/289 (47%), Gaps = 24/289 (8%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYLGQLSHP 131 +GEG FG V D PT GTG ++AVK L + HR W EI+ L L H Sbjct: 361 LGEGHFGKVSLYCYD-----PTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHE 415 Query: 132 NLVKLIGYCLEDEHR---LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 +++K G C ED+ LV E++ GSL ++L R L F A +G+ Sbjct: 416 HIIKYKG-CCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLF-----AQQICEGM 469 Query: 189 AFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYG--YA 246 A+LHS I+R++ A N+LLD D K+ DFGLA+ P G Y R G + Sbjct: 470 AYLHSQ--HYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGH-EYYRVREDGDSPVFWY 526 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLL 306 APE + SDV+SFGV L E+L+ + + P K L+ A+ +T R L Sbjct: 527 APECLKEYKFYYASDVWSFGVTLYELLTHCDS-SQSPPTKFLELIGIAQGQMTVLRLTEL 585 Query: 307 IVDNRLDTQYLPEEA-VRMASVAVQCLSFEPKSRPTMDQVVRALQQLQD 354 + R + P++ + + C E RPT + ++ L+ + + Sbjct: 586 L--ERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHE 632 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 76/291 (26%), Positives = 128/291 (43%), Gaps = 44/291 (15%) Query: 87 DESTLTPTKP-GTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEH 145 DE L P + G L + +K L+ + + + Q+SH +L + G C+ Sbjct: 81 DEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPE 140 Query: 146 RLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKA 205 ++V E+++ G L+ L R + P+ W ++ VA A L++L + +++ ++ Sbjct: 141 NIMVTEYVEHGPLDVWLRRERGHV-PMAW--KMVVAQQLASALSYLENK--NLVHGNVCG 195 Query: 206 SNILL-------DADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSG--HL 256 NILL KLSD G+ +G LS + + APE + G L Sbjct: 196 RNILLARLGLAEGTSPFIKLSDPGVG----LGALS--REERVERIPWLAPECLPGGANSL 249 Query: 257 NARSDVYSFGVLLLEI-LSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQ 315 + D + FG LLEI G+ L P+++E+ Y R Sbjct: 250 STAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHF------YQRQHR------------- 290 Query: 316 YLPEEAV-RMASVAVQCLSFEPKSRPTMDQVVRALQQLQ-DNLGKPSQTNP 364 LPE + ++A++ QCL++EP RP+ ++R L +LQ NL NP Sbjct: 291 -LPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNP 340 >4P5Q-A nrPDB Length = 361 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 81/301 (26%), Positives = 141/301 (46%), Gaps = 33/301 (10%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 +L N D V+G G FG V G L P+K + I K+ Q R++L Sbjct: 29 ELDATNISIDKVVGAGEFGEVCSGRLK----LPSKKEISVAIKTLKVGYTEKQ-RRDFLG 83 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 E + +GQ HPN+++L G + + ++V E+M+ GSL++ L + A F + V + Sbjct: 84 EASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQ---LVGM 140 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR---DGPMGDLSYVST 237 A G+ +L + ++RD+ A NIL++++ K+SDFGL+R D P + +Y + Sbjct: 141 LRGIASGMKYLSD--MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDP--EAAYTTR 196 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY 297 + +PE ++ + SDV+S+G++L E++S RPY Sbjct: 197 GGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGE-----------------RPY 239 Query: 298 L-TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNL 356 S + V+ VD + + + + C + +RP +Q+V L +L N Sbjct: 240 WEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNP 299 Query: 357 G 357 G Sbjct: 300 G 300 >3SXS-A nrPDB Length = 268 Score = 99.4 bits (246), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 86/293 (29%), Positives = 140/293 (47%), Gaps = 53/293 (18%) Query: 73 IGEGGFGCV----FKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQL 128 +G G FG V +KG D +AVK + +EG E+ E + +L Sbjct: 16 LGSGQFGVVKLGKWKGQYD--------------VAVKMI-KEGSMSEDEFFQEAQTMMKL 60 Query: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 SHP LVK G C ++ +V E++ G L N+L G +P + + D +G+ Sbjct: 61 SHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQ---LLEMCYDVCEGM 117 Query: 189 AFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT---YGY 245 AFL S + I+RD+ A N L+D D K+SDFG+ R + D YVS+ +GT + Sbjct: 118 AFLESH--QFIHRDLAARNCLVDRDLCVKVSDFGMTR--YVLDDQYVSS--VGTKFPVKW 171 Query: 246 AAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLTSKRKV 304 +APE +++SDV++FG+L+ E+ S GK D L + +V Sbjct: 172 SAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKMPYD-----------------LYTNSEV 214 Query: 305 LLIVD--NRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 +L V +RL +L + + + C P+ RPT Q++ +++ L++ Sbjct: 215 VLKVSQGHRLYRPHLASDTI--YQIMYSCWHELPEKRPTFQQLLSSIEPLREK 265 >3DTC-A nrPDB Length = 271 Score = 99.0 bits (245), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 84/301 (27%), Positives = 144/301 (47%), Gaps = 59/301 (19%) Query: 70 DSVIGEGGFGCVFKG-WL-DESTLTPTK--PGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 + +IG GGFG V++ W+ DE + + P + ++ + QE Sbjct: 12 EEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEA-----------KLF 60 Query: 126 GQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 L HPN++ L G CL++ + LV EF + G L R K +P + VN A+ A Sbjct: 61 AMLKHPNIIALRGVCLKEPNLCLVMEFARGGPL-----NRVLSGKRIPPDILVNWAVQIA 115 Query: 186 KGLAFLHSDP-VKVIYRDIKASNILL-----DADYN---AKLSDFGLARDGPMGDLSYVS 236 +G+ +LH + V +I+RD+K+SNIL+ + D + K++DFGLAR+ + + Sbjct: 116 RGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREW------HRT 169 Query: 237 TRV--MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK---RALDHNRPAKEENLV 291 T++ G Y + APE + + + SDV+S+GVLL E+L+G+ R +D Sbjct: 170 TKMSAAGAYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGID----------- 218 Query: 292 DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 A Y + K+ L + + + A + C + +P SRP+ ++ L Sbjct: 219 GLAVAYGVAMNKLALPIPSTCPEPF--------AKLMEDCWNPDPHSRPSFTNILDQLTT 270 Query: 352 L 352 + Sbjct: 271 I 271 >5UV4-A nrPDB Length = 311 Score = 98.6 bits (244), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 96/313 (30%), Positives = 155/313 (49%), Gaps = 38/313 (12%) Query: 55 FTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF-Q 113 FT EL A P +IG G +K LD G ++ VK L +EGF + Sbjct: 20 FTAEELSCA-----PAEIIGRSCHGTSYKATLD----------NGYMLTVKWL-KEGFAK 63 Query: 114 GHREWLTEINYLGQLSHPNLVKLIGYCL--EDEHRLLVYEFMQKGSLENHLFRRGAY-FK 170 +E+ EI LG + HPNLV L GY ++ R+++ ++ SL +L Sbjct: 64 SKKEFSREIKKLGSVRHPNLVPLRGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLP 123 Query: 171 PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILL-DADYNAKLSDFGLAR-DGP 228 PL R+N+A+D A+ L +LH++ V + + +IK+SN+L+ ++ +A ++D+ L R P Sbjct: 124 PLSAGQRLNIAIDIARCLDYLHNERV-IPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTP 182 Query: 229 MGDLSYVSTRVMGTYGYAAPEYMSSGH--LNARSDVYSFGVLLLEILSGKRA---LDHNR 283 +G V G GY+ PE+ S+ + +SDVY+FGV+LLE+L+GK A + N Sbjct: 183 IGMAEQVLN--AGALGYSPPEFSSTSKPCPSLKSDVYAFGVILLELLTGKIAGEIICMND 240 Query: 284 PAKEENLVDWARPYLTSKRKVLLIVDNRL----DTQYLPEEAVRMASVAVQCLSFEPKSR 339 +L DW R L + +V D + ++ P+ M +A++C+ R Sbjct: 241 GVV--DLTDWVR-MLDLEERVSECYDRHITGVESSEGAPQALDGMLRIALRCIR-SASER 296 Query: 340 PTMDQVVRALQQL 352 P + V L L Sbjct: 297 PEVRTVFEDLLSL 309 >4TPT-A nrPDB Length = 303 Score = 97.8 bits (242), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 79/306 (25%), Positives = 137/306 (44%), Gaps = 48/306 (15%) Query: 71 SVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSH 130 V+G+G FG + T TG V+ +K+L + + + +LTE+ + L H Sbjct: 6 EVLGKGFFG---------QAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDH 56 Query: 131 PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAF 190 PN++K IG +D+ L+ E+++ G+L++ L P PW +V A A G+A+ Sbjct: 57 PNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFL----RSMDPFPWQQKVRFAKGIASGMAY 112 Query: 191 LHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR----DGPMGDLSYVSTR-------- 238 LHS + +I+RD+ + N L+ D ++DFGL+R + + +T+ Sbjct: 113 LHS--MCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKND 170 Query: 239 ------VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVD 292 V+G + APE ++ + D++SFG++L EI+ A P Sbjct: 171 RKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRT------ 224 Query: 293 WARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 L V L + + T P +A C EP+SRP ++ + + L Sbjct: 225 -----LDFGLNVKLFWEKFVPTDCPPA----FFPLAAICCRLEPESRPAFSKLEDSFEAL 275 Query: 353 QDNLGK 358 LG+ Sbjct: 276 SLYLGE 281 >6EAS-A nrPDB Length = 308 Score = 97.1 bits (240), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 81/309 (26%), Positives = 143/309 (46%), Gaps = 38/309 (12%) Query: 50 TPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ 109 T V S +EL+ A +F ++IG ++KG L S+ + LV + K ++ Sbjct: 27 TGVPSLKRSELETACEDF--SNIIGSTSTCMLYKGTL--SSGVEIAVASSLVTSAKDWSK 82 Query: 110 EGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEH---RLLVYEFMQKGSLENHLFRRG 166 E +R+ +I L ++SH N + L+GYC E+EH R++V+E+ G+L HL R Sbjct: 83 ENESQYRK---KITNLSKVSHKNFMNLLGYC-EEEHPFTRVMVFEYAPNGTLFEHLHVRE 138 Query: 167 AYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD 226 A + L W R+ +++ A L +H R+ ++ + L D+ AK+SD D Sbjct: 139 A--EKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDLEFWND 196 Query: 227 GPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK 286 G E S + V +G++LLEIL+G+ P+ Sbjct: 197 AK------------GHNSTTNNELAFSPDM--EDIVRKYGMVLLEILTGR------VPSS 236 Query: 287 EEN--LVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVR-MASVAVQCLSFEPKSRPTMD 343 E++ L +W Y ++ ++D + + PE+ R + V C+ +PK RP M Sbjct: 237 EDDGPLENWVSRYFEGGMRLEELIDPSIG--FFPEDTARALCEVVRSCIDRDPKKRPQMK 294 Query: 344 QVVRALQQL 352 +V ++++ Sbjct: 295 EVAARMREI 303 >1AD5-A nrPDB Length = 438 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 87/329 (26%), Positives = 146/329 (44%), Gaps = 49/329 (14%) Query: 39 AQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDEST---LTPTK 95 QK +SS P K + + ++ + + + +G G FG V+ ++ T + K Sbjct: 156 CQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMK 215 Query: 96 PGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQK 155 PG+ ++ E F L E N + L H LVKL + E ++ EFM K Sbjct: 216 PGS--------MSVEAF------LAEANVMKTLQHDKLVKLHA-VVTKEPIYIITEFMAK 260 Query: 156 GSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN 215 GSL + L +PLP ++ + A+G+AF+ I+RD++A+NIL+ A Sbjct: 261 GSLLDFLKSDEGSKQPLPKL--IDFSAQIAEGMAFIEQR--NYIHRDLRAANILVSASLV 316 Query: 216 AKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 K++DFGLAR G + + APE ++ G +SDV+SFG+LL+EI++ Sbjct: 317 CKIADFGLARVGAKFPIKWT-----------APEAINFGSFTIKSDVWSFGILLMEIVTY 365 Query: 276 KRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFE 335 R + + + E + R Y + + PEE + ++ ++C Sbjct: 366 GR-IPYPGMSNPEVIRALERGYRMPR------------PENCPEE---LYNIMMRCWKNR 409 Query: 336 PKSRPTMDQVVRALQQLQDNLGKPSQTNP 364 P+ RPT + + L Q P Sbjct: 410 PEERPTFEYIQSVLDDFYTATESQYQQQP 438 >3BEA-A nrPDB Length = 333 Score = 95.9 bits (237), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 97/336 (28%), Positives = 143/336 (42%), Gaps = 58/336 (17%) Query: 45 EILSSTPVKSFTF---------NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTK 95 +I+ S S+TF + + N + +G G FG V ++ + K Sbjct: 17 KIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKV----VEATAFGLGK 72 Query: 96 PGTGLVIAVKKLNQEGFQGHREWLTE----INYLGQLSHPNLVKLIGYCLEDEHRLLVYE 151 L +AVK L +E L +++LGQ H N+V L+G C L++ E Sbjct: 73 EDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQ--HENIVNLLGACTHGGPVLVITE 130 Query: 152 FMQKGSLENHLFRRGAYFKPLPWFLRVNVAL----------DAAKGLAFLHSDPVKVIYR 201 + G L N L R+ + P F N L A+G+AFL S I+R Sbjct: 131 YCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASK--NCIHR 188 Query: 202 DIKASNILLDADYNAKLSDFGLARDGPMGDLSY-VSTRVMGTYGYAAPEYMSSGHLNARS 260 D+ A N+LL + AK+ DFGLARD M D +Y V + APE + +S Sbjct: 189 DVAARNVLLTNGHVAKIGDFGLARD-IMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQS 247 Query: 261 DVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY---LTSKRKVLLIVDNRLDTQ-- 315 DV+S+G+LL EI S L N PY L + + L+ D Q Sbjct: 248 DVWSYGILLWEIFS----LGLN-------------PYPGILVNSKFYKLVKDGYQMAQPA 290 Query: 316 YLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 + P+ + S+ C + EP RPT Q+ LQ+ Sbjct: 291 FAPK---NIYSIMQACWALEPTHRPTFQQICSFLQE 323 >6FEX-A nrPDB Length = 321 Score = 95.1 bits (235), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 77/296 (26%), Positives = 140/296 (47%), Gaps = 27/296 (9%) Query: 73 IGEGGFGCVFKGWLDE-----STLTP--TKPGTGLVIAVKKLNQEGFQGHR-EWLTEINY 124 +GEG FG V +D S P + G L++AVK L + + R ++L E+ Sbjct: 24 LGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKI 83 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHL--------FRRGAYFKP-LPWF 175 + +L PN+++L+G C++D+ ++ ++M+ G L L GA P + + Sbjct: 84 MSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDPTISYP 143 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 + ++VA A G+ +L + + ++RD+ N L+ ++ K++DFG++R+ GD V Sbjct: 144 MLLHVAAQIASGMRYLAT--LNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRV 201 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 R + + A E + G SDV++FGV L E+L RA + E+ + + Sbjct: 202 QGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGE 261 Query: 296 PYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 + R+V L P + + ++C S E + RP Q+ R L + Sbjct: 262 FFRDQGRQVYL--------SRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAE 309 >4E93-A nrPDB Length = 377 Score = 94.7 bits (234), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 87/289 (30%), Positives = 128/289 (44%), Gaps = 45/289 (15%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWLTEINYLGQLSHP 131 IG G FG VF G L ++AVK + + ++L E L Q SHP Sbjct: 122 IGRGNFGEVFSGRLR---------ADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHP 172 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL----DAAKG 187 N+V+LIG C + + +V E +Q G L GA LRV L DAA G Sbjct: 173 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGAR-------LRVKTLLQMVGDAAAG 225 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAA 247 + +L S I+RD+ A N L+ K+SDFG++R+ G + + A Sbjct: 226 MEYLESK--CCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTA 283 Query: 248 PEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLT-SKRKVLL 306 PE ++ G ++ SDV+SFG+LL E S A PY S ++ Sbjct: 284 PEALNYGRYSSESDVWSFGILLWETFSLG-----------------ASPYPNLSNQQTRE 326 Query: 307 IVDN--RLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQ 353 V+ RL L +AV + QC ++EP RP+ + + LQ ++ Sbjct: 327 FVEKGGRLPCPELCPDAV--FRLMEQCWAYEPGQRPSFSTIYQELQSIR 373 >4CSV-A nrPDB Length = 275 Score = 94.4 bits (233), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 80/283 (28%), Positives = 138/283 (48%), Gaps = 37/283 (13%) Query: 73 IGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 +G G FG V++G W + + + +AVK L +EG E+L E + +L HP Sbjct: 19 LGSGQFGEVYEGKWRNYN----------IEVAVKTL-KEGTMSVEEFLQEAQIMKKLKHP 67 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 NLV+L G C ++ ++ E+M GSL ++L R + +++A A G+A+L Sbjct: 68 NLVQLYGVCTKEPPIYIITEYMSHGSLLDYL--RDCEGHTVNAQALLDMAAQVASGMAYL 125 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY--GYAAPE 249 S I+RD+ A N L+ + K++DFGLAR + + + R + + APE Sbjct: 126 ESQ--NFIHRDLAARNCLVGENNVVKVADFGLAR---LINEDEYTARAGAKFPIKWTAPE 180 Query: 250 YMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVD 309 +S + +SDV++FG+LL EI + + + + + E + R Y + Sbjct: 181 AISYNRFSIKSDVWAFGILLWEIFTYGQ-VPYPGMSGSEVIEQVERGYRMPR-------- 231 Query: 310 NRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 Q PEE + + +QC + P+ RPT + + AL+ + Sbjct: 232 ----PQGCPEE---IYELMLQCWNKSPEERPTFAETLHALETM 267 >3ZBF-A nrPDB Length = 322 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 87/296 (29%), Positives = 144/296 (48%), Gaps = 38/296 (12%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLV-IAVKKLNQEGF-QGHREWLTEINYLGQLS 129 ++G G FG V++G + + G+G + +AVK L + Q E+L E + + + + Sbjct: 40 LLGSGAFGEVYEG----TAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFN 95 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHL--FRRGAYFKP-LPWFLRVNVALDAAK 186 HPN++K +G CL +E + ++ E M+ G L +L R ++ P L V++ +D +K Sbjct: 96 HPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISK 155 Query: 187 GLAFLHSDPVKVIYRDIKASNILLDA-DYNA----KLSDFGLARDGPMGDLSYVSTRVMG 241 G +L + I+RD+ A N L+ DY + K+ DFGLARD D + Sbjct: 156 GCVYLER--MHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLL 213 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK 301 + APE + G +SDV+SFG+L+ EIL+ L H NL Sbjct: 214 PVRWMAPESLMDGIFTTQSDVWSFGILIWEILT----LGHQPYPAHSNL----------- 258 Query: 302 RKVLLIVDN--RLD-TQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQD 354 VL V RL+ + P++ + ++ QC + EP RPT ++ LQ ++ Sbjct: 259 -DVLNYVQTGGRLEPPRNCPDD---LWNLMTQCWAQEPDQRPTFHRIQDQLQLFRN 310 >4PDO-A nrPDB Length = 299 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 80/288 (27%), Positives = 139/288 (48%), Gaps = 38/288 (13%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWLTEINYLGQLSH 130 VIG G FG V+KG L S+ P +A+K L + R ++L E +GQ SH Sbjct: 41 VIGAGEFGEVYKGMLKTSSGKKEVP-----VAIKTLKAGYTEKQRVDFLGEAGIMGQFSH 95 Query: 131 PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAF 190 N+++L G + + +++ E+M+ G+L+ L + F L V + A G+ + Sbjct: 96 HNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQ---LVGMLRGIAAGMKY 152 Query: 191 LHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR---DGPMGDLSYVSTRVMGTYGYAA 247 L + + ++RD+ A NIL++++ K+SDFGL+R D P + +Y ++ + A Sbjct: 153 LAN--MNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDP--EATYTTSGGKIPIRWTA 208 Query: 248 PEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLT-SKRKVLL 306 PE +S + SDV+SFG+++ E+++ RPY S +V+ Sbjct: 209 PEAISYRKFTSASDVWSFGIVMWEVMTYGE-----------------RPYWELSNHEVMK 251 Query: 307 IVDN--RLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 +++ RL T A+ + +QC E RP +V L +L Sbjct: 252 AINDGFRLPTPMDCPSAI--YQLMMQCWQQERARRPKFADIVSILDKL 297 >3COM-A nrPDB Length = 314 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 79/275 (28%), Positives = 128/275 (46%), Gaps = 33/275 (12%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +GEG +G V+K E TG ++A+K++ E +E + EI+ + Q P+ Sbjct: 37 LGEGSYGSVYKAIHKE---------TGQIVAIKQVPVES--DLQEIIKEISIMQQCDSPH 85 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 +VK G ++ +V E+ GS+ + + R K L + KGL +LH Sbjct: 86 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRN---KTLTEDEIATILQSTLKGLEYLH 142 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMS 252 ++ I+RDIKA NILL+ + +AKL+DFG+A G + D V+GT + APE + Sbjct: 143 F--MRKIHRDIKAGNILLNTEGHAKLADFGVA--GQLTDTMAKRNTVIGTPFWMAPEVIQ 198 Query: 253 SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRL 312 N +D++S G+ +E+ GK P + ++ P + RK L DN Sbjct: 199 EIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPP--PTFRKPELWSDNFT 256 Query: 313 DTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 D QCL P+ R T Q+++ Sbjct: 257 D-------------FVKQCLVKSPEQRATATQLLQ 278 >4E20-A nrPDB Length = 290 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 95/292 (32%), Positives = 131/292 (44%), Gaps = 28/292 (9%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE-GFQGHREWLTEINYLGQLSHP 131 +GEG FG V D PT GTG ++AVK L + G Q W EI L L H Sbjct: 16 LGEGHFGKVSLYCYD-----PTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHE 70 Query: 132 NLVKLIGYCLEDEHR---LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 ++VK G C ED+ LV E++ GSL ++L R L F A +G+ Sbjct: 71 HIVKYKG-CCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLF-----AQQICEGM 124 Query: 189 AFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT--YGYA 246 A+LH+ I+R + A N+LLD D K+ DFGLA+ P G Y R G + Sbjct: 125 AYLHAQ--HYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGH-EYYRVREDGDSPVFWY 181 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRP--AKEENLVDWARPYLTSKRKV 304 APE + SDV+SFGV L E+L+ D N+ K L+ + +T R Sbjct: 182 APECLKECKFYYASDVWSFGVTLYELLT---YCDSNQSPHTKFTELIGHTQGQMTVLRLT 238 Query: 305 LLIVDNRLDTQYLPEEA-VRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 L+ R + P+ + + C E RPT +V LQ Q+ Sbjct: 239 ELL--ERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPILQTAQEK 288 >6BSD-A nrPDB Length = 876 Score = 92.8 bits (229), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 82/350 (23%), Positives = 154/350 (44%), Gaps = 40/350 (11%) Query: 25 LSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFG----C 80 ++L +T A G + P F + L+ + +GEG FG C Sbjct: 538 VTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEK-------LGEGQFGEVHLC 590 Query: 81 VFKGWLDESTLT---PTKPGTGLVIAVKKLNQEGFQGHR-EWLTEINYLGQLSHPNLVKL 136 D +L + G L++AVK L + + R ++L E+ + +L PN+++L Sbjct: 591 EVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRL 650 Query: 137 IGYCLEDEHRLLVYEFMQKGSLE-----NHLFRRGAYFKP----------LPWFLRVNVA 181 +G C++D+ ++ ++M+ G L + L + A P + + + ++VA Sbjct: 651 LGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVA 710 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 A G+ +L + + ++RD+ N L+ ++ K++DFG++R+ GD V R + Sbjct: 711 AQIASGMRYLAT--LNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVL 768 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK 301 + A E + G SDV++FGV L E+L RA + E+ + + + Sbjct: 769 PIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQG 828 Query: 302 RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 R+V L P + + ++C S E + RP Q+ R L + Sbjct: 829 RQVYL--------SRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAE 870 >1JPA-A nrPDB Length = 312 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 70/243 (28%), Positives = 121/243 (49%), Gaps = 31/243 (12%) Query: 52 VKSFTFNELKLATRNF---------RPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVI 102 + FTF + A R F + + VIG G FG V G L PG + Sbjct: 11 IDPFTFEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHL-------KLPGKREIF 63 Query: 103 AVKKLNQEGF--QGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLEN 160 K + G+ + R++L+E + +GQ HPN++ L G + +++ EFM+ GSL++ Sbjct: 64 VAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDS 123 Query: 161 HLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSD 220 L + F + V + A G+ +L + ++RD+ A NIL++++ K+SD Sbjct: 124 FLRQNDGQFTVIQ---LVGMLRGIAAGMKYLAD--MNYVHRDLAARNILVNSNLVCKVSD 178 Query: 221 FGLAR--DGPMGDLSYVSTRVMG---TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS- 274 FGL+R + D +Y S +G + APE + + SDV+S+G+++ E++S Sbjct: 179 FGLSRFLEDDTSDPTYTSA--LGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSY 236 Query: 275 GKR 277 G+R Sbjct: 237 GER 239 >5X5O-A nrPDB Length = 310 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 83/311 (26%), Positives = 146/311 (46%), Gaps = 46/311 (14%) Query: 56 TFNELKLATRNFRPDSVIGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQEGFQG 114 +F ++K F + G G FG V++ W+ + +AVKKL + Sbjct: 8 SFVQIKFDDLQFFENC--GGGSFGSVYRAKWISQDK----------EVAVKKLLKIE--- 52 Query: 115 HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPW 174 E L LSH N+++ G LE + +V E+ GSL +++ + + Sbjct: 53 -----KEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDH 107 Query: 175 FLRVNVALDAAKGLAFLHSD-PVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 + A D AKG+ +LH + PVKVI+RD+K+ N+++ AD K+ DFG +R + Sbjct: 108 IM--TWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFH--NHTT 163 Query: 234 YVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDW 293 ++S ++GT+ + APE + S ++ D YS+GV+L E+L+ R + L Sbjct: 164 HMS--LVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLT--------REVPFKGLEGL 213 Query: 294 ARPYLTSKRKVLLIVDNRLDTQYLPEEAVR-MASVAVQCLSFEPKSRPTMDQVVRALQQL 352 +L ++ + RL +P R A + QC + K RP+ Q++ L+ + Sbjct: 214 QVAWLVVEK------NERLT---IPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESM 264 Query: 353 QDNLGKPSQTN 363 ++ P + N Sbjct: 265 SNDTSLPDKCN 275 >2OGV-A nrPDB Length = 317 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 95/332 (28%), Positives = 144/332 (43%), Gaps = 54/332 (16%) Query: 45 EILSSTPVKSFTF---------NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTK 95 +I+ S S+TF + + N + +G G FG V ++ + K Sbjct: 9 KIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKV----VEATAFGLGK 64 Query: 96 PGTGLVIAVKKLNQEGFQGHREWLTE----INYLGQLSHPNLVKLIGYCLEDEHRLLVYE 151 L +AVK L +E L +++LGQ H N+V L+G C L++ E Sbjct: 65 EDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQ--HENIVNLLGACTHGGPVLVITE 122 Query: 152 FMQKGSLENHLFRRGAY------FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKA 205 + G L N L R+ +PL ++ + A+G+AFL S I+RD+ A Sbjct: 123 YCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASK--NCIHRDVAA 180 Query: 206 SNILLDADYNAKLSDFGLARDGPMGDLSY-VSTRVMGTYGYAAPEYMSSGHLNARSDVYS 264 N+LL + AK+ DFGLARD M D +Y V + APE + +SDV+S Sbjct: 181 RNVLLTNGHVAKIGDFGLARD-IMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWS 239 Query: 265 FGVLLLEILSGKRALDHNRPAKEENLVDWARPY---LTSKRKVLLIVDNRLDTQ--YLPE 319 +G+LL EI S L N PY L + + L+ D Q + P+ Sbjct: 240 YGILLWEIFS----LGLN-------------PYPGILVNSKFYKLVKDGYQMAQPAFAPK 282 Query: 320 EAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 + S+ C + EP RPT Q+ LQ+ Sbjct: 283 ---NIYSIMQACWALEPTHRPTFQQICSFLQE 311 >2VWV-A nrPDB Length = 302 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 76/292 (26%), Positives = 136/292 (46%), Gaps = 35/292 (11%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF--QGHREWLTEINYLGQ 127 + VIG G FG V +G L P K + +A+K L + G+ + RE+L+E + +GQ Sbjct: 21 EEVIGAGEFGEVCRGRLK----APGKKES--CVAIKTL-KGGYTERQRREFLSEASIMGQ 73 Query: 128 LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 HPN+++L G +++ EFM+ G+L++ L F + V + A G Sbjct: 74 FEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQL---VGMLRGIASG 130 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG---TYG 244 + +L + ++RD+ A NIL++++ K+SDFGL+R T +G Sbjct: 131 MRYLAE--MSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIR 188 Query: 245 YAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL-TSKRK 303 + APE ++ + SD +S+G+++ E++S RPY S + Sbjct: 189 WTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGE-----------------RPYWDMSNQD 231 Query: 304 VLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 V+ ++ P+ + + + C + +RP QVV AL ++ N Sbjct: 232 VINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRN 283 >4XCU-A nrPDB Length = 300 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 80/285 (28%), Positives = 132/285 (46%), Gaps = 25/285 (8%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF-QGHREWLTEINYLGQLS-H 130 +GEG FG V + + + P +P +AVK L + + ++E+ + + H Sbjct: 25 LGEGCFGQVVRA--EAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRH 82 Query: 131 PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR---GAYFKPLPWFLRVNVALDAAKG 187 N++ L+G C ++ ++ E KG+L L R G+ PL + + V+ A A+G Sbjct: 83 KNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAYQVARG 142 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAA 247 + +L S K I+RD+ A N+L+ D K++DFGLAR D ++ + A Sbjct: 143 MQYLESR--KCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMA 200 Query: 248 PEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLI 307 PE + +SDV+SFG+LL EI + + P +E L S LL Sbjct: 201 PEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEE----------LFS----LLR 246 Query: 308 VDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 +R+D P + + +C P RPT Q+V AL ++ Sbjct: 247 EGHRMDRP--PHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKV 289 >4NEU-A nrPDB Length = 333 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 80/308 (25%), Positives = 143/308 (46%), Gaps = 56/308 (18%) Query: 55 FTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG 114 + N +K+ + +F + + GGFG V S G ++ V K + Sbjct: 14 MSLNVIKMKSSDFLESAELDSGGFGKV-------SLCFHRTQGLMIMKTVYK-GPNCIEH 65 Query: 115 HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPW 174 + L E + +L H +VKL+G +E+ LV E+M+KG+L H+ + P Sbjct: 66 NEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNL-MHVLKAEM---STPL 121 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLA---------- 224 ++ + L+ +G+ +LH VI++D+K NIL+D D++ K++D GLA Sbjct: 122 SVKGRIILEIIEGMCYLHGK--GVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNN 179 Query: 225 -RDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNA----RSDVYSFGVLLLEILSGKRAL 279 + ++ + + GT Y APE+++ +NA +SDVYSF V+L I + K Sbjct: 180 EEHNELREVDGTAKKNGGTLYYMAPEHLND--VNAKPTEKSDVYSFAVVLWAIFANKEPY 237 Query: 280 DHNRPAKEENLVDWARPYLTSKRKVLLIVD--NRLD----TQYLPEEAVRMASVAVQCLS 333 EN + ++++++ + NR D T+Y P E + + + C Sbjct: 238 --------ENAI--------CEQQLIMCIKSGNRPDVDDITEYCPREIISLMKL---CWE 278 Query: 334 FEPKSRPT 341 P++RPT Sbjct: 279 ANPEARPT 286 >4YFF-A nrPDB Length = 311 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 65/231 (28%), Positives = 118/231 (51%), Gaps = 22/231 (9%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE- 117 L+L+ F +IG G FG V+KG ++A+K+ + + Sbjct: 38 HLQLSEIEFH--EIIGSGSFGKVYKGRCRNK-----------IVAIKRYRANTYCSKSDV 84 Query: 118 --WLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLPW 174 + E++ L QL+HP +++ +G CL D + +V +++ GSL + L + + L Sbjct: 85 DMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQK---RILDL 141 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSY 234 ++ +A+D AKG+ +LH+ +I+RD+ + NILL D +A ++DFG +R D Sbjct: 142 QSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDN 201 Query: 235 VSTRVMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRP 284 + T+ G + APE + ++DV+S+ + L EIL+G+ H +P Sbjct: 202 M-TKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKP 251 >5VO2-A nrPDB Length = 300 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 71/249 (28%), Positives = 127/249 (51%), Gaps = 36/249 (14%) Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 T+I +L +L HPN++ G C + ++ EF +G L + R G +P+ L V+ Sbjct: 49 TDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQL-YEVLRAG---RPVTPSLLVD 104 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 ++ A G+ +LH K+I+RD+K+ N+L+ D K+SDFG +++ LS ST++ Sbjct: 105 WSMGIAGGMNYLHLH--KIIHRDLKSPNMLITYDDVVKISDFGTSKE-----LSDKSTKM 157 Query: 240 --MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY 297 GT + APE + + ++ + D++SFGV+L E+L+G+ P K+ Sbjct: 158 SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGE------IPYKD---------- 201 Query: 298 LTSKRKVLLIVDNRLDTQYLPEEAVRMASVAV---QCLSFEPKSRPTMDQVVRALQQLQ- 353 + S + + N L +LP + + QC + +P++RP+ Q++ L Sbjct: 202 VDSSAIIWGVGSNSL---HLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASA 258 Query: 354 DNLGKPSQT 362 D L P +T Sbjct: 259 DVLSTPQET 267 >4R7H-A nrPDB Length = 343 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 95/345 (27%), Positives = 144/345 (41%), Gaps = 67/345 (19%) Query: 45 EILSSTPVKSFTF---------NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTK 95 +I+ S S+TF + + N + +G G FG V ++ + K Sbjct: 21 KIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKV----VEATAFGLGK 76 Query: 96 PGTGLVIAVKKLNQEGFQGHREWLTE----INYLGQLSHPNLVKLIGYCLEDEHRLLVYE 151 L +AVK L +E L +++LGQ H N+V L+G C L++ E Sbjct: 77 EDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQ--HENIVNLLGACTHGGPVLVITE 134 Query: 152 FMQKGSLENHLFRRGAYF-------------------KPLPWFLRVNVALDAAKGLAFLH 192 + G L N L R+ +PL ++ + A+G+AFL Sbjct: 135 YCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLA 194 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSY-VSTRVMGTYGYAAPEYM 251 S I+RD+ A N+LL + AK+ DFGLARD M D +Y V + APE + Sbjct: 195 SK--NCIHRDVAARNVLLTNGHVAKIGDFGLARD-IMNDSNYIVKGNARLPVKWMAPESI 251 Query: 252 SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY---LTSKRKVLLIV 308 +SDV+S+G+LL EI S L N PY L + + L+ Sbjct: 252 FDSVYTVQSDVWSYGILLWEIFS----LGLN-------------PYPGILVNSKFYKLVK 294 Query: 309 DNRLDTQ--YLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 D Q + P+ + S+ C + EP RPT Q+ LQ+ Sbjct: 295 DGYQMAQPAFAPK---NIYSIMQACWALEPTHRPTFQQITSFLQE 336 >2H8H-A nrPDB Length = 535 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 81/288 (28%), Positives = 132/288 (45%), Gaps = 43/288 (14%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDEST---LTPTKPGTGLVIAVKKLNQEGFQGHRE 117 ++ + R + +G+G FG V+ G + +T + KPGT ++ E F Sbjct: 263 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGT--------MSPEAF----- 309 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 L E + +L H LV+L + +E +V E+M KGSL + L + LP Sbjct: 310 -LQEAQVMKKLRHEKLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQL-- 365 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 V++A A G+A++ + ++RD++A+NIL+ + K++DFGLAR + D Y + Sbjct: 366 VDMAAQIASGMAYVER--MNYVHRDLRAANILVGENLVCKVADFGLARL--IEDNEYTAR 421 Query: 238 R-VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 + + APE G +SDV+SFG+LL E+ + R P Sbjct: 422 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRV-----------------P 464 Query: 297 YL-TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMD 343 Y R+VL V+ PE + + QC EP+ RPT + Sbjct: 465 YPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFE 512 >2HK5-A nrPDB Length = 270 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 80/285 (28%), Positives = 133/285 (46%), Gaps = 41/285 (14%) Query: 73 IGEGGFGCVFKGWLDEST---LTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLS 129 +G G FG V+ ++ T + KPG+ ++ E F L E N + L Sbjct: 23 LGAGQFGEVWMATYNKHTKVAVKTMKPGS--------MSVEAF------LAEANVMKTLQ 68 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 H LVKL + E ++ EFM KGSL + L +PLP ++ + A+G+A Sbjct: 69 HDKLVKLHA-VVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKL--IDFSAQIAEGMA 125 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR-VMGTYGYAAP 248 F+ I+RD++A+NIL+ A K++DFGLAR + D Y + + AP Sbjct: 126 FIEQR--NYIHRDLRAANILVSASLVCKIADFGLAR--VIEDNEYTAREGAKFPIKWTAP 181 Query: 249 EYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIV 308 E ++ G +SDV+SFG+LL+EI++ R + + + E + R Y + Sbjct: 182 EAINFGSFTIKSDVWSFGILLMEIVTYGR-IPYPGMSNPEVIRALERGYRMPR------- 233 Query: 309 DNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQ 353 + PEE + ++ ++C P+ RPT + + L + Sbjct: 234 -----PENCPEE---LYNIMMRCWKNRPEERPTFEYIQSVLDDFE 270 >3I81-A nrPDB Length = 315 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 77/311 (24%), Positives = 145/311 (46%), Gaps = 49/311 (15%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR- 116 +E ++A +G+G FG V++G + +P T +A+K +N+ R Sbjct: 11 DEWEVAREKITMSRELGQGSFGMVYEG--VAKGVVKDEPETR--VAIKTVNEAASMRERI 66 Query: 117 EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHL------FRRGAYFK 170 E+L E + + + + ++V+L+G + + L++ E M +G L+++L Sbjct: 67 EFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLA 126 Query: 171 PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMG 230 P + +A + A G+A+L+++ K ++RD+ A N ++ D+ K+ DFG+ RD Sbjct: 127 PPSLSKMIQMAGEIADGMAYLNAN--KFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYET 184 Query: 231 DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEI----------LSGKRALD 280 D + + + +PE + G SDV+SFGV+L EI LS ++ L Sbjct: 185 DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVL- 243 Query: 281 HNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP 340 R E L+D +P DN D + E +RM C + PK RP Sbjct: 244 --RFVMEGGLLD--KP------------DNCPDMLF---ELMRM------CWQYNPKMRP 278 Query: 341 TMDQVVRALQQ 351 + +++ ++++ Sbjct: 279 SFLEIISSIKE 289 >6FER-A nrPDB Length = 309 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 71/299 (23%), Positives = 137/299 (45%), Gaps = 30/299 (10%) Query: 73 IGEGGFG----CVFKG---WLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWLTEINY 124 +GEG FG C +G + D+ +++AVK L + + R ++L EI Sbjct: 17 LGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKI 76 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR------GAYFKPLPWFLRV 178 + +L PN++ L+ C+ D+ ++ E+M+ G L L R + + + + Sbjct: 77 MSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLK 136 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR 238 +A A G+ +L S + ++RD+ N L+ +Y K++DFG++R+ GD + R Sbjct: 137 FMATQIASGMKYLSS--LNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGR 194 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 + + + E + G SDV++FGV L E + + +++ + E+ + + + Sbjct: 195 AVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFR 254 Query: 299 TSKRKVLLIVDNRLDTQYLPEEAVRMASV---AVQCLSFEPKSRPTMDQVVRALQQLQD 354 R+ YLP+ A+ SV + C + K+RP+ ++ L Q D Sbjct: 255 DQGRQT-----------YLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQQGD 302 >5L6P-A nrPDB Length = 298 Score = 89.0 bits (219), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 65/217 (29%), Positives = 116/217 (53%), Gaps = 24/217 (11%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF--QGHREWLTEINYLGQ 127 + VIG G FG V +G L + PG V K + G+ + R++L+E + +GQ Sbjct: 24 EEVIGAGEFGEVCRGRLKQ-------PGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQ 76 Query: 128 LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 HPN+++L G + +++ EFM+ +L++ L F + V + A G Sbjct: 77 FDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQL---VGMLRGIAAG 133 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR---DGPMGDLSYVSTRVMG--- 241 + +L + ++RD+ A NIL++++ K+SDFGL+R D P D +Y S+ +G Sbjct: 134 MKYLSE--MNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDP-SDPTYTSS--LGGKI 188 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKR 277 + APE ++ + SDV+S+G+++ E++S G+R Sbjct: 189 PIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGER 225 >3DKO-A nrPDB Length = 318 Score = 89.0 bits (219), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 78/299 (26%), Positives = 133/299 (44%), Gaps = 33/299 (11%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 +L + + VIG G FG V G L P K + I K+ Q R++L Sbjct: 39 ELDASCIKIERVIGAGEFGEVCSGRLK----LPGKRDVAVAIKTLKVGYTEKQ-RRDFLC 93 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 E + +GQ HPN+V L G + ++V EFM+ G+L+ L + F + V + Sbjct: 94 EASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQL---VGM 150 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR---DGPMGDLSYVST 237 A G+ +L + ++RD+ A NIL++++ K+SDFGL+R D P + Y +T Sbjct: 151 LRGIAAGMRYLAD--MGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDP--EAVYTTT 206 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY 297 + APE + + SDV+S+G+++ E++S RPY Sbjct: 207 GGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGE-----------------RPY 249 Query: 298 L-TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 S + V+ ++ + + + + C E RP +Q+V L ++ N Sbjct: 250 WDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIRN 308 >2R2P-A nrPDB Length = 295 Score = 89.0 bits (219), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 80/293 (27%), Positives = 140/293 (47%), Gaps = 39/293 (13%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGT-GLVIAVKKLNQEGF--QGHREWLTEINYLG 126 + VIG G FG V G L PG L +A+K L + G+ + R++L E + +G Sbjct: 27 ERVIGAGEFGEVCSGRL-------KLPGKRELPVAIKTL-KVGYTEKQRRDFLGEASIMG 78 Query: 127 QLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAK 186 Q HPN++ L G + + ++V E+M+ GSL+ L + F + V + + Sbjct: 79 QFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQ---LVGMLRGISA 135 Query: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR---DGPMGDLSYVSTRVMGTY 243 G+ +L SD + ++RD+ A NIL++++ K+SDFGL+R D P + +Y + Sbjct: 136 GMKYL-SD-MGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDP--EAAYTTRGGKIPI 191 Query: 244 GYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL-TSKR 302 + APE ++ + SDV+S+G+++ E++S RPY + + Sbjct: 192 RWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGE-----------------RPYWEMTNQ 234 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 V+ V+ + + + + C E SRP D++V L +L N Sbjct: 235 DVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRN 287 >5H2U-A nrPDB Length = 267 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 65/203 (32%), Positives = 106/203 (52%), Gaps = 18/203 (8%) Query: 73 IGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 +G G FG VF+G W D + +A+K ++++ + +EI + +L H Sbjct: 14 LGSGYFGEVFEGLWKDR-----------VQVAIKVISRDNLLHQQMLQSEIQAMKKLRHK 62 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 +++ L + ++ E M KGSL L R + K LP +++A A+G+ +L Sbjct: 63 HILALYAVVSVGDPVYIITELMAKGSLLELL--RDSDEKVLPVSELLDIAWQVAEGMCYL 120 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM 251 S I+RD+ A NIL+ + K+ DFGLAR + + Y+S Y + APE + Sbjct: 121 ESQ--NYIHRDLAARNILVGENTLCKVGDFGLAR--LIKEDVYLSHDHNIPYKWTAPEAL 176 Query: 252 SSGHLNARSDVYSFGVLLLEILS 274 S GH + +SDV+SFG+LL E+ S Sbjct: 177 SRGHYSTKSDVWSFGILLHEMFS 199 >6AO5-A nrPDB Length = 362 Score = 88.2 bits (217), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 65/204 (31%), Positives = 104/204 (50%), Gaps = 18/204 (8%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +GEG +G VFK ES G V+A+K++ E +E + EI+ + Q P Sbjct: 18 LGEGSYGSVFKAIHKES---------GQVVAIKQVPVES--DLQEIIKEISIMQQCDSPY 66 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 +VK G ++ +V E+ GS+ + + R K L + KGL +LH Sbjct: 67 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRN---KTLIEDEIATILKSTLKGLEYLH 123 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMS 252 ++ I+R+IKA NILL+ + +AKL+DFG+A G + D V+GT + APE + Sbjct: 124 F--MRKIHRNIKAGNILLNTEGHAKLADFGVA--GQLTDTMAKRNTVIGTPFWMAPEVIQ 179 Query: 253 SGHLNARSDVYSFGVLLLEILSGK 276 N +D++S G+ +E+ GK Sbjct: 180 EIGYNCVADIWSLGITSIEMAEGK 203 >5AMN-A nrPDB Length = 299 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 93/300 (31%), Positives = 138/300 (46%), Gaps = 39/300 (13%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLV-IAVKKLNQEGFQGH-REWLTEI 122 +N +GEG FG V K +T K G +AVK L + R+ L+E Sbjct: 23 KNLVLGKTLGEGEFGKVVK-----ATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEF 77 Query: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKP-------LPWF 175 N L Q++HP+++KL G C +D LL+ E+ + GSL L R P L Sbjct: 78 NVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFL-RESRKVGPGYPDERALTMG 136 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 ++ A ++G+ +L +K+++RD+ A NIL+ K+SDFGL+RD D SYV Sbjct: 137 DLISFAWQISQGMQYLAE--MKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED-SYV 193 Query: 236 STRVMG--TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVD 292 R G + A E + +SDV+SFGVLL EI++ G P + NL+ Sbjct: 194 K-RSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 252 Query: 293 WARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 T R R D EE R+ +QC EP RP + + L+++ Sbjct: 253 ------TGHRM------ERPDN--CSEEMYRL---MLQCWKQEPDKRPVFADISKDLEKM 295 >2PL0-A nrPDB Length = 289 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 87/308 (28%), Positives = 142/308 (46%), Gaps = 43/308 (13%) Query: 48 SSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL 107 + P K + +E ++ + +G G FG V+ G+ + T +AVK L Sbjct: 6 TQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT----------KVAVKSL 55 Query: 108 NQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGA 167 Q G +L E N + QL H LV+L + E ++ E+M+ GSL + L + + Sbjct: 56 KQ-GSMSPDAFLAEANLMKQLQHQRLVRLYA-VVTQEPIYIITEYMENGSLVDFL-KTPS 112 Query: 168 YFKPLPWFLRVNVALDAA----KGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGL 223 K L +N LD A +G+AF+ I+RD++A+NIL+ + K++DFGL Sbjct: 113 GIK-----LTINKLLDMAAQIAEGMAFIEER--NYIHRDLRAANILVSDTLSCKIADFGL 165 Query: 224 ARDGPMGDLSYVSTR-VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHN 282 AR + D Y + + APE ++ G +SDV+SFG+LL EI++ R + + Sbjct: 166 AR--LIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGR-IPYP 222 Query: 283 RPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTM 342 E + + R Y + DN PEE ++ + C P+ RPT Sbjct: 223 GMTNPEVIQNLERGYRMVRP------DN------CPEELYQLMRL---CWKERPEDRPTF 267 Query: 343 DQVVRALQ 350 D + L+ Sbjct: 268 DYLRSVLE 275 >3KUL-B nrPDB Length = 325 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 67/214 (31%), Positives = 112/214 (52%), Gaps = 20/214 (9%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF--QGHREWLTEINYLGQ 127 + +IG G G V G L PG V K + G+ + R++L+E + +GQ Sbjct: 54 EKIIGSGDSGEVCYGRL-------RVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQ 106 Query: 128 LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 HPN+++L G ++V E+M+ GSL+ L F + V + G Sbjct: 107 FDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQL---VGMLRGVGAG 163 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR---DGPMGDLSYVSTRVMGTYG 244 + +L SD + ++RD+ A N+L+D++ K+SDFGL+R D P D +Y +T Sbjct: 164 MRYL-SD-LGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDP--DAAYTTTGGKIPIR 219 Query: 245 YAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKR 277 + APE ++ ++ SDV+SFGV++ E+L+ G+R Sbjct: 220 WTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGER 253 >4XLV-A nrPDB Length = 328 Score = 87.8 bits (216), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 81/289 (28%), Positives = 135/289 (46%), Gaps = 37/289 (12%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWLTEINYLGQLSHP 131 +G+G FG V++G + K +AVK +N+ R E+L E + + + Sbjct: 47 LGQGSFGMVYEG----NARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCH 102 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHL--FRRGAYFKP--LPWFLR--VNVALDAA 185 ++V+L+G + + L+V E M G L+++L R A P P L+ + +A + A Sbjct: 103 HVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIA 162 Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGY 245 G+A+L++ K ++RD+ A N ++ D+ K+ DFG+ RD D + + + Sbjct: 163 DGMAYLNAK--KFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW 220 Query: 246 AAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL-TSKRKV 304 APE + G SD++SFGV+L EI S +PY S +V Sbjct: 221 MAPESLKDGVFTTSSDMWSFGVVLWEITSLAE-----------------QPYQGLSNEQV 263 Query: 305 LLIVDNRLDTQYL--PEEAV-RMASVAVQCLSFEPKSRPTMDQVVRALQ 350 L V +D YL P+ R+ + C F P RPT ++V L+ Sbjct: 264 LKFV---MDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLK 309 >6F3F-A nrPDB Length = 455 Score = 87.8 bits (216), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 80/288 (27%), Positives = 132/288 (45%), Gaps = 43/288 (14%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDEST---LTPTKPGTGLVIAVKKLNQEGFQGHRE 117 ++ + R + +G+G FG V+ G + +T + KPGT ++ E F Sbjct: 183 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGT--------MSPEAF----- 229 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 L E + +L H LV+L + +E +V E+M KGSL + L + LP Sbjct: 230 -LQEAQVMKKLRHEKLVQLYA-VVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQL-- 285 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 V+++ A G+A++ + ++RD++A+NIL+ + K++DFGLAR + D Y + Sbjct: 286 VDMSAQIASGMAYVER--MNYVHRDLRAANILVGENLVCKVADFGLAR--LIEDNEYTAR 341 Query: 238 R-VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 + + APE G +SDV+SFG+LL E+ + R P Sbjct: 342 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRV-----------------P 384 Query: 297 YL-TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMD 343 Y R+VL V+ PE + + QC EP+ RPT + Sbjct: 385 YPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFE 432 >4LG4-A nrPDB Length = 299 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 78/276 (28%), Positives = 125/276 (45%), Gaps = 35/276 (12%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +GEG +G VFK ES G V+A+K++ E +E + EI+ + Q P Sbjct: 19 LGEGSYGSVFKAIHKES---------GQVVAIKQVPVES--DLQEIIKEISIMQQCDSPY 67 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 +VK G ++ +V E+ GS+ + + R K L + KGL +LH Sbjct: 68 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRN---KTLIEDEIATILKSTLKGLEYLH 124 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMS 252 ++ I+R+IKA NILL+ + +AKL+DFG+A G + D V+GT + APE + Sbjct: 125 F--MRKIHRNIKAGNILLNTEGHAKLADFGVA--GQLTDTMAKRNTVIGTPFWMAPEVIQ 180 Query: 253 SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRL 312 N +D++S G+ +E+ GK P R + +I N Sbjct: 181 EIGYNCVADIWSLGITSIEMAEGKPPYADIHPM----------------RAIFMIPTNPP 224 Query: 313 DTQYLPE-EAVRMASVAVQCLSFEPKSRPTMDQVVR 347 T PE + +CL P+ R T Q+++ Sbjct: 225 PTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQ 260 >2Y6O-A nrPDB Length = 291 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 74/292 (25%), Positives = 137/292 (46%), Gaps = 37/292 (12%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF--QGHREWLTEINYLGQ 127 + VIG G FG V G L P K + +A+K L + G+ + R++L+E + +GQ Sbjct: 19 EKVIGVGEFGEVCSGRLK----VPGK--REICVAIKTL-KAGYTDKQRRDFLSEASIMGQ 71 Query: 128 LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 HPN++ L G + + +++ E+M+ GSL+ L + F + V + G Sbjct: 72 FDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQL---VGMLRGIGSG 128 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR---DGPMGDLSYVSTRVMGTYG 244 + +L + ++RD+ A NIL++++ K+SDFG++R D P + +Y + Sbjct: 129 MKYLSD--MSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDP--EAAYTTRGGKIPIR 184 Query: 245 YAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL-TSKRK 303 + APE ++ + SDV+S+G+++ E++S RPY S + Sbjct: 185 WTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGE-----------------RPYWDMSNQD 227 Query: 304 VLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 V+ ++ + + + + + C E RP Q+V L +L N Sbjct: 228 VIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRN 279 >3OMV-A nrPDB Length = 307 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 78/309 (25%), Positives = 142/309 (45%), Gaps = 48/309 (15%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR 116 +E+ L+TR IG G FG V+KG W + + ++ V E FQ R Sbjct: 36 SEVMLSTR-------IGSGSFGTVYKGKWHGDVAVK--------ILKVVDPTPEQFQAFR 80 Query: 117 EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 E+ L + H N++ +GY +D + +V ++ + SL HL + F+ F Sbjct: 81 ---NEVAVLRKTRHVNILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQ---MFQ 133 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 +++A A+G+ +LH+ +I+RD+K++NI L K+ DFGLA S Sbjct: 134 LIDIARQTAQGMDYLHAK--NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQV 191 Query: 237 TRVMGTYGYAAPEYMSSGHLNA---RSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDW 293 + G+ + APE + N +SDVYS+G++L E+++G+ H Sbjct: 192 EQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSH------------ 239 Query: 294 ARPYLTSKRKVLLIVDNRL---DTQYLPEEAVR-MASVAVQCLSFEPKSRPTMDQVVRAL 349 + ++ +++ +V D L + + M + C+ + RP Q++ ++ Sbjct: 240 ----INNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSI 295 Query: 350 QQLQDNLGK 358 + LQ +L K Sbjct: 296 ELLQHSLPK 304 >5MJB-A nrPDB Length = 305 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 74/297 (24%), Positives = 139/297 (46%), Gaps = 45/297 (15%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF--QGHREWLTEINYLGQ 127 + VIG G FG V+KG L PG + K + G+ + R++L+E + +GQ Sbjct: 31 EEVIGAGEFGEVYKGRL-------KLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQ 83 Query: 128 LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 H N+++L G + +++ EFM+ +L++ L + F + V + A G Sbjct: 84 FDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVIQL---VGMLRGIAAG 140 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR--DGPMGDLSYVSTRVMG---T 242 + +L + ++RD+ A NIL++++ K+SDFGL+R D +Y S+ +G Sbjct: 141 MKYLSE--MNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSS--LGGKIP 196 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 + APE ++ + SDV+S+G+++ E++S RPY Sbjct: 197 VRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGE-----------------RPYWDMSN 239 Query: 303 KVLLIVDNRLDTQY-LP---EEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 + ++ N ++ Y LP + + + + C + SRP ++V L ++ N Sbjct: 240 QDVI---NAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRN 293 >3V5Q-A nrPDB Length = 297 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 78/299 (26%), Positives = 129/299 (43%), Gaps = 48/299 (16%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +GEG FG VF + L+PTK +++AVK L +++ E L L H + Sbjct: 23 LGEGAFGKVFLA--ECYNLSPTK--DKMLVAVKALKDPTLAARKDFQREAELLTNLQHEH 78 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL---------------- 176 +VK G C + + ++V+E+M+ G L L G P L Sbjct: 79 IVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHG----PDAMILVDGQPRQAKGELGLSQ 134 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 +++A A G+ +L S ++RD+ N L+ A+ K+ DFG++RD D V Sbjct: 135 MLHIASQIASGMVYLASQ--HFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVG 192 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWAR 295 M + PE + SDV+SFGV+L EI + GK+ W + Sbjct: 193 GHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQP--------------WFQ 238 Query: 296 PYLTSKRKVLLIVDNRL--DTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 L++ + I R+ + P+E + V + C EP+ R + ++ + L L Sbjct: 239 --LSNTEVIECITQGRVLERPRVCPKE---VYDVMLGCWQREPQQRLNIKEIYKILHAL 292 >3PLS-A nrPDB Length = 298 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 87/293 (29%), Positives = 135/293 (46%), Gaps = 43/293 (14%) Query: 70 DSVIGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQ-EGFQGHREWLTEINYLGQ 127 D VIG+G FG V+ G ++D++ + A+K L++ Q +L E + Sbjct: 26 DRVIGKGHFGVVYHGEYIDQAQ-------NRIQCAIKSLSRITEMQQVEAFLREGLLMRG 78 Query: 128 LSHPNLVKLIGYCLEDE---HRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 L+HPN++ LIG L E H LL Y M G L F R P L ++ L Sbjct: 79 LNHPNVLALIGIMLPPEGLPHVLLPY--MCHGDLLQ--FIRSPQRNPTVKDL-ISFGLQV 133 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR----VM 240 A+G+ +L K ++RD+ A N +LD + K++DFGLARD + D Y S + Sbjct: 134 ARGMEYLAEQ--KFVHRDLAARNCMLDESFTVKVADFGLARD--ILDREYYSVQQHRHAR 189 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLT 299 + A E + + +SDV+SFGVLL E+L+ G H P + +L Sbjct: 190 LPVKWTALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTH-------FLA 242 Query: 300 SKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 R++ +Y P+ + V QC +P RPT +V ++Q+ Sbjct: 243 QGRRL-------PQPEYCPDS---LYQVMQQCWEADPAVRPTFRVLVGEVEQI 285 >2Z7Q-A nrPDB Length = 321 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 68/213 (31%), Positives = 112/213 (52%), Gaps = 18/213 (8%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEI--N 123 +F V+G+G FG VF T+P +G + A+K L + + T++ + Sbjct: 29 HFELLKVLGQGSFGKVF------LVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERD 82 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 L ++HP +VKL Y + E +L L+ +F++ G L L + + + F +AL Sbjct: 83 ILADVNHPFVVKL-HYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 141 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 GL LHS + +IYRD+K NILLD + + KL+DFGL+++ D + GT Sbjct: 142 ----GLDHLHS--LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGT 193 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 Y APE ++ + +D +S+GVL+ E+L+G Sbjct: 194 VEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTG 226 >5U6C-A nrPDB Length = 315 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 80/298 (26%), Positives = 139/298 (46%), Gaps = 41/298 (13%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVK--KLNQEGFQGHREWLTEINYLGQLS 129 ++GEG FG V +G L + + GT L +AVK KL+ + E+L+E + S Sbjct: 43 ILGEGEFGSVMEGNLKQ------EDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFS 96 Query: 130 HPNLVKLIGYCLEDEHR-----LLVYEFMQKGSLENHL----FRRGAYFKPLPWFLRVNV 180 HPN+++L+G C+E + +++ FM+ G L +L G PL L+ V Sbjct: 97 HPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMV 156 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 D A G+ +L + ++RD+ A N +L D ++DFGL++ GD Y R+ Sbjct: 157 --DIALGMEYLSNR--NFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDY-YRQGRIA 211 Query: 241 GT-YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLT 299 + A E ++ ++SDV++FGV + EI R + + + D+ Sbjct: 212 KMPVKWIAIESLADRVYTSKSDVWAFGVTMWEI--ATRGMTPYPGVQNHEMYDY------ 263 Query: 300 SKRKVLLIVDNRLDTQYLPEEAV-RMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNL 356 L+ +RL PE+ + + + C +P RPT + L++L ++L Sbjct: 264 ------LLHGHRLKQ---PEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESL 312 >3IO7-A nrPDB Length = 313 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 67/226 (29%), Positives = 110/226 (48%), Gaps = 21/226 (9%) Query: 56 TFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH 115 + N + R+ + +G+G FG V + P + TG V+AVKKL + Sbjct: 19 SHNMTQFEERHLKFLQQLGKGNFGSV-----EMCRYDPLQDNTGEVVAVKKLQHSTEEHL 73 Query: 116 REWLTEINYLGQLSHPNLVKLIGYCLEDEHR--LLVYEFMQKGSLENHLFR---RGAYFK 170 R++ EI L L H N+VK G C R L+ E++ GSL ++L + R + K Sbjct: 74 RDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIK 133 Query: 171 PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMG 230 L + ++ KG+ +L + + I+RD+ NIL++ + K+ DFGL + P Sbjct: 134 LLQYTSQI------CKGMEYLGTK--RYIHRDLATRNILVENENRVKIGDFGLTKVLPQ- 184 Query: 231 DLSYVSTRVMGT--YGYAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 D Y + G + APE ++ + SDV+SFGV+L E+ + Sbjct: 185 DKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFT 230 >5KMM-A nrPDB Length = 329 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 63/213 (29%), Positives = 96/213 (45%), Gaps = 17/213 (7%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +GEG FG VF + L P + +++AVK L + +++ E L L H + Sbjct: 43 LGEGAFGKVFLA--ECHNLLPEQ--DKMLVAVKALKEASESARQDFQREAELLTMLQHQH 98 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFK-----------PLPWFLRVNVA 181 +V+ G C E L+V+E+M+ G L L G K PL + VA Sbjct: 99 IVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVA 158 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 A G+ +L + ++RD+ N L+ K+ DFG++RD D V R M Sbjct: 159 SQVAAGMVYLAG--LHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTML 216 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 + PE + SDV+SFGV+L EI + Sbjct: 217 PIRWMPPESILYRKFTTESDVWSFGVVLWEIFT 249 >1K9A-A nrPDB Length = 450 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 72/228 (31%), Positives = 111/228 (48%), Gaps = 34/228 (14%) Query: 54 SFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ 113 + ELKL IG+G FG V G G +AVK + + Sbjct: 189 ALNMKELKLL-------QTIGKGEFGDVMLG-----------DYRGNKVAVKCIKNDATA 230 Query: 114 GHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPL 172 + +L E + + QL H NLV+L+G +E++ L +V E+M KGSL ++L RG Sbjct: 231 --QAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGG 288 Query: 173 PWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDL 232 L+ +LD + + +L + ++RD+ A N+L+ D AK+SDFGL ++ Sbjct: 289 DCLLKF--SLDVCEAMEYLEGN--NFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS---- 340 Query: 233 SYVSTRVMGT--YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRA 278 ST+ G + APE + + +SDV+SFG+LL EI S R Sbjct: 341 ---STQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRV 385 >4XUF-A nrPDB Length = 297 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 76/235 (32%), Positives = 110/235 (46%), Gaps = 35/235 (14%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL-TEIN 123 N V+G G FG V ++ + +K G + +AVK L ++ RE L +E+ Sbjct: 9 ENLEFGKVLGSGAFGKV----MNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELK 64 Query: 124 YLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF----------KPL 172 + QL SH N+V L+G C L++E+ G L N+L + F K L Sbjct: 65 MMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRL 124 Query: 173 PWFLRVNV---------ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGL 223 +NV A AKG+ FL ++RD+ A N+L+ K+ DFGL Sbjct: 125 EEEEDLNVLTFEDLLCFAYQVAKGMEFLEFK--SCVHRDLAARNVLVTHGKVVKICDFGL 182 Query: 224 ARDGPMGDLSYVSTRVMGT----YGYAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 ARD M D +YV V G + APE + G +SDV+S+G+LL EI S Sbjct: 183 ARD-IMSDSNYV---VRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFS 233 >1FVR-A nrPDB Length = 327 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 74/223 (33%), Positives = 112/223 (50%), Gaps = 38/223 (17%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG-HREWLTEINYLGQLSH 130 VIGEG FG V K + K G + A+K++ + + HR++ E+ L +L H Sbjct: 32 VIGEGNFGQVLKARI-------KKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGH 84 Query: 131 -PNLVKLIGYCLEDEHRLLVY---EFMQKGSLENHLFRRGAYFKPLPWFLRVN------- 179 PN++ L+G C EHR +Y E+ G+L + L R+ + P F N Sbjct: 85 HPNIINLLGAC---EHRGYLYLAIEYAPHGNLLDFL-RKSRVLETDPAFAIANSTASTLS 140 Query: 180 ------VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 A D A+G+ +L + I+RD+ A NIL+ +Y AK++DFGL+R G Sbjct: 141 SQQLLHFAADVARGMDYLSQK--QFIHRDLAARNILVGENYVAKIADFGLSR----GQEV 194 Query: 234 YVSTRVMGT--YGYAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 YV + MG + A E ++ SDV+S+GVLL EI+S Sbjct: 195 YVK-KTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVS 236 >6GQK-A nrPDB Length = 328 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 85/298 (28%), Positives = 129/298 (43%), Gaps = 43/298 (14%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTE----INYLGQ 127 +G G FG V ++ + K + +AVK L RE L ++YLG Sbjct: 48 TLGAGAFGKV----VEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLG- 102 Query: 128 LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPW--------FLRV- 178 +H N+V L+G C L++ E+ G L N L R+ F P FL + Sbjct: 103 -NHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLE 161 Query: 179 ---NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 + + AKG+AFL S I+RD+ A NILL K+ DFGLARD D +YV Sbjct: 162 HLLSFSYQVAKGMAFLASK--NCIHRDLAARNILLTHGNITKICDFGLARD-IKNDSNYV 218 Query: 236 ST-RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWA 294 + APE + + SDV+S+G+ L E+ S + P Sbjct: 219 DKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMP---------- 268 Query: 295 RPYLTSKRKVLLIVDNRLDT-QYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 + SK ++ R+ + +Y P E M + C +P RPT Q+V+ +++ Sbjct: 269 ---VDSKFYKMIKEGFRMSSPEYAPAE---MYDIMKTCWDADPDKRPTFKQIVQDIEK 320 >2W1I-A nrPDB Length = 326 Score = 85.5 bits (210), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 65/209 (31%), Positives = 104/209 (49%), Gaps = 21/209 (10%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +G+G FG V + P + TG V+AVKKL + R++ EI L L H N Sbjct: 49 LGKGNFGSV-----EMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDN 103 Query: 133 LVKLIGYCLEDEHR--LLVYEFMQKGSLENHLFR---RGAYFKPLPWFLRVNVALDAAKG 187 +VK G C R L+ E++ GSL ++L + R + K L + ++ KG Sbjct: 104 IVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI------CKG 157 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT--YGY 245 + +L + + I+RD+ NIL++ + K+ DFGL + P D Y + G + Sbjct: 158 MEYLGTK--RYIHRDLATRNILVENENRVKIGDFGLTKVLPQ-DKEYYKVKEPGESPIFW 214 Query: 246 AAPEYMSSGHLNARSDVYSFGVLLLEILS 274 APE ++ + SDV+SFGV+L E+ + Sbjct: 215 YAPESLTESKFSVASDVWSFGVVLYELFT 243 >3KRL-A nrPDB Length = 335 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 96/337 (28%), Positives = 144/337 (42%), Gaps = 58/337 (17%) Query: 45 EILSSTPVKSFTF---------NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTK 95 +I+ S S+TF + + N + +G G FG V ++ + K Sbjct: 17 KIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKV----VEATAFGLGK 72 Query: 96 PGTGLVIAVKKLNQEGFQGHREWLTE----INYLGQLSHPNLVKLIGYCLEDEHRLLVYE 151 L +AVK L +E L +++LGQ H N+V L+G C L++ E Sbjct: 73 EDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQ--HENIVNLLGACTHGGPVLVITE 130 Query: 152 FMQKGSLENHLFRR---GAYFKPLPWFLR---------VNVALDAAKGLAFLHSDPVKVI 199 + G L N L R+ G + P ++ + A+G+AFL S I Sbjct: 131 YCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASK--NCI 188 Query: 200 YRDIKASNILLDADYNAKLSDFGLARDGPMGDLSY-VSTRVMGTYGYAAPEYMSSGHLNA 258 +RD+ A N+LL + AK+ DFGLARD M D +Y V + APE + Sbjct: 189 HRDVAARNVLLTNGHVAKIGDFGLARD-IMNDSNYIVKGNARLPVKWMAPESIFDCVYTV 247 Query: 259 RSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY---LTSKRKVLLIVDNRLDTQ 315 +SDV+S+G+LL EI S L N PY L + + L+ D Q Sbjct: 248 QSDVWSYGILLWEIFS----LGLN-------------PYPGILVNSKFYKLVKDGYQMAQ 290 Query: 316 YLPEEAVR-MASVAVQCLSFEPKSRPTMDQVVRALQQ 351 P A + + S+ C + EP RPT Q+ LQ+ Sbjct: 291 --PAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQE 325 >5X02-A nrPDB Length = 347 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 76/235 (32%), Positives = 110/235 (46%), Gaps = 35/235 (14%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL-TEIN 123 N V+G G FG V ++ + +K G + +AVK L ++ RE L +E+ Sbjct: 48 ENLEFGKVLGSGAFGKV----MNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELK 103 Query: 124 YLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF----------KPL 172 + QL SH N+V L+G C L++E+ G L N+L + F K L Sbjct: 104 MMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRL 163 Query: 173 PWFLRVNV---------ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGL 223 +NV A AKG+ FL ++RD+ A N+L+ K+ DFGL Sbjct: 164 EEEEDLNVLTFEDLLCFAYQVAKGMEFLEFK--SCVHRDLAARNVLVTHGKVVKICDFGL 221 Query: 224 ARDGPMGDLSYVSTRVMGT----YGYAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 ARD M D +YV V G + APE + G +SDV+S+G+LL EI S Sbjct: 222 ARD-IMSDSNYV---VRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFS 272 >1BYG-A nrPDB Length = 278 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 68/209 (32%), Positives = 106/209 (50%), Gaps = 27/209 (12%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IG+G FG V G G +AVK + + + +L E + + QL H N Sbjct: 29 IGKGEFGDVMLG-----------DYRGNKVAVKCIKNDATA--QAFLAEASVMTQLRHSN 75 Query: 133 LVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 LV+L+G +E++ L +V E+M KGSL ++L RG L+ +LD + + +L Sbjct: 76 LVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKF--SLDVCEAMEYL 133 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT--YGYAAPE 249 + ++RD+ A N+L+ D AK+SDFGL ++ ST+ G + APE Sbjct: 134 EGN--NFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS-------STQDTGKLPVKWTAPE 184 Query: 250 YMSSGHLNARSDVYSFGVLLLEILSGKRA 278 + + +SDV+SFG+LL EI S R Sbjct: 185 ALREKKFSTKSDVWSFGILLWEIYSFGRV 213 >2BPM-A nrPDB Length = 309 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 68/217 (31%), Positives = 111/217 (51%), Gaps = 20/217 (9%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKK--LNQEGFQGHREWLTEIN 123 NF+ IGEG +G V+K TG V+A+KK L+ E + EI+ Sbjct: 8 NFQKVEKIGEGTYGVVYKA---------RNKLTGEVVALKKIRLDTETEGVPSTAIREIS 58 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 L +L+HPN+VKL+ + LV+EF+ + + F + +P L + Sbjct: 59 LLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKK---FMDASALTGIPLPLIKSYLFQ 115 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 +GLAF HS +V++RD+K N+L++ + KL+DFGLAR + +Y T + T Sbjct: 116 LLQGLAFCHSH--RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY--THEVVTL 171 Query: 244 GYAAPEY-MSSGHLNARSDVYSFGVLLLEILSGKRAL 279 Y APE + + + D++S G + E+++ +RAL Sbjct: 172 WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL 207 >5SYS-A nrPDB Length = 286 Score = 85.1 bits (209), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 79/288 (27%), Positives = 131/288 (45%), Gaps = 43/288 (14%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDEST---LTPTKPGTGLVIAVKKLNQEGFQGHRE 117 ++ + R + +G+G FG + G + +T + KPGT ++ E F Sbjct: 14 EIPRESLRLEVKLGQGCFGECWMGTWNGTTRVAIKTLKPGT--------MSPEAF----- 60 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 L E + +L H LV+L + +E +V E+M KGSL + L + LP Sbjct: 61 -LQEAQVMKKLRHEKLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQL-- 116 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 V++A A G+A++ + ++RD++A+NIL+ + K++DFGLAR + D Y + Sbjct: 117 VDMAAQIASGMAYVER--MNYVHRDLRAANILVGENLVCKVADFGLARL--IEDNEYTAR 172 Query: 238 R-VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 + + APE G +SDV+SFG+LL E+ + R P Sbjct: 173 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRV-----------------P 215 Query: 297 YL-TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMD 343 Y R+VL V+ PE + + QC +P+ RPT + Sbjct: 216 YPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFE 263 >4EQM-A nrPDB Length = 294 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 59/217 (27%), Positives = 106/217 (48%), Gaps = 15/217 (6%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 K+ ++ +G GG V +L E T+ K + + +E + + Sbjct: 7 KIINERYKIVDKLGGGGMSTV---YLAEDTILNIKVAIKAIFIPPREKEETL---KRFER 60 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 E++ QLSH N+V +I ED+ LV E+++ +L ++ G PL +N Sbjct: 61 EVHNSSQLSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHG----PLSVDTAINF 116 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST-RV 239 G+ H+ +++++RDIK NIL+D++ K+ DFG+A+ + + S T V Sbjct: 117 TNQILDGIK--HAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAK--ALSETSLTQTNHV 172 Query: 240 MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 +GT Y +PE + +D+YS G++L E+L G+ Sbjct: 173 LGTVQYFSPEQAKGEATDECTDIYSIGIVLYEMLVGE 209 >5HIE-A nrPDB Length = 302 Score = 84.7 bits (208), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 75/290 (25%), Positives = 137/290 (47%), Gaps = 38/290 (13%) Query: 73 IGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 IG G FG V+KG W + +AVK L + Q + E+ L + H Sbjct: 44 IGSGSFGTVYKGKWHGD-------------VAVKMLTPQQLQAFK---NEVGVLRKTRHV 87 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 N++ +GY + + +V ++ + SL +HL F+ + +++A A+G+ +L Sbjct: 88 NILLFMGYSTKPQ-LAIVTQWCEGSSLYHHLHIIETKFEMIKL---IDIARQTAQGMDYL 143 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM 251 H+ +I+RD+K++NI L D K+ DFGLA S+ ++ G+ + APE + Sbjct: 144 HAK--SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVI 201 Query: 252 SSGHLNA---RSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIV 308 N +SDVY+FG++L E+++G+ N +++ + R YL+ Sbjct: 202 RMQDKNPYSFQSDVYAFGIVLYELMTGQLPYS-NINNRDQIIFMVGRGYLSP-------- 252 Query: 309 DNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGK 358 D P+ R+ + +CL + RP Q++ +++ L +L K Sbjct: 253 DLSKVRSNCPKAMKRLMA---ECLKKKRDERPLFPQILASIELLARSLPK 299 >4QMW-A nrPDB Length = 310 Score = 84.3 bits (207), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 78/276 (28%), Positives = 125/276 (45%), Gaps = 36/276 (13%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN-QEGFQGHREWLTEINYLGQLSHP 131 IG+G FG VFKG +D T V+A+K ++ +E + EI L Q P Sbjct: 37 IGKGSFGEVFKG-IDNRTQK--------VVAIKIIDLEEAEDEIEDIQQEITVLSQCDSP 87 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 + K G L+D ++ E++ GS + L G PL + + KGL +L Sbjct: 88 YVTKYYGSYLKDTKLWIIMEYLGGGSALD-LLEPG----PLDETQIATILREILKGLDYL 142 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM 251 HS+ K I+RDIKA+N+LL KL+DFG+A G + D +GT + APE + Sbjct: 143 HSE--KKIHRDIKAANVLLSEHGEVKLADFGVA--GQLTDTQIKRNTFVGTPFWMAPEVI 198 Query: 252 SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNR 311 ++++D++S G+ +E+ G+ P K L+ P Sbjct: 199 KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNP-------------PT 245 Query: 312 LDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 L+ Y + + CL+ EP RPT ++++ Sbjct: 246 LEGNY----SKPLKEFVEACLNKEPSFRPTAKELLK 277 >4M66-A nrPDB Length = 325 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 77/245 (31%), Positives = 114/245 (46%), Gaps = 42/245 (17%) Query: 73 IGEGGFGCVFKG----WLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQL 128 +G+GGFG VF+ W + +AVK +N + W E+ + L Sbjct: 28 VGKGGFGVVFRAHHRTWNHD-------------VAVKIVNSKKIS----W--EVKAMVNL 68 Query: 129 SHPNLVKLIGYCLEDEH------RLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 + N++ L+G ED + LV FM+ GSL L P PW L + Sbjct: 69 RNENVLLLLGVT-EDLQWDFVSGQALVTRFMENGSLAGLLQPEA----PRPWPLLCRLLQ 123 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLA----RDGPMGDLSYVSTR 238 + G+ +LHS +++RD+K SNILLD + +AKL+DFGL+ S Sbjct: 124 EVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRD 183 Query: 239 VMGTYGYAAPEYMSSGHLNAR--SDVYSFGVLLLEILSGKRA--LDHNRPAKEENLVDWA 294 GT Y PE + +L A SDVYSFG+L+ +L+G+ A +D +E + Sbjct: 184 SGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQS 243 Query: 295 RPYLT 299 RP LT Sbjct: 244 RPPLT 248 >1U54-B nrPDB Length = 291 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 79/297 (26%), Positives = 136/297 (45%), Gaps = 38/297 (12%) Query: 51 PVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE 110 P++S T + ++ R +G+G FG V +G D + G + +AVK L + Sbjct: 7 PLQSLT---CLIGEKDLRLLEKLGDGSFGVVRRGEWDAPS------GKTVSVAVKCLKPD 57 Query: 111 GF---QGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGA 167 + +++ E+N + L H NL++L G L ++ V E GSL + L + Sbjct: 58 VLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKM-VTELAPLGSLLDRLRKHQG 116 Query: 168 YFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG 227 +F L R A+ A+G+ +L S + I+RD+ A N+LL K+ DFGL R Sbjct: 117 HFL-LGTLSRY--AVQVAEGMGYLESK--RFIHRDLAARNLLLATRDLVKIGDFGLMRAL 171 Query: 228 PMGDLSYVSTRVMGT-YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK 286 P D YV + + APE + + + SD + FGV L E+ + + Sbjct: 172 PQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQ--------- 222 Query: 287 EENLVDWARPYL-TSKRKVLLIVDNRLDTQYLPEEAVR-MASVAVQCLSFEPKSRPT 341 P++ + ++L +D + PE+ + + +V VQC + +P+ RPT Sbjct: 223 --------EPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPT 271 >5HI2-A nrPDB Length = 283 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 75/295 (25%), Positives = 138/295 (46%), Gaps = 52/295 (17%) Query: 73 IGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 IG G FG V+KG W + +AVK L + Q + E+ L + H Sbjct: 28 IGSGSFGTVYKGKWHGD-------------VAVKMLTPQQLQAFK---NEVGVLRKTRHV 71 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF--KPLPWFLRVNVALDAAKGLA 189 N++ +GY + + +V ++ + SL +HL F K L +++A A+G+ Sbjct: 72 NILLFMGYSTKPQ-LAIVTQWCEGSSLYHHLHASETKFEMKKL-----IDIARQTARGMD 125 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPE 249 +LH+ +I+RD+K++NI L D K+ DFGLA S+ ++ G+ + APE Sbjct: 126 YLHAK--SIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE 183 Query: 250 YM---SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWA-----RPYLTSK 301 + S + +SDVY+FG++L E+++G+ L ++ + +++ P L+ Sbjct: 184 VIRMQDSNPYSFQSDVYAFGIVLYELMTGQ--LPYSNINNRDQIIEMVGRGSLSPDLSKV 241 Query: 302 RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNL 356 R P+ RM + +CL + RP+ +++ +++L L Sbjct: 242 RS------------NCPK---RMKRLMAECLKKKRDERPSFPRILAEIEELAREL 281 >4HZS-A nrPDB Length = 341 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 76/286 (26%), Positives = 131/286 (45%), Gaps = 35/286 (12%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF---QGHREW 118 + ++ R +G+G FG V +G D + G + +AVK L + + ++ Sbjct: 9 IGEKDLRLLEKLGDGSFGVVRRGEWDAPS------GKTVSVAVKCLKPDVLSQPEAMDDF 62 Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 + E+N + L H NL++L G L ++ V E GSL + L + +F L R Sbjct: 63 IREVNAMHSLDHRNLIRLYGVVLTPPMKM-VTELAPLGSLLDRLRKHQGHFL-LGTLSRY 120 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR 238 A+ A+G+ +L S + I+RD+ A N+LL K+ DFGL R P D YV Sbjct: 121 --AVQVAEGMGYLESK--RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQE 176 Query: 239 VMGT-YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY 297 + + APE + + + SD + FGV L E+ + + P+ Sbjct: 177 HRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQ-----------------EPW 219 Query: 298 L-TSKRKVLLIVDNRLDTQYLPEEAVR-MASVAVQCLSFEPKSRPT 341 + + ++L +D + PE+ + + +V VQC + +P+ RPT Sbjct: 220 IGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPT 265 >4XEY-B nrPDB Length = 408 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 72/281 (25%), Positives = 134/281 (47%), Gaps = 33/281 (11%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +G G +G V++G + +LT +AVK L ++ + E+L E + ++ HPN Sbjct: 133 LGGGQYGEVYEGVWKKYSLT---------VAVKTLKEDTMEV-EEFLKEAAVMKEIKHPN 182 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 LV+L+G C + ++ EFM G+L ++L R + + + + +A + + +L Sbjct: 183 LVQLLGVCTREPPFYIITEFMTYGNLLDYL--RECNRQEVNAVVLLYMATQISSAMEYLE 240 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMS 252 I+RD+ A N L+ ++ K++DFGL+R GD + APE ++ Sbjct: 241 KK--NFIHRDLAARNCLVGENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLA 297 Query: 253 SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRL 312 + +SDV++FGVLL EI + + P +D ++ Y LL D R+ Sbjct: 298 YNKFSIKSDVWAFGVLLWEIATYGMS---PYPG-----IDLSQVY------ELLEKDYRM 343 Query: 313 D-TQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 + + PE+ + C + P RP+ ++ +A + + Sbjct: 344 ERPEGCPEKVYELMRA---CWQWNPSDRPSFAEIHQAFETM 381 >3A4O-X nrPDB Length = 286 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 63/203 (31%), Positives = 103/203 (50%), Gaps = 18/203 (8%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +G G FG V+ G+ + ST +AVK L + G + +L E N + L H Sbjct: 21 LGAGQFGEVWMGYYNNST----------KVAVKTL-KPGTMSVQAFLEEANLMKTLQHDK 69 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 LV+L +E ++ E+M KGSL + L LP ++ + A+G+A++ Sbjct: 70 LVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKL--IDFSAQIAEGMAYIE 127 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR-VMGTYGYAAPEYM 251 I+RD++A+N+L+ K++DFGLAR + D Y + + APE + Sbjct: 128 RK--NYIHRDLRAANVLVSESLMCKIADFGLAR--VIEDNEYTAREGAKFPIKWTAPEAI 183 Query: 252 SSGHLNARSDVYSFGVLLLEILS 274 + G +SDV+SFG+LL EI++ Sbjct: 184 NFGCFTIKSDVWSFGILLYEIVT 206 >4H1J-A nrPDB Length = 293 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 77/295 (26%), Positives = 136/295 (46%), Gaps = 36/295 (12%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLT 120 +A + + ++GEG FG V++G + G + +AVK ++ ++E +++ Sbjct: 21 IAREDVVLNRILGEGFFGEVYEG------VYTNHKGEKINVAVKTCKKDCTLDNKEKFMS 74 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 E + L HP++VKLIG +E+E ++ E G L ++L R K L L Sbjct: 75 EAVIMKNLDHPHIVKLIGI-IEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVL---Y 130 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 +L K +A+L S + ++RDI NIL+ + KL DFGL+R + D Y V Sbjct: 131 SLQICKAMAYLES--INCVHRDIAVRNILVASPECVKLGDFGLSRY--IEDEDYYKASVT 186 Query: 241 GT-YGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYL 298 + +PE ++ SDV+ F V + EILS GK +P+ Sbjct: 187 RLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGK------------------QPFF 228 Query: 299 TSKRKVLLIVDNRLDTQYLPEEA-VRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 + K ++ V + D P+ + ++ +C ++P RP ++V +L + Sbjct: 229 WLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDV 283 >5FM2-A nrPDB Length = 355 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 93/316 (29%), Positives = 139/316 (43%), Gaps = 57/316 (18%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLV-IAVKKLNQEGFQGH-REWLTEI 122 +N +GEG FG V K +T K G +AVK L + R+ L+E Sbjct: 64 KNLVLGKTLGEGEFGKVVK-----ATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEF 118 Query: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR----- 177 N L Q++HP+++KL G C +D LL+ E+ + GSL L K P +L Sbjct: 119 NVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESR---KVGPGYLGSGGSR 175 Query: 178 ------------------VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLS 219 ++ A ++G+ +L +K+++RD+ A NIL+ K+S Sbjct: 176 NSSSLDHPDERALTMGDLISFAWQISQGMQYLAE--MKLVHRDLAARNILVAEGRKMKIS 233 Query: 220 DFGLARDGPMGDLSYVSTRVMG--TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GK 276 DFGL+RD D SYV R G + A E + +SDV+SFGVLL EI++ G Sbjct: 234 DFGLSRDVYEED-SYVK-RSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGG 291 Query: 277 RALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEP 336 P + NL+ T R R D EE R+ +QC EP Sbjct: 292 NPYPGIPPERLFNLLK------TGHRM------ERPDN--CSEEMYRL---MLQCWKQEP 334 Query: 337 KSRPTMDQVVRALQQL 352 RP + + L+++ Sbjct: 335 DKRPVFADISKDLEKM 350 >4RA4-A nrPDB Length = 355 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 67/232 (28%), Positives = 112/232 (48%), Gaps = 25/232 (10%) Query: 54 SFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ 113 S + +KL NF V+G+G FG V + + GT + A+K L ++ Sbjct: 11 SNNLDRVKLTDFNFL--MVLGKGSFGKV---------MLADRKGTEELYAIKILKKDVVI 59 Query: 114 GHREW---LTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYF 169 + + E L L P + + C + RL V E++ G L H+ + G + Sbjct: 60 QDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFK 119 Query: 170 KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPM 229 +P F +++ GL FLH +IYRD+K N++LD++ + K++DFG+ ++ M Sbjct: 120 EPQAVFYAAEISI----GLFFLHKR--GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMM 173 Query: 230 GDLSYVSTRVM-GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 V+TR GT Y APE ++ D +++GVLL E+L+G+ D Sbjct: 174 DG---VTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFD 222 >4KIK-B nrPDB Length = 677 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 68/223 (30%), Positives = 99/223 (44%), Gaps = 41/223 (18%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYLGQLSHP 131 +G GGFG V + W ++ T G IA+K+ QE +RE W EI + +L+HP Sbjct: 27 LGTGGFGNVIR-WHNQET--------GEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHP 77 Query: 132 NLVKL------IGYCLEDEHRLLVYEFMQKGSLENHL--------FRRGAYFKPLPWFLR 177 N+V + ++ LL E+ Q G L +L R GA L Sbjct: 78 NVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLS---- 133 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA---KLSDFGLARDGPMGDLSY 234 D A L +LH + ++I+RD+K NI+L K+ D G A++ G L Sbjct: 134 -----DIASALRYLHEN--RIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLC- 185 Query: 235 VSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKR 277 T +GT Y APE + D +SFG L E ++G R Sbjct: 186 --TSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFR 226 >6NPU-A nrPDB Length = 298 Score = 82.4 bits (202), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 72/281 (25%), Positives = 134/281 (47%), Gaps = 33/281 (11%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +G G +G V++G + +LT +AVK L ++ + E+L E + ++ HPN Sbjct: 34 LGGGQYGEVYEGVWKKYSLT---------VAVKTLKEDTMEV-EEFLKEAAVMKEIKHPN 83 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 LV+L+G C + ++ EFM G+L ++L R + + + + +A + + +L Sbjct: 84 LVQLLGVCTREPPFYIITEFMTYGNLLDYL--RECNRQEVNAVVLLYMATQISSAMEYLE 141 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMS 252 I+RD+ A N L+ ++ K++DFGL+R GD + APE ++ Sbjct: 142 KK--NFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAPESLA 198 Query: 253 SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRL 312 + +SDV++FGVLL EI + + P +D ++ Y LL D R+ Sbjct: 199 YNKFSIKSDVWAFGVLLWEIATYGMS---PYPG-----IDLSQVY------ELLEKDYRM 244 Query: 313 D-TQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 + + PE+ + C + P RP+ ++ +A + + Sbjct: 245 ERPEGCPEKVYELMRA---CWQWNPSDRPSFAEIHQAFETM 282 >2PSQ-A nrPDB Length = 370 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 74/269 (27%), Positives = 122/269 (45%), Gaps = 42/269 (15%) Query: 27 LSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWL 86 LSS + +A + E L P F ++L L +P +GEG FG V Sbjct: 53 LSSTADTPMLAGVSEYE---LPEDPKWEFPRDKLTLG----KP---LGEGCFGQVVMA-- 100 Query: 87 DESTLTPTKPGTGLVIAVKKLNQEGFQGH-REWLTEINYLGQL-SHPNLVKLIGYCLEDE 144 + + KP + +AVK L + + + ++E+ + + H N++ L+G C +D Sbjct: 101 EAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG 160 Query: 145 HRLLVYEFMQKGSLENHLFRR-----------------GAYFKPLPWFLRVNVALDAAKG 187 ++ E+ KG+L +L R FK L V+ A+G Sbjct: 161 PLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDL-----VSCTYQLARG 215 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG--TYGY 245 + +L S K I+RD+ A N+L+ + K++DFGLARD + ++ Y G + Sbjct: 216 MEYLASQ--KCIHRDLAARNVLVTENNVMKIADFGLARD--INNIDYYKKTTNGRLPVKW 271 Query: 246 AAPEYMSSGHLNARSDVYSFGVLLLEILS 274 APE + +SDV+SFGVL+ EI + Sbjct: 272 MAPEALFDRVYTHQSDVWSFGVLMWEIFT 300 >4HVI-A nrPDB Length = 314 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 67/214 (31%), Positives = 106/214 (49%), Gaps = 15/214 (7%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 R+ + S +G+G FG V + P TG ++AVK+L G R++ EI Sbjct: 10 RHLKYISQLGKGNFGSV-----ELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQI 64 Query: 125 LGQLSHPNLVKLIG--YCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 L L +VK G Y + LV E++ G L + L R A L + Sbjct: 65 LKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLL---YSS 121 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 KG+ +L S + ++RD+ A NIL++++ + K++DFGLA+ P+ D Y R G Sbjct: 122 QICKGMEYLGSR--RCVHRDLAARNILVESEAHVKIADFGLAKLLPL-DKDYYVVREPGQ 178 Query: 243 YG--YAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 + APE +S + +SDV+SFGV+L E+ + Sbjct: 179 SPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFT 212 >4AT3-A nrPDB Length = 299 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 61/211 (28%), Positives = 97/211 (45%), Gaps = 15/211 (7%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +GEG FG VF + L P + +++AVK L +++ E L L H + Sbjct: 21 LGEGAFGKVFLA--ECYNLCPEQ--DKILVAVKTLKDASDNARKDFHREAELLTNLQHEH 76 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRG------AYFKP---LPWFLRVNVALD 183 +VK G C+E + ++V+E+M+ G L L G A P L +++A Sbjct: 77 IVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQ 136 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 A G+ +L S ++RD+ N L+ + K+ DFG++RD D V M Sbjct: 137 IAAGMVYLASQ--HFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPI 194 Query: 244 GYAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 + PE + SDV+S GV+L EI + Sbjct: 195 RWMPPESIMYRKFTTESDVWSLGVVLWEIFT 225 >1FOT-A nrPDB Length = 318 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 49/151 (32%), Positives = 85/151 (56%), Gaps = 11/151 (7%) Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 L ++HP ++++ G + + ++ ++++ G L + L + + P+ F V L Sbjct: 60 LSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCL-- 117 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYG 244 L +LHS +IYRD+K NILLD + + K++DFG A+ P D++Y + GT Sbjct: 118 --ALEYLHSK--DIIYRDLKPENILLDKNGHIKITDFGFAKYVP--DVTYT---LCGTPD 168 Query: 245 YAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 Y APE +S+ N D +SFG+L+ E+L+G Sbjct: 169 YIAPEVVSTKPYNKSIDWWSFGILIYEMLAG 199 >3QA8-A nrPDB Length = 676 Score = 81.6 bits (200), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 65/217 (29%), Positives = 103/217 (47%), Gaps = 29/217 (13%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYLGQLSHP 131 +G GGFG V + W+ + T G +A+K+ QE +RE W EI + +L+HP Sbjct: 22 LGTGGFGYVLR-WIHQDT--------GEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHP 72 Query: 132 NLVKL------IGYCLEDEHRLLVYEFMQKGSLENHL--FRRGAYFKPLPWFLRVNVALD 183 N+V + ++ LL E+ + G L +L F K P +R ++ D Sbjct: 73 NVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGP--IRTLLS-D 129 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNA---KLSDFGLARDGPMGDLSYVSTRVM 240 + L +LH + ++I+RD+K NI+L K+ D G A++ G+L T + Sbjct: 130 ISSALRYLHEN--RIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELC---TEFV 184 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKR 277 GT Y APE + D +SFG L E ++G R Sbjct: 185 GTLQYLAPELLEQKKYTVTVDYWSFGTLAFECITGFR 221 >2FO0-A nrPDB Length = 495 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 71/281 (25%), Positives = 134/281 (47%), Gaps = 33/281 (11%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +G G +G V++G + +LT +AVK L ++ + E+L E + ++ HPN Sbjct: 225 LGGGQYGEVYEGVWKKYSLT---------VAVKTLKEDTMEV-EEFLKEAAVMKEIKHPN 274 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 LV+L+G C + ++ EFM G+L ++L R + + + + +A + + +L Sbjct: 275 LVQLLGVCTREPPFYIITEFMTYGNLLDYL--RECNRQEVNAVVLLYMATQISSAMEYLE 332 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMS 252 I+R++ A N L+ ++ K++DFGL+R GD + APE ++ Sbjct: 333 KK--NFIHRNLAARNCLVGENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLA 389 Query: 253 SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRL 312 + +SDV++FGVLL EI + + P +D ++ Y LL D R+ Sbjct: 390 YNKFSIKSDVWAFGVLLWEIATYGMS---PYPG-----IDLSQVY------ELLEKDYRM 435 Query: 313 D-TQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 + + PE+ + C + P RP+ ++ +A + + Sbjct: 436 ERPEGCPEKVYELMRA---CWQWNPSDRPSFAEIHQAFETM 473 >3GQL-A nrPDB Length = 326 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 68/217 (31%), Positives = 105/217 (48%), Gaps = 20/217 (9%) Query: 73 IGEGGFGCVFKGWLDEST-LTPTKPGTGLVIAVKKLNQEGFQGH-REWLTEINYLGQL-S 129 +GEG FG V L E+ L KP +AVK L + + + ++E+ + + Sbjct: 36 LGEGAFGQVV---LAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 92 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGA-----YFKP-------LPWFLR 177 H N++ L+G C +D ++ E+ KG+L +L R + P L Sbjct: 93 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 152 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 V+ A A+G+ +L S K I+RD+ A N+L+ D K++DFGLARD D +T Sbjct: 153 VSCAYQVARGMEYLASK--KCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTT 210 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 + APE + +SDV+SFGVLL EI + Sbjct: 211 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT 247 >3CJF-A nrPDB Length = 309 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 90/300 (30%), Positives = 124/300 (41%), Gaps = 50/300 (16%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG-HREWLTEINYLGQLSHP 131 +G G FG V ++ K T +AVK L + HR ++E+ L + H Sbjct: 35 LGRGAFGQV----IEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHH 90 Query: 132 -NLVKLIGYCLEDEHRLLVY-EFMQKGSLENHLFRRGAYFKPLPWFLR--------VNVA 181 N+V L+G C + L+V EF + G+L +L + F P + + + Sbjct: 91 LNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYS 150 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV---STR 238 AKG+ FL S K I+RD+ A NILL K+ DFGLARD D YV R Sbjct: 151 FQVAKGMEFLASR--KCIHRDLAARNILLSEKNVVKICDFGLARD-IYKDPDYVRKGDAR 207 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 + + APE + +SDV+SFGVLL EI S A PY Sbjct: 208 L--PLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLG-----------------ASPYP 248 Query: 299 TSK------RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 K R++ R PE M + C EP RPT ++V L L Sbjct: 249 GVKIDEEFCRRLKEGTRMRAPDYTTPE----MYQTMLDCWHGEPSQRPTFSELVEHLGNL 304 >3BBT-B nrPDB Length = 328 Score = 81.3 bits (199), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 102/204 (50%), Gaps = 12/204 (5%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE-GFQGHREWLTEINYLGQLSH 130 V+G G FG V+KG P + +A+K LN+ G + + E++ E + + H Sbjct: 22 VLGSGAFGTVYKG-----IWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH 76 Query: 131 PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAF 190 P+LV+L+G CL +L V + M G L ++ L +N + AKG+ + Sbjct: 77 PHLVRLLGVCLSPTIQL-VTQLMPHGCLLEYVHEHKDNIGSQ---LLLNWCVQIAKGMMY 132 Query: 191 LHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEY 250 L ++++RD+ A N+L+ + + K++DFGLAR + Y + + A E Sbjct: 133 LEER--RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALEC 190 Query: 251 MSSGHLNARSDVYSFGVLLLEILS 274 + +SDV+S+GV + E+++ Sbjct: 191 IHYRKFTHQSDVWSYGVTIWELMT 214 >5A46-A nrPDB Length = 386 Score = 81.3 bits (199), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 68/217 (31%), Positives = 105/217 (48%), Gaps = 20/217 (9%) Query: 73 IGEGGFGCVFKGWLDEST-LTPTKPGTGLVIAVKKLNQEGFQGH-REWLTEINYLGQL-S 129 +GEG FG V L E+ L KP +AVK L + + + ++E+ + + Sbjct: 48 LGEGCFGQVV---LAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 104 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGA-----YFKP-------LPWFLR 177 H N++ L+G C +D ++ E+ KG+L +L R + P L Sbjct: 105 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 164 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 V+ A A+G+ +L S K I+RD+ A N+L+ D K++DFGLARD D +T Sbjct: 165 VSCAYQVARGMEYLASK--KCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTT 222 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 + APE + +SDV+SFGVLL EI + Sbjct: 223 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT 259 >1U5R-A nrPDB Length = 348 Score = 80.9 bits (198), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 67/213 (31%), Positives = 99/213 (46%), Gaps = 27/213 (12%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW---LTEINYLGQLS 129 IG G FG V+ V+A+KK++ G Q + +W + E+ +L +L Sbjct: 62 IGHGSFGAVYFA---------RDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLR 112 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 HPN ++ G L + LV E+ GS + L + KPL V A +GLA Sbjct: 113 HPNTIQYRGCYLREHTAWLVMEYCL-GSASDLL---EVHKKPLQEVEIAAVTHGALQGLA 168 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPE 249 +LHS +I+RD+KA NILL KL DFG A + + +GT + APE Sbjct: 169 YLHSH--NMIHRDVKAGNILLSEPGLVKLGDFGSA------SIMAPANSFVGTPYWMAPE 220 Query: 250 Y---MSSGHLNARSDVYSFGVLLLEILSGKRAL 279 M G + + DV+S G+ +E+ K L Sbjct: 221 VILAMDEGQYDGKVDVWSLGITCIELAERKPPL 253 >2GCD-A nrPDB Length = 309 Score = 80.9 bits (198), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 67/213 (31%), Positives = 99/213 (46%), Gaps = 27/213 (12%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW---LTEINYLGQLS 129 IG G FG V+ V+A+KK++ G Q + +W + E+ +L +L Sbjct: 23 IGHGSFGAVYFA---------RDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLR 73 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 HPN ++ G L + LV E+ GS + L + KPL V A +GLA Sbjct: 74 HPNTIQYRGCYLREHTAWLVMEYCL-GSASDLL---EVHKKPLQEVEIAAVTHGALQGLA 129 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPE 249 +LHS +I+RD+KA NILL KL DFG A + + +GT + APE Sbjct: 130 YLHSH--NMIHRDVKAGNILLSEPGLVKLGDFGSA------SIMAPANSFVGTPYWMAPE 181 Query: 250 Y---MSSGHLNARSDVYSFGVLLLEILSGKRAL 279 M G + + DV+S G+ +E+ K L Sbjct: 182 VILAMDEGQYDGKVDVWSLGITCIELAERKPPL 214 >4L42-A nrPDB Length = 346 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 78/258 (30%), Positives = 120/258 (46%), Gaps = 30/258 (11%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF------QG 114 K+ F V+G+GG+G VF+ T TG + A+K L + Sbjct: 14 KIRPECFELLRVLGKGGYGKVFQ------VRKVTGANTGKIFAMKVLKKAMIVRNAKDTA 67 Query: 115 HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLP 173 H + E N L ++ HP +V LI Y + +L L+ E++ G L L R G + + Sbjct: 68 HTK--AERNILEEVKHPFIVDLI-YAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTA 124 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 F +++ L LH +IYRD+K NI+L+ + KL+DFGL ++ + D Sbjct: 125 CFYLAEISM----ALGHLHQK--GIIYRDLKPENIMLNHQGHVKLTDFGLCKES-IHD-G 176 Query: 234 YVSTRVMGTYGYAAPEY-MSSGHLNARSDVYSFGVLLLEILSGKRALD-HNRPAKEENLV 291 V+ GT Y APE M SGH N D +S G L+ ++L+G NR + ++ Sbjct: 177 TVTHTFCGTIEYMAPEILMRSGH-NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKIL 235 Query: 292 DWAR---PYLTSKRKVLL 306 PYLT + + LL Sbjct: 236 KCKLNLPPYLTQEARDLL 253 >3AOX-A nrPDB Length = 344 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 66/209 (31%), Positives = 99/209 (47%), Gaps = 13/209 (6%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE-GFQGHREWLTEINYLGQLSHP 131 +G G FG V++G + + P P + L +AVK L + Q ++L E + + +H Sbjct: 55 LGHGAFGEVYEG---QVSGMPNDP-SPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQ 110 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFR---RGAYFKPLPWFLRVNVALDAAKGL 188 N+V+ IG L+ R ++ E M G L++ L R + L ++VA D A G Sbjct: 111 NIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGC 170 Query: 189 AFLHSDPVKVIYRDIKASNILLDAD---YNAKLSDFGLARDGPMGDLSYVSTRVMGTYGY 245 +L + I+RDI A N LL AK+ DFG+ARD M + Sbjct: 171 QYLEEN--HFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKW 228 Query: 246 AAPEYMSSGHLNARSDVYSFGVLLLEILS 274 PE G +++D +SFGVLL EI S Sbjct: 229 MPPEAFMEGIFTSKTDTWSFGVLLWEIFS 257 >5F9E-A nrPDB Length = 353 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 99/222 (44%), Gaps = 21/222 (9%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW 118 ++KL +F ++G+G FG VF + T A+K L ++ + Sbjct: 13 QIKLKIEDFELHKMLGKGSFGKVFLAEFKK---------TNQFFAIKALKKDVVLMDDDV 63 Query: 119 ---LTEINYLG-QLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPW 174 + E L HP L + E+ V E++ G L H+ + Sbjct: 64 ECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRAT 123 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSY 234 F + L GL FLHS ++YRD+K NILLD D + K++DFG+ ++ +GD Sbjct: 124 FYAAEIIL----GLQFLHSK--GIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAK- 176 Query: 235 VSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 + GT Y APE + N D +SFGVLL E+L G+ Sbjct: 177 -TNEFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQ 217 >3TT0-A nrPDB Length = 382 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 68/217 (31%), Positives = 105/217 (48%), Gaps = 20/217 (9%) Query: 73 IGEGGFGCVFKGWLDEST-LTPTKPGTGLVIAVKKLNQEGFQGH-REWLTEINYLGQLS- 129 +GEG FG V L E+ L KP +AVK L + + + ++E+ + + Sbjct: 77 LGEGAFGQVV---LAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 133 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR---GAYFKPLPWFLR--------- 177 H N++ L+G C +D ++ E+ KG+L +L R G + P Sbjct: 134 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDL 193 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 V+ A A+G+ +L S K I+RD+ A N+L+ D K++DFGLARD D +T Sbjct: 194 VSCAYQVARGMEYLASK--KCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTT 251 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 + APE + +SDV+SFGVLL EI + Sbjct: 252 NGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT 288 >5EG3-A nrPDB Length = 334 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 61/216 (28%), Positives = 103/216 (47%), Gaps = 18/216 (8%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-REWLTEINYLGQL-SH 130 +GEG FG V + + KP + +AVK L + + + ++E+ + + H Sbjct: 43 LGEGAFGQVVMA--EAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 100 Query: 131 PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR---GAYFKP---------LPWFLRV 178 N++ L+G C +D ++ + KG+L +L R G P + + V Sbjct: 101 KNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRVPEEQMTFKDLV 160 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR 238 + A+G+ +L S K I+RD+ A N+L+ + K++DFGLARD D +T Sbjct: 161 SCTYQLARGMEYLASQ--KCIHRDLAARNVLVTENNVMKIADFGLARDINNIDFFKETTN 218 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 + APE + +SDV+SFGVL+ EI + Sbjct: 219 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFT 254 >5U6B-A nrPDB Length = 307 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 61/211 (28%), Positives = 104/211 (49%), Gaps = 21/211 (9%) Query: 73 IGEGGFGCVFKGWL--DESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSH 130 +GEG FG V +G L D+S L + I + ++ +L+E + + H Sbjct: 31 LGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELED-------FLSEAVCMKEFDH 83 Query: 131 PNLVKLIGYCLEDEHR------LLVYEFMQKGSLENHLF--RRGAYFKPLPWFLRVNVAL 182 PN+++LIG C + R +++ FM+ G L + L R G LP + V Sbjct: 84 PNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMA 143 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 D A G+ +L + + I+RD+ A N +L+ + + ++DFGL++ GD Y R+ Sbjct: 144 DIASGMEYLSTK--RFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDY-YRQGRIAKM 200 Query: 243 -YGYAAPEYMSSGHLNARSDVYSFGVLLLEI 272 + A E ++ ++SDV+SFGV + EI Sbjct: 201 PVKWIAIESLADRVYTSKSDVWSFGVTMWEI 231 >4APC-A nrPDB Length = 350 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 60/212 (28%), Positives = 103/212 (48%), Gaps = 21/212 (9%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IGEG FG K L +ST + G VI +++ + E E+ L + HPN Sbjct: 32 IGEGSFG---KAILVKST----EDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPN 84 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHL-FRRGAYFKP---LPWFLRVNVALDAAKGL 188 +V+ E+ +V ++ + G L + ++G F+ L WF+++ +AL Sbjct: 85 IVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALK----- 139 Query: 189 AFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAP 248 H K+++RDIK+ NI L D +L DFG+AR + ++ +GT Y +P Sbjct: 140 ---HVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIAR--VLNSTVELARACIGTPYYLSP 194 Query: 249 EYMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 E + N +SD+++ G +L E+ + K A + Sbjct: 195 EICENKPYNNKSDIWALGCVLYELCTLKHAFE 226 >5KKR-C nrPDB Length = 395 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 65/217 (29%), Positives = 110/217 (50%), Gaps = 19/217 (8%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWL 119 +L +F S +G G G VFK KP +GLV+A K ++ E R + + Sbjct: 64 ELKDDDFEKISELGAGNGGVVFK--------VSHKP-SGLVMARKLIHLEIKPAIRNQII 114 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 E+ L + + P +V G D + E M GSL+ L + G +P + Sbjct: 115 RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR----IPEQILGK 170 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 V++ KGL +L + K+++RD+K SNIL+++ KL DFG++ G + D ++ Sbjct: 171 VSIAVIKGLTYLR-EKHKIMHRDVKPSNILVNSRGEIKLCDFGVS--GQLID--SMANSF 225 Query: 240 MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 +GT Y +PE + H + +SD++S G+ L+E+ G+ Sbjct: 226 VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 262 >3G0E-A nrPDB Length = 336 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 83/297 (27%), Positives = 125/297 (42%), Gaps = 41/297 (13%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTE----INYLGQL 128 +G G FG V ++ + K + +AVK L RE L ++YLG Sbjct: 54 LGAGAFGKV----VEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG-- 107 Query: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF---KPLPWFLRV------- 178 +H N+V L+G C L++ E+ G L N L R+ F K P + Sbjct: 108 NHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDL 167 Query: 179 ----NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSY 234 + + AKG+AFL S I+RD+ A NILL K+ DFGLARD Sbjct: 168 EDLLSFSYQVAKGMAFLASK--NCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYV 225 Query: 235 VSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWA 294 V + APE + + SDV+S+G+ L E+ S + P VD + Sbjct: 226 VKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMP------VD-S 278 Query: 295 RPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 + Y K + L ++ P E M + C +P RPT Q+V+ +++ Sbjct: 279 KFYKMIKEGFRM-----LSPEHAPAE---MYDIMKTCWDADPLKRPTFKQIVQLIEK 327 >4RLP-A nrPDB Length = 288 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 78/258 (30%), Positives = 120/258 (46%), Gaps = 30/258 (11%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF------QG 114 K+ F V+G+GG+G VF+ T TG + A+K L + Sbjct: 1 KIRPECFELLRVLGKGGYGKVFQ------VRKVTGANTGKIFAMKVLKKAMIVRNAKDTA 54 Query: 115 HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLP 173 H + E N L ++ HP +V LI Y + +L L+ E++ G L L R G + + Sbjct: 55 HTK--AERNILEEVKHPFIVDLI-YAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTA 111 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 F +++ L LH +IYRD+K NI+L+ + KL+DFGL ++ + D Sbjct: 112 CFYLAEISM----ALGHLHQK--GIIYRDLKPENIMLNHQGHVKLTDFGLCKES-IHD-G 163 Query: 234 YVSTRVMGTYGYAAPEY-MSSGHLNARSDVYSFGVLLLEILSGKRALD-HNRPAKEENLV 291 V+ GT Y APE M SGH N D +S G L+ ++L+G NR + ++ Sbjct: 164 TVTHTFCGTIEYMAPEILMRSGH-NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKIL 222 Query: 292 DWAR---PYLTSKRKVLL 306 PYLT + + LL Sbjct: 223 KCKLNLPPYLTQEARDLL 240 >3EQC-A nrPDB Length = 360 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 65/217 (29%), Positives = 110/217 (50%), Gaps = 19/217 (8%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWL 119 +L +F S +G G G VFK KP +GLV+A K ++ E R + + Sbjct: 29 ELKDDDFEKISELGAGNGGVVFK--------VSHKP-SGLVMARKLIHLEIKPAIRNQII 79 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 E+ L + + P +V G D + E M GSL+ L + G +P + Sbjct: 80 RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR----IPEQILGK 135 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 V++ KGL +L + K+++RD+K SNIL+++ KL DFG++ G + D ++ Sbjct: 136 VSIAVIKGLTYLR-EKHKIMHRDVKPSNILVNSRGEIKLCDFGVS--GQLID--SMANSF 190 Query: 240 MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 +GT Y +PE + H + +SD++S G+ L+E+ G+ Sbjct: 191 VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 227 >4AN9-A nrPDB Length = 301 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 65/217 (29%), Positives = 110/217 (50%), Gaps = 19/217 (8%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWL 119 +L +F S +G G G VFK KP +GLV+A K ++ E R + + Sbjct: 5 ELKDDDFEKISELGAGNGGVVFK--------VSHKP-SGLVMARKLIHLEIKPAIRNQII 55 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 E+ L + + P +V G D + E M GSL+ L + G +P + Sbjct: 56 RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR----IPEQILGK 111 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 V++ KGL +L + K+++RD+K SNIL+++ KL DFG++ G + D ++ Sbjct: 112 VSIAVIKGLTYLR-EKHKIMHRDVKPSNILVNSRGEIKLCDFGVS--GQLID--EMANEF 166 Query: 240 MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 +GT Y +PE + H + +SD++S G+ L+E+ G+ Sbjct: 167 VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGR 203 >2DQ7-X nrPDB Length = 283 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 76/276 (27%), Positives = 126/276 (45%), Gaps = 43/276 (15%) Query: 73 IGEGGFGCVFKGWLDEST---LTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLS 129 +G G FG V+ G + +T + KPGT ++ E F L E + +L Sbjct: 17 LGNGQFGEVWMGTWNGNTKVAIKTLKPGT--------MSPESF------LEEAQIMKKLK 62 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 H LV+L + +E +V E+M KGSL + L LP V++A A G+A Sbjct: 63 HDKLVQLYA-VVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNL--VDMAAQVAAGMA 119 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR-VMGTYGYAAP 248 ++ + I+RD++++NIL+ K++DFGLAR + D Y + + + AP Sbjct: 120 YIER--MNYIHRDLRSANILVGNGLICKIADFGLAR--LIEDNEYTARQGAKFPIKWTAP 175 Query: 249 EYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL-TSKRKVLLI 307 E G +SDV+SFG+LL E+++ R PY + R+VL Sbjct: 176 EAALYGRFTIKSDVWSFGILLTELVTKGRV-----------------PYPGMNNREVLEQ 218 Query: 308 VDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMD 343 V+ + + + + + C +P+ RPT + Sbjct: 219 VERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFE 254 >6GU6-A nrPDB Length = 302 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 69/216 (31%), Positives = 105/216 (48%), Gaps = 27/216 (12%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL----NQEGFQGHREWLTEINYLGQL 128 IGEG +G V+KG TG V+A+KK+ +EG + EI+ L +L Sbjct: 15 IGEGTYGVVYKG---------RHKTTGQVVAMKKIRLESEEEGVPSTA--IREISLLKEL 63 Query: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHL--FRRGAYFKPLPWFLRVNVALDAAK 186 HPN+V L ++D L++EF+ L+ +L G Y L + + Sbjct: 64 RHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDS---SLVKSYLYQILQ 119 Query: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYA 246 G+ F HS +V++RD+K N+L+D KL+DFGLAR G V T + T Y Sbjct: 120 GIVFCHSR--RVLHRDLKPQNLLIDDKGTIKLADFGLAR--AFGIPIRVYTHEVVTLWYR 175 Query: 247 APEY-MSSGHLNARSDVYSFGVLLLEILSGKRALDH 281 +PE + S + D++S G + E L+ K+ L H Sbjct: 176 SPEVLLGSARYSTPVDIWSIGTIFAE-LATKKPLFH 210 >2XIK-A nrPDB Length = 294 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 70/276 (25%), Positives = 124/276 (44%), Gaps = 36/276 (13%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN-QEGFQGHREWLTEINYLGQLSHP 131 IG+G FG V+KG +D T V+A+K ++ +E + EI L Q P Sbjct: 27 IGKGSFGEVYKG-IDNHTKE--------VVAIKIIDLEEAEDEIEDIQQEITVLSQCDSP 77 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 + + G L+ ++ E++ GS + L + G PL + + KGL +L Sbjct: 78 YITRYFGSYLKSTKLWIIMEYLGGGSALD-LLKPG----PLEETYIATILREILKGLDYL 132 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM 251 HS+ + I+RDIKA+N+LL + KL+DFG+A G + D +GT + APE + Sbjct: 133 HSE--RKIHRDIKAANVLLSEQGDVKLADFGVA--GQLTDTQIKRNTFVGTPFWMAPEVI 188 Query: 252 SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNR 311 + ++D++S G+ +E+ G+ P +VL ++ Sbjct: 189 KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPM-----------------RVLFLIPKN 231 Query: 312 LDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 + + CL+ +P+ RPT ++++ Sbjct: 232 SPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLK 267 >4TNB-A nrPDB Length = 590 Score = 78.6 bits (192), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 73/226 (32%), Positives = 107/226 (47%), Gaps = 28/226 (12%) Query: 59 ELKLATRN-FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ---G 114 E + T+N FR V+G+GGFG V + TG + A K+L ++ + G Sbjct: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVR---------ATGKMYACKRLEKKRIKKRKG 227 Query: 115 HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLP 173 L E L +++ +V L Y E + L LV M G L+ H++ G P Sbjct: 228 ESMALNEKQILEKVNSQFVVNL-AYAYETKDALCLVLTIMNGGDLKFHIYNMGN-----P 281 Query: 174 WFLRVNVALDAAK---GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMG 230 F AA+ GL LH + +YRD+K NILLD + ++SD GLA P G Sbjct: 282 GFEEERALFYAAEILCGLEDLHHE--NTVYRDLKPENILLDDYGHIRISDLGLAVKIPEG 339 Query: 231 DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 DL + RV GT GY APE +++ D + G L+ E++ G+ Sbjct: 340 DL--IRGRV-GTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQ 382 >4FL3-A nrPDB Length = 635 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 102/208 (49%), Gaps = 17/208 (8%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLS 129 D +G G FG V KG+ + + I + N + E L E N + QL Sbjct: 374 DKELGSGNFGTVKKGYYQ---MKKVVKTVAVKILKNEANDPALKD--ELLAEANVMQQLD 428 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFR-RGAYFKPLPWFLRVNVALDAAKGL 188 +P +V++IG C E E +LV E + G L +L + R K + + + + G+ Sbjct: 429 NPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNI-----IELVHQVSMGM 482 Query: 189 AFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY--GYA 246 +L ++RD+ A N+LL + AK+SDFGL++ D +Y + G + + Sbjct: 483 KYLEES--NFVHRDLAARNVLLVTQHYAKISDFGLSK-ALRADENYYKAQTHGKWPVKWY 539 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILS 274 APE ++ +++SDV+SFGVL+ E S Sbjct: 540 APECINYYKFSSKSDVWSFGVLMWEAFS 567 >5AR8-A nrPDB Length = 326 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 48/154 (31%), Positives = 82/154 (53%), Gaps = 7/154 (4%) Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 ++ ++G C E E +V E+M GSL N L R + + W LR + + A G+ +LH Sbjct: 94 ILPILGICNEPEFLGIVTEYMPNGSL-NELLHRKTEYPDVAWPLRFRILHEIALGVNYLH 152 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM---GTYGYAAPE 249 + +++ D+K NILLD +++ K++DFGL++ M S++ GT Y PE Sbjct: 153 NMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPE 212 Query: 250 YMSSGH---LNARSDVYSFGVLLLEILSGKRALD 280 G + + D+YS+ V+ E+LS K+ + Sbjct: 213 NYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFE 246 >3PFQ-A nrPDB Length = 674 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 63/227 (27%), Positives = 108/227 (47%), Gaps = 23/227 (10%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 + +KL NF V+G+G FG V + + GT + AVK L ++ + Sbjct: 336 DRMKLTDFNFL--MVLGKGSFGKV---------MLSERKGTDELYAVKILKKDVVIQDDD 384 Query: 118 ---WLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLP 173 + E L P + + C + RL V E++ G L H+ + G + +P Sbjct: 385 VECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHA 444 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 F +A+ GL FL S +IYRD+K N++LD++ + K++DFG+ ++ ++ Sbjct: 445 VFYAAEIAI----GLFFLQSK--GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT 498 Query: 234 YVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 + GT Y APE ++ D ++FGVLL E+L+G+ + Sbjct: 499 --TKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFE 543 >2XYN-A nrPDB Length = 292 Score = 77.8 bits (190), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 58/200 (29%), Positives = 102/200 (51%), Gaps = 15/200 (7%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +G G +G V+ G + +LT +AVK L ++ + E+L E + ++ HPN Sbjct: 40 LGGGQYGEVYVGVWKKYSLT---------VAVKTLKEDTMEV-EEFLKEAAVMKEIKHPN 89 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 LV+L+G C + +V E+M G+L ++L R + + + + +A + + +L Sbjct: 90 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYL--RECNREEVTAVVLLYMATQISSAMEYLE 147 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMS 252 I+RD+ A N L+ ++ K++DFGL+R GD + APE ++ Sbjct: 148 KK--NFIHRDLAARNCLVGENHVVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLA 204 Query: 253 SGHLNARSDVYSFGVLLLEI 272 + +SDV++FGVLL EI Sbjct: 205 YNTFSIKSDVWAFGVLLWEI 224 >6DBN-A nrPDB Length = 316 Score = 77.8 bits (190), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 67/208 (32%), Positives = 100/208 (48%), Gaps = 18/208 (8%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT-EINYLGQLSHP 131 +GEG FG V + P TG +AVK L E H L EI L L H Sbjct: 43 LGEGHFGKV-----ELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHE 97 Query: 132 NLVKLIGYCLEDEHR--LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 N+VK G C ED L+ EF+ GSL+ +L + + ++ A+ KG+ Sbjct: 98 NIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNK---NKINLKQQLKYAVQICKGMD 154 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST---RVMGTYGYA 246 +L S + ++RD+ A N+L+++++ K+ DFGL + D Y + R + Y Sbjct: 155 YLGSR--QYVHRDLAARNVLVESEHQVKIGDFGLTK-AIETDKEYYTVKDDRDSPVFWY- 210 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILS 274 APE + SDV+SFGV L E+L+ Sbjct: 211 APECLMQSKFYIASDVWSFGVTLHELLT 238 >5C26-A nrPDB Length = 299 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 102/208 (49%), Gaps = 17/208 (8%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLS 129 D +G G FG V KG+ + + I + N + E L E N + QL Sbjct: 32 DKELGSGNFGTVKKGYY---QMKKVVKTVAVKILKNEANDPALKD--ELLAEANVMQQLD 86 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFR-RGAYFKPLPWFLRVNVALDAAKGL 188 +P +V++IG C E E +LV E + G L +L + R K + + + + G+ Sbjct: 87 NPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDKNI-----IELVHQVSMGM 140 Query: 189 AFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY--GYA 246 +L ++RD+ A N+LL + AK+SDFGL++ D +Y + G + + Sbjct: 141 KYLEES--NFVHRDLAARNVLLVTQHYAKISDFGLSK-ALRADENYYKAQTHGKWPVKWY 197 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILS 274 APE ++ +++SDV+SFGVL+ E S Sbjct: 198 APECINYYKFSSKSDVWSFGVLMWEAFS 225 >2I0E-A nrPDB Length = 353 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 63/227 (27%), Positives = 108/227 (47%), Gaps = 23/227 (10%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 + +KL NF V+G+G FG V + + GT + AVK L ++ + Sbjct: 15 DRMKLTDFNFL--MVLGKGSFGKV---------MLSERKGTDELYAVKILKKDVVIQDDD 63 Query: 118 ---WLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLP 173 + E L P + + C + RL V E++ G L H+ + G + +P Sbjct: 64 VECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHA 123 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 F +A+ GL FL S +IYRD+K N++LD++ + K++DFG+ ++ ++ Sbjct: 124 VFYAAEIAI----GLFFLQSK--GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT 177 Query: 234 YVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 + GT Y APE ++ D ++FGVLL E+L+G+ + Sbjct: 178 --TKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFE 222 >3NIZ-A nrPDB Length = 311 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 64/213 (30%), Positives = 104/213 (48%), Gaps = 33/213 (15%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL----NQEGFQGHREWLTEINYLGQL 128 +GEG +G V+K K G ++A+K++ EG + EI+ L +L Sbjct: 29 VGEGTYGVVYKA----------KDSQGRIVALKRIRLDAEDEGIPSTA--IREISLLKEL 76 Query: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSL----ENHLFRRGAYFKPLPWFLRVNVALDA 184 HPN+V LI + LV+EFM+K EN + + K + L Sbjct: 77 HHPNIVSLIDVIHSERCLTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQL-------- 128 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYG 244 +G+A H ++++RD+K N+L+++D KL+DFGLAR + SY T + T Sbjct: 129 LRGVAHCHQH--RILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSY--THEVVTLW 184 Query: 245 YAAPEY-MSSGHLNARSDVYSFGVLLLEILSGK 276 Y AP+ M S + D++S G + E+++GK Sbjct: 185 YRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGK 217 >3PP0-A nrPDB Length = 338 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 64/232 (27%), Positives = 114/232 (49%), Gaps = 22/232 (9%) Query: 62 LATRNFRPDSVIGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQE-GFQGHREWL 119 L R V+G G FG V+KG W+ P + +A+K L + + ++E L Sbjct: 14 LKETELRKVKVLGSGAFGTVYKGIWI------PDGENVKIPVAIKVLRENTSPKANKEIL 67 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFR---RGAYFKPLPWFL 176 E + + P + +L+G CL +L V + M G L +H+ R L W + Sbjct: 68 DEAYVMAGVGSPYVSRLLGICLTSTVQL-VTQLMPYGCLLDHVRENRGRLGSQDLLNWCM 126 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 ++ AKG+++L V++++RD+ A N+L+ + + K++DFGLAR + + Y + Sbjct: 127 QI------AKGMSYLED--VRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHA 178 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKE 287 + A E + +SDV+S+GV + E+++ G + D PA+E Sbjct: 179 DGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYD-GIPARE 229 >4FZF-B nrPDB Length = 283 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 63/205 (30%), Positives = 102/205 (49%), Gaps = 19/205 (9%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN-QEGFQGHREWLTEINYLGQLSHP 131 IG+G FG VFKG +D T V+A+K ++ +E + EI L Q Sbjct: 16 IGKGSFGEVFKG-IDNRTQQ--------VVAIKIIDLEEAEDEIEDIQQEITVLSQCDSS 66 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 + K G L+ ++ E++ GS + L R G P F + + KGL +L Sbjct: 67 YVTKYYGSYLKGSKLWIIMEYLGGGSALD-LLRAG----PFDEFQIATMLKEILKGLDYL 121 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM 251 HS+ K I+RDIKA+N+LL + KL+ FG+A G + D +GT + APE + Sbjct: 122 HSE--KKIHRDIKAANVLLSEQGDVKLAAFGVA--GQLTDTQIKRNTFVGTPFWMAPEVI 177 Query: 252 SSGHLNARSDVYSFGVLLLEILSGK 276 ++++D++S G+ +E+ G+ Sbjct: 178 QQSAYDSKADIWSLGITAIELAKGE 202 >1LUF-A nrPDB Length = 343 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 76/303 (25%), Positives = 125/303 (41%), Gaps = 43/303 (14%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWLTEINYLGQLSHP 131 IGEG FG VF+ L P +P T ++AVK L +E + ++ E + + +P Sbjct: 55 IGEGAFGRVFQA--RAPGLLPYEPFT--MVAVKMLKEEASADMQADFQREAALMAEFDNP 110 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF--------------------KP 171 N+VKL+G C + L++E+M G L L + P Sbjct: 111 NIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPP 170 Query: 172 LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGD 231 L ++ +A A G+A+L K ++RD+ N L+ + K++DFGL+R+ D Sbjct: 171 LSCAEQLCIARQVAAGMAYLSER--KFVHRDLATRNCLVGENMVVKIADFGLSRNIYSAD 228 Query: 232 LSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 + PE + SDV+++GV+L EI S L E ++ Sbjct: 229 YYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFS--YGLQPYYGMAHEEVI 286 Query: 292 DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 Y +L +N P E + + C S P RP+ + R LQ+ Sbjct: 287 -----YYVRDGNILACPEN------CPLELYNLMRL---CWSKLPADRPSFCSIHRILQR 332 Query: 352 LQD 354 + + Sbjct: 333 MCE 335 >2WQN-A nrPDB Length = 310 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 63/214 (29%), Positives = 102/214 (47%), Gaps = 24/214 (11%) Query: 66 NFRPDSVIGEGGFGCVFKG--WLDESTLTPTKPGTGLVIAVKKL---NQEGFQGHREWLT 120 NFR + IG G F V++ LD G+ +A+KK+ + + + + Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLD-----------GVPVALKKVQIFDLMDAKARADCIK 81 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHL--FRRGAYFKPLPWFLRV 178 EI+ L QL+HPN++K +ED +V E G L + F++ P + Sbjct: 82 EIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKY 141 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR 238 V L +A L +HS +V++RDIK +N+ + A KL D GL R + + Sbjct: 142 FVQLCSA--LEHMHSR--RVMHRDIKPANVFITATGVVKLGDLGLGRF--FSSKTTAAHS 195 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEI 272 ++GT Y +PE + N +SD++S G LL E+ Sbjct: 196 LVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEM 229 >4Y93-A nrPDB Length = 446 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 59/204 (28%), Positives = 99/204 (48%), Gaps = 15/204 (7%) Query: 106 KLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR 165 K+ +EG E++ E + LSH LV+L G C + ++ E+M G L N+L Sbjct: 218 KMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM 277 Query: 166 GAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR 225 F+ + + D + + +L S + ++RD+ A N L++ K+SDFG+ R Sbjct: 278 RHRFQTQQ---LLEMCKDVCEAMEYLESK--QFLHRDLAARNCLVNDQGVVKVSDFGMTR 332 Query: 226 DGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRP 284 + D ST +A+PE + +++SD+++FGVL+ EI S GK + + R Sbjct: 333 -YVLDDEYTSSTGSKFPVKWASPEVLMYSKFSSKSDIWAFGVLMWEIYSLGK--MPYERF 389 Query: 285 AKEENLVDWA------RPYLTSKR 302 E A RP+L S+R Sbjct: 390 TNSETAEHIAQGLRLPRPHLASER 413 >3QUP-A nrPDB Length = 323 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 78/313 (24%), Positives = 131/313 (41%), Gaps = 40/313 (12%) Query: 57 FNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH- 115 ++ + + F ++G+G FG V + L + + G+ + +AVK L + Sbjct: 15 LEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQ------EDGSFVKVAVKMLKADIIASSD 68 Query: 116 -REWLTEINYLGQLSHPNLVKLIGYCLEDEHR------LLVYEFMQKGSLENHLF--RRG 166 E+L E + + HP++ KL+G L + +++ FM+ G L L R G Sbjct: 69 IEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIG 128 Query: 167 AYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD 226 LP V +D A G+ +L S I+RD+ A N +L D ++DFGL+R Sbjct: 129 ENPFNLPLQTLVRFMVDIACGMEYLSSR--NFIHRDLAARNCMLAEDMTVCVADFGLSRK 186 Query: 227 GPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK 286 GD + A E ++ SDV++FGV + EI++ + Sbjct: 187 IYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQT-------- 238 Query: 287 EENLVDWARPYLTSKRKVL---LIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMD 343 PY + + LI NRL PE + + QC S +PK RP+ Sbjct: 239 ---------PYAGIENAEIYNYLIGGNRLKQP--PECMEEVYDLMYQCWSADPKQRPSFT 287 Query: 344 QVVRALQQLQDNL 356 + L+ + +L Sbjct: 288 CLRMELENILGHL 300 >5XZW-A nrPDB Length = 471 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 81/314 (25%), Positives = 138/314 (43%), Gaps = 60/314 (19%) Query: 28 SSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLD 87 S+ K++S +A+ T S K+ F + + D V+G+G F V K Sbjct: 165 SNLKNTSKIASPGLTSSTASSMVANKTGIFKDFSII------DEVVGQGAFATVKKA--- 215 Query: 88 ESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT-EINYLGQLSHPNLVKLIGYCLEDEHR 146 + TG AVK +++ G+ + +T E+ L +L+HP +V+L G+ + E Sbjct: 216 ------IERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFYEDTESY 269 Query: 147 LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKAS 206 +V EF+ G L + + GA + ++ + ++HS + + +RD+K Sbjct: 270 YMVMEFVSGGDLMDFVAAHGAVGEDAGR----EISRQILTAIKYIHS--MGISHRDLKPD 323 Query: 207 NILLDAD--YNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAP-------------EYM 251 NIL++ D K++DFGLA+ G+ S++ T GT Y AP EY Sbjct: 324 NILIEQDDPVLVKITDFGLAK--VQGNGSFMKT-FCGTLAYVAPEVIRGKDTSVSPDEYE 380 Query: 252 SSGHLNARSDVYSFGVLLLEILSGK----------------RALDHNRPAKEENLVDWAR 295 ++ D++S G L+ IL+G R H P K+ + + AR Sbjct: 381 ERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEAR 440 Query: 296 PYLTSKRKVLLIVD 309 ++ S LL VD Sbjct: 441 DFIDS----LLQVD 450 >5D9K-A nrPDB Length = 330 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 67/209 (32%), Positives = 103/209 (49%), Gaps = 22/209 (10%) Query: 72 VIGEGGFGCVF----KGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQ 127 V+G+G FG VF D L K + V+ + + R+ L E+N Sbjct: 37 VLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKME--RDILVEVN---- 90 Query: 128 LSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAK 186 HP +VKL Y + E +L L+ +F++ G L L + + + F +AL Sbjct: 91 --HPFIVKL-HYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL---- 143 Query: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYA 246 L LHS + +IYRD+K NILLD + + KL+DFGL+++ D + GT Y Sbjct: 144 ALDHLHS--LGIIYRDLKPENILLDEEGHIKLTDFGLSKESI--DHEKKAYSFCGTVEYM 199 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSG 275 APE ++ +D +SFGVL+ E+L+G Sbjct: 200 APEVVNRRGHTQSADWWSFGVLMFEMLTG 228 >4JXF-A nrPDB Length = 266 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 63/241 (26%), Positives = 109/241 (45%), Gaps = 22/241 (9%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH---REWLTEI 122 +F+ +++G+G F V++ ES TGL +A+K ++++ + E+ Sbjct: 8 DFKVGNLLGKGSFAGVYRA---ESI------HTGLEVAIKMIDKKAMYKAGMVQRVQNEV 58 Query: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 QL HP++++L Y + + LV E G + +L R KP + Sbjct: 59 KIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNR---VKPFSENEARHFMH 115 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 G+ +LHS +++RD+ SN+LL + N K++DFGLA M + + + GT Sbjct: 116 QIITGMLYLHSH--GILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYT--LCGT 171 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEEN---LVDWARPYLT 299 Y +PE + SDV+S G + +L G+ D + N L D+ P Sbjct: 172 PNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFL 231 Query: 300 S 300 S Sbjct: 232 S 232 >3Q53-A nrPDB Length = 306 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 59/205 (28%), Positives = 102/205 (49%), Gaps = 20/205 (9%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IG+G G V+ T TG +A++++N + + EI + + +PN Sbjct: 29 IGQGASGTVY---------TAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPN 79 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 +V + L + +V E++ GSL + + + R + + L FLH Sbjct: 80 IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCR-----ECLQALEFLH 134 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGL-ARDGPMGDLSYVSTRVMGTYGYAAPEYM 251 S+ +VI+RDIK+ NILL D + KL+DFG A+ P + S ST V GT + APE + Sbjct: 135 SN--QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP--EQSKRSTMV-GTPYWMAPEVV 189 Query: 252 SSGHLNARSDVYSFGVLLLEILSGK 276 + + D++S G++ +E++ G+ Sbjct: 190 TRKAYGPKVDIWSLGIMAIEMIEGE 214 >6FD3-A nrPDB Length = 300 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 105/215 (48%), Gaps = 20/215 (9%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IG+G G V+ T TG +A+K++N + + EI + + +PN Sbjct: 30 IGQGASGTVY---------TALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPN 80 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 +V + L + +V E++ GSL + + + R + + L FLH Sbjct: 81 IVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCR-----ECLQALDFLH 135 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGL-ARDGPMGDLSYVSTRVMGTYGYAAPEYM 251 S+ +VI+RDIK+ NILL D + KL+DFG A+ P + S ST V GT + APE + Sbjct: 136 SN--QVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP--EQSKRSTMV-GTPYWMAPEVV 190 Query: 252 SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK 286 + + D++S G++ +E++ G+ + P + Sbjct: 191 TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLR 225 >4K33-A nrPDB Length = 325 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 65/218 (29%), Positives = 105/218 (48%), Gaps = 22/218 (10%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-REWLTEINYLGQL-SH 130 +GEG FG V + + + + +AVK L + + ++E+ + + H Sbjct: 44 LGEGAFGQVVMA--EAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKH 101 Query: 131 PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR---GAYF-----KP----LPWFLRV 178 N++ L+G C + ++ E+ KG+L L R G + KP L + V Sbjct: 102 KNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQLTFKDLV 161 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR 238 + A A+G+ +L S K I+RD+ A N+L+ D K++DFGLARD + +L Y Sbjct: 162 SCAYQVARGMEYLASQ--KCIHRDLAARNVLVTEDNVMKIADFGLARD--VHNLDYYKET 217 Query: 239 VMG--TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 G + APE + +SDV+SFGVLL EI + Sbjct: 218 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFT 255 >4EBW-A nrPDB Length = 304 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 75/277 (27%), Positives = 122/277 (44%), Gaps = 34/277 (12%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYLGQLSH 130 IGEG FG V +G ++P P L +A+K RE +L E + Q H Sbjct: 45 CIGEGQFGDVHQG----IYMSPENPA--LAVAIKTCKNCTSDSVREKFLQEALTMRQFDH 98 Query: 131 PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAF 190 P++VKLIG E+ ++ E G L + L R L A + LA+ Sbjct: 99 PHIVKLIGVITENP-VWIIMELCTLGELRSFLQVRKYSLDLASLIL---YAYQLSTALAY 154 Query: 191 LHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV-STRVMGTYGYAAPE 249 L S + ++RDI A N+L+ ++ KL DFGL+R M D +Y +++ + APE Sbjct: 155 LESK--RFVHRDIAARNVLVSSNDCVKLGDFGLSRY--MEDSTYYKASKGKLPIKWMAPE 210 Query: 250 YMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRK-VLLIV 308 ++ + SDV+ FGV + EI L+ +P+ K V+ + Sbjct: 211 SINFRRFTSASDVWMFGVCMWEI-----------------LMHGVKPFQGVKNNDVIGRI 253 Query: 309 DNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQV 345 +N P + S+ +C +++P RP ++ Sbjct: 254 ENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTEL 290 >4WNO-A nrPDB Length = 287 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 68/234 (29%), Positives = 106/234 (45%), Gaps = 39/234 (16%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL-TEINYL 125 F +IG G F VFKG + L +AVK +N++ + L EI L Sbjct: 20 FSRKDLIGHGAFAVVFKGR--------HRAAHDLEVAVKCINKKNLAKSQTLLGKEIKIL 71 Query: 126 GQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLF-RRGAYFKPLPWFLRVNVALDA 184 +L H N+V L + LV E+ G L ++L R + FL+ Sbjct: 72 KELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQ-----QI 126 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLD------ADYNA---KLSDFGLARDGPMGDLSYV 235 A + LHS +I+RD+K NILL A+ N+ K++DFG AR Y+ Sbjct: 127 AGAMRLLHSK--GIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFAR--------YL 176 Query: 236 STRVM-----GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRP 284 + +M G+ Y APE + S H + ++D++S G ++ + L+GK + P Sbjct: 177 QSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSP 230 >2JDO-A nrPDB Length = 342 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 68/230 (29%), Positives = 102/230 (44%), Gaps = 25/230 (10%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE--- 117 K+ +F ++G+G FG V + + TG A+K L +E E Sbjct: 6 KVTMNDFDYLKLLGKGTFGKV---------ILVREKATGRYYAMKILRKEVIIAKDEVAH 56 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 +TE L HP L L Y + RL V E+ G L HL R + + F Sbjct: 57 TVTESRVLQNTRHPFLTAL-KYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFY 115 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 + L +LHS V+YRDIK N++LD D + K++DFGL ++G + D + + Sbjct: 116 GAEIV----SALEYLHSR--DVVYRDIKLENLMLDKDGHIKITDFGLCKEG-ISDGATMK 168 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRAL---DHNR 283 T GT Y APE + D + GV++ E++ G+ DH R Sbjct: 169 T-FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHER 217 >5KCV-A nrPDB Length = 460 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 72/250 (28%), Positives = 109/250 (43%), Gaps = 28/250 (11%) Query: 31 KSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDEST 90 +S S + E E+ + P T NE F ++G+G FG V Sbjct: 135 RSGSPSDNSGAEEMEVSLAKPKHRVTMNE-------FEYLKLLGKGTFGKV--------- 178 Query: 91 LTPTKPGTGLVIAVKKLNQEGFQGHRE---WLTEINYLGQLSHPNLVKLIGYCLEDEHRL 147 + + TG A+K L +E E LTE L HP L L Y + RL Sbjct: 179 ILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTAL-KYSFQTHDRL 237 Query: 148 -LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKAS 206 V E+ G L HL R + + F + L +LHS+ V+YRD+K Sbjct: 238 CFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV----SALDYLHSEK-NVVYRDLKLE 292 Query: 207 NILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFG 266 N++LD D + K++DFGL ++G + D + + T GT Y APE + D + G Sbjct: 293 NLMLDKDGHIKITDFGLCKEG-IKDGATMKT-FCGTPEYLAPEVLEDNDYGRAVDWWGLG 350 Query: 267 VLLLEILSGK 276 V++ E++ G+ Sbjct: 351 VVMYEMMCGR 360 >2J0K-A nrPDB Length = 656 Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 64/203 (31%), Positives = 95/203 (46%), Gaps = 14/203 (6%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 IGEG FG V +G ++P P + I K N ++L E + Q HP Sbjct: 397 CIGEGQFGDVHQGIY----MSPENPAMAVAIKTCK-NCTSDSVREKFLQEALTMRQFDHP 451 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 ++VKLIG E+ ++ E G L + L R L A + LA+L Sbjct: 452 HIVKLIGVITENP-VWIIMELCTLGELRSFLQVRKFSLDLASLIL---YAYQLSTALAYL 507 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV-STRVMGTYGYAAPEY 250 S + ++RDI A N+L+ A KL DFGL+R M D +Y +++ + APE Sbjct: 508 ESK--RFVHRDIAARNVLVSATDCVKLGDFGLSR--YMEDSTYYKASKGKLPIKWMAPES 563 Query: 251 MSSGHLNARSDVYSFGVLLLEIL 273 ++ + SDV+ FGV + EIL Sbjct: 564 INFRRFTSASDVWMFGVCMWEIL 586 >4BBM-A nrPDB Length = 331 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 62/209 (29%), Positives = 97/209 (46%), Gaps = 22/209 (10%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL--NQEGFQGHREWLTEINYLGQLS 129 ++GEG +G V K TG ++A+KK + + + + EI L QL Sbjct: 32 LVGEGSYGMVMKC---------RNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR 82 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLEN-HLFRRGAYFKPLPWFLRVNVALDAAKGL 188 H NLV L+ C + + LV+EF+ L++ LF G ++ + +L G+ Sbjct: 83 HENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYL-----FQIINGI 137 Query: 189 AFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAP 248 F HS +I+RDIK NIL+ KL DFG AR + V + T Y AP Sbjct: 138 GFCHSH--NIIHRDIKPENILVSQSGVVKLCDFGFAR--TLAAPGEVYDDEVATRWYRAP 193 Query: 249 EYMSSGHLNARS-DVYSFGVLLLEILSGK 276 E + ++ DV++ G L+ E+ G+ Sbjct: 194 ELLVGDVKYGKAVDVWAIGCLVTEMFMGE 222 >6QAU-A nrPDB Length = 280 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 65/228 (28%), Positives = 104/228 (45%), Gaps = 37/228 (16%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL-TEINYLGQLSH 130 ++G G F VF+G + T +A+K +N++ + L EI L +L H Sbjct: 18 LVGHGAFAVVFRGR--------HRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQH 69 Query: 131 PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAF 190 N+V L LV E+ G L ++L +G + +RV + AA + Sbjct: 70 ENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDT---IRVFLHQIAA-AMRI 125 Query: 191 LHSDPVKVIYRDIKASNILLD---------ADYNAKLSDFGLARDGPMGDLSYVSTRVM- 240 LHS +I+RD+K NILL + K++DFG AR Y+ + +M Sbjct: 126 LHSK--GIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFAR--------YLHSNMMA 175 Query: 241 ----GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRP 284 G+ Y APE + S H +A++D++S G ++ + L GK N P Sbjct: 176 ADLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSP 223 >4MVF-A nrPDB Length = 506 Score = 74.3 bits (181), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 101/209 (48%), Gaps = 22/209 (10%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLS 129 D +G+G +GCV+KG +D+ T + A+K+ ++ + + EI + +L Sbjct: 62 DEKLGQGTYGCVYKG-IDKVT--------NQLYAIKEEKKDRLKNINRFFQEIEIMKKLD 112 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 HPN+VKL D + L+ E L + + G++ + + + Sbjct: 113 HPNIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEKNA----ATIMKQIFSAIF 168 Query: 190 FLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYA 246 +LHS + +++RD+K N L + D K+ DFGL+++ G+ +T GT Y Sbjct: 169 YLHS--LNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEF---TTTKAGTPYYV 223 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSG 275 AP+ + G + + D++S GV++ +L G Sbjct: 224 APQVL-DGKYDKKCDIWSSGVIMYTLLCG 251 >3TXO-A nrPDB Length = 353 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 67/220 (30%), Positives = 101/220 (45%), Gaps = 23/220 (10%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE--- 117 +L NF V+G+G FG V + E TG + AVK L ++ + Sbjct: 19 RLGIDNFEFIRVLGKGSFGKVMLARVKE---------TGDLYAVKVLKKDVILQDDDVEC 69 Query: 118 WLTEINYLG-QLSHPNLVKLIGYCLEDEHRLL-VYEFMQKGSLENHLFRRGAYFKPLPWF 175 +TE L +HP L +L C + RL V EF+ G L H+ + + + F Sbjct: 70 TMTEKRILSLARNHPFLTQLFC-CFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARF 128 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 A + L FLH +IYRD+K N+LLD + + KL+DFG+ ++G ++ Sbjct: 129 ----YAAEIISALMFLHDK--GIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVT-- 180 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 + GT Y APE + D ++ GVLL E+L G Sbjct: 181 TATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCG 220 >3LMG-A nrPDB Length = 344 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 57/210 (27%), Positives = 102/210 (48%), Gaps = 12/210 (5%) Query: 66 NFRPDSVIGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 R V+G G FG V KG W+ E K + + K ++ FQ + + I Sbjct: 32 ELRKLKVLGSGVFGTVHKGVWIPEGE--SIKIPVCIKVIEDKSGRQSFQAVTDHMLAI-- 87 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 G L H ++V+L+G C +L V +++ GSL +H+ + P L +N + Sbjct: 88 -GSLDHAHIVRLLGLCPGSSLQL-VTQYLPLGSLLDHVRQHRGALGPQ---LLLNWGVQI 142 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYG 244 AKG+ +L +++R++ A N+LL + +++DFG+A P D + + Sbjct: 143 AKGMYYLEEH--GMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIK 200 Query: 245 YAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 + A E + G +SDV+S+GV + E+++ Sbjct: 201 WMALESIHFGKYTHQSDVWSYGVTVWELMT 230 >3DAK-A nrPDB Length = 290 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 74/291 (25%), Positives = 127/291 (43%), Gaps = 28/291 (9%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ-GHREWLTEINY 124 ++ VIG G V + P K +A+K++N E Q E L EI Sbjct: 11 DYELQEVIGSGATAVVQAAYC-----APKKEK----VAIKRINLEKCQTSMDELLKEIQA 61 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLEN---HLFRRGAYFK-PLPWFLRVNV 180 + Q HPN+V + + LV + + GS+ + H+ +G + L + Sbjct: 62 MSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATI 121 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGL-ARDGPMGDLSYVSTR- 238 + +GL +LH + I+RD+KA NILL D + +++DFG+ A GD++ R Sbjct: 122 LREVLEGLEYLHKN--GQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRK 179 Query: 239 -VMGTYGYAAPEYMSSGH-LNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 +GT + APE M + ++D++SFG+ +E+ +G P K Sbjct: 180 TFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMK--------VL 231 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 LT + + D + L + + CL +P+ RPT +++R Sbjct: 232 MLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLR 282 >2A1A-B nrPDB Length = 284 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 69/228 (30%), Positives = 97/228 (42%), Gaps = 44/228 (19%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 +F+ +IG GGFG VFK G VI K N E + E+ L Sbjct: 12 DFKEIELIGSGGFGQVFKA-------KHRIDGKTYVIKRVKYNNEKAE------REVKAL 58 Query: 126 GQLSHPNLVKLIG------YCLEDEHR----------LLVYEFMQKGSLENHLFRRGAYF 169 +L H N+V G Y E + + EF KG+LE + +R Sbjct: 59 AKLDHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRG-- 116 Query: 170 KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLA----R 225 + L L + + KG+ ++HS K+I RD+K SNI L K+ DFGL Sbjct: 117 EKLDKVLALELFEQITKGVDYIHSK--KLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKN 174 Query: 226 DGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEIL 273 DG TR GT Y +PE +SS D+Y+ G++L E+L Sbjct: 175 DGK-------RTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 215 >5O2C-A nrPDB Length = 380 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 69/223 (30%), Positives = 104/223 (46%), Gaps = 33/223 (14%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 R + D +G G F V+KG LD T + +KL + Q +E E Sbjct: 25 RFLKFDIELGRGAFKTVYKG-LDTETWVEV---AWCELQDRKLTKAEQQRFKE---EAEM 77 Query: 125 LGQLSHPNLVKLIGY---------CLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPL-PW 174 L L HPN+V+ C+ +LV E M G+L+ +L R FK + P Sbjct: 78 LKGLQHPNIVRFYDSWESILKGKKCI-----VLVTELMTSGTLKTYLKR----FKVMKPK 128 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY-NAKLSDFGLARDGPMGDLS 233 LR + KGL FLH+ +I+RD+K NI + + K+ D GLA + S Sbjct: 129 VLR-SWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA---TLMRTS 184 Query: 234 YVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 + + V+GT + APE M H + DVY+FG+ +LE+ + + Sbjct: 185 FAKS-VIGTPEFMAPE-MYEEHYDESVDVYAFGMCMLEMATSE 225 >2UV2-A nrPDB Length = 325 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 61/223 (27%), Positives = 105/223 (47%), Gaps = 31/223 (13%) Query: 63 ATRNFRPD---SVIGE---GGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR 116 TR+ P+ +IGE G FG V+K E T ++ A K ++ + + Sbjct: 29 VTRDLNPEDFWEIIGELGDGAFGKVYKAQNKE---------TSVLAAAKVIDTKSEEELE 79 Query: 117 EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 +++ EI+ L HPN+VKL+ + + ++ EF G+++ + +PL Sbjct: 80 DYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELE---RPLTESQ 136 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 V L +LH + K+I+RD+KA NIL D + KL+DFG++ + + Sbjct: 137 IQVVCKQTLDALNYLHDN--KIIHRDLKAGNILFTLDGDIKLADFGVS----AKNTRTIQ 190 Query: 237 TR--VMGTYGYAAPEYMSSGHLNAR-----SDVYSFGVLLLEI 272 R +GT + APE + R +DV+S G+ L+E+ Sbjct: 191 RRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEM 233 >4KRC-A nrPDB Length = 317 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 63/218 (28%), Positives = 110/218 (50%), Gaps = 18/218 (8%) Query: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-REWLTE 121 ++ F+ +G G + V+KG L+++T G+ +A+K++ + +G + E Sbjct: 3 SSSQFKQLEKLGNGTYATVYKG-LNKTT--------GVYVALKEVKLDSEEGTPSTAIRE 53 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKP--LPWFLRVN 179 I+ + +L H N+V+L + LV+EFM L+ ++ R P L L Sbjct: 54 ISLMKELKHENIVRLYDVIHTENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNLVKY 112 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 +GLAF H + K+++RD+K N+L++ KL DFGLAR + ++ S V Sbjct: 113 FQWQLLQGLAFCHEN--KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV 170 Query: 240 MGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGK 276 T Y AP+ M S + D++S G +L E+++GK Sbjct: 171 --TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGK 206 >4FG9-A nrPDB Length = 320 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 66/214 (30%), Positives = 100/214 (46%), Gaps = 24/214 (11%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL-TEINY 124 +FR V+G G F E L K LV A+K + +E +G + EI Sbjct: 21 DFR--DVLGTGAFS--------EVILAEDKRTQKLV-AIKCIAKEALEGKEGSMENEIAV 69 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 L ++ HPN+V L H L+ + + G L + + +G Y + L V LDA Sbjct: 70 LHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQV-LDA 128 Query: 185 AKGLAFLHSDPVKVIYRDIKASNIL---LDADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 K +LH + +++RD+K N+L LD D +SDFGL++ M D V + G Sbjct: 129 VK---YLHD--LGIVHRDLKPENLLYYSLDEDSKIMISDFGLSK---MEDPGSVLSTACG 180 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 T GY APE ++ + D +S GV+ +L G Sbjct: 181 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCG 214 >2F57-A nrPDB Length = 317 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 97/210 (46%), Gaps = 30/210 (14%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IGEG G V T+ TG +AVKK++ Q E+ + H N Sbjct: 53 IGEGSTGIV---------CIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDN 103 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 +V + L + +V EF++ G+L + + + + V L + L++LH Sbjct: 104 VVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQI-----ATVCLSVLRALSYLH 158 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV------MGTYGYA 246 + VI+RDIK+ +ILL +D KLSDFG + VS V +GT + Sbjct: 159 NQ--GVIHRDIKSDSILLTSDGRIKLSDFGFC--------AQVSKEVPKRKSLVGTPYWM 208 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSGK 276 APE +S D++S G++++E++ G+ Sbjct: 209 APEVISRLPYGTEVDIWSLGIMVIEMIDGE 238 >3PVW-A nrPDB Length = 695 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 65/224 (29%), Positives = 103/224 (45%), Gaps = 28/224 (12%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF---QGHR 116 + L +F +IG GGFG V+ K TG + A+K L+++ QG Sbjct: 184 IHLTMNDFSVHRIIGRGGFGEVYGC---------RKADTGKMYAMKCLDKKRIKMKQGET 234 Query: 117 EWLTEINYLGQLSHPN--LVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLP 173 L E L +S + + + Y +L + + M G L HL + G + + Sbjct: 235 LALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADM 294 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 F + L GL +H+ V+YRD+K +NILLD + ++SD GLA D S Sbjct: 295 RFYAAEIIL----GLEHMHNR--FVVYRDLKPANILLDEHGHVRISDLGLA-----CDFS 343 Query: 234 YVSTRV-MGTYGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSG 275 +GT+GY APE + G ++ +D +S G +L ++L G Sbjct: 344 KKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRG 387 >5E8V-A nrPDB Length = 316 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 82/322 (25%), Positives = 140/322 (43%), Gaps = 64/322 (19%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLG--Q 127 D+++G+G F V+K L ++T + +AVK E + W TE + Sbjct: 14 DTLVGKGRFAEVYKAKLKQNTSEQFE-----TVAVKIFPYEEYAS---WKTEKDIFSDIN 65 Query: 128 LSHPNLVKLIGYCLEDEHR--------LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 L H N+++ L E R L+ F KG+L+ +L R + W Sbjct: 66 LKHENILQF----LTAEERKTELGKQYWLITAFHAKGNLQEYLTRH-----VISWEDLRK 116 Query: 180 VALDAAKGLAFLHSD-------PVKVIYRDIKASNILLDADYNAKLSDFGLA--RDGPMG 230 + A+G+A LHSD + +++RD+K+SNIL+ D L DFGL+ D + Sbjct: 117 LGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLS 176 Query: 231 DLSYVSTRVMGTYGYAAPEYMSSGHLN-------ARSDVYSFGVLLLEILSGKRALDHNR 283 ++ +GT Y APE ++S +N ++DVYS ++L E+ S A+ + Sbjct: 177 VDDLANSGQVGTARYMAPEVLASA-MNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVK 235 Query: 284 PAKEENLVDWARPYLTSKRK---VLLIVDNRLDTQYLPE--------EAVRM-ASVAVQC 331 D+ P+ + R+ V + DN L PE + ++M +C Sbjct: 236 --------DYEPPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTEC 287 Query: 332 LSFEPKSRPTMDQVVRALQQLQ 353 +P++R T V +L+ Sbjct: 288 WDHDPEARLTAQCVAERFSELE 309 >5UUU-A nrPDB Length = 547 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 67/241 (27%), Positives = 111/241 (46%), Gaps = 29/241 (12%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF---QGHR 116 + L +F +IG GGFG V+ K TG + A+K L+++ QG Sbjct: 193 IHLTMNDFSVHRIIGRGGFGEVYGC---------RKADTGKMYAMKCLDKKRIKMKQGET 243 Query: 117 EWLTEINYLGQLSHPN--LVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLP 173 L E L +S + + + Y +L + + M G L HL + G + + Sbjct: 244 LALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADM 303 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 F + L GL +H+ V+YRD+K +NILLD + ++SD GLA D S Sbjct: 304 RFYAAEIIL----GLEHMHNR--FVVYRDLKPANILLDEHGHVRISDLGLA-----CDFS 352 Query: 234 YVSTRV-MGTYGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 +GT+GY APE + G ++ +D +S G +L ++L G ++ K+++ + Sbjct: 353 KKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHK-TKDKHEI 411 Query: 292 D 292 D Sbjct: 412 D 412 >6HXF-B nrPDB Length = 302 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 59/223 (26%), Positives = 105/223 (47%), Gaps = 35/223 (15%) Query: 65 RNFRPDSV------IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW 118 R+ P+ V +G+G FG V+K E TG + A K + + + ++ Sbjct: 13 RDLDPNEVWEIVGELGDGAFGKVYKAKNKE---------TGALAAAKVIETKSEEELEDY 63 Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFR--RGAYFKPLPWFL 176 + EI L HP +VKL+G D ++ EF G+++ + RG + Sbjct: 64 IVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVC 123 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 R + L FLHS ++I+RD+KA N+L+ + + +L+DFG++ +L + Sbjct: 124 R-----QMLEALNFLHSK--RIIHRDLKAGNVLMTLEGDIRLADFGVS----AKNLKTLQ 172 Query: 237 TR--VMGTYGYAAPEY-----MSSGHLNARSDVYSFGVLLLEI 272 R +GT + APE M + ++D++S G+ L+E+ Sbjct: 173 KRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEM 215 >1S9I-A nrPDB Length = 354 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 62/217 (28%), Positives = 109/217 (50%), Gaps = 19/217 (8%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWL 119 +L +F S +G G G V K +P +GL++A K ++ E R + + Sbjct: 12 ELKDDDFERISELGAGNGGVVTK--------VQHRP-SGLIMARKLIHLEIKPAIRNQII 62 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 E+ L + + P +V G D + E M GSL+ L K +P + Sbjct: 63 RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL----KEAKRIPEEILGK 118 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 V++ +GLA+L + ++++RD+K SNIL+++ KL DFG++ G + D ++ Sbjct: 119 VSIAVLRGLAYLR-EKHQIMHRDVKPSNILVNSRGEIKLCDFGVS--GQLID--SMANSF 173 Query: 240 MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 +GT Y APE + H + +SD++S G+ L+E+ G+ Sbjct: 174 VGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGR 210 >4CFF-A nrPDB Length = 571 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 85/309 (27%), Positives = 137/309 (44%), Gaps = 48/309 (15%) Query: 45 EILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAV 104 E+L P+ ++ ++ ++ +G G FG V G E LT G +AV Sbjct: 13 EVLFQGPMAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIG---EHQLT------GHKVAV 63 Query: 105 KKLNQEGFQGHR---EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENH 161 K LN++ + + EI L HP+++KL +V E++ G L ++ Sbjct: 64 KILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDY 123 Query: 162 LFRRGAY--FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLS 219 + + G + F ++ A+D + H V++RD+K N+LLDA NAK++ Sbjct: 124 ICKHGRVEEMEARRLFQQILSAVD------YCHRH--MVVHRDLKPENVLLDAHMNAKIA 175 Query: 220 DFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNA--RSDVYSFGVLLLEILSGKR 277 DFGL+ M D ++ T G+ YAAPE + SG L A D++S GV+L +L G Sbjct: 176 DFGLS--NMMSDGEFLRTSC-GSPNYAAPEVI-SGRLYAGPEVDIWSCGVILYALLCGTL 231 Query: 278 ALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVR-MASVAVQCLSFEP 336 D D P L K R Y+PE R +A++ + L +P Sbjct: 232 PFD-----------DEHVPTLFKK--------IRGGVFYIPEYLNRSVATLLMHMLQVDP 272 Query: 337 KSRPTMDQV 345 R T+ + Sbjct: 273 LKRATIKDI 281 >1U59-A nrPDB Length = 287 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 76/285 (26%), Positives = 127/285 (44%), Gaps = 36/285 (12%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLS 129 D +G G FG V +G K + I V K E E + E + QL Sbjct: 15 DIELGCGNFGSVRQG-----VYRMRKKQIDVAIKVLKQGTEKADTE-EMMREAQIMHQLD 68 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 +P +V+LIG C + E +LV E G L L + + +P + + G+ Sbjct: 69 NPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKR---EEIPVSNVAELLHQVSMGMK 124 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY--GYAA 247 +L ++RD+ A N+LL + AK+SDFGL++ D SY + R G + + A Sbjct: 125 YLEEK--NFVHRDLAARNVLLVNRHYAKISDFGLSK-ALGADDSYYTARSAGKWPLKWYA 181 Query: 248 PEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK-RKVLL 306 PE ++ ++RSDV+S+GV + E LS + +PY K +V+ Sbjct: 182 PECINFRKFSSRSDVWSYGVTMWEALSYGQ-----------------KPYKKMKGPEVMA 224 Query: 307 IVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP---TMDQVVRA 348 ++ + PE + ++ C ++ + RP T++Q +RA Sbjct: 225 FIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRA 269 >3MV5-A nrPDB Length = 342 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 64/220 (29%), Positives = 99/220 (45%), Gaps = 21/220 (9%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE--- 117 ++ F ++G+G FG V + + TG A+K L +E E Sbjct: 6 RVTMNEFEYLKLLGKGTFGKV---------ILVKEKATGRYYAMKILKKEVIVAKDEVAH 56 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 LTE L HP L L Y + RL V E+ G L HL R + + F Sbjct: 57 TLTENRVLQNSRHPFLTAL-KYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFY 115 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 + L +LHS+ V+YRD+K N++LD D + K++DFGL ++G + D + + Sbjct: 116 GAEIV----SALDYLHSEK-NVVYRDLKLENLMLDKDGHIKITDFGLCKEG-IKDGATMK 169 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 T GT Y APE + D + GV++ E++ G+ Sbjct: 170 T-FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR 208 >4FIE-A nrPDB Length = 423 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 65/239 (27%), Positives = 107/239 (44%), Gaps = 31/239 (12%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IGEG G V + S G ++AVKK++ Q E+ + H N Sbjct: 159 IGEGSTGIVCIATVRSS---------GKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHEN 209 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 +V++ L + +V EF++ G+L + + + + V L + L+ LH Sbjct: 210 VVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQI-----AAVCLAVLQALSVLH 264 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV------MGTYGYA 246 + VI+RDIK+ +ILL D KLSDFG + VS V +GT + Sbjct: 265 AQ--GVIHRDIKSDSILLTHDGRVKLSDFGFC--------AQVSKEVPRRKSLVGTPYWM 314 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV-DWARPYLTSKRKV 304 APE +S D++S G++++E++ G+ + P K ++ D P L + KV Sbjct: 315 APELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKV 373 >3REP-A nrPDB Length = 271 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 68/265 (25%), Positives = 119/265 (44%), Gaps = 34/265 (12%) Query: 97 GTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDE--HRLLVYEFMQ 154 G +V+ V K+ + R++ E L SHPN++ ++G C H L+ +M Sbjct: 33 GNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMP 92 Query: 155 KGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY 214 GSL N + G F + V ALD A+G+AFLH+ + + + ++++D D Sbjct: 93 YGSLYN-VLHEGTNFV-VDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDM 150 Query: 215 NAKLSDFGLARDGPMGDL--SYVSTRVMGTYGYAAPEYMSSG--HLNARS-DVYSFGVLL 269 A++S M D+ S+ S M + APE + N RS D++SF VLL Sbjct: 151 TARIS---------MADVKFSFQSPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLL 201 Query: 270 LEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAV 329 E+++ +E D L++ + + L P + ++ + Sbjct: 202 WELVT-----------REVPFAD-----LSNMEIGMKVALEGLRPTIPPGISPHVSKLMK 245 Query: 330 QCLSFEPKSRPTMDQVVRALQQLQD 354 C++ +P RP D +V L+++QD Sbjct: 246 ICMNEDPAKRPKFDMIVPILEKMQD 270 >4XI2-A nrPDB Length = 446 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 68/241 (28%), Positives = 112/241 (46%), Gaps = 34/241 (14%) Query: 73 IGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 +G G FG V G W G K+ +EG E++ E + LSH Sbjct: 195 LGTGQFGVVKYGKW------------RGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHE 242 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 LV+L G C + ++ E+M G L N+L F+ + + D + + +L Sbjct: 243 KLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQ---LLEMCKDVCEAMEYL 299 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT---YGYAAP 248 S + ++RD+ A N L++ K+SDFGL+R + D Y S+ +G+ ++ P Sbjct: 300 ESK--QFLHRDLAARNCLVNDQGVVKVSDFGLSR--YVLDDEYTSS--VGSKFPVRWSPP 353 Query: 249 EYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWA------RPYLTSK 301 E + +++SD+++FGVL+ EI S GK + + R E A RP+L S+ Sbjct: 354 EVLMYSKFSSKSDIWAFGVLMWEIYSLGK--MPYERFTNSETAEHIAQGLRLYRPHLASE 411 Query: 302 R 302 R Sbjct: 412 R 412 >6E4F-A nrPDB Length = 290 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 63/218 (28%), Positives = 104/218 (47%), Gaps = 28/218 (12%) Query: 74 GEGGFGCVFKGW-LDESTLTPTKP-GTGLVIAVK------------KLNQEGFQGHREWL 119 G G G + W +D LT K GTG VK K+ +EG E++ Sbjct: 17 GTAGLG--YGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFI 74 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 E + LSH LV+L G C + ++ E+M G L N+L F+ + Sbjct: 75 EEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQ---LLE 131 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 + D + + +L S + ++RD+ A N L++ K+SDFGL+R + D Y S+ Sbjct: 132 MCKDVCEAMEYLESK--QFLHRDLAARNCLVNDQGVVKVSDFGLSR--YVLDDEYTSS-- 185 Query: 240 MGT---YGYAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 +G+ ++ PE + +++SD+++FGVL+ EI S Sbjct: 186 VGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYS 223 >5O2B-A nrPDB Length = 285 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 69/223 (30%), Positives = 104/223 (46%), Gaps = 33/223 (14%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 R + D +G G F V+KG LD T + +KL + Q +E E Sbjct: 16 RFLKFDIELGRGAFKTVYKG-LDTETWVEV---AWCELQDRKLTKAEQQRFKE---EAEM 68 Query: 125 LGQLSHPNLVKLIGY---------CLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPL-PW 174 L L HPN+V+ C+ +LV E M G+L+ +L R FK + P Sbjct: 69 LKGLQHPNIVRFYDSWESILKGKKCI-----VLVTELMTSGTLKTYLKR----FKVMKPK 119 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY-NAKLSDFGLARDGPMGDLS 233 LR + KGL FLH+ +I+RD+K NI + + K+ D GLA + S Sbjct: 120 VLR-SWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA---TLMRTS 175 Query: 234 YVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 + + V+GT + APE M H + DVY+FG+ +LE+ + + Sbjct: 176 FAKS-VIGTPEFMAPE-MYEEHYDESVDVYAFGMCMLEMATSE 216 >5JN2-A nrPDB Length = 525 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 69/262 (26%), Positives = 120/262 (45%), Gaps = 20/262 (7%) Query: 17 GKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEG 76 G+ G + +S A G+ L +TP F + + + ++ V+G+G Sbjct: 20 GQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATP-GMFVQHSTAIFSDRYKGQRVLGKG 78 Query: 77 GFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKL 136 FG V L + +T + VI+ +++ Q+ L E+ L QL HPN++KL Sbjct: 79 SFGEVI---LCKDKITGQECAVK-VISKRQVKQK--TDKESLLREVQLLKQLDHPNIMKL 132 Query: 137 IGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPV 196 + + + LV E G L + + R K + G+ ++H + Sbjct: 133 YEFFEDKGYFYLVGEVYTGGELFDEIISR----KRFSEVDAARIIRQVLSGITYMHKN-- 186 Query: 197 KVIYRDIKASNILLDA---DYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSS 253 K+++RD+K N+LL++ D N ++ DFGL+ + S +GT Y APE + Sbjct: 187 KIVHRDLKPENLLLESKSKDANIRIIDFGLS---THFEASKKMKDKIGTAYYIAPEVL-H 242 Query: 254 GHLNARSDVYSFGVLLLEILSG 275 G + + DV+S GV+L +LSG Sbjct: 243 GTYDEKCDVWSTGVILYILLSG 264 >5TQX-A nrPDB Length = 655 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 64/221 (28%), Positives = 98/221 (44%), Gaps = 28/221 (12%) Query: 73 IGEGGFG--CVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYLGQLS 129 +G GGFG C+++ L IA+K E +RE W EI + +L+ Sbjct: 16 LGTGGFGNVCLYQ-----------HRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLN 64 Query: 130 HPNLVKLIGY-----CLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 H N+VK L + LL E+ G L L + L +++ D Sbjct: 65 HANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRK-LLNKPENCCGLKESQILSLLSDI 123 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLD---ADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 G+ +LH + K+I+RD+K NI+L K+ D G A+D G+L T +G Sbjct: 124 GSGIRYLHEN--KIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELC---TEFVG 178 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHN 282 T Y APE + A D +SFG ++ E ++G R H+ Sbjct: 179 TLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHH 219 >2XNP-A nrPDB Length = 279 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 54/161 (33%), Positives = 84/161 (52%), Gaps = 7/161 (4%) Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLL--VYEFMQKGSLENHLFR--RGAYFKPLPW 174 ++E+N L +L HPN+V+ ++ + L V E+ + G L + + + + + + Sbjct: 53 VSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEF 112 Query: 175 FLRVNVALDAAKGLAFLHSDP-VKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 LRV L A SD V++RD+K +N+ LD N KL DFGLAR D S Sbjct: 113 VLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILN-HDTS 171 Query: 234 YVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 + T V GT Y +PE M+ N +SD++S G LL E+ + Sbjct: 172 FAKTFV-GTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCA 211 >5EZV-A nrPDB Length = 560 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 82/281 (29%), Positives = 126/281 (44%), Gaps = 48/281 (17%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR---EWLTEINYLGQLS 129 +G G FG V G E LT G +AVK LN++ + + EI L Sbjct: 36 LGVGTFGKVKIG---EHQLT------GHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFR 86 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAY--FKPLPWFLRVNVALDAAKG 187 HP+++KL +V E++ G L +++ + G + F ++ A+D Sbjct: 87 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD---- 142 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAA 247 + H V++RD+K N+LLDA NAK++DFGL+ M D ++ T G+ YAA Sbjct: 143 --YCHRH--MVVHRDLKPENVLLDAHMNAKIADFGLS--NMMSDGEFLRTSC-GSPNYAA 195 Query: 248 PEYMSSGHLNA--RSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVL 305 PE + SG L A D++S GV+L +L G D D P L K Sbjct: 196 PEVI-SGRLYAGPEVDIWSCGVILYALLCGTLPFD-----------DEHVPTLFKK---- 239 Query: 306 LIVDNRLDTQYLPEEAVR-MASVAVQCLSFEPKSRPTMDQV 345 R Y+PE R +A++ + L +P R T+ + Sbjct: 240 ----IRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 276 >5DBX-A nrPDB Length = 328 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 55/183 (30%), Positives = 96/183 (52%), Gaps = 11/183 (6%) Query: 102 IAVKKLNQEGFQ-GHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLEN 160 +A+K++N E Q E L EI + Q SHPN+V + + LV + + GS+ + Sbjct: 39 VAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLD 98 Query: 161 ---HLFRRGAYFK-PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA 216 ++ RG + L + + + +GL +LH + I+RD+KA NILL D + Sbjct: 99 IIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRN--GQIHRDLKAGNILLGEDGSV 156 Query: 217 KLSDFGL-ARDGPMGDLSYVSTR--VMGTYGYAAPEYMSSGH-LNARSDVYSFGVLLLEI 272 +++DFG+ A GD++ R +GT + APE M + ++D++SFG+ +E+ Sbjct: 157 QIADFGVSAFLATGGDVTRNKVRKDFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIEL 216 Query: 273 LSG 275 +G Sbjct: 217 ATG 219 >4XBR-A nrPDB Length = 366 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 72/275 (26%), Positives = 120/275 (43%), Gaps = 31/275 (11%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IGEG G V T +G ++AVKK++ Q E+ + H N Sbjct: 102 IGEGSTGIV---------CIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHEN 152 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 +V++ L + +V EF++ G+L + + + + V L + L+ LH Sbjct: 153 VVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQI-----AAVCLAVLQALSVLH 207 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV------MGTYGYA 246 + VI+RDIK+ +ILL D KLSDFG + VS V +GT + Sbjct: 208 AQ--GVIHRDIKSDSILLTHDGRVKLSDFGFC--------AQVSKEVPRRKSLVGTPYWM 257 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV-DWARPYLTSKRKVL 305 APE +S D++S G++++E++ G+ + P K ++ D P L + KV Sbjct: 258 APELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVS 317 Query: 306 LIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP 340 + LD + + A R + + F K+ P Sbjct: 318 PSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGP 352 >3ZZW-A nrPDB Length = 289 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 62/234 (26%), Positives = 104/234 (44%), Gaps = 27/234 (11%) Query: 57 FNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR 116 E+ L+ F + +GE FG V+KG L P +A+K L + R Sbjct: 3 LKEISLSAVRFMEE--LGEDRFGKVYKGHL----FGPAPGEQTQAVAIKTLKDKAEGPLR 56 Query: 117 E-WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAY------- 168 E + E +L HPN+V L+G +D+ +++ + G L L R + Sbjct: 57 EEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTD 116 Query: 169 --------FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSD 220 +P P F V++ A G+ +L S V+++D+ N+L+ N K+SD Sbjct: 117 DDRTVKSALEP-PDF--VHLVAQIAAGMEYLSSH--HVVHKDLATRNVLVYDKLNVKISD 171 Query: 221 FGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 GL R+ D + + + APE + G + SD++S+GV+L E+ S Sbjct: 172 LGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFS 225 >2Q0N-A nrPDB Length = 301 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 65/239 (27%), Positives = 107/239 (44%), Gaps = 31/239 (12%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IGEG G V T +G ++AVKK++ Q E+ + H N Sbjct: 37 IGEGSTGIV---------CIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHEN 87 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 +V++ L + +V EF++ G+L + + + + V L + L+ LH Sbjct: 88 VVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQI-----AAVCLAVLQALSVLH 142 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV------MGTYGYA 246 + VI+RDIK+ +ILL D KLSDFG + VS V +GT + Sbjct: 143 AQ--GVIHRDIKSDSILLTHDGRVKLSDFGFC--------AQVSKEVPRRKSLVGTPYWM 192 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV-DWARPYLTSKRKV 304 APE +S D++S G++++E++ G+ + P K ++ D P L + KV Sbjct: 193 APELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKV 251 >3ORP-A nrPDB Length = 311 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 44/138 (31%), Positives = 73/138 (52%), Gaps = 7/138 (5%) Query: 148 LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASN 207 +V E++ +L + + G P+ + V DA + L F H + +I+RD+K +N Sbjct: 93 IVMEYVDGVTLRDIVHTEG----PMTPKRAIEVIADACQALNFSHQN--GIIHRDVKPAN 146 Query: 208 ILLDADYNAKLSDFGLARD-GPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFG 266 I++ A K+ DFG+AR G+ + V+GT Y +PE ++ARSDVYS G Sbjct: 147 IMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLG 206 Query: 267 VLLLEILSGKRALDHNRP 284 +L E+L+G+ + P Sbjct: 207 CVLYEVLTGEPPFTGDSP 224 >4JDH-A nrPDB Length = 346 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 72/275 (26%), Positives = 120/275 (43%), Gaps = 31/275 (11%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IGEG G V + S G ++AVKK++ Q E+ + H N Sbjct: 82 IGEGSTGIVCIATVRSS---------GKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHEN 132 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 +V++ L + +V EF++ G+L + + + + V L + L+ LH Sbjct: 133 VVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQI-----AAVCLAVLQALSVLH 187 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV------MGTYGYA 246 + VI+RDIK+ +ILL D KLSDFG + VS V +GT + Sbjct: 188 AQ--GVIHRDIKSDSILLTHDGRVKLSDFGFC--------AQVSKEVPRRKSLVGTPYWM 237 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV-DWARPYLTSKRKVL 305 APE +S D++S G++++E++ G+ + P K ++ D P L + KV Sbjct: 238 APELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVS 297 Query: 306 LIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP 340 + LD + + A R + + F K+ P Sbjct: 298 PSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGP 332 >3A8W-A nrPDB Length = 345 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 54/168 (32%), Positives = 87/168 (51%), Gaps = 14/168 (8%) Query: 117 EWL-TEINYLGQLS-HPNLVKLIGYCLEDEHRLL-VYEFMQKGSLENHLFRRGAYFKPLP 173 +W+ TE + Q S HP LV L C + E RL V E++ G L H+ R+ + Sbjct: 54 DWVQTEKHVFEQASNHPFLVGLHS-CFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHA 112 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPM-GDL 232 F ++L L +LH +IYRD+K N+LLD++ + KL+D+G+ ++G GD Sbjct: 113 RFYSAEISL----ALNYLHER--GIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGD- 165 Query: 233 SYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 ++ GT Y APE + D ++ GVL+ E+++G+ D Sbjct: 166 --TTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFD 211 >3Q5I-A nrPDB Length = 504 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 51/164 (31%), Positives = 78/164 (47%), Gaps = 13/164 (7%) Query: 115 HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPW 174 H E EI+ L L HPN++KL + ++ LV EF + G L + R + + Sbjct: 90 HEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDA- 148 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD---YNAKLSDFGLARDGPMGD 231 N+ G+ +LH +++RDIK NILL+ N K+ DFGL+ Sbjct: 149 ---ANIMKQILSGICYLHKHN--IVHRDIKPENILLENKNSLLNIKIVDFGLS---SFFS 200 Query: 232 LSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 Y +GT Y APE + + N + DV+S GV++ +L G Sbjct: 201 KDYKLRDRLGTAYYIAPEVLKKKY-NEKCDVWSCGVIMYILLCG 243 >6FDY-U nrPDB Length = 276 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 60/206 (29%), Positives = 96/206 (46%), Gaps = 17/206 (8%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +G G + V+K + + T +A K LN+ + LTEI L + HP+ Sbjct: 19 LGSGTYATVYKAYAKKDTREVVAIKC---VAKKSLNKASVEN---LLTEIEILKGIRHPH 72 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 +V+L + + ++ L+ EF G L + R + LP + A L FLH Sbjct: 73 IVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTR----RILPEKVARVFMQQLASALQFLH 128 Query: 193 SDPVKVIYRDIKASNILLDA--DYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEY 250 + + D+K NILL + + KL+DFG A+ D +V + G+ Y APE Sbjct: 129 ER--NISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHV---LRGSPLYMAPEM 183 Query: 251 MSSGHLNARSDVYSFGVLLLEILSGK 276 + +AR D++S GV+L E L G+ Sbjct: 184 VCQRQYDARVDLWSMGVILYEALFGQ 209 >4PWN-A nrPDB Length = 274 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 64/222 (28%), Positives = 101/222 (45%), Gaps = 30/222 (13%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 R + D IG G F V+KG E+T+ + +KL + Q +E E Sbjct: 10 RFLKFDIEIGRGSFKTVYKGLDTETTVEVA----WCELQDRKLTKSERQRFKE---EAEM 62 Query: 125 LGQLSHPNLVKLIG---------YCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 L L HPN+V+ C+ +LV E M G+L+ +L R FK + Sbjct: 63 LKGLQHPNIVRFYDSWESTVKGKKCI-----VLVTELMTSGTLKTYLKR----FKVMKIK 113 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY-NAKLSDFGLARDGPMGDLSY 234 + + KGL FLH+ +I+RD+K NI + + K+ D GLA + + Sbjct: 114 VLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA---TLEKRAS 170 Query: 235 VSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 + V+GT + APE M + DVY+FG+ +LE+ + + Sbjct: 171 FAKSVIGTPEFMAPE-MYEEKYDESVDVYAFGMCMLEMATSE 211 >4REW-A nrPDB Length = 540 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 67/225 (29%), Positives = 107/225 (47%), Gaps = 23/225 (10%) Query: 98 TGLVIAVKKLNQEGFQGHR---EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQ 154 TG +AVK LN++ + + EI L HP+++KL +V E++ Sbjct: 30 TGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVS 89 Query: 155 KGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY 214 G L +++ + G + L + G+ + H V++RD+K N+LLDA Sbjct: 90 GGELFDYICKNGRLDEKESRRLFQQIL----SGVDYCHRH--MVVHRDLKPENVLLDAHM 143 Query: 215 NAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNA--RSDVYSFGVLLLEI 272 NAK++DFGL+ M D ++ T G+ YAAPE + SG L A D++S GV+L + Sbjct: 144 NAKIADFGLS--NMMSDGEFLRTSC-GSPNYAAPEVI-SGRLYAGPEVDIWSSGVILYAL 199 Query: 273 LSGKRALDHNR-PAKEENLVD-------WARPYLTSKRKVLLIVD 309 L G D + P + + D + P + S K +L VD Sbjct: 200 LCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVD 244 >3NYO-A nrPDB Length = 576 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 72/230 (31%), Positives = 108/230 (46%), Gaps = 22/230 (9%) Query: 59 ELKLATRN-FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ---G 114 E + T+N FR V+G+GGFG V + TG + A KKL ++ + G Sbjct: 177 ERQPVTKNTFRQYRVLGKGGFGEVCACQVR---------ATGKMYACKKLEKKRIKKRKG 227 Query: 115 HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLP 173 L E L +++ +V L Y E + L LV M G L+ H++ G P Sbjct: 228 EAMALNEKQILEKVNSRFVVSL-AYAYETKDALCLVLTLMNGGDLKFHIYHMGQ--AGFP 284 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 V A + GL LH + +++YRD+K NILLD + ++SD GLA P G Sbjct: 285 EARAVFYAAEICCGLEDLHRE--RIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQT- 341 Query: 234 YVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNR 283 + RV GT GY APE + + D ++ G LL E+++G+ + Sbjct: 342 -IKGRV-GTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRK 389 >4AGU-A nrPDB Length = 311 Score = 71.2 bits (173), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 65/209 (31%), Positives = 92/209 (44%), Gaps = 26/209 (12%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL--NQEGFQGHREWLTEINYLGQLSH 130 IGEG +G VFK TG ++A+KK +++ + L EI L QL H Sbjct: 11 IGEGSYGVVFKC---------RNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61 Query: 131 PNLVKLIGYCLEDEHRLLVYEFMQKGSL-ENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 PNLV L+ LV+E+ L E ++RG +P L ++ + + Sbjct: 62 PNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRG-----VPEHLVKSITWQTLQAVN 116 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR--DGPMGDLSYVSTRVMGTYGYAA 247 F H I+RD+K NIL+ KL DFG AR GP Y V T Y + Sbjct: 117 FCHKH--NCIHRDVKPENILITKHSVIKLCDFGFARLLTGPS---DYYDDEV-ATRWYRS 170 Query: 248 PEYM-SSGHLNARSDVYSFGVLLLEILSG 275 PE + DV++ G + E+LSG Sbjct: 171 PELLVGDTQYGPPVDVWAIGCVFAELLSG 199 >4UZD-A nrPDB Length = 287 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 58/223 (26%), Positives = 98/223 (43%), Gaps = 22/223 (9%) Query: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG---HREWL 119 A +F +G+G FG V+ +S ++A+K L + + + Sbjct: 6 ALEDFEIGRPLGKGKFGNVYLAREKQSKF---------ILALKVLFKAQLEKAGVEHQLR 56 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 E+ L HPN+++L GY + L+ E+ G++ L + + + Sbjct: 57 REVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRT----AT 112 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 + A L++ HS +VI+RDIK N+LL + K++DFG + P S T + Sbjct: 113 YITELANALSYCHSK--RVIHRDIKPENLLLGSAGELKIADFGWSVHAP----SSRRTTL 166 Query: 240 MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHN 282 GT Y PE + + + D++S GVL E L GK + N Sbjct: 167 CGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEAN 209 >5ES1-A nrPDB Length = 328 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 73/291 (25%), Positives = 125/291 (42%), Gaps = 51/291 (17%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 N+R IG+G F K L LT + +I +LN Q + E+ + Sbjct: 16 NYRLLRTIGKGNFA---KVKLARHILTGREVAIK-IIDKTQLNPSSLQ---KLFREVRIM 68 Query: 126 GQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRG--------AYFKPLPWFLR 177 L+HPN+VKL ++ LV E+ G + ++L G A F+ + Sbjct: 69 KGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQI----- 123 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 + + H +++RD+KA N+LLDA+ N K++DFG + + +G S + T Sbjct: 124 -------VSAVHYCHQK--NIVHRDLKAENLLLDAEANIKIADFGFSNEFTLG--SKLDT 172 Query: 238 RVMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 G+ YAAPE + + D++S GV+L ++SG D + NL + Sbjct: 173 -FCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGH------NLKELRER 225 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 L K +V + + S+ + L P R T++Q+++ Sbjct: 226 VLRGKYRVPFYMSTDCE------------SILRRFLVLNPAKRCTLEQIMK 264 >6C9D-A nrPDB Length = 459 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 61/226 (26%), Positives = 101/226 (44%), Gaps = 37/226 (16%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ--GHREWLTEIN 123 N+R IG+G F V L LT G +AVK +++ ++ E+ Sbjct: 22 NYRLQKTIGKGNFAKV---KLARHVLT------GREVAVKIIDKTQLNPTSLQKLFREVR 72 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRG--------AYFKPLPWF 175 + L+HPN+VKL ++ LV E+ G + ++L G A F+ + Sbjct: 73 IMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI--- 129 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 + + H +++RD+KA N+LLD D N K++DFG + + +G+ Sbjct: 130 ---------VSAVQYCHQK--YIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGN---K 175 Query: 236 STRVMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 G+ YAAPE + + DV+S GV+L ++SG D Sbjct: 176 LDEFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 221 >2OZO-A nrPDB Length = 613 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 75/285 (26%), Positives = 127/285 (44%), Gaps = 36/285 (12%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLS 129 D +G G FG V +G K + I V K E E + E + QL Sbjct: 341 DIELGCGNFGSVRQG-----VYRMRKKQIDVAIKVLKQGTEKADTE-EMMREAQIMHQLD 394 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 +P +V+LIG C + E +LV E G L L + + +P + + G+ Sbjct: 395 NPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKR---EEIPVSNVAELLHQVSMGMK 450 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY--GYAA 247 +L ++R++ A N+LL + AK+SDFGL++ D SY + R G + + A Sbjct: 451 YLEEK--NFVHRNLAARNVLLVNRHYAKISDFGLSK-ALGADDSYYTARSAGKWPLKWYA 507 Query: 248 PEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK-RKVLL 306 PE ++ ++RSDV+S+GV + E LS + +PY K +V+ Sbjct: 508 PECINFRKFSSRSDVWSYGVTMWEALSYGQ-----------------KPYKKMKGPEVMA 550 Query: 307 IVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP---TMDQVVRA 348 ++ + PE + ++ C ++ + RP T++Q +RA Sbjct: 551 FIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRA 595 >3HDN-A nrPDB Length = 373 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 61/208 (29%), Positives = 95/208 (45%), Gaps = 21/208 (10%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE---WLTEINYL-GQ 127 VIG+G FG V L + AVK L ++ +E ++E N L Sbjct: 45 VIGKGSFGKV---------LLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKN 95 Query: 128 LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 + HP LV L + V +++ G L HL R + +P F A + A Sbjct: 96 VKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARF----YAAEIASA 151 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAA 247 L +LHS + ++YRD+K NILLD+ + L+DFGL ++ + + ++ GT Y A Sbjct: 152 LGYLHS--LNIVYRDLKPENILLDSQGHIVLTDFGLCKEN--IEHNSTTSTFCGTPEYLA 207 Query: 248 PEYMSSGHLNARSDVYSFGVLLLEILSG 275 PE + + D + G +L E+L G Sbjct: 208 PEVLHKQPYDRTVDWWCLGAVLYEMLYG 235 >4RED-A nrPDB Length = 351 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 67/225 (29%), Positives = 107/225 (47%), Gaps = 23/225 (10%) Query: 98 TGLVIAVKKLNQEGFQGHR---EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQ 154 TG +AVK LN++ + + EI L HP+++KL +V E++ Sbjct: 38 TGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVS 97 Query: 155 KGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY 214 G L +++ + G + L + G+ + H V++RD+K N+LLDA Sbjct: 98 GGELFDYICKNGRLDEKESRRLFQQIL----SGVDYCHRH--MVVHRDLKPENVLLDAHM 151 Query: 215 NAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNA--RSDVYSFGVLLLEI 272 NAK++DFGL+ M D ++ T G+ YAAPE + SG L A D++S GV+L + Sbjct: 152 NAKIADFGLS--NMMSDGEFLRTSC-GSPNYAAPEVI-SGRLYAGPEVDIWSSGVILYAL 207 Query: 273 LSGKRALDHNR-PAKEENLVD-------WARPYLTSKRKVLLIVD 309 L G D + P + + D + P + S K +L VD Sbjct: 208 LCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVD 252 >4PDS-A nrPDB Length = 347 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 79/304 (25%), Positives = 132/304 (43%), Gaps = 54/304 (17%) Query: 38 AAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPG 97 A K L+S+ S N+ + D V+G+G F V K E T Sbjct: 4 ATSKIASPGLTSSTASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAI--ERT------- 54 Query: 98 TGLVIAVKKLNQEGFQGHREWLT-EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKG 156 TG +VK +++ G+ + +T E+ L +L+HP +V+L G+ + E +V EF+ G Sbjct: 55 TGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFYEDTESYYMVMEFVSGG 114 Query: 157 SLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD--Y 214 L + + GA + ++ + ++HS + + +RD+K NIL++ D Sbjct: 115 DLMDFVAAHGAVGEDAGR----EISRQILTAIKYIHS--MGISHRDLKPDNILIEQDDPV 168 Query: 215 NAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAP-------------EYMSSGHLNARSD 261 K++ FGLA+ G+ S++ T GT Y AP EY ++ D Sbjct: 169 LVKITAFGLAK--VQGNGSFMKT-FCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVD 225 Query: 262 VYSFGVLLLEILSGK----------------RALDHNRPAKEENLVDWARPYLTSKRKVL 305 ++S G L+ IL+G R H P K+ + + AR ++ S L Sbjct: 226 MWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDS----L 281 Query: 306 LIVD 309 L VD Sbjct: 282 LQVD 285 >4B8L-A nrPDB Length = 286 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 61/235 (25%), Positives = 101/235 (42%), Gaps = 25/235 (10%) Query: 47 LSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVK- 105 L+ P + FT ++ + RP +G+G FG V+ ++ L + K Sbjct: 4 LAEMPKRKFTIDDFDIG----RP---LGKGKFGNVYLAREKQNKFI-----MALKVLFKS 51 Query: 106 KLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR 165 +L +EG + + EI L HPN++++ Y + + L+ EF +G L L + Sbjct: 52 QLEKEGVE--HQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKH 109 Query: 166 GAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR 225 G + + + A L + H KVI+RDIK N+L+ K++DFG + Sbjct: 110 GRFDEQ----RSATFMEELADALHYCHER--KVIHRDIKPENLLMGYKGELKIADFGWSV 163 Query: 226 DGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 P S + GT Y PE + + + D++ GVL E L G D Sbjct: 164 HAP----SLRRRTMCGTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFD 214 >3UIU-A nrPDB Length = 306 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 69/241 (28%), Positives = 98/241 (40%), Gaps = 57/241 (23%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 +F+ +IG GGFG VFK G VI K N E + E+ L Sbjct: 13 DFKEIELIGSGGFGQVFKA-------KHRIDGKTYVIRRVKYNNEKAE------REVKAL 59 Query: 126 GQLSHPNLVKLIG--------------------YCLEDEHR---------LLVYEFMQKG 156 +L H N+V G Y E+ + EF KG Sbjct: 60 AKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKG 119 Query: 157 SLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA 216 +LE + +R + L L + + KG+ ++HS K+I+RD+K SNI L Sbjct: 120 TLEQWIEKRRG--EKLDKVLALELFEQITKGVDYIHSK--KLIHRDLKPSNIFLVDTKQV 175 Query: 217 KLSDFGLA----RDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEI 272 K+ DFGL DG TR GT Y +PE +SS D+Y+ G++L E+ Sbjct: 176 KIGDFGLVTSLKNDGK-------RTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAEL 228 Query: 273 L 273 L Sbjct: 229 L 229 >4CFH-A nrPDB Length = 493 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 68/241 (28%), Positives = 111/241 (46%), Gaps = 24/241 (9%) Query: 45 EILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAV 104 E+L P+ ++ ++ ++ +G G FG V G TG +AV Sbjct: 13 EVLFQGPMAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVG---------KHELTGHKVAV 63 Query: 105 KKLNQEGFQGHR---EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENH 161 K LN++ + + EI L HP+++KL +V E++ G L ++ Sbjct: 64 KILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDY 123 Query: 162 LFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDF 221 + + G + L + G+ + H V++RD+K N+LLDA NAK++DF Sbjct: 124 ICKNGRLDEKESRRLFQQIL----SGVDYCHRH--MVVHRDLKPENVLLDAHMNAKIADF 177 Query: 222 GLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNA--RSDVYSFGVLLLEILSGKRAL 279 GL+ M D ++ T G+ YAAPE + SG L A D++S GV+L +L G Sbjct: 178 GLS--NMMSDGEFLRTSC-GSPNYAAPEVI-SGRLYAGPEVDIWSSGVILYALLCGTLPF 233 Query: 280 D 280 D Sbjct: 234 D 234 >5KZ7-A nrPDB Length = 346 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/224 (27%), Positives = 99/224 (44%), Gaps = 33/224 (14%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 N+R IG+G F V L LT + +I +LN Q + E+ + Sbjct: 34 NYRLLKTIGKGNFAKV---KLARHILTGKEVAVK-IIDKTQLNSSSLQ---KLFREVRIM 86 Query: 126 GQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRG--------AYFKPLPWFLR 177 L+HPN+VKL ++ LV E+ G + ++L G A F+ + Sbjct: 87 KVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI----- 141 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 + + H +++RD+KA N+LLDAD N K++DFG + + G+ Sbjct: 142 -------VSAVQYCHQK--FIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGN---KLD 189 Query: 238 RVMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 G+ YAAPE + + DV+S GV+L ++SG D Sbjct: 190 TFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 233 >3MN3-A nrPDB Length = 271 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 69/226 (30%), Positives = 108/226 (47%), Gaps = 37/226 (16%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 N++ +GEG FG K L T T K +I K L + QG E EI+YL Sbjct: 5 NYQIVKTLGEGSFG---KVKLAYHTTTGQKVALK-IINKKVLAKSDMQGRIE--REISYL 58 Query: 126 GQLSHPNLVKLIGYCLEDEHRLLVYEF---------MQKGSLENHLFRRGAYFKPLPWFL 176 L HP+++KL + ++V E+ +Q+ + RR +F Sbjct: 59 RLLRHPHIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQRDKMSEQEARR--------FFQ 110 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 ++ A++ + H K+++RD+K N+LLD N K++DFGL+ M D +++ Sbjct: 111 QIISAVE------YCHRH--KIVHRDLKPENLLLDEHLNVKIADFGLS--NIMTDGNFLK 160 Query: 237 TRVMGTYGYAAPEYMSSGHLNA--RSDVYSFGVLLLEILSGKRALD 280 T G+ YAAPE + SG L A DV+S GV+L +L + D Sbjct: 161 TSC-GSPNYAAPEVI-SGKLYAGPEVDVWSCGVILYVMLCRRLPFD 204 >1VZO-A nrPDB Length = 355 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 69/223 (30%), Positives = 103/223 (46%), Gaps = 22/223 (9%) Query: 61 KLATRNFRPDSVIGEGGFGCVF----KGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR 116 K+ NF V+G G +G VF D L K I K E + R Sbjct: 50 KVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTER 109 Query: 117 EWLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLPWF 175 + L I P LV L Y + E +L L+ +++ G L HL +R + + Sbjct: 110 QVLEHIR-----QSPFLVTL-HYAFQTETKLHLILDYINGGELFTHLSQRERFTEH---- 159 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 V + + LA H + +IYRDIK NILLD++ + L+DFGL+++ + D + Sbjct: 160 -EVQIYVGEIV-LALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEF-VADETER 216 Query: 236 STRVMGTYGYAAPEYM---SSGHLNARSDVYSFGVLLLEILSG 275 + GT Y AP+ + SGH A D +S GVL+ E+L+G Sbjct: 217 AYDFCGTIEYMAPDIVRGGDSGHDKA-VDWWSLGVLMYELLTG 258 >3MA6-A nrPDB Length = 298 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 61/224 (27%), Positives = 107/224 (47%), Gaps = 19/224 (8%) Query: 55 FTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG 114 F + + + ++ V+G+G FG V L + +T + VI+ +++ Q+ Sbjct: 22 FVQHSTAIFSDRYKGQRVLGKGSFGEVI---LCKDKITGQECAVK-VISKRQVKQK--TD 75 Query: 115 HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPW 174 L E+ L QL HPN++KL + + + LV E G L + + R K Sbjct: 76 KESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISR----KRFSE 131 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLARDGPMGD 231 + G+ ++H + K+++RD+K N+LL++ D N ++ DFGL+ + Sbjct: 132 VDAARIIRQVLSGITYMHKN--KIVHRDLKPENLLLESKSKDANIRIIDFGLS---THFE 186 Query: 232 LSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 S +GT Y APE + G + + DV+S GV+L +LSG Sbjct: 187 ASKKMKDKIGTAYYIAPEVL-HGTYDEKCDVWSTGVILYILLSG 229 >3OZ6-A nrPDB Length = 388 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 70/230 (30%), Positives = 110/230 (47%), Gaps = 44/230 (19%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH---REWLTEINYLGQLS 129 +G+G +G V+K +D T G V+AVKK+ + FQ + EI L +LS Sbjct: 17 LGKGAYGIVWKS-IDRRT--------GEVVAVKKI-FDAFQNSTDAQRTFREIMILTELS 66 Query: 130 -HPNLVKLIGYCLEDEHR--LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAK 186 H N+V L+ D R LV+++M+ + H R +P+ + V K Sbjct: 67 GHENIVNLLNVLRADNDRDVYLVFDYMET---DLHAVIRANILEPVH---KQYVVYQLIK 120 Query: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR----------DGPMG------ 230 + +LHS +++RD+K SNILL+A+ + K++DFGL+R + P+ Sbjct: 121 VIKYLHSG--GLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTE 178 Query: 231 ---DLSYVSTRVMGTYGYAAPEY-MSSGHLNARSDVYSFGVLLLEILSGK 276 D + T + T Y APE + S D++S G +L EIL GK Sbjct: 179 NFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGK 228 >4KS7-A nrPDB Length = 292 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 65/243 (26%), Positives = 110/243 (45%), Gaps = 39/243 (16%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IGEG G V + +G +AVK ++ Q E+ + H N Sbjct: 31 IGEGSTGIVCLA---------REKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFN 81 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN------VALDAAK 186 +V++ L E ++ EF+Q G+L + + + +R+N V + Sbjct: 82 VVEMYKSYLVGEELWVLMEFLQGGALTDIVSQ-----------VRLNEEQIATVCEAVLQ 130 Query: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFG----LARDGPMGDLSYVSTRVMGT 242 LA+LH+ VI+RDIK+ +ILL D KLSDFG +++D P ++GT Sbjct: 131 ALAYLHAQ--GVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPK------RKSLVGT 182 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE-ENLVDWARPYLTSK 301 + APE +S D++S G++++E++ G+ + P + + L D P L + Sbjct: 183 PYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNS 242 Query: 302 RKV 304 KV Sbjct: 243 HKV 245 >2HAK-A nrPDB Length = 328 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 61/224 (27%), Positives = 99/224 (44%), Gaps = 33/224 (14%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 N+R IG+G F V L LT + +I +LN Q + E+ + Sbjct: 16 NYRLQKTIGKGNFAKV---KLARHVLTGREVAVK-IIDKTQLNPTSLQ---KLFREVRIM 68 Query: 126 GQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRG--------AYFKPLPWFLR 177 L+HPN+VKL ++ LV E+ G + ++L G A F+ + Sbjct: 69 KILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI----- 123 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 + + H +++RD+KA N+LLD D N K++DFG + + +G+ Sbjct: 124 -------VSAVQYCHQK--YIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGN---KLD 171 Query: 238 RVMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 G+ YAAPE + + DV+S GV+L ++SG D Sbjct: 172 TFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 215 >5GRN-A nrPDB Length = 356 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 81/314 (25%), Positives = 132/314 (42%), Gaps = 63/314 (20%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL-TEINYLGQLS- 129 V+G G FG V +G L+ ++P + +AVK L ++ L +E+ + L Sbjct: 53 VLGSGAFGKVVEG--TAYGLSRSQPV--MKVAVKMLKPTARSSEKQALMSELKIMTHLGP 108 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF-------------------- 169 H N+V L+G C + ++ E+ G L N+L + F Sbjct: 109 HLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDD 168 Query: 170 --KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG 227 + L ++ A+G+ FL S ++RD+ A N+LL K+ DFGLARD Sbjct: 169 NSEGLTLLDLLSFTYQVARGMEFLASK--NCVHRDLAARNVLLAQGKIVKICDFGLARD- 225 Query: 228 PMGDLSYVST-RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK 286 M D +YVS + APE + SDV+S+G+LL EI S Sbjct: 226 IMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLG---------- 275 Query: 287 EENLVDWARPYLTSKRKVLLIVD----NRLDTQYL---PEEAV-RMASVAVQCLSFEPKS 338 PY ++VD N++ + Y P+ A + + V+C + EP+ Sbjct: 276 -------GTPYPG------MMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEK 322 Query: 339 RPTMDQVVRALQQL 352 RP+ + ++ L Sbjct: 323 RPSFYHLSEIVENL 336 >4M69-B nrPDB Length = 283 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 59/249 (23%), Positives = 117/249 (46%), Gaps = 36/249 (14%) Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHR----LLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 EI + + PN++++ G C++ + +V E+ + G+L L R K L + Sbjct: 58 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDRE----KDLTMSV 113 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 R + L AA+GL LH + ++R+I +S+ L+ Y KL+ F L++ + S Sbjct: 114 RSLLVLRAARGLYRLHHS--ETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKS 171 Query: 237 TRVMGTYG--YAAPEYMSSGHL--NARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVD 292 T+ + Y +PE + + + ++++YSFG++L EI +GK + Sbjct: 172 TKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEG----------- 220 Query: 293 WARPYLTSKRKVLLIVDNRLDT---QYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRAL 349 SK+ L+ +++ Q PE + + +C + EP RP++D ++ L Sbjct: 221 -----CDSKKIRELVAEDKKQEPVGQDCPE---LLREIINECRAHEPSQRPSVDGILERL 272 Query: 350 QQLQDNLGK 358 ++++ K Sbjct: 273 SAVEESTDK 281 >2QNJ-A nrPDB Length = 328 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 62/216 (28%), Positives = 102/216 (47%), Gaps = 17/216 (7%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 N+R IG+G F V L LT + +I +LN Q + E+ + Sbjct: 13 NYRLLKTIGKGNFAKV---KLARHILTGREVAIK-IIDKTQLNPTSLQ---KLFREVRIM 65 Query: 126 GQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 L+HPN+VKL ++ L+ E+ G + ++L G K + + A Sbjct: 66 KILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR-MKEKEARSKFRQIVSAV 124 Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGY 245 + + H ++++RD+KA N+LLDAD N K++DFG + + +G + T G+ Y Sbjct: 125 Q---YCHQK--RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVG--GKLDT-FCGSPPY 176 Query: 246 AAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 AAPE + + DV+S GV+L ++SG D Sbjct: 177 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFD 212 >3LZB-A nrPDB Length = 327 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 59/233 (25%), Positives = 113/233 (48%), Gaps = 24/233 (10%) Query: 62 LATRNFRPDSVIGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQE-GFQGHREWL 119 L F+ V+G G FG V+KG W+ P + +A+K+L + + ++E L Sbjct: 12 LKETEFKKIKVLGSGAFGTVYKGLWI------PEGEKVKIPVAIKELREATSPKANKEIL 65 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR----GAYFKPLPWF 175 E + + +P++ +L+G CL +L+ + M G L +++ G+ + Sbjct: 66 DEAYVMASVDNPHVCRLLGICLTSTVQLIT-QLMPFGCLLDYVREHKDNIGSQY------ 118 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 +N + AKG+ +L ++++RD+ A N+L+ + K++DFGLA+ + Y Sbjct: 119 -LLNWCVQIAKGMNYLEDR--RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYH 175 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKE 287 + + A E + +SDV+S+GV + E+++ G + D PA E Sbjct: 176 AEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYD-GIPASE 227 >3DB8-A nrPDB Length = 317 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 49/161 (30%), Positives = 83/161 (51%), Gaps = 16/161 (9%) Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLP-WFLRV 178 TEI L +P++V G+ +D+ +V E ++ SL RR A +P +F+R Sbjct: 91 TEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQ 150 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR 238 + +G+ +LH++ +VI+RD+K N+ L+ D + K+ DFGLA + + R Sbjct: 151 TI-----QGVQYLHNN--RVIHRDLKLGNLFLNDDMDVKIGDFGLA-----TKIEFDGER 198 Query: 239 ---VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 + GT Y APE + + D++S G +L +L GK Sbjct: 199 KKDLCGTPNYIAPEVLCKKGHSFEVDIWSLGCILYTLLVGK 239 >5GNK-A nrPDB Length = 297 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 59/233 (25%), Positives = 114/233 (48%), Gaps = 24/233 (10%) Query: 62 LATRNFRPDSVIGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQE-GFQGHREWL 119 L F+ V+G G FG V+KG W+ P + +A+K+L + + ++E L Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWI------PEGEKVKIPVAIKELREATSPKANKEIL 69 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR----GAYFKPLPWF 175 E + + +P++ +L+G CL +L++ + M G L +++ G+ + Sbjct: 70 DEAYVMASVDNPHVCRLLGICLTSTVQLIM-QLMPFGCLLDYVREHKDNIGSQY------ 122 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 +N + AKG+ +L ++++RD+ A N+L+ + K++DFGLA+ + Y Sbjct: 123 -LLNWCVQIAKGMNYLEDR--RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYH 179 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKE 287 + + A E + +SDV+S+GV + E+++ G + D PA E Sbjct: 180 AEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYD-GIPASE 231 >3ALO-A nrPDB Length = 327 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 62/210 (29%), Positives = 100/210 (47%), Gaps = 19/210 (9%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE-GFQGHREWLTEINYLGQLSH- 130 IG G +G V K KP +G ++AVK++ + ++ L +++ + + S Sbjct: 30 IGRGAYGSVNK--------MVHKP-SGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDC 80 Query: 131 PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAF 190 P +V+ G + + E M + + + +P + + L K L Sbjct: 81 PYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNH 140 Query: 191 LHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEY 250 L + +K+I+RDIK SNILLD N KL DFG++ G + D S TR G Y APE Sbjct: 141 LKEN-LKIIHRDIKPSNILLDRSGNIKLCDFGIS--GQLVD-SIAKTRDAGCRPYMAPER 196 Query: 251 M----SSGHLNARSDVYSFGVLLLEILSGK 276 + S + RSDV+S G+ L E+ +G+ Sbjct: 197 IDPSASRQGYDVRSDVWSLGITLYELATGR 226 >2BRG-A nrPDB Length = 297 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 58/187 (31%), Positives = 89/187 (47%), Gaps = 10/187 (5%) Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 EI L+H N+VK G+ E + L E+ G L + + P P R Sbjct: 55 EICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRI--EPDIGMPEPDAQRFFH 112 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 L A G+ +LH + + +RDIK N+LLD N K+SDFGLA + + ++ Sbjct: 113 QLMA--GVVYLHG--IGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMC 168 Query: 241 GTYGYAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKRALDHNRPAKEENLVDW--ARPY 297 GT Y APE + +A DV+S G++L +L+G+ D + +E DW + Y Sbjct: 169 GTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQE-YSDWKEKKTY 227 Query: 298 LTSKRKV 304 L +K+ Sbjct: 228 LNPWKKI 234 >4EWQ-A nrPDB Length = 383 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 100/215 (46%), Gaps = 31/215 (14%) Query: 71 SVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN---QEGFQGHREWLTEINYLGQ 127 S +G G +G V + TGL +AVKKL+ Q R + E+ L Sbjct: 51 SPVGSGAYGSVCAAF---------DTKTGLRVAVKKLSRPFQSIIHAKRTY-RELRLLKH 100 Query: 128 LSHPNLVKLI-----GYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 + H N++ L+ LE+ + + + + L N++ + FL + Sbjct: 101 MKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQIL- 158 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 +GL ++HS +I+RD+K SN+ ++ D K+ DFGLAR YV+TR Sbjct: 159 ---RGLKYIHS--ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATR---- 209 Query: 243 YGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSGK 276 Y APE M + H N D++S G ++ E+L+G+ Sbjct: 210 -WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGR 243 >1UA2-A nrPDB Length = 346 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 64/226 (28%), Positives = 105/226 (46%), Gaps = 33/226 (14%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN----QEGFQG 114 ++K + + +GEG F V+K T ++A+KK+ E G Sbjct: 4 DVKSRAKRYEKLDFLGEGQFATVYKA---------RDKNTNQIVAIKKIKLGHRSEAKDG 54 Query: 115 -HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLE-----NHLFRRGAY 168 +R L EI L +LSHPN++ L+ + LV++FM+ LE N L ++ Sbjct: 55 INRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTPSH 113 Query: 169 FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGP 228 K L +GL +LH +++RD+K +N+LLD + KL+DFGLA+ Sbjct: 114 IK--------AYMLMTLQGLEYLHQH--WILHRDLKPNNLLLDENGVLKLADFGLAKS-- 161 Query: 229 MGDLSYVSTRVMGTYGYAAPEYMSSGHL-NARSDVYSFGVLLLEIL 273 G + T + T Y APE + + D+++ G +L E+L Sbjct: 162 FGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL 207 >5C01-A nrPDB Length = 342 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 75/279 (26%), Positives = 128/279 (45%), Gaps = 43/279 (15%) Query: 87 DESTLTPTKP-GTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEH 145 DE L P + G L + +K L+ + + + Q+SH +L + G C+ Sbjct: 94 DEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPE 153 Query: 146 RLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKA 205 ++V E+++ G L+ L R + P+ W ++ VA A L++L + +++ ++ Sbjct: 154 NIMVTEYVEHGPLDVWLRRERGHV-PMAW--KMVVAQQLASALSYLENK--NLVHGNVCG 208 Query: 206 SNILLD----ADYNA---KLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSG--HL 256 NILL A+ + KLSD G+ +G LS RV + APE + G L Sbjct: 209 RNILLARLGLAEGTSPFIKLSDPGVG----LGALSR-EERVE-RIPWLAPECLPGGANSL 262 Query: 257 NARSDVYSFGVLLLEI-LSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQ 315 + D + FG LLEI G+ L P+++E+ Y R Sbjct: 263 STAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHF------YQRQHR------------- 303 Query: 316 YLPEEAV-RMASVAVQCLSFEPKSRPTMDQVVRALQQLQ 353 LPE + ++A++ QCL++EP RP+ ++R L +LQ Sbjct: 304 -LPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQ 341 >4MWI-A nrPDB Length = 294 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 58/239 (24%), Positives = 106/239 (44%), Gaps = 32/239 (13%) Query: 121 EINYLGQLSHPNLVKLIGYCLEDE----HRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 EI + + PN++++ G C+++ +V E+ + G+L L R K L Sbjct: 73 EIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDRE----KDLTLGK 128 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG---PMGDLS 233 R+ + L AA+GL LH ++ I++SN L+ Y KL+ F L + +G Sbjct: 129 RMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTR 188 Query: 234 YVSTRVMGTYGYAAPEYMSSG--HLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 + RV T Y +P+ + + +S++YSFG++L EI +G K LV Sbjct: 189 EKTDRVKST-AYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLV 247 Query: 292 DWARPYLTSKRKVLLIVDNRLDTQYLPEEA-VRMASVAVQCLSFEPKSRPTMDQVVRAL 349 R + L E+ + + +C + +P RP++D++++ L Sbjct: 248 AVKR-----------------QQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKL 289 >2YZA-A nrPDB Length = 276 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 81/281 (28%), Positives = 125/281 (44%), Gaps = 48/281 (17%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR---EWLTEINYLGQLS 129 +G G FG V G E LT K +AVK LN++ + + EI L Sbjct: 19 LGVGTFGKVKIG---EHQLTGHK------VAVKILNRQKIRSLDVVGKIKREIQNLKLFR 69 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAY--FKPLPWFLRVNVALDAAKG 187 HP+++KL +V E++ G L +++ + G + F ++ A+D Sbjct: 70 HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVD---- 125 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAA 247 + H V++RD+K N+LLDA NAK++DFGL+ M D ++ G+ YAA Sbjct: 126 --YCHRH--MVVHRDLKPENVLLDAHMNAKIADFGLS--NMMSDGEFLRDSC-GSPNYAA 178 Query: 248 PEYMSSGHLNA--RSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVL 305 PE + SG L A D++S GV+L +L G D D P L K Sbjct: 179 PEVI-SGRLYAGPEVDIWSCGVILYALLCGTLPFD-----------DEHVPTLFKK---- 222 Query: 306 LIVDNRLDTQYLPEEAVR-MASVAVQCLSFEPKSRPTMDQV 345 R Y+PE R +A++ + L +P R T+ + Sbjct: 223 ----IRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 259 >2QLU-A nrPDB Length = 314 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 70/228 (30%), Positives = 106/228 (46%), Gaps = 45/228 (19%) Query: 76 GGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL---NQEGFQGHREWLTEINYLGQLSHPN 132 G FGCV+K L +AVK +++ +Q RE I + H N Sbjct: 26 GRFGCVWKAQLMND-----------FVAVKIFPLQDKQSWQSERE----IFSTPGMKHEN 70 Query: 133 LVKLI-----GYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 L++ I G LE E L+ F KGSL ++L +G + W +VA ++G Sbjct: 71 LLQFIAAEKRGSNLEVE-LWLITAFHDKGSLTDYL--KGNI---ITWNELCHVAETMSRG 124 Query: 188 LAFLHSD---------PVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR 238 L++LH D + +RD K+ N+LL +D A L+DFGLA G + Sbjct: 125 LSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHG 184 Query: 239 VMGTYGYAAPEYMSSGHLN------ARSDVYSFGVLLLEILSGKRALD 280 +GT Y APE + G +N R D+Y+ G++L E++S +A D Sbjct: 185 QVGTRRYMAPEVL-EGAINFQRDAFLRIDMYAMGLVLWELVSRCKAAD 231 >4IDT-A nrPDB Length = 356 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 72/252 (28%), Positives = 113/252 (44%), Gaps = 32/252 (12%) Query: 31 KSSSTVAAAQKTEGEILSST--PVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDE 88 +S + EG +L+ PV E+ AT R +G G FG V + +++ Sbjct: 42 RSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLR----LGRGSFGEVHR--MED 95 Query: 89 STLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLL 148 TG AVKK+ E F+ E+ L+ P +V L G E + Sbjct: 96 KQ-------TGFQCAVKKVRLEVFRAE-----ELMACAGLTSPRIVPLYGAVREGPWVNI 143 Query: 149 VYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNI 208 E ++ GSL + +G LP + A +GL +LHS ++++ D+KA N+ Sbjct: 144 FMELLEGGSLGQLVKEQGC----LPEDRALYYLGQALEGLEYLHSR--RILHGDVKADNV 197 Query: 209 LLDAD-YNAKLSDFG----LARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVY 263 LL +D +A L DFG L DG DL + GT + APE + +A+ DV+ Sbjct: 198 LLSSDGSHAALCDFGHAVCLQPDGLGKDL-LTGDYIPGTETHMAPEVVLGRSCDAKVDVW 256 Query: 264 SFGVLLLEILSG 275 S ++L +L+G Sbjct: 257 SSCCMMLHMLNG 268 >5NGU-A nrPDB Length = 381 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 93/334 (27%), Positives = 143/334 (42%), Gaps = 70/334 (20%) Query: 71 SVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-REWLTEINYLGQLS 129 S IGEG +G V + L + +A+KK++ Q + + L EI L + Sbjct: 48 SYIGEGAYGMVCSAY---DNLNKVR------VAIKKISPFEHQTYCQRTLREIKILLRFR 98 Query: 130 HPNLVKLIG-------------YCLEDEHRLLVYEFMQKGSLEN-HLFRRGAYFKPLPWF 175 H N++ + Y ++D +Y+ ++ L N H+ YF L Sbjct: 99 HENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHI----CYF--LYQI 152 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG-PMGDLSY 234 LR GL ++HS V++RD+K SN+LL+ + K+ DFGLAR P D + Sbjct: 153 LR---------GLKYIHS--ANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG 201 Query: 235 VSTRVMGTYGYAAPEYMSSGHLNARS-DVYSFGVLLLEILS------GKRALDH------ 281 T + T Y APE M + +S D++S G +L E+LS GK LD Sbjct: 202 FLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 261 Query: 282 --NRPAKEE-----NLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSF 334 P++E+ NL AR YL S + NRL P + + + L+F Sbjct: 262 ILGSPSQEDLNCIINLK--ARNYLLSLPHKNKVPWNRL----FPNADSKALDLLDKMLTF 315 Query: 335 EPKSRPTMDQVVRA--LQQLQDNLGKPSQTNPVK 366 P R ++Q + L+Q D +P P K Sbjct: 316 NPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFK 349 >3ZDU-A nrPDB Length = 325 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 60/207 (28%), Positives = 94/207 (45%), Gaps = 23/207 (11%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG-HREWLTEINYLGQLSHP 131 +GEG +G V K TG ++A+K + Q ++ + EI +L Q H Sbjct: 11 VGEGSYGTVMKC---------KHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHE 61 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSL-ENHLFRRGAYFKPLPWFLRVNVALDAAKGLAF 190 NLV LI + + LV+EF+ L E + G K L +L + + + Sbjct: 62 NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYL-----FQILRAIDY 116 Query: 191 LHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD-GPMGDLSYVSTRVMGTYGYAAPE 249 LHS+ +I+RDIK NIL+ KL DFG AR GD + + T Y APE Sbjct: 117 LHSN--NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGD---IYDDEVATRWYRAPE 171 Query: 250 -YMSSGHLNARSDVYSFGVLLLEILSG 275 + D+++ G +++E+ +G Sbjct: 172 LVLKDTSYGKPVDIWALGCMIIEMATG 198 >3OHT-A nrPDB Length = 389 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 62/215 (28%), Positives = 101/215 (46%), Gaps = 31/215 (14%) Query: 71 SVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN---QEGFQGHREWLTEINYLGQ 127 S +G G +G V + +S GL IAVKKL+ Q R + E+ L Sbjct: 57 SPVGSGAYGSVCSSYDVKS---------GLKIAVKKLSRPFQSIIHAKRTY-RELRLLKH 106 Query: 128 LSHPNLVKLI-----GYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 + H N++ L+ LE+ + + + + L N++ + FL + Sbjct: 107 MKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADL-NNIVKCQKLTDDHVQFLIYQIL- 164 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 +GL ++HS +I+RD+K SN+ ++ D K+ DFGLAR YV+TR Sbjct: 165 ---RGLKYIHS--ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATR---- 215 Query: 243 YGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSGK 276 Y APE M + H N D++S G ++ E+L+G+ Sbjct: 216 -WYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGR 249 >4BTF-A nrPDB Length = 469 Score = 68.2 bits (165), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 59/249 (23%), Positives = 117/249 (46%), Gaps = 36/249 (14%) Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHR----LLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 EI + + PN++++ G C++ + +V E+ + G+L L R K L + Sbjct: 244 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDRE----KDLTMSV 299 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 R + L AA+GL LH + ++R+I +S+ L+ Y KL+ F L++ + S Sbjct: 300 RSLLVLRAARGLYRLHHS--ETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKS 357 Query: 237 TRVMGTYG--YAAPEYMSSGHL--NARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVD 292 T+ + Y +PE + + + ++++YSFG++L EI +GK + Sbjct: 358 TKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEG----------- 406 Query: 293 WARPYLTSKRKVLLIVDNRLDT---QYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRAL 349 SK+ L+ +++ Q PE + + +C + EP RP++D ++ L Sbjct: 407 -----CDSKKIRELVAEDKKQEPVGQDCPE---LLREIINECRAHEPSQRPSVDGILERL 458 Query: 350 QQLQDNLGK 358 ++++ K Sbjct: 459 SAVEESTDK 467 >2OU7-A nrPDB Length = 335 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 77/281 (27%), Positives = 126/281 (44%), Gaps = 46/281 (16%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT-EINYLGQLSHP 131 +G+GGF F E + TK I K L + Q RE ++ EI+ L+H Sbjct: 49 LGKGGFAKCF-----EISDADTKEVFAGKIVPKSLLLKPHQ--REKMSMEISIHRSLAHQ 101 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 ++V G+ +++ +V E ++ SL RR A +P + + L G +L Sbjct: 102 HVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVL----GCQYL 157 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR---VMGTYGYAAP 248 H + +VI+RD+K N+ L+ D K+ DFGLA + Y R + GT Y AP Sbjct: 158 HRN--RVIHRDLKLGNLFLNEDLEVKIGDFGLA-----TKVEYDGERKKVLCGTPNYIAP 210 Query: 249 EYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS--KRKVLL 306 E +S + DV+S G ++ +L GK P+ TS K L Sbjct: 211 EVLSKKGHSFEVDVWSIGCIMYTLLVGK------------------PPFETSCLKETYLR 252 Query: 307 IVDNRLDTQYLPEEAVRMASVAVQ-CLSFEPKSRPTMDQVV 346 I N +P+ +A+ +Q L +P +RPT+++++ Sbjct: 253 IKKNEYS---IPKHINPVAASLIQKMLQTDPTARPTINELL 290 >1G3N-A nrPDB Length = 326 Score = 67.8 bits (164), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 68/226 (30%), Positives = 108/226 (47%), Gaps = 30/226 (13%) Query: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN-QEGFQGH-----R 116 A + + + IGEG +G VFK K G G +A+K++ Q G +G R Sbjct: 9 ADQQYECVAEIGEGAYGKVFKA-------RDLKNG-GRFVALKRVRVQTGEEGMPLSTIR 60 Query: 117 EWLTEINYLGQLSHPNLVKLIGYCL----EDEHRL-LVYEFMQKGSLENHLFRRGAYFKP 171 E + + +L HPN+V+L C + E +L LV+E + + L +L + +P Sbjct: 61 E-VAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVP---EP 115 Query: 172 -LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMG 230 +P ++ +GL FLHS +V++RD+K NIL+ + KL+DFGLAR + Sbjct: 116 GVPTETIKDMMFQLLRGLDFLHSH--RVVHRDLKPQNILVTSSGQIKLADFGLAR---IY 170 Query: 231 DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 T V+ T Y APE + D++S G + E+ K Sbjct: 171 SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRK 216 >3E3P-A nrPDB Length = 360 Score = 67.8 bits (164), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 64/221 (28%), Positives = 106/221 (47%), Gaps = 27/221 (12%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLG 126 F+ + + G+G FG V G + TG+ +A+KK+ Q+ +RE L + L Sbjct: 25 FQVERMAGQGTFGTVQLG---------KEKSTGMSVAIKKVIQDPRFRNRE-LQIMQDLA 74 Query: 127 QLSHPNLVKLIGY--CLEDEHRLLVYEFMQKGSLENHLFR--RGAYFK---PLPWFLRVN 179 L HPN+V+L Y L + R +Y + + + L R R Y + P P ++V Sbjct: 75 VLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPILIKV- 133 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILL-DADYNAKLSDFGLAR--DGPMGDLSYVS 236 + + LH V V +RDIK N+L+ +AD KL DFG A+ +++Y+ Sbjct: 134 FLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYIC 193 Query: 237 TRVMGTYGYAAPEYM-SSGHLNARSDVYSFGVLLLEILSGK 276 +R Y APE + + H D++S G + E++ G+ Sbjct: 194 SRY-----YRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGE 229 >5USZ-A nrPDB Length = 289 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 76/293 (25%), Positives = 129/293 (44%), Gaps = 48/293 (16%) Query: 73 IGEGGFGCVFKGWL----DESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQL 128 +G+G F +FKG D L T+ + +K L++ + + + +L Sbjct: 16 LGQGTFTKIFKGVRREVGDYGQLHETE------VLLKVLDKAHRNYSESFFEAASMMSKL 69 Query: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 SH +LV G C+ + +LV EF++ GSL+ +L + L W ++ VA A + Sbjct: 70 SHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINIL-W--KLEVAKQLAAAM 126 Query: 189 AFLHSDPVKVIYRDIKASNILLDADYN--------AKLSDFGLARDGPMGDLSYVSTRVM 240 FL + +I+ ++ A NILL + + KLSD G++ D+ + R+ Sbjct: 127 HFLEEN--TLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDI--LQERI- 181 Query: 241 GTYGYAAPEYMSS-GHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLT 299 + PE + + +LN +D +SFG L EI SG D L Sbjct: 182 ---PWVPPECIENPKNLNLATDKWSFGTTLWEICSGG---------------DKPLSALD 223 Query: 300 SKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 S+RK+ D Q +A +A++ C+ +EP RP+ ++R L L Sbjct: 224 SQRKLQFYEDRH---QLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSL 273 >4J52-A nrPDB Length = 293 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 77/281 (27%), Positives = 126/281 (44%), Gaps = 46/281 (16%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT-EINYLGQLSHP 131 +G+GGF F E + TK I K L + Q RE ++ EI+ L+H Sbjct: 22 LGKGGFAKCF-----EISDADTKEVFAGKIVPKSLLLKPHQ--REKMSMEISIHRSLAHQ 74 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 ++V G+ +++ +V E ++ SL RR A +P + + L G +L Sbjct: 75 HVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVL----GCQYL 130 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR---VMGTYGYAAP 248 H + +VI+RD+K N+ L+ D K+ DFGLA + Y R + GT Y AP Sbjct: 131 HRN--RVIHRDLKLGNLFLNEDLEVKIGDFGLA-----TKVEYDGERKKVLCGTPNYIAP 183 Query: 249 EYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS--KRKVLL 306 E +S + DV+S G ++ +L GK P+ TS K L Sbjct: 184 EVLSKKGHSFEVDVWSIGCIMYTLLVGK------------------PPFETSCLKETYLR 225 Query: 307 IVDNRLDTQYLPEEAVRMASVAVQ-CLSFEPKSRPTMDQVV 346 I N +P+ +A+ +Q L +P +RPT+++++ Sbjct: 226 IKKNEYS---IPKHINPVAASLIQKMLQTDPTARPTINELL 263 >1PY5-A nrPDB Length = 326 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 82/313 (26%), Positives = 132/313 (42%), Gaps = 51/313 (16%) Query: 73 IGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL--TEINYLGQLS 129 IG+G FG V++G W E +AVK + + R W EI L Sbjct: 37 IGKGRFGEVWRGKWRGEE------------VAVKIFSS---REERSWFREAEIYQTVMLR 81 Query: 130 HPNLVKLIGYCLEDE----HRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 H N++ I +D LV ++ + GSL ++L R + + + +AL A Sbjct: 82 HENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGM-----IKLALSTA 136 Query: 186 KGLAFLHSDPV------KVIYRDIKASNILLDADYNAKLSDFGLA--RDGPMGDLSYVST 237 GLA LH + V + +RD+K+ NIL+ + ++D GLA D + Sbjct: 137 SGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPN 196 Query: 238 RVMGTYGYAAPEYMSSG----HLNA--RSDVYSFGVLLLEILS----GKRALDHNRPAKE 287 +GT Y APE + H + R+D+Y+ G++ EI G D+ P + Sbjct: 197 HRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYD 256 Query: 288 ENLVDWARPYLTSKRKVLLIVDNR--LDTQYLPEEAVR-MASVAVQCLSFEPKSRPTMDQ 344 D P + RKV+ R + ++ EA+R MA + +C +R T + Sbjct: 257 LVPSD---PSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALR 313 Query: 345 VVRALQQLQDNLG 357 + + L QL G Sbjct: 314 IKKTLSQLSQQEG 326 >3D2K-A nrPDB Length = 272 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 54/206 (26%), Positives = 93/206 (45%), Gaps = 22/206 (10%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG---HREWLTEINYLGQLS 129 +G+G FG V+ +S ++A+K L + + + E+ L Sbjct: 20 LGKGKFGNVYLARERQSKF---------ILALKVLFKTQLEKAGVEHQLRREVEIQSHLR 70 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 HPN+++L GY + L+ E+ G++ L + + + + A L+ Sbjct: 71 HPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRT----ATYITELANALS 126 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPE 249 + HS +VI+RDIK N+LL ++ K++DFG + P S T + GT Y PE Sbjct: 127 YCHSK--RVIHRDIKPENLLLGSNGELKIADFGWSVHAP----SSRRTTLCGTLDYLPPE 180 Query: 250 YMSSGHLNARSDVYSFGVLLLEILSG 275 + + + D++S GVL E L G Sbjct: 181 MIEGRMHDEKVDLWSLGVLCYEFLVG 206 >4D28-A nrPDB Length = 446 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 66/216 (30%), Positives = 102/216 (47%), Gaps = 39/216 (18%) Query: 73 IGEGGFGCV-FKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR---EWLTEINYLGQL 128 IGEG F V F D TG +A+K + + +R + EI+ + + Sbjct: 17 IGEGTFAKVKFARNTD----------TGDNVAIKIMAKSTILKNRMVDQIKREISIMKIV 66 Query: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRG--------AYFKPLPWFLRVNV 180 HPN+V+L +V EF+ G L + + +G YF+ L Sbjct: 67 RHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQQL-------- 118 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 +DA +A HS V +RD+K N+LLD + N K+SDFGL+ P + ++ Sbjct: 119 -VDA---VAHCHSK--GVYHRDLKPENLLLDTNGNLKVSDFGLSA-LPQEGVELLND-TC 170 Query: 241 GTYGYAAPEYMS-SGHLNARSDVYSFGVLLLEILSG 275 GT Y APE +S G+ + +D++S GV+L IL+G Sbjct: 171 GTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAG 206 >3GC9-A nrPDB Length = 370 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 63/229 (27%), Positives = 104/229 (45%), Gaps = 32/229 (13%) Query: 56 TFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQ 113 T E+ + RP +G G +G V + ++ L +AVKKL++ + Sbjct: 22 TVWEVPQRLQGLRP---VGSGAYGSVCSAY--DARLRQK-------VAVKKLSRPFQSLI 69 Query: 114 GHREWLTEINYLGQLSHPNLVKLI-----GYCLEDEHRLLVYEFMQKGSLENHLFRRGAY 168 R E+ L L H N++ L+ +ED + + + L N++ + A Sbjct: 70 HARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADL-NNIVKSQAL 128 Query: 169 FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGP 228 FL + +GL ++HS +I+RD+K SN+ ++ D ++ DFGLAR Sbjct: 129 SDEHVQFLVYQLL----RGLKYIHS--AGIIHRDLKPSNVAVNEDSELRILDFGLARQAD 182 Query: 229 MGDLSYVSTRVMGTYGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSGK 276 YV+TR Y APE M + H N D++S G ++ E+L GK Sbjct: 183 EEMTGYVATR-----WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGK 226 >2W96-B nrPDB Length = 306 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 82/324 (25%), Positives = 137/324 (42%), Gaps = 46/324 (14%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN----QEGF--QGH 115 +AT + P + IG G +G V+K P +G +A+K + +EG Sbjct: 1 MATSRYEPVAEIGVGAYGTVYKA---------RDPHSGHFVALKSVRVPNGEEGLPISTV 51 Query: 116 REWLTEINYLGQLSHPNLVKLIGYC----LEDEHRL-LVYEFMQKGSLENHLFRRGAYFK 170 RE + + L HPN+V+L+ C + E ++ LV+E + + L +L + A Sbjct: 52 RE-VALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDK--APPP 107 Query: 171 PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMG 230 LP ++ +GL FLH++ +++RD+K NIL+ + KL+DFGLAR + Sbjct: 108 GLPAETIKDLMRQFLRGLDFLHAN--CIVHRDLKPENILVTSGGTVKLADFGLAR---IY 162 Query: 231 DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENL 290 V+ T Y APE + D++S G + E+ K N A + Sbjct: 163 SYQMALDPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGK 222 Query: 291 V----------DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP 340 + DW R ++ R R +PE A + ++ L+F P R Sbjct: 223 IFDLIGLPPEDDWPRD-VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKR- 280 Query: 341 TMDQVVRALQQLQDNLGKPSQTNP 364 + A + LQ + + NP Sbjct: 281 -----ISAFRALQHSYLHKDEGNP 299 >3SOC-A nrPDB Length = 322 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 67/230 (29%), Positives = 100/230 (43%), Gaps = 40/230 (17%) Query: 71 SVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTE--INYLGQL 128 V G FGCV+K L +AVK Q + W E + L + Sbjct: 30 EVKARGRFGCVWKAQL-----------LNEYVAVKIFP---IQDKQSWQNEYEVYSLPGM 75 Query: 129 SHPNLVKLIGY----CLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 H N+++ IG D L+ F +KGSL + L + W ++A Sbjct: 76 KHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFL-----KANVVSWNELCHIAETM 130 Query: 185 AKGLAFLHSD--------PVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 A+GLA+LH D + +RDIK+ N+LL + A ++DFGLA G + + Sbjct: 131 ARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDT 190 Query: 237 TRVMGTYGYAAPEYMSSGHLN------ARSDVYSFGVLLLEILSGKRALD 280 +GT Y APE + G +N R D+Y+ G++L E+ S A D Sbjct: 191 HGQVGTRRYMAPEVL-EGAINFQRDAFLRIDMYAMGLVLWELASRCTAAD 239 >4WOV-A nrPDB Length = 317 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 74/278 (26%), Positives = 127/278 (45%), Gaps = 43/278 (15%) Query: 87 DESTLTPTKP-GTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEH 145 DE L P + G L + +K L+ + + + Q+SH +L + G C+ Sbjct: 71 DEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPE 130 Query: 146 RLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKA 205 ++V E+++ G L+ L R + P+ W ++ VA A L++L + +++ ++ Sbjct: 131 NIMVTEYVEHGPLDVWLRRERGHV-PMAW--KMVVAQQLASALSYLENK--NLVHGNVCG 185 Query: 206 SNILLD----ADYNA---KLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSG--HL 256 NILL A+ + KLSD G+ +G LS RV + APE + G L Sbjct: 186 RNILLARLGLAEGTSPFIKLSDPGVG----LGALSR-EERVE-RIPWLAPECLPGGANSL 239 Query: 257 NARSDVYSFGVLLLEI-LSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQ 315 + D + FG LLEI G+ L P+++E+ Y R Sbjct: 240 STAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHF------YQRQHR------------- 280 Query: 316 YLPEEAV-RMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 LPE + ++A++ QCL++EP RP+ ++R L +L Sbjct: 281 -LPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRL 317 >5B2L-A nrPDB Length = 324 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/187 (31%), Positives = 97/187 (51%), Gaps = 17/187 (9%) Query: 98 TGLVIAVKKLNQEGF-QGHREWLTEINYLGQLSH--PNLVKLIGYCLEDEHRLLVYEFMQ 154 TG VIAVK++ + G + ++ L +++ + + SH P +V+ G + + + E M Sbjct: 41 TGHVIAVKQMRRSGNKEENKRILMDLDVVLK-SHDCPYIVQCFGTFITNTDVFIAMELM- 98 Query: 155 KGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY 214 G+ L +R P+P + + + K L +L + VI+RD+K SNILLD Sbjct: 99 -GTSAEKLKKRMQ--GPIPERILGKMTVAIVKALYYL-KEKHGVIHRDVKPSNILLDERG 154 Query: 215 NAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM-----SSGHLNARSDVYSFGVLL 269 KL DFG++ G + D S TR G Y APE + + + R+DV+S G+ L Sbjct: 155 QIKLCDFGIS--GRLVD-SKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISL 211 Query: 270 LEILSGK 276 +E+ +G+ Sbjct: 212 VELATGQ 218 >2JC6-A nrPDB Length = 334 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 57/196 (29%), Positives = 92/196 (46%), Gaps = 14/196 (7%) Query: 84 GWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL-TEINYLGQLSHPNLVKLIGYCLE 142 G E L K TG + AVK + ++ +G + EI L ++ H N+V L Sbjct: 33 GAFSEVVLAEEK-ATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYES 91 Query: 143 DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRD 202 H LV + + G L + + +G Y + L + LDA + +LH + +++RD Sbjct: 92 PNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTL-IRQVLDA---VYYLHR--MGIVHRD 145 Query: 203 IKASNILL---DADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNAR 259 +K N+L D + +SDFGL++ GD V + GT GY APE ++ + Sbjct: 146 LKPENLLYYSQDEESKIMISDFGLSKMEGKGD---VMSTACGTPGYVAPEVLAQKPYSKA 202 Query: 260 SDVYSFGVLLLEILSG 275 D +S GV+ +L G Sbjct: 203 VDCWSIGVIAYILLCG 218 >6BDL-A nrPDB Length = 347 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 66/238 (27%), Positives = 102/238 (42%), Gaps = 22/238 (9%) Query: 57 FNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR 116 F LKL+ +F +G GGFG V L K A+K L + R Sbjct: 28 FANLKLS--DFNIIDTLGVGGFGRV--------ELVQLKSEESKTFAMKILKKRHIVDTR 77 Query: 117 --EWLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLP 173 E + + Q +H + + + +D L ++ E G L L RG++ Sbjct: 78 QQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTT 137 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 F V + A+LHS +IYRD+K N++LD AKL DFG A+ G + Sbjct: 138 RFYTACVV----EAFAYLHSK--GIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKT 191 Query: 234 YVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 + GT Y APE + + + +D +S G+L+ E+L+G P K N++ Sbjct: 192 WT---FCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNII 246 >2Y7J-A nrPDB Length = 365 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 65/234 (27%), Positives = 105/234 (44%), Gaps = 33/234 (14%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVK-------KLNQEGFQGHRE 117 + + P VIG G V + TG AVK +L+ E + RE Sbjct: 94 QKYDPKDVIGRGVSSVVRRC---------VHRATGHEFAVKIMEVTAERLSPEQLEEVRE 144 Query: 118 WLT-EINYLGQLS-HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 E + L Q++ HP+++ LI LV++ M+KG L ++L + A L Sbjct: 145 ATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVA----LSEK 200 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 ++ + ++FLH++ +++RD+K NILLD + +LSDFG + G+ Sbjct: 201 ETRSIMRSLLEAVSFLHAN--NIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGE---K 255 Query: 236 STRVMGTYGYAAPEY----MSSGH--LNARSDVYSFGVLLLEILSGKRALDHNR 283 + GT GY APE M H D+++ GV+L +L+G H R Sbjct: 256 LRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRR 309 >4L00-A nrPDB Length = 304 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 59/239 (24%), Positives = 110/239 (46%), Gaps = 37/239 (15%) Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 + Q+SH ++V L G C+ D ++V EF++ G L+ + R+ PW + VA Sbjct: 86 MRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLT-TPW--KFKVAKQL 142 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILL-----DADYNA--KLSDFGLARDGPMGDLSYVST 237 A L++L +++ ++ N+LL D++ KLSD G+ P+ LS Sbjct: 143 ASALSYLEDK--DLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGI----PITVLS--RQ 194 Query: 238 RVMGTYGYAAPEYMS-SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 + + APE + S +L+ +D +SFG L EI + P K++ L++ R Sbjct: 195 ECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEI-----CYNGEIPLKDKTLIEKERF 249 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 Y + R V +A + +C++++P RP ++R + +L++ Sbjct: 250 YESRCRPVT-------------PSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQ 295 >5WNO-A nrPDB Length = 330 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 95/207 (45%), Gaps = 14/207 (6%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLS 129 D +G G FG VF G P + + K+ Q E L E + +L Sbjct: 27 DKKLGAGAFGTVFAG-----IYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNMFRLR 81 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 H NL+K+IG+C+ D+ +V + G+L+N L + + L +V A G+ Sbjct: 82 HDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFL---KLHKENLGAREQVLYCYQIASGMQ 138 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR--DGPMGDLSYVSTRVMGTYGYAA 247 +L +V++RD+ N+L+ + +++DFGL++ ++ S +V + A Sbjct: 139 YLEKQ--RVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKV--AIKWLA 194 Query: 248 PEYMSSGHLNARSDVYSFGVLLLEILS 274 E S SDV++FGV EI++ Sbjct: 195 IEIFSKHCYTHASDVWAFGVTCWEIIT 221 >4QTB-A nrPDB Length = 380 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 88/331 (26%), Positives = 145/331 (43%), Gaps = 72/331 (21%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-REWLTEINYLGQLSHP 131 IGEG +G V + + T+ +A+KK++ Q + + L EI L + H Sbjct: 49 IGEGAYGMVSSAY---DHVRKTR------VAIKKISPFEHQTYCQRTLREIQILLRFRHE 99 Query: 132 NLVKLIG-------------YCLEDEHRLLVYEFMQKGSLEN-HLFRRGAYFKPLPWFLR 177 N++ + Y ++D +Y+ ++ L N H+ YF L LR Sbjct: 100 NVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHI----CYF--LYQILR 153 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG-PMGDLSYVS 236 GL ++HS V++RD+K SN+L++ + K+ DFGLAR P D + Sbjct: 154 ---------GLKYIHS--ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFL 202 Query: 237 TRVMGTYGYAAPEYMSSGHLNARS-DVYSFGVLLLEILS------GKRALDH-------- 281 T + T Y APE M + +S D++S G +L E+LS GK LD Sbjct: 203 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIL 262 Query: 282 NRPAKEE--NLVDW-ARPYLT---SKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFE 335 P++E+ +++ AR YL SK KV + P+ + + + L+F Sbjct: 263 GSPSQEDLNCIINMKARNYLQSLPSKTKVAW-------AKLFPKSDSKALDLLDRMLTFN 315 Query: 336 PKSRPTMDQVVRA--LQQLQDNLGKPSQTNP 364 P R T+++ + L+Q D +P P Sbjct: 316 PNKRITVEEALAHPYLEQYYDPTDEPVAEEP 346 >3H4J-B nrPDB Length = 336 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 62/212 (29%), Positives = 107/212 (50%), Gaps = 23/212 (10%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +GEG FG V +T T+ L ++L ++ H EI+YL L HP+ Sbjct: 17 LGEGSFGKV-----KLATHYKTQQKVALKFISRQLLKKS-DMHMRVEREISYLKLLRHPH 70 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLF--RRGAYFKPLPWFLRVNVALDAAKGLAF 190 ++KL ++V E+ G L +++ +R + +F ++ A++ + Sbjct: 71 IIKLYDVITTPTDIVMVIEY-AGGELFDYIVEKKRMTEDEGRRFFQQIICAIE------Y 123 Query: 191 LHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEY 250 H K+++RD+K N+LLD + N K++DFGL+ M D +++ T G+ YAAPE Sbjct: 124 CHRH--KIVHRDLKPENLLLDDNLNVKIADFGLS--NIMTDGNFLKTSC-GSPNYAAPEV 178 Query: 251 MSSGHLNA--RSDVYSFGVLLLEILSGKRALD 280 + +G L A DV+S G++L +L G+ D Sbjct: 179 I-NGKLYAGPEVDVWSCGIVLYVMLVGRLPFD 209 >4OTD-A nrPDB Length = 341 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 71/221 (32%), Positives = 103/221 (46%), Gaps = 24/221 (10%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE---W 118 L +F+ +V+G G FG V L+ +P +G + A+K L + E Sbjct: 9 LTLEDFKFLAVLGRGHFGKVL--------LSEFRP-SGELFAIKALKKGDIVARDEVESL 59 Query: 119 LTEINYLGQLS---HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 + E L ++ HP LV L G EH V E+ G L H+ + +P F Sbjct: 60 MCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHI-HSDVFSEPRAIF 118 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 V L GL FLH K++YRD+K N+LLD + K++DFGL ++G MG Sbjct: 119 YSACVVL----GLQFLHEH--KIVYRDLKLDNLLLDTEGYVKIADFGLCKEG-MGYGDRT 171 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 ST GT + APE ++ D + GVLL E+L G+ Sbjct: 172 ST-FCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGE 211 >5X3F-B nrPDB Length = 393 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 48/168 (28%), Positives = 83/168 (49%), Gaps = 11/168 (6%) Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 L E L ++ P LVKL ++ + +V E++ G + +HL R G + +P F Sbjct: 132 LNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAA 191 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR 238 + L +LHS + +IYRD+K N+L+D +++DFG A+ + + Sbjct: 192 QIVL----TFEYLHS--LDLIYRDLKPENLLIDQQGYIQVTDFGFAK-----RVKGRTWT 240 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK 286 + GT Y APE + S N D ++ GVL+ E+ +G ++P + Sbjct: 241 LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ 288 >3ORZ-A nrPDB Length = 316 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 50/215 (23%), Positives = 101/215 (46%), Gaps = 20/215 (9%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF--QGHREWLT-E 121 +F+ ++GEG F V + + T A+K L + + ++T E Sbjct: 37 EDFKFGKILGEGSFSTV---------VLARELATSREYAIKILEKRHIIKENKVPYVTRE 87 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLV-YEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 + + +L HP VKL +C +D+ +L + + G L ++ + G++ + F + Sbjct: 88 RDVMSRLDHPFFVKLY-FCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEI 146 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 L +LH +I+RD+K NILL+ D + +++DFG A+ + + Sbjct: 147 V----SALEYLHGK--GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFV 200 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 GT Y +PE ++ SD+++ G ++ ++++G Sbjct: 201 GTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAG 235 >4AU8-A nrPDB Length = 296 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 63/212 (29%), Positives = 98/212 (46%), Gaps = 24/212 (11%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL----NQEGFQGHREWLTEINYLGQL 128 IGEG +G VFK E T ++A+K++ + EG L EI L +L Sbjct: 14 IGEGTYGTVFKAKNRE---------THEIVALKRVRLDDDDEGVPSSA--LREICLLKEL 62 Query: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 H N+V+L D+ LV+EF + L+ + P + + KGL Sbjct: 63 KHKNIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGDLDPE---IVKSFLFQLLKGL 118 Query: 189 AFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAP 248 F HS V++RD+K N+L++ + KL+DFGLAR + Y + V T Y P Sbjct: 119 GFCHSR--NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV--TLWYRPP 174 Query: 249 EYMSSGHLNARS-DVYSFGVLLLEILSGKRAL 279 + + L + S D++S G + E+ + R L Sbjct: 175 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPL 206 >4WB7-A nrPDB Length = 405 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 47/157 (29%), Positives = 79/157 (50%), Gaps = 11/157 (7%) Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 L E L ++ P LVKL ++ + +V E++ G + +HL R G + +P F Sbjct: 144 LNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA 203 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR 238 + L +LHS + +IYRD+K N+L+D +++DFG A+ + + Sbjct: 204 QIVL----TFEYLHS--LDLIYRDLKPENLLIDQQGYIQVTDFGFAK-----RVKGRTWT 252 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 + GT Y APE + S N D ++ GVL+ E+ +G Sbjct: 253 LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAG 289 >5J0A-A nrPDB Length = 300 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 70/267 (26%), Positives = 127/267 (47%), Gaps = 28/267 (10%) Query: 103 AVKKLNQEGFQGHRE-----WLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKG 156 AVKK+N +R + E L L HPN+V + ++ L L E+ + Sbjct: 41 AVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEK 100 Query: 157 SLENHLFRR-GAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN 215 SL + + R A P P + + VAL+ A+GL +LH + K+++ DIK+SN+++ D+ Sbjct: 101 SLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEK-KLLHGDIKSSNVVIKGDFE 159 Query: 216 A-KLSDFG--LARDGPMGDLSYVSTRVMGTYGYAAPEYM-SSGHLNARSDVYSFGVLLLE 271 K+ D G L D M +++ +GT + E + +G + ++D+++FG+ L E Sbjct: 160 TIKICDVGVSLPLDENM-EVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWE 218 Query: 272 ILS--------GKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVR 323 +++ D ++ E + D A R + + LD Y ++ + Sbjct: 219 MMTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAALGTRPPINM--EELDESY--QKVIE 274 Query: 324 MASVAVQCLSFEPKSRPTMDQVVRALQ 350 + SV C + +PK RP+ +V AL+ Sbjct: 275 LFSV---CTNEDPKDRPSAAHIVEALE 298 >5AIR-A nrPDB Length = 430 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 62/214 (28%), Positives = 103/214 (48%), Gaps = 29/214 (13%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 VIG G FG V++ L +S G ++A+KK+ Q+ +RE + + +L H Sbjct: 71 VIGNGSFGVVYQAKLCDS---------GELVAIKKVLQDKRFKNRE----LQIMRKLDHC 117 Query: 132 NLVKLIGYCLED-EHRLLVYEFMQKGSLENHLFRRGAYF----KPLPWFLRVNVALDAAK 186 N+V+L + E + VY + + ++R ++ + LP + Sbjct: 118 NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 177 Query: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFGLARDGPMGD--LSYVSTRVMGTY 243 LA++HS + +RDIK N+LLD D KL DFG A+ G+ +SY+ +R Sbjct: 178 SLAYIHS--FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---- 231 Query: 244 GYAAPEYM-SSGHLNARSDVYSFGVLLLEILSGK 276 Y APE + + + DV+S G +L E+L G+ Sbjct: 232 -YRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ 264 >4AF3-A nrPDB Length = 292 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 61/236 (25%), Positives = 103/236 (43%), Gaps = 36/236 (15%) Query: 48 SSTP---VKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAV 104 S TP + FT ++ ++ RP +G+G FG V+ + + ++A+ Sbjct: 10 SGTPDILTRHFTIDDFEIG----RP---LGKGKFGNVYLA---------REKKSHFIVAL 53 Query: 105 K-----KLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLE 159 K ++ +EG + + EI L HPN+++L Y + L+ E+ +G L Sbjct: 54 KVLFKSQIEKEGVE--HQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELY 111 Query: 160 NHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLS 219 L + + + + + A L + H KVI+RDIK N+LL K++ Sbjct: 112 KELQKSCTFDEQR----TATIMEELADALMYCHGK--KVIHRDIKPENLLLGLKGELKIA 165 Query: 220 DFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 DFG + P S + GT Y PE + N + D++ GVL E+L G Sbjct: 166 DFGWSVHAP----SLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVG 217 >3C51-A nrPDB Length = 543 Score = 64.7 bits (156), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 57/210 (27%), Positives = 92/210 (43%), Gaps = 20/210 (9%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 V+G GGFG VF + T + + ++G+QG + E L ++ H Sbjct: 192 VLGRGGFGEVFAC---QMKATGKLYACKKLNKKRLKKRKGYQGA---MVEKKILAKV-HS 244 Query: 132 NLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFR----RGAYFKPLPWFLRVNVALDAAK 186 + + Y E + L LV M G + H++ + +P F + Sbjct: 245 RFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIV----S 300 Query: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYA 246 GL LH +IYRD+K N+LLD D N ++SD GLA + G + GT G+ Sbjct: 301 GLEHLHQR--NIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTK--TKGYAGTPGFM 356 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSGK 276 APE + + D ++ GV L E+++ + Sbjct: 357 APELLLGEEYDFSVDYFALGVTLYEMIAAR 386 >4I6B-A nrPDB Length = 308 Score = 64.3 bits (155), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 68/278 (24%), Positives = 129/278 (46%), Gaps = 36/278 (12%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL-TEINYLGQLSH 130 +G+GGF + + + LT K +I ++++ RE + EI L H Sbjct: 35 TLGKGGFAKCY----EMTDLTNNKVYAAKIIPHSRVSK---PHQREKIDKEIELHRILHH 87 Query: 131 PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKP-LPWFLRVNVALDAAKGLA 189 ++V+ Y + E+ ++ E+ + S+ + L R +P + ++LR V+ GL Sbjct: 88 KHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVS-----GLK 142 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPE 249 +LH ++++RD+K N ++ K+ DFGLA + L + + GT Y +PE Sbjct: 143 YLHEQ--EILHRDLKLGNFFINESMELKVGDFGLA--ARLEPLEHRRRTICGTPNYLSPE 198 Query: 250 YMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVD 309 ++ A SD+++ G ++ +L G+ P + NL + R S R+ + Sbjct: 199 VLNKQGHGAESDIWALGCVMYTMLLGR------PPFETTNLKETYR----SIREARYTMP 248 Query: 310 NRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 + L L +AS+ LS P+ RP++D ++R Sbjct: 249 SSL----LAPAKHLIASM----LSKNPEDRPSLDDIIR 278 >6CMJ-A nrPDB Length = 321 Score = 64.3 bits (155), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 52/162 (32%), Positives = 85/162 (52%), Gaps = 16/162 (9%) Query: 121 EINYLGQLSHPNLVKLIGYCLED---EHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 EI L +L HPN+VKL+ L+D +H +V+E + +G + KPL Sbjct: 92 EIAILKKLDHPNVVKLVE-VLDDPNEDHLYMVFELVNQGPV-----MEVPTLKPLSEDQA 145 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 D KG+ +LH K+I+RDIK SN+L+ D + K++DFG++ + D +T Sbjct: 146 RFYFQDLIKGIEYLHYQ--KIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNT 203 Query: 238 RVMGTYGYAAPEYMSSGH--LNARS-DVYSFGVLLLEILSGK 276 +GT + APE +S + ++ DV++ GV L + G+ Sbjct: 204 --VGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQ 243 >5YV8-A nrPDB Length = 298 Score = 64.3 bits (155), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 52/162 (32%), Positives = 85/162 (52%), Gaps = 16/162 (9%) Query: 121 EINYLGQLSHPNLVKLIGYCLED---EHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 EI L +L HPN+VKL+ L+D +H +V+E + +G + KPL Sbjct: 86 EIAILKKLDHPNVVKLVE-VLDDPNEDHLYMVFELVNQGPV-----MEVPTLKPLSEDQA 139 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 D KG+ +LH K+I+RDIK SN+L+ D + K++DFG++ + D +T Sbjct: 140 RFYFQDLIKGIEYLHYQ--KIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNT 197 Query: 238 RVMGTYGYAAPEYMSSGH--LNARS-DVYSFGVLLLEILSGK 276 +GT + APE +S + ++ DV++ GV L + G+ Sbjct: 198 --VGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQ 237 >2W4O-A nrPDB Length = 349 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 49/163 (30%), Positives = 78/163 (47%), Gaps = 20/163 (12%) Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 TEI L +LSHPN++KL LV E + G L + + +G Y + Sbjct: 97 TEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSE--------R 148 Query: 180 VALDAAK----GLAFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLARDGPMGDL 232 A DA K +A+LH + +++RD+K N+L D K++DFGL++ + + Sbjct: 149 DAADAVKQILEAVAYLHEN--GIVHRDLKPENLLYATPAPDAPLKIADFGLSK---IVEH 203 Query: 233 SYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 + V GT GY APE + D++S G++ +L G Sbjct: 204 QVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCG 246 >4X3F-A nrPDB Length = 337 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 96/222 (43%), Gaps = 30/222 (13%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL----TEI 122 +R +I GG G V++ + G +AVK L E F E++ E Sbjct: 14 YRLQRLIATGGMGQVWEAVDNR---------LGRRVAVKVLKSE-FSSDPEFIERFRAEA 63 Query: 123 NYLGQLSHPNLVKLIGYC---LEDEHRL--LVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 L+HP + + Y + E R LV E + L + L R G L Sbjct: 64 RTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTG--------RLS 115 Query: 178 VNVALDAAK--GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 + ALD + G A + +++RD+K NIL+ K++DFG+A+ ++ Sbjct: 116 LRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQT 175 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKR 277 VMGT Y APE + SDVYS GV+ E +SGKR Sbjct: 176 GM-VMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKR 216 >4CQG-A nrPDB Length = 331 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 70/285 (24%), Positives = 128/285 (44%), Gaps = 38/285 (13%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL-TEINYLGQLSHP 131 IG GGF TG ++A+K +++ + TEI+ L L H Sbjct: 17 IGTGGFA---------KVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQ 67 Query: 132 NLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAF 190 ++ +L + LE ++++ +V E+ G L +++ + + RV V +A+ Sbjct: 68 HICQLY-HVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEET---RV-VFRQILSAVAY 122 Query: 191 LHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEY 250 +HS +RD+K N+L D ++ KL DFGL P G+ Y G+ YAAPE Sbjct: 123 VHSQGYA--HRDLKPENLLFDENHKLKLIDFGLCA-KPKGNKDYHLQECCGSLAYAAPEL 179 Query: 251 MS-SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVD 309 + +L + +DV+S G+LL ++ G P ++N++ + + K +V Sbjct: 180 IQGKSYLGSEADVWSMGILLYVLMCG------FLPFDDDNVMALYKKIMRGKYEV----- 228 Query: 310 NRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQD 354 ++L ++ + Q L +PK R +M ++ +QD Sbjct: 229 ----PKWLSPSSILLLQ---QMLQVDPKKRISMRNLLNHPWVMQD 266 >4YNZ-A nrPDB Length = 342 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 64/221 (28%), Positives = 107/221 (48%), Gaps = 25/221 (11%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH--REWLTEINY 124 +R + +G+G G V G +T K +A+K +N+E + EI Sbjct: 12 YRLEKTLGKGQTGLVKLGI---HCVTCQK------VAIKIVNREKLSESVLMKVEREIAI 62 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF--KPLPWFLRVNVAL 182 L + HP+++KL ++ LV E + G L ++L ++G + +F ++ AL Sbjct: 63 LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL 122 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 D F HS + +RD+K N+LLD N +++DFG+A +GD S + T G+ Sbjct: 123 D------FCHSH--SICHRDLKPENLLLDERNNIRIADFGMA-SLQVGD-SLLETSC-GS 171 Query: 243 YGYAAPEYMSSGHLNAR-SDVYSFGVLLLEILSGKRALDHN 282 YA PE + + R +DV+S GV+L +L G D + Sbjct: 172 PHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDD 212 >4YHJ-A nrPDB Length = 584 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 72/225 (32%), Positives = 105/225 (46%), Gaps = 28/225 (12%) Query: 59 ELKLATRN-FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ---G 114 E + T+N FR V+G+GGFG V + TG + A KKL ++ + G Sbjct: 178 ERQPVTKNTFRHYRVLGKGGFGEVCACQVR---------ATGKMYACKKLQKKRIKKRKG 228 Query: 115 HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLP 173 L E L ++ +V L Y E + L LV M G L+ H++ G P Sbjct: 229 EAMALNEKRILEKVQSRFVVSL-AYAYETKDALCLVLTIMNGGDLKFHIYNLGN-----P 282 Query: 174 WFLRVNVALDAAK---GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMG 230 F AA+ GL L + +++YRD+K NILLD + ++SD GLA + P G Sbjct: 283 GFDEQRAVFYAAELCCGLEDLQRE--RIVYRDLKPENILLDDRGHIRISDLGLATEIPEG 340 Query: 231 DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 V RV GT GY APE +++ D + G L+ E++ G Sbjct: 341 --QRVRGRV-GTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQG 382 >4OW8-A nrPDB Length = 283 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 96/222 (43%), Gaps = 30/222 (13%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL----TEI 122 +R +I GG G V++ + G +AVK L E F E++ E Sbjct: 13 YRLQRLIATGGMGQVWEAVDNR---------LGRRVAVKVLKSE-FSSDPEFIERFRAEA 62 Query: 123 NYLGQLSHPNLVKLIGYC---LEDEHRL--LVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 L+HP + + Y + E R LV E + L + L R G L Sbjct: 63 RTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--------LS 114 Query: 178 VNVALDAAK--GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 + ALD + G A + +++RD+K NIL+ K++DFG+A+ ++ Sbjct: 115 LRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQT 174 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKR 277 VMGT Y APE + SDVYS GV+ E +SGKR Sbjct: 175 GM-VMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKR 215 >6E9W-A nrPDB Length = 443 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 83/342 (24%), Positives = 135/342 (39%), Gaps = 52/342 (15%) Query: 7 SRVKADIFHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRN 66 S V +D +G + +Y L + + + + LS +L++ + Sbjct: 51 SEVNSDCLLDGLDALVYDLDFPALRKNKNI-------DNFLSRYKDTINKIRDLRMKAED 103 Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE---WLTEIN 123 + VIG G FG E L K T V A+K L++ + + E + Sbjct: 104 YEVVKVIGRGAFG--------EVQLVRHK-STRKVYAMKLLSKFEMIKRSDSAFFWEERD 154 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPW----FLRVN 179 + + P +V+L +D + +V E+M G L N + Y P W V Sbjct: 155 IMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLM---SNYDVPEKWARFYTAEVV 211 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 +ALDA + F+H RD+K N+LLD + KL+DFG + T V Sbjct: 212 LALDAIHSMGFIH--------RDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAV 263 Query: 240 MGTYGYAAPEYMSS----GHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 GT Y +PE + S G+ D +S GV L E+L G + P ++LV Sbjct: 264 -GTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVG------DTPFYADSLVGTYS 316 Query: 296 PYLTSKRKVLLIVDNRLDTQ-------YLPEEAVRMASVAVQ 330 + K + DN + + +L + VR+ V+ Sbjct: 317 KIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVE 358 >1PHK-A nrPDB Length = 298 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 63/227 (27%), Positives = 103/227 (45%), Gaps = 20/227 (8%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINY 124 N+ P ++G G V + + + T V + E Q RE L E++ Sbjct: 18 NYEPKEILGRG-VSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 125 LGQLS-HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF-KPLPWFLRVNVAL 182 L ++S HPN+++L + LV++ M+KG L ++L + K +R + + Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEV 136 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 A LH + +++RD+K NILLD D N KL+DFG + G+ V GT Sbjct: 137 ICA-----LHK--LNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGE---KLREVCGT 186 Query: 243 YGYAAPEY----MSSGH--LNARSDVYSFGVLLLEILSGKRALDHNR 283 Y APE M+ H D++S GV++ +L+G H + Sbjct: 187 PSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRK 233 >4LRM-A nrPDB Length = 334 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/236 (25%), Positives = 113/236 (47%), Gaps = 27/236 (11%) Query: 62 LATRNFRPDSVIGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQE-GFQGHREWL 119 L F+ V+G G FG V+KG W+ P + +A+K+L + + ++E L Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWI------PEGEKVKIPVAIKELREATSPKANKEIL 69 Query: 120 TEINYLGQLSHP---NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR----GAYFKPL 172 E + + +P ++ +L+G CL +L+ + M G L +++ G+ + Sbjct: 70 DEAYVMASVDNPGNPHVCRLLGICLTSTVQLIT-QLMPFGCLLDYVREHKDNIGSQY--- 125 Query: 173 PWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDL 232 +N + AKG+ +L ++++RD+ A N+L+ + K++DFGLA+ + Sbjct: 126 ----LLNWCVQIAKGMNYLEDR--RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEK 179 Query: 233 SYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKE 287 Y + + A E + +SDV+S+GV + E+++ G + D PA E Sbjct: 180 EYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYD-GIPASE 234 >5JZN-A nrPDB Length = 280 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 60/219 (27%), Positives = 100/219 (45%), Gaps = 29/219 (13%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL-TEI 122 T ++ IG+G F V K ++ ST A+K + + +G + E+ Sbjct: 18 TERYKVGRTIGDGNFAVV-KECVERSTAREY--------ALKIIKKSKCRGKEHMIQNEV 68 Query: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 + L ++ HPN+V LI LV E ++ G L + + Y + + N+A Sbjct: 69 SILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLA- 127 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILL----DADYNAKLSDFGLAR--DGPMGDLSYVS 236 + +LHS + +++RDIK N+L+ D + KL DFGLA DGP+ Sbjct: 128 ---SAIKYLHS--LNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPL------- 175 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 V GT Y APE ++ + D+++ GV+ +L G Sbjct: 176 YTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCG 214 >4G3E-A nrPDB Length = 352 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/183 (30%), Positives = 89/183 (48%), Gaps = 17/183 (9%) Query: 98 TGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGS 157 TG AVKK+ E F+ + E+ LS P +V L G E + E ++ GS Sbjct: 98 TGFQCAVKKVRLEVFR-----VEELVACAGLSSPRIVPLYGAVREGPWVNIFMELLEGGS 152 Query: 158 LENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN-A 216 L + + G LP + A +GL +LH+ ++++ D+KA N+LL +D + A Sbjct: 153 LGQLIKQMGC----LPEDRALYYLGQALEGLEYLHTR--RILHGDVKADNVLLSSDGSRA 206 Query: 217 KLSDFG----LARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEI 272 L DFG L DG +G + GT + APE + +A+ D++S ++L + Sbjct: 207 ALCDFGHALCLQPDG-LGKSLLTGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMMLHM 265 Query: 273 LSG 275 L+G Sbjct: 266 LNG 268 >4M7I-A nrPDB Length = 299 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 61/233 (26%), Positives = 107/233 (45%), Gaps = 39/233 (16%) Query: 66 NFRPDSVIGEGGFGCVF--KGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEI 122 +F P +G GGFG VF K +D+ A+K++ + RE + E+ Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNY-----------AIKRIRLPNRELAREKVMREV 54 Query: 123 NYLGQLSHPNLVKLIGYCLEDEH---------RLLVYEFMQ---KGSLENHLFRRGAYFK 170 L +L HP +V+ LE ++ +Y MQ K +L++ + R + Sbjct: 55 KALAKLEHPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCT-IE 113 Query: 171 PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGL--ARDGP 228 + +++ L A+ + FLHS +++RD+K SNI D K+ DFGL A D Sbjct: 114 ERERSVCLHIFLQIAEAVEFLHSK--GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQD 171 Query: 229 MGDLSYVS--------TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEIL 273 + + ++ T +GT Y +PE + + + D++S G++L E+L Sbjct: 172 EEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL 224 >3NCG-A nrPDB Length = 486 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 99/213 (46%), Gaps = 32/213 (15%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH--REWLTEINYLGQLS 129 ++G+G FG V K + +T + AVK +N+ + L E+ L +L Sbjct: 29 MLGKGSFGEVLKC---KDRITQQE------YAVKVINKASAKNKDTSTILREVELLKKLD 79 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 HPN++KL + +V E G L + + +R K + G+ Sbjct: 80 HPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKR----KRFSEHDAARIIKQVFSGIT 135 Query: 190 FLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLA----RDGPMGDLSYVSTRVMGT 242 ++H +++RD+K NILL++ D + K+ DFGL+ ++ M D +GT Sbjct: 136 YMHKH--NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDR-------IGT 186 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 Y APE + G + + DV+S GV+L +LSG Sbjct: 187 AYYIAPEVL-RGTYDEKCDVWSAGVILYILLSG 218 >5J5T-A nrPDB Length = 370 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/205 (27%), Positives = 93/205 (45%), Gaps = 24/205 (11%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IG G +G V+K TG + A+K + E + EI + HPN Sbjct: 12 IGSGTYGDVYKA---------RNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPN 62 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 +V G L + + EF GSL++ G PL V+ + +GL +LH Sbjct: 63 IVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTG----PLSELQIAYVSRETLQGLYYLH 118 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR--VMGTYGYAAPEY 250 S ++RDIK +NILL + + KL+DFG++ + ++ R +GT + APE Sbjct: 119 SK--GKMHRDIKGANILLTDNGHVKLADFGVSAQ----ITATIAKRKAFIGTPYWMAPEV 172 Query: 251 MS---SGHLNARSDVYSFGVLLLEI 272 + G N D+++ G+ +E+ Sbjct: 173 AAVERKGGYNQLCDLWAVGITAIEL 197 >5N23-A nrPDB Length = 352 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 46/148 (31%), Positives = 75/148 (50%), Gaps = 10/148 (6%) Query: 128 LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 ++ P LVKL ++ + +V E+ G + +HL R G + +P F + L Sbjct: 99 VNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLT---- 154 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAA 247 +LHS + +IYRD+K N+L+D K++DFG A+ G + + GT Y A Sbjct: 155 FEYLHS--LDLIYRDLKPENLLIDQQGYIKVADFGFAKR-VKGRTPWT---LCGTPEYLA 208 Query: 248 PEYMSSGHLNARSDVYSFGVLLLEILSG 275 PE + S N D ++ GVL+ E+ +G Sbjct: 209 PEIILSKGYNKAVDWWALGVLIYEMAAG 236 >6B2Q-A nrPDB Length = 317 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 96/222 (43%), Gaps = 30/222 (13%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL----TEI 122 +R +I GG G V++ + G +AVK L E F E++ E Sbjct: 34 YRLQRLIATGGMGQVWEAVDNR---------LGRRVAVKVLKSE-FSSDPEFIERFRAEA 83 Query: 123 NYLGQLSHPNLVKLIGYC---LEDEHRL--LVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 L+HP + + Y + E R LV E + L + L R G L Sbjct: 84 RTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--------LS 135 Query: 178 VNVALDAAK--GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 + ALD + G A + +++RD+K NIL+ K++DFG+A+ ++ Sbjct: 136 LRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQT 195 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKR 277 VMGT Y APE + SDVYS GV+ E +SGKR Sbjct: 196 GM-VMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKR 236 >5D7A-A nrPDB Length = 308 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 62/230 (26%), Positives = 101/230 (43%), Gaps = 32/230 (13%) Query: 71 SVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSH 130 ++G G +G V+KG TG + A+K ++ G + E EIN L + SH Sbjct: 23 ELVGNGTYGQVYKG---------RHVKTGQLAAIKVMDVTGDE-EEEIKQEINMLKKYSH 72 Query: 131 P-NLVKLIGYCLE------DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 N+ G ++ D+ LV EF GS+ + + W + + Sbjct: 73 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWI--AYICRE 130 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR--DGPMGDLSYVSTRVMG 241 +GL+ LH KVI+RDIK N+LL + KL DFG++ D +G +G Sbjct: 131 ILRGLSHLHQH--KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR----RNTFIG 184 Query: 242 TYGYAAPEYMSSGH-----LNARSDVYSFGVLLLEILSGKRALDHNRPAK 286 T + APE ++ + +SD++S G+ +E+ G L P + Sbjct: 185 TPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 234 >2X4F-A nrPDB Length = 373 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 94/207 (45%), Gaps = 21/207 (10%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 ++G G FG V K + TGL +A K + G + E EI+ + QL H Sbjct: 96 ILGGGRFGQVHKC---------EETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHA 146 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 NL++L +LV E++ G L + + L L + +G+ + Sbjct: 147 NLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMK---QICEGIRHM 203 Query: 192 HSDPVKVIYRDIKASNILL---DADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAP 248 H + +++ D+K NIL DA K+ DFGLAR + V+ GT + AP Sbjct: 204 HQ--MYILHLDLKPENILCVNRDAK-QIKIIDFGLARRYKPREKLKVN---FGTPEFLAP 257 Query: 249 EYMSSGHLNARSDVYSFGVLLLEILSG 275 E ++ ++ +D++S GV+ +LSG Sbjct: 258 EVVNYDFVSFPTDMWSVGVIAYMLLSG 284 >3DFA-A nrPDB Length = 286 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 59/214 (27%), Positives = 99/214 (46%), Gaps = 32/214 (14%) Query: 71 SVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH--REWLTEINYLGQL 128 ++G+G FG V K + +T + AVK +N+ + L E+ L +L Sbjct: 28 CMLGKGSFGEVLKC---KDRITQQE------YAVKVINKASAKNKDTSTILREVELLKKL 78 Query: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 HPN++KL + +V E G L + + +R K + G+ Sbjct: 79 DHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKR----KRFSEHDAARIIKQVFSGI 134 Query: 189 AFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLA----RDGPMGDLSYVSTRVMG 241 ++H +++RD+K NILL++ D + K+ DFGL+ ++ M D +G Sbjct: 135 TYMHKH--NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDR-------IG 185 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 T Y APE + G + + DV+S GV+L +LSG Sbjct: 186 TAYYIAPEVL-RGTYDEKCDVWSAGVILYILLSG 218 >6CCF-A nrPDB Length = 290 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 63/199 (31%), Positives = 101/199 (50%), Gaps = 22/199 (11%) Query: 121 EINYLGQLSHPNLVKLIGYCLED---EHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 EI L +L H N+VKLI L+D ++ LV++ ++KG + + + +LR Sbjct: 78 EIAILKKLDHVNVVKLIE-VLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFSEEQARLYLR 136 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 D GL +LH K+++RDIK SN+LL D + K++DFG++ D ST Sbjct: 137 -----DVILGLEYLHCQ--KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSST 189 Query: 238 RVMGTYGYAAPEYMS-SGH-LNARS-DVYSFGVLLLEILSGKRA------LDHNRPAKEE 288 GT + APE +S SG + ++ DV++ GV L + GK L +R K E Sbjct: 190 --AGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNE 247 Query: 289 NLVDWARPYLTSKRKVLLI 307 +V P ++ + K L++ Sbjct: 248 PVVFPEEPEISEELKDLIL 266 >4FR4-A nrPDB Length = 384 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 61/213 (28%), Positives = 95/213 (44%), Gaps = 28/213 (13%) Query: 73 IGEGGFG--CVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH---REWLTEINYLGQ 127 IG+G FG C+ + K T + A+K +N++ R E+ + Sbjct: 23 IGKGSFGKVCIVQ-----------KNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQG 71 Query: 128 LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 L HP LV L ++E +V + + G L HL ++ +FK L + + Sbjct: 72 LEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHL-QQNVHFKEETVKLFI---CELVMA 127 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAA 247 L +L + ++I+RD+K NILLD + ++DF +A P T + GT Y A Sbjct: 128 LDYLQNQ--RIIHRDMKPDNILLDEHGHVHITDFNIAAMLPR---ETQITTMAGTKPYMA 182 Query: 248 PEYMSSGHLNARS---DVYSFGVLLLEILSGKR 277 PE SS S D +S GV E+L G+R Sbjct: 183 PEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRR 215 >4E7W-A nrPDB Length = 394 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 62/219 (28%), Positives = 105/219 (47%), Gaps = 40/219 (18%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 VIG G FG VF+ L ES +A+KK+ Q+ +R E+ + + HP Sbjct: 47 VIGNGSFGVVFQAKLVESD----------EVAIKKVLQDKRFKNR----ELQIMRIVKHP 92 Query: 132 NLVKLIGYCL-----EDEHRL-LVYEFMQKGSLENHLFRRGAYF----KPLPWFLRVNVA 181 N+V L + +DE L LV E++ + ++R ++ + +P L Sbjct: 93 NVVDLKAFFYSNGDKKDEVFLNLVLEYVPET-----VYRASRHYAKLKQTMPMLLIKLYM 147 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFGLARDGPMGD--LSYVSTR 238 + LA++HS + + +RDIK N+LLD KL DFG A+ G+ +SY+ +R Sbjct: 148 YQLLRSLAYIHS--IGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSR 205 Query: 239 VMGTYGYAAPEYM-SSGHLNARSDVYSFGVLLLEILSGK 276 Y APE + + + D++S G ++ E++ G+ Sbjct: 206 Y-----YRAPELIFGATNYTTNIDIWSTGCVMAELMQGQ 239 >3HZT-A nrPDB Length = 467 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 50/163 (30%), Positives = 81/163 (49%), Gaps = 19/163 (11%) Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 L E+ L QL HPN++KL + + + LV E + G L + + R F V Sbjct: 52 LDEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQK-------FSEV 104 Query: 179 NVAL---DAAKGLAFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLARDGPMGDL 232 + A+ G +LH +++RD+K N+LL++ D K+ DFGL+ +G Sbjct: 105 DAAVIMKQVLSGTTYLHKH--NIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVG-- 160 Query: 233 SYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 + R +GT Y APE + + + + DV+S GV+L +L G Sbjct: 161 GKMKER-LGTAYYIAPEVLRKKY-DEKCDVWSCGVILYILLCG 201 >3DXN-A nrPDB Length = 287 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 50/163 (30%), Positives = 81/163 (49%), Gaps = 19/163 (11%) Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 L E+ L QL HPN++KL + + + LV E + G L + + R F V Sbjct: 69 LDEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQK-------FSEV 121 Query: 179 NVAL---DAAKGLAFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLARDGPMGDL 232 + A+ G +LH +++RD+K N+LL++ D K+ DFGL+ +G Sbjct: 122 DAAVIMKQVLSGTTYLHKH--NIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVG-- 177 Query: 233 SYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 + R +GT Y APE + + + + DV+S GV+L +L G Sbjct: 178 GKMKER-LGTAYYIAPEVLRKKY-DEKCDVWSCGVILYILLCG 218 >5IG1-A nrPDB Length = 344 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 58/215 (26%), Positives = 92/215 (42%), Gaps = 33/215 (15%) Query: 71 SVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR--EWLTEINYLGQL 128 SVIG+G F V + TG V AVK + + + + EI L Sbjct: 23 SVIGKGAFSTVHRC---------VNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSL 73 Query: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 H ++V + ++ H LV+E++ G L + + R Y + DA+ + Sbjct: 74 QHEHIVSMRRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEK-----------DASACM 122 Query: 189 -----AFLHSDPVKVIYRDIKASNILL---DADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 A H +I+RD+K N+LL D + K++DFGLA G + Sbjct: 123 HQILSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYF---GFA 179 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 GT GY +PE + + DV++ GV+L +L G Sbjct: 180 GTPGYLSPEVIRRVPYDTAVDVWACGVILYILLVG 214 >4MYG-A nrPDB Length = 372 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 36/92 (39%), Positives = 52/92 (56%), Gaps = 8/92 (8%) Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGY 245 KGL ++HS V++RD+K N+ ++ D K+ DFGLAR YV TR Y Sbjct: 156 KGLKYIHS--AGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEMTGYVVTR-----WY 208 Query: 246 AAPE-YMSSGHLNARSDVYSFGVLLLEILSGK 276 APE +S H N D++S G ++ E+L+GK Sbjct: 209 RAPEVILSWMHYNQTVDIWSVGCIMAEMLTGK 240 >2JAM-A nrPDB Length = 304 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 63/221 (28%), Positives = 99/221 (44%), Gaps = 26/221 (11%) Query: 62 LATRNFRPD----SVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 + T N R V+G G F VF L + LT G + A+K + + Sbjct: 2 MQTTNIRKTFIFMEVLGSGAFSEVF---LVKQRLT------GKLFALKCIKKSPAFRDSS 52 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 EI L ++ H N+V L H LV + + G L + + RG Y + L Sbjct: 53 LENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEK-DASLV 111 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNIL-LDADYNAK--LSDFGLARDGPMGDLSY 234 + L A K +LH + +++RD+K N+L L + N+K ++DFGL++ G +S Sbjct: 112 IQQVLSAVK---YLHEN--GIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMS- 165 Query: 235 VSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 GT GY APE ++ + D +S GV+ +L G Sbjct: 166 ---TACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCG 203 >3HNG-A nrPDB Length = 360 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 43/112 (38%), Positives = 62/112 (55%), Gaps = 8/112 (7%) Query: 166 GAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR 225 G Y +P+ ++ + A+G+ FL S K I+RD+ A NILL + K+ DFGLAR Sbjct: 190 GFYKEPITMEDLISYSFQVARGMEFLSSR--KCIHRDLAARNILLSENNVVKICDFGLAR 247 Query: 226 DGPMGDLSYV---STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 D + YV TR+ + APE + + +SDV+S+GVLL EI S Sbjct: 248 D-IYKNPDYVRKGDTRL--PLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFS 296 >6DTL-A nrPDB Length = 364 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 67/244 (27%), Positives = 102/244 (41%), Gaps = 58/244 (23%) Query: 57 FNELKLATRNFRPDSV-IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH 115 F + T ++P + IG+G +G V E T +A+KK+ F Sbjct: 21 FGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSE---------TNESVAIKKI-ANAFDNK 70 Query: 116 ---REWLTEINYLGQLSHPNLVKL-------IGYCLEDEHRLLVYEFMQKGSLENHLFRR 165 + L EI L + H N+V + + D + + YE M Sbjct: 71 IDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVY--IAYELMDTD--------- 119 Query: 166 GAYFKPLPWFLRVNVALDAA----------KGLAFLHSDPVKVIYRDIKASNILLDADYN 215 L +R N AL +GL ++HS V++RD+K SN+LL+A+ + Sbjct: 120 ------LHQIIRSNQALSEEHCQYFLYQILRGLKYIHS--ANVLHRDLKPSNLLLNANCD 171 Query: 216 AKLSDFGLARDGPMGDL--SYVSTRVMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEI 272 K+ DFGLAR D YV TR Y APE ++S A DV+S G + +E+ Sbjct: 172 LKICDFGLARVTSESDFMTEYVVTR-----WYRAPELLLNSSDYTAAIDVWSVGCIFMEL 226 Query: 273 LSGK 276 + K Sbjct: 227 MDRK 230 >4Y83-A nrPDB Length = 332 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 65/215 (30%), Positives = 96/215 (44%), Gaps = 24/215 (11%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 KL RN D I G FG V+ L + T + +A K + + F+ + Sbjct: 70 KLTYRNIGSD-FIPRGAFGKVY---LAQDIKTKKR------MACKLIPVDQFKP-----S 114 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 ++ H N+ +L G L E L E + GS+ L G P+ F + V Sbjct: 115 DVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCG----PMREFEIIWV 170 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 KGL FLHS KVI+ DIK SNI+ + A L DFGL+ M + Y + Sbjct: 171 TKHVLKGLDFLHSK--KVIHHDIKPSNIVFMST-KAVLVDFGLSVQ--MTEDVYFPKDLR 225 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 GT Y +PE + + ++D+YS G L+ + +G Sbjct: 226 GTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTG 260 >5EFQ-A nrPDB Length = 347 Score = 61.2 bits (147), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 67/238 (28%), Positives = 105/238 (44%), Gaps = 39/238 (16%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL----NQEGFQGHREWLTEINYLGQ 127 +IGEG +G V+K TG ++A+KK+ +EGF + EI L Q Sbjct: 18 IIGEGTYGQVYKA---------RDKDTGEMVALKKVRLDNEKEGFPITA--IREIKILRQ 66 Query: 128 LSHPNLVKLIGYCLEDEHRL----------LVYEFMQK---GSLENHLFRRGAYFKPLPW 174 L+H +++ + + E L LV+E+M G LE+ L + Sbjct: 67 LTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNE--NHIKS 124 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSY 234 F+R +GL + H ++RDIK SNILL+ KL+DFGLAR + Sbjct: 125 FMR-----QLMEGLDYCHKK--NFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRP 177 Query: 235 VSTRVMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 + +V+ T Y PE + DV+S G +L E+ + K N+ + L+ Sbjct: 178 YTNKVI-TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELI 234 >3IS5-A nrPDB Length = 285 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 61/208 (29%), Positives = 96/208 (46%), Gaps = 21/208 (10%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL-TEINYLGQLSHP 131 +G G FG V ++E + +GL +K +N++ Q E + EI L L HP Sbjct: 30 LGSGAFGDVH--LVEERS-------SGLERVIKTINKDRSQVPMEQIEAEIEVLKSLDHP 80 Query: 132 NLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAF 190 N++K+ ED H + +V E + G L + A K L + LA+ Sbjct: 81 NIIKIFE-VFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAY 139 Query: 191 LHSDPVKVIYRDIKASNILL-DADYNA--KLSDFGLARDGPMGDLSYVSTRVMGTYGYAA 247 HS V+++D+K NIL D ++ K+ DFGLA + ST GT Y A Sbjct: 140 FHSQ--HVVHKDLKPENILFQDTSPHSPIKIIDFGLAE---LFKSDEHSTNAAGTALYMA 194 Query: 248 PEYMSSGHLNARSDVYSFGVLLLEILSG 275 PE + + D++S GV++ +L+G Sbjct: 195 PEVFKRD-VTFKCDIWSAGVVMYFLLTG 221 >5G6V-A nrPDB Length = 324 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 102/209 (48%), Gaps = 25/209 (11%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWLTEINYLGQLSHP 131 +GEG + V+KG +S LT ++A+K++ E +G + E++ L L H Sbjct: 10 LGEGTYATVYKG---KSKLTDN------LVALKEIRLEHEEGAPCTAIREVSLLKDLKHA 60 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL---DAAKGL 188 N+V L ++ LV+E++ K L+ +L G NV L +GL Sbjct: 61 NIVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNIIN------MHNVKLFLFQLLRGL 113 Query: 189 AFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAP 248 A+ H KV++RD+K N+L++ KL+DFGLAR + +Y + V T Y P Sbjct: 114 AYCHRQ--KVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVV--TLWYRPP 169 Query: 249 EY-MSSGHLNARSDVYSFGVLLLEILSGK 276 + + S + + D++ G + E+ +G+ Sbjct: 170 DILLGSTDYSTQIDMWGVGCIFYEMATGR 198 >3G2F-A nrPDB Length = 336 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 66/247 (26%), Positives = 108/247 (43%), Gaps = 54/247 (21%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 +E L N + +IG G +G V+KG LDE +P +AVK + F + Sbjct: 6 SEPSLDLDNLKLLELIGRGRYGAVYKGSLDE------RP-----VAVKVFS---FANRQN 51 Query: 118 WLTEINY--LGQLSHPNLVKLIGYCLEDE--------HRLLVYEFMQKGSLENHLFRRGA 167 ++ E N + + H N+ + I + DE LLV E+ GSL +L + Sbjct: 52 FINEKNIYRVPLMEHDNIARFI---VGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS 108 Query: 168 YFKPLPWFLRVNVALDAAKGLAFLHSDPVK-------VIYRDIKASNILLDADYNAKLSD 220 W +A +GLA+LH++ + + +RD+ + N+L+ D +SD Sbjct: 109 -----DWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISD 163 Query: 221 FGLA------RDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARS--------DVYSFG 266 FGL+ R G+ + +GT Y APE + G +N R D+Y+ G Sbjct: 164 FGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVL-EGAVNLRDCESALKQVDMYALG 222 Query: 267 VLLLEIL 273 ++ EI Sbjct: 223 LIYWEIF 229 >4QNY-A nrPDB Length = 354 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 86/317 (27%), Positives = 136/317 (42%), Gaps = 55/317 (17%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG---HREWLTEINYLG 126 + +IG G +G V + TK LV A+K++N+E F+ + L EI L Sbjct: 25 ERIIGAGSYGVVIRA-------RDTKSDNRLV-AMKRVNKEIFEEVILAKRILREIKLLA 76 Query: 127 QLSHPNLVKLIGYCL-ED----EHRLLVYEFMQKGSLENHLFRRGAYFKP--LPWFLRVN 179 + N++ L ED +H +V + M+ + R G + +F+ Sbjct: 77 HFNDDNIIGLRNILTPEDPENFDHFYIVMDIMETDL--KQVLRSGQELTEAHIQFFI--- 131 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 A + L +HS VI+RDI +NIL++ + + K+ DFGLA++ D T Sbjct: 132 --YQALRALHIIHS--AGVIHRDITPANILVNTNCDLKICDFGLAKEE--NDQGEYMTDY 185 Query: 240 MGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRAL--DHNRPAKEENLVD---- 292 + Y APE M +A+ DV+ G +L E+L G R L +R + + +VD Sbjct: 186 VTMRWYRAPELVMEDKDYSAQIDVWGIGCILGELL-GSRPLFQGKDRVNQLDKIVDVIGT 244 Query: 293 ------------WARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP 340 A+ YL K+ D R Q P + + L F PK R Sbjct: 245 PSEEDINSVGSSAAQKYL-KKKSHRPQADWR---QRYPTASPEALDLLRHMLVFNPKRRI 300 Query: 341 TMDQVVRA--LQQLQDN 355 T+ Q +R L+QL D+ Sbjct: 301 TVLQAMRHPFLEQLHDD 317 >1CM8-A nrPDB Length = 367 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 65/242 (26%), Positives = 107/242 (44%), Gaps = 39/242 (16%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH--- 115 E++ R+ +P +G G +G V + TG +A+KKL + FQ Sbjct: 22 EVRAVYRDLQP---VGSGAYGAV---------CSAVDGRTGAKVAIKKLYRP-FQSELFA 68 Query: 116 REWLTEINYLGQLSHPNLVKLIGYCLEDE------HRLLVYEFMQKGSLENHLFRRGAYF 169 + E+ L + H N++ L+ DE LV FM G+ L + Sbjct: 69 KRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM--GTDLGKLMKHEKLG 126 Query: 170 KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPM 229 + FL + KGL ++H+ +I+RD+K N+ ++ D K+ DFGLAR Sbjct: 127 EDRIQFLVYQML----KGLRYIHA--AGIIHRDLKPGNLAVNEDCELKILDFGLARQADS 180 Query: 230 GDLSYVSTRVMGTYGYAAPEYMSSGHLNARS-DVYSFGVLLLEILSGK---RALDHNRPA 285 YV TR Y APE + + ++ D++S G ++ E+++GK + DH Sbjct: 181 EMTGYVVTR-----WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQL 235 Query: 286 KE 287 KE Sbjct: 236 KE 237 >4RGJ-A nrPDB Length = 520 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 61/236 (25%), Positives = 109/236 (46%), Gaps = 46/236 (19%) Query: 54 SFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ 113 + FNE ++ ++G+G FG E L+ K TG A+K ++++ + Sbjct: 55 NVVFNE------QYKGIKILGKGSFG--------EVILSRDKH-TGHEYAIKVISKKHVK 99 Query: 114 ---GHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFK 170 L E+ L L H N++KL + ++ + LV + G L + + R +++ Sbjct: 100 RKTDKESLLREVELLKMLDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYE 159 Query: 171 PLPWFLRVNVALDAAK-------GLAFLHSDPVKVIYRDIKASNILLDA----DYNAKLS 219 +DAA+ G+ ++H + V++RD+K NILL+ D K+ Sbjct: 160 -----------IDAARIIKQILSGITYMHKN--NVVHRDLKPENILLETKNKEDMIIKII 206 Query: 220 DFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 DFGL+ + S +GT Y AP+ + G + + D++S GV+L +LSG Sbjct: 207 DFGLS---THFEYSKKMKDKIGTAYYIAPDVL-HGTYDEKCDIWSCGVILYILLSG 258 >3VHK-A nrPDB Length = 368 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 59/182 (32%), Positives = 74/182 (40%), Gaps = 31/182 (17%) Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 + + AKG+ FL S K I+RD+ A NILL K+ DFGLARD D YV Sbjct: 203 ICYSFQVAKGMEFLASR--KCIHRDLAARNILLSEKNVVKICDFGLARD-IYKDPDYVRK 259 Query: 238 -RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 + APE + +SDV+SFGVLL EI S A P Sbjct: 260 GDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLG-----------------ASP 302 Query: 297 YLTSK------RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQ 350 Y K R++ R PE M + C EP RPT ++V L Sbjct: 303 YPGVKIDEEFCRRLKEGTRMRAPDYTTPE----MYQTMLDCWHGEPSQRPTFSELVEHLG 358 Query: 351 QL 352 L Sbjct: 359 NL 360 >2F9G-A nrPDB Length = 353 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 102/225 (45%), Gaps = 36/225 (16%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG---HREWLTEI 122 +F+ S++GEG +G V + T TG ++A+KK+ E F L EI Sbjct: 12 DFQLKSLLGEGAYGVV---------CSATHKPTGEIVAIKKI--EPFDKPLFALRTLREI 60 Query: 123 NYLGQLSHPNLVKLIGY----CLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 L H N++ + E+ + + + + + + L + + + +F+ Sbjct: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFI-- 118 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR---------DGPM 229 + + LH VI+RD+K SN+L++++ + K+ DFGLAR P Sbjct: 119 ---YQTLRAVKVLHGS--NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPT 173 Query: 230 GDLSYVSTRVMGTYGYAAPEYMSSGHLNARS-DVYSFGVLLLEIL 273 G S + T + T Y APE M + +R+ DV+S G +L E+ Sbjct: 174 GQQSGM-TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF 217 >4D2V-A nrPDB Length = 356 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 54/191 (28%), Positives = 92/191 (48%), Gaps = 11/191 (5%) Query: 98 TGLVIAVKKLNQEGFQGHREWL-TEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQK 155 TG ++A+K +++ + TEI L L H ++ +L + LE +++ +V E+ Sbjct: 53 TGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLY-HVLETANKIFMVLEYCPG 111 Query: 156 GSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN 215 G L +++ + + RV V +A++HS +RD+K N+L D + Sbjct: 112 GELFDYIISQDRLSEEET---RV-VFRQIVSAVAYVHSQGYA--HRDLKPENLLFDEYHK 165 Query: 216 AKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMS-SGHLNARSDVYSFGVLLLEILS 274 KL DFGL P G+ Y G YAAPE + +L + +DV+S G+LL ++ Sbjct: 166 LKLIDFGLCAK-PKGNKDYHLQACCGALAYAAPELIQGKSYLGSEADVWSMGILLYVLMC 224 Query: 275 GKRALDHNRPA 285 G D + A Sbjct: 225 GFLPFDDDTAA 235 >4CZT-A nrPDB Length = 464 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 48/180 (26%), Positives = 91/180 (50%), Gaps = 14/180 (7%) Query: 102 IAVKKLNQEGFQGHR---EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSL 158 +A+K +++E ++ + EI+ + + HPN++++ V EF+ G L Sbjct: 39 VAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGEL 98 Query: 159 ENHLFRRGAYFK--PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA 216 + + G + +F ++ A+D + HS V +RD+K N+LLDA+ Sbjct: 99 FDKISSNGRLKEDEARKYFQQLINAVD------YCHSRGV--YHRDLKPENLLLDANGAL 150 Query: 217 KLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSS-GHLNARSDVYSFGVLLLEILSG 275 K+SDFGL+ + GT Y APE +++ G+ A++D++S GV+L +++G Sbjct: 151 KVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVILFVLMAG 210 >2BUJ-A nrPDB Length = 317 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 74/304 (24%), Positives = 125/304 (41%), Gaps = 58/304 (19%) Query: 73 IGEGGFGCV--FKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSH 130 +GEGGF V +G D G A+K++ Q E E + +H Sbjct: 37 LGEGGFSYVDLVEGLHD-----------GHFYALKRILCHEQQDREEAQREADMHRLFNH 85 Query: 131 PNLVKLIGYCLED----EHRLLVYEFMQKGSLENHLFR---RGAYFKP--LPWFLRVNVA 181 PN+++L+ YCL + L+ F ++G+L N + R +G + + W L Sbjct: 86 PNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLL----- 140 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFG------LARDGPMGDLS-- 233 L +GL +H+ +RD+K +NILL + L D G + +G L+ Sbjct: 141 LGICRGLEAIHAK--GYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQ 198 Query: 234 -YVSTRVMGTYGYAAPEYMS-SGH--LNARSDVYSFGVLLLEILSGKRALDHNRPAKEEN 289 + + R T Y APE S H ++ R+DV+S G +L ++ G+ D Sbjct: 199 DWAAQRC--TISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDM-------- 248 Query: 290 LVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRAL 349 V L V N+L P + + + ++ +P RP + ++ L Sbjct: 249 -------VFQKGDSVALAVQNQLSIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQL 301 Query: 350 QQLQ 353 + LQ Sbjct: 302 EALQ 305 >1KOB-A nrPDB Length = 387 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 92/206 (44%), Gaps = 21/206 (10%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +G G FG V + + TG V K +N EI+ + QL HP Sbjct: 59 LGSGAFGVVHRC---------VEKATGRVFVAKFINTPYPLDKYTVKNEISIMNQLHHPK 109 Query: 133 LVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 L+ L ED++ + L+ EF+ G L + R A + +N A +GL + Sbjct: 110 LINLHD-AFEDKYEMVLILEFLSGGELFD---RIAAEDYKMSEAEVINYMRQACEGLKHM 165 Query: 192 HSDPVKVIYRDIKASNILLDAD--YNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPE 249 H +++ DIK NI+ + + K+ DFGLA ++ V+T T +AAPE Sbjct: 166 HEH--SIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTT---ATAEFAAPE 220 Query: 250 YMSSGHLNARSDVYSFGVLLLEILSG 275 + + +D+++ GVL +LSG Sbjct: 221 IVDREPVGFYTDMWAIGVLGYVLLSG 246 >3LIJ-A nrPDB Length = 494 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 48/163 (29%), Positives = 81/163 (49%), Gaps = 19/163 (11%) Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 L E+ L L HPN++KL + + + LV E + G L + + R F V Sbjct: 84 LEEVAVLKLLDHPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMK-------FNEV 136 Query: 179 NVAL---DAAKGLAFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLARDGPMGDL 232 + A+ G+ +LH +++RD+K N+LL++ D K+ DFGL+ + Sbjct: 137 DAAVIIKQVLSGVTYLHKH--NIVHRDLKPENLLLESKEKDALIKIVDFGLS--AVFENQ 192 Query: 233 SYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 + R +GT Y APE + + + + DV+S GV+L +L+G Sbjct: 193 KKMKER-LGTAYYIAPEVLRKKY-DEKCDVWSIGVILFILLAG 233 >4YZB-A nrPDB Length = 491 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 46/153 (30%), Positives = 75/153 (49%), Gaps = 21/153 (13%) Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 HPN++KL + + + LV E G L + + R K + G+ Sbjct: 89 HPNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISR----KRFSEVDAARIIRQVLSGIT 144 Query: 190 FLHSDPVKVIYRDIKASNILLD---ADYNAKLSDFGLARDGPMGDLSYVSTRVM----GT 242 ++H + K+++RD+K N+LL+ D N ++ DFGL+ + ST+ M GT Sbjct: 145 YMHKN--KIVHRDLKPENLLLENKRKDANIRIIDFGLS-------THFESTKKMKDKIGT 195 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 Y APE + G + + DV+S GV+L +LSG Sbjct: 196 AYYIAPEVL-HGTYDEKCDVWSTGVILYILLSG 227 >2YCR-A nrPDB Length = 323 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 51/172 (29%), Positives = 87/172 (50%), Gaps = 20/172 (11%) Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLF--RRGAYFKPLPWFLR 177 TEI L +L+HP ++K+ + + E +V E M+ G L + + +R +F + Sbjct: 64 TEIEILKKLNHPCIIKIKNF-FDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQ 122 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILL---DADYNAKLSDFGLARDGPMGDLSY 234 + +A+ +LH + +I+RD+K N+LL + D K++DFG ++ +G+ S Sbjct: 123 MLLAVQ------YLHEN--GIIHRDLKPENVLLSSQEEDCLIKITDFGHSK--ILGETSL 172 Query: 235 VSTRVMGTYGYAAPEYMSS---GHLNARSDVYSFGVLLLEILSGKRALDHNR 283 + T + GT Y APE + S N D +S GV+L LSG +R Sbjct: 173 MRT-LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHR 223 >6CQF-A nrPDB Length = 297 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 94/204 (46%), Gaps = 22/204 (10%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +G G +G VFK +G ++A+K + E EI L H N Sbjct: 24 LGGGTYGEVFKA---------RDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHAN 74 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN-VALDAAKGLAFL 191 +V G L + + EF GSL++ G+ + L+++ V + +GLA+L Sbjct: 75 IVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSE-----LQISYVCREVLQGLAYL 129 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM 251 HS K I+RDIK +NIL++ +L+DFG++ +G +GT + APE Sbjct: 130 HSQ--KKIHRDIKGANILINDAGEVRLADFGIS--AQIGATLARRLAFIGTPYWMAPEVA 185 Query: 252 S---SGHLNARSDVYSFGVLLLEI 272 + G N D++S G+ +E+ Sbjct: 186 AVALKGGYNELCDIWSLGITAIEL 209 >5Z33-A nrPDB Length = 425 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 37/94 (39%), Positives = 55/94 (58%), Gaps = 7/94 (7%) Query: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD---GPMGDLSYVSTRVMGTY 243 GL ++HS V++RD+K N+L++AD K+ DFGLAR P + Y+ T + T Sbjct: 146 GLKYIHS--ANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYM-TEYVATR 202 Query: 244 GYAAPEYMSSGHLNARS-DVYSFGVLLLEILSGK 276 Y APE M S ++ DV+S G +L E+L G+ Sbjct: 203 WYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGR 236 >1V0B-A nrPDB Length = 288 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 95/208 (45%), Gaps = 25/208 (12%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL----NQEGFQGHREWLTEINYLGQL 128 IGEG +G V+K + G A+KK+ EG + EI+ L +L Sbjct: 10 IGEGTYGVVYKA----------QNNYGETFALKKIRLEKEDEGIPSTT--IREISILKEL 57 Query: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 H N+VKL + +LV+E + + + G L + L G+ Sbjct: 58 KHSNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGG----LESVTAKSFLLQLLNGI 113 Query: 189 AFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAP 248 A+ H +V++RD+K N+L++ + K++DFGLAR + Y T + T Y AP Sbjct: 114 AYCHDR--RVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKY--THEVVTLWYRAP 169 Query: 249 EY-MSSGHLNARSDVYSFGVLLLEILSG 275 + M S + D++S G + E+++G Sbjct: 170 DVLMGSKKYSTTIDIWSVGCIFAEMVNG 197 >1ZXE-A nrPDB Length = 303 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 62/241 (25%), Positives = 106/241 (43%), Gaps = 55/241 (22%) Query: 66 NFRPDSVIGEGGFGCVFKG---------WLDESTLTPTKPGTGL--VIAVKKLN-QEGFQ 113 +F +V+G+G FG V K + + T K T L V+ + LN Q + Sbjct: 7 DFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQYVVR 66 Query: 114 GHREWLTEINYLGQLS----HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF 169 + WL N++ ++ L + YC E+R L Y+ + +L +R Y+ Sbjct: 67 YYAAWLERRNFVKPMTAVKKKSTLFIQMEYC---ENRTL-YDLIHSENLNQ---QRDEYW 119 Query: 170 KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD--- 226 + L + L+++HS + I+R++K NI +D N K+ DFGLA++ Sbjct: 120 RLFRQIL---------EALSYIHSQGI--IHRNLKPMNIFIDESRNVKIGDFGLAKNVHR 168 Query: 227 -------------GPMGDLSYVSTRVMGTYGYAAPEYMS-SGHLNARSDVYSFGVLLLEI 272 G +L T +GT Y A E + +GH N + D+YS G++ E+ Sbjct: 169 SLDILKLDSQNLPGSSDNL----TSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEM 224 Query: 273 L 273 + Sbjct: 225 I 225 >5FET-A nrPDB Length = 847 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 59/224 (26%), Positives = 94/224 (41%), Gaps = 35/224 (15%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVK--------KLNQEG- 111 K+ + +IG G FG V L KP T + A+K LNQ+ Sbjct: 529 KVEMHELETERIIGRGTFGTV--------KLVHHKP-TQIRYALKCVSKRSIISLNQQNN 579 Query: 112 FQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKP 171 + RE E + HP +++L+ + + E + G L + + + G KP Sbjct: 580 IKLEREITAEND------HPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKLGLLSKP 633 Query: 172 LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGD 231 F ++ L + +LH ++YRD+K NILLD KL DFG A+ Sbjct: 634 QAQFYLGSIIL----AIEYLHER--NIVYRDLKPENILLDKQGYVKLIDFGCAK-----K 682 Query: 232 LSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 + + ++GT Y APE + D+++ GV L E + G Sbjct: 683 IQGRAYTLVGTPHYMAPEVILGKGYGCTVDIWALGVCLYEFICG 726 >3KN6-A nrPDB Length = 325 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 46/151 (30%), Positives = 73/151 (48%), Gaps = 13/151 (8%) Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFK-PLPWFLRVNVALDAAKGL 188 HPN+VKL + H LV E + G L + ++ + + + +R V+ Sbjct: 65 HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVS------- 117 Query: 189 AFLHSDPVKVIYRDIKASNILL---DADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGY 245 A H V V++RD+K N+L + + K+ DFG AR P D + T T Y Sbjct: 118 AVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKP-PDNQPLKTPCF-TLHY 175 Query: 246 AAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 AAPE ++ + D++S GV+L +LSG+ Sbjct: 176 AAPELLNQNGYDESCDLWSLGVILYTMLSGQ 206 >5U6Y-A nrPDB Length = 461 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 50/183 (27%), Positives = 83/183 (45%), Gaps = 24/183 (13%) Query: 101 VIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLEN 160 +I KKL+ + H++ E L HPN+V+L E+ H L+++ + G L Sbjct: 32 IINTKKLSA---RDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFE 88 Query: 161 HLFRRGAYFKPLPWFLRVNVALDAAKGL-----AFLHSDPVKVIYRDIKASNILLDADYN 215 + R Y + DA+ + A LH + V++RD+K N+LL + Sbjct: 89 DIVAREYYSEA-----------DASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLK 137 Query: 216 A---KLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEI 272 KL+DFGLA + ++ GT GY +PE + D+++ GV+L + Sbjct: 138 GAAVKLADFGLAIEVEGEQQAWFG--FAGTPGYLSPEVLRKDPYGKPVDLWACGVILYIL 195 Query: 273 LSG 275 L G Sbjct: 196 LVG 198 >5O0Y-A nrPDB Length = 579 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 62/234 (26%), Positives = 103/234 (44%), Gaps = 37/234 (15%) Query: 115 HREWLTEINYLGQLSHPNLVKLIGY-CLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLP 173 H+ E +L HP +VKL Y L+ + V E+ + L+ +L K + Sbjct: 332 HKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYL----KQHKLMS 387 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILL---DADYNAKLSDFGLARDGPMG 230 ++ + L +L+ +I+ D+K NILL A K++DFGL++ M Sbjct: 388 EKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSK--IMD 445 Query: 231 DLSYVSTRVM-------GTYGYAAPEYMSSGH----LNARSDVYSFGVLLLEILSGKRAL 279 D SY S M GTY Y PE G ++ + DV+S GV+ + L G++ Sbjct: 446 DDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF 505 Query: 280 DHNRPAK---EENLVDWA-------RPYLTSKRKVLL------IVDNRLDTQYL 317 HN+ + +EN + A +P +T + K + ++R+D Q L Sbjct: 506 GHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQL 559 >4RT7-A nrPDB Length = 415 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 39/98 (39%), Positives = 53/98 (54%), Gaps = 10/98 (10%) Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 A AKG+ FL ++RD+ A N+L+ K+ DFGLARD M D +YV V Sbjct: 249 AYQVAKGMEFLEFK--SCVHRDLAARNVLVTHGKVVKICDFGLARD-IMSDSNYV---VR 302 Query: 241 GT----YGYAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 G + APE + G +SDV+S+G+LL EI S Sbjct: 303 GNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFS 340 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 32/100 (32%), Positives = 50/100 (50%), Gaps = 6/100 (6%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL-TEIN 123 N V+G G FG V ++ + +K G + +AVK L ++ RE L +E+ Sbjct: 65 ENLEFGKVLGSGAFGKV----MNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELK 120 Query: 124 YLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHL 162 + QL SH N+V L+G C L++E+ G L N+L Sbjct: 121 MMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYL 160 >3SOA-A nrPDB Length = 444 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 49/186 (26%), Positives = 84/186 (45%), Gaps = 24/186 (12%) Query: 98 TGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGS 157 ++I KKL+ + H++ E L HPN+V+L E+ H L+++ + G Sbjct: 40 AAMIINTKKLSA---RDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGE 96 Query: 158 LENHLFRRGAYFKPLPWFLRVNVALDAAKGL-----AFLHSDPVKVIYRDIKASNILLDA 212 L + R Y + DA+ + A LH + V++R++K N+LL + Sbjct: 97 LFEDIVAREYYSEA-----------DASHCIQQILEAVLHCHQMGVVHRNLKPENLLLAS 145 Query: 213 DYN---AKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLL 269 KL+DFGLA + ++ GT GY +PE + D+++ GV+L Sbjct: 146 KLKGAAVKLADFGLAIEVEGEQQAWFG--FAGTPGYLSPEVLRKDPYGKPVDLWACGVIL 203 Query: 270 LEILSG 275 +L G Sbjct: 204 YILLVG 209 >3I6U-A nrPDB Length = 419 Score = 58.5 bits (140), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 51/172 (29%), Positives = 87/172 (50%), Gaps = 20/172 (11%) Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLF--RRGAYFKPLPWFLR 177 TEI L +L+HP ++K+ + + E +V E M+ G L + + +R +F + Sbjct: 189 TEIEILKKLNHPCIIKIKNF-FDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQ 247 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILL---DADYNAKLSDFGLARDGPMGDLSY 234 + +A+ +LH + +I+RD+K N+LL + D K++DFG ++ +G+ S Sbjct: 248 MLLAVQ------YLHEN--GIIHRDLKPENVLLSSQEEDCLIKITDFGHSK--ILGETSL 297 Query: 235 VSTRVMGTYGYAAPEYMSS---GHLNARSDVYSFGVLLLEILSGKRALDHNR 283 + T + GT Y APE + S N D +S GV+L LSG +R Sbjct: 298 MRT-LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHR 348 >2VZ6-A nrPDB Length = 313 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 50/183 (27%), Positives = 83/183 (45%), Gaps = 24/183 (13%) Query: 101 VIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLEN 160 +I KKL+ + H++ E L HPN+V+L E+ H L+++ + G L Sbjct: 54 IINTKKLSA---RDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFE 110 Query: 161 HLFRRGAYFKPLPWFLRVNVALDAAKGL-----AFLHSDPVKVIYRDIKASNILLDADYN 215 + R Y + DA+ + A LH + V++RD+K N+LL + Sbjct: 111 DIVAREYYSEA-----------DASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLK 159 Query: 216 ---AKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEI 272 KL+DFGLA + ++ GT GY +PE + D+++ GV+L + Sbjct: 160 GAAVKLADFGLAIEVEGEQQAWFG--FAGTPGYLSPEVLRKDPYGKPVDLWACGVILYIL 217 Query: 273 LSG 275 L G Sbjct: 218 LVG 220 >3VN9-A nrPDB Length = 340 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 74/308 (24%), Positives = 129/308 (41%), Gaps = 37/308 (12%) Query: 47 LSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKK 106 L S S ++ + P +G G +G V ++ P+ G ++AVK+ Sbjct: 33 LDSKACISIGNQNFEVKADDLEPIMELGRGAYGVV-----EKMRHVPS----GQIMAVKR 83 Query: 107 LNQE-GFQGHREWLTEINY-LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFR 164 + Q + L +++ + + P V G + + E M SL+ + Sbjct: 84 IRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQ 142 Query: 165 RGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLA 224 + +P + +A+ K L LHS + VI+RD+K SN+L++A K+ DFG++ Sbjct: 143 VIDKGQTIPEDILGKIAVSIVKALEHLHSK-LSVIHRDVKPSNVLINALGQVKMCDFGIS 201 Query: 225 RDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLN-----ARSDVYSFGVLLLEILSGKRAL 279 G + D S T G Y APE ++ LN +SD++S G+ ++E+ + Sbjct: 202 --GYLVD-SVAKTIDAGCKPYMAPERINP-ELNQKGYSVKSDIWSLGITMIELAILRFPY 257 Query: 280 DHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSR 339 D W P+ K+ V+ +L E V S QCL K R Sbjct: 258 D-----------SWGTPFQQLKQ-VVEEPSPQLPADKFSAEFVDFTS---QCLKKNSKER 302 Query: 340 PTMDQVVR 347 PT ++++ Sbjct: 303 PTYPELMQ 310 >6ED6-A nrPDB Length = 415 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 63/227 (27%), Positives = 96/227 (42%), Gaps = 32/227 (14%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-- 117 L++ ++ VIG G FG E L K + V A+K L++ + Sbjct: 83 LQMKAEDYDVVKVIGRGAFG--------EVQLVRHK-ASQKVYAMKLLSKFEMIKRSDSA 133 Query: 118 -WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF- 175 + E + + + P +V+L +D + +V E+M G L N + Y P W Sbjct: 134 FFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLM---SNYDVPEKWAK 190 Query: 176 ---LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDL 232 V +ALDA + +H RD+K N+LLD + KL+DFG + Sbjct: 191 FYTAEVVLALDAIHSMGLIH--------RDVKPDNMLLDKHGHLKLADFGTCMKMDETGM 242 Query: 233 SYVSTRVMGTYGYAAPEYMSS----GHLNARSDVYSFGVLLLEILSG 275 + T V GT Y +PE + S G D +S GV L E+L G Sbjct: 243 VHCDTAV-GTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVG 288 >4B6L-A nrPDB Length = 281 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 67/286 (23%), Positives = 125/286 (43%), Gaps = 38/286 (13%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEIN 123 R + ++G+GGF ++ T T+ G+ + V ++ RE L EI Sbjct: 9 RTYLKGRLLGKGGFARCYEA-------TDTETGSAYAVKVIPQSRVAKPHQREKILNEIE 61 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVY-EFMQKGSLENHLFRRGAYFKP-LPWFLRVNVA 181 L H ++V+ + ED + ++ E + SL + R +P + ++LR ++ Sbjct: 62 LHRDLQHRHIVRF-SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILS 120 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 GL +LH +++RD+K N + + K+ DFGLA + + G Sbjct: 121 -----GLKYLHQR--GILHRDLKLGNFFITENMELKVGDFGLA--ARLEPPEQRKKTICG 171 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK 301 T Y APE + +DV+S G ++ +L G + P + +L + R Sbjct: 172 TPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCG------SPPFETADLKETYR----CI 221 Query: 302 RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 ++V + L LP + +A++ L P+ RP++DQ++R Sbjct: 222 KQVHYTLPASLS---LPARQL-LAAI----LRASPRDRPSIDQILR 259 >4CRS-A nrPDB Length = 341 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 68/230 (29%), Positives = 100/230 (43%), Gaps = 29/230 (12%) Query: 53 KSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF 112 + F FN ++FR +V+ G FG V L T + A+K L + Sbjct: 5 QRFQFN-----LQDFRCCAVLLRGHFGKV---------LLAEYKNTNEMFAIKALKKGDI 50 Query: 113 QGHRE---WLTE---INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRG 166 E + E + + HP LV L EH V E+ G L H+ Sbjct: 51 VARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHI-HTD 109 Query: 167 AYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD 226 + +P F V L GL +LH K++YRD+K N+LLD + K++DFGL ++ Sbjct: 110 VFSEPRAVFYAACVVL----GLQYLHEH--KIVYRDLKLDNLLLDTEGFVKIADFGLCKE 163 Query: 227 GPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 G MG ST GT + APE ++ D + GVL+ E+L G+ Sbjct: 164 G-MGYGDRTST-FCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGE 211 >4U41-A nrPDB Length = 332 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 68/256 (26%), Positives = 109/256 (42%), Gaps = 35/256 (13%) Query: 48 SSTPVKSFT---FNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAV 104 + +P KS + L+ F V+G G +G V+KG TG + A+ Sbjct: 4 NDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKG---------RHVKTGQLAAI 54 Query: 105 KKLNQEGFQGHREWLTEINYLGQLSHP-NLVKLIGYCLE------DEHRLLVYEFMQKGS 157 K ++ + L EIN L + SH N+ G ++ D+ LV EF GS Sbjct: 55 KVMDVTEDEEEEIKL-EINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGS 113 Query: 158 LENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAK 217 + + + W ++ + +GLA LH VI+RDIK N+LL + K Sbjct: 114 ITDLVKNTKGNTLKEDWI--AYISREILRGLAHLHIH--HVIHRDIKGQNVLLTENAEVK 169 Query: 218 LSDFGLAR--DGPMGDLSYVSTRVMGTYGYAAPEYMSSGH-----LNARSDVYSFGVLLL 270 L DFG++ D +G +GT + APE ++ + RSD++S G+ + Sbjct: 170 LVDFGVSAQLDRTVGR----RNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAI 225 Query: 271 EILSGKRALDHNRPAK 286 E+ G L P + Sbjct: 226 EMAEGAPPLCDMHPMR 241 >5DYK-A nrPDB Length = 853 Score = 57.8 bits (138), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 62/246 (25%), Positives = 105/246 (42%), Gaps = 31/246 (12%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKK----LNQEG-FQGH 115 K+ + +IG G FG V PTK L K+ LNQ+ + Sbjct: 535 KVEMDELETERIIGRGTFGTV-----KLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLE 589 Query: 116 REWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 RE E + HP +++L+ + ++ + E + G L + + + G K F Sbjct: 590 REITAEND------HPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQF 643 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 ++ L + +LH ++YRD+K NILLD KL DFG A+ + +Y Sbjct: 644 YLGSIIL----AIEYLHER--NIVYRDLKPENILLDKQGYVKLIDFGCAK--KVQGRAYT 695 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 ++GT Y APE + D+++ G+ L E + G ++ EE+ ++ R Sbjct: 696 ---LVGTPHYMAPEVILGKGYGCTVDIWALGICLYEFICGPLPFGND----EEDQLEIFR 748 Query: 296 PYLTSK 301 LT + Sbjct: 749 DILTGQ 754 >4BGQ-A nrPDB Length = 304 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 56/207 (27%), Positives = 93/207 (44%), Gaps = 18/207 (8%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL--NQEGFQGHREWLTEINYLGQLS 129 V+GEG +G V K E T ++A+KK ++E + L E+ L L Sbjct: 19 VVGEGAYGVVLKCRHKE---------THEIVAIKKFKDSEENEEVKETTLRELKMLRTLK 69 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 N+V+L LV+E+++K LE L P P ++ + K + Sbjct: 70 QENIVELKEAFRRRGKLYLVFEYVEKNMLE--LLEEMPNGVP-PEKVKSYIY-QLIKAIH 125 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPE 249 + H + +++RDIK N+L+ + KL DFG AR+ G+ + V T Y +PE Sbjct: 126 WCHKN--DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEV-ATRWYRSPE 182 Query: 250 YMSSGHLNARSDVYSFGVLLLEILSGK 276 + D++S G +L E+ G+ Sbjct: 183 LLLGAPYGKSVDMWSVGCILGELSDGQ 209 >2BDW-A nrPDB Length = 362 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 59/229 (25%), Positives = 98/229 (42%), Gaps = 29/229 (12%) Query: 55 FTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGL-----VIAVKKLNQ 109 F N + N+ +G+G F V + TGL +I KKL+ Sbjct: 19 FMMNASTKFSDNYDVKEELGKGAFSVVRRC---------VHKTTGLEFAAKIINTKKLSA 69 Query: 110 EGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF 169 FQ E +L HPN+V+L E+ LV++ + G L + R Y Sbjct: 70 RDFQKLER---EARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYS 126 Query: 170 KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA---KLSDFGLARD 226 + + + +A+ HS+ +++R++K N+LL + KL+DFGLA + Sbjct: 127 EADA----SHCIQQILESIAYCHSN--GIVHRNLKPENLLLASKAKGAAVKLADFGLAIE 180 Query: 227 GPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 + D S GT GY +PE + + D+++ GV+L +L G Sbjct: 181 --VND-SEAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVG 226 >6CKI-A nrPDB Length = 316 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 48/141 (34%), Positives = 72/141 (51%), Gaps = 19/141 (13%) Query: 148 LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASN 207 LV+E M+ GS+ +H+ +R +F L + V D A L FLH+ + +RD+K N Sbjct: 88 LVFEKMRGGSILSHIHKR-RHFNELEASV---VVQDVASALDFLHNK--GIAHRDLKPEN 141 Query: 208 ILLDADYN---AKLSDFGLARDGPM-GDLSYVSTRVM----GTYGYAAPEYMSSGHLNA- 258 IL + K+ DFGL + GD S +ST + G+ Y APE + + A Sbjct: 142 ILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEAS 201 Query: 259 ----RSDVYSFGVLLLEILSG 275 R D++S GV+L +LSG Sbjct: 202 IYDKRCDLWSLGVILYILLSG 222 >4X7Q-B nrPDB Length = 312 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 77/321 (23%), Positives = 137/321 (42%), Gaps = 69/321 (21%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE---GFQGHREWLT-- 120 +R ++G+GGFG VF G LT L +A+K + + G+ + +T Sbjct: 32 EYRLGPLLGKGGFGTVFAG----HRLT-----DRLQVAIKVIPRNRVLGWSPLSDSVTCP 82 Query: 121 -EINYLGQL----SHPNLVKLIGYCLEDEHRLLVYEF-MQKGSLENHLFRRGAYFK-PLP 173 E+ L ++ HP +++L+ + E +LV E + L +++ +G + P Sbjct: 83 LEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSR 142 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN-AKLSDFG---LARDGPM 229 F VA A H V++RDIK NIL+D AKL DFG L D P Sbjct: 143 CFFGQVVA-------AIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPY 195 Query: 230 GDLSYVSTRVMGTYGYAAPEYMSSGHLNA-RSDVYSFGVLLLEILSGKRALDHNRPAKEE 288 D GT Y+ PE++S +A + V+S G+LL +++ G + ++ E Sbjct: 196 TDFD-------GTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEA 248 Query: 289 NLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 L + + ++ +CL+ +P SRP++++++ Sbjct: 249 EL------------------------HFPAHVSPDCCALIRRCLAPKPSSRPSLEEIL-- 282 Query: 349 LQQLQDNLGKPSQTNPVKDTK 369 L + P++ P+ +K Sbjct: 283 ---LDPWMQTPAEDVPLNPSK 300 >6E2O-A nrPDB Length = 295 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 52/209 (24%), Positives = 97/209 (46%), Gaps = 19/209 (9%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 V+G+G +G V+ G + IA+K++ + + + EI L H Sbjct: 29 VLGKGTYGIVYAG---------RDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHK 79 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 N+V+ +G E+ + E + GSL L + K + +GL +L Sbjct: 80 NIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTK-QILEGLKYL 138 Query: 192 HSDPVKVIYRDIKASNILLDADYNA--KLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPE 249 H + ++++RDIK N+L++ Y+ K+SDFG ++ + ++ + GT Y APE Sbjct: 139 HDN--QIVHRDIKGDNVLINT-YSGVLKISDFGTSKR--LAGINPCTETFTGTLQYMAPE 193 Query: 250 YMSSG--HLNARSDVYSFGVLLLEILSGK 276 + G +D++S G ++E+ +GK Sbjct: 194 IIDKGPRGYGKAADIWSLGCTIIEMATGK 222 >2V7O-A nrPDB Length = 336 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 58/233 (24%), Positives = 101/233 (43%), Gaps = 29/233 (12%) Query: 53 KSFTFNELKLATR---NFRPDSVIGEGGFG----CVFKGWLDESTLTPTKPGTGLVIAVK 105 ++ F + TR +++ +G+G F CV K TPT+ +I K Sbjct: 16 ENLYFQSMATCTRFTDDYQLFEELGKGAFSVVRRCVKK--------TPTQEYAAKIINTK 67 Query: 106 KLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR 165 KL+ + H++ E L HPN+V+L E+ LV++ + G L + R Sbjct: 68 KLSA---RDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAR 124 Query: 166 GAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN---AKLSDFG 222 Y+ ++ L++ H +++RD+K N+LL + KL+DFG Sbjct: 125 -EYYSEADASHCIHQILESVN-----HIHQHDIVHRDLKPENLLLASKCKGAAVKLADFG 178 Query: 223 LARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 LA + ++ GT GY +PE + D+++ GV+L +L G Sbjct: 179 LAIEVQGEQQAWFG--FAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVG 229 >4IC8-A nrPDB Length = 442 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 34/96 (35%), Positives = 57/96 (59%), Gaps = 7/96 (7%) Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR---DGPMGDLSYVSTRVMGT 242 +GL ++HS +VI+RD+K SN+L++ + K+ DFG+AR P + Y T + T Sbjct: 170 RGLKYMHS--AQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSP-AEHQYFMTEYVAT 226 Query: 243 YGYAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKR 277 Y APE M S H ++ D++S G + E+L+ ++ Sbjct: 227 RWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQ 262 >4JLC-A nrPDB Length = 657 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 67/222 (30%), Positives = 97/222 (43%), Gaps = 36/222 (16%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYLGQLSH 130 ++G+G VF+G TG + AVK N F + + E L +L+H Sbjct: 15 ILGQGATANVFRG---------RHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNH 65 Query: 131 PNLVKLIGYCLEDE----HRLLVYEFMQKGSLENHLFR-RGAYFKPLPWFLRVNVALDAA 185 N+VKL + +E+E H++L+ EF GSL L AY P FL V D Sbjct: 66 KNIVKL--FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLI--VLRDVV 121 Query: 186 KGLAFLHSDPVKVIYRDIKASNILL----DADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 G+ L + +++RDIK NI+ D KL+DFG AR+ D +VS + G Sbjct: 122 GGMNHLRENG--IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVS--LYG 176 Query: 242 TYGYAAPEYMSSGHLN--------ARSDVYSFGVLLLEILSG 275 T Y P+ L A D++S GV +G Sbjct: 177 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATG 218 >4ZSG-A nrPDB Length = 347 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 34/96 (35%), Positives = 57/96 (59%), Gaps = 7/96 (7%) Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR---DGPMGDLSYVSTRVMGT 242 +GL ++HS +VI+RD+K SN+L++ + K+ DFG+AR P + Y T + T Sbjct: 122 RGLKYMHS--AQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSP-AEHQYFMTEYVAT 178 Query: 243 YGYAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKR 277 Y APE M S H ++ D++S G + E+L+ ++ Sbjct: 179 RWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQ 214 >2H34-A nrPDB Length = 309 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 87/213 (40%), Gaps = 21/213 (9%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT----EI 122 +R ++G GG G V++ E T+ I KL E + T E Sbjct: 36 YRLRRLVGRGGMGDVYEA---EDTVRER-------IVALKLMSETLSSDPVFRTRMQREA 85 Query: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 G+L P++V + + D + + L L R+G P VA+ Sbjct: 86 RTAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPR------AVAI 139 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 G A + +RD+K NIL+ AD A L DFG+A L+ + V GT Sbjct: 140 VRQIGSALDAAHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTV-GT 198 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 Y APE S H R+D+Y+ +L E L+G Sbjct: 199 LYYMAPERFSESHATYRADIYALTCVLYECLTG 231 >4NST-A nrPDB Length = 351 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 66/234 (28%), Positives = 100/234 (42%), Gaps = 49/234 (20%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL----NQEGFQGHREWLTEINYLGQ 127 +IGEG +G V+K TG ++A+KK+ +EGF + EI L Q Sbjct: 20 IIGEGTYGQVYKA---------KDKDTGELVALKKVRLDNEKEGFPITA--IREIKILRQ 68 Query: 128 LSHPNLVKLIGYCLEDEHRL----------LVYEFMQK---GSLENHLFRRG-----AYF 169 L H ++V + + + L LV+E+M G LE+ L ++ Sbjct: 69 LIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFM 128 Query: 170 KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPM 229 K L +GL + H ++RDIK SNILL+ KL+DFGLAR Sbjct: 129 KQL------------MEGLEYCHKK--NFLHRDIKCSNILLNNSGQIKLADFGLARLYNS 174 Query: 230 GDLSYVSTRVMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRALDHN 282 + + +V+ T Y PE + DV+S G +L E+ + K N Sbjct: 175 EESRPYTNKVI-TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 227 >3KK8-A nrPDB Length = 284 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 57/218 (26%), Positives = 95/218 (43%), Gaps = 29/218 (13%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGL-----VIAVKKLNQEGFQGHREWLT 120 N+ +G+G F V + TGL +I KKL+ FQ Sbjct: 7 NYDVKEELGKGAFSVVRRC---------VHKTTGLEFAAKIINTKKLSARDFQKLER--- 54 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 E +L HPN+V+L E+ LV++ + G L + R Y + + Sbjct: 55 EARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADA----SHC 110 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN---AKLSDFGLARDGPMGDLSYVST 237 + +A+ HS+ +++R++K N+LL + KL+DFGLA + + D S Sbjct: 111 IQQILESIAYCHSN--GIVHRNLKPENLLLASKAKGAAVKLADFGLAIE--VND-SEAWH 165 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 GT GY +PE + + D+++ GV+L +L G Sbjct: 166 GFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVG 203 >4NIF-A nrPDB Length = 333 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 52/188 (27%), Positives = 88/188 (46%), Gaps = 25/188 (13%) Query: 97 GTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKG 156 T + AVK +++ E + Y GQ HPN++ L + +H LV E M+ G Sbjct: 31 ATNMEYAVKVIDKSKRDPSEEIEILLRY-GQ--HPNIITLKDVYDDGKHVYLVTELMRGG 87 Query: 157 SLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNIL-LDADYN 215 L + + R+ + + F+ + K + +LHS V++RD+K SNIL +D N Sbjct: 88 ELLDKILRQKFFSEREASFVLHTIG----KTVEYLHSQ--GVVHRDLKPSNILYVDESGN 141 Query: 216 A---KLSDFGLAR-----DGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGV 267 ++ DFG A+ +G + Y T + APE + + D++S G+ Sbjct: 142 PECLRICDFGFAKQLRAENGLLMTPCY-------TANFVAPEVLKRQGYDEGCDIWSLGI 194 Query: 268 LLLEILSG 275 LL +L+G Sbjct: 195 LLYTMLAG 202 >4C0T-A nrPDB Length = 974 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 58/232 (25%), Positives = 103/232 (44%), Gaps = 29/232 (12%) Query: 59 ELKLATRN---FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH 115 E+K RN F+ +GEG + V + T TG AVK L++ Sbjct: 257 EMKTIRRNVTDFKFGKELGEGSYSTV---------ILATDKITGKQYAVKVLDKRHIIKE 307 Query: 116 REWL---TEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKP 171 ++ E + L +LS+ V + + +D+ L V ++ G L + R + Sbjct: 308 KKVKYVNIEKHALNRLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEE 367 Query: 172 LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR------ 225 + LDA K ++H + VI+RD+K NILLD +++DFG AR Sbjct: 368 CTRHFGAQI-LDAIK---YMHDN--GVIHRDLKPENILLDDKMRIQITDFGTARLLEKKN 421 Query: 226 -DGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 + + + +GT Y +PE + + + DV++FG ++ ++++GK Sbjct: 422 DESEEYPVDVRAKSFVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGK 473 >6NT9-A nrPDB Length = 742 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 97/222 (43%), Gaps = 36/222 (16%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYLGQLSH 130 ++G+G VF+G TG + A+K N F + + E L +L+H Sbjct: 14 ILGQGATANVFRG---------RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH 64 Query: 131 PNLVKLIGYCLEDE----HRLLVYEFMQKGSLENHLFR-RGAYFKPLPWFLRVNVALDAA 185 N+VKL + +E+E H++L+ EF GSL L AY P FL V D Sbjct: 65 KNIVKL--FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLI--VLRDVV 120 Query: 186 KGLAFLHSDPVKVIYRDIKASNILL----DADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 G+ L + +++R+IK NI+ D KL+DFG AR+ D +VS + G Sbjct: 121 GGMNHLREN--GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVS--LYG 175 Query: 242 TYGYAAPEYMSSGHLN--------ARSDVYSFGVLLLEILSG 275 T Y P+ L A D++S GV +G Sbjct: 176 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATG 217 >3BHH-A nrPDB Length = 295 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 89/213 (41%), Gaps = 32/213 (15%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG--HREWLTEINYLGQLSH 130 IG+G F V + K TG A K +N + H++ E L H Sbjct: 12 IGKGAFSVVRRC---------VKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKH 62 Query: 131 PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL-- 188 N+V+L E+ LV++ + G L + R Y + DA+ + Sbjct: 63 SNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEA-----------DASHCIQQ 111 Query: 189 ---AFLHSDPVKVIYRDIKASNILLDADYN---AKLSDFGLARDGPMGDLSYVSTRVMGT 242 A LH + V++RD+K N+LL + KL+DFGLA + ++ GT Sbjct: 112 ILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFG--FAGT 169 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 GY +PE + D+++ GV+L +L G Sbjct: 170 PGYLSPEVLRKEAYGKPVDIWACGVILYILLVG 202 >5FG8-A nrPDB Length = 285 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 49/183 (26%), Positives = 79/183 (43%), Gaps = 24/183 (13%) Query: 101 VIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLEN 160 +I KKL FQ E +L HPN+V+L E+ + LV++ + G L Sbjct: 46 IINTKKLTARDFQKLER---EARICRKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFE 102 Query: 161 HLFRRGAYFKPLPWFLRVNVALDAAKGLAFL-----HSDPVKVIYRDIKASNILLDADYN 215 + R Y + DA+ + + H V++RD+K N+LL + Sbjct: 103 DIVAREFYSEA-----------DASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAK 151 Query: 216 ---AKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEI 272 KL+DFGLA + ++ GT GY +PE + D+++ GV+L + Sbjct: 152 GAAVKLADFGLAIEVQGDHQAWFG--FAGTPGYLSPEVLKKEPYGKSVDIWACGVILYIL 209 Query: 273 LSG 275 L G Sbjct: 210 LVG 212 >3MIA-A nrPDB Length = 351 Score = 55.1 bits (131), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 57/168 (33%), Positives = 78/168 (46%), Gaps = 35/168 (20%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL----NQEGFQGHREWLTEINYLGQL 128 IG+G FG VFK TG +A+KK+ +EGF L EI L L Sbjct: 25 IGQGTFGEVFKA---------RHRKTGQKVALKKVLMENEKEGFPITA--LREIKILQLL 73 Query: 129 SHPNLVKLIGYCLEDEHRL--------LVYEFMQK---GSLENHLFRRGAYFKPLPWFLR 177 H N+V LI C LV++F + G L N L + L R Sbjct: 74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFT-----LSEIKR 128 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR 225 V L GL ++H + K+++RD+KA+N+L+ D KL+DFGLAR Sbjct: 129 VMQML--LNGLYYIHRN--KILHRDMKAANVLITRDGVLKLADFGLAR 172 >1KOA-A nrPDB Length = 491 Score = 55.1 bits (131), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 58/206 (28%), Positives = 83/206 (40%), Gaps = 21/206 (10%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +G G FG V + T+ TG A K + EI + L HP Sbjct: 59 LGTGAFGVVHRV---------TERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRHPT 109 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGA-YFKPLPWFLRVNVALDAAKGLAFL 191 LV L +D +++YEFM G LF + A + V KGL + Sbjct: 110 LVNLHDAFEDDNEMVMIYEFMSGGE----LFEKVADEHNKMSEDEAVEYMRQVCKGLCHM 165 Query: 192 HSDPVKVIYRDIKASNILLDADYNA--KLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPE 249 H + ++ D+K NI+ + KL DFGL V+T GT +AAPE Sbjct: 166 HEN--NYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTT---GTAEFAAPE 220 Query: 250 YMSSGHLNARSDVYSFGVLLLEILSG 275 + +D++S GVL +LSG Sbjct: 221 VAEGKPVGYYTDMWSVGVLSYILLSG 246 >3MDY-A nrPDB Length = 337 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 78/312 (25%), Positives = 139/312 (44%), Gaps = 53/312 (16%) Query: 73 IGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKL-NQEGFQGHREWLTEINYLGQLSH 130 IG+G +G V+ G W E +AVK E RE TEI + H Sbjct: 45 IGKGRYGEVWMGKWRGEK------------VAVKVFFTTEEASWFRE--TEIYQTVLMRH 90 Query: 131 PNLVKLIGYCLEDE----HRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAK 186 N++ I ++ L+ ++ + GSL ++L K + + +A + Sbjct: 91 ENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSM-----LKLAYSSVS 145 Query: 187 GLAFLHSDPVK------VIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV----S 236 GL LH++ + +RD+K+ NIL+ + ++D GLA + D + V + Sbjct: 146 GLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKF-ISDTNEVDIPPN 204 Query: 237 TRVMGTYGYAAPEY----MSSGHLNA--RSDVYSFGVLLLEI----LSGKRALDHNRPAK 286 TRV GT Y PE ++ H + +D+YSFG++L E+ +SG ++ P Sbjct: 205 TRV-GTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPY- 262 Query: 287 EENLVDWARPYLTSKRKVLLIVDNR--LDTQYLPEEAVR-MASVAVQCLSFEPKSRPTMD 343 +LV + P R+++ I R ++ +E +R M + +C + P SR T Sbjct: 263 -HDLVP-SDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTAL 320 Query: 344 QVVRALQQLQDN 355 +V + L ++ ++ Sbjct: 321 RVKKTLAKMSES 332 >4AW2-A nrPDB Length = 437 Score = 54.3 bits (129), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 64/248 (25%), Positives = 105/248 (42%), Gaps = 53/248 (21%) Query: 53 KSFT--FNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE 110 K FT +++L +F VIG G FG E + K V A+K LN+ Sbjct: 60 KPFTSKVKQMRLHREDFEILKVIGRGAFG--------EVAVVKLK-NADKVFAMKILNKW 110 Query: 111 GF-----------------QGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFM 153 G +W+T ++Y Q + NL ++ Y + + L+ +F Sbjct: 111 EMLKRAETACFREERDVLVNGDSKWITTLHYAFQDDN-NLYLVMDYYVGGDLLTLLSKF- 168 Query: 154 QKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD 213 E+ L A F + + +A+D+ L ++H RDIK NIL+D + Sbjct: 169 -----EDRLPEEMARF----YLAEMVIAIDSVHQLHYVH--------RDIKPDNILMDMN 211 Query: 214 YNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSS-----GHLNARSDVYSFGVL 268 + +L+DFG M D + S+ +GT Y +PE + + G D +S GV Sbjct: 212 GHIRLADFGSCLK-LMEDGTVQSSVAVGTPDYISPEILQAMEGGKGRYGPECDWWSLGVC 270 Query: 269 LLEILSGK 276 + E+L G+ Sbjct: 271 MYEMLYGE 278 >3UTO-A nrPDB Length = 573 Score = 54.3 bits (129), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 58/206 (28%), Positives = 83/206 (40%), Gaps = 21/206 (10%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +G G FG V + T+ TG A K + EI + L HP Sbjct: 165 LGTGAFGVVHRV---------TERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRHPT 215 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGA-YFKPLPWFLRVNVALDAAKGLAFL 191 LV L +D +++YEFM G LF + A + V KGL + Sbjct: 216 LVNLHDAFEDDNEMVMIYEFMSGGE----LFEKVADEHNKMSEDEAVEYMRQVCKGLCHM 271 Query: 192 HSDPVKVIYRDIKASNILLDADYNA--KLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPE 249 H + ++ D+K NI+ + KL DFGL V+T GT +AAPE Sbjct: 272 HEN--NYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTT---GTAEFAAPE 326 Query: 250 YMSSGHLNARSDVYSFGVLLLEILSG 275 + +D++S GVL +LSG Sbjct: 327 VAEGKPVGYYTDMWSVGVLSYILLSG 352 >4EUT-A nrPDB Length = 396 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 97/222 (43%), Gaps = 36/222 (16%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYLGQLSH 130 ++G+G VF+G TG + A+K N F + + E L +L+H Sbjct: 16 ILGQGATANVFRG---------RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH 66 Query: 131 PNLVKLIGYCLEDE----HRLLVYEFMQKGSLENHLFR-RGAYFKPLPWFLRVNVALDAA 185 N+VKL + +E+E H++L+ EF GSL L AY P FL V D Sbjct: 67 KNIVKL--FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLI--VLRDVV 122 Query: 186 KGLAFLHSDPVKVIYRDIKASNILL----DADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 G+ L + +++R+IK NI+ D KL+DFG AR+ D +VS + G Sbjct: 123 GGMNHLREN--GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVS--LYG 177 Query: 242 TYGYAAPEYMSSGHL--------NARSDVYSFGVLLLEILSG 275 T Y P+ L A D++S GV +G Sbjct: 178 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATG 219 >6BXI-A nrPDB Length = 333 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 70/261 (26%), Positives = 107/261 (40%), Gaps = 71/261 (27%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEG--------- 111 +L +F VIG G FG E L K TG V A+K L + Sbjct: 2 RLGLEDFESLKVIGRGAFG--------EVRLV-QKKDTGHVYAMKILRKADMLEKEQVGH 52 Query: 112 FQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFK 170 + R+ L E + L +VK+ Y +D+ L L+ EF+ G + L ++ + Sbjct: 53 IRAERDILVEADSLW------VVKMF-YSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTE 105 Query: 171 PLPWFL--RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLA---- 224 F +A+D+ L F+H RDIK N+LLD+ + KLSDFGL Sbjct: 106 EETQFYIAETVLAIDSIHQLGFIH--------RDIKPDNLLLDSKGHVKLSDFGLCTGLK 157 Query: 225 ---RDGPMGDLSY--------------------------VSTRVMGTYGYAAPE-YMSSG 254 R +L++ ++ +GT Y APE +M +G Sbjct: 158 KAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG 217 Query: 255 HLNARSDVYSFGVLLLEILSG 275 + N D +S GV++ E+L G Sbjct: 218 Y-NKLCDWWSLGVIMYEMLIG 237 >3MY0-A nrPDB Length = 305 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 63/231 (27%), Positives = 98/231 (42%), Gaps = 59/231 (25%) Query: 72 VIGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQEGFQG-HREWLTEINYLGQLS 129 +G+G +G V++G W ES +AVK + Q RE TEI L Sbjct: 15 CVGKGRYGEVWRGLWHGES------------VAVKIFSSRDEQSWFRE--TEIYNTVLLR 60 Query: 130 HPNLVKLIGYCLED--------------EHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 H N++ I + EH L Y+F+Q+ +LE HL R Sbjct: 61 HDNILGFIASDMTSRNSSTQLWLITHYHEHGSL-YDFLQRQTLEPHLALR---------- 109 Query: 176 LRVNVALDAAKGLAFLHSDPV------KVIYRDIKASNILLDADYNAKLSDFGLARDGPM 229 +A+ AA GLA LH + + +RD K+ N+L+ ++ ++D GLA Sbjct: 110 ----LAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQ 165 Query: 230 GD--LSYVSTRVMGTYGYAAPEYMSSG------HLNARSDVYSFGVLLLEI 272 G L + +GT Y APE + +D+++FG++L EI Sbjct: 166 GSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEI 216 >2PMN-X nrPDB Length = 348 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 40/132 (30%), Positives = 68/132 (51%), Gaps = 19/132 (14%) Query: 148 LVYEFMQKGSLENHLFRRGAYF----KPLPWFLRVNVALDAAKGL----AFLHSDPVKVI 199 ++YE+M+ S+ + YF K F+ + V K + +++H++ + Sbjct: 120 IIYEYMENDSI----LKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEK-NIC 174 Query: 200 YRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMS--SGHLN 257 +RD+K SNIL+D + KLSDFG + M D +R GTY + PE+ S S + Sbjct: 175 HRDVKPSNILMDKNGRVKLSDFGESE--YMVDKKIKGSR--GTYEFMPPEFFSNESSYNG 230 Query: 258 ARSDVYSFGVLL 269 A+ D++S G+ L Sbjct: 231 AKVDIWSLGICL 242 >5WAX-A nrPDB Length = 310 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 88/206 (42%), Gaps = 22/206 (10%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IG G FG + L + G ++AVK + + G + EI L HPN Sbjct: 19 IGSGNFGV--------ARLMRNR-ADGQLVAVKYI-ERGEKIDENVQREIINHRSLRHPN 68 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 +++ L H +V E+ G L + G + + F + G+++ H Sbjct: 69 IIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQL----ISGVSYCH 124 Query: 193 SDPVKVIYRDIKASNILLDADY--NAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEY 250 S ++V +RD+K N LLD K+ DFG ++ L +GT Y APE Sbjct: 125 S--MQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSV---LHSQPKSTVGTPAYIAPEV 179 Query: 251 MSSGHLNAR-SDVYSFGVLLLEILSG 275 + + + +DV+S GV L +L G Sbjct: 180 LLKKEYDGKVADVWSCGVTLYVMLVG 205 >2J90-A nrPDB Length = 304 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 69/288 (23%), Positives = 115/288 (39%), Gaps = 54/288 (18%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT------EINYLG 126 +G G F V K + GTG A K + + R ++ E+N L Sbjct: 34 LGSGQFAIVRKC---------RQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILR 84 Query: 127 QLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFK-PLPWFLRVNVALDAA 185 ++ HPN++ L +L+ E + G L + L + + + FL+ Sbjct: 85 EIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLK-----QIL 139 Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNA-----KLSDFGLARDGPMGDLSYVSTRVM 240 G+ +LHS ++ + D+K NI+L D N KL DFG+A G+ + Sbjct: 140 DGVHYLHSK--RIAHFDLKPENIML-LDKNVPNPRIKLIDFGIAHKIEAGN---EFKNIF 193 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 GT + APE ++ L +D++S GV+ +LSG A P+L Sbjct: 194 GTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSG------------------ASPFLGE 235 Query: 301 KRKVLLI----VDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQ 344 ++ L V+ D +Y + + L +PK R T+ Q Sbjct: 236 TKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQ 283 >5LOH-A nrPDB Length = 341 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 73/262 (27%), Positives = 113/262 (43%), Gaps = 47/262 (17%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGL--VIAVKKLNQEGFQGHREWLTEINYLGQLSH 130 I G FG V+ G + G L V VKK + + E + L Sbjct: 44 ISRGAFGKVYLG----------QKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKS 93 Query: 131 PNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 P +V L Y L+ + + LV E++ G +++ L G YF + V + A L Sbjct: 94 PFIVHLY-YSLQSANNVYLVMEYLIGGDVKSLLHIYG-YFDEE---MAVKYISEVALALD 148 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLA-----RDGPMGDLSYVSTRVM-GTY 243 +LH +I+RD+K N+L+ + + KL+DFGL+ RD M D+ ++TR GT Sbjct: 149 YLHRH--GIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDI--LTTRTFCGTP 204 Query: 244 GYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK---------------EE 288 Y APE + D ++ GV L E L+G + P + EE Sbjct: 205 DYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEE 264 Query: 289 NLVDWARPYLTSKRKVLLIVDN 310 L D A+ S ++LL +D+ Sbjct: 265 KLSDNAQ----SAVEILLTIDD 282 >4EUU-A nrPDB Length = 319 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 97/222 (43%), Gaps = 36/222 (16%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYLGQLSH 130 ++G+G VF+G TG + A+K N F + + E L +L+H Sbjct: 16 ILGQGATANVFRG---------RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH 66 Query: 131 PNLVKLIGYCLEDE----HRLLVYEFMQKGSLENHLFR-RGAYFKPLPWFLRVNVALDAA 185 N+VKL + +E+E H++L+ EF GSL L AY P FL V D Sbjct: 67 KNIVKL--FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLI--VLRDVV 122 Query: 186 KGLAFLHSDPVKVIYRDIKASNILL----DADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 G+ L + +++R+IK NI+ D KL+DFG AR+ D +VS + G Sbjct: 123 GGMNHLREN--GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARE-LEDDEQFVS--LYG 177 Query: 242 TYGYAAPEYMSSGHL--------NARSDVYSFGVLLLEILSG 275 T Y P+ L A D++S GV +G Sbjct: 178 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATG 219 >3FME-A nrPDB Length = 290 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 69/298 (23%), Positives = 125/298 (41%), Gaps = 43/298 (14%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE-GFQGHREW 118 +++ + P +G G +G V ++ P+ G ++AVK++ Q + Sbjct: 2 MEVKADDLEPIMELGRGAYGVV-----EKMRHVPS----GQIMAVKRIRATVNSQEQKRL 52 Query: 119 LTEINY-LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 L +++ + + P V G + + E M SL+ + + +P + Sbjct: 53 LMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDIL 111 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLA---RDGPMGDLSY 234 +A+ K L LHS + VI+RD+K SN+L++A K+ DFG++ D D+ Sbjct: 112 GKIAVSIVKALEHLHSK-LSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDID- 169 Query: 235 VSTRVMGTYGYAAPEYMSSGHLN-----ARSDVYSFGVLLLEILSGKRALDHNRPAKEEN 289 G Y APE ++ LN +SD++S G+ ++E+ + D Sbjct: 170 -----AGCKPYMAPERINP-ELNQKGYSVKSDIWSLGITMIELAILRFPYDS-------- 215 Query: 290 LVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 W P+ K+ V+ +L E V S QCL K RPT ++++ Sbjct: 216 ---WGTPFQQLKQ-VVEEPSPQLPADKFSAEFVDFTS---QCLKKNSKERPTYPELMQ 266 >6O8B-A nrPDB Length = 665 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 64/222 (28%), Positives = 96/222 (43%), Gaps = 36/222 (16%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYLGQLSH 130 ++G+G VF+G TG + A+K N F + + E L +L+H Sbjct: 22 ILGQGATANVFRG---------RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNH 72 Query: 131 PNLVKLIGYCLEDE----HRLLVYEFMQKGSLENHLFR-RGAYFKPLPWFLRVNVALDAA 185 N+VKL + +E+E H++L+ EF GSL L AY P FL V D Sbjct: 73 KNIVKL--FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLI--VLRDVV 128 Query: 186 KGLAFLHSDPVKVIYRDIKASNILL----DADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 G+ L + +++R+IK NI+ D KL+DFG AR+ D +V + G Sbjct: 129 GGMNHLREN--GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELE-DDEQFVE--LYG 183 Query: 242 TYGYAAPEYMSSGHLN--------ARSDVYSFGVLLLEILSG 275 T Y P+ L A D++S GV +G Sbjct: 184 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATG 225 >4PL5-B nrPDB Length = 435 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 58/222 (26%), Positives = 101/222 (45%), Gaps = 35/222 (15%) Query: 66 NFRPDSVIGEGGFG-CVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 +F P V+G G G V+KG D +AVK++ E F E+ Sbjct: 28 SFCPKDVLGHGAEGTIVYKGMFDNRD-----------VAVKRILPECFSFADR---EVQL 73 Query: 125 LGQL-SHPNLVKLIGYCLEDEHRLLVYEF-MQKGSLENHLFRRG-AYFKPLPWFLRVNVA 181 L + HPN+++ +C E + + + +L+ ++ ++ A+ P + + Sbjct: 74 LRESDEHPNVIRY--FCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEP----ITLL 127 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLD-----ADYNAKLSDFGLARDGPMGDLSYV- 235 GLA LHS + +++RD+K NILL A +SDFGL + +G S+ Sbjct: 128 HQTTSGLAHLHS--LNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSR 185 Query: 236 STRVMGTYGYAAPEYMSSGHLNARS---DVYSFGVLLLEILS 274 + V GT G+ APE +S + + D++S G + ++S Sbjct: 186 RSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVIS 227 >5AWM-A nrPDB Length = 394 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 31/89 (34%), Positives = 49/89 (55%), Gaps = 5/89 (5%) Query: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYA 246 G+ LHS +I+RD+K SNI++ AD K+ DFGLAR +++ T + T Y Sbjct: 158 GIKHLHS--AGIIHRDLKPSNIVVKADCTLKILDFGLAR---TAGTTFMMTPYVVTRYYR 212 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSG 275 APE + D++S G ++ E++ G Sbjct: 213 APEVILGMGYTENVDIWSVGCIMGEMIRG 241 >3F3Z-A nrPDB Length = 277 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 88/209 (42%), Gaps = 22/209 (10%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLS 129 ++ IG G +G V + GT + A KK+ + + + EI + L Sbjct: 14 ENTIGRGSWGEV---------KIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMKSLD 64 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 HPN+++L ++ LV E G LF R + + + D +A Sbjct: 65 HPNIIRLYETFEDNTDIYLVMELCTGG----ELFERVVHKRVFRESDAARIMKDVLSAVA 120 Query: 190 FLHSDPVKVIYRDIKASNILL---DADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYA 246 + H + V +RD+K N L D KL DFGLA G + + T+V GT Y Sbjct: 121 YCHK--LNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKM--MRTKV-GTPYYV 175 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSG 275 +P+ + G D +S GV++ +L G Sbjct: 176 SPQVL-EGLYGPECDEWSAGVMMYVLLCG 203 >3TKU-A nrPDB Length = 433 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 66/256 (25%), Positives = 103/256 (40%), Gaps = 69/256 (26%) Query: 53 KSFT--FNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE 110 K FT E++L +F VIG G FG E + K T + A+K LN+ Sbjct: 76 KPFTQLVKEMQLHREDFEIIKVIGRGAFG--------EVAVVKMK-NTERIYAMKILNKW 126 Query: 111 GF-----------------QGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFM 153 G +W+T ++Y Q ++ H LV ++ Sbjct: 127 EMLKRAETACFREERDVLVNGDCQWITALHYAFQ--------------DENHLYLVMDYY 172 Query: 154 QKGSL-------ENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKAS 206 G L E+ L A F + + +A+D+ L ++H RDIK Sbjct: 173 VGGDLLTLLSKFEDKLPEDMARF----YIGEMVLAIDSIHQLHYVH--------RDIKPD 220 Query: 207 NILLDADYNAKLSDFGLARDGPMGDLSYVSTRV-MGTYGYAAPEYMSS-----GHLNARS 260 N+LLD + + +L+DFG M D V + V +GT Y +PE + + G Sbjct: 221 NVLLDVNGHIRLADFGSCL--KMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPEC 278 Query: 261 DVYSFGVLLLEILSGK 276 D +S GV + E+L G+ Sbjct: 279 DWWSLGVCMYEMLYGE 294 >2YAB-A nrPDB Length = 361 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 95/213 (44%), Gaps = 28/213 (13%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR------EWLTEINYLG 126 +G G F V K + TGL A K + + + R E E++ L Sbjct: 20 LGSGQFAIVKKC---------REKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILR 70 Query: 127 QLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAK 186 Q+ HPN++ L +L+ E + G L + L ++ + + + LD Sbjct: 71 QVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSF-IKQILD--- 126 Query: 187 GLAFLHSDPVKVIYRDIKASNI-LLDADY---NAKLSDFGLARDGPMGDLSYVSTRVMGT 242 G+ +LH+ K+ + D+K NI LLD + + KL DFGLA + G + GT Sbjct: 127 GVNYLHTK--KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDG---VEFKNIFGT 181 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 + APE ++ L +D++S GV+ +LSG Sbjct: 182 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSG 214 >4C59-A nrPDB Length = 340 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 57/236 (24%), Positives = 98/236 (41%), Gaps = 31/236 (13%) Query: 55 FTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG 114 F ++L R V+ EGGF V++ G+G A+K+L + Sbjct: 17 FVGQTVELGELRLRVRRVLAEGGFAFVYEA---------QDVGSGREYALKRLLSNEEEK 67 Query: 115 HREWLTEINYLGQLS-HPNLVKL-----IGYCLED--EHRLLVYEFMQKGSLENHLFRRG 166 +R + E+ ++ +LS HPN+V+ IG D + L+ + KG L L ++ Sbjct: 68 NRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFL-KKM 126 Query: 167 AYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD 226 PL + + + + +H +I+RD+K N+LL KL DFG A Sbjct: 127 ESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATT 186 Query: 227 -GPMGDLSYVSTRVM---------GTYGYAAPEYM---SSGHLNARSDVYSFGVLL 269 D S+ + R T Y PE + S+ + + D+++ G +L Sbjct: 187 ISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCIL 242 >2HW6-A nrPDB Length = 307 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 50/187 (26%), Positives = 88/187 (47%), Gaps = 20/187 (10%) Query: 103 AVKKLNQEGFQGHREWLTEINYLGQLS-HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENH 161 AVK + ++ E+ L Q + N+++LI + +D LV+E +Q GS+ H Sbjct: 42 AVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAH 101 Query: 162 LFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN---AKL 218 + ++ +F V D A L FLH+ + +RD+K NIL ++ K+ Sbjct: 102 I-QKQKHFNERE---ASRVVRDVAAALDFLHTK--GIAHRDLKPENILCESPEKVSPVKI 155 Query: 219 SDFGLARDGPMGD-LSYVSTRVM----GTYGYAAPEYMS-----SGHLNARSDVYSFGVL 268 DF L + + + ++T + G+ Y APE + + + R D++S GV+ Sbjct: 156 CDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVV 215 Query: 269 LLEILSG 275 L +LSG Sbjct: 216 LYIMLSG 222 >4JG6-A nrPDB Length = 355 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 53/191 (27%), Positives = 89/191 (46%), Gaps = 31/191 (16%) Query: 97 GTGLVIAVKKLNQEGFQGHREWLTEINYL---GQLSHPNLVKLIGYCLEDEHRLLVYEFM 153 T + AVK +++ R+ EI L GQ HPN++ L + ++ +V E M Sbjct: 58 ATNMEFAVKIIDK----SKRDPTEEIEILLRYGQ--HPNIITLKDVYDDGKYVYVVTELM 111 Query: 154 QKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNIL-LDA 212 + G L + + R+ + + V K + +LH+ V++RD+K SNIL +D Sbjct: 112 KGGELLDKILRQKFFSEREA----SAVLFTITKTVEYLHAQ--GVVHRDLKPSNILYVDE 165 Query: 213 DYN---AKLSDFGLAR-----DGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYS 264 N ++ DFG A+ +G + Y T + APE + +A D++S Sbjct: 166 SGNPESIRICDFGFAKQLRAENGLLMTPCY-------TANFVAPEVLERQGYDAACDIWS 218 Query: 265 FGVLLLEILSG 275 GVLL +L+G Sbjct: 219 LGVLLYTMLTG 229 >5IKW-A nrPDB Length = 310 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 52/215 (24%), Positives = 91/215 (42%), Gaps = 27/215 (12%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLS-HP 131 + EGGF VF + G+ A+K++ EI + +LS H Sbjct: 22 LAEGGFSTVFL----------VRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHK 71 Query: 132 NLVKLIGYCLEDE-----HRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAK 186 N+V + + L++ E+ + G + N + ++ P L++ D + Sbjct: 72 NIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQI--FCDTCE 129 Query: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD---GPMGDLSYVSTRVMGTY 243 +A LH +I+RD+K NILL+ N L DFG A + P D V + Y Sbjct: 130 AVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKY 189 Query: 244 ---GYAAPEYMS---SGHLNARSDVYSFGVLLLEI 272 Y APE ++ + ++D+++ G LL ++ Sbjct: 190 TTLSYRAPEMINLYGGKPITTKADIWALGCLLYKL 224 >3UC3-A nrPDB Length = 361 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 88/206 (42%), Gaps = 22/206 (10%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IG G FG V + D+ T ++AVK + + G EI L HPN Sbjct: 28 IGSGNFG-VARLMRDKLTKE--------LVAVKYI-ERGAAIDENVQREIINHRSLRHPN 77 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 +V+ L H ++ E+ G L + G + + F + G+++ H Sbjct: 78 IVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQQL----LSGVSYCH 133 Query: 193 SDPVKVIYRDIKASNILLDAD--YNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEY 250 S +++ +RD+K N LLD K+ DFG ++ L +GT Y APE Sbjct: 134 S--MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSV---LHSQPKSTVGTPAYIAPEV 188 Query: 251 MSSGHLNAR-SDVYSFGVLLLEILSG 275 + + + +DV+S GV L +L G Sbjct: 189 LLRQEYDGKIADVWSCGVTLYVMLVG 214 >3E7O-A nrPDB Length = 360 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 63/236 (26%), Positives = 106/236 (44%), Gaps = 35/236 (14%) Query: 49 STPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN 108 S V TF LK + +P IG G G V + ++ L G+ +AVKKL+ Sbjct: 10 SVQVADSTFTVLK-RYQQLKP---IGSGAQGIVCAAF--DTVL-------GINVAVKKLS 56 Query: 109 QEGFQGH---REWLTEINYLGQLSHPNLVKLIGY-----CLED-EHRLLVYEFMQKGSLE 159 + FQ + E+ L ++H N++ L+ LE+ + LV E M + Sbjct: 57 R-PFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQ 115 Query: 160 NHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLS 219 + + + + L + G+ LHS +I+RD+K SNI++ +D K+ Sbjct: 116 --VIHMELDHERMSYLLYQMLC-----GIKHLHS--AGIIHRDLKPSNIVVKSDCTLKIL 166 Query: 220 DFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 DFGLAR +++ T + T Y APE + D++S G ++ E++ G Sbjct: 167 DFGLAR---TASTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKG 219 >2XS0-A nrPDB Length = 386 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 30/89 (33%), Positives = 48/89 (53%), Gaps = 5/89 (5%) Query: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYA 246 G+ LHS +I+RD+K SNI++ +D K+ DFGLAR S++ + T Y Sbjct: 140 GIKHLHS--AGIIHRDLKPSNIVVKSDCTLKILDFGLAR---TAGTSFMMVPFVVTRYYR 194 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSG 275 APE + D++S G ++ E++ G Sbjct: 195 APEVILGMGYKENVDIWSVGCIMGEMIKG 223 >3Q4U-A nrPDB Length = 301 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 69/309 (22%), Positives = 129/309 (41%), Gaps = 51/309 (16%) Query: 72 VIGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL--TEINYLGQL 128 +G+G +G V++G W E+ +AVK + + + W TE+ L Sbjct: 15 CVGKGRYGEVWRGSWQGEN------------VAVKIFSS---RDEKSWFRETELYNTVML 59 Query: 129 SHPNLVKLIGYCLEDEHR----LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 H N++ I + H L+ + + GSL ++L L + + L Sbjct: 60 RHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYL-----QLTTLDTVSCLRIVLSI 114 Query: 185 AKGLAFLHSDPV------KVIYRDIKASNILLDADYNAKLSDFGLA--RDGPMGDLSYVS 236 A GLA LH + + +RD+K+ NIL+ + ++D GLA L + Sbjct: 115 ASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGN 174 Query: 237 TRVMGTYGYAAPEYMSSG-HLNA-----RSDVYSFGVLLLEI----LSGKRALDHNRPAK 286 +GT Y APE + ++ R D+++FG++L E+ +S D+ P Sbjct: 175 NPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFY 234 Query: 287 EENLVDWARPYLTSKRKVLLIVDNR--LDTQYLPEEAV-RMASVAVQCLSFEPKSRPTMD 343 + D P RKV+ + R + ++ + + +A + +C P +R T Sbjct: 235 DVVPND---PSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTAL 291 Query: 344 QVVRALQQL 352 ++ + L ++ Sbjct: 292 RIKKTLTKI 300 >2RIO-A nrPDB Length = 434 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 64/263 (24%), Positives = 114/263 (43%), Gaps = 57/263 (21%) Query: 119 LTEINYLGQLS-HPNLVKLIGYCLEDEHRLL----------VYEFMQKGSLENHLFRRGA 167 L EI L + HPN+++ YC E R L + + ++ ++ + + Sbjct: 56 LMEIKLLTESDDHPNVIRY--YCSETTDRFLYIALELCNLNLQDLVESKNVSDENLKLQK 113 Query: 168 YFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILL--------DADYNAK-- 217 + P+ ++ A G+A LHS +K+I+RD+K NIL+ D A+ Sbjct: 114 EYNPISLLRQI------ASGVAHLHS--LKIIHRDLKPQNILVSTSSRFTADQQTGAENL 165 Query: 218 ---LSDFGLARDGPMGDLSYVS--TRVMGTYGYAAPEYMSSGH-------LNARSDVYSF 265 +SDFGL + G S+ + GT G+ APE + + L D++S Sbjct: 166 RILISDFGLCKKLDSGQSSFRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSM 225 Query: 266 GVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNR-LDTQYLPEEAVRM 324 G + ILS + ++ ++E N++ R + + + + L + L EA + Sbjct: 226 GCVFYYILSKGKHPFGDKYSRESNII----------RGIFSLDEMKCLHDRSLIAEATDL 275 Query: 325 ASVAVQCLSFEPKSRPTMDQVVR 347 S Q + +P RPT +V+R Sbjct: 276 IS---QMIDHDPLKRPTAMKVLR 295 >3UDB-A nrPDB Length = 317 Score = 51.6 bits (122), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 88/206 (42%), Gaps = 22/206 (10%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IG G FG + L K LV AVK + + G + EI L HPN Sbjct: 27 IGAGNFGV--------ARLMRDKQANELV-AVKYI-ERGEKIDENVKREIINHRSLRHPN 76 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 +V+ L H +V E+ G L + G + + F + G+++ H Sbjct: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQL----ISGVSYAH 132 Query: 193 SDPVKVIYRDIKASNILLDAD--YNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEY 250 + ++V +RD+K N LLD K++DFG ++ L +GT Y APE Sbjct: 133 A--MQVAHRDLKLENTLLDGSPAPRLKIADFGYSK---ASVLHSQPKSAVGTPAYIAPEV 187 Query: 251 MSSGHLNAR-SDVYSFGVLLLEILSG 275 + + + +DV+S GV L +L G Sbjct: 188 LLKKEYDGKVADVWSCGVTLYVMLVG 213 >6HV0-A nrPDB Length = 416 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 62/257 (24%), Positives = 110/257 (42%), Gaps = 53/257 (20%) Query: 66 NFRPDSVIGEGGFG-CVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 +F P V+G G G V++G D +AVK++ E F E+ Sbjct: 9 SFCPKDVLGHGAEGTIVYRGMFDNRD-----------VAVKRILPECFSFADR---EVQL 54 Query: 125 LGQL-SHPNLVKLIGYCLEDEHRLLVYEF-MQKGSLENHLFRRG-AYFKPLPWFLRVNVA 181 L + HPN+++ +C E + + + +L+ ++ ++ A+ P + + Sbjct: 55 LRESDEHPNVIRY--FCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEP----ITLL 108 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLD-----ADYNAKLSDFGLARDGPMGDLSYV- 235 GLA LHS + +++RD+K NIL+ A +SDFGL + +G S+ Sbjct: 109 QQTTSGLAHLHS--LNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSR 166 Query: 236 STRVMGTYGYAAPEYMSSG---HLNARSDVYSFGVLLLEILS------------------ 274 + V GT G+ APE +S + D++S G + ++S Sbjct: 167 RSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILL 226 Query: 275 GKRALDHNRPAKEENLV 291 G +LD P K E+++ Sbjct: 227 GACSLDCLHPEKHEDVI 243 >3TAC-A nrPDB Length = 361 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 56/212 (26%), Positives = 90/212 (42%), Gaps = 21/212 (9%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTE-----INYLG 126 VIG+G F V + E TG AVK ++ F TE + Sbjct: 33 VIGKGPFSVVRRCINRE---------TGQQFAVKIVDVAKFTSSPGLSTEDLKREASICH 83 Query: 127 QLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAK 186 L HP++V+L+ D +V+EFM L + +R + + + Sbjct: 84 MLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILE 143 Query: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNA---KLSDFGLARDGPMGDLSYVSTRVMGTY 243 L + H + +I+RD+K +LL + N+ KL FG+A +G+ V+ +GT Sbjct: 144 ALRYCHDN--NIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQ--LGESGLVAGGRVGTP 199 Query: 244 GYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 + APE + DV+ GV+L +LSG Sbjct: 200 HFMAPEVVKREPYGKPVDVWGCGVILFILLSG 231 >3QD2-B nrPDB Length = 332 Score = 51.2 bits (121), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 48/186 (25%), Positives = 81/186 (43%), Gaps = 45/186 (24%) Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGL--ARD--------- 226 +++ + A+ + FLHS +++RD+K SNI D K+ DFGL A D Sbjct: 167 LHIFIQIAEAVEFLHSK--GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVL 224 Query: 227 GPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK 286 PM + + +V GT Y +PE + + + + D++S G++L E+L Sbjct: 225 TPMPAYATHTGQV-GTKLYMSPEQIHGNNYSHKVDIFSLGLILFELLYS----------- 272 Query: 287 EENLVDWARPYLTSKRKVLLIVDNR------LDTQYLPEEAVRMASVAVQCLSFEPKSRP 340 + T +V +I D R L TQ P+E + + + LS P RP Sbjct: 273 ----------FSTQMERVRIITDVRNLKFPLLFTQKYPQEHMMVQDM----LSPSPTERP 318 Query: 341 TMDQVV 346 ++ Sbjct: 319 EATDII 324 Score = 33.1 bits (74), Expect = 0.22, Method: Compositional matrix adjust. Identities = 23/80 (28%), Positives = 36/80 (45%), Gaps = 14/80 (17%) Query: 66 NFRPDSVIGEGGFGCVF--KGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEI 122 +F P +G GGFG VF K +D+ A+K++ + RE + E+ Sbjct: 7 DFEPIQCMGRGGFGVVFEAKNKVDDCNY-----------AIKRIRLPNRELAREKVMREV 55 Query: 123 NYLGQLSHPNLVKLIGYCLE 142 L +L HP +V+ LE Sbjct: 56 KALAKLEHPGIVRYFNAWLE 75 >1JNK-A nrPDB Length = 423 Score = 50.8 bits (120), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 31/90 (34%), Positives = 49/90 (54%), Gaps = 5/90 (5%) Query: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYA 246 G+ LHS +I+RD+K SNI++ +D K+ DFGLAR S++ T + T Y Sbjct: 176 GIKHLHS--AGIIHRDLKPSNIVVKSDCTLKILDFGLAR---TAGTSFMMTPYVVTRYYR 230 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSGK 276 APE + D++S G ++ E++ K Sbjct: 231 APEVILGMGYKENVDIWSVGCIMGEMVRHK 260 >3FI2-A nrPDB Length = 353 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 31/90 (34%), Positives = 49/90 (54%), Gaps = 5/90 (5%) Query: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYA 246 G+ LHS +I+RD+K SNI++ +D K+ DFGLAR S++ T + T Y Sbjct: 138 GIKHLHS--AGIIHRDLKPSNIVVKSDCTLKILDFGLAR---TAGTSFMMTPYVVTRYYR 192 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSGK 276 APE + D++S G ++ E++ K Sbjct: 193 APEVILGMGYKENVDIWSVGCIMGEMVRHK 222 >6GVJ-A nrPDB Length = 429 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 78/360 (21%), Positives = 151/360 (41%), Gaps = 53/360 (14%) Query: 3 SCFSSRV-KADIFHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNE-L 60 SCF + V K D + S YG ++ + A ++L+S+ + NE + Sbjct: 85 SCFRTPVVKNDFPPACQLSTPYGQPACFQQQQHQILATPLQNLQVLASS-----SANECI 139 Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 + R + IG GG VF+ ++ + K + +++ + + +R + Sbjct: 140 SVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIK-----YVNLEEADNQTLDSYRNEIA 194 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLE-NHLFRRGAYFKPLPWFLRVN 179 +N L Q S +++L Y + D++ +Y M+ G+++ N ++ P + R + Sbjct: 195 YLNKLQQHSD-KIIRLYDYEITDQY---IYMVMECGNIDLNSWLKKKKSIDP---WERKS 247 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 + + + +H +++ D+K +N L+ D KL DFG+A S V Sbjct: 248 YWKNMLEAVHTIHQH--GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQ 304 Query: 240 MGTYGYAAPEY---MSSGHLNA--------RSDVYSFGVLLLEILSGKRALDHNRPAKEE 288 +GT Y PE MSS N +SDV+S G +L + GK Sbjct: 305 VGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQ------- 357 Query: 289 NLVDWARPYLTSKRKVLLIVDNRLDTQY--LPEEAVRMASVAVQCLSFEPKSRPTMDQVV 346 + K+ I+D + ++ +PE+ ++ V CL +PK R ++ +++ Sbjct: 358 --------IINQISKLHAIIDPNHEIEFPDIPEKDLQ--DVLKCCLKRDPKQRISIPELL 407 >4CRL-A nrPDB Length = 406 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 46/169 (27%), Positives = 84/169 (49%), Gaps = 16/169 (9%) Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHR--LLVYEFMQKGSLENHLFRRG--AYFKP--LPW 174 EI L +L HPN++ L L R L++++ + F R A KP LP Sbjct: 69 EIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPR 128 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD----YNAKLSDFGLAR--DGP 228 + ++ G+ +LH++ V++RD+K +NIL+ + K++D G AR + P Sbjct: 129 GMVKSLLYQILDGIHYLHAN--WVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSP 186 Query: 229 MGDLSYVSTRVMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGK 276 + L+ + V+ T+ Y APE + + H D+++ G + E+L+ + Sbjct: 187 LKPLADLDP-VVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSE 234 >3GUB-A nrPDB Length = 295 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 55/215 (25%), Positives = 95/215 (44%), Gaps = 32/215 (14%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT------EINYLG 126 +G G F V K + TGL A K + + + R ++ E++ L Sbjct: 19 LGSGQFAVVKKC---------REKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILK 69 Query: 127 QLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKP-LPWFLRVNVALDAA 185 ++ HPN++ L +L+ E + G L + L + + + FL+ Sbjct: 70 EIQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEATEFLK-----QIL 124 Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNA-----KLSDFGLARDGPMGDLSYVSTRVM 240 G+ +LHS +++ + D+K NI+L D N K+ DFGLA G+ + Sbjct: 125 NGVYYLHS--LQIAHFDLKPENIML-LDRNVPKPRIKIIDFGLAHKIDFGN---EFKNIF 178 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 GT + APE ++ L +D++S GV+ +LSG Sbjct: 179 GTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSG 213 >2VN9-A nrPDB Length = 301 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 88/213 (41%), Gaps = 32/213 (15%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG--HREWLTEINYLGQLSH 130 +G+G F V + K TG A K +N + H++ E L H Sbjct: 12 LGKGAFSVVRRC---------MKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKH 62 Query: 131 PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAF 190 PN+V+L E+ LV++ + G L + R Y + DA+ + Sbjct: 63 PNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEA-----------DASHCIQQ 111 Query: 191 L-----HSDPVKVIYRDIKASNILLDADYN---AKLSDFGLARDGPMGDLSYVSTRVMGT 242 + H +++RD+K N+LL + KL+DFGLA + ++ GT Sbjct: 112 ILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFG--FAGT 169 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 GY +PE + D+++ GV+L +L G Sbjct: 170 PGYLSPEVLRKDPYGKPVDMWACGVILYILLVG 202 >3GC0-A nrPDB Length = 329 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 100/219 (45%), Gaps = 34/219 (15%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL----NQEGFQGHREWLTEI 122 +R + +GEG +G V+K T +A+K++ +EG G + E+ Sbjct: 36 YRRITKLGEGTYGEVYKA---------IDTVTNETVAIKRIRLEHEEEGVPGTA--IREV 84 Query: 123 NYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRR-GAYFKPLPWFLRVNV 180 + L +L H N+++L + HRL L++E+ + L+ ++ + + + FL Sbjct: 85 SLLKELQHRNIIELKS-VIHHNHRLHLIFEYAE-NDLKKYMDKNPDVSMRVIKSFL---- 138 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILL---DADYNA--KLSDFGLARDGPMGDLSYV 235 G+ F HS + ++RD+K N+LL DA K+ DFGLAR G Sbjct: 139 -YQLINGVNFCHSR--RCLHRDLKPQNLLLSVSDASETPVLKIGDFGLAR--AFGIPIRQ 193 Query: 236 STRVMGTYGYAAPEY-MSSGHLNARSDVYSFGVLLLEIL 273 T + T Y PE + S H + D++S + E+L Sbjct: 194 FTHEIITLWYRPPEILLGSRHYSTSVDIWSIACIWAEML 232 >3LM0-A nrPDB Length = 327 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 52/207 (25%), Positives = 97/207 (46%), Gaps = 35/207 (16%) Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADY---NAKLSDFGLARD-GPMGDLSYVSTRVMG 241 +G+ +LH + +++ D+K NILL + Y + K+ DFG++R G +L +MG Sbjct: 142 EGVYYLHQN--NIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELR----EIMG 195 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK 301 T Y APE ++ + +D+++ G++ +L+ H P E D YL Sbjct: 196 TPEYLAPEILNYDPITTATDMWNIGIIAYMLLT------HTSPFVGE---DNQETYLNI- 245 Query: 302 RKVLLIVDNRLDTQYLPE---EAVRMASVAVQCLSFE-PKSRPTMDQVVRA--LQQLQ-D 354 ++++ Y E ++A+ +Q L + P+ RPT + + LQQ + Sbjct: 246 --------SQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFE 297 Query: 355 NLGKPSQTNPVKDTKKLGFKTGTTKSS 381 NL P +T+ T+ ++ K+S Sbjct: 298 NLFHPEETSSSSQTQDHSVRSSEDKTS 324 >5TE0-A nrPDB Length = 347 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 56/222 (25%), Positives = 97/222 (43%), Gaps = 34/222 (15%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL---NQEGFQGHREWLTEINYLG 126 D V+ EGGF VF + G+ A+K++ N+ Q + EI + Sbjct: 24 DEVLAEGGFAIVFL----------VRTSNGMKCALKRMFVNNEHDLQVCKR---EIQIMR 70 Query: 127 QLS-HPNLVKLIGYCLEDEHR------LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 LS H N+V I + + L++ +F + G + N + +R L++ Sbjct: 71 DLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQI- 129 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD---GPMGD-LSYV 235 D + +A LH +I+RD+K NILL + L DFG A + P + ++ V Sbjct: 130 -FCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAV 188 Query: 236 STRV--MGTYGYAAPEYM---SSGHLNARSDVYSFGVLLLEI 272 + T Y APE + S + ++D+++ G LL ++ Sbjct: 189 EDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKL 230 >3FXW-A nrPDB Length = 336 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 37/132 (28%), Positives = 60/132 (45%), Gaps = 11/132 (8%) Query: 147 LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKAS 206 L++ E M+ G L + + RG + + D + FLHS + +RD+K Sbjct: 102 LIIMECMEGGELFSRIQERGD--QAFTEREAAEIMRDIGTAIQFLHSH--NIAHRDVKPE 157 Query: 207 NILL---DADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVY 263 N+L + D KL+DFG A++ L T Y Y APE + + D++ Sbjct: 158 NLLYTSKEKDAVLKLTDFGFAKETTQNALQ---TPCYTPY-YVAPEVLGPEKYDKSCDMW 213 Query: 264 SFGVLLLEILSG 275 S GV++ +L G Sbjct: 214 SLGVIMYILLCG 225 >2I6L-A nrPDB Length = 320 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 71/304 (23%), Positives = 128/304 (42%), Gaps = 48/304 (15%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +G GG G VF ++ +A+KK+ Q + L EI + +L H N Sbjct: 19 LGCGGNGLVFSAVDNDCDKR---------VAIKKIVLTDPQSVKHALREIKIIRRLDHDN 69 Query: 133 LVKL--------------IGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 +VK+ +G E +V E+M+ L N + +G + Sbjct: 70 IVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET-DLAN-VLEQGPLLEEHARLFMY 127 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDA-DYNAKLSDFGLAR--DGPMGDLSYV 235 + +GL ++HS V++RD+K +N+ ++ D K+ DFGLAR D ++ Sbjct: 128 QL----LRGLKYIHS--ANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHL 181 Query: 236 STRVMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWA 294 S ++ T Y +P +S + D+++ G + E+L+GK ++ L+ + Sbjct: 182 SEGLV-TKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILES 240 Query: 295 RPYLTSK-RKVLLIV-----------DNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTM 342 P + + R+ LL V ++ TQ LP + Q L+F P R T Sbjct: 241 IPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTA 300 Query: 343 DQVV 346 ++ + Sbjct: 301 EEAL 304 >5TUR-A nrPDB Length = 404 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 76/302 (25%), Positives = 121/302 (40%), Gaps = 88/302 (29%) Query: 72 VIGEGGFGCVFKG---------------------W--LDESTLTPTKPGTGLVIAVKKLN 108 ++G GGFG V+ G W L T P + V+ +KK++ Sbjct: 134 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME-----VVLLKKVS 188 Query: 109 QEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAY 168 GF G I L P+ LI E L + ++G+L+ L R Sbjct: 189 S-GFSG------VIRLLDWFERPDSFVLILERPEPVQDLFDF-ITERGALQEELARS--- 237 Query: 169 FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFG---LA 224 +F +V L+A + H V++RDIK NIL+D + KL DFG L Sbjct: 238 -----FFWQV---LEAVR-----HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL 284 Query: 225 RDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKRALDHNR 283 +D V T GT Y+ PE++ + RS V+S G+LL +++ G +H+ Sbjct: 285 KDT-------VYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD- 336 Query: 284 PAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMD 343 E ++ + +V + Q+L +R CL+ P RPT + Sbjct: 337 ----EEII---------RGQVFFRQRVSSECQHL----IRW------CLALRPSDRPTFE 373 Query: 344 QV 345 ++ Sbjct: 374 EI 375 >3DLS-A nrPDB Length = 335 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 38/113 (33%), Positives = 55/113 (48%), Gaps = 11/113 (9%) Query: 198 VIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEY-MSSGHL 256 +I+RDIK NI++ D+ KL DFG A G L Y GT Y APE M + + Sbjct: 151 IIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYT---FCGTIEYCAPEVLMGNPYR 207 Query: 257 NARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWA--RPYLTSKRKVLLI 307 +++S GV L ++ + N + E V+ A PYL SK + L+ Sbjct: 208 GPELEMWSLGVTLYTLV-----FEENPFCELEETVEAAIHPPYLVSKELMSLV 255 >3ZUT-A nrPDB Length = 362 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 56/206 (27%), Positives = 86/206 (41%), Gaps = 22/206 (10%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IG G FG + L K LV AVK + + G + EI L HPN Sbjct: 27 IGSGNFGV--------ARLMRDKQSNELV-AVKYI-ERGEKIDENVKREIINHRSLRHPN 76 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 +V+ L H +V E+ G L + G + + F + G+++ H Sbjct: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQQL----ISGVSYCH 132 Query: 193 SDPVKVIYRDIKASNILLDAD--YNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEY 250 + ++V +RD+K N LLD K+ FG ++ L +GT Y APE Sbjct: 133 A--MQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSV---LHSQPKSTVGTPAYIAPEV 187 Query: 251 MSSGHLNAR-SDVYSFGVLLLEILSG 275 + + + +DV+S GV L +L G Sbjct: 188 LLKKEYDGKVADVWSCGVTLYVMLVG 213 >5VC6-A nrPDB Length = 289 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 46/155 (29%), Positives = 71/155 (45%), Gaps = 24/155 (15%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTE 121 T F IG G FG VFK K G + A+K+ + G + L E Sbjct: 10 TTEFHELEKIGSGEFGSVFKC---------VKRLDGCIYAIKRSKKPLAGSVDEQNALRE 60 Query: 122 I---NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHL---FRRGAYFKPLPWF 175 + LGQ SH +V+ ED+H L+ E+ GSL + + +R +YFK Sbjct: 61 VYAHAVLGQHSH--VVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAEL- 117 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILL 210 ++ L +GL ++HS + +++ DIK SNI + Sbjct: 118 --KDLLLQVGRGLRYIHS--MSLVHMDIKPSNIFI 148 >5X1R-A nrPDB Length = 302 Score = 48.1 bits (113), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 71/313 (22%), Positives = 128/313 (40%), Gaps = 51/313 (16%) Query: 55 FTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE---G 111 + FNE ++ IGEGGFG V++ + D + ++ K N + G Sbjct: 18 YRFNEFEI-------QEAIGEGGFGIVYRAY-DHQLERTIAIKEYMPTSLAKRNDDLSIG 69 Query: 112 FQGHR----------EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENH 161 +G R ++ E L + SHP L+ ++ + E+ + +F +L+N Sbjct: 70 LRGERFGKTFQAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNL 129 Query: 162 LFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDF 221 ++ W R+ L +A + +H + ++RDI NI + L DF Sbjct: 130 QAQQPEKIDEA-WIRRLLPPLFSA--INTIHQE--GYLHRDISLDNIQIQESQLPVLLDF 184 Query: 222 GLARDGPMGDLSYVSTRVMGTYGYAAPEYM---SSGHLNARSDVYSFGVLLLEILSGKRA 278 G AR +G+LS T ++ G+A E S G +D+Y+ G +L ++ G Sbjct: 185 GSARK-EIGNLS-DETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP 242 Query: 279 LDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKS 338 P ++ + LT +R Y PE + + L+ +P+ Sbjct: 243 -----PVSVVRSIEDSYQPLTERRPA----------GYSPE----LLRTVDRALALKPED 283 Query: 339 RP-TMDQVVRALQ 350 RP T+D++ L+ Sbjct: 284 RPQTIDEMAELLE 296 >4RC3-A nrPDB Length = 289 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 46/162 (28%), Positives = 75/162 (46%), Gaps = 36/162 (22%) Query: 189 AFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFG---LARDGPMGDLSYVSTRVMGTYG 244 A H V++RDIK NIL+D + KL DFG L +D V T GT Sbjct: 130 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-------VYTDFDGTRV 182 Query: 245 YAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRK 303 Y+ PE++ + RS V+S G+LL +++ G +H+ E ++ R + +++ Sbjct: 183 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-----EEII---RGQVFFRQR 234 Query: 304 VLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQV 345 V + Q+L +R CL+ P RPT +++ Sbjct: 235 V------SSECQHL----IRW------CLALRPSDRPTFEEI 260 >3BGP-A nrPDB Length = 333 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 71/290 (24%), Positives = 128/290 (44%), Gaps = 64/290 (22%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT------EINYL 125 ++G GGFG V+ G + L +A+K + ++ E E+ L Sbjct: 63 LLGSGGFGSVYSG---------IRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 113 Query: 126 GQLSH--PNLVKLIGYCLEDEHRLLVYEFMQK-GSLENHLFRRGAYFKPLP--WFLRVNV 180 ++S +++L+ + + +L+ E + L + + RGA + L +F +V Sbjct: 114 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV-- 171 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFG---LARDGPMGDLSYVS 236 L+A + H V++RDIK NIL+D + KL DFG L +D V Sbjct: 172 -LEAVR-----HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-------TVY 218 Query: 237 TRVMGTYGYAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 T GT Y+ PE++ + RS V+S G+LL +++ G +H+ E ++ R Sbjct: 219 TDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-----EEII---R 270 Query: 296 PYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQV 345 + +++V + Q+L +R CL+ P RPT +++ Sbjct: 271 GQVFFRQRV------SSECQHL----IRW------CLALRPSDRPTFEEI 304 >3HMP-A nrPDB Length = 342 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 63/288 (21%), Positives = 124/288 (43%), Gaps = 46/288 (15%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IG GG VF+ ++ + K + +++ + + +R + +N L Q S Sbjct: 64 IGSGGSSKVFQVLNEKKQIYAIK-----YVNLEEADNQTLDSYRNEIAYLNKLQQHSD-K 117 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLE-NHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 +++L Y + D++ +Y M+ G+++ N ++ P + R + + + + + Sbjct: 118 IIRLYDYEITDQY---IYMVMECGNIDLNSWLKKKKSIDP---WERKSYWKNMLEAVHTI 171 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEY- 250 H +++ D+K +N L+ D KL DFG+A S V +GT Y PE Sbjct: 172 HQH--GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 228 Query: 251 --MSSGHLNA--------RSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 MSS N +SDV+S G +L + GK + + Sbjct: 229 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---------------QQIINQ 273 Query: 301 KRKVLLIVDNRLDTQY--LPEEAVRMASVAVQCLSFEPKSRPTMDQVV 346 K+ I+D + ++ +PE+ ++ V CL +PK R ++ +++ Sbjct: 274 ISKLHAIIDPNHEIEFPDIPEKDLQ--DVLKCCLKRDPKQRISIPELL 319 >5AP3-A nrPDB Length = 313 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 65/308 (21%), Positives = 131/308 (42%), Gaps = 46/308 (14%) Query: 53 KSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF 112 ++ F + + R + IG GG VF+ ++ + K + +++ + + Sbjct: 16 ENLYFQSMSVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIK-----YVNLEEADNQTL 70 Query: 113 QGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLE-NHLFRRGAYFKP 171 +R + +N L Q S +++L Y + D++ +Y M+ G+++ N ++ P Sbjct: 71 DSYRNEIAYLNKLQQHSD-KIIRLYDYEITDQY---IYMVMECGNIDLNGWLKKKKSIDP 126 Query: 172 LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGD 231 + R + + + + +H +++ D+K +N L+ D KL DFG+A Sbjct: 127 ---WERKSYWKNMLEAVHTIHQH--GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDT 180 Query: 232 LSYVSTRVMGTYGYAAPEY---MSSGHLNA--------RSDVYSFGVLLLEILSGKRALD 280 S V +GT Y PE MSS N +SDV+S G +L + GK Sbjct: 181 TSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF- 239 Query: 281 HNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQY--LPEEAVRMASVAVQCLSFEPKS 338 + + K+ I+D + ++ +PE+ ++ V CL +PK Sbjct: 240 --------------QQIINQISKLHAIIDPNHEIEFPDIPEKDLQ--DVLKCCLKRDPKQ 283 Query: 339 RPTMDQVV 346 R ++ +++ Sbjct: 284 RISIPELL 291 >2A27-A nrPDB Length = 321 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 95/213 (44%), Gaps = 28/213 (13%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT------EINYLG 126 +G G F V K + TGL A K + + + R ++ E++ L Sbjct: 20 LGSGQFAIVKKC---------REKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILR 70 Query: 127 QLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAK 186 Q+ H N++ L +L+ E + G L + L ++ + + + LD Sbjct: 71 QVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSF-IKQILD--- 126 Query: 187 GLAFLHSDPVKVIYRDIKASNI-LLDADY---NAKLSDFGLARDGPMGDLSYVSTRVMGT 242 G+ +LH+ K+ + D+K NI LLD + + KL DFGLA + G + GT Sbjct: 127 GVNYLHTK--KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDG---VEFKNIFGT 181 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 + APE ++ L +D++S GV+ +LSG Sbjct: 182 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSG 214 >1ZWS-A nrPDB Length = 288 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 56/213 (26%), Positives = 95/213 (44%), Gaps = 28/213 (13%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT------EINYLG 126 +G G F V K + TGL A K + + + R ++ E++ L Sbjct: 20 LGSGQFAIVKKC---------REKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILR 70 Query: 127 QLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAK 186 Q+ H N++ L +L+ E + G L + L ++ + + + LD Sbjct: 71 QVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSF-IKQILD--- 126 Query: 187 GLAFLHSDPVKVIYRDIKASNI-LLDADY---NAKLSDFGLARDGPMGDLSYVSTRVMGT 242 G+ +LH+ K+ + D+K NI LLD + + KL DFGLA + G + GT Sbjct: 127 GVNYLHTK--KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDG---VEFKNIFGT 181 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 + APE ++ L +D++S GV+ +LSG Sbjct: 182 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSG 214 >3N9X-A nrPDB Length = 432 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 58/240 (24%), Positives = 98/240 (40%), Gaps = 50/240 (20%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTEIN 123 N+ +IG G +G V+ + T +A+KK+N+ E + L EI Sbjct: 27 NYIIKHLIGRGSYGYVYLAY---------DKNTEKNVAIKKVNRMFEDLIDCKRILREIT 77 Query: 124 YLGQLSHPNLVKLIGYCLEDE-----HRLLVYEFMQ---KGSLENHLFRRGAYFKPLPWF 175 L +L +++L + D+ +V E K + +F + K + + Sbjct: 78 ILNRLKSDYIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFKTPIFLTEEHIKTILYN 137 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD--------- 226 L + G F+H +I+RD+K +N LL+ D + K+ DFGLAR Sbjct: 138 LLL--------GENFIHES--GIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNI 187 Query: 227 ----------GPMG-DLSYVSTRVMGTYGYAAPEYMSSGHLNARS-DVYSFGVLLLEILS 274 GP +L T + T Y APE + +S D++S G + E+L+ Sbjct: 188 VNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLN 247 >2WTK-B nrPDB Length = 373 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 71/279 (25%), Positives = 117/279 (41%), Gaps = 50/279 (17%) Query: 71 SVIGEGG----FGCVFKGWLDEST--LTPTKPGTGLVIAVKKLNQEGFQGHREWLT---- 120 S + EGG + KG+ D T L KP TG + V+++N E E +T Sbjct: 3 SFLPEGGCYELLTVIGKGFEDLMTVNLARYKP-TGEYVTVRRINLEACSN--EMVTFLQG 59 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHL---FRRGAYFKPLPWFLR 177 E++ +HPN+V + D +V FM GS ++ + F G + + L+ Sbjct: 60 ELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQ 119 Query: 178 -VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLS----DFGLARDGP---- 228 V ALD + ++H R +KAS+IL+ D LS + + G Sbjct: 120 GVLKALDYIHHMGYVH--------RSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRV 171 Query: 229 MGDLSYVSTRVMGTYGYAAPEYMSSG--HLNARSDVYSFGVLLLEILSGKRALDHNRPAK 286 + D S +V+ + +PE + +A+SD+YS G+ E+ +G + PA Sbjct: 172 VHDFPKYSVKVLP---WLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFK-DMPAT 227 Query: 287 EENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMA 325 + L K+ V LDT +P E + M+ Sbjct: 228 QMLL-----------EKLNGTVPCLLDTSTIPAEELTMS 255 >2Y4I-B nrPDB Length = 319 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 67/324 (20%), Positives = 130/324 (40%), Gaps = 70/324 (21%) Query: 54 SFTFNELKLATRNFRPDSVIGEGGFGCVFKG-WLDESTLTPTKPGTGLVIAVKKLNQEGF 112 S E + +IG+G FG V+ G W E + +I +++ N++ Sbjct: 22 SIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIR--------LIDIERDNEDQL 73 Query: 113 QGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPL 172 + + E+ Q H N+V +G C+ H L + + KG + R Sbjct: 74 KAFKR---EVMAYRQTRHENVVLFMGACMSPPH-LAIITSLCKGRTLYSVVRDAKI---- 125 Query: 173 PWFLRVN----VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGL----- 223 L VN +A + KG+ +LH+ ++++D+K+ N+ D + ++DFGL Sbjct: 126 --VLDVNKTRQIAQEIVKGMGYLHAK--GILHKDLKSKNVFYD-NGKVVITDFGLFSISG 180 Query: 224 -ARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGH---------LNARSDVYSFGVLLLEIL 273 + G D + G + APE + + SDV++ G + E+ Sbjct: 181 VLQAGRREDKLRIQN---GWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYEL- 236 Query: 274 SGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAV-----RMASVA 328 H R +W P+ T + ++ ++ T P + ++ + Sbjct: 237 -------HAR--------EW--PFKTQPAEAIIW---QMGTGMKPNLSQIGMGKEISDIL 276 Query: 329 VQCLSFEPKSRPTMDQVVRALQQL 352 + C +FE + RPT +++ L++L Sbjct: 277 LFCWAFEQEERPTFTKLMDMLEKL 300 >5VD3-A nrPDB Length = 311 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 76/295 (25%), Positives = 115/295 (38%), Gaps = 61/295 (20%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 ++F+ S +G G +G VFK E G + AVK+ + F+G ++ ++ Sbjct: 57 QSFQRLSRLGHGSYGEVFKVRSKED---------GRLYAVKR-SMSPFRGPKDRARKLAE 106 Query: 125 LGQL----SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 +G HP V+L E+ L + + SL+ H GA LP Sbjct: 107 VGSHEKVGQHPCCVRLE-QAWEEGGILYLQTELCGPSLQQHCEAWGAS---LPEAQVWGY 162 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 D LA LHS +++ D+K +NI L KL DFGL L + T Sbjct: 163 LRDTLLALAHLHSQ--GLVHLDVKPANIFLGPRGRCKLGDFGL--------LVELGTAGA 212 Query: 241 GTYGYAAPEYMS----SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 G P YM+ G +DV+S G+ +LE+ A + P E W Sbjct: 213 GEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEV-----ACNMELPHGGEG---W--- 261 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEE-----AVRMASVAVQCLSFEPKSRPTMDQVV 346 +L YLP E + + SV V L +PK R T + ++ Sbjct: 262 -------------QQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALL 303 >3RP9-A nrPDB Length = 458 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 58/236 (24%), Positives = 101/236 (42%), Gaps = 49/236 (20%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTEINYLGQLS 129 +IG G +G V + + V+A+KK+ + E + L EI L +L+ Sbjct: 60 LIGTGSYGHVCEAY---------DKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLN 110 Query: 130 HPNLVKLIGYCL----EDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL-DA 184 H ++VK++ + E L V + + LFR Y L + L + Sbjct: 111 HDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKK-LFRTPVYLTEL----HIKTLLYNL 165 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR--DGP-------------- 228 G+ ++HS +++RD+K +N L++ D + K+ DFGLAR D P Sbjct: 166 LVGVKYVHS--AGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPRED 223 Query: 229 -MGDLSYVSTRVMG--------TYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILS 274 M +++ T+ + T Y APE + + DV+S G + E+L+ Sbjct: 224 DMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLN 279 >2ZMD-A nrPDB Length = 390 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 62/288 (21%), Positives = 123/288 (42%), Gaps = 46/288 (15%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IG GG VF+ ++ + K + +++ + + +R + +N L Q S Sbjct: 64 IGSGGSSKVFQVLNEKKQIYAIK-----YVNLEEADNQTLDSYRNEIAYLNKLQQHSD-K 117 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLE-NHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 +++L Y + D++ +Y M+ G+++ N ++ P + R + + + + + Sbjct: 118 IIRLYDYEITDQY---IYMVMECGNIDLNSWLKKKKSIDP---WERKSYWKNMLEAVHTI 171 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEY- 250 H +++ D+K +N L+ D KL DFG+A S V +G Y PE Sbjct: 172 HQH--GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAI 228 Query: 251 --MSSGHLNA--------RSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 MSS N +SDV+S G +L + GK + + Sbjct: 229 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF---------------QQIINQ 273 Query: 301 KRKVLLIVDNRLDTQY--LPEEAVRMASVAVQCLSFEPKSRPTMDQVV 346 K+ I+D + ++ +PE+ ++ V CL +PK R ++ +++ Sbjct: 274 ISKLHAIIDPNHEIEFPDIPEKDLQ--DVLKCCLKRDPKQRISIPELL 319 >5YKS-A nrPDB Length = 377 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 43/185 (23%), Positives = 83/185 (44%), Gaps = 16/185 (8%) Query: 98 TGLVIAVKKLNQEGFQ----GHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFM 153 TG +AVK +++ GH E+ + + HPN+V+L L+ E Sbjct: 59 TGEKVAVKVIDKTKLDTLATGH--LFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELG 116 Query: 154 QKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNIL-LDA 212 G + +++ + + + L L +++ H + V++RD+K N++ + Sbjct: 117 DGGDMFDYIMK---HEEGLNEDLAKKYFAQIVHAISYCHK--LHVVHRDLKPENVVFFEK 171 Query: 213 DYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARS-DVYSFGVLLLE 271 KL+DFG + G S G+ Y+APE + +A + D++S GV+L Sbjct: 172 QGLVKLTDFGFSNKFQPGKKLTTSC---GSLAYSAPEILLGDEYDAPAVDIWSLGVILFM 228 Query: 272 ILSGK 276 ++ G+ Sbjct: 229 LVCGQ 233 >2VD5-A nrPDB Length = 412 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 64/255 (25%), Positives = 100/255 (39%), Gaps = 75/255 (29%) Query: 57 FNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF---- 112 E++L +F VIG G F E + K TG V A+K +N+ Sbjct: 53 LKEVRLQRDDFEILKVIGRGAFS--------EVAVVKMKQ-TGQVYAMKIMNKWDMLKRG 103 Query: 113 -------------QGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSL 158 G R W+T++++ +DE+ L LV E+ G L Sbjct: 104 EVSCFREERDVLVNGDRRWITQLHF---------------AFQDENYLYLVMEYYVGGDL 148 Query: 159 ENHLFRRGAYFKPLP------WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDA 212 L + G + +P + + +A+D+ L ++H RDIK NILLD Sbjct: 149 LTLLSKFG---ERIPAEMARFYLAEIVMAIDSVHRLGYVH--------RDIKPDNILLDR 197 Query: 213 DYNAKLSDFG----LARDGPMGDLSYVSTRVMGTYGYAAPEYMSS-------GHLNARSD 261 + +L+DFG L DG + L V GT Y +PE + + G D Sbjct: 198 CGHIRLADFGSCLKLRADGTVRSLVAV-----GTPDYLSPEILQAVGGGPGTGSYGPECD 252 Query: 262 VYSFGVLLLEILSGK 276 ++ GV E+ G+ Sbjct: 253 WWALGVFAYEMFYGQ 267 >4O2Z-A nrPDB Length = 377 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 33/108 (30%), Positives = 55/108 (50%), Gaps = 17/108 (15%) Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR--DGPMGDLS-YVSTRVMGT 242 +GL +LHS V +RD+K +N++ + K+ DFGL+R D P +L+ YV TR Sbjct: 161 RGLKYLHS--ANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITR---- 214 Query: 243 YGYAAPE-YMSSGHLNARSDVYSFGVLLLE------ILSGKRALDHNR 283 Y PE + + + + D++S G + E + G+ +D R Sbjct: 215 -WYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLR 261 >6O6Q-A nrPDB Length = 335 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 59/271 (21%), Positives = 119/271 (43%), Gaps = 38/271 (14%) Query: 29 SRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLA---TRNFRPDSVIGEGGFGCVFKGW 85 S +TV + + ++LS+ P + +++L + N+ +G G + VF G Sbjct: 2 SSHRHNTVQSVSRVYADVLSTKPQSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLG- 60 Query: 86 LDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSH-PNLVKLIGYCLEDE 144 + K ++ +K + ++ + EI+ L L PN++ ++ E + Sbjct: 61 -----IDLEKREKVVIKVLKPVKRKKIK------REISILKNLVDGPNIIAMLDVVREPQ 109 Query: 145 HRL--LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL---DAAKGLAFLHSDPVKVI 199 + L++E + N++ R Y P F ++ + K L + HS + ++ Sbjct: 110 SKTPGLIFEHI------NNIDFRSLY----PTFTDYDIRFYMYELLKALDYSHS--MGIM 157 Query: 200 YRDIKASNILLDADYN-AKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNA 258 +RD+K N+++D D +L D+GLA G + + RV Y + PE + L Sbjct: 158 HRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPG--TEYNVRVASRY-FKGPELLVDYRLYD 214 Query: 259 RS-DVYSFGVLLLEILSGKRALDHNRPAKEE 288 S D++SFG +L ++ K H + ++ Sbjct: 215 YSLDMWSFGCMLASMVFMKEPFFHGKSNTDQ 245 >4LQP-A nrPDB Length = 508 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 49/165 (29%), Positives = 71/165 (43%), Gaps = 24/165 (14%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL-NQEGFQGHR--EWLTEI 122 +F VIG+G FG V K TG + A+K L E ++ + E Sbjct: 103 DFHTVKVIGKGAFGEV---------RLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAER 153 Query: 123 NYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN-- 179 + L P +V L Y +D L L+ EF+ G L L R + + + F Sbjct: 154 DVLAGSDSPWVVSLY-YSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECI 212 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLA 224 +A++ L F+H R IK NIL+D + KLSDFGL+ Sbjct: 213 LAIETIHKLGFIH--------RAIKPDNILIDIRGHIKLSDFGLS 249 >5Y86-A nrPDB Length = 588 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 92/213 (43%), Gaps = 28/213 (13%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 +IG+G FG V + + D +A+K + E + HR+ EI L L Sbjct: 214 IIGKGSFGQVARVY-DHKLRQ--------YVALKMVRNEK-RFHRQAAEEIRILEHLKKQ 263 Query: 132 ------NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 N++ ++ H + +E + S++ + + F+ L A Sbjct: 264 DKTGSMNVIHMLESFTFRNHVCMAFELL---SIDLYELIKKNKFQGFSVQLVRKFAQSIL 320 Query: 186 KGLAFLHSDPVKVIYRDIKASNILLD--ADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 + L LH + K+I+ D+K NILL + K+ DFG + +Y+ +R Sbjct: 321 QSLDALHKN--KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRF---- 374 Query: 244 GYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 Y APE + + D++SFG +L E+L+G+ Sbjct: 375 -YRAPEIILGSRYSTPIDIWSFGCILAELLTGQ 406 >3NIE-A nrPDB Length = 429 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 61/248 (24%), Positives = 101/248 (40%), Gaps = 55/248 (22%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTEIN 123 N+ +IG G +G V+ + +A+KK+N+ E + L EI Sbjct: 29 NYEIKHLIGRGSYGYVYLAY---------DKNANKNVAIKKVNRMFEDLIDCKRILREIT 79 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQK-GSLENHLFRRGAYFKPL---PWFLRVN 179 L +L +++L H L++ E + K L L + K L P FL Sbjct: 80 ILNRLKSDYIIRL--------HDLIIPEDLLKFDELYIVLEIADSDLKKLFKTPIFLTEQ 131 Query: 180 ----VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD--------- 226 + + G F+H +I+RD+K +N LL+ D + K+ DFGLAR Sbjct: 132 HVKTILYNLLLGEKFIHES--GIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHI 189 Query: 227 -------------GPMG-DLSYVSTRVMGTYGYAAPE--YMSSGHLNARSDVYSFGVLLL 270 GP +L T + T Y APE + + N+ D++S G + Sbjct: 190 VNDLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNS-IDIWSTGCIFA 248 Query: 271 EILSGKRA 278 E+L+ ++ Sbjct: 249 ELLNMMKS 256 >2WO6-A nrPDB Length = 382 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 92/220 (41%), Gaps = 30/220 (13%) Query: 67 FRPDSVIGEGGFGCVFKGW-LDESTLTPTKPGTGLVIAVKK--LNQEGFQGHREWL---- 119 + DS+IG+G FG V K + E K +I KK LNQ + L Sbjct: 56 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIK-----IIKNKKAFLNQAQIEVRLLELMNKH 110 Query: 120 -TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 TE+ Y +V L + + H LV+E + S + R F+ + L Sbjct: 111 DTEMKYY-------IVHLKRHFMFRNHLCLVFEML---SYNLYDLLRNTNFRGVSLNLTR 160 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA--KLSDFGLARDGPMGDLSYVS 236 A L FL + + +I+ D+K NILL + K+ DFG + Y+ Sbjct: 161 KFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQ 220 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 +R Y +PE + + D++S G +L+E+ +G+ Sbjct: 221 SRF-----YRSPEVLLGMPYDLAIDMWSLGCILVEMHTGE 255 >3PG1-A nrPDB Length = 362 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 74/303 (24%), Positives = 119/303 (39%), Gaps = 44/303 (14%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN--QEGFQGHREWLTEINYLGQLSH 130 I G +G V G E K V + +N + F R L EI L H Sbjct: 30 ISSGSYGAVCAGVDSEGIPVAIKRVFNTVSDGRTVNILSDSFLCKR-VLREIRLLNHFHH 88 Query: 131 PNLVKLIGYCLEDE----HRLLVYEFMQKGSLENHLFRRGAYFKP--LPWFLRVNVALDA 184 PN++ L + E H+L + + + L + + P + +F+ ++ L Sbjct: 89 PNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISPQHIQYFM-YHILL-- 145 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD--GPMGDLSYVSTRVMGT 242 GL LH V++RD+ NILL + + + DF LAR+ YV+ R Sbjct: 146 --GLHVLHE--AGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHR---- 197 Query: 243 YGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGK-------------RALDHNRPAKEE 288 Y APE M D++S G ++ E+ + K + ++ K E Sbjct: 198 -WYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIE 256 Query: 289 NLVDW----ARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQ 344 ++V + AR YL R L V R T +P + + L F P+ R + +Q Sbjct: 257 DVVMFSSPSARDYL---RNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQ 313 Query: 345 VVR 347 +R Sbjct: 314 ALR 316 >2OZA-A nrPDB Length = 356 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 28/94 (29%), Positives = 50/94 (53%), Gaps = 8/94 (8%) Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADY-NA--KLSDFGLARDGPMGDLSYVSTRVMG 241 + + +LHS + + +RD+K N+L + NA KL+DFG A++ + ++T Sbjct: 127 GEAIQYLHS--INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN--SLTTPCYT 182 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 Y Y APE + + D++S GV++ +L G Sbjct: 183 PY-YVAPEVLGPEKYDKSCDMWSLGVIMYILLCG 215 >1NY3-A nrPDB Length = 400 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 28/94 (29%), Positives = 50/94 (53%), Gaps = 8/94 (8%) Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADY-NA--KLSDFGLARDGPMGDLSYVSTRVMG 241 + + +LHS + + +RD+K N+L + NA KL+DFG A++ + ++T Sbjct: 171 GEAIQYLHS--INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN--SLTTPCYT 226 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 Y Y APE + + D++S GV++ +L G Sbjct: 227 PY-YVAPEVLGPEKYDKSCDMWSLGVIMYILLCG 259 >3KA0-A nrPDB Length = 320 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 30/95 (31%), Positives = 50/95 (52%), Gaps = 10/95 (10%) Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADY-NA--KLSDFGLARDGPMGDLSYVS-TRVM 240 + + +LHS + + +RD+K N+L + NA KL+DFG A++ S+ S T Sbjct: 125 GEAIQYLHS--INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKET----TSHNSLTEPC 178 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 T Y APE + + D++S GV++ +L G Sbjct: 179 YTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCG 213 >5GZA-A nrPDB Length = 290 Score = 41.2 bits (95), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 65/272 (23%), Positives = 110/272 (40%), Gaps = 43/272 (15%) Query: 103 AVKKLNQEGFQGHR-------------EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLV 149 AVKK+ +QG + ++L ++ L L ++V L+G C ED + V Sbjct: 37 AVKKVYLSEWQGQKVALSVLSSDQYADDFLHGLSMLRALQSSHVVTLVGVCEEDA--VFV 94 Query: 150 YEFMQKGS---LENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKAS 206 E+ GS L+ L + ++ W R+ +A+D LA+LHS P + R + S Sbjct: 95 TEYHPLGSVLTLDTTLAQERYRWRN-SWHTRLQLAIDYVAFLAYLHSSPAGI--RVMCDS 151 Query: 207 NILLDADYNAKLSDFGLARDGPM--GDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYS 264 N D + LS F LA D + DL + G G + +G A ++ Sbjct: 152 N-----DLHKTLSQFLLASDMRLLANDLDALPEVEKGGLGVKCGHHELTGDFVAPEQLWP 206 Query: 265 FGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRM 324 +G E S D P +E W P +T ++ + L + ++ Sbjct: 207 YG----EDFSFS---DEAMPGYDEKTDIWKIPDVTR-----FLLGDVLGGDVIHFHLFQI 254 Query: 325 ASVAVQCLSFEPKSRPTMDQVVRALQQLQDNL 356 S +C E RPT +V+ + + D++ Sbjct: 255 YS---ECKRKEAHMRPTAREVLSVYRSVYDSM 283 >6FYV-A nrPDB Length = 337 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 60/229 (26%), Positives = 96/229 (41%), Gaps = 46/229 (20%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL-TEINYLGQL--S 129 +GEG FG V + +D G+ +AVK + G +RE +EI L L + Sbjct: 22 LGEGAFGKVVEC-IDHGM-------DGMHVAVKIVKNVG--RYREAARSEIQVLEHLNST 71 Query: 130 HPN----LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 PN V+++ + H +V+E + L + F + F P +A Sbjct: 72 DPNSVFRCVQMLEWFDHHGHVCIVFELL---GLSTYDFIKENSFLPFQIDHIRQMAYQIC 128 Query: 186 KGLAFLHSDPVKVIYRDIKASNIL-LDADY------------------NAKLSDFGLARD 226 + + FLH + K+ + D+K NIL + +DY + K+ DFG A Sbjct: 129 QSINFLHHN--KLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY 186 Query: 227 GPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 + VSTR Y APE + + + DV+S G +L+E G Sbjct: 187 DDEHHSTLVSTR-----HYRAPEVILALGWSQPCDVWSIGCILIEYYLG 230 >5ZTN-A nrPDB Length = 429 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 53/212 (25%), Positives = 88/212 (41%), Gaps = 28/212 (13%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 VIG+G FG V K + D +A+K + E + HR+ EI L L Sbjct: 104 VIGKGSFGQVVKAY-DHKVHQH--------VALKMVRNEK-RFHRQAAEEIRILEHLRKQ 153 Query: 132 ------NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 N++ ++ H + +E + E L ++ F+ L A Sbjct: 154 DKDNTMNVIHMLENFTFRNHICMTFELLSMNLYE--LIKKNK-FQGFSLPLVRKFAHSIL 210 Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNA--KLSDFGLARDGPMGDLSYVSTRVMGTY 243 + L LH + ++I+ D+K NILL + K+ DFG + +Y+ +R Sbjct: 211 QCLDALHKN--RIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRF---- 264 Query: 244 GYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 Y APE + D++S G +L E+L+G Sbjct: 265 -YRAPEVILGARYGMPIDMWSLGCILAELLTG 295 >3EB0-A nrPDB Length = 383 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 57/258 (22%), Positives = 107/258 (41%), Gaps = 61/258 (23%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL 119 L+ +++ + +G G FG V + + ES G A+KK+ Q+ +RE Sbjct: 2 LETSSKKYSLGKTLGTGSFGIVCEVFDIES---------GKRFALKKVLQDPRYKNRE-- 50 Query: 120 TEINYLGQLSHPNLVKLIGYC--------------------------LEDEHRLLVYEFM 153 ++ + L H N++KL+ Y + + H+ ++ Sbjct: 51 --LDIMKVLDHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPS 108 Query: 154 QKGSLENHL-FRRGAYFKPLPWFLRVNVALDAA----------KGLAFLHSDPVKVIYRD 202 Q L + + K L F+R ++ + + F+HS + + +RD Sbjct: 109 QNKYLNVIMEYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHS--LGICHRD 166 Query: 203 IKASNILLDA-DYNAKLSDFGLARDGPMGD--LSYVSTRVMGTYGYAAPEYM-SSGHLNA 258 IK N+L+++ D KL DFG A+ + ++Y+ +R Y APE M + Sbjct: 167 IKPQNLLVNSKDNTLKLCDFGSAKKLIPSEPSVAYICSRF-----YRAPELMLGATEYTP 221 Query: 259 RSDVYSFGVLLLEILSGK 276 D++S G + E++ GK Sbjct: 222 SIDLWSIGCVFGELILGK 239 >5X8I-B nrPDB Length = 346 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 57/228 (25%), Positives = 92/228 (40%), Gaps = 44/228 (19%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQL--SH 130 +GEG FG V + + G + + + K + R +EI L L + Sbjct: 21 LGEGAFGKVVE------CIDHKAGGRHVAVKIVKNVDRYCEAAR---SEIQVLEHLNTTD 71 Query: 131 PN----LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAK 186 PN V+++ + H +V+E + L + F + F P +A K Sbjct: 72 PNSTFRCVQMLEWFEHHGHICIVFELL---GLSTYDFIKENGFLPFRLDHIRKMAYQICK 128 Query: 187 GLAFLHSDPVKVIYRDIKASNIL-LDADY------------------NAKLSDFGLARDG 227 + FLHS+ K+ + D+K NIL + +DY + K+ DFG A Sbjct: 129 SVNFLHSN--KLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYD 186 Query: 228 PMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 + VSTR Y APE + + + DV+S G +L+E G Sbjct: 187 DEHHSTLVSTR-----HYRAPEVILALGWSQPCDVWSIGCILIEYYLG 229 >5CLR-A nrPDB Length = 451 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 27/70 (38%), Positives = 35/70 (50%), Gaps = 13/70 (18%) Query: 198 VIYRDIKASNILLDADYNAKLSDFG-LARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHL 256 +I+RD+K NI+LDAD L DFG + D S+ GT Y APE L Sbjct: 197 LIHRDLKPGNIMLDADMQCHLVDFGSSSSDKEPKPASW------GTASYLAPE------L 244 Query: 257 NARSDVYSFG 266 NA+ D +F Sbjct: 245 NAQEDFIAFS 254 >5M07-A nrPDB Length = 276 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 41/196 (20%), Positives = 79/196 (40%), Gaps = 27/196 (13%) Query: 116 REWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 R + E +L HP+++++ D + +++ H+ R P+ Sbjct: 75 RRFQRETEVAARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEV 134 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDA----DYNAKLSDFGLARDGPMGD 231 L + A+ A L + H +++RD+ +N++L + D L+DFG+A Sbjct: 135 LAIVTAV--AGALDYAHQR--GLLHRDVNPANVVLTSQSAGDQRILLADFGIA------- 183 Query: 232 LSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALD--HNRPAKEEN 289 Y APE + ++ R+D Y+ + + + +G +D H P + Sbjct: 184 ---------SQPSYPAPELSAGADVDGRADQYALALTAIHLFAGAPPVDRSHTGPLQPPK 234 Query: 290 LVDWARPYLTSKRKVL 305 L + RP L VL Sbjct: 235 LSAF-RPDLARLDGVL 249 >1TKI-A nrPDB Length = 321 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 47/185 (25%), Positives = 81/185 (43%), Gaps = 42/185 (22%) Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA--KLSDFGLARDGPMGDLSYV 235 V+ + L FLHS + + DI+ NI+ ++ K+ +FG AR GD Sbjct: 105 VSYVHQVCEALQFLHSHNIG--HFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGD---- 158 Query: 236 STRVMGTY-GYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWA 294 + R++ T Y APE ++ +D++S G L+ +LSG Sbjct: 159 NFRLLFTAPEYYAPEVHQHDVVSTATDMWSLGTLVYVLLSG------------------I 200 Query: 295 RPYLTSKRKVLLIVDNRLDTQY-LPEEAVRMASVAVQCLSF-------EPKSRPTMDQVV 346 P+L + I++N ++ +Y EEA + ++++ + F E KSR T + Sbjct: 201 NPFLAETNQ--QIIENIMNAEYTFDEEAFK--EISIEAMDFVDRLLVKERKSRMTASE-- 254 Query: 347 RALQQ 351 ALQ Sbjct: 255 -ALQH 258 >5UNP-A nrPDB Length = 369 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 50/230 (21%), Positives = 95/230 (41%), Gaps = 44/230 (19%) Query: 71 SVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSH 130 S +GEG FG V + + + G + + + K ++ + R EIN L +++ Sbjct: 40 STLGEGTFGRVVQ------CVDHRRGGARVALKIIKNVEKYKEAAR---LEINVLEKINE 90 Query: 131 PN------LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 + V++ + H + +E + + + F + + P P ++A Sbjct: 91 KDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFD---FLKDNNYLPYPIHQVRHMAFQL 147 Query: 185 AKGLAFLHSDPVKVIYRDIKASNIL-LDADYN------------------AKLSDFGLAR 225 + + FLH + K+ + D+K NIL +++DY ++ DFG A Sbjct: 148 CQAVKFLHDN--KLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA- 204 Query: 226 DGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 D + ST ++ T Y APE + + DV+S G ++ E G Sbjct: 205 ---TFDHEHHST-IVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVG 250 >5VDK-A nrPDB Length = 297 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 44/167 (26%), Positives = 74/167 (44%), Gaps = 31/167 (18%) Query: 57 FNELKLATR---NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKK------- 106 F +A+R F IG G FG V+K K G V A+K+ Sbjct: 4 FGSTNMASRYEKEFLEVEKIGVGEFGTVYKC---------IKRLDGCVYAIKRSMKTFTE 54 Query: 107 LNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHL---F 163 L+ E H + + LG HP++V+ ED+H ++ E+ GSL+ + Sbjct: 55 LSNENSALHEVYAHAV--LGH--HPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENT 110 Query: 164 RRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILL 210 + G +F+ P ++ L + GL ++H+ +++ DIK SNI + Sbjct: 111 KSGNHFEE-PKL--KDILLQISLGLNYIHNS--SMVHLDIKPSNIFI 152 >2WTK-C nrPDB Length = 305 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 56/212 (26%), Positives = 92/212 (43%), Gaps = 22/212 (10%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 ++GEG +G V K LD TL + I KK + G EI L +L H Sbjct: 12 LLGEGSYGKV-KEVLDSETLC----RRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHK 66 Query: 132 NLVKLIG--YCLEDEHRLLVYEFMQKGS---LENHLFRRGAYFKPLPWFLRVNVALDAAK 186 N+++L+ Y E + +V E+ G L++ +R + +F ++ Sbjct: 67 NVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQL------ID 120 Query: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD-GPMGDLSYVSTRVMGTYGY 245 GL +LHS ++++DIK N+LL K+S G+A P T G+ + Sbjct: 121 GLEYLHSQ--GIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTS-QGSPAF 177 Query: 246 AAPEYMSSGHLNA--RSDVYSFGVLLLEILSG 275 PE + + + D++S GV L I +G Sbjct: 178 QPPEIANGLDTFSGFKVDIWSAGVTLYNITTG 209 >4IAN-A nrPDB Length = 358 Score = 35.8 bits (81), Expect = 0.034, Method: Compositional matrix adjust. Identities = 26/81 (32%), Positives = 41/81 (50%), Gaps = 7/81 (8%) Query: 198 VIYRDIKASNILLDADYNA-KLSDFGLARDGPMGDLS-YVSTRVMGTYGYAAPEYMSSGH 255 +++ DIK NIL++ KL DFG A D++ Y+ +R Y APE + Sbjct: 156 ILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRF-----YRAPEIIIGKS 210 Query: 256 LNARSDVYSFGVLLLEILSGK 276 + D++S G L E+ +GK Sbjct: 211 YDYGIDMWSVGCTLYELYTGK 231 >4F9B-A nrPDB Length = 361 Score = 35.8 bits (81), Expect = 0.036, Method: Compositional matrix adjust. Identities = 35/127 (27%), Positives = 55/127 (43%), Gaps = 38/127 (29%) Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLS-----DFGLAR---DGPMGDLS 233 L+ K L +H +++RD+K SN L YN +L DFGLA+ D + L Sbjct: 124 LNLFKALKRIHQ--FGIVHRDVKPSNFL----YNRRLKKYALVDFGLAQGTHDTKIELLK 177 Query: 234 YVSTRVM-----------------------GTYGYAAPEYMSSG-HLNARSDVYSFGVLL 269 +V + GT G+ APE ++ + D++S GV+ Sbjct: 178 FVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIF 237 Query: 270 LEILSGK 276 L +LSG+ Sbjct: 238 LSLLSGR 244 >5X18-A nrPDB Length = 295 Score = 35.0 bits (79), Expect = 0.050, Method: Compositional matrix adjust. Identities = 48/159 (30%), Positives = 67/159 (42%), Gaps = 23/159 (14%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IGEG FG +F+G T G + I + E Q E+ T Y PN Sbjct: 15 IGEGSFGVLFEG-------TNMINGVPVAIKFEPRKTEAPQLRDEYKT---YKILNGTPN 64 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 + + E H +LV + + SLE+ G F V VA+ + LH Sbjct: 65 IPYAYYFGQEGLHNILVIDLLGP-SLEDLFDWCGRKFSVK---TVVQVAVQMITLIEDLH 120 Query: 193 SDPVKVIYRDIKASNILL------DADYNAKLSDFGLAR 225 + +IYRDIK N L+ DA+ N L DFG+A+ Sbjct: 121 AH--DLIYRDIKPDNFLIGRPGQPDAN-NIHLIDFGMAK 156 >4JRN-A nrPDB Length = 372 Score = 34.7 bits (78), Expect = 0.066, Method: Compositional matrix adjust. Identities = 25/83 (30%), Positives = 39/83 (46%), Gaps = 9/83 (10%) Query: 198 VIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPE--YMSSG- 254 +++ DIK +N LL D L DFG R ++ R +GT GY PE + ++G Sbjct: 223 IVHTDIKPANFLLLKDGRLFLGDFGTYR------INNSVGRAIGTPGYEPPERPFQATGI 276 Query: 255 HLNARSDVYSFGVLLLEILSGKR 277 +D + G+ L I +R Sbjct: 277 TYTFPTDAWQLGITLYCIWCKER 299 >4MD7-E nrPDB Length = 391 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 49/98 (50%), Gaps = 7/98 (7%) Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFGLARDGPMGDLSYVSTRVMGTYG 244 K L + HS + +++RD+K N+++D ++ +L D+GLA G + RV Y Sbjct: 142 KALDYCHS--MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG--QEYNVRVASRY- 196 Query: 245 YAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKRALDH 281 + PE + + S D++S G +L ++ K H Sbjct: 197 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234 >6EII-A nrPDB Length = 352 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 49/98 (50%), Gaps = 7/98 (7%) Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFGLARDGPMGDLSYVSTRVMGTYG 244 K L + HS + +++RD+K N+++D ++ +L D+GLA G + RV Y Sbjct: 165 KALDYCHS--MGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPG--QEYNVRVASRY- 219 Query: 245 YAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKRALDH 281 + PE + + S D++S G +L ++ K H Sbjct: 220 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 257 >3LLT-A nrPDB Length = 360 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 32/120 (26%), Positives = 49/120 (40%), Gaps = 32/120 (26%) Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY-------------------------N 215 ++ K L +L + + + D+K NILLD Y Sbjct: 143 CIEILKALNYLRK--MSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTG 200 Query: 216 AKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 KL DFG A S ++TR Y APE + + + SD++SFG +L E+ +G Sbjct: 201 IKLIDFGCATFKSDYHGSIINTR-----QYRAPEVILNLGWDVSSDMWSFGCVLAELYTG 255 >5GZ9-A nrPDB Length = 305 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 33/144 (22%), Positives = 59/144 (40%), Gaps = 20/144 (13%) Query: 55 FTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG 114 + EL+ R + +GEG VF E +A+ +L + + Sbjct: 27 LSCEELRTEVRQLKR---VGEGAVKRVFLSEWKEHK-----------VALSRLTR--LEM 70 Query: 115 HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLEN--HLFRRGAYFKPL 172 ++L + L L ++V L+GYC ED ++ E+ GSL N + Y Sbjct: 71 KEDFLHGLQMLKSLQSEHVVTLVGYCEEDG--TILTEYHPLGSLSNLEETLQLSKYQDVN 128 Query: 173 PWFLRVNVALDAAKGLAFLHSDPV 196 W R+ +A++ + +LH P+ Sbjct: 129 TWQHRLQLAMEYVSIINYLHHSPL 152 >2JD5-A nrPDB Length = 373 Score = 33.5 bits (75), Expect = 0.17, Method: Compositional matrix adjust. Identities = 23/90 (25%), Positives = 41/90 (45%), Gaps = 2/90 (2%) Query: 187 GLAFLHSDPVKVIYRDIKASNILLD-ADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGY 245 GL ++H +I+ DIK N+L++ D L +A G T + T Y Sbjct: 143 GLDYMHRR-CGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYTNSIQTREY 201 Query: 246 AAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 +PE + +D++S L+ E+++G Sbjct: 202 RSPEVLLGAPWGCGADIWSTACLIFELITG 231 >4LFI-A nrPDB Length = 374 Score = 33.5 bits (75), Expect = 0.18, Method: Compositional matrix adjust. Identities = 26/102 (25%), Positives = 53/102 (51%), Gaps = 7/102 (6%) Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLD-ADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 + K L + HS + +++RD+K N+++D + +L D+GLA + ++ Y + RV Sbjct: 179 FELLKALDYCHS--MGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-EFYHVNMEY-NVRVA 234 Query: 241 GTYGYAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKRALDH 281 + + PE + + S D++SFG +L ++ + H Sbjct: 235 SRF-FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 275 >5XVU-A nrPDB Length = 332 Score = 31.2 bits (69), Expect = 0.86, Method: Compositional matrix adjust. Identities = 28/96 (29%), Positives = 45/96 (46%), Gaps = 7/96 (7%) Query: 186 KGLAFLHSDPVKVIYRDIKASNILLD-ADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYG 244 K L + HS +++RD+K NI++D + +L +GLA G + RV Y Sbjct: 136 KALDYCHSQ--GIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPG--QEYNVRVASRY- 190 Query: 245 YAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKRAL 279 Y PE + L S D++S G +L ++ K Sbjct: 191 YKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPF 226 >5L3X-B nrPDB Length = 405 Score = 31.2 bits (69), Expect = 0.89, Method: Compositional matrix adjust. Identities = 22/70 (31%), Positives = 34/70 (48%), Gaps = 10/70 (14%) Query: 115 HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLEN-------HLFRRGA 167 H L EI+ QL HP +++L+ E EH L + M++ L+ HL RG Sbjct: 266 HLALLDEISTCHQLLHPQVLQLLVKLFETEHSAL--DVMEQLELKKTLLDRMVHLLSRG- 322 Query: 168 YFKPLPWFLR 177 Y P+ ++R Sbjct: 323 YVLPVVSYIR 332 >2CMW-A nrPDB Length = 310 Score = 30.8 bits (68), Expect = 1.0, Method: Compositional matrix adjust. Identities = 17/52 (32%), Positives = 28/52 (53%), Gaps = 7/52 (13%) Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAK-----LSDFGLARD 226 +A+ + ++HS +IYRD+K N L+ N K + DFGLA++ Sbjct: 102 IAIQLLSRMEYVHSK--NLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKE 151 >6GML-W nrPDB Length = 584 Score = 30.0 bits (66), Expect = 1.8, Method: Compositional matrix adjust. Identities = 22/70 (31%), Positives = 34/70 (48%), Gaps = 10/70 (14%) Query: 115 HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLEN-------HLFRRGA 167 H L EI+ QL HP +++L+ E EH L + M++ L+ HL RG Sbjct: 445 HLALLDEISTCHQLLHPQVLQLLVKLFETEHSQL--DVMEQLELKKTLLDRMVHLLSRG- 501 Query: 168 YFKPLPWFLR 177 Y P+ ++R Sbjct: 502 YVLPVVSYIR 511 >2X7G-A nrPDB Length = 389 Score = 30.0 bits (66), Expect = 2.0, Method: Compositional matrix adjust. Identities = 22/71 (30%), Positives = 36/71 (50%), Gaps = 8/71 (11%) Query: 145 HRLLVYEFMQKGSLENHLFRR--GAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRD 202 H +V+E L +HL + + ++ LP ++ +GL +LHS K+I+ D Sbjct: 113 HVCMVFEV-----LGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSK-CKIIHTD 166 Query: 203 IKASNILLDAD 213 IK NIL+ D Sbjct: 167 IKPENILMCVD 177 >6HMD-A nrPDB Length = 365 Score = 29.3 bits (64), Expect = 3.5, Method: Compositional matrix adjust. Identities = 26/99 (26%), Positives = 47/99 (47%), Gaps = 9/99 (9%) Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFGLAR-DGPMGDLSYVSTRVMGTY 243 K L + HS +++RD+K N+++D +L D+GLA P + + RV Y Sbjct: 158 KALDYCHSK--GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE---YNVRVASRY 212 Query: 244 GYAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKRALDH 281 + PE + + S D++S G +L ++ + H Sbjct: 213 -FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFH 250 >4XHL-A nrPDB Length = 394 Score = 28.9 bits (63), Expect = 3.8, Method: Compositional matrix adjust. Identities = 50/225 (22%), Positives = 82/225 (36%), Gaps = 36/225 (16%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 R FR IG G FG ++ G T G + I ++ + Q E Sbjct: 7 RKFRIGRKIGSGSFGDIYHG-------TNLISGEEVAIRLESIRSRHPQLDYESRVYRYL 59 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKG--SLENHLFRRGAYFKPLPWFLRVNVAL 182 G + P ++ G E E+ +V + + L N+ RR ++ + L++ + Sbjct: 60 SGGVGIP-FIRWFG--REGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRI 116 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILL------------DADYNAKLSDFGLARDGPMG 230 G +F+H RDIK N L+ D + K DF R P Sbjct: 117 QYIHGRSFIH--------RDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYR 168 Query: 231 DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 + + + GT YA+ + R D+ S G +L+ G Sbjct: 169 E----NKSLTGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCKG 209 >1V6C-A nrPDB Length = 441 Score = 28.9 bits (63), Expect = 4.2, Method: Compositional matrix adjust. Identities = 19/45 (42%), Positives = 24/45 (53%), Gaps = 5/45 (11%) Query: 56 TFNELKLATRNFRPDSVIGEGGFGCVF-KGWLDESTLTPTKPGTG 99 T ++L +A R D+ G G V K +LDES PT PGTG Sbjct: 401 TADDLSVAGR----DNQTGYGMINAVAAKAYLDESCTGPTDPGTG 441 >1CSN-A nrPDB Length = 298 Score = 28.9 bits (63), Expect = 4.6, Method: Compositional matrix adjust. Identities = 45/159 (28%), Positives = 66/159 (41%), Gaps = 23/159 (14%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IGEG FG +F+G T + I + + Q E+ T G PN Sbjct: 18 IGEGSFGVIFEG-------TNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPN 70 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 + + E H +LV + + SLE+ L G F VA+ A + LA + Sbjct: 71 VYY---FGQEGLHNVLVIDLLGP-SLEDLLDLCGRKFSV------KTVAMAAKQMLARVQ 120 Query: 193 SDPVK-VIYRDIKASNILLD--ADYNAKL---SDFGLAR 225 S K ++YRDIK N L+ NA + DFG+ + Sbjct: 121 SIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVK 159 >4XHH-A nrPDB Length = 403 Score = 28.5 bits (62), Expect = 5.3, Method: Compositional matrix adjust. Identities = 49/225 (21%), Positives = 82/225 (36%), Gaps = 36/225 (16%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 R FR IG G FG ++ G T G + I ++ + Q E Sbjct: 7 RKFRIGRKIGSGSFGDIYHG-------TNLISGEEVAIRLESIRSRHPQLDYESRVYKYL 59 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKG--SLENHLFRRGAYFKPLPWFLRVNVAL 182 G + P ++ G E E+ +V + + L N+ R+ ++ + L++ + Sbjct: 60 SGGVGIP-FIRWFG--REGEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICRV 116 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILL------------DADYNAKLSDFGLARDGPMG 230 G +F+H RDIK N L+ D + K DF R P Sbjct: 117 QYIHGRSFIH--------RDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYR 168 Query: 231 DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 + + + GT YA+ + R D+ S G +L+ G Sbjct: 169 E----NKSLTGTARYASVNTHLGIEQSRRDDLESLGYMLIYFCKG 209 >5G2X-C nrPDB Length = 599 Score = 28.1 bits (61), Expect = 6.1, Method: Compositional matrix adjust. Identities = 22/70 (31%), Positives = 36/70 (51%), Gaps = 6/70 (8%) Query: 95 KPGTGLVIAVKKLNQEGFQGHREWLTEINYLG---QLSHPNLVKLIGYCLED-EHRLLVY 150 +P A+K + +E F G R W E + G + H L+ LI ++D + L+Y Sbjct: 134 RPQRSCHTALKTIKRE-FGGAR-WFVEGDIKGCFDNIDHVTLIGLINLKIKDMKMSQLIY 191 Query: 151 EFMQKGSLEN 160 +F++ G LEN Sbjct: 192 KFLKAGYLEN 201 >2PVN-A nrPDB Length = 352 Score = 28.1 bits (61), Expect = 6.1, Method: Compositional matrix adjust. Identities = 25/98 (25%), Positives = 49/98 (50%), Gaps = 14/98 (14%) Query: 131 PNLVKLIGYCLEDEHRL---LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 PN+VKL+ + D+H L++E++ + Y + +R + + K Sbjct: 107 PNIVKLLD-IVRDQHSKTPSLIFEYVNNTDF------KVLYPTLTDYDIRYYI-YELLKA 158 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFGLA 224 L + HS +++RD+K N+++D + +L D+GLA Sbjct: 159 LDYCHSQ--GIMHRDVKPHNVMIDHELRKLRLIDWGLA 194 >2V3C-C nrPDB Length = 432 Score = 27.7 bits (60), Expect = 8.2, Method: Compositional matrix adjust. Identities = 15/41 (36%), Positives = 24/41 (58%), Gaps = 2/41 (4%) Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKL 218 +N AL+ K AF+ +K + +DI+ + L+ AD N KL Sbjct: 8 LNKALNKLKAAAFVDKKLIKEVIKDIQRA--LIQADVNVKL 46 >6ED3-A nrPDB Length = 848 Score = 27.7 bits (60), Expect = 9.1, Method: Compositional matrix adjust. Identities = 14/46 (30%), Positives = 27/46 (58%), Gaps = 1/46 (2%) Query: 309 DNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPT-MDQVVRALQQLQ 353 D + ++LP++A+ + A L E SRP +D+V R +++L+ Sbjct: 379 DRYITARFLPDKAIDLVDEAASRLRMEIDSRPVEIDEVERLVRRLE 424 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5TOS-A nrPDB 552 e-157 6J5U-C nrPDB 401 e-112 5LPZ-A nrPDB 285 2e-77 6BSD-A nrPDB 276 8e-75 5LPV-A nrPDB 275 3e-74 3UIM-A nrPDB 272 2e-73 4CSV-A nrPDB 269 1e-72 6FEX-A nrPDB 266 9e-72 3PPZ-A nrPDB 266 1e-71 2QKW-B nrPDB 262 2e-70 5XD6-A nrPDB 260 8e-70 4P5Q-A nrPDB 258 3e-69 3TT0-A nrPDB 256 1e-68 4XCU-A nrPDB 256 1e-68 6CTH-A nrPDB 256 1e-68 2PSQ-A nrPDB 256 2e-68 5A46-A nrPDB 255 3e-68 6GQK-A nrPDB 255 4e-68 1AD5-A nrPDB 254 5e-68 4AT3-A nrPDB 254 6e-68 1JPA-A nrPDB 254 6e-68 5JN2-A nrPDB 253 8e-68 3GQL-A nrPDB 253 8e-68 3V5Q-A nrPDB 253 9e-68 6DBM-A nrPDB 252 2e-67 2OGV-A nrPDB 252 2e-67 2PL0-A nrPDB 251 3e-67 3BEA-A nrPDB 251 5e-67 5KMM-A nrPDB 250 9e-67 3DKO-A nrPDB 250 1e-66 5AMN-A nrPDB 250 1e-66 3KRL-A nrPDB 249 1e-66 4GS6-A nrPDB 249 2e-66 4OLI-A nrPDB 248 2e-66 4XEY-B nrPDB 248 3e-66 4K33-A nrPDB 248 3e-66 2H8H-A nrPDB 247 5e-66 6FER-A nrPDB 247 5e-66 2FO0-A nrPDB 247 6e-66 2R2P-A nrPDB 247 6e-66 5MJB-A nrPDB 247 6e-66 3COM-A nrPDB 247 7e-66 6NPU-A nrPDB 247 8e-66 3A4O-X nrPDB 246 9e-66 1LUF-A nrPDB 246 9e-66 6F3F-A nrPDB 246 1e-65 4XLV-A nrPDB 246 1e-65 5EG3-A nrPDB 246 1e-65 2Y6O-A nrPDB 246 2e-65 5HVK-A nrPDB 246 2e-65 4UYA-A nrPDB 245 2e-65 5FM2-A nrPDB 245 2e-65 4R7H-A nrPDB 245 2e-65 4E93-A nrPDB 245 3e-65 5UIU-A nrPDB 244 3e-65 5L6P-A nrPDB 244 5e-65 5X5O-A nrPDB 244 6e-65 2XYN-A nrPDB 243 8e-65 5SYS-A nrPDB 243 8e-65 2VWV-A nrPDB 243 9e-65 3G0E-A nrPDB 243 9e-65 4UY9-A nrPDB 243 1e-64 3IO7-A nrPDB 243 1e-64 3I81-A nrPDB 243 1e-64 2DQ7-X nrPDB 243 1e-64 4PDO-A nrPDB 242 2e-64 2HK5-A nrPDB 242 2e-64 5X02-A nrPDB 242 2e-64 4XUF-A nrPDB 242 2e-64 2W1I-A nrPDB 241 3e-64 2J0K-A nrPDB 241 4e-64 4EBW-A nrPDB 241 4e-64 3KUL-B nrPDB 240 6e-64 3SXS-A nrPDB 240 7e-64 4H1J-A nrPDB 240 8e-64 4CFF-A nrPDB 240 1e-63 4E20-A nrPDB 239 2e-63 3DAK-A nrPDB 239 2e-63 4LG4-A nrPDB 238 2e-63 6GVJ-A nrPDB 238 2e-63 3CJF-A nrPDB 238 3e-63 6AO5-A nrPDB 238 4e-63 3BBT-B nrPDB 238 5e-63 5HLW-A nrPDB 237 6e-63 3ZBF-A nrPDB 237 6e-63 3QGY-A nrPDB 237 6e-63 3C1X-A nrPDB 236 1e-62 3DTC-A nrPDB 236 1e-62 5KCV-A nrPDB 236 2e-62 5H2U-A nrPDB 235 2e-62 5WNL-A nrPDB 235 3e-62 4QMW-A nrPDB 235 3e-62 4CFH-A nrPDB 235 3e-62 1K9A-A nrPDB 234 5e-62 1BYG-A nrPDB 234 5e-62 2XIK-A nrPDB 233 7e-62 6E9W-A nrPDB 233 1e-61 4HVI-A nrPDB 233 1e-61 5HIE-A nrPDB 232 2e-61 5ES1-A nrPDB 232 2e-61 2BPM-A nrPDB 231 3e-61 5GRN-A nrPDB 231 3e-61 5GNK-A nrPDB 231 5e-61 5HI2-A nrPDB 231 5e-61 5KZ7-A nrPDB 231 6e-61 3QUP-A nrPDB 230 7e-61 5EZV-A nrPDB 230 7e-61 3LZB-A nrPDB 230 8e-61 5DBX-A nrPDB 229 1e-60 2YZA-A nrPDB 229 1e-60 5VO2-A nrPDB 229 1e-60 4MVF-A nrPDB 229 1e-60 2QNJ-A nrPDB 229 2e-60 4Y93-A nrPDB 228 3e-60 2WQN-A nrPDB 228 4e-60 1FVR-A nrPDB 228 4e-60 6DBN-A nrPDB 227 6e-60 5U6C-A nrPDB 227 6e-60 4FZF-B nrPDB 227 8e-60 3PP0-A nrPDB 227 8e-60 4REW-A nrPDB 226 1e-59 2JDO-A nrPDB 226 2e-59 4HZS-A nrPDB 225 2e-59 1U54-B nrPDB 225 2e-59 6BFN-A nrPDB 225 3e-59 4RED-A nrPDB 225 3e-59 6E4F-A nrPDB 224 4e-59 2F57-A nrPDB 224 5e-59 4LRM-A nrPDB 224 5e-59 3MV5-A nrPDB 224 5e-59 4XI2-A nrPDB 224 6e-59 3NIZ-A nrPDB 224 6e-59 2HAK-A nrPDB 224 6e-59 5U6B-A nrPDB 224 7e-59 3AOX-A nrPDB 223 1e-58 3MN3-A nrPDB 223 1e-58 3OMV-A nrPDB 223 1e-58 3MA6-A nrPDB 223 2e-58 4F0G-A nrPDB 222 2e-58 3PLS-A nrPDB 222 2e-58 6C9D-A nrPDB 222 2e-58 5IG1-A nrPDB 222 3e-58 4JDH-A nrPDB 221 4e-58 5J5T-A nrPDB 221 4e-58 3Q5I-A nrPDB 221 4e-58 3NCG-A nrPDB 221 5e-58 2Q0N-A nrPDB 221 6e-58 6FD3-A nrPDB 220 6e-58 4XBR-A nrPDB 220 7e-58 4FIE-A nrPDB 220 7e-58 3HZT-A nrPDB 220 7e-58 2OZO-A nrPDB 220 8e-58 3Q53-A nrPDB 220 9e-58 2BDW-A nrPDB 220 9e-58 2Z7Q-A nrPDB 220 1e-57 3DXN-A nrPDB 220 1e-57 3ZZW-A nrPDB 220 1e-57 5XZW-A nrPDB 219 1e-57 4YFF-A nrPDB 219 1e-57 1U59-A nrPDB 219 1e-57 3KK8-A nrPDB 219 2e-57 2VN9-A nrPDB 219 2e-57 5FG8-A nrPDB 218 2e-57 4KS7-A nrPDB 218 3e-57 4CQG-A nrPDB 218 3e-57 3DFA-A nrPDB 218 3e-57 4KRC-A nrPDB 218 3e-57 3H4J-B nrPDB 218 3e-57 4TPT-A nrPDB 218 4e-57 2V7O-A nrPDB 218 4e-57 4RLP-A nrPDB 218 5e-57 4JXF-A nrPDB 218 5e-57 2JC6-A nrPDB 218 5e-57 4BBM-A nrPDB 217 5e-57 4FG9-A nrPDB 217 8e-57 4L42-A nrPDB 216 1e-56 5U6Y-A nrPDB 216 1e-56 2VZ6-A nrPDB 216 1e-56 2UV2-A nrPDB 216 1e-56 3IS5-A nrPDB 216 2e-56 4D2V-A nrPDB 215 2e-56 4AGU-A nrPDB 215 2e-56 6ED6-A nrPDB 215 2e-56 4CZT-A nrPDB 215 3e-56 3BHH-A nrPDB 215 3e-56 2W96-B nrPDB 215 3e-56 4UZD-A nrPDB 214 4e-56 4RGJ-A nrPDB 214 5e-56 3TXO-A nrPDB 214 5e-56 6FDY-U nrPDB 214 5e-56 5D7A-A nrPDB 214 5e-56 4D28-A nrPDB 214 6e-56 3VN9-A nrPDB 214 6e-56 5NGU-A nrPDB 213 9e-56 5D9K-A nrPDB 213 1e-55 6GU6-A nrPDB 212 2e-55 6HXF-B nrPDB 212 2e-55 3SOA-A nrPDB 212 2e-55 5LOH-A nrPDB 211 3e-55 3HDN-A nrPDB 211 3e-55 5F9E-A nrPDB 211 4e-55 3LIJ-A nrPDB 211 4e-55 1FOT-A nrPDB 211 5e-55 4WNO-A nrPDB 211 5e-55 4QTB-A nrPDB 211 5e-55 2JAM-A nrPDB 211 6e-55 5YKS-A nrPDB 211 6e-55 1U5R-A nrPDB 210 9e-55 6QAU-A nrPDB 210 9e-55 4RA4-A nrPDB 210 1e-54 4NEU-A nrPDB 210 1e-54 2GCD-A nrPDB 209 2e-54 4L68-A nrPDB 209 2e-54 6BDL-A nrPDB 209 2e-54 1V0B-A nrPDB 209 2e-54 3D2K-A nrPDB 209 2e-54 4YZB-A nrPDB 209 2e-54 2F9G-A nrPDB 209 2e-54 1VZO-A nrPDB 208 3e-54 6DTL-A nrPDB 208 5e-54 2W4O-A nrPDB 207 6e-54 4APC-A nrPDB 207 6e-54 1G3N-A nrPDB 207 7e-54 3TAC-A nrPDB 207 7e-54 3ZDU-A nrPDB 207 9e-54 2J90-A nrPDB 206 1e-53 3F3Z-A nrPDB 206 1e-53 4B6L-A nrPDB 206 1e-53 3A8W-A nrPDB 206 2e-53 6CQF-A nrPDB 206 2e-53 5WNO-A nrPDB 205 2e-53 5WAX-A nrPDB 205 2e-53 4IC8-A nrPDB 205 3e-53 4PDS-A nrPDB 205 3e-53 4U41-A nrPDB 204 4e-53 4YNZ-A nrPDB 204 4e-53 3FME-A nrPDB 204 5e-53 4ZSG-A nrPDB 204 5e-53 1CM8-A nrPDB 204 6e-53 3UC3-A nrPDB 204 6e-53 4WB7-A nrPDB 203 1e-52 5EFQ-A nrPDB 203 1e-52 4MYG-A nrPDB 203 2e-52 3DB8-A nrPDB 203 2e-52 4QNY-A nrPDB 202 2e-52 2X4F-A nrPDB 202 2e-52 4AN9-A nrPDB 202 2e-52 4EWQ-A nrPDB 202 3e-52 2XNP-A nrPDB 202 3e-52 3ALO-A nrPDB 201 3e-52 5Z33-A nrPDB 201 3e-52 3UDB-A nrPDB 201 4e-52 3ZUT-A nrPDB 201 4e-52 5FET-A nrPDB 201 4e-52 2I0E-A nrPDB 201 4e-52 2BRG-A nrPDB 201 4e-52 3PFQ-A nrPDB 201 5e-52 4NST-A nrPDB 201 5e-52 4BGQ-A nrPDB 201 5e-52 1UA2-A nrPDB 201 6e-52 5N23-A nrPDB 200 8e-52 4I6B-A nrPDB 200 8e-52 3OHT-A nrPDB 200 9e-52 4AU8-A nrPDB 200 9e-52 5X3F-B nrPDB 200 1e-51 4AW2-A nrPDB 199 1e-51 5JZN-A nrPDB 199 2e-51 4NIF-A nrPDB 199 2e-51 2Y7J-A nrPDB 199 2e-51 4FR4-A nrPDB 199 2e-51 5DYK-A nrPDB 199 3e-51 6E2O-A nrPDB 198 3e-51 3Q4U-A nrPDB 198 3e-51 3ORZ-A nrPDB 198 3e-51 1PHK-A nrPDB 198 4e-51 3GC9-A nrPDB 198 4e-51 3GUB-A nrPDB 198 4e-51 3LMG-A nrPDB 198 5e-51 5KKR-C nrPDB 197 6e-51 3TKU-A nrPDB 197 6e-51 4JG6-A nrPDB 197 6e-51 2YAB-A nrPDB 197 7e-51 4I94-A nrPDB 197 8e-51 6CMJ-A nrPDB 197 8e-51 5AWM-A nrPDB 197 9e-51 2OU7-A nrPDB 197 9e-51 4B8L-A nrPDB 197 9e-51 4J52-A nrPDB 196 1e-50 3EQC-A nrPDB 196 1e-50 5G6V-A nrPDB 196 1e-50 4FL3-A nrPDB 196 2e-50 3LM0-A nrPDB 196 2e-50 2BUJ-A nrPDB 195 2e-50 2A27-A nrPDB 194 4e-50 5C26-A nrPDB 194 5e-50 3NYO-A nrPDB 194 5e-50 1ZWS-A nrPDB 193 1e-49 2YCR-A nrPDB 193 1e-49 5AP3-A nrPDB 193 1e-49 4TNB-A nrPDB 192 1e-49 5YV8-A nrPDB 192 2e-49 3OZ6-A nrPDB 192 2e-49 4EQM-A nrPDB 192 3e-49 6BXI-A nrPDB 191 4e-49 2XS0-A nrPDB 191 6e-49 1S9I-A nrPDB 190 7e-49 1PY5-A nrPDB 190 8e-49 4IDT-A nrPDB 190 9e-49 3MDY-A nrPDB 190 1e-48 3KN6-A nrPDB 190 1e-48 3E7O-A nrPDB 189 1e-48 3I6U-A nrPDB 189 2e-48 6J6I-B nrPDB 189 2e-48 3HMP-A nrPDB 189 2e-48 4AF3-A nrPDB 189 2e-48 1JNK-A nrPDB 188 3e-48 3UTO-A nrPDB 188 3e-48 3FI2-A nrPDB 188 4e-48 3MY0-A nrPDB 187 5e-48 4M7I-A nrPDB 187 6e-48 2ZMD-A nrPDB 187 7e-48 5UUU-A nrPDB 187 8e-48 2A1A-B nrPDB 187 9e-48 2HW6-A nrPDB 187 1e-47 1KOA-A nrPDB 186 1e-47 3PVW-A nrPDB 186 1e-47 3C51-A nrPDB 186 2e-47 5O2B-A nrPDB 186 2e-47 5AR8-A nrPDB 185 3e-47 4OTD-A nrPDB 185 3e-47 1KOB-A nrPDB 185 3e-47 4C59-A nrPDB 185 3e-47 2I6L-A nrPDB 185 3e-47 4C0T-A nrPDB 184 4e-47 5O2C-A nrPDB 184 4e-47 4KIK-B nrPDB 184 5e-47 4PWN-A nrPDB 184 6e-47 3SOC-A nrPDB 184 6e-47 3PG1-A nrPDB 183 1e-46 5AIR-A nrPDB 183 1e-46 3MIA-A nrPDB 182 2e-46 4O2Z-A nrPDB 182 2e-46 5O0Y-A nrPDB 182 2e-46 4X7Q-B nrPDB 182 3e-46 2VD5-A nrPDB 182 3e-46 4M66-A nrPDB 181 3e-46 3RP9-A nrPDB 181 3e-46 3QA8-A nrPDB 181 5e-46 3UIU-A nrPDB 181 5e-46 5E8V-A nrPDB 180 1e-45 3GC0-A nrPDB 180 1e-45 6CCF-A nrPDB 180 1e-45 4CRS-A nrPDB 179 2e-45 4YHJ-A nrPDB 179 2e-45 5Y86-A nrPDB 179 2e-45 1ZXE-A nrPDB 178 3e-45 5TQX-A nrPDB 178 4e-45 5ZTN-A nrPDB 177 5e-45 3BGP-A nrPDB 177 5e-45 3G2F-A nrPDB 177 7e-45 3FXW-A nrPDB 177 8e-45 4E7W-A nrPDB 177 9e-45 2Y4I-B nrPDB 176 1e-44 3ORP-A nrPDB 176 1e-44 4RC3-A nrPDB 176 2e-44 3REP-A nrPDB 176 2e-44 3N9X-A nrPDB 176 2e-44 3E3P-A nrPDB 175 2e-44 5TUR-A nrPDB 175 3e-44 6EAS-A nrPDB 174 4e-44 5B2L-A nrPDB 174 5e-44 2QLU-A nrPDB 174 8e-44 6CKI-A nrPDB 173 9e-44 5USZ-A nrPDB 173 1e-43 4MWI-A nrPDB 171 4e-43 1NY3-A nrPDB 171 5e-43 3KA0-A nrPDB 171 5e-43 4L00-A nrPDB 171 6e-43 2OZA-A nrPDB 171 6e-43 4G3E-A nrPDB 169 2e-42 4Y83-A nrPDB 169 2e-42 4BTF-A nrPDB 168 3e-42 3NIE-A nrPDB 168 4e-42 4M69-B nrPDB 168 4e-42 5UV4-A nrPDB 166 1e-41 3EB0-A nrPDB 166 2e-41 3HNG-A nrPDB 166 2e-41 5J0A-A nrPDB 165 3e-41 3DLS-A nrPDB 165 4e-41 6O6Q-A nrPDB 164 4e-41 5TE0-A nrPDB 163 1e-40 5X8I-B nrPDB 162 2e-40 2RIO-A nrPDB 162 2e-40 6B2Q-A nrPDB 162 3e-40 4X3F-A nrPDB 162 3e-40 4OW8-A nrPDB 162 3e-40 6FYV-A nrPDB 161 4e-40 2WO6-A nrPDB 161 7e-40 6HV0-A nrPDB 161 7e-40 3VHK-A nrPDB 160 9e-40 5IKW-A nrPDB 160 1e-39 4PL5-B nrPDB 158 4e-39 4CRL-A nrPDB 157 6e-39 4LQP-A nrPDB 157 7e-39 5VD3-A nrPDB 157 9e-39 4JLC-A nrPDB 154 5e-38 2H34-A nrPDB 154 8e-38 2WTK-B nrPDB 153 1e-37 4EUU-A nrPDB 153 1e-37 4EUT-A nrPDB 153 1e-37 6O8B-A nrPDB 152 2e-37 4RT7-A nrPDB 152 3e-37 6NT9-A nrPDB 152 4e-37 5C01-A nrPDB 149 2e-36 4WOV-A nrPDB 147 7e-36 2PMN-X nrPDB 144 7e-35 3QD2-B nrPDB 142 3e-34 5GZA-A nrPDB 141 5e-34 5VC6-A nrPDB 135 2e-32 5X1R-A nrPDB 130 8e-31 5CLR-A nrPDB 83 2e-16 Sequences not found previously or not previously below threshold: 3HKO-A nrPDB 174 6e-44 2WTK-C nrPDB 165 3e-41 1TKI-A nrPDB 154 9e-38 4IAN-A nrPDB 145 4e-35 5UNP-A nrPDB 144 9e-35 3RAW-A nrPDB 141 6e-34 3M42-A nrPDB 140 9e-34 5VDK-A nrPDB 132 2e-31 3LLT-A nrPDB 129 1e-30 4WUA-A nrPDB 129 2e-30 2JD5-A nrPDB 126 1e-29 2X7G-A nrPDB 122 2e-28 4MD7-E nrPDB 122 4e-28 6HMD-A nrPDB 120 1e-27 5XVU-A nrPDB 120 1e-27 2PVN-A nrPDB 119 2e-27 6EII-A nrPDB 119 2e-27 4F9B-A nrPDB 119 2e-27 4LFI-A nrPDB 110 1e-24 5M07-A nrPDB 110 1e-24 5L2Q-C nrPDB 106 2e-23 4NFN-A nrPDB 105 5e-23 4BTK-A nrPDB 105 5e-23 6DC0-A nrPDB 101 5e-22 5CEK-A nrPDB 101 6e-22 2PZI-A nrPDB 100 2e-21 4Y12-A nrPDB 100 2e-21 5OAT-A nrPDB 98 7e-21 3SV0-A nrPDB 93 2e-19 5X18-A nrPDB 92 3e-19 5GZ9-A nrPDB 91 1e-18 5FQD-C nrPDB 90 1e-18 4TN6-A nrPDB 90 2e-18 4XHH-A nrPDB 86 2e-17 2C47-A nrPDB 85 4e-17 6EQI-C nrPDB 85 5e-17 2CHL-A nrPDB 85 7e-17 2CMW-A nrPDB 84 1e-16 4XHL-A nrPDB 81 6e-16 4NT4-A nrPDB 81 1e-15 4JRN-A nrPDB 79 3e-15 1CSN-A nrPDB 79 4e-15 5DMZ-A nrPDB 78 6e-15 5UU1-A nrPDB 72 4e-13 4OAU-C nrPDB 65 4e-11 2RSV-A nrPDB 64 8e-11 2LAV-A nrPDB 64 1e-10 4O1O-A nrPDB 64 1e-10 6G4J-A nrPDB 61 9e-10 4IX6-A nrPDB 60 1e-09 6M7Z-A nrPDB 58 6e-09 6EWX-A nrPDB 57 2e-08 6BHC-A nrPDB 56 2e-08 4CI6-B nrPDB 55 5e-08 2JII-A nrPDB 54 1e-07 4AZW-A nrPDB 50 2e-06 4AZV-A nrPDB 49 4e-06 5VE6-A nrPDB 46 3e-05 3ENH-A nrPDB 46 3e-05 6G38-A nrPDB 44 1e-04 4CYJ-A nrPDB 44 2e-04 3BYV-A nrPDB 43 3e-04 4BWP-A nrPDB 42 3e-04 3DZO-A nrPDB 42 4e-04 4WWA-A nrPDB 41 8e-04 2W1Z-A nrPDB 38 0.009 5YK0-A nrPDB 37 0.010 1TQM-A nrPDB 37 0.012 3Q60-A nrPDB 36 0.027 4CZY-B nrPDB 35 0.044 6DFL-A nrPDB 35 0.065 6GL3-A nrPDB 34 0.14 5C4G-E nrPDB 34 0.15 4D0L-A nrPDB 34 0.15 6GML-W nrPDB 33 0.21 5L3X-B nrPDB 33 0.25 6G18-v nrPDB 31 0.91 4BVU-A nrPDB 31 0.98 6FDN-A nrPDB 31 1.0 >5TOS-A nrPDB Length = 395 Score = 552 bits (1422), Expect = e-157, Method: Composition-based stats. Identities = 395/395 (100%), Positives = 395/395 (100%) Query: 1 MGSCFSSRVKADIFHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNEL 60 MGSCFSSRVKADIFHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNEL Sbjct: 1 MGSCFSSRVKADIFHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNEL 60 Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT Sbjct: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV Sbjct: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM Sbjct: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS Sbjct: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 Query: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPS 360 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPS Sbjct: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPS 360 Query: 361 QTNPVKDTKKLGFKTGTTKSSEKRFTQKPFGRHLV 395 QTNPVKDTKKLGFKTGTTKSSEKRFTQKPFGRHLV Sbjct: 361 QTNPVKDTKKLGFKTGTTKSSEKRFTQKPFGRHLV 395 >6J5U-C nrPDB Length = 426 Score = 401 bits (1030), Expect = e-112, Method: Composition-based stats. Identities = 215/409 (52%), Positives = 289/409 (70%), Gaps = 22/409 (5%) Query: 1 MGSCFSSRVKAD----IFHNGKSSDLYGLSLSSRKSSSTV---------------AAAQK 41 MG+C S K D H +S +S + +S+ + Sbjct: 1 MGNCLDSSAKVDNSNHSPHANSASSGSKVSSKTSRSTGPSGLSTTSYSTDSSFGPLPTLR 60 Query: 42 TEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLV 101 TEGEILSS +K+FTFNELK AT+NFR D+++GEGGFGCVFKGW+D+++LT ++PG+G+V Sbjct: 61 TEGEILSSPNLKAFTFNELKNATKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIV 120 Query: 102 IAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENH 161 +AVK+L EGFQGH+EWLTE+NYLGQLSHPNLV L+GYC E E+RLLVYEFM KGSLENH Sbjct: 121 VAVKQLKPEGFQGHKEWLTEVNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENH 180 Query: 162 LFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDF 221 LFRRGA +PL W +R+ VA+ AAKGL FLH +VIYRD KA+NILLDAD+NAKLSDF Sbjct: 181 LFRRGA--QPLTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDF 238 Query: 222 GLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDH 281 GLA+ GP GD ++VST+V+GT+GYAAPEY+++G L A+SDVYSFGV+LLE++SG+RA+D+ Sbjct: 239 GLAKAGPTGDNTHVSTKVIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDN 298 Query: 282 NRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPT 341 + E +LVDWA PYL KRK+ I+D +L QY + A A++A+QCL+ + K RP Sbjct: 299 SNGGNEYSLVDWATPYLGDKRKLFRIMDTKLGGQYPQKGAFTAANLALQCLNPDAKLRPK 358 Query: 342 MDQVVRALQQLQDNLGKPSQTNPVKDTKKLGFKTGTTKSSEKRFTQKPF 390 M +V+ L+QL +++ KP + ++ + + KS + +P Sbjct: 359 MSEVLVTLEQL-ESVAKPGTKHTQMESPRFHHSSVMQKSPVRYSHDRPL 406 >5LPZ-A nrPDB Length = 332 Score = 285 bits (730), Expect = 2e-77, Method: Composition-based stats. Identities = 123/330 (37%), Positives = 181/330 (54%), Gaps = 13/330 (3%) Query: 49 STPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN 108 P++ F +L AT F DS+IG GGFG V+K L + G +A+KKL Sbjct: 1 EKPLRKLAFADLLQATNGFHNDSLIGSGGFGDVYKAILKD----------GSAVAIKKLI 50 Query: 109 QEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAY 168 QG RE++ E+ +G++ H NLV L+GYC + RLLVYEFM+ GSLE+ L Sbjct: 51 HVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKA 110 Query: 169 FKPLPWFLRVNVALDAAKGLAFLHSDP-VKVIYRDIKASNILLDADYNAKLSDFGLARDG 227 L W R +A+ +A+GLAFLH + +I+RD+K+SN+LLD + A++SDFG+AR Sbjct: 111 GVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLM 170 Query: 228 PMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE 287 D + + GT GY PEY S + + DVYS+GV+LLE+L+GKR D + + Sbjct: 171 SAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTD-SPDFGD 229 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 NLV W + + + + + + L E ++ VAV CL RPTM QV+ Sbjct: 230 NNLVGWVKQHAKLRISDVFDPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVMA 289 Query: 348 ALQQLQDNLGKPSQTNPVKDTKKLGFKTGT 377 +++Q G SQ + ++ + GF T Sbjct: 290 MFKEIQAGSGIDSQ-STIRSIEDGGFSTIE 318 >6BSD-A nrPDB Length = 876 Score = 276 bits (707), Expect = 8e-75, Method: Composition-based stats. Identities = 80/350 (22%), Positives = 147/350 (42%), Gaps = 40/350 (11%) Query: 25 LSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKG 84 ++L +T A G + P F R +GEG FG V Sbjct: 538 VTLQGVTGGNTYAVPALPPGAVGDGPPRVDF-------PRSRLRFKEKLGEGQFGEVHLC 590 Query: 85 WLDEST-------LTPTKPGTGLVIAVKKLNQEGFQGHR-EWLTEINYLGQLSHPNLVKL 136 +D + G L++AVK L + + R ++L E+ + +L PN+++L Sbjct: 591 EVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRL 650 Query: 137 IGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFK---------------PLPWFLRVNVA 181 +G C++D+ ++ ++M+ G L L K + + + ++VA Sbjct: 651 LGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVA 710 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 A G+ +L + + ++RD+ N L+ ++ K++DFG++R+ GD V R + Sbjct: 711 AQIASGMRYLAT--LNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVL 768 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK 301 + A E + G SDV++FGV L E+L RA + E+ + + + Sbjct: 769 PIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQG 828 Query: 302 RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 R+V L P + + ++C S E + RP Q+ R L + Sbjct: 829 RQVYL--------SRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAE 870 >5LPV-A nrPDB Length = 296 Score = 275 bits (703), Expect = 3e-74, Method: Composition-based stats. Identities = 117/306 (38%), Positives = 171/306 (55%), Gaps = 12/306 (3%) Query: 49 STPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN 108 P++ F +L AT F DS+IG GGFG V+K L + G +A+KKL Sbjct: 1 EKPLRKLAFADLLQATNGFHNDSLIGSGGFGDVYKAILKD----------GSAVAIKKLI 50 Query: 109 QEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAY 168 QG RE++ E+ +G++ H NLV L+GYC + RLLVYEFM+ GSLE+ L Sbjct: 51 HVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMKYGSLEDVLHDPKKA 110 Query: 169 FKPLPWFLRVNVALDAAKGLAFLHSDP-VKVIYRDIKASNILLDADYNAKLSDFGLARDG 227 L W R +A+ +A+GLAFLH + +I+RD+K+SN+LLD + A++SDFG+AR Sbjct: 111 GVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLM 170 Query: 228 PMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE 287 D + + GT GY PEY S + + DVYS+GV+LLE+L+GKR D + + Sbjct: 171 SAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTD-SPDFGD 229 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 NLV W + + + + + + L E ++ VAV CL RPTM QV+ Sbjct: 230 NNLVGWVKQHAKLRISDVFDPELMKEDPALEIELLQHLKVAVACLDDRAWRRPTMVQVMA 289 Query: 348 ALQQLQ 353 +++Q Sbjct: 290 MFKEIQ 295 >3UIM-A nrPDB Length = 326 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 120/316 (37%), Positives = 188/316 (59%), Gaps = 16/316 (5%) Query: 39 AQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGT 98 E + +K F+ EL++A+ NF +++G GGFG V+KG L + Sbjct: 4 VPAEEDPEVHLGQLKRFSLRELQVASDNFSNKNILGRGGFGKVYKGRLAD---------- 53 Query: 99 GLVIAVKKLNQEGFQGHR-EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGS 157 G ++AVK+L +E QG ++ TE+ + H NL++L G+C+ RLLVY +M GS Sbjct: 54 GTLVAVKRLKEERTQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGS 113 Query: 158 LENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDP-VKVIYRDIKASNILLDADYNA 216 + + L R PL W R +AL +A+GLA+LH K+I+RD+KA+NILLD ++ A Sbjct: 114 VASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEA 173 Query: 217 KLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 + DFGLA+ D ++V+T V GT G+ APEY+S+G + ++DV+ +GV+LLE+++G+ Sbjct: 174 VVGDFGLAKLMDYKD-THVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQ 232 Query: 277 RALDHNRPAKEEN--LVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSF 334 RA D R A +++ L+DW + L ++K+ +VD L Y EE ++ VA+ C Sbjct: 233 RAFDLARLANDDDVMLLDWVKG-LLKEKKLEALVDVDLQGNYKDEEVEQLIQVALLCTQS 291 Query: 335 EPKSRPTMDQVVRALQ 350 P RP M +VVR L+ Sbjct: 292 SPMERPKMSEVVRMLE 307 >4CSV-A nrPDB Length = 275 Score = 269 bits (688), Expect = 1e-72, Method: Composition-based stats. Identities = 74/298 (24%), Positives = 133/298 (44%), Gaps = 33/298 (11%) Query: 56 TFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH 115 ++ ++ + +G G FG V++G + +AVK L +EG Sbjct: 2 PHDKWEIPRSEITLERKLGSGQFGEVYEGKWRNY---------NIEVAVKTL-KEGTMSV 51 Query: 116 REWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 E+L E + +L HPNLV+L G C ++ ++ E+M GSL ++L + + Sbjct: 52 EEFLQEAQIMKKLKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHT--VNAQ 109 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 +++A A G+A+L S I+RD+ A N L+ + K++DFGLAR + + Sbjct: 110 ALLDMAAQVASGMAYLESQ--NFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTAR 167 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWA 294 + + APE +S + +SDV++FG+LL EI + G+ Sbjct: 168 A-GAKFPIKWTAPEAISYNRFSIKSDVWAFGILLWEIFTYGQVPYPG------------- 213 Query: 295 RPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 S +V+ V+ + + +QC + P+ RPT + + AL+ + Sbjct: 214 ----MSGSEVIEQVERGYRMPRPQGCPEEIYELMLQCWNKSPEERPTFAETLHALETM 267 >6FEX-A nrPDB Length = 321 Score = 266 bits (681), Expect = 9e-72, Method: Composition-based stats. Identities = 77/326 (23%), Positives = 141/326 (43%), Gaps = 34/326 (10%) Query: 43 EGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDEST-------LTPTK 95 G + P F R +GEG FG V +D + Sbjct: 1 PGAVGDGPPRVDF-------PRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVR 53 Query: 96 PGTGLVIAVKKLNQEGFQGHR-EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQ 154 G L++AVK L + + R ++L E+ + +L PN+++L+G C++D+ ++ ++M+ Sbjct: 54 KGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYME 113 Query: 155 KGSLENHLFRRGAYFK---------PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKA 205 G L L K + + + ++VA A G+ +L + + ++RD+ Sbjct: 114 NGDLNQFLSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLAT--LNFVHRDLAT 171 Query: 206 SNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSF 265 N L+ ++ K++DFG++R+ GD V R + + A E + G SDV++F Sbjct: 172 RNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAF 231 Query: 266 GVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMA 325 GV L E+L RA + E+ + + + R+V L P + Sbjct: 232 GVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYL--------SRPPACPQGLY 283 Query: 326 SVAVQCLSFEPKSRPTMDQVVRALQQ 351 + ++C S E + RP Q+ R L + Sbjct: 284 ELMLRCWSRESEQRPPFSQLHRFLAE 309 >3PPZ-A nrPDB Length = 309 Score = 266 bits (679), Expect = 1e-71, Method: Composition-based stats. Identities = 83/304 (27%), Positives = 143/304 (47%), Gaps = 32/304 (10%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR- 116 +++ + + IG G FG V + G +AVK L ++ F R Sbjct: 30 DDMDIPWCDLNIKEKIGAGSFGTVHRAEWH-----------GSDVAVKILMEQDFHAERV 78 Query: 117 -EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 E+L E+ + +L HPN+V +G + + +V E++ +GSL L + GA + L Sbjct: 79 NEFLREVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAR-EQLDER 137 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 R+++A D AKG+ +LH+ +++RD+K+ N+L+D Y K+ DFGL+R Sbjct: 138 RRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLK--ASTFLS 195 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 S GT + APE + N +SDVYSFGV+L E+ + ++ + PA+ V + Sbjct: 196 SKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKC 255 Query: 296 PYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 L R + ++A++ C + EP RP+ ++ L+ L + Sbjct: 256 KRLEIPRNLN----------------PQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIKS 299 Query: 356 LGKP 359 P Sbjct: 300 AVPP 303 >2QKW-B nrPDB Length = 321 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 116/331 (35%), Positives = 183/331 (55%), Gaps = 21/331 (6%) Query: 33 SSTVAAAQKTEGEILSSTPVKSF-----TFNELKLATRNFRPDSVIGEGGFGCVFKGWLD 87 S + A + + LSS+ + F +L+ AT NF +IG G FG V+KG L Sbjct: 2 GSKYSKATNSINDALSSSYLVPFESYRVPLVDLEEATNNFDHKFLIGHGVFGKVYKGVLR 61 Query: 88 ESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRL 147 + G +A+K+ E QG E+ TEI L HP+LV LIG+C E + Sbjct: 62 D----------GAKVALKRRTPESSQGIEEFETEIETLSFCRHPHLVSLIGFCDERNEMI 111 Query: 148 LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASN 207 L+Y++M+ G+L+ HL+ + W R+ + + AA+GL +LH+ +I+RD+K+ N Sbjct: 112 LIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRA--IIHRDVKSIN 169 Query: 208 ILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGV 267 ILLD ++ K++DFG+++ G D +++ST V GT GY PEY G L +SDVYSFGV Sbjct: 170 ILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRLTEKSDVYSFGV 229 Query: 268 LLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASV 327 +L E+L + A+ + P + NL +WA + ++ IVD L + PE + Sbjct: 230 VLFEVLCARSAIVQSLPREMVNLAEWAVES-HNNGQLEQIVDPNLADKIRPESLRKFGDT 288 Query: 328 AVQCLSFEPKSRPTMDQVVRALQ---QLQDN 355 AV+CL+ + RP+M V+ L+ +LQ++ Sbjct: 289 AVKCLALSSEDRPSMGDVLWKLEYALRLQES 319 >5XD6-A nrPDB Length = 305 Score = 260 bits (664), Expect = 8e-70, Method: Composition-based stats. Identities = 125/307 (40%), Positives = 183/307 (59%), Gaps = 18/307 (5%) Query: 52 VKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEG 111 V + +EL+ T N+ S+IGEG +G VF G L +G A+KKL+ Sbjct: 9 VAAIPADELRDITDNYGSKSLIGEGSYGRVFYGILK----------SGKAAAIKKLDSSK 58 Query: 112 FQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAY--- 168 Q +E+L +++ + +L N+V L+GYC++ R+L YE+ GSL + L R Sbjct: 59 -QPDQEFLAQVSMVSRLRQENVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGA 117 Query: 169 --FKPLPWFLRVNVALDAAKGLAFLHSD-PVKVIYRDIKASNILLDADYNAKLSDFGLAR 225 L W RV +A+ AA+GL +LH VI+RDIK+SN+LL D AK++DF L+ Sbjct: 118 QPGPVLSWHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSN 177 Query: 226 DGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPA 285 P STRV+GT+GY APEY +G L+ +SDVYSFGV+LLE+L+G++ +DH P Sbjct: 178 QAPDMAARLHSTRVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKPVDHTLPR 237 Query: 286 KEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQV 345 ++++V WA P L S+ KV VD RL+ +Y P+ ++A+VA C+ +E RP M V Sbjct: 238 GQQSVVTWATPKL-SEDKVKQCVDARLNGEYPPKAVAKLAAVAALCVQYEADFRPNMSIV 296 Query: 346 VRALQQL 352 V+ALQ L Sbjct: 297 VKALQPL 303 >4P5Q-A nrPDB Length = 361 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 77/301 (25%), Positives = 139/301 (46%), Gaps = 31/301 (10%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ-EGFQGHREWL 119 +L N D V+G G FG V G L + + +A+K L + R++L Sbjct: 29 ELDATNISIDKVVGAGEFGEVCSGRLKLPSKKE------ISVAIKTLKVGYTEKQRRDFL 82 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 E + +GQ HPN+++L G + + ++V E+M+ GSL++ L + A F + V Sbjct: 83 GEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVI---QLVG 139 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR- 238 + A G+ +L + ++RD+ A NIL++++ K+SDFGL+R + +TR Sbjct: 140 MLRGIASGMKYL--SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG 197 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPY 297 + +PE ++ + SDV+S+G++L E++S G+R Sbjct: 198 GKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWE---------------- 241 Query: 298 LTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLG 357 S + V+ VD + + + + C + +RP +Q+V L +L N G Sbjct: 242 -MSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPG 300 Query: 358 K 358 Sbjct: 301 S 301 >3TT0-A nrPDB Length = 382 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 75/308 (24%), Positives = 122/308 (39%), Gaps = 36/308 (11%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-REW 118 +L +GEG FG V + L KP +AVK L + + + Sbjct: 64 WELPRDRLVLGKPLGEGAFGQVVLA--EAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDL 121 Query: 119 LTEINYLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF-------- 169 ++E+ + + H N++ L+G C +D ++ E+ KG+L +L R Sbjct: 122 ISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPS 181 Query: 170 ----KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR 225 + L V+ A A+G+ +L S K I+RD+ A N+L+ D K++DFGLAR Sbjct: 182 HNPEEQLSSKDLVSCAYQVARGMEYLASK--KCIHRDLAARNVLVTEDNVMKIADFGLAR 239 Query: 226 DGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRP 284 D D +T + APE + +SDV+SFGVLL EI + G Sbjct: 240 DIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVP- 298 Query: 285 AKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQ 344 ++ ++ + + C P RPT Q Sbjct: 299 ----------------VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 342 Query: 345 VVRALQQL 352 +V L ++ Sbjct: 343 LVEDLDRI 350 >4XCU-A nrPDB Length = 300 Score = 256 bits (653), Expect = 1e-68, Method: Composition-based stats. Identities = 73/299 (24%), Positives = 125/299 (41%), Gaps = 27/299 (9%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-REW 118 + +GEG FG V + + + P +P +AVK L + Sbjct: 12 WEFPRDRLVLGKPLGEGCFGQVVRA--EAFGMDPARPDQASTVAVKMLKDNASDKDLADL 69 Query: 119 LTEINYLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR---GAYFKPLPW 174 ++E+ + + H N++ L+G C ++ ++ E KG+L L R G+ PL + Sbjct: 70 VSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSF 129 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSY 234 + V+ A A+G+ +L S K I+RD+ A N+L+ D K++DFGLAR D Sbjct: 130 PVLVSCAYQVARGMQYLESR--KCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYK 187 Query: 235 VSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDW 293 ++ + APE + +SDV+SFG+LL EI + G Sbjct: 188 KTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIP---------- 237 Query: 294 ARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 ++ ++ P + + +C P RPT Q+V AL ++ Sbjct: 238 -------VEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKV 289 >6CTH-A nrPDB Length = 309 Score = 256 bits (653), Expect = 1e-68, Method: Composition-based stats. Identities = 115/300 (38%), Positives = 171/300 (57%), Gaps = 14/300 (4%) Query: 52 VKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEG 111 ++ F+ NEL T NF ++ +GEGGFG V++G+L +S IAVKK+++ Sbjct: 2 MRKFSLNELAKVTSNFNAENKLGEGGFGSVYRGFLRDSDT---------YIAVKKVSRAS 52 Query: 112 FQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKP 171 QG +E+ +E+ + +L H NLVKLIG+C E +LVYEFM GSL++H+F+ + Sbjct: 53 KQGIKEYASEVKIISRLRHKNLVKLIGWCHERGELMLVYEFMANGSLDSHIFKGKSL--- 109 Query: 172 LPWFLRVNVALDAAKGLAFLHSDPVK-VIYRDIKASNILLDADYNAKLSDFGLARDGPMG 230 L W +R + D A L +LH + V++RDIK SNI+LD+ +NAKL DFGLAR Sbjct: 110 LTWEVRYRIVKDLASALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHA 169 Query: 231 DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENL 290 T + GT GY APE +SSG + SDVYSFGV+ LEI SG+R+++ E L Sbjct: 170 KG-LKKTLLAGTVGYMAPECLSSGKASKESDVYSFGVVALEIASGRRSIEPKFEESEALL 228 Query: 291 VDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQ 350 + ++L I D +L + P++ + V + C RP++ QV++ L Sbjct: 229 LVPWVWESYGNERILDIADRKLGMAFDPKQLECLVMVGLWCAHPSHNLRPSIRQVIQVLN 288 >2PSQ-A nrPDB Length = 370 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 79/341 (23%), Positives = 136/341 (39%), Gaps = 46/341 (13%) Query: 27 LSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWL 86 LSS + +A + E L P F ++L L +GEG FG V Sbjct: 53 LSSTADTPMLAGVSEYE---LPEDPKWEFPRDKLTL-------GKPLGEGCFGQVVMA-- 100 Query: 87 DESTLTPTKPGTGLVIAVKKLNQEGFQGH-REWLTEINYLGQL-SHPNLVKLIGYCLEDE 144 + + KP + +AVK L + + + ++E+ + + H N++ L+G C +D Sbjct: 101 EAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG 160 Query: 145 HRLLVYEFMQKGSLENHLFRRGAYF------------KPLPWFLRVNVALDAAKGLAFLH 192 ++ E+ KG+L +L R + + + V+ A+G+ +L Sbjct: 161 PLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA 220 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMS 252 S K I+RD+ A N+L+ + K++DFGLARD D +T + APE + Sbjct: 221 SQ--KCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALF 278 Query: 253 SGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNR 311 +SDV+SFGVL+ EI + G ++ ++ Sbjct: 279 DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP-----------------VEELFKLLKEG 321 Query: 312 LDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 + + C P RPT Q+V L ++ Sbjct: 322 HRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 362 >5A46-A nrPDB Length = 386 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 84/383 (21%), Positives = 142/383 (37%), Gaps = 52/383 (13%) Query: 29 SRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDE 88 S + +A + E L P +L +GEG FG V + Sbjct: 14 SSSGTPMLAGVSEYE---LPEDP-------RWELPRDRLVLGKPLGEGCFGQVVLA--EA 61 Query: 89 STLTPTKPGTGLVIAVKKLNQEGFQGH-REWLTEINYLGQL-SHPNLVKLIGYCLEDEHR 146 L KP +AVK L + + + ++E+ + + H N++ L+G C +D Sbjct: 62 IGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPL 121 Query: 147 LLVYEFMQKGSLENHLFRRGAYF------------KPLPWFLRVNVALDAAKGLAFLHSD 194 ++ E+ KG+L +L R + L V+ A A+G+ +L S Sbjct: 122 YVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASK 181 Query: 195 PVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSG 254 K I+RD+ A N+L+ D K++DFGLARD D +T + APE + Sbjct: 182 --KCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDR 239 Query: 255 HLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLD 313 +SDV+SFGVLL EI + G ++ ++ Sbjct: 240 IYTHQSDVWSFGVLLWEIFTLGGSPYPGVP-----------------VEELFKLLKEGHR 282 Query: 314 TQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL------QDNLGKPSQTNPVKD 367 + + C P RPT Q+V L ++ Q+ L + Sbjct: 283 MDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSP 342 Query: 368 TKKLGFKTGTTKSSEKRFTQKPF 390 + + + + F+ +P Sbjct: 343 SFPDTRSSTCSSGEDSVFSHEPL 365 >6GQK-A nrPDB Length = 328 Score = 255 bits (650), Expect = 4e-68, Method: Composition-based stats. Identities = 80/316 (25%), Positives = 123/316 (38%), Gaps = 36/316 (11%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 ++ + +G G FG V + + K + +AVK L RE Sbjct: 34 HKWEFPRNRLSFGKTLGAGAFGKVVEA----TAQGLIKSDAAMTVAVKMLKPSAHSTERE 89 Query: 118 WLT-EINYLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKP---- 171 L E+ L L +H N+V L+G C L++ E+ G L N L R+ F P Sbjct: 90 ALMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVA 149 Query: 172 --------LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGL 223 L ++ + AKG+AFL S I+RD+ A NILL K+ DFGL Sbjct: 150 PEDLYKDFLTLEHLLSFSYQVAKGMAFLASK--NCIHRDLAARNILLTHGNITKICDFGL 207 Query: 224 ARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNR 283 ARD + APE + + SDV+S+G+ L E+ S + Sbjct: 208 ARDIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGM 267 Query: 284 PAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMD 343 P + + S +Y P E M + C +P RPT Sbjct: 268 PVDSKFYKMIKEGFRMS------------SPEYAPAE---MYDIMKTCWDADPDKRPTFK 312 Query: 344 QVVRALQ-QLQDNLGK 358 Q+V+ ++ Q+ ++ Sbjct: 313 QIVQDIEKQISESTNH 328 >1AD5-A nrPDB Length = 438 Score = 254 bits (648), Expect = 5e-68, Method: Composition-based stats. Identities = 81/327 (24%), Positives = 137/327 (41%), Gaps = 45/327 (13%) Query: 39 AQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGT 98 QK +SS P K + + ++ + + + +G G FG V+ ++ T Sbjct: 156 CQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT-------- 207 Query: 99 GLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSL 158 +AVK + G +L E N + L H LVKL + E ++ EFM KGSL Sbjct: 208 --KVAVKTMKP-GSMSVEAFLAEANVMKTLQHDKLVKLHAV-VTKEPIYIITEFMAKGSL 263 Query: 159 ENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKL 218 + L +PLP ++ + A+G+AF+ I+RD++A+NIL+ A K+ Sbjct: 264 LDFLKSDEGSKQPLPK--LIDFSAQIAEGMAFIEQR--NYIHRDLRAANILVSASLVCKI 319 Query: 219 SDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKR 277 +DFGLAR + APE ++ G +SDV+SFG+LL+EI++ G+ Sbjct: 320 ADFGLAR-----------VGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRI 368 Query: 278 ALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPK 337 S +V+ ++ + ++ ++C P+ Sbjct: 369 PYPG-----------------MSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPE 411 Query: 338 SRPTMDQVVRALQQLQDNLGKPSQTNP 364 RPT + + L Q P Sbjct: 412 ERPTFEYIQSVLDDFYTATESQYQQQP 438 >4AT3-A nrPDB Length = 299 Score = 254 bits (648), Expect = 6e-68, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 116/307 (37%), Gaps = 33/307 (10%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 + N +GEG FG VF K +++AVK L +++ Sbjct: 9 HIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDK----ILVAVKTLKDASDNARKDFHR 64 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF---------KP 171 E L L H ++VK G C+E + ++V+E+M+ G L L G Sbjct: 65 EAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTE 124 Query: 172 LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGD 231 L +++A A G+ +L S ++RD+ N L+ + K+ DFG++RD D Sbjct: 125 LTQSQMLHIAQQIAAGMVYLASQ--HFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTD 182 Query: 232 LSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENL 290 V M + PE + SDV+S GV+L EI + GK+ Sbjct: 183 YYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPW----------- 231 Query: 291 VDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQ 350 Y S +V+ + Q + + + C EP R + + LQ Sbjct: 232 ------YQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQ 285 Query: 351 QLQDNLG 357 L Sbjct: 286 NLAKASP 292 >1JPA-A nrPDB Length = 312 Score = 254 bits (648), Expect = 6e-68, Method: Composition-based stats. Identities = 76/330 (23%), Positives = 139/330 (42%), Gaps = 42/330 (12%) Query: 52 VKSFTFNELKLATRNF---------RPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVI 102 + FTF + A R F + + VIG G FG V G L + + Sbjct: 11 IDPFTFEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKRE------IFV 64 Query: 103 AVKKLNQ-EGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENH 161 A+K L + R++L+E + +GQ HPN++ L G + +++ EFM+ GSL++ Sbjct: 65 AIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSF 124 Query: 162 LFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDF 221 L + F + V + A G+ +L + ++RD+ A NIL++++ K+SDF Sbjct: 125 LRQNDGQFTVI---QLVGMLRGIAAGMKYL--ADMNYVHRDLAARNILVNSNLVCKVSDF 179 Query: 222 GLARDGPMGDLSYVSTRVMG---TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKR 277 GL+R T +G + APE + + SDV+S+G+++ E++S G+R Sbjct: 180 GLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGER 239 Query: 278 ALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPK 337 + + V+ ++ + + + + C + Sbjct: 240 PYWD-----------------MTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRN 282 Query: 338 SRPTMDQVVRALQQLQDNLGKPSQTNPVKD 367 RP Q+V L ++ N P+ Sbjct: 283 HRPKFGQIVNTLDKMIRNPNSLKAMAPLSS 312 >5JN2-A nrPDB Length = 525 Score = 253 bits (647), Expect = 8e-68, Method: Composition-based stats. Identities = 72/338 (21%), Positives = 133/338 (39%), Gaps = 40/338 (11%) Query: 17 GKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEG 76 G+ G + +S A G+ L +TP F + + + ++ V+G+G Sbjct: 20 GQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPG-MFVQHSTAIFSDRYKGQRVLGKG 78 Query: 77 GFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ---GHREWLTEINYLGQLSHPNL 133 FG V TG AVK +++ + L E+ L QL HPN+ Sbjct: 79 SFGEVILC---------KDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNI 129 Query: 134 VKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHS 193 +KL + + + LV E G L + + R + + + G+ ++H Sbjct: 130 MKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSE----VDAARIIRQVLSGITYMHK 185 Query: 194 DPVKVIYRDIKASNILLDA---DYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEY 250 + K+++RD+K N+LL++ D N ++ DFGL+ + S +GT Y APE Sbjct: 186 N--KIVHRDLKPENLLLESKSKDANIRIIDFGLSTHF---EASKKMKDKIGTAYYIAPEV 240 Query: 251 MSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDN 310 + G + + DV+S GV+L +LSG + V+ + Sbjct: 241 LH-GTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTF------------ 287 Query: 311 RLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + + + + L++ P R + + Sbjct: 288 --ELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDH 323 >3GQL-A nrPDB Length = 326 Score = 253 bits (647), Expect = 8e-68, Method: Composition-based stats. Identities = 75/308 (24%), Positives = 122/308 (39%), Gaps = 36/308 (11%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-REW 118 +L +GEG FG V + L KP +AVK L + + + Sbjct: 23 WELPRDRLVLGKPLGEGAFGQVVLA--EAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDL 80 Query: 119 LTEINYLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF-------- 169 ++E+ + + H N++ L+G C +D ++ E+ KG+L +L R Sbjct: 81 ISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPS 140 Query: 170 ----KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR 225 + L V+ A A+G+ +L S K I+RD+ A N+L+ D K++DFGLAR Sbjct: 141 HNPEEQLSSKDLVSCAYQVARGMEYLASK--KCIHRDLAARNVLVTEDNVMKIADFGLAR 198 Query: 226 DGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRP 284 D D +T + APE + +SDV+SFGVLL EI + G Sbjct: 199 DIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVP- 257 Query: 285 AKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQ 344 ++ ++ + + C P RPT Q Sbjct: 258 ----------------VEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQ 301 Query: 345 VVRALQQL 352 +V L ++ Sbjct: 302 LVEDLDRI 309 >3V5Q-A nrPDB Length = 297 Score = 253 bits (646), Expect = 9e-68, Method: Composition-based stats. Identities = 72/310 (23%), Positives = 122/310 (39%), Gaps = 36/310 (11%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 + R+ +GEG FG VF + T K +++AVK L +++ Sbjct: 11 HIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDK----MLVAVKALKDPTLAARKDFQR 66 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFK---------- 170 E L L H ++VK G C + + ++V+E+M+ G L L G Sbjct: 67 EAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQA 126 Query: 171 --PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGP 228 L +++A A G+ +L S ++RD+ N L+ A+ K+ DFG++RD Sbjct: 127 KGELGLSQMLHIASQIASGMVYLASQ--HFVHRDLATRNCLVGANLLVKIGDFGMSRDVY 184 Query: 229 MGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKE 287 D V M + PE + SDV+SFGV+L EI + GK+ Sbjct: 185 STDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPW-------- 236 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 + S +V+ + + + V + C EP+ R + ++ + Sbjct: 237 ---------FQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYK 287 Query: 348 ALQQLQDNLG 357 L L Sbjct: 288 ILHALGKATP 297 >6DBM-A nrPDB Length = 318 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 90/322 (27%), Positives = 142/322 (44%), Gaps = 23/322 (7%) Query: 45 EILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAV 104 E+L P F++ R + +GEG FG V D PT GTG ++AV Sbjct: 16 EVLFQGPGDPTVFHK-----RYLKKIRDLGEGHFGKVSLYCYD-----PTNDGTGEMVAV 65 Query: 105 KKLNQEGFQGHRE-WLTEINYLGQLSHPNLVKLIGYCLEDE--HRLLVYEFMQKGSLENH 161 K L + HR W EI+ L L H +++K G C + LV E++ GSL ++ Sbjct: 66 KALKADAGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDY 125 Query: 162 LFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDF 221 L R + + A +G+A+LHS I+RD+ A N+LLD D K+ DF Sbjct: 126 LPRHS-----IGLAQLLLFAQQICEGMAYLHSQ--HYIHRDLAARNVLLDNDRLVKIGDF 178 Query: 222 GLARDGPMGDLSY-VSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 GLA+ P G Y V + APE + SDV+SFGV L E+L+ + Sbjct: 179 GLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDS-S 237 Query: 281 HNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP 340 + P K L+ A+ +T R + +++ + + + C E RP Sbjct: 238 QSPPTKFLELIGIAQGQMTVLR-LTELLERGERLPRPDKCPAEVYHLMKNCWETEASFRP 296 Query: 341 TMDQVVRALQQLQDNLGKPSQT 362 T + ++ L+ + + + + Sbjct: 297 TFENLIPILKTVHEKYQGQAPS 318 >2OGV-A nrPDB Length = 317 Score = 252 bits (643), Expect = 2e-67, Method: Composition-based stats. Identities = 86/325 (26%), Positives = 130/325 (40%), Gaps = 40/325 (12%) Query: 45 EILSSTPVKSFTF---------NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTK 95 +I+ S S+TF + + N + +G G FG V + + K Sbjct: 9 KIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEA----TAFGLGK 64 Query: 96 PGTGLVIAVKKLNQEGFQGHREWLT-EINYLGQL-SHPNLVKLIGYCLEDEHRLLVYEFM 153 L +AVK L +E L E+ + L H N+V L+G C L++ E+ Sbjct: 65 EDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYC 124 Query: 154 QKGSLENHLFRR------GAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASN 207 G L N L R+ +PL ++ + A+G+AFL S I+RD+ A N Sbjct: 125 CYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASK--NCIHRDVAARN 182 Query: 208 ILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGV 267 +LL + AK+ DFGLARD V + APE + +SDV+S+G+ Sbjct: 183 VLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGI 242 Query: 268 LLLEILS-GKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMAS 326 LL EI S G P + K +V + + S Sbjct: 243 LLWEIFSLGLNPY----------------PGILVNSKFYKLVKDGYQMAQPAFAPKNIYS 286 Query: 327 VAVQCLSFEPKSRPTMDQVVRALQQ 351 + C + EP RPT Q+ LQ+ Sbjct: 287 IMQACWALEPTHRPTFQQICSFLQE 311 >2PL0-A nrPDB Length = 289 Score = 251 bits (641), Expect = 3e-67, Method: Composition-based stats. Identities = 81/318 (25%), Positives = 137/318 (43%), Gaps = 35/318 (11%) Query: 48 SSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL 107 + P K + +E ++ + +G G FG V+ G+ + T +AVK L Sbjct: 6 TQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHT----------KVAVKSL 55 Query: 108 NQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGA 167 ++G +L E N + QL H LV+L + E ++ E+M+ GSL + L + Sbjct: 56 -KQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQ-EPIYIITEYMENGSLVDFL--KTP 111 Query: 168 YFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG 227 L +++A A+G+AF+ I+RD++A+NIL+ + K++DFGLAR Sbjct: 112 SGIKLTINKLLDMAAQIAEGMAFIEER--NYIHRDLRAANILVSDTLSCKIADFGLARLI 169 Query: 228 PMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAK 286 + + + APE ++ G +SDV+SFG+LL EI++ G+ Sbjct: 170 EDNEYTA-REGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPG--MTN 226 Query: 287 EENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVV 346 E + + R Y + PEE + + C P+ RPT D + Sbjct: 227 PEVIQNLERGYRM------------VRPDNCPEE---LYQLMRLCWKERPEDRPTFDYLR 271 Query: 347 RALQQLQDNLGKPSQTNP 364 L+ Q P Sbjct: 272 SVLEDFFTATEGQYQPQP 289 >3BEA-A nrPDB Length = 333 Score = 251 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 86/329 (26%), Positives = 130/329 (39%), Gaps = 44/329 (13%) Query: 45 EILSSTPVKSFTF---------NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTK 95 +I+ S S+TF + + N + +G G FG V + + K Sbjct: 17 KIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEA----TAFGLGK 72 Query: 96 PGTGLVIAVKKLNQEGFQGHREWLT-EINYLGQL-SHPNLVKLIGYCLEDEHRLLVYEFM 153 L +AVK L +E L E+ + L H N+V L+G C L++ E+ Sbjct: 73 EDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYC 132 Query: 154 QKGSLENHLFRRGAYFKPLPWFL----------RVNVALDAAKGLAFLHSDPVKVIYRDI 203 G L N L R+ + P F ++ + A+G+AFL S I+RD+ Sbjct: 133 CYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASK--NCIHRDV 190 Query: 204 KASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVY 263 A N+LL + AK+ DFGLARD V + APE + +SDV+ Sbjct: 191 AARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVW 250 Query: 264 SFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAV 322 S+G+LL EI S G P + K +V + Sbjct: 251 SYGILLWEIFSLGLNPY----------------PGILVNSKFYKLVKDGYQMAQPAFAPK 294 Query: 323 RMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 + S+ C + EP RPT Q+ LQ+ Sbjct: 295 NIYSIMQACWALEPTHRPTFQQICSFLQE 323 >5KMM-A nrPDB Length = 329 Score = 250 bits (638), Expect = 9e-67, Method: Composition-based stats. Identities = 75/309 (24%), Positives = 120/309 (38%), Gaps = 35/309 (11%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 + R+ +GEG FG VF K +++AVK L + +++ Sbjct: 31 HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDK----MLVAVKALKEASESARQDFQR 86 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFK---------- 170 E L L H ++V+ G C E L+V+E+M+ G L L G K Sbjct: 87 EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAP 146 Query: 171 -PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPM 229 PL + VA A G+ +L + ++RD+ N L+ K+ DFG++RD Sbjct: 147 GPLGLGQLLAVASQVAAGMVYL--AGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYS 204 Query: 230 GDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEE 288 D V R M + PE + SDV+SFGV+L EI + GK+ Sbjct: 205 TDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPW--------- 255 Query: 289 NLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 Y S + + + + + + ++ C EP+ R ++ V Sbjct: 256 --------YQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR 307 Query: 349 LQQLQDNLG 357 LQ L Sbjct: 308 LQALAQAPP 316 >3DKO-A nrPDB Length = 318 Score = 250 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 74/324 (22%), Positives = 134/324 (41%), Gaps = 31/324 (9%) Query: 35 TVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPT 94 + P ++ +L + + VIG G FG V G L Sbjct: 13 KFPGTKTYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDV 72 Query: 95 KPGTGLVIAVKKLNQ-EGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFM 153 +A+K L + R++L E + +GQ HPN+V L G + ++V EFM Sbjct: 73 ------AVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFM 126 Query: 154 QKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD 213 + G+L+ L + F + V + A G+ +L + ++RD+ A NIL++++ Sbjct: 127 ENGALDAFLRKHDGQFTVI---QLVGMLRGIAAGMRYL--ADMGYVHRDLAARNILVNSN 181 Query: 214 YNAKLSDFGLARDGPMG-DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEI 272 K+SDFGL+R + Y +T + APE + + SDV+S+G+++ E+ Sbjct: 182 LVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEV 241 Query: 273 LS-GKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQC 331 +S G+R S + V+ ++ + + + + C Sbjct: 242 MSYGERPYWD-----------------MSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDC 284 Query: 332 LSFEPKSRPTMDQVVRALQQLQDN 355 E RP +Q+V L ++ N Sbjct: 285 WQKERAERPKFEQIVGILDKMIRN 308 >5AMN-A nrPDB Length = 299 Score = 250 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 75/302 (24%), Positives = 129/302 (42%), Gaps = 31/302 (10%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-RE 117 + + +N +GEG FG V K + +AVK L + R+ Sbjct: 17 KWEFPRKNLVLGKTLGEGEFGKVVKA----TAFHLKGRAGYTTVAVKMLKENASPSELRD 72 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGA------YFKP 171 L+E N L Q++HP+++KL G C +D LL+ E+ + GSL L + Sbjct: 73 LLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERA 132 Query: 172 LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGD 231 L ++ A ++G+ +L +K+++RD+ A NIL+ K+SDFGL+RD D Sbjct: 133 LTMGDLISFAWQISQGMQYLAE--MKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED 190 Query: 232 LSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENL 290 ++ + A E + +SDV+SFGVLL EI++ G P Sbjct: 191 SYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP------ 244 Query: 291 VDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQ 350 ++ ++ + + M + +QC EP RP + + L+ Sbjct: 245 -----------ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLE 293 Query: 351 QL 352 ++ Sbjct: 294 KM 295 >3KRL-A nrPDB Length = 335 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 85/331 (25%), Positives = 129/331 (38%), Gaps = 46/331 (13%) Query: 45 EILSSTPVKSFTF---------NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTK 95 +I+ S S+TF + + N + +G G FG V + + K Sbjct: 17 KIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEA----TAFGLGK 72 Query: 96 PGTGLVIAVKKLNQEGFQGHREWLT-EINYLGQL-SHPNLVKLIGYCLEDEHRLLVYEFM 153 L +AVK L +E L E+ + L H N+V L+G C L++ E+ Sbjct: 73 EDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYC 132 Query: 154 QKGSLENHLFRRGAYF------------KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYR 201 G L N L R+ + L ++ + A+G+AFL S I+R Sbjct: 133 CYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASK--NCIHR 190 Query: 202 DIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSD 261 D+ A N+LL + AK+ DFGLARD V + APE + +SD Sbjct: 191 DVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSD 250 Query: 262 VYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEE 320 V+S+G+LL EI S G P + K +V + Sbjct: 251 VWSYGILLWEIFSLGLNPY----------------PGILVNSKFYKLVKDGYQMAQPAFA 294 Query: 321 AVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 + S+ C + EP RPT Q+ LQ+ Sbjct: 295 PKNIYSIMQACWALEPTHRPTFQQICSFLQE 325 >4GS6-A nrPDB Length = 315 Score = 249 bits (636), Expect = 2e-66, Method: Composition-based stats. Identities = 82/337 (24%), Positives = 145/337 (43%), Gaps = 46/337 (13%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 + + + V+G G FG V K +A+K++ E + ++ Sbjct: 5 MIDYKEIEVEEVVGRGAFGVVCKAKWRAKD-----------VAIKQI--ESESERKAFIV 51 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN- 179 E+ L +++HPN+VKL G CL LV E+ + GSL N L +PLP++ + Sbjct: 52 ELRQLSRVNHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVLH----GAEPLPYYTAAHA 105 Query: 180 --VALDAAKGLAFLHSDPVK-VIYRDIKASNILLDADYNA-KLSDFGLARDGPMGDLSYV 235 L ++G+A+LHS K +I+RD+K N+LL A K+ DFG A D+ Sbjct: 106 MSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-----DIQTH 160 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 T G+ + APE + + + DV+S+G++L E+++ ++ D Sbjct: 161 MTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAF-------- 212 Query: 296 PYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 +++ V N + + S+ +C S +P RP+M+++V+ + L Sbjct: 213 -------RIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRY 265 Query: 356 LGKPSQTNPVKDTKKLGFKTGTTKSSEKRFTQKPFGR 392 P P++ + G E F R Sbjct: 266 F--PGADEPLQYPCQHSLPPGEDGRVEPYVDFAEFYR 300 >4OLI-A nrPDB Length = 645 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 84/300 (28%), Positives = 136/300 (45%), Gaps = 18/300 (6%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYL 125 + +GEG FG V D PT GTG ++AVK L + HR W EI+ L Sbjct: 355 LKKIRDLGEGHFGKVSLYCYD-----PTNDGTGEMVAVKALKADCGPQHRSGWKQEIDIL 409 Query: 126 GQLSHPNLVKLIGYCLE--DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 L H +++K G C + ++ LV E++ GSL ++L R + + A Sbjct: 410 RTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS-----IGLAQLLLFAQQ 464 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSY-VSTRVMGT 242 +G+A+LHS I+R++ A N+LLD D K+ DFGLA+ P G Y V Sbjct: 465 ICEGMAYLHSQ--HYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSP 522 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 + APE + SDV+SFGV L E+L+ + + P K L+ A+ +T R Sbjct: 523 VFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDS-SQSPPTKFLELIGIAQGQMTVLR 581 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQT 362 + +++ + + + C E RPT + ++ L+ + + + + Sbjct: 582 -LTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPS 640 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 73/324 (22%), Positives = 131/324 (40%), Gaps = 56/324 (17%) Query: 73 IGEGGFGCVFKGWL---------------DESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 +G+G V++G L ++ + G L + +K L+ Sbjct: 53 LGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALA 112 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 + + + Q+SH +L + G C+ ++V E+++ G L+ L R + P+ W + Sbjct: 113 FYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHV-PMAW--K 169 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN-------AKLSDFGLARDGPMG 230 + VA A L++L + +++ ++ NILL KLSD G+ G Sbjct: 170 MVVAQQLASALSYLENK--NLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGV------G 221 Query: 231 DLSYVSTRVMGTYGYAAPEYMSSG--HLNARSDVYSFGVLLLEI-LSGKRALDHNRPAKE 287 + + + APE + G L+ D + FG LLEI G+ L P+++ Sbjct: 222 LGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEK 281 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 E+ +RL P ++A++ QCL++EP RP+ ++R Sbjct: 282 EHF---------------YQRQHRLPEPSCP----QLATLTSQCLTYEPTQRPSFRTILR 322 Query: 348 ALQQLQ-DNLGKPSQTNPVKDTKK 370 L +LQ NL NP Sbjct: 323 DLTRLQPHNLADVLTVNPDSPASD 346 >4XEY-B nrPDB Length = 408 Score = 248 bits (634), Expect = 3e-66, Method: Composition-based stats. Identities = 67/330 (20%), Positives = 141/330 (42%), Gaps = 37/330 (11%) Query: 35 TVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPT 94 A ++ + + +P +++ ++ + +G G +G V++G + +LT Sbjct: 99 HYPAPKRNKPTVYGVSP----NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLT-- 152 Query: 95 KPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQ 154 +AVK L ++ + E+L E + ++ HPNLV+L+G C + ++ EFM Sbjct: 153 -------VAVKTLKEDTME-VEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMT 204 Query: 155 KGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY 214 G+L ++L R + + + + +A + + +L I+RD+ A N L+ ++ Sbjct: 205 YGNLLDYL--RECNRQEVNAVVLLYMATQISSAMEYLEKK--NFIHRDLAARNCLVGENH 260 Query: 215 NAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 K++DFGL+R GD + APE ++ + +SDV++FGVLL EI + Sbjct: 261 LVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIAT 319 Query: 275 -GKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLS 333 G + +V +++ + ++ + C Sbjct: 320 YGMSPYPGIDLS-----------------QVYELLEKDYRMERPEGCPEKVYELMRACWQ 362 Query: 334 FEPKSRPTMDQVVRALQQLQDNLGKPSQTN 363 + P RP+ ++ +A + + + Sbjct: 363 WNPSDRPSFAEIHQAFETMFQESSISDEVE 392 >4K33-A nrPDB Length = 325 Score = 248 bits (634), Expect = 3e-66, Method: Composition-based stats. Identities = 71/309 (22%), Positives = 123/309 (39%), Gaps = 36/309 (11%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-RE 117 + +L+ +GEG FG V + + + + +AVK L + + Sbjct: 30 KWELSRARLTLGKPLGEGAFGQVVMA--EAIGIDKDRAAKPVTVAVKMLKDDATDKDLSD 87 Query: 118 WLTEINYLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF------- 169 ++E+ + + H N++ L+G C + ++ E+ KG+L L R Sbjct: 88 LVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDT 147 Query: 170 -----KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLA 224 + L + V+ A A+G+ +L S K I+RD+ A N+L+ D K++DFGLA Sbjct: 148 SKPPEEQLTFKDLVSCAYQVARGMEYLASQ--KCIHRDLAARNVLVTEDNVMKIADFGLA 205 Query: 225 RDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNR 283 RD D +T + APE + +SDV+SFGVLL EI + G Sbjct: 206 RDVHNLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIP 265 Query: 284 PAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMD 343 ++ ++ + + +C P RPT Sbjct: 266 -----------------VEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFK 308 Query: 344 QVVRALQQL 352 Q+V L ++ Sbjct: 309 QLVEDLDRV 317 >2H8H-A nrPDB Length = 535 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 81/316 (25%), Positives = 137/316 (43%), Gaps = 36/316 (11%) Query: 48 SSTPV-KSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKK 106 +S P + + ++ + R + +G+G FG V+ G + +T +A+K Sbjct: 249 TSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----------VAIKT 298 Query: 107 LNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRG 166 L G +L E + +L H LV+L E E +V E+M KGSL + L +G Sbjct: 299 LKP-GTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFL--KG 354 Query: 167 AYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD 226 K L V++A A G+A++ + + ++RD++A+NIL+ + K++DFGLAR Sbjct: 355 ETGKYLRLPQLVDMAAQIASGMAYV--ERMNYVHRDLRAANILVGENLVCKVADFGLARL 412 Query: 227 GPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPA 285 + + + APE G +SDV+SFG+LL E+ + G+ Sbjct: 413 IEDNEYTARQ-GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPG---- 467 Query: 286 KEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQV 345 R+VL V+ PE + + QC EP+ RPT + + Sbjct: 468 -------------MVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYL 514 Query: 346 VRALQQLQDNLGKPSQ 361 L+ + Q Sbjct: 515 QAFLEDYFTSTEPQYQ 530 >6FER-A nrPDB Length = 309 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 65/305 (21%), Positives = 133/305 (43%), Gaps = 24/305 (7%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKP-------GTGLVIAVKKLNQEGFQ 113 + + +GEG FG V ++ K +++AVK L + + Sbjct: 5 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK 64 Query: 114 GHR-EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRG------ 166 R ++L EI + +L PN++ L+ C+ D+ ++ E+M+ G L L R Sbjct: 65 NARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSS 124 Query: 167 AYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD 226 + + + + +A A G+ +L S + ++RD+ N L+ +Y K++DFG++R+ Sbjct: 125 SDVRTVSYTNLKFMATQIASGMKYLSS--LNFVHRDLATRNCLVGKNYTIKIADFGMSRN 182 Query: 227 GPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK 286 GD + R + + + E + G SDV++FGV L E + + +++ + Sbjct: 183 LYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSD 242 Query: 287 EENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVV 346 E+ + + + R+ L P+ + + + C + K+RP+ ++ Sbjct: 243 EQVIENTGEFFRDQGRQTYL-----PQPAICPD---SVYKLMLSCWRRDTKNRPSFQEIH 294 Query: 347 RALQQ 351 L Q Sbjct: 295 LLLLQ 299 >2FO0-A nrPDB Length = 495 Score = 247 bits (631), Expect = 6e-66, Method: Composition-based stats. Identities = 66/330 (20%), Positives = 141/330 (42%), Gaps = 37/330 (11%) Query: 35 TVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPT 94 A ++ + + +P +++ ++ + +G G +G V++G + +LT Sbjct: 191 HYPAPKRNKPTVYGVSP----NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLT-- 244 Query: 95 KPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQ 154 +AVK L ++ + E+L E + ++ HPNLV+L+G C + ++ EFM Sbjct: 245 -------VAVKTLKEDTME-VEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMT 296 Query: 155 KGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY 214 G+L ++L R + + + + +A + + +L I+R++ A N L+ ++ Sbjct: 297 YGNLLDYL--RECNRQEVNAVVLLYMATQISSAMEYLEKK--NFIHRNLAARNCLVGENH 352 Query: 215 NAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS 274 K++DFGL+R GD + APE ++ + +SDV++FGVLL EI + Sbjct: 353 LVKVADFGLSRLMT-GDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIAT 411 Query: 275 -GKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLS 333 G + +V +++ + ++ + C Sbjct: 412 YGMSPYPGIDLS-----------------QVYELLEKDYRMERPEGCPEKVYELMRACWQ 454 Query: 334 FEPKSRPTMDQVVRALQQLQDNLGKPSQTN 363 + P RP+ ++ +A + + + Sbjct: 455 WNPSDRPSFAEIHQAFETMFQESSISDEVE 484 >2R2P-A nrPDB Length = 295 Score = 247 bits (631), Expect = 6e-66, Method: Composition-based stats. Identities = 73/300 (24%), Positives = 133/300 (44%), Gaps = 31/300 (10%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ-EGFQGHREWL 119 ++ + VIG G FG V G L L +A+K L + R++L Sbjct: 18 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRE------LPVAIKTLKVGYTEKQRRDFL 71 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 E + +GQ HPN++ L G + + ++V E+M+ GSL+ L + F + V Sbjct: 72 GEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVI---QLVG 128 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR- 238 + + G+ +L + ++RD+ A NIL++++ K+SDFGL+R + +TR Sbjct: 129 MLRGISAGMKYL--SDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG 186 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPY 297 + APE ++ + SDV+S+G+++ E++S G+R Sbjct: 187 GKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWE---------------- 230 Query: 298 LTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLG 357 + + V+ V+ + + + + C E SRP D++V L +L N Sbjct: 231 -MTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPA 289 >5MJB-A nrPDB Length = 305 Score = 247 bits (630), Expect = 6e-66, Method: Composition-based stats. Identities = 68/296 (22%), Positives = 132/296 (44%), Gaps = 33/296 (11%) Query: 68 RPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ-EGFQGHREWLTEINYLG 126 + + VIG G FG V+KG L + +A+K L + R++L+E + +G Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKRE------IYVAIKTLKAGYSEKQRRDFLSEASIMG 82 Query: 127 QLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAK 186 Q H N+++L G + +++ EFM+ +L++ L + F + V + A Sbjct: 83 QFDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVI---QLVGMLRGIAA 139 Query: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG---TY 243 G+ +L + ++RD+ A NIL++++ K+SDFGL+R T +G Sbjct: 140 GMKYL--SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPV 197 Query: 244 GYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLTSKR 302 + APE ++ + SDV+S+G+++ E++S G+R S + Sbjct: 198 RWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWD-----------------MSNQ 240 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGK 358 V+ ++ + + + + C + SRP ++V L ++ N Sbjct: 241 DVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPAS 296 >3COM-A nrPDB Length = 314 Score = 247 bits (630), Expect = 7e-66, Method: Composition-based stats. Identities = 80/288 (27%), Positives = 129/288 (44%), Gaps = 33/288 (11%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 K F +GEG +G V+K E TG ++A+K++ E +E + Sbjct: 25 KQPEEVFDVLEKLGEGSYGSVYKAIHKE---------TGQIVAIKQVPVES--DLQEIIK 73 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 EI+ + Q P++VK G ++ +V E+ GS+ + + R K L + Sbjct: 74 EISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRN---KTLTEDEIATI 130 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 KGL +LH ++ I+RDIKA NILL+ + +AKL+DFG+A G + D V+ Sbjct: 131 LQSTLKGLEYLH--FMRKIHRDIKAGNILLNTEGHAKLADFGVA--GQLTDTMAKRNTVI 186 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 GT + APE + N +D++S G+ +E+ GK P + ++ P + Sbjct: 187 GTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPP--T 244 Query: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 RK L DN QCL P+ R T Q+++ Sbjct: 245 FRKPELWSDN-------------FTDFVKQCLVKSPEQRATATQLLQH 279 >6NPU-A nrPDB Length = 298 Score = 247 bits (630), Expect = 8e-66, Method: Composition-based stats. Identities = 65/308 (21%), Positives = 134/308 (43%), Gaps = 33/308 (10%) Query: 57 FNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR 116 +++ ++ + +G G +G V++G + +LT +AVK L ++ + Sbjct: 18 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLT---------VAVKTLKEDTME-VE 67 Query: 117 EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 E+L E + ++ HPNLV+L+G C + ++ EFM G+L ++L R + + + Sbjct: 68 EFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYL--RECNRQEVNAVV 125 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 + +A + + +L I+RD+ A N L+ ++ K++DFGL+R GD Sbjct: 126 LLYMATQISSAMEYLEKK--NFIHRDLAARNCLVGENHLVKVADFGLSRLMT-GDTYTAH 182 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWAR 295 + APE ++ + +SDV++FGVLL EI + G + Sbjct: 183 AGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS---------- 232 Query: 296 PYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 +V +++ + ++ + C + P RP+ ++ +A + + Sbjct: 233 -------QVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQE 285 Query: 356 LGKPSQTN 363 + Sbjct: 286 SSISDEVE 293 >3A4O-X nrPDB Length = 286 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 73/313 (23%), Positives = 127/313 (40%), Gaps = 34/313 (10%) Query: 53 KSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF 112 K + + ++ + + +G G FG V+ G+ + ST +AVK L G Sbjct: 1 KPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNST----------KVAVKTLKP-GT 49 Query: 113 QGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPL 172 + +L E N + L H LV+L +E ++ E+M KGSL + L L Sbjct: 50 MSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLL 109 Query: 173 PWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDL 232 P ++ + A+G+A++ I+RD++A+N+L+ K++DFGLAR + Sbjct: 110 PK--LIDFSAQIAEGMAYIERK--NYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEY 165 Query: 233 SYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLV 291 + + APE ++ G +SDV+SFG+LL EI++ GK Sbjct: 166 TA-REGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPG---------- 214 Query: 292 DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 + V+ + + + + C + + RPT D + L Sbjct: 215 -------RTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDD 267 Query: 352 LQDNLGKPSQTNP 364 Q P Sbjct: 268 FYTATEGQYQQQP 280 >1LUF-A nrPDB Length = 343 Score = 246 bits (629), Expect = 9e-66, Method: Composition-based stats. Identities = 74/316 (23%), Positives = 127/316 (40%), Gaps = 45/316 (14%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWL 119 + N IGEG FG VF+ L P +P T ++AVK L +E + ++ Sbjct: 43 EYPRNNIEYVRDIGEGAFGRVFQAR--APGLLPYEPFT--MVAVKMLKEEASADMQADFQ 98 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF---------- 169 E + + +PN+VKL+G C + L++E+M G L L + Sbjct: 99 REAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLS 158 Query: 170 ----------KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLS 219 PL ++ +A A G+A+L K ++RD+ N L+ + K++ Sbjct: 159 TRARVSSPGPPPLSCAEQLCIARQVAAGMAYL--SERKFVHRDLATRNCLVGENMVVKIA 216 Query: 220 DFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRA 278 DFGL+R+ D + PE + SDV+++GV+L EI S G + Sbjct: 217 DFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQP 276 Query: 279 LDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKS 338 Y + +V+ V + + + ++ C S P Sbjct: 277 Y-----------------YGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPAD 319 Query: 339 RPTMDQVVRALQQLQD 354 RP+ + R LQ++ + Sbjct: 320 RPSFCSIHRILQRMCE 335 >6F3F-A nrPDB Length = 455 Score = 246 bits (629), Expect = 1e-65, Method: Composition-based stats. Identities = 80/316 (25%), Positives = 137/316 (43%), Gaps = 36/316 (11%) Query: 48 SSTPV-KSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKK 106 +S P + + ++ + R + +G+G FG V+ G + +T +A+K Sbjct: 169 TSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----------VAIKT 218 Query: 107 LNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRG 166 L G +L E + +L H LV+L E E +V E+M KGSL + L +G Sbjct: 219 LKP-GTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMNKGSLLDFL--KG 274 Query: 167 AYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD 226 K L V+++ A G+A++ + + ++RD++A+NIL+ + K++DFGLAR Sbjct: 275 ETGKYLRLPQLVDMSAQIASGMAYV--ERMNYVHRDLRAANILVGENLVCKVADFGLARL 332 Query: 227 GPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPA 285 + + + APE G +SDV+SFG+LL E+ + G+ Sbjct: 333 IEDNEYTARQ-GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPG---- 387 Query: 286 KEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQV 345 R+VL V+ PE + + QC EP+ RPT + + Sbjct: 388 -------------MVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYL 434 Query: 346 VRALQQLQDNLGKPSQ 361 L+ + Q Sbjct: 435 QAFLEDYFTSTEPQYQ 450 >4XLV-A nrPDB Length = 328 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 74/326 (22%), Positives = 138/326 (42%), Gaps = 29/326 (8%) Query: 33 SSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLT 92 A++ P + +E +++ +G+G FG V++G + Sbjct: 7 GPLFASSNPEYLSASDVFPSSVYVPDEWEVSREKITLLRELGQGSFGMVYEG----NARD 62 Query: 93 PTKPGTGLVIAVKKLNQEGFQGHR-EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYE 151 K +AVK +N+ R E+L E + + + ++V+L+G + + L+V E Sbjct: 63 IIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVME 122 Query: 152 FMQKGSLENHLFRRGAYFK------PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKA 205 M G L+++L + P + +A + A G+A+L + K ++RD+ A Sbjct: 123 LMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYL--NAKKFVHRDLAA 180 Query: 206 SNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSF 265 N ++ D+ K+ DFG+ RD D + + + APE + G SD++SF Sbjct: 181 RNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSF 240 Query: 266 GVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMA 325 GV+L EI S L + L++++ + ++D Q R+ Sbjct: 241 GVVLWEITS---------------LAEQPYQGLSNEQVLKFVMDGGYLDQ-PDNCPERVT 284 Query: 326 SVAVQCLSFEPKSRPTMDQVVRALQQ 351 + C F P RPT ++V L+ Sbjct: 285 DLMRMCWQFNPNMRPTFLEIVNLLKD 310 >5EG3-A nrPDB Length = 334 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 68/309 (22%), Positives = 122/309 (39%), Gaps = 36/309 (11%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-RE 117 + + +GEG FG V + + KP + +AVK L + + + Sbjct: 29 KWEFPRDKLTLGKPLGEGAFGQVVMA--EAVGIDKDKPKEAVTVAVKMLKDDATEKDLSD 86 Query: 118 WLTEINYLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF------- 169 ++E+ + + H N++ L+G C +D ++ + KG+L +L R Sbjct: 87 LVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDI 146 Query: 170 -----KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLA 224 + + + V+ A+G+ +L S K I+RD+ A N+L+ + K++DFGLA Sbjct: 147 NRVPEEQMTFKDLVSCTYQLARGMEYLASQ--KCIHRDLAARNVLVTENNVMKIADFGLA 204 Query: 225 RDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNR 283 RD D +T + APE + +SDV+SFGVL+ EI + G Sbjct: 205 RDINNIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP 264 Query: 284 PAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMD 343 ++ ++ + + C P RPT Sbjct: 265 -----------------VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFK 307 Query: 344 QVVRALQQL 352 Q+V L ++ Sbjct: 308 QLVEDLDRI 316 >2Y6O-A nrPDB Length = 291 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 69/298 (23%), Positives = 133/298 (44%), Gaps = 31/298 (10%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ-EGFQGHREWL 119 ++ + + VIG G FG V G L + +A+K L + R++L Sbjct: 10 EIDASCIKIEKVIGVGEFGEVCSGRLKVPGKRE------ICVAIKTLKAGYTDKQRRDFL 63 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 +E + +GQ HPN++ L G + + +++ E+M+ GSL+ L + F + V Sbjct: 64 SEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVI---QLVG 120 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR- 238 + G+ +L + ++RD+ A NIL++++ K+SDFG++R + +TR Sbjct: 121 MLRGIGSGMKYL--SDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRG 178 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPY 297 + APE ++ + SDV+S+G+++ E++S G+R Sbjct: 179 GKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWD---------------- 222 Query: 298 LTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 S + V+ ++ + + + + + C E RP Q+V L +L N Sbjct: 223 -MSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRN 279 >5HVK-A nrPDB Length = 315 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 81/321 (25%), Positives = 141/321 (43%), Gaps = 41/321 (12%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 + V+G+G FG + T TG V+ +K+L + + R +L E+ Sbjct: 14 SDLIHGEVLGKGCFGQ---------AIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKV 64 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 + L HPN++K IG +D+ + E+++ G+L + + + PW RV+ A D Sbjct: 65 MRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQY---PWSQRVSFAKDI 121 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS----------- 233 A G+A+LHS + +I+R++ + N L+ + N ++DFGLAR Sbjct: 122 ASGMAYLHS--MNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPD 179 Query: 234 -YVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVD 292 V+G + APE ++ + + DV+SFG++L EI+ G+ V+ Sbjct: 180 RKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEII-GR--------------VN 224 Query: 293 WARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 YL L V LD P + V+C +P+ RP+ ++ L+ L Sbjct: 225 ADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETL 284 Query: 353 QDNLGKPSQTNPVKDTKKLGF 373 + +L P + GF Sbjct: 285 RMHLAGHLPLGPQLEQLDRGF 305 >4UYA-A nrPDB Length = 340 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 91/359 (25%), Positives = 146/359 (40%), Gaps = 56/359 (15%) Query: 54 SFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ 113 F + + +A +IG GGFG V++ G +AVK Q+ Q Sbjct: 15 YFQGSPVHVAFERLELKELIGAGGFGQVYRATW-----------QGQEVAVKAARQDPEQ 63 Query: 114 GH----REWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF 169 E L HPN+++L G CL+ H LV EF + G+L L R Sbjct: 64 DAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAGRR--- 120 Query: 170 KPLPWFLRVNVALDAAKGLAFLHSDP-VKVIYRDIKASNILLDA--------DYNAKLSD 220 +P + VN A+ A+G+ +LH + V +++RD+K+SNILL + K++D Sbjct: 121 --IPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITD 178 Query: 221 FGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 FGLAR+ G Y + APE + S + SD++S+GVLL E+L+G+ Sbjct: 179 FGLAREWHRT----TKMATAGAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPY- 233 Query: 281 HNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP 340 + A Y + K+ L + PE A + +C +P RP Sbjct: 234 -------RGIDGLAVAYGVAVNKLTLPI-----PSTCPEP---FAKLMKECWQQDPHIRP 278 Query: 341 TMDQVVRALQQLQDNLGKPSQTNPVKDTKK-------LGFKTGTTKSSEKRFTQKPFGR 392 + ++ L ++ + + F TK E R ++ R Sbjct: 279 SFALILEQLTAIEGAVMTEMPQESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTR 337 >5FM2-A nrPDB Length = 355 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 80/365 (21%), Positives = 144/365 (39%), Gaps = 49/365 (13%) Query: 14 FHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEIL-SSTPVKSFTFNE---LKLATRNFRP 69 + + + S + + A++ + + + V +F E + +N Sbjct: 9 PPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVL 68 Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-REWLTEINYLGQL 128 +GEG FG V K + +AVK L + R+ L+E N L Q+ Sbjct: 69 GKTLGEGEFGKVVKA----TAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQV 124 Query: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGA--------------------Y 168 +HP+++KL G C +D LL+ E+ + GSL L Sbjct: 125 NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPD 184 Query: 169 FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGP 228 + L ++ A ++G+ +L +K+++RD+ A NIL+ K+SDFGL+RD Sbjct: 185 ERALTMGDLISFAWQISQGMQYLAE--MKLVHRDLAARNILVAEGRKMKISDFGLSRDVY 242 Query: 229 MGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKE 287 D ++ + A E + +SDV+SFGVLL EI++ G P Sbjct: 243 EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP--- 299 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 ++ ++ + + M + +QC EP RP + + Sbjct: 300 --------------ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISK 345 Query: 348 ALQQL 352 L+++ Sbjct: 346 DLEKM 350 >4R7H-A nrPDB Length = 343 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 86/338 (25%), Positives = 130/338 (38%), Gaps = 53/338 (15%) Query: 45 EILSSTPVKSFTF---------NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTK 95 +I+ S S+TF + + N + +G G FG V + + K Sbjct: 21 KIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEA----TAFGLGK 76 Query: 96 PGTGLVIAVKKLNQEGFQGHREWLT-EINYLGQL-SHPNLVKLIGYCLEDEHRLLVYEFM 153 L +AVK L +E L E+ + L H N+V L+G C L++ E+ Sbjct: 77 EDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYC 136 Query: 154 QKGSLENHLFRR-------------------GAYFKPLPWFLRVNVALDAAKGLAFLHSD 194 G L N L R+ +PL ++ + A+G+AFL S Sbjct: 137 TYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASK 196 Query: 195 PVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSG 254 I+RD+ A N+LL + AK+ DFGLARD V + APE + Sbjct: 197 --NCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDS 254 Query: 255 HLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLD 313 +SDV+S+G+LL EI S G P + K +V + Sbjct: 255 VYTVQSDVWSYGILLWEIFSLGLNPY----------------PGILVNSKFYKLVKDGYQ 298 Query: 314 TQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 + S+ C + EP RPT Q+ LQ+ Sbjct: 299 MAQPAFAPKNIYSIMQACWALEPTHRPTFQQITSFLQE 336 >4E93-A nrPDB Length = 377 Score = 245 bits (625), Expect = 3e-65, Method: Composition-based stats. Identities = 86/323 (26%), Positives = 132/323 (40%), Gaps = 39/323 (12%) Query: 34 STVAAAQKTEGEILS-STPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLT 92 ST K G +L + P + N + IG G FG VF G L Sbjct: 87 STQQPLTKKSGVVLHRAVPKDKWVLNH-----EDLVLGEQIGRGNFGEVFSGRLRAD--- 138 Query: 93 PTKPGTGLVIAVKKLNQEGFQGHR-EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYE 151 ++AVK + + ++L E L Q SHPN+V+LIG C + + +V E Sbjct: 139 ------NTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVME 192 Query: 152 FMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLD 211 +Q G L GA L + + DAA G+ +L S I+RD+ A N L+ Sbjct: 193 LVQGGDFLTFLRTEGAR---LRVKTLLQMVGDAAAGMEYLESKC--CIHRDLAARNCLVT 247 Query: 212 ADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLE 271 K+SDFG++R+ G + + APE ++ G ++ SDV+SFG+LL E Sbjct: 248 EKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWE 307 Query: 272 ILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVR-MASVAVQ 330 S A PY + + PE + + Q Sbjct: 308 TFSLG-----------------ASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQ 350 Query: 331 CLSFEPKSRPTMDQVVRALQQLQ 353 C ++EP RP+ + + LQ ++ Sbjct: 351 CWAYEPGQRPSFSTIYQELQSIR 373 >5UIU-A nrPDB Length = 323 Score = 244 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 110/319 (34%), Positives = 174/319 (54%), Gaps = 28/319 (8%) Query: 47 LSSTPVKSFTFNELKLATRNFRP------DSVIGEGGFGCVFKGWLDESTLTPTKPGTGL 100 +S T SF+F ELK T NF + +GEGGFG V+KG+++ +T Sbjct: 23 VSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTT---------- 72 Query: 101 VIAVKKL----NQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKG 156 +AVKKL + + +++ EI + + H NLV+L+G+ + + LVY +M G Sbjct: 73 -VAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNG 131 Query: 157 SLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA 216 SL + L PL W +R +A AA G+ FLH + I+RDIK++NILLD + A Sbjct: 132 SLLDRLSCLDG-TPPLSWHMRCKIAQGAANGINFLHENHH--IHRDIKSANILLDEAFTA 188 Query: 217 KLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 K+SDFGLAR + +++R++GT Y APE + G + +SD+YSFGV+LLEI++G Sbjct: 189 KISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL-RGEITPKSDIYSFGVVLLEIITGL 247 Query: 277 RALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEP 336 A+D +R + + L+D ++ + +D ++ M SVA QCL + Sbjct: 248 PAVDEHR--EPQLLLDIKEEIEDEEKTIEDYIDKKM-NDADSTSVEAMYSVASQCLHEKK 304 Query: 337 KSRPTMDQVVRALQQLQDN 355 RP + +V + LQ++ + Sbjct: 305 NKRPDIKKVQQLLQEMTAS 323 >5L6P-A nrPDB Length = 298 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 73/316 (23%), Positives = 137/316 (43%), Gaps = 33/316 (10%) Query: 48 SSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL 107 SS P ++ ++ + + VIG G FG V +G L + +A+K L Sbjct: 2 SSDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREV------FVAIKTL 55 Query: 108 NQ-EGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRG 166 + R++L+E + +GQ HPN+++L G + +++ EFM+ +L++ L Sbjct: 56 KVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLND 115 Query: 167 AYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD 226 F + V + A G+ +L + ++RD+ A NIL++++ K+SDFGL+R Sbjct: 116 GQFTVI---QLVGMLRGIAAGMKYL--SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRF 170 Query: 227 GPMGDLSYVSTRVMG---TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHN 282 T +G + APE ++ + SDV+S+G+++ E++S G+R Sbjct: 171 LEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWD- 229 Query: 283 RPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTM 342 S + V+ V+ + + + + C + RP Sbjct: 230 ----------------MSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKF 273 Query: 343 DQVVRALQQLQDNLGK 358 Q+V L +L N Sbjct: 274 SQIVNTLDKLIRNPAS 289 >5X5O-A nrPDB Length = 310 Score = 244 bits (622), Expect = 6e-65, Method: Composition-based stats. Identities = 73/311 (23%), Positives = 131/311 (42%), Gaps = 40/311 (12%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL 119 +++ + + G G FG V++ +AVKKL + Sbjct: 10 VQIKFDDLQFFENCGGGSFGSVYRAKW---------ISQDKEVAVKKLLK--------IE 52 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 E L LSH N+++ G LE + +V E+ GSL +++ + + + + Sbjct: 53 KEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS--EEMDMDHIMT 110 Query: 180 VALDAAKGLAFLHSDPV-KVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR 238 A D AKG+ +LH + KVI+RD+K+ N+++ AD K+ DFG +R Sbjct: 111 WATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF----HNHTTHMS 166 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 ++GT+ + APE + S ++ D YS+GV+L E+L+ + L Sbjct: 167 LVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKG----------------L 210 Query: 299 TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGK 358 + L+V+ A + QC + K RP+ Q++ L+ + ++ Sbjct: 211 EGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSL 270 Query: 359 PSQTNPVKDTK 369 P + N K Sbjct: 271 PDKCNSFLHNK 281 >2XYN-A nrPDB Length = 292 Score = 243 bits (621), Expect = 8e-65, Method: Composition-based stats. Identities = 65/301 (21%), Positives = 132/301 (43%), Gaps = 33/301 (10%) Query: 56 TFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH 115 + ++ ++ + +G G +G V+ G + +LT +AVK L ++ + Sbjct: 23 SMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLT---------VAVKTLKEDTME-V 72 Query: 116 REWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 E+L E + ++ HPNLV+L+G C + +V E+M G+L ++L R + + Sbjct: 73 EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYL--RECNREEVTAV 130 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 + + +A + + +L I+RD+ A N L+ ++ K++DFGL+R GD Sbjct: 131 VLLYMATQISSAMEYLEKK--NFIHRDLAARNCLVGENHVVKVADFGLSRLMT-GDTYTA 187 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWA 294 + APE ++ + +SDV++FGVLL EI + G + Sbjct: 188 HAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLS--------- 238 Query: 295 RPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQD 354 +V +++ + ++ + C + P RP+ + +A + + Sbjct: 239 --------QVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFH 290 Query: 355 N 355 + Sbjct: 291 D 291 >5SYS-A nrPDB Length = 286 Score = 243 bits (621), Expect = 8e-65, Method: Composition-based stats. Identities = 77/305 (25%), Positives = 132/305 (43%), Gaps = 35/305 (11%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 + ++ + R + +G+G FG + G + +T +A+K L G Sbjct: 11 DAWEIPRESLRLEVKLGQGCFGECWMGTWNGTTR----------VAIKTLKP-GTMSPEA 59 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 +L E + +L H LV+L E E +V E+M KGSL + L +G K L Sbjct: 60 FLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFL--KGEMGKYLRLPQL 116 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 V++A A G+A++ + + ++RD++A+NIL+ + K++DFGLAR + + Sbjct: 117 VDMAAQIASGMAYV--ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ- 173 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARP 296 + APE G +SDV+SFG+LL E+ + G+ Sbjct: 174 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPG--------------- 218 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNL 356 R+VL V+ PE + + QC +P+ RPT + + L+ + Sbjct: 219 --MVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTST 276 Query: 357 GKPSQ 361 Q Sbjct: 277 EPQYQ 281 >2VWV-A nrPDB Length = 302 Score = 243 bits (621), Expect = 9e-65, Method: Composition-based stats. Identities = 72/296 (24%), Positives = 132/296 (44%), Gaps = 33/296 (11%) Query: 68 RPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ-EGFQGHREWLTEINYLG 126 + + VIG G FG V +G L + +A+K L + RE+L+E + +G Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKES------CVAIKTLKGGYTERQRREFLSEASIMG 72 Query: 127 QLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAK 186 Q HPN+++L G +++ EFM+ G+L++ L F + V + A Sbjct: 73 QFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVI---QLVGMLRGIAS 129 Query: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG---TY 243 G+ +L + ++RD+ A NIL++++ K+SDFGL+R T +G Sbjct: 130 GMRYLAE--MSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPI 187 Query: 244 GYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLTSKR 302 + APE ++ + SD +S+G+++ E++S G+R S + Sbjct: 188 RWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWD-----------------MSNQ 230 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGK 358 V+ ++ P+ + + + C + +RP QVV AL ++ N Sbjct: 231 DVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPAS 286 >3G0E-A nrPDB Length = 336 Score = 243 bits (620), Expect = 9e-65, Method: Composition-based stats. Identities = 79/318 (24%), Positives = 123/318 (38%), Gaps = 38/318 (11%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 ++ + +G G FG V + + K + +AVK L RE Sbjct: 39 HKWEFPRNRLSFGKTLGAGAFGKVVEA----TAYGLIKSDAAMTVAVKMLKPSAHLTERE 94 Query: 118 WLT-EINYLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF------ 169 L E+ L L +H N+V L+G C L++ E+ G L N L R+ F Sbjct: 95 ALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTS 154 Query: 170 --------KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDF 221 L ++ + AKG+AFL S I+RD+ A NILL K+ DF Sbjct: 155 PAIMEDDELALDLEDLLSFSYQVAKGMAFLASK--NCIHRDLAARNILLTHGRITKICDF 212 Query: 222 GLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDH 281 GLARD V + APE + + SDV+S+G+ L E+ S + Sbjct: 213 GLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYP 272 Query: 282 NRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPT 341 P + + L ++ P E M + C +P RPT Sbjct: 273 GMPVDSKFYKMIKEGFRM------------LSPEHAPAE---MYDIMKTCWDADPLKRPT 317 Query: 342 MDQVVRALQ-QLQDNLGK 358 Q+V+ ++ Q+ ++ Sbjct: 318 FKQIVQLIEKQISESTNH 335 >4UY9-A nrPDB Length = 323 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 83/309 (26%), Positives = 141/309 (45%), Gaps = 49/309 (15%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL 119 L++ + +IG GGFG V++ + G +AVK + + + + Sbjct: 4 LEIDFAELTLEEIIGIGGFGKVYRAFW-----------IGDEVAVKAARHDPDEDISQTI 52 Query: 120 T----EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 E L HPN++ L G CL++ + LV EF + G L L K +P Sbjct: 53 ENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-----SGKRIPPD 107 Query: 176 LRVNVALDAAKGLAFLHSDP-VKVIYRDIKASNILLD--------ADYNAKLSDFGLARD 226 + VN A+ A+G+ +LH + V +I+RD+K+SNIL+ ++ K++DFGLAR+ Sbjct: 108 ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE 167 Query: 227 GPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK 286 GTY + APE + + + SDV+S+GVLL E+L+G+ Sbjct: 168 WHRT----TKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPF------- 216 Query: 287 EENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVV 346 + A Y + K+ L + PE A + C + +P SRP+ ++ Sbjct: 217 -RGIDGLAVAYGVAMNKLALPI-----PSTCPEP---FAKLMEDCWNPDPHSRPSFTNIL 267 Query: 347 RALQQLQDN 355 L ++++ Sbjct: 268 DQLTTIEES 276 >3IO7-A nrPDB Length = 313 Score = 243 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 73/306 (23%), Positives = 133/306 (43%), Gaps = 16/306 (5%) Query: 56 TFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH 115 + N + R+ + +G+G FG V D P + TG V+AVKKL + Sbjct: 19 SHNMTQFEERHLKFLQQLGKGNFGSVEMCRYD-----PLQDNTGEVVAVKKLQHSTEEHL 73 Query: 116 REWLTEINYLGQLSHPNLVKLIGYCLE--DEHRLLVYEFMQKGSLENHLFRRGAYFKPLP 173 R++ EI L L H N+VK G C + L+ E++ GSL ++L + + + Sbjct: 74 RDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK---ERID 130 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 + KG+ +L + I+RD+ NIL++ + K+ DFGL + P D Sbjct: 131 HIKLLQYTSQICKGMEYL--GTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQ-DKE 187 Query: 234 YVSTRVMG--TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 Y + G + APE ++ + SDV+SFGV+L E+ + + PA+ ++ Sbjct: 188 YYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTY-IEKSKSPPAEFMRMI 246 Query: 292 DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 + ++ ++ N + + +C + RP+ + + Q Sbjct: 247 GNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQ 306 Query: 352 LQDNLG 357 ++DN+ Sbjct: 307 IRDNMA 312 >3I81-A nrPDB Length = 315 Score = 243 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 65/304 (21%), Positives = 137/304 (45%), Gaps = 29/304 (9%) Query: 55 FTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG 114 + +E ++A +G+G FG V++G K +A+K +N+ Sbjct: 8 YVPDEWEVAREKITMSRELGQGSFGMVYEGVAK----GVVKDEPETRVAIKTVNEAASMR 63 Query: 115 HR-EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFK--- 170 R E+L E + + + + ++V+L+G + + L++ E M +G L+++L + Sbjct: 64 ERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNP 123 Query: 171 ---PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG 227 P + +A + A G+A+L + K ++RD+ A N ++ D+ K+ DFG+ RD Sbjct: 124 VLAPPSLSKMIQMAGEIADGMAYL--NANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI 181 Query: 228 PMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE 287 D + + + +PE + G SDV+SFGV+L EI + Sbjct: 182 YETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIAT------------- 228 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 L + L++++ + +++ L + + C + PK RP+ +++ Sbjct: 229 --LAEQPYQGLSNEQVLRFVMEGGL-LDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS 285 Query: 348 ALQQ 351 ++++ Sbjct: 286 SIKE 289 >2DQ7-X nrPDB Length = 283 Score = 243 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 72/305 (23%), Positives = 130/305 (42%), Gaps = 35/305 (11%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 + ++ + + +G G FG V+ G + +T +A+K L G Sbjct: 2 DVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNT----------KVAIKTLKP-GTMSPES 50 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 +L E + +L H LV+L E E +V E+M KGSL + L + + L Sbjct: 51 FLEEAQIMKKLKHDKLVQLYAVVSE-EPIYIVTEYMNKGSLLDFL--KDGEGRALKLPNL 107 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 V++A A G+A++ + + I+RD++++NIL+ K++DFGLAR + + Sbjct: 108 VDMAAQVAAGMAYI--ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQ- 164 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARP 296 + APE G +SDV+SFG+LL E+++ G+ Sbjct: 165 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPG--------------- 209 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNL 356 + R+VL V+ + + + + + C +P+ RPT + + L+ Sbjct: 210 --MNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTAT 267 Query: 357 GKPSQ 361 Q Sbjct: 268 EPQYQ 272 >4PDO-A nrPDB Length = 299 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 73/288 (25%), Positives = 133/288 (46%), Gaps = 30/288 (10%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWLTEINYLGQL 128 VIG G FG V+KG L S+ P +A+K L + R ++L E +GQ Sbjct: 39 QKVIGAGEFGEVYKGMLKTSSGKKEVP-----VAIKTLKAGYTEKQRVDFLGEAGIMGQF 93 Query: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 SH N+++L G + + +++ E+M+ G+L+ L + F L V + A G+ Sbjct: 94 SHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVL---QLVGMLRGIAAGM 150 Query: 189 AFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMG-DLSYVSTRVMGTYGYAA 247 +L + ++RD+ A NIL++++ K+SDFGL+R + +Y ++ + A Sbjct: 151 KYL--ANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTA 208 Query: 248 PEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLTSKRKVLL 306 PE +S + SDV+SFG+++ E+++ G+R S +V+ Sbjct: 209 PEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWE-----------------LSNHEVMK 251 Query: 307 IVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQD 354 +++ + + + +QC E RP +V L +L Sbjct: 252 AINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIR 299 >2HK5-A nrPDB Length = 270 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 74/303 (24%), Positives = 132/303 (43%), Gaps = 35/303 (11%) Query: 52 VKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEG 111 K + + ++ + + + +G G FG V+ ++ T +AVK + G Sbjct: 2 QKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT----------KVAVKTMKP-G 50 Query: 112 FQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKP 171 +L E N + L H LVKL + E ++ EFM KGSL + L +P Sbjct: 51 SMSVEAFLAEANVMKTLQHDKLVKLHAV-VTKEPIYIITEFMAKGSLLDFLKSDEGSKQP 109 Query: 172 LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGD 231 LP ++ + A+G+AF+ I+RD++A+NIL+ A K++DFGLAR + Sbjct: 110 LPK--LIDFSAQIAEGMAFIEQR--NYIHRDLRAANILVSASLVCKIADFGLARVIEDNE 165 Query: 232 LSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENL 290 + + APE ++ G +SDV+SFG+LL+EI++ G+ Sbjct: 166 YTA-REGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPG--------- 215 Query: 291 VDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQ 350 S +V+ ++ + ++ ++C P+ RPT + + L Sbjct: 216 --------MSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLD 267 Query: 351 QLQ 353 + Sbjct: 268 DFE 270 >5X02-A nrPDB Length = 347 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 75/312 (24%), Positives = 117/312 (37%), Gaps = 42/312 (13%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW 118 + + N V+G G FG V + +K G + +AVK L ++ RE Sbjct: 42 KWEFPRENLEFGKVLGSGAFGKVMNA----TAYGISKTGVSIQVAVKMLKEKADSSEREA 97 Query: 119 LT-EINYLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKP----- 171 L E+ + QL SH N+V L+G C L++E+ G L N+L + F Sbjct: 98 LMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEY 157 Query: 172 --------------LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAK 217 L + + A AKG+ FL ++RD+ A N+L+ K Sbjct: 158 ENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKS--CVHRDLAARNVLVTHGKVVK 215 Query: 218 LSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKR 277 + DFGLARD V + APE + G +SDV+S+G+LL EI S Sbjct: 216 ICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGV 275 Query: 278 ALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPK 337 P ++ N + + C +F+ + Sbjct: 276 NPYPGIPVDA---------------NFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSR 320 Query: 338 SRPTMDQVVRAL 349 RP+ + L Sbjct: 321 KRPSFPNLTSFL 332 >4XUF-A nrPDB Length = 297 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 75/312 (24%), Positives = 117/312 (37%), Gaps = 42/312 (13%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW 118 + + N V+G G FG V + +K G + +AVK L ++ RE Sbjct: 3 KWEFPRENLEFGKVLGSGAFGKVMNA----TAYGISKTGVSIQVAVKMLKEKADSSEREA 58 Query: 119 LT-EINYLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKP----- 171 L E+ + QL SH N+V L+G C L++E+ G L N+L + F Sbjct: 59 LMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEY 118 Query: 172 --------------LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAK 217 L + + A AKG+ FL ++RD+ A N+L+ K Sbjct: 119 ENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKS--CVHRDLAARNVLVTHGKVVK 176 Query: 218 LSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKR 277 + DFGLARD V + APE + G +SDV+S+G+LL EI S Sbjct: 177 ICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGV 236 Query: 278 ALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPK 337 P ++ N + + C +F+ + Sbjct: 237 NPYPGIPVDA---------------NFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSR 281 Query: 338 SRPTMDQVVRAL 349 RP+ + L Sbjct: 282 KRPSFPNLTSFL 293 >2W1I-A nrPDB Length = 326 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 131/305 (42%), Gaps = 16/305 (5%) Query: 57 FNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR 116 + + R+ + +G+G FG V D P + TG V+AVKKL + R Sbjct: 33 RDPTQFEERHLKFLQQLGKGNFGSVEMCRYD-----PLQDNTGEVVAVKKLQHSTEEHLR 87 Query: 117 EWLTEINYLGQLSHPNLVKLIGYCLE--DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPW 174 ++ EI L L H N+VK G C + L+ E++ GSL ++L + + + Sbjct: 88 DFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHK---ERIDH 144 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSY 234 + KG+ +L + I+RD+ NIL++ + K+ DFGL + P D Y Sbjct: 145 IKLLQYTSQICKGMEYL--GTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQ-DKEY 201 Query: 235 VSTRVMG--TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVD 292 + G + APE ++ + SDV+SFGV+L E+ + + PA+ ++ Sbjct: 202 YKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTY-IEKSKSPPAEFMRMIG 260 Query: 293 WARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 + ++ ++ N + + +C + RP+ + + Q+ Sbjct: 261 NDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQI 320 Query: 353 QDNLG 357 +D + Sbjct: 321 RDQMA 325 >2J0K-A nrPDB Length = 656 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 74/330 (22%), Positives = 129/330 (39%), Gaps = 33/330 (10%) Query: 28 SSRKSSSTVAAAQKTEGEILSSTPVKSF-TFNELKLATRNFRPDSVIGEGGFGCVFKGWL 86 +S + + EI+ + + + ++ IGEG FG V +G Sbjct: 352 QGVRSHTVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQG-- 409 Query: 87 DESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYLGQLSHPNLVKLIGYCLEDEH 145 + + + +A+K RE +L E + Q HP++VKLIG E Sbjct: 410 ----IYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITE-NP 464 Query: 146 RLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKA 205 ++ E G L + L R L + A + LA+L S + ++RDI A Sbjct: 465 VWIIMELCTLGELRSFLQVRKFS---LDLASLILYAYQLSTALAYLESK--RFVHRDIAA 519 Query: 206 SNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSF 265 N+L+ A KL DFGL+R Y +++ + APE ++ + SDV+ F Sbjct: 520 RNVLVSATDCVKLGDFGLSRYME-DSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMF 578 Query: 266 GVLLLEILS-GKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRM 324 GV + EIL G + + V+ ++N P + Sbjct: 579 GVCMWEILMHGVKPFQGVK-----------------NNDVIGRIENGERLPMPPNCPPTL 621 Query: 325 ASVAVQCLSFEPKSRPTMDQVVRALQQLQD 354 S+ +C +++P RP ++ L + + Sbjct: 622 YSLMTKCWAYDPSRRPRFTELKAQLSTILE 651 >4EBW-A nrPDB Length = 304 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 121/298 (40%), Gaps = 32/298 (10%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE- 117 + ++ IGEG FG V +G + + L +A+K RE Sbjct: 32 DYEIQRERIELGRCIGEGQFGDVHQG------IYMSPENPALAVAIKTCKNCTSDSVREK 85 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 +L E + Q HP++VKLIG E ++ E G L + L R L Sbjct: 86 FLQEALTMRQFDHPHIVKLIGVITE-NPVWIIMELCTLGELRSFLQVRKYS---LDLASL 141 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 + A + LA+L S + ++RDI A N+L+ ++ KL DFGL+R Y ++ Sbjct: 142 ILYAYQLSTALAYLESK--RFVHRDIAARNVLVSSNDCVKLGDFGLSRYME-DSTYYKAS 198 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARP 296 + + APE ++ + SDV+ FGV + EIL G + + Sbjct: 199 KGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVK------------- 245 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQD 354 V+ ++N P + S+ +C +++P RP ++ L + + Sbjct: 246 ----NNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILE 299 >3KUL-B nrPDB Length = 325 Score = 240 bits (613), Expect = 6e-64, Method: Composition-based stats. Identities = 73/326 (22%), Positives = 132/326 (40%), Gaps = 31/326 (9%) Query: 33 SSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLT 92 + Q P ++ ++ + +IG G G V G L Sbjct: 17 QGKLPEPQFYAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQR 76 Query: 93 PTKPGTGLVIAVKKLNQ-EGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYE 151 +A+K L + R++L+E + +GQ HPN+++L G ++V E Sbjct: 77 DV------PVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTE 130 Query: 152 FMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLD 211 +M+ GSL+ L F V + G+ +L + ++RD+ A N+L+D Sbjct: 131 YMENGSLDTFLRTHDGQF---TIMQLVGMLRGVGAGMRYL--SDLGYVHRDLAARNVLVD 185 Query: 212 ADYNAKLSDFGLARDGPMG-DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLL 270 ++ K+SDFGL+R D +Y +T + APE ++ ++ SDV+SFGV++ Sbjct: 186 SNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMW 245 Query: 271 EILS-GKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAV 329 E+L+ G+R + + R V+ V+ + + + Sbjct: 246 EVLAYGERPYWN-----------------MTNRDVISSVEEGYRLPAPMGCPHALHQLML 288 Query: 330 QCLSFEPKSRPTMDQVVRALQQLQDN 355 C + RP Q+V L L + Sbjct: 289 DCWHKDRAQRPRFSQIVSVLDALIRS 314 >3SXS-A nrPDB Length = 268 Score = 240 bits (613), Expect = 7e-64, Method: Composition-based stats. Identities = 78/300 (26%), Positives = 128/300 (42%), Gaps = 35/300 (11%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL 119 ++L +G G FG V G +AVK + +EG E+ Sbjct: 3 MELKREEITLLKELGSGQFGVVKLGKWKGQYD----------VAVKMI-KEGSMSEDEFF 51 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 E + +LSHP LVK G C ++ +V E++ G L N+L G +P + Sbjct: 52 QEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEP---SQLLE 108 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 + D +G+AFL S I+RD+ A N L+D D K+SDFG+ R + D S Sbjct: 109 MCYDVCEGMAFLESHQ--FIHRDLAARNCLVDRDLCVKVSDFGMTRYV-LDDQYVSSVGT 165 Query: 240 MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYL 298 ++APE +++SDV++FG+L+ E+ S GK D L Sbjct: 166 KFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKMPYD-----------------L 208 Query: 299 TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGK 358 + +V+L V + + + C P+ RPT Q++ +++ L++ Sbjct: 209 YTNSEVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDKH 268 >4H1J-A nrPDB Length = 293 Score = 240 bits (613), Expect = 8e-64, Method: Composition-based stats. Identities = 72/295 (24%), Positives = 131/295 (44%), Gaps = 32/295 (10%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLT 120 +A + + ++GEG FG V++G + G + +AVK ++ ++E +++ Sbjct: 21 IAREDVVLNRILGEGFFGEVYEG------VYTNHKGEKINVAVKTCKKDCTLDNKEKFMS 74 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 E + L HP++VKLIG E+E ++ E G L ++L R K L L Sbjct: 75 EAVIMKNLDHPHIVKLIGII-EEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVL---Y 130 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 +L K +A+L S + ++RDI NIL+ + KL DFGL+R D Y ++ Sbjct: 131 SLQICKAMAYLES--INCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDY-YKASVTR 187 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLT 299 + +PE ++ SDV+ F V + EILS GK+ + Sbjct: 188 LPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPF-----------------FWL 230 Query: 300 SKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQD 354 + V+ +++ + ++ +C ++P RP ++V +L + Sbjct: 231 ENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQ 285 >4CFF-A nrPDB Length = 571 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 72/309 (23%), Positives = 123/309 (39%), Gaps = 42/309 (13%) Query: 45 EILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAV 104 E+L P+ ++ ++ ++ +G G FG V G TG +AV Sbjct: 13 EVLFQGPMAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIG---------EHQLTGHKVAV 63 Query: 105 KKLNQEGFQGHR---EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENH 161 K LN++ + + EI L HP+++KL +V E++ G L ++ Sbjct: 64 KILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDY 123 Query: 162 LFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDF 221 + + G + + + + H V++RD+K N+LLDA NAK++DF Sbjct: 124 ICKHGRVEE----MEARRLFQQILSAVDYCHRHM--VVHRDLKPENVLLDAHMNAKIADF 177 Query: 222 GLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHL-NARSDVYSFGVLLLEILSGKRALD 280 GL+ G+ S G+ YAAPE +S D++S GV+L +L G D Sbjct: 178 GLSNMMSDGEFLRTS---CGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD 234 Query: 281 HNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVR-MASVAVQCLSFEPKSR 339 + R Y+PE R +A++ + L +P R Sbjct: 235 DEHVPTLFKKI-------------------RGGVFYIPEYLNRSVATLLMHMLQVDPLKR 275 Query: 340 PTMDQVVRA 348 T+ + Sbjct: 276 ATIKDIREH 284 >4E20-A nrPDB Length = 290 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 85/295 (28%), Positives = 127/295 (43%), Gaps = 18/295 (6%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYL 125 + +GEG FG V D PT GTG ++AVK L + R W EI L Sbjct: 10 LKKIRDLGEGHFGKVSLYCYD-----PTNDGTGEMVAVKALKEGCGPQLRSGWQREIEIL 64 Query: 126 GQLSHPNLVKLIGYCLEDEHRL--LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 L H ++VK G C + + LV E++ GSL ++L R L + A Sbjct: 65 RTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQL-----LLFAQQ 119 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSY-VSTRVMGT 242 +G+A+LH+ I+R + A N+LLD D K+ DFGLA+ P G Y V Sbjct: 120 ICEGMAYLHAQ--HYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSP 177 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 + APE + SDV+SFGV L E+L+ + + + K L+ + +T R Sbjct: 178 VFWYAPECLKECKFYYASDVWSFGVTLYELLTYCDS-NQSPHTKFTELIGHTQGQMTVLR 236 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLG 357 + +++ + + C E RPT +V LQ Q+ Sbjct: 237 -LTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPILQTAQEKYQ 290 >3DAK-A nrPDB Length = 290 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 69/298 (23%), Positives = 122/298 (40%), Gaps = 28/298 (9%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ-GHREW 118 + ++ VIG G V + +A+K++N E Q E Sbjct: 5 WSINRDDYELQEVIGSGATAVVQAAYCA---------PKKEKVAIKRINLEKCQTSMDEL 55 Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFK----PLPW 174 L EI + Q HPN+V + + LV + + GS+ + + A + L Sbjct: 56 LKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDE 115 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMG---D 231 + + +GL +LH + I+RD+KA NILL D + +++DFG++ G Sbjct: 116 STIATILREVLEGLEYLHKN--GQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDIT 173 Query: 232 LSYVSTRVMGTYGYAAPEYMSS-GHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENL 290 + V +GT + APE M + ++D++SFG+ +E+ +G P K Sbjct: 174 RNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVL-- 231 Query: 291 VDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 LT + + D + L + + CL +P+ RPT +++R Sbjct: 232 ------MLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRH 283 >4LG4-A nrPDB Length = 299 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 75/288 (26%), Positives = 126/288 (43%), Gaps = 33/288 (11%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 K F +GEG +G VFK E +G V+A+K++ E +E + Sbjct: 7 KQPEEVFDVLEKLGEGSYGSVFKAIHKE---------SGQVVAIKQVPVES--DLQEIIK 55 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 EI+ + Q P +VK G ++ +V E+ GS+ + + R K L + Sbjct: 56 EISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRN---KTLIEDEIATI 112 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 KGL +LH ++ I+R+IKA NILL+ + +AKL+DFG+A G + D V+ Sbjct: 113 LKSTLKGLEYLH--FMRKIHRNIKAGNILLNTEGHAKLADFGVA--GQLTDTMAKRNTVI 168 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 GT + APE + N +D++S G+ +E+ GK P + ++ P Sbjct: 169 GTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFR 228 Query: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 K ++ + +CL P+ R T Q+++ Sbjct: 229 KPELW---------------SDDFTDFVKKCLVKNPEQRATATQLLQH 261 >6GVJ-A nrPDB Length = 429 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 78/383 (20%), Positives = 147/383 (38%), Gaps = 56/383 (14%) Query: 3 SCFSSRV-KADIFHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNE-L 60 SCF + V K D + S YG ++ + A ++L+S+ + NE + Sbjct: 85 SCFRTPVVKNDFPPACQLSTPYGQPACFQQQQHQILATPLQNLQVLASS-----SANECI 139 Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE--GFQGHREW 118 + R + IG GG VF+ ++ + A+K +N E Q + Sbjct: 140 SVKGRIYSILKQIGSGGSSKVFQVLNEK----------KQIYAIKYVNLEEADNQTLDSY 189 Query: 119 LTEINYLGQLS--HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 EI YL +L +++L Y + D++ +V E L + L ++ K + + Sbjct: 190 RNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKK----KSIDPWE 244 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 R + + + + +H +++ D+K +N L+ D KL DFG+A S V Sbjct: 245 RKSYWKNMLEAVHTIHQH--GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVK 301 Query: 237 TRVMGTYGYAAPEYMSSGHLNAR-----------SDVYSFGVLLLEILSGKRALDHNRPA 285 +GT Y PE + + SDV+S G +L + GK Sbjct: 302 DSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------ 355 Query: 286 KEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQV 345 + + K+ I+D + ++ + V CL +PK R ++ ++ Sbjct: 356 ---------QQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPEL 406 Query: 346 VRA-LQQLQDNLGKPSQTNPVKD 367 + Q+Q + ++ Sbjct: 407 LAHPYVQIQTHPVNQMAKGTTEE 429 >3CJF-A nrPDB Length = 309 Score = 238 bits (608), Expect = 3e-63, Method: Composition-based stats. Identities = 85/311 (27%), Positives = 122/311 (39%), Gaps = 34/311 (10%) Query: 54 SFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ-EGF 112 + ++ + +G G FG V + K T +AVK L + Sbjct: 16 PYDASKWEFPRDRLNLGKPLGRGAFGQVIEA----DAFGIDKTATCRTVAVKMLKEGATH 71 Query: 113 QGHREWLTEINYLGQLSHP-NLVKLIGYCLEDEHRLLVY-EFMQKGSLENHLFRRGAYFK 170 HR ++E+ L + H N+V L+G C + L+V EF + G+L +L + F Sbjct: 72 SEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFV 131 Query: 171 P--------LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFG 222 P L + + AKG+ FL S K I+RD+ A NILL K+ DFG Sbjct: 132 PYKDLYKDFLTLEHLICYSFQVAKGMEFLASR--KCIHRDLAARNILLSEKNVVKICDFG 189 Query: 223 LARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDH 281 LARD + APE + +SDV+SFGVLL EI S G Sbjct: 190 LARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPG 249 Query: 282 NRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPT 341 + +E R++ R PE M + C EP RPT Sbjct: 250 VKIDEEF------------CRRLKEGTRMRAPDYTTPE----MYQTMLDCWHGEPSQRPT 293 Query: 342 MDQVVRALQQL 352 ++V L L Sbjct: 294 FSELVEHLGNL 304 >6AO5-A nrPDB Length = 362 Score = 238 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 75/288 (26%), Positives = 126/288 (43%), Gaps = 33/288 (11%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 K F +GEG +G VFK E +G V+A+K++ E +E + Sbjct: 6 KQPEEVFDVLEKLGEGSYGSVFKAIHKE---------SGQVVAIKQVPVES--DLQEIIK 54 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 EI+ + Q P +VK G ++ +V E+ GS+ + + R K L + Sbjct: 55 EISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRN---KTLIEDEIATI 111 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 KGL +LH ++ I+R+IKA NILL+ + +AKL+DFG+A G + D V+ Sbjct: 112 LKSTLKGLEYLH--FMRKIHRNIKAGNILLNTEGHAKLADFGVA--GQLTDTMAKRNTVI 167 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 GT + APE + N +D++S G+ +E+ GK P + ++ P Sbjct: 168 GTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFR 227 Query: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 K ++ + +CL P+ R T Q+++ Sbjct: 228 KPELW---------------SDDFTDFVKKCLVKNPEQRATATQLLQH 260 >3BBT-B nrPDB Length = 328 Score = 238 bits (606), Expect = 5e-63, Method: Composition-based stats. Identities = 68/296 (22%), Positives = 129/296 (43%), Gaps = 30/296 (10%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE-GFQGHREWLT 120 L + V+G G FG V+KG P + +A+K LN+ G + + E++ Sbjct: 12 LKETELKRVKVLGSGAFGTVYKG-----IWVPEGETVKIPVAIKILNETTGPKANVEFMD 66 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 E + + HP+LV+L+G CL LV + M G L ++ + L +N Sbjct: 67 EALIMASMDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDN---IGSQLLLNW 122 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 + AKG+ +L ++++RD+ A N+L+ + + K++DFGLAR + Y + Sbjct: 123 CVQIAKGMMYLEER--RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGK 180 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLT 299 + A E + +SDV+S+GV + E+++ G + D Sbjct: 181 MPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIP---------------- 224 Query: 300 SKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 R++ +++ P + + V V+C + SRP ++ ++ + Sbjct: 225 -TREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARD 279 >5HLW-A nrPDB Length = 299 Score = 237 bits (605), Expect = 6e-63, Method: Composition-based stats. Identities = 81/289 (28%), Positives = 131/289 (45%), Gaps = 31/289 (10%) Query: 68 RPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ-EGFQGHREWLTEINYLG 126 + VIG G FGCV+ G L ++ AVK LN+ ++LTE + Sbjct: 23 HFNEVIGRGHFGCVYHGTLLDNDGKKIH------CAVKSLNRITDIGEVSQFLTEGIIMK 76 Query: 127 QLSHPNLVKLIGYCLE-DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 SHPN++ L+G CL + L+V +M+ G L N + + L A Sbjct: 77 DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKD---LIGFGLQVA 133 Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV--STRVMGTY 243 KG+ +L S K ++RD+ A N +LD + K++DFGLARD + V T Sbjct: 134 KGMKYLASK--KFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPV 191 Query: 244 GYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRK 303 + A E + + +SDV+SFGVLL E+++ P + N D YL R+ Sbjct: 192 KWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAP-----PYPDVNTFDITV-YLLQGRR 245 Query: 304 VLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 + L +Y P+ + V ++C + + RP+ ++V + + Sbjct: 246 L-------LQPEYCPDP---LYEVMLKCWHPKAEMRPSFSELVSRISAI 284 >3ZBF-A nrPDB Length = 322 Score = 237 bits (605), Expect = 6e-63, Method: Composition-based stats. Identities = 78/300 (26%), Positives = 133/300 (44%), Gaps = 34/300 (11%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLV-IAVKKLNQEGFQGHR-EWL 119 ++G G FG V++G + + G+G + +AVK L + + E+L Sbjct: 30 FPREKLTLRLLLGSGAFGEVYEG----TAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFL 85 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGA---YFKPLPWFL 176 E + + + +HPN++K +G CL +E + ++ E M+ G L +L + Y L Sbjct: 86 KEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVD 145 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILL-----DADYNAKLSDFGLARDGPMGD 231 V++ +D +KG +L + + I+RD+ A N L+ + K+ DFGLARD D Sbjct: 146 LVDLCVDISKGCVYL--ERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKND 203 Query: 232 LSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENL 290 + + APE + G +SDV+SFG+L+ EIL+ G + + Sbjct: 204 YYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAH-------- 255 Query: 291 VDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQ 350 S VL V + + ++ QC + EP RPT ++ LQ Sbjct: 256 ---------SNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ 306 >3QGY-A nrPDB Length = 286 Score = 237 bits (605), Expect = 6e-63, Method: Composition-based stats. Identities = 78/295 (26%), Positives = 135/295 (45%), Gaps = 35/295 (11%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTE 121 + IG G FG V G+ +A+K + +EG +++ E Sbjct: 24 IDPSELTFVQEIGSGQFGLVHLGYWLNKD----------KVAIKTI-KEGSMSEDDFIEE 72 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 + +LSHP LV+L G CLE LV+EFM+ G L ++L + F + + Sbjct: 73 AEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAET---LLGMC 129 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 LD +G+A+L + VI+RD+ A N L+ + K+SDFG+ R + D ST Sbjct: 130 LDVCEGMAYL--EEACVIHRDLAARNCLVGENQVIKVSDFGMTR-FVLDDQYTSSTGTKF 186 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLTS 300 +A+PE S +++SDV+SFGVL+ E+ S GK ++ + E + D + + Sbjct: 187 PVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENR--SNSEVVEDISTGFRLY 244 Query: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 K ++ + + + C P+ RP +++R L ++ ++ Sbjct: 245 KPRL---------------ASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAES 284 >3C1X-A nrPDB Length = 373 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 82/289 (28%), Positives = 131/289 (45%), Gaps = 31/289 (10%) Query: 68 RPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ-EGFQGHREWLTEINYLG 126 + VIG G FGCV+ G L ++ AVK LN+ ++LTE + Sbjct: 92 HFNEVIGRGHFGCVYHGTLLDNDGKKIH------CAVKSLNRITDIGEVSQFLTEGIIMK 145 Query: 127 QLSHPNLVKLIGYCLE-DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 SHPN++ L+G CL + L+V +M+ G L N + + L A Sbjct: 146 DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKD---LIGFGLQVA 202 Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMG--DLSYVSTRVMGTY 243 KG+ FL S K ++RD+ A N +LD + K++DFGLARD D + T Sbjct: 203 KGMKFLASK--KFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPV 260 Query: 244 GYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRK 303 + A E + + +SDV+SFGVLL E+++ P + N D YL R+ Sbjct: 261 KWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAP-----PYPDVNTFDITV-YLLQGRR 314 Query: 304 VLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 + L +Y P+ + V ++C + + RP+ ++V + + Sbjct: 315 L-------LQPEYCPDP---LYEVMLKCWHPKAEMRPSFSELVSRISAI 353 >3DTC-A nrPDB Length = 271 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 82/306 (26%), Positives = 137/306 (44%), Gaps = 49/306 (16%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL 119 L++ + +IG GGFG V++ + G +AVK + + + + Sbjct: 2 LEIDFAELTLEEIIGIGGFGKVYRAFW-----------IGDEVAVKAARHDPDEDISQTI 50 Query: 120 T----EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 E L HPN++ L G CL++ + LV EF + G L L K +P Sbjct: 51 ENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL-----SGKRIPPD 105 Query: 176 LRVNVALDAAKGLAFLHSDP-VKVIYRDIKASNILLD--------ADYNAKLSDFGLARD 226 + VN A+ A+G+ +LH + V +I+RD+K+SNIL+ ++ K++DFGLAR+ Sbjct: 106 ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE 165 Query: 227 GPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK 286 G Y + APE + + + SDV+S+GVLL E+L+G+ Sbjct: 166 WHRT----TKMSAAGAYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPF------- 214 Query: 287 EENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVV 346 + A Y + K+ L + PE A + C + +P SRP+ ++ Sbjct: 215 -RGIDGLAVAYGVAMNKLALPI-----PSTCPEP---FAKLMEDCWNPDPHSRPSFTNIL 265 Query: 347 RALQQL 352 L + Sbjct: 266 DQLTTI 271 >5KCV-A nrPDB Length = 460 Score = 236 bits (601), Expect = 2e-62, Method: Composition-based stats. Identities = 77/326 (23%), Positives = 124/326 (38%), Gaps = 49/326 (15%) Query: 31 KSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDEST 90 +S S + E E+ + P T NE F ++G+G FG V Sbjct: 135 RSGSPSDNSGAEEMEVSLAKPKHRVTMNE-------FEYLKLLGKGTFGKV--------- 178 Query: 91 LTPTKPGTGLVIAVKKLNQEGFQGHREW---LTEINYLGQLSHPNLVKLIGYCLEDEHRL 147 + + TG A+K L +E E LTE L HP L L + Sbjct: 179 ILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLC 238 Query: 148 LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASN 207 V E+ G L HL R + + F + L +LHS+ V+YRD+K N Sbjct: 239 FVMEYANGGELFFHLSRERVFSEDRARFYGA----EIVSALDYLHSEK-NVVYRDLKLEN 293 Query: 208 ILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGV 267 ++LD D + K++DFGL ++G + GT Y APE + D + GV Sbjct: 294 LMLDKDGHIKITDFGLCKEGIKDGAT--MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGV 351 Query: 268 LLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASV 327 ++ E++ G+ + K L+ L+ + R PE ++ + Sbjct: 352 VMYEMMCGRLPFYNQDHEKLFELI--------------LMEEIRFPRTLGPEAKSLLSGL 397 Query: 328 AVQCLSFEPKSRP-----TMDQVVRA 348 L +PK R ++++ Sbjct: 398 ----LKKDPKQRLGGGSEDAKEIMQH 419 >5H2U-A nrPDB Length = 267 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 76/294 (25%), Positives = 128/294 (43%), Gaps = 34/294 (11%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL 119 ++ F +G G FG VF+G + + +A+K ++++ + Sbjct: 1 MERPREEFTLCRKLGSGYFGEVFEGLWKDR----------VQVAIKVISRDNLLHQQMLQ 50 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 +EI + +L H +++ L + ++ E M KGSL L R + K LP ++ Sbjct: 51 SEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELL--RDSDEKVLPVSELLD 108 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 +A A+G+ +L S I+RD+ A NIL+ + K+ DFGLAR + + Y+S Sbjct: 109 IAWQVAEGMCYLESQ--NYIHRDLAARNILVGENTLCKVGDFGLARL--IKEDVYLSHDH 164 Query: 240 MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYL 298 Y + APE +S GH + +SDV+SFG+LL E+ S G+ Sbjct: 165 NIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPG----------------- 207 Query: 299 TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 S + L VD E + + + C +P+ RPT + L Sbjct: 208 MSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPTFKALRERLSSF 261 >5WNL-A nrPDB Length = 342 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 85/329 (25%), Positives = 139/329 (42%), Gaps = 39/329 (11%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR--EWLTEIN 123 F +G GGFG V+K + T L A+K E L E Sbjct: 21 EFAGWEKVGSGGFGQVYK-------VRHVHWKTWL--AIKCSPSLHVDDRERMELLEEAK 71 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 + ++ + G C E LV E+M+ GSLE L +PLPW LR + + Sbjct: 72 KMEMAKFRYILPVYGICQEPVG--LVMEYMETGSLEKLLA-----SEPLPWDLRFRIVHE 124 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR-DGPMGDLSYVSTRVMGT 242 A G+ FLH +++ ++K +NILLDA Y+ K+SDFGLA+ +G + GT Sbjct: 125 TAVGMNFLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGT 184 Query: 243 YGYAAPEYMSSGH--LNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 Y PE + + + DVYSF +++ +L+ K+ A E+N++ + Sbjct: 185 IAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPF-----ADEKNILHIMMKVVKG 239 Query: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPS 360 R L + + P + + +C +P+ RPT ++ + L + Sbjct: 240 HRPELPPI-----CRPRPRACASLIGLMQRCWHADPQVRPTFQEITSETEDLCEK----- 289 Query: 361 QTNPVKDTKKLGFKTGTTKSSEKRFTQKP 389 P ++ K L + G S E + +P Sbjct: 290 ---PDEEVKDLAHEPGEKSSLESKSEARP 315 >4QMW-A nrPDB Length = 310 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 74/287 (25%), Positives = 120/287 (41%), Gaps = 36/287 (12%) Query: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN-QEGFQGHREWLTE 121 F IG+G FG VFKG T V+A+K ++ +E + E Sbjct: 27 PEELFTKLEKIGKGSFGEVFKG---------IDNRTQKVVAIKIIDLEEAEDEIEDIQQE 77 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 I L Q P + K G L+D ++ E++ GS + L PL + Sbjct: 78 ITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLL-----EPGPLDETQIATIL 132 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 + KGL +LHS+ I+RDIKA+N+LL KL+DFG+A G + D +G Sbjct: 133 REILKGLDYLHSEKK--IHRDIKAANVLLSEHGEVKLADFGVA--GQLTDTQIKRNTFVG 188 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK 301 T + APE + ++++D++S G+ +E+ G+ P Sbjct: 189 TPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPM---------------- 232 Query: 302 RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 KVL ++ + + CL+ EP RPT ++++ Sbjct: 233 -KVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKH 278 >4CFH-A nrPDB Length = 493 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 72/308 (23%), Positives = 122/308 (39%), Gaps = 40/308 (12%) Query: 45 EILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAV 104 E+L P+ ++ ++ ++ +G G FG V G + TG +AV Sbjct: 13 EVLFQGPMAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHE---------LTGHKVAV 63 Query: 105 KKLNQEGFQGHR---EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENH 161 K LN++ + + EI L HP+++KL +V E++ G L ++ Sbjct: 64 KILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDY 123 Query: 162 LFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDF 221 + + G + + G+ + H V++RD+K N+LLDA NAK++DF Sbjct: 124 ICKNGRLDEKESR----RLFQQILSGVDYCHRHM--VVHRDLKPENVLLDAHMNAKIADF 177 Query: 222 GLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHL-NARSDVYSFGVLLLEILSGKRALD 280 GL+ G+ S G+ YAAPE +S D++S GV+L +L G D Sbjct: 178 GLSNMMSDGEFLRTS---CGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFD 234 Query: 281 HNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP 340 + + Y QYL + S+ L +P R Sbjct: 235 DDHVPTLFKKICDGIFY---------------TPQYL---NPSVISLLKHMLQVDPMKRA 276 Query: 341 TMDQVVRA 348 T+ + Sbjct: 277 TIKDIREH 284 >1K9A-A nrPDB Length = 450 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 78/308 (25%), Positives = 128/308 (41%), Gaps = 39/308 (12%) Query: 52 VKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEG 111 F + L + + IG+G FG V G G +AVK + + Sbjct: 180 QDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR-----------GNKVAVKCIKNDA 228 Query: 112 FQGHREWLTEINYLGQLSHPNLVKLIGYCLED-EHRLLVYEFMQKGSLENHLFRRGAYFK 170 + +L E + + QL H NLV+L+G +E+ +V E+M KGSL ++L RG Sbjct: 229 T--AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRS-- 284 Query: 171 PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMG 230 L + +LD + + +L + ++RD+ A N+L+ D AK+SDFGL ++ Sbjct: 285 VLGGDCLLKFSLDVCEAMEYL--EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA--- 339 Query: 231 DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENL 290 S + APE + + +SDV+SFG+LL EI S R P K+ Sbjct: 340 --SSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD--- 394 Query: 291 VDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQ 350 V+ V+ + V C + +RPT Q+ L+ Sbjct: 395 -------------VVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLE 441 Query: 351 QLQDNLGK 358 ++ + Sbjct: 442 HIRTHELH 449 >1BYG-A nrPDB Length = 278 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 77/308 (25%), Positives = 127/308 (41%), Gaps = 39/308 (12%) Query: 52 VKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEG 111 F + L + + IG+G FG V G G +AVK + + Sbjct: 8 QDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYR-----------GNKVAVKCIKNDA 56 Query: 112 FQGHREWLTEINYLGQLSHPNLVKLIGYCLED-EHRLLVYEFMQKGSLENHLFRRGAYFK 170 + +L E + + QL H NLV+L+G +E+ +V E+M KGSL ++L RG Sbjct: 57 T--AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRS-- 112 Query: 171 PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMG 230 L + +LD + + +L + ++RD+ A N+L+ D AK+SDFGL ++ Sbjct: 113 VLGGDCLLKFSLDVCEAMEYL--EGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA--- 167 Query: 231 DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENL 290 S + APE + + +SDV+SFG+LL EI S R P K+ Sbjct: 168 --SSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD--- 222 Query: 291 VDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQ 350 V+ V+ + V C + RP+ Q+ L+ Sbjct: 223 -------------VVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLE 269 Query: 351 QLQDNLGK 358 ++ + Sbjct: 270 HIKTHELH 277 >2XIK-A nrPDB Length = 294 Score = 233 bits (595), Expect = 7e-62, Method: Composition-based stats. Identities = 69/287 (24%), Positives = 120/287 (41%), Gaps = 36/287 (12%) Query: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN-QEGFQGHREWLTE 121 F IG+G FG V+KG T V+A+K ++ +E + E Sbjct: 17 PEELFTKLDRIGKGSFGEVYKG---------IDNHTKEVVAIKIIDLEEAEDEIEDIQQE 67 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 I L Q P + + G L+ ++ E++ GS + L PL + Sbjct: 68 ITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK-----PGPLEETYIATIL 122 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 + KGL +LHS+ I+RDIKA+N+LL + KL+DFG+A G + D +G Sbjct: 123 REILKGLDYLHSERK--IHRDIKAANVLLSEQGDVKLADFGVA--GQLTDTQIKRNTFVG 178 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK 301 T + APE + + ++D++S G+ +E+ G+ P Sbjct: 179 TPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPM---------------- 222 Query: 302 RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 +VL ++ + + CL+ +P+ RPT ++++ Sbjct: 223 -RVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKH 268 >6E9W-A nrPDB Length = 443 Score = 233 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 70/317 (22%), Positives = 120/317 (37%), Gaps = 37/317 (11%) Query: 6 SSRVKADIFHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATR 65 S V +D +G + +Y L + + + + LS +L++ Sbjct: 50 KSEVNSDCLLDGLDALVYDLDFPALRKNKNID-------NFLSRYKDTINKIRDLRMKAE 102 Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE---WLTEI 122 ++ VIG G FG V T V A+K L++ + + E Sbjct: 103 DYEVVKVIGRGAFGEV---------QLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEER 153 Query: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 + + + P +V+L +D + +V E+M G L N + +P Sbjct: 154 DIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-----DVPEKWARFYTA 208 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 + L +HS + I+RD+K N+LLD + KL+DFG + T +GT Sbjct: 209 EVVLALDAIHS--MGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDT-AVGT 265 Query: 243 YGYAAPEYMSS----GHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 Y +PE + S G+ D +S GV L E+L G ++LV + Sbjct: 266 PDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPF------YADSLVGTYSKIM 319 Query: 299 TSKRKVLLIVDNRLDTQ 315 K + DN + + Sbjct: 320 NHKNSLTFPDDNDISKE 336 >4HVI-A nrPDB Length = 314 Score = 233 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 77/293 (26%), Positives = 131/293 (44%), Gaps = 17/293 (5%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEIN 123 R+ + S +G+G FG V D P TG ++AVK+L G R++ EI Sbjct: 9 ERHLKYISQLGKGNFGSVELCRYD-----PLGDNTGALVAVKQLQHSGPDQQRDFQREIQ 63 Query: 124 YLGQLSHPNLVKLIGYCLEDEH--RLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 L L +VK G LV E++ G L + L R A L + + Sbjct: 64 ILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR---LDASRLLLYS 120 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 KG+ +L S + ++RD+ A NIL++++ + K++DFGLA+ P+ D Y R G Sbjct: 121 SQICKGMEYLGSR--RCVHRDLAARNILVESEAHVKIADFGLAKLLPL-DKDYYVVREPG 177 Query: 242 --TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLT 299 + APE +S + +SDV+SFGV+L E+ + P+ E + + + Sbjct: 178 QSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCD--KSCSPSAEFLRMMGSERDVP 235 Query: 300 SKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 + ++L +++ P + + C + P+ RP+ + L L Sbjct: 236 ALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDML 288 >5HIE-A nrPDB Length = 302 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 70/304 (23%), Positives = 136/304 (44%), Gaps = 36/304 (11%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 ++ ++ IG G FG V+KG +AVK L + Q Sbjct: 29 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD------------VAVKMLTPQQLQA--- 73 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 + E+ L + H N++ +GY + + +V ++ + SL +HL F+ + Sbjct: 74 FKNEVGVLRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLYHHLHIIETKFEMIK---L 129 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 +++A A+G+ +LH+ +I+RD+K++NI L D K+ DFGLA S+ Sbjct: 130 IDIARQTAQGMDYLHAKS--IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFE 187 Query: 238 RVMGTYGYAAPEYMS---SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWA 294 ++ G+ + APE + + +SDVY+FG++L E+++G+ + +++ + Sbjct: 188 QLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN-NRDQIIFMVG 246 Query: 295 RPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQD 354 R YL+ + M + +CL + RP Q++ +++ L Sbjct: 247 RGYLSPDLS-----------KVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLAR 295 Query: 355 NLGK 358 +L K Sbjct: 296 SLPK 299 >5ES1-A nrPDB Length = 328 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 66/286 (23%), Positives = 118/286 (41%), Gaps = 39/286 (13%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF--QGHREWLTEIN 123 N+R IG+G F V TG +A+K +++ ++ E+ Sbjct: 16 NYRLLRTIGKGNFAKVKLA---------RHILTGREVAIKIIDKTQLNPSSLQKLFREVR 66 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 + L+HPN+VKL ++ LV E+ G + ++L G + Sbjct: 67 IMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAK----FRQ 122 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 + + H +++RD+KA N+LLDA+ N K++DFG + + +G G+ Sbjct: 123 IVSAVHYCHQK--NIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGS---KLDTFCGSP 177 Query: 244 GYAAPEYMSSGHLN-ARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 YAAPE + D++S GV+L ++SG D + NL + L K Sbjct: 178 PYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGH------NLKELRERVLRGKY 231 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 +V + + S+ + L P R T++Q+++ Sbjct: 232 RVPFYMSTDCE------------SILRRFLVLNPAKRCTLEQIMKD 265 >2BPM-A nrPDB Length = 309 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 74/301 (24%), Positives = 128/301 (42%), Gaps = 30/301 (9%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG--HREWL 119 + NF+ IGEG +G V+K TG V+A+KK+ + + Sbjct: 4 VDMENFQKVEKIGEGTYGVVYKA---------RNKLTGEVVALKKIRLDTETEGVPSTAI 54 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 EI+ L +L+HPN+VKL+ + LV+EF+ L+ + PLP L + Sbjct: 55 REISLLKELNHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLP--LIKS 111 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 +GLAF HS +V++RD+K N+L++ + KL+DFGLAR + +Y T Sbjct: 112 YLFQLLQGLAFCHSH--RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTY--THE 167 Query: 240 MGTYGYAAPEYMSS-GHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEE--------NL 290 + T Y APE + + + D++S G + E+++ + + + Sbjct: 168 VVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTP 227 Query: 291 VDWARPYLTSKRKVLLIVDNRLDTQY---LPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 + P +TS + +P S+ Q L ++P R + + Sbjct: 228 DEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA 287 Query: 348 A 348 Sbjct: 288 H 288 >5GRN-A nrPDB Length = 356 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 68/320 (21%), Positives = 116/320 (36%), Gaps = 47/320 (14%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 + + V+G G FG V +G + ++ + +AVK L ++ Sbjct: 39 SRWEFPRDGLVLGRVLGSGAFGKVVEG----TAYGLSRSQPVMKVAVKMLKPTARSSEKQ 94 Query: 118 WLT-EINYLGQLS-HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF------ 169 L E+ + L H N+V L+G C + ++ E+ G L N+L + F Sbjct: 95 ALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKK 154 Query: 170 ----------------KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD 213 + L ++ A+G+ FL S ++RD+ A N+LL Sbjct: 155 SMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASK--NCVHRDLAARNVLLAQG 212 Query: 214 YNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEIL 273 K+ DFGLARD + APE + SDV+S+G+LL EI Sbjct: 213 KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF 272 Query: 274 S-GKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCL 332 S G P + + + + + V+C Sbjct: 273 SLGGTPY----------------PGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCW 316 Query: 333 SFEPKSRPTMDQVVRALQQL 352 + EP+ RP+ + ++ L Sbjct: 317 NSEPEKRPSFYHLSEIVENL 336 >5GNK-A nrPDB Length = 297 Score = 231 bits (589), Expect = 5e-61, Method: Composition-based stats. Identities = 60/296 (20%), Positives = 130/296 (43%), Gaps = 30/296 (10%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ-EGFQGHREWLT 120 L F+ V+G G FG V+KG P + +A+K+L + + ++E L Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGL-----WIPEGEKVKIPVAIKELREATSPKANKEILD 70 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 E + + +P++ +L+G CL + L+ + M G L +++ + +N Sbjct: 71 EAYVMASVDNPHVCRLLGICLTSTVQ-LIMQLMPFGCLLDYVREHKDN---IGSQYLLNW 126 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 + AKG+ +L + ++++RD+ A N+L+ + K++DFGLA+ + Y + Sbjct: 127 CVQIAKGMNYL--EDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGK 184 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLT 299 + A E + +SDV+S+GV + E+++ G + D ++ ++++ Sbjct: 185 VPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGE---- 240 Query: 300 SKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 P + + + V+C + SRP +++ ++ + Sbjct: 241 -------------RLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARD 283 >5HI2-A nrPDB Length = 283 Score = 231 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 69/303 (22%), Positives = 135/303 (44%), Gaps = 36/303 (11%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 ++ ++ IG G FG V+KG +AVK L + Q Sbjct: 13 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD------------VAVKMLTPQQLQA--- 57 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 + E+ L + H N++ +GY + + +V ++ + SL +HL F+ Sbjct: 58 FKNEVGVLRKTRHVNILLFMGYSTKPQ-LAIVTQWCEGSSLYHHLHASETKFE---MKKL 113 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 +++A A+G+ +LH+ +I+RD+K++NI L D K+ DFGLA S+ Sbjct: 114 IDIARQTARGMDYLHAKS--IIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFE 171 Query: 238 RVMGTYGYAAPEYMS---SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWA 294 ++ G+ + APE + S + +SDVY+FG++L E+++G+ + +++ + Sbjct: 172 QLSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNIN-NRDQIIEMVG 230 Query: 295 RPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQD 354 R L+ + RM + +CL + RP+ +++ +++L Sbjct: 231 RGSLSPDLS-----------KVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAR 279 Query: 355 NLG 357 L Sbjct: 280 ELS 282 >5KZ7-A nrPDB Length = 346 Score = 231 bits (588), Expect = 6e-61, Method: Composition-based stats. Identities = 67/286 (23%), Positives = 118/286 (41%), Gaps = 39/286 (13%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH--REWLTEIN 123 N+R IG+G F V TG +AVK +++ ++ E+ Sbjct: 34 NYRLLKTIGKGNFAKVKLA---------RHILTGKEVAVKIIDKTQLNSSSLQKLFREVR 84 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 + L+HPN+VKL ++ LV E+ G + ++L G + Sbjct: 85 IMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAK----FRQ 140 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 + + H +++RD+KA N+LLDAD N K++DFG + + G+ G+ Sbjct: 141 IVSAVQYCHQKF--IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGN---KLDTFCGSP 195 Query: 244 GYAAPEYMSSGHLN-ARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 YAAPE + DV+S GV+L ++SG D +NL + L K Sbjct: 196 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG------QNLKELRERVLRGKY 249 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 ++ + + ++ + L P R T++Q+++ Sbjct: 250 RIPFYMSTDCE------------NLLKKFLILNPSKRGTLEQIMKD 283 >3QUP-A nrPDB Length = 323 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 77/319 (24%), Positives = 132/319 (41%), Gaps = 36/319 (11%) Query: 56 TFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE--GFQ 113 ++ + + F ++G+G FG V + L + + G+ + +AVK L + Sbjct: 14 KLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQ------EDGSFVKVAVKMLKADIIASS 67 Query: 114 GHREWLTEINYLGQLSHPNLVKLIGYCLEDEHR------LLVYEFMQKGSLENHLF--RR 165 E+L E + + HP++ KL+G L + +++ FM+ G L L R Sbjct: 68 DIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRI 127 Query: 166 GAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR 225 G LP V +D A G+ +L S I+RD+ A N +L D ++DFGL+R Sbjct: 128 GENPFNLPLQTLVRFMVDIACGMEYLSSR--NFIHRDLAARNCMLAEDMTVCVADFGLSR 185 Query: 226 DGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRP 284 GD + A E ++ SDV++FGV + EI++ G+ Sbjct: 186 KIYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIEN 245 Query: 285 AKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQ 344 A+ N YL ++ PE + + QC S +PK RP+ Sbjct: 246 AEIYN-------YLIGGNRLKQ----------PPECMEEVYDLMYQCWSADPKQRPSFTC 288 Query: 345 VVRALQQLQDNLGKPSQTN 363 + L+ + +L S + Sbjct: 289 LRMELENILGHLSVLSTSQ 307 >5EZV-A nrPDB Length = 560 Score = 230 bits (587), Expect = 7e-61, Method: Composition-based stats. Identities = 69/296 (23%), Positives = 118/296 (39%), Gaps = 42/296 (14%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR- 116 ++ ++ ++ +G G FG V G TG +AVK LN++ + Sbjct: 21 HDGRVKIGHYVLGDTLGVGTFGKVKIG---------EHQLTGHKVAVKILNRQKIRSLDV 71 Query: 117 --EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPW 174 + EI L HP+++KL +V E++ G L +++ + G + Sbjct: 72 VGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEE---- 127 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSY 234 + + + H V++RD+K N+LLDA NAK++DFGL+ G+ Sbjct: 128 MEARRLFQQILSAVDYCHRHM--VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR 185 Query: 235 VSTRVMGTYGYAAPEYMSSGHL-NARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDW 293 S G+ YAAPE +S D++S GV+L +L G D + Sbjct: 186 TS---CGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI-- 240 Query: 294 ARPYLTSKRKVLLIVDNRLDTQYLPEEAVR-MASVAVQCLSFEPKSRPTMDQVVRA 348 R Y+PE R +A++ + L +P R T+ + Sbjct: 241 -----------------RGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREH 279 >3LZB-A nrPDB Length = 327 Score = 230 bits (587), Expect = 8e-61, Method: Composition-based stats. Identities = 59/296 (19%), Positives = 129/296 (43%), Gaps = 30/296 (10%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ-EGFQGHREWLT 120 L F+ V+G G FG V+KG P + +A+K+L + + ++E L Sbjct: 12 LKETEFKKIKVLGSGAFGTVYKGL-----WIPEGEKVKIPVAIKELREATSPKANKEILD 66 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 E + + +P++ +L+G CL + L+ + M G L +++ + +N Sbjct: 67 EAYVMASVDNPHVCRLLGICLTSTVQ-LITQLMPFGCLLDYVREHKDN---IGSQYLLNW 122 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 + AKG+ +L + ++++RD+ A N+L+ + K++DFGLA+ + Y + Sbjct: 123 CVQIAKGMNYL--EDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGK 180 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLT 299 + A E + +SDV+S+GV + E+++ G + D ++ ++++ Sbjct: 181 VPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGE---- 236 Query: 300 SKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 P + + + +C + SRP +++ ++ + Sbjct: 237 -------------RLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEFSKMARD 279 >5DBX-A nrPDB Length = 328 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 69/297 (23%), Positives = 123/297 (41%), Gaps = 28/297 (9%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ-GHREW 118 + + VIG G V +A+K++N E Q E Sbjct: 6 WPICRDAYELQEVIGSGATAVVQAALCKPRQ---------ERVAIKRINLEKCQTSMDEL 56 Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLEN---HLFRRGAYFK-PLPW 174 L EI + Q SHPN+V + + LV + + GS+ + ++ RG + L Sbjct: 57 LKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEE 116 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMG---D 231 + + + +GL +LH + I+RD+KA NILL D + +++DFG++ G Sbjct: 117 AIIATILKEVLEGLDYLHRN--GQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVT 174 Query: 232 LSYVSTRVMGTYGYAAPEYMSS-GHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENL 290 + V +GT + APE M + ++D++SFG+ +E+ +G P K Sbjct: 175 RNKVRKDFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVL-- 232 Query: 291 VDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 LT + + D + + + + CL +P RPT ++++ Sbjct: 233 ------MLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLK 283 >2YZA-A nrPDB Length = 276 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 69/298 (23%), Positives = 119/298 (39%), Gaps = 42/298 (14%) Query: 56 TFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH 115 + ++ ++ ++ +G G FG V G TG +AVK LN++ + Sbjct: 2 SKHDGRVKIGHYVLGDTLGVGTFGKVKIG---------EHQLTGHKVAVKILNRQKIRSL 52 Query: 116 R---EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPL 172 + EI L HP+++KL +V E++ G L +++ + G + Sbjct: 53 DVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEE-- 110 Query: 173 PWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDL 232 + + + H V++RD+K N+LLDA NAK++DFGL+ G+ Sbjct: 111 --MEARRLFQQILSAVDYCHRHM--VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF 166 Query: 233 SYVSTRVMGTYGYAAPEYMSSGHL-NARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 S G+ YAAPE +S D++S GV+L +L G D + Sbjct: 167 LRDS---CGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKI 223 Query: 292 DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVR-MASVAVQCLSFEPKSRPTMDQVVRA 348 R Y+PE R +A++ + L +P R T+ + Sbjct: 224 -------------------RGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREH 262 >5VO2-A nrPDB Length = 300 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 73/304 (24%), Positives = 128/304 (42%), Gaps = 44/304 (14%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL 119 ++ +G G G VF G G +AVKK+ Sbjct: 7 WEVPFEEILDLQWVGSGAQGAVFLGRFH-----------GEEVAVKKVRDLKE------- 48 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 T+I +L +L HPN++ G C + ++ EF +G L L +P+ L V+ Sbjct: 49 TDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA----GRPVTPSLLVD 104 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 ++ A G+ +LH K+I+RD+K+ N+L+ D K+SDFG +++ Sbjct: 105 WSMGIAGGMNYLHLH--KIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKST---KMSF 159 Query: 240 MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLT 299 GT + APE + + ++ + D++SFGV+L E+L+G+ + Sbjct: 160 AGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKD----------------VD 203 Query: 300 SKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQ-QLQDNLGK 358 S + + N L + QC + +P++RP+ Q++ L D L Sbjct: 204 SSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLST 263 Query: 359 PSQT 362 P +T Sbjct: 264 PQET 267 >4MVF-A nrPDB Length = 506 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 65/334 (19%), Positives = 131/334 (39%), Gaps = 38/334 (11%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEIN 123 + D +G+G +GCV+KG T + A+K+ ++ + + EI Sbjct: 56 EDKYIIDEKLGQGTYGCVYKG---------IDKVTNQLYAIKEEKKDRLKNINRFFQEIE 106 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 + +L HPN+VKL D + L+ E L + + G++ + + Sbjct: 107 IMKKLDHPNIVKLYETYENDNYIYLIMELCSGRELFDSIIENGSFTEK----NAATIMKQ 162 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILL---DADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 + +LHS + +++RD+K N L + D K+ DFGL+++ G+ + T Sbjct: 163 IFSAIFYLHS--LNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFT---TTKA 217 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 GT Y AP+ + G + + D++S GV++ +L G + + V Sbjct: 218 GTPYYVAPQVL-DGKYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYE 276 Query: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPS 360 + D + ++ + L++ P R T+++ + + K Sbjct: 277 NDWGSISSDAK--------------NLITKLLTYNPNERCTIEEALNH--PWITQMTKSH 320 Query: 361 QTNPVKDTKKLGFKTGTTKSSEKRFTQKPFGRHL 394 + + T K ++ K+ +HL Sbjct: 321 EHVELSSTLLKNLKNFKKENELKKIALTIIAKHL 354 >2QNJ-A nrPDB Length = 328 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 66/307 (21%), Positives = 126/307 (41%), Gaps = 41/307 (13%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ--GHREWLTEIN 123 N+R IG+G F V TG +A+K +++ ++ E+ Sbjct: 13 NYRLLKTIGKGNFAKVKLA---------RHILTGREVAIKIIDKTQLNPTSLQKLFREVR 63 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 + L+HPN+VKL ++ L+ E+ G + ++L G + Sbjct: 64 IMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSK----FRQ 119 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 + + H ++++RD+KA N+LLDAD N K++DFG + + +G G+ Sbjct: 120 IVSAVQYCHQK--RIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGG---KLDTFCGSP 174 Query: 244 GYAAPEYMSSGHLN-ARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 YAAPE + DV+S GV+L ++SG D +NL + L K Sbjct: 175 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG------QNLKELRERVLRGKY 228 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQT 362 ++ + + ++ + L P R T++Q+++ + + + + Sbjct: 229 RIPFYMSTDCE------------NLLKRFLVLNPIKRGTLEQIMK--DRWINAGHEEDEL 274 Query: 363 NPVKDTK 369 P + + Sbjct: 275 KPFVEPE 281 >4Y93-A nrPDB Length = 446 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 71/334 (21%), Positives = 133/334 (39%), Gaps = 42/334 (12%) Query: 24 GLSLSSRKSSSTVAAAQKTEGEILSSTPVKS-FTFNELKLATRNFRPDSVIGEGGFGCVF 82 G L +++ Q IL++ P + + ++ ++ +G G FG V Sbjct: 151 GQYLCCSQTAKNAMGCQ-----ILAAAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVK 205 Query: 83 KGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLE 142 G +A+K + +EG E++ E + LSH LV+L G C + Sbjct: 206 YGKWRGQYD----------VAIKMI-KEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTK 254 Query: 143 DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRD 202 ++ E+M G L N+L F+ + + D + + +L S ++RD Sbjct: 255 QRPIFIITEYMANGCLLNYLREMRHRFQT---QQLLEMCKDVCEAMEYLESKQ--FLHRD 309 Query: 203 IKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDV 262 + A N L++ K+SDFG+ R + D ST +A+PE + +++SD+ Sbjct: 310 LAARNCLVNDQGVVKVSDFGMTRYV-LDDEYTSSTGSKFPVKWASPEVLMYSKFSSKSDI 368 Query: 263 YSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEA 321 ++FGVL+ EI S GK + + + + L + Sbjct: 369 WAFGVLMWEIYSLGKMPYE-----------------RFTNSETAEHIAQGLRLPRPHLAS 411 Query: 322 VRMASVAVQCLSFEPKSRPTMDQVVR-ALQQLQD 354 R+ ++ C + RPT ++ L + + Sbjct: 412 ERVYAIMYSCWHEKADERPTFKILLSNILDVMDE 445 >2WQN-A nrPDB Length = 310 Score = 228 bits (581), Expect = 4e-60, Method: Composition-based stats. Identities = 68/314 (21%), Positives = 128/314 (40%), Gaps = 30/314 (9%) Query: 51 PVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL--- 107 P K+ + NFR + IG G F V++ G+ +A+KK+ Sbjct: 18 PQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLD---------GVPVALKKVQIF 68 Query: 108 NQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGA 167 + + + + EI+ L QL+HPN++K +ED +V E G L + Sbjct: 69 DLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKK 128 Query: 168 YFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG 227 + +P + L +HS +V++RDIK +N+ + A KL D GL R Sbjct: 129 QKRLIPERTVWKYFVQLCSALEHMHSR--RVMHRDIKPANVFITATGVVKLGDLGLGRFF 186 Query: 228 PMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE 287 + + ++GT Y +PE + N +SD++S G LL E+ + + ++ Sbjct: 187 --SSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMN-- 242 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 + +K+ L + + EE + + C++ +P+ RP + V Sbjct: 243 ---------LYSLCKKIEQCDYPPLPSDHYSEE---LRQLVNMCINPDPEKRPDVTYVYD 290 Query: 348 ALQQLQDNLGKPSQ 361 +++ + Sbjct: 291 VAKRMHACTASSLE 304 >1FVR-A nrPDB Length = 327 Score = 228 bits (581), Expect = 4e-60, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 127/305 (41%), Gaps = 44/305 (14%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG-HREWLTEIN 123 + + VIGEG FG V K + + L A+K++ + + HR++ E+ Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDA-------AIKRMKEYASKDDHRDFAGELE 77 Query: 124 YLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKP----------- 171 L +L HPN++ L+G C + L E+ G+L + L + Sbjct: 78 VLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTAS 137 Query: 172 -LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMG 230 L ++ A D A+G+ +L I+RD+ A NIL+ +Y AK++DFGL+R Sbjct: 138 TLSSQQLLHFAADVARGMDYLSQKQ--FIHRDLAARNILVGENYVAKIADFGLSRGQ--- 192 Query: 231 DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEEN 289 ++ T + A E ++ SDV+S+GVLL EI+S G Sbjct: 193 EVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCG-------- 244 Query: 290 LVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRAL 349 + ++ + + + + QC +P RP+ Q++ +L Sbjct: 245 ---------MTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL 295 Query: 350 QQLQD 354 ++ + Sbjct: 296 NRMLE 300 >6DBN-A nrPDB Length = 316 Score = 227 bits (579), Expect = 6e-60, Method: Composition-based stats. Identities = 77/317 (24%), Positives = 130/317 (41%), Gaps = 18/317 (5%) Query: 40 QKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTG 99 ++ + P + R + +GEG FG V D P TG Sbjct: 12 EQNPDIVSEKKPATE--VDPTHFEKRFLKRIRDLGEGHFGKVELCRYD-----PEGDNTG 64 Query: 100 LVIAVKKLNQEGFQGH-REWLTEINYLGQLSHPNLVKLIGYCLED--EHRLLVYEFMQKG 156 +AVK L E H + EI L L H N+VK G C ED L+ EF+ G Sbjct: 65 EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSG 124 Query: 157 SLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA 216 SL+ +L + + ++ A+ KG+ +L S ++RD+ A N+L+++++ Sbjct: 125 SLKEYLPKNKN---KINLKQQLKYAVQICKGMDYLGSRQ--YVHRDLAARNVLVESEHQV 179 Query: 217 KLSDFGLARDGPMGDLSY-VSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 K+ DFGL + Y V + APE + SDV+SFGV L E+L+ Sbjct: 180 KIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTY 239 Query: 276 KRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFE 335 + D + A ++ +T R ++ + P + + +C F+ Sbjct: 240 CDS-DSSPMALFLKMIGPTHGQMTVTR-LVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQ 297 Query: 336 PKSRPTMDQVVRALQQL 352 P +R + ++ + L Sbjct: 298 PSNRTSFQNLIEGFEAL 314 >5U6C-A nrPDB Length = 315 Score = 227 bits (579), Expect = 6e-60, Method: Composition-based stats. Identities = 70/313 (22%), Positives = 130/313 (41%), Gaps = 35/313 (11%) Query: 56 TFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVK--KLNQEGFQ 113 ++ + ++GEG FG V +G L + + GT L +AVK KL+ + Sbjct: 27 KLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQ------EDGTSLKVAVKTMKLDNSSQR 80 Query: 114 GHREWLTEINYLGQLSHPNLVKLIGYCLED-----EHRLLVYEFMQKGSLENHLF--RRG 166 E+L+E + SHPN+++L+G C+E +++ FM+ G L +L R Sbjct: 81 EIEEFLSEAACMKDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLE 140 Query: 167 AYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD 226 K +P + +D A G+ +L ++RD+ A N +L D ++DFGL++ Sbjct: 141 TGPKHIPLQTLLKFMVDIALGMEYL--SNRNFLHRDLAARNCMLRDDMTVCVADFGLSKK 198 Query: 227 GPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPA 285 GD + A E ++ ++SDV++FGV + EI + G Sbjct: 199 IYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPG---- 254 Query: 286 KEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQV 345 ++ + + + + + + C +P RPT + Sbjct: 255 -------------VQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVL 301 Query: 346 VRALQQLQDNLGK 358 L++L ++L Sbjct: 302 RLQLEKLLESLPD 314 >4FZF-B nrPDB Length = 283 Score = 227 bits (578), Expect = 8e-60, Method: Composition-based stats. Identities = 69/290 (23%), Positives = 119/290 (41%), Gaps = 36/290 (12%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN-QEGFQGHREW 118 + F IG+G FG VFKG T V+A+K ++ +E + Sbjct: 3 MADPEELFTKLERIGKGSFGEVFKG---------IDNRTQQVVAIKIIDLEEAEDEIEDI 53 Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 EI L Q + K G L+ ++ E++ GS + L P F Sbjct: 54 QQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-----GPFDEFQIA 108 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR 238 + + KGL +LHS+ I+RDIKA+N+LL + KL+ FG+A G + D Sbjct: 109 TMLKEILKGLDYLHSEKK--IHRDIKAANVLLSEQGDVKLAAFGVA--GQLTDTQIKRNT 164 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 +GT + APE + ++++D++S G+ +E+ G+ P Sbjct: 165 FVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPM------------- 211 Query: 299 TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 +VL ++ + + CL+ +P RPT ++++ Sbjct: 212 ----RVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKH 257 >3PP0-A nrPDB Length = 338 Score = 227 bits (578), Expect = 8e-60, Method: Composition-based stats. Identities = 70/321 (21%), Positives = 137/321 (42%), Gaps = 34/321 (10%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ-EGFQGHREWLT 120 L R V+G G FG V+KG P + +A+K L + + ++E L Sbjct: 14 LKETELRKVKVLGSGAFGTVYKG-----IWIPDGENVKIPVAIKVLRENTSPKANKEILD 68 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 E + + P + +L+G CL + LV + M G L +H+ L +N Sbjct: 69 EAYVMAGVGSPYVSRLLGICLTSTVQ-LVTQLMPYGCLLDHVRENRGR---LGSQDLLNW 124 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 + AKG+++L + V++++RD+ A N+L+ + + K++DFGLAR + + Y + Sbjct: 125 CMQIAKGMSYL--EDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGK 182 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLT 299 + A E + +SDV+S+GV + E+++ G + D Sbjct: 183 VPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIP---------------- 226 Query: 300 SKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKP 359 R++ +++ P + + + V+C + + RP ++V ++ + Sbjct: 227 -AREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDP--- 282 Query: 360 SQTNPVKDTKKLGFKTGTTKS 380 Q V + LG + + Sbjct: 283 -QRFVVIQNEDLGPASPLDST 302 >4REW-A nrPDB Length = 540 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 68/292 (23%), Positives = 114/292 (39%), Gaps = 40/292 (13%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR---E 117 + ++ +G G FG V G + TG +AVK LN++ + + Sbjct: 2 SVKIGHYILGDTLGVGTFGKVKVGKHE---------LTGHKVAVKILNRQKIRSLDVVGK 52 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 EI L HP+++KL +V E++ G L +++ + G + Sbjct: 53 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESR--- 109 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 + G+ + H V++RD+K N+LLDA NAK++DFGL+ G+ S Sbjct: 110 -RLFQQILSGVDYCHRHM--VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS- 165 Query: 238 RVMGTYGYAAPEYMSSGHL-NARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 G+ YAAPE +S D++S GV+L +L G D + + Sbjct: 166 --CGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIF 223 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 Y QYL + S+ L +P R ++ + Sbjct: 224 Y---------------TPQYL---NPSVISLLKHMLQVDPMKRASIKDIREH 257 >2JDO-A nrPDB Length = 342 Score = 226 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 72/298 (24%), Positives = 116/298 (38%), Gaps = 43/298 (14%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW 118 + K+ +F ++G+G FG V + + TG A+K L +E E Sbjct: 4 DPKVTMNDFDYLKLLGKGTFGKV---------ILVREKATGRYYAMKILRKEVIIAKDEV 54 Query: 119 ---LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 +TE L HP L L + V E+ G L HL R + + F Sbjct: 55 AHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARF 114 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 + L +LHS V+YRDIK N++LD D + K++DFGL ++G + Sbjct: 115 YGA----EIVSALEYLHSRD--VVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGAT-- 166 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 GT Y APE + D + GV++ E++ G+ + + L+ Sbjct: 167 MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELI---- 222 Query: 296 PYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSR----PT-MDQVVRA 348 L+ + R PE +A + L +PK R P+ +V+ Sbjct: 223 ----------LMEEIRFPRTLSPEAKSLLAGL----LKKDPKQRLGGGPSDAKEVMEH 266 >4HZS-A nrPDB Length = 341 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 76/298 (25%), Positives = 131/298 (43%), Gaps = 35/298 (11%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF---QGHREW 118 + ++ R +G+G FG V +G D + G + +AVK L + + ++ Sbjct: 9 IGEKDLRLLEKLGDGSFGVVRRGEWDAPS------GKTVSVAVKCLKPDVLSQPEAMDDF 62 Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 + E+N + L H NL++L G L + +V E GSL + L + +F Sbjct: 63 IREVNAMHSLDHRNLIRLYGVVLTPPMK-MVTELAPLGSLLDRLRKHQGHFL---LGTLS 118 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV-ST 237 A+ A+G+ +L S + I+RD+ A N+LL K+ DFGL R P D YV Sbjct: 119 RYAVQVAEGMGYLESK--RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQE 176 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARP 296 + + APE + + + SD + FGV L E+ + G+ Sbjct: 177 HRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIG--------------- 221 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEEAVR-MASVAVQCLSFEPKSRPTMDQVVRALQQLQ 353 + ++L +D + PE+ + + +V VQC + +P+ RPT + L + Q Sbjct: 222 --LNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQ 277 >1U54-B nrPDB Length = 291 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 79/311 (25%), Positives = 136/311 (43%), Gaps = 38/311 (12%) Query: 49 STPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN 108 P++S T + ++ R +G+G FG V +G D + G + +AVK L Sbjct: 5 EGPLQSLT---CLIGEKDLRLLEKLGDGSFGVVRRGEWDAPS------GKTVSVAVKCLK 55 Query: 109 QEGF---QGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR 165 + + +++ E+N + L H NL++L G L + +V E GSL + L + Sbjct: 56 PDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMK-MVTELAPLGSLLDRLRKH 114 Query: 166 GAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR 225 +F A+ A+G+ +L S + I+RD+ A N+LL K+ DFGL R Sbjct: 115 QGHFL---LGTLSRYAVQVAEGMGYLESK--RFIHRDLAARNLLLATRDLVKIGDFGLMR 169 Query: 226 DGPMGDLSYV-STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNR 283 P D YV + + APE + + + SD + FGV L E+ + G+ Sbjct: 170 ALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIG-- 227 Query: 284 PAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVR-MASVAVQCLSFEPKSRPTM 342 + ++L +D + PE+ + + +V VQC + +P+ RPT Sbjct: 228 ---------------LNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTF 272 Query: 343 DQVVRALQQLQ 353 + L + Q Sbjct: 273 VALRDFLLEAQ 283 >6BFN-A nrPDB Length = 342 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 106/344 (30%), Positives = 155/344 (45%), Gaps = 47/344 (13%) Query: 46 ILSSTPVK-SFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAV 104 + S P + E+ T NF + IGEGGFGCV++ + + V AV Sbjct: 2 AMGSRPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNT-----------VYAV 50 Query: 105 KKLNQ----EGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLEN 160 K+L + E + +LTE+ L + HPN+V GYC ++ LVY F+ GSLE+ Sbjct: 51 KRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLED 110 Query: 161 HLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSD 220 L + PL W R+++ L A+ + FLH D +I+ DIK+SN+LLD KL D Sbjct: 111 RLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGD 170 Query: 221 FGLARDGPMGDLS-------YVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEIL 273 FGLAR S + V GT Y EY+ +G L +D +SFGV++LE L Sbjct: 171 FGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETL 230 Query: 274 SGKRALDHNRP---------------------AKEENLVDWARPYLTSKRKVLLIVDNRL 312 +G+RA+ + + + L + + I L Sbjct: 231 AGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHL 290 Query: 313 DT---QYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQ 353 D PE + + +A CL K RP M QV L++LQ Sbjct: 291 DPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQ 334 >4RED-A nrPDB Length = 351 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 68/292 (23%), Positives = 114/292 (39%), Gaps = 40/292 (13%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR---E 117 + ++ +G G FG V G + TG +AVK LN++ + + Sbjct: 10 SVKIGHYILGDTLGVGTFGKVKVGKHE---------LTGHAVAVKILNRQKIRSLDVVGK 60 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 EI L HP+++KL +V E++ G L +++ + G + Sbjct: 61 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESR--- 117 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 + G+ + H V++RD+K N+LLDA NAK++DFGL+ G+ S Sbjct: 118 -RLFQQILSGVDYCHRHM--VVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTS- 173 Query: 238 RVMGTYGYAAPEYMSSGHL-NARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 G+ YAAPE +S D++S GV+L +L G D + + Sbjct: 174 --CGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIF 231 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 Y QYL + S+ L +P R ++ + Sbjct: 232 Y---------------TPQYL---NPSVISLLKHMLQVDPMKRASIKDIREH 265 >6E4F-A nrPDB Length = 290 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 63/298 (21%), Positives = 119/298 (39%), Gaps = 36/298 (12%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW 118 ++ ++ +G G FG V G +A+K + +EG E+ Sbjct: 25 SWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYD----------VAIKMI-KEGSMSEDEF 73 Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 + E + LSH LV+L G C + ++ E+M G L N+L F+ + Sbjct: 74 IEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQT---QQLL 130 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR 238 + D + + +L S ++RD+ A N L++ K+SDFGL+R + D S Sbjct: 131 EMCKDVCEAMEYLESKQ--FLHRDLAARNCLVNDQGVVKVSDFGLSRYV-LDDEYTSSVG 187 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPY 297 ++ PE + +++SD+++FGVL+ EI S GK + Sbjct: 188 SKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYE----------------- 230 Query: 298 LTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR-ALQQLQD 354 + + + L + ++ ++ C + RPT ++ L + + Sbjct: 231 RFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDE 288 >2F57-A nrPDB Length = 317 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 70/301 (23%), Positives = 123/301 (40%), Gaps = 35/301 (11%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 IGEG G V T+ TG +AVKK++ Q E+ + H Sbjct: 52 KIGEGSTGIVCIA---------TEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHD 102 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 N+V + L + +V EF++ G+L + + + + V L + L++L Sbjct: 103 NVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA-----TVCLSVLRALSYL 157 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM 251 H+ VI+RDIK+ +ILL +D KLSDFG + ++GT + APE + Sbjct: 158 HNQ--GVIHRDIKSDSILLTSDGRIKLSDFGFC--AQVSKEVPKRKSLVGTPYWMAPEVI 213 Query: 252 SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNR 311 S D++S G++++E++ G+ + P L + R++ + R Sbjct: 214 SRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPP-------------LQAMRRIRDSLPPR 260 Query: 312 LDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVKDTKKL 371 + L + + + L EP R T +++ G PS P+ + Sbjct: 261 VKD--LHKVSSVLRGFLDLMLVREPSQRATAQELLGH--PFLKLAGPPSCIVPLMRQYRH 316 Query: 372 G 372 Sbjct: 317 H 317 >4LRM-A nrPDB Length = 334 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 60/299 (20%), Positives = 130/299 (43%), Gaps = 33/299 (11%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ-EGFQGHREWLT 120 L F+ V+G G FG V+KG P + +A+K+L + + ++E L Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGL-----WIPEGEKVKIPVAIKELREATSPKANKEILD 70 Query: 121 EINYLGQLSHP---NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 E + + +P ++ +L+G CL + L+ + M G L +++ + Sbjct: 71 EAYVMASVDNPGNPHVCRLLGICLTSTVQ-LITQLMPFGCLLDYVREHKDN---IGSQYL 126 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 +N + AKG+ +L + ++++RD+ A N+L+ + K++DFGLA+ + Y + Sbjct: 127 LNWCVQIAKGMNYL--EDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE 184 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARP 296 + A E + +SDV+S+GV + E+++ G + D ++ ++++ Sbjct: 185 GGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGE- 243 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 P + + + V+C + SRP +++ ++ + Sbjct: 244 ----------------RLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARD 286 >3MV5-A nrPDB Length = 342 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 69/298 (23%), Positives = 115/298 (38%), Gaps = 42/298 (14%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW 118 + ++ F ++G+G FG V + + TG A+K L +E E Sbjct: 4 DPRVTMNEFEYLKLLGKGTFGKV---------ILVKEKATGRYYAMKILKKEVIVAKDEV 54 Query: 119 ---LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 LTE L HP L L + V E+ G L HL R + + F Sbjct: 55 AHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARF 114 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 + L +LHS+ V+YRD+K N++LD D + K++DFGL ++G + Sbjct: 115 YGA----EIVSALDYLHSEK-NVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGAT-- 167 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 GT Y APE + D + GV++ E++ G+ + K L+ Sbjct: 168 MKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI---- 223 Query: 296 PYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP-----TMDQVVRA 348 L+ + R PE ++ + L +PK R ++++ Sbjct: 224 ----------LMEEIRFPRTLGPEAKSLLSGL----LKKDPKQRLGGGSEDAKEIMQH 267 >4XI2-A nrPDB Length = 446 Score = 224 bits (570), Expect = 6e-59, Method: Composition-based stats. Identities = 63/298 (21%), Positives = 118/298 (39%), Gaps = 36/298 (12%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW 118 ++ ++ +G G FG V G +A+K + EG E+ Sbjct: 181 SWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYD----------VAIKMIR-EGSMSEDEF 229 Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 + E + LSH LV+L G C + ++ E+M G L N+L F+ + Sbjct: 230 IEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQT---QQLL 286 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR 238 + D + + +L S ++RD+ A N L++ K+SDFGL+R + D S Sbjct: 287 EMCKDVCEAMEYLESKQ--FLHRDLAARNCLVNDQGVVKVSDFGLSRYV-LDDEYTSSVG 343 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPY 297 ++ PE + +++SD+++FGVL+ EI S GK + Sbjct: 344 SKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYE----------------- 386 Query: 298 LTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR-ALQQLQD 354 + + + L + R+ ++ C + RP+ ++ L + + Sbjct: 387 RFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADERPSFKILLSNILDVMDE 444 >3NIZ-A nrPDB Length = 311 Score = 224 bits (570), Expect = 6e-59, Method: Composition-based stats. Identities = 71/315 (22%), Positives = 133/315 (42%), Gaps = 36/315 (11%) Query: 49 STPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN 108 S+ ++ F L ++ +GEG +G V+K K G ++A+K++ Sbjct: 8 SSGRENLYFQGL---MEKYQKLEKVGEGTYGVVYKA----------KDSQGRIVALKRIR 54 Query: 109 QEGFQG--HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRG 166 + + EI+ L +L HPN+V LI + LV+EFM+K L+ L Sbjct: 55 LDAEDEGIPSTAIREISLLKELHHPNIVSLIDVIHSERCLTLVFEFMEK-DLKKVLDENK 113 Query: 167 AYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD 226 + +G+A H ++++RD+K N+L+++D KL+DFGLAR Sbjct: 114 TGLQD---SQIKIYLYQLLRGVAHCHQH--RILHRDLKPQNLLINSDGALKLADFGLARA 168 Query: 227 GPMGDLSYVSTRVMGTYGYAAPEYMS-SGHLNARSDVYSFGVLLLEILSGKRAL----DH 281 + SY T + T Y AP+ + S + D++S G + E+++GK D Sbjct: 169 FGIPVRSY--THEVVTLWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDD 226 Query: 282 NRPAKEENLVDWARPYLTS--------KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLS 333 ++ K +++ P K++ + + + + +P + L Sbjct: 227 DQLPKIFSILGTPNPREWPQVQELPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLC 286 Query: 334 FEPKSRPTMDQVVRA 348 F+P R + + Sbjct: 287 FDPNKRISARDAMNH 301 >2HAK-A nrPDB Length = 328 Score = 224 bits (570), Expect = 6e-59, Method: Composition-based stats. Identities = 59/270 (21%), Positives = 104/270 (38%), Gaps = 21/270 (7%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ--GHREWLTEIN 123 N+R IG+G F V TG +AVK +++ ++ E+ Sbjct: 16 NYRLQKTIGKGNFAKVKLA---------RHVLTGREVAVKIIDKTQLNPTSLQKLFREVR 66 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 + L+HPN+VKL ++ LV E+ G + ++L G + Sbjct: 67 IMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAK----FRQ 122 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 + + H +++RD+KA N+LLD D N K++DFG + + +G+ G+ Sbjct: 123 IVSAVQYCHQKY--IVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGN---KLDTFCGSP 177 Query: 244 GYAAPEYMSSGHLN-ARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 YAAPE + DV+S GV+L ++SG D + V + + Sbjct: 178 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 237 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCL 332 + P + + + Sbjct: 238 STDCENLLKKLLVLNPIKRGSLEQIMKDRW 267 >5U6B-A nrPDB Length = 307 Score = 224 bits (570), Expect = 7e-59, Method: Composition-based stats. Identities = 70/322 (21%), Positives = 134/322 (41%), Gaps = 39/322 (12%) Query: 56 TFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE--GFQ 113 ++ + +GEG FG V +G L++ + L +AVK + Sbjct: 14 KLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQD-------DSILKVAVKTMKIAICTRS 66 Query: 114 GHREWLTEINYLGQLSHPNLVKLIGYCLEDEHR------LLVYEFMQKGSLENHLFRRGA 167 ++L+E + + HPN+++LIG C + R +++ FM+ G L + L Sbjct: 67 ELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRL 126 Query: 168 YFKP--LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR 225 +P LP + V D A G+ +L + + I+RD+ A N +L+ + + ++DFGL++ Sbjct: 127 GDQPVYLPTQMLVKFMADIASGMEYLSTK--RFIHRDLAARNCMLNENMSVCVADFGLSK 184 Query: 226 DGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRP 284 GD + A E ++ ++SDV+SFGV + EI + G+ Sbjct: 185 KIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVEN 244 Query: 285 AKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQ 344 ++ + YL ++ D + ++ +C P+ RP+ + Sbjct: 245 SEIYD-------YLRQGNRLKQPAD----------CLDGLYALMSRCWELNPQDRPSFTE 287 Query: 345 VVRALQQLQDNLGKPSQTNPVK 366 + L+ L P P + Sbjct: 288 LREDLENTLKAL--PPAQEPDE 307 >3AOX-A nrPDB Length = 344 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 79/323 (24%), Positives = 130/323 (40%), Gaps = 36/323 (11%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ-EGFQGHREWL 119 ++ +N +G G FG V++G + P + L +AVK L + Q ++L Sbjct: 43 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDP----SPLQVAVKTLPEVCSEQDELDFL 98 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFR---RGAYFKPLPWFL 176 E + + +H N+V+ IG L+ R ++ E M G L++ L R + L Sbjct: 99 MEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLD 158 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY---NAKLSDFGLARDGPMGDLS 233 ++VA D A G +L + I+RDI A N LL AK+ DFG+ARD Sbjct: 159 LLHVARDIACGCQYLEEN--HFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYY 216 Query: 234 YVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVD 292 M + PE G +++D +SFGVLL EI S G Sbjct: 217 RKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS----------- 265 Query: 293 WARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 S ++VL V + + + QC +P+ RP ++ ++ Sbjct: 266 ------KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYC 319 Query: 353 QD-----NLGKPSQTNPVKDTKK 370 N P + P+ + ++ Sbjct: 320 TQDPDVINTALPIEYGPLVEEEE 342 >3MN3-A nrPDB Length = 271 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 63/288 (21%), Positives = 115/288 (39%), Gaps = 43/288 (14%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR---EWLTEI 122 N++ +GEG FG V + TG +A+K +N++ EI Sbjct: 5 NYQIVKTLGEGSFGKVKLAY---------HTTTGQKVALKIINKKVLAKSDMQGRIEREI 55 Query: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 +YL L HP+++KL + ++V E+ L +++ +R + Sbjct: 56 SYLRLLRHPHIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDK----MSEQEARRFFQ 110 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 + + H K+++RD+K N+LLD N K++DFGL+ G+ S G+ Sbjct: 111 QIISAVEYCHRH--KIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTS---CGS 165 Query: 243 YGYAAPEYMSSGHL-NARSDVYSFGVLLLEILSGKRALDHNR-PAKEENLVDWARPYLTS 300 YAAPE +S DV+S GV+L +L + D P +N+ + Sbjct: 166 PNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVY----- 220 Query: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + A + + L P +R ++ ++++ Sbjct: 221 --------------TLPKFLSPGAAGLIKRMLIVNPLNRISIHEIMQD 254 >3OMV-A nrPDB Length = 307 Score = 223 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 71/304 (23%), Positives = 133/304 (43%), Gaps = 35/304 (11%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN--QEGFQGHRE 117 ++ + IG G FG V+KG +AVK L + + Sbjct: 31 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD------------VAVKILKVVDPTPEQFQA 78 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 + E+ L + H N++ +GY + ++ +V ++ + SL HL + F+ F Sbjct: 79 FRNEVAVLRKTRHVNILLFMGY-MTKDNLAIVTQWCEGSSLYKHLHVQETKFQ---MFQL 134 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 +++A A+G+ +LH+ +I+RD+K++NI L K+ DFGLA S Sbjct: 135 IDIARQTAQGMDYLHAK--NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVE 192 Query: 238 RVMGTYGYAAPEYMS---SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWA 294 + G+ + APE + + + +SDVYS+G++L E+++G+ H +++ + Sbjct: 193 QPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHIN-NRDQIIFMVG 251 Query: 295 RPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQD 354 R Y L Y M + C+ + RP Q++ +++ LQ Sbjct: 252 RGY----------ASPDLSKLYK-NCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQH 300 Query: 355 NLGK 358 +L K Sbjct: 301 SLPK 304 >3MA6-A nrPDB Length = 298 Score = 223 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 120/300 (40%), Gaps = 39/300 (13%) Query: 55 FTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ- 113 F + + + ++ V+G+G FG V TG AVK +++ + Sbjct: 22 FVQHSTAIFSDRYKGQRVLGKGSFGEVILC---------KDKITGQECAVKVISKRQVKQ 72 Query: 114 --GHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKP 171 L E+ L QL HPN++KL + + + LV E G L + + R + + Sbjct: 73 KTDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSE- 131 Query: 172 LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLARDGP 228 + G+ ++H + K+++RD+K N+LL++ D N ++ DFGL+ Sbjct: 132 ---VDAARIIRQVLSGITYMHKN--KIVHRDLKPENLLLESKSKDANIRIIDFGLSTHF- 185 Query: 229 MGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEE 288 + S +GT Y APE + G + + DV+S GV+L +LSG + Sbjct: 186 --EASKKMKDKIGTAYYIAPEVLH-GTYDEKCDVWSTGVILYILLSGCPPFNGANEYDIL 242 Query: 289 NLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 V+ + + + + + + L++ P R + + Sbjct: 243 KKVEKGKYTF--------------ELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDH 288 >4F0G-A nrPDB Length = 287 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 78/305 (25%), Positives = 138/305 (45%), Gaps = 47/305 (15%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL-------NQEGFQG 114 LA + IG+GGFG V KG L + V+A+K L E + Sbjct: 16 LADNEIEYEKQIGKGGFGLVHKGRLVKD---------KSVVAIKSLILGDSEGETEMIEK 66 Query: 115 HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPW 174 +E+ E+ + L+HPN+VKL G +V EF+ G L + L + P+ W Sbjct: 67 FQEFQREVFIMSNLNHPNIVKLYGLMHNPPR--MVMEFVPCGDLYHRLLDKAH---PIKW 121 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILL-----DADYNAKLSDFGLARDGPM 229 +++ + LD A G+ ++ + +++RD+++ NI L +A AK++DFGL++ Sbjct: 122 SVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ--- 178 Query: 230 GDLSYVSTRVMGTYGYAAPEYM--SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE 287 + + ++G + + APE + ++D YSF ++L IL+G+ D K Sbjct: 179 --SVHSVSGLLGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKI 236 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 + + +I + L + R+ +V C S +PK RP +V+ Sbjct: 237 KFI--------------NMIREEGLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVK 282 Query: 348 ALQQL 352 L +L Sbjct: 283 ELSEL 287 >3PLS-A nrPDB Length = 298 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 76/288 (26%), Positives = 124/288 (43%), Gaps = 33/288 (11%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ-EGFQGHREWLTEINYLGQL 128 D VIG+G FG V+ G + + A+K L++ Q +L E + L Sbjct: 26 DRVIGKGHFGVVYHGEYIDQA------QNRIQCAIKSLSRITEMQQVEAFLREGLLMRGL 79 Query: 129 SHPNLVKLIGYCLEDEHR-LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 +HPN++ LIG L E ++ +M G L + ++ L A+G Sbjct: 80 NHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKD---LISFGLQVARG 136 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR--VMGTYGY 245 + +L K ++RD+ A N +LD + K++DFGLARD + V + Sbjct: 137 MEYLAEQ--KFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKW 194 Query: 246 AAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLTSKRKV 304 A E + + +SDV+SFGVLL E+L+ G H P + +L R++ Sbjct: 195 TALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTH-------FLAQGRRL 247 Query: 305 LLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 +Y P+ + V QC +P RPT +V ++Q+ Sbjct: 248 -------PQPEYCPD---SLYQVMQQCWEADPAVRPTFRVLVGEVEQI 285 >6C9D-A nrPDB Length = 459 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 59/270 (21%), Positives = 104/270 (38%), Gaps = 21/270 (7%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ--GHREWLTEIN 123 N+R IG+G F V TG +AVK +++ ++ E+ Sbjct: 22 NYRLQKTIGKGNFAKVKLA---------RHVLTGREVAVKIIDKTQLNPTSLQKLFREVR 72 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 + L+HPN+VKL ++ LV E+ G + ++L G + Sbjct: 73 IMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAK----FRQ 128 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 + + H +++RD+KA N+LLD D N K++DFG + + +G+ G+ Sbjct: 129 IVSAVQYCHQKY--IVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGN---KLDEFCGSP 183 Query: 244 GYAAPEYMSSGHLN-ARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 YAAPE + DV+S GV+L ++SG D + V + + Sbjct: 184 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 243 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCL 332 + P + + + Sbjct: 244 STDCENLLKKLLVLNPIKRGSLEQIMKDRW 273 >5IG1-A nrPDB Length = 344 Score = 222 bits (565), Expect = 3e-58, Method: Composition-based stats. Identities = 67/321 (20%), Positives = 118/321 (36%), Gaps = 41/321 (12%) Query: 55 FTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG 114 F ++ L + SVIG+G F V + TG V AVK + + + Sbjct: 11 FDLYDVDLKDKR----SVIGKGAFSTVHRC---------VNKRTGEVCAVKVIALKSLRS 57 Query: 115 HR--EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPL 172 + EI L H ++V + ++ H LV+E++ G L + + R Y + Sbjct: 58 SEINKIKREIGICSSLQHEHIVSMRRAFRDESHFYLVFEYVSGGELFDEIVTRKFYNEK- 116 Query: 173 PWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILL---DADYNAKLSDFGLARDGPM 229 L HS +I+RD+K N+LL D + K++DFGLA Sbjct: 117 ---DASACMHQILSALQHCHSK--NIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQ 171 Query: 230 GDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEEN 289 G + GT GY +PE + + DV++ GV+L +L G Sbjct: 172 GPTYF---GFAGTPGYLSPEVIRRVPYDTAVDVWACGVILYILLVGYPPF---------- 218 Query: 290 LVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRAL 349 W + ++ + ++ + L PK RPT+ ++++ Sbjct: 219 ---WEEDHQKLYAQIKNCQYDFPSPEWDSV-TTAAKELIKAMLEPNPKRRPTVQELLQHP 274 Query: 350 QQLQDNLGKPSQTNPVKDTKK 370 + ++ + K Sbjct: 275 WIARRDVPGSVHRQATLEELK 295 >4JDH-A nrPDB Length = 346 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 71/355 (20%), Positives = 133/355 (37%), Gaps = 47/355 (13%) Query: 27 LSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLA----------TRNFRPDSVIGEG 76 ++ +K G + + + + A IGEG Sbjct: 26 FQGARARQENGMPEKPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEG 85 Query: 77 GFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKL 136 G V + +G ++AVKK++ Q E+ + H N+V++ Sbjct: 86 STGIVCIATV---------RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEM 136 Query: 137 IGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPV 196 L + +V EF++ G+L + + + + V L + L+ LH+ Sbjct: 137 YNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA-----AVCLAVLQALSVLHAQ-- 189 Query: 197 KVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHL 256 VI+RDIK+ +ILL D KLSDFG + ++GT + APE +S Sbjct: 190 GVIHRDIKSDSILLTHDGRVKLSDFGFC--AQVSKEVPRRKSLVGTPYWMAPELISRLPY 247 Query: 257 NARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV-DWARPYLTSKRKVLLIVDNRLDTQ 315 D++S G++++E++ G+ + P K ++ D P L + KV Sbjct: 248 GPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKV----------- 296 Query: 316 YLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVKDTKK 370 + + + L +P R T ++++ G P+ P+ + Sbjct: 297 -----SPSLKGFLDRLLVRDPAQRATAAELLKH--PFLAKAGPPASIVPLMRQNR 344 >5J5T-A nrPDB Length = 370 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 65/287 (22%), Positives = 113/287 (39%), Gaps = 33/287 (11%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 +F IG G +G V+K TG + A+K + E + EI Sbjct: 4 EDFELIQRIGSGTYGDVYKA---------RNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 54 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 + HPN+V G L + + EF GSL++ G PL V+ + Sbjct: 55 MKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTG----PLSELQIAYVSRET 110 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYG 244 +GL +LHS ++RDIK +NILL + + KL+DFG++ + +GT Sbjct: 111 LQGLYYLHSK--GKMHRDIKGANILLTDNGHVKLADFGVS--AQITATIAKRKAFIGTPY 166 Query: 245 YAAPEYM---SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK 301 + APE G N D+++ G+ +E+ + + P + L+ + Sbjct: 167 WMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKL 226 Query: 302 RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + + L+ PK RPT +++++ Sbjct: 227 KDKMKW-------------SNSFHHFVKMALTKNPKKRPTAEKLLQH 260 >3Q5I-A nrPDB Length = 504 Score = 221 bits (563), Expect = 4e-58, Method: Composition-based stats. Identities = 74/346 (21%), Positives = 130/346 (37%), Gaps = 52/346 (15%) Query: 36 VAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTK 95 + + + ++ P E K+ F+ +G G +G V Sbjct: 8 SSGRENLYFQGIAINPGMYVRKKEGKIGESYFKV-RKLGSGAYGEVLLCKEKNGHSEK-- 64 Query: 96 PGTGLVIAVKKLNQEGFQG-------------HREWLTEINYLGQLSHPNLVKLIGYCLE 142 A+K + + F H E EI+ L L HPN++KL + Sbjct: 65 -------AIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEISLLKSLDHPNIIKLFDVFED 117 Query: 143 DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRD 202 ++ LV EF + G L + R + + N+ G+ +LH +++RD Sbjct: 118 KKYFYLVTEFYEGGELFEQIINRHKFDE----CDAANIMKQILSGICYLHKH--NIVHRD 171 Query: 203 IKASNILLDADY---NAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNAR 259 IK NILL+ N K+ DFGL+ Y +GT Y APE + N + Sbjct: 172 IKPENILLENKNSLLNIKIVDFGLSSFFS---KDYKLRDRLGTAYYIAPEVL-KKKYNEK 227 Query: 260 SDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPE 319 DV+S GV++ +L G V+ + Y D + + + Sbjct: 228 CDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFN-----------DWKNISD 276 Query: 320 EAVRMASVAVQCLSFEPKSRPTMDQVV--RALQQLQDNLGKPSQTN 363 EA + + L+++ R T ++ + R +++ +N+ K Q Sbjct: 277 EAKELIKLM---LTYDYNKRCTAEEALNSRWIKKYANNINKSDQKT 319 >3NCG-A nrPDB Length = 486 Score = 221 bits (562), Expect = 5e-58, Method: Composition-based stats. Identities = 68/332 (20%), Positives = 120/332 (36%), Gaps = 40/332 (12%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE--WLTE 121 + ++G+G FG V K T AVK +N+ + L E Sbjct: 21 AERYNIVCMLGKGSFGEVLKC---------KDRITQQEYAVKVINKASAKNKDTSTILRE 71 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 + L +L HPN++KL + +V E G L + + +R + + + Sbjct: 72 VELLKKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSE----HDAARII 127 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLARDGPMGDLSYVSTR 238 G+ ++H +++RD+K NILL++ D + K+ DFGL+ Sbjct: 128 KQVFSGITYMHKH--NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQN---TKMKD 182 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 +GT Y APE + G + + DV+S GV+L +LSG V+ + Sbjct: 183 RIGTAYYIAPEVL-RGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAF 241 Query: 299 TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGK 358 + + D + + + L+F P R T Q + Sbjct: 242 DLPQWRTISDDAK--------------DLIRKMLTFHPSLRITATQCLEH--PWIQKYSS 285 Query: 359 PSQTNPVKDTKKLGFKTGTTKSSEKRFTQKPF 390 + T + + +EK+ Q Sbjct: 286 ETPTISDLPSLESAMTNIRQFQAEKKLAQAAL 317 >2Q0N-A nrPDB Length = 301 Score = 221 bits (562), Expect = 6e-58, Method: Composition-based stats. Identities = 68/300 (22%), Positives = 123/300 (41%), Gaps = 37/300 (12%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 IGEG G V + +G ++AVKK++ Q E+ + H Sbjct: 36 KIGEGSTGIVCIATV---------RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 86 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 N+V++ L + +V EF++ G+L + + + + V L + L+ L Sbjct: 87 NVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA-----AVCLAVLQALSVL 141 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM 251 H+ VI+RDIK+ +ILL D KLSDFG + ++GT + APE + Sbjct: 142 HAQ--GVIHRDIKSDSILLTHDGRVKLSDFGFC--AQVSKEVPRRKSLVGTPYWMAPELI 197 Query: 252 SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV-DWARPYLTSKRKVLLIVDN 310 S D++S G++++E++ G+ + P K ++ D P L + KV Sbjct: 198 SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKV------ 251 Query: 311 RLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVKDTKK 370 + + + L +P R T ++++ G P+ P+ + Sbjct: 252 ----------SPSLKGFLDRLLVRDPAQRATAAELLKH--PFLAKAGPPASIVPLMRQNR 299 >6FD3-A nrPDB Length = 300 Score = 220 bits (561), Expect = 6e-58, Method: Composition-based stats. Identities = 60/286 (20%), Positives = 117/286 (40%), Gaps = 33/286 (11%) Query: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEI 122 + + IG+G G V+ T TG +A+K++N + + EI Sbjct: 20 PKKKYTRFEKIGQGASGTVY---------TALDIATGQEVAIKQMNLQQQPKKELIINEI 70 Query: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 + + +PN+V + L + +V E++ GSL + + + V Sbjct: 71 LVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-----MDEGQIAAVCR 125 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 + + L FLHS+ VI+RDIK+ NILL D + KL+DFG + ++GT Sbjct: 126 ECLQALDFLHSNQ--VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPE--QSKRSTMVGT 181 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 + APE ++ + D++S G++ +E++ G+ + P + L+ Sbjct: 182 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIAT--------- 232 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + Q + +CL + R + ++++ Sbjct: 233 ------NGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQH 272 >4XBR-A nrPDB Length = 366 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 68/300 (22%), Positives = 123/300 (41%), Gaps = 37/300 (12%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 IGEG G V + +G ++AVKK++ Q E+ + H Sbjct: 101 KIGEGSTGIVCIATV---------RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 151 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 N+V++ L + +V EF++ G+L + + + + V L + L+ L Sbjct: 152 NVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA-----AVCLAVLQALSVL 206 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM 251 H+ VI+RDIK+ +ILL D KLSDFG + ++GT + APE + Sbjct: 207 HAQ--GVIHRDIKSDSILLTHDGRVKLSDFGFC--AQVSKEVPRRKSLVGTPYWMAPELI 262 Query: 252 SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV-DWARPYLTSKRKVLLIVDN 310 S D++S G++++E++ G+ + P K ++ D P L + KV Sbjct: 263 SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKV------ 316 Query: 311 RLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVKDTKK 370 + + + L +P R T ++++ G P+ P+ + Sbjct: 317 ----------SPSLKGFLDRLLVRDPAQRATAAELLKH--PFLAKAGPPASIVPLMRQNR 364 >4FIE-A nrPDB Length = 423 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 71/358 (19%), Positives = 133/358 (37%), Gaps = 47/358 (13%) Query: 24 GLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLA----------TRNFRPDSVI 73 ++ +K G + + + + A I Sbjct: 100 DSPPPPARARQENGMPEKPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKI 159 Query: 74 GEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNL 133 GEG G V + +G ++AVKK++ Q E+ + H N+ Sbjct: 160 GEGSTGIVCIATV---------RSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENV 210 Query: 134 VKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHS 193 V++ L + +V EF++ G+L + + + + V L + L+ LH+ Sbjct: 211 VEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA-----AVCLAVLQALSVLHA 265 Query: 194 DPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSS 253 VI+RDIK+ +ILL D KLSDFG + ++GT + APE +S Sbjct: 266 Q--GVIHRDIKSDSILLTHDGRVKLSDFGFC--AQVSKEVPRRKSLVGTPYWMAPELISR 321 Query: 254 GHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV-DWARPYLTSKRKVLLIVDNRL 312 D++S G++++E++ G+ + P K ++ D P L + KV Sbjct: 322 LPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKV-------- 373 Query: 313 DTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVKDTKK 370 + + + L +P R T ++++ G P+ P+ + Sbjct: 374 --------SPSLKGFLDRLLVRDPAQRATAAELLKH--PFLAKAGPPASIVPLMRQNR 421 >3HZT-A nrPDB Length = 467 Score = 220 bits (561), Expect = 7e-58, Method: Composition-based stats. Identities = 62/291 (21%), Positives = 114/291 (39%), Gaps = 39/291 (13%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE---WLT 120 + ++ +G G +G V TG A+K + + L Sbjct: 3 SDRYQRVKKLGSGAYGEVLLC---------KDKLTGAERAIKIIKKSSVTTTSNSGALLD 53 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 E+ L QL HPN++KL + + + LV E + G L + + R + + + Sbjct: 54 EVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSE----VDAAVI 109 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLARDGPMGDLSYVST 237 G +LH +++RD+K N+LL++ D K+ DFGL+ +G Sbjct: 110 MKQVLSGTTYLHKH--NIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGG---KMK 164 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY 297 +GT Y APE + + + DV+S GV+L +L G + V+ + Sbjct: 165 ERLGTAYYIAPEVL-RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFS 223 Query: 298 LTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 D + +EA ++ + L++EP R + ++ + Sbjct: 224 FDP-----------PDWTQVSDEAKQLVKLM---LTYEPSKRISAEEALNH 260 >2OZO-A nrPDB Length = 613 Score = 220 bits (561), Expect = 8e-58, Method: Composition-based stats. Identities = 74/346 (21%), Positives = 137/346 (39%), Gaps = 39/346 (11%) Query: 31 KSSSTVAAAQKTEGEILSSTPV---KSFTFNELKLATRNFRPDSV-IGEGGFGCVFKGWL 86 + +S + +P + +L L N + +G G FG V +G Sbjct: 298 RITSPDKPRPMPMDTSVFESPFSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVY 357 Query: 87 DESTLTPTKPGTGLVIAVKKLNQEGFQGH-REWLTEINYLGQLSHPNLVKLIGYCLEDEH 145 +A+K L Q + E + E + QL +P +V+LIG C + E Sbjct: 358 RMRKKQID-------VAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEA 409 Query: 146 RLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKA 205 +LV E G L L + + +P + + G+ +L ++R++ A Sbjct: 410 LMLVMEMAGGGPLHKFLVGKR---EEIPVSNVAELLHQVSMGMKYLEEK--NFVHRNLAA 464 Query: 206 SNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG--TYGYAAPEYMSSGHLNARSDVY 263 N+LL + AK+SDFGL++ D SY + R G + APE ++ ++RSDV+ Sbjct: 465 RNVLLVNRHYAKISDFGLSKALGADD-SYYTARSAGKWPLKWYAPECINFRKFSSRSDVW 523 Query: 264 SFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAV 322 S+GV + E LS G++ +V+ ++ + PE Sbjct: 524 SYGVTMWEALSYGQKPYKK-----------------MKGPEVMAFIEQGKRMECPPECPP 566 Query: 323 RMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVKDT 368 + ++ C ++ + RP V + ++ +L + + Sbjct: 567 ELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGGSALEV 612 >3Q53-A nrPDB Length = 306 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 62/287 (21%), Positives = 120/287 (41%), Gaps = 35/287 (12%) Query: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEI 122 + + IG+G G V+ T TG +A++++N + + EI Sbjct: 19 PKKKYTRFEKIGQGASGTVY---------TAMDVATGQEVAIRQMNLQQQPKKELIINEI 69 Query: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 + + +PN+V + L + +V E++ GSL + + + V Sbjct: 70 LVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC-----MDEGQIAAVCR 124 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 + + L FLHS+ VI+RDIK+ NILL D + KL+DFG + ++GT Sbjct: 125 ECLQALEFLHSNQ--VIHRDIKSDNILLGMDGSVKLTDFGFCAQITPE--QSKRSTMVGT 180 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVD-WARPYLTSK 301 + APE ++ + D++S G++ +E++ G+ + P + L+ P L + Sbjct: 181 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNP 240 Query: 302 RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 K+ I +CL + + R + ++++ Sbjct: 241 EKLSAI----------------FRDFLNRCLEMDVEKRGSAKELIQH 271 >2BDW-A nrPDB Length = 362 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 115/301 (38%), Gaps = 37/301 (12%) Query: 53 KSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF 112 F N + N+ +G+G F V + TGL A K +N + Sbjct: 17 SEFMMNASTKFSDNYDVKEELGKGAFSVVRRC---------VHKTTGLEFAAKIINTKKL 67 Query: 113 --QGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFK 170 + ++ E +L HPN+V+L E+ LV++ + G L + R Y + Sbjct: 68 SARDFQKLEREARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSE 127 Query: 171 PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN---AKLSDFGLARDG 227 + + +A+ HS+ +++R++K N+LL + KL+DFGLA + Sbjct: 128 A----DASHCIQQILESIAYCHSN--GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEV 181 Query: 228 PMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE 287 + S GT GY +PE + + D+++ GV+L +L G Sbjct: 182 ---NDSEAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDE----- 233 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 D R Y K DT S+ L+ PK R T DQ ++ Sbjct: 234 ----DQHRLYAQIKAGAYDYPSPEWDT-----VTPEAKSLIDSMLTVNPKKRITADQALK 284 Query: 348 A 348 Sbjct: 285 V 285 >2Z7Q-A nrPDB Length = 321 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 68/233 (29%), Positives = 112/233 (48%), Gaps = 16/233 (6%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT--EI 122 +F V+G+G FG VF T+P +G + A+K L + + T E Sbjct: 28 SHFELLKVLGQGSFGKVFLVR------KVTRPDSGHLYAMKVLKKATLKVRDRVRTKMER 81 Query: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 + L ++HP +VKL + L+ +F++ G L L + + + F +AL Sbjct: 82 DILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 141 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 GL LHS + +IYRD+K NILLD + + KL+DFGL+++ D + GT Sbjct: 142 ----GLDHLHS--LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI--DHEKKAYSFCGT 193 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 Y APE ++ + +D +S+GVL+ E+L+G + L+ A+ Sbjct: 194 VEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAK 246 >3DXN-A nrPDB Length = 287 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 65/306 (21%), Positives = 119/306 (38%), Gaps = 42/306 (13%) Query: 49 STPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN 108 S+ ++ F L ++ +G G +G V TG A+K + Sbjct: 8 SSGRENLYFQGLS---DRYQRVKKLGSGAYGEVLLC---------KDKLTGAERAIKIIK 55 Query: 109 QEGFQGHRE---WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR 165 + L E+ L QL HPN++KL + + + LV E + G L + + R Sbjct: 56 KSSVTTTSNSGALLDEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILR 115 Query: 166 GAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFG 222 + + + G +LH +++RD+K N+LL++ D K+ DFG Sbjct: 116 QKFSE----VDAAVIMKQVLSGTTYLHKH--NIVHRDLKPENLLLESKSRDALIKIVDFG 169 Query: 223 LARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHN 282 L+ +G +GT Y APE + + + DV+S GV+L +L G Sbjct: 170 LSAHFEVGG---KMKERLGTAYYIAPEVL-RKKYDEKCDVWSCGVILYILLCGYPPFGGQ 225 Query: 283 RPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTM 342 + V+ + D + +EA ++ + L++EP R + Sbjct: 226 TDQEILKRVEKGKFSFDP-----------PDWTQVSDEAKQLVKLM---LTYEPSKRISA 271 Query: 343 DQVVRA 348 ++ + Sbjct: 272 EEALNH 277 >3ZZW-A nrPDB Length = 289 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 69/311 (22%), Positives = 123/311 (39%), Gaps = 39/311 (12%) Query: 56 TFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF-QG 114 E+ L+ F +GE FG V+KG L P +A+K L + Sbjct: 2 KLKEISLSAVRF--MEELGEDRFGKVYKGHL----FGPAPGEQTQAVAIKTLKDKAEGPL 55 Query: 115 HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFK---- 170 E+ E +L HPN+V L+G +D+ +++ + G L L R + Sbjct: 56 REEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGST 115 Query: 171 --------PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFG 222 L V++ A G+ +L S V+++D+ N+L+ N K+SD G Sbjct: 116 DDDRTVKSALEPPDFVHLVAQIAAGMEYLSSH--HVVHKDLATRNVLVYDKLNVKISDLG 173 Query: 223 LARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDH 281 L R+ D + + + APE + G + SD++S+GV+L E+ S G + Sbjct: 174 LFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCG 233 Query: 282 NRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPT 341 S + V+ ++ NR + + ++ ++C + P RP Sbjct: 234 Y-----------------SNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPR 276 Query: 342 MDQVVRALQQL 352 + L+ Sbjct: 277 FKDIHSRLRAW 287 >5XZW-A nrPDB Length = 471 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 74/354 (20%), Positives = 138/354 (38%), Gaps = 54/354 (15%) Query: 11 ADIFHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPD 70 D F + S+ K++S +A+ T S K+ F + + D Sbjct: 148 NDKFKQCLEQNKVDRIRSNLKNTSKIASPGLTSSTASSMVANKTGIFKDFSI------ID 201 Query: 71 SVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYLGQLS 129 V+G+G F V K + TG AVK +++ G+ + E+ L +L+ Sbjct: 202 EVVGQGAFATVKKA---------IERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLN 252 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 HP +V+L G+ + E +V EF+ G L + + GA + ++ + Sbjct: 253 HPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGR----EISRQILTAIK 308 Query: 190 FLHSDPVKVIYRDIKASNILLDADY--NAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAA 247 ++HS + + +RD+K NIL++ D K++DFGLA+ G+ S++ T GT Y A Sbjct: 309 YIHS--MGISHRDLKPDNILIEQDDPVLVKITDFGLAK--VQGNGSFMKT-FCGTLAYVA 363 Query: 248 PEYMSSGH-------------LNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWA 294 PE + ++ D++S G L+ IL+G + + + Sbjct: 364 PEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRG 423 Query: 295 RPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + + + L +P +R T + + Sbjct: 424 SYHEGPLKDFRI--------------SEEARDFIDSLLQVDPNNRSTAAKALNH 463 >4YFF-A nrPDB Length = 311 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 71/299 (23%), Positives = 134/299 (44%), Gaps = 36/299 (12%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 + L +IG G FG V+KG ++A+K+ + + Sbjct: 35 SHFHLQLSEIEFHEIIGSGSFGKVYKGRCRN-----------KIVAIKRYRANTYCSKSD 83 Query: 118 ---WLTEINYLGQLSHPNLVKLIGYCLEDEHRL-LVYEFMQKGSLENHLFRRGAYFKPLP 173 + E++ L QL+HP +++ +G CL D + +V +++ GSL + L + L Sbjct: 84 VDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRI---LD 140 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 ++ +A+D AKG+ +LH+ +I+RD+ + NILL D +A ++DFG +R D Sbjct: 141 LQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDED 200 Query: 234 YVSTRVMGTYGYAAPEYM-SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVD 292 + T+ G + APE ++DV+S+ + L EIL+G+ H +PA Sbjct: 201 NM-TKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAA---- 255 Query: 293 WARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 + + + ++S+ ++ + P+ RP +VV L++ Sbjct: 256 ------------ADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEE 302 >1U59-A nrPDB Length = 287 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 73/310 (23%), Positives = 129/310 (41%), Gaps = 36/310 (11%) Query: 58 NELKLATRNFRPDSV-IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH- 115 +L L N + +G G FG V +G +A+K L Q + Sbjct: 2 KKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQID-------VAIKVLKQGTEKADT 54 Query: 116 REWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 E + E + QL +P +V+LIG C + E +LV E G L L + + +P Sbjct: 55 EEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKR---EEIPVS 110 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 + + G+ +L ++RD+ A N+LL + AK+SDFGL++ D SY Sbjct: 111 NVAELLHQVSMGMKYLEEK--NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADD-SYY 167 Query: 236 STRVMG--TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVD 292 + R G + APE ++ ++RSDV+S+GV + E LS G++ Sbjct: 168 TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKK----------- 216 Query: 293 WARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 +V+ ++ + PE + ++ C ++ + RP V + ++ Sbjct: 217 ------MKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRAC 270 Query: 353 QDNLGKPSQT 362 +L + Sbjct: 271 YYSLASKVEG 280 >3KK8-A nrPDB Length = 284 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 67/290 (23%), Positives = 113/290 (38%), Gaps = 37/290 (12%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF--QGHREWLTE 121 + N+ +G+G F V + TGL A K +N + + ++ E Sbjct: 5 SDNYDVKEELGKGAFSVVRRC---------VHKTTGLEFAAKIINTKKLSARDFQKLERE 55 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 +L HPN+V+L E+ LV++ + G L + R Y + + Sbjct: 56 ARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEA----DASHCI 111 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN---AKLSDFGLARDGPMGDLSYVSTR 238 + +A+ HS+ +++R++K N+LL + KL+DFGLA + + S Sbjct: 112 QQILESIAYCHSN--GIVHRNLKPENLLLASKAKGAAVKLADFGLAIEV---NDSEAWHG 166 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 GT GY +PE + + D+++ GV+L +L G D R Y Sbjct: 167 FAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDE---------DQHRLYA 217 Query: 299 TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 K DT S+ L+ PK R T DQ ++ Sbjct: 218 QIKAGAYDYPSPEWDT-----VTPEAKSLIDSMLTVNPKKRITADQALKV 262 >2VN9-A nrPDB Length = 301 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 63/298 (21%), Positives = 109/298 (36%), Gaps = 36/298 (12%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF--QGHREWLTE 121 T ++ +G+G F V + K TG A K +N + + H++ E Sbjct: 3 TDEYQLFEELGKGAFSVVRRC---------MKIPTGQEYAAKIINTKKLSARDHQKLERE 53 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 L HPN+V+L E+ LV++ + G L + R Y + + Sbjct: 54 ARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEA----DASHCI 109 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN---AKLSDFGLARDGPMGDLSYVSTR 238 + + H + +++RD+K N+LL + KL+DFGLA + ++ Sbjct: 110 QQILESVNHCHLN--GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWF--G 165 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 GT GY +PE + D+++ GV+L +L G D R Y Sbjct: 166 FAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDE---------DQHRLYQ 216 Query: 299 TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNL 356 K DT + + L+ P R T + ++ Q + Sbjct: 217 QIKAGAYDFPSPEWDT-----VTPEAKDLINKMLTINPAKRITASEALKHPWICQRST 269 >5FG8-A nrPDB Length = 285 Score = 218 bits (556), Expect = 2e-57, Method: Composition-based stats. Identities = 62/290 (21%), Positives = 109/290 (37%), Gaps = 36/290 (12%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF--QGHREWLTE 121 + N+ +G+G F V + + TG A K +N + + ++ E Sbjct: 13 SDNYDIKEELGKGAFSIVKRC---------VQKSTGFEFAAKIINTKKLTARDFQKLERE 63 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 +L HPN+V+L E+ + LV++ + G L + R Y + + Sbjct: 64 ARICRKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEA----DASHCI 119 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN---AKLSDFGLARDGPMGDLSYVSTR 238 + + H + V++RD+K N+LL + KL+DFGLA + ++ Sbjct: 120 QQILESVNHCHQN--GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWF--G 175 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 GT GY +PE + D+++ GV+L +L G D R Y Sbjct: 176 FAGTPGYLSPEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDE---------DQHRLYS 226 Query: 299 TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 K DT ++ Q L+ P R T + ++ Sbjct: 227 QIKAGAYDYPSPEWDT-----VTPEAKNLINQMLTVNPNKRITAAEALKH 271 >4KS7-A nrPDB Length = 292 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 68/288 (23%), Positives = 119/288 (41%), Gaps = 35/288 (12%) Query: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP 131 IGEG G V + +G +AVK ++ Q E+ + H Sbjct: 30 KIGEGSTGIVCLA---------REKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHF 80 Query: 132 NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFL 191 N+V++ L E ++ EF+Q G+L + + + + + V + LA+L Sbjct: 81 NVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIA-----TVCEAVLQALAYL 135 Query: 192 HSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM 251 H+ VI+RDIK+ +ILL D KLSDFG + ++GT + APE + Sbjct: 136 HAQ--GVIHRDIKSDSILLTLDGRVKLSDFGFC--AQISKDVPKRKSLVGTPYWMAPEVI 191 Query: 252 SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEEN-LVDWARPYLTSKRKVLLIVDN 310 S D++S G++++E++ G+ + P + L D P L + KV Sbjct: 192 SRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKV------ 245 Query: 311 RLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGK 358 + + + L +P+ R T +++ LQ L + Sbjct: 246 ----------SPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPE 283 >4CQG-A nrPDB Length = 331 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 66/290 (22%), Positives = 118/290 (40%), Gaps = 36/290 (12%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF-QGHREWLTEINYL 125 + IG GGF V TG ++A+K +++ TEI+ L Sbjct: 11 YELYETIGTGGFAKVKLAC---------HVLTGEMVAIKIMDKNALGSDLPRVKTEIDAL 61 Query: 126 GQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 L H ++ +L +V E+ G L +++ + + V Sbjct: 62 KSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRV----VFRQIL 117 Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGY 245 +A++HS +RD+K N+L D ++ KL DFGL P G+ Y G+ Y Sbjct: 118 SAVAYVHSQ--GYAHRDLKPENLLFDENHKLKLIDFGLCAK-PKGNKDYHLQECCGSLAY 174 Query: 246 AAPEYMSSGHL-NARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKV 304 AAPE + + +DV+S G+LL ++ G D ++N++ + + K +V Sbjct: 175 AAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFD------DDNVMALYKKIMRGKYEV 228 Query: 305 LLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQD 354 ++L ++ + Q L +PK R +M ++ +QD Sbjct: 229 ---------PKWLSPSSILLLQ---QMLQVDPKKRISMRNLLNHPWVMQD 266 >3DFA-A nrPDB Length = 286 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 64/290 (22%), Positives = 111/290 (38%), Gaps = 38/290 (13%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE--WLTE 121 + ++G+G FG V K T AVK +N+ + L E Sbjct: 21 AERYNIVCMLGKGSFGEVLKC---------KDRITQQEYAVKVINKASAKNKDTSTILRE 71 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 + L +L HPN++KL + +V E G L + + +R + + + Sbjct: 72 VELLKKLDHPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSE----HDAARII 127 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLARDGPMGDLSYVSTR 238 G+ ++H +++RD+K NILL++ D + K+ DFGL+ Sbjct: 128 KQVFSGITYMHKH--NIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQN---TKMKD 182 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 +GT Y APE + G + + DV+S GV+L +LSG V+ + Sbjct: 183 RIGTAYYIAPEVL-RGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAF 241 Query: 299 TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + D + + + L+F P R T Q + Sbjct: 242 DLPQWRTISDDAK--------------DLIRKMLTFHPSLRITATQCLEH 277 >4KRC-A nrPDB Length = 317 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 70/306 (22%), Positives = 126/306 (41%), Gaps = 34/306 (11%) Query: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-REWLTE 121 ++ F+ +G G + V+KG TG+ +A+K++ + +G + E Sbjct: 3 SSSQFKQLEKLGNGTYATVYKG---------LNKTTGVYVALKEVKLDSEEGTPSTAIRE 53 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR--GAYFKPLPWFLRVN 179 I+ + +L H N+V+L + LV+EFM L+ ++ R G + L L Sbjct: 54 ISLMKELKHENIVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKY 112 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 +GLAF H + K+++RD+K N+L++ KL DFGLAR + ++ S V Sbjct: 113 FQWQLLQGLAFCHEN--KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV 170 Query: 240 MGTYGYAAPEYMSSGH-LNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV--DWARP 296 T Y AP+ + + D++S G +L E+++GK ++ L+ P Sbjct: 171 --TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTP 228 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEEAVR--------------MASVAVQCLSFEPKSRPTM 342 + V + + Q P +R + L P R + Sbjct: 229 NESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSA 288 Query: 343 DQVVRA 348 Q + Sbjct: 289 KQALHH 294 >3H4J-B nrPDB Length = 336 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 67/307 (21%), Positives = 122/307 (39%), Gaps = 44/307 (14%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR---EWLTEIN 123 + +GEG FG V T T +A+K ++++ + EI+ Sbjct: 11 YIIRETLGEGSFGKVKLA---------THYKTQQKVALKFISRQLLKKSDMHMRVEREIS 61 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 YL L HP+++KL ++V E+ G L +++ + + Sbjct: 62 YLKLLRHPHIIKLYDVITTPTDIVMVIEYA-GGELFDYIVEKKR----MTEDEGRRFFQQ 116 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 + + H K+++RD+K N+LLD + N K++DFGL+ G+ S G+ Sbjct: 117 IICAIEYCHRH--KIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTS---CGSP 171 Query: 244 GYAAPEYMSSGHL-NARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 YAAPE ++ DV+S G++L +L G+ D D P L K Sbjct: 172 NYAAPEVINGKLYAGPEVDVWSCGIVLYVMLVGRLPFD-----------DEFIPNLFKKV 220 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQT 362 + V + S+ + + +P R T+ ++ R N+ P Sbjct: 221 NSCVYV-------MPDFLSPGAQSLIRRMIVADPMQRITIQEIRRDPWF---NVNLPDYL 270 Query: 363 NPVKDTK 369 P+++ + Sbjct: 271 RPMEEVQ 277 >4TPT-A nrPDB Length = 303 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 81/331 (24%), Positives = 141/331 (42%), Gaps = 49/331 (14%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 + V+G+G FG + T TG V+ +K+L + + + +LTE+ + Sbjct: 1 DLIHGEVLGKGFFGQ---------AIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVM 51 Query: 126 GQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 L HPN++K IG +D+ L+ E+++ G+L++ L P PW +V A A Sbjct: 52 RSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMD----PFPWQQKVRFAKGIA 107 Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMG--------------- 230 G+A+LHS + +I+RD+ + N L+ D ++DFGL+R Sbjct: 108 SGMAYLHS--MCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRT 165 Query: 231 ---DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE 287 + V+G + APE ++ + D++SFG++L EI+ G+ D Sbjct: 166 LRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII-GQVYADP------ 218 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 D L V L + + T P +A C EP+SRP ++ Sbjct: 219 ----DCLPRTLDFGLNVKLFWEKFVPTDCPPA----FFPLAAICCRLEPESRPAFSKLED 270 Query: 348 ALQQLQDNLGKPSQTNPVKDTKKLGFKTGTT 378 + + L LG+ P + ++L Sbjct: 271 SFEALSLYLGELGIPLP-AELEELDHTVSMQ 300 >2V7O-A nrPDB Length = 336 Score = 218 bits (555), Expect = 4e-57, Method: Composition-based stats. Identities = 61/301 (20%), Positives = 110/301 (36%), Gaps = 42/301 (13%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF--QGHREWLTE 121 T +++ +G+G F V + K A K +N + + H++ E Sbjct: 30 TDDYQLFEELGKGAFSVVRRC---------VKKTPTQEYAAKIINTKKLSARDHQKLERE 80 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 L HPN+V+L E+ LV++ + G L + R Y + + Sbjct: 81 ARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEA----DASHCI 136 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN---AKLSDFGLARDGPMGDLSYVSTR 238 + + +H +++RD+K N+LL + KL+DFGLA + ++ Sbjct: 137 HQILESVNHIHQHD--IVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWF--G 192 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 GT GY +PE + D+++ GV+L +L G Sbjct: 193 FAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDED--------------- 237 Query: 299 TSKRKVLLIVDNRLDTQYLPEE---AVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 + K+ + PE ++ Q L+ P R T DQ ++ Q + Sbjct: 238 --QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRS 295 Query: 356 L 356 Sbjct: 296 T 296 >4RLP-A nrPDB Length = 288 Score = 218 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 69/254 (27%), Positives = 108/254 (42%), Gaps = 22/254 (8%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF----QGHR 116 K+ F V+G+GG+G VF+ T TG + A+K L + + Sbjct: 1 KIRPECFELLRVLGKGGYGKVFQVR------KVTGANTGKIFAMKVLKKAMIVRNAKDTA 54 Query: 117 EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 E N L ++ HP +V LI L+ E++ G L L R G + + F Sbjct: 55 HTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFY 114 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 +++ L LH +IYRD+K NI+L+ + KL+DFGL ++ V+ Sbjct: 115 LAEISM----ALGHLHQK--GIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGT--VT 166 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV----D 292 GT Y APE + N D +S G L+ ++L+G K + + Sbjct: 167 HTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKL 226 Query: 293 WARPYLTSKRKVLL 306 PYLT + + LL Sbjct: 227 NLPPYLTQEARDLL 240 >4JXF-A nrPDB Length = 266 Score = 218 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 65/289 (22%), Positives = 117/289 (40%), Gaps = 37/289 (12%) Query: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH---REWL 119 +F+ +++G+G F V++ TGL +A+K ++++ + Sbjct: 5 KIEDFKVGNLLGKGSFAGVYRA---------ESIHTGLEVAIKMIDKKAMYKAGMVQRVQ 55 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 E+ QL HP++++L Y + + LV E G + +L R KP + Sbjct: 56 NEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNR---VKPFSENEARH 112 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 G+ +LHS +++RD+ SN+LL + N K++DFGLA M + + + Sbjct: 113 FMHQIITGMLYLHSH--GILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYT--L 168 Query: 240 MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLT 299 GT Y +PE + SDV+S G + +L G+ D + N V A Sbjct: 169 CGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLA----- 223 Query: 300 SKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 D + ++ + Q L P R ++ V+ Sbjct: 224 -------------DYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDH 259 >2JC6-A nrPDB Length = 334 Score = 218 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 64/299 (21%), Positives = 112/299 (37%), Gaps = 40/299 (13%) Query: 58 NELKLATRN----FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ 113 + K + F +G G F V + TG + AVK + ++ + Sbjct: 11 SSWKKQAEDIKKIFEFKETLGTGAFSEVVLA---------EEKATGKLFAVKCIPKKALK 61 Query: 114 GHREWL-TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPL 172 G + EI L ++ H N+V L H LV + + G L + + +G Y + Sbjct: 62 GKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEK- 120 Query: 173 PWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILL---DADYNAKLSDFGLARDGPM 229 + + +LH + +++RD+K N+L D + +SDFGL++ Sbjct: 121 ---DASTLIRQVLDAVYYLH--RMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGK 175 Query: 230 GDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEEN 289 GD V + GT GY APE ++ + D +S GV+ +L G +K Sbjct: 176 GD---VMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFE 232 Query: 290 LVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + L + D+ Y + + + +P R T +Q R Sbjct: 233 QI--------------LKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARH 277 >4BBM-A nrPDB Length = 331 Score = 217 bits (553), Expect = 5e-57, Method: Composition-based stats. Identities = 71/302 (23%), Positives = 116/302 (38%), Gaps = 33/302 (10%) Query: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG--HREWLT 120 + + ++GEG +G V K TG ++A+KK + + + Sbjct: 23 SMEKYENLGLVGEGSYGMVMKC---------RNKDTGRIVAIKKFLESDDDKMVKKIAMR 73 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 EI L QL H NLV L+ C + + LV+EF+ L++ + L + + Sbjct: 74 EIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDL----ELFPNGLDYQVVQKY 129 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 G+ F HS +I+RDIK NIL+ KL DFG AR Y + Sbjct: 130 LFQIINGIGFCHSH--NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVY--DDEV 185 Query: 241 GTYGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLT 299 T Y APE + DV++ G L+ E+ G+ + + + L Sbjct: 186 ATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLI 245 Query: 300 SKRKVLLIVDNRLDTQYLPEEAVR-------------MASVAVQCLSFEPKSRPTMDQVV 346 + + L + LPE R + +A +CL +P RP +++ Sbjct: 246 PRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELL 305 Query: 347 RA 348 Sbjct: 306 HH 307 >4FG9-A nrPDB Length = 320 Score = 217 bits (552), Expect = 8e-57, Method: Composition-based stats. Identities = 72/338 (21%), Positives = 127/338 (37%), Gaps = 39/338 (11%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL- 119 + + V+G G F V + T ++A+K + +E +G + Sbjct: 14 EDIRDIYDFRDVLGTGAFSEV---------ILAEDKRTQKLVAIKCIAKEALEGKEGSME 64 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 EI L ++ HPN+V L H L+ + + G L + + +G Y + Sbjct: 65 NEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTER----DASR 120 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNIL---LDADYNAKLSDFGLARDGPMGDLSYVS 236 + + +LH + +++RD+K N+L LD D +SDFGL++ M D V Sbjct: 121 LIFQVLDAVKYLH--DLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSK---MEDPGSVL 175 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 + GT GY APE ++ + D +S GV+ +L G AK + Sbjct: 176 STACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQI----- 230 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNL 356 L + D+ Y + + + +P+ R T +Q ++ D Sbjct: 231 ---------LKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTA 281 Query: 357 GKPSQTNPVKDTKKLGFKTGTTKSSEKRFTQKPFGRHL 394 + V + K F K + F RH+ Sbjct: 282 LDKNIHQSVSEQIKKNFAKSKWKQA---FNATAVVRHM 316 >4L42-A nrPDB Length = 346 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 69/254 (27%), Positives = 108/254 (42%), Gaps = 22/254 (8%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF----QGHR 116 K+ F V+G+GG+G VF+ T TG + A+K L + + Sbjct: 14 KIRPECFELLRVLGKGGYGKVFQVR------KVTGANTGKIFAMKVLKKAMIVRNAKDTA 67 Query: 117 EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 E N L ++ HP +V LI L+ E++ G L L R G + + F Sbjct: 68 HTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFY 127 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 +++ L LH +IYRD+K NI+L+ + KL+DFGL ++ V+ Sbjct: 128 LAEISM----ALGHLHQK--GIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGT--VT 179 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV----D 292 GT Y APE + N D +S G L+ ++L+G K + + Sbjct: 180 HTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKL 239 Query: 293 WARPYLTSKRKVLL 306 PYLT + + LL Sbjct: 240 NLPPYLTQEARDLL 253 >5U6Y-A nrPDB Length = 461 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 62/287 (21%), Positives = 107/287 (37%), Gaps = 36/287 (12%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF--QGHREWLTEINY 124 ++ +G+G F V + K G A K +N + + H++ E Sbjct: 2 YQLFEELGKGAFSVVRRC---------VKVLAGQEYAAKIINTKKLSARDHQKLEREARI 52 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 L HPN+V+L E+ H L+++ + G L + R Y + + Sbjct: 53 CRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEA----DASHCIQQI 108 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADYN---AKLSDFGLARDGPMGDLSYVSTRVMG 241 + + LH + V++RD+K N+LL + KL+DFGLA + ++ G Sbjct: 109 LEAV--LHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWF--GFAG 164 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK 301 T GY +PE + D+++ GV+L +L G D R Y K Sbjct: 165 TPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDE---------DQHRLYQQIK 215 Query: 302 RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 DT + + L+ P R T + ++ Sbjct: 216 AGAYDFPSPEWDT-----VTPEAKDLINKMLTINPSKRITAAEALKH 257 >2VZ6-A nrPDB Length = 313 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 62/287 (21%), Positives = 107/287 (37%), Gaps = 36/287 (12%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF--QGHREWLTEINY 124 ++ +G+G F V + K G A K +N + + H++ E Sbjct: 24 YQLFEELGKGAFSVVRRC---------VKVLAGQEYAAKIINTKKLSARDHQKLEREARI 74 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 L HPN+V+L E+ H L+++ + G L + R Y + + Sbjct: 75 CRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEA----DASHCIQQI 130 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADYN---AKLSDFGLARDGPMGDLSYVSTRVMG 241 + + LH + V++RD+K N+LL + KL+DFGLA + ++ G Sbjct: 131 LEAV--LHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWF--GFAG 186 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK 301 T GY +PE + D+++ GV+L +L G D R Y K Sbjct: 187 TPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDE---------DQHRLYQQIK 237 Query: 302 RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 DT + + L+ P R T + ++ Sbjct: 238 AGAYDFPSPEWDT-----VTPEAKDLINKMLTINPSKRITAAEALKH 279 >2UV2-A nrPDB Length = 325 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 61/290 (21%), Positives = 118/290 (40%), Gaps = 37/290 (12%) Query: 65 RNF-RPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEIN 123 +F +G+G FG V+K E+++ A K ++ + + +++ EI+ Sbjct: 36 EDFWEIIGELGDGAFGKVYKAQNKETSVLA---------AAKVIDTKSEEELEDYMVEID 86 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 L HPN+VKL+ + + ++ EF G+++ + +PL V Sbjct: 87 ILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLE---LERPLTESQIQVVCKQ 143 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 L +LH + K+I+RD+KA NIL D + KL+DFG++ +GT Sbjct: 144 TLDALNYLHDN--KIIHRDLKAGNILFTLDGDIKLADFGVSAKNTR--TIQRRDSFIGTP 199 Query: 244 GYAAPEYM-----SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 + APE + + ++DV+S G+ L+E+ + P + + + P Sbjct: 200 YWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPT 259 Query: 299 TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 ++ + +CL +R T Q+++ Sbjct: 260 LAQ---------------PSRWSSNFKDFLKKCLEKNVDARWTTSQLLQH 294 >3IS5-A nrPDB Length = 285 Score = 216 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 66/286 (23%), Positives = 109/286 (38%), Gaps = 34/286 (11%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT-EINYL 125 F +G G FG V + +GL +K +N++ Q E + EI L Sbjct: 24 FIFKRKLGSGAFGDVH---------LVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVL 74 Query: 126 GQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 L HPN++K+ + + +V E + G L + A K L + Sbjct: 75 KSLDHPNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMM 134 Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 LA+ HS V+++D+K NIL K+ DFGLA + ST GT Sbjct: 135 NALAYFHSQ--HVVHKDLKPENILFQDTSPHSPIKIIDFGLA---ELFKSDEHSTNAAGT 189 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 Y APE + + D++S GV++ +L+G L + Sbjct: 190 ALYMAPEV-FKRDVTFKCDIWSAGVVMYFLLTGCLPFTGTS--------------LEEVQ 234 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + + P + + Q L+ +P+ RP+ QV+ Sbjct: 235 QKATYKEPNYAVECRP-LTPQAVDLLKQMLTKDPERRPSAAQVLHH 279 >4D2V-A nrPDB Length = 356 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 64/290 (22%), Positives = 110/290 (37%), Gaps = 36/290 (12%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF-QGHREWLTEINYL 125 + IG GGF V TG ++A+K +++ TEI L Sbjct: 31 YELHETIGTGGFAKVKLAC---------HILTGEMVAIKIMDKNTLGSDLPRIKTEIEAL 81 Query: 126 GQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 L H ++ +L +V E+ G L +++ + + V Sbjct: 82 KNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRV----VFRQIV 137 Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGY 245 +A++HS +RD+K N+L D + KL DFGL P G+ Y G Y Sbjct: 138 SAVAYVHSQ--GYAHRDLKPENLLFDEYHKLKLIDFGLCAK-PKGNKDYHLQACCGALAY 194 Query: 246 AAPEYMSSGHL-NARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKV 304 AAPE + + +DV+S G+LL ++ G D + A + + + Sbjct: 195 AAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDV------ 248 Query: 305 LLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQD 354 ++L ++ + Q L +PK R +M ++ +QD Sbjct: 249 ---------PKWLSPSSILLLQ---QMLQVDPKKRISMKNLLNHPWIMQD 286 >4AGU-A nrPDB Length = 311 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 75/322 (23%), Positives = 117/322 (36%), Gaps = 41/322 (12%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL--NQEGFQGHREWLTE 121 + IGEG +G VFK TG ++A+KK +++ + L E Sbjct: 2 MEKYEKIGKIGEGSYGVVFKC---------RNRDTGQIVAIKKFLESEDDPVIKKIALRE 52 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 I L QL HPNLV L+ LV+E+ L Y + +P L ++ Sbjct: 53 IRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDH----TVLHELDRYQRGVPEHLVKSIT 108 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 + + F H I+RD+K NIL+ KL DFG AR Y + Sbjct: 109 WQTLQAVNFCHKH--NCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYY--DDEVA 164 Query: 242 TYGYAAPEYM-SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 T Y +PE + DV++ G + E+LSG + L+ L Sbjct: 165 TRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIP 224 Query: 301 KR-------------KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVV- 346 + K+ D P + + CL +P R T +Q++ Sbjct: 225 RHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLH 284 Query: 347 -------RALQQLQDNLGKPSQ 361 R ++ L KP++ Sbjct: 285 HPYFENIREIEDLAKEHDKPAE 306 >6ED6-A nrPDB Length = 415 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 65/315 (20%), Positives = 117/315 (37%), Gaps = 37/315 (11%) Query: 6 SSRVKADIFHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATR 65 S + + +G +S + L + + + + L+ L++ Sbjct: 36 RSPINVESLLDGLNSLVLDLDFPALRKNKNID-------NFLNRYEKIVKKIRGLQMKAE 88 Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE---WLTEI 122 ++ VIG G FG V + V A+K L++ + + E Sbjct: 89 DYDVVKVIGRGAFGEV---------QLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEER 139 Query: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 + + + P +V+L +D + +V E+M G L N + +P Sbjct: 140 DIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNY-----DVPEKWAKFYTA 194 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 + L +HS + +I+RD+K N+LLD + KL+DFG + + T +GT Sbjct: 195 EVVLALDAIHS--MGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDT-AVGT 251 Query: 243 YGYAAPEYMSS----GHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 Y +PE + S G D +S GV L E+L G ++LV + Sbjct: 252 PDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPF------YADSLVGTYSKIM 305 Query: 299 TSKRKVLLIVDNRLD 313 K + D + Sbjct: 306 DHKNSLCFPEDAEIS 320 >4CZT-A nrPDB Length = 464 Score = 215 bits (548), Expect = 3e-56, Method: Composition-based stats. Identities = 58/285 (20%), Positives = 109/285 (38%), Gaps = 37/285 (12%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR---EWLTEIN 123 + +GEG F V E G +A+K +++E ++ + EI+ Sbjct: 13 YELGRTLGEGTFAKVKFARNVE---------NGDNVAIKVIDKEKVLKNKMIAQIKREIS 63 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 + + HPN++++ V EF+ G L + + G + Sbjct: 64 TMKLIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEAR----KYFQQ 119 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 + + HS V +RD+K N+LLDA+ K+SDFGL+ + GT Sbjct: 120 LINAVDYCHSR--GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP 177 Query: 244 GYAAPEYMSSGHLN-ARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 Y APE +++ + A++D++S GV+L +++G + + + A Sbjct: 178 NYVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEF------ 231 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 P + + + L P +R T +V+ Sbjct: 232 ------------TCPPWFSASAKKLIKRILDPNPATRITFAEVIE 264 >3BHH-A nrPDB Length = 295 Score = 215 bits (548), Expect = 3e-56, Method: Composition-based stats. Identities = 63/301 (20%), Positives = 110/301 (36%), Gaps = 42/301 (13%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF--QGHREWLTE 121 T ++ IG+G F V + K TG A K +N + + H++ E Sbjct: 3 TDEYQLYEDIGKGAFSVVRRC---------VKLCTGHEYAAKIINTKKLSARDHQKLERE 53 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 L H N+V+L E+ LV++ + G L + R Y + + Sbjct: 54 ARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEA----DASHCI 109 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN---AKLSDFGLARDGPMGDLSYVSTR 238 + + LH + V++RD+K N+LL + KL+DFGLA + ++ Sbjct: 110 QQILEAV--LHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWF--G 165 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 GT GY +PE + D+++ GV+L +L G Sbjct: 166 FAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDED--------------- 210 Query: 299 TSKRKVLLIVDNRLDTQYLPEE---AVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 + K+ + PE ++ Q L+ P R T + ++ Q + Sbjct: 211 --QHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRS 268 Query: 356 L 356 Sbjct: 269 T 269 >2W96-B nrPDB Length = 306 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 80/325 (24%), Positives = 132/325 (40%), Gaps = 48/325 (14%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN----QEGFQGHRE 117 +AT + P + IG G +G V+K P +G +A+K + +EG Sbjct: 1 MATSRYEPVAEIGVGAYGTVYKA---------RDPHSGHFVALKSVRVPNGEEGLPIS-- 49 Query: 118 WLTEINYLGQLS---HPNLVKLIGYCLEDE-----HRLLVYEFMQKGSLENHLFRRGAYF 169 + E+ L +L HPN+V+L+ C LV+E + L +L + A Sbjct: 50 TVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDK--APP 106 Query: 170 KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPM 229 LP ++ +GL FLH++ +++RD+K NIL+ + KL+DFGLAR + Sbjct: 107 PGLPAETIKDLMRQFLRGLDFLHANC--IVHRDLKPENILVTSGGTVKLADFGLAR---I 161 Query: 230 GDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEEN 289 V+ T Y APE + D++S G + E+ K N A + Sbjct: 162 YSYQMALDPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLG 221 Query: 290 LV----------DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSR 339 + DW R ++ R R +PE A + ++ L+F P R Sbjct: 222 KIFDLIGLPPEDDWPRD-VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKR 280 Query: 340 PTMDQVVRALQQLQDNLGKPSQTNP 364 + + LQ + + NP Sbjct: 281 ISA------FRALQHSYLHKDEGNP 299 >4UZD-A nrPDB Length = 287 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 67/306 (21%), Positives = 121/306 (39%), Gaps = 41/306 (13%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG---HRE 117 + A +F +G+G FG V+ + + ++A+K L + + + Sbjct: 4 QWALEDFEIGRPLGKGKFGNVYLA---------REKQSKFILALKVLFKAQLEKAGVEHQ 54 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 E+ L HPN+++L GY + L+ E+ G++ L + + + Sbjct: 55 LRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRT---- 110 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 + A L++ HS +VI+RDIK N+LL + K++DFG + P S T Sbjct: 111 ATYITELANALSYCHSK--RVIHRDIKPENLLLGSAGELKIADFGWSVHAP----SSRRT 164 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY 297 + GT Y PE + + + D++S GVL E L GK + N + + Sbjct: 165 TLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRI------ 218 Query: 298 LTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLG 357 +R++ + + + L P RP + +V+ + N Sbjct: 219 ------------SRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPW-ITANSS 265 Query: 358 KPSQTN 363 KPS Sbjct: 266 KPSNCQ 271 >4RGJ-A nrPDB Length = 520 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 61/336 (18%), Positives = 126/336 (37%), Gaps = 42/336 (12%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ---GHREW 118 + ++ ++G+G FG V + TG A+K ++++ + Sbjct: 57 VFNEQYKGIKILGKGSFGEV---------ILSRDKHTGHEYAIKVISKKHVKRKTDKESL 107 Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 L E+ L L H N++KL + ++ + LV + G L + + R +++ Sbjct: 108 LREVELLKMLDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYE----IDAA 163 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLD----ADYNAKLSDFGLARDGPMGDLSY 234 + G+ ++H + V++RD+K NILL+ D K+ DFGL+ + S Sbjct: 164 RIIKQILSGITYMHKN--NVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHF---EYSK 218 Query: 235 VSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWA 294 +GT Y AP+ + G + + D++S GV+L +LSG + + V+ Sbjct: 219 KMKDKIGTAYYIAPDVLH-GTYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAG 277 Query: 295 RPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQD 354 + D + + + + + L + R + + + Sbjct: 278 KYTF--------------DLPQFKKISDKAKDLIKKMLMYTSAVRISARDALEH--EWIK 321 Query: 355 NLGKPSQTNPVKDTKKLGFKTGTTKSSEKRFTQKPF 390 + N + +L S ++ Q Sbjct: 322 MMTSKDNLNIDIPSLELSIANIRQFQSTQKLAQAAL 357 >3TXO-A nrPDB Length = 353 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 70/283 (24%), Positives = 112/283 (39%), Gaps = 39/283 (13%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW-- 118 +L NF V+G+G FG V + E TG + AVK L ++ + Sbjct: 19 RLGIDNFEFIRVLGKGSFGKVMLARVKE---------TGDLYAVKVLKKDVILQDDDVEC 69 Query: 119 -LTEINYLGQLS-HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 +TE L HP L +L + V EF+ G L H+ + + + F Sbjct: 70 TMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARF- 128 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 A + L FLH +IYRD+K N+LLD + + KL+DFG+ ++G ++ + Sbjct: 129 ---YAAEIISALMFLHDK--GIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVT--T 181 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 GT Y APE + D ++ GVLL E+L G + + Sbjct: 182 ATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI----- 236 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSR 339 + D + +L E+A + ++ P R Sbjct: 237 ----------LNDEVVYPTWLHEDATG---ILKSFMTKNPTMR 266 >6FDY-U nrPDB Length = 276 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 69/284 (24%), Positives = 113/284 (39%), Gaps = 36/284 (12%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH--REWLTEI 122 F +G G + V+K + K T V+A+K + ++ LTEI Sbjct: 11 DGFILTERLGSGTYATVYKAY--------AKKDTREVVAIKCVAKKSLNKASVENLLTEI 62 Query: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 L + HP++V+L + + ++ L+ EF G L + R LP + Sbjct: 63 EILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRI----LPEKVARVFMQ 118 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLD--ADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 A L FLH + + D+K NILL + KL+DFG A+ D +V + Sbjct: 119 QLASALQFLHER--NISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHV---LR 173 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 G+ Y APE + +AR D++S GV+L E L G+ ++ E + S Sbjct: 174 GSPLYMAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKI-------RS 226 Query: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQ 344 R + L + L + + L +P R + Sbjct: 227 NRVIELPLRPLLSRDC--------RDLLQRLLERDPSRRISFQD 262 >5D7A-A nrPDB Length = 308 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 72/312 (23%), Positives = 120/312 (38%), Gaps = 44/312 (14%) Query: 49 STPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN 108 + + L+ F ++G G +G V+KG TG + A+K ++ Sbjct: 1 GSGADEIDLSALRDPAGIFELVELVGNGTYGQVYKG---------RHVKTGQLAAIKVMD 51 Query: 109 QEGFQGHREWLTEINYLGQLSHP-NLVKLIGYCLE------DEHRLLVYEFMQKGSLENH 161 G E EIN L + SH N+ G ++ D+ LV EF GS+ + Sbjct: 52 VTG-DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDL 110 Query: 162 LFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDF 221 + W + + +GL+ LH KVI+RDIK N+LL + KL DF Sbjct: 111 IKNTKGNTLKEEWI--AYICREILRGLSHLHQH--KVIHRDIKGQNVLLTENAEVKLVDF 166 Query: 222 GLARDGPMGDLSYVSTRVMGTYGYAAPEYMS-----SGHLNARSDVYSFGVLLLEILSGK 276 G++ + +GT + APE ++ + +SD++S G+ +E+ G Sbjct: 167 GVS--AQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGA 224 Query: 277 RALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEP 336 L P R + LI N + + + S CL Sbjct: 225 PPLCDMHP----------------MRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNH 268 Query: 337 KSRPTMDQVVRA 348 RP +Q+++ Sbjct: 269 SQRPATEQLMKH 280 >4D28-A nrPDB Length = 446 Score = 214 bits (545), Expect = 6e-56, Method: Composition-based stats. Identities = 64/286 (22%), Positives = 108/286 (37%), Gaps = 39/286 (13%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR---EWLTEIN 123 + IGEG F V TG +A+K + + +R + EI+ Sbjct: 11 YEVGRTIGEGTFAKV---------KFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREIS 61 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 + + HPN+V+L +V EF+ G L + + +G + Sbjct: 62 IMKIVRHPNIVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESR----KYFQQ 117 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 +A HS V +RD+K N+LLD + N K+SDFGL+ G + GT Sbjct: 118 LVDAVAHCHSK--GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEG--VELLNDTCGTP 173 Query: 244 GYAAPEYMSSGHLN-ARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 Y APE +S + + +D++S GV+L IL+G ++ A Sbjct: 174 NYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEF------ 227 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 P + + + + L PK+R + + + Sbjct: 228 ------------DCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKD 261 >3VN9-A nrPDB Length = 340 Score = 214 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 70/333 (21%), Positives = 127/333 (38%), Gaps = 36/333 (10%) Query: 37 AAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKP 96 T L S S ++ + P +G G +G V K Sbjct: 23 PQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEK---------MRHV 73 Query: 97 GTGLVIAVKKLNQE-GFQGHREWLTEINY-LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQ 154 +G ++AVK++ Q + L +++ + + P V G + + E M Sbjct: 74 PSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMD 133 Query: 155 KGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY 214 SL+ + + +P + +A+ K L LHS + VI+RD+K SN+L++A Sbjct: 134 T-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK-LSVIHRDVKPSNVLINALG 191 Query: 215 NAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM----SSGHLNARSDVYSFGVLLL 270 K+ DFG++ S T G Y APE + + + +SD++S G+ ++ Sbjct: 192 QVKMCDFGISGYLVD---SVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMI 248 Query: 271 EILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQ 330 E+ + D W P+ ++V+ +L E Q Sbjct: 249 ELAILRFPYD-----------SWGTPF-QQLKQVVEEPSPQLPADKFSAE---FVDFTSQ 293 Query: 331 CLSFEPKSRPTMDQVVRA-LQQLQDNLGKPSQT 362 CL K RPT ++++ L ++ G + Sbjct: 294 CLKKNSKERPTYPELMQHPFFTLHESKGTDVAS 326 >5NGU-A nrPDB Length = 381 Score = 213 bits (543), Expect = 9e-56, Method: Composition-based stats. Identities = 78/328 (23%), Positives = 131/328 (39%), Gaps = 48/328 (14%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-REWLTEINY 124 + S IGEG +G V + + + + +A+KK++ Q + + L EI Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVR---------VAIKKISPFEHQTYCQRTLREIKI 93 Query: 125 LGQLSHPNLVKLIGYC-----LEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 L + H N++ + + + +V + M+ L L + L Sbjct: 94 LLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMET-DLYKLLK-----TQHLSNDHICY 147 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG-PMGDLSYVSTR 238 +GL ++HS V++RD+K SN+LL+ + K+ DFGLAR P D + T Sbjct: 148 FLYQILRGLKYIHS--ANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTE 205 Query: 239 VMGTYGYAAPEY-MSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEEN-------- 289 + T Y APE ++S D++S G +L E+LS + + N Sbjct: 206 YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGS 265 Query: 290 ---------LVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP 340 + AR YL S + NRL P + + + L+F P R Sbjct: 266 PSQEDLNCIINLKARNYLLSLPHKNKVPWNRL----FPNADSKALDLLDKMLTFNPHKRI 321 Query: 341 TMDQVVRA--LQQLQDNLGKPSQTNPVK 366 ++Q + L+Q D +P P K Sbjct: 322 EVEQALAHPYLEQYYDPSDEPIAEAPFK 349 >5D9K-A nrPDB Length = 330 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 70/277 (25%), Positives = 117/277 (42%), Gaps = 34/277 (12%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT--EI 122 F V+G+G FG VF + + A+K L + + T E Sbjct: 30 SQFELLKVLGQGSFGKVFLVK------KISGSDARQLYAMKVLKKATLKVRDRVRTKMER 83 Query: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 + L +++HP +VKL + L+ +F++ G L L + + + F +AL Sbjct: 84 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 143 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 L LHS + +IYRD+K NILLD + + KL+DFGL+++ D + GT Sbjct: 144 ----ALDHLHS--LGIIYRDLKPENILLDEEGHIKLTDFGLSKESI--DHEKKAYSFCGT 195 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 Y APE ++ +D +SFGVL+ E+L+G + ++ A+ + Sbjct: 196 VEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGM---- 251 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSR 339 Q+L EA + + P +R Sbjct: 252 -----------PQFLSPEAQSLLRMLF---KRNPANR 274 >6GU6-A nrPDB Length = 302 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 67/300 (22%), Positives = 120/300 (40%), Gaps = 29/300 (9%) Query: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG--HREWLT 120 + ++ IGEG +G V+KG TG V+A+KK+ E + + Sbjct: 5 SMEDYTKIEKIGEGTYGVVYKG---------RHKTTGQVVAMKKIRLESEEEGVPSTAIR 55 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 EI+ L +L HPN+V L ++D L++EF+ L+ +L + + L + Sbjct: 56 EISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPP-GQYMDSSLVKSY 113 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 +G+ F HS +V++RD+K N+L+D KL+DFGLAR + Y T + Sbjct: 114 LYQILQGIVFCHSR--RVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVY--THEV 169 Query: 241 GTYGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSGKRALDHNRPAKEE----------- 288 T Y +PE + + D++S G + E+ + K + + Sbjct: 170 VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPN 229 Query: 289 NLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 N V L + ++ + + L ++P R + + Sbjct: 230 NEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNH 289 >6HXF-B nrPDB Length = 302 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 65/301 (21%), Positives = 121/301 (40%), Gaps = 42/301 (13%) Query: 59 ELKLATRNFRPDSV------IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF 112 E + R+ P+ V +G+G FG V+K E TG + A K + + Sbjct: 7 EYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKE---------TGALAAAKVIETKSE 57 Query: 113 QGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPL 172 + +++ EI L HP +VKL+G D ++ EF G+++ + + L Sbjct: 58 EELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLE---LDRGL 114 Query: 173 PWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDL 232 V + L FLHS ++I+RD+KA N+L+ + + +L+DFG++ Sbjct: 115 TEPQIQVVCRQMLEALNFLHSK--RIIHRDLKAGNVLMTLEGDIRLADFGVSAKNL--KT 170 Query: 233 SYVSTRVMGTYGYAAPEY-----MSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE 287 +GT + APE M + ++D++S G+ L+E+ + P + Sbjct: 171 LQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRV 230 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 + + P + +V L P++RP+ Q++ Sbjct: 231 LLKIAKSDP---------------PTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLE 275 Query: 348 A 348 Sbjct: 276 H 276 >3SOA-A nrPDB Length = 444 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 61/288 (21%), Positives = 107/288 (37%), Gaps = 32/288 (11%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEIN 123 T ++ +G+G F V + + + ++I KKL+ Q E Sbjct: 10 TEEYQLFEELGKGAFSVVRRC----VKVLAGQEYAAMIINTKKLSARDHQKLE---REAR 62 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 L HPN+V+L E+ H L+++ + G L + R Y + + Sbjct: 63 ICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEA----DASHCIQQ 118 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYN---AKLSDFGLARDGPMGDLSYVSTRVM 240 + + LH + V++R++K N+LL + KL+DFGLA + ++ Sbjct: 119 ILEAV--LHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWF--GFA 174 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 GT GY +PE + D+++ GV+L +L G D R Y Sbjct: 175 GTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDE---------DQHRLYQQI 225 Query: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 K DT + + L+ P R T + ++ Sbjct: 226 KAGAYDFPSPEWDT-----VTPEAKDLINKMLTINPSKRITAAEALKH 268 >5LOH-A nrPDB Length = 341 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 71/339 (20%), Positives = 123/339 (36%), Gaps = 49/339 (14%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH---REWLTE 121 F I G FG V+ G G + AVK + + + E Sbjct: 36 EEFSIVKPISRGAFGKVYLGQKG-----------GKLYAVKVVKKADMINKNMTHQVQAE 84 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 + L P +V L + LV E++ G +++ L G + + + V Sbjct: 85 RDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMA----VKYI 140 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS----YVST 237 + A L +LH +I+RD+K N+L+ + + KL+DFGL++ D++ + Sbjct: 141 SEVALALDYLHRH--GIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTR 198 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK-EENLVDWARP 296 GT Y APE + D ++ GV L E L+G + P + +N++ P Sbjct: 199 TFCGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIP 258 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA-LQQLQDN 355 + + K L + A + L+ + R M ++ R L D Sbjct: 259 WPEGEEK-------------LSDNAQSAVEIL---LTIDDTKRAGMKELKRHPLFSDVDW 302 Query: 356 LGKPSQTNPVKDTKKLGFKTGTTKSSEKRFTQKPFGRHL 394 QT P ++ F + +HL Sbjct: 303 ENLQHQTMPFIPQPD-------DETDTSYFEARNTAQHL 334 >3HDN-A nrPDB Length = 373 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 110/299 (36%), Gaps = 43/299 (14%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 + +F VIG+G FG V L + AVK L ++ +E Sbjct: 31 SNPHAKPSDFHFLKVIGKGSFGKV---------LLARHKAEEVFYAVKVLQKKAILKKKE 81 Query: 118 ---WLTEINYL-GQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLP 173 ++E N L + HP LV L + V +++ G L HL R + +P Sbjct: 82 EKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRA 141 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 F A + A L +LHS + ++YRD+K NILLD+ + L+DFGL ++ + + Sbjct: 142 RF----YAAEIASALGYLHS--LNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNST 195 Query: 234 YVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDW 293 ++ GT Y APE + + D + G +L E+L G A+ + + Sbjct: 196 --TSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN 253 Query: 294 ARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP----TMDQVVRA 348 Q P + L + R ++ Sbjct: 254 K------------------PLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSH 294 >5F9E-A nrPDB Length = 353 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 75/316 (23%), Positives = 122/316 (38%), Gaps = 53/316 (16%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW 118 ++KL +F ++G+G FG VF + T A+K L ++ + Sbjct: 13 QIKLKIEDFELHKMLGKGSFGKVFLAEFKK---------TNQFFAIKALKKDVVLMDDDV 63 Query: 119 ---LTEINYLGQ-LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPW 174 + E L HP L + E+ V E++ G L H+ + Sbjct: 64 ECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRAT 123 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSY 234 F + L GL FLHS ++YRD+K NILLD D + K++DFG+ ++ +GD Sbjct: 124 FYAAEIIL----GLQFLHSK--GIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDA-- 175 Query: 235 VSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWA 294 + GT Y APE + N D +SFGVLL E+L G+ + + + Sbjct: 176 KTNEFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI--- 232 Query: 295 RPYLTSKRKVLLIVDNRLDTQYLPEEA-VRMASVAVQCLSFEPKSR----------PTMD 343 R+D + P + V+ EP+ R P Sbjct: 233 ----------------RMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFR 276 Query: 344 QVVRALQQLQDNLGKP 359 ++ ++L+ P Sbjct: 277 EINW--EELERKEIDP 290 >3LIJ-A nrPDB Length = 494 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 58/287 (20%), Positives = 109/287 (37%), Gaps = 38/287 (13%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ--GHREWLTEINY 124 ++ +G G +G V T + A+K + + + + L E+ Sbjct: 39 YQRVKKLGSGAYGEVLLC---------RDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAV 89 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 L L HPN++KL + + + LV E + G L + + R + + + Sbjct: 90 LKLLDHPNIMKLYDFFEDKRNYYLVMECYKGGELFDEIIHRMKFNE----VDAAVIIKQV 145 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 G+ +LH +++RD+K N+LL++ D K+ DFGL+ + +G Sbjct: 146 LSGVTYLHKH--NIVHRDLKPENLLLESKEKDALIKIVDFGLSAVF---ENQKKMKERLG 200 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK 301 T Y APE + + + DV+S GV+L +L+G + V+ + S Sbjct: 201 TAYYIAPEVL-RKKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSP 259 Query: 302 RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + Q L F+ + R + Q + Sbjct: 260 EWK--------------NVSEGAKDLIKQMLQFDSQRRISAQQALEH 292 >1FOT-A nrPDB Length = 318 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 75/340 (22%), Positives = 138/340 (40%), Gaps = 59/340 (17%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE---GFQGHRE 117 K + ++F+ +G G FG V G A+K L +E + Sbjct: 2 KYSLQDFQILRTLGTGSFGRVH---------LIRSRHNGRYYAMKVLKKEIVVRLKQVEH 52 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 E L ++HP ++++ G + + ++ ++++ G L + L + + P+ F Sbjct: 53 TNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYA 112 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 V L L +LHS +IYRD+K NILLD + + K++DFG A+ P V+ Sbjct: 113 AEVCL----ALEYLHSKD--IIYRDLKPENILLDKNGHIKITDFGFAKYVPD-----VTY 161 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY 297 + GT Y APE +S+ N D +SFG+L+ E+L+G + K + A Sbjct: 162 TLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNA--- 218 Query: 298 LTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSR--------------PTMD 343 + ++ P + + + ++ + R P Sbjct: 219 ---------------ELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFK 263 Query: 344 QVVRALQQLQDNLGKPSQTNPVKDTKKLGFKTGTTKSSEK 383 +VV + L N+ P + P++ + G + K E+ Sbjct: 264 EVVWE-KLLSRNIETPYEP-PIQQGQ--GDTSQFDKYPEE 299 >4WNO-A nrPDB Length = 287 Score = 211 bits (537), Expect = 5e-55, Method: Composition-based stats. Identities = 62/231 (26%), Positives = 96/231 (41%), Gaps = 27/231 (11%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL-TEINY 124 F +IG G F VFKG + L +AVK +N++ + L EI Sbjct: 19 EFSRKDLIGHGAFAVVFKGRH--------RAAHDLEVAVKCINKKNLAKSQTLLGKEIKI 70 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 L +L H N+V L + LV E+ G L ++L L Sbjct: 71 LKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRT----LSEDTIRLFLQQI 126 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADY---------NAKLSDFGLARDGPMGDLSYV 235 A + LHS +I+RD+K NILL K++DFG AR + Sbjct: 127 AGAMRLLHSK--GIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNM---M 181 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK 286 + + G+ Y APE + S H + ++D++S G ++ + L+GK + P Sbjct: 182 AATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD 232 >4QTB-A nrPDB Length = 380 Score = 211 bits (536), Expect = 5e-55, Method: Composition-based stats. Identities = 73/327 (22%), Positives = 125/327 (38%), Gaps = 48/327 (14%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH-REWLTEINY 124 + IGEG +G V + +A+KK++ Q + + L EI Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTR---------VAIKKISPFEHQTYCQRTLREIQI 92 Query: 125 LGQLSHPNLVKLIGYCLEDE-----HRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 L + H N++ + +V + M+ L L + L Sbjct: 93 LLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYKLLK-----SQQLSNDHICY 146 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR-DGPMGDLSYVSTR 238 +GL ++HS V++RD+K SN+L++ + K+ DFGLAR P D + T Sbjct: 147 FLYQILRGLKYIHS--ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE 204 Query: 239 VMGTYGYAAPEY-MSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEEN-------- 289 + T Y APE ++S D++S G +L E+LS + + N Sbjct: 205 YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGS 264 Query: 290 ---------LVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP 340 + AR YL S + +L P+ + + + L+F P R Sbjct: 265 PSQEDLNCIINMKARNYLQSLPSKTKVAWAKL----FPKSDSKALDLLDRMLTFNPNKRI 320 Query: 341 TMDQVVRA--LQQLQDNLGKPSQTNPV 365 T+++ + L+Q D +P P Sbjct: 321 TVEEALAHPYLEQYYDPTDEPVAEEPF 347 >2JAM-A nrPDB Length = 304 Score = 211 bits (536), Expect = 6e-55, Method: Composition-based stats. Identities = 58/288 (20%), Positives = 104/288 (36%), Gaps = 36/288 (12%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEIN 123 + F V+G G F VF + TG + A+K + + EI Sbjct: 8 RKTFIFMEVLGSGAFSEVF---------LVKQRLTGKLFALKCIKKSPAFRDSSLENEIA 58 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 L ++ H N+V L H LV + + G L + + RG Y + V Sbjct: 59 VLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEK----DASLVIQQ 114 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILL---DADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 + +LH + +++RD+K N+L + + ++DFGL++ G + + Sbjct: 115 VLSAVKYLHEN--GIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNG----IMSTAC 168 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 GT GY APE ++ + D +S GV+ +L G +K + S Sbjct: 169 GTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFES 228 Query: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + + L +P R T ++ + Sbjct: 229 --------------PFWDDISESAKDFICHLLEKDPNERYTCEKALSH 262 >5YKS-A nrPDB Length = 377 Score = 211 bits (536), Expect = 6e-55, Method: Composition-based stats. Identities = 49/286 (17%), Positives = 103/286 (36%), Gaps = 39/286 (13%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ--GHREWLTEINY 124 + D +G G F V TG +AVK +++ E+ Sbjct: 37 YDLDKTLGRGHFAVVKLA---------RHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRC 87 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 + + HPN+V+L L+ E G + +++ + + L L Sbjct: 88 MKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHE---EGLNEDLAKKYFAQI 144 Query: 185 AKGLAFLHSDPVKVIYRDIKASN-ILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 +++ H + V++RD+K N + + KL+DFG + G T G+ Sbjct: 145 VHAISYCH--KLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGK---KLTTSCGSL 199 Query: 244 GYAAPEYMSSGHLN-ARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 Y+APE + + D++S GV+L ++ G+ ++ ++ + + Sbjct: 200 AYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTV---- 255 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + + L +PK R +++++ Sbjct: 256 --------------PSHVSKECKDLITRMLQRDPKRRASLEEIENH 287 >1U5R-A nrPDB Length = 348 Score = 210 bits (534), Expect = 9e-55, Method: Composition-based stats. Identities = 76/324 (23%), Positives = 124/324 (38%), Gaps = 47/324 (14%) Query: 32 SSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTL 91 + L V F + + F IG G FG V+ Sbjct: 23 QGAMDPMPAGGRAGSLKDPDVAELFFKD--DPEKLFSDLREIGHGSFGAVYFA------- 73 Query: 92 TPTKPGTGLVIAVKKLN---QEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLL 148 V+A+KK++ ++ + ++ + E+ +L +L HPN ++ G L + L Sbjct: 74 --RDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWL 131 Query: 149 VYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNI 208 V E+ GS + L KPL V A +GLA+LHS +I+RD+KA NI Sbjct: 132 VMEYC-LGSASDLLEVHK---KPLQEVEIAAVTHGALQGLAYLHSH--NMIHRDVKAGNI 185 Query: 209 LLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMS---SGHLNARSDVYSF 265 LL KL DFG A + +GT + APE + G + + DV+S Sbjct: 186 LLSEPGLVKLGDFGSASIMAP------ANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSL 239 Query: 266 GVLLLEILSGKRA-LDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRM 324 G+ +E+ K + N + ++ P L S + Sbjct: 240 GITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGH-----------------WSEYF 282 Query: 325 ASVAVQCLSFEPKSRPTMDQVVRA 348 + CL P+ RPT + +++ Sbjct: 283 RNFVDSCLQKIPQDRPTSEVLLKH 306 >6QAU-A nrPDB Length = 280 Score = 210 bits (534), Expect = 9e-55, Method: Composition-based stats. Identities = 62/244 (25%), Positives = 101/244 (41%), Gaps = 27/244 (11%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL-T 120 + + ++G G F VF+G + T +A+K +N++ + L Sbjct: 8 VGDFEYSKRDLVGHGAFAVVFRGRH--------RQKTDWEVAIKSINKKNLSKSQILLGK 59 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 EI L +L H N+V L LV E+ G L ++L +G L Sbjct: 60 EIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGT----LSEDTIRVF 115 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLD---------ADYNAKLSDFGLARDGPMGD 231 A + LHS +I+RD+K NILL + K++DFG AR Sbjct: 116 LHQIAAAMRILHSK--GIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNM 173 Query: 232 LSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 ++ + G+ Y APE + S H +A++D++S G ++ + L GK N P Sbjct: 174 ---MAADLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFY 230 Query: 292 DWAR 295 + R Sbjct: 231 EKNR 234 >4RA4-A nrPDB Length = 355 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 64/262 (24%), Positives = 120/262 (45%), Gaps = 22/262 (8%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW-- 118 ++ +F V+G+G FG V + GT + A+K L ++ + Sbjct: 16 RVKLTDFNFLMVLGKGSFGKVMLA---------DRKGTEELYAIKILKKDVVIQDDDVEC 66 Query: 119 -LTEINYLGQLSHP-NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 + E L L P L +L + V E++ G L H+ + G + +P F Sbjct: 67 TMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFY 126 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 +++ GL FLH +IYRD+K N++LD++ + K++DFG+ ++ M ++ + Sbjct: 127 AAEISI----GLFFLHKR--GIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVT--T 178 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK-EENLVDWAR 295 GT Y APE ++ D +++GVLL E+L+G+ D + +++++ Sbjct: 179 RTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNV 238 Query: 296 PYLTSKRKVLLIVDNRLDTQYL 317 Y S K + + L T++ Sbjct: 239 SYPKSLSKEAVSICKGLMTKHP 260 >4NEU-A nrPDB Length = 333 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 78/333 (23%), Positives = 141/333 (42%), Gaps = 42/333 (12%) Query: 52 VKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEG 111 + N +K+ + +F + + GGFG V + L K Sbjct: 11 QPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKG--------PNC 62 Query: 112 FQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKP 171 + + L E + +L H +VKL+G +E+ LV E+M+KG+L + L + Sbjct: 63 IEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMST--- 119 Query: 172 LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR------ 225 P ++ + L+ +G+ +LH VI++D+K NIL+D D++ K++D GLA Sbjct: 120 -PLSVKGRIILEIIEGMCYLH--GKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSK 176 Query: 226 -----DGPMGDLSYVSTRVMGTYGYAAPEYMS--SGHLNARSDVYSFGVLLLEILSGKRA 278 + ++ + + GT Y APE+++ + +SDVYSF V+L I + K Sbjct: 177 LNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEP 236 Query: 279 LDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVR-MASVAVQCLSFEPK 337 ++ ++ + + NR D + E R + S+ C P+ Sbjct: 237 YENAICEQQLIMCIKS--------------GNRPDVDDITEYCPREIISLMKLCWEANPE 282 Query: 338 SRPTMDQVVRALQQLQDNLGKPSQTNPVKDTKK 370 +RPT + + + + S VK KK Sbjct: 283 ARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKK 315 >2GCD-A nrPDB Length = 309 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 73/289 (25%), Positives = 118/289 (40%), Gaps = 45/289 (15%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN---QEGFQGHREWLTEIN 123 F IG G FG V+ V+A+KK++ ++ + ++ + E+ Sbjct: 17 FSDLREIGHGSFGAVYFA---------RDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVR 67 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 +L +L HPN ++ G L + LV E+ GS + L KPL V Sbjct: 68 FLQKLRHPNTIQYRGCYLREHTAWLVMEYC-LGSASDLLEVHK---KPLQEVEIAAVTHG 123 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 A +GLA+LHS +I+RD+KA NILL KL DFG A + +GT Sbjct: 124 ALQGLAYLHSH--NMIHRDVKAGNILLSEPGLVKLGDFGSASIMAP------ANSFVGTP 175 Query: 244 GYAAPEYMS---SGHLNARSDVYSFGVLLLEILSGKRA-LDHNRPAKEENLVDWARPYLT 299 + APE + G + + DV+S G+ +E+ K + N + ++ P L Sbjct: 176 YWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQ 235 Query: 300 SKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 S + + CL P+ RPT + +++ Sbjct: 236 SGH-----------------WSEYFRNFVDSCLQKIPQDRPTSEVLLKH 267 >4L68-A nrPDB Length = 340 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 99/314 (31%), Positives = 163/314 (51%), Gaps = 20/314 (6%) Query: 47 LSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKK 106 L P+ +L AT NF +++I G +K L + G +AVK Sbjct: 22 LFQKPLVKVKLGDLMAATNNFNSENIIVSTRTGTTYKALLPD----------GSALAVKH 71 Query: 107 LNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRG 166 L+ G RE+ E+N L +L H NL L+G+C+ +E + LVY++M G+L + L Sbjct: 72 LSTCKL-GEREFRYEMNQLWELRHSNLAPLLGFCVVEEEKFLVYKYMSNGTLHSLLDSNR 130 Query: 167 AYFKPLPWFLRVNVALDAAKGLAFLHSDP-VKVIYRDIKASNILLDADYNAKLSDFGLAR 225 L W R + L AA+GLA+LH +++++I +S IL+D D++A++ D GLAR Sbjct: 131 G---ELDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLAR 187 Query: 226 DGPMGDLSYVS--TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNR 283 D + S T +G +GY APEY ++ + + DVY GV+LLE+ +G +A+ Sbjct: 188 LMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLKGDVYGLGVVLLELATGLKAVGGE- 246 Query: 284 PAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMD 343 + +LVDW + L S ++ D + + EE + +A+ C+S PK R +M Sbjct: 247 -GFKGSLVDWVKQ-LESSGRIAETFDENIRGKGHDEEISKFVEIALNCVSSRPKERWSMF 304 Query: 344 QVVRALQQLQDNLG 357 Q ++L+ + + G Sbjct: 305 QAYQSLKAIAEKQG 318 >6BDL-A nrPDB Length = 347 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 64/269 (23%), Positives = 108/269 (40%), Gaps = 20/269 (7%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE---W 118 L +F +G GGFG V L K A+K L + R+ Sbjct: 31 LKLSDFNIIDTLGVGGFGRV--------ELVQLKSEESKTFAMKILKKRHIVDTRQQEHI 82 Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 +E + +V+L + ++ ++ E G L L RG++ F Sbjct: 83 RSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTA 142 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR 238 V + A+LHS +IYRD+K N++LD AKL DFG A+ G ++ Sbjct: 143 CV----VEAFAYLHSK--GIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTW---T 193 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 GT Y APE + + + +D +S G+L+ E+L+G P K N++ + Sbjct: 194 FCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMI 253 Query: 299 TSKRKVLLIVDNRLDTQYLPEEAVRMASV 327 +K+ N + + R+ ++ Sbjct: 254 EFPKKIAKNAANLIKKLCRDNPSERLGNL 282 >1V0B-A nrPDB Length = 288 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 119/299 (39%), Gaps = 32/299 (10%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN--QEGFQGHREWLTE 121 + IGEG +G V+K + G A+KK+ +E + E Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQNNY----------GETFALKKIRLEKEDEGIPSTTIRE 50 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 I+ L +L H N+VKL + +LV+E + L+ L + + + Sbjct: 51 ISILKELKHSNIVKLYDVIHTKKRLVLVFEHLD-QDLKKLLDVCEGGLESVT---AKSFL 106 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 L G+A+ H +V++RD+K N+L++ + K++DFGLAR + Y T + Sbjct: 107 LQLLNGIAYCHDR--RVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKY--THEVV 162 Query: 242 TYGYAAPEYMS-SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 T Y AP+ + S + D++S G + E+++G A + + S Sbjct: 163 TLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNS 222 Query: 301 KRKVLLIVDNRLDT-----QYLPEEAV------RMASVAVQCLSFEPKSRPTMDQVVRA 348 K + + D + LP E+ + + L +P R T Q + Sbjct: 223 KNWPNVTELPKYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEH 281 >3D2K-A nrPDB Length = 272 Score = 209 bits (532), Expect = 2e-54, Method: Composition-based stats. Identities = 65/303 (21%), Positives = 123/303 (40%), Gaps = 41/303 (13%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG---HRE 117 + +F +G+G FG V+ + + ++A+K L + + + Sbjct: 8 QWTLEDFDIGRPLGKGKFGNVYLA---------RERQSKFILALKVLFKTQLEKAGVEHQ 58 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 E+ L HPN+++L GY + L+ E+ G++ L + + + Sbjct: 59 LRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRT---- 114 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 + A L++ HS +VI+RDIK N+LL ++ K++DFG + P S T Sbjct: 115 ATYITELANALSYCHSK--RVIHRDIKPENLLLGSNGELKIADFGWSVHAP----SSRRT 168 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY 297 + GT Y PE + + + D++S GVL E L G + + Y Sbjct: 169 TLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHT-------------Y 215 Query: 298 LTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLG 357 + R++ +R++ + + + L R T+ +V+ ++ N Sbjct: 216 QETYRRI-----SRVEFTFPDFVTEGARDLISRLLKHNASQRLTLAEVLEHPW-IKANSS 269 Query: 358 KPS 360 KPS Sbjct: 270 KPS 272 >4YZB-A nrPDB Length = 491 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 65/337 (19%), Positives = 130/337 (38%), Gaps = 40/337 (11%) Query: 38 AAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPG 97 + ++ + L++TP F + + ++ V+G+G FG V Sbjct: 4 SPAASKSDKLAATPG-MFVQHSTAAFSDRYKGQRVLGKGSFGEVILC---------KDKV 53 Query: 98 TGLVIAVKKLNQEGFQGHREWLTEINYLGQL---SHPNLVKLIGYCLEDEHRLLVYEFMQ 154 TG AVK +++ + + + + L HPN++KL + + + LV E Sbjct: 54 TGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDHPNIMKLYEFFEDKGYFYLVTEVYT 113 Query: 155 KGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDA-- 212 G L + + R + + + G+ ++H + K+++RD+K N+LL+ Sbjct: 114 GGELFDEIISRKRFSE----VDAARIIRQVLSGITYMHKN--KIVHRDLKPENLLLENKR 167 Query: 213 -DYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLE 271 D N ++ DFGL+ + + +GT Y APE + G + + DV+S GV+L Sbjct: 168 KDANIRIIDFGLSTHF---ESTKKMKDKIGTAYYIAPEVLH-GTYDEKCDVWSTGVILYI 223 Query: 272 ILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQC 331 +LSG + V+ + D + + + + Sbjct: 224 LLSGCPPFNGANEFDILKKVEKGKFTF--------------DLPQWKKVSEPAKDLIRKM 269 Query: 332 LSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVKDT 368 L++ P R + + + S P ++ Sbjct: 270 LAYVPTMRISARDALEHEWLKTTDAATDSIDVPSLES 306 >2F9G-A nrPDB Length = 353 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 74/354 (20%), Positives = 130/354 (36%), Gaps = 52/354 (14%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ-EGFQGHREWLTEI 122 + +F+ S++GEG +G V T TG ++A+KK+ + L EI Sbjct: 10 SSDFQLKSLLGEGAYGVVCSA---------THKPTGEIVAIKKIEPFDKPLFALRTLREI 60 Query: 123 NYLGQLSHPNLVKLI-----GYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 L H N++ + ++ E MQ L + + + +F+ Sbjct: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQT-DLHRVISTQMLSDDHIQYFI- 118 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR--------DGPM 229 + + LH VI+RD+K SN+L++++ + K+ DFGLAR + Sbjct: 119 ----YQTLRAVKVLH--GSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEP 172 Query: 230 GDLSYVSTRVMGTYGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSGKRALDH------- 281 T + T Y APE M + + DV+S G +L E+ + Sbjct: 173 TGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQL 232 Query: 282 -------NRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSF 334 P + +L P K L + + P + + + L F Sbjct: 233 LLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVF 292 Query: 335 EPKSRPTMDQVVRA--LQQLQDNLGKPSQTNPVKDT---KKLGFKTGTTKSSEK 383 +P R T + + LQ D +P + P+ + + TTK +K Sbjct: 293 DPAKRITAKEALEHPYLQTYHDPNDEP-EGEPIPPSFFEFDHYKEALTTKDLKK 345 >1VZO-A nrPDB Length = 355 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 79/323 (24%), Positives = 130/323 (40%), Gaps = 42/323 (13%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF----QGHR 116 K+ NF V+G G +G VF + TG + A+K L + + Sbjct: 50 KVGIENFELLKVLGTGAYGKVFLVR------KISGHDTGKLYAMKVLKKATIVQKAKTTE 103 Query: 117 EWLTEINYLGQLS-HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 TE L + P LV L + L+ +++ G L HL +R + + Sbjct: 104 HTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQI 163 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 + L L LH + +IYRDIK NILLD++ + L+DFGL+++ + D + Sbjct: 164 YVGEIVL----ALEHLH--KLGIIYRDIKLENILLDSNGHVVLTDFGLSKEF-VADETER 216 Query: 236 STRVMGTYGYAAPEYMSSGH--LNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDW 293 + GT Y AP+ + G + D +S GVL+ E+L+G + + + Sbjct: 217 AYDFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQ--AEI 274 Query: 294 ARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSR----PT-MDQVVRA 348 +R L S + Y E + + + L +PK R P D++ Sbjct: 275 SRRILKS------------EPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEH 322 Query: 349 L--QQLQ-DNLGKPSQTNPVKDT 368 L Q++ D+L P K Sbjct: 323 LFFQKINWDDLAAKKVPAPFKPV 345 >6DTL-A nrPDB Length = 364 Score = 208 bits (528), Expect = 5e-54, Method: Composition-based stats. Identities = 78/357 (21%), Positives = 130/357 (36%), Gaps = 43/357 (12%) Query: 52 VKSFTFNELKLATRNFRP-DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ- 109 ++ F + T ++P IG+G +G V E T +A+KK+ Sbjct: 16 IQYNIFGNIFEVTAKYKPPIMPIGKGAYGIVCSAMNSE---------TNESVAIKKIANA 66 Query: 110 -EGFQGHREWLTEINYLGQLSHPNLVKLIGYCLED-----EHRLLVYEFMQKGSLENHLF 163 + + L EI L + H N+V + + YE M L + Sbjct: 67 FDNKIDAKRTLREIKLLRHMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT-DLHQIIR 125 Query: 164 RRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGL 223 A + +GL ++HS V++RD+K SN+LL+A+ + K+ DFGL Sbjct: 126 SNQALSEEH----CQYFLYQILRGLKYIHS--ANVLHRDLKPSNLLLNANCDLKICDFGL 179 Query: 224 ARDGPMGDLSYVSTRVMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRALDHN 282 AR D T + T Y APE ++S A DV+S G + +E++ K Sbjct: 180 ARVTSESDF---MTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGR 236 Query: 283 RPAKEENLVDWARPYLTSKR------------KVLLIVDNRLDTQYLPEEAVRMASVAVQ 330 + L+ + + + L + T P + + Sbjct: 237 DHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEK 296 Query: 331 CLSFEPKSRPTMDQVVRA--LQQLQDNLGKPSQTNPVK-DTKKLGFKTGTTKSSEKR 384 L+F+P+ R T+ + L L D +P T P D + K R Sbjct: 297 MLTFDPRRRITVLDALAHPYLNSLHDISDEPECTIPFNFDFENHALSEEQMKELIYR 353 >2W4O-A nrPDB Length = 349 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 71/332 (21%), Positives = 130/332 (39%), Gaps = 44/332 (13%) Query: 20 SDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFG 79 +LY S+SS +S+ A + + + + F +S +G G Sbjct: 16 ENLYFQSMSSVTASAAPGTASLVPDYWIDGSNRDALS--------DFFEVESELGRGATS 67 Query: 80 CVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGY 139 V++ + GT A+K L + + TEI L +LSHPN++KL Sbjct: 68 IVYRC---------KQKGTQKPYALKVLKKTV--DKKIVRTEIGVLLRLSHPNIIKLKEI 116 Query: 140 CLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVI 199 LV E + G L + + +G Y + + + +A+LH + ++ Sbjct: 117 FETPTEISLVLELVTGGELFDRIVEKGYYSER----DAADAVKQILEAVAYLHEN--GIV 170 Query: 200 YRDIKASNILLDA---DYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHL 256 +RD+K N+L D K++DFGL++ + + + V GT GY APE + Sbjct: 171 HRDLKPENLLYATPAPDAPLKIADFGLSK---IVEHQVLMKTVCGTPGYCAPEILRGCAY 227 Query: 257 NARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQY 316 D++S G++ +L G R R++L + + Sbjct: 228 GPEVDMWSVGIITYILLCGFEPFYDE------------RGDQFMFRRILNCEYYFISP-W 274 Query: 317 LPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 E ++ + + + +PK R T Q ++ Sbjct: 275 WDEVSLNAKDLVRKLIVLDPKKRLTTFQALQH 306 >4APC-A nrPDB Length = 350 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 57/287 (19%), Positives = 114/287 (39%), Gaps = 34/287 (11%) Query: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN--QEGFQGHREWLT 120 + + IGEG FG + G +K++N + + E Sbjct: 22 SMEKYVRLQKIGEGSFGK---------AILVKSTEDGRQYVIKEINISRMSSKEREESRR 72 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 E+ L + HPN+V+ E+ +V ++ + G L + + ++ Sbjct: 73 EVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVL--FQEDQILDW 130 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 + L +H K+++RDIK+ NI L D +L DFG+AR + ++ + Sbjct: 131 FVQICLALKHVHDR--KILHRDIKSQNIFLTKDGTVQLGDFGIAR--VLNSTVELARACI 186 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 GT Y +PE + N +SD+++ G +L E+ + K A + S Sbjct: 187 GTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAG-----------------S 229 Query: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 + ++L + + + + S+ Q P+ RP+++ ++ Sbjct: 230 MKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILE 276 >1G3N-A nrPDB Length = 326 Score = 207 bits (527), Expect = 7e-54, Method: Composition-based stats. Identities = 72/324 (22%), Positives = 129/324 (39%), Gaps = 42/324 (12%) Query: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR--EWLT 120 A + + + IGEG +G VFK G +A+K++ + + + Sbjct: 9 ADQQYECVAEIGEGAYGKVFKARDL--------KNGGRFVALKRVRVQTGEEGMPLSTIR 60 Query: 121 EINYLGQLS---HPNLVKLIGYCL-----EDEHRLLVYEFMQKGSLENHLFRRGAYFKPL 172 E+ L L HPN+V+L C + LV+E + L +L + + Sbjct: 61 EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD-QDLTTYLDK--VPEPGV 117 Query: 173 PWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDL 232 P ++ +GL FLHS +V++RD+K NIL+ + KL+DFGLAR + Sbjct: 118 PTETIKDMMFQLLRGLDFLHSH--RVVHRDLKPQNILVTSSGQIKLADFGLAR---IYSF 172 Query: 233 SYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV- 291 T V+ T Y APE + D++S G + E+ K + + + Sbjct: 173 QMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKIL 232 Query: 292 ---------DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTM 342 DW R + R+ + +++ + + ++CL+F P R + Sbjct: 233 DVIGLPGEEDWPRD-VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISA 291 Query: 343 DQVVRA-----LQQLQDNLGKPSQ 361 + L++ ++NL Sbjct: 292 YSALSHPYFQDLERCKENLDSHLP 315 >3TAC-A nrPDB Length = 361 Score = 207 bits (527), Expect = 7e-54, Method: Composition-based stats. Identities = 63/306 (20%), Positives = 115/306 (37%), Gaps = 37/306 (12%) Query: 51 PVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE 110 P S +++ L + VIG+G F V + E TG AVK ++ Sbjct: 13 PRGSMADDDV-LFEDVYELCEVIGKGPFSVVRRCINRE---------TGQQFAVKIVDVA 62 Query: 111 GFQGH-----REWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR 165 F + E + L HP++V+L+ D +V+EFM L + +R Sbjct: 63 KFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKR 122 Query: 166 GAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN---AKLSDFG 222 + + + L + H + +I+RD+K +LL + N KL FG Sbjct: 123 ADAGFVYSEAVASHYMRQILEALRYCHDN--NIIHRDVKPHCVLLASKENSAPVKLGGFG 180 Query: 223 LARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHN 282 +A +G+ V+ +GT + APE + DV+ GV+L +LSG Sbjct: 181 VA--IQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGT 238 Query: 283 RPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTM 342 + E ++ +++ + + + + L +P R T+ Sbjct: 239 KERLFEGIIKGKY---------------KMNPRQWSHISESAKDLVRRMLMLDPAERITV 283 Query: 343 DQVVRA 348 + + Sbjct: 284 YEALNH 289 >3ZDU-A nrPDB Length = 325 Score = 207 bits (526), Expect = 9e-54, Method: Composition-based stats. Identities = 64/301 (21%), Positives = 114/301 (37%), Gaps = 32/301 (10%) Query: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG-HREWLTE 121 + + +GEG +G V K TG ++A+K + Q ++ + E Sbjct: 1 SMEMYETLGKVGEGSYGTVMKC---------KHKNTGQIVAIKIFYERPEQSVNKIAMRE 51 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 I +L Q H NLV LI + + LV+EF+ L+ Y L Sbjct: 52 IKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQH----YCHGLESKRLRKYL 107 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 + + +LHS+ +I+RDIK NIL+ KL DFG AR Y + Sbjct: 108 FQILRAIDYLHSN--NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIY--DDEVA 163 Query: 242 TYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 T Y APE + D+++ G +++E+ +G L + + + L+ Sbjct: 164 TRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSP 223 Query: 301 KRK-------------VLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 + + + + + P+ +A + CL +P R + ++ Sbjct: 224 HLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLH 283 Query: 348 A 348 Sbjct: 284 H 284 >2J90-A nrPDB Length = 304 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 66/298 (22%), Positives = 114/298 (38%), Gaps = 42/298 (14%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR---- 116 + ++ +G G F V K + GTG A K + + R Sbjct: 22 SMVEDHYEMGEELGSGQFAIVRKC---------RQKGTGKEYAAKFIKKRRLSSSRRGVS 72 Query: 117 --EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPW 174 E E+N L ++ HPN++ L +L+ E + G L + L + + L Sbjct: 73 REEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEK----ESLTE 128 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDA----DYNAKLSDFGLARDGPMG 230 G+ +LHS ++ + D+K NI+L + KL DFG+A G Sbjct: 129 DEATQFLKQILDGVHYLHSK--RIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAG 186 Query: 231 DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENL 290 + + GT + APE ++ L +D++S GV+ +LSG L Sbjct: 187 NE---FKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPF----------L 233 Query: 291 VDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + LT+ + V+ D +Y + + L +PK R T+ Q + Sbjct: 234 GETKQETLTN----ISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEH 287 >3F3Z-A nrPDB Length = 277 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 66/303 (21%), Positives = 112/303 (36%), Gaps = 41/303 (13%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLG 126 + ++ IG G +G V + GT + A KK+ + + + EI + Sbjct: 11 YTLENTIGRGSWGEVKIA---------VQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMK 61 Query: 127 QLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAK 186 L HPN+++L ++ LV E G L + + + + + D Sbjct: 62 SLDHPNIIRLYETFEDNTDIYLVMELCTGGELFERVVHKRVFRE----SDAARIMKDVLS 117 Query: 187 GLAFLHSDPVKVIYRDIKASNILL---DADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 +A+ H + V +RD+K N L D KL DFGLA G + +GT Sbjct: 118 AVAYCH--KLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGK---MMRTKVGTP 172 Query: 244 GYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRK 303 Y +P+ + G D +S GV++ +L G P E ++ T K Sbjct: 173 YYVSPQVLE-GLYGPECDEWSAGVMMYVLLCGYPPFSA--PTDSEVMLKIREGTFTFPEK 229 Query: 304 VLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTN 363 L V + + S+ + L+ PK R T Q + + K ++ Sbjct: 230 DWLNV------------SPQAESLIRRLLTKSPKQRITSLQALEH-----EWFEKQLSSS 272 Query: 364 PVK 366 P Sbjct: 273 PRN 275 >4B6L-A nrPDB Length = 281 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 58/287 (20%), Positives = 105/287 (36%), Gaps = 38/287 (13%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE---GFQGHREWLTE 121 R + ++G+GGF ++ E TG AVK + Q + L E Sbjct: 9 RTYLKGRLLGKGGFARCYEATDTE---------TGSAYAVKVIPQSRVAKPHQREKILNE 59 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 I L H ++V+ + + ++ + E + SL + R +P Sbjct: 60 IELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPE----VRYYL 115 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 GL +LH +++RD+K N + + K+ DFGLA + + G Sbjct: 116 RQILSGLKYLHQR--GILHRDLKLGNFFITENMELKVGDFGLA--ARLEPPEQRKKTICG 171 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK 301 T Y APE + +DV+S G ++ +L G + + + Sbjct: 172 TPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCI---------- 221 Query: 302 RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 ++V + L + L P+ RP++DQ++R Sbjct: 222 KQVHYTLPASLSLP--------ARQLLAAILRASPRDRPSIDQILRH 260 >3A8W-A nrPDB Length = 345 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 74/283 (26%), Positives = 122/283 (43%), Gaps = 32/283 (11%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW--- 118 L ++F VIG G + V L T + A+K + +E + Sbjct: 6 LGLQDFDLLRVIGRGSYAKV---------LLVRLKKTDRIYAMKVVKKELVNDDEDIDWV 56 Query: 119 LTEINYLGQ-LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 TE + Q +HP LV L + V E++ G L H+ R+ + F Sbjct: 57 QTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYS 116 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG-PMGDLSYVS 236 ++L L +LH +IYRD+K N+LLD++ + KL+D+G+ ++G GD + Sbjct: 117 AEISL----ALNYLHER--GIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTT--- 167 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 + GT Y APE + D ++ GVL+ E+++G+ D +N Sbjct: 168 STFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFD--IVGSSDNPDQNTED 225 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSR 339 YL +V+L R+ +V+ ASV L+ +PK R Sbjct: 226 YLF---QVILEKQIRIPRSL----SVKAASVLKSFLNKDPKER 261 >6CQF-A nrPDB Length = 297 Score = 206 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 67/294 (22%), Positives = 114/294 (38%), Gaps = 39/294 (13%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 + ++ +G G +G VFK +G ++A+K + E Sbjct: 12 RDPRDHYDLLQRLGGGTYGEVFKA---------RDKVSGDLVALKMVKMEPDDDVSTLQK 62 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 EI L H N+V G L + + EF GSL++ G+ L V Sbjct: 63 EILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGS----LSELQISYV 118 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 + +GLA+LHS I+RDIK +NIL++ +L+DFG++ +G + Sbjct: 119 CREVLQGLAYLHSQKK--IHRDIKGANILINDAGEVRLADFGIS--AQIGATLARRLAFI 174 Query: 241 GTYGYAAPE---YMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY 297 GT + APE G N D++S G+ +E+ + L P Sbjct: 175 GTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPL------------ 222 Query: 298 LTSKRKVLLIVDNRLDTQYLPEE---AVRMASVAVQCLSFEPKSRPTMDQVVRA 348 R + L+ + L E+ + + L+ PK RP+ +++ Sbjct: 223 ----RVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSH 272 >5WNO-A nrPDB Length = 330 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 64/308 (20%), Positives = 118/308 (38%), Gaps = 28/308 (9%) Query: 68 RPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQ 127 + D +G G FG VF G + +A+K Q E L E + + Sbjct: 25 KLDKKLGAGAFGTVFAGIY----YPKRAKNVKIPVAIKVF-QTDQSQTDEMLEEATNMFR 79 Query: 128 LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 L H NL+K+IG+C+ D+ +V + G+L+N L + L +V A G Sbjct: 80 LRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHK---ENLGAREQVLYCYQIASG 136 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAA 247 + +L + +V++RD+ N+L+ + +++DFGL++ S + A Sbjct: 137 MQYL--EKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLA 194 Query: 248 PEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLTSKRKVLL 306 E S SDV++FGV EI++ G+ S + Sbjct: 195 IEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQG-----------------MSTDSIHN 237 Query: 307 IVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVK 366 + + P + + ++C +PKSRP + + ++ + + Sbjct: 238 FLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKI 297 Query: 367 DTKKLGFK 374 L + Sbjct: 298 SESDLSAE 305 >5WAX-A nrPDB Length = 310 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 65/320 (20%), Positives = 116/320 (36%), Gaps = 37/320 (11%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 + IG G FG G ++AVK + + G + EI Sbjct: 11 DRYELVRDIGSGNFGV---------ARLMRNRADGQLVAVKYI-ERGEKIDENVQREIIN 60 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 L HPN+++ L H +V E+ G L + G + + F Sbjct: 61 HRSLRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARF----FFQQL 116 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDAD--YNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 G+++ HS ++V +RD+K N LLD K+ DFG ++ + +GT Sbjct: 117 ISGVSYCHS--MQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHS---QPKSTVGT 171 Query: 243 YGYAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK 301 Y APE + + + DV+S GV L +L G + P + +N + L + Sbjct: 172 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFED--PDEPKNFRKTIQRILGVQ 229 Query: 302 RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA---LQQLQDNLGK 358 + V + Q + + P +R T+ ++ L+ L +L Sbjct: 230 YSIPDYVHISPECQ----------DLISRIFVANPATRITIPEIRNHPWFLKNLPADLMD 279 Query: 359 PSQTNPVKDTKKLGFKTGTT 378 S + + + ++ Sbjct: 280 DSTMSKQYEEPEQPMQSMDE 299 >4IC8-A nrPDB Length = 442 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 73/364 (20%), Positives = 130/364 (35%), Gaps = 47/364 (12%) Query: 34 STVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTP 93 T A+ +L K+ +F+ + IG G +G V Sbjct: 29 HTAASVAAKNLALL-----KARSFDVTFDVGDEYEIIETIGNGAYGVVSSA--------- 74 Query: 94 TKPGTGLVIAVKKLNQ--EGFQGHREWLTEINYLGQLSHPNLVKLIGY------CLEDEH 145 + TG +A+KK+ + + L E+ L H N++ + E + Sbjct: 75 RRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKS 134 Query: 146 RLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKA 205 +V + M+ L + +PL +GL ++HS +VI+RD+K Sbjct: 135 VYVVLDLMES-DLHQIIHS----SQPLTLEHVRYFLYQLLRGLKYMHS--AQVIHRDLKP 187 Query: 206 SNILLDADYNAKLSDFGLARDG--PMGDLSYVSTRVMGTYGYAAPEYMSS-GHLNARSDV 262 SN+L++ + K+ DFG+AR + Y T + T Y APE M S D+ Sbjct: 188 SNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDL 247 Query: 263 YSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL----------TSKRKVLLIVDNRL 312 +S G + E+L+ ++ + L+ R + + R Sbjct: 248 WSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQ 307 Query: 313 DTQY---LPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA--LQQLQDNLGKPSQTNPVKD 367 + P + S+ + L FEP +R + +R L + D +P P Sbjct: 308 PVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDF 367 Query: 368 TKKL 371 Sbjct: 368 AFDR 371 >4PDS-A nrPDB Length = 347 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 68/327 (20%), Positives = 128/327 (39%), Gaps = 48/327 (14%) Query: 38 AAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPG 97 A K L+S+ S N+ + D V+G+G F V K + Sbjct: 4 ATSKIASPGLTSSTASSMVANKTGIFKDFSIIDEVVGQGAFATVKKA---------IERT 54 Query: 98 TGLVIAVKKLNQEGFQGHRE-WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKG 156 TG +VK +++ G+ + E+ L +L+HP +V+L G+ + E +V EF+ G Sbjct: 55 TGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFYEDTESYYMVMEFVSGG 114 Query: 157 SLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY-- 214 L + + GA + ++ + ++HS + + +RD+K NIL++ D Sbjct: 115 DLMDFVAAHGAVGEDAGR----EISRQILTAIKYIHS--MGISHRDLKPDNILIEQDDPV 168 Query: 215 NAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGH-------------LNARSD 261 K++ FGLA+ G+ S++ T GT Y APE + ++ D Sbjct: 169 LVKITAFGLAK--VQGNGSFMKT-FCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVD 225 Query: 262 VYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEA 321 ++S G L+ IL+G + + + + + + + Sbjct: 226 MWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRI--------------S 271 Query: 322 VRMASVAVQCLSFEPKSRPTMDQVVRA 348 L +P +R T + + Sbjct: 272 EEARDFIDSLLQVDPNNRSTAAKALNH 298 >4U41-A nrPDB Length = 332 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 74/316 (23%), Positives = 124/316 (39%), Gaps = 47/316 (14%) Query: 48 SSTPVKSFT---FNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAV 104 + +P KS + L+ F V+G G +G V+KG TG + A+ Sbjct: 4 NDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKG---------RHVKTGQLAAI 54 Query: 105 KKLNQEGFQGHREWLTEINYLGQLSHP-NLVKLIGYCL------EDEHRLLVYEFMQKGS 157 K ++ + L EIN L + SH N+ G + D+ LV EF GS Sbjct: 55 KVMDVTEDEEEEIKL-EINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGS 113 Query: 158 LENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAK 217 + + + W ++ + +GLA LH VI+RDIK N+LL + K Sbjct: 114 ITDLVKNTKGNTLKEDWI--AYISREILRGLAHLHIH--HVIHRDIKGQNVLLTENAEVK 169 Query: 218 LSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMS-----SGHLNARSDVYSFGVLLLEI 272 L DFG++ + +GT + APE ++ + RSD++S G+ +E+ Sbjct: 170 LVDFGVS--AQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEM 227 Query: 273 LSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCL 332 G L P + L+ P +K + ++ CL Sbjct: 228 AEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEG----------------CL 271 Query: 333 SFEPKSRPTMDQVVRA 348 RP+ +Q+++ Sbjct: 272 VKNYMQRPSTEQLLKH 287 >4YNZ-A nrPDB Length = 342 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 66/329 (20%), Positives = 126/329 (38%), Gaps = 41/329 (12%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH--REWLTEINY 124 +R + +G+G G V G T +A+K +N+E + EI Sbjct: 12 YRLEKTLGKGQTGLVKLG---------IHCVTCQKVAIKIVNREKLSESVLMKVEREIAI 62 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 L + HP+++KL ++ LV E + G L ++L ++G Sbjct: 63 LKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEAR----KFFRQI 118 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYG 244 L F HS + +RD+K N+LLD N +++DFG+A +GD + G+ Sbjct: 119 ISALDFCHSHS--ICHRDLKPENLLLDERNNIRIADFGMAS-LQVGDS--LLETSCGSPH 173 Query: 245 YAAPEYMSSGHLN-ARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRK 303 YA PE + + ++DV+S GV+L +L G D D R L ++ Sbjct: 174 YACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDD----------DNLRQLLEKVKR 223 Query: 304 VLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTN 363 + + + + S+ + + R T++ + + + + +P Sbjct: 224 GVFHMPHFIPPDC--------QSLLRGMIEVDAARRLTLEHIQKHIWYIGGK-NEPEPEQ 274 Query: 364 PV-KDTKKLGFKTGTTKSSEKRFTQKPFG 391 P+ + + + + + G Sbjct: 275 PIPRKVQIRSLPSLEDIDPDVLDSMHSLG 303 >3FME-A nrPDB Length = 290 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 64/311 (20%), Positives = 122/311 (39%), Gaps = 36/311 (11%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE-GFQGHRE 117 +++ + P +G G +G V K +G ++AVK++ Q + Sbjct: 1 SMEVKADDLEPIMELGRGAYGVVEK---------MRHVPSGQIMAVKRIRATVNSQEQKR 51 Query: 118 WLTEINY-LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 L +++ + + P V G + + E M SL+ + + +P + Sbjct: 52 LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDI 110 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 +A+ K L LHS + VI+RD+K SN+L++A K+ DFG++ Sbjct: 111 LGKIAVSIVKALEHLHSK-LSVIHRDVKPSNVLINALGQVKMCDFGISGYLVD---DVAK 166 Query: 237 TRVMGTYGYAAPEYM----SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVD 292 G Y APE + + + +SD++S G+ ++E+ + D Sbjct: 167 DIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYD-----------S 215 Query: 293 WARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA-LQQ 351 W P+ ++V+ +L E QCL K RPT ++++ Sbjct: 216 WGTPF-QQLKQVVEEPSPQLPADKFSAE---FVDFTSQCLKKNSKERPTYPELMQHPFFT 271 Query: 352 LQDNLGKPSQT 362 L ++ G + Sbjct: 272 LHESKGTDVAS 282 >4ZSG-A nrPDB Length = 347 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 68/333 (20%), Positives = 120/333 (36%), Gaps = 42/333 (12%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTEI 122 + IG G +G V + TG +A+KK+ + + L E+ Sbjct: 7 DEYEIIETIGNGAYGVVSSA---------RRRLTGQQVAIKKIPNAFDVVTNAKRTLREL 57 Query: 123 NYLGQLSHPNLVKLIGY------CLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 L H N++ + E + +V + M+ L + +PL Sbjct: 58 KILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMES-DLHQIIHS----SQPLTLEH 112 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG--PMGDLSY 234 +GL ++HS +VI+RD+K SN+L++ + K+ DFG+AR + Y Sbjct: 113 VRYFLYQLLRGLKYMHS--AQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQY 170 Query: 235 VSTRVMGTYGYAAPEYMSS-GHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDW 293 T + T Y APE M S D++S G + E+L+ ++ + L+ Sbjct: 171 FMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMM 230 Query: 294 ARPYL----------TSKRKVLLIVDNRLDTQY---LPEEAVRMASVAVQCLSFEPKSRP 340 R + + R + P + S+ + L FEP +R Sbjct: 231 VLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARI 290 Query: 341 TMDQVVRA--LQQLQDNLGKPSQTNPVKDTKKL 371 + +R L + D +P P Sbjct: 291 SAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDR 323 >1CM8-A nrPDB Length = 367 Score = 204 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 72/339 (21%), Positives = 125/339 (36%), Gaps = 49/339 (14%) Query: 56 TFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQ 113 T E++ R+ +P +G G +G V TG +A+KKL + + Sbjct: 19 TAWEVRAVYRDLQP---VGSGAYGAVCSA---------VDGRTGAKVAIKKLYRPFQSEL 66 Query: 114 GHREWLTEINYLGQLSHPNLVKLIGYCLEDE------HRLLVYEFMQKGSLENHLFRRGA 167 + E+ L + H N++ L+ DE LV FM L + Sbjct: 67 FAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGKLMKH--- 122 Query: 168 YFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG 227 + L + KGL ++H+ +I+RD+K N+ ++ D K+ DFGLAR Sbjct: 123 --EKLGEDRIQFLVYQMLKGLRYIHA--AGIIHRDLKPGNLAVNEDCELKILDFGLARQA 178 Query: 228 PMGDLSYVSTRVMGTYGYAAPEYMSS-GHLNARSDVYSFGVLLLEILSGKRAL---DHNR 283 T + T Y APE + + D++S G ++ E+++GK DH Sbjct: 179 DSE-----MTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLD 233 Query: 284 PAKEENLVDWARPYLTSKR----------KVLLIVDNRLDTQYLPEEAVRMASVAVQCLS 333 KE V P +R K L ++ + L + ++ + L Sbjct: 234 QLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLV 293 Query: 334 FEPKSRPTMDQVVRA--LQQLQDNLGKPSQTNPVKDTKK 370 + + R T + + + L D +P Sbjct: 294 LDAEQRVTAGEALAHPYFESLHDTEDEPQVQKYDDSFDD 332 >3UC3-A nrPDB Length = 361 Score = 204 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 65/321 (20%), Positives = 120/321 (37%), Gaps = 37/321 (11%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEIN 123 + + IG G FG T ++AVK + + G EI Sbjct: 19 SDRYDFVKDIGSGNFGV---------ARLMRDKLTKELVAVKYI-ERGAAIDENVQREII 68 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 L HPN+V+ L H ++ E+ G L + G + + F Sbjct: 69 NHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNAGRFSEDEARF----FFQQ 124 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDAD--YNAKLSDFGLARDGPMGDLSYVSTRVMG 241 G+++ HS +++ +RD+K N LLD K+ DFG ++ + +G Sbjct: 125 LLSGVSYCHS--MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHS---QPKSTVG 179 Query: 242 TYGYAAPEYMSSGHLNAR-SDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 T Y APE + + + +DV+S GV L +L G + + R Y + Sbjct: 180 TPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDP---------EEPRDYRKT 230 Query: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA---LQQLQDNLG 357 +++L + + D + E + + +P +R ++ ++ L+ L +L Sbjct: 231 IQRILSVKYSIPDDIRISPECCHL---ISRIFVADPATRISIPEIKTHSWFLKNLPADLM 287 Query: 358 KPSQTNPVKDTKKLGFKTGTT 378 S T + ++ T Sbjct: 288 NESNTGSQFQEPEQPMQSLDT 308 >4WB7-A nrPDB Length = 405 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 66/281 (23%), Positives = 118/281 (41%), Gaps = 32/281 (11%) Query: 20 SDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRN------FRPDSVI 73 ++ Y + LS + + E L+ + F + + +N F + Sbjct: 48 AEAYDV-LSDPRKREIFDRYGEEVKEFLA-KAKEDF-LKKWESPAQNTAHLDQFERIKTL 104 Query: 74 GEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW---LTEINYLGQLSH 130 G G FG V + TG A+K L+++ ++ L E L ++ Sbjct: 105 GTGSFGRV---------MLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 155 Query: 131 PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAF 190 P LVKL ++ + +V E++ G + +HL R G + +P F A + Sbjct: 156 PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARF----YAAQIVLTFEY 211 Query: 191 LHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEY 250 LHS + +IYRD+K N+L+D +++DFG A+ + + GT Y APE Sbjct: 212 LHS--LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG-----RTWTLCGTPEYLAPEI 264 Query: 251 MSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 + S N D ++ GVL+ E+ +G ++P + + Sbjct: 265 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI 305 >5EFQ-A nrPDB Length = 347 Score = 203 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 72/325 (22%), Positives = 127/325 (39%), Gaps = 49/325 (15%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG--HREWLTEI 122 F +IGEG +G V+K TG ++A+KK+ + + + EI Sbjct: 11 DKFDIIGIIGEGTYGQVYKA---------RDKDTGEMVALKKVRLDNEKEGFPITAIREI 61 Query: 123 NYLGQLSHPNLVKLIGYCLEDEH----------RLLVYEFMQKGSLENHLFRRGAYFKPL 172 L QL+H +++ + + E LV+E+M L L + Sbjct: 62 KILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLL---ESGLVHF 117 Query: 173 PWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDL 232 + +GL + H ++RDIK SNILL+ KL+DFGLAR + Sbjct: 118 NENHIKSFMRQLMEGLDYCHKK--NFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEES 175 Query: 233 SYVSTRVMGTYGYAAPEYMS-SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 + +V+ T Y PE + DV+S G +L E+ + K N+ + L+ Sbjct: 176 RPYTNKVI-TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELI 234 Query: 292 -------------DWARPYLTSKRKVLLIVDNRLDTQ--YLPEEAVRMASVAVQCLSFEP 336 D + + K +L + ++P A+ + L+ +P Sbjct: 235 SRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYM---LALDP 291 Query: 337 KSRPTMDQVVR--ALQQLQDNLGKP 359 R T +Q ++ L+ ++ + P Sbjct: 292 SKRCTAEQALQCEFLRDVEPSKMPP 316 >4MYG-A nrPDB Length = 372 Score = 203 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 66/323 (20%), Positives = 117/323 (36%), Gaps = 47/323 (14%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTEINYLGQLSH 130 +G G +G V +G +A+KKL++ + + E+ L + H Sbjct: 51 VGSGAYGSVCSA---------IDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMQH 101 Query: 131 PNLVKLIGYCLEDE------HRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 N++ L+ LV FMQ L+ + + Sbjct: 102 ENVIGLLDVFTPASSLRNFYDFYLVMPFMQT-DLQKIM------GMEFSEEKIQYLVYQM 154 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYG 244 KGL ++HS V++RD+K N+ ++ D K+ DFGLAR T + T Sbjct: 155 LKGLKYIHS--AGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE-----MTGYVVTRW 207 Query: 245 YAAPEYMSS-GHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR- 302 Y APE + S H N D++S G ++ E+L+GK + + ++ Sbjct: 208 YRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFV 267 Query: 303 ------------KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA-- 348 + L + TQ P + + A + + L + R T Q + Sbjct: 268 QKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPF 327 Query: 349 LQQLQDNLGKPSQTNPVKDTKKL 371 + +D + P D+ + Sbjct: 328 FEPFRDPEEETEAQQPFDDSLEH 350 >3DB8-A nrPDB Length = 317 Score = 203 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 66/317 (20%), Positives = 125/317 (39%), Gaps = 41/317 (12%) Query: 36 VAAAQKTEGEILS--STPVKSFTFNELKLAT-RNFRPDSVIGEGGFGCVFKGWLDESTLT 92 +A + S P+K + T + + +G+GGF ++ Sbjct: 10 IAKPSAKPSAHVDPKSAPLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYE--------- 60 Query: 93 PTKPGTGLVIAVKKLNQE---GFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLV 149 T T V A K + + + TEI L +P++V G+ +D+ +V Sbjct: 61 ITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPHVVGFHGFFEDDDFVYVV 120 Query: 150 YEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNIL 209 E ++ SL RR A +P + +G+ +LH++ +VI+RD+K N+ Sbjct: 121 LEICRRRSLLELHKRRKAVTEPEARY----FMRQTIQGVQYLHNN--RVIHRDLKLGNLF 174 Query: 210 LDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLL 269 L+ D + K+ DFGLA + GT Y APE + + D++S G +L Sbjct: 175 LNDDMDVKIGDFGLATKIEFD--GERKKDLCGTPNYIAPEVLCKKGHSFEVDIWSLGCIL 232 Query: 270 LEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAV 329 +L GK + L + ++ V ++ +++ Sbjct: 233 YTLLVGKPPFE------TSCLKETYIRIKKNEYSVPRHINPV------------ASALIR 274 Query: 330 QCLSFEPKSRPTMDQVV 346 + L +P RP++ +++ Sbjct: 275 RMLHADPTLRPSVAELL 291 >4QNY-A nrPDB Length = 354 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 71/319 (22%), Positives = 127/319 (39%), Gaps = 41/319 (12%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG---HREWLT 120 + + +IG G +G V + +S ++A+K++N+E F+ + L Sbjct: 19 DDRYLLERIIGAGSYGVVIRARDTKSD--------NRLVAMKRVNKEIFEEVILAKRILR 70 Query: 121 EINYLGQLSHPNLVKLIGYCLEDE-----HRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 EI L + N++ L ++ H +V + M+ L+ L + L Sbjct: 71 EIKLLAHFNDDNIIGLRNILTPEDPENFDHFYIVMDIMET-DLKQVLRS----GQELTEA 125 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 A + L +HS VI+RDI +NIL++ + + K+ DFGLA++ D Sbjct: 126 HIQFFIYQALRALHIIHS--AGVIHRDITPANILVNTNCDLKICDFGLAKE--ENDQGEY 181 Query: 236 STRVMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWA 294 T + Y APE M +A+ DV+ G +L E+L + + + + Sbjct: 182 MTDYVTMRWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDV 241 Query: 295 RPYLTSK----------RKVLLIVDNRLDTQYL---PEEAVRMASVAVQCLSFEPKSRPT 341 + + +K L +R + P + + L F PK R T Sbjct: 242 IGTPSEEDINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRIT 301 Query: 342 MDQVVRA--LQQLQDNLGK 358 + Q +R L+QL D+ Sbjct: 302 VLQAMRHPFLEQLHDDADD 320 >2X4F-A nrPDB Length = 373 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 67/307 (21%), Positives = 120/307 (39%), Gaps = 37/307 (12%) Query: 71 SVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSH 130 ++G G FG V K + TGL +A K + G + E EI+ + QL H Sbjct: 95 EILGGGRFGQVHKC---------EETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDH 145 Query: 131 PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAF 190 NL++L +LV E++ G L + + L L +G+ Sbjct: 146 ANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTIL---FMKQICEGIRH 202 Query: 191 LHSDPVKVIYRDIKASNIL-LDAD-YNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAP 248 +H + +++ D+K NIL ++ D K+ DFGLAR + V+ GT + AP Sbjct: 203 MHQ--MYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVN---FGTPEFLAP 257 Query: 249 EYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIV 308 E ++ ++ +D++S GV+ +LSG + A+ N + R Sbjct: 258 EVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACR------------- 304 Query: 309 DNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQ----QLQDNLGKPSQTNP 364 L+ + + + + L E R + + ++ +L L + N Sbjct: 305 -WDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSDHKLHSRLSAQKKKNR 363 Query: 365 VKDTKKL 371 D + Sbjct: 364 GSDAQDF 370 >4AN9-A nrPDB Length = 301 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 70/287 (24%), Positives = 127/287 (44%), Gaps = 35/287 (12%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWL 119 +L +F S +G G G VFK + +GLV+A K ++ E R + + Sbjct: 5 ELKDDDFEKISELGAGNGGVVFK---------VSHKPSGLVMARKLIHLEIKPAIRNQII 55 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 E+ L + + P +V G D + E M GSL+ L + G +P + Sbjct: 56 RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR----IPEQILGK 111 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 V++ KGL +L K+++RD+K SNIL+++ KL DFG++ + ++ Sbjct: 112 VSIAVIKGLTYLREK-HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL----IDEMANEF 166 Query: 240 MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLT 299 +GT Y +PE + H + +SD++S G+ L+E+ G+ P L+D+ Sbjct: 167 VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYP---RPPMAIFELLDY------ 217 Query: 300 SKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVV 346 ++ +L + ++ +CL P R + Q++ Sbjct: 218 ----IVNEPPPKLPSAVF---SLEFQDFVNKCLIKNPAERADLKQLM 257 >4EWQ-A nrPDB Length = 383 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 76/366 (20%), Positives = 130/366 (35%), Gaps = 55/366 (15%) Query: 38 AAQKTEGEILSSTPVKSFTFNELKLAT----RNFRPDSVIGEGGFGCVFKGWLDESTLTP 93 + + +S +F EL ++ S +G G +G V + Sbjct: 14 GTENLYFQSNASQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAF-------- 65 Query: 94 TKPGTGLVIAVKKLNQ--EGFQGHREWLTEINYLGQLSHPNLVKLIGYCL------EDEH 145 TGL +AVKKL++ + + E+ L + H N++ L+ E Sbjct: 66 -DTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFND 124 Query: 146 RLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKA 205 LV M L N + + L + +GL ++HS +I+RD+K Sbjct: 125 VYLVTHLM-GADLNNIVKCQK-----LTDDHVQFLIYQILRGLKYIHS--ADIIHRDLKP 176 Query: 206 SNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSS-GHLNARSDVYS 264 SN+ ++ D K+ DFGLAR YV+ T Y APE M + H N D++S Sbjct: 177 SNLAVNEDCELKILDFGLARHTDDEMTGYVA-----TRWYRAPEIMLNWMHYNQTVDIWS 231 Query: 265 FGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEA--- 321 G ++ E+L+G+ + L+ R T ++L + + Y+ Sbjct: 232 VGCIMAELLTGRTLFPGTDHIDQLKLI--LRLVGTPGAELLKKISSESARNYIQSLTQMP 289 Query: 322 ------------VRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVKDTK 369 + + L + R T Q + PV D Sbjct: 290 KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAH---AYFAQYHDPDDEPVADPY 346 Query: 370 KLGFKT 375 F++ Sbjct: 347 DQSFES 352 >2XNP-A nrPDB Length = 279 Score = 202 bits (513), Expect = 3e-52, Method: Composition-based stats. Identities = 58/291 (19%), Positives = 118/291 (40%), Gaps = 35/291 (12%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE--WLTE 121 ++ IG G +G K + G ++ K+L+ + ++E Sbjct: 5 AEDYEVLYTIGTGSYGRCQK---------IRRKSDGKILVWKELDYGSMTEAEKQMLVSE 55 Query: 122 INYLGQLSHPNLVKLIGYCLEDEH--RLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 +N L +L HPN+V+ ++ + +V E+ + G L + + + + L + Sbjct: 56 VNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLR 115 Query: 180 VALDAAKGLAFLHSDPVK---VIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 V L H V++RD+K +N+ LD N KL DFGLAR + + + Sbjct: 116 VMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLAR--ILNHDTSFA 173 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 +GT Y +PE M+ N +SD++S G LL E+ + Sbjct: 174 KTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTA--------------- 218 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 S++++ + + + + + + L+ + RP++++++ Sbjct: 219 --FSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILE 267 >3ALO-A nrPDB Length = 327 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 67/307 (21%), Positives = 119/307 (38%), Gaps = 31/307 (10%) Query: 48 SSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL 107 SS +K + + IG G +G V K +G ++AVK++ Sbjct: 5 SSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNK---------MVHKPSGQIMAVKRI 55 Query: 108 NQE-GFQGHREWLTEINY-LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR 165 + ++ L +++ + P +V+ G + + E M + + + Sbjct: 56 RSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVY 115 Query: 166 GAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR 225 +P + + L K L L + +K+I+RDIK SNILLD N KL DFG++ Sbjct: 116 SVLDDVIPEEILGKITLATVKALNHL-KENLKIIHRDIKPSNILLDRSGNIKLCDFGISG 174 Query: 226 DGPMGDLSYVSTRVMGTYGYAAPEYM----SSGHLNARSDVYSFGVLLLEILSGKRALDH 281 S TR G Y APE + S + RSDV+S G+ L E+ +G+ Sbjct: 175 QLVD---SIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPK 231 Query: 282 NRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPT 341 ++ +V+ +L E + + CL+ + RP Sbjct: 232 WNSVFDQLT------------QVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPK 279 Query: 342 MDQVVRA 348 ++++ Sbjct: 280 YKELLKH 286 >5Z33-A nrPDB Length = 425 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 75/354 (21%), Positives = 128/354 (36%), Gaps = 45/354 (12%) Query: 56 TFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQ 113 FN+ + + +G+G +G V ++ T +A+KK+ Sbjct: 22 VFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQ---------TSEGVAIKKVTNVFSKKI 72 Query: 114 GHREWLTEINYLGQLS-HPNLVKLIGYCL---EDEHRLLVYEFMQKGSLENHLFRRGAYF 169 + L EI L H N+ L + ++ + +YE + + L + Sbjct: 73 LAKRALREIKLLQHFRGHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRS----G 128 Query: 170 KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR--DG 227 +PL + GL ++HS V++RD+K N+L++AD K+ DFGLAR Sbjct: 129 QPLTDAHFQSFIYQILCGLKYIHS--ANVLHRDLKPGNLLVNADCELKICDFGLARGFSV 186 Query: 228 PMGDLSYVSTRVMGTYGYAAPEYMSS-GHLNARSDVYSFGVLLLEILSGKRALDHNRPA- 285 + + T + T Y APE M S DV+S G +L E+L G R R Sbjct: 187 DPEENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELL-GGRPFFKGRDYV 245 Query: 286 -------------KEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCL 332 EE L P + L + + P + + L Sbjct: 246 DQLNQILHILGTPNEETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRML 305 Query: 333 SFEPKSRPTMDQVVRA--LQQLQDNLGKPSQTNPVKDTKKLGFKTGTTKSSEKR 384 +F+P SR +++Q + L D +P F+ ++ Sbjct: 306 AFDPSSRISVEQALEHPYLHIWHDASDEPDCPTTFN----FDFEVVEDVGEMRK 355 >3UDB-A nrPDB Length = 317 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 62/321 (19%), Positives = 115/321 (35%), Gaps = 37/321 (11%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEIN 123 + + IG G FG ++AVK + + G + EI Sbjct: 18 SDRYELVKDIGAGNFGV---------ARLMRDKQANELVAVKYI-ERGEKIDENVKREII 67 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 L HPN+V+ L H +V E+ G L + G + + F Sbjct: 68 NHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARF----FFQQ 123 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDAD--YNAKLSDFGLARDGPMGDLSYVSTRVMG 241 G+++ H+ ++V +RD+K N LLD K++DFG ++ + +G Sbjct: 124 LISGVSYAHA--MQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHS---QPKSAVG 178 Query: 242 TYGYAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 T Y APE + + + DV+S GV L +L G + P + +N L Sbjct: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFED--PEEPKNFRKTIHRILNV 236 Query: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA---LQQLQDNLG 357 + + V + ++ + + +P R ++ ++ L+ L +L Sbjct: 237 QYAIPDYVHISPECRH----------LISRIFVADPAKRISIPEIRNHEWFLKNLPADLM 286 Query: 358 KPSQTNPVKDTKKLGFKTGTT 378 + D ++ Sbjct: 287 NDNTMTTQFDESDQPGQSIEE 307 >3ZUT-A nrPDB Length = 362 Score = 201 bits (512), Expect = 4e-52, Method: Composition-based stats. Identities = 61/321 (19%), Positives = 114/321 (35%), Gaps = 37/321 (11%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEIN 123 + + IG G FG + ++AVK + + G + EI Sbjct: 18 SDRYELVKDIGSGNFGV---------ARLMRDKQSNELVAVKYI-ERGEKIDENVKREII 67 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 L HPN+V+ L H +V E+ G L + G + + F Sbjct: 68 NHRSLRHPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARF----FFQQ 123 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDAD--YNAKLSDFGLARDGPMGDLSYVSTRVMG 241 G+++ H+ ++V +RD+K N LLD K+ FG ++ + +G Sbjct: 124 LISGVSYCHA--MQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHS---QPKSTVG 178 Query: 242 TYGYAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 T Y APE + + + DV+S GV L +L G + P + +N L Sbjct: 179 TPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFED--PEEPKNFRKTIHRILNV 236 Query: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA---LQQLQDNLG 357 + + V + ++ + + +P R ++ ++ L+ L +L Sbjct: 237 QYAIPDYVHISPECRH----------LISRIFVADPAKRISIPEIRNHEWFLKNLPADLM 286 Query: 358 KPSQTNPVKDTKKLGFKTGTT 378 + D ++ Sbjct: 287 NDNTMTTQFDESDQPGQSIEE 307 >5FET-A nrPDB Length = 847 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 66/314 (21%), Positives = 117/314 (37%), Gaps = 42/314 (13%) Query: 2 GSCFSSRVKADIFHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILS--------STPV- 52 G + K D F G+ + LY +++S ++ A E + P+ Sbjct: 463 GKRLRTLGKNDYF--GERALLYD----EPRTASIISKATSVECWFVDKSVFLQIIQGPML 516 Query: 53 ----KSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN 108 + + K+ + +IG G FG V T + A+K ++ Sbjct: 517 THLEERIKMQDTKVEMHELETERIIGRGTFGTV---------KLVHHKPTQIRYALKCVS 567 Query: 109 QEGFQG---HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR 165 + E + HP +++L+ + + E + G L + + + Sbjct: 568 KRSIISLNQQNNIKLEREITAENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIRKL 627 Query: 166 GAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR 225 G KP F ++ L + +LH ++YRD+K NILLD KL DFG A+ Sbjct: 628 GLLSKPQAQFYLGSIIL----AIEYLHER--NIVYRDLKPENILLDKQGYVKLIDFGCAK 681 Query: 226 DGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPA 285 + ++GT Y APE + D+++ GV L E + G +++ Sbjct: 682 KIQGRAYT-----LVGTPHYMAPEVILGKGYGCTVDIWALGVCLYEFICGPLPFGNDQED 736 Query: 286 KEENLVDWARPYLT 299 + E D LT Sbjct: 737 QLEIFRDILTGQLT 750 >2I0E-A nrPDB Length = 353 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 64/262 (24%), Positives = 119/262 (45%), Gaps = 22/262 (8%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW-- 118 ++ +F V+G+G FG V + + GT + AVK L ++ + Sbjct: 16 RMKLTDFNFLMVLGKGSFGKV---------MLSERKGTDELYAVKILKKDVVIQDDDVEC 66 Query: 119 -LTEINYLGQLSHP-NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 + E L P L +L + V E++ G L H+ + G + +P F Sbjct: 67 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFY 126 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 +A+ GL FL S +IYRD+K N++LD++ + K++DFG+ ++ ++ + Sbjct: 127 AAEIAI----GLFFLQSK--GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT--T 178 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK-EENLVDWAR 295 GT Y APE ++ D ++FGVLL E+L+G+ + + +++++ Sbjct: 179 KTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNV 238 Query: 296 PYLTSKRKVLLIVDNRLDTQYL 317 Y S K + + L T++ Sbjct: 239 AYPKSMSKEAVAICKGLMTKHP 260 >2BRG-A nrPDB Length = 297 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 70/314 (22%), Positives = 123/314 (39%), Gaps = 34/314 (10%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN-QEGFQGHREWLTEIN 123 ++ +GEG +G V T +AVK ++ + EI Sbjct: 7 EDWDLVQTLGEGAYGEVQLA---------VNRVTEEAVAVKIVDMKRAVDCPENIKKEIC 57 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 L+H N+VK G+ E + L E+ G L + + +P Sbjct: 58 INKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRI----EPDIGMPEPDAQRFFHQ 113 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 G+ +LH + + +RDIK N+LLD N K+SDFGLA + + ++ GT Sbjct: 114 LMAGVVYLH--GIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTL 171 Query: 244 GYAAPEYMSSGHLNAR-SDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 Y APE + +A DV+S G++L +L+G+ D + +E DW ++ Sbjct: 172 PYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQE-YSDWK------EK 224 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQT 362 K L ++D+ L ++ + L P +R T+ + + + + K Sbjct: 225 KTYLNPWKKIDSAPL--------ALLHKILVENPSARITIPDIKK--DRWYNKPLKKGAK 274 Query: 363 NPVKDTKKLGFKTG 376 P + + Sbjct: 275 RPRVTSGGVSESPS 288 >3PFQ-A nrPDB Length = 674 Score = 201 bits (511), Expect = 5e-52, Method: Composition-based stats. Identities = 64/262 (24%), Positives = 119/262 (45%), Gaps = 22/262 (8%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW-- 118 ++ +F V+G+G FG V + + GT + AVK L ++ + Sbjct: 337 RMKLTDFNFLMVLGKGSFGKV---------MLSERKGTDELYAVKILKKDVVIQDDDVEC 387 Query: 119 -LTEINYLGQLSHP-NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 + E L P L +L + V E++ G L H+ + G + +P F Sbjct: 388 TMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFY 447 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 +A+ GL FL S +IYRD+K N++LD++ + K++DFG+ ++ ++ + Sbjct: 448 AAEIAI----GLFFLQSK--GIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVT--T 499 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK-EENLVDWAR 295 GT Y APE ++ D ++FGVLL E+L+G+ + + +++++ Sbjct: 500 KTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNV 559 Query: 296 PYLTSKRKVLLIVDNRLDTQYL 317 Y S K + + L T++ Sbjct: 560 AYPKSMSKEAVAICKGLMTKHP 581 >4NST-A nrPDB Length = 351 Score = 201 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 69/310 (22%), Positives = 116/310 (37%), Gaps = 43/310 (13%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG--HREWLTEI 122 F +IGEG +G V+K TG ++A+KK+ + + + EI Sbjct: 13 DKFDIIGIIGEGTYGQVYKA---------KDKDTGELVALKKVRLDNEKEGFPITAIREI 63 Query: 123 NYLGQLSHPNLVKLIGYCLEDEH----------RLLVYEFMQKGSLENHLFRRGAYFKPL 172 L QL H ++V + + + LV+E+M L L + Sbjct: 64 KILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLL---ESGLVHF 119 Query: 173 PWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDL 232 + +GL + H ++RDIK SNILL+ KL+DFGLAR + Sbjct: 120 SEDHIKSFMKQLMEGLEYCHKK--NFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEES 177 Query: 233 SYVSTRVMGTYGYAAPEYMS-SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 + +V+ T Y PE + DV+S G +L E+ + K N + L+ Sbjct: 178 RPYTNKVI-TLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELI 236 Query: 292 -------------DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKS 338 D + + K RL ++ + L+ +P Sbjct: 237 SRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEF-SFIPSAALDLLDHMLTLDPSK 295 Query: 339 RPTMDQVVRA 348 R T +Q +++ Sbjct: 296 RCTAEQTLQS 305 >4BGQ-A nrPDB Length = 304 Score = 201 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 68/315 (21%), Positives = 113/315 (35%), Gaps = 41/315 (13%) Query: 54 SFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN--QEG 111 S + F V+GEG +G V K E T ++A+KK +E Sbjct: 1 SMKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKE---------THEIVAIKKFKDSEEN 51 Query: 112 FQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKP 171 + L E+ L L N+V+L LV+E+++K L L P Sbjct: 52 EEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNML-ELLEEMPNGVPP 110 Query: 172 LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGD 231 + K + + H + +++RDIK N+L+ + KL DFG AR+ G+ Sbjct: 111 EK---VKSYIYQLIKAIHWCHKND--IVHRDIKPENLLISHNDVLKLCDFGFARNLSEGN 165 Query: 232 LSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 + V T Y +PE + D++S G +L E+ G+ + + Sbjct: 166 NANYDEEVA-TRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTI 224 Query: 292 DWARPYLTSKRKVLLIVDNR--------------LDTQYLPEEAVRMASVAVQCLSFEPK 337 L S++ L + R L+ +YL + + L +P Sbjct: 225 QKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPA 284 Query: 338 SR---------PTMD 343 R PT Sbjct: 285 DRYLTEQCLNHPTFQ 299 >1UA2-A nrPDB Length = 346 Score = 201 bits (510), Expect = 6e-52, Method: Composition-based stats. Identities = 68/306 (22%), Positives = 117/306 (38%), Gaps = 33/306 (10%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG---- 114 ++K + + +GEG F V+K T ++A+KK+ Sbjct: 4 DVKSRAKRYEKLDFLGEGQFATVYKA---------RDKNTNQIVAIKKIKLGHRSEAKDG 54 Query: 115 -HREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLP 173 +R L EI L +LSHPN++ L+ + LV++FM+ LE + P Sbjct: 55 INRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMET-DLEVIIKDNSLVLTP-- 111 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 L +GL +LH +++RD+K +N+LLD + KL+DFGLA+ + + Sbjct: 112 -SHIKAYMLMTLQGLEYLHQHW--ILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA 168 Query: 234 YVSTRVMGTYGYAAPEYMSSGH-LNARSDVYSFGVLLLEILSGKR--ALDHNRPAKEENL 290 Y T + T Y APE + D+++ G +L E+L D + Sbjct: 169 Y--THQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIF 226 Query: 291 VDWARPYLTSKRKVLLIVDNRLDTQYL--------PEEAVRMASVAVQCLSFEPKSRPTM 342 P + + D + + + F P +R T Sbjct: 227 ETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITA 286 Query: 343 DQVVRA 348 Q ++ Sbjct: 287 TQALKM 292 >5N23-A nrPDB Length = 352 Score = 200 bits (509), Expect = 8e-52, Method: Composition-based stats. Identities = 59/230 (25%), Positives = 98/230 (42%), Gaps = 22/230 (9%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW---LTE 121 F +G G FG V + TG A+K L+++ ++ L E Sbjct: 42 DQFERIRTLGTGSFGRV---------MLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNE 92 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 ++ P LVKL ++ + +V E+ G + +HL R G + +P F A Sbjct: 93 KRIQQAVNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARF----YA 148 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 +LHS + +IYRD+K N+L+D K++DFG A+ + G Sbjct: 149 AQIVLTFEYLHS--LDLIYRDLKPENLLIDQQGYIKVADFGFAKRVK----GRTPWTLCG 202 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 T Y APE + S N D ++ GVL+ E+ +G ++P + + Sbjct: 203 TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI 252 >4I6B-A nrPDB Length = 308 Score = 200 bits (509), Expect = 8e-52, Method: Composition-based stats. Identities = 55/287 (19%), Positives = 105/287 (36%), Gaps = 38/287 (13%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG---HREWLTE 121 + + +G+GGF ++ T V A K + + E Sbjct: 28 KRYSRGKTLGKGGFAKCYE---------MTDLTNNKVYAAKIIPHSRVSKPHQREKIDKE 78 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 I L H ++V+ Y + E+ ++ E+ + S+ + L R +P Sbjct: 79 IELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPE----VRYYL 134 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 GL +LH +++RD+K N ++ K+ DFGLA + L + + G Sbjct: 135 RQIVSGLKYLHEQE--ILHRDLKLGNFFINESMELKVGDFGLA--ARLEPLEHRRRTICG 190 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK 301 T Y +PE ++ A SD+++ G ++ +L G+ + + + AR Sbjct: 191 TPNYLSPEVLNKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARY----- 245 Query: 302 RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + LS P+ RP++D ++R Sbjct: 246 -------------TMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRH 279 >3OHT-A nrPDB Length = 389 Score = 200 bits (508), Expect = 9e-52, Method: Composition-based stats. Identities = 76/380 (20%), Positives = 133/380 (35%), Gaps = 52/380 (13%) Query: 23 YGLSLSSRKSSSTVAAAQKTEGEI-LSSTPVKSFTFNELKLAT----RNFRPDSVIGEGG 77 Y +S+S A +S +F EL ++ S +G G Sbjct: 4 YHHHHHHLESTSLYKKAGSAAAPFTMSHKERPTFYRQELNKTIWEVPERYQTLSPVGSGA 63 Query: 78 FGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTEINYLGQLSHPNLVK 135 +G V + +GL IAVKKL++ + + E+ L + H N++ Sbjct: 64 YGSVCSSY---------DVKSGLKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIG 114 Query: 136 LIGYCL------EDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 L+ E LV M L N + + L + +GL Sbjct: 115 LLDVFTPATSLEEFNDVYLVTHLM-GADLNNIVKCQK-----LTDDHVQFLIYQILRGLK 168 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPE 249 ++HS +I+RD+K SN+ ++ D K+ DFGLAR YV+ T Y APE Sbjct: 169 YIHS--ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVA-----TRWYRAPE 221 Query: 250 YMSS-GHLNARSDVYSFGVLLLEILSGKRALDH----NRPAKEENLVDWARPYLTSKRKV 304 M + H N D++S G ++ E+L+G+ N+ + L + S+ Sbjct: 222 IMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMPS 281 Query: 305 LLIVDNRLDTQYLPE---------EAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 + +P+ + + L + R T + + + Sbjct: 282 HEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHP---YFS 338 Query: 356 LGKPSQTNPVKDTKKLGFKT 375 P + F++ Sbjct: 339 QYHDPDDEPESEPYDQSFES 358 >4AU8-A nrPDB Length = 296 Score = 200 bits (508), Expect = 9e-52, Method: Composition-based stats. Identities = 66/302 (21%), Positives = 116/302 (38%), Gaps = 32/302 (10%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG--HREWL 119 + ++ + IGEG +G VFK E T ++A+K++ + L Sbjct: 3 MGSQKYEKLEKIGEGTYGTVFKAKNRE---------THEIVALKRVRLDDDDEGVPSSAL 53 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 EI L +L H N+V+L D+ LV+EF L+ + P + + Sbjct: 54 REICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCD-QDLKKYFDSCNGDLDPE---IVKS 109 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 KGL F HS V++RD+K N+L++ + KL+DFGLAR + Y + V Sbjct: 110 FLFQLLKGLGFCHSR--NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVV 167 Query: 240 MGTYGYAAPEYMSSGH-LNARSDVYSFGVLLLEILSGKRALDHNRPAKEEN---LVDWAR 295 T Y P+ + + D++S G + E+ + R L ++ Sbjct: 168 --TLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGT 225 Query: 296 PYLTSKRKVLLIVDNRLDTQYL---------PEEAVRMASVAVQCLSFEPKSRPTMDQVV 346 P + + D + Y P+ + L P R + ++ + Sbjct: 226 PTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEAL 285 Query: 347 RA 348 + Sbjct: 286 QH 287 >5X3F-B nrPDB Length = 393 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 63/276 (22%), Positives = 118/276 (42%), Gaps = 30/276 (10%) Query: 25 LSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRN------FRPDSVIGEGGF 78 L S+ ++ A + + + + + F + + ++N F +G G F Sbjct: 39 LDDPSQSANLLAEAKKLNDVQAFLAKAKEDF-LKKWETPSQNTAQLDQFDRIKTLGTGSF 97 Query: 79 GCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW---LTEINYLGQLSHPNLVK 135 G V + +G A+K L+++ ++ L E L ++ P LVK Sbjct: 98 GRV---------MLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVK 148 Query: 136 LIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDP 195 L ++ + +V E++ G + +HL R G + +P F A +LHS Sbjct: 149 LEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARF----YAAQIVLTFEYLHS-- 202 Query: 196 VKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGH 255 + +IYRD+K N+L+D +++DFG A+ + + GT Y APE + S Sbjct: 203 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG-----RTWTLCGTPEYLAPEIILSKG 257 Query: 256 LNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 N D ++ GVL+ E+ +G ++P + + Sbjct: 258 YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKI 293 >4AW2-A nrPDB Length = 437 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 71/318 (22%), Positives = 115/318 (36%), Gaps = 36/318 (11%) Query: 2 GSCFSSRVKADIFHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILS-STPVKSFTFNEL 60 G CFS DI LY +S K E L + P S ++ Sbjct: 22 GQCFSVETLLDILI-----CLYDECNNSPLRRE------KNILEYLEWAKPFTS-KVKQM 69 Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE--- 117 +L +F VIG G FG V V A+K LN+ E Sbjct: 70 RLHREDFEILKVIGRGAFGEV---------AVVKLKNADKVFAMKILNKWEMLKRAETAC 120 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 + E + L + L +D + LV ++ G L L + + LP + Sbjct: 121 FREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSK---FEDRLPEEMA 177 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 + + +H + ++RDIK NIL+D + + +L+DFG M D + S+ Sbjct: 178 RFYLAEMVIAIDSVHQ--LHYVHRDIKPDNILMDMNGHIRLADFGSCLKL-MEDGTVQSS 234 Query: 238 RVMGTYGYAAPEYMS-----SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVD 292 +GT Y +PE + G D +S GV + E+L G+ + + Sbjct: 235 VAVGTPDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIM 294 Query: 293 WARPYLTSKRKVLLIVDN 310 + +V + +N Sbjct: 295 NHKERFQFPTQVTDVSEN 312 >5JZN-A nrPDB Length = 280 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 60/290 (20%), Positives = 109/290 (37%), Gaps = 37/290 (12%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL-TEI 122 T ++ IG+G F V + + T A+K + + +G + E+ Sbjct: 18 TERYKVGRTIGDGNFAVVKEC---------VERSTAREYALKIIKKSKCRGKEHMIQNEV 68 Query: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 + L ++ HPN+V LI LV E ++ G L + + Y + + Sbjct: 69 SILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTER----DASGMLY 124 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILL----DADYNAKLSDFGLARDGPMGDLSYVSTR 238 + A + +LHS + +++RDIK N+L+ D + KL DFGLA + Sbjct: 125 NLASAIKYLHS--LNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYT----- 177 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 V GT Y APE ++ + D+++ GV+ +L G + +E + Sbjct: 178 VCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQV 237 Query: 299 TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + Y + + L + R + QV+ Sbjct: 238 D------------FPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEH 275 >4NIF-A nrPDB Length = 333 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 63/292 (21%), Positives = 113/292 (38%), Gaps = 37/292 (12%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTE 121 + + + IG G + + T + AVK +++ R+ E Sbjct: 5 VFSDGYVVKETIGVGSYSECKRC---------VHKATNMEYAVKVIDK----SKRDPSEE 51 Query: 122 INYLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 I L + HPN++ L + +H LV E M+ G L + + R+ + + F V Sbjct: 52 IEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASF----V 107 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNIL-LDADYN---AKLSDFGLARDGPMGDLSYVS 236 K + +LHS V++RD+K SNIL +D N ++ DFG A+ + ++ Sbjct: 108 LHTIGKTVEYLHSQ--GVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMT 165 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 T + APE + + D++S G+LL +L+G + E + Sbjct: 166 P--CYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEI------ 217 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 LT + + + + L +P R T QV++ Sbjct: 218 -LTRIGSGKFTLSGGNWNTV----SETAKDLVSKMLHVDPHQRLTAKQVLQH 264 >2Y7J-A nrPDB Length = 365 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 69/303 (22%), Positives = 125/303 (41%), Gaps = 47/303 (15%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVK-------KLNQEGFQ 113 K + + P VIG G V + TG AVK +L+ E + Sbjct: 90 KEFYQKYDPKDVIGRGVSSVVRRC---------VHRATGHEFAVKIMEVTAERLSPEQLE 140 Query: 114 GHREW-LTEINYLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKP 171 RE E + L Q+ HP+++ LI LV++ M+KG L ++L + A + Sbjct: 141 EVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEK 200 Query: 172 LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGD 231 + + ++FLH++ +++RD+K NILLD + +LSDFG + G+ Sbjct: 201 ETRS----IMRSLLEAVSFLHAN--NIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGE 254 Query: 232 LSYVSTRVMGTYGYAAPEYMSSG------HLNARSDVYSFGVLLLEILSGKRALDHNRPA 285 + GT GY APE + D+++ GV+L +L+G Sbjct: 255 ---KLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPF------ 305 Query: 286 KEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQV 345 W R + R ++ ++ + + + + + L +P++R T +Q Sbjct: 306 -------WHRRQILMLRMIMEGQYQFSSPEW-DDRSSTVKDLISRLLQVDPEARLTAEQA 357 Query: 346 VRA 348 ++ Sbjct: 358 LQH 360 >4FR4-A nrPDB Length = 384 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 66/287 (22%), Positives = 105/287 (36%), Gaps = 41/287 (14%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH---REWLTE 121 +F IG+G FG V K T + A+K +N++ R E Sbjct: 15 DHFEILRAIGKGSFGKVC---------IVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKE 65 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 + + L HP LV L ++E +V + + G L HL + + + Sbjct: 66 LQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEE----TVKLFI 121 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 + L +L ++I+RD+K NILLD + ++DF +A P T + G Sbjct: 122 CELVMALDYL--QNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPR---ETQITTMAG 176 Query: 242 TYGYAAPEYMSSGH---LNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 T Y APE SS + D +S GV E+L G+R + +V + Sbjct: 177 TKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTV 236 Query: 299 TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQV 345 Y + M S+ + L P R Q+ Sbjct: 237 V---------------TYPSAWSQEMVSLLKKLLEPNPDQR--FSQL 266 >5DYK-A nrPDB Length = 853 Score = 199 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 62/311 (19%), Positives = 115/311 (36%), Gaps = 42/311 (13%) Query: 5 FSSRVKADIFHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILS--------STPV---- 52 + K D F G+ + LY +++S ++ E + P+ Sbjct: 472 LRTLGKNDYF--GERALLYD----EPRTASVISKVNNVECWFVDKSVFLQIIQGPMLAHL 525 Query: 53 -KSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEG 111 + + K+ + +IG G FG V T + A+K +++ Sbjct: 526 EERIKMQDTKVEMDELETERIIGRGTFGTV---------KLVHHKPTKIRYALKCVSKRS 576 Query: 112 F---QGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAY 168 E + HP +++L+ + ++ + E + G L + + + G Sbjct: 577 IINLNQQNNIKLEREITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLL 636 Query: 169 FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGP 228 K F ++ L + +LH ++YRD+K NILLD KL DFG A+ Sbjct: 637 SKSQAQFYLGSIIL----AIEYLHER--NIVYRDLKPENILLDKQGYVKLIDFGCAKKVQ 690 Query: 229 MGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEE 288 + ++GT Y APE + D+++ G+ L E + G ++ + E Sbjct: 691 GRAYT-----LVGTPHYMAPEVILGKGYGCTVDIWALGICLYEFICGPLPFGNDEEDQLE 745 Query: 289 NLVDWARPYLT 299 D LT Sbjct: 746 IFRDILTGQLT 756 >6E2O-A nrPDB Length = 295 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 59/290 (20%), Positives = 114/290 (39%), Gaps = 39/290 (13%) Query: 66 NFRPDS-----VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 ++ D V+G+G +G V+ G + IA+K++ + + + Sbjct: 18 DYEYDENGDRVVLGKGTYGIVYAG---------RDLSNQVRIAIKEIPERDSRYSQPLHE 68 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 EI L H N+V+ +G E+ + E + GSL L + K Sbjct: 69 EIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKD-NEQTIGFY 127 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDA-DYNAKLSDFGLARDGPMGDLSYVSTRV 239 +GL +LH + +++RDIK N+L++ K+SDFG ++ + ++ + Sbjct: 128 TKQILEGLKYLHDNQ--IVHRDIKGDNVLINTYSGVLKISDFGTSK--RLAGINPCTETF 183 Query: 240 MGTYGYAAPEYMSSGH--LNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY 297 GT Y APE + G +D++S G ++E+ +GK Sbjct: 184 TGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYE---------------- 227 Query: 298 LTSKRKVLLIVDNRLDTQYLPEE-AVRMASVAVQCLSFEPKSRPTMDQVV 346 L + + V +PE + + ++C +P R + ++ Sbjct: 228 LGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLL 277 >3Q4U-A nrPDB Length = 301 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 68/320 (21%), Positives = 125/320 (39%), Gaps = 49/320 (15%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 + R+ +G+G +G V++G G +AVK + + + W Sbjct: 4 RTVARDITLLECVGKGRYGEVWRGSW-----------QGENVAVKIFSS---RDEKSWFR 49 Query: 121 EINYLG--QLSHPNLVKLIGYCLEDEH----RLLVYEFMQKGSLENHLFRRGAYFKPLPW 174 E L H N++ I + H L+ + + GSL ++L L Sbjct: 50 ETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYL-----QLTTLDT 104 Query: 175 FLRVNVALDAAKGLAFLH------SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGP 228 + + L A GLA LH + +RD+K+ NIL+ + ++D GLA Sbjct: 105 VSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHS 164 Query: 229 M--GDLSYVSTRVMGTYGYAAPEYMSSG------HLNARSDVYSFGVLLLE----ILSGK 276 L + +GT Y APE + R D+++FG++L E ++S Sbjct: 165 QSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNG 224 Query: 277 RALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNR--LDTQYLPEEAV-RMASVAVQCLS 333 D+ P + D P RKV+ + R + ++ + + +A + +C Sbjct: 225 IVEDYKPPFYDVVPND---PSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWY 281 Query: 334 FEPKSRPTMDQVVRALQQLQ 353 P +R T ++ + L ++ Sbjct: 282 QNPSARLTALRIKKTLTKID 301 >3ORZ-A nrPDB Length = 316 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 51/278 (18%), Positives = 106/278 (38%), Gaps = 36/278 (12%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW---LTE 121 +F+ ++GEG F V + T A+K L + + E Sbjct: 37 EDFKFGKILGEGSFSTVVLA---------RELATSREYAIKILEKRHIIKENKVPYVTRE 87 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 + + +L HP VKL +DE + + G L ++ + G++ + F Sbjct: 88 RDVMSRLDHPFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTA--- 144 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 + L +LH +I+RD+K NILL+ D + +++DFG A+ + +G Sbjct: 145 -EIVSALEYLHGK--GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVG 201 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK 301 T Y +PE ++ SD+++ G ++ ++++G Sbjct: 202 TAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPF------------------RAGN 243 Query: 302 RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSR 339 ++ +L+ + + + + + L + R Sbjct: 244 EYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKR 281 >1PHK-A nrPDB Length = 298 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 63/301 (20%), Positives = 119/301 (39%), Gaps = 48/301 (15%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN---------QEGFQG 114 N+ P ++G G V + T AVK ++ +E + Sbjct: 16 YENYEPKEILGRGVSSVVRRC---------IHKPTCKEYAVKIIDVTGGGSFSAEEVQEL 66 Query: 115 HREWLTEINYLGQLS-HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLP 173 L E++ L ++S HPN+++L + LV++ M+KG L ++L + + Sbjct: 67 REATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKET 126 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 + + + LH + +++RD+K NILLD D N KL+DFG + G+ Sbjct: 127 R----KIMRALLEVICALH--KLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGE-- 178 Query: 234 YVSTRVMGTYGYAAPEYMSSG------HLNARSDVYSFGVLLLEILSGKRALDHNRPAKE 287 V GT Y APE + D++S GV++ +L+G Sbjct: 179 -KLREVCGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPF-------- 229 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 W R + R ++ ++ + + + + + L +P+ R T ++ + Sbjct: 230 -----WHRKQMLMLRMIMSGNYQFGSPEW-DDYSDTVKDLVSRFLVVQPQKRYTAEEALA 283 Query: 348 A 348 Sbjct: 284 H 284 >3GC9-A nrPDB Length = 370 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 70/366 (19%), Positives = 125/366 (34%), Gaps = 51/366 (13%) Query: 49 STPVKSFTFNELKLAT----RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAV 104 S P F EL + + +G G +G V + +AV Sbjct: 8 SGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLR---------QKVAV 58 Query: 105 KKLNQ--EGFQGHREWLTEINYLGQLSHPNLVKLIGYCL------EDEHRLLVYEFMQKG 156 KKL++ + R E+ L L H N++ L+ + LV M Sbjct: 59 KKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GA 117 Query: 157 SLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA 216 L N + + + + + + +GL ++HS +I+RD+K SN+ ++ D Sbjct: 118 DLNNIVKSQALSDEHVQF-----LVYQLLRGLKYIHS--AGIIHRDLKPSNVAVNEDSEL 170 Query: 217 KLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSS-GHLNARSDVYSFGVLLLEILSG 275 ++ DFGLAR YV+ T Y APE M + H N D++S G ++ E+L G Sbjct: 171 RILDFGLARQADEEMTGYVA-----TRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQG 225 Query: 276 KRALDHNRPAKEENLVDWA--RPYLTSKRKVLLIVDNRLDTQYLPEEAVRM--------- 324 K + + + P K+ P + Sbjct: 226 KALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANP 285 Query: 325 --ASVAVQCLSFEPKSRPTMDQVVRA--LQQLQDNLGKPSQTNPVKDTKKLGFKTGTTKS 380 + + L + R + + + Q D +P + P ++ + +T Sbjct: 286 LAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEP-EAEPYDESVEAKERTLEEWK 344 Query: 381 SEKRFT 386 Sbjct: 345 ELTYQE 350 >3GUB-A nrPDB Length = 295 Score = 198 bits (503), Expect = 4e-51, Method: Composition-based stats. Identities = 61/298 (20%), Positives = 114/298 (38%), Gaps = 42/298 (14%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR---- 116 + + +G G F V K + TGL A K + + + R Sbjct: 7 ENVDDYYDTGEELGSGQFAVVKKC---------REKSTGLQYAAKFIKKRRTKSSRRGVS 57 Query: 117 --EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPW 174 + E++ L ++ HPN++ L +L+ E + G L + L + + + Sbjct: 58 REDIEREVSILKEIQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKESLTEEEAT 117 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY----NAKLSDFGLARDGPMG 230 G+ +LHS +++ + D+K NI+L K+ DFGLA G Sbjct: 118 ----EFLKQILNGVYYLHS--LQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFG 171 Query: 231 DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENL 290 + + GT + APE ++ L +D++S GV+ +LSG + K+E L Sbjct: 172 NE---FKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGD--TKQETL 226 Query: 291 VDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + V+ + +Y + + L +PK R T+ ++ Sbjct: 227 ANVS------------AVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQH 272 >3LMG-A nrPDB Length = 344 Score = 198 bits (502), Expect = 5e-51, Method: Composition-based stats. Identities = 66/298 (22%), Positives = 126/298 (42%), Gaps = 30/298 (10%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL-NQEGFQGHREWLT 120 R V+G G FG V KG P + + +K + ++ G Q + Sbjct: 28 FKETELRKLKVLGSGVFGTVHKG-----VWIPEGESIKIPVCIKVIEDKSGRQSFQAVTD 82 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 + +G L H ++V+L+G C LV +++ GSL +H+ + P L +N Sbjct: 83 HMLAIGSLDHAHIVRLLGLCP-GSSLQLVTQYLPLGSLLDHVRQHRGALGP---QLLLNW 138 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 + AKG+ +L +++R++ A N+LL + +++DFG+A P D + + Sbjct: 139 GVQIAKGMYYLEEH--GMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAK 196 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLT 299 + A E + G +SDV+S+GV + E+++ G R A+ +L++ Sbjct: 197 TPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEK------ 250 Query: 300 SKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLG 357 RL + + + V V+C + RPT ++ ++ + Sbjct: 251 ---------GERLAQPQI--CTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPP 297 >5KKR-C nrPDB Length = 395 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 71/313 (22%), Positives = 129/313 (41%), Gaps = 45/313 (14%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWL 119 +L +F S +G G G VFK + +GLV+A K ++ E R + + Sbjct: 64 ELKDDDFEKISELGAGNGGVVFK---------VSHKPSGLVMARKLIHLEIKPAIRNQII 114 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 E+ L + + P +V G D + E M GSL+ L + G +P + Sbjct: 115 RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR----IPEQILGK 170 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 V++ KGL +L K+++RD+K SNIL+++ KL DFG++ + ++ Sbjct: 171 VSIAVIKGLTYLREK-HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL----IDSMANSF 225 Query: 240 MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDW------ 293 +GT Y +PE + H + +SD++S G+ L+E+ G+ + + E + Sbjct: 226 VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDA 285 Query: 294 --------------------ARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLS 333 +RP + + IV+ ++ +CL Sbjct: 286 AETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLI 345 Query: 334 FEPKSRPTMDQVV 346 P R + Q++ Sbjct: 346 KNPAERADLKQLM 358 >3TKU-A nrPDB Length = 433 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 59/268 (22%), Positives = 100/268 (37%), Gaps = 25/268 (9%) Query: 53 KSFT--FNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE 110 K FT E++L +F VIG G FG V T + A+K LN+ Sbjct: 76 KPFTQLVKEMQLHREDFEIIKVIGRGAFGEV---------AVVKMKNTERIYAMKILNKW 126 Query: 111 GFQGHRE---WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGA 167 E + E + L + L ++ H LV ++ G L L + Sbjct: 127 EMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSK--- 183 Query: 168 YFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG 227 + LP + + + +H + ++RDIK N+LLD + + +L+DFG Sbjct: 184 FEDKLPEDMARFYIGEMVLAIDSIHQ--LHYVHRDIKPDNVLLDVNGHIRLADFGSCLKM 241 Query: 228 PMGDLSYVSTRVMGTYGYAAPEYMSS-----GHLNARSDVYSFGVLLLEILSGKRALDHN 282 D + S+ +GT Y +PE + + G D +S GV + E+L G+ Sbjct: 242 N-DDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAE 300 Query: 283 RPAKEENLVDWARPYLTSKRKVLLIVDN 310 + + V + + Sbjct: 301 SLVETYGKIMNHEERFQFPSHVTDVSEE 328 >4JG6-A nrPDB Length = 355 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 64/307 (20%), Positives = 116/307 (37%), Gaps = 37/307 (12%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEIN 123 T + IG G + + T + AVK +++ R+ EI Sbjct: 34 TDGYEVKEDIGVGSYSVCKRC---------IHKATNMEFAVKIIDK----SKRDPTEEIE 80 Query: 124 YLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 L + HPN++ L + ++ +V E M+ G L + + R+ + + V Sbjct: 81 ILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREA----SAVLF 136 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNIL-LDADYN---AKLSDFGLARDGPMGDLSYVSTR 238 K + +LH+ V++RD+K SNIL +D N ++ DFG A+ + ++ Sbjct: 137 TITKTVEYLHAQ--GVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTP- 193 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 T + APE + +A D++S GVLL +L+G + E ++ Sbjct: 194 -CYTANFVAPEVLERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILAR----- 247 Query: 299 TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGK 358 + L Y + + + L +P R T V+R + + Sbjct: 248 ------IGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLP 301 Query: 359 PSQTNPV 365 Q N Sbjct: 302 QYQLNRQ 308 >2YAB-A nrPDB Length = 361 Score = 197 bits (501), Expect = 7e-51, Method: Composition-based stats. Identities = 64/298 (21%), Positives = 114/298 (38%), Gaps = 42/298 (14%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR---- 116 + + +G G F V K + TGL A K + + + R Sbjct: 8 QKVEDFYDIGEELGSGQFAIVKKC---------REKSTGLEYAAKFIKKRQSRASRRGVC 58 Query: 117 --EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPW 174 E E++ L Q+ HPN++ L +L+ E + G L + L ++ + + Sbjct: 59 REEIEREVSILRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEAT 118 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY----NAKLSDFGLARDGPMG 230 G+ +LH+ K+ + D+K NI+L + KL DFGLA + G Sbjct: 119 S----FIKQILDGVNYLHTK--KIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDG 172 Query: 231 DLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENL 290 + GT + APE ++ L +D++S GV+ +LSG + K+E L Sbjct: 173 ---VEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGD--TKQETL 227 Query: 291 VDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + V D ++ + + + L E + R T+ + +R Sbjct: 228 ANIT------------AVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRH 273 >4I94-A nrPDB Length = 300 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 92/310 (29%), Positives = 156/310 (50%), Gaps = 28/310 (9%) Query: 48 SSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL 107 SS + F+ ++ AT F ++++ E G + + K IAVK+ Sbjct: 9 SSGQFREFSIETIRNATSGFAAENIVSE-------HGERAPNVVYKGKLENQRRIAVKRF 61 Query: 108 NQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGA 167 N++ + R++L E +GQL + + L+G C EDE RLL+ EFM +L HLF + Sbjct: 62 NRKSWPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEERLLIAEFMPNETLAKHLFHWES 121 Query: 168 YFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG 227 +P+ W +R+ VAL A+ L + S + + D+ A +L D D N +LS FGL ++ Sbjct: 122 --QPMKWAMRLRVALHIAQALEYCTSKGRALYH-DLNAYRVLFDDDANPRLSCFGLMKNS 178 Query: 228 PMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE 287 G + + PEY+ +G + S +YSFG LLL++LSGK H P+ Sbjct: 179 RDGKSYSTN------LAFTPPEYLRTGRVTPESVIYSFGTLLLDLLSGK----HIPPSHA 228 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 +L+ R + +++D+ L+ Q+ ++ + +A +CL +EP+ RP +V Sbjct: 229 LDLI--------RDRNIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRERPNPKSLVS 280 Query: 348 ALQQLQDNLG 357 A+ LQ +L Sbjct: 281 AMIPLQKDLE 290 >6CMJ-A nrPDB Length = 321 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 68/300 (22%), Positives = 124/300 (41%), Gaps = 50/300 (16%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH------ 115 + + IG+G +G V + + A+K L+++ Sbjct: 31 VQLDQYTLKDEIGKGSYGVVKLAYNEND---------NTYYAMKVLSKKKLIRQAGGCIQ 81 Query: 116 -----REWLTEINYLGQLSHPNLVKLIGYCLE--DEHRLLVYEFMQKGSLENHLFRRGAY 168 + EI L +L HPN+VKL+ + ++H +V+E + +G + Sbjct: 82 PRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEV-----PT 136 Query: 169 FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGP 228 KPL D KG+ +LH K+I+RDIK SN+L+ D + K++DFG++ + Sbjct: 137 LKPLSEDQARFYFQDLIKGIEYLHYQ--KIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK 194 Query: 229 MGDLSYVSTRVMGTYGYAAPEYMSSGH--LNARS-DVYSFGVLLLEILSGKRALDHNRPA 285 D +T +GT + APE +S + ++ DV++ GV L + G+ R Sbjct: 195 GSDALLSNT--VGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIM 252 Query: 286 KEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQV 345 + + K + L D P+ A + + + L P+SR + ++ Sbjct: 253 CLHSKI---------KSQALEFPDQ-------PDIAEDLKDLITRMLDKNPESRIVVPEI 296 >5AWM-A nrPDB Length = 394 Score = 197 bits (500), Expect = 9e-51, Method: Composition-based stats. Identities = 66/346 (19%), Positives = 123/346 (35%), Gaps = 55/346 (15%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTEI 122 + IG G G V + T +A+KKL++ + + E Sbjct: 44 SRYINLRPIGSGAQGIVCAAY---------DTITQQNVAIKKLSRPFQNVTHAKRAYREF 94 Query: 123 NYLGQLSHPNLVKLIGYCL------EDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 + ++H N++ L+ E + LV E M +L + L Sbjct: 95 KLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVIQM------DLDHDR 147 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 + G+ LHS +I+RD+K SNI++ AD K+ DFGLAR +++ Sbjct: 148 MSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVKADCTLKILDFGLARTAG---TTFMM 202 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDH--------------- 281 T + T Y APE + D++S G ++ E++ G Sbjct: 203 TPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLG 262 Query: 282 -NRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYL-PEE--------AVRMASVAVQC 331 P+ + L R Y+ ++ + +RL L P + A ++ + Sbjct: 263 TPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKM 322 Query: 332 LSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVKDTKKLGFKTGT 377 L +P+ R ++D+ ++ + + P + Sbjct: 323 LVIDPEQRISVDEALKH-EYINVWYDAEEVDAPAPEPYDHSVDERE 367 >2OU7-A nrPDB Length = 335 Score = 197 bits (500), Expect = 9e-51, Method: Composition-based stats. Identities = 65/279 (23%), Positives = 112/279 (40%), Gaps = 38/279 (13%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE---GFQGHREWLTEINYLGQLS 129 +G+GGF F+ + T V A K + + + EI+ L+ Sbjct: 49 LGKGGFAKCFE---------ISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLA 99 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 H ++V G+ +++ +V E ++ SL RR A +P + G Sbjct: 100 HQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARY----YLRQIVLGCQ 155 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPE 249 +LH + +VI+RD+K N+ L+ D K+ DFGLA + GT Y APE Sbjct: 156 YLHRN--RVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYD--GERKKVLCGTPNYIAPE 211 Query: 250 YMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVD 309 +S + DV+S G ++ +L GK + YL K+ I Sbjct: 212 VLSKKGHSFEVDVWSIGCIMYTLLVGKPPFE---------TSCLKETYLRIKKNEYSIPK 262 Query: 310 NRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + AS+ + L +P +RPT+++++ Sbjct: 263 H---------INPVAASLIQKMLQTDPTARPTINELLND 292 >4B8L-A nrPDB Length = 286 Score = 197 bits (500), Expect = 9e-51, Method: Composition-based stats. Identities = 68/303 (22%), Positives = 115/303 (37%), Gaps = 37/303 (12%) Query: 44 GEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIA 103 L+ P + FT + +F +G+G FG V+ + ++A Sbjct: 1 ATALAEMPKRKFTID-------DFDIGRPLGKGKFGNVYLA---------REKQNKFIMA 44 Query: 104 VKKLNQEGFQGH---REWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLEN 160 +K L + + + EI L HPN++++ Y + + L+ EF +G L Sbjct: 45 LKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYK 104 Query: 161 HLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSD 220 L + G + + + A L + H KVI+RDIK N+L+ K++D Sbjct: 105 ELQKHGRFDEQRS----ATFMEELADALHYCHER--KVIHRDIKPENLLMGYKGELKIAD 158 Query: 221 FGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 FG + P S + GT Y PE + + + D++ GVL E L G D Sbjct: 159 FGWSVHAP----SLRRRTMCGTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFD 214 Query: 281 HNRPA----KEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEP 336 + N+ P+L+ K L+ R Y P + + + V Sbjct: 215 SPSHTETHRRIVNVDLKFPPFLSDGSKDLISKLLR----YHPPQRLPLKGVMEHPWVKAN 270 Query: 337 KSR 339 R Sbjct: 271 SRR 273 >4J52-A nrPDB Length = 293 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 65/279 (23%), Positives = 112/279 (40%), Gaps = 38/279 (13%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE---GFQGHREWLTEINYLGQLS 129 +G+GGF F+ + T V A K + + + EI+ L+ Sbjct: 22 LGKGGFAKCFE---------ISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLA 72 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 H ++V G+ +++ +V E ++ SL RR A +P + G Sbjct: 73 HQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARY----YLRQIVLGCQ 128 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPE 249 +LH + +VI+RD+K N+ L+ D K+ DFGLA + GT Y APE Sbjct: 129 YLHRN--RVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYD--GERKKVLCGTPNYIAPE 184 Query: 250 YMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVD 309 +S + DV+S G ++ +L GK + YL K+ I Sbjct: 185 VLSKKGHSFEVDVWSIGCIMYTLLVGKPPFE---------TSCLKETYLRIKKNEYSIPK 235 Query: 310 NRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + AS+ + L +P +RPT+++++ Sbjct: 236 H---------INPVAASLIQKMLQTDPTARPTINELLND 265 >3EQC-A nrPDB Length = 360 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 71/313 (22%), Positives = 128/313 (40%), Gaps = 45/313 (14%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWL 119 +L +F S +G G G VFK + +GLV+A K ++ E R + + Sbjct: 29 ELKDDDFEKISELGAGNGGVVFK---------VSHKPSGLVMARKLIHLEIKPAIRNQII 79 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 E+ L + + P +V G D + E M GSL+ L + G +P + Sbjct: 80 RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR----IPEQILGK 135 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 V++ KGL +L K+++RD+K SNIL+++ KL DFG++ + ++ Sbjct: 136 VSIAVIKGLTYLREK-HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL----IDSMANSF 190 Query: 240 MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEE----------- 288 +GT Y +PE + H + +SD++S G+ L+E+ G+ + + E Sbjct: 191 VGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDA 250 Query: 289 ---------------NLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLS 333 +RP + + IV+ ++ +CL Sbjct: 251 AETPPRPRTPGRPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLI 310 Query: 334 FEPKSRPTMDQVV 346 P R + Q++ Sbjct: 311 KNPAERADLKQLM 323 >5G6V-A nrPDB Length = 324 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 62/299 (20%), Positives = 125/299 (41%), Gaps = 31/299 (10%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWLTEI 122 + +GEG + V+KG T ++A+K++ E +G + E+ Sbjct: 1 METYIKLDKLGEGTYATVYKGKS---------KLTDNLVALKEIRLEHEEGAPCTAIREV 51 Query: 123 NYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 + L L H N+V L ++ LV+E++ K L+ +L G + Sbjct: 52 SLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDK-DLKQYLDDCGNI---INMHNVKLFLF 107 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 +GLA+ H KV++RD+K N+L++ KL+DFGLAR + +Y + T Sbjct: 108 QLLRGLAYCHRQ--KVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY--DNEVVT 163 Query: 243 YGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV--------DW 293 Y P+ + + + D++ G + E+ +G+ + ++ + + + Sbjct: 164 LWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEE 223 Query: 294 ARPYLTSKRKVLLIVDNRLDTQYLPEEAVRM----ASVAVQCLSFEPKSRPTMDQVVRA 348 P + S + + + L A R+ A + + L FE ++R + + ++ Sbjct: 224 TWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKH 282 >4FL3-A nrPDB Length = 635 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 68/288 (23%), Positives = 116/288 (40%), Gaps = 35/288 (12%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG--HREWLTEINYLGQ 127 D +G G FG V KG+ + T L E E L E N + Q Sbjct: 374 DKELGSGNFGTVKKGYYQMKKVVKTVAVK-------ILKNEANDPALKDELLAEANVMQQ 426 Query: 128 LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 L +P +V++IG C E E +LV E + G L +L + + + + G Sbjct: 427 LDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDK----NIIELVHQVSMG 481 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS-TRVMGTYGYA 246 + +L ++RD+ A N+LL + AK+SDFGL++ + Y + T + Sbjct: 482 MKYLEES--NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 539 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLTSKRKVL 305 APE ++ +++SDV+SFGVL+ E S G++ +V Sbjct: 540 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG-----------------MKGSEVT 582 Query: 306 LIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQ 353 +++ M + C +++ ++RP V L+ Sbjct: 583 AMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 630 >3LM0-A nrPDB Length = 327 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 65/341 (19%), Positives = 126/341 (36%), Gaps = 40/341 (11%) Query: 53 KSFTFNELKLATRNFRP-DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE- 110 ++ F ++ + +G G F V + TG A K L + Sbjct: 16 ENLYFQSMENFNNFYILTSKELGRGKFAVVRQC---------ISKSTGQEYAAKFLKKRR 66 Query: 111 -GFQGHREWLTEINYLGQLSH-PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAY 168 G E L EI L P ++ L +L+ E+ G + + Sbjct: 67 RGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCL--PEL 124 Query: 169 FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLAR 225 + + + + +G+ +LH + +++ D+K NILL + + K+ DFG++R Sbjct: 125 AEMVSENDVIRLIKQILEGVYYLHQN--NIVHLDLKPQNILLSSIYPLGDIKIVDFGMSR 182 Query: 226 DGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPA 285 +G + +MGT Y APE ++ + +D+++ G++ +L+ Sbjct: 183 K--IGHACELRE-IMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGE--- 236 Query: 286 KEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQV 345 D YL + V+ + + L P+ RPT + Sbjct: 237 ------DNQETYLN-----ISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEIC 285 Query: 346 VRA--LQQLQ-DNLGKPSQTNPVKDTKKLGFKTGTTKSSEK 383 + LQQ +NL P +T+ T+ ++ K+S+ Sbjct: 286 LSHSWLQQWDFENLFHPEETSSSSQTQDHSVRSSEDKTSKS 326 >2BUJ-A nrPDB Length = 317 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 69/326 (21%), Positives = 121/326 (37%), Gaps = 44/326 (13%) Query: 54 SFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ 113 F + + + +++ +GEGGF V G A+K++ Q Sbjct: 18 YFQGHMVIIDNKHYLFIQKLGEGGFSYV---------DLVEGLHDGHFYALKRILCHEQQ 68 Query: 114 GHREWLTEINYLGQLSHPNLVKLIGYCLED----EHRLLVYEFMQKGSLENHLFRRGAYF 169 E E + +HPN+++L+ YCL + L+ F ++G+L N + R Sbjct: 69 DREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKG 128 Query: 170 KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG-- 227 L + + L +GL +H+ +RD+K +NILL + L D G Sbjct: 129 NFLTEDQILWLLLGICRGLEAIHAK--GYAHRDLKPTNILLGDEGQPVLMDLGSMNQACI 186 Query: 228 -------PMGDLSYVSTRVMGTYGYAAPEYMSSGHL---NARSDVYSFGVLLLEILSGKR 277 + + + R T Y APE S + R+DV+S G +L ++ G+ Sbjct: 187 HVEGSRQALTLQDWAAQRC--TISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEG 244 Query: 278 ALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPK 337 D V L V N+L P + + + ++ +P Sbjct: 245 PYDM---------------VFQKGDSVALAVQNQLSIPQSPRHSSALWQLLNSMMTVDPH 289 Query: 338 SRPTMDQVVRALQQLQDNLGKPSQTN 363 RP + ++ L+ LQ T Sbjct: 290 QRPHIPLLLSQLEALQPPAPGQHTTQ 315 >2A27-A nrPDB Length = 321 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 64/307 (20%), Positives = 118/307 (38%), Gaps = 45/307 (14%) Query: 52 VKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEG 111 ++ F +++ + +G G F V K + TGL A K + + Sbjct: 2 MEPFKQQKVE---DFYDIGEELGSGQFAIVKKC---------REKSTGLEYAAKFIKKRQ 49 Query: 112 FQGHR------EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR 165 + R E E++ L Q+ H N++ L +L+ E + G L + L ++ Sbjct: 50 SRASRRGVSREEIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQK 109 Query: 166 GAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY----NAKLSDF 221 + + G+ +LH+ K+ + D+K NI+L + KL DF Sbjct: 110 ESLSEEEATS----FIKQILDGVNYLHTK--KIAHFDLKPENIMLLDKNIPIPHIKLIDF 163 Query: 222 GLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDH 281 GLA + G + GT + APE ++ L +D++S GV+ +LSG Sbjct: 164 GLAHEIEDG---VEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLG 220 Query: 282 NRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPT 341 + K+E L + V D ++ + + + L E + R T Sbjct: 221 D--TKQETLANIT------------AVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLT 266 Query: 342 MDQVVRA 348 + + +R Sbjct: 267 IQEALRH 273 >5C26-A nrPDB Length = 299 Score = 194 bits (494), Expect = 5e-50, Method: Composition-based stats. Identities = 68/288 (23%), Positives = 116/288 (40%), Gaps = 35/288 (12%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG--HREWLTEINYLGQ 127 D +G G FG V KG+ + T L E E L E N + Q Sbjct: 32 DKELGSGNFGTVKKGYYQMKKVVKTVAVK-------ILKNEANDPALKDELLAEANVMQQ 84 Query: 128 LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 L +P +V++IG C E E +LV E + G L +L + + + + G Sbjct: 85 LDNPYIVRMIGIC-EAESWMLVMEMAELGPLNKYLQQNRHVKDK----NIIELVHQVSMG 139 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS-TRVMGTYGYA 246 + +L ++RD+ A N+LL + AK+SDFGL++ + Y + T + Sbjct: 140 MKYLEES--NFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWY 197 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWARPYLTSKRKVL 305 APE ++ +++SDV+SFGVL+ E S G++ +V Sbjct: 198 APECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRG-----------------MKGSEVT 240 Query: 306 LIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQ 353 +++ M + C +++ ++RP V L+ Sbjct: 241 AMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 288 >3NYO-A nrPDB Length = 576 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 76/331 (22%), Positives = 127/331 (38%), Gaps = 43/331 (12%) Query: 30 RKSSSTVAAAQKTEGEILSSTPVKSFTFNELK----LATRNFRPDSVIGEGGFGCVFKGW 85 + + + + L S F + + FR V+G+GGFG V Sbjct: 146 TRLTHEYLSVA-PFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQ 204 Query: 86 LDESTLTPTKPGTGLVIAVKKLNQEGFQ---GHREWLTEINYLGQLSHPNLVKLIGYCLE 142 + TG + A KKL ++ + G L E L +++ +V L Sbjct: 205 V---------RATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYET 255 Query: 143 DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRD 202 + LV M G L+ H++ G P V A + GL LH + +++YRD Sbjct: 256 KDALCLVLTLMNGGDLKFHIYHMGQAGFPEAR--AVFYAAEICCGLEDLHRE--RIVYRD 311 Query: 203 IKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDV 262 +K NILLD + ++SD GLA P G +GT GY APE + + D Sbjct: 312 LKPENILLDDHGHIRISDLGLAVHVPEGQT---IKGRVGTVGYMAPEVVKNERYTFSPDW 368 Query: 263 YSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAV 322 ++ G LL E+++G+ + KR+ + + + +Y + Sbjct: 369 WALGCLLYEMIAGQSPFQQRK--------------KKIKREEVERLVKEVPEEYSERFSP 414 Query: 323 RMASVAVQCLSFEPKSRP-----TMDQVVRA 348 + S+ Q L +P R + +V Sbjct: 415 QARSLCSQLLCKDPAERLGCRGGSAREVKEH 445 >1ZWS-A nrPDB Length = 288 Score = 193 bits (491), Expect = 1e-49, Method: Composition-based stats. Identities = 64/307 (20%), Positives = 117/307 (38%), Gaps = 45/307 (14%) Query: 52 VKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEG 111 ++ F +++ + +G G F V K + TGL A K + + Sbjct: 2 MEPFKQQKVE---DFYDIGEELGSGQFAIVKKC---------REKSTGLEYAAKFIKKRQ 49 Query: 112 FQGHR------EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRR 165 + R E E++ L Q+ H N++ L +L+ E + G L + L ++ Sbjct: 50 SRASRRGVSREEIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQK 109 Query: 166 GAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY----NAKLSDF 221 + + G+ +LH+ K+ + D+K NI+L + KL DF Sbjct: 110 ESLSEEEATS----FIKQILDGVNYLHTK--KIAHFDLKPENIMLLDKNIPIPHIKLIDF 163 Query: 222 GLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDH 281 GLA + G + GT + APE ++ L +D++S GV+ +LSG Sbjct: 164 GLAHEIEDG---VEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLG 220 Query: 282 NRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPT 341 + K+E L + V D ++ + + L E + R T Sbjct: 221 D--TKQETLANITS------------VSYDFDEEFFSHTSELAKDFIRKLLVKETRKRLT 266 Query: 342 MDQVVRA 348 + + +R Sbjct: 267 IQEALRH 273 >2YCR-A nrPDB Length = 323 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 71/339 (20%), Positives = 135/339 (39%), Gaps = 46/339 (13%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ--GHREW--- 118 + +G G G V + + T +A+K +++ F RE Sbjct: 9 RDEYIMSKTLGSGACGEVKLAF---------ERKTCKKVAIKIISKRKFAIGSAREADPA 59 Query: 119 ---LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 TEI L +L+HP ++K+ + + E +V E M+ G L + + K L Sbjct: 60 LNVETEIEILKKLNHPCIIKIKNFF-DAEDYYIVLELMEGGELFDKVV----GNKRLKEA 114 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLD---ADYNAKLSDFGLARDGPMGDL 232 + +LH + +I+RD+K N+LL D K++DFG ++ +G+ Sbjct: 115 TCKLYFYQMLLAVQYLHEN--GIIHRDLKPENVLLSSQEEDCLIKITDFGHSK--ILGET 170 Query: 233 SYVSTRVMGTYGYAAPEYM---SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEEN 289 S + T + GT Y APE + + N D +S GV+L LSG + Sbjct: 171 SLMRT-LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEH------- 222 Query: 290 LVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRAL 349 R ++ K ++ N + + E + + + + L +PK+R T ++ +R Sbjct: 223 -----RTQVSLKDQITSGKYNFIPEVWA-EVSEKALDLVKKLLVVDPKARFTTEEALRHP 276 Query: 350 QQLQDNLGKPSQTNPVKDTKKLGFKTGTTKSSEKRFTQK 388 +++ + Q ++ + + S R + Sbjct: 277 WLQDEDMKRKFQDLLSEENESTAKPQVLAQPSTSRKRPR 315 >5AP3-A nrPDB Length = 313 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 65/331 (19%), Positives = 125/331 (37%), Gaps = 49/331 (14%) Query: 53 KSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE-- 110 ++ F + + R + IG GG VF+ ++ + A+K +N E Sbjct: 16 ENLYFQSMSVKGRIYSILKQIGSGGSSKVFQVLNEK----------KQIYAIKYVNLEEA 65 Query: 111 GFQGHREWLTEINYLGQLS--HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAY 168 Q + EI YL +L +++L Y + D++ +V E L L ++ Sbjct: 66 DNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNGWLKKK--- 121 Query: 169 FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGP 228 K + + R + + + + +H +++ D+K +N L+ D KL DFG+A Sbjct: 122 -KSIDPWERKSYWKNMLEAVHTIHQH--GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQ 177 Query: 229 MGDLSYVSTRVMGTYGYAAPEYMSSGHLNAR-----------SDVYSFGVLLLEILSGKR 277 S V +GT Y PE + + SDV+S G +L + GK Sbjct: 178 PDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKT 237 Query: 278 ALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPK 337 + + K+ I+D + ++ + V CL +PK Sbjct: 238 PF---------------QQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPK 282 Query: 338 SRPTMDQVVRA-LQQLQDNLGKPSQTNPVKD 367 R ++ +++ Q+Q + ++ Sbjct: 283 QRISIPELLAHPYVQIQTHPVNQMAKGTTEE 313 >4TNB-A nrPDB Length = 590 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 76/302 (25%), Positives = 121/302 (40%), Gaps = 37/302 (12%) Query: 45 EILSSTPVKSFTFNELK----LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGL 100 E L S F + + FR V+G+GGFG V + TG Sbjct: 160 EYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQV---------RATGK 210 Query: 101 VIAVKKLNQEGFQGHR---EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGS 157 + A K+L ++ + + L E L +++ +V L + LV M G Sbjct: 211 MYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGD 270 Query: 158 LENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAK 217 L+ H++ G + A + GL LH + +YRD+K NILLD + + Sbjct: 271 LKFHIYNMGNPGFEEER--ALFYAAEILCGLEDLHHE--NTVYRDLKPENILLDDYGHIR 326 Query: 218 LSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKR 277 +SD GLA P GDL +GT GY APE +++ D + G L+ E++ G+ Sbjct: 327 ISDLGLAVKIPEGDLIR---GRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQS 383 Query: 278 ALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPK 337 + + VD R+VL + + EEA + + L+ + K Sbjct: 384 PFRGRKEKVKREEVD---------RRVLET--EEVYSHKFSEEAKSICKML---LTKDAK 429 Query: 338 SR 339 R Sbjct: 430 QR 431 >5YV8-A nrPDB Length = 298 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 68/315 (21%), Positives = 124/315 (39%), Gaps = 65/315 (20%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH------ 115 + + IG+G +G V + + A+K L+++ Sbjct: 10 VQLNQYTLKDEIGKGSYGVVKLAYNEND---------NTYYAMKVLSKKKLIRQAGFPRR 60 Query: 116 --------------------REWLTEINYLGQLSHPNLVKLIGYCLE--DEHRLLVYEFM 153 + EI L +L HPN+VKL+ + ++H +V+E + Sbjct: 61 PPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELV 120 Query: 154 QKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD 213 +G + KPL D KG+ +LH K+I+RDIK SN+L+ D Sbjct: 121 NQGPVMEV-----PTLKPLSEDQARFYFQDLIKGIEYLHYQ--KIIHRDIKPSNLLVGED 173 Query: 214 YNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGH--LNARS-DVYSFGVLLL 270 + K++DFG++ + D +T +GT + APE +S + ++ DV++ GV L Sbjct: 174 GHIKIADFGVSNEFKGSDALLSNT--VGTPAFMAPESLSETRKIFSGKALDVWAMGVTLY 231 Query: 271 EILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQ 330 + G+ R + + K + L D P+ A + + + Sbjct: 232 CFVFGQCPFMDERIMCLHSKI---------KSQALEFPDQ-------PDIAEDLKDLITR 275 Query: 331 CLSFEPKSRPTMDQV 345 L P+SR + ++ Sbjct: 276 MLDKNPESRIVVPEI 290 >3OZ6-A nrPDB Length = 388 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 74/338 (21%), Positives = 128/338 (37%), Gaps = 71/338 (21%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTEI 122 R + +G+G +G V+K TG V+AVKK+ + + EI Sbjct: 9 RKYELVKKLGKGAYGIVWK---------SIDRRTGEVVAVKKIFDAFQNSTDAQRTFREI 59 Query: 123 NYLGQLS-HPNLVKLIGYCL--EDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 L +LS H N+V L+ D LV+++M+ L + R +P+ + Sbjct: 60 MILTELSGHENIVNLLNVLRADNDRDVYLVFDYMET-DLHAVI--RANILEPV---HKQY 113 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG------------ 227 V K + +LHS +++RD+K SNILL+A+ + K++DFGL+R Sbjct: 114 VVYQLIKVIKYLHS--GGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPL 171 Query: 228 -------PMGDLSYVSTRVMGTYGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSGKRAL 279 D + T + T Y APE + D++S G +L EIL GK Sbjct: 172 SINENTENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIF 231 Query: 280 DHNRPAKE-------------ENLVDWARPY--------------LTSKRKVLLIVDNRL 312 + + E++ P+ S ++ + L Sbjct: 232 PGSSTMNQLERIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNL 291 Query: 313 DTQYLP--EEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + P + + + L F P R + + ++ Sbjct: 292 LLKINPKADCNEEALDLLDKLLQFNPNKRISANDALKH 329 >4EQM-A nrPDB Length = 294 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 64/310 (20%), Positives = 133/310 (42%), Gaps = 38/310 (12%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL---NQEGFQGHRE 117 K+ ++ +G GG V+ + +A+K + +E + + Sbjct: 7 KIINERYKIVDKLGGGGMSTVYLA---------EDTILNIKVAIKAIFIPPREKEETLKR 57 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 + E++ QLSH N+V +I ED+ LV E+++ +L ++ G PL Sbjct: 58 FEREVHNSSQLSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHG----PLSVDTA 113 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 +N G+ H+ +++++RDIK NIL+D++ K+ DFG+A+ L+ + Sbjct: 114 INFTNQILDGIK--HAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLT-QTN 170 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY 297 V+GT Y +PE + +D+YS G++L E+L G+ + Sbjct: 171 HVLGTVQYFSPEQAKGEATDECTDIYSIGIVLYEMLVGEPPFNGET-------------A 217 Query: 298 LTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLG 357 ++ K + + T + +++V ++ + +R + +Q+++D+L Sbjct: 218 VSIAIKHIQDSVPNVTTDVRKDIPQSLSNVILRATEKDKANR------YKTIQEMKDDLS 271 Query: 358 KPSQTNPVKD 367 N + Sbjct: 272 SVLHENRANE 281 >6BXI-A nrPDB Length = 333 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 64/280 (22%), Positives = 99/280 (35%), Gaps = 51/280 (18%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE--- 117 +L +F VIG G FG V K TG V A+K L + + Sbjct: 2 RLGLEDFESLKVIGRGAFGEV---------RLVQKKDTGHVYAMKILRKADMLEKEQVGH 52 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 E + L + +VK+ + + L+ EF+ G + L ++ + F Sbjct: 53 IRAERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYI 112 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLA------------- 224 L + +H + I+RDIK N+LLD+ + KLSDFGL Sbjct: 113 AETVL----AIDSIHQ--LGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYR 166 Query: 225 --RDGPMGDLSYVST------------------RVMGTYGYAAPEYMSSGHLNARSDVYS 264 D ++ + +GT Y APE N D +S Sbjct: 167 NLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWS 226 Query: 265 FGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKV 304 GV++ E+L G P + V + LT +V Sbjct: 227 LGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEV 266 >2XS0-A nrPDB Length = 386 Score = 191 bits (484), Expect = 6e-49, Method: Composition-based stats. Identities = 70/381 (18%), Positives = 133/381 (34%), Gaps = 61/381 (16%) Query: 44 GEILSSTPVKSFTFNELKLAT----RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTG 99 G + S +F E+ +T + ++ IG G G V + Sbjct: 1 GSMSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAY---------DAILE 51 Query: 100 LVIAVKKLNQ--EGFQGHREWLTEINYLGQLSHPNLVKLIGYCL------EDEHRLLVYE 151 +A+KKL++ + + E+ + ++H N++ L+ E + +V E Sbjct: 52 RNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVME 111 Query: 152 FMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLD 211 M +L + L + G+ LHS +I+RD+K SNI++ Sbjct: 112 LMDA-NLCQVIQM------ELDHERMSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVK 162 Query: 212 ADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLE 271 +D K+ DFGLAR S++ + T Y APE + D++S G ++ E Sbjct: 163 SDCTLKILDFGLARTAG---TSFMMVPFVVTRYYRAPEVILGMGYKENVDIWSVGCIMGE 219 Query: 272 ILSGKRALDHNR----------------PAKEENLVDWARPYLTSKRKVLLIVDNRLDTQ 315 ++ G P + L R Y+ ++ K +L Sbjct: 220 MIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPD 279 Query: 316 YL-PEEA-------VRMASVAVQCLSFEPKSRPTMDQVVRA--LQQLQDNL--GKPSQTN 363 L P ++ + + + L + R ++D+ ++ + D P Sbjct: 280 VLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKI 339 Query: 364 PVKDTKKLGFKTGTTKSSEKR 384 P K + K + Sbjct: 340 PDKQLDEREHTIEEWKELIYK 360 >1S9I-A nrPDB Length = 354 Score = 190 bits (483), Expect = 7e-49, Method: Composition-based stats. Identities = 68/312 (21%), Positives = 125/312 (40%), Gaps = 53/312 (16%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWL 119 +L +F S +G G G V K +GL++A K ++ E R + + Sbjct: 12 ELKDDDFERISELGAGNGGVVTK---------VQHRPSGLIMARKLIHLEIKPAIRNQII 62 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 E+ L + + P +V G D + E M GSL+ L K +P + Sbjct: 63 RELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKE----AKRIPEEILGK 118 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 V++ +GLA+L ++++RD+K SNIL+++ KL DFG++ + ++ Sbjct: 119 VSIAVLRGLAYLREK-HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQL----IDSMANSF 173 Query: 240 MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLT 299 +GT Y APE + H + +SD++S G+ L+E+ G+ + P +E + RP + Sbjct: 174 VGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIP--PPDAKELEAIFGRPVVD 231 Query: 300 SKRK---------------------------VLLIVDNRLDTQYLPEEA-----VRMASV 327 + + + + + + P+ Sbjct: 232 GEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEF 291 Query: 328 AVQCLSFEPKSR 339 +CL P R Sbjct: 292 VNKCLIKNPAER 303 >1PY5-A nrPDB Length = 326 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 79/324 (24%), Positives = 129/324 (39%), Gaps = 49/324 (15%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 + R IG+G FG V++G G +AVK + + R W Sbjct: 25 RTIARTIVLQESIGKGRFGEVWRGKWR-----------GEEVAVKIFSS---REERSWFR 70 Query: 121 EINYLG--QLSHPNLVKLIGYCLEDE----HRLLVYEFMQKGSLENHLFRRGAYFKPLPW 174 E L H N++ I +D LV ++ + GSL ++L R + + Sbjct: 71 EAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGM-- 128 Query: 175 FLRVNVALDAAKGLAFLH------SDPVKVIYRDIKASNILLDADYNAKLSDFGLA--RD 226 + +AL A GLA LH + +RD+K+ NIL+ + ++D GLA D Sbjct: 129 ---IKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHD 185 Query: 227 GPMGDLSYVSTRVMGTYGYAAPEYMSS----GHLN--ARSDVYSFGVLLLEILS----GK 276 + +GT Y APE + H R+D+Y+ G++ EI G Sbjct: 186 SATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGG 245 Query: 277 RALDHNRPAKEENLVDWARPYLTSKRKVLLI--VDNRLDTQYLPEEAVR-MASVAVQCLS 333 D+ P + D P + RKV+ + + ++ EA+R MA + +C Sbjct: 246 IHEDYQLPYYDLVPSD---PSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWY 302 Query: 334 FEPKSRPTMDQVVRALQQLQDNLG 357 +R T ++ + L QL G Sbjct: 303 ANGAARLTALRIKKTLSQLSQQEG 326 >4IDT-A nrPDB Length = 356 Score = 190 bits (482), Expect = 9e-49, Method: Composition-based stats. Identities = 85/362 (23%), Positives = 136/362 (37%), Gaps = 58/362 (16%) Query: 1 MGSCFSSRVKADIFHNGKSSDLYGLS-----------LSSRKSSSTVAAAQKTEGEILSS 49 MGS FS V+ + H + S G + +S + EG +L+ Sbjct: 3 MGSKFS--VEEYLVHALQGSVSSGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGVLLTE 60 Query: 50 T--PVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL 107 PV E+ AT R +G G FG V + TG AVKK+ Sbjct: 61 KLKPVDYEYREEVHWATHQLR----LGRGSFGEVHR---------MEDKQTGFQCAVKKV 107 Query: 108 NQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGA 167 E F+ E+ L+ P +V L G E + E ++ GSL + +G Sbjct: 108 RLEVFRAE-----ELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGC 162 Query: 168 YFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY-NAKLSDFGLARD 226 LP + A +GL +LHS ++++ D+KA N+LL +D +A L DFG A Sbjct: 163 ----LPEDRALYYLGQALEGLEYLHSR--RILHGDVKADNVLLSSDGSHAALCDFGHAVC 216 Query: 227 GPM---GDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNR 283 G + GT + APE + +A+ DV+S ++L +L+G Sbjct: 217 LQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPW---- 272 Query: 284 PAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMD 343 + + + + + P A A + L EP R + Sbjct: 273 -----------TQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAA 321 Query: 344 QV 345 ++ Sbjct: 322 EL 323 >3MDY-A nrPDB Length = 337 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 66/320 (20%), Positives = 126/320 (39%), Gaps = 41/320 (12%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL-NQEGFQGHREWL 119 + + + IG+G +G V+ G G +AVK E RE Sbjct: 33 RTIAKQIQMVKQIGKGRYGEVWMGKWR-----------GEKVAVKVFFTTEEASWFRE-- 79 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDE----HRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 TEI + H N++ I ++ L+ ++ + GSL ++L L Sbjct: 80 TEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLK-----STTLDAK 134 Query: 176 LRVNVALDAAKGLAFLHSD------PVKVIYRDIKASNILLDADYNAKLSDFGLARDG-- 227 + +A + GL LH++ + +RD+K+ NIL+ + ++D GLA Sbjct: 135 SMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFIS 194 Query: 228 PMGDLSYVSTRVMGTYGYAAPEYM----SSGHL--NARSDVYSFGVLLLE----ILSGKR 277 ++ +GT Y PE + + H +D+YSFG++L E +SG Sbjct: 195 DTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGI 254 Query: 278 ALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPK 337 ++ P + D + + + + + + E +M + +C + P Sbjct: 255 VEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPA 314 Query: 338 SRPTMDQVVRALQQLQDNLG 357 SR T +V + L ++ ++ Sbjct: 315 SRLTALRVKKTLAKMSESQD 334 >3KN6-A nrPDB Length = 325 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 70/312 (22%), Positives = 121/312 (38%), Gaps = 37/312 (11%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLS 129 D +GEG F K + AVK +++ + EI L Sbjct: 16 DKPLGEGSFSICRKC---------VHKKSNQAFAVKIISK---RMEANTQKEITALKLCE 63 Query: 130 -HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 HPN+VKL + H LV E + G L + ++ + + + + Sbjct: 64 GHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEA----SYIMRKLVSAV 119 Query: 189 AFLHSDPVKVIYRDIKASNILL---DADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGY 245 + +H V V++RD+K N+L + + K+ DFG AR P + + T Y Sbjct: 120 SHMH--DVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTP--CFTLHY 175 Query: 246 AAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALD-HNRPAKEENLVDWARPYLTSKRKV 304 AAPE ++ + D++S GV+L +LSG+ H+R + V+ + Sbjct: 176 AAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKG---- 231 Query: 305 LLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNP 364 D + + + + L+ +P R M +R + LQD G +NP Sbjct: 232 ----DFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSG-LRYNEWLQD--GSQLSSNP 284 Query: 365 VKDTKKLGFKTG 376 + T + +G Sbjct: 285 LM-TPDILGSSG 295 >3E7O-A nrPDB Length = 360 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 66/316 (20%), Positives = 120/316 (37%), Gaps = 53/316 (16%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTEI 122 + ++ IG G G V + G+ +AVKKL++ + + E+ Sbjct: 22 KRYQQLKPIGSGAQGIVCAAF---------DTVLGINVAVKKLSRPFQNQTHAKRAYREL 72 Query: 123 NYLGQLSHPNLVKLIGYCL------EDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 L ++H N++ L+ E + LV E M +L + L Sbjct: 73 VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIHM------ELDHER 125 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 + G+ LHS +I+RD+K SNI++ +D K+ DFGLAR +++ Sbjct: 126 MSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAS---TNFMM 180 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEEN------- 289 T + T Y APE + D++S G ++ E++ G + N Sbjct: 181 TPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLG 240 Query: 290 ---------LVDWARPYLTSKRKVLLIVDNRLDTQYL-PEEA-------VRMASVAVQCL 332 L R Y+ ++ I L ++ P E+ + + + L Sbjct: 241 TPSAEFMAALQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKML 300 Query: 333 SFEPKSRPTMDQVVRA 348 +P R ++D+ +R Sbjct: 301 VIDPDKRISVDEALRH 316 >3I6U-A nrPDB Length = 419 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 128/313 (40%), Gaps = 46/313 (14%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ--GHREW--- 118 + +G G G V + + T +A++ +++ F RE Sbjct: 134 RDEYIMSKTLGSGACGEVKLAF---------ERKTCKKVAIRIISKRKFAIGSAREADPA 184 Query: 119 ---LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 TEI L +L+HP ++K+ + + E +V E M+ G L + + K L Sbjct: 185 LNVETEIEILKKLNHPCIIKIKNFF-DAEDYYIVLELMEGGELFDKVV----GNKRLKEA 239 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLD---ADYNAKLSDFGLARDGPMGDL 232 + +LH + +I+RD+K N+LL D K++DFG ++ +G+ Sbjct: 240 TCKLYFYQMLLAVQYLHEN--GIIHRDLKPENVLLSSQEEDCLIKITDFGHSK--ILGET 295 Query: 233 SYVSTRVMGTYGYAAPEYM---SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEEN 289 S + T + GT Y APE + + N D +S GV+L LSG + Sbjct: 296 SLMRT-LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEH------- 347 Query: 290 LVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRAL 349 R ++ K ++ N + + E + + + + L +PK+R T ++ +R Sbjct: 348 -----RTQVSLKDQITSGKYNFIPEVWA-EVSEKALDLVKKLLVVDPKARFTTEEALRHP 401 Query: 350 QQLQDNLGKPSQT 362 +++ + Q Sbjct: 402 WLQDEDMKRKFQD 414 >6J6I-B nrPDB Length = 351 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 83/323 (25%), Positives = 159/323 (49%), Gaps = 24/323 (7%) Query: 49 STPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN 108 S P++SF+ ++ AT NF + + + ++G +++ + +K+ + Sbjct: 42 SIPIRSFSPEQILKATNNFDSSCFVSQDVYYKWYRGEIEDRSYM-----------IKRFS 90 Query: 109 QEGFQGHREWLTEINY-----LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENH-- 161 ++ G R + E+ +H N ++L+G CLE +LV+EF + G++ Sbjct: 91 EDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPFPVLVFEFAEHGAMNQRGG 150 Query: 162 LFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVI-YRDIKASNILLDADYNAKLSD 220 + G LPW +R+ + + A + +LH+ K+I +RD+K ++ LD ++ AKLSD Sbjct: 151 VIVNGEESL-LPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSD 209 Query: 221 FGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 + P G + V+GT+GY P Y + + +DVYSFG+ LL I++GK A+ Sbjct: 210 LSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYSFGICLLVIITGKPAIM 269 Query: 281 HNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMAS---VAVQCLSFEPK 337 + ++ R L K+ ++D RL + +++ + +A++C + Sbjct: 270 TISDGDLQGILSLVRE-LCENGKLDEVIDPRLMKDITSGQRLQVEACVVLALRCCKERDE 328 Query: 338 SRPTMDQVVRALQQLQDNLGKPS 360 RP M QV + L+Q++ +L S Sbjct: 329 DRPKMIQVAKELKQIEASLKNSS 351 >3HMP-A nrPDB Length = 342 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 64/324 (19%), Positives = 123/324 (37%), Gaps = 49/324 (15%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE--GFQGHRE 117 + + R + IG GG VF+ ++ + A+K +N E Q Sbjct: 51 ISVKGRIYSILKQIGSGGSSKVFQVLNEK----------KQIYAIKYVNLEEADNQTLDS 100 Query: 118 WLTEINYLGQLS--HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 + EI YL +L +++L Y + D++ +V E L + L ++ K + + Sbjct: 101 YRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKK----KSIDPW 155 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 R + + + + +H +++ D+K +N L+ D KL DFG+A S V Sbjct: 156 ERKSYWKNMLEAVHTIHQH--GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVV 212 Query: 236 STRVMGTYGYAAPEYMSSGHLNAR-----------SDVYSFGVLLLEILSGKRALDHNRP 284 +GT Y PE + + SDV+S G +L + GK Sbjct: 213 KDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF----- 267 Query: 285 AKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQ 344 + + K+ I+D + ++ + V CL +PK R ++ + Sbjct: 268 ----------QQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPE 317 Query: 345 VVRA-LQQLQDNLGKPSQTNPVKD 367 ++ Q+Q + ++ Sbjct: 318 LLAHPYVQIQTHPVNQMAKGTTEE 341 >4AF3-A nrPDB Length = 292 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 60/291 (20%), Positives = 106/291 (36%), Gaps = 40/291 (13%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH---RE 117 +F +G+G FG V+ + + ++A+K L + + + Sbjct: 19 HFTIDDFEIGRPLGKGKFGNVYLA---------REKKSHFIVALKVLFKSQIEKEGVEHQ 69 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 EI L HPN+++L Y + L+ E+ +G L L + + + Sbjct: 70 LRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRT---- 125 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 + + A L + H KVI+RDIK N+LL K++DFG + P S Sbjct: 126 ATIMEELADALMYCH--GKKVIHRDIKPENLLLGLKGELKIADFGWSVHAP----SLRRK 179 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY 297 + GT Y PE + N + D++ GVL E+L G + + + Sbjct: 180 TMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRI------ 233 Query: 298 LTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 ++D ++ + + L P R + QV Sbjct: 234 ------------VKVDLKFPASVPTGAQDLISKLLRHNPSERLPLAQVSAH 272 >1JNK-A nrPDB Length = 423 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 62/316 (19%), Positives = 117/316 (37%), Gaps = 53/316 (16%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTEI 122 + ++ IG G G V + +A+KKL++ + + E+ Sbjct: 62 KRYQNLKPIGSGAQGIVCAAY---------DAVLDRNVAIKKLSRPFQNQTHAKRAYREL 112 Query: 123 NYLGQLSHPNLVKLIGYCL------EDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 + ++H N++ L+ E + LV E M +L + L Sbjct: 113 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQM------ELDHER 165 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 + G+ LHS +I+RD+K SNI++ +D K+ DFGLAR S++ Sbjct: 166 MSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG---TSFMM 220 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNR------------- 283 T + T Y APE + D++S G ++ E++ K Sbjct: 221 TPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLG 280 Query: 284 ---PAKEENLVDWARPYLTSKRKVLLIVDNRL-DTQYLPEEA-------VRMASVAVQCL 332 P + L R Y+ ++ K + +L P ++ + + + L Sbjct: 281 TPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKML 340 Query: 333 SFEPKSRPTMDQVVRA 348 +P R ++D ++ Sbjct: 341 VIDPAKRISVDDALQH 356 >3UTO-A nrPDB Length = 573 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 63/286 (22%), Positives = 98/286 (34%), Gaps = 33/286 (11%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 ++ +G G FG V + T+ TG A K + EI Sbjct: 157 DHYDIHEELGTGAFGVVHR---------VTERATGNNFAAKFVMTPHESDKETVRKEIQT 207 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 + L HP LV L +D +++YEFM G L + + V Sbjct: 208 MSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADE---HNKMSEDEAVEYMRQV 264 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDAD--YNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 KGL +H + ++ D+K NI+ KL DFGL V+T GT Sbjct: 265 CKGLCHMHEN--NYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTT---GT 319 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 +AAPE + +D++S GVL +LSG Sbjct: 320 AEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGEND--------------DETL 365 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + D +D + + L +P +R T+ Q + Sbjct: 366 RNVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEH 411 >3FI2-A nrPDB Length = 353 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 62/316 (19%), Positives = 117/316 (37%), Gaps = 53/316 (16%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTEI 122 + ++ IG G G V + +A+KKL++ + + E+ Sbjct: 24 KRYQNLKPIGSGAQGIVCAAY---------DAVLDRNVAIKKLSRPFQNQTHAKRAYREL 74 Query: 123 NYLGQLSHPNLVKLIGYCL------EDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 + ++H N++ L+ E + LV E M +L + L Sbjct: 75 VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQM------ELDHER 127 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 + G+ LHS +I+RD+K SNI++ +D K+ DFGLAR S++ Sbjct: 128 MSYLLYQMLCGIKHLHS--AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG---TSFMM 182 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNR------------- 283 T + T Y APE + D++S G ++ E++ K Sbjct: 183 TPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLG 242 Query: 284 ---PAKEENLVDWARPYLTSKRKVLLIVDNRL-DTQYLPEEA-------VRMASVAVQCL 332 P + L R Y+ ++ K + +L P ++ + + + L Sbjct: 243 TPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKML 302 Query: 333 SFEPKSRPTMDQVVRA 348 +P R ++D ++ Sbjct: 303 VIDPAKRISVDDALQH 318 >3MY0-A nrPDB Length = 305 Score = 187 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 75/324 (23%), Positives = 132/324 (40%), Gaps = 53/324 (16%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG-HREWL 119 + R +G+G +G V++G G +AVK + Q RE Sbjct: 4 RTVARQVALVECVGKGRYGEVWRGLWH-----------GESVAVKIFSSRDEQSWFRE-- 50 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEH----RLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 TEI L H N++ I + + L+ + + GSL + L R+ L Sbjct: 51 TEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQ-----TLEPH 105 Query: 176 LRVNVALDAAKGLAFLH------SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPM 229 L + +A+ AA GLA LH + +RD K+ N+L+ ++ ++D GLA Sbjct: 106 LALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQ 165 Query: 230 GD--LSYVSTRVMGTYGYAAPEYMSSGHLN------ARSDVYSFGVLLLEI----LSGKR 277 G L + +GT Y APE + +D+++FG++L EI + Sbjct: 166 GSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGI 225 Query: 278 ALDHNRPAKEENLVDWARPYLTSKRKVLLI------VDNRLDTQYLPEEAVRMASVAVQC 331 D+ P + D P +KV+ + + NRL + +A + +C Sbjct: 226 VEDYRPPFYDVVPND---PSFEDMKKVVCVDQQTPTIPNRLAADPV---LSGLAQMMREC 279 Query: 332 LSFEPKSRPTMDQVVRALQQLQDN 355 P +R T ++ + LQ++ ++ Sbjct: 280 WYPNPSARLTALRIKKTLQKISNS 303 >4M7I-A nrPDB Length = 299 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 69/322 (21%), Positives = 127/322 (39%), Gaps = 60/322 (18%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINY 124 +F P +G GGFG VF+ A+K++ + RE + E+ Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCN---------YAIKRIRLPNRELAREKVMREVKA 56 Query: 125 LGQLSHPNLVKLIGYCLEDE------------HRLLVYEFMQKGSLENHLFRRGAYFKPL 172 L +L HP +V+ LE + + + +K +L++ + R + Sbjct: 57 LAKLEHPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCT-IEER 115 Query: 173 PWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGL--ARDGPMG 230 + +++ L A+ + FLHS +++RD+K SNI D K+ DFGL A D Sbjct: 116 ERSVCLHIFLQIAEAVEFLHSK--GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEE 173 Query: 231 DLSYVS--------TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHN 282 + + ++ T +GT Y +PE + + + D++S G++L E+L Sbjct: 174 EQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL--------- 224 Query: 283 RPAKEENLVDWARPYLTSKRKVLLIVDNR--LDTQYLPEEAVRMASVAVQCLSFEPKSRP 340 P+ T +V + D R ++ + LS P RP Sbjct: 225 ------------YPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERP 272 Query: 341 TMDQVVRALQQLQDNLGKPSQT 362 ++ + ++L P +T Sbjct: 273 EAINIIE--NAVFEDLDFPGKT 292 >2ZMD-A nrPDB Length = 390 Score = 187 bits (475), Expect = 7e-48, Method: Composition-based stats. Identities = 64/326 (19%), Positives = 123/326 (37%), Gaps = 49/326 (15%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE--GFQGHRE 117 + + R + IG GG VF+ ++ + A+K +N E Q Sbjct: 51 ISVKGRIYSILKQIGSGGSSKVFQVLNEK----------KQIYAIKYVNLEEADNQTLDS 100 Query: 118 WLTEINYLGQLS--HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 + EI YL +L +++L Y + D++ +V E L + L ++ K + + Sbjct: 101 YRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKK----KSIDPW 155 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 R + + + + +H +++ D+K +N L+ D KL DFG+A S V Sbjct: 156 ERKSYWKNMLEAVHTIHQH--GIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVV 212 Query: 236 STRVMGTYGYAAPEYMSSGHLNAR-----------SDVYSFGVLLLEILSGKRALDHNRP 284 +G Y PE + + SDV+S G +L + GK Sbjct: 213 KDSQVGAVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF----- 267 Query: 285 AKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQ 344 + + K+ I+D + ++ + V CL +PK R ++ + Sbjct: 268 ----------QQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPE 317 Query: 345 VVRA-LQQLQDNLGKPSQTNPVKDTK 369 ++ Q+Q + ++ K Sbjct: 318 LLAHPYVQIQTHPVNQMAKGTTEEMK 343 >5UUU-A nrPDB Length = 547 Score = 187 bits (474), Expect = 8e-48, Method: Composition-based stats. Identities = 70/288 (24%), Positives = 118/288 (40%), Gaps = 41/288 (14%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF---QGH 115 + L +F +IG GGFG V+ K TG + A+K L+++ QG Sbjct: 192 NIHLTMNDFSVHRIIGRGGFGEVYGC---------RKADTGKMYAMKCLDKKRIKMKQGE 242 Query: 116 REWLTEINYLGQL---SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPL 172 L E L + P +V + + + + M G L HL + G + + Sbjct: 243 TLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEAD 302 Query: 173 PWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDL 232 F + L GL +H+ V+YRD+K +NILLD + ++SD GLA D Sbjct: 303 MRFYAAEIIL----GLEHMHNRF--VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 356 Query: 233 SYVSTRVMGTYGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 +GT+GY APE + G ++ +D +S G +L ++L G ++ + + Sbjct: 357 HAS----VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEID 412 Query: 292 DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSR 339 ++ L + L + PE + S+ L + R Sbjct: 413 -----------RMTLTMAVELPDSFSPE----LRSLLEGLLQRDVNRR 445 >2A1A-B nrPDB Length = 284 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 72/309 (23%), Positives = 114/309 (36%), Gaps = 58/309 (18%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 +F+ +IG GGFG VFK G +K++ + R E+ L Sbjct: 12 DFKEIELIGSGGFGQVFKA---------KHRIDGKTYVIKRVKYNNEKAER----EVKAL 58 Query: 126 GQLSHPNLVKLIGYC----------------LEDEHRLLVYEFMQKGSLENHLFRRGAYF 169 +L H N+V G + + + EF KG+LE + +R Sbjct: 59 AKLDHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRG-- 116 Query: 170 KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPM 229 + L L + + KG+ ++HS K+I RD+K SNI L K+ DFGL Sbjct: 117 EKLDKVLALELFEQITKGVDYIHSK--KLINRDLKPSNIFLVDTKQVKIGDFGLVTSL-- 172 Query: 230 GDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEEN 289 TR GT Y +PE +SS D+Y+ G++L E+L + Sbjct: 173 -KNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDL 231 Query: 290 LVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRAL 349 K K + + LS +P+ RP +++R L Sbjct: 232 RDGIISDIFDKKEKT----------------------LLQKLLSKKPEDRPNTSEILRTL 269 Query: 350 QQLQDNLGK 358 + + K Sbjct: 270 TVWKKSPEK 278 >2HW6-A nrPDB Length = 307 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 64/297 (21%), Positives = 117/297 (39%), Gaps = 38/297 (12%) Query: 71 SVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLS- 129 ++GEG + V + G AVK + ++ E+ L Q Sbjct: 19 ELLGEGAYAKVQGAVSLQ---------NGKEYAVKIIEKQAGHSRSRVFREVETLYQCQG 69 Query: 130 HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 + N+++LI + +D LV+E +Q GS+ H+ ++ + + V D A L Sbjct: 70 NKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREA----SRVVRDVAAALD 125 Query: 190 FLHSDPVKVIYRDIKASNILLDADYNA---KLSDFGLARDGPMGD-----LSYVSTRVMG 241 FLH+ + +RD+K NIL ++ K+ DF L + + + T G Sbjct: 126 FLHTK--GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCG 183 Query: 242 TYGYAAPEYM-----SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 + Y APE + + + R D++S GV+L +LSG + A W R Sbjct: 184 SAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD----CGWDRG 239 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEE-----AVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + L + P++ + + + L + K R + QV++ Sbjct: 240 EVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQH 296 >1KOA-A nrPDB Length = 491 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 63/286 (22%), Positives = 98/286 (34%), Gaps = 33/286 (11%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 ++ +G G FG V + T+ TG A K + EI Sbjct: 51 DHYDIHEELGTGAFGVVHR---------VTERATGNNFAAKFVMTPHESDKETVRKEIQT 101 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 + L HP LV L +D +++YEFM G L + + V Sbjct: 102 MSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADE---HNKMSEDEAVEYMRQV 158 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDAD--YNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 KGL +H + ++ D+K NI+ KL DFGL V+T GT Sbjct: 159 CKGLCHMHEN--NYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTT---GT 213 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 +AAPE + +D++S GVL +LSG Sbjct: 214 AEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGEND--------------DETL 259 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + D +D + + L +P +R T+ Q + Sbjct: 260 RNVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEH 305 >3PVW-A nrPDB Length = 695 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 70/288 (24%), Positives = 118/288 (40%), Gaps = 41/288 (14%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF---QGH 115 + L +F +IG GGFG V+ K TG + A+K L+++ QG Sbjct: 183 NIHLTMNDFSVHRIIGRGGFGEVYGC---------RKADTGKMYAMKCLDKKRIKMKQGE 233 Query: 116 REWLTEINYLGQL---SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPL 172 L E L + P +V + + + + M G L HL + G + + Sbjct: 234 TLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEAD 293 Query: 173 PWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDL 232 F + L GL +H+ V+YRD+K +NILLD + ++SD GLA D Sbjct: 294 MRFYAAEIIL----GLEHMHNRF--VVYRDLKPANILLDEHGHVRISDLGLACDFSKKKP 347 Query: 233 SYVSTRVMGTYGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 +GT+GY APE + G ++ +D +S G +L ++L G ++ + + Sbjct: 348 HAS----VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEID 403 Query: 292 DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSR 339 ++ L + L + PE + S+ L + R Sbjct: 404 -----------RMTLTMAVELPDSFSPE----LRSLLEGLLQRDVNRR 436 >3C51-A nrPDB Length = 543 Score = 186 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 64/286 (22%), Positives = 105/286 (36%), Gaps = 30/286 (10%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ---GHREW 118 + F V+G GGFG VF + TG + A KKLN++ + G++ Sbjct: 182 MGEDWFLDFRVLGRGGFGEVFACQM---------KATGKLYACKKLNKKRLKKRKGYQGA 232 Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 + E L ++ +V L LV M G + H++ + Sbjct: 233 MVEKKILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAI 292 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR 238 GL LH +IYRD+K N+LLD D N ++SD GLA + G + Sbjct: 293 FYTAQIVSGLEHLHQR--NIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQT--KTKG 348 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 GT G+ APE + + D ++ GV L E+++ + A+ E + + Sbjct: 349 YAGTPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPFR----ARGEKVENKELKQR 404 Query: 299 TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQ 344 ++ V + L +P+ R Sbjct: 405 VLEQAVTY-------PDKFSPASKDFCEAL---LQKDPEKRLGFRD 440 >5O2B-A nrPDB Length = 285 Score = 186 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 66/291 (22%), Positives = 113/291 (38%), Gaps = 40/291 (13%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG--HREWLTEI 122 R + D +G G F V+KG E T + +A +L + + E Sbjct: 16 RFLKFDIELGRGAFKTVYKGLDTE---------TWVEVAWCELQDRKLTKAEQQRFKEEA 66 Query: 123 NYLGQLSHPNLVKLIGYCLE----DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 L L HPN+V+ + +LV E M G+L+ +L R FK + + Sbjct: 67 EMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR----FKVMKPKVLR 122 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD-YNAKLSDFGLARDGPMGDLSYVST 237 + KGL FLH+ +I+RD+K NI + + K+ D GLA + + Sbjct: 123 SWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMR----TSFAK 178 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY 297 V+GT + APE H + DVY+FG+ +LE+ + + + A + Sbjct: 179 SVIGTPEFMAPEMYEE-HYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIY-------- 229 Query: 298 LTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 RKV + + + + C+ R ++ ++ Sbjct: 230 ----RKVTSGIKP---ASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNH 273 >5AR8-A nrPDB Length = 326 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 124/301 (41%), Gaps = 30/301 (9%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL---NQEGFQGHREW 118 + + G G V + + +AVK L ++ Sbjct: 29 IPYHKLADLRYLSRGASGTVSSARHADWRV---------QVAVKHLHIHTPLLDSERKDV 79 Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 L E L + ++ ++G C E E +V E+M GSL L R+ + + W LR Sbjct: 80 LREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRK-TEYPDVAWPLRF 138 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTR 238 + + A G+ +LH+ +++ D+K NILLD +++ K++DFGL++ M S++ Sbjct: 139 RILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSK 198 Query: 239 VM---GTYGYAAPEYMSSGHLNARS---DVYSFGVLLLEILSGKRAL-DHNRPAKEENLV 291 GT Y PE G + S D+YS+ V+ E+LS K+ D P + V Sbjct: 199 SAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSV 258 Query: 292 DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 + ++ + + +R RM S+ + P RP+ + + L+ Sbjct: 259 SQGHRPVINEESLPYDIPHR----------ARMISLIESGWAQNPDERPSFLKCLIELEP 308 Query: 352 L 352 + Sbjct: 309 V 309 >4OTD-A nrPDB Length = 341 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 70/284 (24%), Positives = 112/284 (39%), Gaps = 42/284 (14%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE---W 118 L +F+ +V+G G FG V L +G + A+K L + E Sbjct: 9 LTLEDFKFLAVLGRGHFGKV---------LLSEFRPSGELFAIKALKKGDIVARDEVESL 59 Query: 119 LTEINYLGQLS---HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 + E L ++ HP LV L G EH V E+ G L H+ + +P F Sbjct: 60 MCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIF 118 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 V L GL FLH K++YRD+K N+LLD + K++DFGL ++G Sbjct: 119 YSACVVL----GLQFLHEH--KIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMG--YGDR 170 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 ++ GT + APE ++ D + GVLL E+L G+ + + + + Sbjct: 171 TSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVND- 229 Query: 296 PYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSR 339 + +Y + + + L P+ R Sbjct: 230 -----------------EVRYPRFLSAEAIGIMRRLLRRNPERR 256 >1KOB-A nrPDB Length = 387 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 62/326 (19%), Positives = 112/326 (34%), Gaps = 37/326 (11%) Query: 29 SRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLA----TRNFRPDSVIGEGGFGCVFKG 84 K + + + K + +++ + +G G FG V + Sbjct: 11 GSKVRGKYDGPKINDYDKFYEDIWKKYVPQPVEVKQGSVYDYYDILEELGSGAFGVVHRC 70 Query: 85 WLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDE 144 + TG V K +N EI+ + QL HP L+ L + Sbjct: 71 ---------VEKATGRVFVAKFINTPYPLDKYTVKNEISIMNQLHHPKLINLHDAFEDKY 121 Query: 145 HRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIK 204 +L+ EF+ G L + + + +N A +GL +H +++ DIK Sbjct: 122 EMVLILEFLSGGELFDRIAAEDY---KMSEAEVINYMRQACEGLKHMHEHS--IVHLDIK 176 Query: 205 ASNILLDADY--NAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDV 262 NI+ + + K+ DFGLA ++ V+T T +AAPE + + +D+ Sbjct: 177 PENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTA---TAEFAAPEIVDREPVGFYTDM 233 Query: 263 YSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAV 322 ++ GVL +LSG + + + D D + Sbjct: 234 WAIGVLGYVLLSGLSPFAGEDDLETL--------------QNVKRCDWEFDEDAFSSVSP 279 Query: 323 RMASVAVQCLSFEPKSRPTMDQVVRA 348 L EP+ R T+ + Sbjct: 280 EAKDFIKNLLQKEPRKRLTVHDALEH 305 >4C59-A nrPDB Length = 340 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 77/354 (21%), Positives = 135/354 (38%), Gaps = 56/354 (15%) Query: 48 SSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL 107 S F ++L R V+ EGGF V++ G+G A+K+L Sbjct: 10 SGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQ---------DVGSGREYALKRL 60 Query: 108 NQEGFQGHREWLTEINYLGQLS-HPNLVKL-----IGYCLEDE---HRLLVYEFMQKGSL 158 + +R + E+ ++ +LS HPN+V+ IG D LL+ E KG L Sbjct: 61 LSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELC-KGQL 119 Query: 159 ENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKL 218 L + + PL + + + + +H +I+RD+K N+LL KL Sbjct: 120 VEFLKKMESRG-PLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKL 178 Query: 219 SDFGLARDG-PMGDLSYVSTRVMG---------TYGYAAPEYM---SSGHLNARSDVYSF 265 DFG A D S+ + R T Y PE + S+ + + D+++ Sbjct: 179 CDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWAL 238 Query: 266 GVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMA 325 G +L + + + + N P+ DTQY Sbjct: 239 GCILYLLCFRQHPFEDGAKLRIVNGKYSIPPH---------------DTQY-----TVFH 278 Query: 326 SVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVKD--TKKLGFKTGT 377 S+ L P+ R ++ +VV LQ++ + +P+ + + G+ + T Sbjct: 279 SLIRAMLQVNPEERLSIAEVVHQLQEIAAA-RNVNPKSPITELLEQNGGYGSAT 331 >2I6L-A nrPDB Length = 320 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 121/313 (38%), Gaps = 46/313 (14%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 + +G GG G VF ++ +A+KK+ Q + L EI Sbjct: 11 SRYMDLKPLGCGGNGLVFSAVDNDCD---------KRVAIKKIVLTDPQSVKHALREIKI 61 Query: 125 LGQLSHPNLVKLI--------------GYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFK 170 + +L H N+VK+ G E +V E+M+ L N L + Sbjct: 62 IRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET-DLANVLEQ-----G 115 Query: 171 PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLD-ADYNAKLSDFGLARDGPM 229 PL +GL ++HS V++RD+K +N+ ++ D K+ DFGLAR Sbjct: 116 PLLEEHARLFMYQLLRGLKYIHS--ANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDP 173 Query: 230 GDLSY-VSTRVMGTYGYAAPEYMSS-GHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE 287 + + T Y +P + S + D+++ G + E+L+GK ++ Sbjct: 174 HYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQ 233 Query: 288 ENLVDWARPYLTSKRKVLLI------------VDNRLDTQYLPEEAVRMASVAVQCLSFE 335 L+ + P + + + L+ ++ TQ LP + Q L+F Sbjct: 234 MQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFS 293 Query: 336 PKSRPTMDQVVRA 348 P R T ++ + Sbjct: 294 PMDRLTAEEALSH 306 >4C0T-A nrPDB Length = 974 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 52/304 (17%), Positives = 113/304 (37%), Gaps = 44/304 (14%) Query: 57 FNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR 116 ++ +F+ +GEG + V + T TG AVK L++ + Sbjct: 258 MKTIRRNVTDFKFGKELGEGSYSTV---------ILATDKITGKQYAVKVLDKRHIIKEK 308 Query: 117 EWL---TEINYLGQLSHP-NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPL 172 + E + L +LS+ ++ L + + V ++ G L + R + Sbjct: 309 KVKYVNIEKHALNRLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKRYNTLNEEC 368 Query: 173 PWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGD- 231 + + ++H + VI+RD+K NILLD +++DFG AR + Sbjct: 369 TR----HFGAQILDAIKYMHDN--GVIHRDLKPENILLDDKMRIQITDFGTARLLEKKND 422 Query: 232 ------LSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPA 285 + + +GT Y +PE + + + DV++FG ++ ++++GK Sbjct: 423 ESEEYPVDVRAKSFVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEY 482 Query: 286 KEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQV 345 + + ++ + + + + L +P R T+ ++ Sbjct: 483 LTFQKITKLQFAFSAGFPTI------------------IRDLIKKILVLQPSRRATIPEI 524 Query: 346 VRAL 349 + Sbjct: 525 QKHY 528 >5O2C-A nrPDB Length = 380 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 66/291 (22%), Positives = 113/291 (38%), Gaps = 40/291 (13%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG--HREWLTEI 122 R + D +G G F V+KG E T + +A +L + + E Sbjct: 25 RFLKFDIELGRGAFKTVYKGLDTE---------TWVEVAWCELQDRKLTKAEQQRFKEEA 75 Query: 123 NYLGQLSHPNLVKLIGYCLE----DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 L L HPN+V+ + +LV E M G+L+ +L R FK + + Sbjct: 76 EMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR----FKVMKPKVLR 131 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD-YNAKLSDFGLARDGPMGDLSYVST 237 + KGL FLH+ +I+RD+K NI + + K+ D GLA + + Sbjct: 132 SWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMR----TSFAK 187 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY 297 V+GT + APE H + DVY+FG+ +LE+ + + + A + Sbjct: 188 SVIGTPEFMAPEMYEE-HYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIY-------- 238 Query: 298 LTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 RKV + + + + C+ R ++ ++ Sbjct: 239 ----RKVTSGIKP---ASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNH 282 >4KIK-B nrPDB Length = 677 Score = 184 bits (467), Expect = 5e-47, Method: Composition-based stats. Identities = 73/296 (24%), Positives = 114/296 (38%), Gaps = 40/296 (13%) Query: 68 RPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYLG 126 +G GGFG V + TG IA+K+ QE +RE W EI + Sbjct: 22 EMKERLGTGGFGNV---------IRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMR 72 Query: 127 QLSHPNLVKLIGY------CLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 +L+HPN+V ++ LL E+ Q G L +L + L + + Sbjct: 73 RLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCC-GLREGAILTL 131 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA---KLSDFGLARDGPMGDLSYVST 237 D A L +LH + ++I+RD+K NI+L K+ D G A++ G L T Sbjct: 132 LSDIASALRYLHEN--RIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLC---T 186 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRAL--------DHNRPAKEEN 289 +GT Y APE + D +SFG L E ++G R H++ ++ Sbjct: 187 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE 246 Query: 290 LVDWARPYLTSKRKVLLIVD-NRLDTQYLPEEAVRMASVAVQCLSFEPKSR---PT 341 + L K + L E + + + P+ R PT Sbjct: 247 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLML-MWH--PRQRGTDPT 299 >4PWN-A nrPDB Length = 274 Score = 184 bits (467), Expect = 6e-47, Method: Composition-based stats. Identities = 67/294 (22%), Positives = 114/294 (38%), Gaps = 35/294 (11%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL 119 + R + D IG G F V+KG E+T+ KL + Q + Sbjct: 5 MSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDR----KLTKSERQ---RFK 57 Query: 120 TEINYLGQLSHPNLVKLIGYCLE----DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 E L L HPN+V+ + +LV E M G+L+ +L R FK + Sbjct: 58 EEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKR----FKVMKIK 113 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD-YNAKLSDFGLARDGPMGDLSY 234 + + KGL FLH+ +I+RD+K NI + + K+ D GLA + + Sbjct: 114 VLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA---TLEKRAS 170 Query: 235 VSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWA 294 + V+GT + APE + DVY+FG+ +LE+ + + + A + Sbjct: 171 FAKSVIGTPEFMAPEMYEE-KYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIY----- 224 Query: 295 RPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 R+V V + + + C+ R ++ ++ Sbjct: 225 -------RRVTSGVKP---ASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNH 268 >3SOC-A nrPDB Length = 322 Score = 184 bits (467), Expect = 6e-47, Method: Composition-based stats. Identities = 72/312 (23%), Positives = 116/312 (37%), Gaps = 43/312 (13%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY-- 124 + V G FGCV+K L +AVK Q + W E Sbjct: 26 LQLLEVKARGRFGCVWKAQLLN-----------EYVAVKIF---PIQDKQSWQNEYEVYS 71 Query: 125 LGQLSHPNLVKLIGYCLE----DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 L + H N+++ IG D L+ F +KGSL + L + W ++ Sbjct: 72 LPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKAN-----VVSWNELCHI 126 Query: 181 ALDAAKGLAFLHS--------DPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDL 232 A A+GLA+LH + +RDIK+ N+LL + A ++DFGLA G Sbjct: 127 AETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKS 186 Query: 233 SYVSTRVMGTYGYAAPEYMS-----SGHLNARSDVYSFGVLLLEILSGKR----ALDHNR 283 + + +GT Y APE + R D+Y+ G++L E+ S +D Sbjct: 187 AGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYM 246 Query: 284 PAKEENLVDWARPYLTSKRKVLLIVDNRLDTQY-LPEEAVRMASVAVQCLSFEPKSRPTM 342 EE + + V L + + +C + ++R + Sbjct: 247 LPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSA 306 Query: 343 DQVVRALQQLQD 354 V + Q+Q Sbjct: 307 GCVGERITQMQR 318 >3PG1-A nrPDB Length = 362 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 71/334 (21%), Positives = 111/334 (33%), Gaps = 52/334 (15%) Query: 57 FNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH- 115 EL + I G +G V G E G+ +A+K++ G Sbjct: 14 IAELHAMQSPYTVQRFISSGSYGAVCAGVDSE----------GIPVAIKRVFNTVSDGRT 63 Query: 116 ----------REWLTEINYLGQLSHPNLVKLIGYCLEDEH-----RLLVYEFMQKGSLEN 160 + L EI L HPN++ L + E LV E M + L Sbjct: 64 VNILSDSFLCKRVLREIRLLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELM-RTDLAQ 122 Query: 161 HLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSD 220 + + P GL LH V++RD+ NILL + + + D Sbjct: 123 VIHDQRIVISP---QHIQYFMYHILLGLHVLHE--AGVVHRDLHPGNILLADNNDITICD 177 Query: 221 FGLARDGPMGDLSYVSTRVMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILSGKRAL 279 F LAR+ T + Y APE M D++S G ++ E+ + K Sbjct: 178 FNLARE---DTADANKTHYVTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALF 234 Query: 280 DH--------------NRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMA 325 P E+ ++ + R L V R T +P Sbjct: 235 RGSTFYNQLNKIVEVVGTPKIEDVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVAL 294 Query: 326 SVAVQCLSFEPKSRPTMDQVVRA--LQQLQDNLG 357 + + L F P+ R + +Q +R + L D L Sbjct: 295 DLIAKMLEFNPQRRISTEQALRHPYFESLFDPLD 328 >5AIR-A nrPDB Length = 430 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 76/364 (20%), Positives = 134/364 (36%), Gaps = 52/364 (14%) Query: 13 IFHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSV 72 + S + +S K S V T G+ S+T V Sbjct: 24 CKPVQQPSAFGSMKVSIDKDGSKVTTVVATPGQGPDRPQEVSYT------------DTKV 71 Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 IG G FG V++ L + +G ++A+KK+ Q+ +R E+ + +L H N Sbjct: 72 IGNGSFGVVYQAKLCD---------SGELVAIKKVLQDKRFKNR----ELQIMRKLDHCN 118 Query: 133 LVKLIGYCLEDEH------RLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAK 186 +V+L + LV +++ ++ + LP + Sbjct: 119 IVRLRYFFYSSGEKKDEVYLNLVLDYVP-ETVYRVARHYSRAKQTLPVIYVKLYMYQLFR 177 Query: 187 GLAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFGLARDGPMGDLSYVSTRVMGTYGY 245 LA++HS + +RDIK N+LLD D KL DFG A+ G+ + + + Y Sbjct: 178 SLAYIHS--FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN---VSYICSRYY 232 Query: 246 AAPEYMSS-GHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE--ENLVDWARPYLTSKR 302 APE + + DV+S G +L E+L G+ + + E + P R Sbjct: 233 RAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR 292 Query: 303 KVLLIVDNRLDTQ---------YLPEEAVRMASVAVQCLSFEPKSRPTMDQ--VVRALQQ 351 ++ Q + P ++ + L + P +R T + + Sbjct: 293 EMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDE 352 Query: 352 LQDN 355 L+D Sbjct: 353 LRDP 356 >3MIA-A nrPDB Length = 351 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 70/312 (22%), Positives = 111/312 (35%), Gaps = 48/312 (15%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG--HREWLTEINY 124 + + IG+G FG VFK TG +A+KK+ E + L EI Sbjct: 19 YEKLAKIGQGTFGEVFKA---------RHRKTGQKVALKKVLMENEKEGFPITALREIKI 69 Query: 125 LGQLSHPNLVKLIGYCLED--------EHRLLVYEFMQK---GSLENHLFRRGAYFKPLP 173 L L H N+V LI C LV++F + G L N L + Sbjct: 70 LQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK-------FT 122 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 V GL ++H + K+++RD+KA+N+L+ D KL+DFGLAR + S Sbjct: 123 LSEIKRVMQMLLNGLYYIHRN--KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS 180 Query: 234 Y--VSTRVMGTYGYAAPEYMS-SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENL 290 T + T Y PE + D++ G ++ E+ + + N + L Sbjct: 181 QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL 240 Query: 291 VDWARPYLTSK--------------RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEP 336 + +T + V D + + L +P Sbjct: 241 ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP 300 Query: 337 KSRPTMDQVVRA 348 R D + Sbjct: 301 AQRIDSDDALNH 312 >4O2Z-A nrPDB Length = 377 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 61/323 (18%), Positives = 111/323 (34%), Gaps = 41/323 (12%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTEINY 124 + ++G G +G TG +++KK + + L EI+ Sbjct: 47 YTLLKILGMGAYGIACSC---------LDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDM 97 Query: 125 LGQLSHPNLVK-------LIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 + H NL+ L E +V M + L R + L Sbjct: 98 MRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMD-VDMNVVLRSR----QVLEESHM 152 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 +GL +LHS V +RD+K +N++ + K+ DFGL+R + T Sbjct: 153 QYFVYQILRGLKYLHS--ANVAHRDLKPANLVTNISCELKIIDFGLSRSVDV--PYSELT 208 Query: 238 RVMGTYGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDW--- 293 + T Y PE + + + D++S G + E+ + K + ++ Sbjct: 209 DYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIG 268 Query: 294 ARPYLTSKRKVLLIVDNRLDTQ--YLPEEAVRMA------SVAVQCLSFEPKSRPTMDQV 345 P + + L N L +P+ +A + + +P RPT + Sbjct: 269 KPPASIVEHREALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADM 328 Query: 346 VRA--LQQLQDNLGKPSQTNPVK 366 + L L D +P+ P Sbjct: 329 LAHPYLAHLHDEEDEPTCPCPFL 351 >5O0Y-A nrPDB Length = 579 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 60/288 (20%), Positives = 115/288 (39%), Gaps = 45/288 (15%) Query: 78 FGCVFKGWLDESTLTPTKPGTGLVIAVKK--LNQEGFQGHRE-----WLTEINYLGQLSH 130 F V+K + +AVK LN+ +E E +L H Sbjct: 297 FSEVYKAF---------DLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDH 347 Query: 131 PNLVKLIGYC-LEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLA 189 P +VKL Y L+ + V E+ + L+ +L + K + ++ + L Sbjct: 348 PRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQH----KLMSEKEARSIIMQIVNALK 403 Query: 190 FLHSDPVKVIYRDIKASNILL---DADYNAKLSDFGLARDGPMG-----DLSYVSTRVMG 241 +L+ +I+ D+K NILL A K++DFGL++ D ++++ G Sbjct: 404 YLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAG 463 Query: 242 TYGYAAPEYM----SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY 297 TY Y PE ++ + DV+S GV+ + L G++ HN+ ++ Sbjct: 464 TYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQD---------- 513 Query: 298 LTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQV 345 + + +L + + + P + +CL++ + R + Q+ Sbjct: 514 ILQENTILKATEVQFPPK--PVVTPEAKAFIRRCLAYRKEDRIDVQQL 559 >4X7Q-B nrPDB Length = 312 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 68/325 (20%), Positives = 127/325 (39%), Gaps = 61/325 (18%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 + + +R ++G+GGFG VF G + L +A+K + + G Sbjct: 24 KDREAFEAEYRLGPLLGKGGFGTVFAG---------HRLTDRLQVAIKVIPRNRVLGWSP 74 Query: 118 WLT------EINYLGQLS----HPNLVKLIGYCLEDEHRLLVYEF-MQKGSLENHLFRRG 166 E+ L ++ HP +++L+ + E +LV E + L +++ +G Sbjct: 75 LSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKG 134 Query: 167 AYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLD-ADYNAKLSDFGLAR 225 + + HS V++RDIK NIL+D AKL DFG Sbjct: 135 PLGEGPSR----CFFGQVVAAIQHCHSR--GVVHRDIKDENILIDLRRGCAKLIDFGSGA 188 Query: 226 DGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNA-RSDVYSFGVLLLEILSGKRALDHNRP 284 T GT Y+ PE++S +A + V+S G+LL +++ G + ++ Sbjct: 189 LLHDEPY----TDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQE 244 Query: 285 AKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQ 344 E L P+ + +CL+ +P SRP++++ Sbjct: 245 ILEAEL--------------------HFPAHVSPDCCA----LIRRCLAPKPSSRPSLEE 280 Query: 345 VVRALQQLQDNLGKPSQTNPVKDTK 369 ++ L + P++ P+ +K Sbjct: 281 IL-----LDPWMQTPAEDVPLNPSK 300 >2VD5-A nrPDB Length = 412 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 59/278 (21%), Positives = 103/278 (37%), Gaps = 28/278 (10%) Query: 57 FNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR 116 E++L +F VIG G F V TG V A+K +N+ Sbjct: 53 LKEVRLQRDDFEILKVIGRGAFSEV---------AVVKMKQTGQVYAMKIMNKWDMLKRG 103 Query: 117 E---WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLP 173 E + E + L + +L ++ + LV E+ G L L + G + +P Sbjct: 104 EVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFG---ERIP 160 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLS 233 + + + +H + ++RDIK NILLD + +L+DFG D + Sbjct: 161 AEMARFYLAEIVMAIDSVH--RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR-ADGT 217 Query: 234 YVSTRVMGTYGYAAPEYMS-------SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK 286 S +GT Y +PE + +G D ++ GV E+ G+ + A+ Sbjct: 218 VRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAE 277 Query: 287 EENLVDWARPYLT---SKRKVLLIVDNRLDTQYLPEEA 321 + + +L+ V + + P E Sbjct: 278 TYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPET 315 >4M66-A nrPDB Length = 325 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 82/323 (25%), Positives = 134/323 (41%), Gaps = 47/323 (14%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTE 121 ++ + +G+GGFG VF+ +AVK +N + E Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHD---------VAVKIVNSKKISW------E 61 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRL-----LVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 + + L + N++ L+G + + LV FM+ GSL L P PW L Sbjct: 62 VKAMVNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEA----PRPWPL 117 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLAR----DGPMGDL 232 + + G+ +LHS +++RD+K SNILLD + +AKL+DFGL+ Sbjct: 118 LCRLLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGS 177 Query: 233 SYVSTRVMGTYGYAAPEYMSSGHL--NARSDVYSFGVLLLEILSGKRA--LDHNRPAKEE 288 S GT Y PE + +L + SDVYSFG+L+ +L+G+ A +D +E Sbjct: 178 GSGSRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRET 237 Query: 289 NLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEA--VRMASVAVQCLSFEPKSRPTMDQVV 346 +RP LT PE ++ + + C + ++RP+ Sbjct: 238 VCDRQSRPPLTEL------------PPGSPETPGLEKLKELMIHCWGSQSENRPSFQDCE 285 Query: 347 RALQQLQDNLGKPSQTNPVKDTK 369 ++ NL K V + K Sbjct: 286 PKTNEVY-NLVKDKVDAAVSEVK 307 >3RP9-A nrPDB Length = 458 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 70/400 (17%), Positives = 135/400 (33%), Gaps = 96/400 (24%) Query: 28 SSRKSSSTVAAAQKTEGEILSSTPVKSFTF--NELKLATRNFRPDSVIGEGGFGCVFKGW 85 ++ + S + + SS P S ++ ++ R + +IG G +G V + + Sbjct: 15 GTQHTVSGSQQEGQQRKQHHSSKPTASMPRPHSDWQIPDR-YEIRHLIGTGSYGHVCEAY 73 Query: 86 LDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTEINYLGQLSHPNLVKLIGYCLED 143 V+A+KK+ + E + L EI L +L+H ++VK++ + Sbjct: 74 ---------DKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVLDIVIPK 124 Query: 144 E-----HRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKV 198 + +V E LFR Y L + + G+ ++HS + Sbjct: 125 DVEKFDELYVVLEIADSD--FKKLFRTPVY---LTELHIKTLLYNLLVGVKYVHS--AGI 177 Query: 199 IYRDIKASNILLDADYNAKLSDFGLARDGPM-------------------------GDLS 233 ++RD+K +N L++ D + K+ DFGLAR +L Sbjct: 178 LHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLK 237 Query: 234 YVSTRVMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEILS-----------------G 275 T + T Y APE + + DV+S G + E+L+ G Sbjct: 238 RQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYHADRGPLFPG 297 Query: 276 KRALDHNRPAK---------------------------EENLVDWARPYLTSKRKVLLIV 308 + K EE++ + ++ Sbjct: 298 SSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAKRYIRIFPKR 357 Query: 309 DNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + P + + + L F P R T+++ + Sbjct: 358 EGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAH 397 >3QA8-A nrPDB Length = 676 Score = 181 bits (459), Expect = 5e-46, Method: Composition-based stats. Identities = 62/222 (27%), Positives = 95/222 (42%), Gaps = 25/222 (11%) Query: 68 RPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE-WLTEINYLG 126 +G GGFG V L TG +A+K+ QE +RE W EI + Sbjct: 17 EMKERLGTGGFGYV---------LRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMK 67 Query: 127 QLSHPNLVKLIGY------CLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 +L+HPN+V ++ LL E+ + G L +L + L + Sbjct: 68 KLNHPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCC-GLKEGPIRTL 126 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA---KLSDFGLARDGPMGDLSYVST 237 D + L +LH + ++I+RD+K NI+L K+ D G A++ G+L T Sbjct: 127 LSDISSALRYLHEN--RIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELC---T 181 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRAL 279 +GT Y APE + D +SFG L E ++G R Sbjct: 182 EFVGTLQYLAPELLEQKKYTVTVDYWSFGTLAFECITGFRPF 223 >3UIU-A nrPDB Length = 306 Score = 181 bits (459), Expect = 5e-46, Method: Composition-based stats. Identities = 71/322 (22%), Positives = 115/322 (35%), Gaps = 71/322 (22%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 +F+ +IG GGFG VFK G ++++ + R E+ L Sbjct: 13 DFKEIELIGSGGFGQVFKA---------KHRIDGKTYVIRRVKYNNEKAER----EVKAL 59 Query: 126 GQLSHPNLVKLIGYC-----------------------------LEDEHRLLVYEFMQKG 156 +L H N+V G + + + EF KG Sbjct: 60 AKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKG 119 Query: 157 SLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA 216 +LE + +R + L L + + KG+ ++HS K+I+RD+K SNI L Sbjct: 120 TLEQWIEKRRG--EKLDKVLALELFEQITKGVDYIHSK--KLIHRDLKPSNIFLVDTKQV 175 Query: 217 KLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGK 276 K+ DFGL TR GT Y +PE +SS D+Y+ G++L E+L Sbjct: 176 KIGDFGLVTSL---KNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVC 232 Query: 277 RALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEP 336 + K K + + LS +P Sbjct: 233 DTAFETSKFFTDLRDGIISDIFDKKEKT----------------------LLQKLLSKKP 270 Query: 337 KSRPTMDQVVRALQQLQDNLGK 358 + RP +++R L + + K Sbjct: 271 EDRPNTSEILRTLTVWKKSPEK 292 >5E8V-A nrPDB Length = 316 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 134/321 (41%), Gaps = 56/321 (17%) Query: 68 RPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLG- 126 D+++G+G F V+K L ++T + +AVK ++ + W TE + Sbjct: 12 ELDTLVGKGRFAEVYKAKLKQNTSEQFE-----TVAVKIF---PYEEYASWKTEKDIFSD 63 Query: 127 -QLSHPNLVKLIGYCLEDEHR----LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 L H N+++ + L+ F KG+L+ +L R + W + Sbjct: 64 INLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH-----VISWEDLRKLG 118 Query: 182 LDAAKGLAFLHSD-------PVKVIYRDIKASNILLDADYNAKLSDFGLA--RDGPMGDL 232 A+G+A LHSD + +++RD+K+SNIL+ D L DFGL+ D + Sbjct: 119 SSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVD 178 Query: 233 SYVSTRVMGTYGYAAPEYMSS-------GHLNARSDVYSFGVLLLEILSGKRALDHNRPA 285 ++ +GT Y APE ++S ++DVYS ++L E+ S A+ Sbjct: 179 DLANSGQVGTARYMAPEVLASAMNLENVESF-KQTDVYSMALVLWEMTSRCNAVGE---- 233 Query: 286 KEENLVDWARPYLTSKRK---VLLIVDNRLDTQYLPEEAV---------RMASVAVQCLS 333 + D+ P+ + R+ V + DN L PE + +C Sbjct: 234 ----VKDYEPPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWD 289 Query: 334 FEPKSRPTMDQVVRALQQLQD 354 +P++R T V +L+ Sbjct: 290 HDPEARLTAQCVAERFSELEH 310 >3GC0-A nrPDB Length = 329 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 52/307 (16%), Positives = 107/307 (34%), Gaps = 38/307 (12%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG--HREWL 119 + +R + +GEG +G V+K T +A+K++ E + + Sbjct: 31 TSIDRYRRITKLGEGTYGEVYKA---------IDTVTNETVAIKRIRLEHEEEGVPGTAI 81 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 E++ L +L H N+++L + L++E+ + L+ ++ + + + + Sbjct: 82 REVSLLKELQHRNIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKN----PDVSMRVIKS 136 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILL-----DADYNAKLSDFGLARDGPMGDLSY 234 G+ F HS + ++RD+K N+LL K+ DFGLAR + + Sbjct: 137 FLYQLINGVNFCHSR--RCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQF 194 Query: 235 VSTRVMGTYGYAAPEYMS-SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDW 293 T + T Y PE + S H + D++S + E+L + + + Sbjct: 195 --THEIITLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFE 252 Query: 294 ARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVA------------VQCLSFEPKSRPT 341 + + + V L +P R + Sbjct: 253 VLGLPDDTTWPGVTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRIS 312 Query: 342 MDQVVRA 348 + Sbjct: 313 AKNALEH 319 >6CCF-A nrPDB Length = 290 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 70/312 (22%), Positives = 120/312 (38%), Gaps = 57/312 (18%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLD------------------ESTLTPTKPGTGLVI 102 + ++ S IG+G +G V + + + P G Sbjct: 1 SMQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQA 60 Query: 103 A----VKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLE--DEHRLLVYEFMQKG 156 A K+L EI L +L H N+VKLI + +++ LV++ ++KG Sbjct: 61 AQGGPAKQLLP-----LERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKG 115 Query: 157 SLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA 216 + KP D GL +LH K+++RDIK SN+LL D + Sbjct: 116 PVMEV-----PCDKPFSEEQARLYLRDVILGLEYLHCQ--KIVHRDIKPSNLLLGDDGHV 168 Query: 217 KLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGH--LNARS-DVYSFGVLLLEIL 273 K++DFG++ D ST GT + APE +S + ++ DV++ GV L + Sbjct: 169 KIADFGVSNQFEGNDAQLSST--AGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFV 226 Query: 274 SGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLS 333 GK + L RK+ + PE + + + ++ L Sbjct: 227 YGKCPFIDD-------------FILALHRKIKNEPVVFPEE---PEISEELKDLILKMLD 270 Query: 334 FEPKSRPTMDQV 345 P++R + + Sbjct: 271 KNPETRIGVPDI 282 >4CRS-A nrPDB Length = 341 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 66/297 (22%), Positives = 112/297 (37%), Gaps = 42/297 (14%) Query: 54 SFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ 113 S + + ++FR +V+ G FG V T + A+K L + Sbjct: 1 SMSQQRFQFNLQDFRCCAVLLRGHFGKVLLAEY---------KNTNEMFAIKALKKGDIV 51 Query: 114 GHRE---WLTEINY---LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGA 167 E + E + + HP LV L EH V E+ G L H+ Sbjct: 52 ARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIH-TDV 110 Query: 168 YFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG 227 + +P F V L GL +LH K++YRD+K N+LLD + K++DFGL ++G Sbjct: 111 FSEPRAVFYAACVVL----GLQYLHEH--KIVYRDLKLDNLLLDTEGFVKIADFGLCKEG 164 Query: 228 PMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE 287 ++ GT + APE ++ D + GVL+ E+L G+ + + Sbjct: 165 MG--YGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEV 222 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQ 344 + + + +Y + S+ + L P+ R + Sbjct: 223 FDSIVND------------------EVRYPRFLSTEAISIMRRLLRRNPERRLGASE 261 >4YHJ-A nrPDB Length = 584 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 83/378 (21%), Positives = 135/378 (35%), Gaps = 63/378 (16%) Query: 12 DIFHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFT-------FNELKLAT 64 +I + + GL + S + L P + + F + K Sbjct: 120 EIPPDVVTECRLGLKEENP-SKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLE 178 Query: 65 RN------FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ---GH 115 R FR V+G+GGFG V + TG + A KKL ++ + G Sbjct: 179 RQPVTKNTFRHYRVLGKGGFGEVCACQV---------RATGKMYACKKLQKKRIKKRKGE 229 Query: 116 REWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 L E L ++ +V L + LV M G L+ H++ G Sbjct: 230 AMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPG--FDEQ 287 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYV 235 V A + GL L +++YRD+K NILLD + ++SD GLA + P G Sbjct: 288 RAVFYAAELCCGLEDL--QRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVR- 344 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 +GT GY APE +++ D + G L+ E++ G K + V W Sbjct: 345 --GRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPF-----KKYKEKVKWEE 397 Query: 296 PYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSR--------------PT 341 K ++ E+A + + L+ P R P Sbjct: 398 VDQRIKNDTEEY------SEKFSEDAKSICRML---LTKNPSKRLGCRGEGAAGVKQHPV 448 Query: 342 MDQVVRALQQLQDNLGKP 359 + ++L+ N+ +P Sbjct: 449 FKDI--NFRRLEANMLEP 464 >5Y86-A nrPDB Length = 588 Score = 179 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 64/346 (18%), Positives = 123/346 (35%), Gaps = 70/346 (20%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 + +IG+G FG V + + + +A+K + E + HR+ EI L Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLR---------QYVALKMVRNEK-RFHRQAAEEIRIL 257 Query: 126 GQLSHP------NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 L N++ ++ H + +E + S++ + + F+ L Sbjct: 258 EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELL---SIDLYELIKKNKFQGFSVQLVRK 314 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN--AKLSDFGLARDGPMGDLSYVST 237 A + L LH + K+I+ D+K NILL K+ DFG + +Y+ + Sbjct: 315 FAQSILQSLDALHKN--KIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQS 372 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE-----ENLVD 292 R Y APE + + D++SFG +L E+L+G+ + E L Sbjct: 373 RF-----YRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGM 427 Query: 293 WARPYLTSKRKVLLIVDNRLDTQYLP---------------------------------- 318 L ++ ++++ +Y Sbjct: 428 PPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTAL 487 Query: 319 --EEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQT 362 + +CL ++P +R T Q +R + ++ +P T Sbjct: 488 KGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPW-ISKSVPRPLTT 532 >1ZXE-A nrPDB Length = 303 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 60/311 (19%), Positives = 114/311 (36%), Gaps = 57/311 (18%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEIN 123 +F +V+G+G FG V K + A+KK+ + L+E+ Sbjct: 5 ASDFEEIAVLGQGAFGQVVKARNALDS---------RYYAIKKIRHTE-EKLSTILSEVM 54 Query: 124 YLGQLSHPNLVKLIGYCLEDEH-------------RLLVYEFMQKGSLENHLFRRGAYFK 170 L L+H +V+ LE + + E+ + +L + + + Sbjct: 55 LLASLNHQYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQ 114 Query: 171 PLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGP-- 228 ++ + + L+++HS +I+R++K NI +D N K+ DFGLA++ Sbjct: 115 RDEYW---RLFRQILEALSYIHSQ--GIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRS 169 Query: 229 ----------MGDLSYVSTRVMGTYGYAAPEYM-SSGHLNARSDVYSFGVLLLEILSGKR 277 + S T +GT Y A E + +GH N + D+YS G++ E++ Sbjct: 170 LDILKLDSQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY--- 226 Query: 278 ALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPK 337 L R V + D + E + + +P Sbjct: 227 PFSTGM---------ERVNILKKLRSVSIEFPPDFDDNKMKVE----KKIIRLLIDHDPN 273 Query: 338 SRPTMDQVVRA 348 RP ++ + Sbjct: 274 KRPGARTLLNS 284 >5TQX-A nrPDB Length = 655 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 71/287 (24%), Positives = 113/287 (39%), Gaps = 30/287 (10%) Query: 68 RPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE-GFQGHREWLTEINYLG 126 +G GGFG V E L IA+K E + W EI + Sbjct: 11 EMRERLGTGGFGNVCLYQHRELDLK---------IAIKSCRLELSTKNRERWCHEIQIMK 61 Query: 127 QLSHPNLVKLIGY-----CLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 +L+H N+VK L + LL E+ G L L + L +++ Sbjct: 62 KLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRK-LLNKPENCCGLKESQILSLL 120 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILL-DADYNA--KLSDFGLARDGPMGDLSYVSTR 238 D G+ +LH + K+I+RD+K NI+L D K+ D G A+D G+L T Sbjct: 121 SDIGSGIRYLHEN--KIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELC---TE 175 Query: 239 VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHN-RPAKEENLVDWARP- 296 +GT Y APE + A D +SFG ++ E ++G R H+ +P + P Sbjct: 176 FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK 235 Query: 297 --YLTSKRKVLLIVDNRLDTQY--LPEEAVRMASVAVQCLSFEPKSR 339 + + + + L M + L+++P+ R Sbjct: 236 CIFACEEMSGEVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQR 282 >5ZTN-A nrPDB Length = 429 Score = 177 bits (450), Expect = 5e-45, Method: Composition-based stats. Identities = 71/347 (20%), Positives = 122/347 (35%), Gaps = 70/347 (20%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 + VIG+G FG V K + + +A+K + E + HR+ EI L Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVH---------QHVALKMVRNEK-RFHRQAAEEIRIL 147 Query: 126 GQLSHP------NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 L N++ ++ H + +E + +L + + F+ L Sbjct: 148 EHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSM-NLYELIKKNK--FQGFSLPLVRK 204 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN--AKLSDFGLARDGPMGDLSYVST 237 A + L LH + ++I+ D+K NILL K+ DFG + +Y+ + Sbjct: 205 FAHSILQCLDALHKN--RIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQS 262 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE-----ENLVD 292 R Y APE + D++S G +L E+L+G L + E L Sbjct: 263 RF-----YRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGM 317 Query: 293 WARPYLTSKRKVLLIVDNRLDTQYL-------------------------PE-------- 319 ++ L + ++ V ++ +Y PE Sbjct: 318 PSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNAL 377 Query: 320 ---EAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTN 363 + QCL ++P R T Q +R L+ L KP Sbjct: 378 KGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPW-LRRRLPKPPTGE 423 >3BGP-A nrPDB Length = 333 Score = 177 bits (450), Expect = 5e-45, Method: Composition-based stats. Identities = 72/365 (19%), Positives = 136/365 (37%), Gaps = 65/365 (17%) Query: 32 SSSTVAAAQKTEGEILSSTPVKSF------TFNELKLATRNFRPDSVIGEGGFGCVFKGW 85 S + ++ L + P E + ++ ++G GGFG V+ G Sbjct: 17 RGSHMLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSG- 75 Query: 86 LDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT------EINYLGQLSHPN--LVKLI 137 + L +A+K + ++ E E+ L ++S +++L+ Sbjct: 76 --------IRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLL 127 Query: 138 GYCLEDEHRLLVYEFMQK-GSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPV 196 + + +L+ E + L + + RGA + L + + H+ Sbjct: 128 DWFERPDSFVLILERPEPVQDLFDFITERGALQEELARS----FFWQVLEAVRHCHN--C 181 Query: 197 KVIYRDIKASNILLDAD-YNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGH 255 V++RDIK NIL+D + KL DFG V T GT Y+ PE++ Sbjct: 182 GVLHRDIKDENILIDLNRGELKLIDFGSGALLK----DTVYTDFDGTRVYSPPEWIRYHR 237 Query: 256 LNARSD-VYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDT 314 + RS V+S G+LL +++ G +H+ + R + +++V Sbjct: 238 YHGRSAAVWSLGILLYDMVCGDIPFEHD--------EEIIRGQVFFRQRV---------- 279 Query: 315 QYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVKDTKKLGFK 374 + + CL+ P RPT +++ +QD L P +T + Sbjct: 280 ------SSECQHLIRWCLALRPSDRPTFEEIQNHPW-MQDVL-LPQETA---EIHLHSLS 328 Query: 375 TGTTK 379 G +K Sbjct: 329 PGPSK 333 >3G2F-A nrPDB Length = 336 Score = 177 bits (449), Expect = 7e-45, Method: Composition-based stats. Identities = 69/330 (20%), Positives = 123/330 (37%), Gaps = 54/330 (16%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 +E L N + +IG G +G V+KG LDE +AVK + F + Sbjct: 6 SEPSLDLDNLKLLELIGRGRYGAVYKGSLDE-----------RPVAVKVFS---FANRQN 51 Query: 118 WLTEINYLG--QLSHPNLVKLI---GYCLEDE--HRLLVYEFMQKGSLENHLFRRGAYFK 170 ++ E N + H N+ + I D LLV E+ GSL +L + Sbjct: 52 FINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS--- 108 Query: 171 PLPWFLRVNVALDAAKGLAFLHSDPVK-------VIYRDIKASNILLDADYNAKLSDFGL 223 W +A +GLA+LH++ + + +RD+ + N+L+ D +SDFGL Sbjct: 109 --DWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGL 166 Query: 224 A------RDGPMGDLSYVSTRVMGTYGYAAPEYMSS-------GHLNARSDVYSFGVLLL 270 + R G+ + +GT Y APE + + D+Y+ G++ Sbjct: 167 SMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYW 226 Query: 271 EILSGKRALD--HNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPE------EAV 322 EI L + P + + T + +L+ + ++ Sbjct: 227 EIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVR 286 Query: 323 RMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 + C + ++R T + +L Sbjct: 287 SLKETIEDCWDQDAEARLTAQCAEERMAEL 316 >3FXW-A nrPDB Length = 336 Score = 177 bits (448), Expect = 8e-45, Method: Composition-based stats. Identities = 65/313 (20%), Positives = 117/313 (37%), Gaps = 46/313 (14%) Query: 45 EILSSTPVKSFTFNELKLATRNFRPDS-VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIA 103 E+L P T +++ V+G G G V + + TG A Sbjct: 13 EVLFQGPEPKKYA-----VTDDYQLSKQVLGLGVNGKVLECF---------HRRTGQKCA 58 Query: 104 VKKLNQEGFQGHREWLTEINYLGQLSH-PNLVKLIGYCLEDEH----RLLVYEFMQKGSL 158 +K L + E+++ Q S P++V ++ H L++ E M+ G L Sbjct: 59 LKLLYDSP-----KARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGEL 113 Query: 159 ENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDA---DYN 215 + + RG + + D + FLHS + +RD+K N+L + D Sbjct: 114 FSRIQERG--DQAFTEREAAEIMRDIGTAIQFLHSH--NIAHRDVKPENLLYTSKEKDAV 169 Query: 216 AKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 KL+DFG A++ L T Y APE + + D++S GV++ +L G Sbjct: 170 LKLTDFGFAKETTQNALQ----TPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCG 225 Query: 276 KRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFE 335 N P + + ++ + + E+A ++ + L + Sbjct: 226 FPPFY-------SNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLL---LKTD 275 Query: 336 PKSRPTMDQVVRA 348 P R T+ Q + Sbjct: 276 PTERLTITQFMNH 288 >4E7W-A nrPDB Length = 394 Score = 177 bits (448), Expect = 9e-45, Method: Composition-based stats. Identities = 62/301 (20%), Positives = 115/301 (38%), Gaps = 39/301 (12%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLG 126 + VIG G FG VF+ L ES +A+KK+ Q+ +R E+ + Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESD----------EVAIKKVLQDKRFKNR----ELQIMR 87 Query: 127 QLSHPNLVKLIGYCLEDEH------RLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 + HPN+V L + + LV E++ ++ + +P L Sbjct: 88 IVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVP-ETVYRASRHYAKLKQTMPMLLIKLY 146 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDA-DYNAKLSDFGLARDGPMGDLSYVSTRV 239 + LA++HS + + +RDIK N+LLD KL DFG A+ G+ + Sbjct: 147 MYQLLRSLAYIHS--IGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPN---VSY 201 Query: 240 MGTYGYAAPEYMSS-GHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYL 298 + + Y APE + + D++S G ++ E++ G+ + + Sbjct: 202 ICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTP 261 Query: 299 TSKR-----------KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 + ++ K I + + P + + L + P +R T + + Sbjct: 262 SREQIKTMNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALC 321 Query: 348 A 348 Sbjct: 322 H 322 >2Y4I-B nrPDB Length = 319 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 54/315 (17%), Positives = 116/315 (36%), Gaps = 48/315 (15%) Query: 52 VKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLN--Q 109 S E + +IG+G FG V+ G +A++ ++ + Sbjct: 20 QTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHG------------EVAIRLIDIER 67 Query: 110 EGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF 169 + + + E+ Q H N+V +G C+ H ++ + +L + + Sbjct: 68 DNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKI-- 125 Query: 170 KPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGL---ARD 226 L +A + KG+ +LH+ ++++D+K+ N+ D + ++DFGL + Sbjct: 126 -VLDVNKTRQIAQEIVKGMGYLHAK--GILHKDLKSKNVFYD-NGKVVITDFGLFSISGV 181 Query: 227 GPMGDLSYVSTRVMGTYGYAAPEYMSS---------GHLNARSDVYSFGVLLLEILSGKR 277 G G + APE + + SDV++ G + E+ + + Sbjct: 182 LQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREW 241 Query: 278 ALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPK 337 K + T + L + ++ + + C +FE + Sbjct: 242 PF------KTQPAEAIIWQMGTGMKPNLSQIGMG----------KEISDILLFCWAFEQE 285 Query: 338 SRPTMDQVVRALQQL 352 RPT +++ L++L Sbjct: 286 ERPTFTKLMDMLEKL 300 >3ORP-A nrPDB Length = 311 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 66/284 (23%), Positives = 114/284 (40%), Gaps = 37/284 (13%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR---EWLT 120 + + ++G GG V +AVK L + + + Sbjct: 11 SDRYELGEILGFGGMSEVHLARDLRDHRD---------VAVKVLRADLARDPSFYLRFRR 61 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEH----RLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 E L+HP +V + + +V E++ +L + + G P+ Sbjct: 62 EAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEG----PMTPKR 117 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD-GPMGDLSYV 235 + V DA + L F H + +I+RD+K +NI++ A K+ DFG+AR G+ Sbjct: 118 AIEVIADACQALNFSHQN--GIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQ 175 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 + V+GT Y +PE ++ARSDVYS G +L E+L+G+ + P Sbjct: 176 TAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVRED 235 Query: 296 PYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSR 339 P S R L D + +V ++ L+ P++R Sbjct: 236 PIPPSARHEGLSAD--------------LDAVVLKALAKNPENR 265 >4RC3-A nrPDB Length = 289 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 69/334 (20%), Positives = 129/334 (38%), Gaps = 59/334 (17%) Query: 57 FNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR 116 E + ++ ++G GGFG V+ G + L +A+K + ++ Sbjct: 4 MKEKEPLESQYQVGPLLGSGGFGSVYSG---------IRVSDNLPVAIKHVEKDRISDWG 54 Query: 117 EWLT------EINYLGQLSHPN--LVKLIGYCLEDEHRLLVYEFMQK-GSLENHLFRRGA 167 E E+ L ++S +++L+ + + +L+ E + L + + RGA Sbjct: 55 ELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA 114 Query: 168 YFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD-YNAKLSDFGLARD 226 + L + + H+ V++RDIK NIL+D + KL DFG Sbjct: 115 LQEELARS----FFWQVLEAVRHCHN--CGVLHRDIKDENILIDLNRGELKLIDFGSGAL 168 Query: 227 GPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSD-VYSFGVLLLEILSGKRALDHNRPA 285 V T GT Y+ PE++ + RS V+S G+LL +++ G +H+ Sbjct: 169 LK----DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD--- 221 Query: 286 KEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQV 345 + R + +++V + + CL+ P RPT +++ Sbjct: 222 -----EEIIRGQVFFRQRV----------------SSECQHLIRWCLALRPSDRPTFEEI 260 Query: 346 VRALQQLQDNLGKPSQTNPVKDTKKLGFKTGTTK 379 +QD L P +T + G +K Sbjct: 261 QNHPW-MQDVL-LPQETA---EIHLHSLSPGPSK 289 >3REP-A nrPDB Length = 271 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 63/282 (22%), Positives = 116/282 (41%), Gaps = 39/282 (13%) Query: 79 GCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIG 138 G ++KG G +V+ V K+ + R++ E L SHPN++ ++G Sbjct: 24 GELWKGRW---------QGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLG 74 Query: 139 YCLEDE--HRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPV 196 C H L+ +M GSL N L + V ALD A+G+AFLH+ Sbjct: 75 ACQSPPAPHPTLITHWMPYGSLYNVL--HEGTNFVVDQSQAVKFALDMARGMAFLHTLEP 132 Query: 197 KVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHL 256 + + + ++++D D A++S S+ S M + APE + Sbjct: 133 LIPRHALNSRSVMIDEDMTARIS-------MADVKFSFQSPGRMYAPAWVAPEALQKKPE 185 Query: 257 NA---RSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLD 313 + +D++SF VLL E+++ + L++ + + L Sbjct: 186 DTNRRSADMWSFAVLLWELVTREVPFAD----------------LSNMEIGMKVALEGLR 229 Query: 314 TQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 P + ++ + C++ +P RP D +V L+++QD Sbjct: 230 PTIPPGISPHVSKLMKICMNEDPAKRPKFDMIVPILEKMQDK 271 >3N9X-A nrPDB Length = 432 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 70/371 (18%), Positives = 124/371 (33%), Gaps = 87/371 (23%) Query: 49 STPVKSFTFNELKLA--TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKK 106 S+ ++ F +K N+ +IG G +G V+ + T +A+KK Sbjct: 8 SSGRENLYFQGIKNVHVPDNYIIKHLIGRGSYGYVYLAY---------DKNTEKNVAIKK 58 Query: 107 LNQ--EGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDE-----HRLLVYEFMQKGSLE 159 +N+ E + L EI L +L +++L + D+ +V E Sbjct: 59 VNRMFEDLIDCKRILREITILNRLKSDYIIRLYDLIIPDDLLKFDELYIVLEIADSD--L 116 Query: 160 NHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLS 219 LF+ + L + + G F+H +I+RD+K +N LL+ D + K+ Sbjct: 117 KKLFKTPIF---LTEEHIKTILYNLLLGENFIHES--GIIHRDLKPANCLLNQDCSVKVC 171 Query: 220 DFGLARDGPMGDLS--------------------YVSTRVMGTYGYAAPE-YMSSGHLNA 258 DFGLAR + T + T Y APE + + Sbjct: 172 DFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTK 231 Query: 259 RSDVYSFGVLLLEILS-----------------GKRALDHNRPAK--------------- 286 D++S G + E+L+ G + Sbjct: 232 SIDIWSTGCIFAELLNMLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNI 291 Query: 287 ---------EENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPK 337 E++L + +P + K+ Q P + ++ L F P Sbjct: 292 IFNIIGTPTEDDLKNINKPEVIKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPN 351 Query: 338 SRPTMDQVVRA 348 R T+DQ + Sbjct: 352 KRITIDQALDH 362 >3E3P-A nrPDB Length = 360 Score = 175 bits (444), Expect = 2e-44, Method: Composition-based stats. Identities = 72/356 (20%), Positives = 130/356 (36%), Gaps = 46/356 (12%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 + F+ + + G+G FG V G + TG+ +A+KK+ Q+ +RE L Sbjct: 19 RKEMDRFQVERMAGQGTFGTVQLG---------KEKSTGMSVAIKKVIQDPRFRNRE-LQ 68 Query: 121 EINYLGQLSHPNLVKLIGYCL-----EDEHRLL--VYEFMQKGSLENHLFRRGAYFKPLP 173 + L L HPN+V+L Y + L V E++ +L P Sbjct: 69 IMQDLAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVP-DTLHRCCRNYYRRQVAPP 127 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDA-DYNAKLSDFGLARDGPMGDL 232 L + + LH V V +RDIK N+L++ D KL DFG A+ + Sbjct: 128 PILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEP 187 Query: 233 SYVSTRVMGTYGYAAPEYMS-SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE--EN 289 + + + Y APE + + H D++S G + E++ G+ + A + E Sbjct: 188 N---VAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEI 244 Query: 290 LVDWARPYLTSKRKVLL------------IVDNRLDTQYLPEEAVRMASVAVQCLSFEPK 337 + P RK+ I + + + + ++A + L + P+ Sbjct: 245 VRVLGCPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPE 304 Query: 338 SR---------PTMDQVVRALQQLQDNLGKPSQTNPVKDTKKLGFKTGTTKSSEKR 384 R P D++ +L +N P + ++ Sbjct: 305 ERMKPYEALCHPYFDELHDPATKLPNNKDLPEDLFRFLPNEIEVMSEAQKAKLVRK 360 >5TUR-A nrPDB Length = 404 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 69/333 (20%), Positives = 129/333 (38%), Gaps = 59/333 (17%) Query: 58 NELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 E + ++ ++G GGFG V+ G + L +A+K + ++ E Sbjct: 120 KEKEPLESQYQVGPLLGSGGFGSVYSG---------IRVSDNLPVAIKHVEKDRISDWGE 170 Query: 118 WLT------EINYLGQLSHPN--LVKLIGYCLEDEHRLLVYEFMQK-GSLENHLFRRGAY 168 E+ L ++S +++L+ + + +L+ E + L + + RGA Sbjct: 171 LPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGAL 230 Query: 169 FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD-YNAKLSDFGLARDG 227 + L + + H+ V++RDIK NIL+D + KL DFG Sbjct: 231 QEELARS----FFWQVLEAVRHCHN--CGVLHRDIKDENILIDLNRGELKLIDFGSGALL 284 Query: 228 PMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSD-VYSFGVLLLEILSGKRALDHNRPAK 286 V T GT Y+ PE++ + RS V+S G+LL +++ G +H+ Sbjct: 285 K----DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD---- 336 Query: 287 EENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVV 346 + R + +++V + + CL+ P RPT +++ Sbjct: 337 ----EEIIRGQVFFRQRV----------------SSECQHLIRWCLALRPSDRPTFEEIQ 376 Query: 347 RALQQLQDNLGKPSQTNPVKDTKKLGFKTGTTK 379 +QD L P +T + G +K Sbjct: 377 NHPW-MQDVL-LPQETA---EIHLHSLSPGPSK 404 >6EAS-A nrPDB Length = 308 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 77/306 (25%), Positives = 138/306 (45%), Gaps = 32/306 (10%) Query: 50 TPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ 109 T V S +EL+ A +F ++IG ++KG L S+ + LV + K ++ Sbjct: 27 TGVPSLKRSELETACEDFS--NIIGSTSTCMLYKGTL--SSGVEIAVASSLVTSAKDWSK 82 Query: 110 EGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEH--RLLVYEFMQKGSLENHLFRRGA 167 E +R+ +T L ++SH N + L+GYC E+ R++V+E+ G+L HL R A Sbjct: 83 ENESQYRKKIT---NLSKVSHKNFMNLLGYCEEEHPFTRVMVFEYAPNGTLFEHLHVREA 139 Query: 168 YFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG 227 + L W R+ +++ A L +H R+ ++ + L D+ AK+SD D Sbjct: 140 --EKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDLEFWNDA 197 Query: 228 PMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE 287 G E S + V +G++LLEIL+G+ + + Sbjct: 198 ------------KGHNSTTNNELAFSPDM--EDIVRKYGMVLLEILTGRVPSSED----D 239 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVR-MASVAVQCLSFEPKSRPTMDQVV 346 L +W Y ++ ++D + + PE+ R + V C+ +PK RP M +V Sbjct: 240 GPLENWVSRYFEGGMRLEELIDPSIG--FFPEDTARALCEVVRSCIDRDPKKRPQMKEVA 297 Query: 347 RALQQL 352 ++++ Sbjct: 298 ARMREI 303 >5B2L-A nrPDB Length = 324 Score = 174 bits (441), Expect = 5e-44, Method: Composition-based stats. Identities = 70/291 (24%), Positives = 119/291 (40%), Gaps = 38/291 (13%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEG-FQGHREWLTEIN 123 + +G G G V+K + TG VIAVK++ + G + ++ L +++ Sbjct: 17 NDLENLGEMGSGTCGQVWKMRFRK---------TGHVIAVKQMRRSGNKEENKRILMDLD 67 Query: 124 Y-LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 L P +V+ G + + + E M G+ L +R P+P + + + Sbjct: 68 VVLKSHDCPYIVQCFGTFITNTDVFIAMELM--GTSAEKLKKRMQG--PIPERILGKMTV 123 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 K L +L + VI+RD+K SNILLD KL DFG++ S TR G Sbjct: 124 AIVKALYYL-KEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVD---SKAKTRSAGC 179 Query: 243 YGYAAPEYMS-----SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY 297 Y APE + + R+DV+S G+ L+E+ +G+ + + E Sbjct: 180 AAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLT------- 232 Query: 298 LTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 KVL L + S CL+ + + RP ++++ Sbjct: 233 -----KVLQEEPPLLPGHM--GFSGDFQSFVKDCLTKDHRKRPKYNKLLEH 276 >3HKO-A nrPDB Length = 345 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 58/280 (20%), Positives = 96/280 (34%), Gaps = 58/280 (20%) Query: 54 SFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQ 113 F L + + IG+G +G V + T + A+K +N+ + Sbjct: 15 YFQGGSLLELQKKYHLKGAIGQGSYGVV---------RVAIENQTRAIRAIKIMNKNKIR 65 Query: 114 -----GHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFR---- 164 TE+ + +L HPN+ +L ++++ LV E G L + L Sbjct: 66 QINPKDVERIKTEVRLMKKLHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDD 125 Query: 165 --------------------------------RGAYFKPLPWFLRVNVALDAAKGLAFLH 192 R + L N+ L +LH Sbjct: 126 STGKCAMDVVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLH 185 Query: 193 SDPVKVIYRDIKASNILLDAD--YNAKLSDFGLARDGPM--GDLSYVSTRVMGTYGYAAP 248 + + +RDIK N L + + KL DFGL+++ Y T GT + AP Sbjct: 186 NQ--GICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAP 243 Query: 249 EYMS--SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK 286 E ++ + + D +S GVLL +L G A Sbjct: 244 EVLNTTNESYGPKCDAWSAGVLLHLLLMGAVPFPGVNDAD 283 >2QLU-A nrPDB Length = 314 Score = 174 bits (440), Expect = 8e-44, Method: Composition-based stats. Identities = 67/319 (21%), Positives = 121/319 (37%), Gaps = 44/319 (13%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTE 121 + + + + G FGCV+K L +AVK Q + W +E Sbjct: 12 VPRGSLQLLEIKARGRFGCVWKAQLMND-----------FVAVKIF---PLQDKQSWQSE 57 Query: 122 INYLGQ--LSHPNLVKLIGYCLE----DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWF 175 + H NL++ I + L+ F KGSL ++L + W Sbjct: 58 REIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLK-----GNIITWN 112 Query: 176 LRVNVALDAAKGLAFLHS---------DPVKVIYRDIKASNILLDADYNAKLSDFGLARD 226 +VA ++GL++LH + +RD K+ N+LL +D A L+DFGLA Sbjct: 113 ELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVR 172 Query: 227 GPMGDLSYVSTRVMGTYGYAAPEYMS-----SGHLNARSDVYSFGVLLLEILSGKR---- 277 G + +GT Y APE + R D+Y+ G++L E++S + Sbjct: 173 FEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADG 232 Query: 278 ALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYL-PEEAVRMASVAVQCLSFEP 336 +D EE + + V + + +L ++ +C + Sbjct: 233 PVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDA 292 Query: 337 KSRPTMDQVVRALQQLQDN 355 ++R + V + ++ + Sbjct: 293 EARLSAGCVEERVSLIRRS 311 >6CKI-A nrPDB Length = 316 Score = 173 bits (439), Expect = 9e-44, Method: Composition-based stats. Identities = 71/295 (24%), Positives = 117/295 (39%), Gaps = 32/295 (10%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLS 129 + V+GEG V T T AVK + ++ E+ L Q Sbjct: 18 EDVLGEGAHARV---------QTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQ 68 Query: 130 -HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 H N+++LI + E++ LV+E M+ GS+ +H+ +R + + V D A L Sbjct: 69 GHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNE----LEASVVVQDVASAL 124 Query: 189 AFLHSDPVKVIYRDIKASNILLDADYN---AKLSDFGLARDGPM-GDLSYVSTRV----M 240 FLH+ + +RD+K NIL + K+ DFGL + GD S +ST Sbjct: 125 DFLHNK--GIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPC 182 Query: 241 GTYGYAAPEYM-----SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 G+ Y APE + + + R D++S GV+L +LSG + A Sbjct: 183 GSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEAC 242 Query: 296 PYLTSK--RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 P + + D + + + L + K R + QV++ Sbjct: 243 PACQNMLFESIQEGKYEFPDKDWAHISCA-AKDLISKLLVRDAKQRLSAAQVLQH 296 >5USZ-A nrPDB Length = 289 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 74/301 (24%), Positives = 127/301 (42%), Gaps = 40/301 (13%) Query: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT 120 K+ + + +G+G F +FKG E T + +K L++ + Sbjct: 4 KIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHET--EVLLKVLDKAHRNYSESFFE 61 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 + + +LSH +LV G C+ + +LV EF++ GSL+ +L + L ++ V Sbjct: 62 AASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINIL---WKLEV 118 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN--------AKLSDFGLARDGPMGDL 232 A A + FL + +I+ ++ A NILL + + KLSD G++ D+ Sbjct: 119 AKQLAAAMHFLEENT--LIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDI 176 Query: 233 SYVSTRVMGTYGYAAPEYMSS-GHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 + PE + + +LN +D +SFG L EI SG Sbjct: 177 LQER------IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGG--------------- 215 Query: 292 DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 D L S+RK+ D Q +A +A++ C+ +EP RP+ ++R L Sbjct: 216 DKPLSALDSQRKLQFYEDRH---QLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNS 272 Query: 352 L 352 L Sbjct: 273 L 273 >4MWI-A nrPDB Length = 294 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 58/265 (21%), Positives = 110/265 (41%), Gaps = 34/265 (12%) Query: 102 IAVKKLNQ----EGFQGHREWLTEINYLGQLSHPNLVKLIGYCLED----EHRLLVYEFM 153 +A+K + + + EI + + PN++++ G C+++ +V E+ Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYC 109 Query: 154 QKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD 213 + G+L L R K L R+ + L AA+GL LH ++ I++SN L+ Sbjct: 110 ELGTLRELLDRE----KDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQG 165 Query: 214 YNAKLSDFGLARD---GPMGDLSYVSTRVMGTYGYAAPEYMSS--GHLNARSDVYSFGVL 268 Y KL+ F L + +G + RV T Y +P+ + + +S++YSFG++ Sbjct: 166 YQVKLAGFELRKTQTSMSLGTTREKTDRVKST-AYLSPQELEDVFYQYDVKSEIYSFGIV 224 Query: 269 LLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVA 328 L EI +G K LV R + + + Sbjct: 225 LWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGE----------------DCPSELREII 268 Query: 329 VQCLSFEPKSRPTMDQVVRALQQLQ 353 +C + +P RP++D++++ L Sbjct: 269 DECRAHDPSVRPSVDEILKKLSTFS 293 >1NY3-A nrPDB Length = 400 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 56/314 (17%), Positives = 109/314 (34%), Gaps = 43/314 (13%) Query: 65 RNFRP-DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEIN 123 +++ V+G G G V L T A+K L Q + E+ Sbjct: 61 DDYKVTSQVLGLGINGKV---------LQIFNKRTQEKFALKML-----QDCPKARREVE 106 Query: 124 YL-GQLSHPNLVKLIGYCLE----DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 P++V+++ + L+V E + G L + + RG + Sbjct: 107 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRG--DQAFTEREAS 164 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLARDGPMGDLSYV 235 + + + +LHS + + +RD+K N+L + + KL+DFG A++ + Sbjct: 165 EIMKSIGEAIQYLHS--INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--- 219 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 T T Y APE + + D++S GV++ +L G N Sbjct: 220 LTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP------ 273 Query: 296 PYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 + + + E + + + L EP R T+ + + +Q Sbjct: 274 ----GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ-- 327 Query: 356 LGKPSQTNPVKDTK 369 P+ ++ Sbjct: 328 -STKVPQTPLHTSR 340 >3KA0-A nrPDB Length = 320 Score = 171 bits (433), Expect = 5e-43, Method: Composition-based stats. Identities = 56/314 (17%), Positives = 109/314 (34%), Gaps = 43/314 (13%) Query: 65 RNFRP-DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEIN 123 +++ V+G G G V L T A+K L Q + E+ Sbjct: 15 DDYKVTSQVLGLGINGKV---------LQIFNKRTQEKFALKML-----QDCPKARREVE 60 Query: 124 YL-GQLSHPNLVKLIGYCLE----DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 P++V+++ + L+V E + G L + + RG + Sbjct: 61 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRG--DQAFTEREAS 118 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLARDGPMGDLSYV 235 + + + +LHS + + +RD+K N+L + + KL+DFG A++ + Sbjct: 119 EIMKSIGEAIQYLHS--INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--- 173 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 T T Y APE + + D++S GV++ +L G N Sbjct: 174 LTEPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP------ 227 Query: 296 PYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 + + + E + + + L EP R T+ + + +Q Sbjct: 228 ----GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ-- 281 Query: 356 LGKPSQTNPVKDTK 369 P+ ++ Sbjct: 282 -STKVPQTPLHTSR 294 >4L00-A nrPDB Length = 304 Score = 171 bits (432), Expect = 6e-43, Method: Composition-based stats. Identities = 63/315 (20%), Positives = 127/315 (40%), Gaps = 40/315 (12%) Query: 50 TPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWL-DESTLTPTKPGTGLVIAVKKLN 108 P+ +F+ ++ ++ +G G ++ G L D T + + +K L+ Sbjct: 12 YPMSQLSFD--RILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLD 69 Query: 109 QEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAY 168 + + + Q+SH ++V L G C+ D ++V EF++ G L+ + R+ Sbjct: 70 PSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRK--- 126 Query: 169 FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN-------AKLSDF 221 L + VA A L++L +++ ++ N+LL + KLSD Sbjct: 127 SDVLTTPWKFKVAKQLASALSYLEDKD--LVHGNVCTKNLLLAREGIDSECGPFIKLSDP 184 Query: 222 GLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGH-LNARSDVYSFGVLLLEILSGKRALD 280 G+ + + APE + L+ +D +SFG L EI + Sbjct: 185 GI------PITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEI-----CYN 233 Query: 281 HNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP 340 P K++ L++ R Y + R V +A + +C++++P RP Sbjct: 234 GEIPLKDKTLIEKERFYESRCRPVT-------------PSCKELADLMTRCMNYDPNQRP 280 Query: 341 TMDQVVRALQQLQDN 355 ++R + +L++ Sbjct: 281 FFRAIMRDINKLEEQ 295 >2OZA-A nrPDB Length = 356 Score = 171 bits (432), Expect = 6e-43, Method: Composition-based stats. Identities = 56/314 (17%), Positives = 109/314 (34%), Gaps = 43/314 (13%) Query: 65 RNFRP-DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEIN 123 +++ V+G G G V L T A+K L Q + E+ Sbjct: 17 DDYKVTSQVLGLGINGKV---------LQIFNKRTQEKFALKML-----QDCPKARREVE 62 Query: 124 YL-GQLSHPNLVKLIGYCLE----DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 P++V+++ + L+V E + G L + + RG + Sbjct: 63 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRG--DQAFTEREAS 120 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLARDGPMGDLSYV 235 + + + +LHS + + +RD+K N+L + + KL+DFG A++ + Sbjct: 121 EIMKSIGEAIQYLHS--INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--- 175 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 T T Y APE + + D++S GV++ +L G N Sbjct: 176 LTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP------ 229 Query: 296 PYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 + + + E + + + L EP R T+ + + +Q Sbjct: 230 ----GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ-- 283 Query: 356 LGKPSQTNPVKDTK 369 P+ ++ Sbjct: 284 -STKVPQTPLHTSR 296 >4G3E-A nrPDB Length = 352 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 77/325 (23%), Positives = 126/325 (38%), Gaps = 46/325 (14%) Query: 37 AAAQKTEGEILSST--PVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPT 94 + EG +L+ PV E+ T R +G G FG V + Sbjct: 48 PETEDNEGVLLTEKLKPVDYEYREEVHWMTHQPR----VGRGSFGEVHR---------MK 94 Query: 95 KPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQ 154 TG AVKK+ E F+ + E+ LS P +V L G E + E ++ Sbjct: 95 DKQTGFQCAVKKVRLEVFR-----VEELVACAGLSSPRIVPLYGAVREGPWVNIFMELLE 149 Query: 155 KGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY 214 GSL + + G LP + A +GL +LH+ ++++ D+KA N+LL +D Sbjct: 150 GGSLGQLIKQMGC----LPEDRALYYLGQALEGLEYLHTR--RILHGDVKADNVLLSSDG 203 Query: 215 -NAKLSDFGLARDGPM---GDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLL 270 A L DFG A G + GT + APE + +A+ D++S ++L Sbjct: 204 SRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMML 263 Query: 271 EILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQ 330 +L+G Y + + + + P A A + Sbjct: 264 HMLNGCHPW---------------TQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQE 308 Query: 331 CLSFEPKSRPTMDQVVRAL-QQLQD 354 L EP R + ++ R + + LQ+ Sbjct: 309 GLRKEPVHRASAMELRRKVGKALQE 333 >4Y83-A nrPDB Length = 332 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 73/289 (25%), Positives = 109/289 (37%), Gaps = 35/289 (12%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL 119 KL RN D I G FG V+ T +A K + + F+ Sbjct: 69 WKLTYRNIGSD-FIPRGAFGKVYLAQ---------DIKTKKRMACKLIPVDQFKPSD--- 115 Query: 120 TEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 + H N+ +L G L E L E + GS+ L G P+ F + Sbjct: 116 --VEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCG----PMREFEIIW 169 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV 239 V KGL FLHS KVI+ DIK SNI+ + L DFGL+ M + Y + Sbjct: 170 VTKHVLKGLDFLHSK--KVIHHDIKPSNIVFMSTKAV-LVDFGLS--VQMTEDVYFPKDL 224 Query: 240 MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLT 299 GT Y +PE + + ++D+YS G L+ + +G P YL Sbjct: 225 RGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSA------YPSYLY 278 Query: 300 SKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 K +++ D + + M + L P RP +++ Sbjct: 279 IIHKQAPPLEDIAD-----DCSPGMRELIEASLERNPNHRPRAADLLKH 322 >4BTF-A nrPDB Length = 469 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 58/270 (21%), Positives = 119/270 (44%), Gaps = 34/270 (12%) Query: 102 IAVKKLNQEGFQG----HREWLTEINYLGQLSHPNLVKLIGYCLE----DEHRLLVYEFM 153 + +K N + + EI + + PN++++ G C++ +V E+ Sbjct: 221 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYC 280 Query: 154 QKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD 213 + G+L L R K L +R + L AA+GL LH ++R+I +S+ L+ Sbjct: 281 ELGTLRELLDRE----KDLTMSVRSLLVLRAARGLYRLHHSET--LHRNISSSSFLVAGG 334 Query: 214 YNAKLSDFGLARDGPMGDLSYVSTRVMGTYG--YAAPEYMSSGH--LNARSDVYSFGVLL 269 Y KL+ F L++ + ST+ + Y +PE + + + ++++YSFG++L Sbjct: 335 YQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVL 394 Query: 270 LEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAV 329 EI +GK + SK+ L+ +++ + + + Sbjct: 395 WEIATGKIPFEGC----------------DSKKIRELVAEDKKQEPVGQDCPELLREIIN 438 Query: 330 QCLSFEPKSRPTMDQVVRALQQLQDNLGKP 359 +C + EP RP++D ++ L ++++ K Sbjct: 439 ECRAHEPSQRPSVDGILERLSAVEESTDKK 468 Score = 30.4 bits (67), Expect = 1.5, Method: Composition-based stats. Identities = 16/62 (25%), Positives = 23/62 (37%), Gaps = 3/62 (4%) Query: 76 GGFGCVFKGWLDESTLTPTKPGTGLVIAV---KKLNQEGFQGHREWLTEINYLGQLSHPN 132 G F V K + K ++V K L E + R+ E+ L Q+ H N Sbjct: 67 GRFDEVLKEANQQIEKFSKKSHIWKFVSVGNDKILFHEVNEKLRDVWEELLLLLQVYHWN 126 Query: 133 LV 134 V Sbjct: 127 TV 128 >3NIE-A nrPDB Length = 429 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 64/381 (16%), Positives = 122/381 (32%), Gaps = 91/381 (23%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTEI 122 N+ +IG G +G V+ + +A+KK+N+ E + L EI Sbjct: 28 DNYEIKHLIGRGSYGYVYLAY---------DKNANKNVAIKKVNRMFEDLIDCKRILREI 78 Query: 123 NYLGQLSHPNLVKLIGYCLEDE-----HRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 L +L +++L + ++ +V E LF+ + L Sbjct: 79 TILNRLKSDYIIRLHDLIIPEDLLKFDELYIVLEIADSD--LKKLFKTPIF---LTEQHV 133 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMG------- 230 + + G F+H +I+RD+K +N LL+ D + K+ DFGLAR Sbjct: 134 KTILYNLLLGEKFIHES--GIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVN 191 Query: 231 ----------------DLSYVSTRVMGTYGYAAPE-YMSSGHLNARSDVYSFGVLLLEIL 273 +L T + T Y APE + + D++S G + E+L Sbjct: 192 DLEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELL 251 Query: 274 ----------SGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVR 323 + + L + ++ + L + + E+ Sbjct: 252 NMMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKC 311 Query: 324 M-------------------------------ASVAVQCLSFEPKSRPTMDQVVRA--LQ 350 + + L F + R T+D+ + L+ Sbjct: 312 ITKQEVIKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLK 371 Query: 351 QLQ-DNLGKPSQTNPVKDTKK 370 ++ +NL S + Sbjct: 372 DVRKENLENFSTEKIILPFDD 392 >4M69-B nrPDB Length = 283 Score = 168 bits (425), Expect = 4e-42, Method: Composition-based stats. Identities = 58/270 (21%), Positives = 119/270 (44%), Gaps = 34/270 (12%) Query: 102 IAVKKLNQEGFQG----HREWLTEINYLGQLSHPNLVKLIGYCLE----DEHRLLVYEFM 153 + +K N + + EI + + PN++++ G C++ +V E+ Sbjct: 35 VTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYC 94 Query: 154 QKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD 213 + G+L L R K L +R + L AA+GL LH ++R+I +S+ L+ Sbjct: 95 ELGTLRELLDRE----KDLTMSVRSLLVLRAARGLYRLHHSET--LHRNISSSSFLVAGG 148 Query: 214 YNAKLSDFGLARDGPMGDLSYVSTRVMGTYG--YAAPEYMSSGH--LNARSDVYSFGVLL 269 Y KL+ F L++ + ST+ + Y +PE + + + ++++YSFG++L Sbjct: 149 YQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVL 208 Query: 270 LEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAV 329 EI +GK + SK+ L+ +++ + + + Sbjct: 209 WEIATGKIPFEGC----------------DSKKIRELVAEDKKQEPVGQDCPELLREIIN 252 Query: 330 QCLSFEPKSRPTMDQVVRALQQLQDNLGKP 359 +C + EP RP++D ++ L ++++ K Sbjct: 253 ECRAHEPSQRPSVDGILERLSAVEESTDKK 282 >5UV4-A nrPDB Length = 311 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 92/311 (29%), Positives = 151/311 (48%), Gaps = 32/311 (10%) Query: 55 FTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG 114 FT EL A P +IG G +K LD G ++ VK L + + Sbjct: 20 FTAEELSCA-----PAEIIGRSCHGTSYKATLDN----------GYMLTVKWLKEGFAKS 64 Query: 115 HREWLTEINYLGQLSHPNLVKLIGYCL--EDEHRLLVYEFMQKGSLENHLFR-RGAYFKP 171 +E+ EI LG + HPNLV L GY ++ R+++ ++ SL +L P Sbjct: 65 KKEFSREIKKLGSVRHPNLVPLRGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPP 124 Query: 172 LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILL-DADYNAKLSDFGLARDG-PM 229 L R+N+A+D A+ L +LH++ V + + +IK+SN+L+ ++ +A ++D+ L R P+ Sbjct: 125 LSAGQRLNIAIDIARCLDYLHNERV-IPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPI 183 Query: 230 GDLSYVSTRVMGTYGYAAPEYMSSGHL--NARSDVYSFGVLLLEILSGKRALD-HNRPAK 286 G V G GY+ PE+ S+ + +SDVY+FGV+LLE+L+GK A + Sbjct: 184 GMAEQVLN--AGALGYSPPEFSSTSKPCPSLKSDVYAFGVILLELLTGKIAGEIICMNDG 241 Query: 287 EENLVDWARPYLTSKRKVLLIVDNRL----DTQYLPEEAVRMASVAVQCLSFEPKSRPTM 342 +L DW R L + +V D + ++ P+ M +A++C+ RP + Sbjct: 242 VVDLTDWVR-MLDLEERVSECYDRHITGVESSEGAPQALDGMLRIALRCIR-SASERPEV 299 Query: 343 DQVVRALQQLQ 353 V L L Sbjct: 300 RTVFEDLLSLS 310 >3EB0-A nrPDB Length = 383 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 67/360 (18%), Positives = 134/360 (37%), Gaps = 76/360 (21%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL 119 L+ +++ + +G G FG V + + E +G A+KK+ Q+ +R Sbjct: 2 LETSSKKYSLGKTLGTGSFGIVCEVFDIE---------SGKRFALKKVLQDPRYKNR--- 49 Query: 120 TEINYLGQLSHPNLVKLIGYCL-------------------------------------- 141 E++ + L H N++KL+ Y Sbjct: 50 -ELDIMKVLDHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPS 108 Query: 142 EDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYR 201 ++++ ++ E++ +L L + +P L + + F+HS + + +R Sbjct: 109 QNKYLNVIMEYVP-DTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHS--LGICHR 165 Query: 202 DIKASNILLDA-DYNAKLSDFGLARDGPMGDLS--YVSTRVMGTYGYAAPEYMSS-GHLN 257 DIK N+L+++ D KL DFG A+ + S Y+ +R Y APE M Sbjct: 166 DIKPQNLLVNSKDNTLKLCDFGSAKKLIPSEPSVAYICSRF-----YRAPELMLGATEYT 220 Query: 258 ARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLL----------I 307 D++S G + E++ GK + + T ++ + + Sbjct: 221 PSIDLWSIGCVFGELILGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPT 280 Query: 308 VDNRLDTQYLPEEAVRMA-SVAVQCLSFEPKSRPTMDQVVRA--LQQLQDNLGKPSQTNP 364 + + + LPE +A + Q L +EP R + + L+++ + N Sbjct: 281 LKAKDWRKILPEGTPSLAIDLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYESEVKNNS 340 >3HNG-A nrPDB Length = 360 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 50/197 (25%), Positives = 78/197 (39%), Gaps = 19/197 (9%) Query: 157 SLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA 216 +E G Y +P+ ++ + A+G+ FL S K I+RD+ A NILL + Sbjct: 181 DVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSR--KCIHRDLAARNILLSENNVV 238 Query: 217 KLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILS-G 275 K+ DFGLARD + APE + + +SDV+S+GVLL EI S G Sbjct: 239 KICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLG 298 Query: 276 KRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFE 335 P + + + + + + + C + Sbjct: 299 GSPY----------------PGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRD 342 Query: 336 PKSRPTMDQVVRALQQL 352 PK RP ++V L L Sbjct: 343 PKERPRFAELVEKLGDL 359 Score = 91.7 bits (226), Expect = 5e-19, Method: Composition-based stats. Identities = 28/119 (23%), Positives = 53/119 (44%), Gaps = 7/119 (5%) Query: 54 SFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGF- 112 + ++ + A + +G G FG V + S K T +AVK L + Sbjct: 16 PYDASKWEFARERLKLGKSLGRGAFGKVVQA----SAFGIKKSPTCRTVAVKMLKEGATA 71 Query: 113 QGHREWLTEINYLGQLSHP-NLVKLIGYCL-EDEHRLLVYEFMQKGSLENHLFRRGAYF 169 ++ +TE+ L + H N+V L+G C + +++ E+ + G+L N+L + F Sbjct: 72 SEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLF 130 >5J0A-A nrPDB Length = 300 Score = 165 bits (418), Expect = 3e-41, Method: Composition-based stats. Identities = 65/286 (22%), Positives = 126/286 (44%), Gaps = 15/286 (5%) Query: 77 GFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-----EWLTEINYLGQLSHP 131 GFG G + + AVKK+N +R + E L L HP Sbjct: 18 GFGT---GVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHP 74 Query: 132 NLVKLIGYCL-EDEHRLLVYEFMQKGSLENHLFRR-GAYFKPLPWFLRVNVALDAAKGLA 189 N+V + D L E+ + SL + + R A P P + + VAL+ A+GL Sbjct: 75 NIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLK 134 Query: 190 FLHSDPVKVIYRDIKASNILLDADY-NAKLSDFGLARDGPMG-DLSYVSTRVMGTYGYAA 247 +LH + K+++ DIK+SN+++ D+ K+ D G++ +++ +GT + Sbjct: 135 YLHQEK-KLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPWKP 193 Query: 248 PE-YMSSGHLNARSDVYSFGVLLLEILSGKRA-LDHNRPAKEENLVDWARPYLTSKRKVL 305 E +G + ++D+++FG+ L E+++ ++ + +E+ + Sbjct: 194 KEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAA 253 Query: 306 LIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 L ++ + L E ++ + C + +PK RP+ +V AL+ Sbjct: 254 LGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALET 299 >2WTK-C nrPDB Length = 305 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 55/313 (17%), Positives = 104/313 (33%), Gaps = 38/313 (12%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLG 126 + ++GEG +G V + E+ + G EI L Sbjct: 7 YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKK-----KLRRIPNGEANVKKEIQLLR 61 Query: 127 QLSHPNLVKLIGYC--LEDEHRLLVYEFMQKG--SLENHLFRRGAYFKPLPWFLRVNVAL 182 +L H N+++L+ E + +V E+ G + + + + P Sbjct: 62 RLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKR-----FPVCQAHGYFC 116 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGT 242 GL +LHS ++++DIK N+LL K+S G+A G+ Sbjct: 117 QLIDGLEYLHSQ--GIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGS 174 Query: 243 YGYAAPEYMSSGHL--NARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 + PE + + D++S GV L I +G + + K + + Sbjct: 175 PAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAI-- 232 Query: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA--LQQLQDNLGK 358 + ++ + L +EP R ++ Q+ + ++ Sbjct: 233 ----------------PGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEA 276 Query: 359 PSQTNPVKDTKKL 371 P P DTK Sbjct: 277 PVPIPPSPDTKDR 289 >3DLS-A nrPDB Length = 335 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 63/283 (22%), Positives = 102/283 (36%), Gaps = 34/283 (12%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR------- 116 ++ + S +G G FG V+ E + VK + +E Sbjct: 23 SQKYSTMSPLGSGAFGFVWTAVDKEK---------NKEVVVKFIKKEKVLEDCWIEDPKL 73 Query: 117 -EWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKG-SLENHLFRRGAYFKPLPW 174 + EI L ++ H N++K++ LV E G L + R +PL Sbjct: 74 GKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLA- 132 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSY 234 + + +L +I+RDIK NI++ D+ KL DFG A G L Y Sbjct: 133 ---SYIFRQLVSAVGYL--RLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFY 187 Query: 235 VSTRVMGTYGYAAPEYMSSGHL-NARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDW 293 GT Y APE + +++S GV L ++ + +E Sbjct: 188 ---TFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCE---LEETVEAAI 241 Query: 294 ARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEP 336 PYL SK + L+ Q +PE + + +P Sbjct: 242 HPPYLVSKELMSLVSGL---LQPVPERRTTLEKLVTDPWVTQP 281 >6O6Q-A nrPDB Length = 335 Score = 164 bits (416), Expect = 4e-41, Method: Composition-based stats. Identities = 59/347 (17%), Positives = 129/347 (37%), Gaps = 51/347 (14%) Query: 29 SRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLA---TRNFRPDSVIGEGGFGCVFKGW 85 S +TV + + ++LS+ P + +++L + N+ +G G + VF G Sbjct: 2 SSHRHNTVQSVSRVYADVLSTKPQSYWDYDDLNIKWNPQENYEILRKLGRGKYSEVFLGI 61 Query: 86 LDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQL-SHPNLVKLIGYCLEDE 144 E + +K L ++ EI+ L L PN++ ++ E + Sbjct: 62 DLEKR---------EKVVIKVLKP---VKRKKIKREISILKNLVDGPNIIAMLDVVREPQ 109 Query: 145 HRL--LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRD 202 + L++E + + + + + K L + HS + +++RD Sbjct: 110 SKTPGLIFEHINN-------IDFRSLYPTFTDYDIRFYMYELLKALDYSHS--MGIMHRD 160 Query: 203 IKASNILLDADYNA-KLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM-SSGHLNARS 260 +K N+++D D +L D+GLA G V + + + PE + + Sbjct: 161 VKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVR---VASRYFKGPELLVDYRLYDYSL 217 Query: 261 DVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQY---- 316 D++SFG +L ++ K H + ++ + + +K L + L +Y Sbjct: 218 DMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISLGEEYEDIG 277 Query: 317 ---------LPEE------AVRMASVAVQCLSFEPKSRPTMDQVVRA 348 E + + + L ++ + R T + ++ Sbjct: 278 YYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKH 324 >5TE0-A nrPDB Length = 347 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 60/300 (20%), Positives = 107/300 (35%), Gaps = 49/300 (16%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTE 121 + + D V+ EGGF VF + G+ A+K++ + E Sbjct: 16 IGRQQVTVDEVLAEGGFAIVFL----------VRTSNGMKCALKRMFVNNEHDLQVCKRE 65 Query: 122 INYLGQLS-HPNLVKLIGYCLEDE------HRLLVYEFMQKGSLENHLFRRGAYFKPLPW 174 I + LS H N+V I + + L++ +F + G + N + +R Sbjct: 66 IQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQR--LQTGFTE 123 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSY 234 + + D + +A LH +I+RD+K NILL + L DFG A + + Sbjct: 124 NEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTE 183 Query: 235 VSTRV------MGTYGYAAPEYMS---SGHLNARSDVYSFGVLLLEILSGKRALDHNRPA 285 V T Y APE ++ + ++D+++ G LL ++ ++ Sbjct: 184 GVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQ-- 241 Query: 286 KEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQV 345 + I D + M + L +P RP + QV Sbjct: 242 -------------------VAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQV 282 >5X8I-B nrPDB Length = 346 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 66/334 (19%), Positives = 118/334 (35%), Gaps = 70/334 (20%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 + +GEG FG V + G +AVK + + +EI L Sbjct: 14 RYEIVDTLGEGAFGKVVECI--------DHKAGGRHVAVKIVKNVD-RYCEAARSEIQVL 64 Query: 126 GQLS--HPN----LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 L+ PN V+++ + H +V+E + L + F + F P Sbjct: 65 EHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLG---LSTYDFIKENGFLPFRLDHIRK 121 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDA-------------------DYNAKLSD 220 +A K + FLHS+ K+ + D+K NIL + + K+ D Sbjct: 122 MAYQICKSVNFLHSN--KLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVD 179 Query: 221 FGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 FG A + VS T Y APE + + + DV+S G +L+E G Sbjct: 180 FGSATYDDEHHSTLVS-----TRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFP 234 Query: 281 HNRPAKEENLVD-----WARPYLTSKRKVLLIVDNRLD-------TQYLPEEAV------ 322 + + +++ + + RK +RLD +Y+ Sbjct: 235 THDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFM 294 Query: 323 --------RMASVAVQCLSFEPKSRPTMDQVVRA 348 R+ + + L ++P R T+ + ++ Sbjct: 295 LSQDVEHERLFDLIQKMLEYDPAKRITLREALKH 328 >2RIO-A nrPDB Length = 434 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 65/305 (21%), Positives = 118/305 (38%), Gaps = 54/305 (17%) Query: 70 DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLS 129 + ++G G G V G +AVK++ L EI L + Sbjct: 20 EKILGYGSSGTV----------VFQGSFQGRPVAVKRML---IDFCDIALMEIKLLTESD 66 Query: 130 -HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLP---WFLRVNVALDAA 185 HPN+++ D + E +L++ + + + L + +++ A Sbjct: 67 DHPNVIRYYCSETTDRFLYIALELCNL-NLQDLVESKNVSDENLKLQKEYNPISLLRQIA 125 Query: 186 KGLAFLHSDPVKVIYRDIKASNILLD-------------ADYNAKLSDFGLARDGPMGDL 232 G+A LHS +K+I+RD+K NIL+ + +SDFGL + G Sbjct: 126 SGVAHLHS--LKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQS 183 Query: 233 SYVS--TRVMGTYGYAAPEYMSS-------GHLNARSDVYSFGVLLLEILSGKRALDHNR 283 S+ + GT G+ APE + L D++S G + ILS + ++ Sbjct: 184 SFRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDK 243 Query: 284 PAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMD 343 ++E N++ + S ++ + D L + Q + +P RPT Sbjct: 244 YSRESNIIRG----IFSLDEMKCLHDRSL--------IAEATDLISQMIDHDPLKRPTAM 291 Query: 344 QVVRA 348 +V+R Sbjct: 292 KVLRH 296 >6B2Q-A nrPDB Length = 317 Score = 162 bits (409), Expect = 3e-40, Method: Composition-based stats. Identities = 59/226 (26%), Positives = 93/226 (41%), Gaps = 24/226 (10%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE---GFQGHREWLTEI 122 +R +I GG G V++ + G +AVK L E + + E Sbjct: 33 RYRLQRLIATGGMGQVWEAVDNRL---------GRRVAVKVLKSEFSSDPEFIERFRAEA 83 Query: 123 NYLGQLSHPNLVKLIGYCL-----EDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 L+HP + + Y E LV E + L + L R G L Sbjct: 84 RTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR----LSLRHA 139 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 +++ + L H+ +++RD+K NIL+ K++DFG+A+ ++ + Sbjct: 140 LDMLEQTGRALQIAHA--AGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVT-QTG 196 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNR 283 VMGT Y APE + SDVYS GV+ E +SGKR + Sbjct: 197 MVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDG 242 >4X3F-A nrPDB Length = 337 Score = 162 bits (409), Expect = 3e-40, Method: Composition-based stats. Identities = 59/226 (26%), Positives = 93/226 (41%), Gaps = 24/226 (10%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE---GFQGHREWLTEI 122 +R +I GG G V++ + G +AVK L E + + E Sbjct: 13 RYRLQRLIATGGMGQVWEAVDNRL---------GRRVAVKVLKSEFSSDPEFIERFRAEA 63 Query: 123 NYLGQLSHPNLVKLIGYCL-----EDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 L+HP + + Y E LV E + L + L R G L Sbjct: 64 RTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR----LSLRHA 119 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 +++ + L H+ +++RD+K NIL+ K++DFG+A+ ++ + Sbjct: 120 LDMLEQTGRALQIAHA--AGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVT-QTG 176 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNR 283 VMGT Y APE + SDVYS GV+ E +SGKR + Sbjct: 177 MVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDG 222 >4OW8-A nrPDB Length = 283 Score = 162 bits (409), Expect = 3e-40, Method: Composition-based stats. Identities = 59/226 (26%), Positives = 93/226 (41%), Gaps = 24/226 (10%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE---GFQGHREWLTEI 122 +R +I GG G V++ + G +AVK L E + + E Sbjct: 12 RYRLQRLIATGGMGQVWEAVDNRL---------GRRVAVKVLKSEFSSDPEFIERFRAEA 62 Query: 123 NYLGQLSHPNLVKLIGYCL-----EDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 L+HP + + Y E LV E + L + L R G L Sbjct: 63 RTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR----LSLRHA 118 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 +++ + L H+ +++RD+K NIL+ K++DFG+A+ ++ + Sbjct: 119 LDMLEQTGRALQIAHA--AGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVT-QTG 175 Query: 238 RVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNR 283 VMGT Y APE + SDVYS GV+ E +SGKR + Sbjct: 176 MVMGTAQYIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDG 221 >6FYV-A nrPDB Length = 337 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 67/334 (20%), Positives = 121/334 (36%), Gaps = 70/334 (20%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 + +GEG FG V + G+ +AVK + G + +EI L Sbjct: 15 RYEIVDTLGEGAFGKVVECI--------DHGMDGMHVAVKIVKNVG-RYREAARSEIQVL 65 Query: 126 GQLSH--PN----LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 L+ PN V+++ + H +V+E + L + F + F P Sbjct: 66 EHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLG---LSTYDFIKENSFLPFQIDHIRQ 122 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDA-------------------DYNAKLSD 220 +A + + FLH + K+ + D+K NIL + + K+ D Sbjct: 123 MAYQICQSINFLHHN--KLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVD 180 Query: 221 FGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALD 280 FG A + VS T Y APE + + + DV+S G +L+E G Sbjct: 181 FGSATYDDEHHSTLVS-----TRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQ 235 Query: 281 HNRPAKEENLVD-----WARPYLTSKRKVLLIVDNRLD------------TQYLP----- 318 + + +++ + + RK N+LD + P Sbjct: 236 THDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFM 295 Query: 319 ----EEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 EE ++ + + L ++P R T+D+ ++ Sbjct: 296 LCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQH 329 >2WO6-A nrPDB Length = 382 Score = 161 bits (406), Expect = 7e-40, Method: Composition-based stats. Identities = 52/236 (22%), Positives = 95/236 (40%), Gaps = 26/236 (11%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEIN 123 + DS+IG+G FG V K + +A+K + + ++ + E+ Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAY---------DRVEQEWVAIKIIKNKKAFLNQAQI-EVR 102 Query: 124 YLGQL-SHP-----NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 L + H +V L + + H LV+E + +L + L R F+ + L Sbjct: 103 LLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSY-NLYDLL--RNTNFRGVSLNLT 159 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN--AKLSDFGLARDGPMGDLSYV 235 A L FL + + +I+ D+K NILL K+ DFG + Y+ Sbjct: 160 RKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYI 219 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLV 291 +R Y +PE + + D++S G +L+E+ +G+ + N + Sbjct: 220 QSRF-----YRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKI 270 >6HV0-A nrPDB Length = 416 Score = 161 bits (406), Expect = 7e-40, Method: Composition-based stats. Identities = 68/336 (20%), Positives = 129/336 (38%), Gaps = 59/336 (17%) Query: 67 FRPDSVIGEGGFGC-VFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 F P V+G G G V++G D +AVK++ E F E+ L Sbjct: 10 FCPKDVLGHGAEGTIVYRGMFDNRD-----------VAVKRILPECFSFAD---REVQLL 55 Query: 126 GQLS-HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 + HPN+++ + + + + E +L+ ++ ++ L + Sbjct: 56 RESDEHPNVIRYFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLQ---QT 111 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILL---DADYNAK--LSDFGLARDGPMGDLSY-VSTR 238 GLA LHS + +++RD+K NIL+ +A K +SDFGL + +G S+ + Sbjct: 112 TSGLAHLHS--LNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSG 169 Query: 239 VMGTYGYAAPEYMSS---GHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWA 294 V GT G+ APE +S + D++S G + ++S G + + L+ Sbjct: 170 VPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGAC 229 Query: 295 RPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA------ 348 K ++ + + ++ +P+ RP+ V++ Sbjct: 230 SLDCLHPEKHEDVI---------------ARELIEKMIAMDPQKRPSAKHVLKHPFFWSL 274 Query: 349 ------LQQLQDNLGKPSQTNPVKDTKKLGFKTGTT 378 Q + D + K S P+ + G + Sbjct: 275 EKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVK 310 >3VHK-A nrPDB Length = 368 Score = 160 bits (405), Expect = 9e-40, Method: Composition-based stats. Identities = 59/205 (28%), Positives = 80/205 (39%), Gaps = 22/205 (10%) Query: 152 FMQKGSLENHLFRR---GAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNI 208 F+++ SL + Y L + + AKG+ FL S K I+RD+ A NI Sbjct: 174 FVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASR--KCIHRDLAARNI 231 Query: 209 LLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVL 268 LL K+ DFGLARD + APE + +SDV+SFGVL Sbjct: 232 LLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVL 291 Query: 269 LLEILS-GKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASV 327 L EI S G + +E R++ R PE M Sbjct: 292 LWEIFSLGASPYPGVKIDEEF------------CRRLKEGTRMRAPDYTTPE----MYQT 335 Query: 328 AVQCLSFEPKSRPTMDQVVRALQQL 352 + C EP RPT ++V L L Sbjct: 336 MLDCWHGEPSQRPTFSELVEHLGNL 360 Score = 91.3 bits (225), Expect = 6e-19, Method: Composition-based stats. Identities = 30/121 (24%), Positives = 51/121 (42%), Gaps = 7/121 (5%) Query: 54 SFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ-EGF 112 + ++ + + +G G FG V + K T +AVK L + Sbjct: 18 PYDASKWEFPRDRLKLGKPLGRGAFGQVIEA----DAFGIDKTATCRTVAVKMLKEGATH 73 Query: 113 QGHREWLTEINYLGQLSHP-NLVKLIGYCLEDEHRLLVY-EFMQKGSLENHLFRRGAYFK 170 HR ++E+ L + H N+V L+G C + L+V EF + G+L +L + F Sbjct: 74 SEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFV 133 Query: 171 P 171 P Sbjct: 134 P 134 >5IKW-A nrPDB Length = 310 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 60/301 (19%), Positives = 109/301 (36%), Gaps = 48/301 (15%) Query: 60 LKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL 119 + + + EGGF VF + G+ A+K++ Sbjct: 9 FAVGRHQVTLEESLAEGGFSTVFL----------VRTHGGIRCALKRMYVNNMPDLNVCK 58 Query: 120 TEINYLGQLS-HPNLVKLIGYCLEDE-----HRLLVYEFMQKGSLENHLFRRGAYFKPLP 173 EI + +LS H N+V + + L++ E+ + G + N + ++ P Sbjct: 59 REITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEP 118 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARD---GPMG 230 L + D + +A LH +I+RD+K NILL+ N L DFG A + P Sbjct: 119 EVL--QIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQK 176 Query: 231 DLSYVSTRVM---GTYGYAAPEYMS---SGHLNARSDVYSFGVLLLEILSGKRALDHNRP 284 D V + T Y APE ++ + ++D+++ G LL ++ ++ Sbjct: 177 DGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQ- 235 Query: 285 AKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQ 344 + I D + + + L +P+ RP + Q Sbjct: 236 --------------------VAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQ 275 Query: 345 V 345 V Sbjct: 276 V 276 >4PL5-B nrPDB Length = 435 Score = 158 bits (399), Expect = 4e-39, Method: Composition-based stats. Identities = 69/336 (20%), Positives = 130/336 (38%), Gaps = 59/336 (17%) Query: 67 FRPDSVIGEGGFGC-VFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 F P V+G G G V+KG D +AVK++ E F E+ L Sbjct: 29 FCPKDVLGHGAEGTIVYKGMFDNRD-----------VAVKRILPECFSFAD---REVQLL 74 Query: 126 GQLS-HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 + HPN+++ + + + + E +L+ ++ ++ L ++ Sbjct: 75 RESDEHPNVIRYFCTEKDRQFQYIAIELCAA-TLQEYVEQKDFAHLGLEPITLLH---QT 130 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILL---DADYNAK--LSDFGLARDGPMGDLSY-VSTR 238 GLA LHS + +++RD+K NILL +A K +SDFGL + +G S+ + Sbjct: 131 TSGLAHLHS--LNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSG 188 Query: 239 VMGTYGYAAPEYMSS---GHLNARSDVYSFGVLLLEILS-GKRALDHNRPAKEENLVDWA 294 V GT G+ APE +S + D++S G + ++S G + + L+ Sbjct: 189 VPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILLGAC 248 Query: 295 RPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA------ 348 K ++ + + ++ +P+ RP+ V++ Sbjct: 249 NLDCFHSDKHEDVI---------------ARELIEKMIAMDPQQRPSAKHVLKHPFFWSL 293 Query: 349 ------LQQLQDNLGKPSQTNPVKDTKKLGFKTGTT 378 Q + D + K + P+ + G + Sbjct: 294 EKQLQFFQDVSDRIEKEALDGPIVRQLERGGRAVVK 329 >4CRL-A nrPDB Length = 406 Score = 157 bits (398), Expect = 6e-39, Method: Composition-based stats. Identities = 64/349 (18%), Positives = 126/349 (36%), Gaps = 61/349 (17%) Query: 58 NELKLATRNFRPD-SVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR 116 +E + F + +G G +G V+ A+K++ EG Sbjct: 14 SERERVEDLFEYEGCKVGRGTYGHVY-------KAKRKDGKDDKDYALKQI--EGTGISM 64 Query: 117 EWLTEINYLGQLSHPNLVKLIGYCLE--DEHRLLVYEFMQKGSLENHLFRRGAYFKP--- 171 EI L +L HPN++ L L D L++++ + F R + Sbjct: 65 SACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPV 124 Query: 172 -LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLD----ADYNAKLSDFGLARD 226 LP + ++ G+ +LH++ V++RD+K +NIL+ K++D G AR Sbjct: 125 QLPRGMVKSLLYQILDGIHYLHANW--VLHRDLKPANILVMGEGPERGRVKIADMGFARL 182 Query: 227 G-PMGDLSYVSTRVMGTYGYAAPEYMSS-GHLNARSDVYSFGVLLLEILSGKRALDHNRP 284 V+ T+ Y APE + H D+++ G + E+L+ + Sbjct: 183 FNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFH---- 238 Query: 285 AKEENLVDWARPYLTSKRKVLLIVDNRLDTQY-----LPEEAVRMAS------------- 326 ++E++ + ++ ++ D + +PE + M Sbjct: 239 CRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIK 298 Query: 327 ---------------VAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPS 360 + + L+ +P R T +Q ++ L+D L Sbjct: 299 YMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSD 347 >4LQP-A nrPDB Length = 508 Score = 157 bits (397), Expect = 7e-39, Method: Composition-based stats. Identities = 59/307 (19%), Positives = 96/307 (31%), Gaps = 77/307 (25%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW---LTE 121 +F VIG+G FG V K TG + A+K L + + E Sbjct: 102 EDFHTVKVIGKGAFGEV---------RLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAE 152 Query: 122 INYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 + L P +V L + ++ L+ EF+ G L L R + + + F Sbjct: 153 RDVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECI 212 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVM- 240 L + +H + I+R IK NIL+D + KLSDFGL+ S +++ Sbjct: 213 L----AIETIH--KLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQ 266 Query: 241 -----------GTYG------------------------------Y------AA------ 247 GTY + A Sbjct: 267 QDEATNGISKPGTYNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGT 326 Query: 248 PEYM-----SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 P+Y+ D +S G ++ E L G P + + L Sbjct: 327 PDYIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPD 386 Query: 303 KVLLIVD 309 + + + Sbjct: 387 DIHISYE 393 >5VD3-A nrPDB Length = 311 Score = 157 bits (396), Expect = 9e-39, Method: Composition-based stats. Identities = 78/335 (23%), Positives = 118/335 (35%), Gaps = 42/335 (12%) Query: 16 NGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGE 75 +G L S + + E +P + E ++F+ S +G Sbjct: 9 SGVDLGTENLYFQSMHQLQPRRVSFRGEASETLQSPGYDPSRPE-SFFQQSFQRLSRLGH 67 Query: 76 GGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTEINYLGQL-SHPN 132 G +G VFK E G + AVK+ G + L E+ ++ HP Sbjct: 68 GSYGEVFKVRSKED---------GRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPC 118 Query: 133 LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 V+L E L E SL+ H GA LP D LA LH Sbjct: 119 CVRLEQAWEEGGILYLQTELC-GPSLQQHCEAWGAS---LPEAQVWGYLRDTLLALAHLH 174 Query: 193 SDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMS 252 S +++ D+K +NI L KL DFGL + V G Y APE + Sbjct: 175 SQ--GLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQE---GDPRYMAPELLQ 229 Query: 253 SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRL 312 G +DV+S G+ +LE+ + P E + Y L Sbjct: 230 -GSYGTAADVFSLGLTILEVAC-----NMELPHGGEGWQQLRQGY--------------L 269 Query: 313 DTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 ++ + + SV V L +PK R T + ++ Sbjct: 270 PPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLA 304 >4JLC-A nrPDB Length = 657 Score = 154 bits (390), Expect = 5e-38, Method: Composition-based stats. Identities = 59/226 (26%), Positives = 90/226 (39%), Gaps = 30/226 (13%) Query: 69 PDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW-LTEINYLGQ 127 ++G+G VF+G TG + AVK N F + + E L + Sbjct: 12 LSDILGQGATANVFRG---------RHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKK 62 Query: 128 LSHPNLVKLIGYCLEDE--HRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 L+H N+VKL E H++L+ EF GSL L + LP + V D Sbjct: 63 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVL-EEPSNAYGLPESEFLIVLRDVV 121 Query: 186 KGLAFLHSDPVKVIYRDIKASNIL--LDADYNA--KLSDFGLARDGPMGDLSYVSTRVMG 241 G+ L + +++RDIK NI+ + D + KL+DFG AR+ + + G Sbjct: 122 GGMNHLREN--GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAAREL---EDDEQFVSLYG 176 Query: 242 TYGYAAPEYMS--------SGHLNARSDVYSFGVLLLEILSGKRAL 279 T Y P+ A D++S GV +G Sbjct: 177 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPF 222 >2H34-A nrPDB Length = 309 Score = 154 bits (388), Expect = 8e-38, Method: Composition-based stats. Identities = 57/276 (20%), Positives = 103/276 (37%), Gaps = 34/276 (12%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQG---HREWLTEIN 123 +R ++G GG G V++ ++A+K +++ E Sbjct: 36 YRLRRLVGRGGMGDVYEA---------EDTVRERIVALKLMSETLSSDPVFRTRMQREAR 86 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 G+L P++V + + D + + L L R+G P + + Sbjct: 87 TAGRLQEPHVVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGPLAPPRAVAIVRQIGSA 146 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTY 243 + +RD+K NIL+ AD A L DFG+A L+ + +GT Sbjct: 147 LDA------AHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNT-VGTL 199 Query: 244 GYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRK 303 Y APE S H R+D+Y+ +L E L+G ++ + ++ A P ++ R Sbjct: 200 YYMAPERFSESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVR- 258 Query: 304 VLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSR 339 P V +V + ++ P+ R Sbjct: 259 --------------PGIPVAFDAVIARGMAKNPEDR 280 >1TKI-A nrPDB Length = 321 Score = 154 bits (388), Expect = 9e-38, Method: Composition-based stats. Identities = 58/313 (18%), Positives = 104/313 (33%), Gaps = 39/313 (12%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEIN 123 + +G G FG V + + K + VK EI+ Sbjct: 4 YEKYMIAEDLGRGEFGIVHRC----VETSSKKTYMAKFVKVK------GTDQVLVKKEIS 53 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 L H N++ L E ++++EF+ + + L V+ Sbjct: 54 ILNIARHRNILHLHESFESMEELVMIFEFISGLDIFERI---NTSAFELNEREIVSYVHQ 110 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDA--DYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 + L FLHS + + DI+ NI+ K+ +FG AR GD + Sbjct: 111 VCEALQFLHSH--NIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTA-- 166 Query: 242 TYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSK 301 Y APE ++ +D++S G L+ +LSG L + + + + Sbjct: 167 -PEYYAPEVHQHDVVSTATDMWSLGTLVYVLLSGINPF----------LAETNQQIIENI 215 Query: 302 RKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQ 361 D + E ++ + L E KSR T + ++ L + + Sbjct: 216 MNAEYTFDE----EAFKEISIEAMDFVDRLLVKERKSRMTASEALQH-----PWLKQKIE 266 Query: 362 TNPVKDTKKLGFK 374 K + L + Sbjct: 267 RVSTKVIRTLKHR 279 >2WTK-B nrPDB Length = 373 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 65/357 (18%), Positives = 116/357 (32%), Gaps = 56/357 (15%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR-EWLT-EINY 124 + +VIG+G F + TG + V+++N E +L E++ Sbjct: 11 YELLTVIGKG-F------EDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHV 63 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 +HPN+V + D +V FM GS ++ + + + + Sbjct: 64 SKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTH--FMDGMNELAIAYILQGV 121 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRV----- 239 K L ++H + ++R +KAS+IL+ D LS GL + M V Sbjct: 122 LKALDYIHH--MGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPK 177 Query: 240 --MGTYGYAAPEYMSSG--HLNARSDVYSFGVLLLEILSGKRALDHNR------------ 283 + + +PE + +A+SD+YS G+ E+ +G Sbjct: 178 YSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGT 237 Query: 284 ----------PAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEA------VRMASV 327 PA+E + + L R P Sbjct: 238 VPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHF 297 Query: 328 AVQCLSFEPKSRPTMDQVVRA--LQQLQD--NLGKPSQTNPVKDTKKLGFKTGTTKS 380 QCL P +RP+ ++ +Q++ + P PV S Sbjct: 298 VEQCLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQDHS 354 >4EUU-A nrPDB Length = 319 Score = 153 bits (386), Expect = 1e-37, Method: Composition-based stats. Identities = 64/301 (21%), Positives = 108/301 (35%), Gaps = 49/301 (16%) Query: 69 PDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW-LTEINYLGQ 127 ++G+G VF+G TG + A+K N F + + E L + Sbjct: 13 LSDILGQGATANVFRG---------RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 63 Query: 128 LSHPNLVKLIGYCLEDE--HRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 L+H N+VKL E H++L+ EF GSL L + LP + V D Sbjct: 64 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVL-EEPSNAYGLPESEFLIVLRDVV 122 Query: 186 KGLAFLHSDPVKVIYRDIKASNIL--LDADYNA--KLSDFGLARDGPMGDLSYVSTRVMG 241 G+ L + +++R+IK NI+ + D + KL+DFG AR+ + + G Sbjct: 123 GGMNHLREN--GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL---EDDEQFVSLYG 177 Query: 242 TYGYAAPEYMS--------SGHLNARSDVYSFGVLLLEILSGKRAL-DHNRPAKEENLV- 291 T Y P+ A D++S GV +G P + + ++ Sbjct: 178 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMY 237 Query: 292 -----------------DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSF 334 + + V + L P A + + +C F Sbjct: 238 KIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGF 297 Query: 335 E 335 + Sbjct: 298 D 298 >4EUT-A nrPDB Length = 396 Score = 153 bits (386), Expect = 1e-37, Method: Composition-based stats. Identities = 64/301 (21%), Positives = 108/301 (35%), Gaps = 49/301 (16%) Query: 69 PDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW-LTEINYLGQ 127 ++G+G VF+G TG + A+K N F + + E L + Sbjct: 13 LSDILGQGATANVFRG---------RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 63 Query: 128 LSHPNLVKLIGYCLEDE--HRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 L+H N+VKL E H++L+ EF GSL L + LP + V D Sbjct: 64 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVL-EEPSNAYGLPESEFLIVLRDVV 122 Query: 186 KGLAFLHSDPVKVIYRDIKASNIL--LDADYNA--KLSDFGLARDGPMGDLSYVSTRVMG 241 G+ L + +++R+IK NI+ + D + KL+DFG AR+ + + G Sbjct: 123 GGMNHLREN--GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL---EDDEQFVSLYG 177 Query: 242 TYGYAAPEYMS--------SGHLNARSDVYSFGVLLLEILSGKRAL-DHNRPAKEENLV- 291 T Y P+ A D++S GV +G P + + ++ Sbjct: 178 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMY 237 Query: 292 -----------------DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSF 334 + + V + L P A + + +C F Sbjct: 238 KIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGF 297 Query: 335 E 335 + Sbjct: 298 D 298 >6O8B-A nrPDB Length = 665 Score = 152 bits (384), Expect = 2e-37, Method: Composition-based stats. Identities = 64/301 (21%), Positives = 108/301 (35%), Gaps = 49/301 (16%) Query: 69 PDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW-LTEINYLGQ 127 ++G+G VF+G TG + A+K N F + + E L + Sbjct: 19 LSDILGQGATANVFRG---------RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 69 Query: 128 LSHPNLVKLIGYCLEDE--HRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 L+H N+VKL E H++L+ EF GSL L + LP + V D Sbjct: 70 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVL-EEPSNAYGLPESEFLIVLRDVV 128 Query: 186 KGLAFLHSDPVKVIYRDIKASNIL--LDADYNA--KLSDFGLARDGPMGDLSYVSTRVMG 241 G+ L + +++R+IK NI+ + D + KL+DFG AR+ + + G Sbjct: 129 GGMNHLREN--GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL---EDDEQFVELYG 183 Query: 242 TYGYAAPEYMS--------SGHLNARSDVYSFGVLLLEILSGKRAL-DHNRPAKEENLV- 291 T Y P+ A D++S GV +G P + + ++ Sbjct: 184 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMY 243 Query: 292 -----------------DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSF 334 + + V + L P A + + +C F Sbjct: 244 KIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGF 303 Query: 335 E 335 + Sbjct: 304 D 304 >4RT7-A nrPDB Length = 415 Score = 152 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 51/233 (21%), Positives = 80/233 (34%), Gaps = 33/233 (14%) Query: 120 TEINYLGQLSHPN---LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 E+ HP+ + L G E E+ + LE L + Sbjct: 198 REVQI-----HPDSDQISGLHGNSFHSEDE---IEYENQKRLEE-----EEDLNVLTFED 244 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVS 236 + A AKG+ FL ++RD+ A N+L+ K+ DFGLARD V Sbjct: 245 LLCFAYQVAKGMEFLEFKS--CVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVR 302 Query: 237 TRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 + APE + G +SDV+S+G+LL EI S P Sbjct: 303 GNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDA--------- 353 Query: 297 YLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRAL 349 ++ N + + C +F+ + RP+ + L Sbjct: 354 ------NFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 400 Score = 112 bits (279), Expect = 3e-25, Method: Composition-based stats. Identities = 33/113 (29%), Positives = 51/113 (45%), Gaps = 6/113 (5%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW 118 + + N V+G G FG V + +K G + +AVK L ++ RE Sbjct: 59 KWEFPRENLEFGKVLGSGAFGKVMNA----TAYGISKTGVSIQVAVKMLKEKADSSEREA 114 Query: 119 LT-EINYLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYF 169 L E+ + QL SH N+V L+G C L++E+ G L N+L + F Sbjct: 115 LMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKF 167 >6NT9-A nrPDB Length = 742 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 64/301 (21%), Positives = 108/301 (35%), Gaps = 49/301 (16%) Query: 69 PDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW-LTEINYLGQ 127 ++G+G VF+G TG + A+K N F + + E L + Sbjct: 11 LSDILGQGATANVFRG---------RHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKK 61 Query: 128 LSHPNLVKLIGYCLEDE--HRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 L+H N+VKL E H++L+ EF GSL L + LP + V D Sbjct: 62 LNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVL-EEPSNAYGLPESEFLIVLRDVV 120 Query: 186 KGLAFLHSDPVKVIYRDIKASNIL--LDADYNA--KLSDFGLARDGPMGDLSYVSTRVMG 241 G+ L + +++R+IK NI+ + D + KL+DFG AR+ + + G Sbjct: 121 GGMNHLREN--GIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAAREL---EDDEQFVSLYG 175 Query: 242 TYGYAAPEYMS--------SGHLNARSDVYSFGVLLLEILSGKRAL-DHNRPAKEENLV- 291 T Y P+ A D++S GV +G P + + ++ Sbjct: 176 TEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMY 235 Query: 292 -----------------DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSF 334 + + V + L P A + + +C F Sbjct: 236 KIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGF 295 Query: 335 E 335 + Sbjct: 296 D 296 >5C01-A nrPDB Length = 342 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 69/306 (22%), Positives = 127/306 (41%), Gaps = 55/306 (17%) Query: 73 IGEGGFGCVFKGWL---------------DESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 +G+G V++G L ++ + G L + +K L+ Sbjct: 66 LGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALA 125 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 + + + Q+SH +L + G C+ ++V E+++ G L+ L R + P+ W + Sbjct: 126 FYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHV-PMAW--K 182 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN-------AKLSDFGLARDGPMG 230 + VA A L++L + +++ ++ NILL KLSD G+ G Sbjct: 183 MVVAQQLASALSYLENK--NLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGV------G 234 Query: 231 DLSYVSTRVMGTYGYAAPEYMSSG--HLNARSDVYSFGVLLLEI-LSGKRALDHNRPAKE 287 + + + APE + G L+ D + FG LLEI G+ L P+++ Sbjct: 235 LGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEK 294 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 E+ +RL P ++A++ QCL++EP RP+ ++R Sbjct: 295 EHF---------------YQRQHRLPEPSCP----QLATLTSQCLTYEPTQRPSFRTILR 335 Query: 348 ALQQLQ 353 L +LQ Sbjct: 336 DLTRLQ 341 >4WOV-A nrPDB Length = 317 Score = 147 bits (371), Expect = 7e-36, Method: Composition-based stats. Identities = 68/305 (22%), Positives = 126/305 (41%), Gaps = 55/305 (18%) Query: 73 IGEGGFGCVFKGWL---------------DESTLTPTKPGTGLVIAVKKLNQEGFQGHRE 117 +G+G V++G L ++ + G L + +K L+ Sbjct: 43 LGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALA 102 Query: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 + + + Q+SH +L + G C+ ++V E+++ G L+ L R + P+ W + Sbjct: 103 FYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHV-PMAW--K 159 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN-------AKLSDFGLARDGPMG 230 + VA A L++L + +++ ++ NILL KLSD G+ G Sbjct: 160 MVVAQQLASALSYLENK--NLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGV------G 211 Query: 231 DLSYVSTRVMGTYGYAAPEYMSSG--HLNARSDVYSFGVLLLEI-LSGKRALDHNRPAKE 287 + + + APE + G L+ D + FG LLEI G+ L P+++ Sbjct: 212 LGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEK 271 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 E+ +RL P ++A++ QCL++EP RP+ ++R Sbjct: 272 EHF---------------YQRQHRLPEPSCP----QLATLTSQCLTYEPTQRPSFRTILR 312 Query: 348 ALQQL 352 L +L Sbjct: 313 DLTRL 317 >4IAN-A nrPDB Length = 358 Score = 145 bits (365), Expect = 4e-35, Method: Composition-based stats. Identities = 58/324 (17%), Positives = 110/324 (33%), Gaps = 66/324 (20%) Query: 74 GEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHP-- 131 G+G F V + + +AVK + + L E+ +L +L+ Sbjct: 39 GQGVFSNVVRARDNARA--------NQEVAVKIIRNNELM-QKTGLKELEFLKKLNDADP 89 Query: 132 ----NLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKG 187 + ++L + +H LV+E + +L L + G L + + Sbjct: 90 DDKFHCLRLFRHFYHKQHLCLVFEPLSM-NLREVLKKYGKDV-GLHIKAVRSYSQQLFLA 147 Query: 188 LAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFGLARDGPMGDLSYVSTRVMGTYGYA 246 L L +++ DIK NIL++ KL DFG A D+ T + + Y Sbjct: 148 LKLL--KRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDI----TPYLVSRFYR 201 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLL 306 APE + + D++S G L E+ +GK L + + +K Sbjct: 202 APEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKG 261 Query: 307 IVDNR--------------------------------------LDTQYLPEE----AVRM 324 + ++ + Q LPE+ ++ Sbjct: 262 VFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQL 321 Query: 325 ASVAVQCLSFEPKSRPTMDQVVRA 348 + Q L +P R +++Q ++ Sbjct: 322 KDLLDQILMLDPAKRISINQALQH 345 >2PMN-X nrPDB Length = 348 Score = 144 bits (363), Expect = 7e-35, Method: Composition-based stats. Identities = 55/316 (17%), Positives = 110/316 (34%), Gaps = 55/316 (17%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW------ 118 ++R + +G F + D A+KK + + R++ Sbjct: 31 NDYRIIRTLNQGKFNKIILCEKDN-----------KFYALKKYEKSLLEKKRDFTKSNND 79 Query: 119 -----------LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGA 167 E+ + + + + G + ++YE+M+ S + + Sbjct: 80 KISIKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDS----ILKFDE 135 Query: 168 YFKPLPWFLRVNVALDAAKGL--------AFLHSDPVKVIYRDIKASNILLDADYNAKLS 219 YF L + + K + +++H++ + +RD+K SNIL+D + KLS Sbjct: 136 YFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEK-NICHRDVKPSNILMDKNGRVKLS 194 Query: 220 DFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM-SSGHLN-ARSDVYSFGVLLLEILSGKR 277 DFG + + GTY + PE+ + N A+ D++S G+ L + Sbjct: 195 DFGESEYM----VDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVV 250 Query: 278 ALDHNRPAKEE--NLVDWARPYLTSKRKVLLIVDNR---LDTQYLPEEAVRMASVAVQCL 332 E N+ Y + L + N+ +L E + + L Sbjct: 251 PFSLKISLVELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLF---L 307 Query: 333 SFEPKSRPTMDQVVRA 348 P R T + ++ Sbjct: 308 RKNPAERITSEDALKH 323 >5UNP-A nrPDB Length = 369 Score = 144 bits (362), Expect = 9e-35, Method: Composition-based stats. Identities = 68/336 (20%), Positives = 117/336 (34%), Gaps = 72/336 (21%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT-EIN 123 + S +GEG FG V + G +A+K + + ++E EIN Sbjct: 34 ERYEIVSTLGEGTFGRVVQC--------VDHRRGGARVALKIIK--NVEKYKEAARLEIN 83 Query: 124 YLGQL-----SHPNL-VKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 L ++ + NL V++ + H + +E + L F + + P P Sbjct: 84 VLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLG---LSTFDFLKDNNYLPYPIHQV 140 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNIL-LDADYN------------------AKL 218 ++A + + FLH + K+ + D+K NIL +++DY ++ Sbjct: 141 RHMAFQLCQAVKFLHDN--KLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRV 198 Query: 219 SDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRA 278 DFG A + VS T Y APE + + DV+S G ++ E G Sbjct: 199 VDFGSATFDHEHHSTIVS-----TRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTL 253 Query: 279 LD-----HNRPAKEENLVDWARPYLTSKRKVLLIVDNRLD------------TQYLP--- 318 + E L + RK RLD P Sbjct: 254 FQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRR 313 Query: 319 ------EEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 EE ++ + L +EP R T+ + ++ Sbjct: 314 YLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQH 349 >3QD2-B nrPDB Length = 332 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 66/341 (19%), Positives = 120/341 (35%), Gaps = 81/341 (23%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTL-------------TPTKPGTGLVIAVKKLN---- 108 +F P +G GGFG VF+ + V A+ KL Sbjct: 7 DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGI 66 Query: 109 --------QEGFQGHREWLTEI------------------------NYLGQLSHPNLVKL 136 + + +E + EI + S N V Sbjct: 67 VRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVGQ 126 Query: 137 IGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPV 196 + + + + +K +L++ + RR + + +++ + A+ + FLHS Sbjct: 127 LQPSSPKVYLYIQMQLCRKENLKDWMNRR-CSLEDREHGVCLHIFIQIAEAVEFLHSK-- 183 Query: 197 KVIYRDIKASNILLDADYNAKLSDFGL--ARDGPMGDLSYVS--------TRVMGTYGYA 246 +++RD+K SNI D K+ DFGL A D + + ++ T +GT Y Sbjct: 184 GLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYM 243 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLL 306 +PE + + + + D++S G++L E+L + +T R + Sbjct: 244 SPEQIHGNNYSHKVDIFSLGLILFELL------------YSFSTQMERVRIITDVRNLKF 291 Query: 307 IVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 L TQ P+E + LS P RP ++ Sbjct: 292 ---PLLFTQKYPQE----HMMVQDMLSPSPTERPEATDIIE 325 >5GZA-A nrPDB Length = 290 Score = 141 bits (355), Expect = 5e-34, Method: Composition-based stats. Identities = 68/300 (22%), Positives = 118/300 (39%), Gaps = 43/300 (14%) Query: 68 RPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQ 127 R +IG+G V+ G +A+ L+ + Q ++L ++ L Sbjct: 28 RRVKLIGQGAVKKVYLSEW-----------QGQKVALSVLSSD--QYADDFLHGLSMLRA 74 Query: 128 LSHPNLVKLIGYCLEDEHRLLVYEFMQKGS---LENHLFRRGAYFKPLPWFLRVNVALDA 184 L ++V L+G C ED + V E+ GS L+ L + ++ W R+ +A+D Sbjct: 75 LQSSHVVTLVGVCEED--AVFVTEYHPLGSVLTLDTTLAQERYRWRN-SWHTRLQLAIDY 131 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPM--GDLSYVSTRVMGT 242 LA+LHS P + R + SN D + LS F LA D + DL + G Sbjct: 132 VAFLAYLHSSPAGI--RVMCDSN-----DLHKTLSQFLLASDMRLLANDLDALPEVEKGG 184 Query: 243 YGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKR 302 G + +G A ++ +G E S D P +E W P +T Sbjct: 185 LGVKCGHHELTGDFVAPEQLWPYG----EDFSFS---DEAMPGYDEKTDIWKIPDVTR-- 235 Query: 303 KVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQT 362 ++ + L + ++ S +C E RPT +V+ + + D++ + Sbjct: 236 ---FLLGDVLGGDVIHFHLFQIYS---ECKRKEAHMRPTAREVLSVYRSVYDSMMESQSQ 289 >3RAW-A nrPDB Length = 381 Score = 141 bits (355), Expect = 6e-34, Method: Composition-based stats. Identities = 60/336 (17%), Positives = 111/336 (33%), Gaps = 72/336 (21%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT-EIN 123 + +GEG FG V + +A+K + G +RE EIN Sbjct: 51 ERYEIVGNLGEGTFGKVVECL--------DHARGKSQVALKIIRNVG--KYREAARLEIN 100 Query: 124 YLGQL---SHPN---LVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 L ++ N V + + H + +E + + L + F+P P Sbjct: 101 VLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELL-GKNTFEFL--KENNFQPYPLPHV 157 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDA-------------------DYNAKL 218 ++A L FLH + + + D+K NIL + + ++ Sbjct: 158 RHMAYQLCHALRFLHENQ--LTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRV 215 Query: 219 SDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRA 278 +DFG A T ++ T Y PE + DV+S G +L E G Sbjct: 216 ADFGSATFDHEHH-----TTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTL 270 Query: 279 LDHNRPAKEENLVDWARPYLTSKRKV------------LLIVDNRLDTQYLPEEAV---- 322 + + +++ + S L+ +N D +Y+ E Sbjct: 271 FQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKS 330 Query: 323 ----------RMASVAVQCLSFEPKSRPTMDQVVRA 348 ++ + + L F+P R T+ + + Sbjct: 331 YMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLH 366 >3M42-A nrPDB Length = 299 Score = 140 bits (353), Expect = 9e-34, Method: Composition-based stats. Identities = 50/314 (15%), Positives = 101/314 (32%), Gaps = 64/314 (20%) Query: 65 RNFRP-DSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEIN 123 +++ V+G G G V L T A+K L Q + E+ Sbjct: 17 DDYKVTSQVLGLGINGKV---------LQIFNKRTQEKFALKML-----QDCPKARREVE 62 Query: 124 YL-GQLSHPNLVKLIGYCLE----DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRV 178 P++V+++ + L+V E + G L + + RG + Sbjct: 63 LHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRG--DQAFTEREAS 120 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDA---DYNAKLSDFGLARDGPMGDLSYV 235 + + + +LHS + + +RD+K N+L + + KL+DFG A++ Sbjct: 121 EIMKSIGEAIQYLHS--INIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT------- 171 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 + D++S GV++ +L G N Sbjct: 172 -----------------GEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP------ 208 Query: 296 PYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 + + + E + + + L EP R T+ + + +Q Sbjct: 209 ----GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ-- 262 Query: 356 LGKPSQTNPVKDTK 369 P+ ++ Sbjct: 263 -STKVPQTPLHTSR 275 >5VC6-A nrPDB Length = 289 Score = 135 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 61/309 (19%), Positives = 108/309 (34%), Gaps = 62/309 (20%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTE 121 T F IG G FG VFK K G + A+K+ + G + L E Sbjct: 10 TTEFHELEKIGSGEFGSVFKC---------VKRLDGCIYAIKRSKKPLAGSVDEQNALRE 60 Query: 122 INYLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 + L H ++V+ ED+H L+ E+ GSL + + ++ Sbjct: 61 VYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDL 120 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILL-------------DADYNA------KLSDF 221 L +GL ++HS + +++ DIK SNI + D D A K+ D Sbjct: 121 LLQVGRGLRYIHS--MSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDL 178 Query: 222 GLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLN--ARSDVYSFGVLLLEILSGKRAL 279 G + G + A E + ++D+++ + + +G L Sbjct: 179 GHVTRISSPQVEE------GDSRFLANEVLQEN-YTHLPKADIFALALTV-VCAAGAEPL 230 Query: 280 DHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSR 339 N ++ R+ Q L +E + V + +P+ R Sbjct: 231 PRNG---------------DQWHEIRQGRLPRI-PQVLSQEFTELLKVM---IHPDPERR 271 Query: 340 PTMDQVVRA 348 P+ +V+ Sbjct: 272 PSAMALVKH 280 >5VDK-A nrPDB Length = 297 Score = 132 bits (332), Expect = 2e-31, Method: Composition-based stats. Identities = 56/322 (17%), Positives = 105/322 (32%), Gaps = 65/322 (20%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE--GFQGHREWLTE 121 + F IG G FG V+K K G V A+K+ + L E Sbjct: 14 EKEFLEVEKIGVGEFGTVYKC---------IKRLDGCVYAIKRSMKTFTELSNENSALHE 64 Query: 122 INYLGQL-SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 + L HP++V+ ED+H ++ E+ GSL+ + ++ Sbjct: 65 VYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDI 124 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA-----------------------K 217 L + GL ++H+ + ++ DIK SNI + + K Sbjct: 125 LLQISLGLNYIHNSSM--VHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYK 182 Query: 218 LSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSG-HLNARSDVYSFGVLLLEILSGK 276 + D G A + G + A E + ++D+++ G+ + Sbjct: 183 IGDLGHATSINKPKVEE------GDSRFLANEILQEDYRHLPKADIFALGLTIA------ 230 Query: 277 RALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEP 336 V L + + E + +S+ + + Sbjct: 231 --------------VAAGAESLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDA 276 Query: 337 KSRPTMDQVVRALQQLQDNLGK 358 + RP+ + R L+ +LGK Sbjct: 277 EQRPSAAALARN-TVLRPSLGK 297 >5X1R-A nrPDB Length = 302 Score = 130 bits (328), Expect = 8e-31, Method: Composition-based stats. Identities = 57/311 (18%), Positives = 109/311 (35%), Gaps = 60/311 (19%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHRE------- 117 F IGEGGFG V++ + + T IA+K+ + Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERT---------IAIKEYMPTSLAKRNDDLSIGLR 71 Query: 118 --------------WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLF 163 ++ E L + SHP L+ ++ + E+ + +F +L+N Sbjct: 72 GERFGKTFQAGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNL-- 129 Query: 164 RRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGL 223 + + + + + +H + ++RDI NI + L DFG Sbjct: 130 -QAQQPEKIDEAWIRRLLPPLFSAINTIHQE--GYLHRDISLDNIQIQESQLPVLLDFGS 186 Query: 224 ARDGPMGDLSYVSTRVMGTYGYAAPEYM---SSGHLNARSDVYSFGVLLLEILSGKRALD 280 AR T ++ G+A E S G +D+Y+ G +L ++ G Sbjct: 187 ARKEIGNLSDE--TEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP-- 242 Query: 281 HNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP 340 P ++ + LT +R + + + L+ +P+ RP Sbjct: 243 ---PVSVVRSIEDSYQPLTERR--------------PAGYSPELLRTVDRALALKPEDRP 285 Query: 341 -TMDQVVRALQ 350 T+D++ L+ Sbjct: 286 QTIDEMAELLE 296 >3LLT-A nrPDB Length = 360 Score = 129 bits (325), Expect = 1e-30, Method: Composition-based stats. Identities = 62/369 (16%), Positives = 120/369 (32%), Gaps = 78/369 (21%) Query: 38 AAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPG 97 ++ + + F++ + L F +G+G FG V Sbjct: 8 SSGRENLYFQGDDEIVHFSWKKGMLLNNAFLVIRKMGDGTFGRVLLCQ---------HID 58 Query: 98 TGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNL-----VKLIGYCLEDEHRLLVYEF 152 AVK + + R E + L ++ + ++ VK G + +H L++E Sbjct: 59 NKKYYAVKVVRNIK-KYTRSAKIEADILKKIQNDDINNNNIVKYHGKFMYYDHMCLIFEP 117 Query: 153 MQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDA 212 + SL + R + ++ K L +L + + + D+K NILLD Sbjct: 118 L-GPSLYEIITRNNYNGFHIE--DIKLYCIEILKALNYL--RKMSLTHTDLKPENILLDD 172 Query: 213 DY-------------------------NAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAA 247 Y KL DFG A S ++ T Y A Sbjct: 173 PYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATF-----KSDYHGSIINTRQYRA 227 Query: 248 PEYMSSGHLNARSDVYSFGVLLLEILSGKRAL-DHNRPAKEENLVDWARPYLTSK----- 301 PE + + + SD++SFG +L E+ +G H + +P + Sbjct: 228 PEVILNLGWDVSSDMWSFGCVLAELYTGSLLFRTHEHMEHLAMMESIIQPIPKNMLYEAT 287 Query: 302 --RKVLLIVDNRLDTQYLP-----------EEAVRMASVAVQ---C------LSFEPKSR 339 + + L + ++ + + + C L +P R Sbjct: 288 KTNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYKIIKHELFCDFLYSILQIDPTLR 347 Query: 340 PTMDQVVRA 348 P+ ++++ Sbjct: 348 PSPAELLKH 356 >4WUA-A nrPDB Length = 401 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 60/374 (16%), Positives = 112/374 (29%), Gaps = 110/374 (29%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 + +G G F V+ W + +A+K + + L EI L Sbjct: 42 RYHVIRKLGWGHFSTVWLSWDIQG---------KKFVAMKVV-KSAEHYTETALDEIRLL 91 Query: 126 GQLSH-----PN---LVKLIGYC----LEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLP 173 + + PN +V+L+ + H +V+E + L + + PLP Sbjct: 92 KSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGH-HLLKWIIKSNYQGLPLP 150 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLD---------------------- 211 + +GL +LH+ ++I+ DIK NILL Sbjct: 151 CV--KKIIQQVLQGLDYLHTKC-RIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAP 207 Query: 212 ---------------------------ADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYG 244 K++D G A + T + T Sbjct: 208 PPSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACW-----VHKHFTEDIQTRQ 262 Query: 245 YAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNR--------------------- 283 Y + E + N +D++S + E+ +G + + Sbjct: 263 YRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKV 322 Query: 284 PAKEENLVDWARPYLTSKRKVLLIVDNRLDT---------QYLPEEAVRMASVAVQCLSF 334 P K +++ + T K + I + ++ EEA + L Sbjct: 323 PRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLEL 382 Query: 335 EPKSRPTMDQVVRA 348 P+ R T + +R Sbjct: 383 IPEKRATAAECLRH 396 >2JD5-A nrPDB Length = 373 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 54/356 (15%), Positives = 118/356 (33%), Gaps = 71/356 (19%) Query: 63 ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEI 122 + +G G F V+ +A+K + + EI Sbjct: 17 KDARYILVRKLGWGHFSTVWLA---------KDMVNNTHVAMKIVRGDKV-YTEAAEDEI 66 Query: 123 NYLGQLSHP-----------NLVKLIGYCLEDE----HRLLVYEFMQKGSLENHLFRRGA 167 L +++ +++KL+ + H ++V+E + +L + + Sbjct: 67 KLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVL-GENLLALIKK--Y 123 Query: 168 YFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLD------ADYNAKLSDF 221 + +P ++ GL ++H +I+ DIK N+L++ K++D Sbjct: 124 EHRGIPLIYVKQISKQLLLGLDYMHRRC-GIIHTDIKPENVLMEIVDSPENLIQIKIADL 182 Query: 222 GLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDH 281 G A T + T Y +PE + +D++S L+ E+++G + Sbjct: 183 GNACW-----YDEHYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEP 237 Query: 282 N---------------------RPAKEENLVDWARPYLTSKRKVLLIVDNRLDT------ 314 + P+ + R + S+ + I + Sbjct: 238 DEGHSYTKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLT 297 Query: 315 ---QYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVKD 367 ++ +EA ++ L +P+ R +V L+D LG P ++ Sbjct: 298 EKYKFSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPW-LKDTLGMEEIRVPDRE 352 >2X7G-A nrPDB Length = 389 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 56/372 (15%), Positives = 114/372 (30%), Gaps = 108/372 (29%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 + +G G F V+ W + +A+K + + L EI L Sbjct: 32 RYHVIRKLGWGHFSTVWLCWDMQG---------KRFVAMKVV-KSAQHYTETALDEIKLL 81 Query: 126 GQLS-----HPN---LVKLIGYC----LEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLP 173 + PN +V+LI + H +V+E + L + + + ++ LP Sbjct: 82 KCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGH-HLLKWIIK--SNYQGLP 138 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILL----------------------- 210 ++ +GL +LHS K+I+ DIK NIL+ Sbjct: 139 VRCVKSIIRQVLQGLDYLHSKC-KIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAP 197 Query: 211 ------------------------DADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYA 246 K++D G A + T + T Y Sbjct: 198 PPSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACW-----VHKHFTEDIQTRQYR 252 Query: 247 APEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVD-------------- 292 + E + + +D++S + E+ +G + + D Sbjct: 253 SIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPR 312 Query: 293 -------WARPYLTSKRKVLLIVDNRLDT---------QYLPEEAVRMASVAVQCLSFEP 336 ++R + + ++ I + + + E+A + + L P Sbjct: 313 HFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVP 372 Query: 337 KSRPTMDQVVRA 348 + R + + +R Sbjct: 373 EKRASAGECLRH 384 >4MD7-E nrPDB Length = 391 Score = 122 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 50/343 (14%), Positives = 116/343 (33%), Gaps = 50/343 (14%) Query: 33 SSTVAAAQKTEGEILSSTPVKSFTFNE--LKLA-TRNFRPDSVIGEGGFGCVFKGWLDES 89 S V + + ++ + P + + + ++ +++ +G G + VF+ + Sbjct: 2 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITN 61 Query: 90 TLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRL-- 147 V + + + + L PN++ L + R Sbjct: 62 NEKVVVKILKPV---------KKKKIKREIKILENLRGG--PNIITLADIVKDPVSRTPA 110 Query: 148 LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASN 207 LV+E + + ++ L + + K L + HS + +++RD+K N Sbjct: 111 LVFEHVNNTDFKQ-------LYQTLTDYDIRFYMYEILKALDYCHS--MGIMHRDVKPHN 161 Query: 208 ILLD-ADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM-SSGHLNARSDVYSF 265 +++D +L D+GLA G V + + + PE + + D++S Sbjct: 162 VMIDHEHRKLRLIDWGLAEFYHPGQEYNVR---VASRYFKGPELLVDYQMYDYSLDMWSL 218 Query: 266 GVLLLEILSGKRALDHNRPAKE-----------ENLVDWARPYLTS---------KRKVL 305 G +L ++ K H + E+L D+ Y R Sbjct: 219 GCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSR 278 Query: 306 LIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + ++ + + L ++ +SR T + + Sbjct: 279 KRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321 >6HMD-A nrPDB Length = 365 Score = 120 bits (301), Expect = 1e-27, Method: Composition-based stats. Identities = 47/330 (14%), Positives = 112/330 (33%), Gaps = 49/330 (14%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 +++ +G G + VF+ + V + + + + Sbjct: 53 DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV---------KKKKIKREVKILEN 103 Query: 125 LGQLSHPNLVKLIGYCLEDEHRL--LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 L + N++KLI + + LV+E++ + ++ L F Sbjct: 104 LRGGT--NIIKLIDTVKDPVSKTPALVFEYINNTDFKQ-------LYQILTDFDIRFYMY 154 Query: 183 DAAKGLAFLHSDPVKVIYRDIKASNILLD-ADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 + K L + HS +++RD+K N+++D +L D+GLA V + Sbjct: 155 ELLKALDYCHSK--GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR---VA 209 Query: 242 TYGYAAPEYM-SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENL-------VDW 293 + + PE + + D++S G +L ++ + H + ++ + + Sbjct: 210 SRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEE 269 Query: 294 ARPYLTS-------------KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRP 340 YL + +N + ++ + + + L ++ + R Sbjct: 270 LYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRL 329 Query: 341 TMDQVVRA--LQQLQDNLGKPSQTNPVKDT 368 T + + + +PS N V + Sbjct: 330 TAKEAMEHPYFYPVVKEQSQPSADNAVLSS 359 >5XVU-A nrPDB Length = 332 Score = 120 bits (300), Expect = 1e-27, Method: Composition-based stats. Identities = 52/336 (15%), Positives = 111/336 (33%), Gaps = 50/336 (14%) Query: 40 QKTEGEILSSTPVKSFTFNELKL---ATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKP 96 K ++ P + + ++ L+L + IG G + VF G+ E Sbjct: 3 PKFYADVNIHKPKEYYDYDNLELQWNKPNRYEIMKKIGRGKYSEVFNGYDTEC------- 55 Query: 97 GTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRL--LVYEFMQ 154 A+K L + + + + L PN++KL+ + + L++E++ Sbjct: 56 --NRPCAIKVLKPVKKKKIKREIKILQNLNGG--PNIIKLLDIVKDPVTKTPSLIFEYIN 111 Query: 155 KGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLD-AD 213 + K L + HS +++RD+K NI++D + Sbjct: 112 N-------IDFKTLYPKFTDKDIRYYIYQILKALDYCHSQ--GIMHRDVKPHNIMIDHEN 162 Query: 214 YNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSS-GHLNARSDVYSFGVLLLEI 272 +L +GLA G V + + Y PE + + D++S G +L + Sbjct: 163 RQIRLISWGLAEFYHPGQEYNVR---VASRYYKGPELLIDLQLYDYSLDIWSLGCMLAGM 219 Query: 273 LSGKRALDHNRPAKE-----------ENLVDWARPYLTSKRKVLLIV---------DNRL 312 + K + E+L + + Y + L + + L Sbjct: 220 IFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFL 279 Query: 313 DTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + + + L ++ R + + Sbjct: 280 TQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEH 315 >2PVN-A nrPDB Length = 352 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 51/346 (14%), Positives = 116/346 (33%), Gaps = 52/346 (15%) Query: 30 RKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLA---TRNFRPDSVIGEGGFGCVFKGWL 86 + S A + +L P + + + L + ++ +G G + VF+G Sbjct: 16 PRGSHMSKARVYADVNVL--RPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGIN 73 Query: 87 DESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHR 146 + V + + + + L PN+VKL+ + + Sbjct: 74 VNNNEKCIIKILKPV---------KKKKIKREIKILQNL--CGGPNIVKLLDIVRDQHSK 122 Query: 147 L--LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIK 204 L++E++ + + L + + K L + HS +++RD+K Sbjct: 123 TPSLIFEYVNNTDFK-------VLYPTLTDYDIRYYIYELLKALDYCHSQ--GIMHRDVK 173 Query: 205 ASNILLDADY-NAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSS-GHLNARSDV 262 N+++D + +L D+GLA G V + + + PE + + D+ Sbjct: 174 PHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVR---VASRYFKGPELLVDLQDYDYSLDM 230 Query: 263 YSFGVLLLEILSGKRALDHNRPAKEENLV-------DWARPYLTSKR-----KVLLIVDN 310 +S G + ++ K + ++ + D YL R ++ +V Sbjct: 231 WSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELDPQLEALVGR 290 Query: 311 RLDTQYLPEE--------AVRMASVAVQCLSFEPKSRPTMDQVVRA 348 +L + + L ++ + R T + + Sbjct: 291 HSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTH 336 >6EII-A nrPDB Length = 352 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 49/341 (14%), Positives = 115/341 (33%), Gaps = 50/341 (14%) Query: 35 TVAAAQKTEGEILSSTPVKSFTFNE--LKLA-TRNFRPDSVIGEGGFGCVFKGWLDESTL 91 V + + ++ + P + + + ++ +++ +G G + VF+ + Sbjct: 27 PVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNE 86 Query: 92 TPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRL--LV 149 V + + + + L PN++ L + R LV Sbjct: 87 KVVVKILKPV---------KKKKIKREIKILENLRGG--PNIITLADIVKDPVSRTPALV 135 Query: 150 YEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNIL 209 +E + + ++ L + + K L + HS + +++RD+K N++ Sbjct: 136 FEHVNNTDFKQ-------LYQTLTDYDIRFYMYEILKALDYCHS--MGIMHRDVKPHNVM 186 Query: 210 LD-ADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM-SSGHLNARSDVYSFGV 267 +D +L D+GLA G V + + + PE + + D++S G Sbjct: 187 IDHEHRKLRLIDWGLAEFYHPGQEYNVR---VASRYFKGPELLVDYQMYDYSLDMWSLGC 243 Query: 268 LLLEILSGKRALDHNRPAKE-----------ENLVDWARPYLTS---------KRKVLLI 307 +L ++ K H + E+L D+ Y R Sbjct: 244 MLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKR 303 Query: 308 VDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + ++ + + L ++ +SR T + + Sbjct: 304 WERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 344 >4F9B-A nrPDB Length = 361 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 58/344 (16%), Positives = 108/344 (31%), Gaps = 84/344 (24%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLG 126 F+ + IGEG F V+ + G IA+K L I Sbjct: 23 FKIEDKIGEGTFSSVYLAT------AQLQVGPEEKIALKHLIPTSHP--------IRIAA 68 Query: 127 QLSH-------PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVN 179 +L N++ + +++H ++ +++ S + L L + Sbjct: 69 ELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNS-------LSFQEVRE 121 Query: 180 VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAK-LSDFGLARDGPMGDLSYVS-- 236 L+ K L +H +++RD+K SN L + L DFGLA+ + + Sbjct: 122 YMLNLFKALKRIHQ--FGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFV 179 Query: 237 ------------------------TRVMGTYGYAAPEYMSSGHL-NARSDVYSFGVLLLE 271 GT G+ APE ++ D++S GV+ L Sbjct: 180 QSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLS 239 Query: 272 ILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQC 331 +LSG+ A ++ + R+ + + +E Sbjct: 240 LLSGRYPFYK---ASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVP--------- 287 Query: 332 LSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVKDTKKLGFKT 375 + L++L + L + P + G T Sbjct: 288 --------------AQDLRKLCERLRGMDSSTPKLTSDIQGHAT 317 >4LFI-A nrPDB Length = 374 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 48/342 (14%), Positives = 113/342 (33%), Gaps = 65/342 (19%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAV-------------- 104 + T+++ ++ +G G + VF+G +S + V Sbjct: 34 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSN 93 Query: 105 KKLNQEGFQGHREW----LTEINYLGQLS----------HPNLVKLIGYCLEDEHRL--L 148 +K+ ++ E + L + H N++ L + + L Sbjct: 94 EKVPPTTLPFQKDQYYTNQKE-DVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 152 Query: 149 VYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNI 208 V+E++ + L + K L + HS + +++RD+K N+ Sbjct: 153 VFEYVDNVDF-------RILYPKLTDLEIRFYMFELLKALDYCHS--MGIMHRDVKPHNV 203 Query: 209 LLDA-DYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM-SSGHLNARSDVYSFG 266 ++D + +L D+GLA + V + + + PE + + D++SFG Sbjct: 204 MIDHKNKKLRLIDWGLAEFYHVNMEYNVR---VASRFFKGPELLVDYRMYDYSLDLWSFG 260 Query: 267 VLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAV---- 322 +L ++ + H ++ + + K LL + L ++ + Sbjct: 261 TMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKP 320 Query: 323 ----------------RMASVAVQCLSFEPKSRPTMDQVVRA 348 + + L ++ + R T + + Sbjct: 321 WHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGH 362 >5M07-A nrPDB Length = 276 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 47/273 (17%), Positives = 93/273 (34%), Gaps = 40/273 (14%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQE---GFQGHREWLTEIN 123 + ++G G V+ A+K L+ + R + E Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQ---------ALKVLSPAMAADDEFRRRFQRETE 82 Query: 124 YLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 +L HP+++++ D + +++ H+ R + LP + + Sbjct: 83 VAARLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADR--FPAVLPVGEVLAIVTA 140 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDA----DYNAKLSDFGLARDGPMGDLSYVSTRV 239 A L + H +++RD+ +N++L + D L+DFG+A Sbjct: 141 VAGALDYAHQR--GLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ------------- 185 Query: 240 MGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALD--HNRPAKEENLVDWARPY 297 Y APE + ++ R+D Y+ + + + +G +D H P + L + RP Sbjct: 186 ---PSYPAPELSAGADVDGRADQYALALTAIHLFAGAPPVDRSHTGPLQPPKLSAF-RPD 241 Query: 298 LTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQ 330 L VL A + Sbjct: 242 LARLDGVLSRALATAPADRF-GSCREFADAMNE 273 >5L2Q-C nrPDB Length = 320 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 52/305 (17%), Positives = 99/305 (32%), Gaps = 58/305 (19%) Query: 89 STLTPTKPGTGLVIAVKKL-----------NQEGFQGHREWLTEINYLGQLSHPN-LVKL 136 K GT +K L +QE QG TE + L L + +V Sbjct: 31 VQCLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHH 90 Query: 137 IGYCLE------------------DEHRLLVYEFMQKGSLENH------LFRRGAYFKPL 172 G + + LV + + + L K L Sbjct: 91 HGLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRL 150 Query: 173 PWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYN-AKLSDFGLARDGPMGD 231 V + D + + LH +++RD+K N++L+ + +++F L + Sbjct: 151 SERETVVIFYDVVRVVEALHQK--NIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEG 208 Query: 232 LSYVSTRVMGTYGYAAPEYMSSGHL-NARSDVYSFGVLLLEILSGKRALDHNRPAKEENL 290 R G+ Y +P+ +S SD+++ GV+L +L G+ + P + Sbjct: 209 DLLKDQR--GSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRK 266 Query: 291 VDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQ 350 + A + +V + + L +P+ R V+ AL Sbjct: 267 IKAAEYTIPEDGRVSENTVC----------------LIRKLLVLDPQQRLAAADVLEALS 310 Query: 351 QLQDN 355 + + Sbjct: 311 AIIAS 315 >4NFN-A nrPDB Length = 309 Score = 105 bits (261), Expect = 5e-23, Method: Composition-based stats. Identities = 46/247 (18%), Positives = 90/247 (36%), Gaps = 25/247 (10%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTE 121 + ++ IG GGFG +++ T +A+K + Q + E Sbjct: 18 VVKDRWKVLKKIGGGGFGEIYEA---------MDLLTRENVALKV--ESAQQPKQVLKME 66 Query: 122 INYLGQLS-HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 + L +L ++ + IG ++ +V + +Q +L + RR + + Sbjct: 67 VAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQ-LQGRNLAD--LRRSQPRGTFTLSTTLRL 123 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNI----LLDADYNAKLSDFGLARDGPMGDLSYVS 236 + + +HS V ++RDIK SN L + DFGLAR Sbjct: 124 GKQILESIEAIHS--VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRP 181 Query: 237 TR----VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVD 292 R GT YA+ + + D++S +L+E G+ + ++ ++ Sbjct: 182 PRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIK 241 Query: 293 WARPYLT 299 + Sbjct: 242 EKYEHRM 248 >4BTK-A nrPDB Length = 337 Score = 105 bits (261), Expect = 5e-23, Method: Composition-based stats. Identities = 46/247 (18%), Positives = 90/247 (36%), Gaps = 25/247 (10%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTE 121 + ++ IG GGFG +++ T +A+K + Q + E Sbjct: 53 VVKDRWKVLKKIGGGGFGEIYEA---------MDLLTRENVALKV--ESAQQPKQVLKME 101 Query: 122 INYLGQLS-HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNV 180 + L +L ++ + IG ++ +V + +Q +L + RR + + Sbjct: 102 VAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQ-LQGRNLAD--LRRSQPRGTFTLSTTLRL 158 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNI----LLDADYNAKLSDFGLARDGPMGDLSYVS 236 + + +HS V ++RDIK SN L + DFGLAR Sbjct: 159 GKQILESIEAIHS--VGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRP 216 Query: 237 TR----VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVD 292 R GT YA+ + + D++S +L+E G+ + ++ ++ Sbjct: 217 PRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIK 276 Query: 293 WARPYLT 299 + Sbjct: 277 EKYEHRM 283 >6DC0-A nrPDB Length = 292 Score = 101 bits (252), Expect = 5e-22, Method: Composition-based stats. Identities = 34/222 (15%), Positives = 77/222 (34%), Gaps = 27/222 (12%) Query: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 SH N+ ++ L + + +E G + +++ R + + + Sbjct: 56 SHSNITGIVEVILGETKAYVFFEK-DFGDMHSYVRSRKRLREEEA----ARLFKQIVSAV 110 Query: 189 AFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAP 248 A H ++ D+K + + +L L M + G Y +P Sbjct: 111 AHCHQSA--IVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSP 168 Query: 249 EYMSS-GHLNARS-DVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLL 306 E +++ G + ++ DV+S GV+L +L G+ + P+ + R+ Sbjct: 169 EILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSAL----------FSKIRRGQF 218 Query: 307 IVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + + + + L EP R T +++ Sbjct: 219 CIPEHI--------SPKARCLIRSLLRREPSERLTAPEILLH 252 >5CEK-A nrPDB Length = 263 Score = 101 bits (251), Expect = 6e-22, Method: Composition-based stats. Identities = 34/222 (15%), Positives = 77/222 (34%), Gaps = 27/222 (12%) Query: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 SH N+ ++ L + + +E G + +++ R + + + Sbjct: 59 SHSNITGIVEVILGETKAYVFFEK-DFGDMHSYVRSRKRLREEEA----ARLFKQIVSAV 113 Query: 189 AFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAP 248 A H ++ D+K + + +L L M + G Y +P Sbjct: 114 AHCHQSA--IVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSP 171 Query: 249 EYMSS-GHLNARS-DVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLL 306 E +++ G + ++ DV+S GV+L +L G+ + P+ + R+ Sbjct: 172 EILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSAL----------FSKIRRGQF 221 Query: 307 IVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA 348 + + + + + L EP R T +++ Sbjct: 222 CIPEHI--------SPKARCLIRSLLRREPSERLTAPEILLH 255 >2PZI-A nrPDB Length = 681 Score = 99.8 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 56/290 (19%), Positives = 105/290 (36%), Gaps = 46/290 (15%) Query: 56 TFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEG---- 111 N + + I GG G ++ G + +K L G Sbjct: 71 QLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNV--------NGRPVVLKGLVHSGDAEA 122 Query: 112 ---FQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHR-----LLVYEFMQKGSLENHLF 163 R++L E+ HP++V++ + + +V E++ SL Sbjct: 123 QAMAMAERQFLAEVV------HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL----- 171 Query: 164 RRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGL 223 + + + LP + L+ L++LHS + ++Y D+K NI+L + KL D G Sbjct: 172 -KRSKGQKLPVAEAIAYLLEILPALSYLHS--IGLVYNDLKPENIMLTEE-QLKLIDLGA 227 Query: 224 ARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNR 283 Y GT G+ APE + +G +D+Y+ G L L+ + R Sbjct: 228 VSRINSFGYLY------GTPGFQAPEIVRTGP-TVATDIYTVGRTLAA-LTLDLPTRNGR 279 Query: 284 PAKEENLVDWA-RPYLTSKRKVLLIVDNRLDTQY--LPEEAVRMASVAVQ 330 D + Y + R + +D ++ E + ++ V + Sbjct: 280 YVDGLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQLTGVLRE 329 >4Y12-A nrPDB Length = 375 Score = 99.8 bits (247), Expect = 2e-21, Method: Composition-based stats. Identities = 56/290 (19%), Positives = 105/290 (36%), Gaps = 46/290 (15%) Query: 56 TFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEG---- 111 N + + I GG G ++ G + +K L G Sbjct: 110 QLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNV--------NGRPVVLKGLVHSGDAEA 161 Query: 112 ---FQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHR-----LLVYEFMQKGSLENHLF 163 R++L E+ HP++V++ + + +V E++ SL Sbjct: 162 QAMAMAERQFLAEVV------HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL----- 210 Query: 164 RRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGL 223 + + + LP + L+ L++LHS + ++Y D+K NI+L + KL D G Sbjct: 211 -KRSKGQKLPVAEAIAYLLEILPALSYLHS--IGLVYNDLKPENIMLTEE-QLKLIDLGA 266 Query: 224 ARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNR 283 Y GT G+ APE + +G +D+Y+ G L L+ + R Sbjct: 267 VSRINSFGYLY------GTPGFQAPEIVRTGP-TVATDIYTVGRTLAA-LTLDLPTRNGR 318 Query: 284 PAKEENLVDWA-RPYLTSKRKVLLIVDNRLDTQY--LPEEAVRMASVAVQ 330 D + Y + R + +D ++ E + ++ V + Sbjct: 319 YVDGLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQLTGVLRE 368 >5OAT-A nrPDB Length = 411 Score = 97.9 bits (242), Expect = 7e-21, Method: Composition-based stats. Identities = 58/357 (16%), Positives = 109/357 (30%), Gaps = 69/357 (19%) Query: 57 FNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR 116 F + + I +G G V+ + + K A+K + Q + Sbjct: 3 FESNPITLNDLSLGKPIAKGTNGVVYSAKVKDDETDDNK----YPFALKMMFNYDIQENS 58 Query: 117 -EWLT---------------------EINYLGQLSH----PNLVKLIGYCLEDEHRLLVY 150 E L EI + H PN+V + + L Sbjct: 59 MEILKAMYRETVPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPP 118 Query: 151 EFMQKG-----SLENHLFRRGAYFKPL-----PWFLRVNVALDAAKGLAFLHSDPVKVIY 200 +G SL + R + + + +G+A + + + + Sbjct: 119 RLHPEGEGRNMSLFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQLLEGVAHMTAH--GIAH 176 Query: 201 RDIKASNILLD----ADYNAKLSDFGLARDGPMGDLSYVSTRVM----GTYGYAAPEYMS 252 RD+K+ N+LLD +SDFG LS T G APE + Sbjct: 177 RDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIIC 236 Query: 253 SGHLN------ARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRK--- 303 +++D+++ G + EI + K N + P L + Sbjct: 237 QKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEVPTVI 296 Query: 304 ---VLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPK-----SRPTMDQVVRALQQL 352 V ++ + + PE A + + + + PT ++++ L L Sbjct: 297 QALVANLLKRNPNKRLDPEVAANVCQLFL--WAPSTWLKPGLKVPTSGEILQWLLSL 351 >3SV0-A nrPDB Length = 483 Score = 92.8 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 53/231 (22%), Positives = 82/231 (35%), Gaps = 36/231 (15%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 FR IG G FG ++ G T T +A+K + H + L E Sbjct: 7 NKFRLGRKIGSGSFGEIYLG---------TNIQTNEEVAIK--LENVKTKHPQLLYESKI 55 Query: 125 LGQLSH----PNLVKLIGYCLEDEHRLLVYEFM--QKGSLENHLFRRGAYFKPLPWFLRV 178 L PN V+ G E ++ +LV + + L N R+ L + Sbjct: 56 YRILQGGTGIPN-VRWFGV--EGDYNVLVMDLLGPSLEDLFNFCSRK------LSLKTVL 106 Query: 179 NVALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD---YNAKLSDFGLARDGPMGDLSYV 235 +A + F+HS ++RDIK N L+ + DFGLA+ Sbjct: 107 MLADQMINRVEFVHSKS--FLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQH 164 Query: 236 -----STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDH 281 + + GT YA+ + R D+ S G +L+ L G Sbjct: 165 IPYRENKNLTGTARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQG 215 >5X18-A nrPDB Length = 295 Score = 92.5 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 51/227 (22%), Positives = 81/227 (35%), Gaps = 28/227 (12%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVK-KLNQEGFQGHREWLTEINY 124 +++ IGEG FG +F+G T G+ +A+K + + R+ Sbjct: 8 HYKIGKKIGEGSFGVLFEG---------TNMINGVPVAIKFEPRKTEAPQLRDEYKTYKI 58 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 L PN+ + E H +LV + + SLE+ G F V VA+ Sbjct: 59 LNGT--PNIPYAYYFGQEGLHNILVIDLL-GPSLEDLFDWCGRKF---SVKTVVQVAVQM 112 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADYN-----AKLSDFGLARDGPMGDL-----SY 234 + LH+ +IYRDIK N L+ L DFG+A+ Sbjct: 113 ITLIEDLHAHD--LIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYR 170 Query: 235 VSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDH 281 + GT Y + + R D+ + G + L G Sbjct: 171 EKKSLSGTARYMSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQG 217 >5GZ9-A nrPDB Length = 305 Score = 90.5 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 61/304 (20%), Positives = 108/304 (35%), Gaps = 62/304 (20%) Query: 68 RPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQ 127 R +GEG VF E +A+ +L + + ++L + L Sbjct: 37 RQLKRVGEGAVKRVFLSEWKEH-----------KVALSRLTR--LEMKEDFLHGLQMLKS 83 Query: 128 LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLEN--HLFRRGAYFKPLPWFLRVNVALDAA 185 L ++V L+GYC ED ++ E+ GSL N + Y W R+ +A++ Sbjct: 84 LQSEHVVTLVGYCEEDG--TILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYV 141 Query: 186 KGLAFLHSDPVKVIYRDIKASN--------ILLDADYNAKLSDFGLARDGPMGDLSYVST 237 + +LH P+ R + SN LL ++++ +D P+ D Sbjct: 142 SIINYLHHSPLGT--RVMCDSNDLPKTLSQYLLTSNFSIVANDL---DALPLVDHDSGVL 196 Query: 238 RVMGTYG----YAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRAL-DHNRPAKEENLVD 292 G + APE + + +G E D P+ E + Sbjct: 197 IKCGHRELHGDFVAPEQL-----------WPYG----E----DTPFQDDLMPSYNEKVDI 237 Query: 293 WARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 W P ++S + + + + + C S P RPT V+ A Q++ Sbjct: 238 WKIPDVSSFLLGHVEGSDMVR--------FHLFDIHKACKSQIPAERPTAQNVLDAYQRV 289 Query: 353 QDNL 356 +L Sbjct: 290 FHSL 293 >5FQD-C nrPDB Length = 341 Score = 90.1 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 47/219 (21%), Positives = 77/219 (35%), Gaps = 37/219 (16%) Query: 67 FRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLG 126 ++ IG G FG ++ G +AVK + H + L E Sbjct: 21 YKLVRKIGSGSFGDIYLA---------INITNGEEVAVK--LESQKARHPQLLYESKLYK 69 Query: 127 QLSH----PNLVKLIGYCLEDEHRLLVYEFM--QKGSLENHLFRRGAYFKPLPWFLRVNV 180 L P++ + G E ++ +LV + + L N RR + + Sbjct: 70 ILQGGVGIPHI-RWYG--QEKDYNVLVMDLLGPSLEDLFNFCSRR------FTMKTVLML 120 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAK---LSDFGLARDGPMGDL----- 232 A + ++H+ I+RDIK N L+ + L DFGLA+ Sbjct: 121 ADQMISRIEYVHTK--NFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIP 178 Query: 233 SYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFG-VLLL 270 + GT YA+ + R D+ S G VL+ Sbjct: 179 YREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMY 217 >4TN6-A nrPDB Length = 318 Score = 89.8 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 57/310 (18%), Positives = 101/310 (32%), Gaps = 41/310 (13%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW 118 EL++ +R IG G FG ++ G T G +A+K + H + Sbjct: 2 ELRVG-NRYRLGRKIGSGSFGDIYLG---------TDIAAGEEVAIK--LECVKTKHPQL 49 Query: 119 LTEINYLGQLSHPNLVKLIGYC-LEDEHRLLVYEFM--QKGSLENHLFRRGAYFKPLPWF 175 E + + I +C E ++ ++V E + L N R+ Sbjct: 50 HIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRK------FSLK 103 Query: 176 LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILL---DADYNAKLSDFGLARDGPMGDL 232 + +A + ++HS I+RD+K N L+ + DFGLA+ Sbjct: 104 TVLLLADQMISRIEYIHSK--NFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDART 161 Query: 233 SYV-----STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE 287 + + GT YA+ + R D+ S G ++ + P + Sbjct: 162 HQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLG---YVLMYFNL---GSLPWQG 215 Query: 288 ENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVR 347 + Y K + L Y E A+ C S +P + + Sbjct: 216 LKAATKRQKYERISEKKMSTPIEVLCKGYPSE----FATYLNFCRSLRFDDKPDYSYLRQ 271 Query: 348 ALQQLQDNLG 357 + L G Sbjct: 272 LFRNLFHRQG 281 >4XHH-A nrPDB Length = 403 Score = 85.9 bits (211), Expect = 2e-17, Method: Composition-based stats. Identities = 56/307 (18%), Positives = 100/307 (32%), Gaps = 42/307 (13%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT-EIN 123 R FR IG G FG ++ G T +G +A+ E + L E Sbjct: 7 RKFRIGRKIGSGSFGDIYHG---------TNLISGEEVAI---RLESIRSRHPQLDYESR 54 Query: 124 YLGQLSHPNLVKLIGYC-LEDEHRLLVYEFM--QKGSLENHLFRRGAYFKPLPWFLRVNV 180 LS + I + E E+ +V + + L N+ R+ + + + Sbjct: 55 VYKYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRK------FSFKTVIML 108 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLD---ADYNAKLSDFGLARDGPMGDLSYV-- 235 AL + ++H I+RDIK N L+ + DFGL++ + Sbjct: 109 ALQMICRVQYIH--GRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIP 166 Query: 236 ---STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVD 292 + + GT YA+ + R D+ S G +L+ G + ++ D Sbjct: 167 YRENKSLTGTARYASVNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYD 226 Query: 293 WARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 ++L + + C + + RP + R + L Sbjct: 227 ----------RILEKKLCISVETLCAGLPLEFSEYMNYCRNLKFDERPDYLYLARLFKDL 276 Query: 353 QDNLGKP 359 L Sbjct: 277 SIKLEYH 283 >2C47-A nrPDB Length = 313 Score = 85.1 bits (209), Expect = 4e-17, Method: Composition-based stats. Identities = 54/276 (19%), Positives = 98/276 (35%), Gaps = 35/276 (12%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 NFR IG G FG + G T +A+K L + + L E + Sbjct: 5 NFRVGKKIGCGNFGELRLG---------KNLYTNEYVAIK-LEPIKSRAPQLHL-EYRFY 53 Query: 126 GQLS-HPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 QLS + ++ + ++ +V E + SLE+ F + +A+ Sbjct: 54 KQLSATEGVPQVYYFGPCGKYNAMVLELL-GPSLEDLFDLCDRTF---TLKTVLMIAIQL 109 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADYNAK-----LSDFGLARDGPMGDLSYV---- 235 + ++H+ +IYRD+K N L+ + + DFGLA++ + Sbjct: 110 ITRMEYVHTKS--LIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYR 167 Query: 236 -STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWA 294 + GT Y + + R D+ + G + + L G K + L + Sbjct: 168 EHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG---LKADTLKERY 224 Query: 295 RPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQ 330 + +KR + V + PEE + Sbjct: 225 QKIGDTKRATPIEVL----CENFPEEMATYLRYVRR 256 >6EQI-C nrPDB Length = 433 Score = 85.1 bits (209), Expect = 5e-17, Method: Composition-based stats. Identities = 47/342 (13%), Positives = 95/342 (27%), Gaps = 96/342 (28%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWL----- 119 I +G V+ L +AVK + + + + Sbjct: 15 DELDLGEPIAKGCNAVVYSAKLKNVQSNKL----AHQLAVKMMFNYDVESNSTAILKAMY 70 Query: 120 TE---------------INYLGQLS-----HPNLVKLIGYCLE----------------- 142 E I + HPN+V++ + Sbjct: 71 RETVPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALP 130 Query: 143 ----------DEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 + LV + +L+ +L + + L + +A H Sbjct: 131 PRINPEGSGRNMSLFLVMKRYDC-TLKEYLRDKTPNMRSSILLLSQL-----LEAVA--H 182 Query: 193 SDPVKVIYRDIKASNILLDAD-----YNAKLSDFG--LARDGPMGDLSYVSTRVM--GTY 243 + + +RD+K+ NIL+D ++DFG L + Y S G Sbjct: 183 MNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNR 242 Query: 244 GYAAPEYMSSGHLN------ARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPY 297 APE ++ +SD+++ G + EI + + P ++ + ++ Y Sbjct: 243 ALMAPEIANAKPGTFSWLNYKKSDLWAVGAIAYEI------FNIDNPFYDKTMKLLSKSY 296 Query: 298 LTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSR 339 + + ++ LS R Sbjct: 297 KEEDL-----------PELPDTIPFIIRNLVSNMLSRSTNKR 327 >2CHL-A nrPDB Length = 351 Score = 84.8 bits (208), Expect = 7e-17, Method: Composition-based stats. Identities = 46/227 (20%), Positives = 81/227 (35%), Gaps = 28/227 (12%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYL 125 NFR IG G FG + G T +A+K L + + L E + Sbjct: 31 NFRVGKKIGCGNFGELRLG---------KNLYTNEYVAIK-LEPMKSRAPQLHL-EYRFY 79 Query: 126 GQLSH-PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA 184 QL + ++ + ++ +V E + SLE+ F + +A+ Sbjct: 80 KQLGSGDGIPQVYYFGPCGKYNAMVLELL-GPSLEDLFDLCDRTF---SLKTVLMIAIQL 135 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADYN-----AKLSDFGLARDGPMGDLSYV---- 235 + ++HS +IYRD+K N L+ N + DF LA++ + Sbjct: 136 ISRMEYVHSK--NLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYR 193 Query: 236 -STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDH 281 + GT Y + + R D+ + G + + L G Sbjct: 194 EHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG 240 >2CMW-A nrPDB Length = 310 Score = 84.0 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 54/275 (19%), Positives = 95/275 (34%), Gaps = 36/275 (13%) Query: 68 RPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQ 127 R IG G FG + G T +A+K L + + L E + Q Sbjct: 3 RVGKKIGCGNFGELRLG---------KNLYTNEYVAIK-LEPIKSRAPQLHL-EYRFYKQ 51 Query: 128 LSH--PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAA 185 L L ++ + ++ +V E + SLE+ F + +A+ Sbjct: 52 LGSAGEGLPQVYYFGPCGKYNAMVLELL-GPSLEDLFDLCDRTF---TLKTVLMIAIQLL 107 Query: 186 KGLAFLHSDPVKVIYRDIKASNILLDADYNAK-----LSDFGLARDGPMGDLSYV----- 235 + ++HS +IYRD+K N L+ N K + DFGLA++ + Sbjct: 108 SRMEYVHSK--NLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYRE 165 Query: 236 STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 + GT Y + + R D+ + G + + L G K + L + + Sbjct: 166 HKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQG---LKADTLKERYQ 222 Query: 296 PYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQ 330 +KR + + PEE + Sbjct: 223 KIGDTKRNTPIEAL----CENFPEEMATYLRYVRR 253 >5CLR-A nrPDB Length = 451 Score = 82.8 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 50/295 (16%), Positives = 102/295 (34%), Gaps = 31/295 (10%) Query: 84 GWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLED 143 G G +K + + + E+ E + L +L +L+G + Sbjct: 89 GKSYCEQFKVYALDDGKTYFLKSVKIDA-ESLTEFTNEKDTLSKLG-----RLVGTFFNE 142 Query: 144 EHR--LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYR 201 + + ++ F++ L + ++ + + + + H + +I+R Sbjct: 143 QTQVHYILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHE--LGLIHR 200 Query: 202 DIKASNILLDADYNAKLSDFG-LARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGH---LN 257 D+K NI+LDAD L DFG + D S+ GT Y APE + + Sbjct: 201 DLKPGNIMLDADMQCHLVDFGSSSSDKEPKPASW------GTASYLAPELNAQEDFIAFS 254 Query: 258 ARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYL 317 SD+++ L E+ + + AK + + +L + L + Sbjct: 255 QVSDLFALAYSLDELFN---PFRQVKFAKVD--IGIKNKHLVLLHAEIEACITGLMSNET 309 Query: 318 PEEAVRMASVAVQCLSFEPK---SRPT-MDQVVRALQQLQDNLGKPSQTNPVKDT 368 + + + L P+ SRP ++ L Q + P + + Sbjct: 310 SVRTLYFSRILQ--LQRVPESFKSRPEAFTYLIMLLTQWKSCYEAPEMNKELDEI 362 >4XHL-A nrPDB Length = 394 Score = 81.3 bits (199), Expect = 6e-16, Method: Composition-based stats. Identities = 56/307 (18%), Positives = 100/307 (32%), Gaps = 42/307 (13%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT-EIN 123 R FR IG G FG ++ G T +G +A+ E + L E Sbjct: 7 RKFRIGRKIGSGSFGDIYHG---------TNLISGEEVAI---RLESIRSRHPQLDYESR 54 Query: 124 YLGQLSHPNLVKLIGYC-LEDEHRLLVYEFM--QKGSLENHLFRRGAYFKPLPWFLRVNV 180 LS + I + E E+ +V + + L N+ RR + + + Sbjct: 55 VYRYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRR------FSFKTVIML 108 Query: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLD---ADYNAKLSDFGLARDGPMGDLSYV-- 235 AL + ++H I+RDIK N L+ + DFGL++ + Sbjct: 109 ALQMFCRIQYIH--GRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIP 166 Query: 236 ---STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVD 292 + + GT YA+ + R D+ S G +L+ G + ++ D Sbjct: 167 YRENKSLTGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYD 226 Query: 293 WARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 +++ N + C + + +P + R + L Sbjct: 227 ----------RIMEKKLNVSVETLCSGLPLEFQEYMAYCKNLKFDEKPDYLFLARLFKDL 276 Query: 353 QDNLGKP 359 L Sbjct: 277 SIKLEYH 283 >4NT4-A nrPDB Length = 312 Score = 80.5 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 50/238 (21%), Positives = 80/238 (33%), Gaps = 44/238 (18%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT-EINY 124 NFR IG G FG + G +A+K E + L E + Sbjct: 13 NFRVGKKIGCGNFGELRLG---------KNLYNNEHVAIKM---EPMKSKAPQLHLEYRF 60 Query: 125 LGQL-SH--------PNLVKLIGYCLEDEHRLLVYEFM--QKGSLENHLFRRGAYFKPLP 173 L SH P + L G C + +V E + L N R+ Sbjct: 61 YKLLGSHADNAPDGIPRIYHL-GTC-GGRYNAMVLELLGLSLEDLFNICARK------FS 112 Query: 174 WFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAK-----LSDFGLARDGP 228 + +A + ++HS +IYRD+K N L+ + + DFGLA++ Sbjct: 113 LKTVLMIAKQLLHRIEYVHSR--HLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYI 170 Query: 229 MGDLSYV-----STRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDH 281 D + + GT Y + + R D+ + G + + L G Sbjct: 171 DLDTNRHIPYREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQG 228 >4JRN-A nrPDB Length = 372 Score = 79.4 bits (194), Expect = 3e-15, Method: Composition-based stats. Identities = 54/313 (17%), Positives = 93/313 (29%), Gaps = 79/313 (25%) Query: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR---EWLT 120 TR + +G GGF V++ T T +AVK E + Sbjct: 67 TRTLVRGAPLGSGGFATVYEA---------TDVETNEELAVKVFMSEKEPTDETMLDLQR 117 Query: 121 EINYLGQLS----------------HPNLVKLIGY-CLEDEHRLLVYEFMQKGSLENHLF 163 E + S ++V L G + L ++ + Sbjct: 118 ESSCYRNFSLAKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPN-YFLLMMR 176 Query: 164 RRGAYFKPLPWF--------------LRVNVALDAAKGLAFLHSDPVKVIYRDIKASNIL 209 K + W +R+ ++ A K +A + +++ DIK +N L Sbjct: 177 AEADMSKVISWVFGDASVNKSEFGLVVRMYLSSQAIKLVA--NVQAQGIVHTDIKPANFL 234 Query: 210 LDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPE---YMSSGHLNARSDVYSFG 266 L D L DFG R ++ R +GT GY PE + +D + G Sbjct: 235 LLKDGRLFLGDFGTYR------INNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLG 288 Query: 267 VLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMAS 326 + L I +R + + D P + Sbjct: 289 ITLYCIWCKERPTPADGIWDYLHFAD------------------------CPSTPELVQD 324 Query: 327 VAVQCLSFEPKSR 339 + L+ +P+ R Sbjct: 325 LIRSLLNRDPQKR 337 >1CSN-A nrPDB Length = 298 Score = 78.6 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 58/310 (18%), Positives = 100/310 (32%), Gaps = 40/310 (12%) Query: 66 NFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVK-KLNQEGFQGHREWLTEINY 124 +++ IGEG FG +F+G T +A+K + + R+ Sbjct: 11 HYKVGRRIGEGSFGVIFEG---------TNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKL 61 Query: 125 LGQLSH-PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALD 183 L + PN+ + E H +LV + + SLE+ L G F + A Sbjct: 62 LAGCTGIPNV---YYFGQEGLHNVLVIDLL-GPSLEDLLDLCGRKFSVKTVAMA---AKQ 114 Query: 184 AAKGLAFLHSDPVKVIYRDIKASNILLDADYN-----AKLSDFGLAR-----DGPMGDLS 233 + +H ++YRDIK N L+ + + DFG+ + Sbjct: 115 MLARVQSIHEKS--LVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPY 172 Query: 234 YVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDW 293 + GT Y + + R D+ + G + + L G Sbjct: 173 REKKNLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQG------LKAATN 226 Query: 294 ARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQ 353 + Y K L PEE + A L+F+ P D + ++ Sbjct: 227 KQKYERIGEKKQSTPLREL-CAGFPEEFYKYMHYARN-LAFDAT--PDYDYLQGLFSKVL 282 Query: 354 DNLGKPSQTN 363 + L N Sbjct: 283 ERLNTTEDEN 292 >5DMZ-A nrPDB Length = 365 Score = 78.2 bits (191), Expect = 6e-15, Method: Composition-based stats. Identities = 57/290 (19%), Positives = 102/290 (35%), Gaps = 26/290 (8%) Query: 59 ELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREW 118 E +L ++ ++GEG F V++ + K L + K N F + Sbjct: 59 EFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQ-KPANPWEFYIGTQL 117 Query: 119 LTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFR-RGAYFKPLPWFLR 177 + + + H +K L +LV E G+L N + + K +P L Sbjct: 118 MERLK--PSMQHMF-MKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLV 174 Query: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILL-----------DADYNAKLSDFGLARD 226 ++ A+ + +H +I+ DIK N +L D L D G + D Sbjct: 175 ISFAMRMLYMIEQVHDCE--IIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSID 232 Query: 227 GPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG--KRALDHNRP 284 + + T T G+ E +S+ N + D + + +L G + + Sbjct: 233 MKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGE 292 Query: 285 AKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSF 334 K E L P+L + ++ N D +LP + Q L Sbjct: 293 CKPEGLFR-RLPHLDMWNEFFHVMLNIPDCHHLPS-----LDLLRQKLKK 336 >5UU1-A nrPDB Length = 324 Score = 72.0 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 60/340 (17%), Positives = 113/340 (33%), Gaps = 62/340 (18%) Query: 38 AAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPG 97 + EG++L + IG GGFG ++ + + Sbjct: 1 SMPFPEGKVLDDMEGNQWVL------------GKKIGSGGFGLIYLAFPTNKP----EKD 44 Query: 98 TGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVK---------------LIGYCLE 142 V+ V +Q + +E+ + +++ + +K G L Sbjct: 45 ARHVVKV------EYQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLT 98 Query: 143 D----EHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKV 198 + +R +V E + L+ + G + K + + + L ++H + Sbjct: 99 EFKGRSYRFMVMERL-GIDLQKISGQNGTFKK----STVLQLGIRMLDVLEYIHENE--Y 151 Query: 199 IYRDIKASNILL--DADYNAKLSDFGLA-RDGPMGDLSYVSTRVM----GTYGYAAPEYM 251 ++ DIKA+N+LL L+D+GL+ R P G+ GT + + + Sbjct: 152 VHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAH 211 Query: 252 SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNR 311 L+ RSDV G +L L GK E+NL D + + + Sbjct: 212 KGVALSRRSDVEILGYCMLRWLCGKLPW-------EQNLKDPVAVQTAKTNLLDELPQSV 264 Query: 312 LDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQ 351 L +A V S +P + + L Sbjct: 265 LKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNP 304 >4OAU-C nrPDB Length = 699 Score = 65.5 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 29/125 (23%), Positives = 47/125 (37%), Gaps = 8/125 (6%) Query: 99 GLVIAVKKLNQEGFQGHREWLTEINYLGQLS-HPNLVKLIGYCLEDEHRLLVYEFMQKGS 157 +AVK +G E++ L + +LV G H + + + Sbjct: 366 KQEVAVKTF----CEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCE-QT 420 Query: 158 LENHL-FRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA 216 LE L RG + NV K + LH ++D++ NIL+D+ A Sbjct: 421 LEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELH-LSCGYTHQDLQPQNILIDSKKAA 479 Query: 217 KLSDF 221 L+DF Sbjct: 480 HLADF 484 >2RSV-A nrPDB Length = 403 Score = 64.3 bits (155), Expect = 8e-11, Method: Composition-based stats. Identities = 62/351 (17%), Positives = 125/351 (35%), Gaps = 47/351 (13%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTE 121 +A + ++ IG+GGFGC++ ++ S G+ VK + TE Sbjct: 39 MAKKEWKVGLPIGQGGFGCIYLADMNSSESV----GSDAPCVVKV----EPSDNGPLFTE 90 Query: 122 INYL---------------GQLSHPNLVKLIGYCLEDEH----RLLVYEFMQKGSLENHL 162 + + +L + + K G L D++ R ++ + + GS + Sbjct: 91 LKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMD--RFGSDLQKI 148 Query: 163 FRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLD--ADYNAKLSD 220 + A K + ++L L ++H ++ DIKASN+LL+ L D Sbjct: 149 YE--ANAKRFSRKTVLQLSLRILDILEYIHEHE--YVHGDIKASNLLLNYKNPDQVYLVD 204 Query: 221 FGLA-RDGPMGDLSYVSTRVM----GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 +GLA R P G GT + + + + + R D+ G +++ L+G Sbjct: 205 YGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTG 264 Query: 276 KRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFE 335 + N + + D Y + + ++D + P E + + Sbjct: 265 HLPWEDNL-KDPKYVRDSKIRY---RENIASLMDKCFPEKNKPGEIAKYMETVKL---LD 317 Query: 336 PKSRPTMDQVVRALQQLQDNLGKPSQTNPVKDTKKLGFKTGTTKSSEKRFT 386 +P + + L Q +G + G T + +++ Sbjct: 318 YTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKKE 368 >2LAV-A nrPDB Length = 361 Score = 64.3 bits (155), Expect = 1e-10, Method: Composition-based stats. Identities = 62/351 (17%), Positives = 125/351 (35%), Gaps = 47/351 (13%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTE 121 +A + ++ IG+GGFGC++ ++ S G+ VK + TE Sbjct: 32 MAKKEWKVGLPIGQGGFGCIYLADMNSSESV----GSDAPCVVKV----EPSDNGPLFTE 83 Query: 122 INYL---------------GQLSHPNLVKLIGYCLEDEH----RLLVYEFMQKGSLENHL 162 + + +L + + K G L D++ R ++ + + GS + Sbjct: 84 LKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMD--RFGSDLQKI 141 Query: 163 FRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLD--ADYNAKLSD 220 + A K + ++L L ++H ++ DIKASN+LL+ L D Sbjct: 142 YE--ANAKRFSRKTVLQLSLRILDILEYIHEHE--YVHGDIKASNLLLNYKNPDQVYLVD 197 Query: 221 FGLA-RDGPMGDLSYVSTRVM----GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSG 275 +GLA R P G GT + + + + + R D+ G +++ L+G Sbjct: 198 YGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTG 257 Query: 276 KRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFE 335 + N + + D Y + + ++D + P E + + Sbjct: 258 HLPWEDNL-KDPKYVRDSKIRY---RENIASLMDKCFPEKNKPGEIAKYMETVKL---LD 310 Query: 336 PKSRPTMDQVVRALQQLQDNLGKPSQTNPVKDTKKLGFKTGTTKSSEKRFT 386 +P + + L Q +G + G T + +++ Sbjct: 311 YTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKKE 361 >4O1O-A nrPDB Length = 717 Score = 64.0 bits (154), Expect = 1e-10, Method: Composition-based stats. Identities = 24/124 (19%), Positives = 48/124 (38%), Gaps = 9/124 (7%) Query: 100 LVIAVKKLNQEGFQGHREWLTEINYLGQLS-HPNLVKLIGYCLEDEHRLLVYEFMQKGSL 158 +AVK+ ++ +G + E++ L + N+V G + + + +L Sbjct: 370 QEVAVKRFSEGSTRGQQ----EVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEY-TL 424 Query: 159 ENHLFRRGAYFKPLPWFLRVN-VALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAK 217 + HL P + K + LH ++D++ NIL+D+ Sbjct: 425 QEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRS--GYSHQDLQPQNILIDSKNGTF 482 Query: 218 LSDF 221 L+DF Sbjct: 483 LADF 486 >6G4J-A nrPDB Length = 315 Score = 60.9 bits (146), Expect = 9e-10, Method: Composition-based stats. Identities = 30/217 (13%), Positives = 69/217 (31%), Gaps = 42/217 (19%) Query: 65 RNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINY 124 + +G+G G V+ + +A+K +E+N Sbjct: 26 NTYTLRKQLGKGANGIVYLAETSDGH-----------VALKV-----SDDSLSITSEVNV 69 Query: 125 LGQLSHPNLVKLIGYCLEDEHRLL----------VYEFMQKGSLENHLFRRGAYFKPLPW 174 L S V + + + + E+++ L ++ +GA + P+ Sbjct: 70 LKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPV-- 127 Query: 175 FLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDA-DYNAKLSDFGLARDGPMGDLS 233 + + L+ LH I+ D+K N+++ + D G Sbjct: 128 -----LMIQLLSSLSVLHQQ--GWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKE 180 Query: 234 YVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLL 270 Y G +GY + D+++ ++++ Sbjct: 181 YTEFYDRGYWGY------GTRKAEPSYDLFAVAMIMI 211 >4IX6-A nrPDB Length = 350 Score = 60.5 bits (145), Expect = 1e-09, Method: Composition-based stats. Identities = 42/252 (16%), Positives = 71/252 (28%), Gaps = 67/252 (26%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPN 132 +G G FG VF+G K V+A ++L + + H N Sbjct: 28 LGSGNFGTVFRGVFKGDQDVVLKNAKADVMAAEELLECEMDVNYHV-----------HAN 76 Query: 133 ----LVKLIGYCL----EDEHRL--LVYE---FM---QKGSLENHLFRRGAY-------- 168 + +G + + E M + + L RRG Sbjct: 77 AKGTCARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMAC 136 Query: 169 FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDAD--YNAKLSDFGLAR- 225 + + LA LH V++RD+K +N++ KL D G A Sbjct: 137 ADATELGVTKKAMRELLGSLARLHE--CGVVHRDVKPANLIAAEKDGGVLKLIDLGAAAL 194 Query: 226 -DGPMGDLSYVSTRVMGTYGY--------AAP--------------EYMSSGHLNARSDV 262 L+Y Y P E ++ Sbjct: 195 CLPLPETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDS---- 250 Query: 263 YSFGVLLLEILS 274 +S G ++L++ Sbjct: 251 WSAGCVMLQLAV 262 >6M7Z-A nrPDB Length = 319 Score = 58.2 bits (139), Expect = 6e-09, Method: Composition-based stats. Identities = 36/235 (15%), Positives = 81/235 (34%), Gaps = 55/235 (23%) Query: 141 LEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIY 200 ++ + KG + + L ++ +A + L LH+ + +++ Sbjct: 116 YRGAFLTYIFHPLSKGLVGDMLETGRSHPD------VQVLAANMVAALKSLHN--LGLLH 167 Query: 201 RDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEY---------M 251 R I+ ++ + D L GL P+G + + G APE + Sbjct: 168 RSIELNSFSVLPDGTVVLG--GLDTAAPIGTETRLWVGFFGQE--TAPEIDRNFLADLAL 223 Query: 252 SSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNR 311 + G +SDVYS GV R + L ++R Sbjct: 224 TQGRHTVKSDVYSLGV-------------------------AFRNLVQLLGNGNLGPEDR 258 Query: 312 LDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRA-------LQQLQDNLGKP 359 + + ++ + + EP +RPT++++++ + +++ +P Sbjct: 259 --GAVRQDHLELLDKLSQKMIEEEPGNRPTIEEIMKDPLFEGLNFEDIEEGKARP 311 >6EWX-A nrPDB Length = 484 Score = 56.6 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 40/255 (15%), Positives = 74/255 (29%), Gaps = 66/255 (25%) Query: 142 EDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA---LDAAKGLAFLHSDPVKV 198 E + +++ + + + + A + P V L GL L + Sbjct: 174 EQDCVVVITREVPHQTASDFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHL--KEHGI 231 Query: 199 IYRDIKASNILLDADY-----------------------------------------NAK 217 I+RD+ N+LL Sbjct: 232 IHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLI 291 Query: 218 LSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKR 277 +S+F A+ P G + + APE +S+ + D + G+L+ E+L Sbjct: 292 ISNFLKAKQKPGGTTNLQQKKSQAR---LAPEIVSASQY-RKFDEFQTGILIYELLHQPN 347 Query: 278 ALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPK 337 + +E + P L L + + +A L +P Sbjct: 348 PFEVRAQLRERDYRREDLPPL----------------PTLSLYSPGLQQLAHLLLEADPI 391 Query: 338 SRPTMDQVVRALQQL 352 R + + R LQ L Sbjct: 392 KRIRIGEAKRVLQCL 406 >6BHC-A nrPDB Length = 438 Score = 56.3 bits (134), Expect = 2e-08, Method: Composition-based stats. Identities = 47/292 (16%), Positives = 89/292 (30%), Gaps = 65/292 (22%) Query: 102 IAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCL----------------EDEH 145 AVK + + + + + H N+ + G+ L + H Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPSKKQRSH 145 Query: 146 RLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDA---AKGLAFLHSDPVKVIYRD 202 +++ + ++ + + A P V L GL L P V + D Sbjct: 146 VVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHL--KPYHVTHCD 203 Query: 203 IKASNILL-------------------DADYNAKL--SDFGLAR-DGPMGDLSYVSTRVM 240 ++ N+LL + Y +L S+F A+ + D + + Sbjct: 204 LRLENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSR 263 Query: 241 GTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTS 300 APE +++ + D + G+L+ E+L D N KE P Sbjct: 264 -----LAPEIITATQY-KKCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADLP---- 313 Query: 301 KRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQL 352 + + + +A L+ P R + LQ L Sbjct: 314 ------------RIPFRSPYSRGLQQLASCLLNPNPSERILISDAKGILQCL 353 >4CI6-B nrPDB Length = 643 Score = 55.1 bits (131), Expect = 5e-08, Method: Composition-based stats. Identities = 35/216 (16%), Positives = 68/216 (31%), Gaps = 32/216 (14%) Query: 88 ESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQL-----SHPNLVKLIG--YC 140 ES ++ + + K E E+ + HPNL + G Sbjct: 57 ESHISIIETKDKQRLVAKI---ERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVV 113 Query: 141 LEDEHRL--LVYEFMQKGSLENHLF------RRGAYFKPLPWFLRVNVALDAAKGLAFLH 192 L+ + + + L ++G W +A L Sbjct: 114 PYGNRYYYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHL- 172 Query: 193 SDPVKVIYRDIKASNILLD-ADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEY- 250 +++ DIK N++ D A + D GL + T + APE Sbjct: 173 -AKAGIVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGF-------TESFKAPELG 224 Query: 251 MSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAK 286 + + + +SDV+ +++ +L G + + K Sbjct: 225 VGNLGASEKSDVF---LVVSTLLHGIEGFEKDPEIK 257 >2JII-A nrPDB Length = 352 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 41/224 (18%), Positives = 79/224 (35%), Gaps = 19/224 (8%) Query: 140 CLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVI 199 +D++R LV + SL++ L + L + VA L FLH + + Sbjct: 127 VHQDKYRFLVLPSL-GRSLQSALDVSPKH--VLSERSVLQVACRLLDALEFLHENE--YV 181 Query: 200 YRDIKASNILLD--ADYNAKLSDFGLA-RDGPMGDLSYVSTRVM----GTYGYAAPEYMS 252 + ++ A NI +D L+ +G A R P G G + + + Sbjct: 182 HGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHK 241 Query: 253 SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRL 312 + RSD+ S G +L+ L G + P E+ + + V Sbjct: 242 GCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIR 301 Query: 313 DTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNL 356 ++ L + + ++ + +P + L+ L +L Sbjct: 302 PSETLQKYLKVVMALTY-------EEKPPYAMLRNNLEALLQDL 338 >4AZW-A nrPDB Length = 471 Score = 50.1 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 26/126 (20%), Positives = 45/126 (35%), Gaps = 16/126 (12%) Query: 109 QEGFQGHREWLTEINYLGQ----LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFR 164 +E + E EI +L Q P ++ + + LV E + L + L Sbjct: 279 EESQRNKHELHNEIKFLTQPPAGFDAP---AVLAHGENAQSGWLVMEKLPGRLLSDMLAA 335 Query: 165 RGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLA 224 R + + LA L + D++ N+++DA +A+L DFG Sbjct: 336 GE-------EIDREKILGSLLRSLAALEKK--GFWHDDVRPWNVMVDARQHARLIDFGSI 386 Query: 225 RDGPMG 230 P Sbjct: 387 VTTPQD 392 >4AZV-A nrPDB Length = 569 Score = 48.5 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 26/126 (20%), Positives = 46/126 (36%), Gaps = 16/126 (12%) Query: 109 QEGFQGHREWLTEINYLGQ----LSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFR 164 +E + E EI +L Q P ++ + + LV E + L + L Sbjct: 279 EESQRNKYELHNEIKFLTQPPAGFDAP---AVLAHGENAQSGWLVMEKLPGRLLSDMLAA 335 Query: 165 RGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLA 224 R + + LA L + + D++ N+++DA +A+L DFG Sbjct: 336 GE-------EIDREKILGSLLRSLAAL--EKQGFWHDDVRPWNVMVDARQHARLIDFGSI 386 Query: 225 RDGPMG 230 P Sbjct: 387 VTTPQD 392 >5VE6-A nrPDB Length = 492 Score = 45.8 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 14/72 (19%), Positives = 27/72 (37%), Gaps = 5/72 (6%) Query: 142 EDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA---LDAAKGLAFLHSDPVKV 198 E + +++ + + + + A + P V L GL L + Sbjct: 172 EQDCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHL--KEHGI 229 Query: 199 IYRDIKASNILL 210 I+RD+ N+LL Sbjct: 230 IHRDLCLENLLL 241 Score = 38.5 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 26/135 (19%), Positives = 47/135 (34%), Gaps = 20/135 (14%) Query: 218 LSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKR 277 +S+F A+ P G + + APE +S+ + D + G+L+ E+L Sbjct: 300 ISNFLKAKQKPGGTPNLQQKKSQAR---LAPEIVSASQY-RKFDEFQTGILIYELLHQPN 355 Query: 278 ALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPK 337 + +E + P L L + + +A L +P Sbjct: 356 PFEVRAQLRERDYRQEDLPPL----------------PALSLYSPGLQQLAHLLLEADPI 399 Query: 338 SRPTMDQVVRALQQL 352 R + + R LQ L Sbjct: 400 KRIRIGEAKRVLQCL 414 >3ENH-A nrPDB Length = 540 Score = 45.8 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 30/193 (15%), Positives = 69/193 (35%), Gaps = 46/193 (23%) Query: 56 TFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH 115 E+K R P+ +IG+G + + + + +K+ ++G++ Sbjct: 328 WIKEIKGKKRKI-PEHLIGKGA-----EADIKRDSYLDFD------VIIKERVKKGYRDE 375 Query: 116 R--------EWLTEINYLGQLSH-----PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHL 162 R E YL + P + L+++ ++ ++ ++ + Sbjct: 376 RLDENIRKSRTAREARYLALVKDFGIPAPYI---FDVDLDNKR--IMMSYINGKLAKDVI 430 Query: 163 FRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFG 222 +++A + + LH + VI+ D+ SN + D D + DFG Sbjct: 431 EDN------------LDIAYKIGEIVGKLHKND--VIHNDLTTSNFIFDKD--LYIIDFG 474 Query: 223 LARDGPMGDLSYV 235 L + + + V Sbjct: 475 LGKISNLDEDKAV 487 >6G38-A nrPDB Length = 357 Score = 43.9 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 32/194 (16%), Positives = 56/194 (28%), Gaps = 64/194 (32%) Query: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL--------NQEGFQ 113 L T + IGEG FG VF+ D + +A+K + N + Sbjct: 38 LPTEKLQRCEKIGEGVFGEVFQTIADHTP-----------VAIKIIAIEGPDLVNGSHQK 86 Query: 114 GHREWLTEINYLGQ-----------------LSHPNLVK------LIGY----------- 139 E L EI + L+ + V+ L+ Sbjct: 87 TFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSA 146 Query: 140 -----CLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSD 194 +D+ +V EF G + K ++ LA + Sbjct: 147 NDRPDFFKDDQLFIVLEFEFGG-----IDLEQMRTKLSSLATAKSILHQLTASLA-VAEA 200 Query: 195 PVKVIYRDIKASNI 208 ++ +RD+ N+ Sbjct: 201 SLRFEHRDLHWGNV 214 >4CYJ-A nrPDB Length = 438 Score = 43.5 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 28/155 (18%), Positives = 56/155 (36%), Gaps = 24/155 (15%) Query: 78 FGC---VFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLV 134 FG V+K G A+++L + L + ++ + ++V Sbjct: 65 FGYPSWVYKAQNSR---------NGRHYALRRLEGYRLTNEKAILNVMKDWKKIKNASIV 115 Query: 135 KLIGYCLE----DEHRLLVYEFMQ-KGSLENHLFR--RGAYFKP---LPWFLRVNVALDA 184 + D + Y+F +L+ H F+ G ++P +P Sbjct: 116 TIHEVFTTREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQI 175 Query: 185 AKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLS 219 A L +HS+ ++ R ++ S I+L +LS Sbjct: 176 ANALKTIHSN--RLAARCLEPSKIILTDINRIRLS 208 >3BYV-A nrPDB Length = 377 Score = 42.8 bits (99), Expect = 3e-04, Method: Composition-based stats. Identities = 40/256 (15%), Positives = 91/256 (35%), Gaps = 47/256 (18%) Query: 103 AVKKLNQEGFQGHREWLTEINYLGQLS-HPNLV------------KLIGYCLEDEHRLLV 149 A+K++ +E + L I Q H + K+I L++ ++ Sbjct: 116 AIKQMKEEVLR--LRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERDMWVL 173 Query: 150 ---YEFMQKGS-LENH---LFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRD 202 + + + S L+ L + K L R+ + L + LA LH +++ Sbjct: 174 SRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHH--YGLVHTY 231 Query: 203 IKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGH------- 255 ++ +I+LD L+ F + + D + V + V + G+ PE + Sbjct: 232 LRPVDIVLDQRGGVFLTGF----EHLVRDGARVVSSV--SRGFEPPELEARRATISYHRD 285 Query: 256 ----LNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNR 311 + D ++ G+++ I + P ++ + + S + + V Sbjct: 286 RRTLMTFSFDAWALGLVIYWI------WCADLPITKDAALGGSEWIFRSCKNIPQPVRAL 339 Query: 312 LDTQYLPEEAVRMASV 327 L+ + R+ + Sbjct: 340 LEGFLRYPKEDRLLPL 355 >4BWP-A nrPDB Length = 448 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 26/173 (15%), Positives = 56/173 (32%), Gaps = 38/173 (21%) Query: 83 KGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLE 142 K +T T TG +++++ Q + +T + +L H N+V+L Sbjct: 59 KLTFPATTYRATHNTTGYKYCLRRIHGFRLQSTK-CMTLVEMWKKLQHTNVVQLREVFTT 117 Query: 143 ----DEHRLLVYEFMQK--GSLENHLF-------------------------RRGAYFKP 171 D +LVY++ L + +R + Sbjct: 118 KAFGDNSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPL 177 Query: 172 LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY----NAKLSD 220 LP ++ + GL +H + + + + I++ + +SD Sbjct: 178 LPEATIWSIIMQLTAGLKAIHH--AGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >3DZO-A nrPDB Length = 413 Score = 42.0 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 44/306 (14%), Positives = 99/306 (32%), Gaps = 48/306 (15%) Query: 103 AVKKLNQEGFQGHREWLTEINYLGQLS-HPNLV------------KLIGYCLEDEHRLLV 149 A+K++ +E + L I Q H + K+I L++ ++ Sbjct: 121 AIKQMKEEVLR--LRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKKMIRVRLDERDMWVL 178 Query: 150 ---YEFMQKGS-LENH---LFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRD 202 + + + S L+ L + K L R+ + L + LA LH +++ Sbjct: 179 SRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASLHH--YGLVHTY 236 Query: 203 IKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGH-----LN 257 ++ +I+LD L+ F +S + A + G + Sbjct: 237 LRPVDIVLDQRGGVFLTGFEHLVRDGASAVSPIGRGFA-PPETTAERMLPFGQHHPTLMT 295 Query: 258 ARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYL 317 D ++ G+ + I + P ++ + + S + + V L+ Sbjct: 296 FAFDTWTLGLAIYWI------WCADLPNTDDAALGGSEWIFRSCKNIPQPVRALLEGFLR 349 Query: 318 PEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVKDTKKLGFKTGT 377 + R+ + + P +Q+ L + P + T++ G Sbjct: 350 YPKEDRLLPL-------QAMETPEYEQLRTEL-----SAALPLYQTDGEPTREGGAPPSG 397 Query: 378 TKSSEK 383 T ++ Sbjct: 398 TSQPDE 403 >4WWA-A nrPDB Length = 261 Score = 41.2 bits (95), Expect = 8e-04, Method: Composition-based stats. Identities = 36/175 (20%), Positives = 58/175 (33%), Gaps = 35/175 (20%) Query: 73 IGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR--------EWLTEINY 124 I +G VF P + +K + ++ + L E Sbjct: 22 ISQGAEAIVF--TTTTHPYLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRL 79 Query: 125 LGQLSHPNLV------KLIGYCLEDEHRLLVY--EFMQKG----SLENHLFRRGAY-FKP 171 L +L L+ +LI + L + E + G +L+N L+ + Sbjct: 80 LAKL---YLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSD 136 Query: 172 LPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADY---NAKLSDFGL 223 L V GL LH + + D+ +SNI+L D L DFGL Sbjct: 137 LVATTLRKVGRQI--GL--LHWND--YCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >2W1Z-A nrPDB Length = 368 Score = 37.8 bits (86), Expect = 0.009, Method: Composition-based stats. Identities = 33/194 (17%), Positives = 65/194 (33%), Gaps = 32/194 (16%) Query: 103 AVKKLNQEGFQGHREWLTEINYLGQ-------------LSHPNLVKLIGYCLEDEHRLLV 149 A+K+L+++ + L I Q + P K+I L++ ++ Sbjct: 101 AIKQLSEQVLR--LRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERDMWVL 158 Query: 150 ---YEFMQKGS----LENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRD 202 + + + S L + L + K L R+ + L + A L +++ D Sbjct: 159 SRFFLYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASL--QHYGLVHAD 216 Query: 203 IKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGH------L 256 + NILLD L+ F +S + A E M + Sbjct: 217 FQVRNILLDQRGGVFLTGFEHLVRDGASAVSPIGRGFA-PPETTA-ERMLPYRQHHPTLM 274 Query: 257 NARSDVYSFGVLLL 270 D ++ G+ + Sbjct: 275 TFPFDTWTLGLAIY 288 >5YK0-A nrPDB Length = 452 Score = 37.4 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 15/92 (16%), Positives = 34/92 (36%), Gaps = 15/92 (16%) Query: 131 PNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAF 190 P++V ++++ E+++ + + + L L + DA + L Sbjct: 235 PHVVA-------SAPKVVIQEWIEGVPMAEIIRHGTTEQRDLIGTLLAELTFDAPRRL-- 285 Query: 191 LHSDPVKVIYRDIKASNILLDADYNAKLSDFG 222 +++ D N +L D + DFG Sbjct: 286 ------GLMHGDAHPGNFMLLPDGRMGIIDFG 311 >1TQM-A nrPDB Length = 282 Score = 37.4 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 27/165 (16%), Positives = 54/165 (32%), Gaps = 34/165 (20%) Query: 69 PDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGH--------REWLT 120 ++GEG VF + ++ K + KK+ ++ G R Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 121 EINYLGQLSHPNLVKLIGYCLEDEHRL----LVYEFMQKGSLENHLFRRGAYFKPLPWFL 176 E L +L G + + ++ E + L + R + L Sbjct: 154 EFRALQKLQ--------GLAVPKVYAWEGNAVLMELIDAKEL--YRVRVENPDEVLDM-- 201 Query: 177 RVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDF 221 + + AK F H +++ D+ N+L+ + + DF Sbjct: 202 ---ILEEVAK---FYH---RGIVHGDLSQYNVLVSEEG-IWIIDF 236 >3Q60-A nrPDB Length = 371 Score = 36.2 bits (82), Expect = 0.027, Method: Composition-based stats. Identities = 26/164 (15%), Positives = 54/164 (32%), Gaps = 20/164 (12%) Query: 194 DPVKVIYRDIKASNILLDADYNAKLSDFG-LARDGPMGDLSYVSTRVMGTYGYAAP-EYM 251 +++ N+ + D L D L + G G S V AP E++ Sbjct: 211 QSKGLVHGHFTPDNLFIMPDGRLMLGDVSALWKVGTRGPASSVPVTY-------APREFL 263 Query: 252 S--SGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVD 309 + + + + G+ + + P + + W RP L L Sbjct: 264 NASTATFTHALNAWQLGLSIYRVWCLFLPFGLVTPGIKGS---WKRPSLRVPGTDSLAFG 320 Query: 310 NRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQ 353 LP+ + ++ + L+F+ + R + + + LQ Sbjct: 321 ---SCTPLPDF---VKTLIGRFLNFDRRRRLLPLEAMETPEFLQ 358 >4CZY-B nrPDB Length = 429 Score = 35.4 bits (80), Expect = 0.044, Method: Composition-based stats. Identities = 22/140 (15%), Positives = 47/140 (33%), Gaps = 14/140 (10%) Query: 91 LTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLE----DEHR 146 G A++++ + L ++ + N+V + D Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTTEFFGDSSL 120 Query: 147 LLVYEFMQ-KGSLENHL------FRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVI 199 + VY+F +L +H R +P L + A L +H+ K+ Sbjct: 121 IFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHN--AKLA 178 Query: 200 YRDIKASNILLDADYNAKLS 219 R ++ S I + + +L+ Sbjct: 179 ARCLELSKI-IWENNRIRLA 197 >6DFL-A nrPDB Length = 259 Score = 34.7 bits (78), Expect = 0.065, Method: Composition-based stats. Identities = 32/185 (17%), Positives = 60/185 (32%), Gaps = 25/185 (13%) Query: 79 GCVFKGWLDESTLTPTKPGTGLVIAV----------KKLNQEGFQGHREWLTEINYLGQL 128 G V++ TL G G + + K L E + +L Sbjct: 27 GKVYRELEGRRTLRTEVDGRGYFVKIHRGIGWGEIAKNLLTAKLPVL-GARQEWQAIRRL 85 Query: 129 SHPNLVKLIGYCLED-------EHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVA 181 + + + +H +V E + +++ +F + +P P L+ + Sbjct: 86 HEAGVATMTAVAYGERGSDPARQHSFIVTEELAP-TVDLEVFSQDWRERPPPPRLKRALV 144 Query: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMG 241 A+ + +H V +RD + LL D DF L+ + DL TR Sbjct: 145 EAVARMVGDMH--RAGVNHRDCYICHFLLHTDKPVSADDFRLS----VIDLHRAQTRDAT 198 Query: 242 TYGYA 246 + Sbjct: 199 PKRWR 203 >6GL3-A nrPDB Length = 386 Score = 33.9 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 16/93 (17%), Positives = 34/93 (36%), Gaps = 9/93 (9%) Query: 157 SLENHLFRRGAYFKPLPWFLRVNVALDAAKG---LAFLHSDPVKVIYRDIKASNILLDAD 213 SL ++ + + + + + G + +L + +D NILLDA+ Sbjct: 217 SLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYL------LQVKDRHNGNILLDAE 270 Query: 214 YNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYA 246 + DFG +L + ++ T + Sbjct: 271 GHIIHIDFGFILSSSPRNLGFETSAFKLTTEFV 303 >5C4G-E nrPDB Length = 529 Score = 33.5 bits (75), Expect = 0.15, Method: Composition-based stats. Identities = 16/93 (17%), Positives = 34/93 (36%), Gaps = 9/93 (9%) Query: 157 SLENHLFRRGAYFKPLPWFLRVNVALDAAKG---LAFLHSDPVKVIYRDIKASNILLDAD 213 SL ++ + + + + + G + +L + +D NILLDA+ Sbjct: 359 SLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYL------LQVKDRHNGNILLDAE 412 Query: 214 YNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYA 246 + DFG +L + ++ T + Sbjct: 413 GHIIHIDFGFILSSSPRNLGFETSAFKLTTEFV 445 >4D0L-A nrPDB Length = 566 Score = 33.5 bits (75), Expect = 0.15, Method: Composition-based stats. Identities = 16/93 (17%), Positives = 34/93 (36%), Gaps = 9/93 (9%) Query: 157 SLENHLFRRGAYFKPLPWFLRVNVALDAAKG---LAFLHSDPVKVIYRDIKASNILLDAD 213 SL ++ + + + + + G + +L + +D NILLDA+ Sbjct: 396 SLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYL------LQVKDRHNGNILLDAE 449 Query: 214 YNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYA 246 + DFG +L + ++ T + Sbjct: 450 GHIIHIDFGFILSSSPRNLGFETSAFKLTTEFV 482 >6GML-W nrPDB Length = 584 Score = 33.1 bits (74), Expect = 0.21, Method: Composition-based stats. Identities = 21/84 (25%), Positives = 37/84 (44%), Gaps = 5/84 (5%) Query: 106 KLNQEGFQGHREWLTEINYLGQLSHPNLVKLI-GYCLEDEHRLLVYEFMQ-KGSLEN--- 160 +L + H L EI+ QL HP +++L+ + +L V E ++ K +L + Sbjct: 436 QLQTDHTPVHLALLDEISTCHQLLHPQVLQLLVKLFETEHSQLDVMEQLELKKTLLDRMV 495 Query: 161 HLFRRGAYFKPLPWFLRVNVALDA 184 HL RG + + + LD Sbjct: 496 HLLSRGYVLPVVSYIRKCLEKLDT 519 >5L3X-B nrPDB Length = 405 Score = 32.8 bits (73), Expect = 0.25, Method: Composition-based stats. Identities = 24/84 (28%), Positives = 38/84 (45%), Gaps = 5/84 (5%) Query: 106 KLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLL-VYEFMQ-KGSLEN--- 160 +L + H L EI+ QL HP +++L+ E EH L V E ++ K +L + Sbjct: 257 QLQTDHTPVHLALLDEISTCHQLLHPQVLQLLVKLFETEHSALDVMEQLELKKTLLDRMV 316 Query: 161 HLFRRGAYFKPLPWFLRVNVALDA 184 HL RG + + + LD Sbjct: 317 HLLSRGYVLPVVSYIRKCLEKLDT 340 >6G18-v nrPDB Length = 552 Score = 31.2 bits (69), Expect = 0.91, Method: Composition-based stats. Identities = 15/75 (20%), Positives = 25/75 (33%), Gaps = 14/75 (18%) Query: 148 LVYEFMQKGSL-ENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKAS 206 +V E + L + H A L V +A +I+ D Sbjct: 186 VVMELINGYPLCQIHHVEDPASVYDEAMELIVKLA-------------NHGLIHGDFNEF 232 Query: 207 NILLDADYNAKLSDF 221 N++LD + + DF Sbjct: 233 NLILDESDHITMIDF 247 >4BVU-A nrPDB Length = 211 Score = 30.8 bits (68), Expect = 0.98, Method: Composition-based stats. Identities = 24/149 (16%), Positives = 46/149 (30%), Gaps = 32/149 (21%) Query: 69 PDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQL 128 +IG+G +F+ D S L G EI + Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALYKKYDLIGNQY-----------------NEILEMAWQ 86 Query: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGL 188 L + +V ++ G + +L PL ++ D + L Sbjct: 87 ESE----LFNAFY-GDEASVVIQY--GGDV--YLRMLRVPGTPLSDIDTADIP-DNIESL 136 Query: 189 AFLHS----DPVKVIYRDIKASNILLDAD 213 +L + + +I+ D+ N+L D + Sbjct: 137 -YLQLICKLNELSIIHYDLNTGNMLYDKE 164 >6FDN-A nrPDB Length = 320 Score = 30.8 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 15/75 (20%), Positives = 25/75 (33%), Gaps = 14/75 (18%) Query: 148 LVYEFMQKGSL-ENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKAS 206 +V E + L + H A L V +A +I+ D Sbjct: 186 VVMELINGYPLCQIHHVEDPASVYDEAMELIVKLA-------------NHGLIHGDFNEF 232 Query: 207 NILLDADYNAKLSDF 221 N++LD + + DF Sbjct: 233 NLILDESDHITMIDF 247 >6D6Q-K nrPDB Length = 960 Score = 30.8 bits (68), Expect = 1.2, Method: Composition-based stats. Identities = 15/81 (18%), Positives = 32/81 (39%), Gaps = 16/81 (19%) Query: 201 RDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAA-------PEYMSS 253 R+++ N+ + ++D ++ G+ + GT Y PE +SS Sbjct: 495 RELENGNLEVG----VHIAD--VSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSS 548 Query: 254 GHLNARSDV--YSFGVLLLEI 272 + + DV +F + E+ Sbjct: 549 NLCSLKCDVDRLAFSCI-WEM 568 >5TVA-A nrPDB Length = 240 Score = 30.4 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 37/166 (22%), Positives = 59/166 (35%), Gaps = 14/166 (8%) Query: 21 DLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGC 80 DL+ + + ++K+ V+ A++ + T VK + N + + V F Sbjct: 2 DLFSVRMRAQKNGKHVSGAERIVKKEELETAVKELLNRPKEFDFMNVKVEKVK---DF-E 57 Query: 81 VFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEINYLGQLSHPNLVKLIGYC 140 V K L ST + P AVKKL QEG + + L + ++P + G Sbjct: 58 VVKFNLKISTYSFKSPEEAREFAVKKLTQEGIK-EEVAKKAVEILSKGANPKGGNMRGAV 116 Query: 141 LEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAK 186 L D ++ G RG W R V K Sbjct: 117 LMD---------IETGERLEEDKERGVRTIHFDWKDRKKVTEKLLK 153 >3S42-B nrPDB Length = 276 Score = 30.1 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 16/68 (23%), Positives = 31/68 (45%), Gaps = 3/68 (4%) Query: 325 ASVAVQCLSFEPKSRPTMDQVVRALQQLQDNLGKPSQTNPVKDTKKLGFKTGTTKSSE-- 382 +VAV + + P +++V+ L+++Q+ LG V K T T + E Sbjct: 158 HNVAVIMSNHDFHKTPAAEEIVQRLRKMQE-LGADIPKIAVMPQTKADVLTLLTATVEMQ 216 Query: 383 KRFTQKPF 390 +R+ +P Sbjct: 217 ERYADRPI 224 >6DK4-A nrPDB Length = 142 Score = 30.1 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 7/32 (21%), Positives = 14/32 (43%) Query: 106 KLNQEGFQGHREWLTEINYLGQLSHPNLVKLI 137 L + + + L + L + HPN+ +L Sbjct: 6 MLKKHELKATPQRLCVLKILKRHEHPNIDELY 37 >2X8T-A nrPDB Length = 471 Score = 29.7 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 8/28 (28%), Positives = 12/28 (42%) Query: 129 SHPNLVKLIGYCLEDEHRLLVYEFMQKG 156 HPN+V + +D +VY G Sbjct: 165 KHPNVVDPHTFFDKDGKLWMVYGSYSGG 192 >1WST-A nrPDB Length = 417 Score = 29.7 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 9/68 (13%), Positives = 30/68 (44%), Gaps = 7/68 (10%) Query: 130 HPNLVKLIGYCLEDEHRL-------LVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVAL 182 HP+L++ + + + +++++ G L+ H+ + ++KP + + Sbjct: 269 HPHLIRKMEIAKQSIDLCTNTFGQAIAWKYVENGYLDEHIPKIIEFYKPRRDAMLEALEE 328 Query: 183 DAAKGLAF 190 +G+ + Sbjct: 329 YMPEGVEW 336 >1WP5-A nrPDB Length = 323 Score = 29.7 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 10/50 (20%), Positives = 19/50 (38%), Gaps = 1/50 (2%) Query: 103 AVKKLNQEGFQGHREWLTEINYLGQLS-HPNLVKLIGYCLEDEHRLLVYE 151 AVKK+ F+ + L +L +P+ + + + L E Sbjct: 217 AVKKMKLTEFEKATRAKRGVVILRELKANPHRISGFVVAQDSDTIYLQTE 266 >2P8J-A nrPDB Length = 209 Score = 29.7 bits (65), Expect = 2.6, Method: Composition-based stats. Identities = 18/103 (17%), Positives = 30/103 (29%), Gaps = 2/103 (1%) Query: 14 FHNGKSSDLYGLSLSSRKSSSTVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVI 73 F + S +Y + V A +L + F L + I Sbjct: 85 FKDESMSFVYSYGTIFHMRKNDVKEAIDEIKRVLKPGGLACINF--LTTKDERYNKGEKI 142 Query: 74 GEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHR 116 GEG F + +G + + +K L +E R Sbjct: 143 GEGEFLQLERGEKVIHSYVSLEEADKYFKDMKVLFKEDRVVER 185 >5IVL-B nrPDB Length = 429 Score = 29.3 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 8/32 (25%), Positives = 16/32 (50%), Gaps = 2/32 (6%) Query: 103 AVKKLNQEGFQGHREWLTEINYLGQLSHPNLV 134 AVK++ G ++ +I L HP+++ Sbjct: 95 AVKRVRVLPIYGGQDIERQIRALK--KHPHVI 124 >3ONP-A nrPDB Length = 249 Score = 27.7 bits (60), Expect = 8.1, Method: Composition-based stats. Identities = 15/75 (20%), Positives = 29/75 (38%), Gaps = 6/75 (8%) Query: 289 NLVDWARPYLTSKRKVLLIVDNRLDT------QYLPEEAVRMASVAVQCLSFEPKSRPTM 342 ++D AR S +V + D+ + + PE+A M + P +R + Sbjct: 168 EVIDMARVDFASGLEVEKLGDHFEEKLEAAGFFFPPEKAPGMKLNLRNMWARLPLTRADV 227 Query: 343 DQVVRALQQLQDNLG 357 + L+Q+ L Sbjct: 228 QTLHGMLRQIAWKLK 242 >6OGD-C nrPDB Length = 633 Score = 27.7 bits (60), Expect = 9.3, Method: Composition-based stats. Identities = 24/118 (20%), Positives = 47/118 (39%), Gaps = 10/118 (8%) Query: 84 GWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTEINYL-----GQLSHPNLVKL 136 G DE ++ K G V+ +K+L + G+ EI+ +L N+ +L Sbjct: 353 GGGDEGNISSDKDGENYVLLIKELRSALDSRFGYSN-RKEISIACSGVKAKLKKSNIDQL 411 Query: 137 IGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSD 194 + L D L+ Y+F +++ + P + L A + +LH++ Sbjct: 412 VANGL-DNIYLMSYDFF-GTIWADYIGHHTNLYSPKDPGEQELFDLSAEAAIDYLHNE 467 >4DWS-C nrPDB Length = 546 Score = 27.7 bits (60), Expect = 9.3, Method: Composition-based stats. Identities = 24/118 (20%), Positives = 47/118 (39%), Gaps = 10/118 (8%) Query: 84 GWLDESTLTPTKPGTGLVIAVKKLNQ--EGFQGHREWLTEINYL-----GQLSHPNLVKL 136 G DE ++ K G V+ +K+L + G+ EI+ +L N+ +L Sbjct: 266 GGGDEGNISSDKDGENYVLLIKELRSALDSRFGYSN-RKEISIACSGVKAKLKKSNIDQL 324 Query: 137 IGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSD 194 + L D L+ Y+F +++ + P + L A + +LH++ Sbjct: 325 VANGL-DNIYLMSYDFF-GTIWADYIGHHTNLYSPKDPGEQELFDLSAEAAIDYLHNE 380 >2D4H-A nrPDB Length = 328 Score = 27.7 bits (60), Expect = 9.5, Method: Composition-based stats. Identities = 22/86 (25%), Positives = 33/86 (38%), Gaps = 3/86 (3%) Query: 296 PYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVVRALQQLQDN 355 YLT K+ + +T LP +R +C F+ RP + + L++LQD Sbjct: 211 EYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFD---RPVHRRKLAQLEKLQDE 267 Query: 356 LGKPSQTNPVKDTKKLGFKTGTTKSS 381 P V D F TK+ Sbjct: 268 ELDPEFVQQVADFCSYIFSNSKTKTL 293 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.306 0.132 0.368 Lambda K H 0.267 0.0407 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,542,680 Number of Sequences: 36641 Number of extensions: 553746 Number of successful extensions: 5689 Number of sequences better than 10.0: 515 Number of HSP's better than 10.0 without gapping: 833 Number of HSP's successfully gapped in prelim test: 134 Number of HSP's that attempted gapping in prelim test: 1654 Number of HSP's gapped (non-prelim): 1061 length of query: 395 length of database: 10,336,785 effective HSP length: 99 effective length of query: 296 effective length of database: 6,709,326 effective search space: 1985960496 effective search space used: 1985960496 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.0 bits) S2: 60 (27.7 bits)